Guide to the Human Genome
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Name: OTOF Sequence: fasta or formatted (1997aa) NCBI GI: 34740331
Description:

otoferlin isoform a

Referenced in:

Auditory and Vestibular Functions
Additional Membrane Functions

Other entries for this name:
alt prot [1307aa] otoferlin isoform c
alt prot [1230aa] otoferlin isoform d
alt prot [1230aa] otoferlin isoform b
Composition:

amino acid map
 Amino acid        Percentage    Count  Longest homopolymer
 A alanine             5.5        110           2
 C cysteine            1.4         28           2
 D aspartate           7.4        148           3
 E glutamate           8.2        163           4
 F phenylalanine       4.3         85           2
 G glycine             6.5        129           2
 H histidine           1.9         37           2
 I isoleucine          4.5         89           2
 K lysine              7.1        142           6
 L leucine             9.7        193          11
 M methionine          2.4         47           2
 N asparagine          3.8         75           2
 P proline             6.0        120           2
 Q glutamine           3.3         65           2
 R arginine            6.1        122           3
 S serine              6.2        124           3
 T threonine           4.5         89           2
 V valine              7.1        142           3
 W tryptophan          1.6         32           2
 Y tyrosine            2.9         57           2
Comparative genomics:

Search single species RefSeq proteins at NCBI
   H. sapiens
   M. musculus
   D. rerio
   C. intestinalis
   S. purpuratus
   D. melanogaster
   C. elegans
   A. thaliana
   S. cerevisiae
   E. coli W3110
   A. pernix K1

Search summary

comparative genomics plot

   Figure data

Additional searches of
RefSeq proteins at NCBI

   All
   Eukaryotes
   Bacteria
   Archaea
   Viruses
   Primates
   Mammals
   Vertebrates

Related human proteins:
Protein          Relative score         Description

Self-match            1.000   otoferlin isoform a 
OTOF                  0.632   otoferlin isoform c 
OTOF                  0.614   otoferlin isoform b 
OTOF                  0.606   otoferlin isoform d 
FER1L6                0.441   fer-1-like 6 
DYSF                  0.173   dysferlin isoform 1 
DYSF                  0.173   dysferlin isoform 5 
DYSF                  0.173   dysferlin isoform 6 
DYSF                  0.173   dysferlin isoform 14 
DYSF                  0.173   dysferlin isoform 11 
DYSF                  0.173   dysferlin isoform 10 
DYSF                  0.170   dysferlin isoform 2 
DYSF                  0.170   dysferlin isoform 8 
DYSF                  0.170   dysferlin isoform 3 
DYSF                  0.170   dysferlin isoform 4 
DYSF                  0.170   dysferlin isoform 7 
DYSF                  0.170   dysferlin isoform 13 
DYSF                  0.170   dysferlin isoform 12 
DYSF                  0.170   dysferlin isoform 9 
MYOF                  0.163   myoferlin isoform b 
MYOF                  0.163   myoferlin isoform a 
FER1L5                0.100   fer-1-like 5 isoform 1 
FER1L5                0.098   fer-1-like 5 isoform 2 
RASAL1                0.010   RAS protein activator like 1 
LOC100132214          0.007   PREDICTED: similar to calcium-promoted Ras inactiva...
LOC100132214          0.007   PREDICTED: similar to calcium-promoted Ras inactiva...
LOC100132214          0.007   PREDICTED: similar to calcium-promoted Ras inactiva...
LOC100132214          0.007   PREDICTED: similar to calcium-promoted Ras inactiva...
RASA4                 0.007   RAS p21 protein activator 4 isoform 2 
RASA4                 0.007   RAS p21 protein activator 4 isoform 1 
Human BLASTP results (used to prepare the table)

Gene descriptions are from NCBI RefSeq. Search results were obtained with NCBI BLAST and RefSeq entries. When identical proteins are present, the self-match may not be listed first in BLASTP output. In such cases, the table above has been reordered to place it first.

See About the Figures for the scoring system used in the figure above right. The same scoring system was used in the table of BLASTP results.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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