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Search of human proteins with 11863132
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|11863132 nuclear receptor subfamily 1, group I, member 2
isoform 2 [Homo sapiens]
(473 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|11863132 nuclear receptor subfamily 1, group I, member 2 isof... 965 0.0
gi|34398348 nuclear receptor subfamily 1, group I, member 2 isof... 885 0.0
gi|14702164 nuclear receptor subfamily 1, group I, member 2 isof... 793 0.0
gi|63054845 vitamin D (1,25-dihydroxyvitamin D3) receptor [Homo ... 300 1e-81
gi|4507883 vitamin D (1,25-dihydroxyvitamin D3) receptor [Homo s... 300 1e-81
gi|4826661 constitutive androstane receptor isoform 3 [Homo sapi... 287 1e-77
gi|117938752 constitutive androstane receptor isoform 2 [Homo sa... 286 4e-77
gi|117938756 constitutive androstane receptor isoform 1 [Homo sa... 280 3e-75
gi|117938746 constitutive androstane receptor isoform 7 [Homo sa... 258 1e-68
gi|117938729 constitutive androstane receptor isoform 6 [Homo sa... 253 3e-67
gi|117938750 constitutive androstane receptor isoform 10 [Homo s... 236 3e-62
gi|117938754 constitutive androstane receptor isoform 4 [Homo sa... 234 2e-61
gi|117938734 constitutive androstane receptor isoform 5 [Homo sa... 233 4e-61
gi|117938736 constitutive androstane receptor isoform 9 [Homo sa... 230 2e-60
gi|117938748 constitutive androstane receptor isoform 14 [Homo s... 208 1e-53
gi|117938740 constitutive androstane receptor isoform 8 [Homo sa... 204 1e-52
gi|117938744 constitutive androstane receptor isoform 13 [Homo s... 202 7e-52
gi|117938738 constitutive androstane receptor isoform 12 [Homo s... 200 2e-51
gi|85362735 nuclear receptor subfamily 1, group H, member 2 [Hom... 175 7e-44
gi|194294519 nuclear receptor subfamily 1, group H, member 3 iso... 174 2e-43
gi|194294517 nuclear receptor subfamily 1, group H, member 3 iso... 174 2e-43
gi|4826980 nuclear receptor subfamily 1, group H, member 4 [Homo... 165 7e-41
gi|189491771 thyroid hormone receptor, beta [Homo sapiens] 160 2e-39
gi|189491769 thyroid hormone receptor, beta [Homo sapiens] 160 2e-39
gi|40806162 thyroid hormone receptor, beta [Homo sapiens] 160 2e-39
gi|14916494 retinoic acid receptor, beta isoform 1 [Homo sapiens] 150 3e-36
gi|40806160 thyroid hormone receptor, alpha isoform 1 [Homo sapi... 149 7e-36
gi|67459914 retinoic acid receptor, alpha isoform 2 [Homo sapiens] 146 5e-35
gi|223718064 retinoic acid receptor, alpha isoform 1 [Homo sapiens] 145 6e-35
gi|4506419 retinoic acid receptor, alpha isoform 1 [Homo sapiens] 145 6e-35
>gi|11863132 nuclear receptor subfamily 1, group I, member 2 isoform
2 [Homo sapiens]
Length = 473
Score = 965 bits (2494), Expect = 0.0
Identities = 473/473 (100%), Positives = 473/473 (100%)
Query: 1 MTVTRTHHFKEGSLRAPAIPLHSAAAELASNHPRGPEANLEVRPKESWNHADFVHCEDTE 60
MTVTRTHHFKEGSLRAPAIPLHSAAAELASNHPRGPEANLEVRPKESWNHADFVHCEDTE
Sbjct: 1 MTVTRTHHFKEGSLRAPAIPLHSAAAELASNHPRGPEANLEVRPKESWNHADFVHCEDTE 60
Query: 61 SVPGKPSVNADEEVGGPQICRVCGDKATGYHFNVMTCEGCKGFFRRAMKRNARLRCPFRK 120
SVPGKPSVNADEEVGGPQICRVCGDKATGYHFNVMTCEGCKGFFRRAMKRNARLRCPFRK
Sbjct: 61 SVPGKPSVNADEEVGGPQICRVCGDKATGYHFNVMTCEGCKGFFRRAMKRNARLRCPFRK 120
Query: 121 GACEITRKTRRQCQACRLRKCLESGMKKEMIMSDEAVEERRALIKRKKSERTGTQPLGVQ 180
GACEITRKTRRQCQACRLRKCLESGMKKEMIMSDEAVEERRALIKRKKSERTGTQPLGVQ
Sbjct: 121 GACEITRKTRRQCQACRLRKCLESGMKKEMIMSDEAVEERRALIKRKKSERTGTQPLGVQ 180
Query: 181 GLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGVLSSGCELPESLQAPSREEAAKWSQ 240
GLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGVLSSGCELPESLQAPSREEAAKWSQ
Sbjct: 181 GLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGVLSSGCELPESLQAPSREEAAKWSQ 240
Query: 241 VRKDLCSLKVSLQLRGEDGSVWNYKPPADSGGKEIFSLLPHMADMSTYMFKGIISFAKVI 300
VRKDLCSLKVSLQLRGEDGSVWNYKPPADSGGKEIFSLLPHMADMSTYMFKGIISFAKVI
Sbjct: 241 VRKDLCSLKVSLQLRGEDGSVWNYKPPADSGGKEIFSLLPHMADMSTYMFKGIISFAKVI 300
Query: 301 SYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWECGRLSYCLEDTAGGFQQLLLE 360
SYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWECGRLSYCLEDTAGGFQQLLLE
Sbjct: 301 SYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWECGRLSYCLEDTAGGFQQLLLE 360
Query: 361 PMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHRVVDQLQEQFAITLKSYIECNR 420
PMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHRVVDQLQEQFAITLKSYIECNR
Sbjct: 361 PMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHRVVDQLQEQFAITLKSYIECNR 420
Query: 421 PQPAHRFLFLKIMAMLTELRSINAQHTQRLLRIQDIHPFATPLMQELFGITGS 473
PQPAHRFLFLKIMAMLTELRSINAQHTQRLLRIQDIHPFATPLMQELFGITGS
Sbjct: 421 PQPAHRFLFLKIMAMLTELRSINAQHTQRLLRIQDIHPFATPLMQELFGITGS 473
>gi|34398348 nuclear receptor subfamily 1, group I, member 2 isoform
1 [Homo sapiens]
Length = 434
Score = 885 bits (2287), Expect = 0.0
Identities = 433/434 (99%), Positives = 434/434 (100%)
Query: 40 LEVRPKESWNHADFVHCEDTESVPGKPSVNADEEVGGPQICRVCGDKATGYHFNVMTCEG 99
+EVRPKESWNHADFVHCEDTESVPGKPSVNADEEVGGPQICRVCGDKATGYHFNVMTCEG
Sbjct: 1 MEVRPKESWNHADFVHCEDTESVPGKPSVNADEEVGGPQICRVCGDKATGYHFNVMTCEG 60
Query: 100 CKGFFRRAMKRNARLRCPFRKGACEITRKTRRQCQACRLRKCLESGMKKEMIMSDEAVEE 159
CKGFFRRAMKRNARLRCPFRKGACEITRKTRRQCQACRLRKCLESGMKKEMIMSDEAVEE
Sbjct: 61 CKGFFRRAMKRNARLRCPFRKGACEITRKTRRQCQACRLRKCLESGMKKEMIMSDEAVEE 120
Query: 160 RRALIKRKKSERTGTQPLGVQGLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGVLSS 219
RRALIKRKKSERTGTQPLGVQGLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGVLSS
Sbjct: 121 RRALIKRKKSERTGTQPLGVQGLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGVLSS 180
Query: 220 GCELPESLQAPSREEAAKWSQVRKDLCSLKVSLQLRGEDGSVWNYKPPADSGGKEIFSLL 279
GCELPESLQAPSREEAAKWSQVRKDLCSLKVSLQLRGEDGSVWNYKPPADSGGKEIFSLL
Sbjct: 181 GCELPESLQAPSREEAAKWSQVRKDLCSLKVSLQLRGEDGSVWNYKPPADSGGKEIFSLL 240
Query: 280 PHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWE 339
PHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWE
Sbjct: 241 PHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWE 300
Query: 340 CGRLSYCLEDTAGGFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHR 399
CGRLSYCLEDTAGGFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHR
Sbjct: 301 CGRLSYCLEDTAGGFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHR 360
Query: 400 VVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQHTQRLLRIQDIHPF 459
VVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQHTQRLLRIQDIHPF
Sbjct: 361 VVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQHTQRLLRIQDIHPF 420
Query: 460 ATPLMQELFGITGS 473
ATPLMQELFGITGS
Sbjct: 421 ATPLMQELFGITGS 434
>gi|14702164 nuclear receptor subfamily 1, group I, member 2 isoform
3 [Homo sapiens]
Length = 397
Score = 793 bits (2048), Expect = 0.0
Identities = 396/434 (91%), Positives = 397/434 (91%), Gaps = 37/434 (8%)
Query: 40 LEVRPKESWNHADFVHCEDTESVPGKPSVNADEEVGGPQICRVCGDKATGYHFNVMTCEG 99
+EVRPKESWNHADFVHCEDTESVPGKPSVNADEEVGGPQICRVCGDKATGYHFNVMTCEG
Sbjct: 1 MEVRPKESWNHADFVHCEDTESVPGKPSVNADEEVGGPQICRVCGDKATGYHFNVMTCEG 60
Query: 100 CKGFFRRAMKRNARLRCPFRKGACEITRKTRRQCQACRLRKCLESGMKKEMIMSDEAVEE 159
CKGFFRRAMKRNARLRCPFRKGACEITRKTRRQCQACRLRKCLESGMKKEMIMSDEAVEE
Sbjct: 61 CKGFFRRAMKRNARLRCPFRKGACEITRKTRRQCQACRLRKCLESGMKKEMIMSDEAVEE 120
Query: 160 RRALIKRKKSERTGTQPLGVQGLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGVLSS 219
RRALIKRKKSERTGTQPLGVQGLTEEQRMMIRELMDAQMKTFDTTFSHFKNFR
Sbjct: 121 RRALIKRKKSERTGTQPLGVQGLTEEQRMMIRELMDAQMKTFDTTFSHFKNFR------- 173
Query: 220 GCELPESLQAPSREEAAKWSQVRKDLCSLKVSLQLRGEDGSVWNYKPPADSGGKEIFSLL 279
VSLQLRGEDGSVWNYKPPADSGGKEIFSLL
Sbjct: 174 ------------------------------VSLQLRGEDGSVWNYKPPADSGGKEIFSLL 203
Query: 280 PHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWE 339
PHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWE
Sbjct: 204 PHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWE 263
Query: 340 CGRLSYCLEDTAGGFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHR 399
CGRLSYCLEDTAGGFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHR
Sbjct: 264 CGRLSYCLEDTAGGFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHR 323
Query: 400 VVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQHTQRLLRIQDIHPF 459
VVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQHTQRLLRIQDIHPF
Sbjct: 324 VVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQHTQRLLRIQDIHPF 383
Query: 460 ATPLMQELFGITGS 473
ATPLMQELFGITGS
Sbjct: 384 ATPLMQELFGITGS 397
>gi|63054845 vitamin D (1,25-dihydroxyvitamin D3) receptor [Homo
sapiens]
Length = 427
Score = 300 bits (769), Expect = 1e-81
Identities = 170/405 (41%), Positives = 240/405 (59%), Gaps = 14/405 (3%)
Query: 77 PQICRVCGDKATGYHFNVMTCEGCKGFFRRAMKRNARLRCPFRKGACEITRKTRRQCQAC 136
P+IC VCGD+ATG+HFN MTCEGCKGFFRR+MKR A CPF G C IT+ RR CQAC
Sbjct: 21 PRICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTCPFN-GDCRITKDNRRHCQAC 79
Query: 137 RLRKCLESGMKKEMIMSDEAVEERRALIKRKKSERTGTQPLGVQGLTEEQRMMIRELMDA 196
RL++C++ GM KE I++DE V+ +R +I ++K E L + L+EEQ+ +I L+DA
Sbjct: 80 RLKRCVDIGMMKEFILTDEEVQRKREMILKRKEEEALKDSLRPK-LSEEQQRIIAILLDA 138
Query: 197 QMKTFDTTFSHFKNFRLPGVLSSGC----ELPESLQAPS--REEAAKWSQVRKDLCSLKV 250
KT+D T+S F FR P ++ G P S PS + ++ S +
Sbjct: 139 HHKTYDPTYSDFCQFRPPVRVNDGGGSHPSRPNSRHTPSFSGDSSSSCSDHCITSSDMMD 198
Query: 251 SLQLRGEDGSVWNYKPPADSGGKEIFSLLPHMADMSTYMFKGIISFAKVISYFRDLPIED 310
S D S + P+ + S+LPH+AD+ +Y + +I FAK+I FRDL ED
Sbjct: 199 SSSFSNLDLSEEDSDDPSVTLELSQLSMLPHLADLVSYSIQKVIGFAKMIPGFRDLTSED 258
Query: 311 QISLLKGAAFELCQLRFNTVFNAETGTWECGRLSY---CLEDTAGGFQQLLLEPMLKFHY 367
QI LLK +A E+ LR N F + +W CG Y + T G L+EP++KF
Sbjct: 259 QIVLLKSSAIEVIMLRSNESFTMDDMSWTCGNQDYKYRVSDVTKAGHSLELIEPLIKFQV 318
Query: 368 MLKKLQLHEEEYVLMQAISLFSPDRPGVLQHRVVDQLQEQFAITLKSYIECNRPQPAHRF 427
LKKL LHEEE+VL+ AI + SPDRPGV +++ +Q++ + TL++YI C P P
Sbjct: 319 GLKKLNLHEEEHVLLMAICIVSPDRPGVQDAALIEAIQDRLSNTLQTYIRCRHPPPGSHL 378
Query: 428 LFLKIMAMLTELRSINAQHTQ--RLLRIQ-DIHPFATPLMQELFG 469
L+ K++ L +LRS+N +H++ R L Q + TPL+ E+FG
Sbjct: 379 LYAKMIQKLADLRSLNEEHSKQYRCLSFQPECSMKLTPLVLEVFG 423
>gi|4507883 vitamin D (1,25-dihydroxyvitamin D3) receptor [Homo
sapiens]
Length = 427
Score = 300 bits (769), Expect = 1e-81
Identities = 170/405 (41%), Positives = 240/405 (59%), Gaps = 14/405 (3%)
Query: 77 PQICRVCGDKATGYHFNVMTCEGCKGFFRRAMKRNARLRCPFRKGACEITRKTRRQCQAC 136
P+IC VCGD+ATG+HFN MTCEGCKGFFRR+MKR A CPF G C IT+ RR CQAC
Sbjct: 21 PRICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTCPFN-GDCRITKDNRRHCQAC 79
Query: 137 RLRKCLESGMKKEMIMSDEAVEERRALIKRKKSERTGTQPLGVQGLTEEQRMMIRELMDA 196
RL++C++ GM KE I++DE V+ +R +I ++K E L + L+EEQ+ +I L+DA
Sbjct: 80 RLKRCVDIGMMKEFILTDEEVQRKREMILKRKEEEALKDSLRPK-LSEEQQRIIAILLDA 138
Query: 197 QMKTFDTTFSHFKNFRLPGVLSSGC----ELPESLQAPS--REEAAKWSQVRKDLCSLKV 250
KT+D T+S F FR P ++ G P S PS + ++ S +
Sbjct: 139 HHKTYDPTYSDFCQFRPPVRVNDGGGSHPSRPNSRHTPSFSGDSSSSCSDHCITSSDMMD 198
Query: 251 SLQLRGEDGSVWNYKPPADSGGKEIFSLLPHMADMSTYMFKGIISFAKVISYFRDLPIED 310
S D S + P+ + S+LPH+AD+ +Y + +I FAK+I FRDL ED
Sbjct: 199 SSSFSNLDLSEEDSDDPSVTLELSQLSMLPHLADLVSYSIQKVIGFAKMIPGFRDLTSED 258
Query: 311 QISLLKGAAFELCQLRFNTVFNAETGTWECGRLSY---CLEDTAGGFQQLLLEPMLKFHY 367
QI LLK +A E+ LR N F + +W CG Y + T G L+EP++KF
Sbjct: 259 QIVLLKSSAIEVIMLRSNESFTMDDMSWTCGNQDYKYRVSDVTKAGHSLELIEPLIKFQV 318
Query: 368 MLKKLQLHEEEYVLMQAISLFSPDRPGVLQHRVVDQLQEQFAITLKSYIECNRPQPAHRF 427
LKKL LHEEE+VL+ AI + SPDRPGV +++ +Q++ + TL++YI C P P
Sbjct: 319 GLKKLNLHEEEHVLLMAICIVSPDRPGVQDAALIEAIQDRLSNTLQTYIRCRHPPPGSHL 378
Query: 428 LFLKIMAMLTELRSINAQHTQ--RLLRIQ-DIHPFATPLMQELFG 469
L+ K++ L +LRS+N +H++ R L Q + TPL+ E+FG
Sbjct: 379 LYAKMIQKLADLRSLNEEHSKQYRCLSFQPECSMKLTPLVLEVFG 423
>gi|4826661 constitutive androstane receptor isoform 3 [Homo
sapiens]
Length = 348
Score = 287 bits (735), Expect = 1e-77
Identities = 164/389 (42%), Positives = 226/389 (58%), Gaps = 54/389 (13%)
Query: 80 CRVCGDKATGYHFNVMTCEGCKGFFRRAMKRNARLRCPFRKGACEITRKTRRQCQACRLR 139
C VCGD+ATGYHFN +TCEGCKGFFRR + ++ CPF G+CE+++ RR C ACRL+
Sbjct: 11 CVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGPTCPFA-GSCEVSKTQRRHCPACRLQ 69
Query: 140 KCLESGMKKEMIMSDEAVEERRALIKRKKSERTGTQPLGVQGLTEEQRMMIRELMDAQMK 199
KCL++GM+K+MI+S EA+ RRA ++++++T Q L++EQ +IR L+ A +
Sbjct: 70 KCLDAGMRKDMILSAEALALRRAKQAQRRAQQTPVQ------LSKEQEELIRTLLGAHTR 123
Query: 200 TFDTTFSHFKNFRLPGVLSSGCELPESLQAPSREEAAKWSQVRKDLCSLKVSLQLRGEDG 259
T F F FR P L + P AP
Sbjct: 124 HMGTMFEQFVQFRPPAHLFIHHQ-PLPTLAP----------------------------- 153
Query: 260 SVWNYKPPADSGGKEIFSLLPHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAA 319
+ L+ H AD++T+M +I F K + FR LPIEDQISLLKGAA
Sbjct: 154 ---------------VLPLVTHFADINTFMVLQVIKFTKDLPVFRSLPIEDQISLLKGAA 198
Query: 320 FELCQLRFNTVFNAETGTWECGRLSYCLEDTAG-GFQQLLLEPMLKFHYMLKKLQLHEEE 378
E+C + NT F +T + CG L Y +ED A GFQ LE + FH L+KLQL E E
Sbjct: 199 VEICHIVLNTTFCLQTQNFLCGPLRYTIEDGARVGFQVEFLELLFHFHGTLRKLQLQEPE 258
Query: 379 YVLMQAISLFSPDRPGVLQHRVVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTE 438
YVL+ A++LFSPDRPGV Q +DQLQE+ A+TL+SYI+ + +P RFL+ K++ +L E
Sbjct: 259 YVLLAAMALFSPDRPGVTQRDEIDQLQEEMALTLQSYIKGQQRRPRDRFLYAKLLGLLAE 318
Query: 439 LRSINAQHTQRLLRIQDIHPFATPLMQEL 467
LRSIN + ++ IQ + PL+QE+
Sbjct: 319 LRSINEAYGYQIQHIQGLSAM-MPLLQEI 346
>gi|117938752 constitutive androstane receptor isoform 2 [Homo
sapiens]
Length = 352
Score = 286 bits (731), Expect = 4e-77
Identities = 164/393 (41%), Positives = 226/393 (57%), Gaps = 58/393 (14%)
Query: 80 CRVCGDKATGYHFNVMTCEGCKGFFRRAMKRNARLRCPFRKGACEITRKTRRQCQACRLR 139
C VCGD+ATGYHFN +TCEGCKGFFRR + ++ CPF G+CE+++ RR C ACRL+
Sbjct: 11 CVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGPTCPFA-GSCEVSKTQRRHCPACRLQ 69
Query: 140 KCLESGMKKEMIMSDEAVEERRALIKRKKSERTGTQPLGVQGLTEEQRMMIRELMDAQMK 199
KCL++GM+K+MI+S EA+ RRA ++++++T Q L++EQ +IR L+ A +
Sbjct: 70 KCLDAGMRKDMILSAEALALRRAKQAQRRAQQTPVQ------LSKEQEELIRTLLGAHTR 123
Query: 200 TFDTTFSHFKNFRLPGVLSSGCELPESLQAPSREEAAKWSQVRKDLCSLKVSLQLRGEDG 259
T F F FR P L + P AP
Sbjct: 124 HMGTMFEQFVQFRPPAHLFIHHQ-PLPTLAP----------------------------- 153
Query: 260 SVWNYKPPADSGGKEIFSLLPHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAA 319
+ L+ H AD++T+M +I F K + FR LPIEDQISLLKGAA
Sbjct: 154 ---------------VLPLVTHFADINTFMVLQVIKFTKDLPVFRSLPIEDQISLLKGAA 198
Query: 320 FELCQLRFNTVFNAETGTWECGRLSYCLEDTAG-----GFQQLLLEPMLKFHYMLKKLQL 374
E+C + NT F +T + CG L Y +ED A GFQ LE + FH L+KLQL
Sbjct: 199 VEICHIVLNTTFCLQTQNFLCGPLRYTIEDGARVSPTVGFQVEFLELLFHFHGTLRKLQL 258
Query: 375 HEEEYVLMQAISLFSPDRPGVLQHRVVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMA 434
E EYVL+ A++LFSPDRPGV Q +DQLQE+ A+TL+SYI+ + +P RFL+ K++
Sbjct: 259 QEPEYVLLAAMALFSPDRPGVTQRDEIDQLQEEMALTLQSYIKGQQRRPRDRFLYAKLLG 318
Query: 435 MLTELRSINAQHTQRLLRIQDIHPFATPLMQEL 467
+L ELRSIN + ++ IQ + PL+QE+
Sbjct: 319 LLAELRSINEAYGYQIQHIQGLSAM-MPLLQEI 350
>gi|117938756 constitutive androstane receptor isoform 1 [Homo
sapiens]
Length = 357
Score = 280 bits (715), Expect = 3e-75
Identities = 164/398 (41%), Positives = 226/398 (56%), Gaps = 63/398 (15%)
Query: 80 CRVCGDKATGYHFNVMTCEGCKGFFRRAMKRNARLRCPFRKGACEITRKTRRQCQACRLR 139
C VCGD+ATGYHFN +TCEGCKGFFRR + ++ CPF G+CE+++ RR C ACRL+
Sbjct: 11 CVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGPTCPFA-GSCEVSKTQRRHCPACRLQ 69
Query: 140 KCLESGMKKEMIMSDEAVEERRALIKRKKSERTGTQPLGVQGLTEEQRMMIRELMDAQMK 199
KCL++GM+K+MI+S EA+ RRA ++++++T Q L++EQ +IR L+ A +
Sbjct: 70 KCLDAGMRKDMILSAEALALRRAKQAQRRAQQTPVQ------LSKEQEELIRTLLGAHTR 123
Query: 200 TFDTTFSHFKNFRLPGVLSSGCELPESLQAPSREEAAKWSQVRKDLCSLKVSLQLRGEDG 259
T F F FR P L + P AP
Sbjct: 124 HMGTMFEQFVQFRPPAHLFIHHQ-PLPTLAP----------------------------- 153
Query: 260 SVWNYKPPADSGGKEIFSLLPHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAA 319
+ L+ H AD++T+M +I F K + FR LPIEDQISLLKGAA
Sbjct: 154 ---------------VLPLVTHFADINTFMVLQVIKFTKDLPVFRSLPIEDQISLLKGAA 198
Query: 320 FELCQLRFNTVFNAETGTWECGRLSYCLEDTAG-----GFQQLLLEPMLKFHYMLKKLQL 374
E+C + NT F +T + CG L Y +ED A GFQ LE + FH L+KLQL
Sbjct: 199 VEICHIVLNTTFCLQTQNFLCGPLRYTIEDGARVSPTVGFQVEFLELLFHFHGTLRKLQL 258
Query: 375 HEEEYVLMQAISLFSP-----DRPGVLQHRVVDQLQEQFAITLKSYIECNRPQPAHRFLF 429
E EYVL+ A++LFSP DRPGV Q +DQLQE+ A+TL+SYI+ + +P RFL+
Sbjct: 259 QEPEYVLLAAMALFSPAPYLTDRPGVTQRDEIDQLQEEMALTLQSYIKGQQRRPRDRFLY 318
Query: 430 LKIMAMLTELRSINAQHTQRLLRIQDIHPFATPLMQEL 467
K++ +L ELRSIN + ++ IQ + PL+QE+
Sbjct: 319 AKLLGLLAELRSINEAYGYQIQHIQGLSAM-MPLLQEI 355
>gi|117938746 constitutive androstane receptor isoform 7 [Homo
sapiens]
Length = 339
Score = 258 bits (658), Expect = 1e-68
Identities = 148/352 (42%), Positives = 200/352 (56%), Gaps = 57/352 (16%)
Query: 80 CRVCGDKATGYHFNVMTCEGCKGFFRRAMKRNARLRCPFRKGACEITRKTRRQCQACRLR 139
C VCGD+ATGYHFN +TCEGCKGFFRR + ++ CPF G+CE+++ RR C ACRL+
Sbjct: 11 CVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGPTCPFA-GSCEVSKTQRRHCPACRLQ 69
Query: 140 KCLESGMKKEMIMSDEAVEERRALIKRKKSERTGTQPLGVQGLTEEQRMMIRELMDAQMK 199
KCL++GM+K+MI+S EA+ RRA ++++++T Q L++EQ +IR L+ A +
Sbjct: 70 KCLDAGMRKDMILSAEALALRRAKQAQRRAQQTPVQ------LSKEQEELIRTLLGAHTR 123
Query: 200 TFDTTFSHFKNFRLPGVLSSGCELPESLQAPSREEAAKWSQVRKDLCSLKVSLQLRGEDG 259
T F F FR P L + P AP
Sbjct: 124 HMGTMFEQFVQFRPPAHLFIHHQ-PLPTLAP----------------------------- 153
Query: 260 SVWNYKPPADSGGKEIFSLLPHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAA 319
+ L+ H AD++T+M +I F K + FR LPIEDQISLLKGAA
Sbjct: 154 ---------------VLPLVTHFADINTFMVLQVIKFTKDLPVFRSLPIEDQISLLKGAA 198
Query: 320 FELCQLRFNTVFNAETGTWECGRLSYCLEDTAG-----GFQQLLLEPMLKFHYMLKKLQL 374
E+C + NT F +T + CG L Y +ED A GFQ LE + FH L+KLQL
Sbjct: 199 VEICHIVLNTTFCLQTQNFLCGPLRYTIEDGARVSPTVGFQVEFLELLFHFHGTLRKLQL 258
Query: 375 HEEEYVLMQAISLFSPDRPGVLQHRVVDQLQEQFAITLKSYIECNRPQPAHR 426
E EYVL+ A++LFSPDRPGV Q +DQLQE+ A+TL+SYI+ + +P R
Sbjct: 259 QEPEYVLLAAMALFSPDRPGVTQRDEIDQLQEEMALTLQSYIKGQQRRPRDR 310
>gi|117938729 constitutive androstane receptor isoform 6 [Homo
sapiens]
Length = 340
Score = 253 bits (646), Expect = 3e-67
Identities = 148/353 (41%), Positives = 200/353 (56%), Gaps = 58/353 (16%)
Query: 80 CRVCGDKATGYHFNVMTCEGCKGFFRRAMKRNARLRCPFRKGACEITRKTRRQCQACRLR 139
C VCGD+ATGYHFN +TCEGCKGFFRR + ++ CPF G+CE+++ RR C ACRL+
Sbjct: 11 CVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGPTCPFA-GSCEVSKTQRRHCPACRLQ 69
Query: 140 KCLESGMKKEMIMSDEAVEERRALIKRKKSERTGTQPLGVQGLTEEQRMMIRELMDAQMK 199
KCL++GM+K+MI+S EA+ RRA ++++++T Q L++EQ +IR L+ A +
Sbjct: 70 KCLDAGMRKDMILSAEALALRRAKQAQRRAQQTPVQ------LSKEQEELIRTLLGAHTR 123
Query: 200 TFDTTFSHFKNFRLPGVLSSGCELPESLQAPSREEAAKWSQVRKDLCSLKVSLQLRGEDG 259
T F F FR P L + P AP
Sbjct: 124 HMGTMFEQFVQFRPPAHLFIHHQ-PLPTLAP----------------------------- 153
Query: 260 SVWNYKPPADSGGKEIFSLLPHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAA 319
+ L+ H AD++T+M +I F K + FR LPIEDQISLLKGAA
Sbjct: 154 ---------------VLPLVTHFADINTFMVLQVIKFTKDLPVFRSLPIEDQISLLKGAA 198
Query: 320 FELCQLRFNTVFNAETGTWECGRLSYCLEDTAG-GFQQLLLEPMLKFHYMLKKLQLHEEE 378
E+C + NT F +T + CG L Y +ED A GFQ LE + FH L+KLQL E E
Sbjct: 199 VEICHIVLNTTFCLQTQNFLCGPLRYTIEDGARVGFQVEFLELLFHFHGTLRKLQLQEPE 258
Query: 379 YVLMQAISLFSP-----DRPGVLQHRVVDQLQEQFAITLKSYIECNRPQPAHR 426
YVL+ A++LFSP DRPGV Q +DQLQE+ A+TL+SYI+ + +P R
Sbjct: 259 YVLLAAMALFSPAPYLTDRPGVTQRDEIDQLQEEMALTLQSYIKGQQRRPRDR 311
>gi|117938750 constitutive androstane receptor isoform 10 [Homo
sapiens]
Length = 319
Score = 236 bits (602), Expect = 3e-62
Identities = 143/364 (39%), Positives = 203/364 (55%), Gaps = 54/364 (14%)
Query: 105 RRAMKRNARLRCPFRKGACEITRKTRRQCQACRLRKCLESGMKKEMIMSDEAVEERRALI 164
RR + ++ CPF G+CE+++ RR C ACRL+KCL++GM+K+MI+S EA+ RRA
Sbjct: 7 RRTVSKSIGPTCPFA-GSCEVSKTQRRHCPACRLQKCLDAGMRKDMILSAEALALRRAKQ 65
Query: 165 KRKKSERTGTQPLGVQGLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGVLSSGCELP 224
++++++T Q L++EQ +IR L+ A + T F F FR P L + P
Sbjct: 66 AQRRAQQTPVQ------LSKEQEELIRTLLGAHTRHMGTMFEQFVQFRPPAHLFIHHQ-P 118
Query: 225 ESLQAPSREEAAKWSQVRKDLCSLKVSLQLRGEDGSVWNYKPPADSGGKEIFSLLPHMAD 284
AP + L+ H AD
Sbjct: 119 LPTLAP--------------------------------------------VLPLVTHFAD 134
Query: 285 MSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWECGRLS 344
++T+M +I F K + FR LPIEDQISLLKGAA E+C + NT F +T + CG L
Sbjct: 135 INTFMVLQVIKFTKDLPVFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQTQNFLCGPLR 194
Query: 345 YCLEDTAG-GFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHRVVDQ 403
Y +ED A GFQ LE + FH L+KLQL E EYVL+ A++LFSPDRPGV Q +DQ
Sbjct: 195 YTIEDGARVGFQVEFLELLFHFHGTLRKLQLQEPEYVLLAAMALFSPDRPGVTQRDEIDQ 254
Query: 404 LQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQHTQRLLRIQDIHPFATPL 463
LQE+ A+TL+SYI+ + +P RFL+ K++ +L ELRSIN + ++ IQ + PL
Sbjct: 255 LQEEMALTLQSYIKGQQRRPRDRFLYAKLLGLLAELRSINEAYGYQIQHIQGLSAM-MPL 313
Query: 464 MQEL 467
+QE+
Sbjct: 314 LQEI 317
>gi|117938754 constitutive androstane receptor isoform 4 [Homo
sapiens]
Length = 314
Score = 234 bits (596), Expect = 2e-61
Identities = 142/388 (36%), Positives = 201/388 (51%), Gaps = 86/388 (22%)
Query: 80 CRVCGDKATGYHFNVMTCEGCKGFFRRAMKRNARLRCPFRKGACEITRKTRRQCQACRLR 139
C VCGD+ATGYHFN +TCEGCKGFFRR + ++ CPF G+CE+++ RR C ACRL+
Sbjct: 11 CVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGPTCPF-AGSCEVSKTQRRHCPACRLQ 69
Query: 140 KCLESGMKKEMIMSDEAVEERRALIKRKKSERTGTQPLGVQGLTEEQRMMIRELMDAQMK 199
KCL++GM+K+MI+S EA+ RRA ++++++T Q L++EQ +IR L+ A +
Sbjct: 70 KCLDAGMRKDMILSAEALALRRAKQAQRRAQQTPVQ------LSKEQEELIRTLLGAHTR 123
Query: 200 TFDTTFSHFKNFRLPGVLSSGCELPESLQAPSREEAAKWSQVRKDLCSLKVSLQLRGEDG 259
T F F FR P L + P AP
Sbjct: 124 HMGTMFEQFVQFRPPAHLFIHHQ-PLPTLAP----------------------------- 153
Query: 260 SVWNYKPPADSGGKEIFSLLPHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAA 319
+ L+ H AD++T+M +I F K + FR LPIEDQISLLKGAA
Sbjct: 154 ---------------VLPLVTHFADINTFMVLQVIKFTKDLPVFRSLPIEDQISLLKGAA 198
Query: 320 FELCQLRFNTVFNAETGTWECGRLSYCLEDTAGGFQQLLLEPMLKFHYMLKKLQLHEEEY 379
E+C + NT F +T + CG L Y +ED A
Sbjct: 199 VEICHIVLNTTFCLQTQNFLCGPLRYTIEDGAR--------------------------- 231
Query: 380 VLMQAISLFSPDRPGVLQHRVVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTEL 439
+ + DRPGV Q +DQLQE+ A+TL+SYI+ + +P RFL+ K++ +L EL
Sbjct: 232 ------APYLTDRPGVTQRDEIDQLQEEMALTLQSYIKGQQRRPRDRFLYAKLLGLLAEL 285
Query: 440 RSINAQHTQRLLRIQDIHPFATPLMQEL 467
RSIN + ++ IQ + PL+QE+
Sbjct: 286 RSINEAYGYQIQHIQGLSAM-MPLLQEI 312
>gi|117938734 constitutive androstane receptor isoform 5 [Homo
sapiens]
Length = 309
Score = 233 bits (593), Expect = 4e-61
Identities = 142/388 (36%), Positives = 199/388 (51%), Gaps = 91/388 (23%)
Query: 80 CRVCGDKATGYHFNVMTCEGCKGFFRRAMKRNARLRCPFRKGACEITRKTRRQCQACRLR 139
C VCGD+ATGYHFN +TCEGCKGFFRR + ++ CPF G+CE+++ RR C ACRL+
Sbjct: 11 CVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGPTCPF-AGSCEVSKTQRRHCPACRLQ 69
Query: 140 KCLESGMKKEMIMSDEAVEERRALIKRKKSERTGTQPLGVQGLTEEQRMMIRELMDAQMK 199
KCL++GM+K+MI+S EA+ RRA ++++++T Q L++EQ +IR L+ A +
Sbjct: 70 KCLDAGMRKDMILSAEALALRRAKQAQRRAQQTPVQ------LSKEQEELIRTLLGAHTR 123
Query: 200 TFDTTFSHFKNFRLPGVLSSGCELPESLQAPSREEAAKWSQVRKDLCSLKVSLQLRGEDG 259
T F F FR P L + P AP
Sbjct: 124 HMGTMFEQFVQFRPPAHLFIHHQ-PLPTLAP----------------------------- 153
Query: 260 SVWNYKPPADSGGKEIFSLLPHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAA 319
+ L+ H AD++T+M +I F K + FR LPIEDQISLLKGAA
Sbjct: 154 ---------------VLPLVTHFADINTFMVLQVIKFTKDLPVFRSLPIEDQISLLKGAA 198
Query: 320 FELCQLRFNTVFNAETGTWECGRLSYCLEDTAGGFQQLLLEPMLKFHYMLKKLQLHEEEY 379
E+C + NT F +T + CG L Y +ED A
Sbjct: 199 VEICHIVLNTTFCLQTQNFLCGPLRYTIEDGA---------------------------- 230
Query: 380 VLMQAISLFSPDRPGVLQHRVVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTEL 439
DRPGV Q +DQLQE+ A+TL+SYI+ + +P RFL+ K++ +L EL
Sbjct: 231 ----------RDRPGVTQRDEIDQLQEEMALTLQSYIKGQQRRPRDRFLYAKLLGLLAEL 280
Query: 440 RSINAQHTQRLLRIQDIHPFATPLMQEL 467
RSIN + ++ IQ + PL+QE+
Sbjct: 281 RSINEAYGYQIQHIQGLSAM-MPLLQEI 307
>gi|117938736 constitutive androstane receptor isoform 9 [Homo
sapiens]
Length = 324
Score = 230 bits (586), Expect = 2e-60
Identities = 143/369 (38%), Positives = 203/369 (55%), Gaps = 59/369 (15%)
Query: 105 RRAMKRNARLRCPFRKGACEITRKTRRQCQACRLRKCLESGMKKEMIMSDEAVEERRALI 164
RR + ++ CPF G+CE+++ RR C ACRL+KCL++GM+K+MI+S EA+ RRA
Sbjct: 7 RRTVSKSIGPTCPFA-GSCEVSKTQRRHCPACRLQKCLDAGMRKDMILSAEALALRRAKQ 65
Query: 165 KRKKSERTGTQPLGVQGLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGVLSSGCELP 224
++++++T Q L++EQ +IR L+ A + T F F FR P L + P
Sbjct: 66 AQRRAQQTPVQ------LSKEQEELIRTLLGAHTRHMGTMFEQFVQFRPPAHLFIHHQ-P 118
Query: 225 ESLQAPSREEAAKWSQVRKDLCSLKVSLQLRGEDGSVWNYKPPADSGGKEIFSLLPHMAD 284
AP + L+ H AD
Sbjct: 119 LPTLAP--------------------------------------------VLPLVTHFAD 134
Query: 285 MSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWECGRLS 344
++T+M +I F K + FR LPIEDQISLLKGAA E+C + NT F +T + CG L
Sbjct: 135 INTFMVLQVIKFTKDLPVFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQTQNFLCGPLR 194
Query: 345 YCLEDTAG-GFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSP-----DRPGVLQH 398
Y +ED A GFQ LE + FH L+KLQL E EYVL+ A++LFSP DRPGV Q
Sbjct: 195 YTIEDGARVGFQVEFLELLFHFHGTLRKLQLQEPEYVLLAAMALFSPAPYLTDRPGVTQR 254
Query: 399 RVVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQHTQRLLRIQDIHP 458
+DQLQE+ A+TL+SYI+ + +P RFL+ K++ +L ELRSIN + ++ IQ +
Sbjct: 255 DEIDQLQEEMALTLQSYIKGQQRRPRDRFLYAKLLGLLAELRSINEAYGYQIQHIQGLSA 314
Query: 459 FATPLMQEL 467
PL+QE+
Sbjct: 315 M-MPLLQEI 322
>gi|117938748 constitutive androstane receptor isoform 14 [Homo
sapiens]
Length = 306
Score = 208 bits (529), Expect = 1e-53
Identities = 127/323 (39%), Positives = 177/323 (54%), Gaps = 53/323 (16%)
Query: 105 RRAMKRNARLRCPFRKGACEITRKTRRQCQACRLRKCLESGMKKEMIMSDEAVEERRALI 164
RR + ++ CPF G+CE+++ RR C ACRL+KCL++GM+K+MI+S EA+ RRA
Sbjct: 7 RRTVSKSIGPTCPFA-GSCEVSKTQRRHCPACRLQKCLDAGMRKDMILSAEALALRRAKQ 65
Query: 165 KRKKSERTGTQPLGVQGLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGVLSSGCELP 224
++++++T Q L++EQ +IR L+ A + T F F FR P L + P
Sbjct: 66 AQRRAQQTPVQ------LSKEQEELIRTLLGAHTRHMGTMFEQFVQFRPPAHLFIHHQ-P 118
Query: 225 ESLQAPSREEAAKWSQVRKDLCSLKVSLQLRGEDGSVWNYKPPADSGGKEIFSLLPHMAD 284
AP + L+ H AD
Sbjct: 119 LPTLAP--------------------------------------------VLPLVTHFAD 134
Query: 285 MSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWECGRLS 344
++T+M +I F K + FR LPIEDQISLLKGAA E+C + NT F +T + CG L
Sbjct: 135 INTFMVLQVIKFTKDLPVFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQTQNFLCGPLR 194
Query: 345 YCLEDTAG-GFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHRVVDQ 403
Y +ED A GFQ LE + FH L+KLQL E EYVL+ A++LFSPDRPGV Q +DQ
Sbjct: 195 YTIEDGARVGFQVEFLELLFHFHGTLRKLQLQEPEYVLLAAMALFSPDRPGVTQRDEIDQ 254
Query: 404 LQEQFAITLKSYIECNRPQPAHR 426
LQE+ A+TL+SYI+ + +P R
Sbjct: 255 LQEEMALTLQSYIKGQQRRPRDR 277
>gi|117938740 constitutive androstane receptor isoform 8 [Homo
sapiens]
Length = 296
Score = 204 bits (520), Expect = 1e-52
Identities = 126/347 (36%), Positives = 173/347 (49%), Gaps = 90/347 (25%)
Query: 80 CRVCGDKATGYHFNVMTCEGCKGFFRRAMKRNARLRCPFRKGACEITRKTRRQCQACRLR 139
C VCGD+ATGYHFN +TCEGCKGFFRR + ++ CPF G+CE+++ RR C ACRL+
Sbjct: 11 CVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGPTCPF-AGSCEVSKTQRRHCPACRLQ 69
Query: 140 KCLESGMKKEMIMSDEAVEERRALIKRKKSERTGTQPLGVQGLTEEQRMMIRELMDAQMK 199
KCL++GM+K+MI+S EA+ RRA ++++++T Q L++EQ +IR L+ A +
Sbjct: 70 KCLDAGMRKDMILSAEALALRRAKQAQRRAQQTPVQ------LSKEQEELIRTLLGAHTR 123
Query: 200 TFDTTFSHFKNFRLPGVLSSGCELPESLQAPSREEAAKWSQVRKDLCSLKVSLQLRGEDG 259
T F F FR P L + P AP
Sbjct: 124 HMGTMFEQFVQFRPPAHLFIHHQ-PLPTLAP----------------------------- 153
Query: 260 SVWNYKPPADSGGKEIFSLLPHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAA 319
+ L+ H AD++T+M +I F K + FR LPIEDQISLLKGAA
Sbjct: 154 ---------------VLPLVTHFADINTFMVLQVIKFTKDLPVFRSLPIEDQISLLKGAA 198
Query: 320 FELCQLRFNTVFNAETGTWECGRLSYCLEDTAGGFQQLLLEPMLKFHYMLKKLQLHEEEY 379
E+C + NT F +T + CG L Y +ED A
Sbjct: 199 VEICHIVLNTTFCLQTQNFLCGPLRYTIEDGA---------------------------- 230
Query: 380 VLMQAISLFSPDRPGVLQHRVVDQLQEQFAITLKSYIECNRPQPAHR 426
DRPGV Q +DQLQE+ A+TL+SYI+ + +P R
Sbjct: 231 ----------RDRPGVTQRDEIDQLQEEMALTLQSYIKGQQRRPRDR 267
>gi|117938744 constitutive androstane receptor isoform 13 [Homo
sapiens]
Length = 311
Score = 202 bits (513), Expect = 7e-52
Identities = 127/328 (38%), Positives = 177/328 (53%), Gaps = 58/328 (17%)
Query: 105 RRAMKRNARLRCPFRKGACEITRKTRRQCQACRLRKCLESGMKKEMIMSDEAVEERRALI 164
RR + ++ CPF G+CE+++ RR C ACRL+KCL++GM+K+MI+S EA+ RRA
Sbjct: 7 RRTVSKSIGPTCPFA-GSCEVSKTQRRHCPACRLQKCLDAGMRKDMILSAEALALRRAKQ 65
Query: 165 KRKKSERTGTQPLGVQGLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGVLSSGCELP 224
++++++T Q L++EQ +IR L+ A + T F F FR P L + P
Sbjct: 66 AQRRAQQTPVQ------LSKEQEELIRTLLGAHTRHMGTMFEQFVQFRPPAHLFIHHQ-P 118
Query: 225 ESLQAPSREEAAKWSQVRKDLCSLKVSLQLRGEDGSVWNYKPPADSGGKEIFSLLPHMAD 284
AP + L+ H AD
Sbjct: 119 LPTLAP--------------------------------------------VLPLVTHFAD 134
Query: 285 MSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWECGRLS 344
++T+M +I F K + FR LPIEDQISLLKGAA E+C + NT F +T + CG L
Sbjct: 135 INTFMVLQVIKFTKDLPVFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQTQNFLCGPLR 194
Query: 345 YCLEDTAG-GFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSP-----DRPGVLQH 398
Y +ED A GFQ LE + FH L+KLQL E EYVL+ A++LFSP DRPGV Q
Sbjct: 195 YTIEDGARVGFQVEFLELLFHFHGTLRKLQLQEPEYVLLAAMALFSPAPYLTDRPGVTQR 254
Query: 399 RVVDQLQEQFAITLKSYIECNRPQPAHR 426
+DQLQE+ A+TL+SYI+ + +P R
Sbjct: 255 DEIDQLQEEMALTLQSYIKGQQRRPRDR 282
>gi|117938738 constitutive androstane receptor isoform 12 [Homo
sapiens]
Length = 315
Score = 200 bits (509), Expect = 2e-51
Identities = 127/332 (38%), Positives = 177/332 (53%), Gaps = 62/332 (18%)
Query: 105 RRAMKRNARLRCPFRKGACEITRKTRRQCQACRLRKCLESGMKKEMIMSDEAVEERRALI 164
RR + ++ CPF G+CE+++ RR C ACRL+KCL++GM+K+MI+S EA+ RRA
Sbjct: 7 RRTVSKSIGPTCPFA-GSCEVSKTQRRHCPACRLQKCLDAGMRKDMILSAEALALRRAKQ 65
Query: 165 KRKKSERTGTQPLGVQGLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGVLSSGCELP 224
++++++T Q L++EQ +IR L+ A + T F F FR P L + P
Sbjct: 66 AQRRAQQTPVQ------LSKEQEELIRTLLGAHTRHMGTMFEQFVQFRPPAHLFIHHQ-P 118
Query: 225 ESLQAPSREEAAKWSQVRKDLCSLKVSLQLRGEDGSVWNYKPPADSGGKEIFSLLPHMAD 284
AP + L+ H AD
Sbjct: 119 LPTLAP--------------------------------------------VLPLVTHFAD 134
Query: 285 MSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWECGRLS 344
++T+M +I F K + FR LPIEDQISLLKGAA E+C + NT F +T + CG L
Sbjct: 135 INTFMVLQVIKFTKDLPVFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQTQNFLCGPLR 194
Query: 345 YCLEDTAG-----GFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSP-----DRPG 394
Y +ED A GFQ LE + FH L+KLQL E EYVL+ A++LFSP DRPG
Sbjct: 195 YTIEDGARVSPTVGFQVEFLELLFHFHGTLRKLQLQEPEYVLLAAMALFSPAPYLTDRPG 254
Query: 395 VLQHRVVDQLQEQFAITLKSYIECNRPQPAHR 426
V Q +DQLQE+ A+TL+SYI+ + +P R
Sbjct: 255 VTQRDEIDQLQEEMALTLQSYIKGQQRRPRDR 286
>gi|85362735 nuclear receptor subfamily 1, group H, member 2 [Homo
sapiens]
Length = 461
Score = 175 bits (444), Expect = 7e-44
Identities = 130/455 (28%), Positives = 223/455 (49%), Gaps = 51/455 (11%)
Query: 33 PRGPEANLEVRPKESWN-HADFVHCEDTESVPGKPSVNADEEVGGPQICRVCGDKATGYH 91
P GP+ ++ + S D+V + E K ++ G ++CRVCGDKA+G+H
Sbjct: 39 PGGPDPDVPGTDEASSACSTDWVIPDPEEEPERKRKKGPAPKMLGHELCRVCGDKASGFH 98
Query: 92 FNVMTCEGCKGFFRRAMKRNARLRCPFR-KGACEITRKTRRQCQACRLRKCLESGMKKEM 150
+NV++CEGCKGFFRR++ R R R G C++ RR+CQ CRLRKC E+GM+++
Sbjct: 99 YNVLSCEGCKGFFRRSVVRGGARRYACRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQC 158
Query: 151 IMSDEAVEERRALIKRKKSERTGTQ-PLGVQGLTEEQRMMIRELMDAQMKTFDTTFSHFK 209
++S+E + +++ ++++ ++ +Q P+G QG +
Sbjct: 159 VLSEEQIRKKKIRKQQQQESQSQSQSPVGPQGSSSSASG--------------------- 197
Query: 210 NFRLPGVLSSGCELPESLQAPSREEAAKWSQVRKDLCSLKVSLQLR------GEDGSVWN 263
PG G E Q E + + ++ + V+ QL+ + V
Sbjct: 198 ----PGASPGGSE--AGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNKRSFSDQPKVTP 251
Query: 264 YKPPADSGGKEI-FSLLPHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAFEL 322
+ AD ++ H +++ + I+ FAK + F L EDQI+LLK + E+
Sbjct: 252 WPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQIALLKASTIEI 311
Query: 323 CQLRFNTVFNAETGTWEC----GRLSYCLED-TAGGFQQLLLEPMLKFHYMLKKLQLHEE 377
L +N ET EC +Y +D G Q + P+ +F +++L L +
Sbjct: 312 MLLETARRYNHET---ECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDA 368
Query: 378 EYVLMQAISLFSPDRPGVLQHRVVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLT 437
EY L+ AI++FS DRP V + V+ LQ+ + L SY RPQ R F +++ L
Sbjct: 369 EYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLR--FPRMLMKLV 426
Query: 438 ELRSINAQHTQRL--LRIQDIHPFATPLMQELFGI 470
LR++++ H++++ LR+QD PL+ E++ +
Sbjct: 427 SLRTLSSVHSEQVFALRLQD--KKLPPLLSEIWDV 459
>gi|194294519 nuclear receptor subfamily 1, group H, member 3
isoform c [Homo sapiens]
Length = 402
Score = 174 bits (440), Expect = 2e-43
Identities = 128/428 (29%), Positives = 212/428 (49%), Gaps = 71/428 (16%)
Query: 57 EDTESVPGKPSVNADEEVGGPQICRVCGDKATGYHFNVMTCEGCKGFFRRAMKRNARLRC 116
E TE P K ++ G ++C VCGDKA+G+H+NV++CEGCKGFFRR++ + A C
Sbjct: 30 EPTEIRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAHYIC 89
Query: 117 PFRKGACEITRKTRRQCQACRLRKCLESGMKKEMIMSDEAVEERRALIKRKKSE------ 170
G C + RR+CQ CRLRKC ++GM++E ++S+E + ++ +KR++ E
Sbjct: 90 -HSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKK--LKRQEEEQAHATS 146
Query: 171 ---RTGTQPLGVQGLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGVLSSGCELPESL 227
R + P + L+ EQ MI +L+ AQ + +FS
Sbjct: 147 LPPRASSPPQILPQLSPEQLGMIEKLVAAQQQCNRRSFS--------------------- 185
Query: 228 QAPSREEAAKWSQVRKDLCSLKVSLQLRGEDGSVWNYKPPADSGGKEIFSLLPHMADMST 287
R W P + ++ F+ +A +S
Sbjct: 186 ---DRLRVTPWPMAP----------------------DPHSREARQQRFAHFTELAIVSV 220
Query: 288 YMFKGIISFAKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFN--AETGTWECGRLSY 345
+ I+ FAK + F L EDQI+LLK +A E+ L + +N +E+ T+ SY
Sbjct: 221 ---QEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLLETSRRYNPGSESITF-LKDFSY 276
Query: 346 CLEDTA-GGFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHRVVDQL 404
ED A G Q + P+ +F + +LQL++ E+ L+ AIS+FS DRP V V++L
Sbjct: 277 NREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLIAISIFSADRPNVQDQLQVERL 336
Query: 405 QEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQHTQRL--LRIQDIHPFATP 462
Q + L +Y+ + P R +F +++ L LR++++ H++++ LR+QD P
Sbjct: 337 QHTYVEALHAYVSIHHPH--DRLMFPRMLMKLVSLRTLSSVHSEQVFALRLQD--KKLPP 392
Query: 463 LMQELFGI 470
L+ E++ +
Sbjct: 393 LLSEIWDV 400
>gi|194294517 nuclear receptor subfamily 1, group H, member 3
isoform a [Homo sapiens]
Length = 447
Score = 174 bits (440), Expect = 2e-43
Identities = 128/428 (29%), Positives = 212/428 (49%), Gaps = 71/428 (16%)
Query: 57 EDTESVPGKPSVNADEEVGGPQICRVCGDKATGYHFNVMTCEGCKGFFRRAMKRNARLRC 116
E TE P K ++ G ++C VCGDKA+G+H+NV++CEGCKGFFRR++ + A C
Sbjct: 75 EPTEIRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAHYIC 134
Query: 117 PFRKGACEITRKTRRQCQACRLRKCLESGMKKEMIMSDEAVEERRALIKRKKSE------ 170
G C + RR+CQ CRLRKC ++GM++E ++S+E + ++ +KR++ E
Sbjct: 135 -HSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKK--LKRQEEEQAHATS 191
Query: 171 ---RTGTQPLGVQGLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGVLSSGCELPESL 227
R + P + L+ EQ MI +L+ AQ + +FS
Sbjct: 192 LPPRASSPPQILPQLSPEQLGMIEKLVAAQQQCNRRSFS--------------------- 230
Query: 228 QAPSREEAAKWSQVRKDLCSLKVSLQLRGEDGSVWNYKPPADSGGKEIFSLLPHMADMST 287
R W P + ++ F+ +A +S
Sbjct: 231 ---DRLRVTPWPMAP----------------------DPHSREARQQRFAHFTELAIVSV 265
Query: 288 YMFKGIISFAKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFN--AETGTWECGRLSY 345
+ I+ FAK + F L EDQI+LLK +A E+ L + +N +E+ T+ SY
Sbjct: 266 ---QEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLLETSRRYNPGSESITF-LKDFSY 321
Query: 346 CLEDTA-GGFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHRVVDQL 404
ED A G Q + P+ +F + +LQL++ E+ L+ AIS+FS DRP V V++L
Sbjct: 322 NREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLIAISIFSADRPNVQDQLQVERL 381
Query: 405 QEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQHTQRL--LRIQDIHPFATP 462
Q + L +Y+ + P R +F +++ L LR++++ H++++ LR+QD P
Sbjct: 382 QHTYVEALHAYVSIHHPH--DRLMFPRMLMKLVSLRTLSSVHSEQVFALRLQD--KKLPP 437
Query: 463 LMQELFGI 470
L+ E++ +
Sbjct: 438 LLSEIWDV 445
>gi|4826980 nuclear receptor subfamily 1, group H, member 4 [Homo
sapiens]
Length = 472
Score = 165 bits (418), Expect = 7e-41
Identities = 124/417 (29%), Positives = 202/417 (48%), Gaps = 61/417 (14%)
Query: 62 VPGKPSVNADE-EVGGPQICRVCGDKATGYHFNVMTCEGCKGFFRRAMKRNARLRCPFRK 120
V KP + A + G ++C VCGD+A+GYH+N +TCEGCKGFFRR++ +NA +C
Sbjct: 108 VTKKPRMGASAGRIKGDELCVVCGDRASGYHYNALTCEGCKGFFRRSITKNAVYKCK-NG 166
Query: 121 GACEITRKTRRQCQACRLRKCLESGMKKEMIMSDEAVEERRALIKRKKSERTGTQPLGVQ 180
G C + RR+CQ CRLRKC E GM E ++++ + +R RK ++ Q +
Sbjct: 167 GNCVMDMYMRRKCQECRLRKCKEMGMLAECLLTEIQCKSKRL---RKNVKQHADQTVNED 223
Query: 181 GLTEEQRMMIRELMDAQMKTFDT----TFSHFKNFRLPGVLSSGCELPESLQAPSREEAA 236
+ R + + KT T T HF ++ S
Sbjct: 224 SEGRDLRQVTSTTKSCREKTELTPDQQTLLHF-------IMDS----------------- 259
Query: 237 KWSQVRKDLCSLKVSLQLRGEDGSVWNYKPPADSGGKEIFSLLPHMADMSTYMFKGIISF 296
K +++ ++ E+ S +E F +L +M+T + ++ F
Sbjct: 260 ----YNKQRMPQEITNKILKEEFS-----------AEENFLIL---TEMATNHVQVLVEF 301
Query: 297 AKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWECGRLSYCLEDTAGGFQQ 356
K + F+ L EDQI+LLKG+A E LR +FN + + L + ++ G
Sbjct: 302 TKKLPGFQTLDHEDQIALLKGSAVEAMFLRSAEIFNKKLPSGHSDLLEERIRNS--GISD 359
Query: 357 LLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHRVVDQLQEQFAITLKSYI 416
+ PM F+ + +L++ +EEY L+ AI + SPDR + V++LQE L+
Sbjct: 360 EYITPMFSFYKSIGELKMTQEEYALLTAIVILSPDRQYIKDREAVEKLQEPLLDVLQKLC 419
Query: 417 ECNRPQ-PAHRFLFLKIMAMLTELRSINAQHTQRLL--RIQDIHPFATPLMQELFGI 470
+ ++P+ P H F ++ LTELR+ N H + L+ R+ D H F TPL+ E++ +
Sbjct: 420 KIHQPENPQH---FACLLGRLTELRTFNHHHAEMLMSWRVND-HKF-TPLLCEIWDV 471
>gi|189491771 thyroid hormone receptor, beta [Homo sapiens]
Length = 461
Score = 160 bits (406), Expect = 2e-39
Identities = 117/401 (29%), Positives = 182/401 (45%), Gaps = 56/401 (13%)
Query: 78 QICRVCGDKATGYHFNVMTCEGCKGFFRRAMKRNAR--LRCPFRKGACEITRKTRRQCQA 135
++C VCGDKATGYH+ +TCEGCKGFFRR +++N C + +G C I + TR QCQ
Sbjct: 105 ELCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCKY-EGKCVIDKVTRNQCQE 163
Query: 136 CRLRKCLESGMKKEMIMSDEAVEERRALIKRKKSERTGTQPLGVQG----LTEEQRMMIR 191
CR +KC+ GM ++++ D +R LI+ + +R + G T+E+ +I+
Sbjct: 164 CRFKKCIYVGMATDLVLDDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWELIK 223
Query: 192 ELMDAQMKTFDTTFSHFKNFRLPGVLSSGCELPESL-QAPSREEAAKWSQVRKDLCSLKV 250
+ +A + T + SH+K R LPE + QAP
Sbjct: 224 TVTEAHVAT-NAQGSHWKQKRK--------FLPEDIGQAPIVN----------------- 257
Query: 251 SLQLRGEDGSVWNYKPPADSGGKEIFSLLPHMADMSTYMFKGIISFAKVISYFRDLPIED 310
A GGK H + T ++ FAK + F +LP ED
Sbjct: 258 -----------------APEGGKVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCED 300
Query: 311 QISLLKGAAFELCQLRFNTVFNAETGTWEC-GRLSYCLEDTAGGFQQLLLEPMLKFHYML 369
QI LLKG E+ LR ++ E+ T G ++ G ++ + + L
Sbjct: 301 QIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSL 360
Query: 370 KKLQLHEEEYVLMQAISLFSPDRPGVLQHRVVDQLQEQFAITLKSYIECNRPQPAHRFLF 429
L + E L+QA+ L S DRPG+ +++ Q+ F + + YI + H +
Sbjct: 361 SSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTH--FW 418
Query: 430 LKIMAMLTELRSINAQHTQRLLRIQDIHP--FATPLMQELF 468
K++ +T+LR I A H R L ++ P PL E+F
Sbjct: 419 PKLLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVF 459
>gi|189491769 thyroid hormone receptor, beta [Homo sapiens]
Length = 461
Score = 160 bits (406), Expect = 2e-39
Identities = 117/401 (29%), Positives = 182/401 (45%), Gaps = 56/401 (13%)
Query: 78 QICRVCGDKATGYHFNVMTCEGCKGFFRRAMKRNAR--LRCPFRKGACEITRKTRRQCQA 135
++C VCGDKATGYH+ +TCEGCKGFFRR +++N C + +G C I + TR QCQ
Sbjct: 105 ELCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCKY-EGKCVIDKVTRNQCQE 163
Query: 136 CRLRKCLESGMKKEMIMSDEAVEERRALIKRKKSERTGTQPLGVQG----LTEEQRMMIR 191
CR +KC+ GM ++++ D +R LI+ + +R + G T+E+ +I+
Sbjct: 164 CRFKKCIYVGMATDLVLDDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWELIK 223
Query: 192 ELMDAQMKTFDTTFSHFKNFRLPGVLSSGCELPESL-QAPSREEAAKWSQVRKDLCSLKV 250
+ +A + T + SH+K R LPE + QAP
Sbjct: 224 TVTEAHVAT-NAQGSHWKQKRK--------FLPEDIGQAPIVN----------------- 257
Query: 251 SLQLRGEDGSVWNYKPPADSGGKEIFSLLPHMADMSTYMFKGIISFAKVISYFRDLPIED 310
A GGK H + T ++ FAK + F +LP ED
Sbjct: 258 -----------------APEGGKVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCED 300
Query: 311 QISLLKGAAFELCQLRFNTVFNAETGTWEC-GRLSYCLEDTAGGFQQLLLEPMLKFHYML 369
QI LLKG E+ LR ++ E+ T G ++ G ++ + + L
Sbjct: 301 QIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSL 360
Query: 370 KKLQLHEEEYVLMQAISLFSPDRPGVLQHRVVDQLQEQFAITLKSYIECNRPQPAHRFLF 429
L + E L+QA+ L S DRPG+ +++ Q+ F + + YI + H +
Sbjct: 361 SSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTH--FW 418
Query: 430 LKIMAMLTELRSINAQHTQRLLRIQDIHP--FATPLMQELF 468
K++ +T+LR I A H R L ++ P PL E+F
Sbjct: 419 PKLLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVF 459
>gi|40806162 thyroid hormone receptor, beta [Homo sapiens]
Length = 461
Score = 160 bits (406), Expect = 2e-39
Identities = 117/401 (29%), Positives = 182/401 (45%), Gaps = 56/401 (13%)
Query: 78 QICRVCGDKATGYHFNVMTCEGCKGFFRRAMKRNAR--LRCPFRKGACEITRKTRRQCQA 135
++C VCGDKATGYH+ +TCEGCKGFFRR +++N C + +G C I + TR QCQ
Sbjct: 105 ELCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCKY-EGKCVIDKVTRNQCQE 163
Query: 136 CRLRKCLESGMKKEMIMSDEAVEERRALIKRKKSERTGTQPLGVQG----LTEEQRMMIR 191
CR +KC+ GM ++++ D +R LI+ + +R + G T+E+ +I+
Sbjct: 164 CRFKKCIYVGMATDLVLDDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWELIK 223
Query: 192 ELMDAQMKTFDTTFSHFKNFRLPGVLSSGCELPESL-QAPSREEAAKWSQVRKDLCSLKV 250
+ +A + T + SH+K R LPE + QAP
Sbjct: 224 TVTEAHVAT-NAQGSHWKQKRK--------FLPEDIGQAPIVN----------------- 257
Query: 251 SLQLRGEDGSVWNYKPPADSGGKEIFSLLPHMADMSTYMFKGIISFAKVISYFRDLPIED 310
A GGK H + T ++ FAK + F +LP ED
Sbjct: 258 -----------------APEGGKVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCED 300
Query: 311 QISLLKGAAFELCQLRFNTVFNAETGTWEC-GRLSYCLEDTAGGFQQLLLEPMLKFHYML 369
QI LLKG E+ LR ++ E+ T G ++ G ++ + + L
Sbjct: 301 QIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSL 360
Query: 370 KKLQLHEEEYVLMQAISLFSPDRPGVLQHRVVDQLQEQFAITLKSYIECNRPQPAHRFLF 429
L + E L+QA+ L S DRPG+ +++ Q+ F + + YI + H +
Sbjct: 361 SSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTH--FW 418
Query: 430 LKIMAMLTELRSINAQHTQRLLRIQDIHP--FATPLMQELF 468
K++ +T+LR I A H R L ++ P PL E+F
Sbjct: 419 PKLLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVF 459
>gi|14916494 retinoic acid receptor, beta isoform 1 [Homo sapiens]
Length = 448
Score = 150 bits (378), Expect = 3e-36
Identities = 128/429 (29%), Positives = 191/429 (44%), Gaps = 76/429 (17%)
Query: 48 WNHADFVHCEDTES------VPGKPSVNADEEVGGPQICRVCGDKATGYHFNVMTCEGCK 101
W H +T+S VP PS V P C VC DK++GYH+ V CEGCK
Sbjct: 45 WQHRHTAQSIETQSTSSEELVPSPPSPLPPPRVYKP--CFVCQDKSSGYHYGVSACEGCK 102
Query: 102 GFFRRAMKRNARLRCPFRKGACEITRKTRRQCQACRLRKCLESGMKKEMIMSDEAVEERR 161
GFFRR++++N C R C I + TR +CQ CRL+KC E GM KE + +D
Sbjct: 103 GFFRRSIQKNMIYTC-HRDKNCVINKVTRNRCQYCRLQKCFEVGMSKESVRNDR------ 155
Query: 162 ALIKRKKSERTGTQPLGVQGLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGVLSSGC 221
+KK E + + +T E + ++ A +TF S C
Sbjct: 156 ---NKKKKETSKQECTESYEMTAELDDLTEKIRKAHQETF----------------PSLC 196
Query: 222 ELPESLQAPSREEAAKWSQVRKDLCSLKVSLQLRGEDGSVWNYKPPADSGGKEIFSLLPH 281
+L + S + +VR DL +W+
Sbjct: 197 QLGKYTTNSSADH-----RVRLDL--------------GLWD-----------------K 220
Query: 282 MADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAE--TGTWE 339
++++T I+ FAK + F L I DQI+LLK A ++ LR T + E T T+
Sbjct: 221 FSELATKCIIKIVEFAKRLPGFTGLTIADQITLLKAACLDILILRICTRYTPEQDTMTFS 280
Query: 340 CGRLSYCLEDTAGGFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHR 399
G + GF L + + F L L++ + E L+ AI L DR + +
Sbjct: 281 DGLTLNRTQMHNAGFGP-LTDLVFTFANQLLPLEMDDTETGLLSAICLICGDRQDLEEPT 339
Query: 400 VVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQHTQRLLRIQ-DIHP 458
VD+LQE LK YI RP H +F KI+ +T+LRSI+A+ +R++ ++ +I
Sbjct: 340 KVDKLQEPLLEALKIYIRKRRPSKPH--MFPKILMKITDLRSISAKGAERVITLKMEIPG 397
Query: 459 FATPLMQEL 467
PL+QE+
Sbjct: 398 SMPPLIQEM 406
>gi|40806160 thyroid hormone receptor, alpha isoform 1 [Homo
sapiens]
Length = 410
Score = 149 bits (375), Expect = 7e-36
Identities = 115/394 (29%), Positives = 175/394 (44%), Gaps = 46/394 (11%)
Query: 80 CRVCGDKATGYHFNVMTCEGCKGFFRRAMKRNAR--LRCPFRKGACEITRKTRRQCQACR 137
C VCGDKATGYH+ +TCEGCKGFFRR +++N C + C I + TR QCQ CR
Sbjct: 53 CVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKY-DSCCVIDKITRNQCQLCR 111
Query: 138 LRKCLESGMKKEMIMSDEAVEERRALIKRKKSERTGTQPLGVQGLTEEQRMMIRELMDAQ 197
+KC+ GM ++++ D +R LI++ + R + MIR L
Sbjct: 112 FKKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERR-------------RKEEMIRSLQQRP 158
Query: 198 MKTFDTTFSHFKNFRLPGVLSSGCELPESLQAPSREEAAKWSQVRKDLCSLKVSLQLRGE 257
T + ++ E S A + + W Q RK L G+
Sbjct: 159 EPTPEEW----------DLIHIATEAHRSTNA----QGSHWKQRRKFL------PDDIGQ 198
Query: 258 DGSVWNYKPPADSGGKEIFSLLPHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKG 317
V P D E FS + T ++ FAK + F +LP EDQI LLKG
Sbjct: 199 SPIV--SMPDGDKVDLEAFS---EFTKIITPAITRVVDFAKKLPMFSELPCEDQIILLKG 253
Query: 318 AAFELCQLRFNTVFNAETGTWE-CGRLSYCLEDTAGGFQQLLLEPMLKFHYMLKKLQLHE 376
E+ LR ++ E+ T G ++ E G ++ + + + L L +
Sbjct: 254 CCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGGLGVVSDAIFELGKSLSAFNLDD 313
Query: 377 EEYVLMQAISLFSPDRPGVLQHRVVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAML 436
E L+QA+ L S DR G+L +++ QE + + + Y+ + H + K++ +
Sbjct: 314 TEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHYVNHRKHNIPH--FWPKLLMKV 371
Query: 437 TELRSINAQHTQRLLRIQDIHP--FATPLMQELF 468
T+LR I A H R L ++ P PL E+F
Sbjct: 372 TDLRMIGACHASRFLHMKVECPTELFPPLFLEVF 405
>gi|67459914 retinoic acid receptor, alpha isoform 2 [Homo sapiens]
Length = 457
Score = 146 bits (368), Expect = 5e-35
Identities = 129/429 (30%), Positives = 192/429 (44%), Gaps = 78/429 (18%)
Query: 48 WNHADFVHCEDTES------VPGKPSVNADEEVGGPQICRVCGDKATGYHFNVMTCEGCK 101
WN ++ H +T+S VP PS + P C VC DK++GYH+ V CEGCK
Sbjct: 49 WNGSN--HSIETQSSSSEEIVPSPPSPPPLPRIYKP--CFVCQDKSSGYHYGVSACEGCK 104
Query: 102 GFFRRAMKRNARLRCPFRKGACEITRKTRRQCQACRLRKCLESGMKKEMIMSDEAVEERR 161
GFFRR++++N C R C I + TR +CQ CRL+KC E GM KE + +D
Sbjct: 105 GFFRRSIQKNMVYTC-HRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDR------ 157
Query: 162 ALIKRKKSERTGTQPLGVQGLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGVLSSGC 221
+KK E + LT E +I ++ A +TF C
Sbjct: 158 ---NKKKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPAL----------------C 198
Query: 222 ELPESLQAPSREEAAKWSQVRKDLCSLKVSLQLRGEDGSVWNYKPPADSGGKEIFSLLPH 281
+L + S E+ +VSL D +W+
Sbjct: 199 QLGKYTTNNSSEQ--------------RVSL-----DIDLWD-----------------K 222
Query: 282 MADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAE--TGTWE 339
+++ST + FAK + F L I DQI+LLK A ++ LR T + E T T+
Sbjct: 223 FSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFS 282
Query: 340 CGRLSYCLEDTAGGFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHR 399
G + GF L + + F L L++ + E L+ AI L DR + Q
Sbjct: 283 DGLTLNRTQMHNAGFGP-LTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPD 341
Query: 400 VVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQHTQRLLRIQ-DIHP 458
VD LQE LK Y+ RP H +F K++ +T+LRSI+A+ +R++ ++ +I
Sbjct: 342 RVDMLQEPLLEALKVYVRKRRPSRPH--MFPKMLMKITDLRSISAKGAERVITLKMEIPG 399
Query: 459 FATPLMQEL 467
PL+QE+
Sbjct: 400 SMPPLIQEM 408
>gi|223718064 retinoic acid receptor, alpha isoform 1 [Homo sapiens]
Length = 462
Score = 145 bits (367), Expect = 6e-35
Identities = 125/411 (30%), Positives = 184/411 (44%), Gaps = 70/411 (17%)
Query: 60 ESVPGKPSVNADEEVGGPQICRVCGDKATGYHFNVMTCEGCKGFFRRAMKRNARLRCPFR 119
E VP PS + P C VC DK++GYH+ V CEGCKGFFRR++++N C R
Sbjct: 70 EIVPSPPSPPPLPRIYKP--CFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYTC-HR 126
Query: 120 KGACEITRKTRRQCQACRLRKCLESGMKKEMIMSDEAVEERRALIKRKKSERTGTQPLGV 179
C I + TR +CQ CRL+KC E GM KE + +D +KK E +
Sbjct: 127 DKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDR---------NKKKKEVPKPECSES 177
Query: 180 QGLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGVLSSGCELPESLQAPSREEAAKWS 239
LT E +I ++ A +TF C+L + S E+
Sbjct: 178 YTLTPEVGELIEKVRKAHQETFPAL----------------CQLGKYTTNNSSEQ----- 216
Query: 240 QVRKDLCSLKVSLQLRGEDGSVWNYKPPADSGGKEIFSLLPHMADMSTYMFKGIISFAKV 299
+VSL D +W+ +++ST + FAK
Sbjct: 217 ---------RVSL-----DIDLWD-----------------KFSELSTKCIIKTVEFAKQ 245
Query: 300 ISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAE--TGTWECGRLSYCLEDTAGGFQQL 357
+ F L I DQI+LLK A ++ LR T + E T T+ G + GF
Sbjct: 246 LPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGP- 304
Query: 358 LLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHRVVDQLQEQFAITLKSYIE 417
L + + F L L++ + E L+ AI L DR + Q VD LQE LK Y+
Sbjct: 305 LTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVYVR 364
Query: 418 CNRPQPAHRFLFLKIMAMLTELRSINAQHTQRLLRIQ-DIHPFATPLMQEL 467
RP H +F K++ +T+LRSI+A+ +R++ ++ +I PL+QE+
Sbjct: 365 KRRPSRPH--MFPKMLMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEM 413
>gi|4506419 retinoic acid receptor, alpha isoform 1 [Homo sapiens]
Length = 462
Score = 145 bits (367), Expect = 6e-35
Identities = 125/411 (30%), Positives = 184/411 (44%), Gaps = 70/411 (17%)
Query: 60 ESVPGKPSVNADEEVGGPQICRVCGDKATGYHFNVMTCEGCKGFFRRAMKRNARLRCPFR 119
E VP PS + P C VC DK++GYH+ V CEGCKGFFRR++++N C R
Sbjct: 70 EIVPSPPSPPPLPRIYKP--CFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYTC-HR 126
Query: 120 KGACEITRKTRRQCQACRLRKCLESGMKKEMIMSDEAVEERRALIKRKKSERTGTQPLGV 179
C I + TR +CQ CRL+KC E GM KE + +D +KK E +
Sbjct: 127 DKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDR---------NKKKKEVPKPECSES 177
Query: 180 QGLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGVLSSGCELPESLQAPSREEAAKWS 239
LT E +I ++ A +TF C+L + S E+
Sbjct: 178 YTLTPEVGELIEKVRKAHQETFPAL----------------CQLGKYTTNNSSEQ----- 216
Query: 240 QVRKDLCSLKVSLQLRGEDGSVWNYKPPADSGGKEIFSLLPHMADMSTYMFKGIISFAKV 299
+VSL D +W+ +++ST + FAK
Sbjct: 217 ---------RVSL-----DIDLWD-----------------KFSELSTKCIIKTVEFAKQ 245
Query: 300 ISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAE--TGTWECGRLSYCLEDTAGGFQQL 357
+ F L I DQI+LLK A ++ LR T + E T T+ G + GF
Sbjct: 246 LPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGP- 304
Query: 358 LLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHRVVDQLQEQFAITLKSYIE 417
L + + F L L++ + E L+ AI L DR + Q VD LQE LK Y+
Sbjct: 305 LTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVYVR 364
Query: 418 CNRPQPAHRFLFLKIMAMLTELRSINAQHTQRLLRIQ-DIHPFATPLMQEL 467
RP H +F K++ +T+LRSI+A+ +R++ ++ +I PL+QE+
Sbjct: 365 KRRPSRPH--MFPKMLMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEM 413
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.135 0.411
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,911,795
Number of Sequences: 37866
Number of extensions: 861332
Number of successful extensions: 2661
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 118
Number of HSP's successfully gapped in prelim test: 19
Number of HSP's that attempted gapping in prelim test: 2210
Number of HSP's gapped (non-prelim): 258
length of query: 473
length of database: 18,247,518
effective HSP length: 106
effective length of query: 367
effective length of database: 14,233,722
effective search space: 5223775974
effective search space used: 5223775974
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.