Guide to the Human Genome
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Search of human proteins with 239753084

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|239753084 PREDICTED: Beclin-1-like protein 1 [Homo sapiens]
         (431 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|239753084 PREDICTED: Beclin-1-like protein 1 [Homo sapiens]        860   0.0  
gi|88952907 PREDICTED: Beclin-1-like protein 1 [Homo sapiens]         860   0.0  
gi|88943925 PREDICTED: Beclin-1-like protein 1 [Homo sapiens]         860   0.0  
gi|4502395 beclin 1 [Homo sapiens]                                    463   e-130
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa...    41   0.002
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s...    41   0.002
gi|222418793 EF-hand calcium binding domain 4B isoform b [Homo s...    40   0.004
gi|222418791 EF-hand calcium binding domain 4B isoform a [Homo s...    40   0.004
gi|87298937 centrosomal protein 110kDa [Homo sapiens]                  40   0.005
gi|110611218 ribosome binding protein 1 [Homo sapiens]                 39   0.007
gi|110611220 ribosome binding protein 1 [Homo sapiens]                 39   0.007
gi|205277396 dynactin 1 isoform 4 [Homo sapiens]                       39   0.009
gi|205277392 dynactin 1 isoform 3 [Homo sapiens]                       39   0.009
gi|13259508 dynactin 1 isoform 2 [Homo sapiens]                        39   0.009
gi|13259510 dynactin 1 isoform 1 [Homo sapiens]                        39   0.009
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H...    39   0.009
gi|29171755 PTPRF interacting protein alpha 2 [Homo sapiens]           39   0.009
gi|58530840 desmoplakin isoform I [Homo sapiens]                       39   0.012
gi|41322923 plectin 1 isoform 11 [Homo sapiens]                        39   0.012
gi|41322914 plectin 1 isoform 10 [Homo sapiens]                        39   0.012
gi|41322919 plectin 1 isoform 8 [Homo sapiens]                         39   0.012
gi|41322910 plectin 1 isoform 7 [Homo sapiens]                         39   0.012
gi|41322916 plectin 1 isoform 6 [Homo sapiens]                         39   0.012
gi|41322908 plectin 1 isoform 3 [Homo sapiens]                         39   0.012
gi|41322912 plectin 1 isoform 2 [Homo sapiens]                         39   0.012
gi|47607492 plectin 1 isoform 1 [Homo sapiens]                         39   0.012
gi|190194355 p90 autoantigen [Homo sapiens]                            38   0.016
gi|194353964 coiled-coil domain containing 157 [Homo sapiens]          38   0.016
gi|56550043 sarcolemma associated protein [Homo sapiens]               38   0.016
gi|122937382 Fas (TNFRSF6) binding factor 1 [Homo sapiens]             38   0.020

>gi|239753084 PREDICTED: Beclin-1-like protein 1 [Homo sapiens]
          Length = 431

 Score =  860 bits (2222), Expect = 0.0
 Identities = 431/431 (100%), Positives = 431/431 (100%)

Query: 1   MSSIRFLCQRCHQALKLSGSSESRSLPAAPAPTSGQAEPGDTREPGVTTREVTDAEEQQD 60
           MSSIRFLCQRCHQALKLSGSSESRSLPAAPAPTSGQAEPGDTREPGVTTREVTDAEEQQD
Sbjct: 1   MSSIRFLCQRCHQALKLSGSSESRSLPAAPAPTSGQAEPGDTREPGVTTREVTDAEEQQD 60

Query: 61  GASSRSPPGDGSVSKGHANIFTLLGELGAMHMLSSIQKXAGDIFDIVSGQAVVDHPLCEE 120
           GASSRSPPGDGSVSKGHANIFTLLGELGAMHMLSSIQK AGDIFDIVSGQAVVDHPLCEE
Sbjct: 61  GASSRSPPGDGSVSKGHANIFTLLGELGAMHMLSSIQKXAGDIFDIVSGQAVVDHPLCEE 120

Query: 121 CTDSLLEQLDIQLALTEADSQNYQRCLETGELATSEDEAAALRAELRDLELEEARLVQEL 180
           CTDSLLEQLDIQLALTEADSQNYQRCLETGELATSEDEAAALRAELRDLELEEARLVQEL
Sbjct: 121 CTDSLLEQLDIQLALTEADSQNYQRCLETGELATSEDEAAALRAELRDLELEEARLVQEL 180

Query: 181 EDVDRNNARAAADLQAAQAEAAELDQQERQHYRDYSALKRQQLELLDQLGNVENQLQYAR 240
           EDVDRNNARAAADLQAAQAEAAELDQQERQHYRDYSALKRQQLELLDQLGNVENQLQYAR
Sbjct: 181 EDVDRNNARAAADLQAAQAEAAELDQQERQHYRDYSALKRQQLELLDQLGNVENQLQYAR 240

Query: 241 VQRDRLKEINCFTATFEIWVEGPLGVINNFRLGRLPTVRVGWNEINTAWGQAALLLLTLA 300
           VQRDRLKEINCFTATFEIWVEGPLGVINNFRLGRLPTVRVGWNEINTAWGQAALLLLTLA
Sbjct: 241 VQRDRLKEINCFTATFEIWVEGPLGVINNFRLGRLPTVRVGWNEINTAWGQAALLLLTLA 300

Query: 301 NTIGLQFQRYRLIPCGNHSYLKSLTDDRTELPLFCYGGQDVFLNNKYDRAMVAFLDCMQQ 360
           NTIGLQFQRYRLIPCGNHSYLKSLTDDRTELPLFCYGGQDVFLNNKYDRAMVAFLDCMQQ
Sbjct: 301 NTIGLQFQRYRLIPCGNHSYLKSLTDDRTELPLFCYGGQDVFLNNKYDRAMVAFLDCMQQ 360

Query: 361 FKEEAEKGELGLSLPYGIQVETGLMEDVGGRGECYSIRTHLNTQELWTKALKFMLINFKW 420
           FKEEAEKGELGLSLPYGIQVETGLMEDVGGRGECYSIRTHLNTQELWTKALKFMLINFKW
Sbjct: 361 FKEEAEKGELGLSLPYGIQVETGLMEDVGGRGECYSIRTHLNTQELWTKALKFMLINFKW 420

Query: 421 SLIWVASRYQK 431
           SLIWVASRYQK
Sbjct: 421 SLIWVASRYQK 431


>gi|88952907 PREDICTED: Beclin-1-like protein 1 [Homo sapiens]
          Length = 431

 Score =  860 bits (2222), Expect = 0.0
 Identities = 430/431 (99%), Positives = 430/431 (99%)

Query: 1   MSSIRFLCQRCHQALKLSGSSESRSLPAAPAPTSGQAEPGDTREPGVTTREVTDAEEQQD 60
           MSSIRFLCQRCHQALKLSGSSESRSLPAAPAPTSGQAEPGDTREPGVTTREVTDAEEQQD
Sbjct: 1   MSSIRFLCQRCHQALKLSGSSESRSLPAAPAPTSGQAEPGDTREPGVTTREVTDAEEQQD 60

Query: 61  GASSRSPPGDGSVSKGHANIFTLLGELGAMHMLSSIQKXAGDIFDIVSGQAVVDHPLCEE 120
           GASSRSPPGDGSVSKGHANIFTLLGELGAMHMLSSIQK AGDIFDIVSGQAVVDHPLCEE
Sbjct: 61  GASSRSPPGDGSVSKGHANIFTLLGELGAMHMLSSIQKAAGDIFDIVSGQAVVDHPLCEE 120

Query: 121 CTDSLLEQLDIQLALTEADSQNYQRCLETGELATSEDEAAALRAELRDLELEEARLVQEL 180
           CTDSLLEQLDIQLALTEADSQNYQRCLETGELATSEDEAAALRAELRDLELEEARLVQEL
Sbjct: 121 CTDSLLEQLDIQLALTEADSQNYQRCLETGELATSEDEAAALRAELRDLELEEARLVQEL 180

Query: 181 EDVDRNNARAAADLQAAQAEAAELDQQERQHYRDYSALKRQQLELLDQLGNVENQLQYAR 240
           EDVDRNNARAAADLQAAQAEAAELDQQERQHYRDYSALKRQQLELLDQLGNVENQLQYAR
Sbjct: 181 EDVDRNNARAAADLQAAQAEAAELDQQERQHYRDYSALKRQQLELLDQLGNVENQLQYAR 240

Query: 241 VQRDRLKEINCFTATFEIWVEGPLGVINNFRLGRLPTVRVGWNEINTAWGQAALLLLTLA 300
           VQRDRLKEINCFTATFEIWVEGPLGVINNFRLGRLPTVRVGWNEINTAWGQAALLLLTLA
Sbjct: 241 VQRDRLKEINCFTATFEIWVEGPLGVINNFRLGRLPTVRVGWNEINTAWGQAALLLLTLA 300

Query: 301 NTIGLQFQRYRLIPCGNHSYLKSLTDDRTELPLFCYGGQDVFLNNKYDRAMVAFLDCMQQ 360
           NTIGLQFQRYRLIPCGNHSYLKSLTDDRTELPLFCYGGQDVFLNNKYDRAMVAFLDCMQQ
Sbjct: 301 NTIGLQFQRYRLIPCGNHSYLKSLTDDRTELPLFCYGGQDVFLNNKYDRAMVAFLDCMQQ 360

Query: 361 FKEEAEKGELGLSLPYGIQVETGLMEDVGGRGECYSIRTHLNTQELWTKALKFMLINFKW 420
           FKEEAEKGELGLSLPYGIQVETGLMEDVGGRGECYSIRTHLNTQELWTKALKFMLINFKW
Sbjct: 361 FKEEAEKGELGLSLPYGIQVETGLMEDVGGRGECYSIRTHLNTQELWTKALKFMLINFKW 420

Query: 421 SLIWVASRYQK 431
           SLIWVASRYQK
Sbjct: 421 SLIWVASRYQK 431


>gi|88943925 PREDICTED: Beclin-1-like protein 1 [Homo sapiens]
          Length = 431

 Score =  860 bits (2222), Expect = 0.0
 Identities = 430/431 (99%), Positives = 430/431 (99%)

Query: 1   MSSIRFLCQRCHQALKLSGSSESRSLPAAPAPTSGQAEPGDTREPGVTTREVTDAEEQQD 60
           MSSIRFLCQRCHQALKLSGSSESRSLPAAPAPTSGQAEPGDTREPGVTTREVTDAEEQQD
Sbjct: 1   MSSIRFLCQRCHQALKLSGSSESRSLPAAPAPTSGQAEPGDTREPGVTTREVTDAEEQQD 60

Query: 61  GASSRSPPGDGSVSKGHANIFTLLGELGAMHMLSSIQKXAGDIFDIVSGQAVVDHPLCEE 120
           GASSRSPPGDGSVSKGHANIFTLLGELGAMHMLSSIQK AGDIFDIVSGQAVVDHPLCEE
Sbjct: 61  GASSRSPPGDGSVSKGHANIFTLLGELGAMHMLSSIQKAAGDIFDIVSGQAVVDHPLCEE 120

Query: 121 CTDSLLEQLDIQLALTEADSQNYQRCLETGELATSEDEAAALRAELRDLELEEARLVQEL 180
           CTDSLLEQLDIQLALTEADSQNYQRCLETGELATSEDEAAALRAELRDLELEEARLVQEL
Sbjct: 121 CTDSLLEQLDIQLALTEADSQNYQRCLETGELATSEDEAAALRAELRDLELEEARLVQEL 180

Query: 181 EDVDRNNARAAADLQAAQAEAAELDQQERQHYRDYSALKRQQLELLDQLGNVENQLQYAR 240
           EDVDRNNARAAADLQAAQAEAAELDQQERQHYRDYSALKRQQLELLDQLGNVENQLQYAR
Sbjct: 181 EDVDRNNARAAADLQAAQAEAAELDQQERQHYRDYSALKRQQLELLDQLGNVENQLQYAR 240

Query: 241 VQRDRLKEINCFTATFEIWVEGPLGVINNFRLGRLPTVRVGWNEINTAWGQAALLLLTLA 300
           VQRDRLKEINCFTATFEIWVEGPLGVINNFRLGRLPTVRVGWNEINTAWGQAALLLLTLA
Sbjct: 241 VQRDRLKEINCFTATFEIWVEGPLGVINNFRLGRLPTVRVGWNEINTAWGQAALLLLTLA 300

Query: 301 NTIGLQFQRYRLIPCGNHSYLKSLTDDRTELPLFCYGGQDVFLNNKYDRAMVAFLDCMQQ 360
           NTIGLQFQRYRLIPCGNHSYLKSLTDDRTELPLFCYGGQDVFLNNKYDRAMVAFLDCMQQ
Sbjct: 301 NTIGLQFQRYRLIPCGNHSYLKSLTDDRTELPLFCYGGQDVFLNNKYDRAMVAFLDCMQQ 360

Query: 361 FKEEAEKGELGLSLPYGIQVETGLMEDVGGRGECYSIRTHLNTQELWTKALKFMLINFKW 420
           FKEEAEKGELGLSLPYGIQVETGLMEDVGGRGECYSIRTHLNTQELWTKALKFMLINFKW
Sbjct: 361 FKEEAEKGELGLSLPYGIQVETGLMEDVGGRGECYSIRTHLNTQELWTKALKFMLINFKW 420

Query: 421 SLIWVASRYQK 431
           SLIWVASRYQK
Sbjct: 421 SLIWVASRYQK 431


>gi|4502395 beclin 1 [Homo sapiens]
          Length = 450

 Score =  463 bits (1192), Expect = e-130
 Identities = 244/435 (56%), Positives = 300/435 (68%), Gaps = 10/435 (2%)

Query: 4   IRFLCQRCHQALKLSGSSESRSLPA-----APAPTSGQAEPGDTREPGVTTREVTDAEE- 57
           + F+CQRC Q LKL  S +           AP  T+ QA+PG+T+E    + E    E  
Sbjct: 14  VSFVCQRCSQPLKLDTSFKILDRVTIQELTAPLLTTAQAKPGETQEEETNSGEEPFIETP 73

Query: 58  QQDGASSRSPPGDGSVSKGHANIFTLLGEL---GAMHMLSSIQKXAGDIFDIVSGQAVVD 114
           +QDG S R  P    +S   AN FTL+GE    G M  LS   K  GD+FDI+SGQ  VD
Sbjct: 74  RQDGVSRRFIPPARMMSTESANSFTLIGEASDGGTMENLSRRLKVTGDLFDIMSGQTDVD 133

Query: 115 HPLCEECTDSLLEQLDIQLALTEADSQNYQRCLETGELATSEDEAAALRAELRDLELEEA 174
           HPLCEECTD+LL+QLD QL +TE + QNY+RCLE  E   +ED++  L+ EL++L LEE 
Sbjct: 134 HPLCEECTDTLLDQLDTQLNVTENECQNYKRCLEILE-QMNEDDSEQLQMELKELALEEE 192

Query: 175 RLVQELEDVDRNNARAAADLQAAQAEAAELDQQERQHYRDYSALKRQQLELLDQLGNVEN 234
           RL+QELEDV++N    A +L+  QAEA  LDQ+E Q+ R+YS  KRQQLEL D+L +VEN
Sbjct: 193 RLIQELEDVEKNRKIVAENLEKVQAEAERLDQEEAQYQREYSEFKRQQLELDDELKSVEN 252

Query: 235 QLQYARVQRDRLKEINCFTATFEIWVEGPLGVINNFRLGRLPTVRVGWNEINTAWGQAAL 294
           Q++YA+ Q D+LK+ N F ATF IW  G  G INNFRLGRLP+V V WNEIN AWGQ  L
Sbjct: 253 QMRYAQTQLDKLKKTNVFNATFHIWHSGQFGTINNFRLGRLPSVPVEWNEINAAWGQTVL 312

Query: 295 LLLTLANTIGLQFQRYRLIPCGNHSYLKSLTDDRTELPLFCYGGQDVFLNNKYDRAMVAF 354
           LL  LAN +GL+FQRYRL+P GNHSYL+SLTD   ELPL+C GG   F +NK+D AMVAF
Sbjct: 313 LLHALANKMGLKFQRYRLVPYGNHSYLESLTDKSKELPLYCSGGLRFFWDNKFDHAMVAF 372

Query: 355 LDCMQQFKEEAEKGELGLSLPYGIQVETGLMEDVGGRGECYSIRTHLNTQELWTKALKFM 414
           LDC+QQFKEE EKGE    LPY + VE G +ED GG G  YSI+T  N++E WTKALKFM
Sbjct: 373 LDCVQQFKEEVEKGETRFCLPYRMDVEKGKIEDTGGSGGSYSIKTQFNSEEQWTKALKFM 432

Query: 415 LINFKWSLIWVASRY 429
           L N KW L WV+S++
Sbjct: 433 LTNLKWGLAWVSSQF 447


>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
           sapiens]
          Length = 1843

 Score = 41.2 bits (95), Expect = 0.002
 Identities = 31/124 (25%), Positives = 60/124 (48%), Gaps = 9/124 (7%)

Query: 127 EQLDIQLALTEADSQNYQRCLETGELATSEDEAAALRAELRDLELEEARLVQELEDVDRN 186
           E+L++     + ++Q  Q+ LE      S  +   L +EL+DLE+E   L + LE++  +
Sbjct: 752 ERLEVSYQGLDIENQRLQKTLEN-----SNKKIQQLESELQDLEMENQTLQKNLEELKIS 806

Query: 187 NARAAADLQAAQAEAAELDQQERQHYRDYSALKRQQLELLDQLGNVENQLQYARVQRDRL 246
           + R    L+  + E   L+Q+  Q  +D   L+++   L  Q    +  L+   V+   L
Sbjct: 807 SKR----LEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNL 862

Query: 247 KEIN 250
           ++ N
Sbjct: 863 EKEN 866



 Score = 38.5 bits (88), Expect = 0.012
 Identities = 28/102 (27%), Positives = 50/102 (49%), Gaps = 4/102 (3%)

Query: 141  QNYQRCLETGELATSEDEAAALRAELRDLELEEARLVQELEDVDRNNARAAADLQAAQAE 200
            Q+ +R +++    + ED       E ++   E  ++   L +V+RNNA   A+ QA + +
Sbjct: 1011 QDEERMVQSSPPISGEDNK--WERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQ 1068

Query: 201  AAELDQQERQHYRDYSALKRQQLELLDQLGNVENQLQYARVQ 242
              +L+ Q         AL+RQ + L +Q  N   Q Q A++Q
Sbjct: 1069 LKQLETQNNNLQAQILALQRQTVSLQEQ--NTTLQTQNAKLQ 1108



 Score = 35.4 bits (80), Expect = 0.10
 Identities = 37/139 (26%), Positives = 66/139 (47%), Gaps = 21/139 (15%)

Query: 127 EQLDIQLALTEADSQNYQRCLETGELATSEDEAAALRAELRDLELEEARLVQELEDV--D 184
           + L ++LA  +A  +  ++     EL    ++    + EL  +E+E  RL QE  ++  D
Sbjct: 247 QHLSVELADAKAKIRRLRQ-----ELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSD 301

Query: 185 RNNARAAAD-LQAAQAEAAELDQQERQ--HYRD-------YSA----LKRQQLELLDQLG 230
             +AR   D L A + +A  +D+ E +   Y++       Y A    LK     LL+   
Sbjct: 302 ARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKT 361

Query: 231 NVENQLQYARVQRDRLKEI 249
            +E+QL+  R + D+L E+
Sbjct: 362 MLEDQLEGTRARSDKLHEL 380



 Score = 29.6 bits (65), Expect = 5.5
 Identities = 23/98 (23%), Positives = 44/98 (44%), Gaps = 2/98 (2%)

Query: 152  LATSEDEAAALRAELRDLELEEARLVQELEDVDRN--NARAAADLQAAQAEAAELDQQER 209
            L   E++ AAL A L +      +L QEL+ V +N    +   D +     +  +  ++ 
Sbjct: 969  LEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDN 1028

Query: 210  QHYRDYSALKRQQLELLDQLGNVENQLQYARVQRDRLK 247
            +  R+     R+ L++ D+L  VE      + ++  LK
Sbjct: 1029 KWERESQETTRELLKVKDRLIEVERNNATLQAEKQALK 1066



 Score = 29.3 bits (64), Expect = 7.2
 Identities = 22/111 (19%), Positives = 56/111 (50%), Gaps = 3/111 (2%)

Query: 136  TEADSQNYQRCLETGELATSEDEAAALRAELRDLELEEARLVQELEDVDRNNARAAADLQ 195
            T   +QN Q  ++   L   E+E  ++  E  DL+     L+++ E ++  + R A++ +
Sbjct: 1119 TSLMNQNAQLLIQQSSL---ENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYE 1175

Query: 196  AAQAEAAELDQQERQHYRDYSALKRQQLELLDQLGNVENQLQYARVQRDRL 246
            +  ++   L    +    ++  L+ +  +LL Q G +E+  +  +V+++++
Sbjct: 1176 SLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKM 1226


>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
           sapiens]
          Length = 1870

 Score = 41.2 bits (95), Expect = 0.002
 Identities = 31/124 (25%), Positives = 60/124 (48%), Gaps = 9/124 (7%)

Query: 127 EQLDIQLALTEADSQNYQRCLETGELATSEDEAAALRAELRDLELEEARLVQELEDVDRN 186
           E+L++     + ++Q  Q+ LE      S  +   L +EL+DLE+E   L + LE++  +
Sbjct: 752 ERLEVSYQGLDIENQRLQKTLEN-----SNKKIQQLESELQDLEMENQTLQKNLEELKIS 806

Query: 187 NARAAADLQAAQAEAAELDQQERQHYRDYSALKRQQLELLDQLGNVENQLQYARVQRDRL 246
           + R    L+  + E   L+Q+  Q  +D   L+++   L  Q    +  L+   V+   L
Sbjct: 807 SKR----LEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNL 862

Query: 247 KEIN 250
           ++ N
Sbjct: 863 EKEN 866



 Score = 38.5 bits (88), Expect = 0.012
 Identities = 28/102 (27%), Positives = 50/102 (49%), Gaps = 4/102 (3%)

Query: 141  QNYQRCLETGELATSEDEAAALRAELRDLELEEARLVQELEDVDRNNARAAADLQAAQAE 200
            Q+ +R +++    + ED       E ++   E  ++   L +V+RNNA   A+ QA + +
Sbjct: 1010 QDEERMVQSSPPISGEDNK--WERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQ 1067

Query: 201  AAELDQQERQHYRDYSALKRQQLELLDQLGNVENQLQYARVQ 242
              +L+ Q         AL+RQ + L +Q  N   Q Q A++Q
Sbjct: 1068 LKQLETQNNNLQAQILALQRQTVSLQEQ--NTTLQTQNAKLQ 1107



 Score = 35.4 bits (80), Expect = 0.10
 Identities = 37/139 (26%), Positives = 66/139 (47%), Gaps = 21/139 (15%)

Query: 127 EQLDIQLALTEADSQNYQRCLETGELATSEDEAAALRAELRDLELEEARLVQELEDV--D 184
           + L ++LA  +A  +  ++     EL    ++    + EL  +E+E  RL QE  ++  D
Sbjct: 247 QHLSVELADAKAKIRRLRQ-----ELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSD 301

Query: 185 RNNARAAAD-LQAAQAEAAELDQQERQ--HYRD-------YSA----LKRQQLELLDQLG 230
             +AR   D L A + +A  +D+ E +   Y++       Y A    LK     LL+   
Sbjct: 302 ARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKT 361

Query: 231 NVENQLQYARVQRDRLKEI 249
            +E+QL+  R + D+L E+
Sbjct: 362 MLEDQLEGTRARSDKLHEL 380



 Score = 30.0 bits (66), Expect = 4.2
 Identities = 30/131 (22%), Positives = 55/131 (41%), Gaps = 13/131 (9%)

Query: 119  EECTDSLLEQLDIQLALTEADSQNYQRCLETGELATSEDEAAALRAELRDLELEEARLVQ 178
            E+ TD   + L+ +L  T   S           L   E++ AAL A L +      +L Q
Sbjct: 946  EQSTDDRYKLLESKLESTLKKS-----------LEIKEEKIAALEARLEESTNYNQQLRQ 994

Query: 179  ELEDVDRN--NARAAADLQAAQAEAAELDQQERQHYRDYSALKRQQLELLDQLGNVENQL 236
            EL+ V +N    +   D +     +  +  ++ +  R+     R+ L++ D+L  VE   
Sbjct: 995  ELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNN 1054

Query: 237  QYARVQRDRLK 247
               + ++  LK
Sbjct: 1055 ATLQAEKQALK 1065



 Score = 29.3 bits (64), Expect = 7.2
 Identities = 22/111 (19%), Positives = 56/111 (50%), Gaps = 3/111 (2%)

Query: 136  TEADSQNYQRCLETGELATSEDEAAALRAELRDLELEEARLVQELEDVDRNNARAAADLQ 195
            T   +QN Q  ++   L   E+E  ++  E  DL+     L+++ E ++  + R A++ +
Sbjct: 1118 TSLMNQNAQLLIQQSSL---ENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYE 1174

Query: 196  AAQAEAAELDQQERQHYRDYSALKRQQLELLDQLGNVENQLQYARVQRDRL 246
            +  ++   L    +    ++  L+ +  +LL Q G +E+  +  +V+++++
Sbjct: 1175 SLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKM 1225


>gi|222418793 EF-hand calcium binding domain 4B isoform b [Homo
           sapiens]
          Length = 462

 Score = 40.0 bits (92), Expect = 0.004
 Identities = 31/102 (30%), Positives = 51/102 (50%), Gaps = 2/102 (1%)

Query: 144 QRCLETGELATSEDEAAALRAELRDLELEEARLVQELEDVDRNNARAAADLQAAQAEAAE 203
           Q+ LE G+      +    +AE   L+L    L +ELE        A   L++ Q EA +
Sbjct: 284 QKRLE-GQCTALHHDKHETKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEACK 342

Query: 204 LDQQ-ERQHYRDYSALKRQQLELLDQLGNVENQLQYARVQRD 244
           L Q+ E + YR   +L+R++  LL QL  +  + ++ R +RD
Sbjct: 343 LHQEKEMEVYRVTESLQREKAGLLKQLDFLRERNKHLRDERD 384


>gi|222418791 EF-hand calcium binding domain 4B isoform a [Homo
           sapiens]
          Length = 731

 Score = 40.0 bits (92), Expect = 0.004
 Identities = 31/102 (30%), Positives = 51/102 (50%), Gaps = 2/102 (1%)

Query: 144 QRCLETGELATSEDEAAALRAELRDLELEEARLVQELEDVDRNNARAAADLQAAQAEAAE 203
           Q+ LE G+      +    +AE   L+L    L +ELE        A   L++ Q EA +
Sbjct: 284 QKRLE-GQCTALHHDKHETKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEACK 342

Query: 204 LDQQ-ERQHYRDYSALKRQQLELLDQLGNVENQLQYARVQRD 244
           L Q+ E + YR   +L+R++  LL QL  +  + ++ R +RD
Sbjct: 343 LHQEKEMEVYRVTESLQREKAGLLKQLDFLRERNKHLRDERD 384


>gi|87298937 centrosomal protein 110kDa [Homo sapiens]
          Length = 2325

 Score = 39.7 bits (91), Expect = 0.005
 Identities = 28/117 (23%), Positives = 60/117 (51%), Gaps = 2/117 (1%)

Query: 133  LALTEADSQNYQR-CLETG-ELATSEDEAAALRAELRDLELEEARLVQELEDVDRNNARA 190
            L  TE+D++  +R   ET   L  ++ +  +L+A+ +DLE  + +  + L+++++  A  
Sbjct: 1470 LLQTESDAEELERRAQETAVNLVKADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAK 1529

Query: 191  AADLQAAQAEAAELDQQERQHYRDYSALKRQQLELLDQLGNVENQLQYARVQRDRLK 247
             +D Q    +  +L ++ ++  +D    +R +   L  L   E  LQ  R + ++LK
Sbjct: 1530 DSDFQCLSKKKEKLTEELQKLQKDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLK 1586



 Score = 38.1 bits (87), Expect = 0.016
 Identities = 23/64 (35%), Positives = 32/64 (50%)

Query: 147  LETGELATSEDEAAALRAELRDLELEEARLVQELEDVDRNNARAAADLQAAQAEAAELDQ 206
            L T EL  ++D+  +L   +  +  E A  +QE E   R  A+AA DL  A+AE   L  
Sbjct: 989  LATAELTIAKDQLKSLHGTVMKINQERAEELQEAERFSRKAAQAARDLTRAEAEIELLQN 1048

Query: 207  QERQ 210
              RQ
Sbjct: 1049 LLRQ 1052



 Score = 36.6 bits (83), Expect = 0.045
 Identities = 29/133 (21%), Positives = 60/133 (45%), Gaps = 15/133 (11%)

Query: 130  DIQLALTEADSQNYQRCLETGELATSEDEAAALRAEL---------------RDLELEEA 174
            D+Q AL   +++  ++C    E+ +  +E +  + EL               +++E EE 
Sbjct: 1623 DLQEALRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEE 1682

Query: 175  RLVQELEDVDRNNARAAADLQAAQAEAAELDQQERQHYRDYSALKRQQLELLDQLGNVEN 234
             L   L  + ++       L   Q E  EL   + QH +  S L++ Q+ +L++   +EN
Sbjct: 1683 NLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQRVSELEKTQVAVLEEKLELEN 1742

Query: 235  QLQYARVQRDRLK 247
              Q ++ Q+  ++
Sbjct: 1743 LQQISQQQKGEIE 1755



 Score = 36.6 bits (83), Expect = 0.045
 Identities = 30/112 (26%), Positives = 49/112 (43%), Gaps = 11/112 (9%)

Query: 118  CEECTDSLLEQLDIQLALTEADSQNYQRCLETGELATSEDEAAALRAELRDLELEEARLV 177
            C EC     E L  +  + E      +R L     A +E+ +   ++ L  LEL   +L 
Sbjct: 1781 CVECLSKEKEDLQEKCDIWEKKLAQTKRVL-----AAAEENSKMEQSNLEKLELNVRKLQ 1835

Query: 178  QELEDVDRNNARAAADLQAAQ------AEAAELDQQERQHYRDYSALKRQQL 223
            QEL+ ++R+      D+ A Q       EA    Q+E  + +D+  L +Q L
Sbjct: 1836 QELDQLNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDL 1887



 Score = 36.2 bits (82), Expect = 0.059
 Identities = 32/135 (23%), Positives = 65/135 (48%), Gaps = 5/135 (3%)

Query: 119 EECTDSLLEQLDIQLALTEADSQNYQRCLETGE--LATSEDEAAALRAELRDLELEEARL 176
           EE  D   +  + Q+A  EA  ++ +  +   +  L T + +A   + E R L  E+  L
Sbjct: 590 EEIKDLEEQLTEGQIAANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETL 649

Query: 177 VQELEDVDRNNAR---AAADLQAAQAEAAELDQQERQHYRDYSALKRQQLELLDQLGNVE 233
           +Q L +V++   +    A D +  + E AEL+   ++ +   ++L++ Q +L      +E
Sbjct: 650 LQRLTEVEQERDQLEIVAMDAENMRKELAELESALQEQHEVNASLQQTQGDLSAYEAELE 709

Query: 234 NQLQYARVQRDRLKE 248
            +L     + ++LKE
Sbjct: 710 ARLNLRDAEANQLKE 724



 Score = 35.8 bits (81), Expect = 0.077
 Identities = 49/198 (24%), Positives = 84/198 (42%), Gaps = 39/198 (19%)

Query: 49  TREVTDAEEQQDGASSRSPPGDGSVSKGHANIFTLLGELGAMHMLSSIQKXAGDIFDIVS 108
           T E+ D EEQ           +G ++   A    L G      ++S +Q+  G I     
Sbjct: 589 TEEIKDLEEQLT---------EGQIAANEALKKDLEG------VISGLQEYLGTI----K 629

Query: 109 GQAVVDHPLCEECTDSLLEQLDIQLALTEADSQNYQRCLETGELATSEDEAAALRAELRD 168
           GQA      C +  D   E+  +   LTE +        E  +L     +A  +R EL +
Sbjct: 630 GQATQAQNECRKLRD---EKETLLQRLTEVEQ-------ERDQLEIVAMDAENMRKELAE 679

Query: 169 LELEEARLVQELEDVDRNNARAAADLQAAQAEAAELDQQERQHYRDYSALK-RQQLELLD 227
           LE      +QE  +V+ +  +   DL A +AE      + R + RD  A + +++LE + 
Sbjct: 680 LE----SALQEQHEVNASLQQTQGDLSAYEAEL-----EARLNLRDAEANQLKEELEKVT 730

Query: 228 QLGNVENQLQYARVQRDR 245
           +L  +E     A ++++R
Sbjct: 731 RLTQLEQSALQAELEKER 748


>gi|110611218 ribosome binding protein 1 [Homo sapiens]
          Length = 977

 Score = 39.3 bits (90), Expect = 0.007
 Identities = 39/164 (23%), Positives = 72/164 (43%), Gaps = 30/164 (18%)

Query: 110 QAVVDHPLCEECTDSLLEQLDIQLALTE------------ADSQNYQRCLETGELATSE- 156
           Q    H   EE     L+++  +L  T+            A  Q  Q      +L +SE 
Sbjct: 435 QLQASHRESEEALQKRLDEVSRELCHTQSSHASLRADAEKAQEQQQQMAELHSKLQSSEA 494

Query: 157 ------DEAAALRAELRDLELEEARLVQELEDVDR----NNARAAADLQAAQAEAAELDQ 206
                 +E + L  +L++   E ++L + +  ++       AR A D+QA+QAEA +   
Sbjct: 495 EVRSKCEELSGLHGQLQEARAENSQLTERIRSIEALLEAGQARDAQDVQASQAEADQQQT 554

Query: 207 QERQHYRDYSALKRQQLELLDQLGNVENQLQYARVQRDRLKEIN 250
           + ++     S L+++ +EL +    VE Q    +V+ + L+E N
Sbjct: 555 RLKELESQVSGLEKEAIELREA---VEQQ----KVKNNDLREKN 591



 Score = 34.7 bits (78), Expect = 0.17
 Identities = 31/107 (28%), Positives = 52/107 (48%), Gaps = 10/107 (9%)

Query: 144 QRCLETGE--LATSEDEAAALRAELRDLELEEARLVQELEDVDRNNARAAADLQAAQAE- 200
           +R LE  E  LAT +++AA  +++LR+L  E   +  E        A+    L A + E 
Sbjct: 266 KRQLEEKEKLLATEQEDAAVAKSKLRELNKE---MAAEKAKAAAGEAKVKKQLVAREQEI 322

Query: 201 ---AAELDQQERQHYRDYSALKRQQLELLDQLGNVENQLQYARVQRD 244
               A +    R+H ++   L+ +   L +QL N  N  Q AR+Q++
Sbjct: 323 TAVQARMQASYREHVKEVQQLQGKIRTLQEQLENGPN-TQLARLQQE 368


>gi|110611220 ribosome binding protein 1 [Homo sapiens]
          Length = 977

 Score = 39.3 bits (90), Expect = 0.007
 Identities = 39/164 (23%), Positives = 72/164 (43%), Gaps = 30/164 (18%)

Query: 110 QAVVDHPLCEECTDSLLEQLDIQLALTE------------ADSQNYQRCLETGELATSE- 156
           Q    H   EE     L+++  +L  T+            A  Q  Q      +L +SE 
Sbjct: 435 QLQASHRESEEALQKRLDEVSRELCHTQSSHASLRADAEKAQEQQQQMAELHSKLQSSEA 494

Query: 157 ------DEAAALRAELRDLELEEARLVQELEDVDR----NNARAAADLQAAQAEAAELDQ 206
                 +E + L  +L++   E ++L + +  ++       AR A D+QA+QAEA +   
Sbjct: 495 EVRSKCEELSGLHGQLQEARAENSQLTERIRSIEALLEAGQARDAQDVQASQAEADQQQT 554

Query: 207 QERQHYRDYSALKRQQLELLDQLGNVENQLQYARVQRDRLKEIN 250
           + ++     S L+++ +EL +    VE Q    +V+ + L+E N
Sbjct: 555 RLKELESQVSGLEKEAIELREA---VEQQ----KVKNNDLREKN 591



 Score = 34.7 bits (78), Expect = 0.17
 Identities = 31/107 (28%), Positives = 52/107 (48%), Gaps = 10/107 (9%)

Query: 144 QRCLETGE--LATSEDEAAALRAELRDLELEEARLVQELEDVDRNNARAAADLQAAQAE- 200
           +R LE  E  LAT +++AA  +++LR+L  E   +  E        A+    L A + E 
Sbjct: 266 KRQLEEKEKLLATEQEDAAVAKSKLRELNKE---MAAEKAKAAAGEAKVKKQLVAREQEI 322

Query: 201 ---AAELDQQERQHYRDYSALKRQQLELLDQLGNVENQLQYARVQRD 244
               A +    R+H ++   L+ +   L +QL N  N  Q AR+Q++
Sbjct: 323 TAVQARMQASYREHVKEVQQLQGKIRTLQEQLENGPN-TQLARLQQE 368


>gi|205277396 dynactin 1 isoform 4 [Homo sapiens]
          Length = 1139

 Score = 38.9 bits (89), Expect = 0.009
 Identities = 45/148 (30%), Positives = 65/148 (43%), Gaps = 27/148 (18%)

Query: 127 EQLDIQLALTEADSQNYQRCLETGELATSE--DEAAALRAELRDLELEEAR---LVQELE 181
           +Q D+Q  L EA  +  +  LE  E    E  D A A+     D E+ E R   L QE+E
Sbjct: 134 QQADLQRRLKEARKEA-KEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVE 192

Query: 182 DVDRNNARAAADLQAAQAEAAE-----------LDQQERQH---------YRDYSALKRQ 221
            +         DL+  +AE  E           L Q E Q+          RD S+ ++Q
Sbjct: 193 ALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQ 252

Query: 222 QLELLDQLGNVENQ-LQYARVQRDRLKE 248
           +   L +L   +NQ L+  R QR+RL+E
Sbjct: 253 EHVKLQKLMEKKNQELEVVRQQRERLQE 280



 Score = 29.3 bits (64), Expect = 7.2
 Identities = 26/103 (25%), Positives = 45/103 (43%), Gaps = 11/103 (10%)

Query: 152 LATSEDEAAALRAELRDLELEEARLVQELEDVDRNNARAAADLQAAQAEAAELDQQERQH 211
           L +   E   LRA++RDLE       ++LE +    A   A L+  +    +L+Q +   
Sbjct: 76  LPSPSKEEEGLRAQVRDLE-------EKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWK 128

Query: 212 YRDYSALKRQQLELLDQLGNVENQLQYARVQRDRLKEINCFTA 254
               S ++ QQ +L  +L     + + A   ++R  E    TA
Sbjct: 129 ----SKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTA 167


>gi|205277392 dynactin 1 isoform 3 [Homo sapiens]
          Length = 1253

 Score = 38.9 bits (89), Expect = 0.009
 Identities = 45/148 (30%), Positives = 65/148 (43%), Gaps = 27/148 (18%)

Query: 127 EQLDIQLALTEADSQNYQRCLETGELATSE--DEAAALRAELRDLELEEAR---LVQELE 181
           +Q D+Q  L EA  +  +  LE  E    E  D A A+     D E+ E R   L QE+E
Sbjct: 248 QQADLQRRLKEARKEA-KEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVE 306

Query: 182 DVDRNNARAAADLQAAQAEAAE-----------LDQQERQH---------YRDYSALKRQ 221
            +         DL+  +AE  E           L Q E Q+          RD S+ ++Q
Sbjct: 307 ALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQ 366

Query: 222 QLELLDQLGNVENQ-LQYARVQRDRLKE 248
           +   L +L   +NQ L+  R QR+RL+E
Sbjct: 367 EHVKLQKLMEKKNQELEVVRQQRERLQE 394



 Score = 29.3 bits (64), Expect = 7.2
 Identities = 26/103 (25%), Positives = 45/103 (43%), Gaps = 11/103 (10%)

Query: 152 LATSEDEAAALRAELRDLELEEARLVQELEDVDRNNARAAADLQAAQAEAAELDQQERQH 211
           L +   E   LRA++RDLE       ++LE +    A   A L+  +    +L+Q +   
Sbjct: 190 LPSPSKEEEGLRAQVRDLE-------EKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWK 242

Query: 212 YRDYSALKRQQLELLDQLGNVENQLQYARVQRDRLKEINCFTA 254
               S ++ QQ +L  +L     + + A   ++R  E    TA
Sbjct: 243 ----SKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTA 281


>gi|13259508 dynactin 1 isoform 2 [Homo sapiens]
          Length = 1144

 Score = 38.9 bits (89), Expect = 0.009
 Identities = 45/148 (30%), Positives = 65/148 (43%), Gaps = 27/148 (18%)

Query: 127 EQLDIQLALTEADSQNYQRCLETGELATSE--DEAAALRAELRDLELEEAR---LVQELE 181
           +Q D+Q  L EA  +  +  LE  E    E  D A A+     D E+ E R   L QE+E
Sbjct: 134 QQADLQRRLKEARKEA-KEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVE 192

Query: 182 DVDRNNARAAADLQAAQAEAAE-----------LDQQERQH---------YRDYSALKRQ 221
            +         DL+  +AE  E           L Q E Q+          RD S+ ++Q
Sbjct: 193 ALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQ 252

Query: 222 QLELLDQLGNVENQ-LQYARVQRDRLKE 248
           +   L +L   +NQ L+  R QR+RL+E
Sbjct: 253 EHVKLQKLMEKKNQELEVVRQQRERLQE 280



 Score = 29.3 bits (64), Expect = 7.2
 Identities = 26/103 (25%), Positives = 45/103 (43%), Gaps = 11/103 (10%)

Query: 152 LATSEDEAAALRAELRDLELEEARLVQELEDVDRNNARAAADLQAAQAEAAELDQQERQH 211
           L +   E   LRA++RDLE       ++LE +    A   A L+  +    +L+Q +   
Sbjct: 76  LPSPSKEEEGLRAQVRDLE-------EKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWK 128

Query: 212 YRDYSALKRQQLELLDQLGNVENQLQYARVQRDRLKEINCFTA 254
               S ++ QQ +L  +L     + + A   ++R  E    TA
Sbjct: 129 ----SKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTA 167


>gi|13259510 dynactin 1 isoform 1 [Homo sapiens]
          Length = 1278

 Score = 38.9 bits (89), Expect = 0.009
 Identities = 45/148 (30%), Positives = 65/148 (43%), Gaps = 27/148 (18%)

Query: 127 EQLDIQLALTEADSQNYQRCLETGELATSE--DEAAALRAELRDLELEEAR---LVQELE 181
           +Q D+Q  L EA  +  +  LE  E    E  D A A+     D E+ E R   L QE+E
Sbjct: 268 QQADLQRRLKEARKEA-KEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVE 326

Query: 182 DVDRNNARAAADLQAAQAEAAE-----------LDQQERQH---------YRDYSALKRQ 221
            +         DL+  +AE  E           L Q E Q+          RD S+ ++Q
Sbjct: 327 ALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQ 386

Query: 222 QLELLDQLGNVENQ-LQYARVQRDRLKE 248
           +   L +L   +NQ L+  R QR+RL+E
Sbjct: 387 EHVKLQKLMEKKNQELEVVRQQRERLQE 414



 Score = 29.3 bits (64), Expect = 7.2
 Identities = 26/103 (25%), Positives = 45/103 (43%), Gaps = 11/103 (10%)

Query: 152 LATSEDEAAALRAELRDLELEEARLVQELEDVDRNNARAAADLQAAQAEAAELDQQERQH 211
           L +   E   LRA++RDLE       ++LE +    A   A L+  +    +L+Q +   
Sbjct: 210 LPSPSKEEEGLRAQVRDLE-------EKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWK 262

Query: 212 YRDYSALKRQQLELLDQLGNVENQLQYARVQRDRLKEINCFTA 254
               S ++ QQ +L  +L     + + A   ++R  E    TA
Sbjct: 263 ----SKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTA 301


>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
            sapiens]
          Length = 1940

 Score = 38.9 bits (89), Expect = 0.009
 Identities = 41/167 (24%), Positives = 71/167 (42%), Gaps = 29/167 (17%)

Query: 95   SIQKXAGDIFDIVSGQAVVDHPLCEECTDSLLEQLDIQLALTEADSQNYQRCLETGELAT 154
            ++++   D+ + ++      H L +      LE+ DIQLAL EA            E A 
Sbjct: 1505 NLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEA------------EAAL 1552

Query: 155  SEDEAAALRAELR------DLELEEARLVQELEDVDRNNARAAADLQAA-------QAEA 201
              +EA  LR +L       +++ + A   +E+E + RN  R    +Q+A       + EA
Sbjct: 1553 EHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEA 1612

Query: 202  AELDQQERQHYRD----YSALKRQQLELLDQLGNVENQLQYARVQRD 244
              L ++      +     S   RQ  E L  L +V+ QL+  ++  D
Sbjct: 1613 IRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLD 1659



 Score = 32.0 bits (71), Expect = 1.1
 Identities = 30/132 (22%), Positives = 56/132 (42%), Gaps = 12/132 (9%)

Query: 137  EADSQNYQRCLETGELATSEDEAAALRAELRDLELEEARLVQELE-------DVDRNNAR 189
            +A  + +Q+ L+  +L   ED+  +L      LE +   L   LE       D++RN  +
Sbjct: 998  KALQEAHQQALD--DLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRK 1055

Query: 190  AAADLQAAQAEAAELDQQERQHYRDYSALKRQQLELLDQLGNVENQLQYARVQRDRLKEI 249
               DL+ AQ    +L+  ++Q       LK++  E       VE++       + ++KE+
Sbjct: 1056 LEGDLKLAQESILDLENDKQQL---DERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKEL 1112

Query: 250  NCFTATFEIWVE 261
                   E  +E
Sbjct: 1113 QARIEELEEEIE 1124



 Score = 31.6 bits (70), Expect = 1.5
 Identities = 30/105 (28%), Positives = 45/105 (42%), Gaps = 21/105 (20%)

Query: 152  LATSEDEAAALRAELRDLELEEARLVQELE----DVDRNNARAAA--------------- 192
            L  SE++  A+ A+   LE  + RL  E+E    DV+R N+ AAA               
Sbjct: 1398 LQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEW 1457

Query: 193  --DLQAAQAEAAELDQQERQHYRDYSALKRQQLELLDQLGNVENQ 235
                + +QAE     ++ R    +   LK    E LDQL  V+ +
Sbjct: 1458 KTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRE 1502



 Score = 30.8 bits (68), Expect = 2.5
 Identities = 25/134 (18%), Positives = 56/134 (41%), Gaps = 11/134 (8%)

Query: 119  EECTDSLLEQLDIQLALTE----ADSQNYQRCLETGELATSEDEAAALRAELRDLELEEA 174
            E C   +  +  ++  + E    A+ +       T +    EDE + L+ ++ DLEL  A
Sbjct: 904  ERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLA 963

Query: 175  RLVQELEDVDRNNARAAADLQAAQAEAAELDQQERQHYRDYSALKRQQLELLDQLGNVEN 234
            ++ +E    +        +L       A+L ++++       AL+    + LD L   E+
Sbjct: 964  KVEKEKHATENKVKNLTEELSGLDETIAKLTREKK-------ALQEAHQQALDDLQAEED 1016

Query: 235  QLQYARVQRDRLKE 248
            ++      + +L++
Sbjct: 1017 KVNSLNKTKSKLEQ 1030



 Score = 30.4 bits (67), Expect = 3.2
 Identities = 55/257 (21%), Positives = 102/257 (39%), Gaps = 31/257 (12%)

Query: 9    QRCHQALKLSGSSESRSLPAAPAPTSGQAEPGDTREPGVTT--REVTDAEEQQDGASSRS 66
            QR   A +L   SE   L  A   TS Q E    RE       R++ +A  Q +   +  
Sbjct: 1136 QRSDYARELEELSER--LEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVA-- 1191

Query: 67   PPGDGSVSKGHANIFTLLGEL--GAMHMLSSIQKXAGD----IFDIVSGQAVVD------ 114
                 ++ K HA+    LGE       +   ++K   +    I D+ S    V       
Sbjct: 1192 -----ALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANL 1246

Query: 115  HPLCEECTDSLLEQL----DIQLALTEADSQNYQRCLETGELATSEDEAAALRAEL---- 166
              +C    D L E      +IQ +L+E  +Q  +   E GEL+   +E  ++ ++L    
Sbjct: 1247 EKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSK 1306

Query: 167  RDLELEEARLVQELEDVDRNNARAAADLQAAQAEAAELDQQERQHYRDYSALKRQQLELL 226
            +    +   L ++LE+ ++     A  LQ+++ +   L +Q  +     + L+R   +  
Sbjct: 1307 QAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKAN 1366

Query: 227  DQLGNVENQLQYARVQR 243
             ++     + +   +QR
Sbjct: 1367 SEVAQWRTKYETDAIQR 1383


>gi|29171755 PTPRF interacting protein alpha 2 [Homo sapiens]
          Length = 1257

 Score = 38.9 bits (89), Expect = 0.009
 Identities = 31/142 (21%), Positives = 62/142 (43%), Gaps = 7/142 (4%)

Query: 109 GQAVVDHPLCEECTDSLLEQLDIQLALTEADSQNYQRCLETGELATSEDEAAALRAELRD 168
           GQ V +  L     DS  E   I       + QNY       E+A  ++  AAL + + +
Sbjct: 248 GQKVHEKRLSNGSIDSTDETSQIVELQELLEKQNY-------EMAQMKERLAALSSRVGE 300

Query: 169 LELEEARLVQELEDVDRNNARAAADLQAAQAEAAELDQQERQHYRDYSALKRQQLELLDQ 228
           +E E     ++L   +  N +   D++ A A+  +++++     + Y + +R+   + D 
Sbjct: 301 VEQEAETARKDLIKTEEMNTKYQRDIREAMAQKEDMEERITTLEKRYLSAQRESTSIHDM 360

Query: 229 LGNVENQLQYARVQRDRLKEIN 250
              +EN+L        +++E N
Sbjct: 361 NDKLENELANKEAILRQMEEKN 382


>gi|58530840 desmoplakin isoform I [Homo sapiens]
          Length = 2871

 Score = 38.5 bits (88), Expect = 0.012
 Identities = 31/133 (23%), Positives = 59/133 (44%), Gaps = 4/133 (3%)

Query: 119  EECTDSLLEQLDIQLALTEADSQNYQRCLET-GELATSEDEAAALRAELRDLELEEARLV 177
            EE  +  LE  D++   +EADS      LE   +L  S +    L+  + DL+ E   L 
Sbjct: 1722 EELRNLRLEYDDLRRGRSEADSDKNATILELRSQLQISNNRTLELQGLINDLQRERENLR 1781

Query: 178  QELEDVDRNNARAAADLQAAQAEAAELDQQERQHYRDYSALKRQQLELL---DQLGNVEN 234
            QE+E   +    A+  +Q ++ +  ++ Q+          L++ +  L    D+L   ++
Sbjct: 1782 QEIEKFQKQALEASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKS 1841

Query: 235  QLQYARVQRDRLK 247
             L+     + RL+
Sbjct: 1842 TLEAETRVKQRLE 1854


>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
          Length = 4547

 Score = 38.5 bits (88), Expect = 0.012
 Identities = 27/93 (29%), Positives = 45/93 (48%), Gaps = 10/93 (10%)

Query: 139  DSQNYQRCLETGELATSEDEAAALRAELRDLEL---------EEARLVQ-ELEDVDRNNA 188
            D+Q  +R ++       +   A ++A+ R  E          EE R+V+ +LE  +R   
Sbjct: 1410 DAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG 1469

Query: 189  RAAADLQAAQAEAAELDQQERQHYRDYSALKRQ 221
             A  +LQA +A A E + Q+RQ   +   L+RQ
Sbjct: 1470 GAEGELQALRARAEEAEAQKRQAQEEAERLRRQ 1502



 Score = 36.2 bits (82), Expect = 0.059
 Identities = 22/81 (27%), Positives = 41/81 (50%), Gaps = 3/81 (3%)

Query: 151  ELATSEDEAAALRAELRDLELEEARLVQELEDVDRNNARAAADLQAAQAEAAELDQQERQ 210
            E+A ++      + + + +E E  RLV  +E+  R    A   ++  Q E  +L+QQ RQ
Sbjct: 2523 EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQ 2582

Query: 211  H---YRDYSALKRQQLELLDQ 228
                  + +   R+QL+LL++
Sbjct: 2583 QEELLAEENQRLREQLQLLEE 2603



 Score = 35.4 bits (80), Expect = 0.10
 Identities = 29/117 (24%), Positives = 52/117 (44%), Gaps = 3/117 (2%)

Query: 134  ALTEADSQNYQRCLETGELATSEDEAAALRA-ELRDLELEEARLVQELEDVDRNNARAAA 192
            A  +A ++  ++  E      ++ E AALR  +  D E+E+ +  +  E   R  A+   
Sbjct: 2129 AQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHK--KFAEQTLRQKAQVEQ 2186

Query: 193  DLQAAQAEAAELDQQERQHYRDYSALKRQQLELLDQLGNVENQLQYARVQRDRLKEI 249
            +L   + +  E D Q+     +   LK +  E   Q   VE +L   RVQ + L ++
Sbjct: 2187 ELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKL 2243



 Score = 35.0 bits (79), Expect = 0.13
 Identities = 29/109 (26%), Positives = 52/109 (47%), Gaps = 1/109 (0%)

Query: 137  EADSQNYQRCLETGELATSEDEAAALRAELRDLELEEARLVQELEDVDRNNARAAADLQA 196
            E +    QR L   ELA  + EAAA   + ++LE E A++  E+E +  + ARA  + ++
Sbjct: 1721 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS 1780

Query: 197  AQAEAAELDQQERQHYRDYSALKRQQLELLDQLGNVENQLQYARVQRDR 245
               ++ +  + E   +R+  A +  +L  L +    + QL      R R
Sbjct: 1781 TSEKSKQRLEAEAGRFREL-AEEAARLRALAEEAKRQRQLAEEDAARQR 1828



 Score = 34.7 bits (78), Expect = 0.17
 Identities = 36/118 (30%), Positives = 51/118 (43%), Gaps = 5/118 (4%)

Query: 129  LDIQLALTEADSQ-NYQRCLETGELATSEDEAAALRAELRDLELEEARLVQELEDVDRNN 187
            L+ Q  L EA +Q   Q   E  EL     E    R E      ++ R +QE     R +
Sbjct: 1369 LEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQS 1428

Query: 188  ARAAADLQAAQAEAAELDQQERQHYRDYSALKRQQLELLD-QLGNVENQLQYARVQRD 244
            + A    +A QAEAAE   + R    +   + R QLE  + Q G  E +LQ  R + +
Sbjct: 1429 SEAEIQAKARQAEAAE---RSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAE 1483



 Score = 33.5 bits (75), Expect = 0.38
 Identities = 36/132 (27%), Positives = 67/132 (50%), Gaps = 17/132 (12%)

Query: 128  QLDIQLALTEADSQNYQRCLETGELA--TSEDEAAALRAELRDLELEEARLVQELEDVDR 185
            +L+ Q  L E D+   +R +E   LA   S ++AAA +AEL   ELE  R+    ED  R
Sbjct: 1905 ELERQKGLVE-DTLRQRRQVEEEILALKASFEKAAAGKAEL---ELELGRIRSNAEDTLR 1960

Query: 186  NNARAAADLQAAQAEAAELDQQERQHYRDYSALK---------RQQLELLDQLGNVENQL 236
              ++  A+L+AA+      +++ R+   +    K         RQ+   L+++  ++ ++
Sbjct: 1961 --SKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKV 2018

Query: 237  QYARVQRDRLKE 248
            + AR  R+R ++
Sbjct: 2019 EEARRLRERAEQ 2030



 Score = 29.6 bits (65), Expect = 5.5
 Identities = 31/119 (26%), Positives = 52/119 (43%), Gaps = 11/119 (9%)

Query: 135  LTEADSQNYQRCLETGELAT-----SEDEAAALRAELRDLELEEARLVQELEDVDRNNAR 189
            L E   Q   R L+  + A      +E++A A   + ++ EL++  L QE   +D+    
Sbjct: 2024 LRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT-LQQEQSVLDQLRGE 2082

Query: 190  AAADLQAAQAEAAELDQQERQHYRDYSALKRQQLELLDQLGNVENQLQYARVQRDRLKE 248
            A A  +AA+       Q ER+     +A  R+Q+E  ++L     +   AR Q     E
Sbjct: 2083 AEAARRAAEEAEEARVQAERE-----AAQSRRQVEEAERLKQSAEEQAQARAQAQAAAE 2136


>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
          Length = 4551

 Score = 38.5 bits (88), Expect = 0.012
 Identities = 27/93 (29%), Positives = 45/93 (48%), Gaps = 10/93 (10%)

Query: 139  DSQNYQRCLETGELATSEDEAAALRAELRDLEL---------EEARLVQ-ELEDVDRNNA 188
            D+Q  +R ++       +   A ++A+ R  E          EE R+V+ +LE  +R   
Sbjct: 1414 DAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG 1473

Query: 189  RAAADLQAAQAEAAELDQQERQHYRDYSALKRQ 221
             A  +LQA +A A E + Q+RQ   +   L+RQ
Sbjct: 1474 GAEGELQALRARAEEAEAQKRQAQEEAERLRRQ 1506



 Score = 36.2 bits (82), Expect = 0.059
 Identities = 22/81 (27%), Positives = 41/81 (50%), Gaps = 3/81 (3%)

Query: 151  ELATSEDEAAALRAELRDLELEEARLVQELEDVDRNNARAAADLQAAQAEAAELDQQERQ 210
            E+A ++      + + + +E E  RLV  +E+  R    A   ++  Q E  +L+QQ RQ
Sbjct: 2527 EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQ 2586

Query: 211  H---YRDYSALKRQQLELLDQ 228
                  + +   R+QL+LL++
Sbjct: 2587 QEELLAEENQRLREQLQLLEE 2607



 Score = 35.4 bits (80), Expect = 0.10
 Identities = 29/117 (24%), Positives = 52/117 (44%), Gaps = 3/117 (2%)

Query: 134  ALTEADSQNYQRCLETGELATSEDEAAALRA-ELRDLELEEARLVQELEDVDRNNARAAA 192
            A  +A ++  ++  E      ++ E AALR  +  D E+E+ +  +  E   R  A+   
Sbjct: 2133 AQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHK--KFAEQTLRQKAQVEQ 2190

Query: 193  DLQAAQAEAAELDQQERQHYRDYSALKRQQLELLDQLGNVENQLQYARVQRDRLKEI 249
            +L   + +  E D Q+     +   LK +  E   Q   VE +L   RVQ + L ++
Sbjct: 2191 ELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKL 2247



 Score = 35.0 bits (79), Expect = 0.13
 Identities = 29/109 (26%), Positives = 52/109 (47%), Gaps = 1/109 (0%)

Query: 137  EADSQNYQRCLETGELATSEDEAAALRAELRDLELEEARLVQELEDVDRNNARAAADLQA 196
            E +    QR L   ELA  + EAAA   + ++LE E A++  E+E +  + ARA  + ++
Sbjct: 1725 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS 1784

Query: 197  AQAEAAELDQQERQHYRDYSALKRQQLELLDQLGNVENQLQYARVQRDR 245
               ++ +  + E   +R+  A +  +L  L +    + QL      R R
Sbjct: 1785 TSEKSKQRLEAEAGRFREL-AEEAARLRALAEEAKRQRQLAEEDAARQR 1832



 Score = 34.7 bits (78), Expect = 0.17
 Identities = 36/118 (30%), Positives = 51/118 (43%), Gaps = 5/118 (4%)

Query: 129  LDIQLALTEADSQ-NYQRCLETGELATSEDEAAALRAELRDLELEEARLVQELEDVDRNN 187
            L+ Q  L EA +Q   Q   E  EL     E    R E      ++ R +QE     R +
Sbjct: 1373 LEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQS 1432

Query: 188  ARAAADLQAAQAEAAELDQQERQHYRDYSALKRQQLELLD-QLGNVENQLQYARVQRD 244
            + A    +A QAEAAE   + R    +   + R QLE  + Q G  E +LQ  R + +
Sbjct: 1433 SEAEIQAKARQAEAAE---RSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAE 1487



 Score = 33.5 bits (75), Expect = 0.38
 Identities = 36/132 (27%), Positives = 67/132 (50%), Gaps = 17/132 (12%)

Query: 128  QLDIQLALTEADSQNYQRCLETGELA--TSEDEAAALRAELRDLELEEARLVQELEDVDR 185
            +L+ Q  L E D+   +R +E   LA   S ++AAA +AEL   ELE  R+    ED  R
Sbjct: 1909 ELERQKGLVE-DTLRQRRQVEEEILALKASFEKAAAGKAEL---ELELGRIRSNAEDTLR 1964

Query: 186  NNARAAADLQAAQAEAAELDQQERQHYRDYSALK---------RQQLELLDQLGNVENQL 236
              ++  A+L+AA+      +++ R+   +    K         RQ+   L+++  ++ ++
Sbjct: 1965 --SKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKV 2022

Query: 237  QYARVQRDRLKE 248
            + AR  R+R ++
Sbjct: 2023 EEARRLRERAEQ 2034



 Score = 29.6 bits (65), Expect = 5.5
 Identities = 31/119 (26%), Positives = 52/119 (43%), Gaps = 11/119 (9%)

Query: 135  LTEADSQNYQRCLETGELAT-----SEDEAAALRAELRDLELEEARLVQELEDVDRNNAR 189
            L E   Q   R L+  + A      +E++A A   + ++ EL++  L QE   +D+    
Sbjct: 2028 LRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT-LQQEQSVLDQLRGE 2086

Query: 190  AAADLQAAQAEAAELDQQERQHYRDYSALKRQQLELLDQLGNVENQLQYARVQRDRLKE 248
            A A  +AA+       Q ER+     +A  R+Q+E  ++L     +   AR Q     E
Sbjct: 2087 AEAARRAAEEAEEARVQAERE-----AAQSRRQVEEAERLKQSAEEQAQARAQAQAAAE 2140


>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
          Length = 4547

 Score = 38.5 bits (88), Expect = 0.012
 Identities = 27/93 (29%), Positives = 45/93 (48%), Gaps = 10/93 (10%)

Query: 139  DSQNYQRCLETGELATSEDEAAALRAELRDLEL---------EEARLVQ-ELEDVDRNNA 188
            D+Q  +R ++       +   A ++A+ R  E          EE R+V+ +LE  +R   
Sbjct: 1410 DAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG 1469

Query: 189  RAAADLQAAQAEAAELDQQERQHYRDYSALKRQ 221
             A  +LQA +A A E + Q+RQ   +   L+RQ
Sbjct: 1470 GAEGELQALRARAEEAEAQKRQAQEEAERLRRQ 1502



 Score = 36.2 bits (82), Expect = 0.059
 Identities = 22/81 (27%), Positives = 41/81 (50%), Gaps = 3/81 (3%)

Query: 151  ELATSEDEAAALRAELRDLELEEARLVQELEDVDRNNARAAADLQAAQAEAAELDQQERQ 210
            E+A ++      + + + +E E  RLV  +E+  R    A   ++  Q E  +L+QQ RQ
Sbjct: 2523 EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQ 2582

Query: 211  H---YRDYSALKRQQLELLDQ 228
                  + +   R+QL+LL++
Sbjct: 2583 QEELLAEENQRLREQLQLLEE 2603



 Score = 35.4 bits (80), Expect = 0.10
 Identities = 29/117 (24%), Positives = 52/117 (44%), Gaps = 3/117 (2%)

Query: 134  ALTEADSQNYQRCLETGELATSEDEAAALRA-ELRDLELEEARLVQELEDVDRNNARAAA 192
            A  +A ++  ++  E      ++ E AALR  +  D E+E+ +  +  E   R  A+   
Sbjct: 2129 AQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHK--KFAEQTLRQKAQVEQ 2186

Query: 193  DLQAAQAEAAELDQQERQHYRDYSALKRQQLELLDQLGNVENQLQYARVQRDRLKEI 249
            +L   + +  E D Q+     +   LK +  E   Q   VE +L   RVQ + L ++
Sbjct: 2187 ELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKL 2243



 Score = 35.0 bits (79), Expect = 0.13
 Identities = 29/109 (26%), Positives = 52/109 (47%), Gaps = 1/109 (0%)

Query: 137  EADSQNYQRCLETGELATSEDEAAALRAELRDLELEEARLVQELEDVDRNNARAAADLQA 196
            E +    QR L   ELA  + EAAA   + ++LE E A++  E+E +  + ARA  + ++
Sbjct: 1721 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS 1780

Query: 197  AQAEAAELDQQERQHYRDYSALKRQQLELLDQLGNVENQLQYARVQRDR 245
               ++ +  + E   +R+  A +  +L  L +    + QL      R R
Sbjct: 1781 TSEKSKQRLEAEAGRFREL-AEEAARLRALAEEAKRQRQLAEEDAARQR 1828



 Score = 34.7 bits (78), Expect = 0.17
 Identities = 36/118 (30%), Positives = 51/118 (43%), Gaps = 5/118 (4%)

Query: 129  LDIQLALTEADSQ-NYQRCLETGELATSEDEAAALRAELRDLELEEARLVQELEDVDRNN 187
            L+ Q  L EA +Q   Q   E  EL     E    R E      ++ R +QE     R +
Sbjct: 1369 LEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQS 1428

Query: 188  ARAAADLQAAQAEAAELDQQERQHYRDYSALKRQQLELLD-QLGNVENQLQYARVQRD 244
            + A    +A QAEAAE   + R    +   + R QLE  + Q G  E +LQ  R + +
Sbjct: 1429 SEAEIQAKARQAEAAE---RSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAE 1483



 Score = 33.5 bits (75), Expect = 0.38
 Identities = 36/132 (27%), Positives = 67/132 (50%), Gaps = 17/132 (12%)

Query: 128  QLDIQLALTEADSQNYQRCLETGELA--TSEDEAAALRAELRDLELEEARLVQELEDVDR 185
            +L+ Q  L E D+   +R +E   LA   S ++AAA +AEL   ELE  R+    ED  R
Sbjct: 1905 ELERQKGLVE-DTLRQRRQVEEEILALKASFEKAAAGKAEL---ELELGRIRSNAEDTLR 1960

Query: 186  NNARAAADLQAAQAEAAELDQQERQHYRDYSALK---------RQQLELLDQLGNVENQL 236
              ++  A+L+AA+      +++ R+   +    K         RQ+   L+++  ++ ++
Sbjct: 1961 --SKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKV 2018

Query: 237  QYARVQRDRLKE 248
            + AR  R+R ++
Sbjct: 2019 EEARRLRERAEQ 2030



 Score = 29.6 bits (65), Expect = 5.5
 Identities = 31/119 (26%), Positives = 52/119 (43%), Gaps = 11/119 (9%)

Query: 135  LTEADSQNYQRCLETGELAT-----SEDEAAALRAELRDLELEEARLVQELEDVDRNNAR 189
            L E   Q   R L+  + A      +E++A A   + ++ EL++  L QE   +D+    
Sbjct: 2024 LRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT-LQQEQSVLDQLRGE 2082

Query: 190  AAADLQAAQAEAAELDQQERQHYRDYSALKRQQLELLDQLGNVENQLQYARVQRDRLKE 248
            A A  +AA+       Q ER+     +A  R+Q+E  ++L     +   AR Q     E
Sbjct: 2083 AEAARRAAEEAEEARVQAERE-----AAQSRRQVEEAERLKQSAEEQAQARAQAQAAAE 2136


>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
          Length = 4515

 Score = 38.5 bits (88), Expect = 0.012
 Identities = 27/93 (29%), Positives = 45/93 (48%), Gaps = 10/93 (10%)

Query: 139  DSQNYQRCLETGELATSEDEAAALRAELRDLEL---------EEARLVQ-ELEDVDRNNA 188
            D+Q  +R ++       +   A ++A+ R  E          EE R+V+ +LE  +R   
Sbjct: 1378 DAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG 1437

Query: 189  RAAADLQAAQAEAAELDQQERQHYRDYSALKRQ 221
             A  +LQA +A A E + Q+RQ   +   L+RQ
Sbjct: 1438 GAEGELQALRARAEEAEAQKRQAQEEAERLRRQ 1470



 Score = 36.2 bits (82), Expect = 0.059
 Identities = 22/81 (27%), Positives = 41/81 (50%), Gaps = 3/81 (3%)

Query: 151  ELATSEDEAAALRAELRDLELEEARLVQELEDVDRNNARAAADLQAAQAEAAELDQQERQ 210
            E+A ++      + + + +E E  RLV  +E+  R    A   ++  Q E  +L+QQ RQ
Sbjct: 2491 EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQ 2550

Query: 211  H---YRDYSALKRQQLELLDQ 228
                  + +   R+QL+LL++
Sbjct: 2551 QEELLAEENQRLREQLQLLEE 2571



 Score = 35.4 bits (80), Expect = 0.10
 Identities = 29/117 (24%), Positives = 52/117 (44%), Gaps = 3/117 (2%)

Query: 134  ALTEADSQNYQRCLETGELATSEDEAAALRA-ELRDLELEEARLVQELEDVDRNNARAAA 192
            A  +A ++  ++  E      ++ E AALR  +  D E+E+ +  +  E   R  A+   
Sbjct: 2097 AQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHK--KFAEQTLRQKAQVEQ 2154

Query: 193  DLQAAQAEAAELDQQERQHYRDYSALKRQQLELLDQLGNVENQLQYARVQRDRLKEI 249
            +L   + +  E D Q+     +   LK +  E   Q   VE +L   RVQ + L ++
Sbjct: 2155 ELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKL 2211



 Score = 35.0 bits (79), Expect = 0.13
 Identities = 29/109 (26%), Positives = 52/109 (47%), Gaps = 1/109 (0%)

Query: 137  EADSQNYQRCLETGELATSEDEAAALRAELRDLELEEARLVQELEDVDRNNARAAADLQA 196
            E +    QR L   ELA  + EAAA   + ++LE E A++  E+E +  + ARA  + ++
Sbjct: 1689 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS 1748

Query: 197  AQAEAAELDQQERQHYRDYSALKRQQLELLDQLGNVENQLQYARVQRDR 245
               ++ +  + E   +R+  A +  +L  L +    + QL      R R
Sbjct: 1749 TSEKSKQRLEAEAGRFREL-AEEAARLRALAEEAKRQRQLAEEDAARQR 1796



 Score = 34.7 bits (78), Expect = 0.17
 Identities = 36/118 (30%), Positives = 51/118 (43%), Gaps = 5/118 (4%)

Query: 129  LDIQLALTEADSQ-NYQRCLETGELATSEDEAAALRAELRDLELEEARLVQELEDVDRNN 187
            L+ Q  L EA +Q   Q   E  EL     E    R E      ++ R +QE     R +
Sbjct: 1337 LEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQS 1396

Query: 188  ARAAADLQAAQAEAAELDQQERQHYRDYSALKRQQLELLD-QLGNVENQLQYARVQRD 244
            + A    +A QAEAAE   + R    +   + R QLE  + Q G  E +LQ  R + +
Sbjct: 1397 SEAEIQAKARQAEAAE---RSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAE 1451



 Score = 33.5 bits (75), Expect = 0.38
 Identities = 36/132 (27%), Positives = 67/132 (50%), Gaps = 17/132 (12%)

Query: 128  QLDIQLALTEADSQNYQRCLETGELA--TSEDEAAALRAELRDLELEEARLVQELEDVDR 185
            +L+ Q  L E D+   +R +E   LA   S ++AAA +AEL   ELE  R+    ED  R
Sbjct: 1873 ELERQKGLVE-DTLRQRRQVEEEILALKASFEKAAAGKAEL---ELELGRIRSNAEDTLR 1928

Query: 186  NNARAAADLQAAQAEAAELDQQERQHYRDYSALK---------RQQLELLDQLGNVENQL 236
              ++  A+L+AA+      +++ R+   +    K         RQ+   L+++  ++ ++
Sbjct: 1929 --SKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKV 1986

Query: 237  QYARVQRDRLKE 248
            + AR  R+R ++
Sbjct: 1987 EEARRLRERAEQ 1998



 Score = 29.6 bits (65), Expect = 5.5
 Identities = 31/119 (26%), Positives = 52/119 (43%), Gaps = 11/119 (9%)

Query: 135  LTEADSQNYQRCLETGELAT-----SEDEAAALRAELRDLELEEARLVQELEDVDRNNAR 189
            L E   Q   R L+  + A      +E++A A   + ++ EL++  L QE   +D+    
Sbjct: 1992 LRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT-LQQEQSVLDQLRGE 2050

Query: 190  AAADLQAAQAEAAELDQQERQHYRDYSALKRQQLELLDQLGNVENQLQYARVQRDRLKE 248
            A A  +AA+       Q ER+     +A  R+Q+E  ++L     +   AR Q     E
Sbjct: 2051 AEAARRAAEEAEEARVQAERE-----AAQSRRQVEEAERLKQSAEEQAQARAQAQAAAE 2104


>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
          Length = 4684

 Score = 38.5 bits (88), Expect = 0.012
 Identities = 27/93 (29%), Positives = 45/93 (48%), Gaps = 10/93 (10%)

Query: 139  DSQNYQRCLETGELATSEDEAAALRAELRDLEL---------EEARLVQ-ELEDVDRNNA 188
            D+Q  +R ++       +   A ++A+ R  E          EE R+V+ +LE  +R   
Sbjct: 1547 DAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG 1606

Query: 189  RAAADLQAAQAEAAELDQQERQHYRDYSALKRQ 221
             A  +LQA +A A E + Q+RQ   +   L+RQ
Sbjct: 1607 GAEGELQALRARAEEAEAQKRQAQEEAERLRRQ 1639



 Score = 36.2 bits (82), Expect = 0.059
 Identities = 22/81 (27%), Positives = 41/81 (50%), Gaps = 3/81 (3%)

Query: 151  ELATSEDEAAALRAELRDLELEEARLVQELEDVDRNNARAAADLQAAQAEAAELDQQERQ 210
            E+A ++      + + + +E E  RLV  +E+  R    A   ++  Q E  +L+QQ RQ
Sbjct: 2660 EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQ 2719

Query: 211  H---YRDYSALKRQQLELLDQ 228
                  + +   R+QL+LL++
Sbjct: 2720 QEELLAEENQRLREQLQLLEE 2740



 Score = 35.4 bits (80), Expect = 0.10
 Identities = 29/117 (24%), Positives = 52/117 (44%), Gaps = 3/117 (2%)

Query: 134  ALTEADSQNYQRCLETGELATSEDEAAALRA-ELRDLELEEARLVQELEDVDRNNARAAA 192
            A  +A ++  ++  E      ++ E AALR  +  D E+E+ +  +  E   R  A+   
Sbjct: 2266 AQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHK--KFAEQTLRQKAQVEQ 2323

Query: 193  DLQAAQAEAAELDQQERQHYRDYSALKRQQLELLDQLGNVENQLQYARVQRDRLKEI 249
            +L   + +  E D Q+     +   LK +  E   Q   VE +L   RVQ + L ++
Sbjct: 2324 ELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKL 2380



 Score = 35.0 bits (79), Expect = 0.13
 Identities = 29/109 (26%), Positives = 52/109 (47%), Gaps = 1/109 (0%)

Query: 137  EADSQNYQRCLETGELATSEDEAAALRAELRDLELEEARLVQELEDVDRNNARAAADLQA 196
            E +    QR L   ELA  + EAAA   + ++LE E A++  E+E +  + ARA  + ++
Sbjct: 1858 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS 1917

Query: 197  AQAEAAELDQQERQHYRDYSALKRQQLELLDQLGNVENQLQYARVQRDR 245
               ++ +  + E   +R+  A +  +L  L +    + QL      R R
Sbjct: 1918 TSEKSKQRLEAEAGRFREL-AEEAARLRALAEEAKRQRQLAEEDAARQR 1965



 Score = 34.7 bits (78), Expect = 0.17
 Identities = 36/118 (30%), Positives = 51/118 (43%), Gaps = 5/118 (4%)

Query: 129  LDIQLALTEADSQ-NYQRCLETGELATSEDEAAALRAELRDLELEEARLVQELEDVDRNN 187
            L+ Q  L EA +Q   Q   E  EL     E    R E      ++ R +QE     R +
Sbjct: 1506 LEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQS 1565

Query: 188  ARAAADLQAAQAEAAELDQQERQHYRDYSALKRQQLELLD-QLGNVENQLQYARVQRD 244
            + A    +A QAEAAE   + R    +   + R QLE  + Q G  E +LQ  R + +
Sbjct: 1566 SEAEIQAKARQAEAAE---RSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAE 1620



 Score = 33.5 bits (75), Expect = 0.38
 Identities = 36/132 (27%), Positives = 67/132 (50%), Gaps = 17/132 (12%)

Query: 128  QLDIQLALTEADSQNYQRCLETGELA--TSEDEAAALRAELRDLELEEARLVQELEDVDR 185
            +L+ Q  L E D+   +R +E   LA   S ++AAA +AEL   ELE  R+    ED  R
Sbjct: 2042 ELERQKGLVE-DTLRQRRQVEEEILALKASFEKAAAGKAEL---ELELGRIRSNAEDTLR 2097

Query: 186  NNARAAADLQAAQAEAAELDQQERQHYRDYSALK---------RQQLELLDQLGNVENQL 236
              ++  A+L+AA+      +++ R+   +    K         RQ+   L+++  ++ ++
Sbjct: 2098 --SKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKV 2155

Query: 237  QYARVQRDRLKE 248
            + AR  R+R ++
Sbjct: 2156 EEARRLRERAEQ 2167



 Score = 29.6 bits (65), Expect = 5.5
 Identities = 31/119 (26%), Positives = 52/119 (43%), Gaps = 11/119 (9%)

Query: 135  LTEADSQNYQRCLETGELAT-----SEDEAAALRAELRDLELEEARLVQELEDVDRNNAR 189
            L E   Q   R L+  + A      +E++A A   + ++ EL++  L QE   +D+    
Sbjct: 2161 LRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT-LQQEQSVLDQLRGE 2219

Query: 190  AAADLQAAQAEAAELDQQERQHYRDYSALKRQQLELLDQLGNVENQLQYARVQRDRLKE 248
            A A  +AA+       Q ER+     +A  R+Q+E  ++L     +   AR Q     E
Sbjct: 2220 AEAARRAAEEAEEARVQAERE-----AAQSRRQVEEAERLKQSAEEQAQARAQAQAAAE 2273


>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
          Length = 4525

 Score = 38.5 bits (88), Expect = 0.012
 Identities = 27/93 (29%), Positives = 45/93 (48%), Gaps = 10/93 (10%)

Query: 139  DSQNYQRCLETGELATSEDEAAALRAELRDLEL---------EEARLVQ-ELEDVDRNNA 188
            D+Q  +R ++       +   A ++A+ R  E          EE R+V+ +LE  +R   
Sbjct: 1388 DAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG 1447

Query: 189  RAAADLQAAQAEAAELDQQERQHYRDYSALKRQ 221
             A  +LQA +A A E + Q+RQ   +   L+RQ
Sbjct: 1448 GAEGELQALRARAEEAEAQKRQAQEEAERLRRQ 1480



 Score = 36.2 bits (82), Expect = 0.059
 Identities = 22/81 (27%), Positives = 41/81 (50%), Gaps = 3/81 (3%)

Query: 151  ELATSEDEAAALRAELRDLELEEARLVQELEDVDRNNARAAADLQAAQAEAAELDQQERQ 210
            E+A ++      + + + +E E  RLV  +E+  R    A   ++  Q E  +L+QQ RQ
Sbjct: 2501 EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQ 2560

Query: 211  H---YRDYSALKRQQLELLDQ 228
                  + +   R+QL+LL++
Sbjct: 2561 QEELLAEENQRLREQLQLLEE 2581



 Score = 35.4 bits (80), Expect = 0.10
 Identities = 29/117 (24%), Positives = 52/117 (44%), Gaps = 3/117 (2%)

Query: 134  ALTEADSQNYQRCLETGELATSEDEAAALRA-ELRDLELEEARLVQELEDVDRNNARAAA 192
            A  +A ++  ++  E      ++ E AALR  +  D E+E+ +  +  E   R  A+   
Sbjct: 2107 AQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHK--KFAEQTLRQKAQVEQ 2164

Query: 193  DLQAAQAEAAELDQQERQHYRDYSALKRQQLELLDQLGNVENQLQYARVQRDRLKEI 249
            +L   + +  E D Q+     +   LK +  E   Q   VE +L   RVQ + L ++
Sbjct: 2165 ELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKL 2221



 Score = 35.0 bits (79), Expect = 0.13
 Identities = 29/109 (26%), Positives = 52/109 (47%), Gaps = 1/109 (0%)

Query: 137  EADSQNYQRCLETGELATSEDEAAALRAELRDLELEEARLVQELEDVDRNNARAAADLQA 196
            E +    QR L   ELA  + EAAA   + ++LE E A++  E+E +  + ARA  + ++
Sbjct: 1699 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS 1758

Query: 197  AQAEAAELDQQERQHYRDYSALKRQQLELLDQLGNVENQLQYARVQRDR 245
               ++ +  + E   +R+  A +  +L  L +    + QL      R R
Sbjct: 1759 TSEKSKQRLEAEAGRFREL-AEEAARLRALAEEAKRQRQLAEEDAARQR 1806



 Score = 34.7 bits (78), Expect = 0.17
 Identities = 36/118 (30%), Positives = 51/118 (43%), Gaps = 5/118 (4%)

Query: 129  LDIQLALTEADSQ-NYQRCLETGELATSEDEAAALRAELRDLELEEARLVQELEDVDRNN 187
            L+ Q  L EA +Q   Q   E  EL     E    R E      ++ R +QE     R +
Sbjct: 1347 LEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQS 1406

Query: 188  ARAAADLQAAQAEAAELDQQERQHYRDYSALKRQQLELLD-QLGNVENQLQYARVQRD 244
            + A    +A QAEAAE   + R    +   + R QLE  + Q G  E +LQ  R + +
Sbjct: 1407 SEAEIQAKARQAEAAE---RSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAE 1461



 Score = 33.5 bits (75), Expect = 0.38
 Identities = 36/132 (27%), Positives = 67/132 (50%), Gaps = 17/132 (12%)

Query: 128  QLDIQLALTEADSQNYQRCLETGELA--TSEDEAAALRAELRDLELEEARLVQELEDVDR 185
            +L+ Q  L E D+   +R +E   LA   S ++AAA +AEL   ELE  R+    ED  R
Sbjct: 1883 ELERQKGLVE-DTLRQRRQVEEEILALKASFEKAAAGKAEL---ELELGRIRSNAEDTLR 1938

Query: 186  NNARAAADLQAAQAEAAELDQQERQHYRDYSALK---------RQQLELLDQLGNVENQL 236
              ++  A+L+AA+      +++ R+   +    K         RQ+   L+++  ++ ++
Sbjct: 1939 --SKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKV 1996

Query: 237  QYARVQRDRLKE 248
            + AR  R+R ++
Sbjct: 1997 EEARRLRERAEQ 2008



 Score = 29.6 bits (65), Expect = 5.5
 Identities = 31/119 (26%), Positives = 52/119 (43%), Gaps = 11/119 (9%)

Query: 135  LTEADSQNYQRCLETGELAT-----SEDEAAALRAELRDLELEEARLVQELEDVDRNNAR 189
            L E   Q   R L+  + A      +E++A A   + ++ EL++  L QE   +D+    
Sbjct: 2002 LRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT-LQQEQSVLDQLRGE 2060

Query: 190  AAADLQAAQAEAAELDQQERQHYRDYSALKRQQLELLDQLGNVENQLQYARVQRDRLKE 248
            A A  +AA+       Q ER+     +A  R+Q+E  ++L     +   AR Q     E
Sbjct: 2061 AEAARRAAEEAEEARVQAERE-----AAQSRRQVEEAERLKQSAEEQAQARAQAQAAAE 2114


>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
          Length = 4533

 Score = 38.5 bits (88), Expect = 0.012
 Identities = 27/93 (29%), Positives = 45/93 (48%), Gaps = 10/93 (10%)

Query: 139  DSQNYQRCLETGELATSEDEAAALRAELRDLEL---------EEARLVQ-ELEDVDRNNA 188
            D+Q  +R ++       +   A ++A+ R  E          EE R+V+ +LE  +R   
Sbjct: 1396 DAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG 1455

Query: 189  RAAADLQAAQAEAAELDQQERQHYRDYSALKRQ 221
             A  +LQA +A A E + Q+RQ   +   L+RQ
Sbjct: 1456 GAEGELQALRARAEEAEAQKRQAQEEAERLRRQ 1488



 Score = 36.2 bits (82), Expect = 0.059
 Identities = 22/81 (27%), Positives = 41/81 (50%), Gaps = 3/81 (3%)

Query: 151  ELATSEDEAAALRAELRDLELEEARLVQELEDVDRNNARAAADLQAAQAEAAELDQQERQ 210
            E+A ++      + + + +E E  RLV  +E+  R    A   ++  Q E  +L+QQ RQ
Sbjct: 2509 EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQ 2568

Query: 211  H---YRDYSALKRQQLELLDQ 228
                  + +   R+QL+LL++
Sbjct: 2569 QEELLAEENQRLREQLQLLEE 2589



 Score = 35.4 bits (80), Expect = 0.10
 Identities = 29/117 (24%), Positives = 52/117 (44%), Gaps = 3/117 (2%)

Query: 134  ALTEADSQNYQRCLETGELATSEDEAAALRA-ELRDLELEEARLVQELEDVDRNNARAAA 192
            A  +A ++  ++  E      ++ E AALR  +  D E+E+ +  +  E   R  A+   
Sbjct: 2115 AQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHK--KFAEQTLRQKAQVEQ 2172

Query: 193  DLQAAQAEAAELDQQERQHYRDYSALKRQQLELLDQLGNVENQLQYARVQRDRLKEI 249
            +L   + +  E D Q+     +   LK +  E   Q   VE +L   RVQ + L ++
Sbjct: 2173 ELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKL 2229



 Score = 35.0 bits (79), Expect = 0.13
 Identities = 29/109 (26%), Positives = 52/109 (47%), Gaps = 1/109 (0%)

Query: 137  EADSQNYQRCLETGELATSEDEAAALRAELRDLELEEARLVQELEDVDRNNARAAADLQA 196
            E +    QR L   ELA  + EAAA   + ++LE E A++  E+E +  + ARA  + ++
Sbjct: 1707 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS 1766

Query: 197  AQAEAAELDQQERQHYRDYSALKRQQLELLDQLGNVENQLQYARVQRDR 245
               ++ +  + E   +R+  A +  +L  L +    + QL      R R
Sbjct: 1767 TSEKSKQRLEAEAGRFREL-AEEAARLRALAEEAKRQRQLAEEDAARQR 1814



 Score = 34.7 bits (78), Expect = 0.17
 Identities = 36/118 (30%), Positives = 51/118 (43%), Gaps = 5/118 (4%)

Query: 129  LDIQLALTEADSQ-NYQRCLETGELATSEDEAAALRAELRDLELEEARLVQELEDVDRNN 187
            L+ Q  L EA +Q   Q   E  EL     E    R E      ++ R +QE     R +
Sbjct: 1355 LEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQS 1414

Query: 188  ARAAADLQAAQAEAAELDQQERQHYRDYSALKRQQLELLD-QLGNVENQLQYARVQRD 244
            + A    +A QAEAAE   + R    +   + R QLE  + Q G  E +LQ  R + +
Sbjct: 1415 SEAEIQAKARQAEAAE---RSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAE 1469



 Score = 33.5 bits (75), Expect = 0.38
 Identities = 36/132 (27%), Positives = 67/132 (50%), Gaps = 17/132 (12%)

Query: 128  QLDIQLALTEADSQNYQRCLETGELA--TSEDEAAALRAELRDLELEEARLVQELEDVDR 185
            +L+ Q  L E D+   +R +E   LA   S ++AAA +AEL   ELE  R+    ED  R
Sbjct: 1891 ELERQKGLVE-DTLRQRRQVEEEILALKASFEKAAAGKAEL---ELELGRIRSNAEDTLR 1946

Query: 186  NNARAAADLQAAQAEAAELDQQERQHYRDYSALK---------RQQLELLDQLGNVENQL 236
              ++  A+L+AA+      +++ R+   +    K         RQ+   L+++  ++ ++
Sbjct: 1947 --SKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKV 2004

Query: 237  QYARVQRDRLKE 248
            + AR  R+R ++
Sbjct: 2005 EEARRLRERAEQ 2016



 Score = 29.6 bits (65), Expect = 5.5
 Identities = 31/119 (26%), Positives = 52/119 (43%), Gaps = 11/119 (9%)

Query: 135  LTEADSQNYQRCLETGELAT-----SEDEAAALRAELRDLELEEARLVQELEDVDRNNAR 189
            L E   Q   R L+  + A      +E++A A   + ++ EL++  L QE   +D+    
Sbjct: 2010 LRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT-LQQEQSVLDQLRGE 2068

Query: 190  AAADLQAAQAEAAELDQQERQHYRDYSALKRQQLELLDQLGNVENQLQYARVQRDRLKE 248
            A A  +AA+       Q ER+     +A  R+Q+E  ++L     +   AR Q     E
Sbjct: 2069 AEAARRAAEEAEEARVQAERE-----AAQSRRQVEEAERLKQSAEEQAQARAQAQAAAE 2122


>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
          Length = 4574

 Score = 38.5 bits (88), Expect = 0.012
 Identities = 27/93 (29%), Positives = 45/93 (48%), Gaps = 10/93 (10%)

Query: 139  DSQNYQRCLETGELATSEDEAAALRAELRDLEL---------EEARLVQ-ELEDVDRNNA 188
            D+Q  +R ++       +   A ++A+ R  E          EE R+V+ +LE  +R   
Sbjct: 1437 DAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG 1496

Query: 189  RAAADLQAAQAEAAELDQQERQHYRDYSALKRQ 221
             A  +LQA +A A E + Q+RQ   +   L+RQ
Sbjct: 1497 GAEGELQALRARAEEAEAQKRQAQEEAERLRRQ 1529



 Score = 36.2 bits (82), Expect = 0.059
 Identities = 22/81 (27%), Positives = 41/81 (50%), Gaps = 3/81 (3%)

Query: 151  ELATSEDEAAALRAELRDLELEEARLVQELEDVDRNNARAAADLQAAQAEAAELDQQERQ 210
            E+A ++      + + + +E E  RLV  +E+  R    A   ++  Q E  +L+QQ RQ
Sbjct: 2550 EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQ 2609

Query: 211  H---YRDYSALKRQQLELLDQ 228
                  + +   R+QL+LL++
Sbjct: 2610 QEELLAEENQRLREQLQLLEE 2630



 Score = 35.4 bits (80), Expect = 0.10
 Identities = 29/117 (24%), Positives = 52/117 (44%), Gaps = 3/117 (2%)

Query: 134  ALTEADSQNYQRCLETGELATSEDEAAALRA-ELRDLELEEARLVQELEDVDRNNARAAA 192
            A  +A ++  ++  E      ++ E AALR  +  D E+E+ +  +  E   R  A+   
Sbjct: 2156 AQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHK--KFAEQTLRQKAQVEQ 2213

Query: 193  DLQAAQAEAAELDQQERQHYRDYSALKRQQLELLDQLGNVENQLQYARVQRDRLKEI 249
            +L   + +  E D Q+     +   LK +  E   Q   VE +L   RVQ + L ++
Sbjct: 2214 ELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKL 2270



 Score = 35.0 bits (79), Expect = 0.13
 Identities = 29/109 (26%), Positives = 52/109 (47%), Gaps = 1/109 (0%)

Query: 137  EADSQNYQRCLETGELATSEDEAAALRAELRDLELEEARLVQELEDVDRNNARAAADLQA 196
            E +    QR L   ELA  + EAAA   + ++LE E A++  E+E +  + ARA  + ++
Sbjct: 1748 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS 1807

Query: 197  AQAEAAELDQQERQHYRDYSALKRQQLELLDQLGNVENQLQYARVQRDR 245
               ++ +  + E   +R+  A +  +L  L +    + QL      R R
Sbjct: 1808 TSEKSKQRLEAEAGRFREL-AEEAARLRALAEEAKRQRQLAEEDAARQR 1855



 Score = 34.7 bits (78), Expect = 0.17
 Identities = 36/118 (30%), Positives = 51/118 (43%), Gaps = 5/118 (4%)

Query: 129  LDIQLALTEADSQ-NYQRCLETGELATSEDEAAALRAELRDLELEEARLVQELEDVDRNN 187
            L+ Q  L EA +Q   Q   E  EL     E    R E      ++ R +QE     R +
Sbjct: 1396 LEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQS 1455

Query: 188  ARAAADLQAAQAEAAELDQQERQHYRDYSALKRQQLELLD-QLGNVENQLQYARVQRD 244
            + A    +A QAEAAE   + R    +   + R QLE  + Q G  E +LQ  R + +
Sbjct: 1456 SEAEIQAKARQAEAAE---RSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAE 1510



 Score = 33.5 bits (75), Expect = 0.38
 Identities = 36/132 (27%), Positives = 67/132 (50%), Gaps = 17/132 (12%)

Query: 128  QLDIQLALTEADSQNYQRCLETGELA--TSEDEAAALRAELRDLELEEARLVQELEDVDR 185
            +L+ Q  L E D+   +R +E   LA   S ++AAA +AEL   ELE  R+    ED  R
Sbjct: 1932 ELERQKGLVE-DTLRQRRQVEEEILALKASFEKAAAGKAEL---ELELGRIRSNAEDTLR 1987

Query: 186  NNARAAADLQAAQAEAAELDQQERQHYRDYSALK---------RQQLELLDQLGNVENQL 236
              ++  A+L+AA+      +++ R+   +    K         RQ+   L+++  ++ ++
Sbjct: 1988 --SKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKV 2045

Query: 237  QYARVQRDRLKE 248
            + AR  R+R ++
Sbjct: 2046 EEARRLRERAEQ 2057



 Score = 29.6 bits (65), Expect = 5.5
 Identities = 31/119 (26%), Positives = 52/119 (43%), Gaps = 11/119 (9%)

Query: 135  LTEADSQNYQRCLETGELAT-----SEDEAAALRAELRDLELEEARLVQELEDVDRNNAR 189
            L E   Q   R L+  + A      +E++A A   + ++ EL++  L QE   +D+    
Sbjct: 2051 LRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT-LQQEQSVLDQLRGE 2109

Query: 190  AAADLQAAQAEAAELDQQERQHYRDYSALKRQQLELLDQLGNVENQLQYARVQRDRLKE 248
            A A  +AA+       Q ER+     +A  R+Q+E  ++L     +   AR Q     E
Sbjct: 2110 AEAARRAAEEAEEARVQAERE-----AAQSRRQVEEAERLKQSAEEQAQARAQAQAAAE 2163


>gi|190194355 p90 autoantigen [Homo sapiens]
          Length = 905

 Score = 38.1 bits (87), Expect = 0.016
 Identities = 35/154 (22%), Positives = 67/154 (43%), Gaps = 15/154 (9%)

Query: 108 SGQAVVDHPLCEECTDSLLEQLDIQLALTEADSQNYQRCLETGELATSEDE--AAALRAE 165
           SG  V D  +C+     +++  +++L+   +     Q  LET  LA ++ +   A  R +
Sbjct: 606 SGMVVKDQ-ICDVRISDIMDVYEMKLSTLASKESRLQDLLETKALALAQADRLIAQHRCQ 664

Query: 166 LRDLELEEARLVQELEDVDRNNARAAADLQAAQAEAAELDQQERQHY-----------RD 214
               E E   L   L +V+R N   +  L+A Q E +E  Q + +H             +
Sbjct: 665 RTQAETEARTLASMLREVERKNEELSVLLKAQQVE-SERAQSDIEHLFQHNRKLESVAEE 723

Query: 215 YSALKRQQLELLDQLGNVENQLQYARVQRDRLKE 248
           +  L +  +ELL +  + E + +  ++  D L +
Sbjct: 724 HEILTKSYMELLQRNESTEKKNKDLQITCDSLNK 757


>gi|194353964 coiled-coil domain containing 157 [Homo sapiens]
          Length = 752

 Score = 38.1 bits (87), Expect = 0.016
 Identities = 23/112 (20%), Positives = 48/112 (42%)

Query: 128 QLDIQLALTEADSQNYQRCLETGELATSEDEAAALRAELRDLELEEARLVQELEDVDRNN 187
           +  +QL +   +    Q C  + EL   +    ++      L+ ++  L+++L+ +D+  
Sbjct: 406 EAQVQLLVGRLEGAGQQVCWASTELDKEKARVDSMVRHQESLQAKQRALLKQLDSLDQER 465

Query: 188 ARAAADLQAAQAEAAELDQQERQHYRDYSALKRQQLELLDQLGNVENQLQYA 239
                 L  A+A+ A +++Q +          R Q ELL  L   +  L+ A
Sbjct: 466 EELRGSLDEAEAQRARVEEQLQSEREQGQCQLRAQQELLQSLQREKQGLEQA 517


>gi|56550043 sarcolemma associated protein [Homo sapiens]
          Length = 811

 Score = 38.1 bits (87), Expect = 0.016
 Identities = 23/79 (29%), Positives = 39/79 (49%)

Query: 157 DEAAALRAELRDLELEEARLVQELEDVDRNNARAAADLQAAQAEAAELDQQERQHYRDYS 216
           +EA  L+ EL  L  E   L  E   + R N   +++LQ  + E     +Q  +   D S
Sbjct: 633 EEATRLQGELEKLRKEWNALETECHSLKRENVLLSSELQRQEKELHNSQKQSLELTSDLS 692

Query: 217 ALKRQQLELLDQLGNVENQ 235
            L+  + EL +Q+G+++ Q
Sbjct: 693 ILQMSRKELENQVGSLKEQ 711



 Score = 33.5 bits (75), Expect = 0.38
 Identities = 30/120 (25%), Positives = 47/120 (39%), Gaps = 11/120 (9%)

Query: 139 DSQNYQRCLETGELATSEDEAAALRAELRDLELEEARLVQELE-------DVDRNNARAA 191
           D Q  +     GEL     E  AL  E   L+ E   L  EL+       +  + +    
Sbjct: 629 DQQREEATRLQGELEKLRKEWNALETECHSLKRENVLLSSELQRQEKELHNSQKQSLELT 688

Query: 192 ADLQAAQAEAAELDQQ----ERQHYRDYSALKRQQLELLDQLGNVENQLQYARVQRDRLK 247
           +DL   Q    EL+ Q    + QH RD + LK    +  +Q  +V+ + +  +     LK
Sbjct: 689 SDLSILQMSRKELENQVGSLKEQHLRDSADLKTLLSKAENQAKDVQKEYEKTQTVLSELK 748


>gi|122937382 Fas (TNFRSF6) binding factor 1 [Homo sapiens]
          Length = 1133

 Score = 37.7 bits (86), Expect = 0.020
 Identities = 30/117 (25%), Positives = 53/117 (45%), Gaps = 18/117 (15%)

Query: 127  EQLDIQLALTEADSQNYQRCLETGELATSEDE---------AAALRAELRDLELEEARLV 177
            EQ ++++  +E  ++  Q   E   L     E         A ALR +LR  E+E    V
Sbjct: 924  EQAELKIRASELRAEEKQLAAERAALEQERQELRLEKERINATALRVKLRAEEVESMSKV 983

Query: 178  ---------QELEDVDRNNARAAADLQAAQAEAAELDQQERQHYRDYSALKRQQLEL 225
                     + L +  +  A   A LQA Q +   L +QE+  ++++ +L +Q+L+L
Sbjct: 984  ASEKYEEGERALREAQQVQAEQQARLQAVQQQQERLRKQEQHMHQEHLSLAQQRLQL 1040



 Score = 35.4 bits (80), Expect = 0.10
 Identities = 33/122 (27%), Positives = 54/122 (44%), Gaps = 12/122 (9%)

Query: 124 SLLEQLDIQLALTEADSQNYQRCLETGELATSEDEAAALRAELRDLELEEARLVQELEDV 183
           SL +Q    L L E+  ++  + LET      E     LR E  +L    AR + + ++ 
Sbjct: 612 SLQQQHQADLELIESAHRSRIKVLETSYQQREE----RLRRENEELS---ARYLSQCQEA 664

Query: 184 DRNNARAAADLQAAQAEAAELDQQERQHYRDYSALKRQQLELLDQLGNVENQLQYARVQR 243
           ++  A   A  Q   A  A+   QE +  R+      Q+  +LD   + E QLQ  ++ +
Sbjct: 665 EQARAELTAQHQRRLAAIAQEKDQEMERLREL-----QRASILDMRRDHEEQLQRLKLLK 719

Query: 244 DR 245
           DR
Sbjct: 720 DR 721


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.133    0.388 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,596,080
Number of Sequences: 37866
Number of extensions: 693236
Number of successful extensions: 5381
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 83
Number of HSP's successfully gapped in prelim test: 269
Number of HSP's that attempted gapping in prelim test: 4487
Number of HSP's gapped (non-prelim): 1108
length of query: 431
length of database: 18,247,518
effective HSP length: 105
effective length of query: 326
effective length of database: 14,271,588
effective search space: 4652537688
effective search space used: 4652537688
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 63 (28.9 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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