BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|239752495 PREDICTED: similar to nebulin [Homo sapiens] (237 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|239752495 PREDICTED: similar to nebulin [Homo sapiens] 493 e-140 gi|169217576 PREDICTED: similar to nebulin [Homo sapiens] 357 7e-99 gi|115527120 nebulin [Homo sapiens] 253 8e-68 gi|46049092 nebulin-related anchoring protein isoform C [Homo sa... 159 3e-39 gi|46049105 nebulin-related anchoring protein isoform S [Homo sa... 159 3e-39 gi|5453758 nebulette sarcomeric isoform [Homo sapiens] 62 3e-10 gi|47087157 nebulette non-muscle isoform [Homo sapiens] 37 0.011 gi|5453710 LIM and SH3 protein 1 [Homo sapiens] 37 0.019 gi|127138957 zinc finger protein 537 [Homo sapiens] 30 1.4 gi|222352158 carboxypeptidase 3, cytosolic [Homo sapiens] 30 2.4 gi|68299795 chromodomain helicase DNA binding protein 1 [Homo sa... 30 2.4 gi|110349721 titin isoform novex-3 [Homo sapiens] 29 4.1 gi|110349719 titin isoform N2-A [Homo sapiens] 29 4.1 gi|110349717 titin isoform novex-2 [Homo sapiens] 29 4.1 gi|110349713 titin isoform novex-1 [Homo sapiens] 29 4.1 gi|110349715 titin isoform N2-B [Homo sapiens] 29 4.1 gi|239741279 PREDICTED: similar to FLJ00310 protein [Homo sapiens] 28 5.3 gi|26080431 ATPase family, AAA domain containing 5 [Homo sapiens] 28 5.3 gi|45446749 kinesin family member 5A [Homo sapiens] 28 5.3 gi|87298937 centrosomal protein 110kDa [Homo sapiens] 28 5.3 gi|19923424 myotubularin related protein 9 [Homo sapiens] 28 9.0 gi|112380630 leiomodin 1 (smooth muscle) [Homo sapiens] 28 9.0 >gi|239752495 PREDICTED: similar to nebulin [Homo sapiens] Length = 237 Score = 493 bits (1269), Expect = e-140 Identities = 237/237 (100%), Positives = 237/237 (100%) Query: 1 MHLSCLFPKPHTYDLSLPEVPSYKYKEGYRKQLGHHMGFRTLQDDPKSVWAIHAAKIQSD 60 MHLSCLFPKPHTYDLSLPEVPSYKYKEGYRKQLGHHMGFRTLQDDPKSVWAIHAAKIQSD Sbjct: 1 MHLSCLFPKPHTYDLSLPEVPSYKYKEGYRKQLGHHMGFRTLQDDPKSVWAIHAAKIQSD 60 Query: 61 REYKKAYEKSKGIHNTPLDMMSIVQAKKCQVLVSDIDYRNYLHQWTCLPDQNDVIQAKKA 120 REYKKAYEKSKGIHNTPLDMMSIVQAKKCQVLVSDIDYRNYLHQWTCLPDQNDVIQAKKA Sbjct: 61 REYKKAYEKSKGIHNTPLDMMSIVQAKKCQVLVSDIDYRNYLHQWTCLPDQNDVIQAKKA 120 Query: 121 YDLQSDNLYKSDLEWLKGIGWLPEGSVEVMRVKNAQNLLNERLYRIKPEALKFTSIVDTP 180 YDLQSDNLYKSDLEWLKGIGWLPEGSVEVMRVKNAQNLLNERLYRIKPEALKFTSIVDTP Sbjct: 121 YDLQSDNLYKSDLEWLKGIGWLPEGSVEVMRVKNAQNLLNERLYRIKPEALKFTSIVDTP 180 Query: 181 EVIQAKINAVQISEVEKSRDNFNVRHYGSYLDQKQLGPAQQWELSELSAMWTYPSDN 237 EVIQAKINAVQISEVEKSRDNFNVRHYGSYLDQKQLGPAQQWELSELSAMWTYPSDN Sbjct: 181 EVIQAKINAVQISEVEKSRDNFNVRHYGSYLDQKQLGPAQQWELSELSAMWTYPSDN 237 >gi|169217576 PREDICTED: similar to nebulin [Homo sapiens] Length = 410 Score = 357 bits (915), Expect = 7e-99 Identities = 177/188 (94%), Positives = 178/188 (94%), Gaps = 6/188 (3%) Query: 23 YKYKEGYRKQLGHHMGFRTLQDDPKSVWAIHAAKIQSDREYKKAYEKSKGIHNTPLDMMS 82 YKYKEGYRKQLGHHMGFRTLQDDPKSVWAIHAAKIQSDREYKKAYEKSKGIHNTPLDMMS Sbjct: 50 YKYKEGYRKQLGHHMGFRTLQDDPKSVWAIHAAKIQSDREYKKAYEKSKGIHNTPLDMMS 109 Query: 83 IVQAKKCQVLVSDIDYRNYLHQWTCLPDQNDVIQAKKAYDLQSDNLYKSDLEWLKGIGWL 142 IVQAKKCQVLVSDIDYRNYLHQWTCLPDQNDVIQAKKAYDLQSDNLYKSDLEWLKGIGWL Sbjct: 110 IVQAKKCQVLVSDIDYRNYLHQWTCLPDQNDVIQAKKAYDLQSDNLYKSDLEWLKGIGWL 169 Query: 143 PEGSVEVMRVKNAQNLLNERLYRIKPEALKFTSIVDTPEVIQAKINAVQISEV------E 196 PEGSVEVMRVKNAQNLLNERLYRIKPEALKFTSIVDTPEVIQAKINAVQISE E Sbjct: 170 PEGSVEVMRVKNAQNLLNERLYRIKPEALKFTSIVDTPEVIQAKINAVQISEPLYRNAWE 229 Query: 197 KSRDNFNV 204 K + N NV Sbjct: 230 KEKANVNV 237 Score = 136 bits (342), Expect = 2e-32 Identities = 62/104 (59%), Positives = 78/104 (75%) Query: 23 YKYKEGYRKQLGHHMGFRTLQDDPKSVWAIHAAKIQSDREYKKAYEKSKGIHNTPLDMMS 82 Y YK Y KQ GH++G R+ ++DPK VWA + K+Q+DR YKKAY K + P+DM+S Sbjct: 293 YLYKTAYEKQKGHYIGCRSAKEDPKLVWAANVLKMQNDRLYKKAYNDHKAKISIPVDMVS 352 Query: 83 IVQAKKCQVLVSDIDYRNYLHQWTCLPDQNDVIQAKKAYDLQSD 126 I AK+ Q L SD+DYR+YLH W+C PDQNDVIQA+KAYDLQSD Sbjct: 353 ISAAKEGQALASDVDYRHYLHHWSCFPDQNDVIQARKAYDLQSD 396 Score = 45.4 bits (106), Expect = 4e-05 Identities = 50/194 (25%), Positives = 89/194 (45%), Gaps = 15/194 (7%) Query: 39 FRTLQDDPKSVWA-IHAAKIQSDREYKKAYEKSKGIHNTPLDMMSIVQAKKCQVLVSDID 97 F ++ D P+ + A I+A +I S+ Y+ A+EK K N P D ++Q+K + +S+ Sbjct: 200 FTSIVDTPEVIQAKINAVQI-SEPLYRNAWEKEKANVNVPADTPLMLQSKINALQISNKR 258 Query: 98 YRN-----YLHQWTCLPDQNDVIQAKKAYDLQSDNLYKSDLEWLKG--IGW-LPEGSVEV 149 Y+ + + D + AK + D+ SD LYK+ E KG IG + ++ Sbjct: 259 YQQAWEDVKMTGYDLRADAIGIQHAKASRDIASDYLYKTAYEKQKGHYIGCRSAKEDPKL 318 Query: 150 MRVKNAQNLLNERLYR--IKPEALKFTSIVDTPEVIQAKINAVQISEVEKSRDNFNVRHY 207 + N + N+RLY+ K + VD + AK S+V+ + H+ Sbjct: 319 VWAANVLKMQNDRLYKKAYNDHKAKISIPVDMVSISAAKEGQALASDVDY---RHYLHHW 375 Query: 208 GSYLDQKQLGPAQQ 221 + DQ + A++ Sbjct: 376 SCFPDQNDVIQARK 389 >gi|115527120 nebulin [Homo sapiens] Length = 6669 Score = 253 bits (647), Expect = 8e-68 Identities = 121/198 (61%), Positives = 151/198 (76%), Gaps = 12/198 (6%) Query: 9 KPHTYDLSLPEVP------------SYKYKEGYRKQLGHHMGFRTLQDDPKSVWAIHAAK 56 K YDL L +P YKYKEGYRKQLGHH+G R ++DDPK +W+IH AK Sbjct: 3495 KKEGYDLRLDAIPIQAAKASRDIASDYKYKEGYRKQLGHHIGARNIKDDPKMMWSIHVAK 3554 Query: 57 IQSDREYKKAYEKSKGIHNTPLDMMSIVQAKKCQVLVSDIDYRNYLHQWTCLPDQNDVIQ 116 IQSDREYKK +EK K ++P+DM+ +V AKKCQ+LVSDIDY++ LH+WTCLPDQNDVIQ Sbjct: 3555 IQSDREYKKEFEKWKTKFSSPVDMLGVVLAKKCQILVSDIDYKHPLHEWTCLPDQNDVIQ 3614 Query: 117 AKKAYDLQSDNLYKSDLEWLKGIGWLPEGSVEVMRVKNAQNLLNERLYRIKPEALKFTSI 176 A+KAYDLQSD +YKSDLEWL+GIGW+P GSVEV +VK A +L++R YR + LKFT I Sbjct: 3615 ARKAYDLQSDAIYKSDLEWLRGIGWVPIGSVEVEKVKRAGEILSDRKYRQPADQLKFTCI 3674 Query: 177 VDTPEVIQAKINAVQISE 194 DTPE++ AK NA+ +S+ Sbjct: 3675 TDTPEIVLAKNNALTMSK 3692 Score = 249 bits (635), Expect = 2e-66 Identities = 115/171 (67%), Positives = 143/171 (83%) Query: 23 YKYKEGYRKQLGHHMGFRTLQDDPKSVWAIHAAKIQSDREYKKAYEKSKGIHNTPLDMMS 82 YKYKE Y KQ GHH+G ++++DDPK + AIHA KIQS+REYKK ++K K ++P+DM+S Sbjct: 3764 YKYKEAYEKQKGHHIGAQSIEDDPKIMCAIHAGKIQSEREYKKEFQKWKTKFSSPVDMLS 3823 Query: 83 IVQAKKCQVLVSDIDYRNYLHQWTCLPDQNDVIQAKKAYDLQSDNLYKSDLEWLKGIGWL 142 I+ AKKCQ LV+DIDYRNYLH+WTC+PDQND+IQAKKAYDLQSD LYK+DLEWL+GIGW+ Sbjct: 3824 ILLAKKCQTLVTDIDYRNYLHEWTCMPDQNDIIQAKKAYDLQSDALYKADLEWLRGIGWM 3883 Query: 143 PEGSVEVMRVKNAQNLLNERLYRIKPEALKFTSIVDTPEVIQAKINAVQIS 193 P+GS EV+RVKNAQN+ + +YR LK+TSIVDTPEV+ AK NA IS Sbjct: 3884 PQGSPEVLRVKNAQNIFCDSVYRTPVVNLKYTSIVDTPEVVLAKSNAENIS 3934 Score = 248 bits (632), Expect = 4e-66 Identities = 116/198 (58%), Positives = 148/198 (74%), Gaps = 12/198 (6%) Query: 9 KPHTYDLSLPEVP------------SYKYKEGYRKQLGHHMGFRTLQDDPKSVWAIHAAK 56 K YDL +P YKYKE YRKQLGHH+G R + DDPK +W++H AK Sbjct: 3252 KKEGYDLRSDAIPIVAAKASRDIASDYKYKEAYRKQLGHHIGARAVHDDPKIMWSLHIAK 3311 Query: 57 IQSDREYKKAYEKSKGIHNTPLDMMSIVQAKKCQVLVSDIDYRNYLHQWTCLPDQNDVIQ 116 +QSDREYKK +EK K +++P+DM+ IV AKKCQ LVSD+DY++ LH+W CLPDQND+I Sbjct: 3312 VQSDREYKKDFEKYKTRYSSPVDMLGIVLAKKCQTLVSDVDYKHPLHEWICLPDQNDIIH 3371 Query: 117 AKKAYDLQSDNLYKSDLEWLKGIGWLPEGSVEVMRVKNAQNLLNERLYRIKPEALKFTSI 176 A+KAYDLQSDNLYKSDLEW+KGIGW+P S+EV+R K A LL++ +YR +PE LKFTSI Sbjct: 3372 ARKAYDLQSDNLYKSDLEWMKGIGWVPIDSLEVVRAKRAGELLSDTIYRQRPETLKFTSI 3431 Query: 177 VDTPEVIQAKINAVQISE 194 DTPE + AK NA+ +++ Sbjct: 3432 TDTPEQVLAKNNALNMNK 3449 Score = 245 bits (626), Expect = 2e-65 Identities = 106/175 (60%), Positives = 145/175 (82%) Query: 20 VPSYKYKEGYRKQLGHHMGFRTLQDDPKSVWAIHAAKIQSDREYKKAYEKSKGIHNTPLD 79 + YKYK+GYRKQLGHH+G R ++DDPK +W++H AKIQSDREYKK +EK K ++P+D Sbjct: 3032 ISDYKYKDGYRKQLGHHIGARNIEDDPKMMWSMHVAKIQSDREYKKDFEKWKTKFSSPVD 3091 Query: 80 MMSIVQAKKCQVLVSDIDYRNYLHQWTCLPDQNDVIQAKKAYDLQSDNLYKSDLEWLKGI 139 M+ +V AKKCQ LVSD+DY+NYLH+WTCLPDQNDVI A++AYDLQSDN+YKSDL+WL+GI Sbjct: 3092 MLGVVLAKKCQTLVSDVDYKNYLHEWTCLPDQNDVIHARQAYDLQSDNIYKSDLQWLRGI 3151 Query: 140 GWLPEGSVEVMRVKNAQNLLNERLYRIKPEALKFTSIVDTPEVIQAKINAVQISE 194 GW+P GS++V++ K A +L++ +YR P+ LKFTS+ D+ E + AK NA+ +++ Sbjct: 3152 GWVPIGSMDVVKCKRAAEILSDNIYRQPPDKLKFTSVTDSLEQVLAKNNALNMNK 3206 Score = 237 bits (605), Expect = 6e-63 Identities = 103/172 (59%), Positives = 142/172 (82%) Query: 23 YKYKEGYRKQLGHHMGFRTLQDDPKSVWAIHAAKIQSDREYKKAYEKSKGIHNTPLDMMS 82 +KYKEGYRKQLGHH+G R ++DDPK +W++H AKIQSDREYKK +EK K ++P+DM+ Sbjct: 2792 FKYKEGYRKQLGHHIGARAIRDDPKMMWSMHVAKIQSDREYKKDFEKWKTKFSSPVDMLG 2851 Query: 83 IVQAKKCQVLVSDIDYRNYLHQWTCLPDQNDVIQAKKAYDLQSDNLYKSDLEWLKGIGWL 142 +V AKKCQ LVSD+DY+NYLHQWTCLPDQ+DVI A++AYDLQSDN+YKSDL+W++GIGW+ Sbjct: 2852 VVLAKKCQTLVSDVDYKNYLHQWTCLPDQSDVIHARQAYDLQSDNMYKSDLQWMRGIGWV 2911 Query: 143 PEGSVEVMRVKNAQNLLNERLYRIKPEALKFTSIVDTPEVIQAKINAVQISE 194 GS++V + K A +L++++YR P+ KFTS+ D+ E + AK NA+ +++ Sbjct: 2912 SIGSLDVEKCKRATEILSDKIYRQPPDRFKFTSVTDSLEQVLAKNNALNMNK 2963 Score = 236 bits (603), Expect = 1e-62 Identities = 108/193 (55%), Positives = 146/193 (75%), Gaps = 12/193 (6%) Query: 13 YDLSLPEVP------------SYKYKEGYRKQLGHHMGFRTLQDDPKSVWAIHAAKIQSD 60 YDL + +P YKYKEG+RKQLGHH+G R ++DDPK +W++H AKIQSD Sbjct: 2527 YDLPVDAIPIKAAKASREIASEYKYKEGFRKQLGHHIGARNIEDDPKMMWSMHVAKIQSD 2586 Query: 61 REYKKAYEKSKGIHNTPLDMMSIVQAKKCQVLVSDIDYRNYLHQWTCLPDQNDVIQAKKA 120 REYKK +EK K ++P+DM+ +V AKKCQ LVSD+DY+NYLHQWTCLPDQ+DVI A++A Sbjct: 2587 REYKKDFEKWKTKFSSPVDMLGVVLAKKCQTLVSDVDYKNYLHQWTCLPDQSDVIHARQA 2646 Query: 121 YDLQSDNLYKSDLEWLKGIGWLPEGSVEVMRVKNAQNLLNERLYRIKPEALKFTSIVDTP 180 YDLQSDNLYKSDL+WLKGIGW+ GS+E + K A +L++ +YR P+ KF+S++D+ Sbjct: 2647 YDLQSDNLYKSDLQWLKGIGWMTSGSLEDEKNKRATQILSDHVYRQHPDQFKFSSLMDSI 2706 Query: 181 EVIQAKINAVQIS 193 ++ AK NA+ ++ Sbjct: 2707 PMVLAKNNAITMN 2719 Score = 236 bits (602), Expect = 1e-62 Identities = 108/172 (62%), Positives = 139/172 (80%) Query: 23 YKYKEGYRKQLGHHMGFRTLQDDPKSVWAIHAAKIQSDREYKKAYEKSKGIHNTPLDMMS 82 YKYK+GYRKQLGHH+GFR+LQDDPK V +++ AK+QS+REYKK +EK K ++P+DM+ Sbjct: 2306 YKYKQGYRKQLGHHVGFRSLQDDPKLVLSMNVAKMQSEREYKKDFEKWKTKFSSPVDMLG 2365 Query: 83 IVQAKKCQVLVSDIDYRNYLHQWTCLPDQNDVIQAKKAYDLQSDNLYKSDLEWLKGIGWL 142 +V AKKCQ LVSD+DY+NYLHQWTCLPDQNDV+QAKK Y+LQS+NLYKSDLEWL+GIGW Sbjct: 2366 VVLAKKCQELVSDVDYKNYLHQWTCLPDQNDVVQAKKVYELQSENLYKSDLEWLRGIGWS 2425 Query: 143 PEGSVEVMRVKNAQNLLNERLYRIKPEALKFTSIVDTPEVIQAKINAVQISE 194 P GS+E + K A +++E+ YR P+ KFTSI D +++ AK NA S+ Sbjct: 2426 PLGSLEAEKNKRASEIISEKKYRQPPDRNKFTSIPDAMDIVLAKTNAKNRSD 2477 Score = 204 bits (518), Expect = 7e-53 Identities = 102/184 (55%), Positives = 136/184 (73%), Gaps = 7/184 (3%) Query: 24 KYKEGYRKQLGHHMGFRTLQDDPKSVWAIHAAKIQSDREYKKAYEKSKGIHNTPLDMMSI 83 KYK + KQ GH++G T++DDPK VW HA +IQ++R YK+ Y K+K N P DM+S+ Sbjct: 4249 KYKAEHVKQKGHYVGVPTMRDDPKLVWFEHAGQIQNERLYKEDYHKTKAKINIPADMVSV 4308 Query: 84 VQAKKCQVLVSDIDYRNYLHQWTCLPDQNDVIQAKKAYDLQSDNLYKSDLEWLKGIGWLP 143 + AK+ Q LVSDIDYRNYLHQW C PDQNDVIQA+KAYDLQSDN+Y++DLEWL+GIGW+P Sbjct: 4309 LAAKQGQTLVSDIDYRNYLHQWMCHPDQNDVIQARKAYDLQSDNVYRADLEWLRGIGWIP 4368 Query: 144 EGSVEVMRVKNAQNLLNERLYRIKPEALK----FTSIVDTPEVIQAKINAVQISEVEKSR 199 SV+ +RV Q ++++ Y K AL+ F S+VD PE++ AKIN+V S+V K + Sbjct: 4369 LDSVDHVRVTKNQEMMSQIKY--KKNALENYPNFRSVVDPPEIVLAKINSVNQSDV-KYK 4425 Query: 200 DNFN 203 + FN Sbjct: 4426 ETFN 4429 Score = 198 bits (504), Expect = 3e-51 Identities = 92/178 (51%), Positives = 128/178 (71%) Query: 23 YKYKEGYRKQLGHHMGFRTLQDDPKSVWAIHAAKIQSDREYKKAYEKSKGIHNTPLDMMS 82 YKYK + KQ GH++G T +DD K WA+ A K+Q++REY+ + K K +P+DM+S Sbjct: 4006 YKYKLDHEKQKGHYVGTLTARDDNKIRWALIADKLQNEREYRLDWAKWKAKIQSPVDMLS 4065 Query: 83 IVQAKKCQVLVSDIDYRNYLHQWTCLPDQNDVIQAKKAYDLQSDNLYKSDLEWLKGIGWL 142 I+ +K Q LVSD+DYRNYLHQWTC+PDQNDVIQAKKAY+LQSDN+YK+DLEWL+GIGW+ Sbjct: 4066 ILHSKNSQALVSDMDYRNYLHQWTCMPDQNDVIQAKKAYELQSDNVYKADLEWLRGIGWM 4125 Query: 143 PEGSVEVMRVKNAQNLLNERLYRIKPEALKFTSIVDTPEVIQAKINAVQISEVEKSRD 200 P SV V K+A ++ +E+ YR K E L FT + D + + AK + + +++ +D Sbjct: 4126 PNDSVSVNHAKHAADIFSEKKYRTKIETLNFTPVDDRVDYVTAKQSGEILDDIKYRKD 4183 Score = 189 bits (481), Expect = 1e-48 Identities = 93/184 (50%), Positives = 131/184 (71%), Gaps = 1/184 (0%) Query: 24 KYKEGYRKQLGHHMGFRTLQDDPKSVWAIHAAKIQSDREYKKAYEKSKGIHNTPLDMMSI 83 +YK+ Y K G +GF++LQDDPK V ++ AKIQSDREYKK YEK+K +NTP DM ++ Sbjct: 1087 QYKKDYEKAKGKMVGFQSLQDDPKLVHYMNVAKIQSDREYKKDYEKTKSKYNTPHDMFNV 1146 Query: 84 VQAKKCQVLVSDIDYRNYLHQWTCLPDQNDVIQAKKAYDLQSDNLYKSDL-EWLKGIGWL 142 V AKK Q +VS+++Y++ LH +T LPD D+ +K +QSDN+YK D W+KGIGW+ Sbjct: 1147 VAAKKAQDVVSNVNYKHSLHHYTYLPDAMDLELSKNMMQIQSDNVYKEDYNNWMKGIGWI 1206 Query: 143 PEGSVEVMRVKNAQNLLNERLYRIKPEALKFTSIVDTPEVIQAKINAVQISEVEKSRDNF 202 P GS++V +VK A + LNE+ YR P+ LKFTSIVD+P ++QAK N Q+S++ Sbjct: 1207 PIGSLDVEKVKKAGDALNEKKYRQHPDTLKFTSIVDSPVMVQAKQNTKQVSDILYKAKGE 1266 Query: 203 NVRH 206 +V+H Sbjct: 1267 DVKH 1270 Score = 176 bits (446), Expect = 2e-44 Identities = 86/172 (50%), Positives = 118/172 (68%), Gaps = 1/172 (0%) Query: 25 YKEGYRKQLGHHMGFRTLQDDPKSVWAIHAAKIQSDREYKKAYEKSKGIHNTPLDMMSIV 84 YK+ Y K G +G ++ DDPK + ++ AK QSDREY+K YEKSK I+ PLDM+ + Sbjct: 844 YKKDYEKSKGKMIGALSINDDPKMLHSLKTAKNQSDREYRKDYEKSKTIYTAPLDMLQVT 903 Query: 85 QAKKCQVLVSDIDYRNYLHQWTCLPDQNDVIQAKKAYDLQSDNLYKSDL-EWLKGIGWLP 143 QAKK Q + SD+DY++ LH ++ PD +V AKKAY LQSD YK+D W+KG GW+P Sbjct: 904 QAKKSQAIASDVDYKHILHSYSYPPDSINVDLAKKAYALQSDVEYKADYNSWMKGCGWVP 963 Query: 144 EGSVEVMRVKNAQNLLNERLYRIKPEALKFTSIVDTPEVIQAKINAVQISEV 195 GS+E+ + K A ++LNE+ YR P+ LKFTSI D P +Q+KIN Q S++ Sbjct: 964 FGSLEMEKAKRASDILNEKKYRQHPDTLKFTSIEDAPITVQSKINQAQRSDI 1015 Score = 172 bits (437), Expect = 2e-43 Identities = 85/185 (45%), Positives = 124/185 (67%), Gaps = 1/185 (0%) Query: 23 YKYKEGYRKQLGHHMGFRTLQDDPKSVWAIHAAKIQSDREYKKAYEKSKGIHNTPLDMMS 82 YKYKE Y K G H+GFR+LQDDPK V ++ AK+QSDREYKK YE +K ++TP DM+S Sbjct: 1330 YKYKEAYEKSKGKHVGFRSLQDDPKLVHYMNVAKLQSDREYKKNYENTKTSYHTPGDMVS 1389 Query: 83 IVQAKKCQVLVSDIDYRNYLHQWTCLPDQNDVIQAKKAYDLQSDNLYKSDL-EWLKGIGW 141 I AK Q + ++++Y+ LH +T LPD + + +QSDN+YK + +LKGIGW Sbjct: 1390 ITAAKMAQDVATNVNYKQPLHHYTYLPDAMSLEHTRNVNQIQSDNVYKDEYNSFLKGIGW 1449 Query: 142 LPEGSVEVMRVKNAQNLLNERLYRIKPEALKFTSIVDTPEVIQAKINAVQISEVEKSRDN 201 +P GS+EV +VK A + LNER YR P+ +KFTS+ D+ ++ A+ N Q+S++ + Sbjct: 1450 IPIGSLEVEKVKKAGDALNERKYRQHPDTVKFTSVPDSMGMVLAQHNTKQLSDLNYKVEG 1509 Query: 202 FNVRH 206 ++H Sbjct: 1510 EKLKH 1514 Score = 167 bits (424), Expect = 6e-42 Identities = 86/172 (50%), Positives = 114/172 (66%), Gaps = 1/172 (0%) Query: 24 KYKEGYRKQLGHHMGFRTLQDDPKSVWAIHAAKIQSDREYKKAYEKSKGIHNTPLDMMSI 83 KYKE Y K G +GF +LQDDPK V ++ AKIQSDREYKK YE SK ++TPLDM+S+ Sbjct: 1575 KYKEAYEKAKGKQVGFLSLQDDPKLVHYMNVAKIQSDREYKKGYEASKTKYHTPLDMVSV 1634 Query: 84 VQAKKCQVLVSDIDYRNYLHQWTCLPDQNDVIQAKKAYDLQSDNLYKSDL-EWLKGIGWL 142 AKK Q + ++ +YR H +T LPD +V ++ A +QSDNLYKSD W+KGIGW+ Sbjct: 1635 TAAKKSQEVATNANYRQSYHHYTLLPDALNVEHSRNAMQIQSDNLYKSDFTNWMKGIGWV 1694 Query: 143 PEGSVEVMRVKNAQNLLNERLYRIKPEALKFTSIVDTPEVIQAKINAVQISE 194 P S+EV + K A +L+E+ YR PE LKFT +DT E K N + + + Sbjct: 1695 PIESLEVEKAKKAGEILSEKKYRQHPEKLKFTYAMDTMEQALNKSNKLNMDK 1746 Score = 166 bits (421), Expect = 1e-41 Identities = 80/173 (46%), Positives = 120/173 (69%), Gaps = 1/173 (0%) Query: 23 YKYKEGYRKQLGHHMGFRTLQDDPKSVWAIHAAKIQSDREYKKAYEKSKGIHNTPLDMMS 82 YKYK+ Y + G H+GFR+L+DDPK V + AK+QSDREYKK YEKSK +TP+DM+S Sbjct: 1818 YKYKKAYEQAKGKHIGFRSLEDDPKLVHFMQVAKMQSDREYKKGYEKSKTSFHTPVDMLS 1877 Query: 83 IVQAKKCQVLVSDIDYRNYLHQWTCLPDQNDVIQAKKAYDLQSDNLYKSD-LEWLKGIGW 141 +V AKK Q + ++ +YRN +H + LPD AK +QSDN YK+D +++KGIGW Sbjct: 1878 VVAAKKSQEVATNANYRNVIHTYNMLPDAMSFELAKNMMQIQSDNQYKADYADFMKGIGW 1937 Query: 142 LPEGSVEVMRVKNAQNLLNERLYRIKPEALKFTSIVDTPEVIQAKINAVQISE 194 LP GS+E + K A +++E+ YR P+ LK+++++D+ ++ A+ NA ++E Sbjct: 1938 LPLGSLEAEKNKKAMEIISEKKYRQHPDTLKYSTLMDSMNMVLAQNNAKIMNE 1990 Score = 148 bits (374), Expect = 4e-36 Identities = 71/168 (42%), Positives = 107/168 (63%), Gaps = 1/168 (0%) Query: 23 YKYKEGYRKQLGHHMGFRTLQDDPKSVWAIHAAKIQSDREYKKAYEKSKGIHNTPLDMMS 82 YKYK Y K G +GFR+L+DDPK V ++ AK+QSDREYKK YE +K ++TP DM+S Sbjct: 2062 YKYKYNYEKGKGKMVGFRSLEDDPKLVHSMQVAKMQSDREYKKNYENTKTSYHTPADMLS 2121 Query: 83 IVQAKKCQVLVSDIDYRNYLHQWTCLPDQNDVIQAKKAYDLQSDNLYKSDL-EWLKGIGW 141 + AK Q +++ +Y++ +H++ LPD ++ + +QSDN YK D EW KG+GW Sbjct: 2122 VTAAKDAQANITNTNYKHLIHKYILLPDAMNIELTRNMNRIQSDNEYKQDYNEWYKGLGW 2181 Query: 142 LPEGSVEVMRVKNAQNLLNERLYRIKPEALKFTSIVDTPEVIQAKINA 189 P GS+EV + K A +++ YR P +F + D+ +++ AK NA Sbjct: 2182 SPAGSLEVEKAKKATEYASDQKYRQHPSNFQFKKLTDSMDMVLAKQNA 2229 Score = 129 bits (325), Expect = 2e-30 Identities = 66/182 (36%), Positives = 109/182 (59%), Gaps = 3/182 (1%) Query: 24 KYKEGYRKQLGHHMGFRTLQDDPKSVWAIHAAKIQSDREYKKAYEKSKGIHNTPLDMMSI 83 KYKE Y KQ GH++ + + + P V + K++S Y+K YE +K + P DMM+ Sbjct: 4494 KYKETYEKQKGHYLAGKVIGEFPGVVHCLDFQKMRSALNYRKHYEDTKANVHIPNDMMNH 4553 Query: 84 VQAKKCQVLVSDIDYRNYLHQWTCLPDQNDVIQAKKAYDLQSDNLYKSDLEWLKGIGWLP 143 V AK+CQ ++SD++YR+Y HQWT L ++ +VI+ + A ++ SDN+YK DL WLKGIG Sbjct: 4554 VLAKRCQYILSDLEYRHYFHQWTSLLEEPNVIRVRNAQEILSDNVYKDDLNWLKGIGCYV 4613 Query: 144 EGSVEVMRVKNAQNLLNERLYRI--KPEALKFTSIVDTPEVIQAKINAVQISEVEKSRDN 201 + +++ K + +L ++ Y K + + DTP + A + + SEV K ++N Sbjct: 4614 WDTPQILHAKKSYDLQSQLQYTAAGKENLQNYNLVTDTPLYVTAVQSGINASEV-KYKEN 4672 Query: 202 FN 203 ++ Sbjct: 4673 YH 4674 Score = 107 bits (268), Expect = 7e-24 Identities = 67/176 (38%), Positives = 95/176 (53%), Gaps = 8/176 (4%) Query: 24 KYKEGYRKQLGHHMGFRTLQDDPKSVWAIHAAKIQSDREYKKAYEKSK-GIHNTPLDMMS 82 KY+E Y K + R++ DDP + + K+ DR Y+ YEK+K IH P DM+ Sbjct: 4739 KYREEYEKFKALYTLPRSVDDDPNTARCLRVGKLNIDRLYRSVYEKNKMKIHIVP-DMVE 4797 Query: 83 IVQAKKCQVLVSDIDYRNYLHQWTCLPDQNDVIQAKKAYDLQSDNLYKSDLEWLKGIGWL 142 +V AK Q VS+IDYR LH+W C PD +K D SD +YK DL WLKGIG Sbjct: 4798 MVTAKDSQKKVSEIDYRLRLHEWICHPDLQVNDHVRKVTDQISDIVYKDDLNWLKGIGCY 4857 Query: 143 PEGSVEVMRVKNAQNLLNERLYRIKPEALK----FTSIVDTPEVIQAKINAVQISE 194 + E++ K+A +L ++ Y K LK + + DTP +QA + Q+S+ Sbjct: 4858 VWDTPEILHAKHAYDLRDDIKY--KAHMLKTRNDYKLVTDTPVYVQAVKSGKQLSD 4911 Score = 81.6 bits (200), Expect = 5e-16 Identities = 50/188 (26%), Positives = 88/188 (46%), Gaps = 9/188 (4%) Query: 25 YKEGYRKQLGHHMGFRTLQDDPKSVWAIHAAKIQSDREYKKAYEKSK----GIHNTPLDM 80 YK+ Y K G +G ++ DDPK + ++ AK QSDR YK+ YEK+K TP Sbjct: 597 YKKDYEKNKGKMIGVLSINDDPKMLHSLKVAKNQSDRLYKENYEKTKAKSMNYCETPKYQ 656 Query: 81 MSIVQAKKCQVLVSDIDYRNYLHQWTCLPDQNDVIQAKKAYDLQSDNLYKSDLEWLKGIG 140 + + D+ ++ L + + K SD YK++ E KG Sbjct: 657 LDTQLKNFSEARYKDLYVKDVLGHYVGSMEDPYHTHCMKVAAQNSDKSYKAEYEEDKGKC 716 Query: 141 WLPEGSVEVMRVKNAQNLLNERLYRIKPEALKFTSIVDTPEVIQAKINAVQISEVEKSRD 200 + P+ + + + Y++ P+ KFT++ D+P ++QA++N Q+S++ Sbjct: 717 YFPQTITQEYEAIKKLDQCKDHTYKVHPDKTKFTAVTDSPVLLQAQLNTKQLSDL----- 771 Query: 201 NFNVRHYG 208 N+ +H G Sbjct: 772 NYKAKHEG 779 Score = 73.2 bits (178), Expect = 2e-13 Identities = 58/185 (31%), Positives = 91/185 (49%), Gaps = 20/185 (10%) Query: 23 YKYKEGYR--KQLGHHMGFRTLQDDPKSVWAIHAAKIQ---SDREYKKAYEKSKG-IHNT 76 +KYKE Y K G+ +G PK V +H ++ S+R Y++ Y K K IH T Sbjct: 4983 FKYKEAYEHTKAYGYTLG-------PKDVPFVHVRRVNNVTSERLYRELYHKLKDKIHTT 5035 Query: 77 PLDMMSIVQAKKCQVLVSDIDYRNYLHQWT----CLPDQNDVIQAKKAYDLQSDNLYKSD 132 P D I Q KK Q VS++ Y++ + LP VI + D+ SD YK D Sbjct: 5036 P-DTPEIRQVKKTQEAVSELIYKSDFFKMQGHMISLPYTPQVIHCRYVGDITSDIKYKED 5094 Query: 133 LEWLKGIGWLPEGSVEVMRVKNAQNLLNERLYRIKPEAL--KFTSIVDTPEVIQAKINAV 190 L+ LKG G + +++R ++ + L + LY K + K+ ++DTPE + + Sbjct: 5095 LQVLKGFGCFLYDTPDMVRSRHLRKLWSNYLYTDKARKMRDKYKVVLDTPEYRKVQELKT 5154 Query: 191 QISEV 195 +SE+ Sbjct: 5155 HLSEL 5159 Score = 72.4 bits (176), Expect = 3e-13 Identities = 66/231 (28%), Positives = 96/231 (41%), Gaps = 52/231 (22%) Query: 20 VPSYKYKEGYRKQLGHHMGFRTLQDDPKSVWAIHAAKIQSDREYKKAYEKSKGIHNTPLD 79 V KYK Y K + + D P + A A SD YK+ ++K+KG ++T D Sbjct: 5226 VSEKKYKIQYEKMKDK---YTPVPDTPILIRAKRAYWNASDLRYKETFQKTKGKYHTVKD 5282 Query: 80 MMSIVQAKKCQVLVSDIDYR-NYLHQ---WTCLPDQNDVIQAKKAYDLQSDNLYKSDLEW 135 + IV +K +S I Y+ NY+ Q W +PD+ + + D SD YK DL W Sbjct: 5283 ALDIVYHRKVTDDISKIKYKENYMSQLGIWRSIPDRPEHFHHRAVTDTVSDVKYKEDLTW 5342 Query: 136 LKGIG------------------------------------WLPEGSVEVMRVKNAQNLL 159 LKGIG ++ + + K A L+ Sbjct: 5343 LKGIGCYAYDTPDFTLAEKNKTLYSKYKYKEVFERTKSDFKYVADSPIN-RHFKYATQLM 5401 Query: 160 NERLYRIKPEAL--KFTSIVDTPEVIQAKINAVQISEV------EKSRDNF 202 NE+ YR E K+ +VD P + AK QIS++ EKS+D F Sbjct: 5402 NEKKYRADYEQRKDKYHLVVDEPRHLLAKTAGDQISQIKYRKNYEKSKDKF 5452 Score = 69.7 bits (169), Expect = 2e-12 Identities = 61/245 (24%), Positives = 111/245 (45%), Gaps = 54/245 (22%) Query: 22 SYKYKEGYRKQLGHHMGFRTLQDDPKSVWAIHAAKIQSDREYKKAYEKSKGIHNTPLDMM 81 SY+YK+ Y K GH + T+ D+ + + A ++QS +YK+ YEK +G + Sbjct: 5864 SYQYKKKYEKSKGH---YHTIPDNLEQLHLKEATELQSIVKYKEKYEKERGKPMLDFETP 5920 Query: 82 SIVQAKKCQVLVSDIDYRN-------------------YLH------------------- 103 + + AK+ Q + S +YR LH Sbjct: 5921 TYITAKESQQMQSGKEYRKDYEESIKGRNLTGLEVTPALLHVKYATKIASEKEYRKDLEE 5980 Query: 104 -----QWTCLPDQNDVIQAKKAYDLQSDNLYKSDLEWL---KGIGWLPEGSVEVMRVKNA 155 T + D D+++AK A + ++ YK DLE +G+ + + + MR +NA Sbjct: 5981 SIRGKGLTEMEDTPDMLRAKNATQILNEKEYKRDLELEVKGRGLNAMANETPDFMRARNA 6040 Query: 156 QNLLNERLYRIKPEALK--FTSIVDTPEVIQAKINAVQISEVEKSRDNF--NVRHYGSYL 211 ++ ++ Y+ E K FTS+VDTPE+I A+ +S +K +++ ++ +Y + L Sbjct: 6041 TDIASQIKYKQSAEMEKANFTSVVDTPEIIHAQ-QVKNLSSQKKYKEDAEKSMSYYETVL 6099 Query: 212 DQKQL 216 D ++ Sbjct: 6100 DTPEI 6104 Score = 60.5 bits (145), Expect = 1e-09 Identities = 54/191 (28%), Positives = 88/191 (46%), Gaps = 26/191 (13%) Query: 19 EVPSYKYKEGYRKQLGHHMGFRTLQDDPKSVWAIHAAKIQ---SDREYKKAYEKSKGIHN 75 ++ YK Y K G+ T+ D P +H K++ SD +YK+ Y+++K Sbjct: 5470 QISDILYKLEYNK--AKPRGYTTIHDTPM---LLHVRKVKDEVSDLKYKEVYQRNKSNCT 5524 Query: 76 TPLDMMSIVQAKKCQVLVSDIDYRNYLH----QWTCLPDQNDVIQAKKAYDLQSDNLYKS 131 D + I AK + +++DY+ W PD+ D +QA K+ QSD YK Sbjct: 5525 IEPDAVHIKAAKDAYKVNTNLDYKKQYEANKAHWKWTPDRPDFLQAAKSSLQQSDFEYKL 5584 Query: 132 DLEWLKGIGWLPEGSVEVMRVKNA----QNLLNERLYRIKPEALK----FTSIVDTPEVI 183 D E+LKG + V KN +N L E + K + +K ++ DTP+++ Sbjct: 5585 DREFLKGC------KLSVTDDKNTVLALRNTLIESDLKYKEKHVKERGTCHAVPDTPQIL 5638 Query: 184 QAKINAVQISE 194 AK + +SE Sbjct: 5639 LAKTVSNLVSE 5649 Score = 58.9 bits (141), Expect = 4e-09 Identities = 48/167 (28%), Positives = 78/167 (46%), Gaps = 13/167 (7%) Query: 41 TLQDDPKSVWAIHAAKIQSDREYKKAYEKSKGIHNTPLDMMSIVQAKKCQVLVSDIDYRN 100 ++ DD +V A+ I+SD +YK+ + K +G + D I+ AK LVS+ Y++ Sbjct: 5595 SVTDDKNTVLALRNTLIESDLKYKEKHVKERGTCHAVPDTPQILLAKTVSNLVSENKYKD 5654 Query: 101 YLHQ------WTCLPDQNDVIQAKKAYDLQSDNLYKSDLEWLKG-----IGWLPEGSVEV 149 ++ + +T LP+ D + K+ SD YK KG I P Sbjct: 5655 HVKKHLAQGSYTTLPETRDTVHVKEVTKHVSDTNYKKKFVKEKGKSNYSIMLEPPEVKHA 5714 Query: 150 MRVKNAQNLLNERLYRIKPEALKFTSIVDTPEVIQAKINAVQISEVE 196 M V Q+ + R + E L +T++ D P++ +A A Q SEVE Sbjct: 5715 MEVAKKQSDVAYR--KDAKENLHYTTVADRPDIKKATQAAKQASEVE 5759 Score = 57.8 bits (138), Expect = 8e-09 Identities = 45/189 (23%), Positives = 82/189 (43%), Gaps = 11/189 (5%) Query: 24 KYKEGYRKQLGH-HMGFRTLQDDPKSVWAIHAAKIQSDREYKKAYEKSKGIH----NTP- 77 KYKE Y K G ++P+ A SD+ YK+ YEK+K TP Sbjct: 347 KYKEDYEKNKGKADYNVLPASENPQLRQLKAAGDALSDKLYKENYEKTKAKSINYCETPK 406 Query: 78 LDMMSIVQAKKCQVLVSDIDYRNYLHQWTCLPDQNDVIQAKKAYDLQSDNLYKSDLEWLK 137 + +++Q D ++ L + + K SD YK++ E + Sbjct: 407 FKLDTVLQNFSSDKKYKDSYLKDILGHYVGSFEDPYHSHCMKVTAQNSDKNYKAEYEEDR 466 Query: 138 GIGWLPEGSVEVMRVKNAQNLLNERLYRIKPEALKFTSIVDTPEVIQAKINAVQISEVEK 197 G G+ P+ + + + Y++ P+ KFT + D+P ++QA++N+ Q+S++ Sbjct: 467 GKGFFPQTITQEYEAIKKLDQCKDHTYKVHPDKTKFTQVTDSPVLLQAQVNSKQLSDL-- 524 Query: 198 SRDNFNVRH 206 N+ +H Sbjct: 525 ---NYKAKH 530 Score = 57.8 bits (138), Expect = 8e-09 Identities = 51/177 (28%), Positives = 84/177 (47%), Gaps = 15/177 (8%) Query: 24 KYKEGYRKQLGHHMGFRTLQDDPKSVWAIHAAKIQSDREYKKAYEKSKGIHNTPLDMMSI 83 KYK+ + + F ++ D P+ + A + S ++YK+ EKS + T LD I Sbjct: 6048 KYKQSAEMEKAN---FTSVVDTPEIIHAQQVKNLSSQKKYKEDAEKSMSYYETVLDTPEI 6104 Query: 84 VQAKKCQ----VLVSDIDYRNYLHQWTCLPDQNDVIQAKKAYDLQSDNLYKSDLEWLKGI 139 + ++ Q +L D +N + T + D ++++ K+ S LYK D+ I Sbjct: 6105 QRVRENQKNFSLLQYQCDLKNSKGKITVVQDTPEILRVKENQKNFSSVLYKEDVSPGTAI 6164 Query: 140 GWLPEGSVEVMRVKNAQNLLNERLYRIKPEAL-KFTSIVDTPEVIQAKINAVQISEV 195 G P E+MRVK Q+ ++ Y+ EA+ + T I D PEV + K IS V Sbjct: 6165 GKTP----EMMRVKQTQDHISSVKYK---EAIGQGTPIPDLPEVKRVKETQKHISSV 6214 Score = 52.8 bits (125), Expect = 3e-07 Identities = 51/183 (27%), Positives = 78/183 (42%), Gaps = 9/183 (4%) Query: 19 EVPSYKYKEGYRKQLGHHMGFRTLQDDPKSVWAIHAAKIQSDREYKKAYEKSKGIHNTPL 78 ++ KYKE Y QLG +R++ D P+ SD +YK+ KGI Sbjct: 5295 DISKIKYKENYMSQLGI---WRSIPDRPEHFHHRAVTDTVSDVKYKEDLTWLKGIGCYAY 5351 Query: 79 DMMSIVQAKKCQVLVSDIDYRNYLHQ----WTCLPDQNDVIQAKKAYDLQSDNLYKSDLE 134 D A+K + L S Y+ + + + D K A L ++ Y++D E Sbjct: 5352 DTPDFTLAEKNKTLYSKYKYKEVFERTKSDFKYVADSPINRHFKYATQLMNEKKYRADYE 5411 Query: 135 WLKGIGWLPEGSVEVMRVKNAQNLLNERLYRIKPEAL--KFTSIVDTPEVIQAKINAVQI 192 K L + K A + +++ YR E KFTSIVDTPE ++ QI Sbjct: 5412 QRKDKYHLVVDEPRHLLAKTAGDQISQIKYRKNYEKSKDKFTSIVDTPEHLRTTKVNKQI 5471 Query: 193 SEV 195 S++ Sbjct: 5472 SDI 5474 Score = 52.0 bits (123), Expect = 4e-07 Identities = 42/165 (25%), Positives = 79/165 (47%), Gaps = 7/165 (4%) Query: 29 YRKQLGHHMGFRT-LQDDPKSVWAIHAAKIQSDREYKKAYEKSKGIHNTPLDMMSIVQAK 87 Y++ L GF L D P V + H K+ S+ Y K + + LD + + Sbjct: 5091 YKEDLQVLKGFGCFLYDTPDMVRSRHLRKLWSNYLYTDKARKMRDKYKVVLDTPEYRKVQ 5150 Query: 88 KCQVLVSDIDYR----NYLHQWTCLPDQNDVIQAKKAYDLQSDNLYKSDLEWLKGIGWLP 143 + + +S++ YR +T +PD D+++AK+ LQS LY + Sbjct: 5151 ELKTHLSELVYRAAGKKQKSIFTSVPDTPDLLRAKRGQKLQSQYLYVELATKERPHHHAG 5210 Query: 144 EGSVEVMRVKNAQNLLNERLYRIKPEAL--KFTSIVDTPEVIQAK 186 + + K+ +++++E+ Y+I+ E + K+T + DTP +I+AK Sbjct: 5211 NQTTALKHAKDVKDMVSEKKYKIQYEKMKDKYTPVPDTPILIRAK 5255 Score = 51.2 bits (121), Expect = 8e-07 Identities = 55/208 (26%), Positives = 95/208 (45%), Gaps = 15/208 (7%) Query: 25 YKEGYRKQLGHHMGFRTLQDDPKSVWAIHAAKIQSDREYKKAYEKSKGIHNTPLDMMSIV 84 YK+ Y H ++ D P + A ++ QSD EYK E KG + D + V Sbjct: 5547 YKKQYEANKAH---WKWTPDRPDFLQAAKSSLQQSDFEYKLDREFLKGCKLSVTDDKNTV 5603 Query: 85 QAKKCQVLVSDIDYR--NYLHQWTC--LPDQNDVIQAKKAYDLQSDNLYKSDLEWLKGIG 140 A + ++ SD+ Y+ + + TC +PD ++ AK +L S+N YK ++ G Sbjct: 5604 LALRNTLIESDLKYKEKHVKERGTCHAVPDTPQILLAKTVSNLVSENKYKDHVKKHLAQG 5663 Query: 141 ---WLPEGSVEVMRVKNAQNLLNERLYRIKPEALK----FTSIVDTPEVIQAKINAVQIS 193 LPE + + + VK +++ Y+ K K ++ +++ PEV A A + S Sbjct: 5664 SYTTLPE-TRDTVHVKEVTKHVSDTNYKKKFVKEKGKSNYSIMLEPPEVKHAMEVAKKQS 5722 Query: 194 EVEKSRDNFNVRHYGSYLDQKQLGPAQQ 221 +V +D HY + D+ + A Q Sbjct: 5723 DVAYRKDAKENLHYTTVADRPDIKKATQ 5750 Score = 50.4 bits (119), Expect = 1e-06 Identities = 50/187 (26%), Positives = 82/187 (43%), Gaps = 10/187 (5%) Query: 24 KYKEGYRKQLGHHMGFRTLQDDPKSVWAIHAAKIQ-SDREYKKAYEKSKGIHNTPLDMMS 82 KYKE + K G T D + I + Q S+ +Y+ + +K I + Sbjct: 100 KYKEKFEKTKGQPYASTT---DTPELRRIKKVQDQLSEVKYRMDGDVAKTICHVDEKAKD 156 Query: 83 IVQAKKCQVLVSDIDYRNYLH----QWTCLPDQNDVIQAKKAYDLQSDNLYKSDLEWLKG 138 I AKK VS + Y+ ++ PD +++QA K + S LY D E K Sbjct: 157 IEHAKKVSQQVSKVLYKQNWEDTKDKYLLPPDAPELVQAVKNTAMFSKKLYTEDWEADKS 216 Query: 139 IGWLPEGSVEVMRVKNAQNLLNERLYR--IKPEALKFTSIVDTPEVIQAKINAVQISEVE 196 + + S E+ RV AQ L++ Y+ + + +FT + D P++ AK Q+S+ + Sbjct: 217 LFYPYNDSPELRRVAQAQKALSDVAYKKGLAEQQAQFTPLADPPDIEFAKKVTNQVSKQK 276 Query: 197 KSRDNFN 203 D N Sbjct: 277 YKEDYEN 283 Score = 50.1 bits (118), Expect = 2e-06 Identities = 56/205 (27%), Positives = 82/205 (40%), Gaps = 43/205 (20%) Query: 44 DDPKSVWAIHAAKIQSDREYKKAYEKSKGIHNTPLDMMSIVQAKKCQVLVSDIDYR-NYL 102 D P+ + A HA ++ D +YK K++ + D VQA K +SD Y +Y+ Sbjct: 4860 DTPEILHAKHAYDLRDDIKYKAHMLKTRNDYKLVTDTPVYVQAVKSGKQLSDAVYHYDYV 4919 Query: 103 H--QWTCLPDQN--DVIQAKKAYDLQSDNLYKSDLEWL---------------------- 136 H + P D+ +A AY LQS NLYK+ L L Sbjct: 4920 HSVRGKVAPTTKTVDLDRALHAYKLQSSNLYKTSLRTLPTGYRLPGDTPHFKHIKDTRYM 4979 Query: 137 -------------KGIGW-LPEGSVEVMRVKNAQNLLNERLYRIKPEALK--FTSIVDTP 180 K G+ L V + V+ N+ +ERLYR LK + DTP Sbjct: 4980 SSYFKYKEAYEHTKAYGYTLGPKDVPFVHVRRVNNVTSERLYRELYHKLKDKIHTTPDTP 5039 Query: 181 EVIQAKINAVQISEVEKSRDNFNVR 205 E+ Q K +SE+ D F ++ Sbjct: 5040 EIRQVKKTQEAVSELIYKSDFFKMQ 5064 Score = 48.1 bits (113), Expect = 6e-06 Identities = 48/175 (27%), Positives = 89/175 (50%), Gaps = 24/175 (13%) Query: 51 AIHAAKIQSDREYKKAYEKSK--GIHNTPLDMMSIVQAKKCQVLVSDIDYR----NYLHQ 104 A A+ I ++++Y++ + K I + P+ VQ+K Q SDI Y+ +H+ Sbjct: 972 AKRASDILNEKKYRQHPDTLKFTSIEDAPIT----VQSKINQAQRSDIAYKAKGEEIIHK 1027 Query: 105 WTCLPDQNDVIQAK-KAYDLQSDNLYKSDLEWLKGIGW-LPEGSVEVMRVKNAQNLLNER 162 + PD IQAK AY++ S+N+YK+DL+ L G+ L ++ + K A+ ++ Sbjct: 1028 YNLPPDLPQFIQAKVNAYNI-SENMYKADLKDLSKKGYDLRTDAIPIRAAKAARQAASDV 1086 Query: 163 LY-----RIKPEALKFTSIVDTPEVIQ----AKINAVQ--ISEVEKSRDNFNVRH 206 Y + K + + F S+ D P+++ AKI + + + EK++ +N H Sbjct: 1087 QYKKDYEKAKGKMVGFQSLQDDPKLVHYMNVAKIQSDREYKKDYEKTKSKYNTPH 1141 Score = 47.8 bits (112), Expect = 8e-06 Identities = 45/184 (24%), Positives = 83/184 (45%), Gaps = 10/184 (5%) Query: 24 KYKEGYRKQLGHHMGFRTLQDDPKSVWAIHAAKIQSDREYKKAYEKSKGIHNTPLDMMSI 83 KY+ Y ++ + + D+P+ + A A S +Y+K YEKSK + +D Sbjct: 5405 KYRADYEQRKDK---YHLVVDEPRHLLAKTAGDQISQIKYRKNYEKSKDKFTSIVDTPEH 5461 Query: 84 VQAKKCQVLVSDIDYRNYLHQ-----WTCLPDQNDVIQAKKAYDLQSDNLYKSDLEWLKG 138 ++ K +SDI Y+ ++ +T + D ++ +K D SD YK + K Sbjct: 5462 LRTTKVNKQISDILYKLEYNKAKPRGYTTIHDTPMLLHVRKVKDEVSDLKYKEVYQRNKS 5521 Query: 139 IGWLPEGSVEVMRVKNAQNLLNERLYRIKPEALK--FTSIVDTPEVIQAKINAVQISEVE 196 + +V + K+A + Y+ + EA K + D P+ +QA +++Q S+ E Sbjct: 5522 NCTIEPDAVHIKAAKDAYKVNTNLDYKKQYEANKAHWKWTPDRPDFLQAAKSSLQQSDFE 5581 Query: 197 KSRD 200 D Sbjct: 5582 YKLD 5585 Score = 47.0 bits (110), Expect = 1e-05 Identities = 50/191 (26%), Positives = 77/191 (40%), Gaps = 48/191 (25%) Query: 56 KIQSDREYKKAY-EKSKGIHNTPLDMMSIVQAKKCQVLVSDIDYRN-------------- 100 +IQSD EYK+ Y E KG+ +P + + +AKK SD YR Sbjct: 2161 RIQSDNEYKQDYNEWYKGLGWSPAGSLEVEKAKKATEYASDQKYRQHPSNFQFKKLTDSM 2220 Query: 101 ----------------YLHQWT-------CLPDQNDVIQAKKAYDLQSDNLYKSDLEWLK 137 Y W +PD D++QAK+ L S LYK E Sbjct: 2221 DMVLAKQNAHTMNKHLYTIDWNKDKTKIHVMPDTPDILQAKQNQTLYSQKLYKLGWEEAL 2280 Query: 138 GIGW-LPEGSVEVMRVKNAQNLLNERLYRIKPEALK-------FTSIVDTPEVIQAKINA 189 G+ LP ++ V K ++++ ++ Y+ K K F S+ D P+++ + A Sbjct: 2281 KKGYDLPVDAISVQLAKASRDIASD--YKYKQGYRKQLGHHVGFRSLQDDPKLVLSMNVA 2338 Query: 190 VQISEVEKSRD 200 SE E +D Sbjct: 2339 KMQSEREYKKD 2349 Score = 47.0 bits (110), Expect = 1e-05 Identities = 38/159 (23%), Positives = 72/159 (45%), Gaps = 7/159 (4%) Query: 44 DDPKSVWAIHAAKIQSDREYKKAYEKSKGIHNTPLDMMSIVQAKKCQVLVSDIDYRNYLH 103 D P+ + A + +QS +Y A +++ +N D V A + + S++ Y+ H Sbjct: 4615 DTPQILHAKKSYDLQSQLQYTAAGKENLQNYNLVTDTPLYVTAVQSGINASEVKYKENYH 4674 Query: 104 Q----WTCLPDQNDVIQAKKAYDLQSDNLYKSDLEWLKGIGW-LPEGSVEVMRVKNAQNL 158 Q +T + + D + + +L S NLYK + +K + LP ++ + KN ++L Sbjct: 4675 QIKDKYTTVLETVDYDRTRNLKNLYSSNLYKEAWDRVKATSYILPSSTLSLTHAKNQKHL 4734 Query: 159 LNERLYRIKPEALKFTSIVDTPEVIQAKINAVQISEVEK 197 + YR + E KF ++ P + N + V K Sbjct: 4735 ASHIKYREEYE--KFKALYTLPRSVDDDPNTARCLRVGK 4771 Score = 46.6 bits (109), Expect = 2e-05 Identities = 53/202 (26%), Positives = 83/202 (41%), Gaps = 9/202 (4%) Query: 19 EVPSYKYKEGYRKQLGHHMGFRTLQDDPKSVWAIHAAKIQSDREYKKAYEKSKGIHNTPL 78 EV + YRK ++ + T+ D P A AAK S+ EY+ + K + L Sbjct: 5716 EVAKKQSDVAYRKDAKENLHYTTVADRPDIKKATQAAKQASEVEYRAKHRKEGSHGLSML 5775 Query: 79 DMMSIVQAKKCQVLVSDIDYR-NYLHQWTCLPDQNDVIQ-----AKKAYDLQSDNLYKSD 132 I AKK L S + YR N+ + P N K A +L S+ YK+D Sbjct: 5776 GRPDIEMAKKAAKLSSQVKYRENFDKEKGKTPKYNPKDSQLYKVMKDANNLASEVKYKAD 5835 Query: 133 LEWLKGIGWLPEGSVEVMRVKNAQNLLNERLYRIKPEALK--FTSIVDTPEVIQAKINAV 190 L+ L + S+ + V N L + Y+ K E K + +I D E + K A Sbjct: 5836 LKKLHKPVTDMKESLIMNHVLNTSQLASSYQYKKKYEKSKGHYHTIPDNLEQLHLK-EAT 5894 Query: 191 QISEVEKSRDNFNVRHYGSYLD 212 ++ + K ++ + LD Sbjct: 5895 ELQSIVKYKEKYEKERGKPMLD 5916 Score = 45.8 bits (107), Expect = 3e-05 Identities = 39/145 (26%), Positives = 65/145 (44%), Gaps = 8/145 (5%) Query: 29 YRKQLGHHMGFRTLQDDPKSVWAIHAAKIQSDREYKKAYEKSKGI-HNTPLDMMSIVQAK 87 YRK TL + P A AA+I YK+ +E+ K + P D + V A Sbjct: 4180 YRKDWNATKSKYTLTETPLLHTAQEAARILDQYLYKEGWERQKATGYILPPDAVPFVHAH 4239 Query: 88 KCQVLVSDIDYR-NYLHQ---WTCLPDQND---VIQAKKAYDLQSDNLYKSDLEWLKGIG 140 C + S++ Y+ ++ Q + +P D ++ + A +Q++ LYK D K Sbjct: 4240 HCNDVQSELKYKAEHVKQKGHYVGVPTMRDDPKLVWFEHAGQIQNERLYKEDYHKTKAKI 4299 Query: 141 WLPEGSVEVMRVKNAQNLLNERLYR 165 +P V V+ K Q L+++ YR Sbjct: 4300 NIPADMVSVLAAKQGQTLVSDIDYR 4324 Score = 44.3 bits (103), Expect = 9e-05 Identities = 42/158 (26%), Positives = 70/158 (44%), Gaps = 10/158 (6%) Query: 39 FRTLQDDPKSVWAIHAAKIQSDREYKKAYEKSKGIHNTPLDMMSIVQAKKCQVLVSDIDY 98 F ++ D V A H K SD YK EK K + ++ +QAK + +SD Y Sbjct: 1481 FTSVPDSMGMVLAQHNTKQLSDLNYKVEGEKLKHKYTIDPELPQFIQAKVNALNMSDAHY 1540 Query: 99 -----RNYLHQWTCLPDQNDVIQAKKAYDLQSDNLYKSDLEWLKG--IGWLP-EGSVEVM 150 + + PD ++ AK + ++ SD YK E KG +G+L + +++ Sbjct: 1541 KADWKKTIAKGYDLRPDAIPIVAAKSSRNIASDCKYKEAYEKAKGKQVGFLSLQDDPKLV 1600 Query: 151 RVKNAQNLLNERLYRIKPEA--LKFTSIVDTPEVIQAK 186 N + ++R Y+ EA K+ + +D V AK Sbjct: 1601 HYMNVAKIQSDREYKKGYEASKTKYHTPLDMVSVTAAK 1638 Score = 43.5 bits (101), Expect = 2e-04 Identities = 35/106 (33%), Positives = 53/106 (50%), Gaps = 7/106 (6%) Query: 39 FRTLQDDPKSVWAIHAAKIQSDREYKKAYEKSK-GIHNTPLDMMSIVQAKKCQVLVSDID 97 + TL D V A + AKI ++ YK+A+E K +H P D+ I+ AK + +SD Sbjct: 1969 YSTLMDSMNMVLAQNNAKIMNEHLYKQAWEADKTKVHIMP-DIPQIILAKANAINMSDKL 2027 Query: 98 YRNYLHQ-----WTCLPDQNDVIQAKKAYDLQSDNLYKSDLEWLKG 138 Y+ L + + PD + AK + D+ SD YK + E KG Sbjct: 2028 YKLSLEESKKKGYDLRPDAIPIKAAKASRDIASDYKYKYNYEKGKG 2073 Score = 43.1 bits (100), Expect = 2e-04 Identities = 41/155 (26%), Positives = 63/155 (40%), Gaps = 41/155 (26%) Query: 52 IHAAK---IQSDREYKKAYEKSKGIHNTPLDMMSIVQAKKCQVLVSDIDYRN-------- 100 IHA K +QSD YK E KGI P+D + +V+AK+ L+SD YR Sbjct: 3370 IHARKAYDLQSDNLYKSDLEWMKGIGWVPIDSLEVVRAKRAGELLSDTIYRQRPETLKFT 3429 Query: 101 ----------------------YLHQWT-------CLPDQNDVIQAKKAYDLQSDNLYKS 131 Y W +PD +++ AK SD LYK Sbjct: 3430 SITDTPEQVLAKNNALNMNKRLYTEAWDNDKKTIHVMPDTPEIMLAKLNRINYSDKLYKL 3489 Query: 132 DLEWLKGIGW-LPEGSVEVMRVKNAQNLLNERLYR 165 LE K G+ L ++ + K ++++ ++ Y+ Sbjct: 3490 ALEESKKEGYDLRLDAIPIQAAKASRDIASDYKYK 3524 Score = 42.7 bits (99), Expect = 3e-04 Identities = 37/161 (22%), Positives = 69/161 (42%), Gaps = 9/161 (5%) Query: 42 LQDDPKSVWAIHAAKIQSDREYKKAYEKSKGIHNTPLDMMSIVQAKKCQVLVSDIDYRNY 101 L D + A A +QSD YK E +GI P+ + + + K+ ++SD YR Sbjct: 3606 LPDQNDVIQARKAYDLQSDAIYKSDLEWLRGIGWVPIGSVEVEKVKRAGEILSDRKYRQP 3665 Query: 102 LHQ--WTCLPDQNDVIQAKKAYDLQSDNLYKSDLEWLKGIGWLPEGSVEVMRVKNAQNLL 159 Q +TC+ D +++ AK S +LY + K + + +++ K+ + Sbjct: 3666 ADQLKFTCITDTPEIVLAKNNALTMSKHLYTEAWDADKTSIHVMPDTPDILLAKSNSANI 3725 Query: 160 NERLYRIKPEALKFTSIVDTPEVIQAKINAVQISEVEKSRD 200 +++LY + K + +A+ I + SRD Sbjct: 3726 SQKLYTKGWDESKMKD-------YDLRADAISIKSAKASRD 3759 Score = 42.0 bits (97), Expect = 5e-04 Identities = 46/217 (21%), Positives = 94/217 (43%), Gaps = 53/217 (24%) Query: 29 YRKQLGHHMGFRTLQDDPKSV-WAIHAAKIQSDREYKKAYEK-SKGIHNTPLDMMSIVQA 86 YR+ H+ TL D +V + +A +IQSD YK + KGI P++ + + +A Sbjct: 1649 YRQSYHHY----TLLPDALNVEHSRNAMQIQSDNLYKSDFTNWMKGIGWVPIESLEVEKA 1704 Query: 87 KKCQVLVSDIDYRN------------------------------YLHQWT-------CLP 109 KK ++S+ YR Y +W +P Sbjct: 1705 KKAGEILSEKKYRQHPEKLKFTYAMDTMEQALNKSNKLNMDKRLYTEKWNKDKTTIHVMP 1764 Query: 110 DQNDVIQAKKAYDLQSDNLYKSDLEWLKGIGW-LPEGSVEVMRVKNAQNLLNERLYR--- 165 D D++ ++ SD LYK+ E K G+ L ++ + + ++++ ++ Y+ Sbjct: 1765 DTPDILLSRVNQITMSDKLYKAGWEEEKKKGYDLRPDAIAIKAARASRDIASDYKYKKAY 1824 Query: 166 --IKPEALKFTSIVDTPEVIQAKINAVQISEVEKSRD 200 K + + F S+ D P++ ++ +Q+++++ R+ Sbjct: 1825 EQAKGKHIGFRSLEDDPKL----VHFMQVAKMQSDRE 1857 Score = 42.0 bits (97), Expect = 5e-04 Identities = 46/206 (22%), Positives = 84/206 (40%), Gaps = 48/206 (23%) Query: 39 FRTLQDDPKSVWAIHAAKIQSDREYKKAY-EKSKGIHNTPLDMMSIVQAKKCQVLVSDID 97 + L D A + +IQSD +YK Y + KGI PL + + KK ++S+ Sbjct: 1900 YNMLPDAMSFELAKNMMQIQSDNQYKADYADFMKGIGWLPLGSLEAEKNKKAMEIISEKK 1959 Query: 98 YRN------------------------------YLHQWTC-------LPDQNDVIQAKKA 120 YR Y W +PD +I AK Sbjct: 1960 YRQHPDTLKYSTLMDSMNMVLAQNNAKIMNEHLYKQAWEADKTKVHIMPDIPQIILAKAN 2019 Query: 121 YDLQSDNLYKSDLEWLKGIGW-LPEGSVEVMRVKNAQNLLNERLYRI-----KPEALKFT 174 SD LYK LE K G+ L ++ + K ++++ ++ Y+ K + + F Sbjct: 2020 AINMSDKLYKLSLEESKKKGYDLRPDAIPIKAAKASRDIASDYKYKYNYEKGKGKMVGFR 2079 Query: 175 SIVDTPEVIQAKINAVQISEVEKSRD 200 S+ D P++ ++++Q+++++ R+ Sbjct: 2080 SLEDDPKL----VHSMQVAKMQSDRE 2101 Score = 41.6 bits (96), Expect = 6e-04 Identities = 42/154 (27%), Positives = 65/154 (42%), Gaps = 10/154 (6%) Query: 42 LQDDPKSVWAIHAAKIQSDREYKKAYEKSKGIHNTPLDMMSIVQAKKCQVLVSDIDYRNY 101 +QD P+ + K S YK+ I TP +++ K+ Q +S + Y+ Sbjct: 6133 VQDTPEILRVKENQKNFSSVLYKEDVSPGTAIGKTP----EMMRVKQTQDHISSVKYKEA 6188 Query: 102 LHQWTCLPDQNDVIQAKKAYDLQSDNLYKSDLEWLKGIGWLPEGSVEVMRVKNAQNLLNE 161 + Q T +PD +V + K+ S +YK +L G G + E+ RVK Q + Sbjct: 6189 IGQGTPIPDLPEVKRVKETQKHISSVMYKENL----GTGIPTTVTPEIERVKRNQENFSS 6244 Query: 162 RLYRIKPEALKFTSIVDTPEVIQAKINAVQISEV 195 LY K K TPE+ + K N S V Sbjct: 6245 VLY--KENLGKGIPTPITPEMERVKRNQENFSSV 6276 Score = 40.0 bits (92), Expect = 0.002 Identities = 43/151 (28%), Positives = 67/151 (44%), Gaps = 16/151 (10%) Query: 24 KYKEGYRKQLGHHMGFRTLQDDPKSVWAIHAAKIQSDREYKKAYEKSKGIHNTPLDMMSI 83 KYK + L ++ FR++ D P+ V A + QSD +YK+ + K+KG + D I Sbjct: 4388 KYK---KNALENYPNFRSVVDPPEIVLAKINSVNQSDVKYKETFNKAKGKYTFSPDTPHI 4444 Query: 84 VQAKKCQVLVSDIDYR-----NYLHQWTCLPDQNDVIQAKKAYDLQSDNLYKSDLEWLKG 138 +K L S I Y+ + +T ++ AK A + S+ YK E KG Sbjct: 4445 SHSKDMGKLYSTILYKGAWEGTKAYGYTLDERYIPIVGAKHADLVNSELKYKETYEKQKG 4504 Query: 139 -------IGWLPEGSVEVMRVKNAQNLLNER 162 IG P G V + + ++ LN R Sbjct: 4505 HYLAGKVIGEFP-GVVHCLDFQKMRSALNYR 4534 Score = 40.0 bits (92), Expect = 0.002 Identities = 32/123 (26%), Positives = 59/123 (47%), Gaps = 7/123 (5%) Query: 23 YKYKEGYRKQLGHHMGFRTLQDDPKSVWAIHAAKIQSDREYKKAYEKSKGIHNTPLDMMS 82 YKYKE + + F+ + D P + +A ++ ++++Y+ YE+ K ++ +D Sbjct: 5369 YKYKEVFERTKSD---FKYVADSPINRHFKYATQLMNEKKYRADYEQRKDKYHLVVDEPR 5425 Query: 83 IVQAKKCQVLVSDIDYR-NY---LHQWTCLPDQNDVIQAKKAYDLQSDNLYKSDLEWLKG 138 + AK +S I YR NY ++T + D + ++ K SD LYK + K Sbjct: 5426 HLLAKTAGDQISQIKYRKNYEKSKDKFTSIVDTPEHLRTTKVNKQISDILYKLEYNKAKP 5485 Query: 139 IGW 141 G+ Sbjct: 5486 RGY 5488 Score = 40.0 bits (92), Expect = 0.002 Identities = 41/152 (26%), Positives = 64/152 (42%), Gaps = 8/152 (5%) Query: 20 VPSYKYKEGYRKQLGHHMGFRTLQDDPKSVWAIHAAKIQSDREYKKAYEKSKGIHN--TP 77 V KYK+ +K L + TL + +V K SD YKK + K KG N Sbjct: 5647 VSENKYKDHVKKHLAQG-SYTTLPETRDTVHVKEVTKHVSDTNYKKKFVKEKGKSNYSIM 5705 Query: 78 LDMMSIVQAKKCQVLVSDIDYR----NYLHQWTCLPDQNDVIQAKKAYDLQSDNLYKSDL 133 L+ + A + SD+ YR LH +T + D+ D+ +A +A S+ Y++ Sbjct: 5706 LEPPEVKHAMEVAKKQSDVAYRKDAKENLH-YTTVADRPDIKKATQAAKQASEVEYRAKH 5764 Query: 134 EWLKGIGWLPEGSVEVMRVKNAQNLLNERLYR 165 G G ++ K A L ++ YR Sbjct: 5765 RKEGSHGLSMLGRPDIEMAKKAAKLSSQVKYR 5796 Score = 39.3 bits (90), Expect = 0.003 Identities = 34/117 (29%), Positives = 58/117 (49%), Gaps = 7/117 (5%) Query: 54 AAKIQSDREYKKAYEKSKGIHNTPLDMMSIVQAKKCQVLVSDIDYRNYLH----QWTCLP 109 A++I S+++Y++ +++K + D M IV AK SD YR Q +P Sbjct: 2438 ASEIISEKKYRQPPDRNK--FTSIPDAMDIVLAKTNAKNRSDRLYREAWDKDKTQIHIMP 2495 Query: 110 DQNDVIQAKKAYDLQSDNLYKSDLEWLKGIGW-LPEGSVEVMRVKNAQNLLNERLYR 165 D D++ AK SD LY+ E LK G+ LP ++ + K ++ + +E Y+ Sbjct: 2496 DTPDIVLAKANLINTSDKLYRMGYEELKRKGYDLPVDAIPIKAAKASREIASEYKYK 2552 Score = 38.9 bits (89), Expect = 0.004 Identities = 54/207 (26%), Positives = 85/207 (41%), Gaps = 17/207 (8%) Query: 39 FRTLQDDPKSVWAIHAAKIQSDREYKKAYEKSKGIHNTPLDMMSIVQAKKCQVLVSDIDY 98 F +++D P +V + +SD YK E+ +N P D+ +QAK +S+ Y Sbjct: 993 FTSIEDAPITVQSKINQAQRSDIAYKAKGEEIIHKYNLPPDLPQFIQAKVNAYNISENMY 1052 Query: 99 RNYLHQ-----WTCLPDQNDVIQAKKAYDLQSDNLYKSDLEWLKG--IGWLP-EGSVEVM 150 + L + D + AK A SD YK D E KG +G+ + +++ Sbjct: 1053 KADLKDLSKKGYDLRTDAIPIRAAKAARQAASDVQYKKDYEKAKGKMVGFQSLQDDPKLV 1112 Query: 151 RVKNAQNLLNERLYRIKPEALKFTSIVDTPEVIQAKINAVQISEVEKSRDNFNVRHYGSY 210 N + ++R Y K + K S +TP + N V + + N N +H S Sbjct: 1113 HYMNVAKIQSDREY--KKDYEKTKSKYNTPHDM---FNVVAAKKAQDVVSNVNYKH--SL 1165 Query: 211 LDQKQLGPAQQWELSELSAMWTYPSDN 237 L A ELS+ M SDN Sbjct: 1166 HHYTYLPDAMDLELSK--NMMQIQSDN 1190 Score = 37.7 bits (86), Expect = 0.009 Identities = 38/142 (26%), Positives = 59/142 (41%), Gaps = 8/142 (5%) Query: 39 FRTLQDDPKSVWAIHAAKIQSDREYKKAYEKSKGIHNTPLDMMSIVQAKKCQVLVSDIDY 98 F ++ D P V A K SD YK E K + D+ +QAK +SD+ Y Sbjct: 1237 FTSIVDSPVMVQAKQNTKQVSDILYKAKGEDVKHKYTMSPDLPQFLQAKCNAYNISDVCY 1296 Query: 99 RNYLHQW-----TCLPDQNDVIQAKKAYDLQSDNLYKSDLEWLKG--IGWLP-EGSVEVM 150 + H L D + AK + ++ SD YK E KG +G+ + +++ Sbjct: 1297 KRDWHDLIAKGNNVLGDAIPITAAKASRNIASDYKYKEAYEKSKGKHVGFRSLQDDPKLV 1356 Query: 151 RVKNAQNLLNERLYRIKPEALK 172 N L ++R Y+ E K Sbjct: 1357 HYMNVAKLQSDREYKKNYENTK 1378 Score = 37.4 bits (85), Expect = 0.011 Identities = 56/207 (27%), Positives = 85/207 (41%), Gaps = 21/207 (10%) Query: 5 CLFPKPHTYDLS----LPEVPSYKYKEGYRKQLGHHMGFRTLQDDPKSVWAIHAAKIQSD 60 C FP+ T + L + + YK K F + D P + A K SD Sbjct: 716 CYFPQTITQEYEAIKKLDQCKDHTYKVHPDKTK-----FTAVTDSPVLLQAQLNTKQLSD 770 Query: 61 REYKKAYEKSKGIHNTPLDMMSIVQAKKCQVLVSDIDY-----RNYLHQWTCLPDQNDVI 115 YK +E K + P D +Q + +SD Y ++ ++ D ++ Sbjct: 771 LNYKAKHEGEKFKCHIPADAPQFIQHRVNAYNLSDNVYKQDWEKSKAKKFDIKVDAIPLL 830 Query: 116 QAKKAYDLQSDNLYKSDLEWLKG--IGWLPEGSVEVM--RVKNAQNLLNERLYRIKPEAL 171 AK SD +YK D E KG IG L M +K A+N ++R YR E Sbjct: 831 AAKANTKNTSDVMYKKDYEKSKGKMIGALSINDDPKMLHSLKTAKN-QSDREYRKDYEKS 889 Query: 172 K--FTSIVDTPEVIQAKINAVQISEVE 196 K +T+ +D +V QAK + S+V+ Sbjct: 890 KTIYTAPLDMLQVTQAKKSQAIASDVD 916 Score = 37.4 bits (85), Expect = 0.011 Identities = 38/168 (22%), Positives = 70/168 (41%), Gaps = 10/168 (5%) Query: 39 FRTLQDDPKSVWAIHAAKIQSDREYKKAYEKSKGIHNTPLDMMSIVQAKKCQVLVSDIDY 98 + + D P V A+ + S+ +YK+ Y + K + T L+ + + + + L S Y Sbjct: 4645 YNLVTDTPLYVTAVQSGINASEVKYKENYHQIKDKYTTVLETVDYDRTRNLKNLYSSNLY 4704 Query: 99 RNYLHQWTC----LPDQN-DVIQAKKAYDLQSDNLYKSDLEWLKGIGWLP---EGSVEVM 150 + + LP + AK L S Y+ + E K + LP + Sbjct: 4705 KEAWDRVKATSYILPSSTLSLTHAKNQKHLASHIKYREEYEKFKALYTLPRSVDDDPNTA 4764 Query: 151 RVKNAQNLLNERLYR--IKPEALKFTSIVDTPEVIQAKINAVQISEVE 196 R L +RLYR + +K + D E++ AK + ++SE++ Sbjct: 4765 RCLRVGKLNIDRLYRSVYEKNKMKIHIVPDMVEMVTAKDSQKKVSEID 4812 Score = 36.2 bits (82), Expect = 0.025 Identities = 33/162 (20%), Positives = 65/162 (40%), Gaps = 38/162 (23%) Query: 42 LQDDPKSVWAIHAAKIQSDREYKKAYEKSKGIHNTPLDMMSIVQAKKCQVLVSDIDYRN- 100 L D + A A +QSD YK + +GI P+ M +V+ K+ ++SD YR Sbjct: 3120 LPDQNDVIHARQAYDLQSDNIYKSDLQWLRGIGWVPIGSMDVVKCKRAAEILSDNIYRQP 3179 Query: 101 -----------------------------YLHQWT-------CLPDQNDVIQAKKAYDLQ 124 Y W +PD +++ A++ Sbjct: 3180 PDKLKFTSVTDSLEQVLAKNNALNMNKRLYTEAWDKDKTQVHIMPDTPEIMLARQNKINY 3239 Query: 125 SDNLYKSDLEWLKGIGW-LPEGSVEVMRVKNAQNLLNERLYR 165 S++LY+ +E K G+ L ++ ++ K ++++ ++ Y+ Sbjct: 3240 SESLYRQAMEEAKKEGYDLRSDAIPIVAAKASRDIASDYKYK 3281 Score = 32.3 bits (72), Expect = 0.37 Identities = 44/154 (28%), Positives = 67/154 (43%), Gaps = 12/154 (7%) Query: 39 FRTLQDDPKSVWAIHAAKIQSDREYKKAYEKSKGIHNTPLDMMSIVQAKKCQVLVSDIDY 98 F + D P + A +K SD YK +E K + P D + +Q K +SD Y Sbjct: 502 FTQVTDSPVLLQAQVNSKQLSDLNYKAKHESEKFKCHIPPDTPAFIQHKVNAYNLSDNLY 561 Query: 99 -----RNYLHQWTCLPDQNDVIQAKKAYDLQSDNLYKSDLEWLKG--IGWLPEGSVEVM- 150 ++ ++ D ++ AK SD +YK D E KG IG L M Sbjct: 562 KQDWEKSKAKKFDIKVDAIPLLAAKANTKNTSDVMYKKDYEKNKGKMIGVLSINDDPKML 621 Query: 151 -RVKNAQNLLNERLYRIKPEALKFTSI--VDTPE 181 +K A+N ++RLY+ E K S+ +TP+ Sbjct: 622 HSLKVAKN-QSDRLYKENYEKTKAKSMNYCETPK 654 Score = 32.3 bits (72), Expect = 0.37 Identities = 39/161 (24%), Positives = 75/161 (46%), Gaps = 20/161 (12%) Query: 13 YDLSLPEVPSYKYKEGYRKQLGHHMGFRTLQDDPKSVWAIHAAKIQSDREYKKAYEKSKG 72 YDL + YK + K +G M +L+D+ A +I SD Y++ ++ K Sbjct: 2647 YDLQSDNL--YKSDLQWLKGIGW-MTSGSLEDEKNK----RATQILSDHVYRQHPDQFK- 2698 Query: 73 IHNTPLDMMSIVQAKKCQVLVSDIDYRNYLHQWT-------CLPDQNDVIQAKKAYDLQS 125 ++ +D + +V AK + ++ +R Y W +PD +V+ AK+ S Sbjct: 2699 -FSSLMDSIPMVLAKNNAITMN---HRLYTEAWDKDKTTVHIMPDTPEVLLAKQNKVNYS 2754 Query: 126 DNLYKSDLEWLKGIGW-LPEGSVEVMRVKNAQNLLNERLYR 165 + LYK LE K G+ + ++ + K ++++ +E Y+ Sbjct: 2755 EKLYKLGLEEAKRKGYDMRVDAIPIKAAKASRDIASEFKYK 2795 Score = 30.0 bits (66), Expect = 1.8 Identities = 31/138 (22%), Positives = 59/138 (42%), Gaps = 5/138 (3%) Query: 63 YKKAYEKSKGIHNTPLDMMSIVQAKKCQVLVSDIDYRNYLHQWTCLPDQNDVIQAKKAYD 122 YK+ K+ TP + + K+ Q +S + Y+ L + T P ++ + K+ + Sbjct: 6309 YKENVGKATATPVTP----EMQRVKRNQENISSVLYKENLGKATPTPFTPEMERVKRNQE 6364 Query: 123 LQSDNLYKSDLEWLKGIGWLPEGSVEVMRVKNAQNLLNERLYRIKPEALKFTSIVDTPEV 182 S LYK ++ PE +N ++L +R + + K ++DTPE+ Sbjct: 6365 NFSSVLYKENMRKATPTPVTPEMERAKRNQENISSVLYSDSFRKQIQG-KAAYVLDTPEM 6423 Query: 183 IQAKINAVQISEVEKSRD 200 + + IS V+ D Sbjct: 6424 RRVRETQRHISTVKYHED 6441 >gi|46049092 nebulin-related anchoring protein isoform C [Homo sapiens] Length = 1695 Score = 159 bits (401), Expect = 3e-39 Identities = 77/184 (41%), Positives = 118/184 (64%) Query: 24 KYKEGYRKQLGHHMGFRTLQDDPKSVWAIHAAKIQSDREYKKAYEKSKGIHNTPLDMMSI 83 KYKE Y + G +G + +Q D + ++ +K+QS+ EYKK +E +K + LDM+ + Sbjct: 786 KYKEDYERSRGKLIGAKDVQGDSQMSHSLQMSKLQSELEYKKGFEDTKSQCHVSLDMVHL 845 Query: 84 VQAKKCQVLVSDIDYRNYLHQWTCLPDQNDVIQAKKAYDLQSDNLYKSDLEWLKGIGWLP 143 V A+K Q L +D+ Y+ H +T LP V AKKAY LQSDN Y++D++W+KG+GW+ Sbjct: 846 VHARKAQHLATDVGYKTAEHHFTALPTDMKVEWAKKAYGLQSDNQYRADVKWMKGMGWVA 905 Query: 144 EGSVEVMRVKNAQNLLNERLYRIKPEALKFTSIVDTPEVIQAKINAVQISEVEKSRDNFN 203 GS+ V + K A L++E+ YR P+ALKFTSI DTPE++QA+I+ Q + N Sbjct: 906 TGSLNVEQAKKAGELISEKKYRQHPDALKFTSIKDTPEMVQARISYTQAVDRLYREQGEN 965 Query: 204 VRHY 207 ++H+ Sbjct: 966 IKHH 969 Score = 145 bits (365), Expect = 4e-35 Identities = 74/163 (45%), Positives = 106/163 (65%), Gaps = 4/163 (2%) Query: 24 KYKEGYRKQLGHHMGFRTLQDDPKSVWAIHAAKIQSDREYKKAYEKSKGIHNTPLDMMSI 83 KYKE Y K G MG D + + ++ AK+ S+ EYKK +E+SK + P+DM++I Sbjct: 547 KYKEEYEKTKGKAMGTA----DSRLLHSLQIAKMSSEVEYKKGFEESKTRFHLPMDMVNI 602 Query: 84 VQAKKCQVLVSDIDYRNYLHQWTCLPDQNDVIQAKKAYDLQSDNLYKSDLEWLKGIGWLP 143 AKK Q L SD+DYR LH++T LP+ AKKAY LQS+ YK+DL W+KG+GWL Sbjct: 603 RHAKKAQTLASDLDYRKKLHEYTVLPEDMKTQWAKKAYGLQSELQYKADLAWMKGVGWLT 662 Query: 144 EGSVEVMRVKNAQNLLNERLYRIKPEALKFTSIVDTPEVIQAK 186 EGS+ + + K A L++E+ YR + + LKFTS+ D+ ++ AK Sbjct: 663 EGSLNLEQAKKAGQLVSEKNYRQRVDELKFTSVTDSSQMEHAK 705 Score = 142 bits (359), Expect = 2e-34 Identities = 69/169 (40%), Positives = 108/169 (63%) Query: 20 VPSYKYKEGYRKQLGHHMGFRTLQDDPKSVWAIHAAKIQSDREYKKAYEKSKGIHNTPLD 79 + YKYKE + K G +G R+L+DD +++A +QSD YKK +E SK + PLD Sbjct: 1025 ISDYKYKEAFEKMKGQMLGSRSLEDDISLAHSVYATSLQSDVNYKKGFEHSKAQFHLPLD 1084 Query: 80 MMSIVQAKKCQVLVSDIDYRNYLHQWTCLPDQNDVIQAKKAYDLQSDNLYKSDLEWLKGI 139 M ++V AKK Q L S+ DY++ L Q+T L + + AKKA+ LQS+NLY+SDL +++G+ Sbjct: 1085 MAALVHAKKAQTLASNQDYKHPLPQYTSLAEDLRLSCAKKAHKLQSENLYRSDLNFMRGV 1144 Query: 140 GWLPEGSVEVMRVKNAQNLLNERLYRIKPEALKFTSIVDTPEVIQAKIN 188 + G++E+ K A L++E YR P + K+T++ DTP ++ AK + Sbjct: 1145 ACVIPGTLEIEGRKKASELISESKYRQHPHSFKYTAVTDTPNLLHAKFS 1193 Score = 130 bits (327), Expect = 1e-30 Identities = 67/186 (36%), Positives = 115/186 (61%), Gaps = 1/186 (0%) Query: 23 YKYKEGYRKQLGHHMGFRTLQDDPKSVWAIHAAKIQSDREYKKAYEKSKGIHNTPLDMMS 82 + Y+ + K+ G +G ++++DDP+ ++QS+ +Y++ S+ + P+DM+ Sbjct: 1271 FLYRHDFVKERGKLIGPQSVRDDPRIQHCRRMGQLQSELQYRRGATSSQAQFHLPMDMVH 1330 Query: 83 IVQAKKCQVLVSDIDYRNYLHQWTCLPDQNDVIQAKKAYDLQSDNLYKSDLEWLKGIGWL 142 +V AK Q L SD DYR H++T LP+ + AKKA+ LQS+ YKSDL +KGIGWL Sbjct: 1331 LVHAKNAQALASDHDYRTQYHKFTALPEDLKMAWAKKAHALQSELRYKSDLIGMKGIGWL 1390 Query: 143 PEGSVEVMRVKNAQNLLNERLYRIKPEALKFTSIVDTPEVIQAKINAVQISE-VEKSRDN 201 S ++ K A L++E YR KP+++KFT++VD+P+++ AK + + +E + +S D Sbjct: 1391 ALRSPQMESAKKAGELISETKYRKKPDSIKFTTVVDSPDLVHAKNSYMHCNERMYRSGDA 1450 Query: 202 FNVRHY 207 ++ Y Sbjct: 1451 ESLHRY 1456 Score = 118 bits (296), Expect = 4e-27 Identities = 61/163 (37%), Positives = 92/163 (56%), Gaps = 12/163 (7%) Query: 12 TYDLSLPEVP------------SYKYKEGYRKQLGHHMGFRTLQDDPKSVWAIHAAKIQS 59 +YD L +P ++YKE + + G +G+R++ DDP+ ++ ++QS Sbjct: 1491 SYDFRLDAIPFQTARASREIASDFRYKEAFLRDRGLQIGYRSVDDDPRMKHFLNVGRLQS 1550 Query: 60 DREYKKAYEKSKGIHNTPLDMMSIVQAKKCQVLVSDIDYRNYLHQWTCLPDQNDVIQAKK 119 D EYKK + KS+ ++ D ++QAK+ Q L SD+ YR L Q TC P+Q + A+K Sbjct: 1551 DNEYKKDFAKSRSQFHSSTDQPGLLQAKRSQQLASDVHYRQPLPQPTCDPEQLGLRHAQK 1610 Query: 120 AYDLQSDNLYKSDLEWLKGIGWLPEGSVEVMRVKNAQNLLNER 162 A+ LQSD YKSDL +G+GW P GS +V + A L N R Sbjct: 1611 AHQLQSDVKYKSDLNLTRGVGWTPPGSYKVEMARRAAELANAR 1653 Score = 56.6 bits (135), Expect = 2e-08 Identities = 54/190 (28%), Positives = 90/190 (47%), Gaps = 15/190 (7%) Query: 24 KYKEGYRKQLGHHMGFRTLQD--DPKSVWAIHAAKIQSDREYKKAYEKSKGI---HNTPL 78 +Y +GY ++ H G + P A A ++ SD +Y++ + K KG H+ P Sbjct: 293 QYGQGYPEEYEEHRGKGSFPAMITPAYQNAKKAHELASDIKYRQDFNKMKGAAHYHSLPA 352 Query: 79 -DMMSIVQAKKCQVLVSDIDYR-NYLH----QWTCLPDQNDVIQAKKAYDLQSDNLYKSD 132 D + + QA+ LVS+ Y+ NY + ++ + + A K L S+ YK+D Sbjct: 353 QDNLVLKQAQSVNKLVSENKYKENYQNHMRGRYEGVGMDRRTLHAMKVGSLASNVAYKAD 412 Query: 133 LEWLKGIGWLPEGSVEVMRVKNAQNL--LNERLYRIKPEALKFTSIVDTPEVIQAKINAV 190 + I + + A L L + YR + LK++S+ DTP+++QAKINA Sbjct: 413 YK--HDIVDYNYPATLTPSYQTAMKLVPLKDANYRQSIDKLKYSSVTDTPQIVQAKINAQ 470 Query: 191 QISEVEKSRD 200 Q+S V D Sbjct: 471 QLSHVNYRAD 480 Score = 45.4 bits (106), Expect = 4e-05 Identities = 46/175 (26%), Positives = 75/175 (42%), Gaps = 41/175 (23%) Query: 29 YRKQLGHHMGFRTLQDDPKSVWAIHAAKIQSDREYKKAYEKSKGIHNTPLDMMSIVQAKK 88 YRK+L + L +D K+ WA A +QS+ +YK KG+ +++ QAKK Sbjct: 617 YRKKLHE---YTVLPEDMKTQWAKKAYGLQSELQYKADLAWMKGVGWLTEGSLNLEQAKK 673 Query: 89 CQVLVSDIDYRNYLHQ--WTCLPDQNDVIQAKKAYDLQS--------------------- 125 LVS+ +YR + + +T + D + + AKK+ +LQS Sbjct: 674 AGQLVSEKNYRQRVDELKFTSVTDSSQMEHAKKSQELQSGVAYKAGNEQSVHQYTISKDE 733 Query: 126 --------------DNLYKSDLEWLKGIGW-LPEGSVEVMRVKNAQNLLNERLYR 165 + LYKS E K G+ L S+ + K ++L +E Y+ Sbjct: 734 PLFLQARANAANLSEKLYKSSWENQKAKGFELRLDSLTFLAAKAKRDLASEVKYK 788 Score = 40.4 bits (93), Expect = 0.001 Identities = 34/132 (25%), Positives = 62/132 (46%), Gaps = 8/132 (6%) Query: 12 TYDLSLPEVPSYKYKEGYRKQLGHHMGFRTLQDDPKSVWAIHAAKIQSDREYKKAYEKSK 71 +Y ++ VP K+ +Q + + ++ D P+ V A A+ S Y+ YEK+K Sbjct: 429 SYQTAMKLVP---LKDANYRQSIDKLKYSSVTDTPQIVQAKINAQQLSHVNYRADYEKNK 485 Query: 72 GIHNTPLDMMSIVQAKKCQVLVSDIDYRNYLHQ-----WTCLPDQNDVIQAKKAYDLQSD 126 + P D+ +V+AK L S++ Y+ + + D ++ AK + +L S+ Sbjct: 486 LNYTLPQDVPQLVKAKTNAKLFSEVKYKEGWEKTKGKGFEMKLDAMSLLAAKASGELASN 545 Query: 127 NLYKSDLEWLKG 138 YK + E KG Sbjct: 546 IKYKEEYEKTKG 557 Score = 38.9 bits (89), Expect = 0.004 Identities = 55/242 (22%), Positives = 94/242 (38%), Gaps = 45/242 (18%) Query: 10 PHTYDLSLPEVPSYKYKEGYRKQLGHHMGFRTLQDDPKSVWAIHAAKIQSDREYKKAYEK 69 P T ++ + S E +Q H + + D P + A + +I ++R YK A E Sbjct: 1149 PGTLEIEGRKKASELISESKYRQHPHSFKYTAVTDTPNLLHAKFSNQITNERLYKAAGED 1208 Query: 70 SKGIHNTPLDMMSIVQAKKCQVLVSDIDY----RNYLHQWTCLPDQNDVIQAKKAY-DLQ 124 ++ + L + ++AK +SD Y RN Q L + QA +A D+ Sbjct: 1209 ARHEYTMTLGLPEFIRAKTNAANLSDARYKESWRNLRAQGYKLTIEALPFQAARASGDIA 1268 Query: 125 SDNLYK--------------------------------SDLEWLKGIG------WLPEGS 146 SD LY+ S+L++ +G LP Sbjct: 1269 SDFLYRHDFVKERGKLIGPQSVRDDPRIQHCRRMGQLQSELQYRRGATSSQAQFHLPMDM 1328 Query: 147 VEVMRVKNAQNLLNERLYRIKPEALKFTSIVDTPEVIQAKINAVQISEVEKSRDNFNVRH 206 V ++ KNAQ L ++ YR + KFT++ + ++ AK SE+ D ++ Sbjct: 1329 VHLVHAKNAQALASDHDYRTQYH--KFTALPEDLKMAWAKKAHALQSELRYKSDLIGMKG 1386 Query: 207 YG 208 G Sbjct: 1387 IG 1388 Score = 38.1 bits (87), Expect = 0.007 Identities = 42/180 (23%), Positives = 72/180 (40%), Gaps = 39/180 (21%) Query: 20 VPSYKYKEGYRKQL-GHHMGFRTLQDDPKSVWAIHAAKIQSDREYKKAYEKSKGIHNTPL 78 V KYKE Y+ + G + G D +++ A+ + S+ YK Y+ +N P Sbjct: 368 VSENKYKENYQNHMRGRYEGVGM---DRRTLHAMKVGSLASNVAYKADYKHDIVDYNYPA 424 Query: 79 DMMSIVQAKKCQVLVSDIDYRNYLHQ--WTCLPDQNDVIQAKKAYDLQSDNLYKSDLEWL 136 + Q V + D +YR + + ++ + D ++QAK S Y++D E Sbjct: 425 TLTPSYQTAMKLVPLKDANYRQSIDKLKYSSVTDTPQIVQAKINAQQLSHVNYRADYE-- 482 Query: 137 KGIGWLPEGSVEVMRVKNAQNLLNERLYRIKPEALKFTSIVDTPEVIQAKINAVQISEVE 196 +N LN +T D P++++AK NA SEV+ Sbjct: 483 -------------------KNKLN------------YTLPQDVPQLVKAKTNAKLFSEVK 511 Score = 37.7 bits (86), Expect = 0.009 Identities = 23/76 (30%), Positives = 41/76 (53%), Gaps = 4/76 (5%) Query: 24 KYKEGYRKQLGHHMGFRTLQDDPKSVWAIHAAKIQSDREYKKAYEKSKGIHNTPLDMMSI 83 +YK G+ +++ F T+ D P+ + + A++QSD Y + YE+ +G + P + Sbjct: 192 EYKRGHDERISR---FSTVVDTPELLRSKAGAQLQSDVRYTEDYEQQRGKGSFPAMITPA 248 Query: 84 VQ-AKKCQVLVSDIDY 98 Q AK+ L SD+ Y Sbjct: 249 YQIAKRANELASDVRY 264 Score = 37.0 bits (84), Expect = 0.015 Identities = 36/149 (24%), Positives = 52/149 (34%), Gaps = 44/149 (29%) Query: 23 YKYKEGYRKQLGHHMGFRTLQDDPKSVWAIHAAKIQSDREYKKAYEKSKGIHNTPLDMMS 82 + Y+ Y K F L +D K WA A +QS+ YK KGI L Sbjct: 1344 HDYRTQYHK-------FTALPEDLKMAWAKKAHALQSELRYKSDLIGMKGIGWLALRSPQ 1396 Query: 83 IVQAKKCQVLVSDIDYRNY-------------------------------------LHQW 105 + AKK L+S+ YR LH++ Sbjct: 1397 MESAKKAGELISETKYRKKPDSIKFTTVVDSPDLVHAKNSYMHCNERMYRSGDAESLHRY 1456 Query: 106 TCLPDQNDVIQAKKAYDLQSDNLYKSDLE 134 T +PD D +A+ SD +Y++ E Sbjct: 1457 TLIPDHPDFTRARLNALHLSDKVYRNSWE 1485 Score = 35.4 bits (80), Expect = 0.043 Identities = 31/108 (28%), Positives = 52/108 (48%), Gaps = 9/108 (8%) Query: 108 LPDQNDV--IQAKKAYDLQSDNLYKSDLEWLKGIGWLPEGSVEV-MRVKNAQNLLNERLY 164 LPD V ++A+K+ + Y D E +G G P R K A L ++ Y Sbjct: 138 LPDPEIVRMVEARKSLGEE----YTEDYEQPRGKGSFPAMITPAYQRAKKANQLASQVEY 193 Query: 165 RIKPEAL--KFTSIVDTPEVIQAKINAVQISEVEKSRDNFNVRHYGSY 210 + + +F+++VDTPE++++K A S+V + D R GS+ Sbjct: 194 KRGHDERISRFSTVVDTPELLRSKAGAQLQSDVRYTEDYEQQRGKGSF 241 Score = 31.2 bits (69), Expect = 0.82 Identities = 32/119 (26%), Positives = 58/119 (48%), Gaps = 9/119 (7%) Query: 60 DREYKKAYEKSKGIHNTPLDMMSIVQAKKCQVLVSDIDYR-----NYLHQWTCLPDQNDV 114 D Y+++ +K K +++ D IVQAK +S ++YR N L+ +T D + Sbjct: 441 DANYRQSIDKLK--YSSVTDTPQIVQAKINAQQLSHVNYRADYEKNKLN-YTLPQDVPQL 497 Query: 115 IQAKKAYDLQSDNLYKSDLEWLKGIGW-LPEGSVEVMRVKNAQNLLNERLYRIKPEALK 172 ++AK L S+ YK E KG G+ + ++ ++ K + L + Y+ + E K Sbjct: 498 VKAKTNAKLFSEVKYKEGWEKTKGKGFEMKLDAMSLLAAKASGELASNIKYKEEYEKTK 556 >gi|46049105 nebulin-related anchoring protein isoform S [Homo sapiens] Length = 1730 Score = 159 bits (401), Expect = 3e-39 Identities = 77/184 (41%), Positives = 118/184 (64%) Query: 24 KYKEGYRKQLGHHMGFRTLQDDPKSVWAIHAAKIQSDREYKKAYEKSKGIHNTPLDMMSI 83 KYKE Y + G +G + +Q D + ++ +K+QS+ EYKK +E +K + LDM+ + Sbjct: 821 KYKEDYERSRGKLIGAKDVQGDSQMSHSLQMSKLQSELEYKKGFEDTKSQCHVSLDMVHL 880 Query: 84 VQAKKCQVLVSDIDYRNYLHQWTCLPDQNDVIQAKKAYDLQSDNLYKSDLEWLKGIGWLP 143 V A+K Q L +D+ Y+ H +T LP V AKKAY LQSDN Y++D++W+KG+GW+ Sbjct: 881 VHARKAQHLATDVGYKTAEHHFTALPTDMKVEWAKKAYGLQSDNQYRADVKWMKGMGWVA 940 Query: 144 EGSVEVMRVKNAQNLLNERLYRIKPEALKFTSIVDTPEVIQAKINAVQISEVEKSRDNFN 203 GS+ V + K A L++E+ YR P+ALKFTSI DTPE++QA+I+ Q + N Sbjct: 941 TGSLNVEQAKKAGELISEKKYRQHPDALKFTSIKDTPEMVQARISYTQAVDRLYREQGEN 1000 Query: 204 VRHY 207 ++H+ Sbjct: 1001 IKHH 1004 Score = 145 bits (365), Expect = 4e-35 Identities = 74/163 (45%), Positives = 106/163 (65%), Gaps = 4/163 (2%) Query: 24 KYKEGYRKQLGHHMGFRTLQDDPKSVWAIHAAKIQSDREYKKAYEKSKGIHNTPLDMMSI 83 KYKE Y K G MG D + + ++ AK+ S+ EYKK +E+SK + P+DM++I Sbjct: 582 KYKEEYEKTKGKAMGTA----DSRLLHSLQIAKMSSEVEYKKGFEESKTRFHLPMDMVNI 637 Query: 84 VQAKKCQVLVSDIDYRNYLHQWTCLPDQNDVIQAKKAYDLQSDNLYKSDLEWLKGIGWLP 143 AKK Q L SD+DYR LH++T LP+ AKKAY LQS+ YK+DL W+KG+GWL Sbjct: 638 RHAKKAQTLASDLDYRKKLHEYTVLPEDMKTQWAKKAYGLQSELQYKADLAWMKGVGWLT 697 Query: 144 EGSVEVMRVKNAQNLLNERLYRIKPEALKFTSIVDTPEVIQAK 186 EGS+ + + K A L++E+ YR + + LKFTS+ D+ ++ AK Sbjct: 698 EGSLNLEQAKKAGQLVSEKNYRQRVDELKFTSVTDSSQMEHAK 740 Score = 142 bits (359), Expect = 2e-34 Identities = 69/169 (40%), Positives = 108/169 (63%) Query: 20 VPSYKYKEGYRKQLGHHMGFRTLQDDPKSVWAIHAAKIQSDREYKKAYEKSKGIHNTPLD 79 + YKYKE + K G +G R+L+DD +++A +QSD YKK +E SK + PLD Sbjct: 1060 ISDYKYKEAFEKMKGQMLGSRSLEDDISLAHSVYATSLQSDVNYKKGFEHSKAQFHLPLD 1119 Query: 80 MMSIVQAKKCQVLVSDIDYRNYLHQWTCLPDQNDVIQAKKAYDLQSDNLYKSDLEWLKGI 139 M ++V AKK Q L S+ DY++ L Q+T L + + AKKA+ LQS+NLY+SDL +++G+ Sbjct: 1120 MAALVHAKKAQTLASNQDYKHPLPQYTSLAEDLRLSCAKKAHKLQSENLYRSDLNFMRGV 1179 Query: 140 GWLPEGSVEVMRVKNAQNLLNERLYRIKPEALKFTSIVDTPEVIQAKIN 188 + G++E+ K A L++E YR P + K+T++ DTP ++ AK + Sbjct: 1180 ACVIPGTLEIEGRKKASELISESKYRQHPHSFKYTAVTDTPNLLHAKFS 1228 Score = 130 bits (327), Expect = 1e-30 Identities = 67/186 (36%), Positives = 115/186 (61%), Gaps = 1/186 (0%) Query: 23 YKYKEGYRKQLGHHMGFRTLQDDPKSVWAIHAAKIQSDREYKKAYEKSKGIHNTPLDMMS 82 + Y+ + K+ G +G ++++DDP+ ++QS+ +Y++ S+ + P+DM+ Sbjct: 1306 FLYRHDFVKERGKLIGPQSVRDDPRIQHCRRMGQLQSELQYRRGATSSQAQFHLPMDMVH 1365 Query: 83 IVQAKKCQVLVSDIDYRNYLHQWTCLPDQNDVIQAKKAYDLQSDNLYKSDLEWLKGIGWL 142 +V AK Q L SD DYR H++T LP+ + AKKA+ LQS+ YKSDL +KGIGWL Sbjct: 1366 LVHAKNAQALASDHDYRTQYHKFTALPEDLKMAWAKKAHALQSELRYKSDLIGMKGIGWL 1425 Query: 143 PEGSVEVMRVKNAQNLLNERLYRIKPEALKFTSIVDTPEVIQAKINAVQISE-VEKSRDN 201 S ++ K A L++E YR KP+++KFT++VD+P+++ AK + + +E + +S D Sbjct: 1426 ALRSPQMESAKKAGELISETKYRKKPDSIKFTTVVDSPDLVHAKNSYMHCNERMYRSGDA 1485 Query: 202 FNVRHY 207 ++ Y Sbjct: 1486 ESLHRY 1491 Score = 118 bits (296), Expect = 4e-27 Identities = 61/163 (37%), Positives = 92/163 (56%), Gaps = 12/163 (7%) Query: 12 TYDLSLPEVP------------SYKYKEGYRKQLGHHMGFRTLQDDPKSVWAIHAAKIQS 59 +YD L +P ++YKE + + G +G+R++ DDP+ ++ ++QS Sbjct: 1526 SYDFRLDAIPFQTARASREIASDFRYKEAFLRDRGLQIGYRSVDDDPRMKHFLNVGRLQS 1585 Query: 60 DREYKKAYEKSKGIHNTPLDMMSIVQAKKCQVLVSDIDYRNYLHQWTCLPDQNDVIQAKK 119 D EYKK + KS+ ++ D ++QAK+ Q L SD+ YR L Q TC P+Q + A+K Sbjct: 1586 DNEYKKDFAKSRSQFHSSTDQPGLLQAKRSQQLASDVHYRQPLPQPTCDPEQLGLRHAQK 1645 Query: 120 AYDLQSDNLYKSDLEWLKGIGWLPEGSVEVMRVKNAQNLLNER 162 A+ LQSD YKSDL +G+GW P GS +V + A L N R Sbjct: 1646 AHQLQSDVKYKSDLNLTRGVGWTPPGSYKVEMARRAAELANAR 1688 Score = 53.9 bits (128), Expect = 1e-07 Identities = 52/185 (28%), Positives = 80/185 (43%), Gaps = 10/185 (5%) Query: 24 KYKEGYRKQLGH-HMGFRTLQDDPKSVWAIHAAKIQSDREYKKAYEKSKGIHNTPLDMMS 82 KY++ + K G H QD+ A K+ S+ EYKK E S+G + Sbjct: 333 KYRQDFNKMKGAAHYHSLPAQDNLVLKQAQSVNKLVSEVEYKKDLESSRGHSINYCETPQ 392 Query: 83 IVQAKKCQVLVSDIDYR-NYLH----QWTCLPDQNDVIQAKKAYDLQSDNLYKSDLEWLK 137 K SD Y+ NY + ++ + + A K L S+ YK+D + Sbjct: 393 FRNVSKISKFTSDNKYKENYQNHMRGRYEGVGMDRRTLHAMKVGSLASNVAYKADYK--H 450 Query: 138 GIGWLPEGSVEVMRVKNAQNL--LNERLYRIKPEALKFTSIVDTPEVIQAKINAVQISEV 195 I + + A L L + YR + LK++S+ DTP+++QAKINA Q+S V Sbjct: 451 DIVDYNYPATLTPSYQTAMKLVPLKDANYRQSIDKLKYSSVTDTPQIVQAKINAQQLSHV 510 Query: 196 EKSRD 200 D Sbjct: 511 NYRAD 515 Score = 45.4 bits (106), Expect = 4e-05 Identities = 46/175 (26%), Positives = 75/175 (42%), Gaps = 41/175 (23%) Query: 29 YRKQLGHHMGFRTLQDDPKSVWAIHAAKIQSDREYKKAYEKSKGIHNTPLDMMSIVQAKK 88 YRK+L + L +D K+ WA A +QS+ +YK KG+ +++ QAKK Sbjct: 652 YRKKLHE---YTVLPEDMKTQWAKKAYGLQSELQYKADLAWMKGVGWLTEGSLNLEQAKK 708 Query: 89 CQVLVSDIDYRNYLHQ--WTCLPDQNDVIQAKKAYDLQS--------------------- 125 LVS+ +YR + + +T + D + + AKK+ +LQS Sbjct: 709 AGQLVSEKNYRQRVDELKFTSVTDSSQMEHAKKSQELQSGVAYKAGNEQSVHQYTISKDE 768 Query: 126 --------------DNLYKSDLEWLKGIGW-LPEGSVEVMRVKNAQNLLNERLYR 165 + LYKS E K G+ L S+ + K ++L +E Y+ Sbjct: 769 PLFLQARANAANLSEKLYKSSWENQKAKGFELRLDSLTFLAAKAKRDLASEVKYK 823 Score = 40.4 bits (93), Expect = 0.001 Identities = 34/132 (25%), Positives = 62/132 (46%), Gaps = 8/132 (6%) Query: 12 TYDLSLPEVPSYKYKEGYRKQLGHHMGFRTLQDDPKSVWAIHAAKIQSDREYKKAYEKSK 71 +Y ++ VP K+ +Q + + ++ D P+ V A A+ S Y+ YEK+K Sbjct: 464 SYQTAMKLVP---LKDANYRQSIDKLKYSSVTDTPQIVQAKINAQQLSHVNYRADYEKNK 520 Query: 72 GIHNTPLDMMSIVQAKKCQVLVSDIDYRNYLHQ-----WTCLPDQNDVIQAKKAYDLQSD 126 + P D+ +V+AK L S++ Y+ + + D ++ AK + +L S+ Sbjct: 521 LNYTLPQDVPQLVKAKTNAKLFSEVKYKEGWEKTKGKGFEMKLDAMSLLAAKASGELASN 580 Query: 127 NLYKSDLEWLKG 138 YK + E KG Sbjct: 581 IKYKEEYEKTKG 592 Score = 38.9 bits (89), Expect = 0.004 Identities = 55/242 (22%), Positives = 94/242 (38%), Gaps = 45/242 (18%) Query: 10 PHTYDLSLPEVPSYKYKEGYRKQLGHHMGFRTLQDDPKSVWAIHAAKIQSDREYKKAYEK 69 P T ++ + S E +Q H + + D P + A + +I ++R YK A E Sbjct: 1184 PGTLEIEGRKKASELISESKYRQHPHSFKYTAVTDTPNLLHAKFSNQITNERLYKAAGED 1243 Query: 70 SKGIHNTPLDMMSIVQAKKCQVLVSDIDY----RNYLHQWTCLPDQNDVIQAKKAY-DLQ 124 ++ + L + ++AK +SD Y RN Q L + QA +A D+ Sbjct: 1244 ARHEYTMTLGLPEFIRAKTNAANLSDARYKESWRNLRAQGYKLTIEALPFQAARASGDIA 1303 Query: 125 SDNLYK--------------------------------SDLEWLKGIG------WLPEGS 146 SD LY+ S+L++ +G LP Sbjct: 1304 SDFLYRHDFVKERGKLIGPQSVRDDPRIQHCRRMGQLQSELQYRRGATSSQAQFHLPMDM 1363 Query: 147 VEVMRVKNAQNLLNERLYRIKPEALKFTSIVDTPEVIQAKINAVQISEVEKSRDNFNVRH 206 V ++ KNAQ L ++ YR + KFT++ + ++ AK SE+ D ++ Sbjct: 1364 VHLVHAKNAQALASDHDYRTQYH--KFTALPEDLKMAWAKKAHALQSELRYKSDLIGMKG 1421 Query: 207 YG 208 G Sbjct: 1422 IG 1423 Score = 37.7 bits (86), Expect = 0.009 Identities = 52/234 (22%), Positives = 102/234 (43%), Gaps = 52/234 (22%) Query: 24 KYKEGYRKQLGHHMGFRTLQDDPKSVWAIHAAKIQSDREYKKAYEKSKGIHNTPLDMMSI 83 +YK G+ +++ F T+ D P+ + + A++QSD Y + YE+ +G + P + Sbjct: 192 EYKRGHDERISR---FSTVVDTPELLRSKAGAQLQSDVRYTEDYEQQRGKGSFPAMITPA 248 Query: 84 VQ-AKKCQVLVSDIDY-RNYLHQWTCL-----------------------PDQNDVIQ-- 116 Q AK+ L SD+ Y + Y + + P++ + + Sbjct: 249 YQIAKRANELASDVRYHQQYQKEMRGMAGPAIGAEGILTRECADQYGQGYPEEYEEHRGK 308 Query: 117 -------------AKKAYDLQSDNLYKSDLEWLKGIGW---LP-EGSVEVMRVKNAQNLL 159 AKKA++L SD Y+ D +KG LP + ++ + + ++ L+ Sbjct: 309 GSFPAMITPAYQNAKKAHELASDIKYRQDFNKMKGAAHYHSLPAQDNLVLKQAQSVNKLV 368 Query: 160 NERLYRIKPEALKFTSI--VDTPEVIQ-AKINAVQISEVEKSRDNFNVRHYGSY 210 +E Y+ E+ + SI +TP+ +KI+ + + K ++N+ G Y Sbjct: 369 SEVEYKKDLESSRGHSINYCETPQFRNVSKIS--KFTSDNKYKENYQNHMRGRY 420 Score = 37.7 bits (86), Expect = 0.009 Identities = 41/176 (23%), Positives = 71/176 (40%), Gaps = 39/176 (22%) Query: 24 KYKEGYRKQL-GHHMGFRTLQDDPKSVWAIHAAKIQSDREYKKAYEKSKGIHNTPLDMMS 82 KYKE Y+ + G + G D +++ A+ + S+ YK Y+ +N P + Sbjct: 407 KYKENYQNHMRGRYEGVGM---DRRTLHAMKVGSLASNVAYKADYKHDIVDYNYPATLTP 463 Query: 83 IVQAKKCQVLVSDIDYRNYLHQ--WTCLPDQNDVIQAKKAYDLQSDNLYKSDLEWLKGIG 140 Q V + D +YR + + ++ + D ++QAK S Y++D E Sbjct: 464 SYQTAMKLVPLKDANYRQSIDKLKYSSVTDTPQIVQAKINAQQLSHVNYRADYE------ 517 Query: 141 WLPEGSVEVMRVKNAQNLLNERLYRIKPEALKFTSIVDTPEVIQAKINAVQISEVE 196 +N LN +T D P++++AK NA SEV+ Sbjct: 518 ---------------KNKLN------------YTLPQDVPQLVKAKTNAKLFSEVK 546 Score = 37.0 bits (84), Expect = 0.015 Identities = 36/149 (24%), Positives = 52/149 (34%), Gaps = 44/149 (29%) Query: 23 YKYKEGYRKQLGHHMGFRTLQDDPKSVWAIHAAKIQSDREYKKAYEKSKGIHNTPLDMMS 82 + Y+ Y K F L +D K WA A +QS+ YK KGI L Sbjct: 1379 HDYRTQYHK-------FTALPEDLKMAWAKKAHALQSELRYKSDLIGMKGIGWLALRSPQ 1431 Query: 83 IVQAKKCQVLVSDIDYRNY-------------------------------------LHQW 105 + AKK L+S+ YR LH++ Sbjct: 1432 MESAKKAGELISETKYRKKPDSIKFTTVVDSPDLVHAKNSYMHCNERMYRSGDAESLHRY 1491 Query: 106 TCLPDQNDVIQAKKAYDLQSDNLYKSDLE 134 T +PD D +A+ SD +Y++ E Sbjct: 1492 TLIPDHPDFTRARLNALHLSDKVYRNSWE 1520 Score = 35.4 bits (80), Expect = 0.043 Identities = 31/108 (28%), Positives = 52/108 (48%), Gaps = 9/108 (8%) Query: 108 LPDQNDV--IQAKKAYDLQSDNLYKSDLEWLKGIGWLPEGSVEV-MRVKNAQNLLNERLY 164 LPD V ++A+K+ + Y D E +G G P R K A L ++ Y Sbjct: 138 LPDPEIVRMVEARKSLGEE----YTEDYEQPRGKGSFPAMITPAYQRAKKANQLASQVEY 193 Query: 165 RIKPEAL--KFTSIVDTPEVIQAKINAVQISEVEKSRDNFNVRHYGSY 210 + + +F+++VDTPE++++K A S+V + D R GS+ Sbjct: 194 KRGHDERISRFSTVVDTPELLRSKAGAQLQSDVRYTEDYEQQRGKGSF 241 Score = 31.2 bits (69), Expect = 0.82 Identities = 32/119 (26%), Positives = 58/119 (48%), Gaps = 9/119 (7%) Query: 60 DREYKKAYEKSKGIHNTPLDMMSIVQAKKCQVLVSDIDYR-----NYLHQWTCLPDQNDV 114 D Y+++ +K K +++ D IVQAK +S ++YR N L+ +T D + Sbjct: 476 DANYRQSIDKLK--YSSVTDTPQIVQAKINAQQLSHVNYRADYEKNKLN-YTLPQDVPQL 532 Query: 115 IQAKKAYDLQSDNLYKSDLEWLKGIGW-LPEGSVEVMRVKNAQNLLNERLYRIKPEALK 172 ++AK L S+ YK E KG G+ + ++ ++ K + L + Y+ + E K Sbjct: 533 VKAKTNAKLFSEVKYKEGWEKTKGKGFEMKLDAMSLLAAKASGELASNIKYKEEYEKTK 591 >gi|5453758 nebulette sarcomeric isoform [Homo sapiens] Length = 1014 Score = 62.4 bits (150), Expect = 3e-10 Identities = 49/158 (31%), Positives = 79/158 (50%), Gaps = 14/158 (8%) Query: 51 AIHAAKIQSDREYKKAYE---KSKGIHNTPLDMMSIVQAKKCQVLVSDIDYRNYLHQ--- 104 A A+++ S++EYKK E K KG+ D + + AKK + S+ DY+ L Sbjct: 437 AKRASEMASEKEYKKDLESIIKGKGMQ-AGTDTLEMQHAKKAAEIASEKDYKRDLETEIK 495 Query: 105 ---WTCLPDQNDVIQAKKAYDLQSDNLYKSDLE-WLKGIGWLPEGSV-EVMRVKNAQNLL 159 D DV +AKKA ++ S YK DLE +KG G + +++R K + Sbjct: 496 GKGMQVSTDTLDVQRAKKASEMASQKQYKKDLENEIKGKGMQVSMDIPDILRAKRTSEIY 555 Query: 160 NERLYRIKPEAL--KFTSIVDTPEVIQAKINAVQISEV 195 ++R Y+ + E + +++I DTPE+ + K IS V Sbjct: 556 SQRKYKDEAEKMLSNYSTIADTPEIQRIKTTQQNISAV 593 Score = 55.1 bits (131), Expect = 5e-08 Identities = 46/171 (26%), Positives = 78/171 (45%), Gaps = 9/171 (5%) Query: 29 YRKQLGHHM---GFRTLQDDPKSVWAIHAAKIQSDREYKKAYEKSKGIHNTPLDMMSIVQ 85 Y+K L + + G + D P + A ++I S R+YK EK ++T D I + Sbjct: 523 YKKDLENEIKGKGMQVSMDIPDILRAKRTSEIYSQRKYKDEAEKMLSNYSTIADTPEIQR 582 Query: 86 AKKCQVLVSDIDYRNYLHQWTCLPDQNDVIQAKKAYDLQSDNLYKSDLEWLKGIGWLPEG 145 K Q +S + Y+ + T + D ++ + KK S YK +++ I PE Sbjct: 583 IKTTQQNISAVFYKKEVGAGTAVKDSPEIERVKKNQQNISSVKYKEEIKHATAISDPPE- 641 Query: 146 SVEVMRVKNAQNLLNERLYRIKPEALKFTSIVDTPEVIQAKINAVQISEVE 196 + RVK Q ++ Y K + K T + TPE+ + + N Q+S V+ Sbjct: 642 ---LKRVKENQKNISNLQY--KEQNYKATPVSMTPEIERVRRNQEQLSAVK 687 Score = 53.9 bits (128), Expect = 1e-07 Identities = 46/162 (28%), Positives = 81/162 (50%), Gaps = 15/162 (9%) Query: 52 IHAAKIQSDREYKKAYEKSKGIHNTPLDMMSIVQAKKCQVLVSDIDYRNYLHQWTCLP-- 109 + A+K+ S REYKK +E++KG+++ D + + K VL S + Y+ + P Sbjct: 293 LKASKMLSGREYKKLFEENKGMYHFDADAVEHLHHKGNAVLQSQVKYKEEYEKNKGKPML 352 Query: 110 ---DQNDVIQAKKAYDLQSDNLYKSDLE-WLKGIGWLP-EGSVEVMRVKNAQNLLNERLY 164 + +K+A +QS+ +YK D E +KG L + + E + VK NLL E+ Y Sbjct: 353 EFVETPSYQASKEAQKMQSEKVYKEDFEKEIKGRSSLDLDKTPEFLHVKYITNLLREKEY 412 Query: 165 R------IKPEALKFTSIVDTPEVIQAKINAVQISEVEKSRD 200 + IK + ++ S + ++ +AK + SE E +D Sbjct: 413 KKDLENEIKGKGMELNS--EVLDIQRAKRASEMASEKEYKKD 452 Score = 48.5 bits (114), Expect = 5e-06 Identities = 52/193 (26%), Positives = 91/193 (47%), Gaps = 20/193 (10%) Query: 24 KYKEGYRKQLGHHMGFRTLQDDPKSVWAIHAAKIQSDREYKKAYEKS-KGIHNTPLDMM- 81 KYKE Y K G M + P + A K+QS++ YK+ +EK KG + LD Sbjct: 338 KYKEEYEKNKGKPM--LEFVETPSYQASKEAQKMQSEKVYKEDFEKEIKGRSSLDLDKTP 395 Query: 82 SIVQAKKCQVLVSDIDYRNYLHQ------WTCLPDQNDVIQAKKAYDLQSDNLYKSDLE- 134 + K L+ + +Y+ L + D+ +AK+A ++ S+ YK DLE Sbjct: 396 EFLHVKYITNLLREKEYKKDLENEIKGKGMELNSEVLDIQRAKRASEMASEKEYKKDLES 455 Query: 135 WLKGIGW-LPEGSVEVMRVKNAQNLLNERLYR------IKPEALKFTSIVDTPEVIQAKI 187 +KG G ++E+ K A + +E+ Y+ IK + ++ ++ DT +V +AK Sbjct: 456 IIKGKGMQAGTDTLEMQHAKKAAEIASEKDYKRDLETEIKGKGMQVST--DTLDVQRAKK 513 Query: 188 NAVQISEVEKSRD 200 + S+ + +D Sbjct: 514 ASEMASQKQYKKD 526 Score = 46.2 bits (108), Expect = 2e-05 Identities = 46/172 (26%), Positives = 71/172 (41%), Gaps = 13/172 (7%) Query: 24 KYKEGYRKQLGHHMGFRTLQDDPKSVWAIHAAKIQSDREYKKAYEKSKGIHNTPLDMMSI 83 KYK+ K L + + T+ D P+ I K Y+K G D I Sbjct: 559 KYKDEAEKMLSN---YSTIADTPE----IQRIKTTQQNISAVFYKKEVGAGTAVKDSPEI 611 Query: 84 VQAKKCQVLVSDIDYRNYLHQWTCLPDQNDVIQAKKAYDLQSDNLYKSDLEWLKGIGWLP 143 + KK Q +S + Y+ + T + D ++ + K+ S+ YK + P Sbjct: 612 ERVKKNQQNISSVKYKEEIKHATAISDPPELKRVKENQKNISNLQYKEQNYKATPVSMTP 671 Query: 144 EGSVEVMRVKNAQNLLNERLYRIKPEALKFTSIVDTPEVIQAKINAVQISEV 195 E+ RV+ Q L+ Y K E + T+I D PE+ +AK N IS V Sbjct: 672 ----EIERVRRNQEQLSAVKY--KGELQRGTAISDPPELKRAKENQKNISNV 717 Score = 39.7 bits (91), Expect = 0.002 Identities = 36/136 (26%), Positives = 62/136 (45%), Gaps = 7/136 (5%) Query: 62 EYKKAYEKSKGIHNTPLDMMSIVQAKKCQVLVSDIDYRNYLHQWTCLPDQNDVIQAKKAY 121 +YK ++ I + P + +AK+ Q +S++ YR L + T L ++ + KK Sbjct: 687 KYKGELQRGTAISDPP----ELKRAKENQKNISNVYYRGQLGRATTLSVTPEMERVKKNQ 742 Query: 122 DLQSDNLYKSDLEWLKGIGWLPEGSVEVMRVKNAQNLLNERLYRIKPEALK---FTSIVD 178 + S Y D + +KG L + + VK AQN ++ Y E K FT +VD Sbjct: 743 ENISSVKYTQDHKQMKGRPSLILDTPAMRHVKEAQNHISMVKYHEDFEKTKGRGFTPVVD 802 Query: 179 TPEVIQAKINAVQISE 194 P + + N +S+ Sbjct: 803 DPVTERVRKNTQVVSD 818 Score = 29.3 bits (64), Expect = 3.1 Identities = 48/189 (25%), Positives = 77/189 (40%), Gaps = 14/189 (7%) Query: 19 EVPSYKYKEGYRKQLGHHMGFRTLQDDPKSVWAIHAAKIQSDREYKKA---YEKSKGIHN 75 EV ++ YRK + + D P A +KI S+ EYKK K + Sbjct: 153 EVNKHQSNISYRKDVQDTHTYSAELDRPDIKMATQISKIISNAEYKKGQGIMNKEPAVIG 212 Query: 76 TPLDMMSIVQAKKCQVLVS-----DIDYRNYLHQWTCLPDQNDVIQAKKAYDLQSDNLYK 130 P D V+A K + D + ++ H + L + Q + A L S+ YK Sbjct: 213 RP-DFEHAVEASKLSSQIKYKEKFDNEMKDKKHHYNPL-ESASFRQNQLAATLASNVKYK 270 Query: 131 SDLEWLKG-IGWLPEGSVEVMRVKNAQNLLNERLYRIKPEALK--FTSIVDTPEVIQAKI 187 D++ + + LP + + V A +L+ R Y+ E K + D E + K Sbjct: 271 KDIQNMHDPVSDLP-NLLFLDHVLKASKMLSGREYKKLFEENKGMYHFDADAVEHLHHKG 329 Query: 188 NAVQISEVE 196 NAV S+V+ Sbjct: 330 NAVLQSQVK 338 Score = 28.5 bits (62), Expect = 5.3 Identities = 35/165 (21%), Positives = 70/165 (42%), Gaps = 12/165 (7%) Query: 68 EKSKGIHNTPLDMMSIVQAKKCQVLVSDIDYRNYL----HQWTCLPDQNDVIQAKKAYDL 123 E+ + + ++ +S+ A+KC L+SDI Y+ + T + D + K Sbjct: 24 EEDQVFYKPVIEDLSMELARKCTELISDIRYKEEFKKSKDKCTFVTDSPMLNHVKNIGAF 83 Query: 124 QSDNLYKSDL--EWLKGIGWLPEGSVEVMRVKNAQNLLNERLYRIKPEALK----FTSIV 177 S+ YK + + + +++ + L +E Y+ K +A K + + Sbjct: 84 ISEAKYKGTIKADLSNSLYKRMPATIDSVFAGEVTQLQSEVAYKQKHDAAKGFSDYAHMK 143 Query: 178 DTPEVIQA-KINAVQISEVEKSRDNFNVRHYGSYLDQKQLGPAQQ 221 + PEV A ++N Q S + +D + Y + LD+ + A Q Sbjct: 144 EPPEVKHAMEVNKHQ-SNISYRKDVQDTHTYSAELDRPDIKMATQ 187 Score = 28.1 bits (61), Expect = 6.9 Identities = 23/106 (21%), Positives = 43/106 (40%), Gaps = 6/106 (5%) Query: 39 FRTLQDDPKSVWAIHAAKIQSDREYKKAYEKSKGIHNTPLDMMSIVQAKKCQVLVSDIDY 98 ++ + +D A ++ SD YK+ ++KSK D + K +S+ Y Sbjct: 30 YKPVIEDLSMELARKCTELISDIRYKEEFKKSKDKCTFVTDSPMLNHVKNIGAFISEAKY 89 Query: 99 RNYLHQ------WTCLPDQNDVIQAKKAYDLQSDNLYKSDLEWLKG 138 + + + +P D + A + LQS+ YK + KG Sbjct: 90 KGTIKADLSNSLYKRMPATIDSVFAGEVTQLQSEVAYKQKHDAAKG 135 >gi|47087157 nebulette non-muscle isoform [Homo sapiens] Length = 270 Score = 37.4 bits (85), Expect = 0.011 Identities = 27/94 (28%), Positives = 46/94 (48%), Gaps = 4/94 (4%) Query: 105 WTCLPDQNDVIQAKKAYDLQSDNLYKSDLEWLKGIGW-LPEGSVEVMRVKNAQNLLNERL 163 +T + D + ++ K+ +LQS YK D E KG G+ + + E+ R+K Q ++ Sbjct: 62 FTTVADTPENLRLKQQSELQSQVKYKRDFEESKGRGFSIVTDTPELQRLKRTQEQISNVK 121 Query: 164 YRIKPEALK---FTSIVDTPEVIQAKINAVQISE 194 Y E K FT +VD P + + N +S+ Sbjct: 122 YHEDFEKTKGRGFTPVVDDPVTERVRKNTQVVSD 155 Score = 33.9 bits (76), Expect = 0.13 Identities = 24/98 (24%), Positives = 48/98 (48%), Gaps = 6/98 (6%) Query: 39 FRTLQDDPKSVWAIHAAKIQSDREYKKAYEKSKGI-HNTPLDMMSIVQAKKCQVLVSDID 97 F T+ D P+++ +++QS +YK+ +E+SKG + D + + K+ Q +S++ Sbjct: 62 FTTVADTPENLRLKQQSELQSQVKYKRDFEESKGRGFSIVTDTPELQRLKRTQEQISNVK 121 Query: 98 YRNYLHQ-----WTCLPDQNDVIQAKKAYDLQSDNLYK 130 Y + +T + D + +K + SD YK Sbjct: 122 YHEDFEKTKGRGFTPVVDDPVTERVRKNTQVVSDAAYK 159 Score = 27.7 bits (60), Expect = 9.0 Identities = 18/54 (33%), Positives = 27/54 (50%), Gaps = 6/54 (11%) Query: 153 KNAQNLLNERLYRIKPEA------LKFTSIVDTPEVIQAKINAVQISEVEKSRD 200 K A N+ N + Y KP FT++ DTPE ++ K + S+V+ RD Sbjct: 36 KMALNMNNYKGYEKKPYCNAHYPKQSFTTVADTPENLRLKQQSELQSQVKYKRD 89 >gi|5453710 LIM and SH3 protein 1 [Homo sapiens] Length = 261 Score = 36.6 bits (83), Expect = 0.019 Identities = 30/134 (22%), Positives = 59/134 (44%), Gaps = 3/134 (2%) Query: 2 HLSCLFPKPHTYDLSLPEVPSYKYKEGYRKQLGHHMGFRTLQDDPKSVWAIHAAKIQSDR 61 H +C + L++ Y+ K+ Y F + D P+++ +++QS Sbjct: 26 HKACFHCETCKMTLNMKNYKGYE-KKPYCNAHYPKQSFTMVADTPENLRLKQQSELQSQV 84 Query: 62 EYKKAYEKSKGI-HNTPLDMMSIVQAKKCQVLVSDIDYRNYLHQWTCLPDQNDVIQAKKA 120 YK+ +EK+KG + D + + KK Q +S+I Y + P + ++ ++ Sbjct: 85 RYKEEFEKNKGKGFSVVADTPELQRIKKTQDQISNIKYHEEFEKSRMGPSGGEGMEPERR 144 Query: 121 YDLQSDNLYKSDLE 134 D Q + Y+ LE Sbjct: 145 -DSQDGSSYRRPLE 157 Score = 28.5 bits (62), Expect = 5.3 Identities = 17/61 (27%), Positives = 33/61 (54%), Gaps = 1/61 (1%) Query: 105 WTCLPDQNDVIQAKKAYDLQSDNLYKSDLEWLKGIGW-LPEGSVEVMRVKNAQNLLNERL 163 +T + D + ++ K+ +LQS YK + E KG G+ + + E+ R+K Q+ ++ Sbjct: 62 FTMVADTPENLRLKQQSELQSQVRYKEEFEKNKGKGFSVVADTPELQRIKKTQDQISNIK 121 Query: 164 Y 164 Y Sbjct: 122 Y 122 >gi|127138957 zinc finger protein 537 [Homo sapiens] Length = 1081 Score = 30.4 bits (67), Expect = 1.4 Identities = 22/91 (24%), Positives = 43/91 (47%), Gaps = 6/91 (6%) Query: 147 VEVMRVKNAQNLLNERLYRIKPEALKFTSIVDTPEVIQAKINAVQISEVEKSRDNFNVRH 206 VE LL+E++ + A FTS +TP I K+N EV+K + + + Sbjct: 426 VETPVTPTITTLLDEKVQSVPLAATTFTSPSNTPASISPKLNVEVKKEVDKEKAVTDEK- 484 Query: 207 YGSYLDQKQLGPAQQWELSELSAMWTYPSDN 237 +++ P ++ E ++S+ + Y ++N Sbjct: 485 -----PKQKDKPGEEEEKCDISSKYHYLTEN 510 >gi|222352158 carboxypeptidase 3, cytosolic [Homo sapiens] Length = 920 Score = 29.6 bits (65), Expect = 2.4 Identities = 20/75 (26%), Positives = 31/75 (41%), Gaps = 17/75 (22%) Query: 172 KFTSIVDTPEVIQ---------AKINAVQISEVEKSRDNFNVRHYGSYLDQKQLGPAQQW 222 K IV T E++Q + QI ++ R NF ++H QL PA Sbjct: 737 KDKGIVQTQEILQYLLPIVHSTKNMQTTQIKQLFNPRTNFQIQH--------QLNPATCR 788 Query: 223 ELSELSAMWTYPSDN 237 + + S WT P ++ Sbjct: 789 NIKKYSTSWTAPRNH 803 >gi|68299795 chromodomain helicase DNA binding protein 1 [Homo sapiens] Length = 1710 Score = 29.6 bits (65), Expect = 2.4 Identities = 23/79 (29%), Positives = 36/79 (45%), Gaps = 6/79 (7%) Query: 91 VLVSDIDYRNYL--HQWTCLPDQNDVIQAKKAYDLQSDNLYKSDLEWLKGIGWLPEGSVE 148 V + DI+ RN + H+WT + + K L + + D +L G+ W G E Sbjct: 560 VYLGDINSRNMIRTHEWT----HHQTKRLKFNILLTTYEILLKDKAFLGGLNWAFIGVDE 615 Query: 149 VMRVKNAQNLLNERLYRIK 167 R+KN +LL + L K Sbjct: 616 AHRLKNDDSLLYKTLIDFK 634 >gi|110349721 titin isoform novex-3 [Homo sapiens] Length = 5604 Score = 28.9 bits (63), Expect = 4.1 Identities = 13/29 (44%), Positives = 15/29 (51%), Gaps = 2/29 (6%) Query: 8 PKPHTY--DLSLPEVPSYKYKEGYRKQLG 34 PKPH Y +P Y+YK Y KQ G Sbjct: 1109 PKPHVYWKKSGVPLTTGYRYKVSYNKQTG 1137 >gi|110349719 titin isoform N2-A [Homo sapiens] Length = 33423 Score = 28.9 bits (63), Expect = 4.1 Identities = 13/29 (44%), Positives = 15/29 (51%), Gaps = 2/29 (6%) Query: 8 PKPHTY--DLSLPEVPSYKYKEGYRKQLG 34 PKPH Y +P Y+YK Y KQ G Sbjct: 1109 PKPHVYWKKSGVPLTTGYRYKVSYNKQTG 1137 >gi|110349717 titin isoform novex-2 [Homo sapiens] Length = 27118 Score = 28.9 bits (63), Expect = 4.1 Identities = 13/29 (44%), Positives = 15/29 (51%), Gaps = 2/29 (6%) Query: 8 PKPHTY--DLSLPEVPSYKYKEGYRKQLG 34 PKPH Y +P Y+YK Y KQ G Sbjct: 1063 PKPHVYWKKSGVPLTTGYRYKVSYNKQTG 1091 >gi|110349713 titin isoform novex-1 [Homo sapiens] Length = 27051 Score = 28.9 bits (63), Expect = 4.1 Identities = 13/29 (44%), Positives = 15/29 (51%), Gaps = 2/29 (6%) Query: 8 PKPHTY--DLSLPEVPSYKYKEGYRKQLG 34 PKPH Y +P Y+YK Y KQ G Sbjct: 1063 PKPHVYWKKSGVPLTTGYRYKVSYNKQTG 1091 >gi|110349715 titin isoform N2-B [Homo sapiens] Length = 26926 Score = 28.9 bits (63), Expect = 4.1 Identities = 13/29 (44%), Positives = 15/29 (51%), Gaps = 2/29 (6%) Query: 8 PKPHTY--DLSLPEVPSYKYKEGYRKQLG 34 PKPH Y +P Y+YK Y KQ G Sbjct: 1063 PKPHVYWKKSGVPLTTGYRYKVSYNKQTG 1091 >gi|239741279 PREDICTED: similar to FLJ00310 protein [Homo sapiens] Length = 561 Score = 28.5 bits (62), Expect = 5.3 Identities = 34/159 (21%), Positives = 69/159 (43%), Gaps = 16/159 (10%) Query: 58 QSDREYKKAYEKSKGIHNTPLDMMSIVQAKKCQVLVSDIDYRNYLHQWTCLPDQNDVIQA 117 Q +E K+ YE ++ N S V+ + CQ+ H+ C+ Q D + Sbjct: 294 QQIKEMKEMYENAEAKVNNSTGKWSCVEERICQL----------QHENPCIEQQLDDVHQ 343 Query: 118 KKAYDLQSDNLYKSDLEWLKGIGWLPEGSVEVMRVKNAQNLLNERLYRIKPEALKFTSIV 177 K+ + N+ + +E K L E + ++M N + L E L++ + E + +V Sbjct: 344 KEDHKEIVTNIQRGFIESGKKDLMLEEKNKKLM---NECDHLKESLFQYEREKAERVVVV 400 Query: 178 DTPEVIQAKINAVQISEVEKSRDNFNVRHYGSYLDQKQL 216 + +A + +++ +E + + HY LD+ Q+ Sbjct: 401 RQLQQ-EAADSLKKLTMLESPLE--GISHYHINLDETQV 436 >gi|26080431 ATPase family, AAA domain containing 5 [Homo sapiens] Length = 1844 Score = 28.5 bits (62), Expect = 5.3 Identities = 27/107 (25%), Positives = 44/107 (41%), Gaps = 15/107 (14%) Query: 76 TPLDMMSIVQAKKCQVLVSDIDYRNYLHQWTCLPDQNDVIQAKKAYDLQSDNLYKSDLEW 135 TPL+M S V+ KK + V N HQ + +N+ + D + D +D Sbjct: 100 TPLEMFSNVEFKKKRKRV------NLSHQLNNIKTENEAPIEISSDDSKEDYSLNNDFV- 152 Query: 136 LKGIGWLPEGSVEVMRVKNAQNLLNERLYRIKPEALKFTSIVDTPEV 182 E S V+R K +L E + K + TS+ ++ +V Sbjct: 153 --------ESSTSVLRYKKQVEVLAENIQDTKSQPNTMTSLQNSKKV 191 >gi|45446749 kinesin family member 5A [Homo sapiens] Length = 1032 Score = 28.5 bits (62), Expect = 5.3 Identities = 23/76 (30%), Positives = 36/76 (47%), Gaps = 7/76 (9%) Query: 53 HAAKIQSDREYKKAYEKSKGIHNTPLDMMSIVQAK-KCQVLVSDIDYRNYLHQWTCLPDQ 111 H AKI+S EY ++ E K D +S AK + Q V ++ ++ PD Sbjct: 636 HEAKIRSLTEYMQSVELKKRHLEESYDSLSDELAKLQAQETVHEVALKDKE------PDT 689 Query: 112 NDVIQAKKAYDLQSDN 127 D + KKA +LQ ++ Sbjct: 690 QDADEVKKALELQMES 705 >gi|87298937 centrosomal protein 110kDa [Homo sapiens] Length = 2325 Score = 28.5 bits (62), Expect = 5.3 Identities = 36/160 (22%), Positives = 79/160 (49%), Gaps = 17/160 (10%) Query: 75 NTPLDMMSIVQAKKCQVLVSDIDYRNYLHQWTCLPDQNDVIQA-KKAYDLQSD-NLYKSD 132 N L +++Q + C+ L SD++ +N L + + ++ +A +K Y+L+ + YK D Sbjct: 307 NKSLKEEAMLQKQSCEELKSDLNTKNELLKQKTI----ELTRACQKQYELEQELAFYKID 362 Query: 133 LEWLKGIGWLPEGSVEVMRVKNAQNLLNERLYRIKPEALKFTSIVDTPEVIQAKINAVQI 192 ++ + + + P E+ + + + + Y+ A + + I+D+ + +Q K ++ Sbjct: 363 AKF-EPLNYYPSEYAEIDKAPDESPYIGKSRYKRNMFATE-SYIIDSAQAVQIK----KM 416 Query: 193 SEVEKSR-DNFNVRHY----GSYLDQKQLGPAQQWELSEL 227 E+ R D+ N+R + D+++ A Q LSEL Sbjct: 417 EPDEQLRNDHMNLRGHTPLDTQLEDKEKKISAAQTRLSEL 456 >gi|19923424 myotubularin related protein 9 [Homo sapiens] Length = 549 Score = 27.7 bits (60), Expect = 9.0 Identities = 11/34 (32%), Positives = 18/34 (52%) Query: 21 PSYKYKEGYRKQLGHHMGFRTLQDDPKSVWAIHA 54 P Y EG GHH+ + QD+ + +W +H+ Sbjct: 20 PFYPAVEGTLCLTGHHLILSSRQDNTEELWLLHS 53 >gi|112380630 leiomodin 1 (smooth muscle) [Homo sapiens] Length = 600 Score = 27.7 bits (60), Expect = 9.0 Identities = 22/85 (25%), Positives = 41/85 (48%), Gaps = 3/85 (3%) Query: 143 PEGSVEV-MRVKNAQNLLNERLYRIKPEALKFTSIVDTPEVIQAKINAVQISEVEKSRDN 201 P+GSV V +R +N + +Y EA+ +T +++Q +++ + +VE D Sbjct: 41 PDGSVPVGLRQRNQTEKQSTGVYN--REAMLNFCEKETKKLMQREMSMDESKQVETKTDA 98 Query: 202 FNVRHYGSYLDQKQLGPAQQWELSE 226 N G +K LGP + +L + Sbjct: 99 KNGEERGRDASKKALGPRRDSDLGK 123 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.316 0.132 0.403 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 9,292,605 Number of Sequences: 37866 Number of extensions: 378514 Number of successful extensions: 1193 Number of sequences better than 10.0: 22 Number of HSP's better than 10.0 without gapping: 9 Number of HSP's successfully gapped in prelim test: 13 Number of HSP's that attempted gapping in prelim test: 876 Number of HSP's gapped (non-prelim): 155 length of query: 237 length of database: 18,247,518 effective HSP length: 99 effective length of query: 138 effective length of database: 14,498,784 effective search space: 2000832192 effective search space used: 2000832192 T: 11 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.6 bits) S2: 60 (27.7 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.