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Search of human proteins with 239752137
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|239752137 PREDICTED: hypothetical protein [Homo sapiens]
(357 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|169215927 PREDICTED: hypothetical protein [Homo sapiens] 691 0.0
gi|239752137 PREDICTED: hypothetical protein [Homo sapiens] 691 0.0
gi|169215514 PREDICTED: hypothetical protein [Homo sapiens] 687 0.0
gi|169215483 PREDICTED: hypothetical protein isoform 2 [Homo sap... 681 0.0
gi|194294521 intersectin 2 isoform 1 [Homo sapiens] 64 3e-10
gi|194294525 intersectin 2 isoform 2 [Homo sapiens] 64 3e-10
gi|31982906 cingulin-like 1 [Homo sapiens] 62 8e-10
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 62 1e-09
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 62 1e-09
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 62 1e-09
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 62 1e-09
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 62 1e-09
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 62 1e-09
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 62 1e-09
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 62 1e-09
gi|42794779 myosin 18A isoform b [Homo sapiens] 61 2e-09
gi|28416946 myosin 18A isoform a [Homo sapiens] 61 2e-09
gi|194294523 intersectin 2 isoform 3 [Homo sapiens] 60 4e-09
gi|21735548 centrosomal protein 2 [Homo sapiens] 59 5e-09
gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens] 59 7e-09
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens] 59 7e-09
gi|238908495 similar to pleckstrin homology domain protein (5V32... 57 3e-08
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap... 57 3e-08
gi|63252896 tropomyosin 1 alpha chain isoform 3 [Homo sapiens] 56 4e-08
gi|35038601 spindle assembly abnormal protein 6 [Homo sapiens] 56 4e-08
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 56 6e-08
gi|223555975 tropomyosin 4 isoform 1 [Homo sapiens] 55 1e-07
gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens] 55 1e-07
gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens] 55 1e-07
gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens] 55 1e-07
>gi|169215927 PREDICTED: hypothetical protein [Homo sapiens]
Length = 357
Score = 691 bits (1783), Expect = 0.0
Identities = 357/357 (100%), Positives = 357/357 (100%)
Query: 1 MCRATLGLPLPPIVIQPARRSLPPIVTPASRRLGPRGGRHLGSVSTAMAATQELLLQLQK 60
MCRATLGLPLPPIVIQPARRSLPPIVTPASRRLGPRGGRHLGSVSTAMAATQELLLQLQK
Sbjct: 1 MCRATLGLPLPPIVIQPARRSLPPIVTPASRRLGPRGGRHLGSVSTAMAATQELLLQLQK 60
Query: 61 DNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPLQGEAREAAR 120
DNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPLQGEAREAAR
Sbjct: 61 DNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPLQGEAREAAR 120
Query: 121 ERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYYGGELQSQKSTEQQLAAQLV 180
ERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYYGGELQSQKSTEQQLAAQLV
Sbjct: 121 ERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYYGGELQSQKSTEQQLAAQLV 180
Query: 181 TLQNELELAETKCALQEEKLQQDALQTAEAWAIFQEQTVVLQVRPHSDAKEVQVKVMEAA 240
TLQNELELAETKCALQEEKLQQDALQTAEAWAIFQEQTVVLQVRPHSDAKEVQVKVMEAA
Sbjct: 181 TLQNELELAETKCALQEEKLQQDALQTAEAWAIFQEQTVVLQVRPHSDAKEVQVKVMEAA 240
Query: 241 EELDAWQSGRELCDGQLRGVQYSTESLMEEMARADRETRLFGGPRALAIRRCVLGALQVL 300
EELDAWQSGRELCDGQLRGVQYSTESLMEEMARADRETRLFGGPRALAIRRCVLGALQVL
Sbjct: 241 EELDAWQSGRELCDGQLRGVQYSTESLMEEMARADRETRLFGGPRALAIRRCVLGALQVL 300
Query: 301 LTLPLLFLGLSLLWTVLLDPGAVSAWLWSLTSETTLRRLRYTLSPLLELRANGLLPT 357
LTLPLLFLGLSLLWTVLLDPGAVSAWLWSLTSETTLRRLRYTLSPLLELRANGLLPT
Sbjct: 301 LTLPLLFLGLSLLWTVLLDPGAVSAWLWSLTSETTLRRLRYTLSPLLELRANGLLPT 357
>gi|239752137 PREDICTED: hypothetical protein [Homo sapiens]
Length = 357
Score = 691 bits (1783), Expect = 0.0
Identities = 357/357 (100%), Positives = 357/357 (100%)
Query: 1 MCRATLGLPLPPIVIQPARRSLPPIVTPASRRLGPRGGRHLGSVSTAMAATQELLLQLQK 60
MCRATLGLPLPPIVIQPARRSLPPIVTPASRRLGPRGGRHLGSVSTAMAATQELLLQLQK
Sbjct: 1 MCRATLGLPLPPIVIQPARRSLPPIVTPASRRLGPRGGRHLGSVSTAMAATQELLLQLQK 60
Query: 61 DNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPLQGEAREAAR 120
DNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPLQGEAREAAR
Sbjct: 61 DNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPLQGEAREAAR 120
Query: 121 ERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYYGGELQSQKSTEQQLAAQLV 180
ERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYYGGELQSQKSTEQQLAAQLV
Sbjct: 121 ERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYYGGELQSQKSTEQQLAAQLV 180
Query: 181 TLQNELELAETKCALQEEKLQQDALQTAEAWAIFQEQTVVLQVRPHSDAKEVQVKVMEAA 240
TLQNELELAETKCALQEEKLQQDALQTAEAWAIFQEQTVVLQVRPHSDAKEVQVKVMEAA
Sbjct: 181 TLQNELELAETKCALQEEKLQQDALQTAEAWAIFQEQTVVLQVRPHSDAKEVQVKVMEAA 240
Query: 241 EELDAWQSGRELCDGQLRGVQYSTESLMEEMARADRETRLFGGPRALAIRRCVLGALQVL 300
EELDAWQSGRELCDGQLRGVQYSTESLMEEMARADRETRLFGGPRALAIRRCVLGALQVL
Sbjct: 241 EELDAWQSGRELCDGQLRGVQYSTESLMEEMARADRETRLFGGPRALAIRRCVLGALQVL 300
Query: 301 LTLPLLFLGLSLLWTVLLDPGAVSAWLWSLTSETTLRRLRYTLSPLLELRANGLLPT 357
LTLPLLFLGLSLLWTVLLDPGAVSAWLWSLTSETTLRRLRYTLSPLLELRANGLLPT
Sbjct: 301 LTLPLLFLGLSLLWTVLLDPGAVSAWLWSLTSETTLRRLRYTLSPLLELRANGLLPT 357
>gi|169215514 PREDICTED: hypothetical protein [Homo sapiens]
Length = 357
Score = 687 bits (1774), Expect = 0.0
Identities = 356/357 (99%), Positives = 356/357 (99%)
Query: 1 MCRATLGLPLPPIVIQPARRSLPPIVTPASRRLGPRGGRHLGSVSTAMAATQELLLQLQK 60
MCRATLGLPLPPIVIQPARRSLPPIVTPASRRLGPRGGRHLGSVSTAMAATQELLLQLQK
Sbjct: 1 MCRATLGLPLPPIVIQPARRSLPPIVTPASRRLGPRGGRHLGSVSTAMAATQELLLQLQK 60
Query: 61 DNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPLQGEAREAAR 120
DNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPLQGEAREAAR
Sbjct: 61 DNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPLQGEAREAAR 120
Query: 121 ERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYYGGELQSQKSTEQQLAAQLV 180
ERAERVRRRLEEAERHKE LEQHSRQLQEQWEELSSQLFYYGGELQSQKSTEQQLAAQLV
Sbjct: 121 ERAERVRRRLEEAERHKEYLEQHSRQLQEQWEELSSQLFYYGGELQSQKSTEQQLAAQLV 180
Query: 181 TLQNELELAETKCALQEEKLQQDALQTAEAWAIFQEQTVVLQVRPHSDAKEVQVKVMEAA 240
TLQNELELAETKCALQEEKLQQDALQTAEAWAIFQEQTVVLQVRPHSDAKEVQVKVMEAA
Sbjct: 181 TLQNELELAETKCALQEEKLQQDALQTAEAWAIFQEQTVVLQVRPHSDAKEVQVKVMEAA 240
Query: 241 EELDAWQSGRELCDGQLRGVQYSTESLMEEMARADRETRLFGGPRALAIRRCVLGALQVL 300
EELDAWQSGRELCDGQLRGVQYSTESLMEEMARADRETRLFGGPRALAIRRCVLGALQVL
Sbjct: 241 EELDAWQSGRELCDGQLRGVQYSTESLMEEMARADRETRLFGGPRALAIRRCVLGALQVL 300
Query: 301 LTLPLLFLGLSLLWTVLLDPGAVSAWLWSLTSETTLRRLRYTLSPLLELRANGLLPT 357
LTLPLLFLGLSLLWTVLLDPGAVSAWLWSLTSETTLRRLRYTLSPLLELRANGLLPT
Sbjct: 301 LTLPLLFLGLSLLWTVLLDPGAVSAWLWSLTSETTLRRLRYTLSPLLELRANGLLPT 357
>gi|169215483 PREDICTED: hypothetical protein isoform 2 [Homo
sapiens]
Length = 356
Score = 681 bits (1757), Expect = 0.0
Identities = 355/357 (99%), Positives = 355/357 (99%), Gaps = 1/357 (0%)
Query: 1 MCRATLGLPLPPIVIQPARRSLPPIVTPASRRLGPRGGRHLGSVSTAMAATQELLLQLQK 60
MCRATLGLPLPPIVIQPARRSLPPIVTPASRRLGPRGGRHLGSVSTAMAATQELLLQLQK
Sbjct: 1 MCRATLGLPLPPIVIQPARRSLPPIVTPASRRLGPRGGRHLGSVSTAMAATQELLLQLQK 60
Query: 61 DNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPLQGEAREAAR 120
DNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPLQGEAREAAR
Sbjct: 61 DNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPLQGEAREAAR 120
Query: 121 ERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYYGGELQSQKSTEQQLAAQLV 180
ERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFY GGE QSQKSTEQQLAAQLV
Sbjct: 121 ERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFY-GGEPQSQKSTEQQLAAQLV 179
Query: 181 TLQNELELAETKCALQEEKLQQDALQTAEAWAIFQEQTVVLQVRPHSDAKEVQVKVMEAA 240
TLQNELELAETKCALQEEKLQQDALQTAEAWAIFQEQTVVLQVRPHSDAKEVQVKVMEAA
Sbjct: 180 TLQNELELAETKCALQEEKLQQDALQTAEAWAIFQEQTVVLQVRPHSDAKEVQVKVMEAA 239
Query: 241 EELDAWQSGRELCDGQLRGVQYSTESLMEEMARADRETRLFGGPRALAIRRCVLGALQVL 300
EELDAWQSGRELCDGQLRGVQYSTESLMEEMARADRETRLFGGPRALAIRRCVLGALQVL
Sbjct: 240 EELDAWQSGRELCDGQLRGVQYSTESLMEEMARADRETRLFGGPRALAIRRCVLGALQVL 299
Query: 301 LTLPLLFLGLSLLWTVLLDPGAVSAWLWSLTSETTLRRLRYTLSPLLELRANGLLPT 357
LTLPLLFLGLSLLWTVLLDPGAVSAWLWSLTSETTLRRLRYTLSPLLELRANGLLPT
Sbjct: 300 LTLPLLFLGLSLLWTVLLDPGAVSAWLWSLTSETTLRRLRYTLSPLLELRANGLLPT 356
>gi|194294521 intersectin 2 isoform 1 [Homo sapiens]
Length = 1697
Score = 63.5 bits (153), Expect = 3e-10
Identities = 74/276 (26%), Positives = 126/276 (45%), Gaps = 33/276 (11%)
Query: 52 QELLLQLQKD-NRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQP 110
Q L+ Q Q++ R ++ K+E E+ R L+ + L+ E++R L R+R + +
Sbjct: 383 QALMEQQQREAERKAQKEKEEWERKQRELQEQEWKKQLELEKRLEKQRELERQREEERRK 442
Query: 111 LQGEAREAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYYGGELQSQKS 170
E REAA++ ER RR E R +E L Q +R+ QE+ L+S+ EL++
Sbjct: 443 -DIERREAAKQELERQRRLEWERIRRQELLNQKNRE-QEEIVRLNSKKKNLHLELEALNG 500
Query: 171 TEQQLAAQL-------VTLQNELELAETKCALQ--EEKLQQDALQTAEAWAIFQEQTVVL 221
QQ++ +L T + ELE+ + +C L+ E K Q LQ + Q ++
Sbjct: 501 KHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQQELQ--------EYQNKLI 552
Query: 222 QVRPHSDAKEVQVKVMEAAEELDAWQS--------GRELCD---GQLRGVQYSTESLMEE 270
+ P ++K M+ + D+ S ELC QL ++ T S + E
Sbjct: 553 YLVPEKQLLNERIKNMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQLDALEKETASKLSE 612
Query: 271 MARADRETRLFGGPRALAIRRCVLGALQVLLTLPLL 306
M + + + G ++ +C+L L L L LL
Sbjct: 613 MDSFNNQLKC--GNMDDSVLQCLLSLLSCLNNLFLL 646
Score = 46.6 bits (109), Expect = 3e-05
Identities = 64/273 (23%), Positives = 122/273 (44%), Gaps = 42/273 (15%)
Query: 16 QPARRSLPPIVTPASRRLGPRGGRHLGSVSTAMAATQELLLQLQKDNRDGRQRKQELEKL 75
QP +LPP + P S R GG+ + S++ + + Q++ Q++ + +K
Sbjct: 316 QPLPLTLPPELVPPSFR----GGKQIDSINGTLPSYQKM----QEEEPQKKLPVTFEDKR 367
Query: 76 MRGLEAESESLNQRLQDLSERERSLLRRRSQAAQP----LQGEAREAARERAERVRRRLE 131
E + L +R Q L E+++ R++Q + Q E +E ++ + +RLE
Sbjct: 368 KANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWERKQRELQEQEWKKQLELEKRLE 427
Query: 132 ---EAERHKE-----DLEQH-------SRQLQEQWEELSSQLFYYGGELQSQKSTEQQ-- 174
E ER +E D+E+ RQ + +WE + Q EL +QK+ EQ+
Sbjct: 428 KQRELERQREEERRKDIERREAAKQELERQRRLEWERIRRQ------ELLNQKNREQEEI 481
Query: 175 --LAAQLVTLQNELELAETKCALQEEKLQQDAL--QTAEAWAIFQEQTVVLQVRPHSDAK 230
L ++ L ELE K +LQ L QT + ++ L++ + K
Sbjct: 482 VRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEI---MEIK 538
Query: 231 EVQVKVMEAAEELDAWQSGRELCDGQLRGVQYS 263
++Q ++ E +L ++L + +++ +Q+S
Sbjct: 539 QLQQELQEYQNKLIYLVPEKQLLNERIKNMQFS 571
Score = 31.2 bits (69), Expect = 1.5
Identities = 33/167 (19%), Positives = 70/167 (41%), Gaps = 6/167 (3%)
Query: 120 RERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYYGGELQSQKSTEQQLAAQL 179
+ +A R +E +R + +EQ R+ + + ++ + ELQ Q+ +Q +
Sbjct: 366 KRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWERKQRELQEQEWKKQLELEKR 425
Query: 180 VTLQNELELAETKCALQEEKLQQDALQTAE-----AWAIFQEQTVVLQV-RPHSDAKEVQ 233
+ Q ELE + ++ + ++ A Q E W + Q ++ Q R + +
Sbjct: 426 LEKQRELERQREEERRKDIERREAAKQELERQRRLEWERIRRQELLNQKNREQEEIVRLN 485
Query: 234 VKVMEAAEELDAWQSGRELCDGQLRGVQYSTESLMEEMARADRETRL 280
K EL+A + G+L+ V+ ++ E+ D++ L
Sbjct: 486 SKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDL 532
>gi|194294525 intersectin 2 isoform 2 [Homo sapiens]
Length = 1249
Score = 63.5 bits (153), Expect = 3e-10
Identities = 74/276 (26%), Positives = 126/276 (45%), Gaps = 33/276 (11%)
Query: 52 QELLLQLQKD-NRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQP 110
Q L+ Q Q++ R ++ K+E E+ R L+ + L+ E++R L R+R + +
Sbjct: 383 QALMEQQQREAERKAQKEKEEWERKQRELQEQEWKKQLELEKRLEKQRELERQREEERRK 442
Query: 111 LQGEAREAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYYGGELQSQKS 170
E REAA++ ER RR E R +E L Q +R+ QE+ L+S+ EL++
Sbjct: 443 -DIERREAAKQELERQRRLEWERIRRQELLNQKNRE-QEEIVRLNSKKKNLHLELEALNG 500
Query: 171 TEQQLAAQL-------VTLQNELELAETKCALQ--EEKLQQDALQTAEAWAIFQEQTVVL 221
QQ++ +L T + ELE+ + +C L+ E K Q LQ + Q ++
Sbjct: 501 KHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQQELQ--------EYQNKLI 552
Query: 222 QVRPHSDAKEVQVKVMEAAEELDAWQS--------GRELCD---GQLRGVQYSTESLMEE 270
+ P ++K M+ + D+ S ELC QL ++ T S + E
Sbjct: 553 YLVPEKQLLNERIKNMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQLDALEKETASKLSE 612
Query: 271 MARADRETRLFGGPRALAIRRCVLGALQVLLTLPLL 306
M + + + G ++ +C+L L L L LL
Sbjct: 613 MDSFNNQLKC--GNMDDSVLQCLLSLLSCLNNLFLL 646
Score = 46.6 bits (109), Expect = 3e-05
Identities = 64/273 (23%), Positives = 122/273 (44%), Gaps = 42/273 (15%)
Query: 16 QPARRSLPPIVTPASRRLGPRGGRHLGSVSTAMAATQELLLQLQKDNRDGRQRKQELEKL 75
QP +LPP + P S R GG+ + S++ + + Q++ Q++ + +K
Sbjct: 316 QPLPLTLPPELVPPSFR----GGKQIDSINGTLPSYQKM----QEEEPQKKLPVTFEDKR 367
Query: 76 MRGLEAESESLNQRLQDLSERERSLLRRRSQAAQP----LQGEAREAARERAERVRRRLE 131
E + L +R Q L E+++ R++Q + Q E +E ++ + +RLE
Sbjct: 368 KANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWERKQRELQEQEWKKQLELEKRLE 427
Query: 132 ---EAERHKE-----DLEQH-------SRQLQEQWEELSSQLFYYGGELQSQKSTEQQ-- 174
E ER +E D+E+ RQ + +WE + Q EL +QK+ EQ+
Sbjct: 428 KQRELERQREEERRKDIERREAAKQELERQRRLEWERIRRQ------ELLNQKNREQEEI 481
Query: 175 --LAAQLVTLQNELELAETKCALQEEKLQQDAL--QTAEAWAIFQEQTVVLQVRPHSDAK 230
L ++ L ELE K +LQ L QT + ++ L++ + K
Sbjct: 482 VRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEI---MEIK 538
Query: 231 EVQVKVMEAAEELDAWQSGRELCDGQLRGVQYS 263
++Q ++ E +L ++L + +++ +Q+S
Sbjct: 539 QLQQELQEYQNKLIYLVPEKQLLNERIKNMQFS 571
Score = 31.2 bits (69), Expect = 1.5
Identities = 33/167 (19%), Positives = 70/167 (41%), Gaps = 6/167 (3%)
Query: 120 RERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYYGGELQSQKSTEQQLAAQL 179
+ +A R +E +R + +EQ R+ + + ++ + ELQ Q+ +Q +
Sbjct: 366 KRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWERKQRELQEQEWKKQLELEKR 425
Query: 180 VTLQNELELAETKCALQEEKLQQDALQTAE-----AWAIFQEQTVVLQV-RPHSDAKEVQ 233
+ Q ELE + ++ + ++ A Q E W + Q ++ Q R + +
Sbjct: 426 LEKQRELERQREEERRKDIERREAAKQELERQRRLEWERIRRQELLNQKNREQEEIVRLN 485
Query: 234 VKVMEAAEELDAWQSGRELCDGQLRGVQYSTESLMEEMARADRETRL 280
K EL+A + G+L+ V+ ++ E+ D++ L
Sbjct: 486 SKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDL 532
>gi|31982906 cingulin-like 1 [Homo sapiens]
Length = 1302
Score = 62.0 bits (149), Expect = 8e-10
Identities = 59/250 (23%), Positives = 113/250 (45%), Gaps = 21/250 (8%)
Query: 48 MAATQELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQA 107
M +E L Q+ + ++Q LE+ ++ LE E E+ + D S + + + SQ
Sbjct: 1014 MRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQL 1073
Query: 108 AQPLQGEAREA---------ARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQL 158
L+ E + +RE+ E++R L + ++DLE L+ Q ++L S++
Sbjct: 1074 EMELEEERNNSDLLSERISRSREQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRI 1133
Query: 159 FYYGGELQSQK-STEQQLAAQLVTLQNELELAE-TKCALQ------EEKLQQDALQTAEA 210
+ G +S K Q+ A++ L++ LE E + LQ E K+++ +Q +
Sbjct: 1134 IHLEGSYRSSKEGLVVQMEARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDE 1193
Query: 211 WAIFQEQTVVLQVRPHSDAKEVQVKVMEAAEELDAWQSGRELCDGQLRGVQYSTESLMEE 270
+Q L +R K ++ +V EA EE+D +S ++ +L E L +
Sbjct: 1194 HLSLTDQKDQLSLR----LKAMKRQVEEAEEEIDRLESSKKKLQRELEEQMDMNEHLQGQ 1249
Query: 271 MARADRETRL 280
+ ++ RL
Sbjct: 1250 LNSMKKDLRL 1259
Score = 47.8 bits (112), Expect = 2e-05
Identities = 45/212 (21%), Positives = 94/212 (44%), Gaps = 38/212 (17%)
Query: 70 QELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPLQG---------EAREAAR 120
QE++KL +AE ++L + +++ ++ L R + + Q G E E +
Sbjct: 776 QEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQ 835
Query: 121 ERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYYGGELQSQKSTEQQLAAQLV 180
R+E + RR+ + +R EDL+ + +E ++ ++ L + E++ +
Sbjct: 836 GRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARR 895
Query: 181 TLQNELELAETKCALQEEKLQQDALQTAEAWAIFQEQTVVLQVRPHSDAKEVQVKVMEAA 240
L+NELE A Q + QT + +++ + +++ S+ KE Q++ ++
Sbjct: 896 ALENELEAA-----------QGNLSQTTQ-----EQKQLSEKLKEESEQKE-QLRRLKNE 938
Query: 241 EELDAWQSGRELCDGQLRGVQYSTESLMEEMA 272
E + W G+ + E L +EMA
Sbjct: 939 MENERWHLGKTI------------EKLQKEMA 958
Score = 43.1 bits (100), Expect = 4e-04
Identities = 61/246 (24%), Positives = 109/246 (44%), Gaps = 28/246 (11%)
Query: 46 TAMAATQELLLQLQKDNRDGRQRK-----QELEKLMRGLEAESESLNQ------RLQDLS 94
TA L + DN D +RK ++++ L ++ NQ ++DL
Sbjct: 554 TAKQILYNYLKEGSTDNDDATKRKVNLVFEKIQTLKSRAAGSAQGNNQACNSTSEVKDLL 613
Query: 95 ERERSLLRRRSQAAQPLQGEAR--EAARERAERVRRRLEE-AERHKEDLEQHS---RQLQ 148
E++ L ++ + LQ E + + +E ER+R LEE +H E +E++S ++L+
Sbjct: 614 EQKSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQHNEKVEENSTLQQRLE 673
Query: 149 EQWEELS---SQLFYYGGELQSQKSTEQQLAAQLVTLQNELELAE-----TKCALQEEKL 200
E EL +LF E + ++ + L QL + +EL+ A+ K AL EE L
Sbjct: 674 ESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIEELL 733
Query: 201 QQDALQTAEAWAIFQEQTVVLQVRPHSDAKEVQVKVMEAAEELD-AWQSGRELCDGQLRG 259
Q A Q + I +E+ L + + ++ + E D +E D +L+
Sbjct: 734 Q--AKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQA 791
Query: 260 VQYSTE 265
++ S E
Sbjct: 792 LRESVE 797
Score = 41.6 bits (96), Expect = 0.001
Identities = 40/165 (24%), Positives = 70/165 (42%), Gaps = 22/165 (13%)
Query: 49 AATQELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLN---QRLQDLSERERSLLRRRS 105
A T+ + LQ++N + R +ELE+ + L+ + E L + ++ ++ +R+
Sbjct: 818 AGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLE 877
Query: 106 QAAQPLQGEAREAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYYGGEL 165
+A + E +EA R + LE A+ + Q +QL E+ +E S Q
Sbjct: 878 EALVHARKEEKEAVSAR-RALENELEAAQGNLSQTTQEQKQLSEKLKEESEQ-------- 928
Query: 166 QSQKSTEQQLAAQLVTLQNELELAETKCALQEEKLQQDALQTAEA 210
QL L+NE+E EKLQ++ EA
Sbjct: 929 ----------KEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEA 963
Score = 37.7 bits (86), Expect = 0.016
Identities = 43/222 (19%), Positives = 87/222 (39%), Gaps = 13/222 (5%)
Query: 61 DNRDGRQRKQELEKLMRGLEAESESLNQRLQDL---SERERSLLRRRSQAAQPLQGEARE 117
D D +R ++ EK L E Q LQDL E + LLR+R + L+G +
Sbjct: 712 DELDSAKRSEDREK--GALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALK- 768
Query: 118 AARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYYGGELQSQKSTEQQLAA 177
E V +E ++ KE + + L+E EE + + + + +
Sbjct: 769 ------EEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEM 822
Query: 178 QLVTLQNELELAETKCALQEEKLQQDALQTAEAWAIFQEQTVVLQVRPHSDAKEVQVKVM 237
++ LQ E E + + E ++ Q Q + + L+ + + ++++ ++
Sbjct: 823 RVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLK-KYEGEIRQLEEALV 881
Query: 238 EAAEELDAWQSGRELCDGQLRGVQYSTESLMEEMARADRETR 279
A +E S R + +L Q + +E + + +
Sbjct: 882 HARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLK 923
Score = 32.7 bits (73), Expect = 0.51
Identities = 36/149 (24%), Positives = 72/149 (48%), Gaps = 15/149 (10%)
Query: 48 MAATQELLLQLQKDNRDGRQRKQELEKLMRGLEAES-------ESLNQRLQDLSERER-S 99
++ T + QL + ++ ++K++L +L +E E E L + + D+ E R S
Sbjct: 908 LSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTS 967
Query: 100 LLRRRSQAAQPLQGEAREAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLF 159
L ++Q + + RE A E +++ + EAE+ + + ++Q++ + +L
Sbjct: 968 TLELQNQLDEYKEKNRRELA-EMQRQLKEKTLEAEKSR----LTAMKMQDEMRLMEEELR 1022
Query: 160 YYGGELQSQKSTEQQLAAQ-LVTLQNELE 187
Y Q + T++QL Q L L+ ELE
Sbjct: 1023 DY-QRAQDEALTKRQLLEQTLKDLEYELE 1050
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 61.6 bits (148), Expect = 1e-09
Identities = 73/249 (29%), Positives = 115/249 (46%), Gaps = 19/249 (7%)
Query: 47 AMAATQELLLQLQKDNRDGRQRKQE--------LEKLMRGLEAESESLNQRLQD-LSERE 97
A+ A +EL LQ ++ R RQ + E LE R EAE +S + ++ E
Sbjct: 1534 ALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE 1593
Query: 98 RSLLRRRSQAAQPLQGEAREAARERAERVRRRLEEAERHKEDLEQHSRQ---LQEQWEEL 154
RSL AQ L+ EA A+++AE R R EEAER E + + + L+ Q EE+
Sbjct: 1594 RSLQEEHVAVAQ-LREEAERRAQQQAEAERAR-EEAERELERWQLKANEALRLRLQAEEV 1651
Query: 155 SSQLFYYGGELQSQKSTEQQLAAQLVTLQNELELAETKCALQE-EKLQQDALQTAEAWAI 213
+ Q E + QK E + A+ E + + + A QE EK +Q A TA+
Sbjct: 1652 AQQKSLAQAEAEKQKE-EAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLA 1710
Query: 214 FQEQTVVLQVRPHSDAKEVQVKVMEAAE---ELDAWQSGRELCDGQLRGVQYSTESLMEE 270
+++ + L+ ++ Q+ E A E A R+ + +L V+ E L+
Sbjct: 1711 AEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLAS 1770
Query: 271 MARADRETR 279
ARA+ E+R
Sbjct: 1771 KARAEEESR 1779
Score = 56.2 bits (134), Expect = 4e-08
Identities = 72/261 (27%), Positives = 105/261 (40%), Gaps = 32/261 (12%)
Query: 43 SVSTAMAATQELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQR-LQDLSERERSLL 101
S A A EL L+L GR R + L +AE E+ QR L ER R
Sbjct: 1933 SFEKAAAGKAELELEL------GRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREA 1986
Query: 102 RRRSQAAQPLQGEA---REAARERAERVRRRLEEAERHKEDLEQHS-RQLQEQWEELSSQ 157
R Q + + EA R+AA E ER++ ++EEA R +E EQ S RQLQ E +
Sbjct: 1987 EERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKR 2046
Query: 158 L--------FYYGGELQSQKSTEQQLAAQLVTLQNELELAETKCALQEE-------KLQQ 202
L F + Q + T QQ + L L+ E E A EE + Q
Sbjct: 2047 LQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQ 2106
Query: 203 DALQTAEAWAIFQEQTVVLQVRPHSDA------KEVQVKVMEAAEELDAWQSGRELCDGQ 256
Q EA + Q Q R + A KE + + A+ A ++ D +
Sbjct: 2107 SRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAE 2166
Query: 257 LRGVQYSTESLMEEMARADRE 277
+ + E + + A+ ++E
Sbjct: 2167 MEKHKKFAEQTLRQKAQVEQE 2187
Score = 54.7 bits (130), Expect = 1e-07
Identities = 47/157 (29%), Positives = 77/157 (49%), Gaps = 5/157 (3%)
Query: 52 QELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPL 111
+E L +LQ++ Q++QELE + + AE E L E RS + Q +
Sbjct: 1733 EEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAE 1792
Query: 112 QGEAREAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYYGGELQSQKST 171
G RE A E A R+R EEA+R ++ E+ + + + + E + ++ GE K T
Sbjct: 1793 AGRFRELA-EEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLK-T 1850
Query: 172 EQQLAAQLVTLQNE--LELAETKCALQEEKLQQDALQ 206
E ++A + +NE LAE + A Q +L++ A Q
Sbjct: 1851 EAEIALKEKEAENERLRRLAEDE-AFQRRRLEEQAAQ 1886
Score = 52.4 bits (124), Expect = 6e-07
Identities = 64/274 (23%), Positives = 114/274 (41%), Gaps = 52/274 (18%)
Query: 47 AMAATQELLLQLQKDNRDGRQRKQELEKLMRGLE------AESESLNQRLQDLSERERSL 100
A +E +Q +++ R++ +E E+L + E A++++ ++L+ +E+E +
Sbjct: 2089 AAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAA- 2147
Query: 101 LRRRSQAAQPLQGEAREAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFY 160
RR+QA Q + ++AA E+ ++ E+ R K +EQ L+ Q EE Q
Sbjct: 2148 --RRAQAEQAALRQ-KQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL 2204
Query: 161 YGGELQSQKSTEQQLAAQLVTLQNEL--------ELAETKCAL----------------- 195
ELQ K+ + A Q ++ EL EL++ K +
Sbjct: 2205 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2264
Query: 196 ----QEEKLQQDALQTAEAWAIFQEQTVVLQVRPHSDA----------KEVQVKVMEAAE 241
+ EK++Q A + A QE + Q+ A KE V EA
Sbjct: 2265 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2324
Query: 242 ---ELDAWQSGRELCDGQLRGVQYSTESLMEEMA 272
E + Q +EL Q R +Q E + +++A
Sbjct: 2325 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLA 2358
Score = 50.8 bits (120), Expect = 2e-06
Identities = 61/250 (24%), Positives = 112/250 (44%), Gaps = 35/250 (14%)
Query: 52 QELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPL 111
Q L + ++ RQ ++E E+L R ++ ES+ Q +L+ R ++ + + L
Sbjct: 1476 QALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRAL 1535
Query: 112 QGEAREAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYYGGELQSQKST 171
Q A E R +AE RRL +AE + +RQ+Q E ELQS++++
Sbjct: 1536 Q--ALEELRLQAEEAERRLRQAE------VERARQVQVALETAQRSA---EAELQSKRAS 1584
Query: 172 EQQLAAQLV-TLQNE-------LELAETKCALQ--EEKLQQDALQTAEAWAIFQEQTVVL 221
+ AQL +LQ E E AE + Q E+ +++A + E W + + + L
Sbjct: 1585 FAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRL 1644
Query: 222 QVRPHSDAKEVQVKVMEAAE-----ELDAWQSG---------RELCDGQLRGVQYSTESL 267
+++ A++ + EA + E +A + G REL + +L + E
Sbjct: 1645 RLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGT 1704
Query: 268 MEEMARADRE 277
++ A++E
Sbjct: 1705 AQQRLAAEQE 1714
Score = 48.9 bits (115), Expect = 7e-06
Identities = 63/267 (23%), Positives = 114/267 (42%), Gaps = 57/267 (21%)
Query: 57 QLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSER----ERSLLRRRSQAAQPLQ 112
Q++++ R + +EL KL +EAE+ +L R +D ++R E +++ ++ A L
Sbjct: 2225 QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLS 2284
Query: 113 GEAREAARER---------------------------AERVRRRLEEAERHKEDLEQHSR 145
A+EAAR R A R++ E ++ KE ++ +R
Sbjct: 2285 VAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR 2344
Query: 146 QLQEQWEELSSQL------FYYGGELQSQKSTEQQLAAQLVTLQNELELAETKCALQE-- 197
+LQE E+++ QL F E + Q+ E A+ + L+ E++ + +E
Sbjct: 2345 RLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLR-VAEMSRAQARAEEDA 2403
Query: 198 -----------EKLQQDALQTAEAWAIFQEQTVVLQVRPHSDAKEVQVKVMEAAEELDAW 246
EKL + L T E + Q + Q H DA+ ++ + E E +
Sbjct: 2404 QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH-DAERLREAIAELEREKEKL 2462
Query: 247 QSGRELCDGQLRGVQYST---ESLMEE 270
Q +L QL+ + T E L++E
Sbjct: 2463 QQEAKLL--QLKSEEMQTVQQEQLLQE 2487
Score = 47.8 bits (112), Expect = 2e-05
Identities = 62/265 (23%), Positives = 107/265 (40%), Gaps = 30/265 (11%)
Query: 19 RRSLPPIVTPASRRLGPRGGRHL----GSVSTAMAATQELLLQLQKDNRDGRQRKQELEK 74
+ L P+ +PA + G + + T + L Q K + +R +E E+
Sbjct: 1290 KAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER 1349
Query: 75 LMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPLQGEAREAARERAERVRRRLEEAE 134
L AE ++ E++R L +QA + EA+E + E V RR E A
Sbjct: 1350 LAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA- 1408
Query: 135 RHKEDLEQHSRQLQEQWEELSSQLFYYGGELQSQKSTEQQLAAQLVTLQNELELAETKCA 194
D +Q R +QE+ ++L E + Q Q AA+ L+ E E+ +
Sbjct: 1409 ---VDAQQQKRSIQEELQQLRQ-----SSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ 1460
Query: 195 LQEEKLQQDALQTAEAWAIFQEQTVVLQVRPHSDAKEVQVKVMEAAEELDAWQSGRELCD 254
L+ + Q+ + E A+ + A+E + + +A EE + + R++ D
Sbjct: 1461 LEATERQRGGAE-GELQAL------------RARAEEAEAQKRQAQEEAERLR--RQVQD 1505
Query: 255 GQLRGVQYSTE--SLMEEMARADRE 277
R Q E S ++ A A RE
Sbjct: 1506 ESQRKRQAEVELASRVKAEAEAARE 1530
Score = 45.1 bits (105), Expect = 1e-04
Identities = 69/283 (24%), Positives = 110/283 (38%), Gaps = 64/283 (22%)
Query: 45 STAMAATQELLLQLQKD---------NRDGRQRKQELEKLMRGLEAESESLNQRLQDLS- 94
+T + A E LLQ QK+ D Q Q+L + +G + E+ QR ++S
Sbjct: 2322 ATRLKAEAE-LLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSA 2380
Query: 95 ERERSLLR---------RRSQAAQPLQGEARE----------AARER------------- 122
E ER LR R + AQ + +A E A +E+
Sbjct: 2381 EAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQ 2440
Query: 123 ----AERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYYGGELQSQKSTEQQLAAQ 178
AER+R + E ER KE L+Q ++ LQ + EE+ Q ++QL +
Sbjct: 2441 SDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM-------------QTVQQEQLLQE 2487
Query: 179 LVTLQNELELAETKCALQEEKLQQDALQTAEAWAIFQEQTVVLQVRPHSDAKEVQVKVME 238
LQ L+E LQ E+ + + A+ +FQ++ Q ++ Q E
Sbjct: 2488 TQALQQSF-LSEKDSLLQRERFIEQ--EKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQE 2544
Query: 239 AAEELDAWQSGRELCDGQLRGVQYSTESLME-EMARADRETRL 280
+ + + R GV+ E L + E R +E L
Sbjct: 2545 RQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELL 2587
Score = 43.5 bits (101), Expect = 3e-04
Identities = 70/286 (24%), Positives = 121/286 (42%), Gaps = 53/286 (18%)
Query: 32 RLGPRGGRHLGSVSTAMAATQELLLQLQKDNRDGRQRKQELEKLMRGLEAESES---LNQ 88
RL R G V +LL + Q R++ELE+L R L ES L
Sbjct: 1162 RLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGA 1221
Query: 89 RLQDLSERERSLLRRRSQAAQPLQGEAREAARERAERVRRRLEEAERHKEDLEQ---HSR 145
LQD RRR + Q + +A RE+ + + LEE ERH E +E+ ++
Sbjct: 1222 WLQDA--------RRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAK 1273
Query: 146 QLQEQWEELSSQLFYYGGELQS----------QKSTEQQLA---------AQLVTLQNE- 185
Q ++ QL Y +L+ Q +E + ++L TL ++
Sbjct: 1274 QYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQY 1333
Query: 186 -------LELAETKCALQEEKLQQDALQTAEAWAIFQEQTVVLQVRPHS------DAKEV 232
L E + L E++ ++ + AE A ++Q + + + +AKE+
Sbjct: 1334 IKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKEL 1393
Query: 233 QVKVMEAA---EE--LDAWQSGRELCDGQLRGVQYSTESLMEEMAR 273
Q ++ E EE +DA Q R + + +L+ ++ S+E+ ++ AR
Sbjct: 1394 QQRMQEEVVRREEAAVDAQQQKRSIQE-ELQQLRQSSEAEIQAKAR 1438
Score = 42.0 bits (97), Expect = 8e-04
Identities = 65/240 (27%), Positives = 105/240 (43%), Gaps = 53/240 (22%)
Query: 53 ELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQ------RLQDLSE---RERSLL-- 101
E+ + L R + + EK + LEAE+ + RL+ L+E R+R L
Sbjct: 1763 EMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE 1822
Query: 102 ---RRRSQAAQPLQ------GEA-------------REAARERAERV-------RRRLEE 132
R+R++A + L GEA +EA ER R+ RRRLEE
Sbjct: 1823 DAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEE 1882
Query: 133 -AERHKEDLEQHSRQLQEQWE-ELSSQLFYYGGELQSQKSTEQQLAAQLVTLQN------ 184
A +HK D+E+ QL++ + EL Q L+ ++ E+++ A + +
Sbjct: 1883 QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 1942
Query: 185 --ELELAETKCALQEEKLQQDALQTAEAWAIFQEQTVVLQVRPHSDAKEVQVKVMEAAEE 242
ELEL + + E+ L+ + + AE A Q Q + R +A+E K + A EE
Sbjct: 1943 ELELELGRIR-SNAEDTLR--SKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 1999
Score = 41.6 bits (96), Expect = 0.001
Identities = 40/159 (25%), Positives = 71/159 (44%), Gaps = 10/159 (6%)
Query: 67 QRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPLQGEAREAARERAERV 126
Q K +LE+L + A++ Q+L++ +R++ + + Q EAR E E V
Sbjct: 2511 QEKAKLEQLFQDEVAKA----QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV 2566
Query: 127 RRRLEEAERHKEDLEQHSRQLQEQWEELSSQL-----FYYGGELQSQKSTEQQLAAQLVT 181
RR+ EE ++ ++ Q L E+ + L QL + S++ T Q+AA T
Sbjct: 2567 RRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAA-TKT 2625
Query: 182 LQNELELAETKCALQEEKLQQDALQTAEAWAIFQEQTVV 220
L N + + A E + D L+ + QE ++
Sbjct: 2626 LPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGIL 2664
Score = 41.2 bits (95), Expect = 0.001
Identities = 33/139 (23%), Positives = 62/139 (44%), Gaps = 18/139 (12%)
Query: 52 QELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPL 111
++LL + Q + K L + R +E E L Q QD + + L + + Q +
Sbjct: 2482 EQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQM 2541
Query: 112 QGEAREAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYYGGELQSQKST 171
+ E +R+ +EEA R + + E+ R+ QE+ ++L Q ++
Sbjct: 2542 EQE--------RQRLVASMEEARRRQHEAEEGVRRKQEELQQLE----------QQRRQQ 2583
Query: 172 EQQLAAQLVTLQNELELAE 190
E+ LA + L+ +L+L E
Sbjct: 2584 EELLAEENQRLREQLQLLE 2602
Score = 38.1 bits (87), Expect = 0.012
Identities = 44/165 (26%), Positives = 77/165 (46%), Gaps = 38/165 (23%)
Query: 70 QELEKLMRGLEA---ESESLNQRLQDLSERERSL--LRRRSQAAQPLQGEARE---AARE 121
Q E+++R E E++++ L +L + SL LR +++A QP R+ A+E
Sbjct: 1099 QGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQE 1158
Query: 122 RAERVRRRLEEAERHKEDLEQHSRQLQEQW--------------EELSSQLFYY------ 161
ER+++R E + E + QL E+W E+L QL YY
Sbjct: 1159 VGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADP 1218
Query: 162 -GGELQSQKSTEQQLAAQLVTLQNELELAETKCALQEEKLQQDAL 205
G LQ + ++Q+ A + LA+++ A++E+ Q+ AL
Sbjct: 1219 LGAWLQDARRRQEQIQA--------MPLADSQ-AVREQLRQEQAL 1254
Score = 32.3 bits (72), Expect = 0.67
Identities = 27/110 (24%), Positives = 53/110 (48%), Gaps = 13/110 (11%)
Query: 52 QELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPL 111
Q+ + + Q+ + ++++Q++E+ + L A E +R + E +RR+ + Q L
Sbjct: 2521 QDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEG----VRRKQEELQQL 2576
Query: 112 QGEAR---EAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQL 158
+ + R E E +R+R +L+ E EQH L E +SQ+
Sbjct: 2577 EQQRRQQEELLAEENQRLREQLQLLE------EQHRAALAHSEEVTASQV 2620
Score = 32.0 bits (71), Expect = 0.87
Identities = 45/212 (21%), Positives = 91/212 (42%), Gaps = 34/212 (16%)
Query: 70 QELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPLQGEAREAARERAERVRRR 129
Q LE + + ++E L + + +L ERE+ L++ ++ Q E + +E+ + +
Sbjct: 2432 QTLEIQRQQSDHDAERLREAIAEL-EREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA 2490
Query: 130 LEEAERHKED--------LEQHSRQLQEQWEELSSQLFYYGGELQSQKSTEQQLAAQLVT 181
L+++ ++D +EQ +L++ +++ ++ E Q Q+ +Q +LV
Sbjct: 2491 LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVA 2550
Query: 182 ------------------LQNELELAETKCALQEEKLQQDALQTAEAWAIFQEQTVVLQV 223
Q EL+ E + QEE L ++ + E + +EQ
Sbjct: 2551 SMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQH--RAA 2608
Query: 224 RPHSDAKEVQVKVMEAAEELDAWQSGRELCDG 255
HS+ EV + A + L +GR+ DG
Sbjct: 2609 LAHSE--EVTASQVAATKTL---PNGRDALDG 2635
Score = 30.0 bits (66), Expect = 3.3
Identities = 63/282 (22%), Positives = 105/282 (37%), Gaps = 73/282 (25%)
Query: 52 QELLLQLQKDNRD-GRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLR-------- 102
QE +LQ+D +Q +E + R LEAE + ++L+ +E ER LR
Sbjct: 2340 QEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ---RQLEMSAEAERLKLRVAEMSRAQ 2396
Query: 103 -RRSQAAQPLQGEARE----------AARER-----------------AERVRRRLEEAE 134
R + AQ + +A E A +E+ AER+R + E E
Sbjct: 2397 ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE 2456
Query: 135 RHKEDLEQH----------------------SRQLQEQWEELSSQLFYYGGELQSQKSTE 172
R KE L+Q ++ LQ+ + L LQ ++ E
Sbjct: 2457 REKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL------LQRERFIE 2510
Query: 173 QQLAAQLVTLQNELELAETKCALQEEKLQQDALQTAEAWAIFQEQTVVLQVRPHSDAKEV 232
Q+ A Q+E+ A+ Q+ + QQ + A +E R +A+E
Sbjct: 2511 QEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR-----RRQHEAEEG 2565
Query: 233 QVKVMEAAEELDAWQSGRELCDGQLRGVQYSTESLMEEMARA 274
+ E ++L+ + +E + L+EE RA
Sbjct: 2566 VRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRA 2607
Score = 28.9 bits (63), Expect = 7.4
Identities = 31/113 (27%), Positives = 48/113 (42%), Gaps = 22/113 (19%)
Query: 48 MAATQELLLQLQKDNRDGRQRKQE----LEKLMRGLEA----ESESLNQRLQDLSERERS 99
+ A+ E + Q + +G +RKQE LE+ R E E++ L ++LQ L E+ R+
Sbjct: 2548 LVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRA 2607
Query: 100 LLRRRSQAA--------------QPLQGEAREAARERAERVRRRLEEAERHKE 138
L + L G A EA E + RR A+R +E
Sbjct: 2608 ALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQE 2660
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 61.6 bits (148), Expect = 1e-09
Identities = 73/249 (29%), Positives = 115/249 (46%), Gaps = 19/249 (7%)
Query: 47 AMAATQELLLQLQKDNRDGRQRKQE--------LEKLMRGLEAESESLNQRLQD-LSERE 97
A+ A +EL LQ ++ R RQ + E LE R EAE +S + ++ E
Sbjct: 1538 ALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE 1597
Query: 98 RSLLRRRSQAAQPLQGEAREAARERAERVRRRLEEAERHKEDLEQHSRQ---LQEQWEEL 154
RSL AQ L+ EA A+++AE R R EEAER E + + + L+ Q EE+
Sbjct: 1598 RSLQEEHVAVAQ-LREEAERRAQQQAEAERAR-EEAERELERWQLKANEALRLRLQAEEV 1655
Query: 155 SSQLFYYGGELQSQKSTEQQLAAQLVTLQNELELAETKCALQE-EKLQQDALQTAEAWAI 213
+ Q E + QK E + A+ E + + + A QE EK +Q A TA+
Sbjct: 1656 AQQKSLAQAEAEKQKE-EAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLA 1714
Query: 214 FQEQTVVLQVRPHSDAKEVQVKVMEAAE---ELDAWQSGRELCDGQLRGVQYSTESLMEE 270
+++ + L+ ++ Q+ E A E A R+ + +L V+ E L+
Sbjct: 1715 AEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLAS 1774
Query: 271 MARADRETR 279
ARA+ E+R
Sbjct: 1775 KARAEEESR 1783
Score = 56.2 bits (134), Expect = 4e-08
Identities = 72/261 (27%), Positives = 105/261 (40%), Gaps = 32/261 (12%)
Query: 43 SVSTAMAATQELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQR-LQDLSERERSLL 101
S A A EL L+L GR R + L +AE E+ QR L ER R
Sbjct: 1937 SFEKAAAGKAELELEL------GRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREA 1990
Query: 102 RRRSQAAQPLQGEA---REAARERAERVRRRLEEAERHKEDLEQHS-RQLQEQWEELSSQ 157
R Q + + EA R+AA E ER++ ++EEA R +E EQ S RQLQ E +
Sbjct: 1991 EERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKR 2050
Query: 158 L--------FYYGGELQSQKSTEQQLAAQLVTLQNELELAETKCALQEE-------KLQQ 202
L F + Q + T QQ + L L+ E E A EE + Q
Sbjct: 2051 LQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQ 2110
Query: 203 DALQTAEAWAIFQEQTVVLQVRPHSDA------KEVQVKVMEAAEELDAWQSGRELCDGQ 256
Q EA + Q Q R + A KE + + A+ A ++ D +
Sbjct: 2111 SRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAE 2170
Query: 257 LRGVQYSTESLMEEMARADRE 277
+ + E + + A+ ++E
Sbjct: 2171 MEKHKKFAEQTLRQKAQVEQE 2191
Score = 54.7 bits (130), Expect = 1e-07
Identities = 47/157 (29%), Positives = 77/157 (49%), Gaps = 5/157 (3%)
Query: 52 QELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPL 111
+E L +LQ++ Q++QELE + + AE E L E RS + Q +
Sbjct: 1737 EEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAE 1796
Query: 112 QGEAREAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYYGGELQSQKST 171
G RE A E A R+R EEA+R ++ E+ + + + + E + ++ GE K T
Sbjct: 1797 AGRFRELA-EEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLK-T 1854
Query: 172 EQQLAAQLVTLQNE--LELAETKCALQEEKLQQDALQ 206
E ++A + +NE LAE + A Q +L++ A Q
Sbjct: 1855 EAEIALKEKEAENERLRRLAEDE-AFQRRRLEEQAAQ 1890
Score = 52.4 bits (124), Expect = 6e-07
Identities = 64/274 (23%), Positives = 114/274 (41%), Gaps = 52/274 (18%)
Query: 47 AMAATQELLLQLQKDNRDGRQRKQELEKLMRGLE------AESESLNQRLQDLSERERSL 100
A +E +Q +++ R++ +E E+L + E A++++ ++L+ +E+E +
Sbjct: 2093 AAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAA- 2151
Query: 101 LRRRSQAAQPLQGEAREAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFY 160
RR+QA Q + ++AA E+ ++ E+ R K +EQ L+ Q EE Q
Sbjct: 2152 --RRAQAEQAALRQ-KQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL 2208
Query: 161 YGGELQSQKSTEQQLAAQLVTLQNEL--------ELAETKCAL----------------- 195
ELQ K+ + A Q ++ EL EL++ K +
Sbjct: 2209 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2268
Query: 196 ----QEEKLQQDALQTAEAWAIFQEQTVVLQVRPHSDA----------KEVQVKVMEAAE 241
+ EK++Q A + A QE + Q+ A KE V EA
Sbjct: 2269 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2328
Query: 242 ---ELDAWQSGRELCDGQLRGVQYSTESLMEEMA 272
E + Q +EL Q R +Q E + +++A
Sbjct: 2329 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLA 2362
Score = 50.8 bits (120), Expect = 2e-06
Identities = 61/250 (24%), Positives = 112/250 (44%), Gaps = 35/250 (14%)
Query: 52 QELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPL 111
Q L + ++ RQ ++E E+L R ++ ES+ Q +L+ R ++ + + L
Sbjct: 1480 QALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRAL 1539
Query: 112 QGEAREAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYYGGELQSQKST 171
Q A E R +AE RRL +AE + +RQ+Q E ELQS++++
Sbjct: 1540 Q--ALEELRLQAEEAERRLRQAE------VERARQVQVALETAQRSA---EAELQSKRAS 1588
Query: 172 EQQLAAQLV-TLQNE-------LELAETKCALQ--EEKLQQDALQTAEAWAIFQEQTVVL 221
+ AQL +LQ E E AE + Q E+ +++A + E W + + + L
Sbjct: 1589 FAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRL 1648
Query: 222 QVRPHSDAKEVQVKVMEAAE-----ELDAWQSG---------RELCDGQLRGVQYSTESL 267
+++ A++ + EA + E +A + G REL + +L + E
Sbjct: 1649 RLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGT 1708
Query: 268 MEEMARADRE 277
++ A++E
Sbjct: 1709 AQQRLAAEQE 1718
Score = 48.9 bits (115), Expect = 7e-06
Identities = 63/267 (23%), Positives = 114/267 (42%), Gaps = 57/267 (21%)
Query: 57 QLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSER----ERSLLRRRSQAAQPLQ 112
Q++++ R + +EL KL +EAE+ +L R +D ++R E +++ ++ A L
Sbjct: 2229 QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLS 2288
Query: 113 GEAREAARER---------------------------AERVRRRLEEAERHKEDLEQHSR 145
A+EAAR R A R++ E ++ KE ++ +R
Sbjct: 2289 VAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR 2348
Query: 146 QLQEQWEELSSQL------FYYGGELQSQKSTEQQLAAQLVTLQNELELAETKCALQE-- 197
+LQE E+++ QL F E + Q+ E A+ + L+ E++ + +E
Sbjct: 2349 RLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLR-VAEMSRAQARAEEDA 2407
Query: 198 -----------EKLQQDALQTAEAWAIFQEQTVVLQVRPHSDAKEVQVKVMEAAEELDAW 246
EKL + L T E + Q + Q H DA+ ++ + E E +
Sbjct: 2408 QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH-DAERLREAIAELEREKEKL 2466
Query: 247 QSGRELCDGQLRGVQYST---ESLMEE 270
Q +L QL+ + T E L++E
Sbjct: 2467 QQEAKLL--QLKSEEMQTVQQEQLLQE 2491
Score = 47.8 bits (112), Expect = 2e-05
Identities = 62/265 (23%), Positives = 107/265 (40%), Gaps = 30/265 (11%)
Query: 19 RRSLPPIVTPASRRLGPRGGRHL----GSVSTAMAATQELLLQLQKDNRDGRQRKQELEK 74
+ L P+ +PA + G + + T + L Q K + +R +E E+
Sbjct: 1294 KAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER 1353
Query: 75 LMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPLQGEAREAARERAERVRRRLEEAE 134
L AE ++ E++R L +QA + EA+E + E V RR E A
Sbjct: 1354 LAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA- 1412
Query: 135 RHKEDLEQHSRQLQEQWEELSSQLFYYGGELQSQKSTEQQLAAQLVTLQNELELAETKCA 194
D +Q R +QE+ ++L E + Q Q AA+ L+ E E+ +
Sbjct: 1413 ---VDAQQQKRSIQEELQQLRQ-----SSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ 1464
Query: 195 LQEEKLQQDALQTAEAWAIFQEQTVVLQVRPHSDAKEVQVKVMEAAEELDAWQSGRELCD 254
L+ + Q+ + E A+ + A+E + + +A EE + + R++ D
Sbjct: 1465 LEATERQRGGAE-GELQAL------------RARAEEAEAQKRQAQEEAERLR--RQVQD 1509
Query: 255 GQLRGVQYSTE--SLMEEMARADRE 277
R Q E S ++ A A RE
Sbjct: 1510 ESQRKRQAEVELASRVKAEAEAARE 1534
Score = 45.1 bits (105), Expect = 1e-04
Identities = 69/283 (24%), Positives = 110/283 (38%), Gaps = 64/283 (22%)
Query: 45 STAMAATQELLLQLQKD---------NRDGRQRKQELEKLMRGLEAESESLNQRLQDLS- 94
+T + A E LLQ QK+ D Q Q+L + +G + E+ QR ++S
Sbjct: 2326 ATRLKAEAE-LLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSA 2384
Query: 95 ERERSLLR---------RRSQAAQPLQGEARE----------AARER------------- 122
E ER LR R + AQ + +A E A +E+
Sbjct: 2385 EAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQ 2444
Query: 123 ----AERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYYGGELQSQKSTEQQLAAQ 178
AER+R + E ER KE L+Q ++ LQ + EE+ Q ++QL +
Sbjct: 2445 SDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM-------------QTVQQEQLLQE 2491
Query: 179 LVTLQNELELAETKCALQEEKLQQDALQTAEAWAIFQEQTVVLQVRPHSDAKEVQVKVME 238
LQ L+E LQ E+ + + A+ +FQ++ Q ++ Q E
Sbjct: 2492 TQALQQSF-LSEKDSLLQRERFIEQ--EKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQE 2548
Query: 239 AAEELDAWQSGRELCDGQLRGVQYSTESLME-EMARADRETRL 280
+ + + R GV+ E L + E R +E L
Sbjct: 2549 RQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELL 2591
Score = 43.5 bits (101), Expect = 3e-04
Identities = 70/286 (24%), Positives = 121/286 (42%), Gaps = 53/286 (18%)
Query: 32 RLGPRGGRHLGSVSTAMAATQELLLQLQKDNRDGRQRKQELEKLMRGLEAESES---LNQ 88
RL R G V +LL + Q R++ELE+L R L ES L
Sbjct: 1166 RLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGA 1225
Query: 89 RLQDLSERERSLLRRRSQAAQPLQGEAREAARERAERVRRRLEEAERHKEDLEQ---HSR 145
LQD RRR + Q + +A RE+ + + LEE ERH E +E+ ++
Sbjct: 1226 WLQDA--------RRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAK 1277
Query: 146 QLQEQWEELSSQLFYYGGELQS----------QKSTEQQLA---------AQLVTLQNE- 185
Q ++ QL Y +L+ Q +E + ++L TL ++
Sbjct: 1278 QYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQY 1337
Query: 186 -------LELAETKCALQEEKLQQDALQTAEAWAIFQEQTVVLQVRPHS------DAKEV 232
L E + L E++ ++ + AE A ++Q + + + +AKE+
Sbjct: 1338 IKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKEL 1397
Query: 233 QVKVMEAA---EE--LDAWQSGRELCDGQLRGVQYSTESLMEEMAR 273
Q ++ E EE +DA Q R + + +L+ ++ S+E+ ++ AR
Sbjct: 1398 QQRMQEEVVRREEAAVDAQQQKRSIQE-ELQQLRQSSEAEIQAKAR 1442
Score = 42.0 bits (97), Expect = 8e-04
Identities = 65/240 (27%), Positives = 105/240 (43%), Gaps = 53/240 (22%)
Query: 53 ELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQ------RLQDLSE---RERSLL-- 101
E+ + L R + + EK + LEAE+ + RL+ L+E R+R L
Sbjct: 1767 EMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE 1826
Query: 102 ---RRRSQAAQPLQ------GEA-------------REAARERAERV-------RRRLEE 132
R+R++A + L GEA +EA ER R+ RRRLEE
Sbjct: 1827 DAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEE 1886
Query: 133 -AERHKEDLEQHSRQLQEQWE-ELSSQLFYYGGELQSQKSTEQQLAAQLVTLQN------ 184
A +HK D+E+ QL++ + EL Q L+ ++ E+++ A + +
Sbjct: 1887 QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 1946
Query: 185 --ELELAETKCALQEEKLQQDALQTAEAWAIFQEQTVVLQVRPHSDAKEVQVKVMEAAEE 242
ELEL + + E+ L+ + + AE A Q Q + R +A+E K + A EE
Sbjct: 1947 ELELELGRIR-SNAEDTLR--SKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 2003
Score = 41.6 bits (96), Expect = 0.001
Identities = 40/159 (25%), Positives = 71/159 (44%), Gaps = 10/159 (6%)
Query: 67 QRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPLQGEAREAARERAERV 126
Q K +LE+L + A++ Q+L++ +R++ + + Q EAR E E V
Sbjct: 2515 QEKAKLEQLFQDEVAKA----QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV 2570
Query: 127 RRRLEEAERHKEDLEQHSRQLQEQWEELSSQL-----FYYGGELQSQKSTEQQLAAQLVT 181
RR+ EE ++ ++ Q L E+ + L QL + S++ T Q+AA T
Sbjct: 2571 RRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAA-TKT 2629
Query: 182 LQNELELAETKCALQEEKLQQDALQTAEAWAIFQEQTVV 220
L N + + A E + D L+ + QE ++
Sbjct: 2630 LPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGIL 2668
Score = 41.2 bits (95), Expect = 0.001
Identities = 33/139 (23%), Positives = 62/139 (44%), Gaps = 18/139 (12%)
Query: 52 QELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPL 111
++LL + Q + K L + R +E E L Q QD + + L + + Q +
Sbjct: 2486 EQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQM 2545
Query: 112 QGEAREAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYYGGELQSQKST 171
+ E +R+ +EEA R + + E+ R+ QE+ ++L Q ++
Sbjct: 2546 EQE--------RQRLVASMEEARRRQHEAEEGVRRKQEELQQLE----------QQRRQQ 2587
Query: 172 EQQLAAQLVTLQNELELAE 190
E+ LA + L+ +L+L E
Sbjct: 2588 EELLAEENQRLREQLQLLE 2606
Score = 38.1 bits (87), Expect = 0.012
Identities = 44/165 (26%), Positives = 77/165 (46%), Gaps = 38/165 (23%)
Query: 70 QELEKLMRGLEA---ESESLNQRLQDLSERERSL--LRRRSQAAQPLQGEARE---AARE 121
Q E+++R E E++++ L +L + SL LR +++A QP R+ A+E
Sbjct: 1103 QGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQE 1162
Query: 122 RAERVRRRLEEAERHKEDLEQHSRQLQEQW--------------EELSSQLFYY------ 161
ER+++R E + E + QL E+W E+L QL YY
Sbjct: 1163 VGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADP 1222
Query: 162 -GGELQSQKSTEQQLAAQLVTLQNELELAETKCALQEEKLQQDAL 205
G LQ + ++Q+ A + LA+++ A++E+ Q+ AL
Sbjct: 1223 LGAWLQDARRRQEQIQA--------MPLADSQ-AVREQLRQEQAL 1258
Score = 32.3 bits (72), Expect = 0.67
Identities = 27/110 (24%), Positives = 53/110 (48%), Gaps = 13/110 (11%)
Query: 52 QELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPL 111
Q+ + + Q+ + ++++Q++E+ + L A E +R + E +RR+ + Q L
Sbjct: 2525 QDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEG----VRRKQEELQQL 2580
Query: 112 QGEAR---EAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQL 158
+ + R E E +R+R +L+ E EQH L E +SQ+
Sbjct: 2581 EQQRRQQEELLAEENQRLREQLQLLE------EQHRAALAHSEEVTASQV 2624
Score = 32.0 bits (71), Expect = 0.87
Identities = 45/212 (21%), Positives = 91/212 (42%), Gaps = 34/212 (16%)
Query: 70 QELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPLQGEAREAARERAERVRRR 129
Q LE + + ++E L + + +L ERE+ L++ ++ Q E + +E+ + +
Sbjct: 2436 QTLEIQRQQSDHDAERLREAIAEL-EREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA 2494
Query: 130 LEEAERHKED--------LEQHSRQLQEQWEELSSQLFYYGGELQSQKSTEQQLAAQLVT 181
L+++ ++D +EQ +L++ +++ ++ E Q Q+ +Q +LV
Sbjct: 2495 LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVA 2554
Query: 182 ------------------LQNELELAETKCALQEEKLQQDALQTAEAWAIFQEQTVVLQV 223
Q EL+ E + QEE L ++ + E + +EQ
Sbjct: 2555 SMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQH--RAA 2612
Query: 224 RPHSDAKEVQVKVMEAAEELDAWQSGRELCDG 255
HS+ EV + A + L +GR+ DG
Sbjct: 2613 LAHSE--EVTASQVAATKTL---PNGRDALDG 2639
Score = 30.0 bits (66), Expect = 3.3
Identities = 63/282 (22%), Positives = 105/282 (37%), Gaps = 73/282 (25%)
Query: 52 QELLLQLQKDNRD-GRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLR-------- 102
QE +LQ+D +Q +E + R LEAE + ++L+ +E ER LR
Sbjct: 2344 QEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ---RQLEMSAEAERLKLRVAEMSRAQ 2400
Query: 103 -RRSQAAQPLQGEARE----------AARER-----------------AERVRRRLEEAE 134
R + AQ + +A E A +E+ AER+R + E E
Sbjct: 2401 ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE 2460
Query: 135 RHKEDLEQH----------------------SRQLQEQWEELSSQLFYYGGELQSQKSTE 172
R KE L+Q ++ LQ+ + L LQ ++ E
Sbjct: 2461 REKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL------LQRERFIE 2514
Query: 173 QQLAAQLVTLQNELELAETKCALQEEKLQQDALQTAEAWAIFQEQTVVLQVRPHSDAKEV 232
Q+ A Q+E+ A+ Q+ + QQ + A +E R +A+E
Sbjct: 2515 QEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR-----RRQHEAEEG 2569
Query: 233 QVKVMEAAEELDAWQSGRELCDGQLRGVQYSTESLMEEMARA 274
+ E ++L+ + +E + L+EE RA
Sbjct: 2570 VRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRA 2611
Score = 28.9 bits (63), Expect = 7.4
Identities = 31/113 (27%), Positives = 48/113 (42%), Gaps = 22/113 (19%)
Query: 48 MAATQELLLQLQKDNRDGRQRKQE----LEKLMRGLEA----ESESLNQRLQDLSERERS 99
+ A+ E + Q + +G +RKQE LE+ R E E++ L ++LQ L E+ R+
Sbjct: 2552 LVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRA 2611
Query: 100 LLRRRSQAA--------------QPLQGEAREAARERAERVRRRLEEAERHKE 138
L + L G A EA E + RR A+R +E
Sbjct: 2612 ALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQE 2664
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 61.6 bits (148), Expect = 1e-09
Identities = 73/249 (29%), Positives = 115/249 (46%), Gaps = 19/249 (7%)
Query: 47 AMAATQELLLQLQKDNRDGRQRKQE--------LEKLMRGLEAESESLNQRLQD-LSERE 97
A+ A +EL LQ ++ R RQ + E LE R EAE +S + ++ E
Sbjct: 1534 ALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE 1593
Query: 98 RSLLRRRSQAAQPLQGEAREAARERAERVRRRLEEAERHKEDLEQHSRQ---LQEQWEEL 154
RSL AQ L+ EA A+++AE R R EEAER E + + + L+ Q EE+
Sbjct: 1594 RSLQEEHVAVAQ-LREEAERRAQQQAEAERAR-EEAERELERWQLKANEALRLRLQAEEV 1651
Query: 155 SSQLFYYGGELQSQKSTEQQLAAQLVTLQNELELAETKCALQE-EKLQQDALQTAEAWAI 213
+ Q E + QK E + A+ E + + + A QE EK +Q A TA+
Sbjct: 1652 AQQKSLAQAEAEKQKE-EAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLA 1710
Query: 214 FQEQTVVLQVRPHSDAKEVQVKVMEAAE---ELDAWQSGRELCDGQLRGVQYSTESLMEE 270
+++ + L+ ++ Q+ E A E A R+ + +L V+ E L+
Sbjct: 1711 AEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLAS 1770
Query: 271 MARADRETR 279
ARA+ E+R
Sbjct: 1771 KARAEEESR 1779
Score = 56.2 bits (134), Expect = 4e-08
Identities = 72/261 (27%), Positives = 105/261 (40%), Gaps = 32/261 (12%)
Query: 43 SVSTAMAATQELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQR-LQDLSERERSLL 101
S A A EL L+L GR R + L +AE E+ QR L ER R
Sbjct: 1933 SFEKAAAGKAELELEL------GRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREA 1986
Query: 102 RRRSQAAQPLQGEA---REAARERAERVRRRLEEAERHKEDLEQHS-RQLQEQWEELSSQ 157
R Q + + EA R+AA E ER++ ++EEA R +E EQ S RQLQ E +
Sbjct: 1987 EERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKR 2046
Query: 158 L--------FYYGGELQSQKSTEQQLAAQLVTLQNELELAETKCALQEE-------KLQQ 202
L F + Q + T QQ + L L+ E E A EE + Q
Sbjct: 2047 LQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQ 2106
Query: 203 DALQTAEAWAIFQEQTVVLQVRPHSDA------KEVQVKVMEAAEELDAWQSGRELCDGQ 256
Q EA + Q Q R + A KE + + A+ A ++ D +
Sbjct: 2107 SRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAE 2166
Query: 257 LRGVQYSTESLMEEMARADRE 277
+ + E + + A+ ++E
Sbjct: 2167 MEKHKKFAEQTLRQKAQVEQE 2187
Score = 54.7 bits (130), Expect = 1e-07
Identities = 47/157 (29%), Positives = 77/157 (49%), Gaps = 5/157 (3%)
Query: 52 QELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPL 111
+E L +LQ++ Q++QELE + + AE E L E RS + Q +
Sbjct: 1733 EEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAE 1792
Query: 112 QGEAREAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYYGGELQSQKST 171
G RE A E A R+R EEA+R ++ E+ + + + + E + ++ GE K T
Sbjct: 1793 AGRFRELA-EEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLK-T 1850
Query: 172 EQQLAAQLVTLQNE--LELAETKCALQEEKLQQDALQ 206
E ++A + +NE LAE + A Q +L++ A Q
Sbjct: 1851 EAEIALKEKEAENERLRRLAEDE-AFQRRRLEEQAAQ 1886
Score = 52.4 bits (124), Expect = 6e-07
Identities = 64/274 (23%), Positives = 114/274 (41%), Gaps = 52/274 (18%)
Query: 47 AMAATQELLLQLQKDNRDGRQRKQELEKLMRGLE------AESESLNQRLQDLSERERSL 100
A +E +Q +++ R++ +E E+L + E A++++ ++L+ +E+E +
Sbjct: 2089 AAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAA- 2147
Query: 101 LRRRSQAAQPLQGEAREAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFY 160
RR+QA Q + ++AA E+ ++ E+ R K +EQ L+ Q EE Q
Sbjct: 2148 --RRAQAEQAALRQ-KQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL 2204
Query: 161 YGGELQSQKSTEQQLAAQLVTLQNEL--------ELAETKCAL----------------- 195
ELQ K+ + A Q ++ EL EL++ K +
Sbjct: 2205 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2264
Query: 196 ----QEEKLQQDALQTAEAWAIFQEQTVVLQVRPHSDA----------KEVQVKVMEAAE 241
+ EK++Q A + A QE + Q+ A KE V EA
Sbjct: 2265 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2324
Query: 242 ---ELDAWQSGRELCDGQLRGVQYSTESLMEEMA 272
E + Q +EL Q R +Q E + +++A
Sbjct: 2325 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLA 2358
Score = 50.8 bits (120), Expect = 2e-06
Identities = 61/250 (24%), Positives = 112/250 (44%), Gaps = 35/250 (14%)
Query: 52 QELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPL 111
Q L + ++ RQ ++E E+L R ++ ES+ Q +L+ R ++ + + L
Sbjct: 1476 QALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRAL 1535
Query: 112 QGEAREAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYYGGELQSQKST 171
Q A E R +AE RRL +AE + +RQ+Q E ELQS++++
Sbjct: 1536 Q--ALEELRLQAEEAERRLRQAE------VERARQVQVALETAQRSA---EAELQSKRAS 1584
Query: 172 EQQLAAQLV-TLQNE-------LELAETKCALQ--EEKLQQDALQTAEAWAIFQEQTVVL 221
+ AQL +LQ E E AE + Q E+ +++A + E W + + + L
Sbjct: 1585 FAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRL 1644
Query: 222 QVRPHSDAKEVQVKVMEAAE-----ELDAWQSG---------RELCDGQLRGVQYSTESL 267
+++ A++ + EA + E +A + G REL + +L + E
Sbjct: 1645 RLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGT 1704
Query: 268 MEEMARADRE 277
++ A++E
Sbjct: 1705 AQQRLAAEQE 1714
Score = 48.9 bits (115), Expect = 7e-06
Identities = 63/267 (23%), Positives = 114/267 (42%), Gaps = 57/267 (21%)
Query: 57 QLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSER----ERSLLRRRSQAAQPLQ 112
Q++++ R + +EL KL +EAE+ +L R +D ++R E +++ ++ A L
Sbjct: 2225 QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLS 2284
Query: 113 GEAREAARER---------------------------AERVRRRLEEAERHKEDLEQHSR 145
A+EAAR R A R++ E ++ KE ++ +R
Sbjct: 2285 VAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR 2344
Query: 146 QLQEQWEELSSQL------FYYGGELQSQKSTEQQLAAQLVTLQNELELAETKCALQE-- 197
+LQE E+++ QL F E + Q+ E A+ + L+ E++ + +E
Sbjct: 2345 RLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLR-VAEMSRAQARAEEDA 2403
Query: 198 -----------EKLQQDALQTAEAWAIFQEQTVVLQVRPHSDAKEVQVKVMEAAEELDAW 246
EKL + L T E + Q + Q H DA+ ++ + E E +
Sbjct: 2404 QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH-DAERLREAIAELEREKEKL 2462
Query: 247 QSGRELCDGQLRGVQYST---ESLMEE 270
Q +L QL+ + T E L++E
Sbjct: 2463 QQEAKLL--QLKSEEMQTVQQEQLLQE 2487
Score = 47.8 bits (112), Expect = 2e-05
Identities = 62/265 (23%), Positives = 107/265 (40%), Gaps = 30/265 (11%)
Query: 19 RRSLPPIVTPASRRLGPRGGRHL----GSVSTAMAATQELLLQLQKDNRDGRQRKQELEK 74
+ L P+ +PA + G + + T + L Q K + +R +E E+
Sbjct: 1290 KAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER 1349
Query: 75 LMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPLQGEAREAARERAERVRRRLEEAE 134
L AE ++ E++R L +QA + EA+E + E V RR E A
Sbjct: 1350 LAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA- 1408
Query: 135 RHKEDLEQHSRQLQEQWEELSSQLFYYGGELQSQKSTEQQLAAQLVTLQNELELAETKCA 194
D +Q R +QE+ ++L E + Q Q AA+ L+ E E+ +
Sbjct: 1409 ---VDAQQQKRSIQEELQQLRQ-----SSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ 1460
Query: 195 LQEEKLQQDALQTAEAWAIFQEQTVVLQVRPHSDAKEVQVKVMEAAEELDAWQSGRELCD 254
L+ + Q+ + E A+ + A+E + + +A EE + + R++ D
Sbjct: 1461 LEATERQRGGAE-GELQAL------------RARAEEAEAQKRQAQEEAERLR--RQVQD 1505
Query: 255 GQLRGVQYSTE--SLMEEMARADRE 277
R Q E S ++ A A RE
Sbjct: 1506 ESQRKRQAEVELASRVKAEAEAARE 1530
Score = 45.1 bits (105), Expect = 1e-04
Identities = 69/283 (24%), Positives = 110/283 (38%), Gaps = 64/283 (22%)
Query: 45 STAMAATQELLLQLQKD---------NRDGRQRKQELEKLMRGLEAESESLNQRLQDLS- 94
+T + A E LLQ QK+ D Q Q+L + +G + E+ QR ++S
Sbjct: 2322 ATRLKAEAE-LLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSA 2380
Query: 95 ERERSLLR---------RRSQAAQPLQGEARE----------AARER------------- 122
E ER LR R + AQ + +A E A +E+
Sbjct: 2381 EAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQ 2440
Query: 123 ----AERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYYGGELQSQKSTEQQLAAQ 178
AER+R + E ER KE L+Q ++ LQ + EE+ Q ++QL +
Sbjct: 2441 SDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM-------------QTVQQEQLLQE 2487
Query: 179 LVTLQNELELAETKCALQEEKLQQDALQTAEAWAIFQEQTVVLQVRPHSDAKEVQVKVME 238
LQ L+E LQ E+ + + A+ +FQ++ Q ++ Q E
Sbjct: 2488 TQALQQSF-LSEKDSLLQRERFIEQ--EKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQE 2544
Query: 239 AAEELDAWQSGRELCDGQLRGVQYSTESLME-EMARADRETRL 280
+ + + R GV+ E L + E R +E L
Sbjct: 2545 RQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELL 2587
Score = 43.5 bits (101), Expect = 3e-04
Identities = 70/286 (24%), Positives = 121/286 (42%), Gaps = 53/286 (18%)
Query: 32 RLGPRGGRHLGSVSTAMAATQELLLQLQKDNRDGRQRKQELEKLMRGLEAESES---LNQ 88
RL R G V +LL + Q R++ELE+L R L ES L
Sbjct: 1162 RLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGA 1221
Query: 89 RLQDLSERERSLLRRRSQAAQPLQGEAREAARERAERVRRRLEEAERHKEDLEQ---HSR 145
LQD RRR + Q + +A RE+ + + LEE ERH E +E+ ++
Sbjct: 1222 WLQDA--------RRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAK 1273
Query: 146 QLQEQWEELSSQLFYYGGELQS----------QKSTEQQLA---------AQLVTLQNE- 185
Q ++ QL Y +L+ Q +E + ++L TL ++
Sbjct: 1274 QYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQY 1333
Query: 186 -------LELAETKCALQEEKLQQDALQTAEAWAIFQEQTVVLQVRPHS------DAKEV 232
L E + L E++ ++ + AE A ++Q + + + +AKE+
Sbjct: 1334 IKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKEL 1393
Query: 233 QVKVMEAA---EE--LDAWQSGRELCDGQLRGVQYSTESLMEEMAR 273
Q ++ E EE +DA Q R + + +L+ ++ S+E+ ++ AR
Sbjct: 1394 QQRMQEEVVRREEAAVDAQQQKRSIQE-ELQQLRQSSEAEIQAKAR 1438
Score = 42.0 bits (97), Expect = 8e-04
Identities = 65/240 (27%), Positives = 105/240 (43%), Gaps = 53/240 (22%)
Query: 53 ELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQ------RLQDLSE---RERSLL-- 101
E+ + L R + + EK + LEAE+ + RL+ L+E R+R L
Sbjct: 1763 EMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE 1822
Query: 102 ---RRRSQAAQPLQ------GEA-------------REAARERAERV-------RRRLEE 132
R+R++A + L GEA +EA ER R+ RRRLEE
Sbjct: 1823 DAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEE 1882
Query: 133 -AERHKEDLEQHSRQLQEQWE-ELSSQLFYYGGELQSQKSTEQQLAAQLVTLQN------ 184
A +HK D+E+ QL++ + EL Q L+ ++ E+++ A + +
Sbjct: 1883 QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 1942
Query: 185 --ELELAETKCALQEEKLQQDALQTAEAWAIFQEQTVVLQVRPHSDAKEVQVKVMEAAEE 242
ELEL + + E+ L+ + + AE A Q Q + R +A+E K + A EE
Sbjct: 1943 ELELELGRIR-SNAEDTLR--SKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 1999
Score = 41.6 bits (96), Expect = 0.001
Identities = 40/159 (25%), Positives = 71/159 (44%), Gaps = 10/159 (6%)
Query: 67 QRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPLQGEAREAARERAERV 126
Q K +LE+L + A++ Q+L++ +R++ + + Q EAR E E V
Sbjct: 2511 QEKAKLEQLFQDEVAKA----QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV 2566
Query: 127 RRRLEEAERHKEDLEQHSRQLQEQWEELSSQL-----FYYGGELQSQKSTEQQLAAQLVT 181
RR+ EE ++ ++ Q L E+ + L QL + S++ T Q+AA T
Sbjct: 2567 RRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAA-TKT 2625
Query: 182 LQNELELAETKCALQEEKLQQDALQTAEAWAIFQEQTVV 220
L N + + A E + D L+ + QE ++
Sbjct: 2626 LPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGIL 2664
Score = 41.2 bits (95), Expect = 0.001
Identities = 33/139 (23%), Positives = 62/139 (44%), Gaps = 18/139 (12%)
Query: 52 QELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPL 111
++LL + Q + K L + R +E E L Q QD + + L + + Q +
Sbjct: 2482 EQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQM 2541
Query: 112 QGEAREAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYYGGELQSQKST 171
+ E +R+ +EEA R + + E+ R+ QE+ ++L Q ++
Sbjct: 2542 EQE--------RQRLVASMEEARRRQHEAEEGVRRKQEELQQLE----------QQRRQQ 2583
Query: 172 EQQLAAQLVTLQNELELAE 190
E+ LA + L+ +L+L E
Sbjct: 2584 EELLAEENQRLREQLQLLE 2602
Score = 38.1 bits (87), Expect = 0.012
Identities = 44/165 (26%), Positives = 77/165 (46%), Gaps = 38/165 (23%)
Query: 70 QELEKLMRGLEA---ESESLNQRLQDLSERERSL--LRRRSQAAQPLQGEARE---AARE 121
Q E+++R E E++++ L +L + SL LR +++A QP R+ A+E
Sbjct: 1099 QGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQE 1158
Query: 122 RAERVRRRLEEAERHKEDLEQHSRQLQEQW--------------EELSSQLFYY------ 161
ER+++R E + E + QL E+W E+L QL YY
Sbjct: 1159 VGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADP 1218
Query: 162 -GGELQSQKSTEQQLAAQLVTLQNELELAETKCALQEEKLQQDAL 205
G LQ + ++Q+ A + LA+++ A++E+ Q+ AL
Sbjct: 1219 LGAWLQDARRRQEQIQA--------MPLADSQ-AVREQLRQEQAL 1254
Score = 32.3 bits (72), Expect = 0.67
Identities = 27/110 (24%), Positives = 53/110 (48%), Gaps = 13/110 (11%)
Query: 52 QELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPL 111
Q+ + + Q+ + ++++Q++E+ + L A E +R + E +RR+ + Q L
Sbjct: 2521 QDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEG----VRRKQEELQQL 2576
Query: 112 QGEAR---EAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQL 158
+ + R E E +R+R +L+ E EQH L E +SQ+
Sbjct: 2577 EQQRRQQEELLAEENQRLREQLQLLE------EQHRAALAHSEEVTASQV 2620
Score = 32.0 bits (71), Expect = 0.87
Identities = 45/212 (21%), Positives = 91/212 (42%), Gaps = 34/212 (16%)
Query: 70 QELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPLQGEAREAARERAERVRRR 129
Q LE + + ++E L + + +L ERE+ L++ ++ Q E + +E+ + +
Sbjct: 2432 QTLEIQRQQSDHDAERLREAIAEL-EREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA 2490
Query: 130 LEEAERHKED--------LEQHSRQLQEQWEELSSQLFYYGGELQSQKSTEQQLAAQLVT 181
L+++ ++D +EQ +L++ +++ ++ E Q Q+ +Q +LV
Sbjct: 2491 LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVA 2550
Query: 182 ------------------LQNELELAETKCALQEEKLQQDALQTAEAWAIFQEQTVVLQV 223
Q EL+ E + QEE L ++ + E + +EQ
Sbjct: 2551 SMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQH--RAA 2608
Query: 224 RPHSDAKEVQVKVMEAAEELDAWQSGRELCDG 255
HS+ EV + A + L +GR+ DG
Sbjct: 2609 LAHSE--EVTASQVAATKTL---PNGRDALDG 2635
Score = 30.0 bits (66), Expect = 3.3
Identities = 63/282 (22%), Positives = 105/282 (37%), Gaps = 73/282 (25%)
Query: 52 QELLLQLQKDNRD-GRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLR-------- 102
QE +LQ+D +Q +E + R LEAE + ++L+ +E ER LR
Sbjct: 2340 QEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ---RQLEMSAEAERLKLRVAEMSRAQ 2396
Query: 103 -RRSQAAQPLQGEARE----------AARER-----------------AERVRRRLEEAE 134
R + AQ + +A E A +E+ AER+R + E E
Sbjct: 2397 ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE 2456
Query: 135 RHKEDLEQH----------------------SRQLQEQWEELSSQLFYYGGELQSQKSTE 172
R KE L+Q ++ LQ+ + L LQ ++ E
Sbjct: 2457 REKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL------LQRERFIE 2510
Query: 173 QQLAAQLVTLQNELELAETKCALQEEKLQQDALQTAEAWAIFQEQTVVLQVRPHSDAKEV 232
Q+ A Q+E+ A+ Q+ + QQ + A +E R +A+E
Sbjct: 2511 QEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR-----RRQHEAEEG 2565
Query: 233 QVKVMEAAEELDAWQSGRELCDGQLRGVQYSTESLMEEMARA 274
+ E ++L+ + +E + L+EE RA
Sbjct: 2566 VRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRA 2607
Score = 28.9 bits (63), Expect = 7.4
Identities = 31/113 (27%), Positives = 48/113 (42%), Gaps = 22/113 (19%)
Query: 48 MAATQELLLQLQKDNRDGRQRKQE----LEKLMRGLEA----ESESLNQRLQDLSERERS 99
+ A+ E + Q + +G +RKQE LE+ R E E++ L ++LQ L E+ R+
Sbjct: 2548 LVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRA 2607
Query: 100 LLRRRSQAA--------------QPLQGEAREAARERAERVRRRLEEAERHKE 138
L + L G A EA E + RR A+R +E
Sbjct: 2608 ALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQE 2660
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 61.6 bits (148), Expect = 1e-09
Identities = 73/249 (29%), Positives = 115/249 (46%), Gaps = 19/249 (7%)
Query: 47 AMAATQELLLQLQKDNRDGRQRKQE--------LEKLMRGLEAESESLNQRLQD-LSERE 97
A+ A +EL LQ ++ R RQ + E LE R EAE +S + ++ E
Sbjct: 1502 ALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE 1561
Query: 98 RSLLRRRSQAAQPLQGEAREAARERAERVRRRLEEAERHKEDLEQHSRQ---LQEQWEEL 154
RSL AQ L+ EA A+++AE R R EEAER E + + + L+ Q EE+
Sbjct: 1562 RSLQEEHVAVAQ-LREEAERRAQQQAEAERAR-EEAERELERWQLKANEALRLRLQAEEV 1619
Query: 155 SSQLFYYGGELQSQKSTEQQLAAQLVTLQNELELAETKCALQE-EKLQQDALQTAEAWAI 213
+ Q E + QK E + A+ E + + + A QE EK +Q A TA+
Sbjct: 1620 AQQKSLAQAEAEKQKE-EAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLA 1678
Query: 214 FQEQTVVLQVRPHSDAKEVQVKVMEAAE---ELDAWQSGRELCDGQLRGVQYSTESLMEE 270
+++ + L+ ++ Q+ E A E A R+ + +L V+ E L+
Sbjct: 1679 AEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLAS 1738
Query: 271 MARADRETR 279
ARA+ E+R
Sbjct: 1739 KARAEEESR 1747
Score = 56.2 bits (134), Expect = 4e-08
Identities = 72/261 (27%), Positives = 105/261 (40%), Gaps = 32/261 (12%)
Query: 43 SVSTAMAATQELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQR-LQDLSERERSLL 101
S A A EL L+L GR R + L +AE E+ QR L ER R
Sbjct: 1901 SFEKAAAGKAELELEL------GRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREA 1954
Query: 102 RRRSQAAQPLQGEA---REAARERAERVRRRLEEAERHKEDLEQHS-RQLQEQWEELSSQ 157
R Q + + EA R+AA E ER++ ++EEA R +E EQ S RQLQ E +
Sbjct: 1955 EERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKR 2014
Query: 158 L--------FYYGGELQSQKSTEQQLAAQLVTLQNELELAETKCALQEE-------KLQQ 202
L F + Q + T QQ + L L+ E E A EE + Q
Sbjct: 2015 LQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQ 2074
Query: 203 DALQTAEAWAIFQEQTVVLQVRPHSDA------KEVQVKVMEAAEELDAWQSGRELCDGQ 256
Q EA + Q Q R + A KE + + A+ A ++ D +
Sbjct: 2075 SRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAE 2134
Query: 257 LRGVQYSTESLMEEMARADRE 277
+ + E + + A+ ++E
Sbjct: 2135 MEKHKKFAEQTLRQKAQVEQE 2155
Score = 54.7 bits (130), Expect = 1e-07
Identities = 47/157 (29%), Positives = 77/157 (49%), Gaps = 5/157 (3%)
Query: 52 QELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPL 111
+E L +LQ++ Q++QELE + + AE E L E RS + Q +
Sbjct: 1701 EEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAE 1760
Query: 112 QGEAREAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYYGGELQSQKST 171
G RE A E A R+R EEA+R ++ E+ + + + + E + ++ GE K T
Sbjct: 1761 AGRFRELA-EEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLK-T 1818
Query: 172 EQQLAAQLVTLQNE--LELAETKCALQEEKLQQDALQ 206
E ++A + +NE LAE + A Q +L++ A Q
Sbjct: 1819 EAEIALKEKEAENERLRRLAEDE-AFQRRRLEEQAAQ 1854
Score = 52.4 bits (124), Expect = 6e-07
Identities = 64/274 (23%), Positives = 114/274 (41%), Gaps = 52/274 (18%)
Query: 47 AMAATQELLLQLQKDNRDGRQRKQELEKLMRGLE------AESESLNQRLQDLSERERSL 100
A +E +Q +++ R++ +E E+L + E A++++ ++L+ +E+E +
Sbjct: 2057 AAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAA- 2115
Query: 101 LRRRSQAAQPLQGEAREAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFY 160
RR+QA Q + ++AA E+ ++ E+ R K +EQ L+ Q EE Q
Sbjct: 2116 --RRAQAEQAALRQ-KQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL 2172
Query: 161 YGGELQSQKSTEQQLAAQLVTLQNEL--------ELAETKCAL----------------- 195
ELQ K+ + A Q ++ EL EL++ K +
Sbjct: 2173 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2232
Query: 196 ----QEEKLQQDALQTAEAWAIFQEQTVVLQVRPHSDA----------KEVQVKVMEAAE 241
+ EK++Q A + A QE + Q+ A KE V EA
Sbjct: 2233 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2292
Query: 242 ---ELDAWQSGRELCDGQLRGVQYSTESLMEEMA 272
E + Q +EL Q R +Q E + +++A
Sbjct: 2293 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLA 2326
Score = 50.8 bits (120), Expect = 2e-06
Identities = 61/250 (24%), Positives = 112/250 (44%), Gaps = 35/250 (14%)
Query: 52 QELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPL 111
Q L + ++ RQ ++E E+L R ++ ES+ Q +L+ R ++ + + L
Sbjct: 1444 QALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRAL 1503
Query: 112 QGEAREAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYYGGELQSQKST 171
Q A E R +AE RRL +AE + +RQ+Q E ELQS++++
Sbjct: 1504 Q--ALEELRLQAEEAERRLRQAE------VERARQVQVALETAQRSA---EAELQSKRAS 1552
Query: 172 EQQLAAQLV-TLQNE-------LELAETKCALQ--EEKLQQDALQTAEAWAIFQEQTVVL 221
+ AQL +LQ E E AE + Q E+ +++A + E W + + + L
Sbjct: 1553 FAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRL 1612
Query: 222 QVRPHSDAKEVQVKVMEAAE-----ELDAWQSG---------RELCDGQLRGVQYSTESL 267
+++ A++ + EA + E +A + G REL + +L + E
Sbjct: 1613 RLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGT 1672
Query: 268 MEEMARADRE 277
++ A++E
Sbjct: 1673 AQQRLAAEQE 1682
Score = 48.9 bits (115), Expect = 7e-06
Identities = 63/267 (23%), Positives = 114/267 (42%), Gaps = 57/267 (21%)
Query: 57 QLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSER----ERSLLRRRSQAAQPLQ 112
Q++++ R + +EL KL +EAE+ +L R +D ++R E +++ ++ A L
Sbjct: 2193 QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLS 2252
Query: 113 GEAREAARER---------------------------AERVRRRLEEAERHKEDLEQHSR 145
A+EAAR R A R++ E ++ KE ++ +R
Sbjct: 2253 VAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR 2312
Query: 146 QLQEQWEELSSQL------FYYGGELQSQKSTEQQLAAQLVTLQNELELAETKCALQE-- 197
+LQE E+++ QL F E + Q+ E A+ + L+ E++ + +E
Sbjct: 2313 RLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLR-VAEMSRAQARAEEDA 2371
Query: 198 -----------EKLQQDALQTAEAWAIFQEQTVVLQVRPHSDAKEVQVKVMEAAEELDAW 246
EKL + L T E + Q + Q H DA+ ++ + E E +
Sbjct: 2372 QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH-DAERLREAIAELEREKEKL 2430
Query: 247 QSGRELCDGQLRGVQYST---ESLMEE 270
Q +L QL+ + T E L++E
Sbjct: 2431 QQEAKLL--QLKSEEMQTVQQEQLLQE 2455
Score = 47.8 bits (112), Expect = 2e-05
Identities = 62/265 (23%), Positives = 107/265 (40%), Gaps = 30/265 (11%)
Query: 19 RRSLPPIVTPASRRLGPRGGRHL----GSVSTAMAATQELLLQLQKDNRDGRQRKQELEK 74
+ L P+ +PA + G + + T + L Q K + +R +E E+
Sbjct: 1258 KAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER 1317
Query: 75 LMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPLQGEAREAARERAERVRRRLEEAE 134
L AE ++ E++R L +QA + EA+E + E V RR E A
Sbjct: 1318 LAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA- 1376
Query: 135 RHKEDLEQHSRQLQEQWEELSSQLFYYGGELQSQKSTEQQLAAQLVTLQNELELAETKCA 194
D +Q R +QE+ ++L E + Q Q AA+ L+ E E+ +
Sbjct: 1377 ---VDAQQQKRSIQEELQQLRQ-----SSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ 1428
Query: 195 LQEEKLQQDALQTAEAWAIFQEQTVVLQVRPHSDAKEVQVKVMEAAEELDAWQSGRELCD 254
L+ + Q+ + E A+ + A+E + + +A EE + + R++ D
Sbjct: 1429 LEATERQRGGAE-GELQAL------------RARAEEAEAQKRQAQEEAERLR--RQVQD 1473
Query: 255 GQLRGVQYSTE--SLMEEMARADRE 277
R Q E S ++ A A RE
Sbjct: 1474 ESQRKRQAEVELASRVKAEAEAARE 1498
Score = 45.1 bits (105), Expect = 1e-04
Identities = 69/283 (24%), Positives = 110/283 (38%), Gaps = 64/283 (22%)
Query: 45 STAMAATQELLLQLQKD---------NRDGRQRKQELEKLMRGLEAESESLNQRLQDLS- 94
+T + A E LLQ QK+ D Q Q+L + +G + E+ QR ++S
Sbjct: 2290 ATRLKAEAE-LLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSA 2348
Query: 95 ERERSLLR---------RRSQAAQPLQGEARE----------AARER------------- 122
E ER LR R + AQ + +A E A +E+
Sbjct: 2349 EAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQ 2408
Query: 123 ----AERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYYGGELQSQKSTEQQLAAQ 178
AER+R + E ER KE L+Q ++ LQ + EE+ Q ++QL +
Sbjct: 2409 SDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM-------------QTVQQEQLLQE 2455
Query: 179 LVTLQNELELAETKCALQEEKLQQDALQTAEAWAIFQEQTVVLQVRPHSDAKEVQVKVME 238
LQ L+E LQ E+ + + A+ +FQ++ Q ++ Q E
Sbjct: 2456 TQALQQSF-LSEKDSLLQRERFIEQ--EKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQE 2512
Query: 239 AAEELDAWQSGRELCDGQLRGVQYSTESLME-EMARADRETRL 280
+ + + R GV+ E L + E R +E L
Sbjct: 2513 RQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELL 2555
Score = 43.5 bits (101), Expect = 3e-04
Identities = 70/286 (24%), Positives = 121/286 (42%), Gaps = 53/286 (18%)
Query: 32 RLGPRGGRHLGSVSTAMAATQELLLQLQKDNRDGRQRKQELEKLMRGLEAESES---LNQ 88
RL R G V +LL + Q R++ELE+L R L ES L
Sbjct: 1130 RLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGA 1189
Query: 89 RLQDLSERERSLLRRRSQAAQPLQGEAREAARERAERVRRRLEEAERHKEDLEQ---HSR 145
LQD RRR + Q + +A RE+ + + LEE ERH E +E+ ++
Sbjct: 1190 WLQDA--------RRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAK 1241
Query: 146 QLQEQWEELSSQLFYYGGELQS----------QKSTEQQLA---------AQLVTLQNE- 185
Q ++ QL Y +L+ Q +E + ++L TL ++
Sbjct: 1242 QYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQY 1301
Query: 186 -------LELAETKCALQEEKLQQDALQTAEAWAIFQEQTVVLQVRPHS------DAKEV 232
L E + L E++ ++ + AE A ++Q + + + +AKE+
Sbjct: 1302 IKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKEL 1361
Query: 233 QVKVMEAA---EE--LDAWQSGRELCDGQLRGVQYSTESLMEEMAR 273
Q ++ E EE +DA Q R + + +L+ ++ S+E+ ++ AR
Sbjct: 1362 QQRMQEEVVRREEAAVDAQQQKRSIQE-ELQQLRQSSEAEIQAKAR 1406
Score = 42.0 bits (97), Expect = 8e-04
Identities = 65/240 (27%), Positives = 105/240 (43%), Gaps = 53/240 (22%)
Query: 53 ELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQ------RLQDLSE---RERSLL-- 101
E+ + L R + + EK + LEAE+ + RL+ L+E R+R L
Sbjct: 1731 EMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE 1790
Query: 102 ---RRRSQAAQPLQ------GEA-------------REAARERAERV-------RRRLEE 132
R+R++A + L GEA +EA ER R+ RRRLEE
Sbjct: 1791 DAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEE 1850
Query: 133 -AERHKEDLEQHSRQLQEQWE-ELSSQLFYYGGELQSQKSTEQQLAAQLVTLQN------ 184
A +HK D+E+ QL++ + EL Q L+ ++ E+++ A + +
Sbjct: 1851 QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 1910
Query: 185 --ELELAETKCALQEEKLQQDALQTAEAWAIFQEQTVVLQVRPHSDAKEVQVKVMEAAEE 242
ELEL + + E+ L+ + + AE A Q Q + R +A+E K + A EE
Sbjct: 1911 ELELELGRIR-SNAEDTLR--SKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 1967
Score = 41.6 bits (96), Expect = 0.001
Identities = 40/159 (25%), Positives = 71/159 (44%), Gaps = 10/159 (6%)
Query: 67 QRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPLQGEAREAARERAERV 126
Q K +LE+L + A++ Q+L++ +R++ + + Q EAR E E V
Sbjct: 2479 QEKAKLEQLFQDEVAKA----QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV 2534
Query: 127 RRRLEEAERHKEDLEQHSRQLQEQWEELSSQL-----FYYGGELQSQKSTEQQLAAQLVT 181
RR+ EE ++ ++ Q L E+ + L QL + S++ T Q+AA T
Sbjct: 2535 RRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAA-TKT 2593
Query: 182 LQNELELAETKCALQEEKLQQDALQTAEAWAIFQEQTVV 220
L N + + A E + D L+ + QE ++
Sbjct: 2594 LPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGIL 2632
Score = 41.2 bits (95), Expect = 0.001
Identities = 33/139 (23%), Positives = 62/139 (44%), Gaps = 18/139 (12%)
Query: 52 QELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPL 111
++LL + Q + K L + R +E E L Q QD + + L + + Q +
Sbjct: 2450 EQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQM 2509
Query: 112 QGEAREAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYYGGELQSQKST 171
+ E +R+ +EEA R + + E+ R+ QE+ ++L Q ++
Sbjct: 2510 EQE--------RQRLVASMEEARRRQHEAEEGVRRKQEELQQLE----------QQRRQQ 2551
Query: 172 EQQLAAQLVTLQNELELAE 190
E+ LA + L+ +L+L E
Sbjct: 2552 EELLAEENQRLREQLQLLE 2570
Score = 38.1 bits (87), Expect = 0.012
Identities = 44/165 (26%), Positives = 77/165 (46%), Gaps = 38/165 (23%)
Query: 70 QELEKLMRGLEA---ESESLNQRLQDLSERERSL--LRRRSQAAQPLQGEARE---AARE 121
Q E+++R E E++++ L +L + SL LR +++A QP R+ A+E
Sbjct: 1067 QGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQE 1126
Query: 122 RAERVRRRLEEAERHKEDLEQHSRQLQEQW--------------EELSSQLFYY------ 161
ER+++R E + E + QL E+W E+L QL YY
Sbjct: 1127 VGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADP 1186
Query: 162 -GGELQSQKSTEQQLAAQLVTLQNELELAETKCALQEEKLQQDAL 205
G LQ + ++Q+ A + LA+++ A++E+ Q+ AL
Sbjct: 1187 LGAWLQDARRRQEQIQA--------MPLADSQ-AVREQLRQEQAL 1222
Score = 32.3 bits (72), Expect = 0.67
Identities = 27/110 (24%), Positives = 53/110 (48%), Gaps = 13/110 (11%)
Query: 52 QELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPL 111
Q+ + + Q+ + ++++Q++E+ + L A E +R + E +RR+ + Q L
Sbjct: 2489 QDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEG----VRRKQEELQQL 2544
Query: 112 QGEAR---EAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQL 158
+ + R E E +R+R +L+ E EQH L E +SQ+
Sbjct: 2545 EQQRRQQEELLAEENQRLREQLQLLE------EQHRAALAHSEEVTASQV 2588
Score = 32.0 bits (71), Expect = 0.87
Identities = 45/212 (21%), Positives = 91/212 (42%), Gaps = 34/212 (16%)
Query: 70 QELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPLQGEAREAARERAERVRRR 129
Q LE + + ++E L + + +L ERE+ L++ ++ Q E + +E+ + +
Sbjct: 2400 QTLEIQRQQSDHDAERLREAIAEL-EREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA 2458
Query: 130 LEEAERHKED--------LEQHSRQLQEQWEELSSQLFYYGGELQSQKSTEQQLAAQLVT 181
L+++ ++D +EQ +L++ +++ ++ E Q Q+ +Q +LV
Sbjct: 2459 LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVA 2518
Query: 182 ------------------LQNELELAETKCALQEEKLQQDALQTAEAWAIFQEQTVVLQV 223
Q EL+ E + QEE L ++ + E + +EQ
Sbjct: 2519 SMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQH--RAA 2576
Query: 224 RPHSDAKEVQVKVMEAAEELDAWQSGRELCDG 255
HS+ EV + A + L +GR+ DG
Sbjct: 2577 LAHSE--EVTASQVAATKTL---PNGRDALDG 2603
Score = 30.0 bits (66), Expect = 3.3
Identities = 63/282 (22%), Positives = 105/282 (37%), Gaps = 73/282 (25%)
Query: 52 QELLLQLQKDNRD-GRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLR-------- 102
QE +LQ+D +Q +E + R LEAE + ++L+ +E ER LR
Sbjct: 2308 QEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ---RQLEMSAEAERLKLRVAEMSRAQ 2364
Query: 103 -RRSQAAQPLQGEARE----------AARER-----------------AERVRRRLEEAE 134
R + AQ + +A E A +E+ AER+R + E E
Sbjct: 2365 ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE 2424
Query: 135 RHKEDLEQH----------------------SRQLQEQWEELSSQLFYYGGELQSQKSTE 172
R KE L+Q ++ LQ+ + L LQ ++ E
Sbjct: 2425 REKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL------LQRERFIE 2478
Query: 173 QQLAAQLVTLQNELELAETKCALQEEKLQQDALQTAEAWAIFQEQTVVLQVRPHSDAKEV 232
Q+ A Q+E+ A+ Q+ + QQ + A +E R +A+E
Sbjct: 2479 QEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR-----RRQHEAEEG 2533
Query: 233 QVKVMEAAEELDAWQSGRELCDGQLRGVQYSTESLMEEMARA 274
+ E ++L+ + +E + L+EE RA
Sbjct: 2534 VRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRA 2575
Score = 28.9 bits (63), Expect = 7.4
Identities = 31/113 (27%), Positives = 48/113 (42%), Gaps = 22/113 (19%)
Query: 48 MAATQELLLQLQKDNRDGRQRKQE----LEKLMRGLEA----ESESLNQRLQDLSERERS 99
+ A+ E + Q + +G +RKQE LE+ R E E++ L ++LQ L E+ R+
Sbjct: 2516 LVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRA 2575
Query: 100 LLRRRSQAA--------------QPLQGEAREAARERAERVRRRLEEAERHKE 138
L + L G A EA E + RR A+R +E
Sbjct: 2576 ALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQE 2628
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 61.6 bits (148), Expect = 1e-09
Identities = 73/249 (29%), Positives = 115/249 (46%), Gaps = 19/249 (7%)
Query: 47 AMAATQELLLQLQKDNRDGRQRKQE--------LEKLMRGLEAESESLNQRLQD-LSERE 97
A+ A +EL LQ ++ R RQ + E LE R EAE +S + ++ E
Sbjct: 1671 ALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE 1730
Query: 98 RSLLRRRSQAAQPLQGEAREAARERAERVRRRLEEAERHKEDLEQHSRQ---LQEQWEEL 154
RSL AQ L+ EA A+++AE R R EEAER E + + + L+ Q EE+
Sbjct: 1731 RSLQEEHVAVAQ-LREEAERRAQQQAEAERAR-EEAERELERWQLKANEALRLRLQAEEV 1788
Query: 155 SSQLFYYGGELQSQKSTEQQLAAQLVTLQNELELAETKCALQE-EKLQQDALQTAEAWAI 213
+ Q E + QK E + A+ E + + + A QE EK +Q A TA+
Sbjct: 1789 AQQKSLAQAEAEKQKE-EAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLA 1847
Query: 214 FQEQTVVLQVRPHSDAKEVQVKVMEAAE---ELDAWQSGRELCDGQLRGVQYSTESLMEE 270
+++ + L+ ++ Q+ E A E A R+ + +L V+ E L+
Sbjct: 1848 AEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLAS 1907
Query: 271 MARADRETR 279
ARA+ E+R
Sbjct: 1908 KARAEEESR 1916
Score = 56.2 bits (134), Expect = 4e-08
Identities = 72/261 (27%), Positives = 105/261 (40%), Gaps = 32/261 (12%)
Query: 43 SVSTAMAATQELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQR-LQDLSERERSLL 101
S A A EL L+L GR R + L +AE E+ QR L ER R
Sbjct: 2070 SFEKAAAGKAELELEL------GRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREA 2123
Query: 102 RRRSQAAQPLQGEA---REAARERAERVRRRLEEAERHKEDLEQHS-RQLQEQWEELSSQ 157
R Q + + EA R+AA E ER++ ++EEA R +E EQ S RQLQ E +
Sbjct: 2124 EERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKR 2183
Query: 158 L--------FYYGGELQSQKSTEQQLAAQLVTLQNELELAETKCALQEE-------KLQQ 202
L F + Q + T QQ + L L+ E E A EE + Q
Sbjct: 2184 LQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQ 2243
Query: 203 DALQTAEAWAIFQEQTVVLQVRPHSDA------KEVQVKVMEAAEELDAWQSGRELCDGQ 256
Q EA + Q Q R + A KE + + A+ A ++ D +
Sbjct: 2244 SRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAE 2303
Query: 257 LRGVQYSTESLMEEMARADRE 277
+ + E + + A+ ++E
Sbjct: 2304 MEKHKKFAEQTLRQKAQVEQE 2324
Score = 54.7 bits (130), Expect = 1e-07
Identities = 47/157 (29%), Positives = 77/157 (49%), Gaps = 5/157 (3%)
Query: 52 QELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPL 111
+E L +LQ++ Q++QELE + + AE E L E RS + Q +
Sbjct: 1870 EEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAE 1929
Query: 112 QGEAREAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYYGGELQSQKST 171
G RE A E A R+R EEA+R ++ E+ + + + + E + ++ GE K T
Sbjct: 1930 AGRFRELA-EEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLK-T 1987
Query: 172 EQQLAAQLVTLQNE--LELAETKCALQEEKLQQDALQ 206
E ++A + +NE LAE + A Q +L++ A Q
Sbjct: 1988 EAEIALKEKEAENERLRRLAEDE-AFQRRRLEEQAAQ 2023
Score = 52.4 bits (124), Expect = 6e-07
Identities = 64/274 (23%), Positives = 114/274 (41%), Gaps = 52/274 (18%)
Query: 47 AMAATQELLLQLQKDNRDGRQRKQELEKLMRGLE------AESESLNQRLQDLSERERSL 100
A +E +Q +++ R++ +E E+L + E A++++ ++L+ +E+E +
Sbjct: 2226 AAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAA- 2284
Query: 101 LRRRSQAAQPLQGEAREAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFY 160
RR+QA Q + ++AA E+ ++ E+ R K +EQ L+ Q EE Q
Sbjct: 2285 --RRAQAEQAALRQ-KQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL 2341
Query: 161 YGGELQSQKSTEQQLAAQLVTLQNEL--------ELAETKCAL----------------- 195
ELQ K+ + A Q ++ EL EL++ K +
Sbjct: 2342 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2401
Query: 196 ----QEEKLQQDALQTAEAWAIFQEQTVVLQVRPHSDA----------KEVQVKVMEAAE 241
+ EK++Q A + A QE + Q+ A KE V EA
Sbjct: 2402 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2461
Query: 242 ---ELDAWQSGRELCDGQLRGVQYSTESLMEEMA 272
E + Q +EL Q R +Q E + +++A
Sbjct: 2462 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLA 2495
Score = 50.8 bits (120), Expect = 2e-06
Identities = 61/250 (24%), Positives = 112/250 (44%), Gaps = 35/250 (14%)
Query: 52 QELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPL 111
Q L + ++ RQ ++E E+L R ++ ES+ Q +L+ R ++ + + L
Sbjct: 1613 QALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRAL 1672
Query: 112 QGEAREAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYYGGELQSQKST 171
Q A E R +AE RRL +AE + +RQ+Q E ELQS++++
Sbjct: 1673 Q--ALEELRLQAEEAERRLRQAE------VERARQVQVALETAQRSA---EAELQSKRAS 1721
Query: 172 EQQLAAQLV-TLQNE-------LELAETKCALQ--EEKLQQDALQTAEAWAIFQEQTVVL 221
+ AQL +LQ E E AE + Q E+ +++A + E W + + + L
Sbjct: 1722 FAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRL 1781
Query: 222 QVRPHSDAKEVQVKVMEAAE-----ELDAWQSG---------RELCDGQLRGVQYSTESL 267
+++ A++ + EA + E +A + G REL + +L + E
Sbjct: 1782 RLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGT 1841
Query: 268 MEEMARADRE 277
++ A++E
Sbjct: 1842 AQQRLAAEQE 1851
Score = 48.9 bits (115), Expect = 7e-06
Identities = 63/267 (23%), Positives = 114/267 (42%), Gaps = 57/267 (21%)
Query: 57 QLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSER----ERSLLRRRSQAAQPLQ 112
Q++++ R + +EL KL +EAE+ +L R +D ++R E +++ ++ A L
Sbjct: 2362 QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLS 2421
Query: 113 GEAREAARER---------------------------AERVRRRLEEAERHKEDLEQHSR 145
A+EAAR R A R++ E ++ KE ++ +R
Sbjct: 2422 VAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR 2481
Query: 146 QLQEQWEELSSQL------FYYGGELQSQKSTEQQLAAQLVTLQNELELAETKCALQE-- 197
+LQE E+++ QL F E + Q+ E A+ + L+ E++ + +E
Sbjct: 2482 RLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLR-VAEMSRAQARAEEDA 2540
Query: 198 -----------EKLQQDALQTAEAWAIFQEQTVVLQVRPHSDAKEVQVKVMEAAEELDAW 246
EKL + L T E + Q + Q H DA+ ++ + E E +
Sbjct: 2541 QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH-DAERLREAIAELEREKEKL 2599
Query: 247 QSGRELCDGQLRGVQYST---ESLMEE 270
Q +L QL+ + T E L++E
Sbjct: 2600 QQEAKLL--QLKSEEMQTVQQEQLLQE 2624
Score = 47.8 bits (112), Expect = 2e-05
Identities = 62/265 (23%), Positives = 107/265 (40%), Gaps = 30/265 (11%)
Query: 19 RRSLPPIVTPASRRLGPRGGRHL----GSVSTAMAATQELLLQLQKDNRDGRQRKQELEK 74
+ L P+ +PA + G + + T + L Q K + +R +E E+
Sbjct: 1427 KAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER 1486
Query: 75 LMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPLQGEAREAARERAERVRRRLEEAE 134
L AE ++ E++R L +QA + EA+E + E V RR E A
Sbjct: 1487 LAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA- 1545
Query: 135 RHKEDLEQHSRQLQEQWEELSSQLFYYGGELQSQKSTEQQLAAQLVTLQNELELAETKCA 194
D +Q R +QE+ ++L E + Q Q AA+ L+ E E+ +
Sbjct: 1546 ---VDAQQQKRSIQEELQQLRQ-----SSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ 1597
Query: 195 LQEEKLQQDALQTAEAWAIFQEQTVVLQVRPHSDAKEVQVKVMEAAEELDAWQSGRELCD 254
L+ + Q+ + E A+ + A+E + + +A EE + + R++ D
Sbjct: 1598 LEATERQRGGAE-GELQAL------------RARAEEAEAQKRQAQEEAERLR--RQVQD 1642
Query: 255 GQLRGVQYSTE--SLMEEMARADRE 277
R Q E S ++ A A RE
Sbjct: 1643 ESQRKRQAEVELASRVKAEAEAARE 1667
Score = 45.1 bits (105), Expect = 1e-04
Identities = 69/283 (24%), Positives = 110/283 (38%), Gaps = 64/283 (22%)
Query: 45 STAMAATQELLLQLQKD---------NRDGRQRKQELEKLMRGLEAESESLNQRLQDLS- 94
+T + A E LLQ QK+ D Q Q+L + +G + E+ QR ++S
Sbjct: 2459 ATRLKAEAE-LLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSA 2517
Query: 95 ERERSLLR---------RRSQAAQPLQGEARE----------AARER------------- 122
E ER LR R + AQ + +A E A +E+
Sbjct: 2518 EAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQ 2577
Query: 123 ----AERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYYGGELQSQKSTEQQLAAQ 178
AER+R + E ER KE L+Q ++ LQ + EE+ Q ++QL +
Sbjct: 2578 SDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM-------------QTVQQEQLLQE 2624
Query: 179 LVTLQNELELAETKCALQEEKLQQDALQTAEAWAIFQEQTVVLQVRPHSDAKEVQVKVME 238
LQ L+E LQ E+ + + A+ +FQ++ Q ++ Q E
Sbjct: 2625 TQALQQSF-LSEKDSLLQRERFIEQ--EKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQE 2681
Query: 239 AAEELDAWQSGRELCDGQLRGVQYSTESLME-EMARADRETRL 280
+ + + R GV+ E L + E R +E L
Sbjct: 2682 RQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELL 2724
Score = 43.5 bits (101), Expect = 3e-04
Identities = 70/286 (24%), Positives = 121/286 (42%), Gaps = 53/286 (18%)
Query: 32 RLGPRGGRHLGSVSTAMAATQELLLQLQKDNRDGRQRKQELEKLMRGLEAESES---LNQ 88
RL R G V +LL + Q R++ELE+L R L ES L
Sbjct: 1299 RLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGA 1358
Query: 89 RLQDLSERERSLLRRRSQAAQPLQGEAREAARERAERVRRRLEEAERHKEDLEQ---HSR 145
LQD RRR + Q + +A RE+ + + LEE ERH E +E+ ++
Sbjct: 1359 WLQDA--------RRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAK 1410
Query: 146 QLQEQWEELSSQLFYYGGELQS----------QKSTEQQLA---------AQLVTLQNE- 185
Q ++ QL Y +L+ Q +E + ++L TL ++
Sbjct: 1411 QYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQY 1470
Query: 186 -------LELAETKCALQEEKLQQDALQTAEAWAIFQEQTVVLQVRPHS------DAKEV 232
L E + L E++ ++ + AE A ++Q + + + +AKE+
Sbjct: 1471 IKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKEL 1530
Query: 233 QVKVMEAA---EE--LDAWQSGRELCDGQLRGVQYSTESLMEEMAR 273
Q ++ E EE +DA Q R + + +L+ ++ S+E+ ++ AR
Sbjct: 1531 QQRMQEEVVRREEAAVDAQQQKRSIQE-ELQQLRQSSEAEIQAKAR 1575
Score = 42.0 bits (97), Expect = 8e-04
Identities = 65/240 (27%), Positives = 105/240 (43%), Gaps = 53/240 (22%)
Query: 53 ELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQ------RLQDLSE---RERSLL-- 101
E+ + L R + + EK + LEAE+ + RL+ L+E R+R L
Sbjct: 1900 EMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE 1959
Query: 102 ---RRRSQAAQPLQ------GEA-------------REAARERAERV-------RRRLEE 132
R+R++A + L GEA +EA ER R+ RRRLEE
Sbjct: 1960 DAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEE 2019
Query: 133 -AERHKEDLEQHSRQLQEQWE-ELSSQLFYYGGELQSQKSTEQQLAAQLVTLQN------ 184
A +HK D+E+ QL++ + EL Q L+ ++ E+++ A + +
Sbjct: 2020 QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 2079
Query: 185 --ELELAETKCALQEEKLQQDALQTAEAWAIFQEQTVVLQVRPHSDAKEVQVKVMEAAEE 242
ELEL + + E+ L+ + + AE A Q Q + R +A+E K + A EE
Sbjct: 2080 ELELELGRIR-SNAEDTLR--SKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 2136
Score = 41.6 bits (96), Expect = 0.001
Identities = 40/159 (25%), Positives = 71/159 (44%), Gaps = 10/159 (6%)
Query: 67 QRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPLQGEAREAARERAERV 126
Q K +LE+L + A++ Q+L++ +R++ + + Q EAR E E V
Sbjct: 2648 QEKAKLEQLFQDEVAKA----QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV 2703
Query: 127 RRRLEEAERHKEDLEQHSRQLQEQWEELSSQL-----FYYGGELQSQKSTEQQLAAQLVT 181
RR+ EE ++ ++ Q L E+ + L QL + S++ T Q+AA T
Sbjct: 2704 RRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAA-TKT 2762
Query: 182 LQNELELAETKCALQEEKLQQDALQTAEAWAIFQEQTVV 220
L N + + A E + D L+ + QE ++
Sbjct: 2763 LPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGIL 2801
Score = 41.2 bits (95), Expect = 0.001
Identities = 33/139 (23%), Positives = 62/139 (44%), Gaps = 18/139 (12%)
Query: 52 QELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPL 111
++LL + Q + K L + R +E E L Q QD + + L + + Q +
Sbjct: 2619 EQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQM 2678
Query: 112 QGEAREAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYYGGELQSQKST 171
+ E +R+ +EEA R + + E+ R+ QE+ ++L Q ++
Sbjct: 2679 EQE--------RQRLVASMEEARRRQHEAEEGVRRKQEELQQLE----------QQRRQQ 2720
Query: 172 EQQLAAQLVTLQNELELAE 190
E+ LA + L+ +L+L E
Sbjct: 2721 EELLAEENQRLREQLQLLE 2739
Score = 38.1 bits (87), Expect = 0.012
Identities = 44/165 (26%), Positives = 77/165 (46%), Gaps = 38/165 (23%)
Query: 70 QELEKLMRGLEA---ESESLNQRLQDLSERERSL--LRRRSQAAQPLQGEARE---AARE 121
Q E+++R E E++++ L +L + SL LR +++A QP R+ A+E
Sbjct: 1236 QGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQE 1295
Query: 122 RAERVRRRLEEAERHKEDLEQHSRQLQEQW--------------EELSSQLFYY------ 161
ER+++R E + E + QL E+W E+L QL YY
Sbjct: 1296 VGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADP 1355
Query: 162 -GGELQSQKSTEQQLAAQLVTLQNELELAETKCALQEEKLQQDAL 205
G LQ + ++Q+ A + LA+++ A++E+ Q+ AL
Sbjct: 1356 LGAWLQDARRRQEQIQA--------MPLADSQ-AVREQLRQEQAL 1391
Score = 32.3 bits (72), Expect = 0.67
Identities = 27/110 (24%), Positives = 53/110 (48%), Gaps = 13/110 (11%)
Query: 52 QELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPL 111
Q+ + + Q+ + ++++Q++E+ + L A E +R + E +RR+ + Q L
Sbjct: 2658 QDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEG----VRRKQEELQQL 2713
Query: 112 QGEAR---EAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQL 158
+ + R E E +R+R +L+ E EQH L E +SQ+
Sbjct: 2714 EQQRRQQEELLAEENQRLREQLQLLE------EQHRAALAHSEEVTASQV 2757
Score = 32.0 bits (71), Expect = 0.87
Identities = 45/212 (21%), Positives = 91/212 (42%), Gaps = 34/212 (16%)
Query: 70 QELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPLQGEAREAARERAERVRRR 129
Q LE + + ++E L + + +L ERE+ L++ ++ Q E + +E+ + +
Sbjct: 2569 QTLEIQRQQSDHDAERLREAIAEL-EREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA 2627
Query: 130 LEEAERHKED--------LEQHSRQLQEQWEELSSQLFYYGGELQSQKSTEQQLAAQLVT 181
L+++ ++D +EQ +L++ +++ ++ E Q Q+ +Q +LV
Sbjct: 2628 LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVA 2687
Query: 182 ------------------LQNELELAETKCALQEEKLQQDALQTAEAWAIFQEQTVVLQV 223
Q EL+ E + QEE L ++ + E + +EQ
Sbjct: 2688 SMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQH--RAA 2745
Query: 224 RPHSDAKEVQVKVMEAAEELDAWQSGRELCDG 255
HS+ EV + A + L +GR+ DG
Sbjct: 2746 LAHSE--EVTASQVAATKTL---PNGRDALDG 2772
Score = 30.0 bits (66), Expect = 3.3
Identities = 63/282 (22%), Positives = 105/282 (37%), Gaps = 73/282 (25%)
Query: 52 QELLLQLQKDNRD-GRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLR-------- 102
QE +LQ+D +Q +E + R LEAE + ++L+ +E ER LR
Sbjct: 2477 QEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ---RQLEMSAEAERLKLRVAEMSRAQ 2533
Query: 103 -RRSQAAQPLQGEARE----------AARER-----------------AERVRRRLEEAE 134
R + AQ + +A E A +E+ AER+R + E E
Sbjct: 2534 ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE 2593
Query: 135 RHKEDLEQH----------------------SRQLQEQWEELSSQLFYYGGELQSQKSTE 172
R KE L+Q ++ LQ+ + L LQ ++ E
Sbjct: 2594 REKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL------LQRERFIE 2647
Query: 173 QQLAAQLVTLQNELELAETKCALQEEKLQQDALQTAEAWAIFQEQTVVLQVRPHSDAKEV 232
Q+ A Q+E+ A+ Q+ + QQ + A +E R +A+E
Sbjct: 2648 QEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR-----RRQHEAEEG 2702
Query: 233 QVKVMEAAEELDAWQSGRELCDGQLRGVQYSTESLMEEMARA 274
+ E ++L+ + +E + L+EE RA
Sbjct: 2703 VRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRA 2744
Score = 28.9 bits (63), Expect = 7.4
Identities = 31/113 (27%), Positives = 48/113 (42%), Gaps = 22/113 (19%)
Query: 48 MAATQELLLQLQKDNRDGRQRKQE----LEKLMRGLEA----ESESLNQRLQDLSERERS 99
+ A+ E + Q + +G +RKQE LE+ R E E++ L ++LQ L E+ R+
Sbjct: 2685 LVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRA 2744
Query: 100 LLRRRSQAA--------------QPLQGEAREAARERAERVRRRLEEAERHKE 138
L + L G A EA E + RR A+R +E
Sbjct: 2745 ALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQE 2797
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 61.6 bits (148), Expect = 1e-09
Identities = 73/249 (29%), Positives = 115/249 (46%), Gaps = 19/249 (7%)
Query: 47 AMAATQELLLQLQKDNRDGRQRKQE--------LEKLMRGLEAESESLNQRLQD-LSERE 97
A+ A +EL LQ ++ R RQ + E LE R EAE +S + ++ E
Sbjct: 1512 ALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE 1571
Query: 98 RSLLRRRSQAAQPLQGEAREAARERAERVRRRLEEAERHKEDLEQHSRQ---LQEQWEEL 154
RSL AQ L+ EA A+++AE R R EEAER E + + + L+ Q EE+
Sbjct: 1572 RSLQEEHVAVAQ-LREEAERRAQQQAEAERAR-EEAERELERWQLKANEALRLRLQAEEV 1629
Query: 155 SSQLFYYGGELQSQKSTEQQLAAQLVTLQNELELAETKCALQE-EKLQQDALQTAEAWAI 213
+ Q E + QK E + A+ E + + + A QE EK +Q A TA+
Sbjct: 1630 AQQKSLAQAEAEKQKE-EAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLA 1688
Query: 214 FQEQTVVLQVRPHSDAKEVQVKVMEAAE---ELDAWQSGRELCDGQLRGVQYSTESLMEE 270
+++ + L+ ++ Q+ E A E A R+ + +L V+ E L+
Sbjct: 1689 AEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLAS 1748
Query: 271 MARADRETR 279
ARA+ E+R
Sbjct: 1749 KARAEEESR 1757
Score = 56.2 bits (134), Expect = 4e-08
Identities = 72/261 (27%), Positives = 105/261 (40%), Gaps = 32/261 (12%)
Query: 43 SVSTAMAATQELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQR-LQDLSERERSLL 101
S A A EL L+L GR R + L +AE E+ QR L ER R
Sbjct: 1911 SFEKAAAGKAELELEL------GRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREA 1964
Query: 102 RRRSQAAQPLQGEA---REAARERAERVRRRLEEAERHKEDLEQHS-RQLQEQWEELSSQ 157
R Q + + EA R+AA E ER++ ++EEA R +E EQ S RQLQ E +
Sbjct: 1965 EERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKR 2024
Query: 158 L--------FYYGGELQSQKSTEQQLAAQLVTLQNELELAETKCALQEE-------KLQQ 202
L F + Q + T QQ + L L+ E E A EE + Q
Sbjct: 2025 LQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQ 2084
Query: 203 DALQTAEAWAIFQEQTVVLQVRPHSDA------KEVQVKVMEAAEELDAWQSGRELCDGQ 256
Q EA + Q Q R + A KE + + A+ A ++ D +
Sbjct: 2085 SRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAE 2144
Query: 257 LRGVQYSTESLMEEMARADRE 277
+ + E + + A+ ++E
Sbjct: 2145 MEKHKKFAEQTLRQKAQVEQE 2165
Score = 54.7 bits (130), Expect = 1e-07
Identities = 47/157 (29%), Positives = 77/157 (49%), Gaps = 5/157 (3%)
Query: 52 QELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPL 111
+E L +LQ++ Q++QELE + + AE E L E RS + Q +
Sbjct: 1711 EEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAE 1770
Query: 112 QGEAREAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYYGGELQSQKST 171
G RE A E A R+R EEA+R ++ E+ + + + + E + ++ GE K T
Sbjct: 1771 AGRFRELA-EEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLK-T 1828
Query: 172 EQQLAAQLVTLQNE--LELAETKCALQEEKLQQDALQ 206
E ++A + +NE LAE + A Q +L++ A Q
Sbjct: 1829 EAEIALKEKEAENERLRRLAEDE-AFQRRRLEEQAAQ 1864
Score = 52.4 bits (124), Expect = 6e-07
Identities = 64/274 (23%), Positives = 114/274 (41%), Gaps = 52/274 (18%)
Query: 47 AMAATQELLLQLQKDNRDGRQRKQELEKLMRGLE------AESESLNQRLQDLSERERSL 100
A +E +Q +++ R++ +E E+L + E A++++ ++L+ +E+E +
Sbjct: 2067 AAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAA- 2125
Query: 101 LRRRSQAAQPLQGEAREAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFY 160
RR+QA Q + ++AA E+ ++ E+ R K +EQ L+ Q EE Q
Sbjct: 2126 --RRAQAEQAALRQ-KQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL 2182
Query: 161 YGGELQSQKSTEQQLAAQLVTLQNEL--------ELAETKCAL----------------- 195
ELQ K+ + A Q ++ EL EL++ K +
Sbjct: 2183 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2242
Query: 196 ----QEEKLQQDALQTAEAWAIFQEQTVVLQVRPHSDA----------KEVQVKVMEAAE 241
+ EK++Q A + A QE + Q+ A KE V EA
Sbjct: 2243 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2302
Query: 242 ---ELDAWQSGRELCDGQLRGVQYSTESLMEEMA 272
E + Q +EL Q R +Q E + +++A
Sbjct: 2303 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLA 2336
Score = 50.8 bits (120), Expect = 2e-06
Identities = 61/250 (24%), Positives = 112/250 (44%), Gaps = 35/250 (14%)
Query: 52 QELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPL 111
Q L + ++ RQ ++E E+L R ++ ES+ Q +L+ R ++ + + L
Sbjct: 1454 QALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRAL 1513
Query: 112 QGEAREAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYYGGELQSQKST 171
Q A E R +AE RRL +AE + +RQ+Q E ELQS++++
Sbjct: 1514 Q--ALEELRLQAEEAERRLRQAE------VERARQVQVALETAQRSA---EAELQSKRAS 1562
Query: 172 EQQLAAQLV-TLQNE-------LELAETKCALQ--EEKLQQDALQTAEAWAIFQEQTVVL 221
+ AQL +LQ E E AE + Q E+ +++A + E W + + + L
Sbjct: 1563 FAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRL 1622
Query: 222 QVRPHSDAKEVQVKVMEAAE-----ELDAWQSG---------RELCDGQLRGVQYSTESL 267
+++ A++ + EA + E +A + G REL + +L + E
Sbjct: 1623 RLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGT 1682
Query: 268 MEEMARADRE 277
++ A++E
Sbjct: 1683 AQQRLAAEQE 1692
Score = 48.9 bits (115), Expect = 7e-06
Identities = 63/267 (23%), Positives = 114/267 (42%), Gaps = 57/267 (21%)
Query: 57 QLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSER----ERSLLRRRSQAAQPLQ 112
Q++++ R + +EL KL +EAE+ +L R +D ++R E +++ ++ A L
Sbjct: 2203 QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLS 2262
Query: 113 GEAREAARER---------------------------AERVRRRLEEAERHKEDLEQHSR 145
A+EAAR R A R++ E ++ KE ++ +R
Sbjct: 2263 VAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR 2322
Query: 146 QLQEQWEELSSQL------FYYGGELQSQKSTEQQLAAQLVTLQNELELAETKCALQE-- 197
+LQE E+++ QL F E + Q+ E A+ + L+ E++ + +E
Sbjct: 2323 RLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLR-VAEMSRAQARAEEDA 2381
Query: 198 -----------EKLQQDALQTAEAWAIFQEQTVVLQVRPHSDAKEVQVKVMEAAEELDAW 246
EKL + L T E + Q + Q H DA+ ++ + E E +
Sbjct: 2382 QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH-DAERLREAIAELEREKEKL 2440
Query: 247 QSGRELCDGQLRGVQYST---ESLMEE 270
Q +L QL+ + T E L++E
Sbjct: 2441 QQEAKLL--QLKSEEMQTVQQEQLLQE 2465
Score = 47.8 bits (112), Expect = 2e-05
Identities = 62/265 (23%), Positives = 107/265 (40%), Gaps = 30/265 (11%)
Query: 19 RRSLPPIVTPASRRLGPRGGRHL----GSVSTAMAATQELLLQLQKDNRDGRQRKQELEK 74
+ L P+ +PA + G + + T + L Q K + +R +E E+
Sbjct: 1268 KAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER 1327
Query: 75 LMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPLQGEAREAARERAERVRRRLEEAE 134
L AE ++ E++R L +QA + EA+E + E V RR E A
Sbjct: 1328 LAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA- 1386
Query: 135 RHKEDLEQHSRQLQEQWEELSSQLFYYGGELQSQKSTEQQLAAQLVTLQNELELAETKCA 194
D +Q R +QE+ ++L E + Q Q AA+ L+ E E+ +
Sbjct: 1387 ---VDAQQQKRSIQEELQQLRQ-----SSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ 1438
Query: 195 LQEEKLQQDALQTAEAWAIFQEQTVVLQVRPHSDAKEVQVKVMEAAEELDAWQSGRELCD 254
L+ + Q+ + E A+ + A+E + + +A EE + + R++ D
Sbjct: 1439 LEATERQRGGAE-GELQAL------------RARAEEAEAQKRQAQEEAERLR--RQVQD 1483
Query: 255 GQLRGVQYSTE--SLMEEMARADRE 277
R Q E S ++ A A RE
Sbjct: 1484 ESQRKRQAEVELASRVKAEAEAARE 1508
Score = 45.1 bits (105), Expect = 1e-04
Identities = 69/283 (24%), Positives = 110/283 (38%), Gaps = 64/283 (22%)
Query: 45 STAMAATQELLLQLQKD---------NRDGRQRKQELEKLMRGLEAESESLNQRLQDLS- 94
+T + A E LLQ QK+ D Q Q+L + +G + E+ QR ++S
Sbjct: 2300 ATRLKAEAE-LLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSA 2358
Query: 95 ERERSLLR---------RRSQAAQPLQGEARE----------AARER------------- 122
E ER LR R + AQ + +A E A +E+
Sbjct: 2359 EAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQ 2418
Query: 123 ----AERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYYGGELQSQKSTEQQLAAQ 178
AER+R + E ER KE L+Q ++ LQ + EE+ Q ++QL +
Sbjct: 2419 SDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM-------------QTVQQEQLLQE 2465
Query: 179 LVTLQNELELAETKCALQEEKLQQDALQTAEAWAIFQEQTVVLQVRPHSDAKEVQVKVME 238
LQ L+E LQ E+ + + A+ +FQ++ Q ++ Q E
Sbjct: 2466 TQALQQSF-LSEKDSLLQRERFIEQ--EKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQE 2522
Query: 239 AAEELDAWQSGRELCDGQLRGVQYSTESLME-EMARADRETRL 280
+ + + R GV+ E L + E R +E L
Sbjct: 2523 RQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELL 2565
Score = 43.5 bits (101), Expect = 3e-04
Identities = 70/286 (24%), Positives = 121/286 (42%), Gaps = 53/286 (18%)
Query: 32 RLGPRGGRHLGSVSTAMAATQELLLQLQKDNRDGRQRKQELEKLMRGLEAESES---LNQ 88
RL R G V +LL + Q R++ELE+L R L ES L
Sbjct: 1140 RLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGA 1199
Query: 89 RLQDLSERERSLLRRRSQAAQPLQGEAREAARERAERVRRRLEEAERHKEDLEQ---HSR 145
LQD RRR + Q + +A RE+ + + LEE ERH E +E+ ++
Sbjct: 1200 WLQDA--------RRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAK 1251
Query: 146 QLQEQWEELSSQLFYYGGELQS----------QKSTEQQLA---------AQLVTLQNE- 185
Q ++ QL Y +L+ Q +E + ++L TL ++
Sbjct: 1252 QYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQY 1311
Query: 186 -------LELAETKCALQEEKLQQDALQTAEAWAIFQEQTVVLQVRPHS------DAKEV 232
L E + L E++ ++ + AE A ++Q + + + +AKE+
Sbjct: 1312 IKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKEL 1371
Query: 233 QVKVMEAA---EE--LDAWQSGRELCDGQLRGVQYSTESLMEEMAR 273
Q ++ E EE +DA Q R + + +L+ ++ S+E+ ++ AR
Sbjct: 1372 QQRMQEEVVRREEAAVDAQQQKRSIQE-ELQQLRQSSEAEIQAKAR 1416
Score = 42.0 bits (97), Expect = 8e-04
Identities = 65/240 (27%), Positives = 105/240 (43%), Gaps = 53/240 (22%)
Query: 53 ELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQ------RLQDLSE---RERSLL-- 101
E+ + L R + + EK + LEAE+ + RL+ L+E R+R L
Sbjct: 1741 EMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE 1800
Query: 102 ---RRRSQAAQPLQ------GEA-------------REAARERAERV-------RRRLEE 132
R+R++A + L GEA +EA ER R+ RRRLEE
Sbjct: 1801 DAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEE 1860
Query: 133 -AERHKEDLEQHSRQLQEQWE-ELSSQLFYYGGELQSQKSTEQQLAAQLVTLQN------ 184
A +HK D+E+ QL++ + EL Q L+ ++ E+++ A + +
Sbjct: 1861 QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 1920
Query: 185 --ELELAETKCALQEEKLQQDALQTAEAWAIFQEQTVVLQVRPHSDAKEVQVKVMEAAEE 242
ELEL + + E+ L+ + + AE A Q Q + R +A+E K + A EE
Sbjct: 1921 ELELELGRIR-SNAEDTLR--SKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 1977
Score = 41.6 bits (96), Expect = 0.001
Identities = 40/159 (25%), Positives = 71/159 (44%), Gaps = 10/159 (6%)
Query: 67 QRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPLQGEAREAARERAERV 126
Q K +LE+L + A++ Q+L++ +R++ + + Q EAR E E V
Sbjct: 2489 QEKAKLEQLFQDEVAKA----QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV 2544
Query: 127 RRRLEEAERHKEDLEQHSRQLQEQWEELSSQL-----FYYGGELQSQKSTEQQLAAQLVT 181
RR+ EE ++ ++ Q L E+ + L QL + S++ T Q+AA T
Sbjct: 2545 RRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAA-TKT 2603
Query: 182 LQNELELAETKCALQEEKLQQDALQTAEAWAIFQEQTVV 220
L N + + A E + D L+ + QE ++
Sbjct: 2604 LPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGIL 2642
Score = 41.2 bits (95), Expect = 0.001
Identities = 33/139 (23%), Positives = 62/139 (44%), Gaps = 18/139 (12%)
Query: 52 QELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPL 111
++LL + Q + K L + R +E E L Q QD + + L + + Q +
Sbjct: 2460 EQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQM 2519
Query: 112 QGEAREAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYYGGELQSQKST 171
+ E +R+ +EEA R + + E+ R+ QE+ ++L Q ++
Sbjct: 2520 EQE--------RQRLVASMEEARRRQHEAEEGVRRKQEELQQLE----------QQRRQQ 2561
Query: 172 EQQLAAQLVTLQNELELAE 190
E+ LA + L+ +L+L E
Sbjct: 2562 EELLAEENQRLREQLQLLE 2580
Score = 38.1 bits (87), Expect = 0.012
Identities = 44/165 (26%), Positives = 77/165 (46%), Gaps = 38/165 (23%)
Query: 70 QELEKLMRGLEA---ESESLNQRLQDLSERERSL--LRRRSQAAQPLQGEARE---AARE 121
Q E+++R E E++++ L +L + SL LR +++A QP R+ A+E
Sbjct: 1077 QGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQE 1136
Query: 122 RAERVRRRLEEAERHKEDLEQHSRQLQEQW--------------EELSSQLFYY------ 161
ER+++R E + E + QL E+W E+L QL YY
Sbjct: 1137 VGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADP 1196
Query: 162 -GGELQSQKSTEQQLAAQLVTLQNELELAETKCALQEEKLQQDAL 205
G LQ + ++Q+ A + LA+++ A++E+ Q+ AL
Sbjct: 1197 LGAWLQDARRRQEQIQA--------MPLADSQ-AVREQLRQEQAL 1232
Score = 32.3 bits (72), Expect = 0.67
Identities = 27/110 (24%), Positives = 53/110 (48%), Gaps = 13/110 (11%)
Query: 52 QELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPL 111
Q+ + + Q+ + ++++Q++E+ + L A E +R + E +RR+ + Q L
Sbjct: 2499 QDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEG----VRRKQEELQQL 2554
Query: 112 QGEAR---EAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQL 158
+ + R E E +R+R +L+ E EQH L E +SQ+
Sbjct: 2555 EQQRRQQEELLAEENQRLREQLQLLE------EQHRAALAHSEEVTASQV 2598
Score = 32.0 bits (71), Expect = 0.87
Identities = 45/212 (21%), Positives = 91/212 (42%), Gaps = 34/212 (16%)
Query: 70 QELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPLQGEAREAARERAERVRRR 129
Q LE + + ++E L + + +L ERE+ L++ ++ Q E + +E+ + +
Sbjct: 2410 QTLEIQRQQSDHDAERLREAIAEL-EREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA 2468
Query: 130 LEEAERHKED--------LEQHSRQLQEQWEELSSQLFYYGGELQSQKSTEQQLAAQLVT 181
L+++ ++D +EQ +L++ +++ ++ E Q Q+ +Q +LV
Sbjct: 2469 LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVA 2528
Query: 182 ------------------LQNELELAETKCALQEEKLQQDALQTAEAWAIFQEQTVVLQV 223
Q EL+ E + QEE L ++ + E + +EQ
Sbjct: 2529 SMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQH--RAA 2586
Query: 224 RPHSDAKEVQVKVMEAAEELDAWQSGRELCDG 255
HS+ EV + A + L +GR+ DG
Sbjct: 2587 LAHSE--EVTASQVAATKTL---PNGRDALDG 2613
Score = 30.0 bits (66), Expect = 3.3
Identities = 63/282 (22%), Positives = 105/282 (37%), Gaps = 73/282 (25%)
Query: 52 QELLLQLQKDNRD-GRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLR-------- 102
QE +LQ+D +Q +E + R LEAE + ++L+ +E ER LR
Sbjct: 2318 QEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ---RQLEMSAEAERLKLRVAEMSRAQ 2374
Query: 103 -RRSQAAQPLQGEARE----------AARER-----------------AERVRRRLEEAE 134
R + AQ + +A E A +E+ AER+R + E E
Sbjct: 2375 ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE 2434
Query: 135 RHKEDLEQH----------------------SRQLQEQWEELSSQLFYYGGELQSQKSTE 172
R KE L+Q ++ LQ+ + L LQ ++ E
Sbjct: 2435 REKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL------LQRERFIE 2488
Query: 173 QQLAAQLVTLQNELELAETKCALQEEKLQQDALQTAEAWAIFQEQTVVLQVRPHSDAKEV 232
Q+ A Q+E+ A+ Q+ + QQ + A +E R +A+E
Sbjct: 2489 QEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR-----RRQHEAEEG 2543
Query: 233 QVKVMEAAEELDAWQSGRELCDGQLRGVQYSTESLMEEMARA 274
+ E ++L+ + +E + L+EE RA
Sbjct: 2544 VRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRA 2585
Score = 28.9 bits (63), Expect = 7.4
Identities = 31/113 (27%), Positives = 48/113 (42%), Gaps = 22/113 (19%)
Query: 48 MAATQELLLQLQKDNRDGRQRKQE----LEKLMRGLEA----ESESLNQRLQDLSERERS 99
+ A+ E + Q + +G +RKQE LE+ R E E++ L ++LQ L E+ R+
Sbjct: 2526 LVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRA 2585
Query: 100 LLRRRSQAA--------------QPLQGEAREAARERAERVRRRLEEAERHKE 138
L + L G A EA E + RR A+R +E
Sbjct: 2586 ALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQE 2638
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 61.6 bits (148), Expect = 1e-09
Identities = 73/249 (29%), Positives = 115/249 (46%), Gaps = 19/249 (7%)
Query: 47 AMAATQELLLQLQKDNRDGRQRKQE--------LEKLMRGLEAESESLNQRLQD-LSERE 97
A+ A +EL LQ ++ R RQ + E LE R EAE +S + ++ E
Sbjct: 1520 ALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE 1579
Query: 98 RSLLRRRSQAAQPLQGEAREAARERAERVRRRLEEAERHKEDLEQHSRQ---LQEQWEEL 154
RSL AQ L+ EA A+++AE R R EEAER E + + + L+ Q EE+
Sbjct: 1580 RSLQEEHVAVAQ-LREEAERRAQQQAEAERAR-EEAERELERWQLKANEALRLRLQAEEV 1637
Query: 155 SSQLFYYGGELQSQKSTEQQLAAQLVTLQNELELAETKCALQE-EKLQQDALQTAEAWAI 213
+ Q E + QK E + A+ E + + + A QE EK +Q A TA+
Sbjct: 1638 AQQKSLAQAEAEKQKE-EAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLA 1696
Query: 214 FQEQTVVLQVRPHSDAKEVQVKVMEAAE---ELDAWQSGRELCDGQLRGVQYSTESLMEE 270
+++ + L+ ++ Q+ E A E A R+ + +L V+ E L+
Sbjct: 1697 AEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLAS 1756
Query: 271 MARADRETR 279
ARA+ E+R
Sbjct: 1757 KARAEEESR 1765
Score = 56.2 bits (134), Expect = 4e-08
Identities = 72/261 (27%), Positives = 105/261 (40%), Gaps = 32/261 (12%)
Query: 43 SVSTAMAATQELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQR-LQDLSERERSLL 101
S A A EL L+L GR R + L +AE E+ QR L ER R
Sbjct: 1919 SFEKAAAGKAELELEL------GRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREA 1972
Query: 102 RRRSQAAQPLQGEA---REAARERAERVRRRLEEAERHKEDLEQHS-RQLQEQWEELSSQ 157
R Q + + EA R+AA E ER++ ++EEA R +E EQ S RQLQ E +
Sbjct: 1973 EERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKR 2032
Query: 158 L--------FYYGGELQSQKSTEQQLAAQLVTLQNELELAETKCALQEE-------KLQQ 202
L F + Q + T QQ + L L+ E E A EE + Q
Sbjct: 2033 LQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQ 2092
Query: 203 DALQTAEAWAIFQEQTVVLQVRPHSDA------KEVQVKVMEAAEELDAWQSGRELCDGQ 256
Q EA + Q Q R + A KE + + A+ A ++ D +
Sbjct: 2093 SRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAE 2152
Query: 257 LRGVQYSTESLMEEMARADRE 277
+ + E + + A+ ++E
Sbjct: 2153 MEKHKKFAEQTLRQKAQVEQE 2173
Score = 54.7 bits (130), Expect = 1e-07
Identities = 47/157 (29%), Positives = 77/157 (49%), Gaps = 5/157 (3%)
Query: 52 QELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPL 111
+E L +LQ++ Q++QELE + + AE E L E RS + Q +
Sbjct: 1719 EEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAE 1778
Query: 112 QGEAREAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYYGGELQSQKST 171
G RE A E A R+R EEA+R ++ E+ + + + + E + ++ GE K T
Sbjct: 1779 AGRFRELA-EEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLK-T 1836
Query: 172 EQQLAAQLVTLQNE--LELAETKCALQEEKLQQDALQ 206
E ++A + +NE LAE + A Q +L++ A Q
Sbjct: 1837 EAEIALKEKEAENERLRRLAEDE-AFQRRRLEEQAAQ 1872
Score = 52.4 bits (124), Expect = 6e-07
Identities = 64/274 (23%), Positives = 114/274 (41%), Gaps = 52/274 (18%)
Query: 47 AMAATQELLLQLQKDNRDGRQRKQELEKLMRGLE------AESESLNQRLQDLSERERSL 100
A +E +Q +++ R++ +E E+L + E A++++ ++L+ +E+E +
Sbjct: 2075 AAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAA- 2133
Query: 101 LRRRSQAAQPLQGEAREAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFY 160
RR+QA Q + ++AA E+ ++ E+ R K +EQ L+ Q EE Q
Sbjct: 2134 --RRAQAEQAALRQ-KQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL 2190
Query: 161 YGGELQSQKSTEQQLAAQLVTLQNEL--------ELAETKCAL----------------- 195
ELQ K+ + A Q ++ EL EL++ K +
Sbjct: 2191 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2250
Query: 196 ----QEEKLQQDALQTAEAWAIFQEQTVVLQVRPHSDA----------KEVQVKVMEAAE 241
+ EK++Q A + A QE + Q+ A KE V EA
Sbjct: 2251 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2310
Query: 242 ---ELDAWQSGRELCDGQLRGVQYSTESLMEEMA 272
E + Q +EL Q R +Q E + +++A
Sbjct: 2311 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLA 2344
Score = 50.8 bits (120), Expect = 2e-06
Identities = 61/250 (24%), Positives = 112/250 (44%), Gaps = 35/250 (14%)
Query: 52 QELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPL 111
Q L + ++ RQ ++E E+L R ++ ES+ Q +L+ R ++ + + L
Sbjct: 1462 QALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRAL 1521
Query: 112 QGEAREAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYYGGELQSQKST 171
Q A E R +AE RRL +AE + +RQ+Q E ELQS++++
Sbjct: 1522 Q--ALEELRLQAEEAERRLRQAE------VERARQVQVALETAQRSA---EAELQSKRAS 1570
Query: 172 EQQLAAQLV-TLQNE-------LELAETKCALQ--EEKLQQDALQTAEAWAIFQEQTVVL 221
+ AQL +LQ E E AE + Q E+ +++A + E W + + + L
Sbjct: 1571 FAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRL 1630
Query: 222 QVRPHSDAKEVQVKVMEAAE-----ELDAWQSG---------RELCDGQLRGVQYSTESL 267
+++ A++ + EA + E +A + G REL + +L + E
Sbjct: 1631 RLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGT 1690
Query: 268 MEEMARADRE 277
++ A++E
Sbjct: 1691 AQQRLAAEQE 1700
Score = 48.9 bits (115), Expect = 7e-06
Identities = 63/267 (23%), Positives = 114/267 (42%), Gaps = 57/267 (21%)
Query: 57 QLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSER----ERSLLRRRSQAAQPLQ 112
Q++++ R + +EL KL +EAE+ +L R +D ++R E +++ ++ A L
Sbjct: 2211 QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLS 2270
Query: 113 GEAREAARER---------------------------AERVRRRLEEAERHKEDLEQHSR 145
A+EAAR R A R++ E ++ KE ++ +R
Sbjct: 2271 VAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR 2330
Query: 146 QLQEQWEELSSQL------FYYGGELQSQKSTEQQLAAQLVTLQNELELAETKCALQE-- 197
+LQE E+++ QL F E + Q+ E A+ + L+ E++ + +E
Sbjct: 2331 RLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLR-VAEMSRAQARAEEDA 2389
Query: 198 -----------EKLQQDALQTAEAWAIFQEQTVVLQVRPHSDAKEVQVKVMEAAEELDAW 246
EKL + L T E + Q + Q H DA+ ++ + E E +
Sbjct: 2390 QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH-DAERLREAIAELEREKEKL 2448
Query: 247 QSGRELCDGQLRGVQYST---ESLMEE 270
Q +L QL+ + T E L++E
Sbjct: 2449 QQEAKLL--QLKSEEMQTVQQEQLLQE 2473
Score = 47.8 bits (112), Expect = 2e-05
Identities = 62/265 (23%), Positives = 107/265 (40%), Gaps = 30/265 (11%)
Query: 19 RRSLPPIVTPASRRLGPRGGRHL----GSVSTAMAATQELLLQLQKDNRDGRQRKQELEK 74
+ L P+ +PA + G + + T + L Q K + +R +E E+
Sbjct: 1276 KAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER 1335
Query: 75 LMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPLQGEAREAARERAERVRRRLEEAE 134
L AE ++ E++R L +QA + EA+E + E V RR E A
Sbjct: 1336 LAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA- 1394
Query: 135 RHKEDLEQHSRQLQEQWEELSSQLFYYGGELQSQKSTEQQLAAQLVTLQNELELAETKCA 194
D +Q R +QE+ ++L E + Q Q AA+ L+ E E+ +
Sbjct: 1395 ---VDAQQQKRSIQEELQQLRQ-----SSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ 1446
Query: 195 LQEEKLQQDALQTAEAWAIFQEQTVVLQVRPHSDAKEVQVKVMEAAEELDAWQSGRELCD 254
L+ + Q+ + E A+ + A+E + + +A EE + + R++ D
Sbjct: 1447 LEATERQRGGAE-GELQAL------------RARAEEAEAQKRQAQEEAERLR--RQVQD 1491
Query: 255 GQLRGVQYSTE--SLMEEMARADRE 277
R Q E S ++ A A RE
Sbjct: 1492 ESQRKRQAEVELASRVKAEAEAARE 1516
Score = 45.1 bits (105), Expect = 1e-04
Identities = 69/283 (24%), Positives = 110/283 (38%), Gaps = 64/283 (22%)
Query: 45 STAMAATQELLLQLQKD---------NRDGRQRKQELEKLMRGLEAESESLNQRLQDLS- 94
+T + A E LLQ QK+ D Q Q+L + +G + E+ QR ++S
Sbjct: 2308 ATRLKAEAE-LLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSA 2366
Query: 95 ERERSLLR---------RRSQAAQPLQGEARE----------AARER------------- 122
E ER LR R + AQ + +A E A +E+
Sbjct: 2367 EAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQ 2426
Query: 123 ----AERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYYGGELQSQKSTEQQLAAQ 178
AER+R + E ER KE L+Q ++ LQ + EE+ Q ++QL +
Sbjct: 2427 SDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM-------------QTVQQEQLLQE 2473
Query: 179 LVTLQNELELAETKCALQEEKLQQDALQTAEAWAIFQEQTVVLQVRPHSDAKEVQVKVME 238
LQ L+E LQ E+ + + A+ +FQ++ Q ++ Q E
Sbjct: 2474 TQALQQSF-LSEKDSLLQRERFIEQ--EKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQE 2530
Query: 239 AAEELDAWQSGRELCDGQLRGVQYSTESLME-EMARADRETRL 280
+ + + R GV+ E L + E R +E L
Sbjct: 2531 RQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELL 2573
Score = 43.5 bits (101), Expect = 3e-04
Identities = 70/286 (24%), Positives = 121/286 (42%), Gaps = 53/286 (18%)
Query: 32 RLGPRGGRHLGSVSTAMAATQELLLQLQKDNRDGRQRKQELEKLMRGLEAESES---LNQ 88
RL R G V +LL + Q R++ELE+L R L ES L
Sbjct: 1148 RLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGA 1207
Query: 89 RLQDLSERERSLLRRRSQAAQPLQGEAREAARERAERVRRRLEEAERHKEDLEQ---HSR 145
LQD RRR + Q + +A RE+ + + LEE ERH E +E+ ++
Sbjct: 1208 WLQDA--------RRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAK 1259
Query: 146 QLQEQWEELSSQLFYYGGELQS----------QKSTEQQLA---------AQLVTLQNE- 185
Q ++ QL Y +L+ Q +E + ++L TL ++
Sbjct: 1260 QYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQY 1319
Query: 186 -------LELAETKCALQEEKLQQDALQTAEAWAIFQEQTVVLQVRPHS------DAKEV 232
L E + L E++ ++ + AE A ++Q + + + +AKE+
Sbjct: 1320 IKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKEL 1379
Query: 233 QVKVMEAA---EE--LDAWQSGRELCDGQLRGVQYSTESLMEEMAR 273
Q ++ E EE +DA Q R + + +L+ ++ S+E+ ++ AR
Sbjct: 1380 QQRMQEEVVRREEAAVDAQQQKRSIQE-ELQQLRQSSEAEIQAKAR 1424
Score = 42.0 bits (97), Expect = 8e-04
Identities = 65/240 (27%), Positives = 105/240 (43%), Gaps = 53/240 (22%)
Query: 53 ELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQ------RLQDLSE---RERSLL-- 101
E+ + L R + + EK + LEAE+ + RL+ L+E R+R L
Sbjct: 1749 EMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE 1808
Query: 102 ---RRRSQAAQPLQ------GEA-------------REAARERAERV-------RRRLEE 132
R+R++A + L GEA +EA ER R+ RRRLEE
Sbjct: 1809 DAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEE 1868
Query: 133 -AERHKEDLEQHSRQLQEQWE-ELSSQLFYYGGELQSQKSTEQQLAAQLVTLQN------ 184
A +HK D+E+ QL++ + EL Q L+ ++ E+++ A + +
Sbjct: 1869 QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 1928
Query: 185 --ELELAETKCALQEEKLQQDALQTAEAWAIFQEQTVVLQVRPHSDAKEVQVKVMEAAEE 242
ELEL + + E+ L+ + + AE A Q Q + R +A+E K + A EE
Sbjct: 1929 ELELELGRIR-SNAEDTLR--SKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 1985
Score = 41.6 bits (96), Expect = 0.001
Identities = 40/159 (25%), Positives = 71/159 (44%), Gaps = 10/159 (6%)
Query: 67 QRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPLQGEAREAARERAERV 126
Q K +LE+L + A++ Q+L++ +R++ + + Q EAR E E V
Sbjct: 2497 QEKAKLEQLFQDEVAKA----QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV 2552
Query: 127 RRRLEEAERHKEDLEQHSRQLQEQWEELSSQL-----FYYGGELQSQKSTEQQLAAQLVT 181
RR+ EE ++ ++ Q L E+ + L QL + S++ T Q+AA T
Sbjct: 2553 RRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAA-TKT 2611
Query: 182 LQNELELAETKCALQEEKLQQDALQTAEAWAIFQEQTVV 220
L N + + A E + D L+ + QE ++
Sbjct: 2612 LPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGIL 2650
Score = 41.2 bits (95), Expect = 0.001
Identities = 33/139 (23%), Positives = 62/139 (44%), Gaps = 18/139 (12%)
Query: 52 QELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPL 111
++LL + Q + K L + R +E E L Q QD + + L + + Q +
Sbjct: 2468 EQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQM 2527
Query: 112 QGEAREAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYYGGELQSQKST 171
+ E +R+ +EEA R + + E+ R+ QE+ ++L Q ++
Sbjct: 2528 EQE--------RQRLVASMEEARRRQHEAEEGVRRKQEELQQLE----------QQRRQQ 2569
Query: 172 EQQLAAQLVTLQNELELAE 190
E+ LA + L+ +L+L E
Sbjct: 2570 EELLAEENQRLREQLQLLE 2588
Score = 38.1 bits (87), Expect = 0.012
Identities = 44/165 (26%), Positives = 77/165 (46%), Gaps = 38/165 (23%)
Query: 70 QELEKLMRGLEA---ESESLNQRLQDLSERERSL--LRRRSQAAQPLQGEARE---AARE 121
Q E+++R E E++++ L +L + SL LR +++A QP R+ A+E
Sbjct: 1085 QGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQE 1144
Query: 122 RAERVRRRLEEAERHKEDLEQHSRQLQEQW--------------EELSSQLFYY------ 161
ER+++R E + E + QL E+W E+L QL YY
Sbjct: 1145 VGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADP 1204
Query: 162 -GGELQSQKSTEQQLAAQLVTLQNELELAETKCALQEEKLQQDAL 205
G LQ + ++Q+ A + LA+++ A++E+ Q+ AL
Sbjct: 1205 LGAWLQDARRRQEQIQA--------MPLADSQ-AVREQLRQEQAL 1240
Score = 32.3 bits (72), Expect = 0.67
Identities = 27/110 (24%), Positives = 53/110 (48%), Gaps = 13/110 (11%)
Query: 52 QELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPL 111
Q+ + + Q+ + ++++Q++E+ + L A E +R + E +RR+ + Q L
Sbjct: 2507 QDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEG----VRRKQEELQQL 2562
Query: 112 QGEAR---EAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQL 158
+ + R E E +R+R +L+ E EQH L E +SQ+
Sbjct: 2563 EQQRRQQEELLAEENQRLREQLQLLE------EQHRAALAHSEEVTASQV 2606
Score = 32.0 bits (71), Expect = 0.87
Identities = 45/212 (21%), Positives = 91/212 (42%), Gaps = 34/212 (16%)
Query: 70 QELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPLQGEAREAARERAERVRRR 129
Q LE + + ++E L + + +L ERE+ L++ ++ Q E + +E+ + +
Sbjct: 2418 QTLEIQRQQSDHDAERLREAIAEL-EREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA 2476
Query: 130 LEEAERHKED--------LEQHSRQLQEQWEELSSQLFYYGGELQSQKSTEQQLAAQLVT 181
L+++ ++D +EQ +L++ +++ ++ E Q Q+ +Q +LV
Sbjct: 2477 LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVA 2536
Query: 182 ------------------LQNELELAETKCALQEEKLQQDALQTAEAWAIFQEQTVVLQV 223
Q EL+ E + QEE L ++ + E + +EQ
Sbjct: 2537 SMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQH--RAA 2594
Query: 224 RPHSDAKEVQVKVMEAAEELDAWQSGRELCDG 255
HS+ EV + A + L +GR+ DG
Sbjct: 2595 LAHSE--EVTASQVAATKTL---PNGRDALDG 2621
Score = 30.0 bits (66), Expect = 3.3
Identities = 63/282 (22%), Positives = 105/282 (37%), Gaps = 73/282 (25%)
Query: 52 QELLLQLQKDNRD-GRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLR-------- 102
QE +LQ+D +Q +E + R LEAE + ++L+ +E ER LR
Sbjct: 2326 QEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ---RQLEMSAEAERLKLRVAEMSRAQ 2382
Query: 103 -RRSQAAQPLQGEARE----------AARER-----------------AERVRRRLEEAE 134
R + AQ + +A E A +E+ AER+R + E E
Sbjct: 2383 ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE 2442
Query: 135 RHKEDLEQH----------------------SRQLQEQWEELSSQLFYYGGELQSQKSTE 172
R KE L+Q ++ LQ+ + L LQ ++ E
Sbjct: 2443 REKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL------LQRERFIE 2496
Query: 173 QQLAAQLVTLQNELELAETKCALQEEKLQQDALQTAEAWAIFQEQTVVLQVRPHSDAKEV 232
Q+ A Q+E+ A+ Q+ + QQ + A +E R +A+E
Sbjct: 2497 QEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR-----RRQHEAEEG 2551
Query: 233 QVKVMEAAEELDAWQSGRELCDGQLRGVQYSTESLMEEMARA 274
+ E ++L+ + +E + L+EE RA
Sbjct: 2552 VRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRA 2593
Score = 28.9 bits (63), Expect = 7.4
Identities = 31/113 (27%), Positives = 48/113 (42%), Gaps = 22/113 (19%)
Query: 48 MAATQELLLQLQKDNRDGRQRKQE----LEKLMRGLEA----ESESLNQRLQDLSERERS 99
+ A+ E + Q + +G +RKQE LE+ R E E++ L ++LQ L E+ R+
Sbjct: 2534 LVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRA 2593
Query: 100 LLRRRSQAA--------------QPLQGEAREAARERAERVRRRLEEAERHKE 138
L + L G A EA E + RR A+R +E
Sbjct: 2594 ALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQE 2646
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 61.6 bits (148), Expect = 1e-09
Identities = 73/249 (29%), Positives = 115/249 (46%), Gaps = 19/249 (7%)
Query: 47 AMAATQELLLQLQKDNRDGRQRKQE--------LEKLMRGLEAESESLNQRLQD-LSERE 97
A+ A +EL LQ ++ R RQ + E LE R EAE +S + ++ E
Sbjct: 1561 ALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE 1620
Query: 98 RSLLRRRSQAAQPLQGEAREAARERAERVRRRLEEAERHKEDLEQHSRQ---LQEQWEEL 154
RSL AQ L+ EA A+++AE R R EEAER E + + + L+ Q EE+
Sbjct: 1621 RSLQEEHVAVAQ-LREEAERRAQQQAEAERAR-EEAERELERWQLKANEALRLRLQAEEV 1678
Query: 155 SSQLFYYGGELQSQKSTEQQLAAQLVTLQNELELAETKCALQE-EKLQQDALQTAEAWAI 213
+ Q E + QK E + A+ E + + + A QE EK +Q A TA+
Sbjct: 1679 AQQKSLAQAEAEKQKE-EAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLA 1737
Query: 214 FQEQTVVLQVRPHSDAKEVQVKVMEAAE---ELDAWQSGRELCDGQLRGVQYSTESLMEE 270
+++ + L+ ++ Q+ E A E A R+ + +L V+ E L+
Sbjct: 1738 AEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLAS 1797
Query: 271 MARADRETR 279
ARA+ E+R
Sbjct: 1798 KARAEEESR 1806
Score = 56.2 bits (134), Expect = 4e-08
Identities = 72/261 (27%), Positives = 105/261 (40%), Gaps = 32/261 (12%)
Query: 43 SVSTAMAATQELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQR-LQDLSERERSLL 101
S A A EL L+L GR R + L +AE E+ QR L ER R
Sbjct: 1960 SFEKAAAGKAELELEL------GRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREA 2013
Query: 102 RRRSQAAQPLQGEA---REAARERAERVRRRLEEAERHKEDLEQHS-RQLQEQWEELSSQ 157
R Q + + EA R+AA E ER++ ++EEA R +E EQ S RQLQ E +
Sbjct: 2014 EERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKR 2073
Query: 158 L--------FYYGGELQSQKSTEQQLAAQLVTLQNELELAETKCALQEE-------KLQQ 202
L F + Q + T QQ + L L+ E E A EE + Q
Sbjct: 2074 LQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQ 2133
Query: 203 DALQTAEAWAIFQEQTVVLQVRPHSDA------KEVQVKVMEAAEELDAWQSGRELCDGQ 256
Q EA + Q Q R + A KE + + A+ A ++ D +
Sbjct: 2134 SRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAE 2193
Query: 257 LRGVQYSTESLMEEMARADRE 277
+ + E + + A+ ++E
Sbjct: 2194 MEKHKKFAEQTLRQKAQVEQE 2214
Score = 54.7 bits (130), Expect = 1e-07
Identities = 47/157 (29%), Positives = 77/157 (49%), Gaps = 5/157 (3%)
Query: 52 QELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPL 111
+E L +LQ++ Q++QELE + + AE E L E RS + Q +
Sbjct: 1760 EEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAE 1819
Query: 112 QGEAREAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYYGGELQSQKST 171
G RE A E A R+R EEA+R ++ E+ + + + + E + ++ GE K T
Sbjct: 1820 AGRFRELA-EEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLK-T 1877
Query: 172 EQQLAAQLVTLQNE--LELAETKCALQEEKLQQDALQ 206
E ++A + +NE LAE + A Q +L++ A Q
Sbjct: 1878 EAEIALKEKEAENERLRRLAEDE-AFQRRRLEEQAAQ 1913
Score = 52.4 bits (124), Expect = 6e-07
Identities = 64/274 (23%), Positives = 114/274 (41%), Gaps = 52/274 (18%)
Query: 47 AMAATQELLLQLQKDNRDGRQRKQELEKLMRGLE------AESESLNQRLQDLSERERSL 100
A +E +Q +++ R++ +E E+L + E A++++ ++L+ +E+E +
Sbjct: 2116 AAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAA- 2174
Query: 101 LRRRSQAAQPLQGEAREAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFY 160
RR+QA Q + ++AA E+ ++ E+ R K +EQ L+ Q EE Q
Sbjct: 2175 --RRAQAEQAALRQ-KQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL 2231
Query: 161 YGGELQSQKSTEQQLAAQLVTLQNEL--------ELAETKCAL----------------- 195
ELQ K+ + A Q ++ EL EL++ K +
Sbjct: 2232 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2291
Query: 196 ----QEEKLQQDALQTAEAWAIFQEQTVVLQVRPHSDA----------KEVQVKVMEAAE 241
+ EK++Q A + A QE + Q+ A KE V EA
Sbjct: 2292 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2351
Query: 242 ---ELDAWQSGRELCDGQLRGVQYSTESLMEEMA 272
E + Q +EL Q R +Q E + +++A
Sbjct: 2352 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLA 2385
Score = 50.8 bits (120), Expect = 2e-06
Identities = 61/250 (24%), Positives = 112/250 (44%), Gaps = 35/250 (14%)
Query: 52 QELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPL 111
Q L + ++ RQ ++E E+L R ++ ES+ Q +L+ R ++ + + L
Sbjct: 1503 QALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRAL 1562
Query: 112 QGEAREAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYYGGELQSQKST 171
Q A E R +AE RRL +AE + +RQ+Q E ELQS++++
Sbjct: 1563 Q--ALEELRLQAEEAERRLRQAE------VERARQVQVALETAQRSA---EAELQSKRAS 1611
Query: 172 EQQLAAQLV-TLQNE-------LELAETKCALQ--EEKLQQDALQTAEAWAIFQEQTVVL 221
+ AQL +LQ E E AE + Q E+ +++A + E W + + + L
Sbjct: 1612 FAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRL 1671
Query: 222 QVRPHSDAKEVQVKVMEAAE-----ELDAWQSG---------RELCDGQLRGVQYSTESL 267
+++ A++ + EA + E +A + G REL + +L + E
Sbjct: 1672 RLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGT 1731
Query: 268 MEEMARADRE 277
++ A++E
Sbjct: 1732 AQQRLAAEQE 1741
Score = 48.9 bits (115), Expect = 7e-06
Identities = 63/267 (23%), Positives = 114/267 (42%), Gaps = 57/267 (21%)
Query: 57 QLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSER----ERSLLRRRSQAAQPLQ 112
Q++++ R + +EL KL +EAE+ +L R +D ++R E +++ ++ A L
Sbjct: 2252 QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLS 2311
Query: 113 GEAREAARER---------------------------AERVRRRLEEAERHKEDLEQHSR 145
A+EAAR R A R++ E ++ KE ++ +R
Sbjct: 2312 VAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR 2371
Query: 146 QLQEQWEELSSQL------FYYGGELQSQKSTEQQLAAQLVTLQNELELAETKCALQE-- 197
+LQE E+++ QL F E + Q+ E A+ + L+ E++ + +E
Sbjct: 2372 RLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLR-VAEMSRAQARAEEDA 2430
Query: 198 -----------EKLQQDALQTAEAWAIFQEQTVVLQVRPHSDAKEVQVKVMEAAEELDAW 246
EKL + L T E + Q + Q H DA+ ++ + E E +
Sbjct: 2431 QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH-DAERLREAIAELEREKEKL 2489
Query: 247 QSGRELCDGQLRGVQYST---ESLMEE 270
Q +L QL+ + T E L++E
Sbjct: 2490 QQEAKLL--QLKSEEMQTVQQEQLLQE 2514
Score = 47.8 bits (112), Expect = 2e-05
Identities = 62/265 (23%), Positives = 107/265 (40%), Gaps = 30/265 (11%)
Query: 19 RRSLPPIVTPASRRLGPRGGRHL----GSVSTAMAATQELLLQLQKDNRDGRQRKQELEK 74
+ L P+ +PA + G + + T + L Q K + +R +E E+
Sbjct: 1317 KAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER 1376
Query: 75 LMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPLQGEAREAARERAERVRRRLEEAE 134
L AE ++ E++R L +QA + EA+E + E V RR E A
Sbjct: 1377 LAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA- 1435
Query: 135 RHKEDLEQHSRQLQEQWEELSSQLFYYGGELQSQKSTEQQLAAQLVTLQNELELAETKCA 194
D +Q R +QE+ ++L E + Q Q AA+ L+ E E+ +
Sbjct: 1436 ---VDAQQQKRSIQEELQQLRQ-----SSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ 1487
Query: 195 LQEEKLQQDALQTAEAWAIFQEQTVVLQVRPHSDAKEVQVKVMEAAEELDAWQSGRELCD 254
L+ + Q+ + E A+ + A+E + + +A EE + + R++ D
Sbjct: 1488 LEATERQRGGAE-GELQAL------------RARAEEAEAQKRQAQEEAERLR--RQVQD 1532
Query: 255 GQLRGVQYSTE--SLMEEMARADRE 277
R Q E S ++ A A RE
Sbjct: 1533 ESQRKRQAEVELASRVKAEAEAARE 1557
Score = 45.1 bits (105), Expect = 1e-04
Identities = 69/283 (24%), Positives = 110/283 (38%), Gaps = 64/283 (22%)
Query: 45 STAMAATQELLLQLQKD---------NRDGRQRKQELEKLMRGLEAESESLNQRLQDLS- 94
+T + A E LLQ QK+ D Q Q+L + +G + E+ QR ++S
Sbjct: 2349 ATRLKAEAE-LLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSA 2407
Query: 95 ERERSLLR---------RRSQAAQPLQGEARE----------AARER------------- 122
E ER LR R + AQ + +A E A +E+
Sbjct: 2408 EAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQ 2467
Query: 123 ----AERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYYGGELQSQKSTEQQLAAQ 178
AER+R + E ER KE L+Q ++ LQ + EE+ Q ++QL +
Sbjct: 2468 SDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM-------------QTVQQEQLLQE 2514
Query: 179 LVTLQNELELAETKCALQEEKLQQDALQTAEAWAIFQEQTVVLQVRPHSDAKEVQVKVME 238
LQ L+E LQ E+ + + A+ +FQ++ Q ++ Q E
Sbjct: 2515 TQALQQSF-LSEKDSLLQRERFIEQ--EKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQE 2571
Query: 239 AAEELDAWQSGRELCDGQLRGVQYSTESLME-EMARADRETRL 280
+ + + R GV+ E L + E R +E L
Sbjct: 2572 RQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELL 2614
Score = 43.5 bits (101), Expect = 3e-04
Identities = 70/286 (24%), Positives = 121/286 (42%), Gaps = 53/286 (18%)
Query: 32 RLGPRGGRHLGSVSTAMAATQELLLQLQKDNRDGRQRKQELEKLMRGLEAESES---LNQ 88
RL R G V +LL + Q R++ELE+L R L ES L
Sbjct: 1189 RLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGA 1248
Query: 89 RLQDLSERERSLLRRRSQAAQPLQGEAREAARERAERVRRRLEEAERHKEDLEQ---HSR 145
LQD RRR + Q + +A RE+ + + LEE ERH E +E+ ++
Sbjct: 1249 WLQDA--------RRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAK 1300
Query: 146 QLQEQWEELSSQLFYYGGELQS----------QKSTEQQLA---------AQLVTLQNE- 185
Q ++ QL Y +L+ Q +E + ++L TL ++
Sbjct: 1301 QYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQY 1360
Query: 186 -------LELAETKCALQEEKLQQDALQTAEAWAIFQEQTVVLQVRPHS------DAKEV 232
L E + L E++ ++ + AE A ++Q + + + +AKE+
Sbjct: 1361 IKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKEL 1420
Query: 233 QVKVMEAA---EE--LDAWQSGRELCDGQLRGVQYSTESLMEEMAR 273
Q ++ E EE +DA Q R + + +L+ ++ S+E+ ++ AR
Sbjct: 1421 QQRMQEEVVRREEAAVDAQQQKRSIQE-ELQQLRQSSEAEIQAKAR 1465
Score = 42.0 bits (97), Expect = 8e-04
Identities = 65/240 (27%), Positives = 105/240 (43%), Gaps = 53/240 (22%)
Query: 53 ELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQ------RLQDLSE---RERSLL-- 101
E+ + L R + + EK + LEAE+ + RL+ L+E R+R L
Sbjct: 1790 EMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE 1849
Query: 102 ---RRRSQAAQPLQ------GEA-------------REAARERAERV-------RRRLEE 132
R+R++A + L GEA +EA ER R+ RRRLEE
Sbjct: 1850 DAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEE 1909
Query: 133 -AERHKEDLEQHSRQLQEQWE-ELSSQLFYYGGELQSQKSTEQQLAAQLVTLQN------ 184
A +HK D+E+ QL++ + EL Q L+ ++ E+++ A + +
Sbjct: 1910 QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 1969
Query: 185 --ELELAETKCALQEEKLQQDALQTAEAWAIFQEQTVVLQVRPHSDAKEVQVKVMEAAEE 242
ELEL + + E+ L+ + + AE A Q Q + R +A+E K + A EE
Sbjct: 1970 ELELELGRIR-SNAEDTLR--SKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 2026
Score = 41.6 bits (96), Expect = 0.001
Identities = 40/159 (25%), Positives = 71/159 (44%), Gaps = 10/159 (6%)
Query: 67 QRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPLQGEAREAARERAERV 126
Q K +LE+L + A++ Q+L++ +R++ + + Q EAR E E V
Sbjct: 2538 QEKAKLEQLFQDEVAKA----QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV 2593
Query: 127 RRRLEEAERHKEDLEQHSRQLQEQWEELSSQL-----FYYGGELQSQKSTEQQLAAQLVT 181
RR+ EE ++ ++ Q L E+ + L QL + S++ T Q+AA T
Sbjct: 2594 RRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAA-TKT 2652
Query: 182 LQNELELAETKCALQEEKLQQDALQTAEAWAIFQEQTVV 220
L N + + A E + D L+ + QE ++
Sbjct: 2653 LPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGIL 2691
Score = 41.2 bits (95), Expect = 0.001
Identities = 33/139 (23%), Positives = 62/139 (44%), Gaps = 18/139 (12%)
Query: 52 QELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPL 111
++LL + Q + K L + R +E E L Q QD + + L + + Q +
Sbjct: 2509 EQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQM 2568
Query: 112 QGEAREAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYYGGELQSQKST 171
+ E +R+ +EEA R + + E+ R+ QE+ ++L Q ++
Sbjct: 2569 EQE--------RQRLVASMEEARRRQHEAEEGVRRKQEELQQLE----------QQRRQQ 2610
Query: 172 EQQLAAQLVTLQNELELAE 190
E+ LA + L+ +L+L E
Sbjct: 2611 EELLAEENQRLREQLQLLE 2629
Score = 38.1 bits (87), Expect = 0.012
Identities = 44/165 (26%), Positives = 77/165 (46%), Gaps = 38/165 (23%)
Query: 70 QELEKLMRGLEA---ESESLNQRLQDLSERERSL--LRRRSQAAQPLQGEARE---AARE 121
Q E+++R E E++++ L +L + SL LR +++A QP R+ A+E
Sbjct: 1126 QGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQE 1185
Query: 122 RAERVRRRLEEAERHKEDLEQHSRQLQEQW--------------EELSSQLFYY------ 161
ER+++R E + E + QL E+W E+L QL YY
Sbjct: 1186 VGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADP 1245
Query: 162 -GGELQSQKSTEQQLAAQLVTLQNELELAETKCALQEEKLQQDAL 205
G LQ + ++Q+ A + LA+++ A++E+ Q+ AL
Sbjct: 1246 LGAWLQDARRRQEQIQA--------MPLADSQ-AVREQLRQEQAL 1281
Score = 32.3 bits (72), Expect = 0.67
Identities = 27/110 (24%), Positives = 53/110 (48%), Gaps = 13/110 (11%)
Query: 52 QELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPL 111
Q+ + + Q+ + ++++Q++E+ + L A E +R + E +RR+ + Q L
Sbjct: 2548 QDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEG----VRRKQEELQQL 2603
Query: 112 QGEAR---EAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQL 158
+ + R E E +R+R +L+ E EQH L E +SQ+
Sbjct: 2604 EQQRRQQEELLAEENQRLREQLQLLE------EQHRAALAHSEEVTASQV 2647
Score = 32.0 bits (71), Expect = 0.87
Identities = 45/212 (21%), Positives = 91/212 (42%), Gaps = 34/212 (16%)
Query: 70 QELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPLQGEAREAARERAERVRRR 129
Q LE + + ++E L + + +L ERE+ L++ ++ Q E + +E+ + +
Sbjct: 2459 QTLEIQRQQSDHDAERLREAIAEL-EREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA 2517
Query: 130 LEEAERHKED--------LEQHSRQLQEQWEELSSQLFYYGGELQSQKSTEQQLAAQLVT 181
L+++ ++D +EQ +L++ +++ ++ E Q Q+ +Q +LV
Sbjct: 2518 LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVA 2577
Query: 182 ------------------LQNELELAETKCALQEEKLQQDALQTAEAWAIFQEQTVVLQV 223
Q EL+ E + QEE L ++ + E + +EQ
Sbjct: 2578 SMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQH--RAA 2635
Query: 224 RPHSDAKEVQVKVMEAAEELDAWQSGRELCDG 255
HS+ EV + A + L +GR+ DG
Sbjct: 2636 LAHSE--EVTASQVAATKTL---PNGRDALDG 2662
Score = 30.0 bits (66), Expect = 3.3
Identities = 63/282 (22%), Positives = 105/282 (37%), Gaps = 73/282 (25%)
Query: 52 QELLLQLQKDNRD-GRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLR-------- 102
QE +LQ+D +Q +E + R LEAE + ++L+ +E ER LR
Sbjct: 2367 QEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ---RQLEMSAEAERLKLRVAEMSRAQ 2423
Query: 103 -RRSQAAQPLQGEARE----------AARER-----------------AERVRRRLEEAE 134
R + AQ + +A E A +E+ AER+R + E E
Sbjct: 2424 ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE 2483
Query: 135 RHKEDLEQH----------------------SRQLQEQWEELSSQLFYYGGELQSQKSTE 172
R KE L+Q ++ LQ+ + L LQ ++ E
Sbjct: 2484 REKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL------LQRERFIE 2537
Query: 173 QQLAAQLVTLQNELELAETKCALQEEKLQQDALQTAEAWAIFQEQTVVLQVRPHSDAKEV 232
Q+ A Q+E+ A+ Q+ + QQ + A +E R +A+E
Sbjct: 2538 QEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR-----RRQHEAEEG 2592
Query: 233 QVKVMEAAEELDAWQSGRELCDGQLRGVQYSTESLMEEMARA 274
+ E ++L+ + +E + L+EE RA
Sbjct: 2593 VRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRA 2634
Score = 28.9 bits (63), Expect = 7.4
Identities = 31/113 (27%), Positives = 48/113 (42%), Gaps = 22/113 (19%)
Query: 48 MAATQELLLQLQKDNRDGRQRKQE----LEKLMRGLEA----ESESLNQRLQDLSERERS 99
+ A+ E + Q + +G +RKQE LE+ R E E++ L ++LQ L E+ R+
Sbjct: 2575 LVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRA 2634
Query: 100 LLRRRSQAA--------------QPLQGEAREAARERAERVRRRLEEAERHKE 138
L + L G A EA E + RR A+R +E
Sbjct: 2635 ALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQE 2687
>gi|42794779 myosin 18A isoform b [Homo sapiens]
Length = 2039
Score = 60.8 bits (146), Expect = 2e-09
Identities = 60/238 (25%), Positives = 104/238 (43%), Gaps = 23/238 (9%)
Query: 58 LQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPLQGEARE 117
LQ D+ + ++ Q+L+K + L AE + L+ R L +++ + L E
Sbjct: 1414 LQADSEESQRALQQLKKKCQRLTAELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEE 1473
Query: 118 AARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEE-------LSSQLFYYGGELQSQKS 170
A RE+ +R E+ +R K+ L + L++Q EE + ++ ELQ S
Sbjct: 1474 AQREKLQR-----EKLQREKDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISS 1528
Query: 171 TEQQLAAQLVTLQNELELAETKCALQEEKLQQDA--LQTAEAWAIFQEQTVVLQVRPHSD 228
E + A L ++ +L E K QEE+L + A +Q E + E + + HS
Sbjct: 1529 QESKDEASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEMERMRQTHS- 1587
Query: 229 AKEVQVKVMEAAEELDAWQSGRELCDGQLRGVQYSTESLMEEMARADRETRLFGGPRA 286
K ME+ +E + R+ C +L+ ++ E E+ + RE R G A
Sbjct: 1588 ------KEMESRDE--EVEEARQSCQKKLKQMEVQLEEEYEDKQKVLREKRELEGKLA 1637
Score = 44.3 bits (103), Expect = 2e-04
Identities = 55/246 (22%), Positives = 108/246 (43%), Gaps = 27/246 (10%)
Query: 47 AMAATQELLLQLQKDN----RDGRQRKQELE----------KLMRGLEAESESLNQRLQD 92
A+ A +L+L K++ R+ Q K +LE K + +E E E L+ ++ D
Sbjct: 1663 ALLADAQLMLDHLKNSAPSKREIAQLKNQLEESEFTCAAAVKARKAMEVEIEDLHLQIDD 1722
Query: 93 LSERERSLLRRRSQAAQPLQGEAREAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWE 152
+++ + +L + S+ LQ E E ++ RLEE + +L + + Q
Sbjct: 1723 IAKAKTALEEQLSR----LQREKNE--------IQNRLEEDQEDMNELMKKHKAAVAQAS 1770
Query: 153 ELSSQLFYYGGELQSQKSTEQQLAAQLVTLQNELELAETKCALQEEKLQQDA-LQTAEAW 211
+Q+ +L+ +Q+L +L LQ+++E E + +Q+A ++ E
Sbjct: 1771 RDLAQINDLQAQLEEANKEKQELQEKLQALQSQVEFLEQSMVDKSLVSRQEAKIRELETR 1830
Query: 212 AIFQEQTVVLQVRPHSDAKEVQVKVMEAAEELDAWQSGRELCDGQLRGVQYSTESLMEEM 271
F+ V S KE K+ E ++ A ++ + + +L+ T+ M E+
Sbjct: 1831 LEFERTQVKRLESLASRLKENMEKLTEERDQRIAAENREKEQNKRLQRQLRDTKEEMGEL 1890
Query: 272 ARADRE 277
AR + E
Sbjct: 1891 ARKEAE 1896
Score = 39.7 bits (91), Expect = 0.004
Identities = 55/273 (20%), Positives = 109/273 (39%), Gaps = 48/273 (17%)
Query: 49 AATQELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQ-------------RLQDLSE 95
A Q++ Q KD + K++L L ++ + E L++ RL+ E
Sbjct: 1521 AELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEME 1580
Query: 96 RERSLLRRRSQAAQPLQGEAREAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELS 155
R R + ++ EAR++ +++ +++ +LEE K+ + + R+L+ + LS
Sbjct: 1581 RMRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQLEEEYEDKQKVLREKRELEGKLATLS 1640
Query: 156 SQLFYYGGELQSQ-----KSTEQQLA----------------AQLVTLQNELELAETKCA 194
Q+ E + + K T+ LA ++ L+N+LE +E CA
Sbjct: 1641 DQVNRRDFESEKRLRKDLKRTKALLADAQLMLDHLKNSAPSKREIAQLKNQLEESEFTCA 1700
Query: 195 ----------LQEEKLQQDALQTAEAWAIFQEQTVVLQVRPHSDAKEVQVKVMEAAEELD 244
++ E L A+A +EQ LQ + E+Q ++ E E+++
Sbjct: 1701 AAVKARKAMEVEIEDLHLQIDDIAKAKTALEEQLSRLQ----REKNEIQNRLEEDQEDMN 1756
Query: 245 AWQSGRELCDGQLRGVQYSTESLMEEMARADRE 277
+ Q L ++ A++E
Sbjct: 1757 ELMKKHKAAVAQASRDLAQINDLQAQLEEANKE 1789
Score = 37.4 bits (85), Expect = 0.021
Identities = 59/247 (23%), Positives = 109/247 (44%), Gaps = 22/247 (8%)
Query: 44 VSTAMAATQELLLQLQKDNRDGRQRKQELEKLMRGLEAE----SESLNQRLQDLSERERS 99
V A + Q+ L Q++ + + KQ++ + R LE + S+ +N+R + +R R
Sbjct: 1597 VEEARQSCQKKLKQMEVQLEEEYEDKQKVLREKRELEGKLATLSDQVNRRDFESEKRLRK 1656
Query: 100 LLRRRSQA---AQPLQGEAREAARERAE--RVRRRLEEAERHKEDLEQHSRQLQEQWEEL 154
L+R AQ + + +A + E +++ +LEE+E + + ++ + E+L
Sbjct: 1657 DLKRTKALLADAQLMLDHLKNSAPSKREIAQLKNQLEESEFTCAAAVKARKAMEVEIEDL 1716
Query: 155 SSQLFYYGGELQSQKSTEQQLAAQLVTLQNELELAETKCALQEEKLQQDALQTAEAWAIF 214
Q+ ++ K+ L QL LQ E E + L+E++ + L A+
Sbjct: 1717 HLQI----DDIAKAKTA---LEEQLSRLQREKN--EIQNRLEEDQEDMNELMKKHKAAVA 1767
Query: 215 QEQTVVLQVRP-HSDAKEVQVKVMEAAEELDAWQSGRELCDGQLRGVQYSTESLMEEMAR 273
Q + Q+ + +E + E E+L A QS E + + V S S E R
Sbjct: 1768 QASRDLAQINDLQAQLEEANKEKQELQEKLQALQSQVEFLEQSM--VDKSLVSRQEAKIR 1825
Query: 274 ADRETRL 280
+ ETRL
Sbjct: 1826 -ELETRL 1831
Score = 35.8 bits (81), Expect = 0.061
Identities = 38/169 (22%), Positives = 75/169 (44%), Gaps = 22/169 (13%)
Query: 56 LQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSER--ERSLLRRRSQAAQP--- 110
L+ Q+D + R + RG A +++QDL+ R ++++ + + P
Sbjct: 1180 LEEQRDEQTSRNLTL-FQAACRGYLARQHFKKRKIQDLAIRCVQKNIKKNKGVKDWPWWK 1238
Query: 111 ------------LQGEAREAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQL 158
L E E +++R +LE+AE+ + +L +S +L+ + EL+S+L
Sbjct: 1239 LFTTVRPLIEVQLSEEQIRNKDEEIQQLRSKLEKAEKERNELRLNSDRLESRISELTSEL 1298
Query: 159 FYYGGELQSQKSTEQQLAAQLV-TLQNELELAETKCALQEEKLQQDALQ 206
E + +S Q L A+ L+ E E+ E + K Q + ++
Sbjct: 1299 ---TDERNTGESASQLLDAETAERLRAEKEMKELQTQYDALKKQMEVME 1344
Score = 35.8 bits (81), Expect = 0.061
Identities = 39/168 (23%), Positives = 72/168 (42%), Gaps = 17/168 (10%)
Query: 53 ELLLQLQKDNRDGRQRKQEL----------EKLMRGLEAESESLNQRLQDLSERERSLLR 102
EL +L + G Q L EK M+ L+ + ++L ++++ + E ++
Sbjct: 1293 ELTSELTDERNTGESASQLLDAETAERLRAEKEMKELQTQYDALKKQMEVM---EMEVME 1349
Query: 103 RRSQAAQPLQGEARE--AARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFY 160
R A + GE + A E + R + E + K+ L+Q E ++ QL
Sbjct: 1350 ARLIRAAEINGEVDDDDAGGEWRLKYERAVREVDFTKKRLQQEFEDKLEVEQQNKRQLER 1409
Query: 161 YGGELQSQKSTEQQLAAQLVTLQNEL--ELAETKCALQEEKLQQDALQ 206
G+LQ+ Q+ QL L EL +TK L+ ++++ L+
Sbjct: 1410 RLGDLQADSEESQRALQQLKKKCQRLTAELQDTKLHLEGQQVRNHELE 1457
>gi|28416946 myosin 18A isoform a [Homo sapiens]
Length = 2054
Score = 60.8 bits (146), Expect = 2e-09
Identities = 60/238 (25%), Positives = 104/238 (43%), Gaps = 23/238 (9%)
Query: 58 LQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPLQGEARE 117
LQ D+ + ++ Q+L+K + L AE + L+ R L +++ + L E
Sbjct: 1414 LQADSEESQRALQQLKKKCQRLTAELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEE 1473
Query: 118 AARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEE-------LSSQLFYYGGELQSQKS 170
A RE+ +R E+ +R K+ L + L++Q EE + ++ ELQ S
Sbjct: 1474 AQREKLQR-----EKLQREKDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISS 1528
Query: 171 TEQQLAAQLVTLQNELELAETKCALQEEKLQQDA--LQTAEAWAIFQEQTVVLQVRPHSD 228
E + A L ++ +L E K QEE+L + A +Q E + E + + HS
Sbjct: 1529 QESKDEASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEMERMRQTHS- 1587
Query: 229 AKEVQVKVMEAAEELDAWQSGRELCDGQLRGVQYSTESLMEEMARADRETRLFGGPRA 286
K ME+ +E + R+ C +L+ ++ E E+ + RE R G A
Sbjct: 1588 ------KEMESRDE--EVEEARQSCQKKLKQMEVQLEEEYEDKQKVLREKRELEGKLA 1637
Score = 44.3 bits (103), Expect = 2e-04
Identities = 55/246 (22%), Positives = 108/246 (43%), Gaps = 27/246 (10%)
Query: 47 AMAATQELLLQLQKDN----RDGRQRKQELE----------KLMRGLEAESESLNQRLQD 92
A+ A +L+L K++ R+ Q K +LE K + +E E E L+ ++ D
Sbjct: 1663 ALLADAQLMLDHLKNSAPSKREIAQLKNQLEESEFTCAAAVKARKAMEVEIEDLHLQIDD 1722
Query: 93 LSERERSLLRRRSQAAQPLQGEAREAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWE 152
+++ + +L + S+ LQ E E ++ RLEE + +L + + Q
Sbjct: 1723 IAKAKTALEEQLSR----LQREKNE--------IQNRLEEDQEDMNELMKKHKAAVAQAS 1770
Query: 153 ELSSQLFYYGGELQSQKSTEQQLAAQLVTLQNELELAETKCALQEEKLQQDA-LQTAEAW 211
+Q+ +L+ +Q+L +L LQ+++E E + +Q+A ++ E
Sbjct: 1771 RDLAQINDLQAQLEEANKEKQELQEKLQALQSQVEFLEQSMVDKSLVSRQEAKIRELETR 1830
Query: 212 AIFQEQTVVLQVRPHSDAKEVQVKVMEAAEELDAWQSGRELCDGQLRGVQYSTESLMEEM 271
F+ V S KE K+ E ++ A ++ + + +L+ T+ M E+
Sbjct: 1831 LEFERTQVKRLESLASRLKENMEKLTEERDQRIAAENREKEQNKRLQRQLRDTKEEMGEL 1890
Query: 272 ARADRE 277
AR + E
Sbjct: 1891 ARKEAE 1896
Score = 39.7 bits (91), Expect = 0.004
Identities = 55/273 (20%), Positives = 109/273 (39%), Gaps = 48/273 (17%)
Query: 49 AATQELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQ-------------RLQDLSE 95
A Q++ Q KD + K++L L ++ + E L++ RL+ E
Sbjct: 1521 AELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEME 1580
Query: 96 RERSLLRRRSQAAQPLQGEAREAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELS 155
R R + ++ EAR++ +++ +++ +LEE K+ + + R+L+ + LS
Sbjct: 1581 RMRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQLEEEYEDKQKVLREKRELEGKLATLS 1640
Query: 156 SQLFYYGGELQSQ-----KSTEQQLA----------------AQLVTLQNELELAETKCA 194
Q+ E + + K T+ LA ++ L+N+LE +E CA
Sbjct: 1641 DQVNRRDFESEKRLRKDLKRTKALLADAQLMLDHLKNSAPSKREIAQLKNQLEESEFTCA 1700
Query: 195 ----------LQEEKLQQDALQTAEAWAIFQEQTVVLQVRPHSDAKEVQVKVMEAAEELD 244
++ E L A+A +EQ LQ + E+Q ++ E E+++
Sbjct: 1701 AAVKARKAMEVEIEDLHLQIDDIAKAKTALEEQLSRLQ----REKNEIQNRLEEDQEDMN 1756
Query: 245 AWQSGRELCDGQLRGVQYSTESLMEEMARADRE 277
+ Q L ++ A++E
Sbjct: 1757 ELMKKHKAAVAQASRDLAQINDLQAQLEEANKE 1789
Score = 37.4 bits (85), Expect = 0.021
Identities = 59/247 (23%), Positives = 109/247 (44%), Gaps = 22/247 (8%)
Query: 44 VSTAMAATQELLLQLQKDNRDGRQRKQELEKLMRGLEAE----SESLNQRLQDLSERERS 99
V A + Q+ L Q++ + + KQ++ + R LE + S+ +N+R + +R R
Sbjct: 1597 VEEARQSCQKKLKQMEVQLEEEYEDKQKVLREKRELEGKLATLSDQVNRRDFESEKRLRK 1656
Query: 100 LLRRRSQA---AQPLQGEAREAARERAE--RVRRRLEEAERHKEDLEQHSRQLQEQWEEL 154
L+R AQ + + +A + E +++ +LEE+E + + ++ + E+L
Sbjct: 1657 DLKRTKALLADAQLMLDHLKNSAPSKREIAQLKNQLEESEFTCAAAVKARKAMEVEIEDL 1716
Query: 155 SSQLFYYGGELQSQKSTEQQLAAQLVTLQNELELAETKCALQEEKLQQDALQTAEAWAIF 214
Q+ ++ K+ L QL LQ E E + L+E++ + L A+
Sbjct: 1717 HLQI----DDIAKAKTA---LEEQLSRLQREKN--EIQNRLEEDQEDMNELMKKHKAAVA 1767
Query: 215 QEQTVVLQVRP-HSDAKEVQVKVMEAAEELDAWQSGRELCDGQLRGVQYSTESLMEEMAR 273
Q + Q+ + +E + E E+L A QS E + + V S S E R
Sbjct: 1768 QASRDLAQINDLQAQLEEANKEKQELQEKLQALQSQVEFLEQSM--VDKSLVSRQEAKIR 1825
Query: 274 ADRETRL 280
+ ETRL
Sbjct: 1826 -ELETRL 1831
Score = 35.8 bits (81), Expect = 0.061
Identities = 38/169 (22%), Positives = 75/169 (44%), Gaps = 22/169 (13%)
Query: 56 LQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSER--ERSLLRRRSQAAQP--- 110
L+ Q+D + R + RG A +++QDL+ R ++++ + + P
Sbjct: 1180 LEEQRDEQTSRNLTL-FQAACRGYLARQHFKKRKIQDLAIRCVQKNIKKNKGVKDWPWWK 1238
Query: 111 ------------LQGEAREAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQL 158
L E E +++R +LE+AE+ + +L +S +L+ + EL+S+L
Sbjct: 1239 LFTTVRPLIEVQLSEEQIRNKDEEIQQLRSKLEKAEKERNELRLNSDRLESRISELTSEL 1298
Query: 159 FYYGGELQSQKSTEQQLAAQLV-TLQNELELAETKCALQEEKLQQDALQ 206
E + +S Q L A+ L+ E E+ E + K Q + ++
Sbjct: 1299 ---TDERNTGESASQLLDAETAERLRAEKEMKELQTQYDALKKQMEVME 1344
Score = 35.8 bits (81), Expect = 0.061
Identities = 39/168 (23%), Positives = 72/168 (42%), Gaps = 17/168 (10%)
Query: 53 ELLLQLQKDNRDGRQRKQEL----------EKLMRGLEAESESLNQRLQDLSERERSLLR 102
EL +L + G Q L EK M+ L+ + ++L ++++ + E ++
Sbjct: 1293 ELTSELTDERNTGESASQLLDAETAERLRAEKEMKELQTQYDALKKQMEVM---EMEVME 1349
Query: 103 RRSQAAQPLQGEARE--AARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFY 160
R A + GE + A E + R + E + K+ L+Q E ++ QL
Sbjct: 1350 ARLIRAAEINGEVDDDDAGGEWRLKYERAVREVDFTKKRLQQEFEDKLEVEQQNKRQLER 1409
Query: 161 YGGELQSQKSTEQQLAAQLVTLQNEL--ELAETKCALQEEKLQQDALQ 206
G+LQ+ Q+ QL L EL +TK L+ ++++ L+
Sbjct: 1410 RLGDLQADSEESQRALQQLKKKCQRLTAELQDTKLHLEGQQVRNHELE 1457
>gi|194294523 intersectin 2 isoform 3 [Homo sapiens]
Length = 1670
Score = 59.7 bits (143), Expect = 4e-09
Identities = 66/241 (27%), Positives = 111/241 (46%), Gaps = 31/241 (12%)
Query: 52 QELLLQLQKD-NRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQP 110
Q L+ Q Q++ R ++ K+E E+ R L+ + L+ E++R L R+R + +
Sbjct: 383 QALMEQQQREAERKAQKEKEEWERKQRELQEQEWKKQLELEKRLEKQRELERQREEERRK 442
Query: 111 LQGEAREAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYYGGELQSQKS 170
E REAA++ ER RR E R +E L Q +R+ QE+ L+S+ EL++
Sbjct: 443 -DIERREAAKQELERQRRLEWERIRRQELLNQKNRE-QEEIVRLNSKKKNLHLELEALNG 500
Query: 171 TEQQLAAQL-------VTLQNELELAETKCALQ--EEKLQQDALQTAEAWAIFQEQTVVL 221
QQ++ +L T + ELE+ + +C L+ E K Q LQ + Q ++
Sbjct: 501 KHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQQELQ--------EYQNKLI 552
Query: 222 QVRPHSDAKEVQVKVMEAAEELDAWQS--------GRELCD---GQLRGVQYSTESLMEE 270
+ P ++K M+ + D+ S ELC QL ++ T S + E
Sbjct: 553 YLVPEKQLLNERIKNMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQLDALEKETASKLSE 612
Query: 271 M 271
M
Sbjct: 613 M 613
Score = 46.6 bits (109), Expect = 3e-05
Identities = 64/273 (23%), Positives = 122/273 (44%), Gaps = 42/273 (15%)
Query: 16 QPARRSLPPIVTPASRRLGPRGGRHLGSVSTAMAATQELLLQLQKDNRDGRQRKQELEKL 75
QP +LPP + P S R GG+ + S++ + + Q++ Q++ + +K
Sbjct: 316 QPLPLTLPPELVPPSFR----GGKQIDSINGTLPSYQKM----QEEEPQKKLPVTFEDKR 367
Query: 76 MRGLEAESESLNQRLQDLSERERSLLRRRSQAAQP----LQGEAREAARERAERVRRRLE 131
E + L +R Q L E+++ R++Q + Q E +E ++ + +RLE
Sbjct: 368 KANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWERKQRELQEQEWKKQLELEKRLE 427
Query: 132 ---EAERHKE-----DLEQH-------SRQLQEQWEELSSQLFYYGGELQSQKSTEQQ-- 174
E ER +E D+E+ RQ + +WE + Q EL +QK+ EQ+
Sbjct: 428 KQRELERQREEERRKDIERREAAKQELERQRRLEWERIRRQ------ELLNQKNREQEEI 481
Query: 175 --LAAQLVTLQNELELAETKCALQEEKLQQDAL--QTAEAWAIFQEQTVVLQVRPHSDAK 230
L ++ L ELE K +LQ L QT + ++ L++ + K
Sbjct: 482 VRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEI---MEIK 538
Query: 231 EVQVKVMEAAEELDAWQSGRELCDGQLRGVQYS 263
++Q ++ E +L ++L + +++ +Q+S
Sbjct: 539 QLQQELQEYQNKLIYLVPEKQLLNERIKNMQFS 571
Score = 31.2 bits (69), Expect = 1.5
Identities = 33/167 (19%), Positives = 70/167 (41%), Gaps = 6/167 (3%)
Query: 120 RERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYYGGELQSQKSTEQQLAAQL 179
+ +A R +E +R + +EQ R+ + + ++ + ELQ Q+ +Q +
Sbjct: 366 KRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWERKQRELQEQEWKKQLELEKR 425
Query: 180 VTLQNELELAETKCALQEEKLQQDALQTAE-----AWAIFQEQTVVLQV-RPHSDAKEVQ 233
+ Q ELE + ++ + ++ A Q E W + Q ++ Q R + +
Sbjct: 426 LEKQRELERQREEERRKDIERREAAKQELERQRRLEWERIRRQELLNQKNREQEEIVRLN 485
Query: 234 VKVMEAAEELDAWQSGRELCDGQLRGVQYSTESLMEEMARADRETRL 280
K EL+A + G+L+ V+ ++ E+ D++ L
Sbjct: 486 SKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDL 532
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 59.3 bits (142), Expect = 5e-09
Identities = 56/234 (23%), Positives = 109/234 (46%), Gaps = 14/234 (5%)
Query: 50 ATQELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQ 109
A +E+L L+ ++R+ + L++ E E + LQD + +++L+ R Q +
Sbjct: 1884 ALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELE 1943
Query: 110 PLQGEAR------EAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYYGG 163
L+ E++ EAAR RAE ++ L +A + EQH + E L +
Sbjct: 1944 ALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQA 2003
Query: 164 ELQSQKSTEQQLAAQLVTLQNELELAETKCALQEEKLQQDALQTAEAWAIFQEQTVVLQV 223
L + ++ +QL L + E++ + + ++LQQ Q E QE+ +L+
Sbjct: 2004 SLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLE- 2062
Query: 224 RPHSDAKEVQVKVMEAAEELDAWQSGRELCDGQLRGVQYSTESLMEEMARADRE 277
S A+ VQ +++ + L G+E + ++RG+ S L +A+ ++E
Sbjct: 2063 --KSLAQRVQENMIQEKQNL-----GQEREEEEIRGLHQSVRELQLTLAQKEQE 2109
Score = 58.2 bits (139), Expect = 1e-08
Identities = 59/247 (23%), Positives = 107/247 (43%), Gaps = 11/247 (4%)
Query: 52 QELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPL 111
QEL+LQ ++ QR ++ + L LE SL +R ++L+ + + + R + P
Sbjct: 1658 QELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGP- 1716
Query: 112 QGEAREAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYYGGELQSQKST 171
+A R E ++ L + E+ E ++H +LQE ++L QL ++
Sbjct: 1717 ----SKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLL 1772
Query: 172 EQQLAAQLVTLQNELELAETKCALQEEKLQQDALQTAEAWAIFQEQTVVLQVRPHSDAKE 231
Q ++V LQ +L+ A + L+E+ LQ + A A ++ LQ + ++
Sbjct: 1773 LSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQ----QEQQQ 1828
Query: 232 VQVKVMEAAEELDAWQSGRELCDGQLRGVQYSTESLMEEMARADRETRLFGGPRALAIRR 291
Q + E+ DA Q E L+ + E+ R + E + G R +
Sbjct: 1829 AQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEG--RRVQALE 1886
Query: 292 CVLGALQ 298
VLG L+
Sbjct: 1887 EVLGDLR 1893
Score = 52.8 bits (125), Expect = 5e-07
Identities = 59/230 (25%), Positives = 96/230 (41%), Gaps = 38/230 (16%)
Query: 44 VSTAMAATQELLLQLQKDNR-------DGRQRKQELEKLMRGLEAESESLNQRLQDLSER 96
V+ A+A ++ + +L D R +L L L + LNQ+L L E
Sbjct: 566 VTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEE 625
Query: 97 ERSLLRRRSQAAQPLQG---------EAREAARERAERVRRRLEEAERHKEDLEQHSRQL 147
+S+ R A Q + REA E+ + +L++AE +L+ R +
Sbjct: 626 NQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDI 685
Query: 148 QEQWEELSSQLFYYGGELQSQKSTEQQLAAQLVTLQNELELAETKCALQEEKLQQDALQT 207
QE+ EE+ +L +S QQ AA +LE + QEE L + A+Q
Sbjct: 686 QEEKEEIQKKL---------SESRHQQEAA-----TTQLEQLHQEAKRQEEVLAR-AVQE 730
Query: 208 AEAWAIFQEQTVVLQVRPHSDAKEVQVKVMEAAEELDAWQSGRELCDGQL 257
EA + L+VR + ++ Q + AE+L S +EL + L
Sbjct: 731 KEA---LVREKAALEVRLQAVERDRQ----DLAEQLQGLSSAKELLESSL 773
Score = 52.4 bits (124), Expect = 6e-07
Identities = 56/207 (27%), Positives = 94/207 (45%), Gaps = 22/207 (10%)
Query: 52 QELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPL 111
+E +LQ D RD ++ K+E++K + + E+ +L+ L + + ++A Q
Sbjct: 672 EEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEK 731
Query: 112 QGEAREAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYYGGELQSQKS- 170
+ RE A + RL+ ER ++DL + + L E L S LF E Q Q S
Sbjct: 732 EALVREKA-----ALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLF----EAQQQNSV 782
Query: 171 ---TEQQLAAQL--VTLQNELELAETKC---ALQEEKLQQDALQTAEAWAIF---QEQTV 219
T+ QL Q+ VT E+ E +C L E+ Q + + A A + QE
Sbjct: 783 IEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKT 842
Query: 220 VLQVRPHSDAKEVQVKVMEAAEELDAW 246
L+ + + KEV ++ E E+ +W
Sbjct: 843 ALEQQKAAHEKEVN-QLREKWEKERSW 868
Score = 51.6 bits (122), Expect = 1e-06
Identities = 53/236 (22%), Positives = 111/236 (47%), Gaps = 13/236 (5%)
Query: 54 LLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQD----LSERERSL--LRRRSQA 107
+L +K+ ++ EL++L LE + + L++++ + LS+RE+ + L+++ Q
Sbjct: 1730 ILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQE 1789
Query: 108 AQPLQGEAREAA-RERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYYGGELQ 166
A+ QGE +E + + + + +R L + ++ E L+Q +Q Q Q E + + G L+
Sbjct: 1790 ARE-QGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALE 1848
Query: 167 SQKSTEQQLAAQLVTLQNELELAETKCALQEEKLQQDALQTAEAWAIFQEQTVVLQVRPH 226
T ++ +L + + E + A++ ++Q + A +EQ L
Sbjct: 1849 QAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQ 1908
Query: 227 SDAKEVQVKVMEAAEELDAWQSGRELC---DGQLRGVQYSTESL--MEEMARADRE 277
A++ Q +E D+W + + D +L ++ ++S EE ARA E
Sbjct: 1909 QCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAE 1964
Score = 50.1 bits (118), Expect = 3e-06
Identities = 57/199 (28%), Positives = 95/199 (47%), Gaps = 33/199 (16%)
Query: 53 ELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERS-LLRRRSQAAQPL 111
E LLQ QK+ D Q+LE+L + + ++Q L E+E + +L+ + Q AQ
Sbjct: 932 ETLLQTQKELADA---SQQLERLRQDM---------KVQKLKEQETTGILQTQLQEAQR- 978
Query: 112 QGEAREAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYYGGELQSQKST 171
E +EAAR+ + + EE+ L Q LQ+Q E+L SQL + SQ+
Sbjct: 979 --ELKEAARQHRDDLAALQEES----SSLLQDKMDLQKQVEDLKSQLV---AQDDSQRLV 1029
Query: 172 EQQLAAQL------VTLQNELELAETKCALQEEKLQQDALQTAEAWAIFQEQTVVLQVRP 225
EQ++ +L +Q ELE + L + +Q L EA +I Q++ L+
Sbjct: 1030 EQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALR--- 1086
Query: 226 HSDAKEVQVKVMEAAEELD 244
D +E Q + E + +++
Sbjct: 1087 -QDMQEAQGEQKELSAQME 1104
Score = 46.2 bits (108), Expect = 4e-05
Identities = 59/261 (22%), Positives = 119/261 (45%), Gaps = 48/261 (18%)
Query: 49 AATQELLLQLQKDNRDGRQRKQELEKLMRGLEA---ESESLNQRLQDLSERERSLLRRRS 105
AA + L +++D +D ++ Q L LE+ E++ N ++ + ++ +
Sbjct: 739 AALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVT 798
Query: 106 QAAQPLQGEAR------EAARERAERVR----RRLEEAERH-KEDLEQHS-------RQL 147
QA + +QGE R + R +AE+ R R+L +AE+ K LEQ QL
Sbjct: 799 QAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQL 858
Query: 148 QEQWEELSSQLFYYGGELQSQKSTEQQLAAQLVTLQNELELAETKCALQEEKLQQDALQT 207
+E+WE + + +Q+LA L +L E E E + L+E++ + +A+Q
Sbjct: 859 REKWE-------------KERSWHQQELAKALESL--EREKMELEMRLKEQQTEMEAIQA 903
Query: 208 AEAWAIFQEQTVVLQVRPHSDAKEV---------QVKVMEAAEELDAWQSGRELCDGQLR 258
Q ++ + Q++ ++ + V Q ++ +A+++L+ + ++ Q
Sbjct: 904 QREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKV---QKL 960
Query: 259 GVQYSTESLMEEMARADRETR 279
Q +T L ++ A RE +
Sbjct: 961 KEQETTGILQTQLQEAQRELK 981
Score = 43.9 bits (102), Expect = 2e-04
Identities = 60/308 (19%), Positives = 120/308 (38%), Gaps = 73/308 (23%)
Query: 39 RHLGSVSTAMAATQELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRL----QDLS 94
R S++ ++ ++ LL LQ+ + +Q L + M+ + E + L+ ++ Q++
Sbjct: 1052 REKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVK 1111
Query: 95 ERERSLLRRRSQAAQPLQGEAREAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEEL 154
E+E L + +Q + L EA+ +++R L E L+ R + Q E L
Sbjct: 1112 EKEADFLAQEAQLLEEL-----EASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEAL 1166
Query: 155 SSQLFYYGGELQSQKSTEQQLAAQLVTLQNELELA-----ETK----------------- 192
+++ Q + Q AQL +L + L+ A E++
Sbjct: 1167 AAE---------QQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLE 1217
Query: 193 ----------------CALQEE-------KLQQDALQTAEAWAIFQEQTVVLQVR----- 224
AL E KL QD +T + + ++Q L+ R
Sbjct: 1218 PDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTE 1277
Query: 225 -----PHSDAKEVQVKVMEAAEELDAWQSGRELCDGQLRGVQYSTESLMEEMARADRETR 279
H++ +++Q ++ + EE W+ + + +L + + SL + RA+ +
Sbjct: 1278 AEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRM 1337
Query: 280 LFGGPRAL 287
G R L
Sbjct: 1338 EAQGEREL 1345
Score = 43.5 bits (101), Expect = 3e-04
Identities = 50/249 (20%), Positives = 107/249 (42%), Gaps = 19/249 (7%)
Query: 43 SVSTAMAATQELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDL------SER 96
+V++A+ + L + Q+ R + Q+LE+ + EAE ++ LQDL ++
Sbjct: 1240 AVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQE 1299
Query: 97 ERSLLRRRSQAAQPLQGEAREAARERAERVRR---RLEEAERHKEDLEQHSRQLQEQWEE 153
E+S + + + E E R+RR + EA+ +E L+ L Q E
Sbjct: 1300 EKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEH 1359
Query: 154 LSSQLFYYGGELQSQKSTEQQLAAQLVTLQNELELAETKCALQEEKLQ----QDALQTAE 209
L + + E ++Q S L L T ++ L+L + + E+ Q Q L+ A+
Sbjct: 1360 LQAAVV----EARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQ 1415
Query: 210 AWAIFQEQTVVLQ--VRPHSDAKEVQVKVMEAAEELDAWQSGRELCDGQLRGVQYSTESL 267
A+ + ++ Q + + ++ ++ E ++ + ++ EL L+ +
Sbjct: 1416 GKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQ 1475
Query: 268 MEEMARADR 276
E++ ++
Sbjct: 1476 QEQIQELEK 1484
Score = 40.4 bits (93), Expect = 0.002
Identities = 48/224 (21%), Positives = 100/224 (44%), Gaps = 34/224 (15%)
Query: 52 QELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPL 111
+ L + +Q+ + +++++ +L + E + L +L +L ++++ + +R Q Q L
Sbjct: 1490 EHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQV-QDL 1548
Query: 112 QGEA---------REAARERAERVRRRLEEAERHKE-----------DLEQHSRQLQEQW 151
+ + E + E ++ ++E E +E DLE+ S++LQ Q
Sbjct: 1549 KKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQS 1608
Query: 152 EE----------LSSQLFYYGGELQSQKSTEQQLAAQLVTLQNELELAETKCALQEEKLQ 201
+ L+ +L E++SQ+ ++L Q L +LE + + LQ+E++Q
Sbjct: 1609 SQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQ 1668
Query: 202 QDALQTAEAWAIFQE--QTVVLQVRPHSDAKEVQVKVM-EAAEE 242
Q I +E + + L +R Q ++M E AEE
Sbjct: 1669 VLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEE 1712
Score = 40.0 bits (92), Expect = 0.003
Identities = 60/257 (23%), Positives = 108/257 (42%), Gaps = 32/257 (12%)
Query: 41 LGSVSTAMAATQELLLQLQKD--NRDGRQRK--QELEKLMRGLEAE-----SESLNQRLQ 91
L ++++ QE+ + LQ RD Q++ ELE R LE E + L
Sbjct: 2180 LAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRRALEKERLHSPGATSTAELG 2239
Query: 92 DLSERERSLLRRRSQAAQPL-QGEAREAARERAERVRRRLEEAERHKEDLEQHSRQLQEQ 150
E+ L A+P G +++ R+R E +++ + E + L++H+ QL+
Sbjct: 2240 SRGEQGVQLGEVSGVEAEPSPDGMEKQSWRQRLEHLQQAVARLEIDRSRLQRHNVQLRST 2299
Query: 151 WEELSSQLFYYGGELQSQKSTEQQLAAQLVTLQNELELAETKCALQEEKLQQDALQTAEA 210
E++ + + + E AAQ +L E+ A Q++ Q A+
Sbjct: 2300 LEQVERE--------RRKLKREAMRAAQAGSL--EISKATASSPTQQDGRGQKN-SDAKC 2348
Query: 211 WAIFQEQTVVLQVRPHSDAKEVQVKVMEAAEELDAWQSGRELCDGQLRGVQYSTESLMEE 270
A Q++ V+LQ + + K+ Q + +A Q+ REL G+ +S +
Sbjct: 2349 VAELQKEVVLLQAQLTLERKQKQDYITRSA------QTSRELA-----GLHHSLSHSLLA 2397
Query: 271 MARADRETRLFGGPRAL 287
+A+A T L R L
Sbjct: 2398 VAQAPEATVLEAETRRL 2414
Score = 38.5 bits (88), Expect = 0.009
Identities = 70/287 (24%), Positives = 120/287 (41%), Gaps = 64/287 (22%)
Query: 48 MAATQEL--LLQLQKDN--RDGRQRKQELEKLMR----------GLEAESESLNQRLQDL 93
+A QE LLQ Q D +G+ +Q L+KL L+ E +SL++ ++L
Sbjct: 409 LAGCQEAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKE-REL 467
Query: 94 SERERSLLR-------------RRSQAAQPLQGEAREAARE-RAERVRRRLEEAERHKED 139
++ R LR RR LQG++ + +E + E + + E ER +E
Sbjct: 468 LQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEM 527
Query: 140 LEQHSRQLQEQWEEL-----SSQLFYYGGELQSQKSTE--------QQLAAQLVTLQNEL 186
L + E EL + + + GEL Q+ TE +Q A+L + +N L
Sbjct: 528 LMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTL 587
Query: 187 --ELAETKC------------ALQEEKLQQDALQTAEAWAIFQEQTVVLQVRPHSDAKE- 231
E+A+ + AL + L Q LQ E + Q+V ++ A+
Sbjct: 588 KTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEE-----ENQSVCSRMEAAEQARNA 642
Query: 232 VQVKVMEAAEELDA-WQSGRELCDGQLRGVQYSTESLMEEMARADRE 277
+QV + EA + +A W+ L + QL+ + + L ++ E
Sbjct: 643 LQVDLAEAEKRREALWEKNTHL-EAQLQKAEEAGAELQADLRDIQEE 688
Score = 36.2 bits (82), Expect = 0.046
Identities = 54/218 (24%), Positives = 92/218 (42%), Gaps = 37/218 (16%)
Query: 39 RHLGSVSTAMAATQELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLN-------QRLQ 91
+ + + + + A + ++++ ++ + QE ++ + LE E SL QRL
Sbjct: 1010 KQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLL 1069
Query: 92 DLSE------RERSLLRRRSQAAQPLQGEAREAARERAERVRRRLEEAERHKEDLEQHSR 145
L E +E S LR+ Q A QGE +E + A+ R E E+ + L Q ++
Sbjct: 1070 VLQEADSIRQQELSALRQDMQEA---QGEQKELS---AQMELLRQEVKEKEADFLAQEAQ 1123
Query: 146 QLQEQWEELSSQLFYYGGELQSQKSTEQQLAAQLVTLQNELELAETKCALQEEKLQQDAL 205
L+ EL++ TEQQL A L E + A+ + L+ + Q +AL
Sbjct: 1124 LLE---------------ELEASHITEQQLRASL--WAQEAKAAQLQLRLRSTESQLEAL 1166
Query: 206 QTAEAWAIFQEQTVVLQVRPHSDAKEVQVKVMEAAEEL 243
AE Q Q +S ++ V E+ EL
Sbjct: 1167 -AAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPEL 1203
Score = 35.4 bits (80), Expect = 0.079
Identities = 44/173 (25%), Positives = 73/173 (42%), Gaps = 24/173 (13%)
Query: 98 RSLLRRRSQAAQPLQGEAREAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQ 157
RS+L RR QA Q L+ + +E ++++ ++ E + L Q ++L + + L+ Q
Sbjct: 392 RSVLTRRRQAVQDLRQQLA-GCQEAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQ 450
Query: 158 LFYYGGELQSQKSTEQQLAAQLVTLQNELELAETKCALQEEKLQQDALQTAEAWAIFQEQ 217
GE+ S + L L+ +LE+ E EAW + +
Sbjct: 451 TVDLQGEVDSLSKERELLQKAREELRQQLEVLE-----------------QEAWRL-RRV 492
Query: 218 TVVLQVRPHSDAKEVQVKVMEAAEELDAWQSGRELCDGQLRGVQ-YSTESLME 269
V LQ++ S Q + E EEL RE L G++ +ESL E
Sbjct: 493 NVELQLQGDS----AQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSE 541
>gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens]
Length = 1220
Score = 58.9 bits (141), Expect = 7e-09
Identities = 74/289 (25%), Positives = 121/289 (41%), Gaps = 46/289 (15%)
Query: 4 ATLGLPLPPIVIQPARRSLPP-IVTPASRRLGPRGGRH-LGSVSTAMAATQELLLQ---- 57
A G PLPP+ LPP + P+ RR+ G + S S +E +L+
Sbjct: 289 AMSGQPLPPV--------LPPEYIPPSFRRVRSGSGISVISSTSVDQRLPEEPVLEDEQQ 340
Query: 58 -----------------LQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSL 100
++ N + +R+Q L + R + L + Q+ ERER
Sbjct: 341 QLEKKLPVTFEDKKRENFERGNLELEKRRQALLEQQRKEQERLAQLERAEQERKERERQE 400
Query: 101 LRRRSQAAQPLQGE-AREAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLF 159
R+ Q Q E RE R+R E R+ +E E K +LE RQ Q +WE Q
Sbjct: 401 QERKRQLELEKQLEKQRELERQREEERRKEIERREAAKRELE---RQRQLEWERNRRQ-- 455
Query: 160 YYGGELQSQKSTEQQ----LAAQLVTLQNELELAETKCALQEEKLQQDALQTAEAWAIFQ 215
EL +Q++ EQ+ L A+ TL+ ELE K E KLQ + +
Sbjct: 456 ----ELLNQRNKEQEDIVVLKAKKKTLEFELEALNDKKHQLEGKLQDIRCRLTTQRQEIE 511
Query: 216 EQTVVLQVRPHSDAKEVQVKVMEAAEELDAWQSGRELCDGQLRGVQYST 264
++R ++ +Q ++ E+ + L +++ + QL+ VQ ++
Sbjct: 512 STNKSRELR-IAEITHLQQQLQESQQMLGRLIPEKQILNDQLKQVQQNS 559
Score = 46.2 bits (108), Expect = 4e-05
Identities = 48/193 (24%), Positives = 91/193 (47%), Gaps = 16/193 (8%)
Query: 66 RQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPLQGEAREAARERAER 125
+Q+ QE ++++ L E + LN +L+ + + L R S EA+E AR+
Sbjct: 528 QQQLQESQQMLGRLIPEKQILNDQLKQVQQNS---LHRDSLVTLKRALEAKELARQHLRD 584
Query: 126 VRRRLEEAERHK-EDLEQHSRQLQEQWEELSSQLFYYGGELQSQKSTEQQLAAQLVTLQN 184
+E+ R K ++++ + QL+E E + Q +LQ QKS E + Q +
Sbjct: 585 QLDEVEKETRSKLQEIDIFNNQLKELREIHNKQ------QLQKQKSMEAERLKQKEQERK 638
Query: 185 ELELAETKCALQEEKLQQDALQTAEAWAIFQEQTVVLQVRPHSDAKEVQVKVMEAAEELD 244
+EL + Q+E+ Q+ A + + W +Q Q RP +E ++K E+ ++ D
Sbjct: 639 IIELEK-----QKEEAQRRAQERDKQWLEHVQQEDEHQ-RPRKLHEEEKLKREESVKKKD 692
Query: 245 AWQSGRELCDGQL 257
+ G++ +L
Sbjct: 693 GEEKGKQEAQDKL 705
>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
Length = 1721
Score = 58.9 bits (141), Expect = 7e-09
Identities = 74/289 (25%), Positives = 121/289 (41%), Gaps = 46/289 (15%)
Query: 4 ATLGLPLPPIVIQPARRSLPP-IVTPASRRLGPRGGRH-LGSVSTAMAATQELLLQ---- 57
A G PLPP+ LPP + P+ RR+ G + S S +E +L+
Sbjct: 289 AMSGQPLPPV--------LPPEYIPPSFRRVRSGSGISVISSTSVDQRLPEEPVLEDEQQ 340
Query: 58 -----------------LQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSL 100
++ N + +R+Q L + R + L + Q+ ERER
Sbjct: 341 QLEKKLPVTFEDKKRENFERGNLELEKRRQALLEQQRKEQERLAQLERAEQERKERERQE 400
Query: 101 LRRRSQAAQPLQGE-AREAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLF 159
R+ Q Q E RE R+R E R+ +E E K +LE RQ Q +WE Q
Sbjct: 401 QERKRQLELEKQLEKQRELERQREEERRKEIERREAAKRELE---RQRQLEWERNRRQ-- 455
Query: 160 YYGGELQSQKSTEQQ----LAAQLVTLQNELELAETKCALQEEKLQQDALQTAEAWAIFQ 215
EL +Q++ EQ+ L A+ TL+ ELE K E KLQ + +
Sbjct: 456 ----ELLNQRNKEQEDIVVLKAKKKTLEFELEALNDKKHQLEGKLQDIRCRLTTQRQEIE 511
Query: 216 EQTVVLQVRPHSDAKEVQVKVMEAAEELDAWQSGRELCDGQLRGVQYST 264
++R ++ +Q ++ E+ + L +++ + QL+ VQ ++
Sbjct: 512 STNKSRELR-IAEITHLQQQLQESQQMLGRLIPEKQILNDQLKQVQQNS 559
Score = 46.2 bits (108), Expect = 4e-05
Identities = 48/193 (24%), Positives = 91/193 (47%), Gaps = 16/193 (8%)
Query: 66 RQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPLQGEAREAARERAER 125
+Q+ QE ++++ L E + LN +L+ + + L R S EA+E AR+
Sbjct: 528 QQQLQESQQMLGRLIPEKQILNDQLKQVQQNS---LHRDSLVTLKRALEAKELARQHLRD 584
Query: 126 VRRRLEEAERHK-EDLEQHSRQLQEQWEELSSQLFYYGGELQSQKSTEQQLAAQLVTLQN 184
+E+ R K ++++ + QL+E E + Q +LQ QKS E + Q +
Sbjct: 585 QLDEVEKETRSKLQEIDIFNNQLKELREIHNKQ------QLQKQKSMEAERLKQKEQERK 638
Query: 185 ELELAETKCALQEEKLQQDALQTAEAWAIFQEQTVVLQVRPHSDAKEVQVKVMEAAEELD 244
+EL + Q+E+ Q+ A + + W +Q Q RP +E ++K E+ ++ D
Sbjct: 639 IIELEK-----QKEEAQRRAQERDKQWLEHVQQEDEHQ-RPRKLHEEEKLKREESVKKKD 692
Query: 245 AWQSGRELCDGQL 257
+ G++ +L
Sbjct: 693 GEEKGKQEAQDKL 705
>gi|238908495 similar to pleckstrin homology domain protein (5V327)
[Homo sapiens]
Length = 506
Score = 56.6 bits (135), Expect = 3e-08
Identities = 66/246 (26%), Positives = 108/246 (43%), Gaps = 39/246 (15%)
Query: 48 MAATQELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQA 107
M T+EL LQ R++++ELE+L + LEAE + + +Q+L + + R
Sbjct: 171 MEETEELCLQ--------REQREELERLNQVLEAEKQQFEEVVQELRMEQEQIKRELELT 222
Query: 108 AQPLQG--EAREAARERAERVRRRLEEAERHK-------EDLEQHSRQLQEQWEELSSQL 158
A+ L+G + ++ R E +++ LEE K E+ E H + L Q E+
Sbjct: 223 ARCLKGVEQEKKELRHLTESLQQTLEELSIEKKKTLEMLEENENHLQTLANQSEQPPPSG 282
Query: 159 FYYGGELQSQKSTEQQLAAQLVTLQNELELAETKCALQEEK----LQQDALQTAEAWAIF 214
+ Q ++ +Q L +L+ + E E AL+EE+ Q ALQ +
Sbjct: 283 GLHSNLRQIEEKMQQLLEEKLLAEKRMKENEERSRALEEEREFYSSQSQALQNS-----L 337
Query: 215 QEQTVVLQVRPHSDAKEVQVKVMEAAEELDAWQSGRELCDGQLRGVQYSTESLM-----E 269
QE T Q EV+V+ +D + RE +G LR ++ S + E
Sbjct: 338 QELTAEKQQAERELKAEVKVR-------MDLERRLRE-AEGALRSLEQGLNSKVRNKEKE 389
Query: 270 EMARAD 275
E RAD
Sbjct: 390 ERMRAD 395
>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
sapiens]
Length = 570
Score = 56.6 bits (135), Expect = 3e-08
Identities = 48/248 (19%), Positives = 108/248 (43%), Gaps = 20/248 (8%)
Query: 48 MAATQELLLQLQKDNRDGRQRKQELEKLMRGLEA---ESESLNQRLQDLSERERSLLRRR 104
M +E++ + ++ R + E E+ +R LE E E + ++ + E E+ + +
Sbjct: 318 MRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEK 377
Query: 105 SQAAQPLQGEAREAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYYGGE 164
Q + E RE+ E++R + E + +E + + ++ EQ EE+ Q +
Sbjct: 378 RQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQ 437
Query: 165 LQSQKSTEQQLAAQLVTLQNELELAETKCALQEEKLQQDALQTAEAWAIFQEQTVVLQVR 224
+ + E+++ Q ++ + E+ + QEEK+ + + E A QEQ ++ R
Sbjct: 438 EEKIREQEKKIREQEEKIREQEEMMQE----QEEKMGEQEGKMCEQEAKMQEQEEKMR-R 492
Query: 225 PHSDAKEVQVKVMEAAEEL------------DAWQSGRELCDGQLRGVQYSTESLMEEMA 272
+E + K+ E E++ W+ ++C+ + + + + +E
Sbjct: 493 QEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEK 552
Query: 273 RADRETRL 280
++E RL
Sbjct: 553 MREQEVRL 560
Score = 47.4 bits (111), Expect = 2e-05
Identities = 43/196 (21%), Positives = 89/196 (45%), Gaps = 14/196 (7%)
Query: 67 QRKQELEKLM---RGLEAESESLNQRLQDLSER------ERSLLRRRSQAAQPLQGEARE 117
+RK E KL+ + L+AE++ L + LQ +S + E L R +Q + E
Sbjct: 236 KRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEE 295
Query: 118 AARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYYGGELQSQKSTEQQLAA 177
+ER E+++ + E+ +E + + + E+ E++ Q + + + E+++
Sbjct: 296 KIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHE 355
Query: 178 Q-LVTLQNELELAETKCALQEEKLQQDALQTAEAWAIFQEQTVVLQVRPHSDAKEVQVKV 236
Q + Q E E K QE++ +Q+A + I +++ ++R + + Q +
Sbjct: 356 QEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEE---KIREQEEMMQEQEEK 412
Query: 237 MEAAEELDAWQSGREL 252
M EE W+ E+
Sbjct: 413 MGEQEE-KMWEQEEEM 427
Score = 42.7 bits (99), Expect = 5e-04
Identities = 22/146 (15%), Positives = 70/146 (47%), Gaps = 2/146 (1%)
Query: 57 QLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPLQGEAR 116
++Q+ R++++++ + + + + E + ++ + + E+E + + + + Q
Sbjct: 426 EMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCE--QEAKM 483
Query: 117 EAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYYGGELQSQKSTEQQLA 176
+ E+ R ++ E E+ + E+ R+ +E +E +++ ++ Q+ Q+
Sbjct: 484 QEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQE 543
Query: 177 AQLVTLQNELELAETKCALQEEKLQQ 202
++ + ++ E + QEEK+Q+
Sbjct: 544 EKMRRQEEKMREQEVRLRQQEEKMQE 569
Score = 41.6 bits (96), Expect = 0.001
Identities = 32/172 (18%), Positives = 82/172 (47%), Gaps = 10/172 (5%)
Query: 52 QELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPL 111
QE ++Q+ R++++++ + + + E + ++ + + E+E + + +
Sbjct: 298 QEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQE 357
Query: 112 QGEAREAARERAERVR----RRLEEAE--RHKEDLEQHSRQLQEQWEELSSQLFYYGGEL 165
+ +E R+ E++R R+ +EA+ R +E + + +++EQ E + Q G +
Sbjct: 358 KIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQE 417
Query: 166 QSQKSTEQQLAAQLVTLQNELELAETKCALQEEKLQQDALQTAEAWAIFQEQ 217
+ E+++ Q + ++ E K QE+K+++ + E + QEQ
Sbjct: 418 EKMWEQEEEMQEQ----EEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQ 465
Score = 38.5 bits (88), Expect = 0.009
Identities = 31/178 (17%), Positives = 79/178 (44%), Gaps = 18/178 (10%)
Query: 52 QELLLQLQKDNRDGRQRK-----QELEKLMRGLEAESESLNQRLQDLSERERSLLRRRS- 105
QE ++Q Q++ ++ K +E+++ + + E + ++ + + E+E + +
Sbjct: 402 QEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEM 461
Query: 106 -QAAQPLQGEAREAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYYGGE 164
Q + GE E+ +++ + E+ R +E + + ++++EQ E++ Q +
Sbjct: 462 MQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQ 521
Query: 165 LQSQKSTEQQLAAQLVTLQNELELAETKCALQEEKLQQDALQTAEAWAIFQEQTVVLQ 222
+ E+++ Q E K QEEK+++ + E ++Q +Q
Sbjct: 522 EEKMWEQEEKMCEQ-----------EEKMQEQEEKMRRQEEKMREQEVRLRQQEEKMQ 568
>gi|63252896 tropomyosin 1 alpha chain isoform 3 [Homo sapiens]
Length = 284
Score = 56.2 bits (134), Expect = 4e-08
Identities = 61/246 (24%), Positives = 118/246 (47%), Gaps = 31/246 (12%)
Query: 41 LGSVSTAMAATQELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSL 100
L S+ + T++ L + + +D +++ + EK EA+ SLN+R+Q + E
Sbjct: 43 LVSLQKKLKGTEDELDKYSEALKDAQEKLELAEKKATDAEADVASLNRRIQLVEEELDRA 102
Query: 101 LRRRSQAAQPLQGEAREAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFY 160
R + A Q L+ EA +AA +E+ER + +E +++ +E+ E QL
Sbjct: 103 QERLATALQKLE-EAEKAA-----------DESERGMKVIESRAQKDEEKMEIQEIQLKE 150
Query: 161 YGGELQSQKSTEQQLAAQLVTLQNEL-------ELAETKCALQEEKLQ--QDALQTAEAW 211
+ +++A +LV ++++L EL+E KCA EE+L+ + L++ EA
Sbjct: 151 AKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGKCAELEEELKTVTNNLKSLEAQ 210
Query: 212 AIFQEQTVVLQVRPHSDAKEVQVKVMEAAEELDAWQSGRELCDGQLRGVQYSTESLMEEM 271
A Q D E ++KV+ +++L ++ E + + ++ S + L E++
Sbjct: 211 AEKYSQ--------KEDRYEEEIKVL--SDKLKEAETRAEFAERSVTKLEKSIDDLEEKV 260
Query: 272 ARADRE 277
A A E
Sbjct: 261 AHAKEE 266
Score = 35.8 bits (81), Expect = 0.061
Identities = 34/165 (20%), Positives = 84/165 (50%), Gaps = 23/165 (13%)
Query: 84 ESLNQRLQDLSERERSLLRRRSQAAQPLQGEAREAARERAERVRRRLEEAERH----KED 139
+++ +++Q L + + L R QA ++AA +R++++ L ++ +++
Sbjct: 2 DAIKKKMQMLKLDKENALDRAEQAEAD-----KKAAEDRSKQLEDELVSLQKKLKGTEDE 56
Query: 140 LEQHSRQLQEQWEELSSQLFYYGGELQSQKSTEQQLAAQLVTLQNELELAETKCALQEEK 199
L+++S L++ E+L EL +K+T+ + A + +L ++L E + +E+
Sbjct: 57 LDKYSEALKDAQEKL---------ELAEKKATDAE--ADVASLNRRIQLVEEELDRAQER 105
Query: 200 LQQ--DALQTAEAWAIFQEQTV-VLQVRPHSDAKEVQVKVMEAAE 241
L L+ AE A E+ + V++ R D ++++++ ++ E
Sbjct: 106 LATALQKLEEAEKAADESERGMKVIESRAQKDEEKMEIQEIQLKE 150
Score = 35.0 bits (79), Expect = 0.10
Identities = 45/170 (26%), Positives = 71/170 (41%), Gaps = 38/170 (22%)
Query: 124 ERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYYGGELQSQKSTEQQL---AAQLV 180
E R E+AE K+ E S+QL+++ L +L K TE +L + L
Sbjct: 16 ENALDRAEQAEADKKAAEDRSKQLEDELVSLQKKL----------KGTEDELDKYSEALK 65
Query: 181 TLQNELELAETKCA--------------LQEEKLQQDALQTAEAWAIFQEQTVVLQVRPH 226
Q +LELAE K L EE+L + + A A +E
Sbjct: 66 DAQEKLELAEKKATDAEADVASLNRRIQLVEEELDRAQERLATALQKLEE------AEKA 119
Query: 227 SDAKEVQVKVMEAAEELDAWQSGRELCDGQLRGVQYSTESL---MEEMAR 273
+D E +KV+E+ + D + E+ + QL+ ++ E EE+AR
Sbjct: 120 ADESERGMKVIESRAQKD--EEKMEIQEIQLKEAKHIAEDADRKYEEVAR 167
>gi|35038601 spindle assembly abnormal protein 6 [Homo sapiens]
Length = 657
Score = 56.2 bits (134), Expect = 4e-08
Identities = 63/258 (24%), Positives = 121/258 (46%), Gaps = 28/258 (10%)
Query: 48 MAATQELLLQLQKDNRDGRQRKQELEKLMRGLEAESESL-NQRLQDLSERERSLLRRRSQ 106
M + + QL + ++KQEL+KL + + +L N+ Q+L+ + L+ + Q
Sbjct: 168 MQSLDDATKQLDFTRKTLAEKKQELDKLRNEWASHTAALTNKHSQELTNEKEKALQAQVQ 227
Query: 107 AAQPLQGEAREAA---RERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYYGG 163
Q + + ++ ++ +++ RL E E +DL + + EL ++L
Sbjct: 228 YQQQHEQQKKDLEILHQQNIHQLQNRLSELEAANKDLTERKYKGDSTIRELKAKLSGVEE 287
Query: 164 ELQSQKSTEQQLAAQLVTL-------QNELELAETKCALQEEKLQ---QDALQTAEAWAI 213
ELQ K L + TL + + +TK A+ E++++ Q L+T EA+
Sbjct: 288 ELQRTKQEVLSLRRENSTLDVECHEKEKHVNQLQTKVAVLEQEIKDKDQLVLRTKEAFDT 347
Query: 214 FQEQTVVLQVRPHSDAKEVQVKVMEA------AEELDAWQSGRELCDGQLRGVQ-----Y 262
QEQ VVL+ + + +VQ+ +EA AE L A + ++L G L+ +
Sbjct: 348 IQEQKVVLE--ENGEKNQVQLGKLEATIKSLSAELLKANEIIKKL-QGDLKTLMGKLKLK 404
Query: 263 STESLMEEMARADRETRL 280
+T ++ +E A++E +L
Sbjct: 405 NTVTIQQEKLLAEKEEKL 422
Score = 45.1 bits (105), Expect = 1e-04
Identities = 51/235 (21%), Positives = 102/235 (43%), Gaps = 31/235 (13%)
Query: 52 QELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRS------ 105
Q L +L+ N+D +RK + + +R L+A+ + + LQ + SL R S
Sbjct: 251 QNRLSELEAANKDLTERKYKGDSTIRELKAKLSGVEEELQRTKQEVLSLRRENSTLDVEC 310
Query: 106 ----QAAQPLQGEAREAARERAE------RVRRRLEEAERHKEDLEQHSRQLQEQWEELS 155
+ LQ + +E + R + + + K LE++ + Q Q +L
Sbjct: 311 HEKEKHVNQLQTKVAVLEQEIKDKDQLVLRTKEAFDTIQEQKVVLEENGEKNQVQLGKLE 370
Query: 156 SQLFYYGGELQSQKSTEQQLAAQLVTLQNELELAETKCALQEEKL-----------QQDA 204
+ + EL ++L L TL +L+L T +Q+EKL Q++
Sbjct: 371 ATIKSLSAELLKANEIIKKLQGDLKTLMGKLKLKNT-VTIQQEKLLAEKEEKLQKEQKEL 429
Query: 205 LQTAEAWAIFQEQTVVLQVRPHSDAKEVQ--VKVMEAAEELDAWQSGRELCDGQL 257
++ I +++ LQ + + K+++ ++++ E+L W + +EL + QL
Sbjct: 430 QDVGQSLRIKEQEVCKLQEQLEATVKKLEESKQLLKNNEKLITWLN-KELNENQL 483
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 55.8 bits (133), Expect = 6e-08
Identities = 62/262 (23%), Positives = 116/262 (44%), Gaps = 37/262 (14%)
Query: 52 QELLLQLQKDNRDGRQRKQELEKL------MRGLEAESESLNQRLQDLSERERSLLRRRS 105
+E L K + + +QEL+ L R + + E ++ L E+S+ R +
Sbjct: 1409 EEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYA 1468
Query: 106 QAAQPLQGEAREAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYYGGEL 165
+ + EARE +A + R LEEA KE+ E+ ++QL+ E+L S G +
Sbjct: 1469 EERDRAEAEAREK-ETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNV 1527
Query: 166 ----QSQKSTEQQ---LAAQLVTLQNELELAETKCALQEEKLQ------QDALQTAEAWA 212
+S+++ EQQ + QL L++EL+ E E +Q + LQT +
Sbjct: 1528 HELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQN 1587
Query: 213 IFQEQTVVLQVR---------------PHSDAKEVQVKVMEAAEELDAWQSGRELCDGQL 257
+++ ++ QVR + K++++ + + +++A R+ QL
Sbjct: 1588 EEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQL 1647
Query: 258 RGVQYSTESLMEEM--ARADRE 277
R +Q + E+ ARA R+
Sbjct: 1648 RKLQAQMKDYQRELEEARASRD 1669
Score = 48.1 bits (113), Expect = 1e-05
Identities = 46/229 (20%), Positives = 104/229 (45%), Gaps = 13/229 (5%)
Query: 55 LLQLQKDNRDGRQRKQELEKLMRGLEAESE-SLNQRLQDLSERERSLLRRRSQAAQPLQG 113
L +L+ + + K LE M+ ++A+ E L R + E++R L+++ + L+
Sbjct: 1548 LEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELED 1607
Query: 114 EAREAARERAERVRRR--LEEAERHKEDLEQHSRQLQEQWEELSSQLFYYGGELQSQKST 171
E ++ A A + + L++ E E + ++ +Q +L +Q+ Y EL+ +++
Sbjct: 1608 ERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARAS 1667
Query: 172 EQQLAAQLVTLQNELELAETKCALQEEKLQQDALQTAEAWAIFQEQTVVLQVRPHSDAKE 231
++ AQ + +L+ E + +E+L + A A + + ++ + K
Sbjct: 1668 RDEIFAQSKESEKKLKSLEAEILQLQEELASS--ERARRHAEQERDELADEITNSASGKS 1725
Query: 232 --------VQVKVMEAAEELDAWQSGRELCDGQLRGVQYSTESLMEEMA 272
++ ++ + EEL+ QS EL + + R ++L E+A
Sbjct: 1726 ALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELA 1774
Score = 46.2 bits (108), Expect = 4e-05
Identities = 61/278 (21%), Positives = 123/278 (44%), Gaps = 38/278 (13%)
Query: 30 SRRLGPRGGRHLGSVSTAMAATQELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQR 89
+ + G + + S+ + + TQELL Q++ R +K L +R LE E SL ++
Sbjct: 1299 AEKKGIKFAKDAASLESQLQDTQELL---QEETR----QKLNLSSRIRQLEEEKNSLQEQ 1351
Query: 90 LQDLSER----ERSLLRRRSQAAQPLQG------------EAREAARERAERVRRRLEEA 133
++ E E+ +L +SQ A + EA++ + AE + +RLEE
Sbjct: 1352 QEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEK 1411
Query: 134 ERHKEDLEQHSRQLQEQWEELSSQLFY---YGGELQSQKSTEQQLAAQLVTLQ----NEL 186
+ LE+ +LQ++ ++L+ L + L+ ++ QL A+ ++ E
Sbjct: 1412 ALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEER 1471
Query: 187 ELAETKCALQEEK---LQQDALQTAEAWAIFQEQTVVLQVRPHSDAKEVQVKVMEAAEEL 243
+ AE + +E K L + + EA F+ Q L+ +D +++ + + +
Sbjct: 1472 DRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLR----ADMEDLMSSKDDVGKNV 1527
Query: 244 DAWQSGRELCDGQLRGVQYSTESLMEEM-ARADRETRL 280
+ + + Q+ ++ E L +E+ A D + RL
Sbjct: 1528 HELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRL 1565
Score = 45.4 bits (106), Expect = 8e-05
Identities = 49/224 (21%), Positives = 98/224 (43%), Gaps = 19/224 (8%)
Query: 52 QELLLQ-LQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQP 110
QE+++ L++ + + +QELEK R L+ E+ L ++ +L + L + ++ +
Sbjct: 1032 QEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEE 1091
Query: 111 LQGEAREAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYYGGELQSQKS 170
LQG R ++ HK + + R+LQ Q EL + E S+
Sbjct: 1092 LQGALA------------RGDDETLHKNNALKVVRELQAQIAELQED---FESEKASRNK 1136
Query: 171 TEQQ---LAAQLVTLQNELELAETKCALQEEKLQQDALQTAEAWAIFQEQTVVLQVRPHS 227
E+Q L+ +L L+ ELE A Q+E + + AE +E+T + +
Sbjct: 1137 AEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQD 1196
Query: 228 DAKEVQVKVMEAAEELDAWQSGRELCDGQLRGVQYSTESLMEEM 271
+ + E +E+L+ + + + +G++ + L E+
Sbjct: 1197 MRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEV 1240
Score = 44.3 bits (103), Expect = 2e-04
Identities = 52/249 (20%), Positives = 108/249 (43%), Gaps = 11/249 (4%)
Query: 29 ASRRLGPRGGRHLGSVSTAMAATQELLLQLQKDNRDGR-QRKQELEKLMRGLEAESESLN 87
ASR + R L A+ E L ++ R +R+QE+ +L + LE E+++
Sbjct: 1132 ASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHE 1191
Query: 88 QRLQDLSERERSLLRRRSQAAQPLQGEAREAARERAERVRRRLE----EAERHKEDLEQH 143
++QD+ +R + L S+ Q E + + E+ ++ LE E + L+Q
Sbjct: 1192 AQIQDMRQRHATALEELSE-----QLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQV 1246
Query: 144 SRQLQEQWEELSSQLFYYGGELQSQKSTEQQLAAQLVTLQNELELAETKCALQEEKLQQD 203
+ + + ++L +Q+ ++ +LA + LQNEL+ T E+K +
Sbjct: 1247 KAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKF 1306
Query: 204 ALQTAEAWAIFQEQTVVLQVRPHSDAKEVQVKVMEAAEELDAWQSGRELCDGQLRGVQYS 263
A A + Q+ +LQ + ++ + EE ++ Q +E + + ++
Sbjct: 1307 AKDAASLESQLQDTQELLQEETRQKL-NLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQ 1365
Query: 264 TESLMEEMA 272
+L ++A
Sbjct: 1366 VLALQSQLA 1374
Score = 43.5 bits (101), Expect = 3e-04
Identities = 32/132 (24%), Positives = 63/132 (47%), Gaps = 10/132 (7%)
Query: 66 RQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLR--------RRSQAAQPLQGEARE 117
R Q+ + + LE +++ L +LQ+L +S + + Q + L+ EA+E
Sbjct: 1777 RSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKE 1836
Query: 118 --AARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYYGGELQSQKSTEQQL 175
AA + R ++L+E ED +H+ Q +EQ E+ ++++ +L+ + +
Sbjct: 1837 RAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRA 1896
Query: 176 AAQLVTLQNELE 187
A LQ EL+
Sbjct: 1897 NASRRKLQRELD 1908
Score = 43.1 bits (100), Expect = 4e-04
Identities = 41/184 (22%), Positives = 76/184 (41%), Gaps = 25/184 (13%)
Query: 40 HLGSVSTAMAATQELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQ---DLSER 96
H + + Q + +LQ+D + + + EK R L E E+L L+ D +
Sbjct: 1105 HKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAA 1164
Query: 97 ERSLLRRRSQAAQPLQGEAREAARER--------------AERVRRRLEEAERHKEDLEQ 142
++ L +R Q L+ E + E + +LE+A+R K +LE+
Sbjct: 1165 QQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEK 1224
Query: 143 HSRQLQEQWEELSSQLFYYGGELQSQKSTEQQLAAQLVTLQNE--------LELAETKCA 194
+ + L+ +EL+ ++ + ++L AQ+ L + +ELAE
Sbjct: 1225 NKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASK 1284
Query: 195 LQEE 198
LQ E
Sbjct: 1285 LQNE 1288
Score = 41.2 bits (95), Expect = 0.001
Identities = 52/200 (26%), Positives = 89/200 (44%), Gaps = 18/200 (9%)
Query: 50 ATQELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLN---QRLQDLSERERSLLRRRSQ 106
A +EL QL++ R K LEK +GLE +++ L + LQ + ++
Sbjct: 1204 ALEELSEQLEQAKRF----KANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDA 1259
Query: 107 AAQPLQGEAREAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYYGGELQ 166
Q L + E R R E E+A + + +L+ S L+E E+ + L+
Sbjct: 1260 QVQELHAKVSEGDRLRVELA----EKASKLQNELDNVSTLLEEA-EKKGIKFAKDAASLE 1314
Query: 167 SQKSTEQQLAAQLVTLQNELELAETKCALQEEK--LQQDALQTAEAWAIFQEQTVVLQVR 224
SQ Q+L + + +L L+ L+EEK LQ+ + EA ++Q + LQ +
Sbjct: 1315 SQLQDTQELLQE--ETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQ 1372
Query: 225 PHSDAKEV--QVKVMEAAEE 242
K+V + +E+ EE
Sbjct: 1373 LADTKKKVDDDLGTIESLEE 1392
Score = 40.0 bits (92), Expect = 0.003
Identities = 55/265 (20%), Positives = 106/265 (40%), Gaps = 46/265 (17%)
Query: 48 MAATQELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQA 107
+ A EL + ++ +KQELE+++ LE+ E +R Q L ++ +
Sbjct: 896 LQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDL 955
Query: 108 AQPLQGEAREAARER-------AERVRRRLEE----AERHKEDLEQHSRQLQEQWEELSS 156
+ L E E AR++ AE +++EE E + + ++++ E SS
Sbjct: 956 EEQLDEE--EGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSS 1013
Query: 157 QLFY---------------------YGGELQSQKSTEQQLAAQLVTLQNEL-----ELAE 190
QL L+ ++ T Q+L L E ++AE
Sbjct: 1014 QLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAE 1073
Query: 191 TKCALQEEKLQ----QDALQTAEAWAIFQEQTVVLQVRPHSDAKEVQVKVMEAAEELDAW 246
+ + E KLQ ++ LQ A A + + + +E+Q ++ E E+ ++
Sbjct: 1074 LQAQIDELKLQLAKKEEELQGALARG---DDETLHKNNALKVVRELQAQIAELQEDFESE 1130
Query: 247 QSGRELCDGQLRGVQYSTESLMEEM 271
++ R + Q R + E+L E+
Sbjct: 1131 KASRNKAEKQKRDLSEELEALKTEL 1155
Score = 38.5 bits (88), Expect = 0.009
Identities = 49/230 (21%), Positives = 105/230 (45%), Gaps = 28/230 (12%)
Query: 55 LLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPLQGE 114
LLQ+ + + + + +EL K+ + + + L+++ + + LL ++ A+ LQ E
Sbjct: 844 LLQVTRQEEELQAKDEELLKV----KEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAE 899
Query: 115 AREAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYYGGELQSQKSTEQQ 174
A EAE + L ++L+E +L S++ Q ++ +++
Sbjct: 900 TELFA------------EAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKK 947
Query: 175 LAAQLVTLQNELELAE-TKCALQEEKLQQDALQTAEAWAIFQEQTVVLQVRPHS----DA 229
+ A + L+ +L+ E + LQ EK+ TAEA E+ ++L +S +
Sbjct: 948 MQAHIQDLEEQLDEEEGARQKLQLEKV------TAEAKIKKMEEEILLLEDQNSKFIKEK 1001
Query: 230 KEVQVKVMEAAEELDAWQSGRELCDGQLRGVQYSTESLMEEMARADRETR 279
K ++ ++ E + +L A + + ++R Q S +EE + + +TR
Sbjct: 1002 KLMEDRIAECSSQL-AEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTR 1050
>gi|223555975 tropomyosin 4 isoform 1 [Homo sapiens]
Length = 284
Score = 55.1 bits (131), Expect = 1e-07
Identities = 57/221 (25%), Positives = 102/221 (46%), Gaps = 30/221 (13%)
Query: 48 MAATQELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQA 107
+ T++ L + +D +D +++ + EK E + +LN+R+Q + E R + A
Sbjct: 50 LKGTEDELDKYSEDLKDAQEKLELTEKKASDAEGDVAALNRRIQLVEEELDRAQERLATA 109
Query: 108 AQPLQGEAREAARERAERVRRRLEEAERHKEDLEQHSRQLQE----------QWEELSSQ 157
Q L+ EA +AA E ++ A + +E +E QL+E ++EE++ +
Sbjct: 110 LQKLE-EAEKAADESERGMKVIENRAMKDEEKMEIQEMQLKEAKHIAEEADRKYEEVARK 168
Query: 158 LFYYGGELQSQKSTEQ-------QLAAQLVTLQN---ELELAETKCALQEEKLQQ----- 202
L GEL+ + + L +L + N LE A K + +E+K ++
Sbjct: 169 LVILEGELERAEERAEVSELKCGDLEEELKNVTNNLKSLEAASEKYSEKEDKYEEEIKLL 228
Query: 203 -DALQTAEAWAIFQEQTVVLQVRPHSDAKEVQVKVMEAAEE 242
D L+ AE A F E+TV + D +E K+ +A EE
Sbjct: 229 SDKLKEAETRAEFAERTVAKLEKTIDDLEE---KLAQAKEE 266
Score = 45.4 bits (106), Expect = 8e-05
Identities = 51/240 (21%), Positives = 107/240 (44%), Gaps = 38/240 (15%)
Query: 66 RQRKQELEKLMRGLEAESESLNQRLQDLSERERSL----------------LRRRSQAAQ 109
+Q ++EL L + L+ + L++ +DL + + L L RR Q +
Sbjct: 37 KQVEEELTHLQKKLKGTEDELDKYSEDLKDAQEKLELTEKKASDAEGDVAALNRRIQLVE 96
Query: 110 PLQGEARE---AARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYYGGELQ 166
A+E A ++ E + +E+ER + +E + + +E+ E QL +
Sbjct: 97 EELDRAQERLATALQKLEEAEKAADESERGMKVIENRAMKDEEKMEIQEMQLKEAKHIAE 156
Query: 167 SQKSTEQQLAAQLVTLQNEL-------ELAETKCALQEEKLQQ--DALQTAEAWAIFQEQ 217
+++A +LV L+ EL E++E KC EE+L+ + L++ EA
Sbjct: 157 EADRKYEEVARKLVILEGELERAEERAEVSELKCGDLEEELKNVTNNLKSLEA------- 209
Query: 218 TVVLQVRPHSDAKEVQVKVMEAAEELDAWQSGRELCDGQLRGVQYSTESLMEEMARADRE 277
+ D E ++K++ +++L ++ E + + ++ + + L E++A+A E
Sbjct: 210 -ASEKYSEKEDKYEEEIKLL--SDKLKEAETRAEFAERTVAKLEKTIDDLEEKLAQAKEE 266
Score = 34.3 bits (77), Expect = 0.18
Identities = 31/167 (18%), Positives = 82/167 (49%), Gaps = 27/167 (16%)
Query: 84 ESLNQRLQDLSERERSLLRRRSQAAQPLQGEAREAARERAERVRRRLEEAERH----KED 139
E++ +++Q L + + + R QA ++AA ++ ++V L ++ +++
Sbjct: 2 EAIKKKMQMLKLDKENAIDRAEQAEAD-----KKAAEDKCKQVEEELTHLQKKLKGTEDE 56
Query: 140 LEQHSRQLQEQWEELSSQLFYYGGELQSQKSTEQQ-----LAAQLVTLQNELELAETKCA 194
L+++S L++ E+L EL +K+++ + L ++ ++ EL+ A+ + A
Sbjct: 57 LDKYSEDLKDAQEKL---------ELTEKKASDAEGDVAALNRRIQLVEEELDRAQERLA 107
Query: 195 LQEEKLQQDALQTAEAWAIFQEQTVVLQVRPHSDAKEVQVKVMEAAE 241
+KL++ E+ + V++ R D ++++++ M+ E
Sbjct: 108 TALQKLEEAEKAADES----ERGMKVIENRAMKDEEKMEIQEMQLKE 150
>gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]
Length = 2003
Score = 55.1 bits (131), Expect = 1e-07
Identities = 70/291 (24%), Positives = 119/291 (40%), Gaps = 50/291 (17%)
Query: 48 MAATQELLLQLQKDNRDGRQ----RKQELEKLMRGLEAESESLNQRLQDLSERERSLLRR 103
M A + L + ++ R R+ + +E EK ++GLEAE L + L R +
Sbjct: 1675 MQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQD 1734
Query: 104 RSQAAQPLQGE--AREAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYY 161
R + A + ++ A E ++ RL + E E+ + +S L +++ +L Q+
Sbjct: 1735 RDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESL 1794
Query: 162 GGELQSQKSTE-------QQLAAQLVTLQNEL---------------ELAETKCALQEEK 199
EL +++S QQL Q+ L+ L E+K A EE+
Sbjct: 1795 TTELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQ 1854
Query: 200 LQQDA---------LQTAE------AWAIFQEQTVVLQVRPHSDAKEVQVKVM-----EA 239
L+Q+ ++ AE + +E+ V Q+R + ++VK + EA
Sbjct: 1855 LEQETRERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEA 1914
Query: 240 AEELDAWQSGRELCDGQLRGVQYSTESLMEEMARADRETRLFGGPRALAIR 290
EE Q+GR +L V S ES+ E+ RL GP R
Sbjct: 1915 EEEASRAQAGRRRLQRELEDVTESAESMNREVTTL--RNRLRRGPLTFTTR 1963
Score = 53.9 bits (128), Expect = 2e-07
Identities = 69/259 (26%), Positives = 116/259 (44%), Gaps = 30/259 (11%)
Query: 63 RDGRQRKQELEKLMRGLEAESESLNQRL---QDLSERERSLLRRRSQAAQPLQGEAREAA 119
R + +QELEKL R L+ ES L +++ Q +E R+ L R+ + Q A +
Sbjct: 1069 RKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEG 1128
Query: 120 RERAERVRRRLEEAE----RHKEDLEQH---SRQLQEQWEELSSQLFYYGGELQSQKSTE 172
RA+ + + L EA+ +EDLE + ++Q +L +L GEL+ + +
Sbjct: 1129 GARAQ-LLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELED--TLD 1185
Query: 173 QQLAAQLVTLQNELELAETKCALQEEKLQQDA----LQTAEAWAIFQEQTVVLQVRPHSD 228
A Q + + E E+ E K L+EE +A L+ A+ + + Q R
Sbjct: 1186 STNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKG 1245
Query: 229 AKE-----VQVKVMEAAEELDAWQSGRELCDGQLRGVQYSTESLM-----EEMARADRET 278
A E ++ +V E EL + Q+ R+ + + R ++ + + E ARA+
Sbjct: 1246 AWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAE 1305
Query: 279 RLFGGPRALAIRRCVLGAL 297
+L RA A V GAL
Sbjct: 1306 KL---QRAQAELENVSGAL 1321
Score = 52.4 bits (124), Expect = 6e-07
Identities = 63/263 (23%), Positives = 108/263 (41%), Gaps = 31/263 (11%)
Query: 49 AATQEL-------LLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDL--SERERS 99
AA QEL L +L + R+ K EK LEAE L L L + +E
Sbjct: 1217 AAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGE 1276
Query: 100 LLRRRSQ-AAQPLQGEAREAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQL 158
RRR + Q +QG A + R RAE +L+ A+ E++ + + + LS +L
Sbjct: 1277 QRRRRLELQLQEVQGRAGDGERARAE-AAEKLQRAQAELENVSGALNEAESKTIRLSKEL 1335
Query: 159 FYYGGELQSQKSTEQQLAAQLVTLQNELELAETKCALQEEKLQQDA---------LQTAE 209
+L + Q+ + L + + E + A E+L+++A LQTA+
Sbjct: 1336 SSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQ 1395
Query: 210 A----WAIFQEQTV-------VLQVRPHSDAKEVQVKVMEAAEELDAWQSGRELCDGQLR 258
A W QE+ + R +A+ + ++ E E +D + GR +L
Sbjct: 1396 AQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELD 1455
Query: 259 GVQYSTESLMEEMARADRETRLF 281
E + ++ +++ R F
Sbjct: 1456 DATMDLEQQRQLVSTLEKKQRKF 1478
Score = 49.3 bits (116), Expect = 5e-06
Identities = 57/234 (24%), Positives = 102/234 (43%), Gaps = 25/234 (10%)
Query: 56 LQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRR---RSQAAQPLQ 112
L L + + ++ ++ELE+ R L AE E+L D+ + L R QAA L+
Sbjct: 1511 LSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLR 1570
Query: 113 GEAREAARE--RAERVRRRLEEA-----ERHKEDLEQHSRQLQEQWEELSSQLFYYGGEL 165
+ E E AE + RLE +H+ DL+ +E+ +L+ QL +
Sbjct: 1571 AQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQL----RDA 1626
Query: 166 QSQKSTEQQLAAQLVTLQNELELAETKCALQEEKLQQDALQTAEAWAIFQEQTVVLQVRP 225
+ ++ E++ V + +LE L+E K Q + + A+ Q + + Q+
Sbjct: 1627 EVERDEERKQRTLAVAARKKLE-----GELEELKAQMASAGQGKEEAVKQLRKMQAQM-- 1679
Query: 226 HSDAKEVQVKVMEAAEELDAWQSGRELCDGQLRGVQYSTESLMEEMARADRETR 279
KE+ +V E + S + +L+G++ L EE+A +DR R
Sbjct: 1680 ----KELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARR 1729
Score = 47.8 bits (112), Expect = 2e-05
Identities = 56/241 (23%), Positives = 108/241 (44%), Gaps = 45/241 (18%)
Query: 44 VSTAMAATQELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQD-LSERERS--- 99
+S +++T+ L Q+ ++ + K L +R +EAE+ L ++L++ + RER+
Sbjct: 1331 LSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRE 1390
Query: 100 ----------LLRRRSQAAQPLQG--EAREAARERAERVRRRLEEAERHKEDLEQHSRQL 147
RR+ + A L+ EAR A AE + +RL E + LE+ R+L
Sbjct: 1391 LQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRL 1450
Query: 148 QEQWEELSSQLFYYGGELQSQKSTEQQLAAQLVTLQNELELAETKCALQEEKLQQDALQT 207
Q++ ++ + L EQQ QLV+ L++++ + D L
Sbjct: 1451 QQELDDATMDL-------------EQQ--RQLVS------------TLEKKQRKFDQLLA 1483
Query: 208 AEAWAIFQEQTVVLQVRPHSDAKEVQVKVMEAAEELDAWQSGRELCDGQLRGVQYSTESL 267
E A+ + V + R ++ +E + + + L+ Q RE + Q R ++ E+L
Sbjct: 1484 EEKAAVL--RAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEAL 1541
Query: 268 M 268
+
Sbjct: 1542 L 1542
Score = 46.6 bits (109), Expect = 3e-05
Identities = 62/253 (24%), Positives = 109/253 (43%), Gaps = 26/253 (10%)
Query: 36 RGGRHLGSVSTAMAATQELLLQLQKDNRDGRQR-KQELEKLMRGLEAES------ESLNQ 88
R R +++ +A E + +L++ GR+R +QEL+ LE + E +
Sbjct: 1421 RAAREAEALTQRLAEKTETVDRLER----GRRRLQQELDDATMDLEQQRQLVSTLEKKQR 1476
Query: 89 RLQDLSERERSLLRRRSQAAQPLQGEAREAARERAERVRRRLEEAERHKEDLEQHSRQLQ 148
+ L E++ + R + + + E RE RA + R LEE + +E+LE+ +R L+
Sbjct: 1477 KFDQLLAEEKAAVLRAVEERERAEAEGRER-EARALSLTRALEEEQEAREELERQNRALR 1535
Query: 149 EQWEELSSQLFYYGGELQS-------QKSTEQQLAAQLVTLQNELELAETKCALQEEKLQ 201
+ E L S G + + L AQ+ L++EL AE E +Q
Sbjct: 1536 AELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQ 1595
Query: 202 QDALQTAEAWAIFQEQTVVLQVRPHSDAKEVQVKVMEAAEELDAWQSGRELCDGQLRGVQ 261
AL+T + Q + + R AK+++ +A E D + R L + ++
Sbjct: 1596 --ALKTQHERDL-QGRDEAGEERRRQLAKQLR----DAEVERDEERKQRTLAVAARKKLE 1648
Query: 262 YSTESLMEEMARA 274
E L +MA A
Sbjct: 1649 GELEELKAQMASA 1661
Score = 45.4 bits (106), Expect = 8e-05
Identities = 55/225 (24%), Positives = 98/225 (43%), Gaps = 27/225 (12%)
Query: 52 QELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPL 111
QEL L+ + +G ++K +LEK+ EA+ + + L L ++ L + R L
Sbjct: 978 QELEAHLEAE--EGARQKLQLEKVTT--EAKMKKFEEDLLLLEDQNSKLSKERKLLEDRL 1033
Query: 112 QGEAREAARERAE-----RVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYYGGELQ 166
+ +AA E + ++R + E ED + + +++ E+L +L ELQ
Sbjct: 1034 AEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQ 1093
Query: 167 SQKSTEQQLAAQLVTLQNELELAETKCALQEEKLQQDALQTAEAWAIFQEQTVVLQVRPH 226
Q +QQ A +L + +EE+LQ AL AE + Q +
Sbjct: 1094 EQMVEQQQRAEEL----------RAQLGRKEEELQA-ALARAEDEGGARAQLL------- 1135
Query: 227 SDAKEVQVKVMEAAEELDAWQSGRELCDGQLRGVQYSTESLMEEM 271
+E Q + EA E+L++ + R + Q R + E+L E+
Sbjct: 1136 KSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGEL 1180
Score = 42.7 bits (99), Expect = 5e-04
Identities = 67/257 (26%), Positives = 120/257 (46%), Gaps = 55/257 (21%)
Query: 48 MAATQELLLQLQKDNRDGRQRKQELEKLMRGLEA---ESESLNQRLQDLSERERSLLRRR 104
+ A EL + ++ RKQELE ++ LEA E E ++++Q +E+ +R
Sbjct: 921 LRAEAELCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQ--TEK-----KRL 973
Query: 105 SQAAQPLQG--EAREAARERAERVRRRLE-EAERHKED---LEQHSRQLQEQWEELSSQL 158
Q Q L+ EA E AR++ + + E + ++ +ED LE + +L ++ + L +L
Sbjct: 974 QQHIQELEAHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRL 1033
Query: 159 FYYGGELQSQKSTEQQLAAQL--VTLQNELELAETKCALQEEKLQQDALQTAEAWAIFQE 216
E SQ + E++ L + L+ E +A+ + L++E+ + L+
Sbjct: 1034 ----AEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEK--------- 1080
Query: 217 QTVVLQVRPHSDAKEVQVKVME---AAEELDAWQSGRELCDGQLRGVQYSTESLMEEMAR 273
L+ R ++ E+Q +++E AEEL A Q GR+ E L +AR
Sbjct: 1081 ----LKRRLDGESSELQEQMVEQQQRAEELRA-QLGRK------------EEELQAALAR 1123
Query: 274 ADRETRLFGGPRALAIR 290
A+ E GG RA ++
Sbjct: 1124 AEDE----GGARAQLLK 1136
Score = 42.7 bits (99), Expect = 5e-04
Identities = 54/232 (23%), Positives = 89/232 (38%), Gaps = 28/232 (12%)
Query: 47 AMAATQELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQ 106
++ Q L + Q+D R + + EK R L E E+L L+D + +
Sbjct: 1137 SLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNA------- 1189
Query: 107 AAQPLQGEAREAARERAERVRRRLEEAERHKEDLEQHSRQLQEQ-WEELSSQLFYYGGEL 165
Q E R + +++ LEE R E Q RQ Q EL+ QL
Sbjct: 1190 -----QQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGK 1244
Query: 166 QSQKSTEQQLAAQLVTLQNELELAETKCALQEEKLQQDALQTAEAWAIFQEQTVVLQVRP 225
+ + T L A++ L+ EL +T E++ ++ LQ E
Sbjct: 1245 GAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEV--------------- 1289
Query: 226 HSDAKEVQVKVMEAAEELDAWQSGRELCDGQLRGVQYSTESLMEEMARADRE 277
A + + EAAE+L Q+ E G L + T L +E++ + +
Sbjct: 1290 QGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQ 1341
Score = 37.4 bits (85), Expect = 0.021
Identities = 35/153 (22%), Positives = 67/153 (43%), Gaps = 5/153 (3%)
Query: 82 ESESLNQRLQDLSERERSLLRRRSQAAQPLQGEAREAARERAERVRRRLEEAERHKEDLE 141
+ E L R Q+L ++ + L ++ ++ LQG + ERA + EAE E E
Sbjct: 875 QDEVLQARAQEL-QKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEAEE 933
Query: 142 QHSRQLQEQWEELSSQLFYYGGELQSQKSTEQQLAAQLVTLQNELELAETKCALQE---E 198
R L + +EL + + ++ +Q+ + LQ ++ E +E +
Sbjct: 934 TRGR-LAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGARQ 992
Query: 199 KLQQDALQTAEAWAIFQEQTVVLQVRPHSDAKE 231
KLQ + + T F+E ++L+ + +KE
Sbjct: 993 KLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKE 1025
Score = 32.7 bits (73), Expect = 0.51
Identities = 40/172 (23%), Positives = 80/172 (46%), Gaps = 15/172 (8%)
Query: 112 QGEAREAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYYGGELQSQKST 171
Q E +A + ++V+ +++ R +L+ QL+E+ L+ QL + T
Sbjct: 875 QDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEAEET 934
Query: 172 EQQLAA---QLVTLQNELEL---AETKCALQ---EEKLQQDALQTAEAWAIFQE---QTV 219
+LAA +L + +ELE E +C+ Q E+K Q +Q EA +E Q +
Sbjct: 935 RGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGARQKL 994
Query: 220 VLQ-VRPHSDAKEVQVKVMEAAEELDAWQSGRELCDGQLRGVQYSTESLMEE 270
L+ V + K+ + ++ ++ R+L + +L ++S+++ EE
Sbjct: 995 QLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRL--AEFSSQAAEEE 1044
>gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]
Length = 1995
Score = 55.1 bits (131), Expect = 1e-07
Identities = 70/291 (24%), Positives = 119/291 (40%), Gaps = 50/291 (17%)
Query: 48 MAATQELLLQLQKDNRDGRQ----RKQELEKLMRGLEAESESLNQRLQDLSERERSLLRR 103
M A + L + ++ R R+ + +E EK ++GLEAE L + L R +
Sbjct: 1667 MQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQD 1726
Query: 104 RSQAAQPLQGE--AREAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYY 161
R + A + ++ A E ++ RL + E E+ + +S L +++ +L Q+
Sbjct: 1727 RDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESL 1786
Query: 162 GGELQSQKSTE-------QQLAAQLVTLQNEL---------------ELAETKCALQEEK 199
EL +++S QQL Q+ L+ L E+K A EE+
Sbjct: 1787 TTELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQ 1846
Query: 200 LQQDA---------LQTAE------AWAIFQEQTVVLQVRPHSDAKEVQVKVM-----EA 239
L+Q+ ++ AE + +E+ V Q+R + ++VK + EA
Sbjct: 1847 LEQETRERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEA 1906
Query: 240 AEELDAWQSGRELCDGQLRGVQYSTESLMEEMARADRETRLFGGPRALAIR 290
EE Q+GR +L V S ES+ E+ RL GP R
Sbjct: 1907 EEEASRAQAGRRRLQRELEDVTESAESMNREVTTL--RNRLRRGPLTFTTR 1955
Score = 53.9 bits (128), Expect = 2e-07
Identities = 69/259 (26%), Positives = 116/259 (44%), Gaps = 30/259 (11%)
Query: 63 RDGRQRKQELEKLMRGLEAESESLNQRL---QDLSERERSLLRRRSQAAQPLQGEAREAA 119
R + +QELEKL R L+ ES L +++ Q +E R+ L R+ + Q A +
Sbjct: 1061 RKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEG 1120
Query: 120 RERAERVRRRLEEAE----RHKEDLEQH---SRQLQEQWEELSSQLFYYGGELQSQKSTE 172
RA+ + + L EA+ +EDLE + ++Q +L +L GEL+ + +
Sbjct: 1121 GARAQ-LLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELED--TLD 1177
Query: 173 QQLAAQLVTLQNELELAETKCALQEEKLQQDA----LQTAEAWAIFQEQTVVLQVRPHSD 228
A Q + + E E+ E K L+EE +A L+ A+ + + Q R
Sbjct: 1178 STNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKG 1237
Query: 229 AKE-----VQVKVMEAAEELDAWQSGRELCDGQLRGVQYSTESLM-----EEMARADRET 278
A E ++ +V E EL + Q+ R+ + + R ++ + + E ARA+
Sbjct: 1238 AWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAE 1297
Query: 279 RLFGGPRALAIRRCVLGAL 297
+L RA A V GAL
Sbjct: 1298 KL---QRAQAELENVSGAL 1313
Score = 52.4 bits (124), Expect = 6e-07
Identities = 63/263 (23%), Positives = 108/263 (41%), Gaps = 31/263 (11%)
Query: 49 AATQEL-------LLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDL--SERERS 99
AA QEL L +L + R+ K EK LEAE L L L + +E
Sbjct: 1209 AAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGE 1268
Query: 100 LLRRRSQ-AAQPLQGEAREAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQL 158
RRR + Q +QG A + R RAE +L+ A+ E++ + + + LS +L
Sbjct: 1269 QRRRRLELQLQEVQGRAGDGERARAE-AAEKLQRAQAELENVSGALNEAESKTIRLSKEL 1327
Query: 159 FYYGGELQSQKSTEQQLAAQLVTLQNELELAETKCALQEEKLQQDA---------LQTAE 209
+L + Q+ + L + + E + A E+L+++A LQTA+
Sbjct: 1328 SSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQ 1387
Query: 210 A----WAIFQEQTV-------VLQVRPHSDAKEVQVKVMEAAEELDAWQSGRELCDGQLR 258
A W QE+ + R +A+ + ++ E E +D + GR +L
Sbjct: 1388 AQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELD 1447
Query: 259 GVQYSTESLMEEMARADRETRLF 281
E + ++ +++ R F
Sbjct: 1448 DATMDLEQQRQLVSTLEKKQRKF 1470
Score = 49.3 bits (116), Expect = 5e-06
Identities = 57/234 (24%), Positives = 102/234 (43%), Gaps = 25/234 (10%)
Query: 56 LQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRR---RSQAAQPLQ 112
L L + + ++ ++ELE+ R L AE E+L D+ + L R QAA L+
Sbjct: 1503 LSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLR 1562
Query: 113 GEAREAARE--RAERVRRRLEEA-----ERHKEDLEQHSRQLQEQWEELSSQLFYYGGEL 165
+ E E AE + RLE +H+ DL+ +E+ +L+ QL +
Sbjct: 1563 AQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQL----RDA 1618
Query: 166 QSQKSTEQQLAAQLVTLQNELELAETKCALQEEKLQQDALQTAEAWAIFQEQTVVLQVRP 225
+ ++ E++ V + +LE L+E K Q + + A+ Q + + Q+
Sbjct: 1619 EVERDEERKQRTLAVAARKKLE-----GELEELKAQMASAGQGKEEAVKQLRKMQAQM-- 1671
Query: 226 HSDAKEVQVKVMEAAEELDAWQSGRELCDGQLRGVQYSTESLMEEMARADRETR 279
KE+ +V E + S + +L+G++ L EE+A +DR R
Sbjct: 1672 ----KELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARR 1721
Score = 47.8 bits (112), Expect = 2e-05
Identities = 56/241 (23%), Positives = 108/241 (44%), Gaps = 45/241 (18%)
Query: 44 VSTAMAATQELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQD-LSERERS--- 99
+S +++T+ L Q+ ++ + K L +R +EAE+ L ++L++ + RER+
Sbjct: 1323 LSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRE 1382
Query: 100 ----------LLRRRSQAAQPLQG--EAREAARERAERVRRRLEEAERHKEDLEQHSRQL 147
RR+ + A L+ EAR A AE + +RL E + LE+ R+L
Sbjct: 1383 LQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRL 1442
Query: 148 QEQWEELSSQLFYYGGELQSQKSTEQQLAAQLVTLQNELELAETKCALQEEKLQQDALQT 207
Q++ ++ + L EQQ QLV+ L++++ + D L
Sbjct: 1443 QQELDDATMDL-------------EQQ--RQLVS------------TLEKKQRKFDQLLA 1475
Query: 208 AEAWAIFQEQTVVLQVRPHSDAKEVQVKVMEAAEELDAWQSGRELCDGQLRGVQYSTESL 267
E A+ + V + R ++ +E + + + L+ Q RE + Q R ++ E+L
Sbjct: 1476 EEKAAVL--RAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEAL 1533
Query: 268 M 268
+
Sbjct: 1534 L 1534
Score = 46.6 bits (109), Expect = 3e-05
Identities = 62/253 (24%), Positives = 109/253 (43%), Gaps = 26/253 (10%)
Query: 36 RGGRHLGSVSTAMAATQELLLQLQKDNRDGRQR-KQELEKLMRGLEAES------ESLNQ 88
R R +++ +A E + +L++ GR+R +QEL+ LE + E +
Sbjct: 1413 RAAREAEALTQRLAEKTETVDRLER----GRRRLQQELDDATMDLEQQRQLVSTLEKKQR 1468
Query: 89 RLQDLSERERSLLRRRSQAAQPLQGEAREAARERAERVRRRLEEAERHKEDLEQHSRQLQ 148
+ L E++ + R + + + E RE RA + R LEE + +E+LE+ +R L+
Sbjct: 1469 KFDQLLAEEKAAVLRAVEERERAEAEGRER-EARALSLTRALEEEQEAREELERQNRALR 1527
Query: 149 EQWEELSSQLFYYGGELQS-------QKSTEQQLAAQLVTLQNELELAETKCALQEEKLQ 201
+ E L S G + + L AQ+ L++EL AE E +Q
Sbjct: 1528 AELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQ 1587
Query: 202 QDALQTAEAWAIFQEQTVVLQVRPHSDAKEVQVKVMEAAEELDAWQSGRELCDGQLRGVQ 261
AL+T + Q + + R AK+++ +A E D + R L + ++
Sbjct: 1588 --ALKTQHERDL-QGRDEAGEERRRQLAKQLR----DAEVERDEERKQRTLAVAARKKLE 1640
Query: 262 YSTESLMEEMARA 274
E L +MA A
Sbjct: 1641 GELEELKAQMASA 1653
Score = 45.4 bits (106), Expect = 8e-05
Identities = 55/225 (24%), Positives = 98/225 (43%), Gaps = 27/225 (12%)
Query: 52 QELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPL 111
QEL L+ + +G ++K +LEK+ EA+ + + L L ++ L + R L
Sbjct: 970 QELEAHLEAE--EGARQKLQLEKVTT--EAKMKKFEEDLLLLEDQNSKLSKERKLLEDRL 1025
Query: 112 QGEAREAARERAE-----RVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYYGGELQ 166
+ +AA E + ++R + E ED + + +++ E+L +L ELQ
Sbjct: 1026 AEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQ 1085
Query: 167 SQKSTEQQLAAQLVTLQNELELAETKCALQEEKLQQDALQTAEAWAIFQEQTVVLQVRPH 226
Q +QQ A +L + +EE+LQ AL AE + Q +
Sbjct: 1086 EQMVEQQQRAEEL----------RAQLGRKEEELQA-ALARAEDEGGARAQLL------- 1127
Query: 227 SDAKEVQVKVMEAAEELDAWQSGRELCDGQLRGVQYSTESLMEEM 271
+E Q + EA E+L++ + R + Q R + E+L E+
Sbjct: 1128 KSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGEL 1172
Score = 42.7 bits (99), Expect = 5e-04
Identities = 67/257 (26%), Positives = 120/257 (46%), Gaps = 55/257 (21%)
Query: 48 MAATQELLLQLQKDNRDGRQRKQELEKLMRGLEA---ESESLNQRLQDLSERERSLLRRR 104
+ A EL + ++ RKQELE ++ LEA E E ++++Q +E+ +R
Sbjct: 913 LRAEAELCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQ--TEK-----KRL 965
Query: 105 SQAAQPLQG--EAREAARERAERVRRRLE-EAERHKED---LEQHSRQLQEQWEELSSQL 158
Q Q L+ EA E AR++ + + E + ++ +ED LE + +L ++ + L +L
Sbjct: 966 QQHIQELEAHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRL 1025
Query: 159 FYYGGELQSQKSTEQQLAAQL--VTLQNELELAETKCALQEEKLQQDALQTAEAWAIFQE 216
E SQ + E++ L + L+ E +A+ + L++E+ + L+
Sbjct: 1026 ----AEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEK--------- 1072
Query: 217 QTVVLQVRPHSDAKEVQVKVME---AAEELDAWQSGRELCDGQLRGVQYSTESLMEEMAR 273
L+ R ++ E+Q +++E AEEL A Q GR+ E L +AR
Sbjct: 1073 ----LKRRLDGESSELQEQMVEQQQRAEELRA-QLGRK------------EEELQAALAR 1115
Query: 274 ADRETRLFGGPRALAIR 290
A+ E GG RA ++
Sbjct: 1116 AEDE----GGARAQLLK 1128
Score = 42.7 bits (99), Expect = 5e-04
Identities = 54/232 (23%), Positives = 89/232 (38%), Gaps = 28/232 (12%)
Query: 47 AMAATQELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQ 106
++ Q L + Q+D R + + EK R L E E+L L+D + +
Sbjct: 1129 SLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNA------- 1181
Query: 107 AAQPLQGEAREAARERAERVRRRLEEAERHKEDLEQHSRQLQEQ-WEELSSQLFYYGGEL 165
Q E R + +++ LEE R E Q RQ Q EL+ QL
Sbjct: 1182 -----QQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGK 1236
Query: 166 QSQKSTEQQLAAQLVTLQNELELAETKCALQEEKLQQDALQTAEAWAIFQEQTVVLQVRP 225
+ + T L A++ L+ EL +T E++ ++ LQ E
Sbjct: 1237 GAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEV--------------- 1281
Query: 226 HSDAKEVQVKVMEAAEELDAWQSGRELCDGQLRGVQYSTESLMEEMARADRE 277
A + + EAAE+L Q+ E G L + T L +E++ + +
Sbjct: 1282 QGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQ 1333
Score = 37.4 bits (85), Expect = 0.021
Identities = 35/153 (22%), Positives = 67/153 (43%), Gaps = 5/153 (3%)
Query: 82 ESESLNQRLQDLSERERSLLRRRSQAAQPLQGEAREAARERAERVRRRLEEAERHKEDLE 141
+ E L R Q+L ++ + L ++ ++ LQG + ERA + EAE E E
Sbjct: 867 QDEVLQARAQEL-QKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEAEE 925
Query: 142 QHSRQLQEQWEELSSQLFYYGGELQSQKSTEQQLAAQLVTLQNELELAETKCALQE---E 198
R L + +EL + + ++ +Q+ + LQ ++ E +E +
Sbjct: 926 TRGR-LAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGARQ 984
Query: 199 KLQQDALQTAEAWAIFQEQTVVLQVRPHSDAKE 231
KLQ + + T F+E ++L+ + +KE
Sbjct: 985 KLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKE 1017
Score = 32.7 bits (73), Expect = 0.51
Identities = 40/172 (23%), Positives = 80/172 (46%), Gaps = 15/172 (8%)
Query: 112 QGEAREAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYYGGELQSQKST 171
Q E +A + ++V+ +++ R +L+ QL+E+ L+ QL + T
Sbjct: 867 QDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEAEET 926
Query: 172 EQQLAA---QLVTLQNELEL---AETKCALQ---EEKLQQDALQTAEAWAIFQE---QTV 219
+LAA +L + +ELE E +C+ Q E+K Q +Q EA +E Q +
Sbjct: 927 RGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGARQKL 986
Query: 220 VLQ-VRPHSDAKEVQVKVMEAAEELDAWQSGRELCDGQLRGVQYSTESLMEE 270
L+ V + K+ + ++ ++ R+L + +L ++S+++ EE
Sbjct: 987 QLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRL--AEFSSQAAEEE 1036
>gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]
Length = 2036
Score = 55.1 bits (131), Expect = 1e-07
Identities = 70/291 (24%), Positives = 119/291 (40%), Gaps = 50/291 (17%)
Query: 48 MAATQELLLQLQKDNRDGRQ----RKQELEKLMRGLEAESESLNQRLQDLSERERSLLRR 103
M A + L + ++ R R+ + +E EK ++GLEAE L + L R +
Sbjct: 1708 MQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQD 1767
Query: 104 RSQAAQPLQGE--AREAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYY 161
R + A + ++ A E ++ RL + E E+ + +S L +++ +L Q+
Sbjct: 1768 RDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESL 1827
Query: 162 GGELQSQKSTE-------QQLAAQLVTLQNEL---------------ELAETKCALQEEK 199
EL +++S QQL Q+ L+ L E+K A EE+
Sbjct: 1828 TTELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQ 1887
Query: 200 LQQDA---------LQTAE------AWAIFQEQTVVLQVRPHSDAKEVQVKVM-----EA 239
L+Q+ ++ AE + +E+ V Q+R + ++VK + EA
Sbjct: 1888 LEQETRERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEA 1947
Query: 240 AEELDAWQSGRELCDGQLRGVQYSTESLMEEMARADRETRLFGGPRALAIR 290
EE Q+GR +L V S ES+ E+ RL GP R
Sbjct: 1948 EEEASRAQAGRRRLQRELEDVTESAESMNREVTTL--RNRLRRGPLTFTTR 1996
Score = 53.9 bits (128), Expect = 2e-07
Identities = 69/259 (26%), Positives = 116/259 (44%), Gaps = 30/259 (11%)
Query: 63 RDGRQRKQELEKLMRGLEAESESLNQRL---QDLSERERSLLRRRSQAAQPLQGEAREAA 119
R + +QELEKL R L+ ES L +++ Q +E R+ L R+ + Q A +
Sbjct: 1102 RKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEG 1161
Query: 120 RERAERVRRRLEEAE----RHKEDLEQH---SRQLQEQWEELSSQLFYYGGELQSQKSTE 172
RA+ + + L EA+ +EDLE + ++Q +L +L GEL+ + +
Sbjct: 1162 GARAQ-LLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELED--TLD 1218
Query: 173 QQLAAQLVTLQNELELAETKCALQEEKLQQDA----LQTAEAWAIFQEQTVVLQVRPHSD 228
A Q + + E E+ E K L+EE +A L+ A+ + + Q R
Sbjct: 1219 STNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKG 1278
Query: 229 AKE-----VQVKVMEAAEELDAWQSGRELCDGQLRGVQYSTESLM-----EEMARADRET 278
A E ++ +V E EL + Q+ R+ + + R ++ + + E ARA+
Sbjct: 1279 AWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAE 1338
Query: 279 RLFGGPRALAIRRCVLGAL 297
+L RA A V GAL
Sbjct: 1339 KL---QRAQAELENVSGAL 1354
Score = 52.4 bits (124), Expect = 6e-07
Identities = 63/263 (23%), Positives = 108/263 (41%), Gaps = 31/263 (11%)
Query: 49 AATQEL-------LLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDL--SERERS 99
AA QEL L +L + R+ K EK LEAE L L L + +E
Sbjct: 1250 AAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGE 1309
Query: 100 LLRRRSQ-AAQPLQGEAREAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQL 158
RRR + Q +QG A + R RAE +L+ A+ E++ + + + LS +L
Sbjct: 1310 QRRRRLELQLQEVQGRAGDGERARAE-AAEKLQRAQAELENVSGALNEAESKTIRLSKEL 1368
Query: 159 FYYGGELQSQKSTEQQLAAQLVTLQNELELAETKCALQEEKLQQDA---------LQTAE 209
+L + Q+ + L + + E + A E+L+++A LQTA+
Sbjct: 1369 SSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQ 1428
Query: 210 A----WAIFQEQTV-------VLQVRPHSDAKEVQVKVMEAAEELDAWQSGRELCDGQLR 258
A W QE+ + R +A+ + ++ E E +D + GR +L
Sbjct: 1429 AQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELD 1488
Query: 259 GVQYSTESLMEEMARADRETRLF 281
E + ++ +++ R F
Sbjct: 1489 DATMDLEQQRQLVSTLEKKQRKF 1511
Score = 49.3 bits (116), Expect = 5e-06
Identities = 57/234 (24%), Positives = 102/234 (43%), Gaps = 25/234 (10%)
Query: 56 LQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRR---RSQAAQPLQ 112
L L + + ++ ++ELE+ R L AE E+L D+ + L R QAA L+
Sbjct: 1544 LSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLR 1603
Query: 113 GEAREAARE--RAERVRRRLEEA-----ERHKEDLEQHSRQLQEQWEELSSQLFYYGGEL 165
+ E E AE + RLE +H+ DL+ +E+ +L+ QL +
Sbjct: 1604 AQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQL----RDA 1659
Query: 166 QSQKSTEQQLAAQLVTLQNELELAETKCALQEEKLQQDALQTAEAWAIFQEQTVVLQVRP 225
+ ++ E++ V + +LE L+E K Q + + A+ Q + + Q+
Sbjct: 1660 EVERDEERKQRTLAVAARKKLE-----GELEELKAQMASAGQGKEEAVKQLRKMQAQM-- 1712
Query: 226 HSDAKEVQVKVMEAAEELDAWQSGRELCDGQLRGVQYSTESLMEEMARADRETR 279
KE+ +V E + S + +L+G++ L EE+A +DR R
Sbjct: 1713 ----KELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARR 1762
Score = 47.8 bits (112), Expect = 2e-05
Identities = 56/241 (23%), Positives = 108/241 (44%), Gaps = 45/241 (18%)
Query: 44 VSTAMAATQELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQD-LSERERS--- 99
+S +++T+ L Q+ ++ + K L +R +EAE+ L ++L++ + RER+
Sbjct: 1364 LSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRE 1423
Query: 100 ----------LLRRRSQAAQPLQG--EAREAARERAERVRRRLEEAERHKEDLEQHSRQL 147
RR+ + A L+ EAR A AE + +RL E + LE+ R+L
Sbjct: 1424 LQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRL 1483
Query: 148 QEQWEELSSQLFYYGGELQSQKSTEQQLAAQLVTLQNELELAETKCALQEEKLQQDALQT 207
Q++ ++ + L EQQ QLV+ L++++ + D L
Sbjct: 1484 QQELDDATMDL-------------EQQ--RQLVS------------TLEKKQRKFDQLLA 1516
Query: 208 AEAWAIFQEQTVVLQVRPHSDAKEVQVKVMEAAEELDAWQSGRELCDGQLRGVQYSTESL 267
E A+ + V + R ++ +E + + + L+ Q RE + Q R ++ E+L
Sbjct: 1517 EEKAAVL--RAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEAL 1574
Query: 268 M 268
+
Sbjct: 1575 L 1575
Score = 46.6 bits (109), Expect = 3e-05
Identities = 62/253 (24%), Positives = 109/253 (43%), Gaps = 26/253 (10%)
Query: 36 RGGRHLGSVSTAMAATQELLLQLQKDNRDGRQR-KQELEKLMRGLEAES------ESLNQ 88
R R +++ +A E + +L++ GR+R +QEL+ LE + E +
Sbjct: 1454 RAAREAEALTQRLAEKTETVDRLER----GRRRLQQELDDATMDLEQQRQLVSTLEKKQR 1509
Query: 89 RLQDLSERERSLLRRRSQAAQPLQGEAREAARERAERVRRRLEEAERHKEDLEQHSRQLQ 148
+ L E++ + R + + + E RE RA + R LEE + +E+LE+ +R L+
Sbjct: 1510 KFDQLLAEEKAAVLRAVEERERAEAEGRER-EARALSLTRALEEEQEAREELERQNRALR 1568
Query: 149 EQWEELSSQLFYYGGELQS-------QKSTEQQLAAQLVTLQNELELAETKCALQEEKLQ 201
+ E L S G + + L AQ+ L++EL AE E +Q
Sbjct: 1569 AELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQ 1628
Query: 202 QDALQTAEAWAIFQEQTVVLQVRPHSDAKEVQVKVMEAAEELDAWQSGRELCDGQLRGVQ 261
AL+T + Q + + R AK+++ +A E D + R L + ++
Sbjct: 1629 --ALKTQHERDL-QGRDEAGEERRRQLAKQLR----DAEVERDEERKQRTLAVAARKKLE 1681
Query: 262 YSTESLMEEMARA 274
E L +MA A
Sbjct: 1682 GELEELKAQMASA 1694
Score = 45.4 bits (106), Expect = 8e-05
Identities = 55/225 (24%), Positives = 98/225 (43%), Gaps = 27/225 (12%)
Query: 52 QELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQAAQPL 111
QEL L+ + +G ++K +LEK+ EA+ + + L L ++ L + R L
Sbjct: 1011 QELEAHLEAE--EGARQKLQLEKVTT--EAKMKKFEEDLLLLEDQNSKLSKERKLLEDRL 1066
Query: 112 QGEAREAARERAE-----RVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYYGGELQ 166
+ +AA E + ++R + E ED + + +++ E+L +L ELQ
Sbjct: 1067 AEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQ 1126
Query: 167 SQKSTEQQLAAQLVTLQNELELAETKCALQEEKLQQDALQTAEAWAIFQEQTVVLQVRPH 226
Q +QQ A +L + +EE+LQ AL AE + Q +
Sbjct: 1127 EQMVEQQQRAEEL----------RAQLGRKEEELQA-ALARAEDEGGARAQLL------- 1168
Query: 227 SDAKEVQVKVMEAAEELDAWQSGRELCDGQLRGVQYSTESLMEEM 271
+E Q + EA E+L++ + R + Q R + E+L E+
Sbjct: 1169 KSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGEL 1213
Score = 42.7 bits (99), Expect = 5e-04
Identities = 67/257 (26%), Positives = 120/257 (46%), Gaps = 55/257 (21%)
Query: 48 MAATQELLLQLQKDNRDGRQRKQELEKLMRGLEA---ESESLNQRLQDLSERERSLLRRR 104
+ A EL + ++ RKQELE ++ LEA E E ++++Q +E+ +R
Sbjct: 954 LRAEAELCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQ--TEK-----KRL 1006
Query: 105 SQAAQPLQG--EAREAARERAERVRRRLE-EAERHKED---LEQHSRQLQEQWEELSSQL 158
Q Q L+ EA E AR++ + + E + ++ +ED LE + +L ++ + L +L
Sbjct: 1007 QQHIQELEAHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRL 1066
Query: 159 FYYGGELQSQKSTEQQLAAQL--VTLQNELELAETKCALQEEKLQQDALQTAEAWAIFQE 216
E SQ + E++ L + L+ E +A+ + L++E+ + L+
Sbjct: 1067 ----AEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEK--------- 1113
Query: 217 QTVVLQVRPHSDAKEVQVKVME---AAEELDAWQSGRELCDGQLRGVQYSTESLMEEMAR 273
L+ R ++ E+Q +++E AEEL A Q GR+ E L +AR
Sbjct: 1114 ----LKRRLDGESSELQEQMVEQQQRAEELRA-QLGRK------------EEELQAALAR 1156
Query: 274 ADRETRLFGGPRALAIR 290
A+ E GG RA ++
Sbjct: 1157 AEDE----GGARAQLLK 1169
Score = 42.7 bits (99), Expect = 5e-04
Identities = 54/232 (23%), Positives = 89/232 (38%), Gaps = 28/232 (12%)
Query: 47 AMAATQELLLQLQKDNRDGRQRKQELEKLMRGLEAESESLNQRLQDLSERERSLLRRRSQ 106
++ Q L + Q+D R + + EK R L E E+L L+D + +
Sbjct: 1170 SLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNA------- 1222
Query: 107 AAQPLQGEAREAARERAERVRRRLEEAERHKEDLEQHSRQLQEQ-WEELSSQLFYYGGEL 165
Q E R + +++ LEE R E Q RQ Q EL+ QL
Sbjct: 1223 -----QQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGK 1277
Query: 166 QSQKSTEQQLAAQLVTLQNELELAETKCALQEEKLQQDALQTAEAWAIFQEQTVVLQVRP 225
+ + T L A++ L+ EL +T E++ ++ LQ E
Sbjct: 1278 GAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEV--------------- 1322
Query: 226 HSDAKEVQVKVMEAAEELDAWQSGRELCDGQLRGVQYSTESLMEEMARADRE 277
A + + EAAE+L Q+ E G L + T L +E++ + +
Sbjct: 1323 QGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQ 1374
Score = 37.4 bits (85), Expect = 0.021
Identities = 35/153 (22%), Positives = 67/153 (43%), Gaps = 5/153 (3%)
Query: 82 ESESLNQRLQDLSERERSLLRRRSQAAQPLQGEAREAARERAERVRRRLEEAERHKEDLE 141
+ E L R Q+L ++ + L ++ ++ LQG + ERA + EAE E E
Sbjct: 908 QDEVLQARAQEL-QKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEAEE 966
Query: 142 QHSRQLQEQWEELSSQLFYYGGELQSQKSTEQQLAAQLVTLQNELELAETKCALQE---E 198
R L + +EL + + ++ +Q+ + LQ ++ E +E +
Sbjct: 967 TRGR-LAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGARQ 1025
Query: 199 KLQQDALQTAEAWAIFQEQTVVLQVRPHSDAKE 231
KLQ + + T F+E ++L+ + +KE
Sbjct: 1026 KLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKE 1058
Score = 32.7 bits (73), Expect = 0.51
Identities = 40/172 (23%), Positives = 80/172 (46%), Gaps = 15/172 (8%)
Query: 112 QGEAREAARERAERVRRRLEEAERHKEDLEQHSRQLQEQWEELSSQLFYYGGELQSQKST 171
Q E +A + ++V+ +++ R +L+ QL+E+ L+ QL + T
Sbjct: 908 QDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEAEET 967
Query: 172 EQQLAA---QLVTLQNELEL---AETKCALQ---EEKLQQDALQTAEAWAIFQE---QTV 219
+LAA +L + +ELE E +C+ Q E+K Q +Q EA +E Q +
Sbjct: 968 RGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGARQKL 1027
Query: 220 VLQ-VRPHSDAKEVQVKVMEAAEELDAWQSGRELCDGQLRGVQYSTESLMEE 270
L+ V + K+ + ++ ++ R+L + +L ++S+++ EE
Sbjct: 1028 QLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRL--AEFSSQAAEEE 1077
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.130 0.366
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 12,876,244
Number of Sequences: 37866
Number of extensions: 569713
Number of successful extensions: 10968
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 391
Number of HSP's successfully gapped in prelim test: 927
Number of HSP's that attempted gapping in prelim test: 4570
Number of HSP's gapped (non-prelim): 4144
length of query: 357
length of database: 18,247,518
effective HSP length: 103
effective length of query: 254
effective length of database: 14,347,320
effective search space: 3644219280
effective search space used: 3644219280
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.