Search of human proteins with 118402580

Search of human proteins with 118402580

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|118402580 anaphase-promoting complex, subunit 6 [Homo
sapiens]
         (620 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|118402578 anaphase-promoting complex, subunit 6 [Homo sapiens]    1266   0.0  
gi|118402580 anaphase-promoting complex, subunit 6 [Homo sapiens]    1266   0.0  
gi|167466177 cell division cycle protein 27 isoform 1 [Homo sapi...    80   4e-15
gi|167466175 cell division cycle protein 27 isoform 2 [Homo sapi...    80   4e-15
gi|118402596 cell division cycle protein 23 [Homo sapiens]             62   2e-09
gi|32307150 O-linked GlcNAc transferase isoform 2 [Homo sapiens]       60   6e-09
gi|32307148 O-linked GlcNAc transferase isoform 1 [Homo sapiens]       60   6e-09
gi|83415184 transmembrane and tetratricopeptide repeat containin...    48   3e-05
gi|7661950 SH2 domain binding protein 1 [Homo sapiens]                 47   5e-05
gi|118766328 transmembrane and tetratricopeptide repeat containi...    43   8e-04
gi|118766330 transmembrane and tetratricopeptide repeat containi...    43   8e-04
gi|34304360 nephrocystin 3 [Homo sapiens]                              41   0.004
gi|28558993 intraflagellar transport 88 homolog isoform 1 [Homo ...    40   0.006
gi|28329439 intraflagellar transport 88 homolog isoform 2 [Homo ...    40   0.006
gi|224028289 tetratricopeptide repeat domain 28 [Homo sapiens]         40   0.008
gi|229577238 tetratricopeptide repeat domain 18 [Homo sapiens]         37   0.041
gi|116534937 interferon-induced protein with tetratricopeptide r...    37   0.041
gi|25952122 Bardet-Biedl syndrome 4 [Homo sapiens]                     37   0.041
gi|22749211 transmembrane and tetratricopeptide repeat containin...    37   0.041
gi|110225358 tetratricopeptide repeat domain 7A [Homo sapiens]         37   0.041
gi|224548927 G-protein signaling modulator 1 (AGS3-like, C. eleg...    37   0.071
gi|224548925 G-protein signaling modulator 1 (AGS3-like, C. eleg...    37   0.071
gi|41871960 kinesin-like 8 isoform b [Homo sapiens]                    35   0.16 
gi|41871955 kinesin-like 8 isoform a [Homo sapiens]                    35   0.16 
gi|41871946 kinesin-like 8 isoform a [Homo sapiens]                    35   0.16 
gi|60685231 tetratricopeptide repeat domain 7B [Homo sapiens]          35   0.16 
gi|53759120 tetratricopeptide repeat domain 8 isoform A [Homo sa...    34   0.46 
gi|38146008 tetratricopeptide repeat domain 8 isoform C [Homo sa...    34   0.46 
gi|38146012 tetratricopeptide repeat domain 8 isoform B [Homo sa...    34   0.46 
gi|42475558 SMG-7 homolog isoform 1 [Homo sapiens]                     34   0.46 

>gi|118402578 anaphase-promoting complex, subunit 6 [Homo sapiens]
          Length = 620

 Score = 1266 bits (3277), Expect = 0.0
 Identities = 620/620 (100%), Positives = 620/620 (100%)

Query: 1   MNLERLRKRVRQYLDQQQYQSALFWADKVASLSREEPQDIYWLAQCLYLTAQYHRAAHAL 60
           MNLERLRKRVRQYLDQQQYQSALFWADKVASLSREEPQDIYWLAQCLYLTAQYHRAAHAL
Sbjct: 1   MNLERLRKRVRQYLDQQQYQSALFWADKVASLSREEPQDIYWLAQCLYLTAQYHRAAHAL 60

Query: 61  RSRKLDKLYEACRYLAARCHYAAKEHQQALDVLDMEEPINKRLFEKYLKDESGFKDPSSD 120
           RSRKLDKLYEACRYLAARCHYAAKEHQQALDVLDMEEPINKRLFEKYLKDESGFKDPSSD
Sbjct: 61  RSRKLDKLYEACRYLAARCHYAAKEHQQALDVLDMEEPINKRLFEKYLKDESGFKDPSSD 120

Query: 121 WEMSQSSIKSSICLLRGKIYDALDNRTLATYSYKEALKLDVYCFEAFDLLTSHHMLTAQE 180
           WEMSQSSIKSSICLLRGKIYDALDNRTLATYSYKEALKLDVYCFEAFDLLTSHHMLTAQE
Sbjct: 121 WEMSQSSIKSSICLLRGKIYDALDNRTLATYSYKEALKLDVYCFEAFDLLTSHHMLTAQE 180

Query: 181 EKELLESLPLSKLCNEEQELLRFLFENKLKKYNKPSETVIPESVDGLQENLDVVVSLAER 240
           EKELLESLPLSKLCNEEQELLRFLFENKLKKYNKPSETVIPESVDGLQENLDVVVSLAER
Sbjct: 181 EKELLESLPLSKLCNEEQELLRFLFENKLKKYNKPSETVIPESVDGLQENLDVVVSLAER 240

Query: 241 HYYNCDFKMCYKLTSVVMEKDPFHASCLPVHIGTLVELNKANELFYLSHKLVDLYPSNPV 300
           HYYNCDFKMCYKLTSVVMEKDPFHASCLPVHIGTLVELNKANELFYLSHKLVDLYPSNPV
Sbjct: 241 HYYNCDFKMCYKLTSVVMEKDPFHASCLPVHIGTLVELNKANELFYLSHKLVDLYPSNPV 300

Query: 301 SWFAVGCYYLMVGHKNEHARRYLSKATTLEKTYGPAWIAYGHSFAVESEHDQAMAAYFTA 360
           SWFAVGCYYLMVGHKNEHARRYLSKATTLEKTYGPAWIAYGHSFAVESEHDQAMAAYFTA
Sbjct: 301 SWFAVGCYYLMVGHKNEHARRYLSKATTLEKTYGPAWIAYGHSFAVESEHDQAMAAYFTA 360

Query: 361 AQLMKGCHLPMLYIGLEYGLTNNSKLAERFFSQALSIAPEDPFVMHEVGVVAFQNGEWKT 420
           AQLMKGCHLPMLYIGLEYGLTNNSKLAERFFSQALSIAPEDPFVMHEVGVVAFQNGEWKT
Sbjct: 361 AQLMKGCHLPMLYIGLEYGLTNNSKLAERFFSQALSIAPEDPFVMHEVGVVAFQNGEWKT 420

Query: 421 AEKWFLDALEKIKAIGNEVTVDKWEPLLNNLGHVCRKLKKYAEALDYHRQALVLIPQNAS 480
           AEKWFLDALEKIKAIGNEVTVDKWEPLLNNLGHVCRKLKKYAEALDYHRQALVLIPQNAS
Sbjct: 421 AEKWFLDALEKIKAIGNEVTVDKWEPLLNNLGHVCRKLKKYAEALDYHRQALVLIPQNAS 480

Query: 481 TYSAIGYIHSLMGNFENAVDYFHTALGLRRDDTFSVTMLGHCIEMYIGDSEAYIGADIKD 540
           TYSAIGYIHSLMGNFENAVDYFHTALGLRRDDTFSVTMLGHCIEMYIGDSEAYIGADIKD
Sbjct: 481 TYSAIGYIHSLMGNFENAVDYFHTALGLRRDDTFSVTMLGHCIEMYIGDSEAYIGADIKD 540

Query: 541 KLKCYDFDVHTMKTLKNIISPPWDFREFEVEKQTAEETGLTPLETSRKTPDSRPSLEETF 600
           KLKCYDFDVHTMKTLKNIISPPWDFREFEVEKQTAEETGLTPLETSRKTPDSRPSLEETF
Sbjct: 541 KLKCYDFDVHTMKTLKNIISPPWDFREFEVEKQTAEETGLTPLETSRKTPDSRPSLEETF 600

Query: 601 EIEMNESDMMLETSMSDHST 620
           EIEMNESDMMLETSMSDHST
Sbjct: 601 EIEMNESDMMLETSMSDHST 620


>gi|118402580 anaphase-promoting complex, subunit 6 [Homo sapiens]
          Length = 620

 Score = 1266 bits (3277), Expect = 0.0
 Identities = 620/620 (100%), Positives = 620/620 (100%)

Query: 1   MNLERLRKRVRQYLDQQQYQSALFWADKVASLSREEPQDIYWLAQCLYLTAQYHRAAHAL 60
           MNLERLRKRVRQYLDQQQYQSALFWADKVASLSREEPQDIYWLAQCLYLTAQYHRAAHAL
Sbjct: 1   MNLERLRKRVRQYLDQQQYQSALFWADKVASLSREEPQDIYWLAQCLYLTAQYHRAAHAL 60

Query: 61  RSRKLDKLYEACRYLAARCHYAAKEHQQALDVLDMEEPINKRLFEKYLKDESGFKDPSSD 120
           RSRKLDKLYEACRYLAARCHYAAKEHQQALDVLDMEEPINKRLFEKYLKDESGFKDPSSD
Sbjct: 61  RSRKLDKLYEACRYLAARCHYAAKEHQQALDVLDMEEPINKRLFEKYLKDESGFKDPSSD 120

Query: 121 WEMSQSSIKSSICLLRGKIYDALDNRTLATYSYKEALKLDVYCFEAFDLLTSHHMLTAQE 180
           WEMSQSSIKSSICLLRGKIYDALDNRTLATYSYKEALKLDVYCFEAFDLLTSHHMLTAQE
Sbjct: 121 WEMSQSSIKSSICLLRGKIYDALDNRTLATYSYKEALKLDVYCFEAFDLLTSHHMLTAQE 180

Query: 181 EKELLESLPLSKLCNEEQELLRFLFENKLKKYNKPSETVIPESVDGLQENLDVVVSLAER 240
           EKELLESLPLSKLCNEEQELLRFLFENKLKKYNKPSETVIPESVDGLQENLDVVVSLAER
Sbjct: 181 EKELLESLPLSKLCNEEQELLRFLFENKLKKYNKPSETVIPESVDGLQENLDVVVSLAER 240

Query: 241 HYYNCDFKMCYKLTSVVMEKDPFHASCLPVHIGTLVELNKANELFYLSHKLVDLYPSNPV 300
           HYYNCDFKMCYKLTSVVMEKDPFHASCLPVHIGTLVELNKANELFYLSHKLVDLYPSNPV
Sbjct: 241 HYYNCDFKMCYKLTSVVMEKDPFHASCLPVHIGTLVELNKANELFYLSHKLVDLYPSNPV 300

Query: 301 SWFAVGCYYLMVGHKNEHARRYLSKATTLEKTYGPAWIAYGHSFAVESEHDQAMAAYFTA 360
           SWFAVGCYYLMVGHKNEHARRYLSKATTLEKTYGPAWIAYGHSFAVESEHDQAMAAYFTA
Sbjct: 301 SWFAVGCYYLMVGHKNEHARRYLSKATTLEKTYGPAWIAYGHSFAVESEHDQAMAAYFTA 360

Query: 361 AQLMKGCHLPMLYIGLEYGLTNNSKLAERFFSQALSIAPEDPFVMHEVGVVAFQNGEWKT 420
           AQLMKGCHLPMLYIGLEYGLTNNSKLAERFFSQALSIAPEDPFVMHEVGVVAFQNGEWKT
Sbjct: 361 AQLMKGCHLPMLYIGLEYGLTNNSKLAERFFSQALSIAPEDPFVMHEVGVVAFQNGEWKT 420

Query: 421 AEKWFLDALEKIKAIGNEVTVDKWEPLLNNLGHVCRKLKKYAEALDYHRQALVLIPQNAS 480
           AEKWFLDALEKIKAIGNEVTVDKWEPLLNNLGHVCRKLKKYAEALDYHRQALVLIPQNAS
Sbjct: 421 AEKWFLDALEKIKAIGNEVTVDKWEPLLNNLGHVCRKLKKYAEALDYHRQALVLIPQNAS 480

Query: 481 TYSAIGYIHSLMGNFENAVDYFHTALGLRRDDTFSVTMLGHCIEMYIGDSEAYIGADIKD 540
           TYSAIGYIHSLMGNFENAVDYFHTALGLRRDDTFSVTMLGHCIEMYIGDSEAYIGADIKD
Sbjct: 481 TYSAIGYIHSLMGNFENAVDYFHTALGLRRDDTFSVTMLGHCIEMYIGDSEAYIGADIKD 540

Query: 541 KLKCYDFDVHTMKTLKNIISPPWDFREFEVEKQTAEETGLTPLETSRKTPDSRPSLEETF 600
           KLKCYDFDVHTMKTLKNIISPPWDFREFEVEKQTAEETGLTPLETSRKTPDSRPSLEETF
Sbjct: 541 KLKCYDFDVHTMKTLKNIISPPWDFREFEVEKQTAEETGLTPLETSRKTPDSRPSLEETF 600

Query: 601 EIEMNESDMMLETSMSDHST 620
           EIEMNESDMMLETSMSDHST
Sbjct: 601 EIEMNESDMMLETSMSDHST 620


>gi|167466177 cell division cycle protein 27 isoform 1 [Homo
           sapiens]
          Length = 830

 Score = 80.5 bits (197), Expect = 4e-15
 Identities = 72/292 (24%), Positives = 125/292 (42%), Gaps = 29/292 (9%)

Query: 234 VVSLAERHYYNCDFKMCY---------------KLTSVVMEKDPFHASCLPVHIGTLVEL 278
           ++S    H+YN  + +C                ++ S V   + +    + ++  TL  L
Sbjct: 493 ILSHLPSHHYNTGWVLCQIGRAYFELSEYMQAERIFSEVRRIENYRVEGMEIYSTTLWHL 552

Query: 279 NKANELFYLSHKLVDLYPSNPVSWFAVG-CYYLMVGHKNEHARRYLSKATTLEKTYGPAW 337
            K   L  LS  L D+  ++P +W A G C+ L   H  + A ++  +A  ++  Y  A+
Sbjct: 553 QKDVALSVLSKDLTDMDKNSPEAWCAAGNCFSLQREH--DIAIKFFQRAIQVDPNYAYAY 610

Query: 338 IAYGHSFAVESEHDQAMAAYFTAAQLMKGCHLPMLYIGLEYGLTNNSKLAERFFSQALSI 397
              GH F +  E D+A+A +  A ++    +     +G+ Y       LAE  F +AL I
Sbjct: 611 TLLGHEFVLTEELDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDI 670

Query: 398 APEDPFVMHEVGVVAFQNGEWKTAEKWFLDALEKIKAIGNEVTVDKWEPLLN-NLGHVCR 456
            P+   ++  +GVV       K +EK  LD L K       + +D   PL   +   V  
Sbjct: 671 NPQSSVLLCHIGVV---QHALKKSEK-ALDTLNK------AIVIDPKNPLCKFHRASVLF 720

Query: 457 KLKKYAEALDYHRQALVLIPQNASTYSAIGYIHSLMGNFENAVDYFHTALGL 508
             +KY  AL    +   ++P+ +  Y  IG ++  +G    A+  F  A+ L
Sbjct: 721 ANEKYKSALQELEELKQIVPKESLVYFLIGKVYKKLGQTHLALMNFSWAMDL 772


>gi|167466175 cell division cycle protein 27 isoform 2 [Homo
           sapiens]
          Length = 824

 Score = 80.5 bits (197), Expect = 4e-15
 Identities = 72/292 (24%), Positives = 125/292 (42%), Gaps = 29/292 (9%)

Query: 234 VVSLAERHYYNCDFKMCY---------------KLTSVVMEKDPFHASCLPVHIGTLVEL 278
           ++S    H+YN  + +C                ++ S V   + +    + ++  TL  L
Sbjct: 487 ILSHLPSHHYNTGWVLCQIGRAYFELSEYMQAERIFSEVRRIENYRVEGMEIYSTTLWHL 546

Query: 279 NKANELFYLSHKLVDLYPSNPVSWFAVG-CYYLMVGHKNEHARRYLSKATTLEKTYGPAW 337
            K   L  LS  L D+  ++P +W A G C+ L   H  + A ++  +A  ++  Y  A+
Sbjct: 547 QKDVALSVLSKDLTDMDKNSPEAWCAAGNCFSLQREH--DIAIKFFQRAIQVDPNYAYAY 604

Query: 338 IAYGHSFAVESEHDQAMAAYFTAAQLMKGCHLPMLYIGLEYGLTNNSKLAERFFSQALSI 397
              GH F +  E D+A+A +  A ++    +     +G+ Y       LAE  F +AL I
Sbjct: 605 TLLGHEFVLTEELDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDI 664

Query: 398 APEDPFVMHEVGVVAFQNGEWKTAEKWFLDALEKIKAIGNEVTVDKWEPLLN-NLGHVCR 456
            P+   ++  +GVV       K +EK  LD L K       + +D   PL   +   V  
Sbjct: 665 NPQSSVLLCHIGVV---QHALKKSEK-ALDTLNK------AIVIDPKNPLCKFHRASVLF 714

Query: 457 KLKKYAEALDYHRQALVLIPQNASTYSAIGYIHSLMGNFENAVDYFHTALGL 508
             +KY  AL    +   ++P+ +  Y  IG ++  +G    A+  F  A+ L
Sbjct: 715 ANEKYKSALQELEELKQIVPKESLVYFLIGKVYKKLGQTHLALMNFSWAMDL 766


>gi|118402596 cell division cycle protein 23 [Homo sapiens]
          Length = 597

 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 88/394 (22%), Positives = 156/394 (39%), Gaps = 45/394 (11%)

Query: 32  LSREEPQDI--YWLAQCLYLTAQYHRAAHALR---SRKLDKLYEACRYLAARCHYAAKEH 86
           ++ E+ QD+  Y LA+  +   +Y RAAH L    S+K   LY   RYL+       K+ 
Sbjct: 76  ITEEDAQDMDAYTLAKAYFDVKEYDRAAHFLHGCNSKKAYFLYMYSRYLSGE----KKKD 131

Query: 87  QQALDVLD-MEEPINKRLFEKYLKDESGFKDPSSDWEMSQSSIKSSICLLRGKIYDALDN 145
            + +D L  +E+   K    + L+ E   K  + +       +      L G +   LD 
Sbjct: 132 DETVDSLGPLEKGQVKNEALRELRVELSKKHQARE-------LDGFGLYLYGVVLRKLD- 183

Query: 146 RTLATYSYKEALKLDVYCFEAFDLLTSH-----HMLTAQEEKELLESLPLSKLCNEEQEL 200
                   KEA+ + V   EA  +L  H      +     +KE+L+ L L     +E  L
Sbjct: 184 ------LVKEAIDVFV---EATHVLPLHWGAWLELCNLITDKEMLKFLSLPDTWMKEFFL 234

Query: 201 LRF-----LFENKLKKYNKPSETVIPESVDGLQENLDVVVSLAERHYYNCDFKMCYKLTS 255
                   L E  L+KY    +        G  ++  +V  +A  ++   D      + +
Sbjct: 235 AHIYTELQLIEEALQKYQNLIDV-------GFSKSSYIVSQIAVAYHNIRDIDKALSIFN 287

Query: 256 VVMEKDPFHASCLPVHIGTLVELNKANELFYLSHKLVDLYPSNPVSWFAVGCYYLMVGHK 315
            + ++DP+    +      L   +  +EL YL+H L ++      +   +G YY +   +
Sbjct: 288 ELRKQDPYRIENMDTFSNLLYVRSMKSELSYLAHNLCEIDKYRVETCCVIGNYYSLRS-Q 346

Query: 316 NEHARRYLSKATTLEKTYGPAWIAYGHSFAVESEHDQAMAAYFTAAQLMKGCHLPMLYIG 375
           +E A  Y  +A  L   Y  AW   GH +        A+ AY  A ++ K  +     +G
Sbjct: 347 HEKAALYFQRALKLNPRYLGAWTLMGHEYMEMKNTSAAIQAYRHAIEVNKRDYRAWYGLG 406

Query: 376 LEYGLTNNSKLAERFFSQALSIAPEDPFVMHEVG 409
             Y +         ++ +A  + P D  ++  +G
Sbjct: 407 QTYEILKMPFYCLYYYRRAHQLRPNDSRMLVALG 440


>gi|32307150 O-linked GlcNAc transferase isoform 2 [Homo sapiens]
          Length = 1036

 Score = 60.1 bits (144), Expect = 6e-09
 Identities = 62/283 (21%), Positives = 119/283 (42%), Gaps = 26/283 (9%)

Query: 267 CLPVHIGTLVE-LNKANELFYLSHKLVDLYPSNPVSWFAVGCYYLMVGHKNEHARRYLSK 325
           C+   +G L++ L +  E      K ++  P+  V+W  +GC +   G +   A  +  K
Sbjct: 148 CVRSDLGNLLKALGRLEEAKACYLKAIETQPNFAVAWSNLGCVFNAQG-EIWLAIHHFEK 206

Query: 326 ATTLEKTYGPAWIAYGHSFAVESEHDQAMAAYFTAAQLMKG---CHLPMLYIGLEYGLTN 382
           A TL+  +  A+I  G+        D+A+AAY  A  L       H  +  +  E GL +
Sbjct: 207 AVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSLSPNHAVVHGNLACVYYEQGLID 266

Query: 383 NSKLAERFFSQALSIAPEDPFVMHEVGVVAFQNGEWKTAEKWFLDALEKIKAIGNEVTVD 442
              LA   + +A+ + P  P     +     + G    AE  +  AL       +     
Sbjct: 267 ---LAIDTYRRAIELQPHFPDAYCNLANALKEKGSVAEAEDCYNTALRLCPTHADS---- 319

Query: 443 KWEPLLNNLGHVCRKLKKYAEALDYHRQALVLIPQNASTYSAIGYIHSLMGNFENAVDYF 502
                LNNL ++ R+     EA+  +R+AL + P+ A+ +S +  +    G  + A+ ++
Sbjct: 320 -----LNNLANIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHY 374

Query: 503 HTALGLRRDDTFSVTMLGHCIEMYIGDSEAYIGADIKDKLKCY 545
             A+ +      + + +G+ ++            D++  L+CY
Sbjct: 375 KEAIRISPTFADAYSNMGNTLKEM---------QDVQGALQCY 408



 Score = 32.7 bits (73), Expect = 1.0
 Identities = 23/73 (31%), Positives = 36/73 (49%), Gaps = 4/73 (5%)

Query: 443 KWEPLL----NNLGHVCRKLKKYAEALDYHRQALVLIPQNASTYSAIGYIHSLMGNFENA 498
           K  PLL    +NLG+V ++  +  EA++++R AL L P     Y  +       G+ E A
Sbjct: 73  KQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVAAGDMEGA 132

Query: 499 VDYFHTALGLRRD 511
           V  + +AL    D
Sbjct: 133 VQAYVSALQYNPD 145


>gi|32307148 O-linked GlcNAc transferase isoform 1 [Homo sapiens]
          Length = 1046

 Score = 60.1 bits (144), Expect = 6e-09
 Identities = 62/283 (21%), Positives = 119/283 (42%), Gaps = 26/283 (9%)

Query: 267 CLPVHIGTLVE-LNKANELFYLSHKLVDLYPSNPVSWFAVGCYYLMVGHKNEHARRYLSK 325
           C+   +G L++ L +  E      K ++  P+  V+W  +GC +   G +   A  +  K
Sbjct: 158 CVRSDLGNLLKALGRLEEAKACYLKAIETQPNFAVAWSNLGCVFNAQG-EIWLAIHHFEK 216

Query: 326 ATTLEKTYGPAWIAYGHSFAVESEHDQAMAAYFTAAQLMKG---CHLPMLYIGLEYGLTN 382
           A TL+  +  A+I  G+        D+A+AAY  A  L       H  +  +  E GL +
Sbjct: 217 AVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSLSPNHAVVHGNLACVYYEQGLID 276

Query: 383 NSKLAERFFSQALSIAPEDPFVMHEVGVVAFQNGEWKTAEKWFLDALEKIKAIGNEVTVD 442
              LA   + +A+ + P  P     +     + G    AE  +  AL       +     
Sbjct: 277 ---LAIDTYRRAIELQPHFPDAYCNLANALKEKGSVAEAEDCYNTALRLCPTHADS---- 329

Query: 443 KWEPLLNNLGHVCRKLKKYAEALDYHRQALVLIPQNASTYSAIGYIHSLMGNFENAVDYF 502
                LNNL ++ R+     EA+  +R+AL + P+ A+ +S +  +    G  + A+ ++
Sbjct: 330 -----LNNLANIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHY 384

Query: 503 HTALGLRRDDTFSVTMLGHCIEMYIGDSEAYIGADIKDKLKCY 545
             A+ +      + + +G+ ++            D++  L+CY
Sbjct: 385 KEAIRISPTFADAYSNMGNTLKEM---------QDVQGALQCY 418



 Score = 32.7 bits (73), Expect = 1.0
 Identities = 23/73 (31%), Positives = 36/73 (49%), Gaps = 4/73 (5%)

Query: 443 KWEPLL----NNLGHVCRKLKKYAEALDYHRQALVLIPQNASTYSAIGYIHSLMGNFENA 498
           K  PLL    +NLG+V ++  +  EA++++R AL L P     Y  +       G+ E A
Sbjct: 83  KQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVAAGDMEGA 142

Query: 499 VDYFHTALGLRRD 511
           V  + +AL    D
Sbjct: 143 VQAYVSALQYNPD 155


>gi|83415184 transmembrane and tetratricopeptide repeat containing 1
           [Homo sapiens]
          Length = 774

 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 72/313 (23%), Positives = 120/313 (38%), Gaps = 39/313 (12%)

Query: 200 LLRFLFENKLKKYNK---PSETVIPESVDGLQENLDVVVSLAERHYYNCDF-------KM 249
           LL  LF  K  K N+     E++    V  L  N  V       HY   +F       K 
Sbjct: 341 LLLLLFSWKTVKQNEIWLSRESLFRSGVQTLPHNAKV-------HYNYANFLKDQGRNKE 393

Query: 250 CYKLTSVVMEKDPFHASCLPVHIGTLVELNKANELFYLSHKLVDLYPSNPVSWFAVGCYY 309
                   ++  P HAS L  ++GTL       +++Y   + + L+P +  + F +G   
Sbjct: 394 AIYHYRTALKLYPRHASALN-NLGTLTRDTAEAKMYY--QRALQLHPQHNRALFNLG-NL 449

Query: 310 LMVGHKNEHARRYLSKATTLEKTYGPAWIAYGHSFAVESEHDQAMAAYFTAAQLMKGCHL 369
           L    K E A   L  +      +  A+ +     A +    +A   Y T    +K C  
Sbjct: 450 LKSQEKKEEAITLLKDSIKYGPEFADAYSSLASLLAEQERFKEAEEIYQTG---IKNCP- 505

Query: 370 PMLYIGLEYGL----TNNSKLAERFFSQALSIAPEDPFVMHEVGVVAFQNGEWKTAEKWF 425
               +   YG+    T   + A   + QA+ ++P     M  +G +    GE   AE+W+
Sbjct: 506 DSSDLHNNYGVFLVDTGLPEKAVAHYQQAIKLSPSHHVAMVNLGRLYRSLGENSMAEEWY 565

Query: 426 LDALEKIKAIGNEVTVDKWEPLLNNLGHVCRKLKKYAEALDYHRQALVLIPQNASTYSAI 485
             AL+          V     +L+ LG +     +Y EAL  +++A  L P       A+
Sbjct: 566 KRALQ----------VAHKAEILSPLGALYYNTGRYEEALQIYQEAAALQPSQRELRLAL 615

Query: 486 GYIHSLMGNFENA 498
             + ++MG  + A
Sbjct: 616 AQVLAVMGQTKEA 628



 Score = 36.6 bits (83), Expect = 0.071
 Identities = 80/365 (21%), Positives = 133/365 (36%), Gaps = 45/365 (12%)

Query: 149 ATYSYKEALKLDVYCFEAFDLLTSHHMLTAQEEKELLESLPLSKLCNEEQELLRFLFENK 208
           A Y Y+ ALKL      A + L +    TA+ +     +L L    + +     F   N 
Sbjct: 394 AIYHYRTALKLYPRHASALNNLGTLTRDTAEAKMYYQRALQL----HPQHNRALFNLGNL 449

Query: 209 LKKYNKPSE--TVIPESVDGLQENLDVVVSLAERHYYNCDFKMCYKLTSVVMEKDPFHAS 266
           LK   K  E  T++ +S+    E  D   SLA        FK   ++    ++  P  +S
Sbjct: 450 LKSQEKKEEAITLLKDSIKYGPEFADAYSSLASLLAEQERFKEAEEIYQTGIKNCP-DSS 508

Query: 267 CLPVHIGT-LVELNKANELFYLSHKLVDLYPSNPVSWFAVGCYY---------------- 309
            L  + G  LV+     +      + + L PS+ V+   +G  Y                
Sbjct: 509 DLHNNYGVFLVDTGLPEKAVAHYQQAIKLSPSHHVAMVNLGRLYRSLGENSMAEEWYKRA 568

Query: 310 LMVGHKNE----------------HARRYLSKATTLEKTYGPAWIAYGHSFAVESEHDQA 353
           L V HK E                 A +   +A  L+ +     +A     AV  +  +A
Sbjct: 569 LQVAHKAEILSPLGALYYNTGRYEEALQIYQEAAALQPSQRELRLALAQVLAVMGQTKEA 628

Query: 354 MAAYFTAAQLMKGCHLPMLYIGLEYGLTNNSKLAERFFSQALSIAPEDPFVMHEVGVVAF 413
                       GC      +   Y    N   A     +AL + P+DP V+ E+    F
Sbjct: 629 EKMTNHIVSEETGCLECYRLLSAIYSKQENHDKALDAIDKALQLKPKDPKVISEL---FF 685

Query: 414 QNGEWKTAEKWFLDALEKIKAIGNEVTVDKWEPLLNNLGHVCRKLKKYAEALDYHRQALV 473
             G  +  E+  LD   +   +  ++  D+ +  +N +G +     KY  A  Y+ +AL 
Sbjct: 686 TKGN-QLREQNLLDKAFESYRVAVQLNPDQAQAWMN-MGGIQHIKGKYVSARAYYERALQ 743

Query: 474 LIPQN 478
           L+P +
Sbjct: 744 LVPDS 748


>gi|7661950 SH2 domain binding protein 1 [Homo sapiens]
          Length = 1173

 Score = 47.0 bits (110), Expect = 5e-05
 Identities = 44/191 (23%), Positives = 83/191 (43%), Gaps = 20/191 (10%)

Query: 338 IAYGHSFAVESEHDQAMAAYFTAAQLMKGCHLPMLYIGLEYGLTNNSKLAERFFSQALSI 397
           IA GH   V  ++   + A+   AQ+++   +         G  +    A R   + +  
Sbjct: 396 IAKGHLKKVTEQYPDDVEAWIELAQILEQTDIQ--------GALSAYGTATRILQEKVQ- 446

Query: 398 APEDPFVMHEVGVVAFQNGEWKTAEKWFLDALEKIKAIG-------NEVTVDKWEPLLNN 450
           A   P +++ VG + F+ G    A+K+FL +L++ KA         N ++V        N
Sbjct: 447 ADVPPEILNNVGALHFRLGNLGEAKKYFLASLDRAKAEAEHDEHYYNAISVTT----SYN 502

Query: 451 LGHVCRKLKKYAEALDYHRQALVLIPQNASTYSAIGYIHSLMGNFENAVDYFHTALGLRR 510
           L  +   + ++ EA   ++  L   P     Y  +G +    GNF  A D+F  AL + +
Sbjct: 503 LARLYEAMCEFHEAEKLYKNILREHPNYVDCYLRLGAMARDKGNFYEASDWFKEALQINQ 562

Query: 511 DDTFSVTMLGH 521
           D   + +++G+
Sbjct: 563 DHPDAWSLIGN 573


>gi|118766328 transmembrane and tetratricopeptide repeat containing
           4 isoform 2 [Homo sapiens]
          Length = 741

 Score = 43.1 bits (100), Expect = 8e-04
 Identities = 29/123 (23%), Positives = 57/123 (46%), Gaps = 9/123 (7%)

Query: 388 ERFFSQALSIAPEDPFVMHEVGVVAFQNGEWKTAEKWFLDALEKIKAIGNEVTVDKWEPL 447
           E+ F  ALS+ P +  V + +G      G    A +++ +A+             K+   
Sbjct: 468 EQLFRSALSVCPLNAKVHYNIGKNLADKGNQTAAIRYYREAVR---------LNPKYVHA 518

Query: 448 LNNLGHVCRKLKKYAEALDYHRQALVLIPQNASTYSAIGYIHSLMGNFENAVDYFHTALG 507
           +NNLG++ ++  +  EA +    A+ + P  A+ +  +G + + +  FE A   + TA+ 
Sbjct: 519 MNNLGNILKERNELQEAEELLSLAVQIQPDFAAAWMNLGIVQNSLKRFEAAEQSYRTAIK 578

Query: 508 LRR 510
            RR
Sbjct: 579 HRR 581



 Score = 37.0 bits (84), Expect = 0.054
 Identities = 37/154 (24%), Positives = 64/154 (41%), Gaps = 4/154 (2%)

Query: 277 ELNKANELFYLSHKLVDLYPSNPVSWFAVGCYYLMVGHKNEHARRYLSKATTLEKTYGPA 336
           EL +A EL  L+   V + P    +W  +G     +  + E A +    A    + Y   
Sbjct: 531 ELQEAEELLSLA---VQIQPDFAAAWMNLGIVQNSL-KRFEAAEQSYRTAIKHRRKYPDC 586

Query: 337 WIAYGHSFAVESEHDQAMAAYFTAAQLMKGCHLPMLYIGLEYGLTNNSKLAERFFSQALS 396
           +   G  +A  + H  A+ A+  A  L     L    + +    T N   AE    +AL 
Sbjct: 587 YYNLGRLYADLNRHVDALNAWRNATVLKPEHSLAWNNMIILLDNTGNLAQAEAVGREALE 646

Query: 397 IAPEDPFVMHEVGVVAFQNGEWKTAEKWFLDALE 430
           + P D  +M  +  V  ++ ++K +E  FL A++
Sbjct: 647 LIPNDHSLMFSLANVLGKSQKYKESEALFLKAIK 680



 Score = 30.0 bits (66), Expect = 6.6
 Identities = 27/142 (19%), Positives = 63/142 (44%), Gaps = 9/142 (6%)

Query: 374 IGLEYGLTNNSKLAERFFSQALSIAPEDPFVMHEVGVVAFQNGEWKTAEKWFLDALEKIK 433
           IG       N   A R++ +A+ + P+    M+ +G +  +  E + AE+        + 
Sbjct: 488 IGKNLADKGNQTAAIRYYREAVRLNPKYVHAMNNLGNILKERNELQEAEE--------LL 539

Query: 434 AIGNEVTVDKWEPLLNNLGHVCRKLKKYAEALDYHRQALVLIPQNASTYSAIGYIHSLMG 493
           ++  ++  D +     NLG V   LK++  A   +R A+    +    Y  +G +++ + 
Sbjct: 540 SLAVQIQPD-FAAAWMNLGIVQNSLKRFEAAEQSYRTAIKHRRKYPDCYYNLGRLYADLN 598

Query: 494 NFENAVDYFHTALGLRRDDTFS 515
              +A++ +  A  L+ + + +
Sbjct: 599 RHVDALNAWRNATVLKPEHSLA 620


>gi|118766330 transmembrane and tetratricopeptide repeat containing
           4 isoform 1 [Homo sapiens]
          Length = 760

 Score = 43.1 bits (100), Expect = 8e-04
 Identities = 29/123 (23%), Positives = 57/123 (46%), Gaps = 9/123 (7%)

Query: 388 ERFFSQALSIAPEDPFVMHEVGVVAFQNGEWKTAEKWFLDALEKIKAIGNEVTVDKWEPL 447
           E+ F  ALS+ P +  V + +G      G    A +++ +A+             K+   
Sbjct: 487 EQLFRSALSVCPLNAKVHYNIGKNLADKGNQTAAIRYYREAVR---------LNPKYVHA 537

Query: 448 LNNLGHVCRKLKKYAEALDYHRQALVLIPQNASTYSAIGYIHSLMGNFENAVDYFHTALG 507
           +NNLG++ ++  +  EA +    A+ + P  A+ +  +G + + +  FE A   + TA+ 
Sbjct: 538 MNNLGNILKERNELQEAEELLSLAVQIQPDFAAAWMNLGIVQNSLKRFEAAEQSYRTAIK 597

Query: 508 LRR 510
            RR
Sbjct: 598 HRR 600



 Score = 37.0 bits (84), Expect = 0.054
 Identities = 37/154 (24%), Positives = 64/154 (41%), Gaps = 4/154 (2%)

Query: 277 ELNKANELFYLSHKLVDLYPSNPVSWFAVGCYYLMVGHKNEHARRYLSKATTLEKTYGPA 336
           EL +A EL  L+   V + P    +W  +G     +  + E A +    A    + Y   
Sbjct: 550 ELQEAEELLSLA---VQIQPDFAAAWMNLGIVQNSL-KRFEAAEQSYRTAIKHRRKYPDC 605

Query: 337 WIAYGHSFAVESEHDQAMAAYFTAAQLMKGCHLPMLYIGLEYGLTNNSKLAERFFSQALS 396
           +   G  +A  + H  A+ A+  A  L     L    + +    T N   AE    +AL 
Sbjct: 606 YYNLGRLYADLNRHVDALNAWRNATVLKPEHSLAWNNMIILLDNTGNLAQAEAVGREALE 665

Query: 397 IAPEDPFVMHEVGVVAFQNGEWKTAEKWFLDALE 430
           + P D  +M  +  V  ++ ++K +E  FL A++
Sbjct: 666 LIPNDHSLMFSLANVLGKSQKYKESEALFLKAIK 699



 Score = 30.0 bits (66), Expect = 6.6
 Identities = 27/142 (19%), Positives = 63/142 (44%), Gaps = 9/142 (6%)

Query: 374 IGLEYGLTNNSKLAERFFSQALSIAPEDPFVMHEVGVVAFQNGEWKTAEKWFLDALEKIK 433
           IG       N   A R++ +A+ + P+    M+ +G +  +  E + AE+        + 
Sbjct: 507 IGKNLADKGNQTAAIRYYREAVRLNPKYVHAMNNLGNILKERNELQEAEE--------LL 558

Query: 434 AIGNEVTVDKWEPLLNNLGHVCRKLKKYAEALDYHRQALVLIPQNASTYSAIGYIHSLMG 493
           ++  ++  D +     NLG V   LK++  A   +R A+    +    Y  +G +++ + 
Sbjct: 559 SLAVQIQPD-FAAAWMNLGIVQNSLKRFEAAEQSYRTAIKHRRKYPDCYYNLGRLYADLN 617

Query: 494 NFENAVDYFHTALGLRRDDTFS 515
              +A++ +  A  L+ + + +
Sbjct: 618 RHVDALNAWRNATVLKPEHSLA 639


>gi|34304360 nephrocystin 3 [Homo sapiens]
          Length = 1330

 Score = 40.8 bits (94), Expect = 0.004
 Identities = 53/232 (22%), Positives = 99/232 (42%), Gaps = 24/232 (10%)

Query: 399  PEDPFVMHEVGVVAFQNGEWKTAEKWFLDALEKIKAIGNEVTVDKWEPLLNNLGHVCRKL 458
            P++   ++E+GV+ +     +TA+++   +LE  + +      D  + L NNL  +C + 
Sbjct: 1090 PDNARTLNELGVLYYLQNNLETADQFLKRSLEMRERVLGPDHPDCAQSL-NNLAALCNEK 1148

Query: 459  KK-------YAEALDYHRQALVL-IPQNASTYSAIGYIHSLMGNFENAVDYFHTALGLRR 510
            K+       Y  ALD  R+AL    P  A T   +  ++  MG  + AV  +  A+ +R+
Sbjct: 1149 KQYDKAEELYERALDIRRRALAPDHPSLAYTVKHLAILYKKMGKLDKAVPLYELAVEIRQ 1208

Query: 511  DD-----TFSVTMLGHCIEMYIGDSEAYIGADIKDK-LKCYDFDVHTM-----KTLKNII 559
                       T L +   +Y    +      + ++ LK Y+  +  M     +TLKN+ 
Sbjct: 1209 KSFGPKHPSVATALVNLAVLYSQMKKHVEALPLYERALKIYEDSLGRMHPRVGETLKNLA 1268

Query: 560  SPPWDFREFEVEKQTAEET-GLTPLETS---RKTPDSRPSLEETFEIEMNES 607
               ++  +FE   +  +    +   ETS    K P    S  +TF ++   S
Sbjct: 1269 VLSYEGGDFEKAAELYKRAMEIKEAETSLLGGKAPSRHSSSGDTFSLKTAHS 1320


>gi|28558993 intraflagellar transport 88 homolog isoform 1 [Homo
           sapiens]
          Length = 833

 Score = 40.0 bits (92), Expect = 0.006
 Identities = 48/275 (17%), Positives = 106/275 (38%), Gaps = 17/275 (6%)

Query: 232 DVVVSLAERHYYNCDFKMCYKLTSVVMEKDPFHASCLPVHIGTLVELNKANELFYLSHKL 291
           D+ ++ A  +    D+    ++  V+ +KD    S    ++  L  + K    F  +   
Sbjct: 425 DLEINKAVTYLRQKDYNQAVEILKVLEKKDSRVKSAAATNLSALYYMGKD---FAQASSY 481

Query: 292 VDLYPS----NPVSWFAVGCYYLMVGHKNEHARRYLSKATTLEKTYGPAWIAYGHSFAVE 347
            D+  +    NP +    G      G   E A  +  +A   + +   A    G ++   
Sbjct: 482 ADIAVNSDRYNPAALTNKGNTVFANGDY-EKAAEFYKEALRNDSSCTEALYNIGLTYEKL 540

Query: 348 SEHDQAMAAYFTAAQLMKGCHLPMLYIGLEYGLTNNSKLAERFFSQALSIAPEDPFVMHE 407
           +  D+A+  +     +++     +  I   Y L  N   A  +  Q +S+ P DP V+ +
Sbjct: 541 NRLDEALDCFLKLHAILRNSAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTDPQVLSK 600

Query: 408 VGVVAFQNGEWKTAEKWFLDALEKIKAIGNEVTVDKWEPLLNNLGHVCRKLKKYAEALDY 467
           +G +  + G+   A +++ ++          + V +W      LG      + + +A+ Y
Sbjct: 601 LGELYDREGDKSQAFQYYYESYRYFPC---NIEVIEW------LGAYYIDTQFWEKAIQY 651

Query: 468 HRQALVLIPQNASTYSAIGYIHSLMGNFENAVDYF 502
             +A ++ P        +       GN++ A+D +
Sbjct: 652 FERASLIQPTQVKWQLMVASCFRRSGNYQKALDTY 686



 Score = 38.1 bits (87), Expect = 0.024
 Identities = 29/133 (21%), Positives = 56/133 (42%), Gaps = 9/133 (6%)

Query: 401 DPFVMHEVGVVAFQNGEWKTAEKWFLDALEKIKAIGNEVTVDKWEPLLNNLGHVCRKLKK 460
           +P  +   G   F NG+++ A +++ +AL    +             L N+G    KL +
Sbjct: 492 NPAALTNKGNTVFANGDYEKAAEFYKEALRNDSSCTEA---------LYNIGLTYEKLNR 542

Query: 461 YAEALDYHRQALVLIPQNASTYSAIGYIHSLMGNFENAVDYFHTALGLRRDDTFSVTMLG 520
             EALD   +   ++  +A     I  I+ LM N   A+++    + +   D   ++ LG
Sbjct: 543 LDEALDCFLKLHAILRNSAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTDPQVLSKLG 602

Query: 521 HCIEMYIGDSEAY 533
              +     S+A+
Sbjct: 603 ELYDREGDKSQAF 615


>gi|28329439 intraflagellar transport 88 homolog isoform 2 [Homo
           sapiens]
          Length = 824

 Score = 40.0 bits (92), Expect = 0.006
 Identities = 48/275 (17%), Positives = 106/275 (38%), Gaps = 17/275 (6%)

Query: 232 DVVVSLAERHYYNCDFKMCYKLTSVVMEKDPFHASCLPVHIGTLVELNKANELFYLSHKL 291
           D+ ++ A  +    D+    ++  V+ +KD    S    ++  L  + K    F  +   
Sbjct: 416 DLEINKAVTYLRQKDYNQAVEILKVLEKKDSRVKSAAATNLSALYYMGKD---FAQASSY 472

Query: 292 VDLYPS----NPVSWFAVGCYYLMVGHKNEHARRYLSKATTLEKTYGPAWIAYGHSFAVE 347
            D+  +    NP +    G      G   E A  +  +A   + +   A    G ++   
Sbjct: 473 ADIAVNSDRYNPAALTNKGNTVFANGDY-EKAAEFYKEALRNDSSCTEALYNIGLTYEKL 531

Query: 348 SEHDQAMAAYFTAAQLMKGCHLPMLYIGLEYGLTNNSKLAERFFSQALSIAPEDPFVMHE 407
           +  D+A+  +     +++     +  I   Y L  N   A  +  Q +S+ P DP V+ +
Sbjct: 532 NRLDEALDCFLKLHAILRNSAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTDPQVLSK 591

Query: 408 VGVVAFQNGEWKTAEKWFLDALEKIKAIGNEVTVDKWEPLLNNLGHVCRKLKKYAEALDY 467
           +G +  + G+   A +++ ++          + V +W      LG      + + +A+ Y
Sbjct: 592 LGELYDREGDKSQAFQYYYESYRYFPC---NIEVIEW------LGAYYIDTQFWEKAIQY 642

Query: 468 HRQALVLIPQNASTYSAIGYIHSLMGNFENAVDYF 502
             +A ++ P        +       GN++ A+D +
Sbjct: 643 FERASLIQPTQVKWQLMVASCFRRSGNYQKALDTY 677



 Score = 38.1 bits (87), Expect = 0.024
 Identities = 29/133 (21%), Positives = 56/133 (42%), Gaps = 9/133 (6%)

Query: 401 DPFVMHEVGVVAFQNGEWKTAEKWFLDALEKIKAIGNEVTVDKWEPLLNNLGHVCRKLKK 460
           +P  +   G   F NG+++ A +++ +AL    +             L N+G    KL +
Sbjct: 483 NPAALTNKGNTVFANGDYEKAAEFYKEALRNDSSCTEA---------LYNIGLTYEKLNR 533

Query: 461 YAEALDYHRQALVLIPQNASTYSAIGYIHSLMGNFENAVDYFHTALGLRRDDTFSVTMLG 520
             EALD   +   ++  +A     I  I+ LM N   A+++    + +   D   ++ LG
Sbjct: 534 LDEALDCFLKLHAILRNSAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTDPQVLSKLG 593

Query: 521 HCIEMYIGDSEAY 533
              +     S+A+
Sbjct: 594 ELYDREGDKSQAF 606


>gi|224028289 tetratricopeptide repeat domain 28 [Homo sapiens]
          Length = 2481

 Score = 39.7 bits (91), Expect = 0.008
 Identities = 22/70 (31%), Positives = 33/70 (47%), Gaps = 6/70 (8%)

Query: 448 LNNLGHVCRKLKKYAEALDYHRQALVLIPQ------NASTYSAIGYIHSLMGNFENAVDY 501
           L+NLG+      +Y +A  Y+ Q L L P              +GY H  +GN++ AV Y
Sbjct: 597 LSNLGNFHCSRGEYVQAAPYYEQYLRLAPDLQDMEGEGKVCHNLGYAHYCLGNYQEAVKY 656

Query: 502 FHTALGLRRD 511
           +   L L +D
Sbjct: 657 YEQDLALAKD 666



 Score = 39.3 bits (90), Expect = 0.011
 Identities = 23/70 (32%), Positives = 36/70 (51%), Gaps = 6/70 (8%)

Query: 448 LNNLGHVCRKLKKYAEALDYHRQALVLIPQNASTYSA------IGYIHSLMGNFENAVDY 501
           L++LGHV   +  Y  AL  H+Q ++L  Q+    S       +G ++  MG+FENAV  
Sbjct: 317 LSSLGHVYTAIGDYPNALASHKQCVLLAKQSKDELSEARELGNMGAVYIAMGDFENAVQC 376

Query: 502 FHTALGLRRD 511
               L + +D
Sbjct: 377 HEQHLKIAKD 386



 Score = 38.9 bits (89), Expect = 0.014
 Identities = 47/216 (21%), Positives = 89/216 (41%), Gaps = 32/216 (14%)

Query: 312 VGHKNEHARRY--LSKATTLEKTYGPAWIAYGHSFAVESEHDQAMAAYFTAAQLMKGCHL 369
           +G+K E AR Y  L  A    + +  A ++Y H++ +E            A +LM+    
Sbjct: 387 LGNKREEARAYSNLGSAYHYRRNFDKA-MSY-HNYVLE-----------LAQELMEKAIE 433

Query: 370 PMLYIGLEYGLTNNSKL--AERFFSQALSIAPE------DPFVMHEVGVVAFQNGEWKTA 421
              Y GL +       L  A+++  Q L IA +      +      +G++    G++ TA
Sbjct: 434 MRAYAGLGHAARCMQDLERAKQYHEQQLGIAEDLKDRAAEGRASSNLGIIHQMKGDYDTA 493

Query: 422 EKWFLDALEKIKAIGNEVTVDKWEPLLNNLGHVCRKLKKYAEALDYHRQALVLIPQ---- 477
            K     L   + + +     +      N+G+    L  Y +A+ YHRQ L +  +    
Sbjct: 494 LKLHKTHLCIAQELSDYAAQGR---AYGNMGNAYNALGMYDQAVKYHRQELQISMEVNDR 550

Query: 478 --NASTYSAIGYIHSLMGNFENAVDYFHTALGLRRD 511
              AST+  +   +  +G  + A+ ++   L + R+
Sbjct: 551 ASQASTHGNLAVAYQALGAHDRALQHYQNHLNIARE 586



 Score = 38.1 bits (87), Expect = 0.024
 Identities = 40/169 (23%), Positives = 65/169 (38%), Gaps = 13/169 (7%)

Query: 350 HDQAMAAYFTAAQLMKGC----HLPMLYIGL-EYGLTNNSKLAERFFSQALSIAPEDPFV 404
           H Q +  Y   + L   C    HL  +Y+ L +Y +       +    Q L     +  V
Sbjct: 777 HTQELEVYQELSDLPGECRAHGHLAAVYMALGKYTMAFKCYEEQLDLGQKLKDPSLEAQV 836

Query: 405 MHEVGVVAFQNGEWKTAEKWFLDALEKIKAI-GNEVTVDKWEPLLNNLGHVCRKLKKYAE 463
              +G+        + A  +F   L  ++ + GNE  +D+      NLG     L  Y E
Sbjct: 837 YGNMGITKMNMNVMEEAIGYFEQQLAMLQQLSGNESVLDRGRAY-GNLGDCYEALGDYEE 895

Query: 464 ALDYHRQALVL------IPQNASTYSAIGYIHSLMGNFENAVDYFHTAL 506
           A+ Y+ Q L +      +   A  Y  +G  H  MG+ + A+  F   L
Sbjct: 896 AIKYYEQYLSVAQSLNRMQDQAKAYRGLGNGHRAMGSLQQALVCFEKRL 944



 Score = 34.7 bits (78), Expect = 0.27
 Identities = 29/117 (24%), Positives = 53/117 (45%), Gaps = 15/117 (12%)

Query: 450 NLGHVCRKLKKYAEALDYHRQALVLIPQ------NASTYSAIGYIHSLMGNFENAVDYFH 503
           NLG        Y EAL  HR  LVL  +       +S  S++G++++ +G++ NA+    
Sbjct: 279 NLGSAFFSKGNYREALTNHRHQLVLAMKLKDREAASSALSSLGHVYTAIGDYPNALASHK 338

Query: 504 TALGL---RRDDTFSVTMLGHCIEMYIGDSEAYIGADIKDKLKCYDFDVHTMKTLKN 557
             + L    +D+      LG+   +YI         D ++ ++C++  +   K L N
Sbjct: 339 QCVLLAKQSKDELSEARELGNMGAVYIA------MGDFENAVQCHEQHLKIAKDLGN 389



 Score = 31.6 bits (70), Expect = 2.3
 Identities = 21/64 (32%), Positives = 31/64 (48%), Gaps = 1/64 (1%)

Query: 449 NNLGHVCRKLKKYAEALDYHRQALVLIPQNASTYSAIGYIHSLMGNFENAVDYFHTALGL 508
           +NLG + +    Y  AL  H+  L  I Q  S Y+A G  +  MGN  NA+  +  A+  
Sbjct: 478 SNLGIIHQMKGDYDTALKLHKTHLC-IAQELSDYAAQGRAYGNMGNAYNALGMYDQAVKY 536

Query: 509 RRDD 512
            R +
Sbjct: 537 HRQE 540


>gi|229577238 tetratricopeptide repeat domain 18 [Homo sapiens]
          Length = 1121

 Score = 37.4 bits (85), Expect = 0.041
 Identities = 42/195 (21%), Positives = 76/195 (38%), Gaps = 19/195 (9%)

Query: 308  YYLMVGHKN------EHARRYLSKATTLEKTYGPAWIAYGHSFAVESEHDQAMAAYFTAA 361
            YYL++   +        A  YL +A  ++      W   GH + +   H +A A Y    
Sbjct: 931  YYLVLAQTHILKKNFAKAEEYLQQAAQMDYLNPNVWGLKGHLYFLSGNHSEAKACYERTI 990

Query: 362  QLM---KGCHLPMLYIGLEYGLTNNSKLAERFFSQALSIAPEDPFVMHEVGVVAFQNGEW 418
              +      H   L +GL Y      + A++ + QA   +P        +G+  ++  E 
Sbjct: 991  SFVVDASEMHFIFLRLGLIYLEEKEYEKAKKTYMQACKRSP-SCLTWLGLGIACYRLEEL 1049

Query: 419  KTAEKWFLDALEKIKAIGNEVTVDKWEPLLNNLGHVCRKLKKYAEALDYHRQALVLIPQN 478
              AE    DAL +  A+ N    + W      L  VC K+ +  EA   ++  + L  ++
Sbjct: 1050 TEAE----DALSEANAL-NNYNAEVWA----YLALVCLKVGRQLEAEQAYKYMIKLKLKD 1100

Query: 479  ASTYSAIGYIHSLMG 493
             +  + I  +   +G
Sbjct: 1101 EALLAEIHTLQETVG 1115


>gi|116534937 interferon-induced protein with tetratricopeptide
           repeats 1 isoform 2 [Homo sapiens]
          Length = 478

 Score = 37.4 bits (85), Expect = 0.041
 Identities = 41/151 (27%), Positives = 65/151 (43%), Gaps = 21/151 (13%)

Query: 368 HLPMLYIGLEYGLTNNSKLAERFFSQALSIAPEDPFVMHEVGVV--AFQNGEWKTAEKWF 425
           HL +  + +E G   N + AE  F + L + P     M ++      FQ  + K+     
Sbjct: 343 HLDLARMYIEAG---NHRKAEENFQKLLCMKPVVEETMQDIHFHYGRFQEFQKKSDVNAI 399

Query: 426 LDALEKIKAIGNEVTVDKWEPLLNNLGHVCRKLKKYAEALDYHRQALVLIPQNASTYSAI 485
           +  L+ IK     +T DK    L  L  V RKL++ A  L+              + S +
Sbjct: 400 IHYLKAIKIEQASLTRDKSINSLKKL--VLRKLRRKALDLE--------------SLSLL 443

Query: 486 GYIHSLMGNFENAVDYFHTALGLRRDDTFSV 516
           G+++ L GN   A++Y+  AL L  D   SV
Sbjct: 444 GFVYKLEGNMNEALEYYERALRLAADFENSV 474


>gi|25952122 Bardet-Biedl syndrome 4 [Homo sapiens]
          Length = 519

 Score = 37.4 bits (85), Expect = 0.041
 Identities = 44/205 (21%), Positives = 82/205 (40%), Gaps = 11/205 (5%)

Query: 305 VGCYYLMVGHKNEHARRYLSKATTLEKTYGPAWIAYGHSFAVESEHDQAMAAYFTAAQLM 364
           +G  Y+ +   N+ A+  L  A  L + +   +I  G    +E + D+A+  Y  A +  
Sbjct: 141 LGVCYIYLKQFNK-AQDQLHNALNLNR-HDLTYIMLGKIHLLEGDLDKAIEVYKKAVEFS 198

Query: 365 KGCHLPMLYIGLEYGLTNNSKLAERFFSQALSIAPEDPFVMHEVGVVAFQNGEWKTAEKW 424
                 +  +GL Y      + A      AL+  P +   +   G +   +G++  A   
Sbjct: 199 PENTELLTTLGLLYLQLGIYQKAFEHLGNALTYDPTNYKAILAAGSMMQTHGDFDVA--- 255

Query: 425 FLDALEKIKAIGNEVTVDKWEPLLNNLGHVCRKLKKYAEALDYHRQALVLIPQNASTYSA 484
               L K + +     V +  PL NN+G      KKY  A+   ++A  L P +      
Sbjct: 256 ----LTKYRVVA--CAVPESPPLWNNIGMCFFGKKKYVAAISCLKRANYLAPFDWKILYN 309

Query: 485 IGYIHSLMGNFENAVDYFHTALGLR 509
           +G +H  M  + +A  +   A+  +
Sbjct: 310 LGLVHLTMQQYASAFHFLSAAINFQ 334



 Score = 37.4 bits (85), Expect = 0.041
 Identities = 53/250 (21%), Positives = 94/250 (37%), Gaps = 49/250 (19%)

Query: 277 ELNKANELFYLSHKLVDLYPSNPVSWFAVGCYYLMVGHKNEHARRYLSKATTLEKTYGPA 336
           +L+KA E++    K V+  P N      +G  YL +G   + A  +L  A T + T   A
Sbjct: 183 DLDKAIEVY---KKAVEFSPENTELLTTLGLLYLQLGIYQK-AFEHLGNALTYDPTNYKA 238

Query: 337 WIAYGHSFAVESEHDQAMAAYFTAAQLMKGCHLPMLYIGLEYGLTNNSKLAERFFSQALS 396
            +A G       + D A+  Y   A                                   
Sbjct: 239 ILAAGSMMQTHGDFDVALTKYRVVA----------------------------------C 264

Query: 397 IAPEDPFVMHEVGVVAFQNGEWKTAEKWFLDALEKIKAIGNEVTVDKWEPLLNNLGHVCR 456
             PE P + + +G+  F        +K ++ A+  +K   N +    W+ +L NLG V  
Sbjct: 265 AVPESPPLWNNIGMCFF-------GKKKYVAAISCLKR-ANYLAPFDWK-ILYNLGLVHL 315

Query: 457 KLKKYAEALDYHRQALVLIPQNASTYSAIGYIHSLMGNFENAVDYFHTALGLRRDDTFSV 516
            +++YA A  +   A+   P+    Y  +    + + + ENA   +  A+ L  D    +
Sbjct: 316 TMQQYASAFHFLSAAINFQPKMGELYMLLAVALTNLEDIENAKRAYAEAVHL--DKCNPL 373

Query: 517 TMLGHCIEMY 526
             L + + +Y
Sbjct: 374 VNLNYAVLLY 383



 Score = 31.6 bits (70), Expect = 2.3
 Identities = 41/232 (17%), Positives = 103/232 (44%), Gaps = 17/232 (7%)

Query: 219 VIPESVDGLQENLDVVVSLAERHYYNCDFKMCYKLTSVVMEKDPFHASCLPVHIGTLVEL 278
           V  ++V+   EN +++ +L   +     ++  ++     +  DP +   + +  G++++ 
Sbjct: 190 VYKKAVEFSPENTELLTTLGLLYLQLGIYQKAFEHLGNALTYDPTNYKAI-LAAGSMMQT 248

Query: 279 NKANELFYLSHKLVDL-YPSNPVSWFAVG-CYYLMVGHKNEHARRYLSKATTLEKTYGPA 336
           +   ++    +++V    P +P  W  +G C++          ++Y++  + L++    A
Sbjct: 249 HGDFDVALTKYRVVACAVPESPPLWNNIGMCFF--------GKKKYVAAISCLKRANYLA 300

Query: 337 ---W-IAYGHSFAVESEHDQAMAAYFTAAQLMKGCHLPMLYIGLEYGLTNNSKL--AERF 390
              W I Y       +    A A +F +A +     +  LY+ L   LTN   +  A+R 
Sbjct: 301 PFDWKILYNLGLVHLTMQQYASAFHFLSAAINFQPKMGELYMLLAVALTNLEDIENAKRA 360

Query: 391 FSQALSIAPEDPFVMHEVGVVAFQNGEWKTAEKWFLDALEKIKAIGNEVTVD 442
           +++A+ +   +P V     V+ +  GE K A   + +  +K+  + +  +++
Sbjct: 361 YAEAVHLDKCNPLVNLNYAVLLYNQGEKKNALAQYQEMEKKVSLLKDNSSLE 412


>gi|22749211 transmembrane and tetratricopeptide repeat containing 2
           [Homo sapiens]
          Length = 836

 Score = 37.4 bits (85), Expect = 0.041
 Identities = 42/187 (22%), Positives = 74/187 (39%), Gaps = 17/187 (9%)

Query: 336 AWIAYGHSFAVESEHDQAMAAYFTAAQLMKGCHLPMLYIGLEYGLTNNSKLAE--RFFSQ 393
           AW   G+    +S+  +A +AY  A          +  +GL   L  NS+ AE   ++  
Sbjct: 495 AWGNLGNVLKSQSKISEAESAYRNALYYRSNMADMLYNLGLL--LQENSRFAEALHYYKL 552

Query: 394 ALSIAPEDPFVMHEVGVVAFQNGEWKTAEKWFLDALEKIKAIGNEVTVDKWE------PL 447
           A+   P         G++    G  + A + FL    K   I +E   D           
Sbjct: 553 AIGSRPTLASAYLNTGIILMNQGRTEEARRTFL----KCSEIPDENLKDPHAHKSSVTSC 608

Query: 448 LNNLGHVCRKLKKYAEALDYHRQALVLIPQN---ASTYSAIGYIHSLMGNFENAVDYFHT 504
           L NLG +  +   Y EAL  +++A+  +P+     S Y+ +G  +  +     A  ++  
Sbjct: 609 LYNLGKLYHEQGHYEEALSVYKEAIQKMPRQFAPQSLYNMMGEAYMRLSKLPEAEHWYME 668

Query: 505 ALGLRRD 511
           +L  + D
Sbjct: 669 SLRSKTD 675



 Score = 36.6 bits (83), Expect = 0.071
 Identities = 29/120 (24%), Positives = 53/120 (44%), Gaps = 1/120 (0%)

Query: 311 MVGHKNEHARRYLSKATTLEKTYGPAWIAYGHSFAVESEHDQAMAAYFTAAQLMKGCHLP 370
           + G K+E  + +L KA  L+ T G  ++ YG     E+   +A      AA+L       
Sbjct: 689 LTGRKSEAEKLFL-KAIELDPTKGNCYMHYGQFLLEEARLIEAAEMAKKAAELDSTEFDV 747

Query: 371 MLYIGLEYGLTNNSKLAERFFSQALSIAPEDPFVMHEVGVVAFQNGEWKTAEKWFLDALE 430
           +          + ++ AE+++  A  + P  P  +  +G +   NG  + AE  +L AL+
Sbjct: 748 VFNAAHMLRQASLNEAAEKYYDLAARLRPNYPAALMNLGAILHLNGRLQKAEANYLRALQ 807



 Score = 35.4 bits (80), Expect = 0.16
 Identities = 35/137 (25%), Positives = 56/137 (40%), Gaps = 24/137 (17%)

Query: 385 KLAERFFSQALSIAPEDPFVMHEVGVVAFQNGEWKTAEKWFLDALE--KIKAIGNEVTVD 442
           K+ +RF    +  A     V + +   A +NG+W+  E  +   ++    KA GN   V 
Sbjct: 445 KVQKRFLKSLIFYATATLIVFYGLKT-AIRNGDWQNEEMLYRSGIKVNPAKAWGNLGNVL 503

Query: 443 KWEP---------------------LLNNLGHVCRKLKKYAEALDYHRQALVLIPQNAST 481
           K +                      +L NLG + ++  ++AEAL Y++ A+   P  AS 
Sbjct: 504 KSQSKISEAESAYRNALYYRSNMADMLYNLGLLLQENSRFAEALHYYKLAIGSRPTLASA 563

Query: 482 YSAIGYIHSLMGNFENA 498
           Y   G I    G  E A
Sbjct: 564 YLNTGIILMNQGRTEEA 580


>gi|110225358 tetratricopeptide repeat domain 7A [Homo sapiens]
          Length = 858

 Score = 37.4 bits (85), Expect = 0.041
 Identities = 26/105 (24%), Positives = 48/105 (45%), Gaps = 4/105 (3%)

Query: 327 TTLEKTYGPAWIAYGHSFAVESEHDQAMAAYFTAAQLMKGCHLPMLYIGLEYGLTNNSKL 386
           TTLE+     W+     F  +    +A      AA L    H  +   G    +  N + 
Sbjct: 708 TTLEQI----WLQAAELFMEQQHLKEAGFCIQEAAGLFPTSHSVLYMRGRLAEVKGNLEE 763

Query: 387 AERFFSQALSIAPEDPFVMHEVGVVAFQNGEWKTAEKWFLDALEK 431
           A++ + +AL++ P+   +MH +G++  + G    A+K   DA+E+
Sbjct: 764 AKQLYKEALTVNPDGVRIMHSLGLMLSRLGHKSLAQKVLRDAVER 808



 Score = 36.2 bits (82), Expect = 0.092
 Identities = 32/103 (31%), Positives = 47/103 (45%), Gaps = 4/103 (3%)

Query: 19  YQSALFWADKVASLSREEPQDIYWLAQCLYLTAQYHRAAHALRSR-KLDKLYEACRYLAA 77
           ++ AL   ++   L+  +PQ I +++  L L  Q   A   L+   K+ K      +L A
Sbjct: 514 HRKALQTLERAQQLAPSDPQVILYVSLQLALVRQISSAMEQLQEALKVRKDDAHALHLLA 573

Query: 78  RCHYAAKEHQQALDVLDM---EEPINKRLFEKYLKDESGFKDP 117
               A K HQ ALDV++M   E P N  L    +K E   K P
Sbjct: 574 LLFSAQKHHQHALDVVNMAITEHPENFNLMFTKVKLEQVLKGP 616


>gi|224548927 G-protein signaling modulator 1 (AGS3-like, C.
           elegans) isoform a [Homo sapiens]
          Length = 675

 Score = 36.6 bits (83), Expect = 0.071
 Identities = 23/96 (23%), Positives = 42/96 (43%), Gaps = 9/96 (9%)

Query: 421 AEKWFLDALEKIKAIGNEVTVDKWEPLLNNLGHVCRKLKKYAEALDYHRQALVLIPQ--- 477
           A +++   L  +K +G+     +      NLG+    L  + EA  +H++ L +  +   
Sbjct: 188 ASEFYERNLSLVKELGDRAAQGR---AYGNLGNTHYLLGNFTEATTFHKERLAIAKEFGD 244

Query: 478 ---NASTYSAIGYIHSLMGNFENAVDYFHTALGLRR 510
                  YS +G  H  +G F+ A +Y+   L L R
Sbjct: 245 KAAERRAYSNLGNAHVFLGRFDVAAEYYKKTLQLSR 280


>gi|224548925 G-protein signaling modulator 1 (AGS3-like, C.
           elegans) isoform b [Homo sapiens]
          Length = 457

 Score = 36.6 bits (83), Expect = 0.071
 Identities = 23/96 (23%), Positives = 42/96 (43%), Gaps = 9/96 (9%)

Query: 421 AEKWFLDALEKIKAIGNEVTVDKWEPLLNNLGHVCRKLKKYAEALDYHRQALVLIPQ--- 477
           A +++   L  +K +G+     +      NLG+    L  + EA  +H++ L +  +   
Sbjct: 188 ASEFYERNLSLVKELGDRAAQGR---AYGNLGNTHYLLGNFTEATTFHKERLAIAKEFGD 244

Query: 478 ---NASTYSAIGYIHSLMGNFENAVDYFHTALGLRR 510
                  YS +G  H  +G F+ A +Y+   L L R
Sbjct: 245 KAAERRAYSNLGNAHVFLGRFDVAAEYYKKTLQLSR 280


>gi|41871960 kinesin-like 8 isoform b [Homo sapiens]
          Length = 637

 Score = 35.4 bits (80), Expect = 0.16
 Identities = 35/111 (31%), Positives = 53/111 (47%), Gaps = 13/111 (11%)

Query: 374 IGLEYGLTNNSKLAERFFSQALSI-----APEDPFV---MHEVGVVAFQNGEWKTAEKWF 425
           + L Y   N  K A    + ALSI      P+ P V   ++ + V+  + G++K AE   
Sbjct: 277 LALVYRDQNKYKEAAHLLNDALSIRESTLGPDHPAVAATLNNLAVLYGKRGKYKEAEPLC 336

Query: 426 LDALE-KIKAIG-NEVTVDKWEPLLNNLGHVCRKLKKYAEALDYHRQALVL 474
             ALE + K +G N   V K    LNNL  +C+   KY     Y+++AL +
Sbjct: 337 QRALEIREKVLGTNHPDVAKQ---LNNLALLCQNQGKYEAVERYYQRALAI 384


>gi|41871955 kinesin-like 8 isoform a [Homo sapiens]
          Length = 619

 Score = 35.4 bits (80), Expect = 0.16
 Identities = 35/111 (31%), Positives = 53/111 (47%), Gaps = 13/111 (11%)

Query: 374 IGLEYGLTNNSKLAERFFSQALSI-----APEDPFV---MHEVGVVAFQNGEWKTAEKWF 425
           + L Y   N  K A    + ALSI      P+ P V   ++ + V+  + G++K AE   
Sbjct: 259 LALVYRDQNKYKEAAHLLNDALSIRESTLGPDHPAVAATLNNLAVLYGKRGKYKEAEPLC 318

Query: 426 LDALE-KIKAIG-NEVTVDKWEPLLNNLGHVCRKLKKYAEALDYHRQALVL 474
             ALE + K +G N   V K    LNNL  +C+   KY     Y+++AL +
Sbjct: 319 QRALEIREKVLGTNHPDVAKQ---LNNLALLCQNQGKYEAVERYYQRALAI 366


>gi|41871946 kinesin-like 8 isoform a [Homo sapiens]
          Length = 619

 Score = 35.4 bits (80), Expect = 0.16
 Identities = 35/111 (31%), Positives = 53/111 (47%), Gaps = 13/111 (11%)

Query: 374 IGLEYGLTNNSKLAERFFSQALSI-----APEDPFV---MHEVGVVAFQNGEWKTAEKWF 425
           + L Y   N  K A    + ALSI      P+ P V   ++ + V+  + G++K AE   
Sbjct: 259 LALVYRDQNKYKEAAHLLNDALSIRESTLGPDHPAVAATLNNLAVLYGKRGKYKEAEPLC 318

Query: 426 LDALE-KIKAIG-NEVTVDKWEPLLNNLGHVCRKLKKYAEALDYHRQALVL 474
             ALE + K +G N   V K    LNNL  +C+   KY     Y+++AL +
Sbjct: 319 QRALEIREKVLGTNHPDVAKQ---LNNLALLCQNQGKYEAVERYYQRALAI 366


>gi|60685231 tetratricopeptide repeat domain 7B [Homo sapiens]
          Length = 843

 Score = 35.4 bits (80), Expect = 0.16
 Identities = 36/143 (25%), Positives = 58/143 (40%), Gaps = 9/143 (6%)

Query: 332 TYGPAWIAYGHSFAVESEHDQAMAAYFTAAQLMKGCHLPMLYIGLEYGLTNNSKLAERFF 391
           T    W+     +    +  +A A    AA L    H  +   G    L  +   A R++
Sbjct: 694 TLAQIWLHAAEVYIGIGKPAEATACTQEAANLFPMSHNVLYMRGQIAELRGSMDEARRWY 753

Query: 392 SQALSIAPEDPFVMHEVGVVAFQNGEWKTAEKWFLDALEKIKAIGNEVTVDKWEPLLNNL 451
            +AL+I+P     M  + ++  Q G +  AEK   DA++ + +  +EV    W    N L
Sbjct: 754 EEALAISPTHVKSMQRLALILHQLGRYSLAEKILRDAVQ-VNSTAHEV----W----NGL 804

Query: 452 GHVCRKLKKYAEALDYHRQALVL 474
           G V +     A A +    AL L
Sbjct: 805 GEVLQAQGNDAAATECFLTALEL 827


>gi|53759120 tetratricopeptide repeat domain 8 isoform A [Homo
           sapiens]
          Length = 515

 Score = 33.9 bits (76), Expect = 0.46
 Identities = 42/182 (23%), Positives = 72/182 (39%), Gaps = 8/182 (4%)

Query: 329 LEKTYGPAWIAYGHSFAVESEHDQAMAA-YFTAAQLMKGCHLPMLY-IGLEYGLTNNSKL 386
           L+K  G   +  G +   E  ++ + AA Y+         H+  +  IG  +  ++  ++
Sbjct: 285 LDKFPGEVTLLCGIARIYEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFYSDQPEI 344

Query: 387 AERFFSQALSIAPEDPFVMHEVGVVAFQNGEWKTAEKWFLDALEKIKAIGNEVTVDKWEP 446
           A RF+ + L +   +  + + +G+  F   ++      F  AL    A   E   D W  
Sbjct: 345 ALRFYRRLLQMGIYNGQLFNNLGLCCFYAQQYDMTLTSFERALSL--AENEEEAADVWY- 401

Query: 447 LLNNLGHVCRKLKKYAEALDYHRQALVLIPQNASTYSAIGYIHSLMGNFENAVDYFHTAL 506
              NLGHV   +     A    R ALV    +A  Y+ +  +    G+ E A     TA 
Sbjct: 402 ---NLGHVAVGIGDTNLAHQCFRLALVNNNNHAEAYNNLAVLEMRKGHVEQARALLQTAS 458

Query: 507 GL 508
            L
Sbjct: 459 SL 460



 Score = 33.1 bits (74), Expect = 0.78
 Identities = 50/201 (24%), Positives = 78/201 (38%), Gaps = 52/201 (25%)

Query: 1   MNLERLRKRVRQYLDQQQYQSALF-----------WADKVASLSREEPQ--DIYWLAQ-- 45
           +NL RL   + +Y  + +   ALF            A  +A+LS E  Q  D +W  Q  
Sbjct: 175 INLSRLN--LTKYSQKPKLAKALFEYIFHHENDVKTALDLAALSTEHSQYKDWWWKVQIG 232

Query: 46  -CLYLTAQYHRAAHALRSR-KLDKLYEACRYLAARCHYAAKEHQQALDVLDMEEPINK-R 102
            C Y    Y  A    +S  K  ++ +   YLA                + +++P+    
Sbjct: 233 KCYYRLGMYREAEKQFKSALKQQEMVDTFLYLAKV-------------YVSLDQPVTALN 279

Query: 103 LFEKYLKDESGFKDPSSDWEMSQSSIKSSICLLRG--KIYDALDNRTLATYSYKEALKLD 160
           LF++ L    G                  + LL G  +IY+ ++N + A   YKE LK D
Sbjct: 280 LFKQGLDKFPG-----------------EVTLLCGIARIYEEMNNMSSAAEYYKEVLKQD 322

Query: 161 VYCFEAFDLLTSHHMLTAQEE 181
               EA   + S+H  + Q E
Sbjct: 323 NTHVEAIACIGSNHFYSDQPE 343



 Score = 31.6 bits (70), Expect = 2.3
 Identities = 25/107 (23%), Positives = 48/107 (44%), Gaps = 12/107 (11%)

Query: 407 EVGVVAFQNGEWKTAEKWFLDALEKIKAIGNEVTVDKWEPLLNNLGHVCRKLKKYAEALD 466
           ++G   ++ G ++ AEK F  AL++ + +   + + K          V   L +   AL+
Sbjct: 230 QIGKCYYRLGMYREAEKQFKSALKQQEMVDTFLYLAK----------VYVSLDQPVTALN 279

Query: 467 YHRQALVLIPQNASTYSAIGYIHSLMGNFENAVDYFHTALGLRRDDT 513
             +Q L   P   +    I  I+  M N  +A +Y+     L++D+T
Sbjct: 280 LFKQGLDKFPGEVTLLCGIARIYEEMNNMSSAAEYYKEV--LKQDNT 324


>gi|38146008 tetratricopeptide repeat domain 8 isoform C [Homo
           sapiens]
          Length = 475

 Score = 33.9 bits (76), Expect = 0.46
 Identities = 42/182 (23%), Positives = 72/182 (39%), Gaps = 8/182 (4%)

Query: 329 LEKTYGPAWIAYGHSFAVESEHDQAMAA-YFTAAQLMKGCHLPMLY-IGLEYGLTNNSKL 386
           L+K  G   +  G +   E  ++ + AA Y+         H+  +  IG  +  ++  ++
Sbjct: 245 LDKFPGEVTLLCGIARIYEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFYSDQPEI 304

Query: 387 AERFFSQALSIAPEDPFVMHEVGVVAFQNGEWKTAEKWFLDALEKIKAIGNEVTVDKWEP 446
           A RF+ + L +   +  + + +G+  F   ++      F  AL    A   E   D W  
Sbjct: 305 ALRFYRRLLQMGIYNGQLFNNLGLCCFYAQQYDMTLTSFERALSL--AENEEEAADVWY- 361

Query: 447 LLNNLGHVCRKLKKYAEALDYHRQALVLIPQNASTYSAIGYIHSLMGNFENAVDYFHTAL 506
              NLGHV   +     A    R ALV    +A  Y+ +  +    G+ E A     TA 
Sbjct: 362 ---NLGHVAVGIGDTNLAHQCFRLALVNNNNHAEAYNNLAVLEMRKGHVEQARALLQTAS 418

Query: 507 GL 508
            L
Sbjct: 419 SL 420



 Score = 32.7 bits (73), Expect = 1.0
 Identities = 41/162 (25%), Positives = 64/162 (39%), Gaps = 39/162 (24%)

Query: 29  VASLSREEPQ--DIYWLAQ---CLYLTAQYHRAAHALRSR-KLDKLYEACRYLAARCHYA 82
           +A+LS E  Q  D +W  Q   C Y    Y  A    +S  K  ++ +   YLA      
Sbjct: 172 LAALSTEHSQYKDWWWKVQIGKCYYRLGMYREAEKQFKSALKQQEMVDTFLYLAKV---- 227

Query: 83  AKEHQQALDVLDMEEPINK-RLFEKYLKDESGFKDPSSDWEMSQSSIKSSICLLRG--KI 139
                     + +++P+    LF++ L    G                  + LL G  +I
Sbjct: 228 ---------YVSLDQPVTALNLFKQGLDKFPG-----------------EVTLLCGIARI 261

Query: 140 YDALDNRTLATYSYKEALKLDVYCFEAFDLLTSHHMLTAQEE 181
           Y+ ++N + A   YKE LK D    EA   + S+H  + Q E
Sbjct: 262 YEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFYSDQPE 303



 Score = 31.6 bits (70), Expect = 2.3
 Identities = 25/107 (23%), Positives = 48/107 (44%), Gaps = 12/107 (11%)

Query: 407 EVGVVAFQNGEWKTAEKWFLDALEKIKAIGNEVTVDKWEPLLNNLGHVCRKLKKYAEALD 466
           ++G   ++ G ++ AEK F  AL++ + +   + + K          V   L +   AL+
Sbjct: 190 QIGKCYYRLGMYREAEKQFKSALKQQEMVDTFLYLAK----------VYVSLDQPVTALN 239

Query: 467 YHRQALVLIPQNASTYSAIGYIHSLMGNFENAVDYFHTALGLRRDDT 513
             +Q L   P   +    I  I+  M N  +A +Y+     L++D+T
Sbjct: 240 LFKQGLDKFPGEVTLLCGIARIYEEMNNMSSAAEYYKEV--LKQDNT 284


>gi|38146012 tetratricopeptide repeat domain 8 isoform B [Homo
           sapiens]
          Length = 505

 Score = 33.9 bits (76), Expect = 0.46
 Identities = 42/182 (23%), Positives = 72/182 (39%), Gaps = 8/182 (4%)

Query: 329 LEKTYGPAWIAYGHSFAVESEHDQAMAA-YFTAAQLMKGCHLPMLY-IGLEYGLTNNSKL 386
           L+K  G   +  G +   E  ++ + AA Y+         H+  +  IG  +  ++  ++
Sbjct: 275 LDKFPGEVTLLCGIARIYEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFYSDQPEI 334

Query: 387 AERFFSQALSIAPEDPFVMHEVGVVAFQNGEWKTAEKWFLDALEKIKAIGNEVTVDKWEP 446
           A RF+ + L +   +  + + +G+  F   ++      F  AL    A   E   D W  
Sbjct: 335 ALRFYRRLLQMGIYNGQLFNNLGLCCFYAQQYDMTLTSFERALSL--AENEEEAADVWY- 391

Query: 447 LLNNLGHVCRKLKKYAEALDYHRQALVLIPQNASTYSAIGYIHSLMGNFENAVDYFHTAL 506
              NLGHV   +     A    R ALV    +A  Y+ +  +    G+ E A     TA 
Sbjct: 392 ---NLGHVAVGIGDTNLAHQCFRLALVNNNNHAEAYNNLAVLEMRKGHVEQARALLQTAS 448

Query: 507 GL 508
            L
Sbjct: 449 SL 450



 Score = 33.1 bits (74), Expect = 0.78
 Identities = 50/201 (24%), Positives = 78/201 (38%), Gaps = 52/201 (25%)

Query: 1   MNLERLRKRVRQYLDQQQYQSALF-----------WADKVASLSREEPQ--DIYWLAQ-- 45
           +NL RL   + +Y  + +   ALF            A  +A+LS E  Q  D +W  Q  
Sbjct: 165 INLSRLN--LTKYSQKPKLAKALFEYIFHHENDVKTALDLAALSTEHSQYKDWWWKVQIG 222

Query: 46  -CLYLTAQYHRAAHALRSR-KLDKLYEACRYLAARCHYAAKEHQQALDVLDMEEPINK-R 102
            C Y    Y  A    +S  K  ++ +   YLA                + +++P+    
Sbjct: 223 KCYYRLGMYREAEKQFKSALKQQEMVDTFLYLAKV-------------YVSLDQPVTALN 269

Query: 103 LFEKYLKDESGFKDPSSDWEMSQSSIKSSICLLRG--KIYDALDNRTLATYSYKEALKLD 160
           LF++ L    G                  + LL G  +IY+ ++N + A   YKE LK D
Sbjct: 270 LFKQGLDKFPG-----------------EVTLLCGIARIYEEMNNMSSAAEYYKEVLKQD 312

Query: 161 VYCFEAFDLLTSHHMLTAQEE 181
               EA   + S+H  + Q E
Sbjct: 313 NTHVEAIACIGSNHFYSDQPE 333



 Score = 31.6 bits (70), Expect = 2.3
 Identities = 25/107 (23%), Positives = 48/107 (44%), Gaps = 12/107 (11%)

Query: 407 EVGVVAFQNGEWKTAEKWFLDALEKIKAIGNEVTVDKWEPLLNNLGHVCRKLKKYAEALD 466
           ++G   ++ G ++ AEK F  AL++ + +   + + K          V   L +   AL+
Sbjct: 220 QIGKCYYRLGMYREAEKQFKSALKQQEMVDTFLYLAK----------VYVSLDQPVTALN 269

Query: 467 YHRQALVLIPQNASTYSAIGYIHSLMGNFENAVDYFHTALGLRRDDT 513
             +Q L   P   +    I  I+  M N  +A +Y+     L++D+T
Sbjct: 270 LFKQGLDKFPGEVTLLCGIARIYEEMNNMSSAAEYYKEV--LKQDNT 314


>gi|42475558 SMG-7 homolog isoform 1 [Homo sapiens]
          Length = 1137

 Score = 33.9 bits (76), Expect = 0.46
 Identities = 15/62 (24%), Positives = 32/62 (51%)

Query: 448 LNNLGHVCRKLKKYAEALDYHRQALVLIPQNASTYSAIGYIHSLMGNFENAVDYFHTALG 507
           L +LG + R   + ++A  Y+R A  L+P N   Y+ +  + S  G+    + Y+  ++ 
Sbjct: 155 LVHLGDIARYRNQTSQAESYYRHAAQLVPSNGQPYNQLAILASSKGDHLTTIFYYCRSIA 214

Query: 508 LR 509
           ++
Sbjct: 215 VK 216


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.133    0.399 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,418,465
Number of Sequences: 37866
Number of extensions: 953848
Number of successful extensions: 2945
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 41
Number of HSP's successfully gapped in prelim test: 26
Number of HSP's that attempted gapping in prelim test: 2756
Number of HSP's gapped (non-prelim): 186
length of query: 620
length of database: 18,247,518
effective HSP length: 108
effective length of query: 512
effective length of database: 14,157,990
effective search space: 7248890880
effective search space used: 7248890880
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.