Search of human proteins with 118150678

Search of human proteins with 118150678

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|118150678 epithelial cell transforming sequence 2
oncogene-like [Homo sapiens]
         (904 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|118150678 epithelial cell transforming sequence 2 oncogene-li...  1827   0.0  
gi|27312027 F-box only protein 16 [Homo sapiens]                      162   1e-39
gi|21735572 epithelial cell transforming sequence 2 oncogene pro...   110   5e-24
gi|224586880 Ras protein-specific guanine nucleotide-releasing f...    96   2e-19
gi|24797099 Ras protein-specific guanine nucleotide-releasing fa...    96   2e-19
gi|38505170 Ras protein-specific guanine nucleotide-releasing fa...    88   4e-17
gi|82546845 breakpoint cluster region isoform 2 [Homo sapiens]         86   2e-16
gi|82546843 breakpoint cluster region isoform 1 [Homo sapiens]         86   2e-16
gi|58761492 Rho guanine nucleotide exchange factor (GEF) 10-like...    84   5e-16
gi|74136547 Rho guanine nucleotide exchange factor (GEF) 10-like...    84   5e-16
gi|229094128 active breakpoint cluster region-related  protein i...    81   5e-15
gi|38679957 active breakpoint cluster region-related  protein is...    81   5e-15
gi|38679954 active breakpoint cluster region-related  protein is...    81   5e-15
gi|21361458 Rho guanine nucleotide exchange factor (GEF) 17 [Hom...    81   5e-15
gi|62548864 Rho guanine nucleotide exchange factor 10 [Homo sapi...    80   7e-15
gi|34452732 phosphatidylinositol-3,4,5-trisphosphate-dependent R...    78   3e-14
gi|198041928 FYVE, RhoGEF and PH domain containing 4 [Homo sapiens]    77   7e-14
gi|7662310 FERM, RhoGEF and pleckstrin domain protein 2 [Homo sa...    75   4e-13
gi|71274148 pleckstrin homology domain containing, family G (wit...    74   5e-13
gi|189217917 FYVE, RhoGEF and PH domain containing 2 [Homo sapiens]    72   2e-12
gi|24797153 faciogenital dysplasia protein [Homo sapiens]              66   2e-10
gi|114145479 neuroepithelial cell transforming gene 1 isoform 1 ...    65   2e-10
gi|19923327 neuroepithelial cell transforming gene 1 isoform 2 [...    65   2e-10
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]                65   4e-10
gi|120432044 vav 3 guanine nucleotide exchange factor isoform 1 ...    64   6e-10
gi|194294523 intersectin 2 isoform 3 [Homo sapiens]                    63   1e-09
gi|194294521 intersectin 2 isoform 1 [Homo sapiens]                    63   1e-09
gi|134133248 FYVE, RhoGEF and PH domain containing 3 [Homo sapiens]    62   2e-09
gi|134133265 FYVE, RhoGEF and PH domain containing 3 [Homo sapiens]    62   2e-09
gi|154240686 FYVE, RhoGEF and PH domain containing 6 [Homo sapiens]    61   5e-09

>gi|118150678 epithelial cell transforming sequence 2 oncogene-like
           [Homo sapiens]
          Length = 904

 Score = 1827 bits (4733), Expect = 0.0
 Identities = 904/904 (100%), Positives = 904/904 (100%)

Query: 1   MESFHTRFSAWTPFSNKSLNRQLFQERVALISHWFDLWTNKQRQEFLFAIFLRCTKSQLR 60
           MESFHTRFSAWTPFSNKSLNRQLFQERVALISHWFDLWTNKQRQEFLFAIFLRCTKSQLR
Sbjct: 1   MESFHTRFSAWTPFSNKSLNRQLFQERVALISHWFDLWTNKQRQEFLFAIFLRCTKSQLR 60

Query: 61  FVQDWFSERMQVAKVDFSTVLPRFISLYIFSFLSPKDLCAAAQVSWPWKFLTEQDCLWMP 120
           FVQDWFSERMQVAKVDFSTVLPRFISLYIFSFLSPKDLCAAAQVSWPWKFLTEQDCLWMP
Sbjct: 61  FVQDWFSERMQVAKVDFSTVLPRFISLYIFSFLSPKDLCAAAQVSWPWKFLTEQDCLWMP 120

Query: 121 KCVKFGWFLPYTPTDNEYGAWKRHYIACVSHLDWLTPREAAATYGTLNEPKTEDEELLER 180
           KCVKFGWFLPYTPTDNEYGAWKRHYIACVSHLDWLTPREAAATYGTLNEPKTEDEELLER
Sbjct: 121 KCVKFGWFLPYTPTDNEYGAWKRHYIACVSHLDWLTPREAAATYGTLNEPKTEDEELLER 180

Query: 181 QREKCLRKRIWEKIALRKKELFKVRPPWVSGTCCSSVLKPRCQPRLSQTVRERVGLHEAL 240
           QREKCLRKRIWEKIALRKKELFKVRPPWVSGTCCSSVLKPRCQPRLSQTVRERVGLHEAL
Sbjct: 181 QREKCLRKRIWEKIALRKKELFKVRPPWVSGTCCSSVLKPRCQPRLSQTVRERVGLHEAL 240

Query: 241 EKQLVLTSLETLPKRSNISGSHSYPLLSKKNWHGVHKNDDRSSYALRPHFMLISSRIPAY 300
           EKQLVLTSLETLPKRSNISGSHSYPLLSKKNWHGVHKNDDRSSYALRPHFMLISSRIPAY
Sbjct: 241 EKQLVLTSLETLPKRSNISGSHSYPLLSKKNWHGVHKNDDRSSYALRPHFMLISSRIPAY 300

Query: 301 EMVMESVKAGVVSVVYEHSVTLESLLYLIEKALDGQKAQSIGIFSDGDSREINLLQGYKI 360
           EMVMESVKAGVVSVVYEHSVTLESLLYLIEKALDGQKAQSIGIFSDGDSREINLLQGYKI
Sbjct: 301 EMVMESVKAGVVSVVYEHSVTLESLLYLIEKALDGQKAQSIGIFSDGDSREINLLQGYKI 360

Query: 361 GVKNLLRPEVRDFWEKLGSYVATEEEGGHVDFFVPLGASEAGIEVLSQLSQLTGTFFTAP 420
           GVKNLLRPEVRDFWEKLGSYVATEEEGGHVDFFVPLGASEAGIEVLSQLSQLTGTFFTAP
Sbjct: 361 GVKNLLRPEVRDFWEKLGSYVATEEEGGHVDFFVPLGASEAGIEVLSQLSQLTGTFFTAP 420

Query: 421 TGIATGSYQHILSDWLGSQWGKAPSSIYFCESKLQTWSSFTDFLEETLKTVRKQLYPFFK 480
           TGIATGSYQHILSDWLGSQWGKAPSSIYFCESKLQTWSSFTDFLEETLKTVRKQLYPFFK
Sbjct: 421 TGIATGSYQHILSDWLGSQWGKAPSSIYFCESKLQTWSSFTDFLEETLKTVRKQLYPFFK 480

Query: 481 ELQKSISGRMIGQFMFDTMGMTNILNNQDTAQALADGLMELSKEDSERNVVEDNSWDTKS 540
           ELQKSISGRMIGQFMFDTMGMTNILNNQDTAQALADGLMELSKEDSERNVVEDNSWDTKS
Sbjct: 481 ELQKSISGRMIGQFMFDTMGMTNILNNQDTAQALADGLMELSKEDSERNVVEDNSWDTKS 540

Query: 541 RLSKNDLNFEALINLERILQKDSAEKRARVVRELLQSERKYVQILEIVRDVYVAPLKAAL 600
           RLSKNDLNFEALINLERILQKDSAEKRARVVRELLQSERKYVQILEIVRDVYVAPLKAAL
Sbjct: 541 RLSKNDLNFEALINLERILQKDSAEKRARVVRELLQSERKYVQILEIVRDVYVAPLKAAL 600

Query: 601 SSNRAILSAANIQIIFCDILQILSLNRQFLDNLRDRLQEWGPAHCVGEIVTKFGSQLNTY 660
           SSNRAILSAANIQIIFCDILQILSLNRQFLDNLRDRLQEWGPAHCVGEIVTKFGSQLNTY
Sbjct: 601 SSNRAILSAANIQIIFCDILQILSLNRQFLDNLRDRLQEWGPAHCVGEIVTKFGSQLNTY 660

Query: 661 TNFFNNYPVILKTIEKCREMIPAFRTFLKRHDKTIVTKMLSLPELLLYPSRRFEEYLNLL 720
           TNFFNNYPVILKTIEKCREMIPAFRTFLKRHDKTIVTKMLSLPELLLYPSRRFEEYLNLL
Sbjct: 661 TNFFNNYPVILKTIEKCREMIPAFRTFLKRHDKTIVTKMLSLPELLLYPSRRFEEYLNLL 720

Query: 721 YAVRLHTPAEHVDRGDLTTAIDQIKKYKGYIDQMKQNITMKDHLSDIQRIIWGCPTLSEV 780
           YAVRLHTPAEHVDRGDLTTAIDQIKKYKGYIDQMKQNITMKDHLSDIQRIIWGCPTLSEV
Sbjct: 721 YAVRLHTPAEHVDRGDLTTAIDQIKKYKGYIDQMKQNITMKDHLSDIQRIIWGCPTLSEV 780

Query: 781 NRYLIRVQDVAQLHCCDEEISFSLRLYEHIHDLSLFLFNDALLVSSRGTSHTPFERTSKT 840
           NRYLIRVQDVAQLHCCDEEISFSLRLYEHIHDLSLFLFNDALLVSSRGTSHTPFERTSKT
Sbjct: 781 NRYLIRVQDVAQLHCCDEEISFSLRLYEHIHDLSLFLFNDALLVSSRGTSHTPFERTSKT 840

Query: 841 TYQFIASVALHRLLIENIPDSKYVKNAFILQGPKYKWICATEIEDDKFLWLSVLRNAIKS 900
           TYQFIASVALHRLLIENIPDSKYVKNAFILQGPKYKWICATEIEDDKFLWLSVLRNAIKS
Sbjct: 841 TYQFIASVALHRLLIENIPDSKYVKNAFILQGPKYKWICATEIEDDKFLWLSVLRNAIKS 900

Query: 901 SMEK 904
           SMEK
Sbjct: 901 SMEK 904


>gi|27312027 F-box only protein 16 [Homo sapiens]
          Length = 292

 Score =  162 bits (411), Expect = 1e-39
 Identities = 84/213 (39%), Positives = 115/213 (53%), Gaps = 16/213 (7%)

Query: 6   TRFSAWTPFSNKSLNRQLFQERVALISHWFDLWTNKQRQEFLFAIFLRCTKSQLRFVQDW 65
           T+ S WTP +++ LN ++F+ER AL+  WFD WT+ QR+  L  +  RC+ SQ +F    
Sbjct: 17  TKMSTWTPLNHQLLNDRVFEERRALLGKWFDKWTDSQRRRILTGLLERCSLSQQKFCCRK 76

Query: 66  FSERMQVAKVDFSTVLPRFISLYIFSFLSPKDLCAAAQVSWPWKFLTEQDCLWMPKCVKF 125
             E++    +DF+T LPR +SLYIFSFL P+ LC  AQV W WK L E D LWM KC++F
Sbjct: 77  LQEKIPAEALDFTTKLPRVLSLYIFSFLDPRSLCRCAQVCWHWKNLAELDQLWMLKCLRF 136

Query: 126 GWFLPYTPTDNEYGAWKRHYIACVSHLDWLTPRE--------AAATYGTLNEPKTEDEEL 177
            W++ ++PT  E G WK+HYI  V  L    P+         A     T N P+ +   L
Sbjct: 137 NWYINFSPTPFEQGIWKKHYIQMVKELHITKPKTPPKDGFVIADVQLVTSNSPEEKQSPL 196

Query: 178 LERQREKCLRKRIWEKIALRKKELFKVRPPWVS 210
              +    LRK        +     K  PPW S
Sbjct: 197 SAFRSSSSLRK--------KNNSGEKALPPWRS 221


>gi|21735572 epithelial cell transforming sequence 2 oncogene
           protein [Homo sapiens]
          Length = 883

 Score =  110 bits (276), Expect = 5e-24
 Identities = 81/280 (28%), Positives = 131/280 (46%), Gaps = 20/280 (7%)

Query: 567 RARVVRELLQSERKYVQILEIVRDVYVAPLKAALSSNRAILSAANIQIIFCDILQILSLN 626
           R +V +EL Q+E  YV IL  +  ++  PL+        IL+   I+ IF  I  I  ++
Sbjct: 422 RWQVAKELYQTESNYVNILATIIQLFQVPLEEEGQRGGPILAPEEIKTIFGSIPDIFDVH 481

Query: 627 RQFLDNLRDRLQEWGPAHCVGEIVTKFGSQL-NTYTNFFNNYPVILKTIEKCREMIPAFR 685
            +  D+L D +  W  +  +G+I  K+   L  TY  F N + +  +TI KC +  P F 
Sbjct: 482 TKIKDDLEDLIVNWDESKSIGDIFLKYSKDLVKTYPPFVNFFEMSKETIIKCEKQKPRFH 541

Query: 686 TFLKRHDKTIVTKMLSLPELLLYPSRRFEEYLNLLYAVRLHTPAEHVDRGDLTTAIDQIK 745
            FLK +         SL ELL+ P +R      LL  ++ HT  E+ D+  L  AI  +K
Sbjct: 542 AFLKINQAKPECGRQSLVELLIRPVQRLPSVALLLNDLKKHTADENPDKSTLEKAIGSLK 601

Query: 746 KYKGYIDQMKQNITMKDHLSDIQRIIWGCP-TLSEVNRYLIRVQDVAQL--HCCDEEISF 802
           +   +I++ K+    +  + D+   + GCP  L   +R L++  +   L  H CD     
Sbjct: 602 EVMTHINEDKRKTEAQKQIFDVVYEVDGCPANLLSSHRSLVQRVETISLGEHPCDRG--- 658

Query: 803 SLRLYEHIHDLSLFLFNDALLVSSR-----GTSHTPFERT 837
                     ++LFLFND L ++ +     GT  +P  +T
Sbjct: 659 --------EQVTLFLFNDCLEIARKRHKVIGTFRSPHGQT 690


>gi|224586880 Ras protein-specific guanine nucleotide-releasing
           factor 1 isoform 3 [Homo sapiens]
          Length = 1257

 Score = 95.9 bits (237), Expect = 2e-19
 Identities = 69/273 (25%), Positives = 135/273 (49%), Gaps = 7/273 (2%)

Query: 562 DSAEKRARVVRELLQSERKYVQILEIVRDVYVAPLKAALSSNRAILSAANIQIIFCDILQ 621
           DS  KR +VV  +L++E +YVQ L I+ + ++ PL+ A SS +  ++  ++  IF +   
Sbjct: 236 DSMRKRNQVVFSMLEAEAEYVQQLHILVNNFLRPLRMAASSKKPPITHDDVSSIFLNSET 295

Query: 622 ILSLNRQFLDNLRDRLQEWGPAHCVGEIVTKFGSQLNTYTNFFNNYPVILKTIEKCREMI 681
           I+ L++ F   L+ R+  W P   + ++       LN Y  F  N+   L+ +  C++  
Sbjct: 296 IMFLHQIFYQGLKARISSW-PTLVLADLFDILLPMLNIYQEFVRNHQYSLQILAHCKQN- 353

Query: 682 PAFRTFLKRHDKTIVTKMLSLPELLLYPSRRFEEYLNLLYAVRLHTPAEHVDRGDLTTAI 741
             F   LK ++     +  +L   L YP  +   Y+  L+ +  HTP EHV+R  L  A 
Sbjct: 354 RDFDKLLKHYEAKPDCEERTLETFLTYPMFQIPRYILTLHELLAHTPHEHVERNSLDYAK 413

Query: 742 DQIKKYKGYI-DQMKQNITMKDHLSDIQRIIWGCPTLSEVNRYLIRVQDVAQLHCCDEEI 800
            ++++    + D++ +   ++ +L+  + II GC  L + ++  +R   + Q+   ++  
Sbjct: 414 SKLEELSRIMHDEVSETENIRKNLAIERMIIEGCEILLDTSQTFVRQGSLIQVPMSEKGK 473

Query: 801 SFSLRL----YEHIHDLSLFLFNDALLVSSRGT 829
               RL     +   +   FLF+  L++ +RG+
Sbjct: 474 ITRGRLGSLSLKKEGERQCFLFSKHLIICTRGS 506


>gi|24797099 Ras protein-specific guanine nucleotide-releasing
           factor 1 isoform 1 [Homo sapiens]
          Length = 1273

 Score = 95.9 bits (237), Expect = 2e-19
 Identities = 69/273 (25%), Positives = 135/273 (49%), Gaps = 7/273 (2%)

Query: 562 DSAEKRARVVRELLQSERKYVQILEIVRDVYVAPLKAALSSNRAILSAANIQIIFCDILQ 621
           DS  KR +VV  +L++E +YVQ L I+ + ++ PL+ A SS +  ++  ++  IF +   
Sbjct: 236 DSMRKRNQVVFSMLEAEAEYVQQLHILVNNFLRPLRMAASSKKPPITHDDVSSIFLNSET 295

Query: 622 ILSLNRQFLDNLRDRLQEWGPAHCVGEIVTKFGSQLNTYTNFFNNYPVILKTIEKCREMI 681
           I+ L++ F   L+ R+  W P   + ++       LN Y  F  N+   L+ +  C++  
Sbjct: 296 IMFLHQIFYQGLKARISSW-PTLVLADLFDILLPMLNIYQEFVRNHQYSLQILAHCKQN- 353

Query: 682 PAFRTFLKRHDKTIVTKMLSLPELLLYPSRRFEEYLNLLYAVRLHTPAEHVDRGDLTTAI 741
             F   LK ++     +  +L   L YP  +   Y+  L+ +  HTP EHV+R  L  A 
Sbjct: 354 RDFDKLLKHYEAKPDCEERTLETFLTYPMFQIPRYILTLHELLAHTPHEHVERNSLDYAK 413

Query: 742 DQIKKYKGYI-DQMKQNITMKDHLSDIQRIIWGCPTLSEVNRYLIRVQDVAQLHCCDEEI 800
            ++++    + D++ +   ++ +L+  + II GC  L + ++  +R   + Q+   ++  
Sbjct: 414 SKLEELSRIMHDEVSETENIRKNLAIERMIIEGCEILLDTSQTFVRQGSLIQVPMSEKGK 473

Query: 801 SFSLRL----YEHIHDLSLFLFNDALLVSSRGT 829
               RL     +   +   FLF+  L++ +RG+
Sbjct: 474 ITRGRLGSLSLKKEGERQCFLFSKHLIICTRGS 506


>gi|38505170 Ras protein-specific guanine nucleotide-releasing
           factor 2 [Homo sapiens]
          Length = 1237

 Score = 87.8 bits (216), Expect = 4e-17
 Identities = 65/273 (23%), Positives = 129/273 (47%), Gaps = 7/273 (2%)

Query: 562 DSAEKRARVVRELLQSERKYVQILEIVRDVYVAPLKAALSSNRAILSAANIQIIFCDILQ 621
           +S  KR ++V  ++++E +YV  L I+ + ++ PL+ A SS +  +S  ++  IF +   
Sbjct: 239 ESMRKRNQIVFTMVEAESEYVHQLYILVNGFLRPLRMAASSKKPPISHDDVSSIFLNSET 298

Query: 622 ILSLNRQFLDNLRDRLQEWGPAHCVGEIVTKFGSQLNTYTNFFNNYPVILKTIEKCREMI 681
           I+ L+  F   L+ R+  W P   + ++       LN Y  F  N+   L+ +  C++  
Sbjct: 299 IMFLHEIFHQGLKARIANW-PTLILADLFDILLPMLNIYQEFVRNHQYSLQVLANCKQN- 356

Query: 682 PAFRTFLKRHDKTIVTKMLSLPELLLYPSRRFEEYLNLLYAVRLHTPAEHVDRGDLTTAI 741
             F   LK+++     +   L   L YP  +   Y+  L+ +  HTP EHV+R  L  A 
Sbjct: 357 RDFDKLLKQYEANPACEGRMLETFLTYPMFQIPRYIITLHELLAHTPHEHVERKSLEFAK 416

Query: 742 DQIKKYKGYI-DQMKQNITMKDHLSDIQRIIWGCPTLSEVNRYLIRVQDVAQLHCCDEEI 800
            ++++    + D++     ++ +L+  + I+ GC  L + ++  IR   + Q+   +   
Sbjct: 417 SKLEELSRVMHDEVSDTENIRKNLAIERMIVEGCDILLDTSQTFIRQGSLIQVPSVERGK 476

Query: 801 SFSLRL----YEHIHDLSLFLFNDALLVSSRGT 829
              +RL     +   +   FLF    L+ +R +
Sbjct: 477 LSKVRLGSLSLKKEGERQCFLFTKHFLICTRSS 509


>gi|82546845 breakpoint cluster region isoform 2 [Homo sapiens]
          Length = 1227

 Score = 85.5 bits (210), Expect = 2e-16
 Identities = 62/208 (29%), Positives = 104/208 (50%), Gaps = 13/208 (6%)

Query: 565 EKRARVVRELLQSERKYVQILEIVRDVYVAPLKAALSSNRAILSAANIQIIFCDILQILS 624
           E R  V+  +L SE  Y+  LE +  + + PLKAA ++++ +L++  I+ IF  + ++  
Sbjct: 497 EMRKWVLSGILASEETYLSHLEALL-LPMKPLKAAATTSQPVLTSQQIETIFFKVPELYE 555

Query: 625 LNRQFLDNLRDRLQEWGPAHCVGEIVTKFGSQLNTYTNFFNNYPVILKTIEKC------- 677
           ++++F D L  R+Q+W     VG++  K  SQL  Y  F +NY V ++  EKC       
Sbjct: 556 IHKEFYDGLFPRVQQWSHQQRVGDLFQKLASQLGVYRAFVDNYGVAMEMAEKCCQANAQF 615

Query: 678 REMIPAFRTFLKRHDKTIVTKMLSLPELLLYPSRRFEEYLNLLYAVRLHTPAEHVDRGDL 737
            E+    R    +  K   TK  SL  LL  P  R      +L+ +  HTPA H D   L
Sbjct: 616 AEISENLRARSNKDAKDPTTKN-SLETLLYKPVDRVTRSTLVLHDLLKHTPASHPDHPLL 674

Query: 738 TTAIDQIKKYKGYIDQ----MKQNITMK 761
             A+   + +   I++     +Q++T+K
Sbjct: 675 QDALRISQNFLSSINEEITPRRQSMTVK 702


>gi|82546843 breakpoint cluster region isoform 1 [Homo sapiens]
          Length = 1271

 Score = 85.5 bits (210), Expect = 2e-16
 Identities = 62/208 (29%), Positives = 104/208 (50%), Gaps = 13/208 (6%)

Query: 565 EKRARVVRELLQSERKYVQILEIVRDVYVAPLKAALSSNRAILSAANIQIIFCDILQILS 624
           E R  V+  +L SE  Y+  LE +  + + PLKAA ++++ +L++  I+ IF  + ++  
Sbjct: 497 EMRKWVLSGILASEETYLSHLEALL-LPMKPLKAAATTSQPVLTSQQIETIFFKVPELYE 555

Query: 625 LNRQFLDNLRDRLQEWGPAHCVGEIVTKFGSQLNTYTNFFNNYPVILKTIEKC------- 677
           ++++F D L  R+Q+W     VG++  K  SQL  Y  F +NY V ++  EKC       
Sbjct: 556 IHKEFYDGLFPRVQQWSHQQRVGDLFQKLASQLGVYRAFVDNYGVAMEMAEKCCQANAQF 615

Query: 678 REMIPAFRTFLKRHDKTIVTKMLSLPELLLYPSRRFEEYLNLLYAVRLHTPAEHVDRGDL 737
            E+    R    +  K   TK  SL  LL  P  R      +L+ +  HTPA H D   L
Sbjct: 616 AEISENLRARSNKDAKDPTTKN-SLETLLYKPVDRVTRSTLVLHDLLKHTPASHPDHPLL 674

Query: 738 TTAIDQIKKYKGYIDQ----MKQNITMK 761
             A+   + +   I++     +Q++T+K
Sbjct: 675 QDALRISQNFLSSINEEITPRRQSMTVK 702


>gi|58761492 Rho guanine nucleotide exchange factor (GEF) 10-like
           isoform 1 [Homo sapiens]
          Length = 1279

 Score = 84.3 bits (207), Expect = 5e-16
 Identities = 69/266 (25%), Positives = 127/266 (47%), Gaps = 15/266 (5%)

Query: 567 RARVVRELLQSERKYVQILEIVRDVYVAPLKAALSSNRAILSAANIQIIFCDILQILSLN 626
           R  ++  ++QSE  YV+ L+ +   Y  PL   +      LSA   Q++F  + +IL  +
Sbjct: 317 RRHILGSIVQSEGSYVESLKRILQDYRNPL---MEMEPKALSARKCQVVFFRVKEILHCH 373

Query: 627 RQFLDNLRDRLQEWGPAHCVGEI-VTKFGSQ--LNTYTNFFNNYPVILKTIEKCREMIPA 683
             F   L  R+ EW     +G++ V  F     L+ Y+++ NN+   +  I+K     PA
Sbjct: 374 SMFQIALSSRVAEWDSTEKIGDLFVASFSKSMVLDVYSDYVNNFTSAMSIIKKACLTKPA 433

Query: 684 FRTFLKRHDKTIVTKMLSLPELLLYPSRRFEEYLNLLYAVRLHTPAEHVDRGDLTTAIDQ 743
           F  FLKR  +      ++L  L++ P +RF +++ LL  +  +TP  H DR  L  A+ +
Sbjct: 434 FLEFLKRR-QVCSPDRVTLYGLMVKPIQRFPQFILLLQDMLKNTPRGHPDRLSLQLALTE 492

Query: 744 IKKYKGYIDQMKQNITMKDHLSDIQRIIWGCPTLSEVNRYLIRVQDVAQLHCCD---EEI 800
           ++     +++ K+   + D +++IQ++       S +N+ L   Q   QL  C+   E +
Sbjct: 493 LETLAEKLNEQKR---LADQVAEIQQLTKSVSDRSSLNKLLTSGQ--RQLLLCETLTETV 547

Query: 801 SFSLRLYEHIHDLSLFLFNDALLVSS 826
                      +  +FL ND L+ ++
Sbjct: 548 YGDRGQLIKSKERRVFLLNDMLVCAN 573


>gi|74136547 Rho guanine nucleotide exchange factor (GEF) 10-like
           isoform 2 [Homo sapiens]
          Length = 1240

 Score = 84.3 bits (207), Expect = 5e-16
 Identities = 69/266 (25%), Positives = 127/266 (47%), Gaps = 15/266 (5%)

Query: 567 RARVVRELLQSERKYVQILEIVRDVYVAPLKAALSSNRAILSAANIQIIFCDILQILSLN 626
           R  ++  ++QSE  YV+ L+ +   Y  PL   +      LSA   Q++F  + +IL  +
Sbjct: 278 RRHILGSIVQSEGSYVESLKRILQDYRNPL---MEMEPKALSARKCQVVFFRVKEILHCH 334

Query: 627 RQFLDNLRDRLQEWGPAHCVGEI-VTKFGSQ--LNTYTNFFNNYPVILKTIEKCREMIPA 683
             F   L  R+ EW     +G++ V  F     L+ Y+++ NN+   +  I+K     PA
Sbjct: 335 SMFQIALSSRVAEWDSTEKIGDLFVASFSKSMVLDVYSDYVNNFTSAMSIIKKACLTKPA 394

Query: 684 FRTFLKRHDKTIVTKMLSLPELLLYPSRRFEEYLNLLYAVRLHTPAEHVDRGDLTTAIDQ 743
           F  FLKR  +      ++L  L++ P +RF +++ LL  +  +TP  H DR  L  A+ +
Sbjct: 395 FLEFLKRR-QVCSPDRVTLYGLMVKPIQRFPQFILLLQDMLKNTPRGHPDRLSLQLALTE 453

Query: 744 IKKYKGYIDQMKQNITMKDHLSDIQRIIWGCPTLSEVNRYLIRVQDVAQLHCCD---EEI 800
           ++     +++ K+   + D +++IQ++       S +N+ L   Q   QL  C+   E +
Sbjct: 454 LETLAEKLNEQKR---LADQVAEIQQLTKSVSDRSSLNKLLTSGQ--RQLLLCETLTETV 508

Query: 801 SFSLRLYEHIHDLSLFLFNDALLVSS 826
                      +  +FL ND L+ ++
Sbjct: 509 YGDRGQLIKSKERRVFLLNDMLVCAN 534


>gi|229094128 active breakpoint cluster region-related  protein
           isoform c [Homo sapiens]
          Length = 813

 Score = 80.9 bits (198), Expect = 5e-15
 Identities = 52/175 (29%), Positives = 85/175 (48%), Gaps = 7/175 (4%)

Query: 565 EKRARVVRELLQSERKYVQILEIVRDVYVAPLKAALSSNRAILSAANIQIIFCDILQILS 624
           E R  V+   L SE  Y+  LE +  + + PLKA  ++++ +L+   I+ IF  I  I  
Sbjct: 44  EMRKLVLSGFLASEEIYINQLEALL-LPMKPLKATATTSQPVLTIQQIETIFYKIQDIYE 102

Query: 625 LNRQFLDNLRDRLQEWGPAHCVGEIVTKFGSQLNTYTNFFNNYPVILKTIEKCREMIPAF 684
           ++++F DNL  ++Q+W     +G +  K  SQL  Y  F +NY V L+T EKC +    F
Sbjct: 103 IHKEFYDNLCPKVQQWDSQVTMGHLFQKLASQLGVYKAFVDNYKVALETAEKCSQSNNQF 162

Query: 685 RTFLKR------HDKTIVTKMLSLPELLLYPSRRFEEYLNLLYAVRLHTPAEHVD 733
           +   +        D       +++  LL  P  R      +L+ +  HTP +H D
Sbjct: 163 QKISEELKVKGPKDSKDSHTSVTMEALLYKPIDRVTRSTLVLHDLLKHTPVDHPD 217


>gi|38679957 active breakpoint cluster region-related  protein
           isoform a [Homo sapiens]
          Length = 859

 Score = 80.9 bits (198), Expect = 5e-15
 Identities = 52/175 (29%), Positives = 85/175 (48%), Gaps = 7/175 (4%)

Query: 565 EKRARVVRELLQSERKYVQILEIVRDVYVAPLKAALSSNRAILSAANIQIIFCDILQILS 624
           E R  V+   L SE  Y+  LE +  + + PLKA  ++++ +L+   I+ IF  I  I  
Sbjct: 90  EMRKLVLSGFLASEEIYINQLEALL-LPMKPLKATATTSQPVLTIQQIETIFYKIQDIYE 148

Query: 625 LNRQFLDNLRDRLQEWGPAHCVGEIVTKFGSQLNTYTNFFNNYPVILKTIEKCREMIPAF 684
           ++++F DNL  ++Q+W     +G +  K  SQL  Y  F +NY V L+T EKC +    F
Sbjct: 149 IHKEFYDNLCPKVQQWDSQVTMGHLFQKLASQLGVYKAFVDNYKVALETAEKCSQSNNQF 208

Query: 685 RTFLKR------HDKTIVTKMLSLPELLLYPSRRFEEYLNLLYAVRLHTPAEHVD 733
           +   +        D       +++  LL  P  R      +L+ +  HTP +H D
Sbjct: 209 QKISEELKVKGPKDSKDSHTSVTMEALLYKPIDRVTRSTLVLHDLLKHTPVDHPD 263


>gi|38679954 active breakpoint cluster region-related  protein
           isoform b [Homo sapiens]
          Length = 822

 Score = 80.9 bits (198), Expect = 5e-15
 Identities = 52/175 (29%), Positives = 85/175 (48%), Gaps = 7/175 (4%)

Query: 565 EKRARVVRELLQSERKYVQILEIVRDVYVAPLKAALSSNRAILSAANIQIIFCDILQILS 624
           E R  V+   L SE  Y+  LE +  + + PLKA  ++++ +L+   I+ IF  I  I  
Sbjct: 53  EMRKLVLSGFLASEEIYINQLEALL-LPMKPLKATATTSQPVLTIQQIETIFYKIQDIYE 111

Query: 625 LNRQFLDNLRDRLQEWGPAHCVGEIVTKFGSQLNTYTNFFNNYPVILKTIEKCREMIPAF 684
           ++++F DNL  ++Q+W     +G +  K  SQL  Y  F +NY V L+T EKC +    F
Sbjct: 112 IHKEFYDNLCPKVQQWDSQVTMGHLFQKLASQLGVYKAFVDNYKVALETAEKCSQSNNQF 171

Query: 685 RTFLKR------HDKTIVTKMLSLPELLLYPSRRFEEYLNLLYAVRLHTPAEHVD 733
           +   +        D       +++  LL  P  R      +L+ +  HTP +H D
Sbjct: 172 QKISEELKVKGPKDSKDSHTSVTMEALLYKPIDRVTRSTLVLHDLLKHTPVDHPD 226


>gi|21361458 Rho guanine nucleotide exchange factor (GEF) 17 [Homo
            sapiens]
          Length = 2063

 Score = 80.9 bits (198), Expect = 5e-15
 Identities = 71/289 (24%), Positives = 127/289 (43%), Gaps = 21/289 (7%)

Query: 561  KDSAEKRARVVRELLQSERKYVQILEIVRDVYVAPLKAALSSNRAILSAANIQIIFCDIL 620
            K   + R  V   LL +E+ YV+ L  +   Y+ PLK     N  +   + +  IF  I 
Sbjct: 1061 KPQVDMRKHVAMTLLDTEQSYVESLRTLMQGYMQPLKQ--PENSVLCDPSLVDEIFDQIP 1118

Query: 621  QILSLNRQFLDNLRDRLQEWGPAHCVGEIVTKFGSQ---LNTYTNFFNNYPVILKTIEKC 677
            ++L  + QFL+ +R  +Q W     VG ++ +  S+   +N Y+ + +N+      +   
Sbjct: 1119 ELLEHHEQFLEQVRHCMQTWHAQQKVGALLVQSFSKDVLVNIYSAYIDNFLNAKDAVRVA 1178

Query: 678  REMIPAFRTFLKRHDKTIVTKMLSLPELLLYPSRRFEEYLNLLYAVRLHTPAEHVDRGDL 737
            +E  PAF  FL++  +    K  +L +L++ P +R   Y  L+  +  HTP +H D   L
Sbjct: 1179 KEARPAFLKFLEQSMRENKEKQ-ALSDLMIKPVQRIPRYELLVKDLLKHTPEDHPDHPLL 1237

Query: 738  TTAIDQIKKYKGYIDQMKQNITMKDH----LSDIQRIIWGCPTLSEVNRYLIRVQDVAQL 793
              A   IK+    I++  ++    +     L +I+  I G   L    R  +R       
Sbjct: 1238 LEAQRNIKQVAERINKGVRSAEEAERHARVLQEIEAHIEGMEDLQAPLRRFLR------- 1290

Query: 794  HCCDEEISFSLRLYEHIHDLSLFLFNDALLVSSRGTSHTPFERTSKTTY 842
                +E+   ++      D SLFLF D ++ ++         R+S + Y
Sbjct: 1291 ----QEMVIEVKAIGGKKDRSLFLFTDLIVCTTLKRKSGSLRRSSMSLY 1335


>gi|62548864 Rho guanine nucleotide exchange factor 10 [Homo
           sapiens]
          Length = 1344

 Score = 80.5 bits (197), Expect = 7e-15
 Identities = 66/270 (24%), Positives = 125/270 (46%), Gaps = 19/270 (7%)

Query: 567 RARVVRELLQSERKYVQILEIVRDVYVAPLKAALSSNRAILSAANIQIIFCDILQILSLN 626
           R  ++  ++ SE+ YV  L+ + + Y  PL         +LS   ++ +F  + +IL  +
Sbjct: 397 RRYILGSVVDSEKNYVDALKRILEQYEKPLS---EMEPKVLSERKLKTVFYRVKEILQCH 453

Query: 627 RQFLDNLRDRLQEWGPAHCVGEI-VTKFGSQ--LNTYTNFFNNYPVILKTIEKCREMIPA 683
             F   L  R+ EW     +G++ V  F     L+ Y+ + NN+   +  ++K     PA
Sbjct: 454 SLFQIALASRVSEWDSVEMIGDVFVASFSKSMVLDAYSEYVNNFSTAVAVLKKTCATKPA 513

Query: 684 FRTFLKRHDKTIVTKMLSLPELLLYPSRRFEEYLNLLYAVRLHTPAEHVDRGDLTTAIDQ 743
           F  FLK+  +    +  +L  L++ P +RF +++ LL  +  +T   H DR  L  A+ +
Sbjct: 514 FLEFLKQEQEASPDRT-TLYSLMMKPIQRFPQFILLLQDMLKNTSKGHPDRLPLQMALTE 572

Query: 744 IKKYKGYIDQMKQNITMKDHLSDIQRII---WGCPTLSEVNRYLIRVQDVAQLHCCDEEI 800
           ++     +++ K++   +  +  I + I   +    LS  +RYLIR  D+ +    D   
Sbjct: 573 LETLAEKLNERKRDADQRCEVKQIAKAINERYLNKLLSSGSRYLIRSDDMIETVYNDRGE 632

Query: 801 SFSLRLYEHIHDLSLFLFNDALL---VSSR 827
               +      +  +F+ ND L+   VSSR
Sbjct: 633 IVKTK------ERRVFMLNDVLMCATVSSR 656


>gi|34452732 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac
           exchange factor 1 [Homo sapiens]
          Length = 1659

 Score = 78.2 bits (191), Expect = 3e-14
 Identities = 83/367 (22%), Positives = 162/367 (44%), Gaps = 42/367 (11%)

Query: 567 RARVVRELLQSERKYVQILEIVRDVYVAPLKAALSSN-RAILSAANIQIIFCDILQILSL 625
           R  V+ E+L +ER YV  L  ++  ++  ++  ++ +    L+  N++++F +I  IL +
Sbjct: 50  RLCVLNEILGTERDYVGTLRFLQSAFLHRIRQNVADSVEKGLTEENVKVLFSNIEDILEV 109

Query: 626 NRQFLDNLRDRLQ-EWGPAHCVGEIVTKFGSQLNTYTNFFNNYPVILKTIEKCREMIPAF 684
           ++ FL  L   L  E    H +G +  KF  +   Y  + +N+   L+ + +  + IP  
Sbjct: 110 HKDFLAALEYCLHPEPQSQHELGNVFLKFKDKFCVYEEYCSNHEKALRLLVELNK-IPTV 168

Query: 685 RTFLKRHDKTIVTKMLSLP--ELLLYPSRRFEEYLNLLYAVRLHTPAEHVDRGDLTTAID 742
           R FL         K   +P    LL P +R  +Y  LL  +   TP +H D   + +A+ 
Sbjct: 169 RAFLLSCMLLGGRKTTDIPLEGYLLSPIQRICKYPLLLKELAKRTPGKHPDHPAVQSALQ 228

Query: 743 QIKKYKGYIDQMKQNITMKDHLSDIQRII--WGCPTLSEVNRYLIRVQDVAQLHCCDEEI 800
            +K     I++ K+ +   + L  +Q  I  W    L+++   L+    + ++       
Sbjct: 229 AMKTVCSNINETKRQMEKLEALEQLQSHIEGWEGSNLTDICTQLLLQGTLLKISA----- 283

Query: 801 SFSLRLYEHIHDLSLFLFNDALLVSSRGTSHTPFERTSKTTYQFIASVALHR-------L 853
                   +I + + FLF++ L+   R +  T  ++++K T     S+ + R       +
Sbjct: 284 -------GNIQERAFFLFDNLLVYCKRKSRVTGSKKSTKRTKSINGSLYIFRGRINTEVM 336

Query: 854 LIENIPD--SKYVKNAF-------ILQGPKYKW-ICATEIEDDKFLWLSVL------RNA 897
            +EN+ D  + Y  N +       I    K KW +C  +  ++K  WL  +      R +
Sbjct: 337 EVENVEDGTADYHSNGYTVTNGWKIHNTAKNKWFVCMAKTAEEKQKWLDAIIREREQRES 396

Query: 898 IKSSMEK 904
           +K  ME+
Sbjct: 397 LKLGMER 403


>gi|198041928 FYVE, RhoGEF and PH domain containing 4 [Homo sapiens]
          Length = 766

 Score = 77.0 bits (188), Expect = 7e-14
 Identities = 78/374 (20%), Positives = 158/374 (42%), Gaps = 26/374 (6%)

Query: 531 VEDNSWDTKSRLSKNDLNFEALINLERI-----LQKDSAEKRARVVRELLQSERKYVQIL 585
           +E+   +T++++ + + N E+ + LE++     +++ + +K  ++  ELL +ER YV  L
Sbjct: 167 LEERGAETETKVQERE-NGESPLELEQLDQHHEMKETNEQKLHKIANELLLTERAYVNRL 225

Query: 586 EIVRDVYVAPLKAALSSNRAILSAANIQIIFCDILQILSLNRQFL-DNLRDRLQEWGPAH 644
           +++  V+   L     +NR    A  +  IF +I  I + + +FL   L  R+QEW    
Sbjct: 226 DLLDQVFYCKLLE--EANRGSFPAEMVNKIFSNISSINAFHSKFLLPELEKRMQEWETTP 283

Query: 645 CVGEIVTKFGSQLNTYTNFFNNYPVILKTIEKCREMIPAFRTFLKRHDKTIVTKMLSLPE 704
            +G+I+ K    L  Y  +   +   ++ ++   E IP F++ ++   K  +   L+L  
Sbjct: 284 RIGDILQKLAPFLKMYGEYVKGFDNAMELVKNMTERIPQFKSVVEEIQKQKICGSLTLQH 343

Query: 705 LLLYPSRRFEEYLNLLYAVRLHTPAEHVDRGDLTTAIDQIKKYKGYIDQMKQNITMKDHL 764
            +L P +R   Y  LL       P + +D  D   +++ I     + +   + +     L
Sbjct: 344 HMLEPVQRIPRYEMLLKDYLRKLPPDSLDWNDAKKSLEIISTAASHSNSAIRKMENLKKL 403

Query: 765 SDIQRIIWGCPTLSEVNRYLIRVQDVAQLHCCDEEISFSLRLYEHIHDLSLFLFNDALLV 824
            +I  ++     +   +  LI+   + +L   +              +  LFLFN+ LL 
Sbjct: 404 LEIYEMLGEEEDIVNPSNELIKEGQILKLAARNTS----------AQERYLFLFNNMLLY 453

Query: 825 SSRGTSHTPFERTSKTTYQFIASVALHRLLIENIPDSKYVKNAFILQGPKYKWICATEIE 884
                S    + T +T       V +  + I    + +Y  + F + G +          
Sbjct: 454 CVPKFSLVGSKFTVRT------RVGIDGMKIVETQNEEY-PHTFQVSGKERTLELQASSA 506

Query: 885 DDKFLWLSVLRNAI 898
            DK  W+  L+  I
Sbjct: 507 QDKEEWIKALQETI 520


>gi|7662310 FERM, RhoGEF and pleckstrin domain protein 2 [Homo
           sapiens]
          Length = 1054

 Score = 74.7 bits (182), Expect = 4e-13
 Identities = 78/347 (22%), Positives = 148/347 (42%), Gaps = 34/347 (9%)

Query: 564 AEKRARVVRELLQSERKYVQILEIVRDVYVAPLKAALSSNRAILSAANIQIIFCDILQIL 623
           A++   +V+E+L +ER Y++ LE++   +    ++A+    A + A  + ++F +I  I 
Sbjct: 533 ADEAYFIVKEILATERTYLKDLEVITVWF----RSAVVKEDA-MPATLMTLLFSNIDPIY 587

Query: 624 SLNRQFLDNLRDRLQEW-GPAHC--------VGEIVTKFGSQLNTYTNFFNNYPVILKTI 674
             +R FL  +  RL  W GP+          +G+I+ +   QL  +T++F  +  +L  +
Sbjct: 588 EFHRGFLREVEQRLALWEGPSKAHTKGSHQRIGDILLRNMRQLKEFTSYFQRHDEVLTEL 647

Query: 675 EKCREMIPAFRTFLKRHDKTIVTKMLSLPELLLYPSRRFEEYLNLLYAVRLHTPAEHVDR 734
           EK  +         K  +   V   L L   LL P +R   Y  LL  +  H    H D 
Sbjct: 648 EKATKRCKKLEAVYKEFELQKVC-YLPLNTFLLKPIQRLLHYRLLLRRLCGHYSPGHHDY 706

Query: 735 GDLTTAIDQIKKYKGYIDQMKQNITMKDHLSDIQRIIWGCPTLSEVNRYLIRVQDVAQLH 794
            D   A+  I +    +  +   +     L+++QR + G   L    R  IR   + +L 
Sbjct: 707 ADCHDALKAITEVTTTLQHILIRLENLQKLTELQRDLVGIENLIAPGREFIREGCLHKL- 765

Query: 795 CCDEEISFSLRLYEHIHDLSLFLFNDALLVSSRGTSHTPFERTSKTTYQFIASVALHRLL 854
                        + +     FLF+D LL +S+G + T       + ++    + L  +L
Sbjct: 766 -----------TKKGLQQRMFFLFSDMLLYTSKGVAGT-------SHFRIRGLLPLQGML 807

Query: 855 IENIPDSKYVKNAFILQGPKYKWICATEIEDDKFLWLSVLRNAIKSS 901
           +E   +   V + F +   +   + A     +K  W+  L +AI+++
Sbjct: 808 VEESDNEWSVPHCFTIYAAQKTIVVAASTRLEKEKWMLDLNSAIQAA 854


>gi|71274148 pleckstrin homology domain containing, family G (with
           RhoGef domain) member 1 [Homo sapiens]
          Length = 1385

 Score = 74.3 bits (181), Expect = 5e-13
 Identities = 75/333 (22%), Positives = 140/333 (42%), Gaps = 36/333 (10%)

Query: 569 RVVRELLQSERKYVQILEIVRDVYVAPLKAALSSNRAILSAANIQIIFCDILQILSLNRQ 628
           RVV+E+L++ER YVQ L+ + + Y+  ++      +  L       +F +I  I   N +
Sbjct: 116 RVVQEILETERTYVQDLKSIVEDYLDCIR---DQTKLPLGTEERSALFGNIQDIYHFNSE 172

Query: 629 FLDNLRDRLQEWGPAHCVGEIVTKFGSQLNTYTNFFNNYPVILKTIEKCREMIPAFRTFL 688
            L +L +   E  P   + E       + + YT +  NYP  +  + +C       + F 
Sbjct: 173 LLQDLENC--ENDPV-AIAECFVSKSEEFHIYTQYCTNYPRSVAVLTECMRNKILAKFFR 229

Query: 689 KRHDKTIVTKMLSLPELLLYPSRRFEEYLNLLYAVRLHTPAEHVDRGDLTTAIDQIKKYK 748
           +R +   +   L L   LL P +R  +Y  LL+ +  H   +      +  AID +++  
Sbjct: 230 ERQET--LKHSLPLGSYLLKPVQRILKYHLLLHEIENHLDKDTEGYDVVLDAIDTMQRVA 287

Query: 749 GYIDQMKQNITMKDHLSDIQRII--WGCPTLSEVNRYLIRVQDVAQLHCCDEEISFSLRL 806
            +I+ MK+       L +IQ ++  W  P L+     +               +  + R+
Sbjct: 288 WHINDMKRKHEHAVRLQEIQSLLTNWKGPDLTSYGELV---------------LEGTFRI 332

Query: 807 YEHIHDLSLFLFNDALLVSSRGTSHTPFERTSKTTYQFIASVALHRL-LIENIPDSKYVK 865
               ++ +LFLF+  LL++ +             T+ + A +    L L+E IP      
Sbjct: 333 QRAKNERTLFLFDKLLLITKK----------RDDTFTYKAHILCGNLMLVEVIPKEPLSF 382

Query: 866 NAFILQGPKYKWICATEIEDDKFLWLSVLRNAI 898
           + F  + PK +     + + DK LW+  L+  I
Sbjct: 383 SVFHYKNPKLQHTVQAKSQQDKRLWVLHLKRLI 415


>gi|189217917 FYVE, RhoGEF and PH domain containing 2 [Homo sapiens]
          Length = 655

 Score = 72.0 bits (175), Expect = 2e-12
 Identities = 48/181 (26%), Positives = 85/181 (46%), Gaps = 2/181 (1%)

Query: 565 EKRARVVRELLQSERKYVQILEIVRDVYVAPLKAALSSNRAILSAANIQIIFCDILQILS 624
           E   ++V+ELL++E+ YV  L ++  V+   L     S++A      +++IF +I  I  
Sbjct: 101 EPEKKIVQELLETEQAYVARLHLLDQVFFQELLKTARSSKAFPEDV-VRVIFSNISSIYQ 159

Query: 625 LNRQF-LDNLRDRLQEWGPAHCVGEIVTKFGSQLNTYTNFFNNYPVILKTIEKCREMIPA 683
            + QF L  L+ RL +W     +G+++ K    L  Y+ +  N+    + +    +  P 
Sbjct: 160 FHSQFFLPELQRRLDDWTANPRIGDVIQKLAPFLKMYSEYVKNFERAAELLATWTDKSPL 219

Query: 684 FRTFLKRHDKTIVTKMLSLPELLLYPSRRFEEYLNLLYAVRLHTPAEHVDRGDLTTAIDQ 743
           F+  L R   +  +  L+L   +L P +R   Y  LL       PA+  D+ D   A+D 
Sbjct: 220 FQEVLTRIQSSEASGSLTLQHHMLEPVQRIPRYELLLKEYIQKLPAQAPDQADAQKALDM 279

Query: 744 I 744
           I
Sbjct: 280 I 280


>gi|24797153 faciogenital dysplasia protein [Homo sapiens]
          Length = 961

 Score = 65.9 bits (159), Expect = 2e-10
 Identities = 61/260 (23%), Positives = 105/260 (40%), Gaps = 12/260 (4%)

Query: 565 EKRARVVRELLQSERKYVQILEIVRDVYVAPLKAALSSNRAILSAANIQIIFCDILQILS 624
           +K   +  ELLQ+E+ YV  L ++  V+ A L    + NR+   A  +  IF +I  I  
Sbjct: 372 QKVFHIANELLQTEKAYVSRLHLLDQVFCARLLEE-ARNRSSFPADVVHGIFSNICSIYC 430

Query: 625 LNRQFL-DNLRDRLQEWGPAHCVGEIVTKFGSQLNTYTNFFNNYPVILKTIEKCREMIPA 683
            ++QFL   L  R++EW     +G+I+ K    L  Y  +  N+   ++ +    E    
Sbjct: 431 FHQQFLLPELEKRMEEWDRYPRIGDILQKLAPFLKMYGEYVKNFDRAVELVNTWTERSTQ 490

Query: 684 FRTFLKRHDKTIVTKMLSLPELLLYPSRRFEEYLNLLYAVRLHTPAEHVDRGDLTTAIDQ 743
           F+  +    K      L+L   +L P +R   Y  LL    L  P    D  D   +++ 
Sbjct: 491 FKVIIHEVQKEEACGNLTLQHHMLEPVQRIPRYELLLKDYLLKLPHGSPDSKDAQKSLEL 550

Query: 744 IKKYKGYIDQMKQNITMKDHLSDIQRIIWGCPTLSEVNRYLIRVQDVAQLHCCDEEISFS 803
           I     + +   + +     L  +  ++ G   +    + LI+   + +L   +      
Sbjct: 551 IATAAEHSNAAIRKMERMHKLLKVYELLGGEEDIVSPTKELIKEGHILKLSAKNGT---- 606

Query: 804 LRLYEHIHDLSLFLFNDALL 823
                   D  L LFND LL
Sbjct: 607 ------TQDRYLILFNDRLL 620


>gi|114145479 neuroepithelial cell transforming gene 1 isoform 1
           [Homo sapiens]
          Length = 596

 Score = 65.5 bits (158), Expect = 2e-10
 Identities = 72/296 (24%), Positives = 128/296 (43%), Gaps = 27/296 (9%)

Query: 566 KRARVVRELLQSERKYVQILEIVRDVYVAPLKAALSSNRAILSAANIQIIFCDILQILSL 625
           +R   + E+ + E+  ++ L++ R  Y  P+        +I+S   +  IF D+   + L
Sbjct: 174 RRQEAIYEMSRGEQDLIEDLKLARKAYHDPMLKL-----SIMSEEELTHIFGDLDSYIPL 228

Query: 626 NRQFLDNLRDRLQEWGPAHCVGEIVTKFGSQLNTYTNFFNNYPVILKTIEKCREMIPAFR 685
           +   L  + +  +  G    +G I+  +  +LN Y  + +N  +  K +   ++  P  +
Sbjct: 229 HEDLLTRIGEATKPDGTVEQIGHILVSWLPRLNAYRGYCSNQ-LAAKALLDQKKQDPRVQ 287

Query: 686 TFLKRHDKTIVTKMLSLPELLLYPSRRFEEYLNLLYAVRLHTPAEHVDRGDLTTAIDQIK 745
            FL+R  ++  ++ L L   L  P  R  +Y  LL  +  HTP EH D   L  AI    
Sbjct: 288 DFLQRCLESPFSRKLDLWSFLDIPRSRLVKYPLLLKEILKHTPKEHPDVQLLEDAI---- 343

Query: 746 KYKGYIDQMKQNITMKDHLSDIQRIIWGCPTLSEVNRYLIRVQDVAQLHCCDEEISFSLR 805
                I  +  +I +K   S+ Q  I     L E  R   R++    L C  E  S S  
Sbjct: 344 ---LIIQGVLSDINLKKGESECQYYIDKLEYLDEKQRD-PRIEASKVLLCHGELRSKS-- 397

Query: 806 LYEHIHDLSLFLFNDALLVSSRGTSHTPFERTSKTTYQ-FIASVALHRLLIENIPD 860
                H L +FLF D L+++       P  R  + +YQ +   + +  L++E++ D
Sbjct: 398 ----GHKLYIFLFQDILVLT------RPVTRNERHSYQVYRQPIPVQELVLEDLQD 443


>gi|19923327 neuroepithelial cell transforming gene 1 isoform 2
           [Homo sapiens]
          Length = 542

 Score = 65.5 bits (158), Expect = 2e-10
 Identities = 72/296 (24%), Positives = 128/296 (43%), Gaps = 27/296 (9%)

Query: 566 KRARVVRELLQSERKYVQILEIVRDVYVAPLKAALSSNRAILSAANIQIIFCDILQILSL 625
           +R   + E+ + E+  ++ L++ R  Y  P+        +I+S   +  IF D+   + L
Sbjct: 120 RRQEAIYEMSRGEQDLIEDLKLARKAYHDPMLKL-----SIMSEEELTHIFGDLDSYIPL 174

Query: 626 NRQFLDNLRDRLQEWGPAHCVGEIVTKFGSQLNTYTNFFNNYPVILKTIEKCREMIPAFR 685
           +   L  + +  +  G    +G I+  +  +LN Y  + +N  +  K +   ++  P  +
Sbjct: 175 HEDLLTRIGEATKPDGTVEQIGHILVSWLPRLNAYRGYCSNQ-LAAKALLDQKKQDPRVQ 233

Query: 686 TFLKRHDKTIVTKMLSLPELLLYPSRRFEEYLNLLYAVRLHTPAEHVDRGDLTTAIDQIK 745
            FL+R  ++  ++ L L   L  P  R  +Y  LL  +  HTP EH D   L  AI    
Sbjct: 234 DFLQRCLESPFSRKLDLWSFLDIPRSRLVKYPLLLKEILKHTPKEHPDVQLLEDAI---- 289

Query: 746 KYKGYIDQMKQNITMKDHLSDIQRIIWGCPTLSEVNRYLIRVQDVAQLHCCDEEISFSLR 805
                I  +  +I +K   S+ Q  I     L E  R   R++    L C  E  S S  
Sbjct: 290 ---LIIQGVLSDINLKKGESECQYYIDKLEYLDEKQRD-PRIEASKVLLCHGELRSKS-- 343

Query: 806 LYEHIHDLSLFLFNDALLVSSRGTSHTPFERTSKTTYQ-FIASVALHRLLIENIPD 860
                H L +FLF D L+++       P  R  + +YQ +   + +  L++E++ D
Sbjct: 344 ----GHKLYIFLFQDILVLT------RPVTRNERHSYQVYRQPIPVQELVLEDLQD 389


>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
          Length = 1721

 Score = 64.7 bits (156), Expect = 4e-10
 Identities = 74/351 (21%), Positives = 151/351 (43%), Gaps = 25/351 (7%)

Query: 566  KRARVVRELLQSERKYVQILEIVRDVYVAPLKAALSSNRAILSAANIQIIFCDILQILSL 625
            KR   + EL+ +E  YV  L++V +++  PL  +      +L+   + +IF +  +++  
Sbjct: 1237 KRQGYIHELIVTEENYVNDLQLVTEIFQKPLMES-----ELLTEKEVAMIFVNWKELIMC 1291

Query: 626  NRQFLDNLRDRLQEWG---PAHCVGEIVTKFGSQLNTYTNFFNNYPVILKTIEKCREMIP 682
            N + L  LR R +  G   P   +G+I++     +  Y  F +        I++  +  P
Sbjct: 1292 NIKLLKALRVRKKMSGEKMPVKMIGDILSAQLPHMQPYIRFCSRQLNGAALIQQKTDEAP 1351

Query: 683  AFRTFLKRHDKTIVTKMLSLPELLLYPSRRFEEYLNLLYAVRLHTPAEHVDRGDLTTAID 742
             F+ F+KR       K + L   +L P +R   Y  ++  +  +TP  H D   L  A++
Sbjct: 1352 DFKEFVKRLAMDPRCKGMPLSSFILKPMQRVTRYPLIIKNILENTPENHPDHSHLKHALE 1411

Query: 743  QIKKYKGYIDQMKQNITMKDHLSDIQRIIWGCPTLSEVNRYLIRVQDVAQLHCC-DEEIS 801
            + ++    +++  +     D L  IQ  +  C  LSE      ++   +  +C    +  
Sbjct: 1412 KAEELCSQVNEGVREKENSDRLEWIQAHV-QCEGLSE------QLVFNSVTNCLGPRKFL 1464

Query: 802  FSLRLYEHIHDLSL--FLFNDALLVS-------SRGTSHTPFERTSKTTYQFIASVALHR 852
             S +LY+   +  L  FLFND LL++       S GT      +++     +   + L+ 
Sbjct: 1465 HSGKLYKAKSNKELYGFLFNDFLLLTQITKPLGSSGTDKVFSPKSNLQYKMYKTPIFLNE 1524

Query: 853  LLIENIPDSKYVKNAFILQGPKYKWICATEIEDDKFLWLSVLRNAIKSSME 903
            +L++   D    +  F +      +    E  +++  W+  ++ A +  +E
Sbjct: 1525 VLVKLPTDPSGDEPIFHISHIDRVYTLRAESINERTAWVQKIKAASELYIE 1575


>gi|120432044 vav 3 guanine nucleotide exchange factor isoform 1
           [Homo sapiens]
          Length = 847

 Score = 63.9 bits (154), Expect = 6e-10
 Identities = 68/325 (20%), Positives = 142/325 (43%), Gaps = 27/325 (8%)

Query: 505 LNNQDTAQALADGLMELSKEDSERNVVEDNSWDTKSRLSKNDLNFEALINLERILQKDSA 564
           +N++D  + L D + E   ED      E++ +D      +    +E L+  E   Q    
Sbjct: 135 INDEDIYKGLPDLIDETLVED------EEDLYDCVYGEDEGGEVYEDLMKAEEAHQPKCP 188

Query: 565 EK--RARVVRELLQSERKYVQILEIVRDVYVAPLKAALSSNRAILSAANIQIIFCDILQI 622
           E   R+  + E+ Q+E KY + LE +   ++APLK         L+AA    +F +I ++
Sbjct: 189 ENDIRSCCLAEIKQTEEKYTETLESIEKYFMAPLK-------RFLTAAEFDSVFINIPEL 241

Query: 623 LSLNRQFLDNLRDRLQEWGPAHCVGEIVTKFGSQLNTYTNFFNNYPVILKTIEKCREMIP 682
           + L+R  +  + D +      + + ++   +  +L  Y  + +     + +++   +   
Sbjct: 242 VKLHRNLMQEIHDSIVNKNDQN-LYQVFINYKERLVIYGQYCSGVESAISSLDYISKTKE 300

Query: 683 AFRTFLKRHDKTIVTKMLSLPELLLYPSRRFEEYLNLLYAVRLHTPAEHVDRGDLTTAID 742
             +  L+   K       +L +LL+ P +R  +Y  LL  +  HT  +  ++ +L  A+D
Sbjct: 301 DVKLKLEECSKRANNGKFTLRDLLVVPMQRVLKYHLLLQELVKHT-TDPTEKANLKLALD 359

Query: 743 QIKKYKGYIDQMKQNITMKDHLSDIQRIIWGCPTLSEVNRYLIRVQDVAQLHCCDEEISF 802
            +K    Y++++K++    + L +I++       L++      R Q        D EI  
Sbjct: 360 AMKDLAQYVNEVKRD---NETLREIKQFQLSIENLNQPVLLFGRPQG-------DGEIRI 409

Query: 803 SLRLYEHIHDLSLFLFNDALLVSSR 827
           +        +  +FLF+ A++V  R
Sbjct: 410 TTLDKHTKQERHIFLFDLAVIVCKR 434


>gi|194294523 intersectin 2 isoform 3 [Homo sapiens]
          Length = 1670

 Score = 63.2 bits (152), Expect = 1e-09
 Identities = 58/263 (22%), Positives = 114/263 (43%), Gaps = 12/263 (4%)

Query: 566  KRARVVRELLQSERKYVQILEIVRDVYVAPLKAALSSNRAILSAANIQIIFCDILQILSL 625
            KR   + EL+Q+E +Y+  L++V +V+   +     +    L+   + +IF +  +++  
Sbjct: 1182 KRQGYIHELIQTEERYMADLQLVVEVFQKRM-----AESGFLTEGEMALIFVNWKELIMS 1236

Query: 626  NRQFLDNLRDRLQEWG---PAHCVGEIVTKFGSQLNTYTNFFNNYPVILKTIEKCREMIP 682
            N + L  LR R +  G   P   +G+I+    S +  Y  F +        +++  +   
Sbjct: 1237 NTKLLKALRVRKKTGGEKMPVQMIGDILAAELSHMQAYIRFCSCQLNGAALLQQKTDEDT 1296

Query: 683  AFRTFLKRHDKTIVTKMLSLPELLLYPSRRFEEYLNLLYAVRLHTPAEHVDRGDLTTAID 742
             F+ FLK+       K + L   LL P +R   Y  L+ ++  +TP  H D   L  A++
Sbjct: 1297 DFKEFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSILENTPESHADHSSLKLALE 1356

Query: 743  QIKKYKGYIDQMKQNITMKDHLSDIQRIIWGCPTLSEVNRYLIRVQDVAQLHCCDEEISF 802
            + ++    +++  +     D L  IQ  +  C  L+E   +      +           +
Sbjct: 1357 RAEELCSQVNEGVREKENSDRLEWIQAHV-QCEGLAEQLIFNSLTNCLGPRKLLHSGKLY 1415

Query: 803  SLRLYEHIHDLSLFLFNDALLVS 825
              +  + +H    FLFND LL++
Sbjct: 1416 KTKSNKELHG---FLFNDFLLLT 1435


>gi|194294521 intersectin 2 isoform 1 [Homo sapiens]
          Length = 1697

 Score = 63.2 bits (152), Expect = 1e-09
 Identities = 58/263 (22%), Positives = 114/263 (43%), Gaps = 12/263 (4%)

Query: 566  KRARVVRELLQSERKYVQILEIVRDVYVAPLKAALSSNRAILSAANIQIIFCDILQILSL 625
            KR   + EL+Q+E +Y+  L++V +V+   +     +    L+   + +IF +  +++  
Sbjct: 1209 KRQGYIHELIQTEERYMADLQLVVEVFQKRM-----AESGFLTEGEMALIFVNWKELIMS 1263

Query: 626  NRQFLDNLRDRLQEWG---PAHCVGEIVTKFGSQLNTYTNFFNNYPVILKTIEKCREMIP 682
            N + L  LR R +  G   P   +G+I+    S +  Y  F +        +++  +   
Sbjct: 1264 NTKLLKALRVRKKTGGEKMPVQMIGDILAAELSHMQAYIRFCSCQLNGAALLQQKTDEDT 1323

Query: 683  AFRTFLKRHDKTIVTKMLSLPELLLYPSRRFEEYLNLLYAVRLHTPAEHVDRGDLTTAID 742
             F+ FLK+       K + L   LL P +R   Y  L+ ++  +TP  H D   L  A++
Sbjct: 1324 DFKEFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSILENTPESHADHSSLKLALE 1383

Query: 743  QIKKYKGYIDQMKQNITMKDHLSDIQRIIWGCPTLSEVNRYLIRVQDVAQLHCCDEEISF 802
            + ++    +++  +     D L  IQ  +  C  L+E   +      +           +
Sbjct: 1384 RAEELCSQVNEGVREKENSDRLEWIQAHV-QCEGLAEQLIFNSLTNCLGPRKLLHSGKLY 1442

Query: 803  SLRLYEHIHDLSLFLFNDALLVS 825
              +  + +H    FLFND LL++
Sbjct: 1443 KTKSNKELHG---FLFNDFLLLT 1462


>gi|134133248 FYVE, RhoGEF and PH domain containing 3 [Homo sapiens]
          Length = 725

 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 72/344 (20%), Positives = 132/344 (38%), Gaps = 25/344 (7%)

Query: 558 ILQKDSAEKRARVVRELLQSERKYVQILEIVRDVYVAPLKAALSSNRAILSAANIQIIFC 617
           + Q    +K   + +ELL +E  YV+ L ++  V+   L  A      I+       IF 
Sbjct: 149 LAQHSGPQKLLHIAQELLHTEETYVKRLHLLDQVFCTRLTDAGIPPEVIMG------IFS 202

Query: 618 DILQILSLNRQFL-DNLRDRL-QEWGPAHCVGEIVTKFGSQLNTYTNFFNNYPVILKTIE 675
           +I  I   + QFL   L+ R+ +EW     +G+I+ K    L  Y  +  N+   +  + 
Sbjct: 203 NISSIHRFHGQFLLPELKTRITEEWDTNPRLGDILQKLAPFLKMYGEYVKNFDRAVGLVS 262

Query: 676 KCREMIPAFRTFLKRHDKTIVTKMLSLPELLLYPSRRFEEYLNLLYAVRLHTPAEHVDRG 735
              +  P F+  +    K  V   L+L   +L P +R   Y  LL       P +  DR 
Sbjct: 263 TWTQRSPLFKDVVHSIQKQEVCGNLTLQHHMLEPVQRVPRYELLLKDYLKRLPQDAPDRK 322

Query: 736 DLTTAIDQIKKYKGYIDQMKQNITMKDHLSDIQRIIWGCPTLSEVNRYLIRVQDVAQLHC 795
           D   +++ I     + +   + +     L ++   + G   +      LI+   + +L  
Sbjct: 323 DAERSLELISTAANHSNAAIRKVEKMHKLLEVYEQLGGEEDIVNPANELIKEGQIQKLSA 382

Query: 796 CDEEISFSLRLYEHIHDLSLFLFNDALLVSSRGTSHTPFERTSKTTYQFIASVALHRLLI 855
            +              D  LFLFN  +L         P  R     +     + +  L +
Sbjct: 383 KNGT----------PQDRHLFLFNSMILYC------VPKLRLMGQKFSVREKMDISGLQV 426

Query: 856 ENIPDSKYVKNAFILQGPKYKWICATEIEDDKFLWLSVLRNAIK 899
           ++I       + FI+ G K      T  E++K  W+ +++  I+
Sbjct: 427 QDIVKPN-TAHTFIITGRKRSLELQTRTEEEKKEWIQIIQATIE 469


>gi|134133265 FYVE, RhoGEF and PH domain containing 3 [Homo sapiens]
          Length = 725

 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 72/344 (20%), Positives = 132/344 (38%), Gaps = 25/344 (7%)

Query: 558 ILQKDSAEKRARVVRELLQSERKYVQILEIVRDVYVAPLKAALSSNRAILSAANIQIIFC 617
           + Q    +K   + +ELL +E  YV+ L ++  V+   L  A      I+       IF 
Sbjct: 149 LAQHSGPQKLLHIAQELLHTEETYVKRLHLLDQVFCTRLTDAGIPPEVIMG------IFS 202

Query: 618 DILQILSLNRQFL-DNLRDRL-QEWGPAHCVGEIVTKFGSQLNTYTNFFNNYPVILKTIE 675
           +I  I   + QFL   L+ R+ +EW     +G+I+ K    L  Y  +  N+   +  + 
Sbjct: 203 NISSIHRFHGQFLLPELKTRITEEWDTNPRLGDILQKLAPFLKMYGEYVKNFDRAVGLVS 262

Query: 676 KCREMIPAFRTFLKRHDKTIVTKMLSLPELLLYPSRRFEEYLNLLYAVRLHTPAEHVDRG 735
              +  P F+  +    K  V   L+L   +L P +R   Y  LL       P +  DR 
Sbjct: 263 TWTQRSPLFKDVVHSIQKQEVCGNLTLQHHMLEPVQRVPRYELLLKDYLKRLPQDAPDRK 322

Query: 736 DLTTAIDQIKKYKGYIDQMKQNITMKDHLSDIQRIIWGCPTLSEVNRYLIRVQDVAQLHC 795
           D   +++ I     + +   + +     L ++   + G   +      LI+   + +L  
Sbjct: 323 DAERSLELISTAANHSNAAIRKVEKMHKLLEVYEQLGGEEDIVNPANELIKEGQIQKLSA 382

Query: 796 CDEEISFSLRLYEHIHDLSLFLFNDALLVSSRGTSHTPFERTSKTTYQFIASVALHRLLI 855
            +              D  LFLFN  +L         P  R     +     + +  L +
Sbjct: 383 KNGT----------PQDRHLFLFNSMILYC------VPKLRLMGQKFSVREKMDISGLQV 426

Query: 856 ENIPDSKYVKNAFILQGPKYKWICATEIEDDKFLWLSVLRNAIK 899
           ++I       + FI+ G K      T  E++K  W+ +++  I+
Sbjct: 427 QDIVKPN-TAHTFIITGRKRSLELQTRTEEEKKEWIQIIQATIE 469


>gi|154240686 FYVE, RhoGEF and PH domain containing 6 [Homo sapiens]
          Length = 1430

 Score = 60.8 bits (146), Expect = 5e-09
 Identities = 78/386 (20%), Positives = 155/386 (40%), Gaps = 36/386 (9%)

Query: 525  DSERNVVEDNSWDTKSRLSKNDLNFEALINLERILQKDSAEKRA--RVVRELLQSERKYV 582
            D E  +   +  D  S  SK + +      LE    +D+  K     + +E++ SE+ +V
Sbjct: 833  DEEEIINSSDEDDVSSESSKGEPD-----PLEDKQDEDNGMKSKVHHIAKEIMSSEKVFV 887

Query: 583  QILEIVR-DVYVAPLKAALSSNRAILSAANIQIIFCDILQILSLNRQFLDNLRDRLQEWG 641
             +L+++  D   A   A+    + ++    +  I   + Q+  LNR  L  L +R+  W 
Sbjct: 888  DVLKLLHIDFRDAVAHASRQLGKPVIEDRILNQILYYLPQLYELNRDLLKELEERMLHWT 947

Query: 642  PAHCVGEIVTKFGSQLNTYTNFFNNYPVILKTIEKCREMIPAFRTFLKRHDKTIVTKMLS 701
                + +I  K G  L  Y+ +   +   +  +++  +  P F   ++  + +     L+
Sbjct: 948  EQQRIADIFVKKGPYLKMYSTYIKEFDKNIALLDEQCKKNPGFAAVVREFEMSPRCANLA 1007

Query: 702  LPELLLYPSRRFEEYLNLL--YAVRLHTPA-EHVDRGDLTTAIDQIKKYKGYIDQMKQNI 758
            L   LL P +R  +Y  LL  Y   L   A ++ D  D    + ++  +    D MKQ  
Sbjct: 1008 LKHYLLKPVQRIPQYRLLLTDYLKNLIEDAGDYRDTQDALAVVIEVANHAN--DTMKQGD 1065

Query: 759  TMKDHLSDIQRIIWGCPTLSEVNRYLIRVQDVAQLHCCDEEISFSLRLYEHIHDLSLFLF 818
              +  L  IQ  + G   + +  R  ++   + +L              + +     FLF
Sbjct: 1066 NFQK-LMQIQYSLNGHHEIVQPGRVFLKEGILMKLS------------RKVMQPRMFFLF 1112

Query: 819  NDALLVSSRGTSHTPFERTSKTTYQFIASVALHRLLIENIPDSKYVKNAFILQGPKYKWI 878
            NDALL +      TP +      Y+    ++L  + +   P  +  +N   ++  +  +I
Sbjct: 1113 NDALLYT------TPVQ---SGMYKLNNMLSLAGMKVRK-PTQEAYQNELKIESVERSFI 1162

Query: 879  CATEIEDDKFLWLSVLRNAIKSSMEK 904
             +     ++  WL  +  AI+   +K
Sbjct: 1163 LSASSATERDEWLEAISRAIEEYAKK 1188


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.322    0.135    0.411 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 31,801,979
Number of Sequences: 37866
Number of extensions: 1356344
Number of successful extensions: 3888
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 56
Number of HSP's successfully gapped in prelim test: 74
Number of HSP's that attempted gapping in prelim test: 3726
Number of HSP's gapped (non-prelim): 176
length of query: 904
length of database: 18,247,518
effective HSP length: 111
effective length of query: 793
effective length of database: 14,044,392
effective search space: 11137202856
effective search space used: 11137202856
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.