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Search of human proteins with 239751461
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|239751461 PREDICTED: hypothetical protein XP_002347871 [Homo
sapiens]
(559 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|239751461 PREDICTED: hypothetical protein XP_002347871 [Homo ... 1123 0.0
gi|160420295 hypothetical protein LOC85459 [Homo sapiens] 215 8e-56
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 56 8e-08
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 56 8e-08
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 56 8e-08
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 56 8e-08
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 56 8e-08
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 56 8e-08
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 56 8e-08
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 56 8e-08
gi|148746195 trichohyalin [Homo sapiens] 45 1e-04
gi|239743649 PREDICTED: IQ motif and ankyrin repeat domain-conta... 44 3e-04
gi|75750474 spectrin domain with coiled-coils 1 NSP5a3b [Homo sa... 44 5e-04
gi|75750468 spectrin domain with coiled-coils 1 NSP5a3a [Homo sa... 44 5e-04
gi|32484977 angiomotin like 2 [Homo sapiens] 43 7e-04
gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens] 43 9e-04
gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens] 43 9e-04
gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens] 43 9e-04
gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens] 43 9e-04
gi|91208420 bassoon protein [Homo sapiens] 42 0.001
gi|4827046 U2 small nuclear RNA auxiliary factor 1-like 2 [Homo ... 42 0.001
gi|102467235 inner centromere protein antigens 135/155kDa isofor... 41 0.003
gi|102467242 inner centromere protein antigens 135/155kDa isofor... 41 0.003
gi|21735548 centrosomal protein 2 [Homo sapiens] 40 0.004
gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens] 40 0.004
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens] 40 0.004
gi|239757626 PREDICTED: hypothetical protein XP_002345507 [Homo ... 40 0.006
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 40 0.006
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 40 0.006
gi|42542379 serine/arginine repetitive matrix 1 [Homo sapiens] 40 0.006
>gi|239751461 PREDICTED: hypothetical protein XP_002347871 [Homo
sapiens]
Length = 559
Score = 1123 bits (2905), Expect = 0.0
Identities = 559/559 (100%), Positives = 559/559 (100%)
Query: 1 MWLSLCPDNEDLLWRKKHKLLQARGKGDLALQRRADAKLWKNYQLQRLAEELRRGYQEAQ 60
MWLSLCPDNEDLLWRKKHKLLQARGKGDLALQRRADAKLWKNYQLQRLAEELRRGYQEAQ
Sbjct: 1 MWLSLCPDNEDLLWRKKHKLLQARGKGDLALQRRADAKLWKNYQLQRLAEELRRGYQEAQ 60
Query: 61 HLHVGGLDRLQSARLLGWGGGRARENEPDSQGPIQRRSARPPRAKEKHRAALSEERSCRE 120
HLHVGGLDRLQSARLLGWGGGRARENEPDSQGPIQRRSARPPRAKEKHRAALSEERSCRE
Sbjct: 61 HLHVGGLDRLQSARLLGWGGGRARENEPDSQGPIQRRSARPPRAKEKHRAALSEERSCRE 120
Query: 121 ELGQQHPRHSRPRKTAASPEKPQTTKATGRMNSHLAPPEKRKGRPEPSTKSGGGRCAIHP 180
ELGQQHPRHSRPRKTAASPEKPQTTKATGRMNSHLAPPEKRKGRPEPSTKSGGGRCAIHP
Sbjct: 121 ELGQQHPRHSRPRKTAASPEKPQTTKATGRMNSHLAPPEKRKGRPEPSTKSGGGRCAIHP 180
Query: 181 RRSKGADLERSNPLVAAVGEIGLVEEKEKGTARAGRRQLGKGAVCFVPALTSRSQGQSLE 240
RRSKGADLERSNPLVAAVGEIGLVEEKEKGTARAGRRQLGKGAVCFVPALTSRSQGQSLE
Sbjct: 181 RRSKGADLERSNPLVAAVGEIGLVEEKEKGTARAGRRQLGKGAVCFVPALTSRSQGQSLE 240
Query: 241 GKLRDLGQLWPADSSCRREAVSPASQCTLREKNKWQKELELAFEELFNINRKLKKHLCLY 300
GKLRDLGQLWPADSSCRREAVSPASQCTLREKNKWQKELELAFEELFNINRKLKKHLCLY
Sbjct: 241 GKLRDLGQLWPADSSCRREAVSPASQCTLREKNKWQKELELAFEELFNINRKLKKHLCLY 300
Query: 301 LALKPRMDQRPGEGHAFSEMQECGAGTPRGKKMADPEMLPAGEPRSPAEEEAQQAASKTD 360
LALKPRMDQRPGEGHAFSEMQECGAGTPRGKKMADPEMLPAGEPRSPAEEEAQQAASKTD
Sbjct: 301 LALKPRMDQRPGEGHAFSEMQECGAGTPRGKKMADPEMLPAGEPRSPAEEEAQQAASKTD 360
Query: 361 LKTFMGKAQNQKYQGTVKPTFRNGSQTLSPEAGIFINKEDSLLYSTESGQETPKLGTLAE 420
LKTFMGKAQNQKYQGTVKPTFRNGSQTLSPEAGIFINKEDSLLYSTESGQETPKLGTLAE
Sbjct: 361 LKTFMGKAQNQKYQGTVKPTFRNGSQTLSPEAGIFINKEDSLLYSTESGQETPKLGTLAE 420
Query: 421 GSLQLHLQDQADRVGSTASRQRQKAEMEQRRQKQLESLEQMEHPDMSLEIHYKAELEKER 480
GSLQLHLQDQADRVGSTASRQRQKAEMEQRRQKQLESLEQMEHPDMSLEIHYKAELEKER
Sbjct: 421 GSLQLHLQDQADRVGSTASRQRQKAEMEQRRQKQLESLEQMEHPDMSLEIHYKAELEKER 480
Query: 481 REQRRARLAHLKSSSTRAQERERGSELSTTSPSGTSLADDDRHSQMIRDQQQQILQQNRL 540
REQRRARLAHLKSSSTRAQERERGSELSTTSPSGTSLADDDRHSQMIRDQQQQILQQNRL
Sbjct: 481 REQRRARLAHLKSSSTRAQERERGSELSTTSPSGTSLADDDRHSQMIRDQQQQILQQNRL 540
Query: 541 HKQFLEEARKCLREFQNIC 559
HKQFLEEARKCLREFQNIC
Sbjct: 541 HKQFLEEARKCLREFQNIC 559
>gi|160420295 hypothetical protein LOC85459 [Homo sapiens]
Length = 2601
Score = 215 bits (548), Expect = 8e-56
Identities = 189/619 (30%), Positives = 297/619 (47%), Gaps = 103/619 (16%)
Query: 10 EDLLWRKKHKLLQARGKG-DLALQRRADAKLWKNYQLQRLAEELRRGYQEAQHLHVGGLD 68
ED R+K +LLQ R + D+ALQ R D K +N Q RLAEELR ++E+Q + L+
Sbjct: 24 EDYERRRKLRLLQVREQERDIALQIREDIKQRRNQQFTRLAEELRAEWEESQTQKIQNLE 83
Query: 69 RLQ--SARLLGWGGGRARENEPDSQGPIQRRSARPPRAKEKHRAALSEERSCREELGQQH 126
+L S R +G G +A+ENEPD QR + R +A +H+ AL +++ +E L +Q
Sbjct: 84 KLYLASLRSMGEGHRQAKENEPDLDALAQRAAERKRKADLRHKEALKVQKNQKEILLKQK 143
Query: 127 PRHSRPRKTAASPEKPQTTKATGRMNSHLAPP-----EKRKGRPEPSTKSGGGRC-AIHP 180
H + RK A EK ++ K T L PP E + + + K+ +H
Sbjct: 144 TWHIKARKEALLVEKERSAKITS-----LPPPPPTLFENIEVKRISAVKTNSSTYHHLHT 198
Query: 181 RRSKGADLERSNPLVAAVGEIGLVEEKEKGTARAGRRQLGKGAVCFVPALTSRSQGQSLE 240
++ D +R + +AA E +EE +K A+ + K V A+ Q+ E
Sbjct: 199 FVNRETDTKRPDARLAAEEEAKRLEELQKQAAQERMERFEKAHVRGFQAMKKIHLAQNQE 258
Query: 241 GKLRDLGQLWPADSSCRREAVS--PASQCTL-----REKNKWQKELELAFEELFNINRKL 293
+++L QL D + RR+ V+ P L K WQ+ELE AFE+++N +RK+
Sbjct: 259 KLMKELKQLQQEDLARRRQTVAQMPPQLVELPYKRSEMKEDWQRELEFAFEDMYNADRKV 318
Query: 294 KKHLCLYLALK--PRMDQRPGEGHAFSEMQECGAGTPRGKKMADPEMLPAGEPRSPAEEE 351
K +L L+L + P + + + M++ G + + E+ + E P +
Sbjct: 319 KGNLILHLEPEPLPTVTNQIQDEELDLSMEQENLGAAEDLPVTEAEIC-SSETDVPLVMK 377
Query: 352 AQQAASKTDLKTFMGKAQNQKYQGTVK--------------------PTFRNG------- 384
QQ SK K + K ++QK T+K PT +G
Sbjct: 378 TQQIPSKVLFKKLLNKIRSQKSLWTIKSMSEDESEMITTVSEIESKAPTVESGTIASKER 437
Query: 385 -----------SQTLSPEAGIFINKEDSLLYSTESGQ-----ETPKLGTLAEGSLQLHLQ 428
S TL+ E+G +++ L T SG+ ET + T+A+ S+ LH Q
Sbjct: 438 TLSSGQEQVVESDTLTIESGPLASEDKPLSCGTNSGKEQEINETLPITTVAQSSVLLHPQ 497
Query: 429 DQADRVGSTASRQRQKAEMEQRRQKQLESLEQMEHPDMSLEIH-YKAELEKERREQRRAR 487
+ A R+ +A RQ+Q E+E+++QKQLE LEQ+E + LE ++A+LE+E+R++
Sbjct: 498 EAAARIRMSA-RQKQIMEIEEQKQKQLELLEQIEQQKLRLETDCFRAQLEEEKRKK---- 552
Query: 488 LAHLKSSSTRAQERERGSELSTTSPSGTSLA--------DDDRHSQMIRDQQQQILQQNR 539
T P+G +A D+D H QMIR+ Q Q+LQQNR
Sbjct: 553 ----------------------TQPTGVGIAPASCPVISDEDSHRQMIRNYQHQLLQQNR 590
Query: 540 LHKQFLEEARKCLREFQNI 558
LH+Q +E ARK L E+Q +
Sbjct: 591 LHRQSVETARKQLLEYQTM 609
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 56.2 bits (134), Expect = 8e-08
Identities = 125/587 (21%), Positives = 229/587 (39%), Gaps = 95/587 (16%)
Query: 31 LQRRADAKLWKNYQLQRLAEELRRGYQEAQH-LHVGGLDRLQSARLLGWGGGRARENEPD 89
++ A+A K LQ L EELR +EA+ L ++R + ++ R+ E E
Sbjct: 1521 VKAEAEAAREKQRALQAL-EELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQ 1579
Query: 90 SQ-GPIQRRSARPPRAKEKHRAALSEERSCREELGQQHPRHSRPRKTAASPEKPQTTKAT 148
S+ ++A+ R+ ++ A+++ R E QQ R R+ A + KA
Sbjct: 1580 SKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKAN 1639
Query: 149 GRMNSHL-------------APPEKRKGRPEPSTKSGGG--RCAIHPRRSKGADLERSNP 193
+ L A EK+K E + G A+ R +LE+
Sbjct: 1640 EALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ 1699
Query: 194 LVAAVGEIGLVEEKEKGTARAG------RRQLGKGAVCFVP--ALTSRSQGQSLEGKLRD 245
L + L E+E RA +RQL + + + A + + Q LE +L
Sbjct: 1700 LAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAK 1759
Query: 246 LG-------------------------QLWPADSSCRREAVSPASQC-TLREKNKWQKEL 279
+ Q A++ RE A++ L E+ K Q++L
Sbjct: 1760 VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQL 1819
Query: 280 ELAFEELFNINRKLKKHLCLYLALKPRMDQRPGEGHAFSEMQECGAGTPRGKKMADPEML 339
A E+ + ++ L LA + E ++E A R +++A+ E
Sbjct: 1820 --AEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEI--ALKEKEAENERLRRLAEDE-- 1873
Query: 340 PAGEPRSPAEEEAQQAASKTDLKTFMGKAQN---QKYQGTVKPTFRNGSQTLSPEAGIFI 396
A + R E+ AQ A + + KA + ++ +G V+ T R Q
Sbjct: 1874 -AFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQV--------- 1923
Query: 397 NKEDSLLYSTESGQETPKLGTLAEGSLQLHLQDQADRVGSTAS---RQRQKAEMEQRRQK 453
E+ +L S ++ A G +L L+ R+ S A R +++AE+E RQ+
Sbjct: 1924 --EEEILALKASFEKA------AAGKAELELE--LGRIRSNAEDTLRSKEQAELEAARQR 1973
Query: 454 QLESLEQMEHPDMSLEIHYKAELEKERREQRRARLAHLKSSSTRAQE----RERGS---- 505
QL + E+ + + E+E QR+A L ++ + +E RER
Sbjct: 1974 QLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESA 2033
Query: 506 ---ELSTTSPSGTSLADDDRHSQMIRDQQQQILQQNRLHKQFLEEAR 549
+L+ + A++ H+ ++ ++Q++ Q + + L++ R
Sbjct: 2034 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR 2080
Score = 35.4 bits (80), Expect = 0.14
Identities = 69/303 (22%), Positives = 118/303 (38%), Gaps = 45/303 (14%)
Query: 206 EKEKGTARAGRRQLGKGAVCFVPALTSRSQG--QSLEG-KLRDLGQLWPADSSCRREAVS 262
+++K A+ R+L + L +QG ++LE + R L A+ R A
Sbjct: 2333 QQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEM 2392
Query: 263 PASQCTLREK-NKWQKELELAFEELFNINRKLKKHLCLYLALKPRMDQRPGEGHAFSEMQ 321
+Q E +++K+ E E+L ++ + L L+ QR H ++
Sbjct: 2393 SRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI---QRQQSDHDAERLR 2449
Query: 322 ECGAGTPRGKKMADPEMLPAGEPRSPAEEEAQQAASKTDLKTFMGKAQNQKYQGTVKPTF 381
E A R K E+ QQ A LK+ ++ Q +
Sbjct: 2450 EAIAELEREK------------------EKLQQEAKLLQLKS-------EEMQTVQQEQL 2484
Query: 382 RNGSQTLSPEAGIFINKEDSLLYSTES-GQETPKLGTLAEGSLQLHLQDQADRVGSTASR 440
+Q L F++++DSLL QE KL QL + A +
Sbjct: 2485 LQETQALQQS---FLSEKDSLLQRERFIEQEKAKLE-------QLFQDEVAKAQQLREEQ 2534
Query: 441 QRQKAEMEQRRQKQLESLEQMEHPDMSLE--IHYKAELEKERREQRRARLAHLKSSSTRA 498
QRQ+ +MEQ RQ+ + S+E+ E + K E ++ +QRR + L + R
Sbjct: 2535 QRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRL 2594
Query: 499 QER 501
+E+
Sbjct: 2595 REQ 2597
Score = 34.3 bits (77), Expect = 0.31
Identities = 32/108 (29%), Positives = 50/108 (46%), Gaps = 4/108 (3%)
Query: 419 AEGSLQLHLQDQADRVGSTASRQRQKAEMEQRRQKQLESLEQMEHPDMSLEIHYKAELEK 478
AEG LQ L+ +A+ RQ Q+ RRQ Q ES ++ ++ L KAE E
Sbjct: 1471 AEGELQA-LRARAEEA-EAQKRQAQEEAERLRRQVQDES-QRKRQAEVELASRVKAEAEA 1527
Query: 479 ERREQRRAR-LAHLKSSSTRAQERERGSELSTTSPSGTSLADDDRHSQ 525
R +QR + L L+ + A+ R R +E+ +L R ++
Sbjct: 1528 AREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1575
Score = 32.3 bits (72), Expect = 1.2
Identities = 118/575 (20%), Positives = 218/575 (37%), Gaps = 74/575 (12%)
Query: 10 EDLLWRKKHKLLQARGKGDLALQRRADAKLWKNYQLQRLAEELRRGYQEAQHLHVGGLDR 69
+ L +++ L Q RG+ + A +R A+ Q +R A + RR +EA+ L ++
Sbjct: 2066 QQTLQQEQSVLDQLRGEAEAA-RRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQ 2124
Query: 70 LQSARLLGWGGGRARENEPDSQGPIQRRSARPPRAKEKHRAALSEERSCREELGQQHPRH 129
Q AR E + + R A+ +A + + A E ++ +Q R
Sbjct: 2125 AQ-ARAQAQAAAEKLRKEAEQEAA---RRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ 2180
Query: 130 SRPRKTAASPEKPQTTKATGRMNSHLAPPEKRKGRPEPSTKSGGGRCAIHPR----RSKG 185
+ + + Q + + N L E ++ + E +T++ R + R +
Sbjct: 2181 KAQVEQELTTLRLQLEETDHQKN--LLDEELQRLKAE-ATEAARQRSQVEEELFSVRVQM 2237
Query: 186 ADLERSNPLVAAVGEIGLVEEKE------KGTARAGRRQLGKGAVCFVPALTSRSQGQSL 239
+L + + A ++ +K+ + A ++ + A V A + Q
Sbjct: 2238 EELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLA 2297
Query: 240 EGKLRDLGQLWPADSSCRREAVSPASQCTLREKNKWQKELELAFEELFNINRKLKKHLCL 299
E L L + +AV A++ E Q++ ELA E+ + K+ +
Sbjct: 2298 EEDLAQQRALAEKMLKEKMQAVQEATRLKA-EAELLQQQKELAQEQARRLQED-KEQMAQ 2355
Query: 300 YLALKPRMDQRPGEGHAFSEMQECGAGTPRGKKMADPEMLPAGEPRSPAEEEAQQ---AA 356
LA + + QR E ++ E A R K+ EM A ++ AEE+AQ+ A
Sbjct: 2356 QLAEETQGFQRTLEAERQRQL-EMSAEAER-LKLRVAEMSRA---QARAEEDAQRFRKQA 2410
Query: 357 SKTDLKTFMGKAQNQKYQGTVKPTFRNGSQTLSPEAGIFINKEDSLLYSTESGQETPKLG 416
+ K + Q+ + T+ T Q +A L E Q+ KL
Sbjct: 2411 EEIGEKLHRTELATQE-KVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL 2469
Query: 417 TLAEGSLQLHLQDQA------------DRVGSTASRQR----QKAEMEQRRQKQLESLEQ 460
L +Q Q+Q S R+R +KA++EQ Q ++ +Q
Sbjct: 2470 QLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQ 2529
Query: 461 MEHPDMSLEIHYKAELEKERREQRRARL-AHLKSSSTRAQERERGSELSTTSPSGTSLAD 519
+ + + ++++ EQ R RL A ++ + R E E G
Sbjct: 2530 LRE---------EQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRK----------- 2569
Query: 520 DDRHSQMIRDQQQQILQQNRLHKQFLEEARKCLRE 554
+++ QQ+ QQ R ++ L E + LRE
Sbjct: 2570 --------QEELQQLEQQRRQQEELLAEENQRLRE 2596
Score = 30.0 bits (66), Expect = 5.8
Identities = 31/137 (22%), Positives = 56/137 (40%), Gaps = 18/137 (13%)
Query: 414 KLGTLAEGSLQLHLQDQADRVGSTASRQRQKAEMEQRRQKQLESLEQMEHPDMSLEIHYK 473
K + AE + QL Q + V R+ E E+R Q+Q E+ E + LE
Sbjct: 1581 KRASFAEKTAQLERSLQEEHVAVAQLRE----EAERRAQQQAEAERAREEAERELERWQL 1636
Query: 474 AELEKERREQRRARLAHLKSSSTRAQERERGSELSTTSPSGTSLADDDRHSQMIRDQQQQ 533
E R + +A KS + E+++ + +R ++ ++Q
Sbjct: 1637 KANEALRLRLQAEEVAQQKSLAQAEAEKQK--------------EEAEREARRRGKAEEQ 1682
Query: 534 ILQQNRLHKQFLEEARK 550
++Q L +Q LE+ R+
Sbjct: 1683 AVRQRELAEQELEKQRQ 1699
Score = 29.3 bits (64), Expect = 10.0
Identities = 21/106 (19%), Positives = 51/106 (48%), Gaps = 5/106 (4%)
Query: 398 KEDSLLYSTESGQETPKLGTLAEGSLQLHLQDQADRVGSTASRQRQKAEMEQRRQKQLES 457
+E+ L + +E +L + E +L+ Q + A +R+ E++QR Q+++
Sbjct: 1345 EEEERLAEQQRAEERERLAEV-EAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1403
Query: 458 LEQMEHPDMSLEIHYKAELEKERREQRRARLAHLKSSSTRAQERER 503
E+ K +++E ++ R++ A +++ + +A+ ER
Sbjct: 1404 REEAAVDAQ----QQKRSIQEELQQLRQSSEAEIQAKARQAEAAER 1445
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 56.2 bits (134), Expect = 8e-08
Identities = 125/587 (21%), Positives = 229/587 (39%), Gaps = 95/587 (16%)
Query: 31 LQRRADAKLWKNYQLQRLAEELRRGYQEAQH-LHVGGLDRLQSARLLGWGGGRARENEPD 89
++ A+A K LQ L EELR +EA+ L ++R + ++ R+ E E
Sbjct: 1525 VKAEAEAAREKQRALQAL-EELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQ 1583
Query: 90 SQ-GPIQRRSARPPRAKEKHRAALSEERSCREELGQQHPRHSRPRKTAASPEKPQTTKAT 148
S+ ++A+ R+ ++ A+++ R E QQ R R+ A + KA
Sbjct: 1584 SKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKAN 1643
Query: 149 GRMNSHL-------------APPEKRKGRPEPSTKSGGG--RCAIHPRRSKGADLERSNP 193
+ L A EK+K E + G A+ R +LE+
Sbjct: 1644 EALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ 1703
Query: 194 LVAAVGEIGLVEEKEKGTARAG------RRQLGKGAVCFVP--ALTSRSQGQSLEGKLRD 245
L + L E+E RA +RQL + + + A + + Q LE +L
Sbjct: 1704 LAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAK 1763
Query: 246 LG-------------------------QLWPADSSCRREAVSPASQC-TLREKNKWQKEL 279
+ Q A++ RE A++ L E+ K Q++L
Sbjct: 1764 VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQL 1823
Query: 280 ELAFEELFNINRKLKKHLCLYLALKPRMDQRPGEGHAFSEMQECGAGTPRGKKMADPEML 339
A E+ + ++ L LA + E ++E A R +++A+ E
Sbjct: 1824 --AEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEI--ALKEKEAENERLRRLAEDE-- 1877
Query: 340 PAGEPRSPAEEEAQQAASKTDLKTFMGKAQN---QKYQGTVKPTFRNGSQTLSPEAGIFI 396
A + R E+ AQ A + + KA + ++ +G V+ T R Q
Sbjct: 1878 -AFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQV--------- 1927
Query: 397 NKEDSLLYSTESGQETPKLGTLAEGSLQLHLQDQADRVGSTAS---RQRQKAEMEQRRQK 453
E+ +L S ++ A G +L L+ R+ S A R +++AE+E RQ+
Sbjct: 1928 --EEEILALKASFEKA------AAGKAELELE--LGRIRSNAEDTLRSKEQAELEAARQR 1977
Query: 454 QLESLEQMEHPDMSLEIHYKAELEKERREQRRARLAHLKSSSTRAQE----RERGS---- 505
QL + E+ + + E+E QR+A L ++ + +E RER
Sbjct: 1978 QLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESA 2037
Query: 506 ---ELSTTSPSGTSLADDDRHSQMIRDQQQQILQQNRLHKQFLEEAR 549
+L+ + A++ H+ ++ ++Q++ Q + + L++ R
Sbjct: 2038 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR 2084
Score = 35.4 bits (80), Expect = 0.14
Identities = 69/303 (22%), Positives = 118/303 (38%), Gaps = 45/303 (14%)
Query: 206 EKEKGTARAGRRQLGKGAVCFVPALTSRSQG--QSLEG-KLRDLGQLWPADSSCRREAVS 262
+++K A+ R+L + L +QG ++LE + R L A+ R A
Sbjct: 2337 QQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEM 2396
Query: 263 PASQCTLREK-NKWQKELELAFEELFNINRKLKKHLCLYLALKPRMDQRPGEGHAFSEMQ 321
+Q E +++K+ E E+L ++ + L L+ QR H ++
Sbjct: 2397 SRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI---QRQQSDHDAERLR 2453
Query: 322 ECGAGTPRGKKMADPEMLPAGEPRSPAEEEAQQAASKTDLKTFMGKAQNQKYQGTVKPTF 381
E A R K E+ QQ A LK+ ++ Q +
Sbjct: 2454 EAIAELEREK------------------EKLQQEAKLLQLKS-------EEMQTVQQEQL 2488
Query: 382 RNGSQTLSPEAGIFINKEDSLLYSTES-GQETPKLGTLAEGSLQLHLQDQADRVGSTASR 440
+Q L F++++DSLL QE KL QL + A +
Sbjct: 2489 LQETQALQQS---FLSEKDSLLQRERFIEQEKAKLE-------QLFQDEVAKAQQLREEQ 2538
Query: 441 QRQKAEMEQRRQKQLESLEQMEHPDMSLE--IHYKAELEKERREQRRARLAHLKSSSTRA 498
QRQ+ +MEQ RQ+ + S+E+ E + K E ++ +QRR + L + R
Sbjct: 2539 QRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRL 2598
Query: 499 QER 501
+E+
Sbjct: 2599 REQ 2601
Score = 34.3 bits (77), Expect = 0.31
Identities = 32/108 (29%), Positives = 50/108 (46%), Gaps = 4/108 (3%)
Query: 419 AEGSLQLHLQDQADRVGSTASRQRQKAEMEQRRQKQLESLEQMEHPDMSLEIHYKAELEK 478
AEG LQ L+ +A+ RQ Q+ RRQ Q ES ++ ++ L KAE E
Sbjct: 1475 AEGELQA-LRARAEEA-EAQKRQAQEEAERLRRQVQDES-QRKRQAEVELASRVKAEAEA 1531
Query: 479 ERREQRRAR-LAHLKSSSTRAQERERGSELSTTSPSGTSLADDDRHSQ 525
R +QR + L L+ + A+ R R +E+ +L R ++
Sbjct: 1532 AREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1579
Score = 32.3 bits (72), Expect = 1.2
Identities = 118/575 (20%), Positives = 218/575 (37%), Gaps = 74/575 (12%)
Query: 10 EDLLWRKKHKLLQARGKGDLALQRRADAKLWKNYQLQRLAEELRRGYQEAQHLHVGGLDR 69
+ L +++ L Q RG+ + A +R A+ Q +R A + RR +EA+ L ++
Sbjct: 2070 QQTLQQEQSVLDQLRGEAEAA-RRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQ 2128
Query: 70 LQSARLLGWGGGRARENEPDSQGPIQRRSARPPRAKEKHRAALSEERSCREELGQQHPRH 129
Q AR E + + R A+ +A + + A E ++ +Q R
Sbjct: 2129 AQ-ARAQAQAAAEKLRKEAEQEAA---RRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ 2184
Query: 130 SRPRKTAASPEKPQTTKATGRMNSHLAPPEKRKGRPEPSTKSGGGRCAIHPR----RSKG 185
+ + + Q + + N L E ++ + E +T++ R + R +
Sbjct: 2185 KAQVEQELTTLRLQLEETDHQKN--LLDEELQRLKAE-ATEAARQRSQVEEELFSVRVQM 2241
Query: 186 ADLERSNPLVAAVGEIGLVEEKE------KGTARAGRRQLGKGAVCFVPALTSRSQGQSL 239
+L + + A ++ +K+ + A ++ + A V A + Q
Sbjct: 2242 EELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLA 2301
Query: 240 EGKLRDLGQLWPADSSCRREAVSPASQCTLREKNKWQKELELAFEELFNINRKLKKHLCL 299
E L L + +AV A++ E Q++ ELA E+ + K+ +
Sbjct: 2302 EEDLAQQRALAEKMLKEKMQAVQEATRLKA-EAELLQQQKELAQEQARRLQED-KEQMAQ 2359
Query: 300 YLALKPRMDQRPGEGHAFSEMQECGAGTPRGKKMADPEMLPAGEPRSPAEEEAQQ---AA 356
LA + + QR E ++ E A R K+ EM A ++ AEE+AQ+ A
Sbjct: 2360 QLAEETQGFQRTLEAERQRQL-EMSAEAER-LKLRVAEMSRA---QARAEEDAQRFRKQA 2414
Query: 357 SKTDLKTFMGKAQNQKYQGTVKPTFRNGSQTLSPEAGIFINKEDSLLYSTESGQETPKLG 416
+ K + Q+ + T+ T Q +A L E Q+ KL
Sbjct: 2415 EEIGEKLHRTELATQE-KVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL 2473
Query: 417 TLAEGSLQLHLQDQA------------DRVGSTASRQR----QKAEMEQRRQKQLESLEQ 460
L +Q Q+Q S R+R +KA++EQ Q ++ +Q
Sbjct: 2474 QLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQ 2533
Query: 461 MEHPDMSLEIHYKAELEKERREQRRARL-AHLKSSSTRAQERERGSELSTTSPSGTSLAD 519
+ + + ++++ EQ R RL A ++ + R E E G
Sbjct: 2534 LRE---------EQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRK----------- 2573
Query: 520 DDRHSQMIRDQQQQILQQNRLHKQFLEEARKCLRE 554
+++ QQ+ QQ R ++ L E + LRE
Sbjct: 2574 --------QEELQQLEQQRRQQEELLAEENQRLRE 2600
Score = 30.0 bits (66), Expect = 5.8
Identities = 31/137 (22%), Positives = 56/137 (40%), Gaps = 18/137 (13%)
Query: 414 KLGTLAEGSLQLHLQDQADRVGSTASRQRQKAEMEQRRQKQLESLEQMEHPDMSLEIHYK 473
K + AE + QL Q + V R+ E E+R Q+Q E+ E + LE
Sbjct: 1585 KRASFAEKTAQLERSLQEEHVAVAQLRE----EAERRAQQQAEAERAREEAERELERWQL 1640
Query: 474 AELEKERREQRRARLAHLKSSSTRAQERERGSELSTTSPSGTSLADDDRHSQMIRDQQQQ 533
E R + +A KS + E+++ + +R ++ ++Q
Sbjct: 1641 KANEALRLRLQAEEVAQQKSLAQAEAEKQK--------------EEAEREARRRGKAEEQ 1686
Query: 534 ILQQNRLHKQFLEEARK 550
++Q L +Q LE+ R+
Sbjct: 1687 AVRQRELAEQELEKQRQ 1703
Score = 29.3 bits (64), Expect = 10.0
Identities = 21/106 (19%), Positives = 51/106 (48%), Gaps = 5/106 (4%)
Query: 398 KEDSLLYSTESGQETPKLGTLAEGSLQLHLQDQADRVGSTASRQRQKAEMEQRRQKQLES 457
+E+ L + +E +L + E +L+ Q + A +R+ E++QR Q+++
Sbjct: 1349 EEEERLAEQQRAEERERLAEV-EAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1407
Query: 458 LEQMEHPDMSLEIHYKAELEKERREQRRARLAHLKSSSTRAQERER 503
E+ K +++E ++ R++ A +++ + +A+ ER
Sbjct: 1408 REEAAVDAQ----QQKRSIQEELQQLRQSSEAEIQAKARQAEAAER 1449
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 56.2 bits (134), Expect = 8e-08
Identities = 125/587 (21%), Positives = 229/587 (39%), Gaps = 95/587 (16%)
Query: 31 LQRRADAKLWKNYQLQRLAEELRRGYQEAQH-LHVGGLDRLQSARLLGWGGGRARENEPD 89
++ A+A K LQ L EELR +EA+ L ++R + ++ R+ E E
Sbjct: 1521 VKAEAEAAREKQRALQAL-EELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQ 1579
Query: 90 SQ-GPIQRRSARPPRAKEKHRAALSEERSCREELGQQHPRHSRPRKTAASPEKPQTTKAT 148
S+ ++A+ R+ ++ A+++ R E QQ R R+ A + KA
Sbjct: 1580 SKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKAN 1639
Query: 149 GRMNSHL-------------APPEKRKGRPEPSTKSGGG--RCAIHPRRSKGADLERSNP 193
+ L A EK+K E + G A+ R +LE+
Sbjct: 1640 EALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ 1699
Query: 194 LVAAVGEIGLVEEKEKGTARAG------RRQLGKGAVCFVP--ALTSRSQGQSLEGKLRD 245
L + L E+E RA +RQL + + + A + + Q LE +L
Sbjct: 1700 LAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAK 1759
Query: 246 LG-------------------------QLWPADSSCRREAVSPASQC-TLREKNKWQKEL 279
+ Q A++ RE A++ L E+ K Q++L
Sbjct: 1760 VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQL 1819
Query: 280 ELAFEELFNINRKLKKHLCLYLALKPRMDQRPGEGHAFSEMQECGAGTPRGKKMADPEML 339
A E+ + ++ L LA + E ++E A R +++A+ E
Sbjct: 1820 --AEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEI--ALKEKEAENERLRRLAEDE-- 1873
Query: 340 PAGEPRSPAEEEAQQAASKTDLKTFMGKAQN---QKYQGTVKPTFRNGSQTLSPEAGIFI 396
A + R E+ AQ A + + KA + ++ +G V+ T R Q
Sbjct: 1874 -AFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQV--------- 1923
Query: 397 NKEDSLLYSTESGQETPKLGTLAEGSLQLHLQDQADRVGSTAS---RQRQKAEMEQRRQK 453
E+ +L S ++ A G +L L+ R+ S A R +++AE+E RQ+
Sbjct: 1924 --EEEILALKASFEKA------AAGKAELELE--LGRIRSNAEDTLRSKEQAELEAARQR 1973
Query: 454 QLESLEQMEHPDMSLEIHYKAELEKERREQRRARLAHLKSSSTRAQE----RERGS---- 505
QL + E+ + + E+E QR+A L ++ + +E RER
Sbjct: 1974 QLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESA 2033
Query: 506 ---ELSTTSPSGTSLADDDRHSQMIRDQQQQILQQNRLHKQFLEEAR 549
+L+ + A++ H+ ++ ++Q++ Q + + L++ R
Sbjct: 2034 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR 2080
Score = 35.4 bits (80), Expect = 0.14
Identities = 69/303 (22%), Positives = 118/303 (38%), Gaps = 45/303 (14%)
Query: 206 EKEKGTARAGRRQLGKGAVCFVPALTSRSQG--QSLEG-KLRDLGQLWPADSSCRREAVS 262
+++K A+ R+L + L +QG ++LE + R L A+ R A
Sbjct: 2333 QQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEM 2392
Query: 263 PASQCTLREK-NKWQKELELAFEELFNINRKLKKHLCLYLALKPRMDQRPGEGHAFSEMQ 321
+Q E +++K+ E E+L ++ + L L+ QR H ++
Sbjct: 2393 SRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI---QRQQSDHDAERLR 2449
Query: 322 ECGAGTPRGKKMADPEMLPAGEPRSPAEEEAQQAASKTDLKTFMGKAQNQKYQGTVKPTF 381
E A R K E+ QQ A LK+ ++ Q +
Sbjct: 2450 EAIAELEREK------------------EKLQQEAKLLQLKS-------EEMQTVQQEQL 2484
Query: 382 RNGSQTLSPEAGIFINKEDSLLYSTES-GQETPKLGTLAEGSLQLHLQDQADRVGSTASR 440
+Q L F++++DSLL QE KL QL + A +
Sbjct: 2485 LQETQALQQS---FLSEKDSLLQRERFIEQEKAKLE-------QLFQDEVAKAQQLREEQ 2534
Query: 441 QRQKAEMEQRRQKQLESLEQMEHPDMSLE--IHYKAELEKERREQRRARLAHLKSSSTRA 498
QRQ+ +MEQ RQ+ + S+E+ E + K E ++ +QRR + L + R
Sbjct: 2535 QRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRL 2594
Query: 499 QER 501
+E+
Sbjct: 2595 REQ 2597
Score = 34.3 bits (77), Expect = 0.31
Identities = 32/108 (29%), Positives = 50/108 (46%), Gaps = 4/108 (3%)
Query: 419 AEGSLQLHLQDQADRVGSTASRQRQKAEMEQRRQKQLESLEQMEHPDMSLEIHYKAELEK 478
AEG LQ L+ +A+ RQ Q+ RRQ Q ES ++ ++ L KAE E
Sbjct: 1471 AEGELQA-LRARAEEA-EAQKRQAQEEAERLRRQVQDES-QRKRQAEVELASRVKAEAEA 1527
Query: 479 ERREQRRAR-LAHLKSSSTRAQERERGSELSTTSPSGTSLADDDRHSQ 525
R +QR + L L+ + A+ R R +E+ +L R ++
Sbjct: 1528 AREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1575
Score = 32.3 bits (72), Expect = 1.2
Identities = 118/575 (20%), Positives = 218/575 (37%), Gaps = 74/575 (12%)
Query: 10 EDLLWRKKHKLLQARGKGDLALQRRADAKLWKNYQLQRLAEELRRGYQEAQHLHVGGLDR 69
+ L +++ L Q RG+ + A +R A+ Q +R A + RR +EA+ L ++
Sbjct: 2066 QQTLQQEQSVLDQLRGEAEAA-RRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQ 2124
Query: 70 LQSARLLGWGGGRARENEPDSQGPIQRRSARPPRAKEKHRAALSEERSCREELGQQHPRH 129
Q AR E + + R A+ +A + + A E ++ +Q R
Sbjct: 2125 AQ-ARAQAQAAAEKLRKEAEQEAA---RRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ 2180
Query: 130 SRPRKTAASPEKPQTTKATGRMNSHLAPPEKRKGRPEPSTKSGGGRCAIHPR----RSKG 185
+ + + Q + + N L E ++ + E +T++ R + R +
Sbjct: 2181 KAQVEQELTTLRLQLEETDHQKN--LLDEELQRLKAE-ATEAARQRSQVEEELFSVRVQM 2237
Query: 186 ADLERSNPLVAAVGEIGLVEEKE------KGTARAGRRQLGKGAVCFVPALTSRSQGQSL 239
+L + + A ++ +K+ + A ++ + A V A + Q
Sbjct: 2238 EELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLA 2297
Query: 240 EGKLRDLGQLWPADSSCRREAVSPASQCTLREKNKWQKELELAFEELFNINRKLKKHLCL 299
E L L + +AV A++ E Q++ ELA E+ + K+ +
Sbjct: 2298 EEDLAQQRALAEKMLKEKMQAVQEATRLKA-EAELLQQQKELAQEQARRLQED-KEQMAQ 2355
Query: 300 YLALKPRMDQRPGEGHAFSEMQECGAGTPRGKKMADPEMLPAGEPRSPAEEEAQQ---AA 356
LA + + QR E ++ E A R K+ EM A ++ AEE+AQ+ A
Sbjct: 2356 QLAEETQGFQRTLEAERQRQL-EMSAEAER-LKLRVAEMSRA---QARAEEDAQRFRKQA 2410
Query: 357 SKTDLKTFMGKAQNQKYQGTVKPTFRNGSQTLSPEAGIFINKEDSLLYSTESGQETPKLG 416
+ K + Q+ + T+ T Q +A L E Q+ KL
Sbjct: 2411 EEIGEKLHRTELATQE-KVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL 2469
Query: 417 TLAEGSLQLHLQDQA------------DRVGSTASRQR----QKAEMEQRRQKQLESLEQ 460
L +Q Q+Q S R+R +KA++EQ Q ++ +Q
Sbjct: 2470 QLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQ 2529
Query: 461 MEHPDMSLEIHYKAELEKERREQRRARL-AHLKSSSTRAQERERGSELSTTSPSGTSLAD 519
+ + + ++++ EQ R RL A ++ + R E E G
Sbjct: 2530 LRE---------EQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRK----------- 2569
Query: 520 DDRHSQMIRDQQQQILQQNRLHKQFLEEARKCLRE 554
+++ QQ+ QQ R ++ L E + LRE
Sbjct: 2570 --------QEELQQLEQQRRQQEELLAEENQRLRE 2596
Score = 30.0 bits (66), Expect = 5.8
Identities = 31/137 (22%), Positives = 56/137 (40%), Gaps = 18/137 (13%)
Query: 414 KLGTLAEGSLQLHLQDQADRVGSTASRQRQKAEMEQRRQKQLESLEQMEHPDMSLEIHYK 473
K + AE + QL Q + V R+ E E+R Q+Q E+ E + LE
Sbjct: 1581 KRASFAEKTAQLERSLQEEHVAVAQLRE----EAERRAQQQAEAERAREEAERELERWQL 1636
Query: 474 AELEKERREQRRARLAHLKSSSTRAQERERGSELSTTSPSGTSLADDDRHSQMIRDQQQQ 533
E R + +A KS + E+++ + +R ++ ++Q
Sbjct: 1637 KANEALRLRLQAEEVAQQKSLAQAEAEKQK--------------EEAEREARRRGKAEEQ 1682
Query: 534 ILQQNRLHKQFLEEARK 550
++Q L +Q LE+ R+
Sbjct: 1683 AVRQRELAEQELEKQRQ 1699
Score = 29.3 bits (64), Expect = 10.0
Identities = 21/106 (19%), Positives = 51/106 (48%), Gaps = 5/106 (4%)
Query: 398 KEDSLLYSTESGQETPKLGTLAEGSLQLHLQDQADRVGSTASRQRQKAEMEQRRQKQLES 457
+E+ L + +E +L + E +L+ Q + A +R+ E++QR Q+++
Sbjct: 1345 EEEERLAEQQRAEERERLAEV-EAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1403
Query: 458 LEQMEHPDMSLEIHYKAELEKERREQRRARLAHLKSSSTRAQERER 503
E+ K +++E ++ R++ A +++ + +A+ ER
Sbjct: 1404 REEAAVDAQ----QQKRSIQEELQQLRQSSEAEIQAKARQAEAAER 1445
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 56.2 bits (134), Expect = 8e-08
Identities = 125/587 (21%), Positives = 229/587 (39%), Gaps = 95/587 (16%)
Query: 31 LQRRADAKLWKNYQLQRLAEELRRGYQEAQH-LHVGGLDRLQSARLLGWGGGRARENEPD 89
++ A+A K LQ L EELR +EA+ L ++R + ++ R+ E E
Sbjct: 1489 VKAEAEAAREKQRALQAL-EELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQ 1547
Query: 90 SQ-GPIQRRSARPPRAKEKHRAALSEERSCREELGQQHPRHSRPRKTAASPEKPQTTKAT 148
S+ ++A+ R+ ++ A+++ R E QQ R R+ A + KA
Sbjct: 1548 SKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKAN 1607
Query: 149 GRMNSHL-------------APPEKRKGRPEPSTKSGGG--RCAIHPRRSKGADLERSNP 193
+ L A EK+K E + G A+ R +LE+
Sbjct: 1608 EALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ 1667
Query: 194 LVAAVGEIGLVEEKEKGTARAG------RRQLGKGAVCFVP--ALTSRSQGQSLEGKLRD 245
L + L E+E RA +RQL + + + A + + Q LE +L
Sbjct: 1668 LAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAK 1727
Query: 246 LG-------------------------QLWPADSSCRREAVSPASQC-TLREKNKWQKEL 279
+ Q A++ RE A++ L E+ K Q++L
Sbjct: 1728 VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQL 1787
Query: 280 ELAFEELFNINRKLKKHLCLYLALKPRMDQRPGEGHAFSEMQECGAGTPRGKKMADPEML 339
A E+ + ++ L LA + E ++E A R +++A+ E
Sbjct: 1788 --AEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEI--ALKEKEAENERLRRLAEDE-- 1841
Query: 340 PAGEPRSPAEEEAQQAASKTDLKTFMGKAQN---QKYQGTVKPTFRNGSQTLSPEAGIFI 396
A + R E+ AQ A + + KA + ++ +G V+ T R Q
Sbjct: 1842 -AFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQV--------- 1891
Query: 397 NKEDSLLYSTESGQETPKLGTLAEGSLQLHLQDQADRVGSTAS---RQRQKAEMEQRRQK 453
E+ +L S ++ A G +L L+ R+ S A R +++AE+E RQ+
Sbjct: 1892 --EEEILALKASFEKA------AAGKAELELE--LGRIRSNAEDTLRSKEQAELEAARQR 1941
Query: 454 QLESLEQMEHPDMSLEIHYKAELEKERREQRRARLAHLKSSSTRAQE----RERGS---- 505
QL + E+ + + E+E QR+A L ++ + +E RER
Sbjct: 1942 QLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESA 2001
Query: 506 ---ELSTTSPSGTSLADDDRHSQMIRDQQQQILQQNRLHKQFLEEAR 549
+L+ + A++ H+ ++ ++Q++ Q + + L++ R
Sbjct: 2002 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR 2048
Score = 35.4 bits (80), Expect = 0.14
Identities = 69/303 (22%), Positives = 118/303 (38%), Gaps = 45/303 (14%)
Query: 206 EKEKGTARAGRRQLGKGAVCFVPALTSRSQG--QSLEG-KLRDLGQLWPADSSCRREAVS 262
+++K A+ R+L + L +QG ++LE + R L A+ R A
Sbjct: 2301 QQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEM 2360
Query: 263 PASQCTLREK-NKWQKELELAFEELFNINRKLKKHLCLYLALKPRMDQRPGEGHAFSEMQ 321
+Q E +++K+ E E+L ++ + L L+ QR H ++
Sbjct: 2361 SRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI---QRQQSDHDAERLR 2417
Query: 322 ECGAGTPRGKKMADPEMLPAGEPRSPAEEEAQQAASKTDLKTFMGKAQNQKYQGTVKPTF 381
E A R K E+ QQ A LK+ ++ Q +
Sbjct: 2418 EAIAELEREK------------------EKLQQEAKLLQLKS-------EEMQTVQQEQL 2452
Query: 382 RNGSQTLSPEAGIFINKEDSLLYSTES-GQETPKLGTLAEGSLQLHLQDQADRVGSTASR 440
+Q L F++++DSLL QE KL QL + A +
Sbjct: 2453 LQETQALQQS---FLSEKDSLLQRERFIEQEKAKLE-------QLFQDEVAKAQQLREEQ 2502
Query: 441 QRQKAEMEQRRQKQLESLEQMEHPDMSLE--IHYKAELEKERREQRRARLAHLKSSSTRA 498
QRQ+ +MEQ RQ+ + S+E+ E + K E ++ +QRR + L + R
Sbjct: 2503 QRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRL 2562
Query: 499 QER 501
+E+
Sbjct: 2563 REQ 2565
Score = 34.3 bits (77), Expect = 0.31
Identities = 32/108 (29%), Positives = 50/108 (46%), Gaps = 4/108 (3%)
Query: 419 AEGSLQLHLQDQADRVGSTASRQRQKAEMEQRRQKQLESLEQMEHPDMSLEIHYKAELEK 478
AEG LQ L+ +A+ RQ Q+ RRQ Q ES ++ ++ L KAE E
Sbjct: 1439 AEGELQA-LRARAEEA-EAQKRQAQEEAERLRRQVQDES-QRKRQAEVELASRVKAEAEA 1495
Query: 479 ERREQRRAR-LAHLKSSSTRAQERERGSELSTTSPSGTSLADDDRHSQ 525
R +QR + L L+ + A+ R R +E+ +L R ++
Sbjct: 1496 AREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1543
Score = 32.3 bits (72), Expect = 1.2
Identities = 118/575 (20%), Positives = 218/575 (37%), Gaps = 74/575 (12%)
Query: 10 EDLLWRKKHKLLQARGKGDLALQRRADAKLWKNYQLQRLAEELRRGYQEAQHLHVGGLDR 69
+ L +++ L Q RG+ + A +R A+ Q +R A + RR +EA+ L ++
Sbjct: 2034 QQTLQQEQSVLDQLRGEAEAA-RRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQ 2092
Query: 70 LQSARLLGWGGGRARENEPDSQGPIQRRSARPPRAKEKHRAALSEERSCREELGQQHPRH 129
Q AR E + + R A+ +A + + A E ++ +Q R
Sbjct: 2093 AQ-ARAQAQAAAEKLRKEAEQEAA---RRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ 2148
Query: 130 SRPRKTAASPEKPQTTKATGRMNSHLAPPEKRKGRPEPSTKSGGGRCAIHPR----RSKG 185
+ + + Q + + N L E ++ + E +T++ R + R +
Sbjct: 2149 KAQVEQELTTLRLQLEETDHQKN--LLDEELQRLKAE-ATEAARQRSQVEEELFSVRVQM 2205
Query: 186 ADLERSNPLVAAVGEIGLVEEKE------KGTARAGRRQLGKGAVCFVPALTSRSQGQSL 239
+L + + A ++ +K+ + A ++ + A V A + Q
Sbjct: 2206 EELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLA 2265
Query: 240 EGKLRDLGQLWPADSSCRREAVSPASQCTLREKNKWQKELELAFEELFNINRKLKKHLCL 299
E L L + +AV A++ E Q++ ELA E+ + K+ +
Sbjct: 2266 EEDLAQQRALAEKMLKEKMQAVQEATRLKA-EAELLQQQKELAQEQARRLQED-KEQMAQ 2323
Query: 300 YLALKPRMDQRPGEGHAFSEMQECGAGTPRGKKMADPEMLPAGEPRSPAEEEAQQ---AA 356
LA + + QR E ++ E A R K+ EM A ++ AEE+AQ+ A
Sbjct: 2324 QLAEETQGFQRTLEAERQRQL-EMSAEAER-LKLRVAEMSRA---QARAEEDAQRFRKQA 2378
Query: 357 SKTDLKTFMGKAQNQKYQGTVKPTFRNGSQTLSPEAGIFINKEDSLLYSTESGQETPKLG 416
+ K + Q+ + T+ T Q +A L E Q+ KL
Sbjct: 2379 EEIGEKLHRTELATQE-KVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL 2437
Query: 417 TLAEGSLQLHLQDQA------------DRVGSTASRQR----QKAEMEQRRQKQLESLEQ 460
L +Q Q+Q S R+R +KA++EQ Q ++ +Q
Sbjct: 2438 QLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQ 2497
Query: 461 MEHPDMSLEIHYKAELEKERREQRRARL-AHLKSSSTRAQERERGSELSTTSPSGTSLAD 519
+ + + ++++ EQ R RL A ++ + R E E G
Sbjct: 2498 LRE---------EQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRK----------- 2537
Query: 520 DDRHSQMIRDQQQQILQQNRLHKQFLEEARKCLRE 554
+++ QQ+ QQ R ++ L E + LRE
Sbjct: 2538 --------QEELQQLEQQRRQQEELLAEENQRLRE 2564
Score = 30.0 bits (66), Expect = 5.8
Identities = 31/137 (22%), Positives = 56/137 (40%), Gaps = 18/137 (13%)
Query: 414 KLGTLAEGSLQLHLQDQADRVGSTASRQRQKAEMEQRRQKQLESLEQMEHPDMSLEIHYK 473
K + AE + QL Q + V R+ E E+R Q+Q E+ E + LE
Sbjct: 1549 KRASFAEKTAQLERSLQEEHVAVAQLRE----EAERRAQQQAEAERAREEAERELERWQL 1604
Query: 474 AELEKERREQRRARLAHLKSSSTRAQERERGSELSTTSPSGTSLADDDRHSQMIRDQQQQ 533
E R + +A KS + E+++ + +R ++ ++Q
Sbjct: 1605 KANEALRLRLQAEEVAQQKSLAQAEAEKQK--------------EEAEREARRRGKAEEQ 1650
Query: 534 ILQQNRLHKQFLEEARK 550
++Q L +Q LE+ R+
Sbjct: 1651 AVRQRELAEQELEKQRQ 1667
Score = 29.3 bits (64), Expect = 10.0
Identities = 21/106 (19%), Positives = 51/106 (48%), Gaps = 5/106 (4%)
Query: 398 KEDSLLYSTESGQETPKLGTLAEGSLQLHLQDQADRVGSTASRQRQKAEMEQRRQKQLES 457
+E+ L + +E +L + E +L+ Q + A +R+ E++QR Q+++
Sbjct: 1313 EEEERLAEQQRAEERERLAEV-EAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1371
Query: 458 LEQMEHPDMSLEIHYKAELEKERREQRRARLAHLKSSSTRAQERER 503
E+ K +++E ++ R++ A +++ + +A+ ER
Sbjct: 1372 REEAAVDAQ----QQKRSIQEELQQLRQSSEAEIQAKARQAEAAER 1413
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 56.2 bits (134), Expect = 8e-08
Identities = 125/587 (21%), Positives = 229/587 (39%), Gaps = 95/587 (16%)
Query: 31 LQRRADAKLWKNYQLQRLAEELRRGYQEAQH-LHVGGLDRLQSARLLGWGGGRARENEPD 89
++ A+A K LQ L EELR +EA+ L ++R + ++ R+ E E
Sbjct: 1658 VKAEAEAAREKQRALQAL-EELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQ 1716
Query: 90 SQ-GPIQRRSARPPRAKEKHRAALSEERSCREELGQQHPRHSRPRKTAASPEKPQTTKAT 148
S+ ++A+ R+ ++ A+++ R E QQ R R+ A + KA
Sbjct: 1717 SKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKAN 1776
Query: 149 GRMNSHL-------------APPEKRKGRPEPSTKSGGG--RCAIHPRRSKGADLERSNP 193
+ L A EK+K E + G A+ R +LE+
Sbjct: 1777 EALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ 1836
Query: 194 LVAAVGEIGLVEEKEKGTARAG------RRQLGKGAVCFVP--ALTSRSQGQSLEGKLRD 245
L + L E+E RA +RQL + + + A + + Q LE +L
Sbjct: 1837 LAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAK 1896
Query: 246 LG-------------------------QLWPADSSCRREAVSPASQC-TLREKNKWQKEL 279
+ Q A++ RE A++ L E+ K Q++L
Sbjct: 1897 VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQL 1956
Query: 280 ELAFEELFNINRKLKKHLCLYLALKPRMDQRPGEGHAFSEMQECGAGTPRGKKMADPEML 339
A E+ + ++ L LA + E ++E A R +++A+ E
Sbjct: 1957 --AEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEI--ALKEKEAENERLRRLAEDE-- 2010
Query: 340 PAGEPRSPAEEEAQQAASKTDLKTFMGKAQN---QKYQGTVKPTFRNGSQTLSPEAGIFI 396
A + R E+ AQ A + + KA + ++ +G V+ T R Q
Sbjct: 2011 -AFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQV--------- 2060
Query: 397 NKEDSLLYSTESGQETPKLGTLAEGSLQLHLQDQADRVGSTAS---RQRQKAEMEQRRQK 453
E+ +L S ++ A G +L L+ R+ S A R +++AE+E RQ+
Sbjct: 2061 --EEEILALKASFEKA------AAGKAELELE--LGRIRSNAEDTLRSKEQAELEAARQR 2110
Query: 454 QLESLEQMEHPDMSLEIHYKAELEKERREQRRARLAHLKSSSTRAQE----RERGS---- 505
QL + E+ + + E+E QR+A L ++ + +E RER
Sbjct: 2111 QLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESA 2170
Query: 506 ---ELSTTSPSGTSLADDDRHSQMIRDQQQQILQQNRLHKQFLEEAR 549
+L+ + A++ H+ ++ ++Q++ Q + + L++ R
Sbjct: 2171 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR 2217
Score = 35.4 bits (80), Expect = 0.14
Identities = 69/303 (22%), Positives = 118/303 (38%), Gaps = 45/303 (14%)
Query: 206 EKEKGTARAGRRQLGKGAVCFVPALTSRSQG--QSLEG-KLRDLGQLWPADSSCRREAVS 262
+++K A+ R+L + L +QG ++LE + R L A+ R A
Sbjct: 2470 QQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEM 2529
Query: 263 PASQCTLREK-NKWQKELELAFEELFNINRKLKKHLCLYLALKPRMDQRPGEGHAFSEMQ 321
+Q E +++K+ E E+L ++ + L L+ QR H ++
Sbjct: 2530 SRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI---QRQQSDHDAERLR 2586
Query: 322 ECGAGTPRGKKMADPEMLPAGEPRSPAEEEAQQAASKTDLKTFMGKAQNQKYQGTVKPTF 381
E A R K E+ QQ A LK+ ++ Q +
Sbjct: 2587 EAIAELEREK------------------EKLQQEAKLLQLKS-------EEMQTVQQEQL 2621
Query: 382 RNGSQTLSPEAGIFINKEDSLLYSTES-GQETPKLGTLAEGSLQLHLQDQADRVGSTASR 440
+Q L F++++DSLL QE KL QL + A +
Sbjct: 2622 LQETQALQQS---FLSEKDSLLQRERFIEQEKAKLE-------QLFQDEVAKAQQLREEQ 2671
Query: 441 QRQKAEMEQRRQKQLESLEQMEHPDMSLE--IHYKAELEKERREQRRARLAHLKSSSTRA 498
QRQ+ +MEQ RQ+ + S+E+ E + K E ++ +QRR + L + R
Sbjct: 2672 QRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRL 2731
Query: 499 QER 501
+E+
Sbjct: 2732 REQ 2734
Score = 34.3 bits (77), Expect = 0.31
Identities = 32/108 (29%), Positives = 50/108 (46%), Gaps = 4/108 (3%)
Query: 419 AEGSLQLHLQDQADRVGSTASRQRQKAEMEQRRQKQLESLEQMEHPDMSLEIHYKAELEK 478
AEG LQ L+ +A+ RQ Q+ RRQ Q ES ++ ++ L KAE E
Sbjct: 1608 AEGELQA-LRARAEEA-EAQKRQAQEEAERLRRQVQDES-QRKRQAEVELASRVKAEAEA 1664
Query: 479 ERREQRRAR-LAHLKSSSTRAQERERGSELSTTSPSGTSLADDDRHSQ 525
R +QR + L L+ + A+ R R +E+ +L R ++
Sbjct: 1665 AREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1712
Score = 32.3 bits (72), Expect = 1.2
Identities = 118/575 (20%), Positives = 218/575 (37%), Gaps = 74/575 (12%)
Query: 10 EDLLWRKKHKLLQARGKGDLALQRRADAKLWKNYQLQRLAEELRRGYQEAQHLHVGGLDR 69
+ L +++ L Q RG+ + A +R A+ Q +R A + RR +EA+ L ++
Sbjct: 2203 QQTLQQEQSVLDQLRGEAEAA-RRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQ 2261
Query: 70 LQSARLLGWGGGRARENEPDSQGPIQRRSARPPRAKEKHRAALSEERSCREELGQQHPRH 129
Q AR E + + R A+ +A + + A E ++ +Q R
Sbjct: 2262 AQ-ARAQAQAAAEKLRKEAEQEAA---RRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ 2317
Query: 130 SRPRKTAASPEKPQTTKATGRMNSHLAPPEKRKGRPEPSTKSGGGRCAIHPR----RSKG 185
+ + + Q + + N L E ++ + E +T++ R + R +
Sbjct: 2318 KAQVEQELTTLRLQLEETDHQKN--LLDEELQRLKAE-ATEAARQRSQVEEELFSVRVQM 2374
Query: 186 ADLERSNPLVAAVGEIGLVEEKE------KGTARAGRRQLGKGAVCFVPALTSRSQGQSL 239
+L + + A ++ +K+ + A ++ + A V A + Q
Sbjct: 2375 EELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLA 2434
Query: 240 EGKLRDLGQLWPADSSCRREAVSPASQCTLREKNKWQKELELAFEELFNINRKLKKHLCL 299
E L L + +AV A++ E Q++ ELA E+ + K+ +
Sbjct: 2435 EEDLAQQRALAEKMLKEKMQAVQEATRLKA-EAELLQQQKELAQEQARRLQED-KEQMAQ 2492
Query: 300 YLALKPRMDQRPGEGHAFSEMQECGAGTPRGKKMADPEMLPAGEPRSPAEEEAQQ---AA 356
LA + + QR E ++ E A R K+ EM A ++ AEE+AQ+ A
Sbjct: 2493 QLAEETQGFQRTLEAERQRQL-EMSAEAER-LKLRVAEMSRA---QARAEEDAQRFRKQA 2547
Query: 357 SKTDLKTFMGKAQNQKYQGTVKPTFRNGSQTLSPEAGIFINKEDSLLYSTESGQETPKLG 416
+ K + Q+ + T+ T Q +A L E Q+ KL
Sbjct: 2548 EEIGEKLHRTELATQE-KVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL 2606
Query: 417 TLAEGSLQLHLQDQA------------DRVGSTASRQR----QKAEMEQRRQKQLESLEQ 460
L +Q Q+Q S R+R +KA++EQ Q ++ +Q
Sbjct: 2607 QLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQ 2666
Query: 461 MEHPDMSLEIHYKAELEKERREQRRARL-AHLKSSSTRAQERERGSELSTTSPSGTSLAD 519
+ + + ++++ EQ R RL A ++ + R E E G
Sbjct: 2667 LRE---------EQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRK----------- 2706
Query: 520 DDRHSQMIRDQQQQILQQNRLHKQFLEEARKCLRE 554
+++ QQ+ QQ R ++ L E + LRE
Sbjct: 2707 --------QEELQQLEQQRRQQEELLAEENQRLRE 2733
Score = 30.0 bits (66), Expect = 5.8
Identities = 31/137 (22%), Positives = 56/137 (40%), Gaps = 18/137 (13%)
Query: 414 KLGTLAEGSLQLHLQDQADRVGSTASRQRQKAEMEQRRQKQLESLEQMEHPDMSLEIHYK 473
K + AE + QL Q + V R+ E E+R Q+Q E+ E + LE
Sbjct: 1718 KRASFAEKTAQLERSLQEEHVAVAQLRE----EAERRAQQQAEAERAREEAERELERWQL 1773
Query: 474 AELEKERREQRRARLAHLKSSSTRAQERERGSELSTTSPSGTSLADDDRHSQMIRDQQQQ 533
E R + +A KS + E+++ + +R ++ ++Q
Sbjct: 1774 KANEALRLRLQAEEVAQQKSLAQAEAEKQK--------------EEAEREARRRGKAEEQ 1819
Query: 534 ILQQNRLHKQFLEEARK 550
++Q L +Q LE+ R+
Sbjct: 1820 AVRQRELAEQELEKQRQ 1836
Score = 29.3 bits (64), Expect = 10.0
Identities = 21/106 (19%), Positives = 51/106 (48%), Gaps = 5/106 (4%)
Query: 398 KEDSLLYSTESGQETPKLGTLAEGSLQLHLQDQADRVGSTASRQRQKAEMEQRRQKQLES 457
+E+ L + +E +L + E +L+ Q + A +R+ E++QR Q+++
Sbjct: 1482 EEEERLAEQQRAEERERLAEV-EAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1540
Query: 458 LEQMEHPDMSLEIHYKAELEKERREQRRARLAHLKSSSTRAQERER 503
E+ K +++E ++ R++ A +++ + +A+ ER
Sbjct: 1541 REEAAVDAQ----QQKRSIQEELQQLRQSSEAEIQAKARQAEAAER 1582
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 56.2 bits (134), Expect = 8e-08
Identities = 125/587 (21%), Positives = 229/587 (39%), Gaps = 95/587 (16%)
Query: 31 LQRRADAKLWKNYQLQRLAEELRRGYQEAQH-LHVGGLDRLQSARLLGWGGGRARENEPD 89
++ A+A K LQ L EELR +EA+ L ++R + ++ R+ E E
Sbjct: 1499 VKAEAEAAREKQRALQAL-EELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQ 1557
Query: 90 SQ-GPIQRRSARPPRAKEKHRAALSEERSCREELGQQHPRHSRPRKTAASPEKPQTTKAT 148
S+ ++A+ R+ ++ A+++ R E QQ R R+ A + KA
Sbjct: 1558 SKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKAN 1617
Query: 149 GRMNSHL-------------APPEKRKGRPEPSTKSGGG--RCAIHPRRSKGADLERSNP 193
+ L A EK+K E + G A+ R +LE+
Sbjct: 1618 EALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ 1677
Query: 194 LVAAVGEIGLVEEKEKGTARAG------RRQLGKGAVCFVP--ALTSRSQGQSLEGKLRD 245
L + L E+E RA +RQL + + + A + + Q LE +L
Sbjct: 1678 LAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAK 1737
Query: 246 LG-------------------------QLWPADSSCRREAVSPASQC-TLREKNKWQKEL 279
+ Q A++ RE A++ L E+ K Q++L
Sbjct: 1738 VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQL 1797
Query: 280 ELAFEELFNINRKLKKHLCLYLALKPRMDQRPGEGHAFSEMQECGAGTPRGKKMADPEML 339
A E+ + ++ L LA + E ++E A R +++A+ E
Sbjct: 1798 --AEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEI--ALKEKEAENERLRRLAEDE-- 1851
Query: 340 PAGEPRSPAEEEAQQAASKTDLKTFMGKAQN---QKYQGTVKPTFRNGSQTLSPEAGIFI 396
A + R E+ AQ A + + KA + ++ +G V+ T R Q
Sbjct: 1852 -AFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQV--------- 1901
Query: 397 NKEDSLLYSTESGQETPKLGTLAEGSLQLHLQDQADRVGSTAS---RQRQKAEMEQRRQK 453
E+ +L S ++ A G +L L+ R+ S A R +++AE+E RQ+
Sbjct: 1902 --EEEILALKASFEKA------AAGKAELELE--LGRIRSNAEDTLRSKEQAELEAARQR 1951
Query: 454 QLESLEQMEHPDMSLEIHYKAELEKERREQRRARLAHLKSSSTRAQE----RERGS---- 505
QL + E+ + + E+E QR+A L ++ + +E RER
Sbjct: 1952 QLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESA 2011
Query: 506 ---ELSTTSPSGTSLADDDRHSQMIRDQQQQILQQNRLHKQFLEEAR 549
+L+ + A++ H+ ++ ++Q++ Q + + L++ R
Sbjct: 2012 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR 2058
Score = 35.4 bits (80), Expect = 0.14
Identities = 69/303 (22%), Positives = 118/303 (38%), Gaps = 45/303 (14%)
Query: 206 EKEKGTARAGRRQLGKGAVCFVPALTSRSQG--QSLEG-KLRDLGQLWPADSSCRREAVS 262
+++K A+ R+L + L +QG ++LE + R L A+ R A
Sbjct: 2311 QQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEM 2370
Query: 263 PASQCTLREK-NKWQKELELAFEELFNINRKLKKHLCLYLALKPRMDQRPGEGHAFSEMQ 321
+Q E +++K+ E E+L ++ + L L+ QR H ++
Sbjct: 2371 SRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI---QRQQSDHDAERLR 2427
Query: 322 ECGAGTPRGKKMADPEMLPAGEPRSPAEEEAQQAASKTDLKTFMGKAQNQKYQGTVKPTF 381
E A R K E+ QQ A LK+ ++ Q +
Sbjct: 2428 EAIAELEREK------------------EKLQQEAKLLQLKS-------EEMQTVQQEQL 2462
Query: 382 RNGSQTLSPEAGIFINKEDSLLYSTES-GQETPKLGTLAEGSLQLHLQDQADRVGSTASR 440
+Q L F++++DSLL QE KL QL + A +
Sbjct: 2463 LQETQALQQS---FLSEKDSLLQRERFIEQEKAKLE-------QLFQDEVAKAQQLREEQ 2512
Query: 441 QRQKAEMEQRRQKQLESLEQMEHPDMSLE--IHYKAELEKERREQRRARLAHLKSSSTRA 498
QRQ+ +MEQ RQ+ + S+E+ E + K E ++ +QRR + L + R
Sbjct: 2513 QRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRL 2572
Query: 499 QER 501
+E+
Sbjct: 2573 REQ 2575
Score = 34.3 bits (77), Expect = 0.31
Identities = 32/108 (29%), Positives = 50/108 (46%), Gaps = 4/108 (3%)
Query: 419 AEGSLQLHLQDQADRVGSTASRQRQKAEMEQRRQKQLESLEQMEHPDMSLEIHYKAELEK 478
AEG LQ L+ +A+ RQ Q+ RRQ Q ES ++ ++ L KAE E
Sbjct: 1449 AEGELQA-LRARAEEA-EAQKRQAQEEAERLRRQVQDES-QRKRQAEVELASRVKAEAEA 1505
Query: 479 ERREQRRAR-LAHLKSSSTRAQERERGSELSTTSPSGTSLADDDRHSQ 525
R +QR + L L+ + A+ R R +E+ +L R ++
Sbjct: 1506 AREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1553
Score = 32.3 bits (72), Expect = 1.2
Identities = 118/575 (20%), Positives = 218/575 (37%), Gaps = 74/575 (12%)
Query: 10 EDLLWRKKHKLLQARGKGDLALQRRADAKLWKNYQLQRLAEELRRGYQEAQHLHVGGLDR 69
+ L +++ L Q RG+ + A +R A+ Q +R A + RR +EA+ L ++
Sbjct: 2044 QQTLQQEQSVLDQLRGEAEAA-RRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQ 2102
Query: 70 LQSARLLGWGGGRARENEPDSQGPIQRRSARPPRAKEKHRAALSEERSCREELGQQHPRH 129
Q AR E + + R A+ +A + + A E ++ +Q R
Sbjct: 2103 AQ-ARAQAQAAAEKLRKEAEQEAA---RRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ 2158
Query: 130 SRPRKTAASPEKPQTTKATGRMNSHLAPPEKRKGRPEPSTKSGGGRCAIHPR----RSKG 185
+ + + Q + + N L E ++ + E +T++ R + R +
Sbjct: 2159 KAQVEQELTTLRLQLEETDHQKN--LLDEELQRLKAE-ATEAARQRSQVEEELFSVRVQM 2215
Query: 186 ADLERSNPLVAAVGEIGLVEEKE------KGTARAGRRQLGKGAVCFVPALTSRSQGQSL 239
+L + + A ++ +K+ + A ++ + A V A + Q
Sbjct: 2216 EELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLA 2275
Query: 240 EGKLRDLGQLWPADSSCRREAVSPASQCTLREKNKWQKELELAFEELFNINRKLKKHLCL 299
E L L + +AV A++ E Q++ ELA E+ + K+ +
Sbjct: 2276 EEDLAQQRALAEKMLKEKMQAVQEATRLKA-EAELLQQQKELAQEQARRLQED-KEQMAQ 2333
Query: 300 YLALKPRMDQRPGEGHAFSEMQECGAGTPRGKKMADPEMLPAGEPRSPAEEEAQQ---AA 356
LA + + QR E ++ E A R K+ EM A ++ AEE+AQ+ A
Sbjct: 2334 QLAEETQGFQRTLEAERQRQL-EMSAEAER-LKLRVAEMSRA---QARAEEDAQRFRKQA 2388
Query: 357 SKTDLKTFMGKAQNQKYQGTVKPTFRNGSQTLSPEAGIFINKEDSLLYSTESGQETPKLG 416
+ K + Q+ + T+ T Q +A L E Q+ KL
Sbjct: 2389 EEIGEKLHRTELATQE-KVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL 2447
Query: 417 TLAEGSLQLHLQDQA------------DRVGSTASRQR----QKAEMEQRRQKQLESLEQ 460
L +Q Q+Q S R+R +KA++EQ Q ++ +Q
Sbjct: 2448 QLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQ 2507
Query: 461 MEHPDMSLEIHYKAELEKERREQRRARL-AHLKSSSTRAQERERGSELSTTSPSGTSLAD 519
+ + + ++++ EQ R RL A ++ + R E E G
Sbjct: 2508 LRE---------EQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRK----------- 2547
Query: 520 DDRHSQMIRDQQQQILQQNRLHKQFLEEARKCLRE 554
+++ QQ+ QQ R ++ L E + LRE
Sbjct: 2548 --------QEELQQLEQQRRQQEELLAEENQRLRE 2574
Score = 30.0 bits (66), Expect = 5.8
Identities = 31/137 (22%), Positives = 56/137 (40%), Gaps = 18/137 (13%)
Query: 414 KLGTLAEGSLQLHLQDQADRVGSTASRQRQKAEMEQRRQKQLESLEQMEHPDMSLEIHYK 473
K + AE + QL Q + V R+ E E+R Q+Q E+ E + LE
Sbjct: 1559 KRASFAEKTAQLERSLQEEHVAVAQLRE----EAERRAQQQAEAERAREEAERELERWQL 1614
Query: 474 AELEKERREQRRARLAHLKSSSTRAQERERGSELSTTSPSGTSLADDDRHSQMIRDQQQQ 533
E R + +A KS + E+++ + +R ++ ++Q
Sbjct: 1615 KANEALRLRLQAEEVAQQKSLAQAEAEKQK--------------EEAEREARRRGKAEEQ 1660
Query: 534 ILQQNRLHKQFLEEARK 550
++Q L +Q LE+ R+
Sbjct: 1661 AVRQRELAEQELEKQRQ 1677
Score = 29.3 bits (64), Expect = 10.0
Identities = 21/106 (19%), Positives = 51/106 (48%), Gaps = 5/106 (4%)
Query: 398 KEDSLLYSTESGQETPKLGTLAEGSLQLHLQDQADRVGSTASRQRQKAEMEQRRQKQLES 457
+E+ L + +E +L + E +L+ Q + A +R+ E++QR Q+++
Sbjct: 1323 EEEERLAEQQRAEERERLAEV-EAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1381
Query: 458 LEQMEHPDMSLEIHYKAELEKERREQRRARLAHLKSSSTRAQERER 503
E+ K +++E ++ R++ A +++ + +A+ ER
Sbjct: 1382 REEAAVDAQ----QQKRSIQEELQQLRQSSEAEIQAKARQAEAAER 1423
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 56.2 bits (134), Expect = 8e-08
Identities = 125/587 (21%), Positives = 229/587 (39%), Gaps = 95/587 (16%)
Query: 31 LQRRADAKLWKNYQLQRLAEELRRGYQEAQH-LHVGGLDRLQSARLLGWGGGRARENEPD 89
++ A+A K LQ L EELR +EA+ L ++R + ++ R+ E E
Sbjct: 1507 VKAEAEAAREKQRALQAL-EELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQ 1565
Query: 90 SQ-GPIQRRSARPPRAKEKHRAALSEERSCREELGQQHPRHSRPRKTAASPEKPQTTKAT 148
S+ ++A+ R+ ++ A+++ R E QQ R R+ A + KA
Sbjct: 1566 SKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKAN 1625
Query: 149 GRMNSHL-------------APPEKRKGRPEPSTKSGGG--RCAIHPRRSKGADLERSNP 193
+ L A EK+K E + G A+ R +LE+
Sbjct: 1626 EALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ 1685
Query: 194 LVAAVGEIGLVEEKEKGTARAG------RRQLGKGAVCFVP--ALTSRSQGQSLEGKLRD 245
L + L E+E RA +RQL + + + A + + Q LE +L
Sbjct: 1686 LAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAK 1745
Query: 246 LG-------------------------QLWPADSSCRREAVSPASQC-TLREKNKWQKEL 279
+ Q A++ RE A++ L E+ K Q++L
Sbjct: 1746 VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQL 1805
Query: 280 ELAFEELFNINRKLKKHLCLYLALKPRMDQRPGEGHAFSEMQECGAGTPRGKKMADPEML 339
A E+ + ++ L LA + E ++E A R +++A+ E
Sbjct: 1806 --AEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEI--ALKEKEAENERLRRLAEDE-- 1859
Query: 340 PAGEPRSPAEEEAQQAASKTDLKTFMGKAQN---QKYQGTVKPTFRNGSQTLSPEAGIFI 396
A + R E+ AQ A + + KA + ++ +G V+ T R Q
Sbjct: 1860 -AFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQV--------- 1909
Query: 397 NKEDSLLYSTESGQETPKLGTLAEGSLQLHLQDQADRVGSTAS---RQRQKAEMEQRRQK 453
E+ +L S ++ A G +L L+ R+ S A R +++AE+E RQ+
Sbjct: 1910 --EEEILALKASFEKA------AAGKAELELE--LGRIRSNAEDTLRSKEQAELEAARQR 1959
Query: 454 QLESLEQMEHPDMSLEIHYKAELEKERREQRRARLAHLKSSSTRAQE----RERGS---- 505
QL + E+ + + E+E QR+A L ++ + +E RER
Sbjct: 1960 QLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESA 2019
Query: 506 ---ELSTTSPSGTSLADDDRHSQMIRDQQQQILQQNRLHKQFLEEAR 549
+L+ + A++ H+ ++ ++Q++ Q + + L++ R
Sbjct: 2020 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR 2066
Score = 35.4 bits (80), Expect = 0.14
Identities = 69/303 (22%), Positives = 118/303 (38%), Gaps = 45/303 (14%)
Query: 206 EKEKGTARAGRRQLGKGAVCFVPALTSRSQG--QSLEG-KLRDLGQLWPADSSCRREAVS 262
+++K A+ R+L + L +QG ++LE + R L A+ R A
Sbjct: 2319 QQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEM 2378
Query: 263 PASQCTLREK-NKWQKELELAFEELFNINRKLKKHLCLYLALKPRMDQRPGEGHAFSEMQ 321
+Q E +++K+ E E+L ++ + L L+ QR H ++
Sbjct: 2379 SRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI---QRQQSDHDAERLR 2435
Query: 322 ECGAGTPRGKKMADPEMLPAGEPRSPAEEEAQQAASKTDLKTFMGKAQNQKYQGTVKPTF 381
E A R K E+ QQ A LK+ ++ Q +
Sbjct: 2436 EAIAELEREK------------------EKLQQEAKLLQLKS-------EEMQTVQQEQL 2470
Query: 382 RNGSQTLSPEAGIFINKEDSLLYSTES-GQETPKLGTLAEGSLQLHLQDQADRVGSTASR 440
+Q L F++++DSLL QE KL QL + A +
Sbjct: 2471 LQETQALQQS---FLSEKDSLLQRERFIEQEKAKLE-------QLFQDEVAKAQQLREEQ 2520
Query: 441 QRQKAEMEQRRQKQLESLEQMEHPDMSLE--IHYKAELEKERREQRRARLAHLKSSSTRA 498
QRQ+ +MEQ RQ+ + S+E+ E + K E ++ +QRR + L + R
Sbjct: 2521 QRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRL 2580
Query: 499 QER 501
+E+
Sbjct: 2581 REQ 2583
Score = 34.3 bits (77), Expect = 0.31
Identities = 32/108 (29%), Positives = 50/108 (46%), Gaps = 4/108 (3%)
Query: 419 AEGSLQLHLQDQADRVGSTASRQRQKAEMEQRRQKQLESLEQMEHPDMSLEIHYKAELEK 478
AEG LQ L+ +A+ RQ Q+ RRQ Q ES ++ ++ L KAE E
Sbjct: 1457 AEGELQA-LRARAEEA-EAQKRQAQEEAERLRRQVQDES-QRKRQAEVELASRVKAEAEA 1513
Query: 479 ERREQRRAR-LAHLKSSSTRAQERERGSELSTTSPSGTSLADDDRHSQ 525
R +QR + L L+ + A+ R R +E+ +L R ++
Sbjct: 1514 AREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1561
Score = 32.3 bits (72), Expect = 1.2
Identities = 118/575 (20%), Positives = 218/575 (37%), Gaps = 74/575 (12%)
Query: 10 EDLLWRKKHKLLQARGKGDLALQRRADAKLWKNYQLQRLAEELRRGYQEAQHLHVGGLDR 69
+ L +++ L Q RG+ + A +R A+ Q +R A + RR +EA+ L ++
Sbjct: 2052 QQTLQQEQSVLDQLRGEAEAA-RRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQ 2110
Query: 70 LQSARLLGWGGGRARENEPDSQGPIQRRSARPPRAKEKHRAALSEERSCREELGQQHPRH 129
Q AR E + + R A+ +A + + A E ++ +Q R
Sbjct: 2111 AQ-ARAQAQAAAEKLRKEAEQEAA---RRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ 2166
Query: 130 SRPRKTAASPEKPQTTKATGRMNSHLAPPEKRKGRPEPSTKSGGGRCAIHPR----RSKG 185
+ + + Q + + N L E ++ + E +T++ R + R +
Sbjct: 2167 KAQVEQELTTLRLQLEETDHQKN--LLDEELQRLKAE-ATEAARQRSQVEEELFSVRVQM 2223
Query: 186 ADLERSNPLVAAVGEIGLVEEKE------KGTARAGRRQLGKGAVCFVPALTSRSQGQSL 239
+L + + A ++ +K+ + A ++ + A V A + Q
Sbjct: 2224 EELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLA 2283
Query: 240 EGKLRDLGQLWPADSSCRREAVSPASQCTLREKNKWQKELELAFEELFNINRKLKKHLCL 299
E L L + +AV A++ E Q++ ELA E+ + K+ +
Sbjct: 2284 EEDLAQQRALAEKMLKEKMQAVQEATRLKA-EAELLQQQKELAQEQARRLQED-KEQMAQ 2341
Query: 300 YLALKPRMDQRPGEGHAFSEMQECGAGTPRGKKMADPEMLPAGEPRSPAEEEAQQ---AA 356
LA + + QR E ++ E A R K+ EM A ++ AEE+AQ+ A
Sbjct: 2342 QLAEETQGFQRTLEAERQRQL-EMSAEAER-LKLRVAEMSRA---QARAEEDAQRFRKQA 2396
Query: 357 SKTDLKTFMGKAQNQKYQGTVKPTFRNGSQTLSPEAGIFINKEDSLLYSTESGQETPKLG 416
+ K + Q+ + T+ T Q +A L E Q+ KL
Sbjct: 2397 EEIGEKLHRTELATQE-KVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL 2455
Query: 417 TLAEGSLQLHLQDQA------------DRVGSTASRQR----QKAEMEQRRQKQLESLEQ 460
L +Q Q+Q S R+R +KA++EQ Q ++ +Q
Sbjct: 2456 QLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQ 2515
Query: 461 MEHPDMSLEIHYKAELEKERREQRRARL-AHLKSSSTRAQERERGSELSTTSPSGTSLAD 519
+ + + ++++ EQ R RL A ++ + R E E G
Sbjct: 2516 LRE---------EQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRK----------- 2555
Query: 520 DDRHSQMIRDQQQQILQQNRLHKQFLEEARKCLRE 554
+++ QQ+ QQ R ++ L E + LRE
Sbjct: 2556 --------QEELQQLEQQRRQQEELLAEENQRLRE 2582
Score = 30.0 bits (66), Expect = 5.8
Identities = 31/137 (22%), Positives = 56/137 (40%), Gaps = 18/137 (13%)
Query: 414 KLGTLAEGSLQLHLQDQADRVGSTASRQRQKAEMEQRRQKQLESLEQMEHPDMSLEIHYK 473
K + AE + QL Q + V R+ E E+R Q+Q E+ E + LE
Sbjct: 1567 KRASFAEKTAQLERSLQEEHVAVAQLRE----EAERRAQQQAEAERAREEAERELERWQL 1622
Query: 474 AELEKERREQRRARLAHLKSSSTRAQERERGSELSTTSPSGTSLADDDRHSQMIRDQQQQ 533
E R + +A KS + E+++ + +R ++ ++Q
Sbjct: 1623 KANEALRLRLQAEEVAQQKSLAQAEAEKQK--------------EEAEREARRRGKAEEQ 1668
Query: 534 ILQQNRLHKQFLEEARK 550
++Q L +Q LE+ R+
Sbjct: 1669 AVRQRELAEQELEKQRQ 1685
Score = 29.3 bits (64), Expect = 10.0
Identities = 21/106 (19%), Positives = 51/106 (48%), Gaps = 5/106 (4%)
Query: 398 KEDSLLYSTESGQETPKLGTLAEGSLQLHLQDQADRVGSTASRQRQKAEMEQRRQKQLES 457
+E+ L + +E +L + E +L+ Q + A +R+ E++QR Q+++
Sbjct: 1331 EEEERLAEQQRAEERERLAEV-EAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1389
Query: 458 LEQMEHPDMSLEIHYKAELEKERREQRRARLAHLKSSSTRAQERER 503
E+ K +++E ++ R++ A +++ + +A+ ER
Sbjct: 1390 REEAAVDAQ----QQKRSIQEELQQLRQSSEAEIQAKARQAEAAER 1431
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 56.2 bits (134), Expect = 8e-08
Identities = 125/587 (21%), Positives = 229/587 (39%), Gaps = 95/587 (16%)
Query: 31 LQRRADAKLWKNYQLQRLAEELRRGYQEAQH-LHVGGLDRLQSARLLGWGGGRARENEPD 89
++ A+A K LQ L EELR +EA+ L ++R + ++ R+ E E
Sbjct: 1548 VKAEAEAAREKQRALQAL-EELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQ 1606
Query: 90 SQ-GPIQRRSARPPRAKEKHRAALSEERSCREELGQQHPRHSRPRKTAASPEKPQTTKAT 148
S+ ++A+ R+ ++ A+++ R E QQ R R+ A + KA
Sbjct: 1607 SKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKAN 1666
Query: 149 GRMNSHL-------------APPEKRKGRPEPSTKSGGG--RCAIHPRRSKGADLERSNP 193
+ L A EK+K E + G A+ R +LE+
Sbjct: 1667 EALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ 1726
Query: 194 LVAAVGEIGLVEEKEKGTARAG------RRQLGKGAVCFVP--ALTSRSQGQSLEGKLRD 245
L + L E+E RA +RQL + + + A + + Q LE +L
Sbjct: 1727 LAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAK 1786
Query: 246 LG-------------------------QLWPADSSCRREAVSPASQC-TLREKNKWQKEL 279
+ Q A++ RE A++ L E+ K Q++L
Sbjct: 1787 VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQL 1846
Query: 280 ELAFEELFNINRKLKKHLCLYLALKPRMDQRPGEGHAFSEMQECGAGTPRGKKMADPEML 339
A E+ + ++ L LA + E ++E A R +++A+ E
Sbjct: 1847 --AEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEI--ALKEKEAENERLRRLAEDE-- 1900
Query: 340 PAGEPRSPAEEEAQQAASKTDLKTFMGKAQN---QKYQGTVKPTFRNGSQTLSPEAGIFI 396
A + R E+ AQ A + + KA + ++ +G V+ T R Q
Sbjct: 1901 -AFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQV--------- 1950
Query: 397 NKEDSLLYSTESGQETPKLGTLAEGSLQLHLQDQADRVGSTAS---RQRQKAEMEQRRQK 453
E+ +L S ++ A G +L L+ R+ S A R +++AE+E RQ+
Sbjct: 1951 --EEEILALKASFEKA------AAGKAELELE--LGRIRSNAEDTLRSKEQAELEAARQR 2000
Query: 454 QLESLEQMEHPDMSLEIHYKAELEKERREQRRARLAHLKSSSTRAQE----RERGS---- 505
QL + E+ + + E+E QR+A L ++ + +E RER
Sbjct: 2001 QLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESA 2060
Query: 506 ---ELSTTSPSGTSLADDDRHSQMIRDQQQQILQQNRLHKQFLEEAR 549
+L+ + A++ H+ ++ ++Q++ Q + + L++ R
Sbjct: 2061 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR 2107
Score = 35.4 bits (80), Expect = 0.14
Identities = 69/303 (22%), Positives = 118/303 (38%), Gaps = 45/303 (14%)
Query: 206 EKEKGTARAGRRQLGKGAVCFVPALTSRSQG--QSLEG-KLRDLGQLWPADSSCRREAVS 262
+++K A+ R+L + L +QG ++LE + R L A+ R A
Sbjct: 2360 QQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEM 2419
Query: 263 PASQCTLREK-NKWQKELELAFEELFNINRKLKKHLCLYLALKPRMDQRPGEGHAFSEMQ 321
+Q E +++K+ E E+L ++ + L L+ QR H ++
Sbjct: 2420 SRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI---QRQQSDHDAERLR 2476
Query: 322 ECGAGTPRGKKMADPEMLPAGEPRSPAEEEAQQAASKTDLKTFMGKAQNQKYQGTVKPTF 381
E A R K E+ QQ A LK+ ++ Q +
Sbjct: 2477 EAIAELEREK------------------EKLQQEAKLLQLKS-------EEMQTVQQEQL 2511
Query: 382 RNGSQTLSPEAGIFINKEDSLLYSTES-GQETPKLGTLAEGSLQLHLQDQADRVGSTASR 440
+Q L F++++DSLL QE KL QL + A +
Sbjct: 2512 LQETQALQQS---FLSEKDSLLQRERFIEQEKAKLE-------QLFQDEVAKAQQLREEQ 2561
Query: 441 QRQKAEMEQRRQKQLESLEQMEHPDMSLE--IHYKAELEKERREQRRARLAHLKSSSTRA 498
QRQ+ +MEQ RQ+ + S+E+ E + K E ++ +QRR + L + R
Sbjct: 2562 QRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRL 2621
Query: 499 QER 501
+E+
Sbjct: 2622 REQ 2624
Score = 34.3 bits (77), Expect = 0.31
Identities = 32/108 (29%), Positives = 50/108 (46%), Gaps = 4/108 (3%)
Query: 419 AEGSLQLHLQDQADRVGSTASRQRQKAEMEQRRQKQLESLEQMEHPDMSLEIHYKAELEK 478
AEG LQ L+ +A+ RQ Q+ RRQ Q ES ++ ++ L KAE E
Sbjct: 1498 AEGELQA-LRARAEEA-EAQKRQAQEEAERLRRQVQDES-QRKRQAEVELASRVKAEAEA 1554
Query: 479 ERREQRRAR-LAHLKSSSTRAQERERGSELSTTSPSGTSLADDDRHSQ 525
R +QR + L L+ + A+ R R +E+ +L R ++
Sbjct: 1555 AREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1602
Score = 32.3 bits (72), Expect = 1.2
Identities = 118/575 (20%), Positives = 218/575 (37%), Gaps = 74/575 (12%)
Query: 10 EDLLWRKKHKLLQARGKGDLALQRRADAKLWKNYQLQRLAEELRRGYQEAQHLHVGGLDR 69
+ L +++ L Q RG+ + A +R A+ Q +R A + RR +EA+ L ++
Sbjct: 2093 QQTLQQEQSVLDQLRGEAEAA-RRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQ 2151
Query: 70 LQSARLLGWGGGRARENEPDSQGPIQRRSARPPRAKEKHRAALSEERSCREELGQQHPRH 129
Q AR E + + R A+ +A + + A E ++ +Q R
Sbjct: 2152 AQ-ARAQAQAAAEKLRKEAEQEAA---RRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ 2207
Query: 130 SRPRKTAASPEKPQTTKATGRMNSHLAPPEKRKGRPEPSTKSGGGRCAIHPR----RSKG 185
+ + + Q + + N L E ++ + E +T++ R + R +
Sbjct: 2208 KAQVEQELTTLRLQLEETDHQKN--LLDEELQRLKAE-ATEAARQRSQVEEELFSVRVQM 2264
Query: 186 ADLERSNPLVAAVGEIGLVEEKE------KGTARAGRRQLGKGAVCFVPALTSRSQGQSL 239
+L + + A ++ +K+ + A ++ + A V A + Q
Sbjct: 2265 EELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLA 2324
Query: 240 EGKLRDLGQLWPADSSCRREAVSPASQCTLREKNKWQKELELAFEELFNINRKLKKHLCL 299
E L L + +AV A++ E Q++ ELA E+ + K+ +
Sbjct: 2325 EEDLAQQRALAEKMLKEKMQAVQEATRLKA-EAELLQQQKELAQEQARRLQED-KEQMAQ 2382
Query: 300 YLALKPRMDQRPGEGHAFSEMQECGAGTPRGKKMADPEMLPAGEPRSPAEEEAQQ---AA 356
LA + + QR E ++ E A R K+ EM A ++ AEE+AQ+ A
Sbjct: 2383 QLAEETQGFQRTLEAERQRQL-EMSAEAER-LKLRVAEMSRA---QARAEEDAQRFRKQA 2437
Query: 357 SKTDLKTFMGKAQNQKYQGTVKPTFRNGSQTLSPEAGIFINKEDSLLYSTESGQETPKLG 416
+ K + Q+ + T+ T Q +A L E Q+ KL
Sbjct: 2438 EEIGEKLHRTELATQE-KVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL 2496
Query: 417 TLAEGSLQLHLQDQA------------DRVGSTASRQR----QKAEMEQRRQKQLESLEQ 460
L +Q Q+Q S R+R +KA++EQ Q ++ +Q
Sbjct: 2497 QLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQ 2556
Query: 461 MEHPDMSLEIHYKAELEKERREQRRARL-AHLKSSSTRAQERERGSELSTTSPSGTSLAD 519
+ + + ++++ EQ R RL A ++ + R E E G
Sbjct: 2557 LRE---------EQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRK----------- 2596
Query: 520 DDRHSQMIRDQQQQILQQNRLHKQFLEEARKCLRE 554
+++ QQ+ QQ R ++ L E + LRE
Sbjct: 2597 --------QEELQQLEQQRRQQEELLAEENQRLRE 2623
Score = 30.0 bits (66), Expect = 5.8
Identities = 31/137 (22%), Positives = 56/137 (40%), Gaps = 18/137 (13%)
Query: 414 KLGTLAEGSLQLHLQDQADRVGSTASRQRQKAEMEQRRQKQLESLEQMEHPDMSLEIHYK 473
K + AE + QL Q + V R+ E E+R Q+Q E+ E + LE
Sbjct: 1608 KRASFAEKTAQLERSLQEEHVAVAQLRE----EAERRAQQQAEAERAREEAERELERWQL 1663
Query: 474 AELEKERREQRRARLAHLKSSSTRAQERERGSELSTTSPSGTSLADDDRHSQMIRDQQQQ 533
E R + +A KS + E+++ + +R ++ ++Q
Sbjct: 1664 KANEALRLRLQAEEVAQQKSLAQAEAEKQK--------------EEAEREARRRGKAEEQ 1709
Query: 534 ILQQNRLHKQFLEEARK 550
++Q L +Q LE+ R+
Sbjct: 1710 AVRQRELAEQELEKQRQ 1726
Score = 29.3 bits (64), Expect = 10.0
Identities = 21/106 (19%), Positives = 51/106 (48%), Gaps = 5/106 (4%)
Query: 398 KEDSLLYSTESGQETPKLGTLAEGSLQLHLQDQADRVGSTASRQRQKAEMEQRRQKQLES 457
+E+ L + +E +L + E +L+ Q + A +R+ E++QR Q+++
Sbjct: 1372 EEEERLAEQQRAEERERLAEV-EAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1430
Query: 458 LEQMEHPDMSLEIHYKAELEKERREQRRARLAHLKSSSTRAQERER 503
E+ K +++E ++ R++ A +++ + +A+ ER
Sbjct: 1431 REEAAVDAQ----QQKRSIQEELQQLRQSSEAEIQAKARQAEAAER 1472
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 45.4 bits (106), Expect = 1e-04
Identities = 105/541 (19%), Positives = 209/541 (38%), Gaps = 54/541 (9%)
Query: 32 QRRADAKLWKNYQLQRLAEELRRGYQE-------AQHLHVGGLDRLQSARLLGW-----G 79
Q R + +L + + +RL + L+R ++E A+ +R++S R+ W
Sbjct: 652 QERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKS-RIPKWQWQLES 710
Query: 80 GGRARENEPDSQGPIQRRSARPPRAKEKHRAALSEERSCREELGQQHPRHSRPRKTAASP 139
AR+++ S+ Q R +EK R SE + EE + + R+
Sbjct: 711 EADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQ 770
Query: 140 EKPQTTKATGRMNSHLAPP--EKRKGRPEPSTKSGGGRCAIHPRRSKGADLERSNPLVAA 197
+ + GR PP E+R+ + + + + K +R
Sbjct: 771 WQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKE---QRRRQRRER 827
Query: 198 VGEIGLVEEKEKGTARAGRRQLGKGAVCFVPALTSRSQGQSLEGKLRDLGQLWPADSSCR 257
E+ +EE+E+ R +QL + L + + + + RD W + +
Sbjct: 828 EKELQFLEEEEQLQRRERAQQLQEEE----DGLQEDQERRRSQEQRRDQKWRWQLEEERK 883
Query: 258 REAVSPASQCTLREKNKWQKELELAFEELFNINRKLKKHLCLYLALKPRMDQRPGEGHAF 317
R + ++ L+E + +KE +L EE + R+ ++ K R ++ +
Sbjct: 884 RRRHTLYAKPALQE--QLRKEQQLLQEEEEELQREERE--------KRRRQEQERQYREE 933
Query: 318 SEMQECGAGTPRGKKMADPEMLPAGEPRSPAEEEAQQAASK---TDLKTFMGKAQNQKYQ 374
++Q+ R ++ E R E E Q K + +G+ ++ +
Sbjct: 934 EQLQQEEEQLLREER----------EKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRR 983
Query: 375 GTVKPTFRNGSQTLSPEAGIFINKEDSLLYSTESGQETPKLGTLAEGSLQLHLQDQADRV 434
+ +R + L E + +E E ++ K L + QL +++ R
Sbjct: 984 QEREKKYRE-EEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRR 1042
Query: 435 GSTASRQRQKAEMEQRRQKQLESLEQMEHPDMSLEIHYKAELEKERREQRRARLAHLKSS 494
RQ ++ E Q+ ++QL E+ LE Y+ E E ++ E+ +L +
Sbjct: 1043 LQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEE---QLLREEPE 1099
Query: 495 STRAQERERG-SELSTTSPSGTSLADDDRHSQMIRDQQQQILQQNRLHKQFLEEARKCLR 553
R QERER E L ++R + ++Q++ +Q R ++ +E + LR
Sbjct: 1100 KRRRQERERQCREEEELQQEEEQLLREEREKR----RRQELERQYREEEEVQQEEEQLLR 1155
Query: 554 E 554
E
Sbjct: 1156 E 1156
Score = 44.3 bits (103), Expect = 3e-04
Identities = 108/535 (20%), Positives = 206/535 (38%), Gaps = 88/535 (16%)
Query: 32 QRRADAKLWKNYQLQRLAEELRRGYQEAQHLHVGGLDRLQSARLLGWGGGRARENEPDSQ 91
++R D +LW+ Q + EE RR +E +LQS + G E PD +
Sbjct: 166 RQRRDEELWRQRQEWQEREE-RRAEEE----------QLQSCK------GHETEEFPDEE 208
Query: 92 GPIQRRSA----RPPRAKEKHRAALSEERSCREELGQQHPRHS---RPRKTAASPEKPQT 144
++RR R R +++ + ++R +EE ++ + R + E+PQ
Sbjct: 209 -QLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQR 267
Query: 145 TKATGRMNSHLAPPEKRKGRPEPSTKSGGGRCAIHPRRSKGADLERSNPLVAAVGEIGLV 204
+ L E+++ R E + + R + L R +
Sbjct: 268 QRELQEEEEQLRKLERQELRRERQEEEQQQQ-----RLRREQQLRRKQEEERREQQEERR 322
Query: 205 EEKEKGTARAGRRQLGKGAVCFVPALTSRSQGQSLEGKLRDLGQLWPADSSCRREAVSPA 264
E++E+ + RR+ R Q + E +LR + + RRE
Sbjct: 323 EQQERREQQEERRE----------QQLRREQEERREQQLRREQEEERREQQLRREQEEER 372
Query: 265 SQCTLREKNKWQKELELAFEELFNINRKLKKHLCLYLALKPRMDQRPGEGHAFSEMQECG 324
+ LR + + ++E +L E+ ++L++ L + R +Q+ QE
Sbjct: 373 REQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQE-- 430
Query: 325 AGTPRGKKMADPEMLPAGEPRSPAEEEAQQAASKTDLKTFMGKAQNQKYQGTVKPTFRNG 384
R ++ + E E R E+E ++ K + +T + + +K Q +
Sbjct: 431 --EERHEQKHEQERR---EQRLKREQEERRDWLKREEETERHEQERRKQQ------LKRD 479
Query: 385 SQTLSPEAGIFINKEDSLLYSTESGQETPKLGTLAEGSLQLHLQDQADRVGSTASRQRQK 444
+ E + + +E+ Q+ + +Q +R RQ ++
Sbjct: 480 QEEERRERWLKLEEEERREQQERREQQLRR--------------EQEERREQRLKRQEEE 525
Query: 445 AEMEQR-RQKQLESLEQMEHPDMSLEIHYKAELEKERREQRRARLAHLKSSSTRAQERER 503
++QR R +Q EQ E + L+ + LE+ERREQR LK R QE R
Sbjct: 526 ERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQR------LK----REQEERR 575
Query: 504 GSELSTTSPSGTSLADDDRHSQMIRDQQQQILQQNRLHKQFLEEARKCLREFQNI 558
L +++R Q ++ +Q++ L+Q RL ++ +E + R Q +
Sbjct: 576 DQLLK---------REEERRQQRLKREQEERLEQ-RLKREEVERLEQEERREQRL 620
Score = 42.4 bits (98), Expect = 0.001
Identities = 112/559 (20%), Positives = 199/559 (35%), Gaps = 66/559 (11%)
Query: 32 QRRADAKLWKNYQLQRLAEELRRGYQEAQHLHVGGLDRLQSARLLGWGGGRARENEPDSQ 91
Q R + +L + QL+R EE R + Q L R Q R W R E E Q
Sbjct: 412 QLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERR-DWLK-REEETERHEQ 469
Query: 92 GPIQRRSARPPRAKEKHRAAL------SEERSCREELGQQHPRHSRPRKTAASPEKPQTT 145
+RR + R +E+ R E R +E QQ R R+ + +
Sbjct: 470 ---ERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEE 526
Query: 146 KATGRMNSHLAPPEKRKGRPEPSTKSGGGRCAIHPRRS---KGADLERSNPLVAAVGE-- 200
+ R+ S +++ R E K + RR K ER + L+ E
Sbjct: 527 RLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERR 586
Query: 201 --------------------IGLVEEKEKGTARAGRRQLGKGAVCFVPALTSRSQGQSLE 240
+ +E++E+ R R + + L S Q + +
Sbjct: 587 QQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERR--QQLLKSEEQEERRQ 644
Query: 241 GKLRDLGQLWPADSSCRREAVSPASQCTLREKNKWQKELELAFEELFNINRKLKKHLCLY 300
+LR Q R E Q RE + ++E ELA EE ++K + +
Sbjct: 645 QQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKW 704
Query: 301 L-ALKPRMDQRPGEGHAFSEMQECGAGTPRGKKMADPEMLPAGEPRSPAEEEAQQAASKT 359
L+ D R + ++ QE G R ++ + E + EE A + +
Sbjct: 705 QWQLESEADARQSKVYSRPRKQE---GQRRRQEQEEKRRRRESELQWQEEERAHRQQQEE 761
Query: 360 DLKTFMGKAQNQKYQGTVKPTFRNGSQTLSPEAGIFINKEDSLLYSTESGQETPKLGTLA 419
+ + ++ +Q + G Q LS + +E L +E
Sbjct: 762 EQR------RDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQRE-------- 807
Query: 420 EGSLQLHLQDQADRVGSTASRQRQKAEMEQRRQKQLESLEQMEHPDMSLEIHYKAELEKE 479
Q L ++ ++ RQR++ E E + ++ E L++ E E + ++E
Sbjct: 808 ----QRFLPEEEEK--EQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQE 861
Query: 480 RREQRRARLAHLKSSSTRAQERERGSELSTTSPSGTSLADDDRHSQMIRDQQQQILQQNR 539
RR + R + R Q E T + +L + R Q + ++++ LQ+
Sbjct: 862 RRRSQEQR----RDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREE 917
Query: 540 LHKQFLEEARKCLREFQNI 558
K+ +E + RE + +
Sbjct: 918 REKRRRQEQERQYREEEQL 936
Score = 40.8 bits (94), Expect = 0.003
Identities = 112/566 (19%), Positives = 208/566 (36%), Gaps = 72/566 (12%)
Query: 15 RKKHKL-----LQARGKGDLALQRRADAKLWKNYQLQRLAEELRRGYQEAQHLHVGGLDR 69
R++H L LQ + + + L + + +L + + +R +E R Y+E + L
Sbjct: 884 RRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQL 943
Query: 70 LQSARLLGWGGGRARENEPDSQGPIQRRSARPPRAKEKHRAALSEERSCREELGQQHPRH 129
L+ R R R+ D + +Q++ + + + R E+ REE Q
Sbjct: 944 LREEREKRRRQERERQYRKDKK--LQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEE 1001
Query: 130 SRPRKTAASPEKPQTTKATGRMNSHLAPPEKRKGRPEPSTKSGGGRCAIHPRRSKGADLE 189
R+ + Q + R L E++ R E + + R + + E
Sbjct: 1002 QLLREEREKRRR-QEWERQYRKKDELQQEEEQLLREEREKRR------LQERERQYREEE 1054
Query: 190 RSNPLVAAVGEIGLVEEKEKGTARAGRRQLGKGAVCFVPALTSRSQGQSLEGKLRDLGQL 249
E+ EE+ G R RR+ Q LE + R +L
Sbjct: 1055 ----------ELQQEEEQLLGEERETRRR------------------QELERQYRKEEEL 1086
Query: 250 WPADSSCRREAVSPASQCTLREKNKWQKELELAFEELFNINRKLKKHLCLYLALKPRMDQ 309
+ RE + + + ++EL+ E+L R+ ++ L + +
Sbjct: 1087 QQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEV 1146
Query: 310 RPGEGHAFSEMQECGAGTPRGKKMADPEMLPAGEPRSPAEEEAQQAASKTDLKTFMGKAQ 369
+ E E E ++ + E L E + EE+ ++ + + Q
Sbjct: 1147 QQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQ 1206
Query: 370 NQKYQGTVKPTFRNGSQTLSPEAGIFINKE----DSLLYSTESGQETPKLGTLAEGSLQL 425
QK K +R+ Q + KE D+ +Y G+E + L + L+
Sbjct: 1207 RQKR----KQRYRDEDQRSDLKWQWEPEKENAVRDNKVYC--KGRENEQFRQLEDSQLR- 1259
Query: 426 HLQDQADRVGSTASRQRQKAEMEQRR----------QKQLESLEQMEHPDMSLEIHYKAE 475
Q Q D +Q + E E+RR ++QLE EQ E + + +
Sbjct: 1260 DRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQ 1319
Query: 476 LEKERREQRRARLAHLKSSSTRAQERERGSELSTTSPSGTSLADDDRHSQMIRDQQQQ-- 533
L +E RE++R R + + + +E E+ + P D + +R Q+Q
Sbjct: 1320 LLREEREEKRRR----QETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRK 1375
Query: 534 -ILQQNRLHKQFLEEARKCLREFQNI 558
+ ++ RL +Q E RK L+E Q +
Sbjct: 1376 FLEEEQRLRRQ--ERERKFLKEEQQL 1399
Score = 40.4 bits (93), Expect = 0.004
Identities = 114/578 (19%), Positives = 211/578 (36%), Gaps = 62/578 (10%)
Query: 15 RKKHKLLQARGKGDLALQRRADAKLWKNYQLQRLAEELRRGYQEAQHLHVGGLDRLQSAR 74
R++ + Q R + +L ++ + +L + + +R +EL R Y+E + + + + +
Sbjct: 1102 RRQERERQCREEEEL---QQEEEQLLREEREKRRRQELERQYREEEEV------QQEEEQ 1152
Query: 75 LLGWGGGRARENEPDSQ----GPIQRRSARPPRAKEKHRAALSEERSCREELGQQHPRHS 130
LL + R E + Q +Q+ + R +++ R E + EE Q+ R
Sbjct: 1153 LLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQ 1212
Query: 131 RPR--------KTAASPEKPQTTK-----ATGRMNSHLAPPEKRKGRPEPSTKSGGGRCA 177
R R K PEK + GR N E + R S +
Sbjct: 1213 RYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLG 1272
Query: 178 IHPRRSKGADLERSNPLVAAVGEIGLVEEKEKGTARAGRRQLGKGAVCFVPALTSRSQGQ 237
R + + R E +E +E+ A+ R+ + + + Q
Sbjct: 1273 EQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQ 1332
Query: 238 SLEGKLRDLGQLWPADSSC---RREAVSPASQCTLREKNKWQKELELAFEELFNINRKLK 294
+ K R+ QL R+E + LR + + +K LE E+ + +
Sbjct: 1333 ETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEE--EQRLRRQERER 1390
Query: 295 KHLC--LYLALKPRMDQ-RPGEGHAFSEMQECGAGTPRGKKMADPEMLPAGEPRSPAEEE 351
K L L + R Q R F E ++ + R +K + E + R E
Sbjct: 1391 KFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLE 1450
Query: 352 AQQAASKTDLKTFMGKAQN-QKYQGTVKPTFRNGSQTLSPEAGIFINKEDSLLYSTESGQ 410
+Q + + F + Q Q+ + + L E + + D E
Sbjct: 1451 EEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRS 1510
Query: 411 ETPKLGTLAEGSLQLHLQDQADRVGSTASRQRQKAEMEQRRQKQLESLEQMEHPDMSLEI 470
+ P+ L E QLH Q QRQ+ +++ +Q + + Q D +
Sbjct: 1511 QEPERKFLEEEQ-QLHRQ------------QRQRKFLQEEQQLRRQERGQQRRQDRDRKF 1557
Query: 471 HYKAELEKERREQR-----RARLAHLKSSSTRAQERER---GSELSTTSPSGTSLADDDR 522
+ +L +ER EQ+ R R L+ R QE+ER E G +R
Sbjct: 1558 REEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQER 1617
Query: 523 ------HSQMIRDQQQQILQQNRLHKQFLEEARKCLRE 554
Q+++++++Q L + ++FLEE + R+
Sbjct: 1618 DRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQ 1655
Score = 39.3 bits (90), Expect = 0.010
Identities = 109/532 (20%), Positives = 204/532 (38%), Gaps = 75/532 (14%)
Query: 41 KNYQLQRLAEEL---RRGYQEAQHLHVGGLDRLQSARLLGWGGGRARENEPDSQGPIQRR 97
+N Q ++L + R+ Q+ QHL +R + W + R+ + ++R
Sbjct: 1246 ENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRW---QQRDRHFPEEEQLERE 1302
Query: 98 SARPPRAKEKHRAALSEERSCREELGQQHPRHSRPRKTAASPEKPQTTKATGRMNSHLAP 157
+ AK + R + E++ REE ++ R RK + Q R L
Sbjct: 1303 EQK--EAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQE-----REEQPLRR 1355
Query: 158 PEK-RKGRPEPSTKSGGGRCAIHPRRSKGADLERSNPLVAAVGEIGLVEEKEKGTARAGR 216
E+ RK R E GR LE L E ++E+++ +
Sbjct: 1356 QERDRKFREEELRHQEQGR----------KFLEEEQRLRRQERERKFLKEEQQLRCQERE 1405
Query: 217 RQLGKGAVCFVPALTSRSQGQSLEGKLRDLGQLWPADSSCRREAVSPASQCTLREKNKWQ 276
+QL + R + Q L + RD + + RR+ RE+ +
Sbjct: 1406 QQLRQDR-----DRKFREEEQQLSRQERDR-KFREEEQQVRRQE---------RERKFLE 1450
Query: 277 KELELAFEELFNINRKLKKHLCLYLALKPRMDQRPGEGHAFSEMQECGAGTPRGKKMADP 336
+E +L E +RK ++ L + + R F E ++ R +K +
Sbjct: 1451 EEQQLRQER----HRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQ 1506
Query: 337 EMLPAGEPRSPAEEEAQQAASKTDLKTFMGKAQNQKYQGTVKPTFRNGSQTLSPEAGIFI 396
E L + EP EE QQ + + F+ + Q + Q + ++ + E +
Sbjct: 1507 E-LRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQ 1565
Query: 397 NKEDSLLYSTESGQETPKLGTLAEGSLQLHLQDQADRVGSTASRQRQ-KAEMEQRRQKQL 455
+E+ L S QE + L E ++ Q++ R+++ + ++ Q R ++
Sbjct: 1566 EREEQQL----SRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKF 1621
Query: 456 ESLEQMEHPDMSLEIHYKAE----LEKE---RREQRRARLAHLKSSSTRAQER--ERGSE 506
EQ+ ++H + LE+E RR++R +L H + R +E+ + G E
Sbjct: 1622 REDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEE 1681
Query: 507 LSTTSPSGTSLADDDRHSQMIRDQQQQILQQNRLHKQFLEEARKCLREFQNI 558
L +R + R+++QQ+ +Q R RK L+E Q +
Sbjct: 1682 --------QQLRRQER-DRKFREEEQQLRRQER--------ERKFLQEEQQL 1716
Score = 34.3 bits (77), Expect = 0.31
Identities = 101/530 (19%), Positives = 185/530 (34%), Gaps = 90/530 (16%)
Query: 84 RENEPDSQGPIQRRSARPPRAKEKHRAALSEERSCREELGQQHPRHSRPRKTAASPEKPQ 143
+E E Q +RR ++ R +K R L EER R RH+ K A + +
Sbjct: 850 QEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRR--------RHTLYAKPALQEQLRK 901
Query: 144 TTKATGRMNSHLAPPEKRKGRPEPSTKSGGGRCAIHPRRSKGADLERSNPLVAAVGEIGL 203
+ L E+ K R + + R + E L
Sbjct: 902 EQQLLQEEEEELQREEREKRRRQEQERQ-----------------YREEEQLQQEEEQLL 944
Query: 204 VEEKEKGTARAGRRQLGKGAVC------FVPALTSRSQGQSLEGKLRDLGQLWPADSSCR 257
EE+EK + RQ K + + + Q E K R+ +L +
Sbjct: 945 REEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLL 1004
Query: 258 REAVSPASQCTLREKNKWQKELELAFEELF---NINRKLKKHLCLYL---ALKPRMDQRP 311
RE + + + + EL+ E+L R+L++ Y L+ +Q
Sbjct: 1005 REEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLL 1064
Query: 312 GEGHAFSEMQECGAGTPRGKKM-ADPEMLPAGEP---------RSPAEEEAQQAASKTDL 361
GE QE + +++ + E L EP R EEE Q + L
Sbjct: 1065 GEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLL 1124
Query: 362 KTFMGKAQNQKYQGTVKPTFRNGSQTLSPEAGIFINKEDSLLYSTESGQETPKLGTLAEG 421
+ K + Q+ + + + + E + +E E ++ + L +
Sbjct: 1125 REEREKRRRQELERQYRE-----EEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQE 1179
Query: 422 SLQLHLQDQADRVGSTASRQRQKAEMEQRRQKQLESLEQMEHPDMSLEIHYKAELEKE-- 479
QL ++Q R + R++ E++++++KQ + D ++ ++ E EKE
Sbjct: 1180 EEQLLREEQEKRRQERERQYREEEELQRQKRKQ-----RYRDEDQRSDLKWQWEPEKENA 1234
Query: 480 ------------------------RREQRRARLAHL---KSSSTRAQERERGSELSTTSP 512
R Q + L HL + R QER R + P
Sbjct: 1235 VRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFP 1294
Query: 513 SGTSLADDDRHSQMIRD----QQQQILQQNRLHKQFLEEARKCLREFQNI 558
L +++ RD +++Q+L++ R K+ +E + RE + +
Sbjct: 1295 EEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQL 1344
Score = 33.5 bits (75), Expect = 0.53
Identities = 28/120 (23%), Positives = 50/120 (41%), Gaps = 17/120 (14%)
Query: 430 QADRVGSTASRQRQKAEMEQRRQKQLESLEQMEHPDMSLEIHYKAELEKERREQRRARLA 489
++DR + RQ+ E +Q R +Q + + E + LE + L +ER Q RA
Sbjct: 1792 ESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLE-EQEQRLRQERDRQYRAEEQ 1850
Query: 490 HLKSSSTRAQERERGSELSTTSPSGTSLADDDRHSQMIRDQQQQILQQNRLHKQFLEEAR 549
+R +E+E E Q R ++++ L++ + +Q EE R
Sbjct: 1851 FATQEKSRREEQELWQE----------------EEQKRRQERERKLREEHIRRQQKEEQR 1894
Score = 33.1 bits (74), Expect = 0.69
Identities = 29/124 (23%), Positives = 51/124 (41%), Gaps = 3/124 (2%)
Query: 420 EGSLQLHLQDQADRVGSTASRQRQKAEMEQRRQKQLESLEQMEHPDMSLEIHYKAELEKE 479
E LQ Q++ R RQ ++ ++RRQK+ E ++ + E K E ++
Sbjct: 107 ESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSE---KQERLEQ 163
Query: 480 RREQRRARLAHLKSSSTRAQERERGSELSTTSPSGTSLADDDRHSQMIRDQQQQILQQNR 539
R QRR + + +E R E S G + Q+ R + ++ ++ R
Sbjct: 164 RDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGR 223
Query: 540 LHKQ 543
KQ
Sbjct: 224 EEKQ 227
Score = 30.8 bits (68), Expect = 3.4
Identities = 40/168 (23%), Positives = 62/168 (36%), Gaps = 18/168 (10%)
Query: 343 EPRSPAEEEAQQAASKTDLKTFMGKAQNQKYQGTVKPTFRNGSQTLSPEAGIFINKEDSL 402
E P EE Q + D K + Q+ R Q S E+ +E+ L
Sbjct: 1753 EQLRPEREEQQLRRQERDRKFREEEQLRQE---------REEQQLRSQESDRKFREEEQL 1803
Query: 403 LYSTESGQETPKL--GTLAEGSLQLHLQDQADRVGSTASRQRQKAEM---EQRRQKQLES 457
E Q P+ G QL L++Q R+ RQ + E +++ +++ +
Sbjct: 1804 RQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQE 1863
Query: 458 LEQMEHPDMSLEIHYKAELEKERR----EQRRARLAHLKSSSTRAQER 501
L Q E E K E RR EQR ++ +KS + R
Sbjct: 1864 LWQEEEQKRRQERERKLREEHIRRQQKEEQRHRQVGEIKSQEGKGHGR 1911
Score = 30.0 bits (66), Expect = 5.8
Identities = 29/117 (24%), Positives = 49/117 (41%), Gaps = 4/117 (3%)
Query: 441 QRQKAEMEQRRQKQLES---LEQMEHPDMSLEIHYKAELEKERREQRRARLAHLKSSSTR 497
+RQ+ E + R ++QL EQ+ + +I + +L ER EQ+ R +
Sbjct: 1717 RRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREE 1776
Query: 498 AQERERGSELSTTSPSGTSLADDDRHSQMIRDQQQQILQQNRLHKQFLEEARKCLRE 554
Q R+ E S ++ + R ++QQ+ Q R K EE + L E
Sbjct: 1777 EQLRQEREEQQLRSQESDRKFREEEQLRQER-EEQQLRPQQRDGKYRWEEEQLQLEE 1832
Score = 29.3 bits (64), Expect = 10.0
Identities = 29/146 (19%), Positives = 63/146 (43%), Gaps = 12/146 (8%)
Query: 420 EGSLQLHLQDQADRVGSTASRQRQKAEMEQRRQKQLESLEQMEHPDMSLEIHYKAELEKE 479
E QL Q++ +R +Q ++ E+E++ +++ + ++ E + + Y+ LE+E
Sbjct: 1695 EEEQQLRRQER-ERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEE 1753
Query: 480 -----------RREQRRARLAHLKSSSTRAQERERGSELSTTSPSGTSLADDDRHSQMIR 528
RR++R + + +E++ S+ S +R Q +R
Sbjct: 1754 QLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLR 1813
Query: 529 DQQQQILQQNRLHKQFLEEARKCLRE 554
QQ+ + + LEE + LR+
Sbjct: 1814 PQQRDGKYRWEEEQLQLEEQEQRLRQ 1839
>gi|239743649 PREDICTED: IQ motif and ankyrin repeat
domain-containing protein LOC642574 [Homo sapiens]
Length = 580
Score = 44.3 bits (103), Expect = 3e-04
Identities = 51/207 (24%), Positives = 86/207 (41%), Gaps = 11/207 (5%)
Query: 348 AEEEAQQAASKTDLKTFMGKAQNQKYQGTVKPTFRNGSQTLSPEAGIFINKEDSLLYSTE 407
A E A T F+G + + +G+ P R + + + + +
Sbjct: 7 AFREGCPAGDSTPSSPFLGAPELRARRGSQDPRRRGAGEVPADLGPLRVPGSRAASSCGL 66
Query: 408 SGQETPKLGTLAEGSLQLHLQDQADRVGSTASRQ-RQKAEMEQRRQKQLESLEQMEHPDM 466
G+E P+LG A G +D+A R A RQ R + E+ +RR+++ E LEQME P
Sbjct: 67 CGRE-PRLGR-AGGFESRPAEDRAARAIQGAFRQLRARRELARRREERREYLEQMETPQK 124
Query: 467 SLEIHYKAELEKERREQRRARLAHLKSSSTRAQERERGSELSTTSPSGTSLADDDRHSQM 526
Y A + +E+ RR R + R +E +R L + G D +
Sbjct: 125 EA---YLAPVRREQEAARRLREQEEAAQRERREELQRRRRLLDAAFDG-----DVGEIRA 176
Query: 527 IRDQQQQILQQNRLHKQFLEEARKCLR 553
+ + +Q+L + + EAR+ R
Sbjct: 177 VLKEVEQLLTREGVGHDEAGEARRLQR 203
>gi|75750474 spectrin domain with coiled-coils 1 NSP5a3b [Homo
sapiens]
Length = 987
Score = 43.5 bits (101), Expect = 5e-04
Identities = 107/500 (21%), Positives = 182/500 (36%), Gaps = 80/500 (16%)
Query: 76 LGWGGGRARENEPDSQGPIQRRSARPPRAKEKHRAALSEERSCREELGQQHPRH-SRPRK 134
+G GR + EP + +R PR + +S ERS PR S PRK
Sbjct: 1 MGNHSGRPEDPEPGAFTTTKRTGIPAPR---EFSVTVSRERSV--------PRGPSNPRK 49
Query: 135 TAASPEKPQTTKATGRMNSHLAPPEKRKGRPEPSTKSGGGRCAIHPRRSKGADLERSNPL 194
+ +SP T T + + P++ E + R + ++K +++ R
Sbjct: 50 SVSSPTSSNTPTPTKHLRTPSTKPKQENEGGEKAALESQVRELLAEAKAKDSEINRLRS- 108
Query: 195 VAAVGEIGLVEEKEKGTARAGRRQLGKGAVCFVPALTSRSQGQSLEGKLRDLGQLWPADS 254
L + KEK T A +G G D + P D+
Sbjct: 109 -------ELKKYKEKRTLNA--------------------EGTDALGPNVDGTSVSPGDT 141
Query: 255 SCRREAVSPASQCTLREKNK-WQKELELAFEELFNINRKLKKHLCLYLALKPRMD---QR 310
A L EKNK +QKEL EE NR LK+ L +YL P +
Sbjct: 142 EPMIRA--------LEEKNKNFQKELSDLEEE----NRVLKEKL-IYLEHSPNSEGAASH 188
Query: 311 PGEGHA-FSEMQECGAGTPRGKKMADP----------EMLPAGEPRSPAEEEAQQAASKT 359
G+ S QE G+P G +M+ L S +A + +
Sbjct: 189 TGDSSCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDAS 248
Query: 360 DLKTFMGKAQNQKYQGTVKPTFRNGSQTLSPEAGIFINKEDSLLYSTESGQETPKLGTLA 419
D + + ++ T P F++ + + + ++ E SL TE Q+ +
Sbjct: 249 DFEHITAETPSRPLSSTSNP-FKSSKCSTAGSSPNSVS-ELSLASLTEKIQKMEENHHST 306
Query: 420 EGSLQLHLQDQADRVGS----TASRQR---QKAEMEQRRQKQLESLEQMEHPDMSLEIHY 472
LQ LQ+ +D+ TA ++ +K +E + E EQ+ + L
Sbjct: 307 AEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQENEKLMNLL 366
Query: 473 KAELEKERREQRRARLAHLKSSSTRAQER---ERGSELSTTSPSGTSLADDDRHSQMIRD 529
+ ++ E + ++ L+ T E+ ER L+ SL + +Q +
Sbjct: 367 QERVKNEEPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEENQGALE 426
Query: 530 QQQQILQQNRLHKQFLEEAR 549
+++ ++N +FLE R
Sbjct: 427 MIKRLKEENEKLNEFLELER 446
>gi|75750468 spectrin domain with coiled-coils 1 NSP5a3a [Homo
sapiens]
Length = 709
Score = 43.5 bits (101), Expect = 5e-04
Identities = 107/500 (21%), Positives = 182/500 (36%), Gaps = 80/500 (16%)
Query: 76 LGWGGGRARENEPDSQGPIQRRSARPPRAKEKHRAALSEERSCREELGQQHPRH-SRPRK 134
+G GR + EP + +R PR + +S ERS PR S PRK
Sbjct: 1 MGNHSGRPEDPEPGAFTTTKRTGIPAPR---EFSVTVSRERSV--------PRGPSNPRK 49
Query: 135 TAASPEKPQTTKATGRMNSHLAPPEKRKGRPEPSTKSGGGRCAIHPRRSKGADLERSNPL 194
+ +SP T T + + P++ E + R + ++K +++ R
Sbjct: 50 SVSSPTSSNTPTPTKHLRTPSTKPKQENEGGEKAALESQVRELLAEAKAKDSEINRLRS- 108
Query: 195 VAAVGEIGLVEEKEKGTARAGRRQLGKGAVCFVPALTSRSQGQSLEGKLRDLGQLWPADS 254
L + KEK T A +G G D + P D+
Sbjct: 109 -------ELKKYKEKRTLNA--------------------EGTDALGPNVDGTSVSPGDT 141
Query: 255 SCRREAVSPASQCTLREKNK-WQKELELAFEELFNINRKLKKHLCLYLALKPRMD---QR 310
A L EKNK +QKEL EE NR LK+ L +YL P +
Sbjct: 142 EPMIRA--------LEEKNKNFQKELSDLEEE----NRVLKEKL-IYLEHSPNSEGAASH 188
Query: 311 PGEGHA-FSEMQECGAGTPRGKKMADP----------EMLPAGEPRSPAEEEAQQAASKT 359
G+ S QE G+P G +M+ L S +A + +
Sbjct: 189 TGDSSCPTSITQESSFGSPTGNQMSSDIDEYKKNIHGNALRTSGSSSSDVTKASLSPDAS 248
Query: 360 DLKTFMGKAQNQKYQGTVKPTFRNGSQTLSPEAGIFINKEDSLLYSTESGQETPKLGTLA 419
D + + ++ T P F++ + + + ++ E SL TE Q+ +
Sbjct: 249 DFEHITAETPSRPLSSTSNP-FKSSKCSTAGSSPNSVS-ELSLASLTEKIQKMEENHHST 306
Query: 420 EGSLQLHLQDQADRVGS----TASRQR---QKAEMEQRRQKQLESLEQMEHPDMSLEIHY 472
LQ LQ+ +D+ TA ++ +K +E + E EQ+ + L
Sbjct: 307 AEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQHRERAEQLSQENEKLMNLL 366
Query: 473 KAELEKERREQRRARLAHLKSSSTRAQER---ERGSELSTTSPSGTSLADDDRHSQMIRD 529
+ ++ E + ++ L+ T E+ ER L+ SL + +Q +
Sbjct: 367 QERVKNEEPTTQEGKIIELEQKCTGILEQGRFEREKLLNIQQQLTCSLRKVEEENQGALE 426
Query: 530 QQQQILQQNRLHKQFLEEAR 549
+++ ++N +FLE R
Sbjct: 427 MIKRLKEENEKLNEFLELER 446
>gi|32484977 angiomotin like 2 [Homo sapiens]
Length = 780
Score = 43.1 bits (100), Expect = 7e-04
Identities = 52/229 (22%), Positives = 104/229 (45%), Gaps = 28/229 (12%)
Query: 345 RSPAEEEAQQAASKTDLKTFMGKAQ--NQKYQGTVKPTFRN-GSQTLSPEAGIFINKEDS 401
R+ ++ EA + + + + M + Q N+ + ++ R S+T +AG
Sbjct: 364 RASSKREALEKTMRNKMDSEMRRLQDFNRDLRERLESANRRLASKTQEAQAGSQDMVAKL 423
Query: 402 LLYSTESGQETPKL--------GTLAEGSLQLHLQDQADRVGSTASRQRQKAEMEQRRQK 453
L S E QE KL G + + + L +QA +G+ R + E +++Q
Sbjct: 424 LAQSYEQQQEQEKLEREMALLRGAIEDQRRRAELLEQA--LGNAQGRAARAEEELRKKQA 481
Query: 454 QLESLEQMEHPDMSLEIHYKAELEKERREQRRARLA---HLKSSSTRAQERERGSELSTT 510
+E +E+++ L+ E+REQ RL + + RAQ+R+ G+ ++
Sbjct: 482 YVEKVERLQQALGQLQAAC------EKREQLELRLRTRLEQELKALRAQQRQAGAPGGSS 535
Query: 511 SPSGTSLADDDRHSQMIRDQQQQIL----QQNRLHKQFLEEARKCLREF 555
G+ R S+ +R++++QIL + +++LEE + +R+F
Sbjct: 536 GSGGSPELSALRLSEQLREKEEQILALEADMTKWEQKYLEE--RAMRQF 582
>gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens]
Length = 1312
Score = 42.7 bits (99), Expect = 9e-04
Identities = 30/114 (26%), Positives = 49/114 (42%), Gaps = 1/114 (0%)
Query: 426 HLQDQADRVGSTASRQRQKAEMEQRRQKQLESLEQMEHPDMSLEIHYKAELEKERREQRR 485
HL Q R +R++ E +QRR+++ L++ E LE E+ERR+ R
Sbjct: 389 HLLHQRQRRIEEQKEERRRVEEQQRREREQRKLQEKEQ-QRRLEDMQALRREEERRQAER 447
Query: 486 ARLAHLKSSSTRAQERERGSELSTTSPSGTSLADDDRHSQMIRDQQQQILQQNR 539
+ K + Q +L SL + Q+ + QQQQ+L +R
Sbjct: 448 EQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQLLPGDR 501
Score = 33.5 bits (75), Expect = 0.53
Identities = 32/144 (22%), Positives = 61/144 (42%), Gaps = 9/144 (6%)
Query: 407 ESGQETPKLGTLAEGSLQ---LHLQDQADRVGSTASRQRQKAEMEQRRQKQLESLEQMEH 463
E G+ + + E +L+ L LQ Q ++ S A +Q+Q+ + +Q+R + +
Sbjct: 335 EEGEPSSIMNVPGESTLRREFLRLQ-QENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQ 393
Query: 464 PDMSLEIHYKAELEKERREQRRARLAHLKSSSTRAQERERGSELSTTSPSGTSLADDDRH 523
+E K E + +QRR R + + +E++R E +R
Sbjct: 394 RQRRIE-EQKEERRRVEEQQRRER----EQRKLQEKEQQRRLEDMQALRREEERRQAERE 448
Query: 524 SQMIRDQQQQILQQNRLHKQFLEE 547
+ R Q ++ Q RL +Q +E
Sbjct: 449 QEYKRKQLEEQRQSERLQRQLQQE 472
>gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens]
Length = 1303
Score = 42.7 bits (99), Expect = 9e-04
Identities = 30/114 (26%), Positives = 49/114 (42%), Gaps = 1/114 (0%)
Query: 426 HLQDQADRVGSTASRQRQKAEMEQRRQKQLESLEQMEHPDMSLEIHYKAELEKERREQRR 485
HL Q R +R++ E +QRR+++ L++ E LE E+ERR+ R
Sbjct: 389 HLLHQRQRRIEEQKEERRRVEEQQRREREQRKLQEKEQ-QRRLEDMQALRREEERRQAER 447
Query: 486 ARLAHLKSSSTRAQERERGSELSTTSPSGTSLADDDRHSQMIRDQQQQILQQNR 539
+ K + Q +L SL + Q+ + QQQQ+L +R
Sbjct: 448 EQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQLLPGDR 501
Score = 33.5 bits (75), Expect = 0.53
Identities = 32/144 (22%), Positives = 61/144 (42%), Gaps = 9/144 (6%)
Query: 407 ESGQETPKLGTLAEGSLQ---LHLQDQADRVGSTASRQRQKAEMEQRRQKQLESLEQMEH 463
E G+ + + E +L+ L LQ Q ++ S A +Q+Q+ + +Q+R + +
Sbjct: 335 EEGEPSSIMNVPGESTLRREFLRLQ-QENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQ 393
Query: 464 PDMSLEIHYKAELEKERREQRRARLAHLKSSSTRAQERERGSELSTTSPSGTSLADDDRH 523
+E K E + +QRR R + + +E++R E +R
Sbjct: 394 RQRRIE-EQKEERRRVEEQQRRER----EQRKLQEKEQQRRLEDMQALRREEERRQAERE 448
Query: 524 SQMIRDQQQQILQQNRLHKQFLEE 547
+ R Q ++ Q RL +Q +E
Sbjct: 449 QEYKRKQLEEQRQSERLQRQLQQE 472
>gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens]
Length = 1332
Score = 42.7 bits (99), Expect = 9e-04
Identities = 30/114 (26%), Positives = 49/114 (42%), Gaps = 1/114 (0%)
Query: 426 HLQDQADRVGSTASRQRQKAEMEQRRQKQLESLEQMEHPDMSLEIHYKAELEKERREQRR 485
HL Q R +R++ E +QRR+++ L++ E LE E+ERR+ R
Sbjct: 389 HLLHQRQRRIEEQKEERRRVEEQQRREREQRKLQEKEQ-QRRLEDMQALRREEERRQAER 447
Query: 486 ARLAHLKSSSTRAQERERGSELSTTSPSGTSLADDDRHSQMIRDQQQQILQQNR 539
+ K + Q +L SL + Q+ + QQQQ+L +R
Sbjct: 448 EQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQLLPGDR 501
Score = 33.5 bits (75), Expect = 0.53
Identities = 32/144 (22%), Positives = 61/144 (42%), Gaps = 9/144 (6%)
Query: 407 ESGQETPKLGTLAEGSLQ---LHLQDQADRVGSTASRQRQKAEMEQRRQKQLESLEQMEH 463
E G+ + + E +L+ L LQ Q ++ S A +Q+Q+ + +Q+R + +
Sbjct: 335 EEGEPSSIMNVPGESTLRREFLRLQ-QENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQ 393
Query: 464 PDMSLEIHYKAELEKERREQRRARLAHLKSSSTRAQERERGSELSTTSPSGTSLADDDRH 523
+E K E + +QRR R + + +E++R E +R
Sbjct: 394 RQRRIE-EQKEERRRVEEQQRRER----EQRKLQEKEQQRRLEDMQALRREEERRQAERE 448
Query: 524 SQMIRDQQQQILQQNRLHKQFLEE 547
+ R Q ++ Q RL +Q +E
Sbjct: 449 QEYKRKQLEEQRQSERLQRQLQQE 472
>gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens]
Length = 1295
Score = 42.7 bits (99), Expect = 9e-04
Identities = 30/114 (26%), Positives = 49/114 (42%), Gaps = 1/114 (0%)
Query: 426 HLQDQADRVGSTASRQRQKAEMEQRRQKQLESLEQMEHPDMSLEIHYKAELEKERREQRR 485
HL Q R +R++ E +QRR+++ L++ E LE E+ERR+ R
Sbjct: 389 HLLHQRQRRIEEQKEERRRVEEQQRREREQRKLQEKEQ-QRRLEDMQALRREEERRQAER 447
Query: 486 ARLAHLKSSSTRAQERERGSELSTTSPSGTSLADDDRHSQMIRDQQQQILQQNR 539
+ K + Q +L SL + Q+ + QQQQ+L +R
Sbjct: 448 EQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQLLPGDR 501
Score = 33.5 bits (75), Expect = 0.53
Identities = 32/144 (22%), Positives = 61/144 (42%), Gaps = 9/144 (6%)
Query: 407 ESGQETPKLGTLAEGSLQ---LHLQDQADRVGSTASRQRQKAEMEQRRQKQLESLEQMEH 463
E G+ + + E +L+ L LQ Q ++ S A +Q+Q+ + +Q+R + +
Sbjct: 335 EEGEPSSIMNVPGESTLRREFLRLQ-QENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQ 393
Query: 464 PDMSLEIHYKAELEKERREQRRARLAHLKSSSTRAQERERGSELSTTSPSGTSLADDDRH 523
+E K E + +QRR R + + +E++R E +R
Sbjct: 394 RQRRIE-EQKEERRRVEEQQRRER----EQRKLQEKEQQRRLEDMQALRREEERRQAERE 448
Query: 524 SQMIRDQQQQILQQNRLHKQFLEE 547
+ R Q ++ Q RL +Q +E
Sbjct: 449 QEYKRKQLEEQRQSERLQRQLQQE 472
>gi|91208420 bassoon protein [Homo sapiens]
Length = 3926
Score = 42.4 bits (98), Expect = 0.001
Identities = 61/228 (26%), Positives = 95/228 (41%), Gaps = 35/228 (15%)
Query: 340 PAGEPRSPAEEEAQQAASKTDLK--TFMGKAQNQKYQGTVKPTFRNGSQTLSPEAGIFIN 397
P G R PA A+S + ++GK K G P+ PE +
Sbjct: 2255 PTGLYRYPAPSRFPIASSVPPAEGPVYLGKPAAAKAPGAGGPS--------RPEMPVGAA 2306
Query: 398 KEDSLLYSTESG-QETPKLGTLAEGSLQLHLQDQADRVGSTA-SR---QRQKAEMEQRRQ 452
+E+ L +T + +E A + Q D A GS A SR ++++A E+R++
Sbjct: 2307 REEPLPTTTPAAIKEAAGAPAPAPLAGQKPPADAAPGGGSGALSRPGFEKEEASQEERQR 2366
Query: 453 KQLESLEQMEHPDMSLE----IHYKAELEKERREQRRAR-------------LAHLKSSS 495
KQ E L Q+E + LE + + ELE+ER E +R R L +K
Sbjct: 2367 KQQEQLLQLERERVELEKLRQLRLQEELERERVELQRHREEEQLLVQRELQELQTIKHHV 2426
Query: 496 TRAQERERGSELSTTSPSGTSLADDDRHSQMIRDQQQQILQQNRLHKQ 543
+ Q+ ER ++ + LA + I+ QQQ+ QQ KQ
Sbjct: 2427 LQQQQEERQAQFAL---QREQLAQQRLQLEQIQQLQQQLQQQLEEQKQ 2471
Score = 33.9 bits (76), Expect = 0.40
Identities = 33/131 (25%), Positives = 61/131 (46%), Gaps = 17/131 (12%)
Query: 427 LQDQADRVGSTASRQRQKAEMEQRRQKQLES----LEQMEHPDMSLEIHYKAELEKERRE 482
L++ +D S+ SR+++ E +Q+R+ + S L +E E+ + EL +E+ +
Sbjct: 1002 LEEDSD---SSPSRRQRLEEAKQQRKARHRSHGPLLPTIEDSSEEEELREEEELLREQEK 1058
Query: 483 QRRARLAHLKSSS--TRAQERE----RGSELSTTSPSGTSLADDDRHSQMIRDQQQQILQ 536
R ++S++ TR + E R E S T PS S +D ++ +R Q +
Sbjct: 1059 MREVEQQRIRSTARKTRRDKEELRAQRRRERSKTPPSNLSPIEDASPTEELR----QAAE 1114
Query: 537 QNRLHKQFLEE 547
LH+ E
Sbjct: 1115 MEELHRSSCSE 1125
>gi|4827046 U2 small nuclear RNA auxiliary factor 1-like 2 [Homo
sapiens]
Length = 482
Score = 42.0 bits (97), Expect = 0.001
Identities = 25/98 (25%), Positives = 47/98 (47%), Gaps = 15/98 (15%)
Query: 459 EQMEHPDMSLEIHYKAELEKERREQRRARLAHLKSSSTRAQERERGSELSTTSPSGTSLA 518
E+M P+ Y+A L+KE+R++RR LA L+ S +E E + +
Sbjct: 5 EKMTFPEKPSHKKYRAALKKEKRKKRRQELARLRDSGLSQKEEEEDTFIE---------- 54
Query: 519 DDDRHSQMIRDQQQQILQQNRLHKQFLEEARKCLREFQ 556
Q + +++ ++ RLH+++L +K EF+
Sbjct: 55 -----EQQLEEEKLLERERQRLHEEWLLREQKAQEEFR 87
>gi|102467235 inner centromere protein antigens 135/155kDa isoform 1
[Homo sapiens]
Length = 918
Score = 41.2 bits (95), Expect = 0.003
Identities = 30/113 (26%), Positives = 50/113 (44%), Gaps = 11/113 (9%)
Query: 442 RQKAEMEQRRQKQLESLEQMEHPDMSLEIHYKAELEKERREQRRARLAHLKSSSTRAQER 501
R+K E E RR + L+ E+ L+ + E E+ R+ RLA + R QER
Sbjct: 638 RRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQER 697
Query: 502 ERGSELSTTSPSGTSLADDDRHSQMIRDQQQQILQQNRLHKQFLEEARKCLRE 554
+ +R Q R+Q++Q+ +Q R +Q +A + L+E
Sbjct: 698 REQER-----------REQERREQERREQERQLAEQERRREQERLQAERELQE 739
Score = 35.4 bits (80), Expect = 0.14
Identities = 29/118 (24%), Positives = 52/118 (44%), Gaps = 4/118 (3%)
Query: 441 QRQKAEMEQRRQKQLES---LEQMEHPDMSLEIHYKAELEKERREQRRARLAHLKSSSTR 497
Q++K E ++R +K E+ EQ E E + E+ERREQ R + R
Sbjct: 665 QKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQER 724
Query: 498 AQERER-GSELSTTSPSGTSLADDDRHSQMIRDQQQQILQQNRLHKQFLEEARKCLRE 554
+E+ER +E ++ + + +++++ QQ +Q EE K +E
Sbjct: 725 RREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKE 782
Score = 33.9 bits (76), Expect = 0.40
Identities = 22/117 (18%), Positives = 59/117 (50%), Gaps = 9/117 (7%)
Query: 441 QRQKAEMEQRRQKQLESLEQMEHPDMSLEIHYKAE-LEKERREQRRARLAHLKSSSTRAQ 499
+RQK E ++RR+ + L++ E L+ + E +++E+++Q + A + + +A+
Sbjct: 555 RRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAK 614
Query: 500 ERERGSELSTTSPSGTSLAD------DDRHSQMIRDQQQQILQQNRLHKQFLEEARK 550
E E + + + + + ++ +R QQ+ ++ R H++ L++ ++
Sbjct: 615 EERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQE--EEERRHQELLQKKKE 669
Score = 32.3 bits (72), Expect = 1.2
Identities = 18/66 (27%), Positives = 41/66 (62%), Gaps = 4/66 (6%)
Query: 428 QDQADRVGSTASRQRQKAEMEQRR-QKQLESLEQMEHPDMSLEI---HYKAELEKERREQ 483
++Q R ++RQ AE E+RR Q++L++ +++ + +L + + ELE++++++
Sbjct: 703 REQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKE 762
Query: 484 RRARLA 489
+ RLA
Sbjct: 763 EQQRLA 768
>gi|102467242 inner centromere protein antigens 135/155kDa isoform 2
[Homo sapiens]
Length = 914
Score = 41.2 bits (95), Expect = 0.003
Identities = 30/113 (26%), Positives = 50/113 (44%), Gaps = 11/113 (9%)
Query: 442 RQKAEMEQRRQKQLESLEQMEHPDMSLEIHYKAELEKERREQRRARLAHLKSSSTRAQER 501
R+K E E RR + L+ E+ L+ + E E+ R+ RLA + R QER
Sbjct: 634 RRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQER 693
Query: 502 ERGSELSTTSPSGTSLADDDRHSQMIRDQQQQILQQNRLHKQFLEEARKCLRE 554
+ +R Q R+Q++Q+ +Q R +Q +A + L+E
Sbjct: 694 REQER-----------REQERREQERREQERQLAEQERRREQERLQAERELQE 735
Score = 35.4 bits (80), Expect = 0.14
Identities = 29/118 (24%), Positives = 52/118 (44%), Gaps = 4/118 (3%)
Query: 441 QRQKAEMEQRRQKQLES---LEQMEHPDMSLEIHYKAELEKERREQRRARLAHLKSSSTR 497
Q++K E ++R +K E+ EQ E E + E+ERREQ R + R
Sbjct: 661 QKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQER 720
Query: 498 AQERER-GSELSTTSPSGTSLADDDRHSQMIRDQQQQILQQNRLHKQFLEEARKCLRE 554
+E+ER +E ++ + + +++++ QQ +Q EE K +E
Sbjct: 721 RREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKE 778
Score = 33.9 bits (76), Expect = 0.40
Identities = 22/117 (18%), Positives = 59/117 (50%), Gaps = 9/117 (7%)
Query: 441 QRQKAEMEQRRQKQLESLEQMEHPDMSLEIHYKAE-LEKERREQRRARLAHLKSSSTRAQ 499
+RQK E ++RR+ + L++ E L+ + E +++E+++Q + A + + +A+
Sbjct: 551 RRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAK 610
Query: 500 ERERGSELSTTSPSGTSLAD------DDRHSQMIRDQQQQILQQNRLHKQFLEEARK 550
E E + + + + + ++ +R QQ+ ++ R H++ L++ ++
Sbjct: 611 EERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQE--EEERRHQELLQKKKE 665
Score = 32.3 bits (72), Expect = 1.2
Identities = 18/66 (27%), Positives = 41/66 (62%), Gaps = 4/66 (6%)
Query: 428 QDQADRVGSTASRQRQKAEMEQRR-QKQLESLEQMEHPDMSLEI---HYKAELEKERREQ 483
++Q R ++RQ AE E+RR Q++L++ +++ + +L + + ELE++++++
Sbjct: 699 REQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKE 758
Query: 484 RRARLA 489
+ RLA
Sbjct: 759 EQQRLA 764
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 40.4 bits (93), Expect = 0.004
Identities = 38/144 (26%), Positives = 66/144 (45%), Gaps = 9/144 (6%)
Query: 420 EGSLQLHLQDQADRVGSTASRQRQKAEMEQRRQKQLESLEQMEHPDMSLEIHYK---AEL 476
EG L Q A R++ + E +Q+ ++LE +E M LE+ K E+
Sbjct: 839 EGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEM 898
Query: 477 E--KERREQRRARLAHLKSSSTRAQERERGSELSTTSPSGTSLADDDRHSQMIR-DQQQQ 533
E + +RE+ R + E+ER S L T + LAD + + +R D + Q
Sbjct: 899 EAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQ 958
Query: 534 ILQQNR---LHKQFLEEARKCLRE 554
L++ + + L+EA++ L+E
Sbjct: 959 KLKEQETTGILQTQLQEAQRELKE 982
Score = 35.8 bits (81), Expect = 0.11
Identities = 112/571 (19%), Positives = 207/571 (36%), Gaps = 101/571 (17%)
Query: 21 LQARGKGDLALQRRADAKLWKNYQLQRLAEELRRGYQEAQHLHVGGLDRLQSARLLGWGG 80
L A+ +++ KL + + R+ +EL R E L + +++ Q +L
Sbjct: 1019 LVAQDDSQRLVEQEVQEKLRETQEYNRIQKELER---EKASLTLSLMEKEQRLLVLQEAD 1075
Query: 81 G-------RARENEPDSQGPIQRRSARPP----RAKEKHRAALSEERSCREELGQQHPRH 129
R++ ++QG + SA+ KEK L++E EEL H
Sbjct: 1076 SIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITE 1135
Query: 130 SRPRKT-------------------------AASPEKPQTTKATGRMNSHLAPPEKRKG- 163
+ R + AA + +A ++ S + ++ G
Sbjct: 1136 QQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGS 1195
Query: 164 ----RPEPSTKSGGGRCA-----IHPRRSKGADLERSNPLVAAVGEIGLVEEKEKGTARA 214
RPE SGGG A + P ++ L + PL+ A+ + K
Sbjct: 1196 VCESRPE---LSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDL 1252
Query: 215 GRRQLGKGAVCFVPALTSRSQGQSLEGKLRDLGQLWPADSSCRREAVSPASQCTLREKNK 274
+ Q + + R Q Q LE +L D + ++ SQ EK+K
Sbjct: 1253 WKTQQTRDVL--------RDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQ-NQEEKSK 1303
Query: 275 WQKELELAFEELFNINRKLKKHLCLYLALKPRMDQRPGEGHAFSEMQECGAGTPRGKKMA 334
W+ + EL ++ + +L+ R+ + +E+Q R +
Sbjct: 1304 WEGKQNSLESELMELHETMA-------SLQSRLRR--------AELQ-------RMEAQG 1341
Query: 335 DPEMLPAGEPRSPAEEEAQQAASKTDLKTFMGKAQNQKYQGTVKPTFRNGSQTLSPEAGI 394
+ E+L A + A+ E QAA +AQ G ++ R L +
Sbjct: 1342 ERELLQAAKENLTAQVEHLQAA------VVEARAQASA-AGILEEDLRTARSALKLKNEE 1394
Query: 395 FINKEDSLLYSTESGQETPKLGTLAEGSLQLHLQDQADRVGSTASRQRQKAEMEQRRQKQ 454
++ + E G+ G + +L L Q A+R + + Q E+E++R+ Q
Sbjct: 1395 VESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQ 1454
Query: 455 LESLE------QMEHPDMSLEIHYKAELEKERREQRRARLAHLKSSSTRAQERERGSELS 508
+LE + + ++ L+ ELEK R +A + +RE+ EL
Sbjct: 1455 KAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELE 1514
Query: 509 TTSPSGTS-----LADDDRHSQMIRDQQQQI 534
+ + L + ++ QMI Q+ Q+
Sbjct: 1515 KDRETQRNVLEHQLLELEKKDQMIESQRGQV 1545
Score = 31.6 bits (70), Expect = 2.0
Identities = 33/145 (22%), Positives = 63/145 (43%), Gaps = 21/145 (14%)
Query: 423 LQLHLQDQADRVGSTASRQRQKAEMEQRRQKQLESLEQMEHPDMSLEIHYKAELEKERRE 482
L LQ++ V S QR++ E QR+++ L + +E D L + + E +
Sbjct: 1621 LARELQERDQEVKS----QREQIEELQRQKEHL--TQDLERRDQELMLQKERIQVLEDQR 1674
Query: 483 QRRARLAHLKSSSTRAQERERGSELST------------TSPSGTSLADDDRHSQMIRDQ 530
R+ ++ + RERG EL+T PS + ++RD+
Sbjct: 1675 TRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDK 1734
Query: 531 QQQI-LQQNRLHKQFLEEARKCLRE 554
++++ QQ +H+ L+E + L +
Sbjct: 1735 EKEVECQQEHIHE--LQELKDQLEQ 1757
>gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens]
Length = 1220
Score = 40.4 bits (93), Expect = 0.004
Identities = 41/165 (24%), Positives = 71/165 (43%), Gaps = 10/165 (6%)
Query: 401 SLLYSTESGQETPKLGTLAEGSLQLHLQDQADRVGSTASR-QRQKAEMEQRRQKQLESLE 459
S++ ST Q P+ L + QL + +R E+E+RRQ LE
Sbjct: 318 SVISSTSVDQRLPEEPVLEDEQQQLEKKLPVTFEDKKRENFERGNLELEKRRQALLEQQR 377
Query: 460 QMEHPDMSLEIHYKAELEKERREQRRARLAHLKS------SSTRAQERERGSELSTTSPS 513
+ + LE + E+ER+EQ R R L+ R +E ER E+ +
Sbjct: 378 KEQERLAQLERAEQERKERERQEQERKRQLELEKQLEKQRELERQREEERRKEIERREAA 437
Query: 514 GTSLADDDRHSQMIRDQQQQILQQNRLHKQ--FLEEARKCLREFQ 556
L + R + R+++Q++L Q ++ + +A+K EF+
Sbjct: 438 KREL-ERQRQLEWERNRRQELLNQRNKEQEDIVVLKAKKKTLEFE 481
Score = 31.2 bits (69), Expect = 2.6
Identities = 17/76 (22%), Positives = 35/76 (46%), Gaps = 4/76 (5%)
Query: 426 HLQDQADRVGSTASRQRQKAEMEQRRQKQLESLEQMEHPDMSLEIHYKAELEKERREQRR 485
HL+DQ D V + Q+ ++ + K+L + H L+ E E+ +++++
Sbjct: 581 HLRDQLDEVEKETRSKLQEIDIFNNQLKELREI----HNKQQLQKQKSMEAERLKQKEQE 636
Query: 486 ARLAHLKSSSTRAQER 501
++ L+ AQ R
Sbjct: 637 RKIIELEKQKEEAQRR 652
>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
Length = 1721
Score = 40.4 bits (93), Expect = 0.004
Identities = 41/165 (24%), Positives = 71/165 (43%), Gaps = 10/165 (6%)
Query: 401 SLLYSTESGQETPKLGTLAEGSLQLHLQDQADRVGSTASR-QRQKAEMEQRRQKQLESLE 459
S++ ST Q P+ L + QL + +R E+E+RRQ LE
Sbjct: 318 SVISSTSVDQRLPEEPVLEDEQQQLEKKLPVTFEDKKRENFERGNLELEKRRQALLEQQR 377
Query: 460 QMEHPDMSLEIHYKAELEKERREQRRARLAHLKS------SSTRAQERERGSELSTTSPS 513
+ + LE + E+ER+EQ R R L+ R +E ER E+ +
Sbjct: 378 KEQERLAQLERAEQERKERERQEQERKRQLELEKQLEKQRELERQREEERRKEIERREAA 437
Query: 514 GTSLADDDRHSQMIRDQQQQILQQNRLHKQ--FLEEARKCLREFQ 556
L + R + R+++Q++L Q ++ + +A+K EF+
Sbjct: 438 KREL-ERQRQLEWERNRRQELLNQRNKEQEDIVVLKAKKKTLEFE 481
Score = 31.2 bits (69), Expect = 2.6
Identities = 17/76 (22%), Positives = 35/76 (46%), Gaps = 4/76 (5%)
Query: 426 HLQDQADRVGSTASRQRQKAEMEQRRQKQLESLEQMEHPDMSLEIHYKAELEKERREQRR 485
HL+DQ D V + Q+ ++ + K+L + H L+ E E+ +++++
Sbjct: 581 HLRDQLDEVEKETRSKLQEIDIFNNQLKELREI----HNKQQLQKQKSMEAERLKQKEQE 636
Query: 486 ARLAHLKSSSTRAQER 501
++ L+ AQ R
Sbjct: 637 RKIIELEKQKEEAQRR 652
>gi|239757626 PREDICTED: hypothetical protein XP_002345507 [Homo
sapiens]
Length = 609
Score = 40.0 bits (92), Expect = 0.006
Identities = 46/160 (28%), Positives = 66/160 (41%), Gaps = 24/160 (15%)
Query: 88 PDSQGPIQR---RSARPPR-AKEKHR----AALSEERSCREELGQQHPRHSRPRKTAASP 139
P + GP+ R RSARPPR + +HR A + R E G R + P
Sbjct: 422 PLALGPLPRPGLRSARPPRQCRGEHRLGPHAPMPSPRCPGEAQGVTDGRRASPSAPGGDQ 481
Query: 140 EKPQTTK------ATGRMNSHLAPPEKRKGRPEPSTKSGGGRCAIHPRRSKGADLERSNP 193
++ TT +G P +KR GR + R A RR GA ++ P
Sbjct: 482 DRVSTTPQPTAQPGSGAGPQRPGPTQKRGGRGVRVPEGSPARIAFSGRRG-GA---KAQP 537
Query: 194 LVAAVGEIGLVEEKEKGTARAGR-----RQLGKGAVCFVP 228
+ A +G E ++ G A G R +G+GA+C P
Sbjct: 538 MAEAES-LGDRERRDGGGAAGGGAVAQLRAVGQGALCAAP 576
>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 899
Score = 40.0 bits (92), Expect = 0.006
Identities = 24/118 (20%), Positives = 56/118 (47%), Gaps = 1/118 (0%)
Query: 427 LQDQADRVGSTASRQRQKAEMEQRRQKQLESLEQM-EHPDMSLEIHYKAELEKERREQRR 485
++DQ +R+ R R+K E + ++K E +E+M E M + + E++ +E+ R
Sbjct: 392 MRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEER 451
Query: 486 ARLAHLKSSSTRAQERERGSELSTTSPSGTSLADDDRHSQMIRDQQQQILQQNRLHKQ 543
R K RE+ ++ + + + Q + +Q++++ +Q ++ +Q
Sbjct: 452 IREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQ 509
Score = 32.7 bits (73), Expect = 0.90
Identities = 27/161 (16%), Positives = 70/161 (43%), Gaps = 8/161 (4%)
Query: 398 KEDSLLYSTESGQETPKLGTLAEGSLQLHLQDQADRVGSTASRQRQKAEMEQRRQKQLES 457
+ED + E ++ + E ++ Q+Q + + R++ M +R +K E
Sbjct: 542 QEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREE 601
Query: 458 LEQM-EHPDMSLEIHYKAELEKERREQRRARLAHLKSSSTRAQER-----ERGSELSTTS 511
E M E + E K + ++E+ ++ ++ + +E+ E+ E
Sbjct: 602 EEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLP 661
Query: 512 PSGTSLADDDR--HSQMIRDQQQQILQQNRLHKQFLEEARK 550
L + ++ + +++Q+++I +Q ++ K+ E+ +K
Sbjct: 662 EQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKK 702
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 40.0 bits (92), Expect = 0.006
Identities = 63/301 (20%), Positives = 122/301 (40%), Gaps = 40/301 (13%)
Query: 266 QCTLREKNKWQKELELAFEELFNINRKLKKHLCLYLALKPRMDQRPGEGHAFSEMQECGA 325
Q TL NK ++LE ++L N+ L+K+L R++Q E
Sbjct: 769 QKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKE------------ 816
Query: 326 GTPRGKKMADPEMLPAGEPRSPAEEEAQQAASKTDLKTFMGKAQNQKYQGTVKPTFRNGS 385
K + E + + E+E ++ + ++K + N K K +
Sbjct: 817 -----NKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKE-----N 866
Query: 386 QTLSPEAGIFINKEDSLLYSTESGQETPKLGTLAEGSLQLHLQDQADRVGSTASRQRQKA 445
+TLS E GI+ ++S + E +E +L A ++ + + D V Q+
Sbjct: 867 KTLSKEIGIY---KESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNN 923
Query: 446 EMEQRRQKQLESL----EQMEHPDMSLEIHYK---AELEK------ERREQRRARLAHLK 492
++E + +LE + E++ H + S + YK ++LE E +E++ A L
Sbjct: 924 DLE-KLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARL 982
Query: 493 SSSTRAQERERGSELSTTSPSGTSLADDDRHSQMIRDQQQQILQQNRLHKQFLEEARKCL 552
ST ++ R EL T + +L +M++ + N+ ++ E R+ L
Sbjct: 983 EESTNYNQQLR-QELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELL 1041
Query: 553 R 553
+
Sbjct: 1042 K 1042
>gi|42542379 serine/arginine repetitive matrix 1 [Homo sapiens]
Length = 904
Score = 40.0 bits (92), Expect = 0.006
Identities = 31/121 (25%), Positives = 52/121 (42%), Gaps = 9/121 (7%)
Query: 93 PIQRRSARPPRAKEKHRAALSEERSCREELGQQHPRHSRPRKTAASPEKPQTTKATGRMN 152
P RRS P R + + A+LS S + P P++T++ P K T R++
Sbjct: 336 PRHRRSRSPVRRRRRSSASLSGSSSSSSSSRSRSPPKKPPKRTSSPPRK------TRRLS 389
Query: 153 SHLAPPEKRKGRPEPSTKSGGGRCAIHPRRSKGADLERSNPLVAAVGEIGLVEEKEKGTA 212
+PP +R P+T R + P++S + R + + + G K KGT
Sbjct: 390 PSASPPRRRHRPSPPATPPPKTRHSPTPQQS---NRTRKSRVSVSPGRTSGKVTKHKGTE 446
Query: 213 R 213
+
Sbjct: 447 K 447
Score = 37.4 bits (85), Expect = 0.037
Identities = 25/91 (27%), Positives = 40/91 (43%), Gaps = 7/91 (7%)
Query: 82 RARENEPDSQ--GPIQRRSARPPRAKEKHRAALSEERSCREELGQQHPRHSRPRKTAASP 139
R + P Q P+ +R R P KHR S RS RE + P+ ++ + P
Sbjct: 634 RVSHSPPPKQRSSPVTKR--RSPSLSSKHRKGSSPSRSTRE---ARSPQPNKRHSPSPRP 688
Query: 140 EKPQTTKATGRMNSHLAPPEKRKGRPEPSTK 170
PQT+ + + + +R+ P PST+
Sbjct: 689 RAPQTSSSPPPVRRGASSSPQRRQSPSPSTR 719
Score = 34.7 bits (78), Expect = 0.24
Identities = 24/108 (22%), Positives = 43/108 (39%), Gaps = 5/108 (4%)
Query: 88 PDSQGPIQRRSARPPRAKEKHRAALSEERSCREELGQQHPRHSRPRKTAASPEKPQTTKA 147
P+ + P ++++ + KEK R R + P H+RPR+ S + + +
Sbjct: 254 PEPKEPSPEKNSKKEKEKEKTRPRSRSRSKSRSRTRSRSPSHTRPRRRHRSRSRSYSPRR 313
Query: 148 TGRMNSHLAPPEKRKGRPE---PSTKSGGGRCAIHPRRSKGADLERSN 192
R + P +R+ P P + R + RR A L S+
Sbjct: 314 --RPSPRRRPSPRRRTPPRRMPPPPRHRRSRSPVRRRRRSSASLSGSS 359
Score = 32.0 bits (71), Expect = 1.5
Identities = 28/103 (27%), Positives = 40/103 (38%), Gaps = 11/103 (10%)
Query: 84 RENEPDSQGPIQRRSARPPRAKEKHRAALSEERSCREELGQQHPRHSRPRKTAASPEKPQ 143
R+N+ S S+ R K H E+G++ RHS R + SP K Q
Sbjct: 487 RQNQQSSSDSGSSSSSEDERPKRSHVK--------NGEVGRRR-RHSPSRSASPSPRKRQ 537
Query: 144 --TTKATGRMNSHLAPPEKRKGRPEPSTKSGGGRCAIHPRRSK 184
T+ R S PP +R+ P P+ R P R +
Sbjct: 538 KETSPRGRRRRSPSPPPTRRRRSPSPAPPPRRRRTPTPPPRRR 580
Score = 30.4 bits (67), Expect = 4.5
Identities = 21/89 (23%), Positives = 32/89 (35%)
Query: 82 RARENEPDSQGPIQRRSARPPRAKEKHRAALSEERSCREELGQQHPRHSRPRKTAASPEK 141
R R+ E +G +R + PP + + + R R R P SP
Sbjct: 534 RKRQKETSPRGRRRRSPSPPPTRRRRSPSPAPPPRRRRTPTPPPRRRTPSPPPRRRSPSP 593
Query: 142 PQTTKATGRMNSHLAPPEKRKGRPEPSTK 170
+ + R S PP++R P P K
Sbjct: 594 RRYSPPIQRRYSPSPPPKRRTASPPPPPK 622
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.128 0.370
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,718,908
Number of Sequences: 37866
Number of extensions: 1223713
Number of successful extensions: 8169
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 108
Number of HSP's successfully gapped in prelim test: 480
Number of HSP's that attempted gapping in prelim test: 6147
Number of HSP's gapped (non-prelim): 1882
length of query: 559
length of database: 18,247,518
effective HSP length: 107
effective length of query: 452
effective length of database: 14,195,856
effective search space: 6416526912
effective search space used: 6416526912
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.