Search of human proteins with 239751247

Search of human proteins with 239751247

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|239751247 PREDICTED: similar to mitogen-activated protein
kinase kinase 3 [Homo sapiens]
         (198 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|239751247 PREDICTED: similar to mitogen-activated protein kin...   414   e-116
gi|21618347 mitogen-activated protein kinase kinase 3 isoform A ...   310   7e-85
gi|21618349 mitogen-activated protein kinase kinase 3 isoform B ...   310   7e-85
gi|239757989 PREDICTED: similar to MAP kinase 3c [Homo sapiens]       307   3e-84
gi|14589900 mitogen-activated protein kinase kinase 6 [Homo sapi...   280   7e-76
gi|4506889 mitogen-activated protein kinase kinase 4 [Homo sapiens]   213   1e-55
gi|21735544 mitogen-activated protein kinase kinase 7 [Homo sapi...   152   1e-37
gi|13489054 mitogen-activated protein kinase kinase 2 [Homo sapi...   132   1e-31
gi|5579478 mitogen-activated protein kinase kinase 1 [Homo sapiens]   131   4e-31
gi|4506101 mitogen-activated protein kinase kinase 5 isoform B [...   127   6e-30
gi|21729895 mitogen-activated protein kinase kinase 5 isoform A ...   126   1e-29
gi|103471999 serine/threonine kinase 3 [Homo sapiens]                 103   1e-22
gi|5454096 serine/threonine kinase 4 [Homo sapiens]                   102   3e-22
gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens]       86   2e-17
gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens]        86   2e-17
gi|21361358 serine/threonine kinase 25 [Homo sapiens]                  85   4e-17
gi|19424132 NIMA-related kinase 7 [Homo sapiens]                       85   5e-17
gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo...    84   8e-17
gi|22035600 mitogen-activated protein kinase kinase kinase kinas...    83   1e-16
gi|126362971 serine/threonine kinase 10 [Homo sapiens]                 83   2e-16
gi|32455269 serine/threonine kinase 32C [Homo sapiens]                 83   2e-16
gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Ho...    80   9e-16
gi|222418622 NIMA-related kinase 6 isoform 1 [Homo sapiens]            80   9e-16
gi|19923407 NIMA-related kinase 6 isoform 2 [Homo sapiens]             80   9e-16
gi|134288915 myosin IIIB isoform 1 [Homo sapiens]                      80   1e-15
gi|134288892 myosin IIIB isoform 2 [Homo sapiens]                      80   1e-15
gi|8923754 serine/threonine kinase 32B [Homo sapiens]                  79   2e-15
gi|163310763 serine/threonine kinase 32A isoform 1 [Homo sapiens]      79   3e-15
gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1 is...    79   3e-15
gi|20149547 ribosomal protein S6 kinase, 90kDa, polypeptide 1 is...    79   3e-15

>gi|239751247 PREDICTED: similar to mitogen-activated protein kinase
           kinase 3 [Homo sapiens]
          Length = 198

 Score =  414 bits (1064), Expect = e-116
 Identities = 198/198 (100%), Positives = 198/198 (100%)

Query: 1   MDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDKFYRKVLDKNMTIPEDILGE 60
           MDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDKFYRKVLDKNMTIPEDILGE
Sbjct: 1   MDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDKFYRKVLDKNMTIPEDILGE 60

Query: 61  IAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCK 120
           IAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCK
Sbjct: 61  IAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCK 120

Query: 121 PYMAPERINPELNQKGYNVKSDVWSLGITMQKVCCRWRPGTLRWGGRKGGWALNPGPAEA 180
           PYMAPERINPELNQKGYNVKSDVWSLGITMQKVCCRWRPGTLRWGGRKGGWALNPGPAEA
Sbjct: 121 PYMAPERINPELNQKGYNVKSDVWSLGITMQKVCCRWRPGTLRWGGRKGGWALNPGPAEA 180

Query: 181 KGIPGLGRVRADVAEVQV 198
           KGIPGLGRVRADVAEVQV
Sbjct: 181 KGIPGLGRVRADVAEVQV 198


>gi|21618347 mitogen-activated protein kinase kinase 3 isoform A
           [Homo sapiens]
          Length = 318

 Score =  310 bits (793), Expect = 7e-85
 Identities = 150/150 (100%), Positives = 150/150 (100%)

Query: 1   MDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDKFYRKVLDKNMTIPEDILGE 60
           MDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDKFYRKVLDKNMTIPEDILGE
Sbjct: 80  MDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDKFYRKVLDKNMTIPEDILGE 139

Query: 61  IAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCK 120
           IAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCK
Sbjct: 140 IAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCK 199

Query: 121 PYMAPERINPELNQKGYNVKSDVWSLGITM 150
           PYMAPERINPELNQKGYNVKSDVWSLGITM
Sbjct: 200 PYMAPERINPELNQKGYNVKSDVWSLGITM 229


>gi|21618349 mitogen-activated protein kinase kinase 3 isoform B
           [Homo sapiens]
          Length = 347

 Score =  310 bits (793), Expect = 7e-85
 Identities = 150/150 (100%), Positives = 150/150 (100%)

Query: 1   MDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDKFYRKVLDKNMTIPEDILGE 60
           MDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDKFYRKVLDKNMTIPEDILGE
Sbjct: 109 MDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDKFYRKVLDKNMTIPEDILGE 168

Query: 61  IAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCK 120
           IAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCK
Sbjct: 169 IAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCK 228

Query: 121 PYMAPERINPELNQKGYNVKSDVWSLGITM 150
           PYMAPERINPELNQKGYNVKSDVWSLGITM
Sbjct: 229 PYMAPERINPELNQKGYNVKSDVWSLGITM 258


>gi|239757989 PREDICTED: similar to MAP kinase 3c [Homo sapiens]
          Length = 353

 Score =  307 bits (787), Expect = 3e-84
 Identities = 149/150 (99%), Positives = 149/150 (99%)

Query: 1   MDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDKFYRKVLDKNMTIPEDILGE 60
           MDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDKFYRKVLDKNMTIPEDILGE
Sbjct: 114 MDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDKFYRKVLDKNMTIPEDILGE 173

Query: 61  IAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCK 120
           IAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAK MDAGCK
Sbjct: 174 IAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKMMDAGCK 233

Query: 121 PYMAPERINPELNQKGYNVKSDVWSLGITM 150
           PYMAPERINPELNQKGYNVKSDVWSLGITM
Sbjct: 234 PYMAPERINPELNQKGYNVKSDVWSLGITM 263


>gi|14589900 mitogen-activated protein kinase kinase 6 [Homo
           sapiens]
          Length = 334

 Score =  280 bits (715), Expect = 7e-76
 Identities = 134/150 (89%), Positives = 144/150 (96%)

Query: 1   MDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDKFYRKVLDKNMTIPEDILGE 60
           MDLDI+MRTVDC +TVTFYGALFREGDVWICMELMDTSLDKFY++V+DK  TIPEDILG+
Sbjct: 98  MDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGK 157

Query: 61  IAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCK 120
           IAVSIV+ALEHLHSKLSVIHRDVKPSNVLIN  G VKMCDFGISGYLVDSVAKT+DAGCK
Sbjct: 158 IAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCK 217

Query: 121 PYMAPERINPELNQKGYNVKSDVWSLGITM 150
           PYMAPERINPELNQKGY+VKSD+WSLGITM
Sbjct: 218 PYMAPERINPELNQKGYSVKSDIWSLGITM 247


>gi|4506889 mitogen-activated protein kinase kinase 4 [Homo sapiens]
          Length = 399

 Score =  213 bits (541), Expect = 1e-55
 Identities = 99/156 (63%), Positives = 127/156 (81%), Gaps = 5/156 (3%)

Query: 1   MDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDKFYR---KVLDKNMTIPEDI 57
           MDLD+ MR+ DC Y V FYGALFREGD WICMELM TS DKFY+    VLD    IPE+I
Sbjct: 147 MDLDVVMRSSDCPYIVQFYGALFREGDCWICMELMSTSFDKFYKYVYSVLDD--VIPEEI 204

Query: 58  LGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDA 117
           LG+I ++ V+AL HL   L +IHRD+KPSN+L+++ G++K+CDFGISG LVDS+AKT DA
Sbjct: 205 LGKITLATVKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDA 264

Query: 118 GCKPYMAPERINPELNQKGYNVKSDVWSLGITMQKV 153
           GC+PYMAPERI+P  +++GY+V+SDVWSLGIT+ ++
Sbjct: 265 GCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYEL 300


>gi|21735544 mitogen-activated protein kinase kinase 7 [Homo
           sapiens]
          Length = 419

 Score =  152 bits (385), Expect = 1e-37
 Identities = 77/151 (50%), Positives = 107/151 (70%), Gaps = 4/151 (2%)

Query: 1   MDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDKFYRKVLDKNMTIPEDILGE 60
           MDLD+ +++ DC Y V  +G      DV+I MELM T  +K  +++      IPE ILG+
Sbjct: 165 MDLDVVLKSHDCPYIVQCFGTFITNTDVFIAMELMGTCAEKLKKRMQGP---IPERILGK 221

Query: 61  IAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCK 120
           + V+IV+AL +L  K  VIHRDVKPSN+L+++ G +K+CDFGISG LVDS AKT  AGC 
Sbjct: 222 MTVAIVKALYYLKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCA 281

Query: 121 PYMAPERIN-PELNQKGYNVKSDVWSLGITM 150
            YMAPERI+ P+  +  Y++++DVWSLGI++
Sbjct: 282 AYMAPERIDPPDPTKPDYDIRADVWSLGISL 312


>gi|13489054 mitogen-activated protein kinase kinase 2 [Homo
           sapiens]
          Length = 400

 Score =  132 bits (333), Expect = 1e-31
 Identities = 65/138 (47%), Positives = 98/138 (71%), Gaps = 10/138 (7%)

Query: 14  YTVTFYGALFREGDVWICMELMDT-SLDKFYRKVLDKNMTIPEDILGEIAVSIVRALEHL 72
           Y V FYGA + +G++ ICME MD  SLD+    VL +   IPE+ILG+++++++R L +L
Sbjct: 129 YIVGFYGAFYSDGEISICMEHMDGGSLDQ----VLKEAKRIPEEILGKVSIAVLRGLAYL 184

Query: 73  HSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCKPYMAPERINPEL 132
             K  ++HRDVKPSN+L+N  G +K+CDFG+SG L+DS+A +   G + YMAPER    L
Sbjct: 185 REKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSF-VGTRSYMAPER----L 239

Query: 133 NQKGYNVKSDVWSLGITM 150
               Y+V+SD+WS+G+++
Sbjct: 240 QGTHYSVQSDIWSMGLSL 257


>gi|5579478 mitogen-activated protein kinase kinase 1 [Homo sapiens]
          Length = 393

 Score =  131 bits (329), Expect = 4e-31
 Identities = 64/138 (46%), Positives = 97/138 (70%), Gaps = 10/138 (7%)

Query: 14  YTVTFYGALFREGDVWICMELMDT-SLDKFYRKVLDKNMTIPEDILGEIAVSIVRALEHL 72
           Y V FYGA + +G++ ICME MD  SLD+    VL K   IPE ILG++++++++ L +L
Sbjct: 125 YIVGFYGAFYSDGEISICMEHMDGGSLDQ----VLKKAGRIPEQILGKVSIAVIKGLTYL 180

Query: 73  HSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCKPYMAPERINPEL 132
             K  ++HRDVKPSN+L+N  G +K+CDFG+SG L+DS+A +   G + YM+PER    L
Sbjct: 181 REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSF-VGTRSYMSPER----L 235

Query: 133 NQKGYNVKSDVWSLGITM 150
               Y+V+SD+WS+G+++
Sbjct: 236 QGTHYSVQSDIWSMGLSL 253


>gi|4506101 mitogen-activated protein kinase kinase 5 isoform B
           [Homo sapiens]
          Length = 438

 Score =  127 bits (319), Expect = 6e-30
 Identities = 70/143 (48%), Positives = 91/143 (63%), Gaps = 13/143 (9%)

Query: 11  DCFYTVTFYGALFREGDVWICMELMDTSLDKFYRKVLDKNMTIPEDILGEIAVSIVRALE 70
           D  Y + FYGA F E  + IC E MD      YRK+       PE +LG IAV++V+ L 
Sbjct: 220 DSSYIIGFYGAFFVENRISICTEFMDGGSLDVYRKM-------PEHVLGRIAVAVVKGLT 272

Query: 71  HLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCKPYMAPERINP 130
           +L S L ++HRDVKPSN+L+N  G VK+CDFG+S  LV+S+AKT   G   YMAPERI+ 
Sbjct: 273 YLWS-LKILHRDVKPSNMLVNTRGQVKLCDFGVSTQLVNSIAKTY-VGTNAYMAPERISG 330

Query: 131 ELNQKGYNVKSDVWSLGITMQKV 153
           E     Y + SDVWSLGI+  ++
Sbjct: 331 E----QYGIHSDVWSLGISFMEI 349


>gi|21729895 mitogen-activated protein kinase kinase 5 isoform A
           [Homo sapiens]
          Length = 448

 Score =  126 bits (317), Expect = 1e-29
 Identities = 70/143 (48%), Positives = 91/143 (63%), Gaps = 13/143 (9%)

Query: 11  DCFYTVTFYGALFREGDVWICMELMDTSLDKFYRKVLDKNMTIPEDILGEIAVSIVRALE 70
           D  Y + FYGA F E  + IC E MD      YRK+       PE +LG IAV++V+ L 
Sbjct: 220 DSSYIIGFYGAFFVENRISICTEFMDGGSLDVYRKM-------PEHVLGRIAVAVVKGLT 272

Query: 71  HLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCKPYMAPERINP 130
           +L S L ++HRDVKPSN+L+N  G VK+CDFG+S  LV+S+AKT   G   YMAPERI+ 
Sbjct: 273 YLWS-LKILHRDVKPSNMLVNTRGQVKLCDFGVSTQLVNSIAKTY-VGTNAYMAPERISG 330

Query: 131 ELNQKGYNVKSDVWSLGITMQKV 153
           E     Y + SDVWSLGI+  ++
Sbjct: 331 E----QYGIHSDVWSLGISFMEL 349


>gi|103471999 serine/threonine kinase 3 [Homo sapiens]
          Length = 491

 Score =  103 bits (256), Expect = 1e-22
 Identities = 60/145 (41%), Positives = 85/145 (58%), Gaps = 10/145 (6%)

Query: 7   MRTVDCFYTVTFYGALFREGDVWICMELMDT-SLDKFYRKVLDKNMTIPEDILGEIAVSI 65
           M+  D  Y V +YG+ F+  D+WI ME     S+    R    +N T+ ED +  I  S 
Sbjct: 74  MQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRL---RNKTLIEDEIATILKST 130

Query: 66  VRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDA-GCKPYMA 124
           ++ LE+LH  +  IHRD+K  N+L+N EGH K+ DFG++G L D++AK     G   +MA
Sbjct: 131 LKGLEYLHF-MRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMA 189

Query: 125 PERINPELNQKGYNVKSDVWSLGIT 149
           PE I     + GYN  +D+WSLGIT
Sbjct: 190 PEVI----QEIGYNCVADIWSLGIT 210


>gi|5454096 serine/threonine kinase 4 [Homo sapiens]
          Length = 487

 Score =  102 bits (253), Expect = 3e-22
 Identities = 59/145 (40%), Positives = 85/145 (58%), Gaps = 10/145 (6%)

Query: 7   MRTVDCFYTVTFYGALFREGDVWICMELMDT-SLDKFYRKVLDKNMTIPEDILGEIAVSI 65
           M+  D  + V +YG+ F+  D+WI ME     S+    R    +N T+ ED +  I  S 
Sbjct: 77  MQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRL---RNKTLTEDEIATILQST 133

Query: 66  VRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDA-GCKPYMA 124
           ++ LE+LH  +  IHRD+K  N+L+N EGH K+ DFG++G L D++AK     G   +MA
Sbjct: 134 LKGLEYLHF-MRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMA 192

Query: 125 PERINPELNQKGYNVKSDVWSLGIT 149
           PE I     + GYN  +D+WSLGIT
Sbjct: 193 PEVI----QEIGYNCVADIWSLGIT 213


>gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens]
          Length = 431

 Score = 86.3 bits (212), Expect = 2e-17
 Identities = 51/142 (35%), Positives = 81/142 (57%), Gaps = 14/142 (9%)

Query: 11  DCFYTVTFYGALFREGDVWICMELMD--TSLDKFYRKVLDKNMTIPEDILGEIAVSIVRA 68
           D  Y   +YG+  ++  +WI ME +   ++LD      LD+        +  I   I++ 
Sbjct: 78  DSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLEPGPLDETQ------IATILREILKG 131

Query: 69  LEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDS-VAKTMDAGCKPYMAPER 127
           L++LHS+   IHRD+K +NVL+++ G VK+ DFG++G L D+ + +    G   +MAPE 
Sbjct: 132 LDYLHSEKK-IHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEV 190

Query: 128 INPELNQKGYNVKSDVWSLGIT 149
           I     Q  Y+ K+D+WSLGIT
Sbjct: 191 I----KQSAYDSKADIWSLGIT 208


>gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens]
          Length = 443

 Score = 86.3 bits (212), Expect = 2e-17
 Identities = 51/142 (35%), Positives = 81/142 (57%), Gaps = 14/142 (9%)

Query: 11  DCFYTVTFYGALFREGDVWICMELMD--TSLDKFYRKVLDKNMTIPEDILGEIAVSIVRA 68
           D  Y   +YG+  ++  +WI ME +   ++LD      LD+        +  I   I++ 
Sbjct: 90  DSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLEPGPLDETQ------IATILREILKG 143

Query: 69  LEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDS-VAKTMDAGCKPYMAPER 127
           L++LHS+   IHRD+K +NVL+++ G VK+ DFG++G L D+ + +    G   +MAPE 
Sbjct: 144 LDYLHSEKK-IHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEV 202

Query: 128 INPELNQKGYNVKSDVWSLGIT 149
           I     Q  Y+ K+D+WSLGIT
Sbjct: 203 I----KQSAYDSKADIWSLGIT 220


>gi|21361358 serine/threonine kinase 25 [Homo sapiens]
          Length = 426

 Score = 85.1 bits (209), Expect = 4e-17
 Identities = 51/142 (35%), Positives = 82/142 (57%), Gaps = 14/142 (9%)

Query: 11  DCFYTVTFYGALFREGDVWICMELMD--TSLDKFYRKVLDKNMTIPEDILGEIAVSIVRA 68
           D  Y   ++G+  +   +WI ME +   ++LD      L K   + E  +  I   I++ 
Sbjct: 74  DSPYITRYFGSYLKSTKLWIIMEYLGGGSALD------LLKPGPLEETYIATILREILKG 127

Query: 69  LEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDS-VAKTMDAGCKPYMAPER 127
           L++LHS+   IHRD+K +NVL++++G VK+ DFG++G L D+ + +    G   +MAPE 
Sbjct: 128 LDYLHSERK-IHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEV 186

Query: 128 INPELNQKGYNVKSDVWSLGIT 149
           I     Q  Y+ K+D+WSLGIT
Sbjct: 187 I----KQSAYDFKADIWSLGIT 204


>gi|19424132 NIMA-related kinase 7 [Homo sapiens]
          Length = 302

 Score = 84.7 bits (208), Expect = 5e-17
 Identities = 49/146 (33%), Positives = 78/146 (53%), Gaps = 7/146 (4%)

Query: 16  VTFYGALFREGDVWICMELMDTS-LDKFYRKVLDKNMTIPEDILGEIAVSIVRALEHLHS 74
           + +Y +   + ++ I +EL D   L +  +    +   IPE  + +  V +  ALEH+HS
Sbjct: 95  IKYYASFIEDNELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSALEHMHS 154

Query: 75  KLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVD-SVAKTMDAGCKPYMAPERINPELN 133
           +  V+HRD+KP+NV I   G VK+ D G+  +    + A     G   YM+PERI    +
Sbjct: 155 R-RVMHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERI----H 209

Query: 134 QKGYNVKSDVWSLGITMQKVCCRWRP 159
           + GYN KSD+WSLG  + ++     P
Sbjct: 210 ENGYNFKSDIWSLGCLLYEMAALQSP 235


>gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo
           sapiens]
          Length = 416

 Score = 84.0 bits (206), Expect = 8e-17
 Identities = 50/142 (35%), Positives = 80/142 (56%), Gaps = 14/142 (9%)

Query: 11  DCFYTVTFYGALFREGDVWICMELMD--TSLDKFYRKVLDKNMTIPEDILGEIAVSIVRA 68
           D  Y   +YG+  +   +WI ME +   ++LD       D      E  +  +   I++ 
Sbjct: 78  DSSYVTKYYGSYLKGSKLWIIMEYLGGGSALDLLRAGPFD------EFQIATMLKEILKG 131

Query: 69  LEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDS-VAKTMDAGCKPYMAPER 127
           L++LHS+   IHRD+K +NVL++++G VK+ DFG++G L D+ + +    G   +MAPE 
Sbjct: 132 LDYLHSEKK-IHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEV 190

Query: 128 INPELNQKGYNVKSDVWSLGIT 149
           I     Q  Y+ K+D+WSLGIT
Sbjct: 191 I----QQSAYDSKADIWSLGIT 208


>gi|22035600 mitogen-activated protein kinase kinase kinase kinase 2
           [Homo sapiens]
          Length = 820

 Score = 83.2 bits (204), Expect = 1e-16
 Identities = 54/136 (39%), Positives = 73/136 (53%), Gaps = 8/136 (5%)

Query: 16  VTFYGALFREGDVWICMELMDT-SLDKFYRKVLDKNMTIPEDILGEIAVSIVRALEHLHS 74
           V + G+  R   +WICME     SL + Y         + E  +  +    ++ L HLHS
Sbjct: 74  VAYIGSYLRNDRLWICMEFCGGGSLQEIYHAT----GPLEERQIAYVCREALKGLHHLHS 129

Query: 75  KLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCKPY-MAPERINPELN 133
           +   IHRD+K +N+L+  +G VK+ DFG+SG L  SVAK       PY MAPE    E  
Sbjct: 130 Q-GKIHRDIKGANLLLTLQGDVKLADFGVSGELTASVAKRRSFIGTPYWMAPEVAAVE-R 187

Query: 134 QKGYNVKSDVWSLGIT 149
           + GYN   DVW+LGIT
Sbjct: 188 KGGYNELCDVWALGIT 203


>gi|126362971 serine/threonine kinase 10 [Homo sapiens]
          Length = 968

 Score = 82.8 bits (203), Expect = 2e-16
 Identities = 51/146 (34%), Positives = 79/146 (54%), Gaps = 5/146 (3%)

Query: 7   MRTVDCFYTVTFYGALFREGDVWICMELMDTSLDKFYRKVLDKNMTIPEDILGEIAVSIV 66
           + T D  Y V   GA + +G +WI +E             LD+ +T P+  +  +   ++
Sbjct: 85  LATCDHPYIVKLLGAYYHDGKLWIMIEFCPGGAVDAIMLELDRGLTEPQ--IQVVCRQML 142

Query: 67  RALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCKPY-MAP 125
            AL  LHSK  +IHRD+K  NVL+  EG +++ DFG+S   + ++ K       PY MAP
Sbjct: 143 EALNFLHSK-RIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAP 201

Query: 126 ERINPE-LNQKGYNVKSDVWSLGITM 150
           E +  E +    Y+ K+D+WSLGIT+
Sbjct: 202 EVVMCETMKDTPYDYKADIWSLGITL 227


>gi|32455269 serine/threonine kinase 32C [Homo sapiens]
          Length = 486

 Score = 82.8 bits (203), Expect = 2e-16
 Identities = 48/154 (31%), Positives = 84/154 (54%), Gaps = 5/154 (3%)

Query: 7   MRTVDCFYTVTFYGALFREGDVWICMELMDTSLDKFYRKVLDKNMTIPEDILGEIAVSIV 66
           ++ ++  + V  + +   E D+++ ++L+   L    R  L +N+   ED +      + 
Sbjct: 145 LQEIEHVFLVNLWYSFQDEEDMFMVVDLL---LGGDLRYHLQQNVQFSEDTVRLYICEMA 201

Query: 67  RALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCKPYMAPE 126
            AL++L  +  +IHRDVKP N+L+++ GH  + DF I+  + D    T  AG KPYMAPE
Sbjct: 202 LALDYLRGQ-HIIHRDVKPDNILLDERGHAHLTDFNIATIIKDGERATALAGTKPYMAPE 260

Query: 127 RINPELN-QKGYNVKSDVWSLGITMQKVCCRWRP 159
             +  +N   GY+ + D WS+G+   ++   WRP
Sbjct: 261 IFHSFVNGGTGYSFEVDWWSVGVMAYELLRGWRP 294


>gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Homo
           sapiens]
          Length = 740

 Score = 80.5 bits (197), Expect = 9e-16
 Identities = 51/155 (32%), Positives = 85/155 (54%), Gaps = 13/155 (8%)

Query: 14  YTVTFYGALFREGDVWICMELMDTSLDKFYRKVLDKNMTIPEDILGEIAVSIVRALEHLH 73
           + V  + A   EG +++ ++ +    D F R  L K +   E+ +      +  AL+HLH
Sbjct: 129 FIVKLHYAFQTEGKLYLILDFLRGG-DLFTR--LSKEVMFTEEDVKFYLAELALALDHLH 185

Query: 74  SKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMD-AGCKPYMAPERINPEL 132
           S L +I+RD+KP N+L+++EGH+K+ DFG+S   +D   K     G   YMAPE +    
Sbjct: 186 S-LGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVV---- 240

Query: 133 NQKGYNVKSDVWSLGITMQKVCCRWRPGTLRWGGR 167
           N++G+   +D WS G+ M ++      GTL + G+
Sbjct: 241 NRRGHTQSADWWSFGVLMFEML----TGTLPFQGK 271



 Score = 57.4 bits (137), Expect = 8e-09
 Identities = 41/139 (29%), Positives = 71/139 (51%), Gaps = 17/139 (12%)

Query: 28  VWICMELMDTS--LDKFYRKVLDKNMTIPEDILGEIAVSIVRALEHLHSKLSVIHRDVKP 85
           V++  ELM     LDK  R+         E     +  +I + +E+LH++  V+HRD+KP
Sbjct: 489 VYVVTELMKGGELLDKILRQKF-----FSEREASAVLFTITKTVEYLHAQ-GVVHRDLKP 542

Query: 86  SNVL-INKEGH---VKMCDFGISGYLVDSVAKTMDAGCKPYMAPERINPE-LNQKGYNVK 140
           SN+L +++ G+   +++CDFG +  L       M     P      + PE L ++GY+  
Sbjct: 543 SNILYVDESGNPESIRICDFGFAKQLRAENGLLMT----PCYTANFVAPEVLKRQGYDAA 598

Query: 141 SDVWSLGITMQKVCCRWRP 159
            D+WSLG+ +  +   + P
Sbjct: 599 CDIWSLGVLLYTMLTGYTP 617


>gi|222418622 NIMA-related kinase 6 isoform 1 [Homo sapiens]
          Length = 347

 Score = 80.5 bits (197), Expect = 9e-16
 Identities = 48/149 (32%), Positives = 82/149 (55%), Gaps = 13/149 (8%)

Query: 16  VTFYGALFREGDVWICMELMD----TSLDKFYRKVLDKNMTIPEDILGEIAVSIVRALEH 71
           + +  +   + ++ I +EL D    + + K+++K   +   IPE  + +  V +  A+EH
Sbjct: 140 IKYLDSFIEDNELNIVLELADAGDLSQMIKYFKK---QKRLIPERTVWKYFVQLCSAVEH 196

Query: 72  LHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYL-VDSVAKTMDAGCKPYMAPERINP 130
           +HS+  V+HRD+KP+NV I   G VK+ D G+  +   ++ A     G   YM+PERI  
Sbjct: 197 MHSR-RVMHRDIKPANVFITATGVVKLGDLGLGRFFSSETTAAHSLVGTPYYMSPERI-- 253

Query: 131 ELNQKGYNVKSDVWSLGITMQKVCCRWRP 159
             ++ GYN KSD+WSLG  + ++     P
Sbjct: 254 --HENGYNFKSDIWSLGCLLYEMAALQSP 280


>gi|19923407 NIMA-related kinase 6 isoform 2 [Homo sapiens]
          Length = 313

 Score = 80.5 bits (197), Expect = 9e-16
 Identities = 48/149 (32%), Positives = 82/149 (55%), Gaps = 13/149 (8%)

Query: 16  VTFYGALFREGDVWICMELMD----TSLDKFYRKVLDKNMTIPEDILGEIAVSIVRALEH 71
           + +  +   + ++ I +EL D    + + K+++K   +   IPE  + +  V +  A+EH
Sbjct: 106 IKYLDSFIEDNELNIVLELADAGDLSQMIKYFKK---QKRLIPERTVWKYFVQLCSAVEH 162

Query: 72  LHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYL-VDSVAKTMDAGCKPYMAPERINP 130
           +HS+  V+HRD+KP+NV I   G VK+ D G+  +   ++ A     G   YM+PERI  
Sbjct: 163 MHSR-RVMHRDIKPANVFITATGVVKLGDLGLGRFFSSETTAAHSLVGTPYYMSPERI-- 219

Query: 131 ELNQKGYNVKSDVWSLGITMQKVCCRWRP 159
             ++ GYN KSD+WSLG  + ++     P
Sbjct: 220 --HENGYNFKSDIWSLGCLLYEMAALQSP 246


>gi|134288915 myosin IIIB isoform 1 [Homo sapiens]
          Length = 1314

 Score = 79.7 bits (195), Expect = 1e-15
 Identities = 49/142 (34%), Positives = 77/142 (54%), Gaps = 9/142 (6%)

Query: 16  VTFYGALFRE-----GDVWICMELMDT-SLDKFYRKVLDKNMTIPEDILGEIAVSIVRAL 69
           V FYG  ++      G +W+ +EL +  S+ +  + +L     + E ++  I    +  L
Sbjct: 85  VKFYGMFYKADHCVGGQLWLVLELCNGGSVTELVKGLLRCGQRLDEAMISYILYGALLGL 144

Query: 70  EHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDS-VAKTMDAGCKPYMAPERI 128
           +HLH+   +IHRDVK +N+L+  EG VK+ DFG+S  L  + + +    G   +MAPE I
Sbjct: 145 QHLHNN-RIIHRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRLRRNTSVGTPFWMAPEVI 203

Query: 129 NPELN-QKGYNVKSDVWSLGIT 149
             E      Y+ + DVWSLGIT
Sbjct: 204 ACEQQYDSSYDARCDVWSLGIT 225


>gi|134288892 myosin IIIB isoform 2 [Homo sapiens]
          Length = 1341

 Score = 79.7 bits (195), Expect = 1e-15
 Identities = 49/142 (34%), Positives = 77/142 (54%), Gaps = 9/142 (6%)

Query: 16  VTFYGALFRE-----GDVWICMELMDT-SLDKFYRKVLDKNMTIPEDILGEIAVSIVRAL 69
           V FYG  ++      G +W+ +EL +  S+ +  + +L     + E ++  I    +  L
Sbjct: 85  VKFYGMFYKADHCVGGQLWLVLELCNGGSVTELVKGLLRCGQRLDEAMISYILYGALLGL 144

Query: 70  EHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDS-VAKTMDAGCKPYMAPERI 128
           +HLH+   +IHRDVK +N+L+  EG VK+ DFG+S  L  + + +    G   +MAPE I
Sbjct: 145 QHLHNN-RIIHRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRLRRNTSVGTPFWMAPEVI 203

Query: 129 NPELN-QKGYNVKSDVWSLGIT 149
             E      Y+ + DVWSLGIT
Sbjct: 204 ACEQQYDSSYDARCDVWSLGIT 225


>gi|8923754 serine/threonine kinase 32B [Homo sapiens]
          Length = 414

 Score = 79.3 bits (194), Expect = 2e-15
 Identities = 48/147 (32%), Positives = 80/147 (54%), Gaps = 5/147 (3%)

Query: 14  YTVTFYGALFREGDVWICMELMDTSLDKFYRKVLDKNMTIPEDILGEIAVSIVRALEHLH 73
           + V  + +   E D+++ ++L+   L    R  L +N+   E  +      +  ALE+L 
Sbjct: 82  FLVNLWYSFQDEEDMFMVVDLL---LGGDLRYHLQQNVHFTEGTVKLYICELALALEYLQ 138

Query: 74  SKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCKPYMAPERINPELN 133
            +  +IHRD+KP N+L+++ GHV + DF I+  +  +   +  AG KPYMAPE     ++
Sbjct: 139 -RYHIIHRDIKPDNILLDEHGHVHITDFNIATVVKGAERASSMAGTKPYMAPEVFQVYMD 197

Query: 134 Q-KGYNVKSDVWSLGITMQKVCCRWRP 159
           +  GY+   D WSLGIT  ++   WRP
Sbjct: 198 RGPGYSYPVDWWSLGITAYELLRGWRP 224


>gi|163310763 serine/threonine kinase 32A isoform 1 [Homo sapiens]
          Length = 396

 Score = 79.0 bits (193), Expect = 3e-15
 Identities = 49/150 (32%), Positives = 81/150 (54%), Gaps = 5/150 (3%)

Query: 14  YTVTFYGALFREGDVWICMELMDTSLDKFYRKVLDKNMTIPEDILGEIAVSIVRALEHLH 73
           + V  + +   E D+++ ++L+   L    R  L +N+   E+ +      +V AL++L 
Sbjct: 82  FLVNLWYSFQDEEDMFMVVDLL---LGGDLRYHLQQNVHFKEETVKLFICELVMALDYLQ 138

Query: 74  SKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCKPYMAPERINPELN 133
           ++  +IHRD+KP N+L+++ GHV + DF I+  L      T  AG KPYMAPE  +    
Sbjct: 139 NQ-RIIHRDMKPDNILLDEHGHVHITDFNIAAMLPRETQITTMAGTKPYMAPEMFSSR-K 196

Query: 134 QKGYNVKSDVWSLGITMQKVCCRWRPGTLR 163
             GY+   D WSLG+T  ++    RP  +R
Sbjct: 197 GAGYSFAVDWWSLGVTAYELLRGRRPYHIR 226


>gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1
           isoform b [Homo sapiens]
          Length = 744

 Score = 78.6 bits (192), Expect = 3e-15
 Identities = 50/151 (33%), Positives = 84/151 (55%), Gaps = 10/151 (6%)

Query: 1   MDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDKFYRKVLDKNMTIPEDILGE 60
           M+ DI +  V+  + V  + A   EG +++ ++ +    D F R  L K +   E+ +  
Sbjct: 120 MERDI-LADVNHPFVVKLHYAFQTEGKLYLILDFLRGG-DLFTR--LSKEVMFTEEDVKF 175

Query: 61  IAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMD-AGC 119
               +   L+HLHS L +I+RD+KP N+L+++EGH+K+ DFG+S   +D   K     G 
Sbjct: 176 YLAELALGLDHLHS-LGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGT 234

Query: 120 KPYMAPERINPELNQKGYNVKSDVWSLGITM 150
             YMAPE +    N++G++  +D WS G+ M
Sbjct: 235 VEYMAPEVV----NRQGHSHSADWWSYGVLM 261



 Score = 54.3 bits (129), Expect = 7e-08
 Identities = 34/101 (33%), Positives = 58/101 (57%), Gaps = 10/101 (9%)

Query: 64  SIVRALEHLHSKLSVIHRDVKPSNVL-INKEGH---VKMCDFGISGYLVDSVAKTMDAGC 119
           +I + +E+LHS+  V+HRD+KPSN+L +++ G+   +++CDFG +  L       M    
Sbjct: 527 TIGKTVEYLHSQ-GVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMT--- 582

Query: 120 KPYMAPERINPE-LNQKGYNVKSDVWSLGITMQKVCCRWRP 159
            P      + PE L ++GY+   D+WSLGI +  +   + P
Sbjct: 583 -PCYTANFVAPEVLKRQGYDEGCDIWSLGILLYTMLAGYTP 622


>gi|20149547 ribosomal protein S6 kinase, 90kDa, polypeptide 1
           isoform a [Homo sapiens]
          Length = 735

 Score = 78.6 bits (192), Expect = 3e-15
 Identities = 50/151 (33%), Positives = 84/151 (55%), Gaps = 10/151 (6%)

Query: 1   MDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDKFYRKVLDKNMTIPEDILGE 60
           M+ DI +  V+  + V  + A   EG +++ ++ +    D F R  L K +   E+ +  
Sbjct: 111 MERDI-LADVNHPFVVKLHYAFQTEGKLYLILDFLRGG-DLFTR--LSKEVMFTEEDVKF 166

Query: 61  IAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMD-AGC 119
               +   L+HLHS L +I+RD+KP N+L+++EGH+K+ DFG+S   +D   K     G 
Sbjct: 167 YLAELALGLDHLHS-LGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGT 225

Query: 120 KPYMAPERINPELNQKGYNVKSDVWSLGITM 150
             YMAPE +    N++G++  +D WS G+ M
Sbjct: 226 VEYMAPEVV----NRQGHSHSADWWSYGVLM 252



 Score = 54.3 bits (129), Expect = 7e-08
 Identities = 34/101 (33%), Positives = 58/101 (57%), Gaps = 10/101 (9%)

Query: 64  SIVRALEHLHSKLSVIHRDVKPSNVL-INKEGH---VKMCDFGISGYLVDSVAKTMDAGC 119
           +I + +E+LHS+  V+HRD+KPSN+L +++ G+   +++CDFG +  L       M    
Sbjct: 518 TIGKTVEYLHSQ-GVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMT--- 573

Query: 120 KPYMAPERINPE-LNQKGYNVKSDVWSLGITMQKVCCRWRP 159
            P      + PE L ++GY+   D+WSLGI +  +   + P
Sbjct: 574 -PCYTANFVAPEVLKRQGYDEGCDIWSLGILLYTMLAGYTP 613


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.322    0.139    0.443 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 7,738,813
Number of Sequences: 37866
Number of extensions: 334599
Number of successful extensions: 2220
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 550
Number of HSP's successfully gapped in prelim test: 225
Number of HSP's that attempted gapping in prelim test: 1102
Number of HSP's gapped (non-prelim): 833
length of query: 198
length of database: 18,247,518
effective HSP length: 97
effective length of query: 101
effective length of database: 14,574,516
effective search space: 1472026116
effective search space used: 1472026116
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 59 (27.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.