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Search of human proteins with 117553613
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|117553613 coiled-coil domain containing 151 [Homo sapiens]
(595 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|117553613 coiled-coil domain containing 151 [Homo sapiens] 1159 0.0
gi|89886470 hypothetical protein LOC84960 [Homo sapiens] 120 4e-27
gi|31982906 cingulin-like 1 [Homo sapiens] 81 3e-15
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens] 75 1e-13
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 74 3e-13
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 74 5e-13
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 72 2e-12
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 72 2e-12
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 72 2e-12
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 72 2e-12
gi|114155142 nuclear pore complex-associated protein TPR [Homo s... 72 2e-12
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 72 2e-12
gi|38044112 restin isoform b [Homo sapiens] 71 2e-12
gi|4506751 restin isoform a [Homo sapiens] 71 2e-12
gi|148746195 trichohyalin [Homo sapiens] 71 2e-12
gi|156766068 CDC42 binding protein kinase gamma (DMPK-like) [Hom... 71 3e-12
gi|217272804 hyaluronan-mediated motility receptor isoform d [Ho... 70 7e-12
gi|217272802 hyaluronan-mediated motility receptor isoform a [Ho... 70 7e-12
gi|217416398 hyaluronan-mediated motility receptor isoform c [Ho... 70 7e-12
gi|217416394 hyaluronan-mediated motility receptor isoform b [Ho... 70 7e-12
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H... 69 9e-12
gi|239745127 PREDICTED: similar to Putative golgin subfamily A m... 69 1e-11
gi|64085252 hypothetical protein LOC145508 [Homo sapiens] 69 1e-11
gi|154350226 hypothetical protein LOC79632 isoform 1 [Homo sapiens] 69 1e-11
gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta ... 69 2e-11
gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens] 68 2e-11
gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens] 68 2e-11
gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens] 68 2e-11
gi|32698688 citron [Homo sapiens] 68 2e-11
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens] 68 2e-11
>gi|117553613 coiled-coil domain containing 151 [Homo sapiens]
Length = 595
Score = 1159 bits (2997), Expect = 0.0
Identities = 595/595 (100%), Positives = 595/595 (100%)
Query: 1 MTSPLCRAASANALPPQDQASTPSSRVKGREASGKPSHLRGKGTAQAWTPGRSKGGSFHR 60
MTSPLCRAASANALPPQDQASTPSSRVKGREASGKPSHLRGKGTAQAWTPGRSKGGSFHR
Sbjct: 1 MTSPLCRAASANALPPQDQASTPSSRVKGREASGKPSHLRGKGTAQAWTPGRSKGGSFHR 60
Query: 61 GAGKPSVHSQVAELHKKIQLLEGDRKAFFESSQWNIKKNQETISQLRKETKALELKLLDL 120
GAGKPSVHSQVAELHKKIQLLEGDRKAFFESSQWNIKKNQETISQLRKETKALELKLLDL
Sbjct: 61 GAGKPSVHSQVAELHKKIQLLEGDRKAFFESSQWNIKKNQETISQLRKETKALELKLLDL 120
Query: 121 LKGDEKVVQAVIREWKWEKPYLKNRTGQALEHLDHRLREKVKQQNALRHQVVLRQRRLEE 180
LKGDEKVVQAVIREWKWEKPYLKNRTGQALEHLDHRLREKVKQQNALRHQVVLRQRRLEE
Sbjct: 121 LKGDEKVVQAVIREWKWEKPYLKNRTGQALEHLDHRLREKVKQQNALRHQVVLRQRRLEE 180
Query: 181 LQLQHSLRLLEMAEAQNRHTEVAKTMRNLENRLEKAQMKAQEAEHITSVYLQLKAYLMDE 240
LQLQHSLRLLEMAEAQNRHTEVAKTMRNLENRLEKAQMKAQEAEHITSVYLQLKAYLMDE
Sbjct: 181 LQLQHSLRLLEMAEAQNRHTEVAKTMRNLENRLEKAQMKAQEAEHITSVYLQLKAYLMDE 240
Query: 241 SLNLENRLDSMEAEVVRTKHELEALHVVNQEALNARDIAKNQLQYLEETLVRERKKRERY 300
SLNLENRLDSMEAEVVRTKHELEALHVVNQEALNARDIAKNQLQYLEETLVRERKKRERY
Sbjct: 241 SLNLENRLDSMEAEVVRTKHELEALHVVNQEALNARDIAKNQLQYLEETLVRERKKRERY 300
Query: 301 ISECKKRAEEKKLENERMERKTHREHLLLQSDDTIQDSLHAKEEELRQRWSMYQMEVIFG 360
ISECKKRAEEKKLENERMERKTHREHLLLQSDDTIQDSLHAKEEELRQRWSMYQMEVIFG
Sbjct: 301 ISECKKRAEEKKLENERMERKTHREHLLLQSDDTIQDSLHAKEEELRQRWSMYQMEVIFG 360
Query: 361 KVKDATGTDETHSLVRRFLAQGDTFAQLETLKSENEQTLVRLKQEKQQLQRELEDLKYSG 420
KVKDATGTDETHSLVRRFLAQGDTFAQLETLKSENEQTLVRLKQEKQQLQRELEDLKYSG
Sbjct: 361 KVKDATGTDETHSLVRRFLAQGDTFAQLETLKSENEQTLVRLKQEKQQLQRELEDLKYSG 420
Query: 421 EATLVSQQKLQAEAQERLKKEERRHAEAKDQLERALRAMQVAKDSLEHLASKLIHITVED 480
EATLVSQQKLQAEAQERLKKEERRHAEAKDQLERALRAMQVAKDSLEHLASKLIHITVED
Sbjct: 421 EATLVSQQKLQAEAQERLKKEERRHAEAKDQLERALRAMQVAKDSLEHLASKLIHITVED 480
Query: 481 GRFAGKELDPQADNYVPNLLGLVEEKLLKLQAQLQGHDVQEMLCHIANREFLASLEGRLP 540
GRFAGKELDPQADNYVPNLLGLVEEKLLKLQAQLQGHDVQEMLCHIANREFLASLEGRLP
Sbjct: 481 GRFAGKELDPQADNYVPNLLGLVEEKLLKLQAQLQGHDVQEMLCHIANREFLASLEGRLP 540
Query: 541 EYNTRIALPLATSKDKFFDEESEEEDNEVVTRASLKIRSQKLIESHKKHRRSRRS 595
EYNTRIALPLATSKDKFFDEESEEEDNEVVTRASLKIRSQKLIESHKKHRRSRRS
Sbjct: 541 EYNTRIALPLATSKDKFFDEESEEEDNEVVTRASLKIRSQKLIESHKKHRRSRRS 595
>gi|89886470 hypothetical protein LOC84960 [Homo sapiens]
Length = 534
Score = 120 bits (301), Expect = 4e-27
Identities = 129/545 (23%), Positives = 242/545 (44%), Gaps = 23/545 (4%)
Query: 60 RGAGKPSVHSQVAELHKKIQLLEGDRKAFFESSQWNIKKNQETISQLRKETKALELKLLD 119
R + V Q EL QL E R + + N+ +N+ T++ LR +
Sbjct: 2 RRHSETDVEEQTQELKTITQLQEQCRALQIQGVKENMDQNKATLALLRSNIRRGAQDWAL 61
Query: 120 LLKGDEKVV-QAVIREWKWEKPYLKNRTGQALEHLDHRLREKVKQQNALRHQVVLRQRRL 178
K D+ + +A + + ++ E L + ++V N L H V R ++L
Sbjct: 62 AKKYDQWTISKACGKNLPLRLAHCRSTMEVVREKLRKYVFDRVNMHNLLIHLVRRRGQKL 121
Query: 179 EELQLQ-HSLRLLEMAEAQNRHTEVAKTMRNLENRLEKAQMKAQEAEHITSVYLQLKAYL 237
E +QL+ SLR +A + + +R LEN +EK +K +++I +YL L YL
Sbjct: 122 ESMQLELDSLR--SQPDASKEELRLLQIIRQLENNIEKTMIKIITSQNIHLLYLDLLDYL 179
Query: 238 MDESLNLENRLDSMEAEVVRTKHELEALHVVNQEALNARDIAKNQLQYLEETLVRERKKR 297
LD ++ VV EL + +++Q+A+ D K ++ E + + ER+ R
Sbjct: 180 KTVLAGYPIELDKLQNLVVNYCSELSDMKIMSQDAMMITDEVKRNMRQREASFIEERRAR 239
Query: 298 ERYISECKKRAEEKKLENERMERKTHREHLLLQSDDTIQ--DSLHAKEEELRQRWSMYQM 355
E +++ KK + K+ + K R + L + ++L + +E YQ
Sbjct: 240 ENRLNQQKKLID--KIHTKETSEKYRRGQMDLDFPSNLMSTETLKLRRKETSTAEMEYQS 297
Query: 356 EV--IFGKVKDATGTDETHSLVRRFLAQGDTFAQLETLKSENEQTLVRLKQEKQQLQREL 413
V + KVK A + RFLAQ +T LE + E+ V+LK +QL+ E
Sbjct: 298 GVTAVVEKVKSAVRCSHVWDITSRFLAQRNTEENLELQMEDCEERRVQLKALVKQLELEE 357
Query: 414 EDLKYSGEATLVSQQKLQAEAQERLKKEERRHAEAKDQLERALRAMQVAKDSLEHLASKL 473
LK+ + + +S + ++ + + LK+EE R A + + + + +++L +L
Sbjct: 358 AVLKFRQKPSSISFKSVEKKMTDMLKEEEERLQLAHSNMTKGQELLLTIQMGIDNLYVRL 417
Query: 474 IHITVEDGRFAGKELDPQADNYVPNLLGLVEEKLLKLQAQLQGHDVQEMLCHIANREFLA 533
+ IT+ + +E+ + + L E KL L ++Q E + +
Sbjct: 418 MGITLPATQ---REVVLSNTLDLNSKLAYCEGKLTYLADRVQMVSRTEE----GDTKVRD 470
Query: 534 SLEGR--LPEYNTRIALPLATSKDKFFD--EESEEEDNEVVTRASLKIRSQKLIESHKKH 589
+LE + +YNTRI+ ++ D + + + + V +RA +K ++Q+LIE K
Sbjct: 471 TLESSTLMEKYNTRIS--FENREEDMIDTFQFPDMDHSYVPSRAEIKRQAQRLIEGKLKA 528
Query: 590 RRSRR 594
+ ++
Sbjct: 529 AKKKK 533
>gi|31982906 cingulin-like 1 [Homo sapiens]
Length = 1302
Score = 80.9 bits (198), Expect = 3e-15
Identities = 110/535 (20%), Positives = 232/535 (43%), Gaps = 70/535 (13%)
Query: 90 ESSQWNIKKNQETISQLRKETKALELKLLDLL--------------KGDEKVVQAVIREW 135
E S+ ++KN E + Q++ E + + ++ DL + +++ A+I E
Sbjct: 673 EESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIEEL 732
Query: 136 KWEKPYLKNRTGQALEHLD---HRLREKVKQQNALRHQVVLRQRRLEELQLQHSLRLLEM 192
K L++ E D R RE + AL+ +V + +++L+ Q+ L +
Sbjct: 733 LQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQAL 792
Query: 193 AEAQNRHTEVAKTMRNLENRLEKAQMKAQEAEHITSVYLQLKAYLMDESLNLENRLDSME 252
E+ T+ + + + N E+ Q + +++K L +E+ L+ R + +E
Sbjct: 793 RESVEEATKNVEVLASRSNTSEQDQAGTE---------MRVKL-LQEENEKLQGRSEELE 842
Query: 253 AEVVRTKHELEALHVVNQEALNARDIAKNQLQYLEETLVRERKKRERYIS-----ECKKR 307
V + + ++E L +A + +++ LEE LV RK+ + +S E +
Sbjct: 843 RRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELE 902
Query: 308 AEEKKLENERMERKTHREHLLLQSDDTIQDSLHAKEEELRQRW----SMYQMEVIFGKVK 363
A + L E+K E L +S+ + K E +RW ++ +++ +
Sbjct: 903 AAQGNLSQTTQEQKQLSEKLKEESEQK-EQLRRLKNEMENERWHLGKTIEKLQKEMADIV 961
Query: 364 DATGT---------DETHSLVRRFLAQGDTFAQLETLKSENEQ-TLVRLKQEKQQLQREL 413
+A+ T DE RR LA+ + +TL++E + T ++++ E + ++ EL
Sbjct: 962 EASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEEL 1021
Query: 414 EDLKYSGEATLVSQQKLQAEAQERLKKEERRHAEAKDQLERALRAMQVAKDSL------E 467
D + + + L +Q L+ ++ L+ E + KD R ++ M+ L E
Sbjct: 1022 RDYQRAQDEALTKRQLLEQTLKD-LEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEE 1080
Query: 468 HLASKLIHITVEDGRFAGKELDPQADNYVPNLLGLVEEKLLKLQAQLQGHDVQEMLCHIA 527
S L+ + R ++++ + + + + K+ + Q D++ + H+
Sbjct: 1081 RNNSDLLSERISRSR---EQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIHLE 1137
Query: 528 NREFLASLEGRLPEYNTRIALPLATSKDKFFDEESEEEDNEVVTRASLKIRSQKL 582
+ +S EG + + RI A +D+ ESEE D RA+L++ +++L
Sbjct: 1138 G-SYRSSKEGLVVQMEARI----AELEDRL---ESEERD-----RANLQLSNRRL 1179
Score = 73.6 bits (179), Expect = 5e-13
Identities = 106/471 (22%), Positives = 210/471 (44%), Gaps = 51/471 (10%)
Query: 143 KNRTGQALEHLDHRLREKVKQQNALRHQVVLRQRRLEELQLQHSLRLLEMAEAQNRHTEV 202
K++ + L +L+ +VK Q ++ + + LEEL+ QH+ ++ E + Q R E
Sbjct: 616 KSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQHNEKVEENSTLQQRLEES 675
Query: 203 AKTMRNLENRLEKAQMKAQEAEHITSVY-LQLKAYLMDESLNLENRLDSME-----AEVV 256
+R +N E Q+K + +H T + LQ + M + L+ R + E E++
Sbjct: 676 EGELR--KNLEELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIEELL 733
Query: 257 RTKHELEALHVVNQEALNARDIAKNQLQYLEETLVRERKKRERYISECKKR--AEEKKLE 314
+ K +L+ L + +E + + +L L+ L E ++ + + K++ AE + L
Sbjct: 734 QAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALR 793
Query: 315 NERMERKTHREHLLLQSDDTIQDSLHAKEEELRQRWSMYQMEVIFGKVKDATGTDETHSL 374
E + E L +S+ + QD E+R + + E + G+ ++E
Sbjct: 794 ESVEEATKNVEVLASRSNTSEQDQAGT---EMRVKLLQEENEKLQGR------SEELERR 844
Query: 375 VRRFLAQ-----GDTFAQLETLKS------ENEQTLVRLKQEKQQ---LQRELEDLKYSG 420
V + Q GD ETLK + E+ LV ++E+++ +R LE+ +
Sbjct: 845 VAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAA 904
Query: 421 EATLVSQQKLQAEAQERLKKEERRHAEAKDQLERALRAMQVAK----DSLEHLASKLIHI 476
+ L + Q + E+LK+E +E K+QL R M+ + ++E L ++ I
Sbjct: 905 QGNLSQTTQEQKQLSEKLKEE----SEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADI 960
Query: 477 TVEDGRFAGKELDPQADNYVPNLLGLVEEKLLKLQAQLQGHDVQ---EMLCHIANREFLA 533
VE R + EL Q D Y +L ++Q QL+ ++ L + ++ +
Sbjct: 961 -VEASRTSTLELQNQLDEYKEK----NRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMR 1015
Query: 534 SLEGRLPEYNTRIALPLATSKDKFFDEESEEEDNEVVTRASLKIRSQKLIE 584
+E L +Y A A +K + ++ ++ + E+ ++ LK +L++
Sbjct: 1016 LMEEELRDYQR--AQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVK 1064
Score = 62.8 bits (151), Expect = 9e-10
Identities = 99/440 (22%), Positives = 196/440 (44%), Gaps = 69/440 (15%)
Query: 70 QVAELHKKIQLLEGDRKAFFESSQWNIKKNQETISQLRKETKALELKLLDLLKGDEKVV- 128
+VA+L ++I+ L+GD K +ET+ + E + LE L+ K +++ V
Sbjct: 844 RVAQLQRQIEDLKGDEA-----------KAKETLKKYEGEIRQLEEALVHARKEEKEAVS 892
Query: 129 --QAVIREWKWEKPYLKNRTGQALEHLDHRLREKVKQQNALRHQVVLRQRRLEELQLQHS 186
+A+ E + + L ++T Q + L +L+E+ +Q+ LR + + E L +
Sbjct: 893 ARRALENELEAAQGNL-SQTTQEQKQLSEKLKEESEQKEQLRR--LKNEMENERWHLGKT 949
Query: 187 LRLL--EMAE-AQNRHTEVAKTMRNLE-----NRLEKAQMKAQ--------EAEHITSVY 230
+ L EMA+ + T + L+ NR E A+M+ Q E +T++
Sbjct: 950 IEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMK 1009
Query: 231 LQLKAYLMDESLNLENRLDS--------MEAEVVRTKHELEALHVVNQEALNARDIAKNQ 282
+Q + LM+E L R +E + ++ELEA + + +++
Sbjct: 1010 MQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDK 1069
Query: 283 LQYLEETLVRERKKRERYISECKKRAEEK--KLENERMERKTHREHLLLQSDDTIQDSLH 340
+ LE L ER + +SE R+ E+ +L NE ++ + R+ L + + SL
Sbjct: 1070 VSQLEMELEEERNNSD-LLSERISRSREQMEQLRNELLQERAARQDL-----ECDKISLE 1123
Query: 341 AKEEELRQRWSMYQMEVIFGKVKDATGTDETHSLVRRFLAQGDTFAQLETLKSENEQTLV 400
+ ++L+ R + +E + K+ LV + A+ A+LE E+
Sbjct: 1124 RQNKDLKSR--IIHLEGSYRSSKEG--------LVVQMEAR---IAELEDRLESEERDRA 1170
Query: 401 RLKQEKQQLQRELEDLKYSGEATLVSQQKLQAEAQERLKKEERRHAEAKDQLER------ 454
L+ ++L+R++++L + +S + + RLK +R+ EA+++++R
Sbjct: 1171 NLQLSNRRLERKVKELVMQVDDEHLSLTDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKK 1230
Query: 455 -ALRAMQVAKDSLEHLASKL 473
R ++ D EHL +L
Sbjct: 1231 KLQRELEEQMDMNEHLQGQL 1250
>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
Length = 1684
Score = 75.5 bits (184), Expect = 1e-13
Identities = 132/565 (23%), Positives = 252/565 (44%), Gaps = 92/565 (16%)
Query: 68 HSQVAELHKKIQLLEGDRKAFFESSQWNIKKNQETISQLRKET--KALELKLLDLLKGDE 125
+ QV +L K QL ++ E S+ + +K+ + Q E+ K E K + DE
Sbjct: 747 NEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAKINEEKCNLAFQRDE 806
Query: 126 KVVQAVIREWKWEKPYLKNRTGQALEHLDHRLREKVKQQNALRHQVVLRQRRLEELQLQH 185
KV+ E + E L+ + E L LR+ +++ VL ++ LEE+Q +
Sbjct: 807 KVL-----ELEKEIKCLQEESVVQCEELKSLLRDYEQEK-------VLLRKELEEIQSEK 854
Query: 186 SLRLLEMAEAQNRHTEVAKTMRNLENRLEKAQMKAQEAEHITSVYLQLKAYLMDESLNLE 245
++ E +N + + +NL ++E+ ++E ++ + + + E NL+
Sbjct: 855 EALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTCSKSE----IHNEKEKCFIKEHENLK 910
Query: 246 NRLDSME-----AEVVRTKHELEALHVVNQEALNARDIAKNQLQYLEETLVRERKKRERY 300
L+ E AE++ K L V + L+ + +L+ E L +E K++E
Sbjct: 911 PLLEQKELRDRRAELILLKDSLAKSPSVKNDPLS----SVKELEEKIENLEKECKEKEEK 966
Query: 301 ISECKKRA--EEKKLENERMERKTHREHLLLQSDDTIQDSLHAKEEELRQRWSMYQMEVI 358
I++ K A +K+L++ R E +T +E L+S + +D L A +L Q Y+ ++
Sbjct: 967 INKIKLVAVKAKKELDSSRKETQTVKEE--LESLRSEKDQLSASMRDLIQGAESYKNLLL 1024
Query: 359 FGK-------VKDATGTDETHSLVRRFLAQGDTFAQLETLKSENEQTLVRL--------- 402
+ V+ + H + ++ Q ET+ S+NE L R+
Sbjct: 1025 EYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETINSDNEDLLARIETLQSNAKL 1084
Query: 403 --------KQEKQQLQRELE------DLKYSGEATLVSQQKLQAEAQERLKKEERRHAEA 448
++ K + +ELE + K AT V++ + E Q +L+KE
Sbjct: 1085 LEVQILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNELE---ELQVQLQKE------- 1134
Query: 449 KDQLERALRAMQVAKDSLEHLASKLIHITVEDGRFAGKELDPQADNYVPNLLGLVEEKLL 508
K QL++ ++ +++ K + + L+++ + D KEL+ + N + L +E +
Sbjct: 1135 KKQLQKTMQELELVKKDAQQ--TTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQE--I 1190
Query: 509 KLQAQLQGHDVQEMLCHIANREFLASLEGRLPEY---NTRIALPLATSKDKFFDEESEEE 565
K+Q Q QE L +E + SL+ + +Y NT+I L +K + D + E
Sbjct: 1191 KIQKQ-----KQETL-----QEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQAET 1240
Query: 566 DNEVVTRASLK---IRSQKLIESHK 587
D+ ++ +ASLK SQ+ +E +K
Sbjct: 1241 DH-LILQASLKGELEASQQQVEVYK 1264
Score = 51.2 bits (121), Expect = 3e-06
Identities = 92/447 (20%), Positives = 183/447 (40%), Gaps = 48/447 (10%)
Query: 88 FFESSQWNIKKNQETISQLRKETKALELKLLDLLKGDEKVVQAVIREWKWEKPYLKNRTG 147
F E K N+ ++ ++E + KL L G K + + E LK +
Sbjct: 377 FHEREDLEFKINELLLA--KEEQGCVIEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQ 434
Query: 148 QALEHLDHR-LREKVKQQNALRHQVVLRQRRLEELQLQHSLRLLEMAEAQN----RHTEV 202
+ + L+ L + K++ L ++ + + E LQ + +L + TE+
Sbjct: 435 KEISELNETFLSDSEKEKLTLMFEIQGLKEQCENLQQEKQEAILNYESLREIMEILQTEL 494
Query: 203 AKTMRNLENRLEKAQMKAQEAEHITSVYLQLKAYLMDESLNLE--NRLDS---------- 250
++ + E MK Q+A + + +L+ ++ LE NRL
Sbjct: 495 GESAGKISQEFES--MKQQQASDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQE 552
Query: 251 MEAEVVRTKHELEALHVVNQEALNARDIAKNQLQYLEETLVRERKKRERYISECKKRAEE 310
+ E+ T L+ + V +L+ RD +L+ +L E+ + +I++ K EE
Sbjct: 553 LVPELENTIKNLQEKNGVYLLSLSQRDTMLKELEGKINSLTEEK---DDFINKLKNSHEE 609
Query: 311 KKLENERMERKTHREHLLLQSDDTIQDSLHAKEEELRQRWSMYQMEVIFGKVKDATGTDE 370
+++ ER+ E L+L+ ++ ++ E L Q+ + E+ G + D+
Sbjct: 610 MDNFHKKCERE---ERLILELGKKVEQTIQYNSE-LEQKVN----ELTGGLEETLKEKDQ 661
Query: 371 THSLVRRFLAQGDTFAQLETLKSENEQTLV----RLKQEKQQLQRELEDLKYSGEATLVS 426
+ + + Q ++ + + S ++L +L EK+QL R+LE E ++
Sbjct: 662 NDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILK 721
Query: 427 QQKLQAEAQERLKKEERRHAEAKDQLERALRAMQVAKDSLEHLASKLIHITVEDGRFAGK 486
+ Q E + +L EE +D L + L QV K + ++L E G +
Sbjct: 722 EHITQLEKKLQLMVEE------QDNLNKLLENEQVQK---LFVKTQLYGFLKEMGSEVSE 772
Query: 487 ELDPQADNYVPNLLGLVEEKLLKLQAQ 513
+ + + V N+L V E L K+ +
Sbjct: 773 DSE---EKDVVNVLQAVGESLAKINEE 796
Score = 50.4 bits (119), Expect = 4e-06
Identities = 54/285 (18%), Positives = 119/285 (41%), Gaps = 11/285 (3%)
Query: 66 SVHSQVAELHKKIQLLEGDRKAFFESSQWNIKKNQETISQLRKETKALELKLLDLLKGDE 125
++ ++ L +Q E Q +K +E + ET L L+ LKG+
Sbjct: 1199 TLQEEITSLQSSVQQYEEKNTKI---KQLLVKTKKELADSKQAETDHLILQAS--LKGEL 1253
Query: 126 KVVQAVIREWKWEKPYLKNRTGQALEHLDHRLREKVKQQNALRHQVVLRQRRLEELQLQH 185
+ Q + +K + + + + EHL + + +A + +V Q + +
Sbjct: 1254 EASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEECRAAKAEQ 1313
Query: 186 SLRLLEMAEAQNRHTEVAKTMRNLENRLEKAQMKAQEAEHITSVYLQLKAYLMDESLNLE 245
+ E + R V K +N + + QE EH+ + QLK L D NL+
Sbjct: 1314 ATVTSEFESYKVRVHNVLKQQKNKSMSQAETEGAKQEREHLEMLIDQLKIKLQDSQNNLQ 1373
Query: 246 NRLDSMEAEVVRTKHE--LEALHVVNQEALNARDIAKNQLQYLEETLVRERKKRERYISE 303
++ E + ++++H+ LE + + QE ++ + +L ++ + + + + +S+
Sbjct: 1374 --INVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSENMMMKSEHTQTVSQ 1431
Query: 304 CKKRAEEKKLENERMERKTHREHLLLQSDDTIQDSLHAKEEELRQ 348
++ + L N ++ H + ++ +T+Q L E +L Q
Sbjct: 1432 L--TSQNEVLRNSFRDQVRHLQEEHRKTVETLQQQLSKMEAQLFQ 1474
Score = 49.7 bits (117), Expect = 8e-06
Identities = 82/421 (19%), Positives = 165/421 (39%), Gaps = 57/421 (13%)
Query: 95 NIKKNQETISQLRKETKALELKLLDLLKGDEKVVQAVIREWKWEKPYLKNRTGQALEHLD 154
++K+ +E I L KE K E K+ ++ V + K E + T E L+
Sbjct: 945 SVKELEEKIENLEKECKEKEEKI--------NKIKLVAVKAKKELDSSRKETQTVKEELE 996
Query: 155 HRLREKVKQQNALRHQVVLRQRRLEELQLQHSLRLLEMAEAQNRHTEVAKTMRNLENRLE 214
LR + Q +A ++ + L L++ + ++ + R + +L +L
Sbjct: 997 S-LRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLR 1055
Query: 215 KAQMKAQEAEHITSVYLQLKAYLMDESLNLENRLDSMEAEVVRTKHELEALHVVNQEALN 274
+ ++ + L L + LE ++ ++ ELEA + ++ +
Sbjct: 1056 NSTLQCETINSDNEDLLARIETLQSNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIK 1115
Query: 275 ARDIAKNQLQYLEETLVRERKKRERYISE---CKKRAEEKKLEN------ERMERKTHRE 325
N+L+ L+ L +E+K+ ++ + E KK A++ L N ER+ ++ +++
Sbjct: 1116 EHATTVNELEELQVQLQKEKKQLQKTMQELELVKKDAQQTTLMNMEIADYERLMKELNQK 1175
Query: 326 ---------------HLLLQSDDTIQDSLHAKEEELRQ----RWSMYQMEVIFGKVKDAT 366
+ Q +T+Q+ + + + ++Q + Q+ V K +
Sbjct: 1176 LTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADS 1235
Query: 367 GTDETHSLVRRFLAQGDTFA----------QLETLKSENEQTLVRLKQEKQQLQRELEDL 416
ET L+ + +G+ A QL + SE + LK +Q QR L
Sbjct: 1236 KQAETDHLILQASLKGELEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLS-- 1293
Query: 417 KYSGEATLVSQQKLQAEAQERLKKEE------RRHAEAKDQLERALRAMQV--AKDSLEH 468
Y T + ++ A+A++ E R H K Q +++ + AK EH
Sbjct: 1294 AYQQRVTALQEECRAAKAEQATVTSEFESYKVRVHNVLKQQKNKSMSQAETEGAKQEREH 1353
Query: 469 L 469
L
Sbjct: 1354 L 1354
Score = 42.7 bits (99), Expect = 0.001
Identities = 85/435 (19%), Positives = 187/435 (42%), Gaps = 57/435 (13%)
Query: 70 QVAELHKKIQLLEGDRKAFFESSQWNIKKNQETIS-------QLRKETKALE--LKLLDL 120
Q+ E+ + +++ + +A + IK++ T++ QL+KE K L+ ++ L+L
Sbjct: 1088 QILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNELEELQVQLQKEKKQLQKTMQELEL 1147
Query: 121 LKGDEKVVQAVIREWKWEKPYLKNRTGQALEHLDHRLREKVKQQNALRHQVVLRQRRLEE 180
+K D + + E + +K L+ +L K + L ++ +++++ E
Sbjct: 1148 VKKDAQQTTLMNMEIADYERLMKE--------LNQKLTNKNNKIEDLEQEIKIQKQKQET 1199
Query: 181 LQLQHSLRLLEMAEAQNRHTEVAKTMRNLENRLEKAQMKAQEAEHITSVYLQLKAYLMDE 240
LQ + + + + + ++T++ + + ++ + E A K E +H+ L+A L E
Sbjct: 1200 LQEEITSLQSSVQQYEEKNTKIKQLL--VKTKKELADSKQAETDHLI-----LQASLKGE 1252
Query: 241 SLNLENRLDSME---AEVVRTKHEL-EALHVVNQEALNARDIAKNQLQYLEE-------- 288
+ +++ + AE+ KH++ E L ++ + ++ L+E
Sbjct: 1253 LEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEECRAAKAE 1312
Query: 289 --TLVRERKKRERYISECKKRAEEKKLENERME-RKTHREHLLLQSDDT---IQDS---L 339
T+ E + + + K+ + K + E K REHL + D +QDS L
Sbjct: 1313 QATVTSEFESYKVRVHNVLKQQKNKSMSQAETEGAKQEREHLEMLIDQLKIKLQDSQNNL 1372
Query: 340 HAKEEELRQRWSMYQMEVI-FGKVKDATGTDETHSLVRRFLAQGDTFAQLETLKSENEQT 398
EL+ S + + K+ T + E + Q + +KSE+ QT
Sbjct: 1373 QINVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSENMM----MKSEHTQT 1428
Query: 399 LVRLKQEKQQLQRELED-LKYSGEATLVSQQKLQAEAQERLKKEERRHAEAKDQLERALR 457
+ +L + + L+ D +++ E +K Q++L K E + + K+ E R
Sbjct: 1429 VSQLTSQNEVLRNSFRDQVRHLQE----EHRKTVETLQQQLSKMEAQLFQLKN--EPTTR 1482
Query: 458 AMQVAKDSLEHLASK 472
+ ++ SL++L +
Sbjct: 1483 SPVSSQQSLKNLRER 1497
Score = 41.2 bits (95), Expect = 0.003
Identities = 91/522 (17%), Positives = 215/522 (41%), Gaps = 60/522 (11%)
Query: 66 SVHSQVAELHKKIQLLEGDRKAFFESSQWNIKKNQET-ISQLRKETKALELKLLDLLKGD 124
S AE++K +L E K E+S+ NI+K E + LRK T D
Sbjct: 262 SAKEHEAEINKLNELKENLVKQC-EASEKNIQKKYECELENLRKATSNANQ--------D 312
Query: 125 EKVVQAVIREWKWEKPYLKNRTGQALEHLDHRLREKVKQQNALRHQVVLRQRRLEELQLQ 184
++ +++E +++ + ++HL+ L+E Q + L+ +E+
Sbjct: 313 NQICSILLQE----NTFVEQVVNEKVKHLEDTLKELESQHSILK----------DEVTYM 358
Query: 185 HSLRLLEMAEAQNRHTEVAKTMRNLENRLEKAQMKAQEAEHITSVYLQLKAYLMDESLNL 244
++L+L +AQ+ E +LE ++ + + +E + L
Sbjct: 359 NNLKLKLEMDAQHIKDEFFHEREDLEFKINELLLAKEEQGCVIE--------------KL 404
Query: 245 ENRLDSMEAEVVRTKHELEALHVVNQEALNARDIAKNQLQYLEETLVRERKKRERYISEC 304
++ L + + T + N+E + ++ + ++ L ET + + +K E+
Sbjct: 405 KSELAGLNKQFCYTVEQ------HNREVQSLKEQHQKEISELNETFLSDSEK-EKLTLMF 457
Query: 305 KKRAEEKKLENERMERKTHREHLLLQSDDTIQDSLHAKEEELRQRWSMYQMEVIFGKVKD 364
+ + +++ EN + E++ + + +++++ + + EL + E K +
Sbjct: 458 EIQGLKEQCENLQQEKQE-----AILNYESLREIMEILQTELGESAGKISQEFESMKQQQ 512
Query: 365 ATGTDETHSLVRRFLAQGDTFAQ-LETLKSENEQTLVRLKQEKQQLQRELEDLKYSGEAT 423
A+ E +R + D + + L+ ENE+ L+ ++ +L+ +++L+
Sbjct: 513 ASDVHELQQKLRTAFTEKDALLETVNRLQGENEK-LLSQQELVPELENTIKNLQEKNGVY 571
Query: 424 LVSQQKLQAEAQERLKKEERRHAEAKDQLERALRAMQVAKDSLEHLASKLIHITVEDGRF 483
L+S + +E L+ + E KD L+ D+ + + +E G+
Sbjct: 572 LLSLSQRDTMLKE-LEGKINSLTEEKDDFINKLKNSHEEMDNFHKKCEREERLILELGKK 630
Query: 484 AGK--ELDPQADNYVPNLLGLVEEKLLKLQAQLQGHD--VQEMLCHIANREFLASLEGRL 539
+ + + + + V L G +EE L + Q + + +M ++E L++ L
Sbjct: 631 VEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSL 690
Query: 540 PEYNTRIA---LPLATSKDKFFDEESEEEDNEVVTRASLKIR 578
E N +++ L+ + F ++ + E +T+ K++
Sbjct: 691 YEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQ 732
Score = 32.0 bits (71), Expect = 1.7
Identities = 55/262 (20%), Positives = 110/262 (41%), Gaps = 63/262 (24%)
Query: 307 RAEEKKLENERMERKTHREHLLLQSDDTIQDSLHAKEEELRQRWSMYQMEVIFGKVKDAT 366
+++ + L E + + ++ +L+Q + L + EELR + V + T
Sbjct: 19 KSKLETLPKEDLIKFAKKQMMLIQKAKSRCTELEKEIEELRSK-----------PVTEGT 67
Query: 367 GTDETHSLVRRFLAQGDTFAQLETLKSENEQTLVRLKQEKQQLQRELED-LKYSGEA--- 422
G D +L R A L K+E EQ + LK+E ++++E+ED + G+A
Sbjct: 68 G-DIIKALTERLDA-------LLLEKAETEQQCLSLKKENIKMKQEVEDSVTKMGDAHKE 119
Query: 423 -----------------TLVSQQKLQAEAQERLKKEERRHAEAKDQLERALRAMQVAKDS 465
L++ + +E + L+K+ + +L L+ ++D+
Sbjct: 120 LEQSHINYVKEIENLKNELMAVRSKYSEDKANLQKQLEEAMNTQLELSEQLKFQNNSEDN 179
Query: 466 LEHLASKLIHIT---VEDGRFAGKELDPQAD------------------NYVPNLLGLVE 504
++ L ++ I E + K+LD D +Y N+ L +
Sbjct: 180 VKKLQEEIEKIRPGFEEQILYLQKQLDATTDEKKETVTQLQNIIEANSQHYQKNINSL-Q 238
Query: 505 EKLLKLQAQLQGHDVQEMLCHI 526
E+LL+L+A + +V+E++C I
Sbjct: 239 EELLQLKA-IHQEEVKELMCQI 259
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 74.3 bits (181), Expect = 3e-13
Identities = 128/571 (22%), Positives = 228/571 (39%), Gaps = 134/571 (23%)
Query: 132 IREWKWEKPYLK-------NRTGQALEHLDHRLREKVKQQNAL---------RHQVVLRQ 175
+R W+W + + K R + L+ D L + ++Q + +HQ +L +
Sbjct: 829 LRHWQWWRVFTKVKPLLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEE 888
Query: 176 RRLEELQLQHSLRLLEMAEAQNRHTEVAKTMRNLENRLEKAQMKAQEAEHITSVYLQLKA 235
+ + QLQ L AEA+ +A + LE L + + +E E + K
Sbjct: 889 KNILAEQLQAETELF--AEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKK 946
Query: 236 YLMDESLNLENRLD--------------SMEAEVVRTKHELEALHVVNQEALNARDIAKN 281
+ +LE +LD + EA++ + + E+ L N + + + + ++
Sbjct: 947 KMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMED 1006
Query: 282 QL-----QYLEE-----TLVRERKKRERYISECK---KRAEEKKLENERMERKTHREHLL 328
++ Q EE L + R K+E IS+ + K+ E+ + E E+ +RK E
Sbjct: 1007 RIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTD 1066
Query: 329 LQSDDTIQDSLHAKEEELRQRWSMYQMEVIFGKVKDATGTDETH------SLVRRFLAQ- 381
LQ D I + L A+ +EL+ + + + E+ + A G DET +VR AQ
Sbjct: 1067 LQ--DQIAE-LQAQIDELKLQLAKKEEEL---QGALARGDDETLHKNNALKVVRELQAQI 1120
Query: 382 ---------------------GDTFAQLETLKSENEQTL----------VRLKQEKQQLQ 410
D +LE LK+E E TL + +QE +L+
Sbjct: 1121 AELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELK 1180
Query: 411 RELEDLKYSGEATLVSQQKLQAEAQERLKKEERRHAEAKDQLER--------------AL 456
+ LE+ + EA + ++ A A E L ++ + K LE+ +
Sbjct: 1181 KALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEV 1240
Query: 457 RAMQVAKDSLEHLASKL------IHITVEDGRFAGKELDPQA---DNYVPNLLGLVEEKL 507
+ +Q K EH KL +H V +G EL +A N + N+ L+EE
Sbjct: 1241 KVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAE 1300
Query: 508 LK----------LQAQLQGHDVQEMLCHIANREFLASLEGRLPEYNTRIALPLATSKDKF 557
K L++QLQ D QE+L ++ +L R+ + L K+
Sbjct: 1301 KKGIKFAKDAASLESQLQ--DTQELLQEETRQKL--NLSSRIRQ--------LEEEKNSL 1348
Query: 558 FDEESEEEDNEVVTRASLKIRSQKLIESHKK 588
+++ EEE+ + +L ++ KK
Sbjct: 1349 QEQQEEEEEARKNLEKQVLALQSQLADTKKK 1379
Score = 66.2 bits (160), Expect = 8e-11
Identities = 121/539 (22%), Positives = 218/539 (40%), Gaps = 94/539 (17%)
Query: 64 KPSVHSQVAELHKKIQLLEGDR-KAFFESSQWNIKKNQETISQLRKETKALELKLLDLLK 122
+ + +QV ELH K+ EGDR + ++ + +S L +E + +K
Sbjct: 1254 RKKLDAQVQELHAKVS--EGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAA 1311
Query: 123 GDEKVVQAVIREWKWEKPYLKNRTGQALEHLDHRLREKVKQQNALRHQVVLRQRRLEELQ 182
E +Q + L+ T Q L +L R+R+ +++N+L+ Q + + L+
Sbjct: 1312 SLESQLQDT-------QELLQEETRQKL-NLSSRIRQLEEEKNSLQEQQEEEEEARKNLE 1363
Query: 183 LQHSLRLLEMAEAQNRHTEVAKTMRNLENRLEKAQMKAQEAEHITSVYLQLKAYLMDESL 242
Q ++A+ + + + T+ +LE +K +K EA S L+ KA D+
Sbjct: 1364 KQVLALQSQLADTKKKVDDDLGTIESLEEAKKKL-LKDAEA---LSQRLEEKALAYDKLE 1419
Query: 243 NLENRLDSMEAEVVRTKHELEALHV-VNQEALNARDIAKNQLQYLEETLVRERKKRERYI 301
+NRL + EL+ L V ++ + A ++ K Q ++ ++ L E+ RY
Sbjct: 1420 KTKNRL----------QQELDDLTVDLDHQRQVASNLEKKQKKF-DQLLAEEKSISARYA 1468
Query: 302 SECKKRAEEKKLENERMERKTHREHLLLQSDDTIQDSLHAKEEELRQRWSMY-QMEVIFG 360
E + RAE + E E R ++++L AKEE RQ + ME +
Sbjct: 1469 EE-RDRAEAEAREKETKALSLAR---------ALEEALEAKEEFERQNKQLRADMEDLMS 1518
Query: 361 KVKDATGTDETHSLVRRFLAQGDTFAQLETLKSENEQTLVRLKQEKQQLQREL---EDLK 417
D G +LE K EQ + ++ + ++L+ EL ED K
Sbjct: 1519 SKDDV----------------GKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAK 1562
Query: 418 YSGEATL----------VSQQKLQAEAQERLKKEERRHAEAKDQLERALRAMQVAKDSLE 467
E + + + Q E ++RL ++ R EA+ + ER RA+ VA
Sbjct: 1563 LRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKM 1622
Query: 468 HLASKLIHITVEDGRFAGKELDPQADNYVPNLLGLVEEKLLKLQAQLQGHDVQEMLCHIA 527
+ K + +E A E V ++L KLQAQ++ + + +
Sbjct: 1623 EIDLKDLEAQIEAANKARDE---------------VIKQLRKLQAQMKDYQRELEEARAS 1667
Query: 528 NREFLA----------SLEGRLPEYNTRIALPLATSKDKFFDEESEEEDNEVVTRASLK 576
E A SLE + + +A + + ++E +E +E+ AS K
Sbjct: 1668 RDEIFAQSKESEKKLKSLEAEILQLQEELA--SSERARRHAEQERDELADEITNSASGK 1724
Score = 65.1 bits (157), Expect = 2e-10
Identities = 127/574 (22%), Positives = 258/574 (44%), Gaps = 82/574 (14%)
Query: 64 KPSVHSQVAELHKKIQLLEGDRKAFFESSQWNIKKNQETISQLRKETKALELKLLDLLKG 123
K + +++ ++ ++I LLE F + + + E SQL +E + + K L ++
Sbjct: 973 KVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEE--KAKNLAKIRN 1030
Query: 124 DEKVVQAVIREWKWEKPYLKNRTGQALEHLDHRLREKVKQQNALRHQVVLRQRRLEELQL 183
++V+ + + E+ + +T Q LE +L + L+ Q+ Q +++EL+L
Sbjct: 1031 KQEVMISDLE----ERLKKEEKTRQELEKAKRKLDGETTD---LQDQIAELQAQIDELKL 1083
Query: 184 QHSLRLLEMAEAQNR-------HTEVAKTMRNLENRLEKAQMKAQEAEHITSVYLQLKAY 236
Q + + E+ A R K +R L+ ++ + Q + + + + K
Sbjct: 1084 QLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRD 1143
Query: 237 LMDE----SLNLENRLDSMEA-EVVRTKHELEALHV---VNQEALN----ARDIAKNQLQ 284
L +E LE+ LD+ A + +RTK E E + + +E N +D+ +
Sbjct: 1144 LSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHAT 1203
Query: 285 YLEETLVRERKKRERYISECKKRAEEKKLENERM--------ERKTHREHLLLQSDDTIQ 336
LEE L + ++ +R+ + +K + + +N+ + + K EH + D +Q
Sbjct: 1204 ALEE-LSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQ 1262
Query: 337 DSLHAKEEELRQRWSMYQMEVIFGKVKDATGTDETHSLVRRFLAQGDTFAQ-LETLKSEN 395
+ LHAK E ++E+ K D +L+ +G FA+ +L+S+
Sbjct: 1263 E-LHAKVSE----GDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQL 1317
Query: 396 EQTLVRLKQEKQQLQ------RELEDLKYSGEATLVSQQKLQAEAQERLKKE----ERRH 445
+ T L++E +Q R+LE+ K S L QQ+ + EA++ L+K+ + +
Sbjct: 1318 QDTQELLQEETRQKLNLSSRIRQLEEEKNS----LQEQQEEEEEARKNLEKQVLALQSQL 1373
Query: 446 AEAKDQLERALRAMQVAKDSLEHLASKLIHITVEDGRFAGKELDPQADNYVPNLLGLVEE 505
A+ K +++ L + +SLE KL+ +D + L+ +A L +
Sbjct: 1374 ADTKKKVDDDLGTI----ESLEEAKKKLL----KDAEALSQRLEEKA---------LAYD 1416
Query: 506 KLLKLQAQLQGH--DVQEMLCHIANREFLASLEGRLPEYNTRIALPLATSKDKFFDE--E 561
KL K + +LQ D+ L H R+ ++LE + +++ +A + S ++ +E
Sbjct: 1417 KLEKTKNRLQQELDDLTVDLDH--QRQVASNLEKKQKKFDQLLAEEKSISA-RYAEERDR 1473
Query: 562 SEEEDNEVVTRA-SLKIRSQKLIESHKKHRRSRR 594
+E E E T+A SL ++ +E+ ++ R +
Sbjct: 1474 AEAEAREKETKALSLARALEEALEAKEEFERQNK 1507
Score = 64.3 bits (155), Expect = 3e-10
Identities = 89/402 (22%), Positives = 188/402 (46%), Gaps = 57/402 (14%)
Query: 91 SSQWNIKKNQETISQLRKETKALELKLLDL---LKGDEKVVQAVIREWKWEKPYLKNRTG 147
SS+ ++ KN + +L K +ALE ++ ++ L+ E +QA E L+
Sbjct: 1518 SSKDDVGKN---VHELEKSKRALEQQVEEMRTQLEELEDELQAT------EDAKLRLEVN 1568
Query: 148 -QALEHLDHRLREKVKQQNALRHQVVLRQRRLEELQLQHSLRLLEMAEAQNRHTEVAKTM 206
QA++ R + +QN + +++++Q R E +L+ + +A A + E+ +
Sbjct: 1569 MQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEI--DL 1626
Query: 207 RNLENRLEKAQMKAQEA-EHITSVYLQLKAY-------------LMDESLNLENRLDSME 252
++LE ++E A E + + + Q+K Y + +S E +L S+E
Sbjct: 1627 KDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLE 1686
Query: 253 AEVVRTKHELEALHVVNQEALNARDIAKNQLQYL---EETLVRERKKRERYISECKKRAE 309
AE+++ + EL + + A RD +++ + L+ E+++ E I++ ++ E
Sbjct: 1687 AEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELE 1746
Query: 310 EKKLENERME---RKTHREHLLLQSDDTIQDSLHAKEEELRQRWSMYQMEVIFGKVKDAT 366
E++ E + RKT + L ++ + S K + RQ+ E + K+++
Sbjct: 1747 EEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKE-LKAKLQELE 1805
Query: 367 GTDETHSLVRRFLAQGDTFAQLETLKSENEQTLVRLKQEKQQLQRELEDLKYSGEATLVS 426
G ++ +F A T + LE ++ Q ++QL++E ++ + + +
Sbjct: 1806 GAVKS-----KFKA---TISALEA----------KIGQLEEQLEQEAKERAAANKLVRRT 1847
Query: 427 QQKLQAEAQERLKKEERRHAEA-KDQLERALRAMQVAKDSLE 467
++KL+ + ++ERRHA+ K+Q+E+A M+ K LE
Sbjct: 1848 EKKLKEIFMQ--VEDERRHADQYKEQMEKANARMKQLKRQLE 1887
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 73.6 bits (179), Expect = 5e-13
Identities = 90/460 (19%), Positives = 203/460 (44%), Gaps = 33/460 (7%)
Query: 67 VHSQVAELHKKIQLLEGDRKAFFESSQWNIKKNQET------ISQLRKETKALELKLLDL 120
+H + E K+ +E +++ + + +K + + L KE + L+ K+ +L
Sbjct: 592 LHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNL 651
Query: 121 LKGDEKVVQAVIREWKWEKPYLK-NRTGQALEHLDHRLREKVKQQNALRHQVVLRQRRLE 179
EK+ + E+ K +T + ++L +L K+ + L + + +R +E
Sbjct: 652 KITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVE 711
Query: 180 ELQLQHSLRLLEMAEAQNRHTEVAKTMRNLENRLEKAQMKAQEAEHITSVYLQLKAYLMD 239
L+ ++MA+ Q + E+ L+ LE + ++ E + Y L
Sbjct: 712 SLKCAS----MKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDI---- 763
Query: 240 ESLNLENRLDSMEAEVVRTKHELEALHVVNQEALNARDIAKNQLQYLEETLVRERKKRER 299
E+ L+ L++ ++ + + EL+ L + NQ + K + LE+ L +E K E+
Sbjct: 764 ENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQ-LEKENKSLEQ 822
Query: 300 YISECKKRAEEKKLENERMERKTHREHLLLQSDDTIQDSLHAKEEELRQRWSMYQMEVIF 359
S+ +K ++ + EN+R+ ++ + L+ ++ +L + + L + +Y+ +
Sbjct: 823 ETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCV- 881
Query: 360 GKVKDATGTDETHSLVRRFLAQGDTFAQLETLKSENEQTLVRLKQEKQQLQRELEDLKYS 419
++K+ E LV+R T L + LV K + QQ+ +LE L +
Sbjct: 882 -RLKELE--KENKELVKRATIDIKTLVTLR-------EDLVSEKLKTQQMNNDLEKLTHE 931
Query: 420 GEATLVSQQKLQAEAQERLKKEERRHAEAKDQLERAL-RAMQVAKDSLEHLASKLIHITV 478
E +++++L + Q + R+ + +LE L +++++ ++ + L ++L T
Sbjct: 932 LEKIGLNKERLLHDEQ----STDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTN 987
Query: 479 EDGRFAGKELDPQADNYVPNLLGLVEEKLLKLQAQLQGHD 518
+ + +EL NY EE++++ + G D
Sbjct: 988 YNQQLR-QELKTVKKNYEALKQRQDEERMVQSSPPISGED 1026
Score = 59.3 bits (142), Expect = 1e-08
Identities = 112/561 (19%), Positives = 231/561 (41%), Gaps = 100/561 (17%)
Query: 66 SVHSQVAELHKKIQLLEGDRKAFFESSQWNIKKNQETISQLRKETKALELKLLDLLKGDE 125
S+ V EL + +EG+ + K+NQ +L K+ + LE +++ K
Sbjct: 471 SLTKTVEELRTTVDSVEGNASKILKME----KENQ----RLSKKVEILENEIVQE-KQSL 521
Query: 126 KVVQAVIREWKWEKPYLKNRTGQALEHLDHRLREKVKQQNALRHQVV--LRQR------- 176
+ Q + ++ EK L+ +T + L R + ++Q+N +Q V LRQR
Sbjct: 522 QNCQNLSKDLMKEKAQLE-KTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEA 580
Query: 177 RLEELQLQHSLRLLEMAEAQNRHTEVAKTMRNLENRLEKAQMKAQEAEHITSVYLQLKAY 236
R+++++ ++ + + E ++ +++ R ++ LE + K + AE
Sbjct: 581 RVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEE----------- 629
Query: 237 LMDESLNLENRLDSMEAEVVRTKHELEALHVVNQEALNARDIAKNQLQYLEETLVRERKK 296
L +E +LE + ++ ++ K E + + QE L RE +K
Sbjct: 630 LENELHHLEKENELLQKKITNLKITCEKIEALEQE---------------NSELERENRK 674
Query: 297 RERYISECKK--------RAEEKKLENERMERKTHREHLLLQSDDTIQDSLHAKEEELRQ 348
++ + K E +L+ E +E + + E L S Q L KE E +
Sbjct: 675 LKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEK 734
Query: 349 RWSMYQMEVIFGKVKDAT-------GTDETHSLVRRFLAQGDTFAQLETLKSENEQTLVR 401
+E++ K G D + +++ L + +++ L+SE L
Sbjct: 735 EQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNK--KIQQLESE----LQD 788
Query: 402 LKQEKQQLQRELEDLKYSGEATLVSQQKLQAEAQERLKKEERRHAEAKDQLERALRAMQV 461
L+ E Q LQ+ LE+LK +S ++L E+L+KE + + QLE+ + ++
Sbjct: 789 LEMENQTLQKNLEELK-------ISSKRL-----EQLEKENKSLEQETSQLEKDKKQLEK 836
Query: 462 AKDSLEHLASKLIHITVEDGRFAGKELDPQADNYVPNLLGLVEEKLLKLQ------AQLQ 515
L A ++ T+E+ L+ + + + +G+ +E ++L+ +L
Sbjct: 837 ENKRLRQQA-EIKDTTLEENNVKIGNLEKE-NKTLSKEIGIYKESCVRLKELEKENKELV 894
Query: 516 GHDVQEMLCHIANREFLASLEGRLPEYN------TRIALPLATSKDKFFDEESEEEDN-- 567
++ + RE L S + + + N T + +K++ +E +D
Sbjct: 895 KRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYK 954
Query: 568 ------EVVTRASLKIRSQKL 582
E + SL+I+ +K+
Sbjct: 955 LLESKLESTLKKSLEIKEEKI 975
Score = 53.5 bits (127), Expect = 5e-07
Identities = 70/344 (20%), Positives = 140/344 (40%), Gaps = 50/344 (14%)
Query: 167 LRHQVVLRQRRLEELQLQHSLRLLEMAEAQNRHTEVAKTMRNLENRLEKAQMKAQEA-EH 225
L + L +RL + + +HS ++E++E ++ + + ++ MK E+ +H
Sbjct: 189 LLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGMKRTESRQH 248
Query: 226 ITSVYLQLKAYLMDESLNLENRLDSMEAEVVRTKHELEALHV----VNQEALNARDIAKN 281
++ KA + L L+ +++ K ELE + + + QE +N A++
Sbjct: 249 LSVELADAKAKIR----RLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARS 304
Query: 282 QLQYLEET-LVRERKKR----ERYISECKKRAEEKKLENERMERKTHREHLLLQSDDTIQ 336
Y +E +RE+ R E +S K+R + + R+E +LL++ ++
Sbjct: 305 ARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLE 364
Query: 337 DSLHA-----------KEEELRQRWSMYQMEVIFGKVKDATGTDETHSLVRRFLAQGDTF 385
D L ++E L+ + ++ ME+ + R+
Sbjct: 365 DQLEGTRARSDKLHELEKENLQLKAKLHDMEM-------------ERDMDRK-------- 403
Query: 386 AQLETLKSENEQTLVRLKQ---EKQQLQRELEDLKYSGEATLVSQQKLQAEAQERLKKEE 442
++E L EN + KQ E L ELE + + E + Q+ L E E
Sbjct: 404 -KIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRL 462
Query: 443 RRHAEAKDQLERALRAMQVAKDSLEHLASKLIHITVEDGRFAGK 486
+ L + + ++ DS+E ASK++ + E+ R + K
Sbjct: 463 LKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKK 506
Score = 52.0 bits (123), Expect = 2e-06
Identities = 96/395 (24%), Positives = 168/395 (42%), Gaps = 53/395 (13%)
Query: 96 IKKNQETISQLRKETKALELKLLDLLKGD----EKVVQAVIREWKWEKPYL-----KNRT 146
+KKN E + Q + E + ++ + G+ E+ Q RE K L N T
Sbjct: 999 VKKNYEALKQRQDEERMVQSS--PPISGEDNKWERESQETTRELLKVKDRLIEVERNNAT 1056
Query: 147 GQALEH-LDHRLREKVKQQNALRHQVVLRQRRLEELQLQHSLRLLEMAEAQ--------- 196
QA + L +L++ Q N L+ Q++ QR+ LQ Q++ + A+ Q
Sbjct: 1057 LQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQ 1116
Query: 197 -----NRHTEVAKTMRNLENRLEKAQMKAQEAEHITSVYLQLKAYLMD-ESLNLENRLDS 250
N++ ++ +LEN E +E E + S+Y L + D E L L + +
Sbjct: 1117 STSLMNQNAQLLIQQSSLENENESV---IKEREDLKSLYDSL---IKDHEKLELLHERQA 1170
Query: 251 MEAEVVRTKH--------ELEALHVVNQEALNARDIAKNQLQYLEETLVRERKKRERYIS 302
E E + +KH LE H ++ N K QL+ LE+ L + ++E+ +
Sbjct: 1171 SEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKML---KVEQEKMLL 1227
Query: 303 ECKKR----AEEKKLENERMERKTHREHLLLQSDDTIQ-DSLHAKEEELRQRWSMYQMEV 357
E K AE KKL E +R H LL+ + +Q D + K + ++E
Sbjct: 1228 ENKNHETVAAEYKKLCGEN-DRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEA 1286
Query: 358 IFGKVKDATGTDETHSLVRRFLAQGDTFAQLE-TLKSENEQTLVRLKQEKQQLQRELEDL 416
F K+K+ + S + Q + +QL+ L+ EN L +++ Q + LE
Sbjct: 1287 EFSKLKEQYQQLDITS--TKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQN 1344
Query: 417 KYSGEATLVSQQKLQAEAQERLKKEERRHAEAKDQ 451
S + V Q++ + E +++E+ + DQ
Sbjct: 1345 MESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQ 1379
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 71.6 bits (174), Expect = 2e-12
Identities = 129/565 (22%), Positives = 226/565 (40%), Gaps = 122/565 (21%)
Query: 132 IREWKWEKPYLK-------NRTGQALEHLDHRLRE-KVKQQNA--------LRHQVVLRQ 175
+R W+W + + K R + ++ + L++ K +QQ A +H + +
Sbjct: 829 LRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEE 888
Query: 176 RRLEELQLQHSLRLLEMAEAQNRHTEVAKTMRNLENRLEKAQMKAQEAEHITSVYLQLKA 235
+ L + QLQ L AEA+ +A + LE L + + + +E E +
Sbjct: 889 KNLLQEQLQAETELY--AEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERK 946
Query: 236 YLMDESLNLENRLD--------------SMEAEVVRTKHELEALHVVNQEALNARDIAKN 281
+ + L+LE +L+ + EA++ + + E+ + N + R + +
Sbjct: 947 KMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEE 1006
Query: 282 QLQYLEETLVRE----------RKKRERYISECK---KRAEEKKLENERMERKT------ 322
++ L L E + K E ISE + K+ E+ + E E+++RK
Sbjct: 1007 RISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASD 1066
Query: 323 -HREHLLLQSDDT-IQDSLHAKEEELRQRWSMYQMEVI-----FGKVKDATG--TDETHS 373
H + LQ+ ++ L KEEEL+ + E+ K+++ G +D
Sbjct: 1067 FHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQED 1126
Query: 374 LVRRFLAQG-------DTFAQLETLKSENEQTL----------VRLKQEKQQLQRELEDL 416
L A+ D +LE LK+E E TL + +QE L++ L++
Sbjct: 1127 LDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEE 1186
Query: 417 KYSGEATLVSQQKLQAEAQERLKKEERRHAEAKDQLER--------------ALRAMQVA 462
S EA + ++ A+A E L ++ + AK L++ LR + A
Sbjct: 1187 TRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQA 1246
Query: 463 KDSLEHLASKL------IHITVEDGRFAGKELDPQA---DNYVPNLLGLVEE------KL 507
K +EH KL + DG A EL+ + N V ++ G++ E KL
Sbjct: 1247 KQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKL 1306
Query: 508 LK----LQAQLQGHDVQEMLCHIANREFLASLEGRLPEYNTRIALPLATSKDKFFDEESE 563
K L +QLQ D QE+L ++ S + R E S DEE E
Sbjct: 1307 AKDVASLSSQLQ--DTQELLQEETRQKLNVSTKLRQLEEE-------RNSLQDQLDEEME 1357
Query: 564 EEDNEVVTRASLKIRSQKLIESHKK 588
+ N ++L I +L +S KK
Sbjct: 1358 AKQNLERHISTLNI---QLSDSKKK 1379
Score = 69.7 bits (169), Expect = 7e-12
Identities = 98/457 (21%), Positives = 203/457 (44%), Gaps = 60/457 (13%)
Query: 64 KPSVHSQVAELHKKIQLLEGDR-KAFFESSQWNIKKNQETISQLRKETKALELKLLDLLK 122
K + +QV EL K +G+R +A ++ E+++ + E + +KL
Sbjct: 1254 KKKLEAQVQELQSKCS--DGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLA---- 1307
Query: 123 GDEKVVQAVIREWKWEKPYLKNRTGQALEHLDHRLREKVKQQNALRHQVVLRQRRLEELQ 182
K V ++ + + + L+ T Q L ++ +LR+ +++N+L+ Q+ + L+
Sbjct: 1308 ---KDVASLSSQLQDTQELLQEETRQKL-NVSTKLRQLEEERNSLQDQLDEEMEAKQNLE 1363
Query: 183 LQHSLRLLEMAEAQNRHTEVAKTMRNLENRLEKAQMKAQEAEHITSVYLQLKAYLMDESL 242
S +++++++ + + A T+ LE ++ Q +E E++T Y + KA D+
Sbjct: 1364 RHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQ---KEIENLTQQYEE-KAAAYDKLE 1419
Query: 243 NLENRLDSMEAEVVRTKHELEALHVVNQEALNARDIAKNQLQYLEETLVRERKKRERYIS 302
+NRL + EL+ L V + N R + N L ++++K ++ ++
Sbjct: 1420 KTKNRL----------QQELDDLVV---DLDNQRQLVSN--------LEKKQRKFDQLLA 1458
Query: 303 ECKKRAEEKKLENERMERKTH-REHLLLQSDDTIQDSLHAKEE-ELRQRWSMYQMEVIFG 360
E K + + E +R E + +E L ++++L AKEE E + +ME +
Sbjct: 1459 EEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVS 1518
Query: 361 KVKDATGTDETHSLVRRFLAQGDTFAQLETLKSENEQTLVRLKQEKQQLQRELEDLKYSG 420
D G +LE K E + +K + ++L+ EL+ + +
Sbjct: 1519 SKDDV----------------GKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAK 1562
Query: 421 EATLVSQQKLQAEAQERLKKEERRHAEAKDQLERALRAMQVAKDSLEHLASKLIHITVED 480
V+ Q L+ + + L+ + ++ E + QL+R L + LE +
Sbjct: 1563 LRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYET---ELEDERKQRALAAAAK 1619
Query: 481 GRFAG--KELDPQADNYVPNLLGLVEEKLLKLQAQLQ 515
+ G K+L+ QAD+ + +++ L KLQAQ++
Sbjct: 1620 KKLEGDLKDLELQADSAIKGREEAIKQ-LRKLQAQMK 1655
Score = 53.5 bits (127), Expect = 5e-07
Identities = 87/392 (22%), Positives = 156/392 (39%), Gaps = 37/392 (9%)
Query: 74 LHKKIQLLEGDRKAFFESSQWNIKKNQETISQLRKETKALELKLLDLLKGDEKVVQAVIR 133
L +Q L+G F Q ++N+E QL+++ E +L D K ++ + A +
Sbjct: 1565 LEVNMQALKGQ---FERDLQARDEQNEEKRRQLQRQLHEYETELEDERK--QRALAAAAK 1619
Query: 134 EWKWEKPYLKNRTGQALEHLDHRLREKVKQQNALRHQVVLRQRRLEELQLQHSLRLLEMA 193
+ K E LK+ QA + R E +KQ L+ Q+ QR LE+ +
Sbjct: 1620 K-KLEGD-LKDLELQADSAIKGR-EEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAK 1676
Query: 194 EAQNRHTEVAKTMRNLENRLEKAQM--------KAQEAEHITSVYLQLKAYLMDESLNLE 245
E + + + + L+ L A+ K + AE + S L + L DE LE
Sbjct: 1677 ENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASS-LSGRNALQDEKRRLE 1735
Query: 246 NRLDSMEAEVVRTKHELEALHVVNQEALNARDIAKNQLQYLEETLVRERKKRERYISECK 305
R+ +E E+ + +EA+ ++ A Q + L L ER + K
Sbjct: 1736 ARIAQLEEELEEEQGNMEAMSDRVRK-------ATQQAEQLSNELATERSTAQ------K 1782
Query: 306 KRAEEKKLENERMERKTHREHLLLQSDDTIQDSLHAKEEELRQRWSMYQMEVIFGKVKDA 365
+ ++LE + E ++ + + ++ A E ++ Q + E +
Sbjct: 1783 NESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATK 1842
Query: 366 TGTDETHSLVRRFLAQGDTFAQLETLKSENEQTLVRLKQEKQQLQRELEDLKYSGEATLV 425
+ + L L D E K + E+ R+K QL+R+LE+ + +
Sbjct: 1843 SLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVK----QLKRQLEEAEEESQRINA 1898
Query: 426 SQQKLQAEAQERLKKEERRHAEA---KDQLER 454
+++KLQ E E + E E K +L R
Sbjct: 1899 NRRKLQRELDEATESNEAMGREVNALKSKLRR 1930
Score = 50.8 bits (120), Expect = 3e-06
Identities = 99/459 (21%), Positives = 191/459 (41%), Gaps = 66/459 (14%)
Query: 66 SVHSQVAELHKKIQ-------LLEGDRKAF---FESSQWNIKKNQETISQLRKETKALEL 115
+++ Q+++ KK+Q LE +K F E+ ++ +L K L+
Sbjct: 1368 TLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQ 1427
Query: 116 KLLDLLKGDEKVVQAVIREWKWEKPY---------LKNRTGQALEHLDHRLREKVKQQNA 166
+L DL+ + Q V K ++ + + ++ + + REK + +
Sbjct: 1428 ELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALS 1487
Query: 167 LRHQVVLRQRRLEELQLQHSLRLLEMAE--------AQNRHTEVAKTMRNLENRLEKAQM 218
L + EEL+ + + EM + +N H E+ K+ R LE ++E+ +
Sbjct: 1488 LARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVH-ELEKSKRALETQMEEMKT 1546
Query: 219 KAQEAEHITSVYLQLKAYLMDESLNLENRLDSMEAEVVRTKHELEALHVVNQEALNARDI 278
+ +E E +L+A D L LE + +++ + R +L+A N+E R
Sbjct: 1547 QLEELED------ELQA-TEDAKLRLEVNMQALKGQFER---DLQARDEQNEEK---RRQ 1593
Query: 279 AKNQLQYLEETLVRERKKRERYISECKKRAEEKKLENERMERKTHREHLLLQSDDTIQDS 338
+ QL E L ERK+R A +KKLE + + L LQ+D I+
Sbjct: 1594 LQRQLHEYETELEDERKQR------ALAAAAKKKLEGDLKD-------LELQADSAIK-- 1638
Query: 339 LHAKEEELRQ-RWSMYQMEVIFGKVKDATGT-DETHSLVRRFLAQGDTFA----QLETLK 392
+EE ++Q R QM+ +++DA + DE + + + + QL+
Sbjct: 1639 --GREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDL 1696
Query: 393 SENEQTLVRLKQEKQQLQRELEDLKYSGEATLVSQQKLQAEAQERLKKEERRHAEAKDQL 452
+ E+ + EK++L EL A +++L+A + ++ E +
Sbjct: 1697 AAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMS 1756
Query: 453 ERALRAMQVAKDSLEHLASKLIHITVEDGRFAGKELDPQ 491
+R +A Q A+ LA++ T + A ++L+ Q
Sbjct: 1757 DRVRKATQQAEQLSNELATE--RSTAQKNESARQQLERQ 1793
Score = 50.4 bits (119), Expect = 4e-06
Identities = 87/425 (20%), Positives = 185/425 (43%), Gaps = 42/425 (9%)
Query: 73 ELHKKIQLLEGDRKAFFESSQWNIKKNQETISQLRKETKALELKL---LDLLKGD-EKVV 128
++ K + LE ++A E+ +K E + + T+ +L+L + LKG E+ +
Sbjct: 1522 DVGKNVHELEKSKRAL-ETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDL 1580
Query: 129 QAVIREWKWEKPYLKNRTGQALEHLDHRLREKVKQQNALRHQVVLRQRRLEELQLQHSLR 188
QA + + ++ L+ + L + L ++ KQ+ + L++L+LQ
Sbjct: 1581 QARDEQNEEKRRQLQRQ----LHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSA 1636
Query: 189 LLEMAEAQNRHTEVAKTMRNLENRLEKAQMKAQEAEHITSVYLQLKAYLMDESLNLENRL 248
+ EA + ++ M++ + LE A+ E T+ + KA ++ L ++ +
Sbjct: 1637 IKGREEAIKQLRKLQAQMKDFQRELEDARASRDEI-FATAKENEKKAKSLEADL-MQLQE 1694
Query: 249 DSMEAEVVRTKHELEALHVVNQEA--LNARDIAKNQLQYLEETLVR---ERKKRERYISE 303
D AE R + +LE + + A L+ R+ +++ + LE + + E ++ + +
Sbjct: 1695 DLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEA 1754
Query: 304 CKKRAEEKKLENERMERKTHREHLLLQSDDTIQDSLHAKEEELRQRWSMYQMEVIFGKVK 363
R + + E++ + E Q +++ + L + +ELR + +++ME G VK
Sbjct: 1755 MSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSK--LHEME---GAVK 1809
Query: 364 DATGTDETHSLVRRFLAQGDTFAQLETLKSENEQTLVRLKQEKQQLQRELEDLKYSGEAT 423
+ T + + +AQ + Q+E E + LKQ+ ++L+ L L+ E
Sbjct: 1810 SKFKS--TIAALEAKIAQLEE--QVEQEAREKQAATKSLKQKDKKLKEIL--LQVEDERK 1863
Query: 424 LVSQQKLQAE---------------AQERLKKEERRHAEAKDQLERALRAMQVAKDSLEH 468
+ Q K QAE A+E ++ + + +L+ A + + +
Sbjct: 1864 MAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNA 1923
Query: 469 LASKL 473
L SKL
Sbjct: 1924 LKSKL 1928
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 71.6 bits (174), Expect = 2e-12
Identities = 129/565 (22%), Positives = 226/565 (40%), Gaps = 122/565 (21%)
Query: 132 IREWKWEKPYLK-------NRTGQALEHLDHRLRE-KVKQQNA--------LRHQVVLRQ 175
+R W+W + + K R + ++ + L++ K +QQ A +H + +
Sbjct: 836 LRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEE 895
Query: 176 RRLEELQLQHSLRLLEMAEAQNRHTEVAKTMRNLENRLEKAQMKAQEAEHITSVYLQLKA 235
+ L + QLQ L AEA+ +A + LE L + + + +E E +
Sbjct: 896 KNLLQEQLQAETELY--AEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERK 953
Query: 236 YLMDESLNLENRLD--------------SMEAEVVRTKHELEALHVVNQEALNARDIAKN 281
+ + L+LE +L+ + EA++ + + E+ + N + R + +
Sbjct: 954 KMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEE 1013
Query: 282 QLQYLEETLVRE----------RKKRERYISECK---KRAEEKKLENERMERKT------ 322
++ L L E + K E ISE + K+ E+ + E E+++RK
Sbjct: 1014 RISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASD 1073
Query: 323 -HREHLLLQSDDT-IQDSLHAKEEELRQRWSMYQMEVI-----FGKVKDATG--TDETHS 373
H + LQ+ ++ L KEEEL+ + E+ K+++ G +D
Sbjct: 1074 FHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQED 1133
Query: 374 LVRRFLAQG-------DTFAQLETLKSENEQTL----------VRLKQEKQQLQRELEDL 416
L A+ D +LE LK+E E TL + +QE L++ L++
Sbjct: 1134 LDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEE 1193
Query: 417 KYSGEATLVSQQKLQAEAQERLKKEERRHAEAKDQLER--------------ALRAMQVA 462
S EA + ++ A+A E L ++ + AK L++ LR + A
Sbjct: 1194 TRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQA 1253
Query: 463 KDSLEHLASKL------IHITVEDGRFAGKELDPQA---DNYVPNLLGLVEE------KL 507
K +EH KL + DG A EL+ + N V ++ G++ E KL
Sbjct: 1254 KQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKL 1313
Query: 508 LK----LQAQLQGHDVQEMLCHIANREFLASLEGRLPEYNTRIALPLATSKDKFFDEESE 563
K L +QLQ D QE+L ++ S + R E S DEE E
Sbjct: 1314 AKDVASLSSQLQ--DTQELLQEETRQKLNVSTKLRQLEEE-------RNSLQDQLDEEME 1364
Query: 564 EEDNEVVTRASLKIRSQKLIESHKK 588
+ N ++L I +L +S KK
Sbjct: 1365 AKQNLERHISTLNI---QLSDSKKK 1386
Score = 69.7 bits (169), Expect = 7e-12
Identities = 98/457 (21%), Positives = 203/457 (44%), Gaps = 60/457 (13%)
Query: 64 KPSVHSQVAELHKKIQLLEGDR-KAFFESSQWNIKKNQETISQLRKETKALELKLLDLLK 122
K + +QV EL K +G+R +A ++ E+++ + E + +KL
Sbjct: 1261 KKKLEAQVQELQSKCS--DGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLA---- 1314
Query: 123 GDEKVVQAVIREWKWEKPYLKNRTGQALEHLDHRLREKVKQQNALRHQVVLRQRRLEELQ 182
K V ++ + + + L+ T Q L ++ +LR+ +++N+L+ Q+ + L+
Sbjct: 1315 ---KDVASLSSQLQDTQELLQEETRQKL-NVSTKLRQLEEERNSLQDQLDEEMEAKQNLE 1370
Query: 183 LQHSLRLLEMAEAQNRHTEVAKTMRNLENRLEKAQMKAQEAEHITSVYLQLKAYLMDESL 242
S +++++++ + + A T+ LE ++ Q +E E++T Y + KA D+
Sbjct: 1371 RHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQ---KEIENLTQQYEE-KAAAYDKLE 1426
Query: 243 NLENRLDSMEAEVVRTKHELEALHVVNQEALNARDIAKNQLQYLEETLVRERKKRERYIS 302
+NRL + EL+ L V + N R + N L ++++K ++ ++
Sbjct: 1427 KTKNRL----------QQELDDLVV---DLDNQRQLVSN--------LEKKQRKFDQLLA 1465
Query: 303 ECKKRAEEKKLENERMERKTH-REHLLLQSDDTIQDSLHAKEE-ELRQRWSMYQMEVIFG 360
E K + + E +R E + +E L ++++L AKEE E + +ME +
Sbjct: 1466 EEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVS 1525
Query: 361 KVKDATGTDETHSLVRRFLAQGDTFAQLETLKSENEQTLVRLKQEKQQLQRELEDLKYSG 420
D G +LE K E + +K + ++L+ EL+ + +
Sbjct: 1526 SKDDV----------------GKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAK 1569
Query: 421 EATLVSQQKLQAEAQERLKKEERRHAEAKDQLERALRAMQVAKDSLEHLASKLIHITVED 480
V+ Q L+ + + L+ + ++ E + QL+R L + LE +
Sbjct: 1570 LRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYET---ELEDERKQRALAAAAK 1626
Query: 481 GRFAG--KELDPQADNYVPNLLGLVEEKLLKLQAQLQ 515
+ G K+L+ QAD+ + +++ L KLQAQ++
Sbjct: 1627 KKLEGDLKDLELQADSAIKGREEAIKQ-LRKLQAQMK 1662
Score = 53.5 bits (127), Expect = 5e-07
Identities = 87/392 (22%), Positives = 156/392 (39%), Gaps = 37/392 (9%)
Query: 74 LHKKIQLLEGDRKAFFESSQWNIKKNQETISQLRKETKALELKLLDLLKGDEKVVQAVIR 133
L +Q L+G F Q ++N+E QL+++ E +L D K ++ + A +
Sbjct: 1572 LEVNMQALKGQ---FERDLQARDEQNEEKRRQLQRQLHEYETELEDERK--QRALAAAAK 1626
Query: 134 EWKWEKPYLKNRTGQALEHLDHRLREKVKQQNALRHQVVLRQRRLEELQLQHSLRLLEMA 193
+ K E LK+ QA + R E +KQ L+ Q+ QR LE+ +
Sbjct: 1627 K-KLEGD-LKDLELQADSAIKGR-EEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAK 1683
Query: 194 EAQNRHTEVAKTMRNLENRLEKAQM--------KAQEAEHITSVYLQLKAYLMDESLNLE 245
E + + + + L+ L A+ K + AE + S L + L DE LE
Sbjct: 1684 ENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASS-LSGRNALQDEKRRLE 1742
Query: 246 NRLDSMEAEVVRTKHELEALHVVNQEALNARDIAKNQLQYLEETLVRERKKRERYISECK 305
R+ +E E+ + +EA+ ++ A Q + L L ER + K
Sbjct: 1743 ARIAQLEEELEEEQGNMEAMSDRVRK-------ATQQAEQLSNELATERSTAQ------K 1789
Query: 306 KRAEEKKLENERMERKTHREHLLLQSDDTIQDSLHAKEEELRQRWSMYQMEVIFGKVKDA 365
+ ++LE + E ++ + + ++ A E ++ Q + E +
Sbjct: 1790 NESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATK 1849
Query: 366 TGTDETHSLVRRFLAQGDTFAQLETLKSENEQTLVRLKQEKQQLQRELEDLKYSGEATLV 425
+ + L L D E K + E+ R+K QL+R+LE+ + +
Sbjct: 1850 SLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVK----QLKRQLEEAEEESQRINA 1905
Query: 426 SQQKLQAEAQERLKKEERRHAEA---KDQLER 454
+++KLQ E E + E E K +L R
Sbjct: 1906 NRRKLQRELDEATESNEAMGREVNALKSKLRR 1937
Score = 50.8 bits (120), Expect = 3e-06
Identities = 99/459 (21%), Positives = 191/459 (41%), Gaps = 66/459 (14%)
Query: 66 SVHSQVAELHKKIQ-------LLEGDRKAF---FESSQWNIKKNQETISQLRKETKALEL 115
+++ Q+++ KK+Q LE +K F E+ ++ +L K L+
Sbjct: 1375 TLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQ 1434
Query: 116 KLLDLLKGDEKVVQAVIREWKWEKPY---------LKNRTGQALEHLDHRLREKVKQQNA 166
+L DL+ + Q V K ++ + + ++ + + REK + +
Sbjct: 1435 ELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALS 1494
Query: 167 LRHQVVLRQRRLEELQLQHSLRLLEMAE--------AQNRHTEVAKTMRNLENRLEKAQM 218
L + EEL+ + + EM + +N H E+ K+ R LE ++E+ +
Sbjct: 1495 LARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVH-ELEKSKRALETQMEEMKT 1553
Query: 219 KAQEAEHITSVYLQLKAYLMDESLNLENRLDSMEAEVVRTKHELEALHVVNQEALNARDI 278
+ +E E +L+A D L LE + +++ + R +L+A N+E R
Sbjct: 1554 QLEELED------ELQA-TEDAKLRLEVNMQALKGQFER---DLQARDEQNEEK---RRQ 1600
Query: 279 AKNQLQYLEETLVRERKKRERYISECKKRAEEKKLENERMERKTHREHLLLQSDDTIQDS 338
+ QL E L ERK+R A +KKLE + + L LQ+D I+
Sbjct: 1601 LQRQLHEYETELEDERKQR------ALAAAAKKKLEGDLKD-------LELQADSAIK-- 1645
Query: 339 LHAKEEELRQ-RWSMYQMEVIFGKVKDATGT-DETHSLVRRFLAQGDTFA----QLETLK 392
+EE ++Q R QM+ +++DA + DE + + + + QL+
Sbjct: 1646 --GREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDL 1703
Query: 393 SENEQTLVRLKQEKQQLQRELEDLKYSGEATLVSQQKLQAEAQERLKKEERRHAEAKDQL 452
+ E+ + EK++L EL A +++L+A + ++ E +
Sbjct: 1704 AAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMS 1763
Query: 453 ERALRAMQVAKDSLEHLASKLIHITVEDGRFAGKELDPQ 491
+R +A Q A+ LA++ T + A ++L+ Q
Sbjct: 1764 DRVRKATQQAEQLSNELATE--RSTAQKNESARQQLERQ 1800
Score = 50.4 bits (119), Expect = 4e-06
Identities = 87/425 (20%), Positives = 185/425 (43%), Gaps = 42/425 (9%)
Query: 73 ELHKKIQLLEGDRKAFFESSQWNIKKNQETISQLRKETKALELKL---LDLLKGD-EKVV 128
++ K + LE ++A E+ +K E + + T+ +L+L + LKG E+ +
Sbjct: 1529 DVGKNVHELEKSKRAL-ETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDL 1587
Query: 129 QAVIREWKWEKPYLKNRTGQALEHLDHRLREKVKQQNALRHQVVLRQRRLEELQLQHSLR 188
QA + + ++ L+ + L + L ++ KQ+ + L++L+LQ
Sbjct: 1588 QARDEQNEEKRRQLQRQ----LHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSA 1643
Query: 189 LLEMAEAQNRHTEVAKTMRNLENRLEKAQMKAQEAEHITSVYLQLKAYLMDESLNLENRL 248
+ EA + ++ M++ + LE A+ E T+ + KA ++ L ++ +
Sbjct: 1644 IKGREEAIKQLRKLQAQMKDFQRELEDARASRDEI-FATAKENEKKAKSLEADL-MQLQE 1701
Query: 249 DSMEAEVVRTKHELEALHVVNQEA--LNARDIAKNQLQYLEETLVR---ERKKRERYISE 303
D AE R + +LE + + A L+ R+ +++ + LE + + E ++ + +
Sbjct: 1702 DLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEA 1761
Query: 304 CKKRAEEKKLENERMERKTHREHLLLQSDDTIQDSLHAKEEELRQRWSMYQMEVIFGKVK 363
R + + E++ + E Q +++ + L + +ELR + +++ME G VK
Sbjct: 1762 MSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSK--LHEME---GAVK 1816
Query: 364 DATGTDETHSLVRRFLAQGDTFAQLETLKSENEQTLVRLKQEKQQLQRELEDLKYSGEAT 423
+ T + + +AQ + Q+E E + LKQ+ ++L+ L L+ E
Sbjct: 1817 SKFKS--TIAALEAKIAQLEE--QVEQEAREKQAATKSLKQKDKKLKEIL--LQVEDERK 1870
Query: 424 LVSQQKLQAE---------------AQERLKKEERRHAEAKDQLERALRAMQVAKDSLEH 468
+ Q K QAE A+E ++ + + +L+ A + + +
Sbjct: 1871 MAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNA 1930
Query: 469 LASKL 473
L SKL
Sbjct: 1931 LKSKL 1935
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 71.6 bits (174), Expect = 2e-12
Identities = 129/565 (22%), Positives = 226/565 (40%), Gaps = 122/565 (21%)
Query: 132 IREWKWEKPYLK-------NRTGQALEHLDHRLRE-KVKQQNA--------LRHQVVLRQ 175
+R W+W + + K R + ++ + L++ K +QQ A +H + +
Sbjct: 836 LRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEE 895
Query: 176 RRLEELQLQHSLRLLEMAEAQNRHTEVAKTMRNLENRLEKAQMKAQEAEHITSVYLQLKA 235
+ L + QLQ L AEA+ +A + LE L + + + +E E +
Sbjct: 896 KNLLQEQLQAETELY--AEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERK 953
Query: 236 YLMDESLNLENRLD--------------SMEAEVVRTKHELEALHVVNQEALNARDIAKN 281
+ + L+LE +L+ + EA++ + + E+ + N + R + +
Sbjct: 954 KMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEE 1013
Query: 282 QLQYLEETLVRE----------RKKRERYISECK---KRAEEKKLENERMERKT------ 322
++ L L E + K E ISE + K+ E+ + E E+++RK
Sbjct: 1014 RISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASD 1073
Query: 323 -HREHLLLQSDDT-IQDSLHAKEEELRQRWSMYQMEVI-----FGKVKDATG--TDETHS 373
H + LQ+ ++ L KEEEL+ + E+ K+++ G +D
Sbjct: 1074 FHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQED 1133
Query: 374 LVRRFLAQG-------DTFAQLETLKSENEQTL----------VRLKQEKQQLQRELEDL 416
L A+ D +LE LK+E E TL + +QE L++ L++
Sbjct: 1134 LDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEE 1193
Query: 417 KYSGEATLVSQQKLQAEAQERLKKEERRHAEAKDQLER--------------ALRAMQVA 462
S EA + ++ A+A E L ++ + AK L++ LR + A
Sbjct: 1194 TRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQA 1253
Query: 463 KDSLEHLASKL------IHITVEDGRFAGKELDPQA---DNYVPNLLGLVEE------KL 507
K +EH KL + DG A EL+ + N V ++ G++ E KL
Sbjct: 1254 KQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKL 1313
Query: 508 LK----LQAQLQGHDVQEMLCHIANREFLASLEGRLPEYNTRIALPLATSKDKFFDEESE 563
K L +QLQ D QE+L ++ S + R E S DEE E
Sbjct: 1314 AKDVASLSSQLQ--DTQELLQEETRQKLNVSTKLRQLEEE-------RNSLQDQLDEEME 1364
Query: 564 EEDNEVVTRASLKIRSQKLIESHKK 588
+ N ++L I +L +S KK
Sbjct: 1365 AKQNLERHISTLNI---QLSDSKKK 1386
Score = 69.7 bits (169), Expect = 7e-12
Identities = 98/457 (21%), Positives = 203/457 (44%), Gaps = 60/457 (13%)
Query: 64 KPSVHSQVAELHKKIQLLEGDR-KAFFESSQWNIKKNQETISQLRKETKALELKLLDLLK 122
K + +QV EL K +G+R +A ++ E+++ + E + +KL
Sbjct: 1261 KKKLEAQVQELQSKCS--DGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLA---- 1314
Query: 123 GDEKVVQAVIREWKWEKPYLKNRTGQALEHLDHRLREKVKQQNALRHQVVLRQRRLEELQ 182
K V ++ + + + L+ T Q L ++ +LR+ +++N+L+ Q+ + L+
Sbjct: 1315 ---KDVASLSSQLQDTQELLQEETRQKL-NVSTKLRQLEEERNSLQDQLDEEMEAKQNLE 1370
Query: 183 LQHSLRLLEMAEAQNRHTEVAKTMRNLENRLEKAQMKAQEAEHITSVYLQLKAYLMDESL 242
S +++++++ + + A T+ LE ++ Q +E E++T Y + KA D+
Sbjct: 1371 RHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQ---KEIENLTQQYEE-KAAAYDKLE 1426
Query: 243 NLENRLDSMEAEVVRTKHELEALHVVNQEALNARDIAKNQLQYLEETLVRERKKRERYIS 302
+NRL + EL+ L V + N R + N L ++++K ++ ++
Sbjct: 1427 KTKNRL----------QQELDDLVV---DLDNQRQLVSN--------LEKKQRKFDQLLA 1465
Query: 303 ECKKRAEEKKLENERMERKTH-REHLLLQSDDTIQDSLHAKEE-ELRQRWSMYQMEVIFG 360
E K + + E +R E + +E L ++++L AKEE E + +ME +
Sbjct: 1466 EEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVS 1525
Query: 361 KVKDATGTDETHSLVRRFLAQGDTFAQLETLKSENEQTLVRLKQEKQQLQRELEDLKYSG 420
D G +LE K E + +K + ++L+ EL+ + +
Sbjct: 1526 SKDDV----------------GKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAK 1569
Query: 421 EATLVSQQKLQAEAQERLKKEERRHAEAKDQLERALRAMQVAKDSLEHLASKLIHITVED 480
V+ Q L+ + + L+ + ++ E + QL+R L + LE +
Sbjct: 1570 LRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYET---ELEDERKQRALAAAAK 1626
Query: 481 GRFAG--KELDPQADNYVPNLLGLVEEKLLKLQAQLQ 515
+ G K+L+ QAD+ + +++ L KLQAQ++
Sbjct: 1627 KKLEGDLKDLELQADSAIKGREEAIKQ-LRKLQAQMK 1662
Score = 53.1 bits (126), Expect = 7e-07
Identities = 83/377 (22%), Positives = 151/377 (40%), Gaps = 34/377 (9%)
Query: 74 LHKKIQLLEGDRKAFFESSQWNIKKNQETISQLRKETKALELKLLDLLKGDEKVVQAVIR 133
L +Q L+G F Q ++N+E QL+++ E +L D K ++ + A +
Sbjct: 1572 LEVNMQALKGQ---FERDLQARDEQNEEKRRQLQRQLHEYETELEDERK--QRALAAAAK 1626
Query: 134 EWKWEKPYLKNRTGQALEHLDHRLREKVKQQNALRHQVVLRQRRLEELQLQHSLRLLEMA 193
+ K E LK+ QA + R E +KQ L+ Q+ QR LE+ +
Sbjct: 1627 K-KLEGD-LKDLELQADSAIKGR-EEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAK 1683
Query: 194 EAQNRHTEVAKTMRNLENRLEKAQM--------KAQEAEHITSVYLQLKAYLMDESLNLE 245
E + + + + L+ L A+ K + AE + S L + L DE LE
Sbjct: 1684 ENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASS-LSGRNALQDEKRRLE 1742
Query: 246 NRLDSMEAEVVRTKHELEALHVVNQEALNARDIAKNQLQYLEETLVRERKKRERYISECK 305
R+ +E E+ + +EA+ ++ A Q + L L ER + K
Sbjct: 1743 ARIAQLEEELEEEQGNMEAMSDRVRK-------ATQQAEQLSNELATERSTAQ------K 1789
Query: 306 KRAEEKKLENERMERKTHREHLLLQSDDTIQDSLHAKEEELRQRWSMYQMEVIFGKVKDA 365
+ ++LE + E ++ + + ++ A E ++ Q + E +
Sbjct: 1790 NESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATK 1849
Query: 366 TGTDETHSLVRRFLAQGDTFAQLETLKSENEQTLVRLKQEKQQLQRELEDLKYSGEATLV 425
+ + L L D E K + E+ R+K QL+R+LE+ + +
Sbjct: 1850 SLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVK----QLKRQLEEAEEESQRINA 1905
Query: 426 SQQKLQAEAQERLKKEE 442
+++KLQ E E + E
Sbjct: 1906 NRRKLQRELDEATESNE 1922
Score = 50.8 bits (120), Expect = 3e-06
Identities = 99/459 (21%), Positives = 191/459 (41%), Gaps = 66/459 (14%)
Query: 66 SVHSQVAELHKKIQ-------LLEGDRKAF---FESSQWNIKKNQETISQLRKETKALEL 115
+++ Q+++ KK+Q LE +K F E+ ++ +L K L+
Sbjct: 1375 TLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQ 1434
Query: 116 KLLDLLKGDEKVVQAVIREWKWEKPY---------LKNRTGQALEHLDHRLREKVKQQNA 166
+L DL+ + Q V K ++ + + ++ + + REK + +
Sbjct: 1435 ELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALS 1494
Query: 167 LRHQVVLRQRRLEELQLQHSLRLLEMAE--------AQNRHTEVAKTMRNLENRLEKAQM 218
L + EEL+ + + EM + +N H E+ K+ R LE ++E+ +
Sbjct: 1495 LARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVH-ELEKSKRALETQMEEMKT 1553
Query: 219 KAQEAEHITSVYLQLKAYLMDESLNLENRLDSMEAEVVRTKHELEALHVVNQEALNARDI 278
+ +E E +L+A D L LE + +++ + R +L+A N+E R
Sbjct: 1554 QLEELED------ELQA-TEDAKLRLEVNMQALKGQFER---DLQARDEQNEEK---RRQ 1600
Query: 279 AKNQLQYLEETLVRERKKRERYISECKKRAEEKKLENERMERKTHREHLLLQSDDTIQDS 338
+ QL E L ERK+R A +KKLE + + L LQ+D I+
Sbjct: 1601 LQRQLHEYETELEDERKQR------ALAAAAKKKLEGDLKD-------LELQADSAIK-- 1645
Query: 339 LHAKEEELRQ-RWSMYQMEVIFGKVKDATGT-DETHSLVRRFLAQGDTFA----QLETLK 392
+EE ++Q R QM+ +++DA + DE + + + + QL+
Sbjct: 1646 --GREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDL 1703
Query: 393 SENEQTLVRLKQEKQQLQRELEDLKYSGEATLVSQQKLQAEAQERLKKEERRHAEAKDQL 452
+ E+ + EK++L EL A +++L+A + ++ E +
Sbjct: 1704 AAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMS 1763
Query: 453 ERALRAMQVAKDSLEHLASKLIHITVEDGRFAGKELDPQ 491
+R +A Q A+ LA++ T + A ++L+ Q
Sbjct: 1764 DRVRKATQQAEQLSNELATE--RSTAQKNESARQQLERQ 1800
Score = 50.4 bits (119), Expect = 4e-06
Identities = 87/425 (20%), Positives = 185/425 (43%), Gaps = 42/425 (9%)
Query: 73 ELHKKIQLLEGDRKAFFESSQWNIKKNQETISQLRKETKALELKL---LDLLKGD-EKVV 128
++ K + LE ++A E+ +K E + + T+ +L+L + LKG E+ +
Sbjct: 1529 DVGKNVHELEKSKRAL-ETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDL 1587
Query: 129 QAVIREWKWEKPYLKNRTGQALEHLDHRLREKVKQQNALRHQVVLRQRRLEELQLQHSLR 188
QA + + ++ L+ + L + L ++ KQ+ + L++L+LQ
Sbjct: 1588 QARDEQNEEKRRQLQRQ----LHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSA 1643
Query: 189 LLEMAEAQNRHTEVAKTMRNLENRLEKAQMKAQEAEHITSVYLQLKAYLMDESLNLENRL 248
+ EA + ++ M++ + LE A+ E T+ + KA ++ L ++ +
Sbjct: 1644 IKGREEAIKQLRKLQAQMKDFQRELEDARASRDEI-FATAKENEKKAKSLEADL-MQLQE 1701
Query: 249 DSMEAEVVRTKHELEALHVVNQEA--LNARDIAKNQLQYLEETLVR---ERKKRERYISE 303
D AE R + +LE + + A L+ R+ +++ + LE + + E ++ + +
Sbjct: 1702 DLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEA 1761
Query: 304 CKKRAEEKKLENERMERKTHREHLLLQSDDTIQDSLHAKEEELRQRWSMYQMEVIFGKVK 363
R + + E++ + E Q +++ + L + +ELR + +++ME G VK
Sbjct: 1762 MSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSK--LHEME---GAVK 1816
Query: 364 DATGTDETHSLVRRFLAQGDTFAQLETLKSENEQTLVRLKQEKQQLQRELEDLKYSGEAT 423
+ T + + +AQ + Q+E E + LKQ+ ++L+ L L+ E
Sbjct: 1817 SKFKS--TIAALEAKIAQLEE--QVEQEAREKQAATKSLKQKDKKLKEIL--LQVEDERK 1870
Query: 424 LVSQQKLQAE---------------AQERLKKEERRHAEAKDQLERALRAMQVAKDSLEH 468
+ Q K QAE A+E ++ + + +L+ A + + +
Sbjct: 1871 MAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNA 1930
Query: 469 LASKL 473
L SKL
Sbjct: 1931 LKSKL 1935
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 71.6 bits (174), Expect = 2e-12
Identities = 129/565 (22%), Positives = 226/565 (40%), Gaps = 122/565 (21%)
Query: 132 IREWKWEKPYLK-------NRTGQALEHLDHRLRE-KVKQQNA--------LRHQVVLRQ 175
+R W+W + + K R + ++ + L++ K +QQ A +H + +
Sbjct: 829 LRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEE 888
Query: 176 RRLEELQLQHSLRLLEMAEAQNRHTEVAKTMRNLENRLEKAQMKAQEAEHITSVYLQLKA 235
+ L + QLQ L AEA+ +A + LE L + + + +E E +
Sbjct: 889 KNLLQEQLQAETELY--AEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERK 946
Query: 236 YLMDESLNLENRLD--------------SMEAEVVRTKHELEALHVVNQEALNARDIAKN 281
+ + L+LE +L+ + EA++ + + E+ + N + R + +
Sbjct: 947 KMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEE 1006
Query: 282 QLQYLEETLVRE----------RKKRERYISECK---KRAEEKKLENERMERKT------ 322
++ L L E + K E ISE + K+ E+ + E E+++RK
Sbjct: 1007 RISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASD 1066
Query: 323 -HREHLLLQSDDT-IQDSLHAKEEELRQRWSMYQMEVI-----FGKVKDATG--TDETHS 373
H + LQ+ ++ L KEEEL+ + E+ K+++ G +D
Sbjct: 1067 FHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQED 1126
Query: 374 LVRRFLAQG-------DTFAQLETLKSENEQTL----------VRLKQEKQQLQRELEDL 416
L A+ D +LE LK+E E TL + +QE L++ L++
Sbjct: 1127 LDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEE 1186
Query: 417 KYSGEATLVSQQKLQAEAQERLKKEERRHAEAKDQLER--------------ALRAMQVA 462
S EA + ++ A+A E L ++ + AK L++ LR + A
Sbjct: 1187 TRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQA 1246
Query: 463 KDSLEHLASKL------IHITVEDGRFAGKELDPQA---DNYVPNLLGLVEE------KL 507
K +EH KL + DG A EL+ + N V ++ G++ E KL
Sbjct: 1247 KQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKL 1306
Query: 508 LK----LQAQLQGHDVQEMLCHIANREFLASLEGRLPEYNTRIALPLATSKDKFFDEESE 563
K L +QLQ D QE+L ++ S + R E S DEE E
Sbjct: 1307 AKDVASLSSQLQ--DTQELLQEETRQKLNVSTKLRQLEEE-------RNSLQDQLDEEME 1357
Query: 564 EEDNEVVTRASLKIRSQKLIESHKK 588
+ N ++L I +L +S KK
Sbjct: 1358 AKQNLERHISTLNI---QLSDSKKK 1379
Score = 69.7 bits (169), Expect = 7e-12
Identities = 98/457 (21%), Positives = 203/457 (44%), Gaps = 60/457 (13%)
Query: 64 KPSVHSQVAELHKKIQLLEGDR-KAFFESSQWNIKKNQETISQLRKETKALELKLLDLLK 122
K + +QV EL K +G+R +A ++ E+++ + E + +KL
Sbjct: 1254 KKKLEAQVQELQSKCS--DGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLA---- 1307
Query: 123 GDEKVVQAVIREWKWEKPYLKNRTGQALEHLDHRLREKVKQQNALRHQVVLRQRRLEELQ 182
K V ++ + + + L+ T Q L ++ +LR+ +++N+L+ Q+ + L+
Sbjct: 1308 ---KDVASLSSQLQDTQELLQEETRQKL-NVSTKLRQLEEERNSLQDQLDEEMEAKQNLE 1363
Query: 183 LQHSLRLLEMAEAQNRHTEVAKTMRNLENRLEKAQMKAQEAEHITSVYLQLKAYLMDESL 242
S +++++++ + + A T+ LE ++ Q +E E++T Y + KA D+
Sbjct: 1364 RHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQ---KEIENLTQQYEE-KAAAYDKLE 1419
Query: 243 NLENRLDSMEAEVVRTKHELEALHVVNQEALNARDIAKNQLQYLEETLVRERKKRERYIS 302
+NRL + EL+ L V + N R + N L ++++K ++ ++
Sbjct: 1420 KTKNRL----------QQELDDLVV---DLDNQRQLVSN--------LEKKQRKFDQLLA 1458
Query: 303 ECKKRAEEKKLENERMERKTH-REHLLLQSDDTIQDSLHAKEE-ELRQRWSMYQMEVIFG 360
E K + + E +R E + +E L ++++L AKEE E + +ME +
Sbjct: 1459 EEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVS 1518
Query: 361 KVKDATGTDETHSLVRRFLAQGDTFAQLETLKSENEQTLVRLKQEKQQLQRELEDLKYSG 420
D G +LE K E + +K + ++L+ EL+ + +
Sbjct: 1519 SKDDV----------------GKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAK 1562
Query: 421 EATLVSQQKLQAEAQERLKKEERRHAEAKDQLERALRAMQVAKDSLEHLASKLIHITVED 480
V+ Q L+ + + L+ + ++ E + QL+R L + LE +
Sbjct: 1563 LRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYET---ELEDERKQRALAAAAK 1619
Query: 481 GRFAG--KELDPQADNYVPNLLGLVEEKLLKLQAQLQ 515
+ G K+L+ QAD+ + +++ L KLQAQ++
Sbjct: 1620 KKLEGDLKDLELQADSAIKGREEAIKQ-LRKLQAQMK 1655
Score = 53.1 bits (126), Expect = 7e-07
Identities = 83/377 (22%), Positives = 151/377 (40%), Gaps = 34/377 (9%)
Query: 74 LHKKIQLLEGDRKAFFESSQWNIKKNQETISQLRKETKALELKLLDLLKGDEKVVQAVIR 133
L +Q L+G F Q ++N+E QL+++ E +L D K ++ + A +
Sbjct: 1565 LEVNMQALKGQ---FERDLQARDEQNEEKRRQLQRQLHEYETELEDERK--QRALAAAAK 1619
Query: 134 EWKWEKPYLKNRTGQALEHLDHRLREKVKQQNALRHQVVLRQRRLEELQLQHSLRLLEMA 193
+ K E LK+ QA + R E +KQ L+ Q+ QR LE+ +
Sbjct: 1620 K-KLEGD-LKDLELQADSAIKGR-EEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAK 1676
Query: 194 EAQNRHTEVAKTMRNLENRLEKAQM--------KAQEAEHITSVYLQLKAYLMDESLNLE 245
E + + + + L+ L A+ K + AE + S L + L DE LE
Sbjct: 1677 ENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASS-LSGRNALQDEKRRLE 1735
Query: 246 NRLDSMEAEVVRTKHELEALHVVNQEALNARDIAKNQLQYLEETLVRERKKRERYISECK 305
R+ +E E+ + +EA+ ++ A Q + L L ER + K
Sbjct: 1736 ARIAQLEEELEEEQGNMEAMSDRVRK-------ATQQAEQLSNELATERSTAQ------K 1782
Query: 306 KRAEEKKLENERMERKTHREHLLLQSDDTIQDSLHAKEEELRQRWSMYQMEVIFGKVKDA 365
+ ++LE + E ++ + + ++ A E ++ Q + E +
Sbjct: 1783 NESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATK 1842
Query: 366 TGTDETHSLVRRFLAQGDTFAQLETLKSENEQTLVRLKQEKQQLQRELEDLKYSGEATLV 425
+ + L L D E K + E+ R+K QL+R+LE+ + +
Sbjct: 1843 SLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVK----QLKRQLEEAEEESQRINA 1898
Query: 426 SQQKLQAEAQERLKKEE 442
+++KLQ E E + E
Sbjct: 1899 NRRKLQRELDEATESNE 1915
Score = 50.8 bits (120), Expect = 3e-06
Identities = 99/459 (21%), Positives = 191/459 (41%), Gaps = 66/459 (14%)
Query: 66 SVHSQVAELHKKIQ-------LLEGDRKAF---FESSQWNIKKNQETISQLRKETKALEL 115
+++ Q+++ KK+Q LE +K F E+ ++ +L K L+
Sbjct: 1368 TLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQ 1427
Query: 116 KLLDLLKGDEKVVQAVIREWKWEKPY---------LKNRTGQALEHLDHRLREKVKQQNA 166
+L DL+ + Q V K ++ + + ++ + + REK + +
Sbjct: 1428 ELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALS 1487
Query: 167 LRHQVVLRQRRLEELQLQHSLRLLEMAE--------AQNRHTEVAKTMRNLENRLEKAQM 218
L + EEL+ + + EM + +N H E+ K+ R LE ++E+ +
Sbjct: 1488 LARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVH-ELEKSKRALETQMEEMKT 1546
Query: 219 KAQEAEHITSVYLQLKAYLMDESLNLENRLDSMEAEVVRTKHELEALHVVNQEALNARDI 278
+ +E E +L+A D L LE + +++ + R +L+A N+E R
Sbjct: 1547 QLEELED------ELQA-TEDAKLRLEVNMQALKGQFER---DLQARDEQNEEK---RRQ 1593
Query: 279 AKNQLQYLEETLVRERKKRERYISECKKRAEEKKLENERMERKTHREHLLLQSDDTIQDS 338
+ QL E L ERK+R A +KKLE + + L LQ+D I+
Sbjct: 1594 LQRQLHEYETELEDERKQR------ALAAAAKKKLEGDLKD-------LELQADSAIK-- 1638
Query: 339 LHAKEEELRQ-RWSMYQMEVIFGKVKDATGT-DETHSLVRRFLAQGDTFA----QLETLK 392
+EE ++Q R QM+ +++DA + DE + + + + QL+
Sbjct: 1639 --GREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDL 1696
Query: 393 SENEQTLVRLKQEKQQLQRELEDLKYSGEATLVSQQKLQAEAQERLKKEERRHAEAKDQL 452
+ E+ + EK++L EL A +++L+A + ++ E +
Sbjct: 1697 AAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMS 1756
Query: 453 ERALRAMQVAKDSLEHLASKLIHITVEDGRFAGKELDPQ 491
+R +A Q A+ LA++ T + A ++L+ Q
Sbjct: 1757 DRVRKATQQAEQLSNELATE--RSTAQKNESARQQLERQ 1793
Score = 50.4 bits (119), Expect = 4e-06
Identities = 87/425 (20%), Positives = 185/425 (43%), Gaps = 42/425 (9%)
Query: 73 ELHKKIQLLEGDRKAFFESSQWNIKKNQETISQLRKETKALELKL---LDLLKGD-EKVV 128
++ K + LE ++A E+ +K E + + T+ +L+L + LKG E+ +
Sbjct: 1522 DVGKNVHELEKSKRAL-ETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDL 1580
Query: 129 QAVIREWKWEKPYLKNRTGQALEHLDHRLREKVKQQNALRHQVVLRQRRLEELQLQHSLR 188
QA + + ++ L+ + L + L ++ KQ+ + L++L+LQ
Sbjct: 1581 QARDEQNEEKRRQLQRQ----LHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSA 1636
Query: 189 LLEMAEAQNRHTEVAKTMRNLENRLEKAQMKAQEAEHITSVYLQLKAYLMDESLNLENRL 248
+ EA + ++ M++ + LE A+ E T+ + KA ++ L ++ +
Sbjct: 1637 IKGREEAIKQLRKLQAQMKDFQRELEDARASRDEI-FATAKENEKKAKSLEADL-MQLQE 1694
Query: 249 DSMEAEVVRTKHELEALHVVNQEA--LNARDIAKNQLQYLEETLVR---ERKKRERYISE 303
D AE R + +LE + + A L+ R+ +++ + LE + + E ++ + +
Sbjct: 1695 DLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEA 1754
Query: 304 CKKRAEEKKLENERMERKTHREHLLLQSDDTIQDSLHAKEEELRQRWSMYQMEVIFGKVK 363
R + + E++ + E Q +++ + L + +ELR + +++ME G VK
Sbjct: 1755 MSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSK--LHEME---GAVK 1809
Query: 364 DATGTDETHSLVRRFLAQGDTFAQLETLKSENEQTLVRLKQEKQQLQRELEDLKYSGEAT 423
+ T + + +AQ + Q+E E + LKQ+ ++L+ L L+ E
Sbjct: 1810 SKFKS--TIAALEAKIAQLEE--QVEQEAREKQAATKSLKQKDKKLKEIL--LQVEDERK 1863
Query: 424 LVSQQKLQAE---------------AQERLKKEERRHAEAKDQLERALRAMQVAKDSLEH 468
+ Q K QAE A+E ++ + + +L+ A + + +
Sbjct: 1864 MAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNA 1923
Query: 469 LASKL 473
L SKL
Sbjct: 1924 LKSKL 1928
>gi|114155142 nuclear pore complex-associated protein TPR [Homo
sapiens]
Length = 2363
Score = 71.6 bits (174), Expect = 2e-12
Identities = 94/455 (20%), Positives = 181/455 (39%), Gaps = 84/455 (18%)
Query: 158 REKVKQQNALRHQ--VVLRQRRLEELQLQHSLRLLEMAEAQNRHTEV-AKTMRNLENRLE 214
R +V Q +LR++ V L +R L+ELQ + A+ +V AKTM E ++
Sbjct: 1213 RFEVAQVESLRYRQRVELLERELQELQ--------DSLNAEREKVQVTAKTMAQHEELMK 1264
Query: 215 KAQMKAQEAEHITSVYLQLKAYLMDESLNLENRLDSMEAEVVRTKHELEALHVVNQEALN 274
K + +V ++ L +E LE L M+A+V + + ++ L N E
Sbjct: 1265 KTETM--------NVVMETNKMLREEKERLEQDLQQMQAKVRKLELDILPLQEANAELSE 1316
Query: 275 ARDIAKNQLQYLEETLVRERKKRERYIS--------ECKKRAEEKKLENERMERKTHR-- 324
+ + + + LEE + R + + + +S E +K EK++ +R+++ T
Sbjct: 1317 KSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIG 1376
Query: 325 ---------------EHLLLQS-----------DDTIQDSLHAKEEELRQR--------- 349
L+QS +TIQ L AK +++++
Sbjct: 1377 RLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVKK 1436
Query: 350 -----------WSMYQMEVIFGKVKDATGTDETHSLVRRFLAQGDTFAQLETLKSENEQT 398
Q +V+ + + E H V+ +T Q ET E
Sbjct: 1437 IGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQAETKSKSLESQ 1496
Query: 399 LVRLKQEKQQLQRELEDLKYSGEATLVSQQKLQAEAQERLKKEERRHAEAKDQLERALRA 458
+ L++ + + E +L+ +L+ + Q+R +EE+ + ++ E+ +A
Sbjct: 1497 VENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKEEKTRKA 1556
Query: 459 MQVAKDSLEHLASKLIHITVEDGRFAGKE--LDPQADNY---VPNLLGLVEEKLLKLQAQ 513
+ AK + HLA +T E+ + LD Q D + L E ++ +L+ +
Sbjct: 1557 IVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQQKDELDVRITALKSQYEGRISRLERE 1616
Query: 514 LQGHDVQEMLCHIANREFLASLEGRLPEYNTRIAL 548
L+ H + H+ R+ ++PE +I L
Sbjct: 1617 LREHQER----HLEQRDEPQEPSNKVPEQQRQITL 1647
Score = 62.4 bits (150), Expect = 1e-09
Identities = 95/392 (24%), Positives = 175/392 (44%), Gaps = 51/392 (13%)
Query: 101 ETISQLRK-ETKALELK-LLDLLKGDEKVVQAVIREWKWEKPYLKNRTGQALEHLDHRLR 158
+ +SQLR+ E + +LK L + + QA++ + K T + ++++ RL+
Sbjct: 936 DLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLK 995
Query: 159 EKVKQQNALRHQVVLRQRRLEELQLQHSLRLLEMAEAQNRHTEVAKTMRNLENRLEKAQM 218
E + Q L +++ ++ +ELQ R +E E Q +E+ KT+ +++N +++A
Sbjct: 996 ESAEFQTQLEKKLMEVEKEKQELQ-DDKRRAIESMEQQL--SELKKTLSSVQNEVQEALQ 1052
Query: 219 KAQEAEHITSVYLQLKAYLMDESLNLENRLDSME----AEVVRTKHELEA-LHVVNQEAL 273
+A A L +E + R D E A + K+E E LH + EAL
Sbjct: 1053 RASTA-------------LSNEQ---QARRDCQEQAKIAVEAQNKYERELMLHAADVEAL 1096
Query: 274 NARDIAKNQLQYLEETLVRERKKRERYISECKKRAEEKKLENERMERKTHREHLLLQSDD 333
A +++ + + L +K E + ECK EE+ ERM K + + +D
Sbjct: 1097 QAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEER----ERM-LKDEVSKCVCRCED 1151
Query: 334 TIQDS--LHAKEEELRQRWSMYQMEVIFG----KVKDATGTDETHSLVRRFLAQGDTFAQ 387
+ + LH + E+L + E + G + + + E + RF+ + A+
Sbjct: 1152 LEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAE 1211
Query: 388 LETLKSENEQTLVRLKQEKQQLQRELEDLKYSGEATLVSQQ---KLQAEAQERLKKEERR 444
++ E +R +Q + L+REL++L+ S A Q K A+ +E +KK E
Sbjct: 1212 TRFEVAQVES--LRYRQRVELLERELQELQDSLNAEREKVQVTAKTMAQHEELMKKTETM 1269
Query: 445 HA---------EAKDQLERALRAMQVAKDSLE 467
+ E K++LE+ L+ MQ LE
Sbjct: 1270 NVVMETNKMLREEKERLEQDLQQMQAKVRKLE 1301
Score = 48.9 bits (115), Expect = 1e-05
Identities = 87/443 (19%), Positives = 178/443 (40%), Gaps = 76/443 (17%)
Query: 67 VHSQVAELHKKIQLLEGDRKAFFESSQWNIKKNQETISQLRKETKALELKLLDLLKGDEK 126
+ +Q+ K+ ++L+ + + + ++NQ+ + +K+ + + DL +EK
Sbjct: 714 ISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEK 773
Query: 127 VVQAVIR--EWKWEKPYLKNRTGQALEHLDHRLREKVKQQNALRHQVVLRQRRLEELQLQ 184
+ A +R K EK LK + + + L E+ + QN L + Q LE + +
Sbjct: 774 LAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQ-RGQNLLLTNLQTIQGILERSETE 832
Query: 185 HSLRLLEMAEAQNRHTEVAKTMRNLENRLEKAQMKAQEAEHITSVYLQLKAYLMDES--- 241
RL E E++ + LEN +E+ + ++ L K L E+
Sbjct: 833 TKQRLSSQIEKLEH--EISHLKKKLENEVEQRHTLTR---NLDVQLLDTKRQLDTETNLH 887
Query: 242 LNLENRLDSMEAEVVRTKHELEALHVVNQEALNARDIAKNQLQYLEETLVRERKKRERYI 301
LN + L + + E+ K L + V +A Q + ++ + +
Sbjct: 888 LNTKELLKNAQKEIATLKQHLSNMEV---------QVASQSSQRTGKGQPSNKEDVDDLV 938
Query: 302 SECKKRAEEKKLENERMERKTHREHLLLQSDDTIQDSLHAKEEELRQRWSMYQMEVIFGK 361
S+ ++ E+ ER++ T ++++SL+ KE+++
Sbjct: 939 SQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLN-KEKQV--------------- 982
Query: 362 VKDATGTDETHSLVRRFLAQGDTFAQLETLKSENEQTLVRLKQEKQQLQ----RELEDLK 417
T+E + L + F +++ E+ L+ +++EKQ+LQ R +E ++
Sbjct: 983 ------TEEVRKNIEVRLKESAEF------QTQLEKKLMEVEKEKQELQDDKRRAIESME 1030
Query: 418 YSGEATLVSQQKLQAEAQERLKK---------EERRH--------AEAKDQLERAL---- 456
+ +Q E QE L++ + RR EA+++ ER L
Sbjct: 1031 QQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHA 1090
Query: 457 ---RAMQVAKDSLEHLASKLIHI 476
A+Q AK+ + +AS H+
Sbjct: 1091 ADVEALQAAKEQVSKMASVRQHL 1113
Score = 45.8 bits (107), Expect = 1e-04
Identities = 106/546 (19%), Positives = 226/546 (41%), Gaps = 61/546 (11%)
Query: 95 NIKKNQETISQLRKETKALELKLLDLLKGDEKVVQAVIREWKWEKPYLKNRTGQALE--- 151
N++ +E +S+L ++ L+ L K E ++ ++E K ++ ++ + L
Sbjct: 225 NLENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTK-LKEAKEQQASMEEKFHNELNAHI 283
Query: 152 HLDHRLREKVKQQNALRHQVVLRQRRLEELQLQHSLRLLEMAEA----QNRHTEVAKTMR 207
L + + A +++ R +EEL H L L E EA Q+ EV ++
Sbjct: 284 KLSNLYKSAADDSEAKSNELT---RAVEEL---HKL-LKEAGEANKAIQDHLLEVEQSKD 336
Query: 208 NLENR-LEKAQMKAQEAEHITSVYLQLK---AYLMDESLNLENRLDSMEAEVVRTKHELE 263
+E LEK +E E+ + K A L +E L + + A++V+ +L
Sbjct: 337 QMEKEMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLT 396
Query: 264 ALH---VVNQEALNARDIAKNQLQYLEETLVRE--------RKKRERY------ISECKK 306
L+ V Q+ L + ++ + +V+E +++RE Y ++
Sbjct: 397 ELYNAYVETQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSV 456
Query: 307 RAEEKKLENERMER---KTHREHLLLQSDDTIQDSLHAKEEELRQRWSMYQMEVIFGK-- 361
+ E+ E +R++ K +++ +L+ D+ + + K+ + R + ++E G
Sbjct: 457 KLEQAMKEIQRLQEDTDKANKQSSVLERDNRRME-IQVKDLSQQIRVLLMELEEARGNHV 515
Query: 362 VKDATGTDETHSLVRRFLAQG-DTFAQLETLKSENEQTLVRLKQEKQQLQRELEDLKYSG 420
++D + S ++Q ++ +E L+ +N++ LV L++ + +RE ++ S
Sbjct: 516 IRDEEVSSADISSSSEVISQHLVSYRNIEELQQQNQRLLVALRELGETREREEQETTSSK 575
Query: 421 EATLVSQQKLQAEAQERLKKEERRHAEAKDQLERALRAMQVAKDSLEHLASKLIHITVED 480
L + + E+L+K + + D + R ++ +A L +++D
Sbjct: 576 ITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDD 635
Query: 481 GRFAGKELDPQADNYV--PNLLGLVEE--------KLLKLQAQLQGHDVQEMLCHIANRE 530
A P V P + ++E L +LQ + + ++ E
Sbjct: 636 VSLASTPKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNE 695
Query: 531 FLASLEGR---LPEYNTRIA--LPLATSKDKFFDEESEEEDNEVVTRASLKIRSQKLIES 585
L L+ + L NT+I+ L A+ + + + E E+ SL R+QKL +
Sbjct: 696 QLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREI---TSLHERNQKLTAT 752
Query: 586 HKKHRR 591
+K +
Sbjct: 753 TQKQEQ 758
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 71.6 bits (174), Expect = 2e-12
Identities = 91/429 (21%), Positives = 186/429 (43%), Gaps = 52/429 (12%)
Query: 66 SVHSQVAELHKKIQLLEGDRKAFFESSQWNIKKNQETISQLRKETKALELKLLDLLKGDE 125
S+ SQ+ +K+ ++LEG + SS+ +++ + +SQ E ++ LL+ K D
Sbjct: 835 SLQSQLQ--NKESEVLEGAERVRHISSK--VEELSQALSQKELEITKMDQLLLEK-KRDV 889
Query: 126 KVVQAVIREWKWEKPYLKNRTGQALEHLDHRLREKVKQQNALRHQVVLRQRRLEELQLQH 185
+ +Q I E Q + + + EK+ Q N + + + + L+E
Sbjct: 890 ETLQQTIEE-----------KDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKE----- 933
Query: 186 SLRLLEMAEAQNRHTEVAKTMRNLENRLEKAQMKAQEAEHITSVYLQLKAYLMDESLNLE 245
L LL AE + E + + + L++ + A I+ LQ + L+ + E
Sbjct: 934 QLNLLSRAEEAKK--EQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKEN--E 989
Query: 246 NRLDSMEAEVVRTKHELEALHVVNQEALNARDIAKNQ--LQYLEETLVRERKKRERYISE 303
R ++A ++ K L+ + + +E N +D +K + L E V E K+ + Y +
Sbjct: 990 QRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETERGEVEEDKENKEYSEK 1049
Query: 304 C------------KKRAEEKKLE--------NERMERKTHREHLLLQSDDTIQDS---LH 340
C K+ EK++E E++ + + L+ Q + T+QD +
Sbjct: 1050 CVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQID 1109
Query: 341 AKEEELRQRWSMYQMEVIFGKVKDATGTDETHSLVRRFLAQGDTFAQLETLKSENEQTLV 400
+ E+ + ++ Q + DA+ D + + E K E E+ ++
Sbjct: 1110 LLQAEISENQAIIQKLITSNT--DASDGDSVALVKETVVISPPCTGSSEHWKPELEEKIL 1167
Query: 401 RLKQEKQQLQRELEDLKYSGEATLVSQQKLQAEAQERLKKEERRHAEAKDQLERALRAMQ 460
L++EK+QLQ++L++ S +A L Q+ + +E LK+++ + ++Q + + +
Sbjct: 1168 ALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKENE 1227
Query: 461 VAKDSLEHL 469
D L L
Sbjct: 1228 NIGDQLRQL 1236
Score = 53.9 bits (128), Expect = 4e-07
Identities = 76/370 (20%), Positives = 157/370 (42%), Gaps = 31/370 (8%)
Query: 100 QETISQLRKETKALELKLLDL---LKGDEKVVQAVIREWKWEKPYLKNRTGQALEHL--- 153
Q+ L++E KA + K+ L K + I E K + + Q+ E L
Sbjct: 76 QQKDEALQEERKAADNKIKKLKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKH 135
Query: 154 DHRLREKVKQQNALRHQVVLRQRRLEELQLQHSLRLLEMAEAQNRHTEVAKTMRNLENRL 213
D E+ + ++H++ ++ + LQ Q L A+A+ + A++ +E +
Sbjct: 136 DKSSTEEEMEIEKIKHKLQEKEELISTLQAQ-----LTQAQAE----QPAQSSTEMEEFV 186
Query: 214 EKAQMKAQEAEHITSVYLQLKAYLMDESLNLENRLDSMEAEVVRTKHELEALHVVNQ--- 270
Q ++ E I+++ QL +++ R E HE E L +V Q
Sbjct: 187 MMKQQLQEKEEFISTLQAQLSQTQAEQAAQQVVREKDARFETQVRLHEDELLQLVTQADV 246
Query: 271 --EALNARDIAKNQLQYLEETLVRERKKRERYISECKKRAEEKKLENERMERKTHREHLL 328
E + + +L+ EE+LV + + E + ++ ++++++ EH
Sbjct: 247 ETEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQM-EAEH-- 303
Query: 329 LQSDDTIQDSLHAKEEELRQRWSMYQMEVIFGKVKDATGTDETHSLVRRFLAQGDTFAQL 388
+T+++++ + EE + ++EV K+ +E H L+ +F G A+L
Sbjct: 304 ----NTLRNTVETEREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAEL 359
Query: 389 ETLKSENEQTLVRLKQEKQ----QLQRELEDLKYSGEATLVSQQKLQAEAQERLKKEERR 444
E+ S EQ +EK LQ+ ++L+ + +A KL + E+ + +
Sbjct: 360 ESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQT 419
Query: 445 HAEAKDQLER 454
+ +DQL++
Sbjct: 420 IQQLEDQLQQ 429
Score = 52.0 bits (123), Expect = 2e-06
Identities = 126/570 (22%), Positives = 234/570 (41%), Gaps = 68/570 (11%)
Query: 64 KPSVHSQVAELHKKIQLLEGDRKAFFESSQWNIKKNQETISQLRKETKALELKLLDLLKG 123
KP + ++ L K+ + L+ + S + +KK QE LR+E K K
Sbjct: 1159 KPELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQ--------QKD 1210
Query: 124 DEKVVQAVIREWKWEKPYLKNRTGQALEHLDHRLREKV-------KQQNALRHQVVLRQR 176
D +Q E E G L L ++RE + QQ + L +
Sbjct: 1211 DYNRLQEQFDEQSKE----NENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEP 1266
Query: 177 RLEELQLQHSLRLLE--MAEAQNRHTEVAKTMRNLENRLE-KAQMKAQEAEHITSVYLQL 233
+ + H+ +LE + H+E A ++ + + KAQ+K EAE V L+L
Sbjct: 1267 LFKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAE---KVELEL 1323
Query: 234 K--------AYLMDESLNLENRLD--SMEAEVVRT-KHELEALHVVNQEALNARDIAKNQ 282
K +E L+ +++ +E E ++T HE E Q+ L + +
Sbjct: 1324 KVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAG 1383
Query: 283 LQYLEE------TLVRERKKRERYISECKKRAEEKKLENERMERKTHREHLLLQSDDTIQ 336
L++L E L + K+E +S + EK+ +++ + + L+++ T Q
Sbjct: 1384 LEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHT-Q 1442
Query: 337 DSLHAKEEELRQRWSMYQMEVIFGKVKDATGTDETHS--LVRRFLAQGDTFAQLETLKSE 394
+ AKE + +R Q+E+ K K +E+ + ++R L Q ++ E LK E
Sbjct: 1443 LEMQAKEHD--ERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKL-QAALISRKEALK-E 1498
Query: 395 NEQTLVRLKQEKQQLQRELEDLKYSGEATLVSQQKLQAEAQERLKKEERRHAEAKDQLER 454
N+ L + ++R + L E+ + +Q K + RL + + +++R
Sbjct: 1499 NKSLQEELSLARGTIERLTKSLA-DVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDR 1557
Query: 455 ALRAMQVAKDSLEHLASKLIHITVEDGRFAGKELD-------PQADNYVPNLLGLVEEKL 507
+L Q S E L L +T ED KE++ ++ + L +E
Sbjct: 1558 SLLENQSLSSSCESLKLALEGLT-EDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYE 1616
Query: 508 LKLQAQLQGHDVQEMLCHI--ANREFLASLEGRL--PEYNTRIALPLATSKDKFFDEESE 563
+ LQ+ + E + H+ A R+ L G+L E N + ++ + + E E
Sbjct: 1617 ILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKK------ETEKQLQEAEQE 1670
Query: 564 EEDNEVVTRASLKIRSQKLIESHKKHRRSR 593
E+ + R K + QK++E +++ R R
Sbjct: 1671 MEEMKEKMRKFAKSKQQKILELEEENDRLR 1700
Score = 49.7 bits (117), Expect = 8e-06
Identities = 87/460 (18%), Positives = 182/460 (39%), Gaps = 51/460 (11%)
Query: 170 QVVLRQRRLEELQLQHSLRLLEMAEAQNRHTEVAKTMRNLENRLEKAQMKAQEAEHITSV 229
++ + + +LQ Q + + LE+ + E +L+ +LE +Q++ EH+ +
Sbjct: 1331 ELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLREL 1390
Query: 230 YLQLK-------------AYLMDESLNLENRLDSMEAEVVRTKHELEALHVVNQEALNAR 276
+L +YL + E L ++ E++ + ++ALH +
Sbjct: 1391 QPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEH 1450
Query: 277 DIAKNQLQYLEETLVRERKKRERYISECK-KRAEEKKLENERMERK-THREHLLLQSD-- 332
D +++ L+ L ++K E E + K+ ++KL+ + RK +E+ LQ +
Sbjct: 1451 D---ERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELS 1507
Query: 333 ------DTIQDSLHAKEEELRQRWSMYQMEVIFGKVKDATGTDETHSLV----RRFLAQG 382
+ + SL E ++ + + + + G++ A +E L+ R L
Sbjct: 1508 LARGTIERLTKSLADVESQVSAQ--NKEKDTVLGRL--ALLQEERDKLITEMDRSLLENQ 1563
Query: 383 DTFAQLETLKSENEQTLVRLKQEKQQLQRELEDLKYSGEATLVSQQKLQAEAQERLKKEE 442
+ E+LK L L ++K++L +E+E LK S A Q+ E Q+ +
Sbjct: 1564 SLSSSCESLK----LALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILL 1619
Query: 443 RRHAEAKDQLERALRAMQVAKDSLEHLASKL--IHITVEDGRFAGKELDPQADNYVPNLL 500
+ + ++ ER ++ + + L KL ++ +E + + + +
Sbjct: 1620 QSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMR 1679
Query: 501 GLVEEKLLKLQAQLQGHDVQEMLCHIAN------REFLASLEGRLPEYNTRIALPLATSK 554
+ K K+ + +D H A E L S + E R+ + T
Sbjct: 1680 KFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYETLS 1739
Query: 555 DKFFDEESE-----EEDNEVVTRASLKIRSQKLIESHKKH 589
KF SE EE ++ + + Q +E+ +KH
Sbjct: 1740 KKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKH 1779
Score = 49.3 bits (116), Expect = 1e-05
Identities = 97/472 (20%), Positives = 188/472 (39%), Gaps = 62/472 (13%)
Query: 72 AELHKKIQLLEGDRKAFFESSQWNIKKNQETISQLRKETKALELKLLDLLKGDEKVVQAV 131
AEL + LE KA E +I Q+T +L+ AL+ + LL+ +K QAV
Sbjct: 357 AELESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSACDALKDQNSKLLQ--DKNEQAV 414
Query: 132 IREWKWEKPYLKNRTGQALEHLDHRLREKVKQQNALRHQVVLRQRR-LEELQLQHSLRLL 190
++ Q ++ L+ +L++K K+ + +++ L+Q +
Sbjct: 415 -------------QSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEG 461
Query: 191 EMAEAQNRHTEVAKTMRNLENRLEKAQMKAQEAEHITSVYLQLKAYLMDESLNLENRLDS 250
A + + K + LEN + + E E + + +L + + L +NR
Sbjct: 462 TQAVTEENIASLQKRVVELENEKGALLLSSIELEELKAENEKLSSQI--TLLEAQNRTGE 519
Query: 251 MEAEVVRTKHELEALHVVNQEALNARDIAKNQLQYLEETLVRERKKRERYISECKKRAEE 310
+ EV E+ + + N+ + +A + ++ LE T ++ K+ + E K+ EE
Sbjct: 520 ADREV----SEISIVDIANKRSSSAEESGQD---VLENTFSQKHKELSVLLLEMKEAQEE 572
Query: 311 -----KKLENERMERKTH-----REHLLLQSDDTIQDSLHAKEEELRQRWS-MYQMEVIF 359
+L+ +R E H +E ++ + + E+ Q + M E
Sbjct: 573 IAFLKLQLQGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSL 632
Query: 360 GKVKDATGTDETHSLVRRFLAQGDTFAQLETLKSENEQTLVRLKQEKQQLQRELEDLKYS 419
V+ + E S ++ D +L++ K + +++L + Q Q ELE LK
Sbjct: 633 PAVEKEQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQ 692
Query: 420 --------GEATLVSQQKLQAEAQE-----RLKKEERRHAEAKDQLERALRAMQVAKDSL 466
+A + ++ L +A+E +L +E +++A D A A+ +D L
Sbjct: 693 ILELELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNA---DNNSSAFTALSEERDQL 749
Query: 467 EHLASKLIHITVEDGRFAGKELDPQADNYVPNLLGLVEEKLLKLQAQLQGHD 518
+L +T EL Q NL ++ L ++Q HD
Sbjct: 750 LSQVKELSMVT---------ELRAQVKQLEMNLAEAERQRRLDYESQ-TAHD 791
Score = 48.5 bits (114), Expect = 2e-05
Identities = 87/391 (22%), Positives = 158/391 (40%), Gaps = 67/391 (17%)
Query: 180 ELQLQHSLRLLEMAEAQNRHTEVAK-----------TMRNLENRLEKAQMKAQEAEHITS 228
E ++Q LR+L+ ++ + V + T N++ Q++ EAEH T
Sbjct: 247 ETEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNT- 305
Query: 229 VYLQLKAYLMDESLNLENRLDSMEAEVVRTK---HEL--EALHVVNQ--EALNARDIAKN 281
L+ + E + L+ ME EV K H L E H++ Q +A A+ ++
Sbjct: 306 ----LRNTVETEREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELES 361
Query: 282 QLQYLEETLVRERKKRERYISECKKRAEEKK-----LENERMERKTHREHLLLQSDDTIQ 336
+ LE+ E +++ +I +K +E + L+++ + + +QS TIQ
Sbjct: 362 RYSALEQKHKAEMEEKTSHILSLQKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQ 421
Query: 337 ---DSLHAKEEELRQRWSMYQMEVIFGKVKDATGTDETHSLVRRFLAQGDTFAQLETLKS 393
D L K +E+ Q L R L Q +T +Q
Sbjct: 422 QLEDQLQQKSKEISQ------------------------FLNRLPLQQHETASQTSFPDV 457
Query: 394 ENEQTLVRLKQEKQQLQRELEDLKYSGEATLVSQQKLQAEAQERLKKEERRHAEAKDQLE 453
NE T ++ LQ+ + +L+ A L+S +L E LK E + + LE
Sbjct: 458 YNEGTQAVTEENIASLQKRVVELENEKGALLLSSIEL-----EELKAENEKLSSQITLLE 512
Query: 454 RALRA----MQVAKDSLEHLASKLIHITVEDGRFAGKELDPQADNYVPNLL---GLVEEK 506
R +V++ S+ +A+K E G+ + Q + LL +E+
Sbjct: 513 AQNRTGEADREVSEISIVDIANKRSSSAEESGQDVLENTFSQKHKELSVLLLEMKEAQEE 572
Query: 507 LLKLQAQLQGHDVQEMLCHIANREFLASLEG 537
+ L+ QLQG +E + +++ + +EG
Sbjct: 573 IAFLKLQLQGKRAEEADHEVLDQKEMKQMEG 603
Score = 48.5 bits (114), Expect = 2e-05
Identities = 97/451 (21%), Positives = 176/451 (39%), Gaps = 84/451 (18%)
Query: 174 RQRRLEELQLQHSLRLLEMAEAQNRHTEVAKTMRNLENRLEKAQMKAQEAEHITSVYLQL 233
+++ ++E++ S ++ E E Q +H E+ K L E +A+ +H+ Q
Sbjct: 1583 KEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQ- 1641
Query: 234 KAYLMDESLNLENRLDSMEAEVVRTKHELEALHVVNQEALNARDIAKNQLQYLEETLVRE 293
E L +L S EA T + QLQ E+ +
Sbjct: 1642 ------EKQELYGKLRSTEANKKET---------------------EKQLQEAEQEMEEM 1674
Query: 294 RKKRERYISECKKRAEEKKLENERMERKTHRE--------HLLLQSDDTIQDSLHAKEEE 345
++K ++ +++ E + EN+R+ + H LL S+ ++++ L + E
Sbjct: 1675 KEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKME 1734
Query: 346 LRQRWSMYQMEVIFGKVKDATGTDETHSLVRRFLAQGDTFAQLETLKSENEQTLVRLKQE 405
+Q + KD+ ++E L + A LE + + QT V ++
Sbjct: 1735 YETLSKKFQSLM---SEKDSL-SEEVQDLKHQIEGNVSKQANLEATEKHDNQTNV-TEEG 1789
Query: 406 KQQLQRELED---LKYSGEATLVSQQKLQAEAQERLKKEERRHAEAK------DQLERAL 456
Q + E E+ L S T A + K+ H E DQL+ +
Sbjct: 1790 TQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERI 1849
Query: 457 RAMQVAK-------DSLEHLASKLI-HITVEDGRFAGKELDPQADNYVPNLLG-LVEEKL 507
++ K +LE+ + L+ I+ +DG K L + NLL ++E+L
Sbjct: 1850 AGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGEL--KMLQEEVTKM--NLLNQQIQEEL 1905
Query: 508 -----LKLQAQLQGHDVQEMLCHIANREFLASLEGRLPEY-----NTRIALPLATSKDKF 557
LK A+ + D++E L + LA L G + Y + +I L S+ K
Sbjct: 1906 SRVTKLKETAEEEKDDLEERLMN-----QLAELNGSIGNYCQDVTDAQIKNELLESEMKN 1960
Query: 558 FDE---ESEEEDNEVV---TRASLKIRSQKL 582
+ E EEE ++V T+ +IR + L
Sbjct: 1961 LKKCVSELEEEKQQLVKEKTKVESEIRKEYL 1991
Score = 48.1 bits (113), Expect = 2e-05
Identities = 95/483 (19%), Positives = 187/483 (38%), Gaps = 45/483 (9%)
Query: 69 SQVAELHKKIQLLEGDRKAFFESSQWNIKKNQETISQLRKETKALELKLLDLLKGDEKVV 128
+Q+ E K I+ +KA +S ++ Q ++ + + LE + L ++ ++++
Sbjct: 2439 NQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLI 2498
Query: 129 QAVIREWKWEKPYLKNRTGQALEHLDHRLREKVKQQNALRHQVVLRQRRLEELQLQHSLR 188
Q E E LK H+D E K L + R+ + + ++ S +
Sbjct: 2499 Q----EAAAENNKLKEEIRGLRSHMDDLNSENAKLDAEL---IQYREDLNQVITIKDSQQ 2551
Query: 189 --LLEMAEAQNRHTEVAKTMRNLENRLEKAQMKAQEAEHITSVYLQLKAYLMDESLNLEN 246
LLE+ QN+ LEN+ K + K +E+E + L +E +L
Sbjct: 2552 KQLLEVQLQQNKE---------LENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSK 2602
Query: 247 RLDSMEAEVVRTKHELEALHVVNQEAL-NARDIAKNQLQYLEETLVRERKKRERYISE-- 303
++S++ + + ++ AL L +A+ K + + L +KR + E
Sbjct: 2603 EIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEEL 2662
Query: 304 -CKKRAEEKKLENERMERKTHREHLLLQSDDTIQDSLHAKEEELRQRWSMYQMEVIFGKV 362
C ++ KK+ +E K +E L D I + + E +R + +++ +
Sbjct: 2663 VCVQKEAAKKV--GEIEDKLKKELKHLHHDAGI---MRNETETAEERVAELARDLVEMEQ 2717
Query: 363 KDATGTDETHSLVRRFLAQGDTFAQLETLKSENEQTLVRLKQEKQQLQRELEDLKYSG-- 420
K T E L + + G + + L+ + + L LK++ +EL LK G
Sbjct: 2718 KLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLKEQGLL 2777
Query: 421 --------EATLVSQQKLQAEAQERLKK-------EERRHAEAKDQLERALRAMQVAKDS 465
T S + + L+K ++ + QLE + +Q +
Sbjct: 2778 NRERDALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKA 2837
Query: 466 LEHLASKLIHITVEDGRFAGKELDPQADNYVPNLLGLVEEKLLKLQAQLQGHDVQEMLCH 525
+ L ++ H+ E +F E Q P+ + L K + LQ +D +L
Sbjct: 2838 MASLQNERDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQ-NDRDRLLKE 2896
Query: 526 IAN 528
+ N
Sbjct: 2897 LKN 2899
Score = 43.5 bits (101), Expect = 5e-04
Identities = 70/299 (23%), Positives = 124/299 (41%), Gaps = 36/299 (12%)
Query: 157 LREKVKQQNALRHQVVLRQRRLEELQLQHSLRLLEMAEA-QNRHTEVAKTMRNLENRLEK 215
L+E+V + N L Q+ R+ +L+ ++ E N+ E+ ++ N +
Sbjct: 1887 LQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTD 1946
Query: 216 AQMKAQEAEHITSVYLQLKAYLMDESLNLENRLDSMEAEVVRTKHELEALHVVNQEALNA 275
AQ+K + E + + L +E L +E+E+ K LE + +E N
Sbjct: 1947 AQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEI--RKEYLEKIQGAQKEPGN- 2003
Query: 276 RDIAKNQLQYLEETLVRERKKRERYISECKKRAEEKKLENERMERKTHREHLLLQSDDTI 335
K+ + L+E L++E+++ + + + R +EK ER + Q D I
Sbjct: 2004 ----KSHAKELQE-LLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEI 2058
Query: 336 QDSLHAKEEELRQRWSMYQMEVIFGKVKDATGTDETHSLVRRFLAQGDTFAQLETLKSEN 395
A+ E R++ Q E+ KV D+T S R LA D + L+S
Sbjct: 2059 TKENLAQAVEHRKK---AQAELASFKVL----LDDTQSEAARVLA--DNLKLKKELQSNK 2109
Query: 396 EQTLVRLKQEKQQLQRELEDLKYSGEATLVSQQKLQAEAQERLKKEERRHAEAKDQLER 454
E ++KQ+ + L+R LE +A+E+ KE++ E D L R
Sbjct: 2110 ESVKSQMKQKDEDLERRLE------------------QAEEKHLKEKKNMQEKLDALRR 2150
Score = 41.6 bits (96), Expect = 0.002
Identities = 114/592 (19%), Positives = 233/592 (39%), Gaps = 82/592 (13%)
Query: 66 SVHSQVAELHKKIQLLEGDRKAFFESSQWNIKKNQETISQLRKETKALELKLLDLLKGDE 125
+V + EL+ K++ E ++K + Q ++ +E ++RK K+ + K+L+L + ++
Sbjct: 1638 AVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEEND 1697
Query: 126 KVVQAVIREWKWEKPYLK-------------NRTGQALEHLDHRLREKVKQQNALRHQVV 172
++ V K ++ R E L + + + ++++L +V
Sbjct: 1698 RLRAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQ 1757
Query: 173 LRQRRLE-ELQLQHSLRLLEMAEAQNRHTEVA----------------KTMRNLENRLEK 215
+ ++E + Q +L E + Q TE T +
Sbjct: 1758 DLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPS 1817
Query: 216 AQMKAQEAEHITSVYLQLKAYLMDESLNLENRLDSMEAEVVRTKHELEALHVVNQEALNA 275
A+ S + ++ YL L+ R+ +E E + K + L L+
Sbjct: 1818 AKSANPAVSKDFSSHDEINNYLQQID-QLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQ 1876
Query: 276 RDIAKNQLQYLEETLVRERKKRERY------ISECKKRAEEKK--LENERMERKTHREHL 327
+L+ L+E + + ++ +++ K+ AEE+K LE M +
Sbjct: 1877 ISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGS 1936
Query: 328 LLQ-----SDDTIQDSLHAKEEELRQRWSMYQMEVIFGKVKDATGTDETHSLVRRFLAQG 382
+ +D I++ L E + ++ E VK+ T + S +R+ +
Sbjct: 1937 IGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKT---KVESEIRKEYLEK 1993
Query: 383 DTFAQLETLKSENEQTLVRLKQEKQQLQRELED--LKYSG-----EATLVSQQKLQAEAQ 435
AQ E + + L L +EKQQ ++L+ ++Y E T+ + + +Q E+Q
Sbjct: 1994 IQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQ 2053
Query: 436 ERLKKEERRHAEAKDQLERA---LRAMQVAKDSLEHLASKL------IHITVEDGRFAGK 486
+ L+ + A+A + ++A L + +V D + A+++ + ++ + + K
Sbjct: 2054 KDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVK 2113
Query: 487 ELDPQADNYVPNLLGLVEEKLLKLQAQLQGHDVQEMLCHIANREFLASLEGRLPEYNTRI 546
Q D + L EEK LK + ++QE L A R LE + E +
Sbjct: 2114 SQMKQKDEDLERRLEQAEEKHLK-----EKKNMQEKL--DALRREKVHLEETIGEIQVTL 2166
Query: 547 ALPLATSKDKFFDEESEEEDNEVV-------TRASLKIRSQKLIESHKKHRR 591
KDK + E D+ V + +SL+ ++I+ KK R
Sbjct: 2167 -----NKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWER 2213
Score = 38.5 bits (88), Expect = 0.018
Identities = 61/301 (20%), Positives = 125/301 (41%), Gaps = 41/301 (13%)
Query: 214 EKAQMKAQEAEHITSVYLQLKAYLMDESLNLENRLDSMEAEVVRTKHELEALHVVNQEAL 273
E Q + AE + ++LK + + + L+ + ++++ E ++++ L + + L
Sbjct: 48 EDVQERLAYAEQLV---VELKDIIRQKDVQLQQKDEALQEERKAADNKIKKLKLHAKAKL 104
Query: 274 NARDIAKNQLQYLEETLVRERKKRERYISECKKRAEEKKLENERMERKTHREHLLL---- 329
+ + +++ T++ + E +S+ K + E+++E E+++ K + L+
Sbjct: 105 TSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQ 164
Query: 330 ------QSDDTIQDS------------LHAKEE---ELRQRWSMYQMEVIFGKV---KDA 365
Q++ Q S L KEE L+ + S Q E +V KDA
Sbjct: 165 AQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAAQQVVREKDA 224
Query: 366 T-------GTDETHSLVRRFLAQGDTFAQLETLK---SENEQTLVRLKQEKQQLQRELED 415
DE LV + + + +L L+ E+E++LV Q LQ+EL
Sbjct: 225 RFETQVRLHEDELLQLVTQADVETEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQELTA 284
Query: 416 LKYSGEATLVSQQKLQAEAQERLKKEERRHAEAKDQLERALRAMQVAKDSLEHLASKLIH 475
+ + Q+++AE E E+K LE+ + K S +L ++ H
Sbjct: 285 AEQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELEVAERKLSFHNLQEEMHH 344
Query: 476 I 476
+
Sbjct: 345 L 345
Score = 32.0 bits (71), Expect = 1.7
Identities = 80/403 (19%), Positives = 164/403 (40%), Gaps = 71/403 (17%)
Query: 68 HSQVAELHKKIQLLEGDRKAF------FESSQWNIKKNQETISQLRKETKALELKLLDLL 121
++QV K + L+ +R F S+ +++ S E ++L+ K + L
Sbjct: 2828 YNQVQSFSKAMASLQNERDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLK-KAMSSL 2886
Query: 122 KGDEKVVQAVIREWK-WEKPYLK-NRTGQALEHLDHRLREKVKQQNALRHQVVLRQRRLE 179
+ D +++E K ++ YL+ N+ L L +L+E + A Q++ + R E
Sbjct: 2887 QNDR---DRLLKELKNLQQQYLQINQEITELHPLKAQLQEYQDKTKAF--QIMQEELRQE 2941
Query: 180 ELQLQHSLRLLEMAEAQNRHTEVAKTMRNLENRLEKAQMKAQEAEHITSVYLQLKAYLMD 239
L QH L L M ++ E R E L K Q+ H+ ++ +L++
Sbjct: 2942 NLSWQHELHQLRMEKSSWEIHE----RRMKEQYLMAISDKDQQLSHLQNLIRELRS---- 2993
Query: 240 ESLNLENRLDSMEAEVVRTKHELEALHVVNQEALNARDIAKNQLQYLEETLVRERKKRER 299
S + + ++ +++ +A + E + D ++N LV E +
Sbjct: 2994 ---------SSSQTQPLKVQYQRQA----SPETSASPDGSQN--------LVYETELLRT 3032
Query: 300 YISECKKRAEEKKLENERMERKTHREHLLLQSDDTIQDSLHAKEEELRQRWSMY-----Q 354
+++ K +K+L R+++ LL+ +T+ L + LR+ Y
Sbjct: 3033 QLNDSLKEIHQKEL---RIQQLNSNFSQLLEEKNTLSIQLCDTSQSLRENQQHYGDLLNH 3089
Query: 355 MEVIFGKVKD----------ATGTDETHSLVRRFLAQGDTFAQLETLKSENEQTLVRLKQ 404
V+ +V++ A G + + V R + + + + SE +Q L +Q
Sbjct: 3090 CAVLEKQVQELQAGPLNIDVAPGAPQEKNGVHR-KSDPEELREPQQSFSEAQQQLCNTRQ 3148
Query: 405 EKQQLQRELEDLKYSGEATLVSQQKLQAEAQERLKKEERRHAE 447
E +L++ LE+ + Q++ AE + +E+ R E
Sbjct: 3149 EVNELRKLLEEER---------DQRVAAENALSVAEEQIRRLE 3182
>gi|38044112 restin isoform b [Homo sapiens]
Length = 1392
Score = 71.2 bits (173), Expect = 2e-12
Identities = 120/603 (19%), Positives = 252/603 (41%), Gaps = 83/603 (13%)
Query: 57 SFHRGAGKPSVHSQVAELHKKIQLLEGDRKAFFESSQWNIKKNQETISQLR--KETKALE 114
SF +G G + ++ AEL +I+ + D + E+ Q NQ+ + KE +AL
Sbjct: 598 SFSKGLGTET--AEFAELKTQIEKMRLDYQHEIENLQ-----NQQDSERAAHAKEMEALR 650
Query: 115 LKLLDLLKGDEKVVQAVIREW-KWEKPYLKNR--TGQALEHLDHRLREKVKQQNALRHQV 171
KL+ ++K E ++A+ + K E +L T L+ + +++E Q Q
Sbjct: 651 AKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQT 710
Query: 172 VLRQRRLEELQLQHSLRLLEMAEAQNRHTEVAKTMRNLENRLEKAQMKAQEAEHITSVYL 231
+ +L+ +LL++ + +E M+ L +LE A+ + + E +
Sbjct: 711 KVIDNFTSQLKATEE-KLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAES 769
Query: 232 QLKAYLMDESLNLENRLDSME---AEVVRTKHELEA-LHVVNQEALNARDIAKNQLQYLE 287
+ + E E +L +++ +EV + K LE L ++ ++ A + A + + ++
Sbjct: 770 SKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQ 829
Query: 288 ETLVRERKKRERY---ISECKKRAEEKKLENERMERKTHREHLLLQSDDTIQDSL----- 339
ET+ + +K E++ S+ +K E + K RE L+++ + +++ +
Sbjct: 830 ETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMK 889
Query: 340 -----HAKEEELRQRWSMYQMEVIFGKVKDATGTDETHSLVRRFLAQGDTFAQLETLKSE 394
++ ++ + + +V ++K T +E S +++ + T+K+E
Sbjct: 890 MSGDNSSQLTKMNDELRLKERDVEELQLK-LTKANENASFLQKSIED-------MTVKAE 941
Query: 395 NEQTLVRLK--QEKQQLQRELEDLKYSGEATLVSQQKLQAEAQERLKKEERRHAEAKDQL 452
Q K +EK++L+R+L DL+ E + Q+L+A + + + +H E L
Sbjct: 942 QSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNL 1001
Query: 453 ERAL-------------------------------RAMQVAKDSLEHLASKLIHIT---- 477
++ L +A Q A+D+++ + T
Sbjct: 1002 QKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLA 1061
Query: 478 -VEDGRFAGKELDPQADNYVPNLLGLVEE-KLLKLQAQLQGHDVQEMLCHIANREFLASL 535
+ED + +L + D N L VEE K ++ ++E I + A+
Sbjct: 1062 SLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQ 1121
Query: 536 EGR----LPEYNTRIALPLATSKDKFFDEESEEEDNEVVTR--ASLKIRSQKLIESHKKH 589
+ + L E N ++A L S+D+ + EE+ V+ +K R K I+ +
Sbjct: 1122 KSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEE 1181
Query: 590 RRS 592
+ S
Sbjct: 1182 KAS 1184
>gi|4506751 restin isoform a [Homo sapiens]
Length = 1427
Score = 71.2 bits (173), Expect = 2e-12
Identities = 120/603 (19%), Positives = 252/603 (41%), Gaps = 83/603 (13%)
Query: 57 SFHRGAGKPSVHSQVAELHKKIQLLEGDRKAFFESSQWNIKKNQETISQLR--KETKALE 114
SF +G G + ++ AEL +I+ + D + E+ Q NQ+ + KE +AL
Sbjct: 633 SFSKGLGTET--AEFAELKTQIEKMRLDYQHEIENLQ-----NQQDSERAAHAKEMEALR 685
Query: 115 LKLLDLLKGDEKVVQAVIREW-KWEKPYLKNR--TGQALEHLDHRLREKVKQQNALRHQV 171
KL+ ++K E ++A+ + K E +L T L+ + +++E Q Q
Sbjct: 686 AKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQT 745
Query: 172 VLRQRRLEELQLQHSLRLLEMAEAQNRHTEVAKTMRNLENRLEKAQMKAQEAEHITSVYL 231
+ +L+ +LL++ + +E M+ L +LE A+ + + E +
Sbjct: 746 KVIDNFTSQLKATEE-KLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAES 804
Query: 232 QLKAYLMDESLNLENRLDSME---AEVVRTKHELEA-LHVVNQEALNARDIAKNQLQYLE 287
+ + E E +L +++ +EV + K LE L ++ ++ A + A + + ++
Sbjct: 805 SKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQ 864
Query: 288 ETLVRERKKRERY---ISECKKRAEEKKLENERMERKTHREHLLLQSDDTIQDSL----- 339
ET+ + +K E++ S+ +K E + K RE L+++ + +++ +
Sbjct: 865 ETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMK 924
Query: 340 -----HAKEEELRQRWSMYQMEVIFGKVKDATGTDETHSLVRRFLAQGDTFAQLETLKSE 394
++ ++ + + +V ++K T +E S +++ + T+K+E
Sbjct: 925 MSGDNSSQLTKMNDELRLKERDVEELQLK-LTKANENASFLQKSIED-------MTVKAE 976
Query: 395 NEQTLVRLK--QEKQQLQRELEDLKYSGEATLVSQQKLQAEAQERLKKEERRHAEAKDQL 452
Q K +EK++L+R+L DL+ E + Q+L+A + + + +H E L
Sbjct: 977 QSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNL 1036
Query: 453 ERAL-------------------------------RAMQVAKDSLEHLASKLIHIT---- 477
++ L +A Q A+D+++ + T
Sbjct: 1037 QKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLA 1096
Query: 478 -VEDGRFAGKELDPQADNYVPNLLGLVEE-KLLKLQAQLQGHDVQEMLCHIANREFLASL 535
+ED + +L + D N L VEE K ++ ++E I + A+
Sbjct: 1097 SLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQ 1156
Query: 536 EGR----LPEYNTRIALPLATSKDKFFDEESEEEDNEVVTR--ASLKIRSQKLIESHKKH 589
+ + L E N ++A L S+D+ + EE+ V+ +K R K I+ +
Sbjct: 1157 KSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEE 1216
Query: 590 RRS 592
+ S
Sbjct: 1217 KAS 1219
Score = 36.6 bits (83), Expect = 0.067
Identities = 47/182 (25%), Positives = 87/182 (47%), Gaps = 16/182 (8%)
Query: 276 RDIAKNQLQYLEETLVRERKKRERYISECKKRAEEKKLENE-RMERKTHREHLL-LQSD- 332
++ K + Q++E+ L +R K + ++E E + R H +H+L L++
Sbjct: 354 QEALKEKQQHIEQLLAERDLERAEV---AKATSHVGEIEQELALARDGHDQHVLELEAKM 410
Query: 333 DTIQDSLHAKEEELRQRWSMYQMEVIFGKVKDATGTDETHSLVRRFLAQGDTFAQLETLK 392
D ++ + A + E + + Q+E KV+D E S+ + L +T +LE +
Sbjct: 411 DQLRTMVEAADREKVEL--LNQLEEEKRKVEDLQFRVEEESITKGDL---ETQTKLEHAR 465
Query: 393 -SENEQTLVRLKQEKQQLQRELEDLKYSGEATLVSQQKLQAEAQERLKKEERRHAEAKDQ 451
E EQ+L+ K + +LQRELED + VS++ E ++ L + AE + +
Sbjct: 466 IKELEQSLLFEKTKADKLQRELEDTR----VATVSEKSRIMELEKDLALRVQEVAELRRR 521
Query: 452 LE 453
LE
Sbjct: 522 LE 523
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 71.2 bits (173), Expect = 2e-12
Identities = 101/476 (21%), Positives = 198/476 (41%), Gaps = 68/476 (14%)
Query: 74 LHKKIQLLEGDRKAFFESSQWNIKKNQETISQLRKETKALELKL-LDLLKGDEKVVQAVI 132
L ++ QL + + F E Q ++ ++ + + ++ K LE + L + D K + +
Sbjct: 1449 LEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQEL 1508
Query: 133 REWKWEKPYLKNRTGQALEHLDHRLREKVKQQNALRHQVVLRQRRLEELQLQHSLRLLEM 192
R + E+ +L+ Q L H R R+ ++++ LR Q +QRR + R E
Sbjct: 1509 RSQEPERKFLEEE--QQL-HRQQRQRKFLQEEQQLRRQERGQQRRQDR---DRKFREEEQ 1562
Query: 193 AEAQNRHTEVAKTMRNLENRLEKAQMKAQEAEH-ITSVYLQLKAYLMDESLNLENRLDSM 251
+ ++++ R+ + RLE+ +++ QE E QL+ + L E
Sbjct: 1563 LRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFR 1622
Query: 252 EAEVVRTKHELEALHVVNQEALNARDIAKNQLQYLEETLVRERKKRERYISECKKRAEEK 311
E E + + E + LH ++ + + + Q E+ L +R ++ R + + EE+
Sbjct: 1623 EDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQ 1682
Query: 312 KL----------ENERMERKTHREHLLLQSDDTIQ----DSLHAKEEELRQRWSMYQM-- 355
+L E E+ R+ RE LQ + ++ + +EE+LRQ Q+
Sbjct: 1683 QLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRR 1742
Query: 356 -------------------EVIFGKVKDATGTDETHSLVRRFLAQ------GDTFAQLET 390
+ + + +D +E R Q F + E
Sbjct: 1743 QERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQ 1802
Query: 391 LKSENEQTLVRLKQ-------EKQQLQ--------RELEDLKYSGEATLVSQQKLQAEAQ 435
L+ E E+ +R +Q E++QLQ R+ D +Y E +Q+K + E Q
Sbjct: 1803 LRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQ 1862
Query: 436 ERLKKEERRHAEAKDQLERALRAMQVAKDSLEHLASKLI-HITVEDGRFAGKELDP 490
E ++EE++ + + ER LR + + E + + I ++G+ G+ L+P
Sbjct: 1863 ELWQEEEQKR---RQERERKLREEHIRRQQKEEQRHRQVGEIKSQEGKGHGRLLEP 1915
Score = 69.3 bits (168), Expect = 9e-12
Identities = 108/531 (20%), Positives = 214/531 (40%), Gaps = 36/531 (6%)
Query: 76 KKIQLLEGDRKAFFESSQWNIKKNQETISQLRKETKALELKLLDLLKGDEKVVQAVI--- 132
++ +LLE RK E Q ++ Q+ + Q +E K + L K +EK+ +
Sbjct: 211 RRRELLELRRKGREEKQQQR-RERQDRVFQ-EEEEKEWRKRETVLRKEEEKLQEEEPQRQ 268
Query: 133 REWKWEKPYLKNRTGQALEHLDHRLREKVKQQNALRHQVVLRQRRLEELQLQHSLRLLEM 192
RE + E+ L+ Q L +E+ +QQ LR + LR+++ EE + Q R +
Sbjct: 269 RELQEEEEQLRKLERQELRR---ERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQ 325
Query: 193 AEAQNRHTEVAKTMRNLENRLEKAQMKAQEAEHITSVYLQLKAYLMDESLNLENRLDSME 252
+ + + +R + + Q++ ++ E L+ + L
Sbjct: 326 ERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRR 385
Query: 253 AEVVRTKHELEALHVVNQEA-LNARDIAKNQLQYLEETLVRERKKRERYISECKKRAEEK 311
+ +R + +L + +E L + + Q E +R ++ ER+ + ++ E+
Sbjct: 386 EQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQ 445
Query: 312 KLENERMER----KTHREHLLLQSDDTIQDSLHAKEEELRQRWSMYQMEVIFGKVKDATG 367
+L+ E+ ER K E + + Q +EEE R+RW K+++
Sbjct: 446 RLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWL---------KLEEEER 496
Query: 368 TDETHSLVRRFLAQGDTFAQLETLKSENEQTLVRLKQEKQQLQRELEDLKYSGEATLVSQ 427
++ ++ + + + + E E+ L + + +QQL+RE E+ + +
Sbjct: 497 REQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEK 556
Query: 428 QKLQAEAQERLKKEERRHAEAKDQLERALRAMQVAKDSLEHLASKLIHITVEDGRFAGKE 487
+ Q ++RLK+E+ + + E R ++ ++ E L +L VE R +E
Sbjct: 557 RLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVE--RLEQEE 614
Query: 488 LDPQADNYVPNLLGLVEEKLLKLQAQLQGHDVQEMLCHIANREFLASLEGRL--PEYNTR 545
Q L E + + Q L+ + +E RE E RL E R
Sbjct: 615 RREQR-------LKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEER 667
Query: 546 IALPLATSKDKFFDEESEEEDNEVVTRASLKIRSQK---LIESHKKHRRSR 593
+ L ++ E+ E+ + R +K R K +ES R+S+
Sbjct: 668 LEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSK 718
Score = 66.2 bits (160), Expect = 8e-11
Identities = 112/535 (20%), Positives = 214/535 (40%), Gaps = 56/535 (10%)
Query: 97 KKNQETISQLRKETKALELKLLDLLKGDEKVVQAVIREWKWE----------KPYLKNRT 146
K+ QE Q R+E + K + ++ Q +W+WE K Y K R
Sbjct: 1190 KRRQERERQYREEEELQRQKRKQRYRDED---QRSDLKWQWEPEKENAVRDNKVYCKGRE 1246
Query: 147 GQALEHL-DHRLREKVKQQNALRHQVVLRQRRLEELQL------------QHSLRLLEMA 193
+ L D +LR++ QQ+ L+H + +Q R E + + L E
Sbjct: 1247 NEQFRQLEDSQLRDRQSQQD-LQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQK 1305
Query: 194 EAQNRHTEVAKTMRNLENRLEKAQMKAQEAEHITSVYLQLKAYLMDESLNLENRLDSMEA 253
EA+ R + + + L E+ + + QE + QL ++ L + R
Sbjct: 1306 EAKRRDRKSQEEKQLLREEREEKRRR-QETDRKFREEEQLLQEREEQPLRRQERDRKFRE 1364
Query: 254 EVVRTKHELEALHVVNQEA-LNARDIAKNQLQYLEETLVRERKKRERYISECKKRAEEKK 312
E +R H+ + + +E L ++ + L+ ++ +ER+++ R + K R EE++
Sbjct: 1365 EELR--HQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQ 1422
Query: 313 L----------ENERMERKTHREHLLLQSDDTIQDSLHAKEEELRQRWSMYQMEVIFGKV 362
L E E+ R+ RE L+ + ++ H K E Q + + + +
Sbjct: 1423 LSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQE 1482
Query: 363 KDATGTDETHSLVRRFLAQGDTFAQLETLKSENEQTLVRLKQEKQQLQRELEDLKYSGEA 422
+D +E L R+ + F + E E E+ + +E+QQL R+ K+ E
Sbjct: 1483 RDRKFLEEEQQLRRQ--ERDRKFREQELRSQEPER---KFLEEEQQLHRQQRQRKFLQEE 1537
Query: 423 TLVSQQKLQAEAQERLKKEERRHAEAKDQLERALRAMQVA---KDSLEHLASKLIHITVE 479
Q + Q Q+R + +R+ E ++QL + Q++ +D L + + +
Sbjct: 1538 ---QQLRRQERGQQRRQDRDRKFRE-EEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQ 1593
Query: 480 DGRFAGKELDPQADNYVPNLLGLVEEKLLKLQAQLQGHDVQEMLCHIANREFLASLEGRL 539
+ +F E + L + K + + LQ + Q++ +R+FL E +L
Sbjct: 1594 ERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEE-EPQL 1652
Query: 540 PEYNTRIALPLATSKDKFFDEESEEEDNEVVTRASLKIRSQKLIESHKKHRRSRR 594
L +D+ F EE + + + R +K E ++ RR R
Sbjct: 1653 RRQERE--QQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQER 1705
Score = 60.8 bits (146), Expect = 3e-09
Identities = 110/543 (20%), Positives = 224/543 (41%), Gaps = 45/543 (8%)
Query: 79 QLLEGDRKAFFES--SQWNIKKNQETISQLRKETKALELKLLDLLKGDEKVVQAVIREWK 136
+L EG+ ++ + Q + ++ E + + R+E + E + + +E+ +Q+
Sbjct: 147 ELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREER-----RAEEEQLQSCKGHET 201
Query: 137 WEKPYLKNRTGQALEHLDHRLREKVKQQNALRHQVVLRQRRLEELQLQHSLRLLEMAEAQ 196
E P + + L L + RE+ +QQ R V ++ +E + + ++ E + Q
Sbjct: 202 EEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQ 261
Query: 197 NRHTEVAKTMRNLENRLEKAQMKAQEAEHITSVYLQLKAYLMDESLNLENRLDSMEAEVV 256
+ + ++ E +L K + + E Q + L E +L + E
Sbjct: 262 EEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQ-------QRLRREQQLRRKQEEER 314
Query: 257 RTKHE---LEALHVVNQEALNARDIAKNQLQYLEETLVRERKKRERYISECKKRAEEKKL 313
R + E + QE + + + Q + E+ L RE+++ R +++ EE++
Sbjct: 315 REQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERRE 374
Query: 314 ENERMERKTHREHLLLQSDDTIQDSLHAKEEELR-----QRWSMYQMEVIFGKVKDATGT 368
+ R E++ RE L + ++ +E++LR +R + E + ++
Sbjct: 375 QQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERH 434
Query: 369 DETHSLVRR-FLAQGDTFAQLETLKSENEQTLVRLKQEKQQLQRELED------LKYSGE 421
++ H RR + + + + LK E E ++ KQQL+R+ E+ LK E
Sbjct: 435 EQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEE 494
Query: 422 ATLVSQQKLQAEAQERLKKEERR-----HAEAKDQLERALRAMQVAKDSLEHLASKLIHI 476
+Q+ + E Q R ++EERR E +++L++ LR+ Q + E +L+
Sbjct: 495 ER--REQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKR 552
Query: 477 TVE---DGRFAGKELDPQADNYVPNLLGLVEEKLLKLQAQLQGHDVQEMLCHIANREFLA 533
E + + L + + LL EE+ + Q + +E L RE +
Sbjct: 553 EEEKRLEQERREQRLKREQEERRDQLLKREEER----RQQRLKREQEERLEQRLKREEVE 608
Query: 534 SLE-GRLPEYNTRIALPLATSKDKFF-DEESEEEDNEVVTRASLKIRSQKLIESHKKHRR 591
LE E + P + + EE EE + + R + R Q+L ++ R
Sbjct: 609 RLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERL 668
Query: 592 SRR 594
+R
Sbjct: 669 EQR 671
Score = 58.9 bits (141), Expect = 1e-08
Identities = 79/338 (23%), Positives = 150/338 (44%), Gaps = 20/338 (5%)
Query: 134 EWKWEKPYLKNRTGQALEHLDHRLREKVKQQNAL-RHQVVLRQRRL----EELQLQHSLR 188
E + E+ + + R Q L+ R+ +K++ RH+ R+++L EE + + L+
Sbjct: 431 EERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLK 490
Query: 189 LLEMAEAQNRHTEVAKTMRNLENRLEKAQMKAQEAEHITSVYLQLKAYLMDESLNLENRL 248
L E + + + R E R E+ ++K QE E L+ + L E +L
Sbjct: 491 LEEEERREQQERREQQLRREQEERREQ-RLKRQEEEERLQQRLRSEQQLRREQEERREQL 549
Query: 249 DSMEAEVVRTKHELEALHVVNQEALNARDIAKNQLQYLEETLVRERKKRERYISECKKRA 308
E E R + E + ++ + K + + ++ L RE+++R + + KR
Sbjct: 550 LKREEEK-RLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEER---LEQRLKRE 605
Query: 309 EEKKLENE-RMERKTHREHLLLQSDDTIQDSLHAKEEELRQRWSMYQMEVIFGKVKDATG 367
E ++LE E R E++ RE + ++ + L EE+ +R + E + +
Sbjct: 606 EVERLEQEERREQRLKRE----EPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKR 661
Query: 368 TDETHSLVRRFLAQGDTFAQLETL-KSENEQTLVRLKQEKQQLQRELE---DLKYSGEAT 423
+E L +R + + + + L + E EQ R+K + Q +LE D + S +
Sbjct: 662 EEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYS 721
Query: 424 LVSQQKLQAEAQERLKKEERRHAEAK-DQLERALRAMQ 460
+Q+ Q QE+ +K RR +E + + ERA R Q
Sbjct: 722 RPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQ 759
Score = 58.5 bits (140), Expect = 2e-08
Identities = 92/396 (23%), Positives = 150/396 (37%), Gaps = 72/396 (18%)
Query: 135 WKWEKPYLKNRTGQAL-------EHLDHRLREKVKQQNALRH-------QVVLRQRRL-- 178
W+W+ R Q L E + +LR + +QQ R + RQRR
Sbjct: 769 WQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRRERE 828
Query: 179 -------EELQLQHSLRLLEMAEAQNRHTEVAKTMRNLENRLEKAQMKAQEAEHITSVYL 231
EE QLQ R ++ E ++ E + R+ E R ++ E E +
Sbjct: 829 KELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHT 888
Query: 232 QLKAYLMDESLNLENRLDSMEAEVVRTKHELEALHVVNQEALNARDIAKNQLQYLEETLV 291
+ E L E +L E E ++ + E E QE + QLQ EE L+
Sbjct: 889 LYAKPALQEQLRKEQQLLQEEEEELQ-REEREKRRRQEQERQYREE---EQLQQEEEQLL 944
Query: 292 RERKKRERYISECKKRAEEKKLENE-------------RMER-KTHREHLLLQSDDTIQD 337
RE +++ R ++ ++KKL+ + R ER K +RE LQ ++ Q
Sbjct: 945 REEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEE-QL 1003
Query: 338 SLHAKEEELRQRWSMYQMEVIFGKVKDATGTDETHSL-----VRRFLAQGDTFAQLETLK 392
+E+ RQ W + KD +E L RR + + + E L+
Sbjct: 1004 LREEREKRRRQEWERQYRK------KDELQQEEEQLLREEREKRRLQERERQYREEEELQ 1057
Query: 393 SENEQTL-------------------VRLKQEKQQLQRELEDLKYSGEATLVSQQKLQAE 433
E EQ L L+QE++QL RE + + E +++ + +
Sbjct: 1058 QEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQ 1117
Query: 434 AQERLKKEERRHAEAKDQLERALRAMQVAKDSLEHL 469
+E E R + +LER R + + E L
Sbjct: 1118 QEEEQLLREEREKRRRQELERQYREEEEVQQEEEQL 1153
Score = 58.2 bits (139), Expect = 2e-08
Identities = 121/583 (20%), Positives = 222/583 (38%), Gaps = 72/583 (12%)
Query: 59 HRGAGKPSVHSQVAELHKKIQLLEGDRKAFFESSQWNIKKNQETISQLRKETKALELKLL 118
H KP++ Q L K+ QLL+ + + + + ++ QE Q R+E + L+ +
Sbjct: 887 HTLYAKPALQEQ---LRKEQQLLQEEEEEL-QREEREKRRRQEQERQYREEEQ-LQQEEE 941
Query: 119 DLLKGDEKVVQAVIREWKWEKPYLKNRTGQALEHLDHRLREKVKQQNALRHQVVLRQRRL 178
LL+ + + + RE ++ K + + L + R + +++ R + L+Q
Sbjct: 942 QLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEE 1001
Query: 179 EELQLQHSLRLLEMAEAQNRHTEVAKTMRNLENRLEKAQMKAQEAEHITSVYLQLKAYLM 238
+ L+ + R + E Q R + + R E+ + + QE E + Y
Sbjct: 1002 QLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERE---------RQYRE 1052
Query: 239 DESLNLENRLDSMEAEVVRTKHELEALHVVNQEALNARDIA------------------- 279
+E L E E R + ELE + +E +
Sbjct: 1053 EEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCRE 1112
Query: 280 KNQLQYLEETLVRE-RKKRERYISECKKRAEEK--------------KLENERMERKTHR 324
+ +LQ EE L+RE R+KR R E + R EE+ K + +ER+
Sbjct: 1113 EEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYRE 1172
Query: 325 EHLLLQSDDTIQDSLHAKEEELRQRWSMYQMEVIFGKVKDATGTDETHSLVRRFLAQGDT 384
E L Q ++ + K + R+R + E+ K K ++ S D
Sbjct: 1173 EEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRS---------DL 1223
Query: 385 FAQLETLKSEN-EQTLVRLKQEKQQLQRELEDLKYSGEATLVSQQKLQAEAQERLKKEER 443
Q E K V K + + R+LED + + Q L E QER +++ER
Sbjct: 1224 KWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQER 1283
Query: 444 -------RHAEAKDQLERALRAMQVAKDSLEHLASKLIHITVEDGRFAGKELDPQADNYV 496
RH ++QLER + +D +L+ E+ R ++ +
Sbjct: 1284 RRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKR--RRQETDRKFREE 1341
Query: 497 PNLLGLVEEKLLKLQAQLQGHDVQEMLCHIANREFLASLEGRLPEYNTRIALP-----LA 551
LL EE+ L+ Q + + +E+ R+FL + + R L
Sbjct: 1342 EQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRC 1401
Query: 552 TSKDKFFDEESEEEDNEVVTRASLKIRSQKLIESHKKHRRSRR 594
+++ ++ + + E + S + R +K E ++ RR R
Sbjct: 1402 QEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQER 1444
Score = 54.3 bits (129), Expect = 3e-07
Identities = 87/409 (21%), Positives = 161/409 (39%), Gaps = 45/409 (11%)
Query: 90 ESSQWNIKKNQETISQLRKETKALELKLLDLLKGDEKVVQAVIREWKWEKPYLKNRTGQA 149
E + +K+ QE K + E + K K Q R +W K
Sbjct: 441 ERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLK---------- 490
Query: 150 LEHLDHRLREKVKQQNALRHQVVLRQRRL----EELQLQHSLRLLEMAEAQNRHTEVAKT 205
LE + R +++ ++Q R Q R++RL EE +LQ LR + +
Sbjct: 491 LEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLL 550
Query: 206 MRNLENRLE---KAQMKAQEAEHITSVYLQLKAYLMDESLNLENRLDSMEAEVVRTKHEL 262
R E RLE + Q +E E L+ + + L E + +E + R + E
Sbjct: 551 KREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQE-ERLEQRLKREEVER 609
Query: 263 EALHVVNQEALNARDIAKNQLQYLEETLVRERKKRERYISECKKRAEEK---KLENERME 319
++ L + + + Q L ++ +E +++++ E ++R E++ + E ER+E
Sbjct: 610 LEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLE 669
Query: 320 RKTHREHLLLQSDDTIQDSLHAKEEELRQR-------WSMYQMEVIFGKVKDATGTDETH 372
++ REH + + Q+ ++E+ R+R W +
Sbjct: 670 QRLKREH---EEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQ 726
Query: 373 SLVRRFLAQGDTFAQLET-LKSENEQTLVRLKQEKQQLQ-----------RELEDLKYSG 420
RR Q + + E+ L+ + E+ R +QE++Q + E + S
Sbjct: 727 EGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSA 786
Query: 421 EATLVSQQKLQAEAQERLKKEER--RHAEAKDQLERALRAMQVAKDSLE 467
L Q++ Q A+ER ++E+R E K+Q R R + LE
Sbjct: 787 RPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLE 835
>gi|156766068 CDC42 binding protein kinase gamma (DMPK-like) [Homo
sapiens]
Length = 1551
Score = 70.9 bits (172), Expect = 3e-12
Identities = 100/432 (23%), Positives = 168/432 (38%), Gaps = 41/432 (9%)
Query: 55 GGSFHRGAGKPSVHSQV-AELHKKIQLLEGDRKAFFESSQ--WNIKKNQETISQLRKETK 111
G ++ G+ P S+ A L +K+Q LE ++ Q + + + QLRKE +
Sbjct: 395 GFTYTSGSHSPESSSEAWAALERKLQCLEQEKVELSRKHQEALHAPTDHRELEQLRKEVQ 454
Query: 112 ALELKLLDLLKGDEKVVQAVIREWKWEKPYLKNRTGQALEHLDHRLREKVKQQNALRHQV 171
L +L ++L+ + Q P + Q L+ L L E A ++
Sbjct: 455 TLRDRLPEMLRDKASLSQT--DGPPAGSPGQDSDLRQELDRLHRELAEGRAGLQAQEQEL 512
Query: 172 VLRQRRLEELQLQHSLRLLEMAEAQNRHTEVAKTMRNLENRLEKAQMKAQEAEHITSVYL 231
Q + EEL L + EAQ R A R L ++LE+A+ +E E S
Sbjct: 513 CRAQGQQEEL-------LQRLQEAQEREAATASQTRALSSQLEEARAAQRELEAQVSSLS 565
Query: 232 QLKAYLMDESLNLENRLD-SMEAEVVRTKHELEALHVVN---QEALNARDIAKNQLQYLE 287
+ L + E RL+ S +A+ + T E + QEA +++A L
Sbjct: 566 RQVTQLQGQ---WEQRLEESSQAKTIHTASETNGMGPPEGGPQEAQLRKEVAA-----LR 617
Query: 288 ETLVRERKKRERYISECKKRAEEKKLENERMERKTHREHLLLQSDDTIQDSLHAKEEELR 347
E L + R E + +E EN R+ R+ R L + + L + E
Sbjct: 618 EQLEQAHSHRPSGKEEALCQLQE---ENRRLSREQERLEAELAQEQESKQRLEGERRETE 674
Query: 348 QRWSMYQMEVIFGKVKDATGTDETHSLVRRFLAQGDTFAQLETLKSENEQTLVRLKQEKQ 407
W +++ + +L + + LE+L++ QTL + Q
Sbjct: 675 SNWEAQLADILSWVNDEKVSRGYLQALATKMAEE------LESLRNVGTQTLPARPLDHQ 728
Query: 408 QLQRELEDLKYSGEATLVSQQKLQAE------AQERLKKEERRHAEAKDQLERALRAMQV 461
R L+ K A L Q L+AE QERL + + +A+ +L+ A + Q
Sbjct: 729 WKARRLQ--KMEASARLELQSALEAEIRAKQGLQERLTQVQEAQLQAERRLQEAEKQSQA 786
Query: 462 AKDSLEHLASKL 473
+ L L +L
Sbjct: 787 LQQELAMLREEL 798
>gi|217272804 hyaluronan-mediated motility receptor isoform d [Homo
sapiens]
Length = 638
Score = 69.7 bits (169), Expect = 7e-12
Identities = 119/506 (23%), Positives = 228/506 (45%), Gaps = 50/506 (9%)
Query: 92 SQWNIKKNQETISQLRKETKALELKLLDLLKGDEKVVQAV--IREWKWEKPYLKNRTGQA 149
+Q +++++Q I+QL + ++E + +D EK+++ + I + K Q
Sbjct: 112 TQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQL 171
Query: 150 LEHLDHRLREKVKQQNALRHQVVLRQRRLEELQLQHSLRLLEMAEAQNRHTEVAKTMR-N 208
E+L + E + + +L +V+ +++E+L ++ L E + NR+ E + +
Sbjct: 172 EENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAE 231
Query: 209 LENRLEKAQMKAQEAEHITSVYLQLKAYLMDE---SLNLENRLDSMEAEVVRTKHELEAL 265
++N +K ++ QE E + LQ+ + L E S +L +L S + E+V+ K+ E
Sbjct: 232 MQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFE-- 289
Query: 266 HVVNQEALNARDIAKNQLQYLEETLVRERKKRERYISECKKRAEEKKLENERMERKTHRE 325
E L ++LQ EE R K+ E E K RAEE KL E+++ K
Sbjct: 290 -----EELKQTLDELDKLQQKEEQAERLVKQLE---EEAKSRAEELKLLEEKLKGK--EA 339
Query: 326 HLLLQSDDTIQDSLHAKEEELRQRWSMYQMEVIFGKVKDATGTD------ETHSLVRRFL 379
L S Q +L +E+ S+ + F K T ++ E SL +
Sbjct: 340 ELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAA 399
Query: 380 AQG----DTFAQLETLKSENEQ---TLVRLKQEKQQLQRELEDLKYS---GEATLVSQQK 429
G D Q+ +S N++ L+ L+ + + E++++ S L +Q K
Sbjct: 400 KAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLK 459
Query: 430 LQAE-AQERLKKEERRHAEAKDQLERALRAMQVAKDSLEHLASKLIHITVEDGRFAGKEL 488
Q E +++L+ EE R AE ++ + + E L +K ++ F E+
Sbjct: 460 QQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAF---EV 516
Query: 489 DPQADNYVPNLLGLVEEKLLKLQ---AQLQGH-DVQEMLCHIANREFLASLEGRLPEYNT 544
+ QA + N G +E+L K++ A+L GH ++++ + H+ L +L +
Sbjct: 517 EKQA---LLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVK---LKDENSQLKSEVS 570
Query: 545 RIALPLATSKDKFFDEESEEEDNEVV 570
++ LA K K + + +EE N+V+
Sbjct: 571 KLRCQLA--KKKQSETKLQEELNKVL 594
Score = 59.3 bits (142), Expect = 1e-08
Identities = 94/404 (23%), Positives = 181/404 (44%), Gaps = 43/404 (10%)
Query: 70 QVAELHKKIQLLEGDRKAF----------FESSQWNIKKNQETISQLRKETKALELKLLD 119
QV +L+ K QLLE +++ + N+K+ Q R++ + EL++
Sbjct: 199 QVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDS 258
Query: 120 LLKGDEKVVQAVIR-------EWKWEKPYLKNRTGQALEHLDHRLREKVKQQNALRHQVV 172
LL+ ++++ ++ + E EK + Q L+ LD +L++K +Q L Q+
Sbjct: 259 LLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELD-KLQQKEEQAERLVKQLE 317
Query: 173 LRQR-RLEELQLQHSLRLLEMAEAQNRHTEVAKTMRNLENRLEKAQMKAQEAEHITSVYL 231
+ R EEL+L L+ EA+ + A T L + EK Q E +T+ +
Sbjct: 318 EEAKSRAEELKLLEEK--LKGKEAELEKSSAAHTQATLLLQ-EKYDSMVQSLEDVTAQFE 374
Query: 232 QLKAYLMDESLNLENRLDSMEAEVVRT-------KHELEALHVVNQEALNARDIAKNQLQ 284
KA E +L+ S++ + + +H++ A NQE + +
Sbjct: 375 SYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRML-LDLQTKS 433
Query: 285 YLEETLVRE-----RKKRERYISECKKRAEE--KKLENERMERKTHREHLLLQSDDTIQD 337
L+ET ++E +K ++ K++ E+ K+LE+E RK +E+ + + I +
Sbjct: 434 ALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEE-GRKAEKENTTAELTEEI-N 491
Query: 338 SLHAKEEELRQRWSMYQMEVIFGKVKDATGTDETHSLVRRFLAQGDTFAQL---ETLKSE 394
EEL + +Q+++ +V+ +E + + D++A+L + LK +
Sbjct: 492 KWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQK 551
Query: 395 NEQTLVRLKQEKQQLQRELEDLKYSGEATLVSQQKLQAEAQERL 438
+ +V+LK E QL+ E+ L+ S+ KLQ E + L
Sbjct: 552 IKH-VVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEELNKVL 594
>gi|217272802 hyaluronan-mediated motility receptor isoform a [Homo
sapiens]
Length = 725
Score = 69.7 bits (169), Expect = 7e-12
Identities = 119/506 (23%), Positives = 228/506 (45%), Gaps = 50/506 (9%)
Query: 92 SQWNIKKNQETISQLRKETKALELKLLDLLKGDEKVVQAV--IREWKWEKPYLKNRTGQA 149
+Q +++++Q I+QL + ++E + +D EK+++ + I + K Q
Sbjct: 199 TQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQL 258
Query: 150 LEHLDHRLREKVKQQNALRHQVVLRQRRLEELQLQHSLRLLEMAEAQNRHTEVAKTMR-N 208
E+L + E + + +L +V+ +++E+L ++ L E + NR+ E + +
Sbjct: 259 EENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAE 318
Query: 209 LENRLEKAQMKAQEAEHITSVYLQLKAYLMDE---SLNLENRLDSMEAEVVRTKHELEAL 265
++N +K ++ QE E + LQ+ + L E S +L +L S + E+V+ K+ E
Sbjct: 319 MQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFE-- 376
Query: 266 HVVNQEALNARDIAKNQLQYLEETLVRERKKRERYISECKKRAEEKKLENERMERKTHRE 325
E L ++LQ EE R K+ E E K RAEE KL E+++ K
Sbjct: 377 -----EELKQTLDELDKLQQKEEQAERLVKQLE---EEAKSRAEELKLLEEKLKGK--EA 426
Query: 326 HLLLQSDDTIQDSLHAKEEELRQRWSMYQMEVIFGKVKDATGTD------ETHSLVRRFL 379
L S Q +L +E+ S+ + F K T ++ E SL +
Sbjct: 427 ELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAA 486
Query: 380 AQG----DTFAQLETLKSENEQ---TLVRLKQEKQQLQRELEDLKYS---GEATLVSQQK 429
G D Q+ +S N++ L+ L+ + + E++++ S L +Q K
Sbjct: 487 KAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLK 546
Query: 430 LQAE-AQERLKKEERRHAEAKDQLERALRAMQVAKDSLEHLASKLIHITVEDGRFAGKEL 488
Q E +++L+ EE R AE ++ + + E L +K ++ F E+
Sbjct: 547 QQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAF---EV 603
Query: 489 DPQADNYVPNLLGLVEEKLLKLQ---AQLQGH-DVQEMLCHIANREFLASLEGRLPEYNT 544
+ QA + N G +E+L K++ A+L GH ++++ + H+ L +L +
Sbjct: 604 EKQA---LLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVK---LKDENSQLKSEVS 657
Query: 545 RIALPLATSKDKFFDEESEEEDNEVV 570
++ LA K K + + +EE N+V+
Sbjct: 658 KLRCQLA--KKKQSETKLQEELNKVL 681
Score = 59.3 bits (142), Expect = 1e-08
Identities = 94/404 (23%), Positives = 181/404 (44%), Gaps = 43/404 (10%)
Query: 70 QVAELHKKIQLLEGDRKAF----------FESSQWNIKKNQETISQLRKETKALELKLLD 119
QV +L+ K QLLE +++ + N+K+ Q R++ + EL++
Sbjct: 286 QVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDS 345
Query: 120 LLKGDEKVVQAVIR-------EWKWEKPYLKNRTGQALEHLDHRLREKVKQQNALRHQVV 172
LL+ ++++ ++ + E EK + Q L+ LD +L++K +Q L Q+
Sbjct: 346 LLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELD-KLQQKEEQAERLVKQLE 404
Query: 173 LRQR-RLEELQLQHSLRLLEMAEAQNRHTEVAKTMRNLENRLEKAQMKAQEAEHITSVYL 231
+ R EEL+L L+ EA+ + A T L + EK Q E +T+ +
Sbjct: 405 EEAKSRAEELKLLEEK--LKGKEAELEKSSAAHTQATLLLQ-EKYDSMVQSLEDVTAQFE 461
Query: 232 QLKAYLMDESLNLENRLDSMEAEVVRT-------KHELEALHVVNQEALNARDIAKNQLQ 284
KA E +L+ S++ + + +H++ A NQE + +
Sbjct: 462 SYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRML-LDLQTKS 520
Query: 285 YLEETLVRE-----RKKRERYISECKKRAEE--KKLENERMERKTHREHLLLQSDDTIQD 337
L+ET ++E +K ++ K++ E+ K+LE+E RK +E+ + + I +
Sbjct: 521 ALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEE-GRKAEKENTTAELTEEI-N 578
Query: 338 SLHAKEEELRQRWSMYQMEVIFGKVKDATGTDETHSLVRRFLAQGDTFAQL---ETLKSE 394
EEL + +Q+++ +V+ +E + + D++A+L + LK +
Sbjct: 579 KWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQK 638
Query: 395 NEQTLVRLKQEKQQLQRELEDLKYSGEATLVSQQKLQAEAQERL 438
+ +V+LK E QL+ E+ L+ S+ KLQ E + L
Sbjct: 639 IKH-VVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEELNKVL 681
>gi|217416398 hyaluronan-mediated motility receptor isoform c [Homo
sapiens]
Length = 709
Score = 69.7 bits (169), Expect = 7e-12
Identities = 119/506 (23%), Positives = 228/506 (45%), Gaps = 50/506 (9%)
Query: 92 SQWNIKKNQETISQLRKETKALELKLLDLLKGDEKVVQAV--IREWKWEKPYLKNRTGQA 149
+Q +++++Q I+QL + ++E + +D EK+++ + I + K Q
Sbjct: 183 TQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQL 242
Query: 150 LEHLDHRLREKVKQQNALRHQVVLRQRRLEELQLQHSLRLLEMAEAQNRHTEVAKTMR-N 208
E+L + E + + +L +V+ +++E+L ++ L E + NR+ E + +
Sbjct: 243 EENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAE 302
Query: 209 LENRLEKAQMKAQEAEHITSVYLQLKAYLMDE---SLNLENRLDSMEAEVVRTKHELEAL 265
++N +K ++ QE E + LQ+ + L E S +L +L S + E+V+ K+ E
Sbjct: 303 MQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFE-- 360
Query: 266 HVVNQEALNARDIAKNQLQYLEETLVRERKKRERYISECKKRAEEKKLENERMERKTHRE 325
E L ++LQ EE R K+ E E K RAEE KL E+++ K
Sbjct: 361 -----EELKQTLDELDKLQQKEEQAERLVKQLE---EEAKSRAEELKLLEEKLKGK--EA 410
Query: 326 HLLLQSDDTIQDSLHAKEEELRQRWSMYQMEVIFGKVKDATGTD------ETHSLVRRFL 379
L S Q +L +E+ S+ + F K T ++ E SL +
Sbjct: 411 ELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAA 470
Query: 380 AQG----DTFAQLETLKSENEQ---TLVRLKQEKQQLQRELEDLKYS---GEATLVSQQK 429
G D Q+ +S N++ L+ L+ + + E++++ S L +Q K
Sbjct: 471 KAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLK 530
Query: 430 LQAE-AQERLKKEERRHAEAKDQLERALRAMQVAKDSLEHLASKLIHITVEDGRFAGKEL 488
Q E +++L+ EE R AE ++ + + E L +K ++ F E+
Sbjct: 531 QQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAF---EV 587
Query: 489 DPQADNYVPNLLGLVEEKLLKLQ---AQLQGH-DVQEMLCHIANREFLASLEGRLPEYNT 544
+ QA + N G +E+L K++ A+L GH ++++ + H+ L +L +
Sbjct: 588 EKQA---LLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVK---LKDENSQLKSEVS 641
Query: 545 RIALPLATSKDKFFDEESEEEDNEVV 570
++ LA K K + + +EE N+V+
Sbjct: 642 KLRCQLA--KKKQSETKLQEELNKVL 665
Score = 59.3 bits (142), Expect = 1e-08
Identities = 94/404 (23%), Positives = 181/404 (44%), Gaps = 43/404 (10%)
Query: 70 QVAELHKKIQLLEGDRKAF----------FESSQWNIKKNQETISQLRKETKALELKLLD 119
QV +L+ K QLLE +++ + N+K+ Q R++ + EL++
Sbjct: 270 QVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDS 329
Query: 120 LLKGDEKVVQAVIR-------EWKWEKPYLKNRTGQALEHLDHRLREKVKQQNALRHQVV 172
LL+ ++++ ++ + E EK + Q L+ LD +L++K +Q L Q+
Sbjct: 330 LLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELD-KLQQKEEQAERLVKQLE 388
Query: 173 LRQR-RLEELQLQHSLRLLEMAEAQNRHTEVAKTMRNLENRLEKAQMKAQEAEHITSVYL 231
+ R EEL+L L+ EA+ + A T L + EK Q E +T+ +
Sbjct: 389 EEAKSRAEELKLLEEK--LKGKEAELEKSSAAHTQATLLLQ-EKYDSMVQSLEDVTAQFE 445
Query: 232 QLKAYLMDESLNLENRLDSMEAEVVRT-------KHELEALHVVNQEALNARDIAKNQLQ 284
KA E +L+ S++ + + +H++ A NQE + +
Sbjct: 446 SYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRML-LDLQTKS 504
Query: 285 YLEETLVRE-----RKKRERYISECKKRAEE--KKLENERMERKTHREHLLLQSDDTIQD 337
L+ET ++E +K ++ K++ E+ K+LE+E RK +E+ + + I +
Sbjct: 505 ALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEE-GRKAEKENTTAELTEEI-N 562
Query: 338 SLHAKEEELRQRWSMYQMEVIFGKVKDATGTDETHSLVRRFLAQGDTFAQL---ETLKSE 394
EEL + +Q+++ +V+ +E + + D++A+L + LK +
Sbjct: 563 KWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQK 622
Query: 395 NEQTLVRLKQEKQQLQRELEDLKYSGEATLVSQQKLQAEAQERL 438
+ +V+LK E QL+ E+ L+ S+ KLQ E + L
Sbjct: 623 IKH-VVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEELNKVL 665
>gi|217416394 hyaluronan-mediated motility receptor isoform b [Homo
sapiens]
Length = 724
Score = 69.7 bits (169), Expect = 7e-12
Identities = 119/506 (23%), Positives = 228/506 (45%), Gaps = 50/506 (9%)
Query: 92 SQWNIKKNQETISQLRKETKALELKLLDLLKGDEKVVQAV--IREWKWEKPYLKNRTGQA 149
+Q +++++Q I+QL + ++E + +D EK+++ + I + K Q
Sbjct: 198 TQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQL 257
Query: 150 LEHLDHRLREKVKQQNALRHQVVLRQRRLEELQLQHSLRLLEMAEAQNRHTEVAKTMR-N 208
E+L + E + + +L +V+ +++E+L ++ L E + NR+ E + +
Sbjct: 258 EENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAE 317
Query: 209 LENRLEKAQMKAQEAEHITSVYLQLKAYLMDE---SLNLENRLDSMEAEVVRTKHELEAL 265
++N +K ++ QE E + LQ+ + L E S +L +L S + E+V+ K+ E
Sbjct: 318 MQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFE-- 375
Query: 266 HVVNQEALNARDIAKNQLQYLEETLVRERKKRERYISECKKRAEEKKLENERMERKTHRE 325
E L ++LQ EE R K+ E E K RAEE KL E+++ K
Sbjct: 376 -----EELKQTLDELDKLQQKEEQAERLVKQLE---EEAKSRAEELKLLEEKLKGK--EA 425
Query: 326 HLLLQSDDTIQDSLHAKEEELRQRWSMYQMEVIFGKVKDATGTD------ETHSLVRRFL 379
L S Q +L +E+ S+ + F K T ++ E SL +
Sbjct: 426 ELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAA 485
Query: 380 AQG----DTFAQLETLKSENEQ---TLVRLKQEKQQLQRELEDLKYS---GEATLVSQQK 429
G D Q+ +S N++ L+ L+ + + E++++ S L +Q K
Sbjct: 486 KAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLK 545
Query: 430 LQAE-AQERLKKEERRHAEAKDQLERALRAMQVAKDSLEHLASKLIHITVEDGRFAGKEL 488
Q E +++L+ EE R AE ++ + + E L +K ++ F E+
Sbjct: 546 QQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAF---EV 602
Query: 489 DPQADNYVPNLLGLVEEKLLKLQ---AQLQGH-DVQEMLCHIANREFLASLEGRLPEYNT 544
+ QA + N G +E+L K++ A+L GH ++++ + H+ L +L +
Sbjct: 603 EKQA---LLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVK---LKDENSQLKSEVS 656
Query: 545 RIALPLATSKDKFFDEESEEEDNEVV 570
++ LA K K + + +EE N+V+
Sbjct: 657 KLRCQLA--KKKQSETKLQEELNKVL 680
Score = 59.3 bits (142), Expect = 1e-08
Identities = 94/404 (23%), Positives = 181/404 (44%), Gaps = 43/404 (10%)
Query: 70 QVAELHKKIQLLEGDRKAF----------FESSQWNIKKNQETISQLRKETKALELKLLD 119
QV +L+ K QLLE +++ + N+K+ Q R++ + EL++
Sbjct: 285 QVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDS 344
Query: 120 LLKGDEKVVQAVIR-------EWKWEKPYLKNRTGQALEHLDHRLREKVKQQNALRHQVV 172
LL+ ++++ ++ + E EK + Q L+ LD +L++K +Q L Q+
Sbjct: 345 LLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELD-KLQQKEEQAERLVKQLE 403
Query: 173 LRQR-RLEELQLQHSLRLLEMAEAQNRHTEVAKTMRNLENRLEKAQMKAQEAEHITSVYL 231
+ R EEL+L L+ EA+ + A T L + EK Q E +T+ +
Sbjct: 404 EEAKSRAEELKLLEEK--LKGKEAELEKSSAAHTQATLLLQ-EKYDSMVQSLEDVTAQFE 460
Query: 232 QLKAYLMDESLNLENRLDSMEAEVVRT-------KHELEALHVVNQEALNARDIAKNQLQ 284
KA E +L+ S++ + + +H++ A NQE + +
Sbjct: 461 SYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRML-LDLQTKS 519
Query: 285 YLEETLVRE-----RKKRERYISECKKRAEE--KKLENERMERKTHREHLLLQSDDTIQD 337
L+ET ++E +K ++ K++ E+ K+LE+E RK +E+ + + I +
Sbjct: 520 ALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEE-GRKAEKENTTAELTEEI-N 577
Query: 338 SLHAKEEELRQRWSMYQMEVIFGKVKDATGTDETHSLVRRFLAQGDTFAQL---ETLKSE 394
EEL + +Q+++ +V+ +E + + D++A+L + LK +
Sbjct: 578 KWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQK 637
Query: 395 NEQTLVRLKQEKQQLQRELEDLKYSGEATLVSQQKLQAEAQERL 438
+ +V+LK E QL+ E+ L+ S+ KLQ E + L
Sbjct: 638 IKH-VVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEELNKVL 680
>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
sapiens]
Length = 1940
Score = 69.3 bits (168), Expect = 9e-12
Identities = 101/461 (21%), Positives = 191/461 (41%), Gaps = 72/461 (15%)
Query: 96 IKKNQETISQLRKETKALELKLLDLLKGDEKVVQAVIREWKWEKPYLKNRTGQALEHLDH 155
I +N +TI +L K K +EL+ D+ E+ +A + + + ++ Q +D
Sbjct: 1517 IAENGKTIHELEKSRKQIELEKADIQLALEEA-EAALEHEEAKILRIQLELTQVKSEIDR 1575
Query: 156 RLREKVKQQNALRHQVVLRQRRLEELQLQHSLRLLEMAEAQNRHTEVAKTMRNLENRLEK 215
++ EK ++ L+ QR +E +Q + EA ++ + +E +L
Sbjct: 1576 KIAEKDEEIEQLKRNY---QRTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSH 1632
Query: 216 AQMKAQEA-EHITSVYLQLKAYLMDESLNLENRLDSMEAEVVRTKHELEALHVVNQEALN 274
A +A E +H+ SV QLK D L+L++ L R + +L+ + + N
Sbjct: 1633 ANRQAAETLKHLRSVQGQLK----DTQLHLDDAL--------RGQEDLKEQLAIVERRAN 1680
Query: 275 ARDIAKNQLQYLEETLVRERKKRERYISECKKRAEEKKLENERM---ERKTHREHLLLQS 331
+L+ E R RK E+ + + +R + +N + ++K + + LQS
Sbjct: 1681 LLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQS 1740
Query: 332 D--DTIQDSLHAKEEELRQRWSMYQMEVIFGKVKDATGTDETHSLVRRFLAQGDTFAQLE 389
+ D +D+ +A+E+ + + DA + + DT A LE
Sbjct: 1741 EVEDASRDARNAEEKAKKA-------------ITDAA------MMAEELKKEQDTSAHLE 1781
Query: 390 TLKSENEQTL------------VRLKQEKQQLQRELEDLKYSGEATLVSQQKLQAEAQER 437
+K EQT+ + LK K+Q+Q+ LE E L +QK E+ +
Sbjct: 1782 RMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQK-LETRIRELEFELEGEQKKNTESVKG 1840
Query: 438 LKKEERRHAEAKDQLERALRAMQVAKDSLEHLASKLIHITVEDGRFAGKELDPQADNYVP 497
L+K ERR E Q E + + +D ++ L + V+ + +E D QA+ ++
Sbjct: 1841 LRKYERRVKELTYQSEEDRKNVLRLQDLVDKL-----QVKVKSYKRQAEEADEQANAHLT 1895
Query: 498 NL-------------LGLVEEKLLKLQAQLQGHDVQEMLCH 525
+ E ++ KL+A+ + M+ H
Sbjct: 1896 KFRKAQHELEEAEERADIAESQVNKLRAKTRDFTSSRMVVH 1936
Score = 57.0 bits (136), Expect = 5e-08
Identities = 87/414 (21%), Positives = 179/414 (43%), Gaps = 60/414 (14%)
Query: 70 QVAELHKKIQLLEGDRKAFFESSQW---NIKKNQETISQLRKETKALELKLLDL------ 120
+++ L + I L ++KA E+ Q +++ ++ ++ L K LE ++ DL
Sbjct: 982 ELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQ 1041
Query: 121 --------------LKGDEKVVQAVIREWKWEKPYLKNRTGQA-LEHLDHRLREKVKQQN 165
L+GD K+ Q I + + +K L R + E+ + + + +Q
Sbjct: 1042 EKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTL 1101
Query: 166 ALRHQVVLR--QRRLEELQLQHSLRLLEMAEAQNRHTEVAKTMRNLENRLEKAQMKAQEA 223
L+ Q ++ Q R+EEL+ + A+ + + ++ A+ + L RLE EA
Sbjct: 1102 GLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLE-------EA 1154
Query: 224 EHITSVYLQLKAYLMDESLNLENRLDSMEAEVVRTKHELEALHVVNQEALNARDIAKNQL 283
+TS ++L E L L L E +HE + + A + ++ +
Sbjct: 1155 GGVTSTQIELNKKREAEFLKLRRDL-----EEATLQHEAMVAALRKKHADSVAELGEQ-- 1207
Query: 284 QYLEETLVRERKKRERYISECKKRAEEKKLENERMER-KTHREHLLLQSDDTIQDSLHAK 342
+ L R ++K E+ SE K ++ E + + K + E + +D + ++ K
Sbjct: 1208 ---IDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEA-RGK 1263
Query: 343 EEELRQRWSMYQMEVIFGKVKDATGTDETHSLVRRFLAQGDTFAQLETLKSENEQTLVRL 402
EE+++ S E+ K + T E L R+ + E++ S+ ++
Sbjct: 1264 NEEIQRSLS----ELTTQKSRLQT---EAGELSRQ-------LEEKESIVSQLSRSKQAF 1309
Query: 403 KQEKQQLQRELEDLKYSGEATLVSQQKLQAEAQERLKKEERRHAEAKDQLERAL 456
Q+ ++L+R+LE+ + A + Q + + + L+++ E K +L+RAL
Sbjct: 1310 TQQTEELKRQLEEENKAKNALAHALQSSRHDC-DLLREQYEEEQEGKAELQRAL 1362
Score = 55.1 bits (131), Expect = 2e-07
Identities = 111/513 (21%), Positives = 195/513 (38%), Gaps = 70/513 (13%)
Query: 64 KPSVHSQVAELHKKIQLLEGDRKAFFESSQWNIKKNQETISQLRKETKALELKL------ 117
K + ++ EL ++++ E S Q ++ +E QL +E KA
Sbjct: 1278 KSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSS 1337
Query: 118 ---LDLLK--------GDEKVVQAV------IREW--KWEKPYLKN--RTGQALEHLDHR 156
DLL+ G ++ +A+ + +W K+E ++ +A + L R
Sbjct: 1338 RHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQR 1397
Query: 157 LREKVKQQNALRHQVVLRQRRLEELQLQHSLRLLEMAEAQNRHTEVAKTMRNLENRLEKA 216
L++ +Q A+ + ++ + LQ + ++++ A + + K RN + L +
Sbjct: 1398 LQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEW 1457
Query: 217 QMKAQEAEHITSVYLQLKAYLMDESLNLEN----RLDSMEAEVVRTKH-ELEALHVVNQE 271
+ K +E++ L+ L E L+N LD +E K+ E E + Q
Sbjct: 1458 KTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQI 1517
Query: 272 ALNARDIAKNQLQYLEETLVRERKKRERYISECKKRAEEKKLENERMERKTHREHL-LLQ 330
A N + I L + RK+ E ++ + EE + E E K R L L Q
Sbjct: 1518 AENGKTI---------HELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQ 1568
Query: 331 SDDTIQDSLHAKEEELRQRWSMYQMEV-IFGKVKDATGTDETHSLVRRFLAQGD---TFA 386
I + K+EE+ Q YQ V DA ++ + +GD
Sbjct: 1569 VKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEI 1628
Query: 387 QLETLKSENEQTLVRLKQEKQQLQ----------RELEDLKYSGEATLVSQQKLQAEAQE 436
QL + +TL L+ + QL+ R EDLK LQAE +E
Sbjct: 1629 QLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEE 1688
Query: 437 ---RLKKEERRHAEAKDQL---ERALRAMQVAKDSLEHLASKL------IHITVEDGRFA 484
L++ ER A+ +L ++ + SL H KL + VED
Sbjct: 1689 LRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRD 1748
Query: 485 GKELDPQADNYVPNLLGLVEEKLLKLQAQLQGH 517
+ + +A + + + EE LK + H
Sbjct: 1749 ARNAEEKAKKAITDAAMMAEE--LKKEQDTSAH 1779
>gi|239745127 PREDICTED: similar to Putative golgin subfamily A
member 6-like protein 6 [Homo sapiens]
Length = 655
Score = 68.9 bits (167), Expect = 1e-11
Identities = 94/451 (20%), Positives = 207/451 (45%), Gaps = 69/451 (15%)
Query: 70 QVAELHKKIQLLEGDRKAFFESSQWNIKKNQETI-SQLRKETKALELKLLDLLKGDEKVV 128
Q E K++ D +A ++ ++KKN + + S +K + + K K
Sbjct: 98 QCKESLKRVTFTLPDDEAIEDAGVSHVKKNSDEVKSSFKKRQEKMNEKNYTFRK------ 151
Query: 129 QAVIREWKWEKPYLK-----------NRTGQALEHLDHRLR-----EKV-KQQNAL---- 167
+ VI+ KP+L+ N + H DH +R EK+ K+++AL
Sbjct: 152 RVVIK-----KPWLRLGEVTAQKRPENSLLEETLHFDHAVRMGTYIEKLTKERDALSLEL 206
Query: 168 -RHQVVLRQRRLEELQLQHSLRLLEMAEAQNRHTEVAKTMRNLENRLEKAQMKAQEAE-- 224
R+ + + + + +LQ LRL+E + +E+ +++L+ +LE+AQ+ + +
Sbjct: 207 YRNTITDEELKEKNAELQEKLRLVE-----SEKSEIQLNVKDLKRKLERAQLLLPQQQLQ 261
Query: 225 --------HITSVYLQLKAYLMDESL-NLENRLDSMEAEVVRTKHEL-EALHVVNQEALN 274
+ SV +L+A + + L NL N+ E ++ R + ++ E + ++ L
Sbjct: 262 VEADRLGKELQSVSAKLQAQVEENELWNLLNQ--QQEEKMWRQEEKIQEQEEKMCEQELK 319
Query: 275 ARDIAKNQLQYLEETLVRERKKRER----YISECKKRAEEKKLENERMERKTHREHLLLQ 330
R+ + + E+ +E K RE+ + E K R +E+K+ E+ E+ +E + +
Sbjct: 320 IREQEEKMWRQEEKMHEQEEKIREQEDKMWRQEEKIREQEEKIR-EQEEKMWRQEEKIRE 378
Query: 331 SDDTIQDS---LHAKEEELRQRWSMYQMEVIFGKVKDATGTDETHSLVRRFLAQGDTFAQ 387
D+ IQ+ + +EE++R++ Q ++ + K ++ Q + +
Sbjct: 379 QDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRE 438
Query: 388 LETLKSENEQTLVRLKQEKQQLQRELEDLKYSGEATLVSQQKLQAEA-----QERLKKEE 442
LE + + E+ +L++ ++++Q E E ++ E ++K+Q + QE+L K+E
Sbjct: 439 LEEMMQDQEE---KLREVEEKMQEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLKQE 495
Query: 443 RRHAEAKDQLERALRAMQVAKDSLEHLASKL 473
+ E ++++ R M ++ ++ K+
Sbjct: 496 EKIWEQEEKMWRQEEKMWEQEEKMQEQEEKM 526
Score = 40.0 bits (92), Expect = 0.006
Identities = 77/400 (19%), Positives = 162/400 (40%), Gaps = 49/400 (12%)
Query: 74 LHKKIQLLEGDRKAFFESSQ-WNIKKNQETISQLRKETKALE---------LKLLD---- 119
L K++Q + +A E ++ WN+ Q+ R+E K E LK+ +
Sbjct: 267 LGKELQSVSAKLQAQVEENELWNLLNQQQEEKMWRQEEKIQEQEEKMCEQELKIREQEEK 326
Query: 120 -------LLKGDEKVVQAVIREWKWEKPYLKNRTG-QALEHLDHRLREKVKQQNA-LRHQ 170
+ + +EK+ + + W+ E+ + + E R EK+++Q+ ++ Q
Sbjct: 327 MWRQEEKMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQ 386
Query: 171 VVLRQRRLEELQLQHSLRLLEMAEAQNRHTEVAKTMRNLENRLEKAQMKAQEAEHITSVY 230
R+ E+++ Q R +M + + E + +R E + + + K +E E +
Sbjct: 387 EEEMWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQ 446
Query: 231 LQLKAYLMDESLNLENRLDSMEAEVVRTKHELEALHVVNQEALNARDIAKNQLQYLEETL 290
+ + ++ E ++ E ++ R + +++ QE R + +L EE +
Sbjct: 447 EEKLREVEEKMQEEEEKMQEQEEKIQRQEEKIQ-----EQEEKTWR---QEKLLKQEEKI 498
Query: 291 VRERKKRERYISECKKRAEEKKLENERMERKTHREHLLLQSDDTIQDSLHAKEEELRQRW 350
+ +K R E K +E+K++ + + + E + Q Q +E+E+R
Sbjct: 499 WEQEEKMWR--QEEKMWEQEEKMQEQEEKMQRQEEKMREQEVRLWQQEEKMQEQEVR--- 553
Query: 351 SMYQMEVIFGKVKDATGTDETHSLVRRFLAQGDTFAQLETLKSENEQTLVRLK-QEKQQL 409
+ ++E GK+ L + + L + V LK QE Q L
Sbjct: 554 -LQELEERLGKLGQKA----------ELLGGAGRESGSQRLPTLTPILQVELKSQEAQSL 602
Query: 410 QRELEDLKYSGEATLVSQQKLQAEAQERLKKEERRHAEAK 449
Q++ + + + + + Q+L A +E L R AK
Sbjct: 603 QQQQDHYRGHLQQYVAAYQQL-ASGKEALPSCSSRKLRAK 641
>gi|64085252 hypothetical protein LOC145508 [Homo sapiens]
Length = 1094
Score = 68.9 bits (167), Expect = 1e-11
Identities = 118/551 (21%), Positives = 222/551 (40%), Gaps = 88/551 (15%)
Query: 70 QVAELHKKIQLLEGDRKAFF----------------ESSQWNIKKNQETISQ-LRKETKA 112
QV EL ++ EGDRK + W ++ E Q L K+
Sbjct: 308 QVEELRTQLTKAEGDRKGLQHQVSQISKQQSNYQDEQGEDWRFRRGVEREKQDLEKQMSD 367
Query: 113 LELKL-LDLLKGDEKVVQAVIREWKWEKPYLKNRTGQALEHLDHRLREKVKQQNALRHQV 171
L ++L + + + V+ + EK +L ++ +E+L L KQQ + ++
Sbjct: 368 LRVQLNFSAMASELEEVKRCMERKDKEKAHLASQ----VENLTRELENGEKQQLQMLDRL 423
Query: 172 VLRQRRLEELQLQHSLRLLEMAEAQNRHTEVAKTMRNLENRLEKAQMKAQEAEHITSVYL 231
Q + + + L+++E + K + L++++ +EAE L
Sbjct: 424 KEIQNHFDTCEAERKHADLQISELTRHAEDATKQAERYLSELQQSEALKEEAEKRRED-L 482
Query: 232 QLKAYLMDESLNLENRLDSMEAEVVRTKHELEALHVVNQEALNARDIAKNQLQYLEETLV 291
+LKA L+++ +E + + ++ L N + L +D K QL + +
Sbjct: 483 KLKAQESIRQWKLKHK--KLERALEKQSETVDELTGKNNQILKEKDELKTQLYAALQQIE 540
Query: 292 RERKKRERYISECKKRAEEKKLENERM-ERKTHREHLLLQSDDTIQDSLHAKEEELRQRW 350
RK+ +++ + EE + E++ + K+H+ L L+ +++ D++H E EL+++
Sbjct: 541 NLRKELNDVLTKRALQEEELHSKEEKLRDIKSHQADLELEVKNSL-DTIHRLESELKKQS 599
Query: 351 SMYQ--------MEVIFGKVKDATGTDETH-----------SLVRRFLAQ---------- 381
+ +E ++K + D+ S +R LA
Sbjct: 600 KIQSQMKVEKAHLEEEIAELKKSQAQDKAKLLEMQESIKDLSAIRADLANKLAEEERAKK 659
Query: 382 ------GDTFAQLETLKSENEQTLVRLKQEKQQLQRELEDLKYSGEATLVSQQKLQAEAQ 435
D AQ ++ E + +LK E+ QREL+DL S ++ + K + Q
Sbjct: 660 AVLKDLSDLTAQAKSRDEETATIITQLKLERDVHQRELKDLTSSLQSV---KTKHEQNIQ 716
Query: 436 ERLKKEERRHAEAKDQLERALRAMQVAKDSLEHLASKLIHITVEDGRFAGKELDPQADNY 495
E +K ++ +EA++ + R L+A +SLE IH R ++L Q D
Sbjct: 717 ELMKHFKKEKSEAENHI-RTLKA-----ESLEEKNMAKIH------RGQLEKLKSQCDRL 764
Query: 496 VPNLL-GLVEEKLLKLQAQLQGHDVQEMLCHIANREFLASLEGRLPEYNTRIALPLATSK 554
L E K LKL+ Q ++E HI+ E E+ R+ K
Sbjct: 765 TEELTQNENENKKLKLKYQCLKDQLEEREKHISIEE----------EHLRRMEEARLQLK 814
Query: 555 DKFFDEESEEE 565
D+ E+E+E
Sbjct: 815 DQLLCLETEQE 825
Score = 67.0 bits (162), Expect = 5e-11
Identities = 95/477 (19%), Positives = 195/477 (40%), Gaps = 74/477 (15%)
Query: 69 SQVAELHKKIQLLEGDRKAFFESSQWNIKKNQETISQLRKETKALELKLLDLLKGD---- 124
+Q+ H+ ++ L ++ + + + + ++ ++ + L KL + K +
Sbjct: 159 TQLHGFHQSLRDLSSEQIRLGDDFNRELSRRSRSDAETKRALEELTEKLNEAQKQEVVSD 218
Query: 125 --EKVVQAVIREWKWEKPYLKNRTGQALEHLDHRLREKVKQQNAL--RHQVV----LRQR 176
E+ +Q + RE + E+ ++ R Q L + +L+E +K+Q A H+ LRQ
Sbjct: 219 RVERRLQELEREMRTERELVERRQDQ-LGLMSLQLQEALKKQEAKADEHEGAIKNKLRQT 277
Query: 177 RLEELQLQHSLRLLE--MAEAQNRHTEVAKTMRNLENRLEKAQMKAQEAEHITSVYLQLK 234
E+ QL+ L L + +++ + + L +L KA+ + +H S + +
Sbjct: 278 ETEKNQLEQELELSRRLLNQSEGSRETLLHQVEELRTQLTKAEGDRKGLQHQVSQISKQQ 337
Query: 235 AYLMDES-----------------------LNLENRLDSMEAEVVRTKH-----ELEALH 266
+ DE L ++ +M +E+ K + E H
Sbjct: 338 SNYQDEQGEDWRFRRGVEREKQDLEKQMSDLRVQLNFSAMASELEEVKRCMERKDKEKAH 397
Query: 267 VVNQEALNARDIA---KNQLQYLE---------ETLVRERKKRERYISECKKRAEEKKLE 314
+ +Q R++ K QLQ L+ +T ERK + ISE + AE+ +
Sbjct: 398 LASQVENLTRELENGEKQQLQMLDRLKEIQNHFDTCEAERKHADLQISELTRHAEDATKQ 457
Query: 315 NERMERKTHREHLLLQSDDTIQDSLHAKEEELRQRWSMYQMEVIFGKVKDATGTDETHSL 374
ER + + L + + ++ L K +E ++W + ++ K + DE
Sbjct: 458 AERYLSELQQSEALKEEAEKRREDLKLKAQESIRQWKLKHKKLERALEKQSETVDELTGK 517
Query: 375 VRRFLAQGD--------TFAQLETLKSENEQTLVRLKQEKQQL---QRELEDLKYSGEAT 423
+ L + D Q+E L+ E L + ++++L + +L D+K S +A
Sbjct: 518 NNQILKEKDELKTQLYAALQQIENLRKELNDVLTKRALQEEELHSKEEKLRDIK-SHQAD 576
Query: 424 LVSQQKLQAEAQERLKKEERRHAEAKDQLERALRAMQVAKDSLEHLASKLIHITVED 480
L + K + RL+ E ++ ++ + Q M+V K LE ++L +D
Sbjct: 577 LELEVKNSLDTIHRLESELKKQSKIQSQ-------MKVEKAHLEEEIAELKKSQAQD 626
>gi|154350226 hypothetical protein LOC79632 isoform 1 [Homo sapiens]
Length = 1140
Score = 68.9 bits (167), Expect = 1e-11
Identities = 138/629 (21%), Positives = 259/629 (41%), Gaps = 124/629 (19%)
Query: 67 VHSQVAELHKKIQLLEGDRKAFFESSQWNIKKNQ-ETISQLRKETKALELKLLDLLKGDE 125
+ S+ + +++++ LE +R AF S ++ + Q + I +L K+ + + + +
Sbjct: 403 LESEKSRVNERLSQLEEER-AFLRSKTQSLDEEQKQQILELEKKVNEAKRTQQEYYEREL 461
Query: 126 KVVQAVIREWKWEKPYLKNRTGQALEHL--DHRLREKVKQQNALRHQVVLRQRRLEELQL 183
K +Q+ + E E L + LE L H + + NA+R + L+ +L+
Sbjct: 462 KNLQSRLEE---EVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKKLQM----DLEE 514
Query: 184 QHSLRLLEMAEAQNRHTEVAKTMRNLENRLE-KAQMKAQEAEHITSVYLQ---------- 232
QH+ L + E +N ++ + + NL+ LE K QE H+ + +
Sbjct: 515 QHNKDKLNLEEDKN---QLQQELENLKEVLEDKLNTANQEIGHLQDMVRKSEQGLGSAEG 571
Query: 233 LKAYLMDESLNLENRLDSMEAEVVRTKH-------ELEALHVVNQEALNA-RDIAKNQLQ 284
L A L D L+N LD + + TK ELE ++E + A ++ K ++
Sbjct: 572 LIASLQDSQERLQNELDLTKDSLKETKDALLNVEGELEQERQQHEETIAAMKEEEKLKVD 631
Query: 285 YLEETLVRERKKRERYISECKKRAEEKKLENERMERKTHREHLLLQSD---DTIQDSLHA 341
+ L E K E EC K EE +L++E ++K+ LL D + +DS
Sbjct: 632 KMAHDL--EIKWTENLRQECSKLREELRLQHEE-DKKSAMSQLLQLKDREKNAARDSWQK 688
Query: 342 KEEEL----------------RQRWSMYQMEVIFGK-----VKDATGTDETHSLVRRFLA 380
K E+L + + S+ Q++ F + ++ +E H + L
Sbjct: 689 KVEDLLNQISLLKQNLEIQLSQSQTSLQQLQAQFTQERQRLTQELEELEEQHQQRHKSLK 748
Query: 381 QGDTFA-------------------------QLETLKSENEQTL----VRLKQEKQQLQR 411
+ A +L++LK + +++ + ++QE Q L+
Sbjct: 749 EAHVLAFQTMEEEKEKEQRALENHLQQKHSAELQSLKDAHRESMEGFRIEMEQELQTLRF 808
Query: 412 ELEDLKYSGEATLVSQQKLQAEAQERLKKEERRH--AEAKDQLERALRAMQVAKDSLEHL 469
ELED + A+L S+ Q A L + A AK +LER++ + + S EH+
Sbjct: 809 ELEDEGKAMLASLRSELNHQHAAAIDLLRHNHHQELAAAKMELERSIDISR--RQSKEHI 866
Query: 470 ASKL-IHITVEDGRFAGKELDPQADNYVPNLLGLVEE------KLLKL------QAQLQG 516
+ + ELD + + N+ L +E ++L++ Q +L
Sbjct: 867 CRITDLQEELRHREHHISELDKEVQHLHENISALTKELEFKGKEILRIRSESNQQIRLHE 926
Query: 517 HDVQEML---------CHIANREFLAS----LEGRLPEYNTRIALPLATSKDKFFDEESE 563
D+ + L H+ + + + L E N + + L ++K+ ES+
Sbjct: 927 QDLNKRLEKELDVMTADHLREKNIMRADFNKTNELLKEINAALQVSLEEMEEKYLMRESK 986
Query: 564 EEDNEVVT--RASLKIRSQ---KLIESHK 587
ED +++T +A L R Q KLIE +K
Sbjct: 987 PEDIQMITELKAMLTERDQIIKKLIEDNK 1015
Score = 65.9 bits (159), Expect = 1e-10
Identities = 104/482 (21%), Positives = 201/482 (41%), Gaps = 70/482 (14%)
Query: 51 GRSKGGSFHRGAGKPSVHSQVAELH----KKIQLLEGD---RKAFFESSQWNIKKNQETI 103
G+ K HR + S++ + EL K I+ EG ++F+E +K++Q
Sbjct: 215 GQEKAEELHRMEVE-SLNKMLEELRLERKKLIEDYEGKLNKAQSFYERELDTLKRSQLFT 273
Query: 104 SQLRKETKALELKLLDLLKGDEKVVQAVIREWKWEKPYLKNRTGQALEHLDHRLREKVKQ 163
++ + +K E L +G E +++ I + K E +++ G L+ K
Sbjct: 274 AESLQASKEKEADLRKEFQGQEAILRKTIGKLKTELQMVQDEAGSLLDKCQ-------KL 326
Query: 164 QNAL---RHQVVLRQRRLEELQLQHSLRLLEMAEAQNRHTEVAKTMRNLENRLEK-AQMK 219
Q AL + V + Q++L++ + + + LL ++H EV + RL++ A
Sbjct: 327 QTALAIAENNVQVLQKQLDDAK-EGEMALL------SKHKEVESELAAARERLQQQASDL 379
Query: 220 AQEAEHITSVYLQLKAYLMDESLNLENRLDSMEAEVVRTKHELEALHVVNQEALNARDIA 279
+A HI L+A M + + +++ +E+E R L L R
Sbjct: 380 VLKASHIG----MLQATQMTQEVTIKD----LESEKSRVNERLSQLE-------EERAFL 424
Query: 280 KNQLQYLEETLVRERKKRERYISECKKRAEEKKLENERMERKTHREHLLLQSDDTIQDSL 339
+++ Q L+E +++++ + KK E K+ + E ER+ L+ + T +
Sbjct: 425 RSKTQSLDE------EQKQQILELEKKVNEAKRTQQEYYERELKNLQSRLEEEVTQLNEA 478
Query: 340 HAKE-EELRQRWSMYQMEVIFGKVKDATGTDETHSLVRRFLAQGDTFAQLETLKSENEQT 398
H+K EEL + M V ++D + Q D Q K E+
Sbjct: 479 HSKTLEELAWKHHMAIEAVHSNAIRD------------KKKLQMDLEEQHNKDKLNLEED 526
Query: 399 LVRLKQEKQQLQRELEDLKYSGEATLVSQQKLQAEAQERLKKEERRHAEAKDQLERALRA 458
+L+QE + L+ LED + + Q + ++++ L E A +D ER
Sbjct: 527 KNQLQQELENLKEVLEDKLNTANQEIGHLQDMVRKSEQGLGSAEGLIASLQDSQERLQNE 586
Query: 459 MQVAKDSLEHLASKLIHITVEDGRFAGKELDPQADNYVPNLLGLVEEKLLKLQAQLQGHD 518
+ + KDSL+ L+++ EL+ + + + + EE+ KL+ HD
Sbjct: 587 LDLTKDSLKETKDALLNVE--------GELEQERQQHEETIAAMKEEE--KLKVDKMAHD 636
Query: 519 VQ 520
++
Sbjct: 637 LE 638
>gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta [Homo
sapiens]
Length = 1983
Score = 68.6 bits (166), Expect = 2e-11
Identities = 95/399 (23%), Positives = 161/399 (40%), Gaps = 70/399 (17%)
Query: 101 ETISQLRKETKALELKLLDLLKGDEKVVQAVIREWKWEKPYLKNRT-------GQALEHL 153
++I +L K KALE G++ +QA + E + + +T Q +
Sbjct: 1570 KSIQELEKTKKALE--------GEKSEIQAALEEAEGALELEETKTLRIQLELSQVKAEV 1621
Query: 154 DHRLREKVKQQNALRHQVVLRQRRLEELQLQHSLRLLEMAEAQNRHTEVAKTMRNLENRL 213
D +L EK ++ LR QR +E LQ EA ++ + +LE +L
Sbjct: 1622 DRKLAEKDEECANLRRN---HQRAVESLQASLDAETRARNEALRLKKKMEGDLNDLELQL 1678
Query: 214 EKAQMKAQEAEHITSVYL--------------QLKAYLMDESLNLENRLDSMEAEVVRTK 259
A +A EA+ T + +L A L +++ LE R + AE+ +
Sbjct: 1679 GHATRQATEAQAATRLMQAQLKEEQAGRDEEQRLAAELHEQAQALERRASLLAAELEELR 1738
Query: 260 HELE----ALHVVNQEALNARDIAKNQLQYLEETLVRERKKRERYISECKKRAEEKKLEN 315
LE + + QE L A + N L L+ ++KK E +++ EE E
Sbjct: 1739 AALEQGERSRRLAEQELLEATE-RLNLLHSQNTGLLNQKKKLEADLAQLSGEVEEAAQER 1797
Query: 316 ERMERKTHREHLLLQSDDTIQDSLHAKEEELRQRWSMYQMEVIFGKVKDATGTDETHSLV 375
E K + I D+ EE +++ D + L
Sbjct: 1798 REAEEKAKK---------AITDAAMMAEELKKEQ-------------------DTSAHLE 1829
Query: 376 RRFLAQGDTFAQLETLKSENEQTLVRL-KQEKQQLQRELEDLKYSGEATLVSQQKLQAEA 434
R T +L+ E EQ +R K++ Q+L+ ++ +L EA L ++QK AEA
Sbjct: 1830 RMKKTLEQTVRELQARLEEAEQAALRGGKKQVQKLEAKVREL----EAELDAEQKKHAEA 1885
Query: 435 QERLKKEERRHAEAKDQLERALRAMQVAKDSLEHLASKL 473
+ ++K ERR E Q E + + +D ++ L SK+
Sbjct: 1886 LKGVRKHERRVKELAYQAEEDRKNLARMQDLVDKLQSKV 1924
Score = 61.2 bits (147), Expect = 3e-09
Identities = 90/451 (19%), Positives = 173/451 (38%), Gaps = 91/451 (20%)
Query: 102 TISQLRKETKALELKLLDLLKGDEKVVQA--------VIREWKWEKPYLKN----RTGQA 149
T+ Q R + + L+ LL G + + ++ W W K + K R+ QA
Sbjct: 835 TLLQARSRGRLMRLEYQRLLGGRDALFTIQWNIRAFNAVKNWSWMKLFFKMKPLLRSAQA 894
Query: 150 LEHLDHRLRE-----------KVKQQNALRHQVVLRQRRLEELQLQHSLRLLEMAEAQNR 198
E L E + K+Q V + Q + +L LQ +A+A+ R
Sbjct: 895 EEELAALRAELRGLRGALAAAEAKRQELEETHVSITQEK-NDLALQLQAEQDNLADAEER 953
Query: 199 HTEVAKTMRNLENRLEKAQMKAQEAEHITSVYLQLKAYLMDESLNLENRLD--------- 249
+ K+ LE ++++ + ++ E + + + L DE L+ +D
Sbjct: 954 CHLLIKSKVQLEGKVKELSERLEDEEEVNADLAARRRKLEDECTELKKDIDDLKLTLAKA 1013
Query: 250 -------------------SMEAEVVRTKHELEALHVVNQEALNARDIAKNQLQYLEETL 290
+++ V R E +AL +Q+AL ++++ L +
Sbjct: 1014 EKEKQATENKVKNLTEEMAALDESVARLTKEKKALQEAHQQALGDLQAEEDRVSALTKAK 1073
Query: 291 VRERKKRERYISECKKRAEEK-KLENERMERKTHREHLLLQSD--------DTIQDSLHA 341
+R ++ E EC E+K +++ ER +RK + L Q +++ L
Sbjct: 1074 LRLEQQVEDL--ECSLEQEKKLRMDTERAKRKLEGDLKLTQESVADAAQDKQQLEEKLKK 1131
Query: 342 KEEELRQRWSMYQMEVIFG-----KVKDATGTDETHSLVRRFLAQGDTFAQLETLKSENE 396
K+ EL Q + E + G K+K+ E L A+ A++E ++E
Sbjct: 1132 KDSELSQLSLRVEDEQLLGAQMQKKIKELQARAE--ELEEELEAERAARARVEKQRAEAA 1189
Query: 397 QTLVRLKQEKQQ---------------------LQRELEDLKYSGEATLVSQQKLQAEAQ 435
+ L L + ++ L+RELE+ EAT+ + ++ QAE
Sbjct: 1190 RELEELSERLEEAGGASAGQREGCRKREAELGRLRRELEEAALRHEATVAALRRKQAEGA 1249
Query: 436 ERLKKEERRHAEAKDQLERALRAMQVAKDSL 466
L ++ + +LE+ +++ D L
Sbjct: 1250 AELGEQVDSLQRVRQKLEKEKSELRMEVDDL 1280
Score = 57.8 bits (138), Expect = 3e-08
Identities = 71/339 (20%), Positives = 132/339 (38%), Gaps = 33/339 (9%)
Query: 143 KNRTGQALEHLDHRLREKVKQQNALRHQVVLRQRRLEELQLQHSLRLLEMAEAQNRHTEV 202
K Q+LE L +L E+ K ++AL H V + + L+ QH AE Q ++
Sbjct: 1354 KALAAQSLEELRRQLEEESKAKSALAHAVQALRHDCDLLREQHEEEAEAQAELQRLLSKA 1413
Query: 203 AKTMRNLENRLEKAQMKAQEAEHITSVYLQLKAYLMDESLNLEN-RLDSMEAEVVRTKHE 261
+ ++ E ++ E L L+ +E + N + S+E +R + E
Sbjct: 1414 NAEVAQWRSKYEADAIQRTEELEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTE 1473
Query: 262 LEALHVVNQEALNARDIAKNQLQYLEETLVRERKKRERYISECKKRAEEKKLENERMERK 321
E + + + A +A + ++LE L R++ E E + E + + R
Sbjct: 1474 SEDVTLELERATSAAAALDKKQRHLERALEERRRQEEEMQRELEAAQRESRGLGTELFRL 1533
Query: 322 THREHLLLQSDDTIQDSLHAKEEELRQRWSMYQMEVIFGKVKDATGTDETHSLVRRFLAQ 381
H L++ +T++ +EE+ L +
Sbjct: 1534 RHGHEEALEALETLKRENKNLQEEI-------------------------SDLTDQVSLS 1568
Query: 382 GDTFAQLETLKS--ENEQTLVRLKQEKQQLQRELEDLKYSGEATLVSQQKLQAEAQERLK 439
G + +LE K E E++ ++ E+ + ELE+ K +SQ K + + + K
Sbjct: 1569 GKSIQELEKTKKALEGEKSEIQAALEEAEGALELEETKTLRIQLELSQVKAEVDRKLAEK 1628
Query: 440 KEE-----RRHAEAKDQLERALRAMQVAKDSLEHLASKL 473
EE R H A + L+ +L A A++ L K+
Sbjct: 1629 DEECANLRRNHQRAVESLQASLDAETRARNEALRLKKKM 1667
Score = 48.9 bits (115), Expect = 1e-05
Identities = 102/452 (22%), Positives = 178/452 (39%), Gaps = 69/452 (15%)
Query: 68 HSQVAELHKKIQLLEGDRKAFFESSQWNIKKNQETISQLRKETKALELKLLDLLKGDEKV 127
H + AE ++Q L KA E +QW K + I + + +A + L L + +E V
Sbjct: 1396 HEEEAEAQAELQRLLS--KANAEVAQWRSKYEADAIQRTEELEEAKKKLALRLQEAEEGV 1453
Query: 128 VQAVIREWKWEKPYLKNRTGQA-----LEHLDHRLREKVKQQNALRHQVVLRQRRLEELQ 182
A + EK L+ +T LE K+Q L + R+R+ EE+Q
Sbjct: 1454 EAANAKCSSLEKAKLRLQTESEDVTLELERATSAAAALDKKQRHLERALEERRRQEEEMQ 1513
Query: 183 LQHSLRLLEMAEAQNRH--TEVAKTMRNLENRLEKAQMKAQEAEHITSVYLQLKAYLMDE 240
R LE A+ ++R TE+ + E LE + +E ++ L +E
Sbjct: 1514 -----RELEAAQRESRGLGTELFRLRHGHEEALEALETLKRENKN-----------LQEE 1557
Query: 241 SLNLENRLDSMEAEVVRTKHELEALHVVNQEALNARDIAKNQLQYLEETLVRERKKRERY 300
+L +++ + + +AL E A + A+ L+ E +R + + +
Sbjct: 1558 ISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEGALELEETKTLRIQLELSQV 1617
Query: 301 ISECKKRAEEKKLENERMERKTHREHLLLQSDDTIQDSLHAKEEELRQRWSMYQMEVIFG 360
+E ++ EK E + R R LQ+ ++ A+ E LR + M G
Sbjct: 1618 KAEVDRKLAEKDEECANLRRNHQRAVESLQA--SLDAETRARNEALRLKKKME------G 1669
Query: 361 KVKDATGTDETHSLVRRFLAQGDTFAQLETLKSENEQTLVRLKQEKQQLQRELEDLKYSG 420
+ D L G T ++ Q RL Q QL+ E
Sbjct: 1670 DLNDLE------------LQLGHA-----TRQATEAQAATRLMQA--QLKEE-------- 1702
Query: 421 EATLVSQQKLQAEAQERLKKEERRHA-------EAKDQLERALRAMQVAKDSLEHLASKL 473
+A +Q+L AE E+ + ERR + E + LE+ R+ ++A+ L +L
Sbjct: 1703 QAGRDEEQRLAAELHEQAQALERRASLLAAELEELRAALEQGERSRRLAEQELLEATERL 1762
Query: 474 IHITVEDGRFAGKELDPQADNYVPNLLGLVEE 505
+ ++ ++ +AD + L G VEE
Sbjct: 1763 NLLHSQNTGLLNQKKKLEAD--LAQLSGEVEE 1792
Score = 38.5 bits (88), Expect = 0.018
Identities = 32/125 (25%), Positives = 61/125 (48%), Gaps = 4/125 (3%)
Query: 96 IKKNQETISQLRKETKALELKLLDLLKGDEKVVQAVIREWKWEKPYLKNRTGQALEHLDH 155
+KK Q+T + L + K LE + +L E+ QA +R K + L+ + + LD
Sbjct: 1818 LKKEQDTSAHLERMKKTLEQTVRELQARLEEAEQAALRGGKKQVQKLEAKVRELEAELD- 1876
Query: 156 RLREKVKQQNALRHQVVLRQRRLEELQLQHSLRLLEMAEAQNRHTEVAKTMRNLENRLEK 215
E+ K AL+ V +RR++EL Q +A Q+ ++ +++ + + E+
Sbjct: 1877 --AEQKKHAEALK-GVRKHERRVKELAYQAEEDRKNLARMQDLVDKLQSKVKSYKRQFEE 1933
Query: 216 AQMKA 220
A+ +A
Sbjct: 1934 AEQQA 1938
Score = 33.5 bits (75), Expect = 0.57
Identities = 62/312 (19%), Positives = 119/312 (38%), Gaps = 43/312 (13%)
Query: 62 AGKPSVHSQVAELHKKIQLLEGDRKAFFESSQWNIKKNQETISQLRKETKALELKLLDLL 121
AG+ AELH++ Q LE R+A +++ +E + L + ++ L +LL
Sbjct: 1704 AGRDEEQRLAAELHEQAQALE--RRASLLAAEL-----EELRAALEQGERSRRLAEQELL 1756
Query: 122 KGDEKVV------QAVIREWKWEKPYLKNRTGQALEHLDHRLREKVKQQNALRHQVVLRQ 175
+ E++ ++ + K + L +G+ E R + K + A+ ++
Sbjct: 1757 EATERLNLLHSQNTGLLNQKKKLEADLAQLSGEVEEAAQERREAEEKAKKAITDAAMMA- 1815
Query: 176 RRLEELQLQHSLRLLEMAEAQNRHTEVAKTMRNLENRLEKAQMKAQEAEHITSVYLQLKA 235
EEL+ + A + + +T+R L+ RLE+A+ A
Sbjct: 1816 ---EELKKEQDTS----AHLERMKKTLEQTVRELQARLEEAEQAALRGG----------- 1857
Query: 236 YLMDESLNLENRLDSMEAEVVRTKHELEALHVVNQEALNARDIAKNQLQYLEETLVRERK 295
+ ++ +EA+V + EL+A + EAL + +++ L +RK
Sbjct: 1858 ---------KKQVQKLEAKVRELEAELDAEQKKHAEALKGVRKHERRVKELAYQAEEDRK 1908
Query: 296 KRERYISECKKRAEEKKLENERMERKTHREHLLLQSDDTIQDSLHAKEEELRQRWSMYQM 355
R K + K + E + + L Q L EE R + Q
Sbjct: 1909 NLARMQDLVDKLQSKVKSYKRQFEEAEQQANTNLAKYRKAQHELDDAEE--RADMAETQA 1966
Query: 356 EVIFGKVKDATG 367
+ + +DA G
Sbjct: 1967 NKLRARTRDALG 1978
>gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]
Length = 2003
Score = 68.2 bits (165), Expect = 2e-11
Identities = 100/448 (22%), Positives = 188/448 (41%), Gaps = 50/448 (11%)
Query: 70 QVAELHKKIQLLEGDRKAFFESSQWNIK---KNQETISQLRKETKALELKL--LDLLKGD 124
+V EL ++ LE +R E + + + +ET +L + LEL + L+ G+
Sbjct: 899 EVGELQGRVAQLEEERARLAEQLRAEAELCAEAEETRGRLAARKQELELVVSELEARVGE 958
Query: 125 EKVVQAVIREWKWEKPYLKNRTGQALEHLDHR--LREKVK-------------------- 162
E+ R+ + EK L+ + HL+ R+K++
Sbjct: 959 EEECS---RQMQTEKKRLQQHIQELEAHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLL 1015
Query: 163 --QQNALRHQVVLRQRRLEELQLQHSLRLLEMAEAQNRHTEVAKTMRNLENRLEKAQMKA 220
Q + L + L + RL E Q + ++ + T+ ++E+RL K +
Sbjct: 1016 EDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGR 1075
Query: 221 QEAEHITSVYLQLKAYLMDESLNLENRLDSMEAEVVRTKHELEALHVVNQEALNARDIAK 280
QE E + + L ++ + + R + + A++ R + EL+A ++ AR
Sbjct: 1076 QELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLL 1135
Query: 281 NQLQYLEETLVRERKKRERYISECKKRAEEKKLENERMERKTHREHLLLQSDDTIQDSLH 340
L+ + L ++ E +R K E +R + E L + +DT+ DS +
Sbjct: 1136 KSLREAQAALAEAQEDLE------SERVARTKAEKQRRDLGEELEALRGELEDTL-DSTN 1188
Query: 341 AKEEELRQRWSMYQMEVIFGKVKDATGTDET---HSLVRRFLAQGDTFAQLETL---KSE 394
A ++ELR + E + +++ T E R A G+ QLE K
Sbjct: 1189 A-QQELRSKREQEVTE-LKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGA 1246
Query: 395 NEQTLVRLKQEKQQLQRELEDLKYSGEATLVSQQKLQAEAQE---RLKKEERRHAEAKDQ 451
E+T + L+ E +L+ EL L+ + + +++L+ + QE R ER AEA ++
Sbjct: 1247 WEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEK 1306
Query: 452 LERALRAMQVAKDSLEHLASKLIHITVE 479
L+RA ++ +L SK I ++ E
Sbjct: 1307 LQRAQAELENVSGALNEAESKTIRLSKE 1334
Score = 59.3 bits (142), Expect = 1e-08
Identities = 86/430 (20%), Positives = 176/430 (40%), Gaps = 60/430 (13%)
Query: 64 KPSVHSQVAELHKKIQLLEGDRKAFFESSQWNIKKNQETISQLRKETKALELKLLDLLKG 123
+ Q +L ++++ L G+ + +S+ N + + ++E + ELK L+
Sbjct: 1159 RTKAEKQRRDLGEELEALRGELEDTLDST------NAQQELRSKREQEVTELK--KTLEE 1210
Query: 124 DEKVVQAVIREWKWEKPYLKNRTGQALEHLDHRLREKVKQQNALRHQVVLRQRRLEELQL 183
+ ++ +A ++E L+ R GQAL L +L + + + A + + + EL+
Sbjct: 1211 ETRIHEAAVQE-------LRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRA 1263
Query: 184 QHSLRLLEMAEAQNRHTEVAKTMRNLENRLEKAQMKAQEAEHITSVYLQLKAYLMDESLN 243
E++ Q E + R LE +L++ Q +A + E + + E N
Sbjct: 1264 -------ELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELEN 1316
Query: 244 LENRLDSMEAEVVRTKHELEALHVVNQEALNARDIAKNQLQYLEETLVRERKKRERYISE 303
+ L+ E++ +R EL + QL +E L E + + S
Sbjct: 1317 VSGALNEAESKTIRLSKELSSTEA--------------QLHDAQELLQEETRAKLALGSR 1362
Query: 304 CKKRAEEKKLENERMERKTHREHLLLQSDDTIQDSLHAKEEELRQRWSMYQMEVIFGKVK 363
+ E E++E + + T Q L W Q E
Sbjct: 1363 VRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQL--------SEWRRRQEE------- 1407
Query: 364 DATGTDETHSLVRRFLAQGDTFAQLETLKSENEQTLVRLKQEKQQLQRELEDLKYSGEAT 423
+A + RR + + Q K+E T+ RL++ +++LQ+EL+D
Sbjct: 1408 EAGALEAGEEARRRAAREAEALTQRLAEKTE---TVDRLERGRRRLQQELDD----ATMD 1460
Query: 424 LVSQQKLQAEAQERLKKEERRHAEAKDQLERALRAMQVAKDSLEHLASKLIHIT--VEDG 481
L Q++L + +++ +K ++ AE K + RA+ + A+ ++ + +T +E+
Sbjct: 1461 LEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEE 1520
Query: 482 RFAGKELDPQ 491
+ A +EL+ Q
Sbjct: 1521 QEAREELERQ 1530
Score = 52.8 bits (125), Expect = 9e-07
Identities = 113/524 (21%), Positives = 206/524 (39%), Gaps = 102/524 (19%)
Query: 90 ESSQWNIKKNQETISQLRKETKALELKLLDLLKGDEKVVQAVIREWKWEKPY---LKNRT 146
E+ + + ET+ +L + + L+ +L D E+ Q V K ++ + L
Sbjct: 1427 EALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEK 1486
Query: 147 GQALEHLDHRLR------EKVKQQNALRHQVVLRQRRLEELQLQHSLRLLEMAEAQNRHT 200
L ++ R R E+ + +L + Q EEL+ Q+ E+ +
Sbjct: 1487 AAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKD 1546
Query: 201 EVAKTMRNLENRLEKAQMKAQEAEHITSVYLQLKAYLMDESLNLENRLDSMEAEVVRTKH 260
+V K++ LE A+ A + L + LE+ L + E +R +
Sbjct: 1547 DVGKSVHELERACRVAEQAAND--------------LRAQVTELEDELTAAEDAKLRLEV 1592
Query: 261 ELEALHVVNQEALNARDIA----KNQL--QYLEETLVRERKKRERYISECKKRAEEKKLE 314
++AL ++ L RD A + QL Q + + R+ ++++R ++ A KKLE
Sbjct: 1593 TVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAV----AARKKLE 1648
Query: 315 NERMERKTHREHLLLQSDDTIQDSLHAKEEELRQ-RWSMYQMEVIFGKVKDATGTDETHS 373
E E K + + KEE ++Q R QM+ ++ +V+
Sbjct: 1649 GELEELKAQ-----------MASAGQGKEEAVKQLRKMQAQMKELWREVE---------- 1687
Query: 374 LVRRFLAQGDTFAQLETLKSENEQTLVRLKQEKQQLQRELEDLKYSGEATLVSQQKLQAE 433
+T E + S+N ++ RLK + ++ R E+L S A +QQ
Sbjct: 1688 ---------ETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEM 1738
Query: 434 AQE----RLKK----EERRHAEAK-DQLERALRAMQVAKDSLEHLASKLI----HITVED 480
A E L K EE+R E + QLE L Q + L KL+ +T E
Sbjct: 1739 ADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTE- 1797
Query: 481 GRFAGKELDPQADNYVPNLLGLVEEKLLKLQAQLQGHDVQEMLCHIANREFLASLEGRLP 540
A + +A++ L E ++ +L+ +L D H + +A+LE +L
Sbjct: 1798 -LSAERSFSAKAESGRQQL----ERQIQELRGRLGEEDAGARARH---KMTIAALESKLA 1849
Query: 541 EYNTRIALPLATSKDKFFDEESEEEDNEVVTRASLKIRSQKLIE 584
+ +E+ E+E E + L R++K ++
Sbjct: 1850 Q----------------AEEQLEQETRERILSGKLVRRAEKRLK 1877
Score = 52.0 bits (123), Expect = 2e-06
Identities = 78/395 (19%), Positives = 164/395 (41%), Gaps = 52/395 (13%)
Query: 103 ISQLRKETKALELKLLDLLKGDEKVVQAVIREWKWEKPYLKNRTGQALEHLDHRLREKVK 162
+++L E A E L L E VQA+ + + + + L +LR+
Sbjct: 1573 VTELEDELTAAEDAKLRL----EVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEV 1628
Query: 163 QQNALRHQVVLRQRRLEELQLQHSLRLLEMAEAQNRHTEVAKTMRNLENRLEKAQMKAQE 222
+++ R Q L ++L+ + +MA A E K +R ++ ++++ + +E
Sbjct: 1629 ERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEE 1688
Query: 223 AEHITSVYLQLKAYLMDESLNLENRLDSMEAEVVRTKHELEALHVVNQEALNARDIAKNQ 282
TS + + ++ E RL +EAEV+R + EL A ++A RD ++
Sbjct: 1689 TR--TS-----REEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADE 1741
Query: 283 L---QYLEETLVRERKKRERYISECKKRAEEKKLENERMERKTHREHLLLQSDDT---IQ 336
+ + ++ E+++ E + + ++ EE++ +E + + + L ++S T +
Sbjct: 1742 VANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAE 1801
Query: 337 DSLHAKEEELRQRWSMYQMEVIFGKV-KDATGTDETHSL----VRRFLAQGDTFAQLETL 391
S AK E RQ+ Q++ + G++ ++ G H + + LAQ + + ET
Sbjct: 1802 RSFSAKAESGRQQLER-QIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQETR 1860
Query: 392 KSENEQTLVRLKQEK-----------------------------QQLQRELEDLKYSGEA 422
+ LVR +++ +QL+R+LE+ +
Sbjct: 1861 ERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASR 1920
Query: 423 TLVSQQKLQAEAQERLKKEERRHAEAKDQLERALR 457
+++LQ E ++ + E + E R R
Sbjct: 1921 AQAGRRRLQRELEDVTESAESMNREVTTLRNRLRR 1955
Score = 50.4 bits (119), Expect = 4e-06
Identities = 85/382 (22%), Positives = 159/382 (41%), Gaps = 35/382 (9%)
Query: 67 VHSQVAELHKKIQLLEGDRKAFFESSQWNIKKNQETISQLRKETKALELKLLDLLKGDEK 126
+ +QV EL ++ E D K E + +K E Q R E + L D +
Sbjct: 1569 LRAQVTELEDELTAAE-DAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAE 1627
Query: 127 VVQAVIREWKWEKPYLKNRTGQALEHLDHRL-------REKVKQQNALRHQVVLRQRRLE 179
V + R+ + + + LE L ++ E VKQ ++ Q+ R +E
Sbjct: 1628 VERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVE 1687
Query: 180 ELQLQHSLRLLEMAEAQNRHTEVAKTMRNLENRL---EKAQMKAQE-----AEHITSVYL 231
E + + E++ R + + L+ L ++A+ +AQ+ A+ + + L
Sbjct: 1688 ETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNL 1747
Query: 232 QLKAYLMDESLNLENRLDSMEAEVVRTKHELEALH------VVNQEALNARDIAKNQLQY 285
KA +++E LE RL +E E+ + E L+ ++ E+L A+
Sbjct: 1748 S-KAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSA 1806
Query: 286 LEETLVRERKKRERYISECKKRAEEKKLENERMERKTHR--EHLLLQSDDTIQDSLHAK- 342
E+ R++ ER I E + R E+ + T E L Q+++ ++ +
Sbjct: 1807 KAES---GRQQLERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERI 1863
Query: 343 -EEELRQRWSMYQMEVIFGKVKDATGTDETHSLVRRFLAQGDT-FAQLETLKSENEQTLV 400
+L +R EV+ ++ D+ +R L +G+ QL+ E E+
Sbjct: 1864 LSGKLVRRAEKRLKEVVLQVEEERRVADQ----LRDQLEKGNLRVKQLKRQLEEAEEEAS 1919
Query: 401 RLKQEKQQLQRELEDLKYSGEA 422
R + +++LQRELED+ S E+
Sbjct: 1920 RAQAGRRRLQRELEDVTESAES 1941
>gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]
Length = 1995
Score = 68.2 bits (165), Expect = 2e-11
Identities = 100/448 (22%), Positives = 188/448 (41%), Gaps = 50/448 (11%)
Query: 70 QVAELHKKIQLLEGDRKAFFESSQWNIK---KNQETISQLRKETKALELKL--LDLLKGD 124
+V EL ++ LE +R E + + + +ET +L + LEL + L+ G+
Sbjct: 891 EVGELQGRVAQLEEERARLAEQLRAEAELCAEAEETRGRLAARKQELELVVSELEARVGE 950
Query: 125 EKVVQAVIREWKWEKPYLKNRTGQALEHLDHR--LREKVK-------------------- 162
E+ R+ + EK L+ + HL+ R+K++
Sbjct: 951 EEECS---RQMQTEKKRLQQHIQELEAHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLL 1007
Query: 163 --QQNALRHQVVLRQRRLEELQLQHSLRLLEMAEAQNRHTEVAKTMRNLENRLEKAQMKA 220
Q + L + L + RL E Q + ++ + T+ ++E+RL K +
Sbjct: 1008 EDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGR 1067
Query: 221 QEAEHITSVYLQLKAYLMDESLNLENRLDSMEAEVVRTKHELEALHVVNQEALNARDIAK 280
QE E + + L ++ + + R + + A++ R + EL+A ++ AR
Sbjct: 1068 QELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLL 1127
Query: 281 NQLQYLEETLVRERKKRERYISECKKRAEEKKLENERMERKTHREHLLLQSDDTIQDSLH 340
L+ + L ++ E +R K E +R + E L + +DT+ DS +
Sbjct: 1128 KSLREAQAALAEAQEDLE------SERVARTKAEKQRRDLGEELEALRGELEDTL-DSTN 1180
Query: 341 AKEEELRQRWSMYQMEVIFGKVKDATGTDET---HSLVRRFLAQGDTFAQLETL---KSE 394
A ++ELR + E + +++ T E R A G+ QLE K
Sbjct: 1181 A-QQELRSKREQEVTE-LKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGA 1238
Query: 395 NEQTLVRLKQEKQQLQRELEDLKYSGEATLVSQQKLQAEAQE---RLKKEERRHAEAKDQ 451
E+T + L+ E +L+ EL L+ + + +++L+ + QE R ER AEA ++
Sbjct: 1239 WEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEK 1298
Query: 452 LERALRAMQVAKDSLEHLASKLIHITVE 479
L+RA ++ +L SK I ++ E
Sbjct: 1299 LQRAQAELENVSGALNEAESKTIRLSKE 1326
Score = 59.3 bits (142), Expect = 1e-08
Identities = 86/430 (20%), Positives = 176/430 (40%), Gaps = 60/430 (13%)
Query: 64 KPSVHSQVAELHKKIQLLEGDRKAFFESSQWNIKKNQETISQLRKETKALELKLLDLLKG 123
+ Q +L ++++ L G+ + +S+ N + + ++E + ELK L+
Sbjct: 1151 RTKAEKQRRDLGEELEALRGELEDTLDST------NAQQELRSKREQEVTELK--KTLEE 1202
Query: 124 DEKVVQAVIREWKWEKPYLKNRTGQALEHLDHRLREKVKQQNALRHQVVLRQRRLEELQL 183
+ ++ +A ++E L+ R GQAL L +L + + + A + + + EL+
Sbjct: 1203 ETRIHEAAVQE-------LRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRA 1255
Query: 184 QHSLRLLEMAEAQNRHTEVAKTMRNLENRLEKAQMKAQEAEHITSVYLQLKAYLMDESLN 243
E++ Q E + R LE +L++ Q +A + E + + E N
Sbjct: 1256 -------ELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELEN 1308
Query: 244 LENRLDSMEAEVVRTKHELEALHVVNQEALNARDIAKNQLQYLEETLVRERKKRERYISE 303
+ L+ E++ +R EL + QL +E L E + + S
Sbjct: 1309 VSGALNEAESKTIRLSKELSSTEA--------------QLHDAQELLQEETRAKLALGSR 1354
Query: 304 CKKRAEEKKLENERMERKTHREHLLLQSDDTIQDSLHAKEEELRQRWSMYQMEVIFGKVK 363
+ E E++E + + T Q L W Q E
Sbjct: 1355 VRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQL--------SEWRRRQEE------- 1399
Query: 364 DATGTDETHSLVRRFLAQGDTFAQLETLKSENEQTLVRLKQEKQQLQRELEDLKYSGEAT 423
+A + RR + + Q K+E T+ RL++ +++LQ+EL+D
Sbjct: 1400 EAGALEAGEEARRRAAREAEALTQRLAEKTE---TVDRLERGRRRLQQELDD----ATMD 1452
Query: 424 LVSQQKLQAEAQERLKKEERRHAEAKDQLERALRAMQVAKDSLEHLASKLIHIT--VEDG 481
L Q++L + +++ +K ++ AE K + RA+ + A+ ++ + +T +E+
Sbjct: 1453 LEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEE 1512
Query: 482 RFAGKELDPQ 491
+ A +EL+ Q
Sbjct: 1513 QEAREELERQ 1522
Score = 52.8 bits (125), Expect = 9e-07
Identities = 113/524 (21%), Positives = 206/524 (39%), Gaps = 102/524 (19%)
Query: 90 ESSQWNIKKNQETISQLRKETKALELKLLDLLKGDEKVVQAVIREWKWEKPY---LKNRT 146
E+ + + ET+ +L + + L+ +L D E+ Q V K ++ + L
Sbjct: 1419 EALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEK 1478
Query: 147 GQALEHLDHRLR------EKVKQQNALRHQVVLRQRRLEELQLQHSLRLLEMAEAQNRHT 200
L ++ R R E+ + +L + Q EEL+ Q+ E+ +
Sbjct: 1479 AAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKD 1538
Query: 201 EVAKTMRNLENRLEKAQMKAQEAEHITSVYLQLKAYLMDESLNLENRLDSMEAEVVRTKH 260
+V K++ LE A+ A + L + LE+ L + E +R +
Sbjct: 1539 DVGKSVHELERACRVAEQAAND--------------LRAQVTELEDELTAAEDAKLRLEV 1584
Query: 261 ELEALHVVNQEALNARDIA----KNQL--QYLEETLVRERKKRERYISECKKRAEEKKLE 314
++AL ++ L RD A + QL Q + + R+ ++++R ++ A KKLE
Sbjct: 1585 TVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAV----AARKKLE 1640
Query: 315 NERMERKTHREHLLLQSDDTIQDSLHAKEEELRQ-RWSMYQMEVIFGKVKDATGTDETHS 373
E E K + + KEE ++Q R QM+ ++ +V+
Sbjct: 1641 GELEELKAQ-----------MASAGQGKEEAVKQLRKMQAQMKELWREVE---------- 1679
Query: 374 LVRRFLAQGDTFAQLETLKSENEQTLVRLKQEKQQLQRELEDLKYSGEATLVSQQKLQAE 433
+T E + S+N ++ RLK + ++ R E+L S A +QQ
Sbjct: 1680 ---------ETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEM 1730
Query: 434 AQE----RLKK----EERRHAEAK-DQLERALRAMQVAKDSLEHLASKLI----HITVED 480
A E L K EE+R E + QLE L Q + L KL+ +T E
Sbjct: 1731 ADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTE- 1789
Query: 481 GRFAGKELDPQADNYVPNLLGLVEEKLLKLQAQLQGHDVQEMLCHIANREFLASLEGRLP 540
A + +A++ L E ++ +L+ +L D H + +A+LE +L
Sbjct: 1790 -LSAERSFSAKAESGRQQL----ERQIQELRGRLGEEDAGARARH---KMTIAALESKLA 1841
Query: 541 EYNTRIALPLATSKDKFFDEESEEEDNEVVTRASLKIRSQKLIE 584
+ +E+ E+E E + L R++K ++
Sbjct: 1842 Q----------------AEEQLEQETRERILSGKLVRRAEKRLK 1869
Score = 52.0 bits (123), Expect = 2e-06
Identities = 78/395 (19%), Positives = 164/395 (41%), Gaps = 52/395 (13%)
Query: 103 ISQLRKETKALELKLLDLLKGDEKVVQAVIREWKWEKPYLKNRTGQALEHLDHRLREKVK 162
+++L E A E L L E VQA+ + + + + L +LR+
Sbjct: 1565 VTELEDELTAAEDAKLRL----EVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEV 1620
Query: 163 QQNALRHQVVLRQRRLEELQLQHSLRLLEMAEAQNRHTEVAKTMRNLENRLEKAQMKAQE 222
+++ R Q L ++L+ + +MA A E K +R ++ ++++ + +E
Sbjct: 1621 ERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEE 1680
Query: 223 AEHITSVYLQLKAYLMDESLNLENRLDSMEAEVVRTKHELEALHVVNQEALNARDIAKNQ 282
TS + + ++ E RL +EAEV+R + EL A ++A RD ++
Sbjct: 1681 TR--TS-----REEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADE 1733
Query: 283 L---QYLEETLVRERKKRERYISECKKRAEEKKLENERMERKTHREHLLLQSDDT---IQ 336
+ + ++ E+++ E + + ++ EE++ +E + + + L ++S T +
Sbjct: 1734 VANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAE 1793
Query: 337 DSLHAKEEELRQRWSMYQMEVIFGKV-KDATGTDETHSL----VRRFLAQGDTFAQLETL 391
S AK E RQ+ Q++ + G++ ++ G H + + LAQ + + ET
Sbjct: 1794 RSFSAKAESGRQQLER-QIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQETR 1852
Query: 392 KSENEQTLVRLKQEK-----------------------------QQLQRELEDLKYSGEA 422
+ LVR +++ +QL+R+LE+ +
Sbjct: 1853 ERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASR 1912
Query: 423 TLVSQQKLQAEAQERLKKEERRHAEAKDQLERALR 457
+++LQ E ++ + E + E R R
Sbjct: 1913 AQAGRRRLQRELEDVTESAESMNREVTTLRNRLRR 1947
Score = 50.4 bits (119), Expect = 4e-06
Identities = 85/382 (22%), Positives = 159/382 (41%), Gaps = 35/382 (9%)
Query: 67 VHSQVAELHKKIQLLEGDRKAFFESSQWNIKKNQETISQLRKETKALELKLLDLLKGDEK 126
+ +QV EL ++ E D K E + +K E Q R E + L D +
Sbjct: 1561 LRAQVTELEDELTAAE-DAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAE 1619
Query: 127 VVQAVIREWKWEKPYLKNRTGQALEHLDHRL-------REKVKQQNALRHQVVLRQRRLE 179
V + R+ + + + LE L ++ E VKQ ++ Q+ R +E
Sbjct: 1620 VERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVE 1679
Query: 180 ELQLQHSLRLLEMAEAQNRHTEVAKTMRNLENRL---EKAQMKAQE-----AEHITSVYL 231
E + + E++ R + + L+ L ++A+ +AQ+ A+ + + L
Sbjct: 1680 ETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNL 1739
Query: 232 QLKAYLMDESLNLENRLDSMEAEVVRTKHELEALH------VVNQEALNARDIAKNQLQY 285
KA +++E LE RL +E E+ + E L+ ++ E+L A+
Sbjct: 1740 S-KAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSA 1798
Query: 286 LEETLVRERKKRERYISECKKRAEEKKLENERMERKTHR--EHLLLQSDDTIQDSLHAK- 342
E+ R++ ER I E + R E+ + T E L Q+++ ++ +
Sbjct: 1799 KAES---GRQQLERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERI 1855
Query: 343 -EEELRQRWSMYQMEVIFGKVKDATGTDETHSLVRRFLAQGDT-FAQLETLKSENEQTLV 400
+L +R EV+ ++ D+ +R L +G+ QL+ E E+
Sbjct: 1856 LSGKLVRRAEKRLKEVVLQVEEERRVADQ----LRDQLEKGNLRVKQLKRQLEEAEEEAS 1911
Query: 401 RLKQEKQQLQRELEDLKYSGEA 422
R + +++LQRELED+ S E+
Sbjct: 1912 RAQAGRRRLQRELEDVTESAES 1933
>gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]
Length = 2036
Score = 68.2 bits (165), Expect = 2e-11
Identities = 100/448 (22%), Positives = 188/448 (41%), Gaps = 50/448 (11%)
Query: 70 QVAELHKKIQLLEGDRKAFFESSQWNIK---KNQETISQLRKETKALELKL--LDLLKGD 124
+V EL ++ LE +R E + + + +ET +L + LEL + L+ G+
Sbjct: 932 EVGELQGRVAQLEEERARLAEQLRAEAELCAEAEETRGRLAARKQELELVVSELEARVGE 991
Query: 125 EKVVQAVIREWKWEKPYLKNRTGQALEHLDHR--LREKVK-------------------- 162
E+ R+ + EK L+ + HL+ R+K++
Sbjct: 992 EEECS---RQMQTEKKRLQQHIQELEAHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLL 1048
Query: 163 --QQNALRHQVVLRQRRLEELQLQHSLRLLEMAEAQNRHTEVAKTMRNLENRLEKAQMKA 220
Q + L + L + RL E Q + ++ + T+ ++E+RL K +
Sbjct: 1049 EDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGR 1108
Query: 221 QEAEHITSVYLQLKAYLMDESLNLENRLDSMEAEVVRTKHELEALHVVNQEALNARDIAK 280
QE E + + L ++ + + R + + A++ R + EL+A ++ AR
Sbjct: 1109 QELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLL 1168
Query: 281 NQLQYLEETLVRERKKRERYISECKKRAEEKKLENERMERKTHREHLLLQSDDTIQDSLH 340
L+ + L ++ E +R K E +R + E L + +DT+ DS +
Sbjct: 1169 KSLREAQAALAEAQEDLE------SERVARTKAEKQRRDLGEELEALRGELEDTL-DSTN 1221
Query: 341 AKEEELRQRWSMYQMEVIFGKVKDATGTDET---HSLVRRFLAQGDTFAQLETL---KSE 394
A ++ELR + E + +++ T E R A G+ QLE K
Sbjct: 1222 A-QQELRSKREQEVTE-LKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGA 1279
Query: 395 NEQTLVRLKQEKQQLQRELEDLKYSGEATLVSQQKLQAEAQE---RLKKEERRHAEAKDQ 451
E+T + L+ E +L+ EL L+ + + +++L+ + QE R ER AEA ++
Sbjct: 1280 WEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEK 1339
Query: 452 LERALRAMQVAKDSLEHLASKLIHITVE 479
L+RA ++ +L SK I ++ E
Sbjct: 1340 LQRAQAELENVSGALNEAESKTIRLSKE 1367
Score = 59.3 bits (142), Expect = 1e-08
Identities = 86/430 (20%), Positives = 176/430 (40%), Gaps = 60/430 (13%)
Query: 64 KPSVHSQVAELHKKIQLLEGDRKAFFESSQWNIKKNQETISQLRKETKALELKLLDLLKG 123
+ Q +L ++++ L G+ + +S+ N + + ++E + ELK L+
Sbjct: 1192 RTKAEKQRRDLGEELEALRGELEDTLDST------NAQQELRSKREQEVTELK--KTLEE 1243
Query: 124 DEKVVQAVIREWKWEKPYLKNRTGQALEHLDHRLREKVKQQNALRHQVVLRQRRLEELQL 183
+ ++ +A ++E L+ R GQAL L +L + + + A + + + EL+
Sbjct: 1244 ETRIHEAAVQE-------LRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRA 1296
Query: 184 QHSLRLLEMAEAQNRHTEVAKTMRNLENRLEKAQMKAQEAEHITSVYLQLKAYLMDESLN 243
E++ Q E + R LE +L++ Q +A + E + + E N
Sbjct: 1297 -------ELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELEN 1349
Query: 244 LENRLDSMEAEVVRTKHELEALHVVNQEALNARDIAKNQLQYLEETLVRERKKRERYISE 303
+ L+ E++ +R EL + QL +E L E + + S
Sbjct: 1350 VSGALNEAESKTIRLSKELSSTEA--------------QLHDAQELLQEETRAKLALGSR 1395
Query: 304 CKKRAEEKKLENERMERKTHREHLLLQSDDTIQDSLHAKEEELRQRWSMYQMEVIFGKVK 363
+ E E++E + + T Q L W Q E
Sbjct: 1396 VRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQL--------SEWRRRQEE------- 1440
Query: 364 DATGTDETHSLVRRFLAQGDTFAQLETLKSENEQTLVRLKQEKQQLQRELEDLKYSGEAT 423
+A + RR + + Q K+E T+ RL++ +++LQ+EL+D
Sbjct: 1441 EAGALEAGEEARRRAAREAEALTQRLAEKTE---TVDRLERGRRRLQQELDD----ATMD 1493
Query: 424 LVSQQKLQAEAQERLKKEERRHAEAKDQLERALRAMQVAKDSLEHLASKLIHIT--VEDG 481
L Q++L + +++ +K ++ AE K + RA+ + A+ ++ + +T +E+
Sbjct: 1494 LEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEE 1553
Query: 482 RFAGKELDPQ 491
+ A +EL+ Q
Sbjct: 1554 QEAREELERQ 1563
Score = 52.8 bits (125), Expect = 9e-07
Identities = 113/524 (21%), Positives = 206/524 (39%), Gaps = 102/524 (19%)
Query: 90 ESSQWNIKKNQETISQLRKETKALELKLLDLLKGDEKVVQAVIREWKWEKPY---LKNRT 146
E+ + + ET+ +L + + L+ +L D E+ Q V K ++ + L
Sbjct: 1460 EALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEK 1519
Query: 147 GQALEHLDHRLR------EKVKQQNALRHQVVLRQRRLEELQLQHSLRLLEMAEAQNRHT 200
L ++ R R E+ + +L + Q EEL+ Q+ E+ +
Sbjct: 1520 AAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKD 1579
Query: 201 EVAKTMRNLENRLEKAQMKAQEAEHITSVYLQLKAYLMDESLNLENRLDSMEAEVVRTKH 260
+V K++ LE A+ A + L + LE+ L + E +R +
Sbjct: 1580 DVGKSVHELERACRVAEQAAND--------------LRAQVTELEDELTAAEDAKLRLEV 1625
Query: 261 ELEALHVVNQEALNARDIA----KNQL--QYLEETLVRERKKRERYISECKKRAEEKKLE 314
++AL ++ L RD A + QL Q + + R+ ++++R ++ A KKLE
Sbjct: 1626 TVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAV----AARKKLE 1681
Query: 315 NERMERKTHREHLLLQSDDTIQDSLHAKEEELRQ-RWSMYQMEVIFGKVKDATGTDETHS 373
E E K + + KEE ++Q R QM+ ++ +V+
Sbjct: 1682 GELEELKAQ-----------MASAGQGKEEAVKQLRKMQAQMKELWREVE---------- 1720
Query: 374 LVRRFLAQGDTFAQLETLKSENEQTLVRLKQEKQQLQRELEDLKYSGEATLVSQQKLQAE 433
+T E + S+N ++ RLK + ++ R E+L S A +QQ
Sbjct: 1721 ---------ETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEM 1771
Query: 434 AQE----RLKK----EERRHAEAK-DQLERALRAMQVAKDSLEHLASKLI----HITVED 480
A E L K EE+R E + QLE L Q + L KL+ +T E
Sbjct: 1772 ADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTE- 1830
Query: 481 GRFAGKELDPQADNYVPNLLGLVEEKLLKLQAQLQGHDVQEMLCHIANREFLASLEGRLP 540
A + +A++ L E ++ +L+ +L D H + +A+LE +L
Sbjct: 1831 -LSAERSFSAKAESGRQQL----ERQIQELRGRLGEEDAGARARH---KMTIAALESKLA 1882
Query: 541 EYNTRIALPLATSKDKFFDEESEEEDNEVVTRASLKIRSQKLIE 584
+ +E+ E+E E + L R++K ++
Sbjct: 1883 Q----------------AEEQLEQETRERILSGKLVRRAEKRLK 1910
Score = 52.0 bits (123), Expect = 2e-06
Identities = 78/395 (19%), Positives = 164/395 (41%), Gaps = 52/395 (13%)
Query: 103 ISQLRKETKALELKLLDLLKGDEKVVQAVIREWKWEKPYLKNRTGQALEHLDHRLREKVK 162
+++L E A E L L E VQA+ + + + + L +LR+
Sbjct: 1606 VTELEDELTAAEDAKLRL----EVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEV 1661
Query: 163 QQNALRHQVVLRQRRLEELQLQHSLRLLEMAEAQNRHTEVAKTMRNLENRLEKAQMKAQE 222
+++ R Q L ++L+ + +MA A E K +R ++ ++++ + +E
Sbjct: 1662 ERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEE 1721
Query: 223 AEHITSVYLQLKAYLMDESLNLENRLDSMEAEVVRTKHELEALHVVNQEALNARDIAKNQ 282
TS + + ++ E RL +EAEV+R + EL A ++A RD ++
Sbjct: 1722 TR--TS-----REEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADE 1774
Query: 283 L---QYLEETLVRERKKRERYISECKKRAEEKKLENERMERKTHREHLLLQSDDT---IQ 336
+ + ++ E+++ E + + ++ EE++ +E + + + L ++S T +
Sbjct: 1775 VANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAE 1834
Query: 337 DSLHAKEEELRQRWSMYQMEVIFGKV-KDATGTDETHSL----VRRFLAQGDTFAQLETL 391
S AK E RQ+ Q++ + G++ ++ G H + + LAQ + + ET
Sbjct: 1835 RSFSAKAESGRQQLER-QIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQETR 1893
Query: 392 KSENEQTLVRLKQEK-----------------------------QQLQRELEDLKYSGEA 422
+ LVR +++ +QL+R+LE+ +
Sbjct: 1894 ERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASR 1953
Query: 423 TLVSQQKLQAEAQERLKKEERRHAEAKDQLERALR 457
+++LQ E ++ + E + E R R
Sbjct: 1954 AQAGRRRLQRELEDVTESAESMNREVTTLRNRLRR 1988
Score = 50.4 bits (119), Expect = 4e-06
Identities = 85/382 (22%), Positives = 159/382 (41%), Gaps = 35/382 (9%)
Query: 67 VHSQVAELHKKIQLLEGDRKAFFESSQWNIKKNQETISQLRKETKALELKLLDLLKGDEK 126
+ +QV EL ++ E D K E + +K E Q R E + L D +
Sbjct: 1602 LRAQVTELEDELTAAE-DAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAE 1660
Query: 127 VVQAVIREWKWEKPYLKNRTGQALEHLDHRL-------REKVKQQNALRHQVVLRQRRLE 179
V + R+ + + + LE L ++ E VKQ ++ Q+ R +E
Sbjct: 1661 VERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVE 1720
Query: 180 ELQLQHSLRLLEMAEAQNRHTEVAKTMRNLENRL---EKAQMKAQE-----AEHITSVYL 231
E + + E++ R + + L+ L ++A+ +AQ+ A+ + + L
Sbjct: 1721 ETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNL 1780
Query: 232 QLKAYLMDESLNLENRLDSMEAEVVRTKHELEALH------VVNQEALNARDIAKNQLQY 285
KA +++E LE RL +E E+ + E L+ ++ E+L A+
Sbjct: 1781 S-KAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSA 1839
Query: 286 LEETLVRERKKRERYISECKKRAEEKKLENERMERKTHR--EHLLLQSDDTIQDSLHAK- 342
E+ R++ ER I E + R E+ + T E L Q+++ ++ +
Sbjct: 1840 KAES---GRQQLERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERI 1896
Query: 343 -EEELRQRWSMYQMEVIFGKVKDATGTDETHSLVRRFLAQGDT-FAQLETLKSENEQTLV 400
+L +R EV+ ++ D+ +R L +G+ QL+ E E+
Sbjct: 1897 LSGKLVRRAEKRLKEVVLQVEEERRVADQ----LRDQLEKGNLRVKQLKRQLEEAEEEAS 1952
Query: 401 RLKQEKQQLQRELEDLKYSGEA 422
R + +++LQRELED+ S E+
Sbjct: 1953 RAQAGRRRLQRELEDVTESAES 1974
>gi|32698688 citron [Homo sapiens]
Length = 2027
Score = 68.2 bits (165), Expect = 2e-11
Identities = 101/448 (22%), Positives = 189/448 (42%), Gaps = 37/448 (8%)
Query: 80 LLEGDRKAFF-ESSQWNIKKNQETISQLRKETKALELKLLDLLKGDEKVVQAVIREWKWE 138
LLE D + E S Q + +++ KAL+L L D+ + K+ + +E++ +
Sbjct: 502 LLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQL-LHDIREQSRKLQEIKEQEYQAQ 560
Query: 139 KPYLKNRTGQALEHLDHRLREKVKQQNALRH-QVVLRQRRLEELQLQHSL---------R 188
++ Q E L R ++ LR ++ + + + + QH L
Sbjct: 561 VEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKATECQHKLLKAKDQGKPE 620
Query: 189 LLEMAEAQNRHTEVAKTMRNLENRLEKAQMKAQEAEHITSVYLQLKAYLMDESLNLENRL 248
+ E A+ + + E ++ L+ +LEKA + EA + Q K E L+NR
Sbjct: 621 VGEYAKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQNRE 680
Query: 249 DSMEAEVVRTKHELEALHVVNQEALNARDIAKNQLQYLEETLVRERKKRERYISECKKRA 308
DS E + + E E L ++EA + + L+ E+ + K + I K A
Sbjct: 681 DSSEG-IRKKLVEAEELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIK--KDLA 737
Query: 309 EEKKLEN--ERMERKTHREHLLLQSDDTIQDSLHAKEEELRQRWSMYQMEVIFGKVKDAT 366
+++ LEN +R E + H + +L + +++ +K L QR ++ +A
Sbjct: 738 DKETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQR---------IVELSEAN 788
Query: 367 GTDETHSLV--RRFLAQGDTFAQLETLKSENEQTLVRLKQEKQQLQRELEDLKYSGEATL 424
SL R AQ + ++L K E +L+ + ++L+ +LE + +
Sbjct: 789 KLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDH--- 845
Query: 425 VSQQKLQAEAQERLKKEERRHAEAKDQLERALRAMQVAKDSLEHLASKLIHITVEDGRFA 484
S + E + RL++ H E K +L+R L +Q+ SL+ S+L ++ R A
Sbjct: 846 -SDKNRLLELETRLREVSLEHEEQKLELKRQLTELQL---SLQERESQL--TALQAARAA 899
Query: 485 GKELDPQADNYVPNLLGLVEEKLLKLQA 512
+ QA + EE++ L A
Sbjct: 900 LESQLRQAKTELEETTAEAEEEIQALTA 927
Score = 43.5 bits (101), Expect = 5e-04
Identities = 81/385 (21%), Positives = 163/385 (42%), Gaps = 66/385 (17%)
Query: 98 KNQETISQLRKETKALELKL------LDLLKGDEKVVQAVIREWKWEKPYLKNRTGQALE 151
+++E +L+++ L+L L L L+ +++ +R+ K E LE
Sbjct: 864 EHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTE-----------LE 912
Query: 152 HLDHRLREKVKQQNALRHQVVLRQRRLEELQLQHSLRLLEMAEAQNRHTEVAKTMRN--- 208
E+++ A R ++ QR+ + L+ ++ + ++ E N+ TE + N
Sbjct: 913 ETTAEAEEEIQALTAHRDEI---QRKFDALRNSCTV-ITDLEEQLNQLTEDNAELNNQNF 968
Query: 209 -LENRLEKAQMKAQEAEHITSVYLQLKAYLMDESLNLENRLDSMEAEVVRTKHELEALHV 267
L +L++A E + S L+ + + + L ++ +MEA ++T + V
Sbjct: 969 YLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEA--LKTTCTMLEEQV 1026
Query: 268 VNQEALNARDIAKNQLQYLEETLVRERKKRERYISECKKRAEEKKLENERMERKTHREHL 327
++ EALN + K + +++ + K + EC+ R ++ L+ E+ R
Sbjct: 1027 MDLEALNDELLEKERQWEAWRSVLGDEKSQ----FECRVRELQRMLDTEKQSRA------ 1076
Query: 328 LLQSDDTIQDSLHAKEEELRQRWS---MYQMEVIFGKVKDATGTDETHSLVRRFLAQGDT 384
++D I +S E +++ + Q + K+K + +D+ + L ++
Sbjct: 1077 --RADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKH------ 1128
Query: 385 FAQLETLKSENEQTLVRLKQEKQQLQRELEDLKYSGEATLVSQQKLQAE--------AQE 436
A LE N ++L Q+K + +REL+ +A L Q LQ QE
Sbjct: 1129 -AMLEM----NARSL----QQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQE 1179
Query: 437 RLKKEERRHAEAKDQLERALRAMQV 461
L + + E D LE L +QV
Sbjct: 1180 ALDRADLLKTERSD-LEYQLENIQV 1203
>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
Length = 2017
Score = 68.2 bits (165), Expect = 2e-11
Identities = 141/633 (22%), Positives = 250/633 (39%), Gaps = 99/633 (15%)
Query: 20 ASTPSSRVKGREASGKPSHLRGKGTAQAWTPGRSKGGSFHRGAGKPSVHSQVAELHKKIQ 79
A + ++G PS R + +P R + + +HS LHK+ Q
Sbjct: 477 ADASNGSLRGLSGQRTPSPPRRSSPGRGRSPRRGPSPACSDSSTLALIHSA---LHKR-Q 532
Query: 80 LLEGDRKAFFESSQWNIKKNQETISQLRKETKALELKLLDL------------------- 120
L D + +E+SQ + ++ +S E +ALE +L L
Sbjct: 533 LQVQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQ 592
Query: 121 ---------------LKGDEKVVQAVIREWKWEKPYLK---NRTGQALEHLDHRLREKVK 162
L +V Q E + E+ L+ + + L+ + V+
Sbjct: 593 RLRSANELLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQ 652
Query: 163 QQNALRHQVVLRQRRLEELQLQHSL---RLLEMAEAQNRHT-----------EVAKTMRN 208
+R ++ R+LE+L+ + S+ L+E+ EA +R T EVA+ +
Sbjct: 653 DGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTK 712
Query: 209 -----LENRLEKAQMKAQEAEHITSVYLQLKAYLMDESLNLENRLDSMEAEVVRTKHELE 263
+E L +++A+EA S+ K ++ESL +++LD + V + + E
Sbjct: 713 AEAGRVELELSMTKLRAEEASLQDSLS---KLSALNESL-AQDKLD-LNRLVAQLEEEKS 767
Query: 264 ALHVVNQEALNARDIAKNQLQYLEETLVRERKKRERY-----ISECKKRAEEKKLENERM 318
AL ++A +A+ + + LEE + + R+ ++E + A E++L R
Sbjct: 768 ALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRH 827
Query: 319 ERKTHREHLLLQSDDTIQDSLHAKEEELRQ--RWSMYQMEVIFGKVKDATGTDETHSLVR 376
ER +E L + L +E+EL Q R + Q+E + ++ + H+
Sbjct: 828 ERSQLQEQLA-----QLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHA--- 879
Query: 377 RFLAQGDTFAQLETLKSENEQTLVRLKQEKQQLQRELEDLKYSGEATLVSQQKLQAEAQE 436
LA A+ E E T RL+ EK+ L+ L +++ +++L+AE Q
Sbjct: 880 -GLAVQLVAAEREGRTLSEEAT--RLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQA 936
Query: 437 RLKKEERRHAEAKDQLERALRAMQVAKDSLEHLASKLIHITVEDGRFAGKELDPQADNYV 496
L +E E ++ + + A E +A KL V+ R A L Q +
Sbjct: 937 LLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKL----VQAEREAQASLREQRAAHE 992
Query: 497 PNLLGLVEEK------LLKLQAQLQGHDVQEMLCHIANREFLASLEGRLPEYNTRIALPL 550
+L L EK L +AQLQ +E E LA LE E + IA
Sbjct: 993 EDLQRLQREKEAAWRELEAERAQLQSQLQRE------QEELLARLEAEKEELSEEIAALQ 1046
Query: 551 ATSKDKFFDEESEEEDNEVVTRASLKIRSQKLI 583
+ ESE++ + + S+KL+
Sbjct: 1047 QERDEGLLLAESEKQQALSLKESEKTALSEKLM 1079
Score = 53.5 bits (127), Expect = 5e-07
Identities = 87/387 (22%), Positives = 158/387 (40%), Gaps = 50/387 (12%)
Query: 100 QETISQLRKETKALELKLLDL---LKGDEKVVQAVIREWKWEKPYLKNRTGQALEHLDHR 156
++ + LR E L+ +L L L G E+ ++ RE R +ALE
Sbjct: 819 EQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARRE--------AQRQVEALERAARE 870
Query: 157 LREKVKQQNALRHQVVLRQRRLEELQLQHSLRLLEMAEAQNRHTEVAKTMRNLENRLEKA 216
K+ L Q+V +R L + + LE + EV + + LE R E+
Sbjct: 871 KEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQL 930
Query: 217 QMKAQEA----EHITSVYLQLKAYLM--DESLNLENRLDSMEAEVVRTKHELEALHVVNQ 270
+ + Q E +T L+ ++ E +L+ L M ++V+ + E +A + Q
Sbjct: 931 EAEGQALLLAKETLTGELAGLRQQIIATQEKASLDKEL--MAQKLVQAEREAQA-SLREQ 987
Query: 271 EALNARDIAKNQLQY--------LEETLVRERKKRERYISECKKRAEEKKLENERMERKT 322
A + D+ + Q + E ++ + +RE+ + AE+++L E +
Sbjct: 988 RAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQ 1047
Query: 323 HREHLLLQSDDTIQDSLHAKEEE--------LRQRWSMYQMEVIFGKVK-DATGTDETHS 373
R+ LL ++ Q +L KE E + R S+ + + + K DA E
Sbjct: 1048 ERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDR 1107
Query: 374 LVRRFLAQGDTFAQLETLKSENEQTLVRLKQEKQQLQRELEDLKYSGEATLVSQQKLQAE 433
L ++L L+++ E+ QE ++LQ + DL ++ L E
Sbjct: 1108 STVNALT-----SELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCL-------RE 1155
Query: 434 AQERLKKEERRHAEAKDQLERALRAMQ 460
A+E L+ + R +A+D L R L Q
Sbjct: 1156 AEE-LRTQLRLLEDARDGLRRELLEAQ 1181
Score = 53.5 bits (127), Expect = 5e-07
Identities = 94/423 (22%), Positives = 183/423 (43%), Gaps = 61/423 (14%)
Query: 90 ESSQWNIKKNQETISQLRKETKALELKLLDLLKGDEKVVQAVIREWKWEKPYLKNRTGQA 149
ES + + ++ + T+ Q+ ++L+ +L EK+ + E K E K R +
Sbjct: 1586 ESVRRSERERRATLDQVATLERSLQATESELRASQEKISKMKANETKLEGD--KRRLKEV 1643
Query: 150 LEHLDHRLREKVKQQNALRHQVVLRQRRL----EELQLQHSLRLLEMAEAQNRHTEV-AK 204
L+ + R + Q+ +L + L++ RL E Q Q ++ + Q +EV A
Sbjct: 1644 LDASESRTVKLELQRRSLEGE--LQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAG 1701
Query: 205 TMRNLENRLEKAQMKAQEAEH--------ITSVYLQLKAYL---MDESLNLENRLDSMEA 253
T++ RL A K +E+E +T Q A L D++L+L+ L + E
Sbjct: 1702 TLQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEH 1761
Query: 254 EVVRTKHELEALHVVNQEALNA---------------------RDIAKNQLQYLEETLVR 292
+ + L+A EA R A+ QLQ L E L +
Sbjct: 1762 DRQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQ 1821
Query: 293 ERKKRERYISECKKRAEEKKLENERM-------------ERKTHREHLLLQSDDT-IQDS 338
++ ++ +K +E++L ER+ +R+ R L L+ D ++ +
Sbjct: 1822 RQEGEAAALNTVQKLQDERRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVALRRT 1881
Query: 339 LHAKE-EELRQRWSMYQMEVIFGKV-KDATGTDETHSLVRRFLAQGDTFAQLETLKSENE 396
L E E+LR ++ G++ + TG + + +R + Q + AQ+ L+ +
Sbjct: 1882 LDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLE--AQVVVLEQSHS 1939
Query: 397 --QTLVRLKQEKQQLQRELEDLKYSGEATLVSQQKLQAEAQERLKKEERRHAEAKDQLER 454
Q V +Q++ +LQ+E+E L+ + T + + + ++R++ E + + K QL++
Sbjct: 1940 PAQLEVDAQQQQLELQQEVERLRSAQAQTERTLEARERAHRQRVRGLEEQVSTLKGQLQQ 1999
Query: 455 ALR 457
LR
Sbjct: 2000 ELR 2002
Score = 35.0 bits (79), Expect = 0.20
Identities = 114/525 (21%), Positives = 206/525 (39%), Gaps = 54/525 (10%)
Query: 52 RSKGGSFHRGAGKPSVHSQVA-----ELHKKIQLLEGDR---KAFFESSQWNIKKNQETI 103
R + G R G+ + + EL ++ E +R K E + + +E
Sbjct: 1195 RQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEAR 1254
Query: 104 SQLRKETKALELKLLDLLKGD---EKVVQAVIREWKWEKPYLKNRTGQALEHLDHRLREK 160
+ + KE L L ++ + + +Q + R+ K R G+ L L RL
Sbjct: 1255 TAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSE-NTRLGRELAELQGRLALG 1313
Query: 161 VKQQNALRHQVV-LRQRRLE-ELQLQHSLRLLEMAEA--QNRHTEVAKTMRNLENRLEKA 216
+ + R + + LRQR L+ E L+ + L++A+ Q + E R L LE+A
Sbjct: 1314 ERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEA 1373
Query: 217 Q-MKAQEAEHITSVYLQLKAYLMDESLNLENRLDSMEAEVVRTKHELEALHVVNQEALNA 275
+ + Q+ +H + L+L+A E+ L RL + E + EL + V
Sbjct: 1374 RGTEKQQLDHARGLELKLEA-ARAEAAELGLRLSAAEGRAQGLEAELARVEV-------Q 1425
Query: 276 RDIAKNQLQYLEETLVRERKKRERYISECKKRAEEKKLENERMERKTHREHLLLQSDDTI 335
R A+ QL L L +R + A + + L S T+
Sbjct: 1426 RRAAEAQLGGLRSAL-----RRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTL 1480
Query: 336 QDSLHAKEEELRQRWSMYQMEVIFGKVKDATGT--DETHSLVR-RFLAQGDTFA---QLE 389
+ S ++ S ++ V+ A E S R R + T A QL
Sbjct: 1481 ECSPGSQPPSPGPATSPASPDLDPEAVRGALREFLQELRSAQRERDELRTQTSALNRQLA 1540
Query: 390 TLKSENEQTLVRLKQEKQQLQRELEDLKYSGEATLVSQQKLQAEAQERLKKEERRHAEAK 449
+++E + R +Q Q+ E E+ + S + L Q A +E +++ ER
Sbjct: 1541 EMEAERDSATSRARQ-LQKAVAESEEARRSVDGRLSGVQAELALQEESVRRSERERRATL 1599
Query: 450 DQ---LERALRAMQVAKDSLEHLASKLIHITVEDGRFAGKELDPQADNYVPNLLGLVEEK 506
DQ LER+L Q + L K+ + + + G + + +L E +
Sbjct: 1600 DQVATLERSL---QATESELRASQEKISKMKANETKLEGDK------RRLKEVLDASESR 1650
Query: 507 LLKLQAQ---LQGHDVQEMLCHIANREFLA-SLEGRLPEYNTRIA 547
+KL+ Q L+G ++Q +++RE A +L+ R+ ++A
Sbjct: 1651 TVKLELQRRSLEG-ELQRSRLGLSDREAQAQALQDRVDSLQRQVA 1694
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.127 0.344
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,985,838
Number of Sequences: 37866
Number of extensions: 977468
Number of successful extensions: 12196
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 262
Number of HSP's successfully gapped in prelim test: 922
Number of HSP's that attempted gapping in prelim test: 5858
Number of HSP's gapped (non-prelim): 3719
length of query: 595
length of database: 18,247,518
effective HSP length: 108
effective length of query: 487
effective length of database: 14,157,990
effective search space: 6894941130
effective search space used: 6894941130
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.