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Search of human proteins with 10864047
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|10864047 epidermal growth factor receptor pathway substrate
15-like 1 [Homo sapiens]
(864 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|10864047 epidermal growth factor receptor pathway substrate 1... 1727 0.0
gi|4503593 epidermal growth factor receptor pathway substrate 15... 709 0.0
gi|229577185 epidermal growth factor receptor pathway substrate ... 279 7e-75
gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens] 176 6e-44
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens] 176 6e-44
gi|194294523 intersectin 2 isoform 3 [Homo sapiens] 152 2e-36
gi|194294521 intersectin 2 isoform 1 [Homo sapiens] 152 2e-36
gi|194294525 intersectin 2 isoform 2 [Homo sapiens] 152 2e-36
gi|21361462 EH-domain containing 2 [Homo sapiens] 103 7e-22
gi|7657056 EH-domain containing 3 [Homo sapiens] 99 2e-20
gi|30240932 EH-domain containing 1 [Homo sapiens] 98 4e-20
gi|21264315 EH-domain containing 4 [Homo sapiens] 96 1e-19
gi|190886437 RALBP1 associated Eps domain containing 1 isoform b... 73 1e-12
gi|190886435 RALBP1 associated Eps domain containing 1 isoform a... 70 1e-11
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ... 70 1e-11
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 69 1e-11
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H... 69 2e-11
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [... 69 2e-11
gi|36031016 CTCL tumor antigen L14-2 [Homo sapiens] 68 3e-11
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 68 4e-11
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo... 68 4e-11
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo... 68 4e-11
gi|38044112 restin isoform b [Homo sapiens] 67 9e-11
gi|4506751 restin isoform a [Homo sapiens] 67 9e-11
gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens] 66 1e-10
gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens] 66 1e-10
gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens] 66 1e-10
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo... 66 1e-10
gi|156104908 myosin heavy chain 6 [Homo sapiens] 66 2e-10
gi|87298937 centrosomal protein 110kDa [Homo sapiens] 66 2e-10
>gi|10864047 epidermal growth factor receptor pathway substrate
15-like 1 [Homo sapiens]
Length = 864
Score = 1727 bits (4472), Expect = 0.0
Identities = 864/864 (100%), Positives = 864/864 (100%)
Query: 1 MAAPLIPLSQQIPTGNSLYESYYKQVDPAYTGRVGASEAALFLKKSGLSDIILGKIWDLA 60
MAAPLIPLSQQIPTGNSLYESYYKQVDPAYTGRVGASEAALFLKKSGLSDIILGKIWDLA
Sbjct: 1 MAAPLIPLSQQIPTGNSLYESYYKQVDPAYTGRVGASEAALFLKKSGLSDIILGKIWDLA 60
Query: 61 DPEGKGFLDKQGFYVALRLVACAQSGHEVTLSNLNLSMPPPKFHDTSSPLMVTPPSAEAH 120
DPEGKGFLDKQGFYVALRLVACAQSGHEVTLSNLNLSMPPPKFHDTSSPLMVTPPSAEAH
Sbjct: 61 DPEGKGFLDKQGFYVALRLVACAQSGHEVTLSNLNLSMPPPKFHDTSSPLMVTPPSAEAH 120
Query: 121 WAVRVEEKAKFDGIFESLLPINGLLSGDKVKPVLMNSKLPLDVLGRVWDLSDIDKDGHLD 180
WAVRVEEKAKFDGIFESLLPINGLLSGDKVKPVLMNSKLPLDVLGRVWDLSDIDKDGHLD
Sbjct: 121 WAVRVEEKAKFDGIFESLLPINGLLSGDKVKPVLMNSKLPLDVLGRVWDLSDIDKDGHLD 180
Query: 181 RDEFAVAMHLVYRALEKEPVPSALPPSLIPPSKRKKTVFPGAVPVLPASPPPKDSLRSTP 240
RDEFAVAMHLVYRALEKEPVPSALPPSLIPPSKRKKTVFPGAVPVLPASPPPKDSLRSTP
Sbjct: 181 RDEFAVAMHLVYRALEKEPVPSALPPSLIPPSKRKKTVFPGAVPVLPASPPPKDSLRSTP 240
Query: 241 SHGSVSSLNSTGSLSPKHSLKQTQPTVNWVVPVADKMRFDEIFLKTDLDLDGYVSGQEVK 300
SHGSVSSLNSTGSLSPKHSLKQTQPTVNWVVPVADKMRFDEIFLKTDLDLDGYVSGQEVK
Sbjct: 241 SHGSVSSLNSTGSLSPKHSLKQTQPTVNWVVPVADKMRFDEIFLKTDLDLDGYVSGQEVK 300
Query: 301 EIFMHSGLTQNLLAHIWALADTRQTGKLSKDQFALAMYFIQQKVSKGIDPPQVLSPDMVP 360
EIFMHSGLTQNLLAHIWALADTRQTGKLSKDQFALAMYFIQQKVSKGIDPPQVLSPDMVP
Sbjct: 301 EIFMHSGLTQNLLAHIWALADTRQTGKLSKDQFALAMYFIQQKVSKGIDPPQVLSPDMVP 360
Query: 361 PSERGTPGPDSSGSLGSGEFTGVKELDDISQEIAQLQREKYSLEQDIREKEEAIRQKTSE 420
PSERGTPGPDSSGSLGSGEFTGVKELDDISQEIAQLQREKYSLEQDIREKEEAIRQKTSE
Sbjct: 361 PSERGTPGPDSSGSLGSGEFTGVKELDDISQEIAQLQREKYSLEQDIREKEEAIRQKTSE 420
Query: 421 VQELQNDLDRETSSLQELEAQKQDAQDRLDEMDQQKAKLRDMLSDVRQKCQDETQMISSL 480
VQELQNDLDRETSSLQELEAQKQDAQDRLDEMDQQKAKLRDMLSDVRQKCQDETQMISSL
Sbjct: 421 VQELQNDLDRETSSLQELEAQKQDAQDRLDEMDQQKAKLRDMLSDVRQKCQDETQMISSL 480
Query: 481 KTQIQSQESDLKSQEDDLNRAKSELNRLQQEETQLEQSIQAGRVQLETIIKSLKSTQDEI 540
KTQIQSQESDLKSQEDDLNRAKSELNRLQQEETQLEQSIQAGRVQLETIIKSLKSTQDEI
Sbjct: 481 KTQIQSQESDLKSQEDDLNRAKSELNRLQQEETQLEQSIQAGRVQLETIIKSLKSTQDEI 540
Query: 541 NQARSKLSQLHESRQEAHRSLEQYDQVLDGAHGASLTDLANLSEGVSLAERGSFGAMDDP 600
NQARSKLSQLHESRQEAHRSLEQYDQVLDGAHGASLTDLANLSEGVSLAERGSFGAMDDP
Sbjct: 541 NQARSKLSQLHESRQEAHRSLEQYDQVLDGAHGASLTDLANLSEGVSLAERGSFGAMDDP 600
Query: 601 FKNKALLFSNNTQELHPDPFQTEDPFKSDPFKGADPFKGDPFQNDPFAEQQTTSTDPFGG 660
FKNKALLFSNNTQELHPDPFQTEDPFKSDPFKGADPFKGDPFQNDPFAEQQTTSTDPFGG
Sbjct: 601 FKNKALLFSNNTQELHPDPFQTEDPFKSDPFKGADPFKGDPFQNDPFAEQQTTSTDPFGG 660
Query: 661 DPFKESDPFRGSATDDFFKKQTKNDPFTSDPFTKNPSLPSKLDPFESSDPFSSSSVSSKG 720
DPFKESDPFRGSATDDFFKKQTKNDPFTSDPFTKNPSLPSKLDPFESSDPFSSSSVSSKG
Sbjct: 661 DPFKESDPFRGSATDDFFKKQTKNDPFTSDPFTKNPSLPSKLDPFESSDPFSSSSVSSKG 720
Query: 721 SDPFGTLDPFGSGSFNSAEGFADFSQMSKPPPSGPFTSSLGGAGFSDDPFKSKQDTPALP 780
SDPFGTLDPFGSGSFNSAEGFADFSQMSKPPPSGPFTSSLGGAGFSDDPFKSKQDTPALP
Sbjct: 721 SDPFGTLDPFGSGSFNSAEGFADFSQMSKPPPSGPFTSSLGGAGFSDDPFKSKQDTPALP 780
Query: 781 PKKPAPPRPKPPSGKSTPVSQLGSADFPEAPDPFQPLGADSGDPFQSKKGFGDPFSGKDP 840
PKKPAPPRPKPPSGKSTPVSQLGSADFPEAPDPFQPLGADSGDPFQSKKGFGDPFSGKDP
Sbjct: 781 PKKPAPPRPKPPSGKSTPVSQLGSADFPEAPDPFQPLGADSGDPFQSKKGFGDPFSGKDP 840
Query: 841 FVPSSAAKPSKASASGFADFTSVS 864
FVPSSAAKPSKASASGFADFTSVS
Sbjct: 841 FVPSSAAKPSKASASGFADFTSVS 864
>gi|4503593 epidermal growth factor receptor pathway substrate 15
isoform A [Homo sapiens]
Length = 896
Score = 709 bits (1829), Expect = 0.0
Identities = 415/916 (45%), Positives = 564/916 (61%), Gaps = 142/916 (15%)
Query: 11 QIPTGNSLYESYYKQVDPAYTGRVGASEAALFLKKSGLSDIILGKIWDLADPEGKGFLDK 70
Q+ +GN +YE YY+QVD TGRV AS+AA FLKKSGL D+ILGKIWDLAD +GKG L+K
Sbjct: 11 QLSSGNPVYEKYYRQVDTGNTGRVLASDAAAFLKKSGLPDLILGKIWDLADTDGKGILNK 70
Query: 71 QGFYVALRLVACAQSGHEVTLSNLNLSMPPPKFHDTSSPLMVTPPSA-EAHWAVRVEEKA 129
Q F+VALRLVACAQ+G EV+LS+LNL++PPP+FHDTSSPL+++ SA E WAV+ E+KA
Sbjct: 71 QEFFVALRLVACAQNGLEVSLSSLNLAVPPPRFHDTSSPLLISGTSAAELPWAVKPEDKA 130
Query: 130 KFDGIFESLLPINGLLSGDKVKPVLMNSKLPLDVLGRVWDLSDIDKDGHLDRDEFAVAMH 189
K+D IF+SL P+NG LSGDKVKPVL+NSKLP+D+LGRVW+LSDID DG LDRDEFAVAM
Sbjct: 131 KYDAIFDSLSPVNGFLSGDKVKPVLLNSKLPVDILGRVWELSDIDHDGMLDRDEFAVAMF 190
Query: 190 LVYRALEKEPVPSALPPSLIPPSKRKKTVFPGAVPVLPASPPPKDSLRSTPSHGSVSSLN 249
LVY ALEKEPVP +LPP+L+PPSKRK
Sbjct: 191 LVYCALEKEPVPMSLPPALVPPSKRK---------------------------------- 216
Query: 250 STGSLSPKHSLKQTQPTVNWVVPVADKMRFDEIFLKTDLDLDGYVSGQEVKEIFMHSGLT 309
WVV A+K ++DEIFLKTD D+DG+VSG EV+EIF+ +GL
Sbjct: 217 ------------------TWVVSPAEKAKYDEIFLKTDKDMDGFVSGLEVREIFLKTGLP 258
Query: 310 QNLLAHIWALADTRQTGKLSKDQFALAMYFIQQKVSKGIDPPQVLSPDMVPPSERGTPGP 369
LLAHIW+L DT+ GKLSKDQFALA + I QK+ KGIDPP VL+P+M+PPS+R +
Sbjct: 259 STLLAHIWSLCDTKDCGKLSKDQFALAFHLISQKLIKGIDPPHVLTPEMIPPSDRASLQK 318
Query: 370 DSSGSLGSGEFTGVKELDDISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLD 429
+ GS +F+ +KELD ++ EI LQREK ++EQD++EKE+ I+Q+TSEVQ+LQ+++
Sbjct: 319 NIIGSSPVADFSAIKELDTLNNEIVDLQREKNNVEQDLKEKEDTIKQRTSEVQDLQDEVQ 378
Query: 430 RETSSLQELEAQKQDAQDRLDEMDQQKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQES 489
RE ++LQ+L+AQKQ Q+ LDE+D+QKA+L + L +VR+KC +E Q+ISSLK ++ SQES
Sbjct: 379 RENTNLQKLQAQKQQVQELLDELDEQKAQLEEQLKEVRKKCAEEAQLISSLKAELTSQES 438
Query: 490 DLKSQEDDLNRAKSELNRLQQEETQLEQSIQAGRVQLETIIKSLKSTQDEINQARSKLSQ 549
+ + E++L +A+ EL+RLQQE +LE+S+++G+ QLE + + L+ +Q EI+ + KL +
Sbjct: 439 QISTYEEELAKAREELSRLQQETAELEESVESGKAQLEPLQQHLQDSQQEISSMQMKLME 498
Query: 550 ---LHESRQEAHRSLEQYDQVLDGAH-----GASLTDLANLSEGV--------------- 586
L + + + +++GA S ++ ANL+E V
Sbjct: 499 MKDLENHNSQLNWCSSPHSILVNGATDYCSLSTSSSETANLNEHVEGQSNLESEPIHQES 558
Query: 587 ---SLAERGSFGAMDDPFKNKALL------FSNNTQELHPDPFQTE-------------D 624
S E G D+ A+ NN DPF + D
Sbjct: 559 PARSSPELLPSGVTDENEVTTAVTEKVCSELDNNRHSKEEDPFNVDSSSLTGPVADTNLD 618
Query: 625 PFKSDPFKGADPFKGDPFQNDPFAEQQTTSTDPFGGDPFKESDPFRGSATDDFFKKQTKN 684
F+SDPF G+DPFK DPF DPFGGDPFK SDPF A+D FF++ T
Sbjct: 619 FFQSDPFVGSDPFKDDPF----------GKIDPFGGDPFKGSDPF---ASDCFFRQST-- 663
Query: 685 DPF---TSDPFT-KNPSLPSKLDPFESSDPFSSS----SVSSKGSDPFGTLDPFGSGSFN 736
DPF ++DPF+ N S + ++ + +DPF+ + S +DPF ++ FG+ SF
Sbjct: 664 DPFATSSTDPFSAANNSSITSVETLKHNDPFAPGGTVVAASDSATDPFASV--FGNESFG 721
Query: 737 SAEGFADFSQMSKPPPSGPFTSSLGGA---------GFSDDPFKSKQDTPALPPKKPAPP 787
GFADFS +SK PF S+ + F + KS+ + PALPPK P
Sbjct: 722 G--GFADFSTLSKVNNEDPFRSATSSSVSNVVITKNVFEETSVKSEDEPPALPPKIGTPT 779
Query: 788 RPKP-PSGKSTPVSQLGSADFPEAPDPFQPLGADSGDPFQSKKGFGDPFSGKDPFVPSSA 846
RP P P GK + +++L S D + DPFQP G+ +K DP DPF ++
Sbjct: 780 RPCPLPPGKRS-INKLDSPDPFKLNDPFQPF---PGNDSPKEK---DPEIFCDPFTSATT 832
Query: 847 AKPSKASASGFADFTS 862
+A S FA+F++
Sbjct: 833 TTNKEADPSNFANFSA 848
>gi|229577185 epidermal growth factor receptor pathway substrate 15
isoform B [Homo sapiens]
Length = 582
Score = 279 bits (714), Expect = 7e-75
Identities = 192/528 (36%), Positives = 288/528 (54%), Gaps = 89/528 (16%)
Query: 398 REKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEAQKQDAQDRLDEMDQQKA 457
REK ++EQD++EKE+ I+Q+TSEVQ+LQ+++ RE ++LQ+L+AQKQ Q+ LDE+D+QKA
Sbjct: 33 REKNNVEQDLKEKEDTIKQRTSEVQDLQDEVQRENTNLQKLQAQKQQVQELLDELDEQKA 92
Query: 458 KLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLKSQEDDLNRAKSELNRLQQEETQLEQ 517
+L + L +VR+KC +E Q+ISSLK ++ SQES + + E++L +A+ EL+RLQQE +LE+
Sbjct: 93 QLEEQLKEVRKKCAEEAQLISSLKAELTSQESQISTYEEELAKAREELSRLQQETAELEE 152
Query: 518 SIQAGRVQLETIIKSLKSTQDEINQARSKLSQ---LHESRQEAHRSLEQYDQVLDGAH-- 572
S+++G+ QLE + + L+ +Q EI+ + KL + L + + + +++GA
Sbjct: 153 SVESGKAQLEPLQQHLQDSQQEISSMQMKLMEMKDLENHNSQLNWCSSPHSILVNGATDY 212
Query: 573 ---GASLTDLANLSEGV------------------SLAERGSFGAMDDPFKNKALL---- 607
S ++ ANL+E V S E G D+ A+
Sbjct: 213 CSLSTSSSETANLNEHVEGQSNLESEPIHQESPARSSPELLPSGVTDENEVTTAVTEKVC 272
Query: 608 --FSNNTQELHPDPFQTE-------------DPFKSDPFKGADPFKGDPFQNDPFAEQQT 652
NN DPF + D F+SDPF G+DPFK DPF
Sbjct: 273 SELDNNRHSKEEDPFNVDSSSLTGPVADTNLDFFQSDPFVGSDPFKDDPF---------- 322
Query: 653 TSTDPFGGDPFKESDPFRGSATDDFFKKQTKNDPF---TSDPFT-KNPSLPSKLDPFESS 708
DPFGGDPFK SDPF A+D FF++ T DPF ++DPF+ N S + ++ + +
Sbjct: 323 GKIDPFGGDPFKGSDPF---ASDCFFRQST--DPFATSSTDPFSAANNSSITSVETLKHN 377
Query: 709 DPFSSS----SVSSKGSDPFGTLDPFGSGSFNSAEGFADFSQMSKPPPSGPFTSSLGGA- 763
DPF+ + S +DPF ++ FG+ SF GFADFS +SK PF S+ +
Sbjct: 378 DPFAPGGTVVAASDSATDPFASV--FGNESFGG--GFADFSTLSKVNNEDPFRSATSSSV 433
Query: 764 --------GFSDDPFKSKQDTPALPPKKPAPPRPKP-PSGKSTPVSQLGSADFPEAPDPF 814
F + KS+ + PALPPK P RP P P GK + +++L S D + DPF
Sbjct: 434 SNVVITKNVFEETSVKSEDEPPALPPKIGTPTRPCPLPPGKRS-INKLDSPDPFKLNDPF 492
Query: 815 QPLGADSGDPFQSKKGFGDPFSGKDPFVPSSAAKPSKASASGFADFTS 862
QP G+ +K DP DPF ++ +A S FA+F++
Sbjct: 493 QPF---PGNDSPKEK---DPEIFCDPFTSATTTTNKEADPSNFANFSA 534
>gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens]
Length = 1220
Score = 176 bits (447), Expect = 6e-44
Identities = 150/601 (24%), Positives = 257/601 (42%), Gaps = 111/601 (18%)
Query: 121 WAVRVEEKAKFDGIFESLLPINGLLSGDKVKPVLMNSKLPLDVLGRVWDLSDIDKDGHLD 180
WA+ VEE+AK D F SL PI+G ++GD+ + S LP VL ++W L+D++ DG +D
Sbjct: 15 WAITVEERAKHDQQFHSLKPISGFITGDQARNFFFQSGLPQPVLAQIWALADMNNDGRMD 74
Query: 181 RDEFAVAMHLVYRALEKEPVPSALPPSL--------------------IPPSKRKKTVFP 220
+ EF++AM L+ L+ +PSALPP + +PP V
Sbjct: 75 QVEFSIAMKLIKLKLQGYQLPSALPPVMKQQPVAISSAPAFGMGGIASMPPLTAVAPVPM 134
Query: 221 GAVPVL----------------------------------PASPPPKDSLRSTPSHGSVS 246
G++PV+ PA+ PK S S GS
Sbjct: 135 GSIPVVGMSPTLVSSVPTAAVPPLANGAPPVIQPLPAFAHPAATLPKSSSFSRSGPGS-- 192
Query: 247 SLNSTGSLSPKHSLKQTQPTVNWVVPVADKMRFDEIFLKTDLDLDGYVSGQEVKEIFMHS 306
LN+ + + P W VP + ++++ ++F D + G+++G + + I M S
Sbjct: 193 QLNTKLQKAQSFDVASVPPVAEWAVPQSSRLKYRQLFNSHDKTMSGHLTGPQARTILMQS 252
Query: 307 GLTQNLLAHIWALADTRQTGKLSKDQFALAMYFIQQKVSKGIDPPQVLSPDMVPPSERGT 366
L Q LA IW L+D Q GKL+ ++F LAM+ I +S G P VL P+ +PPS R
Sbjct: 253 SLPQAQLASIWNLSDIDQDGKLTAEEFILAMHLIDVAMS-GQPLPPVLPPEYIPPSFRRV 311
Query: 367 PGPDSSGSLGSGEF----------------------------------TGVKELDDISQE 392
+ S G EL+ Q
Sbjct: 312 RSGSGISVISSTSVDQRLPEEPVLEDEQQQLEKKLPVTFEDKKRENFERGNLELEKRRQA 371
Query: 393 IAQLQR---------EKYSLEQDIREKEEAIRQKTSEVQ---ELQNDLDRETSSLQELEA 440
+ + QR E+ E+ RE++E R++ E++ E Q +L+R+ + E
Sbjct: 372 LLEQQRKEQERLAQLERAEQERKERERQEQERKRQLELEKQLEKQRELERQREEERRKEI 431
Query: 441 QKQDAQDRLDEMDQQKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLKSQEDDLNR 500
++++A R E +Q R+ ++ + E + I LK + ++ E +L++ D ++
Sbjct: 432 ERREAAKRELERQRQLEWERNRRQELLNQRNKEQEDIVVLKAKKKTLEFELEALNDKKHQ 491
Query: 501 AKSELNRLQQEETQLEQSIQAGRVQLETIIKSLKSTQDEINQARSKLSQLHESRQEAHRS 560
+ +L ++ T Q I++ E I + Q ++ +++ L +L +Q +
Sbjct: 492 LEGKLQDIRCRLTTQRQEIESTNKSRELRIAEITHLQQQLQESQQMLGRLIPEKQILNDQ 551
Query: 561 LEQYDQVLDGAHGASLTDLANLSEGVSLAERGSFGAMDDPFK------NKALLFSNNTQE 614
L+Q Q + H SL L E LA + +D+ K + +F+N +E
Sbjct: 552 LKQVQQ--NSLHRDSLVTLKRALEAKELARQHLRDQLDEVEKETRSKLQEIDIFNNQLKE 609
Query: 615 L 615
L
Sbjct: 610 L 610
Score = 109 bits (273), Expect = 1e-23
Identities = 109/479 (22%), Positives = 206/479 (43%), Gaps = 74/479 (15%)
Query: 92 SNLNLSMPPPKFHDTSSPLMVTPPSAEAHWAVRVEEKAKFDGIFESL-LPINGLLSGDKV 150
S LN + + D +S PP AE WAV + K+ +F S ++G L+G +
Sbjct: 192 SQLNTKLQKAQSFDVAS----VPPVAE--WAVPQSSRLKYRQLFNSHDKTMSGHLTGPQA 245
Query: 151 KPVLMNSKLPLDVLGRVWDLSDIDKDGHLDRDEFAVAMHLVYRALEKEPVPSALPPSLIP 210
+ +LM S LP L +W+LSDID+DG L +EF +AMHL+ A+ +P+P LPP IP
Sbjct: 246 RTILMQSSLPQAQLASIWNLSDIDQDGKLTAEEFILAMHLIDVAMSGQPLPPVLPPEYIP 305
Query: 211 PSKRKKTVFPGAVPVLPASPPPKDSLRSTPSHGSVSSLNSTGSLSPKHSLKQTQPTVNWV 270
PS R+ +RS +SS + L + L+ Q +
Sbjct: 306 PSFRR--------------------VRSGSGISVISSTSVDQRLPEEPVLEDEQQQLEKK 345
Query: 271 VPVADKMRFDEIFLKTDLDLDGYVSGQEVKEIFMHSGLTQNLLAHIWALADTRQTGKLSK 330
+PV + + E F + +L+L+ + + + Q LA + A+ + + +
Sbjct: 346 LPVTFEDKKRENFERGNLELE-----KRRQALLEQQRKEQERLAQL-ERAEQERKERERQ 399
Query: 331 DQFALAMYFIQQKVSKGIDPPQVLSPDMVPPSERGTPGPDSSGSLGSGEFTGVKELDDIS 390
+Q +++++ K +EL+
Sbjct: 400 EQERKRQLELEKQLEK------------------------------------QRELERQR 423
Query: 391 QEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEAQKQDAQDRLD 450
+E + + E+ + E++ + + + QEL N ++E + L+A+K+ + L+
Sbjct: 424 EEERRKEIERREAAKRELERQRQLEWERNRRQELLNQRNKEQEDIVVLKAKKKTLEFELE 483
Query: 451 EMDQQKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLKSQEDDLNRAKSELNRLQQ 510
++ +K +L L D+R + + Q I S + + +++ + L ++ L RL
Sbjct: 484 ALNDKKHQLEGKLQDIRCRLTTQRQEIESTNKSRELRIAEITHLQQQLQESQQMLGRLIP 543
Query: 511 EETQLE---QSIQAGRVQLETIIKSLKSTQDEINQARSKL-SQLHESRQEAHRSLEQYD 565
E+ L + +Q + ++++ +LK + AR L QL E +E L++ D
Sbjct: 544 EKQILNDQLKQVQQNSLHRDSLV-TLKRALEAKELARQHLRDQLDEVEKETRSKLQEID 601
Score = 51.2 bits (121), Expect = 4e-06
Identities = 36/179 (20%), Positives = 86/179 (48%), Gaps = 5/179 (2%)
Query: 392 EIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEAQKQDAQDRLDE 451
E+ L +K+ LE +++ + + E++ + + + L+ Q Q++Q L
Sbjct: 481 ELEALNDKKHQLEGKLQDIRCRLTTQRQEIESTNKSRELRIAEITHLQQQLQESQQMLGR 540
Query: 452 MDQQKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQE---SDLKSQEDDLNR-AKSELNR 507
+ +K L D L V+Q +++ LK ++++E L+ Q D++ + +S+L
Sbjct: 541 LIPEKQILNDQLKQVQQNSLHRDSLVT-LKRALEAKELARQHLRDQLDEVEKETRSKLQE 599
Query: 508 LQQEETQLEQSIQAGRVQLETIIKSLKSTQDEINQARSKLSQLHESRQEAHRSLEQYDQ 566
+ QL++ + Q KS+++ + + + K+ +L + ++EA R ++ D+
Sbjct: 600 IDIFNNQLKELREIHNKQQLQKQKSMEAERLKQKEQERKIIELEKQKEEAQRRAQERDK 658
Score = 40.8 bits (94), Expect = 0.005
Identities = 47/191 (24%), Positives = 88/191 (46%), Gaps = 35/191 (18%)
Query: 395 QLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRET-----SSLQELEAQKQDAQDRL 449
QLQ + L + I EK+ + + +VQ QN L R++ +L+ E +Q +D+L
Sbjct: 530 QLQESQQMLGRLIPEKQ-ILNDQLKQVQ--QNSLHRDSLVTLKRALEAKELARQHLRDQL 586
Query: 450 DEMDQQ-KAKLRDMLSDVRQKCQDETQMISSLKTQIQSQES----------------DLK 492
DE++++ ++KL+++ D+ E + I + K Q+Q Q+S +L+
Sbjct: 587 DEVEKETRSKLQEI--DIFNNQLKELREIHN-KQQLQKQKSMEAERLKQKEQERKIIELE 643
Query: 493 SQEDDLNRAKSELNRLQQEETQLEQSIQAGR-------VQLETIIKSLKSTQDEINQARS 545
Q+++ R E ++ E Q E Q R ++ E +K + +A+
Sbjct: 644 KQKEEAQRRAQERDKQWLEHVQQEDEHQRPRKLHEEEKLKREESVKKKDGEEKGKQEAQD 703
Query: 546 KLSQLHESRQE 556
KL +L QE
Sbjct: 704 KLGRLFHQHQE 714
Score = 40.0 bits (92), Expect = 0.009
Identities = 32/138 (23%), Positives = 66/138 (47%), Gaps = 7/138 (5%)
Query: 392 EIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLD--RETSSLQELEAQKQDAQDRL 449
E +L R+ L + E E+ R K E+ N L RE + Q+L+ QK +RL
Sbjct: 573 EAKELARQH--LRDQLDEVEKETRSKLQEIDIFNNQLKELREIHNKQQLQKQKSMEAERL 630
Query: 450 DEMDQQK--AKLRDMLSDVRQKCQD-ETQMISSLKTQIQSQESDLKSQEDDLNRAKSELN 506
+ +Q++ +L + +++ Q+ + Q + ++ + + Q +E+ L R +S
Sbjct: 631 KQKEQERKIIELEKQKEEAQRRAQERDKQWLEHVQQEDEHQRPRKLHEEEKLKREESVKK 690
Query: 507 RLQQEETQLEQSIQAGRV 524
+ +E+ + E + GR+
Sbjct: 691 KDGEEKGKQEAQDKLGRL 708
Score = 38.9 bits (89), Expect = 0.021
Identities = 22/76 (28%), Positives = 36/76 (47%), Gaps = 1/76 (1%)
Query: 12 IPTGNSL-YESYYKQVDPAYTGRVGASEAALFLKKSGLSDIILGKIWDLADPEGKGFLDK 70
+P + L Y + D +G + +A L +S L L IW+L+D + G L
Sbjct: 217 VPQSSRLKYRQLFNSHDKTMSGHLTGPQARTILMQSSLPQAQLASIWNLSDIDQDGKLTA 276
Query: 71 QGFYVALRLVACAQSG 86
+ F +A+ L+ A SG
Sbjct: 277 EEFILAMHLIDVAMSG 292
>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
Length = 1721
Score = 176 bits (447), Expect = 6e-44
Identities = 150/601 (24%), Positives = 257/601 (42%), Gaps = 111/601 (18%)
Query: 121 WAVRVEEKAKFDGIFESLLPINGLLSGDKVKPVLMNSKLPLDVLGRVWDLSDIDKDGHLD 180
WA+ VEE+AK D F SL PI+G ++GD+ + S LP VL ++W L+D++ DG +D
Sbjct: 15 WAITVEERAKHDQQFHSLKPISGFITGDQARNFFFQSGLPQPVLAQIWALADMNNDGRMD 74
Query: 181 RDEFAVAMHLVYRALEKEPVPSALPPSL--------------------IPPSKRKKTVFP 220
+ EF++AM L+ L+ +PSALPP + +PP V
Sbjct: 75 QVEFSIAMKLIKLKLQGYQLPSALPPVMKQQPVAISSAPAFGMGGIASMPPLTAVAPVPM 134
Query: 221 GAVPVL----------------------------------PASPPPKDSLRSTPSHGSVS 246
G++PV+ PA+ PK S S GS
Sbjct: 135 GSIPVVGMSPTLVSSVPTAAVPPLANGAPPVIQPLPAFAHPAATLPKSSSFSRSGPGS-- 192
Query: 247 SLNSTGSLSPKHSLKQTQPTVNWVVPVADKMRFDEIFLKTDLDLDGYVSGQEVKEIFMHS 306
LN+ + + P W VP + ++++ ++F D + G+++G + + I M S
Sbjct: 193 QLNTKLQKAQSFDVASVPPVAEWAVPQSSRLKYRQLFNSHDKTMSGHLTGPQARTILMQS 252
Query: 307 GLTQNLLAHIWALADTRQTGKLSKDQFALAMYFIQQKVSKGIDPPQVLSPDMVPPSERGT 366
L Q LA IW L+D Q GKL+ ++F LAM+ I +S G P VL P+ +PPS R
Sbjct: 253 SLPQAQLASIWNLSDIDQDGKLTAEEFILAMHLIDVAMS-GQPLPPVLPPEYIPPSFRRV 311
Query: 367 PGPDSSGSLGSGEF----------------------------------TGVKELDDISQE 392
+ S G EL+ Q
Sbjct: 312 RSGSGISVISSTSVDQRLPEEPVLEDEQQQLEKKLPVTFEDKKRENFERGNLELEKRRQA 371
Query: 393 IAQLQR---------EKYSLEQDIREKEEAIRQKTSEVQ---ELQNDLDRETSSLQELEA 440
+ + QR E+ E+ RE++E R++ E++ E Q +L+R+ + E
Sbjct: 372 LLEQQRKEQERLAQLERAEQERKERERQEQERKRQLELEKQLEKQRELERQREEERRKEI 431
Query: 441 QKQDAQDRLDEMDQQKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLKSQEDDLNR 500
++++A R E +Q R+ ++ + E + I LK + ++ E +L++ D ++
Sbjct: 432 ERREAAKRELERQRQLEWERNRRQELLNQRNKEQEDIVVLKAKKKTLEFELEALNDKKHQ 491
Query: 501 AKSELNRLQQEETQLEQSIQAGRVQLETIIKSLKSTQDEINQARSKLSQLHESRQEAHRS 560
+ +L ++ T Q I++ E I + Q ++ +++ L +L +Q +
Sbjct: 492 LEGKLQDIRCRLTTQRQEIESTNKSRELRIAEITHLQQQLQESQQMLGRLIPEKQILNDQ 551
Query: 561 LEQYDQVLDGAHGASLTDLANLSEGVSLAERGSFGAMDDPFK------NKALLFSNNTQE 614
L+Q Q + H SL L E LA + +D+ K + +F+N +E
Sbjct: 552 LKQVQQ--NSLHRDSLVTLKRALEAKELARQHLRDQLDEVEKETRSKLQEIDIFNNQLKE 609
Query: 615 L 615
L
Sbjct: 610 L 610
Score = 109 bits (273), Expect = 1e-23
Identities = 109/479 (22%), Positives = 206/479 (43%), Gaps = 74/479 (15%)
Query: 92 SNLNLSMPPPKFHDTSSPLMVTPPSAEAHWAVRVEEKAKFDGIFESL-LPINGLLSGDKV 150
S LN + + D +S PP AE WAV + K+ +F S ++G L+G +
Sbjct: 192 SQLNTKLQKAQSFDVAS----VPPVAE--WAVPQSSRLKYRQLFNSHDKTMSGHLTGPQA 245
Query: 151 KPVLMNSKLPLDVLGRVWDLSDIDKDGHLDRDEFAVAMHLVYRALEKEPVPSALPPSLIP 210
+ +LM S LP L +W+LSDID+DG L +EF +AMHL+ A+ +P+P LPP IP
Sbjct: 246 RTILMQSSLPQAQLASIWNLSDIDQDGKLTAEEFILAMHLIDVAMSGQPLPPVLPPEYIP 305
Query: 211 PSKRKKTVFPGAVPVLPASPPPKDSLRSTPSHGSVSSLNSTGSLSPKHSLKQTQPTVNWV 270
PS R+ +RS +SS + L + L+ Q +
Sbjct: 306 PSFRR--------------------VRSGSGISVISSTSVDQRLPEEPVLEDEQQQLEKK 345
Query: 271 VPVADKMRFDEIFLKTDLDLDGYVSGQEVKEIFMHSGLTQNLLAHIWALADTRQTGKLSK 330
+PV + + E F + +L+L+ + + + Q LA + A+ + + +
Sbjct: 346 LPVTFEDKKRENFERGNLELE-----KRRQALLEQQRKEQERLAQL-ERAEQERKERERQ 399
Query: 331 DQFALAMYFIQQKVSKGIDPPQVLSPDMVPPSERGTPGPDSSGSLGSGEFTGVKELDDIS 390
+Q +++++ K +EL+
Sbjct: 400 EQERKRQLELEKQLEK------------------------------------QRELERQR 423
Query: 391 QEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEAQKQDAQDRLD 450
+E + + E+ + E++ + + + QEL N ++E + L+A+K+ + L+
Sbjct: 424 EEERRKEIERREAAKRELERQRQLEWERNRRQELLNQRNKEQEDIVVLKAKKKTLEFELE 483
Query: 451 EMDQQKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLKSQEDDLNRAKSELNRLQQ 510
++ +K +L L D+R + + Q I S + + +++ + L ++ L RL
Sbjct: 484 ALNDKKHQLEGKLQDIRCRLTTQRQEIESTNKSRELRIAEITHLQQQLQESQQMLGRLIP 543
Query: 511 EETQLE---QSIQAGRVQLETIIKSLKSTQDEINQARSKL-SQLHESRQEAHRSLEQYD 565
E+ L + +Q + ++++ +LK + AR L QL E +E L++ D
Sbjct: 544 EKQILNDQLKQVQQNSLHRDSLV-TLKRALEAKELARQHLRDQLDEVEKETRSKLQEID 601
Score = 51.2 bits (121), Expect = 4e-06
Identities = 36/179 (20%), Positives = 86/179 (48%), Gaps = 5/179 (2%)
Query: 392 EIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEAQKQDAQDRLDE 451
E+ L +K+ LE +++ + + E++ + + + L+ Q Q++Q L
Sbjct: 481 ELEALNDKKHQLEGKLQDIRCRLTTQRQEIESTNKSRELRIAEITHLQQQLQESQQMLGR 540
Query: 452 MDQQKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQE---SDLKSQEDDLNR-AKSELNR 507
+ +K L D L V+Q +++ LK ++++E L+ Q D++ + +S+L
Sbjct: 541 LIPEKQILNDQLKQVQQNSLHRDSLVT-LKRALEAKELARQHLRDQLDEVEKETRSKLQE 599
Query: 508 LQQEETQLEQSIQAGRVQLETIIKSLKSTQDEINQARSKLSQLHESRQEAHRSLEQYDQ 566
+ QL++ + Q KS+++ + + + K+ +L + ++EA R ++ D+
Sbjct: 600 IDIFNNQLKELREIHNKQQLQKQKSMEAERLKQKEQERKIIELEKQKEEAQRRAQERDK 658
Score = 40.8 bits (94), Expect = 0.005
Identities = 47/191 (24%), Positives = 88/191 (46%), Gaps = 35/191 (18%)
Query: 395 QLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRET-----SSLQELEAQKQDAQDRL 449
QLQ + L + I EK+ + + +VQ QN L R++ +L+ E +Q +D+L
Sbjct: 530 QLQESQQMLGRLIPEKQ-ILNDQLKQVQ--QNSLHRDSLVTLKRALEAKELARQHLRDQL 586
Query: 450 DEMDQQ-KAKLRDMLSDVRQKCQDETQMISSLKTQIQSQES----------------DLK 492
DE++++ ++KL+++ D+ E + I + K Q+Q Q+S +L+
Sbjct: 587 DEVEKETRSKLQEI--DIFNNQLKELREIHN-KQQLQKQKSMEAERLKQKEQERKIIELE 643
Query: 493 SQEDDLNRAKSELNRLQQEETQLEQSIQAGR-------VQLETIIKSLKSTQDEINQARS 545
Q+++ R E ++ E Q E Q R ++ E +K + +A+
Sbjct: 644 KQKEEAQRRAQERDKQWLEHVQQEDEHQRPRKLHEEEKLKREESVKKKDGEEKGKQEAQD 703
Query: 546 KLSQLHESRQE 556
KL +L QE
Sbjct: 704 KLGRLFHQHQE 714
Score = 40.0 bits (92), Expect = 0.009
Identities = 32/138 (23%), Positives = 66/138 (47%), Gaps = 7/138 (5%)
Query: 392 EIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLD--RETSSLQELEAQKQDAQDRL 449
E +L R+ L + E E+ R K E+ N L RE + Q+L+ QK +RL
Sbjct: 573 EAKELARQH--LRDQLDEVEKETRSKLQEIDIFNNQLKELREIHNKQQLQKQKSMEAERL 630
Query: 450 DEMDQQK--AKLRDMLSDVRQKCQD-ETQMISSLKTQIQSQESDLKSQEDDLNRAKSELN 506
+ +Q++ +L + +++ Q+ + Q + ++ + + Q +E+ L R +S
Sbjct: 631 KQKEQERKIIELEKQKEEAQRRAQERDKQWLEHVQQEDEHQRPRKLHEEEKLKREESVKK 690
Query: 507 RLQQEETQLEQSIQAGRV 524
+ +E+ + E + GR+
Sbjct: 691 KDGEEKGKQEAQDKLGRL 708
Score = 38.9 bits (89), Expect = 0.021
Identities = 22/76 (28%), Positives = 36/76 (47%), Gaps = 1/76 (1%)
Query: 12 IPTGNSL-YESYYKQVDPAYTGRVGASEAALFLKKSGLSDIILGKIWDLADPEGKGFLDK 70
+P + L Y + D +G + +A L +S L L IW+L+D + G L
Sbjct: 217 VPQSSRLKYRQLFNSHDKTMSGHLTGPQARTILMQSSLPQAQLASIWNLSDIDQDGKLTA 276
Query: 71 QGFYVALRLVACAQSG 86
+ F +A+ L+ A SG
Sbjct: 277 EEFILAMHLIDVAMSG 292
>gi|194294523 intersectin 2 isoform 3 [Homo sapiens]
Length = 1670
Score = 152 bits (383), Expect = 2e-36
Identities = 142/545 (26%), Positives = 244/545 (44%), Gaps = 106/545 (19%)
Query: 121 WAVRVEEKAKFDGIFESLLPINGLLSGDKVKPVLMNSKLPLDVLGRVWDLSDIDKDGHLD 180
WA+ EE+ K D F++L P G ++GD+ + + S LP VL +W LSD++KDG +D
Sbjct: 16 WAITSEERTKHDRQFDNLKPSGGYITGDQARNFFLQSGLPAPVLAEIWALSDLNKDGKMD 75
Query: 181 RDEFAVAMHLVYRALEKEPVPSALP----------------------------------- 205
+ EF++AM L+ L+ + +P LP
Sbjct: 76 QQEFSIAMKLIKLKLQGQQLPVVLPPIMKQPPMFSPLISARFGMGSMPNLSIPQPLPPAA 135
Query: 206 --------------PSLIPPSKRKKTVFPGAVPVLPAS---PPPKDSLRSTPSHGSVSSL 248
P L+ P+ +V ++P AS P P ST HGS SL
Sbjct: 136 PITSLSSATSGTNLPPLMMPTPLVPSVSTSSLPNGTASLIQPLPIPYSSSTLPHGSSYSL 195
Query: 249 -------------------NSTGSLSPKHSLKQTQP---TVNWVVPVADKMRFDEIFLKT 286
S+ S S SL P T W VP ++++ + F
Sbjct: 196 MMGGFGGASIQKAQSLIDLGSSSSTSSTASLSGNSPKTGTSEWAVPQPTRLKYRQKFNTL 255
Query: 287 DLDLDGYVSGQEVKEIFMHSGLTQNLLAHIWALADTRQTGKLSKDQFALAMYFIQQKVSK 346
D + GY+SG + + + S L+Q LA IW LAD G+L ++F LAM+ +
Sbjct: 256 DKSMSGYLSGFQARNALLQSNLSQTQLATIWTLADVDGDGQLKAEEFILAMH-LTDMAKA 314
Query: 347 GIDPPQVLSPDMVPPSERGTPGPDS-SGSLGS----GEFTGVKELDDISQEIAQLQREKY 401
G P L P++VPPS RG DS +G+L S E K+L ++ + E+
Sbjct: 315 GQPLPLTLPPELVPPSFRGGKQIDSINGTLPSYQKMQEEEPQKKLPVTFEDKRKANYERG 374
Query: 402 SLEQDIREK---EEAIRQKTSEVQELQNDLDRETSSLQELEAQKQ-DAQDRLD---EMDQ 454
++E + R + E+ R+ + Q+ + + +R+ LQE E +KQ + + RL+ E+++
Sbjct: 375 NMELEKRRQALMEQQQREAERKAQKEKEEWERKQRELQEQEWKKQLELEKRLEKQRELER 434
Query: 455 QKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLKSQEDDLNRAKSELNRLQQEETQ 514
Q+ + R + R+ + E + L+ + + + +L +Q+ NR + E+ RL ++
Sbjct: 435 QREEERRKDIERREAAKQELERQRRLEWE-RIRRQELLNQK---NREQEEIVRLNSKKKN 490
Query: 515 LEQSIQA---------GRVQLETIIKSLKSTQDEI--NQARSKLSQLHESRQEAHRSLEQ 563
L ++A GR+Q + K + T+ E+ Q ++ ++ + +QE L++
Sbjct: 491 LHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQQE----LQE 546
Query: 564 YDQVL 568
Y L
Sbjct: 547 YQNKL 551
Score = 75.1 bits (183), Expect = 3e-13
Identities = 39/103 (37%), Positives = 58/103 (56%), Gaps = 1/103 (0%)
Query: 113 TPPSAEAHWAVRVEEKAKFDGIFESL-LPINGLLSGDKVKPVLMNSKLPLDVLGRVWDLS 171
+P + + WAV + K+ F +L ++G LSG + + L+ S L L +W L+
Sbjct: 230 SPKTGTSEWAVPQPTRLKYRQKFNTLDKSMSGYLSGFQARNALLQSNLSQTQLATIWTLA 289
Query: 172 DIDKDGHLDRDEFAVAMHLVYRALEKEPVPSALPPSLIPPSKR 214
D+D DG L +EF +AMHL A +P+P LPP L+PPS R
Sbjct: 290 DVDGDGQLKAEEFILAMHLTDMAKAGQPLPLTLPPELVPPSFR 332
Score = 48.1 bits (113), Expect = 3e-05
Identities = 43/200 (21%), Positives = 85/200 (42%), Gaps = 32/200 (16%)
Query: 391 QEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEAQKQDAQDRLD 450
++I + + K LE+ R + E IR+ QEL N +RE + L ++K++ L+
Sbjct: 442 KDIERREAAKQELERQRRLEWERIRR-----QELLNQKNREQEEIVRLNSKKKNLHLELE 496
Query: 451 EMDQQKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLKSQEDDL------------ 498
++ + ++ L DVR K Q + + L Q + ++K + +L
Sbjct: 497 ALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVP 556
Query: 499 ---------------NRAKSELNRLQQEETQLEQSIQAGRVQLETIIKSLKSTQDEINQA 543
N S ++ L ++ + E+ Q + QL+ + K S E++
Sbjct: 557 EKQLLNERIKNMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQLDALEKETASKLSEMDSF 616
Query: 544 RSKLSQLHESRQEAHRSLEQ 563
++L +L E+ +LEQ
Sbjct: 617 NNQLKELRETYNTQQLALEQ 636
Score = 45.1 bits (105), Expect = 3e-04
Identities = 27/85 (31%), Positives = 43/85 (50%), Gaps = 1/85 (1%)
Query: 19 YESYYKQVDPAYTGRVGASEAALFLKKSGLSDIILGKIWDLADPEGKGFLDKQGFYVALR 78
Y + +D + +G + +A L +S LS L IW LAD +G G L + F +A+
Sbjct: 248 YRQKFNTLDKSMSGYLSGFQARNALLQSNLSQTQLATIWTLADVDGDGQLKAEEFILAMH 307
Query: 79 LVACAQSGHEVTLSNLNLSMPPPKF 103
L A++G + L+ L + PP F
Sbjct: 308 LTDMAKAGQPLPLT-LPPELVPPSF 331
>gi|194294521 intersectin 2 isoform 1 [Homo sapiens]
Length = 1697
Score = 152 bits (383), Expect = 2e-36
Identities = 142/545 (26%), Positives = 244/545 (44%), Gaps = 106/545 (19%)
Query: 121 WAVRVEEKAKFDGIFESLLPINGLLSGDKVKPVLMNSKLPLDVLGRVWDLSDIDKDGHLD 180
WA+ EE+ K D F++L P G ++GD+ + + S LP VL +W LSD++KDG +D
Sbjct: 16 WAITSEERTKHDRQFDNLKPSGGYITGDQARNFFLQSGLPAPVLAEIWALSDLNKDGKMD 75
Query: 181 RDEFAVAMHLVYRALEKEPVPSALP----------------------------------- 205
+ EF++AM L+ L+ + +P LP
Sbjct: 76 QQEFSIAMKLIKLKLQGQQLPVVLPPIMKQPPMFSPLISARFGMGSMPNLSIPQPLPPAA 135
Query: 206 --------------PSLIPPSKRKKTVFPGAVPVLPAS---PPPKDSLRSTPSHGSVSSL 248
P L+ P+ +V ++P AS P P ST HGS SL
Sbjct: 136 PITSLSSATSGTNLPPLMMPTPLVPSVSTSSLPNGTASLIQPLPIPYSSSTLPHGSSYSL 195
Query: 249 -------------------NSTGSLSPKHSLKQTQP---TVNWVVPVADKMRFDEIFLKT 286
S+ S S SL P T W VP ++++ + F
Sbjct: 196 MMGGFGGASIQKAQSLIDLGSSSSTSSTASLSGNSPKTGTSEWAVPQPTRLKYRQKFNTL 255
Query: 287 DLDLDGYVSGQEVKEIFMHSGLTQNLLAHIWALADTRQTGKLSKDQFALAMYFIQQKVSK 346
D + GY+SG + + + S L+Q LA IW LAD G+L ++F LAM+ +
Sbjct: 256 DKSMSGYLSGFQARNALLQSNLSQTQLATIWTLADVDGDGQLKAEEFILAMH-LTDMAKA 314
Query: 347 GIDPPQVLSPDMVPPSERGTPGPDS-SGSLGS----GEFTGVKELDDISQEIAQLQREKY 401
G P L P++VPPS RG DS +G+L S E K+L ++ + E+
Sbjct: 315 GQPLPLTLPPELVPPSFRGGKQIDSINGTLPSYQKMQEEEPQKKLPVTFEDKRKANYERG 374
Query: 402 SLEQDIREK---EEAIRQKTSEVQELQNDLDRETSSLQELEAQKQ-DAQDRLD---EMDQ 454
++E + R + E+ R+ + Q+ + + +R+ LQE E +KQ + + RL+ E+++
Sbjct: 375 NMELEKRRQALMEQQQREAERKAQKEKEEWERKQRELQEQEWKKQLELEKRLEKQRELER 434
Query: 455 QKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLKSQEDDLNRAKSELNRLQQEETQ 514
Q+ + R + R+ + E + L+ + + + +L +Q+ NR + E+ RL ++
Sbjct: 435 QREEERRKDIERREAAKQELERQRRLEWE-RIRRQELLNQK---NREQEEIVRLNSKKKN 490
Query: 515 LEQSIQA---------GRVQLETIIKSLKSTQDEI--NQARSKLSQLHESRQEAHRSLEQ 563
L ++A GR+Q + K + T+ E+ Q ++ ++ + +QE L++
Sbjct: 491 LHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQQE----LQE 546
Query: 564 YDQVL 568
Y L
Sbjct: 547 YQNKL 551
Score = 75.1 bits (183), Expect = 3e-13
Identities = 39/103 (37%), Positives = 58/103 (56%), Gaps = 1/103 (0%)
Query: 113 TPPSAEAHWAVRVEEKAKFDGIFESL-LPINGLLSGDKVKPVLMNSKLPLDVLGRVWDLS 171
+P + + WAV + K+ F +L ++G LSG + + L+ S L L +W L+
Sbjct: 230 SPKTGTSEWAVPQPTRLKYRQKFNTLDKSMSGYLSGFQARNALLQSNLSQTQLATIWTLA 289
Query: 172 DIDKDGHLDRDEFAVAMHLVYRALEKEPVPSALPPSLIPPSKR 214
D+D DG L +EF +AMHL A +P+P LPP L+PPS R
Sbjct: 290 DVDGDGQLKAEEFILAMHLTDMAKAGQPLPLTLPPELVPPSFR 332
Score = 47.8 bits (112), Expect = 4e-05
Identities = 49/209 (23%), Positives = 92/209 (44%), Gaps = 23/209 (11%)
Query: 391 QEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEAQKQDAQDRLD 450
++I + + K LE+ R + E IR+ QEL N +RE + L ++K++ L+
Sbjct: 442 KDIERREAAKQELERQRRLEWERIRR-----QELLNQKNREQEEIVRLNSKKKNLHLELE 496
Query: 451 EMDQQKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLKSQEDDLNRAKSELNRLQQ 510
++ + ++ L DVR K Q + + L Q + ++K + +L +++L L
Sbjct: 497 ALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVP 556
Query: 511 EETQLEQSIQAGRVQLETIIKSLKSTQDEINQARSKLSQLHESRQEAHRSLEQYDQVLDG 570
E+ L + IK+++ + N S +S LH+ E ++ + LD
Sbjct: 557 EKQLLNER-----------IKNMQFS----NTPDSGVSLLHKKSLEKEELCQRLKEQLDA 601
Query: 571 AHGASLTDLANLSEGVSLAERGSFGAMDD 599
+ + LSE S + G MDD
Sbjct: 602 LEKET---ASKLSEMDSFNNQLKCGNMDD 627
Score = 45.1 bits (105), Expect = 3e-04
Identities = 27/85 (31%), Positives = 43/85 (50%), Gaps = 1/85 (1%)
Query: 19 YESYYKQVDPAYTGRVGASEAALFLKKSGLSDIILGKIWDLADPEGKGFLDKQGFYVALR 78
Y + +D + +G + +A L +S LS L IW LAD +G G L + F +A+
Sbjct: 248 YRQKFNTLDKSMSGYLSGFQARNALLQSNLSQTQLATIWTLADVDGDGQLKAEEFILAMH 307
Query: 79 LVACAQSGHEVTLSNLNLSMPPPKF 103
L A++G + L+ L + PP F
Sbjct: 308 LTDMAKAGQPLPLT-LPPELVPPSF 331
Score = 39.3 bits (90), Expect = 0.016
Identities = 33/176 (18%), Positives = 86/176 (48%), Gaps = 4/176 (2%)
Query: 389 ISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEAQKQDAQDR 448
IS + ++ +K + + ++ ++ + E+++LQ +L + L L +KQ +R
Sbjct: 505 ISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNER 564
Query: 449 LDEMDQQKAKLRDM-LSDVRQKCQDETQMISSLKTQIQSQESDLKSQEDDLNRAKSELNR 507
+ M Q + D +S + +K ++ ++ LK Q+ + E + S+ +++ ++L
Sbjct: 565 IKNM--QFSNTPDSGVSLLHKKSLEKEELCQRLKEQLDALEKETASKLSEMDSFNNQLKC 622
Query: 508 LQQEETQLEQSIQAGRVQLETIIKSLKSTQDEINQARSKLSQLHESRQEAHRSLEQ 563
+++ L Q + + L + LK ++ N + L QL++ +++ + +E+
Sbjct: 623 GNMDDSVL-QCLLSLLSCLNNLFLLLKELRETYNTQQLALEQLYKIKRDKLKEIER 677
>gi|194294525 intersectin 2 isoform 2 [Homo sapiens]
Length = 1249
Score = 152 bits (383), Expect = 2e-36
Identities = 142/545 (26%), Positives = 244/545 (44%), Gaps = 106/545 (19%)
Query: 121 WAVRVEEKAKFDGIFESLLPINGLLSGDKVKPVLMNSKLPLDVLGRVWDLSDIDKDGHLD 180
WA+ EE+ K D F++L P G ++GD+ + + S LP VL +W LSD++KDG +D
Sbjct: 16 WAITSEERTKHDRQFDNLKPSGGYITGDQARNFFLQSGLPAPVLAEIWALSDLNKDGKMD 75
Query: 181 RDEFAVAMHLVYRALEKEPVPSALP----------------------------------- 205
+ EF++AM L+ L+ + +P LP
Sbjct: 76 QQEFSIAMKLIKLKLQGQQLPVVLPPIMKQPPMFSPLISARFGMGSMPNLSIPQPLPPAA 135
Query: 206 --------------PSLIPPSKRKKTVFPGAVPVLPAS---PPPKDSLRSTPSHGSVSSL 248
P L+ P+ +V ++P AS P P ST HGS SL
Sbjct: 136 PITSLSSATSGTNLPPLMMPTPLVPSVSTSSLPNGTASLIQPLPIPYSSSTLPHGSSYSL 195
Query: 249 -------------------NSTGSLSPKHSLKQTQP---TVNWVVPVADKMRFDEIFLKT 286
S+ S S SL P T W VP ++++ + F
Sbjct: 196 MMGGFGGASIQKAQSLIDLGSSSSTSSTASLSGNSPKTGTSEWAVPQPTRLKYRQKFNTL 255
Query: 287 DLDLDGYVSGQEVKEIFMHSGLTQNLLAHIWALADTRQTGKLSKDQFALAMYFIQQKVSK 346
D + GY+SG + + + S L+Q LA IW LAD G+L ++F LAM+ +
Sbjct: 256 DKSMSGYLSGFQARNALLQSNLSQTQLATIWTLADVDGDGQLKAEEFILAMH-LTDMAKA 314
Query: 347 GIDPPQVLSPDMVPPSERGTPGPDS-SGSLGS----GEFTGVKELDDISQEIAQLQREKY 401
G P L P++VPPS RG DS +G+L S E K+L ++ + E+
Sbjct: 315 GQPLPLTLPPELVPPSFRGGKQIDSINGTLPSYQKMQEEEPQKKLPVTFEDKRKANYERG 374
Query: 402 SLEQDIREK---EEAIRQKTSEVQELQNDLDRETSSLQELEAQKQ-DAQDRLD---EMDQ 454
++E + R + E+ R+ + Q+ + + +R+ LQE E +KQ + + RL+ E+++
Sbjct: 375 NMELEKRRQALMEQQQREAERKAQKEKEEWERKQRELQEQEWKKQLELEKRLEKQRELER 434
Query: 455 QKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLKSQEDDLNRAKSELNRLQQEETQ 514
Q+ + R + R+ + E + L+ + + + +L +Q+ NR + E+ RL ++
Sbjct: 435 QREEERRKDIERREAAKQELERQRRLEWE-RIRRQELLNQK---NREQEEIVRLNSKKKN 490
Query: 515 LEQSIQA---------GRVQLETIIKSLKSTQDEI--NQARSKLSQLHESRQEAHRSLEQ 563
L ++A GR+Q + K + T+ E+ Q ++ ++ + +QE L++
Sbjct: 491 LHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQQE----LQE 546
Query: 564 YDQVL 568
Y L
Sbjct: 547 YQNKL 551
Score = 75.1 bits (183), Expect = 3e-13
Identities = 39/103 (37%), Positives = 58/103 (56%), Gaps = 1/103 (0%)
Query: 113 TPPSAEAHWAVRVEEKAKFDGIFESL-LPINGLLSGDKVKPVLMNSKLPLDVLGRVWDLS 171
+P + + WAV + K+ F +L ++G LSG + + L+ S L L +W L+
Sbjct: 230 SPKTGTSEWAVPQPTRLKYRQKFNTLDKSMSGYLSGFQARNALLQSNLSQTQLATIWTLA 289
Query: 172 DIDKDGHLDRDEFAVAMHLVYRALEKEPVPSALPPSLIPPSKR 214
D+D DG L +EF +AMHL A +P+P LPP L+PPS R
Sbjct: 290 DVDGDGQLKAEEFILAMHLTDMAKAGQPLPLTLPPELVPPSFR 332
Score = 47.8 bits (112), Expect = 4e-05
Identities = 49/209 (23%), Positives = 92/209 (44%), Gaps = 23/209 (11%)
Query: 391 QEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEAQKQDAQDRLD 450
++I + + K LE+ R + E IR+ QEL N +RE + L ++K++ L+
Sbjct: 442 KDIERREAAKQELERQRRLEWERIRR-----QELLNQKNREQEEIVRLNSKKKNLHLELE 496
Query: 451 EMDQQKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLKSQEDDLNRAKSELNRLQQ 510
++ + ++ L DVR K Q + + L Q + ++K + +L +++L L
Sbjct: 497 ALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVP 556
Query: 511 EETQLEQSIQAGRVQLETIIKSLKSTQDEINQARSKLSQLHESRQEAHRSLEQYDQVLDG 570
E+ L + IK+++ + N S +S LH+ E ++ + LD
Sbjct: 557 EKQLLNER-----------IKNMQFS----NTPDSGVSLLHKKSLEKEELCQRLKEQLDA 601
Query: 571 AHGASLTDLANLSEGVSLAERGSFGAMDD 599
+ + LSE S + G MDD
Sbjct: 602 LEKET---ASKLSEMDSFNNQLKCGNMDD 627
Score = 45.1 bits (105), Expect = 3e-04
Identities = 27/85 (31%), Positives = 43/85 (50%), Gaps = 1/85 (1%)
Query: 19 YESYYKQVDPAYTGRVGASEAALFLKKSGLSDIILGKIWDLADPEGKGFLDKQGFYVALR 78
Y + +D + +G + +A L +S LS L IW LAD +G G L + F +A+
Sbjct: 248 YRQKFNTLDKSMSGYLSGFQARNALLQSNLSQTQLATIWTLADVDGDGQLKAEEFILAMH 307
Query: 79 LVACAQSGHEVTLSNLNLSMPPPKF 103
L A++G + L+ L + PP F
Sbjct: 308 LTDMAKAGQPLPLT-LPPELVPPSF 331
Score = 39.3 bits (90), Expect = 0.016
Identities = 33/176 (18%), Positives = 86/176 (48%), Gaps = 4/176 (2%)
Query: 389 ISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEAQKQDAQDR 448
IS + ++ +K + + ++ ++ + E+++LQ +L + L L +KQ +R
Sbjct: 505 ISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNER 564
Query: 449 LDEMDQQKAKLRDM-LSDVRQKCQDETQMISSLKTQIQSQESDLKSQEDDLNRAKSELNR 507
+ M Q + D +S + +K ++ ++ LK Q+ + E + S+ +++ ++L
Sbjct: 565 IKNM--QFSNTPDSGVSLLHKKSLEKEELCQRLKEQLDALEKETASKLSEMDSFNNQLKC 622
Query: 508 LQQEETQLEQSIQAGRVQLETIIKSLKSTQDEINQARSKLSQLHESRQEAHRSLEQ 563
+++ L Q + + L + LK ++ N + L QL++ +++ + +E+
Sbjct: 623 GNMDDSVL-QCLLSLLSCLNNLFLLLKELRETYNTQQLALEQLYKIKRDKLKEIER 677
>gi|21361462 EH-domain containing 2 [Homo sapiens]
Length = 543
Score = 103 bits (257), Expect = 7e-22
Identities = 50/98 (51%), Positives = 69/98 (70%), Gaps = 1/98 (1%)
Query: 118 EAHWAVRVEEKAKFDGIFESLLPINGLLSGDKVKPVLMNSKLPLDVLGRVWDLSDIDKDG 177
EA W V ++K+K+D IF +L P +G LSG K K ++ +KLP VLGR+W LSD+D+DG
Sbjct: 441 EAEWVV-TKDKSKYDEIFYNLAPADGKLSGSKAKTWMVGTKLPNSVLGRIWKLSDVDRDG 499
Query: 178 HLDRDEFAVAMHLVYRALEKEPVPSALPPSLIPPSKRK 215
LD +EFA+A HL+ LE +P+ LP L+PPSKR+
Sbjct: 500 MLDDEEFALASHLIEAKLEGHGLPANLPRRLVPPSKRR 537
Score = 58.9 bits (141), Expect = 2e-08
Identities = 37/100 (37%), Positives = 55/100 (55%), Gaps = 3/100 (3%)
Query: 269 WVVPVADKMRFDEIFLKTDLDLDGYVSGQEVKEIFMHSGLTQNLLAHIWALADTRQTGKL 328
WVV DK ++DEIF DG +SG + K + + L ++L IW L+D + G L
Sbjct: 444 WVV-TKDKSKYDEIFYNL-APADGKLSGSKAKTWMVGTKLPNSVLGRIWKLSDVDRDGML 501
Query: 329 SKDQFALAMYFIQQKVSKGIDPPQVLSPDMVPPSERGTPG 368
++FALA + I+ K+ +G P L +VPPS+R G
Sbjct: 502 DDEEFALASHLIEAKL-EGHGLPANLPRRLVPPSKRRHKG 540
Score = 45.8 bits (107), Expect = 2e-04
Identities = 25/86 (29%), Positives = 45/86 (52%), Gaps = 1/86 (1%)
Query: 17 SLYESYYKQVDPAYTGRVGASEAALFLKKSGLSDIILGKIWDLADPEGKGFLDKQGFYVA 76
S Y+ + + PA G++ S+A ++ + L + +LG+IW L+D + G LD + F +A
Sbjct: 451 SKYDEIFYNLAPA-DGKLSGSKAKTWMVGTKLPNSVLGRIWKLSDVDRDGMLDDEEFALA 509
Query: 77 LRLVACAQSGHEVTLSNLNLSMPPPK 102
L+ GH + + +PP K
Sbjct: 510 SHLIEAKLEGHGLPANLPRRLVPPSK 535
>gi|7657056 EH-domain containing 3 [Homo sapiens]
Length = 535
Score = 98.6 bits (244), Expect = 2e-20
Identities = 48/98 (48%), Positives = 66/98 (67%), Gaps = 1/98 (1%)
Query: 118 EAHWAVRVEEKAKFDGIFESLLPINGLLSGDKVKPVLMNSKLPLDVLGRVWDLSDIDKDG 177
+A W V +K +D IF +L P++G ++G K ++ SKLP VLG++W L+DIDKDG
Sbjct: 436 DAEWVV-ARDKPMYDEIFYTLSPVDGKITGANAKKEMVRSKLPNSVLGKIWKLADIDKDG 494
Query: 178 HLDRDEFAVAMHLVYRALEKEPVPSALPPSLIPPSKRK 215
LD DEFA+A HL+ LE +P+ LP L+PPSKRK
Sbjct: 495 MLDDDEFALANHLIKVKLEGHELPNELPAHLLPPSKRK 532
Score = 62.0 bits (149), Expect = 2e-09
Identities = 38/96 (39%), Positives = 56/96 (58%), Gaps = 3/96 (3%)
Query: 269 WVVPVADKMRFDEIFLKTDLDLDGYVSGQEVKEIFMHSGLTQNLLAHIWALADTRQTGKL 328
WVV DK +DEIF T +DG ++G K+ + S L ++L IW LAD + G L
Sbjct: 439 WVV-ARDKPMYDEIFY-TLSPVDGKITGANAKKEMVRSKLPNSVLGKIWKLADIDKDGML 496
Query: 329 SKDQFALAMYFIQQKVSKGIDPPQVLSPDMVPPSER 364
D+FALA + I+ K+ +G + P L ++PPS+R
Sbjct: 497 DDDEFALANHLIKVKL-EGHELPNELPAHLLPPSKR 531
Score = 45.1 bits (105), Expect = 3e-04
Identities = 26/85 (30%), Positives = 42/85 (49%), Gaps = 1/85 (1%)
Query: 18 LYESYYKQVDPAYTGRVGASEAALFLKKSGLSDIILGKIWDLADPEGKGFLDKQGFYVAL 77
+Y+ + + P G++ + A + +S L + +LGKIW LAD + G LD F +A
Sbjct: 447 MYDEIFYTLSPV-DGKITGANAKKEMVRSKLPNSVLGKIWKLADIDKDGMLDDDEFALAN 505
Query: 78 RLVACAQSGHEVTLSNLNLSMPPPK 102
L+ GHE+ +PP K
Sbjct: 506 HLIKVKLEGHELPNELPAHLLPPSK 530
>gi|30240932 EH-domain containing 1 [Homo sapiens]
Length = 534
Score = 97.8 bits (242), Expect = 4e-20
Identities = 46/98 (46%), Positives = 67/98 (68%), Gaps = 1/98 (1%)
Query: 118 EAHWAVRVEEKAKFDGIFESLLPINGLLSGDKVKPVLMNSKLPLDVLGRVWDLSDIDKDG 177
+ W V ++K +D IF +L P+NG ++G K ++ SKLP VLG++W L+D+DKDG
Sbjct: 436 DVEWVVG-KDKPTYDEIFYTLSPVNGKITGANAKKEMVKSKLPNTVLGKIWKLADVDKDG 494
Query: 178 HLDRDEFAVAMHLVYRALEKEPVPSALPPSLIPPSKRK 215
LD +EFA+A HL+ LE +P+ LPP L+PPSKR+
Sbjct: 495 LLDDEEFALANHLIKVKLEGHELPADLPPHLVPPSKRR 532
Score = 62.0 bits (149), Expect = 2e-09
Identities = 39/98 (39%), Positives = 57/98 (58%), Gaps = 3/98 (3%)
Query: 267 VNWVVPVADKMRFDEIFLKTDLDLDGYVSGQEVKEIFMHSGLTQNLLAHIWALADTRQTG 326
V WVV DK +DEIF T ++G ++G K+ + S L +L IW LAD + G
Sbjct: 437 VEWVVG-KDKPTYDEIFY-TLSPVNGKITGANAKKEMVKSKLPNTVLGKIWKLADVDKDG 494
Query: 327 KLSKDQFALAMYFIQQKVSKGIDPPQVLSPDMVPPSER 364
L ++FALA + I+ K+ +G + P L P +VPPS+R
Sbjct: 495 LLDDEEFALANHLIKVKL-EGHELPADLPPHLVPPSKR 531
Score = 47.8 bits (112), Expect = 4e-05
Identities = 27/84 (32%), Positives = 42/84 (50%), Gaps = 1/84 (1%)
Query: 19 YESYYKQVDPAYTGRVGASEAALFLKKSGLSDIILGKIWDLADPEGKGFLDKQGFYVALR 78
Y+ + + P G++ + A + KS L + +LGKIW LAD + G LD + F +A
Sbjct: 448 YDEIFYTLSPV-NGKITGANAKKEMVKSKLPNTVLGKIWKLADVDKDGLLDDEEFALANH 506
Query: 79 LVACAQSGHEVTLSNLNLSMPPPK 102
L+ GHE+ +PP K
Sbjct: 507 LIKVKLEGHELPADLPPHLVPPSK 530
>gi|21264315 EH-domain containing 4 [Homo sapiens]
Length = 541
Score = 95.9 bits (237), Expect = 1e-19
Identities = 47/98 (47%), Positives = 65/98 (66%), Gaps = 1/98 (1%)
Query: 118 EAHWAVRVEEKAKFDGIFESLLPINGLLSGDKVKPVLMNSKLPLDVLGRVWDLSDIDKDG 177
E W V ++K +D +F +L PING +SG K ++ SKLP VLG++W L+D D DG
Sbjct: 439 EEEWVV-AKDKPVYDELFYTLSPINGKISGVNAKKEMVTSKLPNSVLGKIWKLADCDCDG 497
Query: 178 HLDRDEFAVAMHLVYRALEKEPVPSALPPSLIPPSKRK 215
LD +EFA+A HL+ L+ +PS+LPP L+PPS RK
Sbjct: 498 MLDEEEFALAKHLIKIKLDGYELPSSLPPHLVPPSHRK 535
Score = 60.8 bits (146), Expect = 5e-09
Identities = 38/96 (39%), Positives = 55/96 (57%), Gaps = 3/96 (3%)
Query: 269 WVVPVADKMRFDEIFLKTDLDLDGYVSGQEVKEIFMHSGLTQNLLAHIWALADTRQTGKL 328
WVV DK +DE+F T ++G +SG K+ + S L ++L IW LAD G L
Sbjct: 442 WVV-AKDKPVYDELFY-TLSPINGKISGVNAKKEMVTSKLPNSVLGKIWKLADCDCDGML 499
Query: 329 SKDQFALAMYFIQQKVSKGIDPPQVLSPDMVPPSER 364
+++FALA + I+ K+ G + P L P +VPPS R
Sbjct: 500 DEEEFALAKHLIKIKLD-GYELPSSLPPHLVPPSHR 534
Score = 43.9 bits (102), Expect = 6e-04
Identities = 30/95 (31%), Positives = 46/95 (48%), Gaps = 9/95 (9%)
Query: 18 LYESYYKQVDPAYTGRVGASEAALFLKKSGLSDIILGKIWDLADPEGKGFLDKQGFYVAL 77
+Y+ + + P G++ A + S L + +LGKIW LAD + G LD++ F +A
Sbjct: 450 VYDELFYTLSPI-NGKISGVNAKKEMVTSKLPNSVLGKIWKLADCDCDGMLDEEEFALAK 508
Query: 78 RLVACAQSGHEVTLSNLNLSMPP---PKFHDTSSP 109
L+ G+E L S+PP P H S P
Sbjct: 509 HLIKIKLDGYE-----LPSSLPPHLVPPSHRKSLP 538
>gi|190886437 RALBP1 associated Eps domain containing 1 isoform b
[Homo sapiens]
Length = 769
Score = 73.2 bits (178), Expect = 1e-12
Identities = 77/274 (28%), Positives = 109/274 (39%), Gaps = 35/274 (12%)
Query: 121 WAVRVEEKAKFDGIFESLLP-INGLLSGDKVKPVLMNSKLPLDVLGRVWDLSDIDKDGHL 179
W + E++ + F+++ P +NG + G K SKLP+ L +W+LSD DKDG L
Sbjct: 279 WKITDEQRQYYVNQFKTIQPDLNGFIPGSAAKEFFTKSKLPILELSHIWELSDFDKDGAL 338
Query: 180 DRDEFAVAMHLVYRALEKEPVPSALPPSLIP-----PSKRKKTVFPGAVPV--LPASPPP 232
DEF A HLV +P LP SL+P PG V PA PP
Sbjct: 339 TLDEFCAAFHLVVARKNGYDLPEKLPESLMPKLIDLEDSADVGDQPGEVGYSGSPAEAPP 398
Query: 233 KDSLRSTPSHGSVSSLNSTGSLSPKHSLKQTQPTVNWVVPV---ADKMRFDEIFLK-TDL 288
S S+ SLN T P+ + + VP+ K+ E+ LK T
Sbjct: 399 SKS-------PSMPSLNQTW---PELNQSSEDTAIVHPVPIRMTPSKIHMQEMELKRTGS 448
Query: 289 DLDGYVSGQEVK--EIFMHSGLTQNLLAHIWALADTRQTGKLSKDQFA-----LAMYFIQ 341
D S VK ++ + + ++ +A +T G S D F + +
Sbjct: 449 DHTNPTSPLLVKPSDLLEENKINSSVK---FASGNTVADGYSSSDSFTSDPEQIGSNVTR 505
Query: 342 QKVSKGIDPPQVLSPDMVPPSERGTPGPDSSGSL 375
Q+ G P P PP R P S SL
Sbjct: 506 QRSHSGTSPDNTAPP---PPPPRPQPSHSRSSSL 536
Score = 61.6 bits (148), Expect = 3e-09
Identities = 79/373 (21%), Positives = 146/373 (39%), Gaps = 48/373 (12%)
Query: 19 YESYYKQVDPAYTGRVGASEAALFLKKSGL--SDIILGKIWDLADPEGKGFLDKQGFYVA 76
Y + D T +V + L L ++ +D++L +I +L G+ + FY+A
Sbjct: 14 YSDLFSYCDIESTKKVVVNGRVLELFRAAQLPNDVVL-QIMELCGATRLGYFGRSQFYIA 72
Query: 77 LRLVACAQSGHEVTLSNLNL--SMPPPKFHDTSSPLMVTPPSAEAHWAVRVEEKAKFDGI 134
L+LVA AQSG + + ++N +P P+F + + E+ A ++ G
Sbjct: 73 LKLVAVAQSGFPLRVESINTVKDLPLPRF-------VASKNEQESRHAASYSSDSENQGS 125
Query: 135 FESLLP--------INGLLSGDKVKP-VLMNSKLPLDVLGRVWDLSDIDKDGHLDRDEFA 185
+ ++P G +S D V+P +++ P + +
Sbjct: 126 YSGVIPPPPGRGQVKKGSVSHDTVQPRTSADAQEPASPV--------VSPQQSPPTSPHT 177
Query: 186 VAMHLVYRALEKEPVPSALPPSLIPP-------SKRKKTVFPGAVPVLP-------ASPP 231
H + + P A P P S V+ G P P A P
Sbjct: 178 WRKHSRHPSGGNSERPLAGPGPFWSPFGEAQSGSSAGDAVWSGHSPPPPQENWVSFADTP 237
Query: 232 PKDSLRS--TPSHGSVSSLNSTGSLSPKHSLKQTQPTVN--WVVPVADKMRFDEIFLKTD 287
P +L + S +++ + S + +++ + + W + + + F
Sbjct: 238 PTSTLLTMHPASVQDQTTVRTVASATTAIEIRRQSSSYDDPWKITDEQRQYYVNQFKTIQ 297
Query: 288 LDLDGYVSGQEVKEIFMHSGLTQNLLAHIWALADTRQTGKLSKDQFALAMYFIQQKVSKG 347
DL+G++ G KE F S L L+HIW L+D + G L+ D+F A + + + G
Sbjct: 298 PDLNGFIPGSAAKEFFTKSKLPILELSHIWELSDFDKDGALTLDEFCAAFHLVVAR-KNG 356
Query: 348 IDPPQVLSPDMVP 360
D P+ L ++P
Sbjct: 357 YDLPEKLPESLMP 369
>gi|190886435 RALBP1 associated Eps domain containing 1 isoform a
[Homo sapiens]
Length = 795
Score = 69.7 bits (169), Expect = 1e-11
Identities = 35/91 (38%), Positives = 49/91 (53%), Gaps = 1/91 (1%)
Query: 121 WAVRVEEKAKFDGIFESLLP-INGLLSGDKVKPVLMNSKLPLDVLGRVWDLSDIDKDGHL 179
W + E++ + F+++ P +NG + G K SKLP+ L +W+LSD DKDG L
Sbjct: 279 WKITDEQRQYYVNQFKTIQPDLNGFIPGSAAKEFFTKSKLPILELSHIWELSDFDKDGAL 338
Query: 180 DRDEFAVAMHLVYRALEKEPVPSALPPSLIP 210
DEF A HLV +P LP SL+P
Sbjct: 339 TLDEFCAAFHLVVARKNGYDLPEKLPESLMP 369
Score = 61.6 bits (148), Expect = 3e-09
Identities = 79/373 (21%), Positives = 146/373 (39%), Gaps = 48/373 (12%)
Query: 19 YESYYKQVDPAYTGRVGASEAALFLKKSGL--SDIILGKIWDLADPEGKGFLDKQGFYVA 76
Y + D T +V + L L ++ +D++L +I +L G+ + FY+A
Sbjct: 14 YSDLFSYCDIESTKKVVVNGRVLELFRAAQLPNDVVL-QIMELCGATRLGYFGRSQFYIA 72
Query: 77 LRLVACAQSGHEVTLSNLNL--SMPPPKFHDTSSPLMVTPPSAEAHWAVRVEEKAKFDGI 134
L+LVA AQSG + + ++N +P P+F + + E+ A ++ G
Sbjct: 73 LKLVAVAQSGFPLRVESINTVKDLPLPRF-------VASKNEQESRHAASYSSDSENQGS 125
Query: 135 FESLLPI--------NGLLSGDKVKP-VLMNSKLPLDVLGRVWDLSDIDKDGHLDRDEFA 185
+ ++P G +S D V+P +++ P + +
Sbjct: 126 YSGVIPPPPGRGQVKKGSVSHDTVQPRTSADAQEPASPV--------VSPQQSPPTSPHT 177
Query: 186 VAMHLVYRALEKEPVPSALPPSLIPP-------SKRKKTVFPGAVPVLP-------ASPP 231
H + + P A P P S V+ G P P A P
Sbjct: 178 WRKHSRHPSGGNSERPLAGPGPFWSPFGEAQSGSSAGDAVWSGHSPPPPQENWVSFADTP 237
Query: 232 PKDSLRST--PSHGSVSSLNSTGSLSPKHSLKQTQPTVN--WVVPVADKMRFDEIFLKTD 287
P +L + S +++ + S + +++ + + W + + + F
Sbjct: 238 PTSTLLTMHPASVQDQTTVRTVASATTAIEIRRQSSSYDDPWKITDEQRQYYVNQFKTIQ 297
Query: 288 LDLDGYVSGQEVKEIFMHSGLTQNLLAHIWALADTRQTGKLSKDQFALAMYFIQQKVSKG 347
DL+G++ G KE F S L L+HIW L+D + G L+ D+F A + + + G
Sbjct: 298 PDLNGFIPGSAAKEFFTKSKLPILELSHIWELSDFDKDGALTLDEFCAAFHLVVAR-KNG 356
Query: 348 IDPPQVLSPDMVP 360
D P+ L ++P
Sbjct: 357 YDLPEKLPESLMP 369
>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
sapiens]
Length = 1939
Score = 69.7 bits (169), Expect = 1e-11
Identities = 50/210 (23%), Positives = 107/210 (50%), Gaps = 22/210 (10%)
Query: 384 KELDDISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEAQKQ 443
K++DD+ +A++++EK++ E ++ + ++ + + E L +E +LQE Q
Sbjct: 956 KDIDDLELTLAKVEKEKHATENKVKN----LTEEMAGLDETIAKLTKEKKALQEAHQQTL 1011
Query: 444 D----AQDRLDEMDQQKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLKSQED--- 496
D +D+++ + + K KL + D+ + E ++ L+ + E DLK ++
Sbjct: 1012 DDLQMEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKLAQESTM 1071
Query: 497 DLNRAKSELN-RLQQEETQLE------QSIQAGRVQLETIIKSLKS----TQDEINQARS 545
D K +LN +L+++E ++ + QA +QL+ IK L++ ++EI R+
Sbjct: 1072 DTENDKQQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEELEEEIEAERA 1131
Query: 546 KLSQLHESRQEAHRSLEQYDQVLDGAHGAS 575
++ + R + R LE+ + L+ A GA+
Sbjct: 1132 SRAKAEKQRSDLSRELEEISERLEEAGGAT 1161
Score = 55.1 bits (131), Expect = 3e-07
Identities = 38/200 (19%), Positives = 98/200 (49%), Gaps = 21/200 (10%)
Query: 384 KELDDISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEAQKQ 443
KE+ ++ +E + + E E +E EE + E +LQ + E +L
Sbjct: 851 KEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADALA------- 903
Query: 444 DAQDRLDEMDQQKAKLRDMLSDVRQKCQDETQM---ISSLKTQIQSQESDLKSQEDDL-- 498
DA++R D++ + K +L + +V ++ +DE ++ +++ K +++ + S+LK DDL
Sbjct: 904 DAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLEL 963
Query: 499 ---------NRAKSELNRLQQEETQLEQSIQAGRVQLETIIKSLKSTQDEINQARSKLSQ 549
+ ++++ L +E L+++I + + + ++ + T D++ K++
Sbjct: 964 TLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQMEEDKVNT 1023
Query: 550 LHESRQEAHRSLEQYDQVLD 569
L +++ + + ++ + L+
Sbjct: 1024 LTKAKTKLEQQVDDLEGSLE 1043
Score = 52.0 bits (123), Expect = 2e-06
Identities = 46/209 (22%), Positives = 97/209 (46%), Gaps = 28/209 (13%)
Query: 385 ELDDISQEIAQLQREKYSLEQDIREKEEAI---RQKTSEVQELQNDLDRETSSLQELEAQ 441
+++D QLQ++ L+ I E EE I R ++ ++ ++DL RE + E +
Sbjct: 1097 KIEDEQALAIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEE 1156
Query: 442 KQDAQDRLDEMDQQK-AKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLKSQEDDLNR 500
A EM++++ A+ + M D+ + ++L+ + ++L Q D L R
Sbjct: 1157 AGGATSAQIEMNKKREAEFQKMRRDLEESTLQHEATAAALRKKHADSVAELGEQIDSLQR 1216
Query: 501 AKSELNRLQQEETQLEQSIQAGRVQLETIIKS-----------------LKSTQDE---- 539
K +L++E+++L+ I +ET+ K+ +K+ ++E
Sbjct: 1217 VKQ---KLEKEKSELKMEINDLASNMETVSKAKANFEKMCRTLEDQLSEIKTKEEEQQRL 1273
Query: 540 INQARSKLSQLHESRQEAHRSLEQYDQVL 568
IN+ ++ ++LH E R L++ D ++
Sbjct: 1274 INELSAQKARLHTESGEFSRQLDEKDAMV 1302
Score = 52.0 bits (123), Expect = 2e-06
Identities = 42/200 (21%), Positives = 90/200 (45%), Gaps = 22/200 (11%)
Query: 385 ELDDISQEIAQLQREKYSLEQDIREKEEA---IRQKTSEVQELQNDLDRETSSLQ----E 437
E++D++ + + + K + E+ R E+ I+ K E Q L N+L + + L E
Sbjct: 1231 EINDLASNMETVSKAKANFEKMCRTLEDQLSEIKTKEEEQQRLINELSAQKARLHTESGE 1290
Query: 438 LEAQKQDAQDRLDEMDQQKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQESD---LKSQ 494
Q + + ++ + K + +++++ ++ET+ S+L +QS D L+ Q
Sbjct: 1291 FSRQLDEKDAMVSQLSRGKQAFTQQIEELKRQLEEETKAKSTLAHALQSARHDCDLLREQ 1350
Query: 495 EDDLNRAKSELNR--------LQQEETQLEQSIQAGRVQLE----TIIKSLKSTQDEINQ 542
++ AK+EL R + Q T+ E +LE + + L+ ++ +
Sbjct: 1351 YEEEQEAKAELQRGMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEA 1410
Query: 543 ARSKLSQLHESRQEAHRSLE 562
SK + L +++Q +E
Sbjct: 1411 VNSKCASLEKTKQRLQNEVE 1430
Score = 48.9 bits (115), Expect = 2e-05
Identities = 40/202 (19%), Positives = 88/202 (43%), Gaps = 21/202 (10%)
Query: 386 LDDISQEIAQLQREKYSLEQDIRE------KEEAI--------RQKTSEVQELQNDLDRE 431
L D + QL + K LE I+E EE I R+ E EL+ D+D
Sbjct: 902 LADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDL 961
Query: 432 TSSLQELEAQKQDAQDRLDEMDQQKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDL 491
+L ++E +K ++++ + ++ A L + ++ + T+ +L+ Q DL
Sbjct: 962 ELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKL-------TKEKKALQEAHQQTLDDL 1014
Query: 492 KSQEDDLNRAKSELNRLQQEETQLEQSIQAGRVQLETIIKSLKSTQDEINQARSKLSQLH 551
+ +ED +N +L+Q+ LE S++ + + ++ + + ++ A+
Sbjct: 1015 QMEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKLAQESTMDTE 1074
Query: 552 ESRQEAHRSLEQYDQVLDGAHG 573
+Q+ + L++ + + G
Sbjct: 1075 NDKQQLNEKLKKKEFEMSNLQG 1096
Score = 48.9 bits (115), Expect = 2e-05
Identities = 41/182 (22%), Positives = 77/182 (42%), Gaps = 14/182 (7%)
Query: 388 DISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEAQKQDAQD 447
D Q +L+ K L Q +++ EE + S+ L+ R + +++L + +
Sbjct: 1382 DAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLMIDVERSNA 1441
Query: 448 RLDEMDQQKAKLRDMLSDVRQKCQDETQMIS-------SLKTQIQSQESDLKSQEDDLNR 500
+D+++ +L++ +QK ++ + SL T++ ++ + D L
Sbjct: 1442 ACIALDKKQRNFDKVLAEWKQKYEETQAELEASQKESRSLSTELFKVKNAYEESLDHLET 1501
Query: 501 AKSELNRLQQEETQLEQSIQAGRVQLETIIKSLKSTQDEINQARSKLSQLHESRQEAHRS 560
K E LQQE + L + I G + + K K E S+L S +EA S
Sbjct: 1502 LKRENKNLQQEISDLTEQIAEGGKHIHELEKVKKQLDHE-------KSELQTSLEEAEAS 1554
Query: 561 LE 562
LE
Sbjct: 1555 LE 1556
Score = 47.0 bits (110), Expect = 8e-05
Identities = 43/225 (19%), Positives = 106/225 (47%), Gaps = 29/225 (12%)
Query: 384 KELDDISQEIAQ-------LQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQ 436
+++DD+ + Q L+R K LE D++ +E+ ++ Q+L L ++ +
Sbjct: 1033 QQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKLAQESTMDTENDKQQLNEKLKKKEFEMS 1092
Query: 437 ELEAQKQDAQDRLDEMDQQKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLKSQED 496
L+ + +D Q ++ ++ +L+ + ++ ++ + E + + + + Q SDL + +
Sbjct: 1093 NLQGKIEDEQALAIQLQKKIKELQARIEELEEEIEAE----RASRAKAEKQRSDLSRELE 1148
Query: 497 DLNR----------AKSELNRLQQEETQ-LEQSIQAGRVQLETIIKSLKSTQDEINQARS 545
+++ A+ E+N+ ++ E Q + + ++ +Q E +L+ + + +
Sbjct: 1149 EISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEESTLQHEATAAALRKKHAD---SVA 1205
Query: 546 KLSQLHESRQEAHRSLEQYDQVLDGAHGASLTDLANLSEGVSLAE 590
+L + +S Q + LE+ L + DLA+ E VS A+
Sbjct: 1206 ELGEQIDSLQRVKQKLEKEKSELK----MEINDLASNMETVSKAK 1246
Score = 46.2 bits (108), Expect = 1e-04
Identities = 39/203 (19%), Positives = 89/203 (43%), Gaps = 8/203 (3%)
Query: 372 SGSLGSGEFTGVKELDDISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQ---NDL 428
S SL + F ++ + L+RE +L+Q+I + E I + + EL+ L
Sbjct: 1478 SRSLSTELFKVKNAYEESLDHLETLKRENKNLQQEISDLTEQIAEGGKHIHELEKVKKQL 1537
Query: 429 DRETSSLQ-ELEAQKQDAQDRLDEMDQQKAKLRDMLSDVRQKCQDETQMISSLKTQ---- 483
D E S LQ LE + + ++ + + +L + S++ +K ++ + + LK
Sbjct: 1538 DHEKSELQTSLEEAEASLEHEEGKILRIQLELNQVKSEIDRKIAEKDEELDQLKRNHLRV 1597
Query: 484 IQSQESDLKSQEDDLNRAKSELNRLQQEETQLEQSIQAGRVQLETIIKSLKSTQDEINQA 543
++S +S L ++ N A +++ + ++E + Q +++L++TQ +
Sbjct: 1598 VESMQSTLDAEIRSRNDALRIKKKMEGDLNEMEIQLNHANRQAAEALRNLRNTQGILKDT 1657
Query: 544 RSKLSQLHESRQEAHRSLEQYDQ 566
+ L + + L ++
Sbjct: 1658 QLHLDDAIRGQDDLKEQLAMVER 1680
Score = 45.8 bits (107), Expect = 2e-04
Identities = 34/171 (19%), Positives = 87/171 (50%), Gaps = 19/171 (11%)
Query: 420 EVQELQNDLDRETSSLQELEAQKQDAQDRLDEMDQQKAKLR-------DMLSDVRQKCQD 472
E+ ++ + ++ L + EA++++ ++++ + Q+K L+ D L+D ++C
Sbjct: 852 EMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADALADAEERCD- 910
Query: 473 ETQMISSLKTQIQSQESDLKSQEDDLNRAKSEL----NRLQQEETQLEQSIQAGRVQLET 528
Q+I + K Q++++ ++ + +D +EL +L+ E ++L++ I + L
Sbjct: 911 --QLIKT-KIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAK 967
Query: 529 IIKSLKSTQDEINQARSKLSQLHESRQEAHRSLEQYDQVLDGAHGASLTDL 579
+ K +T++++ +++ L E+ + L + + L AH +L DL
Sbjct: 968 VEKEKHATENKVKNLTEEMAGLDETIAK----LTKEKKALQEAHQQTLDDL 1014
Score = 45.8 bits (107), Expect = 2e-04
Identities = 63/293 (21%), Positives = 109/293 (37%), Gaps = 80/293 (27%)
Query: 377 SGEFTGVKELDDISQEIAQLQREKYSLEQDIREKEEAIRQKTS----------------- 419
SGEF+ ++LD+ ++QL R K + Q I E + + ++T
Sbjct: 1288 SGEFS--RQLDEKDAMVSQLSRGKQAFTQQIEELKRQLEEETKAKSTLAHALQSARHDCD 1345
Query: 420 -------EVQELQNDLDRETSSLQELEAQ-----KQDAQDRLDEMDQQKAKLRDMLSDVR 467
E QE + +L R S AQ + DA R +E+++ K KL L D
Sbjct: 1346 LLREQYEEEQEAKAELQRGMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAE 1405
Query: 468 QKCQDETQMISSL---KTQIQSQESDLKSQEDDLNRA----------------------- 501
+ + +SL K ++Q++ DL + N A
Sbjct: 1406 EHVEAVNSKCASLEKTKQRLQNEVEDLMIDVERSNAACIALDKKQRNFDKVLAEWKQKYE 1465
Query: 502 --KSELNRLQQEETQL-------EQSIQAGRVQLETIIKSLKSTQDEINQARSKLS---- 548
++EL Q+E L + + + LET+ + K+ Q EI+ +++
Sbjct: 1466 ETQAELEASQKESRSLSTELFKVKNAYEESLDHLETLKRENKNLQQEISDLTEQIAEGGK 1525
Query: 549 ----------QLHESRQEAHRSLEQYDQVLDGAHGASLTDLANLSEGVSLAER 591
QL + E SLE+ + L+ G L L++ S +R
Sbjct: 1526 HIHELEKVKKQLDHEKSELQTSLEEAEASLEHEEGKILRIQLELNQVKSEIDR 1578
Score = 45.8 bits (107), Expect = 2e-04
Identities = 37/210 (17%), Positives = 85/210 (40%), Gaps = 14/210 (6%)
Query: 382 GVKELDDISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEAQ 441
G K + ++ + QL EK L+ + E E ++ + ++ +Q +L++ S + A+
Sbjct: 1523 GGKHIHELEKVKKQLDHEKSELQTSLEEAEASLEHEEGKILRIQLELNQVKSEIDRKIAE 1582
Query: 442 KQDAQDRLDEMDQQKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLKSQEDDLNRA 501
K +E+DQ K ++ ++ E + + + E DL E LN A
Sbjct: 1583 KD------EELDQLKRNHLRVVESMQSTLDAEIRSRNDALRIKKKMEGDLNEMEIQLNHA 1636
Query: 502 KSELNRLQQEETQLEQSIQAGRVQLETIIKSLKSTQDEINQARSKLSQLHESRQEAHRSL 561
+ + + ++ ++ L+ I+ ++++ + + + +E SL
Sbjct: 1637 NRQAAEALRNLRNTQGILKDTQLHLDDAIRGQDDLKEQLAMVERRANLMQAEVEELRASL 1696
Query: 562 EQYD--------QVLDGAHGASLTDLANLS 583
E+ + ++LD + L N S
Sbjct: 1697 ERTERGRKMAEQELLDASERVQLLHTQNTS 1726
Score = 45.1 bits (105), Expect = 3e-04
Identities = 35/207 (16%), Positives = 101/207 (48%), Gaps = 22/207 (10%)
Query: 384 KELDDISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEAQKQ 443
K+ + + +A+ +++ + ++ ++ R ++E+ +++N + L+ L+ + +
Sbjct: 1448 KKQRNFDKVLAEWKQKYEETQAELEASQKESRSLSTELFKVKNAYEESLDHLETLKRENK 1507
Query: 444 DAQDRLDEMDQQKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLKSQED------- 496
+ Q + ++ +Q A+ + ++ + + S L+T ++ E+ L+ +E
Sbjct: 1508 NLQQEISDLTEQIAEGGKHIHELEKVKKQLDHEKSELQTSLEEAEASLEHEEGKILRIQL 1567
Query: 497 DLNRAKSELNR-LQQEETQLEQ-------SIQAGRVQLETIIKS-------LKSTQDEIN 541
+LN+ KSE++R + +++ +L+Q +++ + L+ I+S K + ++N
Sbjct: 1568 ELNQVKSEIDRKIAEKDEELDQLKRNHLRVVESMQSTLDAEIRSRNDALRIKKKMEGDLN 1627
Query: 542 QARSKLSQLHESRQEAHRSLEQYDQVL 568
+ +L+ + EA R+L +L
Sbjct: 1628 EMEIQLNHANRQAAEALRNLRNTQGIL 1654
Score = 41.6 bits (96), Expect = 0.003
Identities = 45/231 (19%), Positives = 106/231 (45%), Gaps = 26/231 (11%)
Query: 384 KELDDISQE-IAQLQREKYSLEQDIREKEEAIRQKT------SEVQELQNDLDRETS--- 433
+ELD + + + ++ + +L+ +IR + +A+R K +E++ N +R+ +
Sbjct: 1585 EELDQLKRNHLRVVESMQSTLDAEIRSRNDALRIKKKMEGDLNEMEIQLNHANRQAAEAL 1644
Query: 434 -SLQELEAQKQDAQDRLDEMDQQKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLK 492
+L+ + +D Q LD+ + + L++ L+ V ++ + L+ ++ E K
Sbjct: 1645 RNLRNTQGILKDTQLHLDDAIRGQDDLKEQLAMVERRANLMQAEVEELRASLERTERGRK 1704
Query: 493 SQEDDLNRAKSELNRLQQEET-------QLEQSIQAGRVQLETIIKSLKSTQDEINQARS 545
E +L A + L + T +LE I + ++E I++ ++ +++ +A +
Sbjct: 1705 MAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIVQEARNAEEKAKKAIT 1764
Query: 546 KLSQLHE---SRQEAHRSLEQYDQVLDGAHGASLTDL-ANLSEGVSLAERG 592
+ + E Q+ LE+ + ++ ++ DL L E LA +G
Sbjct: 1765 DAAMMAEELKKEQDTSAHLERMKKNME----QTVKDLQLRLDEAEQLALKG 1811
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 69.3 bits (168), Expect = 1e-11
Identities = 58/254 (22%), Positives = 124/254 (48%), Gaps = 26/254 (10%)
Query: 387 DDISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEAQ-KQDA 445
DD+ + + +L++ K +LEQ + E + + E+Q ++ R ++Q ++AQ ++D
Sbjct: 1521 DDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDL 1580
Query: 446 QDRLDEMDQQKAKLRDMLSDVRQKCQDETQ---MISSLKTQIQSQESDLKSQEDDLNRAK 502
Q R ++ +++K L + ++ + +DE + + + K +++ DL++Q + N+A+
Sbjct: 1581 QTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKAR 1640
Query: 503 SE----LNRLQQEETQLEQSIQAGRVQLETII-------KSLKSTQDEINQARSKLSQLH 551
E L +LQ + ++ ++ R + I K LKS + EI Q + +L+
Sbjct: 1641 DEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSE 1700
Query: 552 ESRQEAHRSLEQY-DQVLDGAHGAS-LTD--------LANLSEGVSLAERGSFGAMDDPF 601
+R+ A + ++ D++ + A G S L D +A L E + E+ + ++D F
Sbjct: 1701 RARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELE-EEQSNMELLNDRF 1759
Query: 602 KNKALLFSNNTQEL 615
+ L EL
Sbjct: 1760 RKTTLQVDTLNAEL 1773
Score = 65.1 bits (157), Expect = 3e-10
Identities = 38/200 (19%), Positives = 103/200 (51%), Gaps = 3/200 (1%)
Query: 385 ELDDISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEAQKQD 444
E ++ ++ +A+++ ++ + D+ E+ + + E+++ + LD ET+ LQ+ Q +
Sbjct: 1017 EEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQD---QIAE 1073
Query: 445 AQDRLDEMDQQKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLKSQEDDLNRAKSE 504
Q ++DE+ Q AK + L + DET ++ ++ ++ + ++D K+
Sbjct: 1074 LQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKAS 1133
Query: 505 LNRLQQEETQLEQSIQAGRVQLETIIKSLKSTQDEINQARSKLSQLHESRQEAHRSLEQY 564
N+ ++++ L + ++A + +LE + + + Q+ + ++++L ++ +E ++ E
Sbjct: 1134 RNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQ 1193
Query: 565 DQVLDGAHGASLTDLANLSE 584
Q + H +L +L+ E
Sbjct: 1194 IQDMRQRHATALEELSEQLE 1213
Score = 58.9 bits (141), Expect = 2e-08
Identities = 52/207 (25%), Positives = 98/207 (47%), Gaps = 13/207 (6%)
Query: 386 LDDISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEAQKQDA 445
L+++S+++ Q +R K +LE++ + E ++ EV+ LQ ++L+AQ Q+
Sbjct: 1205 LEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQEL 1264
Query: 446 QDRLDEMDQQKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLKSQEDDLNRAKSEL 505
++ E D +LR L++ K Q+E +S+L + + + L +
Sbjct: 1265 HAKVSEGD----RLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDT 1320
Query: 506 NRLQQEETQLEQSIQAGRVQLETIIKSLKSTQDEINQARSKL--------SQLHESRQEA 557
L QEET+ + ++ + QLE SL+ Q+E +AR L SQL +++++
Sbjct: 1321 QELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKV 1380
Query: 558 HRSLEQYDQVLDGAHGASLTDLANLSE 584
L + L+ A L D LS+
Sbjct: 1381 DDDLGTIES-LEEAKKKLLKDAEALSQ 1406
Score = 52.8 bits (125), Expect = 1e-06
Identities = 59/273 (21%), Positives = 117/273 (42%), Gaps = 43/273 (15%)
Query: 388 DISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDL-------DRETSSLQELEA 440
++S I QL+ EK SL++ E+EEA + +V LQ+ L D + +++ LE
Sbjct: 1333 NLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEE 1392
Query: 441 QKQDA---QDRLDEMDQQKAKLRDMLSDVRQKCQDE-----------TQMISSLK----- 481
K+ + L + ++KA D L + + Q E Q+ S+L+
Sbjct: 1393 AKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKK 1452
Query: 482 -TQIQSQESDLKSQ-EDDLNRAKSE----------LNRLQQEETQLEQSIQAGRVQLETI 529
Q+ ++E + ++ ++ +RA++E L R +E + ++ + QL
Sbjct: 1453 FDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRAD 1512
Query: 530 IKSLKSTQDEINQARSKLSQ----LHESRQEAHRSLEQYDQVLDGAHGASLTDLANLSEG 585
++ L S++D++ + +L + L + +E LE+ + L A L N+
Sbjct: 1513 MEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAM 1572
Query: 586 VSLAERGSFGAMDDPFKNKALLFSNNTQELHPD 618
+ ER D+ + K L +EL +
Sbjct: 1573 KAQFER-DLQTRDEQNEEKKRLLIKQVRELEAE 1604
Score = 52.4 bits (124), Expect = 2e-06
Identities = 43/206 (20%), Positives = 93/206 (45%), Gaps = 6/206 (2%)
Query: 370 DSSGSLGSGEFTGVKELDDISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLD 429
D + SG+ + E + IAQL+ E + ++ + R+ T +V L +L
Sbjct: 1715 DEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELA 1774
Query: 430 RETSSLQELEAQKQDAQDRLDEMDQQKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQES 489
E S+ Q+ + +Q + + E+ KAKL+++ V+ K + IS+L+ +I E
Sbjct: 1775 AERSAAQKSDNARQQLERQNKEL---KAKLQELEGAVKSKFK---ATISALEAKIGQLEE 1828
Query: 490 DLKSQEDDLNRAKSELNRLQQEETQLEQSIQAGRVQLETIIKSLKSTQDEINQARSKLSQ 549
L+ + + A + R +++ ++ ++ R + + ++ + Q + +L +
Sbjct: 1829 QLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEE 1888
Query: 550 LHESRQEAHRSLEQYDQVLDGAHGAS 575
E A+ S + + LD A A+
Sbjct: 1889 AEEEATRANASRRKLQRELDDATEAN 1914
Score = 50.4 bits (119), Expect = 7e-06
Identities = 42/203 (20%), Positives = 89/203 (43%), Gaps = 18/203 (8%)
Query: 384 KELDDISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRE----TSSLQELE 439
K+LD QE+ E L ++ EK ++ + V L + +++ LE
Sbjct: 1255 KKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLE 1314
Query: 440 AQKQDAQDRLDEMDQQKAKLRDML-------SDVRQKCQDETQMISSLKTQI---QSQES 489
+Q QD Q+ L E +QK L + + ++++ ++E + +L+ Q+ QSQ +
Sbjct: 1315 SQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLA 1374
Query: 490 DLKSQEDD----LNRAKSELNRLQQEETQLEQSIQAGRVQLETIIKSLKSTQDEINQARS 545
D K + DD + + +L ++ L Q ++ + + + K+ Q E++
Sbjct: 1375 DTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTV 1434
Query: 546 KLSQLHESRQEAHRSLEQYDQVL 568
L + + +++DQ+L
Sbjct: 1435 DLDHQRQVASNLEKKQKKFDQLL 1457
Score = 50.1 bits (118), Expect = 9e-06
Identities = 41/201 (20%), Positives = 94/201 (46%), Gaps = 19/201 (9%)
Query: 383 VKELDDISQEIAQ-------LQREKYSLEQDIREKEEAI---RQKTSEVQELQNDLDRET 432
+K+ + +SQ + + L++ K L+Q++ + + RQ S +++ Q D+
Sbjct: 1398 LKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLL 1457
Query: 433 SSLQELEAQKQDAQDRLDEMDQQKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLK 492
+ + + A+ + +DR + ++K L+ ++ + + Q+++ DL
Sbjct: 1458 AEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLM 1517
Query: 493 SQEDDLNRAKSELNRLQQEETQLEQSIQAGRVQLETIIKSLKSTQD-----EINQARSKL 547
S +DD+ + ++ L++ + LEQ ++ R QLE + L++T+D E+N K
Sbjct: 1518 SSKDDVGK---NVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMK- 1573
Query: 548 SQLHESRQEAHRSLEQYDQVL 568
+Q Q E+ ++L
Sbjct: 1574 AQFERDLQTRDEQNEEKKRLL 1594
Score = 48.9 bits (115), Expect = 2e-05
Identities = 46/198 (23%), Positives = 91/198 (45%), Gaps = 26/198 (13%)
Query: 375 LGSGEFTGVKELDDISQEIAQLQREKYSLEQDIREK---EEAIRQKTSEVQELQNDLDRE 431
L E G+K D + +QLQ + L+++ R+K IRQ L+ E
Sbjct: 1296 LEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQ-----------LEEE 1344
Query: 432 TSSLQELEAQKQDAQDRLDEMDQQKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDL 491
+SLQE + ++++A+ L ++Q L+ L+D ++K D+ I SL+ + D
Sbjct: 1345 KNSLQEQQEEEEEARKNL---EKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDA 1401
Query: 492 KSQEDDLNRAKSELNRLQQEETQLEQSIQAGRVQLE---TIIKSLKSTQDEINQARSKLS 548
++ L ++L++ + +L+Q + V L+ + +L+ Q + +Q
Sbjct: 1402 EALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQL----- 1456
Query: 549 QLHESRQEAHRSLEQYDQ 566
L E + + R E+ D+
Sbjct: 1457 -LAEEKSISARYAEERDR 1473
Score = 47.0 bits (110), Expect = 8e-05
Identities = 45/225 (20%), Positives = 91/225 (40%), Gaps = 22/225 (9%)
Query: 384 KELDDISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEAQKQ 443
K+L + EI QLQ E + E A R E EL +++ S L +K+
Sbjct: 1680 KKLKSLEAEILQLQEE-------LASSERARRHAEQERDELADEITNSASGKSALLDEKR 1732
Query: 444 DAQDRLDEMDQQKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLKSQED---DLNR 500
+ R+ +++++ + + + + + + T + +L ++ ++ S + ++ L R
Sbjct: 1733 RLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLER 1792
Query: 501 AKSELN-RLQQEE-----------TQLEQSIQAGRVQLETIIKSLKSTQDEINQARSKLS 548
EL +LQ+ E + LE I QLE K + + + KL
Sbjct: 1793 QNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLK 1852
Query: 549 QLHESRQEAHRSLEQYDQVLDGAHGASLTDLANLSEGVSLAERGS 593
++ ++ R +QY + ++ A+ L E A R +
Sbjct: 1853 EIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRAN 1897
Score = 45.8 bits (107), Expect = 2e-04
Identities = 42/194 (21%), Positives = 98/194 (50%), Gaps = 32/194 (16%)
Query: 380 FTGVKELDDISQEIAQLQREKYSLEQDIREKEE---AIRQKTSEVQELQNDLDRETSSL- 435
FT VK L ++++ E++++ K+E +++K ++V+ +++R+ L
Sbjct: 838 FTKVKPLLQVTRQ-----------EEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLL 886
Query: 436 -------QELEAQKQ---DAQDRLDEMDQQKAKLRDMLSDVRQKCQDE---TQMISSLKT 482
++L+A+ + +A++ + +K +L ++L D+ + ++E Q++ + K
Sbjct: 887 EEKNILAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKK 946
Query: 483 QIQSQESDLKSQ--EDDLNRAKSELNRLQQEE--TQLEQSIQAGRVQLETIIKSLKSTQD 538
++Q+ DL+ Q E++ R K +L ++ E ++E+ I Q IK K +D
Sbjct: 947 KMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMED 1006
Query: 539 EINQARSKLSQLHE 552
I + S+L++ E
Sbjct: 1007 RIAECSSQLAEEEE 1020
Score = 45.8 bits (107), Expect = 2e-04
Identities = 38/159 (23%), Positives = 78/159 (49%), Gaps = 14/159 (8%)
Query: 394 AQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEAQKQDAQDRLDEMD 453
A+L +K LE+ + + E + ++ Q LQN+ ++++A QD +++LDE +
Sbjct: 911 ARLAAKKQELEEILHDLESRVEEEEERNQILQNEK-------KKMQAHIQDLEEQLDEEE 963
Query: 454 --QQKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLKSQEDDLNRAKSELNRLQQE 511
+QK +L + ++ + K +E ++ L+ Q + K ED + S+L +++
Sbjct: 964 GARQKLQLEKVTAEAKIKKMEEEILL--LEDQNSKFIKEKKLMEDRIAECSSQLAEEEEK 1021
Query: 512 ETQLEQSIQAGRV---QLETIIKSLKSTQDEINQARSKL 547
L + V LE +K + T+ E+ +A+ KL
Sbjct: 1022 AKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKL 1060
Score = 45.1 bits (105), Expect = 3e-04
Identities = 43/181 (23%), Positives = 86/181 (47%), Gaps = 14/181 (7%)
Query: 384 KELDDISQEIAQLQREKY-----SLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQEL 438
KEL QE+ + K+ +LE I + EE + Q+ E + R L+E+
Sbjct: 1795 KELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEI 1854
Query: 439 EAQKQDAQDRLDE----MDQQKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLKSQ 494
Q +D + D+ M++ A+++ + + ++ ++E ++ + ++Q + D
Sbjct: 1855 FMQVEDERRHADQYKEQMEKANARMKQLKRQL-EEAEEEATRANASRRKLQRELDDATEA 1913
Query: 495 EDDLNRAKSEL-NRLQQEETQLEQSIQAGRVQLETIIKSLKSTQDEINQARSKLSQLHES 553
+ L+R S L NRL++ S ++GR QL SL+ + D+ SK S ++E+
Sbjct: 1914 NEGLSREVSTLKNRLRRGGPISFSSSRSGRRQLHLEGASLELSDDD---TESKTSDVNET 1970
Query: 554 R 554
+
Sbjct: 1971 Q 1971
Score = 42.4 bits (98), Expect = 0.002
Identities = 36/196 (18%), Positives = 86/196 (43%), Gaps = 21/196 (10%)
Query: 385 ELDDISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEAQKQD 444
EL+D ++ A K +E D+++ E ++++ D L++L+AQ +D
Sbjct: 1604 ELEDERKQRALAVASKKKMEIDLKDLE-------AQIEAANKARDEVIKQLRKLQAQMKD 1656
Query: 445 AQDRLDEMDQQKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLKSQE-------DD 497
Q L+E + ++ + +K + I L+ ++ S E + E D+
Sbjct: 1657 YQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADE 1716
Query: 498 LNRAKS-------ELNRLQQEETQLEQSIQAGRVQLETIIKSLKSTQDEINQARSKLSQL 550
+ + S E RL+ QLE+ ++ + +E + + T +++ ++L+
Sbjct: 1717 ITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAE 1776
Query: 551 HESRQEAHRSLEQYDQ 566
+ Q++ + +Q ++
Sbjct: 1777 RSAAQKSDNARQQLER 1792
Score = 41.2 bits (95), Expect = 0.004
Identities = 51/236 (21%), Positives = 105/236 (44%), Gaps = 25/236 (10%)
Query: 383 VKELDDISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEAQK 442
+K + ++ +IA+LQ E + E+ R K E +QK +E L+ L+ +
Sbjct: 1110 LKVVRELQAQIAELQ-EDFESEKASRNKAE--KQKRDLSEE-----------LEALKTEL 1155
Query: 443 QDAQDRLDEMDQQKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLKSQEDDLNRAK 502
+D D + + K ++++++ ++ET+ + + QIQ + ++L+
Sbjct: 1156 EDTLDTTAAQQELRTKREQEVAELKKALEEETK---NHEAQIQDMRQRHATALEELSEQL 1212
Query: 503 SELNRLQQEETQLEQSIQAGRVQLETIIKSLKSTQDEINQARSKLSQLHESRQEAHRSLE 562
+ R + + +Q ++ +L +K L+ + E R KL QE H +
Sbjct: 1213 EQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLD---AQVQELHAKVS 1269
Query: 563 QYDQV-LDGAHGAS--LTDLANLSEGVSLAERGSFGAMDDPFKNKALLFSNNTQEL 615
+ D++ ++ A AS +L N+S + AE+ D ++ L +TQEL
Sbjct: 1270 EGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQL--QDTQEL 1323
Score = 38.9 bits (89), Expect = 0.021
Identities = 29/158 (18%), Positives = 66/158 (41%)
Query: 389 ISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEAQKQDAQDR 448
+ E ++Q LE+ + E+E A ++ E + + + + LE Q
Sbjct: 941 LQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKE 1000
Query: 449 LDEMDQQKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLKSQEDDLNRAKSELNRL 508
M+ + A+ L++ +K ++ ++ + + I E LK +E + +L
Sbjct: 1001 KKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKL 1060
Query: 509 QQEETQLEQSIQAGRVQLETIIKSLKSTQDEINQARSK 546
E T L+ I + Q++ + L ++E+ A ++
Sbjct: 1061 DGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALAR 1098
Score = 35.0 bits (79), Expect = 0.30
Identities = 28/129 (21%), Positives = 63/129 (48%), Gaps = 15/129 (11%)
Query: 458 KLRDMLSDVRQKCQ-----DETQMISSLKTQIQSQESDLKSQEDDLNRAKSELNRLQQEE 512
K++ +L RQ+ + +E + +T+++ + +++ + L K+ L Q E
Sbjct: 840 KVKPLLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAE 899
Query: 513 TQL-------EQSIQAGRVQLETIIKSLKSTQDEINQARSKLSQLHESRQEAHRSLEQYD 565
T+L + A + +LE I+ L+S +E + R+++ Q + + +AH ++ +
Sbjct: 900 TELFAEAEEMRARLAAKKQELEEILHDLESRVEE-EEERNQILQNEKKKMQAH--IQDLE 956
Query: 566 QVLDGAHGA 574
+ LD GA
Sbjct: 957 EQLDEEEGA 965
>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
sapiens]
Length = 1940
Score = 68.9 bits (167), Expect = 2e-11
Identities = 53/214 (24%), Positives = 109/214 (50%), Gaps = 22/214 (10%)
Query: 384 KELDDISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEAQKQ 443
K++DD+ +A++++EK++ E ++ + ++ S + E L RE +LQE Q
Sbjct: 953 KDIDDLELTLAKVEKEKHATENKVKN----LTEELSGLDETIAKLTREKKALQEAHQQAL 1008
Query: 444 D----AQDRLDEMDQQKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLKSQED--- 496
D +D+++ +++ K+KL + D+ + E ++ L+ + E DLK ++
Sbjct: 1009 DDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESIL 1068
Query: 497 DLNRAKSELN-RLQQ---EETQLEQSI---QAGRVQLETIIKSLKS----TQDEINQARS 545
DL K +L+ RL++ E QL+ + Q +Q + IK L++ ++EI R+
Sbjct: 1069 DLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERA 1128
Query: 546 KLSQLHESRQEAHRSLEQYDQVLDGAHGASLTDL 579
++ + R + R LE+ + L+ A G + T +
Sbjct: 1129 TRAKTEKQRSDYARELEELSERLEEAGGVTSTQI 1162
Score = 58.2 bits (139), Expect = 3e-08
Identities = 49/203 (24%), Positives = 101/203 (49%), Gaps = 23/203 (11%)
Query: 385 ELDDISQEIAQLQREKYSLEQDIREKEEAI---RQKTSEVQELQNDLDRETSSLQ----E 437
E+DD+S + + + K +LE+ R E+ + R K E+Q ++L + S LQ E
Sbjct: 1228 EIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGE 1287
Query: 438 LEAQKQDAQDRLDEMDQQKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQESD---LKSQ 494
L Q ++ + + ++ + K +++++ ++E + ++L +QS D L+ Q
Sbjct: 1288 LSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQ 1347
Query: 495 EDDLNRAKSELNRLQQEETQLEQSIQAGRVQLETIIKSLKSTQDEINQARSKLSQ-LHES 553
++ K+E LQ+ ++ + R + ET +++ T +E+ +A+ KL+Q L +S
Sbjct: 1348 YEEEQEGKAE---LQRALSKANSEVAQWRTKYET--DAIQRT-EELEEAKKKLAQRLQDS 1401
Query: 554 RQEAH------RSLEQYDQVLDG 570
++ SLE+ Q L G
Sbjct: 1402 EEQVEAVNAKCASLEKTKQRLQG 1424
Score = 56.6 bits (135), Expect = 1e-07
Identities = 45/201 (22%), Positives = 96/201 (47%), Gaps = 28/201 (13%)
Query: 384 KELDDISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEAQKQ 443
KE+ + +E + + E E +E EE + E +LQ + E+ +L
Sbjct: 848 KEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLL------- 900
Query: 444 DAQDRLDEMDQQKAKLRDMLSDVRQKCQDETQM---ISSLKTQIQSQESDLKSQEDDL-- 498
DA++R D++ + K +L + +V ++ +DE ++ +++ K +++ + S+LK DDL
Sbjct: 901 DAEERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLEL 960
Query: 499 -------------NRAKS---ELNRLQQEETQLEQSIQAGRVQLETIIKSLKSTQDEINQ 542
N+ K+ EL+ L + +L + +A + + + L++ +D++N
Sbjct: 961 TLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNS 1020
Query: 543 ARSKLSQLHESRQEAHRSLEQ 563
S+L + ++ SLEQ
Sbjct: 1021 LNKTKSKLEQQVEDLESSLEQ 1041
Score = 53.9 bits (128), Expect = 6e-07
Identities = 52/208 (25%), Positives = 94/208 (45%), Gaps = 25/208 (12%)
Query: 386 LDDISQE---IAQLQREKYSLEQDIREKEEAIRQKTS-------EVQELQNDLDRETSSL 435
LDD+ E + L + K LEQ + + E ++ Q+ ++L+ DL S+
Sbjct: 1008 LDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESI 1067
Query: 436 QELEAQKQDAQDRLDEMDQQKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLKSQE 495
+LE KQ +RL + D + +L+ + D + + I L+ +I+ E +++++
Sbjct: 1068 LDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAER 1127
Query: 496 DDLNRAKSELNR---LQQEETQLEQSIQAGRVQLETIIKSLKSTQDEINQAR-SKLSQLH 551
RAK+E R ++ E E+ +AG V STQ E+N+ R ++ +L
Sbjct: 1128 --ATRAKTEKQRSDYARELEELSERLEEAGGV---------TSTQIELNKKREAEFLKLR 1176
Query: 552 ESRQEAHRSLEQYDQVLDGAHGASLTDL 579
+EA E L H S+ +L
Sbjct: 1177 RDLEEATLQHEAMVAALRKKHADSVAEL 1204
Score = 52.8 bits (125), Expect = 1e-06
Identities = 40/196 (20%), Positives = 91/196 (46%), Gaps = 21/196 (10%)
Query: 384 KELDDISQEIAQLQREKYSLEQDIR------EKEEAI--------RQKTSEVQELQNDLD 429
+ L D + QL + K+ LE I+ E EE I R+ E EL+ D+D
Sbjct: 897 ENLLDAEERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDID 956
Query: 430 RETSSLQELEAQKQDAQDRLDEMDQQKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQES 489
+L ++E +K ++++ + ++ + L + ++ + T+ +L+ Q
Sbjct: 957 DLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKL-------TREKKALQEAHQQALD 1009
Query: 490 DLKSQEDDLNRAKSELNRLQQEETQLEQSIQAGRVQLETIIKSLKSTQDEINQARSKLSQ 549
DL+++ED +N ++L+Q+ LE S++ + + ++ + + ++ A+ +
Sbjct: 1010 DLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILD 1069
Query: 550 LHESRQEAHRSLEQYD 565
L +Q+ L++ D
Sbjct: 1070 LENDKQQLDERLKKKD 1085
Score = 52.4 bits (124), Expect = 2e-06
Identities = 46/201 (22%), Positives = 94/201 (46%), Gaps = 32/201 (15%)
Query: 388 DISQEIAQLQREKYSLEQ----------DIREKEEAIRQKTSEVQELQNDLDRETSSLQE 437
++ ++I LQR K LE+ D+ E++ + + ++++ L+ + L E
Sbjct: 1203 ELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQ---LSE 1259
Query: 438 LEAQKQDAQDRLDEMDQQKAKLRDMLSDVRQKCQDETQMISSLKTQIQS---QESDLKSQ 494
+ ++ Q L E+ QK++L+ ++ ++ +++ ++S L Q+ Q +LK Q
Sbjct: 1260 ARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQ 1319
Query: 495 EDDLNRAKSELNRLQQE--------ETQLEQSIQAGRVQLETIIKSLKSTQDEINQARSK 546
++ N+AK+ L Q Q E+ Q G+ +L+ ++L E+ Q R+K
Sbjct: 1320 LEEENKAKNALAHALQSSRHDCDLLREQYEEE-QEGKAELQ---RALSKANSEVAQWRTK 1375
Query: 547 LS----QLHESRQEAHRSLEQ 563
Q E +EA + L Q
Sbjct: 1376 YETDAIQRTEELEEAKKKLAQ 1396
Score = 51.6 bits (122), Expect = 3e-06
Identities = 56/263 (21%), Positives = 114/263 (43%), Gaps = 29/263 (11%)
Query: 372 SGSLGSGEFTGVKELDDISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRE 431
S SL + F ++ ++ ++RE +LEQ+I + E I + + EL+
Sbjct: 1475 SRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELE------ 1528
Query: 432 TSSLQELEAQKQDAQDRLDE----MDQQKAK-------LRDMLSDVRQKCQDETQMISSL 480
S +++E +K D Q L+E ++ ++AK L + S++ +K ++ + I L
Sbjct: 1529 -KSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQL 1587
Query: 481 KTQIQSQESDLKSQEDDLNRAKSELNRLQQ----EETQLEQSIQAGRVQLETIIKSLKST 536
K Q ++S D R+++E RL++ + ++E + Q +K L+S
Sbjct: 1588 KRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSV 1647
Query: 537 QDEINQARSKLSQLHESRQEAHRSL---EQYDQVLDGAHGASLTDLANLSEGVSLAERGS 593
Q ++ + L +++ L E+ +L A + +L E A + +
Sbjct: 1648 QGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQ----AEVEELRATLEQTERARKLA 1703
Query: 594 FGAMDDPFKNKALLFSNNTQELH 616
+ D + LL + NT +H
Sbjct: 1704 EQELLDSNERVQLLHTQNTSLIH 1726
Score = 49.7 bits (117), Expect = 1e-05
Identities = 35/201 (17%), Positives = 96/201 (47%), Gaps = 8/201 (3%)
Query: 388 DISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEAQKQDAQD 447
++ +++ L +EK L+ ++ + E + +L + + ++E+ + +D ++
Sbjct: 873 ELEEKLVTLVQEKNDLQLQVQAESENLLDAEERCDQLIKAKFQLEAKIKEVTERAEDEEE 932
Query: 448 RLDEMDQQKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLKSQEDDLNRAKSELNR 507
E+ +K KL D S++++ D ++ ++ + + E+ +K+ ++L+ + +
Sbjct: 933 INAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAK 992
Query: 508 LQQEETQLEQS-------IQAGRVQLETIIKSLKSTQDEINQARSKLSQLHESRQEAHRS 560
L +E+ L+++ +QA ++ ++ K+ + ++ S L Q + R + R+
Sbjct: 993 LTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERN 1052
Query: 561 LEQYDQVLDGAHGASLTDLAN 581
+ + L A S+ DL N
Sbjct: 1053 KRKLEGDLKLAQ-ESILDLEN 1072
Score = 47.4 bits (111), Expect = 6e-05
Identities = 40/193 (20%), Positives = 88/193 (45%), Gaps = 15/193 (7%)
Query: 384 KELDDISQEIAQLQREKYSLEQDIREKEEAIRQK-------TSEVQELQNDLDRETSSLQ 436
+ L +++ + ++LQ E L + + EKE + Q T + +EL+ L+ E +
Sbjct: 1269 RSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKN 1328
Query: 437 ELEAQKQDAQDRLDEMDQQKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLKSQED 496
L Q ++ D + +Q + ++ +++++ ++ +T+ E+D + +
Sbjct: 1329 ALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTK---YETDAIQRTE 1385
Query: 497 DLNRAKSEL-NRLQQEETQLEQSIQAGRVQLETIIKSLKSTQDEINQARSKLSQLHESRQ 555
+L AK +L RLQ E Q+E ++ A LE K+ + Q E+ + + +
Sbjct: 1386 ELEEAKKKLAQRLQDSEEQVE-AVNAKCASLE---KTKQRLQGEVEDLMVDVERANSLAA 1441
Query: 556 EAHRSLEQYDQVL 568
+ +D+VL
Sbjct: 1442 ALDKKQRNFDKVL 1454
Score = 45.1 bits (105), Expect = 3e-04
Identities = 47/210 (22%), Positives = 89/210 (42%), Gaps = 36/210 (17%)
Query: 389 ISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEAQKQ----- 443
+ ++ QLQ E +D R EE ++ ++ + +L +E + LE K+
Sbjct: 1731 LETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQT 1790
Query: 444 --DAQDRLDEMDQQKAK------------LRDMLSDVRQKCQDETQMISSL-KTQIQSQE 488
D Q RLDE +Q K +R++ ++ + + T+ + L K + + +E
Sbjct: 1791 VKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEFELEGEQKKNTESVKGLRKYERRVKE 1850
Query: 489 SDLKSQEDDLN--RAKSELNRLQ--------QEETQLEQS------IQAGRVQLETIIKS 532
+S+ED N R + +++LQ Q E EQ+ + + +LE +
Sbjct: 1851 LTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEADEQANAHLTKFRKAQHELEEAEER 1910
Query: 533 LKSTQDEINQARSKLSQLHESRQEAHRSLE 562
+ ++N+ R+K SR H S E
Sbjct: 1911 ADIAESQVNKLRAKTRDFTSSRMVVHESEE 1940
Score = 44.7 bits (104), Expect = 4e-04
Identities = 42/224 (18%), Positives = 99/224 (44%), Gaps = 18/224 (8%)
Query: 385 ELDDISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEAQKQD 444
E++++ + Q +R + EQ++ + E ++ ++ L + + + L +L+++ +D
Sbjct: 1685 EVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVED 1744
Query: 445 A-QDRLDEMDQQKAKLRD--MLSDVRQKCQDETQMISSLKTQIQSQESDLKSQEDD---- 497
A +D + ++ K + D M+++ +K QD + + +K ++ DL+ + D+
Sbjct: 1745 ASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQL 1804
Query: 498 -LNRAKSELNRLQQEETQLEQSIQA----------GRVQLETIIKSLKSTQDEINQARSK 546
L K ++ +L+ +LE ++ G + E +K L +E + +
Sbjct: 1805 ALKGGKKQIQKLETRIRELEFELEGEQKKNTESVKGLRKYERRVKELTYQSEEDRKNVLR 1864
Query: 547 LSQLHESRQEAHRSLEQYDQVLDGAHGASLTDLANLSEGVSLAE 590
L L + Q +S ++ + D A LT + AE
Sbjct: 1865 LQDLVDKLQVKVKSYKRQAEEADEQANAHLTKFRKAQHELEEAE 1908
Score = 43.5 bits (101), Expect = 8e-04
Identities = 36/171 (21%), Positives = 85/171 (49%), Gaps = 19/171 (11%)
Query: 420 EVQELQNDLDRETSSLQELEAQKQDAQDRLDEMDQQKAKLR-------DMLSDVRQKCQD 472
E+ ++ + + L + EA++++ +++L + Q+K L+ + L D ++C
Sbjct: 849 EMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEERCD- 907
Query: 473 ETQMISSLKTQIQSQESDLKSQEDDLNRAKSEL----NRLQQEETQLEQSIQAGRVQLET 528
Q+I + K Q++++ ++ + +D +EL +L+ E ++L++ I + L
Sbjct: 908 --QLIKA-KFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAK 964
Query: 529 IIKSLKSTQDEINQARSKLSQLHESRQEAHRSLEQYDQVLDGAHGASLTDL 579
+ K +T++++ +LS L E+ + L + + L AH +L DL
Sbjct: 965 VEKEKHATENKVKNLTEELSGLDETIAK----LTREKKALQEAHQQALDDL 1011
Score = 43.1 bits (100), Expect = 0.001
Identities = 49/223 (21%), Positives = 97/223 (43%), Gaps = 52/223 (23%)
Query: 391 QEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQE-LEAQKQDAQDRL 449
++I +LQ LE++I E E A R KT ++ ++D RE L E LE ++
Sbjct: 1107 KKIKELQARIEELEEEI-EAERATRAKT---EKQRSDYARELEELSERLEEAGGVTSTQI 1162
Query: 450 DEMDQQKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLKSQEDDLNRAKSELNRLQ 509
+ +++A+ + D+ + M+++L+ + ++L Q D+L R K +L + +
Sbjct: 1163 ELNKKREAEFLKLRRDLEEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEK-E 1221
Query: 510 QEETQLE--------QSIQAGRVQLETIIKSLKSTQDEINQARSK--------------- 546
+ E +LE +S+ + LE I ++L +D++++AR K
Sbjct: 1222 KSEFKLEIDDLSSSMESVSKSKANLEKICRTL---EDQLSEARGKNEEIQRSLSELTTQK 1278
Query: 547 --------------------LSQLHESRQEAHRSLEQYDQVLD 569
+SQL S+Q + E+ + L+
Sbjct: 1279 SRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLE 1321
Score = 42.4 bits (98), Expect = 0.002
Identities = 42/205 (20%), Positives = 94/205 (45%), Gaps = 23/205 (11%)
Query: 384 KELDDISQEIAQLQRE--------KYSLEQDIREKEEAIRQKT------SEVQELQNDLD 429
+++ + +EI QL+R + +L+ ++R + EAIR K +E++ + +
Sbjct: 1575 RKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHAN 1634
Query: 430 RETSS----LQELEAQKQDAQDRLDEMDQQKAKLRDMLSDVRQKCQDETQMISSLKTQIQ 485
R+ + L+ ++ Q +D Q LD+ + + L++ L+ V ++ + L+ ++
Sbjct: 1635 RQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLE 1694
Query: 486 SQESDLKSQEDDLNRAKSELNRLQQEETQLEQSIQAGRVQLETIIKSLKS-TQDEINQAR 544
E K E +L + + L + T L + + +LET + L+S +D AR
Sbjct: 1695 QTERARKLAEQELLDSNERVQLLHTQNTSLIHT----KKKLETDLMQLQSEVEDASRDAR 1750
Query: 545 SKLSQLHESRQEAHRSLEQYDQVLD 569
+ + ++ +A E+ + D
Sbjct: 1751 NAEEKAKKAITDAAMMAEELKKEQD 1775
Score = 39.7 bits (91), Expect = 0.012
Identities = 37/199 (18%), Positives = 86/199 (43%), Gaps = 23/199 (11%)
Query: 390 SQEIAQLQREKYSLEQDIR-EKEEAIRQKTSEV---------------QELQNDLDRETS 433
S+ L RE+Y EQ+ + E + A+ + SEV +EL+ +
Sbjct: 1337 SRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQ 1396
Query: 434 SLQELEAQKQDAQDRLDEMDQQKAKLRDMLSDVRQKCQDETQMISSLKTQ-------IQS 486
LQ+ E Q + + +++ K +L+ + D+ + + ++L + +
Sbjct: 1397 RLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAE 1456
Query: 487 QESDLKSQEDDLNRAKSELNRLQQEETQLEQSIQAGRVQLETIIKSLKSTQDEINQARSK 546
++ + + +L + E L E +L+ + + QLET+ + K+ + EI +
Sbjct: 1457 WKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQ 1516
Query: 547 LSQLHESRQEAHRSLEQYD 565
+++ ++ E +S +Q +
Sbjct: 1517 IAENGKTIHELEKSRKQIE 1535
Score = 37.4 bits (85), Expect = 0.060
Identities = 27/181 (14%), Positives = 74/181 (40%), Gaps = 1/181 (0%)
Query: 387 DDISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEAQKQDAQ 446
+D+ +++A ++R L+ ++ E + Q + + +L +Q L Q
Sbjct: 1666 EDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLI 1725
Query: 447 DRLDEMDQQKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLKSQEDDLNRAKSELN 506
+++ +L+ + D + ++ + T +LK ++D +
Sbjct: 1726 HTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKK 1785
Query: 507 RLQQEETQLEQSI-QAGRVQLETIIKSLKSTQDEINQARSKLSQLHESRQEAHRSLEQYD 565
L+Q L+ + +A ++ L+ K ++ + I + +L + E+ + L +Y+
Sbjct: 1786 NLEQTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEFELEGEQKKNTESVKGLRKYE 1845
Query: 566 Q 566
+
Sbjct: 1846 R 1846
>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
sapiens]
Length = 1937
Score = 68.6 bits (166), Expect = 2e-11
Identities = 50/210 (23%), Positives = 107/210 (50%), Gaps = 22/210 (10%)
Query: 384 KELDDISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEAQKQ 443
K++DD+ +A++++EK++ E ++ + ++ + + E L +E +LQE Q
Sbjct: 955 KDIDDLELTLAKVEKEKHATENKVKN----LTEEMAGLDETIAKLSKEKKALQETHQQTL 1010
Query: 444 D----AQDRLDEMDQQKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLKSQED--- 496
D +D+++ + + K KL + D+ + E ++ L+ + E DLK ++
Sbjct: 1011 DDLQAEEDKVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTM 1070
Query: 497 DLNRAKSELN-RLQQEETQLEQSI------QAGRVQLETIIKSLKS----TQDEINQARS 545
D+ K +L+ +L+++E ++ I QA +QL+ IK L++ +EI R+
Sbjct: 1071 DMENDKQQLDEKLEKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERA 1130
Query: 546 KLSQLHESRQEAHRSLEQYDQVLDGAHGAS 575
++ + R + R LE+ + L+ A GA+
Sbjct: 1131 SRAKAEKQRSDLSRELEEISERLEEAGGAT 1160
Score = 53.9 bits (128), Expect = 6e-07
Identities = 43/182 (23%), Positives = 88/182 (48%), Gaps = 16/182 (8%)
Query: 385 ELDDISQEIAQLQREKYSLEQDIREKEEAIRQ---KTSEVQELQNDLDRETSSLQ----E 437
E DD+S + + K +LE+ R E+ + + K E Q L NDL + + LQ E
Sbjct: 1230 ETDDLSSNAEAISKAKGNLEKMCRSLEDQVSELKTKEEEQQRLINDLTAQRARLQTEAGE 1289
Query: 438 LEAQKQDAQDRLDEMDQQKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQESD---LKSQ 494
Q + + ++ + K + +++ + ++ET+ ++L +QS D L+ Q
Sbjct: 1290 YSRQLDEKDALVSQLSRSKQASTQQIEELKHQLEEETKAKNALAHALQSSRHDCDLLREQ 1349
Query: 495 EDDLNRAKSELNRLQQEETQLEQSIQAGRVQLETIIKSLKSTQDEINQARSKLSQLHESR 554
++ K+E LQ+ ++ + R + ET +++ T +E+ +A+ KL+Q +
Sbjct: 1350 YEEEQEGKAE---LQRALSKANSEVAQWRTKYET--DAIQRT-EELEEAKKKLAQRLQEA 1403
Query: 555 QE 556
+E
Sbjct: 1404 EE 1405
Score = 51.2 bits (121), Expect = 4e-06
Identities = 41/190 (21%), Positives = 85/190 (44%), Gaps = 7/190 (3%)
Query: 384 KELDDISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRET----SSLQELE 439
K+ D+S+E+ ++ + E +++ +E Q+L+ DL+ T + + L
Sbjct: 1137 KQRSDLSRELEEISERLEEAGGATSAQVELNKKREAEFQKLRRDLEEATLQHEAMVAALR 1196
Query: 440 AQKQDAQDRLDEMDQQKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLKSQEDDLN 499
+ D+ L E +++ L + + + ET +SS I + +L+ L
Sbjct: 1197 KKHADSMAELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAKGNLEKMCRSLE 1256
Query: 500 RAKSELNRLQQEETQLEQSIQAGRVQLETIIKSLKSTQDEINQARSKLSQLHESRQEAHR 559
SEL ++E+ +L + A R +L+T DE + + +SQL S+Q + +
Sbjct: 1257 DQVSELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKD---ALVSQLSRSKQASTQ 1313
Query: 560 SLEQYDQVLD 569
+E+ L+
Sbjct: 1314 QIEELKHQLE 1323
Score = 50.4 bits (119), Expect = 7e-06
Identities = 37/200 (18%), Positives = 97/200 (48%), Gaps = 21/200 (10%)
Query: 384 KELDDISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEAQKQ 443
KE+ + +E + + E E +E EE + E +LQ + E SL
Sbjct: 850 KEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSLA------- 902
Query: 444 DAQDRLDEMDQQKAKLRDMLSDVRQKCQDETQM---ISSLKTQIQSQESDLKSQEDDL-- 498
DA++R +++ + K +L + +V ++ ++E ++ +++ K +++ + S+LK DDL
Sbjct: 903 DAEERCEQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDLEL 962
Query: 499 ---------NRAKSELNRLQQEETQLEQSIQAGRVQLETIIKSLKSTQDEINQARSKLSQ 549
+ ++++ L +E L+++I + + + ++ + T D++ K++
Sbjct: 963 TLAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDDLQAEEDKVNI 1022
Query: 550 LHESRQEAHRSLEQYDQVLD 569
L +++ + + ++ + L+
Sbjct: 1023 LTKAKTKLEQQVDDLEGSLE 1042
Score = 49.7 bits (117), Expect = 1e-05
Identities = 44/208 (21%), Positives = 88/208 (42%), Gaps = 27/208 (12%)
Query: 388 DISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEAQKQDAQD 447
D Q +L+ K L Q ++E EE + ++ L+ R + +++L + +
Sbjct: 1381 DAIQRTEELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSNA 1440
Query: 448 RLDEMDQQKAKLRDMLSDVRQKCQDETQM--------ISSLKTQIQSQESDLKSQEDDLN 499
+D+++ +LS+ +QK +ETQ SL T++ ++ + D L
Sbjct: 1441 ACAALDKKQRNFDKVLSEWKQK-YEETQAELEASQKESRSLSTELFKVKNVYEESLDQLE 1499
Query: 500 RAKSELNRLQQEETQLEQSIQAGRVQLETIIKSLKSTQDE-------INQARSKLS---- 548
+ E LQQE + L + I G Q+ + K K + E + +A + L
Sbjct: 1500 TLRRENKNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQEKCEIQAALEEAEASLEHEEG 1559
Query: 549 -------QLHESRQEAHRSLEQYDQVLD 569
+L++ + E R + + D+ +D
Sbjct: 1560 KILRIQLELNQVKSEVDRKIAEKDEEID 1587
Score = 48.9 bits (115), Expect = 2e-05
Identities = 38/206 (18%), Positives = 96/206 (46%), Gaps = 13/206 (6%)
Query: 370 DSSGSLGSGEFTGVKELDDISQEIAQLQREKYSLEQDIREKEEAIRQ-------KTSEVQ 422
D L + E + ++D++ + A+LQ E + + EK+ + Q T +++
Sbjct: 1257 DQVSELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQASTQQIE 1316
Query: 423 ELQNDLDRETSSLQELEAQKQDAQDRLDEMDQQKAKLRDMLSDVRQKCQDETQMISSLKT 482
EL++ L+ ET + L Q ++ D + +Q + ++ +++++ ++ +T
Sbjct: 1317 ELKHQLEEETKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRT 1376
Query: 483 QIQSQESDLKSQEDDLNRAKSELNRLQQEETQLEQSIQAGRVQLETIIKSLKSTQDEINQ 542
+ E+D + ++L AK +L + QE E+ ++A + ++ K+ + Q+E+
Sbjct: 1377 K---YETDAIQRTEELEEAKKKLAQRLQE---AEEHVEAVNAKCASLEKTKQRLQNEVED 1430
Query: 543 ARSKLSQLHESRQEAHRSLEQYDQVL 568
+ + + + + +D+VL
Sbjct: 1431 LMLDVERSNAACAALDKKQRNFDKVL 1456
Score = 48.5 bits (114), Expect = 3e-05
Identities = 45/226 (19%), Positives = 109/226 (48%), Gaps = 31/226 (13%)
Query: 384 KELDDISQEIAQ-------LQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQ 436
+++DD+ + Q L+R K LE D++ +E+ ++ Q+L L+++ +
Sbjct: 1032 QQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDMENDKQQLDEKLEKKEFEIS 1091
Query: 437 ELEAQKQDAQDRLDEMDQQKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLKSQED 496
L ++ +D Q E+ QK K++++ + + ++ +E + + + + + Q SDL + +
Sbjct: 1092 NLISKIEDEQ--AVEIQLQK-KIKELQARI-EELGEEIEAERASRAKAEKQRSDLSRELE 1147
Query: 497 DLNR----------AKSELNRLQQEETQ-LEQSIQAGRVQLETIIKSL-KSTQDEINQAR 544
+++ A+ ELN+ ++ E Q L + ++ +Q E ++ +L K D + +
Sbjct: 1148 EISERLEEAGGATSAQVELNKKREAEFQKLRRDLEEATLQHEAMVAALRKKHADSMAELG 1207
Query: 545 SKLSQLHESRQEAHRSLEQYDQVLDGAHGASLTDLANLSEGVSLAE 590
++ L +Q+ + + D DL++ +E +S A+
Sbjct: 1208 EQIDNLQRVKQKLEKEKSELKMETD--------DLSSNAEAISKAK 1245
Score = 45.8 bits (107), Expect = 2e-04
Identities = 30/201 (14%), Positives = 94/201 (46%), Gaps = 8/201 (3%)
Query: 388 DISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEAQKQDAQD 447
++ +++ L +EK L+ ++ + +++ ++L + + + ++E+ + ++ ++
Sbjct: 875 ELEEKMVTLLKEKNDLQLQVQSEADSLADAEERCEQLIKNKIQLEAKIKEVTERAEEEEE 934
Query: 448 RLDEMDQQKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLKSQEDDLN-------R 500
E+ +K KL D S++++ D ++ ++ + + E+ +K+ +++ +
Sbjct: 935 INAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAK 994
Query: 501 AKSELNRLQQEETQLEQSIQAGRVQLETIIKSLKSTQDEINQARSKLSQLHESRQEAHRS 560
E LQ+ Q +QA ++ + K+ + +++ L Q + R + R+
Sbjct: 995 LSKEKKALQETHQQTLDDLQAEEDKVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERA 1054
Query: 561 LEQYDQVLDGAHGASLTDLAN 581
+ + L A +++ D+ N
Sbjct: 1055 KRKLEGDLKLAQESTM-DMEN 1074
Score = 45.1 bits (105), Expect = 3e-04
Identities = 41/202 (20%), Positives = 93/202 (46%), Gaps = 16/202 (7%)
Query: 372 SGSLGSGEFTGVKELDDISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRE 431
S SL + F ++ ++ L+RE +L+Q+I + E I + ++ EL+ +
Sbjct: 1477 SRSLSTELFKVKNVYEESLDQLETLRRENKNLQQEISDLTEQIAEGGKQIHELEKIKKQV 1536
Query: 432 TSSLQELEAQKQDAQDRLDEMDQQ----KAKLRDMLSDVRQKCQDETQMISSLK------ 481
E++A ++A+ L+ + + + +L + S+V +K ++ + I LK
Sbjct: 1537 EQEKCEIQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHTRV 1596
Query: 482 --TQIQSQESDLKSQEDDLNRAKSELNRLQQEETQLEQSIQAGRVQLETIIKSLKSTQDE 539
T + +++++S+ D L K L + E QL A R+ E+ +++ ++TQ
Sbjct: 1597 VETMQSTLDAEIRSRNDALRVKKKMEGDLNEMEIQLN---HANRLAAES-LRNYRNTQGI 1652
Query: 540 INQARSKLSQLHESRQEAHRSL 561
+ + + L +++ L
Sbjct: 1653 LKETQLHLDDALRGQEDLKEQL 1674
Score = 43.9 bits (102), Expect = 6e-04
Identities = 32/180 (17%), Positives = 82/180 (45%), Gaps = 4/180 (2%)
Query: 409 EKEEAIRQKTSEVQELQNDLDRETSSLQELEAQKQDAQDRLDEMDQQKAKLRDMLSDVRQ 468
E E+ + E Q+ +++L + + +ELE + +++ Q D L+D +
Sbjct: 847 ETEKEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSLADAEE 906
Query: 469 KCQDETQMISSLKTQIQSQESDLKSQEDDLNRAKSELNRLQQEETQLEQSIQAGRVQLET 528
+C+ + L+ +I+ + +E+ ++ +L+ E ++L++ I + L
Sbjct: 907 RCEQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDLELTLAK 966
Query: 529 IIKSLKSTQDEINQARSKLSQLHESRQEAHRSLEQYDQVLDGAHGASLTDLANLSEGVSL 588
+ K +T++++ +++ L E+ + L + + L H +L DL + V++
Sbjct: 967 VEKEKHATENKVKNLTEEMAGLDETIAK----LSKEKKALQETHQQTLDDLQAEEDKVNI 1022
Score = 40.0 bits (92), Expect = 0.009
Identities = 35/205 (17%), Positives = 91/205 (44%), Gaps = 10/205 (4%)
Query: 387 DDISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEAQKQDAQ 446
+D+ +++A ++R L+ +I E + Q + + +L + +Q L Q
Sbjct: 1668 EDLKEQLAIVERRANLLQAEIEELWATLEQTERSRKIAEQELLDASERVQLLHTQNTSLI 1727
Query: 447 DRLDEMDQQKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLKSQED---DLNRAKS 503
+ +++ ++L+ + +V Q+ ++ + T +LK ++D L R K
Sbjct: 1728 NTKKKLENDVSQLQSEVEEVIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKK 1787
Query: 504 ELNR----LQQEETQLEQ-SIQAGRVQLETIIKSLKSTQDEINQARSKLSQLHESRQEAH 558
L + LQ + EQ +++ G+ Q++ + ++ + E+ + + ++ + ++
Sbjct: 1788 NLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVENEQKRNAEAVKGLRKHE 1847
Query: 559 RSLEQ--YDQVLDGAHGASLTDLAN 581
R +++ Y D + L DL +
Sbjct: 1848 RRVKELTYQTEEDRKNVLRLQDLVD 1872
Score = 39.3 bits (90), Expect = 0.016
Identities = 31/174 (17%), Positives = 84/174 (48%), Gaps = 8/174 (4%)
Query: 394 AQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEAQKQDAQDRLDEMD 453
A L +++ + ++ + E ++ + +E++ Q + ++ L +++ +++ D+L+ +
Sbjct: 1443 AALDKKQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTELFKVKNVYEESLDQLETLR 1502
Query: 454 QQKAKLRDMLSDVRQKCQDETQMISSL---KTQIQSQESD----LKSQEDDLNRAKSELN 506
++ L+ +SD+ ++ + + I L K Q++ ++ + L+ E L + ++
Sbjct: 1503 RENKNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQEKCEIQAALEEAEASLEHEEGKIL 1562
Query: 507 RLQQEETQLEQSIQAGRVQLETIIKSLKSTQDEINQA-RSKLSQLHESRQEAHR 559
R+Q E Q++ + + + I LK + + +S L SR +A R
Sbjct: 1563 RIQLELNQVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQSTLDAEIRSRNDALR 1616
Score = 34.7 bits (78), Expect = 0.39
Identities = 51/288 (17%), Positives = 118/288 (40%), Gaps = 51/288 (17%)
Query: 282 IFLKTDLDLDGYVSGQE-VKE----IFMHSGLTQNLLAHIWA-LADTRQTGKLSKDQFAL 335
I +T L LD + GQE +KE + + L Q + +WA L T ++ K+++ +
Sbjct: 1652 ILKETQLHLDDALRGQEDLKEQLAIVERRANLLQAEIEELWATLEQTERSRKIAEQELLD 1711
Query: 336 AMYFIQ-------------QKVSKGIDPPQVLSPDMVPPSERGTPGPDSSGSLGSGEFTG 382
A +Q +K+ + Q +++ S + + +
Sbjct: 1712 ASERVQLLHTQNTSLINTKKKLENDVSQLQSEVEEVIQESRNAEEKAKKAITDAAMMAEE 1771
Query: 383 VKELDDISQEIAQLQREKYSLEQDIREK----------------------EEAIRQKTSE 420
+K+ D S A L+R K +LEQ +++ E +R+ E
Sbjct: 1772 LKKEQDTS---AHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGE 1828
Query: 421 VQ-------ELQNDLDRETSSLQELEAQKQDAQDRLDEMDQQKAKLRDMLSDVRQKCQDE 473
V+ E L + ++EL Q ++ + + + KL+ + +++ ++
Sbjct: 1829 VENEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNVLRLQDLVDKLQAKVKSYKRQAEEA 1888
Query: 474 TQMISSLKTQIQSQESDLKSQEDDLNRAKSELNRLQQEETQLEQSIQA 521
+ ++ ++ + + +L+ E+ + A+S++N+L+ + ++ I A
Sbjct: 1889 EEQSNANLSKFRKLQHELEEAEERADIAESQVNKLRVKSREVHTKISA 1936
>gi|36031016 CTCL tumor antigen L14-2 [Homo sapiens]
Length = 898
Score = 68.2 bits (165), Expect = 3e-11
Identities = 50/216 (23%), Positives = 100/216 (46%), Gaps = 19/216 (8%)
Query: 384 KELDDISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQ------- 436
KEL+ + +I QL +EK L Q KE + E+ +L+ D++ ++
Sbjct: 341 KELEKNTNKIKQLSQEKGRLHQLYETKEGETTRLIREIDKLKEDINSHVIKVKWAQNKLK 400
Query: 437 -ELEAQKQDAQDRLDEMDQQKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLKSQE 495
E+++ K+ +D+L E + + ++ +R+ CQD +KT +S+E +
Sbjct: 401 AEMDSHKE-TKDKLKETTTKLTQAKEEADQIRKNCQD------MIKTYQESEEIKSNELD 453
Query: 496 DDLNRAKSELNRLQQEETQLEQSIQAGRVQLETIIKSLKSTQDEINQARSKLSQLHESRQ 555
L K EL + QE++ + A +LE + ++ K DE+ R+K+ L + R
Sbjct: 454 AKLRVTKGELEKQMQEKSDQLEMHHAKIKELEDLKRTFKEGMDELRTLRTKVKCLEDERL 513
Query: 556 EAHRSLEQYDQVLDGAHGASLTDLANLSEGVSLAER 591
L +Y ++++ ++ NL + V A++
Sbjct: 514 RTEDELSKYKEIIN----RQKAEIQNLLDKVKTADQ 545
Score = 67.0 bits (162), Expect = 7e-11
Identities = 47/231 (20%), Positives = 115/231 (49%), Gaps = 29/231 (12%)
Query: 382 GVKELDDISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEAQ 441
G+ EL + ++ L+ E+ E ++ + +E I ++ +E+Q L + + ++L+
Sbjct: 494 GMDELRTLRTKVKCLEDERLRTEDELSKYKEIINRQKAEIQNLLDKVKTADQLQEQLQRG 553
Query: 442 KQDAQDRLDEMDQQKAKLRDMLSDVRQKCQDE------TQMISSLKTQIQSQESDLKSQE 495
KQ+ ++ +E++ + + D+ D+ + E T+ ++S Q+QS+ + L+SQ
Sbjct: 554 KQEIENLKEEVESLNSLINDLQKDIEGSRKRESELLLFTERLTSKNAQLQSESNSLQSQF 613
Query: 496 DDLNRAKSEL---------------NRLQQEETQLEQSIQAGRVQL---ETIIKSLKSTQ 537
D ++ ++S+L +RL +EE ++ +Q + +L +T +K+L +
Sbjct: 614 DKVSCSESQLQSQCEQMKQTNINLESRLLKEEELRKEEVQTLQAELACRQTEVKALSTQV 673
Query: 538 DE-----INQARSKLSQLHESRQEAHRSLEQYDQVLDGAHGASLTDLANLS 583
+E + Q R S + + ++ ++ + DQV G++ ++ + + S
Sbjct: 674 EELKDELVTQRRKHASSIKDLTKQLQQARRKLDQVESGSYDKEVSSMGSRS 724
Score = 52.8 bits (125), Expect = 1e-06
Identities = 38/181 (20%), Positives = 87/181 (48%), Gaps = 15/181 (8%)
Query: 387 DDISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQ-ELEAQKQDA 445
D + + +L + K +Q + ++ I+ + N+LD + + ELE Q Q+
Sbjct: 411 DKLKETTTKLTQAKEEADQIRKNCQDMIKTYQESEEIKSNELDAKLRVTKGELEKQMQEK 470
Query: 446 QDRLDEMDQQKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLKSQEDDLNRAKSEL 505
D+L+ AK+++ L D+++ ++ + +L+T+++ E + ED+L++ K +
Sbjct: 471 SDQLE---MHHAKIKE-LEDLKRTFKEGMDELRTLRTKVKCLEDERLRTEDELSKYKEII 526
Query: 506 NRLQQE----------ETQLEQSIQAGRVQLETIIKSLKSTQDEINQARSKLSQLHESRQ 555
NR + E QL++ +Q G+ ++E + + ++S IN + + +
Sbjct: 527 NRQKAEIQNLLDKVKTADQLQEQLQRGKQEIENLKEEVESLNSLINDLQKDIEGSRKRES 586
Query: 556 E 556
E
Sbjct: 587 E 587
Score = 46.2 bits (108), Expect = 1e-04
Identities = 37/206 (17%), Positives = 99/206 (48%), Gaps = 28/206 (13%)
Query: 383 VKELDDISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQN---DLDRET-SSLQEL 438
+KE + + EK +L ++++++ E +Q + +++L++ +L++E +S +L
Sbjct: 213 IKENKKHQELFVDICSEKDNLREELKKRTETEKQHMNTIKQLESRIEELNKEVKASRDQL 272
Query: 439 EAQKQDAQDRLDEMDQQKAKLRDMLSDVRQKCQDETQMISS--------------LKTQI 484
AQ A++ + ++ ++ A+ + +KC++ Q + L+ +
Sbjct: 273 IAQDVTAKNAVQQLHKEMAQ---RMEQANKKCEEARQEKEAMVMKYVRGEKESLDLRKEK 329
Query: 485 QSQESDLKSQEDDLNRAKSELNRLQQEETQLEQSIQAGRVQLETIIKSLKSTQDEINQ-- 542
++ E L+ +L + +++ +L QE+ +L Q + + +I+ + +++IN
Sbjct: 330 ETLEKKLRDANKELEKNTNKIKQLSQEKGRLHQLYETKEGETTRLIREIDKLKEDINSHV 389
Query: 543 -----ARSKLSQLHESRQEAHRSLEQ 563
A++KL +S +E L++
Sbjct: 390 IKVKWAQNKLKAEMDSHKETKDKLKE 415
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 67.8 bits (164), Expect = 4e-11
Identities = 46/191 (24%), Positives = 92/191 (48%), Gaps = 8/191 (4%)
Query: 387 DDISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEAQ-KQDA 445
DD+ + + +L++ K +LEQ + E + + + E+Q ++ R +LQ ++AQ ++D
Sbjct: 1514 DDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDL 1573
Query: 446 QDRLDEMDQQKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLKSQE---DDLNRAK 502
Q R ++ +++K +L + ++ + +DE + S + E DLK E D N+ +
Sbjct: 1574 QGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNR 1633
Query: 503 SE----LNRLQQEETQLEQSIQAGRVQLETIIKSLKSTQDEINQARSKLSQLHESRQEAH 558
E L +LQ + + + R E I+ K + ++ +++ QL E A
Sbjct: 1634 DEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAE 1693
Query: 559 RSLEQYDQVLD 569
R+ Q Q D
Sbjct: 1694 RAKRQAQQERD 1704
Score = 63.5 bits (153), Expect = 8e-10
Identities = 41/204 (20%), Positives = 102/204 (50%), Gaps = 3/204 (1%)
Query: 381 TGVKELDDISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEA 440
T + E ++ S+ +A+L+ + ++ D+ EE +R++ + QEL+ + +L
Sbjct: 1006 TNLTEEEEKSKSLAKLKNKHEAMITDL---EERLRREEKQRQELEKTRRKLEGDSTDLSD 1062
Query: 441 QKQDAQDRLDEMDQQKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLKSQEDDLNR 500
Q + Q ++ E+ Q AK + L + ++E + +I+ ES + ++DL
Sbjct: 1063 QIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLES 1122
Query: 501 AKSELNRLQQEETQLEQSIQAGRVQLETIIKSLKSTQDEINQARSKLSQLHESRQEAHRS 560
++ N+ ++++ L + ++A + +LE + S + Q+ ++ +++ L ++ +E ++
Sbjct: 1123 ERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKT 1182
Query: 561 LEQYDQVLDGAHGASLTDLANLSE 584
E Q + H ++ +LA E
Sbjct: 1183 HEAQIQEMRQKHSQAVEELAEQLE 1206
Score = 56.2 bits (134), Expect = 1e-07
Identities = 60/275 (21%), Positives = 121/275 (44%), Gaps = 55/275 (20%)
Query: 388 DISQEIAQLQREKYSLEQDIREKEEA---------------------IRQKTSEVQELQN 426
D+S +IA+LQ + L+ + +KEE IR+ S++ ELQ
Sbjct: 1059 DLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQE 1118
Query: 427 DLDRETSSLQELEAQKQDAQDRLDEMDQQKAKLRDML------SDVRQKCQDETQMI-SS 479
DL+ E +S + E QK+D + L+ + K +L D L ++R K + E ++ +
Sbjct: 1119 DLESERASRNKAEKQKRDLGEELEAL---KTELEDTLDSTAAQQELRSKREQEVNILKKT 1175
Query: 480 LKTQIQSQESDLKSQEDDLNRAKSEL-------NRLQQEETQLEQSIQAGRVQLETIIKS 532
L+ + ++ E+ ++ ++A EL R++ + +Q+++ R +L +K
Sbjct: 1176 LEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKV 1235
Query: 533 L-----------KSTQDEINQARSKLSQLHESRQEAHRSLEQYDQVLDGAHGASLTDLAN 581
L K + ++ + + K ++ R E + + LD ++T L +
Sbjct: 1236 LLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELD-----NVTGLLS 1290
Query: 582 LSEGVSLAERGSFGAMDDPFKN-KALLFSNNTQEL 615
S+ S F A++ ++ + LL N Q+L
Sbjct: 1291 QSDSKSSKLTKDFSALESQLQDTQELLQEENRQKL 1325
Score = 52.0 bits (123), Expect = 2e-06
Identities = 42/214 (19%), Positives = 97/214 (45%), Gaps = 28/214 (13%)
Query: 384 KELDDISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEAQKQ 443
+ELDD+ ++ ++ +LE+ ++ ++ + ++ + + + DR + +E E +
Sbjct: 1420 QELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKAL 1479
Query: 444 DAQDRLDEMDQQKAKLRDMLSDVRQKCQD---------------------ETQMISSLKT 482
L+E +QKA+L + R + +D Q + +KT
Sbjct: 1480 SLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKT 1539
Query: 483 QIQSQESDLKSQEDDLNRAKSELNRLQQEETQLEQSIQAGRVQLE----TIIKSLKSTQD 538
Q++ E +L++ ED + + E+N LQ + Q E+ +Q Q E +++ ++ +
Sbjct: 1540 QLEELEDELQATED--AKLRLEVN-LQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEA 1596
Query: 539 EINQARSKLSQLHESRQEAHRSLEQYDQVLDGAH 572
E+ R + S +R++ L+ + +D A+
Sbjct: 1597 ELEDERKQRSMAVAARKKLEMDLKDLEAHIDSAN 1630
Score = 50.8 bits (120), Expect = 5e-06
Identities = 45/211 (21%), Positives = 89/211 (42%), Gaps = 31/211 (14%)
Query: 384 KELDDISQEIAQLQREKYSLEQ-----------------DIREKEEAIRQKTSEVQELQN 426
++L+ + A L++ K +LE D K + + + E+Q N
Sbjct: 1203 EQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFN 1262
Query: 427 DLDRETSSLQE----LEAQKQDAQDRLDEMDQQKAKLRDMLSDVRQKCQDETQMISSLKT 482
+ +R + L + L+ + + L + D + +KL S + + QD +++
Sbjct: 1263 EGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENR 1322
Query: 483 QIQSQESDLKSQEDDLNRAKSELNRLQQEETQLEQSIQAGRVQLETIIKSLK------ST 536
Q S + LK ED+ N + +L ++ + LE+ I Q+ + K ++ T
Sbjct: 1323 QKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLET 1382
Query: 537 QDEINQARSK----LSQLHESRQEAHRSLEQ 563
+E+ + K LSQ HE + A+ LE+
Sbjct: 1383 AEEVKRKLQKDLEGLSQRHEEKVAAYDKLEK 1413
Score = 50.1 bits (118), Expect = 9e-06
Identities = 50/221 (22%), Positives = 103/221 (46%), Gaps = 40/221 (18%)
Query: 380 FTGVKELDDISQEIAQLQREKYSLEQDIREKEE----------AIRQKTSEVQELQNDLD 429
FT VK L +S++ E+++ KEE A + +E++ LQ+ L
Sbjct: 831 FTKVKPLLQVSRQ-----------EEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLM 879
Query: 430 RETSSLQE-LEAQKQ---DAQDRLDEMDQQKAKLRDMLSDVRQKCQDETQMISSLKTQIQ 485
E LQE L+A+ + +A++ + +K +L ++ D+ + ++E + L+ + +
Sbjct: 880 AEKLQLQEQLQAETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKK 939
Query: 486 SQESDLKSQEDDLNRAKSELNRLQQEETQLE---QSIQAGRVQLE----TIIKSLKSTQD 538
+ +++ E+ L +S +LQ E+ E + ++ ++ LE + K K +D
Sbjct: 940 KMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLED 999
Query: 539 EINQARSKLSQLHESRQEAHRSLEQYDQVLDGAHGASLTDL 579
I + + L++ +E +SL + L H A +TDL
Sbjct: 1000 RIAEFTTNLTE----EEEKSKSLAK----LKNKHEAMITDL 1032
Score = 49.7 bits (117), Expect = 1e-05
Identities = 40/201 (19%), Positives = 91/201 (45%), Gaps = 14/201 (6%)
Query: 363 ERGTPGPDSSGSLGSGEFTGVKELDDISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQ 422
ER + + S G G ++E + IAQL+ E + + + +++ ++
Sbjct: 1702 ERDELADEIANSSGKGALA-LEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQID 1760
Query: 423 ELQNDLDRETSSLQELEAQKQDAQDRLDEMDQQKAKLRDMLSDVRQKCQDETQMISSLKT 482
++ DL+ E S Q+ E +Q + + E+ K KL++M V+ K K
Sbjct: 1761 QINTDLNLERSHAQKNENARQQLERQNKEL---KVKLQEMEGTVKSK----------YKA 1807
Query: 483 QIQSQESDLKSQEDDLNRAKSELNRLQQEETQLEQSIQAGRVQLETIIKSLKSTQDEINQ 542
I + E+ + E+ L+ E ++ + E+ ++ +Q++ ++ + +D+ ++
Sbjct: 1808 SITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADK 1867
Query: 543 ARSKLSQLHESRQEAHRSLEQ 563
A ++L QL +EA ++
Sbjct: 1868 ASTRLKQLKRQLEEAEEEAQR 1888
Score = 48.5 bits (114), Expect = 3e-05
Identities = 40/195 (20%), Positives = 90/195 (46%), Gaps = 15/195 (7%)
Query: 394 AQLQREKYSLEQDIR-------EKEEAIRQKTSEVQELQNDLDRETSSLQELEAQKQDAQ 446
+QL EK L++ ++ E EE + T++ QEL+ +LEA+ ++ +
Sbjct: 876 SQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQELE-------EICHDLEARVEEEE 928
Query: 447 DRLDEMDQQKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLKSQEDDLNRAKSELN 506
+R + +K K++ + ++ ++ ++E L+ + + E+ LK E++ + +
Sbjct: 929 ERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNC 988
Query: 507 RLQQEETQLEQSIQAGRVQLETIIKSLKSTQDEINQARSKLSQLHESRQEAHRSLEQYDQ 566
+L +E+ LE I L + KS N+ + ++ L E + + ++ ++
Sbjct: 989 KLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEK 1048
Query: 567 VLDGAHGASLTDLAN 581
G S TDL++
Sbjct: 1049 TRRKLEGDS-TDLSD 1062
Score = 46.6 bits (109), Expect = 1e-04
Identities = 36/184 (19%), Positives = 78/184 (42%), Gaps = 14/184 (7%)
Query: 385 ELDDISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEAQKQD 444
ELD+++ ++Q + L +D A+ + + QEL LQE QK
Sbjct: 1281 ELDNVTGLLSQSDSKSSKLTKDF----SALESQLQDTQEL----------LQEENRQKLS 1326
Query: 445 AQDRLDEMDQQKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLKSQEDDLNRAKSE 504
+L +++ +K R+ L + + + + I++L Q+ + ++ L A+
Sbjct: 1327 LSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEV 1386
Query: 505 LNRLQQEETQLEQSIQAGRVQLETIIKSLKSTQDEINQARSKLSQLHESRQEAHRSLEQY 564
+LQ++ L Q + + + K+ Q E++ L +S + +++
Sbjct: 1387 KRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKF 1446
Query: 565 DQVL 568
DQ+L
Sbjct: 1447 DQLL 1450
Score = 45.4 bits (106), Expect = 2e-04
Identities = 47/224 (20%), Positives = 91/224 (40%), Gaps = 37/224 (16%)
Query: 385 ELDDISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEAQKQD 444
EL+D ++ + + LE D+++ E + + + D L++L+AQ +D
Sbjct: 1597 ELEDERKQRSMAVAARKKLEMDLKDLE-------AHIDSANKNRDEAIKQLRKLQAQMKD 1649
Query: 445 AQDRLD-----------EMDQQKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLKS 493
LD + + + KL+ M +++ Q Q+E K Q Q + +L
Sbjct: 1650 CMRELDDTRASREEILAQAKENEKKLKSMEAEMIQ-LQEELAAAERAKRQAQQERDELAD 1708
Query: 494 QEDDLN----RAKSELNRLQQEETQLEQSIQAGRVQLETIIKSLKSTQDEINQARSKLS- 548
+ + + A E RL+ QLE+ ++ + E I LK +I+Q + L+
Sbjct: 1709 EIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNL 1768
Query: 549 -------------QLHESRQEAHRSLEQYDQVLDGAHGASLTDL 579
QL +E L++ + + + AS+T L
Sbjct: 1769 ERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITAL 1812
Score = 40.0 bits (92), Expect = 0.009
Identities = 41/208 (19%), Positives = 85/208 (40%), Gaps = 27/208 (12%)
Query: 385 ELDDISQEIA-------QLQREKYSLEQDIREKE-------EAIRQKTSEVQELQNDLDR 430
E+ + +E+A Q Q+E+ L +I E R+ + + +L+ +L+
Sbjct: 1681 EMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEE 1740
Query: 431 ETSSLQELEAQKQDAQDRLDEMDQQKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQESD 490
E + + + + + A ++D+++ R Q + LK ++Q E
Sbjct: 1741 EQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGT 1800
Query: 491 LKSQEDDLNRAKSELNRLQQEETQLEQSI-------QAGRVQLETIIKSLKSTQDEINQA 543
+KS + K+ + L+ + QLE+ + QA Q+ K LK +++
Sbjct: 1801 VKS------KYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDE 1854
Query: 544 RSKLSQLHESRQEAHRSLEQYDQVLDGA 571
R Q + +A L+Q + L+ A
Sbjct: 1855 RRNAEQYKDQADKASTRLKQLKRQLEEA 1882
Score = 38.9 bits (89), Expect = 0.021
Identities = 38/189 (20%), Positives = 81/189 (42%), Gaps = 25/189 (13%)
Query: 395 QLQREKYSLEQDIREKEEAIRQK--------TSEVQELQNDLDRETSSLQELEAQKQDAQ 446
QL+R+ L+ ++E E ++ K +++ +L+ LD ET ++ Q
Sbjct: 1782 QLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNET----------KERQ 1831
Query: 447 DRLDEMDQQKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLKSQEDDLNRAKSELN 506
++ + + KL+D+L + DE + K Q + LK + L A+ E
Sbjct: 1832 AACKQVRRTEKKLKDVLL----QVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQ 1887
Query: 507 RLQQEETQLEQSIQAGRVQLETIIKSLKSTQDEINQARSKLSQLHESRQEAHRSLEQYDQ 566
R +L++ ++ + + + + S ++++ R L + R + + D+
Sbjct: 1888 RANASRRKLQRELEDATETADAMNREVSSLKNKLR--RGDLPFVVPRRMARKGAGDGSDE 1945
Query: 567 VLDG-AHGA 574
+DG A GA
Sbjct: 1946 EVDGKADGA 1954
Score = 33.9 bits (76), Expect = 0.67
Identities = 44/232 (18%), Positives = 94/232 (40%), Gaps = 58/232 (25%)
Query: 384 KELDDISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSS----LQELE 439
K+ D+ +E+ L+ E ++E ++ EV L+ L+ E + +QE+
Sbjct: 1132 KQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMR 1191
Query: 440 AQKQDAQDRLDEMDQQKAKLRDMLSDVRQKCQDETQMISS------------------LK 481
+ A + L E +Q +++ L +Q ++E +++ ++
Sbjct: 1192 QKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVE 1251
Query: 482 TQIQSQESDLKSQEDD-----------------------LNRAKSELNRLQQEETQLEQS 518
Q+ QE +K E + L+++ S+ ++L ++ + LE
Sbjct: 1252 AQL--QELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQ 1309
Query: 519 IQAGRVQLE-------TIIKSLKSTQDEINQARSKLSQLHESRQEAHRSLEQ 563
+Q + L+ ++ LK +DE N R +L E +EA +LE+
Sbjct: 1310 LQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQL----EEEEEAKHNLEK 1357
>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 67.8 bits (164), Expect = 4e-11
Identities = 49/210 (23%), Positives = 108/210 (51%), Gaps = 22/210 (10%)
Query: 384 KELDDISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEAQKQ 443
K++DD+ +A++++EK++ E ++ + ++ + + E L +E +LQE Q
Sbjct: 958 KDIDDLELTLAKVEKEKHATENKVKN----LTEEMAGLDETIAKLTKEKKALQEAHQQTL 1013
Query: 444 D----AQDRLDEMDQQKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLKSQED--- 496
D +D+++ + + K KL + D+ + E ++ L+ + E DLK ++
Sbjct: 1014 DDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIM 1073
Query: 497 DLNRAKSELN-RLQQEETQLE------QSIQAGRVQLETIIKSLKS----TQDEINQARS 545
D+ K +L+ +L+++E ++ + QA +QL+ IK L++ ++EI R+
Sbjct: 1074 DIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERA 1133
Query: 546 KLSQLHESRQEAHRSLEQYDQVLDGAHGAS 575
++ + R + R LE+ + L+ A GA+
Sbjct: 1134 SRAKAEKQRSDLSRELEEISERLEEAGGAT 1163
Score = 52.8 bits (125), Expect = 1e-06
Identities = 38/200 (19%), Positives = 97/200 (48%), Gaps = 21/200 (10%)
Query: 384 KELDDISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEAQKQ 443
KE+ + +E +++ E E +E EE + E +LQ + E L
Sbjct: 853 KEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLA------- 905
Query: 444 DAQDRLDEMDQQKAKLRDMLSDVRQKCQDETQM---ISSLKTQIQSQESDLKSQEDDL-- 498
DA++R D++ + K +L + +V ++ +DE ++ +++ K +++ + S+LK DDL
Sbjct: 906 DAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLEL 965
Query: 499 ---------NRAKSELNRLQQEETQLEQSIQAGRVQLETIIKSLKSTQDEINQARSKLSQ 549
+ ++++ L +E L+++I + + + ++ + T D++ K++
Sbjct: 966 TLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNT 1025
Query: 550 LHESRQEAHRSLEQYDQVLD 569
L +++ + + ++ + L+
Sbjct: 1026 LTKAKIKLEQQVDDLEGSLE 1045
Score = 50.1 bits (118), Expect = 9e-06
Identities = 46/240 (19%), Positives = 110/240 (45%), Gaps = 31/240 (12%)
Query: 370 DSSGSLGSGEFTGVKELDDISQEIAQ-------LQREKYSLEQDIREKEEAIRQKTSEVQ 422
D +L + +++DD+ + Q L+R K LE D++ +E+I +E Q
Sbjct: 1021 DKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQ 1080
Query: 423 ELQNDLDRETSSLQELEAQKQDAQDRLDEMDQQKAKLRDMLSDVRQKCQDETQMISSLKT 482
+L L ++ + L+++ +D Q ++ ++ +L+ + ++ ++ + E + +
Sbjct: 1081 QLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAE----RASRA 1136
Query: 483 QIQSQESDLKSQEDDLNR----------AKSELNRLQQEETQ-LEQSIQAGRVQLETIIK 531
+ + Q SDL + ++++ A+ E+N+ ++ E Q + + ++ +Q E
Sbjct: 1137 KAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAA 1196
Query: 532 SL-KSTQDEINQARSKLSQLHESRQEAHRSLEQYDQVLDGAHGASLTDLANLSEGVSLAE 590
+L K D + + ++ L +Q+ + + +D DLA+ E VS A+
Sbjct: 1197 TLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEID--------DLASNVETVSKAK 1248
Score = 48.9 bits (115), Expect = 2e-05
Identities = 44/208 (21%), Positives = 94/208 (45%), Gaps = 18/208 (8%)
Query: 386 LDDISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEAQKQDA 445
L D + QL + K LE I+E + ++ + +E+ +L T+ ++LE + +
Sbjct: 904 LADAEERCDQLIKTKIQLEAKIKE----VTERAEDEEEINAEL---TAKKRKLEDECSEL 956
Query: 446 QDRLDEMDQQKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLKSQE-------DDL 498
+ +D+++ AK+ K ++ T+ ++ L I + K+ + DDL
Sbjct: 957 KKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDL 1016
Query: 499 NRAKSELNRLQQEETQLEQSIQAGRVQLETIIKSLKSTQDEINQARSKLSQLHESRQEAH 558
+ ++N L + + +LEQ + LE ++ K + ++ +A+ KL + QE+
Sbjct: 1017 QAEEDKVNTLTKAKIKLEQQVD----DLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESI 1072
Query: 559 RSLEQYDQVLDGAHGASLTDLANLSEGV 586
+E Q LD +++NL +
Sbjct: 1073 MDIENEKQQLDEKLKKKEFEISNLQSKI 1100
Score = 48.9 bits (115), Expect = 2e-05
Identities = 51/247 (20%), Positives = 107/247 (43%), Gaps = 37/247 (14%)
Query: 374 SLGSGEFTGVKELDDISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETS 433
SLG+ F ++ ++ L+RE +L+Q+I + E I + + EL+ +
Sbjct: 1482 SLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQ 1541
Query: 434 SLQELEAQKQDAQDRLDEMDQQ----KAKLRDMLSDVRQKCQDETQMISSLKTQ----IQ 485
EL+A ++A+ L+ + + + +L + S+V +K ++ + I LK ++
Sbjct: 1542 EKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVE 1601
Query: 486 SQESDL--------------KSQEDDLNRAKSEL---NRLQQEETQLEQSIQA----GRV 524
S +S L K E DLN + +L NR+ E + ++ Q ++
Sbjct: 1602 SMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQI 1661
Query: 525 QLETIIKSLKSTQDEINQARSKLSQLHESRQEAHRSLEQYD--------QVLDGAHGASL 576
L+ ++S + ++++ + + L +E +LEQ + ++LD + L
Sbjct: 1662 HLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQL 1721
Query: 577 TDLANLS 583
N S
Sbjct: 1722 LHTQNTS 1728
Score = 48.5 bits (114), Expect = 3e-05
Identities = 39/182 (21%), Positives = 77/182 (42%), Gaps = 14/182 (7%)
Query: 388 DISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEAQKQDAQD 447
D Q +L+ K L Q ++ EE + ++ L+ R + +++L +
Sbjct: 1384 DAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNA 1443
Query: 448 RLDEMDQQKAKLRDMLSDVRQKCQD-------ETQMISSLKTQIQSQESDLKSQEDDLNR 500
+D+++ +L++ +QKC++ + SL T++ ++ + D L
Sbjct: 1444 ACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLET 1503
Query: 501 AKSELNRLQQEETQLEQSIQAGRVQLETIIKSLKSTQDEINQARSKLSQLHESRQEAHRS 560
K E LQQE + L + I G ++ + K K + E +L + +EA S
Sbjct: 1504 LKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQE-------KCELQAALEEAEAS 1556
Query: 561 LE 562
LE
Sbjct: 1557 LE 1558
Score = 45.4 bits (106), Expect = 2e-04
Identities = 36/206 (17%), Positives = 91/206 (44%), Gaps = 13/206 (6%)
Query: 370 DSSGSLGSGEFTGVKELDDISQEIAQLQREKYSLEQDIREKEEAIRQK-------TSEVQ 422
D L S E + ++D++ + +LQ E + + EKE + Q T +++
Sbjct: 1260 DQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIE 1319
Query: 423 ELQNDLDRETSSLQELEAQKQDAQDRLDEMDQQKAKLRDMLSDVRQKCQDETQMISSLKT 482
EL+ L+ E + L Q ++ D + +Q + ++ +++++ ++ +T
Sbjct: 1320 ELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRT 1379
Query: 483 QIQSQESDLKSQEDDLNRAKSELNRLQQEETQLEQSIQAGRVQLETIIKSLKSTQDEINQ 542
+ E+D + ++L AK +L Q E+ ++A + ++ K+ + Q+E+
Sbjct: 1380 K---YETDAIQRTEELEEAK---KKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVED 1433
Query: 543 ARSKLSQLHESRQEAHRSLEQYDQVL 568
+ + + + + +D++L
Sbjct: 1434 LMLDVERTNAACAALDKKQRNFDKIL 1459
Score = 45.1 bits (105), Expect = 3e-04
Identities = 39/194 (20%), Positives = 89/194 (45%), Gaps = 15/194 (7%)
Query: 384 KELDDISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEA--Q 441
K+ D+S+E+ ++ + E +++ +E Q+++ DL+ T + A +
Sbjct: 1140 KQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLR 1199
Query: 442 KQDAQ------DRLDEMDQQKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLKSQE 495
K+ A +++D + + K KL S+++ + D + ++ + E ++ E
Sbjct: 1200 KKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLE 1259
Query: 496 DDLNRAKSELNRLQQEETQLEQSIQAGRVQLETIIKSLKSTQDEINQARSKLSQLHESRQ 555
D L+ KS+ ++E+ +L + A R +L+T DE + +SQL +Q
Sbjct: 1260 DQLSELKSK----EEEQQRLINDLTAQRGRLQTESGEFSRQLDE---KEALVSQLSRGKQ 1312
Query: 556 EAHRSLEQYDQVLD 569
+ +E+ + L+
Sbjct: 1313 AFTQQIEELKRQLE 1326
Score = 43.9 bits (102), Expect = 6e-04
Identities = 35/175 (20%), Positives = 85/175 (48%), Gaps = 12/175 (6%)
Query: 409 EKEEAIRQKTSEVQELQNDLDRETSSLQELEAQKQDAQDRLDEMDQQKAKLRDMLSDVRQ 468
E E+ + E Q+++++L + + +ELE + +++ Q + L+D +
Sbjct: 850 ETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEE 909
Query: 469 KCQDETQMISSLKTQIQSQESDLKSQEDDLNRAKSEL----NRLQQEETQLEQSIQAGRV 524
+C Q+I + K Q++++ ++ + +D +EL +L+ E ++L++ I +
Sbjct: 910 RCD---QLIKT-KIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLEL 965
Query: 525 QLETIIKSLKSTQDEINQARSKLSQLHESRQEAHRSLEQYDQVLDGAHGASLTDL 579
L + K +T++++ +++ L E+ + L + + L AH +L DL
Sbjct: 966 TLAKVEKEKHATENKVKNLTEEMAGLDETIAK----LTKEKKALQEAHQQTLDDL 1016
Score = 42.7 bits (99), Expect = 0.001
Identities = 48/239 (20%), Positives = 106/239 (44%), Gaps = 35/239 (14%)
Query: 384 KELDDISQEIAQLQRE--------KYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSL 435
+++ + +EI QL+R + +L+ +IR + +AIR K +L N+++ + +
Sbjct: 1580 RKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDL-NEMEIQLNHA 1638
Query: 436 QELEAQK-----------QDAQDRLDEMDQQKAKLRDMLSDVRQKCQDETQMISSLKTQI 484
+ A+ +D Q LD+ + + L++ L+ V ++ I L+ +
Sbjct: 1639 NRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATL 1698
Query: 485 QSQESDLKSQEDDLNRAKSELNRLQQEET-------QLEQSIQAGRVQLETIIKSLKSTQ 537
+ E K E +L A + L + T +LE I + ++E I++ ++ +
Sbjct: 1699 EQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAE 1758
Query: 538 DEINQARSKLSQLHE---SRQEAHRSLEQYDQVLDGAHGASLTDL-ANLSEGVSLAERG 592
++ +A + + + E Q+ LE+ + ++ ++ DL L E LA +G
Sbjct: 1759 EKAKKAITDAAMMAEELKKEQDTSAHLERMKKNME----QTVKDLQLRLDEAEQLALKG 1813
Score = 41.6 bits (96), Expect = 0.003
Identities = 29/179 (16%), Positives = 88/179 (49%), Gaps = 10/179 (5%)
Query: 384 KELDDISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEAQKQ 443
K+ + + +A+ +++ ++ ++ R +E+ +++N + L+ L+ + +
Sbjct: 1450 KKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENK 1509
Query: 444 DAQDRLDEMDQQKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLKSQED------- 496
+ Q + ++ +Q A+ + ++ + + Q L+ ++ E+ L+ +E
Sbjct: 1510 NLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQL 1569
Query: 497 DLNRAKSELNRLQQEETQLEQSIQAGRVQLETIIKSLKSTQDEINQARSKLSQLHESRQ 555
+LN+ KSE++R E+ + ++ ++ I++S++ST D ++R+ +L + +
Sbjct: 1570 ELNQVKSEVDRKIAEKDEEIDQLKRNHIR---IVESMQSTLDAEIRSRNDAIRLKKKME 1625
Score = 30.0 bits (66), Expect = 9.6
Identities = 18/123 (14%), Positives = 59/123 (47%), Gaps = 7/123 (5%)
Query: 404 EQDIREKEEAIRQKTSEVQ-------ELQNDLDRETSSLQELEAQKQDAQDRLDEMDQQK 456
++ I++ E +R+ EV+ E L + ++EL Q ++ + + +
Sbjct: 1815 KKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLV 1874
Query: 457 AKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLKSQEDDLNRAKSELNRLQQEETQLE 516
KL+ + +++ ++ + ++ + + + +L+ E+ + A+S++N+L+ + ++
Sbjct: 1875 DKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQVNKLRVKSREVH 1934
Query: 517 QSI 519
+
Sbjct: 1935 TKV 1937
>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 67.8 bits (164), Expect = 4e-11
Identities = 49/210 (23%), Positives = 108/210 (51%), Gaps = 22/210 (10%)
Query: 384 KELDDISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEAQKQ 443
K++DD+ +A++++EK++ E ++ + ++ + + E L +E +LQE Q
Sbjct: 958 KDIDDLELTLAKVEKEKHATENKVKN----LTEEMAGLDETIAKLTKEKKALQEAHQQTL 1013
Query: 444 D----AQDRLDEMDQQKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLKSQED--- 496
D +D+++ + + K KL + D+ + E ++ L+ + E DLK ++
Sbjct: 1014 DDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIM 1073
Query: 497 DLNRAKSELN-RLQQEETQLE------QSIQAGRVQLETIIKSLKS----TQDEINQARS 545
D+ K +L+ +L+++E ++ + QA +QL+ IK L++ ++EI R+
Sbjct: 1074 DIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERA 1133
Query: 546 KLSQLHESRQEAHRSLEQYDQVLDGAHGAS 575
++ + R + R LE+ + L+ A GA+
Sbjct: 1134 SRAKAEKQRSDLSRELEEISERLEEAGGAT 1163
Score = 52.8 bits (125), Expect = 1e-06
Identities = 38/200 (19%), Positives = 97/200 (48%), Gaps = 21/200 (10%)
Query: 384 KELDDISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEAQKQ 443
KE+ + +E +++ E E +E EE + E +LQ + E L
Sbjct: 853 KEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLA------- 905
Query: 444 DAQDRLDEMDQQKAKLRDMLSDVRQKCQDETQM---ISSLKTQIQSQESDLKSQEDDL-- 498
DA++R D++ + K +L + +V ++ +DE ++ +++ K +++ + S+LK DDL
Sbjct: 906 DAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLEL 965
Query: 499 ---------NRAKSELNRLQQEETQLEQSIQAGRVQLETIIKSLKSTQDEINQARSKLSQ 549
+ ++++ L +E L+++I + + + ++ + T D++ K++
Sbjct: 966 TLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNT 1025
Query: 550 LHESRQEAHRSLEQYDQVLD 569
L +++ + + ++ + L+
Sbjct: 1026 LTKAKIKLEQQVDDLEGSLE 1045
Score = 50.1 bits (118), Expect = 9e-06
Identities = 46/240 (19%), Positives = 110/240 (45%), Gaps = 31/240 (12%)
Query: 370 DSSGSLGSGEFTGVKELDDISQEIAQ-------LQREKYSLEQDIREKEEAIRQKTSEVQ 422
D +L + +++DD+ + Q L+R K LE D++ +E+I +E Q
Sbjct: 1021 DKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQ 1080
Query: 423 ELQNDLDRETSSLQELEAQKQDAQDRLDEMDQQKAKLRDMLSDVRQKCQDETQMISSLKT 482
+L L ++ + L+++ +D Q ++ ++ +L+ + ++ ++ + E + +
Sbjct: 1081 QLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAE----RASRA 1136
Query: 483 QIQSQESDLKSQEDDLNR----------AKSELNRLQQEETQ-LEQSIQAGRVQLETIIK 531
+ + Q SDL + ++++ A+ E+N+ ++ E Q + + ++ +Q E
Sbjct: 1137 KAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAA 1196
Query: 532 SL-KSTQDEINQARSKLSQLHESRQEAHRSLEQYDQVLDGAHGASLTDLANLSEGVSLAE 590
+L K D + + ++ L +Q+ + + +D DLA+ E VS A+
Sbjct: 1197 TLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEID--------DLASNVETVSKAK 1248
Score = 48.9 bits (115), Expect = 2e-05
Identities = 44/208 (21%), Positives = 94/208 (45%), Gaps = 18/208 (8%)
Query: 386 LDDISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEAQKQDA 445
L D + QL + K LE I+E + ++ + +E+ +L T+ ++LE + +
Sbjct: 904 LADAEERCDQLIKTKIQLEAKIKE----VTERAEDEEEINAEL---TAKKRKLEDECSEL 956
Query: 446 QDRLDEMDQQKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLKSQE-------DDL 498
+ +D+++ AK+ K ++ T+ ++ L I + K+ + DDL
Sbjct: 957 KKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDL 1016
Query: 499 NRAKSELNRLQQEETQLEQSIQAGRVQLETIIKSLKSTQDEINQARSKLSQLHESRQEAH 558
+ ++N L + + +LEQ + LE ++ K + ++ +A+ KL + QE+
Sbjct: 1017 QAEEDKVNTLTKAKIKLEQQVD----DLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESI 1072
Query: 559 RSLEQYDQVLDGAHGASLTDLANLSEGV 586
+E Q LD +++NL +
Sbjct: 1073 MDIENEKQQLDEKLKKKEFEISNLQSKI 1100
Score = 48.9 bits (115), Expect = 2e-05
Identities = 51/247 (20%), Positives = 107/247 (43%), Gaps = 37/247 (14%)
Query: 374 SLGSGEFTGVKELDDISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETS 433
SLG+ F ++ ++ L+RE +L+Q+I + E I + + EL+ +
Sbjct: 1482 SLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQ 1541
Query: 434 SLQELEAQKQDAQDRLDEMDQQ----KAKLRDMLSDVRQKCQDETQMISSLKTQ----IQ 485
EL+A ++A+ L+ + + + +L + S+V +K ++ + I LK ++
Sbjct: 1542 EKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVE 1601
Query: 486 SQESDL--------------KSQEDDLNRAKSEL---NRLQQEETQLEQSIQA----GRV 524
S +S L K E DLN + +L NR+ E + ++ Q ++
Sbjct: 1602 SMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQI 1661
Query: 525 QLETIIKSLKSTQDEINQARSKLSQLHESRQEAHRSLEQYD--------QVLDGAHGASL 576
L+ ++S + ++++ + + L +E +LEQ + ++LD + L
Sbjct: 1662 HLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQL 1721
Query: 577 TDLANLS 583
N S
Sbjct: 1722 LHTQNTS 1728
Score = 48.5 bits (114), Expect = 3e-05
Identities = 39/182 (21%), Positives = 77/182 (42%), Gaps = 14/182 (7%)
Query: 388 DISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEAQKQDAQD 447
D Q +L+ K L Q ++ EE + ++ L+ R + +++L +
Sbjct: 1384 DAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNA 1443
Query: 448 RLDEMDQQKAKLRDMLSDVRQKCQD-------ETQMISSLKTQIQSQESDLKSQEDDLNR 500
+D+++ +L++ +QKC++ + SL T++ ++ + D L
Sbjct: 1444 ACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLET 1503
Query: 501 AKSELNRLQQEETQLEQSIQAGRVQLETIIKSLKSTQDEINQARSKLSQLHESRQEAHRS 560
K E LQQE + L + I G ++ + K K + E +L + +EA S
Sbjct: 1504 LKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQE-------KCELQAALEEAEAS 1556
Query: 561 LE 562
LE
Sbjct: 1557 LE 1558
Score = 45.4 bits (106), Expect = 2e-04
Identities = 36/206 (17%), Positives = 91/206 (44%), Gaps = 13/206 (6%)
Query: 370 DSSGSLGSGEFTGVKELDDISQEIAQLQREKYSLEQDIREKEEAIRQK-------TSEVQ 422
D L S E + ++D++ + +LQ E + + EKE + Q T +++
Sbjct: 1260 DQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIE 1319
Query: 423 ELQNDLDRETSSLQELEAQKQDAQDRLDEMDQQKAKLRDMLSDVRQKCQDETQMISSLKT 482
EL+ L+ E + L Q ++ D + +Q + ++ +++++ ++ +T
Sbjct: 1320 ELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRT 1379
Query: 483 QIQSQESDLKSQEDDLNRAKSELNRLQQEETQLEQSIQAGRVQLETIIKSLKSTQDEINQ 542
+ E+D + ++L AK +L Q E+ ++A + ++ K+ + Q+E+
Sbjct: 1380 K---YETDAIQRTEELEEAK---KKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVED 1433
Query: 543 ARSKLSQLHESRQEAHRSLEQYDQVL 568
+ + + + + +D++L
Sbjct: 1434 LMLDVERTNAACAALDKKQRNFDKIL 1459
Score = 45.1 bits (105), Expect = 3e-04
Identities = 39/194 (20%), Positives = 89/194 (45%), Gaps = 15/194 (7%)
Query: 384 KELDDISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEA--Q 441
K+ D+S+E+ ++ + E +++ +E Q+++ DL+ T + A +
Sbjct: 1140 KQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLR 1199
Query: 442 KQDAQ------DRLDEMDQQKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLKSQE 495
K+ A +++D + + K KL S+++ + D + ++ + E ++ E
Sbjct: 1200 KKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLE 1259
Query: 496 DDLNRAKSELNRLQQEETQLEQSIQAGRVQLETIIKSLKSTQDEINQARSKLSQLHESRQ 555
D L+ KS+ ++E+ +L + A R +L+T DE + +SQL +Q
Sbjct: 1260 DQLSELKSK----EEEQQRLINDLTAQRGRLQTESGEFSRQLDE---KEALVSQLSRGKQ 1312
Query: 556 EAHRSLEQYDQVLD 569
+ +E+ + L+
Sbjct: 1313 AFTQQIEELKRQLE 1326
Score = 43.9 bits (102), Expect = 6e-04
Identities = 35/175 (20%), Positives = 85/175 (48%), Gaps = 12/175 (6%)
Query: 409 EKEEAIRQKTSEVQELQNDLDRETSSLQELEAQKQDAQDRLDEMDQQKAKLRDMLSDVRQ 468
E E+ + E Q+++++L + + +ELE + +++ Q + L+D +
Sbjct: 850 ETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEE 909
Query: 469 KCQDETQMISSLKTQIQSQESDLKSQEDDLNRAKSEL----NRLQQEETQLEQSIQAGRV 524
+C Q+I + K Q++++ ++ + +D +EL +L+ E ++L++ I +
Sbjct: 910 RCD---QLIKT-KIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLEL 965
Query: 525 QLETIIKSLKSTQDEINQARSKLSQLHESRQEAHRSLEQYDQVLDGAHGASLTDL 579
L + K +T++++ +++ L E+ + L + + L AH +L DL
Sbjct: 966 TLAKVEKEKHATENKVKNLTEEMAGLDETIAK----LTKEKKALQEAHQQTLDDL 1016
Score = 42.7 bits (99), Expect = 0.001
Identities = 48/239 (20%), Positives = 106/239 (44%), Gaps = 35/239 (14%)
Query: 384 KELDDISQEIAQLQRE--------KYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSL 435
+++ + +EI QL+R + +L+ +IR + +AIR K +L N+++ + +
Sbjct: 1580 RKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDL-NEMEIQLNHA 1638
Query: 436 QELEAQK-----------QDAQDRLDEMDQQKAKLRDMLSDVRQKCQDETQMISSLKTQI 484
+ A+ +D Q LD+ + + L++ L+ V ++ I L+ +
Sbjct: 1639 NRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATL 1698
Query: 485 QSQESDLKSQEDDLNRAKSELNRLQQEET-------QLEQSIQAGRVQLETIIKSLKSTQ 537
+ E K E +L A + L + T +LE I + ++E I++ ++ +
Sbjct: 1699 EQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAE 1758
Query: 538 DEINQARSKLSQLHE---SRQEAHRSLEQYDQVLDGAHGASLTDL-ANLSEGVSLAERG 592
++ +A + + + E Q+ LE+ + ++ ++ DL L E LA +G
Sbjct: 1759 EKAKKAITDAAMMAEELKKEQDTSAHLERMKKNME----QTVKDLQLRLDEAEQLALKG 1813
Score = 41.6 bits (96), Expect = 0.003
Identities = 29/179 (16%), Positives = 88/179 (49%), Gaps = 10/179 (5%)
Query: 384 KELDDISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEAQKQ 443
K+ + + +A+ +++ ++ ++ R +E+ +++N + L+ L+ + +
Sbjct: 1450 KKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENK 1509
Query: 444 DAQDRLDEMDQQKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLKSQED------- 496
+ Q + ++ +Q A+ + ++ + + Q L+ ++ E+ L+ +E
Sbjct: 1510 NLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQL 1569
Query: 497 DLNRAKSELNRLQQEETQLEQSIQAGRVQLETIIKSLKSTQDEINQARSKLSQLHESRQ 555
+LN+ KSE++R E+ + ++ ++ I++S++ST D ++R+ +L + +
Sbjct: 1570 ELNQVKSEVDRKIAEKDEEIDQLKRNHIR---IVESMQSTLDAEIRSRNDAIRLKKKME 1625
Score = 30.0 bits (66), Expect = 9.6
Identities = 18/123 (14%), Positives = 59/123 (47%), Gaps = 7/123 (5%)
Query: 404 EQDIREKEEAIRQKTSEVQ-------ELQNDLDRETSSLQELEAQKQDAQDRLDEMDQQK 456
++ I++ E +R+ EV+ E L + ++EL Q ++ + + +
Sbjct: 1815 KKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLV 1874
Query: 457 AKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLKSQEDDLNRAKSELNRLQQEETQLE 516
KL+ + +++ ++ + ++ + + + +L+ E+ + A+S++N+L+ + ++
Sbjct: 1875 DKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQVNKLRVKSREVH 1934
Query: 517 QSI 519
+
Sbjct: 1935 TKV 1937
>gi|38044112 restin isoform b [Homo sapiens]
Length = 1392
Score = 66.6 bits (161), Expect = 9e-11
Identities = 36/180 (20%), Positives = 95/180 (52%), Gaps = 6/180 (3%)
Query: 384 KELDDISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEAQKQ 443
KEL + ++ A+ E S+++ ++E + QK + L +DL++ +L ++EA+ +
Sbjct: 805 KELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFR 864
Query: 444 DAQDRLDEMDQQKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLKSQEDDLNRAKS 503
+ +R +++ + K KL + ++++ + D + ++ + +++ +E D++ + L +A
Sbjct: 865 EKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANE 924
Query: 504 ELNRLQQEETQLEQSIQAGRVQLETIIKSLKSTQDEINQARSKLSQLHESRQEAHRSLEQ 563
+ LQ+ + +++A + Q E + K ++E + KLS L + + +H ++
Sbjct: 925 NASFLQKSIE--DMTVKAEQSQQE----AAKKHEEEKKELERKLSDLEKKMETSHNQCQE 978
Score = 49.7 bits (117), Expect = 1e-05
Identities = 35/197 (17%), Positives = 95/197 (48%), Gaps = 17/197 (8%)
Query: 385 ELDDISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEAQKQD 444
+L ++ + ++++ + K +LE++++ +E + + E +Q + + L + E Q
Sbjct: 785 KLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQ--- 841
Query: 445 AQDRLDEMDQQKAKLRDMLSDV----RQKCQDETQMISSLKTQIQSQESDLKSQEDD--- 497
+ + KLR+ L+D+ R+K + E Q+I + K ++++ +++ D
Sbjct: 842 ----FNMLSSDLEKLRENLADMEAKFREKDEREEQLIKA-KEKLENDIAEIMKMSGDNSS 896
Query: 498 -LNRAKSELNRLQQEETQLEQSIQAGRVQLETIIKSLKSTQDEINQARSKLSQLH-ESRQ 555
L + EL +++ +L+ + + KS++ + Q++ + ++ H E ++
Sbjct: 897 QLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKK 956
Query: 556 EAHRSLEQYDQVLDGAH 572
E R L ++ ++ +H
Sbjct: 957 ELERKLSDLEKKMETSH 973
Score = 47.8 bits (112), Expect = 4e-05
Identities = 47/198 (23%), Positives = 93/198 (46%), Gaps = 16/198 (8%)
Query: 384 KELDDISQEIAQLQREKYSLEQDIREK-EEAIRQKTSEVQELQNDLDRETSSLQELEAQK 442
KE++ + ++ ++ +EK + + IR K ++A Q E+++ N L ++ELE +
Sbjct: 644 KEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQ 703
Query: 443 QDAQDRLDEMD----QQKA---KLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLKSQE 495
++ +D Q KA KL D L +R+ + + L+ Q+++ E +K E
Sbjct: 704 AKCNEQTKVIDNFTSQLKATEEKLLD-LDALRKASSEGKSEMKKLRQQLEAAEKQIKHLE 762
Query: 496 DDLN----RAKSELNRLQQEE---TQLEQSIQAGRVQLETIIKSLKSTQDEINQARSKLS 548
+ N +A S LQ E T L++++ ET+ K L+ +++ +A +
Sbjct: 763 IEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAV 822
Query: 549 QLHESRQEAHRSLEQYDQ 566
+ S QE L Q ++
Sbjct: 823 SVQRSMQETVNKLHQKEE 840
Score = 46.6 bits (109), Expect = 1e-04
Identities = 47/200 (23%), Positives = 97/200 (48%), Gaps = 25/200 (12%)
Query: 379 EFTGVKELDDISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDL----DRETSS 434
+ +G L + +E Q E+ E+D+ E A + TS V E++ +L D
Sbjct: 346 KISGTTALQEALKE-KQQHIEQLLAERDLERAEVA--KATSHVGEIEQELALARDGHDQH 402
Query: 435 LQELEAQKQDAQDRLDEMDQQKAKLRDMLSDVRQKCQD-------ETQMISSLKTQIQSQ 487
+ ELEA+ + ++ D++K +L + L + ++K +D E+ L+ S+
Sbjct: 403 VLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLEVATVSE 462
Query: 488 ESDLKSQEDDLNRAKSELNRLQQEETQLEQSIQAGRVQLE-TIIKSLKSTQDEINQARS- 545
+S + E DL E+ L++ +LE + AG V + ++++ + S Q+++ R+
Sbjct: 463 KSRIMELEKDLALRVQEVAELRR---RLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTD 519
Query: 546 ---KLSQLHE---SRQEAHR 559
+++ L E +R+E H+
Sbjct: 520 HQREITSLKEHFGAREETHQ 539
Score = 41.6 bits (96), Expect = 0.003
Identities = 36/188 (19%), Positives = 86/188 (45%), Gaps = 7/188 (3%)
Query: 383 VKELDDISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEAQK 442
++EL+++ ++ A + + E ++ E+ ++KT + L++ EL+ K
Sbjct: 1023 LQELEELRKQ-ADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLK 1081
Query: 443 QDAQDRLDEMDQQKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLKSQEDDLNRAK 502
++ ++E+++ K ++L+ QK ++ + I +LK + L + +++ +
Sbjct: 1082 ENNLKNVEELNKSK----ELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLA 1137
Query: 503 SELNRLQQEETQLEQSIQAGRVQLETIIKSLKSTQDE-INQARSKLSQLHESRQEAHRSL 561
EL R + E T Q ++ R L + +K + + I A + + L +S L
Sbjct: 1138 EELGRSRDEVTS-HQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALL 1196
Query: 562 EQYDQVLD 569
+ D L+
Sbjct: 1197 TEKDAELE 1204
Score = 37.7 bits (86), Expect = 0.046
Identities = 36/200 (18%), Positives = 85/200 (42%), Gaps = 5/200 (2%)
Query: 382 GVKELDDISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEAQ 441
G E+ +S++ ++ EK + +R +E A ++ E + D+D S LQE+ +
Sbjct: 453 GDLEVATVSEKSRIMELEK---DLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSL 509
Query: 442 KQDAQDRLDEMDQQKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLKSQEDDLNRA 501
++ + + ++ L++ + Q E + + + ++ + LKS+ + N+
Sbjct: 510 QEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKE 569
Query: 502 KSELNRLQQE--ETQLEQSIQAGRVQLETIIKSLKSTQDEINQARSKLSQLHESRQEAHR 559
S++ L + ET + QA + K L + E + ++++ ++ Q
Sbjct: 570 NSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIE 629
Query: 560 SLEQYDQVLDGAHGASLTDL 579
+L+ AH + L
Sbjct: 630 NLQNQQDSERAAHAKEMEAL 649
Score = 37.0 bits (84), Expect = 0.079
Identities = 39/180 (21%), Positives = 84/180 (46%), Gaps = 15/180 (8%)
Query: 403 LEQDIREKEEAIRQKTSEVQ---ELQNDLDR-ETSSLQELEAQKQDAQDRLDEMDQQKAK 458
+EQ +EK E + Q +LQN+LD + ++L+ +E + +++ L +Q+ +
Sbjct: 1049 MEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVE-ELNKSKELLTVENQKMEE 1107
Query: 459 LRDMLSDVRQKCQDETQMISSLKTQIQSQESDLKSQEDDLNRAKSEL---NRLQQEETQL 515
R + ++Q ++Q +S+L QE ++K E +L R++ E+ +L++E + L
Sbjct: 1108 FRKEIETLKQAAAQKSQQLSAL------QEENVKLAE-ELGRSRDEVTSHQKLEEERSVL 1160
Query: 516 EQSIQAGRVQLETIIKSLKSTQDEINQARSKLSQLHESRQEAHRSLEQYDQVLDGAHGAS 575
+ + + IK + + ++ S S L + L VL G + ++
Sbjct: 1161 NNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGENASA 1220
>gi|4506751 restin isoform a [Homo sapiens]
Length = 1427
Score = 66.6 bits (161), Expect = 9e-11
Identities = 36/180 (20%), Positives = 95/180 (52%), Gaps = 6/180 (3%)
Query: 384 KELDDISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEAQKQ 443
KEL + ++ A+ E S+++ ++E + QK + L +DL++ +L ++EA+ +
Sbjct: 840 KELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFR 899
Query: 444 DAQDRLDEMDQQKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLKSQEDDLNRAKS 503
+ +R +++ + K KL + ++++ + D + ++ + +++ +E D++ + L +A
Sbjct: 900 EKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANE 959
Query: 504 ELNRLQQEETQLEQSIQAGRVQLETIIKSLKSTQDEINQARSKLSQLHESRQEAHRSLEQ 563
+ LQ+ + +++A + Q E + K ++E + KLS L + + +H ++
Sbjct: 960 NASFLQKSIE--DMTVKAEQSQQE----AAKKHEEEKKELERKLSDLEKKMETSHNQCQE 1013
Score = 50.8 bits (120), Expect = 5e-06
Identities = 53/248 (21%), Positives = 111/248 (44%), Gaps = 17/248 (6%)
Query: 379 EFTGVKELDDISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDL----DRETSS 434
+ +G L + +E Q E+ E+D+ E A + TS V E++ +L D
Sbjct: 346 KISGTTALQEALKE-KQQHIEQLLAERDLERAEVA--KATSHVGEIEQELALARDGHDQH 402
Query: 435 LQELEAQKQDAQDRLDEMDQQKAKLRDMLSDVRQKCQD-------ETQMISSLKTQIQSQ 487
+ ELEA+ + ++ D++K +L + L + ++K +D E+ L+TQ + +
Sbjct: 403 VLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLETQTKLE 462
Query: 488 ESDLKSQEDDLNRAKSELNRLQQEETQLEQSIQAGRVQLETIIKSLKSTQDEINQARSKL 547
+ +K E L K++ ++LQ+E + + + ++ + K L E+ + R +L
Sbjct: 463 HARIKELEQSLLFEKTKADKLQRELEDTRVATVSEKSRIMELEKDLALRVQEVAELRRRL 522
Query: 548 SQLHESRQEAHRSLEQYDQVLDGAHGASLTDLANLSEGVSLAERGSFGAMDDPFKNKALL 607
+ ++ + SL ++ +T + E SL E FGA ++ + +
Sbjct: 523 -ESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEH--FGAREETHQKEIKA 579
Query: 608 FSNNTQEL 615
T++L
Sbjct: 580 LYTATEKL 587
Score = 49.7 bits (117), Expect = 1e-05
Identities = 35/197 (17%), Positives = 95/197 (48%), Gaps = 17/197 (8%)
Query: 385 ELDDISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEAQKQD 444
+L ++ + ++++ + K +LE++++ +E + + E +Q + + L + E Q
Sbjct: 820 KLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQ--- 876
Query: 445 AQDRLDEMDQQKAKLRDMLSDV----RQKCQDETQMISSLKTQIQSQESDLKSQEDD--- 497
+ + KLR+ L+D+ R+K + E Q+I + K ++++ +++ D
Sbjct: 877 ----FNMLSSDLEKLRENLADMEAKFREKDEREEQLIKA-KEKLENDIAEIMKMSGDNSS 931
Query: 498 -LNRAKSELNRLQQEETQLEQSIQAGRVQLETIIKSLKSTQDEINQARSKLSQLH-ESRQ 555
L + EL +++ +L+ + + KS++ + Q++ + ++ H E ++
Sbjct: 932 QLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKK 991
Query: 556 EAHRSLEQYDQVLDGAH 572
E R L ++ ++ +H
Sbjct: 992 ELERKLSDLEKKMETSH 1008
Score = 47.8 bits (112), Expect = 4e-05
Identities = 47/198 (23%), Positives = 93/198 (46%), Gaps = 16/198 (8%)
Query: 384 KELDDISQEIAQLQREKYSLEQDIREK-EEAIRQKTSEVQELQNDLDRETSSLQELEAQK 442
KE++ + ++ ++ +EK + + IR K ++A Q E+++ N L ++ELE +
Sbjct: 679 KEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQ 738
Query: 443 QDAQDRLDEMD----QQKA---KLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLKSQE 495
++ +D Q KA KL D L +R+ + + L+ Q+++ E +K E
Sbjct: 739 AKCNEQTKVIDNFTSQLKATEEKLLD-LDALRKASSEGKSEMKKLRQQLEAAEKQIKHLE 797
Query: 496 DDLN----RAKSELNRLQQEE---TQLEQSIQAGRVQLETIIKSLKSTQDEINQARSKLS 548
+ N +A S LQ E T L++++ ET+ K L+ +++ +A +
Sbjct: 798 IEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAV 857
Query: 549 QLHESRQEAHRSLEQYDQ 566
+ S QE L Q ++
Sbjct: 858 SVQRSMQETVNKLHQKEE 875
Score = 41.6 bits (96), Expect = 0.003
Identities = 36/188 (19%), Positives = 86/188 (45%), Gaps = 7/188 (3%)
Query: 383 VKELDDISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEAQK 442
++EL+++ ++ A + + E ++ E+ ++KT + L++ EL+ K
Sbjct: 1058 LQELEELRKQ-ADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLK 1116
Query: 443 QDAQDRLDEMDQQKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLKSQEDDLNRAK 502
++ ++E+++ K ++L+ QK ++ + I +LK + L + +++ +
Sbjct: 1117 ENNLKNVEELNKSK----ELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLA 1172
Query: 503 SELNRLQQEETQLEQSIQAGRVQLETIIKSLKSTQDE-INQARSKLSQLHESRQEAHRSL 561
EL R + E T Q ++ R L + +K + + I A + + L +S L
Sbjct: 1173 EELGRSRDEVTS-HQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALL 1231
Query: 562 EQYDQVLD 569
+ D L+
Sbjct: 1232 TEKDAELE 1239
Score = 39.7 bits (91), Expect = 0.012
Identities = 37/204 (18%), Positives = 83/204 (40%), Gaps = 11/204 (5%)
Query: 387 DDISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQN---------DLDRETSSLQE 437
D + +E+ + S + I E E+ + + EV EL+ D+D S LQE
Sbjct: 481 DKLQRELEDTRVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQE 540
Query: 438 LEAQKQDAQDRLDEMDQQKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLKSQEDD 497
+ + ++ + + ++ L++ + Q E + + + ++ + LKS+ +
Sbjct: 541 ISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEH 600
Query: 498 LNRAKSELNRLQQE--ETQLEQSIQAGRVQLETIIKSLKSTQDEINQARSKLSQLHESRQ 555
N+ S++ L + ET + QA + K L + E + ++++ ++ Q
Sbjct: 601 ANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQ 660
Query: 556 EAHRSLEQYDQVLDGAHGASLTDL 579
+L+ AH + L
Sbjct: 661 HEIENLQNQQDSERAAHAKEMEAL 684
Score = 37.0 bits (84), Expect = 0.079
Identities = 39/180 (21%), Positives = 84/180 (46%), Gaps = 15/180 (8%)
Query: 403 LEQDIREKEEAIRQKTSEVQ---ELQNDLDR-ETSSLQELEAQKQDAQDRLDEMDQQKAK 458
+EQ +EK E + Q +LQN+LD + ++L+ +E + +++ L +Q+ +
Sbjct: 1084 MEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVE-ELNKSKELLTVENQKMEE 1142
Query: 459 LRDMLSDVRQKCQDETQMISSLKTQIQSQESDLKSQEDDLNRAKSEL---NRLQQEETQL 515
R + ++Q ++Q +S+L QE ++K E +L R++ E+ +L++E + L
Sbjct: 1143 FRKEIETLKQAAAQKSQQLSAL------QEENVKLAE-ELGRSRDEVTSHQKLEEERSVL 1195
Query: 516 EQSIQAGRVQLETIIKSLKSTQDEINQARSKLSQLHESRQEAHRSLEQYDQVLDGAHGAS 575
+ + + IK + + ++ S S L + L VL G + ++
Sbjct: 1196 NNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGENASA 1255
>gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]
Length = 2003
Score = 66.2 bits (160), Expect = 1e-10
Identities = 48/205 (23%), Positives = 101/205 (49%), Gaps = 9/205 (4%)
Query: 391 QEIAQLQREKYSLEQDIREKEEAIRQKTS---EVQELQNDLDRETSSLQELEAQKQDAQD 447
+++ L + + E I + E+ +R++ E+++L+ LD E+S LQE Q + Q
Sbjct: 1045 EKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQE---QMVEQQQ 1101
Query: 448 RLDEMDQQKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLKSQEDDLNRAKSELNR 507
R +E+ Q + + L + +DE + L ++ ++ L ++DL + +
Sbjct: 1102 RAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTK 1161
Query: 508 LQQEETQLEQSIQAGRVQLETIIKSLKSTQDEINQARSKLSQLHESRQEAHRSLEQYDQV 567
+++ L + ++A R +LE + S + Q+ ++ ++++L ++ +E R E Q
Sbjct: 1162 AEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQE 1221
Query: 568 LDGAHGASLTDLANLSEGVSLAERG 592
L HG +L +LA E + A RG
Sbjct: 1222 LRQRHGQALGELA---EQLEQARRG 1243
Score = 52.0 bits (123), Expect = 2e-06
Identities = 40/189 (21%), Positives = 91/189 (48%), Gaps = 14/189 (7%)
Query: 395 QLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEAQKQDAQDRLDEMDQ 454
Q+Q EK L+Q I+E E + + Q+LQ + + +++ E +D+ ++ +
Sbjct: 965 QMQTEKKRLQQHIQELEAHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSK 1024
Query: 455 QKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLKSQEDDL---NRAKSELNRLQQ- 510
++ L D L++ + +E + + SL E+ + ED L + + EL +L++
Sbjct: 1025 ERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRR 1084
Query: 511 ---EETQLEQSIQAGRVQLETIIKSLKSTQDEINQARSKL-------SQLHESRQEAHRS 560
E ++L++ + + + E + L ++E+ A ++ +QL +S +EA +
Sbjct: 1085 LDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAA 1144
Query: 561 LEQYDQVLD 569
L + + L+
Sbjct: 1145 LAEAQEDLE 1153
Score = 48.9 bits (115), Expect = 2e-05
Identities = 53/301 (17%), Positives = 127/301 (42%), Gaps = 25/301 (8%)
Query: 312 LLAHIWALADTRQTGKLSKDQFALAMYFIQQKVSKGIDPPQVLSPDMVPPSERGTPGPDS 371
L A + +L RQ G+ + + L + +Q + G + + +R ++
Sbjct: 1261 LRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDG----ERARAEAAEKLQRAQAELEN 1316
Query: 372 -SGSLGSGEFTGVKELDDISQEIAQLQREKYSLEQDIREK---EEAIRQKTSEVQELQND 427
SG+L E ++ ++S AQL + L+++ R K +R +E L+
Sbjct: 1317 VSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQ 1376
Query: 428 LDRETSSLQELEAQKQDAQDRLDEM--------------DQQKAKLRDMLSDVRQKCQDE 473
L+ E ++ + + Q AQ +L E ++ + + + Q+ ++
Sbjct: 1377 LEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEK 1436
Query: 474 TQMISSLKTQIQSQESDLKSQEDDLNRAKSELNRLQQEETQLEQSIQAGRVQLETIIKSL 533
T+ + L+ + + +L DL + + ++ L++++ + +Q + + + ++
Sbjct: 1437 TETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEER 1496
Query: 534 KSTQDEINQARSK---LSQLHESRQEAHRSLEQYDQVLDGAHGASLTDLANLSEGVSLAE 590
+ + E + ++ L++ E QEA LE+ ++ L A L+ ++ + V E
Sbjct: 1497 ERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHELE 1556
Query: 591 R 591
R
Sbjct: 1557 R 1557
Score = 48.9 bits (115), Expect = 2e-05
Identities = 38/201 (18%), Positives = 89/201 (44%), Gaps = 9/201 (4%)
Query: 384 KELDDISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEAQKQ 443
+EL ++++ +R + + EEA R+ E + L L +T ++ LE ++
Sbjct: 1389 RELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRR 1448
Query: 444 DAQDRLDEMDQQKAKLRDMLSDVRQKCQDETQMISSLKTQI-----QSQESDLKSQEDDL 498
Q LD+ + R ++S + +K + Q+++ K + + + ++ + +E +
Sbjct: 1449 RLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREA 1508
Query: 499 NRAKSELNRLQQEE---TQLEQSIQAGRVQLETIIKSLKSTQDEINQARSKLSQLHESRQ 555
RA S L++E+ +LE+ +A R +LE ++ S +++ ++
Sbjct: 1509 -RALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAAN 1567
Query: 556 EAHRSLEQYDQVLDGAHGASL 576
+ + + + L A A L
Sbjct: 1568 DLRAQVTELEDELTAAEDAKL 1588
Score = 47.4 bits (111), Expect = 6e-05
Identities = 43/203 (21%), Positives = 87/203 (42%), Gaps = 11/203 (5%)
Query: 379 EFTGVKELDDIS-QEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQE 437
E V+EL S +E+ +LQ LE++ E +R + E + R + QE
Sbjct: 885 ELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEAEETRGRLAARKQE 944
Query: 438 LEAQKQDAQDRLDE-------MDQQKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQESD 490
LE + + R+ E M +K +L+ + ++ + E L+ + + E+
Sbjct: 945 LELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGARQKLQLEKVTTEAK 1004
Query: 491 LKSQEDDLNRAKSELNRLQQEETQLEQSI---QAGRVQLETIIKSLKSTQDEINQARSKL 547
+K E+DL + + ++L +E LE + + + E +KSL + + + +
Sbjct: 1005 MKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADM 1064
Query: 548 SQLHESRQEAHRSLEQYDQVLDG 570
++ + LE+ + LDG
Sbjct: 1065 EDRLRKEEKGRQELEKLKRRLDG 1087
Score = 46.6 bits (109), Expect = 1e-04
Identities = 51/212 (24%), Positives = 95/212 (44%), Gaps = 20/212 (9%)
Query: 374 SLGSGEFTGVKELDDISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETS 433
S G G+ VK+L + ++ +L RE ++ R E I + E ++ L+ E
Sbjct: 1660 SAGQGKEEAVKQLRKMQAQMKELWRE----VEETRTSREEIFSQNRESEKRLKGLEAEVL 1715
Query: 434 SLQEL-----EAQKQDAQDRLDEMDQQKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQE 488
LQE A++Q QDR DEM + A + + ++ + + L+ +++ ++
Sbjct: 1716 RLQEELAASDRARRQAQQDR-DEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQ 1774
Query: 489 SDLKSQEDDLNRAKSELNRLQQE---ETQLEQSIQAGRVQLETIIKSLK---STQDEINQ 542
S+ + D + ++ L E E ++GR QLE I+ L+ +D +
Sbjct: 1775 SNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGAR 1834
Query: 543 ARSK--LSQLHESRQEAHRSLEQ--YDQVLDG 570
AR K ++ L +A LEQ +++L G
Sbjct: 1835 ARHKMTIAALESKLAQAEEQLEQETRERILSG 1866
Score = 46.2 bits (108), Expect = 1e-04
Identities = 46/224 (20%), Positives = 103/224 (45%), Gaps = 18/224 (8%)
Query: 385 ELDDISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEAQKQD 444
E ++ +++ + Q+ L + KEE ++ + ++ + SL+E +A +
Sbjct: 1088 ESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAE 1147
Query: 445 AQDRLD-------EMDQQKAKLRDMLSDVRQKCQ---DETQMISSLKTQIQSQESDL-KS 493
AQ+ L+ + ++Q+ L + L +R + + D T L+++ + + ++L K+
Sbjct: 1148 AQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKT 1207
Query: 494 QEDDLNRAKSELNRLQQEETQ----LEQSIQAGRVQLETIIKSLKSTQDEINQARSKLSQ 549
E++ ++ + L+Q Q L + ++ R K+ + + E+++ R++LS
Sbjct: 1208 LEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSS 1267
Query: 550 LHESRQEA---HRSLEQYDQVLDGAHGASLTDLANLSEGVSLAE 590
L +RQE R LE Q + G G A +E + A+
Sbjct: 1268 LQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQ 1311
Score = 42.7 bits (99), Expect = 0.001
Identities = 44/219 (20%), Positives = 110/219 (50%), Gaps = 29/219 (13%)
Query: 370 DSSGSLGSGEFT---GVKELDDISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQE--- 423
+ +G+L +GE +E + ++Q +A+ LE+ R ++ + T ++++
Sbjct: 1407 EEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQ 1466
Query: 424 LQNDLDRETSSLQELEAQKQDAQDR-LDEMDQQKAKLRDMLS---DVRQKCQDETQMISS 479
L + L+++ +L A+++ A R ++E ++ +A+ R+ + + + ++E +
Sbjct: 1467 LVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREE 1526
Query: 480 LKTQIQSQESDLK---SQEDDLNRAKSELNR-----------LQQEETQLEQSIQA---G 522
L+ Q ++ ++L+ S +DD+ ++ EL R L+ + T+LE + A
Sbjct: 1527 LERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDA 1586
Query: 523 RVQLETIIKSLKSTQDEINQARSKLSQLHESRQEAHRSL 561
+++LE +++LK+ + Q R + + E R++ + L
Sbjct: 1587 KLRLEVTVQALKTQHERDLQGRDEAGE--ERRRQLAKQL 1623
Score = 37.0 bits (84), Expect = 0.079
Identities = 53/247 (21%), Positives = 106/247 (42%), Gaps = 46/247 (18%)
Query: 383 VKELDD--ISQEIAQLQRE------KYSLEQDIREKEEA----IRQKTSEVQELQNDLDR 430
V EL+D + E A+L+ E K E+D++ ++EA RQ ++++ + + D
Sbjct: 1573 VTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDE 1632
Query: 431 ETSSLQELEAQKQDAQDRLDEMDQQKA--------------KLRDMLSDVRQKCQDETQM 476
E A ++ + L+E+ Q A K++ + ++ ++ ++
Sbjct: 1633 ERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTS 1692
Query: 477 ISSLKTQIQSQESDLKSQEDDLNRAKSEL-------NRLQQEETQLEQSIQAGRVQLETI 529
+ +Q + E LK E ++ R + EL + QQ+ ++ + G + I
Sbjct: 1693 REEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAI 1752
Query: 530 IKSLKSTQDEINQARSKLSQLHESRQEAHRSLEQYDQVLDGAHGASLTDLANLSEGVSLA 589
+ +E Q +L QL E +E + E +L+ + L + +L+ +S A
Sbjct: 1753 L-------EEKRQLEGRLGQLEEELEEEQSNSE----LLNDRYRKLLLQVESLTTELS-A 1800
Query: 590 ERGSFGA 596
ER SF A
Sbjct: 1801 ER-SFSA 1806
Score = 33.5 bits (75), Expect = 0.87
Identities = 21/132 (15%), Positives = 65/132 (49%), Gaps = 3/132 (2%)
Query: 364 RGTPGPDSSGSLGSGEFTGV---KELDDISQEIAQLQREKYSLEQDIREKEEAIRQKTSE 420
RG G + +G+ + T +L +++ Q RE+ + +R E+ +++ +
Sbjct: 1823 RGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQ 1882
Query: 421 VQELQNDLDRETSSLQELEAQKQDAQDRLDEMDQQKAKLRDMLSDVRQKCQDETQMISSL 480
V+E + D+ L++ + + + +L+E +++ ++ + ++++ +D T+ S+
Sbjct: 1883 VEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDVTESAESM 1942
Query: 481 KTQIQSQESDLK 492
++ + + L+
Sbjct: 1943 NREVTTLRNRLR 1954
>gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]
Length = 1995
Score = 66.2 bits (160), Expect = 1e-10
Identities = 48/205 (23%), Positives = 101/205 (49%), Gaps = 9/205 (4%)
Query: 391 QEIAQLQREKYSLEQDIREKEEAIRQKTS---EVQELQNDLDRETSSLQELEAQKQDAQD 447
+++ L + + E I + E+ +R++ E+++L+ LD E+S LQE Q + Q
Sbjct: 1037 EKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQE---QMVEQQQ 1093
Query: 448 RLDEMDQQKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLKSQEDDLNRAKSELNR 507
R +E+ Q + + L + +DE + L ++ ++ L ++DL + +
Sbjct: 1094 RAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTK 1153
Query: 508 LQQEETQLEQSIQAGRVQLETIIKSLKSTQDEINQARSKLSQLHESRQEAHRSLEQYDQV 567
+++ L + ++A R +LE + S + Q+ ++ ++++L ++ +E R E Q
Sbjct: 1154 AEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQE 1213
Query: 568 LDGAHGASLTDLANLSEGVSLAERG 592
L HG +L +LA E + A RG
Sbjct: 1214 LRQRHGQALGELA---EQLEQARRG 1235
Score = 52.0 bits (123), Expect = 2e-06
Identities = 40/189 (21%), Positives = 91/189 (48%), Gaps = 14/189 (7%)
Query: 395 QLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEAQKQDAQDRLDEMDQ 454
Q+Q EK L+Q I+E E + + Q+LQ + + +++ E +D+ ++ +
Sbjct: 957 QMQTEKKRLQQHIQELEAHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSK 1016
Query: 455 QKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLKSQEDDL---NRAKSELNRLQQ- 510
++ L D L++ + +E + + SL E+ + ED L + + EL +L++
Sbjct: 1017 ERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRR 1076
Query: 511 ---EETQLEQSIQAGRVQLETIIKSLKSTQDEINQARSKL-------SQLHESRQEAHRS 560
E ++L++ + + + E + L ++E+ A ++ +QL +S +EA +
Sbjct: 1077 LDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAA 1136
Query: 561 LEQYDQVLD 569
L + + L+
Sbjct: 1137 LAEAQEDLE 1145
Score = 48.9 bits (115), Expect = 2e-05
Identities = 53/301 (17%), Positives = 127/301 (42%), Gaps = 25/301 (8%)
Query: 312 LLAHIWALADTRQTGKLSKDQFALAMYFIQQKVSKGIDPPQVLSPDMVPPSERGTPGPDS 371
L A + +L RQ G+ + + L + +Q + G + + +R ++
Sbjct: 1253 LRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDG----ERARAEAAEKLQRAQAELEN 1308
Query: 372 -SGSLGSGEFTGVKELDDISQEIAQLQREKYSLEQDIREK---EEAIRQKTSEVQELQND 427
SG+L E ++ ++S AQL + L+++ R K +R +E L+
Sbjct: 1309 VSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQ 1368
Query: 428 LDRETSSLQELEAQKQDAQDRLDEM--------------DQQKAKLRDMLSDVRQKCQDE 473
L+ E ++ + + Q AQ +L E ++ + + + Q+ ++
Sbjct: 1369 LEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEK 1428
Query: 474 TQMISSLKTQIQSQESDLKSQEDDLNRAKSELNRLQQEETQLEQSIQAGRVQLETIIKSL 533
T+ + L+ + + +L DL + + ++ L++++ + +Q + + + ++
Sbjct: 1429 TETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEER 1488
Query: 534 KSTQDEINQARSK---LSQLHESRQEAHRSLEQYDQVLDGAHGASLTDLANLSEGVSLAE 590
+ + E + ++ L++ E QEA LE+ ++ L A L+ ++ + V E
Sbjct: 1489 ERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHELE 1548
Query: 591 R 591
R
Sbjct: 1549 R 1549
Score = 48.9 bits (115), Expect = 2e-05
Identities = 38/201 (18%), Positives = 89/201 (44%), Gaps = 9/201 (4%)
Query: 384 KELDDISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEAQKQ 443
+EL ++++ +R + + EEA R+ E + L L +T ++ LE ++
Sbjct: 1381 RELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRR 1440
Query: 444 DAQDRLDEMDQQKAKLRDMLSDVRQKCQDETQMISSLKTQI-----QSQESDLKSQEDDL 498
Q LD+ + R ++S + +K + Q+++ K + + + ++ + +E +
Sbjct: 1441 RLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREA 1500
Query: 499 NRAKSELNRLQQEE---TQLEQSIQAGRVQLETIIKSLKSTQDEINQARSKLSQLHESRQ 555
RA S L++E+ +LE+ +A R +LE ++ S +++ ++
Sbjct: 1501 -RALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAAN 1559
Query: 556 EAHRSLEQYDQVLDGAHGASL 576
+ + + + L A A L
Sbjct: 1560 DLRAQVTELEDELTAAEDAKL 1580
Score = 47.4 bits (111), Expect = 6e-05
Identities = 43/203 (21%), Positives = 87/203 (42%), Gaps = 11/203 (5%)
Query: 379 EFTGVKELDDIS-QEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQE 437
E V+EL S +E+ +LQ LE++ E +R + E + R + QE
Sbjct: 877 ELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEAEETRGRLAARKQE 936
Query: 438 LEAQKQDAQDRLDE-------MDQQKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQESD 490
LE + + R+ E M +K +L+ + ++ + E L+ + + E+
Sbjct: 937 LELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGARQKLQLEKVTTEAK 996
Query: 491 LKSQEDDLNRAKSELNRLQQEETQLEQSI---QAGRVQLETIIKSLKSTQDEINQARSKL 547
+K E+DL + + ++L +E LE + + + E +KSL + + + +
Sbjct: 997 MKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADM 1056
Query: 548 SQLHESRQEAHRSLEQYDQVLDG 570
++ + LE+ + LDG
Sbjct: 1057 EDRLRKEEKGRQELEKLKRRLDG 1079
Score = 46.6 bits (109), Expect = 1e-04
Identities = 51/212 (24%), Positives = 95/212 (44%), Gaps = 20/212 (9%)
Query: 374 SLGSGEFTGVKELDDISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETS 433
S G G+ VK+L + ++ +L RE ++ R E I + E ++ L+ E
Sbjct: 1652 SAGQGKEEAVKQLRKMQAQMKELWRE----VEETRTSREEIFSQNRESEKRLKGLEAEVL 1707
Query: 434 SLQEL-----EAQKQDAQDRLDEMDQQKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQE 488
LQE A++Q QDR DEM + A + + ++ + + L+ +++ ++
Sbjct: 1708 RLQEELAASDRARRQAQQDR-DEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQ 1766
Query: 489 SDLKSQEDDLNRAKSELNRLQQE---ETQLEQSIQAGRVQLETIIKSLK---STQDEINQ 542
S+ + D + ++ L E E ++GR QLE I+ L+ +D +
Sbjct: 1767 SNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGAR 1826
Query: 543 ARSK--LSQLHESRQEAHRSLEQ--YDQVLDG 570
AR K ++ L +A LEQ +++L G
Sbjct: 1827 ARHKMTIAALESKLAQAEEQLEQETRERILSG 1858
Score = 46.2 bits (108), Expect = 1e-04
Identities = 46/224 (20%), Positives = 103/224 (45%), Gaps = 18/224 (8%)
Query: 385 ELDDISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEAQKQD 444
E ++ +++ + Q+ L + KEE ++ + ++ + SL+E +A +
Sbjct: 1080 ESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAE 1139
Query: 445 AQDRLD-------EMDQQKAKLRDMLSDVRQKCQ---DETQMISSLKTQIQSQESDL-KS 493
AQ+ L+ + ++Q+ L + L +R + + D T L+++ + + ++L K+
Sbjct: 1140 AQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKT 1199
Query: 494 QEDDLNRAKSELNRLQQEETQ----LEQSIQAGRVQLETIIKSLKSTQDEINQARSKLSQ 549
E++ ++ + L+Q Q L + ++ R K+ + + E+++ R++LS
Sbjct: 1200 LEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSS 1259
Query: 550 LHESRQEA---HRSLEQYDQVLDGAHGASLTDLANLSEGVSLAE 590
L +RQE R LE Q + G G A +E + A+
Sbjct: 1260 LQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQ 1303
Score = 42.7 bits (99), Expect = 0.001
Identities = 44/219 (20%), Positives = 110/219 (50%), Gaps = 29/219 (13%)
Query: 370 DSSGSLGSGEFT---GVKELDDISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQE--- 423
+ +G+L +GE +E + ++Q +A+ LE+ R ++ + T ++++
Sbjct: 1399 EEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQ 1458
Query: 424 LQNDLDRETSSLQELEAQKQDAQDR-LDEMDQQKAKLRDMLS---DVRQKCQDETQMISS 479
L + L+++ +L A+++ A R ++E ++ +A+ R+ + + + ++E +
Sbjct: 1459 LVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREE 1518
Query: 480 LKTQIQSQESDLK---SQEDDLNRAKSELNR-----------LQQEETQLEQSIQA---G 522
L+ Q ++ ++L+ S +DD+ ++ EL R L+ + T+LE + A
Sbjct: 1519 LERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDA 1578
Query: 523 RVQLETIIKSLKSTQDEINQARSKLSQLHESRQEAHRSL 561
+++LE +++LK+ + Q R + + E R++ + L
Sbjct: 1579 KLRLEVTVQALKTQHERDLQGRDEAGE--ERRRQLAKQL 1615
Score = 37.0 bits (84), Expect = 0.079
Identities = 53/247 (21%), Positives = 106/247 (42%), Gaps = 46/247 (18%)
Query: 383 VKELDD--ISQEIAQLQRE------KYSLEQDIREKEEA----IRQKTSEVQELQNDLDR 430
V EL+D + E A+L+ E K E+D++ ++EA RQ ++++ + + D
Sbjct: 1565 VTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDE 1624
Query: 431 ETSSLQELEAQKQDAQDRLDEMDQQKA--------------KLRDMLSDVRQKCQDETQM 476
E A ++ + L+E+ Q A K++ + ++ ++ ++
Sbjct: 1625 ERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTS 1684
Query: 477 ISSLKTQIQSQESDLKSQEDDLNRAKSEL-------NRLQQEETQLEQSIQAGRVQLETI 529
+ +Q + E LK E ++ R + EL + QQ+ ++ + G + I
Sbjct: 1685 REEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAI 1744
Query: 530 IKSLKSTQDEINQARSKLSQLHESRQEAHRSLEQYDQVLDGAHGASLTDLANLSEGVSLA 589
+ +E Q +L QL E +E + E +L+ + L + +L+ +S A
Sbjct: 1745 L-------EEKRQLEGRLGQLEEELEEEQSNSE----LLNDRYRKLLLQVESLTTELS-A 1792
Query: 590 ERGSFGA 596
ER SF A
Sbjct: 1793 ER-SFSA 1798
Score = 33.5 bits (75), Expect = 0.87
Identities = 21/132 (15%), Positives = 65/132 (49%), Gaps = 3/132 (2%)
Query: 364 RGTPGPDSSGSLGSGEFTGV---KELDDISQEIAQLQREKYSLEQDIREKEEAIRQKTSE 420
RG G + +G+ + T +L +++ Q RE+ + +R E+ +++ +
Sbjct: 1815 RGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQ 1874
Query: 421 VQELQNDLDRETSSLQELEAQKQDAQDRLDEMDQQKAKLRDMLSDVRQKCQDETQMISSL 480
V+E + D+ L++ + + + +L+E +++ ++ + ++++ +D T+ S+
Sbjct: 1875 VEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDVTESAESM 1934
Query: 481 KTQIQSQESDLK 492
++ + + L+
Sbjct: 1935 NREVTTLRNRLR 1946
>gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]
Length = 2036
Score = 66.2 bits (160), Expect = 1e-10
Identities = 48/205 (23%), Positives = 101/205 (49%), Gaps = 9/205 (4%)
Query: 391 QEIAQLQREKYSLEQDIREKEEAIRQKTS---EVQELQNDLDRETSSLQELEAQKQDAQD 447
+++ L + + E I + E+ +R++ E+++L+ LD E+S LQE Q + Q
Sbjct: 1078 EKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQE---QMVEQQQ 1134
Query: 448 RLDEMDQQKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLKSQEDDLNRAKSELNR 507
R +E+ Q + + L + +DE + L ++ ++ L ++DL + +
Sbjct: 1135 RAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTK 1194
Query: 508 LQQEETQLEQSIQAGRVQLETIIKSLKSTQDEINQARSKLSQLHESRQEAHRSLEQYDQV 567
+++ L + ++A R +LE + S + Q+ ++ ++++L ++ +E R E Q
Sbjct: 1195 AEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQE 1254
Query: 568 LDGAHGASLTDLANLSEGVSLAERG 592
L HG +L +LA E + A RG
Sbjct: 1255 LRQRHGQALGELA---EQLEQARRG 1276
Score = 52.0 bits (123), Expect = 2e-06
Identities = 40/189 (21%), Positives = 91/189 (48%), Gaps = 14/189 (7%)
Query: 395 QLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEAQKQDAQDRLDEMDQ 454
Q+Q EK L+Q I+E E + + Q+LQ + + +++ E +D+ ++ +
Sbjct: 998 QMQTEKKRLQQHIQELEAHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSK 1057
Query: 455 QKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLKSQEDDL---NRAKSELNRLQQ- 510
++ L D L++ + +E + + SL E+ + ED L + + EL +L++
Sbjct: 1058 ERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRR 1117
Query: 511 ---EETQLEQSIQAGRVQLETIIKSLKSTQDEINQARSKL-------SQLHESRQEAHRS 560
E ++L++ + + + E + L ++E+ A ++ +QL +S +EA +
Sbjct: 1118 LDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAA 1177
Query: 561 LEQYDQVLD 569
L + + L+
Sbjct: 1178 LAEAQEDLE 1186
Score = 48.9 bits (115), Expect = 2e-05
Identities = 53/301 (17%), Positives = 127/301 (42%), Gaps = 25/301 (8%)
Query: 312 LLAHIWALADTRQTGKLSKDQFALAMYFIQQKVSKGIDPPQVLSPDMVPPSERGTPGPDS 371
L A + +L RQ G+ + + L + +Q + G + + +R ++
Sbjct: 1294 LRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDG----ERARAEAAEKLQRAQAELEN 1349
Query: 372 -SGSLGSGEFTGVKELDDISQEIAQLQREKYSLEQDIREK---EEAIRQKTSEVQELQND 427
SG+L E ++ ++S AQL + L+++ R K +R +E L+
Sbjct: 1350 VSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQ 1409
Query: 428 LDRETSSLQELEAQKQDAQDRLDEM--------------DQQKAKLRDMLSDVRQKCQDE 473
L+ E ++ + + Q AQ +L E ++ + + + Q+ ++
Sbjct: 1410 LEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEK 1469
Query: 474 TQMISSLKTQIQSQESDLKSQEDDLNRAKSELNRLQQEETQLEQSIQAGRVQLETIIKSL 533
T+ + L+ + + +L DL + + ++ L++++ + +Q + + + ++
Sbjct: 1470 TETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEER 1529
Query: 534 KSTQDEINQARSK---LSQLHESRQEAHRSLEQYDQVLDGAHGASLTDLANLSEGVSLAE 590
+ + E + ++ L++ E QEA LE+ ++ L A L+ ++ + V E
Sbjct: 1530 ERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHELE 1589
Query: 591 R 591
R
Sbjct: 1590 R 1590
Score = 48.9 bits (115), Expect = 2e-05
Identities = 38/201 (18%), Positives = 89/201 (44%), Gaps = 9/201 (4%)
Query: 384 KELDDISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEAQKQ 443
+EL ++++ +R + + EEA R+ E + L L +T ++ LE ++
Sbjct: 1422 RELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRR 1481
Query: 444 DAQDRLDEMDQQKAKLRDMLSDVRQKCQDETQMISSLKTQI-----QSQESDLKSQEDDL 498
Q LD+ + R ++S + +K + Q+++ K + + + ++ + +E +
Sbjct: 1482 RLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREA 1541
Query: 499 NRAKSELNRLQQEE---TQLEQSIQAGRVQLETIIKSLKSTQDEINQARSKLSQLHESRQ 555
RA S L++E+ +LE+ +A R +LE ++ S +++ ++
Sbjct: 1542 -RALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAAN 1600
Query: 556 EAHRSLEQYDQVLDGAHGASL 576
+ + + + L A A L
Sbjct: 1601 DLRAQVTELEDELTAAEDAKL 1621
Score = 47.4 bits (111), Expect = 6e-05
Identities = 43/203 (21%), Positives = 87/203 (42%), Gaps = 11/203 (5%)
Query: 379 EFTGVKELDDIS-QEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQE 437
E V+EL S +E+ +LQ LE++ E +R + E + R + QE
Sbjct: 918 ELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEAEETRGRLAARKQE 977
Query: 438 LEAQKQDAQDRLDE-------MDQQKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQESD 490
LE + + R+ E M +K +L+ + ++ + E L+ + + E+
Sbjct: 978 LELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGARQKLQLEKVTTEAK 1037
Query: 491 LKSQEDDLNRAKSELNRLQQEETQLEQSI---QAGRVQLETIIKSLKSTQDEINQARSKL 547
+K E+DL + + ++L +E LE + + + E +KSL + + + +
Sbjct: 1038 MKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADM 1097
Query: 548 SQLHESRQEAHRSLEQYDQVLDG 570
++ + LE+ + LDG
Sbjct: 1098 EDRLRKEEKGRQELEKLKRRLDG 1120
Score = 46.6 bits (109), Expect = 1e-04
Identities = 51/212 (24%), Positives = 95/212 (44%), Gaps = 20/212 (9%)
Query: 374 SLGSGEFTGVKELDDISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETS 433
S G G+ VK+L + ++ +L RE ++ R E I + E ++ L+ E
Sbjct: 1693 SAGQGKEEAVKQLRKMQAQMKELWRE----VEETRTSREEIFSQNRESEKRLKGLEAEVL 1748
Query: 434 SLQEL-----EAQKQDAQDRLDEMDQQKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQE 488
LQE A++Q QDR DEM + A + + ++ + + L+ +++ ++
Sbjct: 1749 RLQEELAASDRARRQAQQDR-DEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQ 1807
Query: 489 SDLKSQEDDLNRAKSELNRLQQE---ETQLEQSIQAGRVQLETIIKSLK---STQDEINQ 542
S+ + D + ++ L E E ++GR QLE I+ L+ +D +
Sbjct: 1808 SNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGAR 1867
Query: 543 ARSK--LSQLHESRQEAHRSLEQ--YDQVLDG 570
AR K ++ L +A LEQ +++L G
Sbjct: 1868 ARHKMTIAALESKLAQAEEQLEQETRERILSG 1899
Score = 46.2 bits (108), Expect = 1e-04
Identities = 46/224 (20%), Positives = 103/224 (45%), Gaps = 18/224 (8%)
Query: 385 ELDDISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEAQKQD 444
E ++ +++ + Q+ L + KEE ++ + ++ + SL+E +A +
Sbjct: 1121 ESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAE 1180
Query: 445 AQDRLD-------EMDQQKAKLRDMLSDVRQKCQ---DETQMISSLKTQIQSQESDL-KS 493
AQ+ L+ + ++Q+ L + L +R + + D T L+++ + + ++L K+
Sbjct: 1181 AQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKT 1240
Query: 494 QEDDLNRAKSELNRLQQEETQ----LEQSIQAGRVQLETIIKSLKSTQDEINQARSKLSQ 549
E++ ++ + L+Q Q L + ++ R K+ + + E+++ R++LS
Sbjct: 1241 LEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSS 1300
Query: 550 LHESRQEA---HRSLEQYDQVLDGAHGASLTDLANLSEGVSLAE 590
L +RQE R LE Q + G G A +E + A+
Sbjct: 1301 LQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQ 1344
Score = 42.7 bits (99), Expect = 0.001
Identities = 44/219 (20%), Positives = 110/219 (50%), Gaps = 29/219 (13%)
Query: 370 DSSGSLGSGEFT---GVKELDDISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQE--- 423
+ +G+L +GE +E + ++Q +A+ LE+ R ++ + T ++++
Sbjct: 1440 EEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQ 1499
Query: 424 LQNDLDRETSSLQELEAQKQDAQDR-LDEMDQQKAKLRDMLS---DVRQKCQDETQMISS 479
L + L+++ +L A+++ A R ++E ++ +A+ R+ + + + ++E +
Sbjct: 1500 LVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREE 1559
Query: 480 LKTQIQSQESDLK---SQEDDLNRAKSELNR-----------LQQEETQLEQSIQA---G 522
L+ Q ++ ++L+ S +DD+ ++ EL R L+ + T+LE + A
Sbjct: 1560 LERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDA 1619
Query: 523 RVQLETIIKSLKSTQDEINQARSKLSQLHESRQEAHRSL 561
+++LE +++LK+ + Q R + + E R++ + L
Sbjct: 1620 KLRLEVTVQALKTQHERDLQGRDEAGE--ERRRQLAKQL 1656
Score = 37.0 bits (84), Expect = 0.079
Identities = 53/247 (21%), Positives = 106/247 (42%), Gaps = 46/247 (18%)
Query: 383 VKELDD--ISQEIAQLQRE------KYSLEQDIREKEEA----IRQKTSEVQELQNDLDR 430
V EL+D + E A+L+ E K E+D++ ++EA RQ ++++ + + D
Sbjct: 1606 VTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDE 1665
Query: 431 ETSSLQELEAQKQDAQDRLDEMDQQKA--------------KLRDMLSDVRQKCQDETQM 476
E A ++ + L+E+ Q A K++ + ++ ++ ++
Sbjct: 1666 ERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTS 1725
Query: 477 ISSLKTQIQSQESDLKSQEDDLNRAKSEL-------NRLQQEETQLEQSIQAGRVQLETI 529
+ +Q + E LK E ++ R + EL + QQ+ ++ + G + I
Sbjct: 1726 REEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAI 1785
Query: 530 IKSLKSTQDEINQARSKLSQLHESRQEAHRSLEQYDQVLDGAHGASLTDLANLSEGVSLA 589
+ +E Q +L QL E +E + E +L+ + L + +L+ +S A
Sbjct: 1786 L-------EEKRQLEGRLGQLEEELEEEQSNSE----LLNDRYRKLLLQVESLTTELS-A 1833
Query: 590 ERGSFGA 596
ER SF A
Sbjct: 1834 ER-SFSA 1839
Score = 33.5 bits (75), Expect = 0.87
Identities = 21/132 (15%), Positives = 65/132 (49%), Gaps = 3/132 (2%)
Query: 364 RGTPGPDSSGSLGSGEFTGV---KELDDISQEIAQLQREKYSLEQDIREKEEAIRQKTSE 420
RG G + +G+ + T +L +++ Q RE+ + +R E+ +++ +
Sbjct: 1856 RGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQ 1915
Query: 421 VQELQNDLDRETSSLQELEAQKQDAQDRLDEMDQQKAKLRDMLSDVRQKCQDETQMISSL 480
V+E + D+ L++ + + + +L+E +++ ++ + ++++ +D T+ S+
Sbjct: 1916 VEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDVTESAESM 1975
Query: 481 KTQIQSQESDLK 492
++ + + L+
Sbjct: 1976 NREVTTLRNRLR 1987
>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
sapiens]
Length = 1939
Score = 66.2 bits (160), Expect = 1e-10
Identities = 49/210 (23%), Positives = 108/210 (51%), Gaps = 22/210 (10%)
Query: 384 KELDDISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEAQKQ 443
K++DD+ +A++++EK++ E ++ + ++ + + E L +E +LQE Q
Sbjct: 956 KDIDDLELTLAKVEKEKHATENKVKN----LTEEMAGLDETIAKLTKEKKALQEAHQQTL 1011
Query: 444 D----AQDRLDEMDQQKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLKSQED--- 496
D +D+++ + + K KL + D+ + E ++ L+ + E DLK ++
Sbjct: 1012 DDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTM 1071
Query: 497 DLNRAKSELN-RLQQEETQLE------QSIQAGRVQLETIIKSLKS----TQDEINQARS 545
D+ K +L+ +L+++E ++ + QA +QL+ IK L++ ++EI R+
Sbjct: 1072 DIENDKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERA 1131
Query: 546 KLSQLHESRQEAHRSLEQYDQVLDGAHGAS 575
++ + R + R LE+ + L+ A GA+
Sbjct: 1132 SRAKAEKQRSDLSRELEEISERLEEAGGAT 1161
Score = 55.5 bits (132), Expect = 2e-07
Identities = 55/263 (20%), Positives = 117/263 (44%), Gaps = 37/263 (14%)
Query: 384 KELDDISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEAQKQ 443
KE+ ++ +E + + E E +E EE + E +LQ + E SL
Sbjct: 851 KEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADSLA------- 903
Query: 444 DAQDRLDEMDQQKAKLRDMLSDVRQKCQDETQM---ISSLKTQIQSQESDLKSQEDDL-- 498
DA++R D++ + K +L + +V ++ +DE ++ +++ K +++ + S+LK DDL
Sbjct: 904 DAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLEL 963
Query: 499 ---------NRAKSELNRLQQEETQLEQSIQAGRVQLETIIKSLKSTQDEINQARSKLSQ 549
+ ++++ L +E L+++I + + + ++ + T D++ K++
Sbjct: 964 TLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNT 1023
Query: 550 LHESRQEAHRSLEQYDQVLDGAHGASLTDLANLSEGVSLAERGSFGAMDDPFKNKALLFS 609
L +A LEQ L+G SL + + A+R G + L
Sbjct: 1024 L----TKAKIKLEQQVDDLEG----SLEQEKKIRMDLERAKRKLEGDLK--------LAQ 1067
Query: 610 NNTQELHPDPFQTEDPFKSDPFK 632
+T ++ D Q ++ K F+
Sbjct: 1068 ESTMDIENDKQQLDEKLKKKEFE 1090
Score = 52.4 bits (124), Expect = 2e-06
Identities = 40/182 (21%), Positives = 79/182 (43%), Gaps = 14/182 (7%)
Query: 388 DISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEAQKQDAQD 447
D Q +L+ K L Q +++ EE + ++ L+ R + +++L +
Sbjct: 1382 DAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNA 1441
Query: 448 RLDEMDQQKAKLRDMLSDVRQKCQDETQMIS-------SLKTQIQSQESDLKSQEDDLNR 500
+D+++ +L++ +QKC++ + SL T++ ++ + D L
Sbjct: 1442 ACAALDKKQRNFDKILAEWKQKCEETHAELEASQKESRSLSTELFKIKNAYEESLDQLET 1501
Query: 501 AKSELNRLQQEETQLEQSIQAGRVQLETIIKSLKSTQDEINQARSKLSQLHESRQEAHRS 560
K E LQQE + L + I G ++ + K K + E S+L + +EA S
Sbjct: 1502 LKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQE-------KSELQAALEEAEAS 1554
Query: 561 LE 562
LE
Sbjct: 1555 LE 1556
Score = 48.5 bits (114), Expect = 3e-05
Identities = 40/199 (20%), Positives = 89/199 (44%), Gaps = 21/199 (10%)
Query: 386 LDDISQEIAQLQREKYSLEQDIRE------KEEAI--------RQKTSEVQELQNDLDRE 431
L D + QL + K LE I+E EE I R+ E EL+ D+D
Sbjct: 902 LADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDL 961
Query: 432 TSSLQELEAQKQDAQDRLDEMDQQKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDL 491
+L ++E +K ++++ + ++ A L + ++ + T+ +L+ Q DL
Sbjct: 962 ELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKL-------TKEKKALQEAHQQTLDDL 1014
Query: 492 KSQEDDLNRAKSELNRLQQEETQLEQSIQAGRVQLETIIKSLKSTQDEINQARSKLSQLH 551
+++ED +N +L+Q+ LE S++ + + ++ + + ++ A+ +
Sbjct: 1015 QAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIE 1074
Query: 552 ESRQEAHRSLEQYDQVLDG 570
+Q+ L++ + + G
Sbjct: 1075 NDKQQLDEKLKKKEFEMSG 1093
Score = 48.5 bits (114), Expect = 3e-05
Identities = 51/249 (20%), Positives = 108/249 (43%), Gaps = 37/249 (14%)
Query: 372 SGSLGSGEFTGVKELDDISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRE 431
S SL + F ++ ++ L+RE +L+Q+I + E I + + EL+ +
Sbjct: 1478 SRSLSTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQV 1537
Query: 432 TSSLQELEAQKQDAQDRLDEMDQQ----KAKLRDMLSDVRQKCQDETQMISSLKTQ---- 483
EL+A ++A+ L+ + + + +L + S+V +K ++ + I +K
Sbjct: 1538 EQEKSELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQMKRNHIRI 1597
Query: 484 IQSQESDL--------------KSQEDDLNRAKSEL---NRLQQEETQLEQSIQA----G 522
++S +S L K E DLN + +L NR+ E + ++ QA
Sbjct: 1598 VESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQAILKDT 1657
Query: 523 RVQLETIIKSLKSTQDEINQARSKLSQLHESRQEAHRSLEQYD--------QVLDGAHGA 574
++ L+ ++S + ++++ + + L +E +LEQ + ++LD +
Sbjct: 1658 QLHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERV 1717
Query: 575 SLTDLANLS 583
L N S
Sbjct: 1718 QLLHTQNTS 1726
Score = 46.6 bits (109), Expect = 1e-04
Identities = 47/240 (19%), Positives = 111/240 (46%), Gaps = 31/240 (12%)
Query: 370 DSSGSLGSGEFTGVKELDDISQEIAQ-------LQREKYSLEQDIREKEEAIRQKTSEVQ 422
D +L + +++DD+ + Q L+R K LE D++ +E+ ++ Q
Sbjct: 1019 DKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQ 1078
Query: 423 ELQNDLDRETSSLQELEAQKQDAQDRLDEMDQQKAKLRDMLSDVRQKCQDETQMISSLKT 482
+L L ++ + L+++ +D Q M QK K++++ + + ++ ++E + + +
Sbjct: 1079 QLDEKLKKKEFEMSGLQSKIEDEQAL--GMQLQK-KIKELQARI-EELEEEIEAERASRA 1134
Query: 483 QIQSQESDLKSQEDDLNR----------AKSELNRLQQEETQ-LEQSIQAGRVQLETIIK 531
+ + Q SDL + ++++ A+ E+N+ ++ E Q + + ++ +Q E
Sbjct: 1135 KAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAA 1194
Query: 532 SL-KSTQDEINQARSKLSQLHESRQEAHRSLEQYDQVLDGAHGASLTDLANLSEGVSLAE 590
+L K D + + ++ L +Q+ + + +D DLA+ E VS A+
Sbjct: 1195 TLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEID--------DLASNMETVSKAK 1246
Score = 45.1 bits (105), Expect = 3e-04
Identities = 32/190 (16%), Positives = 89/190 (46%), Gaps = 13/190 (6%)
Query: 386 LDDISQEIAQLQREKYSLEQDIREKEEAIRQK-------TSEVQELQNDLDRETSSLQEL 438
++D++ + A+LQ E + + EK+ + Q T +++EL+ L+ E + L
Sbjct: 1274 INDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEELKRQLEEEIKAKSAL 1333
Query: 439 EAQKQDAQDRLDEMDQQKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLKSQEDDL 498
Q ++ D + +Q + ++ +++++ ++ +T+ E+D + ++L
Sbjct: 1334 AHALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTK---YETDAIQRTEEL 1390
Query: 499 NRAKSELNRLQQEETQLEQSIQAGRVQLETIIKSLKSTQDEINQARSKLSQLHESRQEAH 558
AK +L + Q+ E+ ++A + ++ K+ + Q+E+ + + + +
Sbjct: 1391 EEAKKKLAQRLQD---AEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALD 1447
Query: 559 RSLEQYDQVL 568
+ +D++L
Sbjct: 1448 KKQRNFDKIL 1457
Score = 43.9 bits (102), Expect = 6e-04
Identities = 39/194 (20%), Positives = 89/194 (45%), Gaps = 15/194 (7%)
Query: 384 KELDDISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEA--Q 441
K+ D+S+E+ ++ + E +++ +E Q+++ DL+ T + A +
Sbjct: 1138 KQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLR 1197
Query: 442 KQDAQ------DRLDEMDQQKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLKSQE 495
K+ A +++D + + K KL S+++ + D + ++ + E ++ E
Sbjct: 1198 KKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALE 1257
Query: 496 DDLNRAKSELNRLQQEETQLEQSIQAGRVQLETIIKSLKSTQDEINQARSKLSQLHESRQ 555
D L SE+ ++E+ +L + A R +L+T DE + + +SQL +Q
Sbjct: 1258 DQL----SEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKD---TLVSQLSRGKQ 1310
Query: 556 EAHRSLEQYDQVLD 569
+ +E+ + L+
Sbjct: 1311 AFTQQIEELKRQLE 1324
Score = 43.9 bits (102), Expect = 6e-04
Identities = 36/179 (20%), Positives = 89/179 (49%), Gaps = 13/179 (7%)
Query: 384 KELDDISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEAQKQ 443
+ D I E Q E ++ E + +KE R ++E+ +++N + L+ L+ + +
Sbjct: 1451 RNFDKILAEWKQKCEETHA-ELEASQKES--RSLSTELFKIKNAYEESLDQLETLKRENK 1507
Query: 444 DAQDRLDEMDQQKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLKSQED------- 496
+ Q + ++ +Q A+ + ++ + + Q S L+ ++ E+ L+ +E
Sbjct: 1508 NLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAALEEAEASLEHEEGKILRIQL 1567
Query: 497 DLNRAKSELNRLQQEETQLEQSIQAGRVQLETIIKSLKSTQDEINQARSKLSQLHESRQ 555
+LN+ KSE++R E+ + ++ ++ I++S++ST D ++R+ +L + +
Sbjct: 1568 ELNQVKSEVDRKIAEKDEEIDQMKRNHIR---IVESMQSTLDAEIRSRNDAIRLKKKME 1623
Score = 43.5 bits (101), Expect = 8e-04
Identities = 50/238 (21%), Positives = 106/238 (44%), Gaps = 33/238 (13%)
Query: 384 KELDDISQEIAQLQRE--------KYSLEQDIREKEEAIRQKTS---EVQELQNDLDRET 432
+++ + +EI Q++R + +L+ +IR + +AIR K ++ E++ L+
Sbjct: 1578 RKIAEKDEEIDQMKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHAN 1637
Query: 433 SSLQEL-------EAQKQDAQDRLDEMDQQKAKLRDMLSDVRQKCQDETQMISSLKTQIQ 485
E +A +D Q LD+ + + L++ L+ V ++ I L+ ++
Sbjct: 1638 RMAAEALRNYRNTQAILKDTQLHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLE 1697
Query: 486 SQESDLKSQEDDLNRAKSELNRLQQEET-------QLEQSIQAGRVQLETIIKSLKSTQD 538
E K E +L A + L + T +LE I + ++E II+ ++ ++
Sbjct: 1698 QTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIIQEARNAEE 1757
Query: 539 EINQARSKLSQLHE---SRQEAHRSLEQYDQVLDGAHGASLTDLAN-LSEGVSLAERG 592
+ +A + + + E Q+ LE+ + L+ ++ DL + L E LA +G
Sbjct: 1758 KAKKAITDAAMMAEELKKEQDTSAHLERMKKNLE----QTVKDLQHRLDEAEQLALKG 1811
Score = 41.6 bits (96), Expect = 0.003
Identities = 29/189 (15%), Positives = 85/189 (44%), Gaps = 8/189 (4%)
Query: 383 VKELDDISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEAQK 442
++ +D+ +++A ++R L+ +I E + Q + + +L + +Q L Q
Sbjct: 1665 LRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQN 1724
Query: 443 QDAQDRLDEMDQQKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLKSQED---DLN 499
+ +++ ++++ + D+ Q+ ++ + T +LK ++D L
Sbjct: 1725 TSLINTKKKLETDISQIQGEMEDIIQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLE 1784
Query: 500 RAKSELNR----LQQEETQLEQ-SIQAGRVQLETIIKSLKSTQDEINQARSKLSQLHESR 554
R K L + LQ + EQ +++ G+ Q++ + ++ + E+ + + + +
Sbjct: 1785 RMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNVEAVKGL 1844
Query: 555 QEAHRSLEQ 563
++ R +++
Sbjct: 1845 RKHERKVKE 1853
Score = 41.2 bits (95), Expect = 0.004
Identities = 32/174 (18%), Positives = 87/174 (50%), Gaps = 8/174 (4%)
Query: 394 AQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEAQKQDAQDRLDEMD 453
A L +++ + ++ + E ++ + +E++ Q + ++ L +++ +++ D+L+ +
Sbjct: 1444 AALDKKQRNFDKILAEWKQKCEETHAELEASQKESRSLSTELFKIKNAYEESLDQLETLK 1503
Query: 454 QQKAKLRDMLSDVRQKCQDETQMISSL---KTQIQSQESDLKS----QEDDLNRAKSELN 506
++ L+ +SD+ ++ + + I L K Q++ ++S+L++ E L + ++
Sbjct: 1504 RENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAALEEAEASLEHEEGKIL 1563
Query: 507 RLQQEETQLEQSIQAGRVQLETIIKSLKSTQDEINQA-RSKLSQLHESRQEAHR 559
R+Q E Q++ + + + I +K I ++ +S L SR +A R
Sbjct: 1564 RIQLELNQVKSEVDRKIAEKDEEIDQMKRNHIRIVESMQSTLDAEIRSRNDAIR 1617
Score = 30.0 bits (66), Expect = 9.6
Identities = 25/144 (17%), Positives = 67/144 (46%), Gaps = 9/144 (6%)
Query: 383 VKELDDISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQ-------ELQNDLDRETSSL 435
VK+L E QL + ++ I++ E +R+ EV+ E L + +
Sbjct: 1794 VKDLQHRLDEAEQLALK--GGKKQIQKLEARVRELEGEVESEQKRNVEAVKGLRKHERKV 1851
Query: 436 QELEAQKQDAQDRLDEMDQQKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLKSQE 495
+EL Q ++ + + + KL+ + +++ ++ + + ++ + + +L+ E
Sbjct: 1852 KELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNVNLSKFRRIQHELEEAE 1911
Query: 496 DDLNRAKSELNRLQQEETQLEQSI 519
+ + A+S++N+L+ + ++ I
Sbjct: 1912 ERADIAESQVNKLRVKSREVHTKI 1935
>gi|156104908 myosin heavy chain 6 [Homo sapiens]
Length = 1939
Score = 65.9 bits (159), Expect = 2e-10
Identities = 49/212 (23%), Positives = 107/212 (50%), Gaps = 26/212 (12%)
Query: 384 KELDDISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEAQKQ 443
K++DD+ +A++++EK++ E ++ + ++ + + E+ L +E +LQE Q
Sbjct: 954 KDIDDLELTLAKVEKEKHATENKVKN----LTEEMAGLDEIIAKLTKEKKALQEAHQQAL 1009
Query: 444 D----AQDRLDEMDQQKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLKSQED--- 496
D +D+++ + + K KL + D+ + E ++ L+ + E DLK ++
Sbjct: 1010 DDLQVEEDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIM 1069
Query: 497 DLNRAKSEL-NRLQQEETQLEQSIQAGRVQLETII-----KSLKSTQ-------DEINQA 543
DL K +L +L+++E + Q Q +++ E ++ K LK Q +E+
Sbjct: 1070 DLENDKLQLEEKLKKKEFDINQ--QNSKIEDEQVLALQLQKKLKENQARIEELEEELEAE 1127
Query: 544 RSKLSQLHESRQEAHRSLEQYDQVLDGAHGAS 575
R+ +++ + R + R LE+ + L+ A GA+
Sbjct: 1128 RTARAKVEKLRSDLSRELEEISERLEEAGGAT 1159
Score = 55.1 bits (131), Expect = 3e-07
Identities = 55/255 (21%), Positives = 114/255 (44%), Gaps = 23/255 (9%)
Query: 384 KELDDISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEAQKQ 443
KE+ + +E ++ K +LE+ ++E + S +QE +NDL + + Q+
Sbjct: 849 KEMATMKEEFGRI---KETLEKSEARRKELEEKMVSLLQE-KNDLQLQVQAEQD---NLN 901
Query: 444 DAQDRLDEMDQQKAKLRDMLSDVRQKCQDETQM---ISSLKTQIQSQESDLKSQEDDLNR 500
DA++R D++ + K +L + ++ ++ +DE +M +++ K +++ + S+LK DDL
Sbjct: 902 DAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLEL 961
Query: 501 AKSELNRLQQEETQLEQSIQAGRVQLETII----KSLKSTQDEINQARSKLSQLHESRQE 556
+++ + + +++ L+ II K K+ Q+ QA L +
Sbjct: 962 TLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQVEEDKVNS 1021
Query: 557 AHRSLEQYDQVLDGAHGASLTDLANLSEGVSLAERGSFGAMDDPFKNKALLFSNNTQELH 616
+S + +Q +D G SL + + A+R G + L + +L
Sbjct: 1022 LSKSKVKLEQQVDDLEG-SLEQEKKVRMDLERAKRKLEGDLK--------LTQESIMDLE 1072
Query: 617 PDPFQTEDPFKSDPF 631
D Q E+ K F
Sbjct: 1073 NDKLQLEEKLKKKEF 1087
Score = 51.2 bits (121), Expect = 4e-06
Identities = 48/198 (24%), Positives = 97/198 (48%), Gaps = 26/198 (13%)
Query: 388 DISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQEL---QNDLDRETSSLQ----ELEA 440
++ ++I LQR K LE++ E + + TS ++++ + +L++ + +L+ E
Sbjct: 1204 ELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRV 1263
Query: 441 QKQDAQDRLDEMDQQKAKLRDMLSDVRQKCQDETQMISSL---KTQIQSQESDLKSQEDD 497
+ ++AQ L++ Q+AKL+ ++ ++ +++ +IS L K Q DLK Q ++
Sbjct: 1264 KLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEE 1323
Query: 498 LNRAKSELNRLQQE--------ETQLEQSIQAGRVQLETIIKSLKSTQDEINQARSKLS- 548
+AK+ L Q Q E+ +A + +L+ ++ S E+ Q R+K
Sbjct: 1324 EGKAKNALAHALQSARHDCDLLREQYEEETEA-KAELQRVLSKANS---EVAQWRTKYET 1379
Query: 549 ---QLHESRQEAHRSLEQ 563
Q E +EA + L Q
Sbjct: 1380 DAIQRTEELEEAKKKLAQ 1397
Score = 50.1 bits (118), Expect = 9e-06
Identities = 41/164 (25%), Positives = 74/164 (45%), Gaps = 10/164 (6%)
Query: 388 DISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEAQKQDAQD 447
+ +Q A+++R+ L + E E+A R V LQ LD ET S E+ K+ +
Sbjct: 1566 EFNQIKAEIERK---LAEKDEEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLRVKKKMEG 1622
Query: 448 RLDEMDQQKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLKSQEDDLNRAKSELNR 507
L+EM+ Q + M ++ Q + + + SL Q Q D DDL K +
Sbjct: 1623 DLNEMEIQLSHANRMAAE----AQKQVKSLQSLLKDTQIQLDDAVRANDDL---KENIAI 1675
Query: 508 LQQEETQLEQSIQAGRVQLETIIKSLKSTQDEINQARSKLSQLH 551
+++ L+ ++ R +E +S K + E+ + ++ LH
Sbjct: 1676 VERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLH 1719
Score = 49.7 bits (117), Expect = 1e-05
Identities = 35/190 (18%), Positives = 87/190 (45%), Gaps = 1/190 (0%)
Query: 379 EFTGVKE-LDDISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQE 437
EF +KE L+ +L+ + SL Q+ + + ++ + + + + D+ + +
Sbjct: 857 EFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAEERCDQLIKNKIQ 916
Query: 438 LEAQKQDAQDRLDEMDQQKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLKSQEDD 497
LEA+ ++ +RL++ ++ A+L + +C + + I L+ + E + + E+
Sbjct: 917 LEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENK 976
Query: 498 LNRAKSELNRLQQEETQLEQSIQAGRVQLETIIKSLKSTQDEINQARSKLSQLHESRQEA 557
+ E+ L + +L + +A + + + L+ +D++N +L + +
Sbjct: 977 VKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQVEEDKVNSLSKSKVKLEQQVDDL 1036
Query: 558 HRSLEQYDQV 567
SLEQ +V
Sbjct: 1037 EGSLEQEKKV 1046
Score = 49.3 bits (116), Expect = 2e-05
Identities = 33/189 (17%), Positives = 87/189 (46%), Gaps = 8/189 (4%)
Query: 383 VKELDDISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEAQK 442
V+ DD+ + IA ++R L+ ++ E + Q + + +L + +Q L +Q
Sbjct: 1663 VRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQN 1722
Query: 443 QDAQDRLDEMDQQKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLKSQED---DLN 499
++ +M+ +L+ + + Q+C++ + T +LK ++D L
Sbjct: 1723 TSLINQKKKMESDLTQLQSEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLE 1782
Query: 500 RAKSELNR----LQQEETQLEQ-SIQAGRVQLETIIKSLKSTQDEINQARSKLSQLHESR 554
R K + + LQ + EQ +++ G+ QL+ + ++ + E+ + + ++ +
Sbjct: 1783 RMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELEGELEAEQKRNAESVKGM 1842
Query: 555 QEAHRSLEQ 563
+++ R +++
Sbjct: 1843 RKSERRIKE 1851
Score = 48.9 bits (115), Expect = 2e-05
Identities = 36/194 (18%), Positives = 88/194 (45%), Gaps = 13/194 (6%)
Query: 382 GVKELDDISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEAQ 441
G K + ++ + QL+ EK L+ + E E ++ + ++ Q + ++ + ++ A+
Sbjct: 1521 GGKNVHELEKVRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAE 1580
Query: 442 KQDAQDRLDEMDQQKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLKSQEDDLNRA 501
K + EM+Q K + ++ ++ ET+ + + + E DL E L+ A
Sbjct: 1581 KDE------EMEQAKRNHQRVVDSLQTSLDAETRSRNEVLRVKKKMEGDLNEMEIQLSHA 1634
Query: 502 KSELNRLQQEETQLEQSIQAGRVQLETIIKSLKSTQDEI-------NQARSKLSQLHESR 554
Q++ L+ ++ ++QL+ +++ ++ I N +++L +L
Sbjct: 1635 NRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVV 1694
Query: 555 QEAHRSLEQYDQVL 568
++ RS + +Q L
Sbjct: 1695 EQTERSRKLAEQEL 1708
Score = 48.5 bits (114), Expect = 3e-05
Identities = 37/192 (19%), Positives = 89/192 (46%), Gaps = 13/192 (6%)
Query: 384 KELDDISQEIAQLQREKYSLEQDIREKEEAIRQ-------KTSEVQELQNDLDRETSSLQ 436
+ L+D + + A+LQ E L + + EKE I Q T ++++L+ L+ E +
Sbjct: 1270 RSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKN 1329
Query: 437 ELEAQKQDAQDRLDEMDQQKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLKSQED 496
L Q A+ D + +Q + + +++++ ++ +T+ E+D + +
Sbjct: 1330 ALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTK---YETDAIQRTE 1386
Query: 497 DLNRAKSELNRLQQEETQLEQSIQAGRVQLETIIKSLKSTQDEINQARSKLSQLHESRQE 556
+L AK +L + Q+ E++++A + ++ K+ Q+EI + + + +
Sbjct: 1387 ELEEAKKKLAQRLQD---AEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAA 1443
Query: 557 AHRSLEQYDQVL 568
+ +D++L
Sbjct: 1444 LDKKQRNFDKIL 1455
Score = 48.5 bits (114), Expect = 3e-05
Identities = 33/175 (18%), Positives = 78/175 (44%)
Query: 388 DISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEAQKQDAQD 447
D Q +L+ K L Q +++ EEA+ ++ L+ R + +++L + +
Sbjct: 1380 DAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNA 1439
Query: 448 RLDEMDQQKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLKSQEDDLNRAKSELNR 507
+D+++ +L++ +QK ++ + S + + +S ++L ++ + L
Sbjct: 1440 AAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLET 1499
Query: 508 LQQEETQLEQSIQAGRVQLETIIKSLKSTQDEINQARSKLSQLHESRQEAHRSLE 562
++E L++ I QL K++ + Q + +L + +EA SLE
Sbjct: 1500 FKRENKNLQEEISDLTEQLGEGGKNVHELEKVRKQLEVEKLELQSALEEAEASLE 1554
Score = 48.1 bits (113), Expect = 3e-05
Identities = 48/221 (21%), Positives = 96/221 (43%), Gaps = 58/221 (26%)
Query: 391 QEIAQLQREKYSLEQDIREKEEAIRQKTSEVQE-------LQNDLDRETSSLQELEAQ-- 441
+ I L+ +K LE+ +++KE I Q+ S++++ LQ L + ++ELE +
Sbjct: 1066 ESIMDLENDKLQLEEKLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEELEEELE 1125
Query: 442 ------------KQDAQDRLDEMDQ------------------QKAKLRDMLSDVRQKCQ 471
+ D L+E+ + ++A+ + M D+ +
Sbjct: 1126 AERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATL 1185
Query: 472 DETQMISSLKTQIQSQESDLKSQEDDLNRAKSELNRLQQE--------ETQLEQSIQAGR 523
++L+ + ++L Q D+L R K +L + + E + +EQ I+A +
Sbjct: 1186 QHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKA-K 1244
Query: 524 VQLETIIKSLKSTQDEINQARSKLSQLHESRQEAHRSLEQY 564
LE + ++L +D+ N+ R KL +EA RSL +
Sbjct: 1245 ANLEKVSRTL---EDQANEYRVKL-------EEAQRSLNDF 1275
Score = 46.2 bits (108), Expect = 1e-04
Identities = 40/184 (21%), Positives = 89/184 (48%), Gaps = 14/184 (7%)
Query: 386 LDDISQEIAQLQREKYSLE--QDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEAQKQ 443
L + E+AQ R KY + Q E EEA ++ +Q+ + ++ + LE K
Sbjct: 1363 LSKANSEVAQW-RTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKH 1421
Query: 444 DAQDRLDEM--DQQKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLKSQEDDLNRA 501
Q+ ++++ D +++ D +Q+ D+ +++ K + + +S+L+S + +
Sbjct: 1422 RLQNEIEDLMVDVERSNAAAAALDKKQRNFDK--ILAEWKQKYEESQSELESSQKEARSL 1479
Query: 502 KSELNRLQQEETQLEQSIQAGRVQLETIIKSLKSTQDEINQARSKLSQLHESRQEAHRSL 561
+EL +L+ E+S++ LET + K+ Q+EI+ +L + ++ E +
Sbjct: 1480 STELFKLKNA---YEESLE----HLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKVR 1532
Query: 562 EQYD 565
+Q +
Sbjct: 1533 KQLE 1536
Score = 45.1 bits (105), Expect = 3e-04
Identities = 47/229 (20%), Positives = 96/229 (41%), Gaps = 36/229 (15%)
Query: 375 LGSGEFTGVKELDDISQEIAQLQREKYSLE---QDIREKEEAIRQKTSEVQELQNDLDRE 431
L G+ + ++++D+ +++ + + K +L Q R + +R++ E E + +L R
Sbjct: 1303 LTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRV 1362
Query: 432 TSSLQELEAQ-----KQDAQDRLDEMDQQKAKLRDMLSDVRQKCQDETQMISSL---KTQ 483
S AQ + DA R +E+++ K KL L D + + SSL K +
Sbjct: 1363 LSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHR 1422
Query: 484 IQSQESDLKSQEDDLNRA-------------------------KSELNRLQQEETQLEQS 518
+Q++ DL + N A +SEL Q+E L
Sbjct: 1423 LQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTE 1482
Query: 519 IQAGRVQLETIIKSLKSTQDEINQARSKLSQLHESRQEAHRSLEQYDQV 567
+ + E ++ L++ + E + ++S L E E +++ + ++V
Sbjct: 1483 LFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKV 1531
>gi|87298937 centrosomal protein 110kDa [Homo sapiens]
Length = 2325
Score = 65.9 bits (159), Expect = 2e-10
Identities = 56/222 (25%), Positives = 106/222 (47%), Gaps = 22/222 (9%)
Query: 384 KELDDISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQ---NDLDRETSSLQELEA 440
K+L Q + +L++E LE + ++++ I K E+++LQ + LD + ++A
Sbjct: 496 KQLSGRLQLVNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAIDSLDSKDPKHSHMKA 555
Query: 441 QKQDAQDRLDEMDQQKAKLRDMLSDVRQKCQDETQMISSLKT-----QIQSQESDLKSQE 495
QK + +LD M++Q +L L ++ + ET+ I L+ QI + E+ K E
Sbjct: 556 QKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEGQIAANEALKKDLE 615
Query: 496 DDLNRAKSELNRLQQEETQLEQSIQAGRVQLETIIKSLKSTQDEINQ----------ARS 545
++ + L ++ + TQ + + R + ET+++ L + E +Q R
Sbjct: 616 GVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVAMDAENMRK 675
Query: 546 KLSQLHESRQEAHR---SLEQYDQVLDGAHGASLTDLANLSE 584
+L++L + QE H SL+Q L A+ A L NL +
Sbjct: 676 ELAELESALQEQHEVNASLQQTQGDL-SAYEAELEARLNLRD 716
Score = 60.1 bits (144), Expect = 9e-09
Identities = 43/181 (23%), Positives = 89/181 (49%), Gaps = 7/181 (3%)
Query: 396 LQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEAQKQDAQDRLDEMDQQ 455
L +EK L++ E+ + Q + + + E S+L++LE + Q LD++++
Sbjct: 1785 LSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRD 1844
Query: 456 KAKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLKSQEDDLNRAKSELNRLQQEETQL 515
K L + +S ++Q+ Q++ + ++SL+ ++ + + L + DL + L E+T+L
Sbjct: 1845 KLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRL 1904
Query: 516 EQSIQ--AGRVQ-----LETIIKSLKSTQDEINQARSKLSQLHESRQEAHRSLEQYDQVL 568
++ I A R + ET + L+ Q+EI + + KL Q Q + E + L
Sbjct: 1905 QKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKL 1964
Query: 569 D 569
+
Sbjct: 1965 E 1965
Score = 57.0 bits (136), Expect = 7e-08
Identities = 47/191 (24%), Positives = 92/191 (48%), Gaps = 15/191 (7%)
Query: 389 ISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQE-LEAQKQDAQD 447
+ QE+ QL R+K SL DI A++Q+ E +E N L E +++Q+ L KQD
Sbjct: 1834 LQQELDQLNRDKLSLHNDI----SAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLH 1889
Query: 448 RLDEMD---QQKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLKSQEDDLNRAKSE 504
D ++ +L+ +S+ + +D + + + Q+Q +++++ + L + +
Sbjct: 1890 TTKHQDVLLSEQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMM 1949
Query: 505 LNRLQQEETQLEQSIQAGRVQLE----TIIKSLKSTQDEINQARSKLSQLHE---SRQEA 557
RLQ+E E ++ +V L+ + K L + +++Q SK+ E + QE
Sbjct: 1950 FQRLQKERESEESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEE 2009
Query: 558 HRSLEQYDQVL 568
R E ++ L
Sbjct: 2010 ERWCESLEKTL 2020
Score = 52.4 bits (124), Expect = 2e-06
Identities = 33/177 (18%), Positives = 95/177 (53%), Gaps = 5/177 (2%)
Query: 375 LGSGEFTGVKELDDISQEIAQLQREKYSLEQDIREKE---EAIRQKTSEVQELQNDLDRE 431
L + E G+K D Q +++L++ + ++ ++ E E + +Q+ E++ + L+R+
Sbjct: 1707 LENHELQGLKLQHD--QRVSELEKTQVAVLEEKLELENLQQISQQQKGEIEWQKQLLERD 1764
Query: 432 TSSLQELEAQKQDAQDRLDEMDQQKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDL 491
++ + A+ + Q ++ + ++K L++ +K +++++ + + ++S+L
Sbjct: 1765 KREIERMTAESRALQSCVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNL 1824
Query: 492 KSQEDDLNRAKSELNRLQQEETQLEQSIQAGRVQLETIIKSLKSTQDEINQARSKLS 548
+ E ++ + + EL++L +++ L I A + QL+ +++ S Q+E+ + L+
Sbjct: 1825 EKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLN 1881
Score = 52.0 bits (123), Expect = 2e-06
Identities = 46/195 (23%), Positives = 87/195 (44%), Gaps = 26/195 (13%)
Query: 386 LDDISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEAQKQDA 445
LD + E +LQ K +Q + E E+ E EL+N E+E QKQ
Sbjct: 1702 LDMLQLENHELQGLKLQHDQRVSELEKTQVAVLEEKLELENLQQISQQQKGEIEWQKQLL 1761
Query: 446 QDRLDEMDQQKAKLRDMLS----------DVRQKCQDETQMISSLKTQIQSQESDLKSQE 495
+ E+++ A+ R + S D+++KC + ++ K + + E + K ++
Sbjct: 1762 ERDKREIERMTAESRALQSCVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQ 1821
Query: 496 DDLNRAKSELNRLQQEETQL--------------EQSIQAGRVQLETIIKSLKSTQDEIN 541
+L + + + +LQQE QL +Q +Q R + ++ + L + QD +N
Sbjct: 1822 SNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLN 1881
Query: 542 QARSKLSQLHESRQE 556
A+ L LH ++ +
Sbjct: 1882 LAKQDL--LHTTKHQ 1894
Score = 50.8 bits (120), Expect = 5e-06
Identities = 43/200 (21%), Positives = 91/200 (45%), Gaps = 22/200 (11%)
Query: 384 KELDDISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEAQKQ 443
++L + + L++ K E+ ++E + + K S+ Q L ++ T LQ+L+ +
Sbjct: 1496 QQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIE 1555
Query: 444 DAQDRLDEMDQQKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLKSQEDDLNRAKS 503
A+ D Q +L + Q + + LK+Q+ SQ+ ++ + L K
Sbjct: 1556 MAERNEDHHLQ-------VLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKE 1608
Query: 504 ELNRLQ----QEETQLEQSIQAGRV----------QLETIIKSLKSTQDEIN-QARSKLS 548
EL+ LQ Q + L+++++ G +++++++ L + E+N Q + +
Sbjct: 1609 ELHLLQGSMVQAKADLQEALRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQISERKT 1668
Query: 549 QLHESRQEAHRSLEQYDQVL 568
QL +QE + E VL
Sbjct: 1669 QLTLIKQEIEKEEENLQVVL 1688
Score = 48.9 bits (115), Expect = 2e-05
Identities = 78/385 (20%), Positives = 148/385 (38%), Gaps = 47/385 (12%)
Query: 205 PPSLIPPSKRKKTVFPGAVPV-----LPASPPPKDSLRSTPSHGSVSSLNSTGSLSPKHS 259
PP + PP TV P PV L A PPP + + G+V G
Sbjct: 1236 PPFVPPPGYMMYTVLPDGSPVPQGMALYAPPPPLPNNSRPLTPGTVVY----GPPPAGAP 1291
Query: 260 LKQTQPTVNWVVPVADKMRFDEIFLKTDLDLDGYVSGQEVKEIFMHSGLTQNLLAHIWAL 319
+ P N+ +P M + +L+ VS +++I H L W
Sbjct: 1292 MVYGPPPPNFSIPFIP-MGVLHCNVPEHHNLENEVS--RLEDIMQH--LKSKKREERWMR 1346
Query: 320 ADTRQTGKLSKDQFALAMYFIQQKVSKGIDPPQVLSPDMVPPSERGTPGPDSSGSLGSGE 379
A RQ+ K ++ +Q+K S + ++ ++ + + E
Sbjct: 1347 ASKRQSEKEMEELHHNIDDLLQEKKSLECEVEELHRTVQKRQQQKDFIDGNVESLMTELE 1406
Query: 380 FT-GVKELDDISQEIAQLQREKYSLEQDIREKEEAIRQKTSEV----QELQNDLDRET-- 432
+K +DI EI +++ ++RE + + + SE+ ++ +N +++ T
Sbjct: 1407 IEKSLKHHEDIVDEIECIEKTLLKRRSELREADRLLAEAESELSCTKEKTKNAVEKFTDA 1466
Query: 433 --------SSLQELEAQKQDAQDRLDEMDQQKAKLRDMLSDVRQKCQDETQMISSLKTQI 484
S +ELE + Q+ L + DQQ L+ D+ Q + +++ + +
Sbjct: 1467 KRSLLQTESDAEELERRAQETAVNLVKADQQLRSLQADAKDLEQHKIKQEEILKEINKIV 1526
Query: 485 QSQESDLKSQEDDLNRAKSELNRLQQEETQLEQS--------------IQAGRVQLETII 530
+++SD + + EL +LQ++ E++ +QA R +LE +
Sbjct: 1527 AAKDSDFQCLSKKKEKLTEELQKLQKDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLK 1586
Query: 531 KSLKSTQDEI----NQARSKLSQLH 551
+ S Q E+ Q K +LH
Sbjct: 1587 SQVTSQQQEMAVLDRQLGHKKEELH 1611
Score = 48.1 bits (113), Expect = 3e-05
Identities = 39/178 (21%), Positives = 79/178 (44%), Gaps = 13/178 (7%)
Query: 389 ISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEAQKQDAQDR 448
IS+ QL K +E++ + +RQ + EL+N LD EL+ K R
Sbjct: 1663 ISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQR 1722
Query: 449 LDEMDQ-QKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLKSQEDDLNRAKSELNR 507
+ E+++ Q A L + L + +L+ Q Q+ +++ Q+ L R K E+ R
Sbjct: 1723 VSELEKTQVAVLEEKLE------------LENLQQISQQQKGEIEWQKQLLERDKREIER 1770
Query: 508 LQQEETQLEQSIQAGRVQLETIIKSLKSTQDEINQARSKLSQLHESRQEAHRSLEQYD 565
+ E L+ ++ + E + + + ++ Q + L+ E+ + +LE+ +
Sbjct: 1771 MTAESRALQSCVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLE 1828
Score = 47.0 bits (110), Expect = 8e-05
Identities = 45/190 (23%), Positives = 84/190 (44%), Gaps = 23/190 (12%)
Query: 383 VKELDDISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEAQK 442
+ LD + + ++ +K EQ + + +Q S + E+ + + +ET +++LE Q
Sbjct: 540 IDSLDSKDPKHSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQL 599
Query: 443 QDAQDRLDEMDQQKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLKSQEDDLNRAK 502
+ Q +E L+ L V Q+ I TQ Q++ L+ +++ L
Sbjct: 600 TEGQIAANE------ALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETL---- 649
Query: 503 SELNRLQQEETQLEQSIQAGRVQLETIIKSLKSTQDEINQARSKLSQLHE---SRQEAHR 559
L RL T++EQ R QLE + ++ + E+ + S L + HE S Q+
Sbjct: 650 --LQRL----TEVEQE----RDQLEIVAMDAENMRKELAELESALQEQHEVNASLQQTQG 699
Query: 560 SLEQYDQVLD 569
L Y+ L+
Sbjct: 700 DLSAYEAELE 709
Score = 47.0 bits (110), Expect = 8e-05
Identities = 43/191 (22%), Positives = 92/191 (48%), Gaps = 18/191 (9%)
Query: 384 KELDDISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEAQKQ 443
+EL + ++I +R + Q ++E E ++ K +E+++L++ + TS QE+ +
Sbjct: 1545 EELQKLQKDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQV---TSQQQEMAVLDR 1601
Query: 444 DAQDRLDE-------MDQQKAKLRDML----SDVRQKCQDETQMISSLKTQIQSQESDLK 492
+ +E M Q KA L++ L ++V +KC + + + SL ++ Q+ +L
Sbjct: 1602 QLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKC-NHIREVKSLLEELSFQKGELN 1660
Query: 493 SQEDDLNRAKSELNRLQQEETQLEQSIQAGRVQLETIIKSLKSTQDEINQARSKLSQLHE 552
Q ++ K++L ++QE + E+++Q Q+ LK+ D + +L L
Sbjct: 1661 VQ---ISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKL 1717
Query: 553 SRQEAHRSLEQ 563
+ LE+
Sbjct: 1718 QHDQRVSELEK 1728
Score = 46.6 bits (109), Expect = 1e-04
Identities = 49/225 (21%), Positives = 101/225 (44%), Gaps = 11/225 (4%)
Query: 383 VKELDDISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEAQK 442
V+ L + + L++ ++ + E+E+ + +K+ E+ LQ + D + L Q
Sbjct: 2003 VRTLQEEERWCESLEKTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRADFSLLRNQF 2062
Query: 443 QDAQDRLD-EMDQQKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLKSQEDDLNRA 501
+ + + ++ K L+ S + + ++ Q S ++ ++ + E + + R
Sbjct: 2063 LTERKKAEKQVASLKEALKIQRSQLEKNLLEQKQENSCIQKEMATIELVAQDNHERARRL 2122
Query: 502 KSELNRLQQEETQLEQSIQAGRVQLETIIKSLKSTQDEINQA-RSKLSQLHESRQEAHRS 560
ELN++Q E T+L++ + K L+ Q EI+ A R+ S++ + + + ++
Sbjct: 2123 MKELNQMQYEYTELKKQMANQ--------KDLERRQMEISDAMRTLKSEVKDEIRTSLKN 2174
Query: 561 LEQYDQVLDGAHGASLTDLANL-SEGVSLAERGSFGAMDDPFKNK 604
L Q+ L A L NL E SL E F + PF+ K
Sbjct: 2175 LNQFLPELPADLEAILERNENLEGELESLKENLPFTMNEGPFEEK 2219
Score = 46.2 bits (108), Expect = 1e-04
Identities = 44/236 (18%), Positives = 100/236 (42%), Gaps = 28/236 (11%)
Query: 393 IAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEAQKQ----DAQDR 448
I Q++ E + L+++++ EE ++QE + +R + L+ELE +K+ +Q++
Sbjct: 909 IQQMENEIHYLQENLKSMEEIQGLTDLQLQEADEEKERILAQLRELEKKKKLEDAKSQEQ 968
Query: 449 LDEMDQQKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLKSQEDDLNRAKSELNRL 508
+ +D++ KL+ ++ + T ++ K Q++S + + E R
Sbjct: 969 VFGLDKELKKLKKAVATSDKLA---TAELTIAKDQLKSLHGTVMKINQERAEELQEAERF 1025
Query: 509 QQEETQLEQSIQAGRVQLETIIKSLKSTQDEI-------------NQARSKLSQLHESRQ 555
++ Q + + ++E + L+ ++ N ++ +L+E+ +
Sbjct: 1026 SRKAAQAARDLTRAEAEIELLQNLLRQKGEQFRLEMEKTGVGTGANSQVLEIEKLNETME 1085
Query: 556 EAHRSLEQYDQVLD-------GAHGASLTDLANLSEGVSLAERGSFGAMDDPFKNK 604
+ + VLD G L ++A L VS + +M DPFK +
Sbjct: 1086 RQRTEIARLQNVLDLTGSDNKGGFENVLEEIAELRREVSY-QNDYISSMADPFKRR 1140
Score = 46.2 bits (108), Expect = 1e-04
Identities = 39/186 (20%), Positives = 78/186 (41%), Gaps = 12/186 (6%)
Query: 383 VKELDDISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEAQK 442
V L+DI Q + +RE+ R + RQ E++EL +++D + LE +
Sbjct: 1325 VSRLEDIMQHLKSKKREE-------RWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEV 1377
Query: 443 QDAQDRLDEMDQQKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLKSQEDDLNRAK 502
++ + + QQK D + + E ++ SLK + +++ E L + +
Sbjct: 1378 EELHRTVQKRQQQK----DFIDGNVESLMTELEIEKSLKHH-EDIVDEIECIEKTLLKRR 1432
Query: 503 SELNRLQQEETQLEQSIQAGRVQLETIIKSLKSTQDEINQARSKLSQLHESRQEAHRSLE 562
SEL + + E + + + + ++ + + Q S +L QE +L
Sbjct: 1433 SELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLV 1492
Query: 563 QYDQVL 568
+ DQ L
Sbjct: 1493 KADQQL 1498
Score = 45.4 bits (106), Expect = 2e-04
Identities = 41/186 (22%), Positives = 84/186 (45%), Gaps = 24/186 (12%)
Query: 384 KELDDISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEAQKQ 443
++L +E+ LQ + D+ +EA+R +EV E N + S L+EL QK
Sbjct: 1601 RQLGHKKEELHLLQGSMVQAKADL---QEALRLGETEVTEKCNHIREVKSLLEELSFQK- 1656
Query: 444 DAQDRLDEMDQQKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLKSQEDDLNRAKS 503
E++ Q ++ + L+ ++Q+ + E + + + Q+ +++LK+ D L
Sbjct: 1657 ------GELNVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNILDMLQLENH 1710
Query: 504 ELNRLQQEETQLEQSIQAGRVQLETIIKSLKSTQDEINQARSKLSQLHESRQEAHRSLEQ 563
EL L ++Q + + L+ TQ + + + +L L + Q+ +E
Sbjct: 1711 ELQGL--------------KLQHDQRVSELEKTQVAVLEEKLELENLQQISQQQKGEIEW 1756
Query: 564 YDQVLD 569
Q+L+
Sbjct: 1757 QKQLLE 1762
Score = 45.1 bits (105), Expect = 3e-04
Identities = 56/234 (23%), Positives = 101/234 (43%), Gaps = 58/234 (24%)
Query: 386 LDDISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQE-------- 437
LD+I IA+ E LE+ + E + A + L+ DL+ S LQE
Sbjct: 578 LDEILSRIAKETEEIKDLEEQLTEGQIAANEA------LKKDLEGVISGLQEYLGTIKGQ 631
Query: 438 ----------LEAQKQDAQDRLDEMDQQKAKLRDMLSDVRQKCQDETQMISSLKTQ---- 483
L +K+ RL E++Q++ +L + D ++ ++ S+L+ Q
Sbjct: 632 ATQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKELAELESALQEQHEVN 691
Query: 484 --IQSQESDLKSQEDDL-----------NRAKSELNRLQQEETQLEQSIQAGRVQLETII 530
+Q + DL + E +L N+ K EL ++ + TQLEQS A + +LE
Sbjct: 692 ASLQQTQGDLSAYEAELEARLNLRDAEANQLKEELEKVTR-LTQLEQS--ALQAELEKER 748
Query: 531 KSLKST----------QDEINQARSKLSQLHESRQEAHRSLEQY----DQVLDG 570
++LK+ + E ++ +KL L + + L+ + + V+DG
Sbjct: 749 QALKNALGKAQFSEEKEQENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHVVDG 802
Score = 45.1 bits (105), Expect = 3e-04
Identities = 50/212 (23%), Positives = 92/212 (43%), Gaps = 22/212 (10%)
Query: 391 QEIAQLQREKYSLEQDIREKEEAIRQKTSEVQEL---QNDLDRETSS--------LQELE 439
Q A LQ E ++ EK IR+ S ++EL + +L+ + S QE+E
Sbjct: 1619 QAKADLQEALRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQISERKTQLTLIKQEIE 1678
Query: 440 AQKQDAQDRLDEMDQQKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLKSQEDDLN 499
++++ Q L +M + K +L+++L Q E + LK Q + S+L+ + +
Sbjct: 1679 KEEENLQVVLRQMSKHKTELKNIL----DMLQLENHELQGLKLQHDQRVSELEKTQVAVL 1734
Query: 500 RAKSELNRLQQEETQ-------LEQSIQAGRVQLETIIKSLKSTQDEINQARSKLSQLHE 552
K EL LQQ Q +Q ++ + ++E + ++ Q + + L E
Sbjct: 1735 EEKLELENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQSCVECLSKEKEDLQE 1794
Query: 553 SRQEAHRSLEQYDQVLDGAHGASLTDLANLSE 584
+ L Q +VL A S + +NL +
Sbjct: 1795 KCDIWEKKLAQTKRVLAAAEENSKMEQSNLEK 1826
Score = 43.9 bits (102), Expect = 6e-04
Identities = 44/219 (20%), Positives = 103/219 (47%), Gaps = 23/219 (10%)
Query: 384 KELDDISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQ------- 436
KE +++ + Q+ + K L+ + + ++ + E+Q L+ D+ S L+
Sbjct: 1679 KEEENLQVVLRQMSKHKTELKNIL----DMLQLENHELQGLKLQHDQRVSELEKTQVAVL 1734
Query: 437 ----ELEAQKQDAQDRLDEMDQQKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLK 492
ELE +Q +Q + E++ QK L ++ ++ E++ + S + ++ DL+
Sbjct: 1735 EEKLELENLQQISQQQKGEIEWQKQLLERDKREI-ERMTAESRALQSCVECLSKEKEDLQ 1793
Query: 493 SQEDDLNRAKSELNRLQQEETQLEQSIQAGRVQLETIIKSLKSTQDEINQARSKLSQLHE 552
+ D + ++ R+ + + Q+ +LE ++ L+ D++N R KLS LH
Sbjct: 1794 EKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLN--RDKLS-LHN 1850
Query: 553 SRQEAHRSLEQYDQVLDGAHGASLTDLANLSEGVSLAER 591
+ L++ + ++ +LAN+ + ++LA++
Sbjct: 1851 DISAMQQQLQEKREAVNSLQ----EELANVQDHLNLAKQ 1885
Score = 43.1 bits (100), Expect = 0.001
Identities = 45/208 (21%), Positives = 89/208 (42%), Gaps = 16/208 (7%)
Query: 377 SGEFTGVKELDDI-SQEIAQLQR------EKYSLEQDIREKEEA-IRQKTSEVQELQNDL 428
S E ++E DI +++AQ +R E +EQ EK E +R+ E+ +L D
Sbjct: 1786 SKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDK 1845
Query: 429 DRETSSLQELEAQKQDAQDRLDEMDQQKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQE 488
+ + ++ Q Q+ ++ ++ + ++ A ++D L+ +Q T+ L ++ +
Sbjct: 1846 LSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQ 1905
Query: 489 SDLKSQEDDLNRAKSELNRLQQEETQLEQSIQAGRVQLETIIKSLKSTQDEINQARSKL- 547
D+ + + E QQ+ L+ I+ +++L + Q E SKL
Sbjct: 1906 KDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLE 1965
Query: 548 -------SQLHESRQEAHRSLEQYDQVL 568
Q H+ +E + DQVL
Sbjct: 1966 TSKVTLKEQQHQLEKELTDQKSKLDQVL 1993
Score = 42.7 bits (99), Expect = 0.001
Identities = 50/203 (24%), Positives = 86/203 (42%), Gaps = 44/203 (21%)
Query: 396 LQREKYSLEQDIRE---------KEEAIRQKTSEVQELQNDLDRETSSL-------QELE 439
L E+ L++DI E KEE +Q+ ++Q LQN+++ L Q L+
Sbjct: 1897 LLSEQTRLQKDISEWANRFEDCQKEEETKQQ--QLQVLQNEIEENKLKLVQQEMMFQRLQ 1954
Query: 440 AQKQDAQDRLD---------------EMDQQKAKLRDMLSDVR------QKCQDETQMIS 478
+++ + +L+ E+ QK+KL +LS V + Q+E +
Sbjct: 1955 KERESEESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCE 2014
Query: 479 SLKTQIQSQESDLKSQEDDLNRAKSELNRLQQEETQLEQSIQAGRVQLET----IIKSLK 534
SL+ + + L +E L EL LQ+E + R Q T K +
Sbjct: 2015 SLEKTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVA 2074
Query: 535 STQDEINQARSKLSQ-LHESRQE 556
S ++ + RS+L + L E +QE
Sbjct: 2075 SLKEALKIQRSQLEKNLLEQKQE 2097
Score = 40.4 bits (93), Expect = 0.007
Identities = 35/172 (20%), Positives = 81/172 (47%), Gaps = 19/172 (11%)
Query: 408 REKEEAI-RQKTSEVQELQNDLDRETSSLQELEAQKQDAQDRLDEMDQQKAKLRDMLSDV 466
++++EA R EV+ L+ DL+++ +EL++++ + + D+ L++
Sbjct: 258 QDRQEAFERFSLEEVERLERDLEKKMIETEELKSKQTRFLEEIKNQDKLNKSLKEEAMLQ 317
Query: 467 RQKCQDETQMISSLKTQIQSQESDLKSQEDDLNRAKSELNRLQQEETQLEQSIQAGRVQL 526
+Q C++ +SDL ++ + L + EL R Q++ +LEQ + ++
Sbjct: 318 KQSCEE--------------LKSDLNTKNELLKQKTIELTRACQKQYELEQELAFYKIDA 363
Query: 527 E-TIIKSLKSTQDEINQARSKLSQLHESRQEAHR-SLEQYDQVLDGAHGASL 576
+ + S EI++A + + +SR + + + E Y ++D A +
Sbjct: 364 KFEPLNYYPSEYAEIDKAPDESPYIGKSRYKRNMFATESY--IIDSAQAVQI 413
Score = 40.4 bits (93), Expect = 0.007
Identities = 37/211 (17%), Positives = 100/211 (47%), Gaps = 37/211 (17%)
Query: 391 QEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEAQKQDAQDRLD 450
+E+ +L+R+ LE+ + E EE ++T ++E++N S +E QKQ ++
Sbjct: 270 EEVERLERD---LEKKMIETEELKSKQTRFLEEIKNQDKLNKSLKEEAMLQKQSCEELKS 326
Query: 451 EMDQQKAKLRDMLSDVRQKCQDETQMISSLK-----------TQIQSQESDLKSQEDD-- 497
+++ + L+ ++ + CQ + ++ L S+ +++ D+
Sbjct: 327 DLNTKNELLKQKTIELTRACQKQYELEQELAFYKIDAKFEPLNYYPSEYAEIDKAPDESP 386
Query: 498 -LNRAKSELNRLQQEETQLE--QSIQAGRVQLETIIKS--------------LKSTQDEI 540
+ +++ + N E ++ Q++Q +++ + +++ L+ + +I
Sbjct: 387 YIGKSRYKRNMFATESYIIDSAQAVQIKKMEPDEQLRNDHMNLRGHTPLDTQLEDKEKKI 446
Query: 541 NQARSKLSQLHE----SRQEAHRSLEQYDQV 567
+ A+++LS+LH+ + Q+ R+ E++ Q+
Sbjct: 447 SAAQTRLSELHDEIEKAEQQILRATEEFKQL 477
Score = 35.4 bits (80), Expect = 0.23
Identities = 39/196 (19%), Positives = 95/196 (48%), Gaps = 28/196 (14%)
Query: 377 SGEFTGV-KELDDISQEIAQLQR----EKYSLEQDIREKEEAIRQKTSEVQELQNDLDRE 431
SGE + KE D + + + L+ E+ E+ + +EA++ + S++++ + +E
Sbjct: 2038 SGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVASLKEALKIQRSQLEKNLLEQKQE 2097
Query: 432 TSSLQE----LEAQKQDAQDR-------LDEMDQQKAKLRDMLS---DVRQKCQDETQMI 477
S +Q+ +E QD +R L++M + +L+ ++ D+ ++ + + +
Sbjct: 2098 NSCIQKEMATIELVAQDNHERARRLMKELNQMQYEYTELKKQMANQKDLERRQMEISDAM 2157
Query: 478 SSLKTQIQSQ-ESDLKSQEDDLNRAKSELNRLQQEETQLEQSIQAGRVQLETIIKSLKST 536
+LK++++ + + LK+ L ++L + + LE +LE++ ++L T
Sbjct: 2158 RTLKSEVKDEIRTSLKNLNQFLPELPADLEAILERNENLEG-------ELESLKENLPFT 2210
Query: 537 QDE-INQARSKLSQLH 551
+E + + SQ+H
Sbjct: 2211 MNEGPFEEKLNFSQVH 2226
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.311 0.130 0.373
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 37,581,740
Number of Sequences: 37866
Number of extensions: 2136481
Number of successful extensions: 27028
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 661
Number of HSP's successfully gapped in prelim test: 1359
Number of HSP's that attempted gapping in prelim test: 13259
Number of HSP's gapped (non-prelim): 9861
length of query: 864
length of database: 18,247,518
effective HSP length: 111
effective length of query: 753
effective length of database: 14,044,392
effective search space: 10575427176
effective search space used: 10575427176
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.