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Search of human proteins with 117168263
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|117168263 RasGEF domain family, member 1A [Homo sapiens]
(481 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|117168263 RasGEF domain family, member 1A [Homo sapiens] 974 0.0
gi|22749129 RasGEF domain family, member 1B [Homo sapiens] 570 e-163
gi|40255197 RasGEF domain family, member 1C [Homo sapiens] 491 e-139
gi|4758532 ral guanine nucleotide dissociation stimulator-like 2... 97 3e-20
gi|7657261 Rap guanine nucleotide exchange factor 2 [Homo sapiens] 96 7e-20
gi|54633319 PDZ domain-containing guanine nucleotide exchange fa... 94 4e-19
gi|224586880 Ras protein-specific guanine nucleotide-releasing f... 84 3e-16
gi|24797099 Ras protein-specific guanine nucleotide-releasing fa... 84 3e-16
gi|24797101 Ras protein-specific guanine nucleotide-releasing fa... 84 3e-16
gi|93102367 ral guanine nucleotide dissociation stimulator-like ... 81 2e-15
gi|38505170 Ras protein-specific guanine nucleotide-releasing fa... 79 1e-14
gi|213385270 RAS guanyl releasing protein 3 (calcium and DAG-reg... 74 4e-13
gi|24762239 RAS guanyl releasing protein 3 (calcium and DAG-regu... 74 4e-13
gi|7662334 RAS guanyl releasing protein 3 (calcium and DAG-regul... 74 4e-13
gi|155030206 Rap guanine nucleotide exchange factor (GEF) 4 isof... 71 2e-12
gi|155030204 Rap guanine nucleotide exchange factor (GEF) 4 isof... 71 2e-12
gi|190684646 RAS guanyl releasing protein 1 isoform b [Homo sapi... 71 2e-12
gi|190684644 RAS guanyl releasing protein 1 isoform a [Homo sapi... 71 2e-12
gi|148747862 Rap guanine nucleotide exchange factor 3 isoform b ... 70 3e-12
gi|20070215 Rap guanine nucleotide exchange factor 3 isoform b [... 70 3e-12
gi|148747859 Rap guanine nucleotide exchange factor 3 isoform a ... 70 3e-12
gi|24797103 RAS guanyl releasing protein 2 [Homo sapiens] 70 4e-12
gi|149158729 RAS guanyl releasing protein 2 [Homo sapiens] 70 4e-12
gi|149158727 RAS guanyl releasing protein 2 [Homo sapiens] 70 4e-12
gi|26051258 RAS guanyl releasing protein 4 isoform a [Homo sapiens] 69 7e-12
gi|119392077 Rap guanine nucleotide exchange factor (GEF) 5 [Hom... 69 7e-12
gi|239582765 ral guanine nucleotide dissociation stimulator-like... 68 2e-11
gi|239582763 ral guanine nucleotide dissociation stimulator-like... 68 2e-11
gi|226246575 RAS guanyl releasing protein 4 isoform b [Homo sapi... 67 3e-11
gi|38373677 guanine nucleotide-releasing factor 2 isoform b [Hom... 66 8e-11
>gi|117168263 RasGEF domain family, member 1A [Homo sapiens]
Length = 481
Score = 974 bits (2519), Expect = 0.0
Identities = 481/481 (100%), Positives = 481/481 (100%)
Query: 1 MPQTSVVFSSILGPSCSGQVQPGMGERGGGAGGGSGDLIFQDGHLISGSLEALMEHLVPT 60
MPQTSVVFSSILGPSCSGQVQPGMGERGGGAGGGSGDLIFQDGHLISGSLEALMEHLVPT
Sbjct: 1 MPQTSVVFSSILGPSCSGQVQPGMGERGGGAGGGSGDLIFQDGHLISGSLEALMEHLVPT 60
Query: 61 VDYYPDRTYIFTFLLSSRVFMPPHDLLARVGQICVEQKQQLEAGPEKAKLKSFSAKIVQL 120
VDYYPDRTYIFTFLLSSRVFMPPHDLLARVGQICVEQKQQLEAGPEKAKLKSFSAKIVQL
Sbjct: 61 VDYYPDRTYIFTFLLSSRVFMPPHDLLARVGQICVEQKQQLEAGPEKAKLKSFSAKIVQL 120
Query: 121 LKEWTEAFPYDFQDEKAMAELKAITHRVTQCDEENGTVKKAIAQMTQSLLLSLAARSQLQ 180
LKEWTEAFPYDFQDEKAMAELKAITHRVTQCDEENGTVKKAIAQMTQSLLLSLAARSQLQ
Sbjct: 121 LKEWTEAFPYDFQDEKAMAELKAITHRVTQCDEENGTVKKAIAQMTQSLLLSLAARSQLQ 180
Query: 181 ELREKLRPPAVDKGPILKTKPPAAQKDILGVCCDPLVLAQQLTHIELDRVSSIYPEDLMQ 240
ELREKLRPPAVDKGPILKTKPPAAQKDILGVCCDPLVLAQQLTHIELDRVSSIYPEDLMQ
Sbjct: 181 ELREKLRPPAVDKGPILKTKPPAAQKDILGVCCDPLVLAQQLTHIELDRVSSIYPEDLMQ 240
Query: 241 IVSHMDSLDNHRCRGDLTKTYSLEAYDNWFNCLSMLVATEVCRVVKKKHRTRMLEFFIDV 300
IVSHMDSLDNHRCRGDLTKTYSLEAYDNWFNCLSMLVATEVCRVVKKKHRTRMLEFFIDV
Sbjct: 241 IVSHMDSLDNHRCRGDLTKTYSLEAYDNWFNCLSMLVATEVCRVVKKKHRTRMLEFFIDV 300
Query: 301 ARECFNIGNFNSMMAIISGMNLSPVARLKKTWSKVKTAKFDVLEHHMDPSSNFCNYRTAL 360
ARECFNIGNFNSMMAIISGMNLSPVARLKKTWSKVKTAKFDVLEHHMDPSSNFCNYRTAL
Sbjct: 301 ARECFNIGNFNSMMAIISGMNLSPVARLKKTWSKVKTAKFDVLEHHMDPSSNFCNYRTAL 360
Query: 361 QGATQRSQMANSSREKIVIPVFNLFVKDIYFLHKIHTNHLPNGHINFKKFWEISRQIHEF 420
QGATQRSQMANSSREKIVIPVFNLFVKDIYFLHKIHTNHLPNGHINFKKFWEISRQIHEF
Sbjct: 361 QGATQRSQMANSSREKIVIPVFNLFVKDIYFLHKIHTNHLPNGHINFKKFWEISRQIHEF 420
Query: 421 MTWTQVECPFEKDKKIQSYLLTAPIYSEEALFVASFESEGPENHMEKDSWKTLRTTLLNR 480
MTWTQVECPFEKDKKIQSYLLTAPIYSEEALFVASFESEGPENHMEKDSWKTLRTTLLNR
Sbjct: 421 MTWTQVECPFEKDKKIQSYLLTAPIYSEEALFVASFESEGPENHMEKDSWKTLRTTLLNR 480
Query: 481 A 481
A
Sbjct: 481 A 481
>gi|22749129 RasGEF domain family, member 1B [Homo sapiens]
Length = 473
Score = 570 bits (1470), Expect = e-163
Identities = 274/446 (61%), Positives = 352/446 (78%), Gaps = 3/446 (0%)
Query: 36 GDLIFQDGHLISGSLEALMEHLVPTVDYYPDRTYIFTFLLSSRVFMPPHDLLARVGQICV 95
G L + D +L+SGSLEAL++HLVP VDYYPDRTYIFTFLLSSR+FM P++L+A+V +CV
Sbjct: 29 GGLYYHDNNLLSGSLEALIQHLVPNVDYYPDRTYIFTFLLSSRLFMHPYELMAKVCHLCV 88
Query: 96 EQKQQLEAGPEKAKLKSFSAKIVQLLKEWTEAFPYDFQDEKAMAELKAITHRVTQCDEEN 155
E ++ + +K +++ + KI+QLL EWTE FPYDF+DE+ M LK + HR+ +E+
Sbjct: 89 EHQRLSDPDSDKNQMRKIAPKILQLLTEWTETFPYDFRDERMMRNLKDLAHRIASGEEQ- 147
Query: 156 GTVKKAIAQMTQSLLLSLAARSQLQELREKLRPPAVDKGPILKTKPPAAQKDILGVCCDP 215
T +K + QM Q L+ LAA SQ +E+ K+ + D+ +LKTKP + Q+DI+ VC DP
Sbjct: 148 -TYRKNVQQMMQCLIRKLAALSQYEEVLAKISSTSTDRLTVLKTKPQSIQRDIITVCNDP 206
Query: 216 LVLAQQLTHIELDRVSSIYPEDLMQIVSHMDSLDNHR-CRGDLTKTYSLEAYDNWFNCLS 274
LAQQLTHIEL+R++ I PE+ +Q D LDN + C + KT +LEAY WFN LS
Sbjct: 207 YTLAQQLTHIELERLNYIGPEEFVQAFVQKDPLDNDKSCYSERKKTRNLEAYVEWFNRLS 266
Query: 275 MLVATEVCRVVKKKHRTRMLEFFIDVARECFNIGNFNSMMAIISGMNLSPVARLKKTWSK 334
LVATE+C VKKKHR RM+E+FIDVARECFNIGNFNS+MAIISGMN+SPV+RLKKTW+K
Sbjct: 267 YLVATEICMPVKKKHRARMIEYFIDVARECFNIGNFNSLMAIISGMNMSPVSRLKKTWAK 326
Query: 335 VKTAKFDVLEHHMDPSSNFCNYRTALQGATQRSQMANSSREKIVIPVFNLFVKDIYFLHK 394
VKTAKFD+LEH MDPSSNF NYRTAL+GA QRS A+SSREKIVIP F+L +KDIYFL++
Sbjct: 327 VKTAKFDILEHQMDPSSNFYNYRTALRGAAQRSLTAHSSREKIVIPFFSLLIKDIYFLNE 386
Query: 395 IHTNHLPNGHINFKKFWEISRQIHEFMTWTQVECPFEKDKKIQSYLLTAPIYSEEALFVA 454
N LPNGH+NF+KFWE+++Q+ EFMTW QVECPFE+D+KI YLLT P++SE+AL++A
Sbjct: 387 GCANRLPNGHVNFEKFWELAKQVSEFMTWKQVECPFERDRKILQYLLTVPVFSEDALYLA 446
Query: 455 SFESEGPENHMEKDSWKTLRTTLLNR 480
S+ESEGPENH+EKD WK+LR++LL R
Sbjct: 447 SYESEGPENHIEKDRWKSLRSSLLGR 472
>gi|40255197 RasGEF domain family, member 1C [Homo sapiens]
Length = 466
Score = 491 bits (1263), Expect = e-139
Identities = 259/482 (53%), Positives = 337/482 (69%), Gaps = 19/482 (3%)
Query: 1 MPQTSVVFSSILGPSCSGQVQPGMGERGGGAGGGSGDLIFQDGHLISGSLEALMEHLVPT 60
MPQT + S ++ P G + P E G G L DG S SLE L++HLVPT
Sbjct: 1 MPQT-LSASDMVTP---GSLSPPPTEPTDGEQAGQPLL---DGAPSSASLETLIQHLVPT 53
Query: 61 VDYYPDRTYIFTFLLSSRVFMPPHDLLARVGQICVEQKQQLEAGPEKAKLKSFSAKIVQL 120
DYYP++ YIFTFLLSSR+F+ P +LLARV +C+EQ+Q + +KA+++ F K++QL
Sbjct: 54 ADYYPEKAYIFTFLLSSRLFIEPRELLARVCHLCIEQQQLDKPVLDKARVRKFGPKLLQL 113
Query: 121 LKEWTEAFPYDFQDEKAMAELKAITHRVTQCDEENGTVKKAIAQMTQSLLLSLAARSQLQ 180
L EWTE FP DFQ+E + LK + R+ CDE +K + Q+ Q+L LAA Q
Sbjct: 114 LAEWTETFPRDFQEESTIGHLKDVVGRIAPCDE---AYRKRMHQLLQALHQKLAALRQGP 170
Query: 181 ELREKLRPPAVDKGPILKTKPPAA-QKDILGVCCDPLVLAQQLTHIELDRVSSIYPEDLM 239
E DK +TKPPA+ +++LGVC DP LAQQLTH+EL+R+ I PE+ +
Sbjct: 171 E-----GLVGADKPISYRTKPPASIHRELLGVCSDPYTLAQQLTHVELERLRHIGPEEFV 225
Query: 240 QIVSHMDSLDNHR-CRGDLTKTYSLEAYDNWFNCLSMLVATEVCRVVKKKHRTRMLEFFI 298
Q + D L + + C D KT +LEAY WFN L LVATE+C KKK R +++EFFI
Sbjct: 226 QAFVNKDPLASTKPCFSD--KTSNLEAYVKWFNRLCYLVATEICMPAKKKQRAQVIEFFI 283
Query: 299 DVARECFNIGNFNSMMAIISGMNLSPVARLKKTWSKVKTAKFDVLEHHMDPSSNFCNYRT 358
DVARECFNIGNFNS+MAIISGMN+SPV+RLKKTW+KV+TAKF +LEH MDP+ NFCNYRT
Sbjct: 284 DVARECFNIGNFNSLMAIISGMNMSPVSRLKKTWAKVRTAKFFILEHQMDPTGNFCNYRT 343
Query: 359 ALQGATQRSQMANSSREKIVIPVFNLFVKDIYFLHKIHTNHLPNGHINFKKFWEISRQIH 418
AL+GA RS A+SSREKIVIP F+L +KDIYFL++ N LPNGH+NF+KF E+++Q+
Sbjct: 344 ALRGAAHRSLTAHSSREKIVIPFFSLLIKDIYFLNEGCANRLPNGHVNFEKFLELAKQVG 403
Query: 419 EFMTWTQVECPFEKDKKIQSYLLTAPIYSEEALFVASFESEGPENHMEKDSWKTLRTTLL 478
EF+TW QVECPFE+D I YL TAPI+SE+ L++AS+ESE PEN EK+ WK LR+++L
Sbjct: 404 EFITWKQVECPFEQDASITHYLYTAPIFSEDGLYLASYESESPENQTEKERWKALRSSIL 463
Query: 479 NR 480
+
Sbjct: 464 GK 465
>gi|4758532 ral guanine nucleotide dissociation stimulator-like 2
[Homo sapiens]
Length = 777
Score = 97.1 bits (240), Expect = 3e-20
Identities = 118/464 (25%), Positives = 191/464 (41%), Gaps = 56/464 (12%)
Query: 45 LISGSLEALMEHLVPTVDYYPDRTYIFTFLLSSRVFMPPHDLLARVGQICVEQKQQLEAG 104
L +G+LEAL+ HL+ T D +++ FL + R F LL + ++ + LE+
Sbjct: 92 LRAGTLEALVRHLLDTRTSGTDVSFMSAFLATHRAFTSTPALLG----LMADRLEALESH 147
Query: 105 PEKAKLKSFSAKIVQLLKEWTEAFPYDFQDEKAMAELKAITHRVTQCDEENGTVKKAIAQ 164
P +L+ + + +L W + P DF E A +L + + Q G K +
Sbjct: 148 PTD-ELERTTEVAISVLSTWLASHPEDFGSE-AKGQLDRLESFLLQTGYAAG---KGVGG 202
Query: 165 MTQSLLLSLAARSQLQELREKLRPPAVDKGPILKTKPPAAQKDILGVCCDPLVLAQQLTH 224
+ L+ +L +R Q P + K L PPA D+L D L A+QLT
Sbjct: 203 GSADLIRNLRSRVDPQA-------PDLPKPLALPGDPPADPTDVLVFLADHL--AEQLTL 253
Query: 225 IELDRVSSIYPEDLMQIVSHMDSLDNHRCR-GDLTKTYSLEAYDNWFNCLSMLVATEVC- 282
++ + ++ P + L HR R G S+ A FN ++ V + V
Sbjct: 254 LDAELFLNLIPSQCL------GGLWGHRDRPGHSHLCPSVRATVTQFNKVAGAVVSSVLG 307
Query: 283 -------------RVVKKKHRTRMLEFFIDVARECFNIGNFNSMMAIISGMNLSPVARLK 329
R ++ R R+LE +I VA EC + NF+S+ A++S + SP+ RL+
Sbjct: 308 ATSTGEGPGEVTIRPLRPPQRARLLEKWIRVAEECRLLRNFSSVYAVVSALQSSPIHRLR 367
Query: 330 KTWSKVKTAKFDVLEHHMDPSSNFCNYRTALQGATQRSQM------------ANSSREKI 377
W + V S NY + + Q ++ + SR
Sbjct: 368 AAWGEATRDSLRVFSSLCQIFSEEDNYSQSRELLVQEVKLQSPLEPHSKKAPRSGSRGGG 427
Query: 378 VIPVFNLFVKDIYFLHKIHTNHLPNGHINFKKFWEISRQIHEFMTWTQVEC---PFEKDK 434
V+P F+KD+ L + L NG+INF K + + E + Q EC + D
Sbjct: 428 VVPYLGTFLKDLVMLDAASKDELENGYINFDKRRKEFAVLSE-LRRLQNECRGYNLQPDH 486
Query: 435 KIQSYLLTAPIYSEEALFVASFESEGPENHMEKDSWKTLRTTLL 478
IQ +L +E S E E P + + + LR TL+
Sbjct: 487 DIQRWLQGLRPLTEAQSHRVSCEVE-PPGSSDPPAPRVLRPTLV 529
>gi|7657261 Rap guanine nucleotide exchange factor 2 [Homo sapiens]
Length = 1499
Score = 95.9 bits (237), Expect = 7e-20
Identities = 63/224 (28%), Positives = 116/224 (51%), Gaps = 13/224 (5%)
Query: 197 LKTKPPAAQKDILGVCCDPLVLAQQLTHIELDRVSSIYPEDLMQIVSHMDSLDNHRCRGD 256
++T+ + +D + + + QL+ +E+ S+ +L + + + +D+
Sbjct: 691 METETLCSDEDAQELLRESQISLLQLSTVEVATQLSMRNFELFRNIEPTEYIDDLFKLRS 750
Query: 257 LTKTYSLEAYDNWFNCLSMLVATEVCRVVKKKHRTRMLEFFIDVARECFNIGNFNSMMAI 316
T +L+ ++ N + VA+E+ R + R ++++ FI +A C NFNSM AI
Sbjct: 751 KTSCANLKRFEEVINQETFWVASEILRETNQLKRMKIIKHFIKIALHCRECKNFNSMFAI 810
Query: 317 ISGMNLSPVARLKKTWSKVKT---AKFDVLEHHMDPSSNFCNYRTALQGATQRSQMANSS 373
ISG+NL+PVARL+ TW K+ F L+ DPS N YR L + +
Sbjct: 811 ISGLNLAPVARLRTTWEKLPNKYEKLFQDLQDLFDPSRNMAKYRNVLN---------SQN 861
Query: 374 REKIVIPVFNLFVKDIYFLHKIHTNHLPNGHINFKKFWEISRQI 417
+ +IP+F + KD+ FLH+ + + + +G +NF+K I+++I
Sbjct: 862 LQPPIIPLFPVIKKDLTFLHEGNDSKV-DGLVNFEKLRMIAKEI 904
>gi|54633319 PDZ domain-containing guanine nucleotide exchange factor
I [Homo sapiens]
Length = 1601
Score = 93.6 bits (231), Expect = 4e-19
Identities = 63/207 (30%), Positives = 108/207 (52%), Gaps = 13/207 (6%)
Query: 221 QLTHIELDRVSSIYPEDLMQIVSHMDSLDNHRCRGDLTKTYSLEAYDNWFNCLSMLVATE 280
QL+ IE+ S+ DL + + + +D+ T L+ +++ N + VA+E
Sbjct: 858 QLSTIEVATQLSMRDFDLFRNIEPTEYIDDLFKLNSKTGNTHLKRFEDIVNQETFWVASE 917
Query: 281 VCRVVKKKHRTRMLEFFIDVARECFNIGNFNSMMAIISGMNLSPVARLKKTWSKVKT--- 337
+ + R ++++ FI +A C NFNSM AIISG+NL+ VARL+ TW K+ +
Sbjct: 918 ILTEANQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLASVARLRGTWEKLPSKYE 977
Query: 338 AKFDVLEHHMDPSSNFCNYRTALQGATQRSQMANSSREKIVIPVFNLFVKDIYFLHKIHT 397
L+ DPS N YR L ++ S + +IP+F + KD+ FLH+ +
Sbjct: 978 KHLQDLQDIFDPSRNMAKYRNIL---------SSQSMQPPIIPLFPVVKKDMTFLHEGND 1028
Query: 398 NHLPNGHINFKKFWEISRQIHEFMTWT 424
+ + +G +NF+K IS++I + + T
Sbjct: 1029 SKV-DGLVNFEKLRMISKEIRQVVRMT 1054
>gi|224586880 Ras protein-specific guanine nucleotide-releasing factor
1 isoform 3 [Homo sapiens]
Length = 1257
Score = 84.0 bits (206), Expect = 3e-16
Identities = 58/194 (29%), Positives = 91/194 (46%), Gaps = 15/194 (7%)
Query: 270 FNCLSMLVATEVCRVVKKKHRTRMLEFFIDVARECFNIGNFNSMMAIISGMNLSPVARLK 329
FN +S L+A+E+ R R +E ++ VA C + N+N+++ I S MN S + RLK
Sbjct: 1070 FNDISNLIASEIIRNEDINARVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRLK 1129
Query: 330 KTWSKVK---TAKFDVLEHHMDPSSNFCNYRTALQGATQRSQMANSSREKIVIPVFNLFV 386
KTW KV A D L+ + F N R AL+ + +P +++
Sbjct: 1130 KTWLKVSKQTKALIDKLQKLVSSEGRFKNLREALKNC-----------DPPCVPYLGMYL 1178
Query: 387 KDIYFLHKIHTNHLPNGHINFKKFWEISRQIHEFMTWTQVECPFEKDKKIQSYLLTAP-I 445
D+ F+ + N+ +G +NF K IS I E + Q E K+ YLL +
Sbjct: 1179 TDLAFIEEGTPNYTEDGLVNFSKMRMISHIIREIRQFQQTAYKIEHQAKVTQYLLDQSFV 1238
Query: 446 YSEEALFVASFESE 459
EE+L+ +S E
Sbjct: 1239 MDEESLYESSLRIE 1252
>gi|24797099 Ras protein-specific guanine nucleotide-releasing factor
1 isoform 1 [Homo sapiens]
Length = 1273
Score = 84.0 bits (206), Expect = 3e-16
Identities = 58/194 (29%), Positives = 91/194 (46%), Gaps = 15/194 (7%)
Query: 270 FNCLSMLVATEVCRVVKKKHRTRMLEFFIDVARECFNIGNFNSMMAIISGMNLSPVARLK 329
FN +S L+A+E+ R R +E ++ VA C + N+N+++ I S MN S + RLK
Sbjct: 1086 FNDISNLIASEIIRNEDINARVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRLK 1145
Query: 330 KTWSKVK---TAKFDVLEHHMDPSSNFCNYRTALQGATQRSQMANSSREKIVIPVFNLFV 386
KTW KV A D L+ + F N R AL+ + +P +++
Sbjct: 1146 KTWLKVSKQTKALIDKLQKLVSSEGRFKNLREALKNC-----------DPPCVPYLGMYL 1194
Query: 387 KDIYFLHKIHTNHLPNGHINFKKFWEISRQIHEFMTWTQVECPFEKDKKIQSYLLTAP-I 445
D+ F+ + N+ +G +NF K IS I E + Q E K+ YLL +
Sbjct: 1195 TDLAFIEEGTPNYTEDGLVNFSKMRMISHIIREIRQFQQTAYKIEHQAKVTQYLLDQSFV 1254
Query: 446 YSEEALFVASFESE 459
EE+L+ +S E
Sbjct: 1255 MDEESLYESSLRIE 1268
>gi|24797101 Ras protein-specific guanine nucleotide-releasing
factor 1 isoform 2 [Homo sapiens]
Length = 489
Score = 84.0 bits (206), Expect = 3e-16
Identities = 58/194 (29%), Positives = 91/194 (46%), Gaps = 15/194 (7%)
Query: 270 FNCLSMLVATEVCRVVKKKHRTRMLEFFIDVARECFNIGNFNSMMAIISGMNLSPVARLK 329
FN +S L+A+E+ R R +E ++ VA C + N+N+++ I S MN S + RLK
Sbjct: 302 FNDISNLIASEIIRNEDINARVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRLK 361
Query: 330 KTWSKVK---TAKFDVLEHHMDPSSNFCNYRTALQGATQRSQMANSSREKIVIPVFNLFV 386
KTW KV A D L+ + F N R AL+ + +P +++
Sbjct: 362 KTWLKVSKQTKALIDKLQKLVSSEGRFKNLREALKNC-----------DPPCVPYLGMYL 410
Query: 387 KDIYFLHKIHTNHLPNGHINFKKFWEISRQIHEFMTWTQVECPFEKDKKIQSYLLTAP-I 445
D+ F+ + N+ +G +NF K IS I E + Q E K+ YLL +
Sbjct: 411 TDLAFIEEGTPNYTEDGLVNFSKMRMISHIIREIRQFQQTAYKIEHQAKVTQYLLDQSFV 470
Query: 446 YSEEALFVASFESE 459
EE+L+ +S E
Sbjct: 471 MDEESLYESSLRIE 484
>gi|93102367 ral guanine nucleotide dissociation stimulator-like 1
[Homo sapiens]
Length = 803
Score = 81.3 bits (199), Expect = 2e-15
Identities = 102/450 (22%), Positives = 190/450 (42%), Gaps = 58/450 (12%)
Query: 47 SGSLEALMEHLVPTVDYYPDRTYIFTFLLSSRVFMPPHD----LLARVGQI----CVEQK 98
+G+LE L+E+L+ T D TYI FL + R F + LL R G + C E
Sbjct: 106 AGTLEKLVENLL-TAFGDNDFTYISIFLSTYRGFASTKEVLELLLDRYGNLTSPNCEEDG 164
Query: 99 QQLEAGPEKAKLKSFSAKIVQLLKEWTEAFPYDFQDEKAMAELKAITHRVTQCDEENGTV 158
Q + ++K+ +A I +L+ W + DF++ L+ + +T+ +
Sbjct: 165 SQSSS---ESKMVIRNA-IASILRAWLDQCAEDFREPPHFPCLQKLLDYLTRMMPGSDPE 220
Query: 159 KKAIAQMTQSLLLSLAARSQLQELREKLRPPAVDKGPILKTKPPAAQKDILGVCCDPLVL 218
++A Q+LL + Q QE+ P + + + + C ++
Sbjct: 221 RRA-----QNLL----EQFQKQEVETDNGLPNTISFSLEEEEELEGGESAEFTCFSEDLV 271
Query: 219 AQQLTHIELDRVSSIYPEDLMQIV-SHMDSLDNHRCRGDLTKTYSLEAYDNWFNCLSMLV 277
A+QLT+++ + P + + S D +N + T S FN L+ V
Sbjct: 272 AEQLTYMDAQLFKKVVPHHCLGCIWSRRDKKENKHLAPTIRATISQ------FNTLTKCV 325
Query: 278 ATEVC--RVVKKKHRTRMLEFFIDVARECFNIGNFNSMMAIISGMNLSPVARLKKTWSKV 335
+ + + +K + R +++E +I++A EC + NF+S+ AI+S + + + RLKKTW+ V
Sbjct: 326 VSTILGGKELKTQQRAKIIEKWINIAHECRLLKNFSSLRAIVSALQSNSIYRLKKTWAAV 385
Query: 336 KTAKFDVLEHHMDPSSNFCNYRTA--------------LQGATQRSQMANSSREKI---- 377
+ + E D S+ N+ T+ L + + +Q R ++
Sbjct: 386 PRDRMLMFEELSDIFSDHNNHLTSRELLMKEGTSKFANLDSSVKENQKRTQRRLQLQKDM 445
Query: 378 -----VIPVFNLFVKDIYFLHKIHTNHLPNGHINFKK---FWEISRQIHEFMTWTQVECP 429
+P F+ D+ L +++ G INF+K +E+ QI + C
Sbjct: 446 GVMQGTVPYLGTFLTDLTMLDTALQDYIEGGLINFEKRRREFEVIAQIKLLQSACNSYC- 504
Query: 430 FEKDKKIQSYLLTAPIYSEEALFVASFESE 459
D+K + + +EE + S E E
Sbjct: 505 MTPDQKFIQWFQRQQLLTEEESYALSCEIE 534
>gi|38505170 Ras protein-specific guanine nucleotide-releasing factor
2 [Homo sapiens]
Length = 1237
Score = 78.6 bits (192), Expect = 1e-14
Identities = 54/194 (27%), Positives = 86/194 (44%), Gaps = 15/194 (7%)
Query: 270 FNCLSMLVATEVCRVVKKKHRTRMLEFFIDVARECFNIGNFNSMMAIISGMNLSPVARLK 329
FN +S LVA+++ R +E ++ VA C + N+N ++ I S +N S + RLK
Sbjct: 1050 FNDMSNLVASQIMNYADVSSRANAIEKWVAVADICRCLHNYNGVLEITSALNRSAIYRLK 1109
Query: 330 KTWSKVK---TAKFDVLEHHMDPSSNFCNYRTALQGATQRSQMANSSREKIVIPVFNLFV 386
KTW+KV A D L+ + F N R L+ + +P +++
Sbjct: 1110 KTWAKVSKQTKALMDKLQKTVSSEGRFKNLRETLKNCNPPA-----------VPYLGMYL 1158
Query: 387 KDIYFLHKIHTNHLPNGHINFKKFWEISRQIHEFMTWTQVECPFEKDKKIQSYLLTAP-I 445
D+ F+ + N G +NF K IS I E + Q + K+ YLL I
Sbjct: 1159 TDLAFIEEGTPNFTEEGLVNFSKMRMISHIIREIRQFQQTSYRIDHQPKVAQYLLDKDLI 1218
Query: 446 YSEEALFVASFESE 459
E+ L+ S + E
Sbjct: 1219 IDEDTLYELSLKIE 1232
>gi|213385270 RAS guanyl releasing protein 3 (calcium and
DAG-regulated) isoform 1 [Homo sapiens]
Length = 690
Score = 73.6 bits (179), Expect = 4e-13
Identities = 58/240 (24%), Positives = 106/240 (44%), Gaps = 25/240 (10%)
Query: 214 DPLVLAQQLTHIELDRVSSIYPEDLMQIVSHMDSLDNHRCRGDLTKTYSLEAYDNWFNCL 273
+P+ LA+ LT +E I D V H G L +LE FN +
Sbjct: 152 EPIELAEHLTFLEHKSFRRISFTDYQSYVIH----------GCLENNPTLERSIALFNGI 201
Query: 274 SMLVATEVCRVVKKKHRTRMLEFFIDVARECFNIGNFNSMMAIISGMNLSPVARLKKTWS 333
S V V + R ++ FI+VA++ + NFN++MA++ G++ S ++RLK+T S
Sbjct: 202 SKWVQLMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNTLMAVVGGLSHSSISRLKETHS 261
Query: 334 KVK---TAKFDVLEHHMDPSSNFCNYRTALQGATQRSQMANSSREKIVIPVFNLFVKDIY 390
+ T ++ + + + N+CNYR A + + IP+ + +KD+
Sbjct: 262 HLSSEVTKNWNEMTELVSSNGNYCNYRKAF-----------ADCDGFKIPILGVHLKDLI 310
Query: 391 FLHKIHTNHLPNGHINFKKFWEISRQIHEFMTWTQVECPFEKDKKIQSYL-LTAPIYSEE 449
+H I + +N K ++S + E ++ E + + + L L+ +Y E
Sbjct: 311 AVHVIFPDWTEENKVNIVKMHQLSVTLSELVSLQNASHHLEPNMDLINLLTLSLDLYHTE 370
>gi|24762239 RAS guanyl releasing protein 3 (calcium and
DAG-regulated) isoform 1 [Homo sapiens]
Length = 690
Score = 73.6 bits (179), Expect = 4e-13
Identities = 58/240 (24%), Positives = 106/240 (44%), Gaps = 25/240 (10%)
Query: 214 DPLVLAQQLTHIELDRVSSIYPEDLMQIVSHMDSLDNHRCRGDLTKTYSLEAYDNWFNCL 273
+P+ LA+ LT +E I D V H G L +LE FN +
Sbjct: 152 EPIELAEHLTFLEHKSFRRISFTDYQSYVIH----------GCLENNPTLERSIALFNGI 201
Query: 274 SMLVATEVCRVVKKKHRTRMLEFFIDVARECFNIGNFNSMMAIISGMNLSPVARLKKTWS 333
S V V + R ++ FI+VA++ + NFN++MA++ G++ S ++RLK+T S
Sbjct: 202 SKWVQLMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNTLMAVVGGLSHSSISRLKETHS 261
Query: 334 KVK---TAKFDVLEHHMDPSSNFCNYRTALQGATQRSQMANSSREKIVIPVFNLFVKDIY 390
+ T ++ + + + N+CNYR A + + IP+ + +KD+
Sbjct: 262 HLSSEVTKNWNEMTELVSSNGNYCNYRKAF-----------ADCDGFKIPILGVHLKDLI 310
Query: 391 FLHKIHTNHLPNGHINFKKFWEISRQIHEFMTWTQVECPFEKDKKIQSYL-LTAPIYSEE 449
+H I + +N K ++S + E ++ E + + + L L+ +Y E
Sbjct: 311 AVHVIFPDWTEENKVNIVKMHQLSVTLSELVSLQNASHHLEPNMDLINLLTLSLDLYHTE 370
>gi|7662334 RAS guanyl releasing protein 3 (calcium and
DAG-regulated) isoform 2 [Homo sapiens]
Length = 689
Score = 73.6 bits (179), Expect = 4e-13
Identities = 58/240 (24%), Positives = 106/240 (44%), Gaps = 25/240 (10%)
Query: 214 DPLVLAQQLTHIELDRVSSIYPEDLMQIVSHMDSLDNHRCRGDLTKTYSLEAYDNWFNCL 273
+P+ LA+ LT +E I D V H G L +LE FN +
Sbjct: 152 EPIELAEHLTFLEHKSFRRISFTDYQSYVIH----------GCLENNPTLERSIALFNGI 201
Query: 274 SMLVATEVCRVVKKKHRTRMLEFFIDVARECFNIGNFNSMMAIISGMNLSPVARLKKTWS 333
S V V + R ++ FI+VA++ + NFN++MA++ G++ S ++RLK+T S
Sbjct: 202 SKWVQLMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNTLMAVVGGLSHSSISRLKETHS 261
Query: 334 KVK---TAKFDVLEHHMDPSSNFCNYRTALQGATQRSQMANSSREKIVIPVFNLFVKDIY 390
+ T ++ + + + N+CNYR A + + IP+ + +KD+
Sbjct: 262 HLSSEVTKNWNEMTELVSSNGNYCNYRKAF-----------ADCDGFKIPILGVHLKDLI 310
Query: 391 FLHKIHTNHLPNGHINFKKFWEISRQIHEFMTWTQVECPFEKDKKIQSYL-LTAPIYSEE 449
+H I + +N K ++S + E ++ E + + + L L+ +Y E
Sbjct: 311 AVHVIFPDWTEENKVNIVKMHQLSVTLSELVSLQNASHHLEPNMDLINLLTLSLDLYHTE 370
>gi|155030206 Rap guanine nucleotide exchange factor (GEF) 4 isoform
b [Homo sapiens]
Length = 867
Score = 71.2 bits (173), Expect = 2e-12
Identities = 55/182 (30%), Positives = 87/182 (47%), Gaps = 16/182 (8%)
Query: 232 SIYPEDLMQIVSHMDSLDNHRCRGDLTKTYS-LEAYDNWFNCLSMLVATEVCRVVKKKHR 290
+IY +L V ++ + + R + KT + L+ + FN + V TE+C + R
Sbjct: 637 TIYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWVVTEICLCSQLSKR 696
Query: 291 TRMLEFFIDVARECFNIGNFNSMMAIISGMNLSPVARLKKTWSKV--KTAKFDV-LEHHM 347
++L+ FI +A C N NS AI+ G++ V+RL TW K+ K KF E M
Sbjct: 697 VQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLM 756
Query: 348 DPSSNFCNYRTALQGATQRSQMANSSREKIVIPVFNLFVKDIYFLHKIHTNHLPNGHINF 407
DPS N YR + + E +IP L +KD+ F H+ + + N +NF
Sbjct: 757 DPSRNHRAYRLTV-----------AKLEPPLIPFMPLLIKDMTFTHEGNKTFIDN-LVNF 804
Query: 408 KK 409
+K
Sbjct: 805 EK 806
>gi|155030204 Rap guanine nucleotide exchange factor (GEF) 4 isoform
a [Homo sapiens]
Length = 1011
Score = 71.2 bits (173), Expect = 2e-12
Identities = 55/182 (30%), Positives = 87/182 (47%), Gaps = 16/182 (8%)
Query: 232 SIYPEDLMQIVSHMDSLDNHRCRGDLTKTYS-LEAYDNWFNCLSMLVATEVCRVVKKKHR 290
+IY +L V ++ + + R + KT + L+ + FN + V TE+C + R
Sbjct: 781 TIYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWVVTEICLCSQLSKR 840
Query: 291 TRMLEFFIDVARECFNIGNFNSMMAIISGMNLSPVARLKKTWSKV--KTAKFDV-LEHHM 347
++L+ FI +A C N NS AI+ G++ V+RL TW K+ K KF E M
Sbjct: 841 VQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLM 900
Query: 348 DPSSNFCNYRTALQGATQRSQMANSSREKIVIPVFNLFVKDIYFLHKIHTNHLPNGHINF 407
DPS N YR + + E +IP L +KD+ F H+ + + N +NF
Sbjct: 901 DPSRNHRAYRLTV-----------AKLEPPLIPFMPLLIKDMTFTHEGNKTFIDN-LVNF 948
Query: 408 KK 409
+K
Sbjct: 949 EK 950
>gi|190684646 RAS guanyl releasing protein 1 isoform b [Homo
sapiens]
Length = 762
Score = 71.2 bits (173), Expect = 2e-12
Identities = 67/264 (25%), Positives = 115/264 (43%), Gaps = 29/264 (10%)
Query: 214 DPLVLAQQLTHIELDRVSSIYPEDLMQIVSHMDSLDNHRCRGDLTKTYSLEAYDNWFNCL 273
+P L++ LT++E I D N+ + + ++E N +
Sbjct: 205 EPEELSEHLTYLEFKSFRRISFSDYQ----------NYLVNSCVKENPTMERSIALCNGI 254
Query: 274 SMLVATEVCRVVKKKHRTRMLEFFIDVARECFNIGNFNSMMAIISGMNLSPVARLKKTWS 333
S V V + R + FI VA++ + NFN++MA+I G+ S ++RLK+T S
Sbjct: 255 SQWVQLMVLSRPTPQLRAEVFIKFIQVAQKLHQLQNFNTLMAVIGGLCHSSISRLKETSS 314
Query: 334 KVKTAKFDVL---EHHMDPSSNFCNYRTALQGATQRSQMANSSREKIVIPVFNLFVKDIY 390
V VL + S N+ NYR A T IP+ + +KD+
Sbjct: 315 HVPHEINKVLGEMTELLSSSRNYDNYRRAYGECTD-----------FKIPILGVHLKDLI 363
Query: 391 FLHKIHTNHLPNGHINFKKFWEISRQIHEFMTWTQVECPFEKDKKIQSYLLTAPI---YS 447
L++ ++L +G +N K + I E + +V P E +K + +LLT + Y+
Sbjct: 364 SLYEAMPDYLEDGKVNVHKLLALYNHISELVQLQEVAPPLEANKDL-VHLLTLSLDLYYT 422
Query: 448 EEALFVASFESEGPENHMEKDSWK 471
E+ ++ S+ E P NH +K
Sbjct: 423 EDEIYELSYARE-PRNHRAPSVFK 445
>gi|190684644 RAS guanyl releasing protein 1 isoform a [Homo
sapiens]
Length = 797
Score = 70.9 bits (172), Expect = 2e-12
Identities = 66/257 (25%), Positives = 113/257 (43%), Gaps = 29/257 (11%)
Query: 214 DPLVLAQQLTHIELDRVSSIYPEDLMQIVSHMDSLDNHRCRGDLTKTYSLEAYDNWFNCL 273
+P L++ LT++E I D N+ + + ++E N +
Sbjct: 205 EPEELSEHLTYLEFKSFRRISFSDYQ----------NYLVNSCVKENPTMERSIALCNGI 254
Query: 274 SMLVATEVCRVVKKKHRTRMLEFFIDVARECFNIGNFNSMMAIISGMNLSPVARLKKTWS 333
S V V + R + FI VA++ + NFN++MA+I G+ S ++RLK+T S
Sbjct: 255 SQWVQLMVLSRPTPQLRAEVFIKFIQVAQKLHQLQNFNTLMAVIGGLCHSSISRLKETSS 314
Query: 334 KVKTAKFDVL---EHHMDPSSNFCNYRTALQGATQRSQMANSSREKIVIPVFNLFVKDIY 390
V VL + S N+ NYR A T IP+ + +KD+
Sbjct: 315 HVPHEINKVLGEMTELLSSSRNYDNYRRAYGECTD-----------FKIPILGVHLKDLI 363
Query: 391 FLHKIHTNHLPNGHINFKKFWEISRQIHEFMTWTQVECPFEKDKKIQSYLLTAPI---YS 447
L++ ++L +G +N K + I E + +V P E +K + +LLT + Y+
Sbjct: 364 SLYEAMPDYLEDGKVNVHKLLALYNHISELVQLQEVAPPLEANKDL-VHLLTLSLDLYYT 422
Query: 448 EEALFVASFESEGPENH 464
E+ ++ S+ E P NH
Sbjct: 423 EDEIYELSYARE-PRNH 438
>gi|148747862 Rap guanine nucleotide exchange factor 3 isoform b
[Homo sapiens]
Length = 881
Score = 70.5 bits (171), Expect = 3e-12
Identities = 66/202 (32%), Positives = 96/202 (47%), Gaps = 24/202 (11%)
Query: 218 LAQQLTHIELDRVSSIYPEDLMQIVSHMDSLDNHRCRGDLTKTYSLEAYDNWFNCLSMLV 277
LA QLT + +SI+ +L+ V L D+T T +LE + FN L V
Sbjct: 624 LAGQLTDHDWSLFNSIHQVELIHYVLGPQHLR------DVT-TANLERFMRRFNELQYWV 676
Query: 278 ATEVCRVVKKKHRTRMLEFFIDVARECFNIGNFNSMMAIISGMNLSPVARLKKTWSKV-- 335
ATE+C R ++L FI +A N NS A++ G++ S ++RL TW ++
Sbjct: 677 ATELCLCPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFAVMFGLSNSAISRLAHTWERLPH 736
Query: 336 KTAK-FDVLEHHMDPSSNFCNYRTALQGATQRSQMANSSREKIVIPVFNLFVKDIYFLHK 394
K K + LE +DPS N YR AL + VIP L +KD+ F+H+
Sbjct: 737 KVRKLYSALERLLDPSWNHRVYRLAL-----------AKLSPPVIPFMPLLLKDMTFIHE 785
Query: 395 IHTNH-LPNGHINFKKFWEISR 415
NH L INF+K ++R
Sbjct: 786 --GNHTLVENLINFEKMRMMAR 805
Score = 30.0 bits (66), Expect = 4.9
Identities = 17/40 (42%), Positives = 23/40 (57%), Gaps = 1/40 (2%)
Query: 50 LEALMEHLVPTVDYY-PDRTYIFTFLLSSRVFMPPHDLLA 88
LE L+E + P + P T++ FLL+ RVFMP L A
Sbjct: 355 LELLLEAMGPDSSAHDPTETFLSDFLLTHRVFMPSAQLCA 394
>gi|20070215 Rap guanine nucleotide exchange factor 3 isoform b
[Homo sapiens]
Length = 881
Score = 70.5 bits (171), Expect = 3e-12
Identities = 66/202 (32%), Positives = 96/202 (47%), Gaps = 24/202 (11%)
Query: 218 LAQQLTHIELDRVSSIYPEDLMQIVSHMDSLDNHRCRGDLTKTYSLEAYDNWFNCLSMLV 277
LA QLT + +SI+ +L+ V L D+T T +LE + FN L V
Sbjct: 624 LAGQLTDHDWSLFNSIHQVELIHYVLGPQHLR------DVT-TANLERFMRRFNELQYWV 676
Query: 278 ATEVCRVVKKKHRTRMLEFFIDVARECFNIGNFNSMMAIISGMNLSPVARLKKTWSKV-- 335
ATE+C R ++L FI +A N NS A++ G++ S ++RL TW ++
Sbjct: 677 ATELCLCPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFAVMFGLSNSAISRLAHTWERLPH 736
Query: 336 KTAK-FDVLEHHMDPSSNFCNYRTALQGATQRSQMANSSREKIVIPVFNLFVKDIYFLHK 394
K K + LE +DPS N YR AL + VIP L +KD+ F+H+
Sbjct: 737 KVRKLYSALERLLDPSWNHRVYRLAL-----------AKLSPPVIPFMPLLLKDMTFIHE 785
Query: 395 IHTNH-LPNGHINFKKFWEISR 415
NH L INF+K ++R
Sbjct: 786 --GNHTLVENLINFEKMRMMAR 805
Score = 30.0 bits (66), Expect = 4.9
Identities = 17/40 (42%), Positives = 23/40 (57%), Gaps = 1/40 (2%)
Query: 50 LEALMEHLVPTVDYY-PDRTYIFTFLLSSRVFMPPHDLLA 88
LE L+E + P + P T++ FLL+ RVFMP L A
Sbjct: 355 LELLLEAMGPDSSAHDPTETFLSDFLLTHRVFMPSAQLCA 394
>gi|148747859 Rap guanine nucleotide exchange factor 3 isoform a
[Homo sapiens]
Length = 923
Score = 70.5 bits (171), Expect = 3e-12
Identities = 66/202 (32%), Positives = 96/202 (47%), Gaps = 24/202 (11%)
Query: 218 LAQQLTHIELDRVSSIYPEDLMQIVSHMDSLDNHRCRGDLTKTYSLEAYDNWFNCLSMLV 277
LA QLT + +SI+ +L+ V L D+T T +LE + FN L V
Sbjct: 666 LAGQLTDHDWSLFNSIHQVELIHYVLGPQHLR------DVT-TANLERFMRRFNELQYWV 718
Query: 278 ATEVCRVVKKKHRTRMLEFFIDVARECFNIGNFNSMMAIISGMNLSPVARLKKTWSKV-- 335
ATE+C R ++L FI +A N NS A++ G++ S ++RL TW ++
Sbjct: 719 ATELCLCPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFAVMFGLSNSAISRLAHTWERLPH 778
Query: 336 KTAK-FDVLEHHMDPSSNFCNYRTALQGATQRSQMANSSREKIVIPVFNLFVKDIYFLHK 394
K K + LE +DPS N YR AL + VIP L +KD+ F+H+
Sbjct: 779 KVRKLYSALERLLDPSWNHRVYRLAL-----------AKLSPPVIPFMPLLLKDMTFIHE 827
Query: 395 IHTNH-LPNGHINFKKFWEISR 415
NH L INF+K ++R
Sbjct: 828 --GNHTLVENLINFEKMRMMAR 847
Score = 30.0 bits (66), Expect = 4.9
Identities = 17/40 (42%), Positives = 23/40 (57%), Gaps = 1/40 (2%)
Query: 50 LEALMEHLVPTVDYY-PDRTYIFTFLLSSRVFMPPHDLLA 88
LE L+E + P + P T++ FLL+ RVFMP L A
Sbjct: 397 LELLLEAMGPDSSAHDPTETFLSDFLLTHRVFMPSAQLCA 436
>gi|24797103 RAS guanyl releasing protein 2 [Homo sapiens]
Length = 609
Score = 70.1 bits (170), Expect = 4e-12
Identities = 86/401 (21%), Positives = 160/401 (39%), Gaps = 54/401 (13%)
Query: 66 DRTYIFTFLLSSRVFMPPHDLLARVGQICVEQKQQLEAGPEKAKLKSFSAKIVQLLKEWT 125
D + FL+ ++P L A++ I + + K S K L++ W
Sbjct: 32 DPQLVRMFLMMHPWYIPSSQLAAKLLHIYQQSR--------KDNSNSLQVKTCHLVRYWI 83
Query: 126 EAFPYDFQDEKAMAELKAITHRVTQCDEENGTVKKAIAQMTQSLLLSLAARSQLQELREK 185
AFP +F +AE I D+E S L+ + + + R+
Sbjct: 84 SAFPAEFDLNPELAE--QIKELKALLDQEGNR--------RHSSLIDIDSVPTYKWKRQ- 132
Query: 186 LRPPAVDKGPILKTKPPAAQKDILGVCCDPLVLAQQLTHIELDRVSSIYPEDLMQIVSHM 245
+ P+ + K + +L +P+ LA+ LT++E I +D V+H
Sbjct: 133 ----VTQRNPVGQKK---RKMSLLFDHLEPMELAEHLTYLEYRSFCKILFQDYHSFVTHG 185
Query: 246 DSLDNHRCRGDLTKTYSLEAYDNWFNCLSMLVATEVCRVVKKKHRTRMLEFFIDVARECF 305
++DN LE + + FN +S V + R ++ F+ VA +
Sbjct: 186 CTVDNP----------VLERFISLFNSVSQWVQLMILSKPTAPQRALVITHFVHVAEKLL 235
Query: 306 NIGNFNSMMAIISGMNLSPVARLKKTWSKV--KTAK-FDVLEHHMDPSSNFCNYRTALQG 362
+ NFN++MA++ G++ S ++RLK+T S V +T K ++ L + + N+ NYR L
Sbjct: 236 QLQNFNTLMAVVGGLSHSSISRLKETHSHVSPETIKLWEGLTELVTATGNYGNYRRRLAA 295
Query: 363 ATQRSQMANSSREKIVIPVFNLFVKDIYFLHKIHTNHL--PNGHINFKKFWEISRQIHEF 420
P+ + +KD+ L + L +N K ++ + E
Sbjct: 296 CV-----------GFRFPILGVHLKDLVALQLALPDWLDPARTRLNGAKMKQLFSILEEL 344
Query: 421 MTWTQVECPFEKDKKIQSYLLTA--PIYSEEALFVASFESE 459
T + P + + + S L + +E+ L+ S + E
Sbjct: 345 AMVTSLRPPVQANPDLLSLLTVSLDQYQTEDELYQLSLQRE 385
>gi|149158729 RAS guanyl releasing protein 2 [Homo sapiens]
Length = 609
Score = 70.1 bits (170), Expect = 4e-12
Identities = 86/401 (21%), Positives = 160/401 (39%), Gaps = 54/401 (13%)
Query: 66 DRTYIFTFLLSSRVFMPPHDLLARVGQICVEQKQQLEAGPEKAKLKSFSAKIVQLLKEWT 125
D + FL+ ++P L A++ I + + K S K L++ W
Sbjct: 32 DPQLVRMFLMMHPWYIPSSQLAAKLLHIYQQSR--------KDNSNSLQVKTCHLVRYWI 83
Query: 126 EAFPYDFQDEKAMAELKAITHRVTQCDEENGTVKKAIAQMTQSLLLSLAARSQLQELREK 185
AFP +F +AE I D+E S L+ + + + R+
Sbjct: 84 SAFPAEFDLNPELAE--QIKELKALLDQEGNR--------RHSSLIDIDSVPTYKWKRQ- 132
Query: 186 LRPPAVDKGPILKTKPPAAQKDILGVCCDPLVLAQQLTHIELDRVSSIYPEDLMQIVSHM 245
+ P+ + K + +L +P+ LA+ LT++E I +D V+H
Sbjct: 133 ----VTQRNPVGQKK---RKMSLLFDHLEPMELAEHLTYLEYRSFCKILFQDYHSFVTHG 185
Query: 246 DSLDNHRCRGDLTKTYSLEAYDNWFNCLSMLVATEVCRVVKKKHRTRMLEFFIDVARECF 305
++DN LE + + FN +S V + R ++ F+ VA +
Sbjct: 186 CTVDNP----------VLERFISLFNSVSQWVQLMILSKPTAPQRALVITHFVHVAEKLL 235
Query: 306 NIGNFNSMMAIISGMNLSPVARLKKTWSKV--KTAK-FDVLEHHMDPSSNFCNYRTALQG 362
+ NFN++MA++ G++ S ++RLK+T S V +T K ++ L + + N+ NYR L
Sbjct: 236 QLQNFNTLMAVVGGLSHSSISRLKETHSHVSPETIKLWEGLTELVTATGNYGNYRRRLAA 295
Query: 363 ATQRSQMANSSREKIVIPVFNLFVKDIYFLHKIHTNHL--PNGHINFKKFWEISRQIHEF 420
P+ + +KD+ L + L +N K ++ + E
Sbjct: 296 CV-----------GFRFPILGVHLKDLVALQLALPDWLDPARTRLNGAKMKQLFSILEEL 344
Query: 421 MTWTQVECPFEKDKKIQSYLLTA--PIYSEEALFVASFESE 459
T + P + + + S L + +E+ L+ S + E
Sbjct: 345 AMVTSLRPPVQANPDLLSLLTVSLDQYQTEDELYQLSLQRE 385
>gi|149158727 RAS guanyl releasing protein 2 [Homo sapiens]
Length = 609
Score = 70.1 bits (170), Expect = 4e-12
Identities = 86/401 (21%), Positives = 160/401 (39%), Gaps = 54/401 (13%)
Query: 66 DRTYIFTFLLSSRVFMPPHDLLARVGQICVEQKQQLEAGPEKAKLKSFSAKIVQLLKEWT 125
D + FL+ ++P L A++ I + + K S K L++ W
Sbjct: 32 DPQLVRMFLMMHPWYIPSSQLAAKLLHIYQQSR--------KDNSNSLQVKTCHLVRYWI 83
Query: 126 EAFPYDFQDEKAMAELKAITHRVTQCDEENGTVKKAIAQMTQSLLLSLAARSQLQELREK 185
AFP +F +AE I D+E S L+ + + + R+
Sbjct: 84 SAFPAEFDLNPELAE--QIKELKALLDQEGNR--------RHSSLIDIDSVPTYKWKRQ- 132
Query: 186 LRPPAVDKGPILKTKPPAAQKDILGVCCDPLVLAQQLTHIELDRVSSIYPEDLMQIVSHM 245
+ P+ + K + +L +P+ LA+ LT++E I +D V+H
Sbjct: 133 ----VTQRNPVGQKK---RKMSLLFDHLEPMELAEHLTYLEYRSFCKILFQDYHSFVTHG 185
Query: 246 DSLDNHRCRGDLTKTYSLEAYDNWFNCLSMLVATEVCRVVKKKHRTRMLEFFIDVARECF 305
++DN LE + + FN +S V + R ++ F+ VA +
Sbjct: 186 CTVDNP----------VLERFISLFNSVSQWVQLMILSKPTAPQRALVITHFVHVAEKLL 235
Query: 306 NIGNFNSMMAIISGMNLSPVARLKKTWSKV--KTAK-FDVLEHHMDPSSNFCNYRTALQG 362
+ NFN++MA++ G++ S ++RLK+T S V +T K ++ L + + N+ NYR L
Sbjct: 236 QLQNFNTLMAVVGGLSHSSISRLKETHSHVSPETIKLWEGLTELVTATGNYGNYRRRLAA 295
Query: 363 ATQRSQMANSSREKIVIPVFNLFVKDIYFLHKIHTNHL--PNGHINFKKFWEISRQIHEF 420
P+ + +KD+ L + L +N K ++ + E
Sbjct: 296 CV-----------GFRFPILGVHLKDLVALQLALPDWLDPARTRLNGAKMKQLFSILEEL 344
Query: 421 MTWTQVECPFEKDKKIQSYLLTA--PIYSEEALFVASFESE 459
T + P + + + S L + +E+ L+ S + E
Sbjct: 345 AMVTSLRPPVQANPDLLSLLTVSLDQYQTEDELYQLSLQRE 385
>gi|26051258 RAS guanyl releasing protein 4 isoform a [Homo sapiens]
Length = 673
Score = 69.3 bits (168), Expect = 7e-12
Identities = 74/325 (22%), Positives = 132/325 (40%), Gaps = 38/325 (11%)
Query: 144 ITHRVTQCDEENGTVKKAIAQMTQSLLLSLAARSQLQELREKLRPPAVDKGPILKTKPPA 203
+ H+ Q +E G +A+ S L S L P P+ + P
Sbjct: 135 VMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLS-------PGGPGPPLPMSSPGL 187
Query: 204 AQKDILGVCCDPLV---LAQQLTHIELDRVSSIYPEDLMQIVSHMDSLDNHRCRGDLTKT 260
+K + + D L LAQ LT++E +I P+DL V +G +
Sbjct: 188 GKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYV----------LQGSVRGC 237
Query: 261 YSLEAYDNWFNCLSMLVATEVCRVVKKKHRTRMLEFFIDVARECFNIGNFNSMMAIISGM 320
+LE N +S V V R ++L+ FI VA+ + NFN++MA+ G+
Sbjct: 238 PALEGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGL 297
Query: 321 NLSPVARLKKTWSKV---KTAKFDVLEHHMDPSSNFCNYRTALQGATQRSQMANSSREKI 377
S ++RLK + + + T L + +N+ YR G
Sbjct: 298 CHSAISRLKDSHAHLSPDSTKALLELTELLASHNNYARYRRTWAGCA-----------GF 346
Query: 378 VIPVFNLFVKDIYFLHKIHTNHLPNGHINFKKFWEISRQIHEFMTWTQVECPFEKDKKIQ 437
+PV + +KD+ LH+ + LP+G ++ K + ++ E + P ++ +
Sbjct: 347 RLPVLGVHLKDLVSLHEAQPDRLPDGRLHLPKLNNLYLRLQELVALQGQHPPCSANEDL- 405
Query: 438 SYLLTAPI---YSEEALFVASFESE 459
+LLT + Y+E+ ++ S+ E
Sbjct: 406 LHLLTLSLDLFYTEDEIYELSYARE 430
>gi|119392077 Rap guanine nucleotide exchange factor (GEF) 5 [Homo
sapiens]
Length = 730
Score = 69.3 bits (168), Expect = 7e-12
Identities = 68/249 (27%), Positives = 113/249 (45%), Gaps = 27/249 (10%)
Query: 218 LAQQLTHIELDRVSSIYPEDLMQIVSHMDSLDNHRCRGDLTKTYSLEAYDNWFNCLSMLV 277
LA +L + + +SI+ ++L+ H T +L N + + V
Sbjct: 499 LALELMNFDWSLFNSIHEQELIYFTFSRQGSGEH--------TANLSLLLQRCNEVQLWV 550
Query: 278 ATEVCRVVKKKHRTRMLEFFIDVARECFNIGNFNSMMAIISGMNLSPVARLKKTWSKV-- 335
ATE+ + R ++++ FI +A C N NS AI+ G+N + V+RL +TW K+
Sbjct: 551 ATEILLCSQLGKRVQLVKKFIKIAAHCKAQRNLNSFFAIVMGLNTASVSRLSQTWEKIPG 610
Query: 336 KTAK-FDVLEHHMDPSSNFCNYRTALQGATQRSQMANSSREKIVIPVFNLFVKDIYFLHK 394
K K F LE DPS N YR A + + IP L +KD+ F+H+
Sbjct: 611 KFKKLFSELESLTDPSLNHKAYRDAFK-----------KMKPPKIPFMPLLLKDVTFIHE 659
Query: 395 IHTNHLPNGHINFKKFWEIS---RQIHEFMTWTQVECPFEKDKKIQSYL-LTAPIYSEEA 450
+ L N +NF+K I+ R + T + ++ ++++SY+ I S++A
Sbjct: 660 GNKTFLDN-LVNFEKLHMIADTVRTLRHCRTNQFGDLSPKEHQELKSYVNHLYVIDSQQA 718
Query: 451 LFVASFESE 459
LF S E
Sbjct: 719 LFELSHRIE 727
>gi|239582765 ral guanine nucleotide dissociation stimulator-like 3
isoform 1 [Homo sapiens]
Length = 716
Score = 68.2 bits (165), Expect = 2e-11
Identities = 102/416 (24%), Positives = 175/416 (42%), Gaps = 61/416 (14%)
Query: 45 LISGSLEALMEHLVPTVDYYPDRTYIFTFLLSSRVFMPPHDLLARVGQICVEQKQQLEAG 104
L + LE L+ LV D D +++ FL + R F+P LL G + G
Sbjct: 69 LRAARLERLVGELV-FGDREQDPSFMPAFLATYRTFVPTACLL---GFLLPPMPPPPPPG 124
Query: 105 PEKAKLK----SFSAK---IVQLLKEWTEAFPYDFQDEKAMAELKAITHRVTQCDEENGT 157
E K SF+ +V +L W + P DF+D A ++L ++ + +
Sbjct: 125 VEIKKTAVQDLSFNKNLRAVVSVLGSWLQDHPQDFRDPPAHSDLGSVRTFLGWAAPGSAE 184
Query: 158 VKKAIAQMTQSLLLSLAARSQLQELREKLRPPAVDKGP--ILKTKPPAAQK--------- 206
+KA + L A R Q +E PP V GP + +T P + +
Sbjct: 185 AQKAEKLLED--FLEEAEREQEEE------PPQVWTGPPRVAQTSDPDSSEACAEEEEGL 236
Query: 207 -----DILGVCCDPLVLAQQLTHIELDRVSSIYPEDLMQIVSHMDSLDNHRCR-GDLTKT 260
+L D + A+QLT I+L+ S + ++ + S+ + R R G +
Sbjct: 237 MPQGPQLLDFSVDEV--AEQLTLIDLELFSKV------RLYECLGSVWSQRDRPGAAGAS 288
Query: 261 YSLEAYDNWFNCLSMLVATEVCRV--VKKKHRTRMLEFFIDVARECFNIGNFNSMMAIIS 318
++ A FN ++ V V + R + LE +I +A+ C + NF+S+ AI+S
Sbjct: 289 PTVRATVAQFNTVTGCVLGSVLGAPGLAAPQRAQRLEKWIRIAQRCRELRNFSSLRAILS 348
Query: 319 GMNLSPVARLKKTW---SKVKTAKFDVLEHHMDPSSNFCNYRTAL--QGATQRSQMANSS 373
+ +P+ RLK++W S+ + F L +N + R L + AT+ SQ +++
Sbjct: 349 ALQSNPIYRLKRSWGAVSREPLSTFRKLSQIFSDENNHLSSREILFQEEATEGSQEEDNT 408
Query: 374 REKI-------VIPVFNLFVKDIYFLHKIHTNHLPNGHINF---KKFWEISRQIHE 419
+ +P F+ D+ L + L INF +K WEI +I +
Sbjct: 409 PGSLPSKPPPGPVPYLGTFLTDLVMLDTALPDMLEGDLINFEKRRKEWEILARIQQ 464
>gi|239582763 ral guanine nucleotide dissociation stimulator-like 3
isoform 2 [Homo sapiens]
Length = 710
Score = 68.2 bits (165), Expect = 2e-11
Identities = 102/416 (24%), Positives = 175/416 (42%), Gaps = 61/416 (14%)
Query: 45 LISGSLEALMEHLVPTVDYYPDRTYIFTFLLSSRVFMPPHDLLARVGQICVEQKQQLEAG 104
L + LE L+ LV D D +++ FL + R F+P LL G + G
Sbjct: 69 LRAARLERLVGELV-FGDREQDPSFMPAFLATYRTFVPTACLL---GFLLPPMPPPPPPG 124
Query: 105 PEKAKLK----SFSAK---IVQLLKEWTEAFPYDFQDEKAMAELKAITHRVTQCDEENGT 157
E K SF+ +V +L W + P DF+D A ++L ++ + +
Sbjct: 125 VEIKKTAVQDLSFNKNLRAVVSVLGSWLQDHPQDFRDPPAHSDLGSVRTFLGWAAPGSAE 184
Query: 158 VKKAIAQMTQSLLLSLAARSQLQELREKLRPPAVDKGP--ILKTKPPAAQK--------- 206
+KA + L A R Q +E PP V GP + +T P + +
Sbjct: 185 AQKAEKLLED--FLEEAEREQEEE------PPQVWTGPPRVAQTSDPDSSEACAEEEEGL 236
Query: 207 -----DILGVCCDPLVLAQQLTHIELDRVSSIYPEDLMQIVSHMDSLDNHRCR-GDLTKT 260
+L D + A+QLT I+L+ S + ++ + S+ + R R G +
Sbjct: 237 MPQGPQLLDFSVDEV--AEQLTLIDLELFSKV------RLYECLGSVWSQRDRPGAAGAS 288
Query: 261 YSLEAYDNWFNCLSMLVATEVCRV--VKKKHRTRMLEFFIDVARECFNIGNFNSMMAIIS 318
++ A FN ++ V V + R + LE +I +A+ C + NF+S+ AI+S
Sbjct: 289 PTVRATVAQFNTVTGCVLGSVLGAPGLAAPQRAQRLEKWIRIAQRCRELRNFSSLRAILS 348
Query: 319 GMNLSPVARLKKTW---SKVKTAKFDVLEHHMDPSSNFCNYRTAL--QGATQRSQMANSS 373
+ +P+ RLK++W S+ + F L +N + R L + AT+ SQ +++
Sbjct: 349 ALQSNPIYRLKRSWGAVSREPLSTFRKLSQIFSDENNHLSSREILFQEEATEGSQEEDNT 408
Query: 374 REKI-------VIPVFNLFVKDIYFLHKIHTNHLPNGHINF---KKFWEISRQIHE 419
+ +P F+ D+ L + L INF +K WEI +I +
Sbjct: 409 PGSLPSKPPPGPVPYLGTFLTDLVMLDTALPDMLEGDLINFEKRRKEWEILARIQQ 464
>gi|226246575 RAS guanyl releasing protein 4 isoform b [Homo
sapiens]
Length = 659
Score = 67.4 bits (163), Expect = 3e-11
Identities = 59/248 (23%), Positives = 107/248 (43%), Gaps = 28/248 (11%)
Query: 218 LAQQLTHIELDRVSSIYPEDLMQIVSHMDSLDNHRCRGDLTKTYSLEAYDNWFNCLSMLV 277
LAQ LT++E +I P+DL V +G + +LE N +S V
Sbjct: 191 LAQHLTYLEFRSFQAITPQDLRSYV----------LQGSVRGCPALEGSVGLSNSVSRWV 240
Query: 278 ATEVCRVVKKKHRTRMLEFFIDVARECFNIGNFNSMMAIISGMNLSPVARLKKTWSKV-- 335
V R ++L+ FI VA+ + NFN++MA+ G+ S ++RLK + + +
Sbjct: 241 QVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHSAISRLKDSHAHLSP 300
Query: 336 -KTAKFDVLEHHMDPSSNFCNYRTALQGATQRSQMANSSREKIVIPVFNLFVKDIYFLHK 394
T L + +N+ YR G +PV + +KD+ LH+
Sbjct: 301 DSTKALLELTELLASHNNYARYRRTWAGCA-----------GFRLPVLGVHLKDLVSLHE 349
Query: 395 IHTNHLPNGHINFKKFWEISRQIHEFMTWTQVECPFEKDKKIQSYLLTAPI---YSEEAL 451
+ LP+G ++ K + ++ E + P ++ + +LLT + Y+E+ +
Sbjct: 350 AQPDRLPDGRLHLPKLNNLYLRLQELVALQGQHPPCSANEDL-LHLLTLSLDLFYTEDEI 408
Query: 452 FVASFESE 459
+ S+ E
Sbjct: 409 YELSYARE 416
>gi|38373677 guanine nucleotide-releasing factor 2 isoform b [Homo
sapiens]
Length = 1095
Score = 65.9 bits (159), Expect = 8e-11
Identities = 100/445 (22%), Positives = 176/445 (39%), Gaps = 82/445 (18%)
Query: 25 GERGGGAGGGSGDLIFQDGHLISGSLEALMEHLVPTVDYYPDRTYIFTFLLSSRVFMPPH 84
G+ G GGSGD+ L+ + E + LV Y FL + R F+ P
Sbjct: 704 GDDGPDVRGGSGDI------LLVHATETDRKDLV---------LYCEAFLTTYRTFISPE 748
Query: 85 DLLARVGQICVEQKQQLEAGPEKAKLKSFSAKIVQLLKEWTEAFPYDFQDEKAMAELKAI 144
+L+ ++ Q E+ +K K+ +V+++ DE + EL
Sbjct: 749 ELIKKL-QYRYEKFSPFADTFKKRVSKNTFFVLVRVV------------DELCLVELT-- 793
Query: 145 THRVTQCDEENGTVKKAIAQMTQSLLLSLAARSQLQELR--EKLRPPAVDKGPILKTKPP 202
+ I ++ L+ L +L R K VD+ +L+
Sbjct: 794 ---------------EEILKLLMELVFRLVCNGELSLARVLRKNILDKVDQKKLLRCATS 838
Query: 203 AAQKDILGVCCDPLVL--------AQQLTHIELDRVSSI-YPEDLMQIVSHMDSLDNHRC 253
+ GV P L A+QLT ++ + I PE L+ +
Sbjct: 839 SQPLAARGVAARPGTLHDFHSHEIAEQLTLLDAELFYKIEIPEVLLWAKEQNEE------ 892
Query: 254 RGDLTKTYSLEAYDNWFNCLSMLVATEVCRVVKKKHRTRMLEFFIDVARECFNIGNFNSM 313
K+ +L + FN +S V + + K + R R+L FI + + + NFNS
Sbjct: 893 -----KSPNLTQFTEHFNNMSYWVRSIIMLQEKAQDRERLLLKFIKIMKHLRKLNNFNSY 947
Query: 314 MAIISGMNLSPVARLKKTWSKVKTAKFDVLEHHMDPSSNFCNYRTALQGATQRSQMANSS 373
+AI+S ++ +P+ RL+ W K + +D SS+F YR AL S
Sbjct: 948 LAILSALDSAPIRRLE--WQKQTSEGLAEYCTLIDSSSSFRAYRAAL-----------SE 994
Query: 374 REKIVIPVFNLFVKDIYFLHKIHTNHLPNGHINFKKFWEISRQIHEFMTWTQVECPFEKD 433
E IP L ++D+ F+H + +++ +G +NF K W+ + + Q ++
Sbjct: 995 VEPPCIPYLGLILQDLTFVHLGNPDYI-DGKVNFSKRWQQFNILDSMRCFQQAHYDMRRN 1053
Query: 434 KKIQSYLLT-APIYSEEALFVASFE 457
I ++ + +EEAL+ S +
Sbjct: 1054 DDIINFFNDFSDHLAEEALWELSLK 1078
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,477,667
Number of Sequences: 37866
Number of extensions: 800239
Number of successful extensions: 4134
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 55
Number of HSP's successfully gapped in prelim test: 15
Number of HSP's that attempted gapping in prelim test: 3971
Number of HSP's gapped (non-prelim): 123
length of query: 481
length of database: 18,247,518
effective HSP length: 106
effective length of query: 375
effective length of database: 14,233,722
effective search space: 5337645750
effective search space used: 5337645750
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.