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Search of human proteins with 116812588
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|116812588 polycystic kidney disease 2-like 2 [Homo sapiens]
(613 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|116812588 polycystic kidney disease 2-like 2 [Homo sapiens] 1249 0.0
gi|4505835 polycystin 2 [Homo sapiens] 572 e-163
gi|33598944 polycystic kidney disease 2-like 1 [Homo sapiens] 566 e-161
gi|116006951 polycystin 1-like 2 isoform a [Homo sapiens] 204 1e-52
gi|5174633 receptor for egg jelly-like protein precursor [Homo s... 110 3e-24
gi|205360962 polycystin 1 isoform 2 precursor [Homo sapiens] 84 3e-16
gi|205360954 polycystin 1 isoform 1 precursor [Homo sapiens] 84 3e-16
gi|19923084 polycystin-1L1 [Homo sapiens] 78 2e-14
gi|239756622 PREDICTED: polycystic kidney disease 1-like 3 [Homo... 67 5e-11
gi|239751108 PREDICTED: polycystic kidney disease 1-like 3 [Homo... 67 5e-11
gi|239745596 PREDICTED: polycystin 1-like 3 [Homo sapiens] 67 5e-11
gi|31559825 polycystin 1-like 3 [Homo sapiens] 67 5e-11
gi|53832011 calcium channel, voltage-dependent, T type, alpha 1H... 66 1e-10
gi|53832009 calcium channel, voltage-dependent, T type, alpha 1H... 66 1e-10
gi|192807298 calcium channel, voltage-dependent, L type, alpha 1... 63 9e-10
gi|20070163 voltage-dependent calcium channel alpha 1G subunit i... 62 2e-09
gi|187828892 calcium channel, alpha 1A subunit isoform 4 [Homo s... 62 2e-09
gi|187828880 calcium channel, alpha 1A subunit isoform 3 [Homo s... 62 2e-09
gi|38505292 voltage-dependent calcium channel alpha 1G subunit i... 62 2e-09
gi|38505290 voltage-dependent calcium channel alpha 1G subunit i... 62 2e-09
gi|38505288 voltage-dependent calcium channel alpha 1G subunit i... 62 2e-09
gi|38505286 voltage-dependent calcium channel alpha 1G subunit i... 62 2e-09
gi|38505284 voltage-dependent calcium channel alpha 1G subunit i... 62 2e-09
gi|38505282 voltage-dependent calcium channel alpha 1G subunit i... 62 2e-09
gi|38505280 voltage-dependent calcium channel alpha 1G subunit i... 62 2e-09
gi|38505278 voltage-dependent calcium channel alpha 1G subunit i... 62 2e-09
gi|38505276 voltage-dependent calcium channel alpha 1G subunit i... 62 2e-09
gi|38505274 voltage-dependent calcium channel alpha 1G subunit i... 62 2e-09
gi|38505272 voltage-dependent calcium channel alpha 1G subunit i... 62 2e-09
gi|38505270 voltage-dependent calcium channel alpha 1G subunit i... 62 2e-09
>gi|116812588 polycystic kidney disease 2-like 2 [Homo sapiens]
Length = 613
Score = 1249 bits (3233), Expect = 0.0
Identities = 613/613 (100%), Positives = 613/613 (100%)
Query: 1 MAEASRWHRGGASKHKLHYRKEVEITTTLQELLLYFIFLINLCILTFGMVNPHMYYLNKV 60
MAEASRWHRGGASKHKLHYRKEVEITTTLQELLLYFIFLINLCILTFGMVNPHMYYLNKV
Sbjct: 1 MAEASRWHRGGASKHKLHYRKEVEITTTLQELLLYFIFLINLCILTFGMVNPHMYYLNKV 60
Query: 61 MSSLFLDTSVPGEERTNFKSIRSITDFWKFMEGPLLEGLYWDSWYNNQQLYNLKNSSRIY 120
MSSLFLDTSVPGEERTNFKSIRSITDFWKFMEGPLLEGLYWDSWYNNQQLYNLKNSSRIY
Sbjct: 61 MSSLFLDTSVPGEERTNFKSIRSITDFWKFMEGPLLEGLYWDSWYNNQQLYNLKNSSRIY 120
Query: 121 YENILLGVPRVRQLKVRNNTCKVYSSFQSLMSECYGKYTSANEDLSNFGLQINTEWRYST 180
YENILLGVPRVRQLKVRNNTCKVYSSFQSLMSECYGKYTSANEDLSNFGLQINTEWRYST
Sbjct: 121 YENILLGVPRVRQLKVRNNTCKVYSSFQSLMSECYGKYTSANEDLSNFGLQINTEWRYST 180
Query: 181 SNTNSPWHWGFLGVYRNGGYIFTLSKSKSETKNKFIDLRLNSWITRGTRVIFIDFSLYNA 240
SNTNSPWHWGFLGVYRNGGYIFTLSKSKSETKNKFIDLRLNSWITRGTRVIFIDFSLYNA
Sbjct: 181 SNTNSPWHWGFLGVYRNGGYIFTLSKSKSETKNKFIDLRLNSWITRGTRVIFIDFSLYNA 240
Query: 241 NVNLFCIIRLVAEFPATGGILTSWQFYSVKLLRYVSYYDYFIASCEITFCIFLFVFTTQE 300
NVNLFCIIRLVAEFPATGGILTSWQFYSVKLLRYVSYYDYFIASCEITFCIFLFVFTTQE
Sbjct: 241 NVNLFCIIRLVAEFPATGGILTSWQFYSVKLLRYVSYYDYFIASCEITFCIFLFVFTTQE 300
Query: 301 VKKIKEFKSAYFKSIWNWLELLLLLLCFVAVSFNTYYNVQIFLLLGQLLKSTEKYSDFYF 360
VKKIKEFKSAYFKSIWNWLELLLLLLCFVAVSFNTYYNVQIFLLLGQLLKSTEKYSDFYF
Sbjct: 301 VKKIKEFKSAYFKSIWNWLELLLLLLCFVAVSFNTYYNVQIFLLLGQLLKSTEKYSDFYF 360
Query: 361 LACWHIYYNNIIAITIFFAWIKIFKFISFNKTMSQLSSTLSRCVKDIVGFAIMFFIIFFA 420
LACWHIYYNNIIAITIFFAWIKIFKFISFNKTMSQLSSTLSRCVKDIVGFAIMFFIIFFA
Sbjct: 361 LACWHIYYNNIIAITIFFAWIKIFKFISFNKTMSQLSSTLSRCVKDIVGFAIMFFIIFFA 420
Query: 421 YAQLGFLVFGSQVDDFSTFQNSIFAQFRIVLGDFNFAGIQQANPILGPIYFITFIFFVFF 480
YAQLGFLVFGSQVDDFSTFQNSIFAQFRIVLGDFNFAGIQQANPILGPIYFITFIFFVFF
Sbjct: 421 YAQLGFLVFGSQVDDFSTFQNSIFAQFRIVLGDFNFAGIQQANPILGPIYFITFIFFVFF 480
Query: 481 VLLNMFLAIINDTYSEVKADYSIGRRLDFELGKMIKQSYKNVLEKFRLKKAQKDEDKKTK 540
VLLNMFLAIINDTYSEVKADYSIGRRLDFELGKMIKQSYKNVLEKFRLKKAQKDEDKKTK
Sbjct: 481 VLLNMFLAIINDTYSEVKADYSIGRRLDFELGKMIKQSYKNVLEKFRLKKAQKDEDKKTK 540
Query: 541 GSGDLAEQARREGFDENEIQNAEQMKKWKERLEKKYYSMEIQDDYQPVTQEEFRDGTTTK 600
GSGDLAEQARREGFDENEIQNAEQMKKWKERLEKKYYSMEIQDDYQPVTQEEFRDGTTTK
Sbjct: 541 GSGDLAEQARREGFDENEIQNAEQMKKWKERLEKKYYSMEIQDDYQPVTQEEFRDGTTTK 600
Query: 601 YKMRFSECLTKRI 613
YKMRFSECLTKRI
Sbjct: 601 YKMRFSECLTKRI 613
>gi|4505835 polycystin 2 [Homo sapiens]
Length = 968
Score = 572 bits (1473), Expect = e-163
Identities = 275/548 (50%), Positives = 384/548 (70%), Gaps = 12/548 (2%)
Query: 21 KEVEITTTLQELLLYFIFLINLCILTFGMVNPHMYYLNKVMSSLFLDTSVPGEERTNFKS 80
+E + + L+EL+ Y +FLI LCILT+GM++ ++YY ++MS LFLDT V E+TNFK+
Sbjct: 213 REKYLKSVLRELVTYLLFLIVLCILTYGMMSSNVYYYTRMMSQLFLDTPVSKTEKTNFKT 272
Query: 81 IRSITDFWKFMEGPLLEGLYWDSWYNNQQLYNLKNSSRIYYENILLGVPRVRQLKVRNNT 140
+ S+ DFWKF EG LL+GLYW +NQ N S I+YEN+LLGVPR+RQL+VRN +
Sbjct: 273 LSSMEDFWKFTEGSLLDGLYWKMQPSNQT--EADNRSFIFYENLLLGVPRIRQLRVRNGS 330
Query: 141 CKVYSSFQSLMSECYGKYTSANEDLSNFGLQINTEWRY-STSNTNSPWHWGFLGVYRNGG 199
C + + + ECY Y+ ++ED + FG + T W Y S + N HWG + Y G
Sbjct: 331 CSIPQDLRDEIKECYDVYSVSSEDRAPFGPRNGTAWIYTSEKDLNGSSHWGIIATYSGAG 390
Query: 200 YIFTLSKSKSETKNKFIDLRLNSWITRGTRVIFIDFSLYNANVNLFCIIRLVAEFPATGG 259
Y LS+++ ET + L+ N W+ RGTR FIDFS+YNAN+NLFC++RL+ EFPATGG
Sbjct: 391 YYLDLSRTREETAAQVASLKKNVWLDRGTRATFIDFSVYNANINLFCVVRLLVEFPATGG 450
Query: 260 ILTSWQFYSVKLLRYVSYYDYFIASCEITFCIFLFVFTTQEVKKIKEFKSAYFKSIWNWL 319
++ SWQF +KL+RYV+ +D+F+A+CEI FC F+F + +E+ +I+ K YF+S WN L
Sbjct: 451 VIPSWQFQPLKLIRYVTTFDFFLAACEIIFCFFIFYYVVEEILEIRIHKLHYFRSFWNCL 510
Query: 320 ELLLLLLCFVAVSFNTYYNVQIFLLLGQLLKSTEKYSDFYFLACWHIYYNNIIAITIFFA 379
++++++L VA+ N Y + +LL Q L+ + +F LA W I +NNI A+T+FF
Sbjct: 511 DVVIVVLSVVAIGINIYRTSNVEVLL-QFLEDQNTFPNFEHLAYWQIQFNNIAAVTVFFV 569
Query: 380 WIKIFKFISFNKTMSQLSSTLSRCVKDIVGFAIMFFIIFFAYAQLGFLVFGSQVDDFSTF 439
WIK+FKFI+FN+TMSQLS+T+SRC KD+ GFAIMFFIIF AYAQL +LVFG+QVDDFSTF
Sbjct: 570 WIKLFKFINFNRTMSQLSTTMSRCAKDLFGFAIMFFIIFLAYAQLAYLVFGTQVDDFSTF 629
Query: 440 QNSIFAQFRIVLGDFNFAGIQQANPILGPIYFITFIFFVFFVLLNMFLAIINDTYSEVKA 499
Q IF QFRI+LGD NFA I++AN +LGPIYF TF+FF+FF+LLNMFLAIINDTYSEVK+
Sbjct: 630 QECIFTQFRIILGDINFAEIEEANRVLGPIYFTTFVFFMFFILLNMFLAIINDTYSEVKS 689
Query: 500 DYSIGRRLDFELGKMIKQSYKNVLEKFRLKKAQKDEDKKTKGSG-------DLAEQARRE 552
D + ++ + EL +I++ Y L K +LKK D+ ++ G +L + + +
Sbjct: 690 DLA-QQKAEMELSDLIRKGYHKALVKLKLKKNTVDDISESLRQGGGKLNFDELRQDLKGK 748
Query: 553 GFDENEIQ 560
G + EI+
Sbjct: 749 GHTDAEIE 756
>gi|33598944 polycystic kidney disease 2-like 1 [Homo sapiens]
Length = 805
Score = 566 bits (1458), Expect = e-161
Identities = 277/547 (50%), Positives = 379/547 (69%), Gaps = 12/547 (2%)
Query: 21 KEVEITTTLQELLLYFIFLINLCILTFGMVNPHMYYLNKVMSSLFLDTSVPGEERTNFKS 80
+E+ I TTL+ELL+Y +FL+++C+LT+GM + YY KVMS LFL T P + +F++
Sbjct: 93 RELYIKTTLRELLVYIVFLVDICLLTYGMTSSSAYYYTKVMSELFLHT--PSDTGVSFQA 150
Query: 81 IRSITDFWKFMEGPLLEGLYWDSWYNNQQLYNLKNSSRIYYENILLGVPRVRQLKVRNNT 140
I S+ DFW F +GPLL+ LYW WYNNQ L + +S IYYEN+LLGVPR+RQLKVRN++
Sbjct: 151 ISSMADFWDFAQGPLLDSLYWTKWYNNQSLGHGSHSF-IYYENMLLGVPRLRQLKVRNDS 209
Query: 141 CKVYSSFQSLMSECYGKYTSANEDLSNFGLQINTEWRYSTSNTNSPW-HWGFLGVYRNGG 199
C V+ F+ + CY Y+ E+ FG T W Y + + + HWG L Y GG
Sbjct: 210 CVVHEDFREDILSCYDVYSPDKEEQLPFGPFNGTAWTYHSQDELGGFSHWGRLTSYSGGG 269
Query: 200 YIFTLSKSKSETKNKFIDLRLNSWITRGTRVIFIDFSLYNANVNLFCIIRLVAEFPATGG 259
Y L S+ + L+ W+ RGTRV+FIDFS+YNAN+NLFC++RLV EFPATGG
Sbjct: 270 YYLDLPGSRQGSAEALRALQEGLWLDRGTRVVFIDFSVYNANINLFCVLRLVVEFPATGG 329
Query: 260 ILTSWQFYSVKLLRYVSYYDYFIASCEITFCIFLFVFTTQEVKKIKEFKSAYFKSIWNWL 319
+ SWQ +VKL+RYVS +D+FI CE+ FC+F+F + +E+ ++ + Y SIWN L
Sbjct: 330 AIPSWQIRTVKLIRYVSNWDFFIVGCEVIFCVFIFYYVVEEILELHIHRLRYLSSIWNIL 389
Query: 320 ELLLLLLCFVAVSFNTYYNVQIFLLLGQLLKSTEKYSDFYFLACWHIYYNNIIAITIFFA 379
+L+++LL VAV F+ + +++ L+G+LL+ Y+DF FLA W YNN+ A+ +FFA
Sbjct: 390 DLVVILLSIVAVGFHIFRTLEVNRLMGKLLQQPNTYADFEFLAFWQTQYNNMNAVNLFFA 449
Query: 380 WIKIFKFISFNKTMSQLSSTLSRCVKDIVGFAIMFFIIFFAYAQLGFLVFGSQVDDFSTF 439
WIKIFK+ISFNKTM+QLSSTL+RC KDI+GFA+MFFI+FFAYAQLG+L+FG+QV++FSTF
Sbjct: 450 WIKIFKYISFNKTMTQLSSTLARCAKDILGFAVMFFIVFFAYAQLGYLLFGTQVENFSTF 509
Query: 440 QNSIFAQFRIVLGDFNFAGIQQANPILGPIYFITFIFFVFFVLLNMFLAIINDTYSEVKA 499
IF QFRI+LGDF++ I AN ILGP YF+T++FFVFFVLLNMFLAIINDTYSEVK
Sbjct: 510 IKCIFTQFRIILGDFDYNAIDNANRILGPAYFVTYVFFVFFVLLNMFLAIINDTYSEVKE 569
Query: 500 DYSIGRRLDFELGKMIKQSYKNVLEKFRLKKAQKDEDKKTKGSG-------DLAEQARRE 552
+ + G++ + +L ++KQ Y L + RL+K + + +K G D R
Sbjct: 570 ELA-GQKDELQLSDLLKQGYNKTLLRLRLRKERVSDVQKVLQGGEQEIQFEDFTNTLREL 628
Query: 553 GFDENEI 559
G E+EI
Sbjct: 629 GHAEHEI 635
>gi|116006951 polycystin 1-like 2 isoform a [Homo sapiens]
Length = 2459
Score = 204 bits (520), Expect = 1e-52
Identities = 136/539 (25%), Positives = 255/539 (47%), Gaps = 30/539 (5%)
Query: 14 KHKLHYRKEVEITTTLQELLLYFIFLINLCILTFGMVNPHMYYLNKVMSSLFLDTSVPGE 73
K K + KE + ++E+L Y FL L ++ +G +P Y+LN+ + F
Sbjct: 1933 KMKTTHLKEQKAFALIREILAYLGFLWMLLLVAYGQRDPSAYHLNRHLQHSFT------- 1985
Query: 74 ERTNFKSIRSITDFWKFMEGPLLEGLYWDSWYNNQQLYNLKNSSRIYYENILLGVPRVRQ 133
F + +F+K+ L+ LY + + +S+ L+G ++RQ
Sbjct: 1986 --RGFSGVLGFREFFKWANTTLVSNLY-----GHPPGFITDGNSK------LVGSAQIRQ 2032
Query: 134 LKVRNNTCKVYSSFQSLMSECYGKYTSANEDLSNFGLQIN----TEWRYSTSNTNSPWH- 188
++V+ ++C + Q+ ++ C Y+ ED++++G N +EW+Y + + +
Sbjct: 2033 VRVQESSCPLAQQPQAYLNGCRAPYSLDAEDMADYGEGWNATTLSEWQYQSQDQRQGYPI 2092
Query: 189 WGFLGVYRNGGYIFTLSKSKSETKNKFIDLRLNSWITRGTRVIFIDFSLYNANVNLFCII 248
WG L VYR GGY+ L + T L N+W+ TR +F++ ++YNANVNLFCI+
Sbjct: 2093 WGKLTVYRGGGYVVPLGTDRQSTSRILRYLFDNTWLDALTRAVFVESTVYNANVNLFCIV 2152
Query: 249 RLVAEFPATGGILTSWQFYSVKLLRYVSYYDYFIASCEITFCIFLFVFTTQEVKKIKEFK 308
L E A G T S++L + + F+ + E+ + +FL + + K++ +
Sbjct: 2153 TLTLETSALGTFFTHAALQSLRLYPFTDGWHPFVVAAELIYFLFLLYYMVVQGKRMSKET 2212
Query: 309 SAYFKSIWNWLELLLLLLCFVAVSFNTYYNVQIFLLLGQLLKSTEKYSDFYFLACWHIYY 368
YF S WN LEL ++L + A++ V L + E+ F A
Sbjct: 2213 WGYFCSKWNLLELAIILASWSALAVFVKRAVLAERDLQRCRNHREEGISFSETAAADAAL 2272
Query: 369 NNIIAITIFFAWIKIFKFISFNKTMSQLSSTLSRCVKDIVGFAIMFFIIFFAYAQLGFLV 428
IIA + + +K++ + N M+ +++ L R DI GF I+ + AY+ L+
Sbjct: 2273 GYIIAFLVLLSTVKLWHLLRLNPKMNMITAALRRAWGDISGFMIVILTMLLAYSIASNLI 2332
Query: 429 FGSQVDDFSTFQNSIFAQFRIVLGDFNFAGIQQANPILGPIYFITFIFFVFFVLLNMFLA 488
FG ++ + T ++ + LG FN+ + +P+LG + I F+ FV+LN+F++
Sbjct: 2333 FGWKLRSYKTLFDAAETMVSLQLGIFNYEEVLDYSPVLGSFLIGSCIVFMTFVVLNLFIS 2392
Query: 489 IINDTYSEVKADYSIGRRLDFELGKMIKQSYKNVLEKFRLKKAQKDEDKKTKGSGDLAE 547
+I +SE + Y + E G+++ +L +K +++ + G L++
Sbjct: 2393 VILVAFSEEQKYYQLS-----EEGEIVDLLLMKILSFLGIKSKREEPGSSREQPGSLSQ 2446
>gi|5174633 receptor for egg jelly-like protein precursor [Homo
sapiens]
Length = 2253
Score = 110 bits (276), Expect = 3e-24
Identities = 110/494 (22%), Positives = 209/494 (42%), Gaps = 49/494 (9%)
Query: 29 LQELLLYFIFLINLCILTFGMVNPHMYYLNKVMSSLFLDTSVPGEERTNFKSIRSITDFW 88
L +L +FIFL L IL + + +Y N+ + F + ++ + D +
Sbjct: 1711 LSYILTHFIFLALLLILIVLLRHTDCFYYNQFIRDRF---------SMDLATVTKLEDIY 1761
Query: 89 KFMEGPLLEGLYWDSWYNNQQLYNLKNSSRIYYENILLGVPRVRQLKVRNNT--CKVYSS 146
+++ LL L+ D + ++SS+I LG+P +RQ++ +++ C
Sbjct: 1762 RWLNSVLLPLLHNDL----NPTFLPESSSKI------LGLPLMRQVRAKSSEKMCLPAEK 1811
Query: 147 F--QSLMSE--CYGKYTSANEDLSNF-GLQINTEWRYSTSNTN--------SPW---HWG 190
F S+ E C+ KY ED N+ G + + +TN + W +G
Sbjct: 1812 FVQNSIRREIHCHPKYGIDPEDTKNYSGFWNEVDKQAIDESTNGFTYKPQGTQWLYYSYG 1871
Query: 191 FLGVYRNGGYI--FTLSKSKSETKNKFIDLRLNSWITRGTRVIFIDFSLYNANVNLFCII 248
L Y +GGY F + + + + +L+ ++W+ T + ++ + +N ++NLFC I
Sbjct: 1872 LLHTYGSGGYALYFFPEQQRFNSTLRLKELQESNWLDEKTWAVVLELTTFNPDINLFCSI 1931
Query: 249 RLVAEFPATGGILTSWQFYSVKLLRYVSYYDYFIASCEI----TFCIFLFVFTTQEVKKI 304
++ E G + TS +S L + AS EI IF + E I
Sbjct: 1932 SVIFEVSQLGVVNTSISLHSFSLADFDRK-----ASAEIYLYVAILIFFLAYVVDEGCII 1986
Query: 305 KEFKSAYFKSIWNWLELLLLLLCFVAVSFNTYYNVQIFLLLGQLLKSTEKYSDFYFLACW 364
+ +++Y +S++N L L + V + + ++ L + E + F+ ++
Sbjct: 1987 MQERASYVRSVYNLLNFALKCIFTVLIVLFLRKHFLATGIIRFYLSNPEDFIPFHAVSQV 2046
Query: 365 HIYYNNIIAITIFFAWIKIFKFISFNKTMSQLSSTLSRCVKDIVGFAIMFFIIFFAYAQL 424
I+ +F +K ++ F + + + I A + + FF Y
Sbjct: 2047 DHIMRIILGFLLFLTILKTLRYSRFFYDVRLAQRAIQAALPGICHMAFVVSVYFFVYMAF 2106
Query: 425 GFLVFGSQVDDFSTFQNSIFAQFRIVLGDFNFAGIQQANPILGPIYFITFIFFVFFVLLN 484
G+LVFG ++S +S F + F N ILG ++ +F+ + VL+N
Sbjct: 2107 GYLVFGQHEWNYSNLIHSTQTVFSYCVSAFQNTEFSN-NRILGVLFLSSFMLVMICVLIN 2165
Query: 485 MFLAIINDTYSEVK 498
+F A+I Y E+K
Sbjct: 2166 LFQAVILSAYEEMK 2179
>gi|205360962 polycystin 1 isoform 2 precursor [Homo sapiens]
Length = 4302
Score = 84.3 bits (207), Expect = 3e-16
Identities = 92/429 (21%), Positives = 170/429 (39%), Gaps = 51/429 (11%)
Query: 20 RKEVEITTTLQELLLYFIFLINLCILTFGMVNPHMYYLNKVMSSLFLDTSVPGEERTN-F 78
RK + L+ LL+Y +FL+ + ++G + H + L +++ E + F
Sbjct: 3661 RKVKRLHGMLRSLLVYMLFLLVTLLASYGDASCHGHAYR-------LQSAIKQELHSRAF 3713
Query: 79 KSIRSITDFWKFMEGPLLEGLYWDSWYNNQQLYNLKNSSRIYYENILLGVPRVRQLKV-- 136
+I + W +M LL ++ NQ L G PR+RQ+++
Sbjct: 3714 LAITRSEELWPWMAHVLLPYVH-----GNQSSPEL-------------GPPRLRQVRLQE 3755
Query: 137 ---------RNNTCKVYSSFQSLMSECYGKYTSANEDLSNFGLQINTEWRYSTSNTNSPW 187
R +TC F + Y E N + W YS + W
Sbjct: 3756 ALYPDPPGPRVHTCSAAGGFST------SDYDVGWESPHNG----SGTWAYSAPDLLGAW 3805
Query: 188 HWGFLGVYRNGGYIFTLSKSKSETKNKFIDLRLNSWITRGTRVIFIDFSLYNANVNLFCI 247
WG VY +GGY+ L S E++++ L+L++W+ +R +F++ + Y+ V L
Sbjct: 3806 SWGSCAVYDSGGYVQELGLSLEESRDRLRFLQLHNWLDNRSRAVFLELTRYSPAVGLHAA 3865
Query: 248 IRLVAEFPATGGILT--SWQFYSVKLLRYVSYYDYFIASCEITFCIFLFVFTTQEVKKIK 305
+ L EFPA G L S + ++++ L + C + F + V + +
Sbjct: 3866 VTLRLEFPAAGRALAALSVRPFALRRLSAGLSLPLLTSVCLLLFAVHFAVAEARTWHREG 3925
Query: 306 EFKSAYFKSIWNWLELLLLLLCFVAVSFNTYYNVQIFLLLGQLLKSTEKYSDFYFLACWH 365
++ + W LL+ L A+ + +++ F +A
Sbjct: 3926 RWRVLRLGAWARW--LLVALTAATALVRLAQLGAADRQWTRFVRGRPRRFTSFDQVAQLS 3983
Query: 366 IYYNNIIAITIFFAWIKIFKFISFNKTMSQLSSTLSRCVKDIVGFAIMFFIIFFAYAQLG 425
+ A +F +K + + F + S TL R + +++G + ++ AYAQL
Sbjct: 3984 SAARGLAASLLFLLLVKAAQQLRFVRQWSVFGKTLCRALPELLGVTLGLVVLGVAYAQLA 4043
Query: 426 FLVFGSQVD 434
L+ S VD
Sbjct: 4044 ILLVSSCVD 4052
>gi|205360954 polycystin 1 isoform 1 precursor [Homo sapiens]
Length = 4303
Score = 84.3 bits (207), Expect = 3e-16
Identities = 92/429 (21%), Positives = 170/429 (39%), Gaps = 51/429 (11%)
Query: 20 RKEVEITTTLQELLLYFIFLINLCILTFGMVNPHMYYLNKVMSSLFLDTSVPGEERTN-F 78
RK + L+ LL+Y +FL+ + ++G + H + L +++ E + F
Sbjct: 3662 RKVKRLHGMLRSLLVYMLFLLVTLLASYGDASCHGHAYR-------LQSAIKQELHSRAF 3714
Query: 79 KSIRSITDFWKFMEGPLLEGLYWDSWYNNQQLYNLKNSSRIYYENILLGVPRVRQLKV-- 136
+I + W +M LL ++ NQ L G PR+RQ+++
Sbjct: 3715 LAITRSEELWPWMAHVLLPYVH-----GNQSSPEL-------------GPPRLRQVRLQE 3756
Query: 137 ---------RNNTCKVYSSFQSLMSECYGKYTSANEDLSNFGLQINTEWRYSTSNTNSPW 187
R +TC F + Y E N + W YS + W
Sbjct: 3757 ALYPDPPGPRVHTCSAAGGFST------SDYDVGWESPHNG----SGTWAYSAPDLLGAW 3806
Query: 188 HWGFLGVYRNGGYIFTLSKSKSETKNKFIDLRLNSWITRGTRVIFIDFSLYNANVNLFCI 247
WG VY +GGY+ L S E++++ L+L++W+ +R +F++ + Y+ V L
Sbjct: 3807 SWGSCAVYDSGGYVQELGLSLEESRDRLRFLQLHNWLDNRSRAVFLELTRYSPAVGLHAA 3866
Query: 248 IRLVAEFPATGGILT--SWQFYSVKLLRYVSYYDYFIASCEITFCIFLFVFTTQEVKKIK 305
+ L EFPA G L S + ++++ L + C + F + V + +
Sbjct: 3867 VTLRLEFPAAGRALAALSVRPFALRRLSAGLSLPLLTSVCLLLFAVHFAVAEARTWHREG 3926
Query: 306 EFKSAYFKSIWNWLELLLLLLCFVAVSFNTYYNVQIFLLLGQLLKSTEKYSDFYFLACWH 365
++ + W LL+ L A+ + +++ F +A
Sbjct: 3927 RWRVLRLGAWARW--LLVALTAATALVRLAQLGAADRQWTRFVRGRPRRFTSFDQVAQLS 3984
Query: 366 IYYNNIIAITIFFAWIKIFKFISFNKTMSQLSSTLSRCVKDIVGFAIMFFIIFFAYAQLG 425
+ A +F +K + + F + S TL R + +++G + ++ AYAQL
Sbjct: 3985 SAARGLAASLLFLLLVKAAQQLRFVRQWSVFGKTLCRALPELLGVTLGLVVLGVAYAQLA 4044
Query: 426 FLVFGSQVD 434
L+ S VD
Sbjct: 4045 ILLVSSCVD 4053
>gi|19923084 polycystin-1L1 [Homo sapiens]
Length = 2849
Score = 78.2 bits (191), Expect = 2e-14
Identities = 94/414 (22%), Positives = 167/414 (40%), Gaps = 30/414 (7%)
Query: 20 RKEVEITTTLQELLLYFIFLINLCILTFGMVNPHMYYLNKVMSSLFLDTSVPGEERTNFK 79
R+E L+++ + + L+ L + +G + Y LN+ + F + R
Sbjct: 2275 RRESRTRAALRDISMDILMLLLLLCVIYGRFSQDEYSLNQAIRKEFTRNA-----RNCLG 2329
Query: 80 SIRSITDFWKFMEGPLLEGLYWDSWYNNQQLYNLKNSSRIYYENILLGVPRVRQLKV-RN 138
+R+I D+W + LL+GLY + + + + L+G +RQLKV
Sbjct: 2330 GLRNIADWWDWSLTTLLDGLYPGGTPSAR--VPGAQPGALGGKCYLIGSSVIRQLKVFPR 2387
Query: 139 NTCKVYSSFQSLMSECYGKYTSANEDLSNFGLQINTEWRYSTSNTNSPWHWGFLGVYRNG 198
+ CK F +L+ + + N L I+ E + T N G G
Sbjct: 2388 HLCKPPRPFSALIEDSIPTCSPEVGGPENPYL-IDPENQNVTLN-------GPGGCGTRE 2439
Query: 199 GYIFTLSKSKSETKNKFIDLRLNSWITRGTRVIFIDFSLYNANVNLFCIIRLVAEFPATG 258
+ +L ++++E LR + WI R TR + + F+LYN LF + L E TG
Sbjct: 2440 DCVLSLGRTRTEAHTALSRLRASMWIDRSTRAVSVHFTLYNPPTQLFTSVSLRVEILPTG 2499
Query: 259 GILTSWQFYSVKLLRYVSYYDYFIASCEITF-CIFLFVFTTQEVKKIKEFKSAYFKSIWN 317
++ S S + R S Y + ++ F + L Q + + + +Y++ N
Sbjct: 2500 SLVPSSLVESFSIFRSDSALQYHLMLPQLVFLALSLIHLCVQLYRMMDKGVLSYWRKPRN 2559
Query: 318 WLELLLLLLCFVAVSFNTYYNV--QIFLLLGQLLKSTEK-----YSDFYFLACWHIYYNN 370
WLEL + V VS TYY V + L G + + + D +A W+
Sbjct: 2560 WLELSV-----VGVSL-TYYAVSGHLVTLAGDVTNQFHRGLCRAFMDLTLMASWNQRARW 2613
Query: 371 IIAITIFFAWIKIFKFISFNKTMSQLSSTLSRCVKDIVGFAIMFFIIFFAYAQL 424
+ I +F +K TM+ SS + + I ++ ++ A + L
Sbjct: 2614 LRGILLFLFTLKCVYLPGIQNTMASCSSMMRHSLPSIFVAGLVGALMLAALSHL 2667
>gi|239756622 PREDICTED: polycystic kidney disease 1-like 3 [Homo
sapiens]
Length = 1732
Score = 67.0 bits (162), Expect = 5e-11
Identities = 40/201 (19%), Positives = 94/201 (46%), Gaps = 4/201 (1%)
Query: 290 CIFLFVFTTQEVKKIKEFKSAYFKSIWNWLELLLLLLCFVAVSFNTYYNVQIFLLLGQLL 349
C + F+ Q +K+ K +F N L+ ++L+ F+ + + + +
Sbjct: 1478 CYYAFIQGCQ----LKQQKWRFFTGKRNILDTSIILISFILLGLDMKSISLHKKNMARYR 1533
Query: 350 KSTEKYSDFYFLACWHIYYNNIIAITIFFAWIKIFKFISFNKTMSQLSSTLSRCVKDIVG 409
+++ FY + +++ + A ++++ + + + +S TLSR ++VG
Sbjct: 1534 DDQDRFISFYEAVKVNSAATHLVGFPVLLATVQLWNLLRHSPRLRVISRTLSRAWDEVVG 1593
Query: 410 FAIMFFIIFFAYAQLGFLVFGSQVDDFSTFQNSIFAQFRIVLGDFNFAGIQQANPILGPI 469
F ++ I+ YA L+FG + D+ TF +S +++G + + +P+LG
Sbjct: 1594 FLLIILILLTGYAIAFNLLFGCSISDYRTFFSSAVTVVGLLMGISHQEEVFALDPVLGTF 1653
Query: 470 YFITFIFFVFFVLLNMFLAII 490
+T + + V++N+F++ I
Sbjct: 1654 LILTSVILMVLVVINLFVSAI 1674
>gi|239751108 PREDICTED: polycystic kidney disease 1-like 3 [Homo
sapiens]
Length = 1731
Score = 67.0 bits (162), Expect = 5e-11
Identities = 40/201 (19%), Positives = 94/201 (46%), Gaps = 4/201 (1%)
Query: 290 CIFLFVFTTQEVKKIKEFKSAYFKSIWNWLELLLLLLCFVAVSFNTYYNVQIFLLLGQLL 349
C + F+ Q +K+ K +F N L+ ++L+ F+ + + + +
Sbjct: 1477 CYYAFIQGCQ----LKQQKWRFFTGKRNILDTSIILISFILLGLDMKSISLHKKNMARYR 1532
Query: 350 KSTEKYSDFYFLACWHIYYNNIIAITIFFAWIKIFKFISFNKTMSQLSSTLSRCVKDIVG 409
+++ FY + +++ + A ++++ + + + +S TLSR ++VG
Sbjct: 1533 DDQDRFISFYEAVKVNSAATHLVGFPVLLATVQLWNLLRHSPRLRVISRTLSRAWDEVVG 1592
Query: 410 FAIMFFIIFFAYAQLGFLVFGSQVDDFSTFQNSIFAQFRIVLGDFNFAGIQQANPILGPI 469
F ++ I+ YA L+FG + D+ TF +S +++G + + +P+LG
Sbjct: 1593 FLLIILILLTGYAIAFNLLFGCSISDYRTFFSSAVTVVGLLMGISHQEEVFALDPVLGTF 1652
Query: 470 YFITFIFFVFFVLLNMFLAII 490
+T + + V++N+F++ I
Sbjct: 1653 LILTSVILMVLVVINLFVSAI 1673
>gi|239745596 PREDICTED: polycystin 1-like 3 [Homo sapiens]
Length = 1731
Score = 67.0 bits (162), Expect = 5e-11
Identities = 40/201 (19%), Positives = 94/201 (46%), Gaps = 4/201 (1%)
Query: 290 CIFLFVFTTQEVKKIKEFKSAYFKSIWNWLELLLLLLCFVAVSFNTYYNVQIFLLLGQLL 349
C + F+ Q +K+ K +F N L+ ++L+ F+ + + + +
Sbjct: 1477 CYYAFIQGCQ----LKQQKWRFFTGKRNILDTSIILISFILLGLDMKSISLHKKNMARYR 1532
Query: 350 KSTEKYSDFYFLACWHIYYNNIIAITIFFAWIKIFKFISFNKTMSQLSSTLSRCVKDIVG 409
+++ FY + +++ + A ++++ + + + +S TLSR ++VG
Sbjct: 1533 DDQDRFISFYEAVKVNSAATHLVGFPVLLATVQLWNLLRHSPRLRVISRTLSRAWDEVVG 1592
Query: 410 FAIMFFIIFFAYAQLGFLVFGSQVDDFSTFQNSIFAQFRIVLGDFNFAGIQQANPILGPI 469
F ++ I+ YA L+FG + D+ TF +S +++G + + +P+LG
Sbjct: 1593 FLLIILILLTGYAIAFNLLFGCSISDYRTFFSSAVTVVGLLMGISHQEEVFALDPVLGTF 1652
Query: 470 YFITFIFFVFFVLLNMFLAII 490
+T + + V++N+F++ I
Sbjct: 1653 LILTSVILMVLVVINLFVSAI 1673
>gi|31559825 polycystin 1-like 3 [Homo sapiens]
Length = 1732
Score = 67.0 bits (162), Expect = 5e-11
Identities = 40/201 (19%), Positives = 94/201 (46%), Gaps = 4/201 (1%)
Query: 290 CIFLFVFTTQEVKKIKEFKSAYFKSIWNWLELLLLLLCFVAVSFNTYYNVQIFLLLGQLL 349
C + F+ Q +K+ K +F N L+ ++L+ F+ + + + +
Sbjct: 1478 CYYAFIQGCQ----LKQQKWRFFTGKRNILDTSIILISFILLGLDMKSISLHKKNMARYR 1533
Query: 350 KSTEKYSDFYFLACWHIYYNNIIAITIFFAWIKIFKFISFNKTMSQLSSTLSRCVKDIVG 409
+++ FY + +++ + A ++++ + + + +S TLSR ++VG
Sbjct: 1534 DDQDRFISFYEAVKVNSAATHLVGFPVLLATVQLWNLLRHSPRLRVISRTLSRAWDEVVG 1593
Query: 410 FAIMFFIIFFAYAQLGFLVFGSQVDDFSTFQNSIFAQFRIVLGDFNFAGIQQANPILGPI 469
F ++ I+ YA L+FG + D+ TF +S +++G + + +P+LG
Sbjct: 1594 FLLIILILLTGYAIAFNLLFGCSISDYRTFFSSAVTVVGLLMGISHQEEVFALDPVLGTF 1653
Query: 470 YFITFIFFVFFVLLNMFLAII 490
+T + + V++N+F++ I
Sbjct: 1654 LILTSVILMVLVVINLFVSAI 1674
>gi|53832011 calcium channel, voltage-dependent, T type, alpha 1H
subunit isoform b [Homo sapiens]
Length = 2347
Score = 65.9 bits (159), Expect = 1e-10
Identities = 57/256 (22%), Positives = 103/256 (40%), Gaps = 57/256 (22%)
Query: 291 IFLFVFTTQEVKKIKEFK-SAYFKSIWNWLELLLLLLCFVAVSFNTYYNVQIFLLLGQLL 349
+F VF + K+ F +FK WN L+L ++LL + ++ +I + +
Sbjct: 1649 VFTIVFVFEAALKLVAFGFRRFFKDRWNQLDLAIVLLSLMGITLE-----EIEMSAALPI 1703
Query: 350 KSTEKYSDFYFLACWHIYYNNIIAITIFFAWIKIFKFISFNKTMSQLSSTLSRCVKDIVG 409
T II I ++ K + M L T+ + + +
Sbjct: 1704 NPT------------------IIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGN 1745
Query: 410 FAIMFFIIFFAYAQLGFLVFG-------------SQVDDFSTFQNSIFAQFRIVLGDFNF 456
++F ++FF YA LG +FG S+ FS F + FR+ GD N+
Sbjct: 1746 LGLLFMLLFFIYAALGVELFGRLECSEDNPCEGLSRHATFSNFGMAFLTLFRVSTGD-NW 1804
Query: 457 AGIQQAN---------------PILGPIYFITFIFFVFFVLLNMFLAI----INDTYSEV 497
GI + P L P+YF+TF+ FVL+N+ +A+ + ++ E
Sbjct: 1805 NGIMKDTLRECSREDKHCLSYLPALSPVYFVTFVLVAQFVLVNVVVAVLMKHLEESNKEA 1864
Query: 498 KADYSIGRRLDFELGK 513
+ D + ++ E+ +
Sbjct: 1865 REDAELDAEIELEMAQ 1880
Score = 32.7 bits (73), Expect = 1.0
Identities = 38/214 (17%), Positives = 83/214 (38%), Gaps = 40/214 (18%)
Query: 299 QEVKKIKEFKSAYFKSIWNWLELLLLLLCFVAVSFNTYYNVQIFLLLGQLLKSTEKYSDF 358
+E+ E + F S++ LL LL C YN+ +++
Sbjct: 819 EELTNALEISNIVFTSMFALEMLLKLLACGPLGYIRNPYNIFDGIIV------------- 865
Query: 359 YFLACWHIY--YNNIIAITIFFAWIKIFKFISFNKTMSQLSSTLSRCVKDIVGFAIMFFI 416
++ W I + +++ F +++ K + F + + L + + ++ F + +
Sbjct: 866 -VISVWEIVGQADGGLSVLRTFRLLRVLKLVRFLPALRRQLVVLVKTMDNVATFCTLLML 924
Query: 417 IFFAYAQLGFLVFGSQ----------VDDFSTFQNSIFAQFRIVLGDFNFAGIQQANPIL 466
F ++ LG +FG + V D F + ++A ++ F + N +L
Sbjct: 925 FIFIFSILGMHLFGCKFSLKTDTGDTVPDRKNFDSLLWA----IVTVFQILTQEDWNVVL 980
Query: 467 ----------GPIYFITFIFFVFFVLLNMFLAII 490
+YF+ + F +VL N+ +AI+
Sbjct: 981 YNGMASTSSWAALYFVALMTFGNYVLFNLLVAIL 1014
Score = 31.6 bits (70), Expect = 2.2
Identities = 13/40 (32%), Positives = 26/40 (65%), Gaps = 1/40 (2%)
Query: 459 IQQANPILGPIYFITFIFFVFFVLLNMFLAIINDTYSEVK 498
+Q NP + +YFI+F+ V F +LNMF+ ++ + + + +
Sbjct: 1524 VQNHNPWM-LLYFISFLLIVSFFVLNMFVGVVVENFHKCR 1562
>gi|53832009 calcium channel, voltage-dependent, T type, alpha 1H
subunit isoform a [Homo sapiens]
Length = 2353
Score = 65.9 bits (159), Expect = 1e-10
Identities = 57/256 (22%), Positives = 103/256 (40%), Gaps = 57/256 (22%)
Query: 291 IFLFVFTTQEVKKIKEFK-SAYFKSIWNWLELLLLLLCFVAVSFNTYYNVQIFLLLGQLL 349
+F VF + K+ F +FK WN L+L ++LL + ++ +I + +
Sbjct: 1655 VFTIVFVFEAALKLVAFGFRRFFKDRWNQLDLAIVLLSLMGITLE-----EIEMSAALPI 1709
Query: 350 KSTEKYSDFYFLACWHIYYNNIIAITIFFAWIKIFKFISFNKTMSQLSSTLSRCVKDIVG 409
T II I ++ K + M L T+ + + +
Sbjct: 1710 NPT------------------IIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGN 1751
Query: 410 FAIMFFIIFFAYAQLGFLVFG-------------SQVDDFSTFQNSIFAQFRIVLGDFNF 456
++F ++FF YA LG +FG S+ FS F + FR+ GD N+
Sbjct: 1752 LGLLFMLLFFIYAALGVELFGRLECSEDNPCEGLSRHATFSNFGMAFLTLFRVSTGD-NW 1810
Query: 457 AGIQQAN---------------PILGPIYFITFIFFVFFVLLNMFLAI----INDTYSEV 497
GI + P L P+YF+TF+ FVL+N+ +A+ + ++ E
Sbjct: 1811 NGIMKDTLRECSREDKHCLSYLPALSPVYFVTFVLVAQFVLVNVVVAVLMKHLEESNKEA 1870
Query: 498 KADYSIGRRLDFELGK 513
+ D + ++ E+ +
Sbjct: 1871 REDAELDAEIELEMAQ 1886
Score = 32.7 bits (73), Expect = 1.0
Identities = 38/214 (17%), Positives = 83/214 (38%), Gaps = 40/214 (18%)
Query: 299 QEVKKIKEFKSAYFKSIWNWLELLLLLLCFVAVSFNTYYNVQIFLLLGQLLKSTEKYSDF 358
+E+ E + F S++ LL LL C YN+ +++
Sbjct: 819 EELTNALEISNIVFTSMFALEMLLKLLACGPLGYIRNPYNIFDGIIV------------- 865
Query: 359 YFLACWHIY--YNNIIAITIFFAWIKIFKFISFNKTMSQLSSTLSRCVKDIVGFAIMFFI 416
++ W I + +++ F +++ K + F + + L + + ++ F + +
Sbjct: 866 -VISVWEIVGQADGGLSVLRTFRLLRVLKLVRFLPALRRQLVVLVKTMDNVATFCTLLML 924
Query: 417 IFFAYAQLGFLVFGSQ----------VDDFSTFQNSIFAQFRIVLGDFNFAGIQQANPIL 466
F ++ LG +FG + V D F + ++A ++ F + N +L
Sbjct: 925 FIFIFSILGMHLFGCKFSLKTDTGDTVPDRKNFDSLLWA----IVTVFQILTQEDWNVVL 980
Query: 467 ----------GPIYFITFIFFVFFVLLNMFLAII 490
+YF+ + F +VL N+ +AI+
Sbjct: 981 YNGMASTSSWAALYFVALMTFGNYVLFNLLVAIL 1014
Score = 31.6 bits (70), Expect = 2.2
Identities = 13/40 (32%), Positives = 26/40 (65%), Gaps = 1/40 (2%)
Query: 459 IQQANPILGPIYFITFIFFVFFVLLNMFLAIINDTYSEVK 498
+Q NP + +YFI+F+ V F +LNMF+ ++ + + + +
Sbjct: 1524 VQNHNPWM-LLYFISFLLIVSFFVLNMFVGVVVENFHKCR 1562
>gi|192807298 calcium channel, voltage-dependent, L type, alpha 1D
subunit isoform c [Homo sapiens]
Length = 2137
Score = 62.8 bits (151), Expect = 9e-10
Identities = 56/256 (21%), Positives = 104/256 (40%), Gaps = 60/256 (23%)
Query: 281 FIASCEITFCIFLFVFTTQEVKKIKEFK-SAYFKSIWNWLELLLLLLCFVAVSFNTYYNV 339
F + +I +F VFT + V K+ FK YF WN + L+++ + V+ + N
Sbjct: 1233 FNDAMDILNMVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVALSEADNS 1292
Query: 340 QIFLLLGQLLKSTEKYSDFYFLACWHIYYNNIIAITIF--FAWIKIFKFISFNKTMSQLS 397
+ +N I+IT F F +++ K +S + + L
Sbjct: 1293 E---------------------------ESNRISITFFRLFRVMRLVKLLSRGEGIRTLL 1325
Query: 398 STLSRCVKDIVGFAIMFFIIFFAYAQLGFLVFG----------SQVDDFSTFQNSIFAQF 447
T + + + A++ ++FF YA +G +FG ++ ++F TF ++ F
Sbjct: 1326 WTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLLLF 1385
Query: 448 RIVLG--------------------DFNFAGIQQANPILGPIYFITFIFFVFFVLLNMFL 487
R G D+N +YFI+F F+++N+F+
Sbjct: 1386 RCATGEAWQEIMLACLPGKLCDPESDYNPGEEYTCGSNFAIVYFISFYMLCAFLIINLFV 1445
Query: 488 AIINDTYSEVKADYSI 503
A+I D + + D+SI
Sbjct: 1446 AVIMDNFDYLTRDWSI 1461
Score = 47.4 bits (111), Expect = 4e-05
Identities = 51/228 (22%), Positives = 98/228 (42%), Gaps = 39/228 (17%)
Query: 381 IKIFKFISFNKTMSQLSSTLSRCVKDIVGFAIMFFIIFFAYAQLGFLVFGSQVD------ 434
++IFK ++S L ++L +K I ++ F+ ++ LG +FG + +
Sbjct: 624 LRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQT 683
Query: 435 ---DFSTFQNSIFAQFRIVLG-DFN---FAGIQ-----QANPILGPIYFITFIFFVFFVL 482
F F ++ F+I+ G D+N + GI ++ ++ IYFI ++L
Sbjct: 684 KRSTFDNFPQALLTVFQILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYIL 743
Query: 483 LNMFLAIINDTYSEVKADYSIGRRLDFELGKMIKQSYKNVLEKFRLKK------------ 530
LN+FLAI D ++ ++ + ++ + E + K + K LE + K
Sbjct: 744 LNVFLAIAVDNLADAES-LNTAQKEEAEEKERKKIARKESLENKKNNKPEVNQIANSDNK 802
Query: 531 ------AQKDEDKKTKGSGD--LAEQARREGFDENEIQNAEQMKKWKE 570
++DEDK D + E+ E DE E+ + ++ E
Sbjct: 803 VTIDDYREEDEDKDPYPPCDVPVGEEEEEEEEDEPEVPAGPRPRRISE 850
>gi|20070163 voltage-dependent calcium channel alpha 1G subunit
isoform 1 [Homo sapiens]
Length = 2377
Score = 62.0 bits (149), Expect = 2e-09
Identities = 56/259 (21%), Positives = 103/259 (39%), Gaps = 54/259 (20%)
Query: 291 IFLFVFTTQEVKKIKEFK-SAYFKSIWNWLELLLLLLCFVAVSFNTYYNVQIFLLLGQLL 349
IF +F + V K+ F +F+ WN L+L ++LL + ++ V L +
Sbjct: 1649 IFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEI-EVNASLPINP-- 1705
Query: 350 KSTEKYSDFYFLACWHIYYNNIIAITIFFAWIKIFKFISFNKTMSQLSSTLSRCVKDIVG 409
II I ++ K + M L T+ + + +
Sbjct: 1706 --------------------TIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGN 1745
Query: 410 FAIMFFIIFFAYAQLGFLVFGSQVDD-------------FSTFQNSIFAQFRIVLGDFNF 456
++F ++FF +A LG +FG D F F + FR+ GD N+
Sbjct: 1746 LGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGD-NW 1804
Query: 457 AGIQQA------------NPILGPIYFITFIFFVFFVLLNMFLAI----INDTYSEVKAD 500
GI + N ++ PIYF++F+ FVL+N+ +A+ + ++ E K +
Sbjct: 1805 NGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEE 1864
Query: 501 YSIGRRLDFELGKMIKQSY 519
+ L+ E+ + Q +
Sbjct: 1865 AELEAELELEMKTLSPQPH 1883
Score = 33.5 bits (75), Expect = 0.59
Identities = 47/254 (18%), Positives = 90/254 (35%), Gaps = 71/254 (27%)
Query: 291 IFLFVFTTQEVKKIKEF-----KSAYFKSIWNWLELLLLLLCFVAVSFNTYYNVQIFLLL 345
IF VF + K+ + AY +S WN L+ LL+L+ + + L+
Sbjct: 1316 IFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDI------------LV 1363
Query: 346 GQLLKSTEKYSDFYFLACWHIYYNNIIAITIFFAWIKIFKFISFNKTMSQLSSTLSRCVK 405
+ S K ++ + ++ + IS + + + TL +K
Sbjct: 1364 SMVSDSGTKIL-------------GMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLK 1410
Query: 406 DIVGFAIMFFIIFFAYAQLGFLVF--------GSQVDDFSTFQNSIFAQFRIVLGDFNFA 457
I ++ F + LG +F G + + + A +R V +NF
Sbjct: 1411 PIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRHKYNFD 1470
Query: 458 GIQQA----------------------------NPILGP-----IYFITFIFFVFFVLLN 484
+ QA PI+ +YFI+F+ V F +LN
Sbjct: 1471 NLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLN 1530
Query: 485 MFLAIINDTYSEVK 498
MF+ ++ + + + +
Sbjct: 1531 MFVGVVVENFHKCR 1544
Score = 33.1 bits (74), Expect = 0.77
Identities = 25/132 (18%), Positives = 56/132 (42%), Gaps = 23/132 (17%)
Query: 378 FAWIKIFKFISFNKTMSQLSSTLSRCVKDIVGFAIMFFIIFFAYAQLGFLVFGSQ----- 432
F +++ K + F + + L + + ++ F ++ + F ++ LG +FG +
Sbjct: 836 FRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASER 895
Query: 433 ----VDDFSTFQNSIFAQFRIVLGDFNFAGIQQANPIL----------GPIYFITFIFFV 478
+ D F + ++A ++ F + N +L +YFI + F
Sbjct: 896 DGDTLPDRKNFDSLLWA----IVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFG 951
Query: 479 FFVLLNMFLAII 490
+VL N+ +AI+
Sbjct: 952 NYVLFNLLVAIL 963
>gi|187828892 calcium channel, alpha 1A subunit isoform 4 [Homo
sapiens]
Length = 2506
Score = 62.0 bits (149), Expect = 2e-09
Identities = 62/253 (24%), Positives = 110/253 (43%), Gaps = 35/253 (13%)
Query: 381 IKIFKFISFNKTMSQLSSTLSRCVKDIVGFAIMFFIIFFAYAQLGFLVFGSQVD------ 434
++IFK + ++ L +L +K I+ + F+ +A LG +FG Q +
Sbjct: 587 LRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFDEGTP 646
Query: 435 --DFSTFQNSIFAQFRIVLG-DFN---FAGIQQANPILG----PIYFITFIFFVFFVLLN 484
+F TF +I F+I+ G D+N + GI+ + G IYFI F + LLN
Sbjct: 647 PTNFDTFPAAIMTVFQILTGEDWNEVMYDGIKSQGGVQGGMVFSIYFIVLTLFGNYTLLN 706
Query: 485 MFLAIIND--------TYSEVKADYSIGRRLDFELGKMIKQSYKNVLEKFRLKKAQKDED 536
+FLAI D T E + + + ++L + K + + + L + A K++
Sbjct: 707 VFLAIAVDNLANAQELTKDEQEEEEAANQKLALQKAKEVAE--VSPLSAANMSIAVKEQQ 764
Query: 537 KKTKGSGDLAEQARREGFDENEIQNAEQMKKWKERLE--KKYYSMEIQDDYQP------- 587
K K + + EQ E +N + + E + + E K Y+ ++ D +
Sbjct: 765 KNQKPAKSVWEQRTSEMRKQNLLASREALYNEMDPDERWKAAYTRHLRPDMKTHLDRPLV 824
Query: 588 VTQEEFRDGTTTK 600
V +E R+ T K
Sbjct: 825 VDPQENRNNNTNK 837
Score = 45.8 bits (107), Expect = 1e-04
Identities = 40/172 (23%), Positives = 72/172 (41%), Gaps = 37/172 (21%)
Query: 369 NNIIAITIF--FAWIKIFKFISFNKTMSQLSSTLSRCVKDIVGFAIMFFIIFFAYAQLGF 426
NN I ++ F ++ K + T+ L T + K + ++ ++FF YA +G
Sbjct: 1651 NNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGM 1710
Query: 427 LVFGS------------------QVDDFSTFQNSIFAQFRIVLGDF-------------- 454
VFG+ + ++F TF ++ FR G+
Sbjct: 1711 QVFGNIGIDVEDEDSDEDEFQITEHNNFRTFFQALMLLFRSATGEAWHNIMLSCLSGKPC 1770
Query: 455 -NFAGI--QQANPILGPIYFITFIFFVFFVLLNMFLAIINDTYSEVKADYSI 503
+GI ++ YF++FIF F++LN+F+A+I D + + D SI
Sbjct: 1771 DKNSGILTRECGNEFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSI 1822
>gi|187828880 calcium channel, alpha 1A subunit isoform 3 [Homo
sapiens]
Length = 2261
Score = 62.0 bits (149), Expect = 2e-09
Identities = 62/253 (24%), Positives = 110/253 (43%), Gaps = 35/253 (13%)
Query: 381 IKIFKFISFNKTMSQLSSTLSRCVKDIVGFAIMFFIIFFAYAQLGFLVFGSQVD------ 434
++IFK + ++ L +L +K I+ + F+ +A LG +FG Q +
Sbjct: 588 LRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFDEGTP 647
Query: 435 --DFSTFQNSIFAQFRIVLG-DFN---FAGIQQANPILG----PIYFITFIFFVFFVLLN 484
+F TF +I F+I+ G D+N + GI+ + G IYFI F + LLN
Sbjct: 648 PTNFDTFPAAIMTVFQILTGEDWNEVMYDGIKSQGGVQGGMVFSIYFIVLTLFGNYTLLN 707
Query: 485 MFLAIIND--------TYSEVKADYSIGRRLDFELGKMIKQSYKNVLEKFRLKKAQKDED 536
+FLAI D T E + + + ++L + K + + + L + A K++
Sbjct: 708 VFLAIAVDNLANAQELTKDEQEEEEAANQKLALQKAKEVAE--VSPLSAANMSIAVKEQQ 765
Query: 537 KKTKGSGDLAEQARREGFDENEIQNAEQMKKWKERLE--KKYYSMEIQDDYQP------- 587
K K + + EQ E +N + + E + + E K Y+ ++ D +
Sbjct: 766 KNQKPAKSVWEQRTSEMRKQNLLASREALYNEMDPDERWKAAYTRHLRPDMKTHLDRPLV 825
Query: 588 VTQEEFRDGTTTK 600
V +E R+ T K
Sbjct: 826 VDPQENRNNNTNK 838
Score = 45.8 bits (107), Expect = 1e-04
Identities = 40/172 (23%), Positives = 72/172 (41%), Gaps = 37/172 (21%)
Query: 369 NNIIAITIF--FAWIKIFKFISFNKTMSQLSSTLSRCVKDIVGFAIMFFIIFFAYAQLGF 426
NN I ++ F ++ K + T+ L T + K + ++ ++FF YA +G
Sbjct: 1652 NNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGM 1711
Query: 427 LVFGS------------------QVDDFSTFQNSIFAQFRIVLGDF-------------- 454
VFG+ + ++F TF ++ FR G+
Sbjct: 1712 QVFGNIGIDVEDEDSDEDEFQITEHNNFRTFFQALMLLFRSATGEAWHNIMLSCLSGKPC 1771
Query: 455 -NFAGI--QQANPILGPIYFITFIFFVFFVLLNMFLAIINDTYSEVKADYSI 503
+GI ++ YF++FIF F++LN+F+A+I D + + D SI
Sbjct: 1772 DKNSGILTRECGNEFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSI 1823
>gi|38505292 voltage-dependent calcium channel alpha 1G subunit
isoform 3 [Homo sapiens]
Length = 2343
Score = 62.0 bits (149), Expect = 2e-09
Identities = 56/259 (21%), Positives = 103/259 (39%), Gaps = 54/259 (20%)
Query: 291 IFLFVFTTQEVKKIKEFK-SAYFKSIWNWLELLLLLLCFVAVSFNTYYNVQIFLLLGQLL 349
IF +F + V K+ F +F+ WN L+L ++LL + ++ V L +
Sbjct: 1615 IFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEI-EVNASLPINP-- 1671
Query: 350 KSTEKYSDFYFLACWHIYYNNIIAITIFFAWIKIFKFISFNKTMSQLSSTLSRCVKDIVG 409
II I ++ K + M L T+ + + +
Sbjct: 1672 --------------------TIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGN 1711
Query: 410 FAIMFFIIFFAYAQLGFLVFGSQVDD-------------FSTFQNSIFAQFRIVLGDFNF 456
++F ++FF +A LG +FG D F F + FR+ GD N+
Sbjct: 1712 LGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGD-NW 1770
Query: 457 AGIQQA------------NPILGPIYFITFIFFVFFVLLNMFLAI----INDTYSEVKAD 500
GI + N ++ PIYF++F+ FVL+N+ +A+ + ++ E K +
Sbjct: 1771 NGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEE 1830
Query: 501 YSIGRRLDFELGKMIKQSY 519
+ L+ E+ + Q +
Sbjct: 1831 AELEAELELEMKTLSPQPH 1849
Score = 33.5 bits (75), Expect = 0.59
Identities = 47/254 (18%), Positives = 90/254 (35%), Gaps = 71/254 (27%)
Query: 291 IFLFVFTTQEVKKIKEF-----KSAYFKSIWNWLELLLLLLCFVAVSFNTYYNVQIFLLL 345
IF VF + K+ + AY +S WN L+ LL+L+ + + L+
Sbjct: 1293 IFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDI------------LV 1340
Query: 346 GQLLKSTEKYSDFYFLACWHIYYNNIIAITIFFAWIKIFKFISFNKTMSQLSSTLSRCVK 405
+ S K ++ + ++ + IS + + + TL +K
Sbjct: 1341 SMVSDSGTKIL-------------GMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLK 1387
Query: 406 DIVGFAIMFFIIFFAYAQLGFLVF--------GSQVDDFSTFQNSIFAQFRIVLGDFNFA 457
I ++ F + LG +F G + + + A +R V +NF
Sbjct: 1388 PIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRHKYNFD 1447
Query: 458 GIQQA----------------------------NPILGP-----IYFITFIFFVFFVLLN 484
+ QA PI+ +YFI+F+ V F +LN
Sbjct: 1448 NLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLN 1507
Query: 485 MFLAIINDTYSEVK 498
MF+ ++ + + + +
Sbjct: 1508 MFVGVVVENFHKCR 1521
Score = 33.1 bits (74), Expect = 0.77
Identities = 25/132 (18%), Positives = 56/132 (42%), Gaps = 23/132 (17%)
Query: 378 FAWIKIFKFISFNKTMSQLSSTLSRCVKDIVGFAIMFFIIFFAYAQLGFLVFGSQ----- 432
F +++ K + F + + L + + ++ F ++ + F ++ LG +FG +
Sbjct: 836 FRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASER 895
Query: 433 ----VDDFSTFQNSIFAQFRIVLGDFNFAGIQQANPIL----------GPIYFITFIFFV 478
+ D F + ++A ++ F + N +L +YFI + F
Sbjct: 896 DGDTLPDRKNFDSLLWA----IVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFG 951
Query: 479 FFVLLNMFLAII 490
+VL N+ +AI+
Sbjct: 952 NYVLFNLLVAIL 963
>gi|38505290 voltage-dependent calcium channel alpha 1G subunit
isoform 13 [Homo sapiens]
Length = 2243
Score = 62.0 bits (149), Expect = 2e-09
Identities = 56/259 (21%), Positives = 103/259 (39%), Gaps = 54/259 (20%)
Query: 291 IFLFVFTTQEVKKIKEFK-SAYFKSIWNWLELLLLLLCFVAVSFNTYYNVQIFLLLGQLL 349
IF +F + V K+ F +F+ WN L+L ++LL + ++ V L +
Sbjct: 1608 IFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEI-EVNASLPINP-- 1664
Query: 350 KSTEKYSDFYFLACWHIYYNNIIAITIFFAWIKIFKFISFNKTMSQLSSTLSRCVKDIVG 409
II I ++ K + M L T+ + + +
Sbjct: 1665 --------------------TIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGN 1704
Query: 410 FAIMFFIIFFAYAQLGFLVFGSQVDD-------------FSTFQNSIFAQFRIVLGDFNF 456
++F ++FF +A LG +FG D F F + FR+ GD N+
Sbjct: 1705 LGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGD-NW 1763
Query: 457 AGIQQA------------NPILGPIYFITFIFFVFFVLLNMFLAI----INDTYSEVKAD 500
GI + N ++ PIYF++F+ FVL+N+ +A+ + ++ E K +
Sbjct: 1764 NGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEE 1823
Query: 501 YSIGRRLDFELGKMIKQSY 519
+ L+ E+ + Q +
Sbjct: 1824 AELEAELELEMKTLSPQPH 1842
Score = 33.5 bits (75), Expect = 0.59
Identities = 47/254 (18%), Positives = 90/254 (35%), Gaps = 71/254 (27%)
Query: 291 IFLFVFTTQEVKKIKEF-----KSAYFKSIWNWLELLLLLLCFVAVSFNTYYNVQIFLLL 345
IF VF + K+ + AY +S WN L+ LL+L+ + + L+
Sbjct: 1293 IFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDI------------LV 1340
Query: 346 GQLLKSTEKYSDFYFLACWHIYYNNIIAITIFFAWIKIFKFISFNKTMSQLSSTLSRCVK 405
+ S K ++ + ++ + IS + + + TL +K
Sbjct: 1341 SMVSDSGTKIL-------------GMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLK 1387
Query: 406 DIVGFAIMFFIIFFAYAQLGFLVF--------GSQVDDFSTFQNSIFAQFRIVLGDFNFA 457
I ++ F + LG +F G + + + A +R V +NF
Sbjct: 1388 PIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRHKYNFD 1447
Query: 458 GIQQA----------------------------NPILGP-----IYFITFIFFVFFVLLN 484
+ QA PI+ +YFI+F+ V F +LN
Sbjct: 1448 NLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLN 1507
Query: 485 MFLAIINDTYSEVK 498
MF+ ++ + + + +
Sbjct: 1508 MFVGVVVENFHKCR 1521
Score = 33.1 bits (74), Expect = 0.77
Identities = 25/132 (18%), Positives = 56/132 (42%), Gaps = 23/132 (17%)
Query: 378 FAWIKIFKFISFNKTMSQLSSTLSRCVKDIVGFAIMFFIIFFAYAQLGFLVFGSQ----- 432
F +++ K + F + + L + + ++ F ++ + F ++ LG +FG +
Sbjct: 836 FRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASER 895
Query: 433 ----VDDFSTFQNSIFAQFRIVLGDFNFAGIQQANPIL----------GPIYFITFIFFV 478
+ D F + ++A ++ F + N +L +YFI + F
Sbjct: 896 DGDTLPDRKNFDSLLWA----IVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFG 951
Query: 479 FFVLLNMFLAII 490
+VL N+ +AI+
Sbjct: 952 NYVLFNLLVAIL 963
>gi|38505288 voltage-dependent calcium channel alpha 1G subunit
isoform 12 [Homo sapiens]
Length = 2250
Score = 62.0 bits (149), Expect = 2e-09
Identities = 56/259 (21%), Positives = 103/259 (39%), Gaps = 54/259 (20%)
Query: 291 IFLFVFTTQEVKKIKEFK-SAYFKSIWNWLELLLLLLCFVAVSFNTYYNVQIFLLLGQLL 349
IF +F + V K+ F +F+ WN L+L ++LL + ++ V L +
Sbjct: 1615 IFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEI-EVNASLPINP-- 1671
Query: 350 KSTEKYSDFYFLACWHIYYNNIIAITIFFAWIKIFKFISFNKTMSQLSSTLSRCVKDIVG 409
II I ++ K + M L T+ + + +
Sbjct: 1672 --------------------TIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGN 1711
Query: 410 FAIMFFIIFFAYAQLGFLVFGSQVDD-------------FSTFQNSIFAQFRIVLGDFNF 456
++F ++FF +A LG +FG D F F + FR+ GD N+
Sbjct: 1712 LGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGD-NW 1770
Query: 457 AGIQQA------------NPILGPIYFITFIFFVFFVLLNMFLAI----INDTYSEVKAD 500
GI + N ++ PIYF++F+ FVL+N+ +A+ + ++ E K +
Sbjct: 1771 NGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEE 1830
Query: 501 YSIGRRLDFELGKMIKQSY 519
+ L+ E+ + Q +
Sbjct: 1831 AELEAELELEMKTLSPQPH 1849
Score = 33.5 bits (75), Expect = 0.59
Identities = 47/254 (18%), Positives = 90/254 (35%), Gaps = 71/254 (27%)
Query: 291 IFLFVFTTQEVKKIKEF-----KSAYFKSIWNWLELLLLLLCFVAVSFNTYYNVQIFLLL 345
IF VF + K+ + AY +S WN L+ LL+L+ + + L+
Sbjct: 1293 IFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDI------------LV 1340
Query: 346 GQLLKSTEKYSDFYFLACWHIYYNNIIAITIFFAWIKIFKFISFNKTMSQLSSTLSRCVK 405
+ S K ++ + ++ + IS + + + TL +K
Sbjct: 1341 SMVSDSGTKIL-------------GMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLK 1387
Query: 406 DIVGFAIMFFIIFFAYAQLGFLVF--------GSQVDDFSTFQNSIFAQFRIVLGDFNFA 457
I ++ F + LG +F G + + + A +R V +NF
Sbjct: 1388 PIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRHKYNFD 1447
Query: 458 GIQQA----------------------------NPILGP-----IYFITFIFFVFFVLLN 484
+ QA PI+ +YFI+F+ V F +LN
Sbjct: 1448 NLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLN 1507
Query: 485 MFLAIINDTYSEVK 498
MF+ ++ + + + +
Sbjct: 1508 MFVGVVVENFHKCR 1521
Score = 33.1 bits (74), Expect = 0.77
Identities = 25/132 (18%), Positives = 56/132 (42%), Gaps = 23/132 (17%)
Query: 378 FAWIKIFKFISFNKTMSQLSSTLSRCVKDIVGFAIMFFIIFFAYAQLGFLVFGSQ----- 432
F +++ K + F + + L + + ++ F ++ + F ++ LG +FG +
Sbjct: 836 FRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASER 895
Query: 433 ----VDDFSTFQNSIFAQFRIVLGDFNFAGIQQANPIL----------GPIYFITFIFFV 478
+ D F + ++A ++ F + N +L +YFI + F
Sbjct: 896 DGDTLPDRKNFDSLLWA----IVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFG 951
Query: 479 FFVLLNMFLAII 490
+VL N+ +AI+
Sbjct: 952 NYVLFNLLVAIL 963
>gi|38505286 voltage-dependent calcium channel alpha 1G subunit
isoform 10 [Homo sapiens]
Length = 2266
Score = 62.0 bits (149), Expect = 2e-09
Identities = 56/259 (21%), Positives = 103/259 (39%), Gaps = 54/259 (20%)
Query: 291 IFLFVFTTQEVKKIKEFK-SAYFKSIWNWLELLLLLLCFVAVSFNTYYNVQIFLLLGQLL 349
IF +F + V K+ F +F+ WN L+L ++LL + ++ V L +
Sbjct: 1631 IFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEI-EVNASLPINP-- 1687
Query: 350 KSTEKYSDFYFLACWHIYYNNIIAITIFFAWIKIFKFISFNKTMSQLSSTLSRCVKDIVG 409
II I ++ K + M L T+ + + +
Sbjct: 1688 --------------------TIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGN 1727
Query: 410 FAIMFFIIFFAYAQLGFLVFGSQVDD-------------FSTFQNSIFAQFRIVLGDFNF 456
++F ++FF +A LG +FG D F F + FR+ GD N+
Sbjct: 1728 LGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGD-NW 1786
Query: 457 AGIQQA------------NPILGPIYFITFIFFVFFVLLNMFLAI----INDTYSEVKAD 500
GI + N ++ PIYF++F+ FVL+N+ +A+ + ++ E K +
Sbjct: 1787 NGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEE 1846
Query: 501 YSIGRRLDFELGKMIKQSY 519
+ L+ E+ + Q +
Sbjct: 1847 AELEAELELEMKTLSPQPH 1865
Score = 33.5 bits (75), Expect = 0.59
Identities = 47/254 (18%), Positives = 90/254 (35%), Gaps = 71/254 (27%)
Query: 291 IFLFVFTTQEVKKIKEF-----KSAYFKSIWNWLELLLLLLCFVAVSFNTYYNVQIFLLL 345
IF VF + K+ + AY +S WN L+ LL+L+ + + L+
Sbjct: 1316 IFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDI------------LV 1363
Query: 346 GQLLKSTEKYSDFYFLACWHIYYNNIIAITIFFAWIKIFKFISFNKTMSQLSSTLSRCVK 405
+ S K ++ + ++ + IS + + + TL +K
Sbjct: 1364 SMVSDSGTKIL-------------GMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLK 1410
Query: 406 DIVGFAIMFFIIFFAYAQLGFLVF--------GSQVDDFSTFQNSIFAQFRIVLGDFNFA 457
I ++ F + LG +F G + + + A +R V +NF
Sbjct: 1411 PIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRHKYNFD 1470
Query: 458 GIQQA----------------------------NPILGP-----IYFITFIFFVFFVLLN 484
+ QA PI+ +YFI+F+ V F +LN
Sbjct: 1471 NLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLN 1530
Query: 485 MFLAIINDTYSEVK 498
MF+ ++ + + + +
Sbjct: 1531 MFVGVVVENFHKCR 1544
Score = 33.1 bits (74), Expect = 0.77
Identities = 25/132 (18%), Positives = 56/132 (42%), Gaps = 23/132 (17%)
Query: 378 FAWIKIFKFISFNKTMSQLSSTLSRCVKDIVGFAIMFFIIFFAYAQLGFLVFGSQ----- 432
F +++ K + F + + L + + ++ F ++ + F ++ LG +FG +
Sbjct: 836 FRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASER 895
Query: 433 ----VDDFSTFQNSIFAQFRIVLGDFNFAGIQQANPIL----------GPIYFITFIFFV 478
+ D F + ++A ++ F + N +L +YFI + F
Sbjct: 896 DGDTLPDRKNFDSLLWA----IVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFG 951
Query: 479 FFVLLNMFLAII 490
+VL N+ +AI+
Sbjct: 952 NYVLFNLLVAIL 963
>gi|38505284 voltage-dependent calcium channel alpha 1G subunit
isoform 4 [Homo sapiens]
Length = 2332
Score = 62.0 bits (149), Expect = 2e-09
Identities = 56/259 (21%), Positives = 103/259 (39%), Gaps = 54/259 (20%)
Query: 291 IFLFVFTTQEVKKIKEFK-SAYFKSIWNWLELLLLLLCFVAVSFNTYYNVQIFLLLGQLL 349
IF +F + V K+ F +F+ WN L+L ++LL + ++ V L +
Sbjct: 1649 IFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEI-EVNASLPINP-- 1705
Query: 350 KSTEKYSDFYFLACWHIYYNNIIAITIFFAWIKIFKFISFNKTMSQLSSTLSRCVKDIVG 409
II I ++ K + M L T+ + + +
Sbjct: 1706 --------------------TIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGN 1745
Query: 410 FAIMFFIIFFAYAQLGFLVFGSQVDD-------------FSTFQNSIFAQFRIVLGDFNF 456
++F ++FF +A LG +FG D F F + FR+ GD N+
Sbjct: 1746 LGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGD-NW 1804
Query: 457 AGIQQA------------NPILGPIYFITFIFFVFFVLLNMFLAI----INDTYSEVKAD 500
GI + N ++ PIYF++F+ FVL+N+ +A+ + ++ E K +
Sbjct: 1805 NGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEE 1864
Query: 501 YSIGRRLDFELGKMIKQSY 519
+ L+ E+ + Q +
Sbjct: 1865 AELEAELELEMKTLSPQPH 1883
Score = 33.5 bits (75), Expect = 0.59
Identities = 47/254 (18%), Positives = 90/254 (35%), Gaps = 71/254 (27%)
Query: 291 IFLFVFTTQEVKKIKEF-----KSAYFKSIWNWLELLLLLLCFVAVSFNTYYNVQIFLLL 345
IF VF + K+ + AY +S WN L+ LL+L+ + + L+
Sbjct: 1316 IFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDI------------LV 1363
Query: 346 GQLLKSTEKYSDFYFLACWHIYYNNIIAITIFFAWIKIFKFISFNKTMSQLSSTLSRCVK 405
+ S K ++ + ++ + IS + + + TL +K
Sbjct: 1364 SMVSDSGTKIL-------------GMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLK 1410
Query: 406 DIVGFAIMFFIIFFAYAQLGFLVF--------GSQVDDFSTFQNSIFAQFRIVLGDFNFA 457
I ++ F + LG +F G + + + A +R V +NF
Sbjct: 1411 PIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRHKYNFD 1470
Query: 458 GIQQA----------------------------NPILGP-----IYFITFIFFVFFVLLN 484
+ QA PI+ +YFI+F+ V F +LN
Sbjct: 1471 NLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLN 1530
Query: 485 MFLAIINDTYSEVK 498
MF+ ++ + + + +
Sbjct: 1531 MFVGVVVENFHKCR 1544
Score = 33.1 bits (74), Expect = 0.77
Identities = 25/132 (18%), Positives = 56/132 (42%), Gaps = 23/132 (17%)
Query: 378 FAWIKIFKFISFNKTMSQLSSTLSRCVKDIVGFAIMFFIIFFAYAQLGFLVFGSQ----- 432
F +++ K + F + + L + + ++ F ++ + F ++ LG +FG +
Sbjct: 836 FRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASER 895
Query: 433 ----VDDFSTFQNSIFAQFRIVLGDFNFAGIQQANPIL----------GPIYFITFIFFV 478
+ D F + ++A ++ F + N +L +YFI + F
Sbjct: 896 DGDTLPDRKNFDSLLWA----IVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFG 951
Query: 479 FFVLLNMFLAII 490
+VL N+ +AI+
Sbjct: 952 NYVLFNLLVAIL 963
>gi|38505282 voltage-dependent calcium channel alpha 1G subunit
isoform 8 [Homo sapiens]
Length = 2284
Score = 62.0 bits (149), Expect = 2e-09
Identities = 56/259 (21%), Positives = 103/259 (39%), Gaps = 54/259 (20%)
Query: 291 IFLFVFTTQEVKKIKEFK-SAYFKSIWNWLELLLLLLCFVAVSFNTYYNVQIFLLLGQLL 349
IF +F + V K+ F +F+ WN L+L ++LL + ++ V L +
Sbjct: 1649 IFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEI-EVNASLPINP-- 1705
Query: 350 KSTEKYSDFYFLACWHIYYNNIIAITIFFAWIKIFKFISFNKTMSQLSSTLSRCVKDIVG 409
II I ++ K + M L T+ + + +
Sbjct: 1706 --------------------TIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGN 1745
Query: 410 FAIMFFIIFFAYAQLGFLVFGSQVDD-------------FSTFQNSIFAQFRIVLGDFNF 456
++F ++FF +A LG +FG D F F + FR+ GD N+
Sbjct: 1746 LGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGD-NW 1804
Query: 457 AGIQQA------------NPILGPIYFITFIFFVFFVLLNMFLAI----INDTYSEVKAD 500
GI + N ++ PIYF++F+ FVL+N+ +A+ + ++ E K +
Sbjct: 1805 NGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEE 1864
Query: 501 YSIGRRLDFELGKMIKQSY 519
+ L+ E+ + Q +
Sbjct: 1865 AELEAELELEMKTLSPQPH 1883
Score = 33.5 bits (75), Expect = 0.59
Identities = 47/254 (18%), Positives = 90/254 (35%), Gaps = 71/254 (27%)
Query: 291 IFLFVFTTQEVKKIKEF-----KSAYFKSIWNWLELLLLLLCFVAVSFNTYYNVQIFLLL 345
IF VF + K+ + AY +S WN L+ LL+L+ + + L+
Sbjct: 1316 IFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDI------------LV 1363
Query: 346 GQLLKSTEKYSDFYFLACWHIYYNNIIAITIFFAWIKIFKFISFNKTMSQLSSTLSRCVK 405
+ S K ++ + ++ + IS + + + TL +K
Sbjct: 1364 SMVSDSGTKIL-------------GMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLK 1410
Query: 406 DIVGFAIMFFIIFFAYAQLGFLVF--------GSQVDDFSTFQNSIFAQFRIVLGDFNFA 457
I ++ F + LG +F G + + + A +R V +NF
Sbjct: 1411 PIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRHKYNFD 1470
Query: 458 GIQQA----------------------------NPILGP-----IYFITFIFFVFFVLLN 484
+ QA PI+ +YFI+F+ V F +LN
Sbjct: 1471 NLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLN 1530
Query: 485 MFLAIINDTYSEVK 498
MF+ ++ + + + +
Sbjct: 1531 MFVGVVVENFHKCR 1544
Score = 33.1 bits (74), Expect = 0.77
Identities = 25/132 (18%), Positives = 56/132 (42%), Gaps = 23/132 (17%)
Query: 378 FAWIKIFKFISFNKTMSQLSSTLSRCVKDIVGFAIMFFIIFFAYAQLGFLVFGSQ----- 432
F +++ K + F + + L + + ++ F ++ + F ++ LG +FG +
Sbjct: 836 FRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASER 895
Query: 433 ----VDDFSTFQNSIFAQFRIVLGDFNFAGIQQANPIL----------GPIYFITFIFFV 478
+ D F + ++A ++ F + N +L +YFI + F
Sbjct: 896 DGDTLPDRKNFDSLLWA----IVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFG 951
Query: 479 FFVLLNMFLAII 490
+VL N+ +AI+
Sbjct: 952 NYVLFNLLVAIL 963
>gi|38505280 voltage-dependent calcium channel alpha 1G subunit
isoform 6 [Homo sapiens]
Length = 2306
Score = 62.0 bits (149), Expect = 2e-09
Identities = 56/259 (21%), Positives = 103/259 (39%), Gaps = 54/259 (20%)
Query: 291 IFLFVFTTQEVKKIKEFK-SAYFKSIWNWLELLLLLLCFVAVSFNTYYNVQIFLLLGQLL 349
IF +F + V K+ F +F+ WN L+L ++LL + ++ V L +
Sbjct: 1626 IFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEI-EVNASLPINP-- 1682
Query: 350 KSTEKYSDFYFLACWHIYYNNIIAITIFFAWIKIFKFISFNKTMSQLSSTLSRCVKDIVG 409
II I ++ K + M L T+ + + +
Sbjct: 1683 --------------------TIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGN 1722
Query: 410 FAIMFFIIFFAYAQLGFLVFGSQVDD-------------FSTFQNSIFAQFRIVLGDFNF 456
++F ++FF +A LG +FG D F F + FR+ GD N+
Sbjct: 1723 LGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGD-NW 1781
Query: 457 AGIQQA------------NPILGPIYFITFIFFVFFVLLNMFLAI----INDTYSEVKAD 500
GI + N ++ PIYF++F+ FVL+N+ +A+ + ++ E K +
Sbjct: 1782 NGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEE 1841
Query: 501 YSIGRRLDFELGKMIKQSY 519
+ L+ E+ + Q +
Sbjct: 1842 AELEAELELEMKTLSPQPH 1860
Score = 33.5 bits (75), Expect = 0.59
Identities = 47/254 (18%), Positives = 90/254 (35%), Gaps = 71/254 (27%)
Query: 291 IFLFVFTTQEVKKIKEF-----KSAYFKSIWNWLELLLLLLCFVAVSFNTYYNVQIFLLL 345
IF VF + K+ + AY +S WN L+ LL+L+ + + L+
Sbjct: 1293 IFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDI------------LV 1340
Query: 346 GQLLKSTEKYSDFYFLACWHIYYNNIIAITIFFAWIKIFKFISFNKTMSQLSSTLSRCVK 405
+ S K ++ + ++ + IS + + + TL +K
Sbjct: 1341 SMVSDSGTKIL-------------GMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLK 1387
Query: 406 DIVGFAIMFFIIFFAYAQLGFLVF--------GSQVDDFSTFQNSIFAQFRIVLGDFNFA 457
I ++ F + LG +F G + + + A +R V +NF
Sbjct: 1388 PIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRHKYNFD 1447
Query: 458 GIQQA----------------------------NPILGP-----IYFITFIFFVFFVLLN 484
+ QA PI+ +YFI+F+ V F +LN
Sbjct: 1448 NLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLN 1507
Query: 485 MFLAIINDTYSEVK 498
MF+ ++ + + + +
Sbjct: 1508 MFVGVVVENFHKCR 1521
Score = 33.1 bits (74), Expect = 0.77
Identities = 25/132 (18%), Positives = 56/132 (42%), Gaps = 23/132 (17%)
Query: 378 FAWIKIFKFISFNKTMSQLSSTLSRCVKDIVGFAIMFFIIFFAYAQLGFLVFGSQ----- 432
F +++ K + F + + L + + ++ F ++ + F ++ LG +FG +
Sbjct: 836 FRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASER 895
Query: 433 ----VDDFSTFQNSIFAQFRIVLGDFNFAGIQQANPIL----------GPIYFITFIFFV 478
+ D F + ++A ++ F + N +L +YFI + F
Sbjct: 896 DGDTLPDRKNFDSLLWA----IVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFG 951
Query: 479 FFVLLNMFLAII 490
+VL N+ +AI+
Sbjct: 952 NYVLFNLLVAIL 963
>gi|38505278 voltage-dependent calcium channel alpha 1G subunit
isoform 11 [Homo sapiens]
Length = 2261
Score = 62.0 bits (149), Expect = 2e-09
Identities = 56/259 (21%), Positives = 103/259 (39%), Gaps = 54/259 (20%)
Query: 291 IFLFVFTTQEVKKIKEFK-SAYFKSIWNWLELLLLLLCFVAVSFNTYYNVQIFLLLGQLL 349
IF +F + V K+ F +F+ WN L+L ++LL + ++ V L +
Sbjct: 1626 IFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEI-EVNASLPINP-- 1682
Query: 350 KSTEKYSDFYFLACWHIYYNNIIAITIFFAWIKIFKFISFNKTMSQLSSTLSRCVKDIVG 409
II I ++ K + M L T+ + + +
Sbjct: 1683 --------------------TIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGN 1722
Query: 410 FAIMFFIIFFAYAQLGFLVFGSQVDD-------------FSTFQNSIFAQFRIVLGDFNF 456
++F ++FF +A LG +FG D F F + FR+ GD N+
Sbjct: 1723 LGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGD-NW 1781
Query: 457 AGIQQA------------NPILGPIYFITFIFFVFFVLLNMFLAI----INDTYSEVKAD 500
GI + N ++ PIYF++F+ FVL+N+ +A+ + ++ E K +
Sbjct: 1782 NGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEE 1841
Query: 501 YSIGRRLDFELGKMIKQSY 519
+ L+ E+ + Q +
Sbjct: 1842 AELEAELELEMKTLSPQPH 1860
Score = 33.5 bits (75), Expect = 0.59
Identities = 47/254 (18%), Positives = 90/254 (35%), Gaps = 71/254 (27%)
Query: 291 IFLFVFTTQEVKKIKEF-----KSAYFKSIWNWLELLLLLLCFVAVSFNTYYNVQIFLLL 345
IF VF + K+ + AY +S WN L+ LL+L+ + + L+
Sbjct: 1293 IFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDI------------LV 1340
Query: 346 GQLLKSTEKYSDFYFLACWHIYYNNIIAITIFFAWIKIFKFISFNKTMSQLSSTLSRCVK 405
+ S K ++ + ++ + IS + + + TL +K
Sbjct: 1341 SMVSDSGTKIL-------------GMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLK 1387
Query: 406 DIVGFAIMFFIIFFAYAQLGFLVF--------GSQVDDFSTFQNSIFAQFRIVLGDFNFA 457
I ++ F + LG +F G + + + A +R V +NF
Sbjct: 1388 PIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRHKYNFD 1447
Query: 458 GIQQA----------------------------NPILGP-----IYFITFIFFVFFVLLN 484
+ QA PI+ +YFI+F+ V F +LN
Sbjct: 1448 NLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLN 1507
Query: 485 MFLAIINDTYSEVK 498
MF+ ++ + + + +
Sbjct: 1508 MFVGVVVENFHKCR 1521
Score = 33.1 bits (74), Expect = 0.77
Identities = 25/132 (18%), Positives = 56/132 (42%), Gaps = 23/132 (17%)
Query: 378 FAWIKIFKFISFNKTMSQLSSTLSRCVKDIVGFAIMFFIIFFAYAQLGFLVFGSQ----- 432
F +++ K + F + + L + + ++ F ++ + F ++ LG +FG +
Sbjct: 836 FRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASER 895
Query: 433 ----VDDFSTFQNSIFAQFRIVLGDFNFAGIQQANPIL----------GPIYFITFIFFV 478
+ D F + ++A ++ F + N +L +YFI + F
Sbjct: 896 DGDTLPDRKNFDSLLWA----IVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFG 951
Query: 479 FFVLLNMFLAII 490
+VL N+ +AI+
Sbjct: 952 NYVLFNLLVAIL 963
>gi|38505276 voltage-dependent calcium channel alpha 1G subunit
isoform 5 [Homo sapiens]
Length = 2321
Score = 62.0 bits (149), Expect = 2e-09
Identities = 56/259 (21%), Positives = 103/259 (39%), Gaps = 54/259 (20%)
Query: 291 IFLFVFTTQEVKKIKEFK-SAYFKSIWNWLELLLLLLCFVAVSFNTYYNVQIFLLLGQLL 349
IF +F + V K+ F +F+ WN L+L ++LL + ++ V L +
Sbjct: 1638 IFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEI-EVNASLPINP-- 1694
Query: 350 KSTEKYSDFYFLACWHIYYNNIIAITIFFAWIKIFKFISFNKTMSQLSSTLSRCVKDIVG 409
II I ++ K + M L T+ + + +
Sbjct: 1695 --------------------TIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGN 1734
Query: 410 FAIMFFIIFFAYAQLGFLVFGSQVDD-------------FSTFQNSIFAQFRIVLGDFNF 456
++F ++FF +A LG +FG D F F + FR+ GD N+
Sbjct: 1735 LGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGD-NW 1793
Query: 457 AGIQQA------------NPILGPIYFITFIFFVFFVLLNMFLAI----INDTYSEVKAD 500
GI + N ++ PIYF++F+ FVL+N+ +A+ + ++ E K +
Sbjct: 1794 NGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEE 1853
Query: 501 YSIGRRLDFELGKMIKQSY 519
+ L+ E+ + Q +
Sbjct: 1854 AELEAELELEMKTLSPQPH 1872
Score = 33.5 bits (75), Expect = 0.59
Identities = 47/254 (18%), Positives = 90/254 (35%), Gaps = 71/254 (27%)
Query: 291 IFLFVFTTQEVKKIKEF-----KSAYFKSIWNWLELLLLLLCFVAVSFNTYYNVQIFLLL 345
IF VF + K+ + AY +S WN L+ LL+L+ + + L+
Sbjct: 1316 IFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDI------------LV 1363
Query: 346 GQLLKSTEKYSDFYFLACWHIYYNNIIAITIFFAWIKIFKFISFNKTMSQLSSTLSRCVK 405
+ S K ++ + ++ + IS + + + TL +K
Sbjct: 1364 SMVSDSGTKIL-------------GMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLK 1410
Query: 406 DIVGFAIMFFIIFFAYAQLGFLVF--------GSQVDDFSTFQNSIFAQFRIVLGDFNFA 457
I ++ F + LG +F G + + + A +R V +NF
Sbjct: 1411 PIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRHKYNFD 1470
Query: 458 GIQQA----------------------------NPILGP-----IYFITFIFFVFFVLLN 484
+ QA PI+ +YFI+F+ V F +LN
Sbjct: 1471 NLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLN 1530
Query: 485 MFLAIINDTYSEVK 498
MF+ ++ + + + +
Sbjct: 1531 MFVGVVVENFHKCR 1544
Score = 33.1 bits (74), Expect = 0.77
Identities = 25/132 (18%), Positives = 56/132 (42%), Gaps = 23/132 (17%)
Query: 378 FAWIKIFKFISFNKTMSQLSSTLSRCVKDIVGFAIMFFIIFFAYAQLGFLVFGSQ----- 432
F +++ K + F + + L + + ++ F ++ + F ++ LG +FG +
Sbjct: 836 FRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASER 895
Query: 433 ----VDDFSTFQNSIFAQFRIVLGDFNFAGIQQANPIL----------GPIYFITFIFFV 478
+ D F + ++A ++ F + N +L +YFI + F
Sbjct: 896 DGDTLPDRKNFDSLLWA----IVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFG 951
Query: 479 FFVLLNMFLAII 490
+VL N+ +AI+
Sbjct: 952 NYVLFNLLVAIL 963
>gi|38505274 voltage-dependent calcium channel alpha 1G subunit
isoform 7 [Homo sapiens]
Length = 2298
Score = 62.0 bits (149), Expect = 2e-09
Identities = 56/259 (21%), Positives = 103/259 (39%), Gaps = 54/259 (20%)
Query: 291 IFLFVFTTQEVKKIKEFK-SAYFKSIWNWLELLLLLLCFVAVSFNTYYNVQIFLLLGQLL 349
IF +F + V K+ F +F+ WN L+L ++LL + ++ V L +
Sbjct: 1615 IFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEI-EVNASLPINP-- 1671
Query: 350 KSTEKYSDFYFLACWHIYYNNIIAITIFFAWIKIFKFISFNKTMSQLSSTLSRCVKDIVG 409
II I ++ K + M L T+ + + +
Sbjct: 1672 --------------------TIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGN 1711
Query: 410 FAIMFFIIFFAYAQLGFLVFGSQVDD-------------FSTFQNSIFAQFRIVLGDFNF 456
++F ++FF +A LG +FG D F F + FR+ GD N+
Sbjct: 1712 LGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGD-NW 1770
Query: 457 AGIQQA------------NPILGPIYFITFIFFVFFVLLNMFLAI----INDTYSEVKAD 500
GI + N ++ PIYF++F+ FVL+N+ +A+ + ++ E K +
Sbjct: 1771 NGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEE 1830
Query: 501 YSIGRRLDFELGKMIKQSY 519
+ L+ E+ + Q +
Sbjct: 1831 AELEAELELEMKTLSPQPH 1849
Score = 33.5 bits (75), Expect = 0.59
Identities = 47/254 (18%), Positives = 90/254 (35%), Gaps = 71/254 (27%)
Query: 291 IFLFVFTTQEVKKIKEF-----KSAYFKSIWNWLELLLLLLCFVAVSFNTYYNVQIFLLL 345
IF VF + K+ + AY +S WN L+ LL+L+ + + L+
Sbjct: 1293 IFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDI------------LV 1340
Query: 346 GQLLKSTEKYSDFYFLACWHIYYNNIIAITIFFAWIKIFKFISFNKTMSQLSSTLSRCVK 405
+ S K ++ + ++ + IS + + + TL +K
Sbjct: 1341 SMVSDSGTKIL-------------GMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLK 1387
Query: 406 DIVGFAIMFFIIFFAYAQLGFLVF--------GSQVDDFSTFQNSIFAQFRIVLGDFNFA 457
I ++ F + LG +F G + + + A +R V +NF
Sbjct: 1388 PIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRHKYNFD 1447
Query: 458 GIQQA----------------------------NPILGP-----IYFITFIFFVFFVLLN 484
+ QA PI+ +YFI+F+ V F +LN
Sbjct: 1448 NLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLN 1507
Query: 485 MFLAIINDTYSEVK 498
MF+ ++ + + + +
Sbjct: 1508 MFVGVVVENFHKCR 1521
Score = 33.1 bits (74), Expect = 0.77
Identities = 25/132 (18%), Positives = 56/132 (42%), Gaps = 23/132 (17%)
Query: 378 FAWIKIFKFISFNKTMSQLSSTLSRCVKDIVGFAIMFFIIFFAYAQLGFLVFGSQ----- 432
F +++ K + F + + L + + ++ F ++ + F ++ LG +FG +
Sbjct: 836 FRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASER 895
Query: 433 ----VDDFSTFQNSIFAQFRIVLGDFNFAGIQQANPIL----------GPIYFITFIFFV 478
+ D F + ++A ++ F + N +L +YFI + F
Sbjct: 896 DGDTLPDRKNFDSLLWA----IVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFG 951
Query: 479 FFVLLNMFLAII 490
+VL N+ +AI+
Sbjct: 952 NYVLFNLLVAIL 963
>gi|38505272 voltage-dependent calcium channel alpha 1G subunit
isoform 9 [Homo sapiens]
Length = 2273
Score = 62.0 bits (149), Expect = 2e-09
Identities = 56/259 (21%), Positives = 103/259 (39%), Gaps = 54/259 (20%)
Query: 291 IFLFVFTTQEVKKIKEFK-SAYFKSIWNWLELLLLLLCFVAVSFNTYYNVQIFLLLGQLL 349
IF +F + V K+ F +F+ WN L+L ++LL + ++ V L +
Sbjct: 1638 IFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEI-EVNASLPINP-- 1694
Query: 350 KSTEKYSDFYFLACWHIYYNNIIAITIFFAWIKIFKFISFNKTMSQLSSTLSRCVKDIVG 409
II I ++ K + M L T+ + + +
Sbjct: 1695 --------------------TIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGN 1734
Query: 410 FAIMFFIIFFAYAQLGFLVFGSQVDD-------------FSTFQNSIFAQFRIVLGDFNF 456
++F ++FF +A LG +FG D F F + FR+ GD N+
Sbjct: 1735 LGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGD-NW 1793
Query: 457 AGIQQA------------NPILGPIYFITFIFFVFFVLLNMFLAI----INDTYSEVKAD 500
GI + N ++ PIYF++F+ FVL+N+ +A+ + ++ E K +
Sbjct: 1794 NGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEE 1853
Query: 501 YSIGRRLDFELGKMIKQSY 519
+ L+ E+ + Q +
Sbjct: 1854 AELEAELELEMKTLSPQPH 1872
Score = 33.5 bits (75), Expect = 0.59
Identities = 47/254 (18%), Positives = 90/254 (35%), Gaps = 71/254 (27%)
Query: 291 IFLFVFTTQEVKKIKEF-----KSAYFKSIWNWLELLLLLLCFVAVSFNTYYNVQIFLLL 345
IF VF + K+ + AY +S WN L+ LL+L+ + + L+
Sbjct: 1316 IFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDI------------LV 1363
Query: 346 GQLLKSTEKYSDFYFLACWHIYYNNIIAITIFFAWIKIFKFISFNKTMSQLSSTLSRCVK 405
+ S K ++ + ++ + IS + + + TL +K
Sbjct: 1364 SMVSDSGTKIL-------------GMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLK 1410
Query: 406 DIVGFAIMFFIIFFAYAQLGFLVF--------GSQVDDFSTFQNSIFAQFRIVLGDFNFA 457
I ++ F + LG +F G + + + A +R V +NF
Sbjct: 1411 PIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRHKYNFD 1470
Query: 458 GIQQA----------------------------NPILGP-----IYFITFIFFVFFVLLN 484
+ QA PI+ +YFI+F+ V F +LN
Sbjct: 1471 NLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLN 1530
Query: 485 MFLAIINDTYSEVK 498
MF+ ++ + + + +
Sbjct: 1531 MFVGVVVENFHKCR 1544
Score = 33.1 bits (74), Expect = 0.77
Identities = 25/132 (18%), Positives = 56/132 (42%), Gaps = 23/132 (17%)
Query: 378 FAWIKIFKFISFNKTMSQLSSTLSRCVKDIVGFAIMFFIIFFAYAQLGFLVFGSQ----- 432
F +++ K + F + + L + + ++ F ++ + F ++ LG +FG +
Sbjct: 836 FRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASER 895
Query: 433 ----VDDFSTFQNSIFAQFRIVLGDFNFAGIQQANPIL----------GPIYFITFIFFV 478
+ D F + ++A ++ F + N +L +YFI + F
Sbjct: 896 DGDTLPDRKNFDSLLWA----IVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFG 951
Query: 479 FFVLLNMFLAII 490
+VL N+ +AI+
Sbjct: 952 NYVLFNLLVAIL 963
>gi|38505270 voltage-dependent calcium channel alpha 1G subunit
isoform 2 [Homo sapiens]
Length = 2354
Score = 62.0 bits (149), Expect = 2e-09
Identities = 56/259 (21%), Positives = 103/259 (39%), Gaps = 54/259 (20%)
Query: 291 IFLFVFTTQEVKKIKEFK-SAYFKSIWNWLELLLLLLCFVAVSFNTYYNVQIFLLLGQLL 349
IF +F + V K+ F +F+ WN L+L ++LL + ++ V L +
Sbjct: 1626 IFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEI-EVNASLPINP-- 1682
Query: 350 KSTEKYSDFYFLACWHIYYNNIIAITIFFAWIKIFKFISFNKTMSQLSSTLSRCVKDIVG 409
II I ++ K + M L T+ + + +
Sbjct: 1683 --------------------TIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGN 1722
Query: 410 FAIMFFIIFFAYAQLGFLVFGSQVDD-------------FSTFQNSIFAQFRIVLGDFNF 456
++F ++FF +A LG +FG D F F + FR+ GD N+
Sbjct: 1723 LGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGD-NW 1781
Query: 457 AGIQQA------------NPILGPIYFITFIFFVFFVLLNMFLAI----INDTYSEVKAD 500
GI + N ++ PIYF++F+ FVL+N+ +A+ + ++ E K +
Sbjct: 1782 NGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEE 1841
Query: 501 YSIGRRLDFELGKMIKQSY 519
+ L+ E+ + Q +
Sbjct: 1842 AELEAELELEMKTLSPQPH 1860
Score = 33.5 bits (75), Expect = 0.59
Identities = 47/254 (18%), Positives = 90/254 (35%), Gaps = 71/254 (27%)
Query: 291 IFLFVFTTQEVKKIKEF-----KSAYFKSIWNWLELLLLLLCFVAVSFNTYYNVQIFLLL 345
IF VF + K+ + AY +S WN L+ LL+L+ + + L+
Sbjct: 1293 IFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDI------------LV 1340
Query: 346 GQLLKSTEKYSDFYFLACWHIYYNNIIAITIFFAWIKIFKFISFNKTMSQLSSTLSRCVK 405
+ S K ++ + ++ + IS + + + TL +K
Sbjct: 1341 SMVSDSGTKIL-------------GMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLK 1387
Query: 406 DIVGFAIMFFIIFFAYAQLGFLVF--------GSQVDDFSTFQNSIFAQFRIVLGDFNFA 457
I ++ F + LG +F G + + + A +R V +NF
Sbjct: 1388 PIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRHKYNFD 1447
Query: 458 GIQQA----------------------------NPILGP-----IYFITFIFFVFFVLLN 484
+ QA PI+ +YFI+F+ V F +LN
Sbjct: 1448 NLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLN 1507
Query: 485 MFLAIINDTYSEVK 498
MF+ ++ + + + +
Sbjct: 1508 MFVGVVVENFHKCR 1521
Score = 33.1 bits (74), Expect = 0.77
Identities = 25/132 (18%), Positives = 56/132 (42%), Gaps = 23/132 (17%)
Query: 378 FAWIKIFKFISFNKTMSQLSSTLSRCVKDIVGFAIMFFIIFFAYAQLGFLVFGSQ----- 432
F +++ K + F + + L + + ++ F ++ + F ++ LG +FG +
Sbjct: 836 FRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASER 895
Query: 433 ----VDDFSTFQNSIFAQFRIVLGDFNFAGIQQANPIL----------GPIYFITFIFFV 478
+ D F + ++A ++ F + N +L +YFI + F
Sbjct: 896 DGDTLPDRKNFDSLLWA----IVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFG 951
Query: 479 FFVLLNMFLAII 490
+VL N+ +AI+
Sbjct: 952 NYVLFNLLVAIL 963
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.326 0.140 0.431
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,236,075
Number of Sequences: 37866
Number of extensions: 820392
Number of successful extensions: 4055
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 107
Number of HSP's successfully gapped in prelim test: 79
Number of HSP's that attempted gapping in prelim test: 3441
Number of HSP's gapped (non-prelim): 591
length of query: 613
length of database: 18,247,518
effective HSP length: 108
effective length of query: 505
effective length of database: 14,157,990
effective search space: 7149784950
effective search space used: 7149784950
T: 11
A: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.7 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.