Guide to the Human Genome
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Search of human proteins with 239746488

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|239746488 PREDICTED: Rho GTPase-activating protein 18-like
[Homo sapiens]
         (622 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|239757488 PREDICTED: chromosome 20 open reading frame 95 [Hom...  1240   0.0  
gi|239752003 PREDICTED: chromosome 20 open reading frame 95 [Hom...  1240   0.0  
gi|239746488 PREDICTED: Rho GTPase-activating protein 18-like [H...  1240   0.0  
gi|39932589 Rho GTPase activating protein 18 [Homo sapiens]           414   e-115
gi|59710113 Rho GTPase activating protein 28 isoform a [Homo sap...   302   7e-82
gi|59710111 Rho GTPase activating protein 28 isoform b [Homo sap...   253   4e-67
gi|41281907 StAR-related lipid transfer (START) domain containin...    92   2e-18
gi|16445031 StAR-related lipid transfer (START) domain containin...    92   2e-18
gi|41281898 StAR-related lipid transfer (START) domain containin...    92   2e-18
gi|224458284 Rho GTPase activating protein 23 [Homo sapiens]           90   7e-18
gi|33188433 deleted in liver cancer 1 isoform 1 [Homo sapiens]         88   2e-17
gi|33188437 deleted in liver cancer 1 isoform 2 [Homo sapiens]         88   2e-17
gi|67906814 Rho GTPase activating protein 19 [Homo sapiens]            87   5e-17
gi|42475970 synapse defective 1, Rho GTPase, homolog 1 [Homo sap...    87   5e-17
gi|7382480 Rho GTPase activating protein 6 isoform 4 [Homo sapiens]    87   6e-17
gi|95091988 Rho GTPase activating protein 6 isoform 3 [Homo sapi...    87   6e-17
gi|95091875 Rho GTPase activating protein 6 isoform 1 [Homo sapi...    87   6e-17
gi|122939147 Rho GTPase activating protein 9 isoform 1 [Homo sap...    86   8e-17
gi|122939149 Rho GTPase activating protein 9 isoform 3 [Homo sap...    86   8e-17
gi|82546845 breakpoint cluster region isoform 2 [Homo sapiens]         84   4e-16
gi|82546843 breakpoint cluster region isoform 1 [Homo sapiens]         84   4e-16
gi|226693398 Rho GTPase activating protein 27 isoform b [Homo sa...    84   5e-16
gi|40548322 Rho GTPase activating protein 27 isoform a [Homo sap...    84   5e-16
gi|203097003 Rho GTPase activating protein 21 [Homo sapiens]           83   9e-16
gi|229094128 active breakpoint cluster region-related  protein i...    82   1e-15
gi|38679957 active breakpoint cluster region-related  protein is...    82   1e-15
gi|38679954 active breakpoint cluster region-related  protein is...    82   1e-15
gi|21264337 ArfGAP with RhoGAP domain, ankyrin repeat and PH dom...    82   2e-15
gi|5803145 ralA binding protein 1 [Homo sapiens]                       81   3e-15
gi|188497642 ARHGAP15 [Homo sapiens]                                   80   4e-15

>gi|239757488 PREDICTED: chromosome 20 open reading frame 95 [Homo
           sapiens]
          Length = 622

 Score = 1240 bits (3208), Expect = 0.0
 Identities = 622/622 (100%), Positives = 622/622 (100%)

Query: 1   MDQLPQKNLLRLHPAGSAGCSTGVESSSMDGFWMEVEQIQQRDELREEDSGGNEGQLPEE 60
           MDQLPQKNLLRLHPAGSAGCSTGVESSSMDGFWMEVEQIQQRDELREEDSGGNEGQLPEE
Sbjct: 1   MDQLPQKNLLRLHPAGSAGCSTGVESSSMDGFWMEVEQIQQRDELREEDSGGNEGQLPEE 60

Query: 61  GEAESQWLQDTGLSGLLGGLGLDGDHQELLSTLTQTQVAAVCRRLDIYARSVRRQHKTPV 120
           GEAESQWLQDTGLSGLLGGLGLDGDHQELLSTLTQTQVAAVCRRLDIYARSVRRQHKTPV
Sbjct: 61  GEAESQWLQDTGLSGLLGGLGLDGDHQELLSTLTQTQVAAVCRRLDIYARSVRRQHKTPV 120

Query: 121 RDVRDVFGVFNSGKMSSENGDSGMKGAQLSSGASKFPPAAEPGGLQEQAGREEAFNMDSA 180
           RDVRDVFGVFNSGKMSSENGDSGMKGAQLSSGASKFPPAAEPGGLQEQAGREEAFNMDSA
Sbjct: 121 RDVRDVFGVFNSGKMSSENGDSGMKGAQLSSGASKFPPAAEPGGLQEQAGREEAFNMDSA 180

Query: 181 YSEQAAVLLQRSRPSRGGTSAWGKCSLPKFTVPKGRLGVTRIGDLSLQDMRKVPSLALIE 240
           YSEQAAVLLQRSRPSRGGTSAWGKCSLPKFTVPKGRLGVTRIGDLSLQDMRKVPSLALIE
Sbjct: 181 YSEQAAVLLQRSRPSRGGTSAWGKCSLPKFTVPKGRLGVTRIGDLSLQDMRKVPSLALIE 240

Query: 241 LTALCDILGLDLKRSKAGKWKAAETRLFGVPLDSLLEADHKVLPSTQVPLVLQALLSCLE 300
           LTALCDILGLDLKRSKAGKWKAAETRLFGVPLDSLLEADHKVLPSTQVPLVLQALLSCLE
Sbjct: 241 LTALCDILGLDLKRSKAGKWKAAETRLFGVPLDSLLEADHKVLPSTQVPLVLQALLSCLE 300

Query: 301 KRGLDMEGILRVPGSQARVKGLEQKLERDFYAGLFSWDEVHHNDASDLLKRFIRKLPTPL 360
           KRGLDMEGILRVPGSQARVKGLEQKLERDFYAGLFSWDEVHHNDASDLLKRFIRKLPTPL
Sbjct: 301 KRGLDMEGILRVPGSQARVKGLEQKLERDFYAGLFSWDEVHHNDASDLLKRFIRKLPTPL 360

Query: 361 LTAEYLPAFAVVPNIPNLKQRLQVLHLLILILPEPNRNALKALLEFLRKVVAREQHNKMT 420
           LTAEYLPAFAVVPNIPNLKQRLQVLHLLILILPEPNRNALKALLEFLRKVVAREQHNKMT
Sbjct: 361 LTAEYLPAFAVVPNIPNLKQRLQVLHLLILILPEPNRNALKALLEFLRKVVAREQHNKMT 420

Query: 421 LRNVSTVMAPNLFLHQGRPPKLPKGKEKQLAEGAAEVVQIMVHYQDLLWTVASFLVAQVR 480
           LRNVSTVMAPNLFLHQGRPPKLPKGKEKQLAEGAAEVVQIMVHYQDLLWTVASFLVAQVR
Sbjct: 421 LRNVSTVMAPNLFLHQGRPPKLPKGKEKQLAEGAAEVVQIMVHYQDLLWTVASFLVAQVR 480

Query: 481 KLNDSSSRRPQLCDAGLKTWLRRMHADRDKAGDGLEATPKVAKIQVVWPIKDPLKVPLTP 540
           KLNDSSSRRPQLCDAGLKTWLRRMHADRDKAGDGLEATPKVAKIQVVWPIKDPLKVPLTP
Sbjct: 481 KLNDSSSRRPQLCDAGLKTWLRRMHADRDKAGDGLEATPKVAKIQVVWPIKDPLKVPLTP 540

Query: 541 STKVAHVLRQFTEHLSPGSKGQEDSEDMDSLLLHHRSMESANILLYEVGGNINEHRLDPD 600
           STKVAHVLRQFTEHLSPGSKGQEDSEDMDSLLLHHRSMESANILLYEVGGNINEHRLDPD
Sbjct: 541 STKVAHVLRQFTEHLSPGSKGQEDSEDMDSLLLHHRSMESANILLYEVGGNINEHRLDPD 600

Query: 601 AYLLDLYRANPHGEWVLKQNPT 622
           AYLLDLYRANPHGEWVLKQNPT
Sbjct: 601 AYLLDLYRANPHGEWVLKQNPT 622


>gi|239752003 PREDICTED: chromosome 20 open reading frame 95 [Homo
           sapiens]
          Length = 622

 Score = 1240 bits (3208), Expect = 0.0
 Identities = 622/622 (100%), Positives = 622/622 (100%)

Query: 1   MDQLPQKNLLRLHPAGSAGCSTGVESSSMDGFWMEVEQIQQRDELREEDSGGNEGQLPEE 60
           MDQLPQKNLLRLHPAGSAGCSTGVESSSMDGFWMEVEQIQQRDELREEDSGGNEGQLPEE
Sbjct: 1   MDQLPQKNLLRLHPAGSAGCSTGVESSSMDGFWMEVEQIQQRDELREEDSGGNEGQLPEE 60

Query: 61  GEAESQWLQDTGLSGLLGGLGLDGDHQELLSTLTQTQVAAVCRRLDIYARSVRRQHKTPV 120
           GEAESQWLQDTGLSGLLGGLGLDGDHQELLSTLTQTQVAAVCRRLDIYARSVRRQHKTPV
Sbjct: 61  GEAESQWLQDTGLSGLLGGLGLDGDHQELLSTLTQTQVAAVCRRLDIYARSVRRQHKTPV 120

Query: 121 RDVRDVFGVFNSGKMSSENGDSGMKGAQLSSGASKFPPAAEPGGLQEQAGREEAFNMDSA 180
           RDVRDVFGVFNSGKMSSENGDSGMKGAQLSSGASKFPPAAEPGGLQEQAGREEAFNMDSA
Sbjct: 121 RDVRDVFGVFNSGKMSSENGDSGMKGAQLSSGASKFPPAAEPGGLQEQAGREEAFNMDSA 180

Query: 181 YSEQAAVLLQRSRPSRGGTSAWGKCSLPKFTVPKGRLGVTRIGDLSLQDMRKVPSLALIE 240
           YSEQAAVLLQRSRPSRGGTSAWGKCSLPKFTVPKGRLGVTRIGDLSLQDMRKVPSLALIE
Sbjct: 181 YSEQAAVLLQRSRPSRGGTSAWGKCSLPKFTVPKGRLGVTRIGDLSLQDMRKVPSLALIE 240

Query: 241 LTALCDILGLDLKRSKAGKWKAAETRLFGVPLDSLLEADHKVLPSTQVPLVLQALLSCLE 300
           LTALCDILGLDLKRSKAGKWKAAETRLFGVPLDSLLEADHKVLPSTQVPLVLQALLSCLE
Sbjct: 241 LTALCDILGLDLKRSKAGKWKAAETRLFGVPLDSLLEADHKVLPSTQVPLVLQALLSCLE 300

Query: 301 KRGLDMEGILRVPGSQARVKGLEQKLERDFYAGLFSWDEVHHNDASDLLKRFIRKLPTPL 360
           KRGLDMEGILRVPGSQARVKGLEQKLERDFYAGLFSWDEVHHNDASDLLKRFIRKLPTPL
Sbjct: 301 KRGLDMEGILRVPGSQARVKGLEQKLERDFYAGLFSWDEVHHNDASDLLKRFIRKLPTPL 360

Query: 361 LTAEYLPAFAVVPNIPNLKQRLQVLHLLILILPEPNRNALKALLEFLRKVVAREQHNKMT 420
           LTAEYLPAFAVVPNIPNLKQRLQVLHLLILILPEPNRNALKALLEFLRKVVAREQHNKMT
Sbjct: 361 LTAEYLPAFAVVPNIPNLKQRLQVLHLLILILPEPNRNALKALLEFLRKVVAREQHNKMT 420

Query: 421 LRNVSTVMAPNLFLHQGRPPKLPKGKEKQLAEGAAEVVQIMVHYQDLLWTVASFLVAQVR 480
           LRNVSTVMAPNLFLHQGRPPKLPKGKEKQLAEGAAEVVQIMVHYQDLLWTVASFLVAQVR
Sbjct: 421 LRNVSTVMAPNLFLHQGRPPKLPKGKEKQLAEGAAEVVQIMVHYQDLLWTVASFLVAQVR 480

Query: 481 KLNDSSSRRPQLCDAGLKTWLRRMHADRDKAGDGLEATPKVAKIQVVWPIKDPLKVPLTP 540
           KLNDSSSRRPQLCDAGLKTWLRRMHADRDKAGDGLEATPKVAKIQVVWPIKDPLKVPLTP
Sbjct: 481 KLNDSSSRRPQLCDAGLKTWLRRMHADRDKAGDGLEATPKVAKIQVVWPIKDPLKVPLTP 540

Query: 541 STKVAHVLRQFTEHLSPGSKGQEDSEDMDSLLLHHRSMESANILLYEVGGNINEHRLDPD 600
           STKVAHVLRQFTEHLSPGSKGQEDSEDMDSLLLHHRSMESANILLYEVGGNINEHRLDPD
Sbjct: 541 STKVAHVLRQFTEHLSPGSKGQEDSEDMDSLLLHHRSMESANILLYEVGGNINEHRLDPD 600

Query: 601 AYLLDLYRANPHGEWVLKQNPT 622
           AYLLDLYRANPHGEWVLKQNPT
Sbjct: 601 AYLLDLYRANPHGEWVLKQNPT 622


>gi|239746488 PREDICTED: Rho GTPase-activating protein 18-like [Homo
           sapiens]
          Length = 622

 Score = 1240 bits (3208), Expect = 0.0
 Identities = 622/622 (100%), Positives = 622/622 (100%)

Query: 1   MDQLPQKNLLRLHPAGSAGCSTGVESSSMDGFWMEVEQIQQRDELREEDSGGNEGQLPEE 60
           MDQLPQKNLLRLHPAGSAGCSTGVESSSMDGFWMEVEQIQQRDELREEDSGGNEGQLPEE
Sbjct: 1   MDQLPQKNLLRLHPAGSAGCSTGVESSSMDGFWMEVEQIQQRDELREEDSGGNEGQLPEE 60

Query: 61  GEAESQWLQDTGLSGLLGGLGLDGDHQELLSTLTQTQVAAVCRRLDIYARSVRRQHKTPV 120
           GEAESQWLQDTGLSGLLGGLGLDGDHQELLSTLTQTQVAAVCRRLDIYARSVRRQHKTPV
Sbjct: 61  GEAESQWLQDTGLSGLLGGLGLDGDHQELLSTLTQTQVAAVCRRLDIYARSVRRQHKTPV 120

Query: 121 RDVRDVFGVFNSGKMSSENGDSGMKGAQLSSGASKFPPAAEPGGLQEQAGREEAFNMDSA 180
           RDVRDVFGVFNSGKMSSENGDSGMKGAQLSSGASKFPPAAEPGGLQEQAGREEAFNMDSA
Sbjct: 121 RDVRDVFGVFNSGKMSSENGDSGMKGAQLSSGASKFPPAAEPGGLQEQAGREEAFNMDSA 180

Query: 181 YSEQAAVLLQRSRPSRGGTSAWGKCSLPKFTVPKGRLGVTRIGDLSLQDMRKVPSLALIE 240
           YSEQAAVLLQRSRPSRGGTSAWGKCSLPKFTVPKGRLGVTRIGDLSLQDMRKVPSLALIE
Sbjct: 181 YSEQAAVLLQRSRPSRGGTSAWGKCSLPKFTVPKGRLGVTRIGDLSLQDMRKVPSLALIE 240

Query: 241 LTALCDILGLDLKRSKAGKWKAAETRLFGVPLDSLLEADHKVLPSTQVPLVLQALLSCLE 300
           LTALCDILGLDLKRSKAGKWKAAETRLFGVPLDSLLEADHKVLPSTQVPLVLQALLSCLE
Sbjct: 241 LTALCDILGLDLKRSKAGKWKAAETRLFGVPLDSLLEADHKVLPSTQVPLVLQALLSCLE 300

Query: 301 KRGLDMEGILRVPGSQARVKGLEQKLERDFYAGLFSWDEVHHNDASDLLKRFIRKLPTPL 360
           KRGLDMEGILRVPGSQARVKGLEQKLERDFYAGLFSWDEVHHNDASDLLKRFIRKLPTPL
Sbjct: 301 KRGLDMEGILRVPGSQARVKGLEQKLERDFYAGLFSWDEVHHNDASDLLKRFIRKLPTPL 360

Query: 361 LTAEYLPAFAVVPNIPNLKQRLQVLHLLILILPEPNRNALKALLEFLRKVVAREQHNKMT 420
           LTAEYLPAFAVVPNIPNLKQRLQVLHLLILILPEPNRNALKALLEFLRKVVAREQHNKMT
Sbjct: 361 LTAEYLPAFAVVPNIPNLKQRLQVLHLLILILPEPNRNALKALLEFLRKVVAREQHNKMT 420

Query: 421 LRNVSTVMAPNLFLHQGRPPKLPKGKEKQLAEGAAEVVQIMVHYQDLLWTVASFLVAQVR 480
           LRNVSTVMAPNLFLHQGRPPKLPKGKEKQLAEGAAEVVQIMVHYQDLLWTVASFLVAQVR
Sbjct: 421 LRNVSTVMAPNLFLHQGRPPKLPKGKEKQLAEGAAEVVQIMVHYQDLLWTVASFLVAQVR 480

Query: 481 KLNDSSSRRPQLCDAGLKTWLRRMHADRDKAGDGLEATPKVAKIQVVWPIKDPLKVPLTP 540
           KLNDSSSRRPQLCDAGLKTWLRRMHADRDKAGDGLEATPKVAKIQVVWPIKDPLKVPLTP
Sbjct: 481 KLNDSSSRRPQLCDAGLKTWLRRMHADRDKAGDGLEATPKVAKIQVVWPIKDPLKVPLTP 540

Query: 541 STKVAHVLRQFTEHLSPGSKGQEDSEDMDSLLLHHRSMESANILLYEVGGNINEHRLDPD 600
           STKVAHVLRQFTEHLSPGSKGQEDSEDMDSLLLHHRSMESANILLYEVGGNINEHRLDPD
Sbjct: 541 STKVAHVLRQFTEHLSPGSKGQEDSEDMDSLLLHHRSMESANILLYEVGGNINEHRLDPD 600

Query: 601 AYLLDLYRANPHGEWVLKQNPT 622
           AYLLDLYRANPHGEWVLKQNPT
Sbjct: 601 AYLLDLYRANPHGEWVLKQNPT 622


>gi|39932589 Rho GTPase activating protein 18 [Homo sapiens]
          Length = 663

 Score =  414 bits (1065), Expect = e-115
 Identities = 239/618 (38%), Positives = 365/618 (59%), Gaps = 45/618 (7%)

Query: 24  VESSSMDGFWMEVEQIQQRDELREEDSGGNEGQLPEEGEAESQWLQDTGLSGLLGGLGLD 83
           ++  SM+ +W+E+E I++  E  +ED      + P+EGE E +WL++ GLS L G     
Sbjct: 70  LDELSMEDYWIELENIKKSSENSQEDQEVVVVKEPDEGELEEEWLKEAGLSNLFGESA-- 127

Query: 84  GDHQE---LLSTLTQTQVAAVCRRLDIYARSVRRQHKT-PVRDVRDVFGVFNSGKMSSEN 139
           GD QE    LSTLT+TQ AAV +R++  ++++R+++K   + DVRD+F      + S E 
Sbjct: 128 GDPQESIVFLSTLTRTQAAAVQKRVETVSQTLRKKNKQYQIPDVRDIFA---QQRESKET 184

Query: 140 GDSGMKGAQLSSGASKFPPAAEPGGL----------QEQAGREEAFNMDSAYSEQAAVLL 189
              G +   L +  +K+    +              +E    E   N++ +++EQA    
Sbjct: 185 APGGTESQSLRTNENKYQGRDDEASNLVGEEKLIPPEETPAPETDINLEVSFAEQALNQK 244

Query: 190 QRSRPSRGGTSAWGKCSLPKFTVPKGRLGVTRIGDLSLQDMRKVPSLALIELTALCDILG 249
           + S+  +   S     +LP F +PK + G TRIGDL+ QDM+KV  LALIELTAL D+LG
Sbjct: 245 ESSK-EKIQKSKGDDATLPSFRLPKDKTGTTRIGDLAPQDMKKVCHLALIELTALYDVLG 303

Query: 250 LDLKRSKAGKWKAAETRLFGVPLDSLLEADHKVLPSTQVPLVLQALLSCLEKRGLDMEGI 309
           ++LK+ KA K K  ++ LF VPL +LLE D + +P  ++PL+ Q L+S +E+RGL+ EG+
Sbjct: 304 IELKQQKAVKIKTKDSGLFCVPLTALLEQDQRKVPGMRIPLIFQKLISRIEERGLETEGL 363

Query: 310 LRVPGSQARVKGLEQKLERDFYAGLFSWDEVHHNDASDLLKRFIRKLPTPLLTAEYLPAF 369
           LR+PG+  R+K L Q+LE  FY G F+W+ V  +DA+ LLK FIR+LP PLL+ EYL AF
Sbjct: 364 LRIPGAAIRIKNLCQELEAKFYEGTFNWESVKQHDAASLLKLFIRELPQPLLSVEYLKAF 423

Query: 370 AVVPNIPNLKQRLQVLHLLILILPEPNRNALKALLEFLRKVVAREQHNKMTLRNVSTVMA 429
             V N+P  KQ+LQ L+LL+++LP+ NR+ LKALLEFL++V+  ++ NKMT+ NV+ VMA
Sbjct: 424 QAVQNLPTKKQQLQALNLLVILLPDANRDTLKALLEFLQRVIDNKEKNKMTVMNVAMVMA 483

Query: 430 PNLFLHQGRPPKLPKGKEKQLAEGAAEVVQIMVHYQDLLWTVASFLVAQVRKLNDSSSRR 489
           PNLF+      K  + +E  +A G A  + +++ YQ LLWT+  F+V QVRK N  + ++
Sbjct: 484 PNLFMCHALGLKSSEQREFVMAAGTANTMHLLIKYQKLLWTIPKFIVNQVRKQNTENHKK 543

Query: 490 PQLCDAGLKTWLRRMHADR------DKAGDGLEATPKVAKIQVVWPIKDPLKVPLTPSTK 543
            +     +K  L++M  DR      DK+ +  +    V ++Q     K  + + LT   K
Sbjct: 544 DK---RAMKKLLKKMAYDREKYEKQDKSTNDADVPQGVIRVQAPHLSKVSMAIQLTEELK 600

Query: 544 VAHVLRQFTEHLSPGSKGQEDSEDMDSLLLHHRSMESANILLYEVGGNINEHRLDPDAYL 603
            + VL +F    S  +                ++++   + LYE+GGNI E  LD D Y+
Sbjct: 601 ASDVLARFLSQESGVA----------------QTLKKGEVFLYEIGGNIGERCLDDDTYM 644

Query: 604 LDLYRANPHGEWVLKQNP 621
            DLY+ NP+ EWV+K  P
Sbjct: 645 KDLYQLNPNAEWVIKSKP 662


>gi|59710113 Rho GTPase activating protein 28 isoform a [Homo
           sapiens]
          Length = 570

 Score =  302 bits (773), Expect = 7e-82
 Identities = 181/462 (39%), Positives = 265/462 (57%), Gaps = 37/462 (8%)

Query: 173 EAFNMDSAYSEQAAVLLQRSRPSRGGTSAWGKCSLPKFTVPKGRLGVTRIGDLSLQDMRK 232
           E  + + +YSE     L+R++  +          L KF V K R G+T  GDLS +DM+K
Sbjct: 125 EELSFEVSYSEMVTEALKRNKLKKSEIKKEDYV-LTKFNVQKTRFGLTEAGDLSAEDMKK 183

Query: 233 VPSLALIELTALCDILGLDLKRSKAGKWKAAETRLFGVPLDSLLEADHKVLPSTQVPLVL 292
           +  L+LIELTA  D  G+ LKR+K  K K  +  +FGVPL  LL+ D K  P  +VPLVL
Sbjct: 184 IRHLSLIELTAFFDAFGIQLKRNKTEKVKGRDNGIFGVPLTVLLDGDRKKDPGVKVPLVL 243

Query: 293 QALLSCLEKRGLDMEGILRVPGSQARVKGLEQKLERDFYAGLFSWDEVHHNDASDLLKRF 352
           Q     +E+ GL+ EGI R+ G  A+VK   ++L+  F A  F WD++ H +A+ +LK F
Sbjct: 244 QKFFEKVEESGLESEGIFRLSGCTAKVKQYREELDAKFNADKFKWDKMCHREAAVMLKAF 303

Query: 353 IRKLPTPLLTAEYLPAF-AVVPNIPNLKQRLQVLHLLILILPEPNRNALKALLEFLRKVV 411
            R+LPT L   EY+PAF +++   P++K + Q LHL+++ LP+ NR+A +AL+ F  KV+
Sbjct: 304 FRELPTSLFPVEYIPAFISLMERGPHVKVQFQALHLMVMALPDANRDAAQALMTFFNKVI 363

Query: 412 AREQHNKMTLRNVSTVMAPNLFLHQGRPPKLPKGKEKQLAEGAAEVVQIMVHYQDLLWTV 471
           A E  N+M+L N+STVMAPNLF  +    K    +E  LA  AA ++++M+ YQ +LW V
Sbjct: 364 ANESKNRMSLWNISTVMAPNLFFSRS---KHSDYEELLLANTAAHIIRLMLKYQKILWKV 420

Query: 472 ASFLVAQVRKLNDSSS-RRPQLCDAGLKTWLRRMHADRD----KAGDGLEATPKVAK--- 523
            SFL+ QVR++N+++   + QL    ++  LRR   +R+    K    L+ +P   +   
Sbjct: 421 PSFLITQVRRMNEATMLLKKQL--PSVRKLLRRKTLERETASPKTSKVLQKSPSARRMSD 478

Query: 524 -----IQVVWPI--KDPLKVPLTPSTKVAHVLRQFTEHLSPGSKGQEDSEDMDSLLLHHR 576
                I+V  P+  K  + + L   TK   +L +F    S GS                 
Sbjct: 479 VPEGVIRVHAPLLSKVSMAIQLNNQTKAKDILAKFQYENSHGSS---------------E 523

Query: 577 SMESANILLYEVGGNINEHRLDPDAYLLDLYRANPHGEWVLK 618
            ++  N  LYE+GGNI EH LDPDAY+LD+YR NP  EWV+K
Sbjct: 524 CIKIQNQRLYEIGGNIGEHCLDPDAYILDVYRINPQAEWVIK 565


>gi|59710111 Rho GTPase activating protein 28 isoform b [Homo
           sapiens]
          Length = 563

 Score =  253 bits (646), Expect = 4e-67
 Identities = 144/354 (40%), Positives = 216/354 (61%), Gaps = 14/354 (3%)

Query: 173 EAFNMDSAYSEQAAVLLQRSRPSRGGTSAWGKCSLPKFTVPKGRLGVTRIGDLSLQDMRK 232
           E  + + +YSE     L+R++  +          L KF V K R G+T  GDLS +DM+K
Sbjct: 125 EELSFEVSYSEMVTEALKRNKLKKSEIKKEDYV-LTKFNVQKTRFGLTEAGDLSAEDMKK 183

Query: 233 VPSLALIELTALCDILGLDLKRSKAGKWKAAETRLFGVPLDSLLEADHKVLPSTQVPLVL 292
           +  L+LIELTA  D  G+ LKR+K  K K  +  +FGVPL  LL+ D K  P  +VPLVL
Sbjct: 184 IRHLSLIELTAFFDAFGIQLKRNKTEKVKGRDNGIFGVPLTVLLDGDRKKDPGVKVPLVL 243

Query: 293 QALLSCLEKRGLDMEGILRVPGSQARVKGLEQKLERDFYAGLFSWDEVHHNDASDLLKRF 352
           Q     +E+ GL+ EGI R+ G  A+VK   ++L+  F A  F WD++ H +A+ +LK F
Sbjct: 244 QKFFEKVEESGLESEGIFRLSGCTAKVKQYREELDAKFNADKFKWDKMCHREAAVMLKAF 303

Query: 353 IRKLPTPLLTAEYLPAF-AVVPNIPNLKQRLQVLHLLILILPEPNRNALKALLEFLRKVV 411
            R+LPT L   EY+PAF +++   P++K + Q LHL+++ LP+ NR+A +AL+ F  KV+
Sbjct: 304 FRELPTSLFPVEYIPAFISLMERGPHVKVQFQALHLMVMALPDANRDAAQALMTFFNKVI 363

Query: 412 AREQHNKMTLRNVSTVMAPNLFLHQGRPPKLPKGKEKQLAEGAAEVVQIMVHYQDLLWTV 471
           A E  N+M+L N+STVMAPNLF  +    K    +E  LA  AA ++++M+ YQ +LW V
Sbjct: 364 ANESKNRMSLWNISTVMAPNLFFSRS---KHSDYEELLLANTAAHIIRLMLKYQKILWKV 420

Query: 472 ASFLVAQVRKLNDSSS-RRPQLCDAGLKTWLRRMHADRDKAGDGLEATPKVAKI 524
            SFL+ QVR++N+++   + QL    ++  LRR   +R+       A+PK +K+
Sbjct: 421 PSFLITQVRRMNEATMLLKKQL--PSVRKLLRRKTLERE------TASPKTSKV 466


>gi|41281907 StAR-related lipid transfer (START) domain containing
           13 isoform beta [Homo sapiens]
          Length = 1105

 Score = 91.7 bits (226), Expect = 2e-18
 Identities = 74/242 (30%), Positives = 119/242 (49%), Gaps = 22/242 (9%)

Query: 252 LKRSKAGKWKAAETRLFGVPLDSLLEADHKVLPSTQVPLVLQALLSCLEKRGLDMEGILR 311
           +KR K   +K  +  +FGVPL   ++   + LP +     +Q  L  L    LD  G+ R
Sbjct: 639 MKRMKVPDYK--DKAVFGVPLIVHVQRTGQPLPQS-----IQQALRYLRSNCLDQVGLFR 691

Query: 312 VPGSQARVKGLEQKLERDFYAGLFSWDEVHHNDASDLLKRFIRKLPTPLLTAEYLPAFAV 371
             G ++R+  L Q  E   +    ++++    D +D++K+F R LP PL T +    F  
Sbjct: 692 KSGVKSRIHALRQMNEN--FPENVNYEDQSAYDVADMVKQFFRDLPEPLFTNKLSETFLH 749

Query: 372 VPNIPNLKQRLQVLHLLILILPEPNRNALKALLEFLRKVVAREQHNKMTLRNVSTVMAPN 431
           +    + +QRLQ +   IL+L + NR  L+ LL FL  VV   + N+MT  N++  +AP+
Sbjct: 750 IYQYVSKEQRLQAVQAAILLLADENREVLQTLLCFLNDVVNLVEENQMTPMNLAVCLAPS 809

Query: 432 LF-LHQGRPPKLPKGKEKQLAEG------------AAEVVQIMVHYQDLLWTVASFLVAQ 478
           LF L+  +    P+  +K+ A G            AA+ +  M+   D L+ V   LVAQ
Sbjct: 810 LFHLNLLKKESSPRVIQKKYATGKPDQKDLNENLAAAQGLAHMIMECDRLFEVPHELVAQ 869

Query: 479 VR 480
            R
Sbjct: 870 SR 871


>gi|16445031 StAR-related lipid transfer (START) domain containing
           13 isoform gamma [Homo sapiens]
          Length = 995

 Score = 91.7 bits (226), Expect = 2e-18
 Identities = 74/242 (30%), Positives = 119/242 (49%), Gaps = 22/242 (9%)

Query: 252 LKRSKAGKWKAAETRLFGVPLDSLLEADHKVLPSTQVPLVLQALLSCLEKRGLDMEGILR 311
           +KR K   +K  +  +FGVPL   ++   + LP +     +Q  L  L    LD  G+ R
Sbjct: 529 MKRMKVPDYK--DKAVFGVPLIVHVQRTGQPLPQS-----IQQALRYLRSNCLDQVGLFR 581

Query: 312 VPGSQARVKGLEQKLERDFYAGLFSWDEVHHNDASDLLKRFIRKLPTPLLTAEYLPAFAV 371
             G ++R+  L Q  E   +    ++++    D +D++K+F R LP PL T +    F  
Sbjct: 582 KSGVKSRIHALRQMNEN--FPENVNYEDQSAYDVADMVKQFFRDLPEPLFTNKLSETFLH 639

Query: 372 VPNIPNLKQRLQVLHLLILILPEPNRNALKALLEFLRKVVAREQHNKMTLRNVSTVMAPN 431
           +    + +QRLQ +   IL+L + NR  L+ LL FL  VV   + N+MT  N++  +AP+
Sbjct: 640 IYQYVSKEQRLQAVQAAILLLADENREVLQTLLCFLNDVVNLVEENQMTPMNLAVCLAPS 699

Query: 432 LF-LHQGRPPKLPKGKEKQLAEG------------AAEVVQIMVHYQDLLWTVASFLVAQ 478
           LF L+  +    P+  +K+ A G            AA+ +  M+   D L+ V   LVAQ
Sbjct: 700 LFHLNLLKKESSPRVIQKKYATGKPDQKDLNENLAAAQGLAHMIMECDRLFEVPHELVAQ 759

Query: 479 VR 480
            R
Sbjct: 760 SR 761


>gi|41281898 StAR-related lipid transfer (START) domain containing
           13 isoform alpha [Homo sapiens]
          Length = 1113

 Score = 91.7 bits (226), Expect = 2e-18
 Identities = 74/242 (30%), Positives = 119/242 (49%), Gaps = 22/242 (9%)

Query: 252 LKRSKAGKWKAAETRLFGVPLDSLLEADHKVLPSTQVPLVLQALLSCLEKRGLDMEGILR 311
           +KR K   +K  +  +FGVPL   ++   + LP +     +Q  L  L    LD  G+ R
Sbjct: 647 MKRMKVPDYK--DKAVFGVPLIVHVQRTGQPLPQS-----IQQALRYLRSNCLDQVGLFR 699

Query: 312 VPGSQARVKGLEQKLERDFYAGLFSWDEVHHNDASDLLKRFIRKLPTPLLTAEYLPAFAV 371
             G ++R+  L Q  E   +    ++++    D +D++K+F R LP PL T +    F  
Sbjct: 700 KSGVKSRIHALRQMNEN--FPENVNYEDQSAYDVADMVKQFFRDLPEPLFTNKLSETFLH 757

Query: 372 VPNIPNLKQRLQVLHLLILILPEPNRNALKALLEFLRKVVAREQHNKMTLRNVSTVMAPN 431
           +    + +QRLQ +   IL+L + NR  L+ LL FL  VV   + N+MT  N++  +AP+
Sbjct: 758 IYQYVSKEQRLQAVQAAILLLADENREVLQTLLCFLNDVVNLVEENQMTPMNLAVCLAPS 817

Query: 432 LF-LHQGRPPKLPKGKEKQLAEG------------AAEVVQIMVHYQDLLWTVASFLVAQ 478
           LF L+  +    P+  +K+ A G            AA+ +  M+   D L+ V   LVAQ
Sbjct: 818 LFHLNLLKKESSPRVIQKKYATGKPDQKDLNENLAAAQGLAHMIMECDRLFEVPHELVAQ 877

Query: 479 VR 480
            R
Sbjct: 878 SR 879


>gi|224458284 Rho GTPase activating protein 23 [Homo sapiens]
          Length = 1397

 Score = 89.7 bits (221), Expect = 7e-18
 Identities = 63/177 (35%), Positives = 88/177 (49%), Gaps = 9/177 (5%)

Query: 259 KWKAAETRLFGVPLDSLLEADHKVLPSTQVPLVLQALLSCLEKRGLDMEGILRVPGSQAR 318
           K K A  R FGV L+    A      + +VPL++ A    +E RGL+  GI RVPG+ A 
Sbjct: 800 KNKKAAPRAFGVRLEECQPATE----NQRVPLIVAACCRIVEARGLESTGIYRVPGNNAV 855

Query: 319 VKGLEQKLER---DFYAGLFSWDEVHHNDASDLLKRFIRKLPTPLLTAEYLPAFAVVPNI 375
           V  L+++L R   D       W ++  N  S LLK F RKLP PL T +    F     I
Sbjct: 856 VSSLQEQLNRGPGDINLQDERWQDL--NVISSLLKSFFRKLPEPLFTDDKYNDFIEANRI 913

Query: 376 PNLKQRLQVLHLLILILPEPNRNALKALLEFLRKVVAREQHNKMTLRNVSTVMAPNL 432
            + ++R++ L  LI  LP      LK L+  L+ +    + NKM  RN++ V  P L
Sbjct: 914 EDARERMRTLRKLIRDLPGHYYETLKFLVGHLKTIADHSEKNKMEPRNLALVFGPTL 970


>gi|33188433 deleted in liver cancer 1 isoform 1 [Homo sapiens]
          Length = 1528

 Score = 88.2 bits (217), Expect = 2e-17
 Identities = 64/220 (29%), Positives = 106/220 (48%), Gaps = 21/220 (9%)

Query: 226  SLQDMRKVPSLALIELTALCD------------ILGLDLKRSKAGKWKAAETRLFGVPLD 273
            S+  M  +   +L++LTAL +             +   +KR K   +K  +  +FGVPL 
Sbjct: 1024 SVAQMNLLQKYSLLKLTALLEKYTPSNKHGFSWAVPKFMKRIKVPDYK--DRSVFGVPLT 1081

Query: 274  SLLEADHKVLPSTQVPLVLQALLSCLEKRGLDMEGILRVPGSQARVKGLEQKLERDFYAG 333
              ++   + LP +     +Q  +  L    LD  G+ R  G ++R++ L Q  E      
Sbjct: 1082 VNVQRTGQPLPQS-----IQQAMRYLRNHCLDQVGLFRKSGVKSRIQALRQMNEGAIDCV 1136

Query: 334  LFSWDEVHHNDASDLLKRFIRKLPTPLLTAEYLPAFAVVPNIPNLKQRLQVLHLLILILP 393
             +     +  D +D+LK++ R LP PL+T +    F  +       QRLQ +   I++LP
Sbjct: 1137 NYEGQSAY--DVADMLKQYFRDLPEPLMTNKLSETFLQIYQYVPKDQRLQAIKAAIMLLP 1194

Query: 394  EPNRNALKALLEFLRKVVAREQHNKMTLRNVSTVMAPNLF 433
            + NR  L+ LL FL  V A  + N+MT  N++  +AP+LF
Sbjct: 1195 DENREVLQTLLYFLSDVTAAVKENQMTPTNLAVCLAPSLF 1234


>gi|33188437 deleted in liver cancer 1 isoform 2 [Homo sapiens]
          Length = 1091

 Score = 88.2 bits (217), Expect = 2e-17
 Identities = 64/220 (29%), Positives = 106/220 (48%), Gaps = 21/220 (9%)

Query: 226 SLQDMRKVPSLALIELTALCD------------ILGLDLKRSKAGKWKAAETRLFGVPLD 273
           S+  M  +   +L++LTAL +             +   +KR K   +K  +  +FGVPL 
Sbjct: 587 SVAQMNLLQKYSLLKLTALLEKYTPSNKHGFSWAVPKFMKRIKVPDYK--DRSVFGVPLT 644

Query: 274 SLLEADHKVLPSTQVPLVLQALLSCLEKRGLDMEGILRVPGSQARVKGLEQKLERDFYAG 333
             ++   + LP +     +Q  +  L    LD  G+ R  G ++R++ L Q  E      
Sbjct: 645 VNVQRTGQPLPQS-----IQQAMRYLRNHCLDQVGLFRKSGVKSRIQALRQMNEGAIDCV 699

Query: 334 LFSWDEVHHNDASDLLKRFIRKLPTPLLTAEYLPAFAVVPNIPNLKQRLQVLHLLILILP 393
            +     +  D +D+LK++ R LP PL+T +    F  +       QRLQ +   I++LP
Sbjct: 700 NYEGQSAY--DVADMLKQYFRDLPEPLMTNKLSETFLQIYQYVPKDQRLQAIKAAIMLLP 757

Query: 394 EPNRNALKALLEFLRKVVAREQHNKMTLRNVSTVMAPNLF 433
           + NR  L+ LL FL  V A  + N+MT  N++  +AP+LF
Sbjct: 758 DENREVLQTLLYFLSDVTAAVKENQMTPTNLAVCLAPSLF 797


>gi|67906814 Rho GTPase activating protein 19 [Homo sapiens]
          Length = 494

 Score = 87.0 bits (214), Expect = 5e-17
 Identities = 52/143 (36%), Positives = 78/143 (54%), Gaps = 13/143 (9%)

Query: 302 RGLDMEGILRVPGSQARVKGLEQKLERDFYAGLFSWDEVHHNDASDLLKRFIRKLPTPLL 361
           + L +EG+ RVPG+  R + L   L       L S  E H ND + LLK F+ +LP PLL
Sbjct: 134 KNLRVEGLFRVPGNSVRQQILRDALNNGTDIDLES-GEFHSNDVATLLKMFLGELPEPLL 192

Query: 362 TAEYLPAFAVVP------------NIPNLKQRLQVLHLLILILPEPNRNALKALLEFLRK 409
           T ++  A   +             NIP+  ++++ L LL LILP PNRN LK LL+ L +
Sbjct: 193 THKHFNAHLKIADLMQFDDKGNKTNIPDKDRQIEALQLLFLILPPPNRNLLKLLLDLLYQ 252

Query: 410 VVAREQHNKMTLRNVSTVMAPNL 432
              ++  NKM+  N++ + AP++
Sbjct: 253 TAKKQDKNKMSAYNLALMFAPHV 275


>gi|42475970 synapse defective 1, Rho GTPase, homolog 1 [Homo
           sapiens]
          Length = 735

 Score = 87.0 bits (214), Expect = 5e-17
 Identities = 69/216 (31%), Positives = 108/216 (50%), Gaps = 10/216 (4%)

Query: 263 AETRLFGVPLDSLLEADHKVLPSTQVPLVLQALLSCLEKRGLDMEGILRVPGSQARVKGL 322
           AE R+FG+PL  L+E +    P  QVPL++Q  +  +E+RGL + G+ R+ GS A  K L
Sbjct: 391 AEPRVFGLPLPLLVERER---PPGQVPLIIQKCVGQIERRGLRVVGLYRLCGSAAVKKEL 447

Query: 323 EQKLERDFYAGLFSWDEVHH-NDASDLLKRFIRKLPTPLLTAEYLPAF--AVVPNIPN-L 378
               ERD  A   S D     N  + +LK ++R+LPTPL+T         A+  + PN +
Sbjct: 448 RDAFERDSAAVCLSEDLYPDINVITGILKDYLRELPTPLITQPLYKVVLEAMARDPPNRV 507

Query: 379 KQRLQVLHLLILILPEPNRNALKALLEFLRKVVAREQHNKMTLRNVSTVMAPNLFLHQGR 438
               +    L+  LP+  R  L  LL+ LR V +   +N+MT +N++    P + L   +
Sbjct: 508 PPTTEGTRGLLSCLPDVERATLTLLLDHLRLVSSFHAYNRMTPQNLAVCFGP-VLLPARQ 566

Query: 439 PPKLPKGKEKQLAEGAAEVVQIMVHYQDLLWTVASF 474
            P  P+ +      G A  V    H + L + + S+
Sbjct: 567 APTRPRARSS--GPGLASAVDFKHHIEVLHYLLQSW 600


>gi|7382480 Rho GTPase activating protein 6 isoform 4 [Homo sapiens]
          Length = 771

 Score = 86.7 bits (213), Expect = 6e-17
 Identities = 81/260 (31%), Positives = 113/260 (43%), Gaps = 36/260 (13%)

Query: 287 QVPLVLQALLSCLEKRGLDMEGILRVPGSQARVKGLEQKLERDFYAGLFSWDEVHHNDAS 346
           QVP ++ +    LEK GL   GI RV  S+ RV+ L ++ +R     L     VH  D +
Sbjct: 206 QVPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVSLEEEHSVH--DVA 263

Query: 347 DLLKRFIRKLPTPLLTAEYLPAFAVVPNIPNLKQRLQVLHLLILILPEPNRNALKALLEF 406
            LLK F+R +P PLLT E   AF +   +   +++L  L LLI +LP  N + L  LL+F
Sbjct: 264 ALLKEFLRDMPDPLLTRELYTAF-INTLLLEPEEQLGTLQLLIYLLPPCNCDTLHRLLQF 322

Query: 407 LRKVVAREQH------------NKMTLRNVSTVMAPNLFLHQGRPPKLPKGKEKQLAEGA 454
           L  +VAR               NKMT  N++T+  PNL   Q    K    +    AE +
Sbjct: 323 L-SIVARHADDNISKDGQEVTGNKMTSLNLATIFGPNLLHKQKSSDKEFSVQSSARAEES 381

Query: 455 A---EVVQIMVHYQDLLWTVASFLVAQV-----------------RKLNDSSSRRPQLCD 494
                VVQ M+   + L+ V   L  +V                 RK + SSS      +
Sbjct: 382 TAIIAVVQKMIENYEALFMVPPDLQNEVLISLLETDPDVVDYLLRRKASQSSSPDMLQSE 441

Query: 495 AGLKTWLRRMHADRDKAGDG 514
                  R    D +KA  G
Sbjct: 442 VSFSVGGRHSSTDSNKASSG 461


>gi|95091988 Rho GTPase activating protein 6 isoform 3 [Homo
           sapiens]
          Length = 765

 Score = 86.7 bits (213), Expect = 6e-17
 Identities = 81/260 (31%), Positives = 113/260 (43%), Gaps = 36/260 (13%)

Query: 287 QVPLVLQALLSCLEKRGLDMEGILRVPGSQARVKGLEQKLERDFYAGLFSWDEVHHNDAS 346
           QVP ++ +    LEK GL   GI RV  S+ RV+ L ++ +R     L     VH  D +
Sbjct: 409 QVPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVSLEEEHSVH--DVA 466

Query: 347 DLLKRFIRKLPTPLLTAEYLPAFAVVPNIPNLKQRLQVLHLLILILPEPNRNALKALLEF 406
            LLK F+R +P PLLT E   AF +   +   +++L  L LLI +LP  N + L  LL+F
Sbjct: 467 ALLKEFLRDMPDPLLTRELYTAF-INTLLLEPEEQLGTLQLLIYLLPPCNCDTLHRLLQF 525

Query: 407 LRKVVAREQH------------NKMTLRNVSTVMAPNLFLHQGRPPKLPKGKEKQLAEGA 454
           L  +VAR               NKMT  N++T+  PNL   Q    K    +    AE +
Sbjct: 526 L-SIVARHADDNISKDGQEVTGNKMTSLNLATIFGPNLLHKQKSSDKEFSVQSSARAEES 584

Query: 455 A---EVVQIMVHYQDLLWTVASFLVAQV-----------------RKLNDSSSRRPQLCD 494
                VVQ M+   + L+ V   L  +V                 RK + SSS      +
Sbjct: 585 TAIIAVVQKMIENYEALFMVPPDLQNEVLISLLETDPDVVDYLLRRKASQSSSPDMLQSE 644

Query: 495 AGLKTWLRRMHADRDKAGDG 514
                  R    D +KA  G
Sbjct: 645 VSFSVGGRHSSTDSNKASSG 664


>gi|95091875 Rho GTPase activating protein 6 isoform 1 [Homo
           sapiens]
          Length = 974

 Score = 86.7 bits (213), Expect = 6e-17
 Identities = 81/260 (31%), Positives = 113/260 (43%), Gaps = 36/260 (13%)

Query: 287 QVPLVLQALLSCLEKRGLDMEGILRVPGSQARVKGLEQKLERDFYAGLFSWDEVHHNDAS 346
           QVP ++ +    LEK GL   GI RV  S+ RV+ L ++ +R     L     VH  D +
Sbjct: 409 QVPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVSLEEEHSVH--DVA 466

Query: 347 DLLKRFIRKLPTPLLTAEYLPAFAVVPNIPNLKQRLQVLHLLILILPEPNRNALKALLEF 406
            LLK F+R +P PLLT E   AF +   +   +++L  L LLI +LP  N + L  LL+F
Sbjct: 467 ALLKEFLRDMPDPLLTRELYTAF-INTLLLEPEEQLGTLQLLIYLLPPCNCDTLHRLLQF 525

Query: 407 LRKVVAREQH------------NKMTLRNVSTVMAPNLFLHQGRPPKLPKGKEKQLAEGA 454
           L  +VAR               NKMT  N++T+  PNL   Q    K    +    AE +
Sbjct: 526 L-SIVARHADDNISKDGQEVTGNKMTSLNLATIFGPNLLHKQKSSDKEFSVQSSARAEES 584

Query: 455 A---EVVQIMVHYQDLLWTVASFLVAQV-----------------RKLNDSSSRRPQLCD 494
                VVQ M+   + L+ V   L  +V                 RK + SSS      +
Sbjct: 585 TAIIAVVQKMIENYEALFMVPPDLQNEVLISLLETDPDVVDYLLRRKASQSSSPDMLQSE 644

Query: 495 AGLKTWLRRMHADRDKAGDG 514
                  R    D +KA  G
Sbjct: 645 VSFSVGGRHSSTDSNKASSG 664


>gi|122939147 Rho GTPase activating protein 9 isoform 1 [Homo
           sapiens]
          Length = 731

 Score = 86.3 bits (212), Expect = 8e-17
 Identities = 59/188 (31%), Positives = 95/188 (50%), Gaps = 27/188 (14%)

Query: 266 RLFGVPLDSLLEADHKVLPSTQVPLVLQALLSCLEKRGLDMEGILRVPGSQARVKGLEQK 325
           ++FG  L+SL + +   +PS      L+  ++ ++KRGLD++GI RV G+ A V+ L   
Sbjct: 519 QVFGCQLESLCQREGDTVPS-----FLRLCIAAVDKRGLDVDGIYRVSGNLAVVQKLRFL 573

Query: 326 LERDFYA---GLF-----------------SWDEVHHNDASDLLKRFIRKLPTPLLTAEY 365
           ++R+      G +                  WD++H    +  LK F+R+LP PL+    
Sbjct: 574 VDRERAVTSDGRYVFPEQPGQEGRLDLDSTEWDDIHV--VTGALKLFLRELPQPLVPPLL 631

Query: 366 LPAFAVVPNIPNLKQRLQVLHLLILILPEPNRNALKALLEFLRKVVAREQHNKMTLRNVS 425
           LP F     +   +Q L  +  LI  +P+PN + L+ LLE L +V+A    N+MT  N+ 
Sbjct: 632 LPHFRAALALSESEQCLSQIQELIGSMPKPNHDTLRYLLEHLCRVIAHSDKNRMTPHNLG 691

Query: 426 TVMAPNLF 433
            V  P LF
Sbjct: 692 IVFGPTLF 699


>gi|122939149 Rho GTPase activating protein 9 isoform 3 [Homo
           sapiens]
          Length = 547

 Score = 86.3 bits (212), Expect = 8e-17
 Identities = 59/188 (31%), Positives = 95/188 (50%), Gaps = 27/188 (14%)

Query: 266 RLFGVPLDSLLEADHKVLPSTQVPLVLQALLSCLEKRGLDMEGILRVPGSQARVKGLEQK 325
           ++FG  L+SL + +   +PS      L+  ++ ++KRGLD++GI RV G+ A V+ L   
Sbjct: 335 QVFGCQLESLCQREGDTVPS-----FLRLCIAAVDKRGLDVDGIYRVSGNLAVVQKLRFL 389

Query: 326 LERDFYA---GLF-----------------SWDEVHHNDASDLLKRFIRKLPTPLLTAEY 365
           ++R+      G +                  WD++H    +  LK F+R+LP PL+    
Sbjct: 390 VDRERAVTSDGRYVFPEQPGQEGRLDLDSTEWDDIHV--VTGALKLFLRELPQPLVPPLL 447

Query: 366 LPAFAVVPNIPNLKQRLQVLHLLILILPEPNRNALKALLEFLRKVVAREQHNKMTLRNVS 425
           LP F     +   +Q L  +  LI  +P+PN + L+ LLE L +V+A    N+MT  N+ 
Sbjct: 448 LPHFRAALALSESEQCLSQIQELIGSMPKPNHDTLRYLLEHLCRVIAHSDKNRMTPHNLG 507

Query: 426 TVMAPNLF 433
            V  P LF
Sbjct: 508 IVFGPTLF 515


>gi|82546845 breakpoint cluster region isoform 2 [Homo sapiens]
          Length = 1227

 Score = 84.0 bits (206), Expect = 4e-16
 Identities = 60/218 (27%), Positives = 107/218 (49%), Gaps = 9/218 (4%)

Query: 252  LKRSKAGKWKAAETRLFGVPLDSLLEADHKVLPSTQVPLVLQALLSCLEKRGLDMEGILR 311
            LKR  + K    +T +FGV +  + + +      ++VP +++  +  +E+RG++  GI R
Sbjct: 996  LKRMPSRK----QTGVFGVKIAVVTKRER-----SKVPYIVRQCVEEIERRGMEEVGIYR 1046

Query: 312  VPGSQARVKGLEQKLERDFYAGLFSWDEVHHNDASDLLKRFIRKLPTPLLTAEYLPAFAV 371
            V G    ++ L+   + +         E+  N  +  LK + R+LP PL T E+ P FA 
Sbjct: 1047 VSGVATDIQALKAAFDVNNKDVSVMMSEMDVNAIAGTLKLYFRELPEPLFTDEFYPNFAE 1106

Query: 372  VPNIPNLKQRLQVLHLLILILPEPNRNALKALLEFLRKVVAREQHNKMTLRNVSTVMAPN 431
               + +   +   +  L+L LPE N      LL+ L++V  +E  NKM+L N++TV  P 
Sbjct: 1107 GIALSDPVAKESCMLNLLLSLPEANLLTFLFLLDHLKRVAEKEAVNKMSLHNLATVFGPT 1166

Query: 432  LFLHQGRPPKLPKGKEKQLAEGAAEVVQIMVHYQDLLW 469
            L     +  KLP    + +    +  +++M   Q LL+
Sbjct: 1167 LLRPSEKESKLPANPSQPITMTDSWSLEVMSQVQVLLY 1204


>gi|82546843 breakpoint cluster region isoform 1 [Homo sapiens]
          Length = 1271

 Score = 84.0 bits (206), Expect = 4e-16
 Identities = 60/218 (27%), Positives = 107/218 (49%), Gaps = 9/218 (4%)

Query: 252  LKRSKAGKWKAAETRLFGVPLDSLLEADHKVLPSTQVPLVLQALLSCLEKRGLDMEGILR 311
            LKR  + K    +T +FGV +  + + +      ++VP +++  +  +E+RG++  GI R
Sbjct: 1040 LKRMPSRK----QTGVFGVKIAVVTKRER-----SKVPYIVRQCVEEIERRGMEEVGIYR 1090

Query: 312  VPGSQARVKGLEQKLERDFYAGLFSWDEVHHNDASDLLKRFIRKLPTPLLTAEYLPAFAV 371
            V G    ++ L+   + +         E+  N  +  LK + R+LP PL T E+ P FA 
Sbjct: 1091 VSGVATDIQALKAAFDVNNKDVSVMMSEMDVNAIAGTLKLYFRELPEPLFTDEFYPNFAE 1150

Query: 372  VPNIPNLKQRLQVLHLLILILPEPNRNALKALLEFLRKVVAREQHNKMTLRNVSTVMAPN 431
               + +   +   +  L+L LPE N      LL+ L++V  +E  NKM+L N++TV  P 
Sbjct: 1151 GIALSDPVAKESCMLNLLLSLPEANLLTFLFLLDHLKRVAEKEAVNKMSLHNLATVFGPT 1210

Query: 432  LFLHQGRPPKLPKGKEKQLAEGAAEVVQIMVHYQDLLW 469
            L     +  KLP    + +    +  +++M   Q LL+
Sbjct: 1211 LLRPSEKESKLPANPSQPITMTDSWSLEVMSQVQVLLY 1248


>gi|226693398 Rho GTPase activating protein 27 isoform b [Homo
           sapiens]
          Length = 521

 Score = 83.6 bits (205), Expect = 5e-16
 Identities = 50/180 (27%), Positives = 93/180 (51%), Gaps = 9/180 (5%)

Query: 266 RLFGVPLDSLLEADHKVLPSTQVPLVLQALLSCLEKRGLDMEGILRVPGSQARVKGLEQK 325
           ++FG  L +L E +      ++VP  +Q  +  +E RGLD++G+ R+ G+ A ++ L  K
Sbjct: 325 QVFGCALAALCERER-----SRVPRFVQQCIRAVEARGLDIDGLYRISGNLATIQKLRYK 379

Query: 326 LERDFYAGLFS--WDEVHHNDASDLLKRFIRKLPTPLLTAEYLPAFAVVPNIPNLKQRLQ 383
           ++ D    L    W++VH    +  LK F R+LP PL    +   F     + +  +R +
Sbjct: 380 VDHDERLDLDDGRWEDVHV--ITGALKLFFRELPEPLFPFSHFRQFIAAIKLQDQARRSR 437

Query: 384 VLHLLILILPEPNRNALKALLEFLRKVVAREQHNKMTLRNVSTVMAPNLFLHQGRPPKLP 443
            +  L+  LP PN + L+ L + L +V+   + N+M++++V+ V  P L   +     +P
Sbjct: 438 CVRDLVRSLPAPNHDTLRMLFQHLCRVIEHGEQNRMSVQSVAIVFGPTLLRPEVEETSMP 497


>gi|40548322 Rho GTPase activating protein 27 isoform a [Homo
           sapiens]
          Length = 548

 Score = 83.6 bits (205), Expect = 5e-16
 Identities = 50/180 (27%), Positives = 93/180 (51%), Gaps = 9/180 (5%)

Query: 266 RLFGVPLDSLLEADHKVLPSTQVPLVLQALLSCLEKRGLDMEGILRVPGSQARVKGLEQK 325
           ++FG  L +L E +      ++VP  +Q  +  +E RGLD++G+ R+ G+ A ++ L  K
Sbjct: 352 QVFGCALAALCERER-----SRVPRFVQQCIRAVEARGLDIDGLYRISGNLATIQKLRYK 406

Query: 326 LERDFYAGLFS--WDEVHHNDASDLLKRFIRKLPTPLLTAEYLPAFAVVPNIPNLKQRLQ 383
           ++ D    L    W++VH    +  LK F R+LP PL    +   F     + +  +R +
Sbjct: 407 VDHDERLDLDDGRWEDVHV--ITGALKLFFRELPEPLFPFSHFRQFIAAIKLQDQARRSR 464

Query: 384 VLHLLILILPEPNRNALKALLEFLRKVVAREQHNKMTLRNVSTVMAPNLFLHQGRPPKLP 443
            +  L+  LP PN + L+ L + L +V+   + N+M++++V+ V  P L   +     +P
Sbjct: 465 CVRDLVRSLPAPNHDTLRMLFQHLCRVIEHGEQNRMSVQSVAIVFGPTLLRPEVEETSMP 524


>gi|203097003 Rho GTPase activating protein 21 [Homo sapiens]
          Length = 1958

 Score = 82.8 bits (203), Expect = 9e-16
 Identities = 59/175 (33%), Positives = 83/175 (47%), Gaps = 9/175 (5%)

Query: 261  KAAETRLFGVPLDSLLEADHKVLPSTQVPLVLQALLSCLEKRGLDMEGILRVPGSQARVK 320
            K   T  FGV LD    A      +  +PL++      +E+RGL+  GI RVPG+ A + 
Sbjct: 1138 KPTATGTFGVRLDDCPPAH----TNRYIPLIVDICCKLVEERGLEYTGIYRVPGNNAAIS 1193

Query: 321  GLEQKLER---DFYAGLFSWDEVHHNDASDLLKRFIRKLPTPLLTAEYLPAFAVVPNIPN 377
             ++++L +   D       W ++  N  S LLK F RKLP PL T +    F       +
Sbjct: 1194 SMQEELNKGMADIDIQDDKWRDL--NVISSLLKSFFRKLPEPLFTNDKYADFIEANRKED 1251

Query: 378  LKQRLQVLHLLILILPEPNRNALKALLEFLRKVVAREQHNKMTLRNVSTVMAPNL 432
               RL+ L  LI  LPE +   LK L   L+ V    + NKM  RN++ V  P L
Sbjct: 1252 PLDRLKTLKRLIHDLPEHHYETLKFLSAHLKTVAENSEKNKMEPRNLAIVFGPTL 1306


>gi|229094128 active breakpoint cluster region-related  protein
           isoform c [Homo sapiens]
          Length = 813

 Score = 82.0 bits (201), Expect = 1e-15
 Identities = 65/225 (28%), Positives = 115/225 (51%), Gaps = 28/225 (12%)

Query: 250 LDLKRSKAGKWKAAETRLFGVPLDSLLEADHKVLPSTQVPLVLQALLSCLEKRGLDMEGI 309
           + LKR+ + K    +T +FGV +  + + +      ++VP +++  +  +EKRG++  GI
Sbjct: 585 MSLKRTPSKK----QTGVFGVKISVVTKRER-----SKVPYIVRQCVEEVEKRGIEEVGI 635

Query: 310 LRVPGSQARVKGLEQKLERDFYAGLFSWDEVHHNDASDLLKRFIRKLPTPLLTAEYLPAF 369
            R+ G    ++ L+   + +    L    ++  N  +  LK + R+LP PLLT    PAF
Sbjct: 636 YRISGVATDIQALKAVFDANNKDILLMLSDMDINAIAGTLKLYFRELPEPLLTDRLYPAF 695

Query: 370 --AVVPNIPNLKQRLQVLHLLILILPEPNRNALKALLEFLRKVVAREQHNKMTLRNVSTV 427
              +  + P  K+   ++HLL   LP+PN      LLE L++V  +E  NKM+L N++TV
Sbjct: 696 MEGIALSDPAAKENC-MMHLL-RSLPDPNLITFLFLLEHLKRVAEKEPINKMSLHNLATV 753

Query: 428 MAPNLFLHQGRPPKLPKGKEKQLAEGAAEV--------VQIMVHY 464
             P L     RP ++   + K     AA++        VQ++++Y
Sbjct: 754 FGPTLL----RPSEV---ESKAHLTSAADIWSHDVMAQVQVLLYY 791


>gi|38679957 active breakpoint cluster region-related  protein
           isoform a [Homo sapiens]
          Length = 859

 Score = 82.0 bits (201), Expect = 1e-15
 Identities = 65/225 (28%), Positives = 115/225 (51%), Gaps = 28/225 (12%)

Query: 250 LDLKRSKAGKWKAAETRLFGVPLDSLLEADHKVLPSTQVPLVLQALLSCLEKRGLDMEGI 309
           + LKR+ + K    +T +FGV +  + + +      ++VP +++  +  +EKRG++  GI
Sbjct: 631 MSLKRTPSKK----QTGVFGVKISVVTKRER-----SKVPYIVRQCVEEVEKRGIEEVGI 681

Query: 310 LRVPGSQARVKGLEQKLERDFYAGLFSWDEVHHNDASDLLKRFIRKLPTPLLTAEYLPAF 369
            R+ G    ++ L+   + +    L    ++  N  +  LK + R+LP PLLT    PAF
Sbjct: 682 YRISGVATDIQALKAVFDANNKDILLMLSDMDINAIAGTLKLYFRELPEPLLTDRLYPAF 741

Query: 370 --AVVPNIPNLKQRLQVLHLLILILPEPNRNALKALLEFLRKVVAREQHNKMTLRNVSTV 427
              +  + P  K+   ++HLL   LP+PN      LLE L++V  +E  NKM+L N++TV
Sbjct: 742 MEGIALSDPAAKENC-MMHLL-RSLPDPNLITFLFLLEHLKRVAEKEPINKMSLHNLATV 799

Query: 428 MAPNLFLHQGRPPKLPKGKEKQLAEGAAEV--------VQIMVHY 464
             P L     RP ++   + K     AA++        VQ++++Y
Sbjct: 800 FGPTLL----RPSEV---ESKAHLTSAADIWSHDVMAQVQVLLYY 837


>gi|38679954 active breakpoint cluster region-related  protein
           isoform b [Homo sapiens]
          Length = 822

 Score = 82.0 bits (201), Expect = 1e-15
 Identities = 65/225 (28%), Positives = 115/225 (51%), Gaps = 28/225 (12%)

Query: 250 LDLKRSKAGKWKAAETRLFGVPLDSLLEADHKVLPSTQVPLVLQALLSCLEKRGLDMEGI 309
           + LKR+ + K    +T +FGV +  + + +      ++VP +++  +  +EKRG++  GI
Sbjct: 594 MSLKRTPSKK----QTGVFGVKISVVTKRER-----SKVPYIVRQCVEEVEKRGIEEVGI 644

Query: 310 LRVPGSQARVKGLEQKLERDFYAGLFSWDEVHHNDASDLLKRFIRKLPTPLLTAEYLPAF 369
            R+ G    ++ L+   + +    L    ++  N  +  LK + R+LP PLLT    PAF
Sbjct: 645 YRISGVATDIQALKAVFDANNKDILLMLSDMDINAIAGTLKLYFRELPEPLLTDRLYPAF 704

Query: 370 --AVVPNIPNLKQRLQVLHLLILILPEPNRNALKALLEFLRKVVAREQHNKMTLRNVSTV 427
              +  + P  K+   ++HLL   LP+PN      LLE L++V  +E  NKM+L N++TV
Sbjct: 705 MEGIALSDPAAKENC-MMHLL-RSLPDPNLITFLFLLEHLKRVAEKEPINKMSLHNLATV 762

Query: 428 MAPNLFLHQGRPPKLPKGKEKQLAEGAAEV--------VQIMVHY 464
             P L     RP ++   + K     AA++        VQ++++Y
Sbjct: 763 FGPTLL----RPSEV---ESKAHLTSAADIWSHDVMAQVQVLLYY 800


>gi|21264337 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
            [Homo sapiens]
          Length = 1544

 Score = 81.6 bits (200), Expect = 2e-15
 Identities = 49/151 (32%), Positives = 78/151 (51%)

Query: 288  VPLVLQALLSCLEKRGLDMEGILRVPGSQARVKGLEQKLERDFYAGLFSWDEVHHNDASD 347
            +P+++ A +S + + GL +EG+ R  G++AR   L  +  RD  +      E    D +D
Sbjct: 919  IPIIVDACISFVTQHGLRLEGVYRKGGARARSLRLLAEFRRDARSVKLRPGEHFVEDVTD 978

Query: 348  LLKRFIRKLPTPLLTAEYLPAFAVVPNIPNLKQRLQVLHLLILILPEPNRNALKALLEFL 407
             LKRF R+L  P+ +A  LP +     +P   QRL+    +I  LP  NR  L  L+  L
Sbjct: 979  TLKRFFRELDDPVTSARLLPRWREAAELPQKNQRLEKYKDVIGCLPRVNRRTLATLIGHL 1038

Query: 408  RKVVAREQHNKMTLRNVSTVMAPNLFLHQGR 438
             +V      N+M  RN++ + AP++F   GR
Sbjct: 1039 YRVQKCAALNQMCTRNLALLFAPSVFQTDGR 1069


>gi|5803145 ralA binding protein 1 [Homo sapiens]
          Length = 655

 Score = 80.9 bits (198), Expect = 3e-15
 Identities = 49/166 (29%), Positives = 87/166 (52%), Gaps = 4/166 (2%)

Query: 267 LFGVPLDSLLEADHKVLPSTQVPLVLQALLSCLEKRGLDMEGILRVPGSQARVKGLEQKL 326
           +FG+PL   +E    +    ++P V +  +  +EK G+  EGI RV G +++V  L+   
Sbjct: 189 IFGIPLADAVERT-MMYDGIRLPAVFRECIDYVEKYGMKCEGIYRVSGIKSKVDELKAAY 247

Query: 327 ERDFYAGLFSWDEVHHNDASDLLKRFIRKLPTPLLTAEYLPAFAVVPNIPNLKQRLQVLH 386
           +R+    L   ++   N  + LLK+++R LP  LLT E +P F          +++Q   
Sbjct: 248 DREESTNL---EDYEPNTVASLLKQYLRDLPENLLTKELMPRFEEACGRTTETEKVQEFQ 304

Query: 387 LLILILPEPNRNALKALLEFLRKVVAREQHNKMTLRNVSTVMAPNL 432
            L+  LPE N   +  L+  +  V+A+E   KM ++N+S V++P +
Sbjct: 305 RLLKELPECNYLLISWLIVHMDHVIAKELETKMNIQNISIVLSPTV 350


>gi|188497642 ARHGAP15 [Homo sapiens]
          Length = 475

 Score = 80.5 bits (197), Expect = 4e-15
 Identities = 52/173 (30%), Positives = 86/173 (49%), Gaps = 17/173 (9%)

Query: 266 RLFGVPLDSLLEADHKVLPSTQVPLVLQALLSCLEKRGLDMEGILRVPGSQARVKGL--- 322
           ++FG  L  + E ++       VP  ++  +  +EKRGLD++GI RV G+ A ++ L   
Sbjct: 277 QIFGSHLHKVCERENST-----VPWFVKQCIEAVEKRGLDVDGIYRVSGNLATIQKLRFI 331

Query: 323 ---EQKLERDFYAGLFSWDEVHHNDASDLLKRFIRKLPTPLLTAEYLPAFAVVPNIPNLK 379
              E+KL  D       W+++H    +  LK F R+LP PL    +   F       +  
Sbjct: 332 VNQEEKLNLDDS----QWEDIHV--VTGALKMFFRELPEPLFPYSFFEQFVEAIKKQDNN 385

Query: 380 QRLQVLHLLILILPEPNRNALKALLEFLRKVVAREQHNKMTLRNVSTVMAPNL 432
            R++ +  L+  LP PNR+ +K L   L K+VA+   N M+ +++  V  P L
Sbjct: 386 TRIEAVKSLVQKLPPPNRDTMKVLFGHLTKIVAKASKNLMSTQSLGIVFGPTL 438


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.134    0.394 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,678,288
Number of Sequences: 37866
Number of extensions: 1135387
Number of successful extensions: 3850
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 98
Number of HSP's successfully gapped in prelim test: 36
Number of HSP's that attempted gapping in prelim test: 3624
Number of HSP's gapped (non-prelim): 161
length of query: 622
length of database: 18,247,518
effective HSP length: 108
effective length of query: 514
effective length of database: 14,157,990
effective search space: 7277206860
effective search space used: 7277206860
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 65 (29.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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