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Search of human proteins with 239746488
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|239746488 PREDICTED: Rho GTPase-activating protein 18-like
[Homo sapiens]
(622 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|239757488 PREDICTED: chromosome 20 open reading frame 95 [Hom... 1240 0.0
gi|239752003 PREDICTED: chromosome 20 open reading frame 95 [Hom... 1240 0.0
gi|239746488 PREDICTED: Rho GTPase-activating protein 18-like [H... 1240 0.0
gi|39932589 Rho GTPase activating protein 18 [Homo sapiens] 414 e-115
gi|59710113 Rho GTPase activating protein 28 isoform a [Homo sap... 302 7e-82
gi|59710111 Rho GTPase activating protein 28 isoform b [Homo sap... 253 4e-67
gi|41281907 StAR-related lipid transfer (START) domain containin... 92 2e-18
gi|16445031 StAR-related lipid transfer (START) domain containin... 92 2e-18
gi|41281898 StAR-related lipid transfer (START) domain containin... 92 2e-18
gi|224458284 Rho GTPase activating protein 23 [Homo sapiens] 90 7e-18
gi|33188433 deleted in liver cancer 1 isoform 1 [Homo sapiens] 88 2e-17
gi|33188437 deleted in liver cancer 1 isoform 2 [Homo sapiens] 88 2e-17
gi|67906814 Rho GTPase activating protein 19 [Homo sapiens] 87 5e-17
gi|42475970 synapse defective 1, Rho GTPase, homolog 1 [Homo sap... 87 5e-17
gi|7382480 Rho GTPase activating protein 6 isoform 4 [Homo sapiens] 87 6e-17
gi|95091988 Rho GTPase activating protein 6 isoform 3 [Homo sapi... 87 6e-17
gi|95091875 Rho GTPase activating protein 6 isoform 1 [Homo sapi... 87 6e-17
gi|122939147 Rho GTPase activating protein 9 isoform 1 [Homo sap... 86 8e-17
gi|122939149 Rho GTPase activating protein 9 isoform 3 [Homo sap... 86 8e-17
gi|82546845 breakpoint cluster region isoform 2 [Homo sapiens] 84 4e-16
gi|82546843 breakpoint cluster region isoform 1 [Homo sapiens] 84 4e-16
gi|226693398 Rho GTPase activating protein 27 isoform b [Homo sa... 84 5e-16
gi|40548322 Rho GTPase activating protein 27 isoform a [Homo sap... 84 5e-16
gi|203097003 Rho GTPase activating protein 21 [Homo sapiens] 83 9e-16
gi|229094128 active breakpoint cluster region-related protein i... 82 1e-15
gi|38679957 active breakpoint cluster region-related protein is... 82 1e-15
gi|38679954 active breakpoint cluster region-related protein is... 82 1e-15
gi|21264337 ArfGAP with RhoGAP domain, ankyrin repeat and PH dom... 82 2e-15
gi|5803145 ralA binding protein 1 [Homo sapiens] 81 3e-15
gi|188497642 ARHGAP15 [Homo sapiens] 80 4e-15
>gi|239757488 PREDICTED: chromosome 20 open reading frame 95 [Homo
sapiens]
Length = 622
Score = 1240 bits (3208), Expect = 0.0
Identities = 622/622 (100%), Positives = 622/622 (100%)
Query: 1 MDQLPQKNLLRLHPAGSAGCSTGVESSSMDGFWMEVEQIQQRDELREEDSGGNEGQLPEE 60
MDQLPQKNLLRLHPAGSAGCSTGVESSSMDGFWMEVEQIQQRDELREEDSGGNEGQLPEE
Sbjct: 1 MDQLPQKNLLRLHPAGSAGCSTGVESSSMDGFWMEVEQIQQRDELREEDSGGNEGQLPEE 60
Query: 61 GEAESQWLQDTGLSGLLGGLGLDGDHQELLSTLTQTQVAAVCRRLDIYARSVRRQHKTPV 120
GEAESQWLQDTGLSGLLGGLGLDGDHQELLSTLTQTQVAAVCRRLDIYARSVRRQHKTPV
Sbjct: 61 GEAESQWLQDTGLSGLLGGLGLDGDHQELLSTLTQTQVAAVCRRLDIYARSVRRQHKTPV 120
Query: 121 RDVRDVFGVFNSGKMSSENGDSGMKGAQLSSGASKFPPAAEPGGLQEQAGREEAFNMDSA 180
RDVRDVFGVFNSGKMSSENGDSGMKGAQLSSGASKFPPAAEPGGLQEQAGREEAFNMDSA
Sbjct: 121 RDVRDVFGVFNSGKMSSENGDSGMKGAQLSSGASKFPPAAEPGGLQEQAGREEAFNMDSA 180
Query: 181 YSEQAAVLLQRSRPSRGGTSAWGKCSLPKFTVPKGRLGVTRIGDLSLQDMRKVPSLALIE 240
YSEQAAVLLQRSRPSRGGTSAWGKCSLPKFTVPKGRLGVTRIGDLSLQDMRKVPSLALIE
Sbjct: 181 YSEQAAVLLQRSRPSRGGTSAWGKCSLPKFTVPKGRLGVTRIGDLSLQDMRKVPSLALIE 240
Query: 241 LTALCDILGLDLKRSKAGKWKAAETRLFGVPLDSLLEADHKVLPSTQVPLVLQALLSCLE 300
LTALCDILGLDLKRSKAGKWKAAETRLFGVPLDSLLEADHKVLPSTQVPLVLQALLSCLE
Sbjct: 241 LTALCDILGLDLKRSKAGKWKAAETRLFGVPLDSLLEADHKVLPSTQVPLVLQALLSCLE 300
Query: 301 KRGLDMEGILRVPGSQARVKGLEQKLERDFYAGLFSWDEVHHNDASDLLKRFIRKLPTPL 360
KRGLDMEGILRVPGSQARVKGLEQKLERDFYAGLFSWDEVHHNDASDLLKRFIRKLPTPL
Sbjct: 301 KRGLDMEGILRVPGSQARVKGLEQKLERDFYAGLFSWDEVHHNDASDLLKRFIRKLPTPL 360
Query: 361 LTAEYLPAFAVVPNIPNLKQRLQVLHLLILILPEPNRNALKALLEFLRKVVAREQHNKMT 420
LTAEYLPAFAVVPNIPNLKQRLQVLHLLILILPEPNRNALKALLEFLRKVVAREQHNKMT
Sbjct: 361 LTAEYLPAFAVVPNIPNLKQRLQVLHLLILILPEPNRNALKALLEFLRKVVAREQHNKMT 420
Query: 421 LRNVSTVMAPNLFLHQGRPPKLPKGKEKQLAEGAAEVVQIMVHYQDLLWTVASFLVAQVR 480
LRNVSTVMAPNLFLHQGRPPKLPKGKEKQLAEGAAEVVQIMVHYQDLLWTVASFLVAQVR
Sbjct: 421 LRNVSTVMAPNLFLHQGRPPKLPKGKEKQLAEGAAEVVQIMVHYQDLLWTVASFLVAQVR 480
Query: 481 KLNDSSSRRPQLCDAGLKTWLRRMHADRDKAGDGLEATPKVAKIQVVWPIKDPLKVPLTP 540
KLNDSSSRRPQLCDAGLKTWLRRMHADRDKAGDGLEATPKVAKIQVVWPIKDPLKVPLTP
Sbjct: 481 KLNDSSSRRPQLCDAGLKTWLRRMHADRDKAGDGLEATPKVAKIQVVWPIKDPLKVPLTP 540
Query: 541 STKVAHVLRQFTEHLSPGSKGQEDSEDMDSLLLHHRSMESANILLYEVGGNINEHRLDPD 600
STKVAHVLRQFTEHLSPGSKGQEDSEDMDSLLLHHRSMESANILLYEVGGNINEHRLDPD
Sbjct: 541 STKVAHVLRQFTEHLSPGSKGQEDSEDMDSLLLHHRSMESANILLYEVGGNINEHRLDPD 600
Query: 601 AYLLDLYRANPHGEWVLKQNPT 622
AYLLDLYRANPHGEWVLKQNPT
Sbjct: 601 AYLLDLYRANPHGEWVLKQNPT 622
>gi|239752003 PREDICTED: chromosome 20 open reading frame 95 [Homo
sapiens]
Length = 622
Score = 1240 bits (3208), Expect = 0.0
Identities = 622/622 (100%), Positives = 622/622 (100%)
Query: 1 MDQLPQKNLLRLHPAGSAGCSTGVESSSMDGFWMEVEQIQQRDELREEDSGGNEGQLPEE 60
MDQLPQKNLLRLHPAGSAGCSTGVESSSMDGFWMEVEQIQQRDELREEDSGGNEGQLPEE
Sbjct: 1 MDQLPQKNLLRLHPAGSAGCSTGVESSSMDGFWMEVEQIQQRDELREEDSGGNEGQLPEE 60
Query: 61 GEAESQWLQDTGLSGLLGGLGLDGDHQELLSTLTQTQVAAVCRRLDIYARSVRRQHKTPV 120
GEAESQWLQDTGLSGLLGGLGLDGDHQELLSTLTQTQVAAVCRRLDIYARSVRRQHKTPV
Sbjct: 61 GEAESQWLQDTGLSGLLGGLGLDGDHQELLSTLTQTQVAAVCRRLDIYARSVRRQHKTPV 120
Query: 121 RDVRDVFGVFNSGKMSSENGDSGMKGAQLSSGASKFPPAAEPGGLQEQAGREEAFNMDSA 180
RDVRDVFGVFNSGKMSSENGDSGMKGAQLSSGASKFPPAAEPGGLQEQAGREEAFNMDSA
Sbjct: 121 RDVRDVFGVFNSGKMSSENGDSGMKGAQLSSGASKFPPAAEPGGLQEQAGREEAFNMDSA 180
Query: 181 YSEQAAVLLQRSRPSRGGTSAWGKCSLPKFTVPKGRLGVTRIGDLSLQDMRKVPSLALIE 240
YSEQAAVLLQRSRPSRGGTSAWGKCSLPKFTVPKGRLGVTRIGDLSLQDMRKVPSLALIE
Sbjct: 181 YSEQAAVLLQRSRPSRGGTSAWGKCSLPKFTVPKGRLGVTRIGDLSLQDMRKVPSLALIE 240
Query: 241 LTALCDILGLDLKRSKAGKWKAAETRLFGVPLDSLLEADHKVLPSTQVPLVLQALLSCLE 300
LTALCDILGLDLKRSKAGKWKAAETRLFGVPLDSLLEADHKVLPSTQVPLVLQALLSCLE
Sbjct: 241 LTALCDILGLDLKRSKAGKWKAAETRLFGVPLDSLLEADHKVLPSTQVPLVLQALLSCLE 300
Query: 301 KRGLDMEGILRVPGSQARVKGLEQKLERDFYAGLFSWDEVHHNDASDLLKRFIRKLPTPL 360
KRGLDMEGILRVPGSQARVKGLEQKLERDFYAGLFSWDEVHHNDASDLLKRFIRKLPTPL
Sbjct: 301 KRGLDMEGILRVPGSQARVKGLEQKLERDFYAGLFSWDEVHHNDASDLLKRFIRKLPTPL 360
Query: 361 LTAEYLPAFAVVPNIPNLKQRLQVLHLLILILPEPNRNALKALLEFLRKVVAREQHNKMT 420
LTAEYLPAFAVVPNIPNLKQRLQVLHLLILILPEPNRNALKALLEFLRKVVAREQHNKMT
Sbjct: 361 LTAEYLPAFAVVPNIPNLKQRLQVLHLLILILPEPNRNALKALLEFLRKVVAREQHNKMT 420
Query: 421 LRNVSTVMAPNLFLHQGRPPKLPKGKEKQLAEGAAEVVQIMVHYQDLLWTVASFLVAQVR 480
LRNVSTVMAPNLFLHQGRPPKLPKGKEKQLAEGAAEVVQIMVHYQDLLWTVASFLVAQVR
Sbjct: 421 LRNVSTVMAPNLFLHQGRPPKLPKGKEKQLAEGAAEVVQIMVHYQDLLWTVASFLVAQVR 480
Query: 481 KLNDSSSRRPQLCDAGLKTWLRRMHADRDKAGDGLEATPKVAKIQVVWPIKDPLKVPLTP 540
KLNDSSSRRPQLCDAGLKTWLRRMHADRDKAGDGLEATPKVAKIQVVWPIKDPLKVPLTP
Sbjct: 481 KLNDSSSRRPQLCDAGLKTWLRRMHADRDKAGDGLEATPKVAKIQVVWPIKDPLKVPLTP 540
Query: 541 STKVAHVLRQFTEHLSPGSKGQEDSEDMDSLLLHHRSMESANILLYEVGGNINEHRLDPD 600
STKVAHVLRQFTEHLSPGSKGQEDSEDMDSLLLHHRSMESANILLYEVGGNINEHRLDPD
Sbjct: 541 STKVAHVLRQFTEHLSPGSKGQEDSEDMDSLLLHHRSMESANILLYEVGGNINEHRLDPD 600
Query: 601 AYLLDLYRANPHGEWVLKQNPT 622
AYLLDLYRANPHGEWVLKQNPT
Sbjct: 601 AYLLDLYRANPHGEWVLKQNPT 622
>gi|239746488 PREDICTED: Rho GTPase-activating protein 18-like [Homo
sapiens]
Length = 622
Score = 1240 bits (3208), Expect = 0.0
Identities = 622/622 (100%), Positives = 622/622 (100%)
Query: 1 MDQLPQKNLLRLHPAGSAGCSTGVESSSMDGFWMEVEQIQQRDELREEDSGGNEGQLPEE 60
MDQLPQKNLLRLHPAGSAGCSTGVESSSMDGFWMEVEQIQQRDELREEDSGGNEGQLPEE
Sbjct: 1 MDQLPQKNLLRLHPAGSAGCSTGVESSSMDGFWMEVEQIQQRDELREEDSGGNEGQLPEE 60
Query: 61 GEAESQWLQDTGLSGLLGGLGLDGDHQELLSTLTQTQVAAVCRRLDIYARSVRRQHKTPV 120
GEAESQWLQDTGLSGLLGGLGLDGDHQELLSTLTQTQVAAVCRRLDIYARSVRRQHKTPV
Sbjct: 61 GEAESQWLQDTGLSGLLGGLGLDGDHQELLSTLTQTQVAAVCRRLDIYARSVRRQHKTPV 120
Query: 121 RDVRDVFGVFNSGKMSSENGDSGMKGAQLSSGASKFPPAAEPGGLQEQAGREEAFNMDSA 180
RDVRDVFGVFNSGKMSSENGDSGMKGAQLSSGASKFPPAAEPGGLQEQAGREEAFNMDSA
Sbjct: 121 RDVRDVFGVFNSGKMSSENGDSGMKGAQLSSGASKFPPAAEPGGLQEQAGREEAFNMDSA 180
Query: 181 YSEQAAVLLQRSRPSRGGTSAWGKCSLPKFTVPKGRLGVTRIGDLSLQDMRKVPSLALIE 240
YSEQAAVLLQRSRPSRGGTSAWGKCSLPKFTVPKGRLGVTRIGDLSLQDMRKVPSLALIE
Sbjct: 181 YSEQAAVLLQRSRPSRGGTSAWGKCSLPKFTVPKGRLGVTRIGDLSLQDMRKVPSLALIE 240
Query: 241 LTALCDILGLDLKRSKAGKWKAAETRLFGVPLDSLLEADHKVLPSTQVPLVLQALLSCLE 300
LTALCDILGLDLKRSKAGKWKAAETRLFGVPLDSLLEADHKVLPSTQVPLVLQALLSCLE
Sbjct: 241 LTALCDILGLDLKRSKAGKWKAAETRLFGVPLDSLLEADHKVLPSTQVPLVLQALLSCLE 300
Query: 301 KRGLDMEGILRVPGSQARVKGLEQKLERDFYAGLFSWDEVHHNDASDLLKRFIRKLPTPL 360
KRGLDMEGILRVPGSQARVKGLEQKLERDFYAGLFSWDEVHHNDASDLLKRFIRKLPTPL
Sbjct: 301 KRGLDMEGILRVPGSQARVKGLEQKLERDFYAGLFSWDEVHHNDASDLLKRFIRKLPTPL 360
Query: 361 LTAEYLPAFAVVPNIPNLKQRLQVLHLLILILPEPNRNALKALLEFLRKVVAREQHNKMT 420
LTAEYLPAFAVVPNIPNLKQRLQVLHLLILILPEPNRNALKALLEFLRKVVAREQHNKMT
Sbjct: 361 LTAEYLPAFAVVPNIPNLKQRLQVLHLLILILPEPNRNALKALLEFLRKVVAREQHNKMT 420
Query: 421 LRNVSTVMAPNLFLHQGRPPKLPKGKEKQLAEGAAEVVQIMVHYQDLLWTVASFLVAQVR 480
LRNVSTVMAPNLFLHQGRPPKLPKGKEKQLAEGAAEVVQIMVHYQDLLWTVASFLVAQVR
Sbjct: 421 LRNVSTVMAPNLFLHQGRPPKLPKGKEKQLAEGAAEVVQIMVHYQDLLWTVASFLVAQVR 480
Query: 481 KLNDSSSRRPQLCDAGLKTWLRRMHADRDKAGDGLEATPKVAKIQVVWPIKDPLKVPLTP 540
KLNDSSSRRPQLCDAGLKTWLRRMHADRDKAGDGLEATPKVAKIQVVWPIKDPLKVPLTP
Sbjct: 481 KLNDSSSRRPQLCDAGLKTWLRRMHADRDKAGDGLEATPKVAKIQVVWPIKDPLKVPLTP 540
Query: 541 STKVAHVLRQFTEHLSPGSKGQEDSEDMDSLLLHHRSMESANILLYEVGGNINEHRLDPD 600
STKVAHVLRQFTEHLSPGSKGQEDSEDMDSLLLHHRSMESANILLYEVGGNINEHRLDPD
Sbjct: 541 STKVAHVLRQFTEHLSPGSKGQEDSEDMDSLLLHHRSMESANILLYEVGGNINEHRLDPD 600
Query: 601 AYLLDLYRANPHGEWVLKQNPT 622
AYLLDLYRANPHGEWVLKQNPT
Sbjct: 601 AYLLDLYRANPHGEWVLKQNPT 622
>gi|39932589 Rho GTPase activating protein 18 [Homo sapiens]
Length = 663
Score = 414 bits (1065), Expect = e-115
Identities = 239/618 (38%), Positives = 365/618 (59%), Gaps = 45/618 (7%)
Query: 24 VESSSMDGFWMEVEQIQQRDELREEDSGGNEGQLPEEGEAESQWLQDTGLSGLLGGLGLD 83
++ SM+ +W+E+E I++ E +ED + P+EGE E +WL++ GLS L G
Sbjct: 70 LDELSMEDYWIELENIKKSSENSQEDQEVVVVKEPDEGELEEEWLKEAGLSNLFGESA-- 127
Query: 84 GDHQE---LLSTLTQTQVAAVCRRLDIYARSVRRQHKT-PVRDVRDVFGVFNSGKMSSEN 139
GD QE LSTLT+TQ AAV +R++ ++++R+++K + DVRD+F + S E
Sbjct: 128 GDPQESIVFLSTLTRTQAAAVQKRVETVSQTLRKKNKQYQIPDVRDIFA---QQRESKET 184
Query: 140 GDSGMKGAQLSSGASKFPPAAEPGGL----------QEQAGREEAFNMDSAYSEQAAVLL 189
G + L + +K+ + +E E N++ +++EQA
Sbjct: 185 APGGTESQSLRTNENKYQGRDDEASNLVGEEKLIPPEETPAPETDINLEVSFAEQALNQK 244
Query: 190 QRSRPSRGGTSAWGKCSLPKFTVPKGRLGVTRIGDLSLQDMRKVPSLALIELTALCDILG 249
+ S+ + S +LP F +PK + G TRIGDL+ QDM+KV LALIELTAL D+LG
Sbjct: 245 ESSK-EKIQKSKGDDATLPSFRLPKDKTGTTRIGDLAPQDMKKVCHLALIELTALYDVLG 303
Query: 250 LDLKRSKAGKWKAAETRLFGVPLDSLLEADHKVLPSTQVPLVLQALLSCLEKRGLDMEGI 309
++LK+ KA K K ++ LF VPL +LLE D + +P ++PL+ Q L+S +E+RGL+ EG+
Sbjct: 304 IELKQQKAVKIKTKDSGLFCVPLTALLEQDQRKVPGMRIPLIFQKLISRIEERGLETEGL 363
Query: 310 LRVPGSQARVKGLEQKLERDFYAGLFSWDEVHHNDASDLLKRFIRKLPTPLLTAEYLPAF 369
LR+PG+ R+K L Q+LE FY G F+W+ V +DA+ LLK FIR+LP PLL+ EYL AF
Sbjct: 364 LRIPGAAIRIKNLCQELEAKFYEGTFNWESVKQHDAASLLKLFIRELPQPLLSVEYLKAF 423
Query: 370 AVVPNIPNLKQRLQVLHLLILILPEPNRNALKALLEFLRKVVAREQHNKMTLRNVSTVMA 429
V N+P KQ+LQ L+LL+++LP+ NR+ LKALLEFL++V+ ++ NKMT+ NV+ VMA
Sbjct: 424 QAVQNLPTKKQQLQALNLLVILLPDANRDTLKALLEFLQRVIDNKEKNKMTVMNVAMVMA 483
Query: 430 PNLFLHQGRPPKLPKGKEKQLAEGAAEVVQIMVHYQDLLWTVASFLVAQVRKLNDSSSRR 489
PNLF+ K + +E +A G A + +++ YQ LLWT+ F+V QVRK N + ++
Sbjct: 484 PNLFMCHALGLKSSEQREFVMAAGTANTMHLLIKYQKLLWTIPKFIVNQVRKQNTENHKK 543
Query: 490 PQLCDAGLKTWLRRMHADR------DKAGDGLEATPKVAKIQVVWPIKDPLKVPLTPSTK 543
+ +K L++M DR DK+ + + V ++Q K + + LT K
Sbjct: 544 DK---RAMKKLLKKMAYDREKYEKQDKSTNDADVPQGVIRVQAPHLSKVSMAIQLTEELK 600
Query: 544 VAHVLRQFTEHLSPGSKGQEDSEDMDSLLLHHRSMESANILLYEVGGNINEHRLDPDAYL 603
+ VL +F S + ++++ + LYE+GGNI E LD D Y+
Sbjct: 601 ASDVLARFLSQESGVA----------------QTLKKGEVFLYEIGGNIGERCLDDDTYM 644
Query: 604 LDLYRANPHGEWVLKQNP 621
DLY+ NP+ EWV+K P
Sbjct: 645 KDLYQLNPNAEWVIKSKP 662
>gi|59710113 Rho GTPase activating protein 28 isoform a [Homo
sapiens]
Length = 570
Score = 302 bits (773), Expect = 7e-82
Identities = 181/462 (39%), Positives = 265/462 (57%), Gaps = 37/462 (8%)
Query: 173 EAFNMDSAYSEQAAVLLQRSRPSRGGTSAWGKCSLPKFTVPKGRLGVTRIGDLSLQDMRK 232
E + + +YSE L+R++ + L KF V K R G+T GDLS +DM+K
Sbjct: 125 EELSFEVSYSEMVTEALKRNKLKKSEIKKEDYV-LTKFNVQKTRFGLTEAGDLSAEDMKK 183
Query: 233 VPSLALIELTALCDILGLDLKRSKAGKWKAAETRLFGVPLDSLLEADHKVLPSTQVPLVL 292
+ L+LIELTA D G+ LKR+K K K + +FGVPL LL+ D K P +VPLVL
Sbjct: 184 IRHLSLIELTAFFDAFGIQLKRNKTEKVKGRDNGIFGVPLTVLLDGDRKKDPGVKVPLVL 243
Query: 293 QALLSCLEKRGLDMEGILRVPGSQARVKGLEQKLERDFYAGLFSWDEVHHNDASDLLKRF 352
Q +E+ GL+ EGI R+ G A+VK ++L+ F A F WD++ H +A+ +LK F
Sbjct: 244 QKFFEKVEESGLESEGIFRLSGCTAKVKQYREELDAKFNADKFKWDKMCHREAAVMLKAF 303
Query: 353 IRKLPTPLLTAEYLPAF-AVVPNIPNLKQRLQVLHLLILILPEPNRNALKALLEFLRKVV 411
R+LPT L EY+PAF +++ P++K + Q LHL+++ LP+ NR+A +AL+ F KV+
Sbjct: 304 FRELPTSLFPVEYIPAFISLMERGPHVKVQFQALHLMVMALPDANRDAAQALMTFFNKVI 363
Query: 412 AREQHNKMTLRNVSTVMAPNLFLHQGRPPKLPKGKEKQLAEGAAEVVQIMVHYQDLLWTV 471
A E N+M+L N+STVMAPNLF + K +E LA AA ++++M+ YQ +LW V
Sbjct: 364 ANESKNRMSLWNISTVMAPNLFFSRS---KHSDYEELLLANTAAHIIRLMLKYQKILWKV 420
Query: 472 ASFLVAQVRKLNDSSS-RRPQLCDAGLKTWLRRMHADRD----KAGDGLEATPKVAK--- 523
SFL+ QVR++N+++ + QL ++ LRR +R+ K L+ +P +
Sbjct: 421 PSFLITQVRRMNEATMLLKKQL--PSVRKLLRRKTLERETASPKTSKVLQKSPSARRMSD 478
Query: 524 -----IQVVWPI--KDPLKVPLTPSTKVAHVLRQFTEHLSPGSKGQEDSEDMDSLLLHHR 576
I+V P+ K + + L TK +L +F S GS
Sbjct: 479 VPEGVIRVHAPLLSKVSMAIQLNNQTKAKDILAKFQYENSHGSS---------------E 523
Query: 577 SMESANILLYEVGGNINEHRLDPDAYLLDLYRANPHGEWVLK 618
++ N LYE+GGNI EH LDPDAY+LD+YR NP EWV+K
Sbjct: 524 CIKIQNQRLYEIGGNIGEHCLDPDAYILDVYRINPQAEWVIK 565
>gi|59710111 Rho GTPase activating protein 28 isoform b [Homo
sapiens]
Length = 563
Score = 253 bits (646), Expect = 4e-67
Identities = 144/354 (40%), Positives = 216/354 (61%), Gaps = 14/354 (3%)
Query: 173 EAFNMDSAYSEQAAVLLQRSRPSRGGTSAWGKCSLPKFTVPKGRLGVTRIGDLSLQDMRK 232
E + + +YSE L+R++ + L KF V K R G+T GDLS +DM+K
Sbjct: 125 EELSFEVSYSEMVTEALKRNKLKKSEIKKEDYV-LTKFNVQKTRFGLTEAGDLSAEDMKK 183
Query: 233 VPSLALIELTALCDILGLDLKRSKAGKWKAAETRLFGVPLDSLLEADHKVLPSTQVPLVL 292
+ L+LIELTA D G+ LKR+K K K + +FGVPL LL+ D K P +VPLVL
Sbjct: 184 IRHLSLIELTAFFDAFGIQLKRNKTEKVKGRDNGIFGVPLTVLLDGDRKKDPGVKVPLVL 243
Query: 293 QALLSCLEKRGLDMEGILRVPGSQARVKGLEQKLERDFYAGLFSWDEVHHNDASDLLKRF 352
Q +E+ GL+ EGI R+ G A+VK ++L+ F A F WD++ H +A+ +LK F
Sbjct: 244 QKFFEKVEESGLESEGIFRLSGCTAKVKQYREELDAKFNADKFKWDKMCHREAAVMLKAF 303
Query: 353 IRKLPTPLLTAEYLPAF-AVVPNIPNLKQRLQVLHLLILILPEPNRNALKALLEFLRKVV 411
R+LPT L EY+PAF +++ P++K + Q LHL+++ LP+ NR+A +AL+ F KV+
Sbjct: 304 FRELPTSLFPVEYIPAFISLMERGPHVKVQFQALHLMVMALPDANRDAAQALMTFFNKVI 363
Query: 412 AREQHNKMTLRNVSTVMAPNLFLHQGRPPKLPKGKEKQLAEGAAEVVQIMVHYQDLLWTV 471
A E N+M+L N+STVMAPNLF + K +E LA AA ++++M+ YQ +LW V
Sbjct: 364 ANESKNRMSLWNISTVMAPNLFFSRS---KHSDYEELLLANTAAHIIRLMLKYQKILWKV 420
Query: 472 ASFLVAQVRKLNDSSS-RRPQLCDAGLKTWLRRMHADRDKAGDGLEATPKVAKI 524
SFL+ QVR++N+++ + QL ++ LRR +R+ A+PK +K+
Sbjct: 421 PSFLITQVRRMNEATMLLKKQL--PSVRKLLRRKTLERE------TASPKTSKV 466
>gi|41281907 StAR-related lipid transfer (START) domain containing
13 isoform beta [Homo sapiens]
Length = 1105
Score = 91.7 bits (226), Expect = 2e-18
Identities = 74/242 (30%), Positives = 119/242 (49%), Gaps = 22/242 (9%)
Query: 252 LKRSKAGKWKAAETRLFGVPLDSLLEADHKVLPSTQVPLVLQALLSCLEKRGLDMEGILR 311
+KR K +K + +FGVPL ++ + LP + +Q L L LD G+ R
Sbjct: 639 MKRMKVPDYK--DKAVFGVPLIVHVQRTGQPLPQS-----IQQALRYLRSNCLDQVGLFR 691
Query: 312 VPGSQARVKGLEQKLERDFYAGLFSWDEVHHNDASDLLKRFIRKLPTPLLTAEYLPAFAV 371
G ++R+ L Q E + ++++ D +D++K+F R LP PL T + F
Sbjct: 692 KSGVKSRIHALRQMNEN--FPENVNYEDQSAYDVADMVKQFFRDLPEPLFTNKLSETFLH 749
Query: 372 VPNIPNLKQRLQVLHLLILILPEPNRNALKALLEFLRKVVAREQHNKMTLRNVSTVMAPN 431
+ + +QRLQ + IL+L + NR L+ LL FL VV + N+MT N++ +AP+
Sbjct: 750 IYQYVSKEQRLQAVQAAILLLADENREVLQTLLCFLNDVVNLVEENQMTPMNLAVCLAPS 809
Query: 432 LF-LHQGRPPKLPKGKEKQLAEG------------AAEVVQIMVHYQDLLWTVASFLVAQ 478
LF L+ + P+ +K+ A G AA+ + M+ D L+ V LVAQ
Sbjct: 810 LFHLNLLKKESSPRVIQKKYATGKPDQKDLNENLAAAQGLAHMIMECDRLFEVPHELVAQ 869
Query: 479 VR 480
R
Sbjct: 870 SR 871
>gi|16445031 StAR-related lipid transfer (START) domain containing
13 isoform gamma [Homo sapiens]
Length = 995
Score = 91.7 bits (226), Expect = 2e-18
Identities = 74/242 (30%), Positives = 119/242 (49%), Gaps = 22/242 (9%)
Query: 252 LKRSKAGKWKAAETRLFGVPLDSLLEADHKVLPSTQVPLVLQALLSCLEKRGLDMEGILR 311
+KR K +K + +FGVPL ++ + LP + +Q L L LD G+ R
Sbjct: 529 MKRMKVPDYK--DKAVFGVPLIVHVQRTGQPLPQS-----IQQALRYLRSNCLDQVGLFR 581
Query: 312 VPGSQARVKGLEQKLERDFYAGLFSWDEVHHNDASDLLKRFIRKLPTPLLTAEYLPAFAV 371
G ++R+ L Q E + ++++ D +D++K+F R LP PL T + F
Sbjct: 582 KSGVKSRIHALRQMNEN--FPENVNYEDQSAYDVADMVKQFFRDLPEPLFTNKLSETFLH 639
Query: 372 VPNIPNLKQRLQVLHLLILILPEPNRNALKALLEFLRKVVAREQHNKMTLRNVSTVMAPN 431
+ + +QRLQ + IL+L + NR L+ LL FL VV + N+MT N++ +AP+
Sbjct: 640 IYQYVSKEQRLQAVQAAILLLADENREVLQTLLCFLNDVVNLVEENQMTPMNLAVCLAPS 699
Query: 432 LF-LHQGRPPKLPKGKEKQLAEG------------AAEVVQIMVHYQDLLWTVASFLVAQ 478
LF L+ + P+ +K+ A G AA+ + M+ D L+ V LVAQ
Sbjct: 700 LFHLNLLKKESSPRVIQKKYATGKPDQKDLNENLAAAQGLAHMIMECDRLFEVPHELVAQ 759
Query: 479 VR 480
R
Sbjct: 760 SR 761
>gi|41281898 StAR-related lipid transfer (START) domain containing
13 isoform alpha [Homo sapiens]
Length = 1113
Score = 91.7 bits (226), Expect = 2e-18
Identities = 74/242 (30%), Positives = 119/242 (49%), Gaps = 22/242 (9%)
Query: 252 LKRSKAGKWKAAETRLFGVPLDSLLEADHKVLPSTQVPLVLQALLSCLEKRGLDMEGILR 311
+KR K +K + +FGVPL ++ + LP + +Q L L LD G+ R
Sbjct: 647 MKRMKVPDYK--DKAVFGVPLIVHVQRTGQPLPQS-----IQQALRYLRSNCLDQVGLFR 699
Query: 312 VPGSQARVKGLEQKLERDFYAGLFSWDEVHHNDASDLLKRFIRKLPTPLLTAEYLPAFAV 371
G ++R+ L Q E + ++++ D +D++K+F R LP PL T + F
Sbjct: 700 KSGVKSRIHALRQMNEN--FPENVNYEDQSAYDVADMVKQFFRDLPEPLFTNKLSETFLH 757
Query: 372 VPNIPNLKQRLQVLHLLILILPEPNRNALKALLEFLRKVVAREQHNKMTLRNVSTVMAPN 431
+ + +QRLQ + IL+L + NR L+ LL FL VV + N+MT N++ +AP+
Sbjct: 758 IYQYVSKEQRLQAVQAAILLLADENREVLQTLLCFLNDVVNLVEENQMTPMNLAVCLAPS 817
Query: 432 LF-LHQGRPPKLPKGKEKQLAEG------------AAEVVQIMVHYQDLLWTVASFLVAQ 478
LF L+ + P+ +K+ A G AA+ + M+ D L+ V LVAQ
Sbjct: 818 LFHLNLLKKESSPRVIQKKYATGKPDQKDLNENLAAAQGLAHMIMECDRLFEVPHELVAQ 877
Query: 479 VR 480
R
Sbjct: 878 SR 879
>gi|224458284 Rho GTPase activating protein 23 [Homo sapiens]
Length = 1397
Score = 89.7 bits (221), Expect = 7e-18
Identities = 63/177 (35%), Positives = 88/177 (49%), Gaps = 9/177 (5%)
Query: 259 KWKAAETRLFGVPLDSLLEADHKVLPSTQVPLVLQALLSCLEKRGLDMEGILRVPGSQAR 318
K K A R FGV L+ A + +VPL++ A +E RGL+ GI RVPG+ A
Sbjct: 800 KNKKAAPRAFGVRLEECQPATE----NQRVPLIVAACCRIVEARGLESTGIYRVPGNNAV 855
Query: 319 VKGLEQKLER---DFYAGLFSWDEVHHNDASDLLKRFIRKLPTPLLTAEYLPAFAVVPNI 375
V L+++L R D W ++ N S LLK F RKLP PL T + F I
Sbjct: 856 VSSLQEQLNRGPGDINLQDERWQDL--NVISSLLKSFFRKLPEPLFTDDKYNDFIEANRI 913
Query: 376 PNLKQRLQVLHLLILILPEPNRNALKALLEFLRKVVAREQHNKMTLRNVSTVMAPNL 432
+ ++R++ L LI LP LK L+ L+ + + NKM RN++ V P L
Sbjct: 914 EDARERMRTLRKLIRDLPGHYYETLKFLVGHLKTIADHSEKNKMEPRNLALVFGPTL 970
>gi|33188433 deleted in liver cancer 1 isoform 1 [Homo sapiens]
Length = 1528
Score = 88.2 bits (217), Expect = 2e-17
Identities = 64/220 (29%), Positives = 106/220 (48%), Gaps = 21/220 (9%)
Query: 226 SLQDMRKVPSLALIELTALCD------------ILGLDLKRSKAGKWKAAETRLFGVPLD 273
S+ M + +L++LTAL + + +KR K +K + +FGVPL
Sbjct: 1024 SVAQMNLLQKYSLLKLTALLEKYTPSNKHGFSWAVPKFMKRIKVPDYK--DRSVFGVPLT 1081
Query: 274 SLLEADHKVLPSTQVPLVLQALLSCLEKRGLDMEGILRVPGSQARVKGLEQKLERDFYAG 333
++ + LP + +Q + L LD G+ R G ++R++ L Q E
Sbjct: 1082 VNVQRTGQPLPQS-----IQQAMRYLRNHCLDQVGLFRKSGVKSRIQALRQMNEGAIDCV 1136
Query: 334 LFSWDEVHHNDASDLLKRFIRKLPTPLLTAEYLPAFAVVPNIPNLKQRLQVLHLLILILP 393
+ + D +D+LK++ R LP PL+T + F + QRLQ + I++LP
Sbjct: 1137 NYEGQSAY--DVADMLKQYFRDLPEPLMTNKLSETFLQIYQYVPKDQRLQAIKAAIMLLP 1194
Query: 394 EPNRNALKALLEFLRKVVAREQHNKMTLRNVSTVMAPNLF 433
+ NR L+ LL FL V A + N+MT N++ +AP+LF
Sbjct: 1195 DENREVLQTLLYFLSDVTAAVKENQMTPTNLAVCLAPSLF 1234
>gi|33188437 deleted in liver cancer 1 isoform 2 [Homo sapiens]
Length = 1091
Score = 88.2 bits (217), Expect = 2e-17
Identities = 64/220 (29%), Positives = 106/220 (48%), Gaps = 21/220 (9%)
Query: 226 SLQDMRKVPSLALIELTALCD------------ILGLDLKRSKAGKWKAAETRLFGVPLD 273
S+ M + +L++LTAL + + +KR K +K + +FGVPL
Sbjct: 587 SVAQMNLLQKYSLLKLTALLEKYTPSNKHGFSWAVPKFMKRIKVPDYK--DRSVFGVPLT 644
Query: 274 SLLEADHKVLPSTQVPLVLQALLSCLEKRGLDMEGILRVPGSQARVKGLEQKLERDFYAG 333
++ + LP + +Q + L LD G+ R G ++R++ L Q E
Sbjct: 645 VNVQRTGQPLPQS-----IQQAMRYLRNHCLDQVGLFRKSGVKSRIQALRQMNEGAIDCV 699
Query: 334 LFSWDEVHHNDASDLLKRFIRKLPTPLLTAEYLPAFAVVPNIPNLKQRLQVLHLLILILP 393
+ + D +D+LK++ R LP PL+T + F + QRLQ + I++LP
Sbjct: 700 NYEGQSAY--DVADMLKQYFRDLPEPLMTNKLSETFLQIYQYVPKDQRLQAIKAAIMLLP 757
Query: 394 EPNRNALKALLEFLRKVVAREQHNKMTLRNVSTVMAPNLF 433
+ NR L+ LL FL V A + N+MT N++ +AP+LF
Sbjct: 758 DENREVLQTLLYFLSDVTAAVKENQMTPTNLAVCLAPSLF 797
>gi|67906814 Rho GTPase activating protein 19 [Homo sapiens]
Length = 494
Score = 87.0 bits (214), Expect = 5e-17
Identities = 52/143 (36%), Positives = 78/143 (54%), Gaps = 13/143 (9%)
Query: 302 RGLDMEGILRVPGSQARVKGLEQKLERDFYAGLFSWDEVHHNDASDLLKRFIRKLPTPLL 361
+ L +EG+ RVPG+ R + L L L S E H ND + LLK F+ +LP PLL
Sbjct: 134 KNLRVEGLFRVPGNSVRQQILRDALNNGTDIDLES-GEFHSNDVATLLKMFLGELPEPLL 192
Query: 362 TAEYLPAFAVVP------------NIPNLKQRLQVLHLLILILPEPNRNALKALLEFLRK 409
T ++ A + NIP+ ++++ L LL LILP PNRN LK LL+ L +
Sbjct: 193 THKHFNAHLKIADLMQFDDKGNKTNIPDKDRQIEALQLLFLILPPPNRNLLKLLLDLLYQ 252
Query: 410 VVAREQHNKMTLRNVSTVMAPNL 432
++ NKM+ N++ + AP++
Sbjct: 253 TAKKQDKNKMSAYNLALMFAPHV 275
>gi|42475970 synapse defective 1, Rho GTPase, homolog 1 [Homo
sapiens]
Length = 735
Score = 87.0 bits (214), Expect = 5e-17
Identities = 69/216 (31%), Positives = 108/216 (50%), Gaps = 10/216 (4%)
Query: 263 AETRLFGVPLDSLLEADHKVLPSTQVPLVLQALLSCLEKRGLDMEGILRVPGSQARVKGL 322
AE R+FG+PL L+E + P QVPL++Q + +E+RGL + G+ R+ GS A K L
Sbjct: 391 AEPRVFGLPLPLLVERER---PPGQVPLIIQKCVGQIERRGLRVVGLYRLCGSAAVKKEL 447
Query: 323 EQKLERDFYAGLFSWDEVHH-NDASDLLKRFIRKLPTPLLTAEYLPAF--AVVPNIPN-L 378
ERD A S D N + +LK ++R+LPTPL+T A+ + PN +
Sbjct: 448 RDAFERDSAAVCLSEDLYPDINVITGILKDYLRELPTPLITQPLYKVVLEAMARDPPNRV 507
Query: 379 KQRLQVLHLLILILPEPNRNALKALLEFLRKVVAREQHNKMTLRNVSTVMAPNLFLHQGR 438
+ L+ LP+ R L LL+ LR V + +N+MT +N++ P + L +
Sbjct: 508 PPTTEGTRGLLSCLPDVERATLTLLLDHLRLVSSFHAYNRMTPQNLAVCFGP-VLLPARQ 566
Query: 439 PPKLPKGKEKQLAEGAAEVVQIMVHYQDLLWTVASF 474
P P+ + G A V H + L + + S+
Sbjct: 567 APTRPRARSS--GPGLASAVDFKHHIEVLHYLLQSW 600
>gi|7382480 Rho GTPase activating protein 6 isoform 4 [Homo sapiens]
Length = 771
Score = 86.7 bits (213), Expect = 6e-17
Identities = 81/260 (31%), Positives = 113/260 (43%), Gaps = 36/260 (13%)
Query: 287 QVPLVLQALLSCLEKRGLDMEGILRVPGSQARVKGLEQKLERDFYAGLFSWDEVHHNDAS 346
QVP ++ + LEK GL GI RV S+ RV+ L ++ +R L VH D +
Sbjct: 206 QVPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVSLEEEHSVH--DVA 263
Query: 347 DLLKRFIRKLPTPLLTAEYLPAFAVVPNIPNLKQRLQVLHLLILILPEPNRNALKALLEF 406
LLK F+R +P PLLT E AF + + +++L L LLI +LP N + L LL+F
Sbjct: 264 ALLKEFLRDMPDPLLTRELYTAF-INTLLLEPEEQLGTLQLLIYLLPPCNCDTLHRLLQF 322
Query: 407 LRKVVAREQH------------NKMTLRNVSTVMAPNLFLHQGRPPKLPKGKEKQLAEGA 454
L +VAR NKMT N++T+ PNL Q K + AE +
Sbjct: 323 L-SIVARHADDNISKDGQEVTGNKMTSLNLATIFGPNLLHKQKSSDKEFSVQSSARAEES 381
Query: 455 A---EVVQIMVHYQDLLWTVASFLVAQV-----------------RKLNDSSSRRPQLCD 494
VVQ M+ + L+ V L +V RK + SSS +
Sbjct: 382 TAIIAVVQKMIENYEALFMVPPDLQNEVLISLLETDPDVVDYLLRRKASQSSSPDMLQSE 441
Query: 495 AGLKTWLRRMHADRDKAGDG 514
R D +KA G
Sbjct: 442 VSFSVGGRHSSTDSNKASSG 461
>gi|95091988 Rho GTPase activating protein 6 isoform 3 [Homo
sapiens]
Length = 765
Score = 86.7 bits (213), Expect = 6e-17
Identities = 81/260 (31%), Positives = 113/260 (43%), Gaps = 36/260 (13%)
Query: 287 QVPLVLQALLSCLEKRGLDMEGILRVPGSQARVKGLEQKLERDFYAGLFSWDEVHHNDAS 346
QVP ++ + LEK GL GI RV S+ RV+ L ++ +R L VH D +
Sbjct: 409 QVPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVSLEEEHSVH--DVA 466
Query: 347 DLLKRFIRKLPTPLLTAEYLPAFAVVPNIPNLKQRLQVLHLLILILPEPNRNALKALLEF 406
LLK F+R +P PLLT E AF + + +++L L LLI +LP N + L LL+F
Sbjct: 467 ALLKEFLRDMPDPLLTRELYTAF-INTLLLEPEEQLGTLQLLIYLLPPCNCDTLHRLLQF 525
Query: 407 LRKVVAREQH------------NKMTLRNVSTVMAPNLFLHQGRPPKLPKGKEKQLAEGA 454
L +VAR NKMT N++T+ PNL Q K + AE +
Sbjct: 526 L-SIVARHADDNISKDGQEVTGNKMTSLNLATIFGPNLLHKQKSSDKEFSVQSSARAEES 584
Query: 455 A---EVVQIMVHYQDLLWTVASFLVAQV-----------------RKLNDSSSRRPQLCD 494
VVQ M+ + L+ V L +V RK + SSS +
Sbjct: 585 TAIIAVVQKMIENYEALFMVPPDLQNEVLISLLETDPDVVDYLLRRKASQSSSPDMLQSE 644
Query: 495 AGLKTWLRRMHADRDKAGDG 514
R D +KA G
Sbjct: 645 VSFSVGGRHSSTDSNKASSG 664
>gi|95091875 Rho GTPase activating protein 6 isoform 1 [Homo
sapiens]
Length = 974
Score = 86.7 bits (213), Expect = 6e-17
Identities = 81/260 (31%), Positives = 113/260 (43%), Gaps = 36/260 (13%)
Query: 287 QVPLVLQALLSCLEKRGLDMEGILRVPGSQARVKGLEQKLERDFYAGLFSWDEVHHNDAS 346
QVP ++ + LEK GL GI RV S+ RV+ L ++ +R L VH D +
Sbjct: 409 QVPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVSLEEEHSVH--DVA 466
Query: 347 DLLKRFIRKLPTPLLTAEYLPAFAVVPNIPNLKQRLQVLHLLILILPEPNRNALKALLEF 406
LLK F+R +P PLLT E AF + + +++L L LLI +LP N + L LL+F
Sbjct: 467 ALLKEFLRDMPDPLLTRELYTAF-INTLLLEPEEQLGTLQLLIYLLPPCNCDTLHRLLQF 525
Query: 407 LRKVVAREQH------------NKMTLRNVSTVMAPNLFLHQGRPPKLPKGKEKQLAEGA 454
L +VAR NKMT N++T+ PNL Q K + AE +
Sbjct: 526 L-SIVARHADDNISKDGQEVTGNKMTSLNLATIFGPNLLHKQKSSDKEFSVQSSARAEES 584
Query: 455 A---EVVQIMVHYQDLLWTVASFLVAQV-----------------RKLNDSSSRRPQLCD 494
VVQ M+ + L+ V L +V RK + SSS +
Sbjct: 585 TAIIAVVQKMIENYEALFMVPPDLQNEVLISLLETDPDVVDYLLRRKASQSSSPDMLQSE 644
Query: 495 AGLKTWLRRMHADRDKAGDG 514
R D +KA G
Sbjct: 645 VSFSVGGRHSSTDSNKASSG 664
>gi|122939147 Rho GTPase activating protein 9 isoform 1 [Homo
sapiens]
Length = 731
Score = 86.3 bits (212), Expect = 8e-17
Identities = 59/188 (31%), Positives = 95/188 (50%), Gaps = 27/188 (14%)
Query: 266 RLFGVPLDSLLEADHKVLPSTQVPLVLQALLSCLEKRGLDMEGILRVPGSQARVKGLEQK 325
++FG L+SL + + +PS L+ ++ ++KRGLD++GI RV G+ A V+ L
Sbjct: 519 QVFGCQLESLCQREGDTVPS-----FLRLCIAAVDKRGLDVDGIYRVSGNLAVVQKLRFL 573
Query: 326 LERDFYA---GLF-----------------SWDEVHHNDASDLLKRFIRKLPTPLLTAEY 365
++R+ G + WD++H + LK F+R+LP PL+
Sbjct: 574 VDRERAVTSDGRYVFPEQPGQEGRLDLDSTEWDDIHV--VTGALKLFLRELPQPLVPPLL 631
Query: 366 LPAFAVVPNIPNLKQRLQVLHLLILILPEPNRNALKALLEFLRKVVAREQHNKMTLRNVS 425
LP F + +Q L + LI +P+PN + L+ LLE L +V+A N+MT N+
Sbjct: 632 LPHFRAALALSESEQCLSQIQELIGSMPKPNHDTLRYLLEHLCRVIAHSDKNRMTPHNLG 691
Query: 426 TVMAPNLF 433
V P LF
Sbjct: 692 IVFGPTLF 699
>gi|122939149 Rho GTPase activating protein 9 isoform 3 [Homo
sapiens]
Length = 547
Score = 86.3 bits (212), Expect = 8e-17
Identities = 59/188 (31%), Positives = 95/188 (50%), Gaps = 27/188 (14%)
Query: 266 RLFGVPLDSLLEADHKVLPSTQVPLVLQALLSCLEKRGLDMEGILRVPGSQARVKGLEQK 325
++FG L+SL + + +PS L+ ++ ++KRGLD++GI RV G+ A V+ L
Sbjct: 335 QVFGCQLESLCQREGDTVPS-----FLRLCIAAVDKRGLDVDGIYRVSGNLAVVQKLRFL 389
Query: 326 LERDFYA---GLF-----------------SWDEVHHNDASDLLKRFIRKLPTPLLTAEY 365
++R+ G + WD++H + LK F+R+LP PL+
Sbjct: 390 VDRERAVTSDGRYVFPEQPGQEGRLDLDSTEWDDIHV--VTGALKLFLRELPQPLVPPLL 447
Query: 366 LPAFAVVPNIPNLKQRLQVLHLLILILPEPNRNALKALLEFLRKVVAREQHNKMTLRNVS 425
LP F + +Q L + LI +P+PN + L+ LLE L +V+A N+MT N+
Sbjct: 448 LPHFRAALALSESEQCLSQIQELIGSMPKPNHDTLRYLLEHLCRVIAHSDKNRMTPHNLG 507
Query: 426 TVMAPNLF 433
V P LF
Sbjct: 508 IVFGPTLF 515
>gi|82546845 breakpoint cluster region isoform 2 [Homo sapiens]
Length = 1227
Score = 84.0 bits (206), Expect = 4e-16
Identities = 60/218 (27%), Positives = 107/218 (49%), Gaps = 9/218 (4%)
Query: 252 LKRSKAGKWKAAETRLFGVPLDSLLEADHKVLPSTQVPLVLQALLSCLEKRGLDMEGILR 311
LKR + K +T +FGV + + + + ++VP +++ + +E+RG++ GI R
Sbjct: 996 LKRMPSRK----QTGVFGVKIAVVTKRER-----SKVPYIVRQCVEEIERRGMEEVGIYR 1046
Query: 312 VPGSQARVKGLEQKLERDFYAGLFSWDEVHHNDASDLLKRFIRKLPTPLLTAEYLPAFAV 371
V G ++ L+ + + E+ N + LK + R+LP PL T E+ P FA
Sbjct: 1047 VSGVATDIQALKAAFDVNNKDVSVMMSEMDVNAIAGTLKLYFRELPEPLFTDEFYPNFAE 1106
Query: 372 VPNIPNLKQRLQVLHLLILILPEPNRNALKALLEFLRKVVAREQHNKMTLRNVSTVMAPN 431
+ + + + L+L LPE N LL+ L++V +E NKM+L N++TV P
Sbjct: 1107 GIALSDPVAKESCMLNLLLSLPEANLLTFLFLLDHLKRVAEKEAVNKMSLHNLATVFGPT 1166
Query: 432 LFLHQGRPPKLPKGKEKQLAEGAAEVVQIMVHYQDLLW 469
L + KLP + + + +++M Q LL+
Sbjct: 1167 LLRPSEKESKLPANPSQPITMTDSWSLEVMSQVQVLLY 1204
>gi|82546843 breakpoint cluster region isoform 1 [Homo sapiens]
Length = 1271
Score = 84.0 bits (206), Expect = 4e-16
Identities = 60/218 (27%), Positives = 107/218 (49%), Gaps = 9/218 (4%)
Query: 252 LKRSKAGKWKAAETRLFGVPLDSLLEADHKVLPSTQVPLVLQALLSCLEKRGLDMEGILR 311
LKR + K +T +FGV + + + + ++VP +++ + +E+RG++ GI R
Sbjct: 1040 LKRMPSRK----QTGVFGVKIAVVTKRER-----SKVPYIVRQCVEEIERRGMEEVGIYR 1090
Query: 312 VPGSQARVKGLEQKLERDFYAGLFSWDEVHHNDASDLLKRFIRKLPTPLLTAEYLPAFAV 371
V G ++ L+ + + E+ N + LK + R+LP PL T E+ P FA
Sbjct: 1091 VSGVATDIQALKAAFDVNNKDVSVMMSEMDVNAIAGTLKLYFRELPEPLFTDEFYPNFAE 1150
Query: 372 VPNIPNLKQRLQVLHLLILILPEPNRNALKALLEFLRKVVAREQHNKMTLRNVSTVMAPN 431
+ + + + L+L LPE N LL+ L++V +E NKM+L N++TV P
Sbjct: 1151 GIALSDPVAKESCMLNLLLSLPEANLLTFLFLLDHLKRVAEKEAVNKMSLHNLATVFGPT 1210
Query: 432 LFLHQGRPPKLPKGKEKQLAEGAAEVVQIMVHYQDLLW 469
L + KLP + + + +++M Q LL+
Sbjct: 1211 LLRPSEKESKLPANPSQPITMTDSWSLEVMSQVQVLLY 1248
>gi|226693398 Rho GTPase activating protein 27 isoform b [Homo
sapiens]
Length = 521
Score = 83.6 bits (205), Expect = 5e-16
Identities = 50/180 (27%), Positives = 93/180 (51%), Gaps = 9/180 (5%)
Query: 266 RLFGVPLDSLLEADHKVLPSTQVPLVLQALLSCLEKRGLDMEGILRVPGSQARVKGLEQK 325
++FG L +L E + ++VP +Q + +E RGLD++G+ R+ G+ A ++ L K
Sbjct: 325 QVFGCALAALCERER-----SRVPRFVQQCIRAVEARGLDIDGLYRISGNLATIQKLRYK 379
Query: 326 LERDFYAGLFS--WDEVHHNDASDLLKRFIRKLPTPLLTAEYLPAFAVVPNIPNLKQRLQ 383
++ D L W++VH + LK F R+LP PL + F + + +R +
Sbjct: 380 VDHDERLDLDDGRWEDVHV--ITGALKLFFRELPEPLFPFSHFRQFIAAIKLQDQARRSR 437
Query: 384 VLHLLILILPEPNRNALKALLEFLRKVVAREQHNKMTLRNVSTVMAPNLFLHQGRPPKLP 443
+ L+ LP PN + L+ L + L +V+ + N+M++++V+ V P L + +P
Sbjct: 438 CVRDLVRSLPAPNHDTLRMLFQHLCRVIEHGEQNRMSVQSVAIVFGPTLLRPEVEETSMP 497
>gi|40548322 Rho GTPase activating protein 27 isoform a [Homo
sapiens]
Length = 548
Score = 83.6 bits (205), Expect = 5e-16
Identities = 50/180 (27%), Positives = 93/180 (51%), Gaps = 9/180 (5%)
Query: 266 RLFGVPLDSLLEADHKVLPSTQVPLVLQALLSCLEKRGLDMEGILRVPGSQARVKGLEQK 325
++FG L +L E + ++VP +Q + +E RGLD++G+ R+ G+ A ++ L K
Sbjct: 352 QVFGCALAALCERER-----SRVPRFVQQCIRAVEARGLDIDGLYRISGNLATIQKLRYK 406
Query: 326 LERDFYAGLFS--WDEVHHNDASDLLKRFIRKLPTPLLTAEYLPAFAVVPNIPNLKQRLQ 383
++ D L W++VH + LK F R+LP PL + F + + +R +
Sbjct: 407 VDHDERLDLDDGRWEDVHV--ITGALKLFFRELPEPLFPFSHFRQFIAAIKLQDQARRSR 464
Query: 384 VLHLLILILPEPNRNALKALLEFLRKVVAREQHNKMTLRNVSTVMAPNLFLHQGRPPKLP 443
+ L+ LP PN + L+ L + L +V+ + N+M++++V+ V P L + +P
Sbjct: 465 CVRDLVRSLPAPNHDTLRMLFQHLCRVIEHGEQNRMSVQSVAIVFGPTLLRPEVEETSMP 524
>gi|203097003 Rho GTPase activating protein 21 [Homo sapiens]
Length = 1958
Score = 82.8 bits (203), Expect = 9e-16
Identities = 59/175 (33%), Positives = 83/175 (47%), Gaps = 9/175 (5%)
Query: 261 KAAETRLFGVPLDSLLEADHKVLPSTQVPLVLQALLSCLEKRGLDMEGILRVPGSQARVK 320
K T FGV LD A + +PL++ +E+RGL+ GI RVPG+ A +
Sbjct: 1138 KPTATGTFGVRLDDCPPAH----TNRYIPLIVDICCKLVEERGLEYTGIYRVPGNNAAIS 1193
Query: 321 GLEQKLER---DFYAGLFSWDEVHHNDASDLLKRFIRKLPTPLLTAEYLPAFAVVPNIPN 377
++++L + D W ++ N S LLK F RKLP PL T + F +
Sbjct: 1194 SMQEELNKGMADIDIQDDKWRDL--NVISSLLKSFFRKLPEPLFTNDKYADFIEANRKED 1251
Query: 378 LKQRLQVLHLLILILPEPNRNALKALLEFLRKVVAREQHNKMTLRNVSTVMAPNL 432
RL+ L LI LPE + LK L L+ V + NKM RN++ V P L
Sbjct: 1252 PLDRLKTLKRLIHDLPEHHYETLKFLSAHLKTVAENSEKNKMEPRNLAIVFGPTL 1306
>gi|229094128 active breakpoint cluster region-related protein
isoform c [Homo sapiens]
Length = 813
Score = 82.0 bits (201), Expect = 1e-15
Identities = 65/225 (28%), Positives = 115/225 (51%), Gaps = 28/225 (12%)
Query: 250 LDLKRSKAGKWKAAETRLFGVPLDSLLEADHKVLPSTQVPLVLQALLSCLEKRGLDMEGI 309
+ LKR+ + K +T +FGV + + + + ++VP +++ + +EKRG++ GI
Sbjct: 585 MSLKRTPSKK----QTGVFGVKISVVTKRER-----SKVPYIVRQCVEEVEKRGIEEVGI 635
Query: 310 LRVPGSQARVKGLEQKLERDFYAGLFSWDEVHHNDASDLLKRFIRKLPTPLLTAEYLPAF 369
R+ G ++ L+ + + L ++ N + LK + R+LP PLLT PAF
Sbjct: 636 YRISGVATDIQALKAVFDANNKDILLMLSDMDINAIAGTLKLYFRELPEPLLTDRLYPAF 695
Query: 370 --AVVPNIPNLKQRLQVLHLLILILPEPNRNALKALLEFLRKVVAREQHNKMTLRNVSTV 427
+ + P K+ ++HLL LP+PN LLE L++V +E NKM+L N++TV
Sbjct: 696 MEGIALSDPAAKENC-MMHLL-RSLPDPNLITFLFLLEHLKRVAEKEPINKMSLHNLATV 753
Query: 428 MAPNLFLHQGRPPKLPKGKEKQLAEGAAEV--------VQIMVHY 464
P L RP ++ + K AA++ VQ++++Y
Sbjct: 754 FGPTLL----RPSEV---ESKAHLTSAADIWSHDVMAQVQVLLYY 791
>gi|38679957 active breakpoint cluster region-related protein
isoform a [Homo sapiens]
Length = 859
Score = 82.0 bits (201), Expect = 1e-15
Identities = 65/225 (28%), Positives = 115/225 (51%), Gaps = 28/225 (12%)
Query: 250 LDLKRSKAGKWKAAETRLFGVPLDSLLEADHKVLPSTQVPLVLQALLSCLEKRGLDMEGI 309
+ LKR+ + K +T +FGV + + + + ++VP +++ + +EKRG++ GI
Sbjct: 631 MSLKRTPSKK----QTGVFGVKISVVTKRER-----SKVPYIVRQCVEEVEKRGIEEVGI 681
Query: 310 LRVPGSQARVKGLEQKLERDFYAGLFSWDEVHHNDASDLLKRFIRKLPTPLLTAEYLPAF 369
R+ G ++ L+ + + L ++ N + LK + R+LP PLLT PAF
Sbjct: 682 YRISGVATDIQALKAVFDANNKDILLMLSDMDINAIAGTLKLYFRELPEPLLTDRLYPAF 741
Query: 370 --AVVPNIPNLKQRLQVLHLLILILPEPNRNALKALLEFLRKVVAREQHNKMTLRNVSTV 427
+ + P K+ ++HLL LP+PN LLE L++V +E NKM+L N++TV
Sbjct: 742 MEGIALSDPAAKENC-MMHLL-RSLPDPNLITFLFLLEHLKRVAEKEPINKMSLHNLATV 799
Query: 428 MAPNLFLHQGRPPKLPKGKEKQLAEGAAEV--------VQIMVHY 464
P L RP ++ + K AA++ VQ++++Y
Sbjct: 800 FGPTLL----RPSEV---ESKAHLTSAADIWSHDVMAQVQVLLYY 837
>gi|38679954 active breakpoint cluster region-related protein
isoform b [Homo sapiens]
Length = 822
Score = 82.0 bits (201), Expect = 1e-15
Identities = 65/225 (28%), Positives = 115/225 (51%), Gaps = 28/225 (12%)
Query: 250 LDLKRSKAGKWKAAETRLFGVPLDSLLEADHKVLPSTQVPLVLQALLSCLEKRGLDMEGI 309
+ LKR+ + K +T +FGV + + + + ++VP +++ + +EKRG++ GI
Sbjct: 594 MSLKRTPSKK----QTGVFGVKISVVTKRER-----SKVPYIVRQCVEEVEKRGIEEVGI 644
Query: 310 LRVPGSQARVKGLEQKLERDFYAGLFSWDEVHHNDASDLLKRFIRKLPTPLLTAEYLPAF 369
R+ G ++ L+ + + L ++ N + LK + R+LP PLLT PAF
Sbjct: 645 YRISGVATDIQALKAVFDANNKDILLMLSDMDINAIAGTLKLYFRELPEPLLTDRLYPAF 704
Query: 370 --AVVPNIPNLKQRLQVLHLLILILPEPNRNALKALLEFLRKVVAREQHNKMTLRNVSTV 427
+ + P K+ ++HLL LP+PN LLE L++V +E NKM+L N++TV
Sbjct: 705 MEGIALSDPAAKENC-MMHLL-RSLPDPNLITFLFLLEHLKRVAEKEPINKMSLHNLATV 762
Query: 428 MAPNLFLHQGRPPKLPKGKEKQLAEGAAEV--------VQIMVHY 464
P L RP ++ + K AA++ VQ++++Y
Sbjct: 763 FGPTLL----RPSEV---ESKAHLTSAADIWSHDVMAQVQVLLYY 800
>gi|21264337 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
[Homo sapiens]
Length = 1544
Score = 81.6 bits (200), Expect = 2e-15
Identities = 49/151 (32%), Positives = 78/151 (51%)
Query: 288 VPLVLQALLSCLEKRGLDMEGILRVPGSQARVKGLEQKLERDFYAGLFSWDEVHHNDASD 347
+P+++ A +S + + GL +EG+ R G++AR L + RD + E D +D
Sbjct: 919 IPIIVDACISFVTQHGLRLEGVYRKGGARARSLRLLAEFRRDARSVKLRPGEHFVEDVTD 978
Query: 348 LLKRFIRKLPTPLLTAEYLPAFAVVPNIPNLKQRLQVLHLLILILPEPNRNALKALLEFL 407
LKRF R+L P+ +A LP + +P QRL+ +I LP NR L L+ L
Sbjct: 979 TLKRFFRELDDPVTSARLLPRWREAAELPQKNQRLEKYKDVIGCLPRVNRRTLATLIGHL 1038
Query: 408 RKVVAREQHNKMTLRNVSTVMAPNLFLHQGR 438
+V N+M RN++ + AP++F GR
Sbjct: 1039 YRVQKCAALNQMCTRNLALLFAPSVFQTDGR 1069
>gi|5803145 ralA binding protein 1 [Homo sapiens]
Length = 655
Score = 80.9 bits (198), Expect = 3e-15
Identities = 49/166 (29%), Positives = 87/166 (52%), Gaps = 4/166 (2%)
Query: 267 LFGVPLDSLLEADHKVLPSTQVPLVLQALLSCLEKRGLDMEGILRVPGSQARVKGLEQKL 326
+FG+PL +E + ++P V + + +EK G+ EGI RV G +++V L+
Sbjct: 189 IFGIPLADAVERT-MMYDGIRLPAVFRECIDYVEKYGMKCEGIYRVSGIKSKVDELKAAY 247
Query: 327 ERDFYAGLFSWDEVHHNDASDLLKRFIRKLPTPLLTAEYLPAFAVVPNIPNLKQRLQVLH 386
+R+ L ++ N + LLK+++R LP LLT E +P F +++Q
Sbjct: 248 DREESTNL---EDYEPNTVASLLKQYLRDLPENLLTKELMPRFEEACGRTTETEKVQEFQ 304
Query: 387 LLILILPEPNRNALKALLEFLRKVVAREQHNKMTLRNVSTVMAPNL 432
L+ LPE N + L+ + V+A+E KM ++N+S V++P +
Sbjct: 305 RLLKELPECNYLLISWLIVHMDHVIAKELETKMNIQNISIVLSPTV 350
>gi|188497642 ARHGAP15 [Homo sapiens]
Length = 475
Score = 80.5 bits (197), Expect = 4e-15
Identities = 52/173 (30%), Positives = 86/173 (49%), Gaps = 17/173 (9%)
Query: 266 RLFGVPLDSLLEADHKVLPSTQVPLVLQALLSCLEKRGLDMEGILRVPGSQARVKGL--- 322
++FG L + E ++ VP ++ + +EKRGLD++GI RV G+ A ++ L
Sbjct: 277 QIFGSHLHKVCERENST-----VPWFVKQCIEAVEKRGLDVDGIYRVSGNLATIQKLRFI 331
Query: 323 ---EQKLERDFYAGLFSWDEVHHNDASDLLKRFIRKLPTPLLTAEYLPAFAVVPNIPNLK 379
E+KL D W+++H + LK F R+LP PL + F +
Sbjct: 332 VNQEEKLNLDDS----QWEDIHV--VTGALKMFFRELPEPLFPYSFFEQFVEAIKKQDNN 385
Query: 380 QRLQVLHLLILILPEPNRNALKALLEFLRKVVAREQHNKMTLRNVSTVMAPNL 432
R++ + L+ LP PNR+ +K L L K+VA+ N M+ +++ V P L
Sbjct: 386 TRIEAVKSLVQKLPPPNRDTMKVLFGHLTKIVAKASKNLMSTQSLGIVFGPTL 438
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.134 0.394
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,678,288
Number of Sequences: 37866
Number of extensions: 1135387
Number of successful extensions: 3850
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 98
Number of HSP's successfully gapped in prelim test: 36
Number of HSP's that attempted gapping in prelim test: 3624
Number of HSP's gapped (non-prelim): 161
length of query: 622
length of database: 18,247,518
effective HSP length: 108
effective length of query: 514
effective length of database: 14,157,990
effective search space: 7277206860
effective search space used: 7277206860
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.