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Search of human proteins with 116734710
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|116734710 ATP-binding cassette, sub-family A member 3 [Homo
sapiens]
(1704 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|116734710 ATP-binding cassette, sub-family A member 3 [Homo s... 3402 0.0
gi|21536376 ATP-binding cassette, sub-family A member 1 [Homo sa... 538 e-152
gi|27262624 ATP-binding cassette, sub-family A , member 5 [Homo ... 534 e-151
gi|27262626 ATP-binding cassette, sub-family A , member 5 [Homo ... 534 e-151
gi|105990541 ATP-binding cassette, sub-family A member 4 [Homo s... 527 e-149
gi|45446740 ATP-binding cassette, sub-family A, member 2 isoform... 526 e-149
gi|47078218 ATP-binding cassette, sub-family A, member 2 isoform... 526 e-149
gi|150417984 ATP-binding cassette, sub-family A, member 7 [Homo ... 495 e-139
gi|27436953 ATP-binding cassette, sub-family A, member 6 [Homo s... 493 e-139
gi|27881501 ATP-binding cassette, sub-family A, member 12 isofor... 476 e-134
gi|30795238 ATP-binding cassette, sub-family A, member 12 isofor... 476 e-134
gi|31657092 ATP binding cassette, sub-family A (ABC1), member 13... 424 e-118
gi|27477115 ATP-binding cassette, sub-family A, member 9 [Homo s... 342 1e-93
gi|153792144 ATP-binding cassette, sub-family A, member 10 [Homo... 325 2e-88
gi|6005701 ATP-binding cassette, sub-family A member 8 [Homo sap... 298 4e-80
gi|169210363 PREDICTED: similar to hCG18626 [Homo sapiens] 218 5e-56
gi|169210679 PREDICTED: similar to hCG18626 [Homo sapiens] 218 5e-56
gi|169209894 PREDICTED: similar to hCG18626 [Homo sapiens] 218 5e-56
gi|11967971 ATP-binding cassette sub-family G member 8 [Homo sap... 91 1e-17
gi|171184400 ATP-binding cassette, sub-family B, member 10 [Homo... 91 1e-17
gi|42741659 ATP-binding cassette, subfamily B, member 1 [Homo sa... 90 2e-17
gi|148612844 ATP-binding cassette, sub-family B, member 5 [Homo ... 90 2e-17
gi|11967969 ATP-binding cassette sub-family G member 5 [Homo sap... 90 2e-17
gi|21536378 ATP-binding cassette, sub-family B (MDR/TAP), member... 87 2e-16
gi|9961250 ATP-binding cassette, subfamily B, member 4 isoform B... 86 3e-16
gi|9961252 ATP-binding cassette, subfamily B, member 4 isoform C... 86 3e-16
gi|4505771 ATP-binding cassette, subfamily B, member 4 isoform A... 86 3e-16
gi|156105685 ATP-binding cassette, sub-family B, member 8 [Homo ... 84 9e-16
gi|62526033 ATP-binding cassette, sub-family G, member 2 [Homo s... 83 3e-15
gi|46592978 ATP-binding cassette sub-family G member 1 isoform 7... 82 3e-15
>gi|116734710 ATP-binding cassette, sub-family A member 3 [Homo
sapiens]
Length = 1704
Score = 3402 bits (8822), Expect = 0.0
Identities = 1704/1704 (100%), Positives = 1704/1704 (100%)
Query: 1 MAVLRQLALLLWKNYTLQKRKVLVTVLELFLPLLFSGILIWLRLKIQSENVPNATIYPGQ 60
MAVLRQLALLLWKNYTLQKRKVLVTVLELFLPLLFSGILIWLRLKIQSENVPNATIYPGQ
Sbjct: 1 MAVLRQLALLLWKNYTLQKRKVLVTVLELFLPLLFSGILIWLRLKIQSENVPNATIYPGQ 60
Query: 61 SIQELPLFFTFPPPGDTWELAYIPSHSDAAKTVTETVRRALVINMRVRGFPSEKDFEDYI 120
SIQELPLFFTFPPPGDTWELAYIPSHSDAAKTVTETVRRALVINMRVRGFPSEKDFEDYI
Sbjct: 61 SIQELPLFFTFPPPGDTWELAYIPSHSDAAKTVTETVRRALVINMRVRGFPSEKDFEDYI 120
Query: 121 RYDNCSSSVLAAVVFEHPFNHSKEPLPLAVKYHLRFSYTRRNYMWTQTGSFFLKETEGWH 180
RYDNCSSSVLAAVVFEHPFNHSKEPLPLAVKYHLRFSYTRRNYMWTQTGSFFLKETEGWH
Sbjct: 121 RYDNCSSSVLAAVVFEHPFNHSKEPLPLAVKYHLRFSYTRRNYMWTQTGSFFLKETEGWH 180
Query: 181 TTSLFPLFPNPGPREPTSPDGGEPGYIREGFLAVQHAVDRAIMEYHADAATRQLFQRLTV 240
TTSLFPLFPNPGPREPTSPDGGEPGYIREGFLAVQHAVDRAIMEYHADAATRQLFQRLTV
Sbjct: 181 TTSLFPLFPNPGPREPTSPDGGEPGYIREGFLAVQHAVDRAIMEYHADAATRQLFQRLTV 240
Query: 241 TIKRFPYPPFIADPFLVAIQYQLPLLLLLSFTYTALTIARAVVQEKERRLKEYMRMMGLS 300
TIKRFPYPPFIADPFLVAIQYQLPLLLLLSFTYTALTIARAVVQEKERRLKEYMRMMGLS
Sbjct: 241 TIKRFPYPPFIADPFLVAIQYQLPLLLLLSFTYTALTIARAVVQEKERRLKEYMRMMGLS 300
Query: 301 SWLHWSAWFLLFFLFLLIAASFMTLLFCVKVKPNVAVLSRSDPSLVLAFLLCFAISTISF 360
SWLHWSAWFLLFFLFLLIAASFMTLLFCVKVKPNVAVLSRSDPSLVLAFLLCFAISTISF
Sbjct: 301 SWLHWSAWFLLFFLFLLIAASFMTLLFCVKVKPNVAVLSRSDPSLVLAFLLCFAISTISF 360
Query: 361 SFMVSTFFSKANMAAAFGGFLYFFTYIPYFFVAPRYNWMTLSQKLCSCLLSNVAMAMGAQ 420
SFMVSTFFSKANMAAAFGGFLYFFTYIPYFFVAPRYNWMTLSQKLCSCLLSNVAMAMGAQ
Sbjct: 361 SFMVSTFFSKANMAAAFGGFLYFFTYIPYFFVAPRYNWMTLSQKLCSCLLSNVAMAMGAQ 420
Query: 421 LIGKFEAKGMGIQWRDLLSPVNVDDDFCFGQVLGMLLLDSVLYGLVTWYMEAVFPGQFGV 480
LIGKFEAKGMGIQWRDLLSPVNVDDDFCFGQVLGMLLLDSVLYGLVTWYMEAVFPGQFGV
Sbjct: 421 LIGKFEAKGMGIQWRDLLSPVNVDDDFCFGQVLGMLLLDSVLYGLVTWYMEAVFPGQFGV 480
Query: 481 PQPWYFFIMPSYWCGKPRAVAGKEEEDSDPEKALRNEYFEAEPEDLVAGIKIKHLSKVFR 540
PQPWYFFIMPSYWCGKPRAVAGKEEEDSDPEKALRNEYFEAEPEDLVAGIKIKHLSKVFR
Sbjct: 481 PQPWYFFIMPSYWCGKPRAVAGKEEEDSDPEKALRNEYFEAEPEDLVAGIKIKHLSKVFR 540
Query: 541 VGNKDRAAVRDLNLNLYEGQITVLLGHNGAGKTTTLSMLTGLFPPTSGRAYISGYEISQD 600
VGNKDRAAVRDLNLNLYEGQITVLLGHNGAGKTTTLSMLTGLFPPTSGRAYISGYEISQD
Sbjct: 541 VGNKDRAAVRDLNLNLYEGQITVLLGHNGAGKTTTLSMLTGLFPPTSGRAYISGYEISQD 600
Query: 601 MVQIRKSLGLCPQHDILFDNLTVAEHLYFYAQLKGLSRQKCPEEVKQMLHIIGLEDKWNS 660
MVQIRKSLGLCPQHDILFDNLTVAEHLYFYAQLKGLSRQKCPEEVKQMLHIIGLEDKWNS
Sbjct: 601 MVQIRKSLGLCPQHDILFDNLTVAEHLYFYAQLKGLSRQKCPEEVKQMLHIIGLEDKWNS 660
Query: 661 RSRFLSGGMRRKLSIGIALIAGSKVLILDEPTSGMDAISRRAIWDLLQRQKSDRTIVLTT 720
RSRFLSGGMRRKLSIGIALIAGSKVLILDEPTSGMDAISRRAIWDLLQRQKSDRTIVLTT
Sbjct: 661 RSRFLSGGMRRKLSIGIALIAGSKVLILDEPTSGMDAISRRAIWDLLQRQKSDRTIVLTT 720
Query: 721 HFMDEADLLGDRIAIMAKGELQCCGSSLFLKQKYGAGYHMTLVKEPHCNPEDISQLVHHH 780
HFMDEADLLGDRIAIMAKGELQCCGSSLFLKQKYGAGYHMTLVKEPHCNPEDISQLVHHH
Sbjct: 721 HFMDEADLLGDRIAIMAKGELQCCGSSLFLKQKYGAGYHMTLVKEPHCNPEDISQLVHHH 780
Query: 781 VPNATLESSAGAELSFILPRESTHRFEGLFAKLEKKQKELGIASFGASITTMEEVFLRVG 840
VPNATLESSAGAELSFILPRESTHRFEGLFAKLEKKQKELGIASFGASITTMEEVFLRVG
Sbjct: 781 VPNATLESSAGAELSFILPRESTHRFEGLFAKLEKKQKELGIASFGASITTMEEVFLRVG 840
Query: 841 KLVDSSMDIQAIQLPALQYQHERRASDWAVDSNLCGAMDPSDGIGALIEEERTAVKLNTG 900
KLVDSSMDIQAIQLPALQYQHERRASDWAVDSNLCGAMDPSDGIGALIEEERTAVKLNTG
Sbjct: 841 KLVDSSMDIQAIQLPALQYQHERRASDWAVDSNLCGAMDPSDGIGALIEEERTAVKLNTG 900
Query: 901 LALHCQQFWAMFLKKAAYSWREWKMVAAQVLVPLTCVTLALLAINYSSELFDDPMLRLTL 960
LALHCQQFWAMFLKKAAYSWREWKMVAAQVLVPLTCVTLALLAINYSSELFDDPMLRLTL
Sbjct: 901 LALHCQQFWAMFLKKAAYSWREWKMVAAQVLVPLTCVTLALLAINYSSELFDDPMLRLTL 960
Query: 961 GEYGRTVVPFSVPGTSQLGQQLSEHLKDALQAEGQEPREVLGDLEEFLIFRASVEGGGFN 1020
GEYGRTVVPFSVPGTSQLGQQLSEHLKDALQAEGQEPREVLGDLEEFLIFRASVEGGGFN
Sbjct: 961 GEYGRTVVPFSVPGTSQLGQQLSEHLKDALQAEGQEPREVLGDLEEFLIFRASVEGGGFN 1020
Query: 1021 ERCLVAASFRDVGERTVVNALFNNQAYHSPATALAVVDNLLFKLLCGPHASIVVSNFPQP 1080
ERCLVAASFRDVGERTVVNALFNNQAYHSPATALAVVDNLLFKLLCGPHASIVVSNFPQP
Sbjct: 1021 ERCLVAASFRDVGERTVVNALFNNQAYHSPATALAVVDNLLFKLLCGPHASIVVSNFPQP 1080
Query: 1081 RSALQAAKDQFNEGRKGFDIALNLLFAMAFLASTFSILAVSERAVQAKHVQFVSGVHVAS 1140
RSALQAAKDQFNEGRKGFDIALNLLFAMAFLASTFSILAVSERAVQAKHVQFVSGVHVAS
Sbjct: 1081 RSALQAAKDQFNEGRKGFDIALNLLFAMAFLASTFSILAVSERAVQAKHVQFVSGVHVAS 1140
Query: 1141 FWLSALLWDLISFLIPSLLLLVVFKAFDVRAFTRDGHMADTLLLLLLYGWAIIPLMYLMN 1200
FWLSALLWDLISFLIPSLLLLVVFKAFDVRAFTRDGHMADTLLLLLLYGWAIIPLMYLMN
Sbjct: 1141 FWLSALLWDLISFLIPSLLLLVVFKAFDVRAFTRDGHMADTLLLLLLYGWAIIPLMYLMN 1200
Query: 1201 FFFLGAATAYTRLTIFNILSGIATFLMVTIMRIPAVKLEELSKTLDHVFLVLPNHCLGMA 1260
FFFLGAATAYTRLTIFNILSGIATFLMVTIMRIPAVKLEELSKTLDHVFLVLPNHCLGMA
Sbjct: 1201 FFFLGAATAYTRLTIFNILSGIATFLMVTIMRIPAVKLEELSKTLDHVFLVLPNHCLGMA 1260
Query: 1261 VSSFYENYETRRYCTSSEVAAHYCKKYNIQYQENFYAWSAPGVGRFVASMAASGCAYLIL 1320
VSSFYENYETRRYCTSSEVAAHYCKKYNIQYQENFYAWSAPGVGRFVASMAASGCAYLIL
Sbjct: 1261 VSSFYENYETRRYCTSSEVAAHYCKKYNIQYQENFYAWSAPGVGRFVASMAASGCAYLIL 1320
Query: 1321 LFLIETNLLQRLRGILCALRRRRTLTELYTRMPVLPEDQDVADERTRILAPSPDSLLHTP 1380
LFLIETNLLQRLRGILCALRRRRTLTELYTRMPVLPEDQDVADERTRILAPSPDSLLHTP
Sbjct: 1321 LFLIETNLLQRLRGILCALRRRRTLTELYTRMPVLPEDQDVADERTRILAPSPDSLLHTP 1380
Query: 1381 LIIKELSKVYEQRVPLLAVDRLSLAVQKGECFGLLGFNGAGKTTTFKMLTGEESLTSGDA 1440
LIIKELSKVYEQRVPLLAVDRLSLAVQKGECFGLLGFNGAGKTTTFKMLTGEESLTSGDA
Sbjct: 1381 LIIKELSKVYEQRVPLLAVDRLSLAVQKGECFGLLGFNGAGKTTTFKMLTGEESLTSGDA 1440
Query: 1441 FVGGHRISSDVGKVRQRIGYCPQFDALLDHMTGREMLVMYARLRGIPERHIGACVENTLR 1500
FVGGHRISSDVGKVRQRIGYCPQFDALLDHMTGREMLVMYARLRGIPERHIGACVENTLR
Sbjct: 1441 FVGGHRISSDVGKVRQRIGYCPQFDALLDHMTGREMLVMYARLRGIPERHIGACVENTLR 1500
Query: 1501 GLLLEPHANKLVRTYSGGNKRKLSTGIALIGEPAVIFLDEPSTGMDPVARRLLWDTVARA 1560
GLLLEPHANKLVRTYSGGNKRKLSTGIALIGEPAVIFLDEPSTGMDPVARRLLWDTVARA
Sbjct: 1501 GLLLEPHANKLVRTYSGGNKRKLSTGIALIGEPAVIFLDEPSTGMDPVARRLLWDTVARA 1560
Query: 1561 RESGKAIIITSHSMEECEALCTRLAIMVQGQFKCLGSPQHLKSKFGSGYSLRAKVQSEGQ 1620
RESGKAIIITSHSMEECEALCTRLAIMVQGQFKCLGSPQHLKSKFGSGYSLRAKVQSEGQ
Sbjct: 1561 RESGKAIIITSHSMEECEALCTRLAIMVQGQFKCLGSPQHLKSKFGSGYSLRAKVQSEGQ 1620
Query: 1621 QEALEEFKAFVDLTFPGSVLEDEHQGMVHYHLPGRDLSWAKVFGILEKAKEKYGVDDYSV 1680
QEALEEFKAFVDLTFPGSVLEDEHQGMVHYHLPGRDLSWAKVFGILEKAKEKYGVDDYSV
Sbjct: 1621 QEALEEFKAFVDLTFPGSVLEDEHQGMVHYHLPGRDLSWAKVFGILEKAKEKYGVDDYSV 1680
Query: 1681 SQISLEQVFLSFAHLQPPTAEEGR 1704
SQISLEQVFLSFAHLQPPTAEEGR
Sbjct: 1681 SQISLEQVFLSFAHLQPPTAEEGR 1704
>gi|21536376 ATP-binding cassette, sub-family A member 1 [Homo
sapiens]
Length = 2261
Score = 538 bits (1385), Expect = e-152
Identities = 327/821 (39%), Positives = 471/821 (57%), Gaps = 100/821 (12%)
Query: 190 NPGPREPTSPDGGEPGYIREGFLAVQHAVDRAIMEYHADAATRQLFQRLTVTIKRFPYPP 249
+PGPR D Y+ GF +Q V++AI+ ++ V +++ PYP
Sbjct: 575 DPGPRADPFED---MRYVWGGFAYLQDVVEQAIIRVLTGTE-----KKTGVYMQQMPYPC 626
Query: 250 FIADPFLVAIQYQLPLLLLLSFTYTALTIARAVVQEKERRLKEYMRMMGLSSWLHWSAWF 309
++ D FL + +PL + L++ Y+ I + +V EKE RLKE MR+MGL + + W +WF
Sbjct: 627 YVDDIFLRVMSRSMPLFMTLAWIYSVAVIIKGIVYEKEARLKETMRIMGLDNSILWFSWF 686
Query: 310 LLFFLFLLIAASFMTLLFCVKVKPNVAVLSRSDPSLVLAFLLCFAISTISFSFMVSTFFS 369
+ + LL++A + ++ + +L SDPS+V FL FA+ TI F++ST FS
Sbjct: 687 ISSLIPLLVSAGLLVVILKLG-----NLLPYSDPSVVFVFLSVFAVVTILQCFLISTLFS 741
Query: 370 KANMAAAFGGFLYFFTYIPYFFVAPRYNWMTLSQKLCSCLLSNVAMAMGAQLIGKFEAKG 429
+AN+AAA GG +YF Y+PY +++ + K+ + LLS VA G + FE +G
Sbjct: 742 RANLAAACGGIIYFTLYLPYVLCVAWQDYVGFTLKIFASLLSPVAFGFGCEYFALFEEQG 801
Query: 430 MGIQWRDLLSPVNVDDDFCFGQVLGMLLLDSVLYGLVTWYMEAVFPGQFGVPQPWYFFIM 489
+G+QW +L +D F + M+L D+ LYG++TWY+EAVFPGQ+G+P+PWYF
Sbjct: 802 IGVQWDNLFESPVEEDGFNLTTSVSMMLFDTFLYGVMTWYIEAVFPGQYGIPRPWYFPCT 861
Query: 490 PSYWCGKPRAVAGKEEEDSDP---EKALRNEYFEAEPEDLVAGIKIKHLSKVFRVGNKDR 546
SYW G+ + +E S P +K + E EP L G+ I++L KV+R G K
Sbjct: 862 KSYWFGE------ESDEKSHPGSNQKRISEICMEEEPTHLKLGVSIQNLVKVYRDGMK-- 913
Query: 547 AAVRDLNLNLYEGQITVLLGHNGAGKTTTLSMLTGLFPPTSGRAYISGYEISQDMVQIRK 606
AV L LN YEGQIT LGHNGAGKTTT+S+LTGLFPPTSG AYI G +I +M IR+
Sbjct: 914 VAVDGLALNFYEGQITSFLGHNGAGKTTTMSILTGLFPPTSGTAYILGKDIRSEMSTIRQ 973
Query: 607 SLGLCPQHDILFDNLTVAEHLYFYAQLKGLSRQKCPEEVKQMLHIIGL-EDKWNSRSRFL 665
+LG+CPQH++LFD LTV EH++FYA+LKGLS + E++QM +GL K S++ L
Sbjct: 974 NLGVCPQHNVLFDMLTVEEHIWFYARLKGLSEKHVKAEMEQMALDVGLPSSKLKSKTSQL 1033
Query: 666 SGGMRRKLSIGIALIAGSKVLILDEPTSGMDAISRRAIWDLLQRQKSDRTIVLTTHFMDE 725
SGGM+RKLS+ +A + GSKV+ILDEPT+G+D SRR IW+LL + + RTI+L+TH MDE
Sbjct: 1034 SGGMQRKLSVALAFVGGSKVVILDEPTAGVDPYSRRGIWELLLKYRQGRTIILSTHHMDE 1093
Query: 726 ADLLGDRIAIMAKGELQCCGSSLFLKQKYGAGYHMTLVKE----------------PHCN 769
AD+LGDRIAI++ G+L C GSSLFLK + G GY++TLVK+ +
Sbjct: 1094 ADVLGDRIAIISHGKLCCVGSSLFLKNQLGTGYYLTLVKKDVESSLSSCRNSSSTVSYLK 1153
Query: 770 PED--------------------------ISQLVHHHVPNATLESSAGAELSFILPREST 803
ED IS L+ HV A L G EL+++LP E+
Sbjct: 1154 KEDSVSQSSSDAGLGSDHESDTLTIDVSAISNLIRKHVSEARLVEDIGHELTYVLPYEAA 1213
Query: 804 HR--FEGLFAKLEKKQKELGIASFGASITTMEEVFLRVGKLVDSSMDIQAIQ--LPALQY 859
F LF +++ + +LGI+S+G S TT+EE+FL+V + +S +D + LPA
Sbjct: 1214 KEGAFVELFHEIDDRLSDLGISSYGISETTLEEIFLKVAE--ESGVDAETSDGTLPA--- 1268
Query: 860 QHERRASDWAVDSNLC-------GAMDPSDGIGALIEEERTAVKLNTGL----------- 901
+ RRA D C A DP+D + I+ E L +G+
Sbjct: 1269 RRNRRAFG---DKQSCLRPFTEDDAADPND---SDIDPESRETDLLSGMDGKGSYQVKGW 1322
Query: 902 ALHCQQFWAMFLKKAAYSWREWKMVAAQVLVPLTCVTLALL 942
L QQF A+ K+ + R K AQ+++P V +AL+
Sbjct: 1323 KLTQQQFVALLWKRLLIARRSRKGFFAQIVLPAVFVCIALV 1363
Score = 468 bits (1205), Expect = e-131
Identities = 260/663 (39%), Positives = 399/663 (60%), Gaps = 38/663 (5%)
Query: 1038 VNALFNNQAYHSPATALAVVDNLLFK--LLCGP---HASIVVSNFPQPRSALQAAKDQFN 1092
V FNN+ +H+ ++ L V++N + + L G H I N P + Q ++
Sbjct: 1590 VKVWFNNKGWHAISSFLNVINNAILRANLQKGENPSHYGITAFNHPLNLTKQQLSEVALM 1649
Query: 1093 EGRKGFDIALNLLFAMAFLASTFSILAVSERAVQAKHVQFVSGVHVASFWLSALLWDLIS 1152
+++ ++FAM+F+ ++F + + ER +AKH+QF+SGV +WLS +WD+ +
Sbjct: 1650 TTSVDVLVSICVIFAMSFVPASFVVFLIQERVSKAKHLQFISGVKPVIYWLSNFVWDMCN 1709
Query: 1153 FLIPSLLLLVVFKAFDVRAFTRDGHMADTLLLLLLYGWAIIPLMYLMNFFFLGAATAYTR 1212
+++P+ L++++F F +++ ++ LLLLLYGW+I PLMY +F F +TAY
Sbjct: 1710 YVVPATLVIIIFICFQQKSYVSSTNLPVLALLLLLYGWSITPLMYPASFVFKIPSTAYVV 1769
Query: 1213 LTIFNILSGIATFLMVTIMRI-PAVKLEELSKTLDHVFLVLPNHCLGMAVSSFYENYETR 1271
LT N+ GI + ++ + KL ++ L VFL+ P+ CLG + +N
Sbjct: 1770 LTSVNLFIGINGSVATFVLELFTDNKLNNINDILKSVFLIFPHFCLGRGLIDMVKN---- 1825
Query: 1272 RYCTSSEVAAHYCKKYNIQYQENFYAWSAPGVGRFVASMAASGCAYLILLFLIETNLLQR 1331
+ A +++ + +W VGR + +MA G + ++ LI+ R
Sbjct: 1826 ------QAMADALERFGENRFVSPLSWDL--VGRNLFAMAVEGVVFFLITVLIQYRFFIR 1877
Query: 1332 LRGILCALRRRRTLTELYTRMPVLPEDQDVADERTRILAPSPDSLLHTPLIIKELSKVYE 1391
R + L P+ ED+DV ER RIL + + L IKEL+K+Y
Sbjct: 1878 PRPVNAKLS------------PLNDEDEDVRRERQRILDGGGQNDI---LEIKELTKIYR 1922
Query: 1392 Q-RVPLLAVDRLSLAVQKGECFGLLGFNGAGKTTTFKMLTGEESLTSGDAFVGGHRISSD 1450
+ R P AVDR+ + + GECFGLLG NGAGK++TFKMLTG+ ++T GDAF+ + I S+
Sbjct: 1923 RKRKP--AVDRICVGIPPGECFGLLGVNGAGKSSTFKMLTGDTTVTRGDAFLNKNSILSN 1980
Query: 1451 VGKVRQRIGYCPQFDALLDHMTGREMLVMYARLRGIPERHIGACVENTLRGLLLEPHANK 1510
+ +V Q +GYCPQFDA+ + +TGRE + +A LRG+PE+ +G E +R L L + K
Sbjct: 1981 IHEVHQNMGYCPQFDAITELLTGREHVEFFALLRGVPEKEVGKVGEWAIRKLGLVKYGEK 2040
Query: 1511 LVRTYSGGNKRKLSTGIALIGEPAVIFLDEPSTGMDPVARRLLWDTVARARESGKAIIIT 1570
YSGGNKRKLST +ALIG P V+FLDEP+TGMDP ARR LW+ + G+++++T
Sbjct: 2041 YAGNYSGGNKRKLSTAMALIGGPPVVFLDEPTTGMDPKARRFLWNCALSVVKEGRSVVLT 2100
Query: 1571 SHSMEECEALCTRLAIMVQGQFKCLGSPQHLKSKFGSGYSLRAKVQSEGQQEALEEFKAF 1630
SHSMEECEALCTR+AIMV G+F+CLGS QHLK++FG GY++ ++ G L+ + F
Sbjct: 2101 SHSMEECEALCTRMAIMVNGRFRCLGSVQHLKNRFGDGYTIVVRI--AGSNPDLKPVQDF 2158
Query: 1631 VDLTFPGSVLEDEHQGMVHYHLPGRDLSWAKVFGILEKAKEKYGVDDYSVSQISLEQVFL 1690
L FPGSVL+++H+ M+ Y LP S A++F IL ++K++ ++DYSVSQ +L+QVF+
Sbjct: 2159 FGLAFPGSVLKEKHRNMLQYQLPSSLSSLARIFSILSQSKKRLHIEDYSVSQTTLDQVFV 2218
Query: 1691 SFA 1693
+FA
Sbjct: 2219 NFA 2221
Score = 182 bits (461), Expect = 3e-45
Identities = 159/606 (26%), Positives = 291/606 (48%), Gaps = 57/606 (9%)
Query: 258 AIQYQLPLLLLLSFTYTALTIARAVVQEKERRLKEYMRMMGLSSWLHWSAWFLLFFLFLL 317
++ + + ++ + ++ + ++QE+ + K + G+ ++W + F+ +
Sbjct: 1652 SVDVLVSICVIFAMSFVPASFVVFLIQERVSKAKHLQFISGVKPVIYWLSNFVWDMCNYV 1711
Query: 318 IAASFMTLLF-CVKVKPNVAVLSRSDPSLVLAFLLC-FAISTI----SFSFMVST----F 367
+ A+ + ++F C + K V+ S + P L L LL ++I+ + SF F + +
Sbjct: 1712 VPATLVIIIFICFQQKSYVS--STNLPVLALLLLLYGWSITPLMYPASFVFKIPSTAYVV 1769
Query: 368 FSKANMAAAFGGFLYFFTYIPYFFVAPRYNWMTLSQKLCSCLLSNVAMAMGAQLIGKFEA 427
+ N+ G + T++ F + N ++ L S L +G LI +
Sbjct: 1770 LTSVNLFIGINGSVA--TFVLELFTDNKLN--NINDILKSVFLIFPHFCLGRGLIDMVKN 1825
Query: 428 KGMG-----IQWRDLLSPVNVDDDFCFGQVLGMLLLDSVLYGLVTWYMEAVFPGQFGVPQ 482
+ M +SP++ D G+ L + ++ V++ L+T ++
Sbjct: 1826 QAMADALERFGENRFVSPLSWD---LVGRNLFAMAVEGVVFFLITVLIQ----------- 1871
Query: 483 PWYFFIMPSYWCGKPRAVAGK----EEEDSDPEKALRNEYFEAEPEDLVAGIKIKHLSKV 538
+ FFI +PR V K +ED D + + D+ ++IK L+K+
Sbjct: 1872 -YRFFI-------RPRPVNAKLSPLNDEDEDVRRERQRILDGGGQNDI---LEIKELTKI 1920
Query: 539 FRVGNKDRAAVRDLNLNLYEGQITVLLGHNGAGKTTTLSMLTGLFPPTSGRAYISGYEIS 598
+R K + AV + + + G+ LLG NGAGK++T MLTG T G A+++ I
Sbjct: 1921 YR--RKRKPAVDRICVGIPPGECFGLLGVNGAGKSSTFKMLTGDTTVTRGDAFLNKNSIL 1978
Query: 599 QDMVQIRKSLGLCPQHDILFDNLTVAEHLYFYAQLKGLSRQKCPEEVKQMLHIIGLEDKW 658
++ ++ +++G CPQ D + + LT EH+ F+A L+G+ ++ + + + +GL
Sbjct: 1979 SNIHEVHQNMGYCPQFDAITELLTGREHVEFFALLRGVPEKEVGKVGEWAIRKLGLVKYG 2038
Query: 659 NSRSRFLSGGMRRKLSIGIALIAGSKVLILDEPTSGMDAISRRAIWD-LLQRQKSDRTIV 717
+ SGG +RKLS +ALI G V+ LDEPT+GMD +RR +W+ L K R++V
Sbjct: 2039 EKYAGNYSGGNKRKLSTAMALIGGPPVVFLDEPTTGMDPKARRFLWNCALSVVKEGRSVV 2098
Query: 718 LTTHFMDEADLLGDRIAIMAKGELQCCGSSLFLKQKYGAGYHMTLVKEPHCNPE--DISQ 775
LT+H M+E + L R+AIM G +C GS LK ++G GY + +V+ NP+ +
Sbjct: 2099 LTSHSMEECEALCTRMAIMVNGRFRCLGSVQHLKNRFGDGYTI-VVRIAGSNPDLKPVQD 2157
Query: 776 LVHHHVPNATLESSAGAELSFILPRESTHRFEGLFAKLEKKQKELGIASFGASITTMEEV 835
P + L+ L + LP S +F+ L + +K L I + S TT+++V
Sbjct: 2158 FFGLAFPGSVLKEKHRNMLQYQLP-SSLSSLARIFSILSQSKKRLHIEDYSVSQTTLDQV 2216
Query: 836 FLRVGK 841
F+ K
Sbjct: 2217 FVNFAK 2222
Score = 167 bits (423), Expect = 8e-41
Identities = 94/231 (40%), Positives = 143/231 (61%), Gaps = 5/231 (2%)
Query: 1383 IKELSKVYEQRVPLLAVDRLSLAVQKGECFGLLGFNGAGKTTTFKMLTGEESLTSGDAFV 1442
I+ L KVY + + AVD L+L +G+ LG NGAGKTTT +LTG TSG A++
Sbjct: 901 IQNLVKVYRDGMKV-AVDGLALNFYEGQITSFLGHNGAGKTTTMSILTGLFPPTSGTAYI 959
Query: 1443 GGHRISSDVGKVRQRIGYCPQFDALLDHMTGREMLVMYARLRGIPERHIGACVENTLRGL 1502
G I S++ +RQ +G CPQ + L D +T E + YARL+G+ E+H+ A +E +
Sbjct: 960 LGKDIRSEMSTIRQNLGVCPQHNVLFDMLTVEEHIWFYARLKGLSEKHVKAEMEQMALDV 1019
Query: 1503 LLEPHANKLVRT--YSGGNKRKLSTGIALIGEPAVIFLDEPSTGMDPVARRLLWDTVARA 1560
L P + +T SGG +RKLS +A +G V+ LDEP+ G+DP +RR +W+ + +
Sbjct: 1020 GL-PSSKLKSKTSQLSGGMQRKLSVALAFVGGSKVVILDEPTAGVDPYSRRGIWELLLKY 1078
Query: 1561 RESGKAIIITSHSMEECEALCTRLAIMVQGQFKCLGSPQHLKSKFGSGYSL 1611
R+ G+ II+++H M+E + L R+AI+ G+ C+GS LK++ G+GY L
Sbjct: 1079 RQ-GRTIILSTHHMDEADVLGDRIAIISHGKLCCVGSSLFLKNQLGTGYYL 1128
Score = 37.7 bits (86), Expect = 0.096
Identities = 21/44 (47%), Positives = 27/44 (61%)
Query: 1 MAVLRQLALLLWKNYTLQKRKVLVTVLELFLPLLFSGILIWLRL 44
MA QL LLLWKN T ++R+ +LE+ PL ILI +RL
Sbjct: 1 MACWPQLRLLLWKNLTFRRRQTCQLLLEVAWPLFIFLILISVRL 44
>gi|27262624 ATP-binding cassette, sub-family A , member 5 [Homo
sapiens]
Length = 1642
Score = 534 bits (1376), Expect = e-151
Identities = 463/1748 (26%), Positives = 804/1748 (45%), Gaps = 191/1748 (10%)
Query: 1 MAVLRQLALLLWKNYTLQKRKVLVTVLELFLPLLFSGILIWLRLKIQSENVPNATIYPGQ 60
+ V RQ LL KNY ++ R +V E+ PL F L WL L + ++P +
Sbjct: 8 VGVWRQTRTLLLKNYLIKCRTKKSSVQEILFPLFF---LFWLILI--------SMMHPNK 56
Query: 61 SIQELPLFFTFPPPGDTWELAYIPSHSDAAKTVTETVRRALVINMRVRGFPSEKDFEDYI 120
+E+P P D + L+ + +T ++ + + + P E+Y
Sbjct: 57 KYEEVPNIELNPM--DKFTLSNLILGYTPVTNITSSIMQKVSTDH----LPDVIITEEYT 110
Query: 121 RYDNCSSSVLAAVVFEHPFNHSKEPLPLAVKYHLRFSYTRRNYMWTQTGSFFLKETEGWH 180
+S L+ P N ++ Y LRF S ++ G
Sbjct: 111 NEKEMLTSSLSK-----PSNFVGVVFKDSMSYELRFFPDM-----IPVSSIYMDSRAG-- 158
Query: 181 TTSLFPLFPNPGPREPTSPDGGEPGYIREGFLAVQHAVDRAIMEYHADAA-------TRQ 233
S Y GF +Q ++D AI++ + + T+
Sbjct: 159 ----------------CSKSCEAAQYWSSGFTVLQASIDAAIIQLKTNVSLWKELESTKA 202
Query: 234 LFQRLTVTIKRFPYPPFIADPFLVAIQYQLPLLLLLSFTYTALTIARAVVQEKERRLKEY 293
+ T ++ +P + + + L+++F+ +A +V EKE+++KE+
Sbjct: 203 VIMGETAVVEIDTFPRGV-----------ILIYLVIAFSPFGYFLAIHIVAEKEKKIKEF 251
Query: 294 MRMMGLSSWLHWSAWFLLFFLFLLIAASFMTLLFCVKVKPNVAVLSRSDPSLVLAFLLCF 353
+++MGL W +W LL+ + + M+LL V ++ S + L F L +
Sbjct: 252 LKIMGLHDTAFWLSWVLLYTSLIFL----MSLLMAVIATASLLFPQSSSIVIFLLFFL-Y 306
Query: 354 AISTISFSFMVSTFFSKANMAAAFGGFLYFFTYIPYFFVAPRYNWMTLSQKLCSCLLS-- 411
+S++ F+ M++ F K+ G + FF + + F+ + K L S
Sbjct: 307 GLSSVFFALMLTPLFKKSKHV----GIVEFFVTVAFGFIGLMIILIESFPKSLVWLFSPF 362
Query: 412 -NVAMAMGAQLIGKFEAKGMGIQWRDLLSPVNVDDDFCFGQVLGMLLLDSVLYGLVTWYM 470
+ +G + E G + +L + + + ML L+S+ Y L+ Y+
Sbjct: 363 CHCTFVIGIAQVMHLEDFNEGASFSNLTA-----GPYPLIITIIMLTLNSIFYVLLAVYL 417
Query: 471 EAVFPGQFGVPQPWYFFIMPSYWCGKPRAVAGKEEEDSDPEKALRNEYFEAEPEDLVA-- 528
+ V PG+FG+ + +F+ PSYW R E + + + +E E + V
Sbjct: 418 DQVIPGEFGLRRSSLYFLKPSYWSKSKRNYEELSEGNVNGNISF-SEIIEPVSSEFVGKE 476
Query: 529 GIKIKHLSKVFRVGNKDRAAVRDLNLNLYEGQITVLLGHNGAGKTTTLSMLTGLFPPTSG 588
I+I + K +R ++ A+R+L+ ++YEGQIT LLGH+G GK+T +++L GL PP+ G
Sbjct: 477 AIRISGIQKTYRKKGENVEALRNLSFDIYEGQITALLGHSGTGKSTLMNILCGLCPPSDG 536
Query: 589 RAYISGYEISQ--DMVQIRKSLGLCPQHDILFDNLTVAEHLYFYAQLKGLSRQKCPEEVK 646
A I G+ +S+ +M + RK +G+CPQ DI FD LTV E+L A +KG+ +EV+
Sbjct: 537 FASIYGHRVSEIDEMFEARKMIGICPQLDIHFDVLTVEENLSILASIKGIPANNIIQEVQ 596
Query: 647 QMLHIIGLEDKWNSRSRFLSGGMRRKLSIGIALIAGSKVLILDEPTSGMDAISRRAIWDL 706
++L + ++ +++++ LSGG +RKLS+GIA++ K+L+LDEPT+GMD SR +W+L
Sbjct: 597 KVLLDLDMQTIKDNQAKKLSGGQKRKLSLGIAVLGNPKILLLDEPTAGMDPCSRHIVWNL 656
Query: 707 LQRQKSDRTIVLTTHFMDEADLLGDRIAIMAKGELQCCGSSLFLKQKYGAGYHMTLVKEP 766
L+ +K++R V +THFMDEAD+L DR A++++G L+C GSS+FLK K+G GY +++ +
Sbjct: 657 LKYRKANRVTVFSTHFMDEADILADRKAVISQGMLKCVGSSMFLKSKWGIGYRLSMYIDK 716
Query: 767 HCNPEDISQLVHHHVPNATLESSAGAELSFILPRESTHRFEGLFAKLEKKQKELGIASFG 826
+C E +S LV H+P ATL +L + LP + +F GLF+ L+ LG+ S+G
Sbjct: 717 YCATESLSSLVKQHIPGATLLQQNDQQLVYSLPFKDMDKFSGLFSALD-SHSNLGVISYG 775
Query: 827 ASITTMEEVFLRVGKLVDSSMDIQAIQLPALQYQHERRASDWAVDSNLCGAMDPSDGIGA 886
S+TT+E+VFL++ V++ +D + Q E +DS M+ S
Sbjct: 776 VSMTTLEDVFLKLE--VEAEIDQADYSVFTQQPLEEE------MDSKSFDEMEQS----L 823
Query: 887 LIEEERTAVKLNTGLALHCQQFWAMFLKKAAYSWREWKMVAAQVLVPLTCVTLALLAINY 946
LI E A ++T ++L QQ + + RE K V + L LL I +
Sbjct: 824 LILSETKAALVST-MSLWKQQMYTIAKFHFFTLKRESKSVRS---------VLLLLLIFF 873
Query: 947 SSELFDDPMLRLTLGEYGRTVVP--------FSVPGTSQLGQQLSEHLKDALQAEGQEPR 998
+ ++F + L + VVP F PG + S L+++ ++
Sbjct: 874 TVQIF----MFLVHHSFKNAVVPIKLVPDLYFLKPGDKPHKYKTSLLLQNSADSD----- 924
Query: 999 EVLGDLEEFL----IFRASVEGGGFNERCLVAASFRDVGERT--VVNALFNNQAYHSPAT 1052
+ DL F I + + +A+ + V A+FN+ +S
Sbjct: 925 --ISDLISFFTSQNIMVTMINDSDYVSVAPHSAALNVMHSEKDYVFAAVFNSTMVYSLPI 982
Query: 1053 ALAVVDNLLFKLLCGPHASIVVSNFPQPRSALQAAKDQFNEGRKGFDIALNLLFAMAFLA 1112
+ ++ N H ++ + Q D + F AL L + +
Sbjct: 983 LVNIISNYYLY-----HLNVTETIQIWSTPFFQEITDIVFKIELYFQAAL-LGIIVTAMP 1036
Query: 1113 STFSILAVSERAVQAKHVQFVSGVHVASFWLSALLWDLISFLIPSLLLLVVFKAFDVRAF 1172
F++ ++A +SG+ +++W+ + D+ F I +L+L AF +
Sbjct: 1037 PYFAMENAENHKIKAYTQLKLSGLLPSAYWIGQAVVDIPLFFIILILMLGSLLAFHYGLY 1096
Query: 1173 TRDGHMADTLLLLLLYGWAIIPLMYLMNFFFLGAATAYTRLTIFNILSGIATFLMVTIMR 1232
+ L+ Y ++I Y+ +F F ++ + +A + I
Sbjct: 1097 FYTVKFLAVVFCLIGYVPSVILFTYIASFTF---KKILNTKEFWSFIYSVAALACIAITE 1153
Query: 1233 IPAVKLEELSKTLDHVF-LVLPNH-CLGMAVSSFYENYETRRYCTSSEVAAHYCKKYNIQ 1290
I ++ L + F +++P + LG +S +++ R +
Sbjct: 1154 ITFFMGYTIATILHYAFCIIIPIYPLLGCLISFIKISWKNVR-----------------K 1196
Query: 1291 YQENFYAWSAPGVGRFVASMAASGCAYLILLFLIETNLLQRLRGILCALRRRRTLTELYT 1350
+ + W V V S ++ LL E R ++R+ L T
Sbjct: 1197 NVDTYNPWDRLSVA--VISPYLQCVLWIFLLQYYEKKYGGR------SIRKDPFFRNLST 1248
Query: 1351 -----RMPVLP----EDQDVADERTRI--LAPSPDSLLHTPLIIKELSKVYE-------- 1391
++P P ED+DV ER ++ L +++ L K Y+
Sbjct: 1249 KSKNRKLPEPPDNEDEDEDVKAERLKVKELMGCQCCEEKPSIMVSNLHKEYDDKKDFLLS 1308
Query: 1392 QRVPLLAVDRLSLAVQKGECFGLLGFNGAGKTTTFKMLTGEESLTSGDAFVGGHRI-SSD 1450
++V +A +S V+KGE GLLG NGAGK+T +L G+ TSG F+G + +S+
Sbjct: 1309 RKVKKVATKYISFCVKKGEILGLLGPNGAGKSTIINILVGDIEPTSGQVFLGDYSSETSE 1368
Query: 1451 VGKVRQRIGYCPQFDALLDHMTGREMLVMYARLRGIPERHIGACVENTLRGLLLEPHANK 1510
+ +GYCPQ + L T +E +Y ++G+ + + L L+ H K
Sbjct: 1369 DDDSLKCMGYCPQINPLWPDTTLQEHFEIYGAVKGMSASDMKEVISRITHALDLKEHLQK 1428
Query: 1511 LVRTYSGGNKRKLSTGIALIGEPAVIFLDEPSTGMDPVARRLLWDTVARARESGK-AIII 1569
V+ G KRKL ++++G P + LDEPSTGMDP A++ +W + A ++ K A I+
Sbjct: 1429 TVKKLPAGIKRKLCFALSMLGNPQITLLDEPSTGMDPKAKQHMWRAIRTAFKNRKRAAIL 1488
Query: 1570 TSHSMEECEALCTRLAIMVQGQFKCLGSPQHLKSKFGSGYSLRAKVQSEGQQEALEEFKA 1629
T+H MEE EA+C R+AIMV GQ +C+G+ QHLKSKFG GY L K++ + ++ +
Sbjct: 1489 TTHYMEEAEAVCDRVAIMVSGQLRCIGTVQHLKSKFGKGYFLEIKLKDWIENLEVDRLQR 1548
Query: 1630 FVDLTFPGSVLEDEHQGMVHYHLPGRDL-SWAKVFGILEKAKEKYGVDDYSVSQISLEQV 1688
+ FP + ++ ++ Y +P D+ S ++ F LE+AK + +++YS SQ +LEQV
Sbjct: 1549 EIQYIFPNASRQESFSSILAYKIPKEDVQSLSQSFFKLEEAKHAFAIEEYSFSQATLEQV 1608
Query: 1689 FLSFAHLQ 1696
F+ Q
Sbjct: 1609 FVELTKEQ 1616
>gi|27262626 ATP-binding cassette, sub-family A , member 5 [Homo
sapiens]
Length = 1642
Score = 534 bits (1376), Expect = e-151
Identities = 463/1748 (26%), Positives = 804/1748 (45%), Gaps = 191/1748 (10%)
Query: 1 MAVLRQLALLLWKNYTLQKRKVLVTVLELFLPLLFSGILIWLRLKIQSENVPNATIYPGQ 60
+ V RQ LL KNY ++ R +V E+ PL F L WL L + ++P +
Sbjct: 8 VGVWRQTRTLLLKNYLIKCRTKKSSVQEILFPLFF---LFWLILI--------SMMHPNK 56
Query: 61 SIQELPLFFTFPPPGDTWELAYIPSHSDAAKTVTETVRRALVINMRVRGFPSEKDFEDYI 120
+E+P P D + L+ + +T ++ + + + P E+Y
Sbjct: 57 KYEEVPNIELNPM--DKFTLSNLILGYTPVTNITSSIMQKVSTDH----LPDVIITEEYT 110
Query: 121 RYDNCSSSVLAAVVFEHPFNHSKEPLPLAVKYHLRFSYTRRNYMWTQTGSFFLKETEGWH 180
+S L+ P N ++ Y LRF S ++ G
Sbjct: 111 NEKEMLTSSLSK-----PSNFVGVVFKDSMSYELRFFPDM-----IPVSSIYMDSRAG-- 158
Query: 181 TTSLFPLFPNPGPREPTSPDGGEPGYIREGFLAVQHAVDRAIMEYHADAA-------TRQ 233
S Y GF +Q ++D AI++ + + T+
Sbjct: 159 ----------------CSKSCEAAQYWSSGFTVLQASIDAAIIQLKTNVSLWKELESTKA 202
Query: 234 LFQRLTVTIKRFPYPPFIADPFLVAIQYQLPLLLLLSFTYTALTIARAVVQEKERRLKEY 293
+ T ++ +P + + + L+++F+ +A +V EKE+++KE+
Sbjct: 203 VIMGETAVVEIDTFPRGV-----------ILIYLVIAFSPFGYFLAIHIVAEKEKKIKEF 251
Query: 294 MRMMGLSSWLHWSAWFLLFFLFLLIAASFMTLLFCVKVKPNVAVLSRSDPSLVLAFLLCF 353
+++MGL W +W LL+ + + M+LL V ++ S + L F L +
Sbjct: 252 LKIMGLHDTAFWLSWVLLYTSLIFL----MSLLMAVIATASLLFPQSSSIVIFLLFFL-Y 306
Query: 354 AISTISFSFMVSTFFSKANMAAAFGGFLYFFTYIPYFFVAPRYNWMTLSQKLCSCLLS-- 411
+S++ F+ M++ F K+ G + FF + + F+ + K L S
Sbjct: 307 GLSSVFFALMLTPLFKKSKHV----GIVEFFVTVAFGFIGLMIILIESFPKSLVWLFSPF 362
Query: 412 -NVAMAMGAQLIGKFEAKGMGIQWRDLLSPVNVDDDFCFGQVLGMLLLDSVLYGLVTWYM 470
+ +G + E G + +L + + + ML L+S+ Y L+ Y+
Sbjct: 363 CHCTFVIGIAQVMHLEDFNEGASFSNLTA-----GPYPLIITIIMLTLNSIFYVLLAVYL 417
Query: 471 EAVFPGQFGVPQPWYFFIMPSYWCGKPRAVAGKEEEDSDPEKALRNEYFEAEPEDLVA-- 528
+ V PG+FG+ + +F+ PSYW R E + + + +E E + V
Sbjct: 418 DQVIPGEFGLRRSSLYFLKPSYWSKSKRNYEELSEGNVNGNISF-SEIIEPVSSEFVGKE 476
Query: 529 GIKIKHLSKVFRVGNKDRAAVRDLNLNLYEGQITVLLGHNGAGKTTTLSMLTGLFPPTSG 588
I+I + K +R ++ A+R+L+ ++YEGQIT LLGH+G GK+T +++L GL PP+ G
Sbjct: 477 AIRISGIQKTYRKKGENVEALRNLSFDIYEGQITALLGHSGTGKSTLMNILCGLCPPSDG 536
Query: 589 RAYISGYEISQ--DMVQIRKSLGLCPQHDILFDNLTVAEHLYFYAQLKGLSRQKCPEEVK 646
A I G+ +S+ +M + RK +G+CPQ DI FD LTV E+L A +KG+ +EV+
Sbjct: 537 FASIYGHRVSEIDEMFEARKMIGICPQLDIHFDVLTVEENLSILASIKGIPANNIIQEVQ 596
Query: 647 QMLHIIGLEDKWNSRSRFLSGGMRRKLSIGIALIAGSKVLILDEPTSGMDAISRRAIWDL 706
++L + ++ +++++ LSGG +RKLS+GIA++ K+L+LDEPT+GMD SR +W+L
Sbjct: 597 KVLLDLDMQTIKDNQAKKLSGGQKRKLSLGIAVLGNPKILLLDEPTAGMDPCSRHIVWNL 656
Query: 707 LQRQKSDRTIVLTTHFMDEADLLGDRIAIMAKGELQCCGSSLFLKQKYGAGYHMTLVKEP 766
L+ +K++R V +THFMDEAD+L DR A++++G L+C GSS+FLK K+G GY +++ +
Sbjct: 657 LKYRKANRVTVFSTHFMDEADILADRKAVISQGMLKCVGSSMFLKSKWGIGYRLSMYIDK 716
Query: 767 HCNPEDISQLVHHHVPNATLESSAGAELSFILPRESTHRFEGLFAKLEKKQKELGIASFG 826
+C E +S LV H+P ATL +L + LP + +F GLF+ L+ LG+ S+G
Sbjct: 717 YCATESLSSLVKQHIPGATLLQQNDQQLVYSLPFKDMDKFSGLFSALD-SHSNLGVISYG 775
Query: 827 ASITTMEEVFLRVGKLVDSSMDIQAIQLPALQYQHERRASDWAVDSNLCGAMDPSDGIGA 886
S+TT+E+VFL++ V++ +D + Q E +DS M+ S
Sbjct: 776 VSMTTLEDVFLKLE--VEAEIDQADYSVFTQQPLEEE------MDSKSFDEMEQS----L 823
Query: 887 LIEEERTAVKLNTGLALHCQQFWAMFLKKAAYSWREWKMVAAQVLVPLTCVTLALLAINY 946
LI E A ++T ++L QQ + + RE K V + L LL I +
Sbjct: 824 LILSETKAALVST-MSLWKQQMYTIAKFHFFTLKRESKSVRS---------VLLLLLIFF 873
Query: 947 SSELFDDPMLRLTLGEYGRTVVP--------FSVPGTSQLGQQLSEHLKDALQAEGQEPR 998
+ ++F + L + VVP F PG + S L+++ ++
Sbjct: 874 TVQIF----MFLVHHSFKNAVVPIKLVPDLYFLKPGDKPHKYKTSLLLQNSADSD----- 924
Query: 999 EVLGDLEEFL----IFRASVEGGGFNERCLVAASFRDVGERT--VVNALFNNQAYHSPAT 1052
+ DL F I + + +A+ + V A+FN+ +S
Sbjct: 925 --ISDLISFFTSQNIMVTMINDSDYVSVAPHSAALNVMHSEKDYVFAAVFNSTMVYSLPI 982
Query: 1053 ALAVVDNLLFKLLCGPHASIVVSNFPQPRSALQAAKDQFNEGRKGFDIALNLLFAMAFLA 1112
+ ++ N H ++ + Q D + F AL L + +
Sbjct: 983 LVNIISNYYLY-----HLNVTETIQIWSTPFFQEITDIVFKIELYFQAAL-LGIIVTAMP 1036
Query: 1113 STFSILAVSERAVQAKHVQFVSGVHVASFWLSALLWDLISFLIPSLLLLVVFKAFDVRAF 1172
F++ ++A +SG+ +++W+ + D+ F I +L+L AF +
Sbjct: 1037 PYFAMENAENHKIKAYTQLKLSGLLPSAYWIGQAVVDIPLFFIILILMLGSLLAFHYGLY 1096
Query: 1173 TRDGHMADTLLLLLLYGWAIIPLMYLMNFFFLGAATAYTRLTIFNILSGIATFLMVTIMR 1232
+ L+ Y ++I Y+ +F F ++ + +A + I
Sbjct: 1097 FYTVKFLAVVFCLIGYVPSVILFTYIASFTF---KKILNTKEFWSFIYSVAALACIAITE 1153
Query: 1233 IPAVKLEELSKTLDHVF-LVLPNH-CLGMAVSSFYENYETRRYCTSSEVAAHYCKKYNIQ 1290
I ++ L + F +++P + LG +S +++ R +
Sbjct: 1154 ITFFMGYTIATILHYAFCIIIPIYPLLGCLISFIKISWKNVR-----------------K 1196
Query: 1291 YQENFYAWSAPGVGRFVASMAASGCAYLILLFLIETNLLQRLRGILCALRRRRTLTELYT 1350
+ + W V V S ++ LL E R ++R+ L T
Sbjct: 1197 NVDTYNPWDRLSVA--VISPYLQCVLWIFLLQYYEKKYGGR------SIRKDPFFRNLST 1248
Query: 1351 -----RMPVLP----EDQDVADERTRI--LAPSPDSLLHTPLIIKELSKVYE-------- 1391
++P P ED+DV ER ++ L +++ L K Y+
Sbjct: 1249 KSKNRKLPEPPDNEDEDEDVKAERLKVKELMGCQCCEEKPSIMVSNLHKEYDDKKDFLLS 1308
Query: 1392 QRVPLLAVDRLSLAVQKGECFGLLGFNGAGKTTTFKMLTGEESLTSGDAFVGGHRI-SSD 1450
++V +A +S V+KGE GLLG NGAGK+T +L G+ TSG F+G + +S+
Sbjct: 1309 RKVKKVATKYISFCVKKGEILGLLGPNGAGKSTIINILVGDIEPTSGQVFLGDYSSETSE 1368
Query: 1451 VGKVRQRIGYCPQFDALLDHMTGREMLVMYARLRGIPERHIGACVENTLRGLLLEPHANK 1510
+ +GYCPQ + L T +E +Y ++G+ + + L L+ H K
Sbjct: 1369 DDDSLKCMGYCPQINPLWPDTTLQEHFEIYGAVKGMSASDMKEVISRITHALDLKEHLQK 1428
Query: 1511 LVRTYSGGNKRKLSTGIALIGEPAVIFLDEPSTGMDPVARRLLWDTVARARESGK-AIII 1569
V+ G KRKL ++++G P + LDEPSTGMDP A++ +W + A ++ K A I+
Sbjct: 1429 TVKKLPAGIKRKLCFALSMLGNPQITLLDEPSTGMDPKAKQHMWRAIRTAFKNRKRAAIL 1488
Query: 1570 TSHSMEECEALCTRLAIMVQGQFKCLGSPQHLKSKFGSGYSLRAKVQSEGQQEALEEFKA 1629
T+H MEE EA+C R+AIMV GQ +C+G+ QHLKSKFG GY L K++ + ++ +
Sbjct: 1489 TTHYMEEAEAVCDRVAIMVSGQLRCIGTVQHLKSKFGKGYFLEIKLKDWIENLEVDRLQR 1548
Query: 1630 FVDLTFPGSVLEDEHQGMVHYHLPGRDL-SWAKVFGILEKAKEKYGVDDYSVSQISLEQV 1688
+ FP + ++ ++ Y +P D+ S ++ F LE+AK + +++YS SQ +LEQV
Sbjct: 1549 EIQYIFPNASRQESFSSILAYKIPKEDVQSLSQSFFKLEEAKHAFAIEEYSFSQATLEQV 1608
Query: 1689 FLSFAHLQ 1696
F+ Q
Sbjct: 1609 FVELTKEQ 1616
>gi|105990541 ATP-binding cassette, sub-family A member 4 [Homo
sapiens]
Length = 2273
Score = 527 bits (1358), Expect = e-149
Identities = 324/840 (38%), Positives = 470/840 (55%), Gaps = 84/840 (10%)
Query: 206 YIREGFLAVQHAVDRAIMEYHADAATRQLFQRLTVTIKRFPYPPFIADPFLVAIQYQLPL 265
YI GF +Q V++ I A + + +++ PYP F+ D F++ + P+
Sbjct: 603 YIWGGFAYLQDMVEQGITRSQVQAEAP-----VGIYLQQMPYPCFVDDSFMIILNRCFPI 657
Query: 266 LLLLSFTYTALTIARAVVQEKERRLKEYMRMMGLSSWLHWSAWFLLFFLFLLIAASFMTL 325
++L++ Y+ +++V EKE RLKE ++ G+S+ + W WFL F + ++ +T+
Sbjct: 658 FMVLAWIYSVSMTVKSIVLEKELRLKETLKNQGVSNAVIWCTWFLDSFSIMSMSIFLLTI 717
Query: 326 LFCVKVKPNVAVLSRSDPSLVLAFLLCFAISTISFSFMVSTFFSKANMAAAFGGFLYFFT 385
+ +L SDP ++ FLL F+ +TI F++STFFSKA++AAA G +YF
Sbjct: 718 FIM-----HGRILHYSDPFILFLFLLAFSTATIMLCFLLSTFFSKASLAAACSGVIYFTL 772
Query: 386 YIPYFFVAPRYNWMTLSQKLCSCLLSNVAMAMGAQLIGKFEAKGMGIQWRDLLSPVNVDD 445
Y+P+ + MT K LLS VA G + + +FE +G+G+QW ++ + D
Sbjct: 773 YLPHILCFAWQDRMTAELKKAVSLLSPVAFGFGTEYLVRFEEQGLGLQWSNIGNSPTEGD 832
Query: 446 DFCFGQVLGMLLLDSVLYGLVTWYMEAVFPGQFGVPQPWYFFIMPSYWCG-------KPR 498
+F F + M+LLD+ +YGL+ WY++ VFPG +G P PWYF + SYW G + R
Sbjct: 833 EFSFLLSMQMMLLDAAVYGLLAWYLDQVFPGDYGTPLPWYFLLQESYWLGGEGCSTREER 892
Query: 499 AVAGKE---EEDSDPE--KALRNEYFEAEPEDLVAGIKIKHLSKVFRVGNKDRAAVRDLN 553
A+ E EE DPE + + + +FE E V G+ +K+L K+F R AV LN
Sbjct: 893 ALEKTEPLTEETEDPEHPEGIHDSFFEREHPGWVPGVCVKNLVKIFEPCG--RPAVDRLN 950
Query: 554 LNLYEGQITVLLGHNGAGKTTTLSMLTGLFPPTSGRAYISGYEISQDMVQIRKSLGLCPQ 613
+ YE QIT LGHNGAGKTTTLS+LTGL PPTSG + G +I + +R+SLG+CPQ
Sbjct: 951 ITFYENQITAFLGHNGAGKTTTLSILTGLLPPTSGTVLVGGRDIETSLDAVRQSLGMCPQ 1010
Query: 614 HDILFDNLTVAEHLYFYAQLKGLSRQKCPEEVKQMLHIIGLEDKWNSRSRFLSGGMRRKL 673
H+ILF +LTVAEH+ FYAQLKG S+++ E++ ML GL K N ++ LSGGM+RKL
Sbjct: 1011 HNILFHHLTVAEHMLFYAQLKGKSQEEAQLEMEAMLEDTGLHHKRNEEAQDLSGGMQRKL 1070
Query: 674 SIGIALIAGSKVLILDEPTSGMDAISRRAIWDLLQRQKSDRTIVLTTHFMDEADLLGDRI 733
S+ IA + +KV+ILDEPTSG+D SRR+IWDLL + +S RTI+++TH MDEADLLGDRI
Sbjct: 1071 SVAIAFVGDAKVVILDEPTSGVDPYSRRSIWDLLLKYRSGRTIIMSTHHMDEADLLGDRI 1130
Query: 734 AIMAKGELQCCGSSLFLKQKYGAGYHMTLVK------------EPHCN------------ 769
AI+A+G L C G+ LFLK +G G ++TLV+ E C+
Sbjct: 1131 AIIAQGRLYCSGTPLFLKNCFGTGLYLTLVRKMKNIQSQRKGSEGTCSCSSKGFSTTCPA 1190
Query: 770 ------PE-----DISQL---VHHHVPNATLESSAGAELSFILPRES-THR-FEGLFAKL 813
PE D+++L V HHVP A L G EL F+LP ++ HR + LF +L
Sbjct: 1191 HVDDLTPEQVLDGDVNELMDVVLHHVPEAKLVECIGQELIFLLPNKNFKHRAYASLFREL 1250
Query: 814 EKKQKELGIASFGASITTMEEVFLRVGKLVDSSMDIQAIQLPALQYQHE----------- 862
E+ +LG++SFG S T +EE+FL+V + DS + Q + E
Sbjct: 1251 EETLADLGLSSFGISDTPLEEIFLKVTEDSDSG----PLFAGGAQQKRENVNPRHPCLGP 1306
Query: 863 -RRASDWAVDSNLC--GAMDPSDGIGALIEEERTAVKLNTGLALHCQQFWAMFLKKAAYS 919
+A DSN+C GA E E +LNTG L Q A+ +K+ ++
Sbjct: 1307 REKAGQTPQDSNVCSPGAPAAHPEGQPPPEPECPGPQLNTGTQLVLQHVQALLVKRFQHT 1366
Query: 920 WREWKMVAAQVLVPLTCVTLALLAINYSSELFDDPMLRLTLGEYGRTVVPFSV--PGTSQ 977
R K AQ+++P T V LAL+ + P L L YG+ FS+ PG+ Q
Sbjct: 1367 IRSHKDFLAQIVLPATFVFLALMLSIVIPPFGEYPALTLHPWIYGQQYTFFSMDEPGSEQ 1426
Score = 434 bits (1115), Expect = e-121
Identities = 247/668 (36%), Positives = 385/668 (57%), Gaps = 39/668 (5%)
Query: 1038 VNALFNNQAYHSPATALAVVDNLLFKLLCGPHASIVVSNFPQPRSALQAAKDQFNE---- 1093
+ FNN+ +H+ + L V N + + S L K+Q +E
Sbjct: 1615 IKVWFNNKGWHALVSFLNVAHNAILRASLPKDRSPEEYGITVISQPLNLTKEQLSEITVL 1674
Query: 1094 -GRKGFDIALNLLFAMAFLASTFSILAVSERAVQAKHVQFVSGVHVASFWLSALLWDLIS 1152
+A+ ++F+M+F+ ++F + + ER ++KH+QF+SGV ++W++ LWD+++
Sbjct: 1675 TTSVDAVVAICVIFSMSFVPASFVLYLIQERVNKSKHLQFISGVSPTTYWVTNFLWDIMN 1734
Query: 1153 FLIPSLLLLVVFKAFDVRAFTRDGHMADTLLLLLLYGWAIIPLMYLMNFFFLGAATAYTR 1212
+ + + L++ +F F +A+T ++ + LLLLYGWA+IP+MY +F F +TAY
Sbjct: 1735 YSVSAGLVVGIFIGFQKKAYTSPENLPALVALLLLYGWAVIPMMYPASFLFDVPSTAYVA 1794
Query: 1213 LTIFNILSGIATFLMVTIMRIPAVK--LEELSKTLDHVFLVLPNHCLGMAVSSFYENYET 1270
L+ N+ GI + + I+ + L + L + +V P+ CLG +
Sbjct: 1795 LSCANLFIGINSSAITFILELFENNRTLLRFNAVLRKLLIVFPHFCLGRGLIDL------ 1848
Query: 1271 RRYCTSSEVAAHYCKKYNIQYQENFYAWSAPGVGRFVASMAASGCAYLILLFLIETNLLQ 1330
S+ ++ ++ N + W +G+ + +M G Y +L L++ +
Sbjct: 1849 ----ALSQAVTDVYARFGEEHSANPFHWDL--IGKNLFAMVVEGVVYFLLTLLVQRHFFL 1902
Query: 1331 RLRGILCALRRRRTLTELYTRMPVLPEDQDVADERTRILAPSPDSLLHTPLIIKELSKVY 1390
+ + E T+ P++ ED DVA+ER RI+ + + L + EL+K+Y
Sbjct: 1903 S-----------QWIAEP-TKEPIVDEDDDVAEERQRIITGGNKTDI---LRLHELTKIY 1947
Query: 1391 EQRVPLLAVDRLSLAVQKGECFGLLGFNGAGKTTTFKMLTGEESLTSGDAFVGGHRISSD 1450
AVDRL + V+ GECFGLLG NGAGKTTTFKMLTG+ ++TSGDA V G I ++
Sbjct: 1948 PG-TSSPAVDRLCVGVRPGECFGLLGVNGAGKTTTFKMLTGDTTVTSGDATVAGKSILTN 2006
Query: 1451 VGKVRQRIGYCPQFDALLDHMTGREMLVMYARLRGIPERHIGACVENTLRGLLLEPHANK 1510
+ +V Q +GYCPQFDA+ + +TGRE L +YARLRG+P I +++ L L +A+
Sbjct: 2007 ISEVHQNMGYCPQFDAIDELLTGREHLYLYARLRGVPAEEIEKVANWSIKSLGLTVYADC 2066
Query: 1511 LVRTYSGGNKRKLSTGIALIGEPAVIFLDEPSTGMDPVARRLLWDTVARARESGKAIIIT 1570
L TYSGGNKRKLST IALIG P ++ LDEP+TGMDP ARR+LW+ + G+A+++T
Sbjct: 2067 LAGTYSGGNKRKLSTAIALIGCPPLVLLDEPTTGMDPQARRMLWNVIVSIIREGRAVVLT 2126
Query: 1571 SHSMEECEALCTRLAIMVQGQFKCLGSPQHLKSKFGSGYSLRAKVQS--EGQQEALEEFK 1628
SHSMEECEALCTRLAIMV+G F+C+G+ QHLKSKFG GY + K++S + L +
Sbjct: 2127 SHSMEECEALCTRLAIMVKGAFRCMGTIQHLKSKFGDGYIVTMKIKSPKDDLLPDLNPVE 2186
Query: 1629 AFVDLTFPGSVLEDEHQGMVHYHLPGRDLSWAKVFGILEKAKEKYGVDDYSVSQISLEQV 1688
F FPGSV + H M+ + + L A++F +L K+ +++YSV+Q +L+QV
Sbjct: 2187 QFFQGNFPGSVQRERHYNMLQFQVSSSSL--ARIFQLLLSHKDSLLIEEYSVTQTTLDQV 2244
Query: 1689 FLSFAHLQ 1696
F++FA Q
Sbjct: 2245 FVNFAKQQ 2252
Score = 179 bits (453), Expect = 3e-44
Identities = 118/346 (34%), Positives = 181/346 (52%), Gaps = 40/346 (11%)
Query: 1383 IKELSKVYEQRVPLLAVDRLSLAVQKGECFGLLGFNGAGKTTTFKMLTGEESLTSGDAFV 1442
+K L K++E AVDRL++ + + LG NGAGKTTT +LTG TSG V
Sbjct: 931 VKNLVKIFEP-CGRPAVDRLNITFYENQITAFLGHNGAGKTTTLSILTGLLPPTSGTVLV 989
Query: 1443 GGHRISSDVGKVRQRIGYCPQFDALLDHMTGREMLVMYARLRGIPERHIGACVENTLRGL 1502
GG I + + VRQ +G CPQ + L H+T E ++ YA+L+G + +E L
Sbjct: 990 GGRDIETSLDAVRQSLGMCPQHNILFHHLTVAEHMLFYAQLKGKSQEEAQLEMEAMLEDT 1049
Query: 1503 LLEPHANKLVRTYSGGNKRKLSTGIALIGEPAVIFLDEPSTGMDPVARRLLWDTVARARE 1562
L N+ + SGG +RKLS IA +G+ V+ LDEP++G+DP +RR +WD + + R
Sbjct: 1050 GLHHKRNEEAQDLSGGMQRKLSVAIAFVGDAKVVILDEPTSGVDPYSRRSIWDLLLKYR- 1108
Query: 1563 SGKAIIITSHSMEECEALCTRLAIMVQGQFKCLGSPQHLKSKFGSGYSL---RAKVQSEG 1619
SG+ II+++H M+E + L R+AI+ QG+ C G+P LK+ FG+G L R +
Sbjct: 1109 SGRTIIMSTHHMDEADLLGDRIAIIAQGRLYCSGTPLFLKNCFGTGLYLTLVRKMKNIQS 1168
Query: 1620 QQEALE------------EFKAFVDLTFPGSVLE---DEHQGMVHYHLP--------GRD 1656
Q++ E A VD P VL+ +E +V +H+P G++
Sbjct: 1169 QRKGSEGTCSCSSKGFSTTCPAHVDDLTPEQVLDGDVNELMDVVLHHVPEAKLVECIGQE 1228
Query: 1657 L------------SWAKVFGILEKAKEKYGVDDYSVSQISLEQVFL 1690
L ++A +F LE+ G+ + +S LE++FL
Sbjct: 1229 LIFLLPNKNFKHRAYASLFRELEETLADLGLSSFGISDTPLEEIFL 1274
Score = 175 bits (443), Expect = 4e-43
Identities = 164/612 (26%), Positives = 282/612 (46%), Gaps = 64/612 (10%)
Query: 265 LLLLLSFTYTALTIARAVVQEKERRLKEYMRMMGLSSWLHWSAWFLLFFLFLLIAASFMT 324
+ ++ S ++ + ++QE+ + K + G+S +W FL + ++A +
Sbjct: 1684 ICVIFSMSFVPASFVLYLIQERVNKSKHLQFISGVSPTTYWVTNFLWDIMNYSVSAGLVV 1743
Query: 325 LLFCVKVKPNVAVLSRSDPSLVLAFLLCFAISTI------SFSFMV-STFFSKANMAAAF 377
+F K A S + ++A LL + + I SF F V ST + + A F
Sbjct: 1744 GIFIGFQKK--AYTSPENLPALVALLLLYGWAVIPMMYPASFLFDVPSTAYVALSCANLF 1801
Query: 378 GGF-LYFFTYIPYFFVAPRYNWMTLSQKLCSCLLSNVAMAMGAQLIGKFEAKGMGIQWRD 436
G T+I F R + + L L+ +G LI ++ + +
Sbjct: 1802 IGINSSAITFILELFENNR-TLLRFNAVLRKLLIVFPHFCLGRGLIDLALSQAVTDVYAR 1860
Query: 437 L-----LSPVNVDDDFCFGQVLGMLLLDSVLYGLVTWYMEAVFPGQFGVPQPWYFFIMPS 491
+P + D G+ L ++++ V+Y L+T ++ +FF+ S
Sbjct: 1861 FGEEHSANPFHWD---LIGKNLFAMVVEGVVYFLLTLLVQR------------HFFL--S 1903
Query: 492 YWCGKPRAVAGKEEEDSDPEKALRNEYFEAEPEDLVAG------IKIKHLSKVFRVGNKD 545
W +P +E+D E+ R ++ G +++ L+K++
Sbjct: 1904 QWIAEPTKEPIVDEDDDVAEERQR----------IITGGNKTDILRLHELTKIYP--GTS 1951
Query: 546 RAAVRDLNLNLYEGQITVLLGHNGAGKTTTLSMLTGLFPPTSGRAYISGYEISQDMVQIR 605
AV L + + G+ LLG NGAGKTTT MLTG TSG A ++G I ++ ++
Sbjct: 1952 SPAVDRLCVGVRPGECFGLLGVNGAGKTTTFKMLTGDTTVTSGDATVAGKSILTNISEVH 2011
Query: 606 KSLGLCPQHDILFDNLTVAEHLYFYAQLKGLSRQKCPEEVKQMLHIIGLEDKWNSRSRFL 665
+++G CPQ D + + LT EHLY YA+L+G+ ++ + + +GL + +
Sbjct: 2012 QNMGYCPQFDAIDELLTGREHLYLYARLRGVPAEEIEKVANWSIKSLGLTVYADCLAGTY 2071
Query: 666 SGGMRRKLSIGIALIAGSKVLILDEPTSGMDAISRRAIWD-LLQRQKSDRTIVLTTHFMD 724
SGG +RKLS IALI +++LDEPT+GMD +RR +W+ ++ + R +VLT+H M+
Sbjct: 2072 SGGNKRKLSTAIALIGCPPLVLLDEPTTGMDPQARRMLWNVIVSIIREGRAVVLTSHSME 2131
Query: 725 EADLLGDRIAIMAKGELQCCGSSLFLKQKYGAGYHMTL-VKE------PHCNPEDISQLV 777
E + L R+AIM KG +C G+ LK K+G GY +T+ +K P NP + Q
Sbjct: 2132 ECEALCTRLAIMVKGAFRCMGTIQHLKSKFGDGYIVTMKIKSPKDDLLPDLNP--VEQFF 2189
Query: 778 HHHVPNATLESSAGAELSFILPRESTHRFEGLFAKLEKKQKELGIASFGASITTMEEVFL 837
+ P + L F + S R +F L + L I + + TT+++VF+
Sbjct: 2190 QGNFPGSVQRERHYNMLQFQVSSSSLAR---IFQLLLSHKDSLLIEEYSVTQTTLDQVFV 2246
Query: 838 RVGKLVDSSMDI 849
K S D+
Sbjct: 2247 NFAKQQTESHDL 2258
Score = 48.1 bits (113), Expect = 7e-05
Identities = 23/43 (53%), Positives = 31/43 (72%)
Query: 1 MAVLRQLALLLWKNYTLQKRKVLVTVLELFLPLLFSGILIWLR 43
M +RQ+ LLLWKN+TL+KR+ + V+EL PL +LIWLR
Sbjct: 1 MGFVRQIQLLLWKNWTLRKRQKIRFVVELVWPLSLFLVLIWLR 43
>gi|45446740 ATP-binding cassette, sub-family A, member 2 isoform a
[Homo sapiens]
Length = 2436
Score = 526 bits (1356), Expect = e-149
Identities = 346/963 (35%), Positives = 516/963 (53%), Gaps = 143/963 (14%)
Query: 108 RGFPSEKDFEDYIR----YDNCSSSVLAAVVFEHPFNHSKEPLPLAVKYHLRFSYTRRNY 163
+GFP E+ +Y DN + V A+V+F+ + S LP V Y +R
Sbjct: 581 KGFPDEESIVNYTLNQAYQDNVT--VFASVIFQTRKDGS---LPPHVHYKIR-------- 627
Query: 164 MWTQTGSFFLKETEGWHTTSLFPLFPNPGPREPTSPDGGEPGYIREGFLAVQHAVDRAIM 223
Q SF K T + + PGP G Y GF+ +Q ++RAI+
Sbjct: 628 ---QNSSFTEK------TNEIRRAYWRPGPNT------GGRFYFLYGFVWIQDMMERAII 672
Query: 224 EYHA--DAATRQLFQRLTVTIKRFPYPPFIADPFLVAIQYQLPLLLLLSFTYTALTIARA 281
+ D + ++ FPYP + D FL I++ +PL +++S+ Y+ +
Sbjct: 673 DTFVGHDVVEPGSY------VQMFPYPCYTRDDFLFVIEHMMPLCMVISWVYSVAMTIQH 726
Query: 282 VVQEKERRLKEYMRMMGLSSWLHWSAWFLLFFLFLLIAASFMTLLFCVKVKPNVAVLSRS 341
+V EKE RLKE M+ MGL++ +HW AWF+ F+ L I+ + +T + VL S
Sbjct: 727 IVAEKEHRLKEVMKTMGLNNAVHWVAWFITGFVQLSISVTALTAILKYG-----QVLMHS 781
Query: 342 DPSLVLAFLLCFAISTISFSFMVSTFFSKANMAAAFGGFLYFFTYIPYFFVAPR----YN 397
++ FL +A++TI F F+VS +SKA +A+A GG +YF +Y+PY +VA R ++
Sbjct: 782 HVVIIWLFLAVYAVATIMFCFLVSVLYSKAKLASACGGIIYFLSYVPYMYVAIREEVAHD 841
Query: 398 WMTLSQKLCSCLLSNVAMAMGAQLIGKFEAKGMGIQWRDLLSPVNVDDDFCFGQVLGMLL 457
+T +K + L+S A +G++ +E G+GIQW DDF + ML+
Sbjct: 842 KITAFEKCIASLMSTTAFGLGSKYFALYEVAGVGIQWHTFSQSPVEGDDFNLLLAVTMLM 901
Query: 458 LDSVLYGLVTWYMEAVFPGQFGVPQPWYFFIMPSYWCGKPRAVAGK-------------- 503
+D+V+YG++TWY+EAV PG +G+P+PWYF + SYW G R A +
Sbjct: 902 VDAVVYGILTWYIEAVHPGMYGLPRPWYFPLQKSYWLGSGRTEAWEWSWPWARTPRLSVM 961
Query: 504 EEEDSDPEKALRNEY---FEAEPEDLVAGIKIKHLSKVFRVGNKDRAAVRDLNLNLYEGQ 560
EE+ + ++ R E E EP L + + L+KV++ K A+ L+LNLYE Q
Sbjct: 962 EEDQACAMESRRFEETRGMEEEPTHLPLVVCVDKLTKVYKDDKK--LALNKLSLNLYENQ 1019
Query: 561 ITVLLGHNGAGKTTTLSMLTGLFPPTSGRAYISGYEISQDMVQIRKSLGLCPQHDILFDN 620
+ LGHNGAGKTTT+S+LTGLFPPTSG A I G++I +M +IRK+LG+CPQH++LFD
Sbjct: 1020 VVSFLGHNGAGKTTTMSILTGLFPPTSGSATIYGHDIRTEMDEIRKNLGMCPQHNVLFDR 1079
Query: 621 LTVAEHLYFYAQLKGLSRQKCPEEVKQMLHIIGLEDKWNSRSRFLSGGMRRKLSIGIALI 680
LTV EHL+FY++LK +++++ E+ +M+ + L +K +S + LSGGM+RKLS+ IA +
Sbjct: 1080 LTVEEHLWFYSRLKSMAQEEIRREMDKMIEDLELSNKRHSLVQTLSGGMKRKLSVAIAFV 1139
Query: 681 AGSKVLILDEPTSGMDAISRRAIWDLLQRQKSDRTIVLTTHFMDEADLLGDRIAIMAKGE 740
GS+ +ILDEPT+G+D +RRAIWDL+ + K RTI+L+TH MDEADLLGDRIAI++ G+
Sbjct: 1140 GGSRAIILDEPTAGVDPYARRAIWDLILKYKPGRTILLSTHHMDEADLLGDRIAIISHGK 1199
Query: 741 LQCCGSSLFLKQKYGAGYHMTLVKEP----------------------HCNPEDISQLVH 778
L+CCGS LFLK YG GY +TLVK P C+ +SQ +
Sbjct: 1200 LKCCGSPLFLKGTYGDGYRLTLVKRPAEPGGPQEPGLASSPPGRAPLSSCSELQVSQFIR 1259
Query: 779 HHVPNATLESSAGAELSFILPRESTHR--FEGLFAKLEKKQKELGIASFGASITTMEEVF 836
HV + L S ELS+ILP E+ + FE LF LE+ L ++SFG TT+EEVF
Sbjct: 1260 KHVASCLLVSDTSTELSYILPSEAAKKGAFERLFQHLERSLDALHLSSFGLMDTTLEEVF 1319
Query: 837 LRVGK----LVDSSMDIQAIQ---LPALQ--YQHERRASDWAVDSNL------------C 875
L+V + L +S D++ + LP + E A + A S L
Sbjct: 1320 LKVSEEDQSLENSEADVKESRKDVLPGAEGPASGEGHAGNLARCSELTQSQASLQSASSV 1379
Query: 876 GAMDPSDGIG---------------------ALIEEERTAV--------KLNTGLALHCQ 906
G+ +G G +L E E A+ KL+ G L +
Sbjct: 1380 GSARGDEGAGYTDVYGDYRPLFDNPQDPDNVSLQEVEAEALSRVGQGSRKLDGGW-LKVR 1438
Query: 907 QFWAMFLKKAAYSWREWKMVAAQVLVPLTCVTLALLAINYSSELFDDPMLRLTLGEYGRT 966
QF + +K+ + R K + +Q+L+P V +A+ E+ D P L L+ +Y
Sbjct: 1439 QFHGLLVKRFHCARRNSKALFSQILLPAFFVCVAMTVALSVPEIGDLPPLVLSPSQYHNY 1498
Query: 967 VVP 969
P
Sbjct: 1499 TQP 1501
Score = 463 bits (1191), Expect = e-130
Identities = 270/689 (39%), Positives = 401/689 (58%), Gaps = 53/689 (7%)
Query: 1030 RDVGERTVVNALFNNQAYHSPATALAVVDNLLF-----KLLCGPHA-SIVVSNFPQPRSA 1083
R + R +NN+ YHS T L ++N + K P A I V+N P +++
Sbjct: 1720 RKIAVRRAAQVFYNNKGYHSMPTYLNSLNNAILRANLPKSKGNPAAYGITVTNHPMNKTS 1779
Query: 1084 LQAAKDQFNEGRKGFDIALNLLFAMAFLASTFSILAVSERAVQAKHVQFVSGVHVASFWL 1143
+ D +G IA+ ++ AM+F+ ++F + V+E++ +AKH+QFVSG + +WL
Sbjct: 1780 ASLSLDYLLQGTDVV-IAIFIIVAMSFVPASFVVFLVAEKSTKAKHLQFVSGCNPIIYWL 1838
Query: 1144 SALLWDLISFLIPSLLLLVVFKAFDVRAFTRDGHMADTLLLLLLYGWAIIPLMYLMNFFF 1203
+ +WD++++L+P+ +++ FD+ A+T + L L LLYGW+I P+MY +F+F
Sbjct: 1839 ANYVWDMLNYLVPATCCVIILFVFDLPAYTSPTNFPAVLSLFLLYGWSITPIMYPASFWF 1898
Query: 1204 LGAATAYTRLTIFNILSGI----ATFLMVTIMRIPAVKLEELSKTLDHVFLVLPNHCLGM 1259
++AY L + N+ GI ATFL+ +K+ ++ L FL+ PN+ LG
Sbjct: 1899 EVPSSAYVFLIVINLFIGITATVATFLLQLFEHDKDLKV--VNSYLKSCFLIFPNYNLGH 1956
Query: 1260 AVSSFYENYETRRYCTSSEVAAHYCKKYNIQYQENFYAWSAPGVGRFVASMAASGCAYLI 1319
+ N Y Y K ++ + W V R + +MA G +
Sbjct: 1957 GLMEMAYNEYINEY---------YAKIGQFDKMKSPFEWDI--VTRGLVAMAVEGVVGFL 2005
Query: 1320 LLFLIETNLLQRLRGILCALRRRRTLTELYTRMPV----LPEDQDVADERTRILAPSPDS 1375
L + + N L+R + RMPV + +D DVA ER R+L D+
Sbjct: 2006 LTIMCQYNFLRRPQ-----------------RMPVSTKPVEDDVDVASERQRVLRGDADN 2048
Query: 1376 LLHTPLIIKELSKVYEQRV--PLLAVDRLSLAVQKGECFGLLGFNGAGKTTTFKMLTGEE 1433
+ + I+ L+KVY+ R +LAVDRL L V+ GECFGLLG NGAGKT+TFKMLTG+E
Sbjct: 2049 DM---VKIENLTKVYKSRKIGRILAVDRLCLGVRPGECFGLLGVNGAGKTSTFKMLTGDE 2105
Query: 1434 SLTSGDAFVGGHRISSDVGKVRQRIGYCPQFDALLDHMTGREMLVMYARLRGIPERHIGA 1493
S T G+AFV GH + ++ +V+Q +GYCPQ DAL D +T RE L +Y RLRGI +
Sbjct: 2106 STTGGEAFVNGHSVLKELLQVQQSLGYCPQCDALFDELTAREHLQLYTRLRGISWKDEAR 2165
Query: 1494 CVENTLRGLLLEPHANKLVRTYSGGNKRKLSTGIALIGEPAVIFLDEPSTGMDPVARRLL 1553
V+ L L L +A+K TYSGGNKRKLST IALIG PA IFLDEP+TGMDP ARR L
Sbjct: 2166 VVKWALEKLELTKYADKPAGTYSGGNKRKLSTAIALIGYPAFIFLDEPTTGMDPKARRFL 2225
Query: 1554 WDTVARARESGKAIIITSHSMEECEALCTRLAIMVQGQFKCLGSPQHLKSKFGSGYSLRA 1613
W+ + ++G+++++TSHSMEECEALCTRLAIMV G+ +CLGS QHLK++FG GY +
Sbjct: 2226 WNLILDLIKTGRSVVLTSHSMEECEALCTRLAIMVNGRLRCLGSIQHLKNRFGDGYMITV 2285
Query: 1614 KVQSEGQQEALEEFKAFVDLTFPGSVLEDEHQGMVHYHLPGRDLSWAKVFGILEKAKEKY 1673
+ +S +++++ F + FP ++L++ H V Y L +S A+VF +E+
Sbjct: 2286 RTKS---SQSVKDVVRFFNRNFPEAMLKERHHTKVQYQLKSEHISLAQVFSKMEQVSGVL 2342
Query: 1674 GVDDYSVSQISLEQVFLSFAHLQPPTAEE 1702
G++DYSVSQ +L+ VF++FA Q E+
Sbjct: 2343 GIEDYSVSQTTLDNVFVNFAKKQSDNLEQ 2371
Score = 214 bits (545), Expect = 6e-55
Identities = 175/621 (28%), Positives = 296/621 (47%), Gaps = 44/621 (7%)
Query: 253 DPFLVAIQYQLPLLLLLSFTYTALTIARAVVQEKERRLKEYMRMMGLSSWLHWSAWFLLF 312
D L + + ++++ ++ + +V EK + K + G + ++W A ++
Sbjct: 1785 DYLLQGTDVVIAIFIIVAMSFVPASFVVFLVAEKSTKAKHLQFVSGCNPIIYWLANYVWD 1844
Query: 313 FLFLLIAASFMTLLFCVKVKPNVAVLSRSDPSLVLAFLLCFAISTISFSFMVSTFFSKAN 372
L L+ A+ ++ V P A S ++ VL+ L + S + S +F +
Sbjct: 1845 MLNYLVPATCCVIILFVFDLP--AYTSPTNFPAVLSLFLLYGWSITPIMYPASFWFEVPS 1902
Query: 373 MAAAFGGFLYFF--------TYIPYFFVAPRYNWMTLSQ-KLCSCLLSNVAMAMGA---- 419
A F + F T++ F + + S K C + N + G
Sbjct: 1903 SAYVFLIVINLFIGITATVATFLLQLFEHDKDLKVVNSYLKSCFLIFPNYNLGHGLMEMA 1962
Query: 420 --QLIGKFEAKGMGIQWRDLLSPVNVDDDFCFGQVLGMLLLDSVLYGLVTWYMEAVFPGQ 477
+ I ++ AK +G Q+ + SP D V GLV +E V
Sbjct: 1963 YNEYINEYYAK-IG-QFDKMKSPFE---------------WDIVTRGLVAMAVEGVVGFL 2005
Query: 478 FGVPQPWYFFIMPSYWCGKPRAVAGKEEEDSDPEKALRNEYFEAEPEDLVAGIKIKHLSK 537
+ + F P + V + S+ ++ LR + D+V KI++L+K
Sbjct: 2006 LTIMCQYNFLRRPQRMPVSTKPVEDDVDVASERQRVLRGD----ADNDMV---KIENLTK 2058
Query: 538 VFRVGNKDRA-AVRDLNLNLYEGQITVLLGHNGAGKTTTLSMLTGLFPPTSGRAYISGYE 596
V++ R AV L L + G+ LLG NGAGKT+T MLTG T G A+++G+
Sbjct: 2059 VYKSRKIGRILAVDRLCLGVRPGECFGLLGVNGAGKTSTFKMLTGDESTTGGEAFVNGHS 2118
Query: 597 ISQDMVQIRKSLGLCPQHDILFDNLTVAEHLYFYAQLKGLSRQKCPEEVKQMLHIIGLED 656
+ ++++Q+++SLG CPQ D LFD LT EHL Y +L+G+S + VK L + L
Sbjct: 2119 VLKELLQVQQSLGYCPQCDALFDELTAREHLQLYTRLRGISWKDEARVVKWALEKLELTK 2178
Query: 657 KWNSRSRFLSGGMRRKLSIGIALIAGSKVLILDEPTSGMDAISRRAIWDL-LQRQKSDRT 715
+ + SGG +RKLS IALI + LDEPT+GMD +RR +W+L L K+ R+
Sbjct: 2179 YADKPAGTYSGGNKRKLSTAIALIGYPAFIFLDEPTTGMDPKARRFLWNLILDLIKTGRS 2238
Query: 716 IVLTTHFMDEADLLGDRIAIMAKGELQCCGSSLFLKQKYGAGYHMTLVKEPHCNPEDISQ 775
+VLT+H M+E + L R+AIM G L+C GS LK ++G GY +T+ + + +D+ +
Sbjct: 2239 VVLTSHSMEECEALCTRLAIMVNGRLRCLGSIQHLKNRFGDGYMITVRTKSSQSVKDVVR 2298
Query: 776 LVHHHVPNATLESSAGAELSFILPRESTHRFEGLFAKLEKKQKELGIASFGASITTMEEV 835
+ + P A L+ ++ + L E + +F+K+E+ LGI + S TT++ V
Sbjct: 2299 FFNRNFPEAMLKERHHTKVQYQLKSEHISLAQ-VFSKMEQVSGVLGIEDYSVSQTTLDNV 2357
Query: 836 FLRVGKLVDSSMDIQAIQLPA 856
F+ K +++ Q + P+
Sbjct: 2358 FVNFAKKQSDNLEQQETEPPS 2378
Score = 189 bits (479), Expect = 3e-47
Identities = 120/366 (32%), Positives = 193/366 (52%), Gaps = 28/366 (7%)
Query: 1351 RMPVLPEDQDVADERTRI--LAPSPDSLLHTPLII--KELSKVYEQRVPLLAVDRLSLAV 1406
R+ V+ EDQ A E R + H PL++ +L+KVY+ L A+++LSL +
Sbjct: 957 RLSVMEEDQACAMESRRFEETRGMEEEPTHLPLVVCVDKLTKVYKDDKKL-ALNKLSLNL 1015
Query: 1407 QKGECFGLLGFNGAGKTTTFKMLTGEESLTSGDAFVGGHRISSDVGKVRQRIGYCPQFDA 1466
+ + LG NGAGKTTT +LTG TSG A + GH I +++ ++R+ +G CPQ +
Sbjct: 1016 YENQVVSFLGHNGAGKTTTMSILTGLFPPTSGSATIYGHDIRTEMDEIRKNLGMCPQHNV 1075
Query: 1467 LLDHMTGREMLVMYARLRGIPERHIGACVENTLRGLLLEPHANKLVRTYSGGNKRKLSTG 1526
L D +T E L Y+RL+ + + I ++ + L L + LV+T SGG KRKLS
Sbjct: 1076 LFDRLTVEEHLWFYSRLKSMAQEEIRREMDKMIEDLELSNKRHSLVQTLSGGMKRKLSVA 1135
Query: 1527 IALIGEPAVIFLDEPSTGMDPVARRLLWDTVARARESGKAIIITSHSMEECEALCTRLAI 1586
IA +G I LDEP+ G+DP ARR +WD + + + G+ I++++H M+E + L R+AI
Sbjct: 1136 IAFVGGSRAIILDEPTAGVDPYARRAIWDLILKYK-PGRTILLSTHHMDEADLLGDRIAI 1194
Query: 1587 MVQGQFKCLGSPQHLKSKFGSGYSL---RAKVQSEGQQE----------------ALEEF 1627
+ G+ KC GSP LK +G GY L + + G QE + +
Sbjct: 1195 ISHGKLKCCGSPLFLKGTYGDGYRLTLVKRPAEPGGPQEPGLASSPPGRAPLSSCSELQV 1254
Query: 1628 KAFVDLTFPGSVLEDEHQGMVHYHLP---GRDLSWAKVFGILEKAKEKYGVDDYSVSQIS 1684
F+ +L + + Y LP + ++ ++F LE++ + + + + +
Sbjct: 1255 SQFIRKHVASCLLVSDTSTELSYILPSEAAKKGAFERLFQHLERSLDALHLSSFGLMDTT 1314
Query: 1685 LEQVFL 1690
LE+VFL
Sbjct: 1315 LEEVFL 1320
Score = 54.3 bits (129), Expect = 1e-06
Identities = 37/102 (36%), Positives = 52/102 (50%), Gaps = 6/102 (5%)
Query: 1 MAVLRQLALLLWKNYTLQKRKVLVTVLELFLPLLFSGILIWLRLKIQSENVPNATIY--- 57
M L QL LLLWKN TL++R V E+F+PL+ IL+ LR K + +V + Y
Sbjct: 1 MGFLHQLQLLLWKNVTLKRRSPWVLAFEIFIPLVLFFILLGLRQKKPTISVKEVSFYTAA 60
Query: 58 PGQSIQELPLFFTFPPPGDTWELAYIPSHSDAAKTVTETVRR 99
P S LP+ + P G E ++ A TVT+ + R
Sbjct: 61 PLTSAGILPVMQSLCPDGQRDEFGFL---QYANSTVTQLLER 99
>gi|47078218 ATP-binding cassette, sub-family A, member 2 isoform b
[Homo sapiens]
Length = 2466
Score = 526 bits (1356), Expect = e-149
Identities = 346/963 (35%), Positives = 516/963 (53%), Gaps = 143/963 (14%)
Query: 108 RGFPSEKDFEDYIR----YDNCSSSVLAAVVFEHPFNHSKEPLPLAVKYHLRFSYTRRNY 163
+GFP E+ +Y DN + V A+V+F+ + S LP V Y +R
Sbjct: 611 KGFPDEESIVNYTLNQAYQDNVT--VFASVIFQTRKDGS---LPPHVHYKIR-------- 657
Query: 164 MWTQTGSFFLKETEGWHTTSLFPLFPNPGPREPTSPDGGEPGYIREGFLAVQHAVDRAIM 223
Q SF K T + + PGP G Y GF+ +Q ++RAI+
Sbjct: 658 ---QNSSFTEK------TNEIRRAYWRPGPNT------GGRFYFLYGFVWIQDMMERAII 702
Query: 224 EYHA--DAATRQLFQRLTVTIKRFPYPPFIADPFLVAIQYQLPLLLLLSFTYTALTIARA 281
+ D + ++ FPYP + D FL I++ +PL +++S+ Y+ +
Sbjct: 703 DTFVGHDVVEPGSY------VQMFPYPCYTRDDFLFVIEHMMPLCMVISWVYSVAMTIQH 756
Query: 282 VVQEKERRLKEYMRMMGLSSWLHWSAWFLLFFLFLLIAASFMTLLFCVKVKPNVAVLSRS 341
+V EKE RLKE M+ MGL++ +HW AWF+ F+ L I+ + +T + VL S
Sbjct: 757 IVAEKEHRLKEVMKTMGLNNAVHWVAWFITGFVQLSISVTALTAILKYG-----QVLMHS 811
Query: 342 DPSLVLAFLLCFAISTISFSFMVSTFFSKANMAAAFGGFLYFFTYIPYFFVAPR----YN 397
++ FL +A++TI F F+VS +SKA +A+A GG +YF +Y+PY +VA R ++
Sbjct: 812 HVVIIWLFLAVYAVATIMFCFLVSVLYSKAKLASACGGIIYFLSYVPYMYVAIREEVAHD 871
Query: 398 WMTLSQKLCSCLLSNVAMAMGAQLIGKFEAKGMGIQWRDLLSPVNVDDDFCFGQVLGMLL 457
+T +K + L+S A +G++ +E G+GIQW DDF + ML+
Sbjct: 872 KITAFEKCIASLMSTTAFGLGSKYFALYEVAGVGIQWHTFSQSPVEGDDFNLLLAVTMLM 931
Query: 458 LDSVLYGLVTWYMEAVFPGQFGVPQPWYFFIMPSYWCGKPRAVAGK-------------- 503
+D+V+YG++TWY+EAV PG +G+P+PWYF + SYW G R A +
Sbjct: 932 VDAVVYGILTWYIEAVHPGMYGLPRPWYFPLQKSYWLGSGRTEAWEWSWPWARTPRLSVM 991
Query: 504 EEEDSDPEKALRNEY---FEAEPEDLVAGIKIKHLSKVFRVGNKDRAAVRDLNLNLYEGQ 560
EE+ + ++ R E E EP L + + L+KV++ K A+ L+LNLYE Q
Sbjct: 992 EEDQACAMESRRFEETRGMEEEPTHLPLVVCVDKLTKVYKDDKK--LALNKLSLNLYENQ 1049
Query: 561 ITVLLGHNGAGKTTTLSMLTGLFPPTSGRAYISGYEISQDMVQIRKSLGLCPQHDILFDN 620
+ LGHNGAGKTTT+S+LTGLFPPTSG A I G++I +M +IRK+LG+CPQH++LFD
Sbjct: 1050 VVSFLGHNGAGKTTTMSILTGLFPPTSGSATIYGHDIRTEMDEIRKNLGMCPQHNVLFDR 1109
Query: 621 LTVAEHLYFYAQLKGLSRQKCPEEVKQMLHIIGLEDKWNSRSRFLSGGMRRKLSIGIALI 680
LTV EHL+FY++LK +++++ E+ +M+ + L +K +S + LSGGM+RKLS+ IA +
Sbjct: 1110 LTVEEHLWFYSRLKSMAQEEIRREMDKMIEDLELSNKRHSLVQTLSGGMKRKLSVAIAFV 1169
Query: 681 AGSKVLILDEPTSGMDAISRRAIWDLLQRQKSDRTIVLTTHFMDEADLLGDRIAIMAKGE 740
GS+ +ILDEPT+G+D +RRAIWDL+ + K RTI+L+TH MDEADLLGDRIAI++ G+
Sbjct: 1170 GGSRAIILDEPTAGVDPYARRAIWDLILKYKPGRTILLSTHHMDEADLLGDRIAIISHGK 1229
Query: 741 LQCCGSSLFLKQKYGAGYHMTLVKEP----------------------HCNPEDISQLVH 778
L+CCGS LFLK YG GY +TLVK P C+ +SQ +
Sbjct: 1230 LKCCGSPLFLKGTYGDGYRLTLVKRPAEPGGPQEPGLASSPPGRAPLSSCSELQVSQFIR 1289
Query: 779 HHVPNATLESSAGAELSFILPRESTHR--FEGLFAKLEKKQKELGIASFGASITTMEEVF 836
HV + L S ELS+ILP E+ + FE LF LE+ L ++SFG TT+EEVF
Sbjct: 1290 KHVASCLLVSDTSTELSYILPSEAAKKGAFERLFQHLERSLDALHLSSFGLMDTTLEEVF 1349
Query: 837 LRVGK----LVDSSMDIQAIQ---LPALQ--YQHERRASDWAVDSNL------------C 875
L+V + L +S D++ + LP + E A + A S L
Sbjct: 1350 LKVSEEDQSLENSEADVKESRKDVLPGAEGPASGEGHAGNLARCSELTQSQASLQSASSV 1409
Query: 876 GAMDPSDGIG---------------------ALIEEERTAV--------KLNTGLALHCQ 906
G+ +G G +L E E A+ KL+ G L +
Sbjct: 1410 GSARGDEGAGYTDVYGDYRPLFDNPQDPDNVSLQEVEAEALSRVGQGSRKLDGGW-LKVR 1468
Query: 907 QFWAMFLKKAAYSWREWKMVAAQVLVPLTCVTLALLAINYSSELFDDPMLRLTLGEYGRT 966
QF + +K+ + R K + +Q+L+P V +A+ E+ D P L L+ +Y
Sbjct: 1469 QFHGLLVKRFHCARRNSKALFSQILLPAFFVCVAMTVALSVPEIGDLPPLVLSPSQYHNY 1528
Query: 967 VVP 969
P
Sbjct: 1529 TQP 1531
Score = 463 bits (1191), Expect = e-130
Identities = 270/689 (39%), Positives = 401/689 (58%), Gaps = 53/689 (7%)
Query: 1030 RDVGERTVVNALFNNQAYHSPATALAVVDNLLF-----KLLCGPHA-SIVVSNFPQPRSA 1083
R + R +NN+ YHS T L ++N + K P A I V+N P +++
Sbjct: 1750 RKIAVRRAAQVFYNNKGYHSMPTYLNSLNNAILRANLPKSKGNPAAYGITVTNHPMNKTS 1809
Query: 1084 LQAAKDQFNEGRKGFDIALNLLFAMAFLASTFSILAVSERAVQAKHVQFVSGVHVASFWL 1143
+ D +G IA+ ++ AM+F+ ++F + V+E++ +AKH+QFVSG + +WL
Sbjct: 1810 ASLSLDYLLQGTDVV-IAIFIIVAMSFVPASFVVFLVAEKSTKAKHLQFVSGCNPIIYWL 1868
Query: 1144 SALLWDLISFLIPSLLLLVVFKAFDVRAFTRDGHMADTLLLLLLYGWAIIPLMYLMNFFF 1203
+ +WD++++L+P+ +++ FD+ A+T + L L LLYGW+I P+MY +F+F
Sbjct: 1869 ANYVWDMLNYLVPATCCVIILFVFDLPAYTSPTNFPAVLSLFLLYGWSITPIMYPASFWF 1928
Query: 1204 LGAATAYTRLTIFNILSGI----ATFLMVTIMRIPAVKLEELSKTLDHVFLVLPNHCLGM 1259
++AY L + N+ GI ATFL+ +K+ ++ L FL+ PN+ LG
Sbjct: 1929 EVPSSAYVFLIVINLFIGITATVATFLLQLFEHDKDLKV--VNSYLKSCFLIFPNYNLGH 1986
Query: 1260 AVSSFYENYETRRYCTSSEVAAHYCKKYNIQYQENFYAWSAPGVGRFVASMAASGCAYLI 1319
+ N Y Y K ++ + W V R + +MA G +
Sbjct: 1987 GLMEMAYNEYINEY---------YAKIGQFDKMKSPFEWDI--VTRGLVAMAVEGVVGFL 2035
Query: 1320 LLFLIETNLLQRLRGILCALRRRRTLTELYTRMPV----LPEDQDVADERTRILAPSPDS 1375
L + + N L+R + RMPV + +D DVA ER R+L D+
Sbjct: 2036 LTIMCQYNFLRRPQ-----------------RMPVSTKPVEDDVDVASERQRVLRGDADN 2078
Query: 1376 LLHTPLIIKELSKVYEQRV--PLLAVDRLSLAVQKGECFGLLGFNGAGKTTTFKMLTGEE 1433
+ + I+ L+KVY+ R +LAVDRL L V+ GECFGLLG NGAGKT+TFKMLTG+E
Sbjct: 2079 DM---VKIENLTKVYKSRKIGRILAVDRLCLGVRPGECFGLLGVNGAGKTSTFKMLTGDE 2135
Query: 1434 SLTSGDAFVGGHRISSDVGKVRQRIGYCPQFDALLDHMTGREMLVMYARLRGIPERHIGA 1493
S T G+AFV GH + ++ +V+Q +GYCPQ DAL D +T RE L +Y RLRGI +
Sbjct: 2136 STTGGEAFVNGHSVLKELLQVQQSLGYCPQCDALFDELTAREHLQLYTRLRGISWKDEAR 2195
Query: 1494 CVENTLRGLLLEPHANKLVRTYSGGNKRKLSTGIALIGEPAVIFLDEPSTGMDPVARRLL 1553
V+ L L L +A+K TYSGGNKRKLST IALIG PA IFLDEP+TGMDP ARR L
Sbjct: 2196 VVKWALEKLELTKYADKPAGTYSGGNKRKLSTAIALIGYPAFIFLDEPTTGMDPKARRFL 2255
Query: 1554 WDTVARARESGKAIIITSHSMEECEALCTRLAIMVQGQFKCLGSPQHLKSKFGSGYSLRA 1613
W+ + ++G+++++TSHSMEECEALCTRLAIMV G+ +CLGS QHLK++FG GY +
Sbjct: 2256 WNLILDLIKTGRSVVLTSHSMEECEALCTRLAIMVNGRLRCLGSIQHLKNRFGDGYMITV 2315
Query: 1614 KVQSEGQQEALEEFKAFVDLTFPGSVLEDEHQGMVHYHLPGRDLSWAKVFGILEKAKEKY 1673
+ +S +++++ F + FP ++L++ H V Y L +S A+VF +E+
Sbjct: 2316 RTKS---SQSVKDVVRFFNRNFPEAMLKERHHTKVQYQLKSEHISLAQVFSKMEQVSGVL 2372
Query: 1674 GVDDYSVSQISLEQVFLSFAHLQPPTAEE 1702
G++DYSVSQ +L+ VF++FA Q E+
Sbjct: 2373 GIEDYSVSQTTLDNVFVNFAKKQSDNLEQ 2401
Score = 214 bits (545), Expect = 6e-55
Identities = 175/621 (28%), Positives = 296/621 (47%), Gaps = 44/621 (7%)
Query: 253 DPFLVAIQYQLPLLLLLSFTYTALTIARAVVQEKERRLKEYMRMMGLSSWLHWSAWFLLF 312
D L + + ++++ ++ + +V EK + K + G + ++W A ++
Sbjct: 1815 DYLLQGTDVVIAIFIIVAMSFVPASFVVFLVAEKSTKAKHLQFVSGCNPIIYWLANYVWD 1874
Query: 313 FLFLLIAASFMTLLFCVKVKPNVAVLSRSDPSLVLAFLLCFAISTISFSFMVSTFFSKAN 372
L L+ A+ ++ V P A S ++ VL+ L + S + S +F +
Sbjct: 1875 MLNYLVPATCCVIILFVFDLP--AYTSPTNFPAVLSLFLLYGWSITPIMYPASFWFEVPS 1932
Query: 373 MAAAFGGFLYFF--------TYIPYFFVAPRYNWMTLSQ-KLCSCLLSNVAMAMGA---- 419
A F + F T++ F + + S K C + N + G
Sbjct: 1933 SAYVFLIVINLFIGITATVATFLLQLFEHDKDLKVVNSYLKSCFLIFPNYNLGHGLMEMA 1992
Query: 420 --QLIGKFEAKGMGIQWRDLLSPVNVDDDFCFGQVLGMLLLDSVLYGLVTWYMEAVFPGQ 477
+ I ++ AK +G Q+ + SP D V GLV +E V
Sbjct: 1993 YNEYINEYYAK-IG-QFDKMKSPFE---------------WDIVTRGLVAMAVEGVVGFL 2035
Query: 478 FGVPQPWYFFIMPSYWCGKPRAVAGKEEEDSDPEKALRNEYFEAEPEDLVAGIKIKHLSK 537
+ + F P + V + S+ ++ LR + D+V KI++L+K
Sbjct: 2036 LTIMCQYNFLRRPQRMPVSTKPVEDDVDVASERQRVLRGD----ADNDMV---KIENLTK 2088
Query: 538 VFRVGNKDRA-AVRDLNLNLYEGQITVLLGHNGAGKTTTLSMLTGLFPPTSGRAYISGYE 596
V++ R AV L L + G+ LLG NGAGKT+T MLTG T G A+++G+
Sbjct: 2089 VYKSRKIGRILAVDRLCLGVRPGECFGLLGVNGAGKTSTFKMLTGDESTTGGEAFVNGHS 2148
Query: 597 ISQDMVQIRKSLGLCPQHDILFDNLTVAEHLYFYAQLKGLSRQKCPEEVKQMLHIIGLED 656
+ ++++Q+++SLG CPQ D LFD LT EHL Y +L+G+S + VK L + L
Sbjct: 2149 VLKELLQVQQSLGYCPQCDALFDELTAREHLQLYTRLRGISWKDEARVVKWALEKLELTK 2208
Query: 657 KWNSRSRFLSGGMRRKLSIGIALIAGSKVLILDEPTSGMDAISRRAIWDL-LQRQKSDRT 715
+ + SGG +RKLS IALI + LDEPT+GMD +RR +W+L L K+ R+
Sbjct: 2209 YADKPAGTYSGGNKRKLSTAIALIGYPAFIFLDEPTTGMDPKARRFLWNLILDLIKTGRS 2268
Query: 716 IVLTTHFMDEADLLGDRIAIMAKGELQCCGSSLFLKQKYGAGYHMTLVKEPHCNPEDISQ 775
+VLT+H M+E + L R+AIM G L+C GS LK ++G GY +T+ + + +D+ +
Sbjct: 2269 VVLTSHSMEECEALCTRLAIMVNGRLRCLGSIQHLKNRFGDGYMITVRTKSSQSVKDVVR 2328
Query: 776 LVHHHVPNATLESSAGAELSFILPRESTHRFEGLFAKLEKKQKELGIASFGASITTMEEV 835
+ + P A L+ ++ + L E + +F+K+E+ LGI + S TT++ V
Sbjct: 2329 FFNRNFPEAMLKERHHTKVQYQLKSEHISLAQ-VFSKMEQVSGVLGIEDYSVSQTTLDNV 2387
Query: 836 FLRVGKLVDSSMDIQAIQLPA 856
F+ K +++ Q + P+
Sbjct: 2388 FVNFAKKQSDNLEQQETEPPS 2408
Score = 189 bits (479), Expect = 3e-47
Identities = 120/366 (32%), Positives = 193/366 (52%), Gaps = 28/366 (7%)
Query: 1351 RMPVLPEDQDVADERTRI--LAPSPDSLLHTPLII--KELSKVYEQRVPLLAVDRLSLAV 1406
R+ V+ EDQ A E R + H PL++ +L+KVY+ L A+++LSL +
Sbjct: 987 RLSVMEEDQACAMESRRFEETRGMEEEPTHLPLVVCVDKLTKVYKDDKKL-ALNKLSLNL 1045
Query: 1407 QKGECFGLLGFNGAGKTTTFKMLTGEESLTSGDAFVGGHRISSDVGKVRQRIGYCPQFDA 1466
+ + LG NGAGKTTT +LTG TSG A + GH I +++ ++R+ +G CPQ +
Sbjct: 1046 YENQVVSFLGHNGAGKTTTMSILTGLFPPTSGSATIYGHDIRTEMDEIRKNLGMCPQHNV 1105
Query: 1467 LLDHMTGREMLVMYARLRGIPERHIGACVENTLRGLLLEPHANKLVRTYSGGNKRKLSTG 1526
L D +T E L Y+RL+ + + I ++ + L L + LV+T SGG KRKLS
Sbjct: 1106 LFDRLTVEEHLWFYSRLKSMAQEEIRREMDKMIEDLELSNKRHSLVQTLSGGMKRKLSVA 1165
Query: 1527 IALIGEPAVIFLDEPSTGMDPVARRLLWDTVARARESGKAIIITSHSMEECEALCTRLAI 1586
IA +G I LDEP+ G+DP ARR +WD + + + G+ I++++H M+E + L R+AI
Sbjct: 1166 IAFVGGSRAIILDEPTAGVDPYARRAIWDLILKYK-PGRTILLSTHHMDEADLLGDRIAI 1224
Query: 1587 MVQGQFKCLGSPQHLKSKFGSGYSL---RAKVQSEGQQE----------------ALEEF 1627
+ G+ KC GSP LK +G GY L + + G QE + +
Sbjct: 1225 ISHGKLKCCGSPLFLKGTYGDGYRLTLVKRPAEPGGPQEPGLASSPPGRAPLSSCSELQV 1284
Query: 1628 KAFVDLTFPGSVLEDEHQGMVHYHLP---GRDLSWAKVFGILEKAKEKYGVDDYSVSQIS 1684
F+ +L + + Y LP + ++ ++F LE++ + + + + +
Sbjct: 1285 SQFIRKHVASCLLVSDTSTELSYILPSEAAKKGAFERLFQHLERSLDALHLSSFGLMDTT 1344
Query: 1685 LEQVFL 1690
LE+VFL
Sbjct: 1345 LEEVFL 1350
>gi|150417984 ATP-binding cassette, sub-family A, member 7 [Homo
sapiens]
Length = 2146
Score = 495 bits (1275), Expect = e-139
Identities = 313/866 (36%), Positives = 460/866 (53%), Gaps = 94/866 (10%)
Query: 181 TTSLFPLFPNPGPREPTSPDGGEPGYIREGFLAVQHAVDRAIMEYHADAATRQLFQRLTV 240
T + F +PGP D Y+ GF+ +Q V+RA + + A R +
Sbjct: 476 TNKIRDRFWDPGPAADPLTD---LRYVWGGFVYLQDLVERAAVRVLSGANPRA-----GL 527
Query: 241 TIKRFPYPPFIADPFLVAIQYQLPLLLLLSFTYTALTIARAVVQEKERRLKEYMRMMGLS 300
+++ PYP ++ D FL + LPL L L++ Y+ +AVV+EKE RL++ MR MGLS
Sbjct: 528 YLQQMPYPCYVDDVFLRVLSRSLPLFLTLAWIYSVTLTVKAVVREKETRLRDTMRAMGLS 587
Query: 301 SWLHWSAWFLLFFLFLLIAASFMTLLFCVKVKPNVAVLSRSDPSLVLAFLLCFAISTISF 360
+ W WFL L++A+ + L+ + +L S P +V FL FA++T++
Sbjct: 588 RAVLWLGWFLSCLGPFLLSAALLVLVLKLG-----DILPYSHPGVVFLFLAAFAVATVTQ 642
Query: 361 SFMVSTFFSKANMAAAFGGFLYFFTYIPYFFVAPRYNWMTLSQKLCSCLLSNVAMAMGAQ 420
SF++S FFS+AN+AAA GG YF Y+PY + + ++ + LLS VA G +
Sbjct: 643 SFLLSAFFSRANLAAACGGLAYFSLYLPYVLCVAWRDRLPAGGRVAASLLSPVAFGFGCE 702
Query: 421 LIGKFEAKGMGIQWRDLLSPVNVDDDFCFGQVLGMLLLDSVLYGLVTWYMEAVFPGQFGV 480
+ E +G G QW ++ + D F QV G+LLLD+ LYGL TWY+EAV PGQ+G+
Sbjct: 703 SLALLEEQGEGAQWHNVGTRPTADV-FSLAQVSGLLLLDAALYGLATWYLEAVCPGQYGI 761
Query: 481 PQPWYFFIMPSYWCG-KPRAVAGKEEEDSDPEKALRNEYFEAEPEDLVAGIKIKHLSKVF 539
P+PW F SYWCG +P DP+ + E P L G+ ++ L K
Sbjct: 762 PEPWNFPFRRSYWCGPRPPKSPAPCPTPLDPKVLV-----EEAPPGLSPGVSVRSLEK-- 814
Query: 540 RVGNKDRAAVRDLNLNLYEGQITVLLGHNGAGKTTTLSMLTGLFPPTSGRAYISGYEISQ 599
R + A+R L+L+ Y+G IT LGHNGAGKTTTLS+L+GLFPP+ G A+I G+++
Sbjct: 815 RFPGSPQPALRGLSLDFYQGHITAFLGHNGAGKTTTLSILSGLFPPSGGSAFILGHDVRS 874
Query: 600 DMVQIRKSLGLCPQHDILFDNLTVAEHLYFYAQLKGLSRQKCPEEVKQMLHIIGLEDKWN 659
M IR LG+CPQ+++LFD LTV EH++FY +LKGLS E ++L +GL K +
Sbjct: 875 SMAAIRPHLGVCPQYNVLFDMLTVDEHVWFYGRLKGLSAAVVGPEQDRLLQDVGLVSKQS 934
Query: 660 SRSRFLSGGMRRKLSIGIALIAGSKVLILDEPTSGMDAISRRAIWDLLQRQKSDRTIVLT 719
++R LSGGM+RKLS+ IA + GS+V+ILDEPT+G+D SRR IW+LL + + RT++L+
Sbjct: 935 VQTRHLSGGMQRKLSVAIAFVGGSQVVILDEPTAGVDPASRRGIWELLLKYREGRTLILS 994
Query: 720 THFMDEADLLGDRIAIMAKGELQCCGSSLFLKQKYGAGYHMTLVKE-------------- 765
TH +DEA+LLGDR+A++A G L CCGS LFL++ G+GY++TLVK
Sbjct: 995 THHLDEAELLGDRVAVVAGGRLCCCGSPLFLRRHLGSGYYLTLVKARLPLTTNEKADTDM 1054
Query: 766 ----------------PHCNPEDISQLVHHHVPNATLESSAGAELSFILPRESTH--RFE 807
+ LV H VP A L EL +LP H F
Sbjct: 1055 EGSVDTRQEKKNGSQGSRVGTPQLLALVQHWVPGARLVEELPHELVLVLPYTGAHDGSFA 1114
Query: 808 GLFAKLEKKQKELGIASFGASITTMEEVFLRVGKLVDSSMDIQAIQLPALQYQHERRASD 867
LF +L+ + EL + +G S T++EE+FL+V + + D++ D
Sbjct: 1115 TLFRELDTRLAELRLTGYGISDTSLEEIFLKVVEECAADTDME----------------D 1158
Query: 868 WAVDSNLC------------------GAMDPSDGIGALIEEER----TAVKLNTGLALHC 905
+ +LC A++ + G+ E ++ AV G AL
Sbjct: 1159 GSCGQHLCTGIAGLDVTLRLKMPPQETALENGEPAGSAPETDQGSGPDAVGRVQGWALTR 1218
Query: 906 QQFWAMFLKKAAYSWREWKMVAAQVLVPLTCVTLALLAINYSSELFDDPMLRLTLGEYGR 965
QQ A+ LK+ + R + + AQ+++P V LAL+ P LRL+ YG
Sbjct: 1219 QQLQALLLKRFLLARRSRRGLFAQIVLPALFVGLALVFSLIVPPFGHYPALRLSPTMYGA 1278
Query: 966 TVVPFS--VPGTSQLGQQLSEHLKDA 989
V FS PG + L L++A
Sbjct: 1279 QVSFFSEDAPGDPGRARLLEALLQEA 1304
Score = 452 bits (1164), Expect = e-126
Identities = 265/666 (39%), Positives = 398/666 (59%), Gaps = 53/666 (7%)
Query: 1042 FNNQAYHSPATALAVVDNLLFKLLCGP----HA-SIVVSNFPQPRSALQAAKDQFNEGR- 1095
FNN+ +HS + N + + P HA SI N P L K+Q +EG
Sbjct: 1475 FNNKGWHSMVAFVNRASNAILRAHLPPGPARHAHSITTLNHP-----LNLTKEQLSEGAL 1529
Query: 1096 --KGFDIALNL--LFAMAFLASTFSILAVSERAVQAKHVQFVSGVHVASFWLSALLWDLI 1151
D+ +++ +FAM+F+ ++F+++ + ER +AKH+Q + G+ +WL LWD+
Sbjct: 1530 MASSVDVLVSICVVFAMSFVPASFTLVLIEERVTRAKHLQLMGGLSPTLYWLGNFLWDMC 1589
Query: 1152 SFLIPSLLLLVVFKAFDVRAFTRDGHMADTLLLLLLYGWAIIPLMYLMNFFFLGAATAYT 1211
++L+P+ +++++F AF RA+ ++ LLLLLLYGW+I PLMY +FFF +TAY
Sbjct: 1590 NYLVPACIVVLIFLAFQQRAYVAPANLPALLLLLLLYGWSITPLMYPASFFFSVPSTAYV 1649
Query: 1212 RLTIFNILSGIATFLMVTIMRIPA-VKLEELSKTLDHVFLVLPNHCLGMAVSSFYENYET 1270
LT N+ GI + ++ + + KL+E+S+ L VFL+ P+ CLG + N
Sbjct: 1650 VLTCINLFIGINGSMATFVLELFSDQKLQEVSRILKQVFLIFPHFCLGRGLIDMVRN--- 1706
Query: 1271 RRYCTSSEVAAHYCKKYNIQYQENFYAWSAPGVGRFVASMAASGCAYLILLFLIETNLLQ 1330
+ A ++ + ++ W VG+ + +M G LFL+ T LLQ
Sbjct: 1707 -------QAMADAFERLGDRQFQSPLRWEV--VGKNLLAMVIQGP-----LFLLFTLLLQ 1752
Query: 1331 RLRGILCALRRRRTLTELYTRMPVL-PEDQDVADERTRILAPSPDSLLHTPLIIKELSKV 1389
+L R R +P+L ED+DVA ER R++ + + L+++ L+KV
Sbjct: 1753 HRSQLLPQPRVRS--------LPLLGEEDEDVARERERVVQGATQGDV---LVLRNLTKV 1801
Query: 1390 YE-QRVPLLAVDRLSLAVQKGECFGLLGFNGAGKTTTFKMLTGEESLTSGDAFVGGHRIS 1448
Y QR+P AVDRL L + GECFGLLG NGAGKT+TF+M+TG+ + G+A + GH ++
Sbjct: 1802 YRGQRMP--AVDRLCLGIPPGECFGLLGVNGAGKTSTFRMVTGDTLASRGEAVLAGHSVA 1859
Query: 1449 SDVGKVRQRIGYCPQFDALLDHMTGREMLVMYARLRGIPERHIGACVENTLRGLLLEPHA 1508
+ +GYCPQ DA+ + +TGRE L + ARLRG+PE + + L L L +A
Sbjct: 1860 REPSAAHLSMGYCPQSDAIFELLTGREHLELLARLRGVPEAQVAQTAGSGLARLGLSWYA 1919
Query: 1509 NKLVRTYSGGNKRKLSTGIALIGEPAVIFLDEPSTGMDPVARRLLWDTVARARESGKAII 1568
++ TYSGGNKRKL+T +AL+G+PAV+FLDEP+TGMDP ARR LW+++ G++++
Sbjct: 1920 DRPAGTYSGGNKRKLATALALVGDPAVVFLDEPTTGMDPSARRFLWNSLLAVVREGRSVM 1979
Query: 1569 ITSHSMEECEALCTRLAIMVQGQFKCLGSPQHLKSKFGSGYSLRAKVQSEGQQEALEEFK 1628
+TSHSMEECEALC+RLAIMV G+F+CLGSPQHLK +F +G++L +V + Q A
Sbjct: 1980 LTSHSMEECEALCSRLAIMVNGRFRCLGSPQHLKGRFAAGHTLTLRVPAARSQPA----A 2035
Query: 1629 AFVDLTFPGSVLEDEHQGMVHYHL-PGRDLSWAKVFGILEKAKEKYGVDDYSVSQISLEQ 1687
AFV FPG+ L + H G + + L PG + A+VFG L ++GV+D+SVSQ LE+
Sbjct: 2036 AFVAAEFPGAELREAHGGRLRFQLPPGGRCALARVFGELAVHGAEHGVEDFSVSQTMLEE 2095
Query: 1688 VFLSFA 1693
VFL F+
Sbjct: 2096 VFLYFS 2101
Score = 194 bits (492), Expect = 8e-49
Identities = 173/635 (27%), Positives = 285/635 (44%), Gaps = 50/635 (7%)
Query: 258 AIQYQLPLLLLLSFTYTALTIARAVVQEKERRLKEYMRMMGLSSWLHWSAWFLLFFLFLL 317
++ + + ++ + ++ + +++E+ R K M GLS L+W FL L
Sbjct: 1533 SVDVLVSICVVFAMSFVPASFTLVLIEERVTRAKHLQLMGGLSPTLYWLGNFLWDMCNYL 1592
Query: 318 IAASFMTLLFCVKVKPNVAVLSRSDPSLVLAFLLCFAISTISFSFMVSTFFSKANMAAAF 377
+ A + L+F + + V + P+L+L LL + S + S FFS + A
Sbjct: 1593 VPACIVVLIF-LAFQQRAYVAPANLPALLLLLLL-YGWSITPLMYPASFFFSVPSTAYVV 1650
Query: 378 GGFLYFF--------TYIPYFFVAPRYNWMTLSQKLCSCLLSNVAMAMGAQLIGKFEAKG 429
+ F T++ F + +S+ L L +G LI +
Sbjct: 1651 LTCINLFIGINGSMATFVLELFSDQKLQ--EVSRILKQVFLIFPHFCLGRGLIDMVRNQA 1708
Query: 430 MGIQW-----RDLLSPVNVDDDFCFGQVLGMLLLDSVLYGLVTWYMEAVFPGQFGV-PQP 483
M + R SP+ +V+G LL V+ G + + + + PQP
Sbjct: 1709 MADAFERLGDRQFQSPLR-------WEVVGKNLLAMVIQGPLFLLFTLLLQHRSQLLPQP 1761
Query: 484 WYFFIMPSYWCGKPRAVAGKEEEDSDPEKALRNEYFEAEPEDLVAGIKIKHLSKVFRVGN 543
+ R++ EED D + A D++ +++L+KV+R
Sbjct: 1762 ------------RVRSLPLLGEEDEDVARERERVVQGATQGDVLV---LRNLTKVYR--G 1804
Query: 544 KDRAAVRDLNLNLYEGQITVLLGHNGAGKTTTLSMLTGLFPPTSGRAYISGYEISQDMVQ 603
+ AV L L + G+ LLG NGAGKT+T M+TG + G A ++G+ ++++
Sbjct: 1805 QRMPAVDRLCLGIPPGECFGLLGVNGAGKTSTFRMVTGDTLASRGEAVLAGHSVAREPSA 1864
Query: 604 IRKSLGLCPQHDILFDNLTVAEHLYFYAQLKGLSRQKCPEEVKQMLHIIGLEDKWNSRSR 663
S+G CPQ D +F+ LT EHL A+L+G+ + + L +GL + +
Sbjct: 1865 AHLSMGYCPQSDAIFELLTGREHLELLARLRGVPEAQVAQTAGSGLARLGLSWYADRPAG 1924
Query: 664 FLSGGMRRKLSIGIALIAGSKVLILDEPTSGMDAISRRAIWD-LLQRQKSDRTIVLTTHF 722
SGG +RKL+ +AL+ V+ LDEPT+GMD +RR +W+ LL + R+++LT+H
Sbjct: 1925 TYSGGNKRKLATALALVGDPAVVFLDEPTTGMDPSARRFLWNSLLAVVREGRSVMLTSHS 1984
Query: 723 MDEADLLGDRIAIMAKGELQCCGSSLFLKQKYGAGYHMTLVKEPHCNPEDISQLVHHHVP 782
M+E + L R+AIM G +C GS LK ++ AG+ +TL + P + + V P
Sbjct: 1985 MEECEALCSRLAIMVNGRFRCLGSPQHLKGRFAAGHTLTL-RVPAARSQPAAAFVAAEFP 2043
Query: 783 NATLESSAGAELSFILPRESTHRFEGLFAKLEKKQKELGIASFGASITTMEEVFLRVGKL 842
A L + G L F LP +F +L E G+ F S T +EEVFL K
Sbjct: 2044 GAELREAHGGRLRFQLPPGGRCALARVFGELAVHGAEHGVEDFSVSQTMLEEVFLYFSKD 2103
Query: 843 VDSSMDIQAIQL------PALQYQHERRASDWAVD 871
D + + PA QH +R S + D
Sbjct: 2104 QGKDEDTEEQKEAGVGVDPAPGLQHPKRVSQFLDD 2138
Score = 167 bits (423), Expect = 8e-41
Identities = 108/326 (33%), Positives = 165/326 (50%), Gaps = 31/326 (9%)
Query: 1395 PLLAVDRLSLAVQKGECFGLLGFNGAGKTTTFKMLTGEESLTSGDAFVGGHRISSDVGKV 1454
P A+ LSL +G LG NGAGKTTT +L+G + G AF+ GH + S + +
Sbjct: 820 PQPALRGLSLDFYQGHITAFLGHNGAGKTTTLSILSGLFPPSGGSAFILGHDVRSSMAAI 879
Query: 1455 RQRIGYCPQFDALLDHMTGREMLVMYARLRGIPERHIGACVENTLRGLLLEPHANKLVRT 1514
R +G CPQ++ L D +T E + Y RL+G+ +G + L+ + L + R
Sbjct: 880 RPHLGVCPQYNVLFDMLTVDEHVWFYGRLKGLSAAVVGPEQDRLLQDVGLVSKQSVQTRH 939
Query: 1515 YSGGNKRKLSTGIALIGEPAVIFLDEPSTGMDPVARRLLWDTVARARESGKAIIITSHSM 1574
SGG +RKLS IA +G V+ LDEP+ G+DP +RR +W+ + + RE G+ +I+++H +
Sbjct: 940 LSGGMQRKLSVAIAFVGGSQVVILDEPTAGVDPASRRGIWELLLKYRE-GRTLILSTHHL 998
Query: 1575 EECEALCTRLAIMVQGQFKCLGSPQHLKSKFGSGYSL-------------RAKVQSEGQQ 1621
+E E L R+A++ G+ C GSP L+ GSGY L +A EG
Sbjct: 999 DEAELLGDRVAVVAGGRLCCCGSPLFLRRHLGSGYYLTLVKARLPLTTNEKADTDMEGSV 1058
Query: 1622 EALEEFK--------------AFVDLTFPGSVLEDEHQGMVHYHLP---GRDLSWAKVFG 1664
+ +E K A V PG+ L +E + LP D S+A +F
Sbjct: 1059 DTRQEKKNGSQGSRVGTPQLLALVQHWVPGARLVEELPHELVLVLPYTGAHDGSFATLFR 1118
Query: 1665 ILEKAKEKYGVDDYSVSQISLEQVFL 1690
L+ + + Y +S SLE++FL
Sbjct: 1119 ELDTRLAELRLTGYGISDTSLEEIFL 1144
Score = 36.2 bits (82), Expect = 0.28
Identities = 18/43 (41%), Positives = 27/43 (62%)
Query: 1 MAVLRQLALLLWKNYTLQKRKVLVTVLELFLPLLFSGILIWLR 43
MA QL LLLWKN+ ++R+ + ++EL PL IL+ +R
Sbjct: 1 MAFWTQLMLLLWKNFMYRRRQPVQLLVELLWPLFLFFILVAVR 43
Score = 35.0 bits (79), Expect = 0.62
Identities = 30/111 (27%), Positives = 52/111 (46%), Gaps = 5/111 (4%)
Query: 1101 ALNLLFAMAFLAS-TFSILAV-SERAVQAKHVQFVSGVHVASFWLSALLWDLISFLIPSL 1158
+L L +A++ S T ++ AV E+ + + G+ A WL L L FL+ +
Sbjct: 549 SLPLFLTLAWIYSVTLTVKAVVREKETRLRDTMRAMGLSRAVLWLGWFLSCLGPFLLSAA 608
Query: 1159 LLLVVFKAFDVRAFTRDGHMADTLLLLLLYGWAIIPLMYLMNFFFLGAATA 1209
LL++V K D+ ++ H L L + A + +L++ FF A A
Sbjct: 609 LLVLVLKLGDILPYS---HPGVVFLFLAAFAVATVTQSFLLSAFFSRANLA 656
>gi|27436953 ATP-binding cassette, sub-family A, member 6 [Homo
sapiens]
Length = 1617
Score = 493 bits (1270), Expect = e-139
Identities = 446/1735 (25%), Positives = 814/1735 (46%), Gaps = 188/1735 (10%)
Query: 2 AVLRQLALLLWKNYTLQKRKVLVTVLELFLPLLFSGILIWLRLKIQSENVPNATIYPGQS 61
+V +Q LL KN+ + R ++LE L IL+ L + + S ++ N +PG +
Sbjct: 7 SVYQQTKALLCKNFLKKWRMKRESLLEWGL-----SILLGLCIALFSSSMRNVQ-FPGMA 60
Query: 62 IQELPLFFTFPPPGDTWELAYIPSHSDAAKTVTETVRRALVINMRVRGFPSEKDFEDYIR 121
Q L F + + Y P + + + +T L+ V G P+ K D I
Sbjct: 61 PQNLGRVDKFN--SSSLMVVYTPISNLTQQIMNKTALAPLLKGTSVIGAPN-KTHMDEIL 117
Query: 122 YDNCSSSVLAAVVFEHPFNHSKEPLPLAVKYHLRFSYTRRNYMWTQTGSFFLKETEGWHT 181
+N ++ ++F F+ Y L F + +W + S + G +
Sbjct: 118 LENLPYAM--GIIFNETFS-----------YKLIFFQGYNSPLWKEDFSAHCWDGYGEFS 164
Query: 182 TSLFPLFPNPGPREPTSPDGGEPGYIREGFLAVQHAVDRAIMEYHADAATRQLFQRLT-V 240
+L Y GF+A+Q A++ AI+E + + +T +
Sbjct: 165 CTLTK-------------------YWNRGFVALQTAINTAIIEITTNHPVMEELMSVTAI 205
Query: 241 TIKRFPYPPFIADPFLVAIQYQLPLLLLLSFTYTALTIARAVVQEKERRLKEYMRMMGLS 300
T+K P FI L + L LL F+ I+ V +E+++ K M+MMGL
Sbjct: 206 TMKTLP---FITKNLLHNEMFIL--FFLLHFSPLVYFISLNVTKERKKS-KNLMKMMGLQ 259
Query: 301 SWLHWSAWFLLFFLFLLIAASFMTLLFCVKVKPNVAVLSRSDPSLVLAFLLCFAISTISF 360
W +W L++ F+ I + F+T++ + V++ +L FL + +S ++
Sbjct: 260 DSAFWLSWGLIYAGFIFIISIFVTIIITFT---QIIVMTGFMVIFILFFL--YGLSLVAL 314
Query: 361 SFMVSTFFSKANMAAAFGGFLYFFTYIPYFFVAPRYNWMTLSQKLCSCLLSNVAMAMGAQ 420
F++S KA + L F F V Y + S + + S A G
Sbjct: 315 VFLMSVLLKKAVLTNLVVFLLTLFWGCLGFTVF--YEQLPSSLEWILNICSPFAFTTGMI 372
Query: 421 LIGKFEAKGMGIQWRDLLSPVNVDDDFCFGQVLGMLLLDSVLYGLVTWYMEAVFPGQFGV 480
I K + G+ + P D + MLLLD ++Y L+ Y + + P +G
Sbjct: 373 QIIKLDYNLNGV-----IFPDPSGDSYTMIATFSMLLLDGLIYLLLALYFDKILP--YGD 425
Query: 481 PQPW--YFFIMPSYWCGKPRAVAGKEEEDSDPEKALRNEYFEAEPEDLVA--GIKIKHLS 536
+ + FF+ S R A E++ D E ++YFE + I+I+++
Sbjct: 426 ERHYSPLFFLNSSSCFQHQRTNAKVIEKEIDAEHP-SDDYFEPVAPEFQGKEAIRIRNVK 484
Query: 537 KVFRVGNKDRAAVRDLNLNLYEGQITVLLGHNGAGKTTTLSMLTGLFPPTSGRAYISGYE 596
K ++ + A++ L ++YEGQIT +LGH+GAGK++ L++L GL PT G I
Sbjct: 485 KEYKGKSGKVEALKGLLFDIYEGQITAILGHSGAGKSSLLNILNGLSVPTEGSVTIYNKN 544
Query: 597 IS--QDMVQIRKSLGLCPQHDILFDNLTVAEHLYFYAQLKGLSRQKCPEEVKQMLHIIGL 654
+S QD+ +IRK G+CPQ ++ FD LTV E+L +A++KG+ ++ +EV+++L + +
Sbjct: 545 LSEMQDLEEIRKITGVCPQFNVQFDILTVKENLSLFAKIKGIHLKEVEQEVQRILLELDM 604
Query: 655 EDKWNSRSRFLSGGMRRKLSIGIALIAGSKVLILDEPTSGMDAISRRAIWDLLQRQKSDR 714
++ ++ ++ LS G +RKL+ GI ++ ++L+LDEPT+G+D SR +W LL+ +++D
Sbjct: 605 QNIQDNLAKHLSEGQKRKLTFGITILGDPQILLLDEPTTGLDPFSRDQVWSLLRERRADH 664
Query: 715 TIVLTTHFMDEADLLGDRIAIMAKGELQCCGSSLFLKQKYGAGYHMTLVKEPHCNPEDIS 774
I+ +T MDEAD+L DR IM+ G L+C GSS+FLK+++G GYH++L + CNPE I+
Sbjct: 665 VILFSTQSMDEADILADRKVIMSNGRLKCAGSSMFLKRRWGLGYHLSLHRNEICNPEQIT 724
Query: 775 QLVHHHVPNATLESSAGAELSFILPRESTHRFEGLFAKLEKKQKELGIASFGASITTMEE 834
+ HH+P+A L++ +L + LP E T+ F LF+ L+K + G+ + S++T+ E
Sbjct: 725 SFITHHIPDAKLKTENKEKLVYTLPLERTNTFPDLFSDLDKCSDQ-GVTGYDISMSTLNE 783
Query: 835 VFLRVGKLVDSSMDIQAIQLPALQYQHERRASDWAVDSNLCGAMDPSDGIGALIEEERTA 894
VF+++ D + +++ DS M+ + + E +TA
Sbjct: 784 VFMKLEGQSTIEQDFEQVEM--------------IRDSESLNEMELAH---SSFSEMQTA 826
Query: 895 VKLNTGLALHCQQFWAMFLKKAAYSWREWKMVAAQVLV------PLTCVTLALLAINYSS 948
V + + L Q +AM + R+ K++ +LV PL + +N
Sbjct: 827 V---SDMGLWRMQVFAMARLRFLKLKRQTKVLLTLLLVFGIAIFPLIVENIMYAMLNEKI 883
Query: 949 EL-FDDPMLRLTLGEYGRTVVPFSVPGTSQLGQQLSE-HLKDALQAEGQEPREVLGDLEE 1006
+ F + + L+ G+ + P TS L +E +++D +++ + + +L ++++
Sbjct: 884 DWEFKNELYFLSPGQLPQE------PRTSLLIINNTESNIEDFIKS--LKHQNILLEVDD 935
Query: 1007 FLIFRASVEGGGFNERCLVAASFRDVGERTVVNALFNNQAYHSPATALAVVDNLLFKLL- 1065
F R +G +N +V+ +D + + N + H + ++ N L ++
Sbjct: 936 F-ENRNGTDGLSYNGAIIVSGKQKDYR----FSVVCNTKRLHCFPILMNIISNGLLQMFN 990
Query: 1066 CGPHASIVVSNFPQPRSALQAAKDQFNEGRKGFDIALNLLFAMAFLASTFSILAVSERAV 1125
H I S FP L D + L + ++ ++ ++S+
Sbjct: 991 HTQHIRIESSPFPLSHIGLWTGLP---------DGSFFLFLVLCSISPYITMGSISDYKK 1041
Query: 1126 QAKHVQFVSGVHVASFWLSALLWDLISFLIPSLLLLVVFKAFDVRAFTRDGHMADTLLLL 1185
AK ++SG++ +++W L D+ F++ LL+ ++F +++ + L+++
Sbjct: 1042 NAKSQLWISGLYTSAYWCGQALVDVSFFILILLLMYLIFYIENMQYLLITSQIVFALVIV 1101
Query: 1186 LL-YGWAIIPLMYLMNFFFLGAATAYTRLTIFNILSGIATFLMVTIMRIPAVKLEELSKT 1244
Y +++ +Y+++F F +++ A+ +M +I I L L T
Sbjct: 1102 TPGYAASLVFFIYMISFIF---RKRRKNSGLWSFYFFFASTIMFSITLINHFDLSILITT 1158
Query: 1245 LDHVFLVLPNHCLGMAVSSFYENYETRRYCTSSEVAAHYCKKYNIQYQENFYAWSAPGVG 1304
+ +++P++ L + +F E + Y E NF + +
Sbjct: 1159 M----VLVPSYTL-LGFKTFLEVRDQEHYREFPEA--------------NFELSATDFLV 1199
Query: 1305 RFVASMAASGCAYLILLFLIETNLLQRLRGILCALRRRRTLTELYTRMP----------- 1353
F+ L+ +F++ R + C +R R ++ P
Sbjct: 1200 CFIPYFQT-----LLFVFVL------RCMELKCGKKRMRK-DPVFRISPQSRDAKPNPEE 1247
Query: 1354 VLPEDQDVADERTRILAPSPDSLL-HTPLIIK---------ELSKVYEQRVPLLAVDRLS 1403
+ ED+D+ ER R S+L P+II + + +R +A +S
Sbjct: 1248 PIDEDEDIQTERIRTATALTTSILDEKPVIIASCLHKEYAGQKKSCFSKRKKKIAARNIS 1307
Query: 1404 LAVQKGECFGLLGFNGAGKTTTFKMLTGEESLTSGDAFVGGHRISSDVGKVRQRIGYCPQ 1463
VQ+GE GLLG NGAGK+++ +M++G T+G+ + G SS +G +GYCPQ
Sbjct: 1308 FCVQEGEILGLLGPNGAGKSSSIRMISGITKPTAGEVELKG--CSSVLG----HLGYCPQ 1361
Query: 1464 FDALLDHMTGREMLVMYARLRGIPERHIGACVENTLRGLLLEPHANKLVRTYSGGNKRKL 1523
+ L +T RE L +YA ++G+ + + + L N V+ + G RKL
Sbjct: 1362 ENVLWPMLTLREHLEVYAAVKGLRKADARLAIARLVSAFKLHEQLNVPVQKLTAGITRKL 1421
Query: 1524 STGIALIGEPAVIFLDEPSTGMDPVARRLLWDTV-ARARESGKAIIITSHSMEECEALCT 1582
++L+G V+ LDEPSTG+DP ++ +W + A + + + +++T+H++ E EALC
Sbjct: 1422 CFVLSLLGNSPVLLLDEPSTGIDPTGQQQMWQAIQAVVKNTERGVLLTTHNLAEAEALCD 1481
Query: 1583 RLAIMVQGQFKCLGSPQHLKSKFGSGYSLRAKVQSEGQQEALEEFKAFVDLTFPGSVLED 1642
R+AIMV G+ +C+GS QHLK+K G Y L KV+ Q + + FP + ++
Sbjct: 1482 RVAIMVSGRLRCIGSIQHLKNKLGKDYILELKVKETSQVTLVH---TEILKLFPQAAGQE 1538
Query: 1643 EHQGMVHYHLPGRDL-SWAKVFGILEKAKEKYGVDDYSVSQISLEQVFLSFAHLQ 1696
+ ++ Y LP D+ ++ F LE K + +++YS+SQ +LE+VFL + Q
Sbjct: 1539 RYSSLLTYKLPVADVYPLSQTFHKLEAVKHNFNLEEYSLSQCTLEKVFLELSKEQ 1593
>gi|27881501 ATP-binding cassette, sub-family A, member 12 isoform b
[Homo sapiens]
Length = 2277
Score = 476 bits (1225), Expect = e-134
Identities = 292/858 (34%), Positives = 469/858 (54%), Gaps = 86/858 (10%)
Query: 126 SSSVLAAVVFEHPFNHSKEP--------LPLAVKYHLRFSYTRRNYMWTQTGSFFLKETE 177
S+ + +V+F+ P N S LP +KY +R S LK +
Sbjct: 631 SNELFGSVIFKLPSNRSWHRGYDSGNVFLPPVIKYTIRMS---------------LKTAQ 675
Query: 178 GWHTTSLFPLFPNPGPREPTSPDGGEPGYIREGFLAVQHAVDRAIMEYHADAATRQLFQR 237
T SL PGP SP + F+ +Q +++RAI+E T + Q
Sbjct: 676 T--TRSLRTKIWAPGPHN--SPSHNQ--IYGRAFIYLQDSIERAIIELQ----TGRNSQE 725
Query: 238 LTVTIKRFPYPPFIADPFLVAIQYQLPLLLLLSFTYTALTIARAVVQEKERRLKEYMRMM 297
+ V ++ PYP F+ D FL ++ Y LP++L++++ + +V EK+ RL EYM+MM
Sbjct: 726 IAVQVQAIPYPCFMKDNFLTSVSYSLPIVLMVAWVVFIAAFVKKLVYEKDLRLHEYMKMM 785
Query: 298 GLSSWLHWSAWFLLFFLFLLIAASFMTLLFCVKVKPNVAVLSRSDPSLVLAFLLCFAIST 357
G++S H+ AW + FLL+ T++ + + +L +++ ++ + ++ S
Sbjct: 786 GVNSCSHFFAWLIESVGFLLV-----TIVILIIILKFGNILPKTNGFILFLYFSDYSFSV 840
Query: 358 ISFSFMVSTFFSKANMAAAFGGFLYFFTYIPYFFVAPRYNWMTLSQKLCSCLLSNVAMAM 417
I+ S+++S FF+ N+AA G +Y + P+ + N ++ K+ LLS A +
Sbjct: 841 IAMSYLISVFFNNTNIAALIGSLIYIIAFFPFIVLVTVENELSYVLKVFMSLLSPTAFSY 900
Query: 418 GAQLIGKFEAKGMGIQWRDLLSPVNVDDDFCFGQVLGMLLLDSVLYGLVTWYMEAVFPGQ 477
+Q I ++E +G+G+QW ++ + DD FG + ++L DS +Y L+ WY+ VFPG
Sbjct: 901 ASQYIARYEEQGIGLQWENMYTSPVQDDTTSFGWLCCLILADSFIYFLIAWYVRNVFPGT 960
Query: 478 FGVPQPWYFFIMPSYW-----CG--KPRAVAG--------KEEEDSDPEKALRNEYFEAE 522
+G+ PWYF I+PSYW C KP G + S + + + E E
Sbjct: 961 YGMAAPWYFPILPSYWKERFGCAEVKPEKSNGLMFTNIMMQNTNPSASPEYMFSSNIEPE 1020
Query: 523 PEDLVAGIKIKHLSKVFRVGNKDRAAVRDLNLNLYEGQITVLLGHNGAGKTTTLSMLTGL 582
P+DL G+ + ++K++ G+K AV +LNLN YEG IT LLG NGAGKTTT+SMLTGL
Sbjct: 1021 PKDLTVGVALHGVTKIY--GSK--VAVDNLNLNFYEGHITSLLGPNGAGKTTTISMLTGL 1076
Query: 583 FPPTSGRAYISGYEISQDMVQIRKSLGLCPQHDILFDNLTVAEHLYFYAQLK--GLSRQK 640
F ++G ++ G +I D+ +RK++G+C QHD+LF LT EHL Y +K ++++
Sbjct: 1077 FGASAGTIFVYGKDIKTDLHTVRKNMGVCMQHDVLFSYLTTKEHLLLYGSIKVPHWTKKQ 1136
Query: 641 CPEEVKQMLHIIGLEDKWNSRSRFLSGGMRRKLSIGIALIAGSKVLILDEPTSGMDAISR 700
EEVK+ L GL + R LSGGM+RKLSI IALI GS+V+ILDEP++G+D SR
Sbjct: 1137 LHEEVKRTLKDTGLYSHRHKRVGTLSGGMKRKLSISIALIGGSRVVILDEPSTGVDPCSR 1196
Query: 701 RAIWDLLQRQKSDRTIVLTTHFMDEADLLGDRIAIMAKGELQCCGSSLFLKQKYGAGYHM 760
R+IWD++ + K+ RTI+L+TH +DEA++L DRIA + +G L+CCGS +LK+ +G GYH+
Sbjct: 1197 RSIWDVISKNKTARTIILSTHHLDEAEVLSDRIAFLEQGGLRCCGSPFYLKEAFGDGYHL 1256
Query: 761 TLVKEPH--------CNPEDISQLVHHHVPNATLESSAGAELSFILPRESTH---RFEGL 809
TL K+ C+ ++ ++ H+P A L+ G EL ++LP ST + L
Sbjct: 1257 TLTKKKSPNLNANAVCDTMAVTAMIQSHLPEAYLKEDIGGELVYVLPPFSTKVSGAYLSL 1316
Query: 810 FAKLEKKQKELGIASFGASITTMEEVFLRVGKLVDSSMDIQAIQLPALQYQHERRASDWA 869
L+ +L I +G S TT+EEVFL + K + Q +L++ +++
Sbjct: 1317 LRALDNGMGDLNIGCYGISDTTVEEVFLNLTK------ESQKNSAMSLEHLTQKKIG--- 1367
Query: 870 VDSNLCGAMDPSD-GIGALIEEER-----TAVKLNTGLALHCQQFWAMFLKKAAYSWREW 923
+SN G P D + + +R T + G L ++ A+ +K+ ++ R W
Sbjct: 1368 -NSNANGISTPDDLSVSSSNFTDRDDKILTRGERLDGFGLLLKKIMAILIKRFHHTRRNW 1426
Query: 924 KMVAAQVLVPLTCVTLAL 941
K + AQV++P+ VT A+
Sbjct: 1427 KGLIAQVILPIVFVTTAM 1444
Score = 363 bits (933), Expect = e-100
Identities = 217/671 (32%), Positives = 361/671 (53%), Gaps = 38/671 (5%)
Query: 1035 RTVVNALFNNQAYHSPATALAVVDNLLFKLLCGPHAS----IVVSNFPQPRSALQAAKDQ 1090
RT+ ++ + YHS L ++N L ++ + + I++ + P P +Q +
Sbjct: 1604 RTLAKVWYDPEGYHSLPAYLNSLNNFLLRVNMSKYDAARHGIIMYSHPYP--GVQDQEQA 1661
Query: 1091 FNEGRKGFDIALNLLFAMAFLASTFSILAVSERAVQAKHVQFVSGVHVASFWLSALLWDL 1150
+AL++L + ++F V E +AK +Q +SG+ V +W++ ++D+
Sbjct: 1662 TISSLIDILVALSILMGYSVTTASFVTYVVREHQTKAKQLQHISGIGVTCYWVTNFIYDM 1721
Query: 1151 ISFLIPSLLLLVVFKAFDVRAFTRDGHMADTLLLLLLYGWAIIPLMYLMNFFFLGAATAY 1210
+ +L+P + + F + AF + ++ LLLLL+G+A MYL+ F A+
Sbjct: 1722 VFYLVPVAFSIGIIAIFKLPAFYSENNLGAVSLLLLLFGYATFSWMYLLAGLFHETGMAF 1781
Query: 1211 TRLTIFNILSGIATFLMVTIMRIPAVK------LEELSKTLDHVFLVLPNHCLGMAVSSF 1264
N+ GI + + ++++ + + LE +S+TL +FL+ P C G +
Sbjct: 1782 ITYVCVNLFFGINSIVSLSVVYFLSKEKPNDPTLELISETLKRIFLIFPQFCFGYGLIEL 1841
Query: 1265 YENYETRRYCTSSEVAAHYCKKYNIQYQENFYAWSAPGVGRFVASMAASGCAYLILLFLI 1324
+ + + K Y ++Y + + +G ++ + G + L LI
Sbjct: 1842 ----------SQQQSVLDFLKAYGVEYPNETFEMNK--LGAMFVALVSQGTMFFSLRLLI 1889
Query: 1325 ETNLLQRLRGILCALRRRRTLTELYTRMPVLPEDQDVADERTRILAPSPD-SLLHTPLII 1383
+L+++LR R + R + ED+DV ER R+ + + + L+ +
Sbjct: 1890 NESLIKKLRLFF------RKFNSSHVR-ETIDEDEDVRAERLRVESGAAEFDLVQLYCLT 1942
Query: 1384 KELSKVYEQRVPLLAVDRLSLAVQKGECFGLLGFNGAGKTTTFKMLTGEESLTSGDAFVG 1443
K ++++ ++AV+ +S+ + GECFGLLG NGAGKTT FKMLTG+ +SG+ +
Sbjct: 1943 KTYQLIHKK---IIAVNNISIGIPAGECFGLLGVNGAGKTTIFKMLTGDIIPSSGNILIR 1999
Query: 1444 GHRIS-SDVGKVRQRIGYCPQFDALLDHMTGREMLVMYARLRGIPERHIGACVENTLRGL 1502
S V +GYCPQ DAL D +T E L YAR+ GIPE+ I V LR L
Sbjct: 2000 NKTGSLGHVDSHSSLVGYCPQEDALDDLVTVEEHLYFYARVHGIPEKDIKETVHKLLRRL 2059
Query: 1503 LLEPHANKLVRTYSGGNKRKLSTGIALIGEPAVIFLDEPSTGMDPVARRLLWDTVARARE 1562
L P ++ S G KRKLST +ALIG+P+++ LDEPS+GMDP ++R LW ++ +
Sbjct: 2060 HLMPFKDRATSMCSYGTKRKLSTALALIGKPSILLLDEPSSGMDPKSKRHLWKIISEEVQ 2119
Query: 1563 SGKAIIITSHSMEECEALCTRLAIMVQGQFKCLGSPQHLKSKFGSGYSLRAKVQSEGQQE 1622
+ ++I+TSHSMEECEALCTRLAIMV G+F+C+GS QH+KS+FG G+++ KV + +
Sbjct: 2120 NKCSVILTSHSMEECEALCTRLAIMVNGKFQCIGSLQHIKSRFGRGFTV--KVHLKNNKV 2177
Query: 1623 ALEEFKAFVDLTFPGSVLEDEHQGMVHYHLPGRDLSWAKVFGILEKAKEKYGVDDYSVSQ 1682
+E F+ L FP + L+D+H M+ YH+P A +F +LE K + ++ VSQ
Sbjct: 2178 TMETLTKFMQLHFPKTYLKDQHLSMLEYHVPVTAGGVANIFDLLETNKTALNITNFLVSQ 2237
Query: 1683 ISLEQVFLSFA 1693
+LE+VF++FA
Sbjct: 2238 TTLEEVFINFA 2248
Score = 196 bits (499), Expect = 1e-49
Identities = 170/600 (28%), Positives = 282/600 (47%), Gaps = 34/600 (5%)
Query: 259 IQYQLPLLLLLSFTYTALTIARAVVQEKERRLKEYMRMMGLSSWLHWSAWFLLFFLFLLI 318
I + L +L+ ++ T + VV+E + + K+ + G+ +W F+ +F L+
Sbjct: 1667 IDILVALSILMGYSVTTASFVTYVVREHQTKAKQLQHISGIGVTCYWVTNFIYDMVFYLV 1726
Query: 319 AASFMTLLFCVKVKPNVAVLSRSDPSLVLAFLLCFAISTISFSFMVSTFFSKANMAAA-- 376
+F + + P A S ++ V LL F +T S+ ++++ F + MA
Sbjct: 1727 PVAFSIGIIAIFKLP--AFYSENNLGAVSLLLLLFGYATFSWMYLLAGLFHETGMAFITY 1784
Query: 377 ------FGGFLYFFTYIPYFFVAPRYNWMTL---SQKLCSCLLSNVAMAMGAQLIGKFEA 427
FG + YF + N TL S+ L L G LI +
Sbjct: 1785 VCVNLFFGINSIVSLSVVYFLSKEKPNDPTLELISETLKRIFLIFPQFCFGYGLIELSQQ 1844
Query: 428 KGMGIQWRDLLSPVNVD---DDFCFGQVLGMLLLDSVLYGLVTWYMEAVFPGQFGVPQPW 484
+ + D L V+ + F + LG + + V G + + + +
Sbjct: 1845 QSV----LDFLKAYGVEYPNETFEMNK-LGAMFVALVSQGTMFFSLRLLINESLIKKLRL 1899
Query: 485 YFFIMPSYWCGKPRAVAGKEEEDSDPEKALRNEYFEAEPEDLVAGIKIKHLSKVFRVGNK 544
+F S + E+ED E+ LR E AE DLV ++ L+K +++ +K
Sbjct: 1900 FFRKFNSSHVRETI----DEDEDVRAER-LRVESGAAE-FDLV---QLYCLTKTYQLIHK 1950
Query: 545 DRAAVRDLNLNLYEGQITVLLGHNGAGKTTTLSMLTGLFPPTSGRAYISGYEISQDMVQI 604
AV ++++ + G+ LLG NGAGKTT MLTG P+SG I S V
Sbjct: 1951 KIIAVNNISIGIPAGECFGLLGVNGAGKTTIFKMLTGDIIPSSGNILIRNKTGSLGHVDS 2010
Query: 605 RKSL-GLCPQHDILFDNLTVAEHLYFYAQLKGLSRQKCPEEVKQMLHIIGLEDKWNSRSR 663
SL G CPQ D L D +TV EHLYFYA++ G+ + E V ++L + L + +
Sbjct: 2011 HSSLVGYCPQEDALDDLVTVEEHLYFYARVHGIPEKDIKETVHKLLRRLHLMPFKDRATS 2070
Query: 664 FLSGGMRRKLSIGIALIAGSKVLILDEPTSGMDAISRRAIWDLLQRQKSDR-TIVLTTHF 722
S G +RKLS +ALI +L+LDEP+SGMD S+R +W ++ + ++ +++LT+H
Sbjct: 2071 MCSYGTKRKLSTALALIGKPSILLLDEPSSGMDPKSKRHLWKIISEEVQNKCSVILTSHS 2130
Query: 723 MDEADLLGDRIAIMAKGELQCCGSSLFLKQKYGAGYHMTL-VKEPHCNPEDISQLVHHHV 781
M+E + L R+AIM G+ QC GS +K ++G G+ + + +K E +++ + H
Sbjct: 2131 MEECEALCTRLAIMVNGKFQCIGSLQHIKSRFGRGFTVKVHLKNNKVTMETLTKFMQLHF 2190
Query: 782 PNATLESSAGAELSFILPRESTHRFEGLFAKLEKKQKELGIASFGASITTMEEVFLRVGK 841
P L+ + L + +P + +F LE + L I +F S TT+EEVF+ K
Sbjct: 2191 PKTYLKDQHLSMLEYHVP-VTAGGVANIFDLLETNKTALNITNFLVSQTTLEEVFINFAK 2249
Score = 191 bits (484), Expect = 7e-48
Identities = 162/626 (25%), Positives = 292/626 (46%), Gaps = 61/626 (9%)
Query: 1098 FDIALNLLFAMAFLASTFSILAVSERAVQAKHVQFVSGVHVASFWLSALLWDLISFLIPS 1157
+ + + L+ A + F V E+ ++ + GV+ S + + L+ + + FL+ +
Sbjct: 749 YSLPIVLMVAWVVFIAAFVKKLVYEKDLRLHEYMKMMGVNSCSHFFAWLI-ESVGFLLVT 807
Query: 1158 LLLLVVFKAFDVRAFTRDGHMADTLLLLLLYGWAIIPLMYLMNFFFLGAATAYTRLTIFN 1217
+++L++ F +G + L Y +++I + YL++ FF A ++
Sbjct: 808 IVILIIILKFGNILPKTNGFIL--FLYFSDYSFSVIAMSYLISVFFNNTNIAALIGSLIY 865
Query: 1218 ILSGIATFLMVTIMRIPAVKLEELSKTLDHVFLVLPNHCLGMAVSSFYENYETRRYCTSS 1277
I++ ++VT+ ELS L VF+ L + S + YE +
Sbjct: 866 IIAFFPFIVLVTVEN-------ELSYVLK-VFMSLLSPTAFSYASQYIARYEEQG----- 912
Query: 1278 EVAAHYCKKYNIQYQENFYAWSAPGVGRFVASMAASGCAYLILLFLIETNLLQRLRGIL- 1336
+ + Y Q++ ++ G + A Y ++ + + N+ G+
Sbjct: 913 -IGLQWENMYTSPVQDDTTSF-----GWLCCLILADSFIYFLIAWYVR-NVFPGTYGMAA 965
Query: 1337 ----------------CA-LRRRRTLTELYTRMPVLPEDQDVADER--TRILAPSPDSLL 1377
CA ++ ++ ++T + + + + E + + P P L
Sbjct: 966 PWYFPILPSYWKERFGCAEVKPEKSNGLMFTNIMMQNTNPSASPEYMFSSNIEPEPKDLT 1025
Query: 1378 HTPLIIKELSKVYEQRVPLLAVDRLSLAVQKGECFGLLGFNGAGKTTTFKMLTGEESLTS 1437
+ + ++K+Y +V AVD L+L +G LLG NGAGKTTT MLTG ++
Sbjct: 1026 -VGVALHGVTKIYGSKV---AVDNLNLNFYEGHITSLLGPNGAGKTTTISMLTGLFGASA 1081
Query: 1438 GDAFVGGHRISSDVGKVRQRIGYCPQFDALLDHMTGREMLVMYARLRGIP---ERHIGAC 1494
G FV G I +D+ VR+ +G C Q D L ++T +E L++Y ++ +P ++ +
Sbjct: 1082 GTIFVYGKDIKTDLHTVRKNMGVCMQHDVLFSYLTTKEHLLLYGSIK-VPHWTKKQLHEE 1140
Query: 1495 VENTLRGLLLEPHANKLVRTYSGGNKRKLSTGIALIGEPAVIFLDEPSTGMDPVARRLLW 1554
V+ TL+ L H +K V T SGG KRKLS IALIG V+ LDEPSTG+DP +RR +W
Sbjct: 1141 VKRTLKDTGLYSHRHKRVGTLSGGMKRKLSISIALIGGSRVVILDEPSTGVDPCSRRSIW 1200
Query: 1555 DTVARARESGKAIIITSHSMEECEALCTRLAIMVQGQFKCLGSPQHLKSKFGSGYSLRAK 1614
D +++ ++ + II+++H ++E E L R+A + QG +C GSP +LK FG GY L
Sbjct: 1201 DVISK-NKTARTIILSTHHLDEAEVLSDRIAFLEQGGLRCCGSPFYLKEAFGDGYHLTLT 1259
Query: 1615 VQSEGQQEA-----LEEFKAFVDLTFPGSVLEDEHQGMVHYHLPGRDL----SWAKVFGI 1665
+ A A + P + L+++ G + Y LP ++ +
Sbjct: 1260 KKKSPNLNANAVCDTMAVTAMIQSHLPEAYLKEDIGGELVYVLPPFSTKVSGAYLSLLRA 1319
Query: 1666 LEKAKEKYGVDDYSVSQISLEQVFLS 1691
L+ + Y +S ++E+VFL+
Sbjct: 1320 LDNGMGDLNIGCYGISDTTVEEVFLN 1345
>gi|30795238 ATP-binding cassette, sub-family A, member 12 isoform a
[Homo sapiens]
Length = 2595
Score = 476 bits (1225), Expect = e-134
Identities = 292/858 (34%), Positives = 469/858 (54%), Gaps = 86/858 (10%)
Query: 126 SSSVLAAVVFEHPFNHSKEP--------LPLAVKYHLRFSYTRRNYMWTQTGSFFLKETE 177
S+ + +V+F+ P N S LP +KY +R S LK +
Sbjct: 949 SNELFGSVIFKLPSNRSWHRGYDSGNVFLPPVIKYTIRMS---------------LKTAQ 993
Query: 178 GWHTTSLFPLFPNPGPREPTSPDGGEPGYIREGFLAVQHAVDRAIMEYHADAATRQLFQR 237
T SL PGP SP + F+ +Q +++RAI+E T + Q
Sbjct: 994 T--TRSLRTKIWAPGPHN--SPSHNQ--IYGRAFIYLQDSIERAIIELQ----TGRNSQE 1043
Query: 238 LTVTIKRFPYPPFIADPFLVAIQYQLPLLLLLSFTYTALTIARAVVQEKERRLKEYMRMM 297
+ V ++ PYP F+ D FL ++ Y LP++L++++ + +V EK+ RL EYM+MM
Sbjct: 1044 IAVQVQAIPYPCFMKDNFLTSVSYSLPIVLMVAWVVFIAAFVKKLVYEKDLRLHEYMKMM 1103
Query: 298 GLSSWLHWSAWFLLFFLFLLIAASFMTLLFCVKVKPNVAVLSRSDPSLVLAFLLCFAIST 357
G++S H+ AW + FLL+ T++ + + +L +++ ++ + ++ S
Sbjct: 1104 GVNSCSHFFAWLIESVGFLLV-----TIVILIIILKFGNILPKTNGFILFLYFSDYSFSV 1158
Query: 358 ISFSFMVSTFFSKANMAAAFGGFLYFFTYIPYFFVAPRYNWMTLSQKLCSCLLSNVAMAM 417
I+ S+++S FF+ N+AA G +Y + P+ + N ++ K+ LLS A +
Sbjct: 1159 IAMSYLISVFFNNTNIAALIGSLIYIIAFFPFIVLVTVENELSYVLKVFMSLLSPTAFSY 1218
Query: 418 GAQLIGKFEAKGMGIQWRDLLSPVNVDDDFCFGQVLGMLLLDSVLYGLVTWYMEAVFPGQ 477
+Q I ++E +G+G+QW ++ + DD FG + ++L DS +Y L+ WY+ VFPG
Sbjct: 1219 ASQYIARYEEQGIGLQWENMYTSPVQDDTTSFGWLCCLILADSFIYFLIAWYVRNVFPGT 1278
Query: 478 FGVPQPWYFFIMPSYW-----CG--KPRAVAG--------KEEEDSDPEKALRNEYFEAE 522
+G+ PWYF I+PSYW C KP G + S + + + E E
Sbjct: 1279 YGMAAPWYFPILPSYWKERFGCAEVKPEKSNGLMFTNIMMQNTNPSASPEYMFSSNIEPE 1338
Query: 523 PEDLVAGIKIKHLSKVFRVGNKDRAAVRDLNLNLYEGQITVLLGHNGAGKTTTLSMLTGL 582
P+DL G+ + ++K++ G+K AV +LNLN YEG IT LLG NGAGKTTT+SMLTGL
Sbjct: 1339 PKDLTVGVALHGVTKIY--GSK--VAVDNLNLNFYEGHITSLLGPNGAGKTTTISMLTGL 1394
Query: 583 FPPTSGRAYISGYEISQDMVQIRKSLGLCPQHDILFDNLTVAEHLYFYAQLK--GLSRQK 640
F ++G ++ G +I D+ +RK++G+C QHD+LF LT EHL Y +K ++++
Sbjct: 1395 FGASAGTIFVYGKDIKTDLHTVRKNMGVCMQHDVLFSYLTTKEHLLLYGSIKVPHWTKKQ 1454
Query: 641 CPEEVKQMLHIIGLEDKWNSRSRFLSGGMRRKLSIGIALIAGSKVLILDEPTSGMDAISR 700
EEVK+ L GL + R LSGGM+RKLSI IALI GS+V+ILDEP++G+D SR
Sbjct: 1455 LHEEVKRTLKDTGLYSHRHKRVGTLSGGMKRKLSISIALIGGSRVVILDEPSTGVDPCSR 1514
Query: 701 RAIWDLLQRQKSDRTIVLTTHFMDEADLLGDRIAIMAKGELQCCGSSLFLKQKYGAGYHM 760
R+IWD++ + K+ RTI+L+TH +DEA++L DRIA + +G L+CCGS +LK+ +G GYH+
Sbjct: 1515 RSIWDVISKNKTARTIILSTHHLDEAEVLSDRIAFLEQGGLRCCGSPFYLKEAFGDGYHL 1574
Query: 761 TLVKEPH--------CNPEDISQLVHHHVPNATLESSAGAELSFILPRESTH---RFEGL 809
TL K+ C+ ++ ++ H+P A L+ G EL ++LP ST + L
Sbjct: 1575 TLTKKKSPNLNANAVCDTMAVTAMIQSHLPEAYLKEDIGGELVYVLPPFSTKVSGAYLSL 1634
Query: 810 FAKLEKKQKELGIASFGASITTMEEVFLRVGKLVDSSMDIQAIQLPALQYQHERRASDWA 869
L+ +L I +G S TT+EEVFL + K + Q +L++ +++
Sbjct: 1635 LRALDNGMGDLNIGCYGISDTTVEEVFLNLTK------ESQKNSAMSLEHLTQKKIG--- 1685
Query: 870 VDSNLCGAMDPSD-GIGALIEEER-----TAVKLNTGLALHCQQFWAMFLKKAAYSWREW 923
+SN G P D + + +R T + G L ++ A+ +K+ ++ R W
Sbjct: 1686 -NSNANGISTPDDLSVSSSNFTDRDDKILTRGERLDGFGLLLKKIMAILIKRFHHTRRNW 1744
Query: 924 KMVAAQVLVPLTCVTLAL 941
K + AQV++P+ VT A+
Sbjct: 1745 KGLIAQVILPIVFVTTAM 1762
Score = 363 bits (933), Expect = e-100
Identities = 217/671 (32%), Positives = 361/671 (53%), Gaps = 38/671 (5%)
Query: 1035 RTVVNALFNNQAYHSPATALAVVDNLLFKLLCGPHAS----IVVSNFPQPRSALQAAKDQ 1090
RT+ ++ + YHS L ++N L ++ + + I++ + P P +Q +
Sbjct: 1922 RTLAKVWYDPEGYHSLPAYLNSLNNFLLRVNMSKYDAARHGIIMYSHPYP--GVQDQEQA 1979
Query: 1091 FNEGRKGFDIALNLLFAMAFLASTFSILAVSERAVQAKHVQFVSGVHVASFWLSALLWDL 1150
+AL++L + ++F V E +AK +Q +SG+ V +W++ ++D+
Sbjct: 1980 TISSLIDILVALSILMGYSVTTASFVTYVVREHQTKAKQLQHISGIGVTCYWVTNFIYDM 2039
Query: 1151 ISFLIPSLLLLVVFKAFDVRAFTRDGHMADTLLLLLLYGWAIIPLMYLMNFFFLGAATAY 1210
+ +L+P + + F + AF + ++ LLLLL+G+A MYL+ F A+
Sbjct: 2040 VFYLVPVAFSIGIIAIFKLPAFYSENNLGAVSLLLLLFGYATFSWMYLLAGLFHETGMAF 2099
Query: 1211 TRLTIFNILSGIATFLMVTIMRIPAVK------LEELSKTLDHVFLVLPNHCLGMAVSSF 1264
N+ GI + + ++++ + + LE +S+TL +FL+ P C G +
Sbjct: 2100 ITYVCVNLFFGINSIVSLSVVYFLSKEKPNDPTLELISETLKRIFLIFPQFCFGYGLIEL 2159
Query: 1265 YENYETRRYCTSSEVAAHYCKKYNIQYQENFYAWSAPGVGRFVASMAASGCAYLILLFLI 1324
+ + + K Y ++Y + + +G ++ + G + L LI
Sbjct: 2160 ----------SQQQSVLDFLKAYGVEYPNETFEMNK--LGAMFVALVSQGTMFFSLRLLI 2207
Query: 1325 ETNLLQRLRGILCALRRRRTLTELYTRMPVLPEDQDVADERTRILAPSPD-SLLHTPLII 1383
+L+++LR R + R + ED+DV ER R+ + + + L+ +
Sbjct: 2208 NESLIKKLRLFF------RKFNSSHVR-ETIDEDEDVRAERLRVESGAAEFDLVQLYCLT 2260
Query: 1384 KELSKVYEQRVPLLAVDRLSLAVQKGECFGLLGFNGAGKTTTFKMLTGEESLTSGDAFVG 1443
K ++++ ++AV+ +S+ + GECFGLLG NGAGKTT FKMLTG+ +SG+ +
Sbjct: 2261 KTYQLIHKK---IIAVNNISIGIPAGECFGLLGVNGAGKTTIFKMLTGDIIPSSGNILIR 2317
Query: 1444 GHRIS-SDVGKVRQRIGYCPQFDALLDHMTGREMLVMYARLRGIPERHIGACVENTLRGL 1502
S V +GYCPQ DAL D +T E L YAR+ GIPE+ I V LR L
Sbjct: 2318 NKTGSLGHVDSHSSLVGYCPQEDALDDLVTVEEHLYFYARVHGIPEKDIKETVHKLLRRL 2377
Query: 1503 LLEPHANKLVRTYSGGNKRKLSTGIALIGEPAVIFLDEPSTGMDPVARRLLWDTVARARE 1562
L P ++ S G KRKLST +ALIG+P+++ LDEPS+GMDP ++R LW ++ +
Sbjct: 2378 HLMPFKDRATSMCSYGTKRKLSTALALIGKPSILLLDEPSSGMDPKSKRHLWKIISEEVQ 2437
Query: 1563 SGKAIIITSHSMEECEALCTRLAIMVQGQFKCLGSPQHLKSKFGSGYSLRAKVQSEGQQE 1622
+ ++I+TSHSMEECEALCTRLAIMV G+F+C+GS QH+KS+FG G+++ KV + +
Sbjct: 2438 NKCSVILTSHSMEECEALCTRLAIMVNGKFQCIGSLQHIKSRFGRGFTV--KVHLKNNKV 2495
Query: 1623 ALEEFKAFVDLTFPGSVLEDEHQGMVHYHLPGRDLSWAKVFGILEKAKEKYGVDDYSVSQ 1682
+E F+ L FP + L+D+H M+ YH+P A +F +LE K + ++ VSQ
Sbjct: 2496 TMETLTKFMQLHFPKTYLKDQHLSMLEYHVPVTAGGVANIFDLLETNKTALNITNFLVSQ 2555
Query: 1683 ISLEQVFLSFA 1693
+LE+VF++FA
Sbjct: 2556 TTLEEVFINFA 2566
Score = 196 bits (499), Expect = 1e-49
Identities = 170/600 (28%), Positives = 282/600 (47%), Gaps = 34/600 (5%)
Query: 259 IQYQLPLLLLLSFTYTALTIARAVVQEKERRLKEYMRMMGLSSWLHWSAWFLLFFLFLLI 318
I + L +L+ ++ T + VV+E + + K+ + G+ +W F+ +F L+
Sbjct: 1985 IDILVALSILMGYSVTTASFVTYVVREHQTKAKQLQHISGIGVTCYWVTNFIYDMVFYLV 2044
Query: 319 AASFMTLLFCVKVKPNVAVLSRSDPSLVLAFLLCFAISTISFSFMVSTFFSKANMAAA-- 376
+F + + P A S ++ V LL F +T S+ ++++ F + MA
Sbjct: 2045 PVAFSIGIIAIFKLP--AFYSENNLGAVSLLLLLFGYATFSWMYLLAGLFHETGMAFITY 2102
Query: 377 ------FGGFLYFFTYIPYFFVAPRYNWMTL---SQKLCSCLLSNVAMAMGAQLIGKFEA 427
FG + YF + N TL S+ L L G LI +
Sbjct: 2103 VCVNLFFGINSIVSLSVVYFLSKEKPNDPTLELISETLKRIFLIFPQFCFGYGLIELSQQ 2162
Query: 428 KGMGIQWRDLLSPVNVD---DDFCFGQVLGMLLLDSVLYGLVTWYMEAVFPGQFGVPQPW 484
+ + D L V+ + F + LG + + V G + + + +
Sbjct: 2163 QSV----LDFLKAYGVEYPNETFEMNK-LGAMFVALVSQGTMFFSLRLLINESLIKKLRL 2217
Query: 485 YFFIMPSYWCGKPRAVAGKEEEDSDPEKALRNEYFEAEPEDLVAGIKIKHLSKVFRVGNK 544
+F S + E+ED E+ LR E AE DLV ++ L+K +++ +K
Sbjct: 2218 FFRKFNSSHVRETI----DEDEDVRAER-LRVESGAAE-FDLV---QLYCLTKTYQLIHK 2268
Query: 545 DRAAVRDLNLNLYEGQITVLLGHNGAGKTTTLSMLTGLFPPTSGRAYISGYEISQDMVQI 604
AV ++++ + G+ LLG NGAGKTT MLTG P+SG I S V
Sbjct: 2269 KIIAVNNISIGIPAGECFGLLGVNGAGKTTIFKMLTGDIIPSSGNILIRNKTGSLGHVDS 2328
Query: 605 RKSL-GLCPQHDILFDNLTVAEHLYFYAQLKGLSRQKCPEEVKQMLHIIGLEDKWNSRSR 663
SL G CPQ D L D +TV EHLYFYA++ G+ + E V ++L + L + +
Sbjct: 2329 HSSLVGYCPQEDALDDLVTVEEHLYFYARVHGIPEKDIKETVHKLLRRLHLMPFKDRATS 2388
Query: 664 FLSGGMRRKLSIGIALIAGSKVLILDEPTSGMDAISRRAIWDLLQRQKSDR-TIVLTTHF 722
S G +RKLS +ALI +L+LDEP+SGMD S+R +W ++ + ++ +++LT+H
Sbjct: 2389 MCSYGTKRKLSTALALIGKPSILLLDEPSSGMDPKSKRHLWKIISEEVQNKCSVILTSHS 2448
Query: 723 MDEADLLGDRIAIMAKGELQCCGSSLFLKQKYGAGYHMTL-VKEPHCNPEDISQLVHHHV 781
M+E + L R+AIM G+ QC GS +K ++G G+ + + +K E +++ + H
Sbjct: 2449 MEECEALCTRLAIMVNGKFQCIGSLQHIKSRFGRGFTVKVHLKNNKVTMETLTKFMQLHF 2508
Query: 782 PNATLESSAGAELSFILPRESTHRFEGLFAKLEKKQKELGIASFGASITTMEEVFLRVGK 841
P L+ + L + +P + +F LE + L I +F S TT+EEVF+ K
Sbjct: 2509 PKTYLKDQHLSMLEYHVP-VTAGGVANIFDLLETNKTALNITNFLVSQTTLEEVFINFAK 2567
Score = 191 bits (484), Expect = 7e-48
Identities = 162/626 (25%), Positives = 292/626 (46%), Gaps = 61/626 (9%)
Query: 1098 FDIALNLLFAMAFLASTFSILAVSERAVQAKHVQFVSGVHVASFWLSALLWDLISFLIPS 1157
+ + + L+ A + F V E+ ++ + GV+ S + + L+ + + FL+ +
Sbjct: 1067 YSLPIVLMVAWVVFIAAFVKKLVYEKDLRLHEYMKMMGVNSCSHFFAWLI-ESVGFLLVT 1125
Query: 1158 LLLLVVFKAFDVRAFTRDGHMADTLLLLLLYGWAIIPLMYLMNFFFLGAATAYTRLTIFN 1217
+++L++ F +G + L Y +++I + YL++ FF A ++
Sbjct: 1126 IVILIIILKFGNILPKTNGFIL--FLYFSDYSFSVIAMSYLISVFFNNTNIAALIGSLIY 1183
Query: 1218 ILSGIATFLMVTIMRIPAVKLEELSKTLDHVFLVLPNHCLGMAVSSFYENYETRRYCTSS 1277
I++ ++VT+ ELS L VF+ L + S + YE +
Sbjct: 1184 IIAFFPFIVLVTVEN-------ELSYVLK-VFMSLLSPTAFSYASQYIARYEEQG----- 1230
Query: 1278 EVAAHYCKKYNIQYQENFYAWSAPGVGRFVASMAASGCAYLILLFLIETNLLQRLRGIL- 1336
+ + Y Q++ ++ G + A Y ++ + + N+ G+
Sbjct: 1231 -IGLQWENMYTSPVQDDTTSF-----GWLCCLILADSFIYFLIAWYVR-NVFPGTYGMAA 1283
Query: 1337 ----------------CA-LRRRRTLTELYTRMPVLPEDQDVADER--TRILAPSPDSLL 1377
CA ++ ++ ++T + + + + E + + P P L
Sbjct: 1284 PWYFPILPSYWKERFGCAEVKPEKSNGLMFTNIMMQNTNPSASPEYMFSSNIEPEPKDLT 1343
Query: 1378 HTPLIIKELSKVYEQRVPLLAVDRLSLAVQKGECFGLLGFNGAGKTTTFKMLTGEESLTS 1437
+ + ++K+Y +V AVD L+L +G LLG NGAGKTTT MLTG ++
Sbjct: 1344 -VGVALHGVTKIYGSKV---AVDNLNLNFYEGHITSLLGPNGAGKTTTISMLTGLFGASA 1399
Query: 1438 GDAFVGGHRISSDVGKVRQRIGYCPQFDALLDHMTGREMLVMYARLRGIP---ERHIGAC 1494
G FV G I +D+ VR+ +G C Q D L ++T +E L++Y ++ +P ++ +
Sbjct: 1400 GTIFVYGKDIKTDLHTVRKNMGVCMQHDVLFSYLTTKEHLLLYGSIK-VPHWTKKQLHEE 1458
Query: 1495 VENTLRGLLLEPHANKLVRTYSGGNKRKLSTGIALIGEPAVIFLDEPSTGMDPVARRLLW 1554
V+ TL+ L H +K V T SGG KRKLS IALIG V+ LDEPSTG+DP +RR +W
Sbjct: 1459 VKRTLKDTGLYSHRHKRVGTLSGGMKRKLSISIALIGGSRVVILDEPSTGVDPCSRRSIW 1518
Query: 1555 DTVARARESGKAIIITSHSMEECEALCTRLAIMVQGQFKCLGSPQHLKSKFGSGYSLRAK 1614
D +++ ++ + II+++H ++E E L R+A + QG +C GSP +LK FG GY L
Sbjct: 1519 DVISK-NKTARTIILSTHHLDEAEVLSDRIAFLEQGGLRCCGSPFYLKEAFGDGYHLTLT 1577
Query: 1615 VQSEGQQEA-----LEEFKAFVDLTFPGSVLEDEHQGMVHYHLPGRDL----SWAKVFGI 1665
+ A A + P + L+++ G + Y LP ++ +
Sbjct: 1578 KKKSPNLNANAVCDTMAVTAMIQSHLPEAYLKEDIGGELVYVLPPFSTKVSGAYLSLLRA 1637
Query: 1666 LEKAKEKYGVDDYSVSQISLEQVFLS 1691
L+ + Y +S ++E+VFL+
Sbjct: 1638 LDNGMGDLNIGCYGISDTTVEEVFLN 1663
Score = 31.6 bits (70), Expect = 6.9
Identities = 21/71 (29%), Positives = 34/71 (47%), Gaps = 4/71 (5%)
Query: 2 AVLRQLALLLWKNYTLQKRKVLVTVLELFLPLLFSGILIWLRLKIQSENVPNATIYPGQS 61
++ QL +L+WKN+ KR+ L T++ + P++ IL R K P + P
Sbjct: 3 SLFHQLQILVWKNWLGVKRQPLWTLVLILWPVIIFIILAITRTKFPPTAKPTCYLAP--- 59
Query: 62 IQELPLFFTFP 72
+ LP FP
Sbjct: 60 -RNLPSTGFFP 69
>gi|31657092 ATP binding cassette, sub-family A (ABC1), member 13
[Homo sapiens]
Length = 5058
Score = 424 bits (1090), Expect = e-118
Identities = 268/800 (33%), Positives = 421/800 (52%), Gaps = 58/800 (7%)
Query: 200 DGGEPGYIREGFLAVQHAVDRAIMEYHADAATRQLFQRLTVTIKRFPYPPFIADPFLVAI 259
DG + Y+ F +Q ++RAI+ T Q + PYP +D FL +
Sbjct: 3516 DGFKYNYV---FAPLQDMIERAIILVQ----TGQEALEPAAQTQAAPYPCHTSDLFLNNV 3568
Query: 260 QYQLPLLLLLSFTYTALTIARAVVQEKERRLKEYMRMMGLSSWLHWSAWFLLFFLFLLIA 319
+ PL+++L++ + ++ R +V E+E +++EYMRMMG+ +H+ AWFL L I+
Sbjct: 3569 GFFFPLIMMLTWMVSVASMVRKLVYEQEIQIEEYMRMMGVHPVIHFLAWFLENMAVLTIS 3628
Query: 320 ASFMTLLFCVKVKPNVAVLSRSDPSLVLAFLLCFAISTISFSFMVSTFFSKANMAAAFGG 379
++ TL +K + + S+ +V FLL F +S + S+++S FFS+AN AA
Sbjct: 3629 SA--TLAIVLKTS---GIFAHSNTFIVFLFLLDFGMSVVMLSYLLSAFFSQANTAALCTS 3683
Query: 380 FLYFFTYIPYFFVAPRYNWMTLSQKLCSCLLSNVAMAMGAQLIGKFEAKGMGIQWRDLLS 439
+Y +++PY + +N ++ + CLLS A G I E + GIQW ++
Sbjct: 3684 LVYMISFLPYIVLLVLHNQLSFVNQTFLCLLSTTAFGQGVFFITFLEGQETGIQWNNMYQ 3743
Query: 440 PVNVDDDFCFGQVLGMLLLDSVLYGLVTWYMEAVFPGQFGVPQPWYFFIMPSYWCGKPRA 499
+ FG V M+L DS LY L WY+ + PG FG+ +PWYF SYW
Sbjct: 3744 ALE-QGGMTFGWVCWMILFDSSLYFLCGWYLSNLIPGTFGLRKPWYFPFTASYWKSVGFL 3802
Query: 500 VAGKE-----------EEDSDPEKALRNEYFEAEPEDLVAGIKIKHLSKVFRVGNKDRAA 548
V ++ E + +L+N E E E G+ + ++K + G+K A
Sbjct: 3803 VEKRQYFLSSSLFFFNENFDNKGSSLQNR--EGELEGSAPGVTLVSVTKEYE-GHK--AV 3857
Query: 549 VRDLNLNLYEGQITVLLGHNGAGKTTTLSMLTGLFPPTSGRAYISGYEISQDMVQIRKSL 608
V+DL+L Y QIT LLG NGAGKTT +SMLTGL PPTSG I+G + D+ ++R L
Sbjct: 3858 VQDLSLTFYRDQITALLGTNGAGKTTIISMLTGLHPPTSGTIIINGKNLQTDLSRVRMEL 3917
Query: 609 GLCPQHDILFDNLTVAEHLYFYAQLKG--LSRQKCPEEVKQMLHIIGLEDKWNSRSRFLS 666
G+CPQ DIL DNLTV EHL +A +K ++++ ++V Q L + L + ++R LS
Sbjct: 3918 GVCPQQDILLDNLTVREHLLLFASIKAPQWTKKELHQQVNQTLQDVDLTQHQHKQTRALS 3977
Query: 667 GGMRRKLSIGIALIAGSKVLILDEPTSGMDAISRRAIWDLLQRQKSDRTIVLTTHFMDEA 726
GG++RKLS+GIA + S+ ++LDEPTSG+D SR ++WD+L + + RTI+ TTH +DEA
Sbjct: 3978 GGLKRKLSLGIAFMGMSRTVVLDEPTSGVDPCSRHSLWDILLKYREGRTIIFTTHHLDEA 4037
Query: 727 DLLGDRIAIMAKGELQCCGSSLFLKQKYGAGYHMTLVKEPHC-------NPEDISQLVHH 779
+ L DR+A++ G L+CCG LK+ YG G +TL ++P + ++ L+
Sbjct: 4038 EALSDRVAVLQHGRLRCCGPPFCLKEAYGQGLRLTLTRQPSVLEAHDLKDMACVTSLIKI 4097
Query: 780 HVPNATLESSAGAELSFILPRESTHR-FEGLFAKLEKKQKELGIASFGASITTMEEVFLR 838
++P A L+ S+G+EL++ +P+++ +GLF L++ +L + +G S TT+EEVFL
Sbjct: 4098 YIPQAFLKDSSGSELTYTIPKDTDKACLKGLFQALDENLHQLHLTGYGISDTTLEEVFLM 4157
Query: 839 VGKLVDSSMDIQAIQLPALQYQHERRASDWAVDSNLCGAMDPSDGIGALIEEERTAVKLN 898
+ L DS+ + Q+ R S CG++ +
Sbjct: 4158 L--LQDSNKKSHIALGTESELQNHRPTGHL---SGYCGSLARPATV-------------- 4198
Query: 899 TGLALHCQQFWAMFLKKAAYSWREWKMVAAQVLVPLTCVTLALLAINYSSELFDDPMLRL 958
G+ L Q A+ ++ + R K A +L+P+ V LA+ + P LRL
Sbjct: 4199 QGVQLLRAQVAAILARRLRRTLRAGKSTLADLLLPVLFVALAMGLFMVRPLATEYPPLRL 4258
Query: 959 TLGEYGRTVVPFSVPGTSQL 978
T G Y R F G L
Sbjct: 4259 TPGHYQRAETYFFSSGGDNL 4278
Score = 392 bits (1007), Expect = e-108
Identities = 243/679 (35%), Positives = 359/679 (52%), Gaps = 41/679 (6%)
Query: 1036 TVVNALFNNQAYHSPATALAVVDNLLFKLLCGPHAS---IVVSNFPQPRSALQAAKDQFN 1092
T+ +N + +HS + L ++NL+ P ++ + P KD+
Sbjct: 4391 TLAKVWYNQKGFHSLPSYLNHLNNLILWQHLPPTVDWRQYGITLYSHPYGGALLNKDKIL 4450
Query: 1093 EGRKGFDIALNLLFAMAFLASTFSILAVSERAVQAKHVQFVSGVHVASFWLSALLWDLIS 1152
E + +AL ++ + L+++ V +R + AK +Q +SG+ +W + L+D++
Sbjct: 4451 ESIRQCGVALCIVLGFSILSASIGSSVVRDRVIGAKRLQHISGLGYRMYWFTNFLYDMLF 4510
Query: 1153 FLIPSLLLLVVFKAFDVRAFTRDGHMADTLLLLLLYGWAIIPLMYLMNFFFLGAATAYTR 1212
+L+ L + V AF + AFT ++A T LLL L+G+A +P MYLM+ F + A+
Sbjct: 4511 YLVSVCLCVAVIVAFQLTAFTFRKNLAATALLLSLFGYATLPWMYLMSRIFSSSDVAFIS 4570
Query: 1213 LTIFNILSGIATFLMVTIMRIPAV-----KLEELSKTLDHVFLVLPNHCLGMAVSSFYEN 1267
N + G+ T L+ + R+ A+ L+ + L VF + P CLG +
Sbjct: 4571 YVSLNFIFGLCTMLITIMPRLLAIISKAKNLQNIYDVLKWVFTIFPQFCLGQGLVELC-- 4628
Query: 1268 YETRRYCTSSEVAAHYCKKYNIQYQENFYAWSAPGVGRFVASMAASGCAYLILLFLIETN 1327
Y +Y + Y ++ NF W +A+ G L+L L+ +
Sbjct: 4629 YNQIKYDLTHNFGID---SYVSPFEMNFLGW-------IFVQLASQGTVLLLLRVLLHWD 4678
Query: 1328 LLQRLRGILCALRRRRTLTELYTRMPVLPEDQDVADERTRILAPSPDSLLHTPLIIKELS 1387
LL+ RG TL +D DV E R+ + + L++ LS
Sbjct: 4679 LLRWPRG-------HSTLQGTVKSS----KDTDVEKEEKRVFEGRTNGDI---LVLYNLS 4724
Query: 1388 KVYEQRVP-LLAVDRLSLAVQKGECFGLLGFNGAGKTTTFKMLTGEESLTSGDAFV---- 1442
K Y + ++AV +SL + KGECFGLLG NGAGK+TTFKML GE SLTSG A +
Sbjct: 4725 KHYRRFFQNIIAVQDISLGIPKGECFGLLGVNGAGKSTTFKMLNGEVSLTSGHAIIRTPM 4784
Query: 1443 GGHRISSDVGKVRQRIGYCPQFDALLDHMTGREMLVMYARLRGIPERHIGACVENTLRGL 1502
G S G IGYCPQ DAL + +TG E L Y LRGIP + I + +R L
Sbjct: 4785 GDAVDLSSAGTAGVLIGYCPQQDALDELLTGWEHLYYYCSLRGIPRQCIPEVAGDLIRRL 4844
Query: 1503 LLEPHANKLVRTYSGGNKRKLSTGIALIGEPAVIFLDEPSTGMDPVARRLLWDTVARARE 1562
LE HA+K V TYSGG KRKLST +AL+G+P ++ LDEPS+GMDP ++R LW T+ +
Sbjct: 4845 HLEAHADKPVATYSGGTKRKLSTALALVGKPDILLLDEPSSGMDPCSKRYLWQTIMKEVR 4904
Query: 1563 SGKAIIITSHSMEECEALCTRLAIMVQGQFKCLGSPQHLKSKFGSGYSLRAKVQSEGQQE 1622
G A ++TSHSMEECEALCTRLAIMV G FKCLGSPQH+K++FG GY+++ + E Q
Sbjct: 4905 EGCAAVLTSHSMEECEALCTRLAIMVNGSFKCLGSPQHIKNRFGDGYTVKVWLCKEANQH 4964
Query: 1623 ALEEFKAFVDLTFPGSVLEDEHQGMVHYHLPGRDLSWAKVFGILEKAKEKYGVDDYSVSQ 1682
+ L FPG + +H ++ YH+P R A +F ++E K + YS++Q
Sbjct: 4965 C--TVSDHLKLYFPGIQFKGQHLNLLEYHVPKRWGCLADLFKVIENNKTFLNIKHYSINQ 5022
Query: 1683 ISLEQVFLSFAHLQPPTAE 1701
+LEQVF++FA Q T +
Sbjct: 5023 TTLEQVFINFASEQQQTLQ 5041
Score = 191 bits (484), Expect = 7e-48
Identities = 175/656 (26%), Positives = 293/656 (44%), Gaps = 69/656 (10%)
Query: 240 VTIKRFPYPPFIA--DPFLVAI-QYQLPLLLLLSFTYTALTIARAVVQEKERRLKEYMRM 296
+T+ PY + D L +I Q + L ++L F+ + +I +VV+++ K +
Sbjct: 4432 ITLYSHPYGGALLNKDKILESIRQCGVALCIVLGFSILSASIGSSVVRDRVIGAKRLQHI 4491
Query: 297 MGLSSWLHWSAWFLLFFLFLLIAASFMTLLFCVKVKPNVAVLSRSDPSLVLAFLLCFAIS 356
GL ++W FL LF L++ + + A R + + L F +
Sbjct: 4492 SGLGYRMYWFTNFLYDMLFYLVSVCLCVAV--IVAFQLTAFTFRKNLAATALLLSLFGYA 4549
Query: 357 TISFSFMVSTFFSKANMAAAFGGFLYFFTYIPYFFVAPRYNWMTLSQKLCSCLLSNVAMA 416
T+ + +++S FS +++A F +Y+ F+ + T+ + LL+ ++ A
Sbjct: 4550 TLPWMYLMSRIFSSSDVA--------FISYVSLNFI---FGLCTMLITIMPRLLAIISKA 4598
Query: 417 MGAQLIGKFEAKGMGIQWRDLLSPVNVDDDFCFGQVLGMLLLDSVLYGLVTWYMEAVFPG 476
Q I ++W + P FC GQ L L + + Y L + +
Sbjct: 4599 KNLQNIYDV------LKWVFTIFP-----QFCLGQGLVELCYNQIKYDLTHNFGIDSYVS 4647
Query: 477 QFGVP-QPWYFFIMPSY-----------------WCGKPRAVAG--KEEEDSDPEKALRN 516
F + W F + S W + G K +D+D EK +
Sbjct: 4648 PFEMNFLGWIFVQLASQGTVLLLLRVLLHWDLLRWPRGHSTLQGTVKSSKDTDVEKEEKR 4707
Query: 517 EYFEAEPEDLVAGIKIKHLSKVFRVGNKDRAAVRDLNLNLYEGQITVLLGHNGAGKTTTL 576
+ D++ + +LSK +R ++ AV+D++L + +G+ LLG NGAGK+TT
Sbjct: 4708 VFEGRTNGDILV---LYNLSKHYRRFFQNIIAVQDISLGIPKGECFGLLGVNGAGKSTTF 4764
Query: 577 SMLTGLFPPTSGRAYISGYEISQDMVQIRKS------LGLCPQHDILFDNLTVAEHLYFY 630
ML G TSG A I D V + + +G CPQ D L + LT EHLY+Y
Sbjct: 4765 KMLNGEVSLTSGHAIIR--TPMGDAVDLSSAGTAGVLIGYCPQQDALDELLTGWEHLYYY 4822
Query: 631 AQLKGLSRQKCPEEVKQMLHIIGLEDKWNSRSRFLSGGMRRKLSIGIALIAGSKVLILDE 690
L+G+ RQ PE ++ + LE + SGG +RKLS +AL+ +L+LDE
Sbjct: 4823 CSLRGIPRQCIPEVAGDLIRRLHLEAHADKPVATYSGGTKRKLSTALALVGKPDILLLDE 4882
Query: 691 PTSGMDAISRRAIWDLLQRQ-KSDRTIVLTTHFMDEADLLGDRIAIMAKGELQCCGSSLF 749
P+SGMD S+R +W + ++ + VLT+H M+E + L R+AIM G +C GS
Sbjct: 4883 PSSGMDPCSKRYLWQTIMKEVREGCAAVLTSHSMEECEALCTRLAIMVNGSFKCLGSPQH 4942
Query: 750 LKQKYGAGY--HMTLVKE--PHCNPEDISQLVHHHVPNATLESSAGAELSFILPRESTHR 805
+K ++G GY + L KE HC D +L + P + L + +P+
Sbjct: 4943 IKNRFGDGYTVKVWLCKEANQHCTVSDHLKL---YFPGIQFKGQHLNLLEYHVPKR-WGC 4998
Query: 806 FEGLFAKLEKKQKELGIASFGASITTMEEVFLRVGKLVDSSMDIQAIQLPALQYQH 861
LF +E + L I + + TT+E+VF+ + +Q+ P+ H
Sbjct: 4999 LADLFKVIENNKTFLNIKHYSINQTTLEQVFINFAS--EQQQTLQSTLDPSTDSHH 5052
Score = 179 bits (455), Expect = 2e-44
Identities = 107/301 (35%), Positives = 165/301 (54%), Gaps = 11/301 (3%)
Query: 1399 VDRLSLAVQKGECFGLLGFNGAGKTTTFKMLTGEESLTSGDAFVGGHRISSDVGKVRQRI 1458
V LSL + + LLG NGAGKTT MLTG TSG + G + +D+ +VR +
Sbjct: 3858 VQDLSLTFYRDQITALLGTNGAGKTTIISMLTGLHPPTSGTIIINGKNLQTDLSRVRMEL 3917
Query: 1459 GYCPQFDALLDHMTGREMLVMYARLRG--IPERHIGACVENTLRGLLLEPHANKLVRTYS 1516
G CPQ D LLD++T RE L+++A ++ ++ + V TL+ + L H +K R S
Sbjct: 3918 GVCPQQDILLDNLTVREHLLLFASIKAPQWTKKELHQQVNQTLQDVDLTQHQHKQTRALS 3977
Query: 1517 GGNKRKLSTGIALIGEPAVIFLDEPSTGMDPVARRLLWDTVARARESGKAIIITSHSMEE 1576
GG KRKLS GIA +G + LDEP++G+DP +R LWD + + RE G+ II T+H ++E
Sbjct: 3978 GGLKRKLSLGIAFMGMSRTVVLDEPTSGVDPCSRHSLWDILLKYRE-GRTIIFTTHHLDE 4036
Query: 1577 CEALCTRLAIMVQGQFKCLGSPQHLKSKFGSGYSL----RAKVQSEGQQEALEEFKAFVD 1632
EAL R+A++ G+ +C G P LK +G G L + V + + + +
Sbjct: 4037 AEALSDRVAVLQHGRLRCCGPPFCLKEAYGQGLRLTLTRQPSVLEAHDLKDMACVTSLIK 4096
Query: 1633 LTFPGSVLEDEHQGMVHYHLPGRDLSWAKVFGILEKAKE---KYGVDDYSVSQISLEQVF 1689
+ P + L+D + Y +P +D A + G+ + E + + Y +S +LE+VF
Sbjct: 4097 IYIPQAFLKDSSGSELTYTIP-KDTDKACLKGLFQALDENLHQLHLTGYGISDTTLEEVF 4155
Query: 1690 L 1690
L
Sbjct: 4156 L 4156
>gi|27477115 ATP-binding cassette, sub-family A, member 9 [Homo
sapiens]
Length = 1624
Score = 342 bits (878), Expect = 1e-93
Identities = 270/871 (30%), Positives = 438/871 (50%), Gaps = 96/871 (11%)
Query: 1 MAVLRQLALLLWKNYTLQKRKVLVTVLELFLPLLFSGILIWLRLKIQSENVPNATIYPGQ 60
M+V +Q LL KN + R T+LE LFS +L+ L L + N+ P
Sbjct: 6 MSVGQQTWALLCKNCLKKWRMKRQTLLEW----LFSFLLV-LFLYLFFSNLHQVHDTPQM 60
Query: 61 SIQELPLFFTFPPPGDT-WELAYIPSHSDAAKTVTETVRRALVINMRVRGFPSEKDFEDY 119
S +L +F DT + +A+ P + + + + + G+P EK ++
Sbjct: 61 SSMDLGRVDSF---NDTNYVIAFAPESKTTQEIMNKVASAPFLKGRTIMGWPDEKSMDEL 117
Query: 120 IRYDNCSSSVLAAVVFEHPFNHSKEPLPLAVKYHLRFSYTRRNYMWTQTGSFFLKETEGW 179
D S V+F F+ YHL+FS+ R M +
Sbjct: 118 ---DLNYSIDAVRVIFTDTFS-----------YHLKFSWGHRIPMMKE------HRDHSA 157
Query: 180 HTTSLFPLFPNPGPREPTSPDGGEPGYIREGFLAVQHAVDRAIMEYHADAATRQLFQRLT 239
H ++ E +G E + +GF+A Q A++ AI+E + + + Q ++
Sbjct: 158 HCQAV---------NEKMKCEGSE--FWEKGFVAFQAAINAAIIEIATNHSVME--QLMS 204
Query: 240 VTIKRFPYPPFIADPFLVAIQYQLPLLLLLSFTYTALTIARAVVQEKERRLKEYMRMMGL 299
VT PF+A VA + + ++SF+ ++ V QE++ + M MMGL
Sbjct: 205 VTGVHMKILPFVAQGG-VATDFFI-FFCIISFSTFIYYVSVNVTQERQY-ITSLMTMMGL 261
Query: 300 SSWLHWSAWFLLFFLFLLIAASFMTLLFCVKVKPNVAVLSRSDPSLVLAFLLCFAISTIS 359
W +W L++ F+LI A+ M L+ + ++ + +V L + +S I+
Sbjct: 262 RESAFWLSWGLMYAGFILIMATLMALIV-----KSAQIVVLTGFVMVFTLFLLYGLSLIT 316
Query: 360 FSFMVSTFFSKANMAA-------AFGGFLYF---FTYIPYFFVAPRYNWMTLSQKLCSCL 409
+F++S K + F G L F +T +P F W CL
Sbjct: 317 LAFLMSVLIKKPFLTGLVVFLLIVFWGILGFPALYTRLPAFL-----EWTL-------CL 364
Query: 410 LSNVAMAMG-AQLIGKFEAKGMGIQWRDLLSPVNVDDD---FCFGQVLGMLLLDSVLYGL 465
LS A +G AQLI D+ S ++D + L ML+ D++LY +
Sbjct: 365 LSPFAFTVGMAQLIHLDY---------DVNSNAHLDSSQNPYLIIATLFMLVFDTLLYLV 415
Query: 466 VTWYMEAVFPGQFGVPQPWYFFIMPSYWC--GKPRAVAGKEEEDSDPEKALRNEYFEAEP 523
+T Y + + P ++G FF+ +W G+ V + E DSDP N+ FE
Sbjct: 416 LTLYFDKILPAEYGHRCSPLFFLKSCFWFQHGRANHVVLENETDSDPTP---NDCFEPVS 472
Query: 524 EDLVA--GIKIKHLSKVFRVGNKDRAAVRDLNLNLYEGQITVLLGHNGAGKTTTLSMLTG 581
+ I+IK+L K + + A++ + ++YEGQIT LLGH+GAGKTT L++L+G
Sbjct: 473 PEFCGKEAIRIKNLKKEYAGKCERVEALKGVVFDIYEGQITALLGHSGAGKTTLLNILSG 532
Query: 582 LFPPTSGRAYISGYEISQ--DMVQIRKSLGLCPQHDILFDNLTVAEHLYFYAQLKGLSRQ 639
L PTSG + + +S+ D+ I K G CPQ ++ F LTV E+L +A++KG+
Sbjct: 533 LSVPTSGSVTVYNHTLSRMADIENISKFTGFCPQSNVQFGFLTVKENLRLFAKIKGILPH 592
Query: 640 KCPEEVKQMLHIIGLEDKWNSRSRFLSGGMRRKLSIGIALIAGSKVLILDEPTSGMDAIS 699
+ +EV++++ + +E+ + ++ LSGG RKL+ GIA++ +VL+LDEPT+G+D +S
Sbjct: 593 EVEKEVQRVVQELEMENIQDILAQNLSGGQNRKLTFGIAILGDPQVLLLDEPTAGLDPLS 652
Query: 700 RRAIWDLLQRQKSDRTIVLTTHFMDEADLLGDRIAIMAKGELQCCGSSLFLKQKYGAGYH 759
R IW+LL+ KSDR I+ +T F+DEAD+L DR ++ G+L+C GSSLFLK+K+G GYH
Sbjct: 653 RHRIWNLLKEGKSDRVILFSTQFIDEADILADRKVFISNGKLKCAGSSLFLKKKWGIGYH 712
Query: 760 MTLVKEPHCNPEDISQLVHHHVPNATLESSAGAELSFILPRESTHRFEGLFAKLEKKQKE 819
++L C+PE I+ LV H+ +A L + + +L +ILP E T++F L+ L++ +
Sbjct: 713 LSLHLNERCDPESITSLVKQHISDAKLTAQSEEKLVYILPLERTNKFPELYRDLDRCSNQ 772
Query: 820 LGIASFGASITTMEEVFLRV-GKLVDSSMDI 849
GI +G SITT+ EVFL++ GK DI
Sbjct: 773 -GIEDYGVSITTLNEVFLKLEGKSTIDESDI 802
Score = 214 bits (545), Expect = 6e-55
Identities = 193/666 (28%), Positives = 313/666 (46%), Gaps = 75/666 (11%)
Query: 1063 KLLCGPHASIVVSN----FPQPRSALQAAKDQFNEGRKGFDIAL--NLLFAMAFLASTFS 1116
+L C P V+SN +Q + F E ++ N F + AS
Sbjct: 979 RLNCFPVLLDVISNGLLGIFNSSEHIQTDRSTFFEEHMDYEYGYRSNTFFWIPMAASFTP 1038
Query: 1117 ILAVSERAVQAK--HVQF-VSGVHVASFWLSALLWDLISFLIPSLLLLVVFKAFDVRAFT 1173
+A+S K H Q +SG++ +++W L D+ + + LL+ ++ F
Sbjct: 1039 YIAMSSIGDYKKKAHSQLRISGLYPSAYWFGQALVDVSLYFLILLLMQIMDYIFSPEEII 1098
Query: 1174 RDGHMADTLLLLLL----YGWAIIPLMYLMNFFFLGAATAYTRLTIFNILSGIATFLMVT 1229
+ LL+ +L Y +++ L Y+++F F + F FL+V
Sbjct: 1099 ---FIIQNLLIQILCSIGYVSSLVFLTYVISFIFRNGRKNSGIWSFF--------FLIVV 1147
Query: 1230 IMRIPAVKLEELSKT-LDHVFLVLPNHCLGMAVSSFYE-NYETRRYCTSSEVAAHYCKKY 1287
I I A L E L +++P L ++ F E + ++ Y +SE Y
Sbjct: 1148 IFSIVATDLNEYGFLGLFFGTMLIPPFTLIGSLFIFSEISPDSMDYLGASESEIVYL--- 1204
Query: 1288 NIQYQENFYAWSAPGVGRFVASMAASGCAYLILLFLI---ETNLLQRLRGILCALRRRRT 1344
++ +LI LF++ E N ++L R
Sbjct: 1205 ---------------------ALLIPYLHFLIFLFILRCLEMNCRKKLMRKDPVFRISPR 1243
Query: 1345 LTELYTRMPVLPE--DQDVADERTRIL-APSPDSLLHTPLIIKE-LSKVY--------EQ 1392
++ P PE ++D+ ER R + A + TP+II L K Y +
Sbjct: 1244 SNAIFPN-PEEPEGEEEDIQMERMRTVNAMAVRDFDETPVIIASCLRKEYAGKKKNCFSK 1302
Query: 1393 RVPLLAVDRLSLAVQKGECFGLLGFNGAGKTTTFKMLTGEESLTSGDAFVGGHRISSDVG 1452
R +A +S V+KGE GLLG NGAGK+TT KM+TG+ T+G + G S G
Sbjct: 1303 RKKKIATRNVSFCVKKGEVIGLLGHNGAGKSTTIKMITGDTKPTAGQVILKG----SGGG 1358
Query: 1453 KVRQRIGYCPQFDALLDHMTGREMLVMYARLRGIPERHIGACVENTLRGLLLEPHANKLV 1512
+ +GYCPQ +AL ++T R+ L +YA ++G+ + + + L L+ V
Sbjct: 1359 EPLGFLGYCPQENALWPNLTVRQHLEVYAAVKGLRKGDAMIAITRLVDALKLQDQLKAPV 1418
Query: 1513 RTYSGGNKRKLSTGIALIGEPAVIFLDEPSTGMDPVARRLLWDTV-ARARESGKAIIITS 1571
+T S G KRKL ++++G P+V+ LDEPSTGMDP ++ +W + A R + + ++T+
Sbjct: 1419 KTLSEGIKRKLCFVLSILGNPSVVLLDEPSTGMDPEGQQQMWQVIRATFRNTERGALLTT 1478
Query: 1572 HSMEECEALCTRLAIMVQGQFKCLGSPQHLKSKFGSGYSLRAKVQSEGQQEALEEFKAFV 1631
H M E EA+C R+AIMV G+ +C+GS QHLKSKFG Y L K+++ Q E L A +
Sbjct: 1479 HYMAEAEAVCDRVAIMVSGRLRCIGSIQHLKSKFGKDYLLEMKLKNLAQMEPLH---AEI 1535
Query: 1632 DLTFPGSVLEDEHQGMVHYHLPGRDL-SWAKVFGILEKAKEKYGVDDYSVSQISLEQVFL 1690
FP + ++ ++ Y LP D+ ++ F LE K+ + +++YS+SQ +LEQVFL
Sbjct: 1536 LRLFPQAAQQERFSSLMVYKLPVEDVRPLSQAFFKLEIVKQSFDLEEYSLSQSTLEQVFL 1595
Query: 1691 SFAHLQ 1696
+ Q
Sbjct: 1596 ELSKEQ 1601
Score = 176 bits (446), Expect = 2e-43
Identities = 105/347 (30%), Positives = 188/347 (54%), Gaps = 13/347 (3%)
Query: 504 EEEDSDPEK-----ALRNEYFEAEPEDLVAGIKIKHLSKVFRVGNK--DRAAVRDLNLNL 556
EEED E+ A+ F+ P + + ++ ++ K +K + A R+++ +
Sbjct: 1257 EEEDIQMERMRTVNAMAVRDFDETPVIIASCLRKEYAGKKKNCFSKRKKKIATRNVSFCV 1316
Query: 557 YEGQITVLLGHNGAGKTTTLSMLTGLFPPTSGRAYISGYEISQDMVQIRKSLGLCPQHDI 616
+G++ LLGHNGAGK+TT+ M+TG PT+G+ + G + + LG CPQ +
Sbjct: 1317 KKGEVIGLLGHNGAGKSTTIKMITGDTKPTAGQVILKGSGGGEPL----GFLGYCPQENA 1372
Query: 617 LFDNLTVAEHLYFYAQLKGLSRQKCPEEVKQMLHIIGLEDKWNSRSRFLSGGMRRKLSIG 676
L+ NLTV +HL YA +KGL + + +++ + L+D+ + + LS G++RKL
Sbjct: 1373 LWPNLTVRQHLEVYAAVKGLRKGDAMIAITRLVDALKLQDQLKAPVKTLSEGIKRKLCFV 1432
Query: 677 IALIAGSKVLILDEPTSGMDAISRRAIWDLLQR--QKSDRTIVLTTHFMDEADLLGDRIA 734
++++ V++LDEP++GMD ++ +W +++ + ++R +LTTH+M EA+ + DR+A
Sbjct: 1433 LSILGNPSVVLLDEPSTGMDPEGQQQMWQVIRATFRNTERGALLTTHYMAEAEAVCDRVA 1492
Query: 735 IMAKGELQCCGSSLFLKQKYGAGYHMTLVKEPHCNPEDISQLVHHHVPNATLESSAGAEL 794
IM G L+C GS LK K+G Y + + + E + + P A + + +
Sbjct: 1493 IMVSGRLRCIGSIQHLKSKFGKDYLLEMKLKNLAQMEPLHAEILRLFPQAAQQERFSSLM 1552
Query: 795 SFILPRESTHRFEGLFAKLEKKQKELGIASFGASITTMEEVFLRVGK 841
+ LP E F KLE ++ + + S +T+E+VFL + K
Sbjct: 1553 VYKLPVEDVRPLSQAFFKLEIVKQSFDLEEYSLSQSTLEQVFLELSK 1599
Score = 152 bits (383), Expect = 3e-36
Identities = 96/323 (29%), Positives = 171/323 (52%), Gaps = 9/323 (2%)
Query: 1372 SPDSLLHTPLIIKELSKVYEQRVPLL-AVDRLSLAVQKGECFGLLGFNGAGKTTTFKMLT 1430
SP+ + IK L K Y + + A+ + + +G+ LLG +GAGKTT +L+
Sbjct: 472 SPEFCGKEAIRIKNLKKEYAGKCERVEALKGVVFDIYEGQITALLGHSGAGKTTLLNILS 531
Query: 1431 GEESLTSGDAFVGGHRIS--SDVGKVRQRIGYCPQFDALLDHMTGREMLVMYARLRGIPE 1488
G TSG V H +S +D+ + + G+CPQ + +T +E L ++A+++GI
Sbjct: 532 GLSVPTSGSVTVYNHTLSRMADIENISKFTGFCPQSNVQFGFLTVKENLRLFAKIKGILP 591
Query: 1489 RHIGACVENTLRGLLLEPHANKLVRTYSGGNKRKLSTGIALIGEPAVIFLDEPSTGMDPV 1548
+ V+ ++ L +E + L + SGG RKL+ GIA++G+P V+ LDEP+ G+DP+
Sbjct: 592 HEVEKEVQRVVQELEMENIQDILAQNLSGGQNRKLTFGIAILGDPQVLLLDEPTAGLDPL 651
Query: 1549 ARRLLWDTVARARESGKAIIITSHSMEECEALCTRLAIMVQGQFKCLGSPQHLKSKFGSG 1608
+R +W+ + + S + I+ ++ ++E + L R + G+ KC GS LK K+G G
Sbjct: 652 SRHRIWNLLKEGK-SDRVILFSTQFIDEADILADRKVFISNGKLKCAGSSLFLKKKWGIG 710
Query: 1609 YSLRAKVQSEGQQEALEEFKAFVDLTFPGSVLEDEHQGMVHYHLP-GRDLSWAKVFGILE 1667
Y L + E++ + V + L + + + Y LP R + +++ L+
Sbjct: 711 YHLSLHLNERCDPESI---TSLVKQHISDAKLTAQSEEKLVYILPLERTNKFPELYRDLD 767
Query: 1668 KAKEKYGVDDYSVSQISLEQVFL 1690
+ + G++DY VS +L +VFL
Sbjct: 768 RCSNQ-GIEDYGVSITTLNEVFL 789
Score = 31.2 bits (69), Expect = 9.0
Identities = 28/105 (26%), Positives = 46/105 (43%), Gaps = 12/105 (11%)
Query: 1135 GVHVASFWLSALLWDLISFLIPSLLLLVVFKAFDVRAFTRDGHMADTLLLLLLYGWAIIP 1194
G+ ++FWLS L LI + L+ ++ K+ + T L LLYG ++I
Sbjct: 260 GLRESAFWLSWGLMYAGFILIMATLMALIVKSAQIVVLTG---FVMVFTLFLLYGLSLIT 316
Query: 1195 LMYLMNFF----FLGAATAYTRLTIFNILSGIATFLMVTIMRIPA 1235
L +LM+ FL + + + IL A + R+PA
Sbjct: 317 LAFLMSVLIKKPFLTGLVVFLLIVFWGILGFPALY-----TRLPA 356
>gi|153792144 ATP-binding cassette, sub-family A, member 10 [Homo
sapiens]
Length = 1543
Score = 325 bits (834), Expect = 2e-88
Identities = 207/640 (32%), Positives = 344/640 (53%), Gaps = 27/640 (4%)
Query: 206 YIREGFLAVQHAVDRAIMEYHADAATRQLFQRLTVTIK-RFPYPPFIADPFLVAIQYQLP 264
Y +GF+A Q A++ AI+E + + LT I PPFI+ ++ +
Sbjct: 83 YWLKGFVAFQAAINAAIIEV---TTNHSVMEELTSVIGINMKIPPFISKGEIMNEWFHFT 139
Query: 265 LLLLLS-FTYTA-LTIARAVVQEKERRLKEYMRMMGLSSWLHWSAWFLLFFLFLLIAASF 322
L+ S F Y A L +AR + + K+ M +MGL W +W L + F+ I + F
Sbjct: 140 CLVSFSSFIYFASLNVAR-----ERGKFKKLMTVMGLRESAFWLSWGLTYICFIFIMSIF 194
Query: 323 MTLLFCVKVKPNVAVLSRSDPSLVLAFLLCFAISTISFSFMVSTFFSKANMAAAFGGFLY 382
M L+ ++ ++ + ++ + +S I+ +F++S K M A GFL+
Sbjct: 195 MALVIT-----SIPIVFHTGFMVIFTLYSLYGLSLIALAFLMSVLIRKP-MLAGLAGFLF 248
Query: 383 FFTYIPYFFVAPRYNWMTLSQKLCSCLLSNVAMAMGAQLIGKFEAKGMGIQWRDLLSPVN 442
+ F Y + LS LLS A G I + G+ + P
Sbjct: 249 TVFWGCLGFTV-LYRQLPLSLGWVLSLLSPFAFTAGMAQITHLDNYLSGV-----IFPDP 302
Query: 443 VDDDFCFGQVLGMLLLDSVLYGLVTWYMEAVFPGQFGVPQPWYFFIMPSYWCGKPRAVAG 502
D + +L D++ Y + T Y E V P + G FF+ S+W
Sbjct: 303 SGDSYKMIATFFILAFDTLFYLIFTLYFERVLPDKDGHGDSPLFFLKSSFWSKHQNTHHE 362
Query: 503 KEEEDSDPEKALRNEYFEAEPE-DLVAGIKIKHLSKVFRVGNKDRAAVRDLNLNLYEGQI 561
E + +PE + + + PE I+I+++ K + A++ + ++YEGQI
Sbjct: 363 IFENEINPEHSSDDSFEPVSPEFHGKEAIRIRNVIKEYNGKTGKVEALQGIFFDIYEGQI 422
Query: 562 TVLLGHNGAGKTTTLSMLTGLFPPTSGRAYISGYEISQ--DMVQIRKSLGLCPQHDILFD 619
T +LGHNGAGK+T L++L+GL T G A I ++S+ DM +IRK++G CPQ + FD
Sbjct: 423 TAILGHNGAGKSTLLNILSGLSVSTEGSATIYNTQLSEITDMEEIRKNIGFCPQFNFQFD 482
Query: 620 NLTVAEHLYFYAQLKGLSRQKCPEEVKQMLHIIGLEDKWNSRSRFLSGGMRRKLSIGIAL 679
LTV E+L +A++KG+ ++ +EVK+++ + ++ + ++ LSGG +RKL++GIA+
Sbjct: 483 FLTVRENLRVFAKIKGIQPKEVEQEVKRIIMELDMQSIQDIIAKKLSGGQKRKLTLGIAI 542
Query: 680 IAGSKVLILDEPTSGMDAISRRAIWDLLQRQKSDRTIVLTTHFMDEADLLGDRIAIMAKG 739
+ +VL+LDEPT+G+D SR +W LL+ K DR I+ +T FMDEAD+L DR ++ G
Sbjct: 543 LGDPQVLLLDEPTAGLDPFSRHRVWSLLKEHKVDRLILFSTQFMDEADILADRKVFLSNG 602
Query: 740 ELQCCGSSLFLKQKYGAGYHMTLVKEPHCNPEDISQLVHHHVPNATLESSAGAELSFILP 799
+L+C GSSLFLK+K+G GYH++L + C+ E I+ L+ H+P+A L + + +L + LP
Sbjct: 603 KLKCAGSSLFLKRKWGIGYHLSLHRNEMCDTEKITSLIKQHIPDAKLTTESEEKLVYSLP 662
Query: 800 RESTHRFEGLFAKLEKKQKELGIASFGASITTMEEVFLRV 839
E T++F L++ L+K + GI ++ S+T++ EVFL +
Sbjct: 663 LEKTNKFPDLYSDLDKCSDQ-GIRNYAVSVTSLNEVFLNL 701
Score = 204 bits (520), Expect = 5e-52
Identities = 128/359 (35%), Positives = 198/359 (55%), Gaps = 27/359 (7%)
Query: 1357 EDQDVADERTRIL-APSPDSLLHTPLIIKE-LSKVYEQ--------RVPLLAVDRLSLAV 1406
ED+DV ER + A + +L P+I L K Y + R +A+ +S V
Sbjct: 1170 EDEDVQAERVQAANALTAPNLEEEPVITASCLHKEYYETKKSCFSTRKKKIAIRNVSFCV 1229
Query: 1407 QKGECFGLLGFNGAGKTTTFKMLTGEESLTSGDAFVGGHRISSDVGKVRQR-------IG 1459
+KGE GLLG NGAGK+T+ KM+TG T+G + G R S VRQ+ +G
Sbjct: 1230 KKGEVLGLLGHNGAGKSTSIKMITGCTKPTAGVVVLQGSRAS-----VRQQHDNSLKFLG 1284
Query: 1460 YCPQFDALLDHMTGREMLVMYARLRGIPERHIGACVENTLRGLLLEPHANKLVRTYSGGN 1519
YCPQ ++L +T +E L +YA ++G+ + + + L L+ V+T S G
Sbjct: 1285 YCPQENSLWPKLTMKEHLELYAAVKGLGKEDAALSISRLVEALKLQEQLKAPVKTLSEGI 1344
Query: 1520 KRKLSTGIALIGEPAVIFLDEPSTGMDPVARRLLWDTV-ARARESGKAIIITSHSMEECE 1578
KRKL ++++G P+V+ LDEP TGMDP ++ +W + A + + ++T+H M E E
Sbjct: 1345 KRKLCFVLSILGNPSVVLLDEPFTGMDPEGQQQMWQILQATVKNKERGTLLTTHYMSEAE 1404
Query: 1579 ALCTRLAIMVQGQFKCLGSPQHLKSKFGSGYSLRAKVQSEGQQEALEEFKAFVDLTFPGS 1638
A+C R+A+MV G +C+GS QHLK+KFG Y L K++ Q EAL + FP +
Sbjct: 1405 AVCDRMAMMVSGTLRCIGSIQHLKNKFGRDYLLEIKMKEPTQVEALH---TEILKLFPQA 1461
Query: 1639 VLEDEHQGMVHYHLPGRDL-SWAKVFGILEKAKEKYGVDDYSVSQISLEQVFLSFAHLQ 1696
++ + ++ Y LP D+ ++ F LE K+ + +++YS+SQ +LEQVFL Q
Sbjct: 1462 AWQERYSSLMAYKLPVEDVHPLSRAFFKLEAMKQTFNLEEYSLSQATLEQVFLELCKEQ 1520
Score = 186 bits (471), Expect = 2e-46
Identities = 153/595 (25%), Positives = 278/595 (46%), Gaps = 31/595 (5%)
Query: 265 LLLLLSFTYTALTIARAVVQEKERRLKEYMRMMGLSSWLHWSAWFLLFF-LFLLIAASFM 323
+ LLL + I + + + ++ ++ + + GL +W L+ L+ LI S
Sbjct: 937 IFLLLITNCVSPFIGMSSISDYKKNVQSQLWISGLWPSAYWCGQALVDIPLYFLILFSIH 996
Query: 324 TLLFCVKVKPNVAVLSRSDPSLVLAFLLCF---AISTISFSFMVSTFFSKANMAAAFGGF 380
+ + + + ++ L+ ++C A+S I ++++S F K F F
Sbjct: 997 LIYYFIFLGFQLSW------ELMFVLVVCIIGCAVSLIFLTYVLSFIFRKWRKNNGFWSF 1050
Query: 381 LYFFTYIPYFFVAPRYNWMTLSQKLCSCLLSNVAMAMGAQLIGKFEAKGMGIQWRDLLSP 440
+F I + + L+ LC + + + L+ + + R+L S
Sbjct: 1051 GFFIILICVSTIMVSTQYEKLNLILCMIFIPSFTLLGYVMLLIQLDFM------RNLDSL 1104
Query: 441 VNVDDDFCFGQVLGMLL--LDSVLYGLVTWYMEAVFPGQFGVPQPWYFFIMPSYWCGKPR 498
N ++ +L L+ L SV++ V +E + + P F I P P
Sbjct: 1105 DNRINEVNKTILLTTLIPYLQSVIFLFVIRCLEMKYGNEIMNKDP-VFRISPRSRETHPN 1163
Query: 499 AVAGKEE-EDSDPEK-----ALRNEYFEAEPEDLVAGIKIKHLS--KVFRVGNKDRAAVR 550
+EE ED E+ AL E EP + + ++ K K + A+R
Sbjct: 1164 PEEPEEEDEDVQAERVQAANALTAPNLEEEPVITASCLHKEYYETKKSCFSTRKKKIAIR 1223
Query: 551 DLNLNLYEGQITVLLGHNGAGKTTTLSMLTGLFPPTSGRAYISGYEIS--QDMVQIRKSL 608
+++ + +G++ LLGHNGAGK+T++ M+TG PT+G + G S Q K L
Sbjct: 1224 NVSFCVKKGEVLGLLGHNGAGKSTSIKMITGCTKPTAGVVVLQGSRASVRQQHDNSLKFL 1283
Query: 609 GLCPQHDILFDNLTVAEHLYFYAQLKGLSRQKCPEEVKQMLHIIGLEDKWNSRSRFLSGG 668
G CPQ + L+ LT+ EHL YA +KGL ++ + +++ + L+++ + + LS G
Sbjct: 1284 GYCPQENSLWPKLTMKEHLELYAAVKGLGKEDAALSISRLVEALKLQEQLKAPVKTLSEG 1343
Query: 669 MRRKLSIGIALIAGSKVLILDEPTSGMDAISRRAIWDLLQR--QKSDRTIVLTTHFMDEA 726
++RKL ++++ V++LDEP +GMD ++ +W +LQ + +R +LTTH+M EA
Sbjct: 1344 IKRKLCFVLSILGNPSVVLLDEPFTGMDPEGQQQMWQILQATVKNKERGTLLTTHYMSEA 1403
Query: 727 DLLGDRIAIMAKGELQCCGSSLFLKQKYGAGYHMTLVKEPHCNPEDISQLVHHHVPNATL 786
+ + DR+A+M G L+C GS LK K+G Y + + + E + + P A
Sbjct: 1404 EAVCDRMAMMVSGTLRCIGSIQHLKNKFGRDYLLEIKMKEPTQVEALHTEILKLFPQAAW 1463
Query: 787 ESSAGAELSFILPRESTHRFEGLFAKLEKKQKELGIASFGASITTMEEVFLRVGK 841
+ + +++ LP E H F KLE ++ + + S T+E+VFL + K
Sbjct: 1464 QERYSSLMAYKLPVEDVHPLSRAFFKLEAMKQTFNLEEYSLSQATLEQVFLELCK 1518
Score = 162 bits (410), Expect = 3e-39
Identities = 146/585 (24%), Positives = 267/585 (45%), Gaps = 42/585 (7%)
Query: 1115 FSILAVSERAVQAKHVQFVSGVHVASFWLSALLWDLISFLIPSLLLLVVFKAFDVRAFTR 1174
F+ L V+ + K + V G+ ++FWLS L + I S+ + +V + + T
Sbjct: 150 FASLNVARERGKFKKLMTVMGLRESAFWLSWGLTYICFIFIMSIFMALVITSIPIVFHT- 208
Query: 1175 DGHMADTLLLLLLYGWAIIPLMYLMNFFFLGAATAYTRLTIFNILSGIATFLMVTIMRIP 1234
G M L LYG ++I L +LM+ A +F + G F
Sbjct: 209 -GFMV-IFTLYSLYGLSLIALAFLMSVLIRKPMLAGLAGFLFTVFWGCLGF--------- 257
Query: 1235 AVKLEELSKTLDHVFLVLPNHCL--GMAVSSFYENYETRRYCT--SSEVAAHYCKKYNIQ 1290
V +L +L V +L GMA + +NY + S + + +
Sbjct: 258 TVLYRQLPLSLGWVLSLLSPFAFTAGMAQITHLDNYLSGVIFPDPSGDSYKMIATFFILA 317
Query: 1291 YQENFYAWSAPGVGRFVASMAASGCAYLILLFLIETNLLQRLRGILCALRRRRTLTELYT 1350
+ FY R + G + L F ++++ + + T E++
Sbjct: 318 FDTLFYLIFTLYFERVLPDKDGHGDSPL---FFLKSSFWSK---------HQNTHHEIFE 365
Query: 1351 RMPVLPEDQDVADERTRILAPSPDSLLHTPLIIKELSKVYEQRVPLL-AVDRLSLAVQKG 1409
D + E SP+ + I+ + K Y + + A+ + + +G
Sbjct: 366 NEINPEHSSDDSFEPV-----SPEFHGKEAIRIRNVIKEYNGKTGKVEALQGIFFDIYEG 420
Query: 1410 ECFGLLGFNGAGKTTTFKMLTGEESLTSGDAFVGGHRIS--SDVGKVRQRIGYCPQFDAL 1467
+ +LG NGAGK+T +L+G T G A + ++S +D+ ++R+ IG+CPQF+
Sbjct: 421 QITAILGHNGAGKSTLLNILSGLSVSTEGSATIYNTQLSEITDMEEIRKNIGFCPQFNFQ 480
Query: 1468 LDHMTGREMLVMYARLRGIPERHIGACVENTLRGLLLEPHANKLVRTYSGGNKRKLSTGI 1527
D +T RE L ++A+++GI + + V+ + L ++ + + + SGG KRKL+ GI
Sbjct: 481 FDFLTVRENLRVFAKIKGIQPKEVEQEVKRIIMELDMQSIQDIIAKKLSGGQKRKLTLGI 540
Query: 1528 ALIGEPAVIFLDEPSTGMDPVARRLLWDTVARARESGKAIIITSHSMEECEALCTRLAIM 1587
A++G+P V+ LDEP+ G+DP +R +W ++ + + + I+ ++ M+E + L R +
Sbjct: 541 AILGDPQVLLLDEPTAGLDPFSRHRVW-SLLKEHKVDRLILFSTQFMDEADILADRKVFL 599
Query: 1588 VQGQFKCLGSPQHLKSKFGSGYSLRAKVQSEGQQEALEEFKAFVDLTFPGSVLEDEHQGM 1647
G+ KC GS LK K+G GY L + E+ + + P + L E +
Sbjct: 600 SNGKLKCAGSSLFLKRKWGIGYHLSL---HRNEMCDTEKITSLIKQHIPDAKLTTESEEK 656
Query: 1648 VHYHLP-GRDLSWAKVFGILEKAKEKYGVDDYSVSQISLEQVFLS 1691
+ Y LP + + ++ L+K ++ G+ +Y+VS SL +VFL+
Sbjct: 657 LVYSLPLEKTNKFPDLYSDLDKCSDQ-GIRNYAVSVTSLNEVFLN 700
>gi|6005701 ATP-binding cassette, sub-family A member 8 [Homo sapiens]
Length = 1581
Score = 298 bits (762), Expect = 4e-80
Identities = 277/1036 (26%), Positives = 473/1036 (45%), Gaps = 162/1036 (15%)
Query: 208 REGFLAVQHAVDRAIMEYHADAATRQLFQRLTVTIKRFPYPPFIADPFLVAIQYQLPLLL 267
+EGF+A+Q A++ AI+E + + + + ++VT K FI ++ Y ++
Sbjct: 174 KEGFVALQAAINAAIIEITTNHSVME--ELMSVTGKNMKMHSFIGQSGVITDLYLFSCII 231
Query: 268 LLSFTYTALTIARAVVQEKERRLKEYMRMMGLSSWLHWSAWFLLFFLFLLIAASFMTLLF 327
S + + A V + +R+K M MMGL W +W LL+ F+ I A F+ L+
Sbjct: 232 SFS---SFIYYASVNVTRERKRMKALMTMMGLRDSAFWLSWGLLYAGFIFIMALFLALVI 288
Query: 328 CVKVKPNVAVLSRSDPSLVLAFLLCFAISTISFSFMVSTFFSKANMAAAFGGFLYFFTYI 387
+ + S +V + L + +S ++ +F++S K+ + L F
Sbjct: 289 -----RSTQFIILSGFMVVFSLFLLYGLSLVALAFLMSILVKKSFLTGLVVFLLTVFWGC 343
Query: 388 PYFFVAPRYNWMTLSQKLCSCLLSNVAMAMG-AQLIGKFEAKGMGIQWRDLLSPVNVDDD 446
F Y + S + LLS A +G AQL+ + P D
Sbjct: 344 LGF--TSLYRHLPASLEWILSLLSPFAFMLGMAQLLH------LDYDLNSNAFPHPSDGS 395
Query: 447 FCFGQVLGMLLLDSVLYGLVTWYMEAVFPGQFGVPQPWYFFIMPSYWCGKPRA--VAGKE 504
ML D+ LY + Y E + P ++G +P FF+ S+W + VA ++
Sbjct: 396 NLIVATNFMLAFDTCLYLALAIYFEKILPNEYGHRRPPLFFLKSSFWSQTQKTDHVALED 455
Query: 505 EEDSDPEKALRNEYFEAEPE-DLVAGIKIKHLSKVFRVGNKDRA-AVRDLNLNLYEGQIT 562
E D+DP + + + +A PE I+I++++K ++ G D+ A++DL ++YEGQIT
Sbjct: 456 EMDADP--SFHDSFEQAPPEFQGKEAIRIRNVTKEYK-GKPDKIEALKDLVFDIYEGQIT 512
Query: 563 VLLGHNGAGKTTTLSMLTGLFPPTSGRAYISGYEISQ--DMVQIRKSLGLCPQHDILFDN 620
+LGH+GAGK+T L++L+GL PT G I ++S+ D+ + K G+CPQ ++ FD
Sbjct: 513 AILGHSGAGKSTLLNILSGLSVPTKGSVTIYNNKLSEMADLENLSKLTGVCPQSNVQFDF 572
Query: 621 LTVAEHLYFYAQLKGLSRQKCPEEVKQMLHIIGLEDKWNSRSRFLSGGMRRKLSIGIALI 680
LTV E+L +A++KG+ P+EV +
Sbjct: 573 LTVRENLRLFAKIKGI----LPQEVDK--------------------------------- 595
Query: 681 AGSKVLILDEPTSGMDAISRRAIWDLLQRQKSDRTIVLTTHFMDEADLLGDRIAIMAKGE 740
++ +LDEPT+G+D SR +W+LL+ +K+DR I+ +T FMDEAD+L DR +++G+
Sbjct: 596 ---EIFLLDEPTAGLDPFSRHQVWNLLKERKTDRVILFSTQFMDEADILADRKVFLSQGK 652
Query: 741 LQCCGSSLFLKQKYGAGYHMTLVKEPHCNPEDISQLVHHHVPNATLESSAGAELSFILPR 800
L+C GSSLFLK+K+G GYH++L C E+I+ LV H+P+A L + + +L + LP
Sbjct: 653 LKCAGSSLFLKKKWGIGYHLSLQLNEICVEENITSLVKQHIPDAKLSAKSEGKLIYTLPL 712
Query: 801 ESTHRFEGLFAKLEKKQKELGIASFGASITTMEEVFLRV-GKLVDSSMDIQAIQLPALQY 859
E T++F L+ L+ +LGI ++G S+TT+ EVFL++ GK + DI + +
Sbjct: 713 ERTNKFPELYKDLD-SYPDLGIENYGVSMTTLNEVFLKLEGKSTINESDIAILG----EV 767
Query: 860 QHERRASDWAVDSNLCGAMDPSDGIGALIEEERTAVKLNT------GLALHCQQFWAMFL 913
Q E+ +D L+E E+ LN G+AL QQ A+
Sbjct: 768 QAEK-----------------ADDTERLVEMEQVLSSLNKMRKTIGGVALWRQQICAIAR 810
Query: 914 KKAAYSWREWKMVAAQVLVPLTCVTLALLAINYSSELFDDPMLRLTLGEYGRTVVPFSVP 973
+ E K + A +L+ L + L + M+++ Y
Sbjct: 811 VRLLKLKHERKALLALLLI---------LMAGFCPLLVEYTMVKIYQNSY---------- 851
Query: 974 GTSQLGQQLSEHLKDALQAEGQEPREVLGDLEEFLIFRASVEGGGF---NERCLVAASFR 1030
+LS HL A GQ+P + L L +I + F E +A
Sbjct: 852 -----TWELSPHL--YFLAPGQQPHDPLTQL--LIINKTGASIDDFIQSVEHQNIALEVD 902
Query: 1031 DVGERTVVNALFNNQAYHSPATALAVVDNLLFKLLCG-------PHASIVVSN----FPQ 1079
G R ++ +Y+ T N F L C P +VSN +
Sbjct: 903 AFGTRNGT----DDPSYNGAITVCCNEKNYSFSLACNAKRLNCFPVLMDIVSNGLLGMVK 958
Query: 1080 PRSALQAAKDQFNEGRKGFDIALNLLFAMAFLASTFS------ILAVSERAVQAKHVQFV 1133
P ++ + F E + I L + M +L T S + ++ + +A+ +
Sbjct: 959 PSVHIRTERSTFLENGQDNPIGF-LAYIMFWLVLTSSCPPYIAMSSIDDYKNRARSQLRI 1017
Query: 1134 SGVHVASFWLSALLWDLISFLIPSLLLLVVFKAFDVRAFTRDGHMADTLLLLLL------ 1187
SG+ +++W L D+ SL LV + + + M T++ ++
Sbjct: 1018 SGLSPSAYWFGQALVDV------SLYFLVFVFIYLMSYISNFEDMLLTIIHIIQIPCAVG 1071
Query: 1188 YGWAIIPLMYLMNFFF 1203
Y +++I + Y+++F F
Sbjct: 1072 YSFSLIFMTYVISFIF 1087
Score = 218 bits (555), Expect = 4e-56
Identities = 133/352 (37%), Positives = 202/352 (57%), Gaps = 19/352 (5%)
Query: 1357 EDQDVADERTRIL-APSPDSLLHTPLIIKE-LSKVY--------EQRVPLLAVDRLSLAV 1406
ED+DV ER R A + + P+II L K Y +R +A +S V
Sbjct: 1214 EDEDVQMERVRTANALNSTNFDEKPVIIASCLRKEYAGKRKGCFSKRKNKIATRNVSFCV 1273
Query: 1407 QKGECFGLLGFNGAGKTTTFKMLTGEESLTSGDAFVGGHRISSDVGKVRQRIGYCPQFDA 1466
+KGE GLLG NGAGK+T+ K++TG+ T+G + G S G + +GYCPQ +A
Sbjct: 1274 RKGEVLGLLGHNGAGKSTSIKVITGDTKPTAGQVLLKG----SGGGDALEFLGYCPQENA 1329
Query: 1467 LLDHMTGREMLVMYARLRGIPERHIGACVENTLRGLLLEPHANKLVRTYSGGNKRKLSTG 1526
L ++T R+ L +YA ++G+ + + + L L+ V+T S G KRKL
Sbjct: 1330 LWPNLTVRQHLEVYAAVKGLRKGDAEVAITRLVDALKLQDQLKSPVKTLSEGIKRKLCFV 1389
Query: 1527 IALIGEPAVIFLDEPSTGMDPVARRLLWDTV-ARARESGKAIIITSHSMEECEALCTRLA 1585
++++G P+V+ LDEPSTGMDP ++ +W + A R + + ++T+H M E EA+C R+A
Sbjct: 1390 LSILGNPSVVLLDEPSTGMDPEGQQQMWQAIRATFRNTERGALLTTHYMAEAEAVCDRVA 1449
Query: 1586 IMVQGQFKCLGSPQHLKSKFGSGYSLRAKVQSEGQQEALEEFKAFVDLTFPGSVLEDEHQ 1645
IMV G+ +C+GS QHLKSKFG Y L KV++ Q E L A + FP + ++ +
Sbjct: 1450 IMVSGRLRCIGSIQHLKSKFGKDYLLEMKVKNLAQVEPLH---AEILRLFPQAARQERYS 1506
Query: 1646 GMVHYHLPGRDLS-WAKVFGILEKAKEKYGVDDYSVSQISLEQVFLSFAHLQ 1696
++ Y LP D+ A+ F LEK K+ + +++YS+SQ +LEQVFL + Q
Sbjct: 1507 SLMVYKLPVEDVQPLAQAFFKLEKVKQSFDLEEYSLSQSTLEQVFLELSKEQ 1558
Score = 189 bits (481), Expect = 2e-47
Identities = 157/599 (26%), Positives = 286/599 (47%), Gaps = 76/599 (12%)
Query: 278 IARAVVQEKERRLKEYMRMMGLSSWLHW--------SAWFLLF-FLFLLIAAS-----FM 323
IA + + + + R + +R+ GLS +W S +FL+F F++L+ S +
Sbjct: 999 IAMSSIDDYKNRARSQLRISGLSPSAYWFGQALVDVSLYFLVFVFIYLMSYISNFEDMLL 1058
Query: 324 TLLFCVKVKPNVAVLSRSDPSLVLAFLLCFAI-------STISFSFMVSTFFSKANMAAA 376
T++ +++ + S + + +++ F SF F V T FS A A
Sbjct: 1059 TIIHIIQIP---CAVGYSFSLIFMTYVISFIFRKGRKNSGIWSFCFYVVTVFSVAGFA-- 1113
Query: 377 FGGFLYFFTYIPYFFVAPRYNWMTLSQKLCSCLLSNVAMAMGAQLIGKFEAKGMGIQ-WR 435
F F + IP+ F ++ + CL + + + F + M +Q +
Sbjct: 1114 ---FSIFESDIPFIFT-----FLIPPATMIGCLFLSSHLLFSSL----FSEERMDVQPFL 1161
Query: 436 DLLSPVNVDDDFCFGQVLGMLLLDSVLYGLVTWYMEAVFPGQFGVPQPWYFFIMP--SYW 493
L P L +++ +E F G+ + + +F I P S
Sbjct: 1162 VFLIP----------------FLHFIIFLFTLRCLEWKF-GKKSMRKDPFFRISPRSSDV 1204
Query: 494 CGKPRAVAGKEEEDSDPEK-----ALRNEYFEAEPEDLVAGIKIKHLSKVFRVG----NK 544
C P G E+ED E+ AL + F+ +P + + ++ ++ K R G K
Sbjct: 1205 CQNPEEPEG-EDEDVQMERVRTANALNSTNFDEKPVIIASCLRKEYAGK--RKGCFSKRK 1261
Query: 545 DRAAVRDLNLNLYEGQITVLLGHNGAGKTTTLSMLTGLFPPTSGRAYISGYEISQDMVQI 604
++ A R+++ + +G++ LLGHNGAGK+T++ ++TG PT+G+ + G +
Sbjct: 1262 NKIATRNVSFCVRKGEVLGLLGHNGAGKSTSIKVITGDTKPTAGQVLLKGSGGGDAL--- 1318
Query: 605 RKSLGLCPQHDILFDNLTVAEHLYFYAQLKGLSRQKCPEEVKQMLHIIGLEDKWNSRSRF 664
+ LG CPQ + L+ NLTV +HL YA +KGL + + +++ + L+D+ S +
Sbjct: 1319 -EFLGYCPQENALWPNLTVRQHLEVYAAVKGLRKGDAEVAITRLVDALKLQDQLKSPVKT 1377
Query: 665 LSGGMRRKLSIGIALIAGSKVLILDEPTSGMDAISRRAIWDLLQR--QKSDRTIVLTTHF 722
LS G++RKL ++++ V++LDEP++GMD ++ +W ++ + ++R +LTTH+
Sbjct: 1378 LSEGIKRKLCFVLSILGNPSVVLLDEPSTGMDPEGQQQMWQAIRATFRNTERGALLTTHY 1437
Query: 723 MDEADLLGDRIAIMAKGELQCCGSSLFLKQKYGAGYHMTLVKEPHCNPEDISQLVHHHVP 782
M EA+ + DR+AIM G L+C GS LK K+G Y + + + E + + P
Sbjct: 1438 MAEAEAVCDRVAIMVSGRLRCIGSIQHLKSKFGKDYLLEMKVKNLAQVEPLHAEILRLFP 1497
Query: 783 NATLESSAGAELSFILPRESTHRFEGLFAKLEKKQKELGIASFGASITTMEEVFLRVGK 841
A + + + + LP E F KLEK ++ + + S +T+E+VFL + K
Sbjct: 1498 QAARQERYSSLMVYKLPVEDVQPLAQAFFKLEKVKQSFDLEEYSLSQSTLEQVFLELSK 1556
Score = 118 bits (296), Expect = 4e-26
Identities = 142/610 (23%), Positives = 247/610 (40%), Gaps = 111/610 (18%)
Query: 1105 LFAMAFLASTFSILA---VSERAVQAKHVQFVSGVHVASFWLS-ALLWDLISFLIPSLLL 1160
LF+ S+F A V+ + K + + G+ ++FWLS LL+ F++ L
Sbjct: 226 LFSCIISFSSFIYYASVNVTRERKRMKALMTMMGLRDSAFWLSWGLLYAGFIFIMALFLA 285
Query: 1161 LVVFKAFDVRAFTRDGHMADTLLLLLLYGWAIIPLMYLMNFFFLGAATAYTRLTIFNILS 1220
LV+ + G M L LLYG +++ L +LM+ L + L+
Sbjct: 286 LVIRST---QFIILSGFMV-VFSLFLLYGLSLVALAFLMSI-----------LVKKSFLT 330
Query: 1221 GIATFLMVTIMRIPAVK--LEELSKTLDHVFLVLPNHC--LGMAVSSFYENYETRRYCTS 1276
G+ FL+ L +L+ + +L LGMA + Y +
Sbjct: 331 GLVVFLLTVFWGCLGFTSLYRHLPASLEWILSLLSPFAFMLGMAQLLHLD------YDLN 384
Query: 1277 SEVAAHYCKKYNIQYQENFYAWSAPGVGRFVASMAASGCAYLILLFLIETNL-------- 1328
S H N+ NF +A C YL L E L
Sbjct: 385 SNAFPHPSDGSNLIVATNFM-------------LAFDTCLYLALAIYFEKILPNEYGHRR 431
Query: 1329 --LQRLRGILCALRRRRTLTELYTRMPVLPEDQDVADERTRILAPSPDSLLHTPLIIKEL 1386
L L+ + ++ L M P D ++ AP P+ + I+ +
Sbjct: 432 PPLFFLKSSFWSQTQKTDHVALEDEMDADPSFHDSFEQ-----AP-PEFQGKEAIRIRNV 485
Query: 1387 SKVYEQRVPLL-AVDRLSLAVQKGECFGLLGFNGAGKTTTFKMLTGEESLTSGDAFVGGH 1445
+K Y+ + + A+ L + +G+ +LG +GAGK+T +L+G T G + +
Sbjct: 486 TKEYKGKPDKIEALKDLVFDIYEGQITAILGHSGAGKSTLLNILSGLSVPTKGSVTIYNN 545
Query: 1446 RIS--SDVGKVRQRIGYCPQFDALLDHMTGREMLVMYARLRGIPERHIGACVENTLRGLL 1503
++S +D+ + + G CPQ + D +T RE L ++A+++GI + +
Sbjct: 546 KLSEMADLENLSKLTGVCPQSNVQFDFLTVRENLRLFAKIKGILPQEV------------ 593
Query: 1504 LEPHANKLVRTYSGGNKRKLSTGIALIGEPAVIFLDEPSTGMDPVARRLLWDTVARARES 1563
+ + LDEP+ G+DP +R +W+ + + R++
Sbjct: 594 ----------------------------DKEIFLLDEPTAGLDPFSRHQVWNLL-KERKT 624
Query: 1564 GKAIIITSHSMEECEALCTRLAIMVQGQFKCLGSPQHLKSKFGSGYSLRAKVQSEGQQEA 1623
+ I+ ++ M+E + L R + QG+ KC GS LK K+G GY L ++ +
Sbjct: 625 DRVILFSTQFMDEADILADRKVFLSQGKLKCAGSSLFLKKKWGIGYHLSLQLNEICVE-- 682
Query: 1624 LEEFKAFVDLTFPGSVLEDEHQGMVHYHLPGRDLSWAKVFGILEKAKEKY---GVDDYSV 1680
E + V P + L + +G + Y LP L F L K + Y G+++Y V
Sbjct: 683 -ENITSLVKQHIPDAKLSAKSEGKLIYTLP---LERTNKFPELYKDLDSYPDLGIENYGV 738
Query: 1681 SQISLEQVFL 1690
S +L +VFL
Sbjct: 739 SMTTLNEVFL 748
>gi|169210363 PREDICTED: similar to hCG18626 [Homo sapiens]
Length = 171
Score = 218 bits (554), Expect = 5e-56
Identities = 108/167 (64%), Positives = 132/167 (79%), Gaps = 3/167 (1%)
Query: 1471 MTGREMLVMYARLRGIPERHIGACVENTLRGLLLEPHANKLVRTYSGGNKRKLSTGIALI 1530
MT +E+++MYAR+ G+ E IG V L L LE HA +L+ TYS GNKR+LST IAL+
Sbjct: 1 MTAQEIMIMYARIWGVSEPQIGLYVNKCLNSLELESHAARLINTYSEGNKRRLSTAIALM 60
Query: 1531 GEPAVIFLDEPSTGMDPVARRLLWDTVARARESGKAIIITSHSMEECEALCTRLAIMVQG 1590
G +VIFLDEPSTGMDPVARRLLW+ V + RESGKAI++TSHSMEEC+ALCT LAIMVQG
Sbjct: 61 GRSSVIFLDEPSTGMDPVARRLLWNMVTKTRESGKAIVMTSHSMEECDALCTSLAIMVQG 120
Query: 1591 QFKCLGSPQHLKSKFGSGYSLRAKVQSEGQQEALEEFKAFVDLTFPG 1637
+F CLGSPQHLKSKFG+ Y L+ KV++E + LE+FK +V TFPG
Sbjct: 121 KFTCLGSPQHLKSKFGNIYILKVKVKTE---DKLEDFKCYVATTFPG 164
Score = 94.0 bits (232), Expect = 1e-18
Identities = 51/139 (36%), Positives = 83/139 (59%), Gaps = 1/139 (0%)
Query: 621 LTVAEHLYFYAQLKGLSRQKCPEEVKQMLHIIGLEDKWNSRSRFLSGGMRRKLSIGIALI 680
+T E + YA++ G+S + V + L+ + LE S G +R+LS IAL+
Sbjct: 1 MTAQEIMIMYARIWGVSEPQIGLYVNKCLNSLELESHAARLINTYSEGNKRRLSTAIALM 60
Query: 681 AGSKVLILDEPTSGMDAISRRAIWDLLQR-QKSDRTIVLTTHFMDEADLLGDRIAIMAKG 739
S V+ LDEP++GMD ++RR +W+++ + ++S + IV+T+H M+E D L +AIM +G
Sbjct: 61 GRSSVIFLDEPSTGMDPVARRLLWNMVTKTRESGKAIVMTSHSMEECDALCTSLAIMVQG 120
Query: 740 ELQCCGSSLFLKQKYGAGY 758
+ C GS LK K+G Y
Sbjct: 121 KFTCLGSPQHLKSKFGNIY 139
>gi|169210679 PREDICTED: similar to hCG18626 [Homo sapiens]
Length = 171
Score = 218 bits (554), Expect = 5e-56
Identities = 108/167 (64%), Positives = 132/167 (79%), Gaps = 3/167 (1%)
Query: 1471 MTGREMLVMYARLRGIPERHIGACVENTLRGLLLEPHANKLVRTYSGGNKRKLSTGIALI 1530
MT +E+++MYAR+ G+ E IG V L L LE HA +L+ TYS GNKR+LST IAL+
Sbjct: 1 MTAQEIMIMYARIWGVSEPQIGLYVNKCLNSLELESHAARLINTYSEGNKRRLSTAIALM 60
Query: 1531 GEPAVIFLDEPSTGMDPVARRLLWDTVARARESGKAIIITSHSMEECEALCTRLAIMVQG 1590
G +VIFLDEPSTGMDPVARRLLW+ V + RESGKAI++TSHSMEEC+ALCT LAIMVQG
Sbjct: 61 GRSSVIFLDEPSTGMDPVARRLLWNMVTKTRESGKAIVMTSHSMEECDALCTSLAIMVQG 120
Query: 1591 QFKCLGSPQHLKSKFGSGYSLRAKVQSEGQQEALEEFKAFVDLTFPG 1637
+F CLGSPQHLKSKFG+ Y L+ KV++E + LE+FK +V TFPG
Sbjct: 121 KFTCLGSPQHLKSKFGNIYILKVKVKTE---DKLEDFKCYVATTFPG 164
Score = 94.0 bits (232), Expect = 1e-18
Identities = 51/139 (36%), Positives = 83/139 (59%), Gaps = 1/139 (0%)
Query: 621 LTVAEHLYFYAQLKGLSRQKCPEEVKQMLHIIGLEDKWNSRSRFLSGGMRRKLSIGIALI 680
+T E + YA++ G+S + V + L+ + LE S G +R+LS IAL+
Sbjct: 1 MTAQEIMIMYARIWGVSEPQIGLYVNKCLNSLELESHAARLINTYSEGNKRRLSTAIALM 60
Query: 681 AGSKVLILDEPTSGMDAISRRAIWDLLQR-QKSDRTIVLTTHFMDEADLLGDRIAIMAKG 739
S V+ LDEP++GMD ++RR +W+++ + ++S + IV+T+H M+E D L +AIM +G
Sbjct: 61 GRSSVIFLDEPSTGMDPVARRLLWNMVTKTRESGKAIVMTSHSMEECDALCTSLAIMVQG 120
Query: 740 ELQCCGSSLFLKQKYGAGY 758
+ C GS LK K+G Y
Sbjct: 121 KFTCLGSPQHLKSKFGNIY 139
>gi|169209894 PREDICTED: similar to hCG18626 [Homo sapiens]
Length = 171
Score = 218 bits (554), Expect = 5e-56
Identities = 108/167 (64%), Positives = 132/167 (79%), Gaps = 3/167 (1%)
Query: 1471 MTGREMLVMYARLRGIPERHIGACVENTLRGLLLEPHANKLVRTYSGGNKRKLSTGIALI 1530
MT +E+++MYAR+ G+ E IG V L L LE HA +L+ TYS GNKR+LST IAL+
Sbjct: 1 MTAQEIMIMYARIWGVSEPQIGLYVNKCLNSLELESHAARLINTYSEGNKRRLSTAIALM 60
Query: 1531 GEPAVIFLDEPSTGMDPVARRLLWDTVARARESGKAIIITSHSMEECEALCTRLAIMVQG 1590
G +VIFLDEPSTGMDPVARRLLW+ V + RESGKAI++TSHSMEEC+ALCT LAIMVQG
Sbjct: 61 GRSSVIFLDEPSTGMDPVARRLLWNMVTKTRESGKAIVMTSHSMEECDALCTSLAIMVQG 120
Query: 1591 QFKCLGSPQHLKSKFGSGYSLRAKVQSEGQQEALEEFKAFVDLTFPG 1637
+F CLGSPQHLKSKFG+ Y L+ KV++E + LE+FK +V TFPG
Sbjct: 121 KFTCLGSPQHLKSKFGNIYILKVKVKTE---DKLEDFKCYVATTFPG 164
Score = 94.0 bits (232), Expect = 1e-18
Identities = 51/139 (36%), Positives = 83/139 (59%), Gaps = 1/139 (0%)
Query: 621 LTVAEHLYFYAQLKGLSRQKCPEEVKQMLHIIGLEDKWNSRSRFLSGGMRRKLSIGIALI 680
+T E + YA++ G+S + V + L+ + LE S G +R+LS IAL+
Sbjct: 1 MTAQEIMIMYARIWGVSEPQIGLYVNKCLNSLELESHAARLINTYSEGNKRRLSTAIALM 60
Query: 681 AGSKVLILDEPTSGMDAISRRAIWDLLQR-QKSDRTIVLTTHFMDEADLLGDRIAIMAKG 739
S V+ LDEP++GMD ++RR +W+++ + ++S + IV+T+H M+E D L +AIM +G
Sbjct: 61 GRSSVIFLDEPSTGMDPVARRLLWNMVTKTRESGKAIVMTSHSMEECDALCTSLAIMVQG 120
Query: 740 ELQCCGSSLFLKQKYGAGY 758
+ C GS LK K+G Y
Sbjct: 121 KFTCLGSPQHLKSKFGNIY 139
>gi|11967971 ATP-binding cassette sub-family G member 8 [Homo
sapiens]
Length = 673
Score = 90.9 bits (224), Expect = 1e-17
Identities = 72/230 (31%), Positives = 114/230 (49%), Gaps = 16/230 (6%)
Query: 543 NKDRAAVRDLNLNLYEGQITVLLGHNGAGKTTTLSMLTGLFPP---TSGRAYISGYEISQ 599
N +++L+ + GQ+ ++G +G G+ + L ++TG SG+ +I+G S
Sbjct: 82 NSCELGIQNLSFKVRSGQMLAIIGSSGCGRASLLDVITGRGHGGKIKSGQIWINGQPSSP 141
Query: 600 DMVQIRKSLGLCPQHDILFDNLTVAEHLYFYAQLK------GLSRQKCPEEVKQMLHIIG 653
+V RK + QH+ L NLTV E L F AQ++ R K E+V L +
Sbjct: 142 QLV--RKCVAHVRQHNQLLPNLTVRETLAFIAQMRLPRTFSQAQRDKRVEDVIAELRLRQ 199
Query: 654 LEDK--WNSRSRFLSGGMRRKLSIGIALIAGSKVLILDEPTSGMDAISRRAIWDLLQRQK 711
D N R LSGG RR++SIG+ L+ +LILDEPTSG+D+ + + L R
Sbjct: 200 CADTRVGNMYVRGLSGGERRRVSIGVQLLWNPGILILDEPTSGLDSFTAHNLVKTLSRLA 259
Query: 712 SDRTIVLTTHFMDEADL--LGDRIAIMAKGELQCCGSSLFLKQKYGA-GY 758
+VL + +D+ L D + +M G G++ + Q + A GY
Sbjct: 260 KGNRLVLISLHQPRSDIFRLFDLVLLMTSGTPIYLGAAQHMVQYFTAIGY 309
Score = 87.0 bits (214), Expect = 1e-16
Identities = 62/222 (27%), Positives = 109/222 (49%), Gaps = 16/222 (7%)
Query: 1397 LAVDRLSLAVQKGECFGLLGFNGAGKTTTFKMLTGEE---SLTSGDAFVGGHRISSDVGK 1453
L + LS V+ G+ ++G +G G+ + ++TG + SG ++ G S +
Sbjct: 86 LGIQNLSFKVRSGQMLAIIGSSGCGRASLLDVITGRGHGGKIKSGQIWINGQPSSPQL-- 143
Query: 1454 VRQRIGYCPQFDALLDHMTGREMLVMYARLRGIPERHIGAC----VENTLRGLLLEPHA- 1508
VR+ + + Q + LL ++T RE L A++R +P A VE+ + L L A
Sbjct: 144 VRKCVAHVRQHNQLLPNLTVRETLAFIAQMR-LPRTFSQAQRDKRVEDVIAELRLRQCAD 202
Query: 1509 ----NKLVRTYSGGNKRKLSTGIALIGEPAVIFLDEPSTGMDPVARRLLWDTVARARESG 1564
N VR SGG +R++S G+ L+ P ++ LDEP++G+D L T++R +
Sbjct: 203 TRVGNMYVRGLSGGERRRVSIGVQLLWNPGILILDEPTSGLDSFTAHNLVKTLSRLAKGN 262
Query: 1565 KAIIITSHS-MEECEALCTRLAIMVQGQFKCLGSPQHLKSKF 1605
+ ++I+ H + L + +M G LG+ QH+ F
Sbjct: 263 RLVLISLHQPRSDIFRLFDLVLLMTSGTPIYLGAAQHMVQYF 304
>gi|171184400 ATP-binding cassette, sub-family B, member 10 [Homo
sapiens]
Length = 738
Score = 90.9 bits (224), Expect = 1e-17
Identities = 62/225 (27%), Positives = 116/225 (51%), Gaps = 11/225 (4%)
Query: 550 RDLNLNLYEGQITVLLGHNGAGKTTTLSMLTGLFPPTSGRAYISGYEISQ-DMVQIRKSL 608
+D +L++ G +T L+G +G+GK+T LS+L L+ P SG + G++I Q + V +R +
Sbjct: 511 QDFSLSIPSGSVTALVGPSGSGKSTVLSLLLRLYDPASGTISLDGHDIRQLNPVWLRSKI 570
Query: 609 GLCPQHDILFDNLTVAEHLYFYA----QLKGLSRQKCPEEVKQMLHIIGLEDKWNS---- 660
G Q ILF + ++AE++ + A + Q+ E + I +N+
Sbjct: 571 GTVSQEPILF-SCSIAENIAYGADDPSSVTAEEIQRVAEVANAVAFIRNFPQGFNTVVGE 629
Query: 661 RSRFLSGGMRRKLSIGIALIAGSKVLILDEPTSGMDAISRRAIWDLLQRQKSDRTIVLTT 720
+ LSGG +++++I AL+ K+L+LDE TS +DA + + + L R RT+++
Sbjct: 630 KGVLLSGGQKQRIAIARALLKNPKILLLDEATSALDAENEYLVQEALDRLMDGRTVLVIA 689
Query: 721 HFMDEADLLGDRIAIMAKGELQCCGSSLFLKQKYGAGYHMTLVKE 765
H + + +A++ +G++ G L K Y + K+
Sbjct: 690 HRLSTIK-NANMVAVLDQGKITEYGKHEELLSKPNGIYRKLMNKQ 733
Score = 50.8 bits (120), Expect = 1e-05
Identities = 59/268 (22%), Positives = 105/268 (39%), Gaps = 19/268 (7%)
Query: 1345 LTELYTRMPVLPEDQDVADERTRILAPSPDSLLHTPLIIKELSKVYEQRVPLLAVDRLSL 1404
L EL R P LP ++ V + L K + Y R + SL
Sbjct: 465 LWELLEREPKLPFNEGVILN---------EKSFQGALEFKNVHFAYPARPEVPIFQDFSL 515
Query: 1405 AVQKGECFGLLGFNGAGKTTTFKMLTGEESLTSGDAFVGGHRISS-DVGKVRQRIGYCPQ 1463
++ G L+G +G+GK+T +L SG + GH I + +R +IG Q
Sbjct: 516 SIPSGSVTALVGPSGSGKSTVLSLLLRLYDPASGTISLDGHDIRQLNPVWLRSKIGTVSQ 575
Query: 1464 FDALLDHMTGREMLVMYARLRGIPERHIGACVE--NTLRGLLLEPHANKLVR-----TYS 1516
L + + I E N + + P V S
Sbjct: 576 EPILFSCSIAENIAYGADDPSSVTAEEIQRVAEVANAVAFIRNFPQGFNTVVGEKGVLLS 635
Query: 1517 GGNKRKLSTGIALIGEPAVIFLDEPSTGMDPVARRLLWDTVARARESGKAIIITSHSMEE 1576
GG K++++ AL+ P ++ LDE ++ +D L+ + + R + G+ +++ +H +
Sbjct: 636 GGQKQRIAIARALLKNPKILLLDEATSALDAENEYLVQEALDRLMD-GRTVLVIAHRLST 694
Query: 1577 CEALCTRLAIMVQGQFKCLGSPQHLKSK 1604
+ +A++ QG+ G + L SK
Sbjct: 695 IKN-ANMVAVLDQGKITEYGKHEELLSK 721
>gi|42741659 ATP-binding cassette, subfamily B, member 1 [Homo
sapiens]
Length = 1280
Score = 90.1 bits (222), Expect = 2e-17
Identities = 62/228 (27%), Positives = 120/228 (52%), Gaps = 10/228 (4%)
Query: 545 DRAAVRDLNLNLYEGQITVLLGHNGAGKTTTLSMLTGLFPPTSGRAYISGYEISQDMVQ- 603
D ++ L+L + +GQ L+G +G GK+T + +L + P +G+ + G EI + VQ
Sbjct: 1049 DIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGKVLLDGKEIKRLNVQW 1108
Query: 604 IRKSLGLCPQHDILFDNLTVAEHLYFYAQLKGLSRQKCPEEVKQM-LH--IIGLEDKWNS 660
+R LG+ Q ILFD ++AE++ + + +S+++ K+ +H I L +K+++
Sbjct: 1109 LRAHLGIVSQEPILFD-CSIAENIAYGDNSRVVSQEEIVRAAKEANIHAFIESLPNKYST 1167
Query: 661 R----SRFLSGGMRRKLSIGIALIAGSKVLILDEPTSGMDAISRRAIWDLLQRQKSDRTI 716
+ LSGG +++++I AL+ +L+LDE TS +D S + + + L + + RT
Sbjct: 1168 KVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTC 1227
Query: 717 VLTTHFMDEADLLGDRIAIMAKGELQCCGSSLFLKQKYGAGYHMTLVK 764
++ H + D I + G ++ G+ L + G + M V+
Sbjct: 1228 IVIAHRLSTIQ-NADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQ 1274
Score = 89.4 bits (220), Expect = 3e-17
Identities = 55/206 (26%), Positives = 111/206 (53%), Gaps = 8/206 (3%)
Query: 522 EPEDLVAGIKIKHLSKVFRVGNKDRAAVRDLNLNLYEGQITVLLGHNGAGKTTTLSMLTG 581
+P+++ ++ +++ + K+ ++ LNL + GQ L+G++G GK+TT+ ++
Sbjct: 384 KPDNIKGNLEFRNVHFSYP-SRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQR 442
Query: 582 LFPPTSGRAYISGYEISQDMVQ-IRKSLGLCPQHDILFDNLTVAEHLYFYAQLKGLSR-Q 639
L+ PT G + G +I V+ +R+ +G+ Q +LF T+AE++ + + + +
Sbjct: 443 LYDPTEGMVSVDGQDIRTINVRFLREIIGVVSQEPVLFAT-TIAENIRYGRENVTMDEIE 501
Query: 640 KCPEEVKQMLHIIGLEDKWNS----RSRFLSGGMRRKLSIGIALIAGSKVLILDEPTSGM 695
K +E I+ L K+++ R LSGG +++++I AL+ K+L+LDE TS +
Sbjct: 502 KAVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSAL 561
Query: 696 DAISRRAIWDLLQRQKSDRTIVLTTH 721
D S + L + + RT ++ H
Sbjct: 562 DTESEAVVQVALDKARKGRTTIVIAH 587
Score = 64.7 bits (156), Expect = 7e-10
Identities = 54/230 (23%), Positives = 104/230 (45%), Gaps = 11/230 (4%)
Query: 1390 YEQRVPLLAVDRLSLAVQKGECFGLLGFNGAGKTTTFKMLTGEESLTSGDAFVGGHRISS 1449
Y R + + LSL V+KG+ L+G +G GK+T ++L +G + G I
Sbjct: 1044 YPTRPDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGKVLLDGKEIKR 1103
Query: 1450 -DVGKVRQRIGYCPQFDALLDHMTGREMLVMYARLRGIPERHIGACVENTLRGLLLEPHA 1508
+V +R +G Q L D E + R + + I + +E
Sbjct: 1104 LNVQWLRAHLGIVSQEPILFDCSIA-ENIAYGDNSRVVSQEEIVRAAKEANIHAFIESLP 1162
Query: 1509 NKLVRTY-------SGGNKRKLSTGIALIGEPAVIFLDEPSTGMDPVARRLLWDTVARAR 1561
NK SGG K++++ AL+ +P ++ LDE ++ +D + +++ + + +AR
Sbjct: 1163 NKYSTKVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAR 1222
Query: 1562 ESGKAIIITSHSMEECEALCTRLAIMVQGQFKCLGSPQHLKSKFGSGYSL 1611
E G+ I+ +H + + + + G+ K G+ Q L ++ G +S+
Sbjct: 1223 E-GRTCIVIAHRLSTIQN-ADLIVVFQNGRVKEHGTHQQLLAQKGIYFSM 1270
Score = 55.1 bits (131), Expect = 6e-07
Identities = 51/197 (25%), Positives = 92/197 (46%), Gaps = 20/197 (10%)
Query: 1390 YEQRVPLLAVDRLSLAVQKGECFGLLGFNGAGKTTTFKMLTGEESLTSGDAFVGGHRISS 1449
Y R + + L+L VQ G+ L+G +G GK+TT +++ T G V G I +
Sbjct: 401 YPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRT 460
Query: 1450 -DVGKVRQRIGYCPQFDALL------DHMTGREMLVMYARLRGIPERHIGACVENTLRGL 1502
+V +R+ IG Q L + GRE + M + + E N +
Sbjct: 461 INVRFLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEA-------NAYDFI 513
Query: 1503 LLEPHA-NKLV----RTYSGGNKRKLSTGIALIGEPAVIFLDEPSTGMDPVARRLLWDTV 1557
+ PH + LV SGG K++++ AL+ P ++ LDE ++ +D + ++ +
Sbjct: 514 MKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQVAL 573
Query: 1558 ARARESGKAIIITSHSM 1574
+AR+ G+ I+ +H +
Sbjct: 574 DKARK-GRTTIVIAHRL 589
>gi|148612844 ATP-binding cassette, sub-family B, member 5 [Homo
sapiens]
Length = 812
Score = 90.1 bits (222), Expect = 2e-17
Identities = 63/233 (27%), Positives = 122/233 (52%), Gaps = 19/233 (8%)
Query: 522 EPEDLVAGIKIKHLSKVFRVGNKDRAAVRDLNLNLYEGQITVLLGHNGAGKTTTLSMLTG 581
+P+ ++ + +S F D +R L+L++ G+ +G +G GK+T++ +L
Sbjct: 562 KPDTCEGNLEFREVS-FFYPCRPDVFILRGLSLSIERGKTVAFVGSSGCGKSTSVQLLQR 620
Query: 582 LFPPTSGRAYISGYEISQDMVQ-IRKSLGLCPQHDILFDNLTVAEHLYFYAQLKGLSRQK 640
L+ P G+ G + + VQ +R + + PQ +LF N ++AE++ + SR
Sbjct: 621 LYDPVQGQVLFDGVDAKELNVQWLRSQIAIVPQEPVLF-NCSIAENIAYGDN----SRVV 675
Query: 641 CPEEVKQMLH-------IIGLEDKWNS----RSRFLSGGMRRKLSIGIALIAGSKVLILD 689
+E+K+ + I GL +K+N+ + LSGG +++L+I AL+ K+L+LD
Sbjct: 676 PLDEIKEAANAANIHSFIEGLPEKYNTQVGLKGAQLSGGQKQRLAIARALLQKPKILLLD 735
Query: 690 EPTSGMDAISRRAIWDLLQRQKSDRTIVLTTHFMDEADLLGDRIAIMAKGELQ 742
E TS +D S + + L + ++ RT ++ TH + A D I ++ G+++
Sbjct: 736 EATSALDNDSEKVVQHALDKARTGRTCLVVTHRL-SAIQNADLIVVLHNGKIK 787
Score = 57.8 bits (138), Expect = 9e-08
Identities = 52/229 (22%), Positives = 111/229 (48%), Gaps = 11/229 (4%)
Query: 1381 LIIKELSKVYEQRVPLLAVDRLSLAVQKGECFGLLGFNGAGKTTTFKMLTGEESLTSGDA 1440
L +E+S Y R + + LSL++++G+ +G +G GK+T+ ++L G
Sbjct: 570 LEFREVSFFYPCRPDVFILRGLSLSIERGKTVAFVGSSGCGKSTSVQLLQRLYDPVQGQV 629
Query: 1441 -FVGGHRISSDVGKVRQRIGYCPQFDALLDHMTGREMLVMYARLRGIPERHI-----GAC 1494
F G +V +R +I PQ + +L + + E + R +P I A
Sbjct: 630 LFDGVDAKELNVQWLRSQIAIVPQ-EPVLFNCSIAENIAYGDNSRVVPLDEIKEAANAAN 688
Query: 1495 VENTLRGLLLEPHANKLVR--TYSGGNKRKLSTGIALIGEPAVIFLDEPSTGMDPVARRL 1552
+ + + GL + + ++ SGG K++L+ AL+ +P ++ LDE ++ +D + ++
Sbjct: 689 IHSFIEGLPEKYNTQVGLKGAQLSGGQKQRLAIARALLQKPKILLLDEATSALDNDSEKV 748
Query: 1553 LWDTVARARESGKAIIITSHSMEECEALCTRLAIMVQGQFKCLGSPQHL 1601
+ + +AR +G+ ++ +H + + + ++ G+ K G+ Q L
Sbjct: 749 VQHALDKAR-TGRTCLVVTHRLSAIQN-ADLIVVLHNGKIKEQGTHQEL 795
Score = 55.8 bits (133), Expect = 3e-07
Identities = 40/165 (24%), Positives = 74/165 (44%), Gaps = 5/165 (3%)
Query: 605 RKSLGLCPQHDILFDNLTVAEHLYFYAQLKGLSRQKCPEEVKQMLHIIGLEDKWNS---- 660
R +G+ Q +LF Y + ++ E I+ +K+N+
Sbjct: 16 RDHIGVVSQEPVLFGTTISNNIKYGRDDVTDEEMERAAREANAYDFIMEFPNKFNTLVGE 75
Query: 661 RSRFLSGGMRRKLSIGIALIAGSKVLILDEPTSGMDAISRRAIWDLLQRQKSDRTIVLTT 720
+ +SGG +++++I AL+ K+LILDE TS +D+ S+ A+ L++ RT ++
Sbjct: 76 KGAQMSGGQKQRIAIARALVRNPKILILDEATSALDSESKSAVQAALEKASKGRTTIVVA 135
Query: 721 HFMDEADLLGDRIAIMAKGELQCCGSSLFLKQKYGAGYHMTLVKE 765
H + D I + G L G+ L K G Y + + ++
Sbjct: 136 HRLSTI-RSADLIVTLKDGMLAEKGAHAELMAKRGLYYSLVMSQD 179
Score = 40.4 bits (93), Expect = 0.015
Identities = 27/114 (23%), Positives = 57/114 (50%), Gaps = 5/114 (4%)
Query: 1516 SGGNKRKLSTGIALIGEPAVIFLDEPSTGMDPVARRLLWDTVARARESGKAIIITSHSME 1575
SGG K++++ AL+ P ++ LDE ++ +D ++ + + +A G+ I+ +H +
Sbjct: 81 SGGQKQRIAIARALVRNPKILILDEATSALDSESKSAVQAALEKA-SKGRTTIVVAHRLS 139
Query: 1576 ECEALCTRLAIMVQGQFKCLGSPQHLKSKFGSGYSLRAKVQSEGQQEALEEFKA 1629
+ + + G G+ L +K G YSL V S+ ++A E+ ++
Sbjct: 140 TIRS-ADLIVTLKDGMLAEKGAHAELMAKRGLYYSL---VMSQDIKKADEQMES 189
>gi|11967969 ATP-binding cassette sub-family G member 5 [Homo
sapiens]
Length = 651
Score = 90.1 bits (222), Expect = 2e-17
Identities = 73/213 (34%), Positives = 112/213 (52%), Gaps = 14/213 (6%)
Query: 546 RAAVRDLNLNLYEGQITVLLGHNGAGKTTTLSMLTGLFPPTS---GRAYISGYEISQDMV 602
R ++D++L + GQI +LG +G+GKTT L ++G G Y++G + ++
Sbjct: 66 RQILKDVSLYVESGQIMCILGSSGSGKTTLLDAMSGRLGRAGTFLGEVYVNGRALRREQF 125
Query: 603 QIRKSLGLCPQHDILFDNLTVAEHLYFYAQL-----KGLSRQKCPEEVKQMLHIIGLEDK 657
Q S L Q D L +LTV E L++ A L S QK E V L + + D+
Sbjct: 126 QDCFSYVL--QSDTLLSSLTVRETLHYTALLAIRRGNPGSFQKKVEAVMAELSLSHVADR 183
Query: 658 W--NSRSRFLSGGMRRKLSIGIALIAGSKVLILDEPTSGMDAISRRAIWDLL-QRQKSDR 714
N +S G RR++SI L+ KV++ DEPT+G+D ++ I LL + + +R
Sbjct: 184 LIGNYSLGGISTGERRRVSIAAQLLQDPKVMLFDEPTTGLDCMTANQIVVLLVELARRNR 243
Query: 715 TIVLTTHF-MDEADLLGDRIAIMAKGELQCCGS 746
+VLT H E L D+IAI++ GEL CG+
Sbjct: 244 IVVLTIHQPRSELFQLFDKIAILSFGELIFCGT 276
Score = 72.8 bits (177), Expect = 3e-12
Identities = 60/221 (27%), Positives = 102/221 (46%), Gaps = 16/221 (7%)
Query: 1402 LSLAVQKGECFGLLGFNGAGKTTTFKMLTGEESLTS---GDAFVGGHRISSDVGKVRQRI 1458
+SL V+ G+ +LG +G+GKTT ++G G+ +V G + + + +
Sbjct: 72 VSLYVESGQIMCILGSSGSGKTTLLDAMSGRLGRAGTFLGEVYVNGRALRRE--QFQDCF 129
Query: 1459 GYCPQFDALLDHMTGREMLVMYARLRGIPERHIGAC---VENTLRGLLLEPHANKLVRTY 1515
Y Q D LL +T RE L Y L I + G+ VE + L L A++L+ Y
Sbjct: 130 SYVLQSDTLLSSLTVRETL-HYTALLAIRRGNPGSFQKKVEAVMAELSLSHVADRLIGNY 188
Query: 1516 S-----GGNKRKLSTGIALIGEPAVIFLDEPSTGMDPVARRLLWDTVARARESGKAIIIT 1570
S G +R++S L+ +P V+ DEP+TG+D + + + + +++T
Sbjct: 189 SLGGISTGERRRVSIAAQLLQDPKVMLFDEPTTGLDCMTANQIVVLLVELARRNRIVVLT 248
Query: 1571 SHS-MEECEALCTRLAIMVQGQFKCLGSPQHLKSKFGS-GY 1609
H E L ++AI+ G+ G+P + F GY
Sbjct: 249 IHQPRSELFQLFDKIAILSFGELIFCGTPAEMLDFFNDCGY 289
>gi|21536378 ATP-binding cassette, sub-family B (MDR/TAP), member 11
[Homo sapiens]
Length = 1321
Score = 86.7 bits (213), Expect = 2e-16
Identities = 59/230 (25%), Positives = 117/230 (50%), Gaps = 10/230 (4%)
Query: 545 DRAAVRDLNLNLYEGQITVLLGHNGAGKTTTLSMLTGLFPPTSGRAYISGYEISQDMVQ- 603
D + L++++ GQ +G +G GK+T++ +L + P G+ I G++ + VQ
Sbjct: 1092 DSQVLNGLSVSISPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGKVMIDGHDSKKVNVQF 1151
Query: 604 IRKSLGLCPQHDILFDNLTVAEHLYFYAQLKGLSRQKCPEEVKQ-MLH--IIGLEDKWN- 659
+R ++G+ Q +LF ++ +++ + K + ++ KQ LH ++ L +K+
Sbjct: 1152 LRSNIGIVSQEPVLFA-CSIMDNIKYGDNTKEIPMERVIAAAKQAQLHDFVMSLPEKYET 1210
Query: 660 ---SRSRFLSGGMRRKLSIGIALIAGSKVLILDEPTSGMDAISRRAIWDLLQRQKSDRTI 716
S+ LS G +++++I A++ K+L+LDE TS +D S + + L + + RT
Sbjct: 1211 NVGSQGSQLSRGEKQRIAIARAIVRDPKILLLDEATSALDTESEKTVQVALDKAREGRTC 1270
Query: 717 VLTTHFMDEADLLGDRIAIMAKGELQCCGSSLFLKQKYGAGYHMTLVKEP 766
++ H + D IA+MA+G + G+ L + GA Y + P
Sbjct: 1271 IVIAHRLSTIQ-NADIIAVMAQGVVIEKGTHEELMAQKGAYYKLVTTGSP 1319
Score = 77.4 bits (189), Expect = 1e-13
Identities = 48/179 (26%), Positives = 96/179 (53%), Gaps = 7/179 (3%)
Query: 549 VRDLNLNLYEGQITVLLGHNGAGKTTTLSMLTGLFPPTSGRAYISGYEISQDMVQ-IRKS 607
+ DLN+ + G++T L+G +GAGK+T L ++ + P G + G++I +Q +R
Sbjct: 438 LNDLNMVIKPGEMTALVGPSGAGKSTALQLIQRFYDPCEGMVTVDGHDIRSLNIQWLRDQ 497
Query: 608 LGLCPQHDILFDNLTVAEHLYFYAQLKGLSR-QKCPEEVKQMLHIIGLEDKWNS----RS 662
+G+ Q +LF + T+AE++ + + + + +E I+ L ++++
Sbjct: 498 IGIVEQEPVLF-STTIAENIRYGREDATMEDIVQAAKEANAYNFIMDLPQQFDTLVGEGG 556
Query: 663 RFLSGGMRRKLSIGIALIAGSKVLILDEPTSGMDAISRRAIWDLLQRQKSDRTIVLTTH 721
+SGG +++++I ALI K+L+LD TS +D S + ++L + + TI+ H
Sbjct: 557 GQMSGGQKQRVAIARALIRNPKILLLDMATSALDNESEAMVQEVLSKIQHGHTIISVAH 615
Score = 60.1 bits (144), Expect = 2e-08
Identities = 52/230 (22%), Positives = 106/230 (46%), Gaps = 11/230 (4%)
Query: 1390 YEQRVPLLAVDRLSLAVQKGECFGLLGFNGAGKTTTFKMLTGEESLTSGDAFVGGHRISS 1449
Y R ++ LS+++ G+ +G +G GK+T+ ++L G + GH
Sbjct: 1087 YPSRPDSQVLNGLSVSISPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGKVMIDGHDSKK 1146
Query: 1450 -DVGKVRQRIGYCPQFDALLDHMTGREMLVMYARLRGIP-ERHIGACVENTLRGLLL--- 1504
+V +R IG Q + +L + + + + IP ER I A + L ++
Sbjct: 1147 VNVQFLRSNIGIVSQ-EPVLFACSIMDNIKYGDNTKEIPMERVIAAAKQAQLHDFVMSLP 1205
Query: 1505 ---EPHANKLVRTYSGGNKRKLSTGIALIGEPAVIFLDEPSTGMDPVARRLLWDTVARAR 1561
E + S G K++++ A++ +P ++ LDE ++ +D + + + + +AR
Sbjct: 1206 EKYETNVGSQGSQLSRGEKQRIAIARAIVRDPKILLLDEATSALDTESEKTVQVALDKAR 1265
Query: 1562 ESGKAIIITSHSMEECEALCTRLAIMVQGQFKCLGSPQHLKSKFGSGYSL 1611
E G+ I+ +H + + +A+M QG G+ + L ++ G+ Y L
Sbjct: 1266 E-GRTCIVIAHRLSTIQN-ADIIAVMAQGVVIEKGTHEELMAQKGAYYKL 1313
Score = 58.2 bits (139), Expect = 7e-08
Identities = 58/244 (23%), Positives = 108/244 (44%), Gaps = 12/244 (4%)
Query: 1390 YEQRVPLLAVDRLSLAVQKGECFGLLGFNGAGKTTTFKMLTGEESLTSGDAFVGGHRISS 1449
Y R + ++ L++ ++ GE L+G +GAGK+T +++ G V GH I S
Sbjct: 429 YPSRPEVKILNDLNMVIKPGEMTALVGPSGAGKSTALQLIQRFYDPCEGMVTVDGHDIRS 488
Query: 1450 -DVGKVRQRIGYCPQFDALLDHMTGREMLVMYARLRGIPERHIGACVENTLRGLLLE--P 1506
++ +R +IG Q L + Y R E + A E +++
Sbjct: 489 LNIQWLRDQIGIVEQEPVLFSTTIAEN--IRYGREDATMEDIVQAAKEANAYNFIMDLPQ 546
Query: 1507 HANKLV----RTYSGGNKRKLSTGIALIGEPAVIFLDEPSTGMDPVARRLLWDTVARARE 1562
+ LV SGG K++++ ALI P ++ LD ++ +D + ++ + +++ +
Sbjct: 547 QFDTLVGEGGGQMSGGQKQRVAIARALIRNPKILLLDMATSALDNESEAMVQEVLSKI-Q 605
Query: 1563 SGKAIIITSHSMEECEALCTRLAIMVQGQFKCLGSPQHLKSKFGSGYSLRAKVQSEGQQE 1622
G II +H + A T + G G+ + L + G ++L +QS+G Q
Sbjct: 606 HGHTIISVAHRLSTVRAADTIIG-FEHGTAVERGTHEELLERKGVYFTL-VTLQSQGNQA 663
Query: 1623 ALEE 1626
EE
Sbjct: 664 LNEE 667
>gi|9961250 ATP-binding cassette, subfamily B, member 4 isoform B
[Homo sapiens]
Length = 1286
Score = 85.9 bits (211), Expect = 3e-16
Identities = 63/218 (28%), Positives = 108/218 (49%), Gaps = 8/218 (3%)
Query: 549 VRDLNLNLYEGQITVLLGHNGAGKTTTLSMLTGLFPPTSGRAYISGYEISQDMVQ-IRKS 607
++ LNL + GQ L+G +G GK+TT+ ++ L+ P G I G +I V +R+
Sbjct: 412 LKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREI 471
Query: 608 LGLCPQHDILFDNLTVAEHL-YFYAQLKGLSRQKCPEEVKQMLHIIGLEDKWNS----RS 662
+G+ Q +LF T+AE++ Y + +K +E I+ L K+++ R
Sbjct: 472 IGVVSQEPVLFST-TIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERG 530
Query: 663 RFLSGGMRRKLSIGIALIAGSKVLILDEPTSGMDAISRRAIWDLLQRQKSDRTIVLTTHF 722
LSGG +++++I AL+ K+L+LDE TS +D S + L + + RT ++ H
Sbjct: 531 AQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHR 590
Query: 723 MDEADLLGDRIAIMAKGELQCCGSSLFLKQKYGAGYHM 760
+ D IA G + GS L +K G + +
Sbjct: 591 LSTV-RNADVIAGFEDGVIVEQGSHSELMKKEGVYFKL 627
Score = 80.9 bits (198), Expect = 1e-14
Identities = 72/274 (26%), Positives = 128/274 (46%), Gaps = 27/274 (9%)
Query: 507 DSDPEKALRNEYFEAEPEDLVAGIKIKHLSKVFRVGNKDRAAV-RDLNLNLYEGQITVLL 565
DS E+ L+ + FE I VF + V + L+L + +GQ L+
Sbjct: 1018 DSYSEEGLKPDKFEGN---------ITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALV 1068
Query: 566 GHNGAGKTTTLSMLTGLFPPTSGRAYIS-------GYEISQDMVQ-IRKSLGLCPQHDIL 617
G +G GK+T + +L + P +G ++ G E + VQ +R LG+ Q IL
Sbjct: 1069 GSSGCGKSTVVQLLERFYDPLAGTVFVDFGFQLLDGQEAKKLNVQWLRAQLGIVSQEPIL 1128
Query: 618 FDNLTVAEHLYFYAQLKGLSRQKCPEEVKQM-LH--IIGLEDKWNSR----SRFLSGGMR 670
FD ++AE++ + + +S+ + K +H I L K+ +R LSGG +
Sbjct: 1129 FD-CSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQK 1187
Query: 671 RKLSIGIALIAGSKVLILDEPTSGMDAISRRAIWDLLQRQKSDRTIVLTTHFMDEADLLG 730
++++I ALI ++L+LDE TS +D S + + + L + + RT ++ H +
Sbjct: 1188 QRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQ-NA 1246
Query: 731 DRIAIMAKGELQCCGSSLFLKQKYGAGYHMTLVK 764
D I + G ++ G+ L + G + M V+
Sbjct: 1247 DLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQ 1280
Score = 60.8 bits (146), Expect = 1e-08
Identities = 56/241 (23%), Positives = 107/241 (44%), Gaps = 26/241 (10%)
Query: 1390 YEQRVPLLAVDRLSLAVQKGECFGLLGFNGAGKTTTFKMLTGEESLTSGDAFV------- 1442
Y R + + LSL V+KG+ L+G +G GK+T ++L +G FV
Sbjct: 1043 YPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVFVDFGFQLL 1102
Query: 1443 -GGHRISSDVGKVRQRIGYCPQFDALLDHMTGREMLVMYARLRGIPERHIGACVENTLRG 1501
G +V +R ++G Q L D + E + R + + I + +
Sbjct: 1103 DGQEAKKLNVQWLRAQLGIVSQEPILFD-CSIAENIAYGDNSRVVSQDEI----VSAAKA 1157
Query: 1502 LLLEPHANKLVRTY-----------SGGNKRKLSTGIALIGEPAVIFLDEPSTGMDPVAR 1550
+ P L Y SGG K++++ ALI +P ++ LDE ++ +D +
Sbjct: 1158 ANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESE 1217
Query: 1551 RLLWDTVARARESGKAIIITSHSMEECEALCTRLAIMVQGQFKCLGSPQHLKSKFGSGYS 1610
+++ + + +ARE G+ I+ +H + + + + G+ K G+ Q L ++ G +S
Sbjct: 1218 KVVQEALDKARE-GRTCIVIAHRLSTIQN-ADLIVVFQNGRVKEHGTHQQLLAQKGIYFS 1275
Query: 1611 L 1611
+
Sbjct: 1276 M 1276
Score = 57.0 bits (136), Expect = 2e-07
Identities = 64/263 (24%), Positives = 110/263 (41%), Gaps = 13/263 (4%)
Query: 1373 PDSLLHTPLIIKELSKVYEQRVPLLAVDRLSLAVQKGECFGLLGFNGAGKTTTFKMLTGE 1432
PDS+ L ++ Y R + + L+L VQ G+ L+G +G GK+TT +++
Sbjct: 387 PDSIKGN-LEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRL 445
Query: 1433 ESLTSGDAFVGGHRISS-DVGKVRQRIGYCPQFDALLDHMTGREMLVMYARLRGIPERHI 1491
G + G I + +V +R+ IG Q L + Y R +
Sbjct: 446 YDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAEN--ICYGRGNVTMDEIK 503
Query: 1492 GACVE-NTLRGLLLEPH-----ANKLVRTYSGGNKRKLSTGIALIGEPAVIFLDEPSTGM 1545
A E N ++ P + SGG K++++ AL+ P ++ LDE ++ +
Sbjct: 504 KAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSAL 563
Query: 1546 DPVARRLLWDTVARARESGKAIIITSHSMEECEALCTRLAIMVQGQFKCLGSPQHLKSKF 1605
D + + + +ARE G+ I+ +H + +A G GS L K
Sbjct: 564 DTESEAEVQAALDKARE-GRTTIVIAHRLSTVRN-ADVIAGFEDGVIVEQGSHSELMKKE 621
Query: 1606 GSGYSLRAKVQSEGQQEALEEFK 1628
G + L +Q+ G Q EEF+
Sbjct: 622 GVYFKL-VNMQTSGSQIQSEEFE 643
>gi|9961252 ATP-binding cassette, subfamily B, member 4 isoform C
[Homo sapiens]
Length = 1232
Score = 85.9 bits (211), Expect = 3e-16
Identities = 63/218 (28%), Positives = 108/218 (49%), Gaps = 8/218 (3%)
Query: 549 VRDLNLNLYEGQITVLLGHNGAGKTTTLSMLTGLFPPTSGRAYISGYEISQDMVQ-IRKS 607
++ LNL + GQ L+G +G GK+TT+ ++ L+ P G I G +I V +R+
Sbjct: 412 LKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREI 471
Query: 608 LGLCPQHDILFDNLTVAEHL-YFYAQLKGLSRQKCPEEVKQMLHIIGLEDKWNS----RS 662
+G+ Q +LF T+AE++ Y + +K +E I+ L K+++ R
Sbjct: 472 IGVVSQEPVLFST-TIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERG 530
Query: 663 RFLSGGMRRKLSIGIALIAGSKVLILDEPTSGMDAISRRAIWDLLQRQKSDRTIVLTTHF 722
LSGG +++++I AL+ K+L+LDE TS +D S + L + + RT ++ H
Sbjct: 531 AQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHR 590
Query: 723 MDEADLLGDRIAIMAKGELQCCGSSLFLKQKYGAGYHM 760
+ D IA G + GS L +K G + +
Sbjct: 591 LSTV-RNADVIAGFEDGVIVEQGSHSELMKKEGVYFKL 627
Score = 85.9 bits (211), Expect = 3e-16
Identities = 72/267 (26%), Positives = 127/267 (47%), Gaps = 20/267 (7%)
Query: 507 DSDPEKALRNEYFEAEPEDLVAGIKIKHLSKVFRVGNKDRAAV-RDLNLNLYEGQITVLL 565
DS E+ L+ + FE I VF + V + L+L + +GQ L+
Sbjct: 971 DSYSEEGLKPDKFEGN---------ITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALV 1021
Query: 566 GHNGAGKTTTLSMLTGLFPPTSGRAYISGYEISQDMVQ-IRKSLGLCPQHDILFDNLTVA 624
G +G GK+T + +L + P +G + G E + VQ +R LG+ Q ILFD ++A
Sbjct: 1022 GSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFD-CSIA 1080
Query: 625 EHLYFYAQLKGLSRQKCPEEVKQM-LH--IIGLEDKWNSR----SRFLSGGMRRKLSIGI 677
E++ + + +S+ + K +H I L K+ +R LSGG +++++I
Sbjct: 1081 ENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIAR 1140
Query: 678 ALIAGSKVLILDEPTSGMDAISRRAIWDLLQRQKSDRTIVLTTHFMDEADLLGDRIAIMA 737
ALI ++L+LDE TS +D S + + + L + + RT ++ H + D I +
Sbjct: 1141 ALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQ-NADLIVVFQ 1199
Query: 738 KGELQCCGSSLFLKQKYGAGYHMTLVK 764
G ++ G+ L + G + M V+
Sbjct: 1200 NGRVKEHGTHQQLLAQKGIYFSMVSVQ 1226
Score = 62.4 bits (150), Expect = 4e-09
Identities = 54/234 (23%), Positives = 105/234 (44%), Gaps = 19/234 (8%)
Query: 1390 YEQRVPLLAVDRLSLAVQKGECFGLLGFNGAGKTTTFKMLTGEESLTSGDAFVGGHRISS 1449
Y R + + LSL V+KG+ L+G +G GK+T ++L +G + G
Sbjct: 996 YPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKK 1055
Query: 1450 -DVGKVRQRIGYCPQFDALLDHMTGREMLVMYARLRGIPERHIGACVENTLRGLLLEPHA 1508
+V +R ++G Q L D E + R + + I + + + P
Sbjct: 1056 LNVQWLRAQLGIVSQEPILFDCSIA-ENIAYGDNSRVVSQDEIVSAA----KAANIHPFI 1110
Query: 1509 NKLVRTY-----------SGGNKRKLSTGIALIGEPAVIFLDEPSTGMDPVARRLLWDTV 1557
L Y SGG K++++ ALI +P ++ LDE ++ +D + +++ + +
Sbjct: 1111 ETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEAL 1170
Query: 1558 ARARESGKAIIITSHSMEECEALCTRLAIMVQGQFKCLGSPQHLKSKFGSGYSL 1611
+ARE G+ I+ +H + + + + G+ K G+ Q L ++ G +S+
Sbjct: 1171 DKARE-GRTCIVIAHRLSTIQN-ADLIVVFQNGRVKEHGTHQQLLAQKGIYFSM 1222
Score = 57.0 bits (136), Expect = 2e-07
Identities = 64/263 (24%), Positives = 110/263 (41%), Gaps = 13/263 (4%)
Query: 1373 PDSLLHTPLIIKELSKVYEQRVPLLAVDRLSLAVQKGECFGLLGFNGAGKTTTFKMLTGE 1432
PDS+ L ++ Y R + + L+L VQ G+ L+G +G GK+TT +++
Sbjct: 387 PDSIKGN-LEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRL 445
Query: 1433 ESLTSGDAFVGGHRISS-DVGKVRQRIGYCPQFDALLDHMTGREMLVMYARLRGIPERHI 1491
G + G I + +V +R+ IG Q L + Y R +
Sbjct: 446 YDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAEN--ICYGRGNVTMDEIK 503
Query: 1492 GACVE-NTLRGLLLEPH-----ANKLVRTYSGGNKRKLSTGIALIGEPAVIFLDEPSTGM 1545
A E N ++ P + SGG K++++ AL+ P ++ LDE ++ +
Sbjct: 504 KAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSAL 563
Query: 1546 DPVARRLLWDTVARARESGKAIIITSHSMEECEALCTRLAIMVQGQFKCLGSPQHLKSKF 1605
D + + + +ARE G+ I+ +H + +A G GS L K
Sbjct: 564 DTESEAEVQAALDKARE-GRTTIVIAHRLSTVRN-ADVIAGFEDGVIVEQGSHSELMKKE 621
Query: 1606 GSGYSLRAKVQSEGQQEALEEFK 1628
G + L +Q+ G Q EEF+
Sbjct: 622 GVYFKL-VNMQTSGSQIQSEEFE 643
>gi|4505771 ATP-binding cassette, subfamily B, member 4 isoform A
[Homo sapiens]
Length = 1279
Score = 85.9 bits (211), Expect = 3e-16
Identities = 63/218 (28%), Positives = 108/218 (49%), Gaps = 8/218 (3%)
Query: 549 VRDLNLNLYEGQITVLLGHNGAGKTTTLSMLTGLFPPTSGRAYISGYEISQDMVQ-IRKS 607
++ LNL + GQ L+G +G GK+TT+ ++ L+ P G I G +I V +R+
Sbjct: 412 LKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREI 471
Query: 608 LGLCPQHDILFDNLTVAEHL-YFYAQLKGLSRQKCPEEVKQMLHIIGLEDKWNS----RS 662
+G+ Q +LF T+AE++ Y + +K +E I+ L K+++ R
Sbjct: 472 IGVVSQEPVLFST-TIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERG 530
Query: 663 RFLSGGMRRKLSIGIALIAGSKVLILDEPTSGMDAISRRAIWDLLQRQKSDRTIVLTTHF 722
LSGG +++++I AL+ K+L+LDE TS +D S + L + + RT ++ H
Sbjct: 531 AQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHR 590
Query: 723 MDEADLLGDRIAIMAKGELQCCGSSLFLKQKYGAGYHM 760
+ D IA G + GS L +K G + +
Sbjct: 591 LSTV-RNADVIAGFEDGVIVEQGSHSELMKKEGVYFKL 627
Score = 85.9 bits (211), Expect = 3e-16
Identities = 72/267 (26%), Positives = 127/267 (47%), Gaps = 20/267 (7%)
Query: 507 DSDPEKALRNEYFEAEPEDLVAGIKIKHLSKVFRVGNKDRAAV-RDLNLNLYEGQITVLL 565
DS E+ L+ + FE I VF + V + L+L + +GQ L+
Sbjct: 1018 DSYSEEGLKPDKFEGN---------ITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALV 1068
Query: 566 GHNGAGKTTTLSMLTGLFPPTSGRAYISGYEISQDMVQ-IRKSLGLCPQHDILFDNLTVA 624
G +G GK+T + +L + P +G + G E + VQ +R LG+ Q ILFD ++A
Sbjct: 1069 GSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFD-CSIA 1127
Query: 625 EHLYFYAQLKGLSRQKCPEEVKQM-LH--IIGLEDKWNSR----SRFLSGGMRRKLSIGI 677
E++ + + +S+ + K +H I L K+ +R LSGG +++++I
Sbjct: 1128 ENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIAR 1187
Query: 678 ALIAGSKVLILDEPTSGMDAISRRAIWDLLQRQKSDRTIVLTTHFMDEADLLGDRIAIMA 737
ALI ++L+LDE TS +D S + + + L + + RT ++ H + D I +
Sbjct: 1188 ALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQ-NADLIVVFQ 1246
Query: 738 KGELQCCGSSLFLKQKYGAGYHMTLVK 764
G ++ G+ L + G + M V+
Sbjct: 1247 NGRVKEHGTHQQLLAQKGIYFSMVSVQ 1273
Score = 62.4 bits (150), Expect = 4e-09
Identities = 54/234 (23%), Positives = 105/234 (44%), Gaps = 19/234 (8%)
Query: 1390 YEQRVPLLAVDRLSLAVQKGECFGLLGFNGAGKTTTFKMLTGEESLTSGDAFVGGHRISS 1449
Y R + + LSL V+KG+ L+G +G GK+T ++L +G + G
Sbjct: 1043 YPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKK 1102
Query: 1450 -DVGKVRQRIGYCPQFDALLDHMTGREMLVMYARLRGIPERHIGACVENTLRGLLLEPHA 1508
+V +R ++G Q L D E + R + + I + + + P
Sbjct: 1103 LNVQWLRAQLGIVSQEPILFDCSIA-ENIAYGDNSRVVSQDEIVSAA----KAANIHPFI 1157
Query: 1509 NKLVRTY-----------SGGNKRKLSTGIALIGEPAVIFLDEPSTGMDPVARRLLWDTV 1557
L Y SGG K++++ ALI +P ++ LDE ++ +D + +++ + +
Sbjct: 1158 ETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEAL 1217
Query: 1558 ARARESGKAIIITSHSMEECEALCTRLAIMVQGQFKCLGSPQHLKSKFGSGYSL 1611
+ARE G+ I+ +H + + + + G+ K G+ Q L ++ G +S+
Sbjct: 1218 DKARE-GRTCIVIAHRLSTIQN-ADLIVVFQNGRVKEHGTHQQLLAQKGIYFSM 1269
Score = 57.0 bits (136), Expect = 2e-07
Identities = 64/263 (24%), Positives = 110/263 (41%), Gaps = 13/263 (4%)
Query: 1373 PDSLLHTPLIIKELSKVYEQRVPLLAVDRLSLAVQKGECFGLLGFNGAGKTTTFKMLTGE 1432
PDS+ L ++ Y R + + L+L VQ G+ L+G +G GK+TT +++
Sbjct: 387 PDSIKGN-LEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRL 445
Query: 1433 ESLTSGDAFVGGHRISS-DVGKVRQRIGYCPQFDALLDHMTGREMLVMYARLRGIPERHI 1491
G + G I + +V +R+ IG Q L + Y R +
Sbjct: 446 YDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAEN--ICYGRGNVTMDEIK 503
Query: 1492 GACVE-NTLRGLLLEPH-----ANKLVRTYSGGNKRKLSTGIALIGEPAVIFLDEPSTGM 1545
A E N ++ P + SGG K++++ AL+ P ++ LDE ++ +
Sbjct: 504 KAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSAL 563
Query: 1546 DPVARRLLWDTVARARESGKAIIITSHSMEECEALCTRLAIMVQGQFKCLGSPQHLKSKF 1605
D + + + +ARE G+ I+ +H + +A G GS L K
Sbjct: 564 DTESEAEVQAALDKARE-GRTTIVIAHRLSTVRN-ADVIAGFEDGVIVEQGSHSELMKKE 621
Query: 1606 GSGYSLRAKVQSEGQQEALEEFK 1628
G + L +Q+ G Q EEF+
Sbjct: 622 GVYFKL-VNMQTSGSQIQSEEFE 643
>gi|156105685 ATP-binding cassette, sub-family B, member 8 [Homo
sapiens]
Length = 718
Score = 84.3 bits (207), Expect = 9e-16
Identities = 67/216 (31%), Positives = 110/216 (50%), Gaps = 13/216 (6%)
Query: 549 VRDLNLNLYEGQITVLLGHNGAGKTTTLSMLTGLFPPTSGRAYISGYEI-SQDMVQIR-K 606
++D L L G+I L+G +G GKTT S+L + PT+G + G ++ + D +R +
Sbjct: 473 LKDFTLTLPPGKIVALVGQSGGGKTTVASLLERFYDPTAGVVMLDGRDLRTLDPSWLRGQ 532
Query: 607 SLGLCPQHDILFDNLTVAEHLYFYAQLKGLSRQ--KCPEEVKQMLHIIGLEDKWNS---- 660
+G Q +LF T+ E++ F +L+ + E I + +N+
Sbjct: 533 VVGFISQEPVLFGT-TIMENIRF-GKLEASDEEVYTAAREANAHEFITSFPEGYNTVVGE 590
Query: 661 RSRFLSGGMRRKLSIGIALIAGSKVLILDEPTSGMDAISRRAIWDLLQRQKSDRTIVLTT 720
R LSGG +++L+I ALI VLILDE TS +DA S R + + L R + RT+++
Sbjct: 591 RGTTLSGGQKQRLAIARALIKQPTVLILDEATSALDAESERVVQEALDRASAGRTVLVIA 650
Query: 721 HFMDEADLLGDR-IAIMAKGELQCCGSSLFLKQKYG 755
H + + + G I +MA G + G+ L +K G
Sbjct: 651 HRL--STVRGAHCIVVMADGRVWEAGTHEELLKKGG 684
Score = 55.8 bits (133), Expect = 3e-07
Identities = 53/213 (24%), Positives = 95/213 (44%), Gaps = 14/213 (6%)
Query: 1403 SLAVQKGECFGLLGFNGAGKTTTFKMLTGEESLTSGDAFVGGHRISS-DVGKVR-QRIGY 1460
+L + G+ L+G +G GKTT +L T+G + G + + D +R Q +G+
Sbjct: 477 TLTLPPGKIVALVGQSGGGKTTVASLLERFYDPTAGVVMLDGRDLRTLDPSWLRGQVVGF 536
Query: 1461 CPQFDALLDHMTGREMLVMYARLRGIPERHIGACVENTLRGLLLE-PHANKLV-----RT 1514
Q L + + +L E A E + P V T
Sbjct: 537 ISQEPVLFGTTIMEN--IRFGKLEASDEEVYTAAREANAHEFITSFPEGYNTVVGERGTT 594
Query: 1515 YSGGNKRKLSTGIALIGEPAVIFLDEPSTGMDPVARRLLWDTVARARESGKAIIITSHSM 1574
SGG K++L+ ALI +P V+ LDE ++ +D + R++ + + RA +G+ +++ +H +
Sbjct: 595 LSGGQKQRLAIARALIKQPTVLILDEATSALDAESERVVQEALDRA-SAGRTVLVIAHRL 653
Query: 1575 EECE-ALCTRLAIMVQGQFKCLGSPQHLKSKFG 1606
A C + +M G+ G+ + L K G
Sbjct: 654 STVRGAHC--IVVMADGRVWEAGTHEELLKKGG 684
>gi|62526033 ATP-binding cassette, sub-family G, member 2 [Homo
sapiens]
Length = 655
Score = 82.8 bits (203), Expect = 3e-15
Identities = 69/225 (30%), Positives = 113/225 (50%), Gaps = 20/225 (8%)
Query: 561 ITVLLGHNGAGKTTTLSMLTGLFPPT--SGRAYISGYEISQDMVQIRKSLGLCPQHDILF 618
+ +LG G GK++ L +L P+ SG I+G + + + G Q D++
Sbjct: 75 LNAILGPTGGGKSSLLDVLAARKDPSGLSGDVLING---APRPANFKCNSGYVVQDDVVM 131
Query: 619 DNLTVAEHLYFYAQLK---GLSRQKCPEEVKQMLHIIGLEDKWNSRS-----RFLSGGMR 670
LTV E+L F A L+ ++ + E + +++ +GL+ +S+ R +SGG R
Sbjct: 132 GTLTVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKVADSKVGTQFIRGVSGGER 191
Query: 671 RKLSIGIALIAGSKVLILDEPTSGMDAISRRAIWDLLQR-QKSDRTIVLTTHFMDEADL- 728
++ SIG+ LI +L LDEPT+G+D+ + A+ LL+R K RTI+ + H +
Sbjct: 192 KRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIFSIHQPRYSIFK 251
Query: 729 LGDRIAIMAKGELQCCG-SSLFLKQKYGAGYHMTLVKEPHCNPED 772
L D + ++A G L G + L AGYH E + NP D
Sbjct: 252 LFDSLTLLASGRLMFHGPAQEALGYFESAGYHC----EAYNNPAD 292
Score = 66.2 bits (160), Expect = 3e-10
Identities = 57/212 (26%), Positives = 94/212 (44%), Gaps = 15/212 (7%)
Query: 1414 LLGFNGAGKTTTFKMLTGEE--SLTSGDAFVGGHRISSDVGKVRQRIGYCPQFDALLDHM 1471
+LG G GK++ +L + S SGD + G + + GY Q D ++ +
Sbjct: 78 ILGPTGGGKSSLLDVLAARKDPSGLSGDVLING---APRPANFKCNSGYVVQDDVVMGTL 134
Query: 1472 TGREMLVMYARLR---GIPERHIGACVENTLRGLLLEPHAN-----KLVRTYSGGNKRKL 1523
T RE L A LR + + ++ L L+ A+ + +R SGG +++
Sbjct: 135 TVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKVADSKVGTQFIRGVSGGERKRT 194
Query: 1524 STGIALIGEPAVIFLDEPSTGMDPVARRLLWDTVARARESGKAIIITSHSME-ECEALCT 1582
S G+ LI +P+++FLDEP+TG+D + + R + G+ II + H L
Sbjct: 195 SIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIFSIHQPRYSIFKLFD 254
Query: 1583 RLAIMVQGQFKCLGSPQHLKSKFGS-GYSLRA 1613
L ++ G+ G Q F S GY A
Sbjct: 255 SLTLLASGRLMFHGPAQEALGYFESAGYHCEA 286
>gi|46592978 ATP-binding cassette sub-family G member 1 isoform 7
[Homo sapiens]
Length = 663
Score = 82.4 bits (202), Expect = 3e-15
Identities = 60/187 (32%), Positives = 104/187 (55%), Gaps = 8/187 (4%)
Query: 559 GQITVLLGHNGAGKTTTLSMLTGLFPP-TSGRAYISGYEISQDMVQIRKSLGLCPQHDIL 617
G++ ++G +GAGK+T +++L G G I+G + +D+ RK Q D+L
Sbjct: 108 GELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLING--LPRDLRCFRKVSCYIMQDDML 165
Query: 618 FDNLTVAEHLYFYAQLKGLSRQKCPEE-VKQMLHIIGLEDKWNSRSRFLSGGMRRKLSIG 676
+LTV E + A LK + + E VK++L +GL N+R+ LSGG R++L+I
Sbjct: 166 LPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANTRTGSLSGGQRKRLAIA 225
Query: 677 IALIAGSKVLILDEPTSGMDAISRRAIWDLLQ-RQKSDRTIVLTTHFMDEADL--LGDRI 733
+ L+ V+ DEPTSG+D+ S + L++ + R+I+ T H A L L D++
Sbjct: 226 LELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIH-QPSAKLFELFDQL 284
Query: 734 AIMAKGE 740
++++G+
Sbjct: 285 YVLSQGQ 291
Score = 75.5 bits (184), Expect = 4e-13
Identities = 56/187 (29%), Positives = 96/187 (51%), Gaps = 7/187 (3%)
Query: 1409 GECFGLLGFNGAGKTTTFKMLTG-EESLTSGDAFVGGHRISSDVGKVRQRIGYCPQFDAL 1467
GE ++G +GAGK+T +L G E+ G + G + D+ R+ Y Q D L
Sbjct: 108 GELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLING--LPRDLRCFRKVSCYIMQDDML 165
Query: 1468 LDHMTGREMLVMYARLRGIPERHIGA--CVENTLRGLLLEPHANKLVRTYSGGNKRKLST 1525
L H+T +E +++ A L+ + E+ G V+ L L L AN + SGG +++L+
Sbjct: 166 LPHLTVQEAMMVSAHLK-LQEKDEGRREMVKEILTALGLLSCANTRTGSLSGGQRKRLAI 224
Query: 1526 GIALIGEPAVIFLDEPSTGMDPVARRLLWDTVARARESGKAIIITSHS-MEECEALCTRL 1584
+ L+ P V+F DEP++G+D + + + + G++II T H + L +L
Sbjct: 225 ALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIHQPSAKLFELFDQL 284
Query: 1585 AIMVQGQ 1591
++ QGQ
Sbjct: 285 YVLSQGQ 291
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.324 0.138 0.418
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 63,100,670
Number of Sequences: 37866
Number of extensions: 2786474
Number of successful extensions: 9169
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 77
Number of HSP's successfully gapped in prelim test: 10
Number of HSP's that attempted gapping in prelim test: 8454
Number of HSP's gapped (non-prelim): 378
length of query: 1704
length of database: 18,247,518
effective HSP length: 116
effective length of query: 1588
effective length of database: 13,855,062
effective search space: 22001838456
effective search space used: 22001838456
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.