Search of human proteins with 239744375

Search of human proteins with 239744375

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|239744375 PREDICTED: membrane-spanning 4-domains, subfamily
A, member 4E isoform 3 [Homo sapiens]
         (243 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|239744375 PREDICTED: membrane-spanning 4-domains, subfamily A...   484   e-137
gi|239755562 PREDICTED: membrane-spanning 4-domains, subfamily A...   483   e-137
gi|239750062 PREDICTED: membrane-spanning 4-domains, subfamily A...   483   e-137
gi|23110995 membrane-spanning 4-domains, subfamily A, member 4 i...   337   4e-93
gi|20070328 membrane-spanning 4-domains, subfamily A, member 4 i...   328   2e-90
gi|73486649 membrane-spanning 4-domains, subfamily A, member 3 i...    89   3e-18
gi|13899295 membrane-spanning 4-domains, subfamily A, member 8B ...    86   4e-17
gi|8923206 membrane-spanning 4-domains, subfamily A, member 12 [...    84   9e-17
gi|23110997 membrane-spanning 4-domains, subfamily A, member 5 [...    82   3e-16
gi|149588599 membrane-spanning 4-domains, subfamily A, member 15...    72   3e-13
gi|23238234 membrane-spanning 4-domains, subfamily A, member 6A ...    72   3e-13
gi|23238238 membrane-spanning 4-domains, subfamily A, member 6A ...    72   3e-13
gi|23110987 membrane-spanning 4-domains, subfamily A, member 1 [...    64   2e-10
gi|23110989 membrane-spanning 4-domains, subfamily A, member 1 [...    64   2e-10
gi|4503677 membrane-spanning 4-domains, subfamily A, member 2 is...    63   3e-10
gi|119226217 membrane-spanning 4-domains, subfamily A, member 14...    62   5e-10
gi|11139299 membrane-spanning 4-domains, subfamily A, member 7 i...    60   2e-09
gi|46249357 membrane-spanning 4-domains, subfamily A, member 7 i...    60   2e-09
gi|214831008 membrane-spanning 4-domains, subfamily A, member 2 ...    58   7e-09
gi|169202868 PREDICTED: similar to membrane-spanning 4-domains, ...    58   7e-09
gi|169203526 PREDICTED: similar to membrane-spanning 4-domains, ...    58   7e-09
gi|169202217 PREDICTED: similar to membrane-spanning 4-domains, ...    58   7e-09
gi|73486653 membrane-spanning 4-domains, subfamily A, member 3 i...    58   7e-09
gi|23238236 membrane-spanning 4-domains, subfamily A, member 6A ...    55   4e-08
gi|22749421 membrane-spanning 4-domains, subfamily A, member 15 ...    54   2e-07
gi|119226220 membrane-spanning 4-domains, subfamily A, member 14...    48   7e-06
gi|46249347 membrane-spanning 4-domains, subfamily A, member 7 i...    42   4e-04
gi|46249359 membrane-spanning 4-domains, subfamily A, member 7 i...    42   4e-04
gi|73486651 membrane-spanning 4-domains, subfamily A, member 3 i...    41   0.001
gi|155029533 membrane-spanning 4-domains, subfamily A, member 13...    35   0.045

>gi|239744375 PREDICTED: membrane-spanning 4-domains, subfamily A,
           member 4E isoform 3 [Homo sapiens]
          Length = 243

 Score =  484 bits (1246), Expect = e-137
 Identities = 243/243 (100%), Positives = 243/243 (100%)

Query: 1   MGAVGEWCLREDRNYAKLTFSAAMTTMQGMEQTTPGAGPDVPQLGNIDVIHSYLCKGLQE 60
           MGAVGEWCLREDRNYAKLTFSAAMTTMQGMEQTTPGAGPDVPQLGNIDVIHSYLCKGLQE
Sbjct: 1   MGAVGEWCLREDRNYAKLTFSAAMTTMQGMEQTTPGAGPDVPQLGNIDVIHSYLCKGLQE 60

Query: 61  KFFKRKPKVLGVVRILIALMSLSMGIIMMCVAFSSYEEHPIFVYVAYTIWGSVMFIISVS 120
           KFFKRKPKVLGVVRILIALMSLSMGIIMMCVAFSSYEEHPIFVYVAYTIWGSVMFIISVS
Sbjct: 61  KFFKRKPKVLGVVRILIALMSLSMGIIMMCVAFSSYEEHPIFVYVAYTIWGSVMFIISVS 120

Query: 121 LSVAAGIRTTKGLVGGSLGKNITSSVLAISGILINAISLTFYSFRYHYCNHDQLSSNCYM 180
           LSVAAGIRTTKGLVGGSLGKNITSSVLAISGILINAISLTFYSFRYHYCNHDQLSSNCYM
Sbjct: 121 LSVAAGIRTTKGLVGGSLGKNITSSVLAISGILINAISLTFYSFRYHYCNHDQLSSNCYM 180

Query: 181 TMSILMGTDGMVLLLSVLEFCIAVALSAFGCKVLCCSPSEVVLITPSNSHMAEIASPTPL 240
           TMSILMGTDGMVLLLSVLEFCIAVALSAFGCKVLCCSPSEVVLITPSNSHMAEIASPTPL
Sbjct: 181 TMSILMGTDGMVLLLSVLEFCIAVALSAFGCKVLCCSPSEVVLITPSNSHMAEIASPTPL 240

Query: 241 KTV 243
           KTV
Sbjct: 241 KTV 243


>gi|239755562 PREDICTED: membrane-spanning 4-domains, subfamily A,
           member 4E isoform 1 [Homo sapiens]
          Length = 243

 Score =  483 bits (1243), Expect = e-137
 Identities = 242/243 (99%), Positives = 243/243 (100%)

Query: 1   MGAVGEWCLREDRNYAKLTFSAAMTTMQGMEQTTPGAGPDVPQLGNIDVIHSYLCKGLQE 60
           MGAVGEWCLREDRNYAKLTFSAAMTTMQGMEQTTPGAGPDVPQLGNIDVIHSYLCKGLQE
Sbjct: 1   MGAVGEWCLREDRNYAKLTFSAAMTTMQGMEQTTPGAGPDVPQLGNIDVIHSYLCKGLQE 60

Query: 61  KFFKRKPKVLGVVRILIALMSLSMGIIMMCVAFSSYEEHPIFVYVAYTIWGSVMFIISVS 120
           KFFKRKPKVLGVVRILIALMSLSMGIIMMCVAFSSYEEHPIFVYVAYTIWGSVMFIISVS
Sbjct: 61  KFFKRKPKVLGVVRILIALMSLSMGIIMMCVAFSSYEEHPIFVYVAYTIWGSVMFIISVS 120

Query: 121 LSVAAGIRTTKGLVGGSLGKNITSSVLAISGILINAISLTFYSFRYHYCNHDQLSSNCYM 180
           LSVAAGIRTTKGLVGGSLGKNITSSVLAISGILINAISLTFYSFRYHYCNHDQLSSNCYM
Sbjct: 121 LSVAAGIRTTKGLVGGSLGKNITSSVLAISGILINAISLTFYSFRYHYCNHDQLSSNCYM 180

Query: 181 TMSILMGTDGMVLLLSVLEFCIAVALSAFGCKVLCCSPSEVVLITPSNSHMAEIASPTPL 240
           TMSILMGTDGMVLLLSVLEFCIAV+LSAFGCKVLCCSPSEVVLITPSNSHMAEIASPTPL
Sbjct: 181 TMSILMGTDGMVLLLSVLEFCIAVSLSAFGCKVLCCSPSEVVLITPSNSHMAEIASPTPL 240

Query: 241 KTV 243
           KTV
Sbjct: 241 KTV 243


>gi|239750062 PREDICTED: membrane-spanning 4-domains, subfamily A,
           member 4E isoform 3 [Homo sapiens]
          Length = 243

 Score =  483 bits (1243), Expect = e-137
 Identities = 242/243 (99%), Positives = 243/243 (100%)

Query: 1   MGAVGEWCLREDRNYAKLTFSAAMTTMQGMEQTTPGAGPDVPQLGNIDVIHSYLCKGLQE 60
           MGAVGEWCLREDRNYAKLTFSAAMTTMQGMEQTTPGAGPDVPQLGNIDVIHSYLCKGLQE
Sbjct: 1   MGAVGEWCLREDRNYAKLTFSAAMTTMQGMEQTTPGAGPDVPQLGNIDVIHSYLCKGLQE 60

Query: 61  KFFKRKPKVLGVVRILIALMSLSMGIIMMCVAFSSYEEHPIFVYVAYTIWGSVMFIISVS 120
           KFFKRKPKVLGVVRILIALMSLSMGIIMMCVAFSSYEEHPIFVYVAYTIWGSVMFIISVS
Sbjct: 61  KFFKRKPKVLGVVRILIALMSLSMGIIMMCVAFSSYEEHPIFVYVAYTIWGSVMFIISVS 120

Query: 121 LSVAAGIRTTKGLVGGSLGKNITSSVLAISGILINAISLTFYSFRYHYCNHDQLSSNCYM 180
           LSVAAGIRTTKGLVGGSLGKNITSSVLAISGILINAISLTFYSFRYHYCNHDQLSSNCYM
Sbjct: 121 LSVAAGIRTTKGLVGGSLGKNITSSVLAISGILINAISLTFYSFRYHYCNHDQLSSNCYM 180

Query: 181 TMSILMGTDGMVLLLSVLEFCIAVALSAFGCKVLCCSPSEVVLITPSNSHMAEIASPTPL 240
           TMSILMGTDGMVLLLSVLEFCIAV+LSAFGCKVLCCSPSEVVLITPSNSHMAEIASPTPL
Sbjct: 181 TMSILMGTDGMVLLLSVLEFCIAVSLSAFGCKVLCCSPSEVVLITPSNSHMAEIASPTPL 240

Query: 241 KTV 243
           KTV
Sbjct: 241 KTV 243


>gi|23110995 membrane-spanning 4-domains, subfamily A, member 4
           isoform b [Homo sapiens]
          Length = 239

 Score =  337 bits (865), Expect = 4e-93
 Identities = 174/225 (77%), Positives = 191/225 (84%)

Query: 19  TFSAAMTTMQGMEQTTPGAGPDVPQLGNIDVIHSYLCKGLQEKFFKRKPKVLGVVRILIA 78
           TFSAAMTTMQGMEQ  PGAGP VPQLGN+ VIHS+L KGLQEKF K +PKVLGVV+IL A
Sbjct: 15  TFSAAMTTMQGMEQAMPGAGPGVPQLGNMAVIHSHLWKGLQEKFLKGEPKVLGVVQILTA 74

Query: 79  LMSLSMGIIMMCVAFSSYEEHPIFVYVAYTIWGSVMFIISVSLSVAAGIRTTKGLVGGSL 138
           LMSLSMGI MMC+A ++Y  +PI VY+ YTIWGSVMFIIS SLS+AAGIRTTKGLV GSL
Sbjct: 75  LMSLSMGITMMCMASNTYGSNPISVYIGYTIWGSVMFIISGSLSIAAGIRTTKGLVRGSL 134

Query: 139 GKNITSSVLAISGILINAISLTFYSFRYHYCNHDQLSSNCYMTMSILMGTDGMVLLLSVL 198
           G NITSSVLA SGILIN  SL FYSF + YCN+   S+NC+ TMSILMG DGMVLLLSVL
Sbjct: 135 GMNITSSVLAASGILINTFSLAFYSFHHPYCNYYGNSNNCHGTMSILMGLDGMVLLLSVL 194

Query: 199 EFCIAVALSAFGCKVLCCSPSEVVLITPSNSHMAEIASPTPLKTV 243
           EFCIAV+LSAFGCKVLCC+P  VVLI PS+SHMAE ASPTPL  V
Sbjct: 195 EFCIAVSLSAFGCKVLCCTPGGVVLILPSHSHMAETASPTPLNEV 239


>gi|20070328 membrane-spanning 4-domains, subfamily A, member 4
           isoform a [Homo sapiens]
          Length = 220

 Score =  328 bits (842), Expect = 2e-90
 Identities = 169/220 (76%), Positives = 186/220 (84%)

Query: 24  MTTMQGMEQTTPGAGPDVPQLGNIDVIHSYLCKGLQEKFFKRKPKVLGVVRILIALMSLS 83
           MTTMQGMEQ  PGAGP VPQLGN+ VIHS+L KGLQEKF K +PKVLGVV+IL ALMSLS
Sbjct: 1   MTTMQGMEQAMPGAGPGVPQLGNMAVIHSHLWKGLQEKFLKGEPKVLGVVQILTALMSLS 60

Query: 84  MGIIMMCVAFSSYEEHPIFVYVAYTIWGSVMFIISVSLSVAAGIRTTKGLVGGSLGKNIT 143
           MGI MMC+A ++Y  +PI VY+ YTIWGSVMFIIS SLS+AAGIRTTKGLV GSLG NIT
Sbjct: 61  MGITMMCMASNTYGSNPISVYIGYTIWGSVMFIISGSLSIAAGIRTTKGLVRGSLGMNIT 120

Query: 144 SSVLAISGILINAISLTFYSFRYHYCNHDQLSSNCYMTMSILMGTDGMVLLLSVLEFCIA 203
           SSVLA SGILIN  SL FYSF + YCN+   S+NC+ TMSILMG DGMVLLLSVLEFCIA
Sbjct: 121 SSVLAASGILINTFSLAFYSFHHPYCNYYGNSNNCHGTMSILMGLDGMVLLLSVLEFCIA 180

Query: 204 VALSAFGCKVLCCSPSEVVLITPSNSHMAEIASPTPLKTV 243
           V+LSAFGCKVLCC+P  VVLI PS+SHMAE ASPTPL  V
Sbjct: 181 VSLSAFGCKVLCCTPGGVVLILPSHSHMAETASPTPLNEV 220


>gi|73486649 membrane-spanning 4-domains, subfamily A, member 3
           isoform a [Homo sapiens]
          Length = 214

 Score = 89.0 bits (219), Expect = 3e-18
 Identities = 52/169 (30%), Positives = 90/169 (53%), Gaps = 4/169 (2%)

Query: 64  KRKPKVLGVVRILIALMSLSMGIIMMCVAFS-SYEEHPIFV--YVAYTIWGSVMFIISVS 120
           K K +VLG ++IL A M L++G+ +  + +   +++H  F   Y  Y IWG+V F  S +
Sbjct: 45  KAKLQVLGAIQILNAAMILALGVFLGSLQYPYHFQKHFFFFTFYTGYPIWGAVFFCSSGT 104

Query: 121 LSVAAGIRTTKGLVGGSLGKNITSSVLAISGILINAISLTFYSFRYHYCNHDQLSSN-CY 179
           LSV AGI+ T+  +  S G NI S+ +A+ G    ++++         C+    S + C 
Sbjct: 105 LSVVAGIKPTRTWIQNSFGMNIASATIALVGTAFLSLNIAVNIQSLRSCHSSSESPDLCN 164

Query: 180 MTMSILMGTDGMVLLLSVLEFCIAVALSAFGCKVLCCSPSEVVLITPSN 228
              SI  G   ++L+L++LE C+ ++  A  C   CC+  E +   P++
Sbjct: 165 YMGSISNGMVSLLLILTLLELCVTISTIAMWCNANCCNSREEISSPPNS 213


>gi|13899295 membrane-spanning 4-domains, subfamily A, member 8B
           [Homo sapiens]
          Length = 250

 Score = 85.5 bits (210), Expect = 4e-17
 Identities = 59/177 (33%), Positives = 94/177 (53%), Gaps = 8/177 (4%)

Query: 65  RKPKVLGVVRILIALMSLSMGIIMMCVAFSSYEEHPIFVYVAYTIWGSVMFIISVSLSVA 124
           ++ K LG ++I+I L  + +G IM  V    Y    I  Y  +  WG + FIIS SLSVA
Sbjct: 67  KEGKTLGAIQIIIGLAHIGLGSIMATVLVGEYLS--ISFYGGFPFWGGLWFIISGSLSVA 124

Query: 125 AGIRT-TKGLVGGSLGKNITSSVLAISGILINAISLTFYSFRYHYCNHDQLSSNCYMTMS 183
           A  +  +  L+ GSLG NI S++ +  G+++    L+     Y Y ++   +      M+
Sbjct: 125 AENQPYSYCLLSGSLGLNIVSAICSAVGVILFITDLSI-PHPYAYPDYYPYAWGVNPGMA 183

Query: 184 ILMGTDGMVLLLSVLEFCIAVALSAFGCKVLCCSPSEVVLITPSNSHMAEIASPTPL 240
           I     G++L+  +LEF IA A S FGC+++CC  S V +I P+      + +P P+
Sbjct: 184 I----SGVLLVFCLLEFGIACASSHFGCQLVCCQSSNVSVIYPNIYAANPVITPEPV 236


>gi|8923206 membrane-spanning 4-domains, subfamily A, member 12
           [Homo sapiens]
          Length = 267

 Score = 84.3 bits (207), Expect = 9e-17
 Identities = 60/196 (30%), Positives = 98/196 (50%), Gaps = 16/196 (8%)

Query: 33  TTPGA-GPDVPQLGNIDVIHSYLCKGLQEKFFKRKPKVLGVVRILIALMSLSMGIIMMCV 91
           T+PG      P  GNI +I+  +  G     FK + K LGV++I++ LM +  GI++  +
Sbjct: 55  TSPGIFASSQPGQGNIQMINPSV--GTAVMNFKEEAKALGVIQIMVGLMHIGFGIVLCLI 112

Query: 92  AFSSYEE---HPIFVYVAYTIWGSVMFIISVSLSVAAGIRTTKGLVGGSLGKNITSSVLA 148
           +FS  E        V   Y  WG + FIIS SLSV+A    ++ LV GSLG NI SS+LA
Sbjct: 113 SFSFREVLGFASTAVIGGYPFWGGLSFIISGSLSVSASKELSRCLVKGSLGMNIVSSILA 172

Query: 149 ISGILINAISLTFYSFRYHYCNHDQLSSNCYMTMSILMGTDGMVLLLSVLEFCIAVALSA 208
             G+++  + +            + ++   Y  +    G    +++ S+LEF +A A + 
Sbjct: 173 FIGVILLLVDMCI----------NGVAGQDYWAVLSGKGISATLMIFSLLEFFVACATAH 222

Query: 209 FGCKVLCCSPSEVVLI 224
           F  +    +   V++I
Sbjct: 223 FANQANTTTNMSVLVI 238


>gi|23110997 membrane-spanning 4-domains, subfamily A, member 5
           [Homo sapiens]
          Length = 200

 Score = 82.4 bits (202), Expect = 3e-16
 Identities = 45/152 (29%), Positives = 78/152 (51%), Gaps = 2/152 (1%)

Query: 60  EKFFKRKPKVLGVVRILIALMSLSMGIIMMCVAFSSYEEHPIFVYVAYTIWGSVMFIISV 119
           +K F RK K+LG ++IL  +M+ S G+I +      Y   P      Y  WGSV+FI S 
Sbjct: 40  QKLFARKMKILGTIQILFGIMTFSFGVIFLFTLLKPYPRFPFIFLSGYPFWGSVLFINSG 99

Query: 120 SLSVAAGIRTTKGLVGGSLGKNITSSVLAISGILINAISLTFYSFRYHYCNHDQLSSNCY 179
           +  +A   +TT+ L+  S   N  S++ AI+GI++  ++  F   + + C +   +S C 
Sbjct: 100 AFLIAVKRKTTETLIILSRIMNFLSALGAIAGIIL--LTFGFILDQNYICGYSHQNSQCK 157

Query: 180 MTMSILMGTDGMVLLLSVLEFCIAVALSAFGC 211
               + +G    ++  S++E  I++  S  GC
Sbjct: 158 AVTVLFLGILITLMTFSIIELFISLPFSILGC 189


>gi|149588599 membrane-spanning 4-domains, subfamily A, member 15
           isoform 1 [Homo sapiens]
          Length = 240

 Score = 72.4 bits (176), Expect = 3e-13
 Identities = 59/180 (32%), Positives = 81/180 (45%), Gaps = 21/180 (11%)

Query: 60  EKFFKRKPKVLGVVRILIALMSLSMGIIMMCVAFSSYEEHPIFVYVAYTIWGSVMFIISV 119
           E F   +PKVLG V+ILI L+ L  G +++ V          F+      WG   FIIS 
Sbjct: 64  ETFLTGEPKVLGTVQILIGLIHLGFGSVLLMVRRGHVGI--FFIEGGVPFWGGACFIISG 121

Query: 120 SLSVAAGIRTTKGLVGGSLGKNITSSVLAISGILINAISLTFYSFRYHYCNHDQLSSNCY 179
           SLSVAA    T  LV  SLG NI S + A +G  I  +        +   N D       
Sbjct: 122 SLSVAAEKNHTSCLVRSSLGTNILSVMAAFAGTAILLMD-------FGVTNRD------- 167

Query: 180 MTMSILMGTDGMVLLLSVLEFCIAVALSAFGCKVLCCSPSEVVLITPSNSHMAEIASPTP 239
               +  G   ++ + +VLEF  AV    FGC+ +    S  V+  P N+  A+   P+P
Sbjct: 168 ----VDRGYLAVLTIFTVLEFFTAVIAMHFGCQAIHAQASAPVIFLP-NAFSADFNIPSP 222


>gi|23238234 membrane-spanning 4-domains, subfamily A, member 6A
           isoform 2 [Homo sapiens]
          Length = 225

 Score = 72.4 bits (176), Expect = 3e-13
 Identities = 58/173 (33%), Positives = 87/173 (50%), Gaps = 37/173 (21%)

Query: 60  EKFFKRKPKVLGVVRILIALMSLSMGIIMMCVAFSSYEEHPIFVYV-------AYTIWGS 112
           +K    + KV+G ++IL  +M LS+GII+   +FS     P F  V       AY   G 
Sbjct: 38  KKHLHAEIKVIGTIQILCGMMVLSLGIILASASFS-----PNFTQVTSTLLNSAYPFIGP 92

Query: 113 VMFIISVSLSVAAGIRTTKGLVGGSLGKNITSSVLAISGILI------------------ 154
             FIIS SLS+A   R TK LV  SL  +I S++ A+ G +I                  
Sbjct: 93  FFFIISGSLSIATEKRLTKLLVHSSLVGSILSALSALVGFIILSVKQATLNPASLQCELD 152

Query: 155 --NAISLTFYSFRYHYCNHDQL-SSNCYMTMSILMGTDGMVLLLSVLEFCIAV 204
             N  + ++ S+ Y    HD L +++CY   + L GT  ++L+ ++LEFC+AV
Sbjct: 153 KNNIPTRSYVSYFY----HDSLYTTDCYTAKASLAGTLSLMLICTLLEFCLAV 201


>gi|23238238 membrane-spanning 4-domains, subfamily A, member 6A
           isoform 1 [Homo sapiens]
          Length = 248

 Score = 72.4 bits (176), Expect = 3e-13
 Identities = 58/173 (33%), Positives = 87/173 (50%), Gaps = 37/173 (21%)

Query: 60  EKFFKRKPKVLGVVRILIALMSLSMGIIMMCVAFSSYEEHPIFVYV-------AYTIWGS 112
           +K    + KV+G ++IL  +M LS+GII+   +FS     P F  V       AY   G 
Sbjct: 38  KKHLHAEIKVIGTIQILCGMMVLSLGIILASASFS-----PNFTQVTSTLLNSAYPFIGP 92

Query: 113 VMFIISVSLSVAAGIRTTKGLVGGSLGKNITSSVLAISGILI------------------ 154
             FIIS SLS+A   R TK LV  SL  +I S++ A+ G +I                  
Sbjct: 93  FFFIISGSLSIATEKRLTKLLVHSSLVGSILSALSALVGFIILSVKQATLNPASLQCELD 152

Query: 155 --NAISLTFYSFRYHYCNHDQL-SSNCYMTMSILMGTDGMVLLLSVLEFCIAV 204
             N  + ++ S+ Y    HD L +++CY   + L GT  ++L+ ++LEFC+AV
Sbjct: 153 KNNIPTRSYVSYFY----HDSLYTTDCYTAKASLAGTLSLMLICTLLEFCLAV 201


>gi|23110987 membrane-spanning 4-domains, subfamily A, member 1
           [Homo sapiens]
          Length = 297

 Score = 63.5 bits (153), Expect = 2e-10
 Identities = 54/196 (27%), Positives = 87/196 (44%), Gaps = 30/196 (15%)

Query: 57  GLQEKFFKRKPKVLGVVRILIALMSLSMGIIMMCVAFSSYEEHPIFVYVAYTIWGSVMFI 116
           G  + FF R+ K LG V+I+  L  +++G ++M  A   Y   PI V V Y +WG +M+I
Sbjct: 39  GPTQSFFMRESKTLGAVQIMNGLFHIALGGLLMIPA-GIYA--PICVTVWYPLWGGIMYI 95

Query: 117 ISVSLSVAAGIRTTKGLVGGSLGKNITSSVLAISGILINAI--------------SLTFY 162
           IS SL  A    + K LV G +  N  S   AISG++++ +              SL F 
Sbjct: 96  ISGSLLAATEKNSRKCLVKGKMIMNSLSLFAAISGMILSIMDILNIKISHFLKMESLNFI 155

Query: 163 SFRYHYCN------------HDQLSSNCYMTMSILMGTDGMVLLLSVLEFCIAVALSAFG 210
                Y N            +   +  CY   S+ +G   ++L+ +  +  +   +    
Sbjct: 156 RAHTPYINIYNCEPANPSEKNSPSTQYCYSIQSLFLGILSVMLIFAFFQELVIAGIVENE 215

Query: 211 CKVLCCSP-SEVVLIT 225
            K  C  P S +VL++
Sbjct: 216 WKRTCSRPKSNIVLLS 231


>gi|23110989 membrane-spanning 4-domains, subfamily A, member 1
           [Homo sapiens]
          Length = 297

 Score = 63.5 bits (153), Expect = 2e-10
 Identities = 54/196 (27%), Positives = 87/196 (44%), Gaps = 30/196 (15%)

Query: 57  GLQEKFFKRKPKVLGVVRILIALMSLSMGIIMMCVAFSSYEEHPIFVYVAYTIWGSVMFI 116
           G  + FF R+ K LG V+I+  L  +++G ++M  A   Y   PI V V Y +WG +M+I
Sbjct: 39  GPTQSFFMRESKTLGAVQIMNGLFHIALGGLLMIPA-GIYA--PICVTVWYPLWGGIMYI 95

Query: 117 ISVSLSVAAGIRTTKGLVGGSLGKNITSSVLAISGILINAI--------------SLTFY 162
           IS SL  A    + K LV G +  N  S   AISG++++ +              SL F 
Sbjct: 96  ISGSLLAATEKNSRKCLVKGKMIMNSLSLFAAISGMILSIMDILNIKISHFLKMESLNFI 155

Query: 163 SFRYHYCN------------HDQLSSNCYMTMSILMGTDGMVLLLSVLEFCIAVALSAFG 210
                Y N            +   +  CY   S+ +G   ++L+ +  +  +   +    
Sbjct: 156 RAHTPYINIYNCEPANPSEKNSPSTQYCYSIQSLFLGILSVMLIFAFFQELVIAGIVENE 215

Query: 211 CKVLCCSP-SEVVLIT 225
            K  C  P S +VL++
Sbjct: 216 WKRTCSRPKSNIVLLS 231


>gi|4503677 membrane-spanning 4-domains, subfamily A, member 2
           isoform 1 [Homo sapiens]
          Length = 244

 Score = 62.8 bits (151), Expect = 3e-10
 Identities = 50/151 (33%), Positives = 74/151 (49%), Gaps = 6/151 (3%)

Query: 64  KRKPKVLGVVRILIALMSLSMGIIMMCVAFSSYEEHPIF--VYVAYTIWGSVMFIISVSL 121
           K++ + LGV +IL A++ L  G ++  V   S+ E  IF      Y  WG++ F IS  L
Sbjct: 55  KKEQEFLGVTQILTAMICLCFGTVVCSVLDISHIEGDIFSSFKAGYPFWGAIFFSISGML 114

Query: 122 SVAAGIRTTKGLVGGSLGKNITSSVLAISGILINAISL--TFYSFRYHYCNHDQLSSNCY 179
           S+ +  R    LV GSLG N  SS+   +GI I  I+L  +      H C      + C+
Sbjct: 115 SIISERRNATYLVRGSLGANTASSIAGGTGITILIINLKKSLAYIHIHSC-QKFFETKCF 173

Query: 180 MTMSILMGTDGMVLLLSVLEFCIAVALSAFG 210
           M  S       M+L L++L    AV+L+  G
Sbjct: 174 MA-SFSTEIVVMMLFLTILGLGSAVSLTICG 203


>gi|119226217 membrane-spanning 4-domains, subfamily A, member 14
           isoform 1 [Homo sapiens]
          Length = 679

 Score = 62.0 bits (149), Expect = 5e-10
 Identities = 37/125 (29%), Positives = 63/125 (50%), Gaps = 5/125 (4%)

Query: 62  FFKRKPKVLGVVRILIALMSLSMGIIMMCVAFSSYEEHPIFVYVAYTIWGSVMFIISVSL 121
           F K +P+VLG  +IL+AL+ +  G I         +  P+ V   Y  WG+++FI++  L
Sbjct: 37  FLKGEPRVLGATQILLALIIVGFGTIFALNYIGFSQRLPLVVLTGYPFWGALIFILTGYL 96

Query: 122 SVAAGIRTTKGLVGGSLGKNITSSVLAISGILINAISLTFYSFRYHYCNHDQLSSNCYMT 181
           +V    + +K L  G  G N+ SS++AI+GI    +S   Y  +  YC        C  +
Sbjct: 97  TVTD--KKSKLLGQGVTGMNVISSLVAITGITFTILS---YRHQDKYCQMPSFEEICVFS 151

Query: 182 MSILM 186
            ++ +
Sbjct: 152 RTLFI 156


>gi|11139299 membrane-spanning 4-domains, subfamily A, member 7
           isoform 1 [Homo sapiens]
          Length = 240

 Score = 60.1 bits (144), Expect = 2e-09
 Identities = 56/203 (27%), Positives = 90/203 (44%), Gaps = 19/203 (9%)

Query: 51  HSYLCKGLQEKFFKRKPKVLGVVRILIALMSLSMGIIMMCVAFSSYEEHPIFVYV--AYT 108
           H Y  +   +     +  VLG V+IL  L+  S+G I++   + S+    I   +   Y 
Sbjct: 29  HMYQNEDYLQNGLPTETTVLGTVQILCCLLISSLGAILVFAPYPSHFNPAISTTLMSGYP 88

Query: 109 IWGSVMFIISVSLSVAAGIRTTKGLVGGSLGKNITSSVLAISGILINAISLTFYSFRYHY 168
             G++ F I+ SLS+ +G ++TK     SL  N  SSV A +G+ + A S+        +
Sbjct: 89  FLGALCFGITGSLSIISGKQSTKPFDLSSLTSNAVSSVTAGAGLFLLADSMVALRTASQH 148

Query: 169 CNH--DQLSS--------------NCYMTMSILMGTDGMVLLLSVLEFCIAVALSAFGCK 212
           C    D LSS              +C +T   L G   ++L+ +VLE  +A   S F  K
Sbjct: 149 CGSEMDYLSSLPYSEYYYPIYEIKDCLLTSVSLTGVLVVMLIFTVLELLLAAYSSVFWWK 208

Query: 213 VLCC-SPSEVVLITPSNSHMAEI 234
            L   +P      T S  H+ ++
Sbjct: 209 QLYSNNPGSSFSSTQSQDHIQQV 231


>gi|46249357 membrane-spanning 4-domains, subfamily A, member 7
           isoform 1 [Homo sapiens]
          Length = 240

 Score = 60.1 bits (144), Expect = 2e-09
 Identities = 56/203 (27%), Positives = 90/203 (44%), Gaps = 19/203 (9%)

Query: 51  HSYLCKGLQEKFFKRKPKVLGVVRILIALMSLSMGIIMMCVAFSSYEEHPIFVYV--AYT 108
           H Y  +   +     +  VLG V+IL  L+  S+G I++   + S+    I   +   Y 
Sbjct: 29  HMYQNEDYLQNGLPTETTVLGTVQILCCLLISSLGAILVFAPYPSHFNPAISTTLMSGYP 88

Query: 109 IWGSVMFIISVSLSVAAGIRTTKGLVGGSLGKNITSSVLAISGILINAISLTFYSFRYHY 168
             G++ F I+ SLS+ +G ++TK     SL  N  SSV A +G+ + A S+        +
Sbjct: 89  FLGALCFGITGSLSIISGKQSTKPFDLSSLTSNAVSSVTAGAGLFLLADSMVALRTASQH 148

Query: 169 CNH--DQLSS--------------NCYMTMSILMGTDGMVLLLSVLEFCIAVALSAFGCK 212
           C    D LSS              +C +T   L G   ++L+ +VLE  +A   S F  K
Sbjct: 149 CGSEMDYLSSLPYSEYYYPIYEIKDCLLTSVSLTGVLVVMLIFTVLELLLAAYSSVFWWK 208

Query: 213 VLCC-SPSEVVLITPSNSHMAEI 234
            L   +P      T S  H+ ++
Sbjct: 209 QLYSNNPGSSFSSTQSQDHIQQV 231


>gi|214831008 membrane-spanning 4-domains, subfamily A, member 2
           isoform 2 [Homo sapiens]
          Length = 195

 Score = 58.2 bits (139), Expect = 7e-09
 Identities = 37/98 (37%), Positives = 53/98 (54%), Gaps = 2/98 (2%)

Query: 64  KRKPKVLGVVRILIALMSLSMGIIMMCVAFSSYEEHPIF--VYVAYTIWGSVMFIISVSL 121
           K++ + LGV +IL A++ L  G ++  V   S+ E  IF      Y  WG++ F IS  L
Sbjct: 55  KKEQEFLGVTQILTAMICLCFGTVVCSVLDISHIEGDIFSSFKAGYPFWGAIFFSISGML 114

Query: 122 SVAAGIRTTKGLVGGSLGKNITSSVLAISGILINAISL 159
           S+ +  R    LV GSLG N  SS+   +GI I  I+L
Sbjct: 115 SIISERRNATYLVRGSLGANTASSIAGGTGITILIINL 152


>gi|169202868 PREDICTED: similar to membrane-spanning 4-domains,
           subfamily A, member 8B [Homo sapiens]
          Length = 391

 Score = 58.2 bits (139), Expect = 7e-09
 Identities = 37/121 (30%), Positives = 58/121 (47%), Gaps = 17/121 (14%)

Query: 107 YTIWGSVMFIISVSLSVAAGIRTTKGLVGGSLGKNITSSVLAISGILINAISLTFYSFRY 166
           Y +WG + +I+S SLSV A    +  +V  S+  NI S++ A +GI I    L+ Y    
Sbjct: 181 YPLWGGLSYIVSGSLSVWAAKDPSPCVVNSSISFNIISALFAFAGIFIIITDLSLY---- 236

Query: 167 HYCNHDQLSSNCYMTMSILMGTDGMVLLLSVLEFCIAVALSAFGCKVLCCSPSEVVLITP 226
                       Y+T +      G +L  ++LEF +   +S FGC+  CC   E V + P
Sbjct: 237 ------------YVT-TYSKAVSGGLLPFALLEFILTCVVSHFGCQATCCRQFENVAVIP 283

Query: 227 S 227
           +
Sbjct: 284 T 284


>gi|169203526 PREDICTED: similar to membrane-spanning 4-domains,
           subfamily A, member 8B [Homo sapiens]
          Length = 391

 Score = 58.2 bits (139), Expect = 7e-09
 Identities = 37/121 (30%), Positives = 58/121 (47%), Gaps = 17/121 (14%)

Query: 107 YTIWGSVMFIISVSLSVAAGIRTTKGLVGGSLGKNITSSVLAISGILINAISLTFYSFRY 166
           Y +WG + +I+S SLSV A    +  +V  S+  NI S++ A +GI I    L+ Y    
Sbjct: 181 YPLWGGLSYIVSGSLSVWAAKDPSPCVVNSSISFNIISALFAFAGIFIIITDLSLY---- 236

Query: 167 HYCNHDQLSSNCYMTMSILMGTDGMVLLLSVLEFCIAVALSAFGCKVLCCSPSEVVLITP 226
                       Y+T +      G +L  ++LEF +   +S FGC+  CC   E V + P
Sbjct: 237 ------------YVT-TYSKAVSGGLLPFALLEFILTCVVSHFGCQATCCRQFENVAVIP 283

Query: 227 S 227
           +
Sbjct: 284 T 284


>gi|169202217 PREDICTED: similar to membrane-spanning 4-domains,
           subfamily A, member 8B [Homo sapiens]
          Length = 391

 Score = 58.2 bits (139), Expect = 7e-09
 Identities = 37/121 (30%), Positives = 58/121 (47%), Gaps = 17/121 (14%)

Query: 107 YTIWGSVMFIISVSLSVAAGIRTTKGLVGGSLGKNITSSVLAISGILINAISLTFYSFRY 166
           Y +WG + +I+S SLSV A    +  +V  S+  NI S++ A +GI I    L+ Y    
Sbjct: 181 YPLWGGLSYIVSGSLSVWAAKDPSPCVVNSSISFNIISALFAFAGIFIIITDLSLY---- 236

Query: 167 HYCNHDQLSSNCYMTMSILMGTDGMVLLLSVLEFCIAVALSAFGCKVLCCSPSEVVLITP 226
                       Y+T +      G +L  ++LEF +   +S FGC+  CC   E V + P
Sbjct: 237 ------------YVT-TYSKAVSGGLLPFALLEFILTCVVSHFGCQATCCRQFENVAVIP 283

Query: 227 S 227
           +
Sbjct: 284 T 284


>gi|73486653 membrane-spanning 4-domains, subfamily A, member 3
           isoform b [Homo sapiens]
          Length = 168

 Score = 58.2 bits (139), Expect = 7e-09
 Identities = 33/115 (28%), Positives = 58/115 (50%), Gaps = 1/115 (0%)

Query: 115 FIISVSLSVAAGIRTTKGLVGGSLGKNITSSVLAISGILINAISLTFYSFRYHYCNHDQL 174
           F  S +LSV AGI+ T+  +  S G NI S+ +A+ G    ++++         C+    
Sbjct: 53  FCSSGTLSVVAGIKPTRTWIQNSFGMNIASATIALVGTAFLSLNIAVNIQSLRSCHSSSE 112

Query: 175 SSN-CYMTMSILMGTDGMVLLLSVLEFCIAVALSAFGCKVLCCSPSEVVLITPSN 228
           S + C    SI  G   ++L+L++LE C+ ++  A  C   CC+  E +   P++
Sbjct: 113 SPDLCNYMGSISNGMVSLLLILTLLELCVTISTIAMWCNANCCNSREEISSPPNS 167


>gi|23238236 membrane-spanning 4-domains, subfamily A, member 6A
           isoform 3 [Homo sapiens]
          Length = 178

 Score = 55.5 bits (132), Expect = 4e-08
 Identities = 40/105 (38%), Positives = 57/105 (54%), Gaps = 12/105 (11%)

Query: 60  EKFFKRKPKVLGVVRILIALMSLSMGIIMMCVAFSSYEEHPIFVYV-------AYTIWGS 112
           +K    + KV+G ++IL  +M LS+GII+   +FS     P F  V       AY   G 
Sbjct: 38  KKHLHAEIKVIGTIQILCGMMVLSLGIILASASFS-----PNFTQVTSTLLNSAYPFIGP 92

Query: 113 VMFIISVSLSVAAGIRTTKGLVGGSLGKNITSSVLAISGILINAI 157
             FIIS SLS+A   R TK LV  SL  +I S++ A+ G +I ++
Sbjct: 93  FFFIISGSLSIATEKRLTKLLVHSSLVGSILSALSALVGFIILSV 137


>gi|22749421 membrane-spanning 4-domains, subfamily A, member 15
           isoform 2 [Homo sapiens]
          Length = 147

 Score = 53.5 bits (127), Expect = 2e-07
 Identities = 44/138 (31%), Positives = 60/138 (43%), Gaps = 19/138 (13%)

Query: 102 FVYVAYTIWGSVMFIISVSLSVAAGIRTTKGLVGGSLGKNITSSVLAISGILINAISLTF 161
           F+      WG   FIIS SLSVAA    T  LV  SLG NI S + A +G  I  +    
Sbjct: 11  FIEGGVPFWGGACFIISGSLSVAAEKNHTSCLVRSSLGTNILSVMAAFAGTAILLMD--- 67

Query: 162 YSFRYHYCNHDQLSSNCYMTMSILMGTDGMVLLLSVLEFCIAVALSAFGCKVLCCSPSEV 221
               +   N D           +  G   ++ + +VLEF  AV    FGC+ +    S  
Sbjct: 68  ----FGVTNRD-----------VDRGYLAVLTIFTVLEFFTAVIAMHFGCQAIHAQASAP 112

Query: 222 VLITPSNSHMAEIASPTP 239
           V+  P N+  A+   P+P
Sbjct: 113 VIFLP-NAFSADFNIPSP 129


>gi|119226220 membrane-spanning 4-domains, subfamily A, member 14
           isoform 2 [Homo sapiens]
          Length = 662

 Score = 48.1 bits (113), Expect = 7e-06
 Identities = 33/126 (26%), Positives = 53/126 (42%), Gaps = 24/126 (19%)

Query: 62  FFKRKPKVLGVVRILIALMSLSMGIIMMCVAFSSYEEHPIFVYVAYTIWGSVMFIISVSL 121
           F K +P+VLG  +IL+AL+ +  G I         +  P+ V   Y  WG+         
Sbjct: 37  FLKGEPRVLGATQILLALIIVGFGTIFALNYIGFSQRLPLVVLTGYPFWGA--------- 87

Query: 122 SVAAGIRTTKGLVG-GSLGKNITSSVLAISGILINAISLTFYSFRYHYCNHDQLSSNCYM 180
                      L+G G  G N+ SS++AI+GI    +S   Y  +  YC        C  
Sbjct: 88  -----------LIGQGVTGMNVISSLVAITGITFTILS---YRHQDKYCQMPSFEEICVF 133

Query: 181 TMSILM 186
           + ++ +
Sbjct: 134 SRTLFI 139


>gi|46249347 membrane-spanning 4-domains, subfamily A, member 7
           isoform 2 [Homo sapiens]
          Length = 195

 Score = 42.4 bits (98), Expect = 4e-04
 Identities = 40/137 (29%), Positives = 61/137 (44%), Gaps = 17/137 (12%)

Query: 115 FIISVSLSVAAGIRTTKGLVGGSLGKNITSSVLAISGILINAISLTFYSFRYHYCNH--D 172
           F I+ SLS+ +G ++TK     SL  N  SSV A +G+ + A S+        +C    D
Sbjct: 50  FGITGSLSIISGKQSTKPFDLSSLTSNAVSSVTAGAGLFLLADSMVALRTASQHCGSEMD 109

Query: 173 QLSS--------------NCYMTMSILMGTDGMVLLLSVLEFCIAVALSAFGCKVLCC-S 217
            LSS              +C +T   L G   ++L+ +VLE  +A   S F  K L   +
Sbjct: 110 YLSSLPYSEYYYPIYEIKDCLLTSVSLTGVLVVMLIFTVLELLLAAYSSVFWWKQLYSNN 169

Query: 218 PSEVVLITPSNSHMAEI 234
           P      T S  H+ ++
Sbjct: 170 PGSSFSSTQSQDHIQQV 186


>gi|46249359 membrane-spanning 4-domains, subfamily A, member 7
           isoform 2 [Homo sapiens]
          Length = 195

 Score = 42.4 bits (98), Expect = 4e-04
 Identities = 40/137 (29%), Positives = 61/137 (44%), Gaps = 17/137 (12%)

Query: 115 FIISVSLSVAAGIRTTKGLVGGSLGKNITSSVLAISGILINAISLTFYSFRYHYCNH--D 172
           F I+ SLS+ +G ++TK     SL  N  SSV A +G+ + A S+        +C    D
Sbjct: 50  FGITGSLSIISGKQSTKPFDLSSLTSNAVSSVTAGAGLFLLADSMVALRTASQHCGSEMD 109

Query: 173 QLSS--------------NCYMTMSILMGTDGMVLLLSVLEFCIAVALSAFGCKVLCC-S 217
            LSS              +C +T   L G   ++L+ +VLE  +A   S F  K L   +
Sbjct: 110 YLSSLPYSEYYYPIYEIKDCLLTSVSLTGVLVVMLIFTVLELLLAAYSSVFWWKQLYSNN 169

Query: 218 PSEVVLITPSNSHMAEI 234
           P      T S  H+ ++
Sbjct: 170 PGSSFSSTQSQDHIQQV 186


>gi|73486651 membrane-spanning 4-domains, subfamily A, member 3
           isoform c [Homo sapiens]
          Length = 91

 Score = 40.8 bits (94), Expect = 0.001
 Identities = 22/89 (24%), Positives = 43/89 (48%), Gaps = 1/89 (1%)

Query: 141 NITSSVLAISGILINAISLTFYSFRYHYCNHDQLSSN-CYMTMSILMGTDGMVLLLSVLE 199
           NI S+ +A+ G    ++++         C+    S + C    SI  G   ++L+L++LE
Sbjct: 2   NIASATIALVGTAFLSLNIAVNIQSLRSCHSSSESPDLCNYMGSISNGMVSLLLILTLLE 61

Query: 200 FCIAVALSAFGCKVLCCSPSEVVLITPSN 228
            C+ ++  A  C   CC+  E +   P++
Sbjct: 62  LCVTISTIAMWCNANCCNSREEISSPPNS 90


>gi|155029533 membrane-spanning 4-domains, subfamily A, member 13
           isoform 1 [Homo sapiens]
          Length = 152

 Score = 35.4 bits (80), Expect = 0.045
 Identities = 34/157 (21%), Positives = 64/157 (40%), Gaps = 12/157 (7%)

Query: 69  VLGVVRILIALMSLSMGIIMMCVAFSSYEEHPIFVYVAYTIWGSVMFIISVSLSVAAGIR 128
           ++G+  I +    L + +  +  AF +YE  P+      T+WG    I  V L       
Sbjct: 1   MIGIFHIFMWYFLLVLYMGQIKGAFGTYE--PVTYKTGCTLWGIFFIIAGVFLIRVTKYP 58

Query: 129 TTKGLVGGSLGKNITSSVLAISGILINAISLTFYSFRYHYCNHDQLSSNCYMTMSILMGT 188
           T  G++  +L  NI   +  I+ + +  I L+ ++          +S   Y    +    
Sbjct: 59  TRSGIIS-TLIINIICIITTITAVTLTIIELSHFN---------SVSYRNYGQAKLGREV 108

Query: 189 DGMVLLLSVLEFCIAVALSAFGCKVLCCSPSEVVLIT 225
             ++L    LEF IA+  S + C  L    +++  +T
Sbjct: 109 SRILLFFYGLEFSIALTHSIYSCSNLFRRQNDLTSVT 145


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.325    0.136    0.409 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 8,370,950
Number of Sequences: 37866
Number of extensions: 317844
Number of successful extensions: 1098
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 32
Number of HSP's successfully gapped in prelim test: 4
Number of HSP's that attempted gapping in prelim test: 1043
Number of HSP's gapped (non-prelim): 36
length of query: 243
length of database: 18,247,518
effective HSP length: 99
effective length of query: 144
effective length of database: 14,498,784
effective search space: 2087824896
effective search space used: 2087824896
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 60 (27.7 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.