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Search of human proteins with 239743649
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|239743649 PREDICTED: IQ motif and ankyrin repeat
domain-containing protein LOC642574 [Homo sapiens]
(580 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|239743649 PREDICTED: IQ motif and ankyrin repeat domain-conta... 1149 0.0
gi|239754976 PREDICTED: IQ motif and ankyrin repeat domain-conta... 882 0.0
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 66 1e-10
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 66 1e-10
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 66 1e-10
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 66 1e-10
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 66 1e-10
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 66 1e-10
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 66 1e-10
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 66 1e-10
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens] 60 4e-09
gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens] 60 5e-09
gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens] 60 5e-09
gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens] 60 5e-09
gi|22208951 ankyrin repeat and SOCS box-containing protein 3 iso... 59 2e-08
gi|7705831 ankyrin repeat and SOCS box-containing protein 3 isof... 59 2e-08
gi|157738667 FYVE and coiled-coil domain containing 1 [Homo sapi... 57 5e-08
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] 57 6e-08
gi|56676397 ankyrin repeat domain 11 [Homo sapiens] 57 6e-08
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens] 56 8e-08
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens] 56 8e-08
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens] 56 8e-08
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens] 56 8e-08
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens] 56 8e-08
gi|148746195 trichohyalin [Homo sapiens] 55 1e-07
gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 55 2e-07
gi|30348954 mindbomb homolog 1 [Homo sapiens] 54 5e-07
gi|90186267 ankyrin repeat domain 55 isoform 1 [Homo sapiens] 54 5e-07
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] 53 7e-07
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens] 53 7e-07
>gi|239743649 PREDICTED: IQ motif and ankyrin repeat
domain-containing protein LOC642574 [Homo sapiens]
Length = 580
Score = 1149 bits (2971), Expect = 0.0
Identities = 580/580 (100%), Positives = 580/580 (100%)
Query: 1 MQEGPSAFREGCPAGDSTPSSPFLGAPELRARRGSQDPRRRGAGEVPADLGPLRVPGSRA 60
MQEGPSAFREGCPAGDSTPSSPFLGAPELRARRGSQDPRRRGAGEVPADLGPLRVPGSRA
Sbjct: 1 MQEGPSAFREGCPAGDSTPSSPFLGAPELRARRGSQDPRRRGAGEVPADLGPLRVPGSRA 60
Query: 61 ASSCGLCGREPRLGRAGGFESRPAEDRAARAIQGAFRQLRARRELARRREERREYLEQME 120
ASSCGLCGREPRLGRAGGFESRPAEDRAARAIQGAFRQLRARRELARRREERREYLEQME
Sbjct: 61 ASSCGLCGREPRLGRAGGFESRPAEDRAARAIQGAFRQLRARRELARRREERREYLEQME 120
Query: 121 TPQKEAYLAPVRREQEAARRLREQEEAAQRERREELQRRRRLLDAAFDGDVGEIRAVLKE 180
TPQKEAYLAPVRREQEAARRLREQEEAAQRERREELQRRRRLLDAAFDGDVGEIRAVLKE
Sbjct: 121 TPQKEAYLAPVRREQEAARRLREQEEAAQRERREELQRRRRLLDAAFDGDVGEIRAVLKE 180
Query: 181 VEQLLTREGVGHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGAS 240
VEQLLTREGVGHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGAS
Sbjct: 181 VEQLLTREGVGHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGAS 240
Query: 241 PNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVASLDTVVSVLRSW 300
PNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVASLDTVVSVLRSW
Sbjct: 241 PNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVASLDTVVSVLRSW 300
Query: 301 DLSLTEAMLQNMEAEQQRRAQEAQRHKEAEAERMTLKVQQLTREQQQCHKELQQAYCELS 360
DLSLTEAMLQNMEAEQQRRAQEAQRHKEAEAERMTLKVQQLTREQQQCHKELQQAYCELS
Sbjct: 301 DLSLTEAMLQNMEAEQQRRAQEAQRHKEAEAERMTLKVQQLTREQQQCHKELQQAYCELS 360
Query: 361 RRISEHDQCEWRCMDKTKLTLQAIKDTEAQVDRLRQEAQKAEEALAMARLELREQTQEGE 420
RRISEHDQCEWRCMDKTKLTLQAIKDTEAQVDRLRQEAQKAEEALAMARLELREQTQEGE
Sbjct: 361 RRISEHDQCEWRCMDKTKLTLQAIKDTEAQVDRLRQEAQKAEEALAMARLELREQTQEGE 420
Query: 421 EEAPGLKCQVTELHDVLMKDVGNRIRADGRWPLVIDPLGQAATFLRYQDTNYVDTVNPEP 480
EEAPGLKCQVTELHDVLMKDVGNRIRADGRWPLVIDPLGQAATFLRYQDTNYVDTVNPEP
Sbjct: 421 EEAPGLKCQVTELHDVLMKDVGNRIRADGRWPLVIDPLGQAATFLRYQDTNYVDTVNPEP 480
Query: 481 LRPETMWLALLGALRYGKPLVFDLREEDLFPVVQRQLEAVQERYLSLLRPTDGPEYSPTQ 540
LRPETMWLALLGALRYGKPLVFDLREEDLFPVVQRQLEAVQERYLSLLRPTDGPEYSPTQ
Sbjct: 481 LRPETMWLALLGALRYGKPLVFDLREEDLFPVVQRQLEAVQERYLSLLRPTDGPEYSPTQ 540
Query: 541 FQEQRLEHFRLFFVTKVQWPPAEQLQVLLPVRVQLPGTGL 580
FQEQRLEHFRLFFVTKVQWPPAEQLQVLLPVRVQLPGTGL
Sbjct: 541 FQEQRLEHFRLFFVTKVQWPPAEQLQVLLPVRVQLPGTGL 580
>gi|239754976 PREDICTED: IQ motif and ankyrin repeat
domain-containing protein LOC642574 [Homo sapiens]
Length = 484
Score = 882 bits (2279), Expect = 0.0
Identities = 471/580 (81%), Positives = 476/580 (82%), Gaps = 96/580 (16%)
Query: 1 MQEGPSAFREGCPAGDSTPSSPFLGAPELRARRGSQDPRRRGAGEVPADLGPLRVPGSRA 60
MQEGPSAFREGCPAGDSTPSSPFLGAPELRARRGSQDPRRR
Sbjct: 1 MQEGPSAFREGCPAGDSTPSSPFLGAPELRARRGSQDPRRR------------------- 41
Query: 61 ASSCGLCGREPRLGRAGGFESRPAEDRAARAIQGAFRQLRARRELARRREERREYLEQME 120
PAEDRAARAIQGAFRQLRAR
Sbjct: 42 ----------------------PAEDRAARAIQGAFRQLRAR------------------ 61
Query: 121 TPQKEAYLAPVRREQEAARRLREQEEAAQRERREELQRRRRLLDAAFDGDVGEIRAVLKE 180
+E ARR + ERRE L+ ++ KE
Sbjct: 62 --------------RELARR--------REERREYLE---------------QMETPQKE 84
Query: 181 VEQLLTREGVGHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGAS 240
VEQLLTREGVGHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGAS
Sbjct: 85 VEQLLTREGVGHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGAS 144
Query: 241 PNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVASLDTVVSVLRSW 300
PNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVASLDTVVSVLRSW
Sbjct: 145 PNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVASLDTVVSVLRSW 204
Query: 301 DLSLTEAMLQNMEAEQQRRAQEAQRHKEAEAERMTLKVQQLTREQQQCHKELQQAYCELS 360
DLSLTEAMLQNMEAEQQRRAQEAQRHKEAEAERMTLKVQQLTREQQQCHKELQQAYCELS
Sbjct: 205 DLSLTEAMLQNMEAEQQRRAQEAQRHKEAEAERMTLKVQQLTREQQQCHKELQQAYCELS 264
Query: 361 RRISEHDQCEWRCMDKTKLTLQAIKDTEAQVDRLRQEAQKAEEALAMARLELREQTQEGE 420
RRISEHDQCEWRCMDKTKLTLQAIKDTEAQVDRLRQEAQKAEEALAMARLELREQTQEGE
Sbjct: 265 RRISEHDQCEWRCMDKTKLTLQAIKDTEAQVDRLRQEAQKAEEALAMARLELREQTQEGE 324
Query: 421 EEAPGLKCQVTELHDVLMKDVGNRIRADGRWPLVIDPLGQAATFLRYQDTNYVDTVNPEP 480
EEAPGLKCQVTELHDVLMKDVGNRIRADGRWPLVIDPLGQAATFLRYQDTNYVDTVNPEP
Sbjct: 325 EEAPGLKCQVTELHDVLMKDVGNRIRADGRWPLVIDPLGQAATFLRYQDTNYVDTVNPEP 384
Query: 481 LRPETMWLALLGALRYGKPLVFDLREEDLFPVVQRQLEAVQERYLSLLRPTDGPEYSPTQ 540
LRPE MWLALLGALRYGKPLVFDLREEDLFPVVQRQLEAVQERYLSLLRPTDGPEYSPTQ
Sbjct: 385 LRPERMWLALLGALRYGKPLVFDLREEDLFPVVQRQLEAVQERYLSLLRPTDGPEYSPTQ 444
Query: 541 FQEQRLEHFRLFFVTKVQWPPAEQLQVLLPVRVQLPGTGL 580
FQEQRLEHFRLFFVTKVQWPPAEQLQVLLPVRVQLPGTGL
Sbjct: 445 FQEQRLEHFRLFFVTKVQWPPAEQLQVLLPVRVQLPGTGL 484
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 65.9 bits (159), Expect = 1e-10
Identities = 93/381 (24%), Positives = 166/381 (43%), Gaps = 48/381 (12%)
Query: 80 ESRPAEDRAARAIQ---GAFRQL-------RARRELARRREERREYLEQMETPQKEAYLA 129
ESR +++ + ++ G FR+L RA E A+R+ + E + + E LA
Sbjct: 1777 ESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLA 1836
Query: 130 PVRREQEAARRLREQEEAAQRERREELQRRRRLL-DAAFD------------GDVGEIRA 176
A RL+ + E A +E+ E +R RRL D AF D+ E A
Sbjct: 1837 EKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLA 1896
Query: 177 VLKEV--EQLLTREGVGHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLR 234
L++ +L ++G+ D + R+++ + + +AAAG L ++L
Sbjct: 1897 QLRKASDSELERQKGLVEDTLRQRRQVEEEILALKAS-------FEKAAAGKAELELELG 1949
Query: 235 AELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADPRVY----AEDGSTPERVASL 290
+ ++ + L AA LAA E + A+ RV AE+ + +R A+L
Sbjct: 1950 RIRSNAEDTLRSKEQAEL-EAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL 2008
Query: 291 DTVVSVLRSWDLS--LTEAMLQNMEAEQQRRAQEAQRHKEAEAERMTLKVQQLTREQQQC 348
+ V + + + L E Q + Q + AQ+ +AE + VQQ +E QQ
Sbjct: 2009 EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT 2068
Query: 349 HKELQ------QAYCELSRRISEHDQCEWRCMDKTKLTLQAIKDTEAQVDRLRQEAQKAE 402
++ Q + E +RR +E + E + + Q+ + E + +RL+Q A++
Sbjct: 2069 LQQEQSVLDQLRGEAEAARRAAE--EAEEARVQAEREAAQSRRQVE-EAERLKQSAEEQA 2125
Query: 403 EALAMARLELREQTQEGEEEA 423
+A A A+ + +E E+EA
Sbjct: 2126 QARAQAQAAAEKLRKEAEQEA 2146
Score = 62.4 bits (150), Expect = 1e-09
Identities = 84/346 (24%), Positives = 139/346 (40%), Gaps = 45/346 (13%)
Query: 121 TPQKEAYLAPVRREQEAARRLREQEEAAQRERREE----LQRRRRLLDAAFDGDVGEIRA 176
T Q +++ R E RL EQ+ A +RER E L+++R+L +A R
Sbjct: 1330 TSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAERE 1389
Query: 177 VLKEVEQLLTREGVGHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQ---- 232
KE++Q + E V +EA + Q+R E + ++ A Q A +
Sbjct: 1390 A-KELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRL 1448
Query: 233 --------LRAELGASPNSK-GAFGPTPLYRAAFGGHLAAVEVLLKLGADPRVYAEDGST 283
+R +L A+ + GA G RA A + R +D S
Sbjct: 1449 RIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQ 1508
Query: 284 PERVASLDTVVSVLRSWDL---------SLTEAMLQNMEAEQQRRAQEAQR--------- 325
+R A ++ V + +L E LQ EAE++ R E +R
Sbjct: 1509 RKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALE 1568
Query: 326 --HKEAEAERMTL------KVQQLTREQQQCHKELQQAYCELSRRISEHDQCEWRCMDKT 377
+ AEAE + K QL R Q+ H + Q E RR + + E R ++
Sbjct: 1569 TAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAE-RAREEA 1627
Query: 378 KLTLQAIKDTEAQVDRLRQEAQKAEEALAMARLELREQTQEGEEEA 423
+ L+ + + RLR +A++ + ++A+ E +Q +E E EA
Sbjct: 1628 ERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREA 1673
Score = 60.8 bits (146), Expect = 3e-09
Identities = 100/457 (21%), Positives = 186/457 (40%), Gaps = 74/457 (16%)
Query: 28 ELRARRGSQDPRRRGAGEVPADLGPLRVPGS---RAASSCGL-CGREPRLGRAGGFESRP 83
E+ A + S + G E+ +LG +R R+ L R+ +L R
Sbjct: 1926 EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRRE 1985
Query: 84 AEDRAARAIQGAFRQLRARRELARRREERREYLEQMETPQKEAYLAPVRREQEAARRLRE 143
AE+R ++ L A E AR+R+ E +E+++ +EA R EQE+AR+L+
Sbjct: 1986 AEERVQKS-------LAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQL 2038
Query: 144 QEEAAQR--------------ERREELQRRRRLLDAAFDGDVGEIRAVLKEVEQLLTREG 189
+EAAQ+ ++ +ELQ+ + + D GE A + E+
Sbjct: 2039 AQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARV 2098
Query: 190 VGHDEAGEARR-LQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFG 248
EA ++RR ++ L + + ++A A Q A +LR E +
Sbjct: 2099 QAEREAAQSRRQVEEAERLKQSAEEQ-----AQARAQAQAAAEKLRKEAEQEAARRAQAE 2153
Query: 249 PTPLYR-----AAFGGHLAAVEVLLKLGADP-------RVYAEDGSTPERVASLDTVVSV 296
L + A H E L+ A R+ E+ T + LD +
Sbjct: 2154 QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE--TDHQKNLLDEELQR 2211
Query: 297 LRSWDLSLTEAMLQNMEAEQQRRAQEAQRHK--------EAEAERMTLK----VQQLTRE 344
L++ TEA Q + E++ + Q + EAE + L+ Q+ +E
Sbjct: 2212 LKA---EATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQE 2268
Query: 345 QQQCHKELQQAYCELS---------RRISEHDQCEWRCMDKTKL--TLQAIKDT---EAQ 390
+ + K++ + LS R+++E D + R + + L +QA+++ +A+
Sbjct: 2269 EAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAE 2328
Query: 391 VDRLRQEAQKAEEALAMARLELREQTQEGEEEAPGLK 427
+ L+Q+ + A+E + + + Q+ EE G +
Sbjct: 2329 AELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQ 2365
Score = 56.2 bits (134), Expect = 8e-08
Identities = 80/342 (23%), Positives = 147/342 (42%), Gaps = 26/342 (7%)
Query: 84 AEDRAARAIQGAFRQLRARRELARRR-EERREYLEQMETPQKEAYLAPVRRE--QEAARR 140
A AAR Q A L +R LA + +E+ + +++ + EA L ++E QE ARR
Sbjct: 2286 AAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARR 2345
Query: 141 LREQEEAAQRERREELQRRRRLLDAAFDGDVGEIRAVLKEVEQLLTREGVGHDEAGEARR 200
L+E +E ++ EE Q +R L+A + E+ A E E+L R V +AR
Sbjct: 2346 LQEDKEQMAQQLAEETQGFQRTLEAERQRQL-EMSA---EAERLKLR--VAEMSRAQARA 2399
Query: 201 LQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGH 260
+ + + G A + + + E+ + A R A
Sbjct: 2400 EEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDA----ERLREAIAEL 2455
Query: 261 LAAVEVLLKLGADPRVYAEDGSTPERVASLDTVVSVLRSWDLSLTEAMLQNMEAEQQRRA 320
E L + ++ +E+ T ++ L ++ +S+ LS +++LQ +Q +A
Sbjct: 2456 EREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSF-LSEKDSLLQRERFIEQEKA 2514
Query: 321 QEAQRHKEAEAERMTLKVQQLTREQQQCHKELQQAYCELSRRISEHDQCEWRCMDKTKLT 380
+ Q ++ A+ L+ +Q R+QQQ +E Q+ + + E
Sbjct: 2515 KLEQLFQDEVAKAQQLREEQ-QRQQQQMEQERQRLVASMEEARRRQHEAE---------- 2563
Query: 381 LQAIKDTEAQVDRLRQEAQKAEEALAMARLELREQTQEGEEE 422
+ ++ + ++ +L Q+ ++ EE LA LREQ Q EE+
Sbjct: 2564 -EGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2604
Score = 53.1 bits (126), Expect = 7e-07
Identities = 96/432 (22%), Positives = 162/432 (37%), Gaps = 50/432 (11%)
Query: 28 ELRARRGSQDPRRRGAGEVPADLGPLRVPGSRAASSCGLCGREPRLGRAGGFESRPAEDR 87
E+R R + R G +L LR A + E R R +D
Sbjct: 1453 EIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLR------RQVQDE 1506
Query: 88 AARAIQGAFR---QLRARRELARRREERREYLEQMETPQKEAYLAPVRREQEAARRLREQ 144
+ R Q +++A E AR ++ + LE++ +EA + E E AR+++
Sbjct: 1507 SQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVA 1566
Query: 145 EEAAQRERREELQRRRRLLDAAFDGDVGEIRAVLKE----VEQLLTREGVGHDEAGEARR 200
E AQR ELQ +R A+F ++ L+E V QL + EA R
Sbjct: 1567 LETAQRSAEAELQSKR----ASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAER 1622
Query: 201 LQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGH 260
+ AE E +EA L ++L+AE A S
Sbjct: 1623 AREE---AERELERWQLKANEA------LRLRLQAEEVAQQKS----------------- 1656
Query: 261 LAAVEVLLKLGADPRVYAEDGSTPERVASLDTVVSVLRSWDLSLTEAMLQNMEAEQQRRA 320
LA E + R G E+ + L E Q A +Q
Sbjct: 1657 LAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELI 1716
Query: 321 QEAQRHKEAEAERMTL--KVQQLTREQQQCHKELQQAYCELSRRISEHD---QCEWRCMD 375
+ ++ E +R L ++ +L RE ++ Q+ EL++ +E + + R +
Sbjct: 1717 RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE 1776
Query: 376 KTKLTLQAIKD-TEAQVDRLRQEAQKAEEALAMARLELREQTQEGEEEAPGLKCQVTELH 434
+++ T + K EA+ R R+ A++A A+A E + Q Q EE+A + + +
Sbjct: 1777 ESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE-EAKRQRQLAEEDAARQRAEAERVL 1835
Query: 435 DVLMKDVGNRIR 446
+ +G R
Sbjct: 1836 AEKLAAIGEATR 1847
Score = 50.4 bits (119), Expect = 4e-06
Identities = 81/387 (20%), Positives = 148/387 (38%), Gaps = 43/387 (11%)
Query: 80 ESRPAEDRAARAIQGAFRQLRARRELARRREERREYLEQMETPQKEAYLAPVRREQEAAR 139
+SR + A R Q A Q +AR + E+ R+ EQ + +A A +R++Q A
Sbjct: 2106 QSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADA 2165
Query: 140 RLR----------------EQEEAAQRERREELQRRRRLLDAAFD---GDVGEIRAVLKE 180
+ EQE R + EE ++ LLD + E +
Sbjct: 2166 EMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQ 2225
Query: 181 VEQLLTREGVGHDEAGEAR---RLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAEL 237
VE+ L V +E + + + R + +D+ EA Q R +
Sbjct: 2226 VEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSV 2285
Query: 238 GASPNSK-------GAFGPTPLYRAAFGGHLAAVEVLLKLGADPRVYAEDGS-TPERVAS 289
A ++ L + AV+ +L A+ + + E+
Sbjct: 2286 AAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARR 2345
Query: 290 LDTVVSVLRSWDLSLTEAMLQNMEAEQQRRAQEAQRHKEAEAERMTLKVQQLTREQQQCH 349
L + T+ + +EAE+QR Q AEAER+ L+V +++R Q +
Sbjct: 2346 LQEDKEQMAQQLAEETQGFQRTLEAERQR-----QLEMSAEAERLKLRVAEMSRAQARAE 2400
Query: 350 KELQQAYCELSRRISEHDQCEWRCMDKTKLTLQAIKDTEAQVDRLRQEAQKAEEALAMAR 409
++ Q+ + + + I E + +T+L Q ++ RQ++ E L A
Sbjct: 2401 EDAQR-FRKQAEEIGEK-------LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAI 2452
Query: 410 LELREQTQEGEEEAPGLKCQVTELHDV 436
EL + ++ ++EA L+ + E+ V
Sbjct: 2453 AELEREKEKLQQEAKLLQLKSEEMQTV 2479
Score = 40.0 bits (92), Expect = 0.006
Identities = 86/376 (22%), Positives = 139/376 (36%), Gaps = 60/376 (15%)
Query: 90 RAIQGAFRQLRARRELARRREERREYLEQMETPQKEAYLAPVRREQEAAR----RLREQE 145
R QGA LRA E + + L ++E + A L +R + EA + LR++
Sbjct: 1096 RGTQGAEEVLRAHEEQLKEAQAVPATLPELEATK--ASLKKLRAQAEAQQPTFDALRDEL 1153
Query: 146 EAAQRERREELQRRRRLLDAAFDGDVGEIRAVLKEVEQLLTREGVGH---DEAGEARRLQ 202
AQ E E LQ+R D + + +L+ + +L + V ++ G R
Sbjct: 1154 RGAQ-EVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYY 1212
Query: 203 RRVAL---AECEDSYGNTPLSEAA--AGGQPLAIQLRAELGASPN--------------S 243
R A A +D+ +A A Q + QLR E +
Sbjct: 1213 RESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFA 1272
Query: 244 KGAFGPTPLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVASLDTVVS---VLRSW 300
K Y + A +E + P+V + S + L T S L S
Sbjct: 1273 KQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQ 1332
Query: 301 DLSLTEAMLQNMEAEQ----QRRAQEAQRHKEAEAERMTLKVQQLTREQQQCHKELQQAY 356
+ L+ ME E+ Q+RA+E R + AE E K +QL Q + ++
Sbjct: 1333 YIKFISETLRRMEEEERLAEQQRAEE--RERLAEVEAALEKQRQLAEAHAQAKAQAEREA 1390
Query: 357 CELSRRISEHDQCEWRCMDKTKLTLQAIKDTEAQVDRLRQEAQKAEEALAMARLELREQT 416
EL +R+ E + ++ EA VD +Q+ EE L+ Q+
Sbjct: 1391 KELQQRMQE----------------EVVRREEAAVDAQQQKRSIQEE------LQQLRQS 1428
Query: 417 QEGEEEAPGLKCQVTE 432
E E +A + + E
Sbjct: 1429 SEAEIQAKARQAEAAE 1444
Score = 32.7 bits (73), Expect = 0.94
Identities = 30/104 (28%), Positives = 46/104 (44%), Gaps = 20/104 (19%)
Query: 109 REERREYLEQMETPQKEAYLAPVRREQEAARRLREQEEAAQRERREELQRRRRLLDAAFD 168
REE++ +QME ++ V +EA RR E EE +R ++EELQ
Sbjct: 2531 REEQQRQQQQMEQERQRL----VASMEEARRRQHEAEEGVRR-KQEELQ----------- 2574
Query: 169 GDVGEIRAVLKEVEQLLTREGVGHDEAGEARRLQRRVALAECED 212
++ ++ E+LL E E + Q R ALA E+
Sbjct: 2575 ----QLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEE 2614
Score = 32.0 bits (71), Expect = 1.6
Identities = 20/68 (29%), Positives = 31/68 (45%)
Query: 87 RAARAIQGAFRQLRARRELARRREERREYLEQMETPQKEAYLAPVRREQEAARRLREQEE 146
R +++ A R+ E RR++E + LEQ Q+E +R +E + L EQ
Sbjct: 2547 RLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHR 2606
Query: 147 AAQRERRE 154
AA E
Sbjct: 2607 AALAHSEE 2614
Score = 31.6 bits (70), Expect = 2.1
Identities = 40/151 (26%), Positives = 62/151 (41%), Gaps = 25/151 (16%)
Query: 289 SLDTVVSVLRSWDLSLTEAMLQNMEAEQQRRAQEA-QRHKEA------------EAERMT 335
SL V ++RSW L A + ++ E+QR+A + + H +A +R+
Sbjct: 898 SLRRDVQLIRSWSL----ATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLM 953
Query: 336 LKVQQLTREQQQCHKELQQAYCELSRRISEHDQCEWRCMDKTK-LTLQAIKDTEAQVDRL 394
+ RE C QQ L + E +C+ RC+ + K + LQ V RL
Sbjct: 954 AE-----REYGSCSHHYQQLLQSLEQGAQEESRCQ-RCISELKDIRLQLEACETRTVHRL 1007
Query: 395 RQEAQKAEEALAMARLELREQTQEGEEEAPG 425
R K E A A+ +Q + E E G
Sbjct: 1008 RLPLDK-EPARECAQRIAEQQKAQAEVEGLG 1037
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 65.9 bits (159), Expect = 1e-10
Identities = 93/381 (24%), Positives = 166/381 (43%), Gaps = 48/381 (12%)
Query: 80 ESRPAEDRAARAIQ---GAFRQL-------RARRELARRREERREYLEQMETPQKEAYLA 129
ESR +++ + ++ G FR+L RA E A+R+ + E + + E LA
Sbjct: 1781 ESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLA 1840
Query: 130 PVRREQEAARRLREQEEAAQRERREELQRRRRLL-DAAFD------------GDVGEIRA 176
A RL+ + E A +E+ E +R RRL D AF D+ E A
Sbjct: 1841 EKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLA 1900
Query: 177 VLKEV--EQLLTREGVGHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLR 234
L++ +L ++G+ D + R+++ + + +AAAG L ++L
Sbjct: 1901 QLRKASDSELERQKGLVEDTLRQRRQVEEEILALKAS-------FEKAAAGKAELELELG 1953
Query: 235 AELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADPRVY----AEDGSTPERVASL 290
+ ++ + L AA LAA E + A+ RV AE+ + +R A+L
Sbjct: 1954 RIRSNAEDTLRSKEQAEL-EAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL 2012
Query: 291 DTVVSVLRSWDLS--LTEAMLQNMEAEQQRRAQEAQRHKEAEAERMTLKVQQLTREQQQC 348
+ V + + + L E Q + Q + AQ+ +AE + VQQ +E QQ
Sbjct: 2013 EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT 2072
Query: 349 HKELQ------QAYCELSRRISEHDQCEWRCMDKTKLTLQAIKDTEAQVDRLRQEAQKAE 402
++ Q + E +RR +E + E + + Q+ + E + +RL+Q A++
Sbjct: 2073 LQQEQSVLDQLRGEAEAARRAAE--EAEEARVQAEREAAQSRRQVE-EAERLKQSAEEQA 2129
Query: 403 EALAMARLELREQTQEGEEEA 423
+A A A+ + +E E+EA
Sbjct: 2130 QARAQAQAAAEKLRKEAEQEA 2150
Score = 62.4 bits (150), Expect = 1e-09
Identities = 84/346 (24%), Positives = 139/346 (40%), Gaps = 45/346 (13%)
Query: 121 TPQKEAYLAPVRREQEAARRLREQEEAAQRERREE----LQRRRRLLDAAFDGDVGEIRA 176
T Q +++ R E RL EQ+ A +RER E L+++R+L +A R
Sbjct: 1334 TSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAERE 1393
Query: 177 VLKEVEQLLTREGVGHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQ---- 232
KE++Q + E V +EA + Q+R E + ++ A Q A +
Sbjct: 1394 A-KELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRL 1452
Query: 233 --------LRAELGASPNSK-GAFGPTPLYRAAFGGHLAAVEVLLKLGADPRVYAEDGST 283
+R +L A+ + GA G RA A + R +D S
Sbjct: 1453 RIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQ 1512
Query: 284 PERVASLDTVVSVLRSWDL---------SLTEAMLQNMEAEQQRRAQEAQR--------- 325
+R A ++ V + +L E LQ EAE++ R E +R
Sbjct: 1513 RKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALE 1572
Query: 326 --HKEAEAERMTL------KVQQLTREQQQCHKELQQAYCELSRRISEHDQCEWRCMDKT 377
+ AEAE + K QL R Q+ H + Q E RR + + E R ++
Sbjct: 1573 TAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAE-RAREEA 1631
Query: 378 KLTLQAIKDTEAQVDRLRQEAQKAEEALAMARLELREQTQEGEEEA 423
+ L+ + + RLR +A++ + ++A+ E +Q +E E EA
Sbjct: 1632 ERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREA 1677
Score = 60.8 bits (146), Expect = 3e-09
Identities = 100/457 (21%), Positives = 186/457 (40%), Gaps = 74/457 (16%)
Query: 28 ELRARRGSQDPRRRGAGEVPADLGPLRVPGS---RAASSCGL-CGREPRLGRAGGFESRP 83
E+ A + S + G E+ +LG +R R+ L R+ +L R
Sbjct: 1930 EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRRE 1989
Query: 84 AEDRAARAIQGAFRQLRARRELARRREERREYLEQMETPQKEAYLAPVRREQEAARRLRE 143
AE+R ++ L A E AR+R+ E +E+++ +EA R EQE+AR+L+
Sbjct: 1990 AEERVQKS-------LAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQL 2042
Query: 144 QEEAAQR--------------ERREELQRRRRLLDAAFDGDVGEIRAVLKEVEQLLTREG 189
+EAAQ+ ++ +ELQ+ + + D GE A + E+
Sbjct: 2043 AQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARV 2102
Query: 190 VGHDEAGEARR-LQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFG 248
EA ++RR ++ L + + ++A A Q A +LR E +
Sbjct: 2103 QAEREAAQSRRQVEEAERLKQSAEEQ-----AQARAQAQAAAEKLRKEAEQEAARRAQAE 2157
Query: 249 PTPLYR-----AAFGGHLAAVEVLLKLGADP-------RVYAEDGSTPERVASLDTVVSV 296
L + A H E L+ A R+ E+ T + LD +
Sbjct: 2158 QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE--TDHQKNLLDEELQR 2215
Query: 297 LRSWDLSLTEAMLQNMEAEQQRRAQEAQRHK--------EAEAERMTLK----VQQLTRE 344
L++ TEA Q + E++ + Q + EAE + L+ Q+ +E
Sbjct: 2216 LKA---EATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQE 2272
Query: 345 QQQCHKELQQAYCELS---------RRISEHDQCEWRCMDKTKL--TLQAIKDT---EAQ 390
+ + K++ + LS R+++E D + R + + L +QA+++ +A+
Sbjct: 2273 EAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAE 2332
Query: 391 VDRLRQEAQKAEEALAMARLELREQTQEGEEEAPGLK 427
+ L+Q+ + A+E + + + Q+ EE G +
Sbjct: 2333 AELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQ 2369
Score = 56.2 bits (134), Expect = 8e-08
Identities = 80/342 (23%), Positives = 147/342 (42%), Gaps = 26/342 (7%)
Query: 84 AEDRAARAIQGAFRQLRARRELARRR-EERREYLEQMETPQKEAYLAPVRRE--QEAARR 140
A AAR Q A L +R LA + +E+ + +++ + EA L ++E QE ARR
Sbjct: 2290 AAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARR 2349
Query: 141 LREQEEAAQRERREELQRRRRLLDAAFDGDVGEIRAVLKEVEQLLTREGVGHDEAGEARR 200
L+E +E ++ EE Q +R L+A + E+ A E E+L R V +AR
Sbjct: 2350 LQEDKEQMAQQLAEETQGFQRTLEAERQRQL-EMSA---EAERLKLR--VAEMSRAQARA 2403
Query: 201 LQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGH 260
+ + + G A + + + E+ + A R A
Sbjct: 2404 EEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDA----ERLREAIAEL 2459
Query: 261 LAAVEVLLKLGADPRVYAEDGSTPERVASLDTVVSVLRSWDLSLTEAMLQNMEAEQQRRA 320
E L + ++ +E+ T ++ L ++ +S+ LS +++LQ +Q +A
Sbjct: 2460 EREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSF-LSEKDSLLQRERFIEQEKA 2518
Query: 321 QEAQRHKEAEAERMTLKVQQLTREQQQCHKELQQAYCELSRRISEHDQCEWRCMDKTKLT 380
+ Q ++ A+ L+ +Q R+QQQ +E Q+ + + E
Sbjct: 2519 KLEQLFQDEVAKAQQLREEQ-QRQQQQMEQERQRLVASMEEARRRQHEAE---------- 2567
Query: 381 LQAIKDTEAQVDRLRQEAQKAEEALAMARLELREQTQEGEEE 422
+ ++ + ++ +L Q+ ++ EE LA LREQ Q EE+
Sbjct: 2568 -EGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2608
Score = 53.1 bits (126), Expect = 7e-07
Identities = 96/432 (22%), Positives = 162/432 (37%), Gaps = 50/432 (11%)
Query: 28 ELRARRGSQDPRRRGAGEVPADLGPLRVPGSRAASSCGLCGREPRLGRAGGFESRPAEDR 87
E+R R + R G +L LR A + E R R +D
Sbjct: 1457 EIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLR------RQVQDE 1510
Query: 88 AARAIQGAFR---QLRARRELARRREERREYLEQMETPQKEAYLAPVRREQEAARRLREQ 144
+ R Q +++A E AR ++ + LE++ +EA + E E AR+++
Sbjct: 1511 SQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVA 1570
Query: 145 EEAAQRERREELQRRRRLLDAAFDGDVGEIRAVLKE----VEQLLTREGVGHDEAGEARR 200
E AQR ELQ +R A+F ++ L+E V QL + EA R
Sbjct: 1571 LETAQRSAEAELQSKR----ASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAER 1626
Query: 201 LQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGH 260
+ AE E +EA L ++L+AE A S
Sbjct: 1627 AREE---AERELERWQLKANEA------LRLRLQAEEVAQQKS----------------- 1660
Query: 261 LAAVEVLLKLGADPRVYAEDGSTPERVASLDTVVSVLRSWDLSLTEAMLQNMEAEQQRRA 320
LA E + R G E+ + L E Q A +Q
Sbjct: 1661 LAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELI 1720
Query: 321 QEAQRHKEAEAERMTL--KVQQLTREQQQCHKELQQAYCELSRRISEHD---QCEWRCMD 375
+ ++ E +R L ++ +L RE ++ Q+ EL++ +E + + R +
Sbjct: 1721 RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE 1780
Query: 376 KTKLTLQAIKD-TEAQVDRLRQEAQKAEEALAMARLELREQTQEGEEEAPGLKCQVTELH 434
+++ T + K EA+ R R+ A++A A+A E + Q Q EE+A + + +
Sbjct: 1781 ESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE-EAKRQRQLAEEDAARQRAEAERVL 1839
Query: 435 DVLMKDVGNRIR 446
+ +G R
Sbjct: 1840 AEKLAAIGEATR 1851
Score = 50.4 bits (119), Expect = 4e-06
Identities = 81/387 (20%), Positives = 148/387 (38%), Gaps = 43/387 (11%)
Query: 80 ESRPAEDRAARAIQGAFRQLRARRELARRREERREYLEQMETPQKEAYLAPVRREQEAAR 139
+SR + A R Q A Q +AR + E+ R+ EQ + +A A +R++Q A
Sbjct: 2110 QSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADA 2169
Query: 140 RLR----------------EQEEAAQRERREELQRRRRLLDAAFD---GDVGEIRAVLKE 180
+ EQE R + EE ++ LLD + E +
Sbjct: 2170 EMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQ 2229
Query: 181 VEQLLTREGVGHDEAGEAR---RLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAEL 237
VE+ L V +E + + + R + +D+ EA Q R +
Sbjct: 2230 VEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSV 2289
Query: 238 GASPNSK-------GAFGPTPLYRAAFGGHLAAVEVLLKLGADPRVYAEDGS-TPERVAS 289
A ++ L + AV+ +L A+ + + E+
Sbjct: 2290 AAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARR 2349
Query: 290 LDTVVSVLRSWDLSLTEAMLQNMEAEQQRRAQEAQRHKEAEAERMTLKVQQLTREQQQCH 349
L + T+ + +EAE+QR Q AEAER+ L+V +++R Q +
Sbjct: 2350 LQEDKEQMAQQLAEETQGFQRTLEAERQR-----QLEMSAEAERLKLRVAEMSRAQARAE 2404
Query: 350 KELQQAYCELSRRISEHDQCEWRCMDKTKLTLQAIKDTEAQVDRLRQEAQKAEEALAMAR 409
++ Q+ + + + I E + +T+L Q ++ RQ++ E L A
Sbjct: 2405 EDAQR-FRKQAEEIGEK-------LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAI 2456
Query: 410 LELREQTQEGEEEAPGLKCQVTELHDV 436
EL + ++ ++EA L+ + E+ V
Sbjct: 2457 AELEREKEKLQQEAKLLQLKSEEMQTV 2483
Score = 40.0 bits (92), Expect = 0.006
Identities = 86/376 (22%), Positives = 139/376 (36%), Gaps = 60/376 (15%)
Query: 90 RAIQGAFRQLRARRELARRREERREYLEQMETPQKEAYLAPVRREQEAAR----RLREQE 145
R QGA LRA E + + L ++E + A L +R + EA + LR++
Sbjct: 1100 RGTQGAEEVLRAHEEQLKEAQAVPATLPELEATK--ASLKKLRAQAEAQQPTFDALRDEL 1157
Query: 146 EAAQRERREELQRRRRLLDAAFDGDVGEIRAVLKEVEQLLTREGVGH---DEAGEARRLQ 202
AQ E E LQ+R D + + +L+ + +L + V ++ G R
Sbjct: 1158 RGAQ-EVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYY 1216
Query: 203 RRVAL---AECEDSYGNTPLSEAA--AGGQPLAIQLRAELGASPN--------------S 243
R A A +D+ +A A Q + QLR E +
Sbjct: 1217 RESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFA 1276
Query: 244 KGAFGPTPLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVASLDTVVS---VLRSW 300
K Y + A +E + P+V + S + L T S L S
Sbjct: 1277 KQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQ 1336
Query: 301 DLSLTEAMLQNMEAEQ----QRRAQEAQRHKEAEAERMTLKVQQLTREQQQCHKELQQAY 356
+ L+ ME E+ Q+RA+E R + AE E K +QL Q + ++
Sbjct: 1337 YIKFISETLRRMEEEERLAEQQRAEE--RERLAEVEAALEKQRQLAEAHAQAKAQAEREA 1394
Query: 357 CELSRRISEHDQCEWRCMDKTKLTLQAIKDTEAQVDRLRQEAQKAEEALAMARLELREQT 416
EL +R+ E + ++ EA VD +Q+ EE L+ Q+
Sbjct: 1395 KELQQRMQE----------------EVVRREEAAVDAQQQKRSIQEE------LQQLRQS 1432
Query: 417 QEGEEEAPGLKCQVTE 432
E E +A + + E
Sbjct: 1433 SEAEIQAKARQAEAAE 1448
Score = 32.7 bits (73), Expect = 0.94
Identities = 30/104 (28%), Positives = 46/104 (44%), Gaps = 20/104 (19%)
Query: 109 REERREYLEQMETPQKEAYLAPVRREQEAARRLREQEEAAQRERREELQRRRRLLDAAFD 168
REE++ +QME ++ V +EA RR E EE +R ++EELQ
Sbjct: 2535 REEQQRQQQQMEQERQRL----VASMEEARRRQHEAEEGVRR-KQEELQ----------- 2578
Query: 169 GDVGEIRAVLKEVEQLLTREGVGHDEAGEARRLQRRVALAECED 212
++ ++ E+LL E E + Q R ALA E+
Sbjct: 2579 ----QLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEE 2618
Score = 32.0 bits (71), Expect = 1.6
Identities = 20/68 (29%), Positives = 31/68 (45%)
Query: 87 RAARAIQGAFRQLRARRELARRREERREYLEQMETPQKEAYLAPVRREQEAARRLREQEE 146
R +++ A R+ E RR++E + LEQ Q+E +R +E + L EQ
Sbjct: 2551 RLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHR 2610
Query: 147 AAQRERRE 154
AA E
Sbjct: 2611 AALAHSEE 2618
Score = 31.6 bits (70), Expect = 2.1
Identities = 40/151 (26%), Positives = 62/151 (41%), Gaps = 25/151 (16%)
Query: 289 SLDTVVSVLRSWDLSLTEAMLQNMEAEQQRRAQEA-QRHKEA------------EAERMT 335
SL V ++RSW L A + ++ E+QR+A + + H +A +R+
Sbjct: 902 SLRRDVQLIRSWSL----ATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLM 957
Query: 336 LKVQQLTREQQQCHKELQQAYCELSRRISEHDQCEWRCMDKTK-LTLQAIKDTEAQVDRL 394
+ RE C QQ L + E +C+ RC+ + K + LQ V RL
Sbjct: 958 AE-----REYGSCSHHYQQLLQSLEQGAQEESRCQ-RCISELKDIRLQLEACETRTVHRL 1011
Query: 395 RQEAQKAEEALAMARLELREQTQEGEEEAPG 425
R K E A A+ +Q + E E G
Sbjct: 1012 RLPLDK-EPARECAQRIAEQQKAQAEVEGLG 1041
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 65.9 bits (159), Expect = 1e-10
Identities = 93/381 (24%), Positives = 166/381 (43%), Gaps = 48/381 (12%)
Query: 80 ESRPAEDRAARAIQ---GAFRQL-------RARRELARRREERREYLEQMETPQKEAYLA 129
ESR +++ + ++ G FR+L RA E A+R+ + E + + E LA
Sbjct: 1777 ESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLA 1836
Query: 130 PVRREQEAARRLREQEEAAQRERREELQRRRRLL-DAAFD------------GDVGEIRA 176
A RL+ + E A +E+ E +R RRL D AF D+ E A
Sbjct: 1837 EKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLA 1896
Query: 177 VLKEV--EQLLTREGVGHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLR 234
L++ +L ++G+ D + R+++ + + +AAAG L ++L
Sbjct: 1897 QLRKASDSELERQKGLVEDTLRQRRQVEEEILALKAS-------FEKAAAGKAELELELG 1949
Query: 235 AELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADPRVY----AEDGSTPERVASL 290
+ ++ + L AA LAA E + A+ RV AE+ + +R A+L
Sbjct: 1950 RIRSNAEDTLRSKEQAEL-EAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL 2008
Query: 291 DTVVSVLRSWDLS--LTEAMLQNMEAEQQRRAQEAQRHKEAEAERMTLKVQQLTREQQQC 348
+ V + + + L E Q + Q + AQ+ +AE + VQQ +E QQ
Sbjct: 2009 EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT 2068
Query: 349 HKELQ------QAYCELSRRISEHDQCEWRCMDKTKLTLQAIKDTEAQVDRLRQEAQKAE 402
++ Q + E +RR +E + E + + Q+ + E + +RL+Q A++
Sbjct: 2069 LQQEQSVLDQLRGEAEAARRAAE--EAEEARVQAEREAAQSRRQVE-EAERLKQSAEEQA 2125
Query: 403 EALAMARLELREQTQEGEEEA 423
+A A A+ + +E E+EA
Sbjct: 2126 QARAQAQAAAEKLRKEAEQEA 2146
Score = 62.4 bits (150), Expect = 1e-09
Identities = 84/346 (24%), Positives = 139/346 (40%), Gaps = 45/346 (13%)
Query: 121 TPQKEAYLAPVRREQEAARRLREQEEAAQRERREE----LQRRRRLLDAAFDGDVGEIRA 176
T Q +++ R E RL EQ+ A +RER E L+++R+L +A R
Sbjct: 1330 TSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAERE 1389
Query: 177 VLKEVEQLLTREGVGHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQ---- 232
KE++Q + E V +EA + Q+R E + ++ A Q A +
Sbjct: 1390 A-KELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRL 1448
Query: 233 --------LRAELGASPNSK-GAFGPTPLYRAAFGGHLAAVEVLLKLGADPRVYAEDGST 283
+R +L A+ + GA G RA A + R +D S
Sbjct: 1449 RIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQ 1508
Query: 284 PERVASLDTVVSVLRSWDL---------SLTEAMLQNMEAEQQRRAQEAQR--------- 325
+R A ++ V + +L E LQ EAE++ R E +R
Sbjct: 1509 RKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALE 1568
Query: 326 --HKEAEAERMTL------KVQQLTREQQQCHKELQQAYCELSRRISEHDQCEWRCMDKT 377
+ AEAE + K QL R Q+ H + Q E RR + + E R ++
Sbjct: 1569 TAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAE-RAREEA 1627
Query: 378 KLTLQAIKDTEAQVDRLRQEAQKAEEALAMARLELREQTQEGEEEA 423
+ L+ + + RLR +A++ + ++A+ E +Q +E E EA
Sbjct: 1628 ERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREA 1673
Score = 60.8 bits (146), Expect = 3e-09
Identities = 100/457 (21%), Positives = 186/457 (40%), Gaps = 74/457 (16%)
Query: 28 ELRARRGSQDPRRRGAGEVPADLGPLRVPGS---RAASSCGL-CGREPRLGRAGGFESRP 83
E+ A + S + G E+ +LG +R R+ L R+ +L R
Sbjct: 1926 EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRRE 1985
Query: 84 AEDRAARAIQGAFRQLRARRELARRREERREYLEQMETPQKEAYLAPVRREQEAARRLRE 143
AE+R ++ L A E AR+R+ E +E+++ +EA R EQE+AR+L+
Sbjct: 1986 AEERVQKS-------LAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQL 2038
Query: 144 QEEAAQR--------------ERREELQRRRRLLDAAFDGDVGEIRAVLKEVEQLLTREG 189
+EAAQ+ ++ +ELQ+ + + D GE A + E+
Sbjct: 2039 AQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARV 2098
Query: 190 VGHDEAGEARR-LQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFG 248
EA ++RR ++ L + + ++A A Q A +LR E +
Sbjct: 2099 QAEREAAQSRRQVEEAERLKQSAEEQ-----AQARAQAQAAAEKLRKEAEQEAARRAQAE 2153
Query: 249 PTPLYR-----AAFGGHLAAVEVLLKLGADP-------RVYAEDGSTPERVASLDTVVSV 296
L + A H E L+ A R+ E+ T + LD +
Sbjct: 2154 QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE--TDHQKNLLDEELQR 2211
Query: 297 LRSWDLSLTEAMLQNMEAEQQRRAQEAQRHK--------EAEAERMTLK----VQQLTRE 344
L++ TEA Q + E++ + Q + EAE + L+ Q+ +E
Sbjct: 2212 LKA---EATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQE 2268
Query: 345 QQQCHKELQQAYCELS---------RRISEHDQCEWRCMDKTKL--TLQAIKDT---EAQ 390
+ + K++ + LS R+++E D + R + + L +QA+++ +A+
Sbjct: 2269 EAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAE 2328
Query: 391 VDRLRQEAQKAEEALAMARLELREQTQEGEEEAPGLK 427
+ L+Q+ + A+E + + + Q+ EE G +
Sbjct: 2329 AELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQ 2365
Score = 56.2 bits (134), Expect = 8e-08
Identities = 80/342 (23%), Positives = 147/342 (42%), Gaps = 26/342 (7%)
Query: 84 AEDRAARAIQGAFRQLRARRELARRR-EERREYLEQMETPQKEAYLAPVRRE--QEAARR 140
A AAR Q A L +R LA + +E+ + +++ + EA L ++E QE ARR
Sbjct: 2286 AAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARR 2345
Query: 141 LREQEEAAQRERREELQRRRRLLDAAFDGDVGEIRAVLKEVEQLLTREGVGHDEAGEARR 200
L+E +E ++ EE Q +R L+A + E+ A E E+L R V +AR
Sbjct: 2346 LQEDKEQMAQQLAEETQGFQRTLEAERQRQL-EMSA---EAERLKLR--VAEMSRAQARA 2399
Query: 201 LQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGH 260
+ + + G A + + + E+ + A R A
Sbjct: 2400 EEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDA----ERLREAIAEL 2455
Query: 261 LAAVEVLLKLGADPRVYAEDGSTPERVASLDTVVSVLRSWDLSLTEAMLQNMEAEQQRRA 320
E L + ++ +E+ T ++ L ++ +S+ LS +++LQ +Q +A
Sbjct: 2456 EREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSF-LSEKDSLLQRERFIEQEKA 2514
Query: 321 QEAQRHKEAEAERMTLKVQQLTREQQQCHKELQQAYCELSRRISEHDQCEWRCMDKTKLT 380
+ Q ++ A+ L+ +Q R+QQQ +E Q+ + + E
Sbjct: 2515 KLEQLFQDEVAKAQQLREEQ-QRQQQQMEQERQRLVASMEEARRRQHEAE---------- 2563
Query: 381 LQAIKDTEAQVDRLRQEAQKAEEALAMARLELREQTQEGEEE 422
+ ++ + ++ +L Q+ ++ EE LA LREQ Q EE+
Sbjct: 2564 -EGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2604
Score = 53.1 bits (126), Expect = 7e-07
Identities = 96/432 (22%), Positives = 162/432 (37%), Gaps = 50/432 (11%)
Query: 28 ELRARRGSQDPRRRGAGEVPADLGPLRVPGSRAASSCGLCGREPRLGRAGGFESRPAEDR 87
E+R R + R G +L LR A + E R R +D
Sbjct: 1453 EIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLR------RQVQDE 1506
Query: 88 AARAIQGAFR---QLRARRELARRREERREYLEQMETPQKEAYLAPVRREQEAARRLREQ 144
+ R Q +++A E AR ++ + LE++ +EA + E E AR+++
Sbjct: 1507 SQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVA 1566
Query: 145 EEAAQRERREELQRRRRLLDAAFDGDVGEIRAVLKE----VEQLLTREGVGHDEAGEARR 200
E AQR ELQ +R A+F ++ L+E V QL + EA R
Sbjct: 1567 LETAQRSAEAELQSKR----ASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAER 1622
Query: 201 LQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGH 260
+ AE E +EA L ++L+AE A S
Sbjct: 1623 AREE---AERELERWQLKANEA------LRLRLQAEEVAQQKS----------------- 1656
Query: 261 LAAVEVLLKLGADPRVYAEDGSTPERVASLDTVVSVLRSWDLSLTEAMLQNMEAEQQRRA 320
LA E + R G E+ + L E Q A +Q
Sbjct: 1657 LAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELI 1716
Query: 321 QEAQRHKEAEAERMTL--KVQQLTREQQQCHKELQQAYCELSRRISEHD---QCEWRCMD 375
+ ++ E +R L ++ +L RE ++ Q+ EL++ +E + + R +
Sbjct: 1717 RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE 1776
Query: 376 KTKLTLQAIKD-TEAQVDRLRQEAQKAEEALAMARLELREQTQEGEEEAPGLKCQVTELH 434
+++ T + K EA+ R R+ A++A A+A E + Q Q EE+A + + +
Sbjct: 1777 ESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE-EAKRQRQLAEEDAARQRAEAERVL 1835
Query: 435 DVLMKDVGNRIR 446
+ +G R
Sbjct: 1836 AEKLAAIGEATR 1847
Score = 50.4 bits (119), Expect = 4e-06
Identities = 81/387 (20%), Positives = 148/387 (38%), Gaps = 43/387 (11%)
Query: 80 ESRPAEDRAARAIQGAFRQLRARRELARRREERREYLEQMETPQKEAYLAPVRREQEAAR 139
+SR + A R Q A Q +AR + E+ R+ EQ + +A A +R++Q A
Sbjct: 2106 QSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADA 2165
Query: 140 RLR----------------EQEEAAQRERREELQRRRRLLDAAFD---GDVGEIRAVLKE 180
+ EQE R + EE ++ LLD + E +
Sbjct: 2166 EMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQ 2225
Query: 181 VEQLLTREGVGHDEAGEAR---RLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAEL 237
VE+ L V +E + + + R + +D+ EA Q R +
Sbjct: 2226 VEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSV 2285
Query: 238 GASPNSK-------GAFGPTPLYRAAFGGHLAAVEVLLKLGADPRVYAEDGS-TPERVAS 289
A ++ L + AV+ +L A+ + + E+
Sbjct: 2286 AAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARR 2345
Query: 290 LDTVVSVLRSWDLSLTEAMLQNMEAEQQRRAQEAQRHKEAEAERMTLKVQQLTREQQQCH 349
L + T+ + +EAE+QR Q AEAER+ L+V +++R Q +
Sbjct: 2346 LQEDKEQMAQQLAEETQGFQRTLEAERQR-----QLEMSAEAERLKLRVAEMSRAQARAE 2400
Query: 350 KELQQAYCELSRRISEHDQCEWRCMDKTKLTLQAIKDTEAQVDRLRQEAQKAEEALAMAR 409
++ Q+ + + + I E + +T+L Q ++ RQ++ E L A
Sbjct: 2401 EDAQR-FRKQAEEIGEK-------LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAI 2452
Query: 410 LELREQTQEGEEEAPGLKCQVTELHDV 436
EL + ++ ++EA L+ + E+ V
Sbjct: 2453 AELEREKEKLQQEAKLLQLKSEEMQTV 2479
Score = 40.0 bits (92), Expect = 0.006
Identities = 86/376 (22%), Positives = 139/376 (36%), Gaps = 60/376 (15%)
Query: 90 RAIQGAFRQLRARRELARRREERREYLEQMETPQKEAYLAPVRREQEAAR----RLREQE 145
R QGA LRA E + + L ++E + A L +R + EA + LR++
Sbjct: 1096 RGTQGAEEVLRAHEEQLKEAQAVPATLPELEATK--ASLKKLRAQAEAQQPTFDALRDEL 1153
Query: 146 EAAQRERREELQRRRRLLDAAFDGDVGEIRAVLKEVEQLLTREGVGH---DEAGEARRLQ 202
AQ E E LQ+R D + + +L+ + +L + V ++ G R
Sbjct: 1154 RGAQ-EVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYY 1212
Query: 203 RRVAL---AECEDSYGNTPLSEAA--AGGQPLAIQLRAELGASPN--------------S 243
R A A +D+ +A A Q + QLR E +
Sbjct: 1213 RESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFA 1272
Query: 244 KGAFGPTPLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVASLDTVVS---VLRSW 300
K Y + A +E + P+V + S + L T S L S
Sbjct: 1273 KQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQ 1332
Query: 301 DLSLTEAMLQNMEAEQ----QRRAQEAQRHKEAEAERMTLKVQQLTREQQQCHKELQQAY 356
+ L+ ME E+ Q+RA+E R + AE E K +QL Q + ++
Sbjct: 1333 YIKFISETLRRMEEEERLAEQQRAEE--RERLAEVEAALEKQRQLAEAHAQAKAQAEREA 1390
Query: 357 CELSRRISEHDQCEWRCMDKTKLTLQAIKDTEAQVDRLRQEAQKAEEALAMARLELREQT 416
EL +R+ E + ++ EA VD +Q+ EE L+ Q+
Sbjct: 1391 KELQQRMQE----------------EVVRREEAAVDAQQQKRSIQEE------LQQLRQS 1428
Query: 417 QEGEEEAPGLKCQVTE 432
E E +A + + E
Sbjct: 1429 SEAEIQAKARQAEAAE 1444
Score = 32.7 bits (73), Expect = 0.94
Identities = 30/104 (28%), Positives = 46/104 (44%), Gaps = 20/104 (19%)
Query: 109 REERREYLEQMETPQKEAYLAPVRREQEAARRLREQEEAAQRERREELQRRRRLLDAAFD 168
REE++ +QME ++ V +EA RR E EE +R ++EELQ
Sbjct: 2531 REEQQRQQQQMEQERQRL----VASMEEARRRQHEAEEGVRR-KQEELQ----------- 2574
Query: 169 GDVGEIRAVLKEVEQLLTREGVGHDEAGEARRLQRRVALAECED 212
++ ++ E+LL E E + Q R ALA E+
Sbjct: 2575 ----QLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEE 2614
Score = 32.0 bits (71), Expect = 1.6
Identities = 20/68 (29%), Positives = 31/68 (45%)
Query: 87 RAARAIQGAFRQLRARRELARRREERREYLEQMETPQKEAYLAPVRREQEAARRLREQEE 146
R +++ A R+ E RR++E + LEQ Q+E +R +E + L EQ
Sbjct: 2547 RLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHR 2606
Query: 147 AAQRERRE 154
AA E
Sbjct: 2607 AALAHSEE 2614
Score = 31.6 bits (70), Expect = 2.1
Identities = 40/151 (26%), Positives = 62/151 (41%), Gaps = 25/151 (16%)
Query: 289 SLDTVVSVLRSWDLSLTEAMLQNMEAEQQRRAQEA-QRHKEA------------EAERMT 335
SL V ++RSW L A + ++ E+QR+A + + H +A +R+
Sbjct: 898 SLRRDVQLIRSWSL----ATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLM 953
Query: 336 LKVQQLTREQQQCHKELQQAYCELSRRISEHDQCEWRCMDKTK-LTLQAIKDTEAQVDRL 394
+ RE C QQ L + E +C+ RC+ + K + LQ V RL
Sbjct: 954 AE-----REYGSCSHHYQQLLQSLEQGAQEESRCQ-RCISELKDIRLQLEACETRTVHRL 1007
Query: 395 RQEAQKAEEALAMARLELREQTQEGEEEAPG 425
R K E A A+ +Q + E E G
Sbjct: 1008 RLPLDK-EPARECAQRIAEQQKAQAEVEGLG 1037
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 65.9 bits (159), Expect = 1e-10
Identities = 93/381 (24%), Positives = 166/381 (43%), Gaps = 48/381 (12%)
Query: 80 ESRPAEDRAARAIQ---GAFRQL-------RARRELARRREERREYLEQMETPQKEAYLA 129
ESR +++ + ++ G FR+L RA E A+R+ + E + + E LA
Sbjct: 1745 ESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLA 1804
Query: 130 PVRREQEAARRLREQEEAAQRERREELQRRRRLL-DAAFD------------GDVGEIRA 176
A RL+ + E A +E+ E +R RRL D AF D+ E A
Sbjct: 1805 EKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLA 1864
Query: 177 VLKEV--EQLLTREGVGHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLR 234
L++ +L ++G+ D + R+++ + + +AAAG L ++L
Sbjct: 1865 QLRKASDSELERQKGLVEDTLRQRRQVEEEILALKAS-------FEKAAAGKAELELELG 1917
Query: 235 AELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADPRVY----AEDGSTPERVASL 290
+ ++ + L AA LAA E + A+ RV AE+ + +R A+L
Sbjct: 1918 RIRSNAEDTLRSKEQAEL-EAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL 1976
Query: 291 DTVVSVLRSWDLS--LTEAMLQNMEAEQQRRAQEAQRHKEAEAERMTLKVQQLTREQQQC 348
+ V + + + L E Q + Q + AQ+ +AE + VQQ +E QQ
Sbjct: 1977 EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT 2036
Query: 349 HKELQ------QAYCELSRRISEHDQCEWRCMDKTKLTLQAIKDTEAQVDRLRQEAQKAE 402
++ Q + E +RR +E + E + + Q+ + E + +RL+Q A++
Sbjct: 2037 LQQEQSVLDQLRGEAEAARRAAE--EAEEARVQAEREAAQSRRQVE-EAERLKQSAEEQA 2093
Query: 403 EALAMARLELREQTQEGEEEA 423
+A A A+ + +E E+EA
Sbjct: 2094 QARAQAQAAAEKLRKEAEQEA 2114
Score = 62.4 bits (150), Expect = 1e-09
Identities = 84/346 (24%), Positives = 139/346 (40%), Gaps = 45/346 (13%)
Query: 121 TPQKEAYLAPVRREQEAARRLREQEEAAQRERREE----LQRRRRLLDAAFDGDVGEIRA 176
T Q +++ R E RL EQ+ A +RER E L+++R+L +A R
Sbjct: 1298 TSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAERE 1357
Query: 177 VLKEVEQLLTREGVGHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQ---- 232
KE++Q + E V +EA + Q+R E + ++ A Q A +
Sbjct: 1358 A-KELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRL 1416
Query: 233 --------LRAELGASPNSK-GAFGPTPLYRAAFGGHLAAVEVLLKLGADPRVYAEDGST 283
+R +L A+ + GA G RA A + R +D S
Sbjct: 1417 RIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQ 1476
Query: 284 PERVASLDTVVSVLRSWDL---------SLTEAMLQNMEAEQQRRAQEAQR--------- 325
+R A ++ V + +L E LQ EAE++ R E +R
Sbjct: 1477 RKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALE 1536
Query: 326 --HKEAEAERMTL------KVQQLTREQQQCHKELQQAYCELSRRISEHDQCEWRCMDKT 377
+ AEAE + K QL R Q+ H + Q E RR + + E R ++
Sbjct: 1537 TAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAE-RAREEA 1595
Query: 378 KLTLQAIKDTEAQVDRLRQEAQKAEEALAMARLELREQTQEGEEEA 423
+ L+ + + RLR +A++ + ++A+ E +Q +E E EA
Sbjct: 1596 ERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREA 1641
Score = 60.8 bits (146), Expect = 3e-09
Identities = 100/457 (21%), Positives = 186/457 (40%), Gaps = 74/457 (16%)
Query: 28 ELRARRGSQDPRRRGAGEVPADLGPLRVPGS---RAASSCGL-CGREPRLGRAGGFESRP 83
E+ A + S + G E+ +LG +R R+ L R+ +L R
Sbjct: 1894 EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRRE 1953
Query: 84 AEDRAARAIQGAFRQLRARRELARRREERREYLEQMETPQKEAYLAPVRREQEAARRLRE 143
AE+R ++ L A E AR+R+ E +E+++ +EA R EQE+AR+L+
Sbjct: 1954 AEERVQKS-------LAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQL 2006
Query: 144 QEEAAQR--------------ERREELQRRRRLLDAAFDGDVGEIRAVLKEVEQLLTREG 189
+EAAQ+ ++ +ELQ+ + + D GE A + E+
Sbjct: 2007 AQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARV 2066
Query: 190 VGHDEAGEARR-LQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFG 248
EA ++RR ++ L + + ++A A Q A +LR E +
Sbjct: 2067 QAEREAAQSRRQVEEAERLKQSAEEQ-----AQARAQAQAAAEKLRKEAEQEAARRAQAE 2121
Query: 249 PTPLYR-----AAFGGHLAAVEVLLKLGADP-------RVYAEDGSTPERVASLDTVVSV 296
L + A H E L+ A R+ E+ T + LD +
Sbjct: 2122 QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE--TDHQKNLLDEELQR 2179
Query: 297 LRSWDLSLTEAMLQNMEAEQQRRAQEAQRHK--------EAEAERMTLK----VQQLTRE 344
L++ TEA Q + E++ + Q + EAE + L+ Q+ +E
Sbjct: 2180 LKA---EATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQE 2236
Query: 345 QQQCHKELQQAYCELS---------RRISEHDQCEWRCMDKTKL--TLQAIKDT---EAQ 390
+ + K++ + LS R+++E D + R + + L +QA+++ +A+
Sbjct: 2237 EAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAE 2296
Query: 391 VDRLRQEAQKAEEALAMARLELREQTQEGEEEAPGLK 427
+ L+Q+ + A+E + + + Q+ EE G +
Sbjct: 2297 AELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQ 2333
Score = 56.2 bits (134), Expect = 8e-08
Identities = 80/342 (23%), Positives = 147/342 (42%), Gaps = 26/342 (7%)
Query: 84 AEDRAARAIQGAFRQLRARRELARRR-EERREYLEQMETPQKEAYLAPVRRE--QEAARR 140
A AAR Q A L +R LA + +E+ + +++ + EA L ++E QE ARR
Sbjct: 2254 AAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARR 2313
Query: 141 LREQEEAAQRERREELQRRRRLLDAAFDGDVGEIRAVLKEVEQLLTREGVGHDEAGEARR 200
L+E +E ++ EE Q +R L+A + E+ A E E+L R V +AR
Sbjct: 2314 LQEDKEQMAQQLAEETQGFQRTLEAERQRQL-EMSA---EAERLKLR--VAEMSRAQARA 2367
Query: 201 LQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGH 260
+ + + G A + + + E+ + A R A
Sbjct: 2368 EEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDA----ERLREAIAEL 2423
Query: 261 LAAVEVLLKLGADPRVYAEDGSTPERVASLDTVVSVLRSWDLSLTEAMLQNMEAEQQRRA 320
E L + ++ +E+ T ++ L ++ +S+ LS +++LQ +Q +A
Sbjct: 2424 EREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSF-LSEKDSLLQRERFIEQEKA 2482
Query: 321 QEAQRHKEAEAERMTLKVQQLTREQQQCHKELQQAYCELSRRISEHDQCEWRCMDKTKLT 380
+ Q ++ A+ L+ +Q R+QQQ +E Q+ + + E
Sbjct: 2483 KLEQLFQDEVAKAQQLREEQ-QRQQQQMEQERQRLVASMEEARRRQHEAE---------- 2531
Query: 381 LQAIKDTEAQVDRLRQEAQKAEEALAMARLELREQTQEGEEE 422
+ ++ + ++ +L Q+ ++ EE LA LREQ Q EE+
Sbjct: 2532 -EGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2572
Score = 53.1 bits (126), Expect = 7e-07
Identities = 96/432 (22%), Positives = 162/432 (37%), Gaps = 50/432 (11%)
Query: 28 ELRARRGSQDPRRRGAGEVPADLGPLRVPGSRAASSCGLCGREPRLGRAGGFESRPAEDR 87
E+R R + R G +L LR A + E R R +D
Sbjct: 1421 EIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLR------RQVQDE 1474
Query: 88 AARAIQGAFR---QLRARRELARRREERREYLEQMETPQKEAYLAPVRREQEAARRLREQ 144
+ R Q +++A E AR ++ + LE++ +EA + E E AR+++
Sbjct: 1475 SQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVA 1534
Query: 145 EEAAQRERREELQRRRRLLDAAFDGDVGEIRAVLKE----VEQLLTREGVGHDEAGEARR 200
E AQR ELQ +R A+F ++ L+E V QL + EA R
Sbjct: 1535 LETAQRSAEAELQSKR----ASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAER 1590
Query: 201 LQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGH 260
+ AE E +EA L ++L+AE A S
Sbjct: 1591 AREE---AERELERWQLKANEA------LRLRLQAEEVAQQKS----------------- 1624
Query: 261 LAAVEVLLKLGADPRVYAEDGSTPERVASLDTVVSVLRSWDLSLTEAMLQNMEAEQQRRA 320
LA E + R G E+ + L E Q A +Q
Sbjct: 1625 LAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELI 1684
Query: 321 QEAQRHKEAEAERMTL--KVQQLTREQQQCHKELQQAYCELSRRISEHD---QCEWRCMD 375
+ ++ E +R L ++ +L RE ++ Q+ EL++ +E + + R +
Sbjct: 1685 RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE 1744
Query: 376 KTKLTLQAIKD-TEAQVDRLRQEAQKAEEALAMARLELREQTQEGEEEAPGLKCQVTELH 434
+++ T + K EA+ R R+ A++A A+A E + Q Q EE+A + + +
Sbjct: 1745 ESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE-EAKRQRQLAEEDAARQRAEAERVL 1803
Query: 435 DVLMKDVGNRIR 446
+ +G R
Sbjct: 1804 AEKLAAIGEATR 1815
Score = 50.4 bits (119), Expect = 4e-06
Identities = 81/387 (20%), Positives = 148/387 (38%), Gaps = 43/387 (11%)
Query: 80 ESRPAEDRAARAIQGAFRQLRARRELARRREERREYLEQMETPQKEAYLAPVRREQEAAR 139
+SR + A R Q A Q +AR + E+ R+ EQ + +A A +R++Q A
Sbjct: 2074 QSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADA 2133
Query: 140 RLR----------------EQEEAAQRERREELQRRRRLLDAAFD---GDVGEIRAVLKE 180
+ EQE R + EE ++ LLD + E +
Sbjct: 2134 EMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQ 2193
Query: 181 VEQLLTREGVGHDEAGEAR---RLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAEL 237
VE+ L V +E + + + R + +D+ EA Q R +
Sbjct: 2194 VEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSV 2253
Query: 238 GASPNSK-------GAFGPTPLYRAAFGGHLAAVEVLLKLGADPRVYAEDGS-TPERVAS 289
A ++ L + AV+ +L A+ + + E+
Sbjct: 2254 AAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARR 2313
Query: 290 LDTVVSVLRSWDLSLTEAMLQNMEAEQQRRAQEAQRHKEAEAERMTLKVQQLTREQQQCH 349
L + T+ + +EAE+QR Q AEAER+ L+V +++R Q +
Sbjct: 2314 LQEDKEQMAQQLAEETQGFQRTLEAERQR-----QLEMSAEAERLKLRVAEMSRAQARAE 2368
Query: 350 KELQQAYCELSRRISEHDQCEWRCMDKTKLTLQAIKDTEAQVDRLRQEAQKAEEALAMAR 409
++ Q+ + + + I E + +T+L Q ++ RQ++ E L A
Sbjct: 2369 EDAQR-FRKQAEEIGEK-------LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAI 2420
Query: 410 LELREQTQEGEEEAPGLKCQVTELHDV 436
EL + ++ ++EA L+ + E+ V
Sbjct: 2421 AELEREKEKLQQEAKLLQLKSEEMQTV 2447
Score = 40.0 bits (92), Expect = 0.006
Identities = 86/376 (22%), Positives = 139/376 (36%), Gaps = 60/376 (15%)
Query: 90 RAIQGAFRQLRARRELARRREERREYLEQMETPQKEAYLAPVRREQEAAR----RLREQE 145
R QGA LRA E + + L ++E + A L +R + EA + LR++
Sbjct: 1064 RGTQGAEEVLRAHEEQLKEAQAVPATLPELEATK--ASLKKLRAQAEAQQPTFDALRDEL 1121
Query: 146 EAAQRERREELQRRRRLLDAAFDGDVGEIRAVLKEVEQLLTREGVGH---DEAGEARRLQ 202
AQ E E LQ+R D + + +L+ + +L + V ++ G R
Sbjct: 1122 RGAQ-EVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYY 1180
Query: 203 RRVAL---AECEDSYGNTPLSEAA--AGGQPLAIQLRAELGASPN--------------S 243
R A A +D+ +A A Q + QLR E +
Sbjct: 1181 RESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFA 1240
Query: 244 KGAFGPTPLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVASLDTVVS---VLRSW 300
K Y + A +E + P+V + S + L T S L S
Sbjct: 1241 KQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQ 1300
Query: 301 DLSLTEAMLQNMEAEQ----QRRAQEAQRHKEAEAERMTLKVQQLTREQQQCHKELQQAY 356
+ L+ ME E+ Q+RA+E R + AE E K +QL Q + ++
Sbjct: 1301 YIKFISETLRRMEEEERLAEQQRAEE--RERLAEVEAALEKQRQLAEAHAQAKAQAEREA 1358
Query: 357 CELSRRISEHDQCEWRCMDKTKLTLQAIKDTEAQVDRLRQEAQKAEEALAMARLELREQT 416
EL +R+ E + ++ EA VD +Q+ EE L+ Q+
Sbjct: 1359 KELQQRMQE----------------EVVRREEAAVDAQQQKRSIQEE------LQQLRQS 1396
Query: 417 QEGEEEAPGLKCQVTE 432
E E +A + + E
Sbjct: 1397 SEAEIQAKARQAEAAE 1412
Score = 32.7 bits (73), Expect = 0.94
Identities = 30/104 (28%), Positives = 46/104 (44%), Gaps = 20/104 (19%)
Query: 109 REERREYLEQMETPQKEAYLAPVRREQEAARRLREQEEAAQRERREELQRRRRLLDAAFD 168
REE++ +QME ++ V +EA RR E EE +R ++EELQ
Sbjct: 2499 REEQQRQQQQMEQERQRL----VASMEEARRRQHEAEEGVRR-KQEELQ----------- 2542
Query: 169 GDVGEIRAVLKEVEQLLTREGVGHDEAGEARRLQRRVALAECED 212
++ ++ E+LL E E + Q R ALA E+
Sbjct: 2543 ----QLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEE 2582
Score = 32.0 bits (71), Expect = 1.6
Identities = 20/68 (29%), Positives = 31/68 (45%)
Query: 87 RAARAIQGAFRQLRARRELARRREERREYLEQMETPQKEAYLAPVRREQEAARRLREQEE 146
R +++ A R+ E RR++E + LEQ Q+E +R +E + L EQ
Sbjct: 2515 RLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHR 2574
Query: 147 AAQRERRE 154
AA E
Sbjct: 2575 AALAHSEE 2582
Score = 31.6 bits (70), Expect = 2.1
Identities = 40/151 (26%), Positives = 62/151 (41%), Gaps = 25/151 (16%)
Query: 289 SLDTVVSVLRSWDLSLTEAMLQNMEAEQQRRAQEA-QRHKEA------------EAERMT 335
SL V ++RSW L A + ++ E+QR+A + + H +A +R+
Sbjct: 866 SLRRDVQLIRSWSL----ATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLM 921
Query: 336 LKVQQLTREQQQCHKELQQAYCELSRRISEHDQCEWRCMDKTK-LTLQAIKDTEAQVDRL 394
+ RE C QQ L + E +C+ RC+ + K + LQ V RL
Sbjct: 922 AE-----REYGSCSHHYQQLLQSLEQGAQEESRCQ-RCISELKDIRLQLEACETRTVHRL 975
Query: 395 RQEAQKAEEALAMARLELREQTQEGEEEAPG 425
R K E A A+ +Q + E E G
Sbjct: 976 RLPLDK-EPARECAQRIAEQQKAQAEVEGLG 1005
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 65.9 bits (159), Expect = 1e-10
Identities = 93/381 (24%), Positives = 166/381 (43%), Gaps = 48/381 (12%)
Query: 80 ESRPAEDRAARAIQ---GAFRQL-------RARRELARRREERREYLEQMETPQKEAYLA 129
ESR +++ + ++ G FR+L RA E A+R+ + E + + E LA
Sbjct: 1914 ESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLA 1973
Query: 130 PVRREQEAARRLREQEEAAQRERREELQRRRRLL-DAAFD------------GDVGEIRA 176
A RL+ + E A +E+ E +R RRL D AF D+ E A
Sbjct: 1974 EKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLA 2033
Query: 177 VLKEV--EQLLTREGVGHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLR 234
L++ +L ++G+ D + R+++ + + +AAAG L ++L
Sbjct: 2034 QLRKASDSELERQKGLVEDTLRQRRQVEEEILALKAS-------FEKAAAGKAELELELG 2086
Query: 235 AELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADPRVY----AEDGSTPERVASL 290
+ ++ + L AA LAA E + A+ RV AE+ + +R A+L
Sbjct: 2087 RIRSNAEDTLRSKEQAEL-EAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL 2145
Query: 291 DTVVSVLRSWDLS--LTEAMLQNMEAEQQRRAQEAQRHKEAEAERMTLKVQQLTREQQQC 348
+ V + + + L E Q + Q + AQ+ +AE + VQQ +E QQ
Sbjct: 2146 EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT 2205
Query: 349 HKELQ------QAYCELSRRISEHDQCEWRCMDKTKLTLQAIKDTEAQVDRLRQEAQKAE 402
++ Q + E +RR +E + E + + Q+ + E + +RL+Q A++
Sbjct: 2206 LQQEQSVLDQLRGEAEAARRAAE--EAEEARVQAEREAAQSRRQVE-EAERLKQSAEEQA 2262
Query: 403 EALAMARLELREQTQEGEEEA 423
+A A A+ + +E E+EA
Sbjct: 2263 QARAQAQAAAEKLRKEAEQEA 2283
Score = 62.4 bits (150), Expect = 1e-09
Identities = 84/346 (24%), Positives = 139/346 (40%), Gaps = 45/346 (13%)
Query: 121 TPQKEAYLAPVRREQEAARRLREQEEAAQRERREE----LQRRRRLLDAAFDGDVGEIRA 176
T Q +++ R E RL EQ+ A +RER E L+++R+L +A R
Sbjct: 1467 TSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAERE 1526
Query: 177 VLKEVEQLLTREGVGHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQ---- 232
KE++Q + E V +EA + Q+R E + ++ A Q A +
Sbjct: 1527 A-KELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRL 1585
Query: 233 --------LRAELGASPNSK-GAFGPTPLYRAAFGGHLAAVEVLLKLGADPRVYAEDGST 283
+R +L A+ + GA G RA A + R +D S
Sbjct: 1586 RIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQ 1645
Query: 284 PERVASLDTVVSVLRSWDL---------SLTEAMLQNMEAEQQRRAQEAQR--------- 325
+R A ++ V + +L E LQ EAE++ R E +R
Sbjct: 1646 RKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALE 1705
Query: 326 --HKEAEAERMTL------KVQQLTREQQQCHKELQQAYCELSRRISEHDQCEWRCMDKT 377
+ AEAE + K QL R Q+ H + Q E RR + + E R ++
Sbjct: 1706 TAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAE-RAREEA 1764
Query: 378 KLTLQAIKDTEAQVDRLRQEAQKAEEALAMARLELREQTQEGEEEA 423
+ L+ + + RLR +A++ + ++A+ E +Q +E E EA
Sbjct: 1765 ERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREA 1810
Score = 60.8 bits (146), Expect = 3e-09
Identities = 100/457 (21%), Positives = 186/457 (40%), Gaps = 74/457 (16%)
Query: 28 ELRARRGSQDPRRRGAGEVPADLGPLRVPGS---RAASSCGL-CGREPRLGRAGGFESRP 83
E+ A + S + G E+ +LG +R R+ L R+ +L R
Sbjct: 2063 EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRRE 2122
Query: 84 AEDRAARAIQGAFRQLRARRELARRREERREYLEQMETPQKEAYLAPVRREQEAARRLRE 143
AE+R ++ L A E AR+R+ E +E+++ +EA R EQE+AR+L+
Sbjct: 2123 AEERVQKS-------LAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQL 2175
Query: 144 QEEAAQR--------------ERREELQRRRRLLDAAFDGDVGEIRAVLKEVEQLLTREG 189
+EAAQ+ ++ +ELQ+ + + D GE A + E+
Sbjct: 2176 AQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARV 2235
Query: 190 VGHDEAGEARR-LQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFG 248
EA ++RR ++ L + + ++A A Q A +LR E +
Sbjct: 2236 QAEREAAQSRRQVEEAERLKQSAEEQ-----AQARAQAQAAAEKLRKEAEQEAARRAQAE 2290
Query: 249 PTPLYR-----AAFGGHLAAVEVLLKLGADP-------RVYAEDGSTPERVASLDTVVSV 296
L + A H E L+ A R+ E+ T + LD +
Sbjct: 2291 QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE--TDHQKNLLDEELQR 2348
Query: 297 LRSWDLSLTEAMLQNMEAEQQRRAQEAQRHK--------EAEAERMTLK----VQQLTRE 344
L++ TEA Q + E++ + Q + EAE + L+ Q+ +E
Sbjct: 2349 LKA---EATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQE 2405
Query: 345 QQQCHKELQQAYCELS---------RRISEHDQCEWRCMDKTKL--TLQAIKDT---EAQ 390
+ + K++ + LS R+++E D + R + + L +QA+++ +A+
Sbjct: 2406 EAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAE 2465
Query: 391 VDRLRQEAQKAEEALAMARLELREQTQEGEEEAPGLK 427
+ L+Q+ + A+E + + + Q+ EE G +
Sbjct: 2466 AELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQ 2502
Score = 56.2 bits (134), Expect = 8e-08
Identities = 80/342 (23%), Positives = 147/342 (42%), Gaps = 26/342 (7%)
Query: 84 AEDRAARAIQGAFRQLRARRELARRR-EERREYLEQMETPQKEAYLAPVRRE--QEAARR 140
A AAR Q A L +R LA + +E+ + +++ + EA L ++E QE ARR
Sbjct: 2423 AAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARR 2482
Query: 141 LREQEEAAQRERREELQRRRRLLDAAFDGDVGEIRAVLKEVEQLLTREGVGHDEAGEARR 200
L+E +E ++ EE Q +R L+A + E+ A E E+L R V +AR
Sbjct: 2483 LQEDKEQMAQQLAEETQGFQRTLEAERQRQL-EMSA---EAERLKLR--VAEMSRAQARA 2536
Query: 201 LQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGH 260
+ + + G A + + + E+ + A R A
Sbjct: 2537 EEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDA----ERLREAIAEL 2592
Query: 261 LAAVEVLLKLGADPRVYAEDGSTPERVASLDTVVSVLRSWDLSLTEAMLQNMEAEQQRRA 320
E L + ++ +E+ T ++ L ++ +S+ LS +++LQ +Q +A
Sbjct: 2593 EREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSF-LSEKDSLLQRERFIEQEKA 2651
Query: 321 QEAQRHKEAEAERMTLKVQQLTREQQQCHKELQQAYCELSRRISEHDQCEWRCMDKTKLT 380
+ Q ++ A+ L+ +Q R+QQQ +E Q+ + + E
Sbjct: 2652 KLEQLFQDEVAKAQQLREEQ-QRQQQQMEQERQRLVASMEEARRRQHEAE---------- 2700
Query: 381 LQAIKDTEAQVDRLRQEAQKAEEALAMARLELREQTQEGEEE 422
+ ++ + ++ +L Q+ ++ EE LA LREQ Q EE+
Sbjct: 2701 -EGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2741
Score = 53.1 bits (126), Expect = 7e-07
Identities = 96/432 (22%), Positives = 162/432 (37%), Gaps = 50/432 (11%)
Query: 28 ELRARRGSQDPRRRGAGEVPADLGPLRVPGSRAASSCGLCGREPRLGRAGGFESRPAEDR 87
E+R R + R G +L LR A + E R R +D
Sbjct: 1590 EIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLR------RQVQDE 1643
Query: 88 AARAIQGAFR---QLRARRELARRREERREYLEQMETPQKEAYLAPVRREQEAARRLREQ 144
+ R Q +++A E AR ++ + LE++ +EA + E E AR+++
Sbjct: 1644 SQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVA 1703
Query: 145 EEAAQRERREELQRRRRLLDAAFDGDVGEIRAVLKE----VEQLLTREGVGHDEAGEARR 200
E AQR ELQ +R A+F ++ L+E V QL + EA R
Sbjct: 1704 LETAQRSAEAELQSKR----ASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAER 1759
Query: 201 LQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGH 260
+ AE E +EA L ++L+AE A S
Sbjct: 1760 AREE---AERELERWQLKANEA------LRLRLQAEEVAQQKS----------------- 1793
Query: 261 LAAVEVLLKLGADPRVYAEDGSTPERVASLDTVVSVLRSWDLSLTEAMLQNMEAEQQRRA 320
LA E + R G E+ + L E Q A +Q
Sbjct: 1794 LAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELI 1853
Query: 321 QEAQRHKEAEAERMTL--KVQQLTREQQQCHKELQQAYCELSRRISEHD---QCEWRCMD 375
+ ++ E +R L ++ +L RE ++ Q+ EL++ +E + + R +
Sbjct: 1854 RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE 1913
Query: 376 KTKLTLQAIKD-TEAQVDRLRQEAQKAEEALAMARLELREQTQEGEEEAPGLKCQVTELH 434
+++ T + K EA+ R R+ A++A A+A E + Q Q EE+A + + +
Sbjct: 1914 ESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE-EAKRQRQLAEEDAARQRAEAERVL 1972
Query: 435 DVLMKDVGNRIR 446
+ +G R
Sbjct: 1973 AEKLAAIGEATR 1984
Score = 50.4 bits (119), Expect = 4e-06
Identities = 81/387 (20%), Positives = 148/387 (38%), Gaps = 43/387 (11%)
Query: 80 ESRPAEDRAARAIQGAFRQLRARRELARRREERREYLEQMETPQKEAYLAPVRREQEAAR 139
+SR + A R Q A Q +AR + E+ R+ EQ + +A A +R++Q A
Sbjct: 2243 QSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADA 2302
Query: 140 RLR----------------EQEEAAQRERREELQRRRRLLDAAFD---GDVGEIRAVLKE 180
+ EQE R + EE ++ LLD + E +
Sbjct: 2303 EMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQ 2362
Query: 181 VEQLLTREGVGHDEAGEAR---RLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAEL 237
VE+ L V +E + + + R + +D+ EA Q R +
Sbjct: 2363 VEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSV 2422
Query: 238 GASPNSK-------GAFGPTPLYRAAFGGHLAAVEVLLKLGADPRVYAEDGS-TPERVAS 289
A ++ L + AV+ +L A+ + + E+
Sbjct: 2423 AAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARR 2482
Query: 290 LDTVVSVLRSWDLSLTEAMLQNMEAEQQRRAQEAQRHKEAEAERMTLKVQQLTREQQQCH 349
L + T+ + +EAE+QR Q AEAER+ L+V +++R Q +
Sbjct: 2483 LQEDKEQMAQQLAEETQGFQRTLEAERQR-----QLEMSAEAERLKLRVAEMSRAQARAE 2537
Query: 350 KELQQAYCELSRRISEHDQCEWRCMDKTKLTLQAIKDTEAQVDRLRQEAQKAEEALAMAR 409
++ Q+ + + + I E + +T+L Q ++ RQ++ E L A
Sbjct: 2538 EDAQR-FRKQAEEIGEK-------LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAI 2589
Query: 410 LELREQTQEGEEEAPGLKCQVTELHDV 436
EL + ++ ++EA L+ + E+ V
Sbjct: 2590 AELEREKEKLQQEAKLLQLKSEEMQTV 2616
Score = 40.0 bits (92), Expect = 0.006
Identities = 86/376 (22%), Positives = 139/376 (36%), Gaps = 60/376 (15%)
Query: 90 RAIQGAFRQLRARRELARRREERREYLEQMETPQKEAYLAPVRREQEAAR----RLREQE 145
R QGA LRA E + + L ++E + A L +R + EA + LR++
Sbjct: 1233 RGTQGAEEVLRAHEEQLKEAQAVPATLPELEATK--ASLKKLRAQAEAQQPTFDALRDEL 1290
Query: 146 EAAQRERREELQRRRRLLDAAFDGDVGEIRAVLKEVEQLLTREGVGH---DEAGEARRLQ 202
AQ E E LQ+R D + + +L+ + +L + V ++ G R
Sbjct: 1291 RGAQ-EVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYY 1349
Query: 203 RRVAL---AECEDSYGNTPLSEAA--AGGQPLAIQLRAELGASPN--------------S 243
R A A +D+ +A A Q + QLR E +
Sbjct: 1350 RESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFA 1409
Query: 244 KGAFGPTPLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVASLDTVVS---VLRSW 300
K Y + A +E + P+V + S + L T S L S
Sbjct: 1410 KQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQ 1469
Query: 301 DLSLTEAMLQNMEAEQ----QRRAQEAQRHKEAEAERMTLKVQQLTREQQQCHKELQQAY 356
+ L+ ME E+ Q+RA+E R + AE E K +QL Q + ++
Sbjct: 1470 YIKFISETLRRMEEEERLAEQQRAEE--RERLAEVEAALEKQRQLAEAHAQAKAQAEREA 1527
Query: 357 CELSRRISEHDQCEWRCMDKTKLTLQAIKDTEAQVDRLRQEAQKAEEALAMARLELREQT 416
EL +R+ E + ++ EA VD +Q+ EE L+ Q+
Sbjct: 1528 KELQQRMQE----------------EVVRREEAAVDAQQQKRSIQEE------LQQLRQS 1565
Query: 417 QEGEEEAPGLKCQVTE 432
E E +A + + E
Sbjct: 1566 SEAEIQAKARQAEAAE 1581
Score = 32.7 bits (73), Expect = 0.94
Identities = 30/104 (28%), Positives = 46/104 (44%), Gaps = 20/104 (19%)
Query: 109 REERREYLEQMETPQKEAYLAPVRREQEAARRLREQEEAAQRERREELQRRRRLLDAAFD 168
REE++ +QME ++ V +EA RR E EE +R ++EELQ
Sbjct: 2668 REEQQRQQQQMEQERQRL----VASMEEARRRQHEAEEGVRR-KQEELQ----------- 2711
Query: 169 GDVGEIRAVLKEVEQLLTREGVGHDEAGEARRLQRRVALAECED 212
++ ++ E+LL E E + Q R ALA E+
Sbjct: 2712 ----QLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEE 2751
Score = 32.0 bits (71), Expect = 1.6
Identities = 20/68 (29%), Positives = 31/68 (45%)
Query: 87 RAARAIQGAFRQLRARRELARRREERREYLEQMETPQKEAYLAPVRREQEAARRLREQEE 146
R +++ A R+ E RR++E + LEQ Q+E +R +E + L EQ
Sbjct: 2684 RLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHR 2743
Query: 147 AAQRERRE 154
AA E
Sbjct: 2744 AALAHSEE 2751
Score = 31.6 bits (70), Expect = 2.1
Identities = 40/151 (26%), Positives = 62/151 (41%), Gaps = 25/151 (16%)
Query: 289 SLDTVVSVLRSWDLSLTEAMLQNMEAEQQRRAQEA-QRHKEA------------EAERMT 335
SL V ++RSW L A + ++ E+QR+A + + H +A +R+
Sbjct: 1035 SLRRDVQLIRSWSL----ATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLM 1090
Query: 336 LKVQQLTREQQQCHKELQQAYCELSRRISEHDQCEWRCMDKTK-LTLQAIKDTEAQVDRL 394
+ RE C QQ L + E +C+ RC+ + K + LQ V RL
Sbjct: 1091 AE-----REYGSCSHHYQQLLQSLEQGAQEESRCQ-RCISELKDIRLQLEACETRTVHRL 1144
Query: 395 RQEAQKAEEALAMARLELREQTQEGEEEAPG 425
R K E A A+ +Q + E E G
Sbjct: 1145 RLPLDK-EPARECAQRIAEQQKAQAEVEGLG 1174
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 65.9 bits (159), Expect = 1e-10
Identities = 93/381 (24%), Positives = 166/381 (43%), Gaps = 48/381 (12%)
Query: 80 ESRPAEDRAARAIQ---GAFRQL-------RARRELARRREERREYLEQMETPQKEAYLA 129
ESR +++ + ++ G FR+L RA E A+R+ + E + + E LA
Sbjct: 1755 ESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLA 1814
Query: 130 PVRREQEAARRLREQEEAAQRERREELQRRRRLL-DAAFD------------GDVGEIRA 176
A RL+ + E A +E+ E +R RRL D AF D+ E A
Sbjct: 1815 EKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLA 1874
Query: 177 VLKEV--EQLLTREGVGHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLR 234
L++ +L ++G+ D + R+++ + + +AAAG L ++L
Sbjct: 1875 QLRKASDSELERQKGLVEDTLRQRRQVEEEILALKAS-------FEKAAAGKAELELELG 1927
Query: 235 AELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADPRVY----AEDGSTPERVASL 290
+ ++ + L AA LAA E + A+ RV AE+ + +R A+L
Sbjct: 1928 RIRSNAEDTLRSKEQAEL-EAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL 1986
Query: 291 DTVVSVLRSWDLS--LTEAMLQNMEAEQQRRAQEAQRHKEAEAERMTLKVQQLTREQQQC 348
+ V + + + L E Q + Q + AQ+ +AE + VQQ +E QQ
Sbjct: 1987 EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT 2046
Query: 349 HKELQ------QAYCELSRRISEHDQCEWRCMDKTKLTLQAIKDTEAQVDRLRQEAQKAE 402
++ Q + E +RR +E + E + + Q+ + E + +RL+Q A++
Sbjct: 2047 LQQEQSVLDQLRGEAEAARRAAE--EAEEARVQAEREAAQSRRQVE-EAERLKQSAEEQA 2103
Query: 403 EALAMARLELREQTQEGEEEA 423
+A A A+ + +E E+EA
Sbjct: 2104 QARAQAQAAAEKLRKEAEQEA 2124
Score = 62.4 bits (150), Expect = 1e-09
Identities = 84/346 (24%), Positives = 139/346 (40%), Gaps = 45/346 (13%)
Query: 121 TPQKEAYLAPVRREQEAARRLREQEEAAQRERREE----LQRRRRLLDAAFDGDVGEIRA 176
T Q +++ R E RL EQ+ A +RER E L+++R+L +A R
Sbjct: 1308 TSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAERE 1367
Query: 177 VLKEVEQLLTREGVGHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQ---- 232
KE++Q + E V +EA + Q+R E + ++ A Q A +
Sbjct: 1368 A-KELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRL 1426
Query: 233 --------LRAELGASPNSK-GAFGPTPLYRAAFGGHLAAVEVLLKLGADPRVYAEDGST 283
+R +L A+ + GA G RA A + R +D S
Sbjct: 1427 RIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQ 1486
Query: 284 PERVASLDTVVSVLRSWDL---------SLTEAMLQNMEAEQQRRAQEAQR--------- 325
+R A ++ V + +L E LQ EAE++ R E +R
Sbjct: 1487 RKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALE 1546
Query: 326 --HKEAEAERMTL------KVQQLTREQQQCHKELQQAYCELSRRISEHDQCEWRCMDKT 377
+ AEAE + K QL R Q+ H + Q E RR + + E R ++
Sbjct: 1547 TAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAE-RAREEA 1605
Query: 378 KLTLQAIKDTEAQVDRLRQEAQKAEEALAMARLELREQTQEGEEEA 423
+ L+ + + RLR +A++ + ++A+ E +Q +E E EA
Sbjct: 1606 ERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREA 1651
Score = 60.8 bits (146), Expect = 3e-09
Identities = 100/457 (21%), Positives = 186/457 (40%), Gaps = 74/457 (16%)
Query: 28 ELRARRGSQDPRRRGAGEVPADLGPLRVPGS---RAASSCGL-CGREPRLGRAGGFESRP 83
E+ A + S + G E+ +LG +R R+ L R+ +L R
Sbjct: 1904 EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRRE 1963
Query: 84 AEDRAARAIQGAFRQLRARRELARRREERREYLEQMETPQKEAYLAPVRREQEAARRLRE 143
AE+R ++ L A E AR+R+ E +E+++ +EA R EQE+AR+L+
Sbjct: 1964 AEERVQKS-------LAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQL 2016
Query: 144 QEEAAQR--------------ERREELQRRRRLLDAAFDGDVGEIRAVLKEVEQLLTREG 189
+EAAQ+ ++ +ELQ+ + + D GE A + E+
Sbjct: 2017 AQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARV 2076
Query: 190 VGHDEAGEARR-LQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFG 248
EA ++RR ++ L + + ++A A Q A +LR E +
Sbjct: 2077 QAEREAAQSRRQVEEAERLKQSAEEQ-----AQARAQAQAAAEKLRKEAEQEAARRAQAE 2131
Query: 249 PTPLYR-----AAFGGHLAAVEVLLKLGADP-------RVYAEDGSTPERVASLDTVVSV 296
L + A H E L+ A R+ E+ T + LD +
Sbjct: 2132 QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE--TDHQKNLLDEELQR 2189
Query: 297 LRSWDLSLTEAMLQNMEAEQQRRAQEAQRHK--------EAEAERMTLK----VQQLTRE 344
L++ TEA Q + E++ + Q + EAE + L+ Q+ +E
Sbjct: 2190 LKA---EATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQE 2246
Query: 345 QQQCHKELQQAYCELS---------RRISEHDQCEWRCMDKTKL--TLQAIKDT---EAQ 390
+ + K++ + LS R+++E D + R + + L +QA+++ +A+
Sbjct: 2247 EAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAE 2306
Query: 391 VDRLRQEAQKAEEALAMARLELREQTQEGEEEAPGLK 427
+ L+Q+ + A+E + + + Q+ EE G +
Sbjct: 2307 AELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQ 2343
Score = 56.2 bits (134), Expect = 8e-08
Identities = 80/342 (23%), Positives = 147/342 (42%), Gaps = 26/342 (7%)
Query: 84 AEDRAARAIQGAFRQLRARRELARRR-EERREYLEQMETPQKEAYLAPVRRE--QEAARR 140
A AAR Q A L +R LA + +E+ + +++ + EA L ++E QE ARR
Sbjct: 2264 AAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARR 2323
Query: 141 LREQEEAAQRERREELQRRRRLLDAAFDGDVGEIRAVLKEVEQLLTREGVGHDEAGEARR 200
L+E +E ++ EE Q +R L+A + E+ A E E+L R V +AR
Sbjct: 2324 LQEDKEQMAQQLAEETQGFQRTLEAERQRQL-EMSA---EAERLKLR--VAEMSRAQARA 2377
Query: 201 LQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGH 260
+ + + G A + + + E+ + A R A
Sbjct: 2378 EEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDA----ERLREAIAEL 2433
Query: 261 LAAVEVLLKLGADPRVYAEDGSTPERVASLDTVVSVLRSWDLSLTEAMLQNMEAEQQRRA 320
E L + ++ +E+ T ++ L ++ +S+ LS +++LQ +Q +A
Sbjct: 2434 EREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSF-LSEKDSLLQRERFIEQEKA 2492
Query: 321 QEAQRHKEAEAERMTLKVQQLTREQQQCHKELQQAYCELSRRISEHDQCEWRCMDKTKLT 380
+ Q ++ A+ L+ +Q R+QQQ +E Q+ + + E
Sbjct: 2493 KLEQLFQDEVAKAQQLREEQ-QRQQQQMEQERQRLVASMEEARRRQHEAE---------- 2541
Query: 381 LQAIKDTEAQVDRLRQEAQKAEEALAMARLELREQTQEGEEE 422
+ ++ + ++ +L Q+ ++ EE LA LREQ Q EE+
Sbjct: 2542 -EGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2582
Score = 53.1 bits (126), Expect = 7e-07
Identities = 96/432 (22%), Positives = 162/432 (37%), Gaps = 50/432 (11%)
Query: 28 ELRARRGSQDPRRRGAGEVPADLGPLRVPGSRAASSCGLCGREPRLGRAGGFESRPAEDR 87
E+R R + R G +L LR A + E R R +D
Sbjct: 1431 EIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLR------RQVQDE 1484
Query: 88 AARAIQGAFR---QLRARRELARRREERREYLEQMETPQKEAYLAPVRREQEAARRLREQ 144
+ R Q +++A E AR ++ + LE++ +EA + E E AR+++
Sbjct: 1485 SQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVA 1544
Query: 145 EEAAQRERREELQRRRRLLDAAFDGDVGEIRAVLKE----VEQLLTREGVGHDEAGEARR 200
E AQR ELQ +R A+F ++ L+E V QL + EA R
Sbjct: 1545 LETAQRSAEAELQSKR----ASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAER 1600
Query: 201 LQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGH 260
+ AE E +EA L ++L+AE A S
Sbjct: 1601 AREE---AERELERWQLKANEA------LRLRLQAEEVAQQKS----------------- 1634
Query: 261 LAAVEVLLKLGADPRVYAEDGSTPERVASLDTVVSVLRSWDLSLTEAMLQNMEAEQQRRA 320
LA E + R G E+ + L E Q A +Q
Sbjct: 1635 LAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELI 1694
Query: 321 QEAQRHKEAEAERMTL--KVQQLTREQQQCHKELQQAYCELSRRISEHD---QCEWRCMD 375
+ ++ E +R L ++ +L RE ++ Q+ EL++ +E + + R +
Sbjct: 1695 RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE 1754
Query: 376 KTKLTLQAIKD-TEAQVDRLRQEAQKAEEALAMARLELREQTQEGEEEAPGLKCQVTELH 434
+++ T + K EA+ R R+ A++A A+A E + Q Q EE+A + + +
Sbjct: 1755 ESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE-EAKRQRQLAEEDAARQRAEAERVL 1813
Query: 435 DVLMKDVGNRIR 446
+ +G R
Sbjct: 1814 AEKLAAIGEATR 1825
Score = 50.4 bits (119), Expect = 4e-06
Identities = 81/387 (20%), Positives = 148/387 (38%), Gaps = 43/387 (11%)
Query: 80 ESRPAEDRAARAIQGAFRQLRARRELARRREERREYLEQMETPQKEAYLAPVRREQEAAR 139
+SR + A R Q A Q +AR + E+ R+ EQ + +A A +R++Q A
Sbjct: 2084 QSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADA 2143
Query: 140 RLR----------------EQEEAAQRERREELQRRRRLLDAAFD---GDVGEIRAVLKE 180
+ EQE R + EE ++ LLD + E +
Sbjct: 2144 EMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQ 2203
Query: 181 VEQLLTREGVGHDEAGEAR---RLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAEL 237
VE+ L V +E + + + R + +D+ EA Q R +
Sbjct: 2204 VEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSV 2263
Query: 238 GASPNSK-------GAFGPTPLYRAAFGGHLAAVEVLLKLGADPRVYAEDGS-TPERVAS 289
A ++ L + AV+ +L A+ + + E+
Sbjct: 2264 AAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARR 2323
Query: 290 LDTVVSVLRSWDLSLTEAMLQNMEAEQQRRAQEAQRHKEAEAERMTLKVQQLTREQQQCH 349
L + T+ + +EAE+QR Q AEAER+ L+V +++R Q +
Sbjct: 2324 LQEDKEQMAQQLAEETQGFQRTLEAERQR-----QLEMSAEAERLKLRVAEMSRAQARAE 2378
Query: 350 KELQQAYCELSRRISEHDQCEWRCMDKTKLTLQAIKDTEAQVDRLRQEAQKAEEALAMAR 409
++ Q+ + + + I E + +T+L Q ++ RQ++ E L A
Sbjct: 2379 EDAQR-FRKQAEEIGEK-------LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAI 2430
Query: 410 LELREQTQEGEEEAPGLKCQVTELHDV 436
EL + ++ ++EA L+ + E+ V
Sbjct: 2431 AELEREKEKLQQEAKLLQLKSEEMQTV 2457
Score = 40.0 bits (92), Expect = 0.006
Identities = 86/376 (22%), Positives = 139/376 (36%), Gaps = 60/376 (15%)
Query: 90 RAIQGAFRQLRARRELARRREERREYLEQMETPQKEAYLAPVRREQEAAR----RLREQE 145
R QGA LRA E + + L ++E + A L +R + EA + LR++
Sbjct: 1074 RGTQGAEEVLRAHEEQLKEAQAVPATLPELEATK--ASLKKLRAQAEAQQPTFDALRDEL 1131
Query: 146 EAAQRERREELQRRRRLLDAAFDGDVGEIRAVLKEVEQLLTREGVGH---DEAGEARRLQ 202
AQ E E LQ+R D + + +L+ + +L + V ++ G R
Sbjct: 1132 RGAQ-EVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYY 1190
Query: 203 RRVAL---AECEDSYGNTPLSEAA--AGGQPLAIQLRAELGASPN--------------S 243
R A A +D+ +A A Q + QLR E +
Sbjct: 1191 RESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFA 1250
Query: 244 KGAFGPTPLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVASLDTVVS---VLRSW 300
K Y + A +E + P+V + S + L T S L S
Sbjct: 1251 KQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQ 1310
Query: 301 DLSLTEAMLQNMEAEQ----QRRAQEAQRHKEAEAERMTLKVQQLTREQQQCHKELQQAY 356
+ L+ ME E+ Q+RA+E R + AE E K +QL Q + ++
Sbjct: 1311 YIKFISETLRRMEEEERLAEQQRAEE--RERLAEVEAALEKQRQLAEAHAQAKAQAEREA 1368
Query: 357 CELSRRISEHDQCEWRCMDKTKLTLQAIKDTEAQVDRLRQEAQKAEEALAMARLELREQT 416
EL +R+ E + ++ EA VD +Q+ EE L+ Q+
Sbjct: 1369 KELQQRMQE----------------EVVRREEAAVDAQQQKRSIQEE------LQQLRQS 1406
Query: 417 QEGEEEAPGLKCQVTE 432
E E +A + + E
Sbjct: 1407 SEAEIQAKARQAEAAE 1422
Score = 32.7 bits (73), Expect = 0.94
Identities = 30/104 (28%), Positives = 46/104 (44%), Gaps = 20/104 (19%)
Query: 109 REERREYLEQMETPQKEAYLAPVRREQEAARRLREQEEAAQRERREELQRRRRLLDAAFD 168
REE++ +QME ++ V +EA RR E EE +R ++EELQ
Sbjct: 2509 REEQQRQQQQMEQERQRL----VASMEEARRRQHEAEEGVRR-KQEELQ----------- 2552
Query: 169 GDVGEIRAVLKEVEQLLTREGVGHDEAGEARRLQRRVALAECED 212
++ ++ E+LL E E + Q R ALA E+
Sbjct: 2553 ----QLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEE 2592
Score = 32.0 bits (71), Expect = 1.6
Identities = 20/68 (29%), Positives = 31/68 (45%)
Query: 87 RAARAIQGAFRQLRARRELARRREERREYLEQMETPQKEAYLAPVRREQEAARRLREQEE 146
R +++ A R+ E RR++E + LEQ Q+E +R +E + L EQ
Sbjct: 2525 RLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHR 2584
Query: 147 AAQRERRE 154
AA E
Sbjct: 2585 AALAHSEE 2592
Score = 31.6 bits (70), Expect = 2.1
Identities = 40/151 (26%), Positives = 62/151 (41%), Gaps = 25/151 (16%)
Query: 289 SLDTVVSVLRSWDLSLTEAMLQNMEAEQQRRAQEA-QRHKEA------------EAERMT 335
SL V ++RSW L A + ++ E+QR+A + + H +A +R+
Sbjct: 876 SLRRDVQLIRSWSL----ATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLM 931
Query: 336 LKVQQLTREQQQCHKELQQAYCELSRRISEHDQCEWRCMDKTK-LTLQAIKDTEAQVDRL 394
+ RE C QQ L + E +C+ RC+ + K + LQ V RL
Sbjct: 932 AE-----REYGSCSHHYQQLLQSLEQGAQEESRCQ-RCISELKDIRLQLEACETRTVHRL 985
Query: 395 RQEAQKAEEALAMARLELREQTQEGEEEAPG 425
R K E A A+ +Q + E E G
Sbjct: 986 RLPLDK-EPARECAQRIAEQQKAQAEVEGLG 1015
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 65.9 bits (159), Expect = 1e-10
Identities = 93/381 (24%), Positives = 166/381 (43%), Gaps = 48/381 (12%)
Query: 80 ESRPAEDRAARAIQ---GAFRQL-------RARRELARRREERREYLEQMETPQKEAYLA 129
ESR +++ + ++ G FR+L RA E A+R+ + E + + E LA
Sbjct: 1763 ESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLA 1822
Query: 130 PVRREQEAARRLREQEEAAQRERREELQRRRRLL-DAAFD------------GDVGEIRA 176
A RL+ + E A +E+ E +R RRL D AF D+ E A
Sbjct: 1823 EKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLA 1882
Query: 177 VLKEV--EQLLTREGVGHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLR 234
L++ +L ++G+ D + R+++ + + +AAAG L ++L
Sbjct: 1883 QLRKASDSELERQKGLVEDTLRQRRQVEEEILALKAS-------FEKAAAGKAELELELG 1935
Query: 235 AELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADPRVY----AEDGSTPERVASL 290
+ ++ + L AA LAA E + A+ RV AE+ + +R A+L
Sbjct: 1936 RIRSNAEDTLRSKEQAEL-EAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL 1994
Query: 291 DTVVSVLRSWDLS--LTEAMLQNMEAEQQRRAQEAQRHKEAEAERMTLKVQQLTREQQQC 348
+ V + + + L E Q + Q + AQ+ +AE + VQQ +E QQ
Sbjct: 1995 EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT 2054
Query: 349 HKELQ------QAYCELSRRISEHDQCEWRCMDKTKLTLQAIKDTEAQVDRLRQEAQKAE 402
++ Q + E +RR +E + E + + Q+ + E + +RL+Q A++
Sbjct: 2055 LQQEQSVLDQLRGEAEAARRAAE--EAEEARVQAEREAAQSRRQVE-EAERLKQSAEEQA 2111
Query: 403 EALAMARLELREQTQEGEEEA 423
+A A A+ + +E E+EA
Sbjct: 2112 QARAQAQAAAEKLRKEAEQEA 2132
Score = 62.4 bits (150), Expect = 1e-09
Identities = 84/346 (24%), Positives = 139/346 (40%), Gaps = 45/346 (13%)
Query: 121 TPQKEAYLAPVRREQEAARRLREQEEAAQRERREE----LQRRRRLLDAAFDGDVGEIRA 176
T Q +++ R E RL EQ+ A +RER E L+++R+L +A R
Sbjct: 1316 TSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAERE 1375
Query: 177 VLKEVEQLLTREGVGHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQ---- 232
KE++Q + E V +EA + Q+R E + ++ A Q A +
Sbjct: 1376 A-KELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRL 1434
Query: 233 --------LRAELGASPNSK-GAFGPTPLYRAAFGGHLAAVEVLLKLGADPRVYAEDGST 283
+R +L A+ + GA G RA A + R +D S
Sbjct: 1435 RIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQ 1494
Query: 284 PERVASLDTVVSVLRSWDL---------SLTEAMLQNMEAEQQRRAQEAQR--------- 325
+R A ++ V + +L E LQ EAE++ R E +R
Sbjct: 1495 RKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALE 1554
Query: 326 --HKEAEAERMTL------KVQQLTREQQQCHKELQQAYCELSRRISEHDQCEWRCMDKT 377
+ AEAE + K QL R Q+ H + Q E RR + + E R ++
Sbjct: 1555 TAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAE-RAREEA 1613
Query: 378 KLTLQAIKDTEAQVDRLRQEAQKAEEALAMARLELREQTQEGEEEA 423
+ L+ + + RLR +A++ + ++A+ E +Q +E E EA
Sbjct: 1614 ERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREA 1659
Score = 60.8 bits (146), Expect = 3e-09
Identities = 100/457 (21%), Positives = 186/457 (40%), Gaps = 74/457 (16%)
Query: 28 ELRARRGSQDPRRRGAGEVPADLGPLRVPGS---RAASSCGL-CGREPRLGRAGGFESRP 83
E+ A + S + G E+ +LG +R R+ L R+ +L R
Sbjct: 1912 EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRRE 1971
Query: 84 AEDRAARAIQGAFRQLRARRELARRREERREYLEQMETPQKEAYLAPVRREQEAARRLRE 143
AE+R ++ L A E AR+R+ E +E+++ +EA R EQE+AR+L+
Sbjct: 1972 AEERVQKS-------LAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQL 2024
Query: 144 QEEAAQR--------------ERREELQRRRRLLDAAFDGDVGEIRAVLKEVEQLLTREG 189
+EAAQ+ ++ +ELQ+ + + D GE A + E+
Sbjct: 2025 AQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARV 2084
Query: 190 VGHDEAGEARR-LQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFG 248
EA ++RR ++ L + + ++A A Q A +LR E +
Sbjct: 2085 QAEREAAQSRRQVEEAERLKQSAEEQ-----AQARAQAQAAAEKLRKEAEQEAARRAQAE 2139
Query: 249 PTPLYR-----AAFGGHLAAVEVLLKLGADP-------RVYAEDGSTPERVASLDTVVSV 296
L + A H E L+ A R+ E+ T + LD +
Sbjct: 2140 QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE--TDHQKNLLDEELQR 2197
Query: 297 LRSWDLSLTEAMLQNMEAEQQRRAQEAQRHK--------EAEAERMTLK----VQQLTRE 344
L++ TEA Q + E++ + Q + EAE + L+ Q+ +E
Sbjct: 2198 LKA---EATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQE 2254
Query: 345 QQQCHKELQQAYCELS---------RRISEHDQCEWRCMDKTKL--TLQAIKDT---EAQ 390
+ + K++ + LS R+++E D + R + + L +QA+++ +A+
Sbjct: 2255 EAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAE 2314
Query: 391 VDRLRQEAQKAEEALAMARLELREQTQEGEEEAPGLK 427
+ L+Q+ + A+E + + + Q+ EE G +
Sbjct: 2315 AELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQ 2351
Score = 56.2 bits (134), Expect = 8e-08
Identities = 80/342 (23%), Positives = 147/342 (42%), Gaps = 26/342 (7%)
Query: 84 AEDRAARAIQGAFRQLRARRELARRR-EERREYLEQMETPQKEAYLAPVRRE--QEAARR 140
A AAR Q A L +R LA + +E+ + +++ + EA L ++E QE ARR
Sbjct: 2272 AAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARR 2331
Query: 141 LREQEEAAQRERREELQRRRRLLDAAFDGDVGEIRAVLKEVEQLLTREGVGHDEAGEARR 200
L+E +E ++ EE Q +R L+A + E+ A E E+L R V +AR
Sbjct: 2332 LQEDKEQMAQQLAEETQGFQRTLEAERQRQL-EMSA---EAERLKLR--VAEMSRAQARA 2385
Query: 201 LQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGH 260
+ + + G A + + + E+ + A R A
Sbjct: 2386 EEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDA----ERLREAIAEL 2441
Query: 261 LAAVEVLLKLGADPRVYAEDGSTPERVASLDTVVSVLRSWDLSLTEAMLQNMEAEQQRRA 320
E L + ++ +E+ T ++ L ++ +S+ LS +++LQ +Q +A
Sbjct: 2442 EREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSF-LSEKDSLLQRERFIEQEKA 2500
Query: 321 QEAQRHKEAEAERMTLKVQQLTREQQQCHKELQQAYCELSRRISEHDQCEWRCMDKTKLT 380
+ Q ++ A+ L+ +Q R+QQQ +E Q+ + + E
Sbjct: 2501 KLEQLFQDEVAKAQQLREEQ-QRQQQQMEQERQRLVASMEEARRRQHEAE---------- 2549
Query: 381 LQAIKDTEAQVDRLRQEAQKAEEALAMARLELREQTQEGEEE 422
+ ++ + ++ +L Q+ ++ EE LA LREQ Q EE+
Sbjct: 2550 -EGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2590
Score = 53.1 bits (126), Expect = 7e-07
Identities = 96/432 (22%), Positives = 162/432 (37%), Gaps = 50/432 (11%)
Query: 28 ELRARRGSQDPRRRGAGEVPADLGPLRVPGSRAASSCGLCGREPRLGRAGGFESRPAEDR 87
E+R R + R G +L LR A + E R R +D
Sbjct: 1439 EIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLR------RQVQDE 1492
Query: 88 AARAIQGAFR---QLRARRELARRREERREYLEQMETPQKEAYLAPVRREQEAARRLREQ 144
+ R Q +++A E AR ++ + LE++ +EA + E E AR+++
Sbjct: 1493 SQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVA 1552
Query: 145 EEAAQRERREELQRRRRLLDAAFDGDVGEIRAVLKE----VEQLLTREGVGHDEAGEARR 200
E AQR ELQ +R A+F ++ L+E V QL + EA R
Sbjct: 1553 LETAQRSAEAELQSKR----ASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAER 1608
Query: 201 LQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGH 260
+ AE E +EA L ++L+AE A S
Sbjct: 1609 AREE---AERELERWQLKANEA------LRLRLQAEEVAQQKS----------------- 1642
Query: 261 LAAVEVLLKLGADPRVYAEDGSTPERVASLDTVVSVLRSWDLSLTEAMLQNMEAEQQRRA 320
LA E + R G E+ + L E Q A +Q
Sbjct: 1643 LAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELI 1702
Query: 321 QEAQRHKEAEAERMTL--KVQQLTREQQQCHKELQQAYCELSRRISEHD---QCEWRCMD 375
+ ++ E +R L ++ +L RE ++ Q+ EL++ +E + + R +
Sbjct: 1703 RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE 1762
Query: 376 KTKLTLQAIKD-TEAQVDRLRQEAQKAEEALAMARLELREQTQEGEEEAPGLKCQVTELH 434
+++ T + K EA+ R R+ A++A A+A E + Q Q EE+A + + +
Sbjct: 1763 ESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE-EAKRQRQLAEEDAARQRAEAERVL 1821
Query: 435 DVLMKDVGNRIR 446
+ +G R
Sbjct: 1822 AEKLAAIGEATR 1833
Score = 50.4 bits (119), Expect = 4e-06
Identities = 81/387 (20%), Positives = 148/387 (38%), Gaps = 43/387 (11%)
Query: 80 ESRPAEDRAARAIQGAFRQLRARRELARRREERREYLEQMETPQKEAYLAPVRREQEAAR 139
+SR + A R Q A Q +AR + E+ R+ EQ + +A A +R++Q A
Sbjct: 2092 QSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADA 2151
Query: 140 RLR----------------EQEEAAQRERREELQRRRRLLDAAFD---GDVGEIRAVLKE 180
+ EQE R + EE ++ LLD + E +
Sbjct: 2152 EMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQ 2211
Query: 181 VEQLLTREGVGHDEAGEAR---RLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAEL 237
VE+ L V +E + + + R + +D+ EA Q R +
Sbjct: 2212 VEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSV 2271
Query: 238 GASPNSK-------GAFGPTPLYRAAFGGHLAAVEVLLKLGADPRVYAEDGS-TPERVAS 289
A ++ L + AV+ +L A+ + + E+
Sbjct: 2272 AAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARR 2331
Query: 290 LDTVVSVLRSWDLSLTEAMLQNMEAEQQRRAQEAQRHKEAEAERMTLKVQQLTREQQQCH 349
L + T+ + +EAE+QR Q AEAER+ L+V +++R Q +
Sbjct: 2332 LQEDKEQMAQQLAEETQGFQRTLEAERQR-----QLEMSAEAERLKLRVAEMSRAQARAE 2386
Query: 350 KELQQAYCELSRRISEHDQCEWRCMDKTKLTLQAIKDTEAQVDRLRQEAQKAEEALAMAR 409
++ Q+ + + + I E + +T+L Q ++ RQ++ E L A
Sbjct: 2387 EDAQR-FRKQAEEIGEK-------LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAI 2438
Query: 410 LELREQTQEGEEEAPGLKCQVTELHDV 436
EL + ++ ++EA L+ + E+ V
Sbjct: 2439 AELEREKEKLQQEAKLLQLKSEEMQTV 2465
Score = 40.0 bits (92), Expect = 0.006
Identities = 86/376 (22%), Positives = 139/376 (36%), Gaps = 60/376 (15%)
Query: 90 RAIQGAFRQLRARRELARRREERREYLEQMETPQKEAYLAPVRREQEAAR----RLREQE 145
R QGA LRA E + + L ++E + A L +R + EA + LR++
Sbjct: 1082 RGTQGAEEVLRAHEEQLKEAQAVPATLPELEATK--ASLKKLRAQAEAQQPTFDALRDEL 1139
Query: 146 EAAQRERREELQRRRRLLDAAFDGDVGEIRAVLKEVEQLLTREGVGH---DEAGEARRLQ 202
AQ E E LQ+R D + + +L+ + +L + V ++ G R
Sbjct: 1140 RGAQ-EVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYY 1198
Query: 203 RRVAL---AECEDSYGNTPLSEAA--AGGQPLAIQLRAELGASPN--------------S 243
R A A +D+ +A A Q + QLR E +
Sbjct: 1199 RESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFA 1258
Query: 244 KGAFGPTPLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVASLDTVVS---VLRSW 300
K Y + A +E + P+V + S + L T S L S
Sbjct: 1259 KQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQ 1318
Query: 301 DLSLTEAMLQNMEAEQ----QRRAQEAQRHKEAEAERMTLKVQQLTREQQQCHKELQQAY 356
+ L+ ME E+ Q+RA+E R + AE E K +QL Q + ++
Sbjct: 1319 YIKFISETLRRMEEEERLAEQQRAEE--RERLAEVEAALEKQRQLAEAHAQAKAQAEREA 1376
Query: 357 CELSRRISEHDQCEWRCMDKTKLTLQAIKDTEAQVDRLRQEAQKAEEALAMARLELREQT 416
EL +R+ E + ++ EA VD +Q+ EE L+ Q+
Sbjct: 1377 KELQQRMQE----------------EVVRREEAAVDAQQQKRSIQEE------LQQLRQS 1414
Query: 417 QEGEEEAPGLKCQVTE 432
E E +A + + E
Sbjct: 1415 SEAEIQAKARQAEAAE 1430
Score = 32.7 bits (73), Expect = 0.94
Identities = 30/104 (28%), Positives = 46/104 (44%), Gaps = 20/104 (19%)
Query: 109 REERREYLEQMETPQKEAYLAPVRREQEAARRLREQEEAAQRERREELQRRRRLLDAAFD 168
REE++ +QME ++ V +EA RR E EE +R ++EELQ
Sbjct: 2517 REEQQRQQQQMEQERQRL----VASMEEARRRQHEAEEGVRR-KQEELQ----------- 2560
Query: 169 GDVGEIRAVLKEVEQLLTREGVGHDEAGEARRLQRRVALAECED 212
++ ++ E+LL E E + Q R ALA E+
Sbjct: 2561 ----QLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEE 2600
Score = 32.0 bits (71), Expect = 1.6
Identities = 20/68 (29%), Positives = 31/68 (45%)
Query: 87 RAARAIQGAFRQLRARRELARRREERREYLEQMETPQKEAYLAPVRREQEAARRLREQEE 146
R +++ A R+ E RR++E + LEQ Q+E +R +E + L EQ
Sbjct: 2533 RLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHR 2592
Query: 147 AAQRERRE 154
AA E
Sbjct: 2593 AALAHSEE 2600
Score = 31.6 bits (70), Expect = 2.1
Identities = 40/151 (26%), Positives = 62/151 (41%), Gaps = 25/151 (16%)
Query: 289 SLDTVVSVLRSWDLSLTEAMLQNMEAEQQRRAQEA-QRHKEA------------EAERMT 335
SL V ++RSW L A + ++ E+QR+A + + H +A +R+
Sbjct: 884 SLRRDVQLIRSWSL----ATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLM 939
Query: 336 LKVQQLTREQQQCHKELQQAYCELSRRISEHDQCEWRCMDKTK-LTLQAIKDTEAQVDRL 394
+ RE C QQ L + E +C+ RC+ + K + LQ V RL
Sbjct: 940 AE-----REYGSCSHHYQQLLQSLEQGAQEESRCQ-RCISELKDIRLQLEACETRTVHRL 993
Query: 395 RQEAQKAEEALAMARLELREQTQEGEEEAPG 425
R K E A A+ +Q + E E G
Sbjct: 994 RLPLDK-EPARECAQRIAEQQKAQAEVEGLG 1023
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 65.9 bits (159), Expect = 1e-10
Identities = 93/381 (24%), Positives = 166/381 (43%), Gaps = 48/381 (12%)
Query: 80 ESRPAEDRAARAIQ---GAFRQL-------RARRELARRREERREYLEQMETPQKEAYLA 129
ESR +++ + ++ G FR+L RA E A+R+ + E + + E LA
Sbjct: 1804 ESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLA 1863
Query: 130 PVRREQEAARRLREQEEAAQRERREELQRRRRLL-DAAFD------------GDVGEIRA 176
A RL+ + E A +E+ E +R RRL D AF D+ E A
Sbjct: 1864 EKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLA 1923
Query: 177 VLKEV--EQLLTREGVGHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLR 234
L++ +L ++G+ D + R+++ + + +AAAG L ++L
Sbjct: 1924 QLRKASDSELERQKGLVEDTLRQRRQVEEEILALKAS-------FEKAAAGKAELELELG 1976
Query: 235 AELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADPRVY----AEDGSTPERVASL 290
+ ++ + L AA LAA E + A+ RV AE+ + +R A+L
Sbjct: 1977 RIRSNAEDTLRSKEQAEL-EAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL 2035
Query: 291 DTVVSVLRSWDLS--LTEAMLQNMEAEQQRRAQEAQRHKEAEAERMTLKVQQLTREQQQC 348
+ V + + + L E Q + Q + AQ+ +AE + VQQ +E QQ
Sbjct: 2036 EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT 2095
Query: 349 HKELQ------QAYCELSRRISEHDQCEWRCMDKTKLTLQAIKDTEAQVDRLRQEAQKAE 402
++ Q + E +RR +E + E + + Q+ + E + +RL+Q A++
Sbjct: 2096 LQQEQSVLDQLRGEAEAARRAAE--EAEEARVQAEREAAQSRRQVE-EAERLKQSAEEQA 2152
Query: 403 EALAMARLELREQTQEGEEEA 423
+A A A+ + +E E+EA
Sbjct: 2153 QARAQAQAAAEKLRKEAEQEA 2173
Score = 62.4 bits (150), Expect = 1e-09
Identities = 84/346 (24%), Positives = 139/346 (40%), Gaps = 45/346 (13%)
Query: 121 TPQKEAYLAPVRREQEAARRLREQEEAAQRERREE----LQRRRRLLDAAFDGDVGEIRA 176
T Q +++ R E RL EQ+ A +RER E L+++R+L +A R
Sbjct: 1357 TSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAERE 1416
Query: 177 VLKEVEQLLTREGVGHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQ---- 232
KE++Q + E V +EA + Q+R E + ++ A Q A +
Sbjct: 1417 A-KELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRL 1475
Query: 233 --------LRAELGASPNSK-GAFGPTPLYRAAFGGHLAAVEVLLKLGADPRVYAEDGST 283
+R +L A+ + GA G RA A + R +D S
Sbjct: 1476 RIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQ 1535
Query: 284 PERVASLDTVVSVLRSWDL---------SLTEAMLQNMEAEQQRRAQEAQR--------- 325
+R A ++ V + +L E LQ EAE++ R E +R
Sbjct: 1536 RKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALE 1595
Query: 326 --HKEAEAERMTL------KVQQLTREQQQCHKELQQAYCELSRRISEHDQCEWRCMDKT 377
+ AEAE + K QL R Q+ H + Q E RR + + E R ++
Sbjct: 1596 TAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAE-RAREEA 1654
Query: 378 KLTLQAIKDTEAQVDRLRQEAQKAEEALAMARLELREQTQEGEEEA 423
+ L+ + + RLR +A++ + ++A+ E +Q +E E EA
Sbjct: 1655 ERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREA 1700
Score = 60.8 bits (146), Expect = 3e-09
Identities = 100/457 (21%), Positives = 186/457 (40%), Gaps = 74/457 (16%)
Query: 28 ELRARRGSQDPRRRGAGEVPADLGPLRVPGS---RAASSCGL-CGREPRLGRAGGFESRP 83
E+ A + S + G E+ +LG +R R+ L R+ +L R
Sbjct: 1953 EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRRE 2012
Query: 84 AEDRAARAIQGAFRQLRARRELARRREERREYLEQMETPQKEAYLAPVRREQEAARRLRE 143
AE+R ++ L A E AR+R+ E +E+++ +EA R EQE+AR+L+
Sbjct: 2013 AEERVQKS-------LAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQL 2065
Query: 144 QEEAAQR--------------ERREELQRRRRLLDAAFDGDVGEIRAVLKEVEQLLTREG 189
+EAAQ+ ++ +ELQ+ + + D GE A + E+
Sbjct: 2066 AQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARV 2125
Query: 190 VGHDEAGEARR-LQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFG 248
EA ++RR ++ L + + ++A A Q A +LR E +
Sbjct: 2126 QAEREAAQSRRQVEEAERLKQSAEEQ-----AQARAQAQAAAEKLRKEAEQEAARRAQAE 2180
Query: 249 PTPLYR-----AAFGGHLAAVEVLLKLGADP-------RVYAEDGSTPERVASLDTVVSV 296
L + A H E L+ A R+ E+ T + LD +
Sbjct: 2181 QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE--TDHQKNLLDEELQR 2238
Query: 297 LRSWDLSLTEAMLQNMEAEQQRRAQEAQRHK--------EAEAERMTLK----VQQLTRE 344
L++ TEA Q + E++ + Q + EAE + L+ Q+ +E
Sbjct: 2239 LKA---EATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQE 2295
Query: 345 QQQCHKELQQAYCELS---------RRISEHDQCEWRCMDKTKL--TLQAIKDT---EAQ 390
+ + K++ + LS R+++E D + R + + L +QA+++ +A+
Sbjct: 2296 EAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAE 2355
Query: 391 VDRLRQEAQKAEEALAMARLELREQTQEGEEEAPGLK 427
+ L+Q+ + A+E + + + Q+ EE G +
Sbjct: 2356 AELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQ 2392
Score = 56.2 bits (134), Expect = 8e-08
Identities = 80/342 (23%), Positives = 147/342 (42%), Gaps = 26/342 (7%)
Query: 84 AEDRAARAIQGAFRQLRARRELARRR-EERREYLEQMETPQKEAYLAPVRRE--QEAARR 140
A AAR Q A L +R LA + +E+ + +++ + EA L ++E QE ARR
Sbjct: 2313 AAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARR 2372
Query: 141 LREQEEAAQRERREELQRRRRLLDAAFDGDVGEIRAVLKEVEQLLTREGVGHDEAGEARR 200
L+E +E ++ EE Q +R L+A + E+ A E E+L R V +AR
Sbjct: 2373 LQEDKEQMAQQLAEETQGFQRTLEAERQRQL-EMSA---EAERLKLR--VAEMSRAQARA 2426
Query: 201 LQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGH 260
+ + + G A + + + E+ + A R A
Sbjct: 2427 EEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDA----ERLREAIAEL 2482
Query: 261 LAAVEVLLKLGADPRVYAEDGSTPERVASLDTVVSVLRSWDLSLTEAMLQNMEAEQQRRA 320
E L + ++ +E+ T ++ L ++ +S+ LS +++LQ +Q +A
Sbjct: 2483 EREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSF-LSEKDSLLQRERFIEQEKA 2541
Query: 321 QEAQRHKEAEAERMTLKVQQLTREQQQCHKELQQAYCELSRRISEHDQCEWRCMDKTKLT 380
+ Q ++ A+ L+ +Q R+QQQ +E Q+ + + E
Sbjct: 2542 KLEQLFQDEVAKAQQLREEQ-QRQQQQMEQERQRLVASMEEARRRQHEAE---------- 2590
Query: 381 LQAIKDTEAQVDRLRQEAQKAEEALAMARLELREQTQEGEEE 422
+ ++ + ++ +L Q+ ++ EE LA LREQ Q EE+
Sbjct: 2591 -EGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2631
Score = 53.1 bits (126), Expect = 7e-07
Identities = 96/432 (22%), Positives = 162/432 (37%), Gaps = 50/432 (11%)
Query: 28 ELRARRGSQDPRRRGAGEVPADLGPLRVPGSRAASSCGLCGREPRLGRAGGFESRPAEDR 87
E+R R + R G +L LR A + E R R +D
Sbjct: 1480 EIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLR------RQVQDE 1533
Query: 88 AARAIQGAFR---QLRARRELARRREERREYLEQMETPQKEAYLAPVRREQEAARRLREQ 144
+ R Q +++A E AR ++ + LE++ +EA + E E AR+++
Sbjct: 1534 SQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVA 1593
Query: 145 EEAAQRERREELQRRRRLLDAAFDGDVGEIRAVLKE----VEQLLTREGVGHDEAGEARR 200
E AQR ELQ +R A+F ++ L+E V QL + EA R
Sbjct: 1594 LETAQRSAEAELQSKR----ASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAER 1649
Query: 201 LQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGH 260
+ AE E +EA L ++L+AE A S
Sbjct: 1650 AREE---AERELERWQLKANEA------LRLRLQAEEVAQQKS----------------- 1683
Query: 261 LAAVEVLLKLGADPRVYAEDGSTPERVASLDTVVSVLRSWDLSLTEAMLQNMEAEQQRRA 320
LA E + R G E+ + L E Q A +Q
Sbjct: 1684 LAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELI 1743
Query: 321 QEAQRHKEAEAERMTL--KVQQLTREQQQCHKELQQAYCELSRRISEHD---QCEWRCMD 375
+ ++ E +R L ++ +L RE ++ Q+ EL++ +E + + R +
Sbjct: 1744 RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE 1803
Query: 376 KTKLTLQAIKD-TEAQVDRLRQEAQKAEEALAMARLELREQTQEGEEEAPGLKCQVTELH 434
+++ T + K EA+ R R+ A++A A+A E + Q Q EE+A + + +
Sbjct: 1804 ESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE-EAKRQRQLAEEDAARQRAEAERVL 1862
Query: 435 DVLMKDVGNRIR 446
+ +G R
Sbjct: 1863 AEKLAAIGEATR 1874
Score = 50.4 bits (119), Expect = 4e-06
Identities = 81/387 (20%), Positives = 148/387 (38%), Gaps = 43/387 (11%)
Query: 80 ESRPAEDRAARAIQGAFRQLRARRELARRREERREYLEQMETPQKEAYLAPVRREQEAAR 139
+SR + A R Q A Q +AR + E+ R+ EQ + +A A +R++Q A
Sbjct: 2133 QSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADA 2192
Query: 140 RLR----------------EQEEAAQRERREELQRRRRLLDAAFD---GDVGEIRAVLKE 180
+ EQE R + EE ++ LLD + E +
Sbjct: 2193 EMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQ 2252
Query: 181 VEQLLTREGVGHDEAGEAR---RLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAEL 237
VE+ L V +E + + + R + +D+ EA Q R +
Sbjct: 2253 VEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSV 2312
Query: 238 GASPNSK-------GAFGPTPLYRAAFGGHLAAVEVLLKLGADPRVYAEDGS-TPERVAS 289
A ++ L + AV+ +L A+ + + E+
Sbjct: 2313 AAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARR 2372
Query: 290 LDTVVSVLRSWDLSLTEAMLQNMEAEQQRRAQEAQRHKEAEAERMTLKVQQLTREQQQCH 349
L + T+ + +EAE+QR Q AEAER+ L+V +++R Q +
Sbjct: 2373 LQEDKEQMAQQLAEETQGFQRTLEAERQR-----QLEMSAEAERLKLRVAEMSRAQARAE 2427
Query: 350 KELQQAYCELSRRISEHDQCEWRCMDKTKLTLQAIKDTEAQVDRLRQEAQKAEEALAMAR 409
++ Q+ + + + I E + +T+L Q ++ RQ++ E L A
Sbjct: 2428 EDAQR-FRKQAEEIGEK-------LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAI 2479
Query: 410 LELREQTQEGEEEAPGLKCQVTELHDV 436
EL + ++ ++EA L+ + E+ V
Sbjct: 2480 AELEREKEKLQQEAKLLQLKSEEMQTV 2506
Score = 40.0 bits (92), Expect = 0.006
Identities = 86/376 (22%), Positives = 139/376 (36%), Gaps = 60/376 (15%)
Query: 90 RAIQGAFRQLRARRELARRREERREYLEQMETPQKEAYLAPVRREQEAAR----RLREQE 145
R QGA LRA E + + L ++E + A L +R + EA + LR++
Sbjct: 1123 RGTQGAEEVLRAHEEQLKEAQAVPATLPELEATK--ASLKKLRAQAEAQQPTFDALRDEL 1180
Query: 146 EAAQRERREELQRRRRLLDAAFDGDVGEIRAVLKEVEQLLTREGVGH---DEAGEARRLQ 202
AQ E E LQ+R D + + +L+ + +L + V ++ G R
Sbjct: 1181 RGAQ-EVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYY 1239
Query: 203 RRVAL---AECEDSYGNTPLSEAA--AGGQPLAIQLRAELGASPN--------------S 243
R A A +D+ +A A Q + QLR E +
Sbjct: 1240 RESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFA 1299
Query: 244 KGAFGPTPLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVASLDTVVS---VLRSW 300
K Y + A +E + P+V + S + L T S L S
Sbjct: 1300 KQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQ 1359
Query: 301 DLSLTEAMLQNMEAEQ----QRRAQEAQRHKEAEAERMTLKVQQLTREQQQCHKELQQAY 356
+ L+ ME E+ Q+RA+E R + AE E K +QL Q + ++
Sbjct: 1360 YIKFISETLRRMEEEERLAEQQRAEE--RERLAEVEAALEKQRQLAEAHAQAKAQAEREA 1417
Query: 357 CELSRRISEHDQCEWRCMDKTKLTLQAIKDTEAQVDRLRQEAQKAEEALAMARLELREQT 416
EL +R+ E + ++ EA VD +Q+ EE L+ Q+
Sbjct: 1418 KELQQRMQE----------------EVVRREEAAVDAQQQKRSIQEE------LQQLRQS 1455
Query: 417 QEGEEEAPGLKCQVTE 432
E E +A + + E
Sbjct: 1456 SEAEIQAKARQAEAAE 1471
Score = 32.7 bits (73), Expect = 0.94
Identities = 30/104 (28%), Positives = 46/104 (44%), Gaps = 20/104 (19%)
Query: 109 REERREYLEQMETPQKEAYLAPVRREQEAARRLREQEEAAQRERREELQRRRRLLDAAFD 168
REE++ +QME ++ V +EA RR E EE +R ++EELQ
Sbjct: 2558 REEQQRQQQQMEQERQRL----VASMEEARRRQHEAEEGVRR-KQEELQ----------- 2601
Query: 169 GDVGEIRAVLKEVEQLLTREGVGHDEAGEARRLQRRVALAECED 212
++ ++ E+LL E E + Q R ALA E+
Sbjct: 2602 ----QLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEE 2641
Score = 32.0 bits (71), Expect = 1.6
Identities = 20/68 (29%), Positives = 31/68 (45%)
Query: 87 RAARAIQGAFRQLRARRELARRREERREYLEQMETPQKEAYLAPVRREQEAARRLREQEE 146
R +++ A R+ E RR++E + LEQ Q+E +R +E + L EQ
Sbjct: 2574 RLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHR 2633
Query: 147 AAQRERRE 154
AA E
Sbjct: 2634 AALAHSEE 2641
Score = 31.6 bits (70), Expect = 2.1
Identities = 40/151 (26%), Positives = 62/151 (41%), Gaps = 25/151 (16%)
Query: 289 SLDTVVSVLRSWDLSLTEAMLQNMEAEQQRRAQEA-QRHKEA------------EAERMT 335
SL V ++RSW L A + ++ E+QR+A + + H +A +R+
Sbjct: 925 SLRRDVQLIRSWSL----ATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLM 980
Query: 336 LKVQQLTREQQQCHKELQQAYCELSRRISEHDQCEWRCMDKTK-LTLQAIKDTEAQVDRL 394
+ RE C QQ L + E +C+ RC+ + K + LQ V RL
Sbjct: 981 AE-----REYGSCSHHYQQLLQSLEQGAQEESRCQ-RCISELKDIRLQLEACETRTVHRL 1034
Query: 395 RQEAQKAEEALAMARLELREQTQEGEEEAPG 425
R K E A A+ +Q + E E G
Sbjct: 1035 RLPLDK-EPARECAQRIAEQQKAQAEVEGLG 1064
>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
Length = 1897
Score = 60.5 bits (145), Expect = 4e-09
Identities = 51/170 (30%), Positives = 77/170 (45%), Gaps = 15/170 (8%)
Query: 134 EQEAARRLREQEEAAQRERREELQRRRR------LLDAAFDGDVGEIRAVLKEVEQLLTR 187
E +A + +E+EE+ ++ R R+++ L AA G++ + L+ + T
Sbjct: 15 EAQALQEQKEKEESNRKRRNRSRDRKKKADAATSFLRAARSGNLDKALDHLRNGVDINTC 74
Query: 188 EGVG----HDEAGEAR-----RLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELG 238
G H + E L + + E GNT L AA GQ ++ G
Sbjct: 75 NQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYG 134
Query: 239 ASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVA 288
A+ N++ G TPLY AA HL V+ LL+ GA+ V EDG TP VA
Sbjct: 135 ANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVA 184
Score = 53.5 bits (127), Expect = 5e-07
Identities = 40/109 (36%), Positives = 51/109 (46%), Gaps = 2/109 (1%)
Query: 191 GHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPT 250
GH E A L + A C G TPL AA G+ +L E A PN+ G G T
Sbjct: 547 GHVETVLA--LLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLT 604
Query: 251 PLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVASLDTVVSVLRS 299
PL+ A +L V++LL G P A +G TP +A+ V V RS
Sbjct: 605 PLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARS 653
Score = 50.1 bits (118), Expect = 6e-06
Identities = 30/73 (41%), Positives = 38/73 (52%)
Query: 217 TPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADPRV 276
TPL AA G ++ + GA PNS+ G TPL+ A H+ +E+LLK GA
Sbjct: 373 TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDA 432
Query: 277 YAEDGSTPERVAS 289
E G TP VAS
Sbjct: 433 VTESGLTPLHVAS 445
Score = 49.3 bits (116), Expect = 1e-05
Identities = 30/82 (36%), Positives = 43/82 (52%)
Query: 215 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADP 274
G TPL A+ G ++ + A N+K G +PL++AA GH V +LLK GA P
Sbjct: 734 GYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASP 793
Query: 275 RVYAEDGSTPERVASLDTVVSV 296
+ DG+TP +A +SV
Sbjct: 794 NEVSSDGTTPLAIAKRLGYISV 815
Score = 44.7 bits (104), Expect = 2e-04
Identities = 34/99 (34%), Positives = 45/99 (45%), Gaps = 2/99 (2%)
Query: 191 GHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPT 250
GH E A+ L + A + TPL AA G ++L E A+PN G T
Sbjct: 481 GHTEV--AKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHT 538
Query: 251 PLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVAS 289
PL+ AA GH+ V LL+ A + G TP VA+
Sbjct: 539 PLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAA 577
Score = 43.9 bits (102), Expect = 4e-04
Identities = 35/110 (31%), Positives = 55/110 (50%), Gaps = 9/110 (8%)
Query: 215 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADP 274
G TPL A ++L + GAS ++ G TPL+ A+F GHL V+ LL+ GA P
Sbjct: 404 GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASP 463
Query: 275 RVYAEDGSTPERVASLDTVVSVLRSWDLSLTEAMLQNMEAEQQRRAQEAQ 324
V TP +A+ R+ + + +LQN +A+ +A++ Q
Sbjct: 464 NVSNVKVETPLHMAA--------RAGHTEVAKYLLQN-KAKVNAKAKDDQ 504
Score = 43.5 bits (101), Expect = 5e-04
Identities = 35/125 (28%), Positives = 59/125 (47%), Gaps = 5/125 (4%)
Query: 192 HDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTP 251
++ A+ L R A G TPL A+ G + ++L + GA +K TP
Sbjct: 249 YENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTP 308
Query: 252 LYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVAS----LDTVVSVLRSWDLSLTEA 307
L+ AA GH+ E+LL GA + ++G +P +A+ LD V +L +D + +
Sbjct: 309 LHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLD-CVRLLLQYDAEIDDI 367
Query: 308 MLQNM 312
L ++
Sbjct: 368 TLDHL 372
Score = 42.0 bits (97), Expect = 0.002
Identities = 32/92 (34%), Positives = 39/92 (42%)
Query: 198 ARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAF 257
AR L + A E G TPL AA G + L A+ N G TPL+ A
Sbjct: 651 ARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQ 710
Query: 258 GGHLAAVEVLLKLGADPRVYAEDGSTPERVAS 289
GH+ +VL+K G G TP VAS
Sbjct: 711 EGHVPVADVLIKHGVMVDATTRMGYTPLHVAS 742
Score = 41.6 bits (96), Expect = 0.002
Identities = 31/103 (30%), Positives = 50/103 (48%), Gaps = 4/103 (3%)
Query: 199 RRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFG 258
+ L +R A + TPL AA G + + A N+K TPL+ AA
Sbjct: 454 KNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARI 513
Query: 259 GHLAAVEVLLKLGADPRVYAEDGSTPERVAS----LDTVVSVL 297
GH V++LL+ A+P + G TP +A+ ++TV+++L
Sbjct: 514 GHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALL 556
Score = 39.7 bits (91), Expect = 0.008
Identities = 26/75 (34%), Positives = 35/75 (46%)
Query: 215 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADP 274
G TPL A+ G ++ + GASPN TPL+ AA GH + LL+ A
Sbjct: 437 GLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKV 496
Query: 275 RVYAEDGSTPERVAS 289
A+D TP A+
Sbjct: 497 NAKAKDDQTPLHCAA 511
Score = 39.3 bits (90), Expect = 0.010
Identities = 27/82 (32%), Positives = 39/82 (47%)
Query: 215 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADP 274
G TPL AA Q + + G S N++ G TPL+ AA GH V +LL A+
Sbjct: 635 GYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANG 694
Query: 275 RVYAEDGSTPERVASLDTVVSV 296
+ + G TP + + + V V
Sbjct: 695 NLGNKSGLTPLHLVAQEGHVPV 716
Score = 38.1 bits (87), Expect = 0.022
Identities = 27/74 (36%), Positives = 35/74 (47%)
Query: 215 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADP 274
G+TPL AA G + E AS G TPL+ AA G + E+LL+ A P
Sbjct: 536 GHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHP 595
Query: 275 RVYAEDGSTPERVA 288
++G TP VA
Sbjct: 596 NAAGKNGLTPLHVA 609
Score = 37.4 bits (85), Expect = 0.038
Identities = 30/91 (32%), Positives = 42/91 (46%)
Query: 199 RRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFG 258
R L R A E + TPL AA G ++ + GA +K G +P++ AA G
Sbjct: 289 RLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQG 348
Query: 259 GHLAAVEVLLKLGADPRVYAEDGSTPERVAS 289
HL V +LL+ A+ D TP VA+
Sbjct: 349 DHLDCVRLLLQYDAEIDDITLDHLTPLHVAA 379
Score = 36.6 bits (83), Expect = 0.065
Identities = 27/83 (32%), Positives = 38/83 (45%)
Query: 215 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADP 274
G +P+ AA G ++L + A + TPL+ AA GH +VLL GA P
Sbjct: 338 GLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKP 397
Query: 275 RVYAEDGSTPERVASLDTVVSVL 297
A +G TP +A V V+
Sbjct: 398 NSRALNGFTPLHIACKKNHVRVM 420
Score = 36.2 bits (82), Expect = 0.085
Identities = 38/134 (28%), Positives = 55/134 (41%), Gaps = 9/134 (6%)
Query: 165 AAFDGDVGEIRAVL-KEVEQL-LTREG-------VGHDEAGEARRLQRRVALAECEDSYG 215
AA +G V + A+L KE Q +T++G + + A L R A G
Sbjct: 543 AAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNG 602
Query: 216 NTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADPR 275
TPL A ++L G SP+S G TPL+ AA + LL+ G
Sbjct: 603 LTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSAN 662
Query: 276 VYAEDGSTPERVAS 289
+ G TP +A+
Sbjct: 663 AESVQGVTPLHLAA 676
Score = 35.0 bits (79), Expect = 0.19
Identities = 20/53 (37%), Positives = 29/53 (54%)
Query: 215 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVL 267
G +PL +AA G + L + GASPN + G TPL A G+++ +VL
Sbjct: 767 GYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 819
Score = 34.3 bits (77), Expect = 0.32
Identities = 27/75 (36%), Positives = 34/75 (45%)
Query: 215 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADP 274
G TPL AA QL GAS N G TPL+ A+ G++ V +LL GA
Sbjct: 239 GFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQI 298
Query: 275 RVYAEDGSTPERVAS 289
+D TP A+
Sbjct: 299 ETKTKDELTPLHCAA 313
Score = 29.6 bits (65), Expect = 8.0
Identities = 27/86 (31%), Positives = 33/86 (38%), Gaps = 2/86 (2%)
Query: 191 GHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPT 250
G DE R L A + G TPL AA ++ E GA+ N G T
Sbjct: 122 GQDEV--VRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFT 179
Query: 251 PLYRAAFGGHLAAVEVLLKLGADPRV 276
PL A GH V L+ G +V
Sbjct: 180 PLAVALQQGHENVVAHLINYGTKGKV 205
>gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]
Length = 2003
Score = 60.1 bits (144), Expect = 5e-09
Identities = 118/497 (23%), Positives = 187/497 (37%), Gaps = 69/497 (13%)
Query: 26 APELRARRGSQDPRRRGAGEVPADLGPLRVPGSRAASSCGLCGREPRLGRAG-GFES-RP 83
A ELRA+ G ++ + A D G G+RA L + L A ES R
Sbjct: 1103 AEELRAQLGRKEEELQAALARAEDEG-----GARAQLLKSLREAQAALAEAQEDLESERV 1157
Query: 84 AEDRAARAIQGAFRQLRARR-------ELARRREERREYLEQMETPQKEAYLAPVRREQE 136
A +A + + +L A R + ++E R EQ T K+ R +
Sbjct: 1158 ARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEA 1217
Query: 137 AARRLREQEEAAQRERREELQRRRRLLDA------AFDGDVGEIRAVLKEVEQLLTREGV 190
A + LR++ A E E+L++ RR A A + +V E+RA L ++
Sbjct: 1218 AVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTA------ 1271
Query: 191 GHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPT 250
+ GE RR + + L E + G+ + A A + Q E N GA
Sbjct: 1272 --RQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELE-----NVSGALNEA 1324
Query: 251 PLYRAAFGGHLAAVEVLL-------------KLGADPRVYAEDGST-------PERVASL 290
L++ E L KL RV A + E A+
Sbjct: 1325 ESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAAR 1384
Query: 291 DTVVSVLRSWDLSLTE-AMLQNMEAEQQRRAQEAQRHKEAEAERMTLKVQQLTR---EQQ 346
+ L++ L+E Q EA +EA+R EAE +T ++ + T +
Sbjct: 1385 ERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLE 1444
Query: 347 QCHKELQQAYCELSRRISEHDQCEWRCMDKTKLTLQAIKDTEAQVDRLRQEAQKAE---- 402
+ + LQQ + + + + Q K + Q + + +A V R +E ++AE
Sbjct: 1445 RGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGR 1504
Query: 403 --EALAMARLELREQTQEGEEEAPGLKCQVTELHDVLMK---DVGNRIRADGRWPLVIDP 457
EA A++ E+ QE EE + + L+ DVG + R V +
Sbjct: 1505 EREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAE- 1563
Query: 458 LGQAATFLRYQDTNYVD 474
QAA LR Q T D
Sbjct: 1564 --QAANDLRAQVTELED 1578
Score = 53.5 bits (127), Expect = 5e-07
Identities = 99/405 (24%), Positives = 153/405 (37%), Gaps = 90/405 (22%)
Query: 87 RAARAIQGAFRQLRARRELARRREERREYLEQMETPQKEAYLAPVRREQEAARRLREQEE 146
R + + A L +R+L E+++ +Q+ +K A L V + A RE+E
Sbjct: 1449 RLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREA 1508
Query: 147 AA---------QRERREELQRRRRLLDAAFDG------DVG------------------E 173
A ++E REEL+R+ R L A + DVG +
Sbjct: 1509 RALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAAND 1568
Query: 174 IRAVLKEVEQLLT---------------------REGVGHDEAGEARR--LQRRVALAEC 210
+RA + E+E LT R+ G DEAGE RR L +++ AE
Sbjct: 1569 LRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEV 1628
Query: 211 EDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKL 270
E + A A + L +L EL A S G G AV+ L K+
Sbjct: 1629 ERDEERKQRTLAVAARKKLEGELE-ELKAQMASAGQ------------GKEEAVKQLRKM 1675
Query: 271 GADP----RVYAEDGSTPERVASLDTVVSVLRSWDLSLTEAMLQNMEAEQQRRAQEAQRH 326
A R E ++ E + S + S R L LQ A R ++AQ+
Sbjct: 1676 QAQMKELWREVEETRTSREEIFSQNR-ESEKRLKGLEAEVLRLQEELAASDRARRQAQQD 1734
Query: 327 KEAEAERM---TLKVQQLTREQQQCHKELQQAYCELSRRISEHDQCEWRCMDKTKLTLQA 383
++ A+ + L + E++Q L Q EL S + D+ + L
Sbjct: 1735 RDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLN----DRYRKLLLQ 1790
Query: 384 IKDTEAQVDRLRQEAQKAEEALAMARLELREQTQE-----GEEEA 423
++ ++ R + KAE R +L Q QE GEE+A
Sbjct: 1791 VESLTTELSAERSFSAKAES----GRQQLERQIQELRGRLGEEDA 1831
Score = 40.4 bits (93), Expect = 0.005
Identities = 81/378 (21%), Positives = 147/378 (38%), Gaps = 48/378 (12%)
Query: 80 ESRPAEDRAARAIQGAFRQLRARRELARRREERREYLEQMETPQKEAYLAPVRREQEAAR 139
E + EDR A A + + L + R + + ME ++ R+E E +
Sbjct: 1025 ERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKG--RQELEKLK 1082
Query: 140 RLREQEEAAQRERREELQRRRRLLDAAFDGDVGEIRAVLKEVEQLLTREGVGHDEAGEAR 199
R + E + +E+ E Q+R L A E++A L E DE G
Sbjct: 1083 RRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAE----------DEGGARA 1132
Query: 200 RL-----QRRVALAECEDSYGNTPLSEAAAGGQ--PLAIQLRAELGASPNSKGAFGPTPL 252
+L + + ALAE ++ + ++ A Q L +L A G ++ +
Sbjct: 1133 QLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQE 1192
Query: 253 YRAAFGGHLAAVEVLLKLGADPRVY---------AEDGSTPERVASLDTVVSVLRSWDLS 303
R+ E+ L + R++ + E L+ +W+ +
Sbjct: 1193 LRSK--REQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKT 1250
Query: 304 --LTEAMLQNMEAEQQRRAQEAQRHKEAEAERMTLKVQQL-------TREQQQCHKELQQ 354
EA + + AE Q A++ E R+ L++Q++ R + + ++LQ+
Sbjct: 1251 RLALEAEVSELRAELS-SLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQR 1309
Query: 355 AYCELSRRISEHDQCEWRCMDKTKLTLQAIKDTEAQVDRLRQEAQKAEEALAMARLELRE 414
A EL ++ E KT + + TEAQ+ +AQ+ + A+L L
Sbjct: 1310 AQAELENVSGALNEAE----SKTIRLSKELSSTEAQL----HDAQELLQEETRAKLALGS 1361
Query: 415 QTQEGEEEAPGLKCQVTE 432
+ + E EA GL+ Q+ E
Sbjct: 1362 RVRAMEAEAAGLREQLEE 1379
Score = 40.0 bits (92), Expect = 0.006
Identities = 48/193 (24%), Positives = 90/193 (46%), Gaps = 33/193 (17%)
Query: 269 KLGADPRVYAEDGSTPERVAS----LDTVVSVLRSWDLSLTEAMLQNMEAEQQR---RAQ 321
+L A+ + AE T R+A+ L+ VVS L + + E + M+ E++R Q
Sbjct: 920 QLRAEAELCAEAEETRGRLAARKQELELVVSELEA-RVGEEEECSRQMQTEKKRLQQHIQ 978
Query: 322 EAQRHKEAE-AERMTLKVQQLTREQQQC-------------------HKELQQAYCELSR 361
E + H EAE R L+++++T E + K L+ E S
Sbjct: 979 ELEAHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSS 1038
Query: 362 RISEHDQCEWRCMDKTKLTLQA----IKDTEAQVDRLRQEAQKAEEALAMARLELREQTQ 417
+ +E ++ + + ++K +L +A ++D + ++ RQE +K + L EL+EQ
Sbjct: 1039 QAAEEEE-KVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMV 1097
Query: 418 EGEEEAPGLKCQV 430
E ++ A L+ Q+
Sbjct: 1098 EQQQRAEELRAQL 1110
Score = 38.9 bits (89), Expect = 0.013
Identities = 88/406 (21%), Positives = 161/406 (39%), Gaps = 58/406 (14%)
Query: 86 DRAARAIQGAFRQLRAR-----RELARRREERREY---LEQMETPQKEAYLAPVRREQEA 137
+RA R + A LRA+ EL + + ++ ++T + +E
Sbjct: 1556 ERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEER 1615
Query: 138 ARRLREQEEAAQRERREELQRRRRLLDAAFDGDVGEIRAVLKEVEQLLTREGVGHDEA-- 195
R+L +Q A+ ER EE +++R L AA GE L+E++ + G G +EA
Sbjct: 1616 RRQLAKQLRDAEVERDEE-RKQRTLAVAARKKLEGE----LEELKAQMASAGQGKEEAVK 1670
Query: 196 ------GEARRLQRRVALAEC--EDSYGNTPLSEAAAGG-QPLAIQLRAELGASPNSK-- 244
+ + L R V E+ + SE G + ++L+ EL AS ++
Sbjct: 1671 QLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQ 1730
Query: 245 GAFGPTPLYRAAFGGHLAAVEVLL-------KLGADPRVYAEDGSTPE-----------R 286
+ G+L+ +L +LG E+ S E +
Sbjct: 1731 AQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQ 1790
Query: 287 VASLDTVVSVLRSWDLSLTEAMLQNMEAEQQRRAQEAQ-------RHK------EAEAER 333
V SL T +S RS+ Q Q+ R + + RHK E++ +
Sbjct: 1791 VESLTTELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARARHKMTIAALESKLAQ 1850
Query: 334 MTLKVQQLTREQQQCHKELQQAYCELSRRISEHDQCEWRCMDKTKLTLQAIKDTEAQVDR 393
+++Q TRE+ K +++A L + + ++ E R D+ + L+ Q+ R
Sbjct: 1851 AEEQLEQETRERILSGKLVRRAEKRLKEVVLQVEE-ERRVADQLRDQLEKGNLRVKQLKR 1909
Query: 394 LRQEAQKAEEALAMARLELREQTQEGEEEAPGLKCQVTELHDVLMK 439
+EA++ R L+ + ++ E A + +VT L + L +
Sbjct: 1910 QLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRLRR 1955
Score = 35.8 bits (81), Expect = 0.11
Identities = 29/115 (25%), Positives = 53/115 (46%), Gaps = 14/115 (12%)
Query: 306 EAMLQNMEAEQQRRAQEAQRHKEAEAERMTLKVQQLTREQQQCHKELQQAYCELSRRISE 365
+ + +E E+ R A++ + E AE + + R+Q EL+ EL R+ E
Sbjct: 904 QGRVAQLEEERARLAEQLRAEAELCAEAEETRGRLAARKQ-----ELELVVSELEARVGE 958
Query: 366 HDQCEWRCMDKTKLTLQAIKDTEAQVDRLRQEAQKAEEALAMARLELREQTQEGE 420
++C + + K Q I++ EA ++ AEE A +L+L + T E +
Sbjct: 959 EEECSRQMQTEKKRLQQHIQELEAHLE--------AEEG-ARQKLQLEKVTTEAK 1004
>gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]
Length = 1995
Score = 60.1 bits (144), Expect = 5e-09
Identities = 118/497 (23%), Positives = 187/497 (37%), Gaps = 69/497 (13%)
Query: 26 APELRARRGSQDPRRRGAGEVPADLGPLRVPGSRAASSCGLCGREPRLGRAG-GFES-RP 83
A ELRA+ G ++ + A D G G+RA L + L A ES R
Sbjct: 1095 AEELRAQLGRKEEELQAALARAEDEG-----GARAQLLKSLREAQAALAEAQEDLESERV 1149
Query: 84 AEDRAARAIQGAFRQLRARR-------ELARRREERREYLEQMETPQKEAYLAPVRREQE 136
A +A + + +L A R + ++E R EQ T K+ R +
Sbjct: 1150 ARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEA 1209
Query: 137 AARRLREQEEAAQRERREELQRRRRLLDA------AFDGDVGEIRAVLKEVEQLLTREGV 190
A + LR++ A E E+L++ RR A A + +V E+RA L ++
Sbjct: 1210 AVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTA------ 1263
Query: 191 GHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPT 250
+ GE RR + + L E + G+ + A A + Q E N GA
Sbjct: 1264 --RQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELE-----NVSGALNEA 1316
Query: 251 PLYRAAFGGHLAAVEVLL-------------KLGADPRVYAEDGST-------PERVASL 290
L++ E L KL RV A + E A+
Sbjct: 1317 ESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAAR 1376
Query: 291 DTVVSVLRSWDLSLTE-AMLQNMEAEQQRRAQEAQRHKEAEAERMTLKVQQLTR---EQQ 346
+ L++ L+E Q EA +EA+R EAE +T ++ + T +
Sbjct: 1377 ERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLE 1436
Query: 347 QCHKELQQAYCELSRRISEHDQCEWRCMDKTKLTLQAIKDTEAQVDRLRQEAQKAE---- 402
+ + LQQ + + + + Q K + Q + + +A V R +E ++AE
Sbjct: 1437 RGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGR 1496
Query: 403 --EALAMARLELREQTQEGEEEAPGLKCQVTELHDVLMK---DVGNRIRADGRWPLVIDP 457
EA A++ E+ QE EE + + L+ DVG + R V +
Sbjct: 1497 EREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAE- 1555
Query: 458 LGQAATFLRYQDTNYVD 474
QAA LR Q T D
Sbjct: 1556 --QAANDLRAQVTELED 1570
Score = 53.5 bits (127), Expect = 5e-07
Identities = 99/405 (24%), Positives = 153/405 (37%), Gaps = 90/405 (22%)
Query: 87 RAARAIQGAFRQLRARRELARRREERREYLEQMETPQKEAYLAPVRREQEAARRLREQEE 146
R + + A L +R+L E+++ +Q+ +K A L V + A RE+E
Sbjct: 1441 RLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREA 1500
Query: 147 AA---------QRERREELQRRRRLLDAAFDG------DVG------------------E 173
A ++E REEL+R+ R L A + DVG +
Sbjct: 1501 RALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAAND 1560
Query: 174 IRAVLKEVEQLLT---------------------REGVGHDEAGEARR--LQRRVALAEC 210
+RA + E+E LT R+ G DEAGE RR L +++ AE
Sbjct: 1561 LRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEV 1620
Query: 211 EDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKL 270
E + A A + L +L EL A S G G AV+ L K+
Sbjct: 1621 ERDEERKQRTLAVAARKKLEGELE-ELKAQMASAGQ------------GKEEAVKQLRKM 1667
Query: 271 GADP----RVYAEDGSTPERVASLDTVVSVLRSWDLSLTEAMLQNMEAEQQRRAQEAQRH 326
A R E ++ E + S + S R L LQ A R ++AQ+
Sbjct: 1668 QAQMKELWREVEETRTSREEIFSQNR-ESEKRLKGLEAEVLRLQEELAASDRARRQAQQD 1726
Query: 327 KEAEAERM---TLKVQQLTREQQQCHKELQQAYCELSRRISEHDQCEWRCMDKTKLTLQA 383
++ A+ + L + E++Q L Q EL S + D+ + L
Sbjct: 1727 RDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLN----DRYRKLLLQ 1782
Query: 384 IKDTEAQVDRLRQEAQKAEEALAMARLELREQTQE-----GEEEA 423
++ ++ R + KAE R +L Q QE GEE+A
Sbjct: 1783 VESLTTELSAERSFSAKAES----GRQQLERQIQELRGRLGEEDA 1823
Score = 40.4 bits (93), Expect = 0.005
Identities = 81/378 (21%), Positives = 147/378 (38%), Gaps = 48/378 (12%)
Query: 80 ESRPAEDRAARAIQGAFRQLRARRELARRREERREYLEQMETPQKEAYLAPVRREQEAAR 139
E + EDR A A + + L + R + + ME ++ R+E E +
Sbjct: 1017 ERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKG--RQELEKLK 1074
Query: 140 RLREQEEAAQRERREELQRRRRLLDAAFDGDVGEIRAVLKEVEQLLTREGVGHDEAGEAR 199
R + E + +E+ E Q+R L A E++A L E DE G
Sbjct: 1075 RRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAE----------DEGGARA 1124
Query: 200 RL-----QRRVALAECEDSYGNTPLSEAAAGGQ--PLAIQLRAELGASPNSKGAFGPTPL 252
+L + + ALAE ++ + ++ A Q L +L A G ++ +
Sbjct: 1125 QLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQE 1184
Query: 253 YRAAFGGHLAAVEVLLKLGADPRVY---------AEDGSTPERVASLDTVVSVLRSWDLS 303
R+ E+ L + R++ + E L+ +W+ +
Sbjct: 1185 LRSK--REQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKT 1242
Query: 304 --LTEAMLQNMEAEQQRRAQEAQRHKEAEAERMTLKVQQL-------TREQQQCHKELQQ 354
EA + + AE Q A++ E R+ L++Q++ R + + ++LQ+
Sbjct: 1243 RLALEAEVSELRAELS-SLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQR 1301
Query: 355 AYCELSRRISEHDQCEWRCMDKTKLTLQAIKDTEAQVDRLRQEAQKAEEALAMARLELRE 414
A EL ++ E KT + + TEAQ+ +AQ+ + A+L L
Sbjct: 1302 AQAELENVSGALNEAE----SKTIRLSKELSSTEAQL----HDAQELLQEETRAKLALGS 1353
Query: 415 QTQEGEEEAPGLKCQVTE 432
+ + E EA GL+ Q+ E
Sbjct: 1354 RVRAMEAEAAGLREQLEE 1371
Score = 40.0 bits (92), Expect = 0.006
Identities = 48/193 (24%), Positives = 90/193 (46%), Gaps = 33/193 (17%)
Query: 269 KLGADPRVYAEDGSTPERVAS----LDTVVSVLRSWDLSLTEAMLQNMEAEQQR---RAQ 321
+L A+ + AE T R+A+ L+ VVS L + + E + M+ E++R Q
Sbjct: 912 QLRAEAELCAEAEETRGRLAARKQELELVVSELEA-RVGEEEECSRQMQTEKKRLQQHIQ 970
Query: 322 EAQRHKEAE-AERMTLKVQQLTREQQQC-------------------HKELQQAYCELSR 361
E + H EAE R L+++++T E + K L+ E S
Sbjct: 971 ELEAHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSS 1030
Query: 362 RISEHDQCEWRCMDKTKLTLQA----IKDTEAQVDRLRQEAQKAEEALAMARLELREQTQ 417
+ +E ++ + + ++K +L +A ++D + ++ RQE +K + L EL+EQ
Sbjct: 1031 QAAEEEE-KVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMV 1089
Query: 418 EGEEEAPGLKCQV 430
E ++ A L+ Q+
Sbjct: 1090 EQQQRAEELRAQL 1102
Score = 38.9 bits (89), Expect = 0.013
Identities = 88/406 (21%), Positives = 161/406 (39%), Gaps = 58/406 (14%)
Query: 86 DRAARAIQGAFRQLRAR-----RELARRREERREY---LEQMETPQKEAYLAPVRREQEA 137
+RA R + A LRA+ EL + + ++ ++T + +E
Sbjct: 1548 ERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEER 1607
Query: 138 ARRLREQEEAAQRERREELQRRRRLLDAAFDGDVGEIRAVLKEVEQLLTREGVGHDEA-- 195
R+L +Q A+ ER EE +++R L AA GE L+E++ + G G +EA
Sbjct: 1608 RRQLAKQLRDAEVERDEE-RKQRTLAVAARKKLEGE----LEELKAQMASAGQGKEEAVK 1662
Query: 196 ------GEARRLQRRVALAEC--EDSYGNTPLSEAAAGG-QPLAIQLRAELGASPNSK-- 244
+ + L R V E+ + SE G + ++L+ EL AS ++
Sbjct: 1663 QLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQ 1722
Query: 245 GAFGPTPLYRAAFGGHLAAVEVLL-------KLGADPRVYAEDGSTPE-----------R 286
+ G+L+ +L +LG E+ S E +
Sbjct: 1723 AQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQ 1782
Query: 287 VASLDTVVSVLRSWDLSLTEAMLQNMEAEQQRRAQEAQ-------RHK------EAEAER 333
V SL T +S RS+ Q Q+ R + + RHK E++ +
Sbjct: 1783 VESLTTELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARARHKMTIAALESKLAQ 1842
Query: 334 MTLKVQQLTREQQQCHKELQQAYCELSRRISEHDQCEWRCMDKTKLTLQAIKDTEAQVDR 393
+++Q TRE+ K +++A L + + ++ E R D+ + L+ Q+ R
Sbjct: 1843 AEEQLEQETRERILSGKLVRRAEKRLKEVVLQVEE-ERRVADQLRDQLEKGNLRVKQLKR 1901
Query: 394 LRQEAQKAEEALAMARLELREQTQEGEEEAPGLKCQVTELHDVLMK 439
+EA++ R L+ + ++ E A + +VT L + L +
Sbjct: 1902 QLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRLRR 1947
Score = 35.8 bits (81), Expect = 0.11
Identities = 29/115 (25%), Positives = 53/115 (46%), Gaps = 14/115 (12%)
Query: 306 EAMLQNMEAEQQRRAQEAQRHKEAEAERMTLKVQQLTREQQQCHKELQQAYCELSRRISE 365
+ + +E E+ R A++ + E AE + + R+Q EL+ EL R+ E
Sbjct: 896 QGRVAQLEEERARLAEQLRAEAELCAEAEETRGRLAARKQ-----ELELVVSELEARVGE 950
Query: 366 HDQCEWRCMDKTKLTLQAIKDTEAQVDRLRQEAQKAEEALAMARLELREQTQEGE 420
++C + + K Q I++ EA ++ AEE A +L+L + T E +
Sbjct: 951 EEECSRQMQTEKKRLQQHIQELEAHLE--------AEEG-ARQKLQLEKVTTEAK 996
>gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]
Length = 2036
Score = 60.1 bits (144), Expect = 5e-09
Identities = 118/497 (23%), Positives = 187/497 (37%), Gaps = 69/497 (13%)
Query: 26 APELRARRGSQDPRRRGAGEVPADLGPLRVPGSRAASSCGLCGREPRLGRAG-GFES-RP 83
A ELRA+ G ++ + A D G G+RA L + L A ES R
Sbjct: 1136 AEELRAQLGRKEEELQAALARAEDEG-----GARAQLLKSLREAQAALAEAQEDLESERV 1190
Query: 84 AEDRAARAIQGAFRQLRARR-------ELARRREERREYLEQMETPQKEAYLAPVRREQE 136
A +A + + +L A R + ++E R EQ T K+ R +
Sbjct: 1191 ARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEA 1250
Query: 137 AARRLREQEEAAQRERREELQRRRRLLDA------AFDGDVGEIRAVLKEVEQLLTREGV 190
A + LR++ A E E+L++ RR A A + +V E+RA L ++
Sbjct: 1251 AVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTA------ 1304
Query: 191 GHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPT 250
+ GE RR + + L E + G+ + A A + Q E N GA
Sbjct: 1305 --RQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELE-----NVSGALNEA 1357
Query: 251 PLYRAAFGGHLAAVEVLL-------------KLGADPRVYAEDGST-------PERVASL 290
L++ E L KL RV A + E A+
Sbjct: 1358 ESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAAR 1417
Query: 291 DTVVSVLRSWDLSLTE-AMLQNMEAEQQRRAQEAQRHKEAEAERMTLKVQQLTR---EQQ 346
+ L++ L+E Q EA +EA+R EAE +T ++ + T +
Sbjct: 1418 ERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLE 1477
Query: 347 QCHKELQQAYCELSRRISEHDQCEWRCMDKTKLTLQAIKDTEAQVDRLRQEAQKAE---- 402
+ + LQQ + + + + Q K + Q + + +A V R +E ++AE
Sbjct: 1478 RGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGR 1537
Query: 403 --EALAMARLELREQTQEGEEEAPGLKCQVTELHDVLMK---DVGNRIRADGRWPLVIDP 457
EA A++ E+ QE EE + + L+ DVG + R V +
Sbjct: 1538 EREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAE- 1596
Query: 458 LGQAATFLRYQDTNYVD 474
QAA LR Q T D
Sbjct: 1597 --QAANDLRAQVTELED 1611
Score = 53.5 bits (127), Expect = 5e-07
Identities = 99/405 (24%), Positives = 153/405 (37%), Gaps = 90/405 (22%)
Query: 87 RAARAIQGAFRQLRARRELARRREERREYLEQMETPQKEAYLAPVRREQEAARRLREQEE 146
R + + A L +R+L E+++ +Q+ +K A L V + A RE+E
Sbjct: 1482 RLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREA 1541
Query: 147 AA---------QRERREELQRRRRLLDAAFDG------DVG------------------E 173
A ++E REEL+R+ R L A + DVG +
Sbjct: 1542 RALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAAND 1601
Query: 174 IRAVLKEVEQLLT---------------------REGVGHDEAGEARR--LQRRVALAEC 210
+RA + E+E LT R+ G DEAGE RR L +++ AE
Sbjct: 1602 LRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEV 1661
Query: 211 EDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKL 270
E + A A + L +L EL A S G G AV+ L K+
Sbjct: 1662 ERDEERKQRTLAVAARKKLEGELE-ELKAQMASAGQ------------GKEEAVKQLRKM 1708
Query: 271 GADP----RVYAEDGSTPERVASLDTVVSVLRSWDLSLTEAMLQNMEAEQQRRAQEAQRH 326
A R E ++ E + S + S R L LQ A R ++AQ+
Sbjct: 1709 QAQMKELWREVEETRTSREEIFSQNR-ESEKRLKGLEAEVLRLQEELAASDRARRQAQQD 1767
Query: 327 KEAEAERM---TLKVQQLTREQQQCHKELQQAYCELSRRISEHDQCEWRCMDKTKLTLQA 383
++ A+ + L + E++Q L Q EL S + D+ + L
Sbjct: 1768 RDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLN----DRYRKLLLQ 1823
Query: 384 IKDTEAQVDRLRQEAQKAEEALAMARLELREQTQE-----GEEEA 423
++ ++ R + KAE R +L Q QE GEE+A
Sbjct: 1824 VESLTTELSAERSFSAKAES----GRQQLERQIQELRGRLGEEDA 1864
Score = 40.4 bits (93), Expect = 0.005
Identities = 81/378 (21%), Positives = 147/378 (38%), Gaps = 48/378 (12%)
Query: 80 ESRPAEDRAARAIQGAFRQLRARRELARRREERREYLEQMETPQKEAYLAPVRREQEAAR 139
E + EDR A A + + L + R + + ME ++ R+E E +
Sbjct: 1058 ERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKG--RQELEKLK 1115
Query: 140 RLREQEEAAQRERREELQRRRRLLDAAFDGDVGEIRAVLKEVEQLLTREGVGHDEAGEAR 199
R + E + +E+ E Q+R L A E++A L E DE G
Sbjct: 1116 RRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAE----------DEGGARA 1165
Query: 200 RL-----QRRVALAECEDSYGNTPLSEAAAGGQ--PLAIQLRAELGASPNSKGAFGPTPL 252
+L + + ALAE ++ + ++ A Q L +L A G ++ +
Sbjct: 1166 QLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQE 1225
Query: 253 YRAAFGGHLAAVEVLLKLGADPRVY---------AEDGSTPERVASLDTVVSVLRSWDLS 303
R+ E+ L + R++ + E L+ +W+ +
Sbjct: 1226 LRSK--REQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKT 1283
Query: 304 --LTEAMLQNMEAEQQRRAQEAQRHKEAEAERMTLKVQQL-------TREQQQCHKELQQ 354
EA + + AE Q A++ E R+ L++Q++ R + + ++LQ+
Sbjct: 1284 RLALEAEVSELRAELS-SLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQR 1342
Query: 355 AYCELSRRISEHDQCEWRCMDKTKLTLQAIKDTEAQVDRLRQEAQKAEEALAMARLELRE 414
A EL ++ E KT + + TEAQ+ +AQ+ + A+L L
Sbjct: 1343 AQAELENVSGALNEAE----SKTIRLSKELSSTEAQL----HDAQELLQEETRAKLALGS 1394
Query: 415 QTQEGEEEAPGLKCQVTE 432
+ + E EA GL+ Q+ E
Sbjct: 1395 RVRAMEAEAAGLREQLEE 1412
Score = 40.0 bits (92), Expect = 0.006
Identities = 48/193 (24%), Positives = 90/193 (46%), Gaps = 33/193 (17%)
Query: 269 KLGADPRVYAEDGSTPERVAS----LDTVVSVLRSWDLSLTEAMLQNMEAEQQR---RAQ 321
+L A+ + AE T R+A+ L+ VVS L + + E + M+ E++R Q
Sbjct: 953 QLRAEAELCAEAEETRGRLAARKQELELVVSELEA-RVGEEEECSRQMQTEKKRLQQHIQ 1011
Query: 322 EAQRHKEAE-AERMTLKVQQLTREQQQC-------------------HKELQQAYCELSR 361
E + H EAE R L+++++T E + K L+ E S
Sbjct: 1012 ELEAHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSS 1071
Query: 362 RISEHDQCEWRCMDKTKLTLQA----IKDTEAQVDRLRQEAQKAEEALAMARLELREQTQ 417
+ +E ++ + + ++K +L +A ++D + ++ RQE +K + L EL+EQ
Sbjct: 1072 QAAEEEE-KVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMV 1130
Query: 418 EGEEEAPGLKCQV 430
E ++ A L+ Q+
Sbjct: 1131 EQQQRAEELRAQL 1143
Score = 38.9 bits (89), Expect = 0.013
Identities = 88/406 (21%), Positives = 161/406 (39%), Gaps = 58/406 (14%)
Query: 86 DRAARAIQGAFRQLRAR-----RELARRREERREY---LEQMETPQKEAYLAPVRREQEA 137
+RA R + A LRA+ EL + + ++ ++T + +E
Sbjct: 1589 ERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEER 1648
Query: 138 ARRLREQEEAAQRERREELQRRRRLLDAAFDGDVGEIRAVLKEVEQLLTREGVGHDEA-- 195
R+L +Q A+ ER EE +++R L AA GE L+E++ + G G +EA
Sbjct: 1649 RRQLAKQLRDAEVERDEE-RKQRTLAVAARKKLEGE----LEELKAQMASAGQGKEEAVK 1703
Query: 196 ------GEARRLQRRVALAEC--EDSYGNTPLSEAAAGG-QPLAIQLRAELGASPNSK-- 244
+ + L R V E+ + SE G + ++L+ EL AS ++
Sbjct: 1704 QLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQ 1763
Query: 245 GAFGPTPLYRAAFGGHLAAVEVLL-------KLGADPRVYAEDGSTPE-----------R 286
+ G+L+ +L +LG E+ S E +
Sbjct: 1764 AQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQ 1823
Query: 287 VASLDTVVSVLRSWDLSLTEAMLQNMEAEQQRRAQEAQ-------RHK------EAEAER 333
V SL T +S RS+ Q Q+ R + + RHK E++ +
Sbjct: 1824 VESLTTELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARARHKMTIAALESKLAQ 1883
Query: 334 MTLKVQQLTREQQQCHKELQQAYCELSRRISEHDQCEWRCMDKTKLTLQAIKDTEAQVDR 393
+++Q TRE+ K +++A L + + ++ E R D+ + L+ Q+ R
Sbjct: 1884 AEEQLEQETRERILSGKLVRRAEKRLKEVVLQVEE-ERRVADQLRDQLEKGNLRVKQLKR 1942
Query: 394 LRQEAQKAEEALAMARLELREQTQEGEEEAPGLKCQVTELHDVLMK 439
+EA++ R L+ + ++ E A + +VT L + L +
Sbjct: 1943 QLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRLRR 1988
Score = 35.8 bits (81), Expect = 0.11
Identities = 29/115 (25%), Positives = 53/115 (46%), Gaps = 14/115 (12%)
Query: 306 EAMLQNMEAEQQRRAQEAQRHKEAEAERMTLKVQQLTREQQQCHKELQQAYCELSRRISE 365
+ + +E E+ R A++ + E AE + + R+Q EL+ EL R+ E
Sbjct: 937 QGRVAQLEEERARLAEQLRAEAELCAEAEETRGRLAARKQ-----ELELVVSELEARVGE 991
Query: 366 HDQCEWRCMDKTKLTLQAIKDTEAQVDRLRQEAQKAEEALAMARLELREQTQEGE 420
++C + + K Q I++ EA ++ AEE A +L+L + T E +
Sbjct: 992 EEECSRQMQTEKKRLQQHIQELEAHLE--------AEEG-ARQKLQLEKVTTEAK 1037
>gi|22208951 ankyrin repeat and SOCS box-containing protein 3
isoform b [Homo sapiens]
Length = 445
Score = 58.5 bits (140), Expect = 2e-08
Identities = 33/82 (40%), Positives = 46/82 (56%)
Query: 201 LQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGH 260
L R+ A EC+D +G TPL AA G+ ++ + GA+ N + TPL+ AA GH
Sbjct: 92 LLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGH 151
Query: 261 LAAVEVLLKLGADPRVYAEDGS 282
VE+LL GADP +Y + S
Sbjct: 152 TKCVELLLSSGADPDLYCNEDS 173
Score = 36.2 bits (82), Expect = 0.085
Identities = 21/59 (35%), Positives = 33/59 (55%)
Query: 231 IQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVAS 289
I+L GA+ + FG TPL+ AA G L ++ +L+ GA+ A D +TP +A+
Sbjct: 89 IKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAA 147
Score = 35.8 bits (81), Expect = 0.11
Identities = 21/69 (30%), Positives = 29/69 (42%)
Query: 210 CEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLK 269
C + P+ AA G + L L G +P+Y A FGGH +E+LL+
Sbjct: 169 CNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLR 228
Query: 270 LGADPRVYA 278
G P A
Sbjct: 229 NGYSPDAQA 237
Score = 33.5 bits (75), Expect = 0.55
Identities = 20/59 (33%), Positives = 30/59 (50%)
Query: 215 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGAD 273
G L AA+ G +Q+ E GA PN+ TPL+ A G + + +LL+ GA+
Sbjct: 6 GFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGAN 64
Score = 33.1 bits (74), Expect = 0.72
Identities = 24/74 (32%), Positives = 39/74 (52%), Gaps = 1/74 (1%)
Query: 217 TPLSEAAAGGQPLAIQLRAELGASPN-SKGAFGPTPLYRAAFGGHLAAVEVLLKLGADPR 275
TPL A GQ ++L + GA+ N S G L++A+F + +++LL+ GA+
Sbjct: 41 TPLFLAVENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKE 100
Query: 276 VYAEDGSTPERVAS 289
+ G TP VA+
Sbjct: 101 CQDDFGITPLFVAA 114
Score = 32.7 bits (73), Expect = 0.94
Identities = 18/47 (38%), Positives = 27/47 (57%)
Query: 252 LYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVASLDTVVSVLR 298
L+ AA GH V++LL+ GADP + +TP +A + + VLR
Sbjct: 10 LHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLR 56
>gi|7705831 ankyrin repeat and SOCS box-containing protein 3 isoform
a [Homo sapiens]
Length = 518
Score = 58.5 bits (140), Expect = 2e-08
Identities = 33/82 (40%), Positives = 46/82 (56%)
Query: 201 LQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGH 260
L R+ A EC+D +G TPL AA G+ ++ + GA+ N + TPL+ AA GH
Sbjct: 165 LLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGH 224
Query: 261 LAAVEVLLKLGADPRVYAEDGS 282
VE+LL GADP +Y + S
Sbjct: 225 TKCVELLLSSGADPDLYCNEDS 246
Score = 41.2 bits (95), Expect = 0.003
Identities = 31/103 (30%), Positives = 49/103 (47%), Gaps = 3/103 (2%)
Query: 199 RRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPN---SKGAFGPTPLYRA 255
R+L ++ + D+ G P+ EAA +Q+ +S N K G L+ A
Sbjct: 27 RKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMKTFEGFCALHLA 86
Query: 256 AFGGHLAAVEVLLKLGADPRVYAEDGSTPERVASLDTVVSVLR 298
A GH V++LL+ GADP + +TP +A + + VLR
Sbjct: 87 ASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLR 129
Score = 36.2 bits (82), Expect = 0.085
Identities = 21/59 (35%), Positives = 33/59 (55%)
Query: 231 IQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVAS 289
I+L GA+ + FG TPL+ AA G L ++ +L+ GA+ A D +TP +A+
Sbjct: 162 IKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAA 220
Score = 35.8 bits (81), Expect = 0.11
Identities = 21/69 (30%), Positives = 29/69 (42%)
Query: 210 CEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLK 269
C + P+ AA G + L L G +P+Y A FGGH +E+LL+
Sbjct: 242 CNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLR 301
Query: 270 LGADPRVYA 278
G P A
Sbjct: 302 NGYSPDAQA 310
Score = 34.7 bits (78), Expect = 0.25
Identities = 32/121 (26%), Positives = 54/121 (44%), Gaps = 12/121 (9%)
Query: 165 AAFDGDVGEIRAVLKEVEQLLTREGVGHDEAGEAR-----RLQRRVALAECEDSY----- 214
AA +G+V +R +LK+ + + G EA + + A+ ++Y
Sbjct: 17 AAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMKT 76
Query: 215 --GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGA 272
G L AA+ G +Q+ E GA PN+ TPL+ A G + + +LL+ GA
Sbjct: 77 FEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGA 136
Query: 273 D 273
+
Sbjct: 137 N 137
Score = 33.1 bits (74), Expect = 0.72
Identities = 24/74 (32%), Positives = 39/74 (52%), Gaps = 1/74 (1%)
Query: 217 TPLSEAAAGGQPLAIQLRAELGASPN-SKGAFGPTPLYRAAFGGHLAAVEVLLKLGADPR 275
TPL A GQ ++L + GA+ N S G L++A+F + +++LL+ GA+
Sbjct: 114 TPLFLAVENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKE 173
Query: 276 VYAEDGSTPERVAS 289
+ G TP VA+
Sbjct: 174 CQDDFGITPLFVAA 187
>gi|157738667 FYVE and coiled-coil domain containing 1 [Homo
sapiens]
Length = 1478
Score = 57.0 bits (136), Expect = 5e-08
Identities = 81/323 (25%), Positives = 128/323 (39%), Gaps = 45/323 (13%)
Query: 128 LAPVRREQEAARRLREQEEA---AQRERREELQRRRRLLDAAFDGDVGEIRAVLKEVEQL 184
LA + EQ + R L +Q EA A R+ +E ++ + +A GE + + +EVEQ
Sbjct: 660 LASLEAEQASIRHLGDQMEASLLAVRKAKEAMKAQMAEKEAILQSKEGECQQLREEVEQC 719
Query: 185 LTREGVGHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPL-------AIQLRAEL 237
+ EAR + R ++C+ + A G Q + A +L A+L
Sbjct: 720 --------QQLAEARHRELRALESQCQQQTQLIEVLTAEKGQQGVGPPTDNEARELAAQL 771
Query: 238 GASPNSKGAFGPTPLYRAAFGGHLAAVEVL----LKLGADPRVYAEDGSTPERVASLDTV 293
S +A H V+ L + L A R +D + + L
Sbjct: 772 ALS-------------QAQLEVHQGEVQRLQAQVVDLQAKMRAALDDQDKVQ--SQLSMA 816
Query: 294 VSVLRSWDLSLTEAMLQNMEAEQQRRAQEAQRHKEAEA---ERMTLKVQQLTREQQQCHK 350
+VLR +L + + + EA + QE + E E E + QQ E + +
Sbjct: 817 EAVLREHK-TLVQQLKEQNEALNRAHVQELLQCSEREGALQEERADEAQQREEELRALQE 875
Query: 351 ELQQAYCELSRRISEHDQCEWRCMDKTKLTLQAIKDTEAQVDRLRQEAQKAEEALAMARL 410
EL QA C EH + + + T + QV L E ++ EEALA A
Sbjct: 876 ELSQAKCSSEEAQLEHAELQEQLHRANTDTAEL----GIQVCALTVEKERVEEALACAVQ 931
Query: 411 ELREQTQEGEEEAPGLKCQVTEL 433
EL++ + E GL+ QV L
Sbjct: 932 ELQDAKEAASREREGLERQVAGL 954
Score = 37.4 bits (85), Expect = 0.038
Identities = 66/332 (19%), Positives = 137/332 (41%), Gaps = 41/332 (12%)
Query: 110 EERREYLEQMETPQKEAYLAPVRREQEAARRLREQEEAAQRERREELQRRRRLLDAAFDG 169
+E R L+Q+E +K+ +R + R ++ AA ++ E+LQ R A +
Sbjct: 233 DEMRLELDQLEVREKQ-----LRERMQQLDRENQELRAAVSQQGEQLQTERERGRTAAED 287
Query: 170 DVGEIRAVLKEVEQLLTREGVGHDEAGEARRLQRRVAL--AECEDSYGNTPLSEAAAGGQ 227
+V + ++ E+++ + E + + + L AE E+ Y +T L + Q
Sbjct: 288 NV-RLTCLVAELQKQWEVTQATQNTVKELQTCLQGLELGAAEKEEDY-HTALRRLESMLQ 345
Query: 228 PLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADPR---------VYA 278
PLA +L A ++ + + A+F G LA + +D +
Sbjct: 346 PLAQELEA-------TRDSLDKKNQHLASFPGWLAMAQQKADTASDTKGRQEPIPSDAAQ 398
Query: 279 EDGSTPERVASLD---TVVSVLRSWDLSLTEAMLQNMEAEQQRRA------------QEA 323
E E++ +L+ T V + + E +++ ++ ++ RA QE
Sbjct: 399 EMQELGEKLQALERERTKVEEVNRQQSAQLEQLVKELQLKEDARASLERLVKEMAPLQEE 458
Query: 324 QRHKEAEAERMTLKVQQLTREQQQCHKELQQAYCELSRRISEHDQCEWRCMDKTKLTLQA 383
K EA+++ ++Q+L +EL + E ++ E + E T+ LQ
Sbjct: 459 LSGKGQEADQLWRRLQELLAHTSSWEEELAELRREKKQQQEEKELLEQEVRSLTR-QLQF 517
Query: 384 IKDTEAQVDRLRQEAQKAEEALAMARLELREQ 415
++ AQV + + ++ ++ L + L +Q
Sbjct: 518 LETQLAQVSQHVSDLEEQKKQLIQDKDHLSQQ 549
Score = 30.4 bits (67), Expect = 4.7
Identities = 70/331 (21%), Positives = 133/331 (40%), Gaps = 26/331 (7%)
Query: 109 REERREYLEQMETPQKEAYLAPVRREQEAARRLREQEEAAQRERREELQRRRRLLDAAFD 168
+EER + E Q+E L ++ E A+ E+ + E +E+L R D A
Sbjct: 856 QEERAD-----EAQQREEELRALQEELSQAKCSSEEAQLEHAELQEQLHRAN--TDTAEL 908
Query: 169 G-DVGEIRAVLKEVEQLL---TREGVGHDEAGEARR--LQRRVA--LAECEDSYGNTPLS 220
G V + + VE+ L +E EA R L+R+VA E E +
Sbjct: 909 GIQVCALTVEKERVEEALACAVQELQDAKEAASREREGLERQVAGLQQEKESLQEKLKAA 968
Query: 221 EAAAGGQP-LAIQL-RAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADPRVYA 278
+AAAG P L QL +AE A + A + + + LK A +
Sbjct: 969 KAAAGSLPGLQAQLAQAEQRAQSLQEAAHQELNTLKFQLSAEIMDYQSRLK-NAGEECKS 1027
Query: 279 EDGSTPE---RVASLDTVVSVLRSWDLSLTEAMLQNMEAEQQRRAQEAQRHKEAEAERMT 335
G E ++ + + V L++ + E + + + Q A K+ E +
Sbjct: 1028 LRGQLEEQGRQLQAAEEAVEKLKATQADMGEKL--SCTSNHLAECQAAMLRKDKEGAALR 1085
Query: 336 LKVQQLTREQQQCHKELQQAYCELSRRIS---EHDQCEWRCMDKTKLTLQAIKDTEAQVD 392
+++ +E ++ ++Q+ Y +L + ++ +DQ +D T + +++ ++
Sbjct: 1086 EDLERTQKELEKATTKIQEYYNKLCQEVTNRERNDQKMLADLDDLNRTKKYLEERLIELL 1145
Query: 393 RLRQEAQKAEEALAMARLELREQTQEGEEEA 423
R + + +AL + E+ G+ EA
Sbjct: 1146 RDKDALWQKSDALEFQQKLSAEERWLGDTEA 1176
>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
Length = 4377
Score = 56.6 bits (135), Expect = 6e-08
Identities = 42/110 (38%), Positives = 54/110 (49%), Gaps = 5/110 (4%)
Query: 191 GHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPT 250
GH E L +R A + GNT L A+ GQ +++ GA+ N++ G T
Sbjct: 85 GHVEV--VSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFT 142
Query: 251 PLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVA---SLDTVVSVL 297
PLY AA HL V+ LL GA + EDG TP VA D VVS+L
Sbjct: 143 PLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLL 192
Score = 44.7 bits (104), Expect = 2e-04
Identities = 28/75 (37%), Positives = 39/75 (52%)
Query: 215 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADP 274
G TPL AA G+ L + ASP++ G G TPL+ AA + +LL GA P
Sbjct: 565 GFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASP 624
Query: 275 RVYAEDGSTPERVAS 289
A++G TP +A+
Sbjct: 625 HAAAKNGYTPLHIAA 639
Score = 44.7 bits (104), Expect = 2e-04
Identities = 33/126 (26%), Positives = 52/126 (41%)
Query: 193 DEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPL 252
D A L + A + + G TPL G + + A N+K G TPL
Sbjct: 708 DRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPL 767
Query: 253 YRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVASLDTVVSVLRSWDLSLTEAMLQNM 312
++AA GH + VLL+ A P +G+T +A +SV+ + + E M
Sbjct: 768 HQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIARRLGYISVVDTLKIVTEETMTTTT 827
Query: 313 EAEQQR 318
E+ +
Sbjct: 828 VTEKHK 833
Score = 44.3 bits (103), Expect = 3e-04
Identities = 32/96 (33%), Positives = 45/96 (46%)
Query: 194 EAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLY 253
+A R L + A E + TPL +A G+ +Q + GASPN+ G TPL+
Sbjct: 478 QAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLH 537
Query: 254 RAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVAS 289
+A GH LL GA + + G TP VA+
Sbjct: 538 LSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAA 573
Score = 42.4 bits (98), Expect = 0.001
Identities = 31/97 (31%), Positives = 48/97 (49%), Gaps = 1/97 (1%)
Query: 201 LQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGH 260
LQ V + + + Y T L AA G ++ + A+PN+K G TPL+ A
Sbjct: 354 LQHNVPVDDVTNDY-LTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNR 412
Query: 261 LAAVEVLLKLGADPRVYAEDGSTPERVASLDTVVSVL 297
+ +E+LLK GA + E G TP VA+ V+++
Sbjct: 413 IKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIV 449
Score = 40.8 bits (94), Expect = 0.003
Identities = 25/75 (33%), Positives = 35/75 (46%)
Query: 215 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADP 274
G TP+ AA G + GASPN+ G T L+ AA G V L++ GA
Sbjct: 433 GLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQV 492
Query: 275 RVYAEDGSTPERVAS 289
A+D TP +++
Sbjct: 493 EAKAKDDQTPLHISA 507
Score = 38.5 bits (88), Expect = 0.017
Identities = 27/84 (32%), Positives = 39/84 (46%)
Query: 215 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADP 274
G TPL A + ++L + GAS + G TP++ AAF GH+ V L+ GA P
Sbjct: 400 GFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASP 459
Query: 275 RVYAEDGSTPERVASLDTVVSVLR 298
G T +A+ V+R
Sbjct: 460 NTTNVRGETALHMAARSGQAEVVR 483
Score = 38.1 bits (87), Expect = 0.022
Identities = 24/70 (34%), Positives = 32/70 (45%)
Query: 215 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADP 274
G T L AA GQ ++ + GA +K TPL+ +A G V+ LL+ GA P
Sbjct: 466 GETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASP 525
Query: 275 RVYAEDGSTP 284
G TP
Sbjct: 526 NAATTSGYTP 535
Score = 37.4 bits (85), Expect = 0.038
Identities = 28/92 (30%), Positives = 42/92 (45%)
Query: 198 ARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAF 257
A L R A + TPL A+ G ++L + GA ++K G TPL+ A
Sbjct: 251 ATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGAR 310
Query: 258 GGHLAAVEVLLKLGADPRVYAEDGSTPERVAS 289
GH VE+LL A ++G +P +A+
Sbjct: 311 SGHEQVVEMLLDRAAPILSKTKNGLSPLHMAT 342
Score = 37.4 bits (85), Expect = 0.038
Identities = 32/118 (27%), Positives = 47/118 (39%), Gaps = 16/118 (13%)
Query: 180 EVEQLLTREGVGHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGA 239
EV LL ++ D AG++ G TPL AA L + GA
Sbjct: 579 EVANLLLQKSASPDAAGKS----------------GLTPLHVAAHYDNQKVALLLLDQGA 622
Query: 240 SPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVASLDTVVSVL 297
SP++ G TPL+ AA + LL+ GAD G +A+ + V ++
Sbjct: 623 SPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMV 680
Score = 36.6 bits (83), Expect = 0.065
Identities = 29/96 (30%), Positives = 43/96 (44%)
Query: 194 EAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLY 253
+A ++L ++ A + G TPL +A G + GAS + G TPL+
Sbjct: 511 KADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLH 570
Query: 254 RAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVAS 289
AA G L +LL+ A P + G TP VA+
Sbjct: 571 VAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAA 606
Score = 33.5 bits (75), Expect = 0.55
Identities = 23/75 (30%), Positives = 35/75 (46%)
Query: 195 AGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYR 254
A + L R A + + G TPL A G +++ + A SK G +PL+
Sbjct: 281 ANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHM 340
Query: 255 AAFGGHLAAVEVLLK 269
A G HL V++LL+
Sbjct: 341 ATQGDHLNCVQLLLQ 355
Score = 31.2 bits (69), Expect = 2.7
Identities = 29/107 (27%), Positives = 45/107 (42%), Gaps = 7/107 (6%)
Query: 185 LTREGVG--HDEAGEAR-----RLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAEL 237
+TR+G+ H A E L R A + G TPL AA + ++
Sbjct: 660 VTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQ 719
Query: 238 GASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTP 284
GA +++ G TPL+ G++ V LL+ A ++G TP
Sbjct: 720 GAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTP 766
>gi|56676397 ankyrin repeat domain 11 [Homo sapiens]
Length = 2663
Score = 56.6 bits (135), Expect = 6e-08
Identities = 41/106 (38%), Positives = 59/106 (55%), Gaps = 5/106 (4%)
Query: 196 GEARRLQRRV---ALAECEDSYGNTPLSEAAAGGQ-PLAIQLRAELGASPNSKGAFGPTP 251
G+ARR++ + A +D G T L EA G +A QL A GA N+KG TP
Sbjct: 179 GDARRIKELISEGADVNVKDFAGWTALHEACNRGYYDVAKQLLAA-GAEVNTKGLDDDTP 237
Query: 252 LYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVASLDTVVSVL 297
L+ AA GH V++LL+ G +P+ G TP +VA+ T+V++L
Sbjct: 238 LHDAANNGHYKVVKLLLRYGGNPQQSNRKGETPLKVANSPTMVNLL 283
>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
Length = 2017
Score = 56.2 bits (134), Expect = 8e-08
Identities = 82/367 (22%), Positives = 151/367 (41%), Gaps = 35/367 (9%)
Query: 91 AIQGAFRQLRARRELARRREERREYLEQMETPQKEAYLAPVRREQEAARRLREQEEAAQR 150
A+QG RQ +AR +ER E L + ++ +R ++A L EQ+ R
Sbjct: 768 ALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEAL-EQQLPTLR 826
Query: 151 ERREELQRRRRLLDAAFDGDVGEIRAVLKEVEQLL--------TREGVGHDEAGEARRLQ 202
R +LQ + L G E+ +E ++ + +E + + AG A +L
Sbjct: 827 HERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQL- 885
Query: 203 RRVALAECE-----DSYGNTPLSEAAAGGQPLAIQLR-AELGASPNSKGAFGPTPLY-RA 255
AE E + L + A G +Q + A+L A A G L +
Sbjct: 886 ---VAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKE 942
Query: 256 AFGGHLAAVEVLLKLGADPRVYAEDGSTPERVASLDTVVSVLRSWDLSLTEAMLQNMEAE 315
G LA + + + ++ ++ ++ +V R SL E + E
Sbjct: 943 TLTGELAGLRQQI-------IATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDL 995
Query: 316 QQRRAQEAQRHKEAEAERMTLKVQQLTREQQQCHKELQQAYCELSRRIS--EHDQCEWRC 373
Q+ + ++ +E EAER L+ QL REQ++ L+ ELS I+ + ++ E
Sbjct: 996 QRLQREKEAAWRELEAERAQLQ-SQLQREQEELLARLEAEKEELSEEIAALQQERDEGLL 1054
Query: 374 MDKTKLTLQAIKDTEAQVDRLRQEAQKAEEALAMARLELREQTQEG----EEEAPGLKCQ 429
+ +++ QA+ E++ L ++ +LA LE+ Q ++ E++ +
Sbjct: 1055 LAESE-KQQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNAL 1113
Query: 430 VTELHDV 436
+EL D+
Sbjct: 1114 TSELRDL 1120
Score = 55.5 bits (132), Expect = 1e-07
Identities = 94/358 (26%), Positives = 147/358 (41%), Gaps = 39/358 (10%)
Query: 80 ESRPAEDRAA-RAIQGAFRQLRARRELARRREERREYLEQMETPQKEAYLAPVRREQEAA 138
+SR +DR+ A+ R LRA+RE A A+ VRR QE A
Sbjct: 1100 QSRQEQDRSTVNALTSELRDLRAQREEAAA-----------------AHAQEVRRLQEQA 1142
Query: 139 RRLREQEEAAQRERREELQRRRRLLDAAFDGDVGEIRAVLKEVEQLLTREGVGHDEAGEA 198
R L +Q ++ RE EEL+ + RLL+ A DG E+ +++ + V EAGE
Sbjct: 1143 RDLGKQRDSCLREA-EELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAGEL 1201
Query: 199 RRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFG 258
RR A N L A + I L+ A+ + + R A G
Sbjct: 1202 RRSLGEGAKEREALRRSNEELRSAVKKAESERISLKL---ANEDKEQKLALLEEARTAVG 1258
Query: 259 GHLAAVEVLLKLGADPRVYAEDGSTPERVASLDTVVSVLRSWDLSLTEAMLQNMEAEQQR 318
+ L+ R+ A + L + +L S + L + AE Q
Sbjct: 1259 KEAGELRTGLQEVERSRLEAR-----RELQELRRQMKMLDSENTRLGREL-----AELQG 1308
Query: 319 RAQEAQRHKEAEAERMTLKVQQLTREQQQCHKELQQAYCELSRRISEHDQCEWRCMDKTK 378
R +R E E+ R TL ++Q + + + ++Q R++ E + E+R ++
Sbjct: 1309 RLALGER-AEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEG-EFRTRERRL 1366
Query: 379 L-TLQAIKDTE-AQVDRLRQEAQKAEEALA-MARLELREQTQEGEEEAPGLKCQVTEL 433
L +L+ + TE Q+D R K E A A A L LR EG A GL+ ++ +
Sbjct: 1367 LGSLEEARGTEKQQLDHARGLELKLEAARAEAAELGLRLSAAEG--RAQGLEAELARV 1422
Score = 49.7 bits (117), Expect = 7e-06
Identities = 96/374 (25%), Positives = 147/374 (39%), Gaps = 67/374 (17%)
Query: 82 RPAEDRAARAIQGAFRQ---LRARRELARRREERREYLEQMETPQKEAYLAPVRREQEAA 138
R D A +A + A R+ LR+ EL R E+ ++ Q++A E
Sbjct: 574 RDKTDGAMQAHEDAQREVQRLRSANELLSR--EKSNLAHSLQVAQQQA---------EEL 622
Query: 139 RRLREQEEAAQRERREELQR-RRRLLDAAFDGD--VGEIRAVLKEVEQLLTREGVGHDEA 195
R+ RE+ +AAQ E R + R DA DG E+ +++EQL + V E
Sbjct: 623 RQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKEL 682
Query: 196 GEARRLQRRVAL----AECEDSYGNTPLSEAAAGGQPLAI---QLRAELGASPNSKGAFG 248
E R R L + E + L++A AG L + +LRAE + +S
Sbjct: 683 VEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQDS----- 737
Query: 249 PTPLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPER-VASLDTVVSVL----RSWDLS 303
L KL A A+D R VA L+ S L R +
Sbjct: 738 ------------------LSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQE 779
Query: 304 LTEAMLQNMEAEQQRRAQEAQRHKEAEAERMTLKVQQLTREQ----QQCHKELQQAYCEL 359
T A + E+ R QE R + R+ + Q+ +Q + +LQ+ +L
Sbjct: 780 ATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQL 839
Query: 360 SRRISEHDQCEWRCMDKTKLTLQAIKDTEAQVDRLRQEAQKAEEALAMARLELREQTQEG 419
SR++S +Q QA ++ + QV+ L + A + +EALA L Q
Sbjct: 840 SRQLSGREQ----------ELEQARREAQRQVEAL-ERAAREKEALAKEHAGLAVQLVAA 888
Query: 420 EEEAPGLKCQVTEL 433
E E L + T L
Sbjct: 889 EREGRTLSEEATRL 902
Score = 47.4 bits (111), Expect = 4e-05
Identities = 99/441 (22%), Positives = 165/441 (37%), Gaps = 67/441 (15%)
Query: 70 EPRLGRAGGFESRPAEDRAARAIQGAFRQLRARR--------ELARRREERREYLEQM-- 119
E + R G S ++A A++ LR R +L+R+ R + LEQ
Sbjct: 796 EQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARR 855
Query: 120 ETPQKEAYLAPVRREQEAARR----LREQEEAAQRERR--EELQRRRRLLDAAFDGDVGE 173
E ++ L RE+EA + L Q AA+RE R E R RL A +G + E
Sbjct: 856 EAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFE 915
Query: 174 IRAVLKEVEQ------------LLTREGVGHDEAGEARRLQRRVALAECEDSYGNTPLSE 221
++ L ++E LL +E + + AG +++ A + L +
Sbjct: 916 VQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQ 975
Query: 222 AAAGGQPLAIQLRA----ELGASPNSK-GAFGPTPLYRAAFGGHLAAV--EVLLKLGADP 274
A Q + RA +L K A+ RA L E+L +L A+
Sbjct: 976 AEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQEELLARLEAEK 1035
Query: 275 RVYAED---------------GSTPERVASLDTVVSVLRSWDLSLTEAMLQNMEAEQQRR 319
+E+ S ++ SL S L T L + E +R+
Sbjct: 1036 EELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQ 1095
Query: 320 AQEAQRHKEAEAERMTLKVQQLTREQQQCHKELQQAYCELSRRISEH--------DQCEW 371
++AQ +E + + +L R+ + +E A+ + RR+ E D C
Sbjct: 1096 KRDAQSRQEQDRSTVNALTSEL-RDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSC-L 1153
Query: 372 RCMDKTKLTLQAIKDTE-------AQVDRLRQEAQKAEEALAMARLELREQTQEGEEEAP 424
R ++ + L+ ++D + R +E+Q+ E ELR EG +E
Sbjct: 1154 REAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAGELRRSLGEGAKERE 1213
Query: 425 GLKCQVTELHDVLMKDVGNRI 445
L+ EL + K RI
Sbjct: 1214 ALRRSNEELRSAVKKAESERI 1234
Score = 45.1 bits (105), Expect = 2e-04
Identities = 90/358 (25%), Positives = 144/358 (40%), Gaps = 81/358 (22%)
Query: 87 RAARAIQGAFRQLRARRELARRREERREYLEQMETPQKEAYLAPVRREQEAARRLREQEE 146
R +RA+Q A L LA R E +K+A L EQ + LRE++
Sbjct: 330 RTSRAVQEAGLGLSTGLRLAESRAEA--------ALEKQALLQAQLEEQLRDKVLREKD- 380
Query: 147 AAQRERREELQRRRRLLDAAFDGDVGEIRAVLKEVE-QLLTREGVGHD-----EAGEARR 200
AQ++ + +L + A V E+ +K +E Q L ++ V D EA E+ R
Sbjct: 381 LAQQQMQSDLDK------ADLSARVTELGLAVKRLEKQNLEKDQVNKDLTEKLEALESLR 434
Query: 201 LQRRVALAECEDSYG---------NTPLSEAAAGGQPLAIQLRAEL--GASPNSKGAFGP 249
LQ + AL E ED G LS++ +G Q + A+ G+ G P
Sbjct: 435 LQEQAAL-ETEDGEGLQQTLRDLAQAVLSDSESGVQLSGSERTADASNGSLRGLSGQRTP 493
Query: 250 TPLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVASLDTVVSVLRSWDLSLTEAML 309
+P R++ G G PR G +P A D S T A++
Sbjct: 494 SPPRRSSPGR-----------GRSPR----RGPSP---ACSD-----------SSTLALI 524
Query: 310 QNMEAEQQRRAQEAQRHKEAEAERMTLKVQQLTREQQQCHKELQQAYCELSRRISEHDQC 369
+ ++Q + Q+ + EA + + +QL+ + + R + E Q
Sbjct: 525 HSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSESE------------RRALEEQLQ- 571
Query: 370 EWRCMDKTKLTLQAIKDTEAQVDRLRQEAQKAEEALAMARLELREQTQEGEEEAPGLK 427
R DKT +QA +D + +V RLR A E L+ + L Q +++A L+
Sbjct: 572 --RLRDKTDGAMQAHEDAQREVQRLR----SANELLSREKSNLAHSLQVAQQQAEELR 623
Score = 34.7 bits (78), Expect = 0.25
Identities = 105/469 (22%), Positives = 180/469 (38%), Gaps = 63/469 (13%)
Query: 28 ELRARRGSQDPRRRGAGEVPADLGPLR--VPGSRAASSCGLCGREPRLGRAGGFESRPAE 85
E+ A R S R R + A+ R V G + L +E + R+ E R
Sbjct: 1541 EMEAERDSATSRARQLQKAVAESEEARRSVDGRLSGVQAELALQEESVRRSER-ERRATL 1599
Query: 86 DRAA---RAIQGAFRQLRARRELARRREERREYLEQMETPQKEAYLAPVRR--EQEAARR 140
D+ A R++Q +LRA +E + + LE + KE A R + E RR
Sbjct: 1600 DQVATLERSLQATESELRASQEKISKMKANETKLEGDKRRLKEVLDASESRTVKLELQRR 1659
Query: 141 L--------------REQEEAAQRERREELQRR---------------RRLLDAA--FDG 169
RE + A ++R + LQR+ RL A +
Sbjct: 1660 SLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEE 1719
Query: 170 DVGEIRAVLKEVEQLLTREGVGHDEAGEARRLQRRVALAECE-DSYGNTPLSEAAAGGQP 228
G +R ++ + + L + + + + L + AL CE D +AA
Sbjct: 1720 SEGALRDKVRGLTEALAQSSASLNSTRD-KNLHLQKALTACEHDRQVLQERLDAARQALS 1778
Query: 229 LAIQLRAELGASPNS-KGAFGPTPLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERV 287
A + + LG + +G L R G L + +L+ + A + V
Sbjct: 1779 EARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQEGEAAALN-----TV 1833
Query: 288 ASLDTVVSVLRSWDLSLTEAMLQNMEAEQQRRAQEAQR-HKEAEAERMTL-KVQQ----- 340
L +L+ SL A+ Q +EAE++ + A R K+ A R TL KV++
Sbjct: 1834 QKLQDERRLLQERLGSLQRALAQ-LEAEKREVERSALRLEKDRVALRRTLDKVEREKLRS 1892
Query: 341 ------LTREQQQCHKELQQAYCELSRRISEHDQCEWRC--MDKTKLTLQAIKDTEAQVD 392
L+ E+ + + L A EL+ + Q E + ++++ Q D + Q
Sbjct: 1893 HEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQQQQL 1952
Query: 393 RLRQEAQKAEEALAMARLELREQTQEGEEEAPGLKCQVTELHDVLMKDV 441
L+QE ++ A A L + + + GL+ QV+ L L +++
Sbjct: 1953 ELQQEVERLRSAQAQTERTLEARERAHRQRVRGLEEQVSTLKGQLQQEL 2001
Score = 30.8 bits (68), Expect = 3.6
Identities = 93/415 (22%), Positives = 164/415 (39%), Gaps = 92/415 (22%)
Query: 92 IQGAFRQLRARR-ELARRREERREYLEQ--------METPQKEAYLAPVRREQEAARRLR 142
++ Q RA R ELA + E LEQ +ET + VR+ E R+L+
Sbjct: 93 VEDLLAQSRAERDELAIKYNAVSERLEQALRLEPGELETQEPRGL---VRQSVELRRQLQ 149
Query: 143 EQEEAAQRERR--EELQRRRRLLDAAFDGDVGEIRAVLKEVEQ-LLTREG---------V 190
E++ + +R+ + +E Q+R+ L G + + + E+EQ LL R G
Sbjct: 150 EEQASYRRKLQAYQEGQQRQAQLVQRLQGKILQYKKRCSELEQQLLERSGELEQQRLRDT 209
Query: 191 GHDEAGEARRL------QRRVALAECEDSYGNTPLSEAAAGGQPLAIQLR---------- 234
H + E+ + QR +LA+ ++ L +A + Q L+ +R
Sbjct: 210 EHSQDLESALIRLEEEQQRSASLAQV-NAMLREQLDQAGSANQALSEDIRKVTNDWTRCR 268
Query: 235 -------AELGASPNSKGAFGPTP------LYRAAFGGHLAAVEV-------LLKLGADP 274
A S A+ L+R G EV LL+LG +
Sbjct: 269 KELEHREAAWRREEESFNAYFSNEHSRLLLLWRQVVGFRRLVSEVKMFTERDLLQLGGE- 327
Query: 275 RVYAEDGSTPERVASLDTVVSVLRSWDLSLTEAMLQNMEAEQQRRAQEAQRHKEAEAERM 334
+ + E L T + + S EA L+ +A Q + +E R K
Sbjct: 328 -LARTSRAVQEAGLGLSTGLRLAES----RAEAALEK-QALLQAQLEEQLRDK------- 374
Query: 335 TLKVQQLTREQQQCHKELQQAYCELSRRISEHDQCEWRCMDKTKLTLQAIKDTEAQVDRL 394
L+ + L QQQ +L +A +LS R++E L ++ ++ + D++
Sbjct: 375 VLREKDLA--QQQMQSDLDKA--DLSARVTE-----------LGLAVKRLEKQNLEKDQV 419
Query: 395 RQEAQKAEEALAMARLELREQTQEGEEEAPGLKCQVTELHDVLMKDVGNRIRADG 449
++ + EAL R L+EQ E+ GL+ + +L ++ D + ++ G
Sbjct: 420 NKDLTEKLEALESLR--LQEQAALETEDGEGLQQTLRDLAQAVLSDSESGVQLSG 472
>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
Length = 1881
Score = 56.2 bits (134), Expect = 8e-08
Identities = 35/88 (39%), Positives = 45/88 (51%)
Query: 201 LQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGH 260
L + + E GNT L AA GQ ++ GA+ N++ G TPLY AA H
Sbjct: 64 LLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENH 123
Query: 261 LAAVEVLLKLGADPRVYAEDGSTPERVA 288
L V+ LL+ GA+ V EDG TP VA
Sbjct: 124 LEVVKFLLENGANQNVATEDGFTPLAVA 151
Score = 53.5 bits (127), Expect = 5e-07
Identities = 40/109 (36%), Positives = 51/109 (46%), Gaps = 2/109 (1%)
Query: 191 GHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPT 250
GH E A L + A C G TPL AA G+ +L E A PN+ G G T
Sbjct: 514 GHVETVLA--LLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLT 571
Query: 251 PLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVASLDTVVSVLRS 299
PL+ A +L V++LL G P A +G TP +A+ V V RS
Sbjct: 572 PLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARS 620
Score = 50.1 bits (118), Expect = 6e-06
Identities = 30/73 (41%), Positives = 38/73 (52%)
Query: 217 TPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADPRV 276
TPL AA G ++ + GA PNS+ G TPL+ A H+ +E+LLK GA
Sbjct: 340 TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDA 399
Query: 277 YAEDGSTPERVAS 289
E G TP VAS
Sbjct: 400 VTESGLTPLHVAS 412
Score = 49.3 bits (116), Expect = 1e-05
Identities = 30/82 (36%), Positives = 43/82 (52%)
Query: 215 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADP 274
G TPL A+ G ++ + A N+K G +PL++AA GH V +LLK GA P
Sbjct: 701 GYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASP 760
Query: 275 RVYAEDGSTPERVASLDTVVSV 296
+ DG+TP +A +SV
Sbjct: 761 NEVSSDGTTPLAIAKRLGYISV 782
Score = 44.7 bits (104), Expect = 2e-04
Identities = 34/99 (34%), Positives = 45/99 (45%), Gaps = 2/99 (2%)
Query: 191 GHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPT 250
GH E A+ L + A + TPL AA G ++L E A+PN G T
Sbjct: 448 GHTEV--AKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHT 505
Query: 251 PLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVAS 289
PL+ AA GH+ V LL+ A + G TP VA+
Sbjct: 506 PLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAA 544
Score = 43.9 bits (102), Expect = 4e-04
Identities = 35/110 (31%), Positives = 55/110 (50%), Gaps = 9/110 (8%)
Query: 215 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADP 274
G TPL A ++L + GAS ++ G TPL+ A+F GHL V+ LL+ GA P
Sbjct: 371 GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASP 430
Query: 275 RVYAEDGSTPERVASLDTVVSVLRSWDLSLTEAMLQNMEAEQQRRAQEAQ 324
V TP +A+ R+ + + +LQN +A+ +A++ Q
Sbjct: 431 NVSNVKVETPLHMAA--------RAGHTEVAKYLLQN-KAKVNAKAKDDQ 471
Score = 43.5 bits (101), Expect = 5e-04
Identities = 35/125 (28%), Positives = 59/125 (47%), Gaps = 5/125 (4%)
Query: 192 HDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTP 251
++ A+ L R A G TPL A+ G + ++L + GA +K TP
Sbjct: 216 YENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTP 275
Query: 252 LYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVAS----LDTVVSVLRSWDLSLTEA 307
L+ AA GH+ E+LL GA + ++G +P +A+ LD V +L +D + +
Sbjct: 276 LHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLD-CVRLLLQYDAEIDDI 334
Query: 308 MLQNM 312
L ++
Sbjct: 335 TLDHL 339
Score = 42.0 bits (97), Expect = 0.002
Identities = 32/92 (34%), Positives = 39/92 (42%)
Query: 198 ARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAF 257
AR L + A E G TPL AA G + L A+ N G TPL+ A
Sbjct: 618 ARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQ 677
Query: 258 GGHLAAVEVLLKLGADPRVYAEDGSTPERVAS 289
GH+ +VL+K G G TP VAS
Sbjct: 678 EGHVPVADVLIKHGVMVDATTRMGYTPLHVAS 709
Score = 41.6 bits (96), Expect = 0.002
Identities = 31/103 (30%), Positives = 50/103 (48%), Gaps = 4/103 (3%)
Query: 199 RRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFG 258
+ L +R A + TPL AA G + + A N+K TPL+ AA
Sbjct: 421 KNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARI 480
Query: 259 GHLAAVEVLLKLGADPRVYAEDGSTPERVAS----LDTVVSVL 297
GH V++LL+ A+P + G TP +A+ ++TV+++L
Sbjct: 481 GHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALL 523
Score = 39.7 bits (91), Expect = 0.008
Identities = 26/75 (34%), Positives = 35/75 (46%)
Query: 215 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADP 274
G TPL A+ G ++ + GASPN TPL+ AA GH + LL+ A
Sbjct: 404 GLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKV 463
Query: 275 RVYAEDGSTPERVAS 289
A+D TP A+
Sbjct: 464 NAKAKDDQTPLHCAA 478
Score = 39.3 bits (90), Expect = 0.010
Identities = 27/82 (32%), Positives = 39/82 (47%)
Query: 215 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADP 274
G TPL AA Q + + G S N++ G TPL+ AA GH V +LL A+
Sbjct: 602 GYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANG 661
Query: 275 RVYAEDGSTPERVASLDTVVSV 296
+ + G TP + + + V V
Sbjct: 662 NLGNKSGLTPLHLVAQEGHVPV 683
Score = 38.1 bits (87), Expect = 0.022
Identities = 27/74 (36%), Positives = 35/74 (47%)
Query: 215 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADP 274
G+TPL AA G + E AS G TPL+ AA G + E+LL+ A P
Sbjct: 503 GHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHP 562
Query: 275 RVYAEDGSTPERVA 288
++G TP VA
Sbjct: 563 NAAGKNGLTPLHVA 576
Score = 37.4 bits (85), Expect = 0.038
Identities = 30/91 (32%), Positives = 42/91 (46%)
Query: 199 RRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFG 258
R L R A E + TPL AA G ++ + GA +K G +P++ AA G
Sbjct: 256 RLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQG 315
Query: 259 GHLAAVEVLLKLGADPRVYAEDGSTPERVAS 289
HL V +LL+ A+ D TP VA+
Sbjct: 316 DHLDCVRLLLQYDAEIDDITLDHLTPLHVAA 346
Score = 36.6 bits (83), Expect = 0.065
Identities = 27/83 (32%), Positives = 38/83 (45%)
Query: 215 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADP 274
G +P+ AA G ++L + A + TPL+ AA GH +VLL GA P
Sbjct: 305 GLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKP 364
Query: 275 RVYAEDGSTPERVASLDTVVSVL 297
A +G TP +A V V+
Sbjct: 365 NSRALNGFTPLHIACKKNHVRVM 387
Score = 36.2 bits (82), Expect = 0.085
Identities = 38/134 (28%), Positives = 55/134 (41%), Gaps = 9/134 (6%)
Query: 165 AAFDGDVGEIRAVL-KEVEQL-LTREG-------VGHDEAGEARRLQRRVALAECEDSYG 215
AA +G V + A+L KE Q +T++G + + A L R A G
Sbjct: 510 AAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNG 569
Query: 216 NTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADPR 275
TPL A ++L G SP+S G TPL+ AA + LL+ G
Sbjct: 570 LTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSAN 629
Query: 276 VYAEDGSTPERVAS 289
+ G TP +A+
Sbjct: 630 AESVQGVTPLHLAA 643
Score = 35.0 bits (79), Expect = 0.19
Identities = 20/53 (37%), Positives = 29/53 (54%)
Query: 215 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVL 267
G +PL +AA G + L + GASPN + G TPL A G+++ +VL
Sbjct: 734 GYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786
Score = 34.3 bits (77), Expect = 0.32
Identities = 27/75 (36%), Positives = 34/75 (45%)
Query: 215 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADP 274
G TPL AA QL GAS N G TPL+ A+ G++ V +LL GA
Sbjct: 206 GFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQI 265
Query: 275 RVYAEDGSTPERVAS 289
+D TP A+
Sbjct: 266 ETKTKDELTPLHCAA 280
Score = 29.6 bits (65), Expect = 8.0
Identities = 27/86 (31%), Positives = 33/86 (38%), Gaps = 2/86 (2%)
Query: 191 GHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPT 250
G DE R L A + G TPL AA ++ E GA+ N G T
Sbjct: 89 GQDEV--VRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFT 146
Query: 251 PLYRAAFGGHLAAVEVLLKLGADPRV 276
PL A GH V L+ G +V
Sbjct: 147 PLAVALQQGHENVVAHLINYGTKGKV 172
>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
Length = 1880
Score = 56.2 bits (134), Expect = 8e-08
Identities = 35/88 (39%), Positives = 45/88 (51%)
Query: 201 LQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGH 260
L + + E GNT L AA GQ ++ GA+ N++ G TPLY AA H
Sbjct: 64 LLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENH 123
Query: 261 LAAVEVLLKLGADPRVYAEDGSTPERVA 288
L V+ LL+ GA+ V EDG TP VA
Sbjct: 124 LEVVKFLLENGANQNVATEDGFTPLAVA 151
Score = 53.5 bits (127), Expect = 5e-07
Identities = 40/109 (36%), Positives = 51/109 (46%), Gaps = 2/109 (1%)
Query: 191 GHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPT 250
GH E A L + A C G TPL AA G+ +L E A PN+ G G T
Sbjct: 514 GHVETVLA--LLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLT 571
Query: 251 PLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVASLDTVVSVLRS 299
PL+ A +L V++LL G P A +G TP +A+ V V RS
Sbjct: 572 PLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARS 620
Score = 50.1 bits (118), Expect = 6e-06
Identities = 30/73 (41%), Positives = 38/73 (52%)
Query: 217 TPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADPRV 276
TPL AA G ++ + GA PNS+ G TPL+ A H+ +E+LLK GA
Sbjct: 340 TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDA 399
Query: 277 YAEDGSTPERVAS 289
E G TP VAS
Sbjct: 400 VTESGLTPLHVAS 412
Score = 49.3 bits (116), Expect = 1e-05
Identities = 30/82 (36%), Positives = 43/82 (52%)
Query: 215 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADP 274
G TPL A+ G ++ + A N+K G +PL++AA GH V +LLK GA P
Sbjct: 701 GYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASP 760
Query: 275 RVYAEDGSTPERVASLDTVVSV 296
+ DG+TP +A +SV
Sbjct: 761 NEVSSDGTTPLAIAKRLGYISV 782
Score = 44.7 bits (104), Expect = 2e-04
Identities = 34/99 (34%), Positives = 45/99 (45%), Gaps = 2/99 (2%)
Query: 191 GHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPT 250
GH E A+ L + A + TPL AA G ++L E A+PN G T
Sbjct: 448 GHTEV--AKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHT 505
Query: 251 PLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVAS 289
PL+ AA GH+ V LL+ A + G TP VA+
Sbjct: 506 PLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAA 544
Score = 43.9 bits (102), Expect = 4e-04
Identities = 35/110 (31%), Positives = 55/110 (50%), Gaps = 9/110 (8%)
Query: 215 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADP 274
G TPL A ++L + GAS ++ G TPL+ A+F GHL V+ LL+ GA P
Sbjct: 371 GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASP 430
Query: 275 RVYAEDGSTPERVASLDTVVSVLRSWDLSLTEAMLQNMEAEQQRRAQEAQ 324
V TP +A+ R+ + + +LQN +A+ +A++ Q
Sbjct: 431 NVSNVKVETPLHMAA--------RAGHTEVAKYLLQN-KAKVNAKAKDDQ 471
Score = 43.5 bits (101), Expect = 5e-04
Identities = 35/125 (28%), Positives = 59/125 (47%), Gaps = 5/125 (4%)
Query: 192 HDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTP 251
++ A+ L R A G TPL A+ G + ++L + GA +K TP
Sbjct: 216 YENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTP 275
Query: 252 LYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVAS----LDTVVSVLRSWDLSLTEA 307
L+ AA GH+ E+LL GA + ++G +P +A+ LD V +L +D + +
Sbjct: 276 LHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLD-CVRLLLQYDAEIDDI 334
Query: 308 MLQNM 312
L ++
Sbjct: 335 TLDHL 339
Score = 42.0 bits (97), Expect = 0.002
Identities = 32/92 (34%), Positives = 39/92 (42%)
Query: 198 ARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAF 257
AR L + A E G TPL AA G + L A+ N G TPL+ A
Sbjct: 618 ARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQ 677
Query: 258 GGHLAAVEVLLKLGADPRVYAEDGSTPERVAS 289
GH+ +VL+K G G TP VAS
Sbjct: 678 EGHVPVADVLIKHGVMVDATTRMGYTPLHVAS 709
Score = 41.6 bits (96), Expect = 0.002
Identities = 31/103 (30%), Positives = 50/103 (48%), Gaps = 4/103 (3%)
Query: 199 RRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFG 258
+ L +R A + TPL AA G + + A N+K TPL+ AA
Sbjct: 421 KNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARI 480
Query: 259 GHLAAVEVLLKLGADPRVYAEDGSTPERVAS----LDTVVSVL 297
GH V++LL+ A+P + G TP +A+ ++TV+++L
Sbjct: 481 GHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALL 523
Score = 39.7 bits (91), Expect = 0.008
Identities = 26/75 (34%), Positives = 35/75 (46%)
Query: 215 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADP 274
G TPL A+ G ++ + GASPN TPL+ AA GH + LL+ A
Sbjct: 404 GLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKV 463
Query: 275 RVYAEDGSTPERVAS 289
A+D TP A+
Sbjct: 464 NAKAKDDQTPLHCAA 478
Score = 39.3 bits (90), Expect = 0.010
Identities = 27/82 (32%), Positives = 39/82 (47%)
Query: 215 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADP 274
G TPL AA Q + + G S N++ G TPL+ AA GH V +LL A+
Sbjct: 602 GYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANG 661
Query: 275 RVYAEDGSTPERVASLDTVVSV 296
+ + G TP + + + V V
Sbjct: 662 NLGNKSGLTPLHLVAQEGHVPV 683
Score = 38.1 bits (87), Expect = 0.022
Identities = 27/74 (36%), Positives = 35/74 (47%)
Query: 215 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADP 274
G+TPL AA G + E AS G TPL+ AA G + E+LL+ A P
Sbjct: 503 GHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHP 562
Query: 275 RVYAEDGSTPERVA 288
++G TP VA
Sbjct: 563 NAAGKNGLTPLHVA 576
Score = 37.4 bits (85), Expect = 0.038
Identities = 30/91 (32%), Positives = 42/91 (46%)
Query: 199 RRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFG 258
R L R A E + TPL AA G ++ + GA +K G +P++ AA G
Sbjct: 256 RLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQG 315
Query: 259 GHLAAVEVLLKLGADPRVYAEDGSTPERVAS 289
HL V +LL+ A+ D TP VA+
Sbjct: 316 DHLDCVRLLLQYDAEIDDITLDHLTPLHVAA 346
Score = 36.6 bits (83), Expect = 0.065
Identities = 27/83 (32%), Positives = 38/83 (45%)
Query: 215 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADP 274
G +P+ AA G ++L + A + TPL+ AA GH +VLL GA P
Sbjct: 305 GLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKP 364
Query: 275 RVYAEDGSTPERVASLDTVVSVL 297
A +G TP +A V V+
Sbjct: 365 NSRALNGFTPLHIACKKNHVRVM 387
Score = 36.2 bits (82), Expect = 0.085
Identities = 38/134 (28%), Positives = 55/134 (41%), Gaps = 9/134 (6%)
Query: 165 AAFDGDVGEIRAVL-KEVEQL-LTREG-------VGHDEAGEARRLQRRVALAECEDSYG 215
AA +G V + A+L KE Q +T++G + + A L R A G
Sbjct: 510 AAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNG 569
Query: 216 NTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADPR 275
TPL A ++L G SP+S G TPL+ AA + LL+ G
Sbjct: 570 LTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSAN 629
Query: 276 VYAEDGSTPERVAS 289
+ G TP +A+
Sbjct: 630 AESVQGVTPLHLAA 643
Score = 35.0 bits (79), Expect = 0.19
Identities = 20/53 (37%), Positives = 29/53 (54%)
Query: 215 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVL 267
G +PL +AA G + L + GASPN + G TPL A G+++ +VL
Sbjct: 734 GYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786
Score = 34.3 bits (77), Expect = 0.32
Identities = 27/75 (36%), Positives = 34/75 (45%)
Query: 215 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADP 274
G TPL AA QL GAS N G TPL+ A+ G++ V +LL GA
Sbjct: 206 GFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQI 265
Query: 275 RVYAEDGSTPERVAS 289
+D TP A+
Sbjct: 266 ETKTKDELTPLHCAA 280
Score = 29.6 bits (65), Expect = 8.0
Identities = 27/86 (31%), Positives = 33/86 (38%), Gaps = 2/86 (2%)
Query: 191 GHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPT 250
G DE R L A + G TPL AA ++ E GA+ N G T
Sbjct: 89 GQDEV--VRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFT 146
Query: 251 PLYRAAFGGHLAAVEVLLKLGADPRV 276
PL A GH V L+ G +V
Sbjct: 147 PLAVALQQGHENVVAHLINYGTKGKV 172
>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
Length = 1719
Score = 56.2 bits (134), Expect = 8e-08
Identities = 35/88 (39%), Positives = 45/88 (51%)
Query: 201 LQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGH 260
L + + E GNT L AA GQ ++ GA+ N++ G TPLY AA H
Sbjct: 64 LLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENH 123
Query: 261 LAAVEVLLKLGADPRVYAEDGSTPERVA 288
L V+ LL+ GA+ V EDG TP VA
Sbjct: 124 LEVVKFLLENGANQNVATEDGFTPLAVA 151
Score = 53.5 bits (127), Expect = 5e-07
Identities = 40/109 (36%), Positives = 51/109 (46%), Gaps = 2/109 (1%)
Query: 191 GHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPT 250
GH E A L + A C G TPL AA G+ +L E A PN+ G G T
Sbjct: 514 GHVETVLA--LLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLT 571
Query: 251 PLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVASLDTVVSVLRS 299
PL+ A +L V++LL G P A +G TP +A+ V V RS
Sbjct: 572 PLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARS 620
Score = 50.1 bits (118), Expect = 6e-06
Identities = 30/73 (41%), Positives = 38/73 (52%)
Query: 217 TPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADPRV 276
TPL AA G ++ + GA PNS+ G TPL+ A H+ +E+LLK GA
Sbjct: 340 TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDA 399
Query: 277 YAEDGSTPERVAS 289
E G TP VAS
Sbjct: 400 VTESGLTPLHVAS 412
Score = 49.3 bits (116), Expect = 1e-05
Identities = 30/82 (36%), Positives = 43/82 (52%)
Query: 215 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADP 274
G TPL A+ G ++ + A N+K G +PL++AA GH V +LLK GA P
Sbjct: 701 GYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASP 760
Query: 275 RVYAEDGSTPERVASLDTVVSV 296
+ DG+TP +A +SV
Sbjct: 761 NEVSSDGTTPLAIAKRLGYISV 782
Score = 44.7 bits (104), Expect = 2e-04
Identities = 34/99 (34%), Positives = 45/99 (45%), Gaps = 2/99 (2%)
Query: 191 GHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPT 250
GH E A+ L + A + TPL AA G ++L E A+PN G T
Sbjct: 448 GHTEV--AKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHT 505
Query: 251 PLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVAS 289
PL+ AA GH+ V LL+ A + G TP VA+
Sbjct: 506 PLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAA 544
Score = 43.9 bits (102), Expect = 4e-04
Identities = 35/110 (31%), Positives = 55/110 (50%), Gaps = 9/110 (8%)
Query: 215 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADP 274
G TPL A ++L + GAS ++ G TPL+ A+F GHL V+ LL+ GA P
Sbjct: 371 GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASP 430
Query: 275 RVYAEDGSTPERVASLDTVVSVLRSWDLSLTEAMLQNMEAEQQRRAQEAQ 324
V TP +A+ R+ + + +LQN +A+ +A++ Q
Sbjct: 431 NVSNVKVETPLHMAA--------RAGHTEVAKYLLQN-KAKVNAKAKDDQ 471
Score = 43.5 bits (101), Expect = 5e-04
Identities = 35/125 (28%), Positives = 59/125 (47%), Gaps = 5/125 (4%)
Query: 192 HDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTP 251
++ A+ L R A G TPL A+ G + ++L + GA +K TP
Sbjct: 216 YENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTP 275
Query: 252 LYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVAS----LDTVVSVLRSWDLSLTEA 307
L+ AA GH+ E+LL GA + ++G +P +A+ LD V +L +D + +
Sbjct: 276 LHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLD-CVRLLLQYDAEIDDI 334
Query: 308 MLQNM 312
L ++
Sbjct: 335 TLDHL 339
Score = 42.0 bits (97), Expect = 0.002
Identities = 32/92 (34%), Positives = 39/92 (42%)
Query: 198 ARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAF 257
AR L + A E G TPL AA G + L A+ N G TPL+ A
Sbjct: 618 ARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQ 677
Query: 258 GGHLAAVEVLLKLGADPRVYAEDGSTPERVAS 289
GH+ +VL+K G G TP VAS
Sbjct: 678 EGHVPVADVLIKHGVMVDATTRMGYTPLHVAS 709
Score = 41.6 bits (96), Expect = 0.002
Identities = 31/103 (30%), Positives = 50/103 (48%), Gaps = 4/103 (3%)
Query: 199 RRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFG 258
+ L +R A + TPL AA G + + A N+K TPL+ AA
Sbjct: 421 KNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARI 480
Query: 259 GHLAAVEVLLKLGADPRVYAEDGSTPERVAS----LDTVVSVL 297
GH V++LL+ A+P + G TP +A+ ++TV+++L
Sbjct: 481 GHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALL 523
Score = 39.7 bits (91), Expect = 0.008
Identities = 26/75 (34%), Positives = 35/75 (46%)
Query: 215 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADP 274
G TPL A+ G ++ + GASPN TPL+ AA GH + LL+ A
Sbjct: 404 GLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKV 463
Query: 275 RVYAEDGSTPERVAS 289
A+D TP A+
Sbjct: 464 NAKAKDDQTPLHCAA 478
Score = 39.3 bits (90), Expect = 0.010
Identities = 27/82 (32%), Positives = 39/82 (47%)
Query: 215 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADP 274
G TPL AA Q + + G S N++ G TPL+ AA GH V +LL A+
Sbjct: 602 GYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANG 661
Query: 275 RVYAEDGSTPERVASLDTVVSV 296
+ + G TP + + + V V
Sbjct: 662 NLGNKSGLTPLHLVAQEGHVPV 683
Score = 38.1 bits (87), Expect = 0.022
Identities = 27/74 (36%), Positives = 35/74 (47%)
Query: 215 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADP 274
G+TPL AA G + E AS G TPL+ AA G + E+LL+ A P
Sbjct: 503 GHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHP 562
Query: 275 RVYAEDGSTPERVA 288
++G TP VA
Sbjct: 563 NAAGKNGLTPLHVA 576
Score = 37.4 bits (85), Expect = 0.038
Identities = 30/91 (32%), Positives = 42/91 (46%)
Query: 199 RRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFG 258
R L R A E + TPL AA G ++ + GA +K G +P++ AA G
Sbjct: 256 RLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQG 315
Query: 259 GHLAAVEVLLKLGADPRVYAEDGSTPERVAS 289
HL V +LL+ A+ D TP VA+
Sbjct: 316 DHLDCVRLLLQYDAEIDDITLDHLTPLHVAA 346
Score = 36.6 bits (83), Expect = 0.065
Identities = 27/83 (32%), Positives = 38/83 (45%)
Query: 215 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADP 274
G +P+ AA G ++L + A + TPL+ AA GH +VLL GA P
Sbjct: 305 GLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKP 364
Query: 275 RVYAEDGSTPERVASLDTVVSVL 297
A +G TP +A V V+
Sbjct: 365 NSRALNGFTPLHIACKKNHVRVM 387
Score = 36.2 bits (82), Expect = 0.085
Identities = 38/134 (28%), Positives = 55/134 (41%), Gaps = 9/134 (6%)
Query: 165 AAFDGDVGEIRAVL-KEVEQL-LTREG-------VGHDEAGEARRLQRRVALAECEDSYG 215
AA +G V + A+L KE Q +T++G + + A L R A G
Sbjct: 510 AAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNG 569
Query: 216 NTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADPR 275
TPL A ++L G SP+S G TPL+ AA + LL+ G
Sbjct: 570 LTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSAN 629
Query: 276 VYAEDGSTPERVAS 289
+ G TP +A+
Sbjct: 630 AESVQGVTPLHLAA 643
Score = 35.0 bits (79), Expect = 0.19
Identities = 20/53 (37%), Positives = 29/53 (54%)
Query: 215 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVL 267
G +PL +AA G + L + GASPN + G TPL A G+++ +VL
Sbjct: 734 GYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786
Score = 34.3 bits (77), Expect = 0.32
Identities = 27/75 (36%), Positives = 34/75 (45%)
Query: 215 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADP 274
G TPL AA QL GAS N G TPL+ A+ G++ V +LL GA
Sbjct: 206 GFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQI 265
Query: 275 RVYAEDGSTPERVAS 289
+D TP A+
Sbjct: 266 ETKTKDELTPLHCAA 280
Score = 29.6 bits (65), Expect = 8.0
Identities = 27/86 (31%), Positives = 33/86 (38%), Gaps = 2/86 (2%)
Query: 191 GHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPT 250
G DE R L A + G TPL AA ++ E GA+ N G T
Sbjct: 89 GQDEV--VRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFT 146
Query: 251 PLYRAAFGGHLAAVEVLLKLGADPRV 276
PL A GH V L+ G +V
Sbjct: 147 PLAVALQQGHENVVAHLINYGTKGKV 172
>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
Length = 1856
Score = 56.2 bits (134), Expect = 8e-08
Identities = 35/88 (39%), Positives = 45/88 (51%)
Query: 201 LQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGH 260
L + + E GNT L AA GQ ++ GA+ N++ G TPLY AA H
Sbjct: 64 LLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENH 123
Query: 261 LAAVEVLLKLGADPRVYAEDGSTPERVA 288
L V+ LL+ GA+ V EDG TP VA
Sbjct: 124 LEVVKFLLENGANQNVATEDGFTPLAVA 151
Score = 53.5 bits (127), Expect = 5e-07
Identities = 40/109 (36%), Positives = 51/109 (46%), Gaps = 2/109 (1%)
Query: 191 GHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPT 250
GH E A L + A C G TPL AA G+ +L E A PN+ G G T
Sbjct: 514 GHVETVLA--LLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLT 571
Query: 251 PLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVASLDTVVSVLRS 299
PL+ A +L V++LL G P A +G TP +A+ V V RS
Sbjct: 572 PLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARS 620
Score = 50.1 bits (118), Expect = 6e-06
Identities = 30/73 (41%), Positives = 38/73 (52%)
Query: 217 TPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADPRV 276
TPL AA G ++ + GA PNS+ G TPL+ A H+ +E+LLK GA
Sbjct: 340 TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDA 399
Query: 277 YAEDGSTPERVAS 289
E G TP VAS
Sbjct: 400 VTESGLTPLHVAS 412
Score = 49.3 bits (116), Expect = 1e-05
Identities = 30/82 (36%), Positives = 43/82 (52%)
Query: 215 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADP 274
G TPL A+ G ++ + A N+K G +PL++AA GH V +LLK GA P
Sbjct: 701 GYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASP 760
Query: 275 RVYAEDGSTPERVASLDTVVSV 296
+ DG+TP +A +SV
Sbjct: 761 NEVSSDGTTPLAIAKRLGYISV 782
Score = 44.7 bits (104), Expect = 2e-04
Identities = 34/99 (34%), Positives = 45/99 (45%), Gaps = 2/99 (2%)
Query: 191 GHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPT 250
GH E A+ L + A + TPL AA G ++L E A+PN G T
Sbjct: 448 GHTEV--AKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHT 505
Query: 251 PLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVAS 289
PL+ AA GH+ V LL+ A + G TP VA+
Sbjct: 506 PLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAA 544
Score = 43.9 bits (102), Expect = 4e-04
Identities = 35/110 (31%), Positives = 55/110 (50%), Gaps = 9/110 (8%)
Query: 215 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADP 274
G TPL A ++L + GAS ++ G TPL+ A+F GHL V+ LL+ GA P
Sbjct: 371 GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASP 430
Query: 275 RVYAEDGSTPERVASLDTVVSVLRSWDLSLTEAMLQNMEAEQQRRAQEAQ 324
V TP +A+ R+ + + +LQN +A+ +A++ Q
Sbjct: 431 NVSNVKVETPLHMAA--------RAGHTEVAKYLLQN-KAKVNAKAKDDQ 471
Score = 43.5 bits (101), Expect = 5e-04
Identities = 35/125 (28%), Positives = 59/125 (47%), Gaps = 5/125 (4%)
Query: 192 HDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTP 251
++ A+ L R A G TPL A+ G + ++L + GA +K TP
Sbjct: 216 YENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTP 275
Query: 252 LYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVAS----LDTVVSVLRSWDLSLTEA 307
L+ AA GH+ E+LL GA + ++G +P +A+ LD V +L +D + +
Sbjct: 276 LHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLD-CVRLLLQYDAEIDDI 334
Query: 308 MLQNM 312
L ++
Sbjct: 335 TLDHL 339
Score = 42.0 bits (97), Expect = 0.002
Identities = 32/92 (34%), Positives = 39/92 (42%)
Query: 198 ARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAF 257
AR L + A E G TPL AA G + L A+ N G TPL+ A
Sbjct: 618 ARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQ 677
Query: 258 GGHLAAVEVLLKLGADPRVYAEDGSTPERVAS 289
GH+ +VL+K G G TP VAS
Sbjct: 678 EGHVPVADVLIKHGVMVDATTRMGYTPLHVAS 709
Score = 41.6 bits (96), Expect = 0.002
Identities = 31/103 (30%), Positives = 50/103 (48%), Gaps = 4/103 (3%)
Query: 199 RRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFG 258
+ L +R A + TPL AA G + + A N+K TPL+ AA
Sbjct: 421 KNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARI 480
Query: 259 GHLAAVEVLLKLGADPRVYAEDGSTPERVAS----LDTVVSVL 297
GH V++LL+ A+P + G TP +A+ ++TV+++L
Sbjct: 481 GHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALL 523
Score = 39.7 bits (91), Expect = 0.008
Identities = 26/75 (34%), Positives = 35/75 (46%)
Query: 215 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADP 274
G TPL A+ G ++ + GASPN TPL+ AA GH + LL+ A
Sbjct: 404 GLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKV 463
Query: 275 RVYAEDGSTPERVAS 289
A+D TP A+
Sbjct: 464 NAKAKDDQTPLHCAA 478
Score = 39.3 bits (90), Expect = 0.010
Identities = 27/82 (32%), Positives = 39/82 (47%)
Query: 215 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADP 274
G TPL AA Q + + G S N++ G TPL+ AA GH V +LL A+
Sbjct: 602 GYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANG 661
Query: 275 RVYAEDGSTPERVASLDTVVSV 296
+ + G TP + + + V V
Sbjct: 662 NLGNKSGLTPLHLVAQEGHVPV 683
Score = 38.1 bits (87), Expect = 0.022
Identities = 27/74 (36%), Positives = 35/74 (47%)
Query: 215 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADP 274
G+TPL AA G + E AS G TPL+ AA G + E+LL+ A P
Sbjct: 503 GHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHP 562
Query: 275 RVYAEDGSTPERVA 288
++G TP VA
Sbjct: 563 NAAGKNGLTPLHVA 576
Score = 37.4 bits (85), Expect = 0.038
Identities = 30/91 (32%), Positives = 42/91 (46%)
Query: 199 RRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFG 258
R L R A E + TPL AA G ++ + GA +K G +P++ AA G
Sbjct: 256 RLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQG 315
Query: 259 GHLAAVEVLLKLGADPRVYAEDGSTPERVAS 289
HL V +LL+ A+ D TP VA+
Sbjct: 316 DHLDCVRLLLQYDAEIDDITLDHLTPLHVAA 346
Score = 36.6 bits (83), Expect = 0.065
Identities = 27/83 (32%), Positives = 38/83 (45%)
Query: 215 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADP 274
G +P+ AA G ++L + A + TPL+ AA GH +VLL GA P
Sbjct: 305 GLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKP 364
Query: 275 RVYAEDGSTPERVASLDTVVSVL 297
A +G TP +A V V+
Sbjct: 365 NSRALNGFTPLHIACKKNHVRVM 387
Score = 36.2 bits (82), Expect = 0.085
Identities = 38/134 (28%), Positives = 55/134 (41%), Gaps = 9/134 (6%)
Query: 165 AAFDGDVGEIRAVL-KEVEQL-LTREG-------VGHDEAGEARRLQRRVALAECEDSYG 215
AA +G V + A+L KE Q +T++G + + A L R A G
Sbjct: 510 AAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNG 569
Query: 216 NTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADPR 275
TPL A ++L G SP+S G TPL+ AA + LL+ G
Sbjct: 570 LTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSAN 629
Query: 276 VYAEDGSTPERVAS 289
+ G TP +A+
Sbjct: 630 AESVQGVTPLHLAA 643
Score = 35.0 bits (79), Expect = 0.19
Identities = 20/53 (37%), Positives = 29/53 (54%)
Query: 215 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVL 267
G +PL +AA G + L + GASPN + G TPL A G+++ +VL
Sbjct: 734 GYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786
Score = 34.3 bits (77), Expect = 0.32
Identities = 27/75 (36%), Positives = 34/75 (45%)
Query: 215 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADP 274
G TPL AA QL GAS N G TPL+ A+ G++ V +LL GA
Sbjct: 206 GFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQI 265
Query: 275 RVYAEDGSTPERVAS 289
+D TP A+
Sbjct: 266 ETKTKDELTPLHCAA 280
Score = 29.6 bits (65), Expect = 8.0
Identities = 27/86 (31%), Positives = 33/86 (38%), Gaps = 2/86 (2%)
Query: 191 GHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPT 250
G DE R L A + G TPL AA ++ E GA+ N G T
Sbjct: 89 GQDEV--VRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFT 146
Query: 251 PLYRAAFGGHLAAVEVLLKLGADPRV 276
PL A GH V L+ G +V
Sbjct: 147 PLAVALQQGHENVVAHLINYGTKGKV 172
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 55.5 bits (132), Expect = 1e-07
Identities = 90/394 (22%), Positives = 164/394 (41%), Gaps = 54/394 (13%)
Query: 70 EPRLGRAGGFESRPAEDRAARAIQGAFRQLRARRELARRREERREYLEQMETPQKEAYLA 129
E R R E ++ R Q R+ RRE +R+E E L+Q +++
Sbjct: 482 EERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQ---- 537
Query: 130 PVRREQEAAR---------RLREQEEAAQRERREELQRRRRLLDAAFDGDVGEIRAVLKE 180
+RREQE R + EQE QR +RE+ +RR +LL + ++ +E
Sbjct: 538 -LRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEE 596
Query: 181 -VEQLLTREGVGHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGA 239
+EQ L RE V E E R ++R+ E E+ L ++ + QLR E
Sbjct: 597 RLEQRLKREEVERLEQEERR--EQRLKREEPEEE-RRQQLLKSEEQEERRQQQLRREQQE 653
Query: 240 SPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVASLDTVVSVLRS 299
+ L R L E LK + ++ + E+ + + + S +
Sbjct: 654 RREQR-------LKREEEEERL---EQRLKREHEEERREQELAEEEQEQARERIKSRIPK 703
Query: 300 WDLSL-TEAMLQNMEAEQQRRAQEAQRHKEAEAERMTLKVQQLT-REQQQCHKELQQ--- 354
W L +EA + + + R QE QR ++ + E+ + +L +E+++ H++ Q+
Sbjct: 704 WQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQ 763
Query: 355 ----------------AYCELSRR--ISEHDQCEWRCMDKTKLTLQAIKDTEAQVDRLRQ 396
LS R + E + + R ++ + + + + E + R RQ
Sbjct: 764 RRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQ 823
Query: 397 EAQKAEEALAM---ARLELREQTQEGEEEAPGLK 427
++ +E + +L+ RE+ Q+ +EE GL+
Sbjct: 824 RREREKELQFLEEEEQLQRRERAQQLQEEEDGLQ 857
Score = 55.1 bits (131), Expect = 2e-07
Identities = 90/356 (25%), Positives = 142/356 (39%), Gaps = 66/356 (18%)
Query: 99 LRARRELARRREERREYLEQMETPQKEAYLA----PVRREQEAARRLREQEEAAQRER-- 152
LR E RR+E R+ E+ E Q+E L RR QE R+ RE+EE Q E
Sbjct: 1094 LREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQL 1153
Query: 153 -REELQRRRRLLDAAFDGDVGEIRAVLKEVEQLLTREGVGHDEAGEARRLQRRVALAECE 211
REE ++RRR E+ +E E+L E E E RR +R E E
Sbjct: 1154 LREEPEKRRRQ----------ELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEE 1203
Query: 212 DSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLG 271
+ Q ++ + E P + A
Sbjct: 1204 ELQRQKRKQRYRDEDQRSDLKWQWE----PEKENAV------------------------ 1235
Query: 272 ADPRVYAEDGSTPERVASLDTVVSVLRSWDLSLTEAMLQNMEAEQQRRAQEAQRHKEAEA 331
D +VY + G E+ L+ S LR ++ LQ++ EQQ R +E +R + +
Sbjct: 1236 RDNKVYCK-GRENEQFRQLED--SQLRDRQ---SQQDLQHLLGEQQERDREQERRRWQQR 1289
Query: 332 ERMTLKVQQLTREQQ----------QCHKELQQAYCELSRRISEHD----QCEWRCMDKT 377
+R + +QL RE+Q Q K+L + E RR E D + E ++
Sbjct: 1290 DRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQERE 1349
Query: 378 KLTL-QAIKDTEAQVDRLRQEAQKAEEALAMARLELREQTQEGEEEAPGLKCQVTE 432
+ L + +D + + + LR + Q + RL +E+ ++ +E L+CQ E
Sbjct: 1350 EQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQERE 1405
Score = 53.1 bits (126), Expect = 7e-07
Identities = 89/359 (24%), Positives = 144/359 (40%), Gaps = 64/359 (17%)
Query: 99 LRARRELARRREERREYLEQMETPQKEAYL----APVRREQEAARRLREQEEAAQRER-- 152
LR RE RR+E R+Y + + QKE L RR QE ++ RE+EE Q E
Sbjct: 944 LREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQL 1003
Query: 153 -REELQRRRRLLDAAFDGDVGEIRAVLKEVEQLLTREGVGHDEAGEARRLQRRVALAECE 211
REE ++RRR ++ + + +E EQLL E E RRLQ R E
Sbjct: 1004 LREEREKRRR---QEWERQYRKKDELQQEEEQLLREE-------REKRRLQERERQYREE 1053
Query: 212 DSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLG 271
+ E G+ + R EL + E LL+
Sbjct: 1054 EELQQ---EEEQLLGEERETRRRQELERQYRKEEELQQEE-------------EQLLR-- 1095
Query: 272 ADPRVYAEDGSTPERVASLDTVVSVLRSWDLSLTEAMLQNMEAEQQRRAQEAQRHKEAEA 331
PE+ + +L E L E E++RR QE +R + E
Sbjct: 1096 ----------EEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRR-QELER-QYREE 1143
Query: 332 ERMTLKVQQLTREQQQCHKELQQAYCELSRRISEHDQCEWRCMDKTKLTLQAIKDTEAQV 391
E + + +QL RE+ + K +Q EL R+ E ++ + + Q +++ + +
Sbjct: 1144 EEVQQEEEQLLREEPE--KRRRQ---ELERQYREEEELQ-------QEEEQLLREEQEKR 1191
Query: 392 DRLRQEAQKAEEALAMARLELREQTQEGEEEAPGLKCQVTELHDVLMKDVGNRIRADGR 450
+ R+ + EE L + + R+Q E++ LK Q + ++D N++ GR
Sbjct: 1192 RQERERQYREEEEL---QRQKRKQRYRDEDQRSDLKWQWEPEKENAVRD--NKVYCKGR 1245
Score = 48.9 bits (115), Expect = 1e-05
Identities = 43/125 (34%), Positives = 56/125 (44%), Gaps = 24/125 (19%)
Query: 85 EDRAARAIQGAFRQLRARRELA--------------RRREERREYLEQMETPQKEAYLA- 129
E+R R +Q RQ R EL RR+E R+Y ++ E Q+E L
Sbjct: 1036 EEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLR 1095
Query: 130 ---PVRREQEAARRLREQEEAAQRER---REELQRRRRLLDAAFDGDVGEIRAVLKEVEQ 183
RR QE R+ RE+EE Q E REE ++RRR + E V +E EQ
Sbjct: 1096 EEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRR---QELERQYREEEEVQQEEEQ 1152
Query: 184 LLTRE 188
LL E
Sbjct: 1153 LLREE 1157
Score = 48.5 bits (114), Expect = 2e-05
Identities = 77/353 (21%), Positives = 142/353 (40%), Gaps = 47/353 (13%)
Query: 85 EDRAARAIQGAFRQLRA--RRELARRREERREYLEQMETPQKEAYLAPVRREQEAARRLR 142
E + R +Q QLR R+EL R R+E + +++ Q+ +RR+QE RR +
Sbjct: 264 EPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQ------LRRKQEEERREQ 317
Query: 143 EQEEAAQRERREELQRRR--RLLDAAFDGDVGEIRAVLKEV--EQLLTREGVGHDEAGEA 198
++E Q+ERRE+ + RR +L + ++R +E EQ L RE +E
Sbjct: 318 QEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRRE---QEEERRE 374
Query: 199 RRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFG 258
++L+R L + L + ++ +L +
Sbjct: 375 QQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRR------------- 421
Query: 259 GHLAAVEVLLKLGADPRVYAEDGSTPERVASLDTVVSVLRSWDLSLTEAMLQNMEAEQQR 318
E L+ + + + R L R W E + E E+++
Sbjct: 422 ------EQQLRREQEEERHEQKHEQERREQRLKREQEERRDW--LKREEETERHEQERRK 473
Query: 319 RAQEAQRHKEAEAERMTLKV------QQLTREQQQCHKELQQAYCELSRRISEHDQCEWR 372
Q+ +R +E E LK+ +Q R +QQ +E ++ + +R E ++ + R
Sbjct: 474 --QQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQR 531
Query: 373 CMDKTKLTLQAIKDTEAQVDR---LRQEAQKAEEALAMARLELREQTQEGEEE 422
+ +L + + E + R R E ++ E+ L + E R+Q + EEE
Sbjct: 532 LRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEE 584
Score = 47.8 bits (112), Expect = 3e-05
Identities = 47/146 (32%), Positives = 64/146 (43%), Gaps = 19/146 (13%)
Query: 66 LCGREPRLGRAGGFESRPAEDRAARAIQGAFRQLRARRELARRREERREYLEQMETPQKE 125
L G EP R E + E+ + Q + LR RE RR+E R+Y ++ E Q+E
Sbjct: 973 LLGEEPEKRRRQEREKKYREEEELQ--QEEEQLLREEREKRRRQEWERQYRKKDELQQEE 1030
Query: 126 AYLAPVRRE----QEAARRLREQEEAAQRERR---EELQRRRRLLDAAFDGDVGEIRAVL 178
L RE QE R+ RE+EE Q E + EE + RRR E+
Sbjct: 1031 EQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRR----------QELERQY 1080
Query: 179 KEVEQLLTREGVGHDEAGEARRLQRR 204
++ E+L E E E RR Q R
Sbjct: 1081 RKEEELQQEEEQLLREEPEKRRRQER 1106
Score = 46.6 bits (109), Expect = 6e-05
Identities = 84/357 (23%), Positives = 144/357 (40%), Gaps = 47/357 (13%)
Query: 73 LGRAGGFESRPAEDRAARAIQGAFRQLRARRELARRREERREYLEQMETPQKEAYLAPVR 132
LG+A G + E RA + + Q R + E RR E R LE+ ++ +
Sbjct: 89 LGQATGLDE---EKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRR------Q 139
Query: 133 REQEAARRLREQEEAAQR-ERREELQRRRRLLDAAFDGDVGEIRAVLK-EVEQLLTREGV 190
+ QE R L E EE +++ ER E+ R+RR + + R + E EQL + +G
Sbjct: 140 KRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGH 199
Query: 191 GHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPT 250
+E + +L+RR L E G+ Q R E
Sbjct: 200 ETEEFPDEEQLRRR-------------ELLELRRKGREEKQQQRRE-----------RQD 235
Query: 251 PLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVASLDTVVSVLRSWDLSLTEAMLQ 310
+++ E +L+ + ++ E+ P+R L LR + Q
Sbjct: 236 RVFQEEEEKEWRKRETVLR-KEEEKLQEEE---PQRQRELQEEEEQLRKLERQELRRERQ 291
Query: 311 NMEAEQQRRAQEAQRHKEAEAERMTLKVQQLTREQQQCHKELQQAYCELSRRISEHDQCE 370
E +QQR +E Q ++ E ER + QQ R +QQ +E Q+ E R + ++ E
Sbjct: 292 EEEQQQQRLRREQQLRRKQEEER---REQQEERREQQERREQQEERREQQLRREQEERRE 348
Query: 371 WRCM-----DKTKLTLQAIKDTEAQVDRLRQEAQKAEEALAMARLELREQTQEGEEE 422
+ ++ + L+ ++ E + +LR+E Q E +LR + Q E+
Sbjct: 349 QQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQ 405
Score = 45.4 bits (106), Expect = 1e-04
Identities = 85/370 (22%), Positives = 139/370 (37%), Gaps = 30/370 (8%)
Query: 80 ESRPAEDRAARAIQGAFRQLRARRELARRREERREYLEQMETPQKEAYLAPVRREQEAAR 139
E + R R Q + LR RE RRR+E + E +E P+RR QE R
Sbjct: 1302 EEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRR-QERDR 1360
Query: 140 RLREQEEAAQRERR----EELQRRRRLLDAAFDGDVGEIRAVLKEVEQLLTREGVGHDEA 195
+ RE+E Q + R EE + RR+ + F + ++R +E + R+ +E
Sbjct: 1361 KFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEE 1420
Query: 196 GEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAF----GPTP 251
+ R +R E E + QLR E +
Sbjct: 1421 QQLSRQERDRKFREEEQQVRRQERERKFLEEEQ---QLRQERHRKFREEEQLLQEREEQQ 1477
Query: 252 LYRAAFGGHLAAVEVLLKLGADPRVYAED---GSTPER--VASLDTVVSVLRSWDLSLTE 306
L+R E L+ R + E PER + + R E
Sbjct: 1478 LHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEE 1537
Query: 307 AMLQNMEAEQQRRAQEAQRHKEAEAERMTLKVQQLTREQQQCHKELQQAYCELSRRISEH 366
L+ E QQRR ++ +E E R + QQL+R+++ L++ +++
Sbjct: 1538 QQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEE------QKVRRQ 1591
Query: 367 DQCEWRCMDKTKLTLQAIKDTEAQVDRLRQEAQKAEEALAMARLELREQTQEGE----EE 422
+Q D+ +L Q + + Q+ + R + +E L R E + QE + EE
Sbjct: 1592 EQERKFMEDEQQLRRQ---EGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEE 1648
Query: 423 APGLKCQVTE 432
P L+ Q E
Sbjct: 1649 EPQLRRQERE 1658
Score = 43.1 bits (100), Expect = 7e-04
Identities = 33/95 (34%), Positives = 50/95 (52%), Gaps = 7/95 (7%)
Query: 69 REPRLGRAGGFESRPAEDRAARAIQGAFRQLRARRELARRREERREYLEQMETPQKEAYL 128
++ RL R + E+R R Q R+ + RRE ++EERRE +Q+ Q+E
Sbjct: 296 QQQRLRREQQLRRKQEEER--REQQEERREQQERRE---QQEERRE--QQLRREQEERRE 348
Query: 129 APVRREQEAARRLREQEEAAQRERREELQRRRRLL 163
+RREQE RR ++ + ERRE+ RR + L
Sbjct: 349 QQLRREQEEERREQQLRREQEEERREQQLRREQQL 383
Score = 42.4 bits (98), Expect = 0.001
Identities = 88/381 (23%), Positives = 140/381 (36%), Gaps = 56/381 (14%)
Query: 81 SRPAEDRAARAIQGAFRQLRARRELARRREERREYLEQMETPQKEAYL------------ 128
SRP + R Q + R R + +EE R + +Q E Q+ +
Sbjct: 721 SRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERG 780
Query: 129 -------APVRREQEAARRLREQEEAAQR-----ERREELQRRRRLLDAAFDGDVGEIRA 176
P+R ++E R E+++ QR E +E+ +R+RR + E +
Sbjct: 781 RQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQL 840
Query: 177 VLKEVEQLLTREGVGHDEAGEARRLQR-------RVALAE-----CEDSYGNTPLSEAAA 224
+E Q L E G E E RR Q R L E Y L E
Sbjct: 841 QRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLR 900
Query: 225 GGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTP 284
Q L + EL K E LL+ + R E
Sbjct: 901 KEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQE----R 956
Query: 285 ERVASLDTVVSVLRSWDLSLTEAMLQNMEAEQQRRAQEAQRHKEAEAERMTLKVQQLTRE 344
ER D L E L E E++RR + ++++ E E + + +QL RE
Sbjct: 957 ERQYRKDK--------KLQQKEEQLLGEEPEKRRRQEREKKYR--EEEELQQEEEQLLRE 1006
Query: 345 QQQCHKELQQAYCELSRRISEHDQCEWRCM--DKTKLTLQAIKDTEAQVDRLRQEAQK-- 400
+++ K +Q + R+ E Q E + + ++ K LQ + + + L+QE ++
Sbjct: 1007 ERE--KRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLL 1064
Query: 401 AEEALAMARLELREQTQEGEE 421
EE R EL Q ++ EE
Sbjct: 1065 GEERETRRRQELERQYRKEEE 1085
Score = 42.0 bits (97), Expect = 0.002
Identities = 90/389 (23%), Positives = 155/389 (39%), Gaps = 50/389 (12%)
Query: 68 GREPRLGRAGGFESRPAEDRAARAIQGAFRQLRARRELARRREERREYLEQMETPQKEAY 127
GR+ R E R + RA Q R L E +RR +RRE ++++ ++E
Sbjct: 780 GRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQ 839
Query: 128 LAPVRREQEAARRLREQEEAAQ--RERR----------------EELQRRRRLLDA--AF 167
L + +E A++L+E+E+ Q +ERR EE +RRR L A A
Sbjct: 840 L----QRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPAL 895
Query: 168 DGDVGEIRAVLKEVEQLLTREGVGHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQ 227
+ + + +L+E E+ L RE E R R + E+ E Q
Sbjct: 896 QEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRR-RQ 954
Query: 228 PLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERV 287
Q R + + G P R E + ++ E+ E+
Sbjct: 955 ERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREE---REKR 1011
Query: 288 ASLDTVVSVLRSWDLSLTEAMLQNMEAEQQRRAQEAQRHKEAE-----------AERMTL 336
+ + +L E L E E++R + ++++E E ER T
Sbjct: 1012 RRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETR 1071
Query: 337 KVQQLTREQQQCHKELQQAYCELSRRISE---HDQCEWRCMDKTKLTLQAIKDTEAQVDR 393
+ Q+L R+ ++ +ELQQ +L R E + E +C ++ +L + E Q+ R
Sbjct: 1072 RRQELERQYRK-EEELQQEEEQLLREEPEKRRRQERERQCREEEEL-----QQEEEQLLR 1125
Query: 394 LRQEAQKAEEALAMARLELREQTQEGEEE 422
+E ++ +E R E E+ Q+ EE+
Sbjct: 1126 EEREKRRRQELERQYREE--EEVQQEEEQ 1152
Score = 42.0 bits (97), Expect = 0.002
Identities = 77/358 (21%), Positives = 142/358 (39%), Gaps = 36/358 (10%)
Query: 69 REPRLGRAGGFESRPAEDRAARAIQGAFRQLRARRELARRREERREYLEQMETPQKEAYL 128
RE +L + + R E + +R Q R+ R + RR+E R++LE+ + ++E +
Sbjct: 1404 REQQLRQDRDRKFREEEQQLSR--QERDRKFREEEQQVRRQERERKFLEEEQQLRQERHR 1461
Query: 129 APVRREQEAARRLREQEEAAQRER-----REELQRRRRLLDAAFDGDVGEIRAVLKEVEQ 183
RE+E + RE+++ ++ER EE Q RR+ D F E+R+ E +
Sbjct: 1462 K--FREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQ--ELRSQEPE-RK 1516
Query: 184 LLTREGVGHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNS 243
L E H + + + LQ L E + + Q R E
Sbjct: 1517 FLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREE------- 1569
Query: 244 KGAFGPTPLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVASLDTVVSVLRSWDLS 303
L R E ++ R + ED R + R
Sbjct: 1570 ------QQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQE-RDRKFR 1622
Query: 304 LTEAMLQNMEAEQQRRAQEAQRHKEAEAERMTLKVQQLTREQQQCHKELQQAYCELSRRI 363
E +LQ E +Q R + ++ E E + +++ REQQ H + + + E + +
Sbjct: 1623 EDEQLLQEREEQQLHRQERDRKFLEEEPQ-----LRRQEREQQLRH-DRDRKFREEEQLL 1676
Query: 364 SEHDQCEWRCMDKTKLTLQAIKDTEAQVDRLRQEAQKAEEALAMARLELREQTQEGEE 421
E ++ + R ++ + ++ E Q+ R +E + +E + R EL + +E E+
Sbjct: 1677 QEGEEQQLRRQERDR----KFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQ 1730
Score = 39.7 bits (91), Expect = 0.008
Identities = 30/95 (31%), Positives = 50/95 (52%), Gaps = 2/95 (2%)
Query: 69 REPRLGRAGGFESRPA-EDRAARAIQGAFRQLRARRELARRREERREYLEQMETPQKEAY 127
RE +L R E R E+R + + ++ R ++L R +EERRE + E ++E
Sbjct: 302 REQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQ-EEERR 360
Query: 128 LAPVRREQEAARRLREQEEAAQRERREELQRRRRL 162
+RREQE RR ++ Q R ++L+R ++L
Sbjct: 361 EQQLRREQEEERREQQLRREQQLRREQQLRREQQL 395
Score = 39.7 bits (91), Expect = 0.008
Identities = 32/96 (33%), Positives = 48/96 (50%), Gaps = 5/96 (5%)
Query: 69 REPRLGRAGGFESRPAE---DRAARAIQGAFRQLRARRELARRREERREYLEQMETPQKE 125
RE +L R E R + ++ R Q R+ + RRE RRE++ +Q+ Q+
Sbjct: 360 REQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQL 419
Query: 126 AYLAPVRREQEAAR--RLREQEEAAQRERREELQRR 159
+RREQE R + EQE QR +RE+ +RR
Sbjct: 420 RREQQLRREQEEERHEQKHEQERREQRLKREQEERR 455
Score = 38.9 bits (89), Expect = 0.013
Identities = 83/348 (23%), Positives = 129/348 (37%), Gaps = 32/348 (9%)
Query: 85 EDRAARAIQGAFRQLRARRELARRREERREYLEQMETPQKEAYLAPVRREQEAARRLREQ 144
++R + Q R+ R +L + REE++ L + E +K R QE R+ E
Sbjct: 1543 QERGQQRRQDRDRKFREEEQLRQEREEQQ--LSRQERDRKFRLEEQKVRRQEQERKFMED 1600
Query: 145 EEAAQRERREELQRRRRLLDAAFDGDVGEIRAVLKE-VEQLLTREGVGH---DEAGEARR 200
E+ +R+ ++ R+ R D E +L+E EQ L R+ +E + RR
Sbjct: 1601 EQQLRRQEGQQQLRQER------DRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRR 1654
Query: 201 LQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGH 260
+R L D G + QLR + + K L R
Sbjct: 1655 QEREQQLRHDRDRKFREEEQLLQEGEEQ---QLRRQ---ERDRKFREEEQQLRRQERERK 1708
Query: 261 LAAVEVLLKLGADPRVYAEDGSTPERVASLDTVVSVLRSWDLS---LTEAMLQNMEAEQQ 317
E L+ R + E+ + +T LR + L E L+ EQQ
Sbjct: 1709 FLQEEQQLRRQELERKFREEEQLRQ-----ETEQEQLRRQERYRKILEEEQLRPEREEQQ 1763
Query: 318 RRAQEAQRHKEAEAERMTLKVQQLTREQQQCHKELQQAYCELSRRISEHDQCEWRCMDKT 377
R QE R E + + +Q R Q+ K ++ E R+ E Q + D
Sbjct: 1764 LRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREE---EQLRQEREEQQLRPQQRDGK 1820
Query: 378 KLTLQAIKDTEAQVDRLRQEAQK---AEEALAMARLELREQTQEGEEE 422
+ E Q RLRQE + AEE A RE+ + +EE
Sbjct: 1821 YRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEE 1868
Score = 38.1 bits (87), Expect = 0.022
Identities = 79/363 (21%), Positives = 145/363 (39%), Gaps = 35/363 (9%)
Query: 69 REPRLGRAGGFESRPAEDRAARAIQGAFRQLRARRELARRREERREYLEQMETPQKEAYL 128
RE +L R E + ++ R Q R+ + RRE RRE+ E EQ ++E
Sbjct: 391 REQQLRR----EQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKH--EQERRE 444
Query: 129 APVRREQEAARRLREQEEAAQR----------ERREELQRRRRLLDAAFDGDVGEIRAVL 178
++REQE R ++EE +R +R +E +RR R L + E R
Sbjct: 445 QRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKL----EEEERREQQ 500
Query: 179 KEVEQLLTREGVGHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELG 238
+ EQ L RE + R ++R+ E E+ SE + + R E
Sbjct: 501 ERREQQLRRE--------QEERREQRLKRQEEEERLQQRLRSEQQLRREQ---EERREQL 549
Query: 239 ASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVASLDTVVSVLR 298
+ + + LLK + R ER+ V R
Sbjct: 550 LKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVER 609
Query: 299 SWDLSLTEAMLQNMEAEQQRRAQEAQRHKEAEAERMTLKVQQLTREQQQCHKELQQAYCE 358
E L+ E E++RR Q + ++ E + L+ +Q R +Q+ +E ++ E
Sbjct: 610 LEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLE 669
Query: 359 LS-RRISEHDQCEWRCMDKTKLTLQAIKDTEAQVDRLRQEAQKAEEALAMARLELREQTQ 417
+R E ++ E ++ + QA + ++++ + + + + +A +++ R + Q
Sbjct: 670 QRLKREHEEERREQELAEEEQ--EQARERIKSRIPKWQWQLESEADA-RQSKVYSRPRKQ 726
Query: 418 EGE 420
EG+
Sbjct: 727 EGQ 729
Score = 37.4 bits (85), Expect = 0.038
Identities = 33/113 (29%), Positives = 52/113 (46%), Gaps = 29/113 (25%)
Query: 80 ESRPAEDRAARAIQGAFRQLRARRELARRREERREYLEQMETPQKEAYLAPVRREQEAAR 139
E E++ R Q RQ RA + A + + RRE E + ++ +R QE R
Sbjct: 1826 EQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQ-------KRRQERER 1878
Query: 140 RLREQEEAAQRERREELQRRRRLLDAAFDGDVGEIRAVLKEVEQLLTREGVGH 192
+LR EE +R+++EE + R+ VGEI+ ++EG GH
Sbjct: 1879 KLR--EEHIRRQQKEEQRHRQ----------VGEIK----------SQEGKGH 1909
Score = 37.0 bits (84), Expect = 0.050
Identities = 27/132 (20%), Positives = 68/132 (51%), Gaps = 8/132 (6%)
Query: 310 QNMEAEQQRRAQEAQRHKEAEAERMTLKVQQLTREQQQCHKELQQAYCELSRRISEHDQC 369
Q ++ E+++R ++ +R + + E+ + Q L RE+++ + L++ E + + ++
Sbjct: 548 QLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEV 607
Query: 370 EWRCMDKTKLTLQAIKDTEAQVDRLRQ------EAQKAEEALAMARLELREQTQEGEEEA 423
E +++ + Q +K E + +R +Q + ++ ++ L + E REQ + EEE
Sbjct: 608 ER--LEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEE 665
Query: 424 PGLKCQVTELHD 435
L+ ++ H+
Sbjct: 666 ERLEQRLKREHE 677
Score = 36.2 bits (82), Expect = 0.085
Identities = 38/127 (29%), Positives = 52/127 (40%), Gaps = 35/127 (27%)
Query: 69 REPRLGRAGGFESR-----PAEDRAARAIQGAFRQLRARRELARRREERREYLEQM---- 119
RE RL R E R +E++ R Q R+ + RRE +REE E LEQ
Sbjct: 616 REQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKRE 675
Query: 120 -ETPQKEAYLAPVRREQEAAR-------------------------RLREQEEAAQRERR 153
E ++E LA +EQ R R R+QE +R+ +
Sbjct: 676 HEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQ 735
Query: 154 EELQRRR 160
EE +RRR
Sbjct: 736 EEKRRRR 742
Score = 36.2 bits (82), Expect = 0.085
Identities = 77/363 (21%), Positives = 129/363 (35%), Gaps = 80/363 (22%)
Query: 97 RQLRARRELARRREERREYLEQMETPQKEAYLAPVRREQEAARRLREQEEAAQR------ 150
R+ R + RR+E+ R+++E + +++ +R+E++ R+ RE E+ Q
Sbjct: 1579 RKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERD--RKFREDEQLLQEREEQQL 1636
Query: 151 ----------ERREELQRRRRLLDAAFDGDVGEIRAVLKEVEQLLT-----------REG 189
E +L+R+ R D D +E EQLL R+
Sbjct: 1637 HRQERDRKFLEEEPQLRRQEREQQLRHDRD-----RKFREEEQLLQEGEEQQLRRQERDR 1691
Query: 190 VGHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGP 249
+E + RR +R + E L + QLR E
Sbjct: 1692 KFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEE----QLRQE------------- 1734
Query: 250 TPLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVASLDTVVSVLRSWDLSLTEAML 309
E L + ++ E+ PER R + E L
Sbjct: 1735 ------------TEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFR---EEEQL 1779
Query: 310 QNMEAEQQRRAQEAQR-HKEAEAERMTLKVQQL-----------TREQQQCHKELQQAYC 357
+ EQQ R+QE+ R +E E R + QQL EQ Q ++ Q+
Sbjct: 1780 RQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQ 1839
Query: 358 ELSRRISEHDQCEWRCMDKTKLTLQAIKDTEAQVDRLRQEAQKAEEALAMARLELREQTQ 417
E R+ +Q + +K++ Q + E Q R +E + EE + + E + Q
Sbjct: 1840 ERDRQYRAEEQ--FATQEKSRREEQELWQEEEQKRRQERERKLREEHIRRQQKEEQRHRQ 1897
Query: 418 EGE 420
GE
Sbjct: 1898 VGE 1900
Score = 35.8 bits (81), Expect = 0.11
Identities = 80/350 (22%), Positives = 137/350 (39%), Gaps = 54/350 (15%)
Query: 97 RQLRARRELARRREERREYLEQMETPQKEAYLAPVRREQEAARRLREQEEAAQ--RERRE 154
+Q R R + RR ++R + + E ++E ++EA RR R+ +E Q RE RE
Sbjct: 1274 QQERDREQERRRWQQRDRHFPEEEQLERE-------EQKEAKRRDRKSQEEKQLLREERE 1326
Query: 155 ELQRRRRLLDAAFDGDVGEIRAVLKEVEQLLTR----------EGVGHDEAG-----EAR 199
E +RRR+ D F E +L+E E+ R E + H E G E +
Sbjct: 1327 E-KRRRQETDRKF----REEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQ 1381
Query: 200 RLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLR-AELGASPNSKGAFGPTPLYRAAFG 258
RL+R+ E E + L E Q L Q R +L + K L R
Sbjct: 1382 RLRRQ----ERERKF----LKEE----QQLRCQEREQQLRQDRDRKFREEEQQLSRQERD 1429
Query: 259 GHLAAVEVLLKLGADPRVYAED-----GSTPERVASLDTVVSVLRSWDLSLTEAMLQNME 313
E ++ R + E+ + + ++ L E + +E
Sbjct: 1430 RKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLE 1489
Query: 314 AEQQRRAQEAQRHKEAEAERMTLKVQQLTREQQQCHK-ELQQAYCELSRRISEHDQCEWR 372
EQQ R QE R + R ++ E+QQ H+ + Q+ + + +++ ++ + R
Sbjct: 1490 EEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQR 1549
Query: 373 CMDKTKLTLQAIKDTEAQVDRLRQEAQKAEEALAMARLELREQTQEGEEE 422
D+ + K E + R +E Q+ + L EQ +E+
Sbjct: 1550 RQDRDR------KFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQ 1593
Score = 33.5 bits (75), Expect = 0.55
Identities = 29/91 (31%), Positives = 45/91 (49%), Gaps = 10/91 (10%)
Query: 69 REPRLGRAGGFESRPAEDRAARAIQGAFRQLRARRELARRREERREYLEQMETPQKEAYL 128
RE +L R E + ++ R Q R+ + RRE RRE++ +Q+ Q+E
Sbjct: 379 REQQLRR----EQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEE-- 432
Query: 129 APVRREQEAARRLREQE-EAAQRERREELQR 158
R EQ+ + REQ + Q ERR+ L+R
Sbjct: 433 ---RHEQKHEQERREQRLKREQEERRDWLKR 460
Score = 33.1 bits (74), Expect = 0.72
Identities = 34/136 (25%), Positives = 58/136 (42%), Gaps = 4/136 (2%)
Query: 69 REPRLGRAGGFESRPAEDRAARAIQGAFRQLRARRELARRREERREYLEQMETPQKEAYL 128
RE R E+R + ++ + R ++L R ++ RRE +Q+ Q+
Sbjct: 341 REQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRRE--QQLRREQQLRRE 398
Query: 129 APVRREQEAARRLREQEEAAQRERREELQRRRRLLDAAFDGDVGEIRAVLKEVEQLLTRE 188
+RREQ+ R +Q Q+ RRE+ RR + + E R + EQ R+
Sbjct: 399 QQLRREQQLRR--EQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRD 456
Query: 189 GVGHDEAGEARRLQRR 204
+ +E E +RR
Sbjct: 457 WLKREEETERHEQERR 472
Score = 33.1 bits (74), Expect = 0.72
Identities = 29/102 (28%), Positives = 47/102 (46%), Gaps = 16/102 (15%)
Query: 69 REPRLGRAGGFESRPAEDRAARAIQGAFRQLRARRELARRREER-REYLE---------- 117
RE + R + E+R + ++ + R +ELA +E+ RE ++
Sbjct: 649 REQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQL 708
Query: 118 --QMETPQKEAYLAPVRREQEAARRLREQEEAAQRERREELQ 157
+ + Q + Y P R+QE RR +EQEE +R R ELQ
Sbjct: 709 ESEADARQSKVYSRP--RKQEGQRRRQEQEE-KRRRRESELQ 747
Score = 29.6 bits (65), Expect = 8.0
Identities = 26/119 (21%), Positives = 54/119 (45%), Gaps = 10/119 (8%)
Query: 306 EAMLQNMEAEQQRRAQEAQRHKEAEAERMTLKVQQLTREQQQCHKELQQAYCELSRRISE 365
E L+ E EQQ R ++ +E E ++ Q EQQ +E + + E +++
Sbjct: 1649 EPQLRRQEREQQLRHDRDRKFREEE------QLLQEGEEQQLRRQERDRKFREEEQQLRR 1702
Query: 366 HDQCEWRCMDKTKLTLQAIKDTEAQVDRLRQEAQKAEEALAMARLELREQTQEGEEEAP 424
++ ++ +L Q ++ + ++LRQE ++ + + R E + E E+ P
Sbjct: 1703 QERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQ----LRRQERYRKILEEEQLRP 1757
>gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase 2 [Homo sapiens]
Length = 1166
Score = 55.1 bits (131), Expect = 2e-07
Identities = 41/135 (30%), Positives = 64/135 (47%), Gaps = 12/135 (8%)
Query: 160 RRLLDAAFDGDVGEIRAVLKEVEQLLTREGVG------HDEAGEARR-----LQRRVALA 208
R L +A +GDV ++ ++ E++ +R+ G H AG R+ L + A
Sbjct: 26 RELFEACRNGDVERVKRLVTP-EKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANV 84
Query: 209 ECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLL 268
+ D G PL A + G + L GA PN++ + TPL+ AA G + VLL
Sbjct: 85 QARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLL 144
Query: 269 KLGADPRVYAEDGST 283
+ GA+P + DG T
Sbjct: 145 QHGAEPTIRNTDGRT 159
Score = 50.8 bits (120), Expect = 3e-06
Identities = 47/160 (29%), Positives = 71/160 (44%), Gaps = 13/160 (8%)
Query: 160 RRLLDAAFDGDVGEIRAVLKEVEQLLTRE-----------GVGHDEAGEARRLQRRVALA 208
R+LL+AA GDV ++ L V+ + R+ G++ L + A
Sbjct: 494 RQLLEAAKAGDVETVKK-LCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADV 552
Query: 209 ECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLL 268
+D G PL A + G +L + GA N + TPL+ AA G ++LL
Sbjct: 553 HAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLL 612
Query: 269 KLGADPRVYAEDGSTP-ERVASLDTVVSVLRSWDLSLTEA 307
+ GADP DG+TP + V DT + L D +L +A
Sbjct: 613 QHGADPTKKNRDGNTPLDLVKDGDTDIQDLLRGDAALLDA 652
Score = 47.0 bits (110), Expect = 5e-05
Identities = 33/107 (30%), Positives = 49/107 (45%)
Query: 191 GHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPT 250
G++ A L + A +D G PL AA+ G L + A N+ + T
Sbjct: 688 GYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFT 747
Query: 251 PLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVASLDTVVSVL 297
PL+ AA G +LL GADP + ++G TP + S D V ++L
Sbjct: 748 PLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDLVSADDVSALL 794
Score = 42.4 bits (98), Expect = 0.001
Identities = 28/98 (28%), Positives = 46/98 (46%)
Query: 217 TPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADPRV 276
TPL A+ +++ + A N+ G T L+RAA+ GHL +LL G DP +
Sbjct: 402 TPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNI 461
Query: 277 YAEDGSTPERVASLDTVVSVLRSWDLSLTEAMLQNMEA 314
+ G T ++ + + + L +EA Q +EA
Sbjct: 462 ISLQGFTALQMGNENVQQLLQEGISLGNSEADRQLLEA 499
Score = 34.3 bits (77), Expect = 0.32
Identities = 21/61 (34%), Positives = 30/61 (49%)
Query: 212 DSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLG 271
D +TPL AA + +QL + GA ++K PL+ A GH E+L+K G
Sbjct: 208 DGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHG 267
Query: 272 A 272
A
Sbjct: 268 A 268
Score = 33.1 bits (74), Expect = 0.72
Identities = 23/84 (27%), Positives = 36/84 (42%)
Query: 191 GHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPT 250
G++ + L + A +D PL A + G +L + GA N+ + T
Sbjct: 220 GYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFT 279
Query: 251 PLYRAAFGGHLAAVEVLLKLGADP 274
PL+ AA + +LL GADP
Sbjct: 280 PLHEAASKNRVEVCSLLLSYGADP 303
>gi|30348954 mindbomb homolog 1 [Homo sapiens]
Length = 1006
Score = 53.5 bits (127), Expect = 5e-07
Identities = 39/143 (27%), Positives = 62/143 (43%), Gaps = 9/143 (6%)
Query: 151 ERREELQRRRRLLDAAFDGDVGEIRAVLKEVEQLLTREGVGHDEAGEARR---------L 201
E +E L+ AA +GDV ++ +LK + + + GH A + L
Sbjct: 424 ETQESGDLNEELVKAAANGDVAKVEDLLKRPDVDVNGQCAGHTAMQAASQNGHVDILKLL 483
Query: 202 QRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHL 261
++ E ED G+ + AA G + I++ A N++ TPL+ A GHL
Sbjct: 484 LKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHL 543
Query: 262 AAVEVLLKLGADPRVYAEDGSTP 284
V+ LL G P + +G TP
Sbjct: 544 QVVKTLLDFGCHPSLQDSEGDTP 566
Score = 35.4 bits (80), Expect = 0.14
Identities = 28/89 (31%), Positives = 43/89 (48%), Gaps = 3/89 (3%)
Query: 211 EDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKL 270
+DS G+TPL +A + + + + E GA G L+ AA G+ +A+ VLL
Sbjct: 559 QDSEGDTPLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPSAMRVLLSK 618
Query: 271 GADPRVYAE---DGSTPERVASLDTVVSV 296
P + E DG T +A+L+ V V
Sbjct: 619 LPRPWIVDEKKDDGYTALHLAALNNHVEV 647
>gi|90186267 ankyrin repeat domain 55 isoform 1 [Homo sapiens]
Length = 614
Score = 53.5 bits (127), Expect = 5e-07
Identities = 45/173 (26%), Positives = 74/173 (42%), Gaps = 23/173 (13%)
Query: 165 AAFDGDVGEIRAVLKEVEQLLTREGVGHDEAGEARRLQRRVALAECEDSYGNTPLSEAAA 224
AA +GDV + AV++E +L EC DS G TPL A +
Sbjct: 34 AASNGDVNALTAVIREDPSIL-----------------------ECCDSEGCTPLMHAVS 70
Query: 225 GGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTP 284
G Q ++L ++GA+ N + A+G T L A + G L LL+ GA + ++G P
Sbjct: 71 GRQADTVKLLLKMGANINMQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLP 130
Query: 285 ERVASLDTVVSVLRSWDLSLTEAMLQNMEAEQQRRAQEAQRHKEAEAERMTLK 337
A+ + + +L + + + + E A H + + +M LK
Sbjct: 131 LHAATAEPDMRLLTVLLQQSNISEINHQDNEGMTPLHWAAFHNQPQHTQMLLK 183
Score = 37.0 bits (84), Expect = 0.050
Identities = 26/77 (33%), Positives = 35/77 (45%), Gaps = 4/77 (5%)
Query: 195 AGEARRLQRRVALAECE----DSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPT 250
AG + + + EC D TPL AAA G+ +Q ELG N + T
Sbjct: 241 AGFSDIIHELARVPECNLQALDVDDRTPLHWAAAAGKAECVQSLLELGMDSNLRDINEST 300
Query: 251 PLYRAAFGGHLAAVEVL 267
PL A + GH A V++L
Sbjct: 301 PLAYALYCGHTACVKLL 317
Score = 30.4 bits (67), Expect = 4.7
Identities = 31/140 (22%), Positives = 55/140 (39%), Gaps = 4/140 (2%)
Query: 202 QRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHL 261
Q ++ +D+ G TPL AA QP Q+ + GA P T L+ A G+
Sbjct: 149 QSNISEINHQDNEGMTPLHWAAFHNQPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNR 208
Query: 262 AAVEVLLKLGADPRVY---AEDGSTPERVASLDTVVSVLRSWDLSLTEAMLQNMEAEQQR 318
++L P + E G T +A+ ++ + E LQ ++ + +
Sbjct: 209 ILCSIILSHHQGPSIINYDDESGKTCVHIAAAAGFSDIIHEL-ARVPECNLQALDVDDRT 267
Query: 319 RAQEAQRHKEAEAERMTLKV 338
A +AE + L++
Sbjct: 268 PLHWAAAAGKAECVQSLLEL 287
>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
Length = 1863
Score = 53.1 bits (126), Expect = 7e-07
Identities = 35/98 (35%), Positives = 50/98 (51%), Gaps = 2/98 (2%)
Query: 191 GHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPT 250
GH G + L R + + GNT L A+ GQ +++ + GA+ N++ G T
Sbjct: 54 GH--VGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFT 111
Query: 251 PLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVA 288
PLY AA H+ V+ LL+ GA+ EDG TP VA
Sbjct: 112 PLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVA 149
Score = 48.5 bits (114), Expect = 2e-05
Identities = 33/105 (31%), Positives = 49/105 (46%)
Query: 193 DEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPL 252
D+ A L + A + G TPL A G + + GA+ N+K G TPL
Sbjct: 685 DKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPL 744
Query: 253 YRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVASLDTVVSVL 297
++AA GH + VLL+ GA P +G+T +A +SV+
Sbjct: 745 HQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVV 789
Score = 47.4 bits (111), Expect = 4e-05
Identities = 32/92 (34%), Positives = 43/92 (46%)
Query: 198 ARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAF 257
A+ L +R A A+ G TPL AA L E GASP++ G TPL+ AA
Sbjct: 558 AKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAK 617
Query: 258 GGHLAAVEVLLKLGADPRVYAEDGSTPERVAS 289
+ LL GA+ + + G TP +AS
Sbjct: 618 KNQMQIASTLLNYGAETNIVTKQGVTPLHLAS 649
Score = 45.1 bits (105), Expect = 2e-04
Identities = 39/123 (31%), Positives = 58/123 (47%), Gaps = 2/123 (1%)
Query: 215 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADP 274
G TPL A + ++L + GAS + G TP++ AAF GHL V +LL+ GA P
Sbjct: 377 GFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASP 436
Query: 275 RVYAEDGSTPERVASLDTVVSVLRSWDLSLTEAMLQNMEAEQQRRAQEAQRHKEAEAERM 334
V G T +A+ V V+R L A++ E+Q A R + E ++
Sbjct: 437 DVTNIRGETALHMAARAGQVEVVRC--LLRNGALVDARAREEQTPLHIASRLGKTEIVQL 494
Query: 335 TLK 337
L+
Sbjct: 495 LLQ 497
Score = 43.5 bits (101), Expect = 5e-04
Identities = 38/140 (27%), Positives = 61/140 (43%), Gaps = 2/140 (1%)
Query: 152 RREELQRRRRLLDAAFDGDVGEIRAVLKEVEQLLTREGVG--HDEAGEARRLQRRVALAE 209
R+++ + LL + DV V + E T + + A L R A +
Sbjct: 180 RKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVD 239
Query: 210 CEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLK 269
G TPL A+ G ++L + G ++K G TPL+ AA GH VE+LL+
Sbjct: 240 FTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLE 299
Query: 270 LGADPRVYAEDGSTPERVAS 289
GA ++G +P +A+
Sbjct: 300 RGAPLLARTKNGLSPLHMAA 319
Score = 41.2 bits (95), Expect = 0.003
Identities = 30/91 (32%), Positives = 44/91 (48%)
Query: 199 RRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFG 258
R L R AL + TPL A+ G+ +QL + A P++ G TPL+ +A
Sbjct: 460 RCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISARE 519
Query: 259 GHLAAVEVLLKLGADPRVYAEDGSTPERVAS 289
G + VLL+ GA + + G TP VA+
Sbjct: 520 GQVDVASVLLEAGAAHSLATKKGFTPLHVAA 550
Score = 40.8 bits (94), Expect = 0.003
Identities = 27/75 (36%), Positives = 39/75 (52%)
Query: 215 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADP 274
G TPL AA G +L + A+ +S G G TPL+ AA + +LL+ GA P
Sbjct: 542 GFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASP 601
Query: 275 RVYAEDGSTPERVAS 289
A++G TP +A+
Sbjct: 602 HATAKNGYTPLHIAA 616
Score = 40.0 bits (92), Expect = 0.006
Identities = 25/73 (34%), Positives = 37/73 (50%)
Query: 217 TPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADPRV 276
T L AA G +L + A+PN++ G TPL+ A + +E+L+K GA +
Sbjct: 346 TALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQA 405
Query: 277 YAEDGSTPERVAS 289
E G TP VA+
Sbjct: 406 ITESGLTPIHVAA 418
Score = 37.0 bits (84), Expect = 0.050
Identities = 27/82 (32%), Positives = 37/82 (45%)
Query: 215 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADP 274
G TPL AA Q GA N G TPL+ A+ GH V +LL GA+
Sbjct: 608 GYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANI 667
Query: 275 RVYAEDGSTPERVASLDTVVSV 296
+ + G T +A+ + V+V
Sbjct: 668 HMSTKSGLTSLHLAAQEDKVNV 689
Score = 36.2 bits (82), Expect = 0.085
Identities = 25/84 (29%), Positives = 42/84 (50%)
Query: 215 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADP 274
G L AA G +Q G+S +S G T L+ A+ G V+VL+K GA+
Sbjct: 43 GLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANI 102
Query: 275 RVYAEDGSTPERVASLDTVVSVLR 298
+++G TP +A+ + + V++
Sbjct: 103 NAQSQNGFTPLYMAAQENHIDVVK 126
Score = 35.4 bits (80), Expect = 0.14
Identities = 28/89 (31%), Positives = 43/89 (48%)
Query: 201 LQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGH 260
L + +A + + G TPL +A GQ + E GA+ + G TPL+ AA G
Sbjct: 495 LLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGS 554
Query: 261 LAAVEVLLKLGADPRVYAEDGSTPERVAS 289
L ++LL+ A ++G TP VA+
Sbjct: 555 LDVAKLLLQRRAAADSAGKNGLTPLHVAA 583
Score = 34.7 bits (78), Expect = 0.25
Identities = 21/55 (38%), Positives = 30/55 (54%)
Query: 215 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLK 269
G TPL AA G ++L E GA ++ G +PL+ AA G H+ V+ LL+
Sbjct: 278 GLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQ 332
Score = 34.3 bits (77), Expect = 0.32
Identities = 24/82 (29%), Positives = 39/82 (47%)
Query: 215 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADP 274
G T L AA GQ ++ GA +++ TPL+ A+ G V++LL+ A P
Sbjct: 443 GETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHP 502
Query: 275 RVYAEDGSTPERVASLDTVVSV 296
+G TP +++ + V V
Sbjct: 503 DAATTNGYTPLHISAREGQVDV 524
Score = 34.3 bits (77), Expect = 0.32
Identities = 29/117 (24%), Positives = 51/117 (43%), Gaps = 15/117 (12%)
Query: 201 LQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGH 260
L ++ A + G TPL +AA G I + + GA PN+ A G T L A G+
Sbjct: 726 LLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGY 785
Query: 261 LAAVEVLLKLGADPRVYAEDGSTPERVASLDTVVSVLRSWDLSLTEAMLQNMEAEQQ 317
++ V+ L +V E+ +T T ++ L++ E M + ++ +
Sbjct: 786 ISVVDTL-------KVVTEEVTT--------TTTTITEKHKLNVPETMTEVLDVSDE 827
Score = 33.1 bits (74), Expect = 0.72
Identities = 24/74 (32%), Positives = 35/74 (47%)
Query: 215 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADP 274
G TPL A+ G + L + GA+ + G T L+ AA + ++L K GAD
Sbjct: 641 GVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQ 700
Query: 275 RVYAEDGSTPERVA 288
+ + G TP VA
Sbjct: 701 DAHTKLGYTPLIVA 714
Score = 32.3 bits (72), Expect = 1.2
Identities = 30/107 (28%), Positives = 44/107 (41%), Gaps = 2/107 (1%)
Query: 191 GHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPT 250
GHD+ E L R A G +PL AA G ++ + A + T
Sbjct: 289 GHDQVVEL--LLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLT 346
Query: 251 PLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVASLDTVVSVL 297
L+ AA GH ++LL A+P A +G TP +A + V+
Sbjct: 347 ALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVM 393
Score = 32.0 bits (71), Expect = 1.6
Identities = 22/70 (31%), Positives = 32/70 (45%)
Query: 215 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADP 274
G T L AA + + + GA ++ G TPL A G++ V LLK GA+
Sbjct: 674 GLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANV 733
Query: 275 RVYAEDGSTP 284
++G TP
Sbjct: 734 NAKTKNGYTP 743
>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
Length = 1872
Score = 53.1 bits (126), Expect = 7e-07
Identities = 35/98 (35%), Positives = 50/98 (51%), Gaps = 2/98 (2%)
Query: 191 GHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPT 250
GH G + L R + + GNT L A+ GQ +++ + GA+ N++ G T
Sbjct: 75 GH--VGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFT 132
Query: 251 PLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVA 288
PLY AA H+ V+ LL+ GA+ EDG TP VA
Sbjct: 133 PLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVA 170
Score = 48.5 bits (114), Expect = 2e-05
Identities = 33/105 (31%), Positives = 49/105 (46%)
Query: 193 DEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPL 252
D+ A L + A + G TPL A G + + GA+ N+K G TPL
Sbjct: 706 DKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPL 765
Query: 253 YRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVASLDTVVSVL 297
++AA GH + VLL+ GA P +G+T +A +SV+
Sbjct: 766 HQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVV 810
Score = 47.4 bits (111), Expect = 4e-05
Identities = 32/92 (34%), Positives = 43/92 (46%)
Query: 198 ARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAF 257
A+ L +R A A+ G TPL AA L E GASP++ G TPL+ AA
Sbjct: 579 AKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAK 638
Query: 258 GGHLAAVEVLLKLGADPRVYAEDGSTPERVAS 289
+ LL GA+ + + G TP +AS
Sbjct: 639 KNQMQIASTLLNYGAETNIVTKQGVTPLHLAS 670
Score = 45.1 bits (105), Expect = 2e-04
Identities = 39/123 (31%), Positives = 58/123 (47%), Gaps = 2/123 (1%)
Query: 215 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADP 274
G TPL A + ++L + GAS + G TP++ AAF GHL V +LL+ GA P
Sbjct: 398 GFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASP 457
Query: 275 RVYAEDGSTPERVASLDTVVSVLRSWDLSLTEAMLQNMEAEQQRRAQEAQRHKEAEAERM 334
V G T +A+ V V+R L A++ E+Q A R + E ++
Sbjct: 458 DVTNIRGETALHMAARAGQVEVVRC--LLRNGALVDARAREEQTPLHIASRLGKTEIVQL 515
Query: 335 TLK 337
L+
Sbjct: 516 LLQ 518
Score = 43.5 bits (101), Expect = 5e-04
Identities = 38/140 (27%), Positives = 61/140 (43%), Gaps = 2/140 (1%)
Query: 152 RREELQRRRRLLDAAFDGDVGEIRAVLKEVEQLLTREGVG--HDEAGEARRLQRRVALAE 209
R+++ + LL + DV V + E T + + A L R A +
Sbjct: 201 RKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVD 260
Query: 210 CEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLK 269
G TPL A+ G ++L + G ++K G TPL+ AA GH VE+LL+
Sbjct: 261 FTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLE 320
Query: 270 LGADPRVYAEDGSTPERVAS 289
GA ++G +P +A+
Sbjct: 321 RGAPLLARTKNGLSPLHMAA 340
Score = 41.2 bits (95), Expect = 0.003
Identities = 30/91 (32%), Positives = 44/91 (48%)
Query: 199 RRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFG 258
R L R AL + TPL A+ G+ +QL + A P++ G TPL+ +A
Sbjct: 481 RCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISARE 540
Query: 259 GHLAAVEVLLKLGADPRVYAEDGSTPERVAS 289
G + VLL+ GA + + G TP VA+
Sbjct: 541 GQVDVASVLLEAGAAHSLATKKGFTPLHVAA 571
Score = 40.8 bits (94), Expect = 0.003
Identities = 27/75 (36%), Positives = 39/75 (52%)
Query: 215 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADP 274
G TPL AA G +L + A+ +S G G TPL+ AA + +LL+ GA P
Sbjct: 563 GFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASP 622
Query: 275 RVYAEDGSTPERVAS 289
A++G TP +A+
Sbjct: 623 HATAKNGYTPLHIAA 637
Score = 40.0 bits (92), Expect = 0.006
Identities = 25/73 (34%), Positives = 37/73 (50%)
Query: 217 TPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADPRV 276
T L AA G +L + A+PN++ G TPL+ A + +E+L+K GA +
Sbjct: 367 TALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQA 426
Query: 277 YAEDGSTPERVAS 289
E G TP VA+
Sbjct: 427 ITESGLTPIHVAA 439
Score = 37.0 bits (84), Expect = 0.050
Identities = 27/82 (32%), Positives = 37/82 (45%)
Query: 215 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADP 274
G TPL AA Q GA N G TPL+ A+ GH V +LL GA+
Sbjct: 629 GYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANI 688
Query: 275 RVYAEDGSTPERVASLDTVVSV 296
+ + G T +A+ + V+V
Sbjct: 689 HMSTKSGLTSLHLAAQEDKVNV 710
Score = 36.2 bits (82), Expect = 0.085
Identities = 25/84 (29%), Positives = 42/84 (50%)
Query: 215 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADP 274
G L AA G +Q G+S +S G T L+ A+ G V+VL+K GA+
Sbjct: 64 GLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANI 123
Query: 275 RVYAEDGSTPERVASLDTVVSVLR 298
+++G TP +A+ + + V++
Sbjct: 124 NAQSQNGFTPLYMAAQENHIDVVK 147
Score = 35.4 bits (80), Expect = 0.14
Identities = 28/89 (31%), Positives = 43/89 (48%)
Query: 201 LQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGH 260
L + +A + + G TPL +A GQ + E GA+ + G TPL+ AA G
Sbjct: 516 LLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGS 575
Query: 261 LAAVEVLLKLGADPRVYAEDGSTPERVAS 289
L ++LL+ A ++G TP VA+
Sbjct: 576 LDVAKLLLQRRAAADSAGKNGLTPLHVAA 604
Score = 34.7 bits (78), Expect = 0.25
Identities = 21/55 (38%), Positives = 30/55 (54%)
Query: 215 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLK 269
G TPL AA G ++L E GA ++ G +PL+ AA G H+ V+ LL+
Sbjct: 299 GLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQ 353
Score = 34.3 bits (77), Expect = 0.32
Identities = 24/82 (29%), Positives = 39/82 (47%)
Query: 215 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADP 274
G T L AA GQ ++ GA +++ TPL+ A+ G V++LL+ A P
Sbjct: 464 GETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHP 523
Query: 275 RVYAEDGSTPERVASLDTVVSV 296
+G TP +++ + V V
Sbjct: 524 DAATTNGYTPLHISAREGQVDV 545
Score = 34.3 bits (77), Expect = 0.32
Identities = 29/117 (24%), Positives = 51/117 (43%), Gaps = 15/117 (12%)
Query: 201 LQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGH 260
L ++ A + G TPL +AA G I + + GA PN+ A G T L A G+
Sbjct: 747 LLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGY 806
Query: 261 LAAVEVLLKLGADPRVYAEDGSTPERVASLDTVVSVLRSWDLSLTEAMLQNMEAEQQ 317
++ V+ L +V E+ +T T ++ L++ E M + ++ +
Sbjct: 807 ISVVDTL-------KVVTEEVTT--------TTTTITEKHKLNVPETMTEVLDVSDE 848
Score = 33.1 bits (74), Expect = 0.72
Identities = 24/74 (32%), Positives = 35/74 (47%)
Query: 215 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADP 274
G TPL A+ G + L + GA+ + G T L+ AA + ++L K GAD
Sbjct: 662 GVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQ 721
Query: 275 RVYAEDGSTPERVA 288
+ + G TP VA
Sbjct: 722 DAHTKLGYTPLIVA 735
Score = 32.3 bits (72), Expect = 1.2
Identities = 30/107 (28%), Positives = 44/107 (41%), Gaps = 2/107 (1%)
Query: 191 GHDEAGEARRLQRRVALAECEDSYGNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPT 250
GHD+ E L R A G +PL AA G ++ + A + T
Sbjct: 310 GHDQVVEL--LLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLT 367
Query: 251 PLYRAAFGGHLAAVEVLLKLGADPRVYAEDGSTPERVASLDTVVSVL 297
L+ AA GH ++LL A+P A +G TP +A + V+
Sbjct: 368 ALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVM 414
Score = 32.0 bits (71), Expect = 1.6
Identities = 22/70 (31%), Positives = 32/70 (45%)
Query: 215 GNTPLSEAAAGGQPLAIQLRAELGASPNSKGAFGPTPLYRAAFGGHLAAVEVLLKLGADP 274
G T L AA + + + GA ++ G TPL A G++ V LLK GA+
Sbjct: 695 GLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANV 754
Query: 275 RVYAEDGSTP 284
++G TP
Sbjct: 755 NAKTKNGYTP 764
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.133 0.384
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,161,607
Number of Sequences: 37866
Number of extensions: 1175285
Number of successful extensions: 15605
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 467
Number of HSP's successfully gapped in prelim test: 645
Number of HSP's that attempted gapping in prelim test: 7294
Number of HSP's gapped (non-prelim): 5760
length of query: 580
length of database: 18,247,518
effective HSP length: 108
effective length of query: 472
effective length of database: 14,157,990
effective search space: 6682571280
effective search space used: 6682571280
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.