Guide to the Human Genome
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Search of human proteins with 239743307

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|239743307 PREDICTED: similar to calcium-promoted Ras
inactivator isoform 1 [Homo sapiens]
         (757 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|239743307 PREDICTED: similar to calcium-promoted Ras inactiva...  1529   0.0  
gi|239508990 PREDICTED: similar to calcium-promoted Ras inactiva...  1529   0.0  
gi|121114292 RAS p21 protein activator 4 isoform 2 [Homo sapiens]    1521   0.0  
gi|121114294 RAS p21 protein activator 4 isoform 1 [Homo sapiens]    1499   0.0  
gi|239743309 PREDICTED: similar to calcium-promoted Ras inactiva...  1356   0.0  
gi|239508992 PREDICTED: similar to calcium-promoted Ras inactiva...  1356   0.0  
gi|4759026 RAS protein activator like 1 [Homo sapiens]                674   0.0  
gi|38201692 RAS p21 protein activator 3 [Homo sapiens]                301   1e-81
gi|12545408 RAS p21 protein activator 2 [Homo sapiens]                300   4e-81
gi|226958575 RAS protein activator like 2 isoform 2 [Homo sapiens]    132   9e-31
gi|4758808 RAS protein activator like 2 isoform 1 [Homo sapiens]      132   9e-31
gi|41281683 disabled homolog 2 interacting protein isoform 2 [Ho...   118   2e-26
gi|94967023 disabled homolog 2 interacting protein isoform 1 [Ho...   118   2e-26
gi|194248068 synaptic Ras GTPase activating protein 1 [Homo sapi...   115   1e-25
gi|4506431 RAS p21 protein activator 1 isoform 1 [Homo sapiens]       105   1e-22
gi|12545406 RAS p21 protein activator 1 isoform 2 [Homo sapiens]      105   1e-22
gi|38570146 synaptotagmin VII [Homo sapiens]                           90   7e-18
gi|238550198 synaptotagmin III [Homo sapiens]                          90   9e-18
gi|238550196 synaptotagmin III [Homo sapiens]                          90   9e-18
gi|14150054 synaptotagmin III [Homo sapiens]                           90   9e-18
gi|130502162 RAS protein activator like 3 [Homo sapiens]               87   6e-17
gi|209447073 synaptotagmin I [Homo sapiens]                            86   2e-16
gi|5032139 synaptotagmin I [Homo sapiens]                              86   2e-16
gi|209447070 synaptotagmin I [Homo sapiens]                            86   2e-16
gi|45504376 synaptotagmin VI [Homo sapiens]                            85   2e-16
gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens]            84   5e-16
gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens]            84   5e-16
gi|92859638 synaptotagmin V [Homo sapiens]                             84   5e-16
gi|28376627 synaptotagmin IX [Homo sapiens]                            82   1e-15
gi|13384594 protein kinase C, gamma [Homo sapiens]                     81   3e-15

>gi|239743307 PREDICTED: similar to calcium-promoted Ras inactivator
           isoform 1 [Homo sapiens]
          Length = 757

 Score = 1529 bits (3958), Expect = 0.0
 Identities = 757/757 (100%), Positives = 757/757 (100%)

Query: 1   MAKRSSLYIRIVEGKNLPAKDITGSSDPYCIVKVDNEPIIRTATVWKTLCPFWGEEYQVH 60
           MAKRSSLYIRIVEGKNLPAKDITGSSDPYCIVKVDNEPIIRTATVWKTLCPFWGEEYQVH
Sbjct: 1   MAKRSSLYIRIVEGKNLPAKDITGSSDPYCIVKVDNEPIIRTATVWKTLCPFWGEEYQVH 60

Query: 61  LPPTFHAVAFYVMDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEI 120
           LPPTFHAVAFYVMDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEI
Sbjct: 61  LPPTFHAVAFYVMDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEI 120

Query: 121 HLRLEVWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRW 180
           HLRLEVWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRW
Sbjct: 121 HLRLEVWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRW 180

Query: 181 NETFEFELQEGAMEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSK 240
           NETFEFELQEGAMEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSK
Sbjct: 181 NETFEFELQEGAMEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSK 240

Query: 241 SRRHDEGNLGSLQLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTST 300
           SRRHDEGNLGSLQLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTST
Sbjct: 241 SRRHDEGNLGSLQLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTST 300

Query: 301 ECRQDVATNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSVESFLKVAG 360
           ECRQDVATNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSVESFLKVAG
Sbjct: 301 ECRQDVATNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSVESFLKVAG 360

Query: 361 MQYLHGVLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHL 420
           MQYLHGVLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHL
Sbjct: 361 MQYLHGVLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHL 420

Query: 421 GALLSALSRSVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIM 480
           GALLSALSRSVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIM
Sbjct: 421 GALLSALSRSVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIM 480

Query: 481 SPKLFHLRERHADARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVHQGVAQLK 540
           SPKLFHLRERHADARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVHQGVAQLK
Sbjct: 481 SPKLFHLRERHADARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVHQGVAQLK 540

Query: 541 DFITKLVDIEEKDELDLQRTLSLQAPPVKEGPLFIHRTKGKGPLMSSSFKKLYFSLTTEA 600
           DFITKLVDIEEKDELDLQRTLSLQAPPVKEGPLFIHRTKGKGPLMSSSFKKLYFSLTTEA
Sbjct: 541 DFITKLVDIEEKDELDLQRTLSLQAPPVKEGPLFIHRTKGKGPLMSSSFKKLYFSLTTEA 600

Query: 601 LSFAKTPSSKCVNELNQWLSALRKVSINNTGLLGSYHPGVFRGDKWSCCHQKEKTGQGCD 660
           LSFAKTPSSKCVNELNQWLSALRKVSINNTGLLGSYHPGVFRGDKWSCCHQKEKTGQGCD
Sbjct: 601 LSFAKTPSSKCVNELNQWLSALRKVSINNTGLLGSYHPGVFRGDKWSCCHQKEKTGQGCD 660

Query: 661 KTRSRVTLQEWNDPLDHDLEAQLIYRHLLGVEAMLWERHRELSGGAEAGTVPTSPGKVPE 720
           KTRSRVTLQEWNDPLDHDLEAQLIYRHLLGVEAMLWERHRELSGGAEAGTVPTSPGKVPE
Sbjct: 661 KTRSRVTLQEWNDPLDHDLEAQLIYRHLLGVEAMLWERHRELSGGAEAGTVPTSPGKVPE 720

Query: 721 DSLARLLRVLQDLREAHSSSPAGSPPSEPNCLLELQT 757
           DSLARLLRVLQDLREAHSSSPAGSPPSEPNCLLELQT
Sbjct: 721 DSLARLLRVLQDLREAHSSSPAGSPPSEPNCLLELQT 757


>gi|239508990 PREDICTED: similar to calcium-promoted Ras inactivator
           isoform 2 [Homo sapiens]
          Length = 757

 Score = 1529 bits (3958), Expect = 0.0
 Identities = 757/757 (100%), Positives = 757/757 (100%)

Query: 1   MAKRSSLYIRIVEGKNLPAKDITGSSDPYCIVKVDNEPIIRTATVWKTLCPFWGEEYQVH 60
           MAKRSSLYIRIVEGKNLPAKDITGSSDPYCIVKVDNEPIIRTATVWKTLCPFWGEEYQVH
Sbjct: 1   MAKRSSLYIRIVEGKNLPAKDITGSSDPYCIVKVDNEPIIRTATVWKTLCPFWGEEYQVH 60

Query: 61  LPPTFHAVAFYVMDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEI 120
           LPPTFHAVAFYVMDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEI
Sbjct: 61  LPPTFHAVAFYVMDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEI 120

Query: 121 HLRLEVWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRW 180
           HLRLEVWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRW
Sbjct: 121 HLRLEVWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRW 180

Query: 181 NETFEFELQEGAMEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSK 240
           NETFEFELQEGAMEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSK
Sbjct: 181 NETFEFELQEGAMEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSK 240

Query: 241 SRRHDEGNLGSLQLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTST 300
           SRRHDEGNLGSLQLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTST
Sbjct: 241 SRRHDEGNLGSLQLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTST 300

Query: 301 ECRQDVATNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSVESFLKVAG 360
           ECRQDVATNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSVESFLKVAG
Sbjct: 301 ECRQDVATNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSVESFLKVAG 360

Query: 361 MQYLHGVLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHL 420
           MQYLHGVLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHL
Sbjct: 361 MQYLHGVLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHL 420

Query: 421 GALLSALSRSVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIM 480
           GALLSALSRSVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIM
Sbjct: 421 GALLSALSRSVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIM 480

Query: 481 SPKLFHLRERHADARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVHQGVAQLK 540
           SPKLFHLRERHADARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVHQGVAQLK
Sbjct: 481 SPKLFHLRERHADARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVHQGVAQLK 540

Query: 541 DFITKLVDIEEKDELDLQRTLSLQAPPVKEGPLFIHRTKGKGPLMSSSFKKLYFSLTTEA 600
           DFITKLVDIEEKDELDLQRTLSLQAPPVKEGPLFIHRTKGKGPLMSSSFKKLYFSLTTEA
Sbjct: 541 DFITKLVDIEEKDELDLQRTLSLQAPPVKEGPLFIHRTKGKGPLMSSSFKKLYFSLTTEA 600

Query: 601 LSFAKTPSSKCVNELNQWLSALRKVSINNTGLLGSYHPGVFRGDKWSCCHQKEKTGQGCD 660
           LSFAKTPSSKCVNELNQWLSALRKVSINNTGLLGSYHPGVFRGDKWSCCHQKEKTGQGCD
Sbjct: 601 LSFAKTPSSKCVNELNQWLSALRKVSINNTGLLGSYHPGVFRGDKWSCCHQKEKTGQGCD 660

Query: 661 KTRSRVTLQEWNDPLDHDLEAQLIYRHLLGVEAMLWERHRELSGGAEAGTVPTSPGKVPE 720
           KTRSRVTLQEWNDPLDHDLEAQLIYRHLLGVEAMLWERHRELSGGAEAGTVPTSPGKVPE
Sbjct: 661 KTRSRVTLQEWNDPLDHDLEAQLIYRHLLGVEAMLWERHRELSGGAEAGTVPTSPGKVPE 720

Query: 721 DSLARLLRVLQDLREAHSSSPAGSPPSEPNCLLELQT 757
           DSLARLLRVLQDLREAHSSSPAGSPPSEPNCLLELQT
Sbjct: 721 DSLARLLRVLQDLREAHSSSPAGSPPSEPNCLLELQT 757


>gi|121114292 RAS p21 protein activator 4 isoform 2 [Homo sapiens]
          Length = 757

 Score = 1521 bits (3938), Expect = 0.0
 Identities = 754/757 (99%), Positives = 755/757 (99%)

Query: 1   MAKRSSLYIRIVEGKNLPAKDITGSSDPYCIVKVDNEPIIRTATVWKTLCPFWGEEYQVH 60
           MAKRSSLYIRIVEGKNLPAKDITGSSDPYCIVKVDNEPIIRTATVWKTLCPFWGEEYQVH
Sbjct: 1   MAKRSSLYIRIVEGKNLPAKDITGSSDPYCIVKVDNEPIIRTATVWKTLCPFWGEEYQVH 60

Query: 61  LPPTFHAVAFYVMDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEI 120
           LPPTFHAVAFYVMDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEI
Sbjct: 61  LPPTFHAVAFYVMDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEI 120

Query: 121 HLRLEVWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRW 180
           HLRLEVWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRW
Sbjct: 121 HLRLEVWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRW 180

Query: 181 NETFEFELQEGAMEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSK 240
           NETFEFELQEGAMEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSK
Sbjct: 181 NETFEFELQEGAMEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSK 240

Query: 241 SRRHDEGNLGSLQLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTST 300
           SRRHDEGNLGSLQLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTST
Sbjct: 241 SRRHDEGNLGSLQLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTST 300

Query: 301 ECRQDVATNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSVESFLKVAG 360
           ECRQDVATNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKS+ESFLKVAG
Sbjct: 301 ECRQDVATNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSMESFLKVAG 360

Query: 361 MQYLHGVLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHL 420
           MQYLHGVLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHL
Sbjct: 361 MQYLHGVLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHL 420

Query: 421 GALLSALSRSVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIM 480
           GALLSALSRSVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIM
Sbjct: 421 GALLSALSRSVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIM 480

Query: 481 SPKLFHLRERHADARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVHQGVAQLK 540
           SPKLFHLRERHADARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTV QGVAQLK
Sbjct: 481 SPKLFHLRERHADARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVRQGVAQLK 540

Query: 541 DFITKLVDIEEKDELDLQRTLSLQAPPVKEGPLFIHRTKGKGPLMSSSFKKLYFSLTTEA 600
           DFITKLVDIEEKDELDLQRTLSLQAPPVKEGPLFIHRTKGKGPLMSSSFKKLYFSLTTEA
Sbjct: 541 DFITKLVDIEEKDELDLQRTLSLQAPPVKEGPLFIHRTKGKGPLMSSSFKKLYFSLTTEA 600

Query: 601 LSFAKTPSSKCVNELNQWLSALRKVSINNTGLLGSYHPGVFRGDKWSCCHQKEKTGQGCD 660
           LSFAKTPSSKCVNELNQWLSALRKVSINNTGLLGSYHPGVFRGDKWSCCHQKEKTGQGCD
Sbjct: 601 LSFAKTPSSKCVNELNQWLSALRKVSINNTGLLGSYHPGVFRGDKWSCCHQKEKTGQGCD 660

Query: 661 KTRSRVTLQEWNDPLDHDLEAQLIYRHLLGVEAMLWERHRELSGGAEAGTVPTSPGKVPE 720
           KTRSRVTLQEWNDPLDHDLEAQLI RHLLGVEAMLWERHRELSGGAEAGTVPTSPGKVPE
Sbjct: 661 KTRSRVTLQEWNDPLDHDLEAQLICRHLLGVEAMLWERHRELSGGAEAGTVPTSPGKVPE 720

Query: 721 DSLARLLRVLQDLREAHSSSPAGSPPSEPNCLLELQT 757
           DSLARLLRVLQDLREAHSSSPAGSPPSEPNCLLELQT
Sbjct: 721 DSLARLLRVLQDLREAHSSSPAGSPPSEPNCLLELQT 757


>gi|121114294 RAS p21 protein activator 4 isoform 1 [Homo sapiens]
          Length = 803

 Score = 1499 bits (3881), Expect = 0.0
 Identities = 754/803 (93%), Positives = 755/803 (94%), Gaps = 46/803 (5%)

Query: 1   MAKRSSLYIRIVEGKNLPAKDITGSSDPYCIVKVDNEPIIRTATVWKTLCPFWGEEYQVH 60
           MAKRSSLYIRIVEGKNLPAKDITGSSDPYCIVKVDNEPIIRTATVWKTLCPFWGEEYQVH
Sbjct: 1   MAKRSSLYIRIVEGKNLPAKDITGSSDPYCIVKVDNEPIIRTATVWKTLCPFWGEEYQVH 60

Query: 61  LPPTFHAVAFYVMDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEI 120
           LPPTFHAVAFYVMDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEI
Sbjct: 61  LPPTFHAVAFYVMDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEI 120

Query: 121 HLRLEVWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRW 180
           HLRLEVWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRW
Sbjct: 121 HLRLEVWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRW 180

Query: 181 NETFEFELQEGAMEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSK 240
           NETFEFELQEGAMEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSK
Sbjct: 181 NETFEFELQEGAMEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSK 240

Query: 241 SRRHDEGNLGSLQLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTST 300
           SRRHDEGNLGSLQLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTST
Sbjct: 241 SRRHDEGNLGSLQLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTST 300

Query: 301 ECRQDVATNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSVESFLKVAG 360
           ECRQDVATNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKS+ESFLKVAG
Sbjct: 301 ECRQDVATNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSMESFLKVAG 360

Query: 361 MQYLHGVLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHL 420
           MQYLHGVLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHL
Sbjct: 361 MQYLHGVLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHL 420

Query: 421 GALLSALSRSVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIM 480
           GALLSALSRSVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIM
Sbjct: 421 GALLSALSRSVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIM 480

Query: 481 SPKLFHLRERHADARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVHQGVAQLK 540
           SPKLFHLRERHADARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTV QGVAQLK
Sbjct: 481 SPKLFHLRERHADARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVRQGVAQLK 540

Query: 541 DFITKLVDIEEKDELDLQRTLSLQAPPVKEGPLFIHRTKGKGPLMSSSFKKLYFSLTTEA 600
           DFITKLVDIEEKDELDLQRTLSLQAPPVKEGPLFIHRTKGKGPLMSSSFKKLYFSLTTEA
Sbjct: 541 DFITKLVDIEEKDELDLQRTLSLQAPPVKEGPLFIHRTKGKGPLMSSSFKKLYFSLTTEA 600

Query: 601 LSFAKTPSS----------------------------------------------KCVNE 614
           LSFAKTPSS                                              KCVNE
Sbjct: 601 LSFAKTPSSKKSALIKLANIRAAEKVEEKSFGGSHVMQVIYTDDAGRPQTAYLQCKCVNE 660

Query: 615 LNQWLSALRKVSINNTGLLGSYHPGVFRGDKWSCCHQKEKTGQGCDKTRSRVTLQEWNDP 674
           LNQWLSALRKVSINNTGLLGSYHPGVFRGDKWSCCHQKEKTGQGCDKTRSRVTLQEWNDP
Sbjct: 661 LNQWLSALRKVSINNTGLLGSYHPGVFRGDKWSCCHQKEKTGQGCDKTRSRVTLQEWNDP 720

Query: 675 LDHDLEAQLIYRHLLGVEAMLWERHRELSGGAEAGTVPTSPGKVPEDSLARLLRVLQDLR 734
           LDHDLEAQLI RHLLGVEAMLWERHRELSGGAEAGTVPTSPGKVPEDSLARLLRVLQDLR
Sbjct: 721 LDHDLEAQLICRHLLGVEAMLWERHRELSGGAEAGTVPTSPGKVPEDSLARLLRVLQDLR 780

Query: 735 EAHSSSPAGSPPSEPNCLLELQT 757
           EAHSSSPAGSPPSEPNCLLELQT
Sbjct: 781 EAHSSSPAGSPPSEPNCLLELQT 803


>gi|239743309 PREDICTED: similar to calcium-promoted Ras inactivator
           isoform 2 [Homo sapiens]
          Length = 731

 Score = 1356 bits (3510), Expect = 0.0
 Identities = 685/731 (93%), Positives = 685/731 (93%), Gaps = 46/731 (6%)

Query: 73  MDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEIHLRLEVWPGARA 132
           MDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEIHLRLEVWPGARA
Sbjct: 1   MDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEIHLRLEVWPGARA 60

Query: 133 CRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEGA 192
           CRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEGA
Sbjct: 61  CRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEGA 120

Query: 193 MEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGNLGSL 252
           MEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGNLGSL
Sbjct: 121 MEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGNLGSL 180

Query: 253 QLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVATNLLK 312
           QLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVATNLLK
Sbjct: 181 QLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVATNLLK 240

Query: 313 LFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSVESFLKVAGMQYLHGVLGPII 372
           LFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSVESFLKVAGMQYLHGVLGPII
Sbjct: 241 LFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSVESFLKVAGMQYLHGVLGPII 300

Query: 373 NKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSALSRSVR 432
           NKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSALSRSVR
Sbjct: 301 NKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSALSRSVR 360

Query: 433 ACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFHLRERHA 492
           ACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFHLRERHA
Sbjct: 361 ACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFHLRERHA 420

Query: 493 DARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVHQGVAQLKDFITKLVDIEEK 552
           DARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVHQGVAQLKDFITKLVDIEEK
Sbjct: 421 DARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVHQGVAQLKDFITKLVDIEEK 480

Query: 553 DELDLQRTLSLQAPPVKEGPLFIHRTKGKGPLMSSSFKKLYFSLTTEALSFAKTPSS--- 609
           DELDLQRTLSLQAPPVKEGPLFIHRTKGKGPLMSSSFKKLYFSLTTEALSFAKTPSS   
Sbjct: 481 DELDLQRTLSLQAPPVKEGPLFIHRTKGKGPLMSSSFKKLYFSLTTEALSFAKTPSSKKS 540

Query: 610 -------------------------------------------KCVNELNQWLSALRKVS 626
                                                      KCVNELNQWLSALRKVS
Sbjct: 541 ALIKLANIRAAEKVEEKSFGGSHVMQVIYTDDAGRPQTAYLQCKCVNELNQWLSALRKVS 600

Query: 627 INNTGLLGSYHPGVFRGDKWSCCHQKEKTGQGCDKTRSRVTLQEWNDPLDHDLEAQLIYR 686
           INNTGLLGSYHPGVFRGDKWSCCHQKEKTGQGCDKTRSRVTLQEWNDPLDHDLEAQLIYR
Sbjct: 601 INNTGLLGSYHPGVFRGDKWSCCHQKEKTGQGCDKTRSRVTLQEWNDPLDHDLEAQLIYR 660

Query: 687 HLLGVEAMLWERHRELSGGAEAGTVPTSPGKVPEDSLARLLRVLQDLREAHSSSPAGSPP 746
           HLLGVEAMLWERHRELSGGAEAGTVPTSPGKVPEDSLARLLRVLQDLREAHSSSPAGSPP
Sbjct: 661 HLLGVEAMLWERHRELSGGAEAGTVPTSPGKVPEDSLARLLRVLQDLREAHSSSPAGSPP 720

Query: 747 SEPNCLLELQT 757
           SEPNCLLELQT
Sbjct: 721 SEPNCLLELQT 731



 Score = 43.5 bits (101), Expect = 7e-04
 Identities = 27/89 (30%), Positives = 44/89 (49%), Gaps = 2/89 (2%)

Query: 2   AKRSSLYIRIVEGKNLPAKDITGSSDPYCIVKVDNEPIIRTATVWKTLCPFWGEEYQVHL 61
           A+   L   ++E ++L  KD  G+SDP+  V+        T+ V K+  P W E ++  L
Sbjct: 58  ARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGR-TRETSIVKKSCYPRWNETFEFEL 116

Query: 62  PP-TFHAVAFYVMDEDALSRDDVIGKVCL 89
                 A+     D D +SR+D +GKV +
Sbjct: 117 QEGAMEALCVEAWDWDLVSRNDFLGKVVI 145


>gi|239508992 PREDICTED: similar to calcium-promoted Ras inactivator
           isoform 1 [Homo sapiens]
          Length = 731

 Score = 1356 bits (3510), Expect = 0.0
 Identities = 685/731 (93%), Positives = 685/731 (93%), Gaps = 46/731 (6%)

Query: 73  MDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEIHLRLEVWPGARA 132
           MDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEIHLRLEVWPGARA
Sbjct: 1   MDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEIHLRLEVWPGARA 60

Query: 133 CRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEGA 192
           CRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEGA
Sbjct: 61  CRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEGA 120

Query: 193 MEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGNLGSL 252
           MEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGNLGSL
Sbjct: 121 MEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGNLGSL 180

Query: 253 QLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVATNLLK 312
           QLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVATNLLK
Sbjct: 181 QLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVATNLLK 240

Query: 313 LFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSVESFLKVAGMQYLHGVLGPII 372
           LFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSVESFLKVAGMQYLHGVLGPII
Sbjct: 241 LFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSVESFLKVAGMQYLHGVLGPII 300

Query: 373 NKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSALSRSVR 432
           NKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSALSRSVR
Sbjct: 301 NKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSALSRSVR 360

Query: 433 ACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFHLRERHA 492
           ACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFHLRERHA
Sbjct: 361 ACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFHLRERHA 420

Query: 493 DARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVHQGVAQLKDFITKLVDIEEK 552
           DARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVHQGVAQLKDFITKLVDIEEK
Sbjct: 421 DARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVHQGVAQLKDFITKLVDIEEK 480

Query: 553 DELDLQRTLSLQAPPVKEGPLFIHRTKGKGPLMSSSFKKLYFSLTTEALSFAKTPSS--- 609
           DELDLQRTLSLQAPPVKEGPLFIHRTKGKGPLMSSSFKKLYFSLTTEALSFAKTPSS   
Sbjct: 481 DELDLQRTLSLQAPPVKEGPLFIHRTKGKGPLMSSSFKKLYFSLTTEALSFAKTPSSKKS 540

Query: 610 -------------------------------------------KCVNELNQWLSALRKVS 626
                                                      KCVNELNQWLSALRKVS
Sbjct: 541 ALIKLANIRAAEKVEEKSFGGSHVMQVIYTDDAGRPQTAYLQCKCVNELNQWLSALRKVS 600

Query: 627 INNTGLLGSYHPGVFRGDKWSCCHQKEKTGQGCDKTRSRVTLQEWNDPLDHDLEAQLIYR 686
           INNTGLLGSYHPGVFRGDKWSCCHQKEKTGQGCDKTRSRVTLQEWNDPLDHDLEAQLIYR
Sbjct: 601 INNTGLLGSYHPGVFRGDKWSCCHQKEKTGQGCDKTRSRVTLQEWNDPLDHDLEAQLIYR 660

Query: 687 HLLGVEAMLWERHRELSGGAEAGTVPTSPGKVPEDSLARLLRVLQDLREAHSSSPAGSPP 746
           HLLGVEAMLWERHRELSGGAEAGTVPTSPGKVPEDSLARLLRVLQDLREAHSSSPAGSPP
Sbjct: 661 HLLGVEAMLWERHRELSGGAEAGTVPTSPGKVPEDSLARLLRVLQDLREAHSSSPAGSPP 720

Query: 747 SEPNCLLELQT 757
           SEPNCLLELQT
Sbjct: 721 SEPNCLLELQT 731



 Score = 43.5 bits (101), Expect = 7e-04
 Identities = 27/89 (30%), Positives = 44/89 (49%), Gaps = 2/89 (2%)

Query: 2   AKRSSLYIRIVEGKNLPAKDITGSSDPYCIVKVDNEPIIRTATVWKTLCPFWGEEYQVHL 61
           A+   L   ++E ++L  KD  G+SDP+  V+        T+ V K+  P W E ++  L
Sbjct: 58  ARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGR-TRETSIVKKSCYPRWNETFEFEL 116

Query: 62  PP-TFHAVAFYVMDEDALSRDDVIGKVCL 89
                 A+     D D +SR+D +GKV +
Sbjct: 117 QEGAMEALCVEAWDWDLVSRNDFLGKVVI 145


>gi|4759026 RAS protein activator like 1 [Homo sapiens]
          Length = 804

 Score =  674 bits (1738), Expect = 0.0
 Identities = 368/794 (46%), Positives = 495/794 (62%), Gaps = 65/794 (8%)

Query: 1   MAKRSSLYIRIVEGKNLPAKDITGSSDPYCIVKVDNEPIIRTATVWKTLCPFWGEEYQVH 60
           MAK SSL +R+VEG+ LPAKD++GSSDPYC+VKVD+E + RTATVW++L PFWGEEY VH
Sbjct: 1   MAKSSSLNVRVVEGRALPAKDVSGSSDPYCLVKVDDEVVARTATVWRSLGPFWGEEYTVH 60

Query: 61  LPPTFHAVAFYVMDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEI 120
           LP  FH +AFYV+DED +  DD+IGK+ L+R+ I + P+G   W +L+ VDPD EVQGEI
Sbjct: 61  LPLDFHQLAFYVLDEDTVGHDDIIGKISLSREAITADPRGIDSWINLSRVDPDAEVQGEI 120

Query: 121 HLRLEVWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRW 180
            L +++    +   LRC VL ARDLAP+D +GTSDPF RV +  ++ ETS +KK+ +P W
Sbjct: 121 CLSVQMLEDGQGRCLRCHVLHARDLAPRDISGTSDPFARVFWGSQSLETSTIKKTRFPHW 180

Query: 181 NETFEFELQEGAMEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSK 240
           +E  E     GA   L VE WDWD+V +NDFLG V    + L+  +  +GWFRL P   +
Sbjct: 181 DEVLELREMPGAPSPLRVELWDWDMVGKNDFLGMVEFSPKTLQ-QKPPKGWFRLLP-FPR 238

Query: 241 SRRHDEGNLGSLQLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQ-----LIPLIE 295
           +     GNLG+L+++VRL ++ VLPS  YQPL+ LL   V    QGP +      + L+E
Sbjct: 239 AEEDSGGNLGALRVKVRLIEDRVLPSQCYQPLMELLMESV----QGPAEEDTASPLALLE 294

Query: 296 ETTSTECRQDVATNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSVESF 355
           E T  +CRQD+AT L+KLFLG+GLA  FLD L + E++RT + NTLFRSNSLASKS+E F
Sbjct: 295 ELTLGDCRQDLATKLVKLFLGRGLAGHFLDYLTRREVARTMDPNTLFRSNSLASKSMEQF 354

Query: 356 LKVAGMQYLHGVLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQT 415
           +K+ GM YLH VL P+I++VFEEKKY+ELDP K+++            +E ++ E S   
Sbjct: 355 MKLVGMPYLHEVLKPVISRVFEEKKYMELDPCKMDLGRTRRISFKGALSEEQMRETSLGL 414

Query: 416 LRAHLGALLSALSRSVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFF 475
           L  +LG ++ A+  SV  CP  +R  F+QL RRV ERFP A+H++V ++A++ FL LRFF
Sbjct: 415 LTGYLGPIVDAIVGSVGRCPPAMRLAFKQLHRRVEERFPQAEHQDVKYLAISGFLFLRFF 474

Query: 476 SPAIMSPKLFHLRERHADARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVHQG 535
           +PAI++PKLF LR++HAD +TSR+LLLLAKAVQ++GN+     + KE WM PL P + Q 
Sbjct: 475 APAILTPKLFDLRDQHADPQTSRSLLLLAKAVQSIGNLGQQLGQGKELWMAPLHPFLLQC 534

Query: 536 VAQLKDFITKLVDIEEKDELDLQRTLSLQAPPVKEGPLFIHRTKGKGPLMSSSFKKLYFS 595
           V++++DF+ +LVD++  +     R L   +  V+EG L   + +  G     +FKK Y  
Sbjct: 535 VSRVRDFLDRLVDVDGDEAGVPARALFPPSAIVREGYLLKRKEEPAGLATRFAFKKRYVW 594

Query: 596 LTTEALSFAKTP----------------------------------------------SS 609
           L+ E LSF+K+P                                                
Sbjct: 595 LSGETLSFSKSPEWQMCHSIPVSHIRAVERVDEGAFQLPHVMQVVTQDGTGALHTTYLQC 654

Query: 610 KCVNELNQWLSALRKVSINNTGLLGSYHPGVFRGDKWSCCHQKEKTGQGCDKTRSRVTLQ 669
           K VNELNQWLSALRK S  N   L + HPG FR  +W+CC Q E++  GC +T S VTL 
Sbjct: 655 KNVNELNQWLSALRKASAPNPNKLAACHPGAFRSARWTCCLQAERSAAGCSRTHSAVTLG 714

Query: 670 EWNDPLDHDLEAQLIYRHLLGVEAMLWERHRELSGGAEAGTVPTSPGKVPE------DSL 723
           +W+DPLD D EAQ +YR LL     L  R + L       T+    G  PE       + 
Sbjct: 715 DWSDPLDPDAEAQTVYRQLLLGRDQL--RLKLLEDSNMDTTLEADTGACPEVLARQRAAT 772

Query: 724 ARLLRVLQDLREAH 737
           ARLL VL DL  AH
Sbjct: 773 ARLLEVLADLDRAH 786


>gi|38201692 RAS p21 protein activator 3 [Homo sapiens]
          Length = 834

 Score =  301 bits (772), Expect = 1e-81
 Identities = 222/754 (29%), Positives = 352/754 (46%), Gaps = 106/754 (14%)

Query: 6   SLYIRIVEGKNLPAKDITGSS---DPYCIVKVDNEPIIRTATVWKTLCPFWGEEYQVHLP 62
           S+ I+I E KNLP+    G S   D YC V +D E + RT  V K+LCPF+GE++   +P
Sbjct: 13  SVKIKIGEAKNLPS--YPGPSKMRDCYCTVNLDQEEVFRTKIVEKSLCPFYGEDFYCEIP 70

Query: 63  PTFHAVAFYVMDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEIHL 122
            +F  ++FY+ D D   RD +IGKV + ++ +  +    + W  L  VD D EVQG++HL
Sbjct: 71  RSFRHLSFYIFDRDVFRRDSIIGKVAIQKEDLQKYHNRDT-WFQLQHVDADSEVQGKVHL 129

Query: 123 RLEVWP-----GARACRLRCSVLEARDLAPKDRNGTSDPFVRVR----YKGRTRETSIVK 173
            L +       G    +L   ++E + L     NG  DP+  V     ++   ++T + +
Sbjct: 130 ELRLSEVITDTGVVCHKLATRIVECQGLPIV--NGQCDPYATVTLAGPFRSEAKKTKVKR 187

Query: 174 KSCYPRWNETFEFEL--------------QEGAMEALCVEAWDWD---LVSRNDFLGKVV 216
           K+  P+++E F FE+              +E  ++ L +    W+   L   ++FLG++ 
Sbjct: 188 KTNNPQFDEVFYFEVTRPCSYSKKSHFDFEEEDVDKLEIRVDLWNASNLKFGDEFLGELR 247

Query: 217 IDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGNLGSLQLEVRLRDETVLPSSYYQPLVHLL 276
           I ++ LR     E W+ LQP  + S+     +LGSL+L V   ++ V  S YY PL  LL
Sbjct: 248 IPLKVLRQSSSYEAWYFLQPRDNGSKSLKPDDLGSLRLNVVYTEDHVFSSDYYSPLRDLL 307

Query: 277 CHEVKLGMQGPGQLIPLIEETTSTECRQDVATNLLKLFLGQGLAKDFLDLLFQLELSRTS 336
                +          L E       +Q+ A  L++LFL  G    F+  +   E+ RT 
Sbjct: 308 LKSADVEPVSASAAHILGEVCRE---KQEAAVPLVRLFLHYGRVVPFISAIASAEVKRTQ 364

Query: 337 ETNTLFRSNSLASKSVESFLKVAGMQYLHGVLGPIINKVFEEKKYVELDPSKVEVKDVGC 396
           + NT+FR NSLASK ++  +K+AGM YLH  L P I ++ +  K  E+DP K++      
Sbjct: 365 DPNTIFRGNSLASKCIDETMKLAGMHYLHVTLKPAIEEICQSHKPCEIDPVKLK------ 418

Query: 397 SGLHRPQTEAEVLEQSAQTLRAHLGALLSALSRSVRACPAVVRATFRQLFRRVRERFPGA 456
                   + E LE + + LR ++  +  A++ S  +CP V+   F  L     +RF   
Sbjct: 419 --------DGENLENNMENLRQYVDRVFHAITESGVSCPTVMCDIFFSLREAAAKRF--Q 468

Query: 457 QHENVPFIAVTSFLCLRFFSPAIMSPKLFHLRERHADARTSRTLLLLAKAVQNVGNMDTP 516
              +V + AV+SF+ LRFF+PAI+SP LF L   H D +TSRTL L++K VQ +G++   
Sbjct: 469 DDPDVRYTAVSSFIFLRFFAPAILSPNLFQLTPHHTDPQTSRTLTLISKTVQTLGSLSKS 528

Query: 517 ASRA-KEAWMEPLQPTVHQG--VAQLKDFITKLVDIEEKDELDLQRTLSLQAPPVKEGPL 573
            S + KE++M       ++      +K+F+  +     +D   +++ + L     KEG  
Sbjct: 529 KSASFKESYMATFYEFFNEQKYADAVKNFLDLISSSGRRDPKSVEQPIVL-----KEG-F 582

Query: 574 FIHRTKGKGPLMSSSFKKLYFSLTTEALSFAKT--------------------------- 606
            I R +G+      +FKK +F LT    ++ K+                           
Sbjct: 583 MIKRAQGRKRFGMKNFKKRWFRLTNHEFTYHKSKGDQPLYSIPIENILAVEKLEEESFKM 642

Query: 607 ---------------PSSKCVNELNQWLSALRKVSINNTGLLGSYHPGVFRGDKWSCCHQ 651
                           ++ CV E   W+  L KVS  N   L  YHP  +    W CC  
Sbjct: 643 KNMFQVIQPERALYIQANNCV-EAKDWIDILTKVSQCNQKRLTVYHPSAYLSGHWLCCRA 701

Query: 652 KEKTGQGCDKTRSRVTLQEWNDPLDHDLEAQLIY 685
              +  GC      +      D +D D E + IY
Sbjct: 702 PSDSAPGCSPCTGGLPANIQLD-IDGDRETERIY 734


>gi|12545408 RAS p21 protein activator 2 [Homo sapiens]
          Length = 849

 Score =  300 bits (767), Expect = 4e-81
 Identities = 224/788 (28%), Positives = 367/788 (46%), Gaps = 104/788 (13%)

Query: 6   SLYIRIVEGKNL-PAKDITGSSDPYCIVKVDNEPIIRTATVWKTLCPFWGEEYQVHLPPT 64
           SL  +I E KNL P        D +C + +D E + RT  V K+L PF+ EE+   +P T
Sbjct: 39  SLRGKICEAKNLLPYLGPHKMRDCFCTINLDQEEVYRTQVVEKSLSPFFSEEFYFEIPRT 98

Query: 65  FHAVAFYVMDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEIHLRL 124
           F  ++FYV D++ L RD  IGKV + ++ + +H  G   W  L  VD + EVQG++HL L
Sbjct: 99  FQYLSFYVYDKNVLQRDLRIGKVAIKKEDLCNH-SGKETWFSLQPVDSNSEVQGKVHLEL 157

Query: 125 E----VWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTR----ETSIVKKSC 176
           +    +      C+     ++A    P     + DP+  V   G +R    +T + KK+ 
Sbjct: 158 KLNELITENGTVCQQLVVHIKACHGLPLINGQSCDPYATVSLVGPSRNDQKKTKVKKKTS 217

Query: 177 YPRWNETF--------------EFELQEGAMEAL--CVEAWDWDLVSRNDFLGKVVIDVQ 220
            P++NE F              +F+++E  +E L   ++ W+   + ++ FLG++ + V 
Sbjct: 218 NPQFNEIFYFEVTRSSSYTRKSQFQVEEEDIEKLEIRIDLWNNGNLVQDVFLGEIKVPVN 277

Query: 221 RLRVVQQEEGWFRLQPDQSKSRRHDEGNLGSLQLEVRLRDETVLPSSYYQPLVHLLCHEV 280
            LR     + W+ LQP  + ++     +LGSL+L +   ++ VLPS YY PL  LL    
Sbjct: 278 VLRTDSSHQAWYLLQPRDNGNKSSKTDDLGSLRLNICYTEDYVLPSEYYGPLKTLLLKSP 337

Query: 281 KLGMQGPGQLIPLIEETTSTECRQDVATNLLKLFLGQGLAKDFLDLLFQLELSRTSETNT 340
            +          L E       + D    L++L L       F   + +L+L  T + NT
Sbjct: 338 DVQPISASAAYILSEICRD---KNDAVLPLVRLLLHHDKLVPFATAVAELDLKDTQDANT 394

Query: 341 LFRSNSLASKSVESFLKVAGMQYLHGVLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLH 400
           +FR NSLA++ ++  +K+ G  YL   L PI++++ +  K  E+DP K++          
Sbjct: 395 IFRGNSLATRCLDEMMKIVGGHYLKVTLKPILDEICDSSKSCEIDPIKLK---------- 444

Query: 401 RPQTEAEVLEQSAQTLRAHLGALLSALSRSVRACPAVVRATFRQLFRRVRERFPGAQHEN 460
               E + +E + + LR ++  L + + +S  +CP V+   F  L +   +RFP   H  
Sbjct: 445 ----EGDNVENNKENLRYYVDKLFNTIVKSSMSCPTVMCDIFYSLRQMATQRFPNDPH-- 498

Query: 461 VPFIAVTSFLCLRFFSPAIMSPKLFHLRERHADARTSRTLLLLAKAVQNV---GNMDTPA 517
           V + AV+SF+ LRFF+ A++SP  FHLR  H DA+T RTL L++K +Q +   G++    
Sbjct: 499 VQYSAVSSFVFLRFFAVAVVSPHTFHLRPHHPDAQTIRTLTLISKTIQTLGSWGSLSKSK 558

Query: 518 SRAKEAWM-EPLQPTVHQG-VAQLKDFITKLVDIEEKDELDLQRTLSLQAPPVKEGPLFI 575
           S  KE +M E  +    +G +  +K F+ ++   E K+       + L     KEG ++ 
Sbjct: 559 SSFKETFMCEFFKMFQEEGYIIAVKKFLDEISSTETKESSGTSEPVHL-----KEGEMY- 612

Query: 576 HRTKGKGPLMSSSFKKLYFSLTTEALSFAKTP---------------------------- 607
            R +G+  +   +FKK +F LT+  L++ K P                            
Sbjct: 613 KRAQGRTRIGKKNFKKRWFCLTSRELTYHKQPGKDAIYTIPVKNILAVEKLEESSFNKKN 672

Query: 608 --------------SSKCVNELNQWLSALRKVSINNTGLLGSYHPGVFRGDKWSCCHQKE 653
                         ++ CV E N+W+  L +VS  N   L  YHP V+    W CC +  
Sbjct: 673 MFQVIHTEKPLYVQANNCV-EANEWIDVLCRVSRCNQNRLSFYHPSVYLNGNWLCCQETG 731

Query: 654 KTGQGCDKTRSRVTLQEWNDPLDHDLEAQLIYRHLLGVEAMLWERHRELSGGAEAGTVPT 713
           +   GC    + V      D +D D E + IY  L  +  +  ++  E  G      V  
Sbjct: 732 ENTLGCKPCTAGVPADIQID-IDEDRETERIY-SLFTLSLLKLQKMEEACGTI---AVYQ 786

Query: 714 SPGKVPED 721
            P K P+D
Sbjct: 787 GPQKEPDD 794


>gi|226958575 RAS protein activator like 2 isoform 2 [Homo sapiens]
          Length = 1280

 Score =  132 bits (333), Expect = 9e-31
 Identities = 117/407 (28%), Positives = 189/407 (46%), Gaps = 54/407 (13%)

Query: 121 HLRLEVWPGARACR-----LRCSVLEARDLAPKDRNGTS---DPFVRVRYKGRTRETSIV 172
           +LR  V P    CR     LR  ++EA+DLAPK +       D  +  R   +T+  +I 
Sbjct: 300 NLRRTVQPNKDNCRRAENVLRLWIIEAKDLAPKKKYFCELCLDDTLFARTTSKTKADNIF 359

Query: 173 KKSCYPRWNETFEFELQEGAMEALCVEAWDWDLVSR-----NDFLGKVVIDVQRLRVVQQ 227
                  W E FEF      + ++ V  +  D+  +     N+++G V I    +   Q 
Sbjct: 360 -------WGEHFEF-FSLPPLHSITVHIYK-DVEKKKKKDKNNYVGLVNIPTASVTGRQF 410

Query: 228 EEGWFRLQ-PDQSKSRRHDEGNLGSLQLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQG 286
            E W+ +  P  +K +        S++++ R +  T+LP   Y+     +     +    
Sbjct: 411 VEKWYPVSTPTPNKGKTGGP----SIRIKSRFQTITILPMEQYKEFAEFVTSNYTM---- 462

Query: 287 PGQLIPLIEETTSTECRQDVATNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTL-FRSN 345
              L  ++E   S   ++++A  L+ +    G AKDFL  L   E+ R  E + L FR N
Sbjct: 463 ---LCSVLEPVISVRNKEELACALVHILQSTGRAKDFLTDLVMSEVDRCGEHDVLIFREN 519

Query: 346 SLASKSVESFLKVAGMQYLHGVLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTE 405
           ++A+KS+E +LK+ G QYLH  LG  I  ++E  +  E+DPSK       CS        
Sbjct: 520 TIATKSIEEYLKLVGQQYLHDALGEFIKALYESDENCEVDPSK-------CSS------- 565

Query: 406 AEVLEQSAQTLRAHLGALLSALSRSVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIA 465
           +E+++  +  L+         +  S    P  ++  F    ++   R  G Q  +   I+
Sbjct: 566 SELIDHQSN-LKMCCELAFCKIINSYCVFPRELKEVFASWKQQCLNR--GKQDISERLIS 622

Query: 466 VTSFLCLRFFSPAIMSPKLFHLRERHADARTSRTLLLLAKAVQNVGN 512
            + FL  RF  PAIMSP LF+L + + D RTSRTL L+AK +QN+ N
Sbjct: 623 ASLFL--RFLCPAIMSPSLFNLMQEYPDDRTSRTLTLIAKVIQNLAN 667



 Score = 32.3 bits (72), Expect = 1.7
 Identities = 14/56 (25%), Positives = 27/56 (48%)

Query: 17  LPAKDITGSSDPYCIVKVDNEPIIRTATVWKTLCPFWGEEYQVHLPPTFHAVAFYV 72
           + AKD+      +C + +D+    RT +  K    FWGE ++    P  H++  ++
Sbjct: 324 IEAKDLAPKKKYFCELCLDDTLFARTTSKTKADNIFWGEHFEFFSLPPLHSITVHI 379


>gi|4758808 RAS protein activator like 2 isoform 1 [Homo sapiens]
          Length = 1139

 Score =  132 bits (333), Expect = 9e-31
 Identities = 117/407 (28%), Positives = 189/407 (46%), Gaps = 54/407 (13%)

Query: 121 HLRLEVWPGARACR-----LRCSVLEARDLAPKDRNGTS---DPFVRVRYKGRTRETSIV 172
           +LR  V P    CR     LR  ++EA+DLAPK +       D  +  R   +T+  +I 
Sbjct: 152 NLRRTVQPNKDNCRRAENVLRLWIIEAKDLAPKKKYFCELCLDDTLFARTTSKTKADNIF 211

Query: 173 KKSCYPRWNETFEFELQEGAMEALCVEAWDWDLVSR-----NDFLGKVVIDVQRLRVVQQ 227
                  W E FEF      + ++ V  +  D+  +     N+++G V I    +   Q 
Sbjct: 212 -------WGEHFEF-FSLPPLHSITVHIYK-DVEKKKKKDKNNYVGLVNIPTASVTGRQF 262

Query: 228 EEGWFRLQ-PDQSKSRRHDEGNLGSLQLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQG 286
            E W+ +  P  +K +        S++++ R +  T+LP   Y+     +     +    
Sbjct: 263 VEKWYPVSTPTPNKGKTGGP----SIRIKSRFQTITILPMEQYKEFAEFVTSNYTM---- 314

Query: 287 PGQLIPLIEETTSTECRQDVATNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTL-FRSN 345
              L  ++E   S   ++++A  L+ +    G AKDFL  L   E+ R  E + L FR N
Sbjct: 315 ---LCSVLEPVISVRNKEELACALVHILQSTGRAKDFLTDLVMSEVDRCGEHDVLIFREN 371

Query: 346 SLASKSVESFLKVAGMQYLHGVLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTE 405
           ++A+KS+E +LK+ G QYLH  LG  I  ++E  +  E+DPSK       CS        
Sbjct: 372 TIATKSIEEYLKLVGQQYLHDALGEFIKALYESDENCEVDPSK-------CSS------- 417

Query: 406 AEVLEQSAQTLRAHLGALLSALSRSVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIA 465
           +E+++  +  L+         +  S    P  ++  F    ++   R  G Q  +   I+
Sbjct: 418 SELIDHQSN-LKMCCELAFCKIINSYCVFPRELKEVFASWKQQCLNR--GKQDISERLIS 474

Query: 466 VTSFLCLRFFSPAIMSPKLFHLRERHADARTSRTLLLLAKAVQNVGN 512
            + FL  RF  PAIMSP LF+L + + D RTSRTL L+AK +QN+ N
Sbjct: 475 ASLFL--RFLCPAIMSPSLFNLMQEYPDDRTSRTLTLIAKVIQNLAN 519



 Score = 32.3 bits (72), Expect = 1.7
 Identities = 14/56 (25%), Positives = 27/56 (48%)

Query: 17  LPAKDITGSSDPYCIVKVDNEPIIRTATVWKTLCPFWGEEYQVHLPPTFHAVAFYV 72
           + AKD+      +C + +D+    RT +  K    FWGE ++    P  H++  ++
Sbjct: 176 IEAKDLAPKKKYFCELCLDDTLFARTTSKTKADNIFWGEHFEFFSLPPLHSITVHI 231


>gi|41281683 disabled homolog 2 interacting protein isoform 2 [Homo
           sapiens]
          Length = 1065

 Score =  118 bits (295), Expect = 2e-26
 Identities = 113/443 (25%), Positives = 192/443 (43%), Gaps = 54/443 (12%)

Query: 135 LRCSVLEARDLAPKDRNGTS---DPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEG 191
           L+  V+EA+DL  K +       D  +  R  G+ +  ++        W E FEF     
Sbjct: 91  LKLWVIEAKDLPAKKKYLCELCLDDVLYARTTGKLKTDNVF-------WGEHFEFHNLPP 143

Query: 192 AMEA---LCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGN 248
                  L  E        RN +LG V +    +   Q  E W+   P  + + +  +G 
Sbjct: 144 LRTVTVHLYRETDKKKKKERNSYLGLVSLPAASVAGRQFVEKWY---PVVTPNPKGGKGP 200

Query: 249 LGSLQLEVRLRDETVLPSSYYQPLV-HLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVA 307
              ++++ R +  T+LP   Y+    H+  H + L           +E   S + ++++A
Sbjct: 201 GPMIRIKARYQTITILPMEMYKEFAEHITNHYLGL--------CAALEPILSAKTKEEMA 252

Query: 308 TNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTL-FRSNSLASKSVESFLKVAGMQYLHG 366
           + L+ +    G  KDFL  L   E+ R  +   L FR N+LA+K++E +LK+ G +YL  
Sbjct: 253 SALVHILQSTGKVKDFLTDLMMSEVDRCGDNEHLIFRENTLATKAIEEYLKLVGQKYLQD 312

Query: 367 VLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSA 426
            LG  I  ++E  +  E+DPSK       CS    P+ +          L+         
Sbjct: 313 ALGEFIKALYESDENCEVDPSK-------CSAADLPEHQGN--------LKMCCELAFCK 357

Query: 427 LSRSVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFH 486
           +  S    P  ++    ++F   R+        ++    +++ L LRF  PAIMSP LF+
Sbjct: 358 IINSYCVFPRELK----EVFASWRQECSSRGRPDISERLISASLFLRFLCPAIMSPSLFN 413

Query: 487 LRERHADARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVHQGVAQLKDFITKL 546
           L + + D RT+RTL L+AK  QN+ N     S  KE +M  +   +      ++ F+ ++
Sbjct: 414 LLQEYPDDRTARTLTLIAKVTQNLANFAKFGS--KEEYMSFMNQFLEHEWTNMQRFLLEI 471

Query: 547 VDIEE-------KDELDLQRTLS 562
            + E        +  +DL R LS
Sbjct: 472 SNPETLSNTAGFEGYIDLGRELS 494



 Score = 34.7 bits (78), Expect = 0.34
 Identities = 26/93 (27%), Positives = 41/93 (44%), Gaps = 9/93 (9%)

Query: 7   LYIRIVEGKNLPAKDITGSSDPYCIVKVDNEPIIRTATVWKTLCPFWGEEYQVHLPPTFH 66
           L + ++E K+LPAK         C + +D+    RT    KT   FWGE ++ H  P   
Sbjct: 91  LKLWVIEAKDLPAK-----KKYLCELCLDDVLYARTTGKLKTDNVFWGEHFEFHNLPPLR 145

Query: 67  AVAFYVMDE----DALSRDDVIGKVCLTRDTIA 95
            V  ++  E        R+  +G V L   ++A
Sbjct: 146 TVTVHLYRETDKKKKKERNSYLGLVSLPAASVA 178


>gi|94967023 disabled homolog 2 interacting protein isoform 1 [Homo
           sapiens]
          Length = 1132

 Score =  118 bits (295), Expect = 2e-26
 Identities = 113/443 (25%), Positives = 192/443 (43%), Gaps = 54/443 (12%)

Query: 135 LRCSVLEARDLAPKDRNGTS---DPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEG 191
           L+  V+EA+DL  K +       D  +  R  G+ +  ++        W E FEF     
Sbjct: 187 LKLWVIEAKDLPAKKKYLCELCLDDVLYARTTGKLKTDNVF-------WGEHFEFHNLPP 239

Query: 192 AMEA---LCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGN 248
                  L  E        RN +LG V +    +   Q  E W+   P  + + +  +G 
Sbjct: 240 LRTVTVHLYRETDKKKKKERNSYLGLVSLPAASVAGRQFVEKWY---PVVTPNPKGGKGP 296

Query: 249 LGSLQLEVRLRDETVLPSSYYQPLV-HLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVA 307
              ++++ R +  T+LP   Y+    H+  H + L           +E   S + ++++A
Sbjct: 297 GPMIRIKARYQTITILPMEMYKEFAEHITNHYLGL--------CAALEPILSAKTKEEMA 348

Query: 308 TNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTL-FRSNSLASKSVESFLKVAGMQYLHG 366
           + L+ +    G  KDFL  L   E+ R  +   L FR N+LA+K++E +LK+ G +YL  
Sbjct: 349 SALVHILQSTGKVKDFLTDLMMSEVDRCGDNEHLIFRENTLATKAIEEYLKLVGQKYLQD 408

Query: 367 VLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSA 426
            LG  I  ++E  +  E+DPSK       CS    P+ +          L+         
Sbjct: 409 ALGEFIKALYESDENCEVDPSK-------CSAADLPEHQGN--------LKMCCELAFCK 453

Query: 427 LSRSVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFH 486
           +  S    P  ++    ++F   R+        ++    +++ L LRF  PAIMSP LF+
Sbjct: 454 IINSYCVFPRELK----EVFASWRQECSSRGRPDISERLISASLFLRFLCPAIMSPSLFN 509

Query: 487 LRERHADARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVHQGVAQLKDFITKL 546
           L + + D RT+RTL L+AK  QN+ N     S  KE +M  +   +      ++ F+ ++
Sbjct: 510 LLQEYPDDRTARTLTLIAKVTQNLANFAKFGS--KEEYMSFMNQFLEHEWTNMQRFLLEI 567

Query: 547 VDIEE-------KDELDLQRTLS 562
            + E        +  +DL R LS
Sbjct: 568 SNPETLSNTAGFEGYIDLGRELS 590



 Score = 34.7 bits (78), Expect = 0.34
 Identities = 26/93 (27%), Positives = 41/93 (44%), Gaps = 9/93 (9%)

Query: 7   LYIRIVEGKNLPAKDITGSSDPYCIVKVDNEPIIRTATVWKTLCPFWGEEYQVHLPPTFH 66
           L + ++E K+LPAK         C + +D+    RT    KT   FWGE ++ H  P   
Sbjct: 187 LKLWVIEAKDLPAK-----KKYLCELCLDDVLYARTTGKLKTDNVFWGEHFEFHNLPPLR 241

Query: 67  AVAFYVMDE----DALSRDDVIGKVCLTRDTIA 95
            V  ++  E        R+  +G V L   ++A
Sbjct: 242 TVTVHLYRETDKKKKKERNSYLGLVSLPAASVA 274


>gi|194248068 synaptic Ras GTPase activating protein 1 [Homo
           sapiens]
          Length = 1343

 Score =  115 bits (289), Expect = 1e-25
 Identities = 107/410 (26%), Positives = 179/410 (43%), Gaps = 56/410 (13%)

Query: 135 LRCSVLEARDLAPKDRNGTS---DPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEG 191
           L+  ++EAR+L PK R       D  +  R   + R  S         W E FEF     
Sbjct: 264 LKLWIIEARELPPKKRYYCELCLDDMLYARTTSKPRSAS----GDTVFWGEHFEFN-NLP 318

Query: 192 AMEALCVEAW-DWDLVSRND---FLGKVVIDVQRLRVVQQEEGWFRLQPDQSK------- 240
           A+ AL +  + D D   + D   ++G V + V  L      E W+ +             
Sbjct: 319 AVRALRLHLYRDSDKKRKKDKAGYVGLVTVPVATLAGRHFTEQWYPVTLPTGSGGSGGMG 378

Query: 241 ----------SRRHDEGNLGSLQLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQL 290
                     S    +G   +++L+ R +  ++LP   Y+     + +  ++       L
Sbjct: 379 SGGGGGSGGGSGGKGKGGCPAVRLKARYQTMSILPMELYKEFAEYVTNHYRM-------L 431

Query: 291 IPLIEETTSTECRQDVATNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTL-FRSNSLAS 349
             ++E   + + +++VA+ L+ +    G AKDFL  +   E+ R  E   L FR N+LA+
Sbjct: 432 CAVLEPALNVKGKEEVASALVHILQSTGKAKDFLSDMAMSEVDRFMEREHLIFRENTLAT 491

Query: 350 KSVESFLKVAGMQYLHGVLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVL 409
           K++E ++++ G +YL   +G  I  ++E ++  E+DP K       C+        A  L
Sbjct: 492 KAIEEYMRLIGQKYLKDAIGEFIRALYESEENCEVDPIK-------CT--------ASSL 536

Query: 410 EQSAQTLRAHLGALLSALSRSVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSF 469
            +    LR      L  +  S    P  ++  F     R  ER      E++    +++ 
Sbjct: 537 AEHQANLRMCCELALCKVVNSHCVFPRELKEVFASWRLRCAER----GREDIADRLISAS 592

Query: 470 LCLRFFSPAIMSPKLFHLRERHADARTSRTLLLLAKAVQNVGNMDTPASR 519
           L LRF  PAIMSP LF L + + D +TSRTL L+AK +QN+ N     S+
Sbjct: 593 LFLRFLCPAIMSPSLFGLMQEYPDEQTSRTLTLIAKVIQNLANFSKFTSK 642


>gi|4506431 RAS p21 protein activator 1 isoform 1 [Homo sapiens]
          Length = 1047

 Score =  105 bits (263), Expect = 1e-22
 Identities = 89/326 (27%), Positives = 148/326 (45%), Gaps = 46/326 (14%)

Query: 250 GSLQLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQD---V 306
           GSL++  R   E ++P   Y     L+  +              +    S  C QD   +
Sbjct: 704 GSLRVRARYSMEKIMPEEEYSEFKELILQKELH-----------VVYALSHVCGQDRTLL 752

Query: 307 ATNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSVESFLKVAGMQYLHG 366
           A+ LL++FL + L    L  L   E+S   E  TLFR+ +LAS  +E ++K    Q++H 
Sbjct: 753 ASILLRIFLHEKLESLLLCTLNDREISMEDEATTLFRATTLASTLMEQYMKATATQFVHH 812

Query: 367 VLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSA 426
            L   I K+ E K+  EL PSK+E                    +   T   HL  +LS 
Sbjct: 813 ALKDSILKIMESKQSCELSPSKLE------------------KNEDVNTNLTHLLNILSE 854

Query: 427 LSRSVRACPAVVRATFRQLF----RRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSP 482
           L   +     ++  T R ++    + V+ ++P   +  +    V+ F+ LR   PAI++P
Sbjct: 855 LVEKIFMASEILPPTLRYIYGCLQKSVQHKWP--TNTTMRTRVVSGFVFLRLICPAILNP 912

Query: 483 KLFHLRERHADARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTV----HQGVAQ 538
           ++F++         +RTL+L+AK+VQN+ N+      AKE +ME + P +    H+ +  
Sbjct: 913 RMFNIISDSPSPIAARTLILVAKSVQNLANL--VEFGAKEPYMEGVNPFIKSNKHRMIMF 970

Query: 539 LKDF--ITKLVDIEEKDELDLQRTLS 562
           L +   + +L D  E    DL R L+
Sbjct: 971 LDELGNVPELPDTTEHSRTDLSRDLA 996


>gi|12545406 RAS p21 protein activator 1 isoform 2 [Homo sapiens]
          Length = 870

 Score =  105 bits (263), Expect = 1e-22
 Identities = 89/326 (27%), Positives = 148/326 (45%), Gaps = 46/326 (14%)

Query: 250 GSLQLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQD---V 306
           GSL++  R   E ++P   Y     L+  +              +    S  C QD   +
Sbjct: 527 GSLRVRARYSMEKIMPEEEYSEFKELILQKELH-----------VVYALSHVCGQDRTLL 575

Query: 307 ATNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSVESFLKVAGMQYLHG 366
           A+ LL++FL + L    L  L   E+S   E  TLFR+ +LAS  +E ++K    Q++H 
Sbjct: 576 ASILLRIFLHEKLESLLLCTLNDREISMEDEATTLFRATTLASTLMEQYMKATATQFVHH 635

Query: 367 VLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSA 426
            L   I K+ E K+  EL PSK+E                    +   T   HL  +LS 
Sbjct: 636 ALKDSILKIMESKQSCELSPSKLE------------------KNEDVNTNLTHLLNILSE 677

Query: 427 LSRSVRACPAVVRATFRQLF----RRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSP 482
           L   +     ++  T R ++    + V+ ++P   +  +    V+ F+ LR   PAI++P
Sbjct: 678 LVEKIFMASEILPPTLRYIYGCLQKSVQHKWP--TNTTMRTRVVSGFVFLRLICPAILNP 735

Query: 483 KLFHLRERHADARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTV----HQGVAQ 538
           ++F++         +RTL+L+AK+VQN+ N+      AKE +ME + P +    H+ +  
Sbjct: 736 RMFNIISDSPSPIAARTLILVAKSVQNLANL--VEFGAKEPYMEGVNPFIKSNKHRMIMF 793

Query: 539 LKDF--ITKLVDIEEKDELDLQRTLS 562
           L +   + +L D  E    DL R L+
Sbjct: 794 LDELGNVPELPDTTEHSRTDLSRDLA 819


>gi|38570146 synaptotagmin VII [Homo sapiens]
          Length = 403

 Score = 90.1 bits (222), Expect = 7e-18
 Identities = 67/229 (29%), Positives = 118/229 (51%), Gaps = 18/229 (7%)

Query: 3   KRSSLYIRIVEGKNLPAKDITGSSDPYCIVKV--DNEPIIRTATVWKTLCPFWGEEYQVH 60
           + S+L ++I++ + LPAKD +G+SDP+  + +  D +  + T    K L P W E +   
Sbjct: 148 QESTLTVKIMKAQELPAKDFSGTSDPFVKIYLLPDKKHKLETKVKRKNLNPHWNETFLFE 207

Query: 61  LPPTFHAVA----FYVMDEDALSRDDVIGKVCLTRDTI-ASHPKGFSGWAHLTEVDPDEE 115
             P    V       V+D D  SR+D IG+V +  + +  +  + F  W  L        
Sbjct: 208 GFPYEKVVQRILYLQVLDYDRFSRNDPIGEVSIPLNKVDLTQMQTF--WKDLKPCSDGSG 265

Query: 116 VQGEIHLRLEVWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRV--RYKGR---TRETS 170
            +GE+ L L   P A +  +  ++++AR+L   D  GTSDP+V+V   YK +    ++T 
Sbjct: 266 SRGELLLSLCYNPSANS--IIVNIIKARNLKAMDIGGTSDPYVKVWLMYKDKRVEKKKTV 323

Query: 171 IVKKSCYPRWNETFEFELQEGAME--ALCVEAWDWDLVSRNDFLGKVVI 217
            +K++  P +NE+F F++    +    + +   D D +SRND +GK+ +
Sbjct: 324 TMKRNLNPIFNESFAFDIPTEKLRETTIIITVMDKDKLSRNDVIGKIYL 372



 Score = 70.5 bits (171), Expect = 6e-12
 Identities = 42/116 (36%), Positives = 66/116 (56%), Gaps = 8/116 (6%)

Query: 135 LRCSVLEARDLAPKDRNGTSDPFVRVRY---KGRTRETSIVKKSCYPRWNETFEFE---L 188
           L   +++A++L  KD +GTSDPFV++     K    ET + +K+  P WNETF FE    
Sbjct: 152 LTVKIMKAQELPAKDFSGTSDPFVKIYLLPDKKHKLETKVKRKNLNPHWNETFLFEGFPY 211

Query: 189 QEGAMEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQP--DQSKSR 242
           ++     L ++  D+D  SRND +G+V I + ++ + Q +  W  L+P  D S SR
Sbjct: 212 EKVVQRILYLQVLDYDRFSRNDPIGEVSIPLNKVDLTQMQTFWKDLKPCSDGSGSR 267



 Score = 53.5 bits (127), Expect = 7e-07
 Identities = 33/96 (34%), Positives = 54/96 (56%), Gaps = 13/96 (13%)

Query: 5   SSLYIRIVEGKNLPAKDITGSSDPYCIV-------KVDNEPIIRTATVWKTLCPFWGEEY 57
           +S+ + I++ +NL A DI G+SDPY  V       +V+ +   +T T+ + L P + E +
Sbjct: 281 NSIIVNIIKARNLKAMDIGGTSDPYVKVWLMYKDKRVEKK---KTVTMKRNLNPIFNESF 337

Query: 58  QVHLPPTF---HAVAFYVMDEDALSRDDVIGKVCLT 90
              +P        +   VMD+D LSR+DVIGK+ L+
Sbjct: 338 AFDIPTEKLRETTIIITVMDKDKLSRNDVIGKIYLS 373


>gi|238550198 synaptotagmin III [Homo sapiens]
          Length = 590

 Score = 89.7 bits (221), Expect = 9e-18
 Identities = 70/220 (31%), Positives = 110/220 (50%), Gaps = 15/220 (6%)

Query: 7   LYIRIVEGKNLPAKDITGSSDPYCIVKV--DNEPIIRTATVWKTLCPFWGEEYQVHLPPT 64
           L +RI++  +LPAKD  G SDPY  + +  D +   +T    KTL P + E +Q  +P  
Sbjct: 316 LVVRILQALDLPAKDSNGFSDPYVKIYLLPDRKKKFQTKVHRKTLNPVFNETFQFSVPLA 375

Query: 65  FHA---VAFYVMDEDALSRDDVIGKVCLTR-DTIASHPKGFSGWAHLTEVDPDEEVQGEI 120
             A   + F V D D  SR D+IG+V L     +A  P     W  + E   ++   GE+
Sbjct: 376 ELAQRKLHFSVYDFDRFSRHDLIGQVVLDNLLELAEQPPDRPLWRDIVEGGSEKADLGEL 435

Query: 121 HLRLEVWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRY--KGR---TRETSIVKKS 175
           +  L   P   A RL  ++++A +L   D  G SDP+V+     +GR    R+TSI K +
Sbjct: 436 NFSLCYLP--TAGRLTVTIIKASNLKAMDLTGFSDPYVKASLISEGRRLKKRKTSIKKNT 493

Query: 176 CYPRWNETFEFELQEGAME--ALCVEAWDWDLVSRNDFLG 213
             P +NE   F++   ++E   L +   D+D +  N+ +G
Sbjct: 494 LNPTYNEALVFDVAPESVENVGLSIAVVDYDCIGHNEVIG 533



 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 33/85 (38%), Positives = 52/85 (61%), Gaps = 5/85 (5%)

Query: 139 VLEARDLAPKDRNGTSDPFVRVRY---KGRTRETSIVKKSCYPRWNETFEFE--LQEGAM 193
           +L+A DL  KD NG SDP+V++     + +  +T + +K+  P +NETF+F   L E A 
Sbjct: 320 ILQALDLPAKDSNGFSDPYVKIYLLPDRKKKFQTKVHRKTLNPVFNETFQFSVPLAELAQ 379

Query: 194 EALCVEAWDWDLVSRNDFLGKVVID 218
             L    +D+D  SR+D +G+VV+D
Sbjct: 380 RKLHFSVYDFDRFSRHDLIGQVVLD 404


>gi|238550196 synaptotagmin III [Homo sapiens]
          Length = 590

 Score = 89.7 bits (221), Expect = 9e-18
 Identities = 70/220 (31%), Positives = 110/220 (50%), Gaps = 15/220 (6%)

Query: 7   LYIRIVEGKNLPAKDITGSSDPYCIVKV--DNEPIIRTATVWKTLCPFWGEEYQVHLPPT 64
           L +RI++  +LPAKD  G SDPY  + +  D +   +T    KTL P + E +Q  +P  
Sbjct: 316 LVVRILQALDLPAKDSNGFSDPYVKIYLLPDRKKKFQTKVHRKTLNPVFNETFQFSVPLA 375

Query: 65  FHA---VAFYVMDEDALSRDDVIGKVCLTR-DTIASHPKGFSGWAHLTEVDPDEEVQGEI 120
             A   + F V D D  SR D+IG+V L     +A  P     W  + E   ++   GE+
Sbjct: 376 ELAQRKLHFSVYDFDRFSRHDLIGQVVLDNLLELAEQPPDRPLWRDIVEGGSEKADLGEL 435

Query: 121 HLRLEVWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRY--KGR---TRETSIVKKS 175
           +  L   P   A RL  ++++A +L   D  G SDP+V+     +GR    R+TSI K +
Sbjct: 436 NFSLCYLP--TAGRLTVTIIKASNLKAMDLTGFSDPYVKASLISEGRRLKKRKTSIKKNT 493

Query: 176 CYPRWNETFEFELQEGAME--ALCVEAWDWDLVSRNDFLG 213
             P +NE   F++   ++E   L +   D+D +  N+ +G
Sbjct: 494 LNPTYNEALVFDVAPESVENVGLSIAVVDYDCIGHNEVIG 533



 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 33/85 (38%), Positives = 52/85 (61%), Gaps = 5/85 (5%)

Query: 139 VLEARDLAPKDRNGTSDPFVRVRY---KGRTRETSIVKKSCYPRWNETFEFE--LQEGAM 193
           +L+A DL  KD NG SDP+V++     + +  +T + +K+  P +NETF+F   L E A 
Sbjct: 320 ILQALDLPAKDSNGFSDPYVKIYLLPDRKKKFQTKVHRKTLNPVFNETFQFSVPLAELAQ 379

Query: 194 EALCVEAWDWDLVSRNDFLGKVVID 218
             L    +D+D  SR+D +G+VV+D
Sbjct: 380 RKLHFSVYDFDRFSRHDLIGQVVLD 404


>gi|14150054 synaptotagmin III [Homo sapiens]
          Length = 590

 Score = 89.7 bits (221), Expect = 9e-18
 Identities = 70/220 (31%), Positives = 110/220 (50%), Gaps = 15/220 (6%)

Query: 7   LYIRIVEGKNLPAKDITGSSDPYCIVKV--DNEPIIRTATVWKTLCPFWGEEYQVHLPPT 64
           L +RI++  +LPAKD  G SDPY  + +  D +   +T    KTL P + E +Q  +P  
Sbjct: 316 LVVRILQALDLPAKDSNGFSDPYVKIYLLPDRKKKFQTKVHRKTLNPVFNETFQFSVPLA 375

Query: 65  FHA---VAFYVMDEDALSRDDVIGKVCLTR-DTIASHPKGFSGWAHLTEVDPDEEVQGEI 120
             A   + F V D D  SR D+IG+V L     +A  P     W  + E   ++   GE+
Sbjct: 376 ELAQRKLHFSVYDFDRFSRHDLIGQVVLDNLLELAEQPPDRPLWRDIVEGGSEKADLGEL 435

Query: 121 HLRLEVWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRY--KGR---TRETSIVKKS 175
           +  L   P   A RL  ++++A +L   D  G SDP+V+     +GR    R+TSI K +
Sbjct: 436 NFSLCYLP--TAGRLTVTIIKASNLKAMDLTGFSDPYVKASLISEGRRLKKRKTSIKKNT 493

Query: 176 CYPRWNETFEFELQEGAME--ALCVEAWDWDLVSRNDFLG 213
             P +NE   F++   ++E   L +   D+D +  N+ +G
Sbjct: 494 LNPTYNEALVFDVAPESVENVGLSIAVVDYDCIGHNEVIG 533



 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 33/85 (38%), Positives = 52/85 (61%), Gaps = 5/85 (5%)

Query: 139 VLEARDLAPKDRNGTSDPFVRVRY---KGRTRETSIVKKSCYPRWNETFEFE--LQEGAM 193
           +L+A DL  KD NG SDP+V++     + +  +T + +K+  P +NETF+F   L E A 
Sbjct: 320 ILQALDLPAKDSNGFSDPYVKIYLLPDRKKKFQTKVHRKTLNPVFNETFQFSVPLAELAQ 379

Query: 194 EALCVEAWDWDLVSRNDFLGKVVID 218
             L    +D+D  SR+D +G+VV+D
Sbjct: 380 RKLHFSVYDFDRFSRHDLIGQVVLD 404


>gi|130502162 RAS protein activator like 3 [Homo sapiens]
          Length = 1011

 Score = 87.0 bits (214), Expect = 6e-17
 Identities = 76/303 (25%), Positives = 135/303 (44%), Gaps = 31/303 (10%)

Query: 251 SLQLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVATNL 310
           +L+  +R R   VLPS  Y+ L   L            +L   +E     + ++++A  +
Sbjct: 414 ALRARIRARRLRVLPSERYKELAEFLTFHY-------ARLCGALEPALPAQAKEELAAAM 466

Query: 311 LKLFLGQGLAKDFLDLLFQLELSRTSETNTL-FRSNSLASKSVESFLKVAGMQYLHGVLG 369
           +++    G A+  +  L   EL+R      L FR N+LA+K+++ ++K+    YL   LG
Sbjct: 467 VRVLRATGRAQALVTDLGTAELARCGGREALLFRENTLATKAIDEYMKLVAQDYLQETLG 526

Query: 370 PIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSALSR 429
            ++ ++    +  E+DPSK       C     P+ +A         LR     +   +  
Sbjct: 527 QVVRRLCASTEDCEVDPSK-------CPASELPEHQAR--------LRNSCEEVFETIIH 571

Query: 430 SVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFHLRE 489
           S    PA +   F       +ER  G++      +  + F  LR   PAI++P LF L  
Sbjct: 572 SYDWFPAELGIVFSSWREACKER--GSEVLGPRLVCASLF--LRLLCPAILAPSLFGLAP 627

Query: 490 RHADARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVHQGVAQLKDFITK--LV 547
            H     +RTL L+AK +QN+ N   P    KEA+M  +   + +    ++ F+ +  +V
Sbjct: 628 DHPAPGPARTLTLIAKVIQNLANR-APFGE-KEAYMGFMNSFLEEHGPAMQCFLDQVAMV 685

Query: 548 DIE 550
           D++
Sbjct: 686 DVD 688


>gi|209447073 synaptotagmin I [Homo sapiens]
          Length = 422

 Score = 85.5 bits (210), Expect = 2e-16
 Identities = 67/230 (29%), Positives = 114/230 (49%), Gaps = 20/230 (8%)

Query: 3   KRSSLYIRIVEGKNLPAKDITGSSDPYCIVKV----DNEPIIRTATVWKTLCPFWGEEYQ 58
           + + L + I++   LPA D+ G+SDPY  VKV    D +    T    KTL P + E++ 
Sbjct: 155 QNNQLLVGIIQAAELPALDMGGTSDPY--VKVFLLPDKKKKFETKVHRKTLNPVFNEQFT 212

Query: 59  VHLPPT---FHAVAFYVMDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDE- 114
             +P +      +   V D D  S+ D+IG+  +  +T+         W  L   + +E 
Sbjct: 213 FKVPYSELGGKTLVMAVYDFDRFSKHDIIGEFKVPMNTV-DFGHVTEEWRDLQSAEKEEQ 271

Query: 115 EVQGEIHLRLEVWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRY-----KGRTRET 169
           E  G+I   L   P   A +L   +LEA++L   D  G SDP+V++       + + ++T
Sbjct: 272 EKLGDICFSLRYVP--TAGKLTVVILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKKKKT 329

Query: 170 SIVKKSCYPRWNETFEFEL--QEGAMEALCVEAWDWDLVSRNDFLGKVVI 217
           +I K +  P +NE+F FE+  ++     + V   D+D + +ND +GKV +
Sbjct: 330 TIKKNTLNPYYNESFSFEVPFEQIQKVQVVVTVLDYDKIGKNDAIGKVFV 379



 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 38/154 (24%), Positives = 75/154 (48%), Gaps = 11/154 (7%)

Query: 109 EVDPDEEVQGEIHLRLEVWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRY---KGR 165
           E   +EE  G++   L+     +  +L   +++A +L   D  GTSDP+V+V     K +
Sbjct: 135 EEPKEEEKLGKLQYSLDY--DFQNNQLLVGIIQAAELPALDMGGTSDPYVKVFLLPDKKK 192

Query: 166 TRETSIVKKSCYPRWNETFEFELQEGAM--EALCVEAWDWDLVSRNDFLGKVVIDVQRLR 223
             ET + +K+  P +NE F F++    +  + L +  +D+D  S++D +G+  + +  + 
Sbjct: 193 KFETKVHRKTLNPVFNEQFTFKVPYSELGGKTLVMAVYDFDRFSKHDIIGEFKVPMNTVD 252

Query: 224 VVQQEEGWFRLQPDQSKSRRHDEGNLGSLQLEVR 257
                E W  LQ     + + ++  LG +   +R
Sbjct: 253 FGHVTEEWRDLQ----SAEKEEQEKLGDICFSLR 282


>gi|5032139 synaptotagmin I [Homo sapiens]
          Length = 422

 Score = 85.5 bits (210), Expect = 2e-16
 Identities = 67/230 (29%), Positives = 114/230 (49%), Gaps = 20/230 (8%)

Query: 3   KRSSLYIRIVEGKNLPAKDITGSSDPYCIVKV----DNEPIIRTATVWKTLCPFWGEEYQ 58
           + + L + I++   LPA D+ G+SDPY  VKV    D +    T    KTL P + E++ 
Sbjct: 155 QNNQLLVGIIQAAELPALDMGGTSDPY--VKVFLLPDKKKKFETKVHRKTLNPVFNEQFT 212

Query: 59  VHLPPT---FHAVAFYVMDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDE- 114
             +P +      +   V D D  S+ D+IG+  +  +T+         W  L   + +E 
Sbjct: 213 FKVPYSELGGKTLVMAVYDFDRFSKHDIIGEFKVPMNTV-DFGHVTEEWRDLQSAEKEEQ 271

Query: 115 EVQGEIHLRLEVWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRY-----KGRTRET 169
           E  G+I   L   P   A +L   +LEA++L   D  G SDP+V++       + + ++T
Sbjct: 272 EKLGDICFSLRYVP--TAGKLTVVILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKKKKT 329

Query: 170 SIVKKSCYPRWNETFEFEL--QEGAMEALCVEAWDWDLVSRNDFLGKVVI 217
           +I K +  P +NE+F FE+  ++     + V   D+D + +ND +GKV +
Sbjct: 330 TIKKNTLNPYYNESFSFEVPFEQIQKVQVVVTVLDYDKIGKNDAIGKVFV 379



 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 38/154 (24%), Positives = 75/154 (48%), Gaps = 11/154 (7%)

Query: 109 EVDPDEEVQGEIHLRLEVWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRY---KGR 165
           E   +EE  G++   L+     +  +L   +++A +L   D  GTSDP+V+V     K +
Sbjct: 135 EEPKEEEKLGKLQYSLDY--DFQNNQLLVGIIQAAELPALDMGGTSDPYVKVFLLPDKKK 192

Query: 166 TRETSIVKKSCYPRWNETFEFELQEGAM--EALCVEAWDWDLVSRNDFLGKVVIDVQRLR 223
             ET + +K+  P +NE F F++    +  + L +  +D+D  S++D +G+  + +  + 
Sbjct: 193 KFETKVHRKTLNPVFNEQFTFKVPYSELGGKTLVMAVYDFDRFSKHDIIGEFKVPMNTVD 252

Query: 224 VVQQEEGWFRLQPDQSKSRRHDEGNLGSLQLEVR 257
                E W  LQ     + + ++  LG +   +R
Sbjct: 253 FGHVTEEWRDLQ----SAEKEEQEKLGDICFSLR 282


>gi|209447070 synaptotagmin I [Homo sapiens]
          Length = 422

 Score = 85.5 bits (210), Expect = 2e-16
 Identities = 67/230 (29%), Positives = 114/230 (49%), Gaps = 20/230 (8%)

Query: 3   KRSSLYIRIVEGKNLPAKDITGSSDPYCIVKV----DNEPIIRTATVWKTLCPFWGEEYQ 58
           + + L + I++   LPA D+ G+SDPY  VKV    D +    T    KTL P + E++ 
Sbjct: 155 QNNQLLVGIIQAAELPALDMGGTSDPY--VKVFLLPDKKKKFETKVHRKTLNPVFNEQFT 212

Query: 59  VHLPPT---FHAVAFYVMDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDE- 114
             +P +      +   V D D  S+ D+IG+  +  +T+         W  L   + +E 
Sbjct: 213 FKVPYSELGGKTLVMAVYDFDRFSKHDIIGEFKVPMNTV-DFGHVTEEWRDLQSAEKEEQ 271

Query: 115 EVQGEIHLRLEVWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRY-----KGRTRET 169
           E  G+I   L   P   A +L   +LEA++L   D  G SDP+V++       + + ++T
Sbjct: 272 EKLGDICFSLRYVP--TAGKLTVVILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKKKKT 329

Query: 170 SIVKKSCYPRWNETFEFEL--QEGAMEALCVEAWDWDLVSRNDFLGKVVI 217
           +I K +  P +NE+F FE+  ++     + V   D+D + +ND +GKV +
Sbjct: 330 TIKKNTLNPYYNESFSFEVPFEQIQKVQVVVTVLDYDKIGKNDAIGKVFV 379



 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 38/154 (24%), Positives = 75/154 (48%), Gaps = 11/154 (7%)

Query: 109 EVDPDEEVQGEIHLRLEVWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRY---KGR 165
           E   +EE  G++   L+     +  +L   +++A +L   D  GTSDP+V+V     K +
Sbjct: 135 EEPKEEEKLGKLQYSLDY--DFQNNQLLVGIIQAAELPALDMGGTSDPYVKVFLLPDKKK 192

Query: 166 TRETSIVKKSCYPRWNETFEFELQEGAM--EALCVEAWDWDLVSRNDFLGKVVIDVQRLR 223
             ET + +K+  P +NE F F++    +  + L +  +D+D  S++D +G+  + +  + 
Sbjct: 193 KFETKVHRKTLNPVFNEQFTFKVPYSELGGKTLVMAVYDFDRFSKHDIIGEFKVPMNTVD 252

Query: 224 VVQQEEGWFRLQPDQSKSRRHDEGNLGSLQLEVR 257
                E W  LQ     + + ++  LG +   +R
Sbjct: 253 FGHVTEEWRDLQ----SAEKEEQEKLGDICFSLR 282


>gi|45504376 synaptotagmin VI [Homo sapiens]
          Length = 425

 Score = 85.1 bits (209), Expect = 2e-16
 Identities = 70/223 (31%), Positives = 110/223 (49%), Gaps = 19/223 (8%)

Query: 6   SLYIRIVEGKNLPAKDITGSSDPYCIVKV--DNEPIIRTATVWKTLCPFWGEEYQVHLPP 63
           +L +RI++  +LPAKD  GSSDPY  + +  D +  ++T    KTL P + E +  H P 
Sbjct: 160 TLIVRILKAFDLPAKDFCGSSDPYVKIYLLPDRKCKLQTRVHRKTLNPTFDENF--HFPV 217

Query: 64  TFHAVA-----FYVMDEDALSRDDVIGKVCLTRDTIASH-PKGFSGWAHLTEVDPDEEVQ 117
            +  +A       V D D  SR D+IG+V L     AS   +  S W  +     +    
Sbjct: 218 PYEELADRKLHLSVFDFDRFSRHDMIGEVILDNLFEASDLSRETSIWKDIQYATSESVDL 277

Query: 118 GEIHLRLEVWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRY-----KGRTRETSIV 172
           GEI   L   P   A RL  +V++ R+L   D  G SDP+V+V       + + ++T+I 
Sbjct: 278 GEIMFSLCYLP--TAGRLTLTVIKCRNLKAMDITGYSDPYVKVSLLCDGRRLKKKKTTIK 335

Query: 173 KKSCYPRWNETFEFELQEGAME--ALCVEAWDWDLVSRNDFLG 213
           K +  P +NE   F++    M+  +L +   D+D V  N+ +G
Sbjct: 336 KNTLNPVYNEAIIFDIPPENMDQVSLLISVMDYDRVGHNEIIG 378



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 28/85 (32%), Positives = 51/85 (60%), Gaps = 5/85 (5%)

Query: 139 VLEARDLAPKDRNGTSDPFVRVRYKGRTR---ETSIVKKSCYPRWNETFEFEL--QEGAM 193
           +L+A DL  KD  G+SDP+V++      +   +T + +K+  P ++E F F +  +E A 
Sbjct: 165 ILKAFDLPAKDFCGSSDPYVKIYLLPDRKCKLQTRVHRKTLNPTFDENFHFPVPYEELAD 224

Query: 194 EALCVEAWDWDLVSRNDFLGKVVID 218
             L +  +D+D  SR+D +G+V++D
Sbjct: 225 RKLHLSVFDFDRFSRHDMIGEVILD 249


>gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens]
          Length = 671

 Score = 84.0 bits (206), Expect = 5e-16
 Identities = 43/102 (42%), Positives = 63/102 (61%), Gaps = 7/102 (6%)

Query: 139 VLEARDLAPKDRNGTSDPFVRVRY----KGRTRE-TSIVKKSCYPRWNETFEFELQEGAM 193
           V +A++L P D NG SDP+V+++     K  +++ T  +K S  P WNETF F+L+E   
Sbjct: 177 VRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQLKESDK 236

Query: 194 EA-LCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRL 234
           +  L VE WDWDL SRNDF+G +   +  L+     +GWF+L
Sbjct: 237 DRRLSVEIWDWDLTSRNDFMGSLSFGISELQKA-SVDGWFKL 277



 Score = 38.1 bits (87), Expect = 0.030
 Identities = 26/90 (28%), Positives = 44/90 (48%), Gaps = 6/90 (6%)

Query: 4   RSSLYIRIVEGKNLPAKDITGSSDPYCIVKVDNEPII----RTATVWKTLCPFWGEEYQV 59
           R  L + + + KNL   D  G SDPY  +K+  +P      +T T+  +L P W E ++ 
Sbjct: 170 RDVLIVLVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRF 229

Query: 60  HLPPT--FHAVAFYVMDEDALSRDDVIGKV 87
            L  +     ++  + D D  SR+D +G +
Sbjct: 230 QLKESDKDRRLSVEIWDWDLTSRNDFMGSL 259


>gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens]
          Length = 673

 Score = 84.0 bits (206), Expect = 5e-16
 Identities = 43/102 (42%), Positives = 63/102 (61%), Gaps = 7/102 (6%)

Query: 139 VLEARDLAPKDRNGTSDPFVRVRY----KGRTRE-TSIVKKSCYPRWNETFEFELQEGAM 193
           V +A++L P D NG SDP+V+++     K  +++ T  +K S  P WNETF F+L+E   
Sbjct: 177 VRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQLKESDK 236

Query: 194 EA-LCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRL 234
           +  L VE WDWDL SRNDF+G +   +  L+     +GWF+L
Sbjct: 237 DRRLSVEIWDWDLTSRNDFMGSLSFGISELQKA-SVDGWFKL 277



 Score = 38.1 bits (87), Expect = 0.030
 Identities = 26/90 (28%), Positives = 44/90 (48%), Gaps = 6/90 (6%)

Query: 4   RSSLYIRIVEGKNLPAKDITGSSDPYCIVKVDNEPII----RTATVWKTLCPFWGEEYQV 59
           R  L + + + KNL   D  G SDPY  +K+  +P      +T T+  +L P W E ++ 
Sbjct: 170 RDVLIVLVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRF 229

Query: 60  HLPPT--FHAVAFYVMDEDALSRDDVIGKV 87
            L  +     ++  + D D  SR+D +G +
Sbjct: 230 QLKESDKDRRLSVEIWDWDLTSRNDFMGSL 259


>gi|92859638 synaptotagmin V [Homo sapiens]
          Length = 386

 Score = 84.0 bits (206), Expect = 5e-16
 Identities = 68/224 (30%), Positives = 109/224 (48%), Gaps = 16/224 (7%)

Query: 7   LYIRIVEGKNLPAKDITGSSDPYCIVKV--DNEPIIRTATVWKTLCPFWGEEYQVHLPPT 64
           L + I++   L A D+ GSSDPY  V +  D      T    +TL P +GE +   +P  
Sbjct: 125 LLVGILQAMGLAALDLGGSSDPYVRVYLLPDKRRRYETKVHRQTLNPHFGETFAFKVPYV 184

Query: 65  F---HAVAFYVMDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQ-GEI 120
                 +   V D D  SR+D IG+V +   ++    +    W  L     +E+ + G+I
Sbjct: 185 ELGGRVLVMAVYDFDRFSRNDAIGEVRVPMSSV-DLGRPVQAWRELQAAPREEQEKLGDI 243

Query: 121 HLRLEVWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRY-----KGRTRETSIVKKS 175
              L   P A   +L   VLEA++L   D  G SDP+V+V       K R ++T+I K +
Sbjct: 244 CFSLRYVPTAG--KLTVIVLEAKNLKKMDVGGLSDPYVKVHLLQGGKKVRKKKTTIKKNT 301

Query: 176 CYPRWNETFEFELQEGAMEALCVE--AWDWDLVSRNDFLGKVVI 217
             P +NE F FE+    ++ + VE    D+D + +N+ +G+V +
Sbjct: 302 LNPYYNEAFSFEVPCDQVQKVQVELTVLDYDKLGKNEAIGRVAV 345



 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 39/129 (30%), Positives = 67/129 (51%), Gaps = 9/129 (6%)

Query: 134 RLRCSVLEARDLAPKDRNGTSDPFVRVRY---KGRTRETSIVKKSCYPRWNETFEFELQ- 189
           +L   +L+A  LA  D  G+SDP+VRV     K R  ET + +++  P + ETF F++  
Sbjct: 124 QLLVGILQAMGLAALDLGGSSDPYVRVYLLPDKRRRYETKVHRQTLNPHFGETFAFKVPY 183

Query: 190 -EGAMEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGN 248
            E     L +  +D+D  SRND +G+V + +  + + +  + W  LQ     + R ++  
Sbjct: 184 VELGGRVLVMAVYDFDRFSRNDAIGEVRVPMSSVDLGRPVQAWRELQ----AAPREEQEK 239

Query: 249 LGSLQLEVR 257
           LG +   +R
Sbjct: 240 LGDICFSLR 248


>gi|28376627 synaptotagmin IX [Homo sapiens]
          Length = 491

 Score = 82.4 bits (202), Expect = 1e-15
 Identities = 66/220 (30%), Positives = 107/220 (48%), Gaps = 15/220 (6%)

Query: 7   LYIRIVEGKNLPAKDITGSSDPYCIVKV--DNEPIIRTATVWKTLCPFWGEEYQVHLPPT 64
           L ++I +  NLPAKD +G+SDPY  + +  D +   +T    KTL P + E +   +P  
Sbjct: 237 LIVKIHKAVNLPAKDFSGTSDPYVKIYLLPDRKTKHQTKVHRKTLNPVFDEVFLFPVPYN 296

Query: 65  ---FHAVAFYVMDEDALSRDDVIGKVCLTRD-TIASHPKGFSGWAHLTEVDPDEEVQGEI 120
                 + F V D D  SR D+IG+V +     +A  P+    W  +  V  D    GE+
Sbjct: 297 DLEARKLHFSVYDFDRFSRHDLIGQVVVDHFLDLADFPRECILWKDIEYVTNDNVDLGEL 356

Query: 121 HLRLEVWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRY-----KGRTRETSIVKKS 175
              L   P   A RL  ++++AR+L   D  G SDP+V+V       + + R+TS  + +
Sbjct: 357 MFSLCYLP--TAGRLTITIIKARNLKAMDITGASDPYVKVSLMCDGRRLKKRKTSTKRNT 414

Query: 176 CYPRWNETFEFELQEGAMEA--LCVEAWDWDLVSRNDFLG 213
             P +NE   F++    ++   L +   D+D V  N+ +G
Sbjct: 415 LNPVYNEAIVFDVPPENIDQIHLSIAVMDYDRVGHNEIIG 454



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 29/90 (32%), Positives = 52/90 (57%), Gaps = 5/90 (5%)

Query: 134 RLRCSVLEARDLAPKDRNGTSDPFVRVRY---KGRTRETSIVKKSCYPRWNETFEFELQE 190
           +L   + +A +L  KD +GTSDP+V++     +    +T + +K+  P ++E F F +  
Sbjct: 236 QLIVKIHKAVNLPAKDFSGTSDPYVKIYLLPDRKTKHQTKVHRKTLNPVFDEVFLFPVPY 295

Query: 191 GAMEA--LCVEAWDWDLVSRNDFLGKVVID 218
             +EA  L    +D+D  SR+D +G+VV+D
Sbjct: 296 NDLEARKLHFSVYDFDRFSRHDLIGQVVVD 325



 Score = 44.3 bits (103), Expect = 4e-04
 Identities = 33/90 (36%), Positives = 49/90 (54%), Gaps = 10/90 (11%)

Query: 7   LYIRIVEGKNLPAKDITGSSDPYCIVKV--DNEPI--IRTATVWKTLCPFWGEEYQVHLP 62
           L I I++ +NL A DITG+SDPY  V +  D   +   +T+T   TL P + E     +P
Sbjct: 369 LTITIIKARNLKAMDITGASDPYVKVSLMCDGRRLKKRKTSTKRNTLNPVYNEAIVFDVP 428

Query: 63  P----TFHAVAFYVMDEDALSRDDVIGKVC 88
           P      H ++  VMD D +  +++IG VC
Sbjct: 429 PENIDQIH-LSIAVMDYDRVGHNEIIG-VC 456


>gi|13384594 protein kinase C, gamma [Homo sapiens]
          Length = 697

 Score = 81.3 bits (199), Expect = 3e-15
 Identities = 49/119 (41%), Positives = 68/119 (57%), Gaps = 8/119 (6%)

Query: 122 LRLEVWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTR-----ETSIVKKSC 176
           L+LE+     A  +  +V EAR+L P D NG SDP+V+++     R     +T  VK + 
Sbjct: 161 LQLEI-RAPTADEIHVTVGEARNLIPMDPNGLSDPYVKLKLIPDPRNLTKQKTRTVKATL 219

Query: 177 YPRWNETFEFELQEGAMEA-LCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRL 234
            P WNETF F L+ G +E  L VE WDWD  SRNDF+G +   V  L +    +GW++L
Sbjct: 220 NPVWNETFVFNLKPGDVERRLSVEVWDWDRTSRNDFMGAMSFGVSEL-LKAPVDGWYKL 277



 Score = 44.3 bits (103), Expect = 4e-04
 Identities = 33/114 (28%), Positives = 51/114 (44%), Gaps = 8/114 (7%)

Query: 7   LYIRIVEGKNLPAKDITGSSDPYCIVKVDNEP----IIRTATVWKTLCPFWGEEYQVHLP 62
           +++ + E +NL   D  G SDPY  +K+  +P      +T TV  TL P W E +  +L 
Sbjct: 173 IHVTVGEARNLIPMDPNGLSDPYVKLKLIPDPRNLTKQKTRTVKATLNPVWNETFVFNLK 232

Query: 63  P--TFHAVAFYVMDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDE 114
           P      ++  V D D  SR+D +G +      +   P    GW  L   +  E
Sbjct: 233 PGDVERRLSVEVWDWDRTSRNDFMGAMSFGVSELLKAP--VDGWYKLLNQEEGE 284


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.135    0.406 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,879,124
Number of Sequences: 37866
Number of extensions: 1358325
Number of successful extensions: 4061
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 102
Number of HSP's successfully gapped in prelim test: 75
Number of HSP's that attempted gapping in prelim test: 3378
Number of HSP's gapped (non-prelim): 481
length of query: 757
length of database: 18,247,518
effective HSP length: 110
effective length of query: 647
effective length of database: 14,082,258
effective search space: 9111220926
effective search space used: 9111220926
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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