Search of human proteins with 239735519

Search of human proteins with 239735519

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|239735519 SET binding factor 1 [Homo sapiens]
         (1893 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|239735519 SET binding factor 1 [Homo sapiens]                     3807   0.0  
gi|29788755 SET binding factor 2 [Homo sapiens]                      2147   0.0  
gi|23510389 myotubularin-related protein 3 isoform b [Homo sapiens]   176   3e-43
gi|23510387 myotubularin-related protein 3 isoform a [Homo sapiens]   176   3e-43
gi|10835109 myotubularin-related protein 3 isoform c [Homo sapiens]   176   3e-43
gi|217272865 myotubularin related protein 4 [Homo sapiens]            150   9e-36
gi|44680154 myotubularin-related protein 2 isoform 1 [Homo sapiens]   147   1e-34
gi|41350318 myotubularin-related protein 2 isoform 2 [Homo sapiens]   147   1e-34
gi|41350316 myotubularin-related protein 2 isoform 2 [Homo sapiens]   147   1e-34
gi|4557896 myotubularin [Homo sapiens]                                141   5e-33
gi|21361759 myotubularin related protein 8 [Homo sapiens]             139   2e-32
gi|28872761 myotubularin-related protein 1 [Homo sapiens]             139   2e-32
gi|225543474 myotubularin related protein 7 [Homo sapiens]            139   3e-32
gi|148922920 DENN/MADD domain containing 4B [Homo sapiens]            128   5e-29
gi|134142348 myotubularin related protein 6 [Homo sapiens]            126   2e-28
gi|221307568 DENN/MADD domain containing 4A isoform 1 [Homo sapi...   125   5e-28
gi|221307566 DENN/MADD domain containing 4A isoform 2 [Homo sapi...   125   5e-28
gi|19923424 myotubularin related protein 9 [Homo sapiens]             118   6e-26
gi|124028527 myotubularin related protein 10 [Homo sapiens]           114   1e-24
gi|44889475 RAB6 interacting protein 1 [Homo sapiens]                 105   5e-22
gi|209863002 MAP-kinase activating death domain-containing prote...   103   2e-21
gi|209862998 MAP-kinase activating death domain-containing prote...   103   2e-21
gi|209862994 MAP-kinase activating death domain-containing prote...   103   2e-21
gi|18860873 MAP-kinase activating death domain-containing protei...   103   2e-21
gi|209862987 MAP-kinase activating death domain-containing prote...   103   2e-21
gi|209862983 MAP-kinase activating death domain-containing prote...   103   2e-21
gi|209862979 MAP-kinase activating death domain-containing prote...   103   2e-21
gi|209862975 MAP-kinase activating death domain-containing prote...   103   2e-21
gi|209862971 MAP-kinase activating death domain-containing prote...   103   2e-21
gi|209571517 MAP-kinase activating death domain-containing prote...   103   2e-21

>gi|239735519 SET binding factor 1 [Homo sapiens]
          Length = 1893

 Score = 3807 bits (9873), Expect = 0.0
 Identities = 1893/1893 (100%), Positives = 1893/1893 (100%)

Query: 1    MARLADYFVLVAFGPHPRGSGEGQGQILQRFPEKDWEDNPFPQGIELFCQPSGWQLCPER 60
            MARLADYFVLVAFGPHPRGSGEGQGQILQRFPEKDWEDNPFPQGIELFCQPSGWQLCPER
Sbjct: 1    MARLADYFVLVAFGPHPRGSGEGQGQILQRFPEKDWEDNPFPQGIELFCQPSGWQLCPER 60

Query: 61   NPPTFFVAVLTDINSERHYCACLTFWEPAEPSQETTRVEDATEREEEGDEGGQTHLSPTA 120
            NPPTFFVAVLTDINSERHYCACLTFWEPAEPSQETTRVEDATEREEEGDEGGQTHLSPTA
Sbjct: 61   NPPTFFVAVLTDINSERHYCACLTFWEPAEPSQETTRVEDATEREEEGDEGGQTHLSPTA 120

Query: 121  PAPSAQLFAPKTLVLVSRLDHTEVFRNSLGLIYAIHVEGLNVCLENVIGNLLTCTVPLAG 180
            PAPSAQLFAPKTLVLVSRLDHTEVFRNSLGLIYAIHVEGLNVCLENVIGNLLTCTVPLAG
Sbjct: 121  PAPSAQLFAPKTLVLVSRLDHTEVFRNSLGLIYAIHVEGLNVCLENVIGNLLTCTVPLAG 180

Query: 181  GSQRTISLGAGDRQVIQTPLADSLPVSRCSVALLFRQLGITNVLSLFCAALTEHKVLFLS 240
            GSQRTISLGAGDRQVIQTPLADSLPVSRCSVALLFRQLGITNVLSLFCAALTEHKVLFLS
Sbjct: 181  GSQRTISLGAGDRQVIQTPLADSLPVSRCSVALLFRQLGITNVLSLFCAALTEHKVLFLS 240

Query: 241  RSYQRLADACRGLLALLFPLRYSFTYVPILPAQLLEVLSTPTPFIIGVNAAFQAETQELL 300
            RSYQRLADACRGLLALLFPLRYSFTYVPILPAQLLEVLSTPTPFIIGVNAAFQAETQELL
Sbjct: 241  RSYQRLADACRGLLALLFPLRYSFTYVPILPAQLLEVLSTPTPFIIGVNAAFQAETQELL 300

Query: 301  DVIVADLDGGTVTIPECVHIPPLPEPLQSQTHSVLSMVLDPELELADLAFPPPTTSTSSL 360
            DVIVADLDGGTVTIPECVHIPPLPEPLQSQTHSVLSMVLDPELELADLAFPPPTTSTSSL
Sbjct: 301  DVIVADLDGGTVTIPECVHIPPLPEPLQSQTHSVLSMVLDPELELADLAFPPPTTSTSSL 360

Query: 361  KMQDKELRAVFLRLFAQLLQGYRWCLHVVRIHPEPVIRFHKAAFLGQRGLVEDDFLMKVL 420
            KMQDKELRAVFLRLFAQLLQGYRWCLHVVRIHPEPVIRFHKAAFLGQRGLVEDDFLMKVL
Sbjct: 361  KMQDKELRAVFLRLFAQLLQGYRWCLHVVRIHPEPVIRFHKAAFLGQRGLVEDDFLMKVL 420

Query: 421  EGMAFAGFVSERGVPYRPTDLFDELVAHEVARMRADENHPQRVLRHVQELAEQLYKNENP 480
            EGMAFAGFVSERGVPYRPTDLFDELVAHEVARMRADENHPQRVLRHVQELAEQLYKNENP
Sbjct: 421  EGMAFAGFVSERGVPYRPTDLFDELVAHEVARMRADENHPQRVLRHVQELAEQLYKNENP 480

Query: 481  YPAVAMHKVQRPGESSHLRRVPRPFPRLDEGTVQWIVDQAAAKMQGAPPAVKAERRTTVP 540
            YPAVAMHKVQRPGESSHLRRVPRPFPRLDEGTVQWIVDQAAAKMQGAPPAVKAERRTTVP
Sbjct: 481  YPAVAMHKVQRPGESSHLRRVPRPFPRLDEGTVQWIVDQAAAKMQGAPPAVKAERRTTVP 540

Query: 541  SGPPMTAILERCSGLHVNSARRLEVVRNCISYVFEGKMLEAKKLLPAVLRALKGRAARRC 600
            SGPPMTAILERCSGLHVNSARRLEVVRNCISYVFEGKMLEAKKLLPAVLRALKGRAARRC
Sbjct: 541  SGPPMTAILERCSGLHVNSARRLEVVRNCISYVFEGKMLEAKKLLPAVLRALKGRAARRC 600

Query: 601  LAQELHLHVQQNRAVLDHQQFDFVVRMMNCCLQDCTSLDEHGIAAALLPLVTAFCRKLSP 660
            LAQELHLHVQQNRAVLDHQQFDFVVRMMNCCLQDCTSLDEHGIAAALLPLVTAFCRKLSP
Sbjct: 601  LAQELHLHVQQNRAVLDHQQFDFVVRMMNCCLQDCTSLDEHGIAAALLPLVTAFCRKLSP 660

Query: 661  GVTQFAYSCVQEHVVWSTPQFWEAMFYGDVQTHIRALYLEPTEDLAPAQEVGEAPSQEDE 720
            GVTQFAYSCVQEHVVWSTPQFWEAMFYGDVQTHIRALYLEPTEDLAPAQEVGEAPSQEDE
Sbjct: 661  GVTQFAYSCVQEHVVWSTPQFWEAMFYGDVQTHIRALYLEPTEDLAPAQEVGEAPSQEDE 720

Query: 721  RSALDVASEQRRLWPTLSREKQQELVQKEESTVFSQAIHYANRMSYLLLPLDSSKSRLLR 780
            RSALDVASEQRRLWPTLSREKQQELVQKEESTVFSQAIHYANRMSYLLLPLDSSKSRLLR
Sbjct: 721  RSALDVASEQRRLWPTLSREKQQELVQKEESTVFSQAIHYANRMSYLLLPLDSSKSRLLR 780

Query: 781  ERAGLGDLESASNSLVTNSMAGSVAESYDTESGFEDAETCDVAGAVVRFINRFVDKVCTE 840
            ERAGLGDLESASNSLVTNSMAGSVAESYDTESGFEDAETCDVAGAVVRFINRFVDKVCTE
Sbjct: 781  ERAGLGDLESASNSLVTNSMAGSVAESYDTESGFEDAETCDVAGAVVRFINRFVDKVCTE 840

Query: 841  SGVTSDHLKGLHVMVPDIVQMHIETLEAVQRESRRLPPIQKPKLLRPRLLPGEECVLDGL 900
            SGVTSDHLKGLHVMVPDIVQMHIETLEAVQRESRRLPPIQKPKLLRPRLLPGEECVLDGL
Sbjct: 841  SGVTSDHLKGLHVMVPDIVQMHIETLEAVQRESRRLPPIQKPKLLRPRLLPGEECVLDGL 900

Query: 901  RVYLLPDGREEGAGGSAGGPALLPAEGAVFLTTYRVIFTGMPTDPLVGEQVVVRSFPVAA 960
            RVYLLPDGREEGAGGSAGGPALLPAEGAVFLTTYRVIFTGMPTDPLVGEQVVVRSFPVAA
Sbjct: 901  RVYLLPDGREEGAGGSAGGPALLPAEGAVFLTTYRVIFTGMPTDPLVGEQVVVRSFPVAA 960

Query: 961  LTKEKRISVQTPVDQLLQDGLQLRSCTFQLLKMAFDEEVGSDSAELFRKQLHKLRYPPDI 1020
            LTKEKRISVQTPVDQLLQDGLQLRSCTFQLLKMAFDEEVGSDSAELFRKQLHKLRYPPDI
Sbjct: 961  LTKEKRISVQTPVDQLLQDGLQLRSCTFQLLKMAFDEEVGSDSAELFRKQLHKLRYPPDI 1020

Query: 1021 RATFAFTLGSAHTPGRPPRVTKDKGPSLRTLSRNLVKNAKKTIGRQHVTRKKYNPPSWEH 1080
            RATFAFTLGSAHTPGRPPRVTKDKGPSLRTLSRNLVKNAKKTIGRQHVTRKKYNPPSWEH
Sbjct: 1021 RATFAFTLGSAHTPGRPPRVTKDKGPSLRTLSRNLVKNAKKTIGRQHVTRKKYNPPSWEH 1080

Query: 1081 RGQPPPEDQEDEISVSEELEPSTLTPSSALKPSDRMTMSSLVERACCRDYQRLGLGTLSS 1140
            RGQPPPEDQEDEISVSEELEPSTLTPSSALKPSDRMTMSSLVERACCRDYQRLGLGTLSS
Sbjct: 1081 RGQPPPEDQEDEISVSEELEPSTLTPSSALKPSDRMTMSSLVERACCRDYQRLGLGTLSS 1140

Query: 1141 SLSRAKSEPFRISPVNRMYAICRSYPGLLIVPQSVQDNALQRVSRCYRQNRFPVVCWRSG 1200
            SLSRAKSEPFRISPVNRMYAICRSYPGLLIVPQSVQDNALQRVSRCYRQNRFPVVCWRSG
Sbjct: 1141 SLSRAKSEPFRISPVNRMYAICRSYPGLLIVPQSVQDNALQRVSRCYRQNRFPVVCWRSG 1200

Query: 1201 RSKAVLLRSGGLHGKGVVGLFKAQNAPSPGQSQADSSSLEQEKYLQAVVSSMPRYADASG 1260
            RSKAVLLRSGGLHGKGVVGLFKAQNAPSPGQSQADSSSLEQEKYLQAVVSSMPRYADASG
Sbjct: 1201 RSKAVLLRSGGLHGKGVVGLFKAQNAPSPGQSQADSSSLEQEKYLQAVVSSMPRYADASG 1260

Query: 1261 RNTLSGFSSAHMGSHVPSPRARVTTLSNPMAASASRRTAPRGKWGSVRTSGRSSGLGTDV 1320
            RNTLSGFSSAHMGSHVPSPRARVTTLSNPMAASASRRTAPRGKWGSVRTSGRSSGLGTDV
Sbjct: 1261 RNTLSGFSSAHMGSHVPSPRARVTTLSNPMAASASRRTAPRGKWGSVRTSGRSSGLGTDV 1320

Query: 1321 GSRLAGRDALAPPQANGGPPDPGFLRPQRAALYILGDKAQLKGVRSDPLQQWELVPIEVF 1380
            GSRLAGRDALAPPQANGGPPDPGFLRPQRAALYILGDKAQLKGVRSDPLQQWELVPIEVF
Sbjct: 1321 GSRLAGRDALAPPQANGGPPDPGFLRPQRAALYILGDKAQLKGVRSDPLQQWELVPIEVF 1380

Query: 1381 EARQVKASFKKLLKACVPGCPAAEPSPASFLRSLEDSEWLIQIHKLLQVSVLVVELLDSG 1440
            EARQVKASFKKLLKACVPGCPAAEPSPASFLRSLEDSEWLIQIHKLLQVSVLVVELLDSG
Sbjct: 1381 EARQVKASFKKLLKACVPGCPAAEPSPASFLRSLEDSEWLIQIHKLLQVSVLVVELLDSG 1440

Query: 1441 SSVLVGLEDGWDITTQVVSLVQLLSDPFYRTLEGFRLLVEKEWLSFGHRFSHRGAHTLAG 1500
            SSVLVGLEDGWDITTQVVSLVQLLSDPFYRTLEGFRLLVEKEWLSFGHRFSHRGAHTLAG
Sbjct: 1441 SSVLVGLEDGWDITTQVVSLVQLLSDPFYRTLEGFRLLVEKEWLSFGHRFSHRGAHTLAG 1500

Query: 1501 QSSGFTPVFLQFLDCVHQVHLQFPMEFEFSQFYLKFLGYHHVSRRFRTFLLDSDYERIEL 1560
            QSSGFTPVFLQFLDCVHQVHLQFPMEFEFSQFYLKFLGYHHVSRRFRTFLLDSDYERIEL
Sbjct: 1501 QSSGFTPVFLQFLDCVHQVHLQFPMEFEFSQFYLKFLGYHHVSRRFRTFLLDSDYERIEL 1560

Query: 1561 GLLYEEKGERRGQVPCRSVWEYVDRLSKRTPVFHNYMYAPEDAEVLRPYSNVSNLKVWDF 1620
            GLLYEEKGERRGQVPCRSVWEYVDRLSKRTPVFHNYMYAPEDAEVLRPYSNVSNLKVWDF
Sbjct: 1561 GLLYEEKGERRGQVPCRSVWEYVDRLSKRTPVFHNYMYAPEDAEVLRPYSNVSNLKVWDF 1620

Query: 1621 YTEETLAEGPPYDWELAQGPPEPPEEERSDGGAPQSRRRVVWPCYDSCPRAQPDAISRLL 1680
            YTEETLAEGPPYDWELAQGPPEPPEEERSDGGAPQSRRRVVWPCYDSCPRAQPDAISRLL
Sbjct: 1621 YTEETLAEGPPYDWELAQGPPEPPEEERSDGGAPQSRRRVVWPCYDSCPRAQPDAISRLL 1680

Query: 1681 EELQRLETELGQPAERWKDTWDRVKAAQRLEGRPDGRGTPSSLLVSTAPHHRRSLGVYLQ 1740
            EELQRLETELGQPAERWKDTWDRVKAAQRLEGRPDGRGTPSSLLVSTAPHHRRSLGVYLQ
Sbjct: 1681 EELQRLETELGQPAERWKDTWDRVKAAQRLEGRPDGRGTPSSLLVSTAPHHRRSLGVYLQ 1740

Query: 1741 EGPVGSTLSLSLDSDQSSGSTTSGSRQAARRSTSTLYSQFQTAESENRSYEGTLYKKGAF 1800
            EGPVGSTLSLSLDSDQSSGSTTSGSRQAARRSTSTLYSQFQTAESENRSYEGTLYKKGAF
Sbjct: 1741 EGPVGSTLSLSLDSDQSSGSTTSGSRQAARRSTSTLYSQFQTAESENRSYEGTLYKKGAF 1800

Query: 1801 MKPWKARWFVLDKTKHQLRYYDHRVDTECKGVIDLAEVEAVAPGTPTMGAPKTVDEKAFF 1860
            MKPWKARWFVLDKTKHQLRYYDHRVDTECKGVIDLAEVEAVAPGTPTMGAPKTVDEKAFF
Sbjct: 1801 MKPWKARWFVLDKTKHQLRYYDHRVDTECKGVIDLAEVEAVAPGTPTMGAPKTVDEKAFF 1860

Query: 1861 DVKTTRRVYNFCAQDVPSAQQWVDRIQSCLSDA 1893
            DVKTTRRVYNFCAQDVPSAQQWVDRIQSCLSDA
Sbjct: 1861 DVKTTRRVYNFCAQDVPSAQQWVDRIQSCLSDA 1893


>gi|29788755 SET binding factor 2 [Homo sapiens]
          Length = 1849

 Score = 2147 bits (5562), Expect = 0.0
 Identities = 1116/1909 (58%), Positives = 1399/1909 (73%), Gaps = 76/1909 (3%)

Query: 1    MARLADYFVLVAFGPHPRGSGEGQGQILQRFPEKDWEDNPFPQGIELFCQPSGWQLCPER 60
            MARLADYF++V +     GSGEG G+I+QRFP+KDW+D PFPQGIELFCQP GWQL  ER
Sbjct: 1    MARLADYFIVVGYDHEKPGSGEGLGKIIQRFPQKDWDDTPFPQGIELFCQPGGWQLSRER 60

Query: 61   NPPTFFVAVLTDINSERHYCACLTFWEPAEPSQETTRVEDATEREEEGDEGGQTHLSPTA 120
              PTFFV VLTDI+S+RHYC+CLTF+E AE + + T+ E     E EG+      + P  
Sbjct: 61   KQPTFFVVVLTDIDSDRHYCSCLTFYE-AEINLQGTKKE-----EIEGEAKVSGLIQP-- 112

Query: 121  PAPSAQLFAPKTLVLVSRLDHTEVFRNSLGLIYAIHVEGLNVCLENVIGNLLTCTVPLAG 180
                A++FAPK+LVLVSRL + E+FR  LGLIY ++V+ LNV LE++I NL  C VP AG
Sbjct: 113  ----AEVFAPKSLVLVSRLYYPEIFRACLGLIYTVYVDSLNVSLESLIANLCACLVPAAG 168

Query: 181  GSQRTISLGAGDRQVIQTPLADSLPVSRCSVALLFRQLGITNVLSLFCAALTEHKVLFLS 240
            GSQ+  SLGAGDRQ+IQTPL DSLP++  SVALLF+QLGI NVLSLFCA LTE+KVLF S
Sbjct: 169  GSQKLFSLGAGDRQLIQTPLHDSLPITGTSVALLFQQLGIQNVLSLFCAVLTENKVLFHS 228

Query: 241  RSYQRLADACRGLLALLFPLRYSFTYVPILPAQLLEVLSTPTPFIIGVNAAFQAETQELL 300
             S+QRL+DACR L +L+FPL+YS+ Y+PILPAQLLEVLS+PTPFIIGV++ F+ +  ELL
Sbjct: 229  ASFQRLSDACRALESLMFPLKYSYPYIPILPAQLLEVLSSPTPFIIGVHSVFKTDVHELL 288

Query: 301  DVIVADLDGGTVTIPECVHIPPLPEPLQSQTHSVLSMVLDPELELADLAFPPPTTSTSSL 360
            DVI+ADLDGGT+ IPEC+H+  LPEPL  QT S LS++L P+LE+AD AFPPP T+ S  
Sbjct: 289  DVIIADLDGGTIKIPECIHLSSLPEPLLHQTQSALSLILHPDLEVADHAFPPPRTALSHS 348

Query: 361  KMQDKELRAVFLRLFAQLLQGYRWCLHVVRIHPEPVIRFHKAAFLGQRGLVEDDFLMKVL 420
            KM DKE+RAVFLRLFAQL QGYR CL ++RIH EPVI FHK AFLGQRGLVE+DFL KVL
Sbjct: 349  KMLDKEVRAVFLRLFAQLFQGYRSCLQLIRIHAEPVIHFHKTAFLGQRGLVENDFLTKVL 408

Query: 421  EGMAFAGFVSERGVPYRPTDLFDELVAHEVARMRADENHPQRVLRHVQELAEQLYKNENP 480
             GMAFAGFVSERG PYR  DLFDELVA EV R++ +EN+P ++++HV+ELAEQL+KNENP
Sbjct: 409  SGMAFAGFVSERGPPYRSCDLFDELVAFEVERIKVEENNPVKMIKHVRELAEQLFKNENP 468

Query: 481  YPAVAMHKVQRPGESSHLRRVPRPFPRLDEGTVQWIVDQAAAKMQGAPPAVKAERRTTVP 540
             P +A  KV RP E SHLR    PFP ++E  VQ ++ +  AK Q APPA + E++  VP
Sbjct: 469  NPHMAFQKVPRPTEGSHLRVHILPFPEINEARVQELIQENVAKNQNAPPATRIEKKCVVP 528

Query: 541  SGPPMTAILERCSGLHVNSARRLEVVRNCISYVFEGKMLEAKKLLPAVLRALKGRAARRC 600
            +GPP+ +I+++ + +  NSA+RLEVVRNCIS++FE K+LE +K LPA LRALKG+AAR+C
Sbjct: 529  AGPPVVSIMDKVTTVF-NSAQRLEVVRNCISFIFENKILETEKTLPAALRALKGKAARQC 587

Query: 601  LAQELHLHVQQNRAVLDHQQFDFVVRMMNCCLQDCTSLDEHGIAAALLPLVTAFCRKLSP 660
            L  EL LHVQQNRA+LDHQQFD+++RMMNC LQDC+SL+E+ IAAALLPL +AF RKL+P
Sbjct: 588  LTDELGLHVQQNRAILDHQQFDYIIRMMNCTLQDCSSLEEYNIAAALLPLTSAFYRKLAP 647

Query: 661  GVTQFAYSCVQEHVVWSTPQFWEAMFYGDVQTHIRALYLEPTEDL-AP-AQEVGEAPSQE 718
            GV+QFAY+CVQ+H +W+  QFWE  FY  VQ  +R+LYL   ED  AP  ++  + P   
Sbjct: 648  GVSQFAYTCVQDHPIWTNQQFWETTFYNAVQEQVRSLYLSAKEDNHAPHLKQKDKLPDDH 707

Query: 719  -DERSALDVASEQRRLWPTLSREKQQELVQKEESTVFSQAIHYANRMSYLLLPLDSSKSR 777
              E++A+D+A+EQ RLWPTLS+  QQELVQ EESTVFSQAIH+AN M  LL+PLD+SK++
Sbjct: 708  YQEKTAMDLAAEQLRLWPTLSKSTQQELVQHEESTVFSQAIHFANLMVNLLVPLDTSKNK 767

Query: 778  LLRERAGLGDLESASNSLVTNSMAGSVAESYDTESGFEDAETCDVAGAVVRFINRFVDKV 837
            LLR  A  GD ES SNS+VTNS+AGSVAESYDTESGFED+E  D+A +VVRFI RF+DKV
Sbjct: 768  LLRTSAP-GDWESGSNSIVTNSIAGSVAESYDTESGFEDSENTDIANSVVRFITRFIDKV 826

Query: 838  CTESGVTSDHLKGLHVMVPDIVQMHIETLEAVQRESRRLPPIQKPKLLRPRLLPGEECVL 897
            CTESGVT DH+K LH M+P IV MHIETLEAV RESRRLPPIQKPK+LRP LLPGEE V 
Sbjct: 827  CTESGVTQDHIKSLHCMIPGIVAMHIETLEAVHRESRRLPPIQKPKILRPALLPGEEIVC 886

Query: 898  DGLRVYLLPDGREEGAGGSAGGPALLPAEGAVFLTTYRVIFTGMPTDPLVGEQVVVRSFP 957
            +GLRV L PDGREE  GG  GGP LLPAEGA+FLTTYR++F G P D LVGEQ VVRSFP
Sbjct: 887  EGLRVLLDPDGREEATGGLLGGPQLLPAEGALFLTTYRILFRGTPHDQLVGEQTVVRSFP 946

Query: 958  VAALTKEKRISVQTPVDQLLQDGLQLRSCTFQLLKMAFDEEVGSDSAELFRKQLHKLRYP 1017
            +A++TKEK+I++Q  + Q +Q+GLQ+ S +FQL+K+AFDEEV  +  E+F+KQL K RYP
Sbjct: 947  IASITKEKKITMQNQLQQNMQEGLQITSASFQLIKVAFDEEVSPEVVEIFKKQLMKFRYP 1006

Query: 1018 PDIRATFAFTLGSAHTPGRPPRVTKDKGPSLRTLSRNLVKNAKK----TIGRQHVTRKKY 1073
              I +TFAF  G   TP       K+K  S RT S+ +VK AK+    TIGRQ++ +KK 
Sbjct: 1007 QSIFSTFAFAAGQT-TPQIILPKQKEKNTSFRTFSKTIVKGAKRAGKMTIGRQYLLKKKT 1065

Query: 1074 NPPSWEHRGQPPPEDQEDEISVSEELEPSTLTPSSALKPSDRMTMSSLVERACCRDYQRL 1133
                 E R   P  +++D++SVS+E E   L  S+ LK S++ TM  LVE+AC RDYQRL
Sbjct: 1066 GTIV-EERVNRPGWNEDDDVSVSDESE---LPTSTTLKASEKSTMEQLVEKACFRDYQRL 1121

Query: 1134 GLGTLSSSLSRAKSEPFRISPVNRMYAICRSYPGLLIVPQSVQDNALQRVSRCYRQNRFP 1193
            GLGT+S S SR++ E FRI+  NRMY++CRSYPGLL+VPQ+VQD++L RV+RCYR NR P
Sbjct: 1122 GLGTISGSSSRSRPEYFRITASNRMYSLCRSYPGLLVVPQAVQDSSLPRVARCYRHNRLP 1181

Query: 1194 VVCWRSGRSKAVLLRSGGLHGKGVVGLFKAQNAP--SPGQSQADSSSLEQEKYLQAVVSS 1251
            VVCW++ RS  +LLRSGG HGKGVVGLFK+QN+P  +P  S   SSS+EQEKYLQA++++
Sbjct: 1182 VVCWKNSRSGTLLLRSGGFHGKGVVGLFKSQNSPQAAPTSSLESSSSIEQEKYLQALLNA 1241

Query: 1252 MPRYADASGRNTLSGFSSAHMGSHVPSPRARVTTLSNPMAASASRRTAPRGKWGSVRTSG 1311
            +  +    G +TL                    T+    A S        G W S+R+S 
Sbjct: 1242 VSVHQKLRGNSTL--------------------TVRPAFALSP-------GVWASLRSST 1274

Query: 1312 RSSGLGT---DVGSRLAGRDALAPPQANGGPPDPGFLRPQRAALYILGDKAQLKGVRSDP 1368
            R     T   DVG+RLAG+D  A   +N        L+ Q AALYI G+K+QL+  + + 
Sbjct: 1275 RLISSPTSFIDVGARLAGKDHSAS-FSNSSYLQNQLLKRQ-AALYIFGEKSQLRNFKVEF 1332

Query: 1369 LQQWELVPIEVFEARQVKASFKKLLKACVPGCPAAEPSPASFLRSLEDSEWLIQIHKLLQ 1428
                E VP+E  E RQVKASFKKL++AC+P     + S  +FL++L DSEW  Q+H+++Q
Sbjct: 1333 ALNCEFVPVEFHEIRQVKASFKKLMRACIPSTIPTD-SEVTFLKALGDSEWFPQLHRIMQ 1391

Query: 1429 VSVLVVELLDSGSSVLVGLEDGWDITTQVVSLVQLLSDPFYRTLEGFRLLVEKEWLSFGH 1488
            ++V+V E+L++GSSVLV LE+GWDIT QV SLVQLLSDPFYRTLEGF++LVEKEWLSFGH
Sbjct: 1392 LAVVVSEVLENGSSVLVCLEEGWDITAQVTSLVQLLSDPFYRTLEGFQMLVEKEWLSFGH 1451

Query: 1489 RFSHRGAHTLAGQSSGFTPVFLQFLDCVHQVHLQFPMEFEFSQFYLKFLGYHHVSRRFRT 1548
            +FS R + TL  Q SGF PVFLQFLDCVHQVH Q+P EFEF+ +YLKFL +H+VS RF+T
Sbjct: 1452 KFSQRSSLTLNCQGSGFAPVFLQFLDCVHQVHNQYPTEFEFNLYYLKFLAFHYVSNRFKT 1511

Query: 1549 FLLDSDYERIELGLLYEEKGERRGQVPCRSVWEYVDRLSKRTPVFHNYMYAPEDAEVLRP 1608
            FLLDSDYER+E G L+++KGE+  +     +WE +DR+ KR+P+F NY+Y+P + E L+P
Sbjct: 1512 FLLDSDYERLEHGTLFDDKGEKHAKKGV-CIWECIDRMHKRSPIFFNYLYSPLEIEALKP 1570

Query: 1609 YSNVSNLKVWDFYTEETLAEGPPYDWELAQGPPEPPEEERSDGGA-PQSRRRVVWPCYDS 1667
              NVS+LK WD+Y EETL+ GP YDW +      P E+    G A P+S+RR VWPCYD 
Sbjct: 1571 NVNVSSLKKWDYYIEETLSTGPSYDWMMLTPKHFPSEDSDLAGEAGPRSQRRTVWPCYDD 1630

Query: 1668 CPRAQPDAISRLLEELQRLETELGQPAERWKDTWDRVKAAQRLEGRPDGRGTPSSLLVST 1727
                QPDA++ L  E+++LE +L Q  E+W+  W+RV    + E R D           +
Sbjct: 1631 VSCTQPDALTSLFSEIEKLEHKLNQAPEKWQQLWERVTVDLKEEPRTD----------RS 1680

Query: 1728 APHHRRSLGVYLQEGPVGSTLSLSLDSDQSSGSTTSGS---RQAARRSTSTLYSQFQTAE 1784
              H  RS G+     P     SL    D S G   + S        R  +TLYSQ+ +  
Sbjct: 1681 QRHLSRSPGIVSTNLPSYQKRSLLHLPDSSMGEEQNSSISPSNGVERRAATLYSQYTSKN 1740

Query: 1785 SENRSYEGTLYKKGAFMKPWKARWFVLDKTKHQLRYYDHRVDTECKGVIDLAEVEAVAPG 1844
             ENRS+EGTLYK+GA +K WK RWFVLD TKHQLRYYD   DT CKG IDLAEVE V P 
Sbjct: 1741 DENRSFEGTLYKRGALLKGWKPRWFVLDVTKHQLRYYDSGEDTSCKGHIDLAEVEMVIPA 1800

Query: 1845 TPTMGAPKTVDEKAFFDVKTTRRVYNFCAQDVPSAQQWVDRIQSCLSDA 1893
             P+MGAPK   +KAFFD+KT++RVYNFCAQD  SAQQW+D+IQSC+SDA
Sbjct: 1801 GPSMGAPKHTSDKAFFDLKTSKRVYNFCAQDGQSAQQWMDKIQSCISDA 1849


>gi|23510389 myotubularin-related protein 3 isoform b [Homo sapiens]
          Length = 1161

 Score =  176 bits (445), Expect = 3e-43
 Identities = 144/475 (30%), Positives = 220/475 (46%), Gaps = 84/475 (17%)

Query: 1150 FRISPVNRMYAICRSYPGLLIVPQSVQDNALQRVSRCYRQNRFPVVCWRSGRSKAVLLRS 1209
            +RIS +N  Y +C SYP  LIVP  + D  L+ VS      R P V +R   + AV+ R 
Sbjct: 176  WRISNINEKYKLCGSYPQELIVPAWITDKELESVSSFRSWKRIPAVIYRHQSNGAVIARC 235

Query: 1210 GGLHGKGVVGLFKAQNAPSPGQSQADSSSLEQEKYLQAVVSSMPRYADASGRNTLSGFSS 1269
                G+  V  +  +NA             + E  +Q+V  +    + +SG         
Sbjct: 236  ----GQPEVSWWGWRNA-------------DDEHLVQSVAKACASDSRSSG--------- 269

Query: 1270 AHMGSHVPSPRARVTTLSNPMAASASRRTAPRGKWGSVRTSGRSSGLGTDVGSRLAGRDA 1329
                              + ++   + R  P G  G +      S L     S  +G ++
Sbjct: 270  ------------------SKLSTRNTSRDFPNG--GDLSDVEFDSSL-----SNASGAES 304

Query: 1330 LAPPQANGGPPDPGFLRPQRAALYILGDKAQLKGVRS-DPLQQWELVPIEVFEARQVKAS 1388
            LA        P    +   R+    + ++A+  G    +     E+V + +     ++ S
Sbjct: 305  LAIQ------PQKLLILDARSYAAAVANRAKGGGCECPEYYPNCEVVFMGMANIHSIRRS 358

Query: 1389 FKKLLKACVPGCPAAEPSPASFLRSLEDSEWLIQIHKLLQVSVLVVELLDSGSS-VLVGL 1447
            F+ L   C        P P ++L +LE ++WL  +  LL+ ++LVV  +D     VLV  
Sbjct: 359  FQSLRLLCTQ-----MPDPGNWLSALESTKWLHHLSVLLKSALLVVHAVDQDQRPVLVHC 413

Query: 1448 EDGWDITTQVVSLVQLLSDPFYRTLEGFRLLVEKEWLSFGHRFSHRGAHTLAGQSSG--- 1504
             DGWD T Q+V+L +LL DP+YRT+EGF++LVE EWL FGH+F+ R  H   G++S    
Sbjct: 414  SDGWDRTPQIVALAKLLLDPYYRTIEGFQVLVEMEWLDFGHKFADRCGH---GENSDDLN 470

Query: 1505 -FTPVFLQFLDCVHQVHLQFPMEFEFSQFYLKFLGYHHVSRRFRTFLLDSDYERIELGLL 1563
               PVFLQ+LDCVHQ+  QFP  FEF++ +L  L  H  S  F TFL ++          
Sbjct: 471  ERCPVFLQWLDCVHQLQRQFPCSFEFNEAFLVKLVQHTYSCLFGTFLCNN---------- 520

Query: 1564 YEEKGERRGQVPCRSVWEYVDRLSKRTPVFHNYMYAPEDAEVLRPYSNVSNLKVW 1618
             +E+GE+  Q    SVW  +   +K    F N +Y+ +   VL P  +V NL +W
Sbjct: 521  AKERGEKHTQERTCSVWSLLRAGNK---AFKNLLYSSQSEAVLYPVCHVRNLMLW 572


>gi|23510387 myotubularin-related protein 3 isoform a [Homo sapiens]
          Length = 1170

 Score =  176 bits (445), Expect = 3e-43
 Identities = 144/475 (30%), Positives = 220/475 (46%), Gaps = 84/475 (17%)

Query: 1150 FRISPVNRMYAICRSYPGLLIVPQSVQDNALQRVSRCYRQNRFPVVCWRSGRSKAVLLRS 1209
            +RIS +N  Y +C SYP  LIVP  + D  L+ VS      R P V +R   + AV+ R 
Sbjct: 176  WRISNINEKYKLCGSYPQELIVPAWITDKELESVSSFRSWKRIPAVIYRHQSNGAVIARC 235

Query: 1210 GGLHGKGVVGLFKAQNAPSPGQSQADSSSLEQEKYLQAVVSSMPRYADASGRNTLSGFSS 1269
                G+  V  +  +NA             + E  +Q+V  +    + +SG         
Sbjct: 236  ----GQPEVSWWGWRNA-------------DDEHLVQSVAKACASDSRSSG--------- 269

Query: 1270 AHMGSHVPSPRARVTTLSNPMAASASRRTAPRGKWGSVRTSGRSSGLGTDVGSRLAGRDA 1329
                              + ++   + R  P G  G +      S L     S  +G ++
Sbjct: 270  ------------------SKLSTRNTSRDFPNG--GDLSDVEFDSSL-----SNASGAES 304

Query: 1330 LAPPQANGGPPDPGFLRPQRAALYILGDKAQLKGVRS-DPLQQWELVPIEVFEARQVKAS 1388
            LA        P    +   R+    + ++A+  G    +     E+V + +     ++ S
Sbjct: 305  LAIQ------PQKLLILDARSYAAAVANRAKGGGCECPEYYPNCEVVFMGMANIHSIRRS 358

Query: 1389 FKKLLKACVPGCPAAEPSPASFLRSLEDSEWLIQIHKLLQVSVLVVELLDSGSS-VLVGL 1447
            F+ L   C        P P ++L +LE ++WL  +  LL+ ++LVV  +D     VLV  
Sbjct: 359  FQSLRLLCTQ-----MPDPGNWLSALESTKWLHHLSVLLKSALLVVHAVDQDQRPVLVHC 413

Query: 1448 EDGWDITTQVVSLVQLLSDPFYRTLEGFRLLVEKEWLSFGHRFSHRGAHTLAGQSSG--- 1504
             DGWD T Q+V+L +LL DP+YRT+EGF++LVE EWL FGH+F+ R  H   G++S    
Sbjct: 414  SDGWDRTPQIVALAKLLLDPYYRTIEGFQVLVEMEWLDFGHKFADRCGH---GENSDDLN 470

Query: 1505 -FTPVFLQFLDCVHQVHLQFPMEFEFSQFYLKFLGYHHVSRRFRTFLLDSDYERIELGLL 1563
               PVFLQ+LDCVHQ+  QFP  FEF++ +L  L  H  S  F TFL ++          
Sbjct: 471  ERCPVFLQWLDCVHQLQRQFPCSFEFNEAFLVKLVQHTYSCLFGTFLCNN---------- 520

Query: 1564 YEEKGERRGQVPCRSVWEYVDRLSKRTPVFHNYMYAPEDAEVLRPYSNVSNLKVW 1618
             +E+GE+  Q    SVW  +   +K    F N +Y+ +   VL P  +V NL +W
Sbjct: 521  AKERGEKHTQERTCSVWSLLRAGNK---AFKNLLYSSQSEAVLYPVCHVRNLMLW 572


>gi|10835109 myotubularin-related protein 3 isoform c [Homo sapiens]
          Length = 1198

 Score =  176 bits (445), Expect = 3e-43
 Identities = 144/475 (30%), Positives = 220/475 (46%), Gaps = 84/475 (17%)

Query: 1150 FRISPVNRMYAICRSYPGLLIVPQSVQDNALQRVSRCYRQNRFPVVCWRSGRSKAVLLRS 1209
            +RIS +N  Y +C SYP  LIVP  + D  L+ VS      R P V +R   + AV+ R 
Sbjct: 176  WRISNINEKYKLCGSYPQELIVPAWITDKELESVSSFRSWKRIPAVIYRHQSNGAVIARC 235

Query: 1210 GGLHGKGVVGLFKAQNAPSPGQSQADSSSLEQEKYLQAVVSSMPRYADASGRNTLSGFSS 1269
                G+  V  +  +NA             + E  +Q+V  +    + +SG         
Sbjct: 236  ----GQPEVSWWGWRNA-------------DDEHLVQSVAKACASDSRSSG--------- 269

Query: 1270 AHMGSHVPSPRARVTTLSNPMAASASRRTAPRGKWGSVRTSGRSSGLGTDVGSRLAGRDA 1329
                              + ++   + R  P G  G +      S L     S  +G ++
Sbjct: 270  ------------------SKLSTRNTSRDFPNG--GDLSDVEFDSSL-----SNASGAES 304

Query: 1330 LAPPQANGGPPDPGFLRPQRAALYILGDKAQLKGVRS-DPLQQWELVPIEVFEARQVKAS 1388
            LA        P    +   R+    + ++A+  G    +     E+V + +     ++ S
Sbjct: 305  LAIQ------PQKLLILDARSYAAAVANRAKGGGCECPEYYPNCEVVFMGMANIHSIRRS 358

Query: 1389 FKKLLKACVPGCPAAEPSPASFLRSLEDSEWLIQIHKLLQVSVLVVELLDSGSS-VLVGL 1447
            F+ L   C        P P ++L +LE ++WL  +  LL+ ++LVV  +D     VLV  
Sbjct: 359  FQSLRLLCTQ-----MPDPGNWLSALESTKWLHHLSVLLKSALLVVHAVDQDQRPVLVHC 413

Query: 1448 EDGWDITTQVVSLVQLLSDPFYRTLEGFRLLVEKEWLSFGHRFSHRGAHTLAGQSSG--- 1504
             DGWD T Q+V+L +LL DP+YRT+EGF++LVE EWL FGH+F+ R  H   G++S    
Sbjct: 414  SDGWDRTPQIVALAKLLLDPYYRTIEGFQVLVEMEWLDFGHKFADRCGH---GENSDDLN 470

Query: 1505 -FTPVFLQFLDCVHQVHLQFPMEFEFSQFYLKFLGYHHVSRRFRTFLLDSDYERIELGLL 1563
               PVFLQ+LDCVHQ+  QFP  FEF++ +L  L  H  S  F TFL ++          
Sbjct: 471  ERCPVFLQWLDCVHQLQRQFPCSFEFNEAFLVKLVQHTYSCLFGTFLCNN---------- 520

Query: 1564 YEEKGERRGQVPCRSVWEYVDRLSKRTPVFHNYMYAPEDAEVLRPYSNVSNLKVW 1618
             +E+GE+  Q    SVW  +   +K    F N +Y+ +   VL P  +V NL +W
Sbjct: 521  AKERGEKHTQERTCSVWSLLRAGNK---AFKNLLYSSQSEAVLYPVCHVRNLMLW 572


>gi|217272865 myotubularin related protein 4 [Homo sapiens]
          Length = 1195

 Score =  150 bits (380), Expect = 9e-36
 Identities = 94/248 (37%), Positives = 138/248 (55%), Gaps = 20/248 (8%)

Query: 1373 ELVPIEVFEARQVKASFKKLLKACVPGCPAAEPSPASFLRSLEDSEWLIQIHKLLQVSVL 1432
            E+V + +     ++ SF+ L   C     +  P P+++L +LE ++WL  +  +L+ +VL
Sbjct: 337  EVVFMGMANIHAIRNSFQYLRAVC-----SQMPDPSNWLSALESTKWLQHLSVMLKAAVL 391

Query: 1433 VVELLD-SGSSVLVGLEDGWDITTQVVSLVQLLSDPFYRTLEGFRLLVEKEWLSFGHRFS 1491
            V   +D  G  VLV   DGWD T Q+V+L ++L DP+YRTLEGF++LVE +WL FGH+F 
Sbjct: 392  VANTVDREGRPVLVHCSDGWDRTPQIVALAKILLDPYYRTLEGFQVLVESDWLDFGHKFG 451

Query: 1492 HRGAH-TLAGQSSGFTPVFLQFLDCVHQVHLQFPMEFEFSQFYLKFLGYHHVSRRFRTFL 1550
             R  H       +   PVFLQ+LD VHQ+  QFP  FEF++ +L  L  H  S  + TFL
Sbjct: 452  DRCGHQENVEDQNEQCPVFLQWLDSVHQLLKQFPCLFEFNEAFLVKLVQHTYSCLYGTFL 511

Query: 1551 LDSDYERIELGLLYEEKGERRGQVPCRSVWEYVDRLSKRTPVFHNYMYAPEDAEVLRPYS 1610
             ++  ER E   +Y+          C SVW  +   +K    FHN++Y P    VL P  
Sbjct: 512  ANNPCER-EKRNIYKR--------TC-SVWALLRAGNKN---FHNFLYTPSSDMVLHPVC 558

Query: 1611 NVSNLKVW 1618
            +V  L +W
Sbjct: 559  HVRALHLW 566



 Score = 44.3 bits (103), Expect = 0.001
 Identities = 22/59 (37%), Positives = 33/59 (55%)

Query: 1150 FRISPVNRMYAICRSYPGLLIVPQSVQDNALQRVSRCYRQNRFPVVCWRSGRSKAVLLR 1208
            +R+S +N  Y +C SYP  L+VP  + D  L+ V+      R PVV +R  R+ A + R
Sbjct: 174  WRVSHINSNYKLCPSYPQKLLVPVWITDKELENVASFRSWKRIPVVVYRHLRNGAAIAR 232


>gi|44680154 myotubularin-related protein 2 isoform 1 [Homo sapiens]
          Length = 643

 Score =  147 bits (370), Expect = 1e-34
 Identities = 94/281 (33%), Positives = 151/281 (53%), Gaps = 21/281 (7%)

Query: 1344 FLRPQRAALYILGDKAQLKGVRS-DPLQQWELVPIEVFEARQVKASFKKLLKACVPGCPA 1402
            F+   R ++  + +KA+  G  S D  Q  ELV +++     ++ S +KL +   P    
Sbjct: 317  FIFDARPSVNAVANKAKGGGYESEDAYQNAELVFLDIHNIHVMRESLRKLKEIVYPNIEE 376

Query: 1403 AEPSPASFLRSLEDSEWLIQIHKLLQVSVLVVELLDSG-SSVLVGLEDGWDITTQVVSLV 1461
                   +L +LE + WL  I  +L  ++ + + ++SG +SV+V   DGWD T Q+ SL 
Sbjct: 377  TH-----WLSNLESTHWLEHIKLILAGALRIADKVESGKTSVVVHCSDGWDRTAQLTSLA 431

Query: 1462 QLLSDPFYRTLEGFRLLVEKEWLSFGHRFSHRGAHTLAGQS-SGFTPVFLQFLDCVHQVH 1520
             L+ D +YRT+ GF +LVEKEWLSFGHRF  R  H     + +  +PVFLQF+DCV Q+ 
Sbjct: 432  MLMLDGYYRTIRGFEVLVEKEWLSFGHRFQLRVGHGDKNHADADRSPVFLQFIDCVWQMT 491

Query: 1521 LQFPMEFEFSQFYLKFLGYHHVSRRFRTFLLDSDYERIELGLLYEEKGERRGQVPCRSVW 1580
             QFP  FEF++++L  +  H  S  F TFL +S+          +++G+        S+W
Sbjct: 492  RQFPTAFEFNEYFLITILDHLYSCLFGTFLCNSE----------QQRGKENLPKRTVSLW 541

Query: 1581 EYVDRLSKRTPVFHNYMYAPEDAEVLRPYSNVSNLKVWDFY 1621
             Y+   + +   F N +Y      VL P +++ +L++W  Y
Sbjct: 542  SYI---NSQLEDFTNPLYGSYSNHVLYPVASMRHLELWVGY 579



 Score = 59.7 bits (143), Expect = 3e-08
 Identities = 33/105 (31%), Positives = 51/105 (48%), Gaps = 17/105 (16%)

Query: 1147 SEPFRISPVNRMYAICRSYPGLLIVPQSVQDNALQRVSRCYRQNRFPVVCWRSGRSKAVL 1206
            +E +RI+ +N  Y +C +YP LL+VP ++ D  L+RV+    + R PV+ W    S+A +
Sbjct: 222  NESWRITKINERYELCDTYPALLVVPANIPDEELKRVASFRSRGRIPVLSWIHPESQATI 281

Query: 1207 LRSGGLHGKGVVGLFKAQNAPSPGQSQADSSSLEQEKYLQAVVSS 1251
             R                    P    +   S E EKYLQA++ S
Sbjct: 282  TR-----------------CSQPMVGVSGKRSKEDEKYLQAIMDS 309


>gi|41350318 myotubularin-related protein 2 isoform 2 [Homo sapiens]
          Length = 571

 Score =  147 bits (370), Expect = 1e-34
 Identities = 94/281 (33%), Positives = 151/281 (53%), Gaps = 21/281 (7%)

Query: 1344 FLRPQRAALYILGDKAQLKGVRS-DPLQQWELVPIEVFEARQVKASFKKLLKACVPGCPA 1402
            F+   R ++  + +KA+  G  S D  Q  ELV +++     ++ S +KL +   P    
Sbjct: 245  FIFDARPSVNAVANKAKGGGYESEDAYQNAELVFLDIHNIHVMRESLRKLKEIVYPNIEE 304

Query: 1403 AEPSPASFLRSLEDSEWLIQIHKLLQVSVLVVELLDSG-SSVLVGLEDGWDITTQVVSLV 1461
                   +L +LE + WL  I  +L  ++ + + ++SG +SV+V   DGWD T Q+ SL 
Sbjct: 305  TH-----WLSNLESTHWLEHIKLILAGALRIADKVESGKTSVVVHCSDGWDRTAQLTSLA 359

Query: 1462 QLLSDPFYRTLEGFRLLVEKEWLSFGHRFSHRGAHTLAGQS-SGFTPVFLQFLDCVHQVH 1520
             L+ D +YRT+ GF +LVEKEWLSFGHRF  R  H     + +  +PVFLQF+DCV Q+ 
Sbjct: 360  MLMLDGYYRTIRGFEVLVEKEWLSFGHRFQLRVGHGDKNHADADRSPVFLQFIDCVWQMT 419

Query: 1521 LQFPMEFEFSQFYLKFLGYHHVSRRFRTFLLDSDYERIELGLLYEEKGERRGQVPCRSVW 1580
             QFP  FEF++++L  +  H  S  F TFL +S+          +++G+        S+W
Sbjct: 420  RQFPTAFEFNEYFLITILDHLYSCLFGTFLCNSE----------QQRGKENLPKRTVSLW 469

Query: 1581 EYVDRLSKRTPVFHNYMYAPEDAEVLRPYSNVSNLKVWDFY 1621
             Y+   + +   F N +Y      VL P +++ +L++W  Y
Sbjct: 470  SYI---NSQLEDFTNPLYGSYSNHVLYPVASMRHLELWVGY 507



 Score = 59.7 bits (143), Expect = 3e-08
 Identities = 33/105 (31%), Positives = 51/105 (48%), Gaps = 17/105 (16%)

Query: 1147 SEPFRISPVNRMYAICRSYPGLLIVPQSVQDNALQRVSRCYRQNRFPVVCWRSGRSKAVL 1206
            +E +RI+ +N  Y +C +YP LL+VP ++ D  L+RV+    + R PV+ W    S+A +
Sbjct: 150  NESWRITKINERYELCDTYPALLVVPANIPDEELKRVASFRSRGRIPVLSWIHPESQATI 209

Query: 1207 LRSGGLHGKGVVGLFKAQNAPSPGQSQADSSSLEQEKYLQAVVSS 1251
             R                    P    +   S E EKYLQA++ S
Sbjct: 210  TR-----------------CSQPMVGVSGKRSKEDEKYLQAIMDS 237


>gi|41350316 myotubularin-related protein 2 isoform 2 [Homo sapiens]
          Length = 571

 Score =  147 bits (370), Expect = 1e-34
 Identities = 94/281 (33%), Positives = 151/281 (53%), Gaps = 21/281 (7%)

Query: 1344 FLRPQRAALYILGDKAQLKGVRS-DPLQQWELVPIEVFEARQVKASFKKLLKACVPGCPA 1402
            F+   R ++  + +KA+  G  S D  Q  ELV +++     ++ S +KL +   P    
Sbjct: 245  FIFDARPSVNAVANKAKGGGYESEDAYQNAELVFLDIHNIHVMRESLRKLKEIVYPNIEE 304

Query: 1403 AEPSPASFLRSLEDSEWLIQIHKLLQVSVLVVELLDSG-SSVLVGLEDGWDITTQVVSLV 1461
                   +L +LE + WL  I  +L  ++ + + ++SG +SV+V   DGWD T Q+ SL 
Sbjct: 305  TH-----WLSNLESTHWLEHIKLILAGALRIADKVESGKTSVVVHCSDGWDRTAQLTSLA 359

Query: 1462 QLLSDPFYRTLEGFRLLVEKEWLSFGHRFSHRGAHTLAGQS-SGFTPVFLQFLDCVHQVH 1520
             L+ D +YRT+ GF +LVEKEWLSFGHRF  R  H     + +  +PVFLQF+DCV Q+ 
Sbjct: 360  MLMLDGYYRTIRGFEVLVEKEWLSFGHRFQLRVGHGDKNHADADRSPVFLQFIDCVWQMT 419

Query: 1521 LQFPMEFEFSQFYLKFLGYHHVSRRFRTFLLDSDYERIELGLLYEEKGERRGQVPCRSVW 1580
             QFP  FEF++++L  +  H  S  F TFL +S+          +++G+        S+W
Sbjct: 420  RQFPTAFEFNEYFLITILDHLYSCLFGTFLCNSE----------QQRGKENLPKRTVSLW 469

Query: 1581 EYVDRLSKRTPVFHNYMYAPEDAEVLRPYSNVSNLKVWDFY 1621
             Y+   + +   F N +Y      VL P +++ +L++W  Y
Sbjct: 470  SYI---NSQLEDFTNPLYGSYSNHVLYPVASMRHLELWVGY 507



 Score = 59.7 bits (143), Expect = 3e-08
 Identities = 33/105 (31%), Positives = 51/105 (48%), Gaps = 17/105 (16%)

Query: 1147 SEPFRISPVNRMYAICRSYPGLLIVPQSVQDNALQRVSRCYRQNRFPVVCWRSGRSKAVL 1206
            +E +RI+ +N  Y +C +YP LL+VP ++ D  L+RV+    + R PV+ W    S+A +
Sbjct: 150  NESWRITKINERYELCDTYPALLVVPANIPDEELKRVASFRSRGRIPVLSWIHPESQATI 209

Query: 1207 LRSGGLHGKGVVGLFKAQNAPSPGQSQADSSSLEQEKYLQAVVSS 1251
             R                    P    +   S E EKYLQA++ S
Sbjct: 210  TR-----------------CSQPMVGVSGKRSKEDEKYLQAIMDS 237


>gi|4557896 myotubularin [Homo sapiens]
          Length = 603

 Score =  141 bits (356), Expect = 5e-33
 Identities = 95/278 (34%), Positives = 145/278 (52%), Gaps = 25/278 (8%)

Query: 1349 RAALYILGDKAQLKGVRSDPL-QQWELVPIEVFEARQVKASFKKLLKACVPGCPAAEPSP 1407
            R ++  + +KA   G  SD      EL  +++     ++ S KK+     P    +    
Sbjct: 280  RPSVNAVANKATGGGYESDDAYHNAELFFLDIHNIHVMRESLKKVKDIVYPNVEESH--- 336

Query: 1408 ASFLRSLEDSEWLIQIHKLLQVSVLVVELLDSG-SSVLVGLEDGWDITTQVVSLVQLLSD 1466
              +L SLE + WL  I  +L  ++ V + + SG SSVLV   DGWD T Q+ SL  L+ D
Sbjct: 337  --WLSSLESTHWLEHIKLVLTGAIQVADKVSSGKSSVLVHCSDGWDRTAQLTSLAMLMLD 394

Query: 1467 PFYRTLEGFRLLVEKEWLSFGHRFSHRGAHTLAGQS-SGFTPVFLQFLDCVHQVHLQFPM 1525
             FYR++EGF +LV+KEW+SFGH+F+ R  H     + +  +P+FLQF+DCV Q+  QFP 
Sbjct: 395  SFYRSIEGFEILVQKEWISFGHKFASRIGHGDKNHTDADRSPIFLQFIDCVWQMSKQFPT 454

Query: 1526 EFEFSQFYLKFLGYHHVSRRFRTFLLDSDYERIELGLLYEEKGERRGQVPCR--SVWEYV 1583
             FEF++ +L  +  H  S RF TFL +             E    R +V  R  S+W  +
Sbjct: 455  AFEFNEQFLIIILDHLYSCRFGTFLFNC------------ESARERQKVTERTVSLWSLI 502

Query: 1584 DRLSKRTPVFHNYMYAPEDAEVLRPYSNVSNLKVWDFY 1621
            +   ++   F N  Y  E   VL P +++ +L++W  Y
Sbjct: 503  NSNKEK---FKNPFYTKEINRVLYPVASMRHLELWVNY 537



 Score = 54.3 bits (129), Expect = 1e-06
 Identities = 26/70 (37%), Positives = 42/70 (60%), Gaps = 4/70 (5%)

Query: 1150 FRISPVNRMYAICRSYPGLLIVPQSVQDNALQRVSRCYRQNRFPVVCWRSGRSKAVLLRS 1209
            +RI+ +N+ Y +C +YP LL+VP    D+ L+RV+    +NR PV+ W    +K V++R 
Sbjct: 183  WRITFINKCYELCDTYPALLVVPYRASDDDLRRVATFRSRNRIPVLSWIHPENKTVIVRC 242

Query: 1210 G----GLHGK 1215
                 G+ GK
Sbjct: 243  SQPLVGMSGK 252


>gi|21361759 myotubularin related protein 8 [Homo sapiens]
          Length = 704

 Score =  139 bits (351), Expect = 2e-32
 Identities = 87/236 (36%), Positives = 128/236 (54%), Gaps = 20/236 (8%)

Query: 1385 VKASFKKLLKACVPGCPAAEPSPASFLRSLEDSEWLIQIHKLLQVSVLVVELLD-SGSSV 1443
            +++S +KLL+ C        P+ + FL  LE S WL  I  ++   + + + +    +SV
Sbjct: 279  MRSSLQKLLEVC----ELKTPTMSEFLSGLESSGWLRHIKAIMDAGIFITKAVKVEKASV 334

Query: 1444 LVGLEDGWDITTQVVSLVQLLSDPFYRTLEGFRLLVEKEWLSFGHRFSHRGAHTLAGQSS 1503
            LV   DGWD T QV S+  +L DPFYRT +G  +L+EKEW+S GH+FS R  H L G S 
Sbjct: 335  LVHCSDGWDRTAQVCSVASILLDPFYRTFKGLMILIEKEWISMGHKFSQRCGH-LDGDSK 393

Query: 1504 GFTPVFLQFLDCVHQVHLQFPMEFEFSQFYLKFLGYHHVSRRFRTFLLDSDYERIELGLL 1563
              +P+F QFLDC+ Q+  QFP  FEF++ +L  +  H  S +F  FL +   +R +L  +
Sbjct: 394  EVSPIFTQFLDCIWQLMEQFPCAFEFNENFLLEIHDHVFSCQFGNFLGNCQKDREDL-RV 452

Query: 1564 YEEKGERRGQVPCRSVWEYVDRLSKRTPVFHNYMYAPEDA-EVLRPYSNVSNLKVW 1618
            YE+           SVW +   L +R P F N +Y       VL P +   N++ W
Sbjct: 453  YEK---------THSVWPF---LVQRKPDFRNPLYKGFTMYGVLNPSTVPYNIQFW 496



 Score = 35.4 bits (80), Expect = 0.53
 Identities = 18/57 (31%), Positives = 30/57 (52%)

Query: 1152 ISPVNRMYAICRSYPGLLIVPQSVQDNALQRVSRCYRQNRFPVVCWRSGRSKAVLLR 1208
            I+  NR Y IC +YP  ++VP+SV    +   S+   + R PV+ +    + A + R
Sbjct: 148  ITDANRNYEICSTYPPEIVVPKSVTLGTVVGSSKFRSKERVPVLSYLYKENNAAICR 204


>gi|28872761 myotubularin-related protein 1 [Homo sapiens]
          Length = 665

 Score =  139 bits (351), Expect = 2e-32
 Identities = 85/251 (33%), Positives = 137/251 (54%), Gaps = 20/251 (7%)

Query: 1373 ELVPIEVFEARQVKASFKKLLKACVPGCPAAEPSPASFLRSLEDSEWLIQIHKLLQVSVL 1432
            ELV +E+     ++ S +KL +   P    A      +L +++ + WL  I  LL  +V 
Sbjct: 368  ELVFLEIHNIHVMRESLRKLKEIVYPSIDEAR-----WLSNVDGTHWLEYIRMLLAGAVR 422

Query: 1433 VVELLDSG-SSVLVGLEDGWDITTQVVSLVQLLSDPFYRTLEGFRLLVEKEWLSFGHRFS 1491
            + + ++SG +SV+V   DGWD T Q+ SL  L+ D +YRT++GF  LVEKEW+SFGHRF+
Sbjct: 423  IADKIESGKTSVVVHCSDGWDRTAQLTSLAMLMLDSYYRTIKGFETLVEKEWISFGHRFA 482

Query: 1492 HRGAHTLAGQS-SGFTPVFLQFLDCVHQVHLQFPMEFEFSQFYLKFLGYHHVSRRFRTFL 1550
             R  H     + +  +P+FLQF+DCV Q+  QFP  FEF++ +L  +  H  S  F TFL
Sbjct: 483  LRVGHGNDNHADADRSPIFLQFVDCVWQMTRQFPSAFEFNELFLITILDHLYSCLFGTFL 542

Query: 1551 LDSDYERIELGLLYEEKGERRGQVPCRSVWEYVDRLSKRTPVFHNYMYAPEDAEVLRPYS 1610
             + + +R +  +               S+W Y+   + +   F N  +   +  VL P +
Sbjct: 543  CNCEQQRFKEDV----------YTKTISLWSYI---NSQLDEFSNPFFVNYENHVLYPVA 589

Query: 1611 NVSNLKVWDFY 1621
            ++S+L++W  Y
Sbjct: 590  SLSHLELWVNY 600



 Score = 54.3 bits (129), Expect = 1e-06
 Identities = 34/123 (27%), Positives = 55/123 (44%), Gaps = 27/123 (21%)

Query: 1129 DYQRLGLGTLSSSLSRAKSEPFRISPVNRMYAICRSYPGLLIVPQSVQDNALQRVSRCYR 1188
            +Y+R GL           +E ++IS +N  Y  C +YP +++VP SV+D+ L +V+    
Sbjct: 235  EYKRQGL----------PNESWKISKINSNYEFCDTYPAIIVVPTSVKDDDLSKVAAFRA 284

Query: 1189 QNRFPVVCWRSGRSKAVLLRSGGLHGKGVVGLFKAQNAPSPGQSQADSSSLEQEKYLQAV 1248
            + R PV+ W    S+A + R                    P     D    E EKYLQ +
Sbjct: 285  KGRVPVLSWIHPESQATITR-----------------CSQPLVGPNDKRCKEDEKYLQTI 327

Query: 1249 VSS 1251
            + +
Sbjct: 328  MDA 330


>gi|225543474 myotubularin related protein 7 [Homo sapiens]
          Length = 660

 Score =  139 bits (350), Expect = 3e-32
 Identities = 81/214 (37%), Positives = 122/214 (57%), Gaps = 7/214 (3%)

Query: 1349 RAALYILGDKAQLKGVRS-DPLQQWELVPIEVFEARQVKASFKKLLKACVPGCPAAEPSP 1407
            R  L  + ++A  KG  + D     +   I +     ++ S +K+L+ C        PS 
Sbjct: 242  RPKLNAMANRAAGKGYENEDNYSNIKFQFIGIENIHVMRNSLQKMLEVC----ELKSPSM 297

Query: 1408 ASFLRSLEDSEWLIQIHKLLQVSVLVVELL-DSGSSVLVGLEDGWDITTQVVSLVQLLSD 1466
            + FL  LE+S WL  I  ++   + + + + + G+SVLV   DGWD T QV S+  LL D
Sbjct: 298  SDFLWGLENSGWLRHIKAIMDAGIFIAKAVSEEGASVLVHCSDGWDRTAQVCSVASLLLD 357

Query: 1467 PFYRTLEGFRLLVEKEWLSFGHRFSHRGAHTLAGQSSGFTPVFLQFLDCVHQVHLQFPME 1526
            P YRTL+GF +L+EK+W+SFGH+F+HR  + L G     +PV  QF++CV Q+  QFP  
Sbjct: 358  PHYRTLKGFMVLIEKDWISFGHKFNHRYGN-LDGDPKEISPVIDQFIECVWQLMEQFPCA 416

Query: 1527 FEFSQFYLKFLGYHHVSRRFRTFLLDSDYERIEL 1560
            FEF++ +L  + +H  S +F  FL +S  ER EL
Sbjct: 417  FEFNERFLIHIQHHIYSCQFGNFLCNSQKERREL 450



 Score = 40.8 bits (94), Expect = 0.013
 Identities = 35/125 (28%), Positives = 56/125 (44%), Gaps = 28/125 (22%)

Query: 1129 DYQRLGLGTLSSSLSRAKSEPFRISPVNRMYAICRSYPGLLIVPQSVQDNALQRVSRCYR 1188
            +Y R+GL           +  +++S VNR Y +C SYP  L VP+S   + +   S+   
Sbjct: 135  EYTRMGL----------PNHYWQLSDVNRDYRVCDSYPTELYVPKSATAHIIVGSSKFRS 184

Query: 1189 QNRFPVVCWRSGRSKAVLLRSGGLHGKGVVGLFKAQNAPSPGQSQADSSSLEQEKYLQAV 1248
            + RFPV+ +    + A + RS               + P  G S   +  LE E+ LQA+
Sbjct: 185  RRRFPVLSYYYKDNHASICRS---------------SQPLSGFS---ARCLEDEQMLQAI 226

Query: 1249 VSSMP 1253
              + P
Sbjct: 227  RKANP 231


>gi|148922920 DENN/MADD domain containing 4B [Homo sapiens]
          Length = 1496

 Score =  128 bits (322), Expect = 5e-29
 Identities = 117/437 (26%), Positives = 181/437 (41%), Gaps = 42/437 (9%)

Query: 24  QGQILQRFPEKDWEDNPFPQGIELFCQPSG-----WQLCPERNPPTFFVAVLTDINSERH 78
           + ++L R+PE+D E  P P+ + +FC P G     W    +   P F   VLT    ++ 
Sbjct: 212 EAELLGRYPEEDNEAFPLPESVPVFCLPMGATIECWPAQTKYPVPVFSTFVLTGAAGDKV 271

Query: 79  YCACLTFWEP---AEPSQETTRVEDATEREEEGDE-GGQTHLSPTAPAPSAQLFAPKTLV 134
           Y A L F+E    A  S+   R        E G   GG+   S  A            + 
Sbjct: 272 YGAALQFYEAFPRARLSERQARALGLLSAVERGRALGGRAVRSRRA------------IA 319

Query: 135 LVSRLDHTEVFRNSLGLIYAIHVEGLN-VCLENVIGNLL-TCTVPLAGGSQRTISLGAGD 192
           ++SR      FR  L  +Y   V G + + LE  I + +     P     +  + +   D
Sbjct: 320 VLSRWPAFPAFRAFLTFLYRYSVSGPHRLPLEAHISHFIHNVPFPSPQRPRILVQMSPYD 379

Query: 193 RQVIQTPLADSLPVSRCSVALLFRQLGITNVLSLFCAALTEHKVLFLSRSYQRLADACRG 252
             ++  P++  LP+S  S   L + LG    ++L  A LTEHK+L  S     L   C  
Sbjct: 380 NLLLCQPVSSPLPLSGASFLQLLQSLGPELAITLLLAVLTEHKLLVHSLRPDLLTSVCEA 439

Query: 253 LLALLFPLRYSFTYVPILPAQLLEVLSTPTPFIIGVNAAFQAETQELLDVIVADLDGGTV 312
           L++++FPL +   Y+P+ P  L +VLS P PFI+G+++++        DVI  DLD  T+
Sbjct: 440 LVSMIFPLHWQCPYIPLCPLVLADVLSAPVPFIVGIHSSYFDLHDPPADVICVDLDTNTL 499

Query: 313 TIPECVHIPPLPEPLQSQTHSVLSMVLDPELELADLAFPPPTTSTS-------------S 359
              E   +   P  L  + + VL   L    +  D  +  P    S              
Sbjct: 500 FQTEEKKLLS-PRTLPRRPYKVLLATLTNLYQQLDQTYTGPEEEASLEFLLTDYEAVCGR 558

Query: 360 LKMQDKELRAVFLRLFAQLLQGYRWCLHVVRIHPEPVIR-----FHKAAFLGQRGLVEDD 414
               ++E++  FLR  A LL+GYR  L  +   P    R     F    FL  R      
Sbjct: 559 RARLEREVQGAFLRFMACLLKGYRVFLRPLTQAPSEGARDVDNLFFLQGFLKSRERSSHK 618

Query: 415 FLMKVLEGMAFAGFVSE 431
              ++L    F+ F+ E
Sbjct: 619 LYSQLLHTQMFSQFIEE 635


>gi|134142348 myotubularin related protein 6 [Homo sapiens]
          Length = 621

 Score =  126 bits (316), Expect = 2e-28
 Identities = 96/281 (34%), Positives = 145/281 (51%), Gaps = 26/281 (9%)

Query: 1344 FLRPQRAALYILGDKAQLKGVRSDPLQ---QWELVPIEVFEARQVKASFKKLLKACVPGC 1400
            ++   R  L  + ++A  KG  ++      +++ V IE      +++S +KLL+  V G 
Sbjct: 235  YVMDTRPKLNAMANRAAGKGYENEDNYSNIRFQFVGIENIHV--MRSSLQKLLE--VNGT 290

Query: 1401 PAAEPSPASFLRSLEDSEWLIQIHKLLQVSVLVVELLD-SGSSVLVGLEDGWDITTQVVS 1459
                 S   F   LE S WL  I  ++  ++ + + +    +SVLV   DGWD T+QV S
Sbjct: 291  KGL--SVNDFYSGLESSGWLRHIKAVMDAAIFLAKAITVENASVLVHCSDGWDRTSQVCS 348

Query: 1460 LVQLLSDPFYRTLEGFRLLVEKEWLSFGHRFSHRGAHTLAGQSSGFTPVFLQFLDCVHQV 1519
            L  LL D +YRT++GF +L+EK+W+SFGH+FS R    L G     +PVF QFL+CV  +
Sbjct: 349  LGSLLLDSYYRTIKGFMVLIEKDWISFGHKFSER-CGQLDGDPKEVSPVFTQFLECVWHL 407

Query: 1520 HLQFPMEFEFSQFYLKFLGYHHVSRRFRTFLLDSDYERIELGLLYEEKGERRGQVPCRSV 1579
              QFP  FEFS+ +L  +  H  S +F  FL +   ER EL L  +EK          S+
Sbjct: 408  TEQFPQAFEFSEAFLLQIHEHIHSCQFGNFLGNCQKEREELKL--KEK--------TYSL 457

Query: 1580 WEYVDRLSKRTPVFHNYMYAPEDAE--VLRPYSNVSNLKVW 1618
            W ++    K+   + N +Y+ E     VL P +   N K W
Sbjct: 458  WPFLLEDQKK---YLNPLYSSESHRFTVLEPNTVSFNFKFW 495



 Score = 37.4 bits (85), Expect = 0.14
 Identities = 35/141 (24%), Positives = 60/141 (42%), Gaps = 30/141 (21%)

Query: 1113 SDRMTMSSLVERACCRDYQRLGLGTLSSSLSRAKSEPFRISPVNRMYAICRSYPGLLIVP 1172
            S+R+    L++ A   +Y+R+G+           +  +++S  NR Y IC +YP  L VP
Sbjct: 119  SERLQGWQLIDLA--EEYKRMGV----------PNSHWQLSDANRDYKICETYPRELYVP 166

Query: 1173 QSVQDNALQRVSRCYRQNRFPVVCWRSGRSKAVLLRSGGLHGKGVVGLFKAQNAPSPGQS 1232
            +      +   S+   + RFPV+ +     +A + R                + P  G S
Sbjct: 167  RIASKPIIVGSSKFRSKGRFPVLSYYHQDKEAAICRC---------------SQPLSGFS 211

Query: 1233 QADSSSLEQEKYLQAVVSSMP 1253
               +  LE E  LQA+  + P
Sbjct: 212  ---ARCLEDEHLLQAISKANP 229


>gi|221307568 DENN/MADD domain containing 4A isoform 1 [Homo
           sapiens]
          Length = 1906

 Score =  125 bits (313), Expect = 5e-28
 Identities = 109/437 (24%), Positives = 180/437 (41%), Gaps = 49/437 (11%)

Query: 27  ILQRFPEKDWEDNPFPQGIELFCQPSG-----WQLCPERNPPTFFVAVLTDINSERHYCA 81
           ++ R+P++D+E    P+ + LFC P G     W    +   P F   VLT  ++E+ Y A
Sbjct: 212 LICRYPQEDYESFSLPESVPLFCLPMGATIECWPSNSKYPLPVFSTFVLTGASAEKVYGA 271

Query: 82  CLTFWEPAEPSQETTRVE---DATEREEEGDEGGQTHLSPTAPAPSAQLFAPKTLVLVSR 138
            + F+EP      T +       T  + + D     H +             K + L+S 
Sbjct: 272 AIQFYEPYSEENLTEKQRLLLGLTSADGKSDSSKTIHTN-------------KCICLLSH 318

Query: 139 LDHTEVFRNSLGLIYAIHVEGLNVC-LENVIGNLL-TCTVPLAGGSQRTISLGAGDRQVI 196
               + FR  L  +Y   + G +V  +E  I + +     P     +  + L   D  ++
Sbjct: 319 WPFFDAFRKFLTFLYRYSISGPHVLPIEKHISHFMHKVPFPSPQRPRILVQLSPHDNLIL 378

Query: 197 QTPLADSLPVSRCSVALLFRQLGITNVLSLFCAALTEHKVLFLSRSYQRLADACRGLLAL 256
             P++  LP+S    + L + LG  N ++L   A+TEHK+L  S     L      L+++
Sbjct: 379 SQPVSSPLPLSGGKFSTLLQNLGPENAVTLLVFAVTEHKILIHSLRPSVLTSVTEALVSM 438

Query: 257 LFPLRYSFTYVPILPAQLLEVLSTPTPFIIGVNAAFQAETQELLDVIVADLDGGTVT--- 313
           +FP  +   YVP+ P  L +VLS P PFI+G+++ +        DV   D+D  T++   
Sbjct: 439 IFPFHWPCPYVPLCPLALADVLSAPCPFIVGIDSRYFDLYDPPPDVSCVDVDTNTISQIG 498

Query: 314 ---------IPE--CVHIPPLPEPLQSQTHSVLSMVLDP---ELELADLAFPPPTTSTSS 359
                    +P+  C ++      L  Q   +     D    +L + D  F     S   
Sbjct: 499 DKKNVAWKILPKKPCKNLMNTLNNLHQQLAKLQQRPRDDGLMDLAINDYDF----NSGKR 554

Query: 360 LKMQDKELRAVFLRLFAQLLQGYRWCLHVVRIHP-----EPVIRFHKAAFLGQRGLVEDD 414
           L M D E++  FL   A +L+GYR  L  +   P     +    F   AFL  R      
Sbjct: 555 LHMIDLEIQEAFLFFMASILKGYRSYLRPITQAPSETATDAASLFALQAFLRSRDRSHQK 614

Query: 415 FLMKVLEGMAFAGFVSE 431
           F   + +   F  F+ E
Sbjct: 615 FYNMMTKTQMFIRFIEE 631


>gi|221307566 DENN/MADD domain containing 4A isoform 2 [Homo
           sapiens]
          Length = 1863

 Score =  125 bits (313), Expect = 5e-28
 Identities = 109/437 (24%), Positives = 180/437 (41%), Gaps = 49/437 (11%)

Query: 27  ILQRFPEKDWEDNPFPQGIELFCQPSG-----WQLCPERNPPTFFVAVLTDINSERHYCA 81
           ++ R+P++D+E    P+ + LFC P G     W    +   P F   VLT  ++E+ Y A
Sbjct: 212 LICRYPQEDYESFSLPESVPLFCLPMGATIECWPSNSKYPLPVFSTFVLTGASAEKVYGA 271

Query: 82  CLTFWEPAEPSQETTRVE---DATEREEEGDEGGQTHLSPTAPAPSAQLFAPKTLVLVSR 138
            + F+EP      T +       T  + + D     H +             K + L+S 
Sbjct: 272 AIQFYEPYSEENLTEKQRLLLGLTSADGKSDSSKTIHTN-------------KCICLLSH 318

Query: 139 LDHTEVFRNSLGLIYAIHVEGLNVC-LENVIGNLL-TCTVPLAGGSQRTISLGAGDRQVI 196
               + FR  L  +Y   + G +V  +E  I + +     P     +  + L   D  ++
Sbjct: 319 WPFFDAFRKFLTFLYRYSISGPHVLPIEKHISHFMHKVPFPSPQRPRILVQLSPHDNLIL 378

Query: 197 QTPLADSLPVSRCSVALLFRQLGITNVLSLFCAALTEHKVLFLSRSYQRLADACRGLLAL 256
             P++  LP+S    + L + LG  N ++L   A+TEHK+L  S     L      L+++
Sbjct: 379 SQPVSSPLPLSGGKFSTLLQNLGPENAVTLLVFAVTEHKILIHSLRPSVLTSVTEALVSM 438

Query: 257 LFPLRYSFTYVPILPAQLLEVLSTPTPFIIGVNAAFQAETQELLDVIVADLDGGTVT--- 313
           +FP  +   YVP+ P  L +VLS P PFI+G+++ +        DV   D+D  T++   
Sbjct: 439 IFPFHWPCPYVPLCPLALADVLSAPCPFIVGIDSRYFDLYDPPPDVSCVDVDTNTISQIG 498

Query: 314 ---------IPE--CVHIPPLPEPLQSQTHSVLSMVLDP---ELELADLAFPPPTTSTSS 359
                    +P+  C ++      L  Q   +     D    +L + D  F     S   
Sbjct: 499 DKKNVAWKILPKKPCKNLMNTLNNLHQQLAKLQQRPRDDGLMDLAINDYDF----NSGKR 554

Query: 360 LKMQDKELRAVFLRLFAQLLQGYRWCLHVVRIHP-----EPVIRFHKAAFLGQRGLVEDD 414
           L M D E++  FL   A +L+GYR  L  +   P     +    F   AFL  R      
Sbjct: 555 LHMIDLEIQEAFLFFMASILKGYRSYLRPITQAPSETATDAASLFALQAFLRSRDRSHQK 614

Query: 415 FLMKVLEGMAFAGFVSE 431
           F   + +   F  F+ E
Sbjct: 615 FYNMMTKTQMFIRFIEE 631


>gi|19923424 myotubularin related protein 9 [Homo sapiens]
          Length = 549

 Score =  118 bits (295), Expect = 6e-26
 Identities = 81/259 (31%), Positives = 126/259 (48%), Gaps = 30/259 (11%)

Query: 1371 QWELVPIEVFEARQVKASFKKLLKACVPGCPAAEPSPASFLRSLEDSEWLIQIHKLLQVS 1430
            QW  +   +     ++ S  KL++AC       +     +L  LE S WL  I ++L  +
Sbjct: 260  QWRRIHKSIERYHILQESLIKLVEACNDQTHNMD----RWLSKLEASNWLTHIKEILTTA 315

Query: 1431 VLVVELLD-SGSSVLVGLEDGWDITTQVVSLVQLLSDPFYRTLEGFRLLVEKEWLSFGHR 1489
             L  + +D  G+S+L+   +G D T QV SL Q++ +P  RT+ GF  L+E+EWL  GH 
Sbjct: 316  CLAAQCIDREGASILIHGTEGTDSTLQVTSLAQIILEPRSRTIRGFEALIEREWLQAGHP 375

Query: 1490 FSHRGAHT--LAGQSSGFTPVFLQFLDCVHQVHLQFPMEFEFSQFYLKFLGYHHVSRRFR 1547
            F  R A +     +     PVFL FLDCV Q+  QFP  FEF++ +L  L  H  + +F 
Sbjct: 376  FQQRCAQSAYCNTKQKWEAPVFLLFLDCVWQILRQFPCSFEFNENFLIMLFEHAYASQFG 435

Query: 1548 TFLLDSDYERIELGLLYEEKGERRGQVPCRSVWEYVDRLSKRTPVFHNYMYAPEDAEVLR 1607
            TFL +++ ER +L L          Q    S+W +V++ S             E ++   
Sbjct: 436  TFLGNNESERCKLKL----------QQKTMSLWSWVNQPS-------------ELSKFTN 472

Query: 1608 PYSNVSNLKVWDFYTEETL 1626
            P    +NL +W     ++L
Sbjct: 473  PLFEANNLVIWPSVAPQSL 491



 Score = 55.8 bits (133), Expect = 4e-07
 Identities = 28/68 (41%), Positives = 46/68 (67%), Gaps = 1/68 (1%)

Query: 1143 SRAKSEPFRISPVNRMYAICRSYPGLLIVPQSVQDNALQRVSRCYRQNRFPVVCWRSGRS 1202
            S A SE +R+S VN+ +A+C SYP ++ VP+S+ D AL++V+      RFPV+ +   ++
Sbjct: 137  SSATSE-WRLSYVNKEFAVCPSYPPIVTVPKSIDDEALRKVATFRHGGRFPVLSYYHKKN 195

Query: 1203 KAVLLRSG 1210
              V++RSG
Sbjct: 196  GMVIMRSG 203


>gi|124028527 myotubularin related protein 10 [Homo sapiens]
          Length = 777

 Score =  114 bits (284), Expect = 1e-24
 Identities = 75/223 (33%), Positives = 126/223 (56%), Gaps = 12/223 (5%)

Query: 1383 RQVKASFKKLLKACVPGCPAAEPSPASFLRSLEDSEWLIQIHKLLQVSVLVVELLDSGS- 1441
            ++V+A+F KL + CV      E +   +L SLE++ WL  +   L+ S  +V +L+S   
Sbjct: 340  QEVQAAFVKLKQLCVN--EPFEETEEKWLSSLENTRWLEYVRAFLKHSAELVYMLESKHL 397

Query: 1442 SVLVGLEDGWDITTQVVSLVQLLSDPFYRTLEGFRLLVEKEWLSFGHRFSHRGAHTLAGQ 1501
            SV++  E+G D++  V SLVQ++ DP++RT+ GF+ L++KEW+  G++F  R  H    +
Sbjct: 398  SVVLQEEEGRDLSCCVASLVQVMLDPYFRTITGFQSLIQKEWVMAGYQFLDRCNHLKRSE 457

Query: 1502 SSGFTPVFLQFLDCVHQVHLQFPMEFEFSQFYLKFLGYHHVSRRFRTFLLDSDYERIELG 1561
                +P+FL FLD   Q+  Q+P  FEFS+ YL  L        F TFL +S ++R++  
Sbjct: 458  KE--SPLFLLFLDATWQLLEQYPAAFEFSETYLAVLYDSTRISLFGTFLFNSPHQRVKQS 515

Query: 1562 LLYE-----EKGERRGQVPCRSVWEY-VDRLSKRTPVFHNYMY 1598
              +      + G+ +G +   SVW++ +   +K   +FHN  Y
Sbjct: 516  TEFAISKNIQLGDEKG-LKFPSVWDWSLQFTAKDRTLFHNPFY 557



 Score = 38.1 bits (87), Expect = 0.082
 Identities = 17/65 (26%), Positives = 30/65 (46%)

Query: 1142 LSRAKSEPFRISPVNRMYAICRSYPGLLIVPQSVQDNALQRVSRCYRQNRFPVVCWRSGR 1201
            + R  +  +R+  +N  Y I    P  ++VP S+ D  L+  S  +   R P+ CW    
Sbjct: 231  IKRTGASGWRVCSINEGYMISTCLPEYIVVPSSLADQDLKIFSHSFVGRRMPLWCWSHSN 290

Query: 1202 SKAVL 1206
              A++
Sbjct: 291  GSALV 295


>gi|44889475 RAB6 interacting protein 1 [Homo sapiens]
          Length = 1287

 Score =  105 bits (261), Expect = 5e-22
 Identities = 88/343 (25%), Positives = 148/343 (43%), Gaps = 48/343 (13%)

Query: 24  QGQILQRFPEK-DWEDNPFPQ-GIELFCQPSGWQLCPERNP--PTFFVAVLTDINSERHY 79
           + ++L R+PE  +W  NPF Q  + + C P G     + +P  P F   ++T  +  R +
Sbjct: 74  KSKVLARYPENVEW--NPFDQDAVGMLCMPKGLAFKTQADPREPQFHAFIITREDGSRTF 131

Query: 80  CACLTFWEPAEPSQ----------------ETTRVEDATEREEEGDEGGQTHLSPTAPAP 123
              LTF+E     Q                +      A +R++   E G+       P  
Sbjct: 132 GFALTFYEEVTSKQICSAMQTLYHMHNAEYDVLHAPPADDRDQSSMEDGED-----TPVT 186

Query: 124 SAQ-----------LFAPKTLVLVSRLDHTEVFRNSLGLIY--AIHVEGLNVCLENVIGN 170
             Q           L+  K + L++ +   +  R+ L  ++      +   + LE+ I N
Sbjct: 187 KLQRFNSYDISRDTLYVSKCICLITPMSFMKACRSVLEQLHQAVTSPQPPPLPLESYIYN 246

Query: 171 LLTCTVPLAGGSQRTISLGAGDRQVIQTPLADSLPVSRCSVALLFRQLGITNVLSLFCAA 230
           +L   VPL    +     G     + Q P  + LP+    V  +F  LG+ NV  LF  A
Sbjct: 247 VLY-EVPLPPPGRSLKFSGVYGPIICQRPSTNELPLFDFPVKEVFELLGVENVFQLFTCA 305

Query: 231 LTEHKVLFLSRSYQRLADACRGLLALLFPLRYSFTYVPILPAQLLEVLSTPTPFIIGVNA 290
           L E ++L  S+ YQRL      + AL+FP ++   YVPILPA LL  L  P P+++G+++
Sbjct: 306 LLEFQILLYSQHYQRLMTVAETITALMFPFQWQHVYVPILPASLLHFLDAPVPYLMGLHS 365

Query: 291 -----AFQAETQELLDVIVADLDGGTVTIPECVHIPPLPEPLQ 328
                  + E  +  ++   D+D   + +PE   +P  P  L+
Sbjct: 366 NGLDDRSKLELPQEANLCFVDIDNHFIELPE--DLPQFPNKLE 406


>gi|209863002 MAP-kinase activating death domain-containing protein
           isoform j [Homo sapiens]
          Length = 1541

 Score =  103 bits (257), Expect = 2e-21
 Identities = 133/528 (25%), Positives = 200/528 (37%), Gaps = 127/528 (24%)

Query: 3   RLADYFVLVAFGPHPRGSGEGQG-QILQRFPEKDWEDNPFPQGIELFCQPSGWQLCPER- 60
           RL DY V+V    HP      Q  ++L+R+P +D  + P P  +  FCQP G     +R 
Sbjct: 10  RLLDYLVIVG-ARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEGCLSVRQRR 68

Query: 61  ---NPPTFFVAVLTDINS-ERHYCACLTFWEPAEP--------------SQETTRV---- 98
                 T FV  LTD ++    Y  C+ F+   +                +E T      
Sbjct: 69  MSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKEGTHATCAS 128

Query: 99  -EDATEREEEG--------DEGGQTHLSPTAP--APSAQLFAPKTLVLVSRLDHTEVFRN 147
            E  TE  E G        D     + SP     A +       TL  +  L H   F  
Sbjct: 129 EEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVLSHYPFFST 188

Query: 148 SLGLIYAIHVEGLNVCLENVIG-------------------------------------- 169
               +Y +    ++ C E ++G                                      
Sbjct: 189 FRECLYTLK-RLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSALLHDLREI 247

Query: 170 -----NLLTCTVPLAGGSQRTISLGAGDRQVIQTPLADSLP-VSRCSVA-----LLFRQL 218
                 LL   VP++G  +  I +     Q +Q  L  +LP  SR ++      L    L
Sbjct: 248 EAWIYRLLRSPVPVSGQKRVDIEVLP---QELQPALTFALPDPSRFTLVDFPLHLPLELL 304

Query: 219 GITNVLSLFCAALTEHKVLFLSRSYQRLADACRGLLALLFPLRYSFTYVPILP---AQLL 275
           G+   L +    L EHKV+  SR Y  L+ +    +A+++PL Y F  +P+LP   A   
Sbjct: 305 GVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAE 364

Query: 276 EVLSTPTPFIIGVNAAF---QAETQELLDVIVADLDGGTVTIP---ECVHIPPLPEPLQS 329
           ++L  PTP+IIGV A+F   + + +   DV + DLD   V  P   E + I P PE L+ 
Sbjct: 365 QLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPESLEL 424

Query: 330 QTH-----SVLSMVLDPELELA-----------------DLAFPP-----PTTSTSSLKM 362
           + H     + +S+   P L L                  DL   P     P    + +  
Sbjct: 425 KKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGNDVDS 484

Query: 363 QDKELRAVFLRLF--AQLLQGYRWCLHVVRIHPEPVIRFHKAAFLGQR 408
            D   R   +R F  A +LQG++     +R+ P PV+ F   +FL  R
Sbjct: 485 VDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASR 532


>gi|209862998 MAP-kinase activating death domain-containing protein
           isoform i [Homo sapiens]
          Length = 1544

 Score =  103 bits (257), Expect = 2e-21
 Identities = 133/528 (25%), Positives = 200/528 (37%), Gaps = 127/528 (24%)

Query: 3   RLADYFVLVAFGPHPRGSGEGQG-QILQRFPEKDWEDNPFPQGIELFCQPSGWQLCPER- 60
           RL DY V+V    HP      Q  ++L+R+P +D  + P P  +  FCQP G     +R 
Sbjct: 10  RLLDYLVIVG-ARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEGCLSVRQRR 68

Query: 61  ---NPPTFFVAVLTDINS-ERHYCACLTFWEPAEP--------------SQETTRV---- 98
                 T FV  LTD ++    Y  C+ F+   +                +E T      
Sbjct: 69  MSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKEGTHATCAS 128

Query: 99  -EDATEREEEG--------DEGGQTHLSPTAP--APSAQLFAPKTLVLVSRLDHTEVFRN 147
            E  TE  E G        D     + SP     A +       TL  +  L H   F  
Sbjct: 129 EEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVLSHYPFFST 188

Query: 148 SLGLIYAIHVEGLNVCLENVIG-------------------------------------- 169
               +Y +    ++ C E ++G                                      
Sbjct: 189 FRECLYTLK-RLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSALLHDLREI 247

Query: 170 -----NLLTCTVPLAGGSQRTISLGAGDRQVIQTPLADSLP-VSRCSVA-----LLFRQL 218
                 LL   VP++G  +  I +     Q +Q  L  +LP  SR ++      L    L
Sbjct: 248 EAWIYRLLRSPVPVSGQKRVDIEVLP---QELQPALTFALPDPSRFTLVDFPLHLPLELL 304

Query: 219 GITNVLSLFCAALTEHKVLFLSRSYQRLADACRGLLALLFPLRYSFTYVPILP---AQLL 275
           G+   L +    L EHKV+  SR Y  L+ +    +A+++PL Y F  +P+LP   A   
Sbjct: 305 GVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAE 364

Query: 276 EVLSTPTPFIIGVNAAF---QAETQELLDVIVADLDGGTVTIP---ECVHIPPLPEPLQS 329
           ++L  PTP+IIGV A+F   + + +   DV + DLD   V  P   E + I P PE L+ 
Sbjct: 365 QLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPESLEL 424

Query: 330 QTH-----SVLSMVLDPELELA-----------------DLAFPP-----PTTSTSSLKM 362
           + H     + +S+   P L L                  DL   P     P    + +  
Sbjct: 425 KKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGNDVDS 484

Query: 363 QDKELRAVFLRLF--AQLLQGYRWCLHVVRIHPEPVIRFHKAAFLGQR 408
            D   R   +R F  A +LQG++     +R+ P PV+ F   +FL  R
Sbjct: 485 VDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASR 532


>gi|209862994 MAP-kinase activating death domain-containing protein
           isoform d [Homo sapiens]
          Length = 1647

 Score =  103 bits (257), Expect = 2e-21
 Identities = 133/528 (25%), Positives = 200/528 (37%), Gaps = 127/528 (24%)

Query: 3   RLADYFVLVAFGPHPRGSGEGQG-QILQRFPEKDWEDNPFPQGIELFCQPSGWQLCPER- 60
           RL DY V+V    HP      Q  ++L+R+P +D  + P P  +  FCQP G     +R 
Sbjct: 10  RLLDYLVIVG-ARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEGCLSVRQRR 68

Query: 61  ---NPPTFFVAVLTDINS-ERHYCACLTFWEPAEP--------------SQETTRV---- 98
                 T FV  LTD ++    Y  C+ F+   +                +E T      
Sbjct: 69  MSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKEGTHATCAS 128

Query: 99  -EDATEREEEG--------DEGGQTHLSPTAP--APSAQLFAPKTLVLVSRLDHTEVFRN 147
            E  TE  E G        D     + SP     A +       TL  +  L H   F  
Sbjct: 129 EEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVLSHYPFFST 188

Query: 148 SLGLIYAIHVEGLNVCLENVIG-------------------------------------- 169
               +Y +    ++ C E ++G                                      
Sbjct: 189 FRECLYTLK-RLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSALLHDLREI 247

Query: 170 -----NLLTCTVPLAGGSQRTISLGAGDRQVIQTPLADSLP-VSRCSVA-----LLFRQL 218
                 LL   VP++G  +  I +     Q +Q  L  +LP  SR ++      L    L
Sbjct: 248 EAWIYRLLRSPVPVSGQKRVDIEVLP---QELQPALTFALPDPSRFTLVDFPLHLPLELL 304

Query: 219 GITNVLSLFCAALTEHKVLFLSRSYQRLADACRGLLALLFPLRYSFTYVPILP---AQLL 275
           G+   L +    L EHKV+  SR Y  L+ +    +A+++PL Y F  +P+LP   A   
Sbjct: 305 GVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAE 364

Query: 276 EVLSTPTPFIIGVNAAF---QAETQELLDVIVADLDGGTVTIP---ECVHIPPLPEPLQS 329
           ++L  PTP+IIGV A+F   + + +   DV + DLD   V  P   E + I P PE L+ 
Sbjct: 365 QLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPESLEL 424

Query: 330 QTH-----SVLSMVLDPELELA-----------------DLAFPP-----PTTSTSSLKM 362
           + H     + +S+   P L L                  DL   P     P    + +  
Sbjct: 425 KKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGNDVDS 484

Query: 363 QDKELRAVFLRLF--AQLLQGYRWCLHVVRIHPEPVIRFHKAAFLGQR 408
            D   R   +R F  A +LQG++     +R+ P PV+ F   +FL  R
Sbjct: 485 VDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASR 532


>gi|18860873 MAP-kinase activating death domain-containing protein
           isoform g [Homo sapiens]
          Length = 1581

 Score =  103 bits (257), Expect = 2e-21
 Identities = 133/528 (25%), Positives = 200/528 (37%), Gaps = 127/528 (24%)

Query: 3   RLADYFVLVAFGPHPRGSGEGQG-QILQRFPEKDWEDNPFPQGIELFCQPSGWQLCPER- 60
           RL DY V+V    HP      Q  ++L+R+P +D  + P P  +  FCQP G     +R 
Sbjct: 10  RLLDYLVIVG-ARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEGCLSVRQRR 68

Query: 61  ---NPPTFFVAVLTDINS-ERHYCACLTFWEPAEP--------------SQETTRV---- 98
                 T FV  LTD ++    Y  C+ F+   +                +E T      
Sbjct: 69  MSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKEGTHATCAS 128

Query: 99  -EDATEREEEG--------DEGGQTHLSPTAP--APSAQLFAPKTLVLVSRLDHTEVFRN 147
            E  TE  E G        D     + SP     A +       TL  +  L H   F  
Sbjct: 129 EEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVLSHYPFFST 188

Query: 148 SLGLIYAIHVEGLNVCLENVIG-------------------------------------- 169
               +Y +    ++ C E ++G                                      
Sbjct: 189 FRECLYTLK-RLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSALLHDLREI 247

Query: 170 -----NLLTCTVPLAGGSQRTISLGAGDRQVIQTPLADSLP-VSRCSVA-----LLFRQL 218
                 LL   VP++G  +  I +     Q +Q  L  +LP  SR ++      L    L
Sbjct: 248 EAWIYRLLRSPVPVSGQKRVDIEVLP---QELQPALTFALPDPSRFTLVDFPLHLPLELL 304

Query: 219 GITNVLSLFCAALTEHKVLFLSRSYQRLADACRGLLALLFPLRYSFTYVPILP---AQLL 275
           G+   L +    L EHKV+  SR Y  L+ +    +A+++PL Y F  +P+LP   A   
Sbjct: 305 GVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAE 364

Query: 276 EVLSTPTPFIIGVNAAF---QAETQELLDVIVADLDGGTVTIP---ECVHIPPLPEPLQS 329
           ++L  PTP+IIGV A+F   + + +   DV + DLD   V  P   E + I P PE L+ 
Sbjct: 365 QLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPESLEL 424

Query: 330 QTH-----SVLSMVLDPELELA-----------------DLAFPP-----PTTSTSSLKM 362
           + H     + +S+   P L L                  DL   P     P    + +  
Sbjct: 425 KKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGNDVDS 484

Query: 363 QDKELRAVFLRLF--AQLLQGYRWCLHVVRIHPEPVIRFHKAAFLGQR 408
            D   R   +R F  A +LQG++     +R+ P PV+ F   +FL  R
Sbjct: 485 VDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASR 532


>gi|209862987 MAP-kinase activating death domain-containing protein
           isoform f [Homo sapiens]
          Length = 1479

 Score =  103 bits (257), Expect = 2e-21
 Identities = 133/528 (25%), Positives = 200/528 (37%), Gaps = 127/528 (24%)

Query: 3   RLADYFVLVAFGPHPRGSGEGQG-QILQRFPEKDWEDNPFPQGIELFCQPSGWQLCPER- 60
           RL DY V+V    HP      Q  ++L+R+P +D  + P P  +  FCQP G     +R 
Sbjct: 10  RLLDYLVIVG-ARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEGCLSVRQRR 68

Query: 61  ---NPPTFFVAVLTDINS-ERHYCACLTFWEPAEP--------------SQETTRV---- 98
                 T FV  LTD ++    Y  C+ F+   +                +E T      
Sbjct: 69  MSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKEGTHATCAS 128

Query: 99  -EDATEREEEG--------DEGGQTHLSPTAP--APSAQLFAPKTLVLVSRLDHTEVFRN 147
            E  TE  E G        D     + SP     A +       TL  +  L H   F  
Sbjct: 129 EEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVLSHYPFFST 188

Query: 148 SLGLIYAIHVEGLNVCLENVIG-------------------------------------- 169
               +Y +    ++ C E ++G                                      
Sbjct: 189 FRECLYTLK-RLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSALLHDLREI 247

Query: 170 -----NLLTCTVPLAGGSQRTISLGAGDRQVIQTPLADSLP-VSRCSVA-----LLFRQL 218
                 LL   VP++G  +  I +     Q +Q  L  +LP  SR ++      L    L
Sbjct: 248 EAWIYRLLRSPVPVSGQKRVDIEVLP---QELQPALTFALPDPSRFTLVDFPLHLPLELL 304

Query: 219 GITNVLSLFCAALTEHKVLFLSRSYQRLADACRGLLALLFPLRYSFTYVPILP---AQLL 275
           G+   L +    L EHKV+  SR Y  L+ +    +A+++PL Y F  +P+LP   A   
Sbjct: 305 GVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAE 364

Query: 276 EVLSTPTPFIIGVNAAF---QAETQELLDVIVADLDGGTVTIP---ECVHIPPLPEPLQS 329
           ++L  PTP+IIGV A+F   + + +   DV + DLD   V  P   E + I P PE L+ 
Sbjct: 365 QLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPESLEL 424

Query: 330 QTH-----SVLSMVLDPELELA-----------------DLAFPP-----PTTSTSSLKM 362
           + H     + +S+   P L L                  DL   P     P    + +  
Sbjct: 425 KKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGNDVDS 484

Query: 363 QDKELRAVFLRLF--AQLLQGYRWCLHVVRIHPEPVIRFHKAAFLGQR 408
            D   R   +R F  A +LQG++     +R+ P PV+ F   +FL  R
Sbjct: 485 VDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASR 532


>gi|209862983 MAP-kinase activating death domain-containing protein
           isoform e [Homo sapiens]
          Length = 1608

 Score =  103 bits (257), Expect = 2e-21
 Identities = 133/528 (25%), Positives = 200/528 (37%), Gaps = 127/528 (24%)

Query: 3   RLADYFVLVAFGPHPRGSGEGQG-QILQRFPEKDWEDNPFPQGIELFCQPSGWQLCPER- 60
           RL DY V+V    HP      Q  ++L+R+P +D  + P P  +  FCQP G     +R 
Sbjct: 10  RLLDYLVIVG-ARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEGCLSVRQRR 68

Query: 61  ---NPPTFFVAVLTDINS-ERHYCACLTFWEPAEP--------------SQETTRV---- 98
                 T FV  LTD ++    Y  C+ F+   +                +E T      
Sbjct: 69  MSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKEGTHATCAS 128

Query: 99  -EDATEREEEG--------DEGGQTHLSPTAP--APSAQLFAPKTLVLVSRLDHTEVFRN 147
            E  TE  E G        D     + SP     A +       TL  +  L H   F  
Sbjct: 129 EEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVLSHYPFFST 188

Query: 148 SLGLIYAIHVEGLNVCLENVIG-------------------------------------- 169
               +Y +    ++ C E ++G                                      
Sbjct: 189 FRECLYTLK-RLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSALLHDLREI 247

Query: 170 -----NLLTCTVPLAGGSQRTISLGAGDRQVIQTPLADSLP-VSRCSVA-----LLFRQL 218
                 LL   VP++G  +  I +     Q +Q  L  +LP  SR ++      L    L
Sbjct: 248 EAWIYRLLRSPVPVSGQKRVDIEVLP---QELQPALTFALPDPSRFTLVDFPLHLPLELL 304

Query: 219 GITNVLSLFCAALTEHKVLFLSRSYQRLADACRGLLALLFPLRYSFTYVPILP---AQLL 275
           G+   L +    L EHKV+  SR Y  L+ +    +A+++PL Y F  +P+LP   A   
Sbjct: 305 GVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAE 364

Query: 276 EVLSTPTPFIIGVNAAF---QAETQELLDVIVADLDGGTVTIP---ECVHIPPLPEPLQS 329
           ++L  PTP+IIGV A+F   + + +   DV + DLD   V  P   E + I P PE L+ 
Sbjct: 365 QLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPESLEL 424

Query: 330 QTH-----SVLSMVLDPELELA-----------------DLAFPP-----PTTSTSSLKM 362
           + H     + +S+   P L L                  DL   P     P    + +  
Sbjct: 425 KKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGNDVDS 484

Query: 363 QDKELRAVFLRLF--AQLLQGYRWCLHVVRIHPEPVIRFHKAAFLGQR 408
            D   R   +R F  A +LQG++     +R+ P PV+ F   +FL  R
Sbjct: 485 VDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASR 532


>gi|209862979 MAP-kinase activating death domain-containing protein
           isoform c [Homo sapiens]
          Length = 1545

 Score =  103 bits (257), Expect = 2e-21
 Identities = 133/528 (25%), Positives = 200/528 (37%), Gaps = 127/528 (24%)

Query: 3   RLADYFVLVAFGPHPRGSGEGQG-QILQRFPEKDWEDNPFPQGIELFCQPSGWQLCPER- 60
           RL DY V+V    HP      Q  ++L+R+P +D  + P P  +  FCQP G     +R 
Sbjct: 10  RLLDYLVIVG-ARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEGCLSVRQRR 68

Query: 61  ---NPPTFFVAVLTDINS-ERHYCACLTFWEPAEP--------------SQETTRV---- 98
                 T FV  LTD ++    Y  C+ F+   +                +E T      
Sbjct: 69  MSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKEGTHATCAS 128

Query: 99  -EDATEREEEG--------DEGGQTHLSPTAP--APSAQLFAPKTLVLVSRLDHTEVFRN 147
            E  TE  E G        D     + SP     A +       TL  +  L H   F  
Sbjct: 129 EEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVLSHYPFFST 188

Query: 148 SLGLIYAIHVEGLNVCLENVIG-------------------------------------- 169
               +Y +    ++ C E ++G                                      
Sbjct: 189 FRECLYTLK-RLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSALLHDLREI 247

Query: 170 -----NLLTCTVPLAGGSQRTISLGAGDRQVIQTPLADSLP-VSRCSVA-----LLFRQL 218
                 LL   VP++G  +  I +     Q +Q  L  +LP  SR ++      L    L
Sbjct: 248 EAWIYRLLRSPVPVSGQKRVDIEVLP---QELQPALTFALPDPSRFTLVDFPLHLPLELL 304

Query: 219 GITNVLSLFCAALTEHKVLFLSRSYQRLADACRGLLALLFPLRYSFTYVPILP---AQLL 275
           G+   L +    L EHKV+  SR Y  L+ +    +A+++PL Y F  +P+LP   A   
Sbjct: 305 GVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAE 364

Query: 276 EVLSTPTPFIIGVNAAF---QAETQELLDVIVADLDGGTVTIP---ECVHIPPLPEPLQS 329
           ++L  PTP+IIGV A+F   + + +   DV + DLD   V  P   E + I P PE L+ 
Sbjct: 365 QLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPESLEL 424

Query: 330 QTH-----SVLSMVLDPELELA-----------------DLAFPP-----PTTSTSSLKM 362
           + H     + +S+   P L L                  DL   P     P    + +  
Sbjct: 425 KKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGNDVDS 484

Query: 363 QDKELRAVFLRLF--AQLLQGYRWCLHVVRIHPEPVIRFHKAAFLGQR 408
            D   R   +R F  A +LQG++     +R+ P PV+ F   +FL  R
Sbjct: 485 VDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASR 532


>gi|209862975 MAP-kinase activating death domain-containing protein
           isoform b [Homo sapiens]
          Length = 1565

 Score =  103 bits (257), Expect = 2e-21
 Identities = 133/528 (25%), Positives = 200/528 (37%), Gaps = 127/528 (24%)

Query: 3   RLADYFVLVAFGPHPRGSGEGQG-QILQRFPEKDWEDNPFPQGIELFCQPSGWQLCPER- 60
           RL DY V+V    HP      Q  ++L+R+P +D  + P P  +  FCQP G     +R 
Sbjct: 10  RLLDYLVIVG-ARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEGCLSVRQRR 68

Query: 61  ---NPPTFFVAVLTDINS-ERHYCACLTFWEPAEP--------------SQETTRV---- 98
                 T FV  LTD ++    Y  C+ F+   +                +E T      
Sbjct: 69  MSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKEGTHATCAS 128

Query: 99  -EDATEREEEG--------DEGGQTHLSPTAP--APSAQLFAPKTLVLVSRLDHTEVFRN 147
            E  TE  E G        D     + SP     A +       TL  +  L H   F  
Sbjct: 129 EEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVLSHYPFFST 188

Query: 148 SLGLIYAIHVEGLNVCLENVIG-------------------------------------- 169
               +Y +    ++ C E ++G                                      
Sbjct: 189 FRECLYTLK-RLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSALLHDLREI 247

Query: 170 -----NLLTCTVPLAGGSQRTISLGAGDRQVIQTPLADSLP-VSRCSVA-----LLFRQL 218
                 LL   VP++G  +  I +     Q +Q  L  +LP  SR ++      L    L
Sbjct: 248 EAWIYRLLRSPVPVSGQKRVDIEVLP---QELQPALTFALPDPSRFTLVDFPLHLPLELL 304

Query: 219 GITNVLSLFCAALTEHKVLFLSRSYQRLADACRGLLALLFPLRYSFTYVPILP---AQLL 275
           G+   L +    L EHKV+  SR Y  L+ +    +A+++PL Y F  +P+LP   A   
Sbjct: 305 GVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAE 364

Query: 276 EVLSTPTPFIIGVNAAF---QAETQELLDVIVADLDGGTVTIP---ECVHIPPLPEPLQS 329
           ++L  PTP+IIGV A+F   + + +   DV + DLD   V  P   E + I P PE L+ 
Sbjct: 365 QLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPESLEL 424

Query: 330 QTH-----SVLSMVLDPELELA-----------------DLAFPP-----PTTSTSSLKM 362
           + H     + +S+   P L L                  DL   P     P    + +  
Sbjct: 425 KKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGNDVDS 484

Query: 363 QDKELRAVFLRLF--AQLLQGYRWCLHVVRIHPEPVIRFHKAAFLGQR 408
            D   R   +R F  A +LQG++     +R+ P PV+ F   +FL  R
Sbjct: 485 VDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASR 532


>gi|209862971 MAP-kinase activating death domain-containing protein
           isoform a [Homo sapiens]
          Length = 1588

 Score =  103 bits (257), Expect = 2e-21
 Identities = 133/528 (25%), Positives = 200/528 (37%), Gaps = 127/528 (24%)

Query: 3   RLADYFVLVAFGPHPRGSGEGQG-QILQRFPEKDWEDNPFPQGIELFCQPSGWQLCPER- 60
           RL DY V+V    HP      Q  ++L+R+P +D  + P P  +  FCQP G     +R 
Sbjct: 10  RLLDYLVIVG-ARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEGCLSVRQRR 68

Query: 61  ---NPPTFFVAVLTDINS-ERHYCACLTFWEPAEP--------------SQETTRV---- 98
                 T FV  LTD ++    Y  C+ F+   +                +E T      
Sbjct: 69  MSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKEGTHATCAS 128

Query: 99  -EDATEREEEG--------DEGGQTHLSPTAP--APSAQLFAPKTLVLVSRLDHTEVFRN 147
            E  TE  E G        D     + SP     A +       TL  +  L H   F  
Sbjct: 129 EEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVLSHYPFFST 188

Query: 148 SLGLIYAIHVEGLNVCLENVIG-------------------------------------- 169
               +Y +    ++ C E ++G                                      
Sbjct: 189 FRECLYTLK-RLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSALLHDLREI 247

Query: 170 -----NLLTCTVPLAGGSQRTISLGAGDRQVIQTPLADSLP-VSRCSVA-----LLFRQL 218
                 LL   VP++G  +  I +     Q +Q  L  +LP  SR ++      L    L
Sbjct: 248 EAWIYRLLRSPVPVSGQKRVDIEVLP---QELQPALTFALPDPSRFTLVDFPLHLPLELL 304

Query: 219 GITNVLSLFCAALTEHKVLFLSRSYQRLADACRGLLALLFPLRYSFTYVPILP---AQLL 275
           G+   L +    L EHKV+  SR Y  L+ +    +A+++PL Y F  +P+LP   A   
Sbjct: 305 GVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAE 364

Query: 276 EVLSTPTPFIIGVNAAF---QAETQELLDVIVADLDGGTVTIP---ECVHIPPLPEPLQS 329
           ++L  PTP+IIGV A+F   + + +   DV + DLD   V  P   E + I P PE L+ 
Sbjct: 365 QLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPESLEL 424

Query: 330 QTH-----SVLSMVLDPELELA-----------------DLAFPP-----PTTSTSSLKM 362
           + H     + +S+   P L L                  DL   P     P    + +  
Sbjct: 425 KKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGNDVDS 484

Query: 363 QDKELRAVFLRLF--AQLLQGYRWCLHVVRIHPEPVIRFHKAAFLGQR 408
            D   R   +R F  A +LQG++     +R+ P PV+ F   +FL  R
Sbjct: 485 VDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASR 532


>gi|209571517 MAP-kinase activating death domain-containing protein
           isoform h [Homo sapiens]
          Length = 1587

 Score =  103 bits (257), Expect = 2e-21
 Identities = 133/528 (25%), Positives = 200/528 (37%), Gaps = 127/528 (24%)

Query: 3   RLADYFVLVAFGPHPRGSGEGQG-QILQRFPEKDWEDNPFPQGIELFCQPSGWQLCPER- 60
           RL DY V+V    HP      Q  ++L+R+P +D  + P P  +  FCQP G     +R 
Sbjct: 10  RLLDYLVIVG-ARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEGCLSVRQRR 68

Query: 61  ---NPPTFFVAVLTDINS-ERHYCACLTFWEPAEP--------------SQETTRV---- 98
                 T FV  LTD ++    Y  C+ F+   +                +E T      
Sbjct: 69  MSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKEGTHATCAS 128

Query: 99  -EDATEREEEG--------DEGGQTHLSPTAP--APSAQLFAPKTLVLVSRLDHTEVFRN 147
            E  TE  E G        D     + SP     A +       TL  +  L H   F  
Sbjct: 129 EEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVLSHYPFFST 188

Query: 148 SLGLIYAIHVEGLNVCLENVIG-------------------------------------- 169
               +Y +    ++ C E ++G                                      
Sbjct: 189 FRECLYTLK-RLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSALLHDLREI 247

Query: 170 -----NLLTCTVPLAGGSQRTISLGAGDRQVIQTPLADSLP-VSRCSVA-----LLFRQL 218
                 LL   VP++G  +  I +     Q +Q  L  +LP  SR ++      L    L
Sbjct: 248 EAWIYRLLRSPVPVSGQKRVDIEVLP---QELQPALTFALPDPSRFTLVDFPLHLPLELL 304

Query: 219 GITNVLSLFCAALTEHKVLFLSRSYQRLADACRGLLALLFPLRYSFTYVPILP---AQLL 275
           G+   L +    L EHKV+  SR Y  L+ +    +A+++PL Y F  +P+LP   A   
Sbjct: 305 GVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAE 364

Query: 276 EVLSTPTPFIIGVNAAF---QAETQELLDVIVADLDGGTVTIP---ECVHIPPLPEPLQS 329
           ++L  PTP+IIGV A+F   + + +   DV + DLD   V  P   E + I P PE L+ 
Sbjct: 365 QLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPESLEL 424

Query: 330 QTH-----SVLSMVLDPELELA-----------------DLAFPP-----PTTSTSSLKM 362
           + H     + +S+   P L L                  DL   P     P    + +  
Sbjct: 425 KKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGNDVDS 484

Query: 363 QDKELRAVFLRLF--AQLLQGYRWCLHVVRIHPEPVIRFHKAAFLGQR 408
            D   R   +R F  A +LQG++     +R+ P PV+ F   +FL  R
Sbjct: 485 VDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASR 532


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.134    0.405 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 79,589,511
Number of Sequences: 37866
Number of extensions: 4037921
Number of successful extensions: 14348
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 64
Number of HSP's successfully gapped in prelim test: 79
Number of HSP's that attempted gapping in prelim test: 13999
Number of HSP's gapped (non-prelim): 312
length of query: 1893
length of database: 18,247,518
effective HSP length: 117
effective length of query: 1776
effective length of database: 13,817,196
effective search space: 24539340096
effective search space used: 24539340096
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 70 (31.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.