Guide to the Human Genome
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Search of human proteins with 239508992

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|239508992 PREDICTED: similar to calcium-promoted Ras
inactivator isoform 1 [Homo sapiens]
         (731 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|239743309 PREDICTED: similar to calcium-promoted Ras inactiva...  1467   0.0  
gi|239508992 PREDICTED: similar to calcium-promoted Ras inactiva...  1467   0.0  
gi|121114294 RAS p21 protein activator 4 isoform 1 [Homo sapiens]    1460   0.0  
gi|239743307 PREDICTED: similar to calcium-promoted Ras inactiva...  1356   0.0  
gi|239508990 PREDICTED: similar to calcium-promoted Ras inactiva...  1356   0.0  
gi|121114292 RAS p21 protein activator 4 isoform 2 [Homo sapiens]    1348   0.0  
gi|4759026 RAS protein activator like 1 [Homo sapiens]                620   e-177
gi|12545408 RAS p21 protein activator 2 [Homo sapiens]                293   3e-79
gi|38201692 RAS p21 protein activator 3 [Homo sapiens]                283   3e-76
gi|226958575 RAS protein activator like 2 isoform 2 [Homo sapiens]    132   9e-31
gi|4758808 RAS protein activator like 2 isoform 1 [Homo sapiens]      132   9e-31
gi|41281683 disabled homolog 2 interacting protein isoform 2 [Ho...   118   2e-26
gi|94967023 disabled homolog 2 interacting protein isoform 1 [Ho...   118   2e-26
gi|194248068 synaptic Ras GTPase activating protein 1 [Homo sapi...   115   1e-25
gi|4506431 RAS p21 protein activator 1 isoform 1 [Homo sapiens]       105   1e-22
gi|12545406 RAS p21 protein activator 1 isoform 2 [Homo sapiens]      105   1e-22
gi|130502162 RAS protein activator like 3 [Homo sapiens]               87   5e-17
gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens]            84   5e-16
gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens]            84   5e-16
gi|13384594 protein kinase C, gamma [Homo sapiens]                     81   3e-15
gi|4506067 protein kinase C, alpha [Homo sapiens]                      79   1e-14
gi|4557793 neurofibromin isoform 2 [Homo sapiens]                      77   6e-14
gi|150170670 piccolo isoform 2 [Homo sapiens]                          75   3e-13
gi|150378539 piccolo isoform 1 [Homo sapiens]                          75   3e-13
gi|50582996 multiple C2 domains, transmembrane 1 isoform S [Homo...    72   2e-12
gi|205361109 multiple C2 domains, transmembrane 1 isoform L [Hom...    72   2e-12
gi|38570146 synaptotagmin VII [Homo sapiens]                           70   5e-12
gi|109826564 neurofibromin isoform 1 [Homo sapiens]                    69   2e-11
gi|47078261 double C2-like domains, alpha [Homo sapiens]               64   4e-10
gi|40068038 B/K protein [Homo sapiens]                                 64   4e-10

>gi|239743309 PREDICTED: similar to calcium-promoted Ras inactivator
           isoform 2 [Homo sapiens]
          Length = 731

 Score = 1467 bits (3799), Expect = 0.0
 Identities = 731/731 (100%), Positives = 731/731 (100%)

Query: 1   MDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEIHLRLEVWPGARA 60
           MDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEIHLRLEVWPGARA
Sbjct: 1   MDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEIHLRLEVWPGARA 60

Query: 61  CRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEGA 120
           CRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEGA
Sbjct: 61  CRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEGA 120

Query: 121 MEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGNLGSL 180
           MEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGNLGSL
Sbjct: 121 MEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGNLGSL 180

Query: 181 QLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVATNLLK 240
           QLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVATNLLK
Sbjct: 181 QLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVATNLLK 240

Query: 241 LFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSVESFLKVAGMQYLHGVLGPII 300
           LFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSVESFLKVAGMQYLHGVLGPII
Sbjct: 241 LFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSVESFLKVAGMQYLHGVLGPII 300

Query: 301 NKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSALSRSVR 360
           NKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSALSRSVR
Sbjct: 301 NKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSALSRSVR 360

Query: 361 ACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFHLRERHA 420
           ACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFHLRERHA
Sbjct: 361 ACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFHLRERHA 420

Query: 421 DARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVHQGVAQLKDFITKLVDIEEK 480
           DARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVHQGVAQLKDFITKLVDIEEK
Sbjct: 421 DARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVHQGVAQLKDFITKLVDIEEK 480

Query: 481 DELDLQRTLSLQAPPVKEGPLFIHRTKGKGPLMSSSFKKLYFSLTTEALSFAKTPSSKKS 540
           DELDLQRTLSLQAPPVKEGPLFIHRTKGKGPLMSSSFKKLYFSLTTEALSFAKTPSSKKS
Sbjct: 481 DELDLQRTLSLQAPPVKEGPLFIHRTKGKGPLMSSSFKKLYFSLTTEALSFAKTPSSKKS 540

Query: 541 ALIKLANIRAAEKVEEKSFGGSHVMQVIYTDDAGRPQTAYLQCKCVNELNQWLSALRKVS 600
           ALIKLANIRAAEKVEEKSFGGSHVMQVIYTDDAGRPQTAYLQCKCVNELNQWLSALRKVS
Sbjct: 541 ALIKLANIRAAEKVEEKSFGGSHVMQVIYTDDAGRPQTAYLQCKCVNELNQWLSALRKVS 600

Query: 601 INNTGLLGSYHPGVFRGDKWSCCHQKEKTGQGCDKTRSRVTLQEWNDPLDHDLEAQLIYR 660
           INNTGLLGSYHPGVFRGDKWSCCHQKEKTGQGCDKTRSRVTLQEWNDPLDHDLEAQLIYR
Sbjct: 601 INNTGLLGSYHPGVFRGDKWSCCHQKEKTGQGCDKTRSRVTLQEWNDPLDHDLEAQLIYR 660

Query: 661 HLLGVEAMLWERHRELSGGAEAGTVPTSPGKVPEDSLARLLRVLQDLREAHSSSPAGSPP 720
           HLLGVEAMLWERHRELSGGAEAGTVPTSPGKVPEDSLARLLRVLQDLREAHSSSPAGSPP
Sbjct: 661 HLLGVEAMLWERHRELSGGAEAGTVPTSPGKVPEDSLARLLRVLQDLREAHSSSPAGSPP 720

Query: 721 SEPNCLLELQT 731
           SEPNCLLELQT
Sbjct: 721 SEPNCLLELQT 731


>gi|239508992 PREDICTED: similar to calcium-promoted Ras inactivator
           isoform 1 [Homo sapiens]
          Length = 731

 Score = 1467 bits (3799), Expect = 0.0
 Identities = 731/731 (100%), Positives = 731/731 (100%)

Query: 1   MDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEIHLRLEVWPGARA 60
           MDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEIHLRLEVWPGARA
Sbjct: 1   MDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEIHLRLEVWPGARA 60

Query: 61  CRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEGA 120
           CRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEGA
Sbjct: 61  CRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEGA 120

Query: 121 MEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGNLGSL 180
           MEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGNLGSL
Sbjct: 121 MEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGNLGSL 180

Query: 181 QLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVATNLLK 240
           QLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVATNLLK
Sbjct: 181 QLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVATNLLK 240

Query: 241 LFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSVESFLKVAGMQYLHGVLGPII 300
           LFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSVESFLKVAGMQYLHGVLGPII
Sbjct: 241 LFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSVESFLKVAGMQYLHGVLGPII 300

Query: 301 NKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSALSRSVR 360
           NKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSALSRSVR
Sbjct: 301 NKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSALSRSVR 360

Query: 361 ACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFHLRERHA 420
           ACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFHLRERHA
Sbjct: 361 ACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFHLRERHA 420

Query: 421 DARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVHQGVAQLKDFITKLVDIEEK 480
           DARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVHQGVAQLKDFITKLVDIEEK
Sbjct: 421 DARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVHQGVAQLKDFITKLVDIEEK 480

Query: 481 DELDLQRTLSLQAPPVKEGPLFIHRTKGKGPLMSSSFKKLYFSLTTEALSFAKTPSSKKS 540
           DELDLQRTLSLQAPPVKEGPLFIHRTKGKGPLMSSSFKKLYFSLTTEALSFAKTPSSKKS
Sbjct: 481 DELDLQRTLSLQAPPVKEGPLFIHRTKGKGPLMSSSFKKLYFSLTTEALSFAKTPSSKKS 540

Query: 541 ALIKLANIRAAEKVEEKSFGGSHVMQVIYTDDAGRPQTAYLQCKCVNELNQWLSALRKVS 600
           ALIKLANIRAAEKVEEKSFGGSHVMQVIYTDDAGRPQTAYLQCKCVNELNQWLSALRKVS
Sbjct: 541 ALIKLANIRAAEKVEEKSFGGSHVMQVIYTDDAGRPQTAYLQCKCVNELNQWLSALRKVS 600

Query: 601 INNTGLLGSYHPGVFRGDKWSCCHQKEKTGQGCDKTRSRVTLQEWNDPLDHDLEAQLIYR 660
           INNTGLLGSYHPGVFRGDKWSCCHQKEKTGQGCDKTRSRVTLQEWNDPLDHDLEAQLIYR
Sbjct: 601 INNTGLLGSYHPGVFRGDKWSCCHQKEKTGQGCDKTRSRVTLQEWNDPLDHDLEAQLIYR 660

Query: 661 HLLGVEAMLWERHRELSGGAEAGTVPTSPGKVPEDSLARLLRVLQDLREAHSSSPAGSPP 720
           HLLGVEAMLWERHRELSGGAEAGTVPTSPGKVPEDSLARLLRVLQDLREAHSSSPAGSPP
Sbjct: 661 HLLGVEAMLWERHRELSGGAEAGTVPTSPGKVPEDSLARLLRVLQDLREAHSSSPAGSPP 720

Query: 721 SEPNCLLELQT 731
           SEPNCLLELQT
Sbjct: 721 SEPNCLLELQT 731


>gi|121114294 RAS p21 protein activator 4 isoform 1 [Homo sapiens]
          Length = 803

 Score = 1460 bits (3779), Expect = 0.0
 Identities = 728/731 (99%), Positives = 729/731 (99%)

Query: 1   MDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEIHLRLEVWPGARA 60
           MDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEIHLRLEVWPGARA
Sbjct: 73  MDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEIHLRLEVWPGARA 132

Query: 61  CRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEGA 120
           CRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEGA
Sbjct: 133 CRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEGA 192

Query: 121 MEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGNLGSL 180
           MEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGNLGSL
Sbjct: 193 MEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGNLGSL 252

Query: 181 QLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVATNLLK 240
           QLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVATNLLK
Sbjct: 253 QLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVATNLLK 312

Query: 241 LFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSVESFLKVAGMQYLHGVLGPII 300
           LFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKS+ESFLKVAGMQYLHGVLGPII
Sbjct: 313 LFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSMESFLKVAGMQYLHGVLGPII 372

Query: 301 NKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSALSRSVR 360
           NKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSALSRSVR
Sbjct: 373 NKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSALSRSVR 432

Query: 361 ACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFHLRERHA 420
           ACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFHLRERHA
Sbjct: 433 ACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFHLRERHA 492

Query: 421 DARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVHQGVAQLKDFITKLVDIEEK 480
           DARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTV QGVAQLKDFITKLVDIEEK
Sbjct: 493 DARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVRQGVAQLKDFITKLVDIEEK 552

Query: 481 DELDLQRTLSLQAPPVKEGPLFIHRTKGKGPLMSSSFKKLYFSLTTEALSFAKTPSSKKS 540
           DELDLQRTLSLQAPPVKEGPLFIHRTKGKGPLMSSSFKKLYFSLTTEALSFAKTPSSKKS
Sbjct: 553 DELDLQRTLSLQAPPVKEGPLFIHRTKGKGPLMSSSFKKLYFSLTTEALSFAKTPSSKKS 612

Query: 541 ALIKLANIRAAEKVEEKSFGGSHVMQVIYTDDAGRPQTAYLQCKCVNELNQWLSALRKVS 600
           ALIKLANIRAAEKVEEKSFGGSHVMQVIYTDDAGRPQTAYLQCKCVNELNQWLSALRKVS
Sbjct: 613 ALIKLANIRAAEKVEEKSFGGSHVMQVIYTDDAGRPQTAYLQCKCVNELNQWLSALRKVS 672

Query: 601 INNTGLLGSYHPGVFRGDKWSCCHQKEKTGQGCDKTRSRVTLQEWNDPLDHDLEAQLIYR 660
           INNTGLLGSYHPGVFRGDKWSCCHQKEKTGQGCDKTRSRVTLQEWNDPLDHDLEAQLI R
Sbjct: 673 INNTGLLGSYHPGVFRGDKWSCCHQKEKTGQGCDKTRSRVTLQEWNDPLDHDLEAQLICR 732

Query: 661 HLLGVEAMLWERHRELSGGAEAGTVPTSPGKVPEDSLARLLRVLQDLREAHSSSPAGSPP 720
           HLLGVEAMLWERHRELSGGAEAGTVPTSPGKVPEDSLARLLRVLQDLREAHSSSPAGSPP
Sbjct: 733 HLLGVEAMLWERHRELSGGAEAGTVPTSPGKVPEDSLARLLRVLQDLREAHSSSPAGSPP 792

Query: 721 SEPNCLLELQT 731
           SEPNCLLELQT
Sbjct: 793 SEPNCLLELQT 803



 Score = 43.5 bits (101), Expect = 7e-04
 Identities = 27/89 (30%), Positives = 44/89 (49%), Gaps = 2/89 (2%)

Query: 58  ARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGR-TRETSIVKKSCYPRWNETFEFEL 116
           A+   L   ++E ++L  KD  G+SDP+  V+        T+ V K+  P W E ++  L
Sbjct: 2   AKRSSLYIRIVEGKNLPAKDITGSSDPYCIVKVDNEPIIRTATVWKTLCPFWGEEYQVHL 61

Query: 117 QEGAMEALCVEAWDWDLVSRNDFLGKVVI 145
                 A+     D D +SR+D +GKV +
Sbjct: 62  PP-TFHAVAFYVMDEDALSRDDVIGKVCL 89


>gi|239743307 PREDICTED: similar to calcium-promoted Ras inactivator
           isoform 1 [Homo sapiens]
          Length = 757

 Score = 1356 bits (3510), Expect = 0.0
 Identities = 685/731 (93%), Positives = 685/731 (93%), Gaps = 46/731 (6%)

Query: 1   MDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEIHLRLEVWPGARA 60
           MDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEIHLRLEVWPGARA
Sbjct: 73  MDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEIHLRLEVWPGARA 132

Query: 61  CRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEGA 120
           CRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEGA
Sbjct: 133 CRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEGA 192

Query: 121 MEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGNLGSL 180
           MEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGNLGSL
Sbjct: 193 MEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGNLGSL 252

Query: 181 QLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVATNLLK 240
           QLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVATNLLK
Sbjct: 253 QLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVATNLLK 312

Query: 241 LFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSVESFLKVAGMQYLHGVLGPII 300
           LFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSVESFLKVAGMQYLHGVLGPII
Sbjct: 313 LFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSVESFLKVAGMQYLHGVLGPII 372

Query: 301 NKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSALSRSVR 360
           NKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSALSRSVR
Sbjct: 373 NKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSALSRSVR 432

Query: 361 ACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFHLRERHA 420
           ACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFHLRERHA
Sbjct: 433 ACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFHLRERHA 492

Query: 421 DARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVHQGVAQLKDFITKLVDIEEK 480
           DARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVHQGVAQLKDFITKLVDIEEK
Sbjct: 493 DARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVHQGVAQLKDFITKLVDIEEK 552

Query: 481 DELDLQRTLSLQAPPVKEGPLFIHRTKGKGPLMSSSFKKLYFSLTTEALSFAKTPSSKKS 540
           DELDLQRTLSLQAPPVKEGPLFIHRTKGKGPLMSSSFKKLYFSLTTEALSFAKTPSS   
Sbjct: 553 DELDLQRTLSLQAPPVKEGPLFIHRTKGKGPLMSSSFKKLYFSLTTEALSFAKTPSS--- 609

Query: 541 ALIKLANIRAAEKVEEKSFGGSHVMQVIYTDDAGRPQTAYLQCKCVNELNQWLSALRKVS 600
                                                      KCVNELNQWLSALRKVS
Sbjct: 610 -------------------------------------------KCVNELNQWLSALRKVS 626

Query: 601 INNTGLLGSYHPGVFRGDKWSCCHQKEKTGQGCDKTRSRVTLQEWNDPLDHDLEAQLIYR 660
           INNTGLLGSYHPGVFRGDKWSCCHQKEKTGQGCDKTRSRVTLQEWNDPLDHDLEAQLIYR
Sbjct: 627 INNTGLLGSYHPGVFRGDKWSCCHQKEKTGQGCDKTRSRVTLQEWNDPLDHDLEAQLIYR 686

Query: 661 HLLGVEAMLWERHRELSGGAEAGTVPTSPGKVPEDSLARLLRVLQDLREAHSSSPAGSPP 720
           HLLGVEAMLWERHRELSGGAEAGTVPTSPGKVPEDSLARLLRVLQDLREAHSSSPAGSPP
Sbjct: 687 HLLGVEAMLWERHRELSGGAEAGTVPTSPGKVPEDSLARLLRVLQDLREAHSSSPAGSPP 746

Query: 721 SEPNCLLELQT 731
           SEPNCLLELQT
Sbjct: 747 SEPNCLLELQT 757



 Score = 43.5 bits (101), Expect = 7e-04
 Identities = 27/89 (30%), Positives = 44/89 (49%), Gaps = 2/89 (2%)

Query: 58  ARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGR-TRETSIVKKSCYPRWNETFEFEL 116
           A+   L   ++E ++L  KD  G+SDP+  V+        T+ V K+  P W E ++  L
Sbjct: 2   AKRSSLYIRIVEGKNLPAKDITGSSDPYCIVKVDNEPIIRTATVWKTLCPFWGEEYQVHL 61

Query: 117 QEGAMEALCVEAWDWDLVSRNDFLGKVVI 145
                 A+     D D +SR+D +GKV +
Sbjct: 62  PP-TFHAVAFYVMDEDALSRDDVIGKVCL 89


>gi|239508990 PREDICTED: similar to calcium-promoted Ras inactivator
           isoform 2 [Homo sapiens]
          Length = 757

 Score = 1356 bits (3510), Expect = 0.0
 Identities = 685/731 (93%), Positives = 685/731 (93%), Gaps = 46/731 (6%)

Query: 1   MDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEIHLRLEVWPGARA 60
           MDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEIHLRLEVWPGARA
Sbjct: 73  MDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEIHLRLEVWPGARA 132

Query: 61  CRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEGA 120
           CRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEGA
Sbjct: 133 CRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEGA 192

Query: 121 MEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGNLGSL 180
           MEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGNLGSL
Sbjct: 193 MEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGNLGSL 252

Query: 181 QLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVATNLLK 240
           QLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVATNLLK
Sbjct: 253 QLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVATNLLK 312

Query: 241 LFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSVESFLKVAGMQYLHGVLGPII 300
           LFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSVESFLKVAGMQYLHGVLGPII
Sbjct: 313 LFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSVESFLKVAGMQYLHGVLGPII 372

Query: 301 NKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSALSRSVR 360
           NKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSALSRSVR
Sbjct: 373 NKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSALSRSVR 432

Query: 361 ACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFHLRERHA 420
           ACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFHLRERHA
Sbjct: 433 ACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFHLRERHA 492

Query: 421 DARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVHQGVAQLKDFITKLVDIEEK 480
           DARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVHQGVAQLKDFITKLVDIEEK
Sbjct: 493 DARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVHQGVAQLKDFITKLVDIEEK 552

Query: 481 DELDLQRTLSLQAPPVKEGPLFIHRTKGKGPLMSSSFKKLYFSLTTEALSFAKTPSSKKS 540
           DELDLQRTLSLQAPPVKEGPLFIHRTKGKGPLMSSSFKKLYFSLTTEALSFAKTPSS   
Sbjct: 553 DELDLQRTLSLQAPPVKEGPLFIHRTKGKGPLMSSSFKKLYFSLTTEALSFAKTPSS--- 609

Query: 541 ALIKLANIRAAEKVEEKSFGGSHVMQVIYTDDAGRPQTAYLQCKCVNELNQWLSALRKVS 600
                                                      KCVNELNQWLSALRKVS
Sbjct: 610 -------------------------------------------KCVNELNQWLSALRKVS 626

Query: 601 INNTGLLGSYHPGVFRGDKWSCCHQKEKTGQGCDKTRSRVTLQEWNDPLDHDLEAQLIYR 660
           INNTGLLGSYHPGVFRGDKWSCCHQKEKTGQGCDKTRSRVTLQEWNDPLDHDLEAQLIYR
Sbjct: 627 INNTGLLGSYHPGVFRGDKWSCCHQKEKTGQGCDKTRSRVTLQEWNDPLDHDLEAQLIYR 686

Query: 661 HLLGVEAMLWERHRELSGGAEAGTVPTSPGKVPEDSLARLLRVLQDLREAHSSSPAGSPP 720
           HLLGVEAMLWERHRELSGGAEAGTVPTSPGKVPEDSLARLLRVLQDLREAHSSSPAGSPP
Sbjct: 687 HLLGVEAMLWERHRELSGGAEAGTVPTSPGKVPEDSLARLLRVLQDLREAHSSSPAGSPP 746

Query: 721 SEPNCLLELQT 731
           SEPNCLLELQT
Sbjct: 747 SEPNCLLELQT 757



 Score = 43.5 bits (101), Expect = 7e-04
 Identities = 27/89 (30%), Positives = 44/89 (49%), Gaps = 2/89 (2%)

Query: 58  ARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGR-TRETSIVKKSCYPRWNETFEFEL 116
           A+   L   ++E ++L  KD  G+SDP+  V+        T+ V K+  P W E ++  L
Sbjct: 2   AKRSSLYIRIVEGKNLPAKDITGSSDPYCIVKVDNEPIIRTATVWKTLCPFWGEEYQVHL 61

Query: 117 QEGAMEALCVEAWDWDLVSRNDFLGKVVI 145
                 A+     D D +SR+D +GKV +
Sbjct: 62  PP-TFHAVAFYVMDEDALSRDDVIGKVCL 89


>gi|121114292 RAS p21 protein activator 4 isoform 2 [Homo sapiens]
          Length = 757

 Score = 1348 bits (3490), Expect = 0.0
 Identities = 682/731 (93%), Positives = 683/731 (93%), Gaps = 46/731 (6%)

Query: 1   MDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEIHLRLEVWPGARA 60
           MDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEIHLRLEVWPGARA
Sbjct: 73  MDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEIHLRLEVWPGARA 132

Query: 61  CRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEGA 120
           CRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEGA
Sbjct: 133 CRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEGA 192

Query: 121 MEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGNLGSL 180
           MEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGNLGSL
Sbjct: 193 MEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGNLGSL 252

Query: 181 QLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVATNLLK 240
           QLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVATNLLK
Sbjct: 253 QLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVATNLLK 312

Query: 241 LFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSVESFLKVAGMQYLHGVLGPII 300
           LFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKS+ESFLKVAGMQYLHGVLGPII
Sbjct: 313 LFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSMESFLKVAGMQYLHGVLGPII 372

Query: 301 NKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSALSRSVR 360
           NKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSALSRSVR
Sbjct: 373 NKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSALSRSVR 432

Query: 361 ACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFHLRERHA 420
           ACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFHLRERHA
Sbjct: 433 ACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFHLRERHA 492

Query: 421 DARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVHQGVAQLKDFITKLVDIEEK 480
           DARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTV QGVAQLKDFITKLVDIEEK
Sbjct: 493 DARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVRQGVAQLKDFITKLVDIEEK 552

Query: 481 DELDLQRTLSLQAPPVKEGPLFIHRTKGKGPLMSSSFKKLYFSLTTEALSFAKTPSSKKS 540
           DELDLQRTLSLQAPPVKEGPLFIHRTKGKGPLMSSSFKKLYFSLTTEALSFAKTPSS   
Sbjct: 553 DELDLQRTLSLQAPPVKEGPLFIHRTKGKGPLMSSSFKKLYFSLTTEALSFAKTPSS--- 609

Query: 541 ALIKLANIRAAEKVEEKSFGGSHVMQVIYTDDAGRPQTAYLQCKCVNELNQWLSALRKVS 600
                                                      KCVNELNQWLSALRKVS
Sbjct: 610 -------------------------------------------KCVNELNQWLSALRKVS 626

Query: 601 INNTGLLGSYHPGVFRGDKWSCCHQKEKTGQGCDKTRSRVTLQEWNDPLDHDLEAQLIYR 660
           INNTGLLGSYHPGVFRGDKWSCCHQKEKTGQGCDKTRSRVTLQEWNDPLDHDLEAQLI R
Sbjct: 627 INNTGLLGSYHPGVFRGDKWSCCHQKEKTGQGCDKTRSRVTLQEWNDPLDHDLEAQLICR 686

Query: 661 HLLGVEAMLWERHRELSGGAEAGTVPTSPGKVPEDSLARLLRVLQDLREAHSSSPAGSPP 720
           HLLGVEAMLWERHRELSGGAEAGTVPTSPGKVPEDSLARLLRVLQDLREAHSSSPAGSPP
Sbjct: 687 HLLGVEAMLWERHRELSGGAEAGTVPTSPGKVPEDSLARLLRVLQDLREAHSSSPAGSPP 746

Query: 721 SEPNCLLELQT 731
           SEPNCLLELQT
Sbjct: 747 SEPNCLLELQT 757



 Score = 43.5 bits (101), Expect = 7e-04
 Identities = 27/89 (30%), Positives = 44/89 (49%), Gaps = 2/89 (2%)

Query: 58  ARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGR-TRETSIVKKSCYPRWNETFEFEL 116
           A+   L   ++E ++L  KD  G+SDP+  V+        T+ V K+  P W E ++  L
Sbjct: 2   AKRSSLYIRIVEGKNLPAKDITGSSDPYCIVKVDNEPIIRTATVWKTLCPFWGEEYQVHL 61

Query: 117 QEGAMEALCVEAWDWDLVSRNDFLGKVVI 145
                 A+     D D +SR+D +GKV +
Sbjct: 62  PP-TFHAVAFYVMDEDALSRDDVIGKVCL 89


>gi|4759026 RAS protein activator like 1 [Homo sapiens]
          Length = 804

 Score =  620 bits (1599), Expect = e-177
 Identities = 337/722 (46%), Positives = 461/722 (63%), Gaps = 19/722 (2%)

Query: 1   MDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEIHLRLEVWPGARA 60
           +DED +  DD+IGK+ L+R+ I + P+G   W +L+ VDPD EVQGEI L +++    + 
Sbjct: 73  LDEDTVGHDDIIGKISLSREAITADPRGIDSWINLSRVDPDAEVQGEICLSVQMLEDGQG 132

Query: 61  CRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEGA 120
             LRC VL ARDLAP+D +GTSDPF RV +  ++ ETS +KK+ +P W+E  E     GA
Sbjct: 133 RCLRCHVLHARDLAPRDISGTSDPFARVFWGSQSLETSTIKKTRFPHWDEVLELREMPGA 192

Query: 121 MEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGNLGSL 180
              L VE WDWD+V +NDFLG V    + L+  +  +GWFRL P   ++     GNLG+L
Sbjct: 193 PSPLRVELWDWDMVGKNDFLGMVEFSPKTLQQ-KPPKGWFRLLPFP-RAEEDSGGNLGAL 250

Query: 181 QLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQL-----IPLIEETTSTECRQDVA 235
           +++VRL ++ VLPS  YQPL+ LL   V    QGP +      + L+EE T  +CRQD+A
Sbjct: 251 RVKVRLIEDRVLPSQCYQPLMELLMESV----QGPAEEDTASPLALLEELTLGDCRQDLA 306

Query: 236 TNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSVESFLKVAGMQYLHGV 295
           T L+KLFLG+GLA  FLD L + E++RT + NTLFRSNSLASKS+E F+K+ GM YLH V
Sbjct: 307 TKLVKLFLGRGLAGHFLDYLTRREVARTMDPNTLFRSNSLASKSMEQFMKLVGMPYLHEV 366

Query: 296 LGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSAL 355
           L P+I++VFEEKKY+ELDP K+++            +E ++ E S   L  +LG ++ A+
Sbjct: 367 LKPVISRVFEEKKYMELDPCKMDLGRTRRISFKGALSEEQMRETSLGLLTGYLGPIVDAI 426

Query: 356 SRSVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFHL 415
             SV  CP  +R  F+QL RRV ERFP A+H++V ++A++ FL LRFF+PAI++PKLF L
Sbjct: 427 VGSVGRCPPAMRLAFKQLHRRVEERFPQAEHQDVKYLAISGFLFLRFFAPAILTPKLFDL 486

Query: 416 RERHADARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVHQGVAQLKDFITKLV 475
           R++HAD +TSR+LLLLAKAVQ++GN+     + KE WM PL P + Q V++++DF+ +LV
Sbjct: 487 RDQHADPQTSRSLLLLAKAVQSIGNLGQQLGQGKELWMAPLHPFLLQCVSRVRDFLDRLV 546

Query: 476 DIEEKDELDLQRTLSLQAPPVKEGPLFIHRTKGKGPLMSSSFKKLYFSLTTEALSFAKTP 535
           D++  +     R L   +  V+EG L   + +  G     +FKK Y  L+ E LSF+K+P
Sbjct: 547 DVDGDEAGVPARALFPPSAIVREGYLLKRKEEPAGLATRFAFKKRYVWLSGETLSFSKSP 606

Query: 536 SSKKSALIKLANIRAAEKVEEKSFGGSHVMQVIYTDDAGRPQTAYLQCKCVNELNQWLSA 595
             +    I +++IRA E+V+E +F   HVMQV+  D  G   T YLQCK VNELNQWLSA
Sbjct: 607 EWQMCHSIPVSHIRAVERVDEGAFQLPHVMQVVTQDGTGALHTTYLQCKNVNELNQWLSA 666

Query: 596 LRKVSINNTGLLGSYHPGVFRGDKWSCCHQKEKTGQGCDKTRSRVTLQEWNDPLDHDLEA 655
           LRK S  N   L + HPG FR  +W+CC Q E++  GC +T S VTL +W+DPLD D EA
Sbjct: 667 LRKASAPNPNKLAACHPGAFRSARWTCCLQAERSAAGCSRTHSAVTLGDWSDPLDPDAEA 726

Query: 656 QLIYRHLLGVEAMLWERHRELSGGAEAGTVPTSPGKVPE------DSLARLLRVLQDLRE 709
           Q +YR LL     L  R + L       T+    G  PE       + ARLL VL DL  
Sbjct: 727 QTVYRQLLLGRDQL--RLKLLEDSNMDTTLEADTGACPEVLARQRAATARLLEVLADLDR 784

Query: 710 AH 711
           AH
Sbjct: 785 AH 786



 Score = 40.4 bits (93), Expect = 0.006
 Identities = 27/87 (31%), Positives = 40/87 (45%), Gaps = 2/87 (2%)

Query: 58  ARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGR-TRETSIVKKSCYPRWNETFEFEL 116
           A++  L   V+E R L  KD +G+SDP+  V+        T+ V +S  P W E +   L
Sbjct: 2   AKSSSLNVRVVEGRALPAKDVSGSSDPYCLVKVDDEVVARTATVWRSLGPFWGEEYTVHL 61

Query: 117 QEGAMEALCVEAWDWDLVSRNDFLGKV 143
                  L     D D V  +D +GK+
Sbjct: 62  PLD-FHQLAFYVLDEDTVGHDDIIGKI 87


>gi|12545408 RAS p21 protein activator 2 [Homo sapiens]
          Length = 849

 Score =  293 bits (751), Expect = 3e-79
 Identities = 211/723 (29%), Positives = 349/723 (48%), Gaps = 65/723 (8%)

Query: 2   DEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEIHLRLE----VWPG 57
           D++ L RD  IGKV + ++ + +H  G   W  L  VD + EVQG++HL L+    +   
Sbjct: 108 DKNVLQRDLRIGKVAIKKEDLCNH-SGKETWFSLQPVDSNSEVQGKVHLELKLNELITEN 166

Query: 58  ARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTR----ETSIVKKSCYPRWNETF- 112
              C+     ++A    P     + DP+  V   G +R    +T + KK+  P++NE F 
Sbjct: 167 GTVCQQLVVHIKACHGLPLINGQSCDPYATVSLVGPSRNDQKKTKVKKKTSNPQFNEIFY 226

Query: 113 -------------EFELQEGAMEAL--CVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEE 157
                        +F+++E  +E L   ++ W+   + ++ FLG++ + V  LR     +
Sbjct: 227 FEVTRSSSYTRKSQFQVEEEDIEKLEIRIDLWNNGNLVQDVFLGEIKVPVNVLRTDSSHQ 286

Query: 158 GWFRLQPDQSKSRRHDEGNLGSLQLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQ 217
            W+ LQP  + ++     +LGSL+L +   ++ VLPS YY PL  LL     +       
Sbjct: 287 AWYLLQPRDNGNKSSKTDDLGSLRLNICYTEDYVLPSEYYGPLKTLLLKSPDVQPISASA 346

Query: 218 LIPLIEETTSTECRQDVATNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLAS 277
              L E       + D    L++L L       F   + +L+L  T + NT+FR NSLA+
Sbjct: 347 AYILSEICRD---KNDAVLPLVRLLLHHDKLVPFATAVAELDLKDTQDANTIFRGNSLAT 403

Query: 278 KSVESFLKVAGMQYLHGVLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVL 337
           + ++  +K+ G  YL   L PI++++ +  K  E+DP K++              E + +
Sbjct: 404 RCLDEMMKIVGGHYLKVTLKPILDEICDSSKSCEIDPIKLK--------------EGDNV 449

Query: 338 EQSAQTLRAHLGALLSALSRSVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSF 397
           E + + LR ++  L + + +S  +CP V+   F  L +   +RFP   H  V + AV+SF
Sbjct: 450 ENNKENLRYYVDKLFNTIVKSSMSCPTVMCDIFYSLRQMATQRFPNDPH--VQYSAVSSF 507

Query: 398 LCLRFFSPAIMSPKLFHLRERHADARTSRTLLLLAKAVQNV---GNMDTPASRAKEAWM- 453
           + LRFF+ A++SP  FHLR  H DA+T RTL L++K +Q +   G++    S  KE +M 
Sbjct: 508 VFLRFFAVAVVSPHTFHLRPHHPDAQTIRTLTLISKTIQTLGSWGSLSKSKSSFKETFMC 567

Query: 454 EPLQPTVHQG-VAQLKDFITKLVDIEEKDELDLQRTLSLQAPPVKEGPLFIHRTKGKGPL 512
           E  +    +G +  +K F+ ++   E K+       + L     KEG ++  R +G+  +
Sbjct: 568 EFFKMFQEEGYIIAVKKFLDEISSTETKESSGTSEPVHL-----KEGEMY-KRAQGRTRI 621

Query: 513 MSSSFKKLYFSLTTEALSFAKTPSSKKSALIKLANIRAAEKVEEKSFGGSHVMQVIYTDD 572
              +FKK +F LT+  L++ K P       I + NI A EK+EE SF   ++ QVI+T+ 
Sbjct: 622 GKKNFKKRWFCLTSRELTYHKQPGKDAIYTIPVKNILAVEKLEESSFNKKNMFQVIHTE- 680

Query: 573 AGRPQTAYLQCKCVNELNQWLSALRKVSINNTGLLGSYHPGVFRGDKWSCCHQKEKTGQG 632
               +  Y+Q     E N+W+  L +VS  N   L  YHP V+    W CC +  +   G
Sbjct: 681 ----KPLYVQANNCVEANEWIDVLCRVSRCNQNRLSFYHPSVYLNGNWLCCQETGENTLG 736

Query: 633 CDKTRSRVTLQEWNDPLDHDLEAQLIYRHLLGVEAMLWERHRELSGGAEAGTVPTSPGKV 692
           C    + V      D +D D E + IY  L  +  +  ++  E  G      V   P K 
Sbjct: 737 CKPCTAGVPADIQID-IDEDRETERIY-SLFTLSLLKLQKMEEACGTI---AVYQGPQKE 791

Query: 693 PED 695
           P+D
Sbjct: 792 PDD 794



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 44/152 (28%), Positives = 71/152 (46%), Gaps = 10/152 (6%)

Query: 63  LRCSVLEARDLAPK-DRNGTSDPFVRVRY-KGRTRETSIVKKSCYPRWNETFEFELQEGA 120
           LR  + EA++L P    +   D F  +   +     T +V+KS  P ++E F FE+    
Sbjct: 40  LRGKICEAKNLLPYLGPHKMRDCFCTINLDQEEVYRTQVVEKSLSPFFSEEFYFEIPR-T 98

Query: 121 MEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGNLGSL 180
            + L    +D +++ R+  +GKV I  + L     +E WF LQP  S S        G +
Sbjct: 99  FQYLSFYVYDKNVLQRDLRIGKVAIKKEDLCNHSGKETWFSLQPVDSNSEVQ-----GKV 153

Query: 181 QLEVRLRDETVLPSSYYQPL-VHL-LCHEVKL 210
            LE++L +      +  Q L VH+  CH + L
Sbjct: 154 HLELKLNELITENGTVCQQLVVHIKACHGLPL 185


>gi|38201692 RAS p21 protein activator 3 [Homo sapiens]
          Length = 834

 Score =  283 bits (725), Expect = 3e-76
 Identities = 206/687 (29%), Positives = 328/687 (47%), Gaps = 63/687 (9%)

Query: 2   DEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEIHLRLEVWP----- 56
           D D   RD +IGKV + ++ +  +    + W  L  VD D EVQG++HL L +       
Sbjct: 82  DRDVFRRDSIIGKVAIQKEDLQKYHNRDT-WFQLQHVDADSEVQGKVHLELRLSEVITDT 140

Query: 57  GARACRLRCSVLEARDLAPKDRNGTSDPFVRVR----YKGRTRETSIVKKSCYPRWNETF 112
           G    +L   ++E + L     NG  DP+  V     ++   ++T + +K+  P+++E F
Sbjct: 141 GVVCHKLATRIVECQGLPIV--NGQCDPYATVTLAGPFRSEAKKTKVKRKTNNPQFDEVF 198

Query: 113 EFEL--------------QEGAMEALCVEAWDWD---LVSRNDFLGKVVIDVQRLRVVQQ 155
            FE+              +E  ++ L +    W+   L   ++FLG++ I ++ LR    
Sbjct: 199 YFEVTRPCSYSKKSHFDFEEEDVDKLEIRVDLWNASNLKFGDEFLGELRIPLKVLRQSSS 258

Query: 156 EEGWFRLQPDQSKSRRHDEGNLGSLQLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGP 215
            E W+ LQP  + S+     +LGSL+L V   ++ V  S YY PL  LL     +     
Sbjct: 259 YEAWYFLQPRDNGSKSLKPDDLGSLRLNVVYTEDHVFSSDYYSPLRDLLLKSADVEPVSA 318

Query: 216 GQLIPLIEETTSTECRQDVATNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSL 275
                L E       +Q+ A  L++LFL  G    F+  +   E+ RT + NT+FR NSL
Sbjct: 319 SAAHILGEVCRE---KQEAAVPLVRLFLHYGRVVPFISAIASAEVKRTQDPNTIFRGNSL 375

Query: 276 ASKSVESFLKVAGMQYLHGVLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAE 335
           ASK ++  +K+AGM YLH  L P I ++ +  K  E+DP K++              + E
Sbjct: 376 ASKCIDETMKLAGMHYLHVTLKPAIEEICQSHKPCEIDPVKLK--------------DGE 421

Query: 336 VLEQSAQTLRAHLGALLSALSRSVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVT 395
            LE + + LR ++  +  A++ S  +CP V+   F  L     +RF      +V + AV+
Sbjct: 422 NLENNMENLRQYVDRVFHAITESGVSCPTVMCDIFFSLREAAAKRF--QDDPDVRYTAVS 479

Query: 396 SFLCLRFFSPAIMSPKLFHLRERHADARTSRTLLLLAKAVQNVGNMDTPASRA-KEAWME 454
           SF+ LRFF+PAI+SP LF L   H D +TSRTL L++K VQ +G++    S + KE++M 
Sbjct: 480 SFIFLRFFAPAILSPNLFQLTPHHTDPQTSRTLTLISKTVQTLGSLSKSKSASFKESYMA 539

Query: 455 PLQPTVHQG--VAQLKDFITKLVDIEEKDELDLQRTLSLQAPPVKEGPLFIHRTKGKGPL 512
                 ++      +K+F+  +     +D   +++ + L     KEG   I R +G+   
Sbjct: 540 TFYEFFNEQKYADAVKNFLDLISSSGRRDPKSVEQPIVL-----KEG-FMIKRAQGRKRF 593

Query: 513 MSSSFKKLYFSLTTEALSFAKTPSSKKSALIKLANIRAAEKVEEKSFGGSHVMQVIYTDD 572
              +FKK +F LT    ++ K+   +    I + NI A EK+EE+SF   ++ QVI  + 
Sbjct: 594 GMKNFKKRWFRLTNHEFTYHKSKGDQPLYSIPIENILAVEKLEEESFKMKNMFQVIQPER 653

Query: 573 AGRPQTAYLQCKCVNELNQWLSALRKVSINNTGLLGSYHPGVFRGDKWSCCHQKEKTGQG 632
           A      Y+Q     E   W+  L KVS  N   L  YHP  +    W CC     +  G
Sbjct: 654 A-----LYIQANNCVEAKDWIDILTKVSQCNQKRLTVYHPSAYLSGHWLCCRAPSDSAPG 708

Query: 633 CDKTRSRVTLQEWNDPLDHDLEAQLIY 659
           C      +      D +D D E + IY
Sbjct: 709 CSPCTGGLPANIQLD-IDGDRETERIY 734



 Score = 40.8 bits (94), Expect = 0.005
 Identities = 28/92 (30%), Positives = 44/92 (47%), Gaps = 6/92 (6%)

Query: 97  TSIVKKSCYPRWNETFEFELQEGAMEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQE 156
           T IV+KS  P + E F  E+   +   L    +D D+  R+  +GKV I  + L+     
Sbjct: 50  TKIVEKSLCPFYGEDFYCEIPR-SFRHLSFYIFDRDVFRRDSIIGKVAIQKEDLQKYHNR 108

Query: 157 EGWFRLQPDQSKSRRHDEGNLGSLQLEVRLRD 188
           + WF+LQ   + S        G + LE+RL +
Sbjct: 109 DTWFQLQHVDADSEVQ-----GKVHLELRLSE 135


>gi|226958575 RAS protein activator like 2 isoform 2 [Homo sapiens]
          Length = 1280

 Score =  132 bits (333), Expect = 9e-31
 Identities = 117/407 (28%), Positives = 189/407 (46%), Gaps = 54/407 (13%)

Query: 49  HLRLEVWPGARACR-----LRCSVLEARDLAPKDRNGTS---DPFVRVRYKGRTRETSIV 100
           +LR  V P    CR     LR  ++EA+DLAPK +       D  +  R   +T+  +I 
Sbjct: 300 NLRRTVQPNKDNCRRAENVLRLWIIEAKDLAPKKKYFCELCLDDTLFARTTSKTKADNIF 359

Query: 101 KKSCYPRWNETFEFELQEGAMEALCVEAWDWDLVSR-----NDFLGKVVIDVQRLRVVQQ 155
                  W E FEF      + ++ V  +  D+  +     N+++G V I    +   Q 
Sbjct: 360 -------WGEHFEF-FSLPPLHSITVHIYK-DVEKKKKKDKNNYVGLVNIPTASVTGRQF 410

Query: 156 EEGWFRLQ-PDQSKSRRHDEGNLGSLQLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQG 214
            E W+ +  P  +K +        S++++ R +  T+LP   Y+     +     +    
Sbjct: 411 VEKWYPVSTPTPNKGKTGGP----SIRIKSRFQTITILPMEQYKEFAEFVTSNYTM---- 462

Query: 215 PGQLIPLIEETTSTECRQDVATNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTL-FRSN 273
              L  ++E   S   ++++A  L+ +    G AKDFL  L   E+ R  E + L FR N
Sbjct: 463 ---LCSVLEPVISVRNKEELACALVHILQSTGRAKDFLTDLVMSEVDRCGEHDVLIFREN 519

Query: 274 SLASKSVESFLKVAGMQYLHGVLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTE 333
           ++A+KS+E +LK+ G QYLH  LG  I  ++E  +  E+DPSK       CS        
Sbjct: 520 TIATKSIEEYLKLVGQQYLHDALGEFIKALYESDENCEVDPSK-------CSS------- 565

Query: 334 AEVLEQSAQTLRAHLGALLSALSRSVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIA 393
           +E+++  +  L+         +  S    P  ++  F    ++   R  G Q  +   I+
Sbjct: 566 SELIDHQSN-LKMCCELAFCKIINSYCVFPRELKEVFASWKQQCLNR--GKQDISERLIS 622

Query: 394 VTSFLCLRFFSPAIMSPKLFHLRERHADARTSRTLLLLAKAVQNVGN 440
            + FL  RF  PAIMSP LF+L + + D RTSRTL L+AK +QN+ N
Sbjct: 623 ASLFL--RFLCPAIMSPSLFNLMQEYPDDRTSRTLTLIAKVIQNLAN 667


>gi|4758808 RAS protein activator like 2 isoform 1 [Homo sapiens]
          Length = 1139

 Score =  132 bits (333), Expect = 9e-31
 Identities = 117/407 (28%), Positives = 189/407 (46%), Gaps = 54/407 (13%)

Query: 49  HLRLEVWPGARACR-----LRCSVLEARDLAPKDRNGTS---DPFVRVRYKGRTRETSIV 100
           +LR  V P    CR     LR  ++EA+DLAPK +       D  +  R   +T+  +I 
Sbjct: 152 NLRRTVQPNKDNCRRAENVLRLWIIEAKDLAPKKKYFCELCLDDTLFARTTSKTKADNIF 211

Query: 101 KKSCYPRWNETFEFELQEGAMEALCVEAWDWDLVSR-----NDFLGKVVIDVQRLRVVQQ 155
                  W E FEF      + ++ V  +  D+  +     N+++G V I    +   Q 
Sbjct: 212 -------WGEHFEF-FSLPPLHSITVHIYK-DVEKKKKKDKNNYVGLVNIPTASVTGRQF 262

Query: 156 EEGWFRLQ-PDQSKSRRHDEGNLGSLQLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQG 214
            E W+ +  P  +K +        S++++ R +  T+LP   Y+     +     +    
Sbjct: 263 VEKWYPVSTPTPNKGKTGGP----SIRIKSRFQTITILPMEQYKEFAEFVTSNYTM---- 314

Query: 215 PGQLIPLIEETTSTECRQDVATNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTL-FRSN 273
              L  ++E   S   ++++A  L+ +    G AKDFL  L   E+ R  E + L FR N
Sbjct: 315 ---LCSVLEPVISVRNKEELACALVHILQSTGRAKDFLTDLVMSEVDRCGEHDVLIFREN 371

Query: 274 SLASKSVESFLKVAGMQYLHGVLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTE 333
           ++A+KS+E +LK+ G QYLH  LG  I  ++E  +  E+DPSK       CS        
Sbjct: 372 TIATKSIEEYLKLVGQQYLHDALGEFIKALYESDENCEVDPSK-------CSS------- 417

Query: 334 AEVLEQSAQTLRAHLGALLSALSRSVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIA 393
           +E+++  +  L+         +  S    P  ++  F    ++   R  G Q  +   I+
Sbjct: 418 SELIDHQSN-LKMCCELAFCKIINSYCVFPRELKEVFASWKQQCLNR--GKQDISERLIS 474

Query: 394 VTSFLCLRFFSPAIMSPKLFHLRERHADARTSRTLLLLAKAVQNVGN 440
            + FL  RF  PAIMSP LF+L + + D RTSRTL L+AK +QN+ N
Sbjct: 475 ASLFL--RFLCPAIMSPSLFNLMQEYPDDRTSRTLTLIAKVIQNLAN 519


>gi|41281683 disabled homolog 2 interacting protein isoform 2 [Homo
           sapiens]
          Length = 1065

 Score =  118 bits (295), Expect = 2e-26
 Identities = 113/443 (25%), Positives = 192/443 (43%), Gaps = 54/443 (12%)

Query: 63  LRCSVLEARDLAPKDRNGTS---DPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEG 119
           L+  V+EA+DL  K +       D  +  R  G+ +  ++        W E FEF     
Sbjct: 91  LKLWVIEAKDLPAKKKYLCELCLDDVLYARTTGKLKTDNVF-------WGEHFEFHNLPP 143

Query: 120 AMEA---LCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGN 176
                  L  E        RN +LG V +    +   Q  E W+   P  + + +  +G 
Sbjct: 144 LRTVTVHLYRETDKKKKKERNSYLGLVSLPAASVAGRQFVEKWY---PVVTPNPKGGKGP 200

Query: 177 LGSLQLEVRLRDETVLPSSYYQPLV-HLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVA 235
              ++++ R +  T+LP   Y+    H+  H + L           +E   S + ++++A
Sbjct: 201 GPMIRIKARYQTITILPMEMYKEFAEHITNHYLGL--------CAALEPILSAKTKEEMA 252

Query: 236 TNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTL-FRSNSLASKSVESFLKVAGMQYLHG 294
           + L+ +    G  KDFL  L   E+ R  +   L FR N+LA+K++E +LK+ G +YL  
Sbjct: 253 SALVHILQSTGKVKDFLTDLMMSEVDRCGDNEHLIFRENTLATKAIEEYLKLVGQKYLQD 312

Query: 295 VLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSA 354
            LG  I  ++E  +  E+DPSK       CS    P+ +          L+         
Sbjct: 313 ALGEFIKALYESDENCEVDPSK-------CSAADLPEHQGN--------LKMCCELAFCK 357

Query: 355 LSRSVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFH 414
           +  S    P  ++    ++F   R+        ++    +++ L LRF  PAIMSP LF+
Sbjct: 358 IINSYCVFPRELK----EVFASWRQECSSRGRPDISERLISASLFLRFLCPAIMSPSLFN 413

Query: 415 LRERHADARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVHQGVAQLKDFITKL 474
           L + + D RT+RTL L+AK  QN+ N     S  KE +M  +   +      ++ F+ ++
Sbjct: 414 LLQEYPDDRTARTLTLIAKVTQNLANFAKFGS--KEEYMSFMNQFLEHEWTNMQRFLLEI 471

Query: 475 VDIEE-------KDELDLQRTLS 490
            + E        +  +DL R LS
Sbjct: 472 SNPETLSNTAGFEGYIDLGRELS 494


>gi|94967023 disabled homolog 2 interacting protein isoform 1 [Homo
           sapiens]
          Length = 1132

 Score =  118 bits (295), Expect = 2e-26
 Identities = 113/443 (25%), Positives = 192/443 (43%), Gaps = 54/443 (12%)

Query: 63  LRCSVLEARDLAPKDRNGTS---DPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEG 119
           L+  V+EA+DL  K +       D  +  R  G+ +  ++        W E FEF     
Sbjct: 187 LKLWVIEAKDLPAKKKYLCELCLDDVLYARTTGKLKTDNVF-------WGEHFEFHNLPP 239

Query: 120 AMEA---LCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGN 176
                  L  E        RN +LG V +    +   Q  E W+   P  + + +  +G 
Sbjct: 240 LRTVTVHLYRETDKKKKKERNSYLGLVSLPAASVAGRQFVEKWY---PVVTPNPKGGKGP 296

Query: 177 LGSLQLEVRLRDETVLPSSYYQPLV-HLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVA 235
              ++++ R +  T+LP   Y+    H+  H + L           +E   S + ++++A
Sbjct: 297 GPMIRIKARYQTITILPMEMYKEFAEHITNHYLGL--------CAALEPILSAKTKEEMA 348

Query: 236 TNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTL-FRSNSLASKSVESFLKVAGMQYLHG 294
           + L+ +    G  KDFL  L   E+ R  +   L FR N+LA+K++E +LK+ G +YL  
Sbjct: 349 SALVHILQSTGKVKDFLTDLMMSEVDRCGDNEHLIFRENTLATKAIEEYLKLVGQKYLQD 408

Query: 295 VLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSA 354
            LG  I  ++E  +  E+DPSK       CS    P+ +          L+         
Sbjct: 409 ALGEFIKALYESDENCEVDPSK-------CSAADLPEHQGN--------LKMCCELAFCK 453

Query: 355 LSRSVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFH 414
           +  S    P  ++    ++F   R+        ++    +++ L LRF  PAIMSP LF+
Sbjct: 454 IINSYCVFPRELK----EVFASWRQECSSRGRPDISERLISASLFLRFLCPAIMSPSLFN 509

Query: 415 LRERHADARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVHQGVAQLKDFITKL 474
           L + + D RT+RTL L+AK  QN+ N     S  KE +M  +   +      ++ F+ ++
Sbjct: 510 LLQEYPDDRTARTLTLIAKVTQNLANFAKFGS--KEEYMSFMNQFLEHEWTNMQRFLLEI 567

Query: 475 VDIEE-------KDELDLQRTLS 490
            + E        +  +DL R LS
Sbjct: 568 SNPETLSNTAGFEGYIDLGRELS 590


>gi|194248068 synaptic Ras GTPase activating protein 1 [Homo
           sapiens]
          Length = 1343

 Score =  115 bits (289), Expect = 1e-25
 Identities = 107/410 (26%), Positives = 179/410 (43%), Gaps = 56/410 (13%)

Query: 63  LRCSVLEARDLAPKDRNGTS---DPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEG 119
           L+  ++EAR+L PK R       D  +  R   + R  S         W E FEF     
Sbjct: 264 LKLWIIEARELPPKKRYYCELCLDDMLYARTTSKPRSAS----GDTVFWGEHFEFN-NLP 318

Query: 120 AMEALCVEAW-DWDLVSRND---FLGKVVIDVQRLRVVQQEEGWFRLQPDQSK------- 168
           A+ AL +  + D D   + D   ++G V + V  L      E W+ +             
Sbjct: 319 AVRALRLHLYRDSDKKRKKDKAGYVGLVTVPVATLAGRHFTEQWYPVTLPTGSGGSGGMG 378

Query: 169 ----------SRRHDEGNLGSLQLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQL 218
                     S    +G   +++L+ R +  ++LP   Y+     + +  ++       L
Sbjct: 379 SGGGGGSGGGSGGKGKGGCPAVRLKARYQTMSILPMELYKEFAEYVTNHYRM-------L 431

Query: 219 IPLIEETTSTECRQDVATNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTL-FRSNSLAS 277
             ++E   + + +++VA+ L+ +    G AKDFL  +   E+ R  E   L FR N+LA+
Sbjct: 432 CAVLEPALNVKGKEEVASALVHILQSTGKAKDFLSDMAMSEVDRFMEREHLIFRENTLAT 491

Query: 278 KSVESFLKVAGMQYLHGVLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVL 337
           K++E ++++ G +YL   +G  I  ++E ++  E+DP K       C+        A  L
Sbjct: 492 KAIEEYMRLIGQKYLKDAIGEFIRALYESEENCEVDPIK-------CT--------ASSL 536

Query: 338 EQSAQTLRAHLGALLSALSRSVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSF 397
            +    LR      L  +  S    P  ++  F     R  ER      E++    +++ 
Sbjct: 537 AEHQANLRMCCELALCKVVNSHCVFPRELKEVFASWRLRCAER----GREDIADRLISAS 592

Query: 398 LCLRFFSPAIMSPKLFHLRERHADARTSRTLLLLAKAVQNVGNMDTPASR 447
           L LRF  PAIMSP LF L + + D +TSRTL L+AK +QN+ N     S+
Sbjct: 593 LFLRFLCPAIMSPSLFGLMQEYPDEQTSRTLTLIAKVIQNLANFSKFTSK 642


>gi|4506431 RAS p21 protein activator 1 isoform 1 [Homo sapiens]
          Length = 1047

 Score =  105 bits (263), Expect = 1e-22
 Identities = 89/326 (27%), Positives = 148/326 (45%), Gaps = 46/326 (14%)

Query: 178 GSLQLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQD---V 234
           GSL++  R   E ++P   Y     L+  +              +    S  C QD   +
Sbjct: 704 GSLRVRARYSMEKIMPEEEYSEFKELILQKELH-----------VVYALSHVCGQDRTLL 752

Query: 235 ATNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSVESFLKVAGMQYLHG 294
           A+ LL++FL + L    L  L   E+S   E  TLFR+ +LAS  +E ++K    Q++H 
Sbjct: 753 ASILLRIFLHEKLESLLLCTLNDREISMEDEATTLFRATTLASTLMEQYMKATATQFVHH 812

Query: 295 VLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSA 354
            L   I K+ E K+  EL PSK+E                    +   T   HL  +LS 
Sbjct: 813 ALKDSILKIMESKQSCELSPSKLE------------------KNEDVNTNLTHLLNILSE 854

Query: 355 LSRSVRACPAVVRATFRQLF----RRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSP 410
           L   +     ++  T R ++    + V+ ++P   +  +    V+ F+ LR   PAI++P
Sbjct: 855 LVEKIFMASEILPPTLRYIYGCLQKSVQHKWP--TNTTMRTRVVSGFVFLRLICPAILNP 912

Query: 411 KLFHLRERHADARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTV----HQGVAQ 466
           ++F++         +RTL+L+AK+VQN+ N+      AKE +ME + P +    H+ +  
Sbjct: 913 RMFNIISDSPSPIAARTLILVAKSVQNLANL--VEFGAKEPYMEGVNPFIKSNKHRMIMF 970

Query: 467 LKDF--ITKLVDIEEKDELDLQRTLS 490
           L +   + +L D  E    DL R L+
Sbjct: 971 LDELGNVPELPDTTEHSRTDLSRDLA 996


>gi|12545406 RAS p21 protein activator 1 isoform 2 [Homo sapiens]
          Length = 870

 Score =  105 bits (263), Expect = 1e-22
 Identities = 89/326 (27%), Positives = 148/326 (45%), Gaps = 46/326 (14%)

Query: 178 GSLQLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQD---V 234
           GSL++  R   E ++P   Y     L+  +              +    S  C QD   +
Sbjct: 527 GSLRVRARYSMEKIMPEEEYSEFKELILQKELH-----------VVYALSHVCGQDRTLL 575

Query: 235 ATNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSVESFLKVAGMQYLHG 294
           A+ LL++FL + L    L  L   E+S   E  TLFR+ +LAS  +E ++K    Q++H 
Sbjct: 576 ASILLRIFLHEKLESLLLCTLNDREISMEDEATTLFRATTLASTLMEQYMKATATQFVHH 635

Query: 295 VLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSA 354
            L   I K+ E K+  EL PSK+E                    +   T   HL  +LS 
Sbjct: 636 ALKDSILKIMESKQSCELSPSKLE------------------KNEDVNTNLTHLLNILSE 677

Query: 355 LSRSVRACPAVVRATFRQLF----RRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSP 410
           L   +     ++  T R ++    + V+ ++P   +  +    V+ F+ LR   PAI++P
Sbjct: 678 LVEKIFMASEILPPTLRYIYGCLQKSVQHKWP--TNTTMRTRVVSGFVFLRLICPAILNP 735

Query: 411 KLFHLRERHADARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTV----HQGVAQ 466
           ++F++         +RTL+L+AK+VQN+ N+      AKE +ME + P +    H+ +  
Sbjct: 736 RMFNIISDSPSPIAARTLILVAKSVQNLANL--VEFGAKEPYMEGVNPFIKSNKHRMIMF 793

Query: 467 LKDF--ITKLVDIEEKDELDLQRTLS 490
           L +   + +L D  E    DL R L+
Sbjct: 794 LDELGNVPELPDTTEHSRTDLSRDLA 819


>gi|130502162 RAS protein activator like 3 [Homo sapiens]
          Length = 1011

 Score = 87.0 bits (214), Expect = 5e-17
 Identities = 76/303 (25%), Positives = 135/303 (44%), Gaps = 31/303 (10%)

Query: 179 SLQLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVATNL 238
           +L+  +R R   VLPS  Y+ L   L            +L   +E     + ++++A  +
Sbjct: 414 ALRARIRARRLRVLPSERYKELAEFLTFHY-------ARLCGALEPALPAQAKEELAAAM 466

Query: 239 LKLFLGQGLAKDFLDLLFQLELSRTSETNTL-FRSNSLASKSVESFLKVAGMQYLHGVLG 297
           +++    G A+  +  L   EL+R      L FR N+LA+K+++ ++K+    YL   LG
Sbjct: 467 VRVLRATGRAQALVTDLGTAELARCGGREALLFRENTLATKAIDEYMKLVAQDYLQETLG 526

Query: 298 PIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSALSR 357
            ++ ++    +  E+DPSK       C     P+ +A         LR     +   +  
Sbjct: 527 QVVRRLCASTEDCEVDPSK-------CPASELPEHQAR--------LRNSCEEVFETIIH 571

Query: 358 SVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFHLRE 417
           S    PA +   F       +ER  G++      +  + F  LR   PAI++P LF L  
Sbjct: 572 SYDWFPAELGIVFSSWREACKER--GSEVLGPRLVCASLF--LRLLCPAILAPSLFGLAP 627

Query: 418 RHADARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVHQGVAQLKDFITK--LV 475
            H     +RTL L+AK +QN+ N   P    KEA+M  +   + +    ++ F+ +  +V
Sbjct: 628 DHPAPGPARTLTLIAKVIQNLANR-APFGE-KEAYMGFMNSFLEEHGPAMQCFLDQVAMV 685

Query: 476 DIE 478
           D++
Sbjct: 686 DVD 688


>gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens]
          Length = 671

 Score = 84.0 bits (206), Expect = 5e-16
 Identities = 43/102 (42%), Positives = 63/102 (61%), Gaps = 7/102 (6%)

Query: 67  VLEARDLAPKDRNGTSDPFVRVRY----KGRTRE-TSIVKKSCYPRWNETFEFELQEGAM 121
           V +A++L P D NG SDP+V+++     K  +++ T  +K S  P WNETF F+L+E   
Sbjct: 177 VRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQLKESDK 236

Query: 122 EA-LCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRL 162
           +  L VE WDWDL SRNDF+G +   +  L+     +GWF+L
Sbjct: 237 DRRLSVEIWDWDLTSRNDFMGSLSFGISELQKA-SVDGWFKL 277


>gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens]
          Length = 673

 Score = 84.0 bits (206), Expect = 5e-16
 Identities = 43/102 (42%), Positives = 63/102 (61%), Gaps = 7/102 (6%)

Query: 67  VLEARDLAPKDRNGTSDPFVRVRY----KGRTRE-TSIVKKSCYPRWNETFEFELQEGAM 121
           V +A++L P D NG SDP+V+++     K  +++ T  +K S  P WNETF F+L+E   
Sbjct: 177 VRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQLKESDK 236

Query: 122 EA-LCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRL 162
           +  L VE WDWDL SRNDF+G +   +  L+     +GWF+L
Sbjct: 237 DRRLSVEIWDWDLTSRNDFMGSLSFGISELQKA-SVDGWFKL 277


>gi|13384594 protein kinase C, gamma [Homo sapiens]
          Length = 697

 Score = 81.3 bits (199), Expect = 3e-15
 Identities = 49/119 (41%), Positives = 68/119 (57%), Gaps = 8/119 (6%)

Query: 50  LRLEVWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTR-----ETSIVKKSC 104
           L+LE+     A  +  +V EAR+L P D NG SDP+V+++     R     +T  VK + 
Sbjct: 161 LQLEI-RAPTADEIHVTVGEARNLIPMDPNGLSDPYVKLKLIPDPRNLTKQKTRTVKATL 219

Query: 105 YPRWNETFEFELQEGAMEA-LCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRL 162
            P WNETF F L+ G +E  L VE WDWD  SRNDF+G +   V  L +    +GW++L
Sbjct: 220 NPVWNETFVFNLKPGDVERRLSVEVWDWDRTSRNDFMGAMSFGVSEL-LKAPVDGWYKL 277


>gi|4506067 protein kinase C, alpha [Homo sapiens]
          Length = 672

 Score = 79.0 bits (193), Expect = 1e-14
 Identities = 44/126 (34%), Positives = 73/126 (57%), Gaps = 11/126 (8%)

Query: 43  EVQGEIHLRLEVWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRY----KGRTRE-T 97
           E +G I+L+ EV       +L  +V +A++L P D NG SDP+V+++     K  +++ T
Sbjct: 157 EKRGRIYLKAEVADE----KLHVTVRDAKNLIPMDPNGLSDPYVKLKLIPDPKNESKQKT 212

Query: 98  SIVKKSCYPRWNETFEFELQEGAMEA-LCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQE 156
             ++ +  P+WNE+F F+L+    +  L VE WDWD  +RNDF+G +   V  L +    
Sbjct: 213 KTIRSTLNPQWNESFTFKLKPSDKDRRLSVEIWDWDRTTRNDFMGSLSFGVSEL-MKMPA 271

Query: 157 EGWFRL 162
            GW++L
Sbjct: 272 SGWYKL 277


>gi|4557793 neurofibromin isoform 2 [Homo sapiens]
          Length = 2818

 Score = 77.0 bits (188), Expect = 6e-14
 Identities = 71/256 (27%), Positives = 114/256 (44%), Gaps = 27/256 (10%)

Query: 189  ETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVATNLLKLFLGQGLA 248
            ETVL +  ++ LV L+     +G QG   +   +          ++A  L+ LF  + L 
Sbjct: 1198 ETVL-ADRFERLVELV---TMMGDQGELPIAMALANVVPCSQWDELARVLVTLFDSRHLL 1253

Query: 249  KDFLDLLFQLELSRTSETNTLFRSNSLASKSVESFLKVAGMQYLHGVLGPIINKVFEEKK 308
               L  +F  E+       TLFR NSLASK +    KV G  YL  +L P++  V     
Sbjct: 1254 YQLLWNMFSKEVELADSMQTLFRGNSLASKIMTFCFKVYGATYLQKLLDPLLRIVITSSD 1313

Query: 309  Y----VELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSALSRSVRACPA 364
            +     E+DP+++E               +E LE++ + L         A+  S    P 
Sbjct: 1314 WQHVSFEVDPTRLE--------------PSESLEENQRNLLQMTEKFFHAIISSSSEFPP 1359

Query: 365  VVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFHLRERHADART 424
             +R+    L++ V +RFP          AV S + LRF +PAI+SP    + ++    R 
Sbjct: 1360 QLRSVCHCLYQVVSQRFP-----QNSIGAVGSAMFLRFINPAIVSPYEAGILDKKPPPRI 1414

Query: 425  SRTLLLLAKAVQNVGN 440
             R L L++K +Q++ N
Sbjct: 1415 ERGLKLMSKILQSIAN 1430


>gi|150170670 piccolo isoform 2 [Homo sapiens]
          Length = 4935

 Score = 74.7 bits (182), Expect = 3e-13
 Identities = 50/153 (32%), Positives = 79/153 (51%), Gaps = 28/153 (18%)

Query: 44   VQGEIHLRLEVWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRV--------------- 88
            + GEI L++    G     L   +L+AR+L P+D NG SDPFV+V               
Sbjct: 4694 ITGEIQLQINYDLG----NLIIHILQARNLVPRDNNGYSDPFVKVYLLPGRGQVMVVQNA 4749

Query: 89   --RYKGRTRETSIVKKSCYPRWNETFEFE---LQEGAMEALCVEAWDWDLVSRNDFLGKV 143
               YK RT+    V+KS  P WN+T  ++   +++   + L V  WD+D  S NDFLG+V
Sbjct: 4750 SAEYKRRTKH---VQKSLNPEWNQTVIYKSISMEQLKKKTLEVTVWDYDRFSSNDFLGEV 4806

Query: 144  VIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGN 176
            +ID+     +     W+ L+ +Q++S  H + +
Sbjct: 4807 LIDLSSTSHLDNTPRWYPLK-EQTESIDHGKSH 4838


>gi|150378539 piccolo isoform 1 [Homo sapiens]
          Length = 5142

 Score = 74.7 bits (182), Expect = 3e-13
 Identities = 50/153 (32%), Positives = 79/153 (51%), Gaps = 28/153 (18%)

Query: 44   VQGEIHLRLEVWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRV--------------- 88
            + GEI L++    G     L   +L+AR+L P+D NG SDPFV+V               
Sbjct: 4694 ITGEIQLQINYDLG----NLIIHILQARNLVPRDNNGYSDPFVKVYLLPGRGQVMVVQNA 4749

Query: 89   --RYKGRTRETSIVKKSCYPRWNETFEFE---LQEGAMEALCVEAWDWDLVSRNDFLGKV 143
               YK RT+    V+KS  P WN+T  ++   +++   + L V  WD+D  S NDFLG+V
Sbjct: 4750 SAEYKRRTKH---VQKSLNPEWNQTVIYKSISMEQLKKKTLEVTVWDYDRFSSNDFLGEV 4806

Query: 144  VIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGN 176
            +ID+     +     W+ L+ +Q++S  H + +
Sbjct: 4807 LIDLSSTSHLDNTPRWYPLK-EQTESIDHGKSH 4838


>gi|50582996 multiple C2 domains, transmembrane 1 isoform S [Homo
           sapiens]
          Length = 778

 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 34/104 (32%), Positives = 58/104 (55%), Gaps = 4/104 (3%)

Query: 47  EIHLRLEVWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYP 106
           ++H +  +W G     +  +++E RDL   D NG SDP+V+ R   +  ++ I+ K+  P
Sbjct: 239 DLHRKSHLWRGI----VSITLIEGRDLKAMDSNGLSDPYVKFRLGHQKYKSKIMPKTLNP 294

Query: 107 RWNETFEFELQEGAMEALCVEAWDWDLVSRNDFLGKVVIDVQRL 150
           +W E F+F L E     + + AWD D   R+DF+G+  +D+  L
Sbjct: 295 QWREQFDFHLYEERGGVIDITAWDKDAGKRDDFIGRCQVDLSAL 338



 Score = 50.8 bits (120), Expect = 4e-06
 Identities = 38/139 (27%), Positives = 69/139 (49%), Gaps = 14/139 (10%)

Query: 62  RLRCSVLEARDLAPKDRNGTSDPFVRVRYKGR-TRETSIVKKSCYPRWNETFEFELQEGA 120
           +L  ++   + LA +DR GTSDP+V+ +  G+    + I+ K+  P W E     L +  
Sbjct: 41  QLDITLRRGQSLAARDRGGTSDPYVKFKIGGKEVFRSKIIHKNLNPVWEEK-ACILVDHL 99

Query: 121 MEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGNLGSL 180
            E L ++ +D+D   ++DF+G   +D+ +L + +  +    L     K   + + +LG +
Sbjct: 100 REPLYIKVFDYDFGLQDDFMGSAFLDLTQLELNRPTDVTLTL-----KDPHYPDHDLGII 154

Query: 181 QLEVRL-------RDETVL 192
            L V L       RD T+L
Sbjct: 155 LLSVILTPKEGESRDVTML 173



 Score = 47.8 bits (112), Expect = 4e-05
 Identities = 31/94 (32%), Positives = 44/94 (46%), Gaps = 1/94 (1%)

Query: 63  LRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEGAME 122
           L+  V+ A  L   D  G SDPF  V        T  V K+  P WN+ F F +++    
Sbjct: 407 LQVKVIRAEGLMAADVTGKSDPFCVVELNNDRLLTHTVYKNLNPEWNKVFTFNIKD-IHS 465

Query: 123 ALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQE 156
            L V  +D D     DFLGKV I +  ++  +Q+
Sbjct: 466 VLEVTVYDEDRDRSADFLGKVAIPLLSIQNGEQK 499


>gi|205361109 multiple C2 domains, transmembrane 1 isoform L [Homo
           sapiens]
          Length = 999

 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 34/104 (32%), Positives = 58/104 (55%), Gaps = 4/104 (3%)

Query: 47  EIHLRLEVWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYP 106
           ++H +  +W G     +  +++E RDL   D NG SDP+V+ R   +  ++ I+ K+  P
Sbjct: 460 DLHRKSHLWRGI----VSITLIEGRDLKAMDSNGLSDPYVKFRLGHQKYKSKIMPKTLNP 515

Query: 107 RWNETFEFELQEGAMEALCVEAWDWDLVSRNDFLGKVVIDVQRL 150
           +W E F+F L E     + + AWD D   R+DF+G+  +D+  L
Sbjct: 516 QWREQFDFHLYEERGGVIDITAWDKDAGKRDDFIGRCQVDLSAL 559



 Score = 50.8 bits (120), Expect = 4e-06
 Identities = 38/139 (27%), Positives = 69/139 (49%), Gaps = 14/139 (10%)

Query: 62  RLRCSVLEARDLAPKDRNGTSDPFVRVRYKGR-TRETSIVKKSCYPRWNETFEFELQEGA 120
           +L  ++   + LA +DR GTSDP+V+ +  G+    + I+ K+  P W E     L +  
Sbjct: 262 QLDITLRRGQSLAARDRGGTSDPYVKFKIGGKEVFRSKIIHKNLNPVWEEK-ACILVDHL 320

Query: 121 MEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGNLGSL 180
            E L ++ +D+D   ++DF+G   +D+ +L + +  +    L     K   + + +LG +
Sbjct: 321 REPLYIKVFDYDFGLQDDFMGSAFLDLTQLELNRPTDVTLTL-----KDPHYPDHDLGII 375

Query: 181 QLEVRL-------RDETVL 192
            L V L       RD T+L
Sbjct: 376 LLSVILTPKEGESRDVTML 394



 Score = 47.8 bits (112), Expect = 4e-05
 Identities = 31/94 (32%), Positives = 44/94 (46%), Gaps = 1/94 (1%)

Query: 63  LRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEGAME 122
           L+  V+ A  L   D  G SDPF  V        T  V K+  P WN+ F F +++    
Sbjct: 628 LQVKVIRAEGLMAADVTGKSDPFCVVELNNDRLLTHTVYKNLNPEWNKVFTFNIKD-IHS 686

Query: 123 ALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQE 156
            L V  +D D     DFLGKV I +  ++  +Q+
Sbjct: 687 VLEVTVYDEDRDRSADFLGKVAIPLLSIQNGEQK 720


>gi|38570146 synaptotagmin VII [Homo sapiens]
          Length = 403

 Score = 70.5 bits (171), Expect = 5e-12
 Identities = 42/116 (36%), Positives = 66/116 (56%), Gaps = 8/116 (6%)

Query: 63  LRCSVLEARDLAPKDRNGTSDPFVRVRY---KGRTRETSIVKKSCYPRWNETFEFE---L 116
           L   +++A++L  KD +GTSDPFV++     K    ET + +K+  P WNETF FE    
Sbjct: 152 LTVKIMKAQELPAKDFSGTSDPFVKIYLLPDKKHKLETKVKRKNLNPHWNETFLFEGFPY 211

Query: 117 QEGAMEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQP--DQSKSR 170
           ++     L ++  D+D  SRND +G+V I + ++ + Q +  W  L+P  D S SR
Sbjct: 212 EKVVQRILYLQVLDYDRFSRNDPIGEVSIPLNKVDLTQMQTFWKDLKPCSDGSGSR 267



 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 45/153 (29%), Positives = 81/153 (52%), Gaps = 12/153 (7%)

Query: 1   MDEDALSRDDVIGKVCLTRDTI-ASHPKGFSGWAHLTEVDPDEEVQGEIHLRLEVWPGAR 59
           +D D  SR+D IG+V +  + +  +  + F  W  L         +GE+ L L   P A 
Sbjct: 224 LDYDRFSRNDPIGEVSIPLNKVDLTQMQTF--WKDLKPCSDGSGSRGELLLSLCYNPSAN 281

Query: 60  ACRLRCSVLEARDLAPKDRNGTSDPFVRV--RYKGR---TRETSIVKKSCYPRWNETFEF 114
           +  +  ++++AR+L   D  GTSDP+V+V   YK +    ++T  +K++  P +NE+F F
Sbjct: 282 S--IIVNIIKARNLKAMDIGGTSDPYVKVWLMYKDKRVEKKKTVTMKRNLNPIFNESFAF 339

Query: 115 ELQEGAME--ALCVEAWDWDLVSRNDFLGKVVI 145
           ++    +    + +   D D +SRND +GK+ +
Sbjct: 340 DIPTEKLRETTIIITVMDKDKLSRNDVIGKIYL 372


>gi|109826564 neurofibromin isoform 1 [Homo sapiens]
          Length = 2839

 Score = 68.6 bits (166), Expect = 2e-11
 Identities = 68/269 (25%), Positives = 115/269 (42%), Gaps = 32/269 (11%)

Query: 189  ETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVATNLLKLFLGQGLA 248
            ETVL +  ++ LV L+     +G QG   +   +          ++A  L+ LF  + L 
Sbjct: 1198 ETVL-ADRFERLVELV---TMMGDQGELPIAMALANVVPCSQWDELARVLVTLFDSRHLL 1253

Query: 249  KDFLDLLFQLELSRTSETNTLFRSNSLASKSVESFLKVAGMQYLHGVLGPIINKVFEEKK 308
               L  +F  E+       TLFR NSLASK +    KV G  YL  +L P++  V     
Sbjct: 1254 YQLLWNMFSKEVELADSMQTLFRGNSLASKIMTFCFKVYGATYLQKLLDPLLRIVITSSD 1313

Query: 309  Y----VELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSALSRSVRACPA 364
            +     E+DP+++E  +         + +  +L+ + +   A + +      +    C  
Sbjct: 1314 WQHVSFEVDPTRLEPSE------SLEENQRNLLQMTEKFFHAIISSSSEFPPQLRSVCHC 1367

Query: 365  VVRATFRQLFRR-------------VRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPK 411
            + +AT   L  +             V +RFP          AV S + LRF +PAI+SP 
Sbjct: 1368 LYQATCHSLLNKATVKEKKENKKSVVSQRFP-----QNSIGAVGSAMFLRFINPAIVSPY 1422

Query: 412  LFHLRERHADARTSRTLLLLAKAVQNVGN 440
               + ++    R  R L L++K +Q++ N
Sbjct: 1423 EAGILDKKPPPRIERGLKLMSKILQSIAN 1451


>gi|47078261 double C2-like domains, alpha [Homo sapiens]
          Length = 400

 Score = 64.3 bits (155), Expect = 4e-10
 Identities = 58/204 (28%), Positives = 85/204 (41%), Gaps = 33/204 (16%)

Query: 2   DEDALSRDDVIGKV-----------------CLTRDTIASHPKGFSGW-----AHLTEVD 39
           DED LS ++ IG++                 CL R    + P   S        +L E++
Sbjct: 181 DEDKLSHNEFIGEIRVPLRRLKPSQKKHFNICLERQVPLASPSSMSAALRGISCYLKELE 240

Query: 40  PDEEVQGEIHLR----LEVWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRY----- 90
             E+ QG +  R    L +   +R   L   +L    LA  D NG SDP+V+        
Sbjct: 241 QAEQGQGLLEERGRILLSLSYSSRRRGLLVGILRCAHLAAMDVNGYSDPYVKTYLRPDVD 300

Query: 91  KGRTRETSIVKKSCYPRWNETF--EFELQEGAMEALCVEAWDWDLVSRNDFLGKVVIDVQ 148
           K    +T + KK+  P +NE F  E EL   A + L V  WD+D+   NDF+G V +   
Sbjct: 301 KKSKHKTCVKKKTLNPEFNEEFFYEIELSTLATKTLEVTVWDYDIGKSNDFIGGVSLGPG 360

Query: 149 RLRVVQQEEGWFRLQPDQSKSRRH 172
                ++       QPD +  R H
Sbjct: 361 ARGEARKHWSDCLQQPDAALERWH 384



 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 30/105 (28%), Positives = 55/105 (52%), Gaps = 8/105 (7%)

Query: 60  ACRLRCSVLEARDLAPKDRNGTSDPFVRVRY-----KGRTRETSIVKKSCYPRWNETFEF 114
           +C L CS+L A+ L P D NG +DP+V++       K    +T   + +  P WNE   +
Sbjct: 103 SCTLHCSILRAKGLKPMDFNGLADPYVKLHLLPGACKANKLKTKTQRNTLNPVWNEDLTY 162

Query: 115 E---LQEGAMEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQE 156
                 +   + L +   D D +S N+F+G++ + ++RL+  Q++
Sbjct: 163 SGITDDDITHKVLRIAVCDEDKLSHNEFIGEIRVPLRRLKPSQKK 207


>gi|40068038 B/K protein [Homo sapiens]
          Length = 474

 Score = 64.3 bits (155), Expect = 4e-10
 Identities = 48/152 (31%), Positives = 78/152 (51%), Gaps = 10/152 (6%)

Query: 1   MDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEIHLRLEVWPGARA 60
           +D D  SR  VIGKV +    +    KG   W  L     +E   GE+ L L   P A  
Sbjct: 279 VDFDKFSRHCVIGKVSVPLCEV-DLVKGGHWWKALIPSSQNEVELGELLLSLNYLPSAG- 336

Query: 61  CRLRCSVLEARDLAPKDRNGTSDPFVRVRYKG-----RTRETSIVKKSCYPRWNETFEFE 115
            RL   V+ A+ L   D +  SDPFV+++        +T++TS ++ +  P +NE+F F+
Sbjct: 337 -RLNVDVIRAKQLLQTDVSQGSDPFVKIQLVHGLKLVKTKKTSFLRGTIDPFYNESFSFK 395

Query: 116 LQEGAME--ALCVEAWDWDLVSRNDFLGKVVI 145
           + +  +E  +L    +  ++ S NDF+G++VI
Sbjct: 396 VPQEELENASLVFTVFGHNMKSSNDFIGRIVI 427



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 36/134 (26%), Positives = 64/134 (47%), Gaps = 17/134 (12%)

Query: 63  LRCSVLEARDLAPK-DRNGT------SDPFVRVRY---KGRTRETSIVKKSCYPRWNETF 112
           L   V+EARDL P    +G+      S+P+V++     +  +++T + +K+  P + E +
Sbjct: 201 LTVRVIEARDLPPPISHDGSRQDMAHSNPYVKICLLPDQKNSKQTGVKRKTQKPVFEERY 260

Query: 113 EFELQ--EGAMEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSR 170
            FE+   E     L +   D+D  SR+  +GKV + +  + +V+    W  L P      
Sbjct: 261 TFEIPFLEAQRRTLLLTVVDFDKFSRHCVIGKVSVPLCEVDLVKGGHWWKALIPSS---- 316

Query: 171 RHDEGNLGSLQLEV 184
             +E  LG L L +
Sbjct: 317 -QNEVELGELLLSL 329


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.134    0.399 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,385,294
Number of Sequences: 37866
Number of extensions: 1284213
Number of successful extensions: 3901
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 90
Number of HSP's successfully gapped in prelim test: 84
Number of HSP's that attempted gapping in prelim test: 3396
Number of HSP's gapped (non-prelim): 375
length of query: 731
length of database: 18,247,518
effective HSP length: 110
effective length of query: 621
effective length of database: 14,082,258
effective search space: 8745082218
effective search space used: 8745082218
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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