BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|239508992 PREDICTED: similar to calcium-promoted Ras inactivator isoform 1 [Homo sapiens] (731 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|239743309 PREDICTED: similar to calcium-promoted Ras inactiva... 1467 0.0 gi|239508992 PREDICTED: similar to calcium-promoted Ras inactiva... 1467 0.0 gi|121114294 RAS p21 protein activator 4 isoform 1 [Homo sapiens] 1460 0.0 gi|239743307 PREDICTED: similar to calcium-promoted Ras inactiva... 1356 0.0 gi|239508990 PREDICTED: similar to calcium-promoted Ras inactiva... 1356 0.0 gi|121114292 RAS p21 protein activator 4 isoform 2 [Homo sapiens] 1348 0.0 gi|4759026 RAS protein activator like 1 [Homo sapiens] 620 e-177 gi|12545408 RAS p21 protein activator 2 [Homo sapiens] 293 3e-79 gi|38201692 RAS p21 protein activator 3 [Homo sapiens] 283 3e-76 gi|226958575 RAS protein activator like 2 isoform 2 [Homo sapiens] 132 9e-31 gi|4758808 RAS protein activator like 2 isoform 1 [Homo sapiens] 132 9e-31 gi|41281683 disabled homolog 2 interacting protein isoform 2 [Ho... 118 2e-26 gi|94967023 disabled homolog 2 interacting protein isoform 1 [Ho... 118 2e-26 gi|194248068 synaptic Ras GTPase activating protein 1 [Homo sapi... 115 1e-25 gi|4506431 RAS p21 protein activator 1 isoform 1 [Homo sapiens] 105 1e-22 gi|12545406 RAS p21 protein activator 1 isoform 2 [Homo sapiens] 105 1e-22 gi|130502162 RAS protein activator like 3 [Homo sapiens] 87 5e-17 gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens] 84 5e-16 gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens] 84 5e-16 gi|13384594 protein kinase C, gamma [Homo sapiens] 81 3e-15 gi|4506067 protein kinase C, alpha [Homo sapiens] 79 1e-14 gi|4557793 neurofibromin isoform 2 [Homo sapiens] 77 6e-14 gi|150170670 piccolo isoform 2 [Homo sapiens] 75 3e-13 gi|150378539 piccolo isoform 1 [Homo sapiens] 75 3e-13 gi|50582996 multiple C2 domains, transmembrane 1 isoform S [Homo... 72 2e-12 gi|205361109 multiple C2 domains, transmembrane 1 isoform L [Hom... 72 2e-12 gi|38570146 synaptotagmin VII [Homo sapiens] 70 5e-12 gi|109826564 neurofibromin isoform 1 [Homo sapiens] 69 2e-11 gi|47078261 double C2-like domains, alpha [Homo sapiens] 64 4e-10 gi|40068038 B/K protein [Homo sapiens] 64 4e-10 >gi|239743309 PREDICTED: similar to calcium-promoted Ras inactivator isoform 2 [Homo sapiens] Length = 731 Score = 1467 bits (3799), Expect = 0.0 Identities = 731/731 (100%), Positives = 731/731 (100%) Query: 1 MDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEIHLRLEVWPGARA 60 MDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEIHLRLEVWPGARA Sbjct: 1 MDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEIHLRLEVWPGARA 60 Query: 61 CRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEGA 120 CRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEGA Sbjct: 61 CRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEGA 120 Query: 121 MEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGNLGSL 180 MEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGNLGSL Sbjct: 121 MEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGNLGSL 180 Query: 181 QLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVATNLLK 240 QLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVATNLLK Sbjct: 181 QLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVATNLLK 240 Query: 241 LFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSVESFLKVAGMQYLHGVLGPII 300 LFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSVESFLKVAGMQYLHGVLGPII Sbjct: 241 LFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSVESFLKVAGMQYLHGVLGPII 300 Query: 301 NKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSALSRSVR 360 NKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSALSRSVR Sbjct: 301 NKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSALSRSVR 360 Query: 361 ACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFHLRERHA 420 ACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFHLRERHA Sbjct: 361 ACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFHLRERHA 420 Query: 421 DARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVHQGVAQLKDFITKLVDIEEK 480 DARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVHQGVAQLKDFITKLVDIEEK Sbjct: 421 DARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVHQGVAQLKDFITKLVDIEEK 480 Query: 481 DELDLQRTLSLQAPPVKEGPLFIHRTKGKGPLMSSSFKKLYFSLTTEALSFAKTPSSKKS 540 DELDLQRTLSLQAPPVKEGPLFIHRTKGKGPLMSSSFKKLYFSLTTEALSFAKTPSSKKS Sbjct: 481 DELDLQRTLSLQAPPVKEGPLFIHRTKGKGPLMSSSFKKLYFSLTTEALSFAKTPSSKKS 540 Query: 541 ALIKLANIRAAEKVEEKSFGGSHVMQVIYTDDAGRPQTAYLQCKCVNELNQWLSALRKVS 600 ALIKLANIRAAEKVEEKSFGGSHVMQVIYTDDAGRPQTAYLQCKCVNELNQWLSALRKVS Sbjct: 541 ALIKLANIRAAEKVEEKSFGGSHVMQVIYTDDAGRPQTAYLQCKCVNELNQWLSALRKVS 600 Query: 601 INNTGLLGSYHPGVFRGDKWSCCHQKEKTGQGCDKTRSRVTLQEWNDPLDHDLEAQLIYR 660 INNTGLLGSYHPGVFRGDKWSCCHQKEKTGQGCDKTRSRVTLQEWNDPLDHDLEAQLIYR Sbjct: 601 INNTGLLGSYHPGVFRGDKWSCCHQKEKTGQGCDKTRSRVTLQEWNDPLDHDLEAQLIYR 660 Query: 661 HLLGVEAMLWERHRELSGGAEAGTVPTSPGKVPEDSLARLLRVLQDLREAHSSSPAGSPP 720 HLLGVEAMLWERHRELSGGAEAGTVPTSPGKVPEDSLARLLRVLQDLREAHSSSPAGSPP Sbjct: 661 HLLGVEAMLWERHRELSGGAEAGTVPTSPGKVPEDSLARLLRVLQDLREAHSSSPAGSPP 720 Query: 721 SEPNCLLELQT 731 SEPNCLLELQT Sbjct: 721 SEPNCLLELQT 731 >gi|239508992 PREDICTED: similar to calcium-promoted Ras inactivator isoform 1 [Homo sapiens] Length = 731 Score = 1467 bits (3799), Expect = 0.0 Identities = 731/731 (100%), Positives = 731/731 (100%) Query: 1 MDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEIHLRLEVWPGARA 60 MDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEIHLRLEVWPGARA Sbjct: 1 MDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEIHLRLEVWPGARA 60 Query: 61 CRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEGA 120 CRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEGA Sbjct: 61 CRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEGA 120 Query: 121 MEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGNLGSL 180 MEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGNLGSL Sbjct: 121 MEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGNLGSL 180 Query: 181 QLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVATNLLK 240 QLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVATNLLK Sbjct: 181 QLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVATNLLK 240 Query: 241 LFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSVESFLKVAGMQYLHGVLGPII 300 LFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSVESFLKVAGMQYLHGVLGPII Sbjct: 241 LFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSVESFLKVAGMQYLHGVLGPII 300 Query: 301 NKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSALSRSVR 360 NKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSALSRSVR Sbjct: 301 NKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSALSRSVR 360 Query: 361 ACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFHLRERHA 420 ACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFHLRERHA Sbjct: 361 ACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFHLRERHA 420 Query: 421 DARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVHQGVAQLKDFITKLVDIEEK 480 DARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVHQGVAQLKDFITKLVDIEEK Sbjct: 421 DARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVHQGVAQLKDFITKLVDIEEK 480 Query: 481 DELDLQRTLSLQAPPVKEGPLFIHRTKGKGPLMSSSFKKLYFSLTTEALSFAKTPSSKKS 540 DELDLQRTLSLQAPPVKEGPLFIHRTKGKGPLMSSSFKKLYFSLTTEALSFAKTPSSKKS Sbjct: 481 DELDLQRTLSLQAPPVKEGPLFIHRTKGKGPLMSSSFKKLYFSLTTEALSFAKTPSSKKS 540 Query: 541 ALIKLANIRAAEKVEEKSFGGSHVMQVIYTDDAGRPQTAYLQCKCVNELNQWLSALRKVS 600 ALIKLANIRAAEKVEEKSFGGSHVMQVIYTDDAGRPQTAYLQCKCVNELNQWLSALRKVS Sbjct: 541 ALIKLANIRAAEKVEEKSFGGSHVMQVIYTDDAGRPQTAYLQCKCVNELNQWLSALRKVS 600 Query: 601 INNTGLLGSYHPGVFRGDKWSCCHQKEKTGQGCDKTRSRVTLQEWNDPLDHDLEAQLIYR 660 INNTGLLGSYHPGVFRGDKWSCCHQKEKTGQGCDKTRSRVTLQEWNDPLDHDLEAQLIYR Sbjct: 601 INNTGLLGSYHPGVFRGDKWSCCHQKEKTGQGCDKTRSRVTLQEWNDPLDHDLEAQLIYR 660 Query: 661 HLLGVEAMLWERHRELSGGAEAGTVPTSPGKVPEDSLARLLRVLQDLREAHSSSPAGSPP 720 HLLGVEAMLWERHRELSGGAEAGTVPTSPGKVPEDSLARLLRVLQDLREAHSSSPAGSPP Sbjct: 661 HLLGVEAMLWERHRELSGGAEAGTVPTSPGKVPEDSLARLLRVLQDLREAHSSSPAGSPP 720 Query: 721 SEPNCLLELQT 731 SEPNCLLELQT Sbjct: 721 SEPNCLLELQT 731 >gi|121114294 RAS p21 protein activator 4 isoform 1 [Homo sapiens] Length = 803 Score = 1460 bits (3779), Expect = 0.0 Identities = 728/731 (99%), Positives = 729/731 (99%) Query: 1 MDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEIHLRLEVWPGARA 60 MDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEIHLRLEVWPGARA Sbjct: 73 MDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEIHLRLEVWPGARA 132 Query: 61 CRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEGA 120 CRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEGA Sbjct: 133 CRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEGA 192 Query: 121 MEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGNLGSL 180 MEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGNLGSL Sbjct: 193 MEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGNLGSL 252 Query: 181 QLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVATNLLK 240 QLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVATNLLK Sbjct: 253 QLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVATNLLK 312 Query: 241 LFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSVESFLKVAGMQYLHGVLGPII 300 LFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKS+ESFLKVAGMQYLHGVLGPII Sbjct: 313 LFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSMESFLKVAGMQYLHGVLGPII 372 Query: 301 NKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSALSRSVR 360 NKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSALSRSVR Sbjct: 373 NKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSALSRSVR 432 Query: 361 ACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFHLRERHA 420 ACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFHLRERHA Sbjct: 433 ACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFHLRERHA 492 Query: 421 DARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVHQGVAQLKDFITKLVDIEEK 480 DARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTV QGVAQLKDFITKLVDIEEK Sbjct: 493 DARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVRQGVAQLKDFITKLVDIEEK 552 Query: 481 DELDLQRTLSLQAPPVKEGPLFIHRTKGKGPLMSSSFKKLYFSLTTEALSFAKTPSSKKS 540 DELDLQRTLSLQAPPVKEGPLFIHRTKGKGPLMSSSFKKLYFSLTTEALSFAKTPSSKKS Sbjct: 553 DELDLQRTLSLQAPPVKEGPLFIHRTKGKGPLMSSSFKKLYFSLTTEALSFAKTPSSKKS 612 Query: 541 ALIKLANIRAAEKVEEKSFGGSHVMQVIYTDDAGRPQTAYLQCKCVNELNQWLSALRKVS 600 ALIKLANIRAAEKVEEKSFGGSHVMQVIYTDDAGRPQTAYLQCKCVNELNQWLSALRKVS Sbjct: 613 ALIKLANIRAAEKVEEKSFGGSHVMQVIYTDDAGRPQTAYLQCKCVNELNQWLSALRKVS 672 Query: 601 INNTGLLGSYHPGVFRGDKWSCCHQKEKTGQGCDKTRSRVTLQEWNDPLDHDLEAQLIYR 660 INNTGLLGSYHPGVFRGDKWSCCHQKEKTGQGCDKTRSRVTLQEWNDPLDHDLEAQLI R Sbjct: 673 INNTGLLGSYHPGVFRGDKWSCCHQKEKTGQGCDKTRSRVTLQEWNDPLDHDLEAQLICR 732 Query: 661 HLLGVEAMLWERHRELSGGAEAGTVPTSPGKVPEDSLARLLRVLQDLREAHSSSPAGSPP 720 HLLGVEAMLWERHRELSGGAEAGTVPTSPGKVPEDSLARLLRVLQDLREAHSSSPAGSPP Sbjct: 733 HLLGVEAMLWERHRELSGGAEAGTVPTSPGKVPEDSLARLLRVLQDLREAHSSSPAGSPP 792 Query: 721 SEPNCLLELQT 731 SEPNCLLELQT Sbjct: 793 SEPNCLLELQT 803 Score = 43.5 bits (101), Expect = 7e-04 Identities = 27/89 (30%), Positives = 44/89 (49%), Gaps = 2/89 (2%) Query: 58 ARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGR-TRETSIVKKSCYPRWNETFEFEL 116 A+ L ++E ++L KD G+SDP+ V+ T+ V K+ P W E ++ L Sbjct: 2 AKRSSLYIRIVEGKNLPAKDITGSSDPYCIVKVDNEPIIRTATVWKTLCPFWGEEYQVHL 61 Query: 117 QEGAMEALCVEAWDWDLVSRNDFLGKVVI 145 A+ D D +SR+D +GKV + Sbjct: 62 PP-TFHAVAFYVMDEDALSRDDVIGKVCL 89 >gi|239743307 PREDICTED: similar to calcium-promoted Ras inactivator isoform 1 [Homo sapiens] Length = 757 Score = 1356 bits (3510), Expect = 0.0 Identities = 685/731 (93%), Positives = 685/731 (93%), Gaps = 46/731 (6%) Query: 1 MDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEIHLRLEVWPGARA 60 MDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEIHLRLEVWPGARA Sbjct: 73 MDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEIHLRLEVWPGARA 132 Query: 61 CRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEGA 120 CRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEGA Sbjct: 133 CRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEGA 192 Query: 121 MEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGNLGSL 180 MEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGNLGSL Sbjct: 193 MEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGNLGSL 252 Query: 181 QLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVATNLLK 240 QLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVATNLLK Sbjct: 253 QLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVATNLLK 312 Query: 241 LFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSVESFLKVAGMQYLHGVLGPII 300 LFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSVESFLKVAGMQYLHGVLGPII Sbjct: 313 LFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSVESFLKVAGMQYLHGVLGPII 372 Query: 301 NKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSALSRSVR 360 NKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSALSRSVR Sbjct: 373 NKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSALSRSVR 432 Query: 361 ACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFHLRERHA 420 ACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFHLRERHA Sbjct: 433 ACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFHLRERHA 492 Query: 421 DARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVHQGVAQLKDFITKLVDIEEK 480 DARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVHQGVAQLKDFITKLVDIEEK Sbjct: 493 DARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVHQGVAQLKDFITKLVDIEEK 552 Query: 481 DELDLQRTLSLQAPPVKEGPLFIHRTKGKGPLMSSSFKKLYFSLTTEALSFAKTPSSKKS 540 DELDLQRTLSLQAPPVKEGPLFIHRTKGKGPLMSSSFKKLYFSLTTEALSFAKTPSS Sbjct: 553 DELDLQRTLSLQAPPVKEGPLFIHRTKGKGPLMSSSFKKLYFSLTTEALSFAKTPSS--- 609 Query: 541 ALIKLANIRAAEKVEEKSFGGSHVMQVIYTDDAGRPQTAYLQCKCVNELNQWLSALRKVS 600 KCVNELNQWLSALRKVS Sbjct: 610 -------------------------------------------KCVNELNQWLSALRKVS 626 Query: 601 INNTGLLGSYHPGVFRGDKWSCCHQKEKTGQGCDKTRSRVTLQEWNDPLDHDLEAQLIYR 660 INNTGLLGSYHPGVFRGDKWSCCHQKEKTGQGCDKTRSRVTLQEWNDPLDHDLEAQLIYR Sbjct: 627 INNTGLLGSYHPGVFRGDKWSCCHQKEKTGQGCDKTRSRVTLQEWNDPLDHDLEAQLIYR 686 Query: 661 HLLGVEAMLWERHRELSGGAEAGTVPTSPGKVPEDSLARLLRVLQDLREAHSSSPAGSPP 720 HLLGVEAMLWERHRELSGGAEAGTVPTSPGKVPEDSLARLLRVLQDLREAHSSSPAGSPP Sbjct: 687 HLLGVEAMLWERHRELSGGAEAGTVPTSPGKVPEDSLARLLRVLQDLREAHSSSPAGSPP 746 Query: 721 SEPNCLLELQT 731 SEPNCLLELQT Sbjct: 747 SEPNCLLELQT 757 Score = 43.5 bits (101), Expect = 7e-04 Identities = 27/89 (30%), Positives = 44/89 (49%), Gaps = 2/89 (2%) Query: 58 ARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGR-TRETSIVKKSCYPRWNETFEFEL 116 A+ L ++E ++L KD G+SDP+ V+ T+ V K+ P W E ++ L Sbjct: 2 AKRSSLYIRIVEGKNLPAKDITGSSDPYCIVKVDNEPIIRTATVWKTLCPFWGEEYQVHL 61 Query: 117 QEGAMEALCVEAWDWDLVSRNDFLGKVVI 145 A+ D D +SR+D +GKV + Sbjct: 62 PP-TFHAVAFYVMDEDALSRDDVIGKVCL 89 >gi|239508990 PREDICTED: similar to calcium-promoted Ras inactivator isoform 2 [Homo sapiens] Length = 757 Score = 1356 bits (3510), Expect = 0.0 Identities = 685/731 (93%), Positives = 685/731 (93%), Gaps = 46/731 (6%) Query: 1 MDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEIHLRLEVWPGARA 60 MDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEIHLRLEVWPGARA Sbjct: 73 MDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEIHLRLEVWPGARA 132 Query: 61 CRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEGA 120 CRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEGA Sbjct: 133 CRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEGA 192 Query: 121 MEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGNLGSL 180 MEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGNLGSL Sbjct: 193 MEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGNLGSL 252 Query: 181 QLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVATNLLK 240 QLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVATNLLK Sbjct: 253 QLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVATNLLK 312 Query: 241 LFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSVESFLKVAGMQYLHGVLGPII 300 LFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSVESFLKVAGMQYLHGVLGPII Sbjct: 313 LFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSVESFLKVAGMQYLHGVLGPII 372 Query: 301 NKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSALSRSVR 360 NKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSALSRSVR Sbjct: 373 NKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSALSRSVR 432 Query: 361 ACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFHLRERHA 420 ACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFHLRERHA Sbjct: 433 ACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFHLRERHA 492 Query: 421 DARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVHQGVAQLKDFITKLVDIEEK 480 DARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVHQGVAQLKDFITKLVDIEEK Sbjct: 493 DARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVHQGVAQLKDFITKLVDIEEK 552 Query: 481 DELDLQRTLSLQAPPVKEGPLFIHRTKGKGPLMSSSFKKLYFSLTTEALSFAKTPSSKKS 540 DELDLQRTLSLQAPPVKEGPLFIHRTKGKGPLMSSSFKKLYFSLTTEALSFAKTPSS Sbjct: 553 DELDLQRTLSLQAPPVKEGPLFIHRTKGKGPLMSSSFKKLYFSLTTEALSFAKTPSS--- 609 Query: 541 ALIKLANIRAAEKVEEKSFGGSHVMQVIYTDDAGRPQTAYLQCKCVNELNQWLSALRKVS 600 KCVNELNQWLSALRKVS Sbjct: 610 -------------------------------------------KCVNELNQWLSALRKVS 626 Query: 601 INNTGLLGSYHPGVFRGDKWSCCHQKEKTGQGCDKTRSRVTLQEWNDPLDHDLEAQLIYR 660 INNTGLLGSYHPGVFRGDKWSCCHQKEKTGQGCDKTRSRVTLQEWNDPLDHDLEAQLIYR Sbjct: 627 INNTGLLGSYHPGVFRGDKWSCCHQKEKTGQGCDKTRSRVTLQEWNDPLDHDLEAQLIYR 686 Query: 661 HLLGVEAMLWERHRELSGGAEAGTVPTSPGKVPEDSLARLLRVLQDLREAHSSSPAGSPP 720 HLLGVEAMLWERHRELSGGAEAGTVPTSPGKVPEDSLARLLRVLQDLREAHSSSPAGSPP Sbjct: 687 HLLGVEAMLWERHRELSGGAEAGTVPTSPGKVPEDSLARLLRVLQDLREAHSSSPAGSPP 746 Query: 721 SEPNCLLELQT 731 SEPNCLLELQT Sbjct: 747 SEPNCLLELQT 757 Score = 43.5 bits (101), Expect = 7e-04 Identities = 27/89 (30%), Positives = 44/89 (49%), Gaps = 2/89 (2%) Query: 58 ARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGR-TRETSIVKKSCYPRWNETFEFEL 116 A+ L ++E ++L KD G+SDP+ V+ T+ V K+ P W E ++ L Sbjct: 2 AKRSSLYIRIVEGKNLPAKDITGSSDPYCIVKVDNEPIIRTATVWKTLCPFWGEEYQVHL 61 Query: 117 QEGAMEALCVEAWDWDLVSRNDFLGKVVI 145 A+ D D +SR+D +GKV + Sbjct: 62 PP-TFHAVAFYVMDEDALSRDDVIGKVCL 89 >gi|121114292 RAS p21 protein activator 4 isoform 2 [Homo sapiens] Length = 757 Score = 1348 bits (3490), Expect = 0.0 Identities = 682/731 (93%), Positives = 683/731 (93%), Gaps = 46/731 (6%) Query: 1 MDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEIHLRLEVWPGARA 60 MDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEIHLRLEVWPGARA Sbjct: 73 MDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEIHLRLEVWPGARA 132 Query: 61 CRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEGA 120 CRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEGA Sbjct: 133 CRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEGA 192 Query: 121 MEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGNLGSL 180 MEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGNLGSL Sbjct: 193 MEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGNLGSL 252 Query: 181 QLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVATNLLK 240 QLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVATNLLK Sbjct: 253 QLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVATNLLK 312 Query: 241 LFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSVESFLKVAGMQYLHGVLGPII 300 LFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKS+ESFLKVAGMQYLHGVLGPII Sbjct: 313 LFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSMESFLKVAGMQYLHGVLGPII 372 Query: 301 NKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSALSRSVR 360 NKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSALSRSVR Sbjct: 373 NKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSALSRSVR 432 Query: 361 ACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFHLRERHA 420 ACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFHLRERHA Sbjct: 433 ACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFHLRERHA 492 Query: 421 DARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVHQGVAQLKDFITKLVDIEEK 480 DARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTV QGVAQLKDFITKLVDIEEK Sbjct: 493 DARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVRQGVAQLKDFITKLVDIEEK 552 Query: 481 DELDLQRTLSLQAPPVKEGPLFIHRTKGKGPLMSSSFKKLYFSLTTEALSFAKTPSSKKS 540 DELDLQRTLSLQAPPVKEGPLFIHRTKGKGPLMSSSFKKLYFSLTTEALSFAKTPSS Sbjct: 553 DELDLQRTLSLQAPPVKEGPLFIHRTKGKGPLMSSSFKKLYFSLTTEALSFAKTPSS--- 609 Query: 541 ALIKLANIRAAEKVEEKSFGGSHVMQVIYTDDAGRPQTAYLQCKCVNELNQWLSALRKVS 600 KCVNELNQWLSALRKVS Sbjct: 610 -------------------------------------------KCVNELNQWLSALRKVS 626 Query: 601 INNTGLLGSYHPGVFRGDKWSCCHQKEKTGQGCDKTRSRVTLQEWNDPLDHDLEAQLIYR 660 INNTGLLGSYHPGVFRGDKWSCCHQKEKTGQGCDKTRSRVTLQEWNDPLDHDLEAQLI R Sbjct: 627 INNTGLLGSYHPGVFRGDKWSCCHQKEKTGQGCDKTRSRVTLQEWNDPLDHDLEAQLICR 686 Query: 661 HLLGVEAMLWERHRELSGGAEAGTVPTSPGKVPEDSLARLLRVLQDLREAHSSSPAGSPP 720 HLLGVEAMLWERHRELSGGAEAGTVPTSPGKVPEDSLARLLRVLQDLREAHSSSPAGSPP Sbjct: 687 HLLGVEAMLWERHRELSGGAEAGTVPTSPGKVPEDSLARLLRVLQDLREAHSSSPAGSPP 746 Query: 721 SEPNCLLELQT 731 SEPNCLLELQT Sbjct: 747 SEPNCLLELQT 757 Score = 43.5 bits (101), Expect = 7e-04 Identities = 27/89 (30%), Positives = 44/89 (49%), Gaps = 2/89 (2%) Query: 58 ARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGR-TRETSIVKKSCYPRWNETFEFEL 116 A+ L ++E ++L KD G+SDP+ V+ T+ V K+ P W E ++ L Sbjct: 2 AKRSSLYIRIVEGKNLPAKDITGSSDPYCIVKVDNEPIIRTATVWKTLCPFWGEEYQVHL 61 Query: 117 QEGAMEALCVEAWDWDLVSRNDFLGKVVI 145 A+ D D +SR+D +GKV + Sbjct: 62 PP-TFHAVAFYVMDEDALSRDDVIGKVCL 89 >gi|4759026 RAS protein activator like 1 [Homo sapiens] Length = 804 Score = 620 bits (1599), Expect = e-177 Identities = 337/722 (46%), Positives = 461/722 (63%), Gaps = 19/722 (2%) Query: 1 MDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEIHLRLEVWPGARA 60 +DED + DD+IGK+ L+R+ I + P+G W +L+ VDPD EVQGEI L +++ + Sbjct: 73 LDEDTVGHDDIIGKISLSREAITADPRGIDSWINLSRVDPDAEVQGEICLSVQMLEDGQG 132 Query: 61 CRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEGA 120 LRC VL ARDLAP+D +GTSDPF RV + ++ ETS +KK+ +P W+E E GA Sbjct: 133 RCLRCHVLHARDLAPRDISGTSDPFARVFWGSQSLETSTIKKTRFPHWDEVLELREMPGA 192 Query: 121 MEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGNLGSL 180 L VE WDWD+V +NDFLG V + L+ + +GWFRL P ++ GNLG+L Sbjct: 193 PSPLRVELWDWDMVGKNDFLGMVEFSPKTLQQ-KPPKGWFRLLPFP-RAEEDSGGNLGAL 250 Query: 181 QLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQL-----IPLIEETTSTECRQDVA 235 +++VRL ++ VLPS YQPL+ LL V QGP + + L+EE T +CRQD+A Sbjct: 251 RVKVRLIEDRVLPSQCYQPLMELLMESV----QGPAEEDTASPLALLEELTLGDCRQDLA 306 Query: 236 TNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSVESFLKVAGMQYLHGV 295 T L+KLFLG+GLA FLD L + E++RT + NTLFRSNSLASKS+E F+K+ GM YLH V Sbjct: 307 TKLVKLFLGRGLAGHFLDYLTRREVARTMDPNTLFRSNSLASKSMEQFMKLVGMPYLHEV 366 Query: 296 LGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSAL 355 L P+I++VFEEKKY+ELDP K+++ +E ++ E S L +LG ++ A+ Sbjct: 367 LKPVISRVFEEKKYMELDPCKMDLGRTRRISFKGALSEEQMRETSLGLLTGYLGPIVDAI 426 Query: 356 SRSVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFHL 415 SV CP +R F+QL RRV ERFP A+H++V ++A++ FL LRFF+PAI++PKLF L Sbjct: 427 VGSVGRCPPAMRLAFKQLHRRVEERFPQAEHQDVKYLAISGFLFLRFFAPAILTPKLFDL 486 Query: 416 RERHADARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVHQGVAQLKDFITKLV 475 R++HAD +TSR+LLLLAKAVQ++GN+ + KE WM PL P + Q V++++DF+ +LV Sbjct: 487 RDQHADPQTSRSLLLLAKAVQSIGNLGQQLGQGKELWMAPLHPFLLQCVSRVRDFLDRLV 546 Query: 476 DIEEKDELDLQRTLSLQAPPVKEGPLFIHRTKGKGPLMSSSFKKLYFSLTTEALSFAKTP 535 D++ + R L + V+EG L + + G +FKK Y L+ E LSF+K+P Sbjct: 547 DVDGDEAGVPARALFPPSAIVREGYLLKRKEEPAGLATRFAFKKRYVWLSGETLSFSKSP 606 Query: 536 SSKKSALIKLANIRAAEKVEEKSFGGSHVMQVIYTDDAGRPQTAYLQCKCVNELNQWLSA 595 + I +++IRA E+V+E +F HVMQV+ D G T YLQCK VNELNQWLSA Sbjct: 607 EWQMCHSIPVSHIRAVERVDEGAFQLPHVMQVVTQDGTGALHTTYLQCKNVNELNQWLSA 666 Query: 596 LRKVSINNTGLLGSYHPGVFRGDKWSCCHQKEKTGQGCDKTRSRVTLQEWNDPLDHDLEA 655 LRK S N L + HPG FR +W+CC Q E++ GC +T S VTL +W+DPLD D EA Sbjct: 667 LRKASAPNPNKLAACHPGAFRSARWTCCLQAERSAAGCSRTHSAVTLGDWSDPLDPDAEA 726 Query: 656 QLIYRHLLGVEAMLWERHRELSGGAEAGTVPTSPGKVPE------DSLARLLRVLQDLRE 709 Q +YR LL L R + L T+ G PE + ARLL VL DL Sbjct: 727 QTVYRQLLLGRDQL--RLKLLEDSNMDTTLEADTGACPEVLARQRAATARLLEVLADLDR 784 Query: 710 AH 711 AH Sbjct: 785 AH 786 Score = 40.4 bits (93), Expect = 0.006 Identities = 27/87 (31%), Positives = 40/87 (45%), Gaps = 2/87 (2%) Query: 58 ARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGR-TRETSIVKKSCYPRWNETFEFEL 116 A++ L V+E R L KD +G+SDP+ V+ T+ V +S P W E + L Sbjct: 2 AKSSSLNVRVVEGRALPAKDVSGSSDPYCLVKVDDEVVARTATVWRSLGPFWGEEYTVHL 61 Query: 117 QEGAMEALCVEAWDWDLVSRNDFLGKV 143 L D D V +D +GK+ Sbjct: 62 PLD-FHQLAFYVLDEDTVGHDDIIGKI 87 >gi|12545408 RAS p21 protein activator 2 [Homo sapiens] Length = 849 Score = 293 bits (751), Expect = 3e-79 Identities = 211/723 (29%), Positives = 349/723 (48%), Gaps = 65/723 (8%) Query: 2 DEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEIHLRLE----VWPG 57 D++ L RD IGKV + ++ + +H G W L VD + EVQG++HL L+ + Sbjct: 108 DKNVLQRDLRIGKVAIKKEDLCNH-SGKETWFSLQPVDSNSEVQGKVHLELKLNELITEN 166 Query: 58 ARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTR----ETSIVKKSCYPRWNETF- 112 C+ ++A P + DP+ V G +R +T + KK+ P++NE F Sbjct: 167 GTVCQQLVVHIKACHGLPLINGQSCDPYATVSLVGPSRNDQKKTKVKKKTSNPQFNEIFY 226 Query: 113 -------------EFELQEGAMEAL--CVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEE 157 +F+++E +E L ++ W+ + ++ FLG++ + V LR + Sbjct: 227 FEVTRSSSYTRKSQFQVEEEDIEKLEIRIDLWNNGNLVQDVFLGEIKVPVNVLRTDSSHQ 286 Query: 158 GWFRLQPDQSKSRRHDEGNLGSLQLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQ 217 W+ LQP + ++ +LGSL+L + ++ VLPS YY PL LL + Sbjct: 287 AWYLLQPRDNGNKSSKTDDLGSLRLNICYTEDYVLPSEYYGPLKTLLLKSPDVQPISASA 346 Query: 218 LIPLIEETTSTECRQDVATNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLAS 277 L E + D L++L L F + +L+L T + NT+FR NSLA+ Sbjct: 347 AYILSEICRD---KNDAVLPLVRLLLHHDKLVPFATAVAELDLKDTQDANTIFRGNSLAT 403 Query: 278 KSVESFLKVAGMQYLHGVLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVL 337 + ++ +K+ G YL L PI++++ + K E+DP K++ E + + Sbjct: 404 RCLDEMMKIVGGHYLKVTLKPILDEICDSSKSCEIDPIKLK--------------EGDNV 449 Query: 338 EQSAQTLRAHLGALLSALSRSVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSF 397 E + + LR ++ L + + +S +CP V+ F L + +RFP H V + AV+SF Sbjct: 450 ENNKENLRYYVDKLFNTIVKSSMSCPTVMCDIFYSLRQMATQRFPNDPH--VQYSAVSSF 507 Query: 398 LCLRFFSPAIMSPKLFHLRERHADARTSRTLLLLAKAVQNV---GNMDTPASRAKEAWM- 453 + LRFF+ A++SP FHLR H DA+T RTL L++K +Q + G++ S KE +M Sbjct: 508 VFLRFFAVAVVSPHTFHLRPHHPDAQTIRTLTLISKTIQTLGSWGSLSKSKSSFKETFMC 567 Query: 454 EPLQPTVHQG-VAQLKDFITKLVDIEEKDELDLQRTLSLQAPPVKEGPLFIHRTKGKGPL 512 E + +G + +K F+ ++ E K+ + L KEG ++ R +G+ + Sbjct: 568 EFFKMFQEEGYIIAVKKFLDEISSTETKESSGTSEPVHL-----KEGEMY-KRAQGRTRI 621 Query: 513 MSSSFKKLYFSLTTEALSFAKTPSSKKSALIKLANIRAAEKVEEKSFGGSHVMQVIYTDD 572 +FKK +F LT+ L++ K P I + NI A EK+EE SF ++ QVI+T+ Sbjct: 622 GKKNFKKRWFCLTSRELTYHKQPGKDAIYTIPVKNILAVEKLEESSFNKKNMFQVIHTE- 680 Query: 573 AGRPQTAYLQCKCVNELNQWLSALRKVSINNTGLLGSYHPGVFRGDKWSCCHQKEKTGQG 632 + Y+Q E N+W+ L +VS N L YHP V+ W CC + + G Sbjct: 681 ----KPLYVQANNCVEANEWIDVLCRVSRCNQNRLSFYHPSVYLNGNWLCCQETGENTLG 736 Query: 633 CDKTRSRVTLQEWNDPLDHDLEAQLIYRHLLGVEAMLWERHRELSGGAEAGTVPTSPGKV 692 C + V D +D D E + IY L + + ++ E G V P K Sbjct: 737 CKPCTAGVPADIQID-IDEDRETERIY-SLFTLSLLKLQKMEEACGTI---AVYQGPQKE 791 Query: 693 PED 695 P+D Sbjct: 792 PDD 794 Score = 45.8 bits (107), Expect = 1e-04 Identities = 44/152 (28%), Positives = 71/152 (46%), Gaps = 10/152 (6%) Query: 63 LRCSVLEARDLAPK-DRNGTSDPFVRVRY-KGRTRETSIVKKSCYPRWNETFEFELQEGA 120 LR + EA++L P + D F + + T +V+KS P ++E F FE+ Sbjct: 40 LRGKICEAKNLLPYLGPHKMRDCFCTINLDQEEVYRTQVVEKSLSPFFSEEFYFEIPR-T 98 Query: 121 MEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGNLGSL 180 + L +D +++ R+ +GKV I + L +E WF LQP S S G + Sbjct: 99 FQYLSFYVYDKNVLQRDLRIGKVAIKKEDLCNHSGKETWFSLQPVDSNSEVQ-----GKV 153 Query: 181 QLEVRLRDETVLPSSYYQPL-VHL-LCHEVKL 210 LE++L + + Q L VH+ CH + L Sbjct: 154 HLELKLNELITENGTVCQQLVVHIKACHGLPL 185 >gi|38201692 RAS p21 protein activator 3 [Homo sapiens] Length = 834 Score = 283 bits (725), Expect = 3e-76 Identities = 206/687 (29%), Positives = 328/687 (47%), Gaps = 63/687 (9%) Query: 2 DEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEIHLRLEVWP----- 56 D D RD +IGKV + ++ + + + W L VD D EVQG++HL L + Sbjct: 82 DRDVFRRDSIIGKVAIQKEDLQKYHNRDT-WFQLQHVDADSEVQGKVHLELRLSEVITDT 140 Query: 57 GARACRLRCSVLEARDLAPKDRNGTSDPFVRVR----YKGRTRETSIVKKSCYPRWNETF 112 G +L ++E + L NG DP+ V ++ ++T + +K+ P+++E F Sbjct: 141 GVVCHKLATRIVECQGLPIV--NGQCDPYATVTLAGPFRSEAKKTKVKRKTNNPQFDEVF 198 Query: 113 EFEL--------------QEGAMEALCVEAWDWD---LVSRNDFLGKVVIDVQRLRVVQQ 155 FE+ +E ++ L + W+ L ++FLG++ I ++ LR Sbjct: 199 YFEVTRPCSYSKKSHFDFEEEDVDKLEIRVDLWNASNLKFGDEFLGELRIPLKVLRQSSS 258 Query: 156 EEGWFRLQPDQSKSRRHDEGNLGSLQLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGP 215 E W+ LQP + S+ +LGSL+L V ++ V S YY PL LL + Sbjct: 259 YEAWYFLQPRDNGSKSLKPDDLGSLRLNVVYTEDHVFSSDYYSPLRDLLLKSADVEPVSA 318 Query: 216 GQLIPLIEETTSTECRQDVATNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSL 275 L E +Q+ A L++LFL G F+ + E+ RT + NT+FR NSL Sbjct: 319 SAAHILGEVCRE---KQEAAVPLVRLFLHYGRVVPFISAIASAEVKRTQDPNTIFRGNSL 375 Query: 276 ASKSVESFLKVAGMQYLHGVLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAE 335 ASK ++ +K+AGM YLH L P I ++ + K E+DP K++ + E Sbjct: 376 ASKCIDETMKLAGMHYLHVTLKPAIEEICQSHKPCEIDPVKLK--------------DGE 421 Query: 336 VLEQSAQTLRAHLGALLSALSRSVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVT 395 LE + + LR ++ + A++ S +CP V+ F L +RF +V + AV+ Sbjct: 422 NLENNMENLRQYVDRVFHAITESGVSCPTVMCDIFFSLREAAAKRF--QDDPDVRYTAVS 479 Query: 396 SFLCLRFFSPAIMSPKLFHLRERHADARTSRTLLLLAKAVQNVGNMDTPASRA-KEAWME 454 SF+ LRFF+PAI+SP LF L H D +TSRTL L++K VQ +G++ S + KE++M Sbjct: 480 SFIFLRFFAPAILSPNLFQLTPHHTDPQTSRTLTLISKTVQTLGSLSKSKSASFKESYMA 539 Query: 455 PLQPTVHQG--VAQLKDFITKLVDIEEKDELDLQRTLSLQAPPVKEGPLFIHRTKGKGPL 512 ++ +K+F+ + +D +++ + L KEG I R +G+ Sbjct: 540 TFYEFFNEQKYADAVKNFLDLISSSGRRDPKSVEQPIVL-----KEG-FMIKRAQGRKRF 593 Query: 513 MSSSFKKLYFSLTTEALSFAKTPSSKKSALIKLANIRAAEKVEEKSFGGSHVMQVIYTDD 572 +FKK +F LT ++ K+ + I + NI A EK+EE+SF ++ QVI + Sbjct: 594 GMKNFKKRWFRLTNHEFTYHKSKGDQPLYSIPIENILAVEKLEEESFKMKNMFQVIQPER 653 Query: 573 AGRPQTAYLQCKCVNELNQWLSALRKVSINNTGLLGSYHPGVFRGDKWSCCHQKEKTGQG 632 A Y+Q E W+ L KVS N L YHP + W CC + G Sbjct: 654 A-----LYIQANNCVEAKDWIDILTKVSQCNQKRLTVYHPSAYLSGHWLCCRAPSDSAPG 708 Query: 633 CDKTRSRVTLQEWNDPLDHDLEAQLIY 659 C + D +D D E + IY Sbjct: 709 CSPCTGGLPANIQLD-IDGDRETERIY 734 Score = 40.8 bits (94), Expect = 0.005 Identities = 28/92 (30%), Positives = 44/92 (47%), Gaps = 6/92 (6%) Query: 97 TSIVKKSCYPRWNETFEFELQEGAMEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQE 156 T IV+KS P + E F E+ + L +D D+ R+ +GKV I + L+ Sbjct: 50 TKIVEKSLCPFYGEDFYCEIPR-SFRHLSFYIFDRDVFRRDSIIGKVAIQKEDLQKYHNR 108 Query: 157 EGWFRLQPDQSKSRRHDEGNLGSLQLEVRLRD 188 + WF+LQ + S G + LE+RL + Sbjct: 109 DTWFQLQHVDADSEVQ-----GKVHLELRLSE 135 >gi|226958575 RAS protein activator like 2 isoform 2 [Homo sapiens] Length = 1280 Score = 132 bits (333), Expect = 9e-31 Identities = 117/407 (28%), Positives = 189/407 (46%), Gaps = 54/407 (13%) Query: 49 HLRLEVWPGARACR-----LRCSVLEARDLAPKDRNGTS---DPFVRVRYKGRTRETSIV 100 +LR V P CR LR ++EA+DLAPK + D + R +T+ +I Sbjct: 300 NLRRTVQPNKDNCRRAENVLRLWIIEAKDLAPKKKYFCELCLDDTLFARTTSKTKADNIF 359 Query: 101 KKSCYPRWNETFEFELQEGAMEALCVEAWDWDLVSR-----NDFLGKVVIDVQRLRVVQQ 155 W E FEF + ++ V + D+ + N+++G V I + Q Sbjct: 360 -------WGEHFEF-FSLPPLHSITVHIYK-DVEKKKKKDKNNYVGLVNIPTASVTGRQF 410 Query: 156 EEGWFRLQ-PDQSKSRRHDEGNLGSLQLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQG 214 E W+ + P +K + S++++ R + T+LP Y+ + + Sbjct: 411 VEKWYPVSTPTPNKGKTGGP----SIRIKSRFQTITILPMEQYKEFAEFVTSNYTM---- 462 Query: 215 PGQLIPLIEETTSTECRQDVATNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTL-FRSN 273 L ++E S ++++A L+ + G AKDFL L E+ R E + L FR N Sbjct: 463 ---LCSVLEPVISVRNKEELACALVHILQSTGRAKDFLTDLVMSEVDRCGEHDVLIFREN 519 Query: 274 SLASKSVESFLKVAGMQYLHGVLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTE 333 ++A+KS+E +LK+ G QYLH LG I ++E + E+DPSK CS Sbjct: 520 TIATKSIEEYLKLVGQQYLHDALGEFIKALYESDENCEVDPSK-------CSS------- 565 Query: 334 AEVLEQSAQTLRAHLGALLSALSRSVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIA 393 +E+++ + L+ + S P ++ F ++ R G Q + I+ Sbjct: 566 SELIDHQSN-LKMCCELAFCKIINSYCVFPRELKEVFASWKQQCLNR--GKQDISERLIS 622 Query: 394 VTSFLCLRFFSPAIMSPKLFHLRERHADARTSRTLLLLAKAVQNVGN 440 + FL RF PAIMSP LF+L + + D RTSRTL L+AK +QN+ N Sbjct: 623 ASLFL--RFLCPAIMSPSLFNLMQEYPDDRTSRTLTLIAKVIQNLAN 667 >gi|4758808 RAS protein activator like 2 isoform 1 [Homo sapiens] Length = 1139 Score = 132 bits (333), Expect = 9e-31 Identities = 117/407 (28%), Positives = 189/407 (46%), Gaps = 54/407 (13%) Query: 49 HLRLEVWPGARACR-----LRCSVLEARDLAPKDRNGTS---DPFVRVRYKGRTRETSIV 100 +LR V P CR LR ++EA+DLAPK + D + R +T+ +I Sbjct: 152 NLRRTVQPNKDNCRRAENVLRLWIIEAKDLAPKKKYFCELCLDDTLFARTTSKTKADNIF 211 Query: 101 KKSCYPRWNETFEFELQEGAMEALCVEAWDWDLVSR-----NDFLGKVVIDVQRLRVVQQ 155 W E FEF + ++ V + D+ + N+++G V I + Q Sbjct: 212 -------WGEHFEF-FSLPPLHSITVHIYK-DVEKKKKKDKNNYVGLVNIPTASVTGRQF 262 Query: 156 EEGWFRLQ-PDQSKSRRHDEGNLGSLQLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQG 214 E W+ + P +K + S++++ R + T+LP Y+ + + Sbjct: 263 VEKWYPVSTPTPNKGKTGGP----SIRIKSRFQTITILPMEQYKEFAEFVTSNYTM---- 314 Query: 215 PGQLIPLIEETTSTECRQDVATNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTL-FRSN 273 L ++E S ++++A L+ + G AKDFL L E+ R E + L FR N Sbjct: 315 ---LCSVLEPVISVRNKEELACALVHILQSTGRAKDFLTDLVMSEVDRCGEHDVLIFREN 371 Query: 274 SLASKSVESFLKVAGMQYLHGVLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTE 333 ++A+KS+E +LK+ G QYLH LG I ++E + E+DPSK CS Sbjct: 372 TIATKSIEEYLKLVGQQYLHDALGEFIKALYESDENCEVDPSK-------CSS------- 417 Query: 334 AEVLEQSAQTLRAHLGALLSALSRSVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIA 393 +E+++ + L+ + S P ++ F ++ R G Q + I+ Sbjct: 418 SELIDHQSN-LKMCCELAFCKIINSYCVFPRELKEVFASWKQQCLNR--GKQDISERLIS 474 Query: 394 VTSFLCLRFFSPAIMSPKLFHLRERHADARTSRTLLLLAKAVQNVGN 440 + FL RF PAIMSP LF+L + + D RTSRTL L+AK +QN+ N Sbjct: 475 ASLFL--RFLCPAIMSPSLFNLMQEYPDDRTSRTLTLIAKVIQNLAN 519 >gi|41281683 disabled homolog 2 interacting protein isoform 2 [Homo sapiens] Length = 1065 Score = 118 bits (295), Expect = 2e-26 Identities = 113/443 (25%), Positives = 192/443 (43%), Gaps = 54/443 (12%) Query: 63 LRCSVLEARDLAPKDRNGTS---DPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEG 119 L+ V+EA+DL K + D + R G+ + ++ W E FEF Sbjct: 91 LKLWVIEAKDLPAKKKYLCELCLDDVLYARTTGKLKTDNVF-------WGEHFEFHNLPP 143 Query: 120 AMEA---LCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGN 176 L E RN +LG V + + Q E W+ P + + + +G Sbjct: 144 LRTVTVHLYRETDKKKKKERNSYLGLVSLPAASVAGRQFVEKWY---PVVTPNPKGGKGP 200 Query: 177 LGSLQLEVRLRDETVLPSSYYQPLV-HLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVA 235 ++++ R + T+LP Y+ H+ H + L +E S + ++++A Sbjct: 201 GPMIRIKARYQTITILPMEMYKEFAEHITNHYLGL--------CAALEPILSAKTKEEMA 252 Query: 236 TNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTL-FRSNSLASKSVESFLKVAGMQYLHG 294 + L+ + G KDFL L E+ R + L FR N+LA+K++E +LK+ G +YL Sbjct: 253 SALVHILQSTGKVKDFLTDLMMSEVDRCGDNEHLIFRENTLATKAIEEYLKLVGQKYLQD 312 Query: 295 VLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSA 354 LG I ++E + E+DPSK CS P+ + L+ Sbjct: 313 ALGEFIKALYESDENCEVDPSK-------CSAADLPEHQGN--------LKMCCELAFCK 357 Query: 355 LSRSVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFH 414 + S P ++ ++F R+ ++ +++ L LRF PAIMSP LF+ Sbjct: 358 IINSYCVFPRELK----EVFASWRQECSSRGRPDISERLISASLFLRFLCPAIMSPSLFN 413 Query: 415 LRERHADARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVHQGVAQLKDFITKL 474 L + + D RT+RTL L+AK QN+ N S KE +M + + ++ F+ ++ Sbjct: 414 LLQEYPDDRTARTLTLIAKVTQNLANFAKFGS--KEEYMSFMNQFLEHEWTNMQRFLLEI 471 Query: 475 VDIEE-------KDELDLQRTLS 490 + E + +DL R LS Sbjct: 472 SNPETLSNTAGFEGYIDLGRELS 494 >gi|94967023 disabled homolog 2 interacting protein isoform 1 [Homo sapiens] Length = 1132 Score = 118 bits (295), Expect = 2e-26 Identities = 113/443 (25%), Positives = 192/443 (43%), Gaps = 54/443 (12%) Query: 63 LRCSVLEARDLAPKDRNGTS---DPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEG 119 L+ V+EA+DL K + D + R G+ + ++ W E FEF Sbjct: 187 LKLWVIEAKDLPAKKKYLCELCLDDVLYARTTGKLKTDNVF-------WGEHFEFHNLPP 239 Query: 120 AMEA---LCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGN 176 L E RN +LG V + + Q E W+ P + + + +G Sbjct: 240 LRTVTVHLYRETDKKKKKERNSYLGLVSLPAASVAGRQFVEKWY---PVVTPNPKGGKGP 296 Query: 177 LGSLQLEVRLRDETVLPSSYYQPLV-HLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVA 235 ++++ R + T+LP Y+ H+ H + L +E S + ++++A Sbjct: 297 GPMIRIKARYQTITILPMEMYKEFAEHITNHYLGL--------CAALEPILSAKTKEEMA 348 Query: 236 TNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTL-FRSNSLASKSVESFLKVAGMQYLHG 294 + L+ + G KDFL L E+ R + L FR N+LA+K++E +LK+ G +YL Sbjct: 349 SALVHILQSTGKVKDFLTDLMMSEVDRCGDNEHLIFRENTLATKAIEEYLKLVGQKYLQD 408 Query: 295 VLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSA 354 LG I ++E + E+DPSK CS P+ + L+ Sbjct: 409 ALGEFIKALYESDENCEVDPSK-------CSAADLPEHQGN--------LKMCCELAFCK 453 Query: 355 LSRSVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFH 414 + S P ++ ++F R+ ++ +++ L LRF PAIMSP LF+ Sbjct: 454 IINSYCVFPRELK----EVFASWRQECSSRGRPDISERLISASLFLRFLCPAIMSPSLFN 509 Query: 415 LRERHADARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVHQGVAQLKDFITKL 474 L + + D RT+RTL L+AK QN+ N S KE +M + + ++ F+ ++ Sbjct: 510 LLQEYPDDRTARTLTLIAKVTQNLANFAKFGS--KEEYMSFMNQFLEHEWTNMQRFLLEI 567 Query: 475 VDIEE-------KDELDLQRTLS 490 + E + +DL R LS Sbjct: 568 SNPETLSNTAGFEGYIDLGRELS 590 >gi|194248068 synaptic Ras GTPase activating protein 1 [Homo sapiens] Length = 1343 Score = 115 bits (289), Expect = 1e-25 Identities = 107/410 (26%), Positives = 179/410 (43%), Gaps = 56/410 (13%) Query: 63 LRCSVLEARDLAPKDRNGTS---DPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEG 119 L+ ++EAR+L PK R D + R + R S W E FEF Sbjct: 264 LKLWIIEARELPPKKRYYCELCLDDMLYARTTSKPRSAS----GDTVFWGEHFEFN-NLP 318 Query: 120 AMEALCVEAW-DWDLVSRND---FLGKVVIDVQRLRVVQQEEGWFRLQPDQSK------- 168 A+ AL + + D D + D ++G V + V L E W+ + Sbjct: 319 AVRALRLHLYRDSDKKRKKDKAGYVGLVTVPVATLAGRHFTEQWYPVTLPTGSGGSGGMG 378 Query: 169 ----------SRRHDEGNLGSLQLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQL 218 S +G +++L+ R + ++LP Y+ + + ++ L Sbjct: 379 SGGGGGSGGGSGGKGKGGCPAVRLKARYQTMSILPMELYKEFAEYVTNHYRM-------L 431 Query: 219 IPLIEETTSTECRQDVATNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTL-FRSNSLAS 277 ++E + + +++VA+ L+ + G AKDFL + E+ R E L FR N+LA+ Sbjct: 432 CAVLEPALNVKGKEEVASALVHILQSTGKAKDFLSDMAMSEVDRFMEREHLIFRENTLAT 491 Query: 278 KSVESFLKVAGMQYLHGVLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVL 337 K++E ++++ G +YL +G I ++E ++ E+DP K C+ A L Sbjct: 492 KAIEEYMRLIGQKYLKDAIGEFIRALYESEENCEVDPIK-------CT--------ASSL 536 Query: 338 EQSAQTLRAHLGALLSALSRSVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSF 397 + LR L + S P ++ F R ER E++ +++ Sbjct: 537 AEHQANLRMCCELALCKVVNSHCVFPRELKEVFASWRLRCAER----GREDIADRLISAS 592 Query: 398 LCLRFFSPAIMSPKLFHLRERHADARTSRTLLLLAKAVQNVGNMDTPASR 447 L LRF PAIMSP LF L + + D +TSRTL L+AK +QN+ N S+ Sbjct: 593 LFLRFLCPAIMSPSLFGLMQEYPDEQTSRTLTLIAKVIQNLANFSKFTSK 642 >gi|4506431 RAS p21 protein activator 1 isoform 1 [Homo sapiens] Length = 1047 Score = 105 bits (263), Expect = 1e-22 Identities = 89/326 (27%), Positives = 148/326 (45%), Gaps = 46/326 (14%) Query: 178 GSLQLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQD---V 234 GSL++ R E ++P Y L+ + + S C QD + Sbjct: 704 GSLRVRARYSMEKIMPEEEYSEFKELILQKELH-----------VVYALSHVCGQDRTLL 752 Query: 235 ATNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSVESFLKVAGMQYLHG 294 A+ LL++FL + L L L E+S E TLFR+ +LAS +E ++K Q++H Sbjct: 753 ASILLRIFLHEKLESLLLCTLNDREISMEDEATTLFRATTLASTLMEQYMKATATQFVHH 812 Query: 295 VLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSA 354 L I K+ E K+ EL PSK+E + T HL +LS Sbjct: 813 ALKDSILKIMESKQSCELSPSKLE------------------KNEDVNTNLTHLLNILSE 854 Query: 355 LSRSVRACPAVVRATFRQLF----RRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSP 410 L + ++ T R ++ + V+ ++P + + V+ F+ LR PAI++P Sbjct: 855 LVEKIFMASEILPPTLRYIYGCLQKSVQHKWP--TNTTMRTRVVSGFVFLRLICPAILNP 912 Query: 411 KLFHLRERHADARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTV----HQGVAQ 466 ++F++ +RTL+L+AK+VQN+ N+ AKE +ME + P + H+ + Sbjct: 913 RMFNIISDSPSPIAARTLILVAKSVQNLANL--VEFGAKEPYMEGVNPFIKSNKHRMIMF 970 Query: 467 LKDF--ITKLVDIEEKDELDLQRTLS 490 L + + +L D E DL R L+ Sbjct: 971 LDELGNVPELPDTTEHSRTDLSRDLA 996 >gi|12545406 RAS p21 protein activator 1 isoform 2 [Homo sapiens] Length = 870 Score = 105 bits (263), Expect = 1e-22 Identities = 89/326 (27%), Positives = 148/326 (45%), Gaps = 46/326 (14%) Query: 178 GSLQLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQD---V 234 GSL++ R E ++P Y L+ + + S C QD + Sbjct: 527 GSLRVRARYSMEKIMPEEEYSEFKELILQKELH-----------VVYALSHVCGQDRTLL 575 Query: 235 ATNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSVESFLKVAGMQYLHG 294 A+ LL++FL + L L L E+S E TLFR+ +LAS +E ++K Q++H Sbjct: 576 ASILLRIFLHEKLESLLLCTLNDREISMEDEATTLFRATTLASTLMEQYMKATATQFVHH 635 Query: 295 VLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSA 354 L I K+ E K+ EL PSK+E + T HL +LS Sbjct: 636 ALKDSILKIMESKQSCELSPSKLE------------------KNEDVNTNLTHLLNILSE 677 Query: 355 LSRSVRACPAVVRATFRQLF----RRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSP 410 L + ++ T R ++ + V+ ++P + + V+ F+ LR PAI++P Sbjct: 678 LVEKIFMASEILPPTLRYIYGCLQKSVQHKWP--TNTTMRTRVVSGFVFLRLICPAILNP 735 Query: 411 KLFHLRERHADARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTV----HQGVAQ 466 ++F++ +RTL+L+AK+VQN+ N+ AKE +ME + P + H+ + Sbjct: 736 RMFNIISDSPSPIAARTLILVAKSVQNLANL--VEFGAKEPYMEGVNPFIKSNKHRMIMF 793 Query: 467 LKDF--ITKLVDIEEKDELDLQRTLS 490 L + + +L D E DL R L+ Sbjct: 794 LDELGNVPELPDTTEHSRTDLSRDLA 819 >gi|130502162 RAS protein activator like 3 [Homo sapiens] Length = 1011 Score = 87.0 bits (214), Expect = 5e-17 Identities = 76/303 (25%), Positives = 135/303 (44%), Gaps = 31/303 (10%) Query: 179 SLQLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVATNL 238 +L+ +R R VLPS Y+ L L +L +E + ++++A + Sbjct: 414 ALRARIRARRLRVLPSERYKELAEFLTFHY-------ARLCGALEPALPAQAKEELAAAM 466 Query: 239 LKLFLGQGLAKDFLDLLFQLELSRTSETNTL-FRSNSLASKSVESFLKVAGMQYLHGVLG 297 +++ G A+ + L EL+R L FR N+LA+K+++ ++K+ YL LG Sbjct: 467 VRVLRATGRAQALVTDLGTAELARCGGREALLFRENTLATKAIDEYMKLVAQDYLQETLG 526 Query: 298 PIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSALSR 357 ++ ++ + E+DPSK C P+ +A LR + + Sbjct: 527 QVVRRLCASTEDCEVDPSK-------CPASELPEHQAR--------LRNSCEEVFETIIH 571 Query: 358 SVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFHLRE 417 S PA + F +ER G++ + + F LR PAI++P LF L Sbjct: 572 SYDWFPAELGIVFSSWREACKER--GSEVLGPRLVCASLF--LRLLCPAILAPSLFGLAP 627 Query: 418 RHADARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVHQGVAQLKDFITK--LV 475 H +RTL L+AK +QN+ N P KEA+M + + + ++ F+ + +V Sbjct: 628 DHPAPGPARTLTLIAKVIQNLANR-APFGE-KEAYMGFMNSFLEEHGPAMQCFLDQVAMV 685 Query: 476 DIE 478 D++ Sbjct: 686 DVD 688 >gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens] Length = 671 Score = 84.0 bits (206), Expect = 5e-16 Identities = 43/102 (42%), Positives = 63/102 (61%), Gaps = 7/102 (6%) Query: 67 VLEARDLAPKDRNGTSDPFVRVRY----KGRTRE-TSIVKKSCYPRWNETFEFELQEGAM 121 V +A++L P D NG SDP+V+++ K +++ T +K S P WNETF F+L+E Sbjct: 177 VRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQLKESDK 236 Query: 122 EA-LCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRL 162 + L VE WDWDL SRNDF+G + + L+ +GWF+L Sbjct: 237 DRRLSVEIWDWDLTSRNDFMGSLSFGISELQKA-SVDGWFKL 277 >gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens] Length = 673 Score = 84.0 bits (206), Expect = 5e-16 Identities = 43/102 (42%), Positives = 63/102 (61%), Gaps = 7/102 (6%) Query: 67 VLEARDLAPKDRNGTSDPFVRVRY----KGRTRE-TSIVKKSCYPRWNETFEFELQEGAM 121 V +A++L P D NG SDP+V+++ K +++ T +K S P WNETF F+L+E Sbjct: 177 VRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQLKESDK 236 Query: 122 EA-LCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRL 162 + L VE WDWDL SRNDF+G + + L+ +GWF+L Sbjct: 237 DRRLSVEIWDWDLTSRNDFMGSLSFGISELQKA-SVDGWFKL 277 >gi|13384594 protein kinase C, gamma [Homo sapiens] Length = 697 Score = 81.3 bits (199), Expect = 3e-15 Identities = 49/119 (41%), Positives = 68/119 (57%), Gaps = 8/119 (6%) Query: 50 LRLEVWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTR-----ETSIVKKSC 104 L+LE+ A + +V EAR+L P D NG SDP+V+++ R +T VK + Sbjct: 161 LQLEI-RAPTADEIHVTVGEARNLIPMDPNGLSDPYVKLKLIPDPRNLTKQKTRTVKATL 219 Query: 105 YPRWNETFEFELQEGAMEA-LCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRL 162 P WNETF F L+ G +E L VE WDWD SRNDF+G + V L + +GW++L Sbjct: 220 NPVWNETFVFNLKPGDVERRLSVEVWDWDRTSRNDFMGAMSFGVSEL-LKAPVDGWYKL 277 >gi|4506067 protein kinase C, alpha [Homo sapiens] Length = 672 Score = 79.0 bits (193), Expect = 1e-14 Identities = 44/126 (34%), Positives = 73/126 (57%), Gaps = 11/126 (8%) Query: 43 EVQGEIHLRLEVWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRY----KGRTRE-T 97 E +G I+L+ EV +L +V +A++L P D NG SDP+V+++ K +++ T Sbjct: 157 EKRGRIYLKAEVADE----KLHVTVRDAKNLIPMDPNGLSDPYVKLKLIPDPKNESKQKT 212 Query: 98 SIVKKSCYPRWNETFEFELQEGAMEA-LCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQE 156 ++ + P+WNE+F F+L+ + L VE WDWD +RNDF+G + V L + Sbjct: 213 KTIRSTLNPQWNESFTFKLKPSDKDRRLSVEIWDWDRTTRNDFMGSLSFGVSEL-MKMPA 271 Query: 157 EGWFRL 162 GW++L Sbjct: 272 SGWYKL 277 >gi|4557793 neurofibromin isoform 2 [Homo sapiens] Length = 2818 Score = 77.0 bits (188), Expect = 6e-14 Identities = 71/256 (27%), Positives = 114/256 (44%), Gaps = 27/256 (10%) Query: 189 ETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVATNLLKLFLGQGLA 248 ETVL + ++ LV L+ +G QG + + ++A L+ LF + L Sbjct: 1198 ETVL-ADRFERLVELV---TMMGDQGELPIAMALANVVPCSQWDELARVLVTLFDSRHLL 1253 Query: 249 KDFLDLLFQLELSRTSETNTLFRSNSLASKSVESFLKVAGMQYLHGVLGPIINKVFEEKK 308 L +F E+ TLFR NSLASK + KV G YL +L P++ V Sbjct: 1254 YQLLWNMFSKEVELADSMQTLFRGNSLASKIMTFCFKVYGATYLQKLLDPLLRIVITSSD 1313 Query: 309 Y----VELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSALSRSVRACPA 364 + E+DP+++E +E LE++ + L A+ S P Sbjct: 1314 WQHVSFEVDPTRLE--------------PSESLEENQRNLLQMTEKFFHAIISSSSEFPP 1359 Query: 365 VVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFHLRERHADART 424 +R+ L++ V +RFP AV S + LRF +PAI+SP + ++ R Sbjct: 1360 QLRSVCHCLYQVVSQRFP-----QNSIGAVGSAMFLRFINPAIVSPYEAGILDKKPPPRI 1414 Query: 425 SRTLLLLAKAVQNVGN 440 R L L++K +Q++ N Sbjct: 1415 ERGLKLMSKILQSIAN 1430 >gi|150170670 piccolo isoform 2 [Homo sapiens] Length = 4935 Score = 74.7 bits (182), Expect = 3e-13 Identities = 50/153 (32%), Positives = 79/153 (51%), Gaps = 28/153 (18%) Query: 44 VQGEIHLRLEVWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRV--------------- 88 + GEI L++ G L +L+AR+L P+D NG SDPFV+V Sbjct: 4694 ITGEIQLQINYDLG----NLIIHILQARNLVPRDNNGYSDPFVKVYLLPGRGQVMVVQNA 4749 Query: 89 --RYKGRTRETSIVKKSCYPRWNETFEFE---LQEGAMEALCVEAWDWDLVSRNDFLGKV 143 YK RT+ V+KS P WN+T ++ +++ + L V WD+D S NDFLG+V Sbjct: 4750 SAEYKRRTKH---VQKSLNPEWNQTVIYKSISMEQLKKKTLEVTVWDYDRFSSNDFLGEV 4806 Query: 144 VIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGN 176 +ID+ + W+ L+ +Q++S H + + Sbjct: 4807 LIDLSSTSHLDNTPRWYPLK-EQTESIDHGKSH 4838 >gi|150378539 piccolo isoform 1 [Homo sapiens] Length = 5142 Score = 74.7 bits (182), Expect = 3e-13 Identities = 50/153 (32%), Positives = 79/153 (51%), Gaps = 28/153 (18%) Query: 44 VQGEIHLRLEVWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRV--------------- 88 + GEI L++ G L +L+AR+L P+D NG SDPFV+V Sbjct: 4694 ITGEIQLQINYDLG----NLIIHILQARNLVPRDNNGYSDPFVKVYLLPGRGQVMVVQNA 4749 Query: 89 --RYKGRTRETSIVKKSCYPRWNETFEFE---LQEGAMEALCVEAWDWDLVSRNDFLGKV 143 YK RT+ V+KS P WN+T ++ +++ + L V WD+D S NDFLG+V Sbjct: 4750 SAEYKRRTKH---VQKSLNPEWNQTVIYKSISMEQLKKKTLEVTVWDYDRFSSNDFLGEV 4806 Query: 144 VIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGN 176 +ID+ + W+ L+ +Q++S H + + Sbjct: 4807 LIDLSSTSHLDNTPRWYPLK-EQTESIDHGKSH 4838 >gi|50582996 multiple C2 domains, transmembrane 1 isoform S [Homo sapiens] Length = 778 Score = 71.6 bits (174), Expect = 2e-12 Identities = 34/104 (32%), Positives = 58/104 (55%), Gaps = 4/104 (3%) Query: 47 EIHLRLEVWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYP 106 ++H + +W G + +++E RDL D NG SDP+V+ R + ++ I+ K+ P Sbjct: 239 DLHRKSHLWRGI----VSITLIEGRDLKAMDSNGLSDPYVKFRLGHQKYKSKIMPKTLNP 294 Query: 107 RWNETFEFELQEGAMEALCVEAWDWDLVSRNDFLGKVVIDVQRL 150 +W E F+F L E + + AWD D R+DF+G+ +D+ L Sbjct: 295 QWREQFDFHLYEERGGVIDITAWDKDAGKRDDFIGRCQVDLSAL 338 Score = 50.8 bits (120), Expect = 4e-06 Identities = 38/139 (27%), Positives = 69/139 (49%), Gaps = 14/139 (10%) Query: 62 RLRCSVLEARDLAPKDRNGTSDPFVRVRYKGR-TRETSIVKKSCYPRWNETFEFELQEGA 120 +L ++ + LA +DR GTSDP+V+ + G+ + I+ K+ P W E L + Sbjct: 41 QLDITLRRGQSLAARDRGGTSDPYVKFKIGGKEVFRSKIIHKNLNPVWEEK-ACILVDHL 99 Query: 121 MEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGNLGSL 180 E L ++ +D+D ++DF+G +D+ +L + + + L K + + +LG + Sbjct: 100 REPLYIKVFDYDFGLQDDFMGSAFLDLTQLELNRPTDVTLTL-----KDPHYPDHDLGII 154 Query: 181 QLEVRL-------RDETVL 192 L V L RD T+L Sbjct: 155 LLSVILTPKEGESRDVTML 173 Score = 47.8 bits (112), Expect = 4e-05 Identities = 31/94 (32%), Positives = 44/94 (46%), Gaps = 1/94 (1%) Query: 63 LRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEGAME 122 L+ V+ A L D G SDPF V T V K+ P WN+ F F +++ Sbjct: 407 LQVKVIRAEGLMAADVTGKSDPFCVVELNNDRLLTHTVYKNLNPEWNKVFTFNIKD-IHS 465 Query: 123 ALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQE 156 L V +D D DFLGKV I + ++ +Q+ Sbjct: 466 VLEVTVYDEDRDRSADFLGKVAIPLLSIQNGEQK 499 >gi|205361109 multiple C2 domains, transmembrane 1 isoform L [Homo sapiens] Length = 999 Score = 71.6 bits (174), Expect = 2e-12 Identities = 34/104 (32%), Positives = 58/104 (55%), Gaps = 4/104 (3%) Query: 47 EIHLRLEVWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYP 106 ++H + +W G + +++E RDL D NG SDP+V+ R + ++ I+ K+ P Sbjct: 460 DLHRKSHLWRGI----VSITLIEGRDLKAMDSNGLSDPYVKFRLGHQKYKSKIMPKTLNP 515 Query: 107 RWNETFEFELQEGAMEALCVEAWDWDLVSRNDFLGKVVIDVQRL 150 +W E F+F L E + + AWD D R+DF+G+ +D+ L Sbjct: 516 QWREQFDFHLYEERGGVIDITAWDKDAGKRDDFIGRCQVDLSAL 559 Score = 50.8 bits (120), Expect = 4e-06 Identities = 38/139 (27%), Positives = 69/139 (49%), Gaps = 14/139 (10%) Query: 62 RLRCSVLEARDLAPKDRNGTSDPFVRVRYKGR-TRETSIVKKSCYPRWNETFEFELQEGA 120 +L ++ + LA +DR GTSDP+V+ + G+ + I+ K+ P W E L + Sbjct: 262 QLDITLRRGQSLAARDRGGTSDPYVKFKIGGKEVFRSKIIHKNLNPVWEEK-ACILVDHL 320 Query: 121 MEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGNLGSL 180 E L ++ +D+D ++DF+G +D+ +L + + + L K + + +LG + Sbjct: 321 REPLYIKVFDYDFGLQDDFMGSAFLDLTQLELNRPTDVTLTL-----KDPHYPDHDLGII 375 Query: 181 QLEVRL-------RDETVL 192 L V L RD T+L Sbjct: 376 LLSVILTPKEGESRDVTML 394 Score = 47.8 bits (112), Expect = 4e-05 Identities = 31/94 (32%), Positives = 44/94 (46%), Gaps = 1/94 (1%) Query: 63 LRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEGAME 122 L+ V+ A L D G SDPF V T V K+ P WN+ F F +++ Sbjct: 628 LQVKVIRAEGLMAADVTGKSDPFCVVELNNDRLLTHTVYKNLNPEWNKVFTFNIKD-IHS 686 Query: 123 ALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQE 156 L V +D D DFLGKV I + ++ +Q+ Sbjct: 687 VLEVTVYDEDRDRSADFLGKVAIPLLSIQNGEQK 720 >gi|38570146 synaptotagmin VII [Homo sapiens] Length = 403 Score = 70.5 bits (171), Expect = 5e-12 Identities = 42/116 (36%), Positives = 66/116 (56%), Gaps = 8/116 (6%) Query: 63 LRCSVLEARDLAPKDRNGTSDPFVRVRY---KGRTRETSIVKKSCYPRWNETFEFE---L 116 L +++A++L KD +GTSDPFV++ K ET + +K+ P WNETF FE Sbjct: 152 LTVKIMKAQELPAKDFSGTSDPFVKIYLLPDKKHKLETKVKRKNLNPHWNETFLFEGFPY 211 Query: 117 QEGAMEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQP--DQSKSR 170 ++ L ++ D+D SRND +G+V I + ++ + Q + W L+P D S SR Sbjct: 212 EKVVQRILYLQVLDYDRFSRNDPIGEVSIPLNKVDLTQMQTFWKDLKPCSDGSGSR 267 Score = 62.0 bits (149), Expect = 2e-09 Identities = 45/153 (29%), Positives = 81/153 (52%), Gaps = 12/153 (7%) Query: 1 MDEDALSRDDVIGKVCLTRDTI-ASHPKGFSGWAHLTEVDPDEEVQGEIHLRLEVWPGAR 59 +D D SR+D IG+V + + + + + F W L +GE+ L L P A Sbjct: 224 LDYDRFSRNDPIGEVSIPLNKVDLTQMQTF--WKDLKPCSDGSGSRGELLLSLCYNPSAN 281 Query: 60 ACRLRCSVLEARDLAPKDRNGTSDPFVRV--RYKGR---TRETSIVKKSCYPRWNETFEF 114 + + ++++AR+L D GTSDP+V+V YK + ++T +K++ P +NE+F F Sbjct: 282 S--IIVNIIKARNLKAMDIGGTSDPYVKVWLMYKDKRVEKKKTVTMKRNLNPIFNESFAF 339 Query: 115 ELQEGAME--ALCVEAWDWDLVSRNDFLGKVVI 145 ++ + + + D D +SRND +GK+ + Sbjct: 340 DIPTEKLRETTIIITVMDKDKLSRNDVIGKIYL 372 >gi|109826564 neurofibromin isoform 1 [Homo sapiens] Length = 2839 Score = 68.6 bits (166), Expect = 2e-11 Identities = 68/269 (25%), Positives = 115/269 (42%), Gaps = 32/269 (11%) Query: 189 ETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVATNLLKLFLGQGLA 248 ETVL + ++ LV L+ +G QG + + ++A L+ LF + L Sbjct: 1198 ETVL-ADRFERLVELV---TMMGDQGELPIAMALANVVPCSQWDELARVLVTLFDSRHLL 1253 Query: 249 KDFLDLLFQLELSRTSETNTLFRSNSLASKSVESFLKVAGMQYLHGVLGPIINKVFEEKK 308 L +F E+ TLFR NSLASK + KV G YL +L P++ V Sbjct: 1254 YQLLWNMFSKEVELADSMQTLFRGNSLASKIMTFCFKVYGATYLQKLLDPLLRIVITSSD 1313 Query: 309 Y----VELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSALSRSVRACPA 364 + E+DP+++E + + + +L+ + + A + + + C Sbjct: 1314 WQHVSFEVDPTRLEPSE------SLEENQRNLLQMTEKFFHAIISSSSEFPPQLRSVCHC 1367 Query: 365 VVRATFRQLFRR-------------VRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPK 411 + +AT L + V +RFP AV S + LRF +PAI+SP Sbjct: 1368 LYQATCHSLLNKATVKEKKENKKSVVSQRFP-----QNSIGAVGSAMFLRFINPAIVSPY 1422 Query: 412 LFHLRERHADARTSRTLLLLAKAVQNVGN 440 + ++ R R L L++K +Q++ N Sbjct: 1423 EAGILDKKPPPRIERGLKLMSKILQSIAN 1451 >gi|47078261 double C2-like domains, alpha [Homo sapiens] Length = 400 Score = 64.3 bits (155), Expect = 4e-10 Identities = 58/204 (28%), Positives = 85/204 (41%), Gaps = 33/204 (16%) Query: 2 DEDALSRDDVIGKV-----------------CLTRDTIASHPKGFSGW-----AHLTEVD 39 DED LS ++ IG++ CL R + P S +L E++ Sbjct: 181 DEDKLSHNEFIGEIRVPLRRLKPSQKKHFNICLERQVPLASPSSMSAALRGISCYLKELE 240 Query: 40 PDEEVQGEIHLR----LEVWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRY----- 90 E+ QG + R L + +R L +L LA D NG SDP+V+ Sbjct: 241 QAEQGQGLLEERGRILLSLSYSSRRRGLLVGILRCAHLAAMDVNGYSDPYVKTYLRPDVD 300 Query: 91 KGRTRETSIVKKSCYPRWNETF--EFELQEGAMEALCVEAWDWDLVSRNDFLGKVVIDVQ 148 K +T + KK+ P +NE F E EL A + L V WD+D+ NDF+G V + Sbjct: 301 KKSKHKTCVKKKTLNPEFNEEFFYEIELSTLATKTLEVTVWDYDIGKSNDFIGGVSLGPG 360 Query: 149 RLRVVQQEEGWFRLQPDQSKSRRH 172 ++ QPD + R H Sbjct: 361 ARGEARKHWSDCLQQPDAALERWH 384 Score = 55.8 bits (133), Expect = 1e-07 Identities = 30/105 (28%), Positives = 55/105 (52%), Gaps = 8/105 (7%) Query: 60 ACRLRCSVLEARDLAPKDRNGTSDPFVRVRY-----KGRTRETSIVKKSCYPRWNETFEF 114 +C L CS+L A+ L P D NG +DP+V++ K +T + + P WNE + Sbjct: 103 SCTLHCSILRAKGLKPMDFNGLADPYVKLHLLPGACKANKLKTKTQRNTLNPVWNEDLTY 162 Query: 115 E---LQEGAMEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQE 156 + + L + D D +S N+F+G++ + ++RL+ Q++ Sbjct: 163 SGITDDDITHKVLRIAVCDEDKLSHNEFIGEIRVPLRRLKPSQKK 207 >gi|40068038 B/K protein [Homo sapiens] Length = 474 Score = 64.3 bits (155), Expect = 4e-10 Identities = 48/152 (31%), Positives = 78/152 (51%), Gaps = 10/152 (6%) Query: 1 MDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEIHLRLEVWPGARA 60 +D D SR VIGKV + + KG W L +E GE+ L L P A Sbjct: 279 VDFDKFSRHCVIGKVSVPLCEV-DLVKGGHWWKALIPSSQNEVELGELLLSLNYLPSAG- 336 Query: 61 CRLRCSVLEARDLAPKDRNGTSDPFVRVRYKG-----RTRETSIVKKSCYPRWNETFEFE 115 RL V+ A+ L D + SDPFV+++ +T++TS ++ + P +NE+F F+ Sbjct: 337 -RLNVDVIRAKQLLQTDVSQGSDPFVKIQLVHGLKLVKTKKTSFLRGTIDPFYNESFSFK 395 Query: 116 LQEGAME--ALCVEAWDWDLVSRNDFLGKVVI 145 + + +E +L + ++ S NDF+G++VI Sbjct: 396 VPQEELENASLVFTVFGHNMKSSNDFIGRIVI 427 Score = 41.6 bits (96), Expect = 0.003 Identities = 36/134 (26%), Positives = 64/134 (47%), Gaps = 17/134 (12%) Query: 63 LRCSVLEARDLAPK-DRNGT------SDPFVRVRY---KGRTRETSIVKKSCYPRWNETF 112 L V+EARDL P +G+ S+P+V++ + +++T + +K+ P + E + Sbjct: 201 LTVRVIEARDLPPPISHDGSRQDMAHSNPYVKICLLPDQKNSKQTGVKRKTQKPVFEERY 260 Query: 113 EFELQ--EGAMEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSR 170 FE+ E L + D+D SR+ +GKV + + + +V+ W L P Sbjct: 261 TFEIPFLEAQRRTLLLTVVDFDKFSRHCVIGKVSVPLCEVDLVKGGHWWKALIPSS---- 316 Query: 171 RHDEGNLGSLQLEV 184 +E LG L L + Sbjct: 317 -QNEVELGELLLSL 329 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.318 0.134 0.399 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 28,385,294 Number of Sequences: 37866 Number of extensions: 1284213 Number of successful extensions: 3901 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 90 Number of HSP's successfully gapped in prelim test: 84 Number of HSP's that attempted gapping in prelim test: 3396 Number of HSP's gapped (non-prelim): 375 length of query: 731 length of database: 18,247,518 effective HSP length: 110 effective length of query: 621 effective length of database: 14,082,258 effective search space: 8745082218 effective search space used: 8745082218 T: 11 A: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits) S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.