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Search of human proteins with 23943850
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|23943850 calcium/calmodulin-dependent protein kinase ID
isoform 2 [Homo sapiens]
(385 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|23943850 calcium/calmodulin-dependent protein kinase ID isofo... 769 0.0
gi|9966875 calcium/calmodulin-dependent protein kinase ID isofor... 696 0.0
gi|4502553 calcium/calmodulin-dependent protein kinase I [Homo s... 547 e-156
gi|14196445 calcium/calmodulin-dependent protein kinase IG [Homo... 483 e-136
gi|209364621 pregnancy upregulated non-ubiquitously expressed Ca... 457 e-129
gi|209364619 pregnancy upregulated non-ubiquitously expressed Ca... 457 e-129
gi|83776596 CaM kinase-like vesicle-associated [Homo sapiens] 296 3e-80
gi|27901803 protein serine kinase H1 [Homo sapiens] 285 6e-77
gi|4502557 calcium/calmodulin-dependent protein kinase IV [Homo ... 274 1e-73
gi|14916455 protein serine kinase H2 [Homo sapiens] 254 7e-68
gi|4758128 doublecortin-like kinase 1 [Homo sapiens] 252 3e-67
gi|156713430 doublecortin-like kinase 2 isoform b [Homo sapiens] 247 1e-65
gi|156713428 doublecortin-like kinase 2 isoform a [Homo sapiens] 247 1e-65
gi|25952118 calcium/calmodulin-dependent protein kinase II alpha... 243 2e-64
gi|25952114 calcium/calmodulin-dependent protein kinase II alpha... 243 2e-64
gi|26051212 calcium/calmodulin-dependent protein kinase II beta ... 243 2e-64
gi|26667196 calcium/calmodulin-dependent protein kinase II gamma... 240 2e-63
gi|26051208 calcium/calmodulin-dependent protein kinase II beta ... 240 2e-63
gi|26051210 calcium/calmodulin-dependent protein kinase II beta ... 239 2e-63
gi|26051214 calcium/calmodulin-dependent protein kinase II beta ... 239 3e-63
gi|26051216 calcium/calmodulin-dependent protein kinase II beta ... 238 5e-63
gi|26051204 calcium/calmodulin-dependent protein kinase II beta ... 237 1e-62
gi|26051206 calcium/calmodulin-dependent protein kinase II beta ... 237 1e-62
gi|26051218 calcium/calmodulin-dependent protein kinase II beta ... 237 2e-62
gi|149589021 doublecortin-like kinase 3 [Homo sapiens] 236 2e-62
gi|26667183 calcium/calmodulin-dependent protein kinase II delta... 236 3e-62
gi|26667186 calcium/calmodulin-dependent protein kinase II delta... 236 3e-62
gi|26667189 calcium/calmodulin-dependent protein kinase II delta... 236 3e-62
gi|26667180 calcium/calmodulin-dependent protein kinase II delta... 236 3e-62
gi|26667199 calcium/calmodulin-dependent protein kinase II gamma... 236 3e-62
>gi|23943850 calcium/calmodulin-dependent protein kinase ID isoform
2 [Homo sapiens]
Length = 385
Score = 769 bits (1985), Expect = 0.0
Identities = 385/385 (100%), Positives = 385/385 (100%)
Query: 1 MARENGESSSSWKKQAEDIKKIFEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALK 60
MARENGESSSSWKKQAEDIKKIFEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALK
Sbjct: 1 MARENGESSSSWKKQAEDIKKIFEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALK 60
Query: 61 GKESSIENEIAVLRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKD 120
GKESSIENEIAVLRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKD
Sbjct: 61 GKESSIENEIAVLRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKD 120
Query: 121 ASTLIRQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMST 180
ASTLIRQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMST
Sbjct: 121 ASTLIRQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMST 180
Query: 181 ACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEF 240
ACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEF
Sbjct: 181 ACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEF 240
Query: 241 DSPYWDDISDSAKDFIRNLMEKDPNKRYTCEQAARHPWIAGDTALNKNIHESVSAQIRKN 300
DSPYWDDISDSAKDFIRNLMEKDPNKRYTCEQAARHPWIAGDTALNKNIHESVSAQIRKN
Sbjct: 241 DSPYWDDISDSAKDFIRNLMEKDPNKRYTCEQAARHPWIAGDTALNKNIHESVSAQIRKN 300
Query: 301 FAKSKWRQAFNATAVVRHMRKLHLGSSLDSSNASVSSSLSLASQKDCLAPSTLCSFISSS 360
FAKSKWRQAFNATAVVRHMRKLHLGSSLDSSNASVSSSLSLASQKDCLAPSTLCSFISSS
Sbjct: 301 FAKSKWRQAFNATAVVRHMRKLHLGSSLDSSNASVSSSLSLASQKDCLAPSTLCSFISSS 360
Query: 361 SGVSGVGAERRPRPTTVTAVHSGSK 385
SGVSGVGAERRPRPTTVTAVHSGSK
Sbjct: 361 SGVSGVGAERRPRPTTVTAVHSGSK 385
>gi|9966875 calcium/calmodulin-dependent protein kinase ID isoform 1
[Homo sapiens]
Length = 357
Score = 696 bits (1796), Expect = 0.0
Identities = 347/347 (100%), Positives = 347/347 (100%)
Query: 1 MARENGESSSSWKKQAEDIKKIFEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALK 60
MARENGESSSSWKKQAEDIKKIFEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALK
Sbjct: 1 MARENGESSSSWKKQAEDIKKIFEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALK 60
Query: 61 GKESSIENEIAVLRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKD 120
GKESSIENEIAVLRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKD
Sbjct: 61 GKESSIENEIAVLRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKD 120
Query: 121 ASTLIRQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMST 180
ASTLIRQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMST
Sbjct: 121 ASTLIRQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMST 180
Query: 181 ACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEF 240
ACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEF
Sbjct: 181 ACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEF 240
Query: 241 DSPYWDDISDSAKDFIRNLMEKDPNKRYTCEQAARHPWIAGDTALNKNIHESVSAQIRKN 300
DSPYWDDISDSAKDFIRNLMEKDPNKRYTCEQAARHPWIAGDTALNKNIHESVSAQIRKN
Sbjct: 241 DSPYWDDISDSAKDFIRNLMEKDPNKRYTCEQAARHPWIAGDTALNKNIHESVSAQIRKN 300
Query: 301 FAKSKWRQAFNATAVVRHMRKLHLGSSLDSSNASVSSSLSLASQKDC 347
FAKSKWRQAFNATAVVRHMRKLHLGSSLDSSNASVSSSLSLASQKDC
Sbjct: 301 FAKSKWRQAFNATAVVRHMRKLHLGSSLDSSNASVSSSLSLASQKDC 347
>gi|4502553 calcium/calmodulin-dependent protein kinase I [Homo
sapiens]
Length = 370
Score = 547 bits (1410), Expect = e-156
Identities = 266/323 (82%), Positives = 294/323 (91%)
Query: 14 KQAEDIKKIFEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESSIENEIAVL 73
KQAEDI+ I++F++ LGTGAFSEV+LAE+K T KL A+KCI K+AL+GKE S+ENEIAVL
Sbjct: 11 KQAEDIRDIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEGSMENEIAVL 70
Query: 74 RKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVY 133
KIKH NIVAL+DIYES HLYL+MQLVSGGELFDRIVEKGFYTE+DAS LI QVLDAV
Sbjct: 71 HKIKHPNIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQVLDAVK 130
Query: 134 YLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTPGYVAPEVL 193
YLH +GIVHRDLKPENLLYYS DE+SKIMISDFGLSKME G V+STACGTPGYVAPEVL
Sbjct: 131 YLHDLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLSTACGTPGYVAPEVL 190
Query: 194 AQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDDISDSAK 253
AQKPYSKAVDCWSIGVIAYILLCGYPPFYDEND+KLFEQILKAEYEFDSPYWDDISDSAK
Sbjct: 191 AQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSPYWDDISDSAK 250
Query: 254 DFIRNLMEKDPNKRYTCEQAARHPWIAGDTALNKNIHESVSAQIRKNFAKSKWRQAFNAT 313
DFIR+LMEKDP KR+TCEQA +HPWIAGDTAL+KNIH+SVS QI+KNFAKSKW+QAFNAT
Sbjct: 251 DFIRHLMEKDPEKRFTCEQALQHPWIAGDTALDKNIHQSVSEQIKKNFAKSKWKQAFNAT 310
Query: 314 AVVRHMRKLHLGSSLDSSNASVS 336
AVVRHMRKL LG+S + + S
Sbjct: 311 AVVRHMRKLQLGTSQEGQGQTAS 333
>gi|14196445 calcium/calmodulin-dependent protein kinase IG [Homo
sapiens]
Length = 476
Score = 483 bits (1243), Expect = e-136
Identities = 237/324 (73%), Positives = 277/324 (85%), Gaps = 2/324 (0%)
Query: 1 MARENGESSSSWKKQAEDIKKIFEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALK 60
M R+ + SSWKKQ +I+K F F E LG+GAFSEV L +++ TGKLFA+KCI KK+
Sbjct: 1 MGRKEEDDCSSWKKQTTNIRKTFIFMEVLGSGAFSEVFLVKQRLTGKLFALKCI-KKSPA 59
Query: 61 GKESSIENEIAVLRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKD 120
++SS+ENEIAVL+KIKHENIV LEDIYES H YLVMQLVSGGELFDRI+E+G YTEKD
Sbjct: 60 FRDSSLENEIAVLKKIKHENIVTLEDIYESTTHYYLVMQLVSGGELFDRILERGVYTEKD 119
Query: 121 ASTLIRQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMST 180
AS +I+QVL AV YLH GIVHRDLKPENLLY + +E SKIMI+DFGLSKME G +MST
Sbjct: 120 ASLVIQQVLSAVKYLHENGIVHRDLKPENLLYLTPEENSKIMITDFGLSKMEQNG-IMST 178
Query: 181 ACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEF 240
ACGTPGYVAPEVLAQKPYSKAVDCWSIGVI YILLCGYPPFY+E +SKLFE+I + YEF
Sbjct: 179 ACGTPGYVAPEVLAQKPYSKAVDCWSIGVITYILLCGYPPFYEETESKLFEKIKEGYYEF 238
Query: 241 DSPYWDDISDSAKDFIRNLMEKDPNKRYTCEQAARHPWIAGDTALNKNIHESVSAQIRKN 300
+SP+WDDIS+SAKDFI +L+EKDPN+RYTCE+A HPWI G+TAL+++I+ SVS QI+KN
Sbjct: 239 ESPFWDDISESAKDFICHLLEKDPNERYTCEKALSHPWIDGNTALHRDIYPSVSLQIQKN 298
Query: 301 FAKSKWRQAFNATAVVRHMRKLHL 324
FAKSKWRQAFNA AVV HMRKLH+
Sbjct: 299 FAKSKWRQAFNAAAVVHHMRKLHM 322
>gi|209364621 pregnancy upregulated non-ubiquitously expressed CaM
kinase isoform b [Homo sapiens]
Length = 360
Score = 457 bits (1177), Expect = e-129
Identities = 215/310 (69%), Positives = 269/310 (86%), Gaps = 1/310 (0%)
Query: 13 KKQAEDIKKIFEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESSIENEIAV 72
KK EDI ++E +E LG+GAFSEVVLA+E+ + L A+KCIPKKAL+GKE+ +ENEIAV
Sbjct: 22 KKHTEDISSVYEIRERLGSGAFSEVVLAQERGSAHLVALKCIPKKALRGKEALVENEIAV 81
Query: 73 LRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAV 132
LR+I H NIVALED++ESP+HLYL M+LV+GGELFDRI+E+G YTEKDAS L+ QVL AV
Sbjct: 82 LRRISHPNIVALEDVHESPSHLYLAMELVTGGELFDRIMERGSYTEKDASHLVGQVLGAV 141
Query: 133 YYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTPGYVAPEV 192
YLH +GIVHRDLKPENLLY + E+SKIM+SDFGLSK++ G+++ TACGTPGYVAPE+
Sbjct: 142 SYLHSLGIVHRDLKPENLLYATPFEDSKIMVSDFGLSKIQA-GNMLGTACGTPGYVAPEL 200
Query: 193 LAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDDISDSA 252
L QKPY KAVD W++GVI+YILLCGYPPFYDE+D +LF QIL+A YEFDSP+WDDIS+SA
Sbjct: 201 LEQKPYGKAVDVWALGVISYILLCGYPPFYDESDPELFSQILRASYEFDSPFWDDISESA 260
Query: 253 KDFIRNLMEKDPNKRYTCEQAARHPWIAGDTALNKNIHESVSAQIRKNFAKSKWRQAFNA 312
KDFIR+L+E+DP KR+TC+QA RH WI+GDTA +++I SVS QIRKNFA++ W++AFNA
Sbjct: 261 KDFIRHLLERDPQKRFTCQQALRHLWISGDTAFDRDILGSVSEQIRKNFARTHWKRAFNA 320
Query: 313 TAVVRHMRKL 322
T+ +RH+RKL
Sbjct: 321 TSFLRHIRKL 330
>gi|209364619 pregnancy upregulated non-ubiquitously expressed CaM
kinase isoform a [Homo sapiens]
Length = 426
Score = 457 bits (1177), Expect = e-129
Identities = 215/310 (69%), Positives = 269/310 (86%), Gaps = 1/310 (0%)
Query: 13 KKQAEDIKKIFEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESSIENEIAV 72
KK EDI ++E +E LG+GAFSEVVLA+E+ + L A+KCIPKKAL+GKE+ +ENEIAV
Sbjct: 88 KKHTEDISSVYEIRERLGSGAFSEVVLAQERGSAHLVALKCIPKKALRGKEALVENEIAV 147
Query: 73 LRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAV 132
LR+I H NIVALED++ESP+HLYL M+LV+GGELFDRI+E+G YTEKDAS L+ QVL AV
Sbjct: 148 LRRISHPNIVALEDVHESPSHLYLAMELVTGGELFDRIMERGSYTEKDASHLVGQVLGAV 207
Query: 133 YYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTPGYVAPEV 192
YLH +GIVHRDLKPENLLY + E+SKIM+SDFGLSK++ G+++ TACGTPGYVAPE+
Sbjct: 208 SYLHSLGIVHRDLKPENLLYATPFEDSKIMVSDFGLSKIQA-GNMLGTACGTPGYVAPEL 266
Query: 193 LAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDDISDSA 252
L QKPY KAVD W++GVI+YILLCGYPPFYDE+D +LF QIL+A YEFDSP+WDDIS+SA
Sbjct: 267 LEQKPYGKAVDVWALGVISYILLCGYPPFYDESDPELFSQILRASYEFDSPFWDDISESA 326
Query: 253 KDFIRNLMEKDPNKRYTCEQAARHPWIAGDTALNKNIHESVSAQIRKNFAKSKWRQAFNA 312
KDFIR+L+E+DP KR+TC+QA RH WI+GDTA +++I SVS QIRKNFA++ W++AFNA
Sbjct: 327 KDFIRHLLERDPQKRFTCQQALRHLWISGDTAFDRDILGSVSEQIRKNFARTHWKRAFNA 386
Query: 313 TAVVRHMRKL 322
T+ +RH+RKL
Sbjct: 387 TSFLRHIRKL 396
>gi|83776596 CaM kinase-like vesicle-associated [Homo sapiens]
Length = 501
Score = 296 bits (757), Expect = 3e-80
Identities = 142/332 (42%), Positives = 221/332 (66%), Gaps = 10/332 (3%)
Query: 15 QAEDIKKIFEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESSIENEIAVLR 74
Q ++ ++ + + T F E+ A++K TGKL K K+ + + +NEI +L+
Sbjct: 16 QPSEVTDRYDLGQVIKTEEFCEIFRAKDKTTGKLHTCKKFQKRDGRKVRKAAKNEIGILK 75
Query: 75 KIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYY 134
+KH NI+ L D++ + ++ ++L +G E+FD I+++G+Y+E+D S ++RQVL+AV Y
Sbjct: 76 MVKHPNILQLVDVFVTRKEYFIFLELATGREVFDWILDQGYYSERDTSNVVRQVLEAVAY 135
Query: 135 LHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTPGYVAPEVLA 194
LH + IVHR+LK ENL+YY++ + SKI+ISDF L+K+E ++ CGTP Y+APEV+
Sbjct: 136 LHSLKIVHRNLKLENLVYYNRLKNSKIVISDFHLAKLE--NGLIKEPCGTPEYLAPEVVG 193
Query: 195 QKPYSKAVDCWSIGVIAYILLCGYPPFYDE--------NDSKLFEQILKAEYEFDSPYWD 246
++ Y + VDCW+IGVI YILL G PPFY+E +D LF +IL +YEFDSPYWD
Sbjct: 194 RQRYGRPVDCWAIGVIMYILLSGNPPFYEEVEEDDYENHDKNLFRKILAGDYEFDSPYWD 253
Query: 247 DISDSAKDFIRNLMEKDPNKRYTCEQAARHPWIAGDTALNKNIHESVSAQIRKNFAKSKW 306
DIS +AKD + LME + ++R T E+A H WI+G+ A +KNI + V AQI KNFA++KW
Sbjct: 254 DISQAAKDLVTRLMEVEQDQRITAEEAISHEWISGNAASDKNIKDGVCAQIEKNFARAKW 313
Query: 307 RQAFNATAVVRHMRKLHLGSSLDSSNASVSSS 338
++A T +++ +R S+ + +AS + +
Sbjct: 314 KKAVRVTTLMKRLRAPEQSSTAAAQSASATDT 345
>gi|27901803 protein serine kinase H1 [Homo sapiens]
Length = 424
Score = 285 bits (728), Expect = 6e-77
Identities = 137/281 (48%), Positives = 195/281 (69%), Gaps = 5/281 (1%)
Query: 23 FEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESSIENEIAVLRKIKHENIV 82
++ K +G G+FS VV E +AT + +A+K I K +G+E E+E+ VLR+++H NI+
Sbjct: 98 YDIKALIGRGSFSRVVRVEHRATRQPYAIKMIETKYREGREVC-ESELRVLRRVRHANII 156
Query: 83 ALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHRMGIVH 142
L +++E+ +Y+VM+L +GGELFDRI+ KG +TE+DA+ +++ VLD V YLH +GI H
Sbjct: 157 QLVEVFETQERVYMVMELATGGELFDRIIAKGSFTERDATRVLQMVLDGVRYLHALGITH 216
Query: 143 RDLKPENLLYYSQDEESKIMISDFGLSKMEGKGD--VMSTACGTPGYVAPEVLAQKPYSK 200
RDLKPENLLYY +SKI+I+DFGL+ KGD +M T CGTP Y+APEVL +KPY+
Sbjct: 217 RDLKPENLLYYHPGTDSKIIITDFGLASARKKGDDCLMKTTCGTPEYIAPEVLVRKPYTN 276
Query: 201 AVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDDISDSAKDFIRNLM 260
+VD W++GVIAYILL G PF D+N ++L+ QIL+ +Y + W +S+ AKDFI L+
Sbjct: 277 SVDMWALGVIAYILLSGTMPFEDDNRTRLYRQILRGKYSYSGEPWPSVSNLAKDFIDRLL 336
Query: 261 EKDPNKRYTCEQAARHPWIAGDTALN--KNIHESVSAQIRK 299
DP R T QA RHPW+ A + KN+H S+S + K
Sbjct: 337 TVDPGARMTALQALRHPWVVSMAASSSMKNLHRSISQNLLK 377
>gi|4502557 calcium/calmodulin-dependent protein kinase IV [Homo
sapiens]
Length = 473
Score = 274 bits (700), Expect = 1e-73
Identities = 148/321 (46%), Positives = 207/321 (64%), Gaps = 11/321 (3%)
Query: 19 IKKIFEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESSIENEIAVLRKIKH 78
+ FE + LG GA S V ++K T K +A+K + K K + EI VL ++ H
Sbjct: 42 LSDFFEVESELGRGATSIVYRCKQKGTQKPYALKVLKKTVDK---KIVRTEIGVLLRLSH 98
Query: 79 ENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHRM 138
NI+ L++I+E+P + LV++LV+GGELFDRIVEKG+Y+E+DA+ ++Q+L+AV YLH
Sbjct: 99 PNIIKLKEIFETPTEISLVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHEN 158
Query: 139 GIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTPGYVAPEVLAQKPY 198
GIVHRDLKPENLLY + ++ + I+DFGLSK+ +M T CGTPGY APE+L Y
Sbjct: 159 GIVHRDLKPENLLYATPAPDAPLKIADFGLSKIVEHQVLMKTVCGTPGYCAPEILRGCAY 218
Query: 199 SKAVDCWSIGVIAYILLCGYPPFYDE-NDSKLFEQILKAEYEFDSPYWDDISDSAKDFIR 257
VD WS+G+I YILLCG+ PFYDE D +F +IL EY F SP+WD++S +AKD +R
Sbjct: 219 GPEVDMWSVGIITYILLCGFEPFYDERGDQFMFRRILNCEYYFISPWWDEVSLNAKDLVR 278
Query: 258 NLMEKDPNKRYTCEQAARHPWIAGDTALNKNIHESVSAQIRKNFAKSKWRQAFNATAVVR 317
L+ DP KR T QA +HPW+ G A N ++ ++++ A+ K + A AVV
Sbjct: 279 KLIVLDPKKRLTTFQALQHPWVTGKAA-NFVHMDTAQKKLQEFNARRKLKAA--VKAVVA 335
Query: 318 HMRKLHLGSSLDSSNASVSSS 338
R LGS+ SS+ S+ S
Sbjct: 336 SSR---LGSA-SSSHGSIQES 352
>gi|14916455 protein serine kinase H2 [Homo sapiens]
Length = 385
Score = 254 bits (650), Expect = 7e-68
Identities = 128/281 (45%), Positives = 189/281 (67%), Gaps = 9/281 (3%)
Query: 23 FEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESSIENEIAVLRKIKHENIV 82
++ K +GTG+FS VV E+K T K FA+K + + +G+E+ + +E++VLR++ H IV
Sbjct: 63 YDIKALIGTGSFSRVVRVEQKTTKKPFAIKVMETREREGREACV-SELSVLRRVSHRYIV 121
Query: 83 ALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHRMGIVH 142
L +I+E+ + +Y+VM+L +GGELFDR++ +G +TE+DA +++ V D + YLH + I H
Sbjct: 122 QLMEIFETEDQVYMVMELATGGELFDRLIAQGSFTERDAVRILQMVADGIRYLHALQITH 181
Query: 143 RDLKPENLLYYSQDEESKIMISDFGLSKMEGK-GD-VMSTACGTPGYVAPEVLAQKPYSK 200
R+LKPENLLYY EESKI+I+DFGL+ K GD M T CGTP Y+APEVL +KPY+
Sbjct: 182 RNLKPENLLYYHPGEESKILITDFGLAYSGKKSGDWTMKTLCGTPEYIAPEVLLRKPYTS 241
Query: 201 AVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDDISDSAKDFIRNLM 260
AVD W++GVI Y LL G+ PF DE+ ++L+ +ILK +Y + W IS AKDFI L+
Sbjct: 242 AVDMWALGVITYALLSGFLPFDDESQTRLYRKILKGKYNYTGEPWPSISHLAKDFIDKLL 301
Query: 261 EKDPNKRYTCEQAARHPWI----AGDTALNKNIHESVSAQI 297
+ R + QA HPW+ AG + KN+ ++S +
Sbjct: 302 ILEAGHRMSAGQALDHPWVITMAAGSSM--KNLQRAISRNL 340
>gi|4758128 doublecortin-like kinase 1 [Homo sapiens]
Length = 729
Score = 252 bits (644), Expect = 3e-67
Identities = 128/287 (44%), Positives = 186/287 (64%), Gaps = 7/287 (2%)
Query: 19 IKKIFEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESSIENEIAVLRKIKH 78
I + ++ T+G G F+ V E++T + +A+K I K +GKE I+NE+++LR++KH
Sbjct: 386 ITERYKVGRTIGDGNFAVVKECVERSTAREYALKIIKKSKCRGKEHMIQNEVSILRRVKH 445
Query: 79 ENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHRM 138
NIV L + + P LYLVM+LV GG+LFD I YTE+DAS ++ + A+ YLH +
Sbjct: 446 PNIVLLIEEMDVPTELYLVMELVKGGDLFDAITSTNKYTERDASGMLYNLASAIKYLHSL 505
Query: 139 GIVHRDLKPENLLYYS-QDEESKIMISDFGLSKMEGKGDVMSTACGTPGYVAPEVLAQKP 197
IVHRD+KPENLL Y QD + + DFGL+ + + T CGTP YVAPE++A+
Sbjct: 506 NIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATI--VDGPLYTVCGTPTYVAPEIIAETG 563
Query: 198 YSKAVDCWSIGVIAYILLCGYPPFYDENDSK--LFEQILKAEYEFDSPYWDDISDSAKDF 255
Y VD W+ GVI YILLCG+PPF D + LF+QIL + +F SPYWD++SDSAK+
Sbjct: 564 YGLKVDIWAAGVITYILLCGFPPFRGSGDDQEVLFDQILMGQVDFPSPYWDNVSDSAKEL 623
Query: 256 IRNLMEKDPNKRYTCEQAARHPWIAGDTALNKNIHE-SVSAQIRKNF 301
I ++ D ++R++ Q HPW+ D L +N H+ SV+ +I+K+F
Sbjct: 624 ITMMLLVDVDQRFSAVQVLEHPWV-NDDGLPENEHQLSVAGKIKKHF 669
>gi|156713430 doublecortin-like kinase 2 isoform b [Homo sapiens]
Length = 765
Score = 247 bits (630), Expect = 1e-65
Identities = 125/297 (42%), Positives = 188/297 (63%), Gaps = 7/297 (2%)
Query: 23 FEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESSIENEIAVLRKIKHENIV 82
++ + +G G F+ V +++TGK FA+K I K GKE IENE+++LR++KH NI+
Sbjct: 393 YKIGKVIGDGNFAVVKECIDRSTGKEFALKIIDKAKCCGKEHLIENEVSILRRVKHPNII 452
Query: 83 ALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHRMGIVH 142
L + E+ L+LVM+LV GG+LFD I YTE+D S ++ + +A+ YLH + IVH
Sbjct: 453 MLVEEMETATELFLVMELVKGGDLFDAITSSTKYTERDGSAMVYNLANALRYLHGLSIVH 512
Query: 143 RDLKPENLLYYSQDEESK-IMISDFGLSK-MEGKGDVMSTACGTPGYVAPEVLAQKPYSK 200
RD+KPENLL + +K + + DFGL+ +EG + T CGTP YVAPE++A+ Y
Sbjct: 513 RDIKPENLLVCEYPDGTKSLKLGDFGLATVVEGP---LYTVCGTPTYVAPEIIAETGYGL 569
Query: 201 AVDCWSIGVIAYILLCGYPPFYDEND--SKLFEQILKAEYEFDSPYWDDISDSAKDFIRN 258
VD W+ GVI YILLCG+PPF EN+ LF+QIL + EF +PYWD+I+DSAK+ I
Sbjct: 570 KVDIWAAGVITYILLCGFPPFRSENNLQEDLFDQILAGKLEFPAPYWDNITDSAKELISQ 629
Query: 259 LMEKDPNKRYTCEQAARHPWIAGDTALNKNIHESVSAQIRKNFAKSKWRQAFNATAV 315
+++ + R T Q HPW++ D + N+ V+ +++++F + +Q T V
Sbjct: 630 MLQVNVEARCTAGQILSHPWVSDDASQENNMQAEVTGKLKQHFNNALPKQNSTTTGV 686
>gi|156713428 doublecortin-like kinase 2 isoform a [Homo sapiens]
Length = 766
Score = 247 bits (630), Expect = 1e-65
Identities = 125/297 (42%), Positives = 188/297 (63%), Gaps = 7/297 (2%)
Query: 23 FEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESSIENEIAVLRKIKHENIV 82
++ + +G G F+ V +++TGK FA+K I K GKE IENE+++LR++KH NI+
Sbjct: 394 YKIGKVIGDGNFAVVKECIDRSTGKEFALKIIDKAKCCGKEHLIENEVSILRRVKHPNII 453
Query: 83 ALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHRMGIVH 142
L + E+ L+LVM+LV GG+LFD I YTE+D S ++ + +A+ YLH + IVH
Sbjct: 454 MLVEEMETATELFLVMELVKGGDLFDAITSSTKYTERDGSAMVYNLANALRYLHGLSIVH 513
Query: 143 RDLKPENLLYYSQDEESK-IMISDFGLSK-MEGKGDVMSTACGTPGYVAPEVLAQKPYSK 200
RD+KPENLL + +K + + DFGL+ +EG + T CGTP YVAPE++A+ Y
Sbjct: 514 RDIKPENLLVCEYPDGTKSLKLGDFGLATVVEGP---LYTVCGTPTYVAPEIIAETGYGL 570
Query: 201 AVDCWSIGVIAYILLCGYPPFYDEND--SKLFEQILKAEYEFDSPYWDDISDSAKDFIRN 258
VD W+ GVI YILLCG+PPF EN+ LF+QIL + EF +PYWD+I+DSAK+ I
Sbjct: 571 KVDIWAAGVITYILLCGFPPFRSENNLQEDLFDQILAGKLEFPAPYWDNITDSAKELISQ 630
Query: 259 LMEKDPNKRYTCEQAARHPWIAGDTALNKNIHESVSAQIRKNFAKSKWRQAFNATAV 315
+++ + R T Q HPW++ D + N+ V+ +++++F + +Q T V
Sbjct: 631 MLQVNVEARCTAGQILSHPWVSDDASQENNMQAEVTGKLKQHFNNALPKQNSTTTGV 687
>gi|25952118 calcium/calmodulin-dependent protein kinase II alpha
isoform 2 [Homo sapiens]
Length = 478
Score = 243 bits (621), Expect = 2e-64
Identities = 125/294 (42%), Positives = 182/294 (61%), Gaps = 3/294 (1%)
Query: 23 FEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKE-SSIENEIAVLRKIKHENI 81
++ E LG GAFS V + G+ +A K I K L ++ +E E + R +KH NI
Sbjct: 13 YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNI 72
Query: 82 VALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHRMGIV 141
V L D H YL+ LV+GGELF+ IV + +Y+E DAS I+Q+L+AV + H+MG+V
Sbjct: 73 VRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVV 132
Query: 142 HRDLKPENLLYYSQDEESKIMISDFGLS-KMEGKGDVMSTACGTPGYVAPEVLAQKPYSK 200
HRDLKPENLL S+ + + + ++DFGL+ ++EG+ GTPGY++PEVL + PY K
Sbjct: 133 HRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYGK 192
Query: 201 AVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDDISDSAKDFIRNLM 260
VD W+ GVI YILL GYPPF+DE+ +L++QI Y+F SP WD ++ AKD I ++
Sbjct: 193 PVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKML 252
Query: 261 EKDPNKRYTCEQAARHPWIAGDTALNKNIHESVSAQIRKNF-AKSKWRQAFNAT 313
+P+KR T +A +HPWI+ + + +H + K F A+ K + A T
Sbjct: 253 TINPSKRITAAEALKHPWISHRSTVASCMHRQETVDCLKKFNARRKLKGAILTT 306
>gi|25952114 calcium/calmodulin-dependent protein kinase II alpha
isoform 1 [Homo sapiens]
Length = 489
Score = 243 bits (621), Expect = 2e-64
Identities = 125/294 (42%), Positives = 182/294 (61%), Gaps = 3/294 (1%)
Query: 23 FEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKE-SSIENEIAVLRKIKHENI 81
++ E LG GAFS V + G+ +A K I K L ++ +E E + R +KH NI
Sbjct: 13 YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNI 72
Query: 82 VALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHRMGIV 141
V L D H YL+ LV+GGELF+ IV + +Y+E DAS I+Q+L+AV + H+MG+V
Sbjct: 73 VRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVV 132
Query: 142 HRDLKPENLLYYSQDEESKIMISDFGLS-KMEGKGDVMSTACGTPGYVAPEVLAQKPYSK 200
HRDLKPENLL S+ + + + ++DFGL+ ++EG+ GTPGY++PEVL + PY K
Sbjct: 133 HRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYGK 192
Query: 201 AVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDDISDSAKDFIRNLM 260
VD W+ GVI YILL GYPPF+DE+ +L++QI Y+F SP WD ++ AKD I ++
Sbjct: 193 PVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKML 252
Query: 261 EKDPNKRYTCEQAARHPWIAGDTALNKNIHESVSAQIRKNF-AKSKWRQAFNAT 313
+P+KR T +A +HPWI+ + + +H + K F A+ K + A T
Sbjct: 253 TINPSKRITAAEALKHPWISHRSTVASCMHRQETVDCLKKFNARRKLKGAILTT 306
>gi|26051212 calcium/calmodulin-dependent protein kinase II beta
isoform 5 [Homo sapiens]
Length = 503
Score = 243 bits (620), Expect = 2e-64
Identities = 137/360 (38%), Positives = 204/360 (56%), Gaps = 13/360 (3%)
Query: 23 FEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKE-SSIENEIAVLRKIKHENI 81
++ E +G GAFS V + TG +A K I K L ++ +E E + R +KH NI
Sbjct: 14 YQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKHSNI 73
Query: 82 VALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHRMGIV 141
V L D YLV LV+GGELF+ IV + +Y+E DAS I+Q+L+AV + H+MG+V
Sbjct: 74 VRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVV 133
Query: 142 HRDLKPENLLYYSQDEESKIMISDFGLS-KMEGKGDVMSTACGTPGYVAPEVLAQKPYSK 200
HRDLKPENLL S+ + + + ++DFGL+ +++G GTPGY++PEVL ++ Y K
Sbjct: 134 HRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKEAYGK 193
Query: 201 AVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDDISDSAKDFIRNLM 260
VD W+ GVI YILL GYPPF+DE+ KL++QI Y+F SP WD ++ AK+ I ++
Sbjct: 194 PVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQML 253
Query: 261 EKDPNKRYTCEQAARHPWIAGDTALNKNIHESVSAQIRKNF-AKSKWRQAFNATAVVRHM 319
+P KR T +A +HPW+ + + +H + + K F A+ K + A T +
Sbjct: 254 TINPAKRITAHEALKHPWVCQRSTVASMMHRQETVECLKKFNARRKLKGAILTTMLA--T 311
Query: 320 RKLHLGSSLDSSNA--------SVSSSLSLASQKDCLAPSTLCSFISSSSGVSGVGAERR 371
R SL + A S +S + S K L P+ L S S+++ + A+ R
Sbjct: 312 RNFSAAKSLLNKKADGVKPQTNSTKNSAAATSPKGTLPPAALESSDSANTTIEDEDAKAR 371
>gi|26667196 calcium/calmodulin-dependent protein kinase II gamma
isoform 2 [Homo sapiens]
Length = 527
Score = 240 bits (612), Expect = 2e-63
Identities = 130/329 (39%), Positives = 197/329 (59%), Gaps = 3/329 (0%)
Query: 23 FEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKE-SSIENEIAVLRKIKHENI 81
++ E LG GAFS V +K + + +A K I K L ++ +E E + R +KH NI
Sbjct: 14 YQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNI 73
Query: 82 VALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHRMGIV 141
V L D YLV LV+GGELF+ IV + +Y+E DAS I Q+L++V ++H+ IV
Sbjct: 74 VRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQHDIV 133
Query: 142 HRDLKPENLLYYSQDEESKIMISDFGLS-KMEGKGDVMSTACGTPGYVAPEVLAQKPYSK 200
HRDLKPENLL S+ + + + ++DFGL+ +++G+ GTPGY++PEVL + PY K
Sbjct: 134 HRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRKDPYGK 193
Query: 201 AVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDDISDSAKDFIRNLM 260
VD W+ GVI YILL GYPPF+DE+ KL++QI Y+F SP WD ++ AK+ I ++
Sbjct: 194 PVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQML 253
Query: 261 EKDPNKRYTCEQAARHPWIAGDTALNKNIHESVSAQ-IRKNFAKSKWRQAFNATAVVRHM 319
+P KR T +QA +HPW+ + + +H + + +RK A+ K + A T +V
Sbjct: 254 TINPAKRITADQALKHPWVCQRSTVASMMHRQETVECLRKFNARRKLKGAILTTMLVSRN 313
Query: 320 RKLHLGSSLDSSNASVSSSLSLASQKDCL 348
+ SS +S A+ ++ L+ + K L
Sbjct: 314 FSVGRQSSAPASPAASAAGLAGQAAKSLL 342
>gi|26051208 calcium/calmodulin-dependent protein kinase II beta
isoform 3 [Homo sapiens]
Length = 518
Score = 240 bits (612), Expect = 2e-63
Identities = 133/342 (38%), Positives = 195/342 (57%), Gaps = 13/342 (3%)
Query: 23 FEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKE-SSIENEIAVLRKIKHENI 81
++ E +G GAFS V + TG +A K I K L ++ +E E + R +KH NI
Sbjct: 14 YQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKHSNI 73
Query: 82 VALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHRMGIV 141
V L D YLV LV+GGELF+ IV + +Y+E DAS I+Q+L+AV + H+MG+V
Sbjct: 74 VRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVV 133
Query: 142 HRDLKPENLLYYSQDEESKIMISDFGLS-KMEGKGDVMSTACGTPGYVAPEVLAQKPYSK 200
HRDLKPENLL S+ + + + ++DFGL+ +++G GTPGY++PEVL ++ Y K
Sbjct: 134 HRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKEAYGK 193
Query: 201 AVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDDISDSAKDFIRNLM 260
VD W+ GVI YILL GYPPF+DE+ KL++QI Y+F SP WD ++ AK+ I ++
Sbjct: 194 PVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQML 253
Query: 261 EKDPNKRYTCEQAARHPWIAGDTALNKNIHESVSAQIRKNF-AKSKWRQAFNATAVVRHM 319
+P KR T +A +HPW+ + + +H + + K F A+ K + A T +
Sbjct: 254 TINPAKRITAHEALKHPWVCQRSTVASMMHRQETVECLKKFNARRKLKGAILTTMLA--T 311
Query: 320 RKLHLGSSLDSSNA--------SVSSSLSLASQKDCLAPSTL 353
R SL + A S +S + S K L P+ L
Sbjct: 312 RNFSAAKSLLNKKADGVKPQTNSTKNSAAATSPKGTLPPAAL 353
>gi|26051210 calcium/calmodulin-dependent protein kinase II beta
isoform 4 [Homo sapiens]
Length = 517
Score = 239 bits (611), Expect = 2e-63
Identities = 133/339 (39%), Positives = 193/339 (56%), Gaps = 8/339 (2%)
Query: 23 FEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKE-SSIENEIAVLRKIKHENI 81
++ E +G GAFS V + TG +A K I K L ++ +E E + R +KH NI
Sbjct: 14 YQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKHSNI 73
Query: 82 VALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHRMGIV 141
V L D YLV LV+GGELF+ IV + +Y+E DAS I+Q+L+AV + H+MG+V
Sbjct: 74 VRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVV 133
Query: 142 HRDLKPENLLYYSQDEESKIMISDFGLS-KMEGKGDVMSTACGTPGYVAPEVLAQKPYSK 200
HRDLKPENLL S+ + + + ++DFGL+ +++G GTPGY++PEVL ++ Y K
Sbjct: 134 HRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKEAYGK 193
Query: 201 AVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDDISDSAKDFIRNLM 260
VD W+ GVI YILL GYPPF+DE+ KL++QI Y+F SP WD ++ AK+ I ++
Sbjct: 194 PVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQML 253
Query: 261 EKDPNKRYTCEQAARHPWIAGDTALNKNIHESVSAQIRKNF-AKSKWRQAFNAT--AVVR 317
+P KR T +A +HPW+ + + +H + + K F A+ K + A T A
Sbjct: 254 TINPAKRITAHEALKHPWVCQRSTVASMMHRQETVECLKKFNARRKLKGAILTTMLATRN 313
Query: 318 HMRKLHLGSSLDS---SNASVSSSLSLASQKDCLAPSTL 353
K L D S +S + S K L P+ L
Sbjct: 314 FSAKSLLNKKADGVKPQTNSTKNSAAATSPKGTLPPAAL 352
>gi|26051214 calcium/calmodulin-dependent protein kinase II beta
isoform 6 [Homo sapiens]
Length = 492
Score = 239 bits (610), Expect = 3e-63
Identities = 133/362 (36%), Positives = 200/362 (55%), Gaps = 15/362 (4%)
Query: 23 FEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKE-SSIENEIAVLRKIKHENI 81
++ E +G GAFS V + TG +A K I K L ++ +E E + R +KH NI
Sbjct: 14 YQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKHSNI 73
Query: 82 VALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHRMGIV 141
V L D YLV LV+GGELF+ IV + +Y+E DAS I+Q+L+AV + H+MG+V
Sbjct: 74 VRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVV 133
Query: 142 HRDLKPENLLYYSQDEESKIMISDFGLS-KMEGKGDVMSTACGTPGYVAPEVLAQKPYSK 200
HRDLKPENLL S+ + + + ++DFGL+ +++G GTPGY++PEVL ++ Y K
Sbjct: 134 HRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKEAYGK 193
Query: 201 AVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDDISDSAKDFIRNLM 260
VD W+ GVI YILL GYPPF+DE+ KL++QI Y+F SP WD ++ AK+ I ++
Sbjct: 194 PVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQML 253
Query: 261 EKDPNKRYTCEQAARHPWIAGDTALNKNIHESVSAQIRKNFAKSKWRQAFNATAVVRHMR 320
+P KR T +A +HPW+ + + +H + + K FNA R ++
Sbjct: 254 TINPAKRITAHEALKHPWVCQRSTVASMMHRQETVECLKK---------FNAR---RKLK 301
Query: 321 KLHLGSSLDSSNASVSSSLSLASQKDCLAPSTLCSFISSSSGVSGVGAERRPRPTTVTAV 380
L + L + N SV + + A T + + + A+ P T T +
Sbjct: 302 GAILTTMLATRNFSVGRQTTAPATMSTAASGTTMGLVEQAKSLLNKKADGVKEPQT-TVI 360
Query: 381 HS 382
H+
Sbjct: 361 HN 362
>gi|26051216 calcium/calmodulin-dependent protein kinase II beta
isoform 7 [Homo sapiens]
Length = 479
Score = 238 bits (608), Expect = 5e-63
Identities = 128/339 (37%), Positives = 198/339 (58%), Gaps = 13/339 (3%)
Query: 23 FEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKE-SSIENEIAVLRKIKHENI 81
++ E +G GAFS V + TG +A K I K L ++ +E E + R +KH NI
Sbjct: 14 YQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKHSNI 73
Query: 82 VALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHRMGIV 141
V L D YLV LV+GGELF+ IV + +Y+E DAS I+Q+L+AV + H+MG+V
Sbjct: 74 VRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVV 133
Query: 142 HRDLKPENLLYYSQDEESKIMISDFGLS-KMEGKGDVMSTACGTPGYVAPEVLAQKPYSK 200
HRDLKPENLL S+ + + + ++DFGL+ +++G GTPGY++PEVL ++ Y K
Sbjct: 134 HRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKEAYGK 193
Query: 201 AVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDDISDSAKDFIRNLM 260
VD W+ GVI YILL GYPPF+DE+ KL++QI Y+F SP WD ++ AK+ I ++
Sbjct: 194 PVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQML 253
Query: 261 EKDPNKRYTCEQAARHPWIAGDTALNKNIHESVSAQIRKNF-AKSKWRQA---------- 309
+P KR T +A +HPW+ + + +H + + K F A+ K + A
Sbjct: 254 TINPAKRITAHEALKHPWVCQRSTVASMMHRQETVECLKKFNARRKLKGAILTTMLATRN 313
Query: 310 FNATAVVRHMRKLHLGSSLDSSNASVSSSLSLASQKDCL 348
F+A + + + + S DS+N ++ + A +++ +
Sbjct: 314 FSAAKSLLNKKADGVKESSDSANTTIEDEDAKARKQEII 352
>gi|26051204 calcium/calmodulin-dependent protein kinase II beta
isoform 1 [Homo sapiens]
Length = 666
Score = 237 bits (605), Expect = 1e-62
Identities = 129/333 (38%), Positives = 193/333 (57%), Gaps = 9/333 (2%)
Query: 23 FEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKE-SSIENEIAVLRKIKHENI 81
++ E +G GAFS V + TG +A K I K L ++ +E E + R +KH NI
Sbjct: 14 YQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKHSNI 73
Query: 82 VALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHRMGIV 141
V L D YLV LV+GGELF+ IV + +Y+E DAS I+Q+L+AV + H+MG+V
Sbjct: 74 VRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVV 133
Query: 142 HRDLKPENLLYYSQDEESKIMISDFGLS-KMEGKGDVMSTACGTPGYVAPEVLAQKPYSK 200
HRDLKPENLL S+ + + + ++DFGL+ +++G GTPGY++PEVL ++ Y K
Sbjct: 134 HRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKEAYGK 193
Query: 201 AVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDDISDSAKDFIRNLM 260
VD W+ GVI YILL GYPPF+DE+ KL++QI Y+F SP WD ++ AK+ I ++
Sbjct: 194 PVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQML 253
Query: 261 EKDPNKRYTCEQAARHPWIAGDTALNKNIHESVSAQIRKNF-AKSKWRQAFNATAVVRHM 319
+P KR T +A +HPW+ + + +H + + K F A+ K + A T +
Sbjct: 254 TINPAKRITAHEALKHPWVCQRSTVASMMHRQETVECLKKFNARRKLKGAILTTMLA--T 311
Query: 320 RKLHLGSSLDS----SNASVSSSLSLASQKDCL 348
R +G + S A+ +++ L Q L
Sbjct: 312 RNFSVGRQTTAPATMSTAASGTTMGLVEQAKSL 344
>gi|26051206 calcium/calmodulin-dependent protein kinase II beta
isoform 2 [Homo sapiens]
Length = 542
Score = 237 bits (605), Expect = 1e-62
Identities = 129/333 (38%), Positives = 193/333 (57%), Gaps = 9/333 (2%)
Query: 23 FEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKE-SSIENEIAVLRKIKHENI 81
++ E +G GAFS V + TG +A K I K L ++ +E E + R +KH NI
Sbjct: 14 YQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKHSNI 73
Query: 82 VALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHRMGIV 141
V L D YLV LV+GGELF+ IV + +Y+E DAS I+Q+L+AV + H+MG+V
Sbjct: 74 VRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVV 133
Query: 142 HRDLKPENLLYYSQDEESKIMISDFGLS-KMEGKGDVMSTACGTPGYVAPEVLAQKPYSK 200
HRDLKPENLL S+ + + + ++DFGL+ +++G GTPGY++PEVL ++ Y K
Sbjct: 134 HRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKEAYGK 193
Query: 201 AVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDDISDSAKDFIRNLM 260
VD W+ GVI YILL GYPPF+DE+ KL++QI Y+F SP WD ++ AK+ I ++
Sbjct: 194 PVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQML 253
Query: 261 EKDPNKRYTCEQAARHPWIAGDTALNKNIHESVSAQIRKNF-AKSKWRQAFNATAVVRHM 319
+P KR T +A +HPW+ + + +H + + K F A+ K + A T +
Sbjct: 254 TINPAKRITAHEALKHPWVCQRSTVASMMHRQETVECLKKFNARRKLKGAILTTMLA--T 311
Query: 320 RKLHLGSSLDS----SNASVSSSLSLASQKDCL 348
R +G + S A+ +++ L Q L
Sbjct: 312 RNFSVGRQTTAPATMSTAASGTTMGLVEQAKSL 344
>gi|26051218 calcium/calmodulin-dependent protein kinase II beta
isoform 8 [Homo sapiens]
Length = 449
Score = 237 bits (604), Expect = 2e-62
Identities = 122/294 (41%), Positives = 179/294 (60%), Gaps = 3/294 (1%)
Query: 23 FEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKE-SSIENEIAVLRKIKHENI 81
++ E +G GAFS V + TG +A K I K L ++ +E E + R +KH NI
Sbjct: 14 YQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKHSNI 73
Query: 82 VALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHRMGIV 141
V L D YLV LV+GGELF+ IV + +Y+E DAS I+Q+L+AV + H+MG+V
Sbjct: 74 VRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVV 133
Query: 142 HRDLKPENLLYYSQDEESKIMISDFGLS-KMEGKGDVMSTACGTPGYVAPEVLAQKPYSK 200
HRDLKPENLL S+ + + + ++DFGL+ +++G GTPGY++PEVL ++ Y K
Sbjct: 134 HRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKEAYGK 193
Query: 201 AVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDDISDSAKDFIRNLM 260
VD W+ GVI YILL GYPPF+DE+ KL++QI Y+F SP WD ++ AK+ I ++
Sbjct: 194 PVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQML 253
Query: 261 EKDPNKRYTCEQAARHPWIAGDTALNKNIHESVSAQIRKNF-AKSKWRQAFNAT 313
+P KR T +A +HPW+ + + +H + + K F A+ K + A T
Sbjct: 254 TINPAKRITAHEALKHPWVCQRSTVASMMHRQETVECLKKFNARRKLKGAILTT 307
>gi|149589021 doublecortin-like kinase 3 [Homo sapiens]
Length = 648
Score = 236 bits (603), Expect = 2e-62
Identities = 118/273 (43%), Positives = 175/273 (64%), Gaps = 7/273 (2%)
Query: 16 AEDIKKIFEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESSIENEIAVLRK 75
A +++K +E +G G F+ V + T + +A+K I K LKGKE +++EI +++
Sbjct: 349 AANVEKHYETGRVIGDGNFAVVKECRHRETRQAYAMKIIDKSRLKGKEDMVDSEILIIQS 408
Query: 76 IKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYYL 135
+ H NIV L ++YE+ +YL+++ V GG+LFD I+E + E DA+ +I + A+ ++
Sbjct: 409 LSHPNIVKLHEVYETDMEIYLILEYVQGGDLFDAIIESVKFPEPDAALMIMDLCKALVHM 468
Query: 136 HRMGIVHRDLKPENLLYY-SQDEESKIMISDFGLSKMEGKGDVMSTACGTPGYVAPEVLA 194
H IVHRDLKPENLL ++D+ + + ++DFGL+K + + T CGTP YVAPE+L+
Sbjct: 469 HDKSIVHRDLKPENLLVQRNEDKSTTLKLADFGLAKHVVR--PIFTVCGTPTYVAPEILS 526
Query: 195 QKPYSKAVDCWSIGVIAYILLCGYPPFY--DENDSKLFEQILKAEYEFDSPYWDDISDSA 252
+K Y VD W+ GVI YILLCG+PPF + + +LF I +EF PYWD+ISD+A
Sbjct: 527 EKGYGLEVDMWAAGVILYILLCGFPPFRSPERDQDELFNIIQLGHFEFLPPYWDNISDAA 586
Query: 253 KDFIRNLMEKDPNKRYTCEQAARHPWI--AGDT 283
KD + L+ DP KRYT Q +HPWI AG T
Sbjct: 587 KDLVSRLLVVDPKKRYTAHQVLQHPWIETAGKT 619
>gi|26667183 calcium/calmodulin-dependent protein kinase II delta
isoform 1 [Homo sapiens]
Length = 478
Score = 236 bits (602), Expect = 3e-62
Identities = 133/334 (39%), Positives = 189/334 (56%), Gaps = 9/334 (2%)
Query: 23 FEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKE-SSIENEIAVLRKIKHENI 81
++ E LG GAFS V + TG+ +A K I K L ++ +E E + R +KH NI
Sbjct: 14 YQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNI 73
Query: 82 VALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHRMGIV 141
V L D YLV LV+GGELF+ IV + +Y+E DAS I+Q+L++V + H GIV
Sbjct: 74 VRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCHLNGIV 133
Query: 142 HRDLKPENLLYYSQDEESKIMISDFGLS-KMEGKGDVMSTACGTPGYVAPEVLAQKPYSK 200
HRDLKPENLL S+ + + + ++DFGL+ +++G GTPGY++PEVL + PY K
Sbjct: 134 HRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKDPYGK 193
Query: 201 AVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDDISDSAKDFIRNLM 260
VD W+ GVI YILL GYPPF+DE+ +L++QI Y+F SP WD ++ AKD I ++
Sbjct: 194 PVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKML 253
Query: 261 EKDPNKRYTCEQAARHPWIAGDTALNKNIHESVSAQIRKNF-AKSKWRQAFNATAVVRHM 319
+P KR T +A +HPWI + + +H + K F A+ K + A T +
Sbjct: 254 TINPAKRITASEALKHPWICQRSTVASMMHRQETVDCLKKFNARRKLKGAILTTMLA--T 311
Query: 320 RKLHLGSSL----DSSNASVSSSLSLASQKDCLA 349
R SL D S SS + +D A
Sbjct: 312 RNFSAAKSLLKKPDGVKESTESSNTTIEDEDVKA 345
>gi|26667186 calcium/calmodulin-dependent protein kinase II delta
isoform 1 [Homo sapiens]
Length = 478
Score = 236 bits (602), Expect = 3e-62
Identities = 133/334 (39%), Positives = 189/334 (56%), Gaps = 9/334 (2%)
Query: 23 FEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKE-SSIENEIAVLRKIKHENI 81
++ E LG GAFS V + TG+ +A K I K L ++ +E E + R +KH NI
Sbjct: 14 YQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNI 73
Query: 82 VALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHRMGIV 141
V L D YLV LV+GGELF+ IV + +Y+E DAS I+Q+L++V + H GIV
Sbjct: 74 VRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCHLNGIV 133
Query: 142 HRDLKPENLLYYSQDEESKIMISDFGLS-KMEGKGDVMSTACGTPGYVAPEVLAQKPYSK 200
HRDLKPENLL S+ + + + ++DFGL+ +++G GTPGY++PEVL + PY K
Sbjct: 134 HRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKDPYGK 193
Query: 201 AVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDDISDSAKDFIRNLM 260
VD W+ GVI YILL GYPPF+DE+ +L++QI Y+F SP WD ++ AKD I ++
Sbjct: 194 PVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKML 253
Query: 261 EKDPNKRYTCEQAARHPWIAGDTALNKNIHESVSAQIRKNF-AKSKWRQAFNATAVVRHM 319
+P KR T +A +HPWI + + +H + K F A+ K + A T +
Sbjct: 254 TINPAKRITASEALKHPWICQRSTVASMMHRQETVDCLKKFNARRKLKGAILTTMLA--T 311
Query: 320 RKLHLGSSL----DSSNASVSSSLSLASQKDCLA 349
R SL D S SS + +D A
Sbjct: 312 RNFSAAKSLLKKPDGVKESTESSNTTIEDEDVKA 345
>gi|26667189 calcium/calmodulin-dependent protein kinase II delta
isoform 2 [Homo sapiens]
Length = 478
Score = 236 bits (602), Expect = 3e-62
Identities = 133/334 (39%), Positives = 189/334 (56%), Gaps = 9/334 (2%)
Query: 23 FEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKE-SSIENEIAVLRKIKHENI 81
++ E LG GAFS V + TG+ +A K I K L ++ +E E + R +KH NI
Sbjct: 14 YQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNI 73
Query: 82 VALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHRMGIV 141
V L D YLV LV+GGELF+ IV + +Y+E DAS I+Q+L++V + H GIV
Sbjct: 74 VRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCHLNGIV 133
Query: 142 HRDLKPENLLYYSQDEESKIMISDFGLS-KMEGKGDVMSTACGTPGYVAPEVLAQKPYSK 200
HRDLKPENLL S+ + + + ++DFGL+ +++G GTPGY++PEVL + PY K
Sbjct: 134 HRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKDPYGK 193
Query: 201 AVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDDISDSAKDFIRNLM 260
VD W+ GVI YILL GYPPF+DE+ +L++QI Y+F SP WD ++ AKD I ++
Sbjct: 194 PVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKML 253
Query: 261 EKDPNKRYTCEQAARHPWIAGDTALNKNIHESVSAQIRKNF-AKSKWRQAFNATAVVRHM 319
+P KR T +A +HPWI + + +H + K F A+ K + A T +
Sbjct: 254 TINPAKRITASEALKHPWICQRSTVASMMHRQETVDCLKKFNARRKLKGAILTTMLA--T 311
Query: 320 RKLHLGSSL----DSSNASVSSSLSLASQKDCLA 349
R SL D S SS + +D A
Sbjct: 312 RNFSAAKSLLKKPDGVKESTESSNTTIEDEDVKA 345
>gi|26667180 calcium/calmodulin-dependent protein kinase II delta
isoform 3 [Homo sapiens]
Length = 499
Score = 236 bits (602), Expect = 3e-62
Identities = 133/334 (39%), Positives = 189/334 (56%), Gaps = 9/334 (2%)
Query: 23 FEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKE-SSIENEIAVLRKIKHENI 81
++ E LG GAFS V + TG+ +A K I K L ++ +E E + R +KH NI
Sbjct: 14 YQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNI 73
Query: 82 VALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHRMGIV 141
V L D YLV LV+GGELF+ IV + +Y+E DAS I+Q+L++V + H GIV
Sbjct: 74 VRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCHLNGIV 133
Query: 142 HRDLKPENLLYYSQDEESKIMISDFGLS-KMEGKGDVMSTACGTPGYVAPEVLAQKPYSK 200
HRDLKPENLL S+ + + + ++DFGL+ +++G GTPGY++PEVL + PY K
Sbjct: 134 HRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKDPYGK 193
Query: 201 AVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDDISDSAKDFIRNLM 260
VD W+ GVI YILL GYPPF+DE+ +L++QI Y+F SP WD ++ AKD I ++
Sbjct: 194 PVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKML 253
Query: 261 EKDPNKRYTCEQAARHPWIAGDTALNKNIHESVSAQIRKNF-AKSKWRQAFNATAVVRHM 319
+P KR T +A +HPWI + + +H + K F A+ K + A T +
Sbjct: 254 TINPAKRITASEALKHPWICQRSTVASMMHRQETVDCLKKFNARRKLKGAILTTMLA--T 311
Query: 320 RKLHLGSSL----DSSNASVSSSLSLASQKDCLA 349
R SL D S SS + +D A
Sbjct: 312 RNFSAAKSLLKKPDGVKESTESSNTTIEDEDVKA 345
>gi|26667199 calcium/calmodulin-dependent protein kinase II gamma
isoform 3 [Homo sapiens]
Length = 518
Score = 236 bits (601), Expect = 3e-62
Identities = 123/297 (41%), Positives = 183/297 (61%), Gaps = 3/297 (1%)
Query: 23 FEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKE-SSIENEIAVLRKIKHENI 81
++ E LG GAFS V +K + + +A K I K L ++ +E E + R +KH NI
Sbjct: 14 YQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNI 73
Query: 82 VALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHRMGIV 141
V L D YLV LV+GGELF+ IV + +Y+E DAS I Q+L++V ++H+ IV
Sbjct: 74 VRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQHDIV 133
Query: 142 HRDLKPENLLYYSQDEESKIMISDFGLS-KMEGKGDVMSTACGTPGYVAPEVLAQKPYSK 200
HRDLKPENLL S+ + + + ++DFGL+ +++G+ GTPGY++PEVL + PY K
Sbjct: 134 HRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRKDPYGK 193
Query: 201 AVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDDISDSAKDFIRNLM 260
VD W+ GVI YILL GYPPF+DE+ KL++QI Y+F SP WD ++ AK+ I ++
Sbjct: 194 PVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQML 253
Query: 261 EKDPNKRYTCEQAARHPWIAGDTALNKNIHESVSAQ-IRKNFAKSKWRQAFNATAVV 316
+P KR T +QA +HPW+ + + +H + + +RK A+ K + A T +V
Sbjct: 254 TINPAKRITADQALKHPWVCQRSTVASMMHRQETVECLRKFNARRKLKGAILTTMLV 310
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.131 0.377
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 14,200,703
Number of Sequences: 37866
Number of extensions: 595607
Number of successful extensions: 4451
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 600
Number of HSP's successfully gapped in prelim test: 217
Number of HSP's that attempted gapping in prelim test: 1963
Number of HSP's gapped (non-prelim): 980
length of query: 385
length of database: 18,247,518
effective HSP length: 104
effective length of query: 281
effective length of database: 14,309,454
effective search space: 4020956574
effective search space used: 4020956574
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.