Search of human proteins with 237858682

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|237858682 neurofascin isoform 6 precursor [Homo sapiens]
         (613 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|237858682 neurofascin isoform 6 precursor [Homo sapiens]          1269   0.0  
gi|237858680 neurofascin isoform 5 precursor [Homo sapiens]          1262   0.0  
gi|237858675 neurofascin isoform 1 precursor [Homo sapiens]          1237   0.0  
gi|237858679 neurofascin isoform 3 precursor [Homo sapiens]          1233   0.0  
gi|89903008 neurofascin isoform 4 precursor [Homo sapiens]           1233   0.0  
gi|237858677 neurofascin isoform 2 precursor [Homo sapiens]          1231   0.0  
gi|81158224 neuronal cell adhesion molecule isoform B precursor ...   667   0.0  
gi|81158226 neuronal cell adhesion molecule isoform A precursor ...   662   0.0  
gi|221316760 L1 cell adhesion molecule isoform 3 precursor [Homo...   459   e-129
gi|13435353 L1 cell adhesion molecule isoform 2 precursor [Homo ...   452   e-127
gi|4557707 L1 cell adhesion molecule isoform 1 precursor [Homo s...   452   e-127
gi|27894376 cell adhesion molecule with homology to L1CAM precur...   412   e-115
gi|28373129 contactin 5 isoform short [Homo sapiens]                  245   8e-65
gi|7657359 contactin 5 isoform long [Homo sapiens]                    244   2e-64
gi|28373122 contactin 4 isoform a precursor [Homo sapiens]            234   1e-61
gi|75709184 contactin 3 [Homo sapiens]                                226   4e-59
gi|4827022 contactin 2 precursor [Homo sapiens]                       226   5e-59
gi|28373117 contactin 1 isoform 1 precursor [Homo sapiens]            219   4e-57
gi|28373119 contactin 1 isoform 2 precursor [Homo sapiens]            219   4e-57
gi|7657361 contactin 6 [Homo sapiens]                                 198   1e-50
gi|193083163 roundabout, axon guidance receptor, homolog 2 isofo...   192   1e-48
gi|61888896 roundabout, axon guidance receptor, homolog 2 isofor...   192   1e-48
gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens]                   182   6e-46
gi|118572606 hemicentin 1 [Homo sapiens]                              182   1e-45
gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens]                   181   1e-45
gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens]                   181   1e-45
gi|48476182 roundabout, axon guidance receptor, homolog 3 [Homo ...   179   5e-45
gi|19743806 roundabout 1 isoform b [Homo sapiens]                     176   6e-44
gi|4506569 roundabout 1 isoform a [Homo sapiens]                      176   6e-44
gi|224994173 roundabout 1 isoform d [Homo sapiens]                    171   1e-42

>gi|237858682 neurofascin isoform 6 precursor [Homo sapiens]
          Length = 613

 Score = 1269 bits (3283), Expect = 0.0
 Identities = 613/613 (100%), Positives = 613/613 (100%)

Query: 1   MARQPPPPWVHAAFLLCLLSLGGAIEIPMDLTQPPTITKQSAKDHIVDPRDNILIECEAK 60
           MARQPPPPWVHAAFLLCLLSLGGAIEIPMDLTQPPTITKQSAKDHIVDPRDNILIECEAK
Sbjct: 1   MARQPPPPWVHAAFLLCLLSLGGAIEIPMDLTQPPTITKQSAKDHIVDPRDNILIECEAK 60

Query: 61  GNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGT 120
           GNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGT
Sbjct: 61  GNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGT 120

Query: 121 ALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQD 180
           ALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQD
Sbjct: 121 ALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQD 180

Query: 181 KRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSF 240
           KRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSF
Sbjct: 181 KRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSF 240

Query: 241 MYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNV 300
           MYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNV
Sbjct: 241 MYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNV 300

Query: 301 SEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRANGNPKP 360
           SEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRANGNPKP
Sbjct: 301 SEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRANGNPKP 360

Query: 361 TVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVL 420
           TVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVL
Sbjct: 361 TVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVL 420

Query: 421 DVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSL 480
           DVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSL
Sbjct: 421 DVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSL 480

Query: 481 EIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVK 540
           EIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVK
Sbjct: 481 EIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVK 540

Query: 541 HDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAERDQGSYTCVASTELDQDLAKAY 600
           HDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAERDQGSYTCVASTELDQDLAKAY
Sbjct: 541 HDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAERDQGSYTCVASTELDQDLAKAY 600

Query: 601 LTVLGNCPCSPWH 613
           LTVLGNCPCSPWH
Sbjct: 601 LTVLGNCPCSPWH 613


>gi|237858680 neurofascin isoform 5 precursor [Homo sapiens]
          Length = 619

 Score = 1262 bits (3266), Expect = 0.0
 Identities = 613/619 (99%), Positives = 613/619 (99%), Gaps = 6/619 (0%)

Query: 1   MARQPPPPWVHAAFLLCLLSLGGAIEIPMD------LTQPPTITKQSAKDHIVDPRDNIL 54
           MARQPPPPWVHAAFLLCLLSLGGAIEIPMD      LTQPPTITKQSAKDHIVDPRDNIL
Sbjct: 1   MARQPPPPWVHAAFLLCLLSLGGAIEIPMDPSIQNELTQPPTITKQSAKDHIVDPRDNIL 60

Query: 55  IECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFA 114
           IECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFA
Sbjct: 61  IECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFA 120

Query: 115 RNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSM 174
           RNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSM
Sbjct: 121 RNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSM 180

Query: 175 EPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRGVA 234
           EPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRGVA
Sbjct: 181 EPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRGVA 240

Query: 235 ERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKA 294
           ERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKA
Sbjct: 241 ERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKA 300

Query: 295 LRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRA 354
           LRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRA
Sbjct: 301 LRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRA 360

Query: 355 NGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLAN 414
           NGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLAN
Sbjct: 361 NGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLAN 420

Query: 415 AFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHV 474
           AFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHV
Sbjct: 421 AFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHV 480

Query: 475 YENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTVQ 534
           YENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTVQ
Sbjct: 481 YENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTVQ 540

Query: 535 LECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAERDQGSYTCVASTELDQ 594
           LECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAERDQGSYTCVASTELDQ
Sbjct: 541 LECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAERDQGSYTCVASTELDQ 600

Query: 595 DLAKAYLTVLGNCPCSPWH 613
           DLAKAYLTVLGNCPCSPWH
Sbjct: 601 DLAKAYLTVLGNCPCSPWH 619


>gi|237858675 neurofascin isoform 1 precursor [Homo sapiens]
          Length = 1240

 Score = 1237 bits (3200), Expect = 0.0
 Identities = 604/612 (98%), Positives = 605/612 (98%), Gaps = 6/612 (0%)

Query: 1   MARQPPPPWVHAAFLLCLLSLGGAIEIPMD------LTQPPTITKQSAKDHIVDPRDNIL 54
           MARQPPPPWVHAAFLLCLLSLGGAIEIPMD      LTQPPTITKQSAKDHIVDPRDNIL
Sbjct: 1   MARQPPPPWVHAAFLLCLLSLGGAIEIPMDPSIQNELTQPPTITKQSAKDHIVDPRDNIL 60

Query: 55  IECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFA 114
           IECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFA
Sbjct: 61  IECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFA 120

Query: 115 RNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSM 174
           RNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSM
Sbjct: 121 RNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSM 180

Query: 175 EPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRGVA 234
           EPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRGVA
Sbjct: 181 EPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRGVA 240

Query: 235 ERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKA 294
           ERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKA
Sbjct: 241 ERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKA 300

Query: 295 LRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRA 354
           LRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRA
Sbjct: 301 LRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRA 360

Query: 355 NGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLAN 414
           NGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLAN
Sbjct: 361 NGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLAN 420

Query: 415 AFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHV 474
           AFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHV
Sbjct: 421 AFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHV 480

Query: 475 YENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTVQ 534
           YENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTVQ
Sbjct: 481 YENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTVQ 540

Query: 535 LECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAERDQGSYTCVASTELDQ 594
           LECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAERDQGSYTCVASTELDQ
Sbjct: 541 LECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAERDQGSYTCVASTELDQ 600

Query: 595 DLAKAYLTVLGN 606
           DLAKAYLTVL +
Sbjct: 601 DLAKAYLTVLAD 612


>gi|237858679 neurofascin isoform 3 precursor [Homo sapiens]
          Length = 1174

 Score = 1233 bits (3189), Expect = 0.0
 Identities = 604/622 (97%), Positives = 604/622 (97%), Gaps = 17/622 (2%)

Query: 1   MARQPPPPWVHAAFLLCLLSLGGAIEIPMDLTQPPTITKQSAKDHIVDPRDNILIECEAK 60
           MARQPPPPWVHAAFLLCLLSLGGAIEIPMDLTQPPTITKQSAKDHIVDPRDNILIECEAK
Sbjct: 1   MARQPPPPWVHAAFLLCLLSLGGAIEIPMDLTQPPTITKQSAKDHIVDPRDNILIECEAK 60

Query: 61  GNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGT 120
           GNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGT
Sbjct: 61  GNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGT 120

Query: 121 ALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQD 180
           ALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQD
Sbjct: 121 ALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQD 180

Query: 181 KRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTT---------- 230
           KRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLT           
Sbjct: 181 KRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTNHPYNDSSLRN 240

Query: 231 -------RGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPS 283
                  RGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPS
Sbjct: 241 HPDMYSARGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPS 300

Query: 284 DKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILA 343
           DKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILA
Sbjct: 301 DKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILA 360

Query: 344 PGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCN 403
           PGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCN
Sbjct: 361 PGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCN 420

Query: 404 TSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQ 463
           TSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQ
Sbjct: 421 TSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQ 480

Query: 464 GSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPE 523
           GSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPE
Sbjct: 481 GSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPE 540

Query: 524 DQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAERDQGS 583
           DQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAERDQGS
Sbjct: 541 DQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAERDQGS 600

Query: 584 YTCVASTELDQDLAKAYLTVLG 605
           YTCVASTELDQDLAKAYLTVLG
Sbjct: 601 YTCVASTELDQDLAKAYLTVLG 622



 Score = 98.2 bits (243), Expect = 2e-20
 Identities = 96/390 (24%), Positives = 156/390 (40%), Gaps = 53/390 (13%)

Query: 52  NILIECEAKGNPAPSFHWTRN--------SRFFNIAKDPRVSMRRRSGTLVIDFRSGGRP 103
           ++L+EC A G P P   W +         ++F N  K  R++                  
Sbjct: 274 DLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRIT---------------NVS 318

Query: 104 EEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQ-EGAPLTLQCNPPPGL 162
           EE  GEY C A NK G+ + + I ++V  +P W  E  + ++   E   L  + N   G 
Sbjct: 319 EEDSGEYFCLASNKMGS-IRHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRAN---GN 374

Query: 163 PSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTD----YSCNARFHFTHTIQ 218
           P P + WM +  EP+   +      N ++    ++ +D Q      Y CN      H   
Sbjct: 375 PKPTVQWMVNG-EPL---QSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNE--HGYL 428

Query: 219 QKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKG 278
             N F         V +  P  + P+      ++     L  +C   G P P + W+K G
Sbjct: 429 LANAFV-------SVLDVPPRMLSPRNQLIRVILYNRTRL--DCPFFGSPIPTLRWFKNG 479

Query: 279 GDLPSDKAKFENF-NKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEP 337
                D   +  + N +L I  + +ED G Y C+A+N +G   + + + VK        P
Sbjct: 480 QGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMP 539

Query: 338 KNLILAPGEDGRLVCRANGNP--KPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQIS 395
           ++ +   G   +L CR   +P  K TV W+ + EPL         +   D++        
Sbjct: 540 EDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKED---DSLTIFGVAER 596

Query: 396 SRAVYQCNTSNEHGYLLANAFVSVLDVPPR 425
            +  Y C  S E    LA A+++VL  P R
Sbjct: 597 DQGSYTCVASTELDQDLAKAYLTVLGRPDR 626


>gi|89903008 neurofascin isoform 4 precursor [Homo sapiens]
          Length = 1169

 Score = 1233 bits (3189), Expect = 0.0
 Identities = 604/622 (97%), Positives = 604/622 (97%), Gaps = 17/622 (2%)

Query: 1   MARQPPPPWVHAAFLLCLLSLGGAIEIPMDLTQPPTITKQSAKDHIVDPRDNILIECEAK 60
           MARQPPPPWVHAAFLLCLLSLGGAIEIPMDLTQPPTITKQSAKDHIVDPRDNILIECEAK
Sbjct: 1   MARQPPPPWVHAAFLLCLLSLGGAIEIPMDLTQPPTITKQSAKDHIVDPRDNILIECEAK 60

Query: 61  GNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGT 120
           GNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGT
Sbjct: 61  GNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGT 120

Query: 121 ALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQD 180
           ALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQD
Sbjct: 121 ALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQD 180

Query: 181 KRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTT---------- 230
           KRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLT           
Sbjct: 181 KRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTNHPYNDSSLRN 240

Query: 231 -------RGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPS 283
                  RGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPS
Sbjct: 241 HPDMYSARGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPS 300

Query: 284 DKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILA 343
           DKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILA
Sbjct: 301 DKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILA 360

Query: 344 PGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCN 403
           PGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCN
Sbjct: 361 PGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCN 420

Query: 404 TSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQ 463
           TSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQ
Sbjct: 421 TSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQ 480

Query: 464 GSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPE 523
           GSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPE
Sbjct: 481 GSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPE 540

Query: 524 DQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAERDQGS 583
           DQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAERDQGS
Sbjct: 541 DQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAERDQGS 600

Query: 584 YTCVASTELDQDLAKAYLTVLG 605
           YTCVASTELDQDLAKAYLTVLG
Sbjct: 601 YTCVASTELDQDLAKAYLTVLG 622



 Score = 98.2 bits (243), Expect = 2e-20
 Identities = 96/390 (24%), Positives = 156/390 (40%), Gaps = 53/390 (13%)

Query: 52  NILIECEAKGNPAPSFHWTRN--------SRFFNIAKDPRVSMRRRSGTLVIDFRSGGRP 103
           ++L+EC A G P P   W +         ++F N  K  R++                  
Sbjct: 274 DLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRIT---------------NVS 318

Query: 104 EEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQ-EGAPLTLQCNPPPGL 162
           EE  GEY C A NK G+ + + I ++V  +P W  E  + ++   E   L  + N   G 
Sbjct: 319 EEDSGEYFCLASNKMGS-IRHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRAN---GN 374

Query: 163 PSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTD----YSCNARFHFTHTIQ 218
           P P + WM +  EP+   +      N ++    ++ +D Q      Y CN      H   
Sbjct: 375 PKPTVQWMVNG-EPL---QSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNE--HGYL 428

Query: 219 QKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKG 278
             N F         V +  P  + P+      ++     L  +C   G P P + W+K G
Sbjct: 429 LANAFV-------SVLDVPPRMLSPRNQLIRVILYNRTRL--DCPFFGSPIPTLRWFKNG 479

Query: 279 GDLPSDKAKFENF-NKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEP 337
                D   +  + N +L I  + +ED G Y C+A+N +G   + + + VK        P
Sbjct: 480 QGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMP 539

Query: 338 KNLILAPGEDGRLVCRANGNP--KPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQIS 395
           ++ +   G   +L CR   +P  K TV W+ + EPL         +   D++        
Sbjct: 540 EDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKED---DSLTIFGVAER 596

Query: 396 SRAVYQCNTSNEHGYLLANAFVSVLDVPPR 425
            +  Y C  S E    LA A+++VL  P R
Sbjct: 597 DQGSYTCVASTELDQDLAKAYLTVLGRPDR 626


>gi|237858677 neurofascin isoform 2 precursor [Homo sapiens]
          Length = 1189

 Score = 1231 bits (3184), Expect = 0.0
 Identities = 603/623 (96%), Positives = 604/623 (96%), Gaps = 17/623 (2%)

Query: 1   MARQPPPPWVHAAFLLCLLSLGGAIEIPMDLTQPPTITKQSAKDHIVDPRDNILIECEAK 60
           MARQPPPPWVHAAFLLCLLSLGGAIEIPMDLTQPPTITKQSAKDHIVDPRDNILIECEAK
Sbjct: 1   MARQPPPPWVHAAFLLCLLSLGGAIEIPMDLTQPPTITKQSAKDHIVDPRDNILIECEAK 60

Query: 61  GNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGT 120
           GNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGT
Sbjct: 61  GNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGT 120

Query: 121 ALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQD 180
           ALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQD
Sbjct: 121 ALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQD 180

Query: 181 KRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTT---------- 230
           KRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLT           
Sbjct: 181 KRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTNHPYNDSSLRN 240

Query: 231 -------RGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPS 283
                  RGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPS
Sbjct: 241 HPDMYSARGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPS 300

Query: 284 DKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILA 343
           DKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILA
Sbjct: 301 DKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILA 360

Query: 344 PGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCN 403
           PGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCN
Sbjct: 361 PGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCN 420

Query: 404 TSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQ 463
           TSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQ
Sbjct: 421 TSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQ 480

Query: 464 GSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPE 523
           GSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPE
Sbjct: 481 GSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPE 540

Query: 524 DQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAERDQGS 583
           DQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAERDQGS
Sbjct: 541 DQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAERDQGS 600

Query: 584 YTCVASTELDQDLAKAYLTVLGN 606
           YTCVASTELDQDLAKAYLTVL +
Sbjct: 601 YTCVASTELDQDLAKAYLTVLAD 623


>gi|81158224 neuronal cell adhesion molecule isoform B precursor
           [Homo sapiens]
          Length = 1183

 Score =  667 bits (1721), Expect = 0.0
 Identities = 324/609 (53%), Positives = 425/609 (69%), Gaps = 19/609 (3%)

Query: 15  LLCLLSLGGAIEIPMDLTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSR 74
           +L L  +  A+E+P+DL QPPTIT+QS KD+I+DPR+NI+I+CEAKG P PSF WTRN  
Sbjct: 20  ILFLCQMISALEVPLDLVQPPTITQQSPKDYIIDPRENIVIQCEAKGKPPPSFSWTRNGT 79

Query: 75  FFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSP 134
            F+I KDP V+M+  +GTL+I+  S G+ E YEG YQC ARN+ G A+SN I ++ S+SP
Sbjct: 80  HFDIDKDPLVTMKPGTGTLIINIMSEGKAETYEGVYQCTARNERGAAVSNNIVVRPSRSP 139

Query: 135 LWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFS 194
           LW KE L+P+ +Q G  L L C PP GLP P+IFWM +S + + Q +RVSQG NGDLYFS
Sbjct: 140 LWTKEKLEPITLQSGQSLVLPCRPPIGLPPPIIFWMDNSFQRLPQSERVSQGLNGDLYFS 199

Query: 195 NVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTT-------------------RGVAE 235
           NV+ +D + DY C ARF+ T TIQQK P ++KV++                    +   E
Sbjct: 200 NVLPEDTREDYICYARFNHTQTIQQKQPISVKVISVDELNDTIAANLSDTEFYGAKSSRE 259

Query: 236 RTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKAL 295
           R P+F+ P+G AS++  LRG  L LECIA G+PTP I W K+ G LP ++  ++NF K L
Sbjct: 260 RPPTFLTPEGNASNKEELRGNVLSLECIAEGLPTPIIYWAKEDGMLPKNRTVYKNFEKTL 319

Query: 296 RITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRAN 355
           +I +VSE DSG Y C+A N +G+I HTISVRVKAAPYW+  P+NL+L+PGEDG L+CRAN
Sbjct: 320 QIIHVSEADSGNYQCIAKNALGAIHHTISVRVKAAPYWITAPQNLVLSPGEDGTLICRAN 379

Query: 356 GNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANA 415
           GNPKP + W+ NG P++ AP +P+R++ GDTIIF + Q  S AVYQCN SNE+GYLLANA
Sbjct: 380 GNPKPRISWLTNGVPIEIAPDDPSRKIDGDTIIFSNVQERSSAVYQCNASNEYGYLLANA 439

Query: 416 FVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVY 475
           FV+VL  PPR+L+P N L +VI      LDC FFGSP+PT+ WFK  +GS L    Y ++
Sbjct: 440 FVNVLAEPPRILTPANTLYQVIANRPALLDCAFFGSPLPTIEWFKGAKGSALHEDIYVLH 499

Query: 476 ENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTVQL 535
           ENG+LEI + +K+  G YTCVA N LG A+N+V LE+KDPT I + PE  V +RG+ V  
Sbjct: 500 ENGTLEIPVAQKDSTGTYTCVARNKLGMAKNEVHLEIKDPTWIVKQPEYAVVQRGSMVSF 559

Query: 536 ECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAERDQGSYTCVASTELDQD 595
           EC+VKHD +L LTV WLKD+  L    R   + D L +  V++ D G+YTCVA+T LD  
Sbjct: 560 ECKVKHDHTLSLTVLWLKDNRELPSDERFTVDKDHLVVADVSDDDSGTYTCVANTTLDSV 619

Query: 596 LAKAYLTVL 604
            A A L+V+
Sbjct: 620 SASAVLSVV 628



 Score =  109 bits (272), Expect = 8e-24
 Identities = 106/400 (26%), Positives = 169/400 (42%), Gaps = 37/400 (9%)

Query: 33  QPPT-ITKQSAKDHIVDPRDNIL-IECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRS 90
           +PPT +T +    +  + R N+L +EC A+G P P  +W +      +    R   +   
Sbjct: 260 RPPTFLTPEGNASNKEELRGNVLSLECIAEGLPTPIIYWAKED---GMLPKNRTVYKNFE 316

Query: 91  GTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLW--PKENLDPVVVQE 148
            TL I   S    E   G YQC A+N  G A+ + I ++V  +P W    +NL   V+  
Sbjct: 317 KTLQIIHVS----EADSGNYQCIAKNALG-AIHHTISVRVKAAPYWITAPQNL---VLSP 368

Query: 149 GAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGD-LYFSNVMLQDMQTDYSC 207
           G   TL C    G P P I W+++ +         S+  +GD + FSNV  +     Y C
Sbjct: 369 GEDGTLICRAN-GNPKPRISWLTNGVPIEIAPDDPSRKIDGDTIIFSNVQERSSAV-YQC 426

Query: 208 NARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGV 267
           NA   + + +   N F         V    P  + P  T     V+     LL+C   G 
Sbjct: 427 NASNEYGYLLA--NAFV-------NVLAEPPRILTPANTL--YQVIANRPALLDCAFFGS 475

Query: 268 PTPDIAWYK--KGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISV 325
           P P I W+K  KG  L  D       N  L I    ++ +G Y C+A NK+G  ++ + +
Sbjct: 476 PLPTIEWFKGAKGSALHEDIYVLHE-NGTLEIPVAQKDSTGTYTCVARNKLGMAKNEVHL 534

Query: 326 RVKAAPYWLDEPKNLILAPGEDGRLVCRANGNP--KPTVQWMVNGEPLQSAPPNPNREVA 383
            +K   + + +P+  ++  G      C+   +     TV W+ +   L   P +    V 
Sbjct: 535 EIKDPTWIVKQPEYAVVQRGSMVSFECKVKHDHTLSLTVLWLKDNREL---PSDERFTVD 591

Query: 384 GDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVP 423
            D ++  D        Y C  +     + A+A +SV+DVP
Sbjct: 592 KDHLVVADVSDDDSGTYTCVANTTLDSVSASAVLSVVDVP 631



 Score = 76.3 bits (186), Expect = 8e-14
 Identities = 119/525 (22%), Positives = 193/525 (36%), Gaps = 73/525 (13%)

Query: 32  TQPPTITKQSAKDHIVDPRDNILIECEAK-GNPAPSFHWTRNSRFFNIAKDPRVSMRRRS 90
           ++ P  TK+  +   +    ++++ C    G P P   W  NS F  + +  RVS +  +
Sbjct: 136 SRSPLWTKEKLEPITLQSGQSLVLPCRPPIGLPPPIIFWMDNS-FQRLPQSERVS-QGLN 193

Query: 91  GTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQV-------------------- 130
           G L   + S   PE+   +Y C+AR      +  +  + V                    
Sbjct: 194 GDL---YFSNVLPEDTREDYICYARFNHTQTIQQKQPISVKVISVDELNDTIAANLSDTE 250

Query: 131 ---SKSP-------LWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQD 180
              +KS        L P+ N        G  L+L+C    GLP+P+I+W       + ++
Sbjct: 251 FYGAKSSRERPPTFLTPEGNASNKEELRGNVLSLECIAE-GLPTPIIYWAKED-GMLPKN 308

Query: 181 KRVSQGHNGDLYFSNVMLQDMQTDYSC---NARFHFTHTIQQKNPFTLKVLTTRGVAERT 237
           + V +     L   +V   D   +Y C   NA     HTI  +              +  
Sbjct: 309 RTVYKNFEKTLQIIHVSEAD-SGNYQCIAKNALGAIHHTISVR-------------VKAA 354

Query: 238 PSFMYPQGTASSQMVLR-GMDLLLECIASGVPTPDIAWYKKGGDL---PSDKAKFENFNK 293
           P ++    TA   +VL  G D  L C A+G P P I+W   G  +   P D ++  + + 
Sbjct: 355 PYWI----TAPQNLVLSPGEDGTLICRANGNPKPRISWLTNGVPIEIAPDDPSRKIDGDT 410

Query: 294 ALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLI--LAPGEDGRLV 351
            +  +NV E  S  Y C ASN+ G +     V V A P  +  P N +  +       L 
Sbjct: 411 II-FSNVQERSSAVYQCNASNEYGYLLANAFVNVLAEPPRILTPANTLYQVIANRPALLD 469

Query: 352 CRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYL 411
           C   G+P PT++W   G    +   +        T+     Q  S   Y C   N+ G  
Sbjct: 470 CAFFGSPLPTIEWF-KGAKGSALHEDIYVLHENGTLEIPVAQKDSTGTYTCVARNKLGMA 528

Query: 412 LANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLR--WFKNGQGSNLDG 469
                + + D  P  +  + +   V   +    +C        +L   W K+ +   L  
Sbjct: 529 KNEVHLEIKD--PTWIVKQPEYAVVQRGSMVSFECKVKHDHTLSLTVLWLKDNR--ELPS 584

Query: 470 GNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKD 514
                 +   L +  +  +D G YTCVA   L        L V D
Sbjct: 585 DERFTVDKDHLVVADVSDDDSGTYTCVANTTLDSVSASAVLSVVD 629



 Score = 73.6 bits (179), Expect = 5e-13
 Identities = 86/343 (25%), Positives = 133/343 (38%), Gaps = 45/343 (13%)

Query: 46  IVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEE 105
           ++ P ++  + C A GNP P   W  N     IA D     R+  G  +I        E 
Sbjct: 365 VLSPGEDGTLICRANGNPKPRISWLTNGVPIEIAPDD--PSRKIDGDTII---FSNVQER 419

Query: 106 YEGEYQCFARNKFGTALSNRIRLQVSKSP--LWPKENLDPVVVQEGAPLTLQCNPPPGLP 163
               YQC A N++G  L+N     +++ P  L P   L  V+     P  L C    G P
Sbjct: 420 SSAVYQCNASNEYGYLLANAFVNVLAEPPRILTPANTLYQVIANR--PALLDC-AFFGSP 476

Query: 164 SPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPF 223
            P I W   +      +       NG L    V  +D    Y+C AR         KN  
Sbjct: 477 LPTIEWFKGAKGSALHEDIYVLHENGTLEIP-VAQKDSTGTYTCVARNKLG---MAKNEV 532

Query: 224 TLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIA--WYKKGGDL 281
            L++        + P+++  Q   +  +V RG  +  EC      T  +   W K   +L
Sbjct: 533 HLEI--------KDPTWIVKQPEYA--VVQRGSMVSFECKVKHDHTLSLTVLWLKDNREL 582

Query: 282 PSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPY--------- 332
           PSD+ +F      L + +VS++DSG Y C+A+  + S+  +  + V   P          
Sbjct: 583 PSDE-RFTVDKDHLVVADVSDDDSGTYTCVANTTLDSVSASAVLSVVDVPNPPFDLELTD 641

Query: 333 WLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAP 375
            LD+   L   PG+D         N  P  ++++  E     P
Sbjct: 642 QLDKSVQLSWTPGDD---------NNSPITKFIIEYEDAMHKP 675


>gi|81158226 neuronal cell adhesion molecule isoform A precursor
           [Homo sapiens]
          Length = 1304

 Score =  662 bits (1708), Expect = 0.0
 Identities = 325/619 (52%), Positives = 426/619 (68%), Gaps = 25/619 (4%)

Query: 15  LLCLLSLGGAIEIPMD------LTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFH 68
           +L L  +  A+E+P+D      L QPPTIT+QS KD+I+DPR+NI+I+CEAKG P PSF 
Sbjct: 20  ILFLCQMISALEVPLDPKLLEDLVQPPTITQQSPKDYIIDPRENIVIQCEAKGKPPPSFS 79

Query: 69  WTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRL 128
           WTRN   F+I KDP V+M+  +GTL+I+  S G+ E YEG YQC ARN+ G A+SN I +
Sbjct: 80  WTRNGTHFDIDKDPLVTMKPGTGTLIINIMSEGKAETYEGVYQCTARNERGAAVSNNIVV 139

Query: 129 QVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHN 188
           + S+SPLW KE L+P+ +Q G  L L C PP GLP P+IFWM +S + + Q +RVSQG N
Sbjct: 140 RPSRSPLWTKEKLEPITLQSGQSLVLPCRPPIGLPPPIIFWMDNSFQRLPQSERVSQGLN 199

Query: 189 GDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTT------------------ 230
           GDLYFSNV+ +D + DY C ARF+ T TIQQK P ++KV++                   
Sbjct: 200 GDLYFSNVLPEDTREDYICYARFNHTQTIQQKQPISVKVISVDELNDTIAANLSDTEFYG 259

Query: 231 -RGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFE 289
            +   ER P+F+ P+G AS++  LRG  L LECIA G+PTP I W K+ G LP ++  ++
Sbjct: 260 AKSSRERPPTFLTPEGNASNKEELRGNVLSLECIAEGLPTPIIYWAKEDGMLPKNRTVYK 319

Query: 290 NFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDGR 349
           NF K L+I +VSE DSG Y C+A N +G+I HTISVRVKAAPYW+  P+NL+L+PGEDG 
Sbjct: 320 NFEKTLQIIHVSEADSGNYQCIAKNALGAIHHTISVRVKAAPYWITAPQNLVLSPGEDGT 379

Query: 350 LVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHG 409
           L+CRANGNPKP + W+ NG P++ AP +P+R++ GDTIIF + Q  S AVYQCN SNE+G
Sbjct: 380 LICRANGNPKPRISWLTNGVPIEIAPDDPSRKIDGDTIIFSNVQERSSAVYQCNASNEYG 439

Query: 410 YLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDG 469
           YLLANAFV+VL  PPR+L+P N L +VI      LDC FFGSP+PT+ WFK  +GS L  
Sbjct: 440 YLLANAFVNVLAEPPRILTPANTLYQVIANRPALLDCAFFGSPLPTIEWFKGAKGSALHE 499

Query: 470 GNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVARR 529
             Y ++ENG+LEI + +K+  G YTCVA N LG A+N+V LE+KDPT I + PE  V +R
Sbjct: 500 DIYVLHENGTLEIPVAQKDSTGTYTCVARNKLGMAKNEVHLEIKDPTWIVKQPEYAVVQR 559

Query: 530 GTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAERDQGSYTCVAS 589
           G+ V  EC+VKHD +L LTV WLKD+  L    R   + D L +  V++ D G+YTCVA+
Sbjct: 560 GSMVSFECKVKHDHTLSLTVLWLKDNRELPSDERFTVDKDHLVVADVSDDDSGTYTCVAN 619

Query: 590 TELDQDLAKAYLTVLGNCP 608
           T LD   A A L+V+   P
Sbjct: 620 TTLDSVSASAVLSVVAPTP 638


>gi|221316760 L1 cell adhesion molecule isoform 3 precursor [Homo
           sapiens]
          Length = 1248

 Score =  459 bits (1181), Expect = e-129
 Identities = 233/595 (39%), Positives = 345/595 (57%), Gaps = 10/595 (1%)

Query: 17  CLLSLGGAIEIPMDLTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFF 76
           CLL     I+IP +L +PP IT+QS +  +V P D+I ++CEA G P   F WTR+   F
Sbjct: 17  CLL-----IQIPEELMEPPVITEQSPRRLVVFPTDDISLKCEASGKPEVQFRWTRDGVHF 71

Query: 77  NIAKDPRVSMRR--RSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSP 134
              ++  V++ +   SG+  I   +    + ++G Y+CFA NK GTA+S+ IRL    +P
Sbjct: 72  KPKEELGVTVYQSPHSGSFTITGNNSNFAQRFQGIYRCFASNKLGTAMSHEIRLMAEGAP 131

Query: 135 LWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFS 194
            WPKE + PV V+EG  + L CNPPP      I+WM+S +  I QD+RV+ G NG+LYF+
Sbjct: 132 KWPKETVKPVEVEEGESVVLPCNPPPSAEPLRIYWMNSKILHIKQDERVTMGQNGNLYFA 191

Query: 195 NVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLR 254
           NV+  D  +DY C+A F  T TI QK P  L+V  T  + +R P  ++P  ++S  + L+
Sbjct: 192 NVLTSDNHSDYICHAHFPGTRTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSSHLVALQ 251

Query: 255 GMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASN 314
           G  L+LECIA G PTP I W +  G +P+D+  ++N NK L++  V EED GEY CLA N
Sbjct: 252 GQPLVLECIAEGFPTPTIKWLRPSGPMPADRVTYQNHNKTLQLLKVGEEDDGEYRCLAEN 311

Query: 315 KMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSA 374
            +GS RH   V V+AAPYWL +P++ +  PGE  RL C+  G P+P V W +NG P++  
Sbjct: 312 SLGSARHAYYVTVEAAPYWLHKPQSHLYGPGETARLDCQVQGRPQPEVTWRINGIPVEEL 371

Query: 375 PPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLI 434
             +    +    +I  + Q S   V QC   N HG LLANA++ V+ +P ++L+  NQ  
Sbjct: 372 AKDQKYRIQRGALILSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQLPAKILTADNQTY 431

Query: 435 RVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYT 494
             +  +   L C  FG+P+P+++W      + L    +  Y NG+L I+ ++  D G Y 
Sbjct: 432 MAVQGSTAYLLCKAFGAPVPSVQWLDEDGTTVLQDERFFPYANGTLGIRDLQANDTGRYF 491

Query: 495 CVATNILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKD 554
           C+A N          L+VKD T+I + P   + ++G+ V   C+   DPSL+ +++W  D
Sbjct: 492 CLAANDQNNVTIMANLKVKDATQITQGPRSTIEKKGSRVTFTCQASFDPSLQPSITWRGD 551

Query: 555 DEPLY-IGNRMKK--EDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTVLGN 606
              L  +G+  K   ED  L I  +   DQG+Y+CVASTELD   ++A L V+G+
Sbjct: 552 GRDLQELGDSDKYFIEDGRLVIHSLDYSDQGNYSCVASTELDVVESRAQLLVVGS 606



 Score = 67.0 bits (162), Expect = 5e-11
 Identities = 72/295 (24%), Positives = 119/295 (40%), Gaps = 28/295 (9%)

Query: 43  KDHIVDPRDNILIECEAKGNPAPSFHWTRNS-RFFNIAKDPRVSMRRRSGTLVIDFRSGG 101
           + H+  P +   ++C+ +G P P   W  N      +AKD +  ++R  G L++   S  
Sbjct: 335 QSHLYGPGETARLDCQVQGRPQPEVTWRINGIPVEELAKDQKYRIQR--GALIL---SNV 389

Query: 102 RPEEYEGEYQCFARNKFGTALSNRIRLQVS-KSPLWPKENLDPVVVQEGAPLTLQCNPPP 160
           +P +     QC ARN+ G  L+N     V   + +   +N   + VQ G+   L C    
Sbjct: 390 QPSDTMVT-QCEARNRHGLLLANAYIYVVQLPAKILTADNQTYMAVQ-GSTAYLLCKAF- 446

Query: 161 GLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQK 220
           G P P + W+      + QD+R     NG L   ++   D         R+       Q 
Sbjct: 447 GAPVPSVQWLDEDGTTVLQDERFFPYANGTLGIRDLQAND-------TGRYFCLAANDQN 499

Query: 221 NPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPT--PDIAWYKKG 278
           N   + ++    V + T     P+ T       +G  +   C AS  P+  P I W   G
Sbjct: 500 N---VTIMANLKVKDATQITQGPRSTIEK----KGSRVTFTCQASFDPSLQPSITWRGDG 552

Query: 279 GDLPS--DKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAP 331
            DL    D  K+   +  L I ++   D G Y C+AS ++  +     + V  +P
Sbjct: 553 RDLQELGDSDKYFIEDGRLVIHSLDYSDQGNYSCVASTELDVVESRAQLLVVGSP 607


>gi|13435353 L1 cell adhesion molecule isoform 2 precursor [Homo
           sapiens]
          Length = 1253

 Score =  452 bits (1162), Expect = e-127
 Identities = 232/600 (38%), Positives = 345/600 (57%), Gaps = 15/600 (2%)

Query: 17  CLLSLGGAIEIPMD-----LTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTR 71
           CLL     I+IP +     + +PP IT+QS +  +V P D+I ++CEA G P   F WTR
Sbjct: 17  CLL-----IQIPEEYEGHHVMEPPVITEQSPRRLVVFPTDDISLKCEASGKPEVQFRWTR 71

Query: 72  NSRFFNIAKDPRVSMRR--RSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQ 129
           +   F   ++  V++ +   SG+  I   +    + ++G Y+CFA NK GTA+S+ IRL 
Sbjct: 72  DGVHFKPKEELGVTVYQSPHSGSFTITGNNSNFAQRFQGIYRCFASNKLGTAMSHEIRLM 131

Query: 130 VSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNG 189
              +P WPKE + PV V+EG  + L CNPPP      I+WM+S +  I QD+RV+ G NG
Sbjct: 132 AEGAPKWPKETVKPVEVEEGESVVLPCNPPPSAEPLRIYWMNSKILHIKQDERVTMGQNG 191

Query: 190 DLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASS 249
           +LYF+NV+  D  +DY C+A F  T TI QK P  L+V  T  + +R P  ++P  ++S 
Sbjct: 192 NLYFANVLTSDNHSDYICHAHFPGTRTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSSH 251

Query: 250 QMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYF 309
            + L+G  L+LECIA G PTP I W +  G +P+D+  ++N NK L++  V EED GEY 
Sbjct: 252 LVALQGQPLVLECIAEGFPTPTIKWLRPSGPMPADRVTYQNHNKTLQLLKVGEEDDGEYR 311

Query: 310 CLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGE 369
           CLA N +GS RH   V V+AAPYWL +P++ +  PGE  RL C+  G P+P V W +NG 
Sbjct: 312 CLAENSLGSARHAYYVTVEAAPYWLHKPQSHLYGPGETARLDCQVQGRPQPEVTWRINGI 371

Query: 370 PLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSP 429
           P++    +    +    +I  + Q S   V QC   N HG LLANA++ V+ +P ++L+ 
Sbjct: 372 PVEELAKDQKYRIQRGALILSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQLPAKILTA 431

Query: 430 RNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKED 489
            NQ    +  +   L C  FG+P+P+++W      + L    +  Y NG+L I+ ++  D
Sbjct: 432 DNQTYMAVQGSTAYLLCKAFGAPVPSVQWLDEDGTTVLQDERFFPYANGTLGIRDLQAND 491

Query: 490 QGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTV 549
            G Y C+A N          L+VKD T+I + P   + ++G+ V   C+   DPSL+ ++
Sbjct: 492 TGRYFCLAANDQNNVTIMANLKVKDATQITQGPRSTIEKKGSRVTFTCQASFDPSLQPSI 551

Query: 550 SWLKDDEPLY-IGNRMKK--EDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTVLGN 606
           +W  D   L  +G+  K   ED  L I  +   DQG+Y+CVASTELD   ++A L V+G+
Sbjct: 552 TWRGDGRDLQELGDSDKYFIEDGRLVIHSLDYSDQGNYSCVASTELDVVESRAQLLVVGS 611



 Score = 67.0 bits (162), Expect = 5e-11
 Identities = 72/295 (24%), Positives = 119/295 (40%), Gaps = 28/295 (9%)

Query: 43  KDHIVDPRDNILIECEAKGNPAPSFHWTRNS-RFFNIAKDPRVSMRRRSGTLVIDFRSGG 101
           + H+  P +   ++C+ +G P P   W  N      +AKD +  ++R  G L++   S  
Sbjct: 340 QSHLYGPGETARLDCQVQGRPQPEVTWRINGIPVEELAKDQKYRIQR--GALIL---SNV 394

Query: 102 RPEEYEGEYQCFARNKFGTALSNRIRLQVS-KSPLWPKENLDPVVVQEGAPLTLQCNPPP 160
           +P +     QC ARN+ G  L+N     V   + +   +N   + VQ G+   L C    
Sbjct: 395 QPSDTMVT-QCEARNRHGLLLANAYIYVVQLPAKILTADNQTYMAVQ-GSTAYLLCKAF- 451

Query: 161 GLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQK 220
           G P P + W+      + QD+R     NG L   ++   D         R+       Q 
Sbjct: 452 GAPVPSVQWLDEDGTTVLQDERFFPYANGTLGIRDLQAND-------TGRYFCLAANDQN 504

Query: 221 NPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPT--PDIAWYKKG 278
           N   + ++    V + T     P+ T       +G  +   C AS  P+  P I W   G
Sbjct: 505 N---VTIMANLKVKDATQITQGPRSTIEK----KGSRVTFTCQASFDPSLQPSITWRGDG 557

Query: 279 GDLPS--DKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAP 331
            DL    D  K+   +  L I ++   D G Y C+AS ++  +     + V  +P
Sbjct: 558 RDLQELGDSDKYFIEDGRLVIHSLDYSDQGNYSCVASTELDVVESRAQLLVVGSP 612


>gi|4557707 L1 cell adhesion molecule isoform 1 precursor [Homo
           sapiens]
          Length = 1257

 Score =  452 bits (1162), Expect = e-127
 Identities = 232/600 (38%), Positives = 345/600 (57%), Gaps = 15/600 (2%)

Query: 17  CLLSLGGAIEIPMD-----LTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTR 71
           CLL     I+IP +     + +PP IT+QS +  +V P D+I ++CEA G P   F WTR
Sbjct: 17  CLL-----IQIPEEYEGHHVMEPPVITEQSPRRLVVFPTDDISLKCEASGKPEVQFRWTR 71

Query: 72  NSRFFNIAKDPRVSMRR--RSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQ 129
           +   F   ++  V++ +   SG+  I   +    + ++G Y+CFA NK GTA+S+ IRL 
Sbjct: 72  DGVHFKPKEELGVTVYQSPHSGSFTITGNNSNFAQRFQGIYRCFASNKLGTAMSHEIRLM 131

Query: 130 VSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNG 189
              +P WPKE + PV V+EG  + L CNPPP      I+WM+S +  I QD+RV+ G NG
Sbjct: 132 AEGAPKWPKETVKPVEVEEGESVVLPCNPPPSAEPLRIYWMNSKILHIKQDERVTMGQNG 191

Query: 190 DLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASS 249
           +LYF+NV+  D  +DY C+A F  T TI QK P  L+V  T  + +R P  ++P  ++S 
Sbjct: 192 NLYFANVLTSDNHSDYICHAHFPGTRTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSSH 251

Query: 250 QMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYF 309
            + L+G  L+LECIA G PTP I W +  G +P+D+  ++N NK L++  V EED GEY 
Sbjct: 252 LVALQGQPLVLECIAEGFPTPTIKWLRPSGPMPADRVTYQNHNKTLQLLKVGEEDDGEYR 311

Query: 310 CLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGE 369
           CLA N +GS RH   V V+AAPYWL +P++ +  PGE  RL C+  G P+P V W +NG 
Sbjct: 312 CLAENSLGSARHAYYVTVEAAPYWLHKPQSHLYGPGETARLDCQVQGRPQPEVTWRINGI 371

Query: 370 PLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSP 429
           P++    +    +    +I  + Q S   V QC   N HG LLANA++ V+ +P ++L+ 
Sbjct: 372 PVEELAKDQKYRIQRGALILSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQLPAKILTA 431

Query: 430 RNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKED 489
            NQ    +  +   L C  FG+P+P+++W      + L    +  Y NG+L I+ ++  D
Sbjct: 432 DNQTYMAVQGSTAYLLCKAFGAPVPSVQWLDEDGTTVLQDERFFPYANGTLGIRDLQAND 491

Query: 490 QGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTV 549
            G Y C+A N          L+VKD T+I + P   + ++G+ V   C+   DPSL+ ++
Sbjct: 492 TGRYFCLAANDQNNVTIMANLKVKDATQITQGPRSTIEKKGSRVTFTCQASFDPSLQPSI 551

Query: 550 SWLKDDEPLY-IGNRMKK--EDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTVLGN 606
           +W  D   L  +G+  K   ED  L I  +   DQG+Y+CVASTELD   ++A L V+G+
Sbjct: 552 TWRGDGRDLQELGDSDKYFIEDGRLVIHSLDYSDQGNYSCVASTELDVVESRAQLLVVGS 611



 Score = 67.0 bits (162), Expect = 5e-11
 Identities = 72/295 (24%), Positives = 119/295 (40%), Gaps = 28/295 (9%)

Query: 43  KDHIVDPRDNILIECEAKGNPAPSFHWTRNS-RFFNIAKDPRVSMRRRSGTLVIDFRSGG 101
           + H+  P +   ++C+ +G P P   W  N      +AKD +  ++R  G L++   S  
Sbjct: 340 QSHLYGPGETARLDCQVQGRPQPEVTWRINGIPVEELAKDQKYRIQR--GALIL---SNV 394

Query: 102 RPEEYEGEYQCFARNKFGTALSNRIRLQVS-KSPLWPKENLDPVVVQEGAPLTLQCNPPP 160
           +P +     QC ARN+ G  L+N     V   + +   +N   + VQ G+   L C    
Sbjct: 395 QPSDTMVT-QCEARNRHGLLLANAYIYVVQLPAKILTADNQTYMAVQ-GSTAYLLCKAF- 451

Query: 161 GLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQK 220
           G P P + W+      + QD+R     NG L   ++   D         R+       Q 
Sbjct: 452 GAPVPSVQWLDEDGTTVLQDERFFPYANGTLGIRDLQAND-------TGRYFCLAANDQN 504

Query: 221 NPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPT--PDIAWYKKG 278
           N   + ++    V + T     P+ T       +G  +   C AS  P+  P I W   G
Sbjct: 505 N---VTIMANLKVKDATQITQGPRSTIEK----KGSRVTFTCQASFDPSLQPSITWRGDG 557

Query: 279 GDLPS--DKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAP 331
            DL    D  K+   +  L I ++   D G Y C+AS ++  +     + V  +P
Sbjct: 558 RDLQELGDSDKYFIEDGRLVIHSLDYSDQGNYSCVASTELDVVESRAQLLVVGSP 612


>gi|27894376 cell adhesion molecule with homology to L1CAM precursor
           [Homo sapiens]
          Length = 1224

 Score =  412 bits (1059), Expect = e-115
 Identities = 240/621 (38%), Positives = 330/621 (53%), Gaps = 41/621 (6%)

Query: 15  LLCLLSLGGAIEIPMDLTQPPTITKQSAKDHIVDPRDNIL-IECEAKGNPAPSFHWTRNS 73
           +  LL    AIEIP  + Q PTI KQS K  +  P D    IECEAKGNP P+F WT++ 
Sbjct: 15  MFLLLKFSKAIEIPSSVQQVPTIIKQS-KVQVAFPFDEYFQIECEAKGNPEPTFSWTKDG 73

Query: 74  RFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKS 133
             F    D R+     SGT  I   + G    ++G+Y+CFA NK G A+S  I   V   
Sbjct: 74  NPFYFT-DHRIIPSNNSGTFRIP--NEGHISHFQGKYRCFASNKLGIAMSEEIEFIVPSV 130

Query: 134 PLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYF 193
           P +PKE +DP+ V+EG P+ L CNPP GLP   I+WM+  +E I QD+RV     GDLYF
Sbjct: 131 PKFPKEKIDPLEVEEGDPIVLPCNPPKGLPPLHIYWMNIELEHIEQDERVYMSQKGDLYF 190

Query: 194 SNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTR----------------GVAERT 237
           +NV  +D + DY C A F    TI QK P  L V + +                 + +R 
Sbjct: 191 ANVEEKDSRNDYCCFAAFPRLRTIVQKMPMKLTVNSLKHANDSSSSTEIGSKANSIKQRK 250

Query: 238 PSFMYP---QGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKA 294
           P  + P    G+ SS  +L+G  LLLEC A G+PTP + W K GGDLP  +   EN+ K 
Sbjct: 251 PKLLLPPTESGSESSITILKGEILLLECFAEGLPTPQVDWNKIGGDLPKGRETKENYGKT 310

Query: 295 LRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRA 354
           L+I NVS +D G Y C ASN +G+  H   V V+  P W  +P++ + + G +G L+C A
Sbjct: 311 LKIENVSYQDKGNYRCTASNFLGTATHDFHVIVEEPPRWTKKPQSAVYSTGSNGILLCEA 370

Query: 355 NGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTII-----FRDTQISSRAVYQCNTSNEHG 409
            G P+PT++W VNG P+ + P       AGD +      F + Q +  AVYQC  SN HG
Sbjct: 371 EGEPQPTIKWRVNGSPVDNHP------FAGDVVFPREISFTNLQPNHTAVYQCEASNVHG 424

Query: 410 YLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDG 469
            +LANA + V+DV P + +   +    ++     L C FF SP   + W K  +   L+G
Sbjct: 425 TILANANIDVVDVRPLIQTKDGENYATVVGYSAFLHCEFFASPEAVVSWQKVEEVKPLEG 484

Query: 470 GNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVARR 529
             YH+YENG+L+I    +ED G Y+C   N +GK      L++++ T++   P++    +
Sbjct: 485 RRYHIYENGTLQINRTTEEDAGSYSCWVENAIGKTAVTANLDIRNATKLRVSPKNPRIPK 544

Query: 530 GTTVQLECRVKHDPSLK--LTVSWLKDDEPLYIG----NRMKKEDDSLTIFGVAERDQGS 583
              ++L C  K D  LK  L +SW KD E   I      R+  +  +LTI  V   DQG 
Sbjct: 545 LHMLELHCESKCDSHLKHSLKLSWSKDGEAFEINGTEDGRIIIDGANLTISNVTLEDQGI 604

Query: 584 YTCVASTELDQDLAKAYLTVL 604
           Y C A T LD       +TVL
Sbjct: 605 YCCSAHTALDSAADITQVTVL 625



 Score = 82.0 bits (201), Expect = 1e-15
 Identities = 128/582 (21%), Positives = 209/582 (35%), Gaps = 93/582 (15%)

Query: 19  LSLGGAIEIPMDLTQPPTITKQSAKDHIVDPRDNILIECEA-KGNPAPSFHWTRNSRFFN 77
           L +  + EI   +   P   K+      V+  D I++ C   KG P    +W  N    +
Sbjct: 115 LGIAMSEEIEFIVPSVPKFPKEKIDPLEVEEGDPIVLPCNPPKGLPPLHIYWM-NIELEH 173

Query: 78  IAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFAR---------------------- 115
           I +D RV M ++      +       ++   +Y CFA                       
Sbjct: 174 IEQDERVYMSQKGDLYFANVEE----KDSRNDYCCFAAFPRLRTIVQKMPMKLTVNSLKH 229

Query: 116 -------NKFGTALSNRIRLQVSKSPLWPKEN--LDPVVVQEGAPLTLQCNPPPGLPSPV 166
                   + G+  +N I+ +  K  L P E+     + + +G  L L+C    GLP+P 
Sbjct: 230 ANDSSSSTEIGSK-ANSIKQRKPKLLLPPTESGSESSITILKGEILLLECFAE-GLPTPQ 287

Query: 167 IFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNAR------FHFTHTIQQK 220
           + W     + + + +   + +   L   NV  QD + +Y C A        H  H I ++
Sbjct: 288 VDWNKIGGD-LPKGRETKENYGKTLKIENVSYQD-KGNYRCTASNFLGTATHDFHVIVEE 345

Query: 221 NPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGD 280
            P   K                PQ    S     G + +L C A G P P I W   G  
Sbjct: 346 PPRWTKK---------------PQSAVYST----GSNGILLCEAEGEPQPTIKWRVNGS- 385

Query: 281 LPSDKAKFEN---FNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLD-- 335
            P D   F     F + +  TN+    +  Y C ASN  G+I    ++ V      +   
Sbjct: 386 -PVDNHPFAGDVVFPREISFTNLQPNHTAVYQCEASNVHGTILANANIDVVDVRPLIQTK 444

Query: 336 EPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREV---AGDTIIFRDT 392
           + +N     G    L C    +P+  V W    + ++   P   R        T+    T
Sbjct: 445 DGENYATVVGYSAFLHCEFFASPEAVVSW----QKVEEVKPLEGRRYHIYENGTLQINRT 500

Query: 393 QISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVI----LYNRTRLDCPF 448
                  Y C   N  G     A + + +     +SP+N  I  +    L+  ++ D   
Sbjct: 501 TEEDAGSYSCWVENAIGKTAVTANLDIRNATKLRVSPKNPRIPKLHMLELHCESKCDSHL 560

Query: 449 FGSPIPTLRWFKNGQGSNLDG--GNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAEN 506
             S    L W K+G+   ++G      + +  +L I  +  EDQGIY C A   L  A +
Sbjct: 561 KHSL--KLSWSKDGEAFEINGTEDGRIIIDGANLTISNVTLEDQGIYCCSAHTALDSAAD 618

Query: 507 QVR---LEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSL 545
             +   L+V DP     + E Q   R   +  E    H+ ++
Sbjct: 619 ITQVTVLDVPDPPENLHLSERQ--NRSVRLTWEAGADHNSNI 658


>gi|28373129 contactin 5 isoform short [Homo sapiens]
          Length = 1026

 Score =  245 bits (626), Expect = 8e-65
 Identities = 179/617 (29%), Positives = 270/617 (43%), Gaps = 46/617 (7%)

Query: 9   WVHAAFLLCLLSLGGAIEIPMDLTQPPTITKQSAKDHIVDPRDN----ILIECEAKGNPA 64
           W    FL   + L  +++      Q P        D I+ P D+    + + CE +GNP 
Sbjct: 5   WKLMLFLSVTMCLSESVDYGPVFVQEP--------DDIIFPTDSDEKKVALNCEVRGNPV 56

Query: 65  PSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSN 124
           PS+ W RN    ++  D R S+    GT +I   S  +     G YQC A N  G+ LS 
Sbjct: 57  PSYRWLRNGTEIDLESDYRYSLI--DGTFIISNPSEAKDS---GHYQCLATNTVGSILSR 111

Query: 125 RIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEP-ITQDKR- 182
              LQ +    +       V V+EG  + L C+PPP  P  +  W+ +     + +D R 
Sbjct: 112 EATLQFAYLGNFSGRTRSAVSVREGQGVVLMCSPPPHSPEIIYSWVFNEFPSFVAEDSRR 171

Query: 183 -VSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHT--IQQKNPFTLKVLTTRGVAERTPS 239
            +SQ   G+LY S V   D+ + Y C  +   T+   +    P TL+     G  E    
Sbjct: 172 FISQ-ETGNLYISKVQTSDVGS-YICLVKNTVTNARVLSPPTPLTLRNDGVMGEYEPKIE 229

Query: 240 FMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRITN 299
             +P    ++    +G  + +EC A G P P I W K  G +PS KA+       L I N
Sbjct: 230 VHFPFTVTAA----KGTTVKMECFALGNPVPTITWMKVNGYIPS-KARLRKSQAVLEIPN 284

Query: 300 VSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRANGNPK 359
           V  +D+G Y C A N  G       ++V   P+W+++  +  L  G   R  C+A G P+
Sbjct: 285 VQLDDAGIYECRAENSRGKNSFRGQLQVYTYPHWVEKLNDTQLDSGSPLRWECKATGKPR 344

Query: 360 PTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSV 419
           PT +W+ NG PL    P    E+    ++  +   S   +YQC   N++G + A+A + +
Sbjct: 345 PTYRWLKNGVPLS---PQSRVEMVNGVLMIHNVNQSDAGMYQCLAENKYGAIYASAELKI 401

Query: 420 LDVPPRMLSPRNQLIRVILYNRTR---LDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYE 476
           L   P      NQL + I+  + +   ++C   GSP PT+ W K G  +  +     +  
Sbjct: 402 LASAPTFAL--NQLKKTIIVTKDQEVVIECKPQGSPKPTISW-KKGDRAVRENKRIAILP 458

Query: 477 NGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTVQLE 536
           +GSL I    K D+G Y C   N+ G AE    L VK+PTRI   P+      G ++ L 
Sbjct: 459 DGSLRILNASKSDEGKYVCRGENVFGSAEIIASLSVKEPTRIELTPKRTELTVGESIVLN 518

Query: 537 CRVKHDPSLKLTVSWLKDDEPL--------YIGNRMKKEDDSLTIFGVAERDQGSYTCVA 588
           C+  HD SL +T  W    +P+        +   R +     L I  +     G Y C  
Sbjct: 519 CKAIHDASLDVTFYWTLKGQPIDFEEEGGHFESIRAQASSADLMIRNILLMHAGRYGCRV 578

Query: 589 STELDQDLAKAYLTVLG 605
            T  D    +A L V G
Sbjct: 579 QTTADSVSDEAELLVRG 595



 Score = 88.6 bits (218), Expect = 2e-17
 Identities = 97/374 (25%), Positives = 154/374 (41%), Gaps = 39/374 (10%)

Query: 260 LECIASGVPTPDIAWYKKGG--DLPSDKAKFENFNKALRITNVSE-EDSGEYFCLASNKM 316
           L C   G P P   W + G   DL SD  ++   +    I+N SE +DSG Y CLA+N +
Sbjct: 47  LNCEVRGNPVPSYRWLRNGTEIDLESDY-RYSLIDGTFIISNPSEAKDSGHYQCLATNTV 105

Query: 317 GSI-RHTISVRVKAAPYWLDEPKNLI-LAPGEDGRLVCRANGN-PKPTVQWMVNGEPLQS 373
           GSI     +++      +    ++ + +  G+   L+C    + P+    W+ N  P   
Sbjct: 106 GSILSREATLQFAYLGNFSGRTRSAVSVREGQGVVLMCSPPPHSPEIIYSWVFNEFPSFV 165

Query: 374 APPNPNREVAGDT--IIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRN 431
           A  +  R ++ +T  +     Q S    Y C   N     + NA V     PP  L+ RN
Sbjct: 166 AEDS-RRFISQETGNLYISKVQTSDVGSYICLVKNT----VTNARVLS---PPTPLTLRN 217

Query: 432 Q----------------LIRVILYNRTRLDCPFFGSPIPTLRWFK-NGQGSNLDGGNYHV 474
                             +        +++C   G+P+PT+ W K NG    +       
Sbjct: 218 DGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFALGNPVPTITWMKVNGY---IPSKARLR 274

Query: 475 YENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTVQ 534
                LEI  ++ +D GIY C A N  GK   + +L+V           D     G+ ++
Sbjct: 275 KSQAVLEIPNVQLDDAGIYECRAENSRGKNSFRGQLQVYTYPHWVEKLNDTQLDSGSPLR 334

Query: 535 LECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAERDQGSYTCVASTELDQ 594
            EC+    P  + T  WLK+  PL   +R++  +  L I  V + D G Y C+A  +   
Sbjct: 335 WECKATGKP--RPTYRWLKNGVPLSPQSRVEMVNGVLMIHNVNQSDAGMYQCLAENKYGA 392

Query: 595 DLAKAYLTVLGNCP 608
             A A L +L + P
Sbjct: 393 IYASAELKILASAP 406


>gi|7657359 contactin 5 isoform long [Homo sapiens]
          Length = 1100

 Score =  244 bits (623), Expect = 2e-64
 Identities = 173/582 (29%), Positives = 260/582 (44%), Gaps = 38/582 (6%)

Query: 44  DHIVDPRDN----ILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRS 99
           D I+ P D+    + + CE +GNP PS+ W RN    ++  D R S+    GT +I   S
Sbjct: 106 DDIIFPTDSDEKKVALNCEVRGNPVPSYRWLRNGTEIDLESDYRYSLI--DGTFIISNPS 163

Query: 100 GGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPP 159
             +     G YQC A N  G+ LS    LQ +    +       V V+EG  + L C+PP
Sbjct: 164 EAKDS---GHYQCLATNTVGSILSREATLQFAYLGNFSGRTRSAVSVREGQGVVLMCSPP 220

Query: 160 PGLPSPVIFWMSSSMEP-ITQDKR--VSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHT 216
           P  P  +  W+ +     + +D R  +SQ   G+LY S V   D+ + Y C  +   T+ 
Sbjct: 221 PHSPEIIYSWVFNEFPSFVAEDSRRFISQ-ETGNLYISKVQTSDVGS-YICLVKNTVTNA 278

Query: 217 --IQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAW 274
             +    P TL+     G  E      +P    ++    +G  + +EC A G P P I W
Sbjct: 279 RVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAA----KGTTVKMECFALGNPVPTITW 334

Query: 275 YKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWL 334
            K  G +PS KA+       L I NV  +D+G Y C A N  G       ++V   P+W+
Sbjct: 335 MKVNGYIPS-KARLRKSQAVLEIPNVQLDDAGIYECRAENSRGKNSFRGQLQVYTYPHWV 393

Query: 335 DEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQI 394
           ++  +  L  G   R  C+A G P+PT +W+ NG PL    P    E+    ++  +   
Sbjct: 394 EKLNDTQLDSGSPLRWECKATGKPRPTYRWLKNGVPLS---PQSRVEMVNGVLMIHNVNQ 450

Query: 395 SSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTR---LDCPFFGS 451
           S   +YQC   N++G + A+A + +L   P      NQL + I+  + +   ++C   GS
Sbjct: 451 SDAGMYQCLAENKYGAIYASAELKILASAPTFAL--NQLKKTIIVTKDQEVVIECKPQGS 508

Query: 452 PIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLE 511
           P PT+ W K G  +  +     +  +GSL I    K D+G Y C   N+ G AE    L 
Sbjct: 509 PKPTISW-KKGDRAVRENKRIAILPDGSLRILNASKSDEGKYVCRGENVFGSAEIIASLS 567

Query: 512 VKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPL--------YIGNR 563
           VK+PTRI   P+      G ++ L C+  HD SL +T  W    +P+        +   R
Sbjct: 568 VKEPTRIELTPKRTELTVGESIVLNCKAIHDASLDVTFYWTLKGQPIDFEEEGGHFESIR 627

Query: 564 MKKEDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTVLG 605
            +     L I  +     G Y C   T  D    +A L V G
Sbjct: 628 AQASSADLMIRNILLMHAGRYGCRVQTTADSVSDEAELLVRG 669



 Score = 88.6 bits (218), Expect = 2e-17
 Identities = 97/374 (25%), Positives = 154/374 (41%), Gaps = 39/374 (10%)

Query: 260 LECIASGVPTPDIAWYKKGG--DLPSDKAKFENFNKALRITNVSE-EDSGEYFCLASNKM 316
           L C   G P P   W + G   DL SD  ++   +    I+N SE +DSG Y CLA+N +
Sbjct: 121 LNCEVRGNPVPSYRWLRNGTEIDLESDY-RYSLIDGTFIISNPSEAKDSGHYQCLATNTV 179

Query: 317 GSI-RHTISVRVKAAPYWLDEPKNLI-LAPGEDGRLVCRANGN-PKPTVQWMVNGEPLQS 373
           GSI     +++      +    ++ + +  G+   L+C    + P+    W+ N  P   
Sbjct: 180 GSILSREATLQFAYLGNFSGRTRSAVSVREGQGVVLMCSPPPHSPEIIYSWVFNEFPSFV 239

Query: 374 APPNPNREVAGDT--IIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRN 431
           A  +  R ++ +T  +     Q S    Y C   N     + NA V     PP  L+ RN
Sbjct: 240 AEDS-RRFISQETGNLYISKVQTSDVGSYICLVKNT----VTNARVLS---PPTPLTLRN 291

Query: 432 Q----------------LIRVILYNRTRLDCPFFGSPIPTLRWFK-NGQGSNLDGGNYHV 474
                             +        +++C   G+P+PT+ W K NG    +       
Sbjct: 292 DGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFALGNPVPTITWMKVNGY---IPSKARLR 348

Query: 475 YENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTVQ 534
                LEI  ++ +D GIY C A N  GK   + +L+V           D     G+ ++
Sbjct: 349 KSQAVLEIPNVQLDDAGIYECRAENSRGKNSFRGQLQVYTYPHWVEKLNDTQLDSGSPLR 408

Query: 535 LECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAERDQGSYTCVASTELDQ 594
            EC+    P  + T  WLK+  PL   +R++  +  L I  V + D G Y C+A  +   
Sbjct: 409 WECKATGKP--RPTYRWLKNGVPLSPQSRVEMVNGVLMIHNVNQSDAGMYQCLAENKYGA 466

Query: 595 DLAKAYLTVLGNCP 608
             A A L +L + P
Sbjct: 467 IYASAELKILASAP 480



 Score = 66.2 bits (160), Expect = 8e-11
 Identities = 65/304 (21%), Positives = 122/304 (40%), Gaps = 38/304 (12%)

Query: 40  QSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRS 99
           +   D  +D    +  EC+A G P P++ W +N     +   P+  +   +G L+I    
Sbjct: 394 EKLNDTQLDSGSPLRWECKATGKPRPTYRWLKN----GVPLSPQSRVEMVNGVLMIH--- 446

Query: 100 GGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENL-DPVVVQEGAPLTLQCNP 158
               +   G YQC A NK+G   ++     ++ +P +    L   ++V +   + ++C  
Sbjct: 447 -NVNQSDAGMYQCLAENKYGAIYASAELKILASAPTFALNQLKKTIIVTKDQEVVIECK- 504

Query: 159 PPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQ 218
           P G P P I W       + ++KR++   +G L   N    D +  Y C     F     
Sbjct: 505 PQGSPKPTISWKKGD-RAVRENKRIAILPDGSLRILNASKSD-EGKYVCRGENVFG---- 558

Query: 219 QKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWY--- 275
                + +++ +  V E T   + P+ T     +  G  ++L C A    + D+ +Y   
Sbjct: 559 -----SAEIIASLSVKEPTRIELTPKRTE----LTVGESIVLNCKAIHDASLDVTFYWTL 609

Query: 276 --------KKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRV 327
                   ++GG   S +A+  + +  L I N+    +G Y C       S+     + V
Sbjct: 610 KGQPIDFEEEGGHFESIRAQASSAD--LMIRNILLMHAGRYGCRVQTTADSVSDEAELLV 667

Query: 328 KAAP 331
           +  P
Sbjct: 668 RGPP 671



 Score = 43.9 bits (102), Expect = 4e-04
 Identities = 38/178 (21%), Positives = 76/178 (42%), Gaps = 21/178 (11%)

Query: 31  LTQPPTITKQSAKDHIVDPRDN-ILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRR 89
           L   PT      K  I+  +D  ++IEC+ +G+P P+  W +  R   + ++ R+++   
Sbjct: 476 LASAPTFALNQLKKTIIVTKDQEVVIECKPQGSPKPTISWKKGDR--AVRENKRIAILPD 533

Query: 90  SGTLVIDFRSGGRPEEYEGEYQCFARNKFGTA--LSNRIRLQVSKSPLWPKENLDPVVVQ 147
               +++       +  EG+Y C   N FG+A  +++    + ++  L PK       + 
Sbjct: 534 GSLRILN-----ASKSDEGKYVCRGENVFGSAEIIASLSVKEPTRIELTPKR----TELT 584

Query: 148 EGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKR-------VSQGHNGDLYFSNVML 198
            G  + L C         V F+ +   +PI  ++         +Q  + DL   N++L
Sbjct: 585 VGESIVLNCKAIHDASLDVTFYWTLKGQPIDFEEEGGHFESIRAQASSADLMIRNILL 642


>gi|28373122 contactin 4 isoform a precursor [Homo sapiens]
          Length = 1026

 Score =  234 bits (598), Expect = 1e-61
 Identities = 176/614 (28%), Positives = 270/614 (43%), Gaps = 38/614 (6%)

Query: 8   PW---VHAAFLLCLLSLGGAIEIPMDLTQPPTITKQSAKDHIVDPRDNILIECEAKGNPA 64
           PW   V  +F+LCL      +  P+ + +P  +      +        + + CE KGNP 
Sbjct: 4   PWELLVLQSFILCLAD-DSTLHGPIFIQEPSPVMFPLDSEE-----KKVKLNCEVKGNPK 57

Query: 65  PSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSN 124
           P   W  N    +   D R S+    G+L+I+        +  G YQC A N FGT +S 
Sbjct: 58  PHIRWKLNGTDVDTGMDFRYSVVE--GSLLIN---NPNKTQDAGTYQCTATNSFGTIVSR 112

Query: 125 RIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVS 184
             +LQ +    +       V V+ G  + L C PPP        W+ +       ++R  
Sbjct: 113 EAKLQFAYLDNFKTRTRSTVSVRRGQGMVLLCGPPPHSGELSYAWIFNEYPSYQDNRRFV 172

Query: 185 QGHNGDLYFSNVMLQDMQTDYSCNARFHFTH--TIQQKNPFTLKVLTTRGVAERTPSFMY 242
               G+LY + V   D+  +Y+C      T+   +    P  L+     G  E      +
Sbjct: 173 SQETGNLYIAKVEKSDVG-NYTCVVTNTVTNHKVLGPPTPLILRNDGVMGEYEPKIEVQF 231

Query: 243 PQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSE 302
           P+   ++    +G  + LEC A G P P I W +  G   + KA+    N  L I N  +
Sbjct: 232 PETVPTA----KGATVKLECFALGNPVPTIIWRRADGKPIARKARRHKSNGILEIPNFQQ 287

Query: 303 EDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTV 362
           ED+G Y C+A N  G       +   A P W+ +  ++ +A  E+    C+ANG PKPT 
Sbjct: 288 EDAGLYECVAENSRGKNVARGQLTFYAQPNWIQKINDIHVAMEENVFWECKANGRPKPTY 347

Query: 363 QWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDV 422
           +W+ NGEPL +       ++   T+      +S   +YQC   N+HG + +NA +SV+ V
Sbjct: 348 KWLKNGEPLLT---RDRIQIEQGTLNITIVNLSDAGMYQCLAENKHGVIFSNAELSVIAV 404

Query: 423 PP---RMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGS 479
            P   R L  R  L++V       ++C    SP P   W K G+    +     + E+G+
Sbjct: 405 GPDFSRTLLKRVTLVKV--GGEVVIECKPKASPKPVYTW-KKGRDILKENERITISEDGN 461

Query: 480 LEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTVQLECRV 539
           L I  + K D G YTC+ATN  G A +   L VKDPTR+   P       G ++ L C+V
Sbjct: 462 LRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKDPTRVMVPPSSMDVTVGESIVLPCQV 521

Query: 540 KHDPSLKLTVSW------LKDDEPLYIGNRMKKEDDS--LTIFGVAERDQGSYTCVASTE 591
            HD SL +  +W      +  D       R+  +D +  L I  +  +  G Y C+  T 
Sbjct: 522 THDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQDSAGDLMIRNIQLKHAGKYVCMVQTS 581

Query: 592 LDQDLAKAYLTVLG 605
           +D+  A A L V G
Sbjct: 582 VDRLSAAADLIVRG 595



 Score = 88.6 bits (218), Expect = 2e-17
 Identities = 101/373 (27%), Positives = 156/373 (41%), Gaps = 38/373 (10%)

Query: 260 LECIASGVPTPDIAWYKKGGDLPSDKA-KFENFNKALRITNVSE-EDSGEYFCLASNKMG 317
           L C   G P P I W   G D+ +    ++     +L I N ++ +D+G Y C A+N  G
Sbjct: 48  LNCEVKGNPKPHIRWKLNGTDVDTGMDFRYSVVEGSLLINNPNKTQDAGTYQCTATNSFG 107

Query: 318 SIRHTISVRVKAAPYWLDEPKN-----LILAPGEDGRLVCRANGNPKP-----TVQWMVN 367
           +I   +S   K    +LD  K      + +  G+   L+C     P P     +  W+ N
Sbjct: 108 TI---VSREAKLQFAYLDNFKTRTRSTVSVRRGQGMVLLC----GPPPHSGELSYAWIFN 160

Query: 368 GEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQC---NTSNEHGYL-------LANAFV 417
             P          +  G+  I +  + S    Y C   NT   H  L       L N  V
Sbjct: 161 EYPSYQDNRRFVSQETGNLYIAK-VEKSDVGNYTCVVTNTVTNHKVLGPPTPLILRNDGV 219

Query: 418 SVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYEN 477
            + +  P++     + +        +L+C   G+P+PT+ W +   G  +         N
Sbjct: 220 -MGEYEPKIEVQFPETVPTAKGATVKLECFALGNPVPTIIW-RRADGKPIARKARRHKSN 277

Query: 478 GSLEIKMIRKEDQGIYTCVATNILGK--AENQVRLEVKDPTRIYRMPEDQVARRGTTVQL 535
           G LEI   ++ED G+Y CVA N  GK  A  Q+    + P  I ++ +  VA     V  
Sbjct: 278 GILEIPNFQQEDAGLYECVAENSRGKNVARGQLTFYAQ-PNWIQKINDIHVAME-ENVFW 335

Query: 536 ECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAERDQGSYTCVASTELDQD 595
           EC+    P  K T  WLK+ EPL   +R++ E  +L I  V   D G Y C+A  +    
Sbjct: 336 ECKANGRP--KPTYKWLKNGEPLLTRDRIQIEQGTLNITIVNLSDAGMYQCLAENKHGVI 393

Query: 596 LAKAYLTVLGNCP 608
            + A L+V+   P
Sbjct: 394 FSNAELSVIAVGP 406



 Score = 70.9 bits (172), Expect = 3e-12
 Identities = 74/307 (24%), Positives = 122/307 (39%), Gaps = 44/307 (14%)

Query: 40  QSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRS 99
           Q   D  V   +N+  EC+A G P P++ W +N     + +D R+ + + +  + I   S
Sbjct: 320 QKINDIHVAMEENVFWECKANGRPKPTYKWLKNGEPL-LTRD-RIQIEQGTLNITIVNLS 377

Query: 100 GGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPV-VVQEGAPLTLQCNP 158
                   G YQC A NK G   SN     ++  P + +  L  V +V+ G  + ++C P
Sbjct: 378 DA------GMYQCLAENKHGVIFSNAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKP 431

Query: 159 PPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQ 218
               P PV  W     + + +++R++   +G+L   NV   D  + Y+C A  HF     
Sbjct: 432 KAS-PKPVYTW-KKGRDILKENERITISEDGNLRIINVTKSDAGS-YTCIATNHF----- 483

Query: 219 QKNPFTLKVLTTRGVAERTPSFMYPQGTA-----SSQMVLRGMDLLLECIASGVPTPDIA 273
                        G A  T + +    T      SS  V  G  ++L C  +   + DI 
Sbjct: 484 -------------GTASSTGNLVVKDPTRVMVPPSSMDVTVGESIVLPCQVTHDHSLDIV 530

Query: 274 --WYKKGG--DLPSDKAKFENFNKA-----LRITNVSEEDSGEYFCLASNKMGSIRHTIS 324
             W   G   D   D   FE          L I N+  + +G+Y C+    +  +     
Sbjct: 531 FTWSFNGHLIDFDRDGDHFERVGGQDSAGDLMIRNIQLKHAGKYVCMVQTSVDRLSAAAD 590

Query: 325 VRVKAAP 331
           + V+  P
Sbjct: 591 LIVRGPP 597


>gi|75709184 contactin 3 [Homo sapiens]
          Length = 1028

 Score =  226 bits (577), Expect = 4e-59
 Identities = 172/618 (27%), Positives = 267/618 (43%), Gaps = 43/618 (6%)

Query: 8   PWVHAAFLLCLLSLGGAIEIPMDLTQPPTITKQSAKDHI-VDPRDN-ILIECEAKGNPAP 65
           PW     L  +  LGG +     L Q P   K+ +     V   D  I + CEA+GNP+P
Sbjct: 4   PWKQLILLSFIGCLGGEL-----LLQGPVFIKEPSNSIFPVGSEDKKITLHCEARGNPSP 58

Query: 66  SFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNR 125
            + W  N    +++ + R  +    G LV+            G YQCFA N  GT +S  
Sbjct: 59  HYRWQLNGSDIDMSMEHRYKLN--GGNLVV---INPNRNWDTGTYQCFATNSLGTIVSRE 113

Query: 126 IRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQD--KRV 183
            +LQ +    +  +    V V+EG  + L C PPP        W+ +      ++  +R 
Sbjct: 114 AKLQFAYLENFKTKMRSTVSVREGQGVVLLCGPPPHSGELSYAWIFNEYPSFVEEDSRRF 173

Query: 184 SQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHT--IQQKNPFTLKVLTTRGVAERTPSFM 241
                G LY S V   D+  +Y+C      T+   +    P  L+     G  E      
Sbjct: 174 VSQETGHLYISKVEPSDVG-NYTCVVTSMVTNARVLGSPTPLVLRSDGVMGEYEPKIEVQ 232

Query: 242 YPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVS 301
           +P+   ++    +G  + LEC A G P P I W +  G   S K K   F+  L I N  
Sbjct: 233 FPETLPAA----KGSTVKLECFALGNPIPQINWRRSDGLPFSSKIKLRKFSGVLEIPNFQ 288

Query: 302 EEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPT 361
           +ED+G Y C+A N  G       +   A P+W+   K++ +A  +     CRA+G PKP+
Sbjct: 289 QEDAGSYECIAENSRGKNVARGRLTYYAKPHWVQLIKDVEIAVEDSLYWECRASGKPKPS 348

Query: 362 VQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVL- 420
            +W+ NG  L         ++    +   +  ++   ++QC   N+HG + ++A + V+ 
Sbjct: 349 YRWLKNGAALVL---EERTQIENGALTISNLSVTDSGMFQCIAENKHGLVYSSAELKVVA 405

Query: 421 DVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSL 480
             P    +P  +L++V + +   LDC    SP     W K G  S  +     +  +G L
Sbjct: 406 SAPDFSKNPMKKLVQVQVGSLVSLDCKPRASPRALSSW-KKGDVSVQEHERISLLNDGGL 464

Query: 481 EIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVK 540
           +I  + K D G YTC+A N  GKA     L V +PTRI   P +     G +V L C+V+
Sbjct: 465 KIANVTKADAGTYTCMAENQFGKANGTTHLVVTEPTRITLAPSNMDVSVGESVILPCQVQ 524

Query: 541 HDPSLKLTVSW--------LKDDEPLYIGNRMKKEDDS----LTIFGVAERDQGSYTCVA 588
           HDP L +  +W         K D     G+  +K   S    L I  +  +  G Y C+ 
Sbjct: 525 HDPLLDIIFTWYFNGALADFKKD-----GSHFEKVGGSSSGDLMIRNIQLKHSGKYVCMV 579

Query: 589 STELDQDLAKAYLTVLGN 606
            T +D   + A L V G+
Sbjct: 580 QTGVDSVSSAADLIVRGS 597



 Score = 81.6 bits (200), Expect = 2e-15
 Identities = 81/301 (26%), Positives = 128/301 (42%), Gaps = 33/301 (10%)

Query: 40  QSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRS 99
           Q  KD  +   D++  EC A G P PS+ W +N     + +  ++     +G L I   S
Sbjct: 322 QLIKDVEIAVEDSLYWECRASGKPKPSYRWLKNGAALVLEERTQIE----NGALTISNLS 377

Query: 100 GGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVV-VQEGAPLTLQCNP 158
                   G +QC A NK G   S+     V+ +P + K  +  +V VQ G+ ++L C P
Sbjct: 378 ----VTDSGMFQCIAENKHGLVYSSAELKVVASAPDFSKNPMKKLVQVQVGSLVSLDCKP 433

Query: 159 PPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQ 218
               P  +  W    +  + + +R+S  ++G L  +NV   D  T Y+C A   F     
Sbjct: 434 RAS-PRALSSWKKGDVS-VQEHERISLLNDGGLKIANVTKADAGT-YTCMAENQFG---- 486

Query: 219 QKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDI--AWYK 276
           + N  T  V+T     E T   + P    S+  V  G  ++L C     P  DI   WY 
Sbjct: 487 KANGTTHLVVT-----EPTRITLAP----SNMDVSVGESVILPCQVQHDPLLDIIFTWYF 537

Query: 277 KGG--DLPSDKAKFENFNKA----LRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAA 330
            G   D   D + FE    +    L I N+  + SG+Y C+    + S+     + V+ +
Sbjct: 538 NGALADFKKDGSHFEKVGGSSSGDLMIRNIQLKHSGKYVCMVQTGVDSVSSAADLIVRGS 597

Query: 331 P 331
           P
Sbjct: 598 P 598



 Score = 79.0 bits (193), Expect = 1e-14
 Identities = 89/378 (23%), Positives = 154/378 (40%), Gaps = 42/378 (11%)

Query: 258 LLLECIASGVPTPDIAWYKKGGDLP-SDKAKFENFNKALRITNVSEE-DSGEYFCLASNK 315
           + L C A G P+P   W   G D+  S + +++     L + N +   D+G Y C A+N 
Sbjct: 46  ITLHCEARGNPSPHYRWQLNGSDIDMSMEHRYKLNGGNLVVINPNRNWDTGTYQCFATNS 105

Query: 316 MGSIRHTISVRVKAAPYWLDEPKNLI-----LAPGEDGRLVCRANGNPKP-----TVQWM 365
           +G+I   +S   K    +L+  K  +     +  G+   L+C     P P     +  W+
Sbjct: 106 LGTI---VSREAKLQFAYLENFKTKMRSTVSVREGQGVVLLC----GPPPHSGELSYAWI 158

Query: 366 VNGEPLQSAPPNPNREVAGDT--IIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVP 423
            N  P      +  R V+ +T  +     + S    Y C  ++    ++ NA V     P
Sbjct: 159 FNEYP-SFVEEDSRRFVSQETGHLYISKVEPSDVGNYTCVVTS----MVTNARVLGSPTP 213

Query: 424 -------------PRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGG 470
                        P++     + +     +  +L+C   G+PIP + W +   G      
Sbjct: 214 LVLRSDGVMGEYEPKIEVQFPETLPAAKGSTVKLECFALGNPIPQINW-RRSDGLPFSSK 272

Query: 471 NYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVARRG 530
                 +G LEI   ++ED G Y C+A N  GK   + RL         ++ +D      
Sbjct: 273 IKLRKFSGVLEIPNFQQEDAGSYECIAENSRGKNVARGRLTYYAKPHWVQLIKDVEIAVE 332

Query: 531 TTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAERDQGSYTCVAST 590
            ++  ECR    P  K +  WLK+   L +  R + E+ +LTI  ++  D G + C+A  
Sbjct: 333 DSLYWECRASGKP--KPSYRWLKNGAALVLEERTQIENGALTISNLSVTDSGMFQCIAEN 390

Query: 591 ELDQDLAKAYLTVLGNCP 608
           +     + A L V+ + P
Sbjct: 391 KHGLVYSSAELKVVASAP 408


>gi|4827022 contactin 2 precursor [Homo sapiens]
          Length = 1040

 Score =  226 bits (576), Expect = 5e-59
 Identities = 174/571 (30%), Positives = 251/571 (43%), Gaps = 35/571 (6%)

Query: 51  DNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEY 110
           + +L+ C A+ +P  ++ W  N     +  +P    +   G LVI         +  G Y
Sbjct: 55  EQVLLACRARASPPATYRWKMNGTEMKL--EPGSRHQLVGGNLVI---MNPTKAQDAGVY 109

Query: 111 QCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWM 170
           QC A N  GT +S    L+      + KE  DPV   EG  + L CNPP   P     W+
Sbjct: 110 QCLASNPVGTVVSREAILRFGFLQEFSKEERDPVKAHEGWGVMLPCNPPAHYPGLSYRWL 169

Query: 171 SSSMEPI--TQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQK-NPFTLKV 227
            +       T  +       G+LY +     D+  +YSC A  H   + +   + F    
Sbjct: 170 LNEFPNFIPTDGRHFVSQTTGNLYIARTNASDLG-NYSCLATSHMDFSTKSVFSKFAQLN 228

Query: 228 LTTRGVAERTPSFM--YPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDK 285
           L         PS    +P  T +    L G  + LEC A G P P I W K  G L    
Sbjct: 229 LAAEDTRLFAPSIKARFPAETYA----LVGQQVTLECFAFGNPVPRIKWRKVDGSL---S 281

Query: 286 AKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVR--VKAAPYWLDEPKNLILA 343
            ++      L+I +VS ED G Y C A N  G  R T+  R  V+A P WL    +    
Sbjct: 282 PQWTTAEPTLQIPSVSFEDEGTYECEAENSKG--RDTVQGRIIVQAQPEWLKVISDTEAD 339

Query: 344 PGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCN 403
            G + R  C A G P+PTV+W+ NGEPL S   N    +AGD + F    +    +YQC 
Sbjct: 340 IGSNLRWGCAAAGKPRPTVRWLRNGEPLASQ--NRVEVLAGD-LRFSKLSLEDSGMYQCV 396

Query: 404 TSNEHGYLLANAFVSVLDVPPRM-LSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNG 462
             N+HG + A+A ++V  + P   L+P  +LI         + C    +P   + W K G
Sbjct: 397 AENKHGTIYASAELAVQALAPDFRLNPVRRLIPAARGGEILIPCQPRAAPKAVVLWSK-G 455

Query: 463 QGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMP 522
               ++     V  +G+L I+ I + D+G YTC A N +GKA +   L V+D T+I   P
Sbjct: 456 TEILVNSSRVTVTPDGTLIIRNISRSDEGKYTCFAENFMGKANSTGILSVRDATKITLAP 515

Query: 523 EDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPL--------YIGNRMKKEDDSLTIF 574
                  G  + L+C   HDP++ LT +W  DD P+        Y    +K+    LTI 
Sbjct: 516 SSADINLGDNLTLQCHASHDPTMDLTFTWTLDDFPIDFDKPGGHYRRTNVKETIGDLTIL 575

Query: 575 GVAERDQGSYTCVASTELDQDLAKAYLTVLG 605
               R  G YTC+A T +D    +A + V G
Sbjct: 576 NAQLRHGGKYTCMAQTVVDSASKEATVLVRG 606



 Score = 83.2 bits (204), Expect = 6e-16
 Identities = 92/392 (23%), Positives = 160/392 (40%), Gaps = 41/392 (10%)

Query: 239 SFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDL---PSDKAKFENFNKAL 295
           S ++P+ +   Q+       LL C A   P     W   G ++   P  + +    N  +
Sbjct: 45  SVLFPEESTEEQV-------LLACRARASPPATYRWKMNGTEMKLEPGSRHQLVGGNLVI 97

Query: 296 RITNVSEEDSGEYFCLASNKMGSI--RHTISVRVKAAPYWLDEPKNLILA-PGEDGRLVC 352
            +     +D+G Y CLASN +G++  R  I +R      +  E ++ + A  G    L C
Sbjct: 98  -MNPTKAQDAGVYQCLASNPVGTVVSREAI-LRFGFLQEFSKEERDPVKAHEGWGVMLPC 155

Query: 353 RANGN-PKPTVQWMVNGEPLQSAPPNPNREVAGDT---IIFRDTQISSRAVYQCNTSNEH 408
               + P  + +W++N  P  +  P   R     T   +    T  S    Y C  ++  
Sbjct: 156 NPPAHYPGLSYRWLLNEFP--NFIPTDGRHFVSQTTGNLYIARTNASDLGNYSCLATSHM 213

Query: 409 GYLLANAF-----VSVLDVPPRMLSPRNQL-----IRVILYNRTRLDCPFFGSPIPTLRW 458
            +   + F     +++     R+ +P  +         ++  +  L+C  FG+P+P ++W
Sbjct: 214 DFSTKSVFSKFAQLNLAAEDTRLFAPSIKARFPAETYALVGQQVTLECFAFGNPVPRIKW 273

Query: 459 FKNGQGSNLDGGNYHVYENG--SLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPT 516
            K      +DG     +     +L+I  +  ED+G Y C A N  G+   Q R+ V+   
Sbjct: 274 RK------VDGSLSPQWTTAEPTLQIPSVSFEDEGTYECEAENSKGRDTVQGRIIVQAQP 327

Query: 517 RIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGV 576
              ++  D  A  G+ ++  C     P  + TV WL++ EPL   NR++     L    +
Sbjct: 328 EWLKVISDTEADIGSNLRWGCAAAGKP--RPTVRWLRNGEPLASQNRVEVLAGDLRFSKL 385

Query: 577 AERDQGSYTCVASTELDQDLAKAYLTVLGNCP 608
           +  D G Y CVA  +     A A L V    P
Sbjct: 386 SLEDSGMYQCVAENKHGTIYASAELAVQALAP 417



 Score = 72.4 bits (176), Expect = 1e-12
 Identities = 88/337 (26%), Positives = 125/337 (37%), Gaps = 59/337 (17%)

Query: 44  DHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRP 103
           D   D   N+   C A G P P+  W RN        +P  S + R   L  D R     
Sbjct: 335 DTEADIGSNLRWGCAAAGKPRPTVRWLRNG-------EPLAS-QNRVEVLAGDLRFSKLS 386

Query: 104 EEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPV----VVQEGAPLTLQCNPP 159
            E  G YQC A NK GT  ++    +++   L P   L+PV        G  + + C  P
Sbjct: 387 LEDSGMYQCVAENKHGTIYAS---AELAVQALAPDFRLNPVRRLIPAARGGEILIPCQ-P 442

Query: 160 PGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQ 219
              P  V+ W S   E +    RV+   +G L   N+   D +  Y+C     F      
Sbjct: 443 RAAPKAVVLW-SKGTEILVNSSRVTVTPDGTLIIRNISRSD-EGKYTC-----FAENFMG 495

Query: 220 KNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGG 279
           K   T  +L+ R   + T +        SS  +  G +L L+C AS  PT D+ +     
Sbjct: 496 KANST-GILSVRDATKITLA-------PSSADINLGDNLTLQCHASHDPTMDLTFTWTLD 547

Query: 280 DLPSDKAKFENFNKALRITNVSE------------EDSGEYFCLASNKMGSIRHTISVRV 327
           D P D   F+      R TNV E               G+Y C+A   + S     +V V
Sbjct: 548 DFPID---FDKPGGHYRRTNVKETIGDLTILNAQLRHGGKYTCMAQTVVDSASKEATVLV 604

Query: 328 KAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQW 364
           +               PG  G +V R  G+    + W
Sbjct: 605 RG-------------PPGPPGGVVVRDIGDTTIQLSW 628


>gi|28373117 contactin 1 isoform 1 precursor [Homo sapiens]
          Length = 1018

 Score =  219 bits (559), Expect = 4e-57
 Identities = 174/571 (30%), Positives = 250/571 (43%), Gaps = 47/571 (8%)

Query: 53  ILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYE--GEY 110
           + + C A+ +P P + W  N+   ++  D R SM    G LVI+      P++ +  G Y
Sbjct: 61  VSLNCRARASPFPVYKWRMNNGDVDLTSD-RYSMV--GGNLVIN-----NPDKQKDAGIY 112

Query: 111 QCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIF-W 169
            C A N +G   S    L       +P E    V V+EG  + L C+PP   P  + + W
Sbjct: 113 YCLASNNYGMVRSTEATLSFGYLDPFPPEERPEVRVKEGKGMVLLCDPPYHFPDDLSYRW 172

Query: 170 MSSSMEP-ITQDKR--VSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLK 226
           + +     IT DKR  VSQ  NG+LY +NV   D + +YSC     F  +         K
Sbjct: 173 LLNEFPVFITMDKRRFVSQT-NGNLYIANVEASD-KGNYSC-----FVSSPSITKSVFSK 225

Query: 227 VLTTRGVAERTPSFMYPQGTA---SSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPS 283
            +    + ERT    YP            L G ++ LEC A G P PDI W K    +PS
Sbjct: 226 FIPLIPIPERTTK-PYPADIVVQFKDVYALMGQNVTLECFALGNPVPDIRWRKVLEPMPS 284

Query: 284 DKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILA 343
             A+       L+I N+  ED G Y C A N  G  +H   + V+A P W++   +  + 
Sbjct: 285 T-AEISTSGAVLKIFNIQLEDEGIYECEAENIRGKDKHQARIYVQAFPEWVEHINDTEVD 343

Query: 344 PGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCN 403
            G D    C A G P PT++W+ NG               G+  ++ D    +  +YQC 
Sbjct: 344 IGSDLYWPCVATGKPIPTIRWLKNGYAYHK----------GELRLY-DVTFENAGMYQCI 392

Query: 404 TSNEHGYLLANAFVSVLDVPPRM-LSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNG 462
             N +G + ANA + +L + P   ++P  + I      R  ++C    +P P   W K G
Sbjct: 393 AENTYGAIYANAELKILALAPTFEMNPMKKKILAAKGGRVIIECKPKAAPKPKFSWSK-G 451

Query: 463 QGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMP 522
               ++     ++E+GSLEI  I + D GIYTC A N  GKA +   L + DPTRI   P
Sbjct: 452 TEWLVNSSRILIWEDGSLEINNITRNDGGIYTCFAENNRGKANSTGTLVITDPTRIILAP 511

Query: 523 EDQVARRGTTVQLECRVKHDPSLKLTVSW--------LKDDEPLYIGNRMKKEDDSLTIF 574
            +     G    ++C    DP+L LT  W           +   Y  N M   +  L I 
Sbjct: 512 INADITVGENATMQCAASFDPALDLTFVWSFNGYVIDFNKENIHYQRNFMLDSNGELLIR 571

Query: 575 GVAERDQGSYTCVASTELDQDLAKAYLTVLG 605
               +  G YTC A T +D   A A L V G
Sbjct: 572 NAQLKHAGRYTCTAQTIVDNSSASADLVVRG 602



 Score = 83.6 bits (205), Expect = 5e-16
 Identities = 88/365 (24%), Positives = 149/365 (40%), Gaps = 30/365 (8%)

Query: 260 LECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEE-DSGEYFCLASNKMGS 318
           L C A   P P   W    GD+     ++      L I N  ++ D+G Y+CLASN  G 
Sbjct: 63  LNCRARASPFPVYKWRMNNGDVDLTSDRYSMVGGNLVINNPDKQKDAGIYYCLASNNYGM 122

Query: 319 IRHTISVRVKAA--PYWLDEPKNLILAPGEDGRLVCRANGN--PKPTVQWMVNGEPLQSA 374
           +R T +        P+  +E   + +  G+   L+C    +     + +W++N  P+   
Sbjct: 123 VRSTEATLSFGYLDPFPPEERPEVRVKEGKGMVLLCDPPYHFPDDLSYRWLLNEFPV-FI 181

Query: 375 PPNPNREVA--GDTIIFRDTQISSRAVYQCNTSNEH-GYLLANAFVSVLDVPPRMLSPRN 431
             +  R V+     +   + + S +  Y C  S+      + + F+ ++ +P R   P  
Sbjct: 182 TMDKRRFVSQTNGNLYIANVEASDKGNYSCFVSSPSITKSVFSKFIPLIPIPERTTKPYP 241

Query: 432 QLIRV-------ILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGS-LEIK 483
             I V       ++     L+C   G+P+P +RW K  +          +  +G+ L+I 
Sbjct: 242 ADIVVQFKDVYALMGQNVTLECFALGNPVPDIRWRKVLEPMP---STAEISTSGAVLKIF 298

Query: 484 MIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDP 543
            I+ ED+GIY C A NI GK ++Q R+ V+          D     G+ +   C     P
Sbjct: 299 NIQLEDEGIYECEAENIRGKDKHQARIYVQAFPEWVEHINDTEVDIGSDLYWPCVATGKP 358

Query: 544 SLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTV 603
               T+ WLK+    + G         L ++ V   + G Y C+A        A A L +
Sbjct: 359 IP--TIRWLKNGYAYHKGE--------LRLYDVTFENAGMYQCIAENTYGAIYANAELKI 408

Query: 604 LGNCP 608
           L   P
Sbjct: 409 LALAP 413



 Score = 79.0 bits (193), Expect = 1e-14
 Identities = 110/472 (23%), Positives = 179/472 (37%), Gaps = 59/472 (12%)

Query: 66  SFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNR 125
           S+ W  N     I  D R  + + +G L I           +G Y CF  +   T   + 
Sbjct: 169 SYRWLLNEFPVFITMDKRRFVSQTNGNLYI----ANVEASDKGNYSCFVSSPSIT--KSV 222

Query: 126 IRLQVSKSPLWPKENLDP----VVVQ-------EGAPLTLQCNPPPGLPSPVIFWMSSSM 174
               +   P+ P+    P    +VVQ        G  +TL+C    G P P I W    +
Sbjct: 223 FSKFIPLIPI-PERTTKPYPADIVVQFKDVYALMGQNVTLECFAL-GNPVPDIRWRKV-L 279

Query: 175 EPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRGVA 234
           EP+     +S      L   N+ L+D +  Y C A       I+ K+    ++       
Sbjct: 280 EPMPSTAEISTS-GAVLKIFNIQLED-EGIYECEAE-----NIRGKDKHQARIYV----- 327

Query: 235 ERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKA 294
           +  P ++         +   G DL   C+A+G P P I W K G         +      
Sbjct: 328 QAFPEWVEHINDTEVDI---GSDLYWPCVATGKPIPTIRWLKNG---------YAYHKGE 375

Query: 295 LRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKA-APYWLDEPKNLILAPGEDGRLV-- 351
           LR+ +V+ E++G Y C+A N  G+I     +++ A AP +   P    +   + GR++  
Sbjct: 376 LRLYDVTFENAGMYQCIAENTYGAIYANAELKILALAPTFEMNPMKKKILAAKGGRVIIE 435

Query: 352 CRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGD--TIIFRDTQISSRAVYQCNTSNEHG 409
           C+    PKP   W    E L     N +R +  +  ++   +   +   +Y C   N  G
Sbjct: 436 CKPKAAPKPKFSWSKGTEWLV----NSSRILIWEDGSLEINNITRNDGGIYTCFAENNRG 491

Query: 410 YLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDG 469
              +   + + D    +L+P N  I V      +    F  +   T  W  NG   + + 
Sbjct: 492 KANSTGTLVITDPTRIILAPINADITVGENATMQCAASFDPALDLTFVWSFNGYVIDFNK 551

Query: 470 GNYHVYEN------GSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDP 515
            N H   N      G L I+  + +  G YTC A  I+  +     L V+ P
Sbjct: 552 ENIHYQRNFMLDSNGELLIRNAQLKHAGRYTCTAQTIVDNSSASADLVVRGP 603



 Score = 76.6 bits (187), Expect = 6e-14
 Identities = 91/386 (23%), Positives = 142/386 (36%), Gaps = 40/386 (10%)

Query: 25  IEIPMDLTQP-PTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPR 83
           I IP   T+P P       KD       N+ +EC A GNP P   W +      +   P 
Sbjct: 230 IPIPERTTKPYPADIVVQFKDVYALMGQNVTLECFALGNPVPDIRWRK-----VLEPMPS 284

Query: 84  VSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDP 143
            +    SG ++  F       E EG Y+C A N  G    ++ R+ V   P W  E+++ 
Sbjct: 285 TAEISTSGAVLKIFNI---QLEDEGIYECEAENIRGKD-KHQARIYVQAFPEW-VEHIND 339

Query: 144 VVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQT 203
             V  G+ L   C    G P P I W+          K     H G+L   +V  ++   
Sbjct: 340 TEVDIGSDLYWPC-VATGKPIPTIRWL----------KNGYAYHKGELRLYDVTFENAGM 388

Query: 204 DYSCNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECI 263
            Y C A   +           LK+L      E  P            +  +G  +++EC 
Sbjct: 389 -YQCIAENTYGAIYANAE---LKILALAPTFEMNP-------MKKKILAAKGGRVIIECK 437

Query: 264 ASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTI 323
               P P  +W K    L +        + +L I N++  D G Y C A N  G    T 
Sbjct: 438 PKAAPKPKFSWSKGTEWLVNSSRILIWEDGSLEINNITRNDGGIYTCFAENNRGKANSTG 497

Query: 324 SVRVKAAPYWLDEPKNLILAPGEDGRLVCRANGNP--KPTVQWMVNGEPLQSAPPNPNRE 381
           ++ +      +  P N  +  GE+  + C A+ +P    T  W  NG  +     N + +
Sbjct: 498 TLVITDPTRIILAPINADITVGENATMQCAASFDPALDLTFVWSFNGYVIDFNKENIHYQ 557

Query: 382 -----VAGDTIIFRDTQISSRAVYQC 402
                 +   ++ R+ Q+     Y C
Sbjct: 558 RNFMLDSNGELLIRNAQLKHAGRYTC 583



 Score = 50.8 bits (120), Expect = 4e-06
 Identities = 40/160 (25%), Positives = 69/160 (43%), Gaps = 8/160 (5%)

Query: 438 LYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVA 497
           L  +  L+C    SP P  +W  N    +L    Y +     +     +++D GIY C+A
Sbjct: 57  LEGKVSLNCRARASPFPVYKWRMNNGDVDLTSDRYSMVGGNLVINNPDKQKDAGIYYCLA 116

Query: 498 TNILG---KAENQVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKD 554
           +N  G     E  +     DP      PE +V + G  + L C   +     L+  WL +
Sbjct: 117 SNNYGMVRSTEATLSFGYLDPFPPEERPEVRV-KEGKGMVLLCDPPYHFPDDLSYRWLLN 175

Query: 555 DEPLYI----GNRMKKEDDSLTIFGVAERDQGSYTCVAST 590
           + P++I       + + + +L I  V   D+G+Y+C  S+
Sbjct: 176 EFPVFITMDKRRFVSQTNGNLYIANVEASDKGNYSCFVSS 215


>gi|28373119 contactin 1 isoform 2 precursor [Homo sapiens]
          Length = 1007

 Score =  219 bits (559), Expect = 4e-57
 Identities = 174/571 (30%), Positives = 250/571 (43%), Gaps = 47/571 (8%)

Query: 53  ILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYE--GEY 110
           + + C A+ +P P + W  N+   ++  D R SM    G LVI+      P++ +  G Y
Sbjct: 50  VSLNCRARASPFPVYKWRMNNGDVDLTSD-RYSMV--GGNLVIN-----NPDKQKDAGIY 101

Query: 111 QCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIF-W 169
            C A N +G   S    L       +P E    V V+EG  + L C+PP   P  + + W
Sbjct: 102 YCLASNNYGMVRSTEATLSFGYLDPFPPEERPEVRVKEGKGMVLLCDPPYHFPDDLSYRW 161

Query: 170 MSSSMEP-ITQDKR--VSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLK 226
           + +     IT DKR  VSQ  NG+LY +NV   D + +YSC     F  +         K
Sbjct: 162 LLNEFPVFITMDKRRFVSQT-NGNLYIANVEASD-KGNYSC-----FVSSPSITKSVFSK 214

Query: 227 VLTTRGVAERTPSFMYPQGTA---SSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPS 283
            +    + ERT    YP            L G ++ LEC A G P PDI W K    +PS
Sbjct: 215 FIPLIPIPERTTK-PYPADIVVQFKDVYALMGQNVTLECFALGNPVPDIRWRKVLEPMPS 273

Query: 284 DKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILA 343
             A+       L+I N+  ED G Y C A N  G  +H   + V+A P W++   +  + 
Sbjct: 274 T-AEISTSGAVLKIFNIQLEDEGIYECEAENIRGKDKHQARIYVQAFPEWVEHINDTEVD 332

Query: 344 PGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCN 403
            G D    C A G P PT++W+ NG               G+  ++ D    +  +YQC 
Sbjct: 333 IGSDLYWPCVATGKPIPTIRWLKNGYAYHK----------GELRLY-DVTFENAGMYQCI 381

Query: 404 TSNEHGYLLANAFVSVLDVPPRM-LSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNG 462
             N +G + ANA + +L + P   ++P  + I      R  ++C    +P P   W K G
Sbjct: 382 AENTYGAIYANAELKILALAPTFEMNPMKKKILAAKGGRVIIECKPKAAPKPKFSWSK-G 440

Query: 463 QGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMP 522
               ++     ++E+GSLEI  I + D GIYTC A N  GKA +   L + DPTRI   P
Sbjct: 441 TEWLVNSSRILIWEDGSLEINNITRNDGGIYTCFAENNRGKANSTGTLVITDPTRIILAP 500

Query: 523 EDQVARRGTTVQLECRVKHDPSLKLTVSW--------LKDDEPLYIGNRMKKEDDSLTIF 574
            +     G    ++C    DP+L LT  W           +   Y  N M   +  L I 
Sbjct: 501 INADITVGENATMQCAASFDPALDLTFVWSFNGYVIDFNKENIHYQRNFMLDSNGELLIR 560

Query: 575 GVAERDQGSYTCVASTELDQDLAKAYLTVLG 605
               +  G YTC A T +D   A A L V G
Sbjct: 561 NAQLKHAGRYTCTAQTIVDNSSASADLVVRG 591



 Score = 83.6 bits (205), Expect = 5e-16
 Identities = 88/365 (24%), Positives = 149/365 (40%), Gaps = 30/365 (8%)

Query: 260 LECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEE-DSGEYFCLASNKMGS 318
           L C A   P P   W    GD+     ++      L I N  ++ D+G Y+CLASN  G 
Sbjct: 52  LNCRARASPFPVYKWRMNNGDVDLTSDRYSMVGGNLVINNPDKQKDAGIYYCLASNNYGM 111

Query: 319 IRHTISVRVKAA--PYWLDEPKNLILAPGEDGRLVCRANGN--PKPTVQWMVNGEPLQSA 374
           +R T +        P+  +E   + +  G+   L+C    +     + +W++N  P+   
Sbjct: 112 VRSTEATLSFGYLDPFPPEERPEVRVKEGKGMVLLCDPPYHFPDDLSYRWLLNEFPV-FI 170

Query: 375 PPNPNREVA--GDTIIFRDTQISSRAVYQCNTSNEH-GYLLANAFVSVLDVPPRMLSPRN 431
             +  R V+     +   + + S +  Y C  S+      + + F+ ++ +P R   P  
Sbjct: 171 TMDKRRFVSQTNGNLYIANVEASDKGNYSCFVSSPSITKSVFSKFIPLIPIPERTTKPYP 230

Query: 432 QLIRV-------ILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGS-LEIK 483
             I V       ++     L+C   G+P+P +RW K  +          +  +G+ L+I 
Sbjct: 231 ADIVVQFKDVYALMGQNVTLECFALGNPVPDIRWRKVLEPMP---STAEISTSGAVLKIF 287

Query: 484 MIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDP 543
            I+ ED+GIY C A NI GK ++Q R+ V+          D     G+ +   C     P
Sbjct: 288 NIQLEDEGIYECEAENIRGKDKHQARIYVQAFPEWVEHINDTEVDIGSDLYWPCVATGKP 347

Query: 544 SLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTV 603
               T+ WLK+    + G         L ++ V   + G Y C+A        A A L +
Sbjct: 348 IP--TIRWLKNGYAYHKGE--------LRLYDVTFENAGMYQCIAENTYGAIYANAELKI 397

Query: 604 LGNCP 608
           L   P
Sbjct: 398 LALAP 402



 Score = 79.0 bits (193), Expect = 1e-14
 Identities = 110/472 (23%), Positives = 179/472 (37%), Gaps = 59/472 (12%)

Query: 66  SFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNR 125
           S+ W  N     I  D R  + + +G L I           +G Y CF  +   T   + 
Sbjct: 158 SYRWLLNEFPVFITMDKRRFVSQTNGNLYI----ANVEASDKGNYSCFVSSPSIT--KSV 211

Query: 126 IRLQVSKSPLWPKENLDP----VVVQ-------EGAPLTLQCNPPPGLPSPVIFWMSSSM 174
               +   P+ P+    P    +VVQ        G  +TL+C    G P P I W    +
Sbjct: 212 FSKFIPLIPI-PERTTKPYPADIVVQFKDVYALMGQNVTLECFAL-GNPVPDIRWRKV-L 268

Query: 175 EPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRGVA 234
           EP+     +S      L   N+ L+D +  Y C A       I+ K+    ++       
Sbjct: 269 EPMPSTAEISTS-GAVLKIFNIQLED-EGIYECEAE-----NIRGKDKHQARIYV----- 316

Query: 235 ERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKA 294
           +  P ++         +   G DL   C+A+G P P I W K G         +      
Sbjct: 317 QAFPEWVEHINDTEVDI---GSDLYWPCVATGKPIPTIRWLKNG---------YAYHKGE 364

Query: 295 LRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKA-APYWLDEPKNLILAPGEDGRLV-- 351
           LR+ +V+ E++G Y C+A N  G+I     +++ A AP +   P    +   + GR++  
Sbjct: 365 LRLYDVTFENAGMYQCIAENTYGAIYANAELKILALAPTFEMNPMKKKILAAKGGRVIIE 424

Query: 352 CRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGD--TIIFRDTQISSRAVYQCNTSNEHG 409
           C+    PKP   W    E L     N +R +  +  ++   +   +   +Y C   N  G
Sbjct: 425 CKPKAAPKPKFSWSKGTEWLV----NSSRILIWEDGSLEINNITRNDGGIYTCFAENNRG 480

Query: 410 YLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDG 469
              +   + + D    +L+P N  I V      +    F  +   T  W  NG   + + 
Sbjct: 481 KANSTGTLVITDPTRIILAPINADITVGENATMQCAASFDPALDLTFVWSFNGYVIDFNK 540

Query: 470 GNYHVYEN------GSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDP 515
            N H   N      G L I+  + +  G YTC A  I+  +     L V+ P
Sbjct: 541 ENIHYQRNFMLDSNGELLIRNAQLKHAGRYTCTAQTIVDNSSASADLVVRGP 592



 Score = 76.6 bits (187), Expect = 6e-14
 Identities = 91/386 (23%), Positives = 142/386 (36%), Gaps = 40/386 (10%)

Query: 25  IEIPMDLTQP-PTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPR 83
           I IP   T+P P       KD       N+ +EC A GNP P   W +      +   P 
Sbjct: 219 IPIPERTTKPYPADIVVQFKDVYALMGQNVTLECFALGNPVPDIRWRK-----VLEPMPS 273

Query: 84  VSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDP 143
            +    SG ++  F       E EG Y+C A N  G    ++ R+ V   P W  E+++ 
Sbjct: 274 TAEISTSGAVLKIFNI---QLEDEGIYECEAENIRGKD-KHQARIYVQAFPEW-VEHIND 328

Query: 144 VVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQT 203
             V  G+ L   C    G P P I W+          K     H G+L   +V  ++   
Sbjct: 329 TEVDIGSDLYWPC-VATGKPIPTIRWL----------KNGYAYHKGELRLYDVTFENAGM 377

Query: 204 DYSCNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECI 263
            Y C A   +           LK+L      E  P            +  +G  +++EC 
Sbjct: 378 -YQCIAENTYGAIYANAE---LKILALAPTFEMNP-------MKKKILAAKGGRVIIECK 426

Query: 264 ASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTI 323
               P P  +W K    L +        + +L I N++  D G Y C A N  G    T 
Sbjct: 427 PKAAPKPKFSWSKGTEWLVNSSRILIWEDGSLEINNITRNDGGIYTCFAENNRGKANSTG 486

Query: 324 SVRVKAAPYWLDEPKNLILAPGEDGRLVCRANGNP--KPTVQWMVNGEPLQSAPPNPNRE 381
           ++ +      +  P N  +  GE+  + C A+ +P    T  W  NG  +     N + +
Sbjct: 487 TLVITDPTRIILAPINADITVGENATMQCAASFDPALDLTFVWSFNGYVIDFNKENIHYQ 546

Query: 382 -----VAGDTIIFRDTQISSRAVYQC 402
                 +   ++ R+ Q+     Y C
Sbjct: 547 RNFMLDSNGELLIRNAQLKHAGRYTC 572



 Score = 50.8 bits (120), Expect = 4e-06
 Identities = 40/160 (25%), Positives = 69/160 (43%), Gaps = 8/160 (5%)

Query: 438 LYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVA 497
           L  +  L+C    SP P  +W  N    +L    Y +     +     +++D GIY C+A
Sbjct: 46  LEGKVSLNCRARASPFPVYKWRMNNGDVDLTSDRYSMVGGNLVINNPDKQKDAGIYYCLA 105

Query: 498 TNILG---KAENQVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKD 554
           +N  G     E  +     DP      PE +V + G  + L C   +     L+  WL +
Sbjct: 106 SNNYGMVRSTEATLSFGYLDPFPPEERPEVRV-KEGKGMVLLCDPPYHFPDDLSYRWLLN 164

Query: 555 DEPLYI----GNRMKKEDDSLTIFGVAERDQGSYTCVAST 590
           + P++I       + + + +L I  V   D+G+Y+C  S+
Sbjct: 165 EFPVFITMDKRRFVSQTNGNLYIANVEASDKGNYSCFVSS 204


>gi|7657361 contactin 6 [Homo sapiens]
          Length = 1028

 Score =  198 bits (503), Expect = 1e-50
 Identities = 155/568 (27%), Positives = 238/568 (41%), Gaps = 26/568 (4%)

Query: 50  RDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGE 109
           +  +++ C A G P+P + W +N    +         R   G+L I+       ++  G 
Sbjct: 43  KSEVILNCAANGYPSPHYRWKQNGTDIDFTMS--YHYRLDGGSLAIN---SPHTDQDIGM 97

Query: 110 YQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFW 169
           YQC A N  GT LS + +LQ +    +  +    V V+EG  + L C PPP        W
Sbjct: 98  YQCLATNLLGTILSRKAKLQFAYIEDFETKTRSTVSVREGQGVVLLCGPPPHFGDLSYAW 157

Query: 170 MSSSMEPITQD--KRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKV 227
             +      Q+  +R      G+LY + V   D+  +Y+C           Q  P  L  
Sbjct: 158 TFNDNPLYVQEDNRRFVSQETGNLYIAKVEPSDVG-NYTCFITNKEAQRSVQGPPTPLVQ 216

Query: 228 LTTRGVAERTPSF--MYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDK 285
            T   + E  P     +P+   ++    +   + LEC A G P PDI+W +  G     K
Sbjct: 217 RTDGVMGEYEPKIEVRFPETIQAA----KDSSVKLECFALGNPVPDISWRRLDGSPLPGK 272

Query: 286 AKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPG 345
            K+      L I N  +ED G Y C+ASN  G       +   A P W  + +N  L+  
Sbjct: 273 VKYSKSQAILEIPNFQQEDEGFYECIASNLRGRNLAKGQLIFYAPPEWEQKIQNTHLSIY 332

Query: 346 EDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTS 405
           ++    C+A+G P P   W+ NGE L    P    ++   T+I     +S   VYQC   
Sbjct: 333 DNLLWECKASGKPNPWYTWLKNGERLN---PEERIQIENGTLIITMLNVSDSGVYQCAAE 389

Query: 406 NEHGYLLANAFVSVL-DVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQG 464
           N++  + ANA + VL   P    SP  +   V +     + C     P   + W K G  
Sbjct: 390 NKYQIIYANAELRVLASAPDFSKSPVKKKSFVQVGGDIVIGCKPNAFPRAAISW-KRGTE 448

Query: 465 SNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPED 524
           +        + E+GSL+I  I + D G YTC+ATN  G A+N   L VK+ T I   P  
Sbjct: 449 TLRQSKRIFLLEDGSLKIYNITRSDAGSYTCIATNQFGTAKNTGSLIVKERTVITVPPSK 508

Query: 525 QVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMK-------KEDDSLTIFGVA 577
                G ++ L C+V HDPS+++   W  + + + +   +        +    L I  + 
Sbjct: 509 MDVTVGESIVLPCQVSHDPSIEVVFVWFFNGDVIDLKKGVAHFERIGGESVGDLMIRNIQ 568

Query: 578 ERDQGSYTCVASTELDQDLAKAYLTVLG 605
               G Y C   T L+   A A + V G
Sbjct: 569 LHHSGKYLCTVQTTLESLSAVADIIVRG 596



 Score = 90.9 bits (224), Expect = 3e-18
 Identities = 93/377 (24%), Positives = 156/377 (41%), Gaps = 38/377 (10%)

Query: 257 DLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNV--SEEDSGEYFCLASN 314
           +++L C A+G P+P   W + G D+    +     +      N   +++D G Y CLA+N
Sbjct: 45  EVILNCAANGYPSPHYRWKQNGTDIDFTMSYHYRLDGGSLAINSPHTDQDIGMYQCLATN 104

Query: 315 KMGSIRHTISVRVKAAPYWLD--EPKNLILAPGEDGRLVCRANGNPKP----TVQWMVNG 368
            +G+I   +S + K    +++  E K        +G+ V    G P      +  W  N 
Sbjct: 105 LLGTI---LSRKAKLQFAYIEDFETKTRSTVSVREGQGVVLLCGPPPHFGDLSYAWTFND 161

Query: 369 EPLQSAPPNPNREVAGDT--IIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVL------ 420
            PL     N  R V+ +T  +     + S    Y C  +N+          + L      
Sbjct: 162 NPLYVQEDN-RRFVSQETGNLYIAKVEPSDVGNYTCFITNKEAQRSVQGPPTPLVQRTDG 220

Query: 421 ---DVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYEN 477
              +  P++     + I+    +  +L+C   G+P+P + W +   GS L G   +    
Sbjct: 221 VMGEYEPKIEVRFPETIQAAKDSSVKLECFALGNPVPDISW-RRLDGSPLPGKVKYSKSQ 279

Query: 478 GSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTVQL-- 535
             LEI   ++ED+G Y C+A+N+ G      R   K     Y  PE +   + T + +  
Sbjct: 280 AILEIPNFQQEDEGFYECIASNLRG------RNLAKGQLIFYAPPEWEQKIQNTHLSIYD 333

Query: 536 ----ECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAERDQGSYTCVASTE 591
               EC+    P+   T  WLK+ E L    R++ E+ +L I  +   D G Y C A  +
Sbjct: 334 NLLWECKASGKPNPWYT--WLKNGERLNPEERIQIENGTLIITMLNVSDSGVYQCAAENK 391

Query: 592 LDQDLAKAYLTVLGNCP 608
                A A L VL + P
Sbjct: 392 YQIIYANAELRVLASAP 408



 Score = 79.3 bits (194), Expect = 9e-15
 Identities = 82/295 (27%), Positives = 119/295 (40%), Gaps = 43/295 (14%)

Query: 51  DNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEY 110
           DN+L EC+A G P P + W +N    N    P   ++  +GTL+I   +        G Y
Sbjct: 333 DNLLWECKASGKPNPWYTWLKNGERLN----PEERIQIENGTLIITMLNVSD----SGVY 384

Query: 111 QCFARNKFGTALSN-RIRL-----QVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPS 164
           QC A NK+    +N  +R+       SKSP+  K       VQ G  + + C P    P 
Sbjct: 385 QCAAENKYQIIYANAELRVLASAPDFSKSPVKKKS-----FVQVGGDIVIGCKPN-AFPR 438

Query: 165 PVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFT 224
             I W   + E + Q KR+    +G L   N+   D  + Y+C A   F          T
Sbjct: 439 AAISWKRGT-ETLRQSKRIFLLEDGSLKIYNITRSDAGS-YTCIATNQFG---------T 487

Query: 225 LKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIA--WYKKGG--D 280
            K   +  V ERT   + P    S   V  G  ++L C  S  P+ ++   W+  G   D
Sbjct: 488 AKNTGSLIVKERTVITVPP----SKMDVTVGESIVLPCQVSHDPSIEVVFVWFFNGDVID 543

Query: 281 LPSDKAKFENFNKA----LRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAP 331
           L    A FE         L I N+    SG+Y C     + S+     + V+  P
Sbjct: 544 LKKGVAHFERIGGESVGDLMIRNIQLHHSGKYLCTVQTTLESLSAVADIIVRGPP 598


>gi|193083163 roundabout, axon guidance receptor, homolog 2 isoform
           ROBO2a [Homo sapiens]
          Length = 1394

 Score =  192 bits (487), Expect = 1e-48
 Identities = 151/497 (30%), Positives = 223/497 (44%), Gaps = 35/497 (7%)

Query: 34  PPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRR--SG 91
           PP I +  + D IV   +   + C+A+G P P+  W ++       KD   S R    SG
Sbjct: 46  PPRIVEHPS-DVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSG 104

Query: 92  TLV-IDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGA 150
           +L  +    G R +  EG Y C ARN  G A+S    L+V+      ++N   VVV  G 
Sbjct: 105 SLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGE 164

Query: 151 PLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNAR 210
           P  L+C PP G P P I+W    +    +++R+S    G L  SN    D    Y+C   
Sbjct: 165 PAILECQPPRGHPEPTIYWKKDKVRIDDKEERISI-RGGKLMISNTRKSDAGM-YTCVG- 221

Query: 211 FHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTP 270
              T+ + +++    ++     V ER P+F+       +Q+VL    +   C   G P P
Sbjct: 222 ---TNMVGERDSDPAELT----VFER-PTFLR---RPINQVVLEEEAVEFRCQVQGDPQP 270

Query: 271 DIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAA 330
            + W K   DLP  +   ++ +  LRI      D G Y C+A N++G +  + ++ V+A 
Sbjct: 271 TVRWKKDDADLPRGRYDIKD-DYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAP 329

Query: 331 PYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGE-----PLQSAPPNPNREVA-- 383
           P ++  P++ I+A G      C   GNP+P V W   G      P Q   PN    V+  
Sbjct: 330 PQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPT 389

Query: 384 GDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDV-----PPRML-SPRNQLIRVI 437
           GD  I  + Q S    Y C      G +LA A + V DV     PP +L  P NQ + V 
Sbjct: 390 GDLTI-TNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAV- 447

Query: 438 LYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVA 497
                 L C   G P+P + W K G           + E G+L+IK +R  D G YTCVA
Sbjct: 448 -DGTALLKCKATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVA 506

Query: 498 TNILGKAENQVRLEVKD 514
           T+  G+      L+V +
Sbjct: 507 TSSSGETSWSAVLDVTE 523



 Score =  139 bits (349), Expect = 1e-32
 Identities = 108/379 (28%), Positives = 172/379 (45%), Gaps = 31/379 (8%)

Query: 248 SSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNV------- 300
           S  +V +G    L C A G PTP I WYK G  + +DK    +    L   ++       
Sbjct: 54  SDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSLFFLRIVH 113

Query: 301 ---SEEDSGEYFCLASNKMG-SIRHTISVRVKAA-PYWLDEPKNLILAPGEDGRLVCRA- 354
              S+ D G Y C+A N +G ++    S+ V      +   P ++++A GE   L C+  
Sbjct: 114 GRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGEPAILECQPP 173

Query: 355 NGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLAN 414
            G+P+PT+ W    + ++         + G  ++  +T+ S   +Y C  +N  G   ++
Sbjct: 174 RGHPEPTIYW--KKDKVRIDDKEERISIRGGKLMISNTRKSDAGMYTCVGTNMVGERDSD 231

Query: 415 -AFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYH 473
            A ++V + P  +  P NQ+  V+        C   G P PT+RW K+   ++L  G Y 
Sbjct: 232 PAELTVFERPTFLRRPINQV--VLEEEAVEFRCQVQGDPQPTVRWKKDD--ADLPRGRYD 287

Query: 474 VYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTV 533
           + ++ +L IK     D+G Y C+A N +GK E    L V+ P +    P DQ+  +G TV
Sbjct: 288 IKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRPRDQIVAQGRTV 347

Query: 534 QLECRVKHDPSLKLTVSWLKD-DEPLYIGNRMKKEDD--------SLTIFGVAERDQGSY 584
              C  K +P  +  V W K+  + L   N+ ++ +          LTI  +   D G Y
Sbjct: 348 TFPCETKGNP--QPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDAGYY 405

Query: 585 TCVASTELDQDLAKAYLTV 603
            C A T     LAKA L V
Sbjct: 406 ICQALTVAGSILAKAQLEV 424



 Score =  135 bits (340), Expect = 1e-31
 Identities = 132/505 (26%), Positives = 208/505 (41%), Gaps = 50/505 (9%)

Query: 127 RLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQG 186
           RL+    P    E+   V+V +G P TL C    G P+P I W     E +  DK   + 
Sbjct: 39  RLRQEDFPPRIVEHPSDVIVSKGEPTTLNCKAE-GRPTPTIEWYKDG-ERVETDKDDPRS 96

Query: 187 H-----NGDLYFSNVM----LQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRGVAERT 237
           H     +G L+F  ++     +  +  Y C AR +    + +    +L+V   R    + 
Sbjct: 97  HRMLLPSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNA--SLEVALLRDDFRQN 154

Query: 238 PSFMYPQGTASSQMVLRGMDLLLECIAS-GVPTPDIAWYKKGGDLPSDKAKFENFNKALR 296
           P+ +         +V  G   +LEC    G P P I W K    +   + +       L 
Sbjct: 155 PTDV---------VVAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLM 205

Query: 297 ITNVSEEDSGEYFCLASNKMGSI-RHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRAN 355
           I+N  + D+G Y C+ +N +G        + V   P +L  P N ++   E     C+  
Sbjct: 206 ISNTRKSDAGMYTCVGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQ 265

Query: 356 GNPKPTVQWMVNGEPLQSAPPNPNREVAGD-TIIFRDTQISSRAVYQCNTSNEHGYLLAN 414
           G+P+PTV+W  +   L    P    ++  D T+  + T  +    Y C   N  G + A+
Sbjct: 266 GDPQPTVRWKKDDADL----PRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEAS 321

Query: 415 AFVSVLDVPPRMLSPRNQLIRVILYNRT-RLDCPFFGSPIPTLRWFKNGQGSNL------ 467
           A ++V   P  ++ PR+Q   ++   RT    C   G+P P + W K G  + L      
Sbjct: 322 ATLTVRAPPQFVVRPRDQ---IVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQ 378

Query: 468 -DGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKD------PTRIYR 520
                  V   G L I  I++ D G Y C A  + G    + +LEV D      P  I +
Sbjct: 379 QPNSRCSVSPTGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQ 438

Query: 521 MPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDE--PLYIGNRMKKEDDSLTIFGVAE 578
            P +Q      T  L+C+   DP     +SWLK+    P        +E  +L I  +  
Sbjct: 439 GPANQTLAVDGTALLKCKATGDPLP--VISWLKEGFTFPGRDPRATIQEQGTLQIKNLRI 496

Query: 579 RDQGSYTCVASTELDQDLAKAYLTV 603
            D G+YTCVA++   +    A L V
Sbjct: 497 SDTGTYTCVATSSSGETSWSAVLDV 521



 Score = 37.0 bits (84), Expect = 0.053
 Identities = 34/139 (24%), Positives = 61/139 (43%), Gaps = 15/139 (10%)

Query: 12  AAFLLC-LLSLGGAI------EIPMDLT-QPPTITKQSAKDHIVDPRDNILIECEAKGNP 63
           A + +C  L++ G+I      E+   LT +PP I  Q   +  +      L++C+A G+P
Sbjct: 402 AGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKCKATGDP 461

Query: 64  APSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALS 123
            P   W +    F   +DPR +++ +    + + R         G Y C A +  G    
Sbjct: 462 LPVISWLKEGFTFP-GRDPRATIQEQGTLQIKNLRISD-----TGTYTCVATSSSGETSW 515

Query: 124 NRIRLQVSKSPLWPKENLD 142
           + + L V++S     +N D
Sbjct: 516 SAV-LDVTESGATISKNYD 533


>gi|61888896 roundabout, axon guidance receptor, homolog 2 isoform
           ROBO2b [Homo sapiens]
          Length = 1378

 Score =  192 bits (487), Expect = 1e-48
 Identities = 151/497 (30%), Positives = 223/497 (44%), Gaps = 35/497 (7%)

Query: 34  PPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRR--SG 91
           PP I +  + D IV   +   + C+A+G P P+  W ++       KD   S R    SG
Sbjct: 30  PPRIVEHPS-DVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSG 88

Query: 92  TLV-IDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGA 150
           +L  +    G R +  EG Y C ARN  G A+S    L+V+      ++N   VVV  G 
Sbjct: 89  SLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGE 148

Query: 151 PLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNAR 210
           P  L+C PP G P P I+W    +    +++R+S    G L  SN    D    Y+C   
Sbjct: 149 PAILECQPPRGHPEPTIYWKKDKVRIDDKEERISI-RGGKLMISNTRKSDAGM-YTCVG- 205

Query: 211 FHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTP 270
              T+ + +++    ++     V ER P+F+       +Q+VL    +   C   G P P
Sbjct: 206 ---TNMVGERDSDPAELT----VFER-PTFLR---RPINQVVLEEEAVEFRCQVQGDPQP 254

Query: 271 DIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAA 330
            + W K   DLP  +   ++ +  LRI      D G Y C+A N++G +  + ++ V+A 
Sbjct: 255 TVRWKKDDADLPRGRYDIKD-DYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAP 313

Query: 331 PYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGE-----PLQSAPPNPNREVA-- 383
           P ++  P++ I+A G      C   GNP+P V W   G      P Q   PN    V+  
Sbjct: 314 PQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPT 373

Query: 384 GDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDV-----PPRML-SPRNQLIRVI 437
           GD  I  + Q S    Y C      G +LA A + V DV     PP +L  P NQ + V 
Sbjct: 374 GDLTI-TNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAV- 431

Query: 438 LYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVA 497
                 L C   G P+P + W K G           + E G+L+IK +R  D G YTCVA
Sbjct: 432 -DGTALLKCKATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVA 490

Query: 498 TNILGKAENQVRLEVKD 514
           T+  G+      L+V +
Sbjct: 491 TSSSGETSWSAVLDVTE 507



 Score =  139 bits (349), Expect = 1e-32
 Identities = 108/379 (28%), Positives = 172/379 (45%), Gaps = 31/379 (8%)

Query: 248 SSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNV------- 300
           S  +V +G    L C A G PTP I WYK G  + +DK    +    L   ++       
Sbjct: 38  SDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSLFFLRIVH 97

Query: 301 ---SEEDSGEYFCLASNKMG-SIRHTISVRVKAA-PYWLDEPKNLILAPGEDGRLVCRA- 354
              S+ D G Y C+A N +G ++    S+ V      +   P ++++A GE   L C+  
Sbjct: 98  GRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGEPAILECQPP 157

Query: 355 NGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLAN 414
            G+P+PT+ W    + ++         + G  ++  +T+ S   +Y C  +N  G   ++
Sbjct: 158 RGHPEPTIYW--KKDKVRIDDKEERISIRGGKLMISNTRKSDAGMYTCVGTNMVGERDSD 215

Query: 415 -AFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYH 473
            A ++V + P  +  P NQ+  V+        C   G P PT+RW K+   ++L  G Y 
Sbjct: 216 PAELTVFERPTFLRRPINQV--VLEEEAVEFRCQVQGDPQPTVRWKKDD--ADLPRGRYD 271

Query: 474 VYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTV 533
           + ++ +L IK     D+G Y C+A N +GK E    L V+ P +    P DQ+  +G TV
Sbjct: 272 IKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRPRDQIVAQGRTV 331

Query: 534 QLECRVKHDPSLKLTVSWLKD-DEPLYIGNRMKKEDD--------SLTIFGVAERDQGSY 584
              C  K +P  +  V W K+  + L   N+ ++ +          LTI  +   D G Y
Sbjct: 332 TFPCETKGNP--QPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDAGYY 389

Query: 585 TCVASTELDQDLAKAYLTV 603
            C A T     LAKA L V
Sbjct: 390 ICQALTVAGSILAKAQLEV 408



 Score =  135 bits (340), Expect = 1e-31
 Identities = 132/505 (26%), Positives = 208/505 (41%), Gaps = 50/505 (9%)

Query: 127 RLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQG 186
           RL+    P    E+   V+V +G P TL C    G P+P I W     E +  DK   + 
Sbjct: 23  RLRQEDFPPRIVEHPSDVIVSKGEPTTLNCKAE-GRPTPTIEWYKDG-ERVETDKDDPRS 80

Query: 187 H-----NGDLYFSNVM----LQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRGVAERT 237
           H     +G L+F  ++     +  +  Y C AR +    + +    +L+V   R    + 
Sbjct: 81  HRMLLPSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNA--SLEVALLRDDFRQN 138

Query: 238 PSFMYPQGTASSQMVLRGMDLLLECIAS-GVPTPDIAWYKKGGDLPSDKAKFENFNKALR 296
           P+ +         +V  G   +LEC    G P P I W K    +   + +       L 
Sbjct: 139 PTDV---------VVAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLM 189

Query: 297 ITNVSEEDSGEYFCLASNKMGSI-RHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRAN 355
           I+N  + D+G Y C+ +N +G        + V   P +L  P N ++   E     C+  
Sbjct: 190 ISNTRKSDAGMYTCVGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQ 249

Query: 356 GNPKPTVQWMVNGEPLQSAPPNPNREVAGD-TIIFRDTQISSRAVYQCNTSNEHGYLLAN 414
           G+P+PTV+W  +   L    P    ++  D T+  + T  +    Y C   N  G + A+
Sbjct: 250 GDPQPTVRWKKDDADL----PRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEAS 305

Query: 415 AFVSVLDVPPRMLSPRNQLIRVILYNRT-RLDCPFFGSPIPTLRWFKNGQGSNL------ 467
           A ++V   P  ++ PR+Q   ++   RT    C   G+P P + W K G  + L      
Sbjct: 306 ATLTVRAPPQFVVRPRDQ---IVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQ 362

Query: 468 -DGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKD------PTRIYR 520
                  V   G L I  I++ D G Y C A  + G    + +LEV D      P  I +
Sbjct: 363 QPNSRCSVSPTGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQ 422

Query: 521 MPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDE--PLYIGNRMKKEDDSLTIFGVAE 578
            P +Q      T  L+C+   DP     +SWLK+    P        +E  +L I  +  
Sbjct: 423 GPANQTLAVDGTALLKCKATGDPLP--VISWLKEGFTFPGRDPRATIQEQGTLQIKNLRI 480

Query: 579 RDQGSYTCVASTELDQDLAKAYLTV 603
            D G+YTCVA++   +    A L V
Sbjct: 481 SDTGTYTCVATSSSGETSWSAVLDV 505



 Score = 37.0 bits (84), Expect = 0.053
 Identities = 34/139 (24%), Positives = 61/139 (43%), Gaps = 15/139 (10%)

Query: 12  AAFLLC-LLSLGGAI------EIPMDLT-QPPTITKQSAKDHIVDPRDNILIECEAKGNP 63
           A + +C  L++ G+I      E+   LT +PP I  Q   +  +      L++C+A G+P
Sbjct: 386 AGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKCKATGDP 445

Query: 64  APSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALS 123
            P   W +    F   +DPR +++ +    + + R         G Y C A +  G    
Sbjct: 446 LPVISWLKEGFTFP-GRDPRATIQEQGTLQIKNLRISD-----TGTYTCVATSSSGETSW 499

Query: 124 NRIRLQVSKSPLWPKENLD 142
           + + L V++S     +N D
Sbjct: 500 SAV-LDVTESGATISKNYD 517


>gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens]
          Length = 3783

 Score =  182 bits (463), Expect = 6e-46
 Identities = 165/587 (28%), Positives = 246/587 (41%), Gaps = 47/587 (8%)

Query: 34   PPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTR-NSRFFNIAKDPRVSMRRRSGT 92
            PPTI      D  V     +++ C + G PAP+  W++  ++        RVS    SG 
Sbjct: 2574 PPTIADDQT-DFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLGARGSGYRVSP---SGA 2629

Query: 93   LVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLW-PKENLDPVVVQEGAP 151
            L I    G     + G Y C ARN  G A    + L V  SP+  P  ++   V +E   
Sbjct: 2630 LEI----GQALPIHAGRYTCSARNSAGVA-HKHVFLTVQASPVVKPLPSVVRAVAEEEVL 2684

Query: 152  LTLQCNPPPGLPSPVIFWMSSSMEPITQ-DKRVSQGHNGDLYFSNVMLQDMQTDYSCNAR 210
            L  + +   G+P P I W    +   T    +V  G  G L  ++   +D   +Y C A 
Sbjct: 2685 LPCEAS---GIPRPTITWQKEGLNVATGVSTQVLPG--GQLRIAHASPEDAG-NYLCIA- 2737

Query: 211  FHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTP 270
                     KN     +  TR V +  P     +          G    L C A G P P
Sbjct: 2738 ---------KNSAGSAMGKTRLVVQVPPVI---ENGLPDLSTTEGSHAFLPCKARGSPEP 2785

Query: 271  DIAWYKKGGDLPSDKAKFE-NFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKA 329
            +I W K G  +   + KF    +  L + N+  +D+G Y C A N +G  R  + + +  
Sbjct: 2786 NITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRARRRVHLTILV 2845

Query: 330  APYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIF 389
             P +   P +  L  G+   L C A G+P P + W VN  P+       + +  G T+  
Sbjct: 2846 LPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEGV---SEQDGGSTLQR 2902

Query: 390  RDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFF 449
                      Y C   N  G   A +FV V + P       + L+  +     +LDC   
Sbjct: 2903 AAVSREDSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPV-GGSIQLDCVVR 2961

Query: 450  GSPIPTLRWFKNG---QGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAEN 506
            G P+P + W K+G   +GS+L     H  +NGSL I+   ++D G Y C+A N +G A+ 
Sbjct: 2962 GDPVPDIHWIKDGLPLRGSHLR----HQLQNGSLTIRRTERDDAGRYQCLAENEMGVAKK 3017

Query: 507  QVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKK 566
             V L ++        P+D   R G  V L C+   +P+   T+ WL+  +PL    R++ 
Sbjct: 3018 VVILVLQSAPVFQVEPQDMTVRSGDDVALRCQATGEPT--PTIEWLQAGQPLRASRRLRT 3075

Query: 567  -EDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTVLGNCPCSPW 612
              D SL +  V   D G+Y CVA   L    A+A+L V G  P   W
Sbjct: 3076 LPDGSLWLENVETGDAGTYDCVAHNLLGSATARAFLVVRGE-PQGSW 3121



 Score =  157 bits (396), Expect = 4e-38
 Identities = 153/604 (25%), Positives = 252/604 (41%), Gaps = 55/604 (9%)

Query: 35   PTI---TKQSAKDHIVDPRDN-ILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRS 90
            PTI    + SA + +    +N I + CEA   P+P+  W ++   F  +++ ++ +    
Sbjct: 1255 PTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGAPFEASRNIQL-LPGTH 1313

Query: 91   GTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNR-----IRLQVSKSPLWPKENLDPVV 145
            G  +++ +     +E  G+Y C   N+ G A+ N      I   +SK     +  +  V 
Sbjct: 1314 GLQILNAQ-----KEDAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLAEVGVKEVK 1368

Query: 146  VQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDY 205
             +  + LTL+C     +P P I W     +P+T   R+     G L      LQ   T  
Sbjct: 1369 TKVNSTLTLECESW-AVPPPTIRWYKDG-QPVTPSSRLQVLGEGRL------LQIQPTQV 1420

Query: 206  SCNARFHFTHT------------IQQKNPFTLKVLTTRGVAERTPSFMYPQGTASS-QMV 252
            S + R+    T            + Q  P   KV       E        +G  +  + +
Sbjct: 1421 SDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREI 1480

Query: 253  LRGMDLLLECIASGVPTPDIAWYKKGGDLPS-DKAKFENFNKALRITNVSEEDSGEYFCL 311
            +      L C  + +P PD+ WY++   L + D+       + L+I  V  E++G Y C 
Sbjct: 1481 VENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCK 1540

Query: 312  ASNKMGSIRHTISVRVKAAPYWLDEPKNLI----LAPGEDGRLVCRANGNPKPTVQWMVN 367
            ASN++G       + V   P  L + + L+    +       L C A GNP PT+ W+ N
Sbjct: 1541 ASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQN 1600

Query: 368  GEPLQSAPPNPNREVAGDTIIFR--DTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPR 425
            G P     P+P  +V  D  + +    +++  A Y C   N+ G      F   + VPPR
Sbjct: 1601 GLPFS---PSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSA-EKLFTLRVQVPPR 1656

Query: 426  MLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMI 485
            +     + +  IL +   L C     P P + W+K+ Q  +L    + +    +L++   
Sbjct: 1657 IAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGTHTLQLGRA 1716

Query: 486  RKEDQGIYTCVATNILGKAENQVRLEVKDP---TRIYRMPEDQV-ARRGTTVQLECRVKH 541
            R  D G+YTC A N  G+ +  V+L V  P    +  R P+D V  R G    L C    
Sbjct: 1717 RLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCET-- 1774

Query: 542  DPSLKLTVSWLKDDEPLYIGNRMK--KEDDSLTIFGVAERDQGSYTCVASTELDQDLAKA 599
            D   + TV+W KD +PL +  R +  +    L I      D+G Y+C  S    + +   
Sbjct: 1775 DALPEPTVTWYKDGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTF 1834

Query: 600  YLTV 603
             LTV
Sbjct: 1835 TLTV 1838



 Score =  156 bits (394), Expect = 6e-38
 Identities = 152/563 (26%), Positives = 234/563 (41%), Gaps = 70/563 (12%)

Query: 51   DNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYE--- 107
            D  ++ CE    P P+  W ++ +       P V  +R         R G R E  E   
Sbjct: 1766 DKAVLSCETDALPEPTVTWYKDGQ-------PLVLAQRTQA-----LRGGQRLEIQEAQV 1813

Query: 108  ---GEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPS 164
               G Y C   N  G A+     L V   P +     + V    G+PL L C+   G+P+
Sbjct: 1814 SDKGLYSCKVSNVAGEAVRT-FTLTVQVPPTFENPKTETVSQVAGSPLVLTCDVS-GVPA 1871

Query: 165  PVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFT 224
            P + W+   M   +          G L  S +      T Y+C A        + +  F 
Sbjct: 1872 PTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGT-YTCVAE---NTQAEARKDFV 1927

Query: 225  LKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSD 284
            + VL    VA R  S     G A    VL G ++ L+C A G P PD+AW K G  L  D
Sbjct: 1928 VAVL----VAPRIRS----SGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQD 1979

Query: 285  KAKFENF---NKALRITNVSEEDSGEYFCLASNKMG--SIRHTISVRV-KAAPYWLDEPK 338
                  F     +L +  +   D+G Y C+A N  G  +  HT++V V        D   
Sbjct: 1980 MGPHLRFYLDGGSLVLKGLRASDAGAYTCVAHNPAGEDARLHTVNVLVPPTIKQGADGSG 2039

Query: 339  NLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREV---AGDTIIFRDTQIS 395
             L+  PGE   +VC   G+P   V W+ +G PL    P   R +   +G T+     Q++
Sbjct: 2040 TLVSRPGELVTMVCPVRGSPPIHVSWLKDGLPL----PLSQRTLLHGSGHTLRISKVQLA 2095

Query: 396  SRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSP---RNQLIRVILYNRTRLDCPFFGSP 452
               ++ C  ++  G    N F   + VPP +L P   +N ++ V+  +   L C   G P
Sbjct: 2096 DAGIFTCVAASPAGVADRN-FTLQVQVPP-VLEPVEFQNDVV-VVRGSLVELPCEARGVP 2152

Query: 453  IPTLRWFKNGQ---GSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVR 509
            +P + W K+G+     +L+ G        SL+++ +   D G Y+CVA +  G+A    +
Sbjct: 2153 LPLVSWMKDGEPLLSQSLEQG-------PSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQ 2205

Query: 510  LEVKDPTRI--YRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKE 567
            L V +P  I     P +     G  ++L C  +  P   +T  W KD + L      + E
Sbjct: 2206 LTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNIT--WHKDGQAL-----TRLE 2258

Query: 568  DDSLTIFGVAERDQGSYTCVAST 590
            ++S     +  RD G YTC+A +
Sbjct: 2259 NNSRATRVLRVRDAGLYTCLAES 2281



 Score =  151 bits (382), Expect = 1e-36
 Identities = 149/571 (26%), Positives = 230/571 (40%), Gaps = 37/571 (6%)

Query: 34   PPTI---TKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRS 90
            PP I   T++  ++  V+    + ++C A GNP P+  W +N   F+    PR+ +    
Sbjct: 1559 PPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFS--PSPRLQVLEDG 1616

Query: 91   GTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGA 150
              L +              Y C A N+ G+A      L+V   P     +L+ V     +
Sbjct: 1617 QVLQVSTAEVADA----ASYMCVAENQAGSA-EKLFTLRVQVPPRIAGLDLEQVTAILNS 1671

Query: 151  PLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNAR 210
             ++L C+     P+P + W   S      ++         L      L D    Y+C A 
Sbjct: 1672 SVSLPCDVHAH-PNPEVTWYKDSQALSLGEEVFLLPGTHTLQLGRARLSDSGM-YTCEA- 1728

Query: 211  FHFTHTIQQKNPFTLKVLTTRGVAERTPSFMY-PQGTASSQMVLRGMDLLLECIASGVPT 269
                   + +    L VL         P+F   P+G   + +V  G   +L C    +P 
Sbjct: 1729 --LNAAGRDQKLVQLSVLVP-------PAFRQAPRGPQDAVLVRVGDKAVLSCETDALPE 1779

Query: 270  PDIAWYKKGGDLP-SDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVK 328
            P + WYK G  L  + + +     + L I      D G Y C  SN  G    T ++ V+
Sbjct: 1780 PTVTWYKDGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQ 1839

Query: 329  AAPYWLDEPKNLILA--PGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDT 386
              P + + PK   ++   G    L C  +G P PTV W+ +  P++S+  +      G  
Sbjct: 1840 VPPTF-ENPKTETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPVESSAVHGVVSRGGRL 1898

Query: 387  IIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDC 446
             + R  Q +    Y C   N       +  V+VL  P    S   +   V+     RLDC
Sbjct: 1899 QLSR-LQPAQAGTYTCVAENTQAEARKDFVVAVLVAPRIRSSGVAREHHVLEGQEVRLDC 1957

Query: 447  PFFGSPIPTLRWFKNGQGSNLDGGNY--HVYENGSLEIKMIRKEDQGIYTCVATNILGKA 504
               G P P + W K+G     D G +     + GSL +K +R  D G YTCVA N  G+ 
Sbjct: 1958 EADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVAHNPAGED 2017

Query: 505  ENQVRLEVKDPTRIYRMPEDQ---VARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIG 561
                 + V  P  I +  +     V+R G  V + C V+  P +   VSWLKD  PL + 
Sbjct: 2018 ARLHTVNVLVPPTIKQGADGSGTLVSRPGELVTMVCPVRGSPPIH--VSWLKDGLPLPLS 2075

Query: 562  NR--MKKEDDSLTIFGVAERDQGSYTCVAST 590
             R  +     +L I  V   D G +TCVA++
Sbjct: 2076 QRTLLHGSGHTLRISKVQLADAGIFTCVAAS 2106



 Score =  151 bits (381), Expect = 2e-36
 Identities = 150/606 (24%), Positives = 243/606 (40%), Gaps = 58/606 (9%)

Query: 19   LSLGGAIEIPMDLTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNI 78
            L  G  + +P  +T PP++         V     + + C A G P+P+  W ++    + 
Sbjct: 685  LRYGLRVNVPPRITLPPSLPGP------VLVNTPVRLTCNATGAPSPTLMWLKDGNPVSP 738

Query: 79   AKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPK 138
            A  P + +      L +   +  R  +  G Y C A +  G    + + LQV   P    
Sbjct: 739  AGTPGLQVFPGGRVLTL---ASARASD-SGRYSCVAVSAVGEDRQDVV-LQVHMPPSILG 793

Query: 139  ENLD-PVVVQEGAPLTLQCNPPPGLPSPVIFWMSSS--MEP-----ITQDKRVSQGHNGD 190
            E L+  VV  E   L  Q +    +P PV+ W      +EP     ++ DK + Q    D
Sbjct: 794  EELNVSVVANESVALECQSH---AMPPPVLSWWKDGRPLEPRPGVHLSADKALLQVDRAD 850

Query: 191  LYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQ 250
            ++ +          Y+C A     H+ +  N   L V             ++P   + + 
Sbjct: 851  VWDAG--------HYTCEALNQAGHSEKHYN---LNVWVAP---------VFPLRESHTL 890

Query: 251  MVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEED---SGE 307
             V  G    L C   GVP P I+W K G  LP + A  ++ +   R+  + +      G 
Sbjct: 891  TVREGHPTRLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGT 950

Query: 308  YFCLASNKMGSIRHTISVRVKAAPYWL---DEPKNLILAPGEDGRLVCRANGNPKPTVQW 364
            Y C  SN +G+    + + V   P      + P  + +       L C A G P PTV W
Sbjct: 951  YTCECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTW 1010

Query: 365  MVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPP 424
              +G+P+  A      +  G ++     Q +    Y C   N  G       +SVL VPP
Sbjct: 1011 ERDGQPV-GAELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVL-VPP 1068

Query: 425  RMLSPRNQL--IRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEI 482
             ++   + L  I   L++   L C   G P P +RWF+  +  +     Y +     L++
Sbjct: 1069 ELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGWMLKM 1128

Query: 483  KMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVAR--RGTTVQLECRVK 540
               +++D G+Y+C+A+N  G+A     +EV  P  I     ++V +   G T  L C V 
Sbjct: 1129 TQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVT 1188

Query: 541  HDPSLKLTVSWLKDDEPLYIGNRMKKEDDS--LTIFGVAERDQGSYTCVASTELDQDLAK 598
              P  KLT  W KD  PL  G+      D   L +        G Y+C+A+  + +    
Sbjct: 1189 GHPQPKLT--WFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKH 1246

Query: 599  AYLTVL 604
              L+VL
Sbjct: 1247 FQLSVL 1252



 Score =  150 bits (380), Expect = 3e-36
 Identities = 144/580 (24%), Positives = 228/580 (39%), Gaps = 37/580 (6%)

Query: 31   LTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRS 90
            L  P   +   A++H V     + ++CEA G P P   W ++         P +      
Sbjct: 1931 LVAPRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDG 1990

Query: 91   GTLVIDFRSGGRPEEYEGEYQCFARNKFG-TALSNRIRLQVSKSPLWPKENLDPVVVQEG 149
            G+LV+     G      G Y C A N  G  A  + + + V  +     +    +V + G
Sbjct: 1991 GSLVLK----GLRASDAGAYTCVAHNPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRPG 2046

Query: 150  APLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNA 209
              +T+ C P  G P   + W+   +      + +  G    L  S V L D    ++C A
Sbjct: 2047 ELVTMVC-PVRGSPPIHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGI-FTCVA 2104

Query: 210  RFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPT 269
                   +  +N FTL+V        + P  + P    +  +V+RG  + L C A GVP 
Sbjct: 2105 A--SPAGVADRN-FTLQV--------QVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPL 2153

Query: 270  PDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKA 329
            P ++W K G  L S   +      +L++  V   DSG Y C+A ++ G  R    + V  
Sbjct: 2154 PLVSWMKDGEPLLSQSLE---QGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVME 2210

Query: 330  APYWLD--EPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTI 387
             P+  D  +P  L L PG    L+C A G P+P + W  +G+ L     N          
Sbjct: 2211 PPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQALTRLENNSRAT------ 2264

Query: 388  IFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRN-QLIRVILYNRTRLDC 446
              R  ++    +Y C   +  G  +  +F   +  PP ++ PR  + +  +   +  L+C
Sbjct: 2265 --RVLRVRDAGLYTCLAESPAG-AIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLVLEC 2321

Query: 447  PFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAEN 506
                 P P + W ++G     D           L+++ +   D G Y+C A N  G    
Sbjct: 2322 SVEAEPAPKITWHRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSV 2381

Query: 507  QVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKK 566
              R+E+     I   P         T  L C+    P+    VSW KD  PL   +   +
Sbjct: 2382 AFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPA--PLVSWRKDRVPLDPRSPRFE 2439

Query: 567  --EDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTVL 604
               + SL I  V  +D G Y C+AS     D     L VL
Sbjct: 2440 ILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVL 2479



 Score =  149 bits (376), Expect = 7e-36
 Identities = 151/580 (26%), Positives = 225/580 (38%), Gaps = 38/580 (6%)

Query: 29   MDLTQPPTITKQSAKDHI-VDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMR 87
            + + +PP I        + + P   + + C+A+G P P+  W ++ +        R+   
Sbjct: 2206 LTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQALT-----RLENN 2260

Query: 88   RRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTA-LSNRIRLQVSKSPLWPKENLDPVVV 146
             R+ T V+  R  G        Y C A +  G    S R+R+Q   + + P+     V +
Sbjct: 2261 SRA-TRVLRVRDAGL-------YTCLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGL 2312

Query: 147  QEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYS 206
              G  L L+C+     P+P I W    +  + +D        G       +      DYS
Sbjct: 2313 APGQ-LVLECSVEAE-PAPKITWHRDGIV-LQEDAHTQFPERGRFLQLQALSTADSGDYS 2369

Query: 207  CNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASG 266
            C AR     T      F +++ T   +    P+            V      LL C A G
Sbjct: 2370 CTARNAAGST---SVAFRVEIHTVPTIRSGPPAVN----------VSVNQTALLPCQADG 2416

Query: 267  VPTPDIAWYKKGGDLPSDKAKFENFNK-ALRITNVSEEDSGEYFCLASNKMGSIRHTISV 325
            VP P ++W K    L     +FE   + +LRI  V  +D+G Y CLASN  GS R    +
Sbjct: 2417 VPAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDL 2476

Query: 326  RVKAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQ-SAPPNPNREVAG 384
            RV   P     P NL L       L C A+G+PKP V W  +G+ L         R +  
Sbjct: 2477 RVLEPPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPS 2536

Query: 385  DTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRL 444
            + ++         A ++C  SNE G      +   + VPP +   +     V +     L
Sbjct: 2537 NALLLTAPGPQDSAQFECVVSNEVGE-AHRLYQVTVHVPPTIADDQTD-FTVTMMAPVVL 2594

Query: 445  DCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKA 504
             C   G P PT+ W K G      G  Y V  +G+LEI        G YTC A N  G A
Sbjct: 2595 TCHSTGIPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGVA 2654

Query: 505  ENQVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIG-NR 563
               V L V+    +  +P    A     V L C     P  + T++W K+   +  G + 
Sbjct: 2655 HKHVFLTVQASPVVKPLPSVVRAVAEEEVLLPCEASGIP--RPTITWQKEGLNVATGVST 2712

Query: 564  MKKEDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTV 603
                   L I   +  D G+Y C+A       + K  L V
Sbjct: 2713 QVLPGGQLRIAHASPEDAGNYLCIAKNSAGSAMGKTRLVV 2752



 Score =  144 bits (364), Expect = 2e-34
 Identities = 146/562 (25%), Positives = 225/562 (40%), Gaps = 45/562 (8%)

Query: 55   IECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFA 114
            + CE +G P P   W ++ +     +   +      G L+     G      EG Y C  
Sbjct: 900  LSCECRGVPFPKISWRKDGQPLP-GEGAGLQHVSAVGRLLY---LGQAQLAQEGTYTCEC 955

Query: 115  RNKFGTALSNRIRLQVSKSP--LWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSS 172
             N  G + S  ++L+V   P    P+E    V V +    TL+CN   G P P + W   
Sbjct: 956  SNVVGNS-SQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNAT-GKPPPTVTWERD 1013

Query: 173  SMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRG 232
              +P+  +  +   + G               YSC A  +     ++K  F L VL    
Sbjct: 1014 G-QPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAE-NLAGRAERK--FELSVLVP-- 1067

Query: 233  VAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDL-PSDKAKFENF 291
                 P  +      ++        L L C A G+P P I W++    + P +       
Sbjct: 1068 -----PELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAG 1122

Query: 292  NKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILA--PGEDGR 349
               L++T   E+DSG Y CLASN+ G  R   SV V   P   +E    ++    G+   
Sbjct: 1123 GWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAH 1182

Query: 350  LVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQ--ISSRAVYQCNTSNE 407
            L+C   G+P+P + W  +G PL     +    ++ D ++ +  Q  +SS   Y C  +N 
Sbjct: 1183 LMCNVTGHPQPKLTWFKDGRPLARGDAH---HISPDGVLLQVLQANLSSAGHYSCIAANA 1239

Query: 408  HGYLLANAFVSVLDVPPRMLSPRNQL---IRVILYNRTRLDCPFFGSPIPTLRWFKNGQG 464
             G    +  +SVL  P  +    +     + V + N   L C     P P + W K+G  
Sbjct: 1240 VGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGAP 1299

Query: 465  SNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPED 524
                     +     L+I   +KED G YTCV TN LG+A     +EV  P  I +  +D
Sbjct: 1300 FEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSISK--DD 1357

Query: 525  QVARRG---------TTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMK--KEDDSLTI 573
             +A  G         +T+ LEC     P    T+ W KD +P+   +R++   E   L I
Sbjct: 1358 PLAEVGVKEVKTKVNSTLTLECESWAVP--PPTIRWYKDGQPVTPSSRLQVLGEGRLLQI 1415

Query: 574  FGVAERDQGSYTCVASTELDQD 595
                  D G Y CVA+    +D
Sbjct: 1416 QPTQVSDSGRYLCVATNVAGED 1437



 Score =  143 bits (361), Expect = 4e-34
 Identities = 154/581 (26%), Positives = 236/581 (40%), Gaps = 47/581 (8%)

Query: 31  LTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRS 90
           LT P  +   +A++ +     ++ ++C   G P P   WT++ R   +   P + ++   
Sbjct: 122 LTPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTKD-RQPVLPGGPHLQVQEDG 180

Query: 91  GTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSP-LWPKENLDPVVVQEG 149
             L    R  G     EG YQC A +  G   +   +L+V   P +W       V V E 
Sbjct: 181 QVL----RITGSHVGDEGRYQCVAFSPAGQQ-ARDFQLRVHAPPTIWGSNETGEVAVMED 235

Query: 150 APLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNA 209
             + L C    G+P+P I W        T  K V       L        D    Y+C A
Sbjct: 236 HLVQLLCE-ARGVPTPNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGV-YTCKA 293

Query: 210 RFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPT 269
                      N        TR      P+     G       + G  + LEC+A G P+
Sbjct: 294 ----------SNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPS 343

Query: 270 PDIAWYKKGGDLP---SDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVR 326
           P ++W+ +G  LP   S++++ E     LR+ +  E  SG Y C+AS+  G      SV 
Sbjct: 344 PTLSWHHEG--LPVAESNESRLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVE 401

Query: 327 VKAAPYWL--DEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVA- 383
           V+  P  L  +    +    G+   L C+A+G+P PT+QW+ NG P +        +VA 
Sbjct: 402 VQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGRPAEEL---AGVQVAS 458

Query: 384 -GDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLD--VPPRMLSPRNQLIRVILYN 440
            G T+     ++    ++ C  +NE G   A   VSV     P  +  P  Q      ++
Sbjct: 459 QGTTLHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHH 518

Query: 441 RT---RLDCP----FFGSPIPTL--RWFKNGQGSNLDGGNYHVYE-NGSLEIKMIRKEDQ 490
            +     D P    +   P P L   W   G       G    Y     L+I+ +   D+
Sbjct: 519 SSFPAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLPPPLQIEKVDLRDE 578

Query: 491 GIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVS 550
           GIYTC ATN+ G+++ +V L+V  P  I   P ++      +V LEC     P     VS
Sbjct: 579 GIYTCAATNLAGESKREVALKVLVPPNIEPGPVNKAVLENASVTLECLASGVP--PPDVS 636

Query: 551 WLKDDEPL--YIGNRMKKEDDSLTIFGVAERDQGSYTCVAS 589
           W K  +P+  ++G  +  +   L I      D GSY CVAS
Sbjct: 637 WFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVAS 677



 Score =  140 bits (353), Expect = 3e-33
 Identities = 150/598 (25%), Positives = 241/598 (40%), Gaps = 84/598 (14%)

Query: 55   IECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFA 114
            +EC A G P P+  W R+ +   +  +  + ++ +  +L ++         + G Y C A
Sbjct: 996  LECNATGKPPPTVTWERDGQ--PVGAELGLQLQNQGQSLHVERAQAA----HTGRYSCVA 1049

Query: 115  RNKFGTALSNRIRLQVSKSPLWPKE---NLDPVVVQEGA---PLTLQCNPPPGLPSPVIF 168
             N     L+ R   +   S L P E   +LDP+     A   PLTL C    G+P P I 
Sbjct: 1050 EN-----LAGRAERKFELSVLVPPELIGDLDPLTNITAALHSPLTLLCEAM-GIPPPAIR 1103

Query: 169  WMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTD------YSCNARFHFTHTIQQKNP 222
            W     EP      VS G +  L     ML+  QT       YSC A        + +  
Sbjct: 1104 WFRGE-EP------VSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLAS---NEAGEARRN 1153

Query: 223  FTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLP 282
            F+++VL         P  +  +       VL G    L C  +G P P + W+K G  L 
Sbjct: 1154 FSVEVLV--------PPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLA 1205

Query: 283  -SDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWL-----DE 336
              D          L++   +   +G Y C+A+N +G       + V  AP  L       
Sbjct: 1206 RGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPTILGGAEDSA 1265

Query: 337  PKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDT--IIFRDTQI 394
             + + +       L+C A   P P + WM +G P +++    N ++   T  +   + Q 
Sbjct: 1266 DEEVTVTVNNPISLICEALAFPSPNITWMKDGAPFEASR---NIQLLPGTHGLQILNAQK 1322

Query: 395  SSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLS--PRNQL----IRVILYNRTRLDCPF 448
                 Y C  +NE G  + N  V VL +PP +    P  ++    ++  + +   L+C  
Sbjct: 1323 EDAGQYTCVVTNELGEAVKNYHVEVL-IPPSISKDDPLAEVGVKEVKTKVNSTLTLECES 1381

Query: 449  FGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQV 508
            +  P PT+RW+K+GQ          + E   L+I+  +  D G Y CVATN+ G+ +   
Sbjct: 1382 WAVPPPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDF 1441

Query: 509  RLEVKDPTRIYR----------MPEDQVARRGTT----------VQLECRVKHDPSLKLT 548
             + ++ P    +          +  ++ AR G T            L C     P   LT
Sbjct: 1442 NVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLT 1501

Query: 549  VSWLKDDEPLYIGNRMK--KEDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTVL 604
              W ++D+PL  G+ +   +    L I  V   + G Y+C AS E+ +D     L VL
Sbjct: 1502 --WYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVGEDWLHYELLVL 1557



 Score =  139 bits (350), Expect = 8e-33
 Identities = 148/586 (25%), Positives = 235/586 (40%), Gaps = 54/586 (9%)

Query: 26   EIPMDLTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVS 85
            E+ + +  PP I        +++   ++ +EC A G P P   W +  +  +      VS
Sbjct: 595  EVALKVLVPPNIEPGPVNKAVLE-NASVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVS 653

Query: 86   MRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFG-TALSNRIRLQVSKSPLWPKENLDPV 144
            +  R    V+        +   G Y+C A N  G T L   +R+ V      P     PV
Sbjct: 654  VDGR----VLRIEQAQLSD--AGSYRCVASNVAGSTELRYGLRVNVPPRITLPPSLPGPV 707

Query: 145  VVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPI----TQDKRVSQGHNGDLYFSNVMLQD 200
            +V    P+ L CN   G PSP + W+     P+    T   +V  G    L  ++    D
Sbjct: 708  LV--NTPVRLTCN-ATGAPSPTLMWLKDG-NPVSPAGTPGLQVFPG-GRVLTLASARASD 762

Query: 201  MQTDYSCNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLL 260
                YSC A    +   + +    L+V          PS +   G   +  V+    + L
Sbjct: 763  -SGRYSCVA---VSAVGEDRQDVVLQV-------HMPPSIL---GEELNVSVVANESVAL 808

Query: 261  ECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKA-LRITNVSEEDSGEYFCLASNKMGSI 319
            EC +  +P P ++W+K G  L        + +KA L++      D+G Y C A N+ G  
Sbjct: 809  ECQSHAMPPPVLSWWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGHS 868

Query: 320  RHTISVRVKAAPYW-LDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPN- 377
                ++ V  AP + L E   L +  G   RL C   G P P + W  +G+PL       
Sbjct: 869  EKHYNLNVWVAPVFPLRESHTLTVREGHPTRLSCECRGVPFPKISWRKDGQPLPGEGAGL 928

Query: 378  PNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRN--QLIR 435
             +    G  +     Q++    Y C  SN  G    +  + V  VPP++  PR     + 
Sbjct: 929  QHVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEV-HVPPQIAGPREPPTQVS 987

Query: 436  VILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTC 495
            V+      L+C   G P PT+ W ++GQ    + G     +  SL ++  +    G Y+C
Sbjct: 988  VVQDGVATLECNATGKPPPTVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSC 1047

Query: 496  VATNILGKAENQVRLEVKDPTRIYRMPE---DQVARRGTTVQLECRVKHDPSLKLTVSWL 552
            VA N+ G+AE +  L V  P  +    +   +  A   + + L C     P     + W 
Sbjct: 1048 VAENLAGRAERKFELSVLVPPELIGDLDPLTNITAALHSPLTLLCEAMGIP--PPAIRWF 1105

Query: 553  KDDEPLYIGNRMKKEDDSLTIFG-------VAERDQGSYTCVASTE 591
            + +EP+  G     ED  L   G         E+D G Y+C+AS E
Sbjct: 1106 RGEEPVSPG-----EDTYLLAGGWMLKMTQTQEQDSGLYSCLASNE 1146



 Score =  135 bits (341), Expect = 8e-32
 Identities = 125/495 (25%), Positives = 203/495 (41%), Gaps = 31/495 (6%)

Query: 34  PPTITKQSAKDHIVDPR-DNILIECEAKGNPAPSFHWTRNSRFFNIAKDPR-----VSMR 87
           PP+I +   K ++      ++ +EC+A G P P   W ++++   +          +   
Sbjct: 16  PPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWG 75

Query: 88  RRSGTLVIDF-RSGGRPEEYEGE---YQCFARNKFGTALSNRIRLQVSKSPLWPKENLDP 143
           +  G  ++D  +S   P   EG+   Y C A N+ GTA  +   L ++   +        
Sbjct: 76  QVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGAGAAQE 135

Query: 144 VVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQT 203
           V+   GA + LQC    G+P+P + W       +     +    +G +          + 
Sbjct: 136 VLGLAGADVELQCWTS-GVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEG 194

Query: 204 DYSCNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECI 263
            Y C A   F+   QQ   F L+V          P  ++         V+    + L C 
Sbjct: 195 RYQCVA---FSPAGQQARDFQLRV--------HAPPTIWGSNETGEVAVMEDHLVQLLCE 243

Query: 264 ASGVPTPDIAWYKKGGDLP-SDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHT 322
           A GVPTP+I W+K G  LP S K  +    + L++      D+G Y C ASN +G+    
Sbjct: 244 ARGVPTPNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKA 303

Query: 323 ISVRVKAAPYWLD---EPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPN 379
             + V   P        P  +    G    L C A G+P PT+ W   G P+  A  N +
Sbjct: 304 TRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEGLPV--AESNES 361

Query: 380 R-EVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQ-LIRVI 437
           R E  G  +       +S  +Y C  S+  G  +    V V  VPP++L       +  I
Sbjct: 362 RLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEV-QVPPQLLVAEGLGQVTTI 420

Query: 438 LYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVA 497
           +     L C   GSP+PT++W +NG+ +    G     +  +L I  +  +  G++ C A
Sbjct: 421 VGQPLELPCQASGSPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQA 480

Query: 498 TNILGKAENQVRLEV 512
           TN  G A  +V + V
Sbjct: 481 TNEAGTAGAEVEVSV 495



 Score =  134 bits (338), Expect = 2e-31
 Identities = 154/610 (25%), Positives = 246/610 (40%), Gaps = 55/610 (9%)

Query: 29   MDLTQPPTITKQSAKDHI-VDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMR 87
            +++  PP+I  +  ++ I V       + C   G+P P   W ++ R         +S  
Sbjct: 1156 VEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHISP- 1214

Query: 88   RRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPL---WPKENLDP- 143
               G L+   ++        G Y C A N  G   +   +L V  +P      +++ D  
Sbjct: 1215 --DGVLLQVLQAN---LSSAGHYSCIAANAVGEK-TKHFQLSVLLAPTILGGAEDSADEE 1268

Query: 144  VVVQEGAPLTLQCNPPPGLPSPVIFWMSSSME-PITQDKRVSQGHNGDLYFSNVMLQDMQ 202
            V V    P++L C      PSP I WM        +++ ++  G +G L   N   +D  
Sbjct: 1269 VTVTVNNPISLICEAL-AFPSPNITWMKDGAPFEASRNIQLLPGTHG-LQILNAQKEDAG 1326

Query: 203  TDYSCNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLEC 262
              Y+C         ++    + ++VL    +++  P          +++      L LEC
Sbjct: 1327 -QYTCVVTNELGEAVKN---YHVEVLIPPSISKDDPLAEVGVKEVKTKV---NSTLTLEC 1379

Query: 263  IASGVPTPDIAWYKKGGDL-PSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRH 321
             +  VP P I WYK G  + PS + +     + L+I      DSG Y C+A+N  G    
Sbjct: 1380 ESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQ 1439

Query: 322  TISVRVKAAPYWLD----EPKNLILAPGEDGR----------------LVCRANGNPKPT 361
              +V ++  P +           IL+  E+ R                L C  N  P P 
Sbjct: 1440 DFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPD 1499

Query: 362  VQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLD 421
            + W    +PL SA    +    G  +     +  +   Y C  SNE G    +  + VL 
Sbjct: 1500 LTWYREDQPL-SAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVGEDWLHYELLVL- 1557

Query: 422  VPPRMLSPRNQLIRVILYNRTR---LDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENG 478
             PP +L    +L+  +  N +    L CP  G+P+PT+ W +NG   +       V E+G
Sbjct: 1558 TPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFS-PSPRLQVLEDG 1616

Query: 479  S-LEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQV-ARRGTTVQLE 536
              L++      D   Y CVA N  G AE    L V+ P RI  +  +QV A   ++V L 
Sbjct: 1617 QVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQVPPRIAGLDLEQVTAILNSSVSLP 1676

Query: 537  CRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTI-FGVAE-RDQGSYTCVASTELDQ 594
            C V   P+ ++T  W KD + L +G  +     + T+  G A   D G YTC A     +
Sbjct: 1677 CDVHAHPNPEVT--WYKDSQALSLGEEVFLLPGTHTLQLGRARLSDSGMYTCEALNAAGR 1734

Query: 595  DLAKAYLTVL 604
            D     L+VL
Sbjct: 1735 DQKLVQLSVL 1744



 Score =  132 bits (333), Expect = 7e-31
 Identities = 147/571 (25%), Positives = 220/571 (38%), Gaps = 77/571 (13%)

Query: 55  IECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFA 114
           + C+A G+P P+  W +N R     +   V +  +  TL ID        ++ G + C A
Sbjct: 427 LPCQASGSPVPTIQWLQNGR--PAEELAGVQVASQGTTLHIDHVE----LDHSGLFACQA 480

Query: 115 RNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQ------EGAPLTLQCNPP--------- 159
            N+ GTA +    ++VS    W    L+  + Q        +     C+PP         
Sbjct: 481 TNEAGTAGAE---VEVSVHGEWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGAHP 537

Query: 160 -----PGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFT 214
                 G  SP   W   +  P      V+      L    V L+D +  Y+C A     
Sbjct: 538 KPPLVEGWCSPGSLWGEPTGIP------VAYSLPPPLQIEKVDLRD-EGIYTCAAT---N 587

Query: 215 HTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAW 274
              + K    LKVL    +          +    ++ VL    + LEC+ASGVP PD++W
Sbjct: 588 LAGESKREVALKVLVPPNI----------EPGPVNKAVLENASVTLECLASGVPPPDVSW 637

Query: 275 YKKGGDLPSDKAKFENFN-KALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYW 333
           +K    + S      + + + LRI      D+G Y C+ASN  GS      +RV      
Sbjct: 638 FKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRYGLRVNV---- 693

Query: 334 LDEPKNLILAPGEDG--------RLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREV--A 383
              P  + L P   G        RL C A G P PT+ W+ +G P+  A   P  +V   
Sbjct: 694 ---PPRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPA-GTPGLQVFPG 749

Query: 384 GDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTR 443
           G  +     + S    Y C   +  G    +  + V  +PP +L      + V+      
Sbjct: 750 GRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQV-HMPPSILGEELN-VSVVANESVA 807

Query: 444 LDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGK 503
           L+C     P P L W+K+G+      G +   +   L++      D G YTC A N  G 
Sbjct: 808 LECQSHAMPPPVLSWWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGH 867

Query: 504 AENQVRLEV-KDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPL---Y 559
           +E    L V   P    R       R G   +L C  +  P  K  +SW KD +PL    
Sbjct: 868 SEKHYNLNVWVAPVFPLRESHTLTVREGHPTRLSCECRGVPFPK--ISWRKDGQPLPGEG 925

Query: 560 IGNRMKKEDDSLTIFGVAE-RDQGSYTCVAS 589
            G +       L   G A+   +G+YTC  S
Sbjct: 926 AGLQHVSAVGRLLYLGQAQLAQEGTYTCECS 956



 Score =  122 bits (306), Expect = 1e-27
 Identities = 103/378 (27%), Positives = 159/378 (42%), Gaps = 29/378 (7%)

Query: 238 PSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKK-------------GGDLPSD 284
           P  +   G  ++   + G  L LEC A+G P P+I W K              G DL   
Sbjct: 16  PPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWG 75

Query: 285 KA---KFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDE--PKN 339
           +    +  +  ++L    + E DSG Y C A N+ G+ +    + V   P  L     + 
Sbjct: 76  QVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGAGAAQE 135

Query: 340 LILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAV 399
           ++   G D  L C  +G P P V+W  + +P+    P+   +  G  +    + +     
Sbjct: 136 VLGLAGADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGR 195

Query: 400 YQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWF 459
           YQC   +  G    +  + V   P    S     + V+  +  +L C   G P P + WF
Sbjct: 196 YQCVAFSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWF 255

Query: 460 KNGQGSNLDGGNYHVYENGSLEIKMIRKE--DQGIYTCVATNILGKAENQVRLEVKDPTR 517
           K+G  + L      VY  G  ++++ R +  D G+YTC A+N +G AE   RL+V  P  
Sbjct: 256 KDG--ALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPT 313

Query: 518 IY---RMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDS--LT 572
           I      P    A  G  V LEC  +  PS   T+SW  +  P+   N  + E D   L 
Sbjct: 314 IEGAGGRPYVVKAVAGRPVALECVARGHPS--PTLSWHHEGLPVAESNESRLETDGSVLR 371

Query: 573 IFGVAERDQGSYTCVAST 590
           +    E   G Y+CVAS+
Sbjct: 372 LESPGEASSGLYSCVASS 389



 Score =  120 bits (302), Expect = 3e-27
 Identities = 107/413 (25%), Positives = 180/413 (43%), Gaps = 34/413 (8%)

Query: 16   LCLL--SLGGAIEIPMDLTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNS 73
            LC+   S G A+     + Q P + +    D       +  + C+A+G+P P+  W ++ 
Sbjct: 2734 LCIAKNSAGSAMGKTRLVVQVPPVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDG 2793

Query: 74   RFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKS 133
            +  + A+       + SG L++    G    +  G Y C A N  G A   R+ L +   
Sbjct: 2794 QPVSGAEGKFTI--QPSGELLVKNLEG----QDAGTYTCTAENAVGRA-RRRVHLTILVL 2846

Query: 134  PLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYF 193
            P++     D  + + G  L L+C    G P+P I W  +   P+T+   VS+   G    
Sbjct: 2847 PVFTTLPGDRSL-RLGDRLWLRC-AARGSPTPRIGWTVND-RPVTEG--VSEQDGGSTLQ 2901

Query: 194  SNVMLQDMQTDYSCNA--RFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQM 251
               + ++    Y C A  R   T  +   +     VL               QG A S +
Sbjct: 2902 RAAVSREDSGTYVCWAENRVGRTQAVSFVHVKEAPVL---------------QGEAFSYL 2946

Query: 252  VLR-GMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFC 310
            V   G  + L+C+  G P PDI W K G  L     + +  N +L I     +D+G Y C
Sbjct: 2947 VEPVGGSIQLDCVVRGDPVPDIHWIKDGLPLRGSHLRHQLQNGSLTIRRTERDDAGRYQC 3006

Query: 311  LASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEP 370
            LA N+MG  +  + + +++AP +  EP+++ +  G+D  L C+A G P PT++W+  G+P
Sbjct: 3007 LAENEMGVAKKVVILVLQSAPVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQP 3066

Query: 371  LQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVP 423
            L+++     R +   ++   + +      Y C   N  G   A AF+ V   P
Sbjct: 3067 LRAS--RRLRTLPDGSLWLENVETGDAGTYDCVAHNLLGSATARAFLVVRGEP 3117



 Score =  112 bits (280), Expect = 1e-24
 Identities = 126/483 (26%), Positives = 198/483 (40%), Gaps = 44/483 (9%)

Query: 149 GAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNV----MLQDMQTD 204
           G  LTL+C+   G P P I W+  +   +        G+  DL +  V    +L + Q+ 
Sbjct: 33  GQSLTLECDAN-GFPVPEIVWLKDAQ--LVGVPLGWAGYGWDLGWGQVGGHRLLDEGQS- 88

Query: 205 YSCNARFHFTHTIQQKNP--FTLKVLTTRGVAER-------TPSFMYPQGTASSQMVLRG 255
                  HF   IQ+ +   ++ +     G A+R       TP  +   G A   + L G
Sbjct: 89  ------LHFPR-IQEGDSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGAGAAQEVLGLAG 141

Query: 256 MDLLLECIASGVPTPDIAWYK-KGGDLPSDK-AKFENFNKALRITNVSEEDSGEYFCLAS 313
            D+ L+C  SGVPTP + W K +   LP     + +   + LRIT     D G Y C+A 
Sbjct: 142 ADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAF 201

Query: 314 NKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDG--RLVCRANGNPKPTVQWMVNGEPL 371
           +  G       +RV A P      +   +A  ED   +L+C A G P P + W  +G  L
Sbjct: 202 SPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALL 261

Query: 372 QSAPPNPNREV---AGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRM-- 426
               P   + V    G  +     Q S   VY C  SN  G       + V  VPP +  
Sbjct: 262 ----PTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVY-VPPTIEG 316

Query: 427 LSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIR 486
              R  +++ +      L+C   G P PTL W   G        +    +   L ++   
Sbjct: 317 AGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNESRLETDGSVLRLESPG 376

Query: 487 KEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPE-DQVAR-RGTTVQLECRVKHDPS 544
           +   G+Y+CVA++  G+A  Q  +EV+ P ++       QV    G  ++L C+    P 
Sbjct: 377 EASSGLYSCVASSPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSP- 435

Query: 545 LKLTVSWLKDDEPL--YIGNRMKKEDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLT 602
              T+ WL++  P     G ++  +  +L I  V     G + C A+ E     A+  ++
Sbjct: 436 -VPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEVEVS 494

Query: 603 VLG 605
           V G
Sbjct: 495 VHG 497


>gi|118572606 hemicentin 1 [Homo sapiens]
          Length = 5635

 Score =  182 bits (461), Expect = 1e-45
 Identities = 159/593 (26%), Positives = 259/593 (43%), Gaps = 60/593 (10%)

Query: 26   EIPMDLTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRN------SRFFNIA 79
            +I +D+  PP   ++ A D  ++   N+ + C  +G P P+  W R       SR F+++
Sbjct: 784  KITLDVGSPPVFIQEPA-DVSMEIGSNVTLPCYVQGYPEPTIKWRRLDNMPIFSRPFSVS 842

Query: 80   KDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKE 139
                +S  R     +++  +  +     G Y C A N+FG  + +   + V+   + P  
Sbjct: 843  S---ISQLRTGALFILNLWASDK-----GTYICEAENQFGK-IQSETTVTVT-GLVAPLI 892

Query: 140  NLDPVV--VQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVM 197
             + P V  V EG  LTL C    G P P   W+ +S   + Q+  ++   +G L+   V 
Sbjct: 893  GISPSVANVIEGQQLTLPCTLLAGNPIPERRWIKNSAM-LLQNPYITVRSDGSLHIERVQ 951

Query: 198  LQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMD 257
            LQD   +Y+C A           N       TT  V    P+  + Q   S+   + G+ 
Sbjct: 952  LQD-GGEYTCVA----------SNVAGTNNKTTSVVVHVLPTIQHGQQILST---IEGIP 997

Query: 258  LLLECIASGVPTPDIAWYKKGGDLPSDKAKFE-NFNKALRITNVSEEDSGEYFCLASNKM 316
            + L C ASG P P + W KKG  + +  AKF    + +L + +   E+SGEY C A+N  
Sbjct: 998  VTLPCKASGNPKPSVIWSKKGELISTSSAKFSAGADGSLYVVSPGGEESGEYVCTATNTA 1057

Query: 317  GSIRHTISVRVKAAPYWL--------DEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNG 368
            G  +  + + V   P           D+P  + +  GE+  L C     P P + W    
Sbjct: 1058 GYAKRKVQLTVYVRPRVFGDQRGLSQDKPVEISVLAGEEVTLPCEVKSLPPPIITWAKET 1117

Query: 369  EPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLS 428
            + +    P      +G   I  +T+ S   +Y C  +N  G +     ++V  VPP++  
Sbjct: 1118 QLISPFSPRHTFLPSGSMKI-TETRTSDSGMYLCVATNIAGNVTQAVKLNV-HVPPKIQR 1175

Query: 429  PRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKE 488
                L +V +  R  + C   G+P+P + W K G    +DG ++    +G+L I      
Sbjct: 1176 GPKHL-KVQVGQRVDIPCNAQGTPLPVITWSKGGSTMLVDGEHHVSNPDGTLSIDQATPS 1234

Query: 489  DQGIYTCVATNILGKAENQVRLEVKDPTRIYRMP-------EDQVARRGTTVQLECRVKH 541
            D GIYTCVATNI G  E ++ L V++P  +  +        +++VA +   ++  C  K 
Sbjct: 1235 DAGIYTCVATNIAGTDETEITLHVQEPPTVEDLEPPYNTTFQERVANQ--RIEFPCPAKG 1292

Query: 542  DPSLKLTVSWLKDDEPL---YIGNRMKKEDDSLTIFGVAERDQGSYTCVASTE 591
             P  K T+ WL +   L     G  + ++   L I  V   D G Y CVA  E
Sbjct: 1293 TP--KPTIKWLHNGRELTGREPGISILEDGTLLVIASVTPYDNGEYICVAVNE 1343



 Score =  181 bits (458), Expect = 2e-45
 Identities = 165/591 (27%), Positives = 248/591 (41%), Gaps = 40/591 (6%)

Query: 27   IPMDLTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSM 86
            + + + +PP I  Q ++ H++   + IL+ CEA G P+P   W +     N+    R   
Sbjct: 3980 VTLHVHEPPVIQPQPSELHVI-LNNPILLPCEATGTPSPFITWQKEG--INVNTSGRNHA 4036

Query: 87   RRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVV 146
               SG L I         E  G Y C A+N  GTAL  +I+L V   P+    +L   V+
Sbjct: 4037 VLPSGGLQIS----RAVREDAGTYMCVAQNPAGTALG-KIKLNVQVPPVI-SPHLKEYVI 4090

Query: 147  QEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYS 206
                P+TL C    GLP P I W       I +  R     +G L  + V   D    Y+
Sbjct: 4091 AVDKPITLSCEAD-GLPPPDITWHKDG-RAIVESIRQRVLSSGSLQIAFVQPGDAG-HYT 4147

Query: 207  CNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASG 266
            C A           N       +T+      P     + T     V      +L C+A G
Sbjct: 4148 CMAA----------NVAGSSSTSTKLTVHVPPRI---RSTEGHYTVNENSQAILPCVADG 4194

Query: 267  VPTPDIAWYKKGGDLPSDKAKF--ENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTIS 324
            +PTP I W K    L +   K+  E + + + + NV  EDSG Y C+A+N  G   HT+S
Sbjct: 4195 IPTPAINWKKDNVLLANLLGKYTAEPYGELI-LENVVLEDSGFYTCVANNAAGEDTHTVS 4253

Query: 325  VRVKAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGE--PLQSAPPNPNREV 382
            + V   P + + P ++ L  GE  RL C+A G P P + W  N    P      N + E+
Sbjct: 4254 LTVHVLPTFTELPGDVSLNKGEQLRLSCKATGIPLPKLTWTFNNNIIPAHFDSVNGHSEL 4313

Query: 383  AGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRT 442
              + +   D+       Y C   N  G++ A  FV V + P       +  I  +  N  
Sbjct: 4314 VIERVSKEDS-----GTYVCTAENSVGFVKAIGFVYVKEPPVFKGDYPSNWIEPLGGNAI 4368

Query: 443  RLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILG 502
             L+C   G P PT++W + G    +         NGSL I     ED G YTCVATN  G
Sbjct: 4369 -LNCEVKGDPTPTIQWNRKGVDIEISH-RIRQLGNGSLAIYGTVNEDAGDYTCVATNEAG 4426

Query: 503  KAENQVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGN 562
              E  + L ++ P  I   P + V   G  + L C+   +P  + T++W +    +   +
Sbjct: 4427 VVERSMSLTLQSPPIITLEPVETVINAGGKIILNCQATGEP--QPTITWSRQGHSISWDD 4484

Query: 563  RMK-KEDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTVLGNCPCSPW 612
            R+    ++SL I    + D   + CVA   +   L +  + V  +   S W
Sbjct: 4485 RVNVLSNNSLYIADAQKEDTSEFECVARNLMGSVLVRVPVIVQVHGGFSQW 4535



 Score =  172 bits (436), Expect = 8e-43
 Identities = 156/577 (27%), Positives = 243/577 (42%), Gaps = 42/577 (7%)

Query: 26   EIPMDLTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVS 85
            E  + +  PPTI      + +V     + ++C A G P PS  W ++ +  N A+    +
Sbjct: 1817 EFEVTVHVPPTIKSSGLSERVVVKYKPVALQCIANGIPNPSITWLKDDQPVNTAQG---N 1873

Query: 86   MRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSP-LWPKENLDPV 144
            ++ +S   V+         E  G Y C A N  G      I+L V + P L     +   
Sbjct: 1874 LKIQSSGRVLQIAK--TLLEDAGRYTCVATNAAGET-QQHIQLHVHEPPSLEDAGKMLNE 1930

Query: 145  VVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTD 204
             V    P+ L+C    G P PVI W         +D R+  G     + +   + D+++ 
Sbjct: 1931 TVLVSNPVQLECKAA-GNPVPVITWY--------KDNRLLSGSTSMTFLNRGQIIDIESA 1981

Query: 205  YSCNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIA 264
               +A  +    I       L       VA   PS     G+ +   V+    + LEC A
Sbjct: 1982 QISDAGIYKCVAINSAGATELFYSLQVHVA---PSI---SGSNNMVAVVVNNPVRLECEA 2035

Query: 265  SGVPTPDIAWYKKGGDLPSDKAKFENFN--KALRITNVSEEDSGEYFCLASNKMGSIRHT 322
             G+P P + W K G  + S     +  +  + L +T+    D+G Y C+A N  G  +  
Sbjct: 2036 RGIPAPSLTWLKDGSPVSSFSNGLQVLSGGRILALTSAQISDTGRYTCVAVNAAGEKQRD 2095

Query: 323  ISVRVKAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPP---NPN 379
            I +RV   P  + E +N+ +   +   L+C+++  P PT+ W+ +G PL   P    + N
Sbjct: 2096 IDLRVYVPPNIMGEEQNVSVLISQAVELLCQSDAIPPPTLTWLKDGHPLLKKPGLSISEN 2155

Query: 380  REVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRM-LSPRNQLIRVIL 438
            R V    +   D Q+     Y C  +N  G    N  V++  VPP +  S     + VI 
Sbjct: 2156 RSV----LKIEDAQVQDTGRYTCEATNVAGKTEKNYNVNIW-VPPNIGGSDELTQLTVIE 2210

Query: 439  YNRTRLDCPFFGSPIPTLRWFKNGQGSNLDG-GNYHVYENG-SLEIKMIRKEDQGIYTCV 496
             N   L C   G P P L W K G     D  G   +   G  L+I +  K D  +Y+CV
Sbjct: 2211 GNLISLLCESSGIPPPNLIWKKKGSPVLTDSMGRVRILSGGRQLQISIAEKSDAALYSCV 2270

Query: 497  ATNILGKAENQVRLEV---KDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLK 553
            A+N+ G A+ +  L+V      T     P + +  RG ++ LEC V+  P    TV+W+K
Sbjct: 2271 ASNVAGTAKKEYNLQVYIRPTITNSGSHPTEIIVTRGKSISLECEVQGIP--PPTVTWMK 2328

Query: 554  DDEPLY--IGNRMKKEDDSLTIFGVAERDQGSYTCVA 588
            D  PL    G  +  E   L +  +   D G Y CVA
Sbjct: 2329 DGHPLIKAKGVEILDEGHILQLKNIHVSDTGRYVCVA 2365



 Score =  170 bits (431), Expect = 3e-42
 Identities = 152/581 (26%), Positives = 244/581 (41%), Gaps = 54/581 (9%)

Query: 29   MDLTQPPTITKQSAKDHI-VDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMR 87
            +D+  PPTI   +  + + V    ++ +EC+ KG P P  HW ++ +   +  DP V + 
Sbjct: 1446 IDVLVPPTIIGTNFPNEVSVVLNRDVALECQVKGTPFPDIHWFKDGKPLFLG-DPNVELL 1504

Query: 88   RRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENL-DPVVV 146
             R    V+  ++  R +  +G YQC   N  G    + I+L +   P     N+   + V
Sbjct: 1505 DRG--QVLHLKNARRND--KGRYQCTVSNAAGKQAKD-IKLTIYIPPSIKGGNVTTDISV 1559

Query: 147  QEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYS 206
               + + L+C    GLP P I W       ++  + +       L+     + D  T Y+
Sbjct: 1560 LINSLIKLECE-TRGLPMPAITWYKDGQPIMSSSQALYIDKGQYLHIPRAQVSDSAT-YT 1617

Query: 207  CNARFHFTHTIQQKNPFTLKVLTTRGVAERT--------PSFMYPQGTASSQMVLRGMDL 258
            C+                  V    G AE++        P       T  ++ V+    L
Sbjct: 1618 CH------------------VANVAGTAEKSFHVDVYVPPMIEGNLATPLNKQVVIAHSL 1659

Query: 259  LLECIASGVPTPDIAWYKKGGDL-PSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMG 317
             LEC A+G P+P + W K G  +  +D  + E   K L I +  E D G+Y C+A++  G
Sbjct: 1660 TLECKAAGNPSPILTWLKDGVPVKANDNIRIEAGGKKLEIMSAQEIDRGQYICVATSVAG 1719

Query: 318  --SIRHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAP 375
               I++ + V V  A    DE    I+       L C   G+P PT+ W+ +G+ L    
Sbjct: 1720 EKEIKYEVDVLVPPAIEGGDETSYFIVMVNNLLELDCHVTGSPPPTIMWLKDGQ-LIDER 1778

Query: 376  PNPNREVAGDTIIFRDTQISSRAVYQC---NTSNEHGYLLANAFVSVLDVPPRMLSPRNQ 432
                  + G  ++    Q+S+  +Y+C   NT+ +H       F   + VPP + S    
Sbjct: 1779 DGFKILLNGRKLVIAQAQVSNTGLYRCMAANTAGDH----KKEFEVTVHVPPTIKSSGLS 1834

Query: 433  LIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGS-LEIKMIRKEDQG 491
               V+ Y    L C   G P P++ W K+ Q  N   GN  +  +G  L+I     ED G
Sbjct: 1835 ERVVVKYKPVALQCIANGIPNPSITWLKDDQPVNTAQGNLKIQSSGRVLQIAKTLLEDAG 1894

Query: 492  IYTCVATNILGKAENQVRLEVKDPTRIYRMPE--DQVARRGTTVQLECRVKHDPSLKLTV 549
             YTCVATN  G+ +  ++L V +P  +    +  ++       VQLEC+   +P   +T 
Sbjct: 1895 RYTCVATNAAGETQQHIQLHVHEPPSLEDAGKMLNETVLVSNPVQLECKAAGNPVPVIT- 1953

Query: 550  SWLKDDEPLYIGNRMK--KEDDSLTIFGVAERDQGSYTCVA 588
             W KD+  L     M        + I      D G Y CVA
Sbjct: 1954 -WYKDNRLLSGSTSMTFLNRGQIIDIESAQISDAGIYKCVA 1993



 Score =  163 bits (412), Expect = 5e-40
 Identities = 154/594 (25%), Positives = 248/594 (41%), Gaps = 42/594 (7%)

Query: 27   IPMDLTQPPTITKQSAKDHI-VDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVS 85
            + +++  PP I  Q    H+ V     + I C A+G P P   W++      +  +  VS
Sbjct: 1163 VKLNVHVPPKI--QRGPKHLKVQVGQRVDIPCNAQGTPLPVITWSKGGSTMLVDGEHHVS 1220

Query: 86   MRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDP-- 143
                 GTL ID  +   P +  G Y C A N  GT     I L V + P    E+L+P  
Sbjct: 1221 --NPDGTLSIDQAT---PSD-AGIYTCVATNIAGTD-ETEITLHVQEPPT--VEDLEPPY 1271

Query: 144  -VVVQEGAP---LTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQ 199
                QE      +   C P  G P P I W+ +  E   ++  +S   +G L     +  
Sbjct: 1272 NTTFQERVANQRIEFPC-PAKGTPKPTIKWLHNGRELTGREPGISILEDGTLLVIASVTP 1330

Query: 200  DMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLL 259
                +Y C A  +   T ++K  + LKV          P  +  +   ++  VL      
Sbjct: 1331 YDNGEYICVA-VNEAGTTERK--YNLKV--------HVPPVIKDKEQVTNVSVLLNQLTN 1379

Query: 260  LECIASGVPTPDIAWYKKGGDLP-SDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGS 318
            L C   G P+P I WYK    +  S   +  N  K L++   + ED+G Y C A N  G+
Sbjct: 1380 LFCEVEGTPSPIIMWYKDNVQVTESSTIQTVNNGKILKLFRATPEDAGRYSCKAINIAGT 1439

Query: 319  IRHTISVRVKAAPYWLDE--PKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPP 376
             +   ++ V   P  +    P  + +    D  L C+  G P P + W  +G+PL    P
Sbjct: 1440 SQKYFNIDVLVPPTIIGTNFPNEVSVVLNRDVALECQVKGTPFPDIHWFKDGKPLFLGDP 1499

Query: 377  NPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQL-IR 435
            N      G  +  ++ + + +  YQC  SN  G    +  +++  +PP +        I 
Sbjct: 1500 NVELLDRGQVLHLKNARRNDKGRYQCTVSNAAGKQAKDIKLTIY-IPPSIKGGNVTTDIS 1558

Query: 436  VILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTC 495
            V++ +  +L+C   G P+P + W+K+GQ         ++ +   L I   +  D   YTC
Sbjct: 1559 VLINSLIKLECETRGLPMPAITWYKDGQPIMSSSQALYIDKGQYLHIPRAQVSDSATYTC 1618

Query: 496  VATNILGKAENQVRLEVKDPTRI---YRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWL 552
               N+ G AE    ++V  P  I      P ++      ++ LEC+   +PS  LT  WL
Sbjct: 1619 HVANVAGTAEKSFHVDVYVPPMIEGNLATPLNKQVVIAHSLTLECKAAGNPSPILT--WL 1676

Query: 553  KDDEPLYIGNRMKKE--DDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTVL 604
            KD  P+   + ++ E     L I    E D+G Y CVA++   +   K  + VL
Sbjct: 1677 KDGVPVKANDNIRIEAGGKKLEIMSAQEIDRGQYICVATSVAGEKEIKYEVDVL 1730



 Score =  159 bits (402), Expect = 7e-39
 Identities = 151/570 (26%), Positives = 237/570 (41%), Gaps = 41/570 (7%)

Query: 29   MDLTQ--PPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSM 86
            +DLT   PP+I  +   D +V      +I C A G P PS HWT+N     I   PR   
Sbjct: 3889 VDLTVQVPPSIADEPT-DFLVTKHAPAVITCTASGVPFPSIHWTKN----GIRLLPRGDG 3943

Query: 87   RRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVV 146
             R   +  I+  +      + G Y C ARN  G+A    + L V + P+   +  +  V+
Sbjct: 3944 YRILSSGAIEILA--TQLNHAGRYTCVARNAAGSA-HRHVTLHVHEPPVIQPQPSELHVI 4000

Query: 147  QEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYS 206
                P+ L C    G PSP I W    +   T  +  +   +G L  S  + +D  T Y 
Sbjct: 4001 LNN-PILLPCE-ATGTPSPFITWQKEGINVNTSGRNHAVLPSGGLQISRAVREDAGT-YM 4057

Query: 207  CNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASG 266
            C A          +NP     L    +  + P  + P       ++     + L C A G
Sbjct: 4058 CVA----------QNP-AGTALGKIKLNVQVPPVISPH--LKEYVIAVDKPITLSCEADG 4104

Query: 267  VPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVR 326
            +P PDI W+K G  +     +    + +L+I  V   D+G Y C+A+N  GS   +  + 
Sbjct: 4105 LPPPDITWHKDGRAIVESIRQRVLSSGSLQIAFVQPGDAGHYTCMAANVAGSSSTSTKLT 4164

Query: 327  VKAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDT 386
            V   P       +  +       L C A+G P P + W  +   L +       E  G+ 
Sbjct: 4165 VHVPPRIRSTEGHYTVNENSQAILPCVADGIPTPAINWKKDNVLLANLLGKYTAEPYGE- 4223

Query: 387  IIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDC 446
            +I  +  +     Y C  +N  G       ++V  +P     P +  + +    + RL C
Sbjct: 4224 LILENVVLEDSGFYTCVANNAAGEDTHTVSLTVHVLPTFTELPGD--VSLNKGEQLRLSC 4281

Query: 447  PFFGSPIPTLRWFKNGQ--GSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKA 504
               G P+P L W  N     ++ D  N H      L I+ + KED G Y C A N +G  
Sbjct: 4282 KATGIPLPKLTWTFNNNIIPAHFDSVNGH----SELVIERVSKEDSGTYVCTAENSVGFV 4337

Query: 505  ENQVRLEVKDPTRIYR--MPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGN 562
            +    + VK+P  +++   P + +   G    L C VK DP+   T+ W +    + I +
Sbjct: 4338 KAIGFVYVKEPP-VFKGDYPSNWIEPLGGNAILNCEVKGDPT--PTIQWNRKGVDIEISH 4394

Query: 563  RMKK-EDDSLTIFGVAERDQGSYTCVASTE 591
            R+++  + SL I+G    D G YTCVA+ E
Sbjct: 4395 RIRQLGNGSLAIYGTVNEDAGDYTCVATNE 4424



 Score =  155 bits (393), Expect = 8e-38
 Identities = 148/593 (24%), Positives = 247/593 (41%), Gaps = 44/593 (7%)

Query: 23   GAIEIPMDLTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDP 82
            G  +   D+++PP +  Q   +  V P +  ++ C        +  W RN R   +A+  
Sbjct: 508  GRAQTFFDVSEPPPVI-QVPNNVTVTPGERAVLTCLIISAVDYNLTWQRNDRDVRLAEPA 566

Query: 83   RVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSP---LWPKE 139
            R+   R    L ++ +S    +   GEY C   ++ G++ ++ + L V + P   + PK 
Sbjct: 567  RI---RTLANLSLELKSVKFNDA--GEYHCMVSSEGGSSAAS-VFLTVQEPPKVTVMPKN 620

Query: 140  NLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQ 199
                     G+ +++ C+   G P P I W  + M  I    R     +G L+  N   +
Sbjct: 621  QS----FTGGSEVSIMCSAT-GYPKPKIAWTVNDMF-IVGSHRYRMTSDGTLFIKNAAPK 674

Query: 200  DMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLL 259
            D    Y C A          K   TL+ +         P  M  Q   S  +V  G   +
Sbjct: 675  DAGI-YGCLAS---NSAGTDKQNSTLRYI-------EAPKLMVVQ---SELLVALGDITV 720

Query: 260  LECIASGVPTPDIAWYKKGGDL---PSDKAKFENFNKALRITNVSEEDSGEYFCLASNKM 316
            +EC  SG+P P + W+K  GDL   PS     +     L+I    + D+G+Y C+A N+ 
Sbjct: 721  MECKTSGIPPPQVKWFK--GDLELRPSTFLIIDPLLGLLKIQETQDLDAGDYTCVAINEA 778

Query: 317  GSIRHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQW-MVNGEPLQSAP 375
            G     I++ V + P ++ EP ++ +  G +  L C   G P+PT++W  ++  P+ S P
Sbjct: 779  GRATGKITLDVGSPPVFIQEPADVSMEIGSNVTLPCYVQGYPEPTIKWRRLDNMPIFSRP 838

Query: 376  PNPN--REVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQL 433
             + +   ++    +   +   S +  Y C   N+ G + +   V+V  +   ++     +
Sbjct: 839  FSVSSISQLRTGALFILNLWASDKGTYICEAENQFGKIQSETTVTVTGLVAPLIGISPSV 898

Query: 434  IRVILYNRTRLDCPFF-GSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGI 492
              VI   +  L C    G+PIP  RW KN     L      V  +GSL I+ ++ +D G 
Sbjct: 899  ANVIEGQQLTLPCTLLAGNPIPERRWIKN-SAMLLQNPYITVRSDGSLHIERVQLQDGGE 957

Query: 493  YTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWL 552
            YTCVA+N+ G       + V     I    +      G  V L C+   +P  K +V W 
Sbjct: 958  YTCVASNVAGTNNKTTSVVVHVLPTIQHGQQILSTIEGIPVTLPCKASGNP--KPSVIWS 1015

Query: 553  KDDEPLYIGNR--MKKEDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTV 603
            K  E +   +       D SL +      + G Y C A+        K  LTV
Sbjct: 1016 KKGELISTSSAKFSAGADGSLYVVSPGGEESGEYVCTATNTAGYAKRKVQLTV 1068



 Score =  153 bits (386), Expect = 5e-37
 Identities = 144/585 (24%), Positives = 238/585 (40%), Gaps = 37/585 (6%)

Query: 34   PPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTL 93
            PP++    +++  V   + I + CE  G P P   W +N +   +  +  +    R+  +
Sbjct: 2963 PPSVIGPKSENLTVVVNNFISLTCEVSGFPPPDLSWLKNEQPIKLNTNTLIVPGGRTLQI 3022

Query: 94   VIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPL---WPKENLDPVVVQEGA 150
            +    S G      GEY C A N+ G +   +  L V   P       E+L  V V+EG 
Sbjct: 3023 IRAKVSDG------GEYTCIAINQAGES-KKKFSLTVYVPPSIKDHDSESLSVVNVREGT 3075

Query: 151  PLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNAR 210
             ++L+C     +P PVI W  +    IT+   V    +G +             Y C A 
Sbjct: 3076 SVSLECESN-AVPPPVITWYKNG-RMITESTHVEILADGQMLHIKKAEVSDTGQYVCRA- 3132

Query: 211  FHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTP 270
                   +    F L V          PS   P+     + +     + L C A+G+P P
Sbjct: 3133 --INVAGRDDKNFHLNVYVP-------PSIEGPEREVIVETISN--PVTLTCDATGIPPP 3181

Query: 271  DIAW---YKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIR--HTISV 325
             IAW   +K+  +  S + +  +    L+I      DSG Y C+ASN  G  +  + +S+
Sbjct: 3182 TIAWLKNHKRIENSDSLEVRILSGGSKLQIARSQHSDSGNYTCIASNMEGKAQKYYFLSI 3241

Query: 326  RVKAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVA-G 384
            +V  +    + P ++ +  GE+  LVC ANG P P +QW+ +G+P+ S      R  A G
Sbjct: 3242 QVPPSVAGAEIPSDVSVLLGENVELVCNANGIPTPLIQWLKDGKPIASGETERIRVSANG 3301

Query: 385  DTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPP-RMLSPRNQLIRVILYNRTR 443
             T+       S    Y C  +N  G       ++V   P  R      + +  ++     
Sbjct: 3302 STLNIYGALTSDTGKYTCVATNPAGEEDRIFNLNVYVTPTIRGNKDEAEKLMTLVDTSIN 3361

Query: 444  LDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGK 503
            ++C   G+P P + W KNG    L      +     + I   +  D  +YTCVA+N  G 
Sbjct: 3362 IECRATGTPPPQINWLKNGLPLPLSSHIRLLAAGQVIRIVRAQVSDVAVYTCVASNRAGV 3421

Query: 504  AENQVRLEVKDPTRIYRM--PEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIG 561
                  L+V  P  +      E+    +G++  + C     P+   +++WL+D +PL + 
Sbjct: 3422 DNKHYNLQVFAPPNMDNSMGTEEITVLKGSSTSMACITDGTPA--PSMAWLRDGQPLGLD 3479

Query: 562  NRMKKEDDS--LTIFGVAERDQGSYTCVASTELDQDLAKAYLTVL 604
              +        L +      D G YTC+AS E  +      L VL
Sbjct: 3480 AHLTVSTHGMVLQLLKAETEDSGKYTCIASNEAGEVSKHFILKVL 3524



 Score =  152 bits (385), Expect = 7e-37
 Identities = 156/588 (26%), Positives = 238/588 (40%), Gaps = 46/588 (7%)

Query: 34   PPTITKQSAKDHIVDPRDN-ILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGT 92
            PP+I +   ++ IV+   N + + C+A G P P+  W +N +   I     + +R  SG 
Sbjct: 3150 PPSI-EGPEREVIVETISNPVTLTCDATGIPPPTIAWLKNHK--RIENSDSLEVRILSGG 3206

Query: 93   LVIDFRSGGRPEEYEGEYQCFARNKFGTALSNR-IRLQVSKSPLWPKENLDPVVVQEGAP 151
              +        +   G Y C A N  G A     + +QV  S    +   D V V  G  
Sbjct: 3207 SKLQIARSQHSDS--GNYTCIASNMEGKAQKYYFLSIQVPPSVAGAEIPSD-VSVLLGEN 3263

Query: 152  LTLQCNPPPGLPSPVIFWMSSSMEPIT--QDKRVSQGHNGDLYFSNVMLQDMQTDYSCNA 209
            + L CN   G+P+P+I W+    +PI   + +R+    NG        L      Y+C A
Sbjct: 3264 VELVCNAN-GIPTPLIQWLKDG-KPIASGETERIRVSANGSTLNIYGALTSDTGKYTCVA 3321

Query: 210  RFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPT 269
                    ++   F L V  T       P+    +  A   M L    + +EC A+G P 
Sbjct: 3322 T---NPAGEEDRIFNLNVYVT-------PTIRGNKDEAEKLMTLVDTSINIECRATGTPP 3371

Query: 270  PDIAWYKKGGDLP-SDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVK 328
            P I W K G  LP S   +     + +RI      D   Y C+ASN+ G      +++V 
Sbjct: 3372 PQINWLKNGLPLPLSSHIRLLAAGQVIRIVRAQVSDVAVYTCVASNRAGVDNKHYNLQVF 3431

Query: 329  AAPYWLDE--PKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDT 386
            A P   +    + + +  G    + C  +G P P++ W+ +G+PL     +      G  
Sbjct: 3432 APPNMDNSMGTEEITVLKGSSTSMACITDGTPAPSMAWLRDGQPL-GLDAHLTVSTHGMV 3490

Query: 387  IIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDC 446
            +     +      Y C  SNE G +  +  + VL+ P    S  ++ I VI+ N   L C
Sbjct: 3491 LQLLKAETEDSGKYTCIASNEAGEVSKHFILKVLEPPHINGSEEHEEISVIVNNPLELTC 3550

Query: 447  PFFGSPIPTLRWFKNG-------QGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATN 499
               G P P + W K+G       Q   L GG         L I   + ED G YTC+A++
Sbjct: 3551 IASGIPAPKMTWMKDGRPLPQTDQVQTLGGGEV-------LRISTAQVEDTGRYTCLASS 3603

Query: 500  ILGKAENQVRLEVKDPTRIYRM--PEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEP 557
              G  + +  + V  P  I     P D    R   V LEC  K D      ++WL++ E 
Sbjct: 3604 PAGDDDKEYLVRVHVPPNIAGTDEPRDITVLRNRQVTLEC--KSDAVPPPVITWLRNGER 3661

Query: 558  LYIGNRMK--KEDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTV 603
            L    R++       L I      D  +YTCVAS    +   +  LTV
Sbjct: 3662 LQATPRVRILSGGRYLQINNADLGDTANYTCVASNIAGKTTREFILTV 3709



 Score =  152 bits (384), Expect = 9e-37
 Identities = 153/576 (26%), Positives = 231/576 (40%), Gaps = 35/576 (6%)

Query: 34   PPTIT-KQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGT 92
            PP I      +D  V     + +EC++   P P   W RN     +   PRV +      
Sbjct: 3619 PPNIAGTDEPRDITVLRNRQVTLECKSDAVPPPVITWLRNGE--RLQATPRVRILSGGRY 3676

Query: 93   LVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPL 152
            L I+    G        Y C A N  G      I L V+  P   K     +V+      
Sbjct: 3677 LQINNADLGDT----ANYTCVASNIAGKTTREFI-LTVNVPPNI-KGGPQSLVILLNKST 3730

Query: 153  TLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFH 212
             L+C    G+P+P I W            R S   NG L+  +  + D    Y C A  +
Sbjct: 3731 VLECIAE-GVPTPRITWRKDGAVLAGNHARYSILENGFLHIQSAHVTDTGR-YLCMAT-N 3787

Query: 213  FTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDI 272
               T +++    + V          P  + P  T  +  V+  +   L C A+G+P P I
Sbjct: 3788 AAGTDRRRIDLQVHV----------PPSIAPGPT--NMTVIVNVQTTLACEATGIPKPSI 3835

Query: 273  AWYKKGGDLPSDKAKFEN---FNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKA 329
             W K G  L  D+ +       + +L I + S +D+  Y C  +N  G  + T+ + V+ 
Sbjct: 3836 NWRKNGHLLNVDQNQNSYRLLSSGSLVIISPSVDDTATYECTVTNGAGDDKRTVDLTVQV 3895

Query: 330  APYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPN-REVAGDTII 388
             P   DEP + ++       + C A+G P P++ W  NG  ++  P     R ++   I 
Sbjct: 3896 PPSIADEPTDFLVTKHAPAVITCTASGVPFPSIHWTKNG--IRLLPRGDGYRILSSGAIE 3953

Query: 389  FRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPF 448
               TQ++    Y C   N  G   A+  V++    P ++ P+   + VIL N   L C  
Sbjct: 3954 ILATQLNHAGRYTCVARNAAGS--AHRHVTLHVHEPPVIQPQPSELHVILNNPILLPCEA 4011

Query: 449  FGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQV 508
             G+P P + W K G   N  G N+ V  +G L+I    +ED G Y CVA N  G A  ++
Sbjct: 4012 TGTPSPFITWQKEGINVNTSGRNHAVLPSGGLQISRAVREDAGTYMCVAQNPAGTALGKI 4071

Query: 509  RLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMK-KE 567
            +L V+ P  I    ++ V      + L C     P   +T  W KD   +    R +   
Sbjct: 4072 KLNVQVPPVISPHLKEYVIAVDKPITLSCEADGLPPPDIT--WHKDGRAIVESIRQRVLS 4129

Query: 568  DDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTV 603
              SL I  V   D G YTC+A+           LTV
Sbjct: 4130 SGSLQIAFVQPGDAGHYTCMAANVAGSSSTSTKLTV 4165



 Score =  149 bits (377), Expect = 6e-36
 Identities = 163/614 (26%), Positives = 250/614 (40%), Gaps = 81/614 (13%)

Query: 35   PTITKQSAK--DHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGT 92
            PTIT   +   + IV    +I +ECE +G P P+  W ++      AK   +        
Sbjct: 2290 PTITNSGSHPTEIIVTRGKSISLECEVQGIPPPTVTWMKDGHPLIKAKGVEILDEGH--- 2346

Query: 93   LVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDP--VVVQEGA 150
             ++  ++    +   G Y C A N  G     +  L V   P     +  P  + V E  
Sbjct: 2347 -ILQLKNIHVSDT--GRYVCVAVNVAGMT-DKKYDLSVHAPPSIIGNHRSPENISVVEKN 2402

Query: 151  PLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQT------D 204
             ++L C    G+P P I W             VS  ++  +     ML+ MQT       
Sbjct: 2403 SVSLTCEAS-GIPLPSITWFKDGWP-------VSLSNSVRILSGGRMLRLMQTTMEDAGQ 2454

Query: 205  YSCNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIA 264
            Y+C  R       +++  F L VL         P  +  + T     V     + L C  
Sbjct: 2455 YTCVVR---NAAGEERKIFGLSVLV--------PPHIVGENTLEDVKVKEKQSVTLTCEV 2503

Query: 265  SGVPTPDIAWYKKGGDLPSDKAK-FENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTI 323
            +G P P+I W+K G  L  D+A    +  + L+ITNV    +G Y CLAS+  G    + 
Sbjct: 2504 TGNPVPEITWHKDGQPLQEDEAHHIISGGRFLQITNVQVPHTGRYTCLASSPAGHKSRSF 2563

Query: 324  SVRVKAAPYWLD-----EPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNP 378
            S+ V  +P          P+++ +       LVC A   P  T+ W  +G PL+S     
Sbjct: 2564 SLNVFVSPTIAGVGSDGNPEDVTVILNSPTSLVCEAYSYPPATITWFKDGTPLES----- 2618

Query: 379  NREV----AGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRM-------- 426
            NR +     G T+   + Q  +   Y C  +NE G ++ +  V V  +PP +        
Sbjct: 2619 NRNIRILPGGRTLQILNAQEDNAGRYSCVATNEAGEMIKHYEVKVY-IPPIINKGDLWGP 2677

Query: 427  -LSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENG-SLEIKM 484
             LSP+   I+V   N   L+C  +  P  +L W+K+GQ    D  + ++  NG +L+IK 
Sbjct: 2678 GLSPKEVKIKV--NNTLTLECEAYAIPSASLSWYKDGQPLKSDD-HVNIAANGHTLQIKE 2734

Query: 485  IRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPED----QVARRG--------TT 532
             +  D G YTCVA+NI G+ E    + ++ P    ++ E        R G          
Sbjct: 2735 AQISDTGRYTCVASNIAGEDELDFDVNIQVPPSFQKLWEIGNMLDTGRNGEAKDVIINNP 2794

Query: 533  VQLECRVKHDPSLKLTVSWLKDDEPLYIGNR--MKKEDDSLTIFGVAERDQGSYTCVAST 590
            + L C     P   LT  W KD  PL   ++  +      L I      D G YTCVA  
Sbjct: 2795 ISLYCETNAAPPPTLT--WYKDGHPLTSSDKVLILPGGRVLQIPRAKVEDAGRYTCVAVN 2852

Query: 591  ELDQDLAKAYLTVL 604
            E  +D  +  + VL
Sbjct: 2853 EAGEDSLQYDVRVL 2866



 Score =  138 bits (347), Expect = 2e-32
 Identities = 144/577 (24%), Positives = 233/577 (40%), Gaps = 56/577 (9%)

Query: 57   CEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARN 116
            CEA   P  +  W ++       ++ R+    R+  ++         E+  G Y C A N
Sbjct: 2597 CEAYSYPPATITWFKDGTPLESNRNIRILPGGRTLQIL------NAQEDNAGRYSCVATN 2650

Query: 117  KFGTALSNR-----IRLQVSKSPLW-----PKENLDPVVVQEGAPLTLQCNPPPGLPSPV 166
            + G  + +      I   ++K  LW     PKE    V ++    LTL+C     +PS  
Sbjct: 2651 EAGEMIKHYEVKVYIPPIINKGDLWGPGLSPKE----VKIKVNNTLTLECEAY-AIPSAS 2705

Query: 167  IFWMSSSMEPITQDKRVSQGHNGD-LYFSNVMLQDMQTDYSCNA-------RFHFTHTIQ 218
            + W     +P+  D  V+   NG  L      + D    Y+C A          F   IQ
Sbjct: 2706 LSWYKDG-QPLKSDDHVNIAANGHTLQIKEAQISDTGR-YTCVASNIAGEDELDFDVNIQ 2763

Query: 219  QKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKG 278
               P + + L   G      + +       ++ V+    + L C  +  P P + WYK G
Sbjct: 2764 V--PPSFQKLWEIG------NMLDTGRNGEAKDVIINNPISLYCETNAAPPPTLTWYKDG 2815

Query: 279  GDLPS-DKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWL--- 334
              L S DK       + L+I     ED+G Y C+A N+ G       VRV   P      
Sbjct: 2816 HPLTSSDKVLILPGGRVLQIPRAKVEDAGRYTCVAVNEAGEDSLQYDVRVLVPPIIKGAN 2875

Query: 335  -DEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTII-FRDT 392
             D P+ + +   +   + C ++G+P P   W  +G+PL     + ++ ++   I+   +T
Sbjct: 2876 SDLPEEVTVLVNKSALIECLSSGSPAPRNSWQKDGQPLLE--DDHHKFLSNGRILQILNT 2933

Query: 393  QISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSP 452
            QI+    Y C   N  G       ++V  VPP ++ P+++ + V++ N   L C   G P
Sbjct: 2934 QITDIGRYVCVAENTAGSAKKYFNLNV-HVPPSVIGPKSENLTVVVNNFISLTCEVSGFP 2992

Query: 453  IPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEV 512
             P L W KN Q   L+     V    +L+I   +  D G YTC+A N  G+++ +  L V
Sbjct: 2993 PPDLSWLKNEQPIKLNTNTLIVPGGRTLQIIRAKVSDGGEYTCIAINQAGESKKKFSLTV 3052

Query: 513  KDPTRIYRMPEDQVA----RRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMK--K 566
              P  I     + ++    R GT+V LEC     P   +T  W K+   +     ++   
Sbjct: 3053 YVPPSIKDHDSESLSVVNVREGTSVSLECESNAVPPPVIT--WYKNGRMITESTHVEILA 3110

Query: 567  EDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTV 603
            +   L I      D G Y C A     +D    +L V
Sbjct: 3111 DGQMLHIKKAEVSDTGQYVCRAINVAGRDDKNFHLNV 3147



 Score =  137 bits (345), Expect = 3e-32
 Identities = 141/543 (25%), Positives = 212/543 (39%), Gaps = 33/543 (6%)

Query: 57   CEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARN 116
            CE +G P+P   W +++    + +   +     +G ++  FR+   PE+  G Y C A N
Sbjct: 1382 CEVEGTPSPIIMWYKDN--VQVTESSTIQTVN-NGKILKLFRA--TPED-AGRYSCKAIN 1435

Query: 117  KFGTALSNRIRLQVSKSPLWPKENL-DPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSME 175
              GT+      + V   P     N  + V V     + L+C    G P P I W      
Sbjct: 1436 IAGTS-QKYFNIDVLVPPTIIGTNFPNEVSVVLNRDVALECQVK-GTPFPDIHWFKDGKP 1493

Query: 176  PITQDKRVSQGHNGD-LYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRGVA 234
                D  V     G  L+  N    D +  Y C          +Q     L +       
Sbjct: 1494 LFLGDPNVELLDRGQVLHLKNARRND-KGRYQCTVS---NAAGKQAKDIKLTIYIP---- 1545

Query: 235  ERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDL-PSDKAKFENFNK 293
               PS      T    +++  + + LEC   G+P P I WYK G  +  S +A + +  +
Sbjct: 1546 ---PSIKGGNVTTDISVLINSL-IKLECETRGLPMPAITWYKDGQPIMSSSQALYIDKGQ 1601

Query: 294  ALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYW---LDEPKNLILAPGEDGRL 350
             L I      DS  Y C  +N  G+   +  V V   P     L  P N  +       L
Sbjct: 1602 YLHIPRAQVSDSATYTCHVANVAGTAEKSFHVDVYVPPMIEGNLATPLNKQVVIAHSLTL 1661

Query: 351  VCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGY 410
             C+A GNP P + W+ +G P++ A  N   E  G  +     Q   R  Y C  ++  G 
Sbjct: 1662 ECKAAGNPSPILTWLKDGVPVK-ANDNIRIEAGGKKLEIMSAQEIDRGQYICVATSVAGE 1720

Query: 411  LLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGG 470
                  V VL  P            V++ N   LDC   GSP PT+ W K+GQ  +   G
Sbjct: 1721 KEIKYEVDVLVPPAIEGGDETSYFIVMVNNLLELDCHVTGSPPPTIMWLKDGQLIDERDG 1780

Query: 471  NYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMP-EDQVARR 529
               +     L I   +  + G+Y C+A N  G  + +  + V  P  I      ++V  +
Sbjct: 1781 FKILLNGRKLVIAQAQVSNTGLYRCMAANTAGDHKKEFEVTVHVPPTIKSSGLSERVVVK 1840

Query: 530  GTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAE---RDQGSYTC 586
               V L+C     P+  +T  WLKDD+P+       K   S  +  +A+    D G YTC
Sbjct: 1841 YKPVALQCIANGIPNPSIT--WLKDDQPVNTAQGNLKIQSSGRVLQIAKTLLEDAGRYTC 1898

Query: 587  VAS 589
            VA+
Sbjct: 1899 VAT 1901



 Score =  129 bits (325), Expect = 6e-30
 Identities = 150/599 (25%), Positives = 236/599 (39%), Gaps = 47/599 (7%)

Query: 31   LTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRS 90
            L  P  + + + +D  V  + ++ + CE  GNP P   W ++ +     +   +     S
Sbjct: 2475 LVPPHIVGENTLEDVKVKEKQSVTLTCEVTGNPVPEITWHKDGQPLQEDEAHHII----S 2530

Query: 91   GTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSP----LWPKENLDPVVV 146
            G   +   +   P  + G Y C A +  G   S    L V  SP    +    N + V V
Sbjct: 2531 GGRFLQITNVQVP--HTGRYTCLASSPAGHK-SRSFSLNVFVSPTIAGVGSDGNPEDVTV 2587

Query: 147  QEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYS 206
               +P +L C      P+ + ++   +     ++ R+  G    L   N   +D    YS
Sbjct: 2588 ILNSPTSLVCEAYSYPPATITWFKDGTPLESNRNIRILPG-GRTLQILNAQ-EDNAGRYS 2645

Query: 207  CNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLR-GMDLLLECIAS 265
            C A       I+    + +KV     +       ++  G +  ++ ++    L LEC A 
Sbjct: 2646 CVATNEAGEMIKH---YEVKVYIPPII---NKGDLWGPGLSPKEVKIKVNNTLTLECEAY 2699

Query: 266  GVPTPDIAWYKKGGDLPS-DKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTIS 324
             +P+  ++WYK G  L S D          L+I      D+G Y C+ASN  G       
Sbjct: 2700 AIPSASLSWYKDGQPLKSDDHVNIAANGHTLQIKEAQISDTGRYTCVASNIAGEDELDFD 2759

Query: 325  VRVKAAPYW--LDEPKNLILAPGEDGR-----------LVCRANGNPKPTVQWMVNGEPL 371
            V ++  P +  L E  N+ L  G +G            L C  N  P PT+ W  +G PL
Sbjct: 2760 VNIQVPPSFQKLWEIGNM-LDTGRNGEAKDVIINNPISLYCETNAAPPPTLTWYKDGHPL 2818

Query: 372  QSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRN 431
             S+         G  +     ++     Y C   NE G       V VL VPP +    +
Sbjct: 2819 TSS-DKVLILPGGRVLQIPRAKVEDAGRYTCVAVNEAGEDSLQYDVRVL-VPPIIKGANS 2876

Query: 432  QL---IRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGS-LEIKMIRK 487
             L   + V++     ++C   GSP P   W K+GQ   L+  ++    NG  L+I   + 
Sbjct: 2877 DLPEEVTVLVNKSALIECLSSGSPAPRNSWQKDGQ-PLLEDDHHKFLSNGRILQILNTQI 2935

Query: 488  EDQGIYTCVATNILGKAENQVRLEVK-DPTRIYRMPEDQVARRGTTVQLECRVKHDPSLK 546
             D G Y CVA N  G A+    L V   P+ I    E+        + L C V   P   
Sbjct: 2936 TDIGRYVCVAENTAGSAKKYFNLNVHVPPSVIGPKSENLTVVVNNFISLTCEVSGFPPPD 2995

Query: 547  LTVSWLKDDEPLYIGNR--MKKEDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTV 603
            L  SWLK+++P+ +     +     +L I      D G YTC+A  +  +   K  LTV
Sbjct: 2996 L--SWLKNEQPIKLNTNTLIVPGGRTLQIIRAKVSDGGEYTCIAINQAGESKKKFSLTV 3052



 Score =  124 bits (312), Expect = 2e-28
 Identities = 101/403 (25%), Positives = 174/403 (43%), Gaps = 22/403 (5%)

Query: 213 FTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDI 272
           F   I   +  T +  T   V+E  P    P        V  G   +L C+       ++
Sbjct: 496 FYECIAVSSAGTGRAQTFFDVSEPPPVIQVPNNVT----VTPGERAVLTCLIISAVDYNL 551

Query: 273 AWYKKGGDLP-SDKAKFENF-NKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAA 330
            W +   D+  ++ A+     N +L + +V   D+GEY C+ S++ GS   ++ + V+  
Sbjct: 552 TWQRNDRDVRLAEPARIRTLANLSLELKSVKFNDAGEYHCMVSSEGGSSAASVFLTVQEP 611

Query: 331 PYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFR 390
           P     PKN     G +  ++C A G PKP + W VN   +  +  +  R  +  T+  +
Sbjct: 612 PKVTVMPKNQSFTGGSEVSIMCSATGYPKPKIAWTVNDMFIVGS--HRYRMTSDGTLFIK 669

Query: 391 DTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFG 450
           +       +Y C  SN  G    N+ +  ++ P  M+     L  V L + T ++C   G
Sbjct: 670 NAAPKDAGIYGCLASNSAGTDKQNSTLRYIEAPKLMVVQSELL--VALGDITVMECKTSG 727

Query: 451 SPIPTLRWFKNGQGSNLDGGNYHVYEN--GSLEIKMIRKEDQGIYTCVATNILGKAENQV 508
            P P ++WFK      L    + + +   G L+I+  +  D G YTCVA N  G+A  ++
Sbjct: 728 IPPPQVKWFKGDL--ELRPSTFLIIDPLLGLLKIQETQDLDAGDYTCVAINEAGRATGKI 785

Query: 509 RLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDE------PLYIGN 562
            L+V  P    + P D     G+ V L C V+  P  + T+ W + D       P  + +
Sbjct: 786 TLDVGSPPVFIQEPADVSMEIGSNVTLPCYVQGYP--EPTIKWRRLDNMPIFSRPFSVSS 843

Query: 563 RMKKEDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTVLG 605
             +    +L I  +   D+G+Y C A  +  +  ++  +TV G
Sbjct: 844 ISQLRTGALFILNLWASDKGTYICEAENQFGKIQSETTVTVTG 886



 Score =  101 bits (251), Expect = 2e-21
 Identities = 85/337 (25%), Positives = 139/337 (41%), Gaps = 13/337 (3%)

Query: 272 IAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAP 331
           +++ + G  L  D+   E+ +  L I  V+  D G Y C+A +  G+ R      V   P
Sbjct: 461 LSFVRNGVTLGVDQYLKESASVNLDIAKVTLSDEGFYECIAVSSAGTGRAQTFFDVSEPP 520

Query: 332 YWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRD 391
             +  P N+ + PGE   L C         + W  N   ++ A P   R +A  ++  + 
Sbjct: 521 PVIQVPNNVTVTPGERAVLTCLIISAVDYNLTWQRNDRDVRLAEPARIRTLANLSLELKS 580

Query: 392 TQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGS 451
            + +    Y C  S+E G   A+ F++V + P   + P+NQ       +   + C   G 
Sbjct: 581 VKFNDAGEYHCMVSSEGGSSAASVFLTVQEPPKVTVMPKNQSFTG--GSEVSIMCSATGY 638

Query: 452 PIPTLRWFKNGQ---GSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQV 508
           P P + W  N     GS+     Y +  +G+L IK    +D GIY C+A+N  G  +   
Sbjct: 639 PKPKIAWTVNDMFIVGSH----RYRMTSDGTLFIKNAAPKDAGIYGCLASNSAGTDKQNS 694

Query: 509 RLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKED 568
            L   +  ++  +  + +   G    +EC+    P  +  V W K D  L     +  + 
Sbjct: 695 TLRYIEAPKLMVVQSELLVALGDITVMECKTSGIPPPQ--VKWFKGDLELRPSTFLIIDP 752

Query: 569 --DSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTV 603
               L I    + D G YTCVA  E  +   K  L V
Sbjct: 753 LLGLLKIQETQDLDAGDYTCVAINEAGRATGKITLDV 789


>gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens]
          Length = 3874

 Score =  181 bits (460), Expect = 1e-45
 Identities = 165/587 (28%), Positives = 245/587 (41%), Gaps = 47/587 (8%)

Query: 34   PPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTR-NSRFFNIAKDPRVSMRRRSGT 92
            PPTI      D  V     +++ C + G PAP+  W++  ++        RVS    SG 
Sbjct: 2665 PPTIADDQT-DFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLGARGSGYRVSP---SGA 2720

Query: 93   LVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLW-PKENLDPVVVQEGAP 151
            L I    G     + G Y C ARN  G A    + L V  SP+  P  ++   V +E   
Sbjct: 2721 LEI----GQALPIHAGRYTCSARNSAGVA-HKHVFLTVQASPVVKPLPSVVRAVAEEEVL 2775

Query: 152  LTLQCNPPPGLPSPVIFWMSSSMEPITQ-DKRVSQGHNGDLYFSNVMLQDMQTDYSCNAR 210
            L  + +   G+P P I W    +   T    +V  G  G L  ++   +D   +Y C A 
Sbjct: 2776 LPCEAS---GIPRPTITWQKEGLNVATGVSTQVLPG--GQLRIAHASPEDAG-NYLCIA- 2828

Query: 211  FHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTP 270
                     KN     +  TR V +  P     +          G    L C A G P P
Sbjct: 2829 ---------KNSAGSAMGKTRLVVQVPPVI---ENGLPDLSTTEGSHAFLPCKARGSPEP 2876

Query: 271  DIAWYKKGGDLPSDKAKFE-NFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKA 329
            +I W K G  +   + KF    +  L + N+  +D+G Y C A N +G  R  + + +  
Sbjct: 2877 NITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRARRRVHLTILV 2936

Query: 330  APYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIF 389
             P +   P +  L  G+   L C A G+P P + W VN  P+       + +  G T+  
Sbjct: 2937 LPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEGV---SEQDGGSTLQR 2993

Query: 390  RDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFF 449
                      Y C   N  G   A +FV V + P       + L+  +     +LDC   
Sbjct: 2994 AAVSREDSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPV-GGSIQLDCVVR 3052

Query: 450  GSPIPTLRWFKNG---QGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAEN 506
            G P+P + W K+G   +GS+L     H  +NGSL I    ++D G Y C+A N +G A+ 
Sbjct: 3053 GDPVPDIHWIKDGLPLRGSHLR----HQLQNGSLTIHRTERDDAGRYQCLAENEMGVAKK 3108

Query: 507  QVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKK 566
             V L ++        P+D   R G  V L C+   +P+   T+ WL+  +PL    R++ 
Sbjct: 3109 VVILVLQSAPVFQVEPQDMTVRSGDDVALRCQATGEPT--PTIEWLQAGQPLRASRRLRT 3166

Query: 567  -EDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTVLGNCPCSPW 612
              D SL +  V   D G+Y CVA   L    A+A+L V G  P   W
Sbjct: 3167 LPDGSLWLENVETGDAGTYDCVAHNLLGSATARAFLVVRGE-PQGSW 3212



 Score =  156 bits (395), Expect = 5e-38
 Identities = 153/604 (25%), Positives = 252/604 (41%), Gaps = 55/604 (9%)

Query: 35   PTI---TKQSAKDHIVDPRDN-ILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRS 90
            PTI    + SA + +    +N I + CEA   P+P+  W ++   F  +++ ++ +    
Sbjct: 1346 PTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGAPFEASRNIQL-LPGTH 1404

Query: 91   GTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNR-----IRLQVSKSPLWPKENLDPVV 145
            G  +++ +     +E  G+Y C   N+ G A+ N      I   +SK     +  +  V 
Sbjct: 1405 GLQILNAQ-----KEDAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLGEVGVKEVK 1459

Query: 146  VQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDY 205
             +  + LTL+C     +P P I W     +P+T   R+     G L      LQ   T  
Sbjct: 1460 TKVNSTLTLECESW-AVPPPTIRWYKDG-QPVTPSSRLQVLGEGRL------LQIQPTQV 1511

Query: 206  SCNARFHFTHT------------IQQKNPFTLKVLTTRGVAERTPSFMYPQGTASS-QMV 252
            S + R+    T            + Q  P   KV       E        +G  +  + +
Sbjct: 1512 SDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREI 1571

Query: 253  LRGMDLLLECIASGVPTPDIAWYKKGGDLPS-DKAKFENFNKALRITNVSEEDSGEYFCL 311
            +      L C  + +P PD+ WY++   L + D+       + L+I  V  E++G Y C 
Sbjct: 1572 VENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCK 1631

Query: 312  ASNKMGSIRHTISVRVKAAPYWLDEPKNLI----LAPGEDGRLVCRANGNPKPTVQWMVN 367
            ASN++G       + V   P  L + + L+    +       L C A GNP PT+ W+ N
Sbjct: 1632 ASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQN 1691

Query: 368  GEPLQSAPPNPNREVAGDTIIFR--DTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPR 425
            G P     P+P  +V  D  + +    +++  A Y C   N+ G      F   + VPPR
Sbjct: 1692 GLPFS---PSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSA-EKLFTLRVQVPPR 1747

Query: 426  MLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMI 485
            +     + +  IL +   L C     P P + W+K+ Q  +L    + +    +L++   
Sbjct: 1748 IAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGTHTLQLGRA 1807

Query: 486  RKEDQGIYTCVATNILGKAENQVRLEVKDP---TRIYRMPEDQV-ARRGTTVQLECRVKH 541
            R  D G+YTC A N  G+ +  V+L V  P    +  R P+D V  R G    L C    
Sbjct: 1808 RLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCET-- 1865

Query: 542  DPSLKLTVSWLKDDEPLYIGNRMK--KEDDSLTIFGVAERDQGSYTCVASTELDQDLAKA 599
            D   + TV+W KD +PL +  R +  +    L I      D+G Y+C  S    + +   
Sbjct: 1866 DALPEPTVTWYKDGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTF 1925

Query: 600  YLTV 603
             LTV
Sbjct: 1926 TLTV 1929



 Score =  156 bits (394), Expect = 6e-38
 Identities = 152/563 (26%), Positives = 234/563 (41%), Gaps = 70/563 (12%)

Query: 51   DNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYE--- 107
            D  ++ CE    P P+  W ++ +       P V  +R         R G R E  E   
Sbjct: 1857 DKAVLSCETDALPEPTVTWYKDGQ-------PLVLAQRTQA-----LRGGQRLEIQEAQV 1904

Query: 108  ---GEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPS 164
               G Y C   N  G A+     L V   P +     + V    G+PL L C+   G+P+
Sbjct: 1905 SDKGLYSCKVSNVAGEAVRT-FTLTVQVPPTFENPKTETVSQVAGSPLVLTCDVS-GVPA 1962

Query: 165  PVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFT 224
            P + W+   M   +          G L  S +      T Y+C A        + +  F 
Sbjct: 1963 PTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGT-YTCVAE---NTQAEARKDFV 2018

Query: 225  LKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSD 284
            + VL    VA R  S     G A    VL G ++ L+C A G P PD+AW K G  L  D
Sbjct: 2019 VAVL----VAPRIRS----SGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQD 2070

Query: 285  KAKFENF---NKALRITNVSEEDSGEYFCLASNKMG--SIRHTISVRV-KAAPYWLDEPK 338
                  F     +L +  +   D+G Y C+A N  G  +  HT++V V        D   
Sbjct: 2071 MGPHLRFYLDGGSLVLKGLRASDAGAYTCVAHNPAGEDARLHTVNVLVPPTIKQGADGSG 2130

Query: 339  NLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREV---AGDTIIFRDTQIS 395
             L+  PGE   +VC   G+P   V W+ +G PL    P   R +   +G T+     Q++
Sbjct: 2131 TLVSRPGELVTMVCPVRGSPPIHVSWLKDGLPL----PLSQRTLLHGSGHTLRISKVQLA 2186

Query: 396  SRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSP---RNQLIRVILYNRTRLDCPFFGSP 452
               ++ C  ++  G    N F   + VPP +L P   +N ++ V+  +   L C   G P
Sbjct: 2187 DAGIFTCVAASPAGVADRN-FTLQVQVPP-VLEPVEFQNDVV-VVRGSLVELPCEARGVP 2243

Query: 453  IPTLRWFKNGQ---GSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVR 509
            +P + W K+G+     +L+ G        SL+++ +   D G Y+CVA +  G+A    +
Sbjct: 2244 LPLVSWMKDGEPLLSQSLEQG-------PSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQ 2296

Query: 510  LEVKDPTRI--YRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKE 567
            L V +P  I     P +     G  ++L C  +  P   +T  W KD + L      + E
Sbjct: 2297 LTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNIT--WHKDGQAL-----TRLE 2349

Query: 568  DDSLTIFGVAERDQGSYTCVAST 590
            ++S     +  RD G YTC+A +
Sbjct: 2350 NNSRATRVLRVRDAGLYTCLAES 2372



 Score =  151 bits (382), Expect = 1e-36
 Identities = 149/571 (26%), Positives = 230/571 (40%), Gaps = 37/571 (6%)

Query: 34   PPTI---TKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRS 90
            PP I   T++  ++  V+    + ++C A GNP P+  W +N   F+    PR+ +    
Sbjct: 1650 PPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFS--PSPRLQVLEDG 1707

Query: 91   GTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGA 150
              L +              Y C A N+ G+A      L+V   P     +L+ V     +
Sbjct: 1708 QVLQVSTAEVADA----ASYMCVAENQAGSA-EKLFTLRVQVPPRIAGLDLEQVTAILNS 1762

Query: 151  PLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNAR 210
             ++L C+     P+P + W   S      ++         L      L D    Y+C A 
Sbjct: 1763 SVSLPCDVHAH-PNPEVTWYKDSQALSLGEEVFLLPGTHTLQLGRARLSDSGM-YTCEA- 1819

Query: 211  FHFTHTIQQKNPFTLKVLTTRGVAERTPSFMY-PQGTASSQMVLRGMDLLLECIASGVPT 269
                   + +    L VL         P+F   P+G   + +V  G   +L C    +P 
Sbjct: 1820 --LNAAGRDQKLVQLSVLVP-------PAFRQAPRGPQDAVLVRVGDKAVLSCETDALPE 1870

Query: 270  PDIAWYKKGGDLP-SDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVK 328
            P + WYK G  L  + + +     + L I      D G Y C  SN  G    T ++ V+
Sbjct: 1871 PTVTWYKDGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQ 1930

Query: 329  AAPYWLDEPKNLILA--PGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDT 386
              P + + PK   ++   G    L C  +G P PTV W+ +  P++S+  +      G  
Sbjct: 1931 VPPTF-ENPKTETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPVESSAVHGVVSRGGRL 1989

Query: 387  IIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDC 446
             + R  Q +    Y C   N       +  V+VL  P    S   +   V+     RLDC
Sbjct: 1990 QLSR-LQPAQAGTYTCVAENTQAEARKDFVVAVLVAPRIRSSGVAREHHVLEGQEVRLDC 2048

Query: 447  PFFGSPIPTLRWFKNGQGSNLDGGNY--HVYENGSLEIKMIRKEDQGIYTCVATNILGKA 504
               G P P + W K+G     D G +     + GSL +K +R  D G YTCVA N  G+ 
Sbjct: 2049 EADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVAHNPAGED 2108

Query: 505  ENQVRLEVKDPTRIYRMPEDQ---VARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIG 561
                 + V  P  I +  +     V+R G  V + C V+  P +   VSWLKD  PL + 
Sbjct: 2109 ARLHTVNVLVPPTIKQGADGSGTLVSRPGELVTMVCPVRGSPPIH--VSWLKDGLPLPLS 2166

Query: 562  NR--MKKEDDSLTIFGVAERDQGSYTCVAST 590
             R  +     +L I  V   D G +TCVA++
Sbjct: 2167 QRTLLHGSGHTLRISKVQLADAGIFTCVAAS 2197



 Score =  150 bits (380), Expect = 3e-36
 Identities = 144/580 (24%), Positives = 228/580 (39%), Gaps = 37/580 (6%)

Query: 31   LTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRS 90
            L  P   +   A++H V     + ++CEA G P P   W ++         P +      
Sbjct: 2022 LVAPRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDG 2081

Query: 91   GTLVIDFRSGGRPEEYEGEYQCFARNKFG-TALSNRIRLQVSKSPLWPKENLDPVVVQEG 149
            G+LV+     G      G Y C A N  G  A  + + + V  +     +    +V + G
Sbjct: 2082 GSLVLK----GLRASDAGAYTCVAHNPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRPG 2137

Query: 150  APLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNA 209
              +T+ C P  G P   + W+   +      + +  G    L  S V L D    ++C A
Sbjct: 2138 ELVTMVC-PVRGSPPIHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGI-FTCVA 2195

Query: 210  RFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPT 269
                   +  +N FTL+V        + P  + P    +  +V+RG  + L C A GVP 
Sbjct: 2196 A--SPAGVADRN-FTLQV--------QVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPL 2244

Query: 270  PDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKA 329
            P ++W K G  L S   +      +L++  V   DSG Y C+A ++ G  R    + V  
Sbjct: 2245 PLVSWMKDGEPLLSQSLE---QGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVME 2301

Query: 330  APYWLD--EPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTI 387
             P+  D  +P  L L PG    L+C A G P+P + W  +G+ L     N          
Sbjct: 2302 PPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQALTRLENNSRAT------ 2355

Query: 388  IFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRN-QLIRVILYNRTRLDC 446
              R  ++    +Y C   +  G  +  +F   +  PP ++ PR  + +  +   +  L+C
Sbjct: 2356 --RVLRVRDAGLYTCLAESPAG-AIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLVLEC 2412

Query: 447  PFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAEN 506
                 P P + W ++G     D           L+++ +   D G Y+C A N  G    
Sbjct: 2413 SVEAEPAPKITWHRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSV 2472

Query: 507  QVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKK 566
              R+E+     I   P         T  L C+    P+    VSW KD  PL   +   +
Sbjct: 2473 AFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPA--PLVSWRKDRVPLDPRSPRFE 2530

Query: 567  --EDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTVL 604
               + SL I  V  +D G Y C+AS     D     L VL
Sbjct: 2531 ILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVL 2570



 Score =  150 bits (378), Expect = 4e-36
 Identities = 148/606 (24%), Positives = 242/606 (39%), Gaps = 58/606 (9%)

Query: 19   LSLGGAIEIPMDLTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNI 78
            L  G  + +P  +T PP++         V     + + C A G P+P+  W ++    + 
Sbjct: 776  LRYGLRVNVPPRITLPPSLPGP------VLVNTPVRLTCNATGAPSPTLMWLKDGNPVSP 829

Query: 79   AKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPK 138
            A  P + +      L +   +  R  +  G Y C A +  G    + + LQV   P    
Sbjct: 830  AGTPGLQVFPGGRVLTL---ASARASD-SGRYSCVAVSAVGEDRQDVV-LQVHMPPSILG 884

Query: 139  ENLD-PVVVQEGAPLTLQCNPPPGLPSPVIFWMSSS--MEP-----ITQDKRVSQGHNGD 190
            E L+  VV  E   L  Q +    +P PV+ W      +EP     ++ DK + Q    D
Sbjct: 885  EELNVSVVANESVALECQSH---AMPPPVLSWWKDGRPLEPRPGVHLSADKALLQVDRAD 941

Query: 191  LYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQ 250
            ++ +          Y+C A        + +  + L V             ++P   + + 
Sbjct: 942  VWDAG--------HYTCEA---LNQAGRSEKHYNLNVWVAP---------VFPLRESHTL 981

Query: 251  MVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEED---SGE 307
             V  G    L C   GVP P I+W K G  LP + A  ++ +   R+  + +      G 
Sbjct: 982  TVREGHPTSLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGT 1041

Query: 308  YFCLASNKMGSIRHTISVRVKAAPYWL---DEPKNLILAPGEDGRLVCRANGNPKPTVQW 364
            Y C  SN +G+    + + V   P      + P  + +       L C A G P PTV W
Sbjct: 1042 YTCECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTW 1101

Query: 365  MVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPP 424
              +G+P+  A      +  G ++     Q +    Y C   N  G       +SVL VPP
Sbjct: 1102 ERDGQPV-GAELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVL-VPP 1159

Query: 425  RMLSPRNQL--IRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEI 482
             ++   + L  I   L++   L C   G P P +RWF+  +  +     Y +     L++
Sbjct: 1160 ELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGWMLKM 1219

Query: 483  KMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVAR--RGTTVQLECRVK 540
               +++D G+Y+C+A+N  G+A     +EV  P  I     ++V +   G T  L C V 
Sbjct: 1220 TQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVT 1279

Query: 541  HDPSLKLTVSWLKDDEPLYIGNRMKKEDDS--LTIFGVAERDQGSYTCVASTELDQDLAK 598
              P  KLT  W KD  PL  G+      D   L +        G Y+C+A+  + +    
Sbjct: 1280 GHPQPKLT--WFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKH 1337

Query: 599  AYLTVL 604
              L+VL
Sbjct: 1338 FQLSVL 1343



 Score =  149 bits (376), Expect = 7e-36
 Identities = 151/580 (26%), Positives = 225/580 (38%), Gaps = 38/580 (6%)

Query: 29   MDLTQPPTITKQSAKDHI-VDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMR 87
            + + +PP I        + + P   + + C+A+G P P+  W ++ +        R+   
Sbjct: 2297 LTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQALT-----RLENN 2351

Query: 88   RRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTA-LSNRIRLQVSKSPLWPKENLDPVVV 146
             R+ T V+  R  G        Y C A +  G    S R+R+Q   + + P+     V +
Sbjct: 2352 SRA-TRVLRVRDAGL-------YTCLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGL 2403

Query: 147  QEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYS 206
              G  L L+C+     P+P I W    +  + +D        G       +      DYS
Sbjct: 2404 APGQ-LVLECSVEAE-PAPKITWHRDGIV-LQEDAHTQFPERGRFLQLQALSTADSGDYS 2460

Query: 207  CNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASG 266
            C AR     T      F +++ T   +    P+            V      LL C A G
Sbjct: 2461 CTARNAAGST---SVAFRVEIHTVPTIRSGPPAVN----------VSVNQTALLPCQADG 2507

Query: 267  VPTPDIAWYKKGGDLPSDKAKFENFNK-ALRITNVSEEDSGEYFCLASNKMGSIRHTISV 325
            VP P ++W K    L     +FE   + +LRI  V  +D+G Y CLASN  GS R    +
Sbjct: 2508 VPAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDL 2567

Query: 326  RVKAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQ-SAPPNPNREVAG 384
            RV   P     P NL L       L C A+G+PKP V W  +G+ L         R +  
Sbjct: 2568 RVLEPPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPS 2627

Query: 385  DTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRL 444
            + ++         A ++C  SNE G      +   + VPP +   +     V +     L
Sbjct: 2628 NALLLTAPGPQDSAQFECVVSNEVGE-AHRLYQVTVHVPPTIADDQTD-FTVTMMAPVVL 2685

Query: 445  DCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKA 504
             C   G P PT+ W K G      G  Y V  +G+LEI        G YTC A N  G A
Sbjct: 2686 TCHSTGIPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGVA 2745

Query: 505  ENQVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIG-NR 563
               V L V+    +  +P    A     V L C     P  + T++W K+   +  G + 
Sbjct: 2746 HKHVFLTVQASPVVKPLPSVVRAVAEEEVLLPCEASGIP--RPTITWQKEGLNVATGVST 2803

Query: 564  MKKEDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTV 603
                   L I   +  D G+Y C+A       + K  L V
Sbjct: 2804 QVLPGGQLRIAHASPEDAGNYLCIAKNSAGSAMGKTRLVV 2843



 Score =  143 bits (360), Expect = 5e-34
 Identities = 145/562 (25%), Positives = 224/562 (39%), Gaps = 45/562 (8%)

Query: 55   IECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFA 114
            + CE +G P P   W ++ +     +   +      G L+     G      EG Y C  
Sbjct: 991  LSCECRGVPFPKISWRKDGQPLP-GEGAGLQHVSAVGRLLY---LGQAQLAQEGTYTCEC 1046

Query: 115  RNKFGTALSNRIRLQVSKSP--LWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSS 172
             N  G + S  ++L+V   P    P+E    V V +    TL+CN   G P P + W   
Sbjct: 1047 SNVVGNS-SQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNAT-GKPPPTVTWERD 1104

Query: 173  SMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRG 232
              +P+  +  +   + G               YSC A  +     ++K  F L VL    
Sbjct: 1105 G-QPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAE-NLAGRAERK--FELSVLVP-- 1158

Query: 233  VAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDL-PSDKAKFENF 291
                 P  +      ++        L L C A G+P P I W++    + P +       
Sbjct: 1159 -----PELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAG 1213

Query: 292  NKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILA--PGEDGR 349
               L++T   E+DSG Y CLASN+ G  R   SV V   P   +E    ++    G+   
Sbjct: 1214 GWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAH 1273

Query: 350  LVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQ--ISSRAVYQCNTSNE 407
            L+C   G+P+P + W  +G PL     +    ++ D ++ +  Q  +SS   Y C  +N 
Sbjct: 1274 LMCNVTGHPQPKLTWFKDGRPLARGDAH---HISPDGVLLQVLQANLSSAGHYSCIAANA 1330

Query: 408  HGYLLANAFVSVLDVPPRMLSPRNQL---IRVILYNRTRLDCPFFGSPIPTLRWFKNGQG 464
             G    +  +SVL  P  +    +     + V + N   L C     P P + W K+G  
Sbjct: 1331 VGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGAP 1390

Query: 465  SNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPED 524
                     +     L+I   +KED G YTCV TN LG+A     +EV  P  I +  +D
Sbjct: 1391 FEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSISK--DD 1448

Query: 525  QVARRG---------TTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMK--KEDDSLTI 573
             +   G         +T+ LEC     P    T+ W KD +P+   +R++   E   L I
Sbjct: 1449 PLGEVGVKEVKTKVNSTLTLECESWAVP--PPTIRWYKDGQPVTPSSRLQVLGEGRLLQI 1506

Query: 574  FGVAERDQGSYTCVASTELDQD 595
                  D G Y CVA+    +D
Sbjct: 1507 QPTQVSDSGRYLCVATNVAGED 1528



 Score =  141 bits (355), Expect = 2e-33
 Identities = 150/598 (25%), Positives = 241/598 (40%), Gaps = 84/598 (14%)

Query: 55   IECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFA 114
            +EC A G P P+  W R+ +   +  +  + ++ +  +L ++         + G Y C A
Sbjct: 1087 LECNATGKPPPTVTWERDGQ--PVGAELGLQLQNQGQSLHVERAQAA----HTGRYSCVA 1140

Query: 115  RNKFGTALSNRIRLQVSKSPLWPKE---NLDPVVVQEGA---PLTLQCNPPPGLPSPVIF 168
             N     L+ R   +   S L P E   +LDP+     A   PLTL C    G+P P I 
Sbjct: 1141 EN-----LAGRAERKFELSVLVPPELIGDLDPLTNITAALHSPLTLLCEAM-GIPPPAIR 1194

Query: 169  WMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTD------YSCNARFHFTHTIQQKNP 222
            W     EP      VS G +  L     ML+  QT       YSC A        + +  
Sbjct: 1195 WFRGE-EP------VSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLAS---NEAGEARRN 1244

Query: 223  FTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLP 282
            F+++VL         P  +  +       VL G    L C  +G P P + W+K G  L 
Sbjct: 1245 FSVEVLV--------PPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLA 1296

Query: 283  -SDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWL-----DE 336
              D          L++   +   +G Y C+A+N +G       + V  AP  L       
Sbjct: 1297 RGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPTILGGAEDSA 1356

Query: 337  PKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDT--IIFRDTQI 394
             + + +       L+C A   P P + WM +G P +++    N ++   T  +   + Q 
Sbjct: 1357 DEEVTVTVNNPISLICEALAFPSPNITWMKDGAPFEASR---NIQLLPGTHGLQILNAQK 1413

Query: 395  SSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLS--PRNQL----IRVILYNRTRLDCPF 448
                 Y C  +NE G  + N  V VL +PP +    P  ++    ++  + +   L+C  
Sbjct: 1414 EDAGQYTCVVTNELGEAVKNYHVEVL-IPPSISKDDPLGEVGVKEVKTKVNSTLTLECES 1472

Query: 449  FGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQV 508
            +  P PT+RW+K+GQ          + E   L+I+  +  D G Y CVATN+ G+ +   
Sbjct: 1473 WAVPPPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDF 1532

Query: 509  RLEVKDPTRIYR----------MPEDQVARRGTT----------VQLECRVKHDPSLKLT 548
             + ++ P    +          +  ++ AR G T            L C     P   LT
Sbjct: 1533 NVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLT 1592

Query: 549  VSWLKDDEPLYIGNRMK--KEDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTVL 604
              W ++D+PL  G+ +   +    L I  V   + G Y+C AS E+ +D     L VL
Sbjct: 1593 --WYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVGEDWLHYELLVL 1648



 Score =  134 bits (337), Expect = 2e-31
 Identities = 154/610 (25%), Positives = 246/610 (40%), Gaps = 55/610 (9%)

Query: 29   MDLTQPPTITKQSAKDHI-VDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMR 87
            +++  PP+I  +  ++ I V       + C   G+P P   W ++ R         +S  
Sbjct: 1247 VEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHISP- 1305

Query: 88   RRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPL---WPKENLDP- 143
               G L+   ++        G Y C A N  G   +   +L V  +P      +++ D  
Sbjct: 1306 --DGVLLQVLQAN---LSSAGHYSCIAANAVGEK-TKHFQLSVLLAPTILGGAEDSADEE 1359

Query: 144  VVVQEGAPLTLQCNPPPGLPSPVIFWMSSSME-PITQDKRVSQGHNGDLYFSNVMLQDMQ 202
            V V    P++L C      PSP I WM        +++ ++  G +G L   N   +D  
Sbjct: 1360 VTVTVNNPISLICEAL-AFPSPNITWMKDGAPFEASRNIQLLPGTHG-LQILNAQKEDAG 1417

Query: 203  TDYSCNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLEC 262
              Y+C         ++    + ++VL    +++  P          +++      L LEC
Sbjct: 1418 -QYTCVVTNELGEAVKN---YHVEVLIPPSISKDDPLGEVGVKEVKTKV---NSTLTLEC 1470

Query: 263  IASGVPTPDIAWYKKGGDL-PSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRH 321
             +  VP P I WYK G  + PS + +     + L+I      DSG Y C+A+N  G    
Sbjct: 1471 ESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQ 1530

Query: 322  TISVRVKAAPYWLD----EPKNLILAPGEDGR----------------LVCRANGNPKPT 361
              +V ++  P +           IL+  E+ R                L C  N  P P 
Sbjct: 1531 DFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPD 1590

Query: 362  VQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLD 421
            + W    +PL SA    +    G  +     +  +   Y C  SNE G    +  + VL 
Sbjct: 1591 LTWYREDQPL-SAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVGEDWLHYELLVL- 1648

Query: 422  VPPRMLSPRNQLIRVILYNRTR---LDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENG 478
             PP +L    +L+  +  N +    L CP  G+P+PT+ W +NG   +       V E+G
Sbjct: 1649 TPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFS-PSPRLQVLEDG 1707

Query: 479  S-LEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQV-ARRGTTVQLE 536
              L++      D   Y CVA N  G AE    L V+ P RI  +  +QV A   ++V L 
Sbjct: 1708 QVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQVPPRIAGLDLEQVTAILNSSVSLP 1767

Query: 537  CRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTI-FGVAE-RDQGSYTCVASTELDQ 594
            C V   P+ ++T  W KD + L +G  +     + T+  G A   D G YTC A     +
Sbjct: 1768 CDVHAHPNPEVT--WYKDSQALSLGEEVFLLPGTHTLQLGRARLSDSGMYTCEALNAAGR 1825

Query: 595  DLAKAYLTVL 604
            D     L+VL
Sbjct: 1826 DQKLVQLSVL 1835



 Score =  133 bits (335), Expect = 4e-31
 Identities = 147/571 (25%), Positives = 220/571 (38%), Gaps = 77/571 (13%)

Query: 55   IECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFA 114
            + C+A G+P P+  W +N R     +   V +  +  TL ID        ++ G + C A
Sbjct: 518  LPCQASGSPVPTIQWLQNGR--PAEELAGVQVASQGTTLHIDHVE----LDHSGLFACQA 571

Query: 115  RNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQ------EGAPLTLQCNPP--------- 159
             N+ GTA +    ++VS    W    L+  + Q        +     C+PP         
Sbjct: 572  TNEAGTAGAE---VEVSVHGEWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGAHP 628

Query: 160  -----PGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFT 214
                  G  SP   W   +  P      V+      L    V L+D +  Y+C A     
Sbjct: 629  KPPLVEGWCSPGSLWGEPTGIP------VAYSLPPPLQIEKVDLRD-EGIYTCAAT---N 678

Query: 215  HTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAW 274
               + K    LKVL    +          +    ++ VL    + LEC+ASGVP PD++W
Sbjct: 679  LAGESKREVALKVLVPPNI----------EPGPVNKAVLENASVTLECLASGVPPPDVSW 728

Query: 275  YKKGGDLPSDKAKFENFN-KALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYW 333
            +K    + S      + + + LRI      D+G Y C+ASN  GS      +RV      
Sbjct: 729  FKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRYGLRVNV---- 784

Query: 334  LDEPKNLILAPGEDG--------RLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREV--A 383
               P  + L P   G        RL C A G P PT+ W+ +G P+  A   P  +V   
Sbjct: 785  ---PPRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPA-GTPGLQVFPG 840

Query: 384  GDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTR 443
            G  +     + S    Y C   +  G    +  + V  +PP +L      + V+      
Sbjct: 841  GRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQV-HMPPSILGEELN-VSVVANESVA 898

Query: 444  LDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGK 503
            L+C     P P L W+K+G+      G +   +   L++      D G YTC A N  G+
Sbjct: 899  LECQSHAMPPPVLSWWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGR 958

Query: 504  AENQVRLEV-KDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPL---Y 559
            +E    L V   P    R       R G    L C  +  P  K  +SW KD +PL    
Sbjct: 959  SEKHYNLNVWVAPVFPLRESHTLTVREGHPTSLSCECRGVPFPK--ISWRKDGQPLPGEG 1016

Query: 560  IGNRMKKEDDSLTIFGVAE-RDQGSYTCVAS 589
             G +       L   G A+   +G+YTC  S
Sbjct: 1017 AGLQHVSAVGRLLYLGQAQLAQEGTYTCECS 1047



 Score =  129 bits (324), Expect = 8e-30
 Identities = 127/508 (25%), Positives = 200/508 (39%), Gaps = 44/508 (8%)

Query: 34  PPTITKQSAKDHIVDPR-DNILIECEAKGNPAPSFHWTRNSRFFNIAKDPR-----VSMR 87
           PP+I +   K ++      ++ +EC+A G P P   W ++++   +          +   
Sbjct: 94  PPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWG 153

Query: 88  RRSGTLVIDF------------RSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPL 135
           +  G  ++D             RSG R  +  G  Q  A    G A   +     + SP 
Sbjct: 154 QVGGHRLLDEGQSLHFPRIQPGRSGRRGAQAGGSAQTKAPWXAGLAGFEQFPTPHAFSPP 213

Query: 136 WPKENLDPVVVQE-----GAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGD 190
            P   L     QE     GA + LQC    G+P+P + W       +     +    +G 
Sbjct: 214 APPSVLGAGAAQEVLGLAGADVELQCWTS-GVPTPQVEWTKDRQPVLPGGPHLQVQEDGQ 272

Query: 191 LYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQ 250
           +          +  Y C A   F+   QQ   F L+V          P  ++        
Sbjct: 273 VLRITGSHVGDEGRYQCVA---FSPAGQQARDFQLRV--------HAPPTIWGSNETGEV 321

Query: 251 MVLRGMDLLLECIASGVPTPDIAWYKKGGDLP-SDKAKFENFNKALRITNVSEEDSGEYF 309
            V+    + L C A GVPTP+I W+K G  LP S K  +    + L++      D+G Y 
Sbjct: 322 AVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYT 381

Query: 310 CLASNKMGSIRHTISVRVKAAPYWLD---EPKNLILAPGEDGRLVCRANGNPKPTVQWMV 366
           C ASN +G+      + V   P        P  +    G    L C A G+P PT+ W  
Sbjct: 382 CKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHH 441

Query: 367 NGEPLQSAPPNPNR-EVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPR 425
            G P+  A  N +R E  G  +       +S  +Y C  S+  G  +    V V  VPP+
Sbjct: 442 EGLPV--AESNESRLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEV-QVPPQ 498

Query: 426 MLSPRNQ-LIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKM 484
           +L       +  I+     L C   GSP+PT++W +NG+ +    G     +  +L I  
Sbjct: 499 LLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDH 558

Query: 485 IRKEDQGIYTCVATNILGKAENQVRLEV 512
           +  +  G++ C ATN  G A  +V + V
Sbjct: 559 VELDHSGLFACQATNEAGTAGAEVEVSV 586



 Score =  129 bits (324), Expect = 8e-30
 Identities = 152/573 (26%), Positives = 224/573 (39%), Gaps = 30/573 (5%)

Query: 29  MDLTQPPTITKQSAKDHIVDPRDN--ILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSM 86
           +D+  PPTI     + ++V       + +EC A+G+P+P+  W         + + R+  
Sbjct: 397 LDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNESRL-- 454

Query: 87  RRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTA-LSNRIRLQVSKSPLWPKENLDPVV 145
              +   V+   S G  E   G Y C A +  G A L   + +QV    L   E L  V 
Sbjct: 455 --ETDGSVLRLESPG--EASSGLYSCVASSPAGEAVLQYSVEVQVPPQ-LLVAEGLGQVT 509

Query: 146 VQEGAPLTLQCNPPPGLPSPVIFWMSSS--MEPITQDKRVSQGHNGDLYFSNVMLQDMQT 203
              G PL L C    G P P I W+ +    E +   +  SQG    L+  +V L D   
Sbjct: 510 TIVGQPLELPCQ-ASGSPVPTIQWLQNGRPAEELAGVQVASQGTT--LHIDHVEL-DHSG 565

Query: 204 DYSCNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECI 263
            ++C A  +   T   +   ++      GV E  P   Y  G           D  +   
Sbjct: 566 LFACQAT-NEAGTAGAEVEVSVHGEWAPGVLE-VPIGQYHWGXEHHSSFPAACDPPVHRG 623

Query: 264 ASGVPTPDI--AWYKKGG--DLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSI 319
               P P +   W   G     P+      +    L+I  V   D G Y C A+N  G  
Sbjct: 624 WGAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIYTCAATNLAGES 683

Query: 320 RHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPN 379
           +  ++++V   P     P N  +       L C A+G P P V W    +P+ S+     
Sbjct: 684 KREVALKVLVPPNIEPGPVNKAVLENASVTLECLASGVPPPDVSWFKGHQPV-SSWMGVT 742

Query: 380 REVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILY 439
             V G  +     Q+S    Y+C  SN  G       + V +VPPR+  P +    V++ 
Sbjct: 743 VSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRYGLRV-NVPPRITLPPSLPGPVLVN 801

Query: 440 NRTRLDCPFFGSPIPTLRWFKNGQGSNLDG-GNYHVYENGS-LEIKMIRKEDQGIYTCVA 497
              RL C   G+P PTL W K+G   +  G     V+  G  L +   R  D G Y+CVA
Sbjct: 802 TPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVA 861

Query: 498 TNILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEP 557
            + +G+    V L+V  P  I     +       +V LEC+    P   L  SW KD  P
Sbjct: 862 VSAVGEDRQDVVLQVHMPPSILGEELNVSVVANESVALECQSHAMPPPVL--SWWKDGRP 919

Query: 558 L--YIGNRMKKEDDSLTIFGVAERDQGSYTCVA 588
           L    G  +  +   L +      D G YTC A
Sbjct: 920 LEPRPGVHLSADKALLQVDRADVWDAGHYTCEA 952



 Score =  120 bits (301), Expect = 4e-27
 Identities = 107/413 (25%), Positives = 180/413 (43%), Gaps = 34/413 (8%)

Query: 16   LCLL--SLGGAIEIPMDLTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNS 73
            LC+   S G A+     + Q P + +    D       +  + C+A+G+P P+  W ++ 
Sbjct: 2825 LCIAKNSAGSAMGKTRLVVQVPPVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDG 2884

Query: 74   RFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKS 133
            +  + A+       + SG L++    G    +  G Y C A N  G A   R+ L +   
Sbjct: 2885 QPVSGAEGKFTI--QPSGELLVKNLEG----QDAGTYTCTAENAVGRA-RRRVHLTILVL 2937

Query: 134  PLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYF 193
            P++     D  + + G  L L+C    G P+P I W  +   P+T+   VS+   G    
Sbjct: 2938 PVFTTLPGDRSL-RLGDRLWLRC-AARGSPTPRIGWTVND-RPVTEG--VSEQDGGSTLQ 2992

Query: 194  SNVMLQDMQTDYSCNA--RFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQM 251
               + ++    Y C A  R   T  +   +     VL               QG A S +
Sbjct: 2993 RAAVSREDSGTYVCWAENRVGRTQAVSFVHVKEAPVL---------------QGEAFSYL 3037

Query: 252  VLR-GMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFC 310
            V   G  + L+C+  G P PDI W K G  L     + +  N +L I     +D+G Y C
Sbjct: 3038 VEPVGGSIQLDCVVRGDPVPDIHWIKDGLPLRGSHLRHQLQNGSLTIHRTERDDAGRYQC 3097

Query: 311  LASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEP 370
            LA N+MG  +  + + +++AP +  EP+++ +  G+D  L C+A G P PT++W+  G+P
Sbjct: 3098 LAENEMGVAKKVVILVLQSAPVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQP 3157

Query: 371  LQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVP 423
            L+++     R +   ++   + +      Y C   N  G   A AF+ V   P
Sbjct: 3158 LRAS--RRLRTLPDGSLWLENVETGDAGTYDCVAHNLLGSATARAFLVVRGEP 3208



 Score =  119 bits (299), Expect = 6e-27
 Identities = 146/581 (25%), Positives = 230/581 (39%), Gaps = 48/581 (8%)

Query: 57  CEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARN 116
           C   G P P   W +      +   P V++    G+L   F +   P +  G+Y+C A N
Sbjct: 24  CGTHGTPKPQVTWRKGPSSEPLHGQPGVAVLEE-GSL---FLASVSPAD-SGDYECQATN 78

Query: 117 KFGTALSNRIRLQVSKSPLWPKENLDPVVV-QEGAPLTLQCNPPPGLPSPVIFWMSSSME 175
           + G+  S R +L V   P   ++     V    G  LTL+C+   G P P I W+  +  
Sbjct: 79  EVGST-SRRAKLVVYVPPSIREDGRKANVSGMAGQSLTLECDAN-GFPVPEIVWLKDAQ- 135

Query: 176 PITQDKRVSQGHNGDLYFSNV----MLQD--------MQTDYSCNARFHFTHTIQQKNPF 223
            +        G+  DL +  V    +L +        +Q   S         + Q K P+
Sbjct: 136 -LVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQPGRSGRRGAQAGGSAQTKAPW 194

Query: 224 TLKVL------TTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYK- 276
              +       T    +   P  +   G A   + L G D+ L+C  SGVPTP + W K 
Sbjct: 195 XAGLAGFEQFPTPHAFSPPAPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTKD 254

Query: 277 KGGDLPSDK-AKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLD 335
           +   LP     + +   + LRIT     D G Y C+A +  G       +RV A P    
Sbjct: 255 RQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPPTIWG 314

Query: 336 EPKNLILAPGEDG--RLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREV---AGDTIIFR 390
             +   +A  ED   +L+C A G P P + W  +G  L    P   + V    G  +   
Sbjct: 315 SNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALL----PTSTKVVYTRGGRQLQLG 370

Query: 391 DTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRM--LSPRNQLIRVILYNRTRLDCPF 448
             Q S   VY C  SN  G       + V  VPP +     R  +++ +      L+C  
Sbjct: 371 RAQSSDAGVYTCKASNAVGAAEKATRLDVY-VPPTIEGAGGRPYVVKAVAGRPVALECVA 429

Query: 449 FGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQV 508
            G P PTL W   G        +    +   L ++   +   G+Y+CVA++  G+A  Q 
Sbjct: 430 RGHPSPTLSWHHEGLPVAESNESRLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQY 489

Query: 509 RLEVKDPTRIYRMPE-DQVAR-RGTTVQLECRVKHDPSLKLTVSWLKDDEPL--YIGNRM 564
            +EV+ P ++       QV    G  ++L C+    P    T+ WL++  P     G ++
Sbjct: 490 SVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSP--VPTIQWLQNGRPAEELAGVQV 547

Query: 565 KKEDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTVLG 605
             +  +L I  V     G + C A+ E     A+  ++V G
Sbjct: 548 ASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHG 588



 Score =  116 bits (291), Expect = 5e-26
 Identities = 151/596 (25%), Positives = 229/596 (38%), Gaps = 54/596 (9%)

Query: 34  PPTITKQSAKDHIVDPRDNIL-IECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGT 92
           PPTI   +    +    D+++ + CEA+G P P+  W ++     +    +V   R    
Sbjct: 309 PPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGAL--LPTSTKVVYTRGGRQ 366

Query: 93  LVIDFRSGGRPEEYE-GEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQ--EG 149
           L +     GR +  + G Y C A N  G A     RL V   P        P VV+   G
Sbjct: 367 LQL-----GRAQSSDAGVYTCKASNAVGAA-EKATRLDVYVPPTIEGAGGRPYVVKAVAG 420

Query: 150 APLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNA 209
            P+ L+C    G PSP + W    + P+ +        +G +       +     YSC A
Sbjct: 421 RPVALEC-VARGHPSPTLSWHHEGL-PVAESNESRLETDGSVLRLESPGEASSGLYSCVA 478

Query: 210 RFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPT 269
                      +P    VL      +  P  +  +G      ++ G  L L C ASG P 
Sbjct: 479 ----------SSPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIV-GQPLELPCQASGSPV 527

Query: 270 PDIAWYKKGGDLPSDK---AKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVR 326
           P I W + G   P+++    +  +    L I +V  + SG + C A+N+ G+    + V 
Sbjct: 528 PTIQWLQNG--RPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEVEVS 585

Query: 327 VKA--APYWLDEP--------KNLILAPGEDGRLVCRANG-NPKPTV--QWMVNGEPLQS 373
           V    AP  L+ P        ++    P      V R  G +PKP +   W   G     
Sbjct: 586 VHGEWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGE 645

Query: 374 APPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQL 433
               P        +      +    +Y C  +N  G       + VL VPP +      +
Sbjct: 646 PTGIPVAYSLPPPLQIEKVDLRDEGIYTCAATNLAGESKREVALKVL-VPPNI--EPGPV 702

Query: 434 IRVILYNRT-RLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGI 492
            + +L N +  L+C   G P P + WFK  Q  +   G     +   L I+  +  D G 
Sbjct: 703 NKAVLENASVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGS 762

Query: 493 YTCVATNILGKAENQVRLEVKDPTRIYRMPE-DQVARRGTTVQLECRVKHDPSLKLTVSW 551
           Y CVA+N+ G  E +  L V  P RI   P         T V+L C     PS   T+ W
Sbjct: 763 YRCVASNVAGSTELRYGLRVNVPPRITLPPSLPGPVLVNTPVRLTCNATGAPS--PTLMW 820

Query: 552 LKDDEPL----YIGNRMKKEDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTV 603
           LKD  P+      G ++      LT+      D G Y+CVA + + +D     L V
Sbjct: 821 LKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQV 876


>gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens]
          Length = 5065

 Score =  181 bits (460), Expect = 1e-45
 Identities = 165/587 (28%), Positives = 245/587 (41%), Gaps = 47/587 (8%)

Query: 34   PPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTR-NSRFFNIAKDPRVSMRRRSGT 92
            PPTI      D  V     +++ C + G PAP+  W++  ++        RVS    SG 
Sbjct: 3856 PPTIADDQT-DFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLGARGSGYRVSP---SGA 3911

Query: 93   LVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLW-PKENLDPVVVQEGAP 151
            L I    G     + G Y C ARN  G A    + L V  SP+  P  ++   V +E   
Sbjct: 3912 LEI----GQALPIHAGRYTCSARNSAGVA-HKHVFLTVQASPVVKPLPSVVRAVAEEEVL 3966

Query: 152  LTLQCNPPPGLPSPVIFWMSSSMEPITQ-DKRVSQGHNGDLYFSNVMLQDMQTDYSCNAR 210
            L  + +   G+P P I W    +   T    +V  G  G L  ++   +D   +Y C A 
Sbjct: 3967 LPCEAS---GIPRPTITWQKEGLNVATGVSTQVLPG--GQLRIAHASPEDAG-NYLCIA- 4019

Query: 211  FHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTP 270
                     KN     +  TR V +  P     +          G    L C A G P P
Sbjct: 4020 ---------KNSAGSAMGKTRLVVQVPPVI---ENGLPDLSTTEGSHAFLPCKARGSPEP 4067

Query: 271  DIAWYKKGGDLPSDKAKFE-NFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKA 329
            +I W K G  +   + KF    +  L + N+  +D+G Y C A N +G  R  + + +  
Sbjct: 4068 NITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRARRRVHLTILV 4127

Query: 330  APYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIF 389
             P +   P +  L  G+   L C A G+P P + W VN  P+       + +  G T+  
Sbjct: 4128 LPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEGV---SEQDGGSTLQR 4184

Query: 390  RDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFF 449
                      Y C   N  G   A +FV V + P       + L+  +     +LDC   
Sbjct: 4185 AAVSREDSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPV-GGSIQLDCVVR 4243

Query: 450  GSPIPTLRWFKNG---QGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAEN 506
            G P+P + W K+G   +GS+L     H  +NGSL I    ++D G Y C+A N +G A+ 
Sbjct: 4244 GDPVPDIHWIKDGLPLRGSHLR----HQLQNGSLTIHRTERDDAGRYQCLAENEMGVAKK 4299

Query: 507  QVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKK 566
             V L ++        P+D   R G  V L C+   +P+   T+ WL+  +PL    R++ 
Sbjct: 4300 VVILVLQSAPVFQVEPQDMTVRSGDDVALRCQATGEPT--PTIEWLQAGQPLRASRRLRT 4357

Query: 567  -EDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTVLGNCPCSPW 612
              D SL +  V   D G+Y CVA   L    A+A+L V G  P   W
Sbjct: 4358 LPDGSLWLENVETGDAGTYDCVAHNLLGSATARAFLVVRGE-PQGSW 4403



 Score =  162 bits (409), Expect = 1e-39
 Identities = 153/575 (26%), Positives = 241/575 (41%), Gaps = 55/575 (9%)

Query: 28   PMDLTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMR 87
            P  L   P +T        V P +  ++ C   G    +  W R+ R    A   RV+  
Sbjct: 517  PPQLVPAPNVT--------VSPGETAVLSCRVLGEAPYNLTWVRDWRVLP-ASTGRVA-- 565

Query: 88   RRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQ 147
             +   L ++  SG  P +  G YQC A N  G   ++ + L V ++P     +       
Sbjct: 566  -QLADLSLEI-SGIIPTD-GGRYQCVASNANGVTRAS-VWLLVREAPQ-VSIHTSSQHFS 620

Query: 148  EGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSC 207
            +G  + + C+   G P+P I W   S + + +D R+     G L    V  +D   +YSC
Sbjct: 621  QGVEVKVSCSAS-GYPTPHISWSRES-QALQEDSRIHVDAQGTLIIQGVAPEDAG-NYSC 677

Query: 208  NARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMY---PQGTASSQMVLR--GMDLLLEC 262
             A    T+ +              G  + T +  Y   P  +A + +VL   G + +L C
Sbjct: 678  QA----TNEV--------------GTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVC 719

Query: 263  IASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHT 322
             ASGVP P + WY+  G L    A   + +  LRI    E D+G Y C A N++G     
Sbjct: 720  EASGVPPPRVIWYR--GGLEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAE 777

Query: 323  ISVRVKAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMV-NGEPLQ----SAPPN 377
            I + V  AP   + P+++ +  G    L CRA G P PTV W   +G+PL     +   +
Sbjct: 778  IQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGS 837

Query: 378  PNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVI 437
             +R+     + F       +A Y C   N  G + A A + V    P  ++     +RV+
Sbjct: 838  RSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVL 897

Query: 438  LYNRTRLDCPFF-GSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCV 496
                  L C    G P+P   W K+G+     G  + +  +GSL +    +E  G Y+CV
Sbjct: 898  EGQPVSLPCIVLAGRPLPERHWLKDGRPLP-PGSRHSIRADGSLHLDRALQEHAGRYSCV 956

Query: 497  ATNILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDE 556
            ATN  G     V L V+ P RI+      +   G    L C     P+   T++W K+  
Sbjct: 957  ATNTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVASGVPA--PTITWTKETN 1014

Query: 557  PLYI--GNRMKKEDDSLTIFGVAERDQGSYTCVAS 589
             L     +    ++ +L I   + +D G+Y C A+
Sbjct: 1015 ALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTAT 1049



 Score =  156 bits (395), Expect = 5e-38
 Identities = 153/604 (25%), Positives = 252/604 (41%), Gaps = 55/604 (9%)

Query: 35   PTI---TKQSAKDHIVDPRDN-ILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRS 90
            PTI    + SA + +    +N I + CEA   P+P+  W ++   F  +++ ++ +    
Sbjct: 2537 PTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGAPFEASRNIQL-LPGTH 2595

Query: 91   GTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNR-----IRLQVSKSPLWPKENLDPVV 145
            G  +++ +     +E  G+Y C   N+ G A+ N      I   +SK     +  +  V 
Sbjct: 2596 GLQILNAQ-----KEDAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLGEVGVKEVK 2650

Query: 146  VQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDY 205
             +  + LTL+C     +P P I W     +P+T   R+     G L      LQ   T  
Sbjct: 2651 TKVNSTLTLECESW-AVPPPTIRWYKDG-QPVTPSSRLQVLGEGRL------LQIQPTQV 2702

Query: 206  SCNARFHFTHT------------IQQKNPFTLKVLTTRGVAERTPSFMYPQGTASS-QMV 252
            S + R+    T            + Q  P   KV       E        +G  +  + +
Sbjct: 2703 SDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREI 2762

Query: 253  LRGMDLLLECIASGVPTPDIAWYKKGGDLPS-DKAKFENFNKALRITNVSEEDSGEYFCL 311
            +      L C  + +P PD+ WY++   L + D+       + L+I  V  E++G Y C 
Sbjct: 2763 VENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCK 2822

Query: 312  ASNKMGSIRHTISVRVKAAPYWLDEPKNLI----LAPGEDGRLVCRANGNPKPTVQWMVN 367
            ASN++G       + V   P  L + + L+    +       L C A GNP PT+ W+ N
Sbjct: 2823 ASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQN 2882

Query: 368  GEPLQSAPPNPNREVAGDTIIFR--DTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPR 425
            G P     P+P  +V  D  + +    +++  A Y C   N+ G      F   + VPPR
Sbjct: 2883 GLPFS---PSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSA-EKLFTLRVQVPPR 2938

Query: 426  MLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMI 485
            +     + +  IL +   L C     P P + W+K+ Q  +L    + +    +L++   
Sbjct: 2939 IAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGTHTLQLGRA 2998

Query: 486  RKEDQGIYTCVATNILGKAENQVRLEVKDP---TRIYRMPEDQV-ARRGTTVQLECRVKH 541
            R  D G+YTC A N  G+ +  V+L V  P    +  R P+D V  R G    L C    
Sbjct: 2999 RLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCET-- 3056

Query: 542  DPSLKLTVSWLKDDEPLYIGNRMK--KEDDSLTIFGVAERDQGSYTCVASTELDQDLAKA 599
            D   + TV+W KD +PL +  R +  +    L I      D+G Y+C  S    + +   
Sbjct: 3057 DALPEPTVTWYKDGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTF 3116

Query: 600  YLTV 603
             LTV
Sbjct: 3117 TLTV 3120



 Score =  156 bits (394), Expect = 6e-38
 Identities = 152/563 (26%), Positives = 234/563 (41%), Gaps = 70/563 (12%)

Query: 51   DNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYE--- 107
            D  ++ CE    P P+  W ++ +       P V  +R         R G R E  E   
Sbjct: 3048 DKAVLSCETDALPEPTVTWYKDGQ-------PLVLAQRTQA-----LRGGQRLEIQEAQV 3095

Query: 108  ---GEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPS 164
               G Y C   N  G A+     L V   P +     + V    G+PL L C+   G+P+
Sbjct: 3096 SDKGLYSCKVSNVAGEAVRT-FTLTVQVPPTFENPKTETVSQVAGSPLVLTCDVS-GVPA 3153

Query: 165  PVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFT 224
            P + W+   M   +          G L  S +      T Y+C A        + +  F 
Sbjct: 3154 PTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGT-YTCVAE---NTQAEARKDFV 3209

Query: 225  LKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSD 284
            + VL    VA R  S     G A    VL G ++ L+C A G P PD+AW K G  L  D
Sbjct: 3210 VAVL----VAPRIRS----SGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQD 3261

Query: 285  KAKFENF---NKALRITNVSEEDSGEYFCLASNKMG--SIRHTISVRV-KAAPYWLDEPK 338
                  F     +L +  +   D+G Y C+A N  G  +  HT++V V        D   
Sbjct: 3262 MGPHLRFYLDGGSLVLKGLRASDAGAYTCVAHNPAGEDARLHTVNVLVPPTIKQGADGSG 3321

Query: 339  NLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREV---AGDTIIFRDTQIS 395
             L+  PGE   +VC   G+P   V W+ +G PL    P   R +   +G T+     Q++
Sbjct: 3322 TLVSRPGELVTMVCPVRGSPPIHVSWLKDGLPL----PLSQRTLLHGSGHTLRISKVQLA 3377

Query: 396  SRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSP---RNQLIRVILYNRTRLDCPFFGSP 452
               ++ C  ++  G    N F   + VPP +L P   +N ++ V+  +   L C   G P
Sbjct: 3378 DAGIFTCVAASPAGVADRN-FTLQVQVPP-VLEPVEFQNDVV-VVRGSLVELPCEARGVP 3434

Query: 453  IPTLRWFKNGQ---GSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVR 509
            +P + W K+G+     +L+ G        SL+++ +   D G Y+CVA +  G+A    +
Sbjct: 3435 LPLVSWMKDGEPLLSQSLEQG-------PSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQ 3487

Query: 510  LEVKDPTRI--YRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKE 567
            L V +P  I     P +     G  ++L C  +  P   +T  W KD + L      + E
Sbjct: 3488 LTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNIT--WHKDGQAL-----TRLE 3540

Query: 568  DDSLTIFGVAERDQGSYTCVAST 590
            ++S     +  RD G YTC+A +
Sbjct: 3541 NNSRATRVLRVRDAGLYTCLAES 3563



 Score =  152 bits (385), Expect = 7e-37
 Identities = 144/563 (25%), Positives = 229/563 (40%), Gaps = 57/563 (10%)

Query: 55   IECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFA 114
            + C A+GNP P   W+++           V ++ R     + F +    +   G Y+C A
Sbjct: 1139 LNCVAEGNPEPQLSWSKDG----------VVLQGRGPQGSVHFAAIRTSDA--GRYRCEA 1186

Query: 115  RNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQ-EGAPLTLQCNPPPGLPSPVIFWMSS- 172
             N  G   +  + L+V + P W  +    ++ +  G   +L C P  G P P + W    
Sbjct: 1187 SNSAGVD-AWEVELRVLEPPHWGADETSGLLERVAGENASLPC-PARGTPKPQVTWRKGP 1244

Query: 173  SMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRG 232
            S EP+     V+    G L+ ++V   D   DY C A      T ++             
Sbjct: 1245 SSEPLHGQPGVAVLEEGSLFLASVSPAD-SGDYECQATNEVGSTSRRAK----------- 1292

Query: 233  VAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKK-------------GG 279
            +    P  +   G  ++   + G  L LEC A+G P P+I W K              G 
Sbjct: 1293 LVVYVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGW 1352

Query: 280  DLPSDKA---KFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDE 336
            DL   +    +  +  ++L    + E DSG Y C A N+ G+ +    + V   P  L  
Sbjct: 1353 DLGWGQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGA 1412

Query: 337  --PKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQI 394
               + ++   G D  L C  +G P P V+W  + +P+    P+   +  G  +    + +
Sbjct: 1413 GAAQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHV 1472

Query: 395  SSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIP 454
                 YQC   +  G    +  + V   P    S     + V+  +  +L C   G P P
Sbjct: 1473 GDEGRYQCVAFSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTP 1532

Query: 455  TLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKE--DQGIYTCVATNILGKAENQVRLEV 512
             + WFK+G  + L      VY  G  ++++ R +  D G+YTC A+N +G AE   RL+V
Sbjct: 1533 NITWFKDG--ALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDV 1590

Query: 513  KDPTRIY---RMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDD 569
              P  I      P    A  G  V LEC  +  PS   T+SW  +  P+   N  + E D
Sbjct: 1591 YVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPS--PTLSWHHEGLPVAESNESRLETD 1648

Query: 570  S--LTIFGVAERDQGSYTCVAST 590
               L +    E   G Y+CVAS+
Sbjct: 1649 GSVLRLESPGEASSGLYSCVASS 1671



 Score =  151 bits (382), Expect = 1e-36
 Identities = 149/571 (26%), Positives = 230/571 (40%), Gaps = 37/571 (6%)

Query: 34   PPTI---TKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRS 90
            PP I   T++  ++  V+    + ++C A GNP P+  W +N   F+    PR+ +    
Sbjct: 2841 PPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFS--PSPRLQVLEDG 2898

Query: 91   GTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGA 150
              L +              Y C A N+ G+A      L+V   P     +L+ V     +
Sbjct: 2899 QVLQVSTAEVADA----ASYMCVAENQAGSA-EKLFTLRVQVPPRIAGLDLEQVTAILNS 2953

Query: 151  PLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNAR 210
             ++L C+     P+P + W   S      ++         L      L D    Y+C A 
Sbjct: 2954 SVSLPCDVHAH-PNPEVTWYKDSQALSLGEEVFLLPGTHTLQLGRARLSDSGM-YTCEA- 3010

Query: 211  FHFTHTIQQKNPFTLKVLTTRGVAERTPSFMY-PQGTASSQMVLRGMDLLLECIASGVPT 269
                   + +    L VL         P+F   P+G   + +V  G   +L C    +P 
Sbjct: 3011 --LNAAGRDQKLVQLSVLVP-------PAFRQAPRGPQDAVLVRVGDKAVLSCETDALPE 3061

Query: 270  PDIAWYKKGGDLP-SDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVK 328
            P + WYK G  L  + + +     + L I      D G Y C  SN  G    T ++ V+
Sbjct: 3062 PTVTWYKDGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQ 3121

Query: 329  AAPYWLDEPKNLILA--PGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDT 386
              P + + PK   ++   G    L C  +G P PTV W+ +  P++S+  +      G  
Sbjct: 3122 VPPTF-ENPKTETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPVESSAVHGVVSRGGRL 3180

Query: 387  IIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDC 446
             + R  Q +    Y C   N       +  V+VL  P    S   +   V+     RLDC
Sbjct: 3181 QLSR-LQPAQAGTYTCVAENTQAEARKDFVVAVLVAPRIRSSGVAREHHVLEGQEVRLDC 3239

Query: 447  PFFGSPIPTLRWFKNGQGSNLDGGNY--HVYENGSLEIKMIRKEDQGIYTCVATNILGKA 504
               G P P + W K+G     D G +     + GSL +K +R  D G YTCVA N  G+ 
Sbjct: 3240 EADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVAHNPAGED 3299

Query: 505  ENQVRLEVKDPTRIYRMPEDQ---VARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIG 561
                 + V  P  I +  +     V+R G  V + C V+  P +   VSWLKD  PL + 
Sbjct: 3300 ARLHTVNVLVPPTIKQGADGSGTLVSRPGELVTMVCPVRGSPPIH--VSWLKDGLPLPLS 3357

Query: 562  NR--MKKEDDSLTIFGVAERDQGSYTCVAST 590
             R  +     +L I  V   D G +TCVA++
Sbjct: 3358 QRTLLHGSGHTLRISKVQLADAGIFTCVAAS 3388



 Score =  151 bits (381), Expect = 2e-36
 Identities = 150/606 (24%), Positives = 243/606 (40%), Gaps = 58/606 (9%)

Query: 19   LSLGGAIEIPMDLTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNI 78
            L  G  + +P  +T PP++         V     + + C A G P+P+  W ++    + 
Sbjct: 1967 LRYGLRVNVPPRITLPPSLPGP------VLVNTPVRLTCNATGAPSPTLMWLKDGNPVSP 2020

Query: 79   AKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPK 138
            A  P + +      L +   +  R  +  G Y C A +  G    + + LQV   P    
Sbjct: 2021 AGTPGLQVFPGGRVLTL---ASARASD-SGRYSCVAVSAVGEDRQDVV-LQVHMPPSILG 2075

Query: 139  ENLD-PVVVQEGAPLTLQCNPPPGLPSPVIFWMSSS--MEP-----ITQDKRVSQGHNGD 190
            E L+  VV  E   L  Q +    +P PV+ W      +EP     ++ DK + Q    D
Sbjct: 2076 EELNVSVVANESVALECQSH---AMPPPVLSWWKDGRPLEPRPGVHLSADKALLQVDRAD 2132

Query: 191  LYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQ 250
            ++ +          Y+C A     H+ +  N   L V             ++P   + + 
Sbjct: 2133 VWDAG--------HYTCEALNQAGHSEKHYN---LNVWVAP---------VFPLRESHTL 2172

Query: 251  MVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEED---SGE 307
             V  G    L C   GVP P I+W K G  LP + A  ++ +   R+  + +      G 
Sbjct: 2173 TVREGHPTSLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGT 2232

Query: 308  YFCLASNKMGSIRHTISVRVKAAPYWL---DEPKNLILAPGEDGRLVCRANGNPKPTVQW 364
            Y C  SN +G+    + + V   P      + P  + +       L C A G P PTV W
Sbjct: 2233 YTCECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTW 2292

Query: 365  MVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPP 424
              +G+P+  A      +  G ++     Q +    Y C   N  G       +SVL VPP
Sbjct: 2293 ERDGQPV-GAELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVL-VPP 2350

Query: 425  RMLSPRNQL--IRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEI 482
             ++   + L  I   L++   L C   G P P +RWF+  +  +     Y +     L++
Sbjct: 2351 ELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGWMLKM 2410

Query: 483  KMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVAR--RGTTVQLECRVK 540
               +++D G+Y+C+A+N  G+A     +EV  P  I     ++V +   G T  L C V 
Sbjct: 2411 TQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVT 2470

Query: 541  HDPSLKLTVSWLKDDEPLYIGNRMKKEDDS--LTIFGVAERDQGSYTCVASTELDQDLAK 598
              P  KLT  W KD  PL  G+      D   L +        G Y+C+A+  + +    
Sbjct: 2471 GHPQPKLT--WFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKH 2528

Query: 599  AYLTVL 604
              L+VL
Sbjct: 2529 FQLSVL 2534



 Score =  150 bits (380), Expect = 3e-36
 Identities = 144/580 (24%), Positives = 228/580 (39%), Gaps = 37/580 (6%)

Query: 31   LTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRS 90
            L  P   +   A++H V     + ++CEA G P P   W ++         P +      
Sbjct: 3213 LVAPRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDG 3272

Query: 91   GTLVIDFRSGGRPEEYEGEYQCFARNKFG-TALSNRIRLQVSKSPLWPKENLDPVVVQEG 149
            G+LV+     G      G Y C A N  G  A  + + + V  +     +    +V + G
Sbjct: 3273 GSLVLK----GLRASDAGAYTCVAHNPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRPG 3328

Query: 150  APLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNA 209
              +T+ C P  G P   + W+   +      + +  G    L  S V L D    ++C A
Sbjct: 3329 ELVTMVC-PVRGSPPIHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGI-FTCVA 3386

Query: 210  RFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPT 269
                   +  +N FTL+V        + P  + P    +  +V+RG  + L C A GVP 
Sbjct: 3387 A--SPAGVADRN-FTLQV--------QVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPL 3435

Query: 270  PDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKA 329
            P ++W K G  L S   +      +L++  V   DSG Y C+A ++ G  R    + V  
Sbjct: 3436 PLVSWMKDGEPLLSQSLE---QGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVME 3492

Query: 330  APYWLD--EPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTI 387
             P+  D  +P  L L PG    L+C A G P+P + W  +G+ L     N          
Sbjct: 3493 PPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQALTRLENNSRAT------ 3546

Query: 388  IFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRN-QLIRVILYNRTRLDC 446
              R  ++    +Y C   +  G  +  +F   +  PP ++ PR  + +  +   +  L+C
Sbjct: 3547 --RVLRVRDAGLYTCLAESPAG-AIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLVLEC 3603

Query: 447  PFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAEN 506
                 P P + W ++G     D           L+++ +   D G Y+C A N  G    
Sbjct: 3604 SVEAEPAPKITWHRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSV 3663

Query: 507  QVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKK 566
              R+E+     I   P         T  L C+    P+    VSW KD  PL   +   +
Sbjct: 3664 AFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPA--PLVSWRKDRVPLDPRSPRFE 3721

Query: 567  --EDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTVL 604
               + SL I  V  +D G Y C+AS     D     L VL
Sbjct: 3722 ILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVL 3761



 Score =  149 bits (376), Expect = 7e-36
 Identities = 151/580 (26%), Positives = 225/580 (38%), Gaps = 38/580 (6%)

Query: 29   MDLTQPPTITKQSAKDHI-VDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMR 87
            + + +PP I        + + P   + + C+A+G P P+  W ++ +        R+   
Sbjct: 3488 LTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQALT-----RLENN 3542

Query: 88   RRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTA-LSNRIRLQVSKSPLWPKENLDPVVV 146
             R+ T V+  R  G        Y C A +  G    S R+R+Q   + + P+     V +
Sbjct: 3543 SRA-TRVLRVRDAGL-------YTCLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGL 3594

Query: 147  QEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYS 206
              G  L L+C+     P+P I W    +  + +D        G       +      DYS
Sbjct: 3595 APGQ-LVLECSVEAE-PAPKITWHRDGIV-LQEDAHTQFPERGRFLQLQALSTADSGDYS 3651

Query: 207  CNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASG 266
            C AR     T      F +++ T   +    P+            V      LL C A G
Sbjct: 3652 CTARNAAGST---SVAFRVEIHTVPTIRSGPPAVN----------VSVNQTALLPCQADG 3698

Query: 267  VPTPDIAWYKKGGDLPSDKAKFENFNK-ALRITNVSEEDSGEYFCLASNKMGSIRHTISV 325
            VP P ++W K    L     +FE   + +LRI  V  +D+G Y CLASN  GS R    +
Sbjct: 3699 VPAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDL 3758

Query: 326  RVKAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQ-SAPPNPNREVAG 384
            RV   P     P NL L       L C A+G+PKP V W  +G+ L         R +  
Sbjct: 3759 RVLEPPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPS 3818

Query: 385  DTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRL 444
            + ++         A ++C  SNE G      +   + VPP +   +     V +     L
Sbjct: 3819 NALLLTAPGPQDSAQFECVVSNEVGE-AHRLYQVTVHVPPTIADDQTD-FTVTMMAPVVL 3876

Query: 445  DCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKA 504
             C   G P PT+ W K G      G  Y V  +G+LEI        G YTC A N  G A
Sbjct: 3877 TCHSTGIPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGVA 3936

Query: 505  ENQVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIG-NR 563
               V L V+    +  +P    A     V L C     P  + T++W K+   +  G + 
Sbjct: 3937 HKHVFLTVQASPVVKPLPSVVRAVAEEEVLLPCEASGIP--RPTITWQKEGLNVATGVST 3994

Query: 564  MKKEDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTV 603
                   L I   +  D G+Y C+A       + K  L V
Sbjct: 3995 QVLPGGQLRIAHASPEDAGNYLCIAKNSAGSAMGKTRLVV 4034



 Score =  143 bits (361), Expect = 4e-34
 Identities = 154/581 (26%), Positives = 236/581 (40%), Gaps = 47/581 (8%)

Query: 31   LTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRS 90
            LT P  +   +A++ +     ++ ++C   G P P   WT++ R   +   P + ++   
Sbjct: 1404 LTPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTKD-RQPVLPGGPHLQVQEDG 1462

Query: 91   GTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSP-LWPKENLDPVVVQEG 149
              L    R  G     EG YQC A +  G   +   +L+V   P +W       V V E 
Sbjct: 1463 QVL----RITGSHVGDEGRYQCVAFSPAGQQ-ARDFQLRVHAPPTIWGSNETGEVAVMED 1517

Query: 150  APLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNA 209
              + L C    G+P+P I W        T  K V       L        D    Y+C A
Sbjct: 1518 HLVQLLCE-ARGVPTPNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGV-YTCKA 1575

Query: 210  RFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPT 269
                       N        TR      P+     G       + G  + LEC+A G P+
Sbjct: 1576 ----------SNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPS 1625

Query: 270  PDIAWYKKGGDLP---SDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVR 326
            P ++W+ +G  LP   S++++ E     LR+ +  E  SG Y C+AS+  G      SV 
Sbjct: 1626 PTLSWHHEG--LPVAESNESRLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVE 1683

Query: 327  VKAAPYWL--DEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVA- 383
            V+  P  L  +    +    G+   L C+A+G+P PT+QW+ NG P +        +VA 
Sbjct: 1684 VQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGRPAEEL---AGVQVAS 1740

Query: 384  -GDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLD--VPPRMLSPRNQLIRVILYN 440
             G T+     ++    ++ C  +NE G   A   VSV     P  +  P  Q      ++
Sbjct: 1741 QGTTLHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHH 1800

Query: 441  RT---RLDCP----FFGSPIPTL--RWFKNGQGSNLDGGNYHVYE-NGSLEIKMIRKEDQ 490
             +     D P    +   P P L   W   G       G    Y     L+I+ +   D+
Sbjct: 1801 SSFPAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLPPPLQIEKVDLRDE 1860

Query: 491  GIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVS 550
            GIYTC ATN+ G+++ +V L+V  P  I   P ++      +V LEC     P     VS
Sbjct: 1861 GIYTCAATNLAGESKREVALKVLVPPNIEPGPVNKAVLENASVTLECLASGVP--PPDVS 1918

Query: 551  WLKDDEPL--YIGNRMKKEDDSLTIFGVAERDQGSYTCVAS 589
            W K  +P+  ++G  +  +   L I      D GSY CVAS
Sbjct: 1919 WFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVAS 1959



 Score =  143 bits (360), Expect = 5e-34
 Identities = 161/639 (25%), Positives = 241/639 (37%), Gaps = 105/639 (16%)

Query: 32   TQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSG 91
            T PP+++  +A   +    + +L+ CEA G P P   W R      +A +   S +    
Sbjct: 695  TDPPSVSAVNAVVLVAVGEEAVLV-CEASGVPPPRVIWYRGGLEMILAPEGSSSGK---- 749

Query: 92   TLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAP 151
                  R     E   G Y C A N+ G A S  I+L V  +P   +   D V V+ G  
Sbjct: 750  -----LRIPAAQERDAGTYTCRAVNELGDA-SAEIQLAVGHAPQLTELPRD-VTVELGRS 802

Query: 152  LTLQCNPPPGLPSPVIFWMSSSMEPIT------QDKRVSQGHNGDLYFSNVMLQDMQTDY 205
              L C    G P P + W     +P+       +  R  Q  +G L+F +V  +D Q  Y
Sbjct: 803  ALLACRAT-GRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPED-QAPY 860

Query: 206  SCNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIA- 264
             C AR  F      K     +++ T     +  S      +A +  VL G  + L CI  
Sbjct: 861  VCEARNVFG-----KVQAEARLIVTGHAPPQIAS------SAPTVRVLEGQPVSLPCIVL 909

Query: 265  SGVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTIS 324
            +G P P+  W K G  LP         + +L +    +E +G Y C+A+N  GS    + 
Sbjct: 910  AGRPLPERHWLKDGRPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVE 969

Query: 325  VRVKAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAG 384
            + V+  P       + I   G    L C A+G P PT+ W      L S  P+ N    G
Sbjct: 970  LVVQVPPRIHPTATHHITNEGVPASLPCVASGVPAPTITWTKETNALTSRGPHYNVSKEG 1029

Query: 385  DTII----------------------------------------------------FRDT 392
              +I                                                        
Sbjct: 1030 TLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNRLALSKYVWEEYGLLPSGSLRLAQV 1089

Query: 393  QISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSP 452
            Q+     Y+C  SN  G   ++ +V  + VPP+ + P  ++++V++     L+C   G+P
Sbjct: 1090 QVGDSGHYECTASNPAG-SASHRYVLGVQVPPQ-VQPGPRVLKVLVGEALDLNCVAEGNP 1147

Query: 453  IPTLRWFKNG---QGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVR 509
             P L W K+G   QG             GS+    IR  D G Y C A+N  G    +V 
Sbjct: 1148 EPQLSWSKDGVVLQGRG---------PQGSVHFAAIRTSDAGRYRCEASNSAGVDAWEVE 1198

Query: 510  LEVKDPTRIYRMPEDQVARR--GTTVQLECRVKHDPSLKLTVSWLK--DDEPLYIGNRMK 565
            L V +P          +  R  G    L C  +  P  K  V+W K    EPL+    + 
Sbjct: 1199 LRVLEPPHWGADETSGLLERVAGENASLPCPARGTP--KPQVTWRKGPSSEPLHGQPGVA 1256

Query: 566  -KEDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTV 603
              E+ SL +  V+  D G Y C A+ E+     +A L V
Sbjct: 1257 VLEEGSLFLASVSPADSGDYECQATNEVGSTSRRAKLVV 1295



 Score =  143 bits (360), Expect = 5e-34
 Identities = 145/562 (25%), Positives = 224/562 (39%), Gaps = 45/562 (8%)

Query: 55   IECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFA 114
            + CE +G P P   W ++ +     +   +      G L+     G      EG Y C  
Sbjct: 2182 LSCECRGVPFPKISWRKDGQPLP-GEGAGLQHVSAVGRLLY---LGQAQLAQEGTYTCEC 2237

Query: 115  RNKFGTALSNRIRLQVSKSP--LWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSS 172
             N  G + S  ++L+V   P    P+E    V V +    TL+CN   G P P + W   
Sbjct: 2238 SNVVGNS-SQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNAT-GKPPPTVTWERD 2295

Query: 173  SMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRG 232
              +P+  +  +   + G               YSC A  +     ++K  F L VL    
Sbjct: 2296 G-QPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAE-NLAGRAERK--FELSVLVP-- 2349

Query: 233  VAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDL-PSDKAKFENF 291
                 P  +      ++        L L C A G+P P I W++    + P +       
Sbjct: 2350 -----PELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAG 2404

Query: 292  NKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILA--PGEDGR 349
               L++T   E+DSG Y CLASN+ G  R   SV V   P   +E    ++    G+   
Sbjct: 2405 GWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAH 2464

Query: 350  LVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQ--ISSRAVYQCNTSNE 407
            L+C   G+P+P + W  +G PL     +    ++ D ++ +  Q  +SS   Y C  +N 
Sbjct: 2465 LMCNVTGHPQPKLTWFKDGRPLARGDAH---HISPDGVLLQVLQANLSSAGHYSCIAANA 2521

Query: 408  HGYLLANAFVSVLDVPPRMLSPRNQL---IRVILYNRTRLDCPFFGSPIPTLRWFKNGQG 464
             G    +  +SVL  P  +    +     + V + N   L C     P P + W K+G  
Sbjct: 2522 VGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGAP 2581

Query: 465  SNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPED 524
                     +     L+I   +KED G YTCV TN LG+A     +EV  P  I +  +D
Sbjct: 2582 FEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSISK--DD 2639

Query: 525  QVARRG---------TTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMK--KEDDSLTI 573
             +   G         +T+ LEC     P    T+ W KD +P+   +R++   E   L I
Sbjct: 2640 PLGEVGVKEVKTKVNSTLTLECESWAVP--PPTIRWYKDGQPVTPSSRLQVLGEGRLLQI 2697

Query: 574  FGVAERDQGSYTCVASTELDQD 595
                  D G Y CVA+    +D
Sbjct: 2698 QPTQVSDSGRYLCVATNVAGED 2719



 Score =  141 bits (355), Expect = 2e-33
 Identities = 150/598 (25%), Positives = 241/598 (40%), Gaps = 84/598 (14%)

Query: 55   IECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFA 114
            +EC A G P P+  W R+ +   +  +  + ++ +  +L ++         + G Y C A
Sbjct: 2278 LECNATGKPPPTVTWERDGQ--PVGAELGLQLQNQGQSLHVERAQAA----HTGRYSCVA 2331

Query: 115  RNKFGTALSNRIRLQVSKSPLWPKE---NLDPVVVQEGA---PLTLQCNPPPGLPSPVIF 168
             N     L+ R   +   S L P E   +LDP+     A   PLTL C    G+P P I 
Sbjct: 2332 EN-----LAGRAERKFELSVLVPPELIGDLDPLTNITAALHSPLTLLCEAM-GIPPPAIR 2385

Query: 169  WMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTD------YSCNARFHFTHTIQQKNP 222
            W     EP      VS G +  L     ML+  QT       YSC A        + +  
Sbjct: 2386 WFRGE-EP------VSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLAS---NEAGEARRN 2435

Query: 223  FTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLP 282
            F+++VL         P  +  +       VL G    L C  +G P P + W+K G  L 
Sbjct: 2436 FSVEVLV--------PPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLA 2487

Query: 283  -SDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWL-----DE 336
              D          L++   +   +G Y C+A+N +G       + V  AP  L       
Sbjct: 2488 RGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPTILGGAEDSA 2547

Query: 337  PKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDT--IIFRDTQI 394
             + + +       L+C A   P P + WM +G P +++    N ++   T  +   + Q 
Sbjct: 2548 DEEVTVTVNNPISLICEALAFPSPNITWMKDGAPFEASR---NIQLLPGTHGLQILNAQK 2604

Query: 395  SSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLS--PRNQL----IRVILYNRTRLDCPF 448
                 Y C  +NE G  + N  V VL +PP +    P  ++    ++  + +   L+C  
Sbjct: 2605 EDAGQYTCVVTNELGEAVKNYHVEVL-IPPSISKDDPLGEVGVKEVKTKVNSTLTLECES 2663

Query: 449  FGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQV 508
            +  P PT+RW+K+GQ          + E   L+I+  +  D G Y CVATN+ G+ +   
Sbjct: 2664 WAVPPPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDF 2723

Query: 509  RLEVKDPTRIYR----------MPEDQVARRGTT----------VQLECRVKHDPSLKLT 548
             + ++ P    +          +  ++ AR G T            L C     P   LT
Sbjct: 2724 NVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLT 2783

Query: 549  VSWLKDDEPLYIGNRMK--KEDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTVL 604
              W ++D+PL  G+ +   +    L I  V   + G Y+C AS E+ +D     L VL
Sbjct: 2784 --WYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVGEDWLHYELLVL 2839



 Score =  140 bits (352), Expect = 4e-33
 Identities = 160/647 (24%), Positives = 245/647 (37%), Gaps = 94/647 (14%)

Query: 34   PPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTL 93
            PP I   +    +++ +   L      G P P  HW ++ R   +    R S+R   G+L
Sbjct: 884  PPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGR--PLPPGSRHSIRA-DGSL 940

Query: 94   VIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPV----VVQEG 149
             +D       +E+ G Y C A N  G+   + + L V   P      + P     +  EG
Sbjct: 941  HLDRAL----QEHAGRYSCVATNTAGSQHRD-VELVVQVPP-----RIHPTATHHITNEG 990

Query: 150  APLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNA 209
             P +L C    G+P+P I W   +    ++    +    G L  +    QD    Y C A
Sbjct: 991  VPASLPC-VASGVPAPTITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGA-YVCTA 1048

Query: 210  RFHFTHTIQQKNPFTLKVLTTRGVAER---TPSFMY-------------------PQGTA 247
                  + Q+      ++  ++ V E     PS                      P G+A
Sbjct: 1049 TNTVGFSSQEMRLSVNRLALSKYVWEEYGLLPSGSLRLAQVQVGDSGHYECTASNPAGSA 1108

Query: 248  SSQMVLR------------------GMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFE 289
            S + VL                   G  L L C+A G P P ++W K G  L     +  
Sbjct: 1109 SHRYVLGVQVPPQVQPGPRVLKVLVGEALDLNCVAEGNPEPQLSWSKDGVVLQGRGPQGS 1168

Query: 290  NFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYW-LDEPKNLI-LAPGED 347
                A+R +     D+G Y C ASN  G     + +RV   P+W  DE   L+    GE+
Sbjct: 1169 VHFAAIRTS-----DAGRYRCEASNSAGVDAWEVELRVLEPPHWGADETSGLLERVAGEN 1223

Query: 348  GRLVCRANGNPKPTVQWM--VNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTS 405
              L C A G PKP V W    + EPL   P     E    ++       +    Y+C  +
Sbjct: 1224 ASLPCPARGTPKPQVTWRKGPSSEPLHGQPGVAVLEEG--SLFLASVSPADSGDYECQAT 1281

Query: 406  NEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQ-- 463
            NE G     A + V   P      R   +  +      L+C   G P+P + W K+ Q  
Sbjct: 1282 NEVGSTSRRAKLVVYVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLV 1341

Query: 464  -------------GSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRL 510
                         G    GG+  + E  SL    I++ D G+Y+C A N  G A+    L
Sbjct: 1342 GVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAGTAQRDFHL 1401

Query: 511  EVKDPTRIY--RMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGN---RMK 565
             V  P  +      ++ +   G  V+L+C     P+ +  V W KD +P+  G    +++
Sbjct: 1402 LVLTPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQ--VEWTKDRQPVLPGGPHLQVQ 1459

Query: 566  KEDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTVLGNCPCSPW 612
            ++   L I G    D+G Y CVA +   Q      L V  + P + W
Sbjct: 1460 EDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRV--HAPPTIW 1504



 Score =  137 bits (344), Expect = 4e-32
 Identities = 147/586 (25%), Positives = 234/586 (39%), Gaps = 54/586 (9%)

Query: 26   EIPMDLTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVS 85
            E+ + +  PP I        +++   ++ +EC A G P P   W +  +  +      VS
Sbjct: 1877 EVALKVLVPPNIEPGPVNKAVLE-NASVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVS 1935

Query: 86   MRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFG-TALSNRIRLQVSKSPLWPKENLDPV 144
            +  R    V+        +   G Y+C A N  G T L   +R+ V      P     PV
Sbjct: 1936 VDGR----VLRIEQAQLSD--AGSYRCVASNVAGSTELRYGLRVNVPPRITLPPSLPGPV 1989

Query: 145  VVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPI----TQDKRVSQGHNGDLYFSNVMLQD 200
            +V    P+ L CN   G PSP + W+     P+    T   +V  G    L  ++    D
Sbjct: 1990 LV--NTPVRLTCN-ATGAPSPTLMWLKDG-NPVSPAGTPGLQVFPG-GRVLTLASARASD 2044

Query: 201  MQTDYSCNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLL 260
                YSC A    +   + +    L+V          PS +   G   +  V+    + L
Sbjct: 2045 -SGRYSCVA---VSAVGEDRQDVVLQV-------HMPPSIL---GEELNVSVVANESVAL 2090

Query: 261  ECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKA-LRITNVSEEDSGEYFCLASNKMGSI 319
            EC +  +P P ++W+K G  L        + +KA L++      D+G Y C A N+ G  
Sbjct: 2091 ECQSHAMPPPVLSWWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGHS 2150

Query: 320  RHTISVRVKAAPYW-LDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPN- 377
                ++ V  AP + L E   L +  G    L C   G P P + W  +G+PL       
Sbjct: 2151 EKHYNLNVWVAPVFPLRESHTLTVREGHPTSLSCECRGVPFPKISWRKDGQPLPGEGAGL 2210

Query: 378  PNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRN--QLIR 435
             +    G  +     Q++    Y C  SN  G    +  + V  VPP++  PR     + 
Sbjct: 2211 QHVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEV-HVPPQIAGPREPPTQVS 2269

Query: 436  VILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTC 495
            V+      L+C   G P PT+ W ++GQ    + G     +  SL ++  +    G Y+C
Sbjct: 2270 VVQDGVATLECNATGKPPPTVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSC 2329

Query: 496  VATNILGKAENQVRLEVKDPTRIYRMPE---DQVARRGTTVQLECRVKHDPSLKLTVSWL 552
            VA N+ G+AE +  L V  P  +    +   +  A   + + L C     P     + W 
Sbjct: 2330 VAENLAGRAERKFELSVLVPPELIGDLDPLTNITAALHSPLTLLCEAMGIP--PPAIRWF 2387

Query: 553  KDDEPLYIGNRMKKEDDSLTIFG-------VAERDQGSYTCVASTE 591
            + +EP+  G     ED  L   G         E+D G Y+C+AS E
Sbjct: 2388 RGEEPVSPG-----EDTYLLAGGWMLKMTQTQEQDSGLYSCLASNE 2428



 Score =  135 bits (341), Expect = 8e-32
 Identities = 125/495 (25%), Positives = 203/495 (41%), Gaps = 31/495 (6%)

Query: 34   PPTITKQSAKDHIVDPR-DNILIECEAKGNPAPSFHWTRNSRFFNIAKDPR-----VSMR 87
            PP+I +   K ++      ++ +EC+A G P P   W ++++   +          +   
Sbjct: 1298 PPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWG 1357

Query: 88   RRSGTLVIDF-RSGGRPEEYEGE---YQCFARNKFGTALSNRIRLQVSKSPLWPKENLDP 143
            +  G  ++D  +S   P   EG+   Y C A N+ GTA  +   L ++   +        
Sbjct: 1358 QVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGAGAAQE 1417

Query: 144  VVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQT 203
            V+   GA + LQC    G+P+P + W       +     +    +G +          + 
Sbjct: 1418 VLGLAGADVELQCWTS-GVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEG 1476

Query: 204  DYSCNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECI 263
             Y C A   F+   QQ   F L+V          P  ++         V+    + L C 
Sbjct: 1477 RYQCVA---FSPAGQQARDFQLRV--------HAPPTIWGSNETGEVAVMEDHLVQLLCE 1525

Query: 264  ASGVPTPDIAWYKKGGDLP-SDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHT 322
            A GVPTP+I W+K G  LP S K  +    + L++      D+G Y C ASN +G+    
Sbjct: 1526 ARGVPTPNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKA 1585

Query: 323  ISVRVKAAPYWLD---EPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPN 379
              + V   P        P  +    G    L C A G+P PT+ W   G P+  A  N +
Sbjct: 1586 TRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEGLPV--AESNES 1643

Query: 380  R-EVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQ-LIRVI 437
            R E  G  +       +S  +Y C  S+  G  +    V V  VPP++L       +  I
Sbjct: 1644 RLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEV-QVPPQLLVAEGLGQVTTI 1702

Query: 438  LYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVA 497
            +     L C   GSP+PT++W +NG+ +    G     +  +L I  +  +  G++ C A
Sbjct: 1703 VGQPLELPCQASGSPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQA 1762

Query: 498  TNILGKAENQVRLEV 512
            TN  G A  +V + V
Sbjct: 1763 TNEAGTAGAEVEVSV 1777



 Score =  134 bits (337), Expect = 2e-31
 Identities = 154/610 (25%), Positives = 246/610 (40%), Gaps = 55/610 (9%)

Query: 29   MDLTQPPTITKQSAKDHI-VDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMR 87
            +++  PP+I  +  ++ I V       + C   G+P P   W ++ R         +S  
Sbjct: 2438 VEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHISP- 2496

Query: 88   RRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPL---WPKENLDP- 143
               G L+   ++        G Y C A N  G   +   +L V  +P      +++ D  
Sbjct: 2497 --DGVLLQVLQAN---LSSAGHYSCIAANAVGEK-TKHFQLSVLLAPTILGGAEDSADEE 2550

Query: 144  VVVQEGAPLTLQCNPPPGLPSPVIFWMSSSME-PITQDKRVSQGHNGDLYFSNVMLQDMQ 202
            V V    P++L C      PSP I WM        +++ ++  G +G L   N   +D  
Sbjct: 2551 VTVTVNNPISLICEAL-AFPSPNITWMKDGAPFEASRNIQLLPGTHG-LQILNAQKEDAG 2608

Query: 203  TDYSCNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLEC 262
              Y+C         ++    + ++VL    +++  P          +++      L LEC
Sbjct: 2609 -QYTCVVTNELGEAVKN---YHVEVLIPPSISKDDPLGEVGVKEVKTKV---NSTLTLEC 2661

Query: 263  IASGVPTPDIAWYKKGGDL-PSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRH 321
             +  VP P I WYK G  + PS + +     + L+I      DSG Y C+A+N  G    
Sbjct: 2662 ESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQ 2721

Query: 322  TISVRVKAAPYWLD----EPKNLILAPGEDGR----------------LVCRANGNPKPT 361
              +V ++  P +           IL+  E+ R                L C  N  P P 
Sbjct: 2722 DFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPD 2781

Query: 362  VQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLD 421
            + W    +PL SA    +    G  +     +  +   Y C  SNE G    +  + VL 
Sbjct: 2782 LTWYREDQPL-SAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVGEDWLHYELLVL- 2839

Query: 422  VPPRMLSPRNQLIRVILYNRTR---LDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENG 478
             PP +L    +L+  +  N +    L CP  G+P+PT+ W +NG   +       V E+G
Sbjct: 2840 TPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFS-PSPRLQVLEDG 2898

Query: 479  S-LEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQV-ARRGTTVQLE 536
              L++      D   Y CVA N  G AE    L V+ P RI  +  +QV A   ++V L 
Sbjct: 2899 QVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQVPPRIAGLDLEQVTAILNSSVSLP 2958

Query: 537  CRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTI-FGVAE-RDQGSYTCVASTELDQ 594
            C V   P+ ++T  W KD + L +G  +     + T+  G A   D G YTC A     +
Sbjct: 2959 CDVHAHPNPEVT--WYKDSQALSLGEEVFLLPGTHTLQLGRARLSDSGMYTCEALNAAGR 3016

Query: 595  DLAKAYLTVL 604
            D     L+VL
Sbjct: 3017 DQKLVQLSVL 3026



 Score =  132 bits (332), Expect = 9e-31
 Identities = 147/571 (25%), Positives = 219/571 (38%), Gaps = 77/571 (13%)

Query: 55   IECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFA 114
            + C+A G+P P+  W +N R     +   V +  +  TL ID        ++ G + C A
Sbjct: 1709 LPCQASGSPVPTIQWLQNGR--PAEELAGVQVASQGTTLHIDHVE----LDHSGLFACQA 1762

Query: 115  RNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQ------EGAPLTLQCNPP--------- 159
             N+ GTA +    ++VS    W    L+  + Q        +     C+PP         
Sbjct: 1763 TNEAGTAGAE---VEVSVHGEWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGAHP 1819

Query: 160  -----PGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFT 214
                  G  SP   W   +  P      V+      L    V L+D +  Y+C A     
Sbjct: 1820 KPPLVEGWCSPGSLWGEPTGIP------VAYSLPPPLQIEKVDLRD-EGIYTCAAT---N 1869

Query: 215  HTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAW 274
               + K    LKVL    +          +    ++ VL    + LEC+ASGVP PD++W
Sbjct: 1870 LAGESKREVALKVLVPPNI----------EPGPVNKAVLENASVTLECLASGVPPPDVSW 1919

Query: 275  YKKGGDLPSDKAKFENFN-KALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYW 333
            +K    + S      + + + LRI      D+G Y C+ASN  GS      +RV      
Sbjct: 1920 FKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRYGLRVNV---- 1975

Query: 334  LDEPKNLILAPGEDG--------RLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREV--A 383
               P  + L P   G        RL C A G P PT+ W+ +G P+  A   P  +V   
Sbjct: 1976 ---PPRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPA-GTPGLQVFPG 2031

Query: 384  GDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTR 443
            G  +     + S    Y C   +  G    +  + V  +PP +L      + V+      
Sbjct: 2032 GRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQV-HMPPSILGEELN-VSVVANESVA 2089

Query: 444  LDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGK 503
            L+C     P P L W+K+G+      G +   +   L++      D G YTC A N  G 
Sbjct: 2090 LECQSHAMPPPVLSWWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGH 2149

Query: 504  AENQVRLEV-KDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPL---Y 559
            +E    L V   P    R       R G    L C  +  P  K  +SW KD +PL    
Sbjct: 2150 SEKHYNLNVWVAPVFPLRESHTLTVREGHPTSLSCECRGVPFPK--ISWRKDGQPLPGEG 2207

Query: 560  IGNRMKKEDDSLTIFGVAE-RDQGSYTCVAS 589
             G +       L   G A+   +G+YTC  S
Sbjct: 2208 AGLQHVSAVGRLLYLGQAQLAQEGTYTCECS 2238



 Score =  132 bits (331), Expect = 1e-30
 Identities = 151/582 (25%), Positives = 240/582 (41%), Gaps = 51/582 (8%)

Query: 51   DNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEY 110
            +N  + C A+G P P   W +      +   P V++    G+L   F +   P +  G+Y
Sbjct: 1222 ENASLPCPARGTPKPQVTWRKGPSSEPLHGQPGVAVLEE-GSL---FLASVSPAD-SGDY 1276

Query: 111  QCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVV-QEGAPLTLQCNPPPGLPSPVIFW 169
            +C A N+ G+  S R +L V   P   ++     V    G  LTL+C+   G P P I W
Sbjct: 1277 ECQATNEVGST-SRRAKLVVYVPPSIREDGRKANVSGMAGQSLTLECDAN-GFPVPEIVW 1334

Query: 170  MSSSMEPITQDKRVSQGHNGDLYFSNV----MLQDMQTDYSCNARFHFTHTIQQKNP--F 223
            +  +   +        G+  DL +  V    +L + Q+        HF   IQ+ +   +
Sbjct: 1335 LKDAQ--LVGVPLGWAGYGWDLGWGQVGGHRLLDEGQS-------LHFPR-IQEGDSGLY 1384

Query: 224  TLKVLTTRGVAER-------TPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYK 276
            + +     G A+R       TP  +   G A   + L G D+ L+C  SGVPTP + W K
Sbjct: 1385 SCRAENQAGTAQRDFHLLVLTPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTK 1444

Query: 277  -KGGDLPSDK-AKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWL 334
             +   LP     + +   + LRIT     D G Y C+A +  G       +RV A P   
Sbjct: 1445 DRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPPTIW 1504

Query: 335  DEPKNLILAPGEDG--RLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREV---AGDTIIF 389
               +   +A  ED   +L+C A G P P + W  +G  L    P   + V    G  +  
Sbjct: 1505 GSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALL----PTSTKVVYTRGGRQLQL 1560

Query: 390  RDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRM--LSPRNQLIRVILYNRTRLDCP 447
               Q S   VY C  SN  G       + V  VPP +     R  +++ +      L+C 
Sbjct: 1561 GRAQSSDAGVYTCKASNAVGAAEKATRLDVY-VPPTIEGAGGRPYVVKAVAGRPVALECV 1619

Query: 448  FFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQ 507
              G P PTL W   G        +    +   L ++   +   G+Y+CVA++  G+A  Q
Sbjct: 1620 ARGHPSPTLSWHHEGLPVAESNESRLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQ 1679

Query: 508  VRLEVKDPTRIYRMPE-DQVAR-RGTTVQLECRVKHDPSLKLTVSWLKDDEPL--YIGNR 563
              +EV+ P ++       QV    G  ++L C+    P    T+ WL++  P     G +
Sbjct: 1680 YSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSP--VPTIQWLQNGRPAEELAGVQ 1737

Query: 564  MKKEDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTVLG 605
            +  +  +L I  V     G + C A+ E     A+  ++V G
Sbjct: 1738 VASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHG 1779



 Score =  121 bits (303), Expect = 2e-27
 Identities = 99/373 (26%), Positives = 159/373 (42%), Gaps = 22/373 (5%)

Query: 247 ASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENF-NKALRITNVSEEDS 305
           A +  V  G   +L C   G    ++ W +    LP+   +     + +L I+ +   D 
Sbjct: 523 APNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDG 582

Query: 306 GEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWM 365
           G Y C+ASN  G  R ++ + V+ AP       +   + G + ++ C A+G P P + W 
Sbjct: 583 GRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWS 642

Query: 366 VNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPR 425
              + LQ    +     A  T+I +         Y C  +NE G       V++    P 
Sbjct: 643 RESQALQE--DSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVG--TDQETVTLYYTDPP 698

Query: 426 MLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNL--DGGNYHVYENGSLEIK 483
            +S  N ++ V +     L C   G P P + W++ G    L  +G +     +G L I 
Sbjct: 699 SVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSS-----SGKLRIP 753

Query: 484 MIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDP 543
             ++ D G YTC A N LG A  +++L V    ++  +P D     G +  L CR    P
Sbjct: 754 AAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRP 813

Query: 544 SLKLTVSWLKDD-EPLYI------GNRMKKEDDSLTIF-GVAERDQGSYTCVASTELDQD 595
               TV+W + D +PL +      G+R ++ D  +  F  VA  DQ  Y C A     + 
Sbjct: 814 PP--TVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKV 871

Query: 596 LAKAYLTVLGNCP 608
            A+A L V G+ P
Sbjct: 872 QAEARLIVTGHAP 884



 Score =  120 bits (301), Expect = 4e-27
 Identities = 107/413 (25%), Positives = 180/413 (43%), Gaps = 34/413 (8%)

Query: 16   LCLL--SLGGAIEIPMDLTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNS 73
            LC+   S G A+     + Q P + +    D       +  + C+A+G+P P+  W ++ 
Sbjct: 4016 LCIAKNSAGSAMGKTRLVVQVPPVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDG 4075

Query: 74   RFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKS 133
            +  + A+       + SG L++    G    +  G Y C A N  G A   R+ L +   
Sbjct: 4076 QPVSGAEGKFTI--QPSGELLVKNLEG----QDAGTYTCTAENAVGRA-RRRVHLTILVL 4128

Query: 134  PLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYF 193
            P++     D  + + G  L L+C    G P+P I W  +   P+T+   VS+   G    
Sbjct: 4129 PVFTTLPGDRSL-RLGDRLWLRC-AARGSPTPRIGWTVND-RPVTEG--VSEQDGGSTLQ 4183

Query: 194  SNVMLQDMQTDYSCNA--RFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQM 251
               + ++    Y C A  R   T  +   +     VL               QG A S +
Sbjct: 4184 RAAVSREDSGTYVCWAENRVGRTQAVSFVHVKEAPVL---------------QGEAFSYL 4228

Query: 252  VLR-GMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFC 310
            V   G  + L+C+  G P PDI W K G  L     + +  N +L I     +D+G Y C
Sbjct: 4229 VEPVGGSIQLDCVVRGDPVPDIHWIKDGLPLRGSHLRHQLQNGSLTIHRTERDDAGRYQC 4288

Query: 311  LASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEP 370
            LA N+MG  +  + + +++AP +  EP+++ +  G+D  L C+A G P PT++W+  G+P
Sbjct: 4289 LAENEMGVAKKVVILVLQSAPVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQP 4348

Query: 371  LQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVP 423
            L+++     R +   ++   + +      Y C   N  G   A AF+ V   P
Sbjct: 4349 LRAS--RRLRTLPDGSLWLENVETGDAGTYDCVAHNLLGSATARAFLVVRGEP 4399



 Score =  115 bits (288), Expect = 1e-25
 Identities = 125/494 (25%), Positives = 193/494 (39%), Gaps = 50/494 (10%)

Query: 33   QPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGT 92
            + P ++  ++  H     + + + C A G P P   W+R S+   + +D R+ +  + GT
Sbjct: 606  EAPQVSIHTSSQHFSQGVE-VKVSCSASGYPTPHISWSRESQA--LQEDSRIHVDAQ-GT 661

Query: 93   LVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPL 152
            L+I    G  PE+  G Y C A N+ GT     + L  +  P     N   V+V  G   
Sbjct: 662  LIIQ---GVAPED-AGNYSCQATNEVGTD-QETVTLYYTDPPSVSAVNA-VVLVAVGEEA 715

Query: 153  TLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFH 212
             L C    G+P P + W    +E I   +  S   +G L       +D  T Y+C A   
Sbjct: 716  VLVCEAS-GVPPPRVIWYRGGLEMILAPEGSS---SGKLRIPAAQERDAGT-YTCRA--- 767

Query: 213  FTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDI 272
                + +    + ++    G A +      P+       V  G   LL C A+G P P +
Sbjct: 768  ----VNELGDASAEIQLAVGHAPQLTEL--PRDVT----VELGRSALLACRATGRPPPTV 817

Query: 273  AWYKKGGD-------LPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISV 325
             W +  G                +  +  L   +V+ ED   Y C A N  G ++    +
Sbjct: 818  TWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARL 877

Query: 326  RVK--AAPYWLDEPKNLILAPGEDGRLVCRA-NGNPKPTVQWMVNGEPLQSAPPNPNREV 382
             V   A P        + +  G+   L C    G P P   W+ +G PL   PP     +
Sbjct: 878  IVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPL---PPGSRHSI 934

Query: 383  AGDTIIFRDTQISSRAV-YQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNR 441
              D  +  D  +   A  Y C  +N  G    +  + V+ VPPR+       I     N 
Sbjct: 935  RADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVEL-VVQVPPRIHPTATHHIT----NE 989

Query: 442  ---TRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVAT 498
                 L C   G P PT+ W K        G +Y+V + G+L I     +D G Y C AT
Sbjct: 990  GVPASLPCVASGVPAPTITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTAT 1049

Query: 499  NILGKAENQVRLEV 512
            N +G +  ++RL V
Sbjct: 1050 NTVGFSSQEMRLSV 1063



 Score = 95.1 bits (235), Expect = 2e-19
 Identities = 84/322 (26%), Positives = 132/322 (40%), Gaps = 12/322 (3%)

Query: 289 ENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDG 348
           E+ N +  I   S+ + G Y C A ++ G+ R    + V   P  L    N+ ++PGE  
Sbjct: 475 ESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETA 534

Query: 349 RLVCRANGNPKPTVQWMVNGEPLQSAPPNPNR--EVAGDTIIFRDTQISSRAVYQCNTSN 406
            L CR  G     + W+ +   L   P +  R  ++A  ++       +    YQC  SN
Sbjct: 535 VLSCRVLGEAPYNLTWVRDWRVL---PASTGRVAQLADLSLEISGIIPTDGGRYQCVASN 591

Query: 407 EHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSN 466
            +G   A+ ++ V + P   +   +Q     +    ++ C   G P P + W +  Q   
Sbjct: 592 ANGVTRASVWLLVREAPQVSIHTSSQHFSQGV--EVKVSCSASGYPTPHISWSRESQALQ 649

Query: 467 LDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQV 526
            D    HV   G+L I+ +  ED G Y+C ATN +G  +  V L   DP  +  +    +
Sbjct: 650 ED-SRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVL 708

Query: 527 ARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAERDQGSYTC 586
              G    L C     P  +  V W +    + +          L I    ERD G+YTC
Sbjct: 709 VAVGEEAVLVCEASGVPPPR--VIWYRGGLEMILAPE-GSSSGKLRIPAAQERDAGTYTC 765

Query: 587 VASTELDQDLAKAYLTVLGNCP 608
            A  EL    A+  L V G+ P
Sbjct: 766 RAVNELGDASAEIQLAV-GHAP 786



 Score = 54.3 bits (129), Expect = 3e-07
 Identities = 43/155 (27%), Positives = 62/155 (40%), Gaps = 4/155 (2%)

Query: 451 SPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRL 510
           S +P     + G+    +  ++    N S EI    K ++G Y C A +  G    + ++
Sbjct: 452 SALPFRLQLRRGEARLGEERHFQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQI 511

Query: 511 EVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDE--PLYIGNRMKKED 568
            V DP        +     G T  L CRV  +    LT  W++D    P   G   +  D
Sbjct: 512 VVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLT--WVRDWRVLPASTGRVAQLAD 569

Query: 569 DSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTV 603
            SL I G+   D G Y CVAS       A  +L V
Sbjct: 570 LSLEISGIIPTDGGRYQCVASNANGVTRASVWLLV 604


>gi|48476182 roundabout, axon guidance receptor, homolog 3 [Homo
           sapiens]
          Length = 1386

 Score =  179 bits (455), Expect = 5e-45
 Identities = 145/493 (29%), Positives = 223/493 (45%), Gaps = 40/493 (8%)

Query: 27  IPMDLTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRN-SRFFNIAKDPRVS 85
           +P  + QPP        D +V   +   + C A+G P P+  W +N +R   + +DPR  
Sbjct: 63  MPRIVEQPP--------DLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAH 114

Query: 86  -MRRRSGTLVID-FRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDP 143
            +   SG L       G R    EG Y C ARN  G A S    L+V+      +++   
Sbjct: 115 RLLLPSGALFFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSPGN 174

Query: 144 VVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQT 203
           VVV  G P  L+C PP G P P + W         ++ R++    G L  S+ +  D   
Sbjct: 175 VVVAVGEPAVLECVPPRGHPEPSVSWRKDGARLKEEEGRITI-RGGKLMMSHTLKSDAGM 233

Query: 204 DYSCNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECI 263
            Y C A    ++   ++     +V+    V ER PSF+       +Q+VL    +   C 
Sbjct: 234 -YVCVA----SNMAGERESAAAEVM----VLER-PSFLR---RPVNQVVLADAPVTFLCE 280

Query: 264 ASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTI 323
             G P P + W K+ G+LP+ + +  + + +L I +VS ED G Y C+A N +G    + 
Sbjct: 281 VKGDPPPRLRWRKEDGELPTGRYEIRS-DHSLWIGHVSAEDEGTYTCVAENSVGRAEASG 339

Query: 324 SVRVKAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGE-----PLQSAPPNP 378
           S+ V   P  + +P++ + APGE     C   GNP P + W   G      P QS  P  
Sbjct: 340 SLSVHVPPQLVTQPQDQMAAPGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTG 399

Query: 379 NREVAG-DTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSV----LD-VPPRMLS-PRN 431
              V+    +     Q      Y C   +  G +LA A + +    LD +PP +L  P N
Sbjct: 400 RFSVSPRGQLNITAVQRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQGPAN 459

Query: 432 QLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQG 491
           Q +  +L +   L C   G+P P++RW K+GQ    D   +    NG+L I  +++ D G
Sbjct: 460 QTL--VLGSSVWLPCRVTGNPQPSVRWKKDGQWLQGDDLQFKTMANGTLYIANVQEMDMG 517

Query: 492 IYTCVATNILGKA 504
            Y+CVA +  G+A
Sbjct: 518 FYSCVAKSSTGEA 530



 Score =  134 bits (337), Expect = 2e-31
 Identities = 116/383 (30%), Positives = 160/383 (41%), Gaps = 41/383 (10%)

Query: 251 MVLRGMDLLLECIASGVPTPDIAWYKKGGD--------------LPSDKAKFENFNKALR 296
           +V RG    L C A G P P+I WYK G                LPS    F       R
Sbjct: 74  LVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHRLLLPSGALFFPRIVHGRR 133

Query: 297 ITNVSEEDSGEYFCLASNKMG---SIRHTISVRVKAAPYWLDEPKNLILAPGEDGRLVC- 352
               +  D G Y C+A N +G   S   ++ V V    +    P N+++A GE   L C 
Sbjct: 134 ----ARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDF-RQSPGNVVVAVGEPAVLECV 188

Query: 353 RANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYL- 411
              G+P+P+V W  +G  L+         + G  ++   T  S   +Y C  SN  G   
Sbjct: 189 PPRGHPEPSVSWRKDGARLKEEEGRIT--IRGGKLMMSHTLKSDAGMYVCVASNMAGERE 246

Query: 412 LANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGN 471
            A A V VL+ P  +  P NQ+  V+        C   G P P LRW K  +   L  G 
Sbjct: 247 SAAAEVMVLERPSFLRRPVNQV--VLADAPVTFLCEVKGDPPPRLRWRK--EDGELPTGR 302

Query: 472 YHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVARRGT 531
           Y +  + SL I  +  ED+G YTCVA N +G+AE    L V  P ++   P+DQ+A  G 
Sbjct: 303 YEIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPPQLVTQPQDQMAAPGE 362

Query: 532 TVQLECRVKHDPSLKLTVSWLKDDEPLYI---------GNRMKKEDDSLTIFGVAERDQG 582
           +V  +C  K +P     + W K+   + +         G         L I  V   D G
Sbjct: 363 SVAFQCETKGNP--PPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNITAVQRGDAG 420

Query: 583 SYTCVASTELDQDLAKAYLTVLG 605
            Y C A +     LAKA L + G
Sbjct: 421 YYVCQAVSVAGSILAKALLEIKG 443



 Score =  128 bits (321), Expect = 2e-29
 Identities = 126/495 (25%), Positives = 207/495 (41%), Gaps = 48/495 (9%)

Query: 144 VVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPIT--QDKRVSQG--HNGDLYFSNVM-- 197
           ++V  G P TL C    G P P I W  +     T  +D R  +    +G L+F  ++  
Sbjct: 73  LLVSRGEPATLPCRAE-GRPRPNIEWYKNGARVATVREDPRAHRLLLPSGALFFPRIVHG 131

Query: 198 --LQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRG 255
              +  +  Y+C AR ++      +N  +L+V   R    ++P          + +V  G
Sbjct: 132 RRARPDEGVYTCVAR-NYLGAAASRNA-SLEVAVLRDDFRQSPG---------NVVVAVG 180

Query: 256 MDLLLECIAS-GVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASN 314
              +LEC+   G P P ++W K G  L  ++ +       L +++  + D+G Y C+ASN
Sbjct: 181 EPAVLECVPPRGHPEPSVSWRKDGARLKEEEGRITIRGGKLMMSHTLKSDAGMYVCVASN 240

Query: 315 KMGSIRHTIS-VRVKAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQS 373
             G      + V V   P +L  P N ++        +C   G+P P ++W      L  
Sbjct: 241 MAGERESAAAEVMVLERPSFLRRPVNQVVLADAPVTFLCEVKGDPPPRLRWRKEDGEL-- 298

Query: 374 APPNPNREVAGD-TIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLS-PRN 431
             P    E+  D ++            Y C   N  G   A+  +SV  VPP++++ P++
Sbjct: 299 --PTGRYEIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSV-HVPPQLVTQPQD 355

Query: 432 QLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNL-------DGGNYHVYENGSLEIKM 484
           Q+            C   G+P P + W K G    L         G + V   G L I  
Sbjct: 356 QMAAP--GESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNITA 413

Query: 485 IRKEDQGIYTCVATNILGKAENQVRLEVKD------PTRIYRMPEDQVARRGTTVQLECR 538
           +++ D G Y C A ++ G    +  LE+K       P  I + P +Q    G++V L CR
Sbjct: 414 VQRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQGPANQTLVLGSSVWLPCR 473

Query: 539 VKHDPSLKLTVSWLKDDEPLYIGNRMKKE--DDSLTIFGVAERDQGSYTCVASTELDQDL 596
           V  +P  + +V W KD + L   +   K   + +L I  V E D G Y+CVA +   +  
Sbjct: 474 VTGNP--QPSVRWKKDGQWLQGDDLQFKTMANGTLYIANVQEMDMGFYSCVAKSSTGEAT 531

Query: 597 AKAYLTVLGNCPCSP 611
              +L +  +   SP
Sbjct: 532 WSGWLKMREDWGVSP 546



 Score =  107 bits (268), Expect = 2e-23
 Identities = 88/288 (30%), Positives = 132/288 (45%), Gaps = 19/288 (6%)

Query: 329 AAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSA--PPNPNREVAGDT 386
           A P  +++P +L+++ GE   L CRA G P+P ++W  NG  + +    P  +R +    
Sbjct: 62  AMPRIVEQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHRLLLPSG 121

Query: 387 IIFRDTQISSR------AVYQCNTSNEHGYLL---ANAFVSVLDVPPRMLSPRNQLIRVI 437
            +F    +  R       VY C   N  G      A+  V+VL    R  SP N ++ V 
Sbjct: 122 ALFFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQ-SPGNVVVAV- 179

Query: 438 LYNRTRLDC-PFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCV 496
                 L+C P  G P P++ W K+G     + G   +   G L +    K D G+Y CV
Sbjct: 180 -GEPAVLECVPPRGHPEPSVSWRKDGARLKEEEGRITI-RGGKLMMSHTLKSDAGMYVCV 237

Query: 497 ATNILGKAEN-QVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDD 555
           A+N+ G+ E+    + V +     R P +QV      V   C VK DP  +L   W K+D
Sbjct: 238 ASNMAGERESAAAEVMVLERPSFLRRPVNQVVLADAPVTFLCEVKGDPPPRL--RWRKED 295

Query: 556 EPLYIGNRMKKEDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTV 603
             L  G    + D SL I  V+  D+G+YTCVA   + +  A   L+V
Sbjct: 296 GELPTGRYEIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSV 343


>gi|19743806 roundabout 1 isoform b [Homo sapiens]
          Length = 1612

 Score =  176 bits (446), Expect = 6e-44
 Identities = 141/497 (28%), Positives = 222/497 (44%), Gaps = 35/497 (7%)

Query: 34  PPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRR--SG 91
           PP I +  + D IV   +   + C+A+G P P+  W +        KD   S R    SG
Sbjct: 28  PPRIVEHPS-DLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSG 86

Query: 92  TLV-IDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGA 150
           +L  +    G +    EG Y C ARN  G A+S+   L+V+      ++N   V+V  G 
Sbjct: 87  SLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGE 146

Query: 151 PLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNAR 210
           P  ++C PP G P P I W         +D+R++    G L  +     D    Y C   
Sbjct: 147 PAVMECQPPRGHPEPTISWKKDGSPLDDKDERITI-RGGKLMITYTRKSD-AGKYVCVG- 203

Query: 211 FHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTP 270
              T+ + ++     ++     V ER PSF+      S+  V        +C A G P P
Sbjct: 204 ---TNMVGERESEVAELT----VLER-PSFV---KRPSNLAVTVDDSAEFKCEARGDPVP 252

Query: 271 DIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAA 330
            + W K  G+LP  + +  + +  L+I  V+  D G Y C+A N +G    + ++ V+  
Sbjct: 253 TVRWRKDDGELPKSRYEIRD-DHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEP 311

Query: 331 PYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEP---LQSAPPNPNREVA---- 383
           P+++ +P++ ++A G      C A GNP+P + W   G         PP  +   +    
Sbjct: 312 PHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQT 371

Query: 384 GDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDV----PPRML--SPRNQLIRVI 437
           GD  I  + Q S    Y C T N  G ++  A++ V DV    PP ++   P NQ + V 
Sbjct: 372 GDLTI-TNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAV- 429

Query: 438 LYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVA 497
                 L C   GSP+PT+ W K+G   +         ENG L+I+  +  D G YTC+A
Sbjct: 430 -DGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIA 488

Query: 498 TNILGKAENQVRLEVKD 514
           +   G+A     +EV++
Sbjct: 489 STPSGEATWSAYIEVQE 505



 Score =  144 bits (362), Expect = 3e-34
 Identities = 110/379 (29%), Positives = 170/379 (44%), Gaps = 31/379 (8%)

Query: 248 SSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKAL--------RITN 299
           S  +V +G    L C A G PTP I WYK G  + +DK    +    L        RI +
Sbjct: 36  SDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVH 95

Query: 300 --VSEEDSGEYFCLASNKMG-SIRHTISVRVKAA-PYWLDEPKNLILAPGEDGRLVCRA- 354
              S  D G Y C+A N +G ++ H  S+ V      +   P ++++A GE   + C+  
Sbjct: 96  GRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPP 155

Query: 355 NGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLAN 414
            G+P+PT+ W  +G PL     +    + G  ++   T+ S    Y C  +N  G   + 
Sbjct: 156 RGHPEPTISWKKDGSPLDDK--DERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERESE 213

Query: 415 -AFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYH 473
            A ++VL+ P  +  P N  + V + +     C   G P+PT+RW K+     L    Y 
Sbjct: 214 VAELTVLERPSFVKRPSN--LAVTVDDSAEFKCEARGDPVPTVRWRKDD--GELPKSRYE 269

Query: 474 VYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTV 533
           + ++ +L+I+ +   D G YTCVA N++GKAE    L V++P      P DQV   G TV
Sbjct: 270 IRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQVVALGRTV 329

Query: 534 QLECRVKHDPSLKLTVSWLKDD--------EPLYIGNRMK-KEDDSLTIFGVAERDQGSY 584
             +C    +P  +  + W ++         +P    +R    +   LTI  V   D G Y
Sbjct: 330 TFQCEATGNP--QPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYY 387

Query: 585 TCVASTELDQDLAKAYLTV 603
            C         + KAYL V
Sbjct: 388 ICQTLNVAGSIITKAYLEV 406



 Score =  142 bits (359), Expect = 7e-34
 Identities = 134/504 (26%), Positives = 206/504 (40%), Gaps = 48/504 (9%)

Query: 127 RLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQG 186
           RL+    P    E+   ++V +G P TL C    G P+P I W     E +  DK   + 
Sbjct: 21  RLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAE-GRPTPTIEWYKGG-ERVETDKDDPRS 78

Query: 187 H-----NGDLYFSNVM----LQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRGVAERT 237
           H     +G L+F  ++     +  +  Y C AR +    +      +L+V   R    + 
Sbjct: 79  HRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNA--SLEVAILRDDFRQN 136

Query: 238 PSFMYPQGTASSQMVLRGMDLLLECIAS-GVPTPDIAWYKKGGDLPSDKAKFENFNKALR 296
           PS +         MV  G   ++EC    G P P I+W K G  L     +       L 
Sbjct: 137 PSDV---------MVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLM 187

Query: 297 ITNVSEEDSGEYFCLASNKMGSIRHTIS-VRVKAAPYWLDEPKNLILAPGEDGRLVCRAN 355
           IT   + D+G+Y C+ +N +G     ++ + V   P ++  P NL +   +     C A 
Sbjct: 188 ITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEAR 247

Query: 356 GNPKPTVQWMVNGEPLQSAPPNPNREVAGD-TIIFRDTQISSRAVYQCNTSNEHGYLLAN 414
           G+P PTV+W  +   L    P    E+  D T+  R         Y C   N  G   A+
Sbjct: 248 GDPVPTVRWRKDDGEL----PKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEAS 303

Query: 415 AFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNL------- 467
           A ++V + P  ++ PR+Q+  V L       C   G+P P + W + G  + L       
Sbjct: 304 ATLTVQEPPHFVVKPRDQV--VALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQ 361

Query: 468 DGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKD------PTRIYRM 521
               + V + G L I  +++ D G Y C   N+ G    +  LEV D      P  I + 
Sbjct: 362 SSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQG 421

Query: 522 PEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYI-GNRMKK-EDDSLTIFGVAER 579
           P +Q      T  L C     P    T+ W KD   +    +R+K+ E+  L I      
Sbjct: 422 PVNQTVAVDGTFVLSCVATGSPVP--TILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLG 479

Query: 580 DQGSYTCVASTELDQDLAKAYLTV 603
           D G YTC+AST   +    AY+ V
Sbjct: 480 DTGRYTCIASTPSGEATWSAYIEV 503



 Score = 38.1 bits (87), Expect = 0.024
 Identities = 29/115 (25%), Positives = 49/115 (42%), Gaps = 7/115 (6%)

Query: 33  QPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGT 92
           +PP + +Q   +  V      ++ C A G+P P+  W ++    +  +D R+  +  +G 
Sbjct: 413 RPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVS-TQDSRIK-QLENGV 470

Query: 93  LVIDFRSGGRPEEYEGEYQCFARNKFGTAL-SNRIRLQVSKSPLWPKENLDPVVV 146
           L I +   G      G Y C A    G A  S  I +Q    P+ P    DP ++
Sbjct: 471 LQIRYAKLGD----TGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLI 521


>gi|4506569 roundabout 1 isoform a [Homo sapiens]
          Length = 1651

 Score =  176 bits (446), Expect = 6e-44
 Identities = 141/497 (28%), Positives = 222/497 (44%), Gaps = 35/497 (7%)

Query: 34  PPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRR--SG 91
           PP I +  + D IV   +   + C+A+G P P+  W +        KD   S R    SG
Sbjct: 67  PPRIVEHPS-DLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSG 125

Query: 92  TLV-IDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGA 150
           +L  +    G +    EG Y C ARN  G A+S+   L+V+      ++N   V+V  G 
Sbjct: 126 SLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGE 185

Query: 151 PLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNAR 210
           P  ++C PP G P P I W         +D+R++    G L  +     D    Y C   
Sbjct: 186 PAVMECQPPRGHPEPTISWKKDGSPLDDKDERITI-RGGKLMITYTRKSD-AGKYVCVG- 242

Query: 211 FHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTP 270
              T+ + ++     ++     V ER PSF+      S+  V        +C A G P P
Sbjct: 243 ---TNMVGERESEVAELT----VLER-PSFV---KRPSNLAVTVDDSAEFKCEARGDPVP 291

Query: 271 DIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAA 330
            + W K  G+LP  + +  + +  L+I  V+  D G Y C+A N +G    + ++ V+  
Sbjct: 292 TVRWRKDDGELPKSRYEIRD-DHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEP 350

Query: 331 PYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEP---LQSAPPNPNREVA---- 383
           P+++ +P++ ++A G      C A GNP+P + W   G         PP  +   +    
Sbjct: 351 PHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQT 410

Query: 384 GDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDV----PPRML--SPRNQLIRVI 437
           GD  I  + Q S    Y C T N  G ++  A++ V DV    PP ++   P NQ + V 
Sbjct: 411 GDLTI-TNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAV- 468

Query: 438 LYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVA 497
                 L C   GSP+PT+ W K+G   +         ENG L+I+  +  D G YTC+A
Sbjct: 469 -DGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIA 527

Query: 498 TNILGKAENQVRLEVKD 514
           +   G+A     +EV++
Sbjct: 528 STPSGEATWSAYIEVQE 544



 Score =  144 bits (362), Expect = 3e-34
 Identities = 110/379 (29%), Positives = 170/379 (44%), Gaps = 31/379 (8%)

Query: 248 SSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKAL--------RITN 299
           S  +V +G    L C A G PTP I WYK G  + +DK    +    L        RI +
Sbjct: 75  SDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVH 134

Query: 300 --VSEEDSGEYFCLASNKMG-SIRHTISVRVKAA-PYWLDEPKNLILAPGEDGRLVCRA- 354
              S  D G Y C+A N +G ++ H  S+ V      +   P ++++A GE   + C+  
Sbjct: 135 GRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPP 194

Query: 355 NGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLAN 414
            G+P+PT+ W  +G PL     +    + G  ++   T+ S    Y C  +N  G   + 
Sbjct: 195 RGHPEPTISWKKDGSPLDDK--DERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERESE 252

Query: 415 -AFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYH 473
            A ++VL+ P  +  P N  + V + +     C   G P+PT+RW K+     L    Y 
Sbjct: 253 VAELTVLERPSFVKRPSN--LAVTVDDSAEFKCEARGDPVPTVRWRKDD--GELPKSRYE 308

Query: 474 VYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTV 533
           + ++ +L+I+ +   D G YTCVA N++GKAE    L V++P      P DQV   G TV
Sbjct: 309 IRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQVVALGRTV 368

Query: 534 QLECRVKHDPSLKLTVSWLKDD--------EPLYIGNRMK-KEDDSLTIFGVAERDQGSY 584
             +C    +P  +  + W ++         +P    +R    +   LTI  V   D G Y
Sbjct: 369 TFQCEATGNP--QPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYY 426

Query: 585 TCVASTELDQDLAKAYLTV 603
            C         + KAYL V
Sbjct: 427 ICQTLNVAGSIITKAYLEV 445



 Score =  142 bits (359), Expect = 7e-34
 Identities = 134/504 (26%), Positives = 206/504 (40%), Gaps = 48/504 (9%)

Query: 127 RLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQG 186
           RL+    P    E+   ++V +G P TL C    G P+P I W     E +  DK   + 
Sbjct: 60  RLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAE-GRPTPTIEWYKGG-ERVETDKDDPRS 117

Query: 187 H-----NGDLYFSNVM----LQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRGVAERT 237
           H     +G L+F  ++     +  +  Y C AR +    +      +L+V   R    + 
Sbjct: 118 HRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNA--SLEVAILRDDFRQN 175

Query: 238 PSFMYPQGTASSQMVLRGMDLLLECIAS-GVPTPDIAWYKKGGDLPSDKAKFENFNKALR 296
           PS +         MV  G   ++EC    G P P I+W K G  L     +       L 
Sbjct: 176 PSDV---------MVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLM 226

Query: 297 ITNVSEEDSGEYFCLASNKMGSIRHTIS-VRVKAAPYWLDEPKNLILAPGEDGRLVCRAN 355
           IT   + D+G+Y C+ +N +G     ++ + V   P ++  P NL +   +     C A 
Sbjct: 227 ITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEAR 286

Query: 356 GNPKPTVQWMVNGEPLQSAPPNPNREVAGD-TIIFRDTQISSRAVYQCNTSNEHGYLLAN 414
           G+P PTV+W  +   L    P    E+  D T+  R         Y C   N  G   A+
Sbjct: 287 GDPVPTVRWRKDDGEL----PKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEAS 342

Query: 415 AFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNL------- 467
           A ++V + P  ++ PR+Q+  V L       C   G+P P + W + G  + L       
Sbjct: 343 ATLTVQEPPHFVVKPRDQV--VALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQ 400

Query: 468 DGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKD------PTRIYRM 521
               + V + G L I  +++ D G Y C   N+ G    +  LEV D      P  I + 
Sbjct: 401 SSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQG 460

Query: 522 PEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYI-GNRMKK-EDDSLTIFGVAER 579
           P +Q      T  L C     P    T+ W KD   +    +R+K+ E+  L I      
Sbjct: 461 PVNQTVAVDGTFVLSCVATGSPVP--TILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLG 518

Query: 580 DQGSYTCVASTELDQDLAKAYLTV 603
           D G YTC+AST   +    AY+ V
Sbjct: 519 DTGRYTCIASTPSGEATWSAYIEV 542



 Score = 38.1 bits (87), Expect = 0.024
 Identities = 29/115 (25%), Positives = 49/115 (42%), Gaps = 7/115 (6%)

Query: 33  QPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGT 92
           +PP + +Q   +  V      ++ C A G+P P+  W ++    +  +D R+  +  +G 
Sbjct: 452 RPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVS-TQDSRIK-QLENGV 509

Query: 93  LVIDFRSGGRPEEYEGEYQCFARNKFGTAL-SNRIRLQVSKSPLWPKENLDPVVV 146
           L I +   G      G Y C A    G A  S  I +Q    P+ P    DP ++
Sbjct: 510 LQIRYAKLGD----TGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLI 560


>gi|224994173 roundabout 1 isoform d [Homo sapiens]
          Length = 1551

 Score =  171 bits (434), Expect = 1e-42
 Identities = 141/500 (28%), Positives = 222/500 (44%), Gaps = 38/500 (7%)

Query: 34  PPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRR--SG 91
           PP I +  + D IV   +   + C+A+G P P+  W +        KD   S R    SG
Sbjct: 28  PPRIVEHPS-DLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSG 86

Query: 92  TLV-IDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGA 150
           +L  +    G +    EG Y C ARN  G A+S+   L+V+      ++N   V+V  G 
Sbjct: 87  SLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGE 146

Query: 151 PLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNAR 210
           P  ++C PP G P P I W         +D+R++    G L  +     D    Y C   
Sbjct: 147 PAVMECQPPRGHPEPTISWKKDGSPLDDKDERITI-RGGKLMITYTRKSD-AGKYVCVG- 203

Query: 211 FHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTP 270
              T+ + ++     ++     V ER PSF+      S+  V        +C A G P P
Sbjct: 204 ---TNMVGERESEVAELT----VLER-PSFV---KRPSNLAVTVDDSAEFKCEARGDPVP 252

Query: 271 DIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAA 330
            + W K  G+LP  + +  + +  L+I  V+  D G Y C+A N +G    + ++ V+  
Sbjct: 253 TVRWRKDDGELPKSRYEIRD-DHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVG 311

Query: 331 ---PYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEP---LQSAPPNPNREVA- 383
              P+++ +P++ ++A G      C A GNP+P + W   G         PP  +   + 
Sbjct: 312 SEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSV 371

Query: 384 ---GDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDV----PPRML--SPRNQLI 434
              GD  I  + Q S    Y C T N  G ++  A++ V DV    PP ++   P NQ +
Sbjct: 372 SQTGDLTI-TNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTV 430

Query: 435 RVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYT 494
            V       L C   GSP+PT+ W K+G   +         ENG L+I+  +  D G YT
Sbjct: 431 AV--DGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYT 488

Query: 495 CVATNILGKAENQVRLEVKD 514
           C+A+   G+A     +EV++
Sbjct: 489 CIASTPSGEATWSAYIEVQE 508



 Score =  137 bits (345), Expect = 3e-32
 Identities = 134/507 (26%), Positives = 206/507 (40%), Gaps = 51/507 (10%)

Query: 127 RLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQG 186
           RL+    P    E+   ++V +G P TL C    G P+P I W     E +  DK   + 
Sbjct: 21  RLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAE-GRPTPTIEWYKGG-ERVETDKDDPRS 78

Query: 187 H-----NGDLYFSNVM----LQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRGVAERT 237
           H     +G L+F  ++     +  +  Y C AR +    +      +L+V   R    + 
Sbjct: 79  HRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNA--SLEVAILRDDFRQN 136

Query: 238 PSFMYPQGTASSQMVLRGMDLLLECIAS-GVPTPDIAWYKKGGDLPSDKAKFENFNKALR 296
           PS +         MV  G   ++EC    G P P I+W K G  L     +       L 
Sbjct: 137 PSDV---------MVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLM 187

Query: 297 ITNVSEEDSGEYFCLASNKMGSIRHTIS-VRVKAAPYWLDEPKNLILAPGEDGRLVCRAN 355
           IT   + D+G+Y C+ +N +G     ++ + V   P ++  P NL +   +     C A 
Sbjct: 188 ITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEAR 247

Query: 356 GNPKPTVQWMVNGEPLQSAPPNPNREVAGD-TIIFRDTQISSRAVYQCNTSNEHGYLLAN 414
           G+P PTV+W  +   L    P    E+  D T+  R         Y C   N  G   A+
Sbjct: 248 GDPVPTVRWRKDDGEL----PKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEAS 303

Query: 415 AFVSVL---DVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNL---- 467
           A ++V    + P  ++ PR+Q+  V L       C   G+P P + W + G  + L    
Sbjct: 304 ATLTVQVGSEPPHFVVKPRDQV--VALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQ 361

Query: 468 ---DGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKD------PTRI 518
                  + V + G L I  +++ D G Y C   N+ G    +  LEV D      P  I
Sbjct: 362 PPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVI 421

Query: 519 YRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYI-GNRMKK-EDDSLTIFGV 576
            + P +Q      T  L C     P    T+ W KD   +    +R+K+ E+  L I   
Sbjct: 422 RQGPVNQTVAVDGTFVLSCVATGSPVP--TILWRKDGVLVSTQDSRIKQLENGVLQIRYA 479

Query: 577 AERDQGSYTCVASTELDQDLAKAYLTV 603
              D G YTC+AST   +    AY+ V
Sbjct: 480 KLGDTGRYTCIASTPSGEATWSAYIEV 506



 Score = 38.1 bits (87), Expect = 0.024
 Identities = 29/115 (25%), Positives = 49/115 (42%), Gaps = 7/115 (6%)

Query: 33  QPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGT 92
           +PP + +Q   +  V      ++ C A G+P P+  W ++    +  +D R+  +  +G 
Sbjct: 416 RPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVS-TQDSRIK-QLENGV 473

Query: 93  LVIDFRSGGRPEEYEGEYQCFARNKFGTAL-SNRIRLQVSKSPLWPKENLDPVVV 146
           L I +   G      G Y C A    G A  S  I +Q    P+ P    DP ++
Sbjct: 474 LQIRYAKLGD----TGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLI 524


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.135    0.421 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,843,238
Number of Sequences: 37866
Number of extensions: 1342176
Number of successful extensions: 10982
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 279
Number of HSP's successfully gapped in prelim test: 164
Number of HSP's that attempted gapping in prelim test: 3199
Number of HSP's gapped (non-prelim): 3533
length of query: 613
length of database: 18,247,518
effective HSP length: 108
effective length of query: 505
effective length of database: 14,157,990
effective search space: 7149784950
effective search space used: 7149784950
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 65 (29.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.