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Search of human proteins with 237858680
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|237858680 neurofascin isoform 5 precursor [Homo sapiens]
(619 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|237858680 neurofascin isoform 5 precursor [Homo sapiens] 1281 0.0
gi|237858682 neurofascin isoform 6 precursor [Homo sapiens] 1262 0.0
gi|237858675 neurofascin isoform 1 precursor [Homo sapiens] 1255 0.0
gi|237858679 neurofascin isoform 3 precursor [Homo sapiens] 1226 0.0
gi|89903008 neurofascin isoform 4 precursor [Homo sapiens] 1226 0.0
gi|237858677 neurofascin isoform 2 precursor [Homo sapiens] 1224 0.0
gi|81158226 neuronal cell adhesion molecule isoform A precursor ... 672 0.0
gi|81158224 neuronal cell adhesion molecule isoform B precursor ... 660 0.0
gi|221316760 L1 cell adhesion molecule isoform 3 precursor [Homo... 455 e-128
gi|13435353 L1 cell adhesion molecule isoform 2 precursor [Homo ... 452 e-127
gi|4557707 L1 cell adhesion molecule isoform 1 precursor [Homo s... 452 e-127
gi|27894376 cell adhesion molecule with homology to L1CAM precur... 406 e-113
gi|7657359 contactin 5 isoform long [Homo sapiens] 244 2e-64
gi|28373129 contactin 5 isoform short [Homo sapiens] 244 2e-64
gi|28373122 contactin 4 isoform a precursor [Homo sapiens] 232 7e-61
gi|4827022 contactin 2 precursor [Homo sapiens] 226 5e-59
gi|75709184 contactin 3 [Homo sapiens] 224 2e-58
gi|28373117 contactin 1 isoform 1 precursor [Homo sapiens] 219 4e-57
gi|28373119 contactin 1 isoform 2 precursor [Homo sapiens] 219 4e-57
gi|7657361 contactin 6 [Homo sapiens] 198 1e-50
gi|61888896 roundabout, axon guidance receptor, homolog 2 isofor... 194 2e-49
gi|193083163 roundabout, axon guidance receptor, homolog 2 isofo... 192 1e-48
gi|48476182 roundabout, axon guidance receptor, homolog 3 [Homo ... 184 3e-46
gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens] 182 6e-46
gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens] 181 1e-45
gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens] 181 1e-45
gi|118572606 hemicentin 1 [Homo sapiens] 180 4e-45
gi|19743806 roundabout 1 isoform b [Homo sapiens] 176 6e-44
gi|4506569 roundabout 1 isoform a [Homo sapiens] 176 6e-44
gi|224994173 roundabout 1 isoform d [Homo sapiens] 171 1e-42
>gi|237858680 neurofascin isoform 5 precursor [Homo sapiens]
Length = 619
Score = 1281 bits (3314), Expect = 0.0
Identities = 619/619 (100%), Positives = 619/619 (100%)
Query: 1 MARQPPPPWVHAAFLLCLLSLGGAIEIPMDPSIQNELTQPPTITKQSAKDHIVDPRDNIL 60
MARQPPPPWVHAAFLLCLLSLGGAIEIPMDPSIQNELTQPPTITKQSAKDHIVDPRDNIL
Sbjct: 1 MARQPPPPWVHAAFLLCLLSLGGAIEIPMDPSIQNELTQPPTITKQSAKDHIVDPRDNIL 60
Query: 61 IECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFA 120
IECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFA
Sbjct: 61 IECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFA 120
Query: 121 RNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSM 180
RNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSM
Sbjct: 121 RNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSM 180
Query: 181 EPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRGVA 240
EPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRGVA
Sbjct: 181 EPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRGVA 240
Query: 241 ERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKA 300
ERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKA
Sbjct: 241 ERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKA 300
Query: 301 LRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRA 360
LRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRA
Sbjct: 301 LRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRA 360
Query: 361 NGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLAN 420
NGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLAN
Sbjct: 361 NGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLAN 420
Query: 421 AFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHV 480
AFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHV
Sbjct: 421 AFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHV 480
Query: 481 YENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTVQ 540
YENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTVQ
Sbjct: 481 YENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTVQ 540
Query: 541 LECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAERDQGSYTCVASTELDQ 600
LECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAERDQGSYTCVASTELDQ
Sbjct: 541 LECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAERDQGSYTCVASTELDQ 600
Query: 601 DLAKAYLTVLGNCPCSPWH 619
DLAKAYLTVLGNCPCSPWH
Sbjct: 601 DLAKAYLTVLGNCPCSPWH 619
>gi|237858682 neurofascin isoform 6 precursor [Homo sapiens]
Length = 613
Score = 1262 bits (3266), Expect = 0.0
Identities = 613/619 (99%), Positives = 613/619 (99%), Gaps = 6/619 (0%)
Query: 1 MARQPPPPWVHAAFLLCLLSLGGAIEIPMDPSIQNELTQPPTITKQSAKDHIVDPRDNIL 60
MARQPPPPWVHAAFLLCLLSLGGAIEIPMD LTQPPTITKQSAKDHIVDPRDNIL
Sbjct: 1 MARQPPPPWVHAAFLLCLLSLGGAIEIPMD------LTQPPTITKQSAKDHIVDPRDNIL 54
Query: 61 IECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFA 120
IECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFA
Sbjct: 55 IECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFA 114
Query: 121 RNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSM 180
RNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSM
Sbjct: 115 RNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSM 174
Query: 181 EPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRGVA 240
EPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRGVA
Sbjct: 175 EPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRGVA 234
Query: 241 ERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKA 300
ERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKA
Sbjct: 235 ERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKA 294
Query: 301 LRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRA 360
LRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRA
Sbjct: 295 LRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRA 354
Query: 361 NGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLAN 420
NGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLAN
Sbjct: 355 NGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLAN 414
Query: 421 AFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHV 480
AFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHV
Sbjct: 415 AFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHV 474
Query: 481 YENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTVQ 540
YENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTVQ
Sbjct: 475 YENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTVQ 534
Query: 541 LECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAERDQGSYTCVASTELDQ 600
LECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAERDQGSYTCVASTELDQ
Sbjct: 535 LECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAERDQGSYTCVASTELDQ 594
Query: 601 DLAKAYLTVLGNCPCSPWH 619
DLAKAYLTVLGNCPCSPWH
Sbjct: 595 DLAKAYLTVLGNCPCSPWH 613
>gi|237858675 neurofascin isoform 1 precursor [Homo sapiens]
Length = 1240
Score = 1255 bits (3248), Expect = 0.0
Identities = 610/612 (99%), Positives = 611/612 (99%)
Query: 1 MARQPPPPWVHAAFLLCLLSLGGAIEIPMDPSIQNELTQPPTITKQSAKDHIVDPRDNIL 60
MARQPPPPWVHAAFLLCLLSLGGAIEIPMDPSIQNELTQPPTITKQSAKDHIVDPRDNIL
Sbjct: 1 MARQPPPPWVHAAFLLCLLSLGGAIEIPMDPSIQNELTQPPTITKQSAKDHIVDPRDNIL 60
Query: 61 IECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFA 120
IECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFA
Sbjct: 61 IECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFA 120
Query: 121 RNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSM 180
RNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSM
Sbjct: 121 RNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSM 180
Query: 181 EPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRGVA 240
EPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRGVA
Sbjct: 181 EPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRGVA 240
Query: 241 ERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKA 300
ERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKA
Sbjct: 241 ERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKA 300
Query: 301 LRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRA 360
LRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRA
Sbjct: 301 LRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRA 360
Query: 361 NGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLAN 420
NGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLAN
Sbjct: 361 NGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLAN 420
Query: 421 AFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHV 480
AFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHV
Sbjct: 421 AFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHV 480
Query: 481 YENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTVQ 540
YENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTVQ
Sbjct: 481 YENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTVQ 540
Query: 541 LECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAERDQGSYTCVASTELDQ 600
LECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAERDQGSYTCVASTELDQ
Sbjct: 541 LECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAERDQGSYTCVASTELDQ 600
Query: 601 DLAKAYLTVLGN 612
DLAKAYLTVL +
Sbjct: 601 DLAKAYLTVLAD 612
>gi|237858679 neurofascin isoform 3 precursor [Homo sapiens]
Length = 1174
Score = 1226 bits (3172), Expect = 0.0
Identities = 604/628 (96%), Positives = 604/628 (96%), Gaps = 23/628 (3%)
Query: 1 MARQPPPPWVHAAFLLCLLSLGGAIEIPMDPSIQNELTQPPTITKQSAKDHIVDPRDNIL 60
MARQPPPPWVHAAFLLCLLSLGGAIEIPMD LTQPPTITKQSAKDHIVDPRDNIL
Sbjct: 1 MARQPPPPWVHAAFLLCLLSLGGAIEIPMD------LTQPPTITKQSAKDHIVDPRDNIL 54
Query: 61 IECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFA 120
IECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFA
Sbjct: 55 IECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFA 114
Query: 121 RNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSM 180
RNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSM
Sbjct: 115 RNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSM 174
Query: 181 EPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTT---- 236
EPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLT
Sbjct: 175 EPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTNHPYN 234
Query: 237 -------------RGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKK 283
RGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKK
Sbjct: 235 DSSLRNHPDMYSARGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKK 294
Query: 284 GGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEP 343
GGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEP
Sbjct: 295 GGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEP 354
Query: 344 KNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSR 403
KNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSR
Sbjct: 355 KNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSR 414
Query: 404 AVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLR 463
AVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLR
Sbjct: 415 AVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLR 474
Query: 464 WFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTR 523
WFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTR
Sbjct: 475 WFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTR 534
Query: 524 IYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVA 583
IYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVA
Sbjct: 535 IYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVA 594
Query: 584 ERDQGSYTCVASTELDQDLAKAYLTVLG 611
ERDQGSYTCVASTELDQDLAKAYLTVLG
Sbjct: 595 ERDQGSYTCVASTELDQDLAKAYLTVLG 622
Score = 98.2 bits (243), Expect = 2e-20
Identities = 96/390 (24%), Positives = 156/390 (40%), Gaps = 53/390 (13%)
Query: 58 NILIECEAKGNPAPSFHWTRN--------SRFFNIAKDPRVSMRRRSGTLVIDFRSGGRP 109
++L+EC A G P P W + ++F N K R++
Sbjct: 274 DLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRIT---------------NVS 318
Query: 110 EEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQ-EGAPLTLQCNPPPGL 168
EE GEY C A NK G+ + + I ++V +P W E + ++ E L + N G
Sbjct: 319 EEDSGEYFCLASNKMGS-IRHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRAN---GN 374
Query: 169 PSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTD----YSCNARFHFTHTIQ 224
P P + WM + EP+ + N ++ ++ +D Q Y CN H
Sbjct: 375 PKPTVQWMVNG-EPL---QSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNE--HGYL 428
Query: 225 QKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKG 284
N F V + P + P+ ++ L +C G P P + W+K G
Sbjct: 429 LANAFV-------SVLDVPPRMLSPRNQLIRVILYNRTRL--DCPFFGSPIPTLRWFKNG 479
Query: 285 GDLPSDKAKFENF-NKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEP 343
D + + N +L I + +ED G Y C+A+N +G + + + VK P
Sbjct: 480 QGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMP 539
Query: 344 KNLILAPGEDGRLVCRANGNP--KPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQIS 401
++ + G +L CR +P K TV W+ + EPL + D++
Sbjct: 540 EDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKED---DSLTIFGVAER 596
Query: 402 SRAVYQCNTSNEHGYLLANAFVSVLDVPPR 431
+ Y C S E LA A+++VL P R
Sbjct: 597 DQGSYTCVASTELDQDLAKAYLTVLGRPDR 626
>gi|89903008 neurofascin isoform 4 precursor [Homo sapiens]
Length = 1169
Score = 1226 bits (3172), Expect = 0.0
Identities = 604/628 (96%), Positives = 604/628 (96%), Gaps = 23/628 (3%)
Query: 1 MARQPPPPWVHAAFLLCLLSLGGAIEIPMDPSIQNELTQPPTITKQSAKDHIVDPRDNIL 60
MARQPPPPWVHAAFLLCLLSLGGAIEIPMD LTQPPTITKQSAKDHIVDPRDNIL
Sbjct: 1 MARQPPPPWVHAAFLLCLLSLGGAIEIPMD------LTQPPTITKQSAKDHIVDPRDNIL 54
Query: 61 IECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFA 120
IECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFA
Sbjct: 55 IECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFA 114
Query: 121 RNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSM 180
RNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSM
Sbjct: 115 RNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSM 174
Query: 181 EPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTT---- 236
EPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLT
Sbjct: 175 EPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTNHPYN 234
Query: 237 -------------RGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKK 283
RGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKK
Sbjct: 235 DSSLRNHPDMYSARGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKK 294
Query: 284 GGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEP 343
GGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEP
Sbjct: 295 GGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEP 354
Query: 344 KNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSR 403
KNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSR
Sbjct: 355 KNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSR 414
Query: 404 AVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLR 463
AVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLR
Sbjct: 415 AVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLR 474
Query: 464 WFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTR 523
WFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTR
Sbjct: 475 WFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTR 534
Query: 524 IYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVA 583
IYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVA
Sbjct: 535 IYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVA 594
Query: 584 ERDQGSYTCVASTELDQDLAKAYLTVLG 611
ERDQGSYTCVASTELDQDLAKAYLTVLG
Sbjct: 595 ERDQGSYTCVASTELDQDLAKAYLTVLG 622
Score = 98.2 bits (243), Expect = 2e-20
Identities = 96/390 (24%), Positives = 156/390 (40%), Gaps = 53/390 (13%)
Query: 58 NILIECEAKGNPAPSFHWTRN--------SRFFNIAKDPRVSMRRRSGTLVIDFRSGGRP 109
++L+EC A G P P W + ++F N K R++
Sbjct: 274 DLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRIT---------------NVS 318
Query: 110 EEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQ-EGAPLTLQCNPPPGL 168
EE GEY C A NK G+ + + I ++V +P W E + ++ E L + N G
Sbjct: 319 EEDSGEYFCLASNKMGS-IRHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRAN---GN 374
Query: 169 PSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTD----YSCNARFHFTHTIQ 224
P P + WM + EP+ + N ++ ++ +D Q Y CN H
Sbjct: 375 PKPTVQWMVNG-EPL---QSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNE--HGYL 428
Query: 225 QKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKG 284
N F V + P + P+ ++ L +C G P P + W+K G
Sbjct: 429 LANAFV-------SVLDVPPRMLSPRNQLIRVILYNRTRL--DCPFFGSPIPTLRWFKNG 479
Query: 285 GDLPSDKAKFENF-NKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEP 343
D + + N +L I + +ED G Y C+A+N +G + + + VK P
Sbjct: 480 QGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMP 539
Query: 344 KNLILAPGEDGRLVCRANGNP--KPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQIS 401
++ + G +L CR +P K TV W+ + EPL + D++
Sbjct: 540 EDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKED---DSLTIFGVAER 596
Query: 402 SRAVYQCNTSNEHGYLLANAFVSVLDVPPR 431
+ Y C S E LA A+++VL P R
Sbjct: 597 DQGSYTCVASTELDQDLAKAYLTVLGRPDR 626
>gi|237858677 neurofascin isoform 2 precursor [Homo sapiens]
Length = 1189
Score = 1224 bits (3167), Expect = 0.0
Identities = 603/629 (95%), Positives = 604/629 (96%), Gaps = 23/629 (3%)
Query: 1 MARQPPPPWVHAAFLLCLLSLGGAIEIPMDPSIQNELTQPPTITKQSAKDHIVDPRDNIL 60
MARQPPPPWVHAAFLLCLLSLGGAIEIPMD LTQPPTITKQSAKDHIVDPRDNIL
Sbjct: 1 MARQPPPPWVHAAFLLCLLSLGGAIEIPMD------LTQPPTITKQSAKDHIVDPRDNIL 54
Query: 61 IECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFA 120
IECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFA
Sbjct: 55 IECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFA 114
Query: 121 RNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSM 180
RNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSM
Sbjct: 115 RNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSM 174
Query: 181 EPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTT---- 236
EPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLT
Sbjct: 175 EPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTNHPYN 234
Query: 237 -------------RGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKK 283
RGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKK
Sbjct: 235 DSSLRNHPDMYSARGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKK 294
Query: 284 GGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEP 343
GGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEP
Sbjct: 295 GGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEP 354
Query: 344 KNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSR 403
KNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSR
Sbjct: 355 KNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSR 414
Query: 404 AVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLR 463
AVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLR
Sbjct: 415 AVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLR 474
Query: 464 WFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTR 523
WFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTR
Sbjct: 475 WFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTR 534
Query: 524 IYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVA 583
IYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVA
Sbjct: 535 IYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVA 594
Query: 584 ERDQGSYTCVASTELDQDLAKAYLTVLGN 612
ERDQGSYTCVASTELDQDLAKAYLTVL +
Sbjct: 595 ERDQGSYTCVASTELDQDLAKAYLTVLAD 623
>gi|81158226 neuronal cell adhesion molecule isoform A precursor
[Homo sapiens]
Length = 1304
Score = 672 bits (1734), Expect = 0.0
Identities = 326/619 (52%), Positives = 429/619 (69%), Gaps = 19/619 (3%)
Query: 15 LLCLLSLGGAIEIPMDPSIQNELTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFH 74
+L L + A+E+P+DP + +L QPPTIT+QS KD+I+DPR+NI+I+CEAKG P PSF
Sbjct: 20 ILFLCQMISALEVPLDPKLLEDLVQPPTITQQSPKDYIIDPRENIVIQCEAKGKPPPSFS 79
Query: 75 WTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRL 134
WTRN F+I KDP V+M+ +GTL+I+ S G+ E YEG YQC ARN+ G A+SN I +
Sbjct: 80 WTRNGTHFDIDKDPLVTMKPGTGTLIINIMSEGKAETYEGVYQCTARNERGAAVSNNIVV 139
Query: 135 QVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHN 194
+ S+SPLW KE L+P+ +Q G L L C PP GLP P+IFWM +S + + Q +RVSQG N
Sbjct: 140 RPSRSPLWTKEKLEPITLQSGQSLVLPCRPPIGLPPPIIFWMDNSFQRLPQSERVSQGLN 199
Query: 195 GDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTT------------------ 236
GDLYFSNV+ +D + DY C ARF+ T TIQQK P ++KV++
Sbjct: 200 GDLYFSNVLPEDTREDYICYARFNHTQTIQQKQPISVKVISVDELNDTIAANLSDTEFYG 259
Query: 237 -RGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFE 295
+ ER P+F+ P+G AS++ LRG L LECIA G+PTP I W K+ G LP ++ ++
Sbjct: 260 AKSSRERPPTFLTPEGNASNKEELRGNVLSLECIAEGLPTPIIYWAKEDGMLPKNRTVYK 319
Query: 296 NFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDGR 355
NF K L+I +VSE DSG Y C+A N +G+I HTISVRVKAAPYW+ P+NL+L+PGEDG
Sbjct: 320 NFEKTLQIIHVSEADSGNYQCIAKNALGAIHHTISVRVKAAPYWITAPQNLVLSPGEDGT 379
Query: 356 LVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHG 415
L+CRANGNPKP + W+ NG P++ AP +P+R++ GDTIIF + Q S AVYQCN SNE+G
Sbjct: 380 LICRANGNPKPRISWLTNGVPIEIAPDDPSRKIDGDTIIFSNVQERSSAVYQCNASNEYG 439
Query: 416 YLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDG 475
YLLANAFV+VL PPR+L+P N L +VI LDC FFGSP+PT+ WFK +GS L
Sbjct: 440 YLLANAFVNVLAEPPRILTPANTLYQVIANRPALLDCAFFGSPLPTIEWFKGAKGSALHE 499
Query: 476 GNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVARR 535
Y ++ENG+LEI + +K+ G YTCVA N LG A+N+V LE+KDPT I + PE V +R
Sbjct: 500 DIYVLHENGTLEIPVAQKDSTGTYTCVARNKLGMAKNEVHLEIKDPTWIVKQPEYAVVQR 559
Query: 536 GTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAERDQGSYTCVAS 595
G+ V EC+VKHD +L LTV WLKD+ L R + D L + V++ D G+YTCVA+
Sbjct: 560 GSMVSFECKVKHDHTLSLTVLWLKDNRELPSDERFTVDKDHLVVADVSDDDSGTYTCVAN 619
Query: 596 TELDQDLAKAYLTVLGNCP 614
T LD A A L+V+ P
Sbjct: 620 TTLDSVSASAVLSVVAPTP 638
>gi|81158224 neuronal cell adhesion molecule isoform B precursor
[Homo sapiens]
Length = 1183
Score = 660 bits (1704), Expect = 0.0
Identities = 324/615 (52%), Positives = 425/615 (69%), Gaps = 25/615 (4%)
Query: 15 LLCLLSLGGAIEIPMDPSIQNELTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFH 74
+L L + A+E+P+D L QPPTIT+QS KD+I+DPR+NI+I+CEAKG P PSF
Sbjct: 20 ILFLCQMISALEVPLD------LVQPPTITQQSPKDYIIDPRENIVIQCEAKGKPPPSFS 73
Query: 75 WTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRL 134
WTRN F+I KDP V+M+ +GTL+I+ S G+ E YEG YQC ARN+ G A+SN I +
Sbjct: 74 WTRNGTHFDIDKDPLVTMKPGTGTLIINIMSEGKAETYEGVYQCTARNERGAAVSNNIVV 133
Query: 135 QVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHN 194
+ S+SPLW KE L+P+ +Q G L L C PP GLP P+IFWM +S + + Q +RVSQG N
Sbjct: 134 RPSRSPLWTKEKLEPITLQSGQSLVLPCRPPIGLPPPIIFWMDNSFQRLPQSERVSQGLN 193
Query: 195 GDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTT------------------ 236
GDLYFSNV+ +D + DY C ARF+ T TIQQK P ++KV++
Sbjct: 194 GDLYFSNVLPEDTREDYICYARFNHTQTIQQKQPISVKVISVDELNDTIAANLSDTEFYG 253
Query: 237 -RGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFE 295
+ ER P+F+ P+G AS++ LRG L LECIA G+PTP I W K+ G LP ++ ++
Sbjct: 254 AKSSRERPPTFLTPEGNASNKEELRGNVLSLECIAEGLPTPIIYWAKEDGMLPKNRTVYK 313
Query: 296 NFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDGR 355
NF K L+I +VSE DSG Y C+A N +G+I HTISVRVKAAPYW+ P+NL+L+PGEDG
Sbjct: 314 NFEKTLQIIHVSEADSGNYQCIAKNALGAIHHTISVRVKAAPYWITAPQNLVLSPGEDGT 373
Query: 356 LVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHG 415
L+CRANGNPKP + W+ NG P++ AP +P+R++ GDTIIF + Q S AVYQCN SNE+G
Sbjct: 374 LICRANGNPKPRISWLTNGVPIEIAPDDPSRKIDGDTIIFSNVQERSSAVYQCNASNEYG 433
Query: 416 YLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDG 475
YLLANAFV+VL PPR+L+P N L +VI LDC FFGSP+PT+ WFK +GS L
Sbjct: 434 YLLANAFVNVLAEPPRILTPANTLYQVIANRPALLDCAFFGSPLPTIEWFKGAKGSALHE 493
Query: 476 GNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVARR 535
Y ++ENG+LEI + +K+ G YTCVA N LG A+N+V LE+KDPT I + PE V +R
Sbjct: 494 DIYVLHENGTLEIPVAQKDSTGTYTCVARNKLGMAKNEVHLEIKDPTWIVKQPEYAVVQR 553
Query: 536 GTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAERDQGSYTCVAS 595
G+ V EC+VKHD +L LTV WLKD+ L R + D L + V++ D G+YTCVA+
Sbjct: 554 GSMVSFECKVKHDHTLSLTVLWLKDNRELPSDERFTVDKDHLVVADVSDDDSGTYTCVAN 613
Query: 596 TELDQDLAKAYLTVL 610
T LD A A L+V+
Sbjct: 614 TTLDSVSASAVLSVV 628
Score = 109 bits (272), Expect = 9e-24
Identities = 106/400 (26%), Positives = 169/400 (42%), Gaps = 37/400 (9%)
Query: 39 QPPT-ITKQSAKDHIVDPRDNIL-IECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRS 96
+PPT +T + + + R N+L +EC A+G P P +W + + R +
Sbjct: 260 RPPTFLTPEGNASNKEELRGNVLSLECIAEGLPTPIIYWAKED---GMLPKNRTVYKNFE 316
Query: 97 GTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLW--PKENLDPVVVQE 154
TL I S E G YQC A+N G A+ + I ++V +P W +NL V+
Sbjct: 317 KTLQIIHVS----EADSGNYQCIAKNALG-AIHHTISVRVKAAPYWITAPQNL---VLSP 368
Query: 155 GAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGD-LYFSNVMLQDMQTDYSC 213
G TL C G P P I W+++ + S+ +GD + FSNV + Y C
Sbjct: 369 GEDGTLICRAN-GNPKPRISWLTNGVPIEIAPDDPSRKIDGDTIIFSNVQERSSAV-YQC 426
Query: 214 NARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGV 273
NA + + + N F V P + P T V+ LL+C G
Sbjct: 427 NASNEYGYLLA--NAFV-------NVLAEPPRILTPANTL--YQVIANRPALLDCAFFGS 475
Query: 274 PTPDIAWYK--KGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISV 331
P P I W+K KG L D N L I ++ +G Y C+A NK+G ++ + +
Sbjct: 476 PLPTIEWFKGAKGSALHEDIYVLHE-NGTLEIPVAQKDSTGTYTCVARNKLGMAKNEVHL 534
Query: 332 RVKAAPYWLDEPKNLILAPGEDGRLVCRANGNP--KPTVQWMVNGEPLQSAPPNPNREVA 389
+K + + +P+ ++ G C+ + TV W+ + L P + V
Sbjct: 535 EIKDPTWIVKQPEYAVVQRGSMVSFECKVKHDHTLSLTVLWLKDNREL---PSDERFTVD 591
Query: 390 GDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVP 429
D ++ D Y C + + A+A +SV+DVP
Sbjct: 592 KDHLVVADVSDDDSGTYTCVANTTLDSVSASAVLSVVDVP 631
Score = 76.3 bits (186), Expect = 8e-14
Identities = 119/525 (22%), Positives = 193/525 (36%), Gaps = 73/525 (13%)
Query: 38 TQPPTITKQSAKDHIVDPRDNILIECEAK-GNPAPSFHWTRNSRFFNIAKDPRVSMRRRS 96
++ P TK+ + + ++++ C G P P W NS F + + RVS + +
Sbjct: 136 SRSPLWTKEKLEPITLQSGQSLVLPCRPPIGLPPPIIFWMDNS-FQRLPQSERVS-QGLN 193
Query: 97 GTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQV-------------------- 136
G L + S PE+ +Y C+AR + + + V
Sbjct: 194 GDL---YFSNVLPEDTREDYICYARFNHTQTIQQKQPISVKVISVDELNDTIAANLSDTE 250
Query: 137 ---SKSP-------LWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQD 186
+KS L P+ N G L+L+C GLP+P+I+W + ++
Sbjct: 251 FYGAKSSRERPPTFLTPEGNASNKEELRGNVLSLECIAE-GLPTPIIYWAKED-GMLPKN 308
Query: 187 KRVSQGHNGDLYFSNVMLQDMQTDYSC---NARFHFTHTIQQKNPFTLKVLTTRGVAERT 243
+ V + L +V D +Y C NA HTI + +
Sbjct: 309 RTVYKNFEKTLQIIHVSEAD-SGNYQCIAKNALGAIHHTISVR-------------VKAA 354
Query: 244 PSFMYPQGTASSQMVLR-GMDLLLECIASGVPTPDIAWYKKGGDL---PSDKAKFENFNK 299
P ++ TA +VL G D L C A+G P P I+W G + P D ++ + +
Sbjct: 355 PYWI----TAPQNLVLSPGEDGTLICRANGNPKPRISWLTNGVPIEIAPDDPSRKIDGDT 410
Query: 300 ALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLI--LAPGEDGRLV 357
+ +NV E S Y C ASN+ G + V V A P + P N + + L
Sbjct: 411 II-FSNVQERSSAVYQCNASNEYGYLLANAFVNVLAEPPRILTPANTLYQVIANRPALLD 469
Query: 358 CRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYL 417
C G+P PT++W G + + T+ Q S Y C N+ G
Sbjct: 470 CAFFGSPLPTIEWF-KGAKGSALHEDIYVLHENGTLEIPVAQKDSTGTYTCVARNKLGMA 528
Query: 418 LANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLR--WFKNGQGSNLDG 475
+ + D P + + + V + +C +L W K+ + L
Sbjct: 529 KNEVHLEIKD--PTWIVKQPEYAVVQRGSMVSFECKVKHDHTLSLTVLWLKDNR--ELPS 584
Query: 476 GNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKD 520
+ L + + +D G YTCVA L L V D
Sbjct: 585 DERFTVDKDHLVVADVSDDDSGTYTCVANTTLDSVSASAVLSVVD 629
Score = 73.6 bits (179), Expect = 5e-13
Identities = 86/343 (25%), Positives = 133/343 (38%), Gaps = 45/343 (13%)
Query: 52 IVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEE 111
++ P ++ + C A GNP P W N IA D R+ G +I E
Sbjct: 365 VLSPGEDGTLICRANGNPKPRISWLTNGVPIEIAPDD--PSRKIDGDTII---FSNVQER 419
Query: 112 YEGEYQCFARNKFGTALSNRIRLQVSKSP--LWPKENLDPVVVQEGAPLTLQCNPPPGLP 169
YQC A N++G L+N +++ P L P L V+ P L C G P
Sbjct: 420 SSAVYQCNASNEYGYLLANAFVNVLAEPPRILTPANTLYQVIANR--PALLDC-AFFGSP 476
Query: 170 SPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPF 229
P I W + + NG L V +D Y+C AR KN
Sbjct: 477 LPTIEWFKGAKGSALHEDIYVLHENGTLEIP-VAQKDSTGTYTCVARNKLG---MAKNEV 532
Query: 230 TLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIA--WYKKGGDL 287
L++ + P+++ Q + +V RG + EC T + W K +L
Sbjct: 533 HLEI--------KDPTWIVKQPEYA--VVQRGSMVSFECKVKHDHTLSLTVLWLKDNREL 582
Query: 288 PSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPY--------- 338
PSD+ +F L + +VS++DSG Y C+A+ + S+ + + V P
Sbjct: 583 PSDE-RFTVDKDHLVVADVSDDDSGTYTCVANTTLDSVSASAVLSVVDVPNPPFDLELTD 641
Query: 339 WLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAP 381
LD+ L PG+D N P ++++ E P
Sbjct: 642 QLDKSVQLSWTPGDD---------NNSPITKFIIEYEDAMHKP 675
>gi|221316760 L1 cell adhesion molecule isoform 3 precursor [Homo
sapiens]
Length = 1248
Score = 455 bits (1171), Expect = e-128
Identities = 229/585 (39%), Positives = 339/585 (57%), Gaps = 5/585 (0%)
Query: 33 IQNELTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSM 92
I EL +PP IT+QS + +V P D+I ++CEA G P F WTR+ F ++ V++
Sbjct: 22 IPEELMEPPVITEQSPRRLVVFPTDDISLKCEASGKPEVQFRWTRDGVHFKPKEELGVTV 81
Query: 93 RR--RSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPV 150
+ SG+ I + + ++G Y+CFA NK GTA+S+ IRL +P WPKE + PV
Sbjct: 82 YQSPHSGSFTITGNNSNFAQRFQGIYRCFASNKLGTAMSHEIRLMAEGAPKWPKETVKPV 141
Query: 151 VVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTD 210
V+EG + L CNPPP I+WM+S + I QD+RV+ G NG+LYF+NV+ D +D
Sbjct: 142 EVEEGESVVLPCNPPPSAEPLRIYWMNSKILHIKQDERVTMGQNGNLYFANVLTSDNHSD 201
Query: 211 YSCNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIA 270
Y C+A F T TI QK P L+V T + +R P ++P ++S + L+G L+LECIA
Sbjct: 202 YICHAHFPGTRTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSSHLVALQGQPLVLECIA 261
Query: 271 SGVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTIS 330
G PTP I W + G +P+D+ ++N NK L++ V EED GEY CLA N +GS RH
Sbjct: 262 EGFPTPTIKWLRPSGPMPADRVTYQNHNKTLQLLKVGEEDDGEYRCLAENSLGSARHAYY 321
Query: 331 VRVKAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAG 390
V V+AAPYWL +P++ + PGE RL C+ G P+P V W +NG P++ + +
Sbjct: 322 VTVEAAPYWLHKPQSHLYGPGETARLDCQVQGRPQPEVTWRINGIPVEELAKDQKYRIQR 381
Query: 391 DTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRL 450
+I + Q S V QC N HG LLANA++ V+ +P ++L+ NQ + + L
Sbjct: 382 GALILSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQLPAKILTADNQTYMAVQGSTAYL 441
Query: 451 DCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKA 510
C FG+P+P+++W + L + Y NG+L I+ ++ D G Y C+A N
Sbjct: 442 LCKAFGAPVPSVQWLDEDGTTVLQDERFFPYANGTLGIRDLQANDTGRYFCLAANDQNNV 501
Query: 511 ENQVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLY-IGNR 569
L+VKD T+I + P + ++G+ V C+ DPSL+ +++W D L +G+
Sbjct: 502 TIMANLKVKDATQITQGPRSTIEKKGSRVTFTCQASFDPSLQPSITWRGDGRDLQELGDS 561
Query: 570 MKK--EDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTVLGN 612
K ED L I + DQG+Y+CVASTELD ++A L V+G+
Sbjct: 562 DKYFIEDGRLVIHSLDYSDQGNYSCVASTELDVVESRAQLLVVGS 606
Score = 67.0 bits (162), Expect = 5e-11
Identities = 72/295 (24%), Positives = 119/295 (40%), Gaps = 28/295 (9%)
Query: 49 KDHIVDPRDNILIECEAKGNPAPSFHWTRNS-RFFNIAKDPRVSMRRRSGTLVIDFRSGG 107
+ H+ P + ++C+ +G P P W N +AKD + ++R G L++ S
Sbjct: 335 QSHLYGPGETARLDCQVQGRPQPEVTWRINGIPVEELAKDQKYRIQR--GALIL---SNV 389
Query: 108 RPEEYEGEYQCFARNKFGTALSNRIRLQVS-KSPLWPKENLDPVVVQEGAPLTLQCNPPP 166
+P + QC ARN+ G L+N V + + +N + VQ G+ L C
Sbjct: 390 QPSDTMVT-QCEARNRHGLLLANAYIYVVQLPAKILTADNQTYMAVQ-GSTAYLLCKAF- 446
Query: 167 GLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQK 226
G P P + W+ + QD+R NG L ++ D R+ Q
Sbjct: 447 GAPVPSVQWLDEDGTTVLQDERFFPYANGTLGIRDLQAND-------TGRYFCLAANDQN 499
Query: 227 NPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPT--PDIAWYKKG 284
N + ++ V + T P+ T +G + C AS P+ P I W G
Sbjct: 500 N---VTIMANLKVKDATQITQGPRSTIEK----KGSRVTFTCQASFDPSLQPSITWRGDG 552
Query: 285 GDLPS--DKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAP 337
DL D K+ + L I ++ D G Y C+AS ++ + + V +P
Sbjct: 553 RDLQELGDSDKYFIEDGRLVIHSLDYSDQGNYSCVASTELDVVESRAQLLVVGSP 607
>gi|13435353 L1 cell adhesion molecule isoform 2 precursor [Homo
sapiens]
Length = 1253
Score = 452 bits (1162), Expect = e-127
Identities = 232/601 (38%), Positives = 346/601 (57%), Gaps = 11/601 (1%)
Query: 17 CLLSLGGAIEIPMDPSIQNELTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWT 76
CLL I+IP + + + +PP IT+QS + +V P D+I ++CEA G P F WT
Sbjct: 17 CLL-----IQIPEEYE-GHHVMEPPVITEQSPRRLVVFPTDDISLKCEASGKPEVQFRWT 70
Query: 77 RNSRFFNIAKDPRVSMRR--RSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRL 134
R+ F ++ V++ + SG+ I + + ++G Y+CFA NK GTA+S+ IRL
Sbjct: 71 RDGVHFKPKEELGVTVYQSPHSGSFTITGNNSNFAQRFQGIYRCFASNKLGTAMSHEIRL 130
Query: 135 QVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHN 194
+P WPKE + PV V+EG + L CNPPP I+WM+S + I QD+RV+ G N
Sbjct: 131 MAEGAPKWPKETVKPVEVEEGESVVLPCNPPPSAEPLRIYWMNSKILHIKQDERVTMGQN 190
Query: 195 GDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTAS 254
G+LYF+NV+ D +DY C+A F T TI QK P L+V T + +R P ++P ++S
Sbjct: 191 GNLYFANVLTSDNHSDYICHAHFPGTRTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSS 250
Query: 255 SQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEY 314
+ L+G L+LECIA G PTP I W + G +P+D+ ++N NK L++ V EED GEY
Sbjct: 251 HLVALQGQPLVLECIAEGFPTPTIKWLRPSGPMPADRVTYQNHNKTLQLLKVGEEDDGEY 310
Query: 315 FCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNG 374
CLA N +GS RH V V+AAPYWL +P++ + PGE RL C+ G P+P V W +NG
Sbjct: 311 RCLAENSLGSARHAYYVTVEAAPYWLHKPQSHLYGPGETARLDCQVQGRPQPEVTWRING 370
Query: 375 EPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLS 434
P++ + + +I + Q S V QC N HG LLANA++ V+ +P ++L+
Sbjct: 371 IPVEELAKDQKYRIQRGALILSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQLPAKILT 430
Query: 435 PRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKE 494
NQ + + L C FG+P+P+++W + L + Y NG+L I+ ++
Sbjct: 431 ADNQTYMAVQGSTAYLLCKAFGAPVPSVQWLDEDGTTVLQDERFFPYANGTLGIRDLQAN 490
Query: 495 DQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLT 554
D G Y C+A N L+VKD T+I + P + ++G+ V C+ DPSL+ +
Sbjct: 491 DTGRYFCLAANDQNNVTIMANLKVKDATQITQGPRSTIEKKGSRVTFTCQASFDPSLQPS 550
Query: 555 VSWLKDDEPLY-IGNRMKK--EDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTVLG 611
++W D L +G+ K ED L I + DQG+Y+CVASTELD ++A L V+G
Sbjct: 551 ITWRGDGRDLQELGDSDKYFIEDGRLVIHSLDYSDQGNYSCVASTELDVVESRAQLLVVG 610
Query: 612 N 612
+
Sbjct: 611 S 611
Score = 67.0 bits (162), Expect = 5e-11
Identities = 72/295 (24%), Positives = 119/295 (40%), Gaps = 28/295 (9%)
Query: 49 KDHIVDPRDNILIECEAKGNPAPSFHWTRNS-RFFNIAKDPRVSMRRRSGTLVIDFRSGG 107
+ H+ P + ++C+ +G P P W N +AKD + ++R G L++ S
Sbjct: 340 QSHLYGPGETARLDCQVQGRPQPEVTWRINGIPVEELAKDQKYRIQR--GALIL---SNV 394
Query: 108 RPEEYEGEYQCFARNKFGTALSNRIRLQVS-KSPLWPKENLDPVVVQEGAPLTLQCNPPP 166
+P + QC ARN+ G L+N V + + +N + VQ G+ L C
Sbjct: 395 QPSDTMVT-QCEARNRHGLLLANAYIYVVQLPAKILTADNQTYMAVQ-GSTAYLLCKAF- 451
Query: 167 GLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQK 226
G P P + W+ + QD+R NG L ++ D R+ Q
Sbjct: 452 GAPVPSVQWLDEDGTTVLQDERFFPYANGTLGIRDLQAND-------TGRYFCLAANDQN 504
Query: 227 NPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPT--PDIAWYKKG 284
N + ++ V + T P+ T +G + C AS P+ P I W G
Sbjct: 505 N---VTIMANLKVKDATQITQGPRSTIEK----KGSRVTFTCQASFDPSLQPSITWRGDG 557
Query: 285 GDLPS--DKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAP 337
DL D K+ + L I ++ D G Y C+AS ++ + + V +P
Sbjct: 558 RDLQELGDSDKYFIEDGRLVIHSLDYSDQGNYSCVASTELDVVESRAQLLVVGSP 612
>gi|4557707 L1 cell adhesion molecule isoform 1 precursor [Homo
sapiens]
Length = 1257
Score = 452 bits (1162), Expect = e-127
Identities = 232/601 (38%), Positives = 346/601 (57%), Gaps = 11/601 (1%)
Query: 17 CLLSLGGAIEIPMDPSIQNELTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWT 76
CLL I+IP + + + +PP IT+QS + +V P D+I ++CEA G P F WT
Sbjct: 17 CLL-----IQIPEEYE-GHHVMEPPVITEQSPRRLVVFPTDDISLKCEASGKPEVQFRWT 70
Query: 77 RNSRFFNIAKDPRVSMRR--RSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRL 134
R+ F ++ V++ + SG+ I + + ++G Y+CFA NK GTA+S+ IRL
Sbjct: 71 RDGVHFKPKEELGVTVYQSPHSGSFTITGNNSNFAQRFQGIYRCFASNKLGTAMSHEIRL 130
Query: 135 QVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHN 194
+P WPKE + PV V+EG + L CNPPP I+WM+S + I QD+RV+ G N
Sbjct: 131 MAEGAPKWPKETVKPVEVEEGESVVLPCNPPPSAEPLRIYWMNSKILHIKQDERVTMGQN 190
Query: 195 GDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTAS 254
G+LYF+NV+ D +DY C+A F T TI QK P L+V T + +R P ++P ++S
Sbjct: 191 GNLYFANVLTSDNHSDYICHAHFPGTRTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSS 250
Query: 255 SQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEY 314
+ L+G L+LECIA G PTP I W + G +P+D+ ++N NK L++ V EED GEY
Sbjct: 251 HLVALQGQPLVLECIAEGFPTPTIKWLRPSGPMPADRVTYQNHNKTLQLLKVGEEDDGEY 310
Query: 315 FCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNG 374
CLA N +GS RH V V+AAPYWL +P++ + PGE RL C+ G P+P V W +NG
Sbjct: 311 RCLAENSLGSARHAYYVTVEAAPYWLHKPQSHLYGPGETARLDCQVQGRPQPEVTWRING 370
Query: 375 EPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLS 434
P++ + + +I + Q S V QC N HG LLANA++ V+ +P ++L+
Sbjct: 371 IPVEELAKDQKYRIQRGALILSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQLPAKILT 430
Query: 435 PRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKE 494
NQ + + L C FG+P+P+++W + L + Y NG+L I+ ++
Sbjct: 431 ADNQTYMAVQGSTAYLLCKAFGAPVPSVQWLDEDGTTVLQDERFFPYANGTLGIRDLQAN 490
Query: 495 DQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLT 554
D G Y C+A N L+VKD T+I + P + ++G+ V C+ DPSL+ +
Sbjct: 491 DTGRYFCLAANDQNNVTIMANLKVKDATQITQGPRSTIEKKGSRVTFTCQASFDPSLQPS 550
Query: 555 VSWLKDDEPLY-IGNRMKK--EDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTVLG 611
++W D L +G+ K ED L I + DQG+Y+CVASTELD ++A L V+G
Sbjct: 551 ITWRGDGRDLQELGDSDKYFIEDGRLVIHSLDYSDQGNYSCVASTELDVVESRAQLLVVG 610
Query: 612 N 612
+
Sbjct: 611 S 611
Score = 67.0 bits (162), Expect = 5e-11
Identities = 72/295 (24%), Positives = 119/295 (40%), Gaps = 28/295 (9%)
Query: 49 KDHIVDPRDNILIECEAKGNPAPSFHWTRNS-RFFNIAKDPRVSMRRRSGTLVIDFRSGG 107
+ H+ P + ++C+ +G P P W N +AKD + ++R G L++ S
Sbjct: 340 QSHLYGPGETARLDCQVQGRPQPEVTWRINGIPVEELAKDQKYRIQR--GALIL---SNV 394
Query: 108 RPEEYEGEYQCFARNKFGTALSNRIRLQVS-KSPLWPKENLDPVVVQEGAPLTLQCNPPP 166
+P + QC ARN+ G L+N V + + +N + VQ G+ L C
Sbjct: 395 QPSDTMVT-QCEARNRHGLLLANAYIYVVQLPAKILTADNQTYMAVQ-GSTAYLLCKAF- 451
Query: 167 GLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQK 226
G P P + W+ + QD+R NG L ++ D R+ Q
Sbjct: 452 GAPVPSVQWLDEDGTTVLQDERFFPYANGTLGIRDLQAND-------TGRYFCLAANDQN 504
Query: 227 NPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPT--PDIAWYKKG 284
N + ++ V + T P+ T +G + C AS P+ P I W G
Sbjct: 505 N---VTIMANLKVKDATQITQGPRSTIEK----KGSRVTFTCQASFDPSLQPSITWRGDG 557
Query: 285 GDLPS--DKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAP 337
DL D K+ + L I ++ D G Y C+AS ++ + + V +P
Sbjct: 558 RDLQELGDSDKYFIEDGRLVIHSLDYSDQGNYSCVASTELDVVESRAQLLVVGSP 612
>gi|27894376 cell adhesion molecule with homology to L1CAM precursor
[Homo sapiens]
Length = 1224
Score = 406 bits (1044), Expect = e-113
Identities = 240/627 (38%), Positives = 331/627 (52%), Gaps = 47/627 (7%)
Query: 15 LLCLLSLGGAIEIPMDPSIQNELTQPPTITKQSAKDHIVDPRDNIL-IECEAKGNPAPSF 73
+ LL AIEIP + + Q PTI KQS K + P D IECEAKGNP P+F
Sbjct: 15 MFLLLKFSKAIEIP------SSVQQVPTIIKQS-KVQVAFPFDEYFQIECEAKGNPEPTF 67
Query: 74 HWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIR 133
WT++ F D R+ SGT I + G ++G+Y+CFA NK G A+S I
Sbjct: 68 SWTKDGNPFYFT-DHRIIPSNNSGTFRIP--NEGHISHFQGKYRCFASNKLGIAMSEEIE 124
Query: 134 LQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGH 193
V P +PKE +DP+ V+EG P+ L CNPP GLP I+WM+ +E I QD+RV
Sbjct: 125 FIVPSVPKFPKEKIDPLEVEEGDPIVLPCNPPKGLPPLHIYWMNIELEHIEQDERVYMSQ 184
Query: 194 NGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTR---------------- 237
GDLYF+NV +D + DY C A F TI QK P L V + +
Sbjct: 185 KGDLYFANVEEKDSRNDYCCFAAFPRLRTIVQKMPMKLTVNSLKHANDSSSSTEIGSKAN 244
Query: 238 GVAERTPSFMYP---QGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKF 294
+ +R P + P G+ SS +L+G LLLEC A G+PTP + W K GGDLP +
Sbjct: 245 SIKQRKPKLLLPPTESGSESSITILKGEILLLECFAEGLPTPQVDWNKIGGDLPKGRETK 304
Query: 295 ENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDG 354
EN+ K L+I NVS +D G Y C ASN +G+ H V V+ P W +P++ + + G +G
Sbjct: 305 ENYGKTLKIENVSYQDKGNYRCTASNFLGTATHDFHVIVEEPPRWTKKPQSAVYSTGSNG 364
Query: 355 RLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTII-----FRDTQISSRAVYQCN 409
L+C A G P+PT++W VNG P+ + P AGD + F + Q + AVYQC
Sbjct: 365 ILLCEAEGEPQPTIKWRVNGSPVDNHP------FAGDVVFPREISFTNLQPNHTAVYQCE 418
Query: 410 TSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQ 469
SN HG +LANA + V+DV P + + + ++ L C FF SP + W K +
Sbjct: 419 ASNVHGTILANANIDVVDVRPLIQTKDGENYATVVGYSAFLHCEFFASPEAVVSWQKVEE 478
Query: 470 GSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPE 529
L+G YH+YENG+L+I +ED G Y+C N +GK L++++ T++ P+
Sbjct: 479 VKPLEGRRYHIYENGTLQINRTTEEDAGSYSCWVENAIGKTAVTANLDIRNATKLRVSPK 538
Query: 530 DQVARRGTTVQLECRVKHDPSLK--LTVSWLKDDEPLYIG----NRMKKEDDSLTIFGVA 583
+ + ++L C K D LK L +SW KD E I R+ + +LTI V
Sbjct: 539 NPRIPKLHMLELHCESKCDSHLKHSLKLSWSKDGEAFEINGTEDGRIIIDGANLTISNVT 598
Query: 584 ERDQGSYTCVASTELDQDLAKAYLTVL 610
DQG Y C A T LD +TVL
Sbjct: 599 LEDQGIYCCSAHTALDSAADITQVTVL 625
Score = 82.4 bits (202), Expect = 1e-15
Identities = 128/580 (22%), Positives = 208/580 (35%), Gaps = 93/580 (16%)
Query: 27 IPMDPSIQNELTQPPTITKQSAKDHIVDPRDNILIECEA-KGNPAPSFHWTRNSRFFNIA 85
I M I+ + P K+ V+ D I++ C KG P +W N +I
Sbjct: 117 IAMSEEIEFIVPSVPKFPKEKIDPLEVEEGDPIVLPCNPPKGLPPLHIYWM-NIELEHIE 175
Query: 86 KDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFAR------------------------ 121
+D RV M ++ + ++ +Y CFA
Sbjct: 176 QDERVYMSQKGDLYFANVEE----KDSRNDYCCFAAFPRLRTIVQKMPMKLTVNSLKHAN 231
Query: 122 -----NKFGTALSNRIRLQVSKSPLWPKEN--LDPVVVQEGAPLTLQCNPPPGLPSPVIF 174
+ G+ +N I+ + K L P E+ + + +G L L+C GLP+P +
Sbjct: 232 DSSSSTEIGSK-ANSIKQRKPKLLLPPTESGSESSITILKGEILLLECFAE-GLPTPQVD 289
Query: 175 WMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNAR------FHFTHTIQQKNP 228
W + + + + + + L NV QD + +Y C A H H I ++ P
Sbjct: 290 WNKIGGD-LPKGRETKENYGKTLKIENVSYQD-KGNYRCTASNFLGTATHDFHVIVEEPP 347
Query: 229 FTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLP 288
K PQ S G + +L C A G P P I W G P
Sbjct: 348 RWTKK---------------PQSAVYST----GSNGILLCEAEGEPQPTIKWRVNGS--P 386
Query: 289 SDKAKFEN---FNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLD--EP 343
D F F + + TN+ + Y C ASN G+I ++ V + +
Sbjct: 387 VDNHPFAGDVVFPREISFTNLQPNHTAVYQCEASNVHGTILANANIDVVDVRPLIQTKDG 446
Query: 344 KNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREV---AGDTIIFRDTQI 400
+N G L C +P+ V W + ++ P R T+ T
Sbjct: 447 ENYATVVGYSAFLHCEFFASPEAVVSW----QKVEEVKPLEGRRYHIYENGTLQINRTTE 502
Query: 401 SSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVI----LYNRTRLDCPFFG 456
Y C N G A + + + +SP+N I + L+ ++ D
Sbjct: 503 EDAGSYSCWVENAIGKTAVTANLDIRNATKLRVSPKNPRIPKLHMLELHCESKCDSHLKH 562
Query: 457 SPIPTLRWFKNGQGSNLDG--GNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQV 514
S L W K+G+ ++G + + +L I + EDQGIY C A L A +
Sbjct: 563 SL--KLSWSKDGEAFEINGTEDGRIIIDGANLTISNVTLEDQGIYCCSAHTALDSAADIT 620
Query: 515 R---LEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSL 551
+ L+V DP + E Q R + E H+ ++
Sbjct: 621 QVTVLDVPDPPENLHLSERQ--NRSVRLTWEAGADHNSNI 658
>gi|7657359 contactin 5 isoform long [Homo sapiens]
Length = 1100
Score = 244 bits (623), Expect = 2e-64
Identities = 173/582 (29%), Positives = 260/582 (44%), Gaps = 38/582 (6%)
Query: 50 DHIVDPRDN----ILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRS 105
D I+ P D+ + + CE +GNP PS+ W RN ++ D R S+ GT +I S
Sbjct: 106 DDIIFPTDSDEKKVALNCEVRGNPVPSYRWLRNGTEIDLESDYRYSLI--DGTFIISNPS 163
Query: 106 GGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPP 165
+ G YQC A N G+ LS LQ + + V V+EG + L C+PP
Sbjct: 164 EAKDS---GHYQCLATNTVGSILSREATLQFAYLGNFSGRTRSAVSVREGQGVVLMCSPP 220
Query: 166 PGLPSPVIFWMSSSMEP-ITQDKR--VSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHT 222
P P + W+ + + +D R +SQ G+LY S V D+ + Y C + T+
Sbjct: 221 PHSPEIIYSWVFNEFPSFVAEDSRRFISQ-ETGNLYISKVQTSDVGS-YICLVKNTVTNA 278
Query: 223 --IQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAW 280
+ P TL+ G E +P ++ +G + +EC A G P P I W
Sbjct: 279 RVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAA----KGTTVKMECFALGNPVPTITW 334
Query: 281 YKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWL 340
K G +PS KA+ L I NV +D+G Y C A N G ++V P+W+
Sbjct: 335 MKVNGYIPS-KARLRKSQAVLEIPNVQLDDAGIYECRAENSRGKNSFRGQLQVYTYPHWV 393
Query: 341 DEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQI 400
++ + L G R C+A G P+PT +W+ NG PL P E+ ++ +
Sbjct: 394 EKLNDTQLDSGSPLRWECKATGKPRPTYRWLKNGVPLS---PQSRVEMVNGVLMIHNVNQ 450
Query: 401 SSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTR---LDCPFFGS 457
S +YQC N++G + A+A + +L P NQL + I+ + + ++C GS
Sbjct: 451 SDAGMYQCLAENKYGAIYASAELKILASAPTFAL--NQLKKTIIVTKDQEVVIECKPQGS 508
Query: 458 PIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLE 517
P PT+ W K G + + + +GSL I K D+G Y C N+ G AE L
Sbjct: 509 PKPTISW-KKGDRAVRENKRIAILPDGSLRILNASKSDEGKYVCRGENVFGSAEIIASLS 567
Query: 518 VKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPL--------YIGNR 569
VK+PTRI P+ G ++ L C+ HD SL +T W +P+ + R
Sbjct: 568 VKEPTRIELTPKRTELTVGESIVLNCKAIHDASLDVTFYWTLKGQPIDFEEEGGHFESIR 627
Query: 570 MKKEDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTVLG 611
+ L I + G Y C T D +A L V G
Sbjct: 628 AQASSADLMIRNILLMHAGRYGCRVQTTADSVSDEAELLVRG 669
Score = 88.6 bits (218), Expect = 2e-17
Identities = 97/374 (25%), Positives = 154/374 (41%), Gaps = 39/374 (10%)
Query: 266 LECIASGVPTPDIAWYKKGG--DLPSDKAKFENFNKALRITNVSE-EDSGEYFCLASNKM 322
L C G P P W + G DL SD ++ + I+N SE +DSG Y CLA+N +
Sbjct: 121 LNCEVRGNPVPSYRWLRNGTEIDLESDY-RYSLIDGTFIISNPSEAKDSGHYQCLATNTV 179
Query: 323 GSI-RHTISVRVKAAPYWLDEPKNLI-LAPGEDGRLVCRANGN-PKPTVQWMVNGEPLQS 379
GSI +++ + ++ + + G+ L+C + P+ W+ N P
Sbjct: 180 GSILSREATLQFAYLGNFSGRTRSAVSVREGQGVVLMCSPPPHSPEIIYSWVFNEFPSFV 239
Query: 380 APPNPNREVAGDT--IIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRN 437
A + R ++ +T + Q S Y C N + NA V PP L+ RN
Sbjct: 240 AEDS-RRFISQETGNLYISKVQTSDVGSYICLVKNT----VTNARVLS---PPTPLTLRN 291
Query: 438 Q----------------LIRVILYNRTRLDCPFFGSPIPTLRWFK-NGQGSNLDGGNYHV 480
+ +++C G+P+PT+ W K NG +
Sbjct: 292 DGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFALGNPVPTITWMKVNGY---IPSKARLR 348
Query: 481 YENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTVQ 540
LEI ++ +D GIY C A N GK + +L+V D G+ ++
Sbjct: 349 KSQAVLEIPNVQLDDAGIYECRAENSRGKNSFRGQLQVYTYPHWVEKLNDTQLDSGSPLR 408
Query: 541 LECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAERDQGSYTCVASTELDQ 600
EC+ P + T WLK+ PL +R++ + L I V + D G Y C+A +
Sbjct: 409 WECKATGKP--RPTYRWLKNGVPLSPQSRVEMVNGVLMIHNVNQSDAGMYQCLAENKYGA 466
Query: 601 DLAKAYLTVLGNCP 614
A A L +L + P
Sbjct: 467 IYASAELKILASAP 480
Score = 66.2 bits (160), Expect = 8e-11
Identities = 65/304 (21%), Positives = 122/304 (40%), Gaps = 38/304 (12%)
Query: 46 QSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRS 105
+ D +D + EC+A G P P++ W +N + P+ + +G L+I
Sbjct: 394 EKLNDTQLDSGSPLRWECKATGKPRPTYRWLKN----GVPLSPQSRVEMVNGVLMIH--- 446
Query: 106 GGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENL-DPVVVQEGAPLTLQCNP 164
+ G YQC A NK+G ++ ++ +P + L ++V + + ++C
Sbjct: 447 -NVNQSDAGMYQCLAENKYGAIYASAELKILASAPTFALNQLKKTIIVTKDQEVVIECK- 504
Query: 165 PPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQ 224
P G P P I W + ++KR++ +G L N D + Y C F
Sbjct: 505 PQGSPKPTISWKKGD-RAVRENKRIAILPDGSLRILNASKSD-EGKYVCRGENVFG---- 558
Query: 225 QKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWY--- 281
+ +++ + V E T + P+ T + G ++L C A + D+ +Y
Sbjct: 559 -----SAEIIASLSVKEPTRIELTPKRTE----LTVGESIVLNCKAIHDASLDVTFYWTL 609
Query: 282 --------KKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRV 333
++GG S +A+ + + L I N+ +G Y C S+ + V
Sbjct: 610 KGQPIDFEEEGGHFESIRAQASSAD--LMIRNILLMHAGRYGCRVQTTADSVSDEAELLV 667
Query: 334 KAAP 337
+ P
Sbjct: 668 RGPP 671
Score = 43.9 bits (102), Expect = 4e-04
Identities = 38/178 (21%), Positives = 76/178 (42%), Gaps = 21/178 (11%)
Query: 37 LTQPPTITKQSAKDHIVDPRDN-ILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRR 95
L PT K I+ +D ++IEC+ +G+P P+ W + R + ++ R+++
Sbjct: 476 LASAPTFALNQLKKTIIVTKDQEVVIECKPQGSPKPTISWKKGDR--AVRENKRIAILPD 533
Query: 96 SGTLVIDFRSGGRPEEYEGEYQCFARNKFGTA--LSNRIRLQVSKSPLWPKENLDPVVVQ 153
+++ + EG+Y C N FG+A +++ + ++ L PK +
Sbjct: 534 GSLRILN-----ASKSDEGKYVCRGENVFGSAEIIASLSVKEPTRIELTPKR----TELT 584
Query: 154 EGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKR-------VSQGHNGDLYFSNVML 204
G + L C V F+ + +PI ++ +Q + DL N++L
Sbjct: 585 VGESIVLNCKAIHDASLDVTFYWTLKGQPIDFEEEGGHFESIRAQASSADLMIRNILL 642
>gi|28373129 contactin 5 isoform short [Homo sapiens]
Length = 1026
Score = 244 bits (623), Expect = 2e-64
Identities = 173/582 (29%), Positives = 260/582 (44%), Gaps = 38/582 (6%)
Query: 50 DHIVDPRDN----ILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRS 105
D I+ P D+ + + CE +GNP PS+ W RN ++ D R S+ GT +I S
Sbjct: 32 DDIIFPTDSDEKKVALNCEVRGNPVPSYRWLRNGTEIDLESDYRYSLI--DGTFIISNPS 89
Query: 106 GGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPP 165
+ G YQC A N G+ LS LQ + + V V+EG + L C+PP
Sbjct: 90 EAKDS---GHYQCLATNTVGSILSREATLQFAYLGNFSGRTRSAVSVREGQGVVLMCSPP 146
Query: 166 PGLPSPVIFWMSSSMEP-ITQDKR--VSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHT 222
P P + W+ + + +D R +SQ G+LY S V D+ + Y C + T+
Sbjct: 147 PHSPEIIYSWVFNEFPSFVAEDSRRFISQ-ETGNLYISKVQTSDVGS-YICLVKNTVTNA 204
Query: 223 --IQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAW 280
+ P TL+ G E +P ++ +G + +EC A G P P I W
Sbjct: 205 RVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAA----KGTTVKMECFALGNPVPTITW 260
Query: 281 YKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWL 340
K G +PS KA+ L I NV +D+G Y C A N G ++V P+W+
Sbjct: 261 MKVNGYIPS-KARLRKSQAVLEIPNVQLDDAGIYECRAENSRGKNSFRGQLQVYTYPHWV 319
Query: 341 DEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQI 400
++ + L G R C+A G P+PT +W+ NG PL P E+ ++ +
Sbjct: 320 EKLNDTQLDSGSPLRWECKATGKPRPTYRWLKNGVPLS---PQSRVEMVNGVLMIHNVNQ 376
Query: 401 SSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTR---LDCPFFGS 457
S +YQC N++G + A+A + +L P NQL + I+ + + ++C GS
Sbjct: 377 SDAGMYQCLAENKYGAIYASAELKILASAPTFAL--NQLKKTIIVTKDQEVVIECKPQGS 434
Query: 458 PIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLE 517
P PT+ W K G + + + +GSL I K D+G Y C N+ G AE L
Sbjct: 435 PKPTISW-KKGDRAVRENKRIAILPDGSLRILNASKSDEGKYVCRGENVFGSAEIIASLS 493
Query: 518 VKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPL--------YIGNR 569
VK+PTRI P+ G ++ L C+ HD SL +T W +P+ + R
Sbjct: 494 VKEPTRIELTPKRTELTVGESIVLNCKAIHDASLDVTFYWTLKGQPIDFEEEGGHFESIR 553
Query: 570 MKKEDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTVLG 611
+ L I + G Y C T D +A L V G
Sbjct: 554 AQASSADLMIRNILLMHAGRYGCRVQTTADSVSDEAELLVRG 595
Score = 88.6 bits (218), Expect = 2e-17
Identities = 97/374 (25%), Positives = 154/374 (41%), Gaps = 39/374 (10%)
Query: 266 LECIASGVPTPDIAWYKKGG--DLPSDKAKFENFNKALRITNVSE-EDSGEYFCLASNKM 322
L C G P P W + G DL SD ++ + I+N SE +DSG Y CLA+N +
Sbjct: 47 LNCEVRGNPVPSYRWLRNGTEIDLESDY-RYSLIDGTFIISNPSEAKDSGHYQCLATNTV 105
Query: 323 GSI-RHTISVRVKAAPYWLDEPKNLI-LAPGEDGRLVCRANGN-PKPTVQWMVNGEPLQS 379
GSI +++ + ++ + + G+ L+C + P+ W+ N P
Sbjct: 106 GSILSREATLQFAYLGNFSGRTRSAVSVREGQGVVLMCSPPPHSPEIIYSWVFNEFPSFV 165
Query: 380 APPNPNREVAGDT--IIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRN 437
A + R ++ +T + Q S Y C N + NA V PP L+ RN
Sbjct: 166 AEDS-RRFISQETGNLYISKVQTSDVGSYICLVKNT----VTNARVLS---PPTPLTLRN 217
Query: 438 Q----------------LIRVILYNRTRLDCPFFGSPIPTLRWFK-NGQGSNLDGGNYHV 480
+ +++C G+P+PT+ W K NG +
Sbjct: 218 DGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFALGNPVPTITWMKVNGY---IPSKARLR 274
Query: 481 YENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTVQ 540
LEI ++ +D GIY C A N GK + +L+V D G+ ++
Sbjct: 275 KSQAVLEIPNVQLDDAGIYECRAENSRGKNSFRGQLQVYTYPHWVEKLNDTQLDSGSPLR 334
Query: 541 LECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAERDQGSYTCVASTELDQ 600
EC+ P + T WLK+ PL +R++ + L I V + D G Y C+A +
Sbjct: 335 WECKATGKP--RPTYRWLKNGVPLSPQSRVEMVNGVLMIHNVNQSDAGMYQCLAENKYGA 392
Query: 601 DLAKAYLTVLGNCP 614
A A L +L + P
Sbjct: 393 IYASAELKILASAP 406
Score = 66.2 bits (160), Expect = 8e-11
Identities = 65/304 (21%), Positives = 122/304 (40%), Gaps = 38/304 (12%)
Query: 46 QSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRS 105
+ D +D + EC+A G P P++ W +N + P+ + +G L+I
Sbjct: 320 EKLNDTQLDSGSPLRWECKATGKPRPTYRWLKN----GVPLSPQSRVEMVNGVLMIH--- 372
Query: 106 GGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENL-DPVVVQEGAPLTLQCNP 164
+ G YQC A NK+G ++ ++ +P + L ++V + + ++C
Sbjct: 373 -NVNQSDAGMYQCLAENKYGAIYASAELKILASAPTFALNQLKKTIIVTKDQEVVIECK- 430
Query: 165 PPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQ 224
P G P P I W + ++KR++ +G L N D + Y C F
Sbjct: 431 PQGSPKPTISWKKGD-RAVRENKRIAILPDGSLRILNASKSD-EGKYVCRGENVFG---- 484
Query: 225 QKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWY--- 281
+ +++ + V E T + P+ T + G ++L C A + D+ +Y
Sbjct: 485 -----SAEIIASLSVKEPTRIELTPKRTE----LTVGESIVLNCKAIHDASLDVTFYWTL 535
Query: 282 --------KKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRV 333
++GG S +A+ + + L I N+ +G Y C S+ + V
Sbjct: 536 KGQPIDFEEEGGHFESIRAQASSAD--LMIRNILLMHAGRYGCRVQTTADSVSDEAELLV 593
Query: 334 KAAP 337
+ P
Sbjct: 594 RGPP 597
Score = 43.9 bits (102), Expect = 4e-04
Identities = 38/178 (21%), Positives = 76/178 (42%), Gaps = 21/178 (11%)
Query: 37 LTQPPTITKQSAKDHIVDPRDN-ILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRR 95
L PT K I+ +D ++IEC+ +G+P P+ W + R + ++ R+++
Sbjct: 402 LASAPTFALNQLKKTIIVTKDQEVVIECKPQGSPKPTISWKKGDR--AVRENKRIAILPD 459
Query: 96 SGTLVIDFRSGGRPEEYEGEYQCFARNKFGTA--LSNRIRLQVSKSPLWPKENLDPVVVQ 153
+++ + EG+Y C N FG+A +++ + ++ L PK +
Sbjct: 460 GSLRILN-----ASKSDEGKYVCRGENVFGSAEIIASLSVKEPTRIELTPKR----TELT 510
Query: 154 EGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKR-------VSQGHNGDLYFSNVML 204
G + L C V F+ + +PI ++ +Q + DL N++L
Sbjct: 511 VGESIVLNCKAIHDASLDVTFYWTLKGQPIDFEEEGGHFESIRAQASSADLMIRNILL 568
>gi|28373122 contactin 4 isoform a precursor [Homo sapiens]
Length = 1026
Score = 232 bits (592), Expect = 7e-61
Identities = 167/566 (29%), Positives = 253/566 (44%), Gaps = 29/566 (5%)
Query: 59 ILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQC 118
+ + CE KGNP P W N + D R S+ G+L+I+ + G YQC
Sbjct: 46 VKLNCEVKGNPKPHIRWKLNGTDVDTGMDFRYSVVE--GSLLIN---NPNKTQDAGTYQC 100
Query: 119 FARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSS 178
A N FGT +S +LQ + + V V+ G + L C PPP W+ +
Sbjct: 101 TATNSFGTIVSREAKLQFAYLDNFKTRTRSTVSVRRGQGMVLLCGPPPHSGELSYAWIFN 160
Query: 179 SMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTH--TIQQKNPFTLKVLTT 236
++R G+LY + V D+ +Y+C T+ + P L+
Sbjct: 161 EYPSYQDNRRFVSQETGNLYIAKVEKSDVG-NYTCVVTNTVTNHKVLGPPTPLILRNDGV 219
Query: 237 RGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFEN 296
G E +P+ ++ +G + LEC A G P P I W + G + KA+
Sbjct: 220 MGEYEPKIEVQFPETVPTA----KGATVKLECFALGNPVPTIIWRRADGKPIARKARRHK 275
Query: 297 FNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDGRL 356
N L I N +ED+G Y C+A N G + A P W+ + ++ +A E+
Sbjct: 276 SNGILEIPNFQQEDAGLYECVAENSRGKNVARGQLTFYAQPNWIQKINDIHVAMEENVFW 335
Query: 357 VCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGY 416
C+ANG PKPT +W+ NGEPL + ++ T+ +S +YQC N+HG
Sbjct: 336 ECKANGRPKPTYKWLKNGEPLLT---RDRIQIEQGTLNITIVNLSDAGMYQCLAENKHGV 392
Query: 417 LLANAFVSVLDVPP---RMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNL 473
+ +NA +SV+ V P R L R L++V ++C SP P W K G+
Sbjct: 393 IFSNAELSVIAVGPDFSRTLLKRVTLVKV--GGEVVIECKPKASPKPVYTW-KKGRDILK 449
Query: 474 DGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVA 533
+ + E+G+L I + K D G YTC+ATN G A + L VKDPTR+ P
Sbjct: 450 ENERITISEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKDPTRVMVPPSSMDV 509
Query: 534 RRGTTVQLECRVKHDPSLKLTVSW------LKDDEPLYIGNRMKKEDDS--LTIFGVAER 585
G ++ L C+V HD SL + +W + D R+ +D + L I + +
Sbjct: 510 TVGESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQDSAGDLMIRNIQLK 569
Query: 586 DQGSYTCVASTELDQDLAKAYLTVLG 611
G Y C+ T +D+ A A L V G
Sbjct: 570 HAGKYVCMVQTSVDRLSAAADLIVRG 595
Score = 88.6 bits (218), Expect = 2e-17
Identities = 101/373 (27%), Positives = 156/373 (41%), Gaps = 38/373 (10%)
Query: 266 LECIASGVPTPDIAWYKKGGDLPSDKA-KFENFNKALRITNVSE-EDSGEYFCLASNKMG 323
L C G P P I W G D+ + ++ +L I N ++ +D+G Y C A+N G
Sbjct: 48 LNCEVKGNPKPHIRWKLNGTDVDTGMDFRYSVVEGSLLINNPNKTQDAGTYQCTATNSFG 107
Query: 324 SIRHTISVRVKAAPYWLDEPKN-----LILAPGEDGRLVCRANGNPKP-----TVQWMVN 373
+I +S K +LD K + + G+ L+C P P + W+ N
Sbjct: 108 TI---VSREAKLQFAYLDNFKTRTRSTVSVRRGQGMVLLC----GPPPHSGELSYAWIFN 160
Query: 374 GEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQC---NTSNEHGYL-------LANAFV 423
P + G+ I + + S Y C NT H L L N V
Sbjct: 161 EYPSYQDNRRFVSQETGNLYIAK-VEKSDVGNYTCVVTNTVTNHKVLGPPTPLILRNDGV 219
Query: 424 SVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYEN 483
+ + P++ + + +L+C G+P+PT+ W + G + N
Sbjct: 220 -MGEYEPKIEVQFPETVPTAKGATVKLECFALGNPVPTIIW-RRADGKPIARKARRHKSN 277
Query: 484 GSLEIKMIRKEDQGIYTCVATNILGK--AENQVRLEVKDPTRIYRMPEDQVARRGTTVQL 541
G LEI ++ED G+Y CVA N GK A Q+ + P I ++ + VA V
Sbjct: 278 GILEIPNFQQEDAGLYECVAENSRGKNVARGQLTFYAQ-PNWIQKINDIHVAME-ENVFW 335
Query: 542 ECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAERDQGSYTCVASTELDQD 601
EC+ P K T WLK+ EPL +R++ E +L I V D G Y C+A +
Sbjct: 336 ECKANGRP--KPTYKWLKNGEPLLTRDRIQIEQGTLNITIVNLSDAGMYQCLAENKHGVI 393
Query: 602 LAKAYLTVLGNCP 614
+ A L+V+ P
Sbjct: 394 FSNAELSVIAVGP 406
Score = 70.9 bits (172), Expect = 3e-12
Identities = 73/307 (23%), Positives = 120/307 (39%), Gaps = 44/307 (14%)
Query: 46 QSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRS 105
Q D V +N+ EC+A G P P++ W +N + R+ + + + + I S
Sbjct: 320 QKINDIHVAMEENVFWECKANGRPKPTYKWLKNGE--PLLTRDRIQIEQGTLNITIVNLS 377
Query: 106 GGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPV-VVQEGAPLTLQCNP 164
G YQC A NK G SN ++ P + + L V +V+ G + ++C P
Sbjct: 378 DA------GMYQCLAENKHGVIFSNAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKP 431
Query: 165 PPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQ 224
P PV W + + +++R++ +G+L NV D + Y+C A HF
Sbjct: 432 KAS-PKPVYTW-KKGRDILKENERITISEDGNLRIINVTKSDAGS-YTCIATNHF----- 483
Query: 225 QKNPFTLKVLTTRGVAERTPSFMYPQGT-----ASSQMVLRGMDLLLECIASGVPTPDI- 278
G A T + + T SS V G ++L C + + DI
Sbjct: 484 -------------GTASSTGNLVVKDPTRVMVPPSSMDVTVGESIVLPCQVTHDHSLDIV 530
Query: 279 -AWYKKGG--DLPSDKAKFENFNKA-----LRITNVSEEDSGEYFCLASNKMGSIRHTIS 330
W G D D FE L I N+ + +G+Y C+ + +
Sbjct: 531 FTWSFNGHLIDFDRDGDHFERVGGQDSAGDLMIRNIQLKHAGKYVCMVQTSVDRLSAAAD 590
Query: 331 VRVKAAP 337
+ V+ P
Sbjct: 591 LIVRGPP 597
Score = 58.5 bits (140), Expect = 2e-08
Identities = 48/157 (30%), Positives = 75/157 (47%), Gaps = 12/157 (7%)
Query: 447 RTRLDCPFFGSPIPTLRWFKNGQGSNLDGG---NYHVYENGSLEIKMIRKEDQGIYTCVA 503
+ +L+C G+P P +RW N G+++D G Y V E L + +D G Y C A
Sbjct: 45 KVKLNCEVKGNPKPHIRWKLN--GTDVDTGMDFRYSVVEGSLLINNPNKTQDAGTYQCTA 102
Query: 504 TNILG---KAENQVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKD 560
TN G E +++ D + R RRG + L C S +L+ +W+ +
Sbjct: 103 TNSFGTIVSREAKLQFAYLDNFKT-RTRSTVSVRRGQGMVLLCG-PPPHSGELSYAWIFN 160
Query: 561 DEPLYIGNR--MKKEDDSLTIFGVAERDQGSYTCVAS 595
+ P Y NR + +E +L I V + D G+YTCV +
Sbjct: 161 EYPSYQDNRRFVSQETGNLYIAKVEKSDVGNYTCVVT 197
>gi|4827022 contactin 2 precursor [Homo sapiens]
Length = 1040
Score = 226 bits (576), Expect = 5e-59
Identities = 174/571 (30%), Positives = 251/571 (43%), Gaps = 35/571 (6%)
Query: 57 DNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEY 116
+ +L+ C A+ +P ++ W N + +P + G LVI + G Y
Sbjct: 55 EQVLLACRARASPPATYRWKMNGTEMKL--EPGSRHQLVGGNLVI---MNPTKAQDAGVY 109
Query: 117 QCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWM 176
QC A N GT +S L+ + KE DPV EG + L CNPP P W+
Sbjct: 110 QCLASNPVGTVVSREAILRFGFLQEFSKEERDPVKAHEGWGVMLPCNPPAHYPGLSYRWL 169
Query: 177 SSSMEPI--TQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQK-NPFTLKV 233
+ T + G+LY + D+ +YSC A H + + + F
Sbjct: 170 LNEFPNFIPTDGRHFVSQTTGNLYIARTNASDLG-NYSCLATSHMDFSTKSVFSKFAQLN 228
Query: 234 LTTRGVAERTPSFM--YPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDK 291
L PS +P T + L G + LEC A G P P I W K G L
Sbjct: 229 LAAEDTRLFAPSIKARFPAETYA----LVGQQVTLECFAFGNPVPRIKWRKVDGSL---S 281
Query: 292 AKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVR--VKAAPYWLDEPKNLILA 349
++ L+I +VS ED G Y C A N G R T+ R V+A P WL +
Sbjct: 282 PQWTTAEPTLQIPSVSFEDEGTYECEAENSKG--RDTVQGRIIVQAQPEWLKVISDTEAD 339
Query: 350 PGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCN 409
G + R C A G P+PTV+W+ NGEPL S N +AGD + F + +YQC
Sbjct: 340 IGSNLRWGCAAAGKPRPTVRWLRNGEPLASQ--NRVEVLAGD-LRFSKLSLEDSGMYQCV 396
Query: 410 TSNEHGYLLANAFVSVLDVPPRM-LSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNG 468
N+HG + A+A ++V + P L+P +LI + C +P + W K G
Sbjct: 397 AENKHGTIYASAELAVQALAPDFRLNPVRRLIPAARGGEILIPCQPRAAPKAVVLWSK-G 455
Query: 469 QGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMP 528
++ V +G+L I+ I + D+G YTC A N +GKA + L V+D T+I P
Sbjct: 456 TEILVNSSRVTVTPDGTLIIRNISRSDEGKYTCFAENFMGKANSTGILSVRDATKITLAP 515
Query: 529 EDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPL--------YIGNRMKKEDDSLTIF 580
G + L+C HDP++ LT +W DD P+ Y +K+ LTI
Sbjct: 516 SSADINLGDNLTLQCHASHDPTMDLTFTWTLDDFPIDFDKPGGHYRRTNVKETIGDLTIL 575
Query: 581 GVAERDQGSYTCVASTELDQDLAKAYLTVLG 611
R G YTC+A T +D +A + V G
Sbjct: 576 NAQLRHGGKYTCMAQTVVDSASKEATVLVRG 606
Score = 83.2 bits (204), Expect = 7e-16
Identities = 92/392 (23%), Positives = 160/392 (40%), Gaps = 41/392 (10%)
Query: 245 SFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDL---PSDKAKFENFNKAL 301
S ++P+ + Q+ LL C A P W G ++ P + + N +
Sbjct: 45 SVLFPEESTEEQV-------LLACRARASPPATYRWKMNGTEMKLEPGSRHQLVGGNLVI 97
Query: 302 RITNVSEEDSGEYFCLASNKMGSI--RHTISVRVKAAPYWLDEPKNLILA-PGEDGRLVC 358
+ +D+G Y CLASN +G++ R I +R + E ++ + A G L C
Sbjct: 98 -MNPTKAQDAGVYQCLASNPVGTVVSREAI-LRFGFLQEFSKEERDPVKAHEGWGVMLPC 155
Query: 359 RANGN-PKPTVQWMVNGEPLQSAPPNPNREVAGDT---IIFRDTQISSRAVYQCNTSNEH 414
+ P + +W++N P + P R T + T S Y C ++
Sbjct: 156 NPPAHYPGLSYRWLLNEFP--NFIPTDGRHFVSQTTGNLYIARTNASDLGNYSCLATSHM 213
Query: 415 GYLLANAF-----VSVLDVPPRMLSPRNQL-----IRVILYNRTRLDCPFFGSPIPTLRW 464
+ + F +++ R+ +P + ++ + L+C FG+P+P ++W
Sbjct: 214 DFSTKSVFSKFAQLNLAAEDTRLFAPSIKARFPAETYALVGQQVTLECFAFGNPVPRIKW 273
Query: 465 FKNGQGSNLDGGNYHVYENG--SLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPT 522
K +DG + +L+I + ED+G Y C A N G+ Q R+ V+
Sbjct: 274 RK------VDGSLSPQWTTAEPTLQIPSVSFEDEGTYECEAENSKGRDTVQGRIIVQAQP 327
Query: 523 RIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGV 582
++ D A G+ ++ C P + TV WL++ EPL NR++ L +
Sbjct: 328 EWLKVISDTEADIGSNLRWGCAAAGKP--RPTVRWLRNGEPLASQNRVEVLAGDLRFSKL 385
Query: 583 AERDQGSYTCVASTELDQDLAKAYLTVLGNCP 614
+ D G Y CVA + A A L V P
Sbjct: 386 SLEDSGMYQCVAENKHGTIYASAELAVQALAP 417
Score = 72.4 bits (176), Expect = 1e-12
Identities = 88/337 (26%), Positives = 125/337 (37%), Gaps = 59/337 (17%)
Query: 50 DHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRP 109
D D N+ C A G P P+ W RN +P S + R L D R
Sbjct: 335 DTEADIGSNLRWGCAAAGKPRPTVRWLRNG-------EPLAS-QNRVEVLAGDLRFSKLS 386
Query: 110 EEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPV----VVQEGAPLTLQCNPP 165
E G YQC A NK GT ++ +++ L P L+PV G + + C P
Sbjct: 387 LEDSGMYQCVAENKHGTIYAS---AELAVQALAPDFRLNPVRRLIPAARGGEILIPCQ-P 442
Query: 166 PGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQ 225
P V+ W S E + RV+ +G L N+ D + Y+C F
Sbjct: 443 RAAPKAVVLW-SKGTEILVNSSRVTVTPDGTLIIRNISRSD-EGKYTC-----FAENFMG 495
Query: 226 KNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGG 285
K T +L+ R + T + SS + G +L L+C AS PT D+ +
Sbjct: 496 KANST-GILSVRDATKITLA-------PSSADINLGDNLTLQCHASHDPTMDLTFTWTLD 547
Query: 286 DLPSDKAKFENFNKALRITNVSE------------EDSGEYFCLASNKMGSIRHTISVRV 333
D P D F+ R TNV E G+Y C+A + S +V V
Sbjct: 548 DFPID---FDKPGGHYRRTNVKETIGDLTILNAQLRHGGKYTCMAQTVVDSASKEATVLV 604
Query: 334 KAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQW 370
+ PG G +V R G+ + W
Sbjct: 605 RG-------------PPGPPGGVVVRDIGDTTIQLSW 628
>gi|75709184 contactin 3 [Homo sapiens]
Length = 1028
Score = 224 bits (571), Expect = 2e-58
Identities = 172/624 (27%), Positives = 267/624 (42%), Gaps = 49/624 (7%)
Query: 8 PWVHAAFLLCLLSLGGAIEIPMDPSIQNELTQPPTITKQSAKDHI-VDPRDN-ILIECEA 65
PW L + LGG + L Q P K+ + V D I + CEA
Sbjct: 4 PWKQLILLSFIGCLGGEL-----------LLQGPVFIKEPSNSIFPVGSEDKKITLHCEA 52
Query: 66 KGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFG 125
+GNP+P + W N +++ + R + G LV+ G YQCFA N G
Sbjct: 53 RGNPSPHYRWQLNGSDIDMSMEHRYKLN--GGNLVV---INPNRNWDTGTYQCFATNSLG 107
Query: 126 TALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQ 185
T +S +LQ + + + V V+EG + L C PPP W+ + +
Sbjct: 108 TIVSREAKLQFAYLENFKTKMRSTVSVREGQGVVLLCGPPPHSGELSYAWIFNEYPSFVE 167
Query: 186 D--KRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHT--IQQKNPFTLKVLTTRGVAE 241
+ +R G LY S V D+ +Y+C T+ + P L+ G E
Sbjct: 168 EDSRRFVSQETGHLYISKVEPSDVG-NYTCVVTSMVTNARVLGSPTPLVLRSDGVMGEYE 226
Query: 242 RTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKAL 301
+P+ ++ +G + LEC A G P P I W + G S K K F+ L
Sbjct: 227 PKIEVQFPETLPAA----KGSTVKLECFALGNPIPQINWRRSDGLPFSSKIKLRKFSGVL 282
Query: 302 RITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRAN 361
I N +ED+G Y C+A N G + A P+W+ K++ +A + CRA+
Sbjct: 283 EIPNFQQEDAGSYECIAENSRGKNVARGRLTYYAKPHWVQLIKDVEIAVEDSLYWECRAS 342
Query: 362 GNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANA 421
G PKP+ +W+ NG L ++ + + ++ ++QC N+HG + ++A
Sbjct: 343 GKPKPSYRWLKNGAALVL---EERTQIENGALTISNLSVTDSGMFQCIAENKHGLVYSSA 399
Query: 422 FVSVL-DVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHV 480
+ V+ P +P +L++V + + LDC SP W K G S + +
Sbjct: 400 ELKVVASAPDFSKNPMKKLVQVQVGSLVSLDCKPRASPRALSSW-KKGDVSVQEHERISL 458
Query: 481 YENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTVQ 540
+G L+I + K D G YTC+A N GKA L V +PTRI P + G +V
Sbjct: 459 LNDGGLKIANVTKADAGTYTCMAENQFGKANGTTHLVVTEPTRITLAPSNMDVSVGESVI 518
Query: 541 LECRVKHDPSLKLTVSW--------LKDDEPLYIGNRMKKEDDS----LTIFGVAERDQG 588
L C+V+HDP L + +W K D G+ +K S L I + + G
Sbjct: 519 LPCQVQHDPLLDIIFTWYFNGALADFKKD-----GSHFEKVGGSSSGDLMIRNIQLKHSG 573
Query: 589 SYTCVASTELDQDLAKAYLTVLGN 612
Y C+ T +D + A L V G+
Sbjct: 574 KYVCMVQTGVDSVSSAADLIVRGS 597
Score = 81.6 bits (200), Expect = 2e-15
Identities = 81/301 (26%), Positives = 128/301 (42%), Gaps = 33/301 (10%)
Query: 46 QSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRS 105
Q KD + D++ EC A G P PS+ W +N + + ++ +G L I S
Sbjct: 322 QLIKDVEIAVEDSLYWECRASGKPKPSYRWLKNGAALVLEERTQIE----NGALTISNLS 377
Query: 106 GGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVV-VQEGAPLTLQCNP 164
G +QC A NK G S+ V+ +P + K + +V VQ G+ ++L C P
Sbjct: 378 ----VTDSGMFQCIAENKHGLVYSSAELKVVASAPDFSKNPMKKLVQVQVGSLVSLDCKP 433
Query: 165 PPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQ 224
P + W + + + +R+S ++G L +NV D T Y+C A F
Sbjct: 434 RAS-PRALSSWKKGDVS-VQEHERISLLNDGGLKIANVTKADAGT-YTCMAENQFG---- 486
Query: 225 QKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDI--AWYK 282
+ N T V+T E T + P S+ V G ++L C P DI WY
Sbjct: 487 KANGTTHLVVT-----EPTRITLAP----SNMDVSVGESVILPCQVQHDPLLDIIFTWYF 537
Query: 283 KGG--DLPSDKAKFENFNKA----LRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAA 336
G D D + FE + L I N+ + SG+Y C+ + S+ + V+ +
Sbjct: 538 NGALADFKKDGSHFEKVGGSSSGDLMIRNIQLKHSGKYVCMVQTGVDSVSSAADLIVRGS 597
Query: 337 P 337
P
Sbjct: 598 P 598
Score = 79.0 bits (193), Expect = 1e-14
Identities = 89/378 (23%), Positives = 154/378 (40%), Gaps = 42/378 (11%)
Query: 264 LLLECIASGVPTPDIAWYKKGGDLP-SDKAKFENFNKALRITNVSEE-DSGEYFCLASNK 321
+ L C A G P+P W G D+ S + +++ L + N + D+G Y C A+N
Sbjct: 46 ITLHCEARGNPSPHYRWQLNGSDIDMSMEHRYKLNGGNLVVINPNRNWDTGTYQCFATNS 105
Query: 322 MGSIRHTISVRVKAAPYWLDEPKNLI-----LAPGEDGRLVCRANGNPKP-----TVQWM 371
+G+I +S K +L+ K + + G+ L+C P P + W+
Sbjct: 106 LGTI---VSREAKLQFAYLENFKTKMRSTVSVREGQGVVLLC----GPPPHSGELSYAWI 158
Query: 372 VNGEPLQSAPPNPNREVAGDT--IIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVP 429
N P + R V+ +T + + S Y C ++ ++ NA V P
Sbjct: 159 FNEYP-SFVEEDSRRFVSQETGHLYISKVEPSDVGNYTCVVTS----MVTNARVLGSPTP 213
Query: 430 -------------PRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGG 476
P++ + + + +L+C G+PIP + W + G
Sbjct: 214 LVLRSDGVMGEYEPKIEVQFPETLPAAKGSTVKLECFALGNPIPQINW-RRSDGLPFSSK 272
Query: 477 NYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVARRG 536
+G LEI ++ED G Y C+A N GK + RL ++ +D
Sbjct: 273 IKLRKFSGVLEIPNFQQEDAGSYECIAENSRGKNVARGRLTYYAKPHWVQLIKDVEIAVE 332
Query: 537 TTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAERDQGSYTCVAST 596
++ ECR P K + WLK+ L + R + E+ +LTI ++ D G + C+A
Sbjct: 333 DSLYWECRASGKP--KPSYRWLKNGAALVLEERTQIENGALTISNLSVTDSGMFQCIAEN 390
Query: 597 ELDQDLAKAYLTVLGNCP 614
+ + A L V+ + P
Sbjct: 391 KHGLVYSSAELKVVASAP 408
>gi|28373117 contactin 1 isoform 1 precursor [Homo sapiens]
Length = 1018
Score = 219 bits (559), Expect = 4e-57
Identities = 174/571 (30%), Positives = 250/571 (43%), Gaps = 47/571 (8%)
Query: 59 ILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYE--GEY 116
+ + C A+ +P P + W N+ ++ D R SM G LVI+ P++ + G Y
Sbjct: 61 VSLNCRARASPFPVYKWRMNNGDVDLTSD-RYSMV--GGNLVIN-----NPDKQKDAGIY 112
Query: 117 QCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIF-W 175
C A N +G S L +P E V V+EG + L C+PP P + + W
Sbjct: 113 YCLASNNYGMVRSTEATLSFGYLDPFPPEERPEVRVKEGKGMVLLCDPPYHFPDDLSYRW 172
Query: 176 MSSSMEP-ITQDKR--VSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLK 232
+ + IT DKR VSQ NG+LY +NV D + +YSC F + K
Sbjct: 173 LLNEFPVFITMDKRRFVSQT-NGNLYIANVEASD-KGNYSC-----FVSSPSITKSVFSK 225
Query: 233 VLTTRGVAERTPSFMYPQGTA---SSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPS 289
+ + ERT YP L G ++ LEC A G P PDI W K +PS
Sbjct: 226 FIPLIPIPERTTK-PYPADIVVQFKDVYALMGQNVTLECFALGNPVPDIRWRKVLEPMPS 284
Query: 290 DKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILA 349
A+ L+I N+ ED G Y C A N G +H + V+A P W++ + +
Sbjct: 285 T-AEISTSGAVLKIFNIQLEDEGIYECEAENIRGKDKHQARIYVQAFPEWVEHINDTEVD 343
Query: 350 PGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCN 409
G D C A G P PT++W+ NG G+ ++ D + +YQC
Sbjct: 344 IGSDLYWPCVATGKPIPTIRWLKNGYAYHK----------GELRLY-DVTFENAGMYQCI 392
Query: 410 TSNEHGYLLANAFVSVLDVPPRM-LSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNG 468
N +G + ANA + +L + P ++P + I R ++C +P P W K G
Sbjct: 393 AENTYGAIYANAELKILALAPTFEMNPMKKKILAAKGGRVIIECKPKAAPKPKFSWSK-G 451
Query: 469 QGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMP 528
++ ++E+GSLEI I + D GIYTC A N GKA + L + DPTRI P
Sbjct: 452 TEWLVNSSRILIWEDGSLEINNITRNDGGIYTCFAENNRGKANSTGTLVITDPTRIILAP 511
Query: 529 EDQVARRGTTVQLECRVKHDPSLKLTVSW--------LKDDEPLYIGNRMKKEDDSLTIF 580
+ G ++C DP+L LT W + Y N M + L I
Sbjct: 512 INADITVGENATMQCAASFDPALDLTFVWSFNGYVIDFNKENIHYQRNFMLDSNGELLIR 571
Query: 581 GVAERDQGSYTCVASTELDQDLAKAYLTVLG 611
+ G YTC A T +D A A L V G
Sbjct: 572 NAQLKHAGRYTCTAQTIVDNSSASADLVVRG 602
Score = 83.6 bits (205), Expect = 5e-16
Identities = 88/365 (24%), Positives = 149/365 (40%), Gaps = 30/365 (8%)
Query: 266 LECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEE-DSGEYFCLASNKMGS 324
L C A P P W GD+ ++ L I N ++ D+G Y+CLASN G
Sbjct: 63 LNCRARASPFPVYKWRMNNGDVDLTSDRYSMVGGNLVINNPDKQKDAGIYYCLASNNYGM 122
Query: 325 IRHTISVRVKAA--PYWLDEPKNLILAPGEDGRLVCRANGN--PKPTVQWMVNGEPLQSA 380
+R T + P+ +E + + G+ L+C + + +W++N P+
Sbjct: 123 VRSTEATLSFGYLDPFPPEERPEVRVKEGKGMVLLCDPPYHFPDDLSYRWLLNEFPV-FI 181
Query: 381 PPNPNREVA--GDTIIFRDTQISSRAVYQCNTSNEH-GYLLANAFVSVLDVPPRMLSPRN 437
+ R V+ + + + S + Y C S+ + + F+ ++ +P R P
Sbjct: 182 TMDKRRFVSQTNGNLYIANVEASDKGNYSCFVSSPSITKSVFSKFIPLIPIPERTTKPYP 241
Query: 438 QLIRV-------ILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGS-LEIK 489
I V ++ L+C G+P+P +RW K + + +G+ L+I
Sbjct: 242 ADIVVQFKDVYALMGQNVTLECFALGNPVPDIRWRKVLEPMP---STAEISTSGAVLKIF 298
Query: 490 MIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDP 549
I+ ED+GIY C A NI GK ++Q R+ V+ D G+ + C P
Sbjct: 299 NIQLEDEGIYECEAENIRGKDKHQARIYVQAFPEWVEHINDTEVDIGSDLYWPCVATGKP 358
Query: 550 SLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTV 609
T+ WLK+ + G L ++ V + G Y C+A A A L +
Sbjct: 359 IP--TIRWLKNGYAYHKGE--------LRLYDVTFENAGMYQCIAENTYGAIYANAELKI 408
Query: 610 LGNCP 614
L P
Sbjct: 409 LALAP 413
Score = 79.0 bits (193), Expect = 1e-14
Identities = 110/472 (23%), Positives = 179/472 (37%), Gaps = 59/472 (12%)
Query: 72 SFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNR 131
S+ W N I D R + + +G L I +G Y CF + T +
Sbjct: 169 SYRWLLNEFPVFITMDKRRFVSQTNGNLYI----ANVEASDKGNYSCFVSSPSIT--KSV 222
Query: 132 IRLQVSKSPLWPKENLDP----VVVQ-------EGAPLTLQCNPPPGLPSPVIFWMSSSM 180
+ P+ P+ P +VVQ G +TL+C G P P I W +
Sbjct: 223 FSKFIPLIPI-PERTTKPYPADIVVQFKDVYALMGQNVTLECFAL-GNPVPDIRWRKV-L 279
Query: 181 EPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRGVA 240
EP+ +S L N+ L+D + Y C A I+ K+ ++
Sbjct: 280 EPMPSTAEISTS-GAVLKIFNIQLED-EGIYECEAE-----NIRGKDKHQARIYV----- 327
Query: 241 ERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKA 300
+ P ++ + G DL C+A+G P P I W K G +
Sbjct: 328 QAFPEWVEHINDTEVDI---GSDLYWPCVATGKPIPTIRWLKNG---------YAYHKGE 375
Query: 301 LRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKA-APYWLDEPKNLILAPGEDGRLV-- 357
LR+ +V+ E++G Y C+A N G+I +++ A AP + P + + GR++
Sbjct: 376 LRLYDVTFENAGMYQCIAENTYGAIYANAELKILALAPTFEMNPMKKKILAAKGGRVIIE 435
Query: 358 CRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGD--TIIFRDTQISSRAVYQCNTSNEHG 415
C+ PKP W E L N +R + + ++ + + +Y C N G
Sbjct: 436 CKPKAAPKPKFSWSKGTEWLV----NSSRILIWEDGSLEINNITRNDGGIYTCFAENNRG 491
Query: 416 YLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDG 475
+ + + D +L+P N I V + F + T W NG + +
Sbjct: 492 KANSTGTLVITDPTRIILAPINADITVGENATMQCAASFDPALDLTFVWSFNGYVIDFNK 551
Query: 476 GNYHVYEN------GSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDP 521
N H N G L I+ + + G YTC A I+ + L V+ P
Sbjct: 552 ENIHYQRNFMLDSNGELLIRNAQLKHAGRYTCTAQTIVDNSSASADLVVRGP 603
Score = 76.3 bits (186), Expect = 8e-14
Identities = 89/383 (23%), Positives = 141/383 (36%), Gaps = 46/383 (12%)
Query: 40 PPTITKQSAKDHIVDPRD-------NILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSM 92
P TK D +V +D N+ +EC A GNP P W + + P +
Sbjct: 233 PERTTKPYPADIVVQFKDVYALMGQNVTLECFALGNPVPDIRWRK-----VLEPMPSTAE 287
Query: 93 RRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVV 152
SG ++ F E EG Y+C A N G ++ R+ V P W E+++ V
Sbjct: 288 ISTSGAVLKIFNI---QLEDEGIYECEAENIRGKD-KHQARIYVQAFPEW-VEHINDTEV 342
Query: 153 QEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYS 212
G+ L C G P P I W+ K H G+L +V ++ Y
Sbjct: 343 DIGSDLYWPC-VATGKPIPTIRWL----------KNGYAYHKGELRLYDVTFENAGM-YQ 390
Query: 213 CNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASG 272
C A + LK+L E P + +G +++EC
Sbjct: 391 CIAENTYGAIYANAE---LKILALAPTFEMNP-------MKKKILAAKGGRVIIECKPKA 440
Query: 273 VPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVR 332
P P +W K L + + +L I N++ D G Y C A N G T ++
Sbjct: 441 APKPKFSWSKGTEWLVNSSRILIWEDGSLEINNITRNDGGIYTCFAENNRGKANSTGTLV 500
Query: 333 VKAAPYWLDEPKNLILAPGEDGRLVCRANGNP--KPTVQWMVNGEPLQSAPPNPNRE--- 387
+ + P N + GE+ + C A+ +P T W NG + N + +
Sbjct: 501 ITDPTRIILAPINADITVGENATMQCAASFDPALDLTFVWSFNGYVIDFNKENIHYQRNF 560
Query: 388 --VAGDTIIFRDTQISSRAVYQC 408
+ ++ R+ Q+ Y C
Sbjct: 561 MLDSNGELLIRNAQLKHAGRYTC 583
Score = 50.8 bits (120), Expect = 4e-06
Identities = 40/160 (25%), Positives = 69/160 (43%), Gaps = 8/160 (5%)
Query: 444 LYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVA 503
L + L+C SP P +W N +L Y + + +++D GIY C+A
Sbjct: 57 LEGKVSLNCRARASPFPVYKWRMNNGDVDLTSDRYSMVGGNLVINNPDKQKDAGIYYCLA 116
Query: 504 TNILG---KAENQVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKD 560
+N G E + DP PE +V + G + L C + L+ WL +
Sbjct: 117 SNNYGMVRSTEATLSFGYLDPFPPEERPEVRV-KEGKGMVLLCDPPYHFPDDLSYRWLLN 175
Query: 561 DEPLYI----GNRMKKEDDSLTIFGVAERDQGSYTCVAST 596
+ P++I + + + +L I V D+G+Y+C S+
Sbjct: 176 EFPVFITMDKRRFVSQTNGNLYIANVEASDKGNYSCFVSS 215
>gi|28373119 contactin 1 isoform 2 precursor [Homo sapiens]
Length = 1007
Score = 219 bits (559), Expect = 4e-57
Identities = 174/571 (30%), Positives = 250/571 (43%), Gaps = 47/571 (8%)
Query: 59 ILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYE--GEY 116
+ + C A+ +P P + W N+ ++ D R SM G LVI+ P++ + G Y
Sbjct: 50 VSLNCRARASPFPVYKWRMNNGDVDLTSD-RYSMV--GGNLVIN-----NPDKQKDAGIY 101
Query: 117 QCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIF-W 175
C A N +G S L +P E V V+EG + L C+PP P + + W
Sbjct: 102 YCLASNNYGMVRSTEATLSFGYLDPFPPEERPEVRVKEGKGMVLLCDPPYHFPDDLSYRW 161
Query: 176 MSSSMEP-ITQDKR--VSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLK 232
+ + IT DKR VSQ NG+LY +NV D + +YSC F + K
Sbjct: 162 LLNEFPVFITMDKRRFVSQT-NGNLYIANVEASD-KGNYSC-----FVSSPSITKSVFSK 214
Query: 233 VLTTRGVAERTPSFMYPQGTA---SSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPS 289
+ + ERT YP L G ++ LEC A G P PDI W K +PS
Sbjct: 215 FIPLIPIPERTTK-PYPADIVVQFKDVYALMGQNVTLECFALGNPVPDIRWRKVLEPMPS 273
Query: 290 DKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILA 349
A+ L+I N+ ED G Y C A N G +H + V+A P W++ + +
Sbjct: 274 T-AEISTSGAVLKIFNIQLEDEGIYECEAENIRGKDKHQARIYVQAFPEWVEHINDTEVD 332
Query: 350 PGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCN 409
G D C A G P PT++W+ NG G+ ++ D + +YQC
Sbjct: 333 IGSDLYWPCVATGKPIPTIRWLKNGYAYHK----------GELRLY-DVTFENAGMYQCI 381
Query: 410 TSNEHGYLLANAFVSVLDVPPRM-LSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNG 468
N +G + ANA + +L + P ++P + I R ++C +P P W K G
Sbjct: 382 AENTYGAIYANAELKILALAPTFEMNPMKKKILAAKGGRVIIECKPKAAPKPKFSWSK-G 440
Query: 469 QGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMP 528
++ ++E+GSLEI I + D GIYTC A N GKA + L + DPTRI P
Sbjct: 441 TEWLVNSSRILIWEDGSLEINNITRNDGGIYTCFAENNRGKANSTGTLVITDPTRIILAP 500
Query: 529 EDQVARRGTTVQLECRVKHDPSLKLTVSW--------LKDDEPLYIGNRMKKEDDSLTIF 580
+ G ++C DP+L LT W + Y N M + L I
Sbjct: 501 INADITVGENATMQCAASFDPALDLTFVWSFNGYVIDFNKENIHYQRNFMLDSNGELLIR 560
Query: 581 GVAERDQGSYTCVASTELDQDLAKAYLTVLG 611
+ G YTC A T +D A A L V G
Sbjct: 561 NAQLKHAGRYTCTAQTIVDNSSASADLVVRG 591
Score = 83.6 bits (205), Expect = 5e-16
Identities = 88/365 (24%), Positives = 149/365 (40%), Gaps = 30/365 (8%)
Query: 266 LECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEE-DSGEYFCLASNKMGS 324
L C A P P W GD+ ++ L I N ++ D+G Y+CLASN G
Sbjct: 52 LNCRARASPFPVYKWRMNNGDVDLTSDRYSMVGGNLVINNPDKQKDAGIYYCLASNNYGM 111
Query: 325 IRHTISVRVKAA--PYWLDEPKNLILAPGEDGRLVCRANGN--PKPTVQWMVNGEPLQSA 380
+R T + P+ +E + + G+ L+C + + +W++N P+
Sbjct: 112 VRSTEATLSFGYLDPFPPEERPEVRVKEGKGMVLLCDPPYHFPDDLSYRWLLNEFPV-FI 170
Query: 381 PPNPNREVA--GDTIIFRDTQISSRAVYQCNTSNEH-GYLLANAFVSVLDVPPRMLSPRN 437
+ R V+ + + + S + Y C S+ + + F+ ++ +P R P
Sbjct: 171 TMDKRRFVSQTNGNLYIANVEASDKGNYSCFVSSPSITKSVFSKFIPLIPIPERTTKPYP 230
Query: 438 QLIRV-------ILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGS-LEIK 489
I V ++ L+C G+P+P +RW K + + +G+ L+I
Sbjct: 231 ADIVVQFKDVYALMGQNVTLECFALGNPVPDIRWRKVLEPMP---STAEISTSGAVLKIF 287
Query: 490 MIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDP 549
I+ ED+GIY C A NI GK ++Q R+ V+ D G+ + C P
Sbjct: 288 NIQLEDEGIYECEAENIRGKDKHQARIYVQAFPEWVEHINDTEVDIGSDLYWPCVATGKP 347
Query: 550 SLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTV 609
T+ WLK+ + G L ++ V + G Y C+A A A L +
Sbjct: 348 IP--TIRWLKNGYAYHKGE--------LRLYDVTFENAGMYQCIAENTYGAIYANAELKI 397
Query: 610 LGNCP 614
L P
Sbjct: 398 LALAP 402
Score = 79.0 bits (193), Expect = 1e-14
Identities = 110/472 (23%), Positives = 179/472 (37%), Gaps = 59/472 (12%)
Query: 72 SFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNR 131
S+ W N I D R + + +G L I +G Y CF + T +
Sbjct: 158 SYRWLLNEFPVFITMDKRRFVSQTNGNLYI----ANVEASDKGNYSCFVSSPSIT--KSV 211
Query: 132 IRLQVSKSPLWPKENLDP----VVVQ-------EGAPLTLQCNPPPGLPSPVIFWMSSSM 180
+ P+ P+ P +VVQ G +TL+C G P P I W +
Sbjct: 212 FSKFIPLIPI-PERTTKPYPADIVVQFKDVYALMGQNVTLECFAL-GNPVPDIRWRKV-L 268
Query: 181 EPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRGVA 240
EP+ +S L N+ L+D + Y C A I+ K+ ++
Sbjct: 269 EPMPSTAEISTS-GAVLKIFNIQLED-EGIYECEAE-----NIRGKDKHQARIYV----- 316
Query: 241 ERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKA 300
+ P ++ + G DL C+A+G P P I W K G +
Sbjct: 317 QAFPEWVEHINDTEVDI---GSDLYWPCVATGKPIPTIRWLKNG---------YAYHKGE 364
Query: 301 LRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKA-APYWLDEPKNLILAPGEDGRLV-- 357
LR+ +V+ E++G Y C+A N G+I +++ A AP + P + + GR++
Sbjct: 365 LRLYDVTFENAGMYQCIAENTYGAIYANAELKILALAPTFEMNPMKKKILAAKGGRVIIE 424
Query: 358 CRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGD--TIIFRDTQISSRAVYQCNTSNEHG 415
C+ PKP W E L N +R + + ++ + + +Y C N G
Sbjct: 425 CKPKAAPKPKFSWSKGTEWLV----NSSRILIWEDGSLEINNITRNDGGIYTCFAENNRG 480
Query: 416 YLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDG 475
+ + + D +L+P N I V + F + T W NG + +
Sbjct: 481 KANSTGTLVITDPTRIILAPINADITVGENATMQCAASFDPALDLTFVWSFNGYVIDFNK 540
Query: 476 GNYHVYEN------GSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDP 521
N H N G L I+ + + G YTC A I+ + L V+ P
Sbjct: 541 ENIHYQRNFMLDSNGELLIRNAQLKHAGRYTCTAQTIVDNSSASADLVVRGP 592
Score = 76.3 bits (186), Expect = 8e-14
Identities = 89/383 (23%), Positives = 141/383 (36%), Gaps = 46/383 (12%)
Query: 40 PPTITKQSAKDHIVDPRD-------NILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSM 92
P TK D +V +D N+ +EC A GNP P W + + P +
Sbjct: 222 PERTTKPYPADIVVQFKDVYALMGQNVTLECFALGNPVPDIRWRK-----VLEPMPSTAE 276
Query: 93 RRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVV 152
SG ++ F E EG Y+C A N G ++ R+ V P W E+++ V
Sbjct: 277 ISTSGAVLKIFNI---QLEDEGIYECEAENIRGKD-KHQARIYVQAFPEW-VEHINDTEV 331
Query: 153 QEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYS 212
G+ L C G P P I W+ K H G+L +V ++ Y
Sbjct: 332 DIGSDLYWPC-VATGKPIPTIRWL----------KNGYAYHKGELRLYDVTFENAGM-YQ 379
Query: 213 CNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASG 272
C A + LK+L E P + +G +++EC
Sbjct: 380 CIAENTYGAIYANAE---LKILALAPTFEMNP-------MKKKILAAKGGRVIIECKPKA 429
Query: 273 VPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVR 332
P P +W K L + + +L I N++ D G Y C A N G T ++
Sbjct: 430 APKPKFSWSKGTEWLVNSSRILIWEDGSLEINNITRNDGGIYTCFAENNRGKANSTGTLV 489
Query: 333 VKAAPYWLDEPKNLILAPGEDGRLVCRANGNP--KPTVQWMVNGEPLQSAPPNPNRE--- 387
+ + P N + GE+ + C A+ +P T W NG + N + +
Sbjct: 490 ITDPTRIILAPINADITVGENATMQCAASFDPALDLTFVWSFNGYVIDFNKENIHYQRNF 549
Query: 388 --VAGDTIIFRDTQISSRAVYQC 408
+ ++ R+ Q+ Y C
Sbjct: 550 MLDSNGELLIRNAQLKHAGRYTC 572
Score = 50.8 bits (120), Expect = 4e-06
Identities = 40/160 (25%), Positives = 69/160 (43%), Gaps = 8/160 (5%)
Query: 444 LYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVA 503
L + L+C SP P +W N +L Y + + +++D GIY C+A
Sbjct: 46 LEGKVSLNCRARASPFPVYKWRMNNGDVDLTSDRYSMVGGNLVINNPDKQKDAGIYYCLA 105
Query: 504 TNILG---KAENQVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKD 560
+N G E + DP PE +V + G + L C + L+ WL +
Sbjct: 106 SNNYGMVRSTEATLSFGYLDPFPPEERPEVRV-KEGKGMVLLCDPPYHFPDDLSYRWLLN 164
Query: 561 DEPLYI----GNRMKKEDDSLTIFGVAERDQGSYTCVAST 596
+ P++I + + + +L I V D+G+Y+C S+
Sbjct: 165 EFPVFITMDKRRFVSQTNGNLYIANVEASDKGNYSCFVSS 204
>gi|7657361 contactin 6 [Homo sapiens]
Length = 1028
Score = 198 bits (503), Expect = 1e-50
Identities = 155/568 (27%), Positives = 238/568 (41%), Gaps = 26/568 (4%)
Query: 56 RDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGE 115
+ +++ C A G P+P + W +N + R G+L I+ ++ G
Sbjct: 43 KSEVILNCAANGYPSPHYRWKQNGTDIDFTMS--YHYRLDGGSLAIN---SPHTDQDIGM 97
Query: 116 YQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFW 175
YQC A N GT LS + +LQ + + + V V+EG + L C PPP W
Sbjct: 98 YQCLATNLLGTILSRKAKLQFAYIEDFETKTRSTVSVREGQGVVLLCGPPPHFGDLSYAW 157
Query: 176 MSSSMEPITQD--KRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKV 233
+ Q+ +R G+LY + V D+ +Y+C Q P L
Sbjct: 158 TFNDNPLYVQEDNRRFVSQETGNLYIAKVEPSDVG-NYTCFITNKEAQRSVQGPPTPLVQ 216
Query: 234 LTTRGVAERTPSF--MYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDK 291
T + E P +P+ ++ + + LEC A G P PDI+W + G K
Sbjct: 217 RTDGVMGEYEPKIEVRFPETIQAA----KDSSVKLECFALGNPVPDISWRRLDGSPLPGK 272
Query: 292 AKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPG 351
K+ L I N +ED G Y C+ASN G + A P W + +N L+
Sbjct: 273 VKYSKSQAILEIPNFQQEDEGFYECIASNLRGRNLAKGQLIFYAPPEWEQKIQNTHLSIY 332
Query: 352 EDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTS 411
++ C+A+G P P W+ NGE L P ++ T+I +S VYQC
Sbjct: 333 DNLLWECKASGKPNPWYTWLKNGERLN---PEERIQIENGTLIITMLNVSDSGVYQCAAE 389
Query: 412 NEHGYLLANAFVSVL-DVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQG 470
N++ + ANA + VL P SP + V + + C P + W K G
Sbjct: 390 NKYQIIYANAELRVLASAPDFSKSPVKKKSFVQVGGDIVIGCKPNAFPRAAISW-KRGTE 448
Query: 471 SNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPED 530
+ + E+GSL+I I + D G YTC+ATN G A+N L VK+ T I P
Sbjct: 449 TLRQSKRIFLLEDGSLKIYNITRSDAGSYTCIATNQFGTAKNTGSLIVKERTVITVPPSK 508
Query: 531 QVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMK-------KEDDSLTIFGVA 583
G ++ L C+V HDPS+++ W + + + + + + L I +
Sbjct: 509 MDVTVGESIVLPCQVSHDPSIEVVFVWFFNGDVIDLKKGVAHFERIGGESVGDLMIRNIQ 568
Query: 584 ERDQGSYTCVASTELDQDLAKAYLTVLG 611
G Y C T L+ A A + V G
Sbjct: 569 LHHSGKYLCTVQTTLESLSAVADIIVRG 596
Score = 90.9 bits (224), Expect = 3e-18
Identities = 93/377 (24%), Positives = 156/377 (41%), Gaps = 38/377 (10%)
Query: 263 DLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNV--SEEDSGEYFCLASN 320
+++L C A+G P+P W + G D+ + + N +++D G Y CLA+N
Sbjct: 45 EVILNCAANGYPSPHYRWKQNGTDIDFTMSYHYRLDGGSLAINSPHTDQDIGMYQCLATN 104
Query: 321 KMGSIRHTISVRVKAAPYWLD--EPKNLILAPGEDGRLVCRANGNPKP----TVQWMVNG 374
+G+I +S + K +++ E K +G+ V G P + W N
Sbjct: 105 LLGTI---LSRKAKLQFAYIEDFETKTRSTVSVREGQGVVLLCGPPPHFGDLSYAWTFND 161
Query: 375 EPLQSAPPNPNREVAGDT--IIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVL------ 426
PL N R V+ +T + + S Y C +N+ + L
Sbjct: 162 NPLYVQEDN-RRFVSQETGNLYIAKVEPSDVGNYTCFITNKEAQRSVQGPPTPLVQRTDG 220
Query: 427 ---DVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYEN 483
+ P++ + I+ + +L+C G+P+P + W + GS L G +
Sbjct: 221 VMGEYEPKIEVRFPETIQAAKDSSVKLECFALGNPVPDISW-RRLDGSPLPGKVKYSKSQ 279
Query: 484 GSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTVQL-- 541
LEI ++ED+G Y C+A+N+ G R K Y PE + + T + +
Sbjct: 280 AILEIPNFQQEDEGFYECIASNLRG------RNLAKGQLIFYAPPEWEQKIQNTHLSIYD 333
Query: 542 ----ECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAERDQGSYTCVASTE 597
EC+ P+ T WLK+ E L R++ E+ +L I + D G Y C A +
Sbjct: 334 NLLWECKASGKPNPWYT--WLKNGERLNPEERIQIENGTLIITMLNVSDSGVYQCAAENK 391
Query: 598 LDQDLAKAYLTVLGNCP 614
A A L VL + P
Sbjct: 392 YQIIYANAELRVLASAP 408
Score = 79.3 bits (194), Expect = 9e-15
Identities = 82/295 (27%), Positives = 119/295 (40%), Gaps = 43/295 (14%)
Query: 57 DNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEY 116
DN+L EC+A G P P + W +N N P ++ +GTL+I + G Y
Sbjct: 333 DNLLWECKASGKPNPWYTWLKNGERLN----PEERIQIENGTLIITMLNVSD----SGVY 384
Query: 117 QCFARNKFGTALSN-RIRL-----QVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPS 170
QC A NK+ +N +R+ SKSP+ K VQ G + + C P P
Sbjct: 385 QCAAENKYQIIYANAELRVLASAPDFSKSPVKKKS-----FVQVGGDIVIGCKPN-AFPR 438
Query: 171 PVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFT 230
I W + E + Q KR+ +G L N+ D + Y+C A F T
Sbjct: 439 AAISWKRGT-ETLRQSKRIFLLEDGSLKIYNITRSDAGS-YTCIATNQFG---------T 487
Query: 231 LKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIA--WYKKGG--D 286
K + V ERT + P S V G ++L C S P+ ++ W+ G D
Sbjct: 488 AKNTGSLIVKERTVITVPP----SKMDVTVGESIVLPCQVSHDPSIEVVFVWFFNGDVID 543
Query: 287 LPSDKAKFENFNKA----LRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAP 337
L A FE L I N+ SG+Y C + S+ + V+ P
Sbjct: 544 LKKGVAHFERIGGESVGDLMIRNIQLHHSGKYLCTVQTTLESLSAVADIIVRGPP 598
>gi|61888896 roundabout, axon guidance receptor, homolog 2 isoform
ROBO2b [Homo sapiens]
Length = 1378
Score = 194 bits (494), Expect = 2e-49
Identities = 156/518 (30%), Positives = 232/518 (44%), Gaps = 35/518 (6%)
Query: 19 LSLGGAIEIPMDPSIQNELTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRN 78
L L G + + +D S + PP I + + D IV + + C+A+G P P+ W ++
Sbjct: 9 LLLCGFLYVRVDGSRLRQEDFPPRIVEHPS-DVIVSKGEPTTLNCKAEGRPTPTIEWYKD 67
Query: 79 SRFFNIAKDPRVSMRRR--SGTLV-IDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQ 135
KD S R SG+L + G R + EG Y C ARN G A+S L+
Sbjct: 68 GERVETDKDDPRSHRMLLPSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLE 127
Query: 136 VSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNG 195
V+ ++N VVV G P L+C PP G P P I+W + +++R+S G
Sbjct: 128 VALLRDDFRQNPTDVVVAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISI-RGG 186
Query: 196 DLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASS 255
L SN D Y+C T+ + +++ ++ V ER P+F+ +
Sbjct: 187 KLMISNTRKSDAGM-YTCVG----TNMVGERDSDPAELT----VFER-PTFLR---RPIN 233
Query: 256 QMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYF 315
Q+VL + C G P P + W K DLP + ++ + LRI D G Y
Sbjct: 234 QVVLEEEAVEFRCQVQGDPQPTVRWKKDDADLPRGRYDIKD-DYTLRIKKTMSTDEGTYM 292
Query: 316 CLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGE 375
C+A N++G + + ++ V+A P ++ P++ I+A G C GNP+P V W G
Sbjct: 293 CIAENRVGKMEASATLTVRAPPQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGS 352
Query: 376 -----PLQSAPPNPNREVA--GDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDV 428
P Q PN V+ GD I + Q S Y C G +LA A + V DV
Sbjct: 353 QNLLFPNQPQQPNSRCSVSPTGDLTI-TNIQRSDAGYYICQALTVAGSILAKAQLEVTDV 411
Query: 429 -----PPRML-SPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYE 482
PP +L P NQ + V L C G P+P + W K G + E
Sbjct: 412 LTDRPPPIILQGPANQTLAV--DGTALLKCKATGDPLPVISWLKEGFTFPGRDPRATIQE 469
Query: 483 NGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKD 520
G+L+IK +R D G YTCVAT+ G+ L+V +
Sbjct: 470 QGTLQIKNLRISDTGTYTCVATSSSGETSWSAVLDVTE 507
Score = 139 bits (349), Expect = 1e-32
Identities = 108/379 (28%), Positives = 172/379 (45%), Gaps = 31/379 (8%)
Query: 254 SSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNV------- 306
S +V +G L C A G PTP I WYK G + +DK + L ++
Sbjct: 38 SDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSLFFLRIVH 97
Query: 307 ---SEEDSGEYFCLASNKMG-SIRHTISVRVKAA-PYWLDEPKNLILAPGEDGRLVCRA- 360
S+ D G Y C+A N +G ++ S+ V + P ++++A GE L C+
Sbjct: 98 GRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGEPAILECQPP 157
Query: 361 NGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLAN 420
G+P+PT+ W + ++ + G ++ +T+ S +Y C +N G ++
Sbjct: 158 RGHPEPTIYW--KKDKVRIDDKEERISIRGGKLMISNTRKSDAGMYTCVGTNMVGERDSD 215
Query: 421 -AFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYH 479
A ++V + P + P NQ+ V+ C G P PT+RW K+ ++L G Y
Sbjct: 216 PAELTVFERPTFLRRPINQV--VLEEEAVEFRCQVQGDPQPTVRWKKDD--ADLPRGRYD 271
Query: 480 VYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTV 539
+ ++ +L IK D+G Y C+A N +GK E L V+ P + P DQ+ +G TV
Sbjct: 272 IKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRPRDQIVAQGRTV 331
Query: 540 QLECRVKHDPSLKLTVSWLKD-DEPLYIGNRMKKEDD--------SLTIFGVAERDQGSY 590
C K +P + V W K+ + L N+ ++ + LTI + D G Y
Sbjct: 332 TFPCETKGNP--QPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDAGYY 389
Query: 591 TCVASTELDQDLAKAYLTV 609
C A T LAKA L V
Sbjct: 390 ICQALTVAGSILAKAQLEV 408
Score = 135 bits (340), Expect = 1e-31
Identities = 132/505 (26%), Positives = 208/505 (41%), Gaps = 50/505 (9%)
Query: 133 RLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQG 192
RL+ P E+ V+V +G P TL C G P+P I W E + DK +
Sbjct: 23 RLRQEDFPPRIVEHPSDVIVSKGEPTTLNCKAE-GRPTPTIEWYKDG-ERVETDKDDPRS 80
Query: 193 H-----NGDLYFSNVM----LQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRGVAERT 243
H +G L+F ++ + + Y C AR + + + +L+V R +
Sbjct: 81 HRMLLPSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNA--SLEVALLRDDFRQN 138
Query: 244 PSFMYPQGTASSQMVLRGMDLLLECIAS-GVPTPDIAWYKKGGDLPSDKAKFENFNKALR 302
P+ + +V G +LEC G P P I W K + + + L
Sbjct: 139 PTDV---------VVAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLM 189
Query: 303 ITNVSEEDSGEYFCLASNKMGSI-RHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRAN 361
I+N + D+G Y C+ +N +G + V P +L P N ++ E C+
Sbjct: 190 ISNTRKSDAGMYTCVGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQ 249
Query: 362 GNPKPTVQWMVNGEPLQSAPPNPNREVAGD-TIIFRDTQISSRAVYQCNTSNEHGYLLAN 420
G+P+PTV+W + L P ++ D T+ + T + Y C N G + A+
Sbjct: 250 GDPQPTVRWKKDDADL----PRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEAS 305
Query: 421 AFVSVLDVPPRMLSPRNQLIRVILYNRT-RLDCPFFGSPIPTLRWFKNGQGSNL------ 473
A ++V P ++ PR+Q ++ RT C G+P P + W K G + L
Sbjct: 306 ATLTVRAPPQFVVRPRDQ---IVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQ 362
Query: 474 -DGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKD------PTRIYR 526
V G L I I++ D G Y C A + G + +LEV D P I +
Sbjct: 363 QPNSRCSVSPTGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQ 422
Query: 527 MPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDE--PLYIGNRMKKEDDSLTIFGVAE 584
P +Q T L+C+ DP +SWLK+ P +E +L I +
Sbjct: 423 GPANQTLAVDGTALLKCKATGDPLP--VISWLKEGFTFPGRDPRATIQEQGTLQIKNLRI 480
Query: 585 RDQGSYTCVASTELDQDLAKAYLTV 609
D G+YTCVA++ + A L V
Sbjct: 481 SDTGTYTCVATSSSGETSWSAVLDV 505
>gi|193083163 roundabout, axon guidance receptor, homolog 2 isoform
ROBO2a [Homo sapiens]
Length = 1394
Score = 192 bits (487), Expect = 1e-48
Identities = 151/497 (30%), Positives = 223/497 (44%), Gaps = 35/497 (7%)
Query: 40 PPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRR--SG 97
PP I + + D IV + + C+A+G P P+ W ++ KD S R SG
Sbjct: 46 PPRIVEHPS-DVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSG 104
Query: 98 TLV-IDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGA 156
+L + G R + EG Y C ARN G A+S L+V+ ++N VVV G
Sbjct: 105 SLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGE 164
Query: 157 PLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNAR 216
P L+C PP G P P I+W + +++R+S G L SN D Y+C
Sbjct: 165 PAILECQPPRGHPEPTIYWKKDKVRIDDKEERISI-RGGKLMISNTRKSDAGM-YTCVG- 221
Query: 217 FHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTP 276
T+ + +++ ++ V ER P+F+ +Q+VL + C G P P
Sbjct: 222 ---TNMVGERDSDPAELT----VFER-PTFLR---RPINQVVLEEEAVEFRCQVQGDPQP 270
Query: 277 DIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAA 336
+ W K DLP + ++ + LRI D G Y C+A N++G + + ++ V+A
Sbjct: 271 TVRWKKDDADLPRGRYDIKD-DYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAP 329
Query: 337 PYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGE-----PLQSAPPNPNREVA-- 389
P ++ P++ I+A G C GNP+P V W G P Q PN V+
Sbjct: 330 PQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPT 389
Query: 390 GDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDV-----PPRML-SPRNQLIRVI 443
GD I + Q S Y C G +LA A + V DV PP +L P NQ + V
Sbjct: 390 GDLTI-TNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAV- 447
Query: 444 LYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVA 503
L C G P+P + W K G + E G+L+IK +R D G YTCVA
Sbjct: 448 -DGTALLKCKATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVA 506
Query: 504 TNILGKAENQVRLEVKD 520
T+ G+ L+V +
Sbjct: 507 TSSSGETSWSAVLDVTE 523
Score = 139 bits (349), Expect = 1e-32
Identities = 108/379 (28%), Positives = 172/379 (45%), Gaps = 31/379 (8%)
Query: 254 SSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNV------- 306
S +V +G L C A G PTP I WYK G + +DK + L ++
Sbjct: 54 SDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSLFFLRIVH 113
Query: 307 ---SEEDSGEYFCLASNKMG-SIRHTISVRVKAA-PYWLDEPKNLILAPGEDGRLVCRA- 360
S+ D G Y C+A N +G ++ S+ V + P ++++A GE L C+
Sbjct: 114 GRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGEPAILECQPP 173
Query: 361 NGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLAN 420
G+P+PT+ W + ++ + G ++ +T+ S +Y C +N G ++
Sbjct: 174 RGHPEPTIYW--KKDKVRIDDKEERISIRGGKLMISNTRKSDAGMYTCVGTNMVGERDSD 231
Query: 421 -AFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYH 479
A ++V + P + P NQ+ V+ C G P PT+RW K+ ++L G Y
Sbjct: 232 PAELTVFERPTFLRRPINQV--VLEEEAVEFRCQVQGDPQPTVRWKKDD--ADLPRGRYD 287
Query: 480 VYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTV 539
+ ++ +L IK D+G Y C+A N +GK E L V+ P + P DQ+ +G TV
Sbjct: 288 IKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRPRDQIVAQGRTV 347
Query: 540 QLECRVKHDPSLKLTVSWLKD-DEPLYIGNRMKKEDD--------SLTIFGVAERDQGSY 590
C K +P + V W K+ + L N+ ++ + LTI + D G Y
Sbjct: 348 TFPCETKGNP--QPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDAGYY 405
Query: 591 TCVASTELDQDLAKAYLTV 609
C A T LAKA L V
Sbjct: 406 ICQALTVAGSILAKAQLEV 424
Score = 135 bits (340), Expect = 1e-31
Identities = 132/505 (26%), Positives = 208/505 (41%), Gaps = 50/505 (9%)
Query: 133 RLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQG 192
RL+ P E+ V+V +G P TL C G P+P I W E + DK +
Sbjct: 39 RLRQEDFPPRIVEHPSDVIVSKGEPTTLNCKAE-GRPTPTIEWYKDG-ERVETDKDDPRS 96
Query: 193 H-----NGDLYFSNVM----LQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRGVAERT 243
H +G L+F ++ + + Y C AR + + + +L+V R +
Sbjct: 97 HRMLLPSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNA--SLEVALLRDDFRQN 154
Query: 244 PSFMYPQGTASSQMVLRGMDLLLECIAS-GVPTPDIAWYKKGGDLPSDKAKFENFNKALR 302
P+ + +V G +LEC G P P I W K + + + L
Sbjct: 155 PTDV---------VVAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLM 205
Query: 303 ITNVSEEDSGEYFCLASNKMGSI-RHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRAN 361
I+N + D+G Y C+ +N +G + V P +L P N ++ E C+
Sbjct: 206 ISNTRKSDAGMYTCVGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQ 265
Query: 362 GNPKPTVQWMVNGEPLQSAPPNPNREVAGD-TIIFRDTQISSRAVYQCNTSNEHGYLLAN 420
G+P+PTV+W + L P ++ D T+ + T + Y C N G + A+
Sbjct: 266 GDPQPTVRWKKDDADL----PRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEAS 321
Query: 421 AFVSVLDVPPRMLSPRNQLIRVILYNRT-RLDCPFFGSPIPTLRWFKNGQGSNL------ 473
A ++V P ++ PR+Q ++ RT C G+P P + W K G + L
Sbjct: 322 ATLTVRAPPQFVVRPRDQ---IVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQ 378
Query: 474 -DGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKD------PTRIYR 526
V G L I I++ D G Y C A + G + +LEV D P I +
Sbjct: 379 QPNSRCSVSPTGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQ 438
Query: 527 MPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDE--PLYIGNRMKKEDDSLTIFGVAE 584
P +Q T L+C+ DP +SWLK+ P +E +L I +
Sbjct: 439 GPANQTLAVDGTALLKCKATGDPLP--VISWLKEGFTFPGRDPRATIQEQGTLQIKNLRI 496
Query: 585 RDQGSYTCVASTELDQDLAKAYLTV 609
D G+YTCVA++ + A L V
Sbjct: 497 SDTGTYTCVATSSSGETSWSAVLDV 521
Score = 40.0 bits (92), Expect = 0.006
Identities = 33/139 (23%), Positives = 61/139 (43%), Gaps = 9/139 (6%)
Query: 12 AAFLLC-LLSLGGAIEIPMDPSIQNELT-QPPTITKQSAKDHIVDPRDNILIECEAKGNP 69
A + +C L++ G+I + + LT +PP I Q + + L++C+A G+P
Sbjct: 402 AGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKCKATGDP 461
Query: 70 APSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALS 129
P W + F +DPR +++ + + + R G Y C A + G
Sbjct: 462 LPVISWLKEGFTFP-GRDPRATIQEQGTLQIKNLRISD-----TGTYTCVATSSSGETSW 515
Query: 130 NRIRLQVSKSPLWPKENLD 148
+ + L V++S +N D
Sbjct: 516 SAV-LDVTESGATISKNYD 533
>gi|48476182 roundabout, axon guidance receptor, homolog 3 [Homo
sapiens]
Length = 1386
Score = 184 bits (466), Expect = 3e-46
Identities = 151/512 (29%), Positives = 231/512 (45%), Gaps = 37/512 (7%)
Query: 18 LLSLGGAIEIPMDPSIQNELTQP----PTITKQSAKDHIVDPRDNILIECEAKGNPAPSF 73
L +L + P DPS+ P P I +Q D +V + + C A+G P P+
Sbjct: 37 LAALNHTLLPPGDPSLNGSRVGPEDAMPRIVEQPP-DLLVSRGEPATLPCRAEGRPRPNI 95
Query: 74 HWTRN-SRFFNIAKDPRVS-MRRRSGTLVID-FRSGGRPEEYEGEYQCFARNKFGTALSN 130
W +N +R + +DPR + SG L G R EG Y C ARN G A S
Sbjct: 96 EWYKNGARVATVREDPRAHRLLLPSGALFFPRIVHGRRARPDEGVYTCVARNYLGAAASR 155
Query: 131 RIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVS 190
L+V+ +++ VVV G P L+C PP G P P + W ++ R++
Sbjct: 156 NASLEVAVLRDDFRQSPGNVVVAVGEPAVLECVPPRGHPEPSVSWRKDGARLKEEEGRIT 215
Query: 191 QGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQ 250
G L S+ + D Y C A ++ ++ +V+ V ER PSF+
Sbjct: 216 I-RGGKLMMSHTLKSDAGM-YVCVA----SNMAGERESAAAEVM----VLER-PSFLR-- 262
Query: 251 GTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEED 310
+Q+VL + C G P P + W K+ G+LP+ + + + + +L I +VS ED
Sbjct: 263 -RPVNQVVLADAPVTFLCEVKGDPPPRLRWRKEDGELPTGRYEIRS-DHSLWIGHVSAED 320
Query: 311 SGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQW 370
G Y C+A N +G + S+ V P + +P++ + APGE C GNP P + W
Sbjct: 321 EGTYTCVAENSVGRAEASGSLSVHVPPQLVTQPQDQMAAPGESVAFQCETKGNPPPAIFW 380
Query: 371 MVNGE-----PLQSAPPNPNREVAG-DTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVS 424
G P QS P V+ + Q Y C + G +LA A +
Sbjct: 381 QKEGSQVLLFPSQSLQPTGRFSVSPRGQLNITAVQRGDAGYYVCQAVSVAGSILAKALLE 440
Query: 425 V----LD-VPPRMLS-PRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNY 478
+ LD +PP +L P NQ + +L + L C G+P P++RW K+GQ D +
Sbjct: 441 IKGASLDGLPPVILQGPANQTL--VLGSSVWLPCRVTGNPQPSVRWKKDGQWLQGDDLQF 498
Query: 479 HVYENGSLEIKMIRKEDQGIYTCVATNILGKA 510
NG+L I +++ D G Y+CVA + G+A
Sbjct: 499 KTMANGTLYIANVQEMDMGFYSCVAKSSTGEA 530
Score = 134 bits (337), Expect = 2e-31
Identities = 116/383 (30%), Positives = 160/383 (41%), Gaps = 41/383 (10%)
Query: 257 MVLRGMDLLLECIASGVPTPDIAWYKKGGD--------------LPSDKAKFENFNKALR 302
+V RG L C A G P P+I WYK G LPS F R
Sbjct: 74 LVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHRLLLPSGALFFPRIVHGRR 133
Query: 303 ITNVSEEDSGEYFCLASNKMG---SIRHTISVRVKAAPYWLDEPKNLILAPGEDGRLVC- 358
+ D G Y C+A N +G S ++ V V + P N+++A GE L C
Sbjct: 134 ----ARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDF-RQSPGNVVVAVGEPAVLECV 188
Query: 359 RANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYL- 417
G+P+P+V W +G L+ + G ++ T S +Y C SN G
Sbjct: 189 PPRGHPEPSVSWRKDGARLKEEEGRIT--IRGGKLMMSHTLKSDAGMYVCVASNMAGERE 246
Query: 418 LANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGN 477
A A V VL+ P + P NQ+ V+ C G P P LRW K + L G
Sbjct: 247 SAAAEVMVLERPSFLRRPVNQV--VLADAPVTFLCEVKGDPPPRLRWRK--EDGELPTGR 302
Query: 478 YHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVARRGT 537
Y + + SL I + ED+G YTCVA N +G+AE L V P ++ P+DQ+A G
Sbjct: 303 YEIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPPQLVTQPQDQMAAPGE 362
Query: 538 TVQLECRVKHDPSLKLTVSWLKDDEPLYI---------GNRMKKEDDSLTIFGVAERDQG 588
+V +C K +P + W K+ + + G L I V D G
Sbjct: 363 SVAFQCETKGNP--PPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNITAVQRGDAG 420
Query: 589 SYTCVASTELDQDLAKAYLTVLG 611
Y C A + LAKA L + G
Sbjct: 421 YYVCQAVSVAGSILAKALLEIKG 443
Score = 128 bits (321), Expect = 2e-29
Identities = 126/495 (25%), Positives = 207/495 (41%), Gaps = 48/495 (9%)
Query: 150 VVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPIT--QDKRVSQG--HNGDLYFSNVM-- 203
++V G P TL C G P P I W + T +D R + +G L+F ++
Sbjct: 73 LLVSRGEPATLPCRAE-GRPRPNIEWYKNGARVATVREDPRAHRLLLPSGALFFPRIVHG 131
Query: 204 --LQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRG 261
+ + Y+C AR ++ +N +L+V R ++P + +V G
Sbjct: 132 RRARPDEGVYTCVAR-NYLGAAASRNA-SLEVAVLRDDFRQSPG---------NVVVAVG 180
Query: 262 MDLLLECIAS-GVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASN 320
+LEC+ G P P ++W K G L ++ + L +++ + D+G Y C+ASN
Sbjct: 181 EPAVLECVPPRGHPEPSVSWRKDGARLKEEEGRITIRGGKLMMSHTLKSDAGMYVCVASN 240
Query: 321 KMGSIRHTIS-VRVKAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQS 379
G + V V P +L P N ++ +C G+P P ++W L
Sbjct: 241 MAGERESAAAEVMVLERPSFLRRPVNQVVLADAPVTFLCEVKGDPPPRLRWRKEDGEL-- 298
Query: 380 APPNPNREVAGD-TIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLS-PRN 437
P E+ D ++ Y C N G A+ +SV VPP++++ P++
Sbjct: 299 --PTGRYEIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSV-HVPPQLVTQPQD 355
Query: 438 QLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNL-------DGGNYHVYENGSLEIKM 490
Q+ C G+P P + W K G L G + V G L I
Sbjct: 356 QMAAP--GESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNITA 413
Query: 491 IRKEDQGIYTCVATNILGKAENQVRLEVKD------PTRIYRMPEDQVARRGTTVQLECR 544
+++ D G Y C A ++ G + LE+K P I + P +Q G++V L CR
Sbjct: 414 VQRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQGPANQTLVLGSSVWLPCR 473
Query: 545 VKHDPSLKLTVSWLKDDEPLYIGNRMKKE--DDSLTIFGVAERDQGSYTCVASTELDQDL 602
V +P + +V W KD + L + K + +L I V E D G Y+CVA + +
Sbjct: 474 VTGNP--QPSVRWKKDGQWLQGDDLQFKTMANGTLYIANVQEMDMGFYSCVAKSSTGEAT 531
Query: 603 AKAYLTVLGNCPCSP 617
+L + + SP
Sbjct: 532 WSGWLKMREDWGVSP 546
>gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3783
Score = 182 bits (463), Expect = 6e-46
Identities = 165/587 (28%), Positives = 246/587 (41%), Gaps = 47/587 (8%)
Query: 40 PPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTR-NSRFFNIAKDPRVSMRRRSGT 98
PPTI D V +++ C + G PAP+ W++ ++ RVS SG
Sbjct: 2574 PPTIADDQT-DFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLGARGSGYRVSP---SGA 2629
Query: 99 LVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLW-PKENLDPVVVQEGAP 157
L I G + G Y C ARN G A + L V SP+ P ++ V +E
Sbjct: 2630 LEI----GQALPIHAGRYTCSARNSAGVA-HKHVFLTVQASPVVKPLPSVVRAVAEEEVL 2684
Query: 158 LTLQCNPPPGLPSPVIFWMSSSMEPITQ-DKRVSQGHNGDLYFSNVMLQDMQTDYSCNAR 216
L + + G+P P I W + T +V G G L ++ +D +Y C A
Sbjct: 2685 LPCEAS---GIPRPTITWQKEGLNVATGVSTQVLPG--GQLRIAHASPEDAG-NYLCIA- 2737
Query: 217 FHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTP 276
KN + TR V + P + G L C A G P P
Sbjct: 2738 ---------KNSAGSAMGKTRLVVQVPPVI---ENGLPDLSTTEGSHAFLPCKARGSPEP 2785
Query: 277 DIAWYKKGGDLPSDKAKFE-NFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKA 335
+I W K G + + KF + L + N+ +D+G Y C A N +G R + + +
Sbjct: 2786 NITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRARRRVHLTILV 2845
Query: 336 APYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIF 395
P + P + L G+ L C A G+P P + W VN P+ + + G T+
Sbjct: 2846 LPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEGV---SEQDGGSTLQR 2902
Query: 396 RDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFF 455
Y C N G A +FV V + P + L+ + +LDC
Sbjct: 2903 AAVSREDSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPV-GGSIQLDCVVR 2961
Query: 456 GSPIPTLRWFKNG---QGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAEN 512
G P+P + W K+G +GS+L H +NGSL I+ ++D G Y C+A N +G A+
Sbjct: 2962 GDPVPDIHWIKDGLPLRGSHLR----HQLQNGSLTIRRTERDDAGRYQCLAENEMGVAKK 3017
Query: 513 QVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKK 572
V L ++ P+D R G V L C+ +P+ T+ WL+ +PL R++
Sbjct: 3018 VVILVLQSAPVFQVEPQDMTVRSGDDVALRCQATGEPT--PTIEWLQAGQPLRASRRLRT 3075
Query: 573 -EDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTVLGNCPCSPW 618
D SL + V D G+Y CVA L A+A+L V G P W
Sbjct: 3076 LPDGSLWLENVETGDAGTYDCVAHNLLGSATARAFLVVRGE-PQGSW 3121
Score = 157 bits (396), Expect = 4e-38
Identities = 153/604 (25%), Positives = 252/604 (41%), Gaps = 55/604 (9%)
Query: 41 PTI---TKQSAKDHIVDPRDN-ILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRS 96
PTI + SA + + +N I + CEA P+P+ W ++ F +++ ++ +
Sbjct: 1255 PTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGAPFEASRNIQL-LPGTH 1313
Query: 97 GTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNR-----IRLQVSKSPLWPKENLDPVV 151
G +++ + +E G+Y C N+ G A+ N I +SK + + V
Sbjct: 1314 GLQILNAQ-----KEDAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLAEVGVKEVK 1368
Query: 152 VQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDY 211
+ + LTL+C +P P I W +P+T R+ G L LQ T
Sbjct: 1369 TKVNSTLTLECESW-AVPPPTIRWYKDG-QPVTPSSRLQVLGEGRL------LQIQPTQV 1420
Query: 212 SCNARFHFTHT------------IQQKNPFTLKVLTTRGVAERTPSFMYPQGTASS-QMV 258
S + R+ T + Q P KV E +G + + +
Sbjct: 1421 SDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREI 1480
Query: 259 LRGMDLLLECIASGVPTPDIAWYKKGGDLPS-DKAKFENFNKALRITNVSEEDSGEYFCL 317
+ L C + +P PD+ WY++ L + D+ + L+I V E++G Y C
Sbjct: 1481 VENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCK 1540
Query: 318 ASNKMGSIRHTISVRVKAAPYWLDEPKNLI----LAPGEDGRLVCRANGNPKPTVQWMVN 373
ASN++G + V P L + + L+ + L C A GNP PT+ W+ N
Sbjct: 1541 ASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQN 1600
Query: 374 GEPLQSAPPNPNREVAGDTIIFR--DTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPR 431
G P P+P +V D + + +++ A Y C N+ G F + VPPR
Sbjct: 1601 GLPFS---PSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSA-EKLFTLRVQVPPR 1656
Query: 432 MLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMI 491
+ + + IL + L C P P + W+K+ Q +L + + +L++
Sbjct: 1657 IAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGTHTLQLGRA 1716
Query: 492 RKEDQGIYTCVATNILGKAENQVRLEVKDP---TRIYRMPEDQV-ARRGTTVQLECRVKH 547
R D G+YTC A N G+ + V+L V P + R P+D V R G L C
Sbjct: 1717 RLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCET-- 1774
Query: 548 DPSLKLTVSWLKDDEPLYIGNRMK--KEDDSLTIFGVAERDQGSYTCVASTELDQDLAKA 605
D + TV+W KD +PL + R + + L I D+G Y+C S + +
Sbjct: 1775 DALPEPTVTWYKDGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTF 1834
Query: 606 YLTV 609
LTV
Sbjct: 1835 TLTV 1838
Score = 156 bits (394), Expect = 6e-38
Identities = 152/563 (26%), Positives = 234/563 (41%), Gaps = 70/563 (12%)
Query: 57 DNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYE--- 113
D ++ CE P P+ W ++ + P V +R R G R E E
Sbjct: 1766 DKAVLSCETDALPEPTVTWYKDGQ-------PLVLAQRTQA-----LRGGQRLEIQEAQV 1813
Query: 114 ---GEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPS 170
G Y C N G A+ L V P + + V G+PL L C+ G+P+
Sbjct: 1814 SDKGLYSCKVSNVAGEAVRT-FTLTVQVPPTFENPKTETVSQVAGSPLVLTCDVS-GVPA 1871
Query: 171 PVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFT 230
P + W+ M + G L S + T Y+C A + + F
Sbjct: 1872 PTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGT-YTCVAE---NTQAEARKDFV 1927
Query: 231 LKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSD 290
+ VL VA R S G A VL G ++ L+C A G P PD+AW K G L D
Sbjct: 1928 VAVL----VAPRIRS----SGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQD 1979
Query: 291 KAKFENF---NKALRITNVSEEDSGEYFCLASNKMG--SIRHTISVRV-KAAPYWLDEPK 344
F +L + + D+G Y C+A N G + HT++V V D
Sbjct: 1980 MGPHLRFYLDGGSLVLKGLRASDAGAYTCVAHNPAGEDARLHTVNVLVPPTIKQGADGSG 2039
Query: 345 NLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREV---AGDTIIFRDTQIS 401
L+ PGE +VC G+P V W+ +G PL P R + +G T+ Q++
Sbjct: 2040 TLVSRPGELVTMVCPVRGSPPIHVSWLKDGLPL----PLSQRTLLHGSGHTLRISKVQLA 2095
Query: 402 SRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSP---RNQLIRVILYNRTRLDCPFFGSP 458
++ C ++ G N F + VPP +L P +N ++ V+ + L C G P
Sbjct: 2096 DAGIFTCVAASPAGVADRN-FTLQVQVPP-VLEPVEFQNDVV-VVRGSLVELPCEARGVP 2152
Query: 459 IPTLRWFKNGQ---GSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVR 515
+P + W K+G+ +L+ G SL+++ + D G Y+CVA + G+A +
Sbjct: 2153 LPLVSWMKDGEPLLSQSLEQG-------PSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQ 2205
Query: 516 LEVKDPTRI--YRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKE 573
L V +P I P + G ++L C + P +T W KD + L + E
Sbjct: 2206 LTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNIT--WHKDGQAL-----TRLE 2258
Query: 574 DDSLTIFGVAERDQGSYTCVAST 596
++S + RD G YTC+A +
Sbjct: 2259 NNSRATRVLRVRDAGLYTCLAES 2281
Score = 151 bits (382), Expect = 2e-36
Identities = 149/571 (26%), Positives = 230/571 (40%), Gaps = 37/571 (6%)
Query: 40 PPTI---TKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRS 96
PP I T++ ++ V+ + ++C A GNP P+ W +N F+ PR+ +
Sbjct: 1559 PPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFS--PSPRLQVLEDG 1616
Query: 97 GTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGA 156
L + Y C A N+ G+A L+V P +L+ V +
Sbjct: 1617 QVLQVSTAEVADA----ASYMCVAENQAGSA-EKLFTLRVQVPPRIAGLDLEQVTAILNS 1671
Query: 157 PLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNAR 216
++L C+ P+P + W S ++ L L D Y+C A
Sbjct: 1672 SVSLPCDVHAH-PNPEVTWYKDSQALSLGEEVFLLPGTHTLQLGRARLSDSGM-YTCEA- 1728
Query: 217 FHFTHTIQQKNPFTLKVLTTRGVAERTPSFMY-PQGTASSQMVLRGMDLLLECIASGVPT 275
+ + L VL P+F P+G + +V G +L C +P
Sbjct: 1729 --LNAAGRDQKLVQLSVLVP-------PAFRQAPRGPQDAVLVRVGDKAVLSCETDALPE 1779
Query: 276 PDIAWYKKGGDLP-SDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVK 334
P + WYK G L + + + + L I D G Y C SN G T ++ V+
Sbjct: 1780 PTVTWYKDGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQ 1839
Query: 335 AAPYWLDEPKNLILA--PGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDT 392
P + + PK ++ G L C +G P PTV W+ + P++S+ + G
Sbjct: 1840 VPPTF-ENPKTETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPVESSAVHGVVSRGGRL 1898
Query: 393 IIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDC 452
+ R Q + Y C N + V+VL P S + V+ RLDC
Sbjct: 1899 QLSR-LQPAQAGTYTCVAENTQAEARKDFVVAVLVAPRIRSSGVAREHHVLEGQEVRLDC 1957
Query: 453 PFFGSPIPTLRWFKNGQGSNLDGGNY--HVYENGSLEIKMIRKEDQGIYTCVATNILGKA 510
G P P + W K+G D G + + GSL +K +R D G YTCVA N G+
Sbjct: 1958 EADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVAHNPAGED 2017
Query: 511 ENQVRLEVKDPTRIYRMPEDQ---VARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIG 567
+ V P I + + V+R G V + C V+ P + VSWLKD PL +
Sbjct: 2018 ARLHTVNVLVPPTIKQGADGSGTLVSRPGELVTMVCPVRGSPPIH--VSWLKDGLPLPLS 2075
Query: 568 NR--MKKEDDSLTIFGVAERDQGSYTCVAST 596
R + +L I V D G +TCVA++
Sbjct: 2076 QRTLLHGSGHTLRISKVQLADAGIFTCVAAS 2106
Score = 150 bits (380), Expect = 3e-36
Identities = 144/580 (24%), Positives = 228/580 (39%), Gaps = 37/580 (6%)
Query: 37 LTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRS 96
L P + A++H V + ++CEA G P P W ++ P +
Sbjct: 1931 LVAPRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDG 1990
Query: 97 GTLVIDFRSGGRPEEYEGEYQCFARNKFG-TALSNRIRLQVSKSPLWPKENLDPVVVQEG 155
G+LV+ G G Y C A N G A + + + V + + +V + G
Sbjct: 1991 GSLVLK----GLRASDAGAYTCVAHNPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRPG 2046
Query: 156 APLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNA 215
+T+ C P G P + W+ + + + G L S V L D ++C A
Sbjct: 2047 ELVTMVC-PVRGSPPIHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGI-FTCVA 2104
Query: 216 RFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPT 275
+ +N FTL+V + P + P + +V+RG + L C A GVP
Sbjct: 2105 A--SPAGVADRN-FTLQV--------QVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPL 2153
Query: 276 PDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKA 335
P ++W K G L S + +L++ V DSG Y C+A ++ G R + V
Sbjct: 2154 PLVSWMKDGEPLLSQSLE---QGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVME 2210
Query: 336 APYWLD--EPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTI 393
P+ D +P L L PG L+C A G P+P + W +G+ L N
Sbjct: 2211 PPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQALTRLENNSRAT------ 2264
Query: 394 IFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRN-QLIRVILYNRTRLDC 452
R ++ +Y C + G + +F + PP ++ PR + + + + L+C
Sbjct: 2265 --RVLRVRDAGLYTCLAESPAG-AIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLVLEC 2321
Query: 453 PFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAEN 512
P P + W ++G D L+++ + D G Y+C A N G
Sbjct: 2322 SVEAEPAPKITWHRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSV 2381
Query: 513 QVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKK 572
R+E+ I P T L C+ P+ VSW KD PL + +
Sbjct: 2382 AFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPA--PLVSWRKDRVPLDPRSPRFE 2439
Query: 573 --EDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTVL 610
+ SL I V +D G Y C+AS D L VL
Sbjct: 2440 ILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVL 2479
Score = 150 bits (379), Expect = 3e-36
Identities = 148/591 (25%), Positives = 237/591 (40%), Gaps = 52/591 (8%)
Query: 40 PPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTL 99
PP IT + V + + C A G P+P+ W ++ + A P + + L
Sbjct: 694 PPRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVL 753
Query: 100 VIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLD-PVVVQEGAPL 158
+ + R + G Y C A + G + + LQV P E L+ VV E L
Sbjct: 754 TL---ASARASD-SGRYSCVAVSAVGEDRQDVV-LQVHMPPSILGEELNVSVVANESVAL 808
Query: 159 TLQCNPPPGLPSPVIFWMSSS--MEP-----ITQDKRVSQGHNGDLYFSNVMLQDMQTDY 211
Q + +P PV+ W +EP ++ DK + Q D++ + Y
Sbjct: 809 ECQSH---AMPPPVLSWWKDGRPLEPRPGVHLSADKALLQVDRADVWDAG--------HY 857
Query: 212 SCNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIAS 271
+C A H+ + N L V ++P + + V G L C
Sbjct: 858 TCEALNQAGHSEKHYN---LNVWVAP---------VFPLRESHTLTVREGHPTRLSCECR 905
Query: 272 GVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEED---SGEYFCLASNKMGSIRHT 328
GVP P I+W K G LP + A ++ + R+ + + G Y C SN +G+
Sbjct: 906 GVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQD 965
Query: 329 ISVRVKAAPYWL---DEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPN 385
+ + V P + P + + L C A G P PTV W +G+P+ A
Sbjct: 966 LQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQPV-GAELGLQ 1024
Query: 386 REVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQL--IRVI 443
+ G ++ Q + Y C N G +SVL VPP ++ + L I
Sbjct: 1025 LQNQGQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVL-VPPELIGDLDPLTNITAA 1083
Query: 444 LYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVA 503
L++ L C G P P +RWF+ + + Y + L++ +++D G+Y+C+A
Sbjct: 1084 LHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLA 1143
Query: 504 TNILGKAENQVRLEVKDPTRIYRMPEDQVAR--RGTTVQLECRVKHDPSLKLTVSWLKDD 561
+N G+A +EV P I ++V + G T L C V P KLT W KD
Sbjct: 1144 SNEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLT--WFKDG 1201
Query: 562 EPLYIGNRMKKEDDS--LTIFGVAERDQGSYTCVASTELDQDLAKAYLTVL 610
PL G+ D L + G Y+C+A+ + + L+VL
Sbjct: 1202 RPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVL 1252
Score = 149 bits (376), Expect = 7e-36
Identities = 152/581 (26%), Positives = 225/581 (38%), Gaps = 38/581 (6%)
Query: 34 QNELTQPPTITKQSAKDHI-VDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSM 92
Q + +PP I + + P + + C+A+G P P+ W ++ + R+
Sbjct: 2205 QLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQALT-----RLEN 2259
Query: 93 RRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTA-LSNRIRLQVSKSPLWPKENLDPVV 151
R+ T V+ R G Y C A + G S R+R+Q + + P+ V
Sbjct: 2260 NSRA-TRVLRVRDAGL-------YTCLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVG 2311
Query: 152 VQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDY 211
+ G L L+C+ P+P I W + + +D G + DY
Sbjct: 2312 LAPGQ-LVLECSVEAE-PAPKITWHRDGIV-LQEDAHTQFPERGRFLQLQALSTADSGDY 2368
Query: 212 SCNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIAS 271
SC AR T F +++ T + P+ V LL C A
Sbjct: 2369 SCTARNAAGST---SVAFRVEIHTVPTIRSGPPAVN----------VSVNQTALLPCQAD 2415
Query: 272 GVPTPDIAWYKKGGDLPSDKAKFENFNK-ALRITNVSEEDSGEYFCLASNKMGSIRHTIS 330
GVP P ++W K L +FE + +LRI V +D+G Y CLASN GS R
Sbjct: 2416 GVPAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRD 2475
Query: 331 VRVKAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQ-SAPPNPNREVA 389
+RV P P NL L L C A+G+PKP V W +G+ L R +
Sbjct: 2476 LRVLEPPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLP 2535
Query: 390 GDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTR 449
+ ++ A ++C SNE G + + VPP + + V +
Sbjct: 2536 SNALLLTAPGPQDSAQFECVVSNEVGE-AHRLYQVTVHVPPTIADDQTD-FTVTMMAPVV 2593
Query: 450 LDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGK 509
L C G P PT+ W K G G Y V +G+LEI G YTC A N G
Sbjct: 2594 LTCHSTGIPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGV 2653
Query: 510 AENQVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIG-N 568
A V L V+ + +P A V L C P + T++W K+ + G +
Sbjct: 2654 AHKHVFLTVQASPVVKPLPSVVRAVAEEEVLLPCEASGIP--RPTITWQKEGLNVATGVS 2711
Query: 569 RMKKEDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTV 609
L I + D G+Y C+A + K L V
Sbjct: 2712 TQVLPGGQLRIAHASPEDAGNYLCIAKNSAGSAMGKTRLVV 2752
Score = 144 bits (364), Expect = 2e-34
Identities = 146/562 (25%), Positives = 225/562 (40%), Gaps = 45/562 (8%)
Query: 61 IECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFA 120
+ CE +G P P W ++ + + + G L+ G EG Y C
Sbjct: 900 LSCECRGVPFPKISWRKDGQPLP-GEGAGLQHVSAVGRLLY---LGQAQLAQEGTYTCEC 955
Query: 121 RNKFGTALSNRIRLQVSKSP--LWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSS 178
N G + S ++L+V P P+E V V + TL+CN G P P + W
Sbjct: 956 SNVVGNS-SQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNAT-GKPPPTVTWERD 1013
Query: 179 SMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRG 238
+P+ + + + G YSC A + ++K F L VL
Sbjct: 1014 G-QPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAE-NLAGRAERK--FELSVLVP-- 1067
Query: 239 VAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDL-PSDKAKFENF 297
P + ++ L L C A G+P P I W++ + P +
Sbjct: 1068 -----PELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAG 1122
Query: 298 NKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILA--PGEDGR 355
L++T E+DSG Y CLASN+ G R SV V P +E ++ G+
Sbjct: 1123 GWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAH 1182
Query: 356 LVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQ--ISSRAVYQCNTSNE 413
L+C G+P+P + W +G PL + ++ D ++ + Q +SS Y C +N
Sbjct: 1183 LMCNVTGHPQPKLTWFKDGRPLARGDAH---HISPDGVLLQVLQANLSSAGHYSCIAANA 1239
Query: 414 HGYLLANAFVSVLDVPPRMLSPRNQL---IRVILYNRTRLDCPFFGSPIPTLRWFKNGQG 470
G + +SVL P + + + V + N L C P P + W K+G
Sbjct: 1240 VGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGAP 1299
Query: 471 SNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPED 530
+ L+I +KED G YTCV TN LG+A +EV P I + +D
Sbjct: 1300 FEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSISK--DD 1357
Query: 531 QVARRG---------TTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMK--KEDDSLTI 579
+A G +T+ LEC P T+ W KD +P+ +R++ E L I
Sbjct: 1358 PLAEVGVKEVKTKVNSTLTLECESWAVP--PPTIRWYKDGQPVTPSSRLQVLGEGRLLQI 1415
Query: 580 FGVAERDQGSYTCVASTELDQD 601
D G Y CVA+ +D
Sbjct: 1416 QPTQVSDSGRYLCVATNVAGED 1437
Score = 140 bits (354), Expect = 3e-33
Identities = 156/628 (24%), Positives = 253/628 (40%), Gaps = 86/628 (13%)
Query: 33 IQNELTQPPTIT-KQSAKDHIVDPRDNIL-IECEAKGNPAPSFHWTRNSRFFNIAKDPRV 90
+Q E+ PP I + + +D + +EC A G P P+ W R+ + + + +
Sbjct: 966 LQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQ--PVGAELGL 1023
Query: 91 SMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKE---NL 147
++ + +L ++ + G Y C A N L+ R + S L P E +L
Sbjct: 1024 QLQNQGQSLHVERAQAA----HTGRYSCVAEN-----LAGRAERKFELSVLVPPELIGDL 1074
Query: 148 DPVVVQEGA---PLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVML 204
DP+ A PLTL C G+P P I W EP VS G + L ML
Sbjct: 1075 DPLTNITAALHSPLTLLCEAM-GIPPPAIRWFRGE-EP------VSPGEDTYLLAGGWML 1126
Query: 205 QDMQTD------YSCNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMV 258
+ QT YSC A + + F+++VL P + + V
Sbjct: 1127 KMTQTQEQDSGLYSCLAS---NEAGEARRNFSVEVLV--------PPSIENEDLEEVIKV 1175
Query: 259 LRGMDLLLECIASGVPTPDIAWYKKGGDLP-SDKAKFENFNKALRITNVSEEDSGEYFCL 317
L G L C +G P P + W+K G L D L++ + +G Y C+
Sbjct: 1176 LDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCI 1235
Query: 318 ASNKMGSIRHTISVRVKAAPYWL-----DEPKNLILAPGEDGRLVCRANGNPKPTVQWMV 372
A+N +G + V AP L + + + L+C A P P + WM
Sbjct: 1236 AANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMK 1295
Query: 373 NGEPLQSAPPNPNREVAGDT--IIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPP 430
+G P +++ N ++ T + + Q Y C +NE G + N V VL +PP
Sbjct: 1296 DGAPFEASR---NIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVL-IPP 1351
Query: 431 RMLS--PRNQL----IRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENG 484
+ P ++ ++ + + L+C + P PT+RW+K+GQ + E
Sbjct: 1352 SISKDDPLAEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGR 1411
Query: 485 SLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYR----------MPEDQVAR 534
L+I+ + D G Y CVATN+ G+ + + ++ P + + ++ AR
Sbjct: 1412 LLQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEAR 1471
Query: 535 RGTT----------VQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMK--KEDDSLTIFGV 582
G T L C P LT W ++D+PL G+ + + L I V
Sbjct: 1472 GGVTEYREIVENNPAYLYCDTNAIPPPDLT--WYREDQPLSAGDEVSVLQGGRVLQIPLV 1529
Query: 583 AERDQGSYTCVASTELDQDLAKAYLTVL 610
+ G Y+C AS E+ +D L VL
Sbjct: 1530 RAENAGRYSCKASNEVGEDWLHYELLVL 1557
Score = 137 bits (345), Expect = 3e-32
Identities = 156/620 (25%), Positives = 248/620 (40%), Gaps = 63/620 (10%)
Query: 24 AIEIPMDPSIQNELTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFN 83
++E+ + PSI+NE + H++ C G+P P W ++ R
Sbjct: 1155 SVEVLVPPSIENEDLEEVIKVLDGQTAHLM---------CNVTGHPQPKLTWFKDGRPLA 1205
Query: 84 IAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPL-- 141
+S G L+ ++ G Y C A N G + +L V +P
Sbjct: 1206 RGDAHHISP---DGVLLQVLQAN---LSSAGHYSCIAANAVGEK-TKHFQLSVLLAPTIL 1258
Query: 142 -WPKENLDP-VVVQEGAPLTLQCNPPPGLPSPVIFWMSSSME-PITQDKRVSQGHNGDLY 198
+++ D V V P++L C PSP I WM +++ ++ G +G L
Sbjct: 1259 GGAEDSADEEVTVTVNNPISLICEAL-AFPSPNITWMKDGAPFEASRNIQLLPGTHG-LQ 1316
Query: 199 FSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMV 258
N +D Y+C ++ + ++VL +++ P +++
Sbjct: 1317 ILNAQKEDAG-QYTCVVTNELGEAVKN---YHVEVLIPPSISKDDPLAEVGVKEVKTKV- 1371
Query: 259 LRGMDLLLECIASGVPTPDIAWYKKGGDL-PSDKAKFENFNKALRITNVSEEDSGEYFCL 317
L LEC + VP P I WYK G + PS + + + L+I DSG Y C+
Sbjct: 1372 --NSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCV 1429
Query: 318 ASNKMGSIRHTISVRVKAAPYWLD----EPKNLILAPGEDGR----------------LV 357
A+N G +V ++ P + IL+ E+ R L
Sbjct: 1430 ATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLY 1489
Query: 358 CRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYL 417
C N P P + W +PL SA + G + + + Y C SNE G
Sbjct: 1490 CDTNAIPPPDLTWYREDQPL-SAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVGED 1548
Query: 418 LANAFVSVLDVPPRMLSPRNQLIRVILYNRTR---LDCPFFGSPIPTLRWFKNGQGSNLD 474
+ + VL PP +L +L+ + N + L CP G+P+PT+ W +NG +
Sbjct: 1549 WLHYELLVL-TPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFS-P 1606
Query: 475 GGNYHVYENGS-LEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQV- 532
V E+G L++ D Y CVA N G AE L V+ P RI + +QV
Sbjct: 1607 SPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQVPPRIAGLDLEQVT 1666
Query: 533 ARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTI-FGVAE-RDQGSY 590
A ++V L C V P+ ++T W KD + L +G + + T+ G A D G Y
Sbjct: 1667 AILNSSVSLPCDVHAHPNPEVT--WYKDSQALSLGEEVFLLPGTHTLQLGRARLSDSGMY 1724
Query: 591 TCVASTELDQDLAKAYLTVL 610
TC A +D L+VL
Sbjct: 1725 TCEALNAAGRDQKLVQLSVL 1744
Score = 137 bits (344), Expect = 4e-32
Identities = 126/505 (24%), Positives = 206/505 (40%), Gaps = 31/505 (6%)
Query: 30 DPSIQNELTQPPTITKQSAKDHIVDPR-DNILIECEAKGNPAPSFHWTRNSRFFNIAKDP 88
+P + PP+I + K ++ ++ +EC+A G P P W ++++ +
Sbjct: 6 EPLLNTGSVVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGW 65
Query: 89 R-----VSMRRRSGTLVIDF-RSGGRPEEYEGE---YQCFARNKFGTALSNRIRLQVSKS 139
+ + G ++D +S P EG+ Y C A N+ GTA + L ++
Sbjct: 66 AGYGWDLGWGQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVLTPP 125
Query: 140 PLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYF 199
+ V+ GA + LQC G+P+P + W + + +G +
Sbjct: 126 SVLGAGAAQEVLGLAGADVELQCWTS-GVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLR 184
Query: 200 SNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVL 259
+ Y C A F+ QQ F L+V P ++ V+
Sbjct: 185 ITGSHVGDEGRYQCVA---FSPAGQQARDFQLRV--------HAPPTIWGSNETGEVAVM 233
Query: 260 RGMDLLLECIASGVPTPDIAWYKKGGDLP-SDKAKFENFNKALRITNVSEEDSGEYFCLA 318
+ L C A GVPTP+I W+K G LP S K + + L++ D+G Y C A
Sbjct: 234 EDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKA 293
Query: 319 SNKMGSIRHTISVRVKAAPYWLD---EPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGE 375
SN +G+ + V P P + G L C A G+P PT+ W G
Sbjct: 294 SNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEGL 353
Query: 376 PLQSAPPNPNR-EVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLS 434
P+ A N +R E G + +S +Y C S+ G + V V VPP++L
Sbjct: 354 PV--AESNESRLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEV-QVPPQLLV 410
Query: 435 PRNQ-LIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRK 493
+ I+ L C GSP+PT++W +NG+ + G + +L I +
Sbjct: 411 AEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVEL 470
Query: 494 EDQGIYTCVATNILGKAENQVRLEV 518
+ G++ C ATN G A +V + V
Sbjct: 471 DHSGLFACQATNEAGTAGAEVEVSV 495
Score = 133 bits (334), Expect = 6e-31
Identities = 153/607 (25%), Positives = 231/607 (38%), Gaps = 88/607 (14%)
Query: 25 IEIPMDPSIQNELTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNI 84
+++P + L Q TI Q + + C+A G+P P+ W +N R
Sbjct: 402 VQVPPQLLVAEGLGQVTTIVGQPLE-----------LPCQASGSPVPTIQWLQNGR--PA 448
Query: 85 AKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPK 144
+ V + + TL ID ++ G + C A N+ GTA + ++VS W
Sbjct: 449 EELAGVQVASQGTTLHIDHVE----LDHSGLFACQATNEAGTAGAE---VEVSVHGEWAP 501
Query: 145 ENLDPVVVQ------EGAPLTLQCNPP--------------PGLPSPVIFWMSSSMEPIT 184
L+ + Q + C+PP G SP W + P
Sbjct: 502 GVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIP-- 559
Query: 185 QDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRGVAERTP 244
V+ L V L+D + Y+C A + K LKVL +
Sbjct: 560 ----VAYSLPPPLQIEKVDLRD-EGIYTCAAT---NLAGESKREVALKVLVPPNI----- 606
Query: 245 SFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFN-KALRI 303
+ ++ VL + LEC+ASGVP PD++W+K + S + + + LRI
Sbjct: 607 -----EPGPVNKAVLENASVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVLRI 661
Query: 304 TNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDG--------R 355
D+G Y C+ASN GS +RV P + L P G R
Sbjct: 662 EQAQLSDAGSYRCVASNVAGSTELRYGLRVNV-------PPRITLPPSLPGPVLVNTPVR 714
Query: 356 LVCRANGNPKPTVQWMVNGEPLQSAPPNPNREV--AGDTIIFRDTQISSRAVYQCNTSNE 413
L C A G P PT+ W+ +G P+ A P +V G + + S Y C +
Sbjct: 715 LTCNATGAPSPTLMWLKDGNPVSPA-GTPGLQVFPGGRVLTLASARASDSGRYSCVAVSA 773
Query: 414 HGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNL 473
G + + V +PP +L + V+ L+C P P L W+K+G+
Sbjct: 774 VGEDRQDVVLQV-HMPPSILGEELN-VSVVANESVALECQSHAMPPPVLSWWKDGRPLEP 831
Query: 474 DGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEV-KDPTRIYRMPEDQV 532
G + + L++ D G YTC A N G +E L V P R
Sbjct: 832 RPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGHSEKHYNLNVWVAPVFPLRESHTLT 891
Query: 533 ARRGTTVQLECRVKHDPSLKLTVSWLKDDEPL---YIGNRMKKEDDSLTIFGVAE-RDQG 588
R G +L C + P K +SW KD +PL G + L G A+ +G
Sbjct: 892 VREGHPTRLSCECRGVPFPK--ISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEG 949
Query: 589 SYTCVAS 595
+YTC S
Sbjct: 950 TYTCECS 956
Score = 122 bits (306), Expect = 1e-27
Identities = 103/378 (27%), Positives = 159/378 (42%), Gaps = 29/378 (7%)
Query: 244 PSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKK-------------GGDLPSD 290
P + G ++ + G L LEC A+G P P+I W K G DL
Sbjct: 16 PPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWG 75
Query: 291 KA---KFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDE--PKN 345
+ + + ++L + E DSG Y C A N+ G+ + + V P L +
Sbjct: 76 QVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGAGAAQE 135
Query: 346 LILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAV 405
++ G D L C +G P P V+W + +P+ P+ + G + + +
Sbjct: 136 VLGLAGADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGR 195
Query: 406 YQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWF 465
YQC + G + + V P S + V+ + +L C G P P + WF
Sbjct: 196 YQCVAFSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWF 255
Query: 466 KNGQGSNLDGGNYHVYENGSLEIKMIRKE--DQGIYTCVATNILGKAENQVRLEVKDPTR 523
K+G + L VY G ++++ R + D G+YTC A+N +G AE RL+V P
Sbjct: 256 KDG--ALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPT 313
Query: 524 IY---RMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDS--LT 578
I P A G V LEC + PS T+SW + P+ N + E D L
Sbjct: 314 IEGAGGRPYVVKAVAGRPVALECVARGHPS--PTLSWHHEGLPVAESNESRLETDGSVLR 371
Query: 579 IFGVAERDQGSYTCVAST 596
+ E G Y+CVAS+
Sbjct: 372 LESPGEASSGLYSCVASS 389
Score = 119 bits (298), Expect = 8e-27
Identities = 102/396 (25%), Positives = 173/396 (43%), Gaps = 32/396 (8%)
Query: 37 LTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRS 96
+ Q P + + D + + C+A+G+P P+ W ++ + + A+ + S
Sbjct: 2751 VVQVPPVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDGQPVSGAEGKFTI--QPS 2808
Query: 97 GTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGA 156
G L++ G + G Y C A N G A R+ L + P++ D + + G
Sbjct: 2809 GELLVKNLEG----QDAGTYTCTAENAVGRA-RRRVHLTILVLPVFTTLPGDRSL-RLGD 2862
Query: 157 PLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNA- 215
L L+C G P+P I W + P+T+ VS+ G + ++ Y C A
Sbjct: 2863 RLWLRC-AARGSPTPRIGWTVND-RPVTEG--VSEQDGGSTLQRAAVSREDSGTYVCWAE 2918
Query: 216 -RFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLR-GMDLLLECIASGV 273
R T + + VL QG A S +V G + L+C+ G
Sbjct: 2919 NRVGRTQAVSFVHVKEAPVL---------------QGEAFSYLVEPVGGSIQLDCVVRGD 2963
Query: 274 PTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRV 333
P PDI W K G L + + N +L I +D+G Y CLA N+MG + + + +
Sbjct: 2964 PVPDIHWIKDGLPLRGSHLRHQLQNGSLTIRRTERDDAGRYQCLAENEMGVAKKVVILVL 3023
Query: 334 KAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTI 393
++AP + EP+++ + G+D L C+A G P PT++W+ G+PL+++ R + ++
Sbjct: 3024 QSAPVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRAS--RRLRTLPDGSL 3081
Query: 394 IFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVP 429
+ + Y C N G A AF+ V P
Sbjct: 3082 WLENVETGDAGTYDCVAHNLLGSATARAFLVVRGEP 3117
Score = 112 bits (280), Expect = 1e-24
Identities = 126/483 (26%), Positives = 198/483 (40%), Gaps = 44/483 (9%)
Query: 155 GAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNV----MLQDMQTD 210
G LTL+C+ G P P I W+ + + G+ DL + V +L + Q+
Sbjct: 33 GQSLTLECDAN-GFPVPEIVWLKDAQ--LVGVPLGWAGYGWDLGWGQVGGHRLLDEGQS- 88
Query: 211 YSCNARFHFTHTIQQKNP--FTLKVLTTRGVAER-------TPSFMYPQGTASSQMVLRG 261
HF IQ+ + ++ + G A+R TP + G A + L G
Sbjct: 89 ------LHFPR-IQEGDSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGAGAAQEVLGLAG 141
Query: 262 MDLLLECIASGVPTPDIAWYK-KGGDLPSDK-AKFENFNKALRITNVSEEDSGEYFCLAS 319
D+ L+C SGVPTP + W K + LP + + + LRIT D G Y C+A
Sbjct: 142 ADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAF 201
Query: 320 NKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDG--RLVCRANGNPKPTVQWMVNGEPL 377
+ G +RV A P + +A ED +L+C A G P P + W +G L
Sbjct: 202 SPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALL 261
Query: 378 QSAPPNPNREV---AGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRM-- 432
P + V G + Q S VY C SN G + V VPP +
Sbjct: 262 ----PTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVY-VPPTIEG 316
Query: 433 LSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIR 492
R +++ + L+C G P PTL W G + + L ++
Sbjct: 317 AGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNESRLETDGSVLRLESPG 376
Query: 493 KEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPE-DQVAR-RGTTVQLECRVKHDPS 550
+ G+Y+CVA++ G+A Q +EV+ P ++ QV G ++L C+ P
Sbjct: 377 EASSGLYSCVASSPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSP- 435
Query: 551 LKLTVSWLKDDEPL--YIGNRMKKEDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLT 608
T+ WL++ P G ++ + +L I V G + C A+ E A+ ++
Sbjct: 436 -VPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEVEVS 494
Query: 609 VLG 611
V G
Sbjct: 495 VHG 497
>gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3874
Score = 181 bits (460), Expect = 1e-45
Identities = 165/587 (28%), Positives = 245/587 (41%), Gaps = 47/587 (8%)
Query: 40 PPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTR-NSRFFNIAKDPRVSMRRRSGT 98
PPTI D V +++ C + G PAP+ W++ ++ RVS SG
Sbjct: 2665 PPTIADDQT-DFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLGARGSGYRVSP---SGA 2720
Query: 99 LVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLW-PKENLDPVVVQEGAP 157
L I G + G Y C ARN G A + L V SP+ P ++ V +E
Sbjct: 2721 LEI----GQALPIHAGRYTCSARNSAGVA-HKHVFLTVQASPVVKPLPSVVRAVAEEEVL 2775
Query: 158 LTLQCNPPPGLPSPVIFWMSSSMEPITQ-DKRVSQGHNGDLYFSNVMLQDMQTDYSCNAR 216
L + + G+P P I W + T +V G G L ++ +D +Y C A
Sbjct: 2776 LPCEAS---GIPRPTITWQKEGLNVATGVSTQVLPG--GQLRIAHASPEDAG-NYLCIA- 2828
Query: 217 FHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTP 276
KN + TR V + P + G L C A G P P
Sbjct: 2829 ---------KNSAGSAMGKTRLVVQVPPVI---ENGLPDLSTTEGSHAFLPCKARGSPEP 2876
Query: 277 DIAWYKKGGDLPSDKAKFE-NFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKA 335
+I W K G + + KF + L + N+ +D+G Y C A N +G R + + +
Sbjct: 2877 NITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRARRRVHLTILV 2936
Query: 336 APYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIF 395
P + P + L G+ L C A G+P P + W VN P+ + + G T+
Sbjct: 2937 LPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEGV---SEQDGGSTLQR 2993
Query: 396 RDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFF 455
Y C N G A +FV V + P + L+ + +LDC
Sbjct: 2994 AAVSREDSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPV-GGSIQLDCVVR 3052
Query: 456 GSPIPTLRWFKNG---QGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAEN 512
G P+P + W K+G +GS+L H +NGSL I ++D G Y C+A N +G A+
Sbjct: 3053 GDPVPDIHWIKDGLPLRGSHLR----HQLQNGSLTIHRTERDDAGRYQCLAENEMGVAKK 3108
Query: 513 QVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKK 572
V L ++ P+D R G V L C+ +P+ T+ WL+ +PL R++
Sbjct: 3109 VVILVLQSAPVFQVEPQDMTVRSGDDVALRCQATGEPT--PTIEWLQAGQPLRASRRLRT 3166
Query: 573 -EDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTVLGNCPCSPW 618
D SL + V D G+Y CVA L A+A+L V G P W
Sbjct: 3167 LPDGSLWLENVETGDAGTYDCVAHNLLGSATARAFLVVRGE-PQGSW 3212
Score = 156 bits (395), Expect = 5e-38
Identities = 153/604 (25%), Positives = 252/604 (41%), Gaps = 55/604 (9%)
Query: 41 PTI---TKQSAKDHIVDPRDN-ILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRS 96
PTI + SA + + +N I + CEA P+P+ W ++ F +++ ++ +
Sbjct: 1346 PTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGAPFEASRNIQL-LPGTH 1404
Query: 97 GTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNR-----IRLQVSKSPLWPKENLDPVV 151
G +++ + +E G+Y C N+ G A+ N I +SK + + V
Sbjct: 1405 GLQILNAQ-----KEDAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLGEVGVKEVK 1459
Query: 152 VQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDY 211
+ + LTL+C +P P I W +P+T R+ G L LQ T
Sbjct: 1460 TKVNSTLTLECESW-AVPPPTIRWYKDG-QPVTPSSRLQVLGEGRL------LQIQPTQV 1511
Query: 212 SCNARFHFTHT------------IQQKNPFTLKVLTTRGVAERTPSFMYPQGTASS-QMV 258
S + R+ T + Q P KV E +G + + +
Sbjct: 1512 SDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREI 1571
Query: 259 LRGMDLLLECIASGVPTPDIAWYKKGGDLPS-DKAKFENFNKALRITNVSEEDSGEYFCL 317
+ L C + +P PD+ WY++ L + D+ + L+I V E++G Y C
Sbjct: 1572 VENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCK 1631
Query: 318 ASNKMGSIRHTISVRVKAAPYWLDEPKNLI----LAPGEDGRLVCRANGNPKPTVQWMVN 373
ASN++G + V P L + + L+ + L C A GNP PT+ W+ N
Sbjct: 1632 ASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQN 1691
Query: 374 GEPLQSAPPNPNREVAGDTIIFR--DTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPR 431
G P P+P +V D + + +++ A Y C N+ G F + VPPR
Sbjct: 1692 GLPFS---PSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSA-EKLFTLRVQVPPR 1747
Query: 432 MLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMI 491
+ + + IL + L C P P + W+K+ Q +L + + +L++
Sbjct: 1748 IAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGTHTLQLGRA 1807
Query: 492 RKEDQGIYTCVATNILGKAENQVRLEVKDP---TRIYRMPEDQV-ARRGTTVQLECRVKH 547
R D G+YTC A N G+ + V+L V P + R P+D V R G L C
Sbjct: 1808 RLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCET-- 1865
Query: 548 DPSLKLTVSWLKDDEPLYIGNRMK--KEDDSLTIFGVAERDQGSYTCVASTELDQDLAKA 605
D + TV+W KD +PL + R + + L I D+G Y+C S + +
Sbjct: 1866 DALPEPTVTWYKDGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTF 1925
Query: 606 YLTV 609
LTV
Sbjct: 1926 TLTV 1929
Score = 156 bits (394), Expect = 6e-38
Identities = 152/563 (26%), Positives = 234/563 (41%), Gaps = 70/563 (12%)
Query: 57 DNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYE--- 113
D ++ CE P P+ W ++ + P V +R R G R E E
Sbjct: 1857 DKAVLSCETDALPEPTVTWYKDGQ-------PLVLAQRTQA-----LRGGQRLEIQEAQV 1904
Query: 114 ---GEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPS 170
G Y C N G A+ L V P + + V G+PL L C+ G+P+
Sbjct: 1905 SDKGLYSCKVSNVAGEAVRT-FTLTVQVPPTFENPKTETVSQVAGSPLVLTCDVS-GVPA 1962
Query: 171 PVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFT 230
P + W+ M + G L S + T Y+C A + + F
Sbjct: 1963 PTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGT-YTCVAE---NTQAEARKDFV 2018
Query: 231 LKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSD 290
+ VL VA R S G A VL G ++ L+C A G P PD+AW K G L D
Sbjct: 2019 VAVL----VAPRIRS----SGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQD 2070
Query: 291 KAKFENF---NKALRITNVSEEDSGEYFCLASNKMG--SIRHTISVRV-KAAPYWLDEPK 344
F +L + + D+G Y C+A N G + HT++V V D
Sbjct: 2071 MGPHLRFYLDGGSLVLKGLRASDAGAYTCVAHNPAGEDARLHTVNVLVPPTIKQGADGSG 2130
Query: 345 NLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREV---AGDTIIFRDTQIS 401
L+ PGE +VC G+P V W+ +G PL P R + +G T+ Q++
Sbjct: 2131 TLVSRPGELVTMVCPVRGSPPIHVSWLKDGLPL----PLSQRTLLHGSGHTLRISKVQLA 2186
Query: 402 SRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSP---RNQLIRVILYNRTRLDCPFFGSP 458
++ C ++ G N F + VPP +L P +N ++ V+ + L C G P
Sbjct: 2187 DAGIFTCVAASPAGVADRN-FTLQVQVPP-VLEPVEFQNDVV-VVRGSLVELPCEARGVP 2243
Query: 459 IPTLRWFKNGQ---GSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVR 515
+P + W K+G+ +L+ G SL+++ + D G Y+CVA + G+A +
Sbjct: 2244 LPLVSWMKDGEPLLSQSLEQG-------PSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQ 2296
Query: 516 LEVKDPTRI--YRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKE 573
L V +P I P + G ++L C + P +T W KD + L + E
Sbjct: 2297 LTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNIT--WHKDGQAL-----TRLE 2349
Query: 574 DDSLTIFGVAERDQGSYTCVAST 596
++S + RD G YTC+A +
Sbjct: 2350 NNSRATRVLRVRDAGLYTCLAES 2372
Score = 151 bits (382), Expect = 2e-36
Identities = 149/571 (26%), Positives = 230/571 (40%), Gaps = 37/571 (6%)
Query: 40 PPTI---TKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRS 96
PP I T++ ++ V+ + ++C A GNP P+ W +N F+ PR+ +
Sbjct: 1650 PPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFS--PSPRLQVLEDG 1707
Query: 97 GTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGA 156
L + Y C A N+ G+A L+V P +L+ V +
Sbjct: 1708 QVLQVSTAEVADA----ASYMCVAENQAGSA-EKLFTLRVQVPPRIAGLDLEQVTAILNS 1762
Query: 157 PLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNAR 216
++L C+ P+P + W S ++ L L D Y+C A
Sbjct: 1763 SVSLPCDVHAH-PNPEVTWYKDSQALSLGEEVFLLPGTHTLQLGRARLSDSGM-YTCEA- 1819
Query: 217 FHFTHTIQQKNPFTLKVLTTRGVAERTPSFMY-PQGTASSQMVLRGMDLLLECIASGVPT 275
+ + L VL P+F P+G + +V G +L C +P
Sbjct: 1820 --LNAAGRDQKLVQLSVLVP-------PAFRQAPRGPQDAVLVRVGDKAVLSCETDALPE 1870
Query: 276 PDIAWYKKGGDLP-SDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVK 334
P + WYK G L + + + + L I D G Y C SN G T ++ V+
Sbjct: 1871 PTVTWYKDGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQ 1930
Query: 335 AAPYWLDEPKNLILA--PGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDT 392
P + + PK ++ G L C +G P PTV W+ + P++S+ + G
Sbjct: 1931 VPPTF-ENPKTETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPVESSAVHGVVSRGGRL 1989
Query: 393 IIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDC 452
+ R Q + Y C N + V+VL P S + V+ RLDC
Sbjct: 1990 QLSR-LQPAQAGTYTCVAENTQAEARKDFVVAVLVAPRIRSSGVAREHHVLEGQEVRLDC 2048
Query: 453 PFFGSPIPTLRWFKNGQGSNLDGGNY--HVYENGSLEIKMIRKEDQGIYTCVATNILGKA 510
G P P + W K+G D G + + GSL +K +R D G YTCVA N G+
Sbjct: 2049 EADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVAHNPAGED 2108
Query: 511 ENQVRLEVKDPTRIYRMPEDQ---VARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIG 567
+ V P I + + V+R G V + C V+ P + VSWLKD PL +
Sbjct: 2109 ARLHTVNVLVPPTIKQGADGSGTLVSRPGELVTMVCPVRGSPPIH--VSWLKDGLPLPLS 2166
Query: 568 NR--MKKEDDSLTIFGVAERDQGSYTCVAST 596
R + +L I V D G +TCVA++
Sbjct: 2167 QRTLLHGSGHTLRISKVQLADAGIFTCVAAS 2197
Score = 150 bits (380), Expect = 3e-36
Identities = 144/580 (24%), Positives = 228/580 (39%), Gaps = 37/580 (6%)
Query: 37 LTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRS 96
L P + A++H V + ++CEA G P P W ++ P +
Sbjct: 2022 LVAPRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDG 2081
Query: 97 GTLVIDFRSGGRPEEYEGEYQCFARNKFG-TALSNRIRLQVSKSPLWPKENLDPVVVQEG 155
G+LV+ G G Y C A N G A + + + V + + +V + G
Sbjct: 2082 GSLVLK----GLRASDAGAYTCVAHNPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRPG 2137
Query: 156 APLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNA 215
+T+ C P G P + W+ + + + G L S V L D ++C A
Sbjct: 2138 ELVTMVC-PVRGSPPIHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGI-FTCVA 2195
Query: 216 RFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPT 275
+ +N FTL+V + P + P + +V+RG + L C A GVP
Sbjct: 2196 A--SPAGVADRN-FTLQV--------QVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPL 2244
Query: 276 PDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKA 335
P ++W K G L S + +L++ V DSG Y C+A ++ G R + V
Sbjct: 2245 PLVSWMKDGEPLLSQSLE---QGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVME 2301
Query: 336 APYWLD--EPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTI 393
P+ D +P L L PG L+C A G P+P + W +G+ L N
Sbjct: 2302 PPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQALTRLENNSRAT------ 2355
Query: 394 IFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRN-QLIRVILYNRTRLDC 452
R ++ +Y C + G + +F + PP ++ PR + + + + L+C
Sbjct: 2356 --RVLRVRDAGLYTCLAESPAG-AIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLVLEC 2412
Query: 453 PFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAEN 512
P P + W ++G D L+++ + D G Y+C A N G
Sbjct: 2413 SVEAEPAPKITWHRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSV 2472
Query: 513 QVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKK 572
R+E+ I P T L C+ P+ VSW KD PL + +
Sbjct: 2473 AFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPA--PLVSWRKDRVPLDPRSPRFE 2530
Query: 573 --EDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTVL 610
+ SL I V +D G Y C+AS D L VL
Sbjct: 2531 ILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVL 2570
Score = 149 bits (376), Expect = 7e-36
Identities = 146/591 (24%), Positives = 236/591 (39%), Gaps = 52/591 (8%)
Query: 40 PPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTL 99
PP IT + V + + C A G P+P+ W ++ + A P + + L
Sbjct: 785 PPRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVL 844
Query: 100 VIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLD-PVVVQEGAPL 158
+ + R + G Y C A + G + + LQV P E L+ VV E L
Sbjct: 845 TL---ASARASD-SGRYSCVAVSAVGEDRQDVV-LQVHMPPSILGEELNVSVVANESVAL 899
Query: 159 TLQCNPPPGLPSPVIFWMSSS--MEP-----ITQDKRVSQGHNGDLYFSNVMLQDMQTDY 211
Q + +P PV+ W +EP ++ DK + Q D++ + Y
Sbjct: 900 ECQSH---AMPPPVLSWWKDGRPLEPRPGVHLSADKALLQVDRADVWDAG--------HY 948
Query: 212 SCNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIAS 271
+C A + + + L V ++P + + V G L C
Sbjct: 949 TCEA---LNQAGRSEKHYNLNVWVAP---------VFPLRESHTLTVREGHPTSLSCECR 996
Query: 272 GVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEED---SGEYFCLASNKMGSIRHT 328
GVP P I+W K G LP + A ++ + R+ + + G Y C SN +G+
Sbjct: 997 GVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQD 1056
Query: 329 ISVRVKAAPYWL---DEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPN 385
+ + V P + P + + L C A G P PTV W +G+P+ A
Sbjct: 1057 LQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQPV-GAELGLQ 1115
Query: 386 REVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQL--IRVI 443
+ G ++ Q + Y C N G +SVL VPP ++ + L I
Sbjct: 1116 LQNQGQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVL-VPPELIGDLDPLTNITAA 1174
Query: 444 LYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVA 503
L++ L C G P P +RWF+ + + Y + L++ +++D G+Y+C+A
Sbjct: 1175 LHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLA 1234
Query: 504 TNILGKAENQVRLEVKDPTRIYRMPEDQVAR--RGTTVQLECRVKHDPSLKLTVSWLKDD 561
+N G+A +EV P I ++V + G T L C V P KLT W KD
Sbjct: 1235 SNEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLT--WFKDG 1292
Query: 562 EPLYIGNRMKKEDDS--LTIFGVAERDQGSYTCVASTELDQDLAKAYLTVL 610
PL G+ D L + G Y+C+A+ + + L+VL
Sbjct: 1293 RPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVL 1343
Score = 149 bits (376), Expect = 7e-36
Identities = 152/581 (26%), Positives = 225/581 (38%), Gaps = 38/581 (6%)
Query: 34 QNELTQPPTITKQSAKDHI-VDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSM 92
Q + +PP I + + P + + C+A+G P P+ W ++ + R+
Sbjct: 2296 QLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQALT-----RLEN 2350
Query: 93 RRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTA-LSNRIRLQVSKSPLWPKENLDPVV 151
R+ T V+ R G Y C A + G S R+R+Q + + P+ V
Sbjct: 2351 NSRA-TRVLRVRDAGL-------YTCLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVG 2402
Query: 152 VQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDY 211
+ G L L+C+ P+P I W + + +D G + DY
Sbjct: 2403 LAPGQ-LVLECSVEAE-PAPKITWHRDGIV-LQEDAHTQFPERGRFLQLQALSTADSGDY 2459
Query: 212 SCNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIAS 271
SC AR T F +++ T + P+ V LL C A
Sbjct: 2460 SCTARNAAGST---SVAFRVEIHTVPTIRSGPPAVN----------VSVNQTALLPCQAD 2506
Query: 272 GVPTPDIAWYKKGGDLPSDKAKFENFNK-ALRITNVSEEDSGEYFCLASNKMGSIRHTIS 330
GVP P ++W K L +FE + +LRI V +D+G Y CLASN GS R
Sbjct: 2507 GVPAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRD 2566
Query: 331 VRVKAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQ-SAPPNPNREVA 389
+RV P P NL L L C A+G+PKP V W +G+ L R +
Sbjct: 2567 LRVLEPPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLP 2626
Query: 390 GDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTR 449
+ ++ A ++C SNE G + + VPP + + V +
Sbjct: 2627 SNALLLTAPGPQDSAQFECVVSNEVGE-AHRLYQVTVHVPPTIADDQTD-FTVTMMAPVV 2684
Query: 450 LDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGK 509
L C G P PT+ W K G G Y V +G+LEI G YTC A N G
Sbjct: 2685 LTCHSTGIPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGV 2744
Query: 510 AENQVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIG-N 568
A V L V+ + +P A V L C P + T++W K+ + G +
Sbjct: 2745 AHKHVFLTVQASPVVKPLPSVVRAVAEEEVLLPCEASGIP--RPTITWQKEGLNVATGVS 2802
Query: 569 RMKKEDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTV 609
L I + D G+Y C+A + K L V
Sbjct: 2803 TQVLPGGQLRIAHASPEDAGNYLCIAKNSAGSAMGKTRLVV 2843
Score = 143 bits (360), Expect = 5e-34
Identities = 145/562 (25%), Positives = 224/562 (39%), Gaps = 45/562 (8%)
Query: 61 IECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFA 120
+ CE +G P P W ++ + + + G L+ G EG Y C
Sbjct: 991 LSCECRGVPFPKISWRKDGQPLP-GEGAGLQHVSAVGRLLY---LGQAQLAQEGTYTCEC 1046
Query: 121 RNKFGTALSNRIRLQVSKSP--LWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSS 178
N G + S ++L+V P P+E V V + TL+CN G P P + W
Sbjct: 1047 SNVVGNS-SQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNAT-GKPPPTVTWERD 1104
Query: 179 SMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRG 238
+P+ + + + G YSC A + ++K F L VL
Sbjct: 1105 G-QPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAE-NLAGRAERK--FELSVLVP-- 1158
Query: 239 VAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDL-PSDKAKFENF 297
P + ++ L L C A G+P P I W++ + P +
Sbjct: 1159 -----PELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAG 1213
Query: 298 NKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILA--PGEDGR 355
L++T E+DSG Y CLASN+ G R SV V P +E ++ G+
Sbjct: 1214 GWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAH 1273
Query: 356 LVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQ--ISSRAVYQCNTSNE 413
L+C G+P+P + W +G PL + ++ D ++ + Q +SS Y C +N
Sbjct: 1274 LMCNVTGHPQPKLTWFKDGRPLARGDAH---HISPDGVLLQVLQANLSSAGHYSCIAANA 1330
Query: 414 HGYLLANAFVSVLDVPPRMLSPRNQL---IRVILYNRTRLDCPFFGSPIPTLRWFKNGQG 470
G + +SVL P + + + V + N L C P P + W K+G
Sbjct: 1331 VGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGAP 1390
Query: 471 SNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPED 530
+ L+I +KED G YTCV TN LG+A +EV P I + +D
Sbjct: 1391 FEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSISK--DD 1448
Query: 531 QVARRG---------TTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMK--KEDDSLTI 579
+ G +T+ LEC P T+ W KD +P+ +R++ E L I
Sbjct: 1449 PLGEVGVKEVKTKVNSTLTLECESWAVP--PPTIRWYKDGQPVTPSSRLQVLGEGRLLQI 1506
Query: 580 FGVAERDQGSYTCVASTELDQD 601
D G Y CVA+ +D
Sbjct: 1507 QPTQVSDSGRYLCVATNVAGED 1528
Score = 141 bits (356), Expect = 2e-33
Identities = 156/628 (24%), Positives = 253/628 (40%), Gaps = 86/628 (13%)
Query: 33 IQNELTQPPTIT-KQSAKDHIVDPRDNIL-IECEAKGNPAPSFHWTRNSRFFNIAKDPRV 90
+Q E+ PP I + + +D + +EC A G P P+ W R+ + + + +
Sbjct: 1057 LQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQ--PVGAELGL 1114
Query: 91 SMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKE---NL 147
++ + +L ++ + G Y C A N L+ R + S L P E +L
Sbjct: 1115 QLQNQGQSLHVERAQAA----HTGRYSCVAEN-----LAGRAERKFELSVLVPPELIGDL 1165
Query: 148 DPVVVQEGA---PLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVML 204
DP+ A PLTL C G+P P I W EP VS G + L ML
Sbjct: 1166 DPLTNITAALHSPLTLLCEAM-GIPPPAIRWFRGE-EP------VSPGEDTYLLAGGWML 1217
Query: 205 QDMQTD------YSCNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMV 258
+ QT YSC A + + F+++VL P + + V
Sbjct: 1218 KMTQTQEQDSGLYSCLAS---NEAGEARRNFSVEVLV--------PPSIENEDLEEVIKV 1266
Query: 259 LRGMDLLLECIASGVPTPDIAWYKKGGDLP-SDKAKFENFNKALRITNVSEEDSGEYFCL 317
L G L C +G P P + W+K G L D L++ + +G Y C+
Sbjct: 1267 LDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCI 1326
Query: 318 ASNKMGSIRHTISVRVKAAPYWL-----DEPKNLILAPGEDGRLVCRANGNPKPTVQWMV 372
A+N +G + V AP L + + + L+C A P P + WM
Sbjct: 1327 AANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMK 1386
Query: 373 NGEPLQSAPPNPNREVAGDT--IIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPP 430
+G P +++ N ++ T + + Q Y C +NE G + N V VL +PP
Sbjct: 1387 DGAPFEASR---NIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVL-IPP 1442
Query: 431 RMLS--PRNQL----IRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENG 484
+ P ++ ++ + + L+C + P PT+RW+K+GQ + E
Sbjct: 1443 SISKDDPLGEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGR 1502
Query: 485 SLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYR----------MPEDQVAR 534
L+I+ + D G Y CVATN+ G+ + + ++ P + + ++ AR
Sbjct: 1503 LLQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEAR 1562
Query: 535 RGTT----------VQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMK--KEDDSLTIFGV 582
G T L C P LT W ++D+PL G+ + + L I V
Sbjct: 1563 GGVTEYREIVENNPAYLYCDTNAIPPPDLT--WYREDQPLSAGDEVSVLQGGRVLQIPLV 1620
Query: 583 AERDQGSYTCVASTELDQDLAKAYLTVL 610
+ G Y+C AS E+ +D L VL
Sbjct: 1621 RAENAGRYSCKASNEVGEDWLHYELLVL 1648
Score = 137 bits (344), Expect = 4e-32
Identities = 156/620 (25%), Positives = 248/620 (40%), Gaps = 63/620 (10%)
Query: 24 AIEIPMDPSIQNELTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFN 83
++E+ + PSI+NE + H++ C G+P P W ++ R
Sbjct: 1246 SVEVLVPPSIENEDLEEVIKVLDGQTAHLM---------CNVTGHPQPKLTWFKDGRPLA 1296
Query: 84 IAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPL-- 141
+S G L+ ++ G Y C A N G + +L V +P
Sbjct: 1297 RGDAHHISP---DGVLLQVLQAN---LSSAGHYSCIAANAVGEK-TKHFQLSVLLAPTIL 1349
Query: 142 -WPKENLDP-VVVQEGAPLTLQCNPPPGLPSPVIFWMSSSME-PITQDKRVSQGHNGDLY 198
+++ D V V P++L C PSP I WM +++ ++ G +G L
Sbjct: 1350 GGAEDSADEEVTVTVNNPISLICEAL-AFPSPNITWMKDGAPFEASRNIQLLPGTHG-LQ 1407
Query: 199 FSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMV 258
N +D Y+C ++ + ++VL +++ P +++
Sbjct: 1408 ILNAQKEDAG-QYTCVVTNELGEAVKN---YHVEVLIPPSISKDDPLGEVGVKEVKTKV- 1462
Query: 259 LRGMDLLLECIASGVPTPDIAWYKKGGDL-PSDKAKFENFNKALRITNVSEEDSGEYFCL 317
L LEC + VP P I WYK G + PS + + + L+I DSG Y C+
Sbjct: 1463 --NSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCV 1520
Query: 318 ASNKMGSIRHTISVRVKAAPYWLD----EPKNLILAPGEDGR----------------LV 357
A+N G +V ++ P + IL+ E+ R L
Sbjct: 1521 ATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLY 1580
Query: 358 CRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYL 417
C N P P + W +PL SA + G + + + Y C SNE G
Sbjct: 1581 CDTNAIPPPDLTWYREDQPL-SAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVGED 1639
Query: 418 LANAFVSVLDVPPRMLSPRNQLIRVILYNRTR---LDCPFFGSPIPTLRWFKNGQGSNLD 474
+ + VL PP +L +L+ + N + L CP G+P+PT+ W +NG +
Sbjct: 1640 WLHYELLVL-TPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFS-P 1697
Query: 475 GGNYHVYENGS-LEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQV- 532
V E+G L++ D Y CVA N G AE L V+ P RI + +QV
Sbjct: 1698 SPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQVPPRIAGLDLEQVT 1757
Query: 533 ARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTI-FGVAE-RDQGSY 590
A ++V L C V P+ ++T W KD + L +G + + T+ G A D G Y
Sbjct: 1758 AILNSSVSLPCDVHAHPNPEVT--WYKDSQALSLGEEVFLLPGTHTLQLGRARLSDSGMY 1815
Query: 591 TCVASTELDQDLAKAYLTVL 610
TC A +D L+VL
Sbjct: 1816 TCEALNAAGRDQKLVQLSVL 1835
Score = 134 bits (336), Expect = 3e-31
Identities = 153/607 (25%), Positives = 231/607 (38%), Gaps = 88/607 (14%)
Query: 25 IEIPMDPSIQNELTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNI 84
+++P + L Q TI Q + + C+A G+P P+ W +N R
Sbjct: 493 VQVPPQLLVAEGLGQVTTIVGQPLE-----------LPCQASGSPVPTIQWLQNGR--PA 539
Query: 85 AKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPK 144
+ V + + TL ID ++ G + C A N+ GTA + ++VS W
Sbjct: 540 EELAGVQVASQGTTLHIDHVE----LDHSGLFACQATNEAGTAGAE---VEVSVHGEWAP 592
Query: 145 ENLDPVVVQ------EGAPLTLQCNPP--------------PGLPSPVIFWMSSSMEPIT 184
L+ + Q + C+PP G SP W + P
Sbjct: 593 GVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIP-- 650
Query: 185 QDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRGVAERTP 244
V+ L V L+D + Y+C A + K LKVL +
Sbjct: 651 ----VAYSLPPPLQIEKVDLRD-EGIYTCAAT---NLAGESKREVALKVLVPPNI----- 697
Query: 245 SFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFN-KALRI 303
+ ++ VL + LEC+ASGVP PD++W+K + S + + + LRI
Sbjct: 698 -----EPGPVNKAVLENASVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVLRI 752
Query: 304 TNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDG--------R 355
D+G Y C+ASN GS +RV P + L P G R
Sbjct: 753 EQAQLSDAGSYRCVASNVAGSTELRYGLRVNV-------PPRITLPPSLPGPVLVNTPVR 805
Query: 356 LVCRANGNPKPTVQWMVNGEPLQSAPPNPNREV--AGDTIIFRDTQISSRAVYQCNTSNE 413
L C A G P PT+ W+ +G P+ A P +V G + + S Y C +
Sbjct: 806 LTCNATGAPSPTLMWLKDGNPVSPA-GTPGLQVFPGGRVLTLASARASDSGRYSCVAVSA 864
Query: 414 HGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNL 473
G + + V +PP +L + V+ L+C P P L W+K+G+
Sbjct: 865 VGEDRQDVVLQV-HMPPSILGEELN-VSVVANESVALECQSHAMPPPVLSWWKDGRPLEP 922
Query: 474 DGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEV-KDPTRIYRMPEDQV 532
G + + L++ D G YTC A N G++E L V P R
Sbjct: 923 RPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGRSEKHYNLNVWVAPVFPLRESHTLT 982
Query: 533 ARRGTTVQLECRVKHDPSLKLTVSWLKDDEPL---YIGNRMKKEDDSLTIFGVAE-RDQG 588
R G L C + P K +SW KD +PL G + L G A+ +G
Sbjct: 983 VREGHPTSLSCECRGVPFPK--ISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEG 1040
Query: 589 SYTCVAS 595
+YTC S
Sbjct: 1041 TYTCECS 1047
Score = 129 bits (324), Expect = 8e-30
Identities = 127/508 (25%), Positives = 200/508 (39%), Gaps = 44/508 (8%)
Query: 40 PPTITKQSAKDHIVDPR-DNILIECEAKGNPAPSFHWTRNSRFFNIAKDPR-----VSMR 93
PP+I + K ++ ++ +EC+A G P P W ++++ + +
Sbjct: 94 PPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWG 153
Query: 94 RRSGTLVIDF------------RSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPL 141
+ G ++D RSG R + G Q A G A + + SP
Sbjct: 154 QVGGHRLLDEGQSLHFPRIQPGRSGRRGAQAGGSAQTKAPWXAGLAGFEQFPTPHAFSPP 213
Query: 142 WPKENLDPVVVQE-----GAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGD 196
P L QE GA + LQC G+P+P + W + + +G
Sbjct: 214 APPSVLGAGAAQEVLGLAGADVELQCWTS-GVPTPQVEWTKDRQPVLPGGPHLQVQEDGQ 272
Query: 197 LYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQ 256
+ + Y C A F+ QQ F L+V P ++
Sbjct: 273 VLRITGSHVGDEGRYQCVA---FSPAGQQARDFQLRV--------HAPPTIWGSNETGEV 321
Query: 257 MVLRGMDLLLECIASGVPTPDIAWYKKGGDLP-SDKAKFENFNKALRITNVSEEDSGEYF 315
V+ + L C A GVPTP+I W+K G LP S K + + L++ D+G Y
Sbjct: 322 AVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYT 381
Query: 316 CLASNKMGSIRHTISVRVKAAPYWLD---EPKNLILAPGEDGRLVCRANGNPKPTVQWMV 372
C ASN +G+ + V P P + G L C A G+P PT+ W
Sbjct: 382 CKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHH 441
Query: 373 NGEPLQSAPPNPNR-EVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPR 431
G P+ A N +R E G + +S +Y C S+ G + V V VPP+
Sbjct: 442 EGLPV--AESNESRLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEV-QVPPQ 498
Query: 432 MLSPRNQ-LIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKM 490
+L + I+ L C GSP+PT++W +NG+ + G + +L I
Sbjct: 499 LLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDH 558
Query: 491 IRKEDQGIYTCVATNILGKAENQVRLEV 518
+ + G++ C ATN G A +V + V
Sbjct: 559 VELDHSGLFACQATNEAGTAGAEVEVSV 586
Score = 119 bits (299), Expect = 6e-27
Identities = 146/581 (25%), Positives = 230/581 (39%), Gaps = 48/581 (8%)
Query: 63 CEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARN 122
C G P P W + + P V++ G+L F + P + G+Y+C A N
Sbjct: 24 CGTHGTPKPQVTWRKGPSSEPLHGQPGVAVLEE-GSL---FLASVSPAD-SGDYECQATN 78
Query: 123 KFGTALSNRIRLQVSKSPLWPKENLDPVVV-QEGAPLTLQCNPPPGLPSPVIFWMSSSME 181
+ G+ S R +L V P ++ V G LTL+C+ G P P I W+ +
Sbjct: 79 EVGST-SRRAKLVVYVPPSIREDGRKANVSGMAGQSLTLECDAN-GFPVPEIVWLKDAQ- 135
Query: 182 PITQDKRVSQGHNGDLYFSNV----MLQD--------MQTDYSCNARFHFTHTIQQKNPF 229
+ G+ DL + V +L + +Q S + Q K P+
Sbjct: 136 -LVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQPGRSGRRGAQAGGSAQTKAPW 194
Query: 230 TLKVL------TTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYK- 282
+ T + P + G A + L G D+ L+C SGVPTP + W K
Sbjct: 195 XAGLAGFEQFPTPHAFSPPAPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTKD 254
Query: 283 KGGDLPSDK-AKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLD 341
+ LP + + + LRIT D G Y C+A + G +RV A P
Sbjct: 255 RQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPPTIWG 314
Query: 342 EPKNLILAPGEDG--RLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREV---AGDTIIFR 396
+ +A ED +L+C A G P P + W +G L P + V G +
Sbjct: 315 SNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALL----PTSTKVVYTRGGRQLQLG 370
Query: 397 DTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRM--LSPRNQLIRVILYNRTRLDCPF 454
Q S VY C SN G + V VPP + R +++ + L+C
Sbjct: 371 RAQSSDAGVYTCKASNAVGAAEKATRLDVY-VPPTIEGAGGRPYVVKAVAGRPVALECVA 429
Query: 455 FGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQV 514
G P PTL W G + + L ++ + G+Y+CVA++ G+A Q
Sbjct: 430 RGHPSPTLSWHHEGLPVAESNESRLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQY 489
Query: 515 RLEVKDPTRIYRMPE-DQVAR-RGTTVQLECRVKHDPSLKLTVSWLKDDEPL--YIGNRM 570
+EV+ P ++ QV G ++L C+ P T+ WL++ P G ++
Sbjct: 490 SVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSP--VPTIQWLQNGRPAEELAGVQV 547
Query: 571 KKEDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTVLG 611
+ +L I V G + C A+ E A+ ++V G
Sbjct: 548 ASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHG 588
Score = 119 bits (297), Expect = 1e-26
Identities = 102/396 (25%), Positives = 173/396 (43%), Gaps = 32/396 (8%)
Query: 37 LTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRS 96
+ Q P + + D + + C+A+G+P P+ W ++ + + A+ + S
Sbjct: 2842 VVQVPPVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDGQPVSGAEGKFTI--QPS 2899
Query: 97 GTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGA 156
G L++ G + G Y C A N G A R+ L + P++ D + + G
Sbjct: 2900 GELLVKNLEG----QDAGTYTCTAENAVGRA-RRRVHLTILVLPVFTTLPGDRSL-RLGD 2953
Query: 157 PLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNA- 215
L L+C G P+P I W + P+T+ VS+ G + ++ Y C A
Sbjct: 2954 RLWLRC-AARGSPTPRIGWTVND-RPVTEG--VSEQDGGSTLQRAAVSREDSGTYVCWAE 3009
Query: 216 -RFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLR-GMDLLLECIASGV 273
R T + + VL QG A S +V G + L+C+ G
Sbjct: 3010 NRVGRTQAVSFVHVKEAPVL---------------QGEAFSYLVEPVGGSIQLDCVVRGD 3054
Query: 274 PTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRV 333
P PDI W K G L + + N +L I +D+G Y CLA N+MG + + + +
Sbjct: 3055 PVPDIHWIKDGLPLRGSHLRHQLQNGSLTIHRTERDDAGRYQCLAENEMGVAKKVVILVL 3114
Query: 334 KAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTI 393
++AP + EP+++ + G+D L C+A G P PT++W+ G+PL+++ R + ++
Sbjct: 3115 QSAPVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRAS--RRLRTLPDGSL 3172
Query: 394 IFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVP 429
+ + Y C N G A AF+ V P
Sbjct: 3173 WLENVETGDAGTYDCVAHNLLGSATARAFLVVRGEP 3208
Score = 116 bits (291), Expect = 5e-26
Identities = 151/596 (25%), Positives = 229/596 (38%), Gaps = 54/596 (9%)
Query: 40 PPTITKQSAKDHIVDPRDNIL-IECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGT 98
PPTI + + D+++ + CEA+G P P+ W ++ + +V R
Sbjct: 309 PPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGAL--LPTSTKVVYTRGGRQ 366
Query: 99 LVIDFRSGGRPEEYE-GEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQ--EG 155
L + GR + + G Y C A N G A RL V P P VV+ G
Sbjct: 367 LQL-----GRAQSSDAGVYTCKASNAVGAA-EKATRLDVYVPPTIEGAGGRPYVVKAVAG 420
Query: 156 APLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNA 215
P+ L+C G PSP + W + P+ + +G + + YSC A
Sbjct: 421 RPVALEC-VARGHPSPTLSWHHEGL-PVAESNESRLETDGSVLRLESPGEASSGLYSCVA 478
Query: 216 RFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPT 275
+P VL + P + +G ++ G L L C ASG P
Sbjct: 479 ----------SSPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIV-GQPLELPCQASGSPV 527
Query: 276 PDIAWYKKGGDLPSDK---AKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVR 332
P I W + G P+++ + + L I +V + SG + C A+N+ G+ + V
Sbjct: 528 PTIQWLQNG--RPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEVEVS 585
Query: 333 VKA--APYWLDEP--------KNLILAPGEDGRLVCRANG-NPKPTV--QWMVNGEPLQS 379
V AP L+ P ++ P V R G +PKP + W G
Sbjct: 586 VHGEWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGE 645
Query: 380 APPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQL 439
P + + +Y C +N G + VL VPP + +
Sbjct: 646 PTGIPVAYSLPPPLQIEKVDLRDEGIYTCAATNLAGESKREVALKVL-VPPNI--EPGPV 702
Query: 440 IRVILYNRT-RLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGI 498
+ +L N + L+C G P P + WFK Q + G + L I+ + D G
Sbjct: 703 NKAVLENASVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGS 762
Query: 499 YTCVATNILGKAENQVRLEVKDPTRIYRMPE-DQVARRGTTVQLECRVKHDPSLKLTVSW 557
Y CVA+N+ G E + L V P RI P T V+L C PS T+ W
Sbjct: 763 YRCVASNVAGSTELRYGLRVNVPPRITLPPSLPGPVLVNTPVRLTCNATGAPS--PTLMW 820
Query: 558 LKDDEPL----YIGNRMKKEDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTV 609
LKD P+ G ++ LT+ D G Y+CVA + + +D L V
Sbjct: 821 LKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQV 876
>gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 5065
Score = 181 bits (460), Expect = 1e-45
Identities = 165/587 (28%), Positives = 245/587 (41%), Gaps = 47/587 (8%)
Query: 40 PPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTR-NSRFFNIAKDPRVSMRRRSGT 98
PPTI D V +++ C + G PAP+ W++ ++ RVS SG
Sbjct: 3856 PPTIADDQT-DFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLGARGSGYRVSP---SGA 3911
Query: 99 LVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLW-PKENLDPVVVQEGAP 157
L I G + G Y C ARN G A + L V SP+ P ++ V +E
Sbjct: 3912 LEI----GQALPIHAGRYTCSARNSAGVA-HKHVFLTVQASPVVKPLPSVVRAVAEEEVL 3966
Query: 158 LTLQCNPPPGLPSPVIFWMSSSMEPITQ-DKRVSQGHNGDLYFSNVMLQDMQTDYSCNAR 216
L + + G+P P I W + T +V G G L ++ +D +Y C A
Sbjct: 3967 LPCEAS---GIPRPTITWQKEGLNVATGVSTQVLPG--GQLRIAHASPEDAG-NYLCIA- 4019
Query: 217 FHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTP 276
KN + TR V + P + G L C A G P P
Sbjct: 4020 ---------KNSAGSAMGKTRLVVQVPPVI---ENGLPDLSTTEGSHAFLPCKARGSPEP 4067
Query: 277 DIAWYKKGGDLPSDKAKFE-NFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKA 335
+I W K G + + KF + L + N+ +D+G Y C A N +G R + + +
Sbjct: 4068 NITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRARRRVHLTILV 4127
Query: 336 APYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIF 395
P + P + L G+ L C A G+P P + W VN P+ + + G T+
Sbjct: 4128 LPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEGV---SEQDGGSTLQR 4184
Query: 396 RDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFF 455
Y C N G A +FV V + P + L+ + +LDC
Sbjct: 4185 AAVSREDSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPV-GGSIQLDCVVR 4243
Query: 456 GSPIPTLRWFKNG---QGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAEN 512
G P+P + W K+G +GS+L H +NGSL I ++D G Y C+A N +G A+
Sbjct: 4244 GDPVPDIHWIKDGLPLRGSHLR----HQLQNGSLTIHRTERDDAGRYQCLAENEMGVAKK 4299
Query: 513 QVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKK 572
V L ++ P+D R G V L C+ +P+ T+ WL+ +PL R++
Sbjct: 4300 VVILVLQSAPVFQVEPQDMTVRSGDDVALRCQATGEPT--PTIEWLQAGQPLRASRRLRT 4357
Query: 573 -EDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTVLGNCPCSPW 618
D SL + V D G+Y CVA L A+A+L V G P W
Sbjct: 4358 LPDGSLWLENVETGDAGTYDCVAHNLLGSATARAFLVVRGE-PQGSW 4403
Score = 161 bits (407), Expect = 2e-39
Identities = 152/569 (26%), Positives = 241/569 (42%), Gaps = 49/569 (8%)
Query: 40 PPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTL 99
PP + A + V P + ++ C G + W R+ R A RV+ + L
Sbjct: 517 PPQLVP--APNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLP-ASTGRVA---QLADL 570
Query: 100 VIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLT 159
++ SG P + G YQC A N G ++ + L V ++P + +G +
Sbjct: 571 SLEI-SGIIPTD-GGRYQCVASNANGVTRAS-VWLLVREAPQ-VSIHTSSQHFSQGVEVK 626
Query: 160 LQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHF 219
+ C+ G P+P I W S + + +D R+ G L V +D +YSC A
Sbjct: 627 VSCSAS-GYPTPHISWSRES-QALQEDSRIHVDAQGTLIIQGVAPEDAG-NYSCQA---- 679
Query: 220 THTIQQKNPFTLKVLTTRGVAERTPSFMY---PQGTASSQMVLR--GMDLLLECIASGVP 274
T+ + G + T + Y P +A + +VL G + +L C ASGVP
Sbjct: 680 TNEV--------------GTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVP 725
Query: 275 TPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVK 334
P + WY+ G L A + + LRI E D+G Y C A N++G I + V
Sbjct: 726 PPRVIWYR--GGLEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVG 783
Query: 335 AAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMV-NGEPLQ----SAPPNPNREVA 389
AP + P+++ + G L CRA G P PTV W +G+PL + + +R+
Sbjct: 784 HAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPD 843
Query: 390 GDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTR 449
+ F +A Y C N G + A A + V P ++ +RV+
Sbjct: 844 SGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVS 903
Query: 450 LDCPFF-GSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILG 508
L C G P+P W K+G+ G + + +GSL + +E G Y+CVATN G
Sbjct: 904 LPCIVLAGRPLPERHWLKDGRPLP-PGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAG 962
Query: 509 KAENQVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYI-- 566
V L V+ P RI+ + G L C P+ T++W K+ L
Sbjct: 963 SQHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVASGVPA--PTITWTKETNALTSRG 1020
Query: 567 GNRMKKEDDSLTIFGVAERDQGSYTCVAS 595
+ ++ +L I + +D G+Y C A+
Sbjct: 1021 PHYNVSKEGTLLIAQPSAQDAGAYVCTAT 1049
Score = 156 bits (395), Expect = 5e-38
Identities = 153/604 (25%), Positives = 252/604 (41%), Gaps = 55/604 (9%)
Query: 41 PTI---TKQSAKDHIVDPRDN-ILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRS 96
PTI + SA + + +N I + CEA P+P+ W ++ F +++ ++ +
Sbjct: 2537 PTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGAPFEASRNIQL-LPGTH 2595
Query: 97 GTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNR-----IRLQVSKSPLWPKENLDPVV 151
G +++ + +E G+Y C N+ G A+ N I +SK + + V
Sbjct: 2596 GLQILNAQ-----KEDAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLGEVGVKEVK 2650
Query: 152 VQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDY 211
+ + LTL+C +P P I W +P+T R+ G L LQ T
Sbjct: 2651 TKVNSTLTLECESW-AVPPPTIRWYKDG-QPVTPSSRLQVLGEGRL------LQIQPTQV 2702
Query: 212 SCNARFHFTHT------------IQQKNPFTLKVLTTRGVAERTPSFMYPQGTASS-QMV 258
S + R+ T + Q P KV E +G + + +
Sbjct: 2703 SDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREI 2762
Query: 259 LRGMDLLLECIASGVPTPDIAWYKKGGDLPS-DKAKFENFNKALRITNVSEEDSGEYFCL 317
+ L C + +P PD+ WY++ L + D+ + L+I V E++G Y C
Sbjct: 2763 VENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCK 2822
Query: 318 ASNKMGSIRHTISVRVKAAPYWLDEPKNLI----LAPGEDGRLVCRANGNPKPTVQWMVN 373
ASN++G + V P L + + L+ + L C A GNP PT+ W+ N
Sbjct: 2823 ASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQN 2882
Query: 374 GEPLQSAPPNPNREVAGDTIIFR--DTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPR 431
G P P+P +V D + + +++ A Y C N+ G F + VPPR
Sbjct: 2883 GLPFS---PSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSA-EKLFTLRVQVPPR 2938
Query: 432 MLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMI 491
+ + + IL + L C P P + W+K+ Q +L + + +L++
Sbjct: 2939 IAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGTHTLQLGRA 2998
Query: 492 RKEDQGIYTCVATNILGKAENQVRLEVKDP---TRIYRMPEDQV-ARRGTTVQLECRVKH 547
R D G+YTC A N G+ + V+L V P + R P+D V R G L C
Sbjct: 2999 RLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCET-- 3056
Query: 548 DPSLKLTVSWLKDDEPLYIGNRMK--KEDDSLTIFGVAERDQGSYTCVASTELDQDLAKA 605
D + TV+W KD +PL + R + + L I D+G Y+C S + +
Sbjct: 3057 DALPEPTVTWYKDGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTF 3116
Query: 606 YLTV 609
LTV
Sbjct: 3117 TLTV 3120
Score = 156 bits (394), Expect = 6e-38
Identities = 152/563 (26%), Positives = 234/563 (41%), Gaps = 70/563 (12%)
Query: 57 DNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYE--- 113
D ++ CE P P+ W ++ + P V +R R G R E E
Sbjct: 3048 DKAVLSCETDALPEPTVTWYKDGQ-------PLVLAQRTQA-----LRGGQRLEIQEAQV 3095
Query: 114 ---GEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPS 170
G Y C N G A+ L V P + + V G+PL L C+ G+P+
Sbjct: 3096 SDKGLYSCKVSNVAGEAVRT-FTLTVQVPPTFENPKTETVSQVAGSPLVLTCDVS-GVPA 3153
Query: 171 PVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFT 230
P + W+ M + G L S + T Y+C A + + F
Sbjct: 3154 PTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGT-YTCVAE---NTQAEARKDFV 3209
Query: 231 LKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSD 290
+ VL VA R S G A VL G ++ L+C A G P PD+AW K G L D
Sbjct: 3210 VAVL----VAPRIRS----SGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQD 3261
Query: 291 KAKFENF---NKALRITNVSEEDSGEYFCLASNKMG--SIRHTISVRV-KAAPYWLDEPK 344
F +L + + D+G Y C+A N G + HT++V V D
Sbjct: 3262 MGPHLRFYLDGGSLVLKGLRASDAGAYTCVAHNPAGEDARLHTVNVLVPPTIKQGADGSG 3321
Query: 345 NLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREV---AGDTIIFRDTQIS 401
L+ PGE +VC G+P V W+ +G PL P R + +G T+ Q++
Sbjct: 3322 TLVSRPGELVTMVCPVRGSPPIHVSWLKDGLPL----PLSQRTLLHGSGHTLRISKVQLA 3377
Query: 402 SRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSP---RNQLIRVILYNRTRLDCPFFGSP 458
++ C ++ G N F + VPP +L P +N ++ V+ + L C G P
Sbjct: 3378 DAGIFTCVAASPAGVADRN-FTLQVQVPP-VLEPVEFQNDVV-VVRGSLVELPCEARGVP 3434
Query: 459 IPTLRWFKNGQ---GSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVR 515
+P + W K+G+ +L+ G SL+++ + D G Y+CVA + G+A +
Sbjct: 3435 LPLVSWMKDGEPLLSQSLEQG-------PSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQ 3487
Query: 516 LEVKDPTRI--YRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKE 573
L V +P I P + G ++L C + P +T W KD + L + E
Sbjct: 3488 LTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNIT--WHKDGQAL-----TRLE 3540
Query: 574 DDSLTIFGVAERDQGSYTCVAST 596
++S + RD G YTC+A +
Sbjct: 3541 NNSRATRVLRVRDAGLYTCLAES 3563
Score = 152 bits (385), Expect = 7e-37
Identities = 144/563 (25%), Positives = 229/563 (40%), Gaps = 57/563 (10%)
Query: 61 IECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFA 120
+ C A+GNP P W+++ V ++ R + F + + G Y+C A
Sbjct: 1139 LNCVAEGNPEPQLSWSKDG----------VVLQGRGPQGSVHFAAIRTSDA--GRYRCEA 1186
Query: 121 RNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQ-EGAPLTLQCNPPPGLPSPVIFWMSS- 178
N G + + L+V + P W + ++ + G +L C P G P P + W
Sbjct: 1187 SNSAGVD-AWEVELRVLEPPHWGADETSGLLERVAGENASLPC-PARGTPKPQVTWRKGP 1244
Query: 179 SMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRG 238
S EP+ V+ G L+ ++V D DY C A T ++
Sbjct: 1245 SSEPLHGQPGVAVLEEGSLFLASVSPAD-SGDYECQATNEVGSTSRRAK----------- 1292
Query: 239 VAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKK-------------GG 285
+ P + G ++ + G L LEC A+G P P+I W K G
Sbjct: 1293 LVVYVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGW 1352
Query: 286 DLPSDKA---KFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDE 342
DL + + + ++L + E DSG Y C A N+ G+ + + V P L
Sbjct: 1353 DLGWGQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGA 1412
Query: 343 --PKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQI 400
+ ++ G D L C +G P P V+W + +P+ P+ + G + + +
Sbjct: 1413 GAAQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHV 1472
Query: 401 SSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIP 460
YQC + G + + V P S + V+ + +L C G P P
Sbjct: 1473 GDEGRYQCVAFSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTP 1532
Query: 461 TLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKE--DQGIYTCVATNILGKAENQVRLEV 518
+ WFK+G + L VY G ++++ R + D G+YTC A+N +G AE RL+V
Sbjct: 1533 NITWFKDG--ALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDV 1590
Query: 519 KDPTRIY---RMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDD 575
P I P A G V LEC + PS T+SW + P+ N + E D
Sbjct: 1591 YVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPS--PTLSWHHEGLPVAESNESRLETD 1648
Query: 576 S--LTIFGVAERDQGSYTCVAST 596
L + E G Y+CVAS+
Sbjct: 1649 GSVLRLESPGEASSGLYSCVASS 1671
Score = 151 bits (382), Expect = 2e-36
Identities = 149/571 (26%), Positives = 230/571 (40%), Gaps = 37/571 (6%)
Query: 40 PPTI---TKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRS 96
PP I T++ ++ V+ + ++C A GNP P+ W +N F+ PR+ +
Sbjct: 2841 PPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFS--PSPRLQVLEDG 2898
Query: 97 GTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGA 156
L + Y C A N+ G+A L+V P +L+ V +
Sbjct: 2899 QVLQVSTAEVADA----ASYMCVAENQAGSA-EKLFTLRVQVPPRIAGLDLEQVTAILNS 2953
Query: 157 PLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNAR 216
++L C+ P+P + W S ++ L L D Y+C A
Sbjct: 2954 SVSLPCDVHAH-PNPEVTWYKDSQALSLGEEVFLLPGTHTLQLGRARLSDSGM-YTCEA- 3010
Query: 217 FHFTHTIQQKNPFTLKVLTTRGVAERTPSFMY-PQGTASSQMVLRGMDLLLECIASGVPT 275
+ + L VL P+F P+G + +V G +L C +P
Sbjct: 3011 --LNAAGRDQKLVQLSVLVP-------PAFRQAPRGPQDAVLVRVGDKAVLSCETDALPE 3061
Query: 276 PDIAWYKKGGDLP-SDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVK 334
P + WYK G L + + + + L I D G Y C SN G T ++ V+
Sbjct: 3062 PTVTWYKDGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQ 3121
Query: 335 AAPYWLDEPKNLILA--PGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDT 392
P + + PK ++ G L C +G P PTV W+ + P++S+ + G
Sbjct: 3122 VPPTF-ENPKTETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPVESSAVHGVVSRGGRL 3180
Query: 393 IIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDC 452
+ R Q + Y C N + V+VL P S + V+ RLDC
Sbjct: 3181 QLSR-LQPAQAGTYTCVAENTQAEARKDFVVAVLVAPRIRSSGVAREHHVLEGQEVRLDC 3239
Query: 453 PFFGSPIPTLRWFKNGQGSNLDGGNY--HVYENGSLEIKMIRKEDQGIYTCVATNILGKA 510
G P P + W K+G D G + + GSL +K +R D G YTCVA N G+
Sbjct: 3240 EADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVAHNPAGED 3299
Query: 511 ENQVRLEVKDPTRIYRMPEDQ---VARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIG 567
+ V P I + + V+R G V + C V+ P + VSWLKD PL +
Sbjct: 3300 ARLHTVNVLVPPTIKQGADGSGTLVSRPGELVTMVCPVRGSPPIH--VSWLKDGLPLPLS 3357
Query: 568 NR--MKKEDDSLTIFGVAERDQGSYTCVAST 596
R + +L I V D G +TCVA++
Sbjct: 3358 QRTLLHGSGHTLRISKVQLADAGIFTCVAAS 3388
Score = 150 bits (380), Expect = 3e-36
Identities = 144/580 (24%), Positives = 228/580 (39%), Gaps = 37/580 (6%)
Query: 37 LTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRS 96
L P + A++H V + ++CEA G P P W ++ P +
Sbjct: 3213 LVAPRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDG 3272
Query: 97 GTLVIDFRSGGRPEEYEGEYQCFARNKFG-TALSNRIRLQVSKSPLWPKENLDPVVVQEG 155
G+LV+ G G Y C A N G A + + + V + + +V + G
Sbjct: 3273 GSLVLK----GLRASDAGAYTCVAHNPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRPG 3328
Query: 156 APLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNA 215
+T+ C P G P + W+ + + + G L S V L D ++C A
Sbjct: 3329 ELVTMVC-PVRGSPPIHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGI-FTCVA 3386
Query: 216 RFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPT 275
+ +N FTL+V + P + P + +V+RG + L C A GVP
Sbjct: 3387 A--SPAGVADRN-FTLQV--------QVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPL 3435
Query: 276 PDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKA 335
P ++W K G L S + +L++ V DSG Y C+A ++ G R + V
Sbjct: 3436 PLVSWMKDGEPLLSQSLE---QGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVME 3492
Query: 336 APYWLD--EPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTI 393
P+ D +P L L PG L+C A G P+P + W +G+ L N
Sbjct: 3493 PPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQALTRLENNSRAT------ 3546
Query: 394 IFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRN-QLIRVILYNRTRLDC 452
R ++ +Y C + G + +F + PP ++ PR + + + + L+C
Sbjct: 3547 --RVLRVRDAGLYTCLAESPAG-AIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLVLEC 3603
Query: 453 PFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAEN 512
P P + W ++G D L+++ + D G Y+C A N G
Sbjct: 3604 SVEAEPAPKITWHRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSV 3663
Query: 513 QVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKK 572
R+E+ I P T L C+ P+ VSW KD PL + +
Sbjct: 3664 AFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPA--PLVSWRKDRVPLDPRSPRFE 3721
Query: 573 --EDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTVL 610
+ SL I V +D G Y C+AS D L VL
Sbjct: 3722 ILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVL 3761
Score = 150 bits (379), Expect = 3e-36
Identities = 148/591 (25%), Positives = 237/591 (40%), Gaps = 52/591 (8%)
Query: 40 PPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTL 99
PP IT + V + + C A G P+P+ W ++ + A P + + L
Sbjct: 1976 PPRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVL 2035
Query: 100 VIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLD-PVVVQEGAPL 158
+ + R + G Y C A + G + + LQV P E L+ VV E L
Sbjct: 2036 TL---ASARASD-SGRYSCVAVSAVGEDRQDVV-LQVHMPPSILGEELNVSVVANESVAL 2090
Query: 159 TLQCNPPPGLPSPVIFWMSSS--MEP-----ITQDKRVSQGHNGDLYFSNVMLQDMQTDY 211
Q + +P PV+ W +EP ++ DK + Q D++ + Y
Sbjct: 2091 ECQSH---AMPPPVLSWWKDGRPLEPRPGVHLSADKALLQVDRADVWDAG--------HY 2139
Query: 212 SCNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIAS 271
+C A H+ + N L V ++P + + V G L C
Sbjct: 2140 TCEALNQAGHSEKHYN---LNVWVAP---------VFPLRESHTLTVREGHPTSLSCECR 2187
Query: 272 GVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEED---SGEYFCLASNKMGSIRHT 328
GVP P I+W K G LP + A ++ + R+ + + G Y C SN +G+
Sbjct: 2188 GVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQD 2247
Query: 329 ISVRVKAAPYWL---DEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPN 385
+ + V P + P + + L C A G P PTV W +G+P+ A
Sbjct: 2248 LQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQPV-GAELGLQ 2306
Query: 386 REVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQL--IRVI 443
+ G ++ Q + Y C N G +SVL VPP ++ + L I
Sbjct: 2307 LQNQGQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVL-VPPELIGDLDPLTNITAA 2365
Query: 444 LYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVA 503
L++ L C G P P +RWF+ + + Y + L++ +++D G+Y+C+A
Sbjct: 2366 LHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLA 2425
Query: 504 TNILGKAENQVRLEVKDPTRIYRMPEDQVAR--RGTTVQLECRVKHDPSLKLTVSWLKDD 561
+N G+A +EV P I ++V + G T L C V P KLT W KD
Sbjct: 2426 SNEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLT--WFKDG 2483
Query: 562 EPLYIGNRMKKEDDS--LTIFGVAERDQGSYTCVASTELDQDLAKAYLTVL 610
PL G+ D L + G Y+C+A+ + + L+VL
Sbjct: 2484 RPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVL 2534
Score = 149 bits (376), Expect = 7e-36
Identities = 152/581 (26%), Positives = 225/581 (38%), Gaps = 38/581 (6%)
Query: 34 QNELTQPPTITKQSAKDHI-VDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSM 92
Q + +PP I + + P + + C+A+G P P+ W ++ + R+
Sbjct: 3487 QLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQALT-----RLEN 3541
Query: 93 RRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTA-LSNRIRLQVSKSPLWPKENLDPVV 151
R+ T V+ R G Y C A + G S R+R+Q + + P+ V
Sbjct: 3542 NSRA-TRVLRVRDAGL-------YTCLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVG 3593
Query: 152 VQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDY 211
+ G L L+C+ P+P I W + + +D G + DY
Sbjct: 3594 LAPGQ-LVLECSVEAE-PAPKITWHRDGIV-LQEDAHTQFPERGRFLQLQALSTADSGDY 3650
Query: 212 SCNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIAS 271
SC AR T F +++ T + P+ V LL C A
Sbjct: 3651 SCTARNAAGST---SVAFRVEIHTVPTIRSGPPAVN----------VSVNQTALLPCQAD 3697
Query: 272 GVPTPDIAWYKKGGDLPSDKAKFENFNK-ALRITNVSEEDSGEYFCLASNKMGSIRHTIS 330
GVP P ++W K L +FE + +LRI V +D+G Y CLASN GS R
Sbjct: 3698 GVPAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRD 3757
Query: 331 VRVKAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQ-SAPPNPNREVA 389
+RV P P NL L L C A+G+PKP V W +G+ L R +
Sbjct: 3758 LRVLEPPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLP 3817
Query: 390 GDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTR 449
+ ++ A ++C SNE G + + VPP + + V +
Sbjct: 3818 SNALLLTAPGPQDSAQFECVVSNEVGE-AHRLYQVTVHVPPTIADDQTD-FTVTMMAPVV 3875
Query: 450 LDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGK 509
L C G P PT+ W K G G Y V +G+LEI G YTC A N G
Sbjct: 3876 LTCHSTGIPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGV 3935
Query: 510 AENQVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIG-N 568
A V L V+ + +P A V L C P + T++W K+ + G +
Sbjct: 3936 AHKHVFLTVQASPVVKPLPSVVRAVAEEEVLLPCEASGIP--RPTITWQKEGLNVATGVS 3993
Query: 569 RMKKEDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTV 609
L I + D G+Y C+A + K L V
Sbjct: 3994 TQVLPGGQLRIAHASPEDAGNYLCIAKNSAGSAMGKTRLVV 4034
Score = 143 bits (361), Expect = 4e-34
Identities = 154/581 (26%), Positives = 236/581 (40%), Gaps = 47/581 (8%)
Query: 37 LTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRS 96
LT P + +A++ + ++ ++C G P P WT++ R + P + ++
Sbjct: 1404 LTPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTKD-RQPVLPGGPHLQVQEDG 1462
Query: 97 GTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSP-LWPKENLDPVVVQEG 155
L R G EG YQC A + G + +L+V P +W V V E
Sbjct: 1463 QVL----RITGSHVGDEGRYQCVAFSPAGQQ-ARDFQLRVHAPPTIWGSNETGEVAVMED 1517
Query: 156 APLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNA 215
+ L C G+P+P I W T K V L D Y+C A
Sbjct: 1518 HLVQLLCE-ARGVPTPNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGV-YTCKA 1575
Query: 216 RFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPT 275
N TR P+ G + G + LEC+A G P+
Sbjct: 1576 ----------SNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPS 1625
Query: 276 PDIAWYKKGGDLP---SDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVR 332
P ++W+ +G LP S++++ E LR+ + E SG Y C+AS+ G SV
Sbjct: 1626 PTLSWHHEG--LPVAESNESRLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVE 1683
Query: 333 VKAAPYWL--DEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVA- 389
V+ P L + + G+ L C+A+G+P PT+QW+ NG P + +VA
Sbjct: 1684 VQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGRPAEEL---AGVQVAS 1740
Query: 390 -GDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLD--VPPRMLSPRNQLIRVILYN 446
G T+ ++ ++ C +NE G A VSV P + P Q ++
Sbjct: 1741 QGTTLHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHH 1800
Query: 447 RT---RLDCP----FFGSPIPTL--RWFKNGQGSNLDGGNYHVYE-NGSLEIKMIRKEDQ 496
+ D P + P P L W G G Y L+I+ + D+
Sbjct: 1801 SSFPAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLPPPLQIEKVDLRDE 1860
Query: 497 GIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVS 556
GIYTC ATN+ G+++ +V L+V P I P ++ +V LEC P VS
Sbjct: 1861 GIYTCAATNLAGESKREVALKVLVPPNIEPGPVNKAVLENASVTLECLASGVP--PPDVS 1918
Query: 557 WLKDDEPL--YIGNRMKKEDDSLTIFGVAERDQGSYTCVAS 595
W K +P+ ++G + + L I D GSY CVAS
Sbjct: 1919 WFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVAS 1959
Score = 143 bits (360), Expect = 5e-34
Identities = 161/639 (25%), Positives = 241/639 (37%), Gaps = 105/639 (16%)
Query: 38 TQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSG 97
T PP+++ +A + + +L+ CEA G P P W R +A + S +
Sbjct: 695 TDPPSVSAVNAVVLVAVGEEAVLV-CEASGVPPPRVIWYRGGLEMILAPEGSSSGK---- 749
Query: 98 TLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAP 157
R E G Y C A N+ G A S I+L V +P + D V V+ G
Sbjct: 750 -----LRIPAAQERDAGTYTCRAVNELGDA-SAEIQLAVGHAPQLTELPRD-VTVELGRS 802
Query: 158 LTLQCNPPPGLPSPVIFWMSSSMEPIT------QDKRVSQGHNGDLYFSNVMLQDMQTDY 211
L C G P P + W +P+ + R Q +G L+F +V +D Q Y
Sbjct: 803 ALLACRAT-GRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPED-QAPY 860
Query: 212 SCNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIA- 270
C AR F K +++ T + S +A + VL G + L CI
Sbjct: 861 VCEARNVFG-----KVQAEARLIVTGHAPPQIAS------SAPTVRVLEGQPVSLPCIVL 909
Query: 271 SGVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTIS 330
+G P P+ W K G LP + +L + +E +G Y C+A+N GS +
Sbjct: 910 AGRPLPERHWLKDGRPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVE 969
Query: 331 VRVKAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAG 390
+ V+ P + I G L C A+G P PT+ W L S P+ N G
Sbjct: 970 LVVQVPPRIHPTATHHITNEGVPASLPCVASGVPAPTITWTKETNALTSRGPHYNVSKEG 1029
Query: 391 DTII----------------------------------------------------FRDT 398
+I
Sbjct: 1030 TLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNRLALSKYVWEEYGLLPSGSLRLAQV 1089
Query: 399 QISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSP 458
Q+ Y+C SN G ++ +V + VPP+ + P ++++V++ L+C G+P
Sbjct: 1090 QVGDSGHYECTASNPAG-SASHRYVLGVQVPPQ-VQPGPRVLKVLVGEALDLNCVAEGNP 1147
Query: 459 IPTLRWFKNG---QGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVR 515
P L W K+G QG GS+ IR D G Y C A+N G +V
Sbjct: 1148 EPQLSWSKDGVVLQGRG---------PQGSVHFAAIRTSDAGRYRCEASNSAGVDAWEVE 1198
Query: 516 LEVKDPTRIYRMPEDQVARR--GTTVQLECRVKHDPSLKLTVSWLK--DDEPLYIGNRMK 571
L V +P + R G L C + P K V+W K EPL+ +
Sbjct: 1199 LRVLEPPHWGADETSGLLERVAGENASLPCPARGTP--KPQVTWRKGPSSEPLHGQPGVA 1256
Query: 572 -KEDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTV 609
E+ SL + V+ D G Y C A+ E+ +A L V
Sbjct: 1257 VLEEGSLFLASVSPADSGDYECQATNEVGSTSRRAKLVV 1295
Score = 143 bits (360), Expect = 5e-34
Identities = 145/562 (25%), Positives = 224/562 (39%), Gaps = 45/562 (8%)
Query: 61 IECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFA 120
+ CE +G P P W ++ + + + G L+ G EG Y C
Sbjct: 2182 LSCECRGVPFPKISWRKDGQPLP-GEGAGLQHVSAVGRLLY---LGQAQLAQEGTYTCEC 2237
Query: 121 RNKFGTALSNRIRLQVSKSP--LWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSS 178
N G + S ++L+V P P+E V V + TL+CN G P P + W
Sbjct: 2238 SNVVGNS-SQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNAT-GKPPPTVTWERD 2295
Query: 179 SMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRG 238
+P+ + + + G YSC A + ++K F L VL
Sbjct: 2296 G-QPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAE-NLAGRAERK--FELSVLVP-- 2349
Query: 239 VAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDL-PSDKAKFENF 297
P + ++ L L C A G+P P I W++ + P +
Sbjct: 2350 -----PELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAG 2404
Query: 298 NKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILA--PGEDGR 355
L++T E+DSG Y CLASN+ G R SV V P +E ++ G+
Sbjct: 2405 GWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAH 2464
Query: 356 LVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQ--ISSRAVYQCNTSNE 413
L+C G+P+P + W +G PL + ++ D ++ + Q +SS Y C +N
Sbjct: 2465 LMCNVTGHPQPKLTWFKDGRPLARGDAH---HISPDGVLLQVLQANLSSAGHYSCIAANA 2521
Query: 414 HGYLLANAFVSVLDVPPRMLSPRNQL---IRVILYNRTRLDCPFFGSPIPTLRWFKNGQG 470
G + +SVL P + + + V + N L C P P + W K+G
Sbjct: 2522 VGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGAP 2581
Query: 471 SNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPED 530
+ L+I +KED G YTCV TN LG+A +EV P I + +D
Sbjct: 2582 FEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSISK--DD 2639
Query: 531 QVARRG---------TTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMK--KEDDSLTI 579
+ G +T+ LEC P T+ W KD +P+ +R++ E L I
Sbjct: 2640 PLGEVGVKEVKTKVNSTLTLECESWAVP--PPTIRWYKDGQPVTPSSRLQVLGEGRLLQI 2697
Query: 580 FGVAERDQGSYTCVASTELDQD 601
D G Y CVA+ +D
Sbjct: 2698 QPTQVSDSGRYLCVATNVAGED 2719
Score = 141 bits (356), Expect = 2e-33
Identities = 156/628 (24%), Positives = 253/628 (40%), Gaps = 86/628 (13%)
Query: 33 IQNELTQPPTIT-KQSAKDHIVDPRDNIL-IECEAKGNPAPSFHWTRNSRFFNIAKDPRV 90
+Q E+ PP I + + +D + +EC A G P P+ W R+ + + + +
Sbjct: 2248 LQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQ--PVGAELGL 2305
Query: 91 SMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKE---NL 147
++ + +L ++ + G Y C A N L+ R + S L P E +L
Sbjct: 2306 QLQNQGQSLHVERAQAA----HTGRYSCVAEN-----LAGRAERKFELSVLVPPELIGDL 2356
Query: 148 DPVVVQEGA---PLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVML 204
DP+ A PLTL C G+P P I W EP VS G + L ML
Sbjct: 2357 DPLTNITAALHSPLTLLCEAM-GIPPPAIRWFRGE-EP------VSPGEDTYLLAGGWML 2408
Query: 205 QDMQTD------YSCNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMV 258
+ QT YSC A + + F+++VL P + + V
Sbjct: 2409 KMTQTQEQDSGLYSCLAS---NEAGEARRNFSVEVLV--------PPSIENEDLEEVIKV 2457
Query: 259 LRGMDLLLECIASGVPTPDIAWYKKGGDLP-SDKAKFENFNKALRITNVSEEDSGEYFCL 317
L G L C +G P P + W+K G L D L++ + +G Y C+
Sbjct: 2458 LDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCI 2517
Query: 318 ASNKMGSIRHTISVRVKAAPYWL-----DEPKNLILAPGEDGRLVCRANGNPKPTVQWMV 372
A+N +G + V AP L + + + L+C A P P + WM
Sbjct: 2518 AANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMK 2577
Query: 373 NGEPLQSAPPNPNREVAGDT--IIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPP 430
+G P +++ N ++ T + + Q Y C +NE G + N V VL +PP
Sbjct: 2578 DGAPFEASR---NIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVL-IPP 2633
Query: 431 RMLS--PRNQL----IRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENG 484
+ P ++ ++ + + L+C + P PT+RW+K+GQ + E
Sbjct: 2634 SISKDDPLGEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGR 2693
Query: 485 SLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYR----------MPEDQVAR 534
L+I+ + D G Y CVATN+ G+ + + ++ P + + ++ AR
Sbjct: 2694 LLQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEAR 2753
Query: 535 RGTT----------VQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMK--KEDDSLTIFGV 582
G T L C P LT W ++D+PL G+ + + L I V
Sbjct: 2754 GGVTEYREIVENNPAYLYCDTNAIPPPDLT--WYREDQPLSAGDEVSVLQGGRVLQIPLV 2811
Query: 583 AERDQGSYTCVASTELDQDLAKAYLTVL 610
+ G Y+C AS E+ +D L VL
Sbjct: 2812 RAENAGRYSCKASNEVGEDWLHYELLVL 2839
Score = 140 bits (352), Expect = 5e-33
Identities = 160/647 (24%), Positives = 245/647 (37%), Gaps = 94/647 (14%)
Query: 40 PPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTL 99
PP I + +++ + L G P P HW ++ R + R S+R G+L
Sbjct: 884 PPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGR--PLPPGSRHSIRA-DGSL 940
Query: 100 VIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPV----VVQEG 155
+D +E+ G Y C A N G+ + + L V P + P + EG
Sbjct: 941 HLDRAL----QEHAGRYSCVATNTAGSQHRD-VELVVQVPP-----RIHPTATHHITNEG 990
Query: 156 APLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNA 215
P +L C G+P+P I W + ++ + G L + QD Y C A
Sbjct: 991 VPASLPC-VASGVPAPTITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGA-YVCTA 1048
Query: 216 RFHFTHTIQQKNPFTLKVLTTRGVAER---TPSFMY-------------------PQGTA 253
+ Q+ ++ ++ V E PS P G+A
Sbjct: 1049 TNTVGFSSQEMRLSVNRLALSKYVWEEYGLLPSGSLRLAQVQVGDSGHYECTASNPAGSA 1108
Query: 254 SSQMVLR------------------GMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFE 295
S + VL G L L C+A G P P ++W K G L +
Sbjct: 1109 SHRYVLGVQVPPQVQPGPRVLKVLVGEALDLNCVAEGNPEPQLSWSKDGVVLQGRGPQGS 1168
Query: 296 NFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYW-LDEPKNLI-LAPGED 353
A+R + D+G Y C ASN G + +RV P+W DE L+ GE+
Sbjct: 1169 VHFAAIRTS-----DAGRYRCEASNSAGVDAWEVELRVLEPPHWGADETSGLLERVAGEN 1223
Query: 354 GRLVCRANGNPKPTVQWM--VNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTS 411
L C A G PKP V W + EPL P E ++ + Y+C +
Sbjct: 1224 ASLPCPARGTPKPQVTWRKGPSSEPLHGQPGVAVLEEG--SLFLASVSPADSGDYECQAT 1281
Query: 412 NEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQ-- 469
NE G A + V P R + + L+C G P+P + W K+ Q
Sbjct: 1282 NEVGSTSRRAKLVVYVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLV 1341
Query: 470 -------------GSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRL 516
G GG+ + E SL I++ D G+Y+C A N G A+ L
Sbjct: 1342 GVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAGTAQRDFHL 1401
Query: 517 EVKDPTRIY--RMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGN---RMK 571
V P + ++ + G V+L+C P+ + V W KD +P+ G +++
Sbjct: 1402 LVLTPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQ--VEWTKDRQPVLPGGPHLQVQ 1459
Query: 572 KEDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTVLGNCPCSPW 618
++ L I G D+G Y CVA + Q L V + P + W
Sbjct: 1460 EDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRV--HAPPTIW 1504
Score = 137 bits (344), Expect = 4e-32
Identities = 156/620 (25%), Positives = 248/620 (40%), Gaps = 63/620 (10%)
Query: 24 AIEIPMDPSIQNELTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFN 83
++E+ + PSI+NE + H++ C G+P P W ++ R
Sbjct: 2437 SVEVLVPPSIENEDLEEVIKVLDGQTAHLM---------CNVTGHPQPKLTWFKDGRPLA 2487
Query: 84 IAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPL-- 141
+S G L+ ++ G Y C A N G + +L V +P
Sbjct: 2488 RGDAHHISP---DGVLLQVLQAN---LSSAGHYSCIAANAVGEK-TKHFQLSVLLAPTIL 2540
Query: 142 -WPKENLDP-VVVQEGAPLTLQCNPPPGLPSPVIFWMSSSME-PITQDKRVSQGHNGDLY 198
+++ D V V P++L C PSP I WM +++ ++ G +G L
Sbjct: 2541 GGAEDSADEEVTVTVNNPISLICEAL-AFPSPNITWMKDGAPFEASRNIQLLPGTHG-LQ 2598
Query: 199 FSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMV 258
N +D Y+C ++ + ++VL +++ P +++
Sbjct: 2599 ILNAQKEDAG-QYTCVVTNELGEAVKN---YHVEVLIPPSISKDDPLGEVGVKEVKTKV- 2653
Query: 259 LRGMDLLLECIASGVPTPDIAWYKKGGDL-PSDKAKFENFNKALRITNVSEEDSGEYFCL 317
L LEC + VP P I WYK G + PS + + + L+I DSG Y C+
Sbjct: 2654 --NSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCV 2711
Query: 318 ASNKMGSIRHTISVRVKAAPYWLD----EPKNLILAPGEDGR----------------LV 357
A+N G +V ++ P + IL+ E+ R L
Sbjct: 2712 ATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLY 2771
Query: 358 CRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYL 417
C N P P + W +PL SA + G + + + Y C SNE G
Sbjct: 2772 CDTNAIPPPDLTWYREDQPL-SAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVGED 2830
Query: 418 LANAFVSVLDVPPRMLSPRNQLIRVILYNRTR---LDCPFFGSPIPTLRWFKNGQGSNLD 474
+ + VL PP +L +L+ + N + L CP G+P+PT+ W +NG +
Sbjct: 2831 WLHYELLVL-TPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFS-P 2888
Query: 475 GGNYHVYENGS-LEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQV- 532
V E+G L++ D Y CVA N G AE L V+ P RI + +QV
Sbjct: 2889 SPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQVPPRIAGLDLEQVT 2948
Query: 533 ARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTI-FGVAE-RDQGSY 590
A ++V L C V P+ ++T W KD + L +G + + T+ G A D G Y
Sbjct: 2949 AILNSSVSLPCDVHAHPNPEVT--WYKDSQALSLGEEVFLLPGTHTLQLGRARLSDSGMY 3006
Query: 591 TCVASTELDQDLAKAYLTVL 610
TC A +D L+VL
Sbjct: 3007 TCEALNAAGRDQKLVQLSVL 3026
Score = 135 bits (341), Expect = 9e-32
Identities = 125/495 (25%), Positives = 203/495 (41%), Gaps = 31/495 (6%)
Query: 40 PPTITKQSAKDHIVDPR-DNILIECEAKGNPAPSFHWTRNSRFFNIAKDPR-----VSMR 93
PP+I + K ++ ++ +EC+A G P P W ++++ + +
Sbjct: 1298 PPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWG 1357
Query: 94 RRSGTLVIDF-RSGGRPEEYEGE---YQCFARNKFGTALSNRIRLQVSKSPLWPKENLDP 149
+ G ++D +S P EG+ Y C A N+ GTA + L ++ +
Sbjct: 1358 QVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGAGAAQE 1417
Query: 150 VVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQT 209
V+ GA + LQC G+P+P + W + + +G + +
Sbjct: 1418 VLGLAGADVELQCWTS-GVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEG 1476
Query: 210 DYSCNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECI 269
Y C A F+ QQ F L+V P ++ V+ + L C
Sbjct: 1477 RYQCVA---FSPAGQQARDFQLRV--------HAPPTIWGSNETGEVAVMEDHLVQLLCE 1525
Query: 270 ASGVPTPDIAWYKKGGDLP-SDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHT 328
A GVPTP+I W+K G LP S K + + L++ D+G Y C ASN +G+
Sbjct: 1526 ARGVPTPNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKA 1585
Query: 329 ISVRVKAAPYWLD---EPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPN 385
+ V P P + G L C A G+P PT+ W G P+ A N +
Sbjct: 1586 TRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEGLPV--AESNES 1643
Query: 386 R-EVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQ-LIRVI 443
R E G + +S +Y C S+ G + V V VPP++L + I
Sbjct: 1644 RLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEV-QVPPQLLVAEGLGQVTTI 1702
Query: 444 LYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVA 503
+ L C GSP+PT++W +NG+ + G + +L I + + G++ C A
Sbjct: 1703 VGQPLELPCQASGSPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQA 1762
Query: 504 TNILGKAENQVRLEV 518
TN G A +V + V
Sbjct: 1763 TNEAGTAGAEVEVSV 1777
Score = 132 bits (333), Expect = 7e-31
Identities = 153/607 (25%), Positives = 230/607 (37%), Gaps = 88/607 (14%)
Query: 25 IEIPMDPSIQNELTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNI 84
+++P + L Q TI Q + + C+A G+P P+ W +N R
Sbjct: 1684 VQVPPQLLVAEGLGQVTTIVGQPLE-----------LPCQASGSPVPTIQWLQNGR--PA 1730
Query: 85 AKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPK 144
+ V + + TL ID ++ G + C A N+ GTA + ++VS W
Sbjct: 1731 EELAGVQVASQGTTLHIDHVE----LDHSGLFACQATNEAGTAGAE---VEVSVHGEWAP 1783
Query: 145 ENLDPVVVQ------EGAPLTLQCNPP--------------PGLPSPVIFWMSSSMEPIT 184
L+ + Q + C+PP G SP W + P
Sbjct: 1784 GVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIP-- 1841
Query: 185 QDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRGVAERTP 244
V+ L V L+D + Y+C A + K LKVL +
Sbjct: 1842 ----VAYSLPPPLQIEKVDLRD-EGIYTCAAT---NLAGESKREVALKVLVPPNI----- 1888
Query: 245 SFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFN-KALRI 303
+ ++ VL + LEC+ASGVP PD++W+K + S + + + LRI
Sbjct: 1889 -----EPGPVNKAVLENASVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVLRI 1943
Query: 304 TNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDG--------R 355
D+G Y C+ASN GS +RV P + L P G R
Sbjct: 1944 EQAQLSDAGSYRCVASNVAGSTELRYGLRVNV-------PPRITLPPSLPGPVLVNTPVR 1996
Query: 356 LVCRANGNPKPTVQWMVNGEPLQSAPPNPNREV--AGDTIIFRDTQISSRAVYQCNTSNE 413
L C A G P PT+ W+ +G P+ A P +V G + + S Y C +
Sbjct: 1997 LTCNATGAPSPTLMWLKDGNPVSPA-GTPGLQVFPGGRVLTLASARASDSGRYSCVAVSA 2055
Query: 414 HGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNL 473
G + + V +PP +L + V+ L+C P P L W+K+G+
Sbjct: 2056 VGEDRQDVVLQV-HMPPSILGEELN-VSVVANESVALECQSHAMPPPVLSWWKDGRPLEP 2113
Query: 474 DGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEV-KDPTRIYRMPEDQV 532
G + + L++ D G YTC A N G +E L V P R
Sbjct: 2114 RPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGHSEKHYNLNVWVAPVFPLRESHTLT 2173
Query: 533 ARRGTTVQLECRVKHDPSLKLTVSWLKDDEPL---YIGNRMKKEDDSLTIFGVAE-RDQG 588
R G L C + P K +SW KD +PL G + L G A+ +G
Sbjct: 2174 VREGHPTSLSCECRGVPFPK--ISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEG 2231
Query: 589 SYTCVAS 595
+YTC S
Sbjct: 2232 TYTCECS 2238
Score = 132 bits (331), Expect = 1e-30
Identities = 151/582 (25%), Positives = 240/582 (41%), Gaps = 51/582 (8%)
Query: 57 DNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEY 116
+N + C A+G P P W + + P V++ G+L F + P + G+Y
Sbjct: 1222 ENASLPCPARGTPKPQVTWRKGPSSEPLHGQPGVAVLEE-GSL---FLASVSPAD-SGDY 1276
Query: 117 QCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVV-QEGAPLTLQCNPPPGLPSPVIFW 175
+C A N+ G+ S R +L V P ++ V G LTL+C+ G P P I W
Sbjct: 1277 ECQATNEVGST-SRRAKLVVYVPPSIREDGRKANVSGMAGQSLTLECDAN-GFPVPEIVW 1334
Query: 176 MSSSMEPITQDKRVSQGHNGDLYFSNV----MLQDMQTDYSCNARFHFTHTIQQKNP--F 229
+ + + G+ DL + V +L + Q+ HF IQ+ + +
Sbjct: 1335 LKDAQ--LVGVPLGWAGYGWDLGWGQVGGHRLLDEGQS-------LHFPR-IQEGDSGLY 1384
Query: 230 TLKVLTTRGVAER-------TPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYK 282
+ + G A+R TP + G A + L G D+ L+C SGVPTP + W K
Sbjct: 1385 SCRAENQAGTAQRDFHLLVLTPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTK 1444
Query: 283 -KGGDLPSDK-AKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWL 340
+ LP + + + LRIT D G Y C+A + G +RV A P
Sbjct: 1445 DRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPPTIW 1504
Query: 341 DEPKNLILAPGEDG--RLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREV---AGDTIIF 395
+ +A ED +L+C A G P P + W +G L P + V G +
Sbjct: 1505 GSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALL----PTSTKVVYTRGGRQLQL 1560
Query: 396 RDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRM--LSPRNQLIRVILYNRTRLDCP 453
Q S VY C SN G + V VPP + R +++ + L+C
Sbjct: 1561 GRAQSSDAGVYTCKASNAVGAAEKATRLDVY-VPPTIEGAGGRPYVVKAVAGRPVALECV 1619
Query: 454 FFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQ 513
G P PTL W G + + L ++ + G+Y+CVA++ G+A Q
Sbjct: 1620 ARGHPSPTLSWHHEGLPVAESNESRLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQ 1679
Query: 514 VRLEVKDPTRIYRMPE-DQVAR-RGTTVQLECRVKHDPSLKLTVSWLKDDEPL--YIGNR 569
+EV+ P ++ QV G ++L C+ P T+ WL++ P G +
Sbjct: 1680 YSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSP--VPTIQWLQNGRPAEELAGVQ 1737
Query: 570 MKKEDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTVLG 611
+ + +L I V G + C A+ E A+ ++V G
Sbjct: 1738 VASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHG 1779
Score = 121 bits (303), Expect = 2e-27
Identities = 99/373 (26%), Positives = 159/373 (42%), Gaps = 22/373 (5%)
Query: 253 ASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENF-NKALRITNVSEEDS 311
A + V G +L C G ++ W + LP+ + + +L I+ + D
Sbjct: 523 APNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDG 582
Query: 312 GEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWM 371
G Y C+ASN G R ++ + V+ AP + + G + ++ C A+G P P + W
Sbjct: 583 GRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWS 642
Query: 372 VNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPR 431
+ LQ + A T+I + Y C +NE G V++ P
Sbjct: 643 RESQALQE--DSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVG--TDQETVTLYYTDPP 698
Query: 432 MLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNL--DGGNYHVYENGSLEIK 489
+S N ++ V + L C G P P + W++ G L +G + +G L I
Sbjct: 699 SVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSS-----SGKLRIP 753
Query: 490 MIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDP 549
++ D G YTC A N LG A +++L V ++ +P D G + L CR P
Sbjct: 754 AAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRP 813
Query: 550 SLKLTVSWLKDD-EPLYI------GNRMKKEDDSLTIF-GVAERDQGSYTCVASTELDQD 601
TV+W + D +PL + G+R ++ D + F VA DQ Y C A +
Sbjct: 814 PP--TVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKV 871
Query: 602 LAKAYLTVLGNCP 614
A+A L V G+ P
Sbjct: 872 QAEARLIVTGHAP 884
Score = 119 bits (297), Expect = 1e-26
Identities = 102/396 (25%), Positives = 173/396 (43%), Gaps = 32/396 (8%)
Query: 37 LTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRS 96
+ Q P + + D + + C+A+G+P P+ W ++ + + A+ + S
Sbjct: 4033 VVQVPPVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDGQPVSGAEGKFTI--QPS 4090
Query: 97 GTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGA 156
G L++ G + G Y C A N G A R+ L + P++ D + + G
Sbjct: 4091 GELLVKNLEG----QDAGTYTCTAENAVGRA-RRRVHLTILVLPVFTTLPGDRSL-RLGD 4144
Query: 157 PLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNA- 215
L L+C G P+P I W + P+T+ VS+ G + ++ Y C A
Sbjct: 4145 RLWLRC-AARGSPTPRIGWTVND-RPVTEG--VSEQDGGSTLQRAAVSREDSGTYVCWAE 4200
Query: 216 -RFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLR-GMDLLLECIASGV 273
R T + + VL QG A S +V G + L+C+ G
Sbjct: 4201 NRVGRTQAVSFVHVKEAPVL---------------QGEAFSYLVEPVGGSIQLDCVVRGD 4245
Query: 274 PTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRV 333
P PDI W K G L + + N +L I +D+G Y CLA N+MG + + + +
Sbjct: 4246 PVPDIHWIKDGLPLRGSHLRHQLQNGSLTIHRTERDDAGRYQCLAENEMGVAKKVVILVL 4305
Query: 334 KAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTI 393
++AP + EP+++ + G+D L C+A G P PT++W+ G+PL+++ R + ++
Sbjct: 4306 QSAPVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRAS--RRLRTLPDGSL 4363
Query: 394 IFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVP 429
+ + Y C N G A AF+ V P
Sbjct: 4364 WLENVETGDAGTYDCVAHNLLGSATARAFLVVRGEP 4399
Score = 115 bits (288), Expect = 1e-25
Identities = 125/494 (25%), Positives = 193/494 (39%), Gaps = 50/494 (10%)
Query: 39 QPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGT 98
+ P ++ ++ H + + + C A G P P W+R S+ + +D R+ + + GT
Sbjct: 606 EAPQVSIHTSSQHFSQGVE-VKVSCSASGYPTPHISWSRESQA--LQEDSRIHVDAQ-GT 661
Query: 99 LVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPL 158
L+I G PE+ G Y C A N+ GT + L + P N V+V G
Sbjct: 662 LIIQ---GVAPED-AGNYSCQATNEVGTD-QETVTLYYTDPPSVSAVNA-VVLVAVGEEA 715
Query: 159 TLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFH 218
L C G+P P + W +E I + S +G L +D T Y+C A
Sbjct: 716 VLVCEAS-GVPPPRVIWYRGGLEMILAPEGSS---SGKLRIPAAQERDAGT-YTCRA--- 767
Query: 219 FTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDI 278
+ + + ++ G A + P+ V G LL C A+G P P +
Sbjct: 768 ----VNELGDASAEIQLAVGHAPQLTEL--PRDVT----VELGRSALLACRATGRPPPTV 817
Query: 279 AWYKKGGD-------LPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISV 331
W + G + + L +V+ ED Y C A N G ++ +
Sbjct: 818 TWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARL 877
Query: 332 RVK--AAPYWLDEPKNLILAPGEDGRLVCRA-NGNPKPTVQWMVNGEPLQSAPPNPNREV 388
V A P + + G+ L C G P P W+ +G PL PP +
Sbjct: 878 IVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPL---PPGSRHSI 934
Query: 389 AGDTIIFRDTQISSRAV-YQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNR 447
D + D + A Y C +N G + + V+ VPPR+ I N
Sbjct: 935 RADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVEL-VVQVPPRIHPTATHHIT----NE 989
Query: 448 ---TRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVAT 504
L C G P PT+ W K G +Y+V + G+L I +D G Y C AT
Sbjct: 990 GVPASLPCVASGVPAPTITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTAT 1049
Query: 505 NILGKAENQVRLEV 518
N +G + ++RL V
Sbjct: 1050 NTVGFSSQEMRLSV 1063
Score = 95.1 bits (235), Expect = 2e-19
Identities = 84/322 (26%), Positives = 132/322 (40%), Gaps = 12/322 (3%)
Query: 295 ENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDG 354
E+ N + I S+ + G Y C A ++ G+ R + V P L N+ ++PGE
Sbjct: 475 ESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETA 534
Query: 355 RLVCRANGNPKPTVQWMVNGEPLQSAPPNPNR--EVAGDTIIFRDTQISSRAVYQCNTSN 412
L CR G + W+ + L P + R ++A ++ + YQC SN
Sbjct: 535 VLSCRVLGEAPYNLTWVRDWRVL---PASTGRVAQLADLSLEISGIIPTDGGRYQCVASN 591
Query: 413 EHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSN 472
+G A+ ++ V + P + +Q + ++ C G P P + W + Q
Sbjct: 592 ANGVTRASVWLLVREAPQVSIHTSSQHFSQGV--EVKVSCSASGYPTPHISWSRESQALQ 649
Query: 473 LDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQV 532
D HV G+L I+ + ED G Y+C ATN +G + V L DP + + +
Sbjct: 650 ED-SRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVL 708
Query: 533 ARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAERDQGSYTC 592
G L C P + V W + + + L I ERD G+YTC
Sbjct: 709 VAVGEEAVLVCEASGVPPPR--VIWYRGGLEMILAPE-GSSSGKLRIPAAQERDAGTYTC 765
Query: 593 VASTELDQDLAKAYLTVLGNCP 614
A EL A+ L V G+ P
Sbjct: 766 RAVNELGDASAEIQLAV-GHAP 786
Score = 54.3 bits (129), Expect = 3e-07
Identities = 43/155 (27%), Positives = 62/155 (40%), Gaps = 4/155 (2%)
Query: 457 SPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRL 516
S +P + G+ + ++ N S EI K ++G Y C A + G + ++
Sbjct: 452 SALPFRLQLRRGEARLGEERHFQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQI 511
Query: 517 EVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDE--PLYIGNRMKKED 574
V DP + G T L CRV + LT W++D P G + D
Sbjct: 512 VVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLT--WVRDWRVLPASTGRVAQLAD 569
Query: 575 DSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTV 609
SL I G+ D G Y CVAS A +L V
Sbjct: 570 LSLEISGIIPTDGGRYQCVASNANGVTRASVWLLV 604
>gi|118572606 hemicentin 1 [Homo sapiens]
Length = 5635
Score = 180 bits (456), Expect = 4e-45
Identities = 165/585 (28%), Positives = 245/585 (41%), Gaps = 40/585 (6%)
Query: 39 QPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGT 98
+PP I Q ++ H++ + IL+ CEA G P+P W + N+ R SG
Sbjct: 3986 EPPVIQPQPSELHVI-LNNPILLPCEATGTPSPFITWQKEG--INVNTSGRNHAVLPSGG 4042
Query: 99 LVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPL 158
L I E G Y C A+N GTAL +I+L V P+ +L V+ P+
Sbjct: 4043 LQIS----RAVREDAGTYMCVAQNPAGTALG-KIKLNVQVPPVI-SPHLKEYVIAVDKPI 4096
Query: 159 TLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFH 218
TL C GLP P I W I + R +G L + V D Y+C A
Sbjct: 4097 TLSCEAD-GLPPPDITWHKDG-RAIVESIRQRVLSSGSLQIAFVQPGDAG-HYTCMAA-- 4151
Query: 219 FTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDI 278
N +T+ P + T V +L C+A G+PTP I
Sbjct: 4152 --------NVAGSSSTSTKLTVHVPPRI---RSTEGHYTVNENSQAILPCVADGIPTPAI 4200
Query: 279 AWYKKGGDLPSDKAKF--ENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAA 336
W K L + K+ E + + + + NV EDSG Y C+A+N G HT+S+ V
Sbjct: 4201 NWKKDNVLLANLLGKYTAEPYGELI-LENVVLEDSGFYTCVANNAAGEDTHTVSLTVHVL 4259
Query: 337 PYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGE--PLQSAPPNPNREVAGDTII 394
P + + P ++ L GE RL C+A G P P + W N P N + E+ + +
Sbjct: 4260 PTFTELPGDVSLNKGEQLRLSCKATGIPLPKLTWTFNNNIIPAHFDSVNGHSELVIERVS 4319
Query: 395 FRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPF 454
D+ Y C N G++ A FV V + P + I + N L+C
Sbjct: 4320 KEDS-----GTYVCTAENSVGFVKAIGFVYVKEPPVFKGDYPSNWIEPLGGNAI-LNCEV 4373
Query: 455 FGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQV 514
G P PT++W + G + NGSL I ED G YTCVATN G E +
Sbjct: 4374 KGDPTPTIQWNRKGVDIEISH-RIRQLGNGSLAIYGTVNEDAGDYTCVATNEAGVVERSM 4432
Query: 515 RLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMK-KE 573
L ++ P I P + V G + L C+ +P + T++W + + +R+
Sbjct: 4433 SLTLQSPPIITLEPVETVINAGGKIILNCQATGEP--QPTITWSRQGHSISWDDRVNVLS 4490
Query: 574 DDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTVLGNCPCSPW 618
++SL I + D + CVA + L + + V + S W
Sbjct: 4491 NNSLYIADAQKEDTSEFECVARNLMGSVLVRVPVIVQVHGGFSQW 4535
Score = 178 bits (451), Expect = 1e-44
Identities = 157/589 (26%), Positives = 256/589 (43%), Gaps = 60/589 (10%)
Query: 36 ELTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRN------SRFFNIAKDPR 89
++ PP ++ A D ++ N+ + C +G P P+ W R SR F+++
Sbjct: 788 DVGSPPVFIQEPA-DVSMEIGSNVTLPCYVQGYPEPTIKWRRLDNMPIFSRPFSVSS--- 843
Query: 90 VSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDP 149
+S R +++ + + G Y C A N+FG + + + V+ + P + P
Sbjct: 844 ISQLRTGALFILNLWASDK-----GTYICEAENQFGK-IQSETTVTVT-GLVAPLIGISP 896
Query: 150 VV--VQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDM 207
V V EG LTL C G P P W+ +S + Q+ ++ +G L+ V LQD
Sbjct: 897 SVANVIEGQQLTLPCTLLAGNPIPERRWIKNSAM-LLQNPYITVRSDGSLHIERVQLQD- 954
Query: 208 QTDYSCNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLE 267
+Y+C A N TT V P+ + Q S+ + G+ + L
Sbjct: 955 GGEYTCVA----------SNVAGTNNKTTSVVVHVLPTIQHGQQILST---IEGIPVTLP 1001
Query: 268 CIASGVPTPDIAWYKKGGDLPSDKAKFE-NFNKALRITNVSEEDSGEYFCLASNKMGSIR 326
C ASG P P + W KKG + + AKF + +L + + E+SGEY C A+N G +
Sbjct: 1002 CKASGNPKPSVIWSKKGELISTSSAKFSAGADGSLYVVSPGGEESGEYVCTATNTAGYAK 1061
Query: 327 HTISVRVKAAPYWL--------DEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQ 378
+ + V P D+P + + GE+ L C P P + W + +
Sbjct: 1062 RKVQLTVYVRPRVFGDQRGLSQDKPVEISVLAGEEVTLPCEVKSLPPPIITWAKETQLIS 1121
Query: 379 SAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQ 438
P +G I +T+ S +Y C +N G + ++V VPP++
Sbjct: 1122 PFSPRHTFLPSGSMKI-TETRTSDSGMYLCVATNIAGNVTQAVKLNV-HVPPKIQRGPKH 1179
Query: 439 LIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGI 498
L +V + R + C G+P+P + W K G +DG ++ +G+L I D GI
Sbjct: 1180 L-KVQVGQRVDIPCNAQGTPLPVITWSKGGSTMLVDGEHHVSNPDGTLSIDQATPSDAGI 1238
Query: 499 YTCVATNILGKAENQVRLEVKDPTRIYRMP-------EDQVARRGTTVQLECRVKHDPSL 551
YTCVATNI G E ++ L V++P + + +++VA + ++ C K P
Sbjct: 1239 YTCVATNIAGTDETEITLHVQEPPTVEDLEPPYNTTFQERVANQ--RIEFPCPAKGTP-- 1294
Query: 552 KLTVSWLKDDEPL---YIGNRMKKEDDSLTIFGVAERDQGSYTCVASTE 597
K T+ WL + L G + ++ L I V D G Y CVA E
Sbjct: 1295 KPTIKWLHNGRELTGREPGISILEDGTLLVIASVTPYDNGEYICVAVNE 1343
Score = 172 bits (435), Expect = 1e-42
Identities = 155/569 (27%), Positives = 240/569 (42%), Gaps = 42/569 (7%)
Query: 40 PPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTL 99
PPTI + +V + ++C A G P PS W ++ + N A+ +++ +S
Sbjct: 1825 PPTIKSSGLSERVVVKYKPVALQCIANGIPNPSITWLKDDQPVNTAQG---NLKIQSSGR 1881
Query: 100 VIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSP-LWPKENLDPVVVQEGAPL 158
V+ E G Y C A N G I+L V + P L + V P+
Sbjct: 1882 VLQIAK--TLLEDAGRYTCVATNAAGET-QQHIQLHVHEPPSLEDAGKMLNETVLVSNPV 1938
Query: 159 TLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFH 218
L+C G P PVI W +D R+ G + + + D+++ +A +
Sbjct: 1939 QLECKAA-GNPVPVITWY--------KDNRLLSGSTSMTFLNRGQIIDIESAQISDAGIY 1989
Query: 219 FTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDI 278
I L VA PS G+ + V+ + LEC A G+P P +
Sbjct: 1990 KCVAINSAGATELFYSLQVHVA---PSI---SGSNNMVAVVVNNPVRLECEARGIPAPSL 2043
Query: 279 AWYKKGGDLPSDKAKFENFN--KALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAA 336
W K G + S + + + L +T+ D+G Y C+A N G + I +RV
Sbjct: 2044 TWLKDGSPVSSFSNGLQVLSGGRILALTSAQISDTGRYTCVAVNAAGEKQRDIDLRVYVP 2103
Query: 337 PYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPP---NPNREVAGDTI 393
P + E +N+ + + L+C+++ P PT+ W+ +G PL P + NR V +
Sbjct: 2104 PNIMGEEQNVSVLISQAVELLCQSDAIPPPTLTWLKDGHPLLKKPGLSISENRSV----L 2159
Query: 394 IFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRM-LSPRNQLIRVILYNRTRLDC 452
D Q+ Y C +N G N V++ VPP + S + VI N L C
Sbjct: 2160 KIEDAQVQDTGRYTCEATNVAGKTEKNYNVNIW-VPPNIGGSDELTQLTVIEGNLISLLC 2218
Query: 453 PFFGSPIPTLRWFKNGQGSNLDG-GNYHVYENG-SLEIKMIRKEDQGIYTCVATNILGKA 510
G P P L W K G D G + G L+I + K D +Y+CVA+N+ G A
Sbjct: 2219 ESSGIPPPNLIWKKKGSPVLTDSMGRVRILSGGRQLQISIAEKSDAALYSCVASNVAGTA 2278
Query: 511 ENQVRLEV---KDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLY-- 565
+ + L+V T P + + RG ++ LEC V+ P TV+W+KD PL
Sbjct: 2279 KKEYNLQVYIRPTITNSGSHPTEIIVTRGKSISLECEVQGIP--PPTVTWMKDGHPLIKA 2336
Query: 566 IGNRMKKEDDSLTIFGVAERDQGSYTCVA 594
G + E L + + D G Y CVA
Sbjct: 2337 KGVEILDEGHILQLKNIHVSDTGRYVCVA 2365
Score = 168 bits (426), Expect = 1e-41
Identities = 151/576 (26%), Positives = 241/576 (41%), Gaps = 54/576 (9%)
Query: 40 PPTITKQSAKDHI-VDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGT 98
PPTI + + + V ++ +EC+ KG P P HW ++ + + DP V + R
Sbjct: 1451 PPTIIGTNFPNEVSVVLNRDVALECQVKGTPFPDIHWFKDGKPLFLG-DPNVELLDRG-- 1507
Query: 99 LVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENL-DPVVVQEGAP 157
V+ ++ R + +G YQC N G + I+L + P N+ + V +
Sbjct: 1508 QVLHLKNARRND--KGRYQCTVSNAAGKQAKD-IKLTIYIPPSIKGGNVTTDISVLINSL 1564
Query: 158 LTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARF 217
+ L+C GLP P I W ++ + + L+ + D T Y+C+
Sbjct: 1565 IKLECE-TRGLPMPAITWYKDGQPIMSSSQALYIDKGQYLHIPRAQVSDSAT-YTCH--- 1619
Query: 218 HFTHTIQQKNPFTLKVLTTRGVAERT--------PSFMYPQGTASSQMVLRGMDLLLECI 269
V G AE++ P T ++ V+ L LEC
Sbjct: 1620 ---------------VANVAGTAEKSFHVDVYVPPMIEGNLATPLNKQVVIAHSLTLECK 1664
Query: 270 ASGVPTPDIAWYKKGGDL-PSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMG--SIR 326
A+G P+P + W K G + +D + E K L I + E D G+Y C+A++ G I+
Sbjct: 1665 AAGNPSPILTWLKDGVPVKANDNIRIEAGGKKLEIMSAQEIDRGQYICVATSVAGEKEIK 1724
Query: 327 HTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNR 386
+ + V V A DE I+ L C G+P PT+ W+ +G+ L
Sbjct: 1725 YEVDVLVPPAIEGGDETSYFIVMVNNLLELDCHVTGSPPPTIMWLKDGQ-LIDERDGFKI 1783
Query: 387 EVAGDTIIFRDTQISSRAVYQC---NTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVI 443
+ G ++ Q+S+ +Y+C NT+ +H F + VPP + S V+
Sbjct: 1784 LLNGRKLVIAQAQVSNTGLYRCMAANTAGDH----KKEFEVTVHVPPTIKSSGLSERVVV 1839
Query: 444 LYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGS-LEIKMIRKEDQGIYTCV 502
Y L C G P P++ W K+ Q N GN + +G L+I ED G YTCV
Sbjct: 1840 KYKPVALQCIANGIPNPSITWLKDDQPVNTAQGNLKIQSSGRVLQIAKTLLEDAGRYTCV 1899
Query: 503 ATNILGKAENQVRLEVKDPTRIYRMPE--DQVARRGTTVQLECRVKHDPSLKLTVSWLKD 560
ATN G+ + ++L V +P + + ++ VQLEC+ +P +T W KD
Sbjct: 1900 ATNAAGETQQHIQLHVHEPPSLEDAGKMLNETVLVSNPVQLECKAAGNPVPVIT--WYKD 1957
Query: 561 DEPLYIGNRMK--KEDDSLTIFGVAERDQGSYTCVA 594
+ L M + I D G Y CVA
Sbjct: 1958 NRLLSGSTSMTFLNRGQIIDIESAQISDAGIYKCVA 1993
Score = 162 bits (410), Expect = 9e-40
Identities = 154/587 (26%), Positives = 244/587 (41%), Gaps = 42/587 (7%)
Query: 40 PPTITKQSAKDHI-VDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGT 98
PP I Q H+ V + I C A+G P P W++ + + VS GT
Sbjct: 1170 PPKI--QRGPKHLKVQVGQRVDIPCNAQGTPLPVITWSKGGSTMLVDGEHHVS--NPDGT 1225
Query: 99 LVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDP---VVVQEG 155
L ID + P + G Y C A N GT I L V + P E+L+P QE
Sbjct: 1226 LSIDQAT---PSD-AGIYTCVATNIAGTD-ETEITLHVQEPPT--VEDLEPPYNTTFQER 1278
Query: 156 AP---LTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYS 212
+ C P G P P I W+ + E ++ +S +G L + +Y
Sbjct: 1279 VANQRIEFPC-PAKGTPKPTIKWLHNGRELTGREPGISILEDGTLLVIASVTPYDNGEYI 1337
Query: 213 CNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASG 272
C A + T ++K + LKV P + + ++ VL L C G
Sbjct: 1338 CVA-VNEAGTTERK--YNLKV--------HVPPVIKDKEQVTNVSVLLNQLTNLFCEVEG 1386
Query: 273 VPTPDIAWYKKGGDLP-SDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISV 331
P+P I WYK + S + N K L++ + ED+G Y C A N G+ + ++
Sbjct: 1387 TPSPIIMWYKDNVQVTESSTIQTVNNGKILKLFRATPEDAGRYSCKAINIAGTSQKYFNI 1446
Query: 332 RVKAAPYWLDE--PKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVA 389
V P + P + + D L C+ G P P + W +G+PL PN
Sbjct: 1447 DVLVPPTIIGTNFPNEVSVVLNRDVALECQVKGTPFPDIHWFKDGKPLFLGDPNVELLDR 1506
Query: 390 GDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQL-IRVILYNRT 448
G + ++ + + + YQC SN G + +++ +PP + I V++ +
Sbjct: 1507 GQVLHLKNARRNDKGRYQCTVSNAAGKQAKDIKLTIY-IPPSIKGGNVTTDISVLINSLI 1565
Query: 449 RLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILG 508
+L+C G P+P + W+K+GQ ++ + L I + D YTC N+ G
Sbjct: 1566 KLECETRGLPMPAITWYKDGQPIMSSSQALYIDKGQYLHIPRAQVSDSATYTCHVANVAG 1625
Query: 509 KAENQVRLEVKDPTRI---YRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLY 565
AE ++V P I P ++ ++ LEC+ +PS LT WLKD P+
Sbjct: 1626 TAEKSFHVDVYVPPMIEGNLATPLNKQVVIAHSLTLECKAAGNPSPILT--WLKDGVPVK 1683
Query: 566 IGNRMKKE--DDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTVL 610
+ ++ E L I E D+G Y CVA++ + K + VL
Sbjct: 1684 ANDNIRIEAGGKKLEIMSAQEIDRGQYICVATSVAGEKEIKYEVDVL 1730
Score = 159 bits (401), Expect = 9e-39
Identities = 148/563 (26%), Positives = 233/563 (41%), Gaps = 39/563 (6%)
Query: 40 PPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTL 99
PP+I + D +V +I C A G P PS HWT+N I PR R +
Sbjct: 3896 PPSIADEPT-DFLVTKHAPAVITCTASGVPFPSIHWTKN----GIRLLPRGDGYRILSSG 3950
Query: 100 VIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLT 159
I+ + + G Y C ARN G+A + L V + P+ + + V+ P+
Sbjct: 3951 AIEILA--TQLNHAGRYTCVARNAAGSA-HRHVTLHVHEPPVIQPQPSELHVILNN-PIL 4006
Query: 160 LQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHF 219
L C G PSP I W + T + + +G L S + +D T Y C A
Sbjct: 4007 LPCE-ATGTPSPFITWQKEGINVNTSGRNHAVLPSGGLQISRAVREDAGT-YMCVA---- 4060
Query: 220 THTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIA 279
+NP L + + P + P ++ + L C A G+P PDI
Sbjct: 4061 ------QNP-AGTALGKIKLNVQVPPVISPH--LKEYVIAVDKPITLSCEADGLPPPDIT 4111
Query: 280 WYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYW 339
W+K G + + + +L+I V D+G Y C+A+N GS + + V P
Sbjct: 4112 WHKDGRAIVESIRQRVLSSGSLQIAFVQPGDAGHYTCMAANVAGSSSTSTKLTVHVPPRI 4171
Query: 340 LDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQ 399
+ + L C A+G P P + W + L + E G+ +I +
Sbjct: 4172 RSTEGHYTVNENSQAILPCVADGIPTPAINWKKDNVLLANLLGKYTAEPYGE-LILENVV 4230
Query: 400 ISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPI 459
+ Y C +N G ++V +P P + + + + RL C G P+
Sbjct: 4231 LEDSGFYTCVANNAAGEDTHTVSLTVHVLPTFTELPGD--VSLNKGEQLRLSCKATGIPL 4288
Query: 460 PTLRWFKNGQ--GSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLE 517
P L W N ++ D N H L I+ + KED G Y C A N +G + +
Sbjct: 4289 PKLTWTFNNNIIPAHFDSVNGH----SELVIERVSKEDSGTYVCTAENSVGFVKAIGFVY 4344
Query: 518 VKDPTRIYR--MPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKK-ED 574
VK+P +++ P + + G L C VK DP+ T+ W + + I +R+++ +
Sbjct: 4345 VKEPP-VFKGDYPSNWIEPLGGNAILNCEVKGDPT--PTIQWNRKGVDIEISHRIRQLGN 4401
Query: 575 DSLTIFGVAERDQGSYTCVASTE 597
SL I+G D G YTCVA+ E
Sbjct: 4402 GSLAIYGTVNEDAGDYTCVATNE 4424
Score = 154 bits (388), Expect = 3e-37
Identities = 146/586 (24%), Positives = 245/586 (41%), Gaps = 44/586 (7%)
Query: 36 ELTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRR 95
++++PP + Q + V P + ++ C + W RN R +A+ R+ R
Sbjct: 515 DVSEPPPVI-QVPNNVTVTPGERAVLTCLIISAVDYNLTWQRNDRDVRLAEPARI---RT 570
Query: 96 SGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSP---LWPKENLDPVVV 152
L ++ +S + GEY C ++ G++ ++ + L V + P + PK
Sbjct: 571 LANLSLELKSVKFNDA--GEYHCMVSSEGGSSAAS-VFLTVQEPPKVTVMPKNQS----F 623
Query: 153 QEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYS 212
G+ +++ C+ G P P I W + M I R +G L+ N +D Y
Sbjct: 624 TGGSEVSIMCSAT-GYPKPKIAWTVNDMF-IVGSHRYRMTSDGTLFIKNAAPKDAGI-YG 680
Query: 213 CNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASG 272
C A K TL+ + P M Q S +V G ++EC SG
Sbjct: 681 CLAS---NSAGTDKQNSTLRYI-------EAPKLMVVQ---SELLVALGDITVMECKTSG 727
Query: 273 VPTPDIAWYKKGGDL---PSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTI 329
+P P + W+K GDL PS + L+I + D+G+Y C+A N+ G I
Sbjct: 728 IPPPQVKWFK--GDLELRPSTFLIIDPLLGLLKIQETQDLDAGDYTCVAINEAGRATGKI 785
Query: 330 SVRVKAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQW-MVNGEPLQSAPPNPN--R 386
++ V + P ++ EP ++ + G + L C G P+PT++W ++ P+ S P + +
Sbjct: 786 TLDVGSPPVFIQEPADVSMEIGSNVTLPCYVQGYPEPTIKWRRLDNMPIFSRPFSVSSIS 845
Query: 387 EVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYN 446
++ + + S + Y C N+ G + + V+V + ++ + VI
Sbjct: 846 QLRTGALFILNLWASDKGTYICEAENQFGKIQSETTVTVTGLVAPLIGISPSVANVIEGQ 905
Query: 447 RTRLDCPFF-GSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATN 505
+ L C G+PIP RW KN L V +GSL I+ ++ +D G YTCVA+N
Sbjct: 906 QLTLPCTLLAGNPIPERRWIKN-SAMLLQNPYITVRSDGSLHIERVQLQDGGEYTCVASN 964
Query: 506 ILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLY 565
+ G + V I + G V L C+ +P K +V W K E +
Sbjct: 965 VAGTNNKTTSVVVHVLPTIQHGQQILSTIEGIPVTLPCKASGNP--KPSVIWSKKGELIS 1022
Query: 566 IGNR--MKKEDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTV 609
+ D SL + + G Y C A+ K LTV
Sbjct: 1023 TSSAKFSAGADGSLYVVSPGGEESGEYVCTATNTAGYAKRKVQLTV 1068
Score = 153 bits (386), Expect = 5e-37
Identities = 144/585 (24%), Positives = 238/585 (40%), Gaps = 37/585 (6%)
Query: 40 PPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTL 99
PP++ +++ V + I + CE G P P W +N + + + + R+ +
Sbjct: 2963 PPSVIGPKSENLTVVVNNFISLTCEVSGFPPPDLSWLKNEQPIKLNTNTLIVPGGRTLQI 3022
Query: 100 VIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPL---WPKENLDPVVVQEGA 156
+ S G GEY C A N+ G + + L V P E+L V V+EG
Sbjct: 3023 IRAKVSDG------GEYTCIAINQAGES-KKKFSLTVYVPPSIKDHDSESLSVVNVREGT 3075
Query: 157 PLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNAR 216
++L+C +P PVI W + IT+ V +G + Y C A
Sbjct: 3076 SVSLECESN-AVPPPVITWYKNG-RMITESTHVEILADGQMLHIKKAEVSDTGQYVCRA- 3132
Query: 217 FHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTP 276
+ F L V PS P+ + + + L C A+G+P P
Sbjct: 3133 --INVAGRDDKNFHLNVYVP-------PSIEGPEREVIVETISN--PVTLTCDATGIPPP 3181
Query: 277 DIAW---YKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIR--HTISV 331
IAW +K+ + S + + + L+I DSG Y C+ASN G + + +S+
Sbjct: 3182 TIAWLKNHKRIENSDSLEVRILSGGSKLQIARSQHSDSGNYTCIASNMEGKAQKYYFLSI 3241
Query: 332 RVKAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVA-G 390
+V + + P ++ + GE+ LVC ANG P P +QW+ +G+P+ S R A G
Sbjct: 3242 QVPPSVAGAEIPSDVSVLLGENVELVCNANGIPTPLIQWLKDGKPIASGETERIRVSANG 3301
Query: 391 DTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPP-RMLSPRNQLIRVILYNRTR 449
T+ S Y C +N G ++V P R + + ++
Sbjct: 3302 STLNIYGALTSDTGKYTCVATNPAGEEDRIFNLNVYVTPTIRGNKDEAEKLMTLVDTSIN 3361
Query: 450 LDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGK 509
++C G+P P + W KNG L + + I + D +YTCVA+N G
Sbjct: 3362 IECRATGTPPPQINWLKNGLPLPLSSHIRLLAAGQVIRIVRAQVSDVAVYTCVASNRAGV 3421
Query: 510 AENQVRLEVKDPTRIYRM--PEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIG 567
L+V P + E+ +G++ + C P+ +++WL+D +PL +
Sbjct: 3422 DNKHYNLQVFAPPNMDNSMGTEEITVLKGSSTSMACITDGTPA--PSMAWLRDGQPLGLD 3479
Query: 568 NRMKKEDDS--LTIFGVAERDQGSYTCVASTELDQDLAKAYLTVL 610
+ L + D G YTC+AS E + L VL
Sbjct: 3480 AHLTVSTHGMVLQLLKAETEDSGKYTCIASNEAGEVSKHFILKVL 3524
Score = 152 bits (385), Expect = 7e-37
Identities = 156/588 (26%), Positives = 238/588 (40%), Gaps = 46/588 (7%)
Query: 40 PPTITKQSAKDHIVDPRDN-ILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGT 98
PP+I + ++ IV+ N + + C+A G P P+ W +N + I + +R SG
Sbjct: 3150 PPSI-EGPEREVIVETISNPVTLTCDATGIPPPTIAWLKNHK--RIENSDSLEVRILSGG 3206
Query: 99 LVIDFRSGGRPEEYEGEYQCFARNKFGTALSNR-IRLQVSKSPLWPKENLDPVVVQEGAP 157
+ + G Y C A N G A + +QV S + D V V G
Sbjct: 3207 SKLQIARSQHSDS--GNYTCIASNMEGKAQKYYFLSIQVPPSVAGAEIPSD-VSVLLGEN 3263
Query: 158 LTLQCNPPPGLPSPVIFWMSSSMEPIT--QDKRVSQGHNGDLYFSNVMLQDMQTDYSCNA 215
+ L CN G+P+P+I W+ +PI + +R+ NG L Y+C A
Sbjct: 3264 VELVCNAN-GIPTPLIQWLKDG-KPIASGETERIRVSANGSTLNIYGALTSDTGKYTCVA 3321
Query: 216 RFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPT 275
++ F L V T P+ + A M L + +EC A+G P
Sbjct: 3322 T---NPAGEEDRIFNLNVYVT-------PTIRGNKDEAEKLMTLVDTSINIECRATGTPP 3371
Query: 276 PDIAWYKKGGDLP-SDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVK 334
P I W K G LP S + + +RI D Y C+ASN+ G +++V
Sbjct: 3372 PQINWLKNGLPLPLSSHIRLLAAGQVIRIVRAQVSDVAVYTCVASNRAGVDNKHYNLQVF 3431
Query: 335 AAPYWLDE--PKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDT 392
A P + + + + G + C +G P P++ W+ +G+PL + G
Sbjct: 3432 APPNMDNSMGTEEITVLKGSSTSMACITDGTPAPSMAWLRDGQPL-GLDAHLTVSTHGMV 3490
Query: 393 IIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDC 452
+ + Y C SNE G + + + VL+ P S ++ I VI+ N L C
Sbjct: 3491 LQLLKAETEDSGKYTCIASNEAGEVSKHFILKVLEPPHINGSEEHEEISVIVNNPLELTC 3550
Query: 453 PFFGSPIPTLRWFKNG-------QGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATN 505
G P P + W K+G Q L GG L I + ED G YTC+A++
Sbjct: 3551 IASGIPAPKMTWMKDGRPLPQTDQVQTLGGGEV-------LRISTAQVEDTGRYTCLASS 3603
Query: 506 ILGKAENQVRLEVKDPTRIYRM--PEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEP 563
G + + + V P I P D R V LEC K D ++WL++ E
Sbjct: 3604 PAGDDDKEYLVRVHVPPNIAGTDEPRDITVLRNRQVTLEC--KSDAVPPPVITWLRNGER 3661
Query: 564 LYIGNRMK--KEDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTV 609
L R++ L I D +YTCVAS + + LTV
Sbjct: 3662 LQATPRVRILSGGRYLQINNADLGDTANYTCVASNIAGKTTREFILTV 3709
Score = 152 bits (384), Expect = 9e-37
Identities = 153/576 (26%), Positives = 231/576 (40%), Gaps = 35/576 (6%)
Query: 40 PPTIT-KQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGT 98
PP I +D V + +EC++ P P W RN + PRV +
Sbjct: 3619 PPNIAGTDEPRDITVLRNRQVTLECKSDAVPPPVITWLRNGE--RLQATPRVRILSGGRY 3676
Query: 99 LVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPL 158
L I+ G Y C A N G I L V+ P K +V+
Sbjct: 3677 LQINNADLGDT----ANYTCVASNIAGKTTREFI-LTVNVPPNI-KGGPQSLVILLNKST 3730
Query: 159 TLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFH 218
L+C G+P+P I W R S NG L+ + + D Y C A +
Sbjct: 3731 VLECIAE-GVPTPRITWRKDGAVLAGNHARYSILENGFLHIQSAHVTDTGR-YLCMAT-N 3787
Query: 219 FTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDI 278
T +++ + V P + P T + V+ + L C A+G+P P I
Sbjct: 3788 AAGTDRRRIDLQVHV----------PPSIAPGPT--NMTVIVNVQTTLACEATGIPKPSI 3835
Query: 279 AWYKKGGDLPSDKAKFEN---FNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKA 335
W K G L D+ + + +L I + S +D+ Y C +N G + T+ + V+
Sbjct: 3836 NWRKNGHLLNVDQNQNSYRLLSSGSLVIISPSVDDTATYECTVTNGAGDDKRTVDLTVQV 3895
Query: 336 APYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPN-REVAGDTII 394
P DEP + ++ + C A+G P P++ W NG ++ P R ++ I
Sbjct: 3896 PPSIADEPTDFLVTKHAPAVITCTASGVPFPSIHWTKNG--IRLLPRGDGYRILSSGAIE 3953
Query: 395 FRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPF 454
TQ++ Y C N G A+ V++ P ++ P+ + VIL N L C
Sbjct: 3954 ILATQLNHAGRYTCVARNAAGS--AHRHVTLHVHEPPVIQPQPSELHVILNNPILLPCEA 4011
Query: 455 FGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQV 514
G+P P + W K G N G N+ V +G L+I +ED G Y CVA N G A ++
Sbjct: 4012 TGTPSPFITWQKEGINVNTSGRNHAVLPSGGLQISRAVREDAGTYMCVAQNPAGTALGKI 4071
Query: 515 RLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMK-KE 573
+L V+ P I ++ V + L C P +T W KD + R +
Sbjct: 4072 KLNVQVPPVISPHLKEYVIAVDKPITLSCEADGLPPPDIT--WHKDGRAIVESIRQRVLS 4129
Query: 574 DDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTV 609
SL I V D G YTC+A+ LTV
Sbjct: 4130 SGSLQIAFVQPGDAGHYTCMAANVAGSSSTSTKLTV 4165
Score = 149 bits (377), Expect = 6e-36
Identities = 163/614 (26%), Positives = 250/614 (40%), Gaps = 81/614 (13%)
Query: 41 PTITKQSAK--DHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGT 98
PTIT + + IV +I +ECE +G P P+ W ++ AK +
Sbjct: 2290 PTITNSGSHPTEIIVTRGKSISLECEVQGIPPPTVTWMKDGHPLIKAKGVEILDEGH--- 2346
Query: 99 LVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDP--VVVQEGA 156
++ ++ + G Y C A N G + L V P + P + V E
Sbjct: 2347 -ILQLKNIHVSDT--GRYVCVAVNVAGMT-DKKYDLSVHAPPSIIGNHRSPENISVVEKN 2402
Query: 157 PLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQT------D 210
++L C G+P P I W VS ++ + ML+ MQT
Sbjct: 2403 SVSLTCEAS-GIPLPSITWFKDGWP-------VSLSNSVRILSGGRMLRLMQTTMEDAGQ 2454
Query: 211 YSCNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIA 270
Y+C R +++ F L VL P + + T V + L C
Sbjct: 2455 YTCVVR---NAAGEERKIFGLSVLV--------PPHIVGENTLEDVKVKEKQSVTLTCEV 2503
Query: 271 SGVPTPDIAWYKKGGDLPSDKAK-FENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTI 329
+G P P+I W+K G L D+A + + L+ITNV +G Y CLAS+ G +
Sbjct: 2504 TGNPVPEITWHKDGQPLQEDEAHHIISGGRFLQITNVQVPHTGRYTCLASSPAGHKSRSF 2563
Query: 330 SVRVKAAPYWLD-----EPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNP 384
S+ V +P P+++ + LVC A P T+ W +G PL+S
Sbjct: 2564 SLNVFVSPTIAGVGSDGNPEDVTVILNSPTSLVCEAYSYPPATITWFKDGTPLES----- 2618
Query: 385 NREV----AGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRM-------- 432
NR + G T+ + Q + Y C +NE G ++ + V V +PP +
Sbjct: 2619 NRNIRILPGGRTLQILNAQEDNAGRYSCVATNEAGEMIKHYEVKVY-IPPIINKGDLWGP 2677
Query: 433 -LSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENG-SLEIKM 490
LSP+ I+V N L+C + P +L W+K+GQ D + ++ NG +L+IK
Sbjct: 2678 GLSPKEVKIKV--NNTLTLECEAYAIPSASLSWYKDGQPLKSDD-HVNIAANGHTLQIKE 2734
Query: 491 IRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPED----QVARRG--------TT 538
+ D G YTCVA+NI G+ E + ++ P ++ E R G
Sbjct: 2735 AQISDTGRYTCVASNIAGEDELDFDVNIQVPPSFQKLWEIGNMLDTGRNGEAKDVIINNP 2794
Query: 539 VQLECRVKHDPSLKLTVSWLKDDEPLYIGNR--MKKEDDSLTIFGVAERDQGSYTCVAST 596
+ L C P LT W KD PL ++ + L I D G YTCVA
Sbjct: 2795 ISLYCETNAAPPPTLT--WYKDGHPLTSSDKVLILPGGRVLQIPRAKVEDAGRYTCVAVN 2852
Query: 597 ELDQDLAKAYLTVL 610
E +D + + VL
Sbjct: 2853 EAGEDSLQYDVRVL 2866
Score = 138 bits (347), Expect = 2e-32
Identities = 144/577 (24%), Positives = 233/577 (40%), Gaps = 56/577 (9%)
Query: 63 CEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARN 122
CEA P + W ++ ++ R+ R+ ++ E+ G Y C A N
Sbjct: 2597 CEAYSYPPATITWFKDGTPLESNRNIRILPGGRTLQIL------NAQEDNAGRYSCVATN 2650
Query: 123 KFGTALSNR-----IRLQVSKSPLW-----PKENLDPVVVQEGAPLTLQCNPPPGLPSPV 172
+ G + + I ++K LW PKE V ++ LTL+C +PS
Sbjct: 2651 EAGEMIKHYEVKVYIPPIINKGDLWGPGLSPKE----VKIKVNNTLTLECEAY-AIPSAS 2705
Query: 173 IFWMSSSMEPITQDKRVSQGHNGD-LYFSNVMLQDMQTDYSCNA-------RFHFTHTIQ 224
+ W +P+ D V+ NG L + D Y+C A F IQ
Sbjct: 2706 LSWYKDG-QPLKSDDHVNIAANGHTLQIKEAQISDTGR-YTCVASNIAGEDELDFDVNIQ 2763
Query: 225 QKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKG 284
P + + L G + + ++ V+ + L C + P P + WYK G
Sbjct: 2764 V--PPSFQKLWEIG------NMLDTGRNGEAKDVIINNPISLYCETNAAPPPTLTWYKDG 2815
Query: 285 GDLPS-DKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWL--- 340
L S DK + L+I ED+G Y C+A N+ G VRV P
Sbjct: 2816 HPLTSSDKVLILPGGRVLQIPRAKVEDAGRYTCVAVNEAGEDSLQYDVRVLVPPIIKGAN 2875
Query: 341 -DEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTII-FRDT 398
D P+ + + + + C ++G+P P W +G+PL + ++ ++ I+ +T
Sbjct: 2876 SDLPEEVTVLVNKSALIECLSSGSPAPRNSWQKDGQPLLE--DDHHKFLSNGRILQILNT 2933
Query: 399 QISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSP 458
QI+ Y C N G ++V VPP ++ P+++ + V++ N L C G P
Sbjct: 2934 QITDIGRYVCVAENTAGSAKKYFNLNV-HVPPSVIGPKSENLTVVVNNFISLTCEVSGFP 2992
Query: 459 IPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEV 518
P L W KN Q L+ V +L+I + D G YTC+A N G+++ + L V
Sbjct: 2993 PPDLSWLKNEQPIKLNTNTLIVPGGRTLQIIRAKVSDGGEYTCIAINQAGESKKKFSLTV 3052
Query: 519 KDPTRIYRMPEDQVA----RRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMK--K 572
P I + ++ R GT+V LEC P +T W K+ + ++
Sbjct: 3053 YVPPSIKDHDSESLSVVNVREGTSVSLECESNAVPPPVIT--WYKNGRMITESTHVEILA 3110
Query: 573 EDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTV 609
+ L I D G Y C A +D +L V
Sbjct: 3111 DGQMLHIKKAEVSDTGQYVCRAINVAGRDDKNFHLNV 3147
Score = 137 bits (345), Expect = 3e-32
Identities = 141/543 (25%), Positives = 212/543 (39%), Gaps = 33/543 (6%)
Query: 63 CEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARN 122
CE +G P+P W +++ + + + +G ++ FR+ PE+ G Y C A N
Sbjct: 1382 CEVEGTPSPIIMWYKDN--VQVTESSTIQTVN-NGKILKLFRA--TPED-AGRYSCKAIN 1435
Query: 123 KFGTALSNRIRLQVSKSPLWPKENL-DPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSME 181
GT+ + V P N + V V + L+C G P P I W
Sbjct: 1436 IAGTS-QKYFNIDVLVPPTIIGTNFPNEVSVVLNRDVALECQVK-GTPFPDIHWFKDGKP 1493
Query: 182 PITQDKRVSQGHNGD-LYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRGVA 240
D V G L+ N D + Y C +Q L +
Sbjct: 1494 LFLGDPNVELLDRGQVLHLKNARRND-KGRYQCTVS---NAAGKQAKDIKLTIYIP---- 1545
Query: 241 ERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDL-PSDKAKFENFNK 299
PS T +++ + + LEC G+P P I WYK G + S +A + + +
Sbjct: 1546 ---PSIKGGNVTTDISVLINSL-IKLECETRGLPMPAITWYKDGQPIMSSSQALYIDKGQ 1601
Query: 300 ALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYW---LDEPKNLILAPGEDGRL 356
L I DS Y C +N G+ + V V P L P N + L
Sbjct: 1602 YLHIPRAQVSDSATYTCHVANVAGTAEKSFHVDVYVPPMIEGNLATPLNKQVVIAHSLTL 1661
Query: 357 VCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGY 416
C+A GNP P + W+ +G P++ A N E G + Q R Y C ++ G
Sbjct: 1662 ECKAAGNPSPILTWLKDGVPVK-ANDNIRIEAGGKKLEIMSAQEIDRGQYICVATSVAGE 1720
Query: 417 LLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGG 476
V VL P V++ N LDC GSP PT+ W K+GQ + G
Sbjct: 1721 KEIKYEVDVLVPPAIEGGDETSYFIVMVNNLLELDCHVTGSPPPTIMWLKDGQLIDERDG 1780
Query: 477 NYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMP-EDQVARR 535
+ L I + + G+Y C+A N G + + + V P I ++V +
Sbjct: 1781 FKILLNGRKLVIAQAQVSNTGLYRCMAANTAGDHKKEFEVTVHVPPTIKSSGLSERVVVK 1840
Query: 536 GTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAE---RDQGSYTC 592
V L+C P+ +T WLKDD+P+ K S + +A+ D G YTC
Sbjct: 1841 YKPVALQCIANGIPNPSIT--WLKDDQPVNTAQGNLKIQSSGRVLQIAKTLLEDAGRYTC 1898
Query: 593 VAS 595
VA+
Sbjct: 1899 VAT 1901
Score = 129 bits (325), Expect = 6e-30
Identities = 150/599 (25%), Positives = 236/599 (39%), Gaps = 47/599 (7%)
Query: 37 LTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRS 96
L P + + + +D V + ++ + CE GNP P W ++ + + + S
Sbjct: 2475 LVPPHIVGENTLEDVKVKEKQSVTLTCEVTGNPVPEITWHKDGQPLQEDEAHHII----S 2530
Query: 97 GTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSP----LWPKENLDPVVV 152
G + + P + G Y C A + G S L V SP + N + V V
Sbjct: 2531 GGRFLQITNVQVP--HTGRYTCLASSPAGHK-SRSFSLNVFVSPTIAGVGSDGNPEDVTV 2587
Query: 153 QEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYS 212
+P +L C P+ + ++ + ++ R+ G L N +D YS
Sbjct: 2588 ILNSPTSLVCEAYSYPPATITWFKDGTPLESNRNIRILPG-GRTLQILNAQ-EDNAGRYS 2645
Query: 213 CNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLR-GMDLLLECIAS 271
C A I+ + +KV + ++ G + ++ ++ L LEC A
Sbjct: 2646 CVATNEAGEMIKH---YEVKVYIPPII---NKGDLWGPGLSPKEVKIKVNNTLTLECEAY 2699
Query: 272 GVPTPDIAWYKKGGDLPS-DKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTIS 330
+P+ ++WYK G L S D L+I D+G Y C+ASN G
Sbjct: 2700 AIPSASLSWYKDGQPLKSDDHVNIAANGHTLQIKEAQISDTGRYTCVASNIAGEDELDFD 2759
Query: 331 VRVKAAPYW--LDEPKNLILAPGEDGR-----------LVCRANGNPKPTVQWMVNGEPL 377
V ++ P + L E N+ L G +G L C N P PT+ W +G PL
Sbjct: 2760 VNIQVPPSFQKLWEIGNM-LDTGRNGEAKDVIINNPISLYCETNAAPPPTLTWYKDGHPL 2818
Query: 378 QSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRN 437
S+ G + ++ Y C NE G V VL VPP + +
Sbjct: 2819 TSS-DKVLILPGGRVLQIPRAKVEDAGRYTCVAVNEAGEDSLQYDVRVL-VPPIIKGANS 2876
Query: 438 QL---IRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGS-LEIKMIRK 493
L + V++ ++C GSP P W K+GQ L+ ++ NG L+I +
Sbjct: 2877 DLPEEVTVLVNKSALIECLSSGSPAPRNSWQKDGQ-PLLEDDHHKFLSNGRILQILNTQI 2935
Query: 494 EDQGIYTCVATNILGKAENQVRLEVK-DPTRIYRMPEDQVARRGTTVQLECRVKHDPSLK 552
D G Y CVA N G A+ L V P+ I E+ + L C V P
Sbjct: 2936 TDIGRYVCVAENTAGSAKKYFNLNVHVPPSVIGPKSENLTVVVNNFISLTCEVSGFPPPD 2995
Query: 553 LTVSWLKDDEPLYIGNR--MKKEDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTV 609
L SWLK+++P+ + + +L I D G YTC+A + + K LTV
Sbjct: 2996 L--SWLKNEQPIKLNTNTLIVPGGRTLQIIRAKVSDGGEYTCIAINQAGESKKKFSLTV 3052
Score = 124 bits (312), Expect = 2e-28
Identities = 101/403 (25%), Positives = 174/403 (43%), Gaps = 22/403 (5%)
Query: 219 FTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDI 278
F I + T + T V+E P P V G +L C+ ++
Sbjct: 496 FYECIAVSSAGTGRAQTFFDVSEPPPVIQVPNNVT----VTPGERAVLTCLIISAVDYNL 551
Query: 279 AWYKKGGDLP-SDKAKFENF-NKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAA 336
W + D+ ++ A+ N +L + +V D+GEY C+ S++ GS ++ + V+
Sbjct: 552 TWQRNDRDVRLAEPARIRTLANLSLELKSVKFNDAGEYHCMVSSEGGSSAASVFLTVQEP 611
Query: 337 PYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFR 396
P PKN G + ++C A G PKP + W VN + + + R + T+ +
Sbjct: 612 PKVTVMPKNQSFTGGSEVSIMCSATGYPKPKIAWTVNDMFIVGS--HRYRMTSDGTLFIK 669
Query: 397 DTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFG 456
+ +Y C SN G N+ + ++ P M+ L V L + T ++C G
Sbjct: 670 NAAPKDAGIYGCLASNSAGTDKQNSTLRYIEAPKLMVVQSELL--VALGDITVMECKTSG 727
Query: 457 SPIPTLRWFKNGQGSNLDGGNYHVYEN--GSLEIKMIRKEDQGIYTCVATNILGKAENQV 514
P P ++WFK L + + + G L+I+ + D G YTCVA N G+A ++
Sbjct: 728 IPPPQVKWFKGDL--ELRPSTFLIIDPLLGLLKIQETQDLDAGDYTCVAINEAGRATGKI 785
Query: 515 RLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDE------PLYIGN 568
L+V P + P D G+ V L C V+ P + T+ W + D P + +
Sbjct: 786 TLDVGSPPVFIQEPADVSMEIGSNVTLPCYVQGYP--EPTIKWRRLDNMPIFSRPFSVSS 843
Query: 569 RMKKEDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTVLG 611
+ +L I + D+G+Y C A + + ++ +TV G
Sbjct: 844 ISQLRTGALFILNLWASDKGTYICEAENQFGKIQSETTVTVTG 886
Score = 101 bits (251), Expect = 2e-21
Identities = 85/337 (25%), Positives = 139/337 (41%), Gaps = 13/337 (3%)
Query: 278 IAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAP 337
+++ + G L D+ E+ + L I V+ D G Y C+A + G+ R V P
Sbjct: 461 LSFVRNGVTLGVDQYLKESASVNLDIAKVTLSDEGFYECIAVSSAGTGRAQTFFDVSEPP 520
Query: 338 YWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRD 397
+ P N+ + PGE L C + W N ++ A P R +A ++ +
Sbjct: 521 PVIQVPNNVTVTPGERAVLTCLIISAVDYNLTWQRNDRDVRLAEPARIRTLANLSLELKS 580
Query: 398 TQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGS 457
+ + Y C S+E G A+ F++V + P + P+NQ + + C G
Sbjct: 581 VKFNDAGEYHCMVSSEGGSSAASVFLTVQEPPKVTVMPKNQSFTG--GSEVSIMCSATGY 638
Query: 458 PIPTLRWFKNGQ---GSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQV 514
P P + W N GS+ Y + +G+L IK +D GIY C+A+N G +
Sbjct: 639 PKPKIAWTVNDMFIVGSH----RYRMTSDGTLFIKNAAPKDAGIYGCLASNSAGTDKQNS 694
Query: 515 RLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKED 574
L + ++ + + + G +EC+ P + V W K D L + +
Sbjct: 695 TLRYIEAPKLMVVQSELLVALGDITVMECKTSGIPPPQ--VKWFKGDLELRPSTFLIIDP 752
Query: 575 --DSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTV 609
L I + D G YTCVA E + K L V
Sbjct: 753 LLGLLKIQETQDLDAGDYTCVAINEAGRATGKITLDV 789
>gi|19743806 roundabout 1 isoform b [Homo sapiens]
Length = 1612
Score = 176 bits (446), Expect = 6e-44
Identities = 141/497 (28%), Positives = 222/497 (44%), Gaps = 35/497 (7%)
Query: 40 PPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRR--SG 97
PP I + + D IV + + C+A+G P P+ W + KD S R SG
Sbjct: 28 PPRIVEHPS-DLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSG 86
Query: 98 TLV-IDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGA 156
+L + G + EG Y C ARN G A+S+ L+V+ ++N V+V G
Sbjct: 87 SLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGE 146
Query: 157 PLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNAR 216
P ++C PP G P P I W +D+R++ G L + D Y C
Sbjct: 147 PAVMECQPPRGHPEPTISWKKDGSPLDDKDERITI-RGGKLMITYTRKSD-AGKYVCVG- 203
Query: 217 FHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTP 276
T+ + ++ ++ V ER PSF+ S+ V +C A G P P
Sbjct: 204 ---TNMVGERESEVAELT----VLER-PSFV---KRPSNLAVTVDDSAEFKCEARGDPVP 252
Query: 277 DIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAA 336
+ W K G+LP + + + + L+I V+ D G Y C+A N +G + ++ V+
Sbjct: 253 TVRWRKDDGELPKSRYEIRD-DHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEP 311
Query: 337 PYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEP---LQSAPPNPNREVA---- 389
P+++ +P++ ++A G C A GNP+P + W G PP + +
Sbjct: 312 PHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQT 371
Query: 390 GDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDV----PPRML--SPRNQLIRVI 443
GD I + Q S Y C T N G ++ A++ V DV PP ++ P NQ + V
Sbjct: 372 GDLTI-TNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAV- 429
Query: 444 LYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVA 503
L C GSP+PT+ W K+G + ENG L+I+ + D G YTC+A
Sbjct: 430 -DGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIA 488
Query: 504 TNILGKAENQVRLEVKD 520
+ G+A +EV++
Sbjct: 489 STPSGEATWSAYIEVQE 505
Score = 144 bits (362), Expect = 3e-34
Identities = 110/379 (29%), Positives = 170/379 (44%), Gaps = 31/379 (8%)
Query: 254 SSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKAL--------RITN 305
S +V +G L C A G PTP I WYK G + +DK + L RI +
Sbjct: 36 SDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVH 95
Query: 306 --VSEEDSGEYFCLASNKMG-SIRHTISVRVKAA-PYWLDEPKNLILAPGEDGRLVCRA- 360
S D G Y C+A N +G ++ H S+ V + P ++++A GE + C+
Sbjct: 96 GRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPP 155
Query: 361 NGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLAN 420
G+P+PT+ W +G PL + + G ++ T+ S Y C +N G +
Sbjct: 156 RGHPEPTISWKKDGSPLDDK--DERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERESE 213
Query: 421 -AFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYH 479
A ++VL+ P + P N + V + + C G P+PT+RW K+ L Y
Sbjct: 214 VAELTVLERPSFVKRPSN--LAVTVDDSAEFKCEARGDPVPTVRWRKDD--GELPKSRYE 269
Query: 480 VYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTV 539
+ ++ +L+I+ + D G YTCVA N++GKAE L V++P P DQV G TV
Sbjct: 270 IRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQVVALGRTV 329
Query: 540 QLECRVKHDPSLKLTVSWLKDD--------EPLYIGNRMK-KEDDSLTIFGVAERDQGSY 590
+C +P + + W ++ +P +R + LTI V D G Y
Sbjct: 330 TFQCEATGNP--QPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYY 387
Query: 591 TCVASTELDQDLAKAYLTV 609
C + KAYL V
Sbjct: 388 ICQTLNVAGSIITKAYLEV 406
Score = 142 bits (359), Expect = 7e-34
Identities = 134/504 (26%), Positives = 206/504 (40%), Gaps = 48/504 (9%)
Query: 133 RLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQG 192
RL+ P E+ ++V +G P TL C G P+P I W E + DK +
Sbjct: 21 RLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAE-GRPTPTIEWYKGG-ERVETDKDDPRS 78
Query: 193 H-----NGDLYFSNVM----LQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRGVAERT 243
H +G L+F ++ + + Y C AR + + +L+V R +
Sbjct: 79 HRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNA--SLEVAILRDDFRQN 136
Query: 244 PSFMYPQGTASSQMVLRGMDLLLECIAS-GVPTPDIAWYKKGGDLPSDKAKFENFNKALR 302
PS + MV G ++EC G P P I+W K G L + L
Sbjct: 137 PSDV---------MVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLM 187
Query: 303 ITNVSEEDSGEYFCLASNKMGSIRHTIS-VRVKAAPYWLDEPKNLILAPGEDGRLVCRAN 361
IT + D+G+Y C+ +N +G ++ + V P ++ P NL + + C A
Sbjct: 188 ITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEAR 247
Query: 362 GNPKPTVQWMVNGEPLQSAPPNPNREVAGD-TIIFRDTQISSRAVYQCNTSNEHGYLLAN 420
G+P PTV+W + L P E+ D T+ R Y C N G A+
Sbjct: 248 GDPVPTVRWRKDDGEL----PKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEAS 303
Query: 421 AFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNL------- 473
A ++V + P ++ PR+Q+ V L C G+P P + W + G + L
Sbjct: 304 ATLTVQEPPHFVVKPRDQV--VALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQ 361
Query: 474 DGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKD------PTRIYRM 527
+ V + G L I +++ D G Y C N+ G + LEV D P I +
Sbjct: 362 SSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQG 421
Query: 528 PEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYI-GNRMKK-EDDSLTIFGVAER 585
P +Q T L C P T+ W KD + +R+K+ E+ L I
Sbjct: 422 PVNQTVAVDGTFVLSCVATGSPVP--TILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLG 479
Query: 586 DQGSYTCVASTELDQDLAKAYLTV 609
D G YTC+AST + AY+ V
Sbjct: 480 DTGRYTCIASTPSGEATWSAYIEV 503
Score = 38.1 bits (87), Expect = 0.024
Identities = 29/115 (25%), Positives = 49/115 (42%), Gaps = 7/115 (6%)
Query: 39 QPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGT 98
+PP + +Q + V ++ C A G+P P+ W ++ + +D R+ + +G
Sbjct: 413 RPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVS-TQDSRIK-QLENGV 470
Query: 99 LVIDFRSGGRPEEYEGEYQCFARNKFGTAL-SNRIRLQVSKSPLWPKENLDPVVV 152
L I + G G Y C A G A S I +Q P+ P DP ++
Sbjct: 471 LQIRYAKLGD----TGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLI 521
>gi|4506569 roundabout 1 isoform a [Homo sapiens]
Length = 1651
Score = 176 bits (446), Expect = 6e-44
Identities = 141/497 (28%), Positives = 222/497 (44%), Gaps = 35/497 (7%)
Query: 40 PPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRR--SG 97
PP I + + D IV + + C+A+G P P+ W + KD S R SG
Sbjct: 67 PPRIVEHPS-DLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSG 125
Query: 98 TLV-IDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGA 156
+L + G + EG Y C ARN G A+S+ L+V+ ++N V+V G
Sbjct: 126 SLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGE 185
Query: 157 PLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNAR 216
P ++C PP G P P I W +D+R++ G L + D Y C
Sbjct: 186 PAVMECQPPRGHPEPTISWKKDGSPLDDKDERITI-RGGKLMITYTRKSD-AGKYVCVG- 242
Query: 217 FHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTP 276
T+ + ++ ++ V ER PSF+ S+ V +C A G P P
Sbjct: 243 ---TNMVGERESEVAELT----VLER-PSFV---KRPSNLAVTVDDSAEFKCEARGDPVP 291
Query: 277 DIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAA 336
+ W K G+LP + + + + L+I V+ D G Y C+A N +G + ++ V+
Sbjct: 292 TVRWRKDDGELPKSRYEIRD-DHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEP 350
Query: 337 PYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEP---LQSAPPNPNREVA---- 389
P+++ +P++ ++A G C A GNP+P + W G PP + +
Sbjct: 351 PHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQT 410
Query: 390 GDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDV----PPRML--SPRNQLIRVI 443
GD I + Q S Y C T N G ++ A++ V DV PP ++ P NQ + V
Sbjct: 411 GDLTI-TNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAV- 468
Query: 444 LYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVA 503
L C GSP+PT+ W K+G + ENG L+I+ + D G YTC+A
Sbjct: 469 -DGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIA 527
Query: 504 TNILGKAENQVRLEVKD 520
+ G+A +EV++
Sbjct: 528 STPSGEATWSAYIEVQE 544
Score = 144 bits (362), Expect = 3e-34
Identities = 110/379 (29%), Positives = 170/379 (44%), Gaps = 31/379 (8%)
Query: 254 SSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKAL--------RITN 305
S +V +G L C A G PTP I WYK G + +DK + L RI +
Sbjct: 75 SDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVH 134
Query: 306 --VSEEDSGEYFCLASNKMG-SIRHTISVRVKAA-PYWLDEPKNLILAPGEDGRLVCRA- 360
S D G Y C+A N +G ++ H S+ V + P ++++A GE + C+
Sbjct: 135 GRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPP 194
Query: 361 NGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLAN 420
G+P+PT+ W +G PL + + G ++ T+ S Y C +N G +
Sbjct: 195 RGHPEPTISWKKDGSPLDDK--DERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERESE 252
Query: 421 -AFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYH 479
A ++VL+ P + P N + V + + C G P+PT+RW K+ L Y
Sbjct: 253 VAELTVLERPSFVKRPSN--LAVTVDDSAEFKCEARGDPVPTVRWRKDD--GELPKSRYE 308
Query: 480 VYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTV 539
+ ++ +L+I+ + D G YTCVA N++GKAE L V++P P DQV G TV
Sbjct: 309 IRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQVVALGRTV 368
Query: 540 QLECRVKHDPSLKLTVSWLKDD--------EPLYIGNRMK-KEDDSLTIFGVAERDQGSY 590
+C +P + + W ++ +P +R + LTI V D G Y
Sbjct: 369 TFQCEATGNP--QPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYY 426
Query: 591 TCVASTELDQDLAKAYLTV 609
C + KAYL V
Sbjct: 427 ICQTLNVAGSIITKAYLEV 445
Score = 142 bits (359), Expect = 7e-34
Identities = 134/504 (26%), Positives = 206/504 (40%), Gaps = 48/504 (9%)
Query: 133 RLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQG 192
RL+ P E+ ++V +G P TL C G P+P I W E + DK +
Sbjct: 60 RLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAE-GRPTPTIEWYKGG-ERVETDKDDPRS 117
Query: 193 H-----NGDLYFSNVM----LQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRGVAERT 243
H +G L+F ++ + + Y C AR + + +L+V R +
Sbjct: 118 HRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNA--SLEVAILRDDFRQN 175
Query: 244 PSFMYPQGTASSQMVLRGMDLLLECIAS-GVPTPDIAWYKKGGDLPSDKAKFENFNKALR 302
PS + MV G ++EC G P P I+W K G L + L
Sbjct: 176 PSDV---------MVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLM 226
Query: 303 ITNVSEEDSGEYFCLASNKMGSIRHTIS-VRVKAAPYWLDEPKNLILAPGEDGRLVCRAN 361
IT + D+G+Y C+ +N +G ++ + V P ++ P NL + + C A
Sbjct: 227 ITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEAR 286
Query: 362 GNPKPTVQWMVNGEPLQSAPPNPNREVAGD-TIIFRDTQISSRAVYQCNTSNEHGYLLAN 420
G+P PTV+W + L P E+ D T+ R Y C N G A+
Sbjct: 287 GDPVPTVRWRKDDGEL----PKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEAS 342
Query: 421 AFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNL------- 473
A ++V + P ++ PR+Q+ V L C G+P P + W + G + L
Sbjct: 343 ATLTVQEPPHFVVKPRDQV--VALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQ 400
Query: 474 DGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKD------PTRIYRM 527
+ V + G L I +++ D G Y C N+ G + LEV D P I +
Sbjct: 401 SSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQG 460
Query: 528 PEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYI-GNRMKK-EDDSLTIFGVAER 585
P +Q T L C P T+ W KD + +R+K+ E+ L I
Sbjct: 461 PVNQTVAVDGTFVLSCVATGSPVP--TILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLG 518
Query: 586 DQGSYTCVASTELDQDLAKAYLTV 609
D G YTC+AST + AY+ V
Sbjct: 519 DTGRYTCIASTPSGEATWSAYIEV 542
Score = 38.1 bits (87), Expect = 0.024
Identities = 29/115 (25%), Positives = 49/115 (42%), Gaps = 7/115 (6%)
Query: 39 QPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGT 98
+PP + +Q + V ++ C A G+P P+ W ++ + +D R+ + +G
Sbjct: 452 RPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVS-TQDSRIK-QLENGV 509
Query: 99 LVIDFRSGGRPEEYEGEYQCFARNKFGTAL-SNRIRLQVSKSPLWPKENLDPVVV 152
L I + G G Y C A G A S I +Q P+ P DP ++
Sbjct: 510 LQIRYAKLGD----TGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLI 560
>gi|224994173 roundabout 1 isoform d [Homo sapiens]
Length = 1551
Score = 171 bits (434), Expect = 1e-42
Identities = 141/500 (28%), Positives = 222/500 (44%), Gaps = 38/500 (7%)
Query: 40 PPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRR--SG 97
PP I + + D IV + + C+A+G P P+ W + KD S R SG
Sbjct: 28 PPRIVEHPS-DLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSG 86
Query: 98 TLV-IDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGA 156
+L + G + EG Y C ARN G A+S+ L+V+ ++N V+V G
Sbjct: 87 SLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGE 146
Query: 157 PLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNAR 216
P ++C PP G P P I W +D+R++ G L + D Y C
Sbjct: 147 PAVMECQPPRGHPEPTISWKKDGSPLDDKDERITI-RGGKLMITYTRKSD-AGKYVCVG- 203
Query: 217 FHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTP 276
T+ + ++ ++ V ER PSF+ S+ V +C A G P P
Sbjct: 204 ---TNMVGERESEVAELT----VLER-PSFV---KRPSNLAVTVDDSAEFKCEARGDPVP 252
Query: 277 DIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAA 336
+ W K G+LP + + + + L+I V+ D G Y C+A N +G + ++ V+
Sbjct: 253 TVRWRKDDGELPKSRYEIRD-DHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVG 311
Query: 337 ---PYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEP---LQSAPPNPNREVA- 389
P+++ +P++ ++A G C A GNP+P + W G PP + +
Sbjct: 312 SEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSV 371
Query: 390 ---GDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDV----PPRML--SPRNQLI 440
GD I + Q S Y C T N G ++ A++ V DV PP ++ P NQ +
Sbjct: 372 SQTGDLTI-TNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTV 430
Query: 441 RVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYT 500
V L C GSP+PT+ W K+G + ENG L+I+ + D G YT
Sbjct: 431 AV--DGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYT 488
Query: 501 CVATNILGKAENQVRLEVKD 520
C+A+ G+A +EV++
Sbjct: 489 CIASTPSGEATWSAYIEVQE 508
Score = 137 bits (345), Expect = 3e-32
Identities = 134/507 (26%), Positives = 206/507 (40%), Gaps = 51/507 (10%)
Query: 133 RLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQG 192
RL+ P E+ ++V +G P TL C G P+P I W E + DK +
Sbjct: 21 RLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAE-GRPTPTIEWYKGG-ERVETDKDDPRS 78
Query: 193 H-----NGDLYFSNVM----LQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRGVAERT 243
H +G L+F ++ + + Y C AR + + +L+V R +
Sbjct: 79 HRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNA--SLEVAILRDDFRQN 136
Query: 244 PSFMYPQGTASSQMVLRGMDLLLECIAS-GVPTPDIAWYKKGGDLPSDKAKFENFNKALR 302
PS + MV G ++EC G P P I+W K G L + L
Sbjct: 137 PSDV---------MVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLM 187
Query: 303 ITNVSEEDSGEYFCLASNKMGSIRHTIS-VRVKAAPYWLDEPKNLILAPGEDGRLVCRAN 361
IT + D+G+Y C+ +N +G ++ + V P ++ P NL + + C A
Sbjct: 188 ITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEAR 247
Query: 362 GNPKPTVQWMVNGEPLQSAPPNPNREVAGD-TIIFRDTQISSRAVYQCNTSNEHGYLLAN 420
G+P PTV+W + L P E+ D T+ R Y C N G A+
Sbjct: 248 GDPVPTVRWRKDDGEL----PKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEAS 303
Query: 421 AFVSVL---DVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNL---- 473
A ++V + P ++ PR+Q+ V L C G+P P + W + G + L
Sbjct: 304 ATLTVQVGSEPPHFVVKPRDQV--VALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQ 361
Query: 474 ---DGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKD------PTRI 524
+ V + G L I +++ D G Y C N+ G + LEV D P I
Sbjct: 362 PPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVI 421
Query: 525 YRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYI-GNRMKK-EDDSLTIFGV 582
+ P +Q T L C P T+ W KD + +R+K+ E+ L I
Sbjct: 422 RQGPVNQTVAVDGTFVLSCVATGSPVP--TILWRKDGVLVSTQDSRIKQLENGVLQIRYA 479
Query: 583 AERDQGSYTCVASTELDQDLAKAYLTV 609
D G YTC+AST + AY+ V
Sbjct: 480 KLGDTGRYTCIASTPSGEATWSAYIEV 506
Score = 38.1 bits (87), Expect = 0.024
Identities = 29/115 (25%), Positives = 49/115 (42%), Gaps = 7/115 (6%)
Query: 39 QPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGT 98
+PP + +Q + V ++ C A G+P P+ W ++ + +D R+ + +G
Sbjct: 416 RPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVS-TQDSRIK-QLENGV 473
Query: 99 LVIDFRSGGRPEEYEGEYQCFARNKFGTAL-SNRIRLQVSKSPLWPKENLDPVVV 152
L I + G G Y C A G A S I +Q P+ P DP ++
Sbjct: 474 LQIRYAKLGD----TGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLI 524
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.135 0.419
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 27,100,915
Number of Sequences: 37866
Number of extensions: 1355133
Number of successful extensions: 11032
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 279
Number of HSP's successfully gapped in prelim test: 164
Number of HSP's that attempted gapping in prelim test: 3246
Number of HSP's gapped (non-prelim): 3526
length of query: 619
length of database: 18,247,518
effective HSP length: 108
effective length of query: 511
effective length of database: 14,157,990
effective search space: 7234732890
effective search space used: 7234732890
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.