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Search of human proteins with 237858621
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|237858621 polyamine modulated factor 1 binding protein 1
isoform b [Homo sapiens]
(882 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|237858621 polyamine modulated factor 1 binding protein 1 isof... 1732 0.0
gi|237858619 polyamine modulated factor 1 binding protein 1 isof... 1679 0.0
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 140 4e-33
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 140 5e-33
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 134 3e-31
gi|55770834 centromere protein F [Homo sapiens] 131 2e-30
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 131 3e-30
gi|71061468 centromere protein E [Homo sapiens] 128 3e-29
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 125 2e-28
gi|156104908 myosin heavy chain 6 [Homo sapiens] 125 2e-28
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [... 125 2e-28
gi|38044112 restin isoform b [Homo sapiens] 124 4e-28
gi|4506751 restin isoform a [Homo sapiens] 124 4e-28
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 123 9e-28
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 123 9e-28
gi|21735548 centrosomal protein 2 [Homo sapiens] 122 1e-27
gi|87298937 centrosomal protein 110kDa [Homo sapiens] 121 2e-27
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo... 121 3e-27
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ... 121 3e-27
gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo sap... 120 7e-27
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 120 7e-27
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H... 119 9e-27
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo... 119 9e-27
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo... 119 9e-27
gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo sapiens] 119 9e-27
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 118 2e-26
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 118 2e-26
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 118 2e-26
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 118 2e-26
gi|16262452 cingulin [Homo sapiens] 118 3e-26
>gi|237858621 polyamine modulated factor 1 binding protein 1 isoform
b [Homo sapiens]
Length = 882
Score = 1732 bits (4485), Expect = 0.0
Identities = 882/882 (100%), Positives = 882/882 (100%)
Query: 1 MGNHNENTGEKLHLAQEQLALAGDKIASLERSLNLYRDKYQSSLSNIELLECQVKMLQGE 60
MGNHNENTGEKLHLAQEQLALAGDKIASLERSLNLYRDKYQSSLSNIELLECQVKMLQGE
Sbjct: 1 MGNHNENTGEKLHLAQEQLALAGDKIASLERSLNLYRDKYQSSLSNIELLECQVKMLQGE 60
Query: 61 LGGIMGQEPENKGDHSKVRIYTSPCMIQEHQETQKRLSEVWQKVSQQDDLIQELRNKLAC 120
LGGIMGQEPENKGDHSKVRIYTSPCMIQEHQETQKRLSEVWQKVSQQDDLIQELRNKLAC
Sbjct: 61 LGGIMGQEPENKGDHSKVRIYTSPCMIQEHQETQKRLSEVWQKVSQQDDLIQELRNKLAC 120
Query: 121 SNALVLEREKALIKLQADFASCTATHRYPPSSSEECEDIKKILKHLQEQKDSQCLHVEEY 180
SNALVLEREKALIKLQADFASCTATHRYPPSSSEECEDIKKILKHLQEQKDSQCLHVEEY
Sbjct: 121 SNALVLEREKALIKLQADFASCTATHRYPPSSSEECEDIKKILKHLQEQKDSQCLHVEEY 180
Query: 181 QNLVKDLRVELEAVSEQKRNIMKDMMKLELDLHGLREETSAHIERKDKDITILQCRLQEL 240
QNLVKDLRVELEAVSEQKRNIMKDMMKLELDLHGLREETSAHIERKDKDITILQCRLQEL
Sbjct: 181 QNLVKDLRVELEAVSEQKRNIMKDMMKLELDLHGLREETSAHIERKDKDITILQCRLQEL 240
Query: 241 QLEFTETQKLTLKKDKFLQEKDEMLQELEKKLTQVQNSLLKKEKELEKQQCMATELEMTV 300
QLEFTETQKLTLKKDKFLQEKDEMLQELEKKLTQVQNSLLKKEKELEKQQCMATELEMTV
Sbjct: 241 QLEFTETQKLTLKKDKFLQEKDEMLQELEKKLTQVQNSLLKKEKELEKQQCMATELEMTV 300
Query: 301 KEAKQDKSKEAECKALQAEVQKLKNSLEEAKQQERLAAQQAAQCKEEAALAGCHLEDTQR 360
KEAKQDKSKEAECKALQAEVQKLKNSLEEAKQQERLAAQQAAQCKEEAALAGCHLEDTQR
Sbjct: 301 KEAKQDKSKEAECKALQAEVQKLKNSLEEAKQQERLAAQQAAQCKEEAALAGCHLEDTQR 360
Query: 361 KLQKGLLLDKQKADTIQELQRELQMLQKESSMAEKEQTSNRKRVEELSLELSEALRKLEN 420
KLQKGLLLDKQKADTIQELQRELQMLQKESSMAEKEQTSNRKRVEELSLELSEALRKLEN
Sbjct: 361 KLQKGLLLDKQKADTIQELQRELQMLQKESSMAEKEQTSNRKRVEELSLELSEALRKLEN 420
Query: 421 SDKEKRQLQKTVAEQDMKMNDMLDRIKHQHREQGSIKCKLEEDLQEATKLLEDKREQLKK 480
SDKEKRQLQKTVAEQDMKMNDMLDRIKHQHREQGSIKCKLEEDLQEATKLLEDKREQLKK
Sbjct: 421 SDKEKRQLQKTVAEQDMKMNDMLDRIKHQHREQGSIKCKLEEDLQEATKLLEDKREQLKK 480
Query: 481 SKEHEKLMEGELEALRQEFKKKDKTLKENSRKLEEENENLRAELQCCSTQLESSLNKYNT 540
SKEHEKLMEGELEALRQEFKKKDKTLKENSRKLEEENENLRAELQCCSTQLESSLNKYNT
Sbjct: 481 SKEHEKLMEGELEALRQEFKKKDKTLKENSRKLEEENENLRAELQCCSTQLESSLNKYNT 540
Query: 541 SQQVIQDLNKEIALQKESLMSLQAQLDKALQKEKHYLQTTITKEAYDALSRKSAACQDDL 600
SQQVIQDLNKEIALQKESLMSLQAQLDKALQKEKHYLQTTITKEAYDALSRKSAACQDDL
Sbjct: 541 SQQVIQDLNKEIALQKESLMSLQAQLDKALQKEKHYLQTTITKEAYDALSRKSAACQDDL 600
Query: 601 TQALEKLNHVTSETKSLQQSLTQTQEKKAQLEEEIIAYEERMKKLNTELRKLRGFHQESE 660
TQALEKLNHVTSETKSLQQSLTQTQEKKAQLEEEIIAYEERMKKLNTELRKLRGFHQESE
Sbjct: 601 TQALEKLNHVTSETKSLQQSLTQTQEKKAQLEEEIIAYEERMKKLNTELRKLRGFHQESE 660
Query: 661 LEVHAFDKKLEEMSCQVLQWQKQHQNDLKMLAAKEEQLREFQEEMAALKENLLEDDKEPC 720
LEVHAFDKKLEEMSCQVLQWQKQHQNDLKMLAAKEEQLREFQEEMAALKENLLEDDKEPC
Sbjct: 661 LEVHAFDKKLEEMSCQVLQWQKQHQNDLKMLAAKEEQLREFQEEMAALKENLLEDDKEPC 720
Query: 721 CLPQWSVPKDTCRLYRGNDQIMTNLEQWAKQQKVANEKLGNQLREQVKYIAKLSGEKDRE 780
CLPQWSVPKDTCRLYRGNDQIMTNLEQWAKQQKVANEKLGNQLREQVKYIAKLSGEKDRE
Sbjct: 721 CLPQWSVPKDTCRLYRGNDQIMTNLEQWAKQQKVANEKLGNQLREQVKYIAKLSGEKDRE 780
Query: 781 PTRASSPNTTRPSSPSHSHLHSVMVHLQQENKKLKKEIEEKKMKAENTRLCTKALGPSRT 840
PTRASSPNTTRPSSPSHSHLHSVMVHLQQENKKLKKEIEEKKMKAENTRLCTKALGPSRT
Sbjct: 781 PTRASSPNTTRPSSPSHSHLHSVMVHLQQENKKLKKEIEEKKMKAENTRLCTKALGPSRT 840
Query: 841 ESTQREKVCGTLGWKGLPQDMGQRMDLTKYIGMPHCPGSSYC 882
ESTQREKVCGTLGWKGLPQDMGQRMDLTKYIGMPHCPGSSYC
Sbjct: 841 ESTQREKVCGTLGWKGLPQDMGQRMDLTKYIGMPHCPGSSYC 882
>gi|237858619 polyamine modulated factor 1 binding protein 1 isoform a
[Homo sapiens]
Length = 1007
Score = 1679 bits (4349), Expect = 0.0
Identities = 862/882 (97%), Positives = 862/882 (97%), Gaps = 20/882 (2%)
Query: 1 MGNHNENTGEKLHLAQEQLALAGDKIASLERSLNLYRDKYQSSLSNIELLECQVKMLQGE 60
MGNHNENTGEKLHLAQEQLALAGDKIASLERSLNLYRDKYQSSLSNIELLECQVKMLQGE
Sbjct: 146 MGNHNENTGEKLHLAQEQLALAGDKIASLERSLNLYRDKYQSSLSNIELLECQVKMLQGE 205
Query: 61 LGGIMGQEPENKGDHSKVRIYTSPCMIQEHQETQKRLSEVWQKVSQQDDLIQELRNKLAC 120
LGGIMGQEPENKGDHSKVRIYTSPCMIQEHQETQKRLSEVWQKVSQQDDLIQELRNKLAC
Sbjct: 206 LGGIMGQEPENKGDHSKVRIYTSPCMIQEHQETQKRLSEVWQKVSQQDDLIQELRNKLAC 265
Query: 121 SNALVLEREKALIKLQADFASCTATHRYPPSSSEECEDIKKILKHLQEQKDSQCLHVEEY 180
SNALVLEREKALIKLQADFASCTATHRYPPSSSEECEDIKKILKHLQEQKDSQCLHVEEY
Sbjct: 266 SNALVLEREKALIKLQADFASCTATHRYPPSSSEECEDIKKILKHLQEQKDSQCLHVEEY 325
Query: 181 QNLVKDLRVELEAVSEQKRNIMKDMMKLELDLHGLREETSAHIERKDKDITILQCRLQEL 240
QNLVKDLRVELEAVSEQKRNIMKDMMKLELDLHGLREETSAHIERKDKDITILQCRLQEL
Sbjct: 326 QNLVKDLRVELEAVSEQKRNIMKDMMKLELDLHGLREETSAHIERKDKDITILQCRLQEL 385
Query: 241 QLEFTETQKLTLKKDKFLQEKDEMLQELEKKLTQVQNSLLKKEKELEKQQCMATELEMTV 300
QLEFTETQKLTLKKDKFLQEKDEMLQELEKKLTQVQNSLLKKEKELEKQQCMATELEMTV
Sbjct: 386 QLEFTETQKLTLKKDKFLQEKDEMLQELEKKLTQVQNSLLKKEKELEKQQCMATELEMTV 445
Query: 301 KEAKQDKSKEAECKALQAEVQKLKNSLEEAKQQERLAAQQAAQCKEEAALAGCHLEDTQR 360
KEAKQDKSKEAECKALQAEVQKLKNSLEEAKQQERLAAQQAAQCKEEAALAGCHLEDTQR
Sbjct: 446 KEAKQDKSKEAECKALQAEVQKLKNSLEEAKQQERLAAQQAAQCKEEAALAGCHLEDTQR 505
Query: 361 KLQKGLLLDKQKADTIQELQRELQMLQKESSMAEKEQTSNRKRVEELSLELSEALRKLEN 420
KLQKGLLLDKQKADTIQELQRELQMLQKESSMAEKEQTSNRKRVEELSLELSEALRKLEN
Sbjct: 506 KLQKGLLLDKQKADTIQELQRELQMLQKESSMAEKEQTSNRKRVEELSLELSEALRKLEN 565
Query: 421 SDKEKRQLQKTVAEQDMKMNDMLDRIKHQHREQGSIKCKLEEDLQEATKLLEDKREQLKK 480
SDKEKRQLQKTVAEQDMKMNDMLDRIKHQHREQGSIKCKLEEDLQEATKLLEDKREQLKK
Sbjct: 566 SDKEKRQLQKTVAEQDMKMNDMLDRIKHQHREQGSIKCKLEEDLQEATKLLEDKREQLKK 625
Query: 481 SKEHEKLMEGELEALRQEFKKKDKTLKENSRKLEEENENLRAELQCCSTQLESSLNKYNT 540
SKEHEKLMEGELEALRQEFKKKDKTLKENSRKLEEENENLRAELQCCSTQLESSLNKYNT
Sbjct: 626 SKEHEKLMEGELEALRQEFKKKDKTLKENSRKLEEENENLRAELQCCSTQLESSLNKYNT 685
Query: 541 SQQVIQDLNKEIALQKESLMSLQAQLDKALQKEKHYLQTTITKEAYDALSRKSAACQDDL 600
SQQVIQDLNKEIALQKESLMSLQAQLDKALQKEKHYLQTTITKEAYDALSRKSAACQDDL
Sbjct: 686 SQQVIQDLNKEIALQKESLMSLQAQLDKALQKEKHYLQTTITKEAYDALSRKSAACQDDL 745
Query: 601 TQALEKLNHVTSETKSLQQSLTQTQEKKAQLEEEIIAYEERMKKLNTELRKLRGFHQESE 660
TQALEKLNHVTSETKSLQQSLTQTQEKKAQLEEEIIAYEERMKKLNTELRKLRGFHQESE
Sbjct: 746 TQALEKLNHVTSETKSLQQSLTQTQEKKAQLEEEIIAYEERMKKLNTELRKLRGFHQESE 805
Query: 661 LEVHAFDKKLEEMSCQVLQWQKQHQNDLKMLAAKEEQLREFQEEMAALKENLLEDDKEPC 720
LEVHAFDKKLEEMSCQVLQWQKQHQNDLKMLAAKEEQLREFQEEMAALKENLLEDDKEPC
Sbjct: 806 LEVHAFDKKLEEMSCQVLQWQKQHQNDLKMLAAKEEQLREFQEEMAALKENLLEDDKEPC 865
Query: 721 CLPQWSVPKDTCRLYRGNDQIMTNLEQWAKQQKVANEKLGNQLREQVKYIAKLSGEKDRE 780
CLPQWSVPKDTCRLYRGNDQIMTNLEQWAKQQKVANEKLGNQLREQVKYIAKLSGEKD
Sbjct: 866 CLPQWSVPKDTCRLYRGNDQIMTNLEQWAKQQKVANEKLGNQLREQVKYIAKLSGEKD-- 923
Query: 781 PTRASSPNTTRPSSPSHSHLHSVMVHLQQENKKLKKEIEEKKMKAENTRLCTKALGPSRT 840
HLHSVMVHLQQENKKLKKEIEEKKMKAENTRLCTKALGPSRT
Sbjct: 924 ------------------HLHSVMVHLQQENKKLKKEIEEKKMKAENTRLCTKALGPSRT 965
Query: 841 ESTQREKVCGTLGWKGLPQDMGQRMDLTKYIGMPHCPGSSYC 882
ESTQREKVCGTLGWKGLPQDMGQRMDLTKYIGMPHCPGSSYC
Sbjct: 966 ESTQREKVCGTLGWKGLPQDMGQRMDLTKYIGMPHCPGSSYC 1007
Score = 82.0 bits (201), Expect = 2e-15
Identities = 124/677 (18%), Positives = 274/677 (40%), Gaps = 91/677 (13%)
Query: 226 KDKDITILQCRLQELQLEFTETQKLTLKKDKFLQEKD----------------------- 262
+D++++ L +L LQL+ + ++ K LQ+
Sbjct: 8 RDREVSSLNSKLLSLQLDIKNLHDVCKRQRKTLQDNQLCMEEAMNSSHDKKQAQALAFEE 67
Query: 263 -------------EMLQELEKKLTQVQNSLLKKEKELEKQQCMATELEMTVKEAKQD-KS 308
LQ+L+KKL +Q L +EL+ + + +++ D
Sbjct: 68 SEVEFGSSKQCHLRQLQQLKKKLLVLQQELEFHTEELQTSYYSLRQYQSILEKQTSDLVL 127
Query: 309 KEAECKALQAEVQKLKNSLEEAKQQERLAAQQAAQCKEEAALAGCHLEDTQRKLQKGLLL 368
CK + EV + EE ++ +E+ ALAG + +R L L
Sbjct: 128 LHHHCKLKEDEVILYE---EEMGNHNENTGEKLHLAQEQLALAGDKIASLERSL--NLYR 182
Query: 369 DKQKA--DTIQELQRELQMLQKESSMAEKEQTSNRKRVEELSLELSEA-LRKLENSDKEK 425
DK ++ I+ L+ +++MLQ E ++ N+ ++ + S +++ + + K
Sbjct: 183 DKYQSSLSNIELLECQVKMLQGELGGIMGQEPENKGDHSKVRIYTSPCMIQEHQETQKRL 242
Query: 426 RQLQKTVAEQDMKMNDMLDRIKHQH-----REQGSIKCKLE---------------EDLQ 465
++ + V++QD + ++ +++ + RE+ IK + + E+ +
Sbjct: 243 SEVWQKVSQQDDLIQELRNKLACSNALVLEREKALIKLQADFASCTATHRYPPSSSEECE 302
Query: 466 EATKLLEDKREQLKKSKEHEKLMEGELEALRQEFKKKDKTLKENSRKLEEENENLRAELQ 525
+ K+L+ +EQ K+ + L E + L ++ + + + + E R + ++ L +L
Sbjct: 303 DIKKILKHLQEQ----KDSQCLHVEEYQNLVKDLRVELEAVSEQKRNIMKDMMKLELDLH 358
Query: 526 CCSTQLESSLNKYNTSQQVIQDLNKEIALQKESLMSLQAQLDKALQKEKHYLQTTITKEA 585
+ + + + + ++Q +E+ L+ L + DK LQ++ LQ
Sbjct: 359 GLREETSAHIERKDKDITILQCRLQELQLEFTETQKLTLKKDKFLQEKDEMLQ------- 411
Query: 586 YDALSRKSAACQDDLTQALEKLNHVTSETKSLQQSLTQTQEKKAQLEEEIIAYEERMKKL 645
L +K Q+ L + ++L L+ ++ + ++ K++ E E A + ++KL
Sbjct: 412 --ELEKKLTQVQNSLLKKEKELEKQQCMATELEMTVKEAKQDKSK-EAECKALQAEVQKL 468
Query: 646 NTELRKLRGFHQESELEVHAFDKKLEEMSCQVLQWQKQHQNDLKMLAAKEEQLREFQEEM 705
L + + + + + ++ C + Q++ Q L + K + ++E Q E+
Sbjct: 469 KNSLEEAKQQERLAAQQAAQCKEEAALAGCHLEDTQRKLQKGLLLDKQKADTIQELQREL 528
Query: 706 AALKENLLEDDKEPCC----LPQWSVP-KDTCRLYRGNDQIMTNLEQWAKQQKVAN---- 756
L++ +KE + + S+ + R +D+ L++ +Q +
Sbjct: 529 QMLQKESSMAEKEQTSNRKRVEELSLELSEALRKLENSDKEKRQLQKTVAEQDMKMNDML 588
Query: 757 EKLGNQLREQVKYIAKLSGEKDREPTRASSPNTTRPSSPSHSHL-HSVMVHLQQENKKLK 815
+++ +Q REQ KL + S H L + L+QE KK
Sbjct: 589 DRIKHQHREQGSIKCKLEEDLQEATKLLEDKREQLKKSKEHEKLMEGELEALRQEFKKKD 648
Query: 816 KEIEE--KKMKAENTRL 830
K ++E +K++ EN L
Sbjct: 649 KTLKENSRKLEEENENL 665
Score = 76.3 bits (186), Expect = 1e-13
Identities = 121/594 (20%), Positives = 247/594 (41%), Gaps = 87/594 (14%)
Query: 281 KKEKELEKQQCMATELEMTVKEAKQD-KSKEAECKALQAEVQKLKNSLEEAKQQERLAAQ 339
++++E+ L++ +K K + + Q +++ NS + KQ + LA +
Sbjct: 7 ERDREVSSLNSKLLSLQLDIKNLHDVCKRQRKTLQDNQLCMEEAMNSSHDKKQAQALAFE 66
Query: 340 QAAQCKEEAALAGCHLEDTQRKLQKGLLLDKQKADTIQELQRELQMLQKESSMAEKEQTS 399
++ E + CHL Q+ +K L+L ++ +ELQ L++ S+ EK QTS
Sbjct: 67 ESEV--EFGSSKQCHLRQLQQLKKKLLVLQQELEFHTEELQTSYYSLRQYQSILEK-QTS 123
Query: 400 N--------RKRVEELSLELSEALRKLENSDKEKRQLQKTVAEQDMKMNDMLDRIKHQHR 451
+ + + +E+ L E EN+ ++ Q+ +A K+ L+R + +R
Sbjct: 124 DLVLLHHHCKLKEDEVILYEEEMGNHNENTGEKLHLAQEQLALAGDKIAS-LERSLNLYR 182
Query: 452 EQGSIKCKLEEDLQEATKLLEDK-----REQLKKSKEHEKLMEGELEALRQEFKKKDKTL 506
++ E L+ K+L+ + ++ + +H K+ + QE ++ K L
Sbjct: 183 DKYQSSLSNIELLECQVKMLQGELGGIMGQEPENKGDHSKVRIYTSPCMIQEHQETQKRL 242
Query: 507 KENSRKLEEENENLRAELQCCSTQLESSLNKYNTSQQVIQDLNKEIALQKESLMSLQAQL 566
E +K+ ++++ +IQ+L ++A +L +
Sbjct: 243 SEVWQKVSQQDD-------------------------LIQELRNKLACSN----ALVLER 273
Query: 567 DKALQKEKHYLQTTITKEAYDALSRKSAACQDDLTQALEKLNHVTSETKSLQQSLTQTQE 626
+KAL K + + Y S S C+D + L H+ + S + + Q
Sbjct: 274 EKALIKLQADFASCTATHRYPPSS--SEECED----IKKILKHLQEQKDSQCLHVEEYQN 327
Query: 627 KKAQLEEEIIAYEERMKKLNTELRK----LRGFHQESELEVHAFDK-------KLEEMSC 675
L E+ A E+ + + ++ K L G +E+ + DK +L+E+
Sbjct: 328 LVKDLRVELEAVSEQKRNIMKDMMKLELDLHGLREETSAHIERKDKDITILQCRLQELQL 387
Query: 676 QVLQWQKQHQNDLKMLAAKEEQLREFQEEMAALKENLLEDDKEPCCLPQWSVPKDTCRLY 735
+ + QK K L K+E L+E ++++ ++ +LL+ +KE + K C
Sbjct: 388 EFTETQKLTLKKDKFLQEKDEMLQELEKKLTQVQNSLLKKEKE--------LEKQQC--- 436
Query: 736 RGNDQIMTNLEQWAKQQKVANEKLG--NQLREQVKYIAKLSGEKDREPTRASSPNTTRPS 793
+ T LE K+ K K L+ +V+ + K S E+ ++ R ++ + +
Sbjct: 437 -----MATELEMTVKEAKQDKSKEAECKALQAEVQKL-KNSLEEAKQQERLAA----QQA 486
Query: 794 SPSHSHLHSVMVHLQQENKKLKKEIEEKKMKAENTRLCTKALGPSRTESTQREK 847
+ HL+ +KL+K + K KA+ + + L + ES+ EK
Sbjct: 487 AQCKEEAALAGCHLEDTQRKLQKGLLLDKQKADTIQELQRELQMLQKESSMAEK 540
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 140 bits (354), Expect = 4e-33
Identities = 200/874 (22%), Positives = 375/874 (42%), Gaps = 110/874 (12%)
Query: 2 GNHNENTGEK-LHLAQEQLALAGDKIASLERSLNLYRDKYQSSLSNIELLECQVKMLQGE 60
GN + + GE L L ++ + L ++ L+ SL +K+ S EL + Q
Sbjct: 67 GNDSGHGGESNLALKRDDVTLLRQEVQDLQASLK--EEKWYSEELKKELEKYQ------- 117
Query: 61 LGGIMGQE--PENKGDHSKVRIYTSPCMIQEHQETQ---KRLSEVW-QKVSQQDDLIQEL 114
G+ QE P+ S + + ++E Q K++ +++ QK +Q I ++
Sbjct: 118 --GLQQQEAKPDGLVTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADI 175
Query: 115 RNKLACSNALVLEREKALIKL------QADFASCTATHRYPPSSSEECEDIKKILKHLQE 168
++K +L E+ + +L +A T E+ +KK L +Q
Sbjct: 176 KSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQT 235
Query: 169 QKDSQCLHVEEYQNLVKDLRVELEAVSEQKRNIMKDMMKLELDLHGLREETSAHIERKDK 228
D+ L E +KD E + + Q + + +L +L +E + +++ K
Sbjct: 236 LMDNMTLERERESEKLKD---ECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQK 292
Query: 229 DITILQCRLQEL-QLEFTETQKLTLKKDKFLQEKDEMLQELEKKLTQVQNSLLKKEKELE 287
L+ + EL Q T T+ L LKK++ + +E E +Q +L +K+ + +
Sbjct: 293 ----LKSSVNELTQKNQTLTENL-LKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQ 347
Query: 288 KQQCMATELEMTVKEAKQDKSKEAECKALQAEVQKLKNSLEEAK---QQERLAAQQAAQC 344
+ Q + E ++ + S++ E QKLK L E + Q + +Q Q
Sbjct: 348 QLQSRLSASETSLHRIHVELSEKGEA------TQKLKEELSEVETKYQHLKAEFKQLQQQ 401
Query: 345 KEEAALAGCHLEDTQRKLQKGLLLDKQKADTIQELQRELQMLQKESSMAEKEQTSNRKRV 404
+EE G L+ +L LL +++ +E + L E M +++Q V
Sbjct: 402 REEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQ------V 455
Query: 405 EELSLELSEALRKLENSDKEKRQLQKTVAEQDMKMNDMLDRIKHQHREQGSIK----CKL 460
+L L+LS +LE KEK ++ LD+ K QH+EQ +++ KL
Sbjct: 456 ADLQLKLS----RLEEQLKEK-------VTNSTELQHQLDKTKQQHQEQQALQQSTTAKL 504
Query: 461 EE---DLQEATKLLEDKREQ-------LKKSKEHEKLMEGELE-------------ALRQ 497
E DL++ + + DK ++ L+KSKE+ L+E E E A+
Sbjct: 505 REAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLN 564
Query: 498 EFKKKDKTLKENSRKLEEE-----------NENLRAELQCCSTQLESSLNKYNTSQQVIQ 546
+ ++K+ TL+E +L E+ ENL ++Q L ++ ++ + + +
Sbjct: 565 QLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVN 624
Query: 547 DLNKEIALQKESLMSLQAQLDKALQKEKHYLQTTITKEAYDA-LSRKSAACQDDLTQALE 605
+LN ++ KE + L Q+ K + L K A A L Q+ L +
Sbjct: 625 ELNSQLNESKEKVSQLDIQIK---AKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQ 681
Query: 606 KLNHVTSETKSLQQSLTQTQEKKAQLEEEIIAYEERMKKLNTELRKLRGFHQESELEVHA 665
+LN +T++ + L QE +QLE + Y+E+ L + +L G Q +LE +
Sbjct: 682 ELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEG--QIKKLEADS 739
Query: 666 FD-KKLEEMSCQVLQWQKQHQNDLKMLAAKEEQLREFQEEMAALKENLLEDDKEPCCLPQ 724
+ K +E + Q LQ Q+Q DL++ A + + E ++E+ + L+ E
Sbjct: 740 LEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEAL---- 795
Query: 725 WSVPKDTCRLYRGNDQIMTNLEQWAKQQKVANEKLGNQLREQVKYIAKLSGEKDREPTRA 784
S+ + + + + E +++ K+ +E+L N+++ V + K+ EK+ T
Sbjct: 796 ESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTEL 855
Query: 785 SSPNTTRPSSPSHSHLHSVMVHLQQENKKLKKEI 818
S+ + S S S L + ++EN+K K I
Sbjct: 856 STVK-DKLSKVSDS-LKNSKSEFEKENQKGKAAI 887
Score = 123 bits (308), Expect = 9e-28
Identities = 169/862 (19%), Positives = 359/862 (41%), Gaps = 115/862 (13%)
Query: 12 LHLAQEQLALAGDKIASLERSLNLYRDKYQSSLSNIELLECQVKMLQGELGGIMGQEPEN 71
LH +L+ G+ L+ L+ KYQ L+ + K LQ Q+ E
Sbjct: 360 LHRIHVELSEKGEATQKLKEELSEVETKYQH-------LKAEFKQLQ--------QQREE 404
Query: 72 KGDHSKVRIYTSPCMIQEHQETQKRLSEVWQKVSQQDDLIQELRNKLACSNALVLEREKA 131
K H + + ET+++L E ++ +Q L S+ ++++E+
Sbjct: 405 KEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQL----------SSEKLMDKEQQ 454
Query: 132 LIKLQADFASCTATHRYPPSSSEECEDIKKILKHLQEQKDSQCLHVEEYQNLVKDLRVEL 191
+ LQ + + ++S E LQ Q D +E Q L + +L
Sbjct: 455 VADLQLKLSRLEEQLKEKVTNSTE----------LQHQLDKTKQQHQEQQALQQSTTAKL 504
Query: 192 EAVSEQKRNIMKDMMKLELDLHGLREETSAHIERKDKDITILQCRLQELQLEFTETQKLT 251
+++ + + + L A +++ ++I++L+ ++L + + T
Sbjct: 505 REAQNDLEQVLRQIGDKDQKIQNLE----ALLQKSKENISLLEKEREDLYAKIQAGEGET 560
Query: 252 LKKDKFLQEKDEMLQELEKKLTQVQNSLLKKEKELEKQQCMATELEMTVKEAKQD-KSKE 310
++ LQEK+ LQE +LT+ LK + E KQ L V+E K ++ +
Sbjct: 561 AVLNQ-LQEKNHTLQEQVTQLTEK----LKNQSESHKQA--QENLHDQVQEQKAHLRAAQ 613
Query: 311 AECKALQAEVQKLKNSLEEAKQQ------------ERLAAQQAAQCKEEAALAGCHLEDT 358
+L+ V +L + L E+K++ E L + +AA+ + A L HL+
Sbjct: 614 DRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQN-HLDTA 672
Query: 359 QRKLQKGLLLDKQK-----ADTIQELQRELQMLQKESSMAE---KEQTSNRKRVEELSLE 410
Q LQ DKQ+ + ++ +LQ Q+ S E KE +E+ + E
Sbjct: 673 QNALQ-----DKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEE 727
Query: 411 LSEALRKLENSDKEKRQLQKTVAEQDMKMNDMLDRIKHQHREQGSIKCKLEE-------- 462
L ++KLE +D + + K A QD++ L+ + S + ++E+
Sbjct: 728 LEGQIKKLE-ADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRL 786
Query: 463 DLQEATKLLEDKREQLKKSKEHEKLMEGELEALRQEFKKKDKTLKENSRKLEEENENLRA 522
DLQ+ ++ LE +++L K +E +++++ + E L QE K + + L + E + ++
Sbjct: 787 DLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKM 846
Query: 523 ELQCCSTQLESSLNKYNTSQQVIQDLNKEIALQKESLMSLQAQLDKALQKEKHYLQTTIT 582
E + T+L + +K + +++ E + + + L+K ++ KH LQ +
Sbjct: 847 EKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQME 906
Query: 583 KEAYDALS-RKSAACQDDLTQALE-KLNHVTSETKSLQQSLTQTQEKKAQLEEEIIAYEE 640
+ +KS + + + L+ +LN + + Q +L Q ++++ QL+ I ++
Sbjct: 907 NTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQ 966
Query: 641 RMKKLNTELRKLRGFHQESELEVHAFDKKLEEMSCQVLQWQKQHQNDLKML----AAKEE 696
++ ++ L+G + + L+ + KL++ Q Q + + +L +E
Sbjct: 967 SSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQE 1026
Query: 697 QLREFQEEMAALKENLLEDDKEPCCLPQWSVPKDTCRLYRGNDQIMTNLEQWAKQQKVAN 756
++ Q + + LL ++ + + +L + +++N Q Q K+
Sbjct: 1027 TFKQLQSDFYGRESELLATRQDLKSVEE--------KLSLAQEDLISNRNQIGNQNKLIQ 1078
Query: 757 E-------------KLGNQLREQVKYIAKLSGEKDREPTRASSPNTTRPSSPSHSHLHSV 803
E K QL+E+ K + + EK + + + + + +
Sbjct: 1079 ELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKS------KLAEIEEI 1132
Query: 804 MVHLQQENKKLKKEIEEKKMKA 825
++E KL +E++ K+++
Sbjct: 1133 KCRQEKEITKLNEELKSHKLES 1154
Score = 91.7 bits (226), Expect = 3e-18
Identities = 144/655 (21%), Positives = 281/655 (42%), Gaps = 107/655 (16%)
Query: 17 EQLALAGDKIASLERSLNLYRDKYQSSLSNIELLECQVKMLQGELGGIMGQEPENKGDHS 76
+QL + + ++S L + +S + E + ++L+ + + QE + + +
Sbjct: 772 KQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFE-TLSQETKIQHEEL 830
Query: 77 KVRIYTSPCMIQ----EHQETQKRLSEVWQKVSQQDDLIQELRNKLACSN----ALVLER 128
RI T+ +Q E + LS V K+S+ D ++ +++ N A +L+
Sbjct: 831 NNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDL 890
Query: 129 EKALIKLQADFASCTATHRYPPSSSEECEDIKKILKHLQEQKDSQCLHVEEYQNLVKDLR 188
EK +L+ H+ ++ K++ K L+++K++ L+
Sbjct: 891 EKTCKELK---------HQLQVQMENTLKEQKELKKSLEKEKEAS-----------HQLK 930
Query: 189 VELEAVSEQ---KRNIMKDMMKLELDLHGLREETSAHIERKDKDITILQCRLQELQLEFT 245
+EL ++ EQ +N +K K E L G E E+K K I LQ L+ L+ T
Sbjct: 931 LELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKT 990
Query: 246 ETQKLTLKKDKFLQEKDEMLQEL---EKKLTQVQNSLLKKEKELEKQQCMATELEMTVKE 302
E + +K Q+ + QEL ++K++ +QN+ K ++ ++ Q E +
Sbjct: 991 ELE------NKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLA 1044
Query: 303 AKQDKSKEAECKALQAEVQKLKNSLEEAKQQERLAAQQAAQCKEEAALAGCHLEDTQRKL 362
+QD K E K A+ + N + Q + + +E A LE K
Sbjct: 1045 TRQDL-KSVEEKLSLAQEDLISNRNQIGNQNKLI---------QELKTAKATLEQDSAKK 1094
Query: 363 QKGLLLDKQKADTIQELQRELQMLQKE-----SSMAEKEQTSNR------KRVEELSLEL 411
++ L +++ +Q++Q+E + +KE S +AE E+ R K EEL
Sbjct: 1095 EQQL---QERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHK 1151
Query: 412 SEALRKLENSDKEKRQLQKTVAEQDMKMNDMLDRIKHQHREQGSIKCKLEEDLQEATKLL 471
E+++++ N K+ L + E K + + ++ + R Q +K +++++ +E K
Sbjct: 1152 LESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEF 1211
Query: 472 EDKREQLKKSKEHEKLMEGELEALRQEFKKKDKT-----LKENSRKLEEENENLRAELQC 526
+K +L H ++ E E+ + E + T L EN +++E
Sbjct: 1212 IEKEAKL-----HSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKE---------- 1256
Query: 527 CSTQLESSLNKYNTSQQVIQDLNKEIALQKESLMSLQ----AQLDKALQKEKHY--LQTT 580
+SS + + ++ DL EIA+ + ++ + Q A L++ L+ E LQT
Sbjct: 1257 ----WQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTK 1312
Query: 581 ITKEAYDALSRKSAACQDDLTQALEKLNHVTSETKSLQQSLTQTQEKKAQLEEEI 635
+ + L RK D+ T A+++L E +SLQ TQ +K + E+
Sbjct: 1313 VLE-----LQRK----LDNTTAAVQELGR---ENQSLQIKHTQALNRKWAEDNEV 1355
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 140 bits (353), Expect = 5e-33
Identities = 201/892 (22%), Positives = 409/892 (45%), Gaps = 130/892 (14%)
Query: 9 GEKLHLAQEQLALAGDKIASLERSLNLYRDKYQSSLSNIELLECQVKMLQGELGGIMGQE 68
G L +EQL ++ +ERSL+ YR KY ++ ++L+ + K LQG L
Sbjct: 129 GNSDSLNKEQLI---QRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGIL------- 178
Query: 69 PENKGDHSKVRIYTSPCMIQEHQETQKRLSEVWQ-KVSQQDDLIQELRNKLAC------S 121
D S RI +Q Q+ +K L E + + ++D I L+ +++ +
Sbjct: 179 -SQSQDKSLRRIAELREELQMDQQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQRLRN 237
Query: 122 NALVLEREKALIKLQADFASCTATHRYPPSSSE---ECEDIKKILKHLQEQKDSQ----- 173
+ ++ K L +L+ A P S E E K L+ LQ++ Q
Sbjct: 238 GPMNVDVLKPLPQLEPQ-AEVFTKEENPESDGEPVVEDGTSVKTLETLQQRVKRQENLLK 296
Query: 174 -CLH-VEEYQNLVKDLRVELEAVSEQKRNIMKDMMKLELDLHGLREETSAHIERKDKDIT 231
C ++ ++ L E EA+ EQ ++++ K++ DLH + E+T + +D
Sbjct: 297 RCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIK-DLH-MAEKTKLITQLRDAKNL 354
Query: 232 ILQCRLQELQLEFTETQKLTLKKDKFLQEKDEMLQELEKKLTQV--QNSLLKKEKELEKQ 289
I Q Q+ + ET++ + + L+ K+E + +L ++ Q+ Q L+++KE + +
Sbjct: 355 IEQLE-QDKGMVIAETKR---QMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKE-KSE 409
Query: 290 QCMATELEMTVKEAKQDKSKEAECKALQAEVQKLKNSLEEAKQQERLAAQQ-AAQCKEEA 348
+ ELE + A+ K++EA K L+AE+ + ++E+ ++ER++ QQ ++ K+E
Sbjct: 410 RAAFEELEKALSTAQ--KTEEARRK-LKAEMDEQIKTIEKTSEEERISLQQELSRVKQEV 466
Query: 349 A-LAGCHLEDTQRKLQKGLLLDKQKADTIQELQRELQMLQK----------ESSMAEKEQ 397
+ E+ KLQK L +K+ A QEL ++LQ ++ E S +E +
Sbjct: 467 VDVMKKSSEEQIAKLQK--LHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLK 524
Query: 398 TSNRKR------VEELSLELSEALRKLENSDKEKRQLQKTVAEQDMKMNDMLDRIKHQHR 451
S K +EEL L+ L + EN ++ +Q +T + +++ L++ +++
Sbjct: 525 ISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENK 584
Query: 452 EQGS-----IKCKLEEDLQEATKLLEDKREQLKKSK-EHEKLMEGELEALRQEFKKKDKT 505
Q ++ + + +E T ++E + +L+ K + + L +L+ L+Q+++ + +
Sbjct: 585 NQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEK 644
Query: 506 LKENSRKLEEENENLRAELQCCSTQLESSLNKYNTSQQVIQDLN----KEIALQKESLMS 561
L+E K E+E E L + K Q I+++N +++ +++ L S
Sbjct: 645 LRE---KCEQEKETLLKD-------------KEIIFQAHIEEMNEKTLEKLDVKQTELES 688
Query: 562 LQAQLDKALQKEKHYL--QTTITKEAYDALSRKSAACQDDLTQALEKLNHVTSETKSLQQ 619
L ++L + L K +H L + ++ K+ D + ++ A D+ +K +H +++
Sbjct: 689 LSSELSEVL-KARHKLEEELSVLKDQTDKMKQELEAKMDE-----QKNHHQQQVDSIIKE 742
Query: 620 SLTQTQEKKAQLEEEIIAYEERMKKLNTELRKLRGFHQESELEVHAFDKKLEEMSCQVLQ 679
Q + L+++I E +K+ + L++ + + E ++ + +L++ S ++
Sbjct: 743 HEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDV 802
Query: 680 WQKQHQNDLKMLAAKEEQLREFQEEMAALKENLLEDDKEPCCLPQW-----SVPKDTC-R 733
+Q +A EQ + ++E++A L++ LL+ + E L + + KD C
Sbjct: 803 FQSYQ-------SATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTE 855
Query: 734 LYRGNDQIMTNLEQWAKQQKVANEKL-------------GNQLREQVKYIAKLSGEKD-- 778
L Q+ ++Q KQ +K+ GN+ +EQ K I EK+
Sbjct: 856 LDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILV---EKENM 912
Query: 779 ----REPTRASSPNTTRPSSPSHSHLHSVMVHLQQENKKLKKEIEEKKMKAE 826
RE + T+ S +H + + + K +K++E+ K KA+
Sbjct: 913 ILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAK 964
Score = 118 bits (295), Expect = 3e-26
Identities = 196/940 (20%), Positives = 402/940 (42%), Gaps = 169/940 (17%)
Query: 8 TGEKLHLAQEQLALAGDKIASLERSLNLYRDKYQSSLSNIELLECQVKMLQGELGGIMGQ 67
T EK L QEQL +++ LE+ +L+ + ++ + + ++ L+ + G ++ +
Sbjct: 313 TSEKEAL-QEQL---DERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAE 368
Query: 68 EPENKGDHSKVRIYTSPCMIQEHQETQKRLSEVWQKVSQQDDLIQELRNKLACSNALVLE 127
T M + + ++ ++++ ++ Q +ELR + S E
Sbjct: 369 --------------TKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFE 414
Query: 128 R-EKALIKLQADFASCTATHRYPPSSSEECEDIKKILK-HLQEQ-KDSQCLHVEEYQNLV 184
EKAL S++++ E+ ++ LK + EQ K + EE +L
Sbjct: 415 ELEKAL------------------STAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQ 456
Query: 185 KDL-RVELEAVSEQKRNIMKDMMKLELDLHGLREETSAHIERKDKDITILQCRLQELQLE 243
++L RV+ E V K++ + + KL+ LH + RK++++T +LQ + E
Sbjct: 457 QELSRVKQEVVDVMKKSSEEQIAKLQ-KLH------EKELARKEQELTK---KLQTRERE 506
Query: 244 FTETQKLTLKKD-----KFLQEKDEM----LQELEKK----LTQVQNSLLKKEKELEKQQ 290
F E K+ L+K K QEK++ L+ELE + LT+ +N L ++E E +
Sbjct: 507 FQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAETYR 566
Query: 291 CMATELEMTVKEAKQDKSKEAECKALQAEVQKLKNSLE-------EAKQQERLAAQQAAQ 343
ELE +++++ Q+ +++ A+ E +K K++ E + E L QQ A
Sbjct: 567 TRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDAL 626
Query: 344 CKEEAALAGCHLEDTQRKLQKGLLLDKQKADTIQELQRELQMLQKESSMAEKEQTSNRKR 403
E+ + + KL++ +K+ +E+ + + + EK +
Sbjct: 627 WTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTE- 685
Query: 404 VEELSLELSEALRKLENSDKEKRQLQKTVAEQDMKMNDMLDRIKHQHREQ-GSIKCKLEE 462
+E LS ELSE L+ ++E L+ + ++ +D K+ H++Q SI + E
Sbjct: 686 LESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEV 745
Query: 463 DLQEATKLLEDKREQL----KKSKEHEKLMEGELEALRQEFKKKDKTLKENSRKL----- 513
+Q K L+D+ QL K+ +H K + +E L + K+ + L++ S KL
Sbjct: 746 SIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQS 805
Query: 514 ------------EEENENLR-----------------AELQCCSTQLESSLNKYNTS-QQ 543
EE+ L+ AE++ + + L+ + Q
Sbjct: 806 YQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQD 865
Query: 544 VIQDLNKEIALQKESLMSL----QAQLDKALQKEKHYLQTTITKE------------AYD 587
++Q L K+ + ++ + SL +++L+ ++++ Q + KE +
Sbjct: 866 LMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIE 925
Query: 588 ALSRKSAACQDDLTQALE-----------KLNHVTSETKSLQQSLT-----QTQEKKAQL 631
L++K +A +D + E K+ V + K +Q++L Q + K +L
Sbjct: 926 ILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKEL 985
Query: 632 EEEIIAYEERMKKLNTELRKLRGFHQESELEVHAFDKKLE-EMSCQVLQWQKQHQNDLK- 689
E + ++ K+ N ++ ++ Q + + +LE Q+ + H+ +L
Sbjct: 986 ENTALELSQKEKQFNAKMLEMA---QANSAGISDAVSRLETNQKEQIESLTEVHRRELND 1042
Query: 690 MLAAKEEQLREFQEEMAALKENLLEDDKEPCCLPQWSVPKDTCRLYRGNDQIMTNLEQWA 749
+++ E++L + EE+ + E L++ ++ + + C N +I W
Sbjct: 1043 VISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEIT-----WL 1097
Query: 750 KQQKVANEKLGNQLREQVKYIAKLSGEKDREPTRASSPNTTRPSSPSHSHLHSVMVHLQ- 808
K++ V + N+L+EQ+K + ++ T+ +HL + V L
Sbjct: 1098 KEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLK------------AHLEKLEVDLNK 1145
Query: 809 --QENKKLKKEIEEKKMKAENTRLCTKALGPSRTESTQRE 846
+EN L++++ E KM AE + L S+ ++T E
Sbjct: 1146 SLKENTFLQEQLVELKMLAEEDKRKVSEL-TSKLKTTDEE 1184
Score = 108 bits (269), Expect = 3e-23
Identities = 170/772 (22%), Positives = 330/772 (42%), Gaps = 91/772 (11%)
Query: 12 LHLAQEQLALAGDKIASLERS----LNLYRDKYQSSLSNI-----ELLECQVKMLQGELG 62
L +AQ A D ++ LE + + + ++ L+++ + L Q + LQ E+
Sbjct: 1004 LEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQ-EIH 1062
Query: 63 GIMGQEPENKGDHSKVRIYTSPCMIQEHQETQKRLSEVWQKVSQQD----DLIQELRNKL 118
I QE E + K +I C E +E K ++ + ++ +QD +L ++L+ K
Sbjct: 1063 EIQLQEKEQEVAELKQKILLFGC---EKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKS 1119
Query: 119 ACSNALVLEREKA---LIKLQADFASCTATHRYPPSSSEEC-----EDIKKILKHLQEQK 170
A N+L + K L KL+ D + + E ED +K+ + + K
Sbjct: 1120 AHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLK 1179
Query: 171 DSQCLHVEEYQNLVKDLRVELEAVSEQKRNIMKDMMKLELDLHGLREETSAHIERKDKD- 229
+ EE+Q+L +++ ++ K +L + L ++T A +E K +
Sbjct: 1180 TTD----EEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNEL 1235
Query: 230 ITILQCRLQELQLEFTETQKLTLKKDKFLQEKDEMLQELE---KKLTQVQNSL------- 279
I I + + + Q T K + L K + ELE ++LT+ QN+L
Sbjct: 1236 INISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQA 1295
Query: 280 ---LKKEKELEKQQCMATELEMTVKEAKQDKSKEAECKALQAE--VQKLKNSLEEAKQQE 334
L++++ K E +T KEA Q + + A + E + +LK L E
Sbjct: 1296 THQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAV 1355
Query: 335 RLAAQQAAQCKEEAALAGCHLEDTQRKLQKGLLLDKQKADTIQ----------ELQRELQ 384
L ++ + K E + L D +LQ + L +++A EL ++Q
Sbjct: 1356 TLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQ 1415
Query: 385 MLQKESSMAEKEQTSNRKRVEELSLELSEALRKLE-------NSDKEKR-QLQ---KTVA 433
L + KE+ S ++V++ S + SE +K + N+ KE + QL+ K
Sbjct: 1416 DLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAY 1475
Query: 434 EQDMKMNDMLDRIKHQHREQGSIKCKLEEDLQEATKLLEDKREQLKKSKEHEKLMEGELE 493
E+D ++N + + + Q++ +K ++E+D + K + +LK +E +
Sbjct: 1476 EKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHIT 1535
Query: 494 ALRQEFKKKDKTLKENSRKLEEENENLRAELQCCSTQLESSLNKYNTSQQVIQDLNKEIA 553
E + ++ LK +++ + E++ L +LQ E N+ +++ I L ++
Sbjct: 1536 QKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVY 1595
Query: 554 LQKESLMSLQAQLDKALQKEKHYLQTTITKEAYDALSRKSAACQDDLTQALEKLNHVTSE 613
K L + + +L+ K + K D L +SAA L + K +
Sbjct: 1596 SMKAELETKKKELEHVNLSVKS--KEEELKALEDRLESESAA---KLAELKRKAEQKIAA 1650
Query: 614 TKSLQQSLTQTQEKKAQLEEEIIAYEERMKKLNTELRKLRGFHQESELEVHAFDKKLEEM 673
K +Q L+Q +EK+ Q ++ E + +LNT+L QE E EVH ++KL+ +
Sbjct: 1651 IK--KQLLSQMEEKEEQYKK---GTESHLSELNTKL-------QEREREVHILEEKLKSV 1698
Query: 674 SCQVLQWQKQHQNDLKMLAAKEEQ--------LREFQEEMAALKENLLEDDK 717
+ ++ + A E++ + ++E+++ L+ NL E +K
Sbjct: 1699 ESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEK 1750
Score = 107 bits (267), Expect = 5e-23
Identities = 178/884 (20%), Positives = 373/884 (42%), Gaps = 168/884 (19%)
Query: 25 KIASLERSLNLYRDKYQSSLSNIELLECQVKMLQGELGGIMGQEP---ENKGDHSKVRIY 81
++ L N +Q + +E E Q+K ++ ++ ++ ++ + G+ +
Sbjct: 1277 QLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASE 1336
Query: 82 TSPCMIQEHQETQKRLS--------------EVWQKVSQQDDLIQELRNKLACSNALVLE 127
C+ Q +E + ++ E+ Q DL +L+N ++ S E
Sbjct: 1337 KESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLS-----E 1391
Query: 128 REKALIKL--QADFASCTA-------THRYPPSSSEECEDIKKI---LKHLQEQKDSQCL 175
+E A+ L Q D C + + S E+ ++++ E K
Sbjct: 1392 KEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQS 1451
Query: 176 HVEEYQNLVKDLRVELEAVSEQ--KRNIMKDMMKLELD--------LHGLREETSAHIER 225
++QN VK+L+++LE S++ +++ +++K ELD L G E+ + +E+
Sbjct: 1452 RFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEK 1511
Query: 226 KDKDI-TILQ---CRLQELQLEFT----------------------ETQKLTLKKDKFLQ 259
K+ ++ T L+ R+ EL+ T E ++L K F +
Sbjct: 1512 KESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQE 1571
Query: 260 ---EKDEMLQELEKKLTQVQNSLLKKEKELEKQQCMATELEMTVKEAKQDKSKEAECKAL 316
EKD ++E E+K+ ++N + + ELE ++ + ++VK SKE E KAL
Sbjct: 1572 LGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVK------SKEEELKAL 1625
Query: 317 QAEVQKLKNSLEEAKQQERLAAQQAAQCKEEAALAGCHLEDTQRKLQKGLLLDKQKADT- 375
+ ++ S + + +R A Q+ A K++ +E+ + + +KG + +T
Sbjct: 1626 EDRLES--ESAAKLAELKRKAEQKIAAIKKQLL---SQMEEKEEQYKKGTESHLSELNTK 1680
Query: 376 IQELQRELQMLQKESSMAEKEQTSN-----------------------------RKRVEE 406
+QE +RE+ +L+++ E Q+ +++
Sbjct: 1681 LQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISV 1740
Query: 407 LSLELSEALRKLENSDKEKRQLQKTVAEQDMKMNDMLDRIKH----QHREQGSIKCKLEE 462
L L+E + L+ +EK + + E + + L +++H QH +Q I L+E
Sbjct: 1741 LQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIG-HLQE 1799
Query: 463 DLQEATKLLE------DKREQLKKSKEHEKLMEGELEALRQEFKKKDKTLKENSRKLEEE 516
+L+E K ++E K + + ++ +E + +++ ++K+ T + +K++E
Sbjct: 1800 ELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKEL 1859
Query: 517 NENLRAELQCCSTQLESSLNKYNTSQQVIQ--------DLNKEIALQKESLMSLQAQLDK 568
+ L + + ++E +KY Q + Q +L +E +K +Q +L
Sbjct: 1860 DSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLS 1919
Query: 569 ALQKEKHYLQTTIT--KEAYDALSRKSAACQDDLTQALEKLNHVTSETKSLQQSLTQTQE 626
++ + + L+ + + L ++ Q DL + L K + E + L++ Q +E
Sbjct: 1920 NMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDL-RMLRKEHQ--QELEILKKEYDQERE 1976
Query: 627 KKAQLEEEII------AYEERMKKLNTELRKLRGFHQESELEVHAFDKKLEEMSCQVLQW 680
+K + E+E + ++ M++ NT+L + QE E+ + K +E+ ++L+
Sbjct: 1977 EKIKQEQEDLELKHNSTLKQLMREFNTQLAQKE---QELEMTIKETINKAQEVEAELLES 2033
Query: 681 QKQHQN-----------DLKMLAAKEEQLREFQEEMAALKENLLEDDKEPCCLPQWSVPK 729
++ N DLK A + E++ + +EE K L+ E L + K
Sbjct: 2034 HQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLEE--LQKKYQQK 2091
Query: 730 DTCRLYRGND-----QIMTNLEQWAKQQKVANEKLGNQ-LREQV 767
GND ++ T L Q K +++ KL Q REQ+
Sbjct: 2092 LEQEENPGNDNVTIMELQTQLAQ--KTTLISDSKLKEQEFREQI 2133
Score = 78.6 bits (192), Expect = 2e-14
Identities = 124/604 (20%), Positives = 266/604 (44%), Gaps = 57/604 (9%)
Query: 65 MGQEPENKGDHSKVRIYTSP----CMIQEHQETQKRLSEVWQKVSQQDDLIQELRNKLAC 120
+G+E +N+ ++ +I T M E + +K L V V +++ ++ L ++L
Sbjct: 1572 LGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLES 1631
Query: 121 SNALVLEREKALIKLQADFASCTATHRYPPSSSEECEDIKKILK-HLQE-----QKDSQC 174
+A L A +K +A+ + E+ E KK + HL E Q+ +
Sbjct: 1632 ESAAKL----AELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQERERE 1687
Query: 175 LHV-EEYQNLVKDLRVELEAVSEQKRNIMKDMMKLELDLHGLREETSAHIERKDKDITIL 233
+H+ EE V+ + E V +N+ + E D G ++T ++ I++L
Sbjct: 1688 VHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTY------EEKISVL 1741
Query: 234 QCRLQELQLEFTETQKLTLKKDKFLQEKDEMLQELEKKLTQVQNSLLKKEKELEKQQCMA 293
Q L E + Q++ +K++ + EM + +++L +++++ K+ ++ +
Sbjct: 1742 QRNLTEKEKLL---QRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQ 1798
Query: 294 TELEMTVKE----AKQDKSKEAECKALQAEVQKLKNSLEEAK---QQERLAAQQAAQCKE 346
ELE K+ Q KE +QA+ Q L+N ++ + Q++ L Q Q +
Sbjct: 1799 EELEEKNKKYSLIVAQHVEKEGGKNNIQAK-QNLENVFDDVQKTLQEKELTCQILEQKIK 1857
Query: 347 EAALAGCHLEDTQRKLQKGLLLDKQKADTIQELQ---RELQMLQKESSMAEKEQTSNRKR 403
E ++ R + L +K +Q++ + ++L++ + K K
Sbjct: 1858 ELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKL 1917
Query: 404 VEELSLELSEALRKLENSDKEKRQLQKTVA--EQDMKMNDMLDRIKHQHREQGSIKCKLE 461
+ + + ++ KL +++EK++L K + ++D++M ++ +H+++ I K E
Sbjct: 1918 LSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRM------LRKEHQQELEI-LKKE 1970
Query: 462 EDLQEATKLLEDKRE-QLKKSKEHEKLMEGELEALRQEFKKKDKTLKENSRKLEEENENL 520
D + K+ +++ + +LK + ++LM L Q+ ++ + T+KE K +E L
Sbjct: 1971 YDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEVEAEL 2030
Query: 521 RAELQCCSTQLESSLNKYNTSQQVIQDLNKEIALQKESLMSLQAQLDKALQKEKHYLQTT 580
Q + QL + + + + +EI +E M+ + + LQ + LQ
Sbjct: 2031 LESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKV---RDLQTQLEELQ-- 2085
Query: 581 ITKEAYDALSRKSAACQDDLTQALEKLNHVTSETKSLQQSLTQTQEKKAQLEEEIIAYEE 640
K+ L ++ D++T +E + +T + S + QE E+I E+
Sbjct: 2086 --KKYQQKLEQEENPGNDNVT-IMELQTQLAQKTTLISDSKLKEQE----FREQIHNLED 2138
Query: 641 RMKK 644
R+KK
Sbjct: 2139 RLKK 2142
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 134 bits (338), Expect = 3e-31
Identities = 194/893 (21%), Positives = 387/893 (43%), Gaps = 96/893 (10%)
Query: 10 EKLHLAQEQLALAGDKIASLERSLNLYRDKYQSSLSNIELLECQVK-MLQGELGGIMGQE 68
EK +E+L D L+ + + ++ + L+ QV+ + G+L QE
Sbjct: 1196 EKERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQE 1255
Query: 69 PENKGDHSKVRIYTSPCMIQEHQETQKRLSEVWQKVSQQDDLIQELRNKLACSNALVLER 128
+ + ++ + + L W S+ +Q +A A + E
Sbjct: 1256 SCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQG-GTSVAQIKAQLKEI 1314
Query: 129 EKALIKLQADFASCTATHRYPPSSSEECEDIKKILKHLQEQKDSQCLHVEEYQNLVKDLR 188
E ++L+ +S T+ +++ E++ + LQEQ + Q L +E + + +
Sbjct: 1315 EAEKVELELKVSSTTS------ELTKKSEEVFQ----LQEQINKQGLEIESLKTVSHEAE 1364
Query: 189 VELEAVSEQKRNIMKDMMKLE--LDLHGLREETSAHIERKDKDITILQCRLQELQLEFTE 246
V E++ ++ + + LE +L +E I +K++D++ L +L E + T+
Sbjct: 1365 VHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTK 1424
Query: 247 TQKLTLKKDKFLQ-----------EKDEMLQELEKKLTQVQNSLLKKEKELEKQQCMATE 295
Q ++++ ++ E DE +++L+ +L +++ + +E +Q + +
Sbjct: 1425 IQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRK 1484
Query: 296 LEMTV---KEA-KQDKSKEAECKALQAEVQKLKNSLEEAKQQERLAAQQAAQCKEEAALA 351
L+ + KEA K++KS + E + +++L SL + + +Q +AQ KE+ +
Sbjct: 1485 LQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVE------SQVSAQNKEKDTVL 1538
Query: 352 G--CHLEDTQRKL----QKGLLLDKQKADTIQELQRELQMLQKESSMAEKE--------- 396
G L++ + KL + LL ++ + + + L+ L+ L ++ KE
Sbjct: 1539 GRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKI 1598
Query: 397 --QTSNRKRVEELSLELSEALRKLENSDKEKRQLQKTVAEQDMKMNDMLDRIKHQHREQG 454
T +++ +EL E L+ EN E ++Q V + ++ ++ R
Sbjct: 1599 AESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKL----RSTE 1654
Query: 455 SIKCKLEEDLQEATKLLEDKREQLKK---SKEHEKL-MEGELEALRQEFKKKDKTLKE-- 508
+ K + E+ LQEA + +E+ +E+++K SK+ + L +E E + LR E T KE
Sbjct: 1655 ANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECM 1714
Query: 509 -----NSRKLEEENENLRAELQCCSTQLESSLNKYNTSQQVIQDLNKEIALQKESLMSLQ 563
++ ++EE E ++ E + S + +S +++ ++ + +QDL +I E +S Q
Sbjct: 1715 ETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQI----EGNVSKQ 1770
Query: 564 AQLDKALQKEKHYLQTTITKEAYDALSRKSAACQDDLTQALEKLNHVTSETKSLQQSLTQ 623
A L+ EKH QT +T+E ++ ++ QD L+ + SE+ +S
Sbjct: 1771 ANLEAT---EKHDNQTNVTEEGTQSIPGETEE-QDSLSMSTRP---TCSESVPSAKSANP 1823
Query: 624 TQEKKAQLEEEIIAYEERMKKLNTELRKLRGFHQESELEVHAFDKKLEEMSCQVLQWQKQ 683
K +EI Y +++ +L + L +E + + F + LE +L
Sbjct: 1824 AVSKDFSSHDEINNYLQQIDQLKERIAGL----EEEKQKNKEFSQTLENEKNTLLSQIST 1879
Query: 684 HQNDLKMLAAK-------EEQLREFQEEMAALKENLLE--DDKEPCCLPQWSVPKDTCRL 734
+LKML + +Q++E + LKE E DD E + Q + +
Sbjct: 1880 KDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGN 1939
Query: 735 YRGN--DQIMTN--LEQWAKQQKVANEKLGNQLREQVKYIAKLSGEKDREPTRASSPNTT 790
Y + D + N LE K K +L + ++ VK K+ E +E
Sbjct: 1940 YCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQK 1999
Query: 791 RPSSPSHS-HLHSVMVHLQQENKKLKKEIEEKKMKAENTRLCTKALGPSRTES 842
P + SH+ L ++ QQE K+L+K+ + K KAL +TES
Sbjct: 2000 EPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTES 2052
Score = 115 bits (287), Expect = 2e-25
Identities = 156/752 (20%), Positives = 327/752 (43%), Gaps = 97/752 (12%)
Query: 6 ENTGEKLHLAQEQLALAGDKIASLERSLNLYRDKYQSSLSNIELLECQVKMLQGELGGIM 65
E T H +Q +LA ++ SL+ L + LSN L +C K +G L GI+
Sbjct: 2294 EETRHLYHSSQNELAKLESELKSLKDQL--------TDLSN-SLEKC--KEQKGNLEGII 2342
Query: 66 GQEPENKGDHSKVRIYTSPCMIQEHQETQKRLSE--------VWQKVSQQDDLIQ----E 113
Q+ E +SK +Q +E RL E + +S +++ IQ E
Sbjct: 2343 RQQ-EADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAE 2401
Query: 114 LRNK-----LACSNALVLEREKALIKLQADFASCTATHRYPPSSSEECEDIKKILKHLQE 168
LR + N L E E+ ++ + + + T++ + + LK +++
Sbjct: 2402 LRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQ-----------LMETLKTIKK 2450
Query: 169 QKDSQCLHVEEYQNLVKDLRVELEAVSEQKRNIMKDMMKLELDLHGLREETSAHIERKDK 228
+ Q ++ + + L+ + + + + + + + + L+ L +E +A + +
Sbjct: 2451 ENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKE 2510
Query: 229 DITILQCRLQELQLEFTETQKLTLKKDKFLQEKDEMLQELEKKLTQVQNSLLKKEKELEK 288
+I L+ + +L +E KL + ++ ++ ++++ + + Q+ L++ KELE
Sbjct: 2511 EIRGLRSHMDDLN---SENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELEN 2567
Query: 289 QQCMATELEMTVKEAKQDKSKEAECKALQAEVQKLKNSLEEAKQQERLAAQQAAQCKEEA 348
+ E +EA +D + ALQ E Q L +E K +Q +EE
Sbjct: 2568 KYAKLEEKLKESEEANEDLRRSFN--ALQEEKQDLSKEIESLKVSISQLTRQVTALQEEG 2625
Query: 349 ALAGCHLE----------------DTQRKL----QKGLLLDKQKADTIQE----LQRELQ 384
L H + +Q+++ ++ + + K+ A + E L++EL+
Sbjct: 2626 TLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELK 2685
Query: 385 MLQKESSMAEKEQTSNRKRVEELSLELSEALRKLENSDKEKRQLQKTVAEQDMKMNDMLD 444
L ++ + E + +RV EL+ +L E +KL KE + L + M+ + +
Sbjct: 2686 HLHHDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQN 2745
Query: 445 RIKHQHREQGSIKCKLEEDLQEATKLLEDKREQLKKSKEHEKLMEGELEALRQEFKKKDK 504
H + E +K K + L+E +L E + L+ E +AL E
Sbjct: 2746 SRDHANEELDELKRKYDASLKELAQLKE------------QGLLNRERDALLSETAFSMN 2793
Query: 505 TLKENSRK-LEEENENLRA---ELQCCSTQLESSLNKYNTSQQVIQDLNKEIALQKESLM 560
+ +ENS LE+ N+ L + +L S+QLE S N+ + + + L E ++ L
Sbjct: 2794 STEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNE----RDHLW 2849
Query: 561 SLQAQLDKALQ-KEKHYLQTTITKEAYDALSRKSAACQDDLTQALEKLNHVTSETKSLQQ 619
+ + K+ + K++ Q + + +L + ++ Q+D + L++L ++ + + Q
Sbjct: 2850 NELEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQ 2909
Query: 620 SLTQTQEKKAQLEEEIIAYEERMKKLNTELRKLRGFHQESELEVHAFDKKLEEMSCQVLQ 679
+T+ KAQL+E Y+++ K +LR + + E+H ++E+ S ++ +
Sbjct: 2910 EITELHPLKAQLQE----YQDKTKAFQIMQEELRQENLSWQHELHQL--RMEKSSWEIHE 2963
Query: 680 WQKQHQNDLKMLAAKEEQLREFQEEMAALKEN 711
++ + L ++ K++QL Q + L+ +
Sbjct: 2964 -RRMKEQYLMAISDKDQQLSHLQNLIRELRSS 2994
Score = 99.4 bits (246), Expect = 1e-20
Identities = 148/792 (18%), Positives = 338/792 (42%), Gaps = 89/792 (11%)
Query: 87 IQEHQETQKRLSEVWQKVSQQDDLIQELRNKLACSNALVLEREKALIKLQADFASCTATH 146
++E ++ K S+ + ++++ L+ ++ K L E K + Q +
Sbjct: 1852 LEEEKQKNKEFSQTLE--NEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVT 1909
Query: 147 RYPPSSSEECEDIK-KILKHLQEQKDSQCLHVEEYQNLVKDLRVELEAVSEQKRNIMKDM 205
+ ++ EE +D++ +++ L E S + Y V D +++ E + + +N+ K +
Sbjct: 1910 KLKETAEEEKDDLEERLMNQLAELNGS----IGNYCQDVTDAQIKNELLESEMKNLKKCV 1965
Query: 206 MKLELDLHGL-REETSAHIERKDKDITILQCRLQELQLEFTETQKLTLKKDKFLQEKDEM 264
+LE + L +E+T E + + + +Q +E + + + L+EK +
Sbjct: 1966 SELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKE-----PGNKSHAKELQELLKEKQQE 2020
Query: 265 LQELEKKLTQVQNSLLKKEKELEKQQCMATELEMTVKEAKQDKSKEAEC-KALQAEVQKL 323
+++L+K + Q + E+ ++ + + TE + ++ K++ ++ E K QAE+
Sbjct: 2021 VKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASF 2080
Query: 324 KNSLEEAKQQ------ERLAAQQAAQCKEEAALAGCHL--EDTQRKLQKGLLLDKQKADT 375
K L++ + + + L ++ Q +E+ + ED +R+L++ +++
Sbjct: 2081 KVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQA---EEKHLKE 2137
Query: 376 IQELQRELQMLQKESSMAEKEQTSNRKRVEELSLELSEALRKLENSDKEKRQLQKTVAEQ 435
+ +Q +L L++E E+ + + + E+ + L+++ + K+++
Sbjct: 2138 KKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSL 2197
Query: 436 DMKMNDMLDRIKHQHREQGSIKCKLEEDL---QEATKLLEDKREQLKKSKEHEKLMEGEL 492
+ ++D K R+ EE++ ++ +L+D+ Q+ E K+ L
Sbjct: 2198 QDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRL 2257
Query: 493 EALRQEFKKKDKTLKENSRKLEEENENLRAELQCCSTQLESSLNKYNTSQQVIQDLNKEI 552
E +Q ++ K +T + +K+ + L+ E + +QLE + + Y++SQ + L E+
Sbjct: 2258 EHDKQIWESKAQTEVQLQQKV---CDTLQGENKELLSQLEETRHLYHSSQNELAKLESEL 2314
Query: 553 ALQKESLMSLQAQLDKALQKEKHYLQTTI---------TKEAYDALSRKSAACQDDLTQA 603
K+ L L L+K +++K L+ I +K +Y+ L A ++ ++
Sbjct: 2315 KSLKDQLTDLSNSLEKC-KEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRL 2373
Query: 604 LEKLN--------------------------HVTSETKSLQQSLTQTQEKKAQLEEEIIA 637
E++N E K L+ L+Q +E+ LEEE
Sbjct: 2374 HEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKK 2433
Query: 638 YEERMKKLNTELRKLRGFHQESELEVHAFDKKLEEMSCQ----VLQWQKQHQNDLKMLAA 693
++ +L L+ ++ + + + ++ +F K + + V +Q+ + L ++
Sbjct: 2434 AVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILE 2493
Query: 694 KEEQLREFQEEMAALKENL--LEDDKEPCCLPQWSVPKDTCRLYRGNDQIMTNLEQWAKQ 751
K++ ++E E LKE + L + + + + +Q++T + Q
Sbjct: 2494 KDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKD---SQ 2550
Query: 752 QKVANEKLGNQLREQVKYIAKLSGEKDREPTRASSPNTTRPSSPSHSHLHSVMVHLQQEN 811
QK QL E +L K+ E A + S ++ L LQ+E
Sbjct: 2551 QK--------QLLE-----VQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEEK 2597
Query: 812 KKLKKEIEEKKM 823
+ L KEIE K+
Sbjct: 2598 QDLSKEIESLKV 2609
Score = 97.8 bits (242), Expect = 4e-20
Identities = 196/942 (20%), Positives = 351/942 (37%), Gaps = 197/942 (20%)
Query: 63 GIMGQEPENKGDHSKVRIYTSPCMIQEHQETQKRLSEVWQKVSQQDDLIQELRNKLACSN 122
G+ + + GD S + P + Q HQ+ +RL ++ QE+ K
Sbjct: 658 GVELKSTKQDGDKSLSAV---PDIGQCHQDELERLKSQILELELNFHKAQEIYEKNLDEK 714
Query: 123 ALVLEREKALI---KLQADFASCTATHRYPPSSSEECEDIKKILKHLQEQKDSQCLHVEE 179
A + LI K AD S T + SEE + + +K L V E
Sbjct: 715 AKEISNLNQLIEEFKKNADNNSSAFT-----ALSEERDQLLSQVKELSM--------VTE 761
Query: 180 YQNLVKDLRVELEAVSEQKRNIMKDMMKLELDLHGLREETSAHIERKDKDITILQCRLQE 239
+ VK L + L Q+R + + L S + KD I +LQ L +
Sbjct: 762 LRAQVKQLEMNLAEAERQRRLDYESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELDD 821
Query: 240 LQLEFTETQKLTLKKDKFLQEKD-------EMLQELEKKLTQVQNSLLKKEKELEKQQCM 292
+QL+F+E L LQ K+ E ++ + K+ ++ +L +KE E+ K +
Sbjct: 822 VQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEELSQALSQKELEITKMDQL 881
Query: 293 ATE-------LEMTVKEAKQDKSK------------EAECKALQAEVQKLKNSL------ 327
E L+ T++E Q ++ E +L E++ LK L
Sbjct: 882 LLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRA 941
Query: 328 EEAKQQ-----------------ERLAAQQAA--QCKEEAALAGCHLEDTQRKLQKGLLL 368
EEAK++ E A Q + + + E L E +RKLQ L+
Sbjct: 942 EEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALIN 1001
Query: 369 DKQKADTIQELQRELQMLQKES---------------------SMAEKEQTSNRKRVE-- 405
K+ + L+ EL L+ ES +EK TS + +E
Sbjct: 1002 RKELLQRVSRLEEELANLKDESKKEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIY 1061
Query: 406 ------ELSLELSEALRKLENSDKEKRQLQKTVAEQDMKMND---MLDRIKHQHREQGSI 456
E +EL + LE + Q Q V + + + D +D ++ + E +I
Sbjct: 1062 LKQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAI 1121
Query: 457 KCKL---------------------------------EEDLQEATKLLEDKREQ------ 477
KL + +L+E LE ++EQ
Sbjct: 1122 IQKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQ 1181
Query: 478 ---------LKKSKEHEKLMEGELEALRQEFKKKDKTLKENSRKLEEENENLRAELQCCS 528
LKK++E E+ + EL+ + ++ + + E S+ ENEN+ +L+
Sbjct: 1182 EALTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSK----ENENIGDQLRQLQ 1237
Query: 529 TQLESSLNKYNTSQQVIQDLNKEIALQKESLMS---LQAQLDKALQKEKHYLQTTITKEA 585
Q+ S++ S Q+ES S L+ L KA E+H+ Q +
Sbjct: 1238 IQVRESIDGKLPSTD-----------QQESCSSTPGLEEPLFKA--TEQHHTQPVLESNL 1284
Query: 586 ---YDALSRKSAACQ--DDLTQALEKLNHVTSETKSLQQSLTQTQEKKAQLEEEIIAYEE 640
+ + S ++A Q + Q +L + +E L+ ++ T + + EE+ +E
Sbjct: 1285 CPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQE 1344
Query: 641 RMKKLNTELRKLRGFHQESELEVHAFDKKLEEMSCQVLQWQKQHQNDLKMLAAKEEQLRE 700
++ K E+ L+ E+E+ + +KLE Q+ A E LRE
Sbjct: 1345 QINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQI---------------AGLEHLRE 1389
Query: 701 FQEEMAALKENLLEDDKEPCCLPQWSVPKDTCRLYRGNDQIMTNLEQWAKQQKVANEKLG 760
Q ++ L++ + + +++ L K+ +I T + + K + +L
Sbjct: 1390 LQPKLDELQKLISKKEEDVSYLSGQLSEKEAAL-----TKIQTEIIEQEDLIKALHTQLE 1444
Query: 761 NQLREQVKYIAKLSGEK-DREPTRASSPNTTRPSSPSHSHLHSVMVHLQQENKKLKKEIE 819
Q +E + I +L E + + +R L + ++ ++ K+ K E
Sbjct: 1445 MQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQE 1504
Query: 820 EKKMKAENTRLCTKALGPSRTE-STQREKVCGTLGWKGLPQD 860
E + TK+L ++ S Q ++ LG L Q+
Sbjct: 1505 ELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQE 1546
Score = 81.3 bits (199), Expect = 4e-15
Identities = 130/644 (20%), Positives = 274/644 (42%), Gaps = 86/644 (13%)
Query: 70 ENKGDHSKVRIYTSPCMIQEHQETQKRLSEVWQKVSQQDDLIQELRNKLACSNALVLERE 129
E GD + +P + HQE+ + Q ++++ +LA + LV+E
Sbjct: 15 ELSGDDDTDQNMRAPLDPELHQESDMEFNNTTQ---------EDVQERLAYAEQLVVEL- 64
Query: 130 KALIKLQADFASCTATHRYPPSSSEECEDIKKILKHLQEQKDSQCLHVEEYQ----NLVK 185
K +I+ Q D IKK+ H + + S ++EE + ++
Sbjct: 65 KDIIR-QKDVQLQQKDEALQEERKAADNKIKKLKLHAKAKLTSLNKYIEEMKAQGGTVLP 123
Query: 186 DLRVELEAVSEQKRNIMKDMMKLELDLHGLREETSAHIERKDKDITILQCRLQELQLE-- 243
E +S+ ++ ++ M++E H L+E K++ I+ LQ +L + Q E
Sbjct: 124 TEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQE--------KEELISTLQAQLTQAQAEQP 175
Query: 244 ---FTETQKLTLKKDKFLQEKDEMLQELEKKLTQVQNSLLKKEKELEKQQCMATELEMTV 300
TE ++ + K + LQEK+E + L+ +L+Q Q ++ EK T++ +
Sbjct: 176 AQSSTEMEEFVMMKQQ-LQEKEEFISTLQAQLSQTQAEQAAQQVVREKDARFETQVRLHE 234
Query: 301 KEAKQDKSKEAECKALQAEVQKLKNSLEEAKQQERLAAQQAAQCKEEAALAGCHLEDTQR 360
E Q ++ +Q +++ L+ LEE ++ AQ ++E A
Sbjct: 235 DELLQLVTQADVETEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAE-------- 286
Query: 361 KLQKGLLLDKQKADTIQELQRELQMLQKESSMAEKEQTSNRKRVEELSLELSEALRKLEN 420
Q+ +L +Q +Q+++ E L+ + E E+ ++ +E++ LE++E N
Sbjct: 287 --QRNQILSQQ----LQQMEAEHNTLR---NTVETEREESKILLEKMELEVAERKLSFHN 337
Query: 421 SDKEKRQLQKTVAEQDMKMNDMLDR---IKHQHREQGSIKC-------KLEEDLQEATKL 470
+E L + + ++ R ++ +H+ + K K ++LQ A
Sbjct: 338 LQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSACDA 397
Query: 471 LEDKREQLKKSKEHEKLMEGE-LEALRQEFKKKDKTLKENSRKLEEENENLRAELQCCST 529
L+D+ +L + K + + + ++ L + ++K K + + +L LQ T
Sbjct: 398 LKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRL---------PLQQHET 448
Query: 530 QLESSL-NKYNTSQQVIQDLNKEIALQKESLMSLQAQLDKALQKEKHYLQTTITKEAYDA 588
++S + YN Q A+ +E++ SLQ ++ + ++ L ++I E A
Sbjct: 449 ASQTSFPDVYNEGTQ---------AVTEENIASLQKRVVELENEKGALLLSSIELEELKA 499
Query: 589 LSRKSAACQDDLTQALEKLNHVTSETKSLQQSLTQTQEKKAQLEEEI------IAYEERM 642
+ K ++ Q L +A + E + S+ K++ EE + ++
Sbjct: 500 ENEKLSS-QITLLEAQNRTGEADREVSEI--SIVDIANKRSSSAEESGQDVLENTFSQKH 556
Query: 643 KKLNTELRKLRGFHQE-SELEVHAFDKKLEEMSCQVLQWQKQHQ 685
K+L+ L +++ +E + L++ K+ EE +VL ++ Q
Sbjct: 557 KELSVLLLEMKEAQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQ 600
Score = 72.4 bits (176), Expect = 2e-12
Identities = 170/858 (19%), Positives = 324/858 (37%), Gaps = 152/858 (17%)
Query: 51 ECQVKMLQGELGGIMGQEPENKGDHSKVRIYTSPCMIQEHQETQKRLSEVWQKVSQQDDL 110
E QV++ + EL ++ Q K+R+ ++EH+E+ ++V + QQ+
Sbjct: 227 ETQVRLHEDELLQLVTQADVETEMQQKLRVLQRK--LEEHEESLVGRAQVVDLL-QQELT 283
Query: 111 IQELRNKLACSNALVLEREKALIKLQADFASCTATHRYPPSSSEECEDIKKILKHLQEQK 170
E RN++ +E E ++ + E E+ K +L+ ++
Sbjct: 284 AAEQRNQILSQQLQQMEAEHNTLRNTVE---------------TEREESKILLEKME--- 325
Query: 171 DSQCLHVEEYQNLVKDLRVELEAVSEQKRNIMKDMMKLELDLHGLREETSAHIERKDKDI 230
L V E + +L+ E+ + EQ + +LE L ++ A +E K I
Sbjct: 326 ----LEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHI 381
Query: 231 TILQCRLQELQLEFTETQKLTLKKDKFLQEKDEMLQELEKKLTQVQNSLLKKEKELEKQQ 290
LQ QELQ + L + K LQ+K+E + + + Q+++ L +K KE+ +
Sbjct: 382 LSLQKTGQELQ---SACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQ-- 436
Query: 291 CMATELEMTVKEAKQDKSKEAECKALQAEVQKLKNSLEEAKQQERLAAQQAAQCKEEAAL 350
L + E A Q + N +A +E +A+ Q + E
Sbjct: 437 -FLNRLPLQQHET-----------ASQTSFPDVYNEGTQAVTEENIASLQKRVVELEN-- 482
Query: 351 AGCHLEDTQRKLQKGLLLDKQKADTIQELQRELQMLQKESSMAEKEQTSNRKRVEELSLE 410
+KG LL + ++EL+ E + L + ++ E + + E +
Sbjct: 483 ------------EKGALL--LSSIELEELKAENEKLSSQITLLEAQNRTGEADREVSEIS 528
Query: 411 LSEALRKLENSDKEKRQ--LQKTVAEQDMKMNDMLDRIKHQHREQGSIKCKLEEDLQEAT 468
+ + K +S +E Q L+ T +++ +++ +L +K E +K +L+ E
Sbjct: 529 IVDIANKRSSSAEESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAEEA 588
Query: 469 KLLEDKREQLKKSKEHEKLMEGELEALRQE------------------------------ 498
+HE L + E++ + E
Sbjct: 589 --------------DHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPA 634
Query: 499 FKKKDKTLKENSRKLEEENEN-LRAELQCCSTQLESSLNKYNTSQQVIQDLNKEIALQKE 557
+K+ + + SR EE + N EL+ + SL+ Q QD E+ K
Sbjct: 635 VEKEQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQD---ELERLKS 691
Query: 558 SLMSLQAQLDKALQ----------KEKHYLQTTITKEAYDALSRKSAAC-----QDDLTQ 602
++ L+ KA + KE L I + +A + SA +D L
Sbjct: 692 QILELELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEERDQLLS 751
Query: 603 ALEKLNHVT---SETKSLQQSLTQTQEKKAQLEEEIIAYE----ERMKKLNTELRKLRGF 655
+++L+ VT ++ K L+ +L + + ++ E A++ E++ L+ E +
Sbjct: 752 QVKELSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDNLLTEQIHSLSIEAKSKDVK 811
Query: 656 HQESELEVHAFDKKLEEMSCQVLQWQKQHQNDLKMLAAKEEQLREFQEEMAALKENLLED 715
+ + E+ + E S + Q Q QN + E++R ++ L + L +
Sbjct: 812 IEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEELSQALSQK 871
Query: 716 DKEPCCLPQWSVPK-----DTCRLYRGNDQIMTNL--EQWAKQQKVANEKLG-----NQL 763
+ E + Q + K + DQ +T + K ++ EK L
Sbjct: 872 ELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTL 931
Query: 764 REQVKYIA------KLSGEKDREPTRASSPNTTRPSSPSHSHLHSVMVHLQQENKKLKKE 817
+EQ+ ++ K E+D E + N S LQ E LKKE
Sbjct: 932 KEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKE----ELQHEFDLLKKE 987
Query: 818 IEEKKMKAENTRLCTKAL 835
E++K K + + K L
Sbjct: 988 NEQRKRKLQAALINRKEL 1005
Score = 65.5 bits (158), Expect = 2e-10
Identities = 127/693 (18%), Positives = 268/693 (38%), Gaps = 125/693 (18%)
Query: 5 NENTGEKLHLAQEQLALAGDKIASLERSLNLYRDKYQSSLSNIELLECQVKMLQGELGGI 64
N+ K +E+L + + L RS N +++ Q IE L+ + L ++ +
Sbjct: 2562 NKELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTAL 2621
Query: 65 MGQEPENKGDHSKVRIYTSPCMIQEHQETQKRLSEVWQKVSQQDDLIQELRNKLACSNAL 124
+ + +Y + ++E E RLS ++ S I EL +L C
Sbjct: 2622 Q--------EEGTLGLYHAQLKVKE--EEVHRLSALF---SSSQKRIAELEEELVC---- 2664
Query: 125 VLEREKALIKLQADFASCTATHRYPPSSSEECED-IKKILKHLQEQKDSQCLHVEEYQNL 183
+++E A E ED +KK LKHL
Sbjct: 2665 -VQKEAA-------------------KKVGEIEDKLKKELKHLHHDAGI----------- 2693
Query: 184 VKDLRVELEAVSEQKRNIMKDMMKLELDLHGLREET---SAHIERKDKDITILQC----- 235
+R E E E+ + +D++++E L + +E +A I+ + ++ LQ
Sbjct: 2694 ---MRNETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHA 2750
Query: 236 --RLQELQLEFTETQK--LTLKKDKFL-QEKDEMLQELEKKLTQVQNSLLKKEKELEKQQ 290
L EL+ ++ + K LK+ L +E+D +L E + + + L ++L +Q
Sbjct: 2751 NEELDELKRKYDASLKELAQLKEQGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQL 2810
Query: 291 CMATELEMTVKEAKQDKSKEAEC-----KALQAEVQKLKNSLEEAKQQERLAAQQAAQCK 345
E + + +D + + +LQ E L N LE+ ++ E + AAQ
Sbjct: 2811 LSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFRKSEEGKQRSAAQPS 2870
Query: 346 EEAALAGCHLEDTQRKLQKGLLLDKQKADTIQELQRELQMLQKESSMAEKEQTSNRKRVE 405
A + L+K + LQ + L KE +++ + +
Sbjct: 2871 TSPAEV--------QSLKKAM----------SSLQNDRDRLLKELKNLQQQYLQINQEIT 2912
Query: 406 ELSLELSEALRKLENSDKEKRQLQKTVAEQDMKMNDMLDRIKHQHREQGSIKCKLEEDLQ 465
EL L L++ ++ K + +Q+ + ++++ L +++ + + +++E
Sbjct: 2913 ELH-PLKAQLQEYQDKTKAFQIMQEELRQENLSWQHELHQLRMEKSSWEIHERRMKEQYL 2971
Query: 466 EATKLLEDKREQLKKSKEHEKLMEGELEALRQEFKKKDKTLKENSRKLEEENENLRAELQ 525
A + + L+ + + + L+ +++++ S + ++NL E +
Sbjct: 2972 MAISDKDQQLSHLQNLIRELRSSSSQTQPLKVQYQRQASPETSAS---PDGSQNLVYETE 3028
Query: 526 CCSTQLESSLNKYNTSQQVIQDLNKEIALQKESLMSLQAQL----DKALQKEKHY----- 576
TQL SL + + + IQ LN + E +L QL + ++HY
Sbjct: 3029 LLRTQLNDSLKEIHQKELRIQQLNSNFSQLLEEKNTLSIQLCDTSQSLRENQQHYGDLLN 3088
Query: 577 ----LQTTITK---------------EAYDALSRKS-----AACQDDLTQALEKLNHVTS 612
L+ + + + + + RKS Q ++A ++L +
Sbjct: 3089 HCAVLEKQVQELQAGPLNIDVAPGAPQEKNGVHRKSDPEELREPQQSFSEAQQQLCNTRQ 3148
Query: 613 ETKSLQQSLTQTQEKKAQLEEEIIAYEERMKKL 645
E L++ L + ++++ E + EE++++L
Sbjct: 3149 EVNELRKLLEEERDQRVAAENALSVAEEQIRRL 3181
Score = 35.8 bits (81), Expect = 0.18
Identities = 52/269 (19%), Positives = 112/269 (41%), Gaps = 41/269 (15%)
Query: 597 QDDLTQALEKLNHVTSETKSLQQSLTQTQEKKAQLEEEIIAYEERMKKLNTELRKLRGFH 656
Q+D+ + L + E K + ++K QL+++ A +E K + +++KL+ H
Sbjct: 47 QEDVQERLAYAEQLVVELKDI------IRQKDVQLQQKDEALQEERKAADNKIKKLK-LH 99
Query: 657 QESELEVHAFDKKLEEMSCQ---VLQWQKQHQNDLKMLAAKEEQLREFQEEMAALKENLL 713
+++L + +K +EEM Q VL + Q + + L+ ++ E + E+ +K L
Sbjct: 100 AKAKLT--SLNKYIEEMKAQGGTVLPTEPQSE---EQLSKHDKSSTEEEMEIEKIKHKLQ 154
Query: 714 EDDKEPCCLPQWSVPKDTCRLYRGNDQIMTNLEQWAKQQKVANEKLGNQLREQVKYIAKL 773
E ++ L + T Q T +E++ ++ QL+E+ ++I+ L
Sbjct: 155 EKEE----LISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQ--------QLQEKEEFISTL 202
Query: 774 SGEKDREPTRASSPNTTRPSS---PSHSHLH-----------SVMVHLQQENKKLKKEIE 819
+ + ++ R + LH V +QQ+ + L++++E
Sbjct: 203 QAQLSQTQAEQAAQQVVREKDARFETQVRLHEDELLQLVTQADVETEMQQKLRVLQRKLE 262
Query: 820 EKKMKAENTRLCTKALGPSRTESTQREKV 848
E + L T + QR ++
Sbjct: 263 EHEESLVGRAQVVDLLQQELTAAEQRNQI 291
>gi|55770834 centromere protein F [Homo sapiens]
Length = 3114
Score = 131 bits (330), Expect = 2e-30
Identities = 188/903 (20%), Positives = 393/903 (43%), Gaps = 115/903 (12%)
Query: 14 LAQEQLALAGDKIASLERSLNLYRDKYQSSLSNIELLECQVKMLQGELGGIMGQEPE--- 70
L+ + L DK E+ +L +D SL+ EL E Q+ L E ++ +
Sbjct: 2019 LSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCEL-ENQIAQLNKEKELLVKESESLQA 2077
Query: 71 --NKGDHSKVRIYTS-PCMIQEHQETQKRLSEVWQKVSQQDDLIQELRNKLACSNALVLE 127
++ D+ K+ + + + E E RLS ++V Q I++LR ++ L
Sbjct: 2078 RLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLH 2137
Query: 128 REKALIKLQADFASCTATHRYPPSSSEECEDIKKILKHLQEQKDSQCLHVEEYQNLVKDL 187
+ L + + R S ++ E++++ L+ +E ++ L E + V+ L
Sbjct: 2138 IAEKLKERE----------RENDSLKDKVENLERELQMSEENQELVILDAENSKAEVETL 2187
Query: 188 RVELEAVSEQKRNIMKDMMKLELDLHGLREETSAHIERKDKDITILQCRLQELQLEFTET 247
+ ++E ++ + + ELDL LR E L ++QE Q + +E
Sbjct: 2188 KTQIEEMA-------RSLKVFELDLVTLRSEKEN-----------LTKQIQEKQGQLSEL 2229
Query: 248 QKLTLKKDKFLQEKDE---MLQELEKKLTQVQNSLLKKEKELEKQQCMATELEMTVKEAK 304
KL L+EK++ ++E K ++ + LK+ E C E+ M E
Sbjct: 2230 DKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEI-MKATEQS 2288
Query: 305 QDKSKEAECKALQAEVQKLKNSLEEAKQQERLAAQQAAQCKEEAALAGCHLEDTQRKLQK 364
D E E + L+ ++KL+ LE ++++ QQ + + A L +E+ +R+L+
Sbjct: 2289 LDPPIEEEHQ-LRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEI 2347
Query: 365 GLLLDKQKADTIQELQRELQMLQKE----------------SSMAEKEQTSN-----RKR 403
+ A + + E++ L+ + + +EKE +N ++R
Sbjct: 2348 ARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQER 2407
Query: 404 VEELSLELSEALRKLENSDKEKRQL-QKTVAEQDM---KMNDMLDRIKHQHREQGSIKCK 459
+ EL + S L+ ++EK Q+ +K+ +M ++ ++ +R+ H +Q + K K
Sbjct: 2408 ISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAK 2467
Query: 460 LEEDLQEATKLLEDKREQLKKSKEHEK----LMEGELEALRQEFKKKDKTLKENSRKLEE 515
E++L + LE ++ QL + + K +++ + L QE + K+ K +E
Sbjct: 2468 -EQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDG----KQKLEKKDE 2522
Query: 516 ENENLRAELQCCSTQLESSLNKYNTSQQVIQDLNKEIALQKESLMSLQAQLDKALQKEKH 575
E L+ ++Q QL S L++ Q+ ++ N E+ + + L+ ++ + LQ +
Sbjct: 2523 EISRLKNQIQD-QEQLVSKLSQVEGEHQLWKEQNLEL---RNLTVELEQKI-QVLQSKNA 2577
Query: 576 YLQTT--ITKEAYDALSRKSAACQDDLTQALEKLNHVTSETKSLQQSLTQTQEKKAQLEE 633
LQ T + + +Y L + + D +EK+N +T++ LQ+ + + +K A+L+E
Sbjct: 2578 SLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQE 2637
Query: 634 EIIAYEER----MKKLNTELRKLRGFHQESELEVHAFDKKLE-----------EMSCQVL 678
E+ + R ++ L E++ + +E LE K L+ ++ ++
Sbjct: 2638 ELSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKVREEIA 2697
Query: 679 QWQ-KQHQNDLKMLAAKEEQLREFQEEMAALKENLLEDDKEPCCLPQ-------WSVPKD 730
++Q + H+ + K A + ++++ E+ +E L KE C Q S ++
Sbjct: 2698 EYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKL--TSKEECLSSQKLEIDLLKSSKEE 2755
Query: 731 TCRLYRGNDQIMTNLE-------QWAKQQKVANEKLGNQLREQVKYIAKLSGEKDREPTR 783
+ QI+ L+ ++ Q K NE+ +++ +K +L EK+
Sbjct: 2756 LNNSLKATTQILEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKE 2815
Query: 784 ASSPNTTRPSSPSHSHLHSVMVHLQQENKKLKKEIEEKKMKAEN--TRLCTKALGPSRTE 841
S + + + + + + L E K+LK+ +EEK +A+ + C+ + + E
Sbjct: 2816 LSQLQAAQEKQKTGTVMDTKVDELTTEIKELKETLEEKTKEADEYLDKYCSLLISHEKLE 2875
Query: 842 STQ 844
+
Sbjct: 2876 KAK 2878
Score = 105 bits (262), Expect = 2e-22
Identities = 162/759 (21%), Positives = 315/759 (41%), Gaps = 94/759 (12%)
Query: 60 ELGGIMGQEPENKGDHSKVRIYTSPCMIQEHQETQKRLS---------EVWQKVSQQDDL 110
EL I+G+ + D S+ Y S C +HQE +R+ E+ S ++D+
Sbjct: 1827 ELEKIVGELKKENSDLSEKLEYFS-C---DHQELLQRVETSEGLNSDLEMHADKSSREDI 1882
Query: 111 IQELRNKLACSNALVLEREKALIKLQADFASCTATHRYPPSSSEECEDIKKILKHLQEQK 170
+ L+ E L +++++ AS Y + E + K L+ E K
Sbjct: 1883 GDNVAKVNDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDNENK 1942
Query: 171 DSQCLHVEEYQNLV----KDLRVELEAVSEQKR---NIMKDMMKLELDLHGLREETSAHI 223
+ +EE ++V LR EL+ +S++ + + M + +L + E I
Sbjct: 1943 QKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCI 2002
Query: 224 ERKDKDITILQCRLQELQLEFTETQKLTLKKDKFLQ--EKDEMLQELEKKLTQVQNSLLK 281
+ + ++ LQ L + +E K + LQ EKD L K + Q + L
Sbjct: 2003 QVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLN 2062
Query: 282 KEKEL---EKQQCMATELEMTVKEAKQDKSKEAECKALQAEVQKLKNSLEEAKQQ----E 334
KEKEL E + A E ++ K+ EA +L ++ EE Q E
Sbjct: 2063 KEKELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIE 2122
Query: 335 RLAAQQAAQCKEEAALAGCHLEDTQRKLQKGLLLDKQKADTIQELQRELQMLQKESSMAE 394
+L + A K++ +A KL++ + D ++ L+RELQM ++ +
Sbjct: 2123 KLRVRIEADEKKQLHIA--------EKLKERERENDSLKDKVENLERELQMSEENQELVI 2174
Query: 395 KEQTSNRKRVEELSLELSEALRKLENSD-------KEKRQLQKTVAEQDMKMND---MLD 444
+ +++ VE L ++ E R L+ + EK L K + E+ ++++ +L
Sbjct: 2175 LDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLS 2234
Query: 445 RIKHQHREQGSIKCKLEEDLQEATKLLEDKREQLKKSKEHEKLMEGELEALRQEFKKKDK 504
K E+ + +++E+ + A ++L++ QLK+ E + G+ E ++ + D
Sbjct: 2235 SFKSLLEEKEQAEIQIKEESKTAVEMLQN---QLKELNEAVAALCGDQEIMKATEQSLDP 2291
Query: 505 TLKENSRKLEEENENLRAELQCCSTQLESSLNKYNTSQQVIQDLNKEIALQKESLMSLQA 564
+ EE LR ++ +LE+ K Q +++ L K + +L+
Sbjct: 2292 PI--------EEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLER 2343
Query: 565 QLDKALQKEKHYLQTTITKEAYDALSRKSAACQDDLTQALEKLNHVTSETKSLQQSLTQT 624
+L+ A ++H ALE N E ++L+ +
Sbjct: 2344 ELEIARTNQEH--------------------------AALEAENS-KGEVETLKAKIEGM 2376
Query: 625 QEKKAQLEEEIIAYEERMKKLNTELRKLRGFHQESELEVHAFDKKLEEMSCQVLQWQKQH 684
+ LE +++ + L EL+K + E E+ +F+ L+E + +Q +++
Sbjct: 2377 TQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQEKVQMKEKS 2436
Query: 685 QNDLKMLAAKEEQLREFQEEMAALKENLLEDDKEPCCLPQWSVPKDTCRLYRGNDQIMTN 744
++ML + QL+E E +AA L +D+E C + ++ L Q++
Sbjct: 2437 STAMEML---QTQLKELNERVAA-----LHNDQEACKAKEQNLSSQVECLELEKAQLLQG 2488
Query: 745 LEQWAKQQKVANEKLGNQLREQVKYIAKLSGEKDREPTR 783
L++ AK + + N L ++V+ + +KD E +R
Sbjct: 2489 LDE-AKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISR 2526
Score = 97.8 bits (242), Expect = 4e-20
Identities = 161/849 (18%), Positives = 338/849 (39%), Gaps = 144/849 (16%)
Query: 37 RDKYQSSLSNIELLECQVKMLQGELGG-IMGQEPENKGDHSKVRIYTSPCMIQEHQETQK 95
++KY + + LE +VK LQ + + Q N D ++ + +S Q+ ++T
Sbjct: 168 KEKYNKEVEERKRLEAEVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQ-EKTPS 226
Query: 96 RLSEVWQKVSQQDDLIQELRNKLACSNALVLEREKALIKLQADFASCTATHRYPPSSSEE 155
LS Q+ + D ++ E+E + A + +SS
Sbjct: 227 HLSSNSQRTPIRRDF---------SASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSS- 276
Query: 156 CEDIKKILKHLQEQKDSQCLHVEEYQNLVKDLRVELEAVSEQKRNIMKDMMKLELDLHGL 215
HL +Q +Q +E +N + +L + L+ ++ + + +L+L L
Sbjct: 277 --------PHLLDQLKAQ---NQELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKA 325
Query: 216 REE-----------------TSAHIERKDKDITILQCRLQELQLEFTETQKLTLKKDKFL 258
+ E T+A ++ T L+ +L++L T+ L+ ++
Sbjct: 326 KVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKL------TEDLSCQRQNAE 379
Query: 259 QEKDEMLQELEKKLTQVQNSLLKKEKELE--KQQCMATELEMTVKEAKQDKSK----EAE 312
+ + Q++++K + Q L ++++ + Q+C+ + +T +E +Q K+ +AE
Sbjct: 380 SARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLT-QELQQAKNMHNVLQAE 438
Query: 313 CKALQAEVQKLKNSLEEAKQQERLAAQ--QAAQCKEEAALAGCHLEDTQRKLQKGLLLDK 370
L + Q+L+N+LEE KQ+ A Q QA+Q KE
Sbjct: 439 LDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKE------------------------ 474
Query: 371 QKADTIQELQRELQMLQKESSMAEKEQTSNRKRVEELSLELSEALRKLENSDKEKRQLQK 430
EL+R ++ ++KE+++ + + V L EL + L S +++
Sbjct: 475 ------NELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKA 528
Query: 431 TVAEQDMKMNDMLDRIKHQHREQGSIKCKL------------EEDLQEATKLLEDKREQL 478
Q+ + D+ ++I Q K KL ++ L++ +E ++L
Sbjct: 529 KNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKL 588
Query: 479 KKSKEHEKLMEGELEALRQEFK--KKDKTL----KENSRKLEEENENLRAELQCCSTQLE 532
K+++ K + LE ++E++ K++KTL K + KL + E+ + LQ LE
Sbjct: 589 SKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLE 648
Query: 533 SSLNKYNTSQQVIQDLNKEIALQKESLMSLQAQLDKALQKEKHYLQTTITKEAYDALSRK 592
+ L + + + + +E+L L L + ++T K AY L +K
Sbjct: 649 TCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVET--QKLAYMELQQK 706
Query: 593 SAACQDDLTQALEKLNHVTSETKSLQQSLTQTQEKKAQLEEEIIAYEERMKKLNTELRKL 652
A D Q +++ ++ +T L + + K L EI+ + + L+ E L
Sbjct: 707 -AEFSDQKHQ--KEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESL 763
Query: 653 RGFHQESELEVHAFDKKLEEMSCQVLQWQKQHQNDLKMLAAKEEQLREFQEEMAALKENL 712
R + + L + HQ L LA ++ ++
Sbjct: 764 RDLLKSKDAS---------------LVTNEDHQRSL--LAFDQQPAMHHSFANIIGEQGS 806
Query: 713 LEDDKEPCCLPQWSVPKDTCRLYRGNDQIMTNLEQWAKQQKVANEKLGNQLREQVKYIAK 772
+ ++ C L PK++ L D + +LE + +++ + L++Q + + +
Sbjct: 807 MPSERSECRLEADQSPKNSAILQNRVDSLEFSLE--------SQKQMNSDLQKQCEELVQ 858
Query: 773 LSGEKDREPTRA----------SSPNTTRPSSPSHSHLHSVMVHLQQ-ENKKLKKEIEEK 821
+ GE + +A +S ++ + +H + V L ENK+ + ++
Sbjct: 859 IKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLND 918
Query: 822 KMKAENTRL 830
K++ E +
Sbjct: 919 KVETEQAEI 927
Score = 95.5 bits (236), Expect = 2e-19
Identities = 214/1019 (21%), Positives = 407/1019 (39%), Gaps = 226/1019 (22%)
Query: 3 NHNENTGEKLHLAQEQLALAGDKIASLERSLNLYRDKYQSSLSNIELLECQVKMLQGELG 62
N+ E +KL A++ + K L RS+ + + S+ E +V L+ EL
Sbjct: 451 NNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELK 510
Query: 63 GIMG--QEPENKGDHSKVRIYTSPCMIQEHQE---------TQKRLSEVWQKVSQQDDL- 110
I + +N + K + + M+++ QE T ++L + +Q D
Sbjct: 511 NIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQRDCS 570
Query: 111 ----------IQELRNKL--------ACSNALVLER-EKALIKLQADFASC--TATHRYP 149
I++L +KL A +AL L++ E +K + SC + +
Sbjct: 571 QDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLL 630
Query: 150 PSSSEECEDIKKILKHLQEQKDSQCLHVEEYQNLVKDLRVELEAVSEQKRNI--MKDMMK 207
E E+++ + HL+ +Q + EY V+ L ++ E +S + RN+ + D
Sbjct: 631 TQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKS 690
Query: 208 LELDLH-----GLREETSAHIERKDKDITILQCRLQEL--QLEFTETQKLTLKKDKFLQE 260
+E++ L+++ ++ K+I + + +L Q+E E KL L ++ + +
Sbjct: 691 VEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLE-HKLQLLSNE-IMD 748
Query: 261 KDEMLQELEKKLTQVQNSLLKKEKEL-------------EKQQCMATELEMTVKEAKQDK 307
KD Q+L + +++ L K+ L ++Q M + E
Sbjct: 749 KDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMP 808
Query: 308 SKEAECK-----------ALQAEVQKLKNSLEEAKQQERLAAQQAAQCKEEAALAG---- 352
S+ +EC+ LQ V L+ SLE KQ + + QC+E + G
Sbjct: 809 SERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQ---MNSDLQKQCEELVQIKGEIEE 865
Query: 353 --------------------------------------CHLEDTQRKLQKGLLLDKQKAD 374
LE+ +++LQ LL DK + +
Sbjct: 866 NLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQ--LLNDKVETE 923
Query: 375 --TIQELQ----------RELQMLQKESSMAEKEQTS----NRKRVEELSLELSEALRKL 418
IQEL+ +ELQ+L + S+ +KE +S N++ +EEL+ E + L+++
Sbjct: 924 QAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQE-NGTLKEI 982
Query: 419 ENS-DKEKRQL-QKT------VAEQDMKMNDMLDRIKHQHREQGSIKCKLEEDLQEATKL 470
S ++EK L QK+ + E++ ++++ D+ K + K L + +E
Sbjct: 983 NASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQE-------KLILLQRCEETGNA 1035
Query: 471 LEDKREQLKKSKEHEKLME--------------GELEALRQEFKKKDKTLKENSRKLEEE 516
ED ++ K ++E +E ELE L++ F K+ + EE
Sbjct: 1036 YEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQEFLTKLAFAEER 1095
Query: 517 NENLRAELQCCSTQLESSL-NKYNTSQQVIQDLNKEIALQKESLMSLQAQLDKALQKEKH 575
N+NL EL+ L S + + N S+ L +EI KE +Q +++ LQ+ +
Sbjct: 1096 NQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQ 1155
Query: 576 YLQTTITKEAYDALSRKSAACQDDLTQALEKLNHVTSETK--------SLQQSLTQTQEK 627
++ TK ++ + +S ++ + + + N + + SL Q +
Sbjct: 1156 LMKVMKTK--HECQNLESEPIRNSVKERESERNQCNFKPQMDLEVKEISLDSYNAQLVQL 1213
Query: 628 KAQLEEEIIAYEERMKK---LNTELRKLRGFHQESELEVHAFDKKLEEMS----CQVLQW 680
+A L + + +E K+ L EL+ +RG + S L+ D + +E+S C++
Sbjct: 1214 EAMLRNKELKLQESEKEKECLQHELQTIRGDLETSNLQ----DMQSQEISGLKDCEIDAE 1269
Query: 681 QK---------QHQND-------LKMLAAKEEQLREFQEEMAALKENL---LEDDKEPCC 721
+K QND L+ K +L + E + A K L L D + C
Sbjct: 1270 EKYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQAEKYELVTELNDSRSECI 1329
Query: 722 LPQWSVPKDTCRLYRGNDQIMTNLEQWAKQQKVANEKLGNQLREQVKYIAKLSGEKDREP 781
+ ++ +L + K+ N+ G E V+ I GE +P
Sbjct: 1330 TATRKMAEEVGKL--------------LNEVKILNDDSGLLHGELVEDIP--GGEFGEQP 1373
Query: 782 TRASSPNTTRPSSPSHSHLH------SVMVHLQQ-ENKKLKKEIEEKKMKAENTRLCTK 833
P + P S+S+ H V +H + + K L + E K + ++ ++ +K
Sbjct: 1374 NE-QHPVSLAPLDESNSYEHLTLSDKEVQMHFAELQEKFLSLQSEHKILHDQHCQMSSK 1431
Score = 92.4 bits (228), Expect = 2e-18
Identities = 171/816 (20%), Positives = 330/816 (40%), Gaps = 121/816 (14%)
Query: 92 ETQKRLSEVWQKVSQQDDLIQELRNKLACSNALVLEREKALIKLQADFASCTATHRYPPS 151
E + RL +++ Q + QEL+ +L + ++E+EK L K + + TA +
Sbjct: 296 ELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQY---DQ 352
Query: 152 SSEECEDIKKILKHLQEQKDSQCLHVEEYQNLVKDLRVELE-AVSEQKRNIMKDMMKLEL 210
+S + +++ LK L E D C + QN + R LE + E+++ +++ + +
Sbjct: 353 ASTKYTALEQKLKKLTE--DLSC----QRQN-AESARCSLEQKIKEKEKEFQEELSRQQR 405
Query: 211 DLHGLREETSAHIERKDKDITILQCRL-QELQLEFTETQKLTLKKDKFLQEKDEMLQELE 269
L D++ ++ RL QELQ L + DK K Q+LE
Sbjct: 406 SFQTL-----------DQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVK----QQLE 450
Query: 270 KKLTQVQNSLLKKEKELEKQQCMATELEMTVKEAKQD--------KSKEAECKALQAEVQ 321
L + + L + E+ + Q EL +++E K++ + K E L+AE++
Sbjct: 451 NNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELK 510
Query: 322 KLKNSLEEAKQ-------------------QERLAAQQAAQCKEEAALAGCHLEDTQRKL 362
+K L +++ QE++ Q+ + E+ LA LE QR
Sbjct: 511 NIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLE-KQRDC 569
Query: 363 QKGLLLDKQKADTIQELQRELQMLQKESSMAEKEQTSNRKRVEELSLE-------LSEAL 415
+ LL K++ I++L +L +KES +K EEL E SE
Sbjct: 570 SQDLL--KKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENE 627
Query: 416 RKLENSDKEKRQLQKTV-------AEQDMKMNDMLDRIKHQHREQGSIKCKLEEDLQEAT 468
+ L + EK LQ + Q +K ++ +R++ ++ + L +++
Sbjct: 628 KLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDREN----LSVEIRNLH 683
Query: 469 KLLEDKREQLKKSKEHEKLMEGELEALRQEFKKKDKTLKENSRKLEEENENLRAELQCCS 528
+L+ K +++ K ++ + E Q+ +K+ + + + +L + E+L +LQ S
Sbjct: 684 NVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLS 743
Query: 529 TQLESSLNKYNTSQQVIQDLNKEIALQKESLMSLQAQL------DKAL-----QKEKHYL 577
N+ + QDL+ E ++ L S A L ++L Q H+
Sbjct: 744 -------NEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHS 796
Query: 578 QTTITKEAYDALSRKSAACQDDLTQALEKLNHVTSETKSLQQSLTQTQEKKAQLEEEIIA 637
I E S +S C+ + Q+ + + + SL+ SL ++ + L+++
Sbjct: 797 FANIIGEQGSMPSERS-ECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEE 855
Query: 638 YEERMKKLNTELRKLRGFHQESELEVHAFDKKLEE-------MSCQVLQWQKQHQNDLKM 690
+ ++ L K HQ E KL+E + + L + + +L++
Sbjct: 856 LVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQL 915
Query: 691 LAAK-EEQLREFQE-------------EMAALKENLLEDDKEPCCLPQWSVPKDTCRLYR 736
L K E + E QE E+ L E L + KE + + ++ L +
Sbjct: 916 LNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLN-KREIEELTQ 974
Query: 737 GN---DQIMTNLEQWAKQQKVANEKLGNQLREQVKYIAKLSGEKDREPTRASSPNTTRPS 793
N +I +L Q +E N + E+ K I++LS + +E + +
Sbjct: 975 ENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQE--KLILLQRCEET 1032
Query: 794 SPSHSHLHSVMVHLQQENKKLKKEIEEKKMKAENTR 829
++ L Q++N KL+ + E EN +
Sbjct: 1033 GNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRK 1068
Score = 89.4 bits (220), Expect = 1e-17
Identities = 175/876 (19%), Positives = 333/876 (38%), Gaps = 215/876 (24%)
Query: 149 PPSSSEECEDIKKILKHLQEQKDSQCLHVEEYQNLVKDLRVELEAVSEQKRNIMKDMMKL 208
P + ++ ++++ L L+++K + ++ + ++ + ++E + N+ ++ +L
Sbjct: 13 PTRALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRL 72
Query: 209 ELDLHGLREETSAHIERKDKDITILQCRLQELQLEFTETQKLTLKK--DKFLQEKDEMLQ 266
+++ E+T I + +++E Q+ F E Q + KK +K QE
Sbjct: 73 -MEICESLEKTKQKISH--------ELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKS 123
Query: 267 ELEKKLTQVQNSLLKKEKELEKQQCMATEL---------------EMTVKEAKQDKSKEA 311
ELE+ Q++ + Q+ T L E KE ++ K EA
Sbjct: 124 ELERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEA 183
Query: 312 ECKALQAEVQKLKNSLEEAKQQER-LAAQQAAQC--KEEAALAGCHLEDTQRK------- 361
E KALQA +K +L +A R +A QA+ + HL ++
Sbjct: 184 EVKALQA--KKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDF 241
Query: 362 -----------------LQKGL---------------LLDKQKADTIQELQRELQMLQKE 389
LQ G LLD+ KA QEL+ ++ L+
Sbjct: 242 SASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQN-QELRNKINELELR 300
Query: 390 SSMAEKEQTSNRKRVEELSLELSEALRKLENSDKEK------RQLQKTVAEQD------- 436
EKE + +EL L+L +A K+E +KEK +L +T A+ D
Sbjct: 301 LQGHEKEMKGQVNKFQELQLQLEKA--KVELIEKEKVLNKCRDELVRTTAQYDQASTKYT 358
Query: 437 ---MKMNDMLDRIKHQHREQGSIKCKLEEDLQEATKLLEDK------------------- 474
K+ + + + Q + S +C LE+ ++E K +++
Sbjct: 359 ALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMK 418
Query: 475 ---REQLKKSKEHEKLMEGELEAL------------------------------------ 495
++L+++K +++ EL+ L
Sbjct: 419 ARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELR 478
Query: 496 --RQEFKKKDKTLKENSRKLEEENENLRAEL----QCC--STQLESSLNKYNTSQQ-VIQ 546
+E KK++ LK +S + E +L AEL QC S + NTSQ+ +++
Sbjct: 479 RSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLR 538
Query: 547 DLNKEIALQKESL---------MSLQAQLD---KALQKEKHYLQ---------------- 578
DL ++I Q+ SL L+ Q D L+K +H+++
Sbjct: 539 DLQEKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKAL 598
Query: 579 ---TTITKEAYDALSRKSA--AC-----QDDLTQALEKLNHVTSETKSLQQSLTQTQEKK 628
+ K+ Y+ L + +C + LTQ + ++ S+ L+ L Q K
Sbjct: 599 LSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKS 658
Query: 629 AQLEEEIIAYEERMKKLNTELRKLRGFHQESELEVHAFDKKLEEMSCQVLQWQKQHQNDL 688
+ E + E + L+ E+R L +EV E+ + ++HQ ++
Sbjct: 659 HEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEI 718
Query: 689 KMLAAKEEQL----REFQEEMAALKENLLEDDKEPCCLPQWSVPKDTCR-LYRGNDQIMT 743
+ + K QL + + ++ L +++ D+ C ++ R L + D +
Sbjct: 719 ENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDR---CYQDLHAEYESLRDLLKSKDASLV 775
Query: 744 NLEQWAK------QQKVANEKLGNQLREQVKYIAKLSG---EKDREPTRA----SSPNTT 790
E + QQ + N + EQ ++ S E D+ P + + ++
Sbjct: 776 TNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSL 835
Query: 791 RPSSPSHSHLHSVMVHLQQENKKLKKEIEEKKMKAE 826
S S ++S + +E ++K EIEE MKAE
Sbjct: 836 EFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAE 871
Score = 83.6 bits (205), Expect = 8e-16
Identities = 157/790 (19%), Positives = 313/790 (39%), Gaps = 144/790 (18%)
Query: 98 SEVWQKVSQQDDLIQELRNKLAC----SNALVLEREKALIKLQA-DFASCTA----THRY 148
+E WQ+ + + E+ +KLA + L LE E A ++LQ D +S + T
Sbjct: 1606 NEQWQQ--KLTSVTLEMESKLAAEKKQTEQLSLELEVARLQLQGLDLSSRSLLGIDTEDA 1663
Query: 149 PPSSSEECEDIKKILKHLQEQKDSQCLHVEEYQNLVKDLRVELEAVSE------------ 196
+E C+ K+ E+ +H ++ +DL +++E ++E
Sbjct: 1664 IQGRNESCDISKEHTSETTERTPKHDVHQICDKDAQQDLNLDIEKITETGAVKPTGECSG 1723
Query: 197 ------------QKRNIMKDMMKLELDLHGLREETSAHIERKDKDITILQCRLQELQLEF 244
+ + EL G +DI LQ R++
Sbjct: 1724 EQSPDTNYEPPGEDKTQGSSECISELSFSGPNALVPMDFLGNQEDIHNLQLRVK------ 1777
Query: 245 TETQKLTLKKDKFLQEKDEMLQELEKKLTQVQNSLLKKEKELEKQQCMATELEMTVKEAK 304
ET L+ ++++D ++ L ++ ++ + L +E +L + ELE V E K
Sbjct: 1778 -ETSNENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIEACIELEKIVGELK 1836
Query: 305 QDKSKEAE-CKALQAEVQKLKNSLEEAKQQERLAAQQAAQCKEE------AALAGCHLE- 356
++ S +E + + Q+L +E ++ A + E A + E
Sbjct: 1837 KENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWKER 1896
Query: 357 --DTQRKLQKGLLLDKQKADTIQE---LQRELQMLQKESSMAEKEQTSNRKRVEELSLEL 411
D + +L + + +KA E L+ +L+++Q E EK+ + +K + L EL
Sbjct: 1897 FLDVENELSR---IRSEKASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEEL 1953
Query: 412 SEALRKLENSDKEKRQLQ---KTVAEQDMKMNDMLDRIKHQHREQGSIKCKLEEDLQEAT 468
S E+ QL+ T++++ ++ + +++K + +E LE E
Sbjct: 1954 SVV-------TSERNQLRGELDTMSKKTTALDQLSEKMKEKTQE-------LESHQSECL 1999
Query: 469 KLLEDKREQLKKSKEHEKLMEGELEALRQEFKKKDKT-LKENSRKLEEENENLRAELQCC 527
++ ++K+ E + + ++ L KDKT L+E + LE++++ L
Sbjct: 2000 HCIQVAEAEVKEKTELLQTLSSDVSEL-----LKDKTHLQEKLQSLEKDSQAL------- 2047
Query: 528 STQLESSLNKYNTSQQVIQDLNKEIALQKESLMSLQAQLDKA---------------LQK 572
SL K Q+ Q LNKE L + SLQA+L ++ ++K
Sbjct: 2048 ------SLTKCELENQIAQ-LNKEKELLVKESESLQARLSESDYEKLNVSKALEAALVEK 2100
Query: 573 EKHYLQTTITKEAYDALSRKSAACQDDLTQALEKLNHVTSETKSLQQSLTQTQEKKAQLE 632
+ L+ + T+E L R + + +K H+ + K ++ ++K LE
Sbjct: 2101 GEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLE 2160
Query: 633 EEIIAYEERMKKLNTELRKLRGFHQESELEVHAFDKKLEEMSCQVLQWQKQHQNDLKMLA 692
E+ EE + + + + + + ++ + L+ ++ + + +N K +
Sbjct: 2161 RELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQ 2220
Query: 693 AKEEQLREFQEEMAALKENLLEDDKEPCCLPQWSVPKDTCRLYRGNDQIMTNLEQWAKQQ 752
K+ QL E + +++ K L E ++ Q ++
Sbjct: 2221 EKQGQLSELDKLLSSFKSLLEEKEQAEI--------------------------QIKEES 2254
Query: 753 KVANEKLGNQLREQVKYIAKLSGEKDREPTRASSPNTTRPSSPSHSHLHSVMVHLQQENK 812
K A E L NQL+E + +A L G D+E +A+ + P H +S+ E
Sbjct: 2255 KTAVEMLQNQLKELNEAVAALCG--DQEIMKATEQSLDPPIEEEHQLRNSI------EKL 2306
Query: 813 KLKKEIEEKK 822
+ + E +EKK
Sbjct: 2307 RARLEADEKK 2316
Score = 75.5 bits (184), Expect = 2e-13
Identities = 156/767 (20%), Positives = 313/767 (40%), Gaps = 119/767 (15%)
Query: 6 ENTGEKLHLAQEQLALAGDKIASLERSLNLYRDKYQSSLSNIELLECQVKMLQGELGGIM 65
EN ++L L +++ +I L++S +L D SL ++LL + + + E+ I+
Sbjct: 907 ENKEKELQLLNDKVETEQAEIQELKKSNHLLED----SLKELQLLSETLSLEKKEMSSII 962
Query: 66 G---QEPENKGDHSKVRIYTSPCMIQEHQETQKRLSEVWQKVSQQDDLIQELRNKLACSN 122
+E E + + + QE ++ + +++ I EL ++
Sbjct: 963 SLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEK 1022
Query: 123 ALVLEREKALIKLQADFASCTATHRYPPSSSE--------ECEDIKKILKHLQEQKDSQC 174
++L+R + D + + S E CE+ K L+ L+E
Sbjct: 1023 LILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEA----- 1077
Query: 175 LHVEEYQNLVKDLRVELEAVSEQKRNIMKDMMKLELDLHGLREETSAHIERKDKDITILQ 234
+E+Q + +L E+ +N+M ++LE LR E + + + L+
Sbjct: 1078 -FAKEHQEFL----TKLAFAEERNQNLM---LELETVQQALRSEMTDNQNNSKSEAGGLK 1129
Query: 235 CRLQELQLEFTETQKLTLKKDKFLQEKDEMLQELEKK-------LTQVQNSLLKKEKELE 287
+ L+ E + QK + + LQE +++++ ++ K ++NS+ KE+E E
Sbjct: 1130 QEIMTLKEEQNKMQK---EVNDLLQENEQLMKVMKTKHECQNLESEPIRNSV--KERESE 1184
Query: 288 KQQC-MATELEMTVKEAK----------------------QDKSKEAECKALQAEVQKLK 324
+ QC ++++ VKE Q+ KE EC LQ E+Q ++
Sbjct: 1185 RNQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKEC--LQHELQTIR 1242
Query: 325 NSLEEAKQQERLAAQQAAQCKEEAALAGCHLEDTQRKLQKGLLLDKQKADTIQELQRELQ 384
LE + Q+ Q +E + L C ++ ++ + L + D LQ LQ
Sbjct: 1243 GDLETSNLQDM-------QSQEISGLKDCEIDAEEKYISGPHELSTSQNDNAH-LQCSLQ 1294
Query: 385 MLQKESSMAEKEQTSNRKRVEELSLELSEALRKLENSDKEKRQLQKTVAEQDMKMNDMLD 444
+ + EK E L E E + +L +S E + +AE+ + +L+
Sbjct: 1295 TTMNKLNELEKI-------CEILQAEKYELVTELNDSRSECITATRKMAEE---VGKLLN 1344
Query: 445 RIKHQHREQGSIKCKLEEDLQEATKLLEDKREQ-------LKKSKEHEKLMEGELEALRQ 497
+K + + G + +L ED+ + E EQ L +S +E L
Sbjct: 1345 EVKILNDDSGLLHGELVEDIPGG-EFGEQPNEQHPVSLAPLDESNSYEHLT--------- 1394
Query: 498 EFKKKDKTLKENSRKLEEENENLRAELQCCSTQLESSLNKYNTSQQVIQDLNKEIALQKE 557
DK ++ + +L+E+ +L++E + Q +K + Q + L E +
Sbjct: 1395 ---LSDKEVQMHFAELQEKFLSLQSEHKILHDQHCQMSSKMSELQTYVDSLKAENLVLST 1451
Query: 558 SLMSLQAQLDKALQKE-KHYLQTTITKEAYDALSRKSAACQDDLTQALEKLNHVTSETKS 616
+L + Q L K +Q + L +++ S S+ +AL + S +
Sbjct: 1452 NLRNFQGDLVKEMQLGLEEGLVPSLSSSCVPDSSSLSSLGDSSFYRALLEQTGDMSLLSN 1511
Query: 617 LQQSLTQTQEKKAQLEEEIIA--YEERMKKLNTELRKLRGFHQ-ESELEVH--AFDKKLE 671
L+ +++ Q ++E + EE + + T +G + ES EV+ + +K E
Sbjct: 1512 LEGAVSANQ---CSVDEVFCSSLQEENLTRKETPSAPAKGVEELESLCEVYRQSLEKLEE 1568
Query: 672 EMSCQVLQWQKQHQNDLKMLAAKEEQLREFQEEMAALKENLLEDDKE 718
+M Q + K+ Q +L+ L + E Q E+ L++ L ++++
Sbjct: 1569 KMESQGIMKNKEIQ-ELEQLLSSERQ------ELDCLRKQYLSENEQ 1608
Score = 67.0 bits (162), Expect = 7e-11
Identities = 122/609 (20%), Positives = 233/609 (38%), Gaps = 64/609 (10%)
Query: 164 KHLQEQKDSQCLHVEEYQNLVKDLRVELEAVSEQKRNIMKDMMKLELDLHGLREETSAHI 223
+HL +H E Q L+ E + + +Q + M +L+ + L+ E
Sbjct: 1391 EHLTLSDKEVQMHFAELQEKFLSLQSEHKILHDQHCQMSSKMSELQTYVDSLKAEN---- 1446
Query: 224 ERKDKDITILQCRLQELQLEFTETQKLTLKKDKFLQEKDEMLQELEKKLTQVQNSLLKKE 283
+L L+ Q + + +L L++ + + + +S +
Sbjct: 1447 -------LVLSTNLRNFQGDLVKEMQLGLEEGLVPSLSSSCVPDSSSLSSLGDSSFYRAL 1499
Query: 284 KELEKQQCMATELEMTVKEAKQDKSKEAECKALQAEVQKLKNS-------LEEAKQQERL 336
E + + LE V A Q E C +LQ E K + +EE + +
Sbjct: 1500 LEQTGDMSLLSNLEGAVS-ANQCSVDEVFCSSLQEENLTRKETPSAPAKGVEELESLCEV 1558
Query: 337 AAQQAAQCKEEAALAGCHLEDTQRKLQKGLLLDKQKADTI--QELQRELQMLQKESSMA- 393
Q + +E+ G ++L++ L ++Q+ D + Q L Q QK +S+
Sbjct: 1559 YRQSLEKLEEKMESQGIMKNKEIQELEQLLSSERQELDCLRKQYLSENEQWQQKLTSVTL 1618
Query: 394 --EKEQTSNRKRVEELSLELSEALRKLENSDKEKRQLQKTVAEQDMKMNDMLDRIKHQHR 451
E + + +K+ E+LSLEL A +L+ D R L E ++ + I +H
Sbjct: 1619 EMESKLAAEKKQTEQLSLELEVARLQLQGLDLSSRSLLGIDTEDAIQGRNESCDISKEHT 1678
Query: 452 EQGSIKCK-------LEEDLQEATKLLEDKREQLKKSKEHEKLMEGELEALRQEFKKKDK 504
+ + + ++D Q+ L +K + K + + E +DK
Sbjct: 1679 SETTERTPKHDVHQICDKDAQQDLNLDIEKITETGAVKPTGECSGEQSPDTNYEPPGEDK 1738
Query: 505 T--LKENSRKLEEENENLRAELQCCSTQ---------LESSLNKYNTSQQVIQDLNKEIA 553
T E +L N + Q ++ + N+ VI+D ++++
Sbjct: 1739 TQGSSECISELSFSGPNALVPMDFLGNQEDIHNLQLRVKETSNENLRLLHVIEDRDRKV- 1797
Query: 554 LQKESLMSLQAQLDKALQKEKHYLQTTITKEAYDALSRKSAACQDDLTQALEKLNHVTSE 613
ESL++ +LD L ++ L T I EA L + + + + EKL + + +
Sbjct: 1798 ---ESLLNEMKELDSKLHLQEVQLMTKI--EACIELEKIVGELKKENSDLSEKLEYFSCD 1852
Query: 614 TKSLQQSLTQTQEKKAQLE--------EEI--------IAYEERMKKLNTELRKLRGFHQ 657
+ L Q + ++ + LE E+I +++ER + EL ++R
Sbjct: 1853 HQELLQRVETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKA 1912
Query: 658 ESELEVHAFDKKLEEMSCQVLQWQKQHQNDLKMLAAKEEQLREFQEEMAALKENLLEDDK 717
E E + LE + + L +K ++N K++ EE+L E L+ L K
Sbjct: 1913 SIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSK 1972
Query: 718 EPCCLPQWS 726
+ L Q S
Sbjct: 1973 KTTALDQLS 1981
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 131 bits (329), Expect = 3e-30
Identities = 146/673 (21%), Positives = 287/673 (42%), Gaps = 36/673 (5%)
Query: 170 KDSQCLHVEEYQNLVKDLRVELEAVSEQ---KRNIMKDMMKLELDLHGLREETSAHIERK 226
K+ + + V E Q ++ E+E + Q ++ +++ ++ E +L EE A + K
Sbjct: 850 KEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAK 909
Query: 227 DKDITI----LQCRLQELQLEFTETQKLTLKKDKFLQEKDEMLQELEKKLTQVQNSLLKK 282
+++ L+ R++E + Q K + +QE +E L+E E ++Q +
Sbjct: 910 KQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTT 969
Query: 283 E---KELEKQQCMATELEMTV-KEAKQDKSKEAECKALQAEVQKLKNSLEEAKQQERLAA 338
E K+LE++Q + + + KE K + + AE E ++ SL + K +
Sbjct: 970 EAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMI 1029
Query: 339 QQAAQCKEEAALAGCHLEDTQRKLQKGLLLDKQKADTIQELQRELQMLQKESSMAEKEQT 398
+ LE T+RKL+ +D I ELQ ++ L+ + + E+E
Sbjct: 1030 TDLEERLRREEKQRQELEKTRRKLEGD---STDLSDQIAELQAQIAELKMQLAKKEEELQ 1086
Query: 399 SNRKRVEELSLELSEALRKLENSDKEKRQLQKTVAEQDMKMNDMLDRIKHQHREQGSIKC 458
+ RVEE + + + AL+K+ + + +LQ+ + + N + + E ++K
Sbjct: 1087 AALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKT 1146
Query: 459 KLEEDLQE--ATKLLEDKREQ----LKKSKEHE-KLMEGELEALRQEFKKKDKTLKENSR 511
+LE+ L A + L KREQ LKK+ E E K E +++ +RQ+ + + L E
Sbjct: 1147 ELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLE 1206
Query: 512 KLEEENENLRAELQCCSTQLESSLNKYNTSQQVIQDLNKEIALQKESLMSLQAQLDKALQ 571
+ + NL Q + N+ Q D + + L LQ + ++ +
Sbjct: 1207 QTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEG-E 1265
Query: 572 KEKHYLQTTITKEAYDALSRKSAACQDDLTQALEKLNHVTSETKSLQQSLTQTQEKKAQL 631
+ + L +TK + + Q D K + +T + +L+ L TQE +
Sbjct: 1266 RVRTELADKVTKLQVELDNVTGLLSQSD-----SKSSKLTKDFSALESQLQDTQELLQEE 1320
Query: 632 EEEIIAYEERMKKLNTELRKLRGFHQESELEVHAFDKKLEEMSCQVLQWQKQHQNDLKML 691
+ ++ ++K++ E R +E E H +K++ + QV +K+ ++ + L
Sbjct: 1321 NRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCL 1380
Query: 692 AAKEEQLREFQEEMAALKENLLEDDKEPCCLPQWSVPKDTCRLYRGNDQIMTNLE---QW 748
EE R+ Q+++ L + E + K RL + D ++ +L+ Q
Sbjct: 1381 ETAEEVKRKLQKDLEGLSQR-----HEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQS 1435
Query: 749 AKQQKVANEKLGNQLREQVKYIAKLSGEKDREPTRASSPNTTRPS-SPSHSHLHSVMVHL 807
A + +K L E+ AK + E+DR A T S + + L
Sbjct: 1436 ACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAEL 1495
Query: 808 QQENKKLKKEIEE 820
++ NK+ + E+E+
Sbjct: 1496 ERLNKQFRTEMED 1508
Score = 125 bits (315), Expect = 1e-28
Identities = 163/799 (20%), Positives = 345/799 (43%), Gaps = 97/799 (12%)
Query: 89 EHQETQKRLSEVWQKVSQQDDLIQELRNKLACSNALVLEREKALIKLQADFASCTATHR- 147
E ++ Q+ + E+ +++ +++ Q+L+ + + A + + E+ I L+ +
Sbjct: 937 EKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKL 996
Query: 148 -------YPPSSSEECEDIKKILKHLQEQKDSQCLHVEEYQNLVKDLRVELEAVSEQKRN 200
+ + +EE E+ K L L+ + ++ +EE + R ELE +
Sbjct: 997 LEDRIAEFTTNLTEE-EEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEG 1055
Query: 201 IMKDMMKLELDLHGLREETSAHIERKDKDITILQCRLQELQLEFTETQKLTLKKDKFLQE 260
D+ +L E + +K++++ R++E + + + LKK ++E
Sbjct: 1056 DSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQ----KNMALKK---IRE 1108
Query: 261 KDEMLQELEKKLTQVQNSLLKKEKEL----EKQQCMATELEMTV------KEAKQDKSKE 310
+ + EL++ L + S K EK+ E+ + + TELE T+ +E + + +E
Sbjct: 1109 LESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQE 1168
Query: 311 AEC--KALQAEVQKLKNSLEEAKQQERLAAQQAAQCKEEAALAGCHLEDTQRKL--QKGL 366
K L+ E + + ++E +Q+ A ++ A+ E+ +LE ++ L ++G
Sbjct: 1169 VNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGE 1228
Query: 367 LLDKQKA---------DTIQELQRELQMLQKESSMAEKEQTSNRKRVEELSLELSEALRK 417
L ++ K ++++ +LQ LQ + + E+ +T +V +L +EL
Sbjct: 1229 LANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGL 1288
Query: 418 LENSDKEKRQLQKTVAEQDMKMNDMLDRIKHQHREQGSIKCKLEEDLQEATKLLEDKREQ 477
L SD + +L K + + ++ D + ++ ++R++ S+ KL++ E REQ
Sbjct: 1289 LSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSF----REQ 1344
Query: 478 LKKSKEHEKLMEGELEALRQEFKKKDKTLKENSRKL---EEENENLRAELQCCSTQLESS 534
L++ +E + +E ++ L + K ++++ L EE L+ +L+ S + E
Sbjct: 1345 LEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEK 1404
Query: 535 LNKYN-------TSQQVIQDLNKEIALQKESLMSL---QAQLDKALQKEKHYLQTTITKE 584
+ Y+ QQ + DL ++ Q++S +L Q + D+ L +EK TI+ +
Sbjct: 1405 VAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEK-----TISAK 1459
Query: 585 AYDALSRKSAACQDDLTQALEKLNHVTSETKSLQQSLTQTQEKKAQLEEEIIAYEERMKK 644
+ R A ++ T+AL SL ++L + E+KA+L E K+
Sbjct: 1460 YAEERDRAEAEAREKETKAL-----------SLARALEEAMEQKAEL-------ERLNKQ 1501
Query: 645 LNTELRKLRGFHQESELEVHAFDKKLEEMSCQVLQWQKQHQNDLKMLAAKEEQLREFQEE 704
TE+ L + VH +K + QV + + Q + L A E+ +
Sbjct: 1502 FRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVN 1561
Query: 705 MAALKENLLEDDKEPCCLPQWSVPKDTCRLYRGNDQIMTNLEQWAKQQKV---ANEKLGN 761
+ A+K D + + S K +L R ++ LE KQ+ + A +KL
Sbjct: 1562 LQAMKAQFERDLQG---RDEQSEEKKK-QLVRQVREMEAELEDERKQRSMAVAARKKLEM 1617
Query: 762 QLREQVKYIAKLSGEKDR-----EPTRASSPNTTRPSSPSHSHLHSVMVHLQQENKKLKK 816
L++ +I + +D +A + R + + ++ ++ KKLK
Sbjct: 1618 DLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKS 1677
Query: 817 ------EIEEKKMKAENTR 829
+++E+ AE +
Sbjct: 1678 MEAEMIQLQEELAAAERAK 1696
Score = 109 bits (273), Expect = 1e-23
Identities = 165/815 (20%), Positives = 347/815 (42%), Gaps = 97/815 (11%)
Query: 15 AQEQLALAGDKIASLERSLNLYRDKYQSSLSNIELLECQVKMLQGELGGIMGQEPENKGD 74
AQ+ +AL KI LE ++ ++ +S ++ E Q + L EL + E E+ D
Sbjct: 1097 AQKNMALK--KIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALK-TELEDTLD 1153
Query: 75 HSKVRIYTSPCMIQEHQETQKRLSEVWQKVSQQDDLIQELRNKLACSNALVLEREKALIK 134
+ + QE +K L E + + IQE+R K + + + E+ + +
Sbjct: 1154 STAAQQELRSKREQEVNILKKTLEE---EAKTHEAQIQEMRQKHSQAVEELAEQLEQTKR 1210
Query: 135 LQADFASCTATHRYPPSSSEECEDIKKILKHLQEQKDSQCLHVEEYQNLVKDLRVELEAV 194
++A+ T +E E ++ LQ + DS+ ++ + +++L+V+
Sbjct: 1211 VKANLEKAKQT-----LENERGELANEVKVLLQGKGDSEHKR-KKVEAQLQELQVKFNEG 1264
Query: 195 SEQKRNIMKDMMKLELDLH---GLREETSAHIERKDKDITILQCRLQELQ--LEFTETQK 249
+ + + KL+++L GL ++ + + KD + L+ +LQ+ Q L+ QK
Sbjct: 1265 ERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQK 1324
Query: 250 LTL---------KKDKF---LQEKDEMLQELEKKLTQVQNSLLKKEKELEKQQ-CMATEL 296
L+L +K+ F L+E++E LEK++ + + +K++E C+ T
Sbjct: 1325 LSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLET-- 1382
Query: 297 EMTVKEAKQDKSKEAECKALQAEVQKLK-NSLEEAKQQERLAAQQAAQCKEEAALAGCHL 355
+E K+ K+ E + + E + + LE+ K + + + + C+L
Sbjct: 1383 ---AEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNL 1439
Query: 356 EDTQRKLQKGLLLDK------------------QKADTIQELQRELQMLQKESSMAEKEQ 397
E Q+K + L +K +K L R L+ ++ + E+
Sbjct: 1440 EKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLN 1499
Query: 398 TSNRKRVEELSLELSEALRKLENSDKEKRQLQKTVAEQDMKMNDMLDRIKHQHREQ---- 453
R +E+L + + + +K KR L++ V E ++ ++ D ++ +
Sbjct: 1500 KQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLE 1559
Query: 454 ---GSIKCKLEEDLQEATKLLEDKREQLKKSKEHEKLMEGELEALRQE-------FKKKD 503
++K + E DLQ + E+K++QL + ME ELE R++ KK +
Sbjct: 1560 VNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVRE---MEAELEDERKQRSMAVAARKKLE 1616
Query: 504 KTLKENSRKLEEENEN----------LRAELQCCSTQLESSLNKYNTSQQVIQDLNKEIA 553
LK+ ++ N+N L+A+++ C +L+ + ++ K++
Sbjct: 1617 MDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLK 1676
Query: 554 LQKESLMSLQAQLDKALQKEKHYLQTTITKEAYDALSRKSAACQDDLTQALEKLNHVTSE 613
+ ++ LQ +L A + ++ ++ D L+ + A ALE+ + +
Sbjct: 1677 SMEAEMIQLQEELAAAERAKRQ------AQQERDELADEIANSSGKGALALEEKRRLEAR 1730
Query: 614 TKSLQQSLTQTQEKKAQLEEEIIAYEERMKKLNTELRKLRGFHQESELEVHAFDKKLEEM 673
L++ L + Q + + + ++ ++NT+L R Q++E +++ +E+
Sbjct: 1731 IAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKEL 1790
Query: 674 SCQVLQWQ----KQHQNDLKMLAAK----EEQL-REFQEEMAALKENLLEDDKEPCCLPQ 724
++ + + +++ + L AK EEQL E +E AA K+ + K L Q
Sbjct: 1791 KVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQ 1850
Query: 725 WSVPKDTCRLYRGN-DQIMTNLEQWAKQQKVANEK 758
+ Y+ D+ T L+Q +Q + A E+
Sbjct: 1851 VDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEE 1885
Score = 90.9 bits (224), Expect = 5e-18
Identities = 148/725 (20%), Positives = 298/725 (41%), Gaps = 142/725 (19%)
Query: 240 LQLEFTETQKLTLKKDKFLQ--EKDEMLQELEKKLTQVQNSLLKKEKELEKQQCMATELE 297
L+L + +L K LQ ++E + E++L +V+ L E L + + + ++L
Sbjct: 820 LKLRNWQWWRLFTKVKPLLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLM 879
Query: 298 MTVKEAKQDKSKEAECKALQAEVQKLKNSLEEAKQQ-ERLAAQQAAQCKEEAALAGCHLE 356
+ ++ E E L AE ++L+ L KQ+ E + A+ +EE HL+
Sbjct: 880 AEKLQLQEQLQAETE---LCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQ-HLQ 935
Query: 357 DTQRKLQKGLLLDKQKADTIQELQRELQMLQKESSMAEKEQTSNRKRVEELSLELSEALR 416
++K+Q+ IQEL+ +L+ E+ S R++++ + L+
Sbjct: 936 AEKKKMQQN----------IQELEEQLE-----------EEESARQKLQLEKVTTEAKLK 974
Query: 417 KLENSD-----------KEKRQLQKTVAE------QDMKMNDMLDRIKHQHREQGSIKCK 459
KLE KEK+ L+ +AE ++ + + L ++K++H
Sbjct: 975 KLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHE-------A 1027
Query: 460 LEEDLQEATKLLEDKREQLKKSK-----------EHEKLMEGELEALRQEFKKKDKTLKE 508
+ DL+E + E +R++L+K++ + ++ ++ L+ + KK++ L+
Sbjct: 1028 MITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQA 1087
Query: 509 NSRKLEEEN----------ENLRAELQCCSTQLESSLNKYNTSQQVIQDLNKEIALQKES 558
++EEE L +++ LES N +++ +DL +E+ K
Sbjct: 1088 ALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTE 1147
Query: 559 L------MSLQAQLDKALQKEKHYLQTTITKEA------YDALSRKSAACQDDLTQALEK 606
L + Q +L ++E + L+ T+ +EA + +K + ++L + LE+
Sbjct: 1148 LEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQ 1207
Query: 607 LNHV------------------TSETKSLQQSLTQTQEKK----AQLEEEIIAYEE---- 640
V +E K L Q ++ K+ AQL+E + + E
Sbjct: 1208 TKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERV 1267
Query: 641 ------RMKKLNTELRKLRGFHQESELEVHAFDKKLEEMSCQVLQWQKQHQNDLKMLAAK 694
++ KL EL + G +S+ + K + Q+ Q+ Q + + +
Sbjct: 1268 RTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSL 1327
Query: 695 EEQLREFQEEMAALKENLLEDDKEPCCLPQWSVPKDTCRLYRGNDQIMTNLEQWAKQQKV 754
+L++ ++E + +E L E+++ L + QI T Q A +K
Sbjct: 1328 STKLKQVEDEKNSFREQLEEEEEAKHNLEK---------------QIATLHAQVADMKKK 1372
Query: 755 ANEKLG-NQLREQVKYIAK--LSGEKDR-EPTRASSPNTTRPSSPSHSHLHSVMVHLQQE 810
+ +G + E+VK + L G R E A+ + + L ++V L +
Sbjct: 1373 MEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQ 1432
Query: 811 NKKL----KKEIEEKKMKAENTRLCTK-ALGPSRTESTQREKVCGTLGW-KGLPQDMGQR 864
+ KK+ + ++ AE + K A R E+ REK L + L + M Q+
Sbjct: 1433 RQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQK 1492
Query: 865 MDLTK 869
+L +
Sbjct: 1493 AELER 1497
Score = 87.0 bits (214), Expect = 7e-17
Identities = 130/590 (22%), Positives = 258/590 (43%), Gaps = 99/590 (16%)
Query: 6 ENTGEKLHLAQEQLALAGDKIASLERSLNLYRDKYQSSLSNIELLECQVKMLQGELGGIM 65
E E H ++Q+A ++A +++ K + S+ +E E + LQ +L G+
Sbjct: 1346 EEEEEAKHNLEKQIATLHAQVADMKK-------KMEDSVGCLETAEEVKRKLQKDLEGLS 1398
Query: 66 GQEPE-----NKGDHSKVRIYT--------------SPCMIQEHQETQKRLSEVWQKVS- 105
+ E +K + +K R+ S C +++ Q+ +L + +S
Sbjct: 1399 QRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISA 1458
Query: 106 ----QQDDLIQELRNK----LACSNAL--VLEREKALIKLQADFASCTATHRYPPSSSEE 155
++D E R K L+ + AL +E++ L +L F T SS++
Sbjct: 1459 KYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFR----TEMEDLMSSKD 1514
Query: 156 CEDIKKILKHLQEQKDSQCLHVEEYQNLVKDLRVELEAVSEQKR----NIMKDMMKLELD 211
D+ K + L++ K + VEE + +++L EL+A + K N+ + E D
Sbjct: 1515 --DVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERD 1572
Query: 212 LHGLREETSAHIERKDKDITILQCRLQELQLEFTETQK----------------LTLKKD 255
L G E++ E K K + + Q R E +LE Q+ L D
Sbjct: 1573 LQGRDEQS----EEKKKQL-VRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHID 1627
Query: 256 KFLQEKDEMLQELEKKLTQVQNSLLKKEKELEKQQCMATELEMTVKE-AKQDKSKEAECK 314
+ +DE +++L K Q+++ + +EL+ + E+ KE K+ KS EAE
Sbjct: 1628 SANKNRDEAIKQLRKLQAQMKDCM----RELDDTRASREEILAQAKENEKKLKSMEAEMI 1683
Query: 315 ALQAEVQKLKNSLEEAKQQERLAAQQAAQCKEEAALAGCHLEDTQR------KLQKGLLL 368
LQ E+ + + +A+Q+ A + A + ALA LE+ +R +L++ L
Sbjct: 1684 QLQEELAAAERAKRQAQQERDELADEIANSSGKGALA---LEEKRRLEARIAQLEEELEE 1740
Query: 369 DKQKADTIQELQRELQM--------LQKESSMAEKEQTSNRKRVEELSLELSEALRKLEN 420
++ + I + ++ + L E S A+K + + R+++E + EL L+++E
Sbjct: 1741 EQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENA-RQQLERQNKELKVKLQEMEG 1799
Query: 421 SDKEKRQLQKTVAEQDM-KMNDMLDRIKHQHREQGSIKCKLEEDLQEATKLLEDKR---- 475
+ K K + T E + ++ + LD + + + E+ L++ ++D+R
Sbjct: 1800 TVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAE 1859
Query: 476 ---EQLKKSKEHEKLMEGELEALRQEFKKKDKTLKENSRKLEEENENLRA 522
+Q K+ K ++ +LE +E ++ + + ++ R+LE+ E A
Sbjct: 1860 QYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETADA 1909
Score = 66.6 bits (161), Expect = 1e-10
Identities = 84/423 (19%), Positives = 187/423 (44%), Gaps = 77/423 (18%)
Query: 92 ETQKRLSEVWQKVSQQDDLIQELRNKLACSNALVLEREKALIKLQADFASCTATHRYPPS 151
E +K + Q+V + ++EL ++L + L E L ++A F R
Sbjct: 1522 ELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQF------ERDLQG 1575
Query: 152 SSEECEDIKKIL--------KHLQEQKDSQCLHVEEYQNL---VKDLRVELEAVSEQKRN 200
E+ E+ KK L L++++ + + V + L +KDL +++ ++ +
Sbjct: 1576 RDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDE 1635
Query: 201 IMKDMMKLEL----------DLHGLREETSAHIERKDKDITILQCRLQELQLEFTETQKL 250
+K + KL+ D REE A + +K + ++ + +LQ E ++
Sbjct: 1636 AIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERA 1695
Query: 251 TLKKDKFLQEKDEMLQE-----------LEKKLTQVQNSLLKKEKELEKQQC-------- 291
K + QE+DE+ E LE+K +++ + + E+ELE++Q
Sbjct: 1696 ---KRQAQQERDELADEIANSSGKGALALEEK-RRLEARIAQLEEELEEEQGNTELINDR 1751
Query: 292 ----------MATELEMTVKEAKQDKSK----EAECKALQAEVQKLKNSLEEAKQQERLA 337
+ T+L + A+++++ E + K L+ ++Q+++ +++ +K + +
Sbjct: 1752 LKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVK-SKYKASIT 1810
Query: 338 AQQAAQCKEEAALAGCHLEDTQRKLQKGLLLDKQKADTIQELQRELQMLQKESSMAEKEQ 397
A +A + E L ++ Q ++ +K+ D + ++ E + ++ A+K
Sbjct: 1811 ALEAKIAQLEEQLDN-ETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKAS 1869
Query: 398 TSNRKRVEELSLELSEALRKLENSDKEKRQLQKTVAEQDMKMNDMLDRIKHQHREQGSIK 457
T R+++L +L EA + + ++ +R+LQ+ ++ D + +RE S+K
Sbjct: 1870 T----RLKQLKRQLEEAEEEAQRANASRRKLQR-------ELEDATETADAMNREVSSLK 1918
Query: 458 CKL 460
KL
Sbjct: 1919 NKL 1921
Score = 43.5 bits (101), Expect = 9e-04
Identities = 68/373 (18%), Positives = 145/373 (38%), Gaps = 56/373 (15%)
Query: 25 KIASLERSLNLYRDKYQSSLSNIELLECQVKMLQGELGGIMGQEPENKGDHSKVRIYTSP 84
++ +E L R + +++ + LE +K L+ + E K++
Sbjct: 1590 QVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKD 1649
Query: 85 CMIQEHQETQKRLSEVWQKVSQQDDLIQELRNKLACSNALVLEREKALIKLQADFASCTA 144
CM +E +T+ E+ + + + ++ + E +I+LQ + A+
Sbjct: 1650 CM-RELDDTRASREEILAQAKENEKKLKSM--------------EAEMIQLQEELAAAER 1694
Query: 145 THRYPPSSSEECEDIKKILKHLQEQKDSQCLHVEEYQNL---VKDLRVELEAVSE----- 196
R +E D + L +EE + L + L ELE
Sbjct: 1695 AKRQAQQERDELAD------EIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELI 1748
Query: 197 ----QKRNIMKDMMKLELDL---HGLREETSAH-IERKDKDITILQCRLQELQLEFTETQ 248
+K N+ D + +L+L H + E + +ER++K++ + +LQE++
Sbjct: 1749 NDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKV---KLQEMEGTVKSKY 1805
Query: 249 K--LTLKKDKFLQEKDEM-------------LQELEKKLTQVQNSLLKKEKELEKQQCMA 293
K +T + K Q ++++ ++ EKKL V + + + E+ + A
Sbjct: 1806 KASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQA 1865
Query: 294 TELEMTVKEAKQD-KSKEAECKALQAEVQKLKNSLEEAKQQERLAAQQAAQCKEEAALAG 352
+ +K+ K+ + E E + A +KL+ LE+A + ++ + K +
Sbjct: 1866 DKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETADAMNREVSSLKNKLRRGD 1925
Query: 353 CHLEDTQRKLQKG 365
+R +KG
Sbjct: 1926 LPFVVPRRMARKG 1938
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 128 bits (321), Expect = 3e-29
Identities = 191/863 (22%), Positives = 387/863 (44%), Gaps = 133/863 (15%)
Query: 16 QEQLALAGDKIASLERSLNLYRDKYQSSLSNIELL---ECQVKMLQGELGGIMGQEPENK 72
+EQL + ++ER L +K Q +L ++ L + +K LQ L + +
Sbjct: 893 KEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESL--------QIE 944
Query: 73 GDHSKVRIYTSPCMIQEHQETQKRLSEVWQKVSQQDDLIQELRNKLACSNALVLEREKAL 132
D K I+ + + + +TQ++L + + Q + I L++K++ + L E+
Sbjct: 945 RDQLKSDIHDT---VNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENT 1001
Query: 133 IKLQADF--------------ASCTATHRYPPSSSEECEDIKKILKHLQEQKDSQCL--- 175
+ + +F A T T +E E +KI +QE+ + Q +
Sbjct: 1002 GETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLES 1061
Query: 176 HVEEYQNLVKDLR--VELEAVSEQKRNIMKDMMKLELDLHGLREETSAHIERKDKDITIL 233
+ E + L DL+ +E+ ++++ ++ D +K + ++ + H +K+ +++
Sbjct: 1062 VIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVA---QEKNHAIKKEGELSRT 1118
Query: 234 QCRLQELQLEFTE-TQKLTLKKDKFLQEKDEMLQELEKKLTQVQ---NSLLKKEKELEKQ 289
RL E++ + E +Q+L K+ + L ++EM E++KK+ +++ N L KE LE
Sbjct: 1119 CDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEM-SEMQKKINEIENLKNELKNKELTLEHM 1177
Query: 290 QCMATELEMTVKEAKQD-KSKEAECKALQAEVQKLKNSLEEAKQQERLAAQQAAQCKEEA 348
+ EL + E ++ KS E K L+ + + + + R Q KEE
Sbjct: 1178 ETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEEL 1237
Query: 349 ALAGCHLEDTQRKLQKGLLLDKQKADTIQELQRELQMLQKESSMAEK-EQTSNRKRVEEL 407
+A HL++ Q +TI EL+R S++EK Q N + +E+
Sbjct: 1238 KIAHIHLKEHQ--------------ETIDELRR---------SVSEKTAQIINTQDLEKS 1274
Query: 408 SLELSEALRKLENSDKEKRQLQKTVAEQDMKMNDMLDRIKHQHREQGSIKCKLEEDLQEA 467
+L E + L + ++E K V+E MN++ + + + ++E +
Sbjct: 1275 HTKLQEEIPVL-HEEQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRL 1333
Query: 468 TKLLEDKREQLKK-SKEHEKLMEGELEALRQEFKKKDKTLKENSRKLEEENENLRAELQC 526
+ ++ +E++K +KE + L+ +++ + K LKE+ R+ A++Q
Sbjct: 1334 NEKFQESQEEIKSLTKERD-----NLKTIKEALEVKHDQLKEHIRE-------TLAKIQE 1381
Query: 527 CSTQLESSLN---KYNTSQQVIQDLNKEIALQKESLMSLQAQ---LDKALQKEKHYLQTT 580
++ E SLN K N + +++ ++ ++ + +L+ ++ + L K LQ E H +
Sbjct: 1382 SQSKQEQSLNMKEKDNETTKIVSEM-EQFKPKDSALLRIEIEMLGLSKRLQ-ESHDEMKS 1439
Query: 581 ITKEAYDALSRKSAACQDDLTQALEKLNHVTSETKSLQQSLTQTQEKKAQLEEEIIAYEE 640
+ KE +DDL + E L SE+ L++++ + K + EEE+
Sbjct: 1440 VAKE------------KDDLQRLQEVLQ---SESDQLKENIKEIVAKHLETEEELKVAHC 1484
Query: 641 RMKKLNTELRKLRGFHQESELEVHAFDKKLEEMSCQVLQ-----WQKQHQNDLKMLAAKE 695
+K+ + +LR E E E+ K+LE ++ ++ ++K+ Q ++K ++ +
Sbjct: 1485 CLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQ 1544
Query: 696 E---QLREFQEEMAALKENLLEDDKEPCCLPQWSVPKDTCRLYRGND--QIMTNLEQWAK 750
E +L++F+E A K++ L+ + + + T RL + QIM ++ K
Sbjct: 1545 EKVNELKQFKEHRKA-KDSALQSIES-------KMLELTNRLQESQEEIQIMIKEKEEMK 1596
Query: 751 QQKVANEKLGNQLREQVKYIA---KLSGEKDREPTRASSPNTTRPSSPSHSHLHSVMVHL 807
+ + A + +QL+E K I K S EK+ + + ++ N T+ HL
Sbjct: 1597 RVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKE----- 1651
Query: 808 QQENKKLKKEIEEKKMKAENTRL 830
Q E +KL E ++ EN RL
Sbjct: 1652 QFETQKLNLE----NIETENIRL 1670
Score = 112 bits (281), Expect = 1e-24
Identities = 183/883 (20%), Positives = 369/883 (41%), Gaps = 121/883 (13%)
Query: 11 KLHLAQEQLALA---GDKIASLERSLNLYRDKYQSSLSNI--ELLECQVKMLQGELGGIM 65
+L +QE++ + +++ ++ +L + RD+ + + I ++ E Q K Q +
Sbjct: 1577 RLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAV 1636
Query: 66 GQEPEN--KGDHSKVRIYTSPCMIQEHQETQKRLSEVWQKVSQQDDLIQELRNKL-ACSN 122
+ E + +H K + T ++ + RL+++ + ++ + + R+ L +
Sbjct: 1637 NETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEE 1696
Query: 123 ALVLEREKALIKLQADFASCTATHRYPPSSSEECEDIKKILKHLQEQKDS-------QCL 175
L +ER++ L+ E+ E++K + HL+E +++
Sbjct: 1697 TLKVERDQLKENLRETITR----------DLEKQEELKIVHMHLKEHQETIDKLRGIVSE 1746
Query: 176 HVEEYQNLVKDLRVELEAVSEQKRNIMKDMMKLELDL----------HGLREETSAHIER 225
E N+ KDL +A+ Q I +++ + L G+ E + +
Sbjct: 1747 KTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSN 1806
Query: 226 KDKDITILQCRLQEL--QLEFTETQKLTLKKDKFLQEKDEMLQELEKKLTQVQNSLLKKE 283
KD+ +LQE +L+ E Q +TLKKD + E + + E+E+ Q+++ L
Sbjct: 1807 MQKDLENSNAKLQEKIQELKANEHQLITLKKD--VNETQKKVSEMEQLKKQIKDQSLTLS 1864
Query: 284 KELEKQQCMATELEMTVKEAK-----QDKSKEAECKALQAEVQKLKNSLEEAKQQERLAA 338
K + +A +L ++E K +D + E + L+ E +LK SL+E K ++ L
Sbjct: 1865 KLEIENLNLAQKLHENLEEMKSVMKERDNLRRVE-ETLKLERDQLKESLQETKARD-LEI 1922
Query: 339 QQAAQCKEEAALAGCHLEDTQRKLQKGLLLDKQKADTIQELQRELQMLQKESSMAEKEQT 398
QQ + K L+ H E + +K +K I ++Q++L + E + +K Q
Sbjct: 1923 QQ--ELKTARMLSKEHKETVDKLREK----ISEKTIQISDIQKDLDKSKDE--LQKKIQE 1974
Query: 399 SNRKRVEELSLELSEALRKLENSDKEKRQLQKTVAEQDMKMNDMLDRIKHQHREQGSIKC 458
+K ++ L + E + E QL+K Q++ M + + +
Sbjct: 1975 LQKKELQ--LLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSV-------RMDNFQLTK 2025
Query: 459 KLEEDLQEATKLLEDKREQLKKSKEHEKLMEGELEALRQEFKKKDKT---LKENSRKLEE 515
KL E L+E +++ +R++L++ KE K+ + A +E +D+ +K R L +
Sbjct: 2026 KLHESLEEI-RIVAKERDELRRIKESLKMERDQFIATLREMIARDRQNHQVKPEKRLLSD 2084
Query: 516 ENENLRAELQCCSTQLESSLNKYNTSQQVIQ-------DLNKEIALQKESLMSLQAQLDK 568
++L L+ ++++ L +Y+ + DL KEI QKE M ++A L
Sbjct: 2085 GQQHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKEIEFQKELSMRVKANLSL 2144
Query: 569 ALQKEKHYLQTTITKEAYDALSRKSAACQDDLTQALEKLNHVTSETKSLQQSLTQTQEKK 628
YLQT ++ + A R C + + ++KL +V S +++ + E
Sbjct: 2145 P------YLQTKHIEKLFTANQR----CSMEFHRIMKKLKYVLSYVTKIKE---EQHESI 2191
Query: 629 AQLEEEIIAYEERMKKL--------------NTELRKLRGFHQESELEVHAFDKKLEEMS 674
+ E + I E+ K+L + ELR L+ +Q +L + K E
Sbjct: 2192 NKFEMDFIDEVEKQKELLIKIQHLQQDCDVPSRELRDLK-LNQNMDLHIEEILKDFSESE 2250
Query: 675 CQVL--QWQKQHQNDLKMLAAKEEQLREFQEEMAALKENLLEDDKEPCCLPQW------S 726
+ ++Q+ N +M EE L + ++ LK + +++ C + + +
Sbjct: 2251 FPSIKTEFQQVLSNRKEMTQFLEEWLNT-RFDIEKLKNGIQKENDRICQVNNFFNNRIIA 2309
Query: 727 VPKDTCRLYRGNDQIMTNLEQWAKQQKVANEKLGNQLREQVKYIAK-------LSGEKDR 779
+ ++ + I EQ K K NEKL + +A K+
Sbjct: 2310 IMNESTEFEERSATISKEWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQDNKNP 2369
Query: 780 EPTRASSPNTTRPSSPSHSHLHSV---MVHLQQENKKLKKEIE 819
T ++ TT + LH +H + + K++KE+E
Sbjct: 2370 HVTSRATQLTTEKIRELENSLHEAKESAMHKESKIIKMQKELE 2412
Score = 112 bits (279), Expect = 2e-24
Identities = 169/820 (20%), Positives = 356/820 (43%), Gaps = 119/820 (14%)
Query: 87 IQEHQE----TQKRLSEVWQKVSQQDDLIQELRNKLACSNALVLEREKALIKLQADFASC 142
+QE Q+ Q+ +SE+ +K+++ ++L EL+NK + ER + KL ++
Sbjct: 1136 LQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEV 1195
Query: 143 TATHR-------YPPSSSEECEDIKKILKHLQ-------EQKDSQCLHVEEYQNLVKDLR 188
+ + S E + ++ ++ ++ E+ +H++E+Q + +LR
Sbjct: 1196 KSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELR 1255
Query: 189 VELEAVSEQ---KRNIMKDMMKLELDLHGLREETSAHIERKD------------------ 227
+ + Q +++ K KL+ ++ L EE K+
Sbjct: 1256 RSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQS 1315
Query: 228 --KDITIL-QCRLQELQL--EFTETQK----LTLKKD--KFLQE-----KDEMLQELEKK 271
KD T L + ++ L+L +F E+Q+ LT ++D K ++E D++ + + +
Sbjct: 1316 TTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRET 1375
Query: 272 LTQVQNSLLKKEKELEKQQCMATELEMTVKEAKQDKSKEAECKALQAEVQKLKNSLEEAK 331
L ++Q S K+E+ L ++ E V E +Q K K++ ++ E+ L L+E+
Sbjct: 1376 LAKIQESQSKQEQSLNMKE-KDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESH 1434
Query: 332 QQERLAAQ--------------QAAQCKEE-AALAGCHLEDTQRKLQKGLLLDKQKADTI 376
+ + A+ ++ Q KE + HLE T+ +L+ K++ +TI
Sbjct: 1435 DEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLE-TEEELKVAHCCLKEQEETI 1493
Query: 377 QELQRELQMLQKESSMAEKEQTSNRKRVEELSLELSEALRKLENSDKEKRQLQKTVAEQD 436
EL+ L S E E ++ +K++E ++ +L ++++ +KE++ K ++E
Sbjct: 1494 NELRVNL-------SEKETEISTIQKQLEAINDKLQNKIQEI--YEKEEQFNIKQISEVQ 1544
Query: 437 MKMNDMLDRIKHQHREQGSIKCKLEEDLQEATKLLEDKREQLKKSKEHEKLMEGELEALR 496
K+N+ L + K + + S +E + E T L++ +E+++ + ++ M+ EAL+
Sbjct: 1545 EKVNE-LKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQ 1603
Query: 497 QEFKKKDKTLKENSRKLEEENENLRAELQCCSTQLESSLNKYNTSQQVIQDLNKEIALQK 556
E + + KE K++E E L+ +++N+ I+ L ++ QK
Sbjct: 1604 IERDQLKENTKEIVAKMKESQEKEYQFLKM------TAVNETQEKMCEIEHLKEQFETQK 1657
Query: 557 ESLMSLQAQLDKALQKEKHYLQ--TTITKEAYDALSRKSAACQDDLTQALEKLNHVTSET 614
+L +++ + + Q L+ ++TKE +DDL E L E
Sbjct: 1658 LNLENIETENIRLTQILHENLEEMRSVTKE------------RDDLRSVEETLK---VER 1702
Query: 615 KSLQQSLTQTQEKKAQLEEEIIAYEERMKKLNTELRKLRGFHQESELEVHAFDKKLEEMS 674
L+++L +T + + +EE+ +K+ + KLRG E E+ K LE +
Sbjct: 1703 DQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSN 1762
Query: 675 CQVLQWQKQHQNDLKMLAAKEEQLREFQEEMAALKENLLEDDKEPCCLPQWSVPKDTCRL 734
+ + Q +L++ L+E QE + L+ ++ + + Q + +L
Sbjct: 1763 DALKAQDLKIQEELRI---AHMHLKEQQETIDKLR-GIVSEKTDKLSNMQKDLENSNAKL 1818
Query: 735 YRGNDQIMTNLEQWAKQQKVAN---------EKLGNQLREQVKYIAKLSGEK-DREPTRA 784
++ N Q +K N E+L Q+++Q ++KL E +
Sbjct: 1819 QEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLH 1878
Query: 785 SSPNTTRPSSPSHSHLHSVMVHLQQENKKLKKEIEEKKMK 824
+ + +L V L+ E +LK+ ++E K +
Sbjct: 1879 ENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKAR 1918
Score = 111 bits (277), Expect = 3e-24
Identities = 169/800 (21%), Positives = 345/800 (43%), Gaps = 118/800 (14%)
Query: 3 NHNENTGEKLHLAQEQLALAGDK-IASLERSLNLYRDKYQSSLSNIELLECQVKMLQGEL 61
+ + T +L L EQ +A +E +K+Q S I+ L + L+
Sbjct: 1299 SETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLK--- 1355
Query: 62 GGIMGQEPENKGDHSKVRIYTSPCMIQEHQETQKRLSEVWQKVSQQDDLIQELRNKLACS 121
+ + E K D K I + IQE Q Q++ + +K ++ ++ E+
Sbjct: 1356 --TIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQ----- 1408
Query: 122 NALVLEREKALIKLQADFASCTA----THRYPPSSSEECEDIKK---------------- 161
++ AL++++ + + +H S ++E +D+++
Sbjct: 1409 ---FKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENI 1465
Query: 162 ---ILKHLQEQKDSQCLH--VEEYQNLVKDLRVELEAVSEQKRNIMKDMMKLELDLHGLR 216
+ KHL+ +++ + H ++E + + +LRV L + I K + + L
Sbjct: 1466 KEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKI 1525
Query: 217 EETSAHIERKD-KDITILQCRLQELQLEFTETQKLTLKKDKFLQEKDEMLQELEKKLTQV 275
+E E+ + K I+ +Q ++ EL+ +F E +K KD LQ + + EL +L +
Sbjct: 1526 QEIYEKEEQFNIKQISEVQEKVNELK-QFKEHRKA---KDSALQSIESKMLELTNRLQES 1581
Query: 276 QNSL--LKKEKELEKQ-----QCMATELEMTVKE--AKQDKSKEAECKALQ--------- 317
Q + + KEKE K+ Q +L+ KE AK +S+E E + L+
Sbjct: 1582 QEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQE 1641
Query: 318 --AEVQKLKNSLEEAK------QQERLAAQQAAQCKEEAALAGCHLEDTQRKLQKGLLL- 368
E++ LK E K + E + Q E + D R +++ L +
Sbjct: 1642 KMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVE 1701
Query: 369 -DKQKADTIQELQRELQMLQKESSMAEKEQTSNRKRVEELSLELSEALRKLENSDKEKRQ 427
D+ K + + + R+L+ Q+E + +++ +++L +SE ++ N K+
Sbjct: 1702 RDQLKENLRETITRDLEK-QEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEH 1760
Query: 428 LQKTVAEQDMKMNDMLDRIKHQH-REQGSIKCKL--------------EEDLQEATKLLE 472
+ QD+K+ + L RI H H +EQ KL ++DL+ + L+
Sbjct: 1761 SNDALKAQDLKIQEEL-RIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQ 1819
Query: 473 DKREQLKKSKEHEKL-----------MEGELEALRQEFKKKDKTLKENSRKLEEENENLR 521
+K ++L K+ EH+ + E+E L+++ K + TL KLE EN NL
Sbjct: 1820 EKIQEL-KANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLS----KLEIENLNLA 1874
Query: 522 AELQCCSTQLESSLNKYNTSQQVIQDLNKEIALQKESLMSLQAQLDKALQKEKHYLQTTI 581
+L +++S + + + ++V + L E KESL +A+ D +Q+E L+T
Sbjct: 1875 QKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKAR-DLEIQQE---LKTA- 1929
Query: 582 TKEAYDALSRKSAACQDDLTQAL-EKLNHVTSETKSLQQSLTQTQEKKAQLEEEIIAYEE 640
LS++ D L + + EK ++ K L +S + Q+K +L+++ +
Sbjct: 1930 -----RMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLR 1984
Query: 641 RMKKLNTELRKLRGFHQ-ESELEVHAFDKKLEEM-SCQVLQWQKQHQNDLKMLAAKEEQL 698
+ +N +K+ Q + + E + M + Q+ + + +++++A + ++L
Sbjct: 1985 VKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDEL 2044
Query: 699 REFQEEMAALKENLLEDDKE 718
R +E + ++ + +E
Sbjct: 2045 RRIKESLKMERDQFIATLRE 2064
Score = 102 bits (255), Expect = 1e-21
Identities = 166/848 (19%), Positives = 343/848 (40%), Gaps = 119/848 (14%)
Query: 28 SLERSLNLYRDKYQSSLSNIELLECQVKMLQGELGGIMGQEPENKGDHSKVRIYTSPCMI 87
++E LN R Y + + + E L + + ++ +L + K D +
Sbjct: 495 NIESELNSLRADYDNLVLDYEQLRTEKEEMELKL--------KEKNDLDEFEALERKTKK 546
Query: 88 QEHQETQKRLSEVWQKVSQQDDLIQELRNKLACSNALVLEREKALIKLQADFASCTATHR 147
+ + +S + V + Q+L N+L+ L+ E+E + KLQ
Sbjct: 547 DQEMQLIHEISNLKNLVKHAEVYNQDLENELSSKVELLREKEDQIKKLQEYI-------- 598
Query: 148 YPPSSSEECEDIKKILKHLQEQKDSQCLHVEEYQNLVKDLRVELEAVSEQKRNIMKDMMK 207
S++ E+IK L + E +E+ + + + L + E V+ + +
Sbjct: 599 ----DSQKLENIKMDLSYSLES-------IEDPKQMKQTL-FDAETVALDAKRESAFLRS 646
Query: 208 LELDLHGLREETSAHIERKDKDITILQCRLQ-----------ELQLEFTETQKLTLKKDK 256
L+L +E + ++ + DI + Q +L+ ELQ F E KLT D
Sbjct: 647 ENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDG 706
Query: 257 FLQEKDEMLQELEKKLTQVQNSLLKKEKE---LEKQQCMATELEMTVKEA----KQDKSK 309
+ + ELE K+T +Q L K+ +E L ++ + +EL+ E K+ + K
Sbjct: 707 KVPKDLLCNLELEGKITDLQKELNKEVEENEALREEVILLSELKSLPSEVERLRKEIQDK 766
Query: 310 EAECKALQAEVQKLKNSLEEAKQQERLAAQQAAQCKEEAALAGCHLEDTQRKLQ--KGLL 367
E + +E KL + + + + + ++ + K++ A + + T ++ Q K L
Sbjct: 767 SEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLH 826
Query: 368 LD-----KQKADTIQELQRELQMLQKESSMAEKEQTSNRKRVEELSLELSEALRKLENSD 422
+D K + + + +E+ L KE+ + + + + + EL E R+++
Sbjct: 827 MDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERL 886
Query: 423 KEKRQLQKTVAEQDMKMNDMLDRIKHQHREQGSIKCKLEEDLQEATKLLEDKREQLKKSK 482
E QL++ + +D + + RE+ I KL++ L+E K L +++ LK+ +
Sbjct: 887 NEMEQLKEQLENRDSTLQTV-------EREKTLITEKLQQTLEE-VKTLTQEKDDLKQLQ 938
Query: 483 EHEKLMEGELEALRQEFKKKDKTLKENSRKLEEENENLRAELQCCSTQLESSLNKYNTSQ 542
E ++ E + L+ + + +L E+L+ + +T K S+
Sbjct: 939 ES---LQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTL------KSKISE 989
Query: 543 QVIQDLNKE--IALQKESLMSLQAQLDKALQKEKHYLQTTITKEAYDALSRKSAACQDDL 600
+V ++L+ E K+ +DK E Q T+T + D +++
Sbjct: 990 EVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQ-TLTADVKD----------NEI 1038
Query: 601 TQALEKLNHVTSETKSLQQSLTQTQEKKAQLEEEI-------IAYEERMKKLNTELRKLR 653
+ K+ + E LQQ L +K QL+ ++ I +E ++ L EL+K +
Sbjct: 1039 IEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQ 1098
Query: 654 GFHQESELEVHAFDKKLEEMSCQVLQWQKQHQNDLKMLAAKEEQLREFQEEMAALKENLL 713
+ + + +L ++ + +++ + + L K++QL QEEM+ +++ +
Sbjct: 1099 EIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKIN 1158
Query: 714 EDDKEPCCLPQWSVPKDTCRLYRGNDQIMTNLEQWAKQQKVANEKLGNQLREQVKYIAK- 772
E + L LE ++ +KL N+ E+VK I K
Sbjct: 1159 EIE----------------NLKNELKNKELTLEHMETERLELAQKL-NENYEEVKSITKE 1201
Query: 773 --------LSGEKDREPTRASSPNTTRPSSPSHSHLHSVMVHLQQENK---KLKKEIEEK 821
S E +R+ R + L +HL++ + +L++ + EK
Sbjct: 1202 RKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEK 1261
Query: 822 KMKAENTR 829
+ NT+
Sbjct: 1262 TAQIINTQ 1269
Score = 83.2 bits (204), Expect = 1e-15
Identities = 111/518 (21%), Positives = 221/518 (42%), Gaps = 62/518 (11%)
Query: 221 AHIERKDKDITILQCRLQELQLEFTETQKLTLKKDKFLQEKDEMLQELEKK--LTQVQNS 278
A ++R K+I L+ +L+E+ LE T Q + EKD++ Q LE+K L +VQN
Sbjct: 343 ALLKRYRKEIMDLKKQLEEVSLE-TRAQAM---------EKDQLAQLLEEKDLLQKVQN- 391
Query: 279 LLKKEKELEKQQCMATELEMTVKEAKQDKSKEAECKALQAEVQKLKNS---------LEE 329
EK + + T +T+++ + K K L ++ K+KNS
Sbjct: 392 ----EKIENLTRMLVTSSSLTLQQELKAKRKRRVTWCL-GKINKMKNSNYADQFNIPTNI 446
Query: 330 AKQQERLAAQQAAQCKEEAALAGCHLEDTQRKLQKGLLLDKQKADTIQELQRELQMLQKE 389
+ +L+ + E +T L + K + ++ EL L+ +
Sbjct: 447 TTKTHKLSINLLREIDESVCSESDVFSNTLDTLSEIEWNPATKLLNQENIESELNSLRAD 506
Query: 390 SSMAEKEQTSNRKRVEELSLELSEALRKLENSDKEKRQLQKTVAEQDMKMNDMLDRIKHQ 449
+ R EE+ L+L E + D+ + +KT +Q+M++ + +K+
Sbjct: 507 YDNLVLDYEQLRTEKEEMELKLKEK----NDLDEFEALERKTKKDQEMQLIHEISNLKNL 562
Query: 450 HREQGSIKCKLEEDLQEATKLLEDKREQLKKSKEH---EKL------MEGELEALRQEFK 500
+ LE +L +LL +K +Q+KK +E+ +KL + LE++ +
Sbjct: 563 VKHAEVYNQDLENELSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQ 622
Query: 501 KKDKTLKENSRKLEEENENLRAELQCCSTQLESSLNKYNTSQQVIQDLNKEIALQKESLM 560
K + L+ + E+ A L+ + +L+ + + T+ + +++ + Q E+
Sbjct: 623 MKQTLFDAETVALDAKRES--AFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKK 680
Query: 561 SLQAQLDKALQKEKHYLQTTITKEAYDALSRKSAACQDDLTQALEKLNHVTSETKSLQQS 620
+Q L+K LQ + + T D K C +L + LQ+
Sbjct: 681 KMQVDLEKELQSA--FNEITKLTSLIDGKVPKDLLCNLEL----------EGKITDLQKE 728
Query: 621 LTQTQEKKAQLEEEIIAYEERMKKLNTELRKLRGFHQESELEVHAFDKKLEEMSCQVLQW 680
L + E+ L EE+I E +K L +E+ +LR Q+ E+H + +++ +V+
Sbjct: 729 LNKEVEENEALREEVILLSE-LKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHK 787
Query: 681 QKQHQNDLKMLAAKEEQLREFQEEMAALKENLLEDDKE 718
+ + Q L E++ + ++++A + N D+E
Sbjct: 788 ESRVQGLL-------EEIGKTKDDLATTQSNYKSTDQE 818
Score = 67.8 bits (164), Expect = 4e-11
Identities = 136/714 (19%), Positives = 283/714 (39%), Gaps = 107/714 (14%)
Query: 1 MGNHNENTGEKLHLAQEQLALAGDKIASLERSLNLYRDKYQSSLSNIELLECQVKMLQGE 60
+ ++ T +KL +E+++ +I+ +++ L+ +D+ Q + ++ E Q+ ++ +
Sbjct: 1932 LSKEHKETVDKL---REKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKED 1988
Query: 61 LGGIMGQEPENKGDHSKVRIYTSPCMIQEHQETQKRLSEVWQKVSQQDDLIQELRNKLA- 119
+ M + N+ + K + +Q + +L++ + ++ ++ + R++L
Sbjct: 1989 VN--MSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDELRR 2046
Query: 120 CSNALVLEREKALIKLQADFASCTATHRYPP--------------SSSEECEDIKKILKH 165
+L +ER++ + L+ A H+ P S E+C IK++LK
Sbjct: 2047 IKESLKMERDQFIATLREMIARDRQNHQVKPEKRLLSDGQQHLTESLREKCSRIKELLKR 2106
Query: 166 LQEQKDSQCLHVEEYQNLVKDLRVELEAVSEQKRNIMKDMMKLELDLHGLREETSAH--- 222
E D H E L DL E+E E + ++ L + + +A+
Sbjct: 2107 YSEMDD----HYECLNRLSLDLEKEIEFQKELSMRVKANLSLPYLQTKHIEKLFTANQRC 2162
Query: 223 ------IERKDKDITILQCRLQELQ-----------LEFTETQKLTLKKDKFLQEKDEML 265
I +K K + +++E Q ++ E QK L K + LQ+ ++
Sbjct: 2163 SMEFHRIMKKLKYVLSYVTKIKEEQHESINKFEMDFIDEVEKQKELLIKIQHLQQDCDVP 2222
Query: 266 QELEKKLTQVQNSLLKKEKELE-----KQQCMATELEMTVKEAKQDKSKEAECKALQAEV 320
+ L QN L E+ L+ + + TE + + K+ E + ++
Sbjct: 2223 SRELRDLKLNQNMDLHIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDI 2282
Query: 321 QKLKNSLEEAKQQ---------ERLAA--QQAAQCKEEAALAGCHLEDTQRKLQKGLLLD 369
+KLKN +++ + R+ A ++ + +E +A E + L
Sbjct: 2283 EKLKNGIQKENDRICQVNNFFNNRIIAIMNESTEFEERSATISKEWEQDLKSL------- 2335
Query: 370 KQKADTIQELQRELQM-LQKESSMAEKEQTSNRKRVEELSLELS-EALRKLENSDKEKRQ 427
K+K + + + + L+ L + + Q + V + +L+ E +R+LENS E +
Sbjct: 2336 KEKNEKLFKNYQTLKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEKIRELENSLHEAK- 2394
Query: 428 LQKTVAEQDMKMNDMLDRIKHQHREQGSIKCKLEEDLQEATKLLEDKREQLKKSKEHEKL 487
E M + +++ + I KL+ + E+ K LE +E ++ ++ L
Sbjct: 2395 ------ESAMHKESKIIKMQKELEVTNDIIAKLQAKVHESNKCLEKTKETIQVLQDKVAL 2448
Query: 488 ----MEGELEALRQEFKKKDKTLKENSRKLEEE------------------NENLRAELQ 525
+ E+E L+ + K D +N+++ E+E ENLR Q
Sbjct: 2449 GAKPYKEEIEDLKMKLVKIDLEKMKNAKEFEKEISATKATVEYQKEVIRLLRENLRRSQQ 2508
Query: 526 CCSTQLESSLNKYNTSQQVIQDLNKEIALQKESLMSLQAQ---LDKALQKEKHYLQTTIT 582
T + S S + + +Q + L+++ L+K + K K + I
Sbjct: 2509 AQDTSVISEHTDPQPSNKPLTCGGGSGIVQNTKALILKSEHIRLEKEISKLKQQNEQLI- 2567
Query: 583 KEAYDALSRKSAACQD-----DLTQALEKLNHVTSETKSLQQSLTQTQEKKAQL 631
K+ + LS + + T E VT E +T T KK Q+
Sbjct: 2568 KQKNELLSNNQHLSNEVKTWKERTLKREAHKQVTCENSPKSPKVTGTASKKKQI 2621
Score = 44.7 bits (104), Expect = 4e-04
Identities = 96/434 (22%), Positives = 183/434 (42%), Gaps = 67/434 (15%)
Query: 464 LQEATKLLEDKREQLKKSKEHEKLMEGELEALRQEFKKKDKTLKENSRKLEEENENLRAE 523
L+ K + D ++QL++ + E + L Q ++KD K + K+ ENL
Sbjct: 345 LKRYRKEIMDLKKQLEEVSLETRAQAMEKDQLAQLLEEKDLLQKVQNEKI----ENLTRM 400
Query: 524 LQCCSTQLESSLNKYNTSQQVIQDLNKEIALQKESLMSLQAQLDKALQKEKHYLQTTITK 583
L S+ K ++V L K I K S + Q + + + H L + +
Sbjct: 401 LVTSSSLTLQQELKAKRKRRVTWCLGK-INKMKNSNYADQFNIPTNITTKTHKLSINLLR 459
Query: 584 EAYDALSRKSAACQDDL--------TQALEKLN--HVTSETKSL-----------QQSLT 622
E +++ +S + L A + LN ++ SE SL +Q T
Sbjct: 460 EIDESVCSESDVFSNTLDTLSEIEWNPATKLLNQENIESELNSLRADYDNLVLDYEQLRT 519
Query: 623 QTQEKKAQLEE--EIIAYE--ERMKKLNTELRKLRGFHQESELEVHA--FDKKLE-EMSC 675
+ +E + +L+E ++ +E ER K + E++ + L HA +++ LE E+S
Sbjct: 520 EKEEMELKLKEKNDLDEFEALERKTKKDQEMQLIHEISNLKNLVKHAEVYNQDLENELSS 579
Query: 676 QVLQWQKQHQNDLKMLAAKEEQLREFQEEMAALK-ENL-------LEDDKEPCCLPQWSV 727
+V ++L KE+Q+++ QE + + K EN+ LE ++P + Q
Sbjct: 580 KV-----------ELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQTLF 628
Query: 728 PKDTCRLYRGNDQIM---TNLEQWAKQQKVAN--EKLGNQL---REQVKYIAKLSGEKDR 779
+T L + NLE K +++A +++ N + + Q++ K+ + ++
Sbjct: 629 DAETVALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEK 688
Query: 780 EPTRASSPNTTRPSSPSHSHLHSVMVHLQQE------NKKLKKEIEEKKMKAENTRLCTK 833
E A + T S ++ +L+ E K+L KE+EE + E L ++
Sbjct: 689 ELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEALREEVILLSE 748
Query: 834 ALG-PSRTESTQRE 846
PS E ++E
Sbjct: 749 LKSLPSEVERLRKE 762
Score = 40.8 bits (94), Expect = 0.006
Identities = 93/483 (19%), Positives = 200/483 (41%), Gaps = 56/483 (11%)
Query: 370 KQKADTIQELQRELQMLQKESSMAEKEQTSNRKRVEELSLELSEALRKLENSDKEK--RQ 427
K+ I +L+++L+ E S+ + Q + ++ +L LE + L+K++N E R
Sbjct: 346 KRYRKEIMDLKKQLE----EVSLETRAQAMEKDQLAQL-LEEKDLLQKVQNEKIENLTRM 400
Query: 428 L---------QKTVAEQDMKMNDMLDRIKHQHREQGSIKCKLEEDLQEATKLLEDK--RE 476
L Q+ A++ ++ L +I + + + ++ T L RE
Sbjct: 401 LVTSSSLTLQQELKAKRKRRVTWCLGKINKMKNSNYADQFNIPTNITTKTHKLSINLLRE 460
Query: 477 QLKKSKEHEKLMEGELEALRQEFKKKDKTLKENSRKLEEENENLRAE---LQCCSTQLES 533
+ + L+ L E + T N +E E +LRA+ L QL +
Sbjct: 461 IDESVCSESDVFSNTLDTL-SEIEWNPATKLLNQENIESELNSLRADYDNLVLDYEQLRT 519
Query: 534 SLNKYNTSQQVIQDLNKEIALQKESLMSLQAQLDKALQKEKHYLQTTITKEAYDALSRKS 593
+ + DL++ AL++++ + QL + K+ ++ E Y +
Sbjct: 520 EKEEMELKLKEKNDLDEFEALERKTKKDQEMQLIHEISNLKNLVKHA---EVY------N 570
Query: 594 AACQDDLTQALEKLNHVTSETKSLQQSLTQTQEKKAQLE----EEIIAYEERMKKLNTEL 649
+++L+ +E L + K LQ+ + + + +++ E I ++MK+ +
Sbjct: 571 QDLENELSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQTLFDA 630
Query: 650 RKLRGFHQESELEVHAFDKKLEEMSCQVLQWQKQHQNDLKMLAAKEEQLREFQEEMAALK 709
+ + + + + +L+E ++ KQ +ND+++ ++ E ++ Q ++
Sbjct: 631 ETVALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKEL 690
Query: 710 ENLLEDDKEPCCLPQWSVPKDTCRLYRGNDQIMTNLEQWAK---QQKVANEKL--GNQLR 764
++ + + L VPKD ++ NLE K QK N+++ LR
Sbjct: 691 QSAFNEITKLTSLIDGKVPKD----------LLCNLELEGKITDLQKELNKEVEENEALR 740
Query: 765 EQVKYIAKLSG-----EKDREPTRASSPNTTRPSSPSHSHLHSVMVHLQQENKKLKKEIE 819
E+V +++L E+ R+ + S +S L S +VH + + L +EI
Sbjct: 741 EEVILLSELKSLPSEVERLRKEIQDKSEELHIITS-EKDKLFSEVVHKESRVQGLLEEIG 799
Query: 820 EKK 822
+ K
Sbjct: 800 KTK 802
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 125 bits (313), Expect = 2e-28
Identities = 171/732 (23%), Positives = 315/732 (43%), Gaps = 91/732 (12%)
Query: 132 LIKLQADFASCTATHRYPPSSSEECE-DIKKILKHLQEQKDSQCLHVEEYQNLVKDLRVE 190
L+KL+ + S T T ++ + E + KILK ++++ VE +N + +
Sbjct: 462 LLKLEMENQSLTKTVEELRTTVDSVEGNASKILK-MEKENQRLSKKVEILENEIVQEKQS 520
Query: 191 LEAVSEQKRNIMKDMMKLELDLHGLREETSAHI-----ERKDKDITILQCRLQELQLEFT 245
L+ +++MK+ +LE + LRE + I E + + T+ R Q Q+
Sbjct: 521 LQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLR-QRSQISAE 579
Query: 246 ETQKLTLKKDKFLQEKDEMLQELEKKLTQVQNSLLKKEKELEKQQCMATELEMTVKEAKQ 305
K K++K L E ++E KL++++ + +KELE + E E
Sbjct: 580 ARVKDIEKENKILHES---IKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHH 636
Query: 306 DKSKEAECKALQAEVQKLKNSLE--EAKQQERLAAQQAAQCKEEAALAGCHLEDTQRKLQ 363
E E + LQ ++ LK + E EA +QE LE RKL+
Sbjct: 637 ---LEKENELLQKKITNLKITCEKIEALEQEN-----------------SELERENRKLK 676
Query: 364 KGLLLDKQKADTIQELQRELQMLQKESSMAEKEQTSNRKRVEELSL-ELSEALRKLENSD 422
K L D+ + L +L+ L+KE+S ++E R+ VE L + A +LEN +
Sbjct: 677 KTL-------DSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKE 729
Query: 423 --KEKRQLQK--TVAEQDMKMNDMLD-----------RIKHQHREQGSIKCKLEEDLQEA 467
EK QL+K + + K + L+ R++ +LE +LQ+
Sbjct: 730 LESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQD- 788
Query: 468 TKLLEDKREQLKKSKEHEKLMEGELEALRQEFKKKDKT---LKENSRKLEEENENLRAEL 524
LE + + L+K+ E K+ LE L +E K ++ L+++ ++LE+EN+ LR +
Sbjct: 789 ---LEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQA 845
Query: 525 QCCSTQLESSLNKYNTSQQVIQDLNKEIALQKESLMSLQAQLDKALQKEKHYLQTTITKE 584
+ T LE + K ++ + L+KEI + KES + L K L+KE L T +
Sbjct: 846 EIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRL-----KELEKENKELVKRATID 900
Query: 585 AYDALSRKSAACQDDLTQALEKLNHVTSETKSLQQSLTQTQEKKAQLEEEIIAYEERMKK 644
+ ++DL K + ++ + L L + K +L + + ++R K
Sbjct: 901 I-----KTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKL 955
Query: 645 LNTELRK-LRGFHQESELEVHAFDKKLEEMSCQVLQWQKQHQNDLKMLAAKEEQLREFQE 703
L ++L L+ + E ++ A + +LEE + + +Q + +LK + E L++ Q+
Sbjct: 956 LESKLESTLKKSLEIKEEKIAALEARLEEST----NYNQQLRQELKTVKKNYEALKQRQD 1011
Query: 704 EMAAL--------KENLLEDDKEPCCLPQWSVPKDTCRLYRGNDQIMTNLEQWAKQQKVA 755
E + ++N E + + V + R N + +Q K Q
Sbjct: 1012 EERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAE-KQALKTQLKQ 1070
Query: 756 NEKLGNQLREQVKYIAKLSGEKDREPTRASSPNTTRPSSPSHSHLHSVMVHLQQENKKLK 815
E N L+ Q+ + + + + T + N +S L+S L +N +L
Sbjct: 1071 LETQNNNLQAQILALQRQTVSLQEQNTTLQTQNA--KLQVENSTLNSQSTSLMNQNAQLL 1128
Query: 816 KEIEEKKMKAEN 827
I++ ++ EN
Sbjct: 1129 --IQQSSLENEN 1138
Score = 112 bits (279), Expect = 2e-24
Identities = 209/935 (22%), Positives = 390/935 (41%), Gaps = 173/935 (18%)
Query: 6 ENTGEKLHLAQEQLALAGDKIASLERSLNLYRDKYQSSLSNIELLECQVKMLQGELGGIM 65
+ T + HL+ E LA A KI L + L ++ +E +E ++K LQ E ++
Sbjct: 241 KRTESRQHLSVE-LADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLL 299
Query: 66 GQEPENKGDHSKVRIYTSPCMIQEHQETQKRLSEVWQKVSQQDDLIQELR------NKLA 119
D R+Y + +E R+ ++ +VS+ + + ++ +L
Sbjct: 300 S-------DARSARMYRDE--LDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELK 350
Query: 120 CSNALVLEREKALI-KLQADFASCTATHRYPPSSSEECEDIKKILKHLQEQKDSQCLHVE 178
N ++LE + L +L+ A H +E +K L ++ ++D +E
Sbjct: 351 EDNQVLLETKTMLEDQLEGTRARSDKLHEL----EKENLQLKAKLHDMEMERDMDRKKIE 406
Query: 179 EYQNLVKDLRVELEAVSEQKRNIMKDMMKLELDLHGLREETSAHIERKDKDITILQCRLQ 238
E + + + LE +Q M + + L +L E+ S E + L +
Sbjct: 407 E----LMEENMTLEMAQKQS---MDESLHLGWEL----EQISRTSELSEAPQKSLGHEVN 455
Query: 239 ELQLEFTETQKLTLKKDKFLQEKDEMLQELEKKLTQVQNSLLKKEKELEKQQCMATELEM 298
EL T LK + Q + ++EL + V+ + K K ++ Q ++ ++E+
Sbjct: 456 EL------TSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEI 509
Query: 299 TVKEAKQDKSKEAECKALQAEVQKLKNSLEEA----------------KQQERL-----A 337
E Q+K C+ L ++ K K LE+ ++ E L +
Sbjct: 510 LENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSS 569
Query: 338 AQQAAQCKEEAALAGCH-------------------LEDTQRKLQKGLLLDKQKADTIQE 378
+Q +Q EA + +E +R+++K L K+K + +E
Sbjct: 570 LRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEE 629
Query: 379 LQRELQMLQKESSMAEKEQTSNRKRVEELSLELSEALRKLENS--DKEKRQLQKTV---- 432
L+ EL L+KE+ + +K+ T+ + ++ E EAL + ENS ++E R+L+KT+
Sbjct: 630 LENELHHLEKENELLQKKITNLK-----ITCEKIEALEQ-ENSELERENRKLKKTLDSFK 683
Query: 433 -----AEQDMKMNDMLDRIKHQ-HREQGSIKCKLEE--DLQEATKLLEDKREQLKKSKEH 484
E K N LD + R S+KC + LQ K LE ++EQLKK
Sbjct: 684 NLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKG--- 740
Query: 485 EKLMEGELEALRQEFKKKDKTLKENSRKLEEENENLRAELQCCS---TQLESSLNKYNTS 541
LE L+ FKK ++ L+ + + L+ EN+ L+ L+ + QLES L
Sbjct: 741 -------LELLKASFKKTER-LEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEME 792
Query: 542 QQVIQDLNKEIALQKESLMSLQAQLDKALQKEKHYLQTTITK-EAYDALSRKSAACQD-D 599
Q +Q +E+ + + L L+ + +K+L++E L+ + E + R+ A +D
Sbjct: 793 NQTLQKNLEELKISSKRLEQLEKE-NKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTT 851
Query: 600 LTQALEKLNHVTSETKSLQQSLTQTQEKKAQLEEEIIAYEERMKKLNTELRKLRGFHQES 659
L + K+ ++ E K+L + + +E +L+E ++K N EL K +
Sbjct: 852 LEENNVKIGNLEKENKTLSKEIGIYKESCVRLKE--------LEKENKELVK------RA 897
Query: 660 ELEVHAFDKKLEEMSCQVLQWQKQHQNDLKMLAAKEEQLREFQEEMAALKENLLEDDKEP 719
+++ E++ + L+ Q Q NDL E+L E++ KE LL D++
Sbjct: 898 TIDIKTLVTLREDLVSEKLKTQ-QMNNDL-------EKLTHELEKIGLNKERLLHDEQS- 948
Query: 720 CCLPQWSVPKDTCRLYRGNDQIMTNLEQWAKQQKVA--------NEKLGNQLREQVKYIA 771
D +L + K++K+A + QLR+++K +
Sbjct: 949 --------TDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVK 1000
Query: 772 K----LSGEKDREPTRASSPNTT-------RPSSPSHSHLHSV---MVHLQQENKKLKKE 817
K L +D E SSP + R S + L V ++ +++ N L+ E
Sbjct: 1001 KNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAE 1060
Query: 818 -----IEEKKMKAENTRLCTKALGPSRTESTQREK 847
+ K+++ +N L + L R + +E+
Sbjct: 1061 KQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQ 1095
Score = 100 bits (248), Expect = 8e-21
Identities = 198/918 (21%), Positives = 371/918 (40%), Gaps = 146/918 (15%)
Query: 14 LAQEQLALAGDKIASLERSLNLYRDKYQSSLSNIELLECQVKMLQGELG-----GIMGQE 68
L Q A ++ +E+ + + + + S + +E + + ++ EL G +E
Sbjct: 570 LRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEE 629
Query: 69 PENKGDHSKVRIYTSPCMIQEHQETQKRLSEVWQKVSQQDDLIQELRNKLACSNALVLER 128
EN+ H + +E++ QK+++ + + + L QE LER
Sbjct: 630 LENELHHLE----------KENELLQKKITNLKITCEKIEALEQENSE---------LER 670
Query: 129 EKALIKLQAD-FASCTATHRYPPSSSEECEDIKKILKHLQEQKDSQCLHVEEYQNLVKDL 187
E +K D F + T + + ++ L+ E + + + Q K+L
Sbjct: 671 ENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKEL 730
Query: 188 RVELEAVS---EQKRNIMKDMMKLELDLHGL---REETSAHIERKDKDITILQCRLQELQ 241
E E + E + K +LE+ GL + +E +K I L+ LQ+L+
Sbjct: 731 ESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLE 790
Query: 242 LEFTETQKLTLKKDKFLQEKDEMLQELEKKLTQVQNSLLKKEKELEKQQC---MATELEM 298
+E QK L++ K ++ E L++ K L Q + L K +K+LEK+ E++
Sbjct: 791 MENQTLQK-NLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKD 849
Query: 299 TVKEAKQDK--SKEAECKALQAEVQKLKNSLEEAKQQERLAAQQAAQCKEEAALAGCHLE 356
T E K + E E K L E+ K S K+ E+ + + + A + L
Sbjct: 850 TTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEK----ENKELVKRATIDIKTLV 905
Query: 357 DTQRKLQKGLLLDKQKADTIQELQRELQM--LQKESSMAEKEQTSNRKRVEELSLE---- 410
+ L L +Q + +++L EL+ L KE + +++ T +R ++ E LE
Sbjct: 906 TLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLK 965
Query: 411 ------------LSEALRKLENSDKEKRQLQKTVAE--QDMKMNDMLDRIKHQHREQGSI 456
L L + N +++ RQ KTV + + +K +R+
Sbjct: 966 KSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGE 1025
Query: 457 KCKLEEDLQEATKLLEDKREQLKKSKEHEKLMEGELEALRQEFKK--------------- 501
K E + QE T+ L +++L + + + ++ E +AL+ + K+
Sbjct: 1026 DNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILAL 1085
Query: 502 ---------KDKTLKENSRKLEEENENLRAELQCCSTQLESSLNKYNTSQQVIQDLNKEI 552
++ TL+ + KL+ EN L ++ ST L + + Q +++ N+ +
Sbjct: 1086 QRQTVSLQEQNTTLQTQNAKLQVENSTLNSQ----STSLMNQNAQLLIQQSSLENENESV 1141
Query: 553 ALQKESLMSLQAQLDKALQKEKHYLQTTITKEAYDALSRKSAACQDDLTQALEKLNHVTS 612
++E L SL L K EK L Y++L K L A + L
Sbjct: 1142 IKEREDLKSLYDSLIK--DHEKLELLHERQASEYESLISKHGT----LKSAHKNLE---V 1192
Query: 613 ETKSLQQSLTQTQEKKAQLE----------EEIIAYEERMKKLNTELRKLRGFHQESELE 662
E + L+ Q ++K QLE E+++ + + + E +KL G E++
Sbjct: 1193 EHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCG---ENDRL 1249
Query: 663 VHAFDKKLEEMSCQVLQWQKQHQNDLKMLAAKEEQLREFQEEMAALKENLLEDDKEPCCL 722
H + + L+E +VL Q H+N +L + + + E + LKE + D L
Sbjct: 1250 NHTYSQLLKE--TEVL--QTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKL 1305
Query: 723 PQWSVPKDTCRL---YRGN---------DQIMTNLEQ--WAKQQKVANEKLGNQLREQVK 768
+ C L +GN DQI T + Q +Q + ++ L + EQ +
Sbjct: 1306 ------NNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHV--EQRQ 1357
Query: 769 YIAKLSG-EKDREPTRASSPNTTRPSSPSHSHLHSVMVHLQQENK-KLKKEIEEKKMKAE 826
YI KL+ + +E + + PS + L+ K KK+I ++ K
Sbjct: 1358 YIDKLNELRRQKEKLEEKIMDQYKFYDPSPPRRRGNWITLKMRKLIKSKKDINRERQK-- 1415
Query: 827 NTRLCTKALGPSRTESTQ 844
+ L P+R++S++
Sbjct: 1416 -----SLTLTPTRSDSSE 1428
>gi|156104908 myosin heavy chain 6 [Homo sapiens]
Length = 1939
Score = 125 bits (313), Expect = 2e-28
Identities = 176/807 (21%), Positives = 334/807 (41%), Gaps = 124/807 (15%)
Query: 78 VRIYTSPCMIQEHQETQKRLSEVWQKVSQQDDLIQ--ELRNKLACSNALVLEREKALIKL 135
+++Y + + ET+K ++ + ++ + + ++ E R K + L +EK ++L
Sbjct: 832 MKLYFKIKPLLKSAETEKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQL 891
Query: 136 QADFASCTATHRYPPSSSEECEDIKKILKHLQEQKDSQCLHVEEYQNLVKDLRVELEAVS 195
Q A + E C+ + K L+ + +E+ + + +L + +
Sbjct: 892 QVQ-----AEQDNLNDAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLE 946
Query: 196 EQKRNIMKDMMKLELDLHGLREETSAHIERKDKDITILQCRLQELQLEFTETQKLTLKKD 255
++ + KD+ LEL L + +E A E K K++T L E+ KLT +K
Sbjct: 947 DECSELKKDIDDLELTLAKVEKEKHA-TENKVKNLTEEMAGLDEI------IAKLTKEKK 999
Query: 256 KFLQEKDEMLQELEKKLTQVQNSLLKKEKELEKQQCMATELEMTVKEAKQ--------DK 307
+ + L +L+ + +V NSL K + +LE+Q +LE ++++ K+ +
Sbjct: 1000 ALQEAHQQALDDLQVEEDKV-NSLSKSKVKLEQQ---VDDLEGSLEQEKKVRMDLERAKR 1055
Query: 308 SKEAECKALQAEVQKLKNSL----EEAKQQERLAAQQAAQCKEEAALAGCHLEDTQRKLQ 363
E + K Q + L+N E+ K++E QQ ++ ++E LA +LQ
Sbjct: 1056 KLEGDLKLTQESIMDLENDKLQLEEKLKKKEFDINQQNSKIEDEQVLA--------LQLQ 1107
Query: 364 KGLLLDKQKADTIQELQRELQMLQKESSMAEKEQTSNRKRVEELSLELSEALRKLENSDK 423
K L K+ I+EL+ EL+ + + EK ++ + +EE+S L EA +
Sbjct: 1108 KKL---KENQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEA----GGATS 1160
Query: 424 EKRQLQKTVAEQDMKMNDMLDRIKHQHREQGSIKCKLEED----LQEATKLLEDKREQLK 479
+ ++ K + KM L+ QH + K D L E L+ +++L+
Sbjct: 1161 VQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLE 1220
Query: 480 KSKEHEKLMEGELEALRQEFKKKDKTLKENSRKLEEENENLRAELQCCSTQLESSLNKYN 539
K K KL ++ + ++ K L++ SR LE++ R +L+ + + SLN +
Sbjct: 1221 KEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRVKLE----EAQRSLNDFT 1276
Query: 540 TSQQVIQDLNKEIALQ---KESLMS---------------LQAQLD---KALQKEKHYLQ 578
T + +Q N E+A Q KE+L+S L+ QL+ KA H LQ
Sbjct: 1277 TQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQ 1336
Query: 579 TT-----ITKEAYDALSRKSAACQDDL---------------TQALEKLNHVTSETKSLQ 618
+ + +E Y+ + A Q L T A+++ + K L
Sbjct: 1337 SARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLA 1396
Query: 619 QSLTQTQEKKAQLEEEIIAYEERMKKLNTELRKLRGFHQESELEVHAFDKKLEEMSCQVL 678
Q L +E + + + E+ +L E+ L + S A DKK +
Sbjct: 1397 QRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILA 1456
Query: 679 QWQKQHQNDLKMLAAKEEQLREFQEEMAALKENLLEDDKEPCCLPQWSVPKDTCRLYRGN 738
+W+++++ L + +++ R E+ LK N E+ E
Sbjct: 1457 EWKQKYEESQSELESSQKEARSLSTELFKLK-NAYEESLE-------------------- 1495
Query: 739 DQIMTNLEQWAKQQKVANEKLGN---QLREQVKYIAKLSG-EKDREPTRASSPNTTRPSS 794
+LE + ++ K E++ + QL E K + +L K E + + +
Sbjct: 1496 -----HLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKVRKQLEVEKLELQSALEEAE 1550
Query: 795 PSHSHLHSVMVHLQQENKKLKKEIEEK 821
S H ++ Q E ++K EIE K
Sbjct: 1551 ASLEHEEGKILRAQLEFNQIKAEIERK 1577
Score = 109 bits (273), Expect = 1e-23
Identities = 176/890 (19%), Positives = 371/890 (41%), Gaps = 93/890 (10%)
Query: 2 GNHNENTGEKLHLAQEQLALAGDKIASLERSLNLYRDKYQSSLSNIELLECQVKMLQGEL 61
G+ + ++ L + + L GD + E ++L DK Q ++ E + ++
Sbjct: 1038 GSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLE-EKLKKKEFDINQQNSKI 1096
Query: 62 GG--IMGQEPENKGDHSKVRIYTSPCMIQEHQETQKRLSEVWQKVSQQDDLIQELRNKLA 119
++ + + K ++ RI ++ + + ++ ++ +S++ + I E +
Sbjct: 1097 EDEQVLALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAG 1156
Query: 120 CSNALVLE----REKALIKLQADFASCTATHRYPPSS-----SEECEDIKKILKHLQEQK 170
+ ++ +E RE K++ D T H ++ ++ ++ + + +LQ K
Sbjct: 1157 GATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVK 1216
Query: 171 DSQCLHVEEYQNLVKDLRVELEAVSEQKRNIMKDMMKLELDLHGLREETSAHIERKDKDI 230
E++ + D+ +E + + K N+ K LE + R + +R D
Sbjct: 1217 QKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRVKLE-EAQRSLNDF 1275
Query: 231 TILQCRLQELQLEFTETQKLTLKKDKFLQEKDEMLQELEKKLTQVQNSLLKKEKELEKQQ 290
T + +LQ TE +L + L+EK+ ++ +L + + +++LE++
Sbjct: 1276 TTQRAKLQ------TENGELARQ----LEEKEALISQLTRGKLSYTQQMEDLKRQLEEEG 1325
Query: 291 CMATELEMTVKEAKQD-------KSKEAECKALQAEVQKLKNS----------------- 326
L ++ A+ D +E E KA V NS
Sbjct: 1326 KAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRT 1385
Query: 327 --LEEAKQQERLAAQQAAQCKEEAALAGCHLEDTQRKLQ---KGLLLDKQKADT----IQ 377
LEEAK++ Q A + E LE T+ +LQ + L++D ++++ +
Sbjct: 1386 EELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALD 1445
Query: 378 ELQRELQMLQKESSMAEKEQTSNRKRVEELSLELSEALRKLENSDKEKRQLQKTVAEQDM 437
+ QR + E +E S + ++ + LS L KL+N+ +E + +T ++
Sbjct: 1446 KKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENK 1505
Query: 438 KMNDMLDRIKHQHREQGSIKCKLEEDLQ--EATKL-LEDKREQLKKSKEHE--KLMEGEL 492
+ + + + Q E G +LE+ + E KL L+ E+ + S EHE K++ +L
Sbjct: 1506 NLQEEISDLTEQLGEGGKNVHELEKVRKQLEVEKLELQSALEEAEASLEHEEGKILRAQL 1565
Query: 493 E--ALRQEFKKKDKTLKENSRKLEEENENLRAELQCCSTQLESSLNKYN----TSQQVIQ 546
E ++ E ++K L E ++E+ N + + T L++ N +++
Sbjct: 1566 EFNQIKAEIERK---LAEKDEEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLRVKKKMEG 1622
Query: 547 DLNK-EIALQKESLMSLQAQLDKALQKEKHYLQTTI--TKEAYDALSRKSAACQDDLTQA 603
DLN+ EI L + M+ +A QK+ LQ+ + T+ D R + ++++
Sbjct: 1623 DLNEMEIQLSHANRMAAEA------QKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIV 1676
Query: 604 LEKLNHVTSETKSLQQSLTQTQEKKAQLEEEIIAYEERMKKLNTELRKLRGFHQESELEV 663
+ N + +E + L+ + QT+ + E+E+I ER++ L+++ L ++ E ++
Sbjct: 1677 ERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMESDL 1736
Query: 664 HAFDKKLEEMSCQVLQWQKQHQNDLKMLAAKEEQLREFQEEMAAL---KENLLEDDKEPC 720
++EE + +++ + + A E+L++ Q+ A L K+N+ + K+
Sbjct: 1737 TQLQSEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKD-- 1794
Query: 721 CLPQWSVPKDTCRLYRGNDQIMTNLEQWAKQQKVANEKLGNQLREQVKYIAKLSGEKDRE 780
L + L G Q+ K + E G EQ + + G + E
Sbjct: 1795 -LQHRLDEAEQIALKGGKKQLQ-------KLEARVRELEGELEAEQKRNAESVKGMRKSE 1846
Query: 781 PTRASSPNTTRPSSPSHSHLHSVMVHLQQENKKLKKEIEEKKMKAENTRL 830
T + L ++ LQ + K K++ EE + +A NT L
Sbjct: 1847 RRIKELTYQTEEDKKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQA-NTNL 1895
Score = 87.8 bits (216), Expect = 4e-17
Identities = 108/541 (19%), Positives = 241/541 (44%), Gaps = 60/541 (11%)
Query: 86 MIQEHQETQKRLSEVWQKVSQQDDLIQELRNKLACSNALVLEREK------ALIKLQADF 139
+ Q Q+ ++ + V K S + L+N++ L+++ E+ AL K Q +F
Sbjct: 1395 LAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEI---EDLMVDVERSNAAAAALDKKQRNF 1451
Query: 140 ASCTAT--HRYPPSSSE------ECEDIKKILKHLQEQKDSQCLHVEEYQNLVKDLRVEL 191
A +Y S SE E + L L+ + H+E ++ K+L+ E+
Sbjct: 1452 DKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEI 1511
Query: 192 EAVSEQKRNIMKDMMKLE----------LDLHGLREETSAHIERKDKDITILQCRLQELQ 241
++EQ K++ +LE L+L EE A +E ++ I Q +++
Sbjct: 1512 SDLTEQLGEGGKNVHELEKVRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIK 1571
Query: 242 LEFTETQKLTLKKDKFLQEK---DEMLQELEKKL---TQVQNSLLKKEKELEKQQCMATE 295
E +KL K ++ Q K ++ L+ L T+ +N +L+ +K++E E
Sbjct: 1572 AEIE--RKLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLRVKKKMEGD---LNE 1626
Query: 296 LEMTVKEAKQDKSK-EAECKALQAEVQKLKNSLEEAKQQERLAAQQAAQCKEEAALAGCH 354
+E+ + A + ++ + + K+LQ+ ++ + L++A + + A + L
Sbjct: 1627 MEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAE 1686
Query: 355 LEDTQRKLQKGLLLDKQKADTIQELQRELQMLQKESSMAEKEQTSNRKRVEELSLELSEA 414
LE+ + +++ K + E +Q+L +++ ++ + +L E+ EA
Sbjct: 1687 LEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQSEVEEA 1746
Query: 415 LRKLENSDKEKRQL---QKTVAEQDMKMNDMLDRIKHQHREQGSIKCKLEEDLQEATKL- 470
+++ N++++ ++ +AE+ K D ++ + L+ L EA ++
Sbjct: 1747 VQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIA 1806
Query: 471 LEDKREQLKKSKEHEKLMEGELEALRQE-------FKKKDKTLKENSRKLEEENENL--- 520
L+ ++QL+K + + +EGELEA ++ +K ++ +KE + + EE+ +NL
Sbjct: 1807 LKGGKKQLQKLEARVRELEGELEAEQKRNAESVKGMRKSERRIKELTYQTEEDKKNLLRL 1866
Query: 521 -------RAELQCCSTQLESSLNKYNTSQQVIQDLNKEIALQKESLMSLQAQLDKALQKE 573
+ +++ Q E + + NT+ + + E+ +E ++Q++K K
Sbjct: 1867 QDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAKS 1926
Query: 574 K 574
+
Sbjct: 1927 R 1927
>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
sapiens]
Length = 1937
Score = 125 bits (313), Expect = 2e-28
Identities = 195/872 (22%), Positives = 382/872 (43%), Gaps = 121/872 (13%)
Query: 10 EKLHLAQEQLALAGDKIASLERSLNLYRDKYQSSLSNIELLECQVKMLQGELGGIMGQEP 69
+K+ Q ++ G++I + ER+ +K +S LS EL E ++ E GG +
Sbjct: 1109 KKIKELQARIEELGEEIEA-ERASRAKAEKQRSDLSR-ELEEISERL--EEAGGATSAQV 1164
Query: 70 E----NKGDHSKVRIYTSPCMIQEHQET---QKRLSEVWQKVSQQDDLIQELRNKLACSN 122
E + + K+R +Q +K+ ++ ++ +Q D +Q ++ KL
Sbjct: 1165 ELNKKREAEFQKLRRDLEEATLQHEAMVAALRKKHADSMAELGEQIDNLQRVKQKL---- 1220
Query: 123 ALVLEREKALIKLQADFASCTATHRYPPSSSEECEDIKKILKHLQEQKDSQCLHVEEYQN 182
E+EK+ +K++ D S A + S+ +++K+ + L++Q EE Q
Sbjct: 1221 ----EKEKSELKMETDDLSSNAE-----AISKAKGNLEKMCRSLEDQVSELKTKEEEQQR 1271
Query: 183 LVKDL-----RVELEA-------------VSEQKRNIMKDMMKLELDLHGLREETSAH-- 222
L+ DL R++ EA VS+ R+ ++E H L EET A
Sbjct: 1272 LINDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQASTQQIEELKHQLEEETKAKNA 1331
Query: 223 ----IERKDKDITILQCRLQELQLEFTETQKLTLKKDKFLQEKDEMLQELEKKLTQVQNS 278
++ D +L+ + +E Q E Q+ K + E+ + T+ +
Sbjct: 1332 LAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANS----------EVAQWRTKYETD 1381
Query: 279 LLKKEKELEKQQCMATELEMTVKEAKQD-KSKEAECKALQAEVQKLKNSLEEAKQQ-ERL 336
+++ +ELE+ + +L ++EA++ ++ A+C +L+ Q+L+N +E+ ER
Sbjct: 1382 AIQRTEELEEAK---KKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERS 1438
Query: 337 AAQQAAQCKEEAALAGCHLEDTQRKLQKGLLLDKQKADTIQELQRELQMLQKESSMAEKE 396
A AA L+ QR K L KQK +E Q EL+ QKES E
Sbjct: 1439 NAACAA------------LDKKQRNFDKVLSEWKQK---YEETQAELEASQKESRSLSTE 1483
Query: 397 QTSNRKRVEELSLELSEALRKLENSDKEKRQLQKTVAEQDMKMNDMLDRIKHQHREQGSI 456
+ EE +L R+ +N +E L + +AE ++++ L++IK Q ++
Sbjct: 1484 LFKVKNVYEESLDQLETLRRENKNLQQEISDLTEQIAEGGKQIHE-LEKIKKQVEQE--- 1539
Query: 457 KCKLEEDLQEATKLLEDKREQLKKSKEHEKLMEGELEALRQEFKKKDKTLKENSRKLEEE 516
KC+++ L+EA LE E K++ +LE L Q + D+ + E ++++
Sbjct: 1540 KCEIQAALEEAEASLEH---------EEGKILRIQLE-LNQVKSEVDRKIAEKDEEIDQL 1589
Query: 517 NENLRAELQCCSTQLESSLNKYNTSQQVIQDLNKEIALQKESLMSLQAQLDKALQKEKHY 576
N ++ + L++ + N + +V + + ++ E + L A + ++Y
Sbjct: 1590 KRNHTRVVETMQSTLDAEIRSRNDALRVKKKMEGDL---NEMEIQLNHANRLAAESLRNY 1646
Query: 577 LQTT-ITKEAYDALSRKSAACQDDLTQAL----EKLNHVTSETKSLQQSLTQTQEKKAQL 631
T I KE L + Q+DL + L + N + +E + L +L QT+ +
Sbjct: 1647 RNTQGILKETQLHLD-DALRGQEDLKEQLAIVERRANLLQAEIEELWATLEQTERSRKIA 1705
Query: 632 EEEIIAYEERMKKLNTELRKLRGFHQESELEVHAFDKKLEEMSCQVLQWQKQHQNDLKML 691
E+E++ ER++ L+T+ L ++ E +V ++EE+ + +++ + +
Sbjct: 1706 EQELLDASERVQLLHTQNTSLINTKKKLENDVSQLQSEVEEVIQESRNAEEKAKKAITDA 1765
Query: 692 AAKEEQLREFQEEMAAL---KENLLEDDKEPCCLPQWSVPKDTCRLYRGNDQI------M 742
A E+L++ Q+ A L K+NL + K+ L + L G QI +
Sbjct: 1766 AMMAEELKKEQDTSAHLERMKKNLEQTVKD---LQHRLDEAEQLALKGGKKQIQKLEARV 1822
Query: 743 TNLEQWAKQQKVANEKLGNQLREQVKYIAKLS--GEKDREPTRASSPNTTRPSSPSHSHL 800
LE + ++ N + LR+ + + +L+ E+DR+ + + S+
Sbjct: 1823 RELEGEVENEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNVLRLQDLVDKLQAKVKSYK 1882
Query: 801 HSVMVHLQQEN------KKLKKEIEEKKMKAE 826
+Q N +KL+ E+EE + +A+
Sbjct: 1883 RQAEEAEEQSNANLSKFRKLQHELEEAEERAD 1914
Score = 119 bits (299), Expect = 9e-27
Identities = 170/826 (20%), Positives = 347/826 (42%), Gaps = 120/826 (14%)
Query: 25 KIASLERSLNLYRDKYQSSLSNIELLECQVKMLQGELGGIMGQ------EPENKGDHSKV 78
K A E+ + ++++Q + + E + K L+ ++ ++ + + +++ D
Sbjct: 844 KSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSLAD 903
Query: 79 RIYTSPCMIQEHQETQKRLSEVWQKVSQQDDLIQELRNKLACSNALVLEREKALIKLQAD 138
+I+ + + ++ EV ++ +++++ EL K E +K + L+
Sbjct: 904 AEERCEQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDLELT 963
Query: 139 FASCT----ATHRYPPSSSEECEDIKKILKHLQEQKDSQCLHVEEYQNLVKDLRVELEAV 194
A AT + +EE + + + L ++K + E +Q + DL+ E
Sbjct: 964 LAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKAL---QETHQQTLDDLQAE---- 1016
Query: 195 SEQKRNIM-KDMMKLELDLHGLREETSAHIERKDKDITILQCRLQELQLEFTETQKLTLK 253
E K NI+ K KLE + ++ +E++ K L+ ++L+ + Q+ T+
Sbjct: 1017 -EDKVNILTKAKTKLEQQV----DDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMD 1071
Query: 254 KDKFLQEKDEMLQELEKKLTQVQNSLLKKEKELEKQQCMATELEMTVKEAKQDKSKEAEC 313
+ Q+ DE +LEKK ++ N + K +E +Q + +L+ +KE
Sbjct: 1072 MENDKQQLDE---KLEKKEFEISNLISK----IEDEQAVEIQLQKKIKE----------- 1113
Query: 314 KALQAEVQKLKNSLEEAKQQERLAAQQAAQCKEEAALAGCHLEDTQRKLQKGLLLDKQKA 373
LQA +++L +E + A +Q + E LE+ + L+K++
Sbjct: 1114 --LQARIEELGEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQVELNKKRE 1171
Query: 374 DTIQELQRELQ--MLQKESSMAEKEQTSNRKRVEELSLELSEALRKLENSDKEKRQLQKT 431
Q+L+R+L+ LQ E+ +A + RK+ + EL E +++N + K++L+K
Sbjct: 1172 AEFQKLRRDLEEATLQHEAMVA-----ALRKKHADSMAELGE---QIDNLQRVKQKLEKE 1223
Query: 432 VAEQDMKMNDMLDRIKHQHREQGSIKCKLEEDLQEATKLLEDKREQLKKSKEHEKLMEGE 491
+E M+ +D+ + + +G+ L++ + LED+ +LK +E ++ + +
Sbjct: 1224 KSELKMETDDLSSNAEAISKAKGN--------LEKMCRSLEDQVSELKTKEEEQQRLIND 1275
Query: 492 LEALR-----------QEFKKKDKTLKENSRKLEEENENLRAELQCCSTQLESSLNKYNT 540
L A R ++ +KD + + SR + + + EL+ QLE N
Sbjct: 1276 LTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQASTQQIE-ELK---HQLEEETKAKNA 1331
Query: 541 SQQVIQDLNKEIALQKESLMSLQ---AQLDKALQKEKHYLQTTITKEAYDALSRKSAACQ 597
+Q + L +E Q A+L +AL K + TK DA+ R
Sbjct: 1332 LAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQR------ 1385
Query: 598 DDLTQALEKLNHVTSETKSLQQSLTQTQEKKAQLEEEIIAYEERMKKLNTELRKLRGFHQ 657
T+ LE+ K L Q L + +E + + + E+ ++L E+ L +
Sbjct: 1386 ---TEELEEAK------KKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVE 1436
Query: 658 ESELEVHAFDKKLEEMSCQVLQWQKQHQNDLKMLAAKEEQLREFQEEMAALKENLLEDDK 717
S A DKK + +W+++++ L A +++ R E+ +K N+ E+
Sbjct: 1437 RSNAACAALDKKQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTELFKVK-NVYEESL 1495
Query: 718 EPCCLPQWSVPKDTCRLYRGNDQIMT-NLEQWAKQQKVANEKLGNQLREQVKYIAKLSG- 775
DQ+ T E QQ++++ L Q+ E K I +L
Sbjct: 1496 ---------------------DQLETLRRENKNLQQEISD--LTEQIAEGGKQIHELEKI 1532
Query: 776 EKDREPTRASSPNTTRPSSPSHSHLHSVMVHLQQENKKLKKEIEEK 821
+K E + + S H ++ +Q E ++K E++ K
Sbjct: 1533 KKQVEQEKCEIQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRK 1578
Score = 89.4 bits (220), Expect = 1e-17
Identities = 142/704 (20%), Positives = 304/704 (43%), Gaps = 87/704 (12%)
Query: 28 SLERSLNLYRDKYQSSLSNIELLECQVKMLQGELGGIMGQEPENKGDHSKV--------- 78
SLE ++ + K + I L Q LQ E G Q E S++
Sbjct: 1254 SLEDQVSELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQASTQ 1313
Query: 79 RIYTSPCMIQEHQETQKRLSEVWQKVSQQDDLIQELRNKLACSNALVLEREKALIKLQAD 138
+I ++E + + L+ Q DL++E + A E ++AL K ++
Sbjct: 1314 QIEELKHQLEEETKAKNALAHALQSSRHDCDLLREQYEEEQEGKA---ELQRALSKANSE 1370
Query: 139 FASCTATHRYPP-SSSEECEDIKKIL-KHLQEQKD------SQCLHVEE----YQNLVKD 186
A + +EE E+ KK L + LQE ++ ++C +E+ QN V+D
Sbjct: 1371 VAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVED 1430
Query: 187 LRVELE-------AVSEQKRNIMKDMMKLELDLHGLREETSAHIERKDKDITILQCRLQE 239
L +++E A+ +++RN K + + + EET A +E K+ L L +
Sbjct: 1431 LMLDVERSNAACAALDKKQRNFDKVLSEWKQKY----EETQAELEASQKESRSLSTELFK 1486
Query: 240 LQLEFTET--QKLTLKKDK--FLQEKDEMLQELEKKLTQVQNSLLKKEKELEKQQCMATE 295
++ + E+ Q TL+++ QE ++ +++ + Q+ + L K +K++E+++C E
Sbjct: 1487 VKNVYEESLDQLETLRRENKNLQQEISDLTEQIAEGGKQI-HELEKIKKQVEQEKC---E 1542
Query: 296 LEMTVKEAKQD-KSKEAECKALQAEVQKLKNSLEE--AKQQERLAAQQAAQCKEEAALAG 352
++ ++EA+ + +E + +Q E+ ++K+ ++ A++ E + + + +
Sbjct: 1543 IQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQS 1602
Query: 353 CHLEDTQRKLQKGLLLDKQKADTIQELQRELQMLQKESSMAEKEQTSNRKRVEELSLELS 412
L+ R L + K+ + E++ +L + ++ + + + + ++E L L
Sbjct: 1603 T-LDAEIRSRNDALRVKKKMEGDLNEMEIQLNHANRLAAESLRNYRNTQGILKETQLHLD 1661
Query: 413 EALRKLENSDK-----------------------EKRQLQKTVAEQDMKMNDMLDRIKHQ 449
+ALR E+ + E+ + + +AEQ++ D +R++
Sbjct: 1662 DALRGQEDLKEQLAIVERRANLLQAEIEELWATLEQTERSRKIAEQELL--DASERVQLL 1719
Query: 450 HREQGSI---KCKLEEDLQEATKLLEDKREQLKKSKEHEKLMEGELEALRQEFKKKDKTL 506
H + S+ K KLE D+ + +E+ ++ + ++E K + + +E KK+ T
Sbjct: 1720 HTQNTSLINTKKKLENDVSQLQSEVEEVIQESRNAEEKAKKAITDAAMMAEELKKEQDT- 1778
Query: 507 KENSRKLEEENENLRAELQCCSTQLESS----LNKYNTSQQVIQDLNKEIALQKESLMSL 562
S LE +NL ++ +L+ + L Q ++ +E+ + E+
Sbjct: 1779 ---SAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVENEQKR 1835
Query: 563 QAQLDKALQKEKHYLQTTITKEAYDALSRKSAACQDDLTQALE-KLNHVTSETKSLQQSL 621
A+ K L+K + ++ + D RK+ DL L+ K+ + + ++
Sbjct: 1836 NAEAVKGLRKHERRVKELTYQTEED---RKNVLRLQDLVDKLQAKVKSYKRQAEEAEEQS 1892
Query: 622 TQTQEKKAQLEEEIIAYEERMKKLNTELRKLRGFHQESELEVHA 665
K +L+ E+ EER +++ KLR +E ++ A
Sbjct: 1893 NANLSKFRKLQHELEEAEERADIAESQVNKLRVKSREVHTKISA 1936
Score = 68.9 bits (167), Expect = 2e-11
Identities = 93/426 (21%), Positives = 180/426 (42%), Gaps = 22/426 (5%)
Query: 433 AEQDMKMNDMLDRIKHQHREQGSIKCKLEEDLQEATKLLEDKRE-QLKKSKEHEKLMEGE 491
AE + +M M + + E + K +E ++ LL++K + QL+ E + L + E
Sbjct: 846 AETEKEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSLADAE 905
Query: 492 LEALRQEFKKK---DKTLKENSRKLEEENENLRAELQCCSTQLESSLNKYNTSQQVIQDL 548
E Q K K + +KE + + EEE E + AEL +LE ++ I DL
Sbjct: 906 -ERCEQLIKNKIQLEAKIKEVTERAEEEEE-INAELTAKKRKLEDECSELKKD---IDDL 960
Query: 549 NKEIALQKESLMSLQAQLDKALQKEKHYLQTTITKEAYD--ALSRKSAACQDDLTQALEK 606
+A ++ + + ++ K L +E L TI K + + AL DDL +K
Sbjct: 961 ELTLAKVEKEKHATENKV-KNLTEEMAGLDETIAKLSKEKKALQETHQQTLDDLQAEEDK 1019
Query: 607 LNHVTSETKSLQQSLTQTQEKKAQLEEEIIAYEERMKKLNTELRKLRGFHQESELEVHAF 666
+N +T L+Q + + Q ++ + E +KL +L+ + + E +
Sbjct: 1020 VNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDMENDKQQL 1079
Query: 667 DKKLEEMSCQVLQWQKQHQNDLKMLAAKEEQLREFQEEMAALKENLLEDDKEPCCLPQWS 726
D+KLE+ ++ + +++ + +++++E Q + L E + +
Sbjct: 1080 DEKLEKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERASRA-----K 1134
Query: 727 VPKDTCRLYRGNDQIMTNLEQWAKQQKVANEKLGNQLREQVKYIAKLSGEKDREPTRASS 786
K L R ++I LE+ E N+ RE + E+ A
Sbjct: 1135 AEKQRSDLSRELEEISERLEEAGGATSAQVEL--NKKREAEFQKLRRDLEEATLQHEAMV 1192
Query: 787 PNTTRPSSPSHSHLHSVMVHLQQENKKLKKEIEEKKMKAENTRLCTKALGPSRTESTQRE 846
+ + S + L + +LQ+ +KL+KE E KM+ ++ +A+ ++ E
Sbjct: 1193 AALRKKHADSMAELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAK---GNLE 1249
Query: 847 KVCGTL 852
K+C +L
Sbjct: 1250 KMCRSL 1255
>gi|38044112 restin isoform b [Homo sapiens]
Length = 1392
Score = 124 bits (311), Expect = 4e-28
Identities = 193/874 (22%), Positives = 386/874 (44%), Gaps = 114/874 (13%)
Query: 16 QEQLALAGDKIASLERSLNLYR-----DKYQSSLSNIELLECQVKML----QGELGGIMG 66
++ LAL ++A L R L + D S L I L+ ++++ Q E+ +
Sbjct: 470 EKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKE 529
Query: 67 QEPENKGDHSKV--RIYTSPCMIQEHQETQKRLSEVWQKVSQQDDLIQELRNKLACSNAL 124
+ H K +YT+ + + E+ K E K + D+I ++KL +
Sbjct: 530 HFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANK--ENSDVIALWKSKLETA--- 584
Query: 125 VLEREKALIKLQADFASCTATHRYPPSSSEECEDIKKI-------LKHLQEQKDSQ-CLH 176
+ ++A+ +L+ F+ T +E I+K+ +++LQ Q+DS+ H
Sbjct: 585 IASHQQAMEELKVSFSKGLGTET--AEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAH 642
Query: 177 VEEYQNL-------VKDLRVELEAV-SEQKRNIMKDMMKLELDLHGLREETSAHIERKDK 228
+E + L +K+ LEA+ S+ + + ++++E L+ L+E A I+ K+
Sbjct: 643 AKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQE---AEIKVKEL 699
Query: 229 DITILQCRLQELQLE-FTETQKLTLKKDKFLQEKDEMLQELEKKLTQVQNSLLKKEKELE 287
++ +C Q ++ FT K T +EK L L K ++ ++ + K ++LE
Sbjct: 700 EVLQAKCNEQTKVIDNFTSQLKAT-------EEKLLDLDALRKASSEGKSEMKKLRQQLE 752
Query: 288 KQQCMATELEMTVK-EAKQDKSKEAECKALQAEVQKLKNSLEEAKQQERLAAQQAAQCKE 346
+ LE+ E+ + S E + + ++ L+ +L E Q + ++ KE
Sbjct: 753 AAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKE 812
Query: 347 EAALAGCHLEDTQRKLQKGLLLDKQKADTIQELQRELQMLQKESSMAEKEQTSNRKRVEE 406
+ A A QR +Q+ + QK + L +L+ L++ + E + +R E+
Sbjct: 813 KFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQ 872
Query: 407 LSLELSEALRKLENSDKEKRQLQKTVAEQDMKMNDMLDRIKHQHREQGSIKCKLEEDLQE 466
L K K +L+ +AE MKM+ + S K+ ++L+
Sbjct: 873 LI--------------KAKEKLENDIAE-IMKMSG----------DNSSQLTKMNDELRL 907
Query: 467 ATKLLEDKREQLKKSKEHEKLMEGELEALRQEFKKKDKTLKENSRKLEEENENLRAELQC 526
+ +E+ + +L K+ E+ ++ +E + K +++ +E ++K EEE + L +L
Sbjct: 908 KERDVEELQLKLTKANENASFLQKSIEDMT---VKAEQSQQEAAKKHEEEKKELERKLSD 964
Query: 527 CSTQLESSLN-------KYNTSQQVIQDLNKEIA--LQKESLMSLQAQLDKALQKEKHYL 577
++E+S N +Y + + ++EI LQK +L+ + +L A ++ L
Sbjct: 965 LEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQK-TLLDTEDKLKGAREENSGLL 1023
Query: 578 Q--TTITKEAYDALSRKSAACQDDLTQALEKLNHVTSETKSLQQSLTQTQEKKAQLEEEI 635
Q + K+A A K+A +D Q +E++ +ET + SL T++ A+L+ E+
Sbjct: 1024 QELEELRKQADKA---KAAQTAEDAMQIMEQMTKEKTETLA---SLEDTKQTNAKLQNEL 1077
Query: 636 IAYEERMKKLNTELRKLRGFHQESELEVHAFDKKLEEMSCQVLQWQKQHQNDLKMLAAKE 695
+E K EL K + ++ F K++E + + A K
Sbjct: 1078 DTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLK--------------QAAAQKS 1123
Query: 696 EQLREFQEEMAALKENLLEDDKEPCCLPQWSVPKDTCRLYRGNDQIMTNLEQWAKQQKVA 755
+QL QEE L E L E + + N+Q++ ++ +K K A
Sbjct: 1124 QQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVL-----NNQLLEMKKRESKFIKDA 1178
Query: 756 NEKLGNQLREQVKYIAKLSGEKDREPTRASSPNTT-RPSSPSHSHLHSVMVHLQQENKKL 814
+E+ + L++ + + L EKD E + + T R + S LHSV+ L+ + KL
Sbjct: 1179 DEEKAS-LQKSISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKL 1237
Query: 815 KKEIEEKKMK-AENTRLCTKALGPSRTESTQREK 847
+ +++ +++ EN R + + G + T++ + E+
Sbjct: 1238 ELKVKNLELQLKENKRQLSSSSGNTDTQADEDER 1271
Score = 101 bits (252), Expect = 3e-21
Identities = 146/663 (22%), Positives = 279/663 (42%), Gaps = 99/663 (14%)
Query: 214 GLREETSAHIERKDKDITILQCRLQELQ-----------LEFTETQKLTLKKDKFLQE-- 260
GL ETS+ RK T LQ L+E Q LE E K T + QE
Sbjct: 334 GLLTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELA 393
Query: 261 -----KDEMLQELEKKLTQVQNSLLKKEKELEKQQCMATELEMTVKEAKQDKSKEAECKA 315
D+ + ELE K+ Q++ + ++E ++E+ + + +++K K + +
Sbjct: 394 LARDGHDQHVLELEAKMDQLRTMVEAADRE---------KVEL-LNQLEEEKRKVEDLQF 443
Query: 316 LQAEVQKLKNSLEEAKQQERLAAQQAAQCKEEAALAGCHLEDTQRKLQKGLLLDKQKADT 375
E K LE A E+ + + +++ AL + + +R+L+ +K D
Sbjct: 444 RVEEESITKGDLEVATVSEK---SRIMELEKDLALRVQEVAELRRRLES----NKPAGD- 495
Query: 376 IQELQRELQMLQKESSMAEKEQTSNRKRVEELSLELSEALRKLENSDKEKRQLQKTVAEQ 435
+ L +LQ+ SS+ EK + + E++ L E E + +++ + T E+
Sbjct: 496 ---VDMSLSLLQEISSLQEKLEVTRTDHQREIT-SLKEHFGAREETHQKEIKALYTATEK 551
Query: 436 DMKMNDML-DRIKHQHREQGSI----KCKLEEDLQEATKLLEDKREQLKKSKEHEKL--- 487
K N+ L +++H ++E + K KLE + + +E+ + K E
Sbjct: 552 LSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFA 611
Query: 488 -MEGELEALRQEFKKKDKTLKENSRKLE-----EENENLRAELQCCSTQLESSLNKYNTS 541
++ ++E +R +++ + + L +N + E +E E LRA+L + E+SL +
Sbjct: 612 ELKTQIEKMRLDYQHEIENL-QNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSK 670
Query: 542 QQVIQD---------LNK--EIALQKESLMSLQAQLDKALQKEKHYL-QTTITKEAY--- 586
+D LNK E ++ + L LQA+ ++ + ++ Q T+E
Sbjct: 671 LDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDL 730
Query: 587 DALSRKSAACQDDLTQALEKLNHVTSETKSLQQSLTQTQEKKAQLEEEIIAYEERMKKLN 646
DAL + S+ + ++ + ++L + K L+ K + + E+ E ++ L
Sbjct: 731 DALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQ 790
Query: 647 TELRKLRGFHQESELEVHAFDKKLEEMSCQVLQWQKQHQNDLKMLAAKEEQLREFQEEMA 706
L ++ + E E+ +K E S + + Q+ Q + L KEEQ ++
Sbjct: 791 ENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLE 850
Query: 707 ALKENLLEDDKEPCCLPQWSVPKDTCRLYRGNDQIMTNLEQWAKQQKVANEKLGNQLREQ 766
L+ENL + + + +R D+ EQ K A EKL N + E
Sbjct: 851 KLRENLADMEAK----------------FREKDE---REEQLIK----AKEKLENDIAE- 886
Query: 767 VKYIAKLSGEKDREPTRASSPNTTRPSSPSHSHLHSVMVHLQQENKKLKKEIEEKKMKAE 826
I K+SG+ + T+ + + R L + + L+K IE+ +KAE
Sbjct: 887 ---IMKMSGDNSSQLTKMN--DELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAE 941
Query: 827 NTR 829
++
Sbjct: 942 QSQ 944
Score = 83.2 bits (204), Expect = 1e-15
Identities = 126/591 (21%), Positives = 239/591 (40%), Gaps = 76/591 (12%)
Query: 16 QEQLALAGDKIASLERSLNLYRDKYQSSLSNIELLECQVKMLQGELGGIMGQEPENKGDH 75
++QL A +I LE N K S ++ E ++ LQ EN +
Sbjct: 748 RQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQ-----------ENLSEV 796
Query: 76 SKVRIYTSPCMIQEHQETQKRLSEVWQKVSQQDDLIQELRNKLACSNALVLEREKALIKL 135
S+V+ + +E Q +++ +E ++ +QE NKL L KL
Sbjct: 797 SQVK----ETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKL 852
Query: 136 QADFASCTATHRYPPSSSEEC--------EDIKKILKHLQEQKDSQCLHVEEYQNL---- 183
+ + A A R E+ DI +I+K + SQ + + L
Sbjct: 853 RENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMK-MSGDNSSQLTKMNDELRLKERD 911
Query: 184 VKDLRVELEAVSEQKRNIMKDMMKLELDLHGLR-------EETSAHIERK----DKDITI 232
V++L+++L +E + K + + + + EE +ERK +K +
Sbjct: 912 VEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMET 971
Query: 233 LQCRLQELQLEFTE-TQKLTLKKDKFLQEKDEMLQELEKKL--TQVQNSLLKKEKELEKQ 289
+ QEL+ + T + K ++ LQ + L + E KL + +NS L +E E ++
Sbjct: 972 SHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRK 1031
Query: 290 QCMATELEMTVKEAKQ-----DKSKEAECKALQAEVQ---KLKNSLEEAKQQERLAAQQA 341
Q + T ++A Q K K +L+ Q KL+N L+ K+ ++
Sbjct: 1032 QADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEEL 1091
Query: 342 AQCKEEAALAGCHLEDTQRKLQKGLLLDKQKADTIQELQRELQMLQKESSMAEKEQTSNR 401
+ KE + +E+ +++++ QK+ + LQ E L +E + E TS++
Sbjct: 1092 NKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQ 1151
Query: 402 KRVEELS------LELSEALRK-LENSDKEKRQLQKTVAEQDMKMNDMLDRIKHQHREQG 454
K EE S LE+ + K ++++D+EK LQK+++ + + +
Sbjct: 1152 KLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAEL-------- 1203
Query: 455 SIKCKLEEDLQEATKLLEDKREQLKKSKEHEKLMEGELEALRQEFKKKDKTLKENSRKLE 514
E L+ +L + K + +E + L + K + LKEN R+L
Sbjct: 1204 -------EKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLS 1256
Query: 515 EENENLRAELQCCSTQLESSLNKYNT----SQQVIQDLNKEIALQKESLMS 561
+ N + ES ++ N+ Q+ QDL ++ + E+ ++
Sbjct: 1257 SSSGNTDTQADEDERAQESQIDFLNSVIVDLQRKNQDLKMKVEMMSEAALN 1307
>gi|4506751 restin isoform a [Homo sapiens]
Length = 1427
Score = 124 bits (311), Expect = 4e-28
Identities = 193/874 (22%), Positives = 386/874 (44%), Gaps = 114/874 (13%)
Query: 16 QEQLALAGDKIASLERSLNLYR-----DKYQSSLSNIELLECQVKML----QGELGGIMG 66
++ LAL ++A L R L + D S L I L+ ++++ Q E+ +
Sbjct: 505 EKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKE 564
Query: 67 QEPENKGDHSKV--RIYTSPCMIQEHQETQKRLSEVWQKVSQQDDLIQELRNKLACSNAL 124
+ H K +YT+ + + E+ K E K + D+I ++KL +
Sbjct: 565 HFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANK--ENSDVIALWKSKLETA--- 619
Query: 125 VLEREKALIKLQADFASCTATHRYPPSSSEECEDIKKI-------LKHLQEQKDSQ-CLH 176
+ ++A+ +L+ F+ T +E I+K+ +++LQ Q+DS+ H
Sbjct: 620 IASHQQAMEELKVSFSKGLGTET--AEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAH 677
Query: 177 VEEYQNL-------VKDLRVELEAV-SEQKRNIMKDMMKLELDLHGLREETSAHIERKDK 228
+E + L +K+ LEA+ S+ + + ++++E L+ L+E A I+ K+
Sbjct: 678 AKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQE---AEIKVKEL 734
Query: 229 DITILQCRLQELQLE-FTETQKLTLKKDKFLQEKDEMLQELEKKLTQVQNSLLKKEKELE 287
++ +C Q ++ FT K T +EK L L K ++ ++ + K ++LE
Sbjct: 735 EVLQAKCNEQTKVIDNFTSQLKAT-------EEKLLDLDALRKASSEGKSEMKKLRQQLE 787
Query: 288 KQQCMATELEMTVK-EAKQDKSKEAECKALQAEVQKLKNSLEEAKQQERLAAQQAAQCKE 346
+ LE+ E+ + S E + + ++ L+ +L E Q + ++ KE
Sbjct: 788 AAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKE 847
Query: 347 EAALAGCHLEDTQRKLQKGLLLDKQKADTIQELQRELQMLQKESSMAEKEQTSNRKRVEE 406
+ A A QR +Q+ + QK + L +L+ L++ + E + +R E+
Sbjct: 848 KFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQ 907
Query: 407 LSLELSEALRKLENSDKEKRQLQKTVAEQDMKMNDMLDRIKHQHREQGSIKCKLEEDLQE 466
L K K +L+ +AE MKM+ + S K+ ++L+
Sbjct: 908 LI--------------KAKEKLENDIAE-IMKMSG----------DNSSQLTKMNDELRL 942
Query: 467 ATKLLEDKREQLKKSKEHEKLMEGELEALRQEFKKKDKTLKENSRKLEEENENLRAELQC 526
+ +E+ + +L K+ E+ ++ +E + K +++ +E ++K EEE + L +L
Sbjct: 943 KERDVEELQLKLTKANENASFLQKSIEDMT---VKAEQSQQEAAKKHEEEKKELERKLSD 999
Query: 527 CSTQLESSLN-------KYNTSQQVIQDLNKEIA--LQKESLMSLQAQLDKALQKEKHYL 577
++E+S N +Y + + ++EI LQK +L+ + +L A ++ L
Sbjct: 1000 LEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQK-TLLDTEDKLKGAREENSGLL 1058
Query: 578 Q--TTITKEAYDALSRKSAACQDDLTQALEKLNHVTSETKSLQQSLTQTQEKKAQLEEEI 635
Q + K+A A K+A +D Q +E++ +ET + SL T++ A+L+ E+
Sbjct: 1059 QELEELRKQADKA---KAAQTAEDAMQIMEQMTKEKTETLA---SLEDTKQTNAKLQNEL 1112
Query: 636 IAYEERMKKLNTELRKLRGFHQESELEVHAFDKKLEEMSCQVLQWQKQHQNDLKMLAAKE 695
+E K EL K + ++ F K++E + + A K
Sbjct: 1113 DTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLK--------------QAAAQKS 1158
Query: 696 EQLREFQEEMAALKENLLEDDKEPCCLPQWSVPKDTCRLYRGNDQIMTNLEQWAKQQKVA 755
+QL QEE L E L E + + N+Q++ ++ +K K A
Sbjct: 1159 QQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVL-----NNQLLEMKKRESKFIKDA 1213
Query: 756 NEKLGNQLREQVKYIAKLSGEKDREPTRASSPNTT-RPSSPSHSHLHSVMVHLQQENKKL 814
+E+ + L++ + + L EKD E + + T R + S LHSV+ L+ + KL
Sbjct: 1214 DEEKAS-LQKSISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKL 1272
Query: 815 KKEIEEKKMK-AENTRLCTKALGPSRTESTQREK 847
+ +++ +++ EN R + + G + T++ + E+
Sbjct: 1273 ELKVKNLELQLKENKRQLSSSSGNTDTQADEDER 1306
Score = 108 bits (270), Expect = 2e-23
Identities = 152/681 (22%), Positives = 286/681 (41%), Gaps = 100/681 (14%)
Query: 214 GLREETSAHIERKDKDITILQCRLQELQ-----------LEFTETQKLTLKKDKFLQE-- 260
GL ETS+ RK T LQ L+E Q LE E K T + QE
Sbjct: 334 GLLTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELA 393
Query: 261 -----KDEMLQELEKKLTQVQNSLLKKEKE-------LEKQQCMATELEMTVKEAKQDKS 308
D+ + ELE K+ Q++ + ++E LE+++ +L+ V+E K
Sbjct: 394 LARDGHDQHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKG 453
Query: 309 K-EAECKALQAEVQKLKNSLEEAKQQERLAAQQAAQCKEEAALAGCHLEDTQRKLQKGLL 367
E + K A +++L+ SL E+ A + + E+ +A + +L+K L
Sbjct: 454 DLETQTKLEHARIKELEQSL----LFEKTKADKLQRELEDTRVATVSEKSRIMELEKDLA 509
Query: 368 LDKQKADTIQ----------ELQRELQMLQKESSMAEKEQTSNRKRVEELSLELSEALRK 417
L Q+ ++ ++ L +LQ+ SS+ EK + + E++ L E
Sbjct: 510 LRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREIT-SLKEHFGA 568
Query: 418 LENSDKEKRQLQKTVAEQDMKMNDML-DRIKHQHREQGSI----KCKLEEDLQEATKLLE 472
E + +++ + T E+ K N+ L +++H ++E + K KLE + + +E
Sbjct: 569 REETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAME 628
Query: 473 DKREQLKKSKEHEKL----MEGELEALRQEFKKKDKTLKENSRKLE-----EENENLRAE 523
+ + K E ++ ++E +R +++ + + L +N + E +E E LRA+
Sbjct: 629 ELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENL-QNQQDSERAAHAKEMEALRAK 687
Query: 524 LQCCSTQLESSLNKYNTSQQVIQD---------LNK--EIALQKESLMSLQAQLDKALQK 572
L + E+SL + +D LNK E ++ + L LQA+ ++ +
Sbjct: 688 LMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKV 747
Query: 573 EKHYL-QTTITKEAY---DALSRKSAACQDDLTQALEKLNHVTSETKSLQQSLTQTQEKK 628
++ Q T+E DAL + S+ + ++ + ++L + K L+ K
Sbjct: 748 IDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKA 807
Query: 629 AQLEEEIIAYEERMKKLNTELRKLRGFHQESELEVHAFDKKLEEMSCQVLQWQKQHQNDL 688
+ + E+ E ++ L L ++ + E E+ +K E S + + Q+ Q +
Sbjct: 808 SSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETV 867
Query: 689 KMLAAKEEQLREFQEEMAALKENLLEDDKEPCCLPQWSVPKDTCRLYRGNDQIMTNLEQW 748
L KEEQ ++ L+ENL + + + +R D+ EQ
Sbjct: 868 NKLHQKEEQFNMLSSDLEKLRENLADMEAK----------------FREKDE---REEQL 908
Query: 749 AKQQKVANEKLGNQLREQVKYIAKLSGEKDREPTRASSPNTTRPSSPSHSHLHSVMVHLQ 808
K A EKL N + E I K+SG+ + T+ + + R L +
Sbjct: 909 IK----AKEKLENDIAE----IMKMSGDNSSQLTKMN--DELRLKERDVEELQLKLTKAN 958
Query: 809 QENKKLKKEIEEKKMKAENTR 829
+ L+K IE+ +KAE ++
Sbjct: 959 ENASFLQKSIEDMTVKAEQSQ 979
Score = 83.2 bits (204), Expect = 1e-15
Identities = 126/591 (21%), Positives = 239/591 (40%), Gaps = 76/591 (12%)
Query: 16 QEQLALAGDKIASLERSLNLYRDKYQSSLSNIELLECQVKMLQGELGGIMGQEPENKGDH 75
++QL A +I LE N K S ++ E ++ LQ EN +
Sbjct: 783 RQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQ-----------ENLSEV 831
Query: 76 SKVRIYTSPCMIQEHQETQKRLSEVWQKVSQQDDLIQELRNKLACSNALVLEREKALIKL 135
S+V+ + +E Q +++ +E ++ +QE NKL L KL
Sbjct: 832 SQVK----ETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKL 887
Query: 136 QADFASCTATHRYPPSSSEEC--------EDIKKILKHLQEQKDSQCLHVEEYQNL---- 183
+ + A A R E+ DI +I+K + SQ + + L
Sbjct: 888 RENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMK-MSGDNSSQLTKMNDELRLKERD 946
Query: 184 VKDLRVELEAVSEQKRNIMKDMMKLELDLHGLR-------EETSAHIERK----DKDITI 232
V++L+++L +E + K + + + + EE +ERK +K +
Sbjct: 947 VEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMET 1006
Query: 233 LQCRLQELQLEFTE-TQKLTLKKDKFLQEKDEMLQELEKKL--TQVQNSLLKKEKELEKQ 289
+ QEL+ + T + K ++ LQ + L + E KL + +NS L +E E ++
Sbjct: 1007 SHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRK 1066
Query: 290 QCMATELEMTVKEAKQ-----DKSKEAECKALQAEVQ---KLKNSLEEAKQQERLAAQQA 341
Q + T ++A Q K K +L+ Q KL+N L+ K+ ++
Sbjct: 1067 QADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEEL 1126
Query: 342 AQCKEEAALAGCHLEDTQRKLQKGLLLDKQKADTIQELQRELQMLQKESSMAEKEQTSNR 401
+ KE + +E+ +++++ QK+ + LQ E L +E + E TS++
Sbjct: 1127 NKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQ 1186
Query: 402 KRVEELS------LELSEALRK-LENSDKEKRQLQKTVAEQDMKMNDMLDRIKHQHREQG 454
K EE S LE+ + K ++++D+EK LQK+++ + + +
Sbjct: 1187 KLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAEL-------- 1238
Query: 455 SIKCKLEEDLQEATKLLEDKREQLKKSKEHEKLMEGELEALRQEFKKKDKTLKENSRKLE 514
E L+ +L + K + +E + L + K + LKEN R+L
Sbjct: 1239 -------EKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLS 1291
Query: 515 EENENLRAELQCCSTQLESSLNKYNT----SQQVIQDLNKEIALQKESLMS 561
+ N + ES ++ N+ Q+ QDL ++ + E+ ++
Sbjct: 1292 SSSGNTDTQADEDERAQESQIDFLNSVIVDLQRKNQDLKMKVEMMSEAALN 1342
>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 899
Score = 123 bits (308), Expect = 9e-28
Identities = 140/738 (18%), Positives = 332/738 (44%), Gaps = 83/738 (11%)
Query: 5 NENTGEKLHLAQEQLALAGDKIASLERSLNLYRDKYQSSLSNIELLECQVKMLQGELGGI 64
NE +K QE+L LA + + ++ LN+ K + + L + Q LQ E+
Sbjct: 220 NEELKKKNAELQEKLPLAESEKSEIQ--LNVKELKRKLERAKFLLPQVQTNTLQEEM--- 274
Query: 65 MGQEPENKGDHSKVRIYTSPCMIQEHQETQKRLSEVWQKVSQQDDLIQELRNKLACSNAL 124
QE E + K+R QE +++ +Q+ ++E K+
Sbjct: 275 WRQEEELREQEKKIRKQEEKMWRQE------------ERLREQEGKMREQEEKMWRQEKR 322
Query: 125 VLEREKALIKLQADFASCTATHRYPPSSSEECEDIKKILKHLQEQKDSQCLHVEEYQNLV 184
+ E+EK L + + + E+ E + + + ++EQ++ E
Sbjct: 323 LREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQE 382
Query: 185 KDLRVELEAVSEQKRNIMKDMMKLELDLHGLREETSAHIE----RKDKDITILQCRLQEL 240
K +R + + + +Q+ + + +L +RE+ + R++K + + + ++
Sbjct: 383 KQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQ 442
Query: 241 QLEFTETQKLTLKKDKFLQEKDEMLQELEKKLTQVQNSLLKKEKELEKQQCMATELEMTV 300
+ + E +++ ++ K +E++ M ++ EK Q +N ++EKE ++Q+ E
Sbjct: 443 EEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLP----EQKE 498
Query: 301 KEAKQDKSKEAECKALQAEVQKLKNSLE----EAK--QQERLAAQQAAQCKEEAALAGCH 354
K +Q+K +E E K + E +K+++ E E K +QE++ Q+ ++E +
Sbjct: 499 KLWEQEKMQEQEEKIWEQE-EKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQE 557
Query: 355 LE--DTQRKLQKGLLLDKQKA-DTIQELQRELQMLQKESSMAEKEQT--SNRKRVEELSL 409
+ D + +++K ++K D ++++ E +M ++E M E+E+ ++++E
Sbjct: 558 QKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEE 617
Query: 410 ELSEALRKLENSDKEKRQLQKTVAEQDMKMNDMLDRIKHQHR-EQGSIKCKLEEDLQEAT 468
++ E K+ +++ ++ ++ + EQ+ KM + +++ Q R + K E +QE
Sbjct: 618 KMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQE 677
Query: 469 KLLEDKREQLKKSKEHEKLMEGELEALRQEFKKKDKTLKENSRKLEEENENLRAELQCCS 528
K+ E + + ++ K +K E E + QE +++++++E +K+ EE E +R + +
Sbjct: 678 KMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEE--- 734
Query: 529 TQLESSLNKYNTSQQVIQDLNKEIALQKESLMSLQAQLDKALQKEKHYLQTTITKEAYDA 588
K ++ +Q+ +E+ Q+E + Q+EK + Q + ++
Sbjct: 735 --------KMQEQEEKMQEQEEEMWEQEEKMWE---------QEEKMWEQQRLPEQKEKL 777
Query: 589 LSRKSAACQDDLTQALEKLNHVTSETKSLQQSLTQTQEKKAQLEEEIIAYEERM----KK 644
+ Q+ + + EK+ + + ++ + +EK EE++ EE+M +K
Sbjct: 778 WEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEK 837
Query: 645 LNTELRKLRGFHQESELEVHAFDKKLEEMSCQVLQWQKQHQNDLKMLAAKEEQLREFQEE 704
+ + K+ G ++ E ++ ++K+ E +EE++R +E+
Sbjct: 838 MWGQEEKMWGQEEKMEEKMQGQEEKMRE---------------------QEEKMRGQEEK 876
Query: 705 MAALKENLLEDDKEPCCL 722
M +E + +++ C+
Sbjct: 877 MREQEEKMRGQEEKIYCV 894
Score = 110 bits (275), Expect = 6e-24
Identities = 130/613 (21%), Positives = 293/613 (47%), Gaps = 74/613 (12%)
Query: 239 ELQLEFTETQKLTLKKDKFLQE----KDEMLQELEKKLTQVQNSLLKKEKELEKQQCMA- 293
ELQ + K D++++E +D + EL + T L KK EL+++ +A
Sbjct: 180 ELQRALSAVSTRHKKADRYIEELTKERDALSLELYRN-TITNEELKKKNAELQEKLPLAE 238
Query: 294 ---TELEMTVKEAKQDKSK------EAECKALQAEVQKLKNSLEEAKQQERLAAQQAAQC 344
+E+++ VKE K+ + + + LQ E+ + + L E Q++++ Q+
Sbjct: 239 SEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELRE--QEKKIRKQEEKMW 296
Query: 345 KEEAALA---GCHLEDTQRKLQKGLLLDKQKADTIQELQRELQMLQKESSMAEKEQTSNR 401
++E L G E ++ ++ L +Q+ + ++E ++EL+ QKE E++
Sbjct: 297 RQEERLREQEGKMREQEEKMWRQEKRLREQEKE-LREQEKELRE-QKELREQEEQMQEQE 354
Query: 402 KRVEELSLELSEALRKLENSDKEKRQLQKTVAEQDMKMNDMLDRIKHQH---REQGSIKC 458
+++ E ++ E K+ ++ + +K + EQ+ KM D +R+ Q RE+
Sbjct: 355 EKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMR 414
Query: 459 KLEEDLQEATKLLEDKR--EQLKKSKEHEKLMEGELEALRQEFKK---KDKTLKENSRKL 513
+ E+ ++ K+ E+K+ EQ KK+++ E+ M+ E E +R+ KK +++T++E K+
Sbjct: 415 EQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEE-ERIREREKKMREEEETMREQEEKM 473
Query: 514 EEENENL--RAELQCCSTQLESSLNKYNTSQQVIQDLNKEIALQKESLMSLQAQLDKALQ 571
+++ EN+ + E + +L K Q+ +Q+ ++I Q+E + + Q
Sbjct: 474 QKQEENMWEQEEKEWQQQRLPEQKEKL-WEQEKMQEQEEKIWEQEEKIRDQEEMWG---Q 529
Query: 572 KEKHYLQTTITKEAYDALSRKSAACQDDLTQALEKLNHVTSETKSLQQSL---TQTQEKK 628
++K + Q + ++ +D + + EK+ + ++ + TQ QEKK
Sbjct: 530 EKKMWRQEKMREQ------------EDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKK 577
Query: 629 AQLEEEIIAYEERMKKLNTELRKLRGFHQESELEVHAFDKKLEEMSCQVLQWQKQHQNDL 688
+EE + EERM++ ++R+ +E E ++ ++K++E Q +K + +
Sbjct: 578 TWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQE------QEEKMWEQEE 631
Query: 689 KMLAAKEEQLREFQEEMAALKENLLEDDKEPCCLPQWSVPKDTCRLYRGNDQIMTNLEQW 748
KM +EE++ E +E+M +E + E Q +P+ +L+ ++++ +
Sbjct: 632 KM-QEQEEKMWEQEEKMWEQEEKMWE---------QQRLPEQKEKLWE-HEKMQEQEKMQ 680
Query: 749 AKQQKV-ANEKLGNQLREQVKYIAKLSGEKDREPTRASSPNTTRPSSPSHSHLHSVMVHL 807
+++K+ EK+ + +EQ K + ++++ S + + +
Sbjct: 681 EQEEKIWEQEKMEKKTQEQ----EKKTWDQEKMREEESMREREKKMREEEEMMREQEEKM 736
Query: 808 QQENKKLKKEIEE 820
Q++ +K++++ EE
Sbjct: 737 QEQEEKMQEQEEE 749
Score = 110 bits (275), Expect = 6e-24
Identities = 135/665 (20%), Positives = 313/665 (47%), Gaps = 83/665 (12%)
Query: 157 EDIKKILKHLQEQKDSQCLHVEEYQNLVKDLRVELEAVSEQKRNIMKDMMKLELDLHGLR 216
E++KK LQE+ E Q VK+L+ +LE + ++ + L+
Sbjct: 221 EELKKKNAELQEKLPLAESEKSEIQLNVKELKRKLERAK---------FLLPQVQTNTLQ 271
Query: 217 EETSAHIERKDKDITILQCRLQELQLEFTETQKLTLKKDKFLQEKDEMLQELEKKLTQVQ 276
EE + R+++++ + ++++ + + ++ +++ ++E++E + EK+L + +
Sbjct: 272 EE----MWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQE 327
Query: 277 NSLLKKEKEL-EKQQCMATELEMTVKEAK----QDKSKEAE-------------CKALQA 318
L ++EKEL E+++ E +M +E K ++K +E E K ++
Sbjct: 328 KELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMRE 387
Query: 319 EVQKLKNSLEEA-KQQERLAAQQAAQCKEEAALAGCHLEDTQRKLQKGLLLDKQKADTIQ 377
+ QK+++ E +Q ERL ++ ++E ++K+Q+ + + + +Q
Sbjct: 388 QEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQ 447
Query: 378 E----LQRELQMLQKESSMAEKEQTSNRKRVEELSLELSEALRKLENSDKEKRQLQKTVA 433
E +RE +M ++E +M E+E+ ++ E E ++ KEK Q+ +
Sbjct: 448 EEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQ 507
Query: 434 EQDMKMNDMLDRIKHQH---------------REQGSIKCKLEEDLQEATKLLEDKREQL 478
EQ+ K+ + ++I+ Q REQ + EE +++ + + D+ E++
Sbjct: 508 EQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERM 567
Query: 479 -KKSKEHEKLMEGELEALRQEFKKKDKTLKENSRKLEEENENLRAELQCCSTQLESSLNK 537
KK++E EK + E +R+E + ++E +K+ EE E +R + +++ K
Sbjct: 568 EKKTQEQEKKTWDQEEKMREE-----ERMREREKKMREEEEMMREQ----EEKMQEQEEK 618
Query: 538 YNTSQQVIQDLNKEIALQKESLMSLQAQLDKALQKEKHYLQTTITKEAYDALSRKSAACQ 597
++ + + +++ Q+E + + ++ + Q+EK + Q + ++ + Q
Sbjct: 619 MQEQEEKMWEQEEKMQEQEEKMWEQEEKMWE--QEEKMWEQQRLPEQKEKLWEHEKMQEQ 676
Query: 598 DDLTQALEKLNHVTSETKSLQQSLTQTQEKKAQLEEEIIAYEERMKKLNTELRKLRGFHQ 657
+ + + EK+ E + +++ TQ QEKK ++E + EE M++ ++R+ +
Sbjct: 677 EKMQEQEEKI----WEQEKMEKK-TQEQEKKT-WDQEKMREEESMREREKKMREEEEMMR 730
Query: 658 ESELEVHAFDKKLEEMSCQVLQWQKQHQNDLKMLAAKEEQLREFQEEMAALKENLLEDDK 717
E E ++ ++K++E ++ W+++ + + +EE++ E Q+ + KE L E +K
Sbjct: 731 EQEEKMQEQEEKMQEQEEEM--WEQEEK-----MWEQEEKMWE-QQRLPEQKEKLWEHEK 782
Query: 718 ---EPCCLPQWSVPKDTCRLYRGNDQIMTNLEQWAKQQKVANEKLGNQLREQVKYIAKLS 774
+ Q +D RG ++ M E+ + Q+ EK+ Q + K+
Sbjct: 783 MQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQE---EKMWGQEEKMWGQEEKMW 839
Query: 775 GEKDR 779
G++++
Sbjct: 840 GQEEK 844
Score = 63.9 bits (154), Expect = 6e-10
Identities = 96/437 (21%), Positives = 182/437 (41%), Gaps = 98/437 (22%)
Query: 472 EDKREQLKKSKEHEKLMEGELEALRQEFKKKDKTLK-----------------ENSRKLE 514
ED ++ + KE +K EALR+E + +D T++ + +RK E
Sbjct: 70 EDTQQNRAQLKEEKKASHQHQEALRREIEAQDHTIRILTCQKTELETALYYSQDAARKFE 129
Query: 515 EENENLRAELQCCSTQLESSLNKYNTSQQVIQDLNKEIALQKESLMSLQAQLDKAL---- 570
+ N + +Q S +I +K++A + +L +AL
Sbjct: 130 DGNLGTPSSFNLALSQAFRGSPLGCVSTSLIPGESKDLAGRLHHSWHFAGELQRALSAVS 189
Query: 571 ---QKEKHYLQTTITKEAYDALS--------------RKSAACQD--------------- 598
+K Y++ +TKE DALS +K+A Q+
Sbjct: 190 TRHKKADRYIE-ELTKER-DALSLELYRNTITNEELKKKNAELQEKLPLAESEKSEIQLN 247
Query: 599 --DLTQALEKLNHVTS--ETKSLQQSLTQTQEKKAQLEEEIIAYEERMKKLNTELRKLRG 654
+L + LE+ + +T +LQ+ + + +E+ + E++I EE+M + LR+ G
Sbjct: 248 VKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEG 307
Query: 655 FHQESELEVHAFDKKLEEMSCQVLQWQKQHQNDLKMLAAKEEQLREFQEEMAALKENLLE 714
+E E ++ +K+L E + L+ Q++ + K L +EEQ++E +E+M +E + E
Sbjct: 308 KMREQEEKMWRQEKRLREQE-KELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMRE 366
Query: 715 DDKEPCCLPQ--WSVPKDTCRLYRGNDQIMTNLEQ--WAKQQKVANEKLGNQLREQVKYI 770
+++ + W K R +Q M + E+ W + +++ ++ ++REQ K
Sbjct: 367 QEEKMWRQEERLWEQEKQ----MREQEQKMRDQEERMWEQDERLREKE--ERMREQEKMW 420
Query: 771 AKLSGEKDREPTRASSPNTTRPSSPSHSHLHSVMVHLQQENKKLKKEIEEKKMKAENTRL 830
++ EK RE + QE +K ++ EEK + E R
Sbjct: 421 EQV--EKMREEKK------------------------MQEQEKKTRDQEEKMQEEERIRE 454
Query: 831 CTKALGPSRTESTQREK 847
K + E T RE+
Sbjct: 455 REKKM--REEEETMREQ 469
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 123 bits (308), Expect = 9e-28
Identities = 176/747 (23%), Positives = 321/747 (42%), Gaps = 114/747 (15%)
Query: 132 LIKLQADFASCTATHRYPPSSSEECE-DIKKILKHLQEQKDSQCLHVEEYQNLVKDLRVE 190
L+KL+ + S T T ++ + E + KILK ++++ VE +N + +
Sbjct: 462 LLKLEMENQSLTKTVEELRTTVDSVEGNASKILK-MEKENQRLSKKVEILENEIVQEKQS 520
Query: 191 LEAVSEQKRNIMKDMMKLELDLHGLREETSAHI-----ERKDKDITILQCRLQELQLEFT 245
L+ +++MK+ +LE + LRE + I E + + T+ R Q Q+
Sbjct: 521 LQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLR-QRSQISAE 579
Query: 246 ETQKLTLKKDKFLQEKDEMLQELEKKLTQVQNSLLKKEKELEKQQCMATELEMTVKEAKQ 305
K K++K L E ++E KL++++ + +KELE + E E
Sbjct: 580 ARVKDIEKENKILHES---IKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHH 636
Query: 306 DKSKEAECKALQAEVQKLKNSLE--EAKQQERLAAQQAAQCKEEAALAGCHLEDTQRKLQ 363
E E + LQ ++ LK + E EA +QE LE RKL+
Sbjct: 637 ---LEKENELLQKKITNLKITCEKIEALEQEN-----------------SELERENRKLK 676
Query: 364 KGLLLDKQKADTIQELQRELQMLQKESSMAEKEQTSNRKRVEELSL-ELSEALRKLENSD 422
K L D+ + L +L+ L+KE+S ++E R+ VE L + A +LEN +
Sbjct: 677 KTL-------DSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKE 729
Query: 423 --KEKRQLQK--TVAEQDMKMNDMLD-----------RIKHQHREQGSIKCKLEEDLQEA 467
EK QL+K + + K + L+ R++ +LE +LQ+
Sbjct: 730 LESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQD- 788
Query: 468 TKLLEDKREQLKKSKEHEKLMEGELEALRQEFKKKDKT---LKENSRKLEEENENLRAEL 524
LE + + L+K+ E K+ LE L +E K ++ L+++ ++LE+EN+ LR +
Sbjct: 789 ---LEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQA 845
Query: 525 QCCSTQLESSLNKYNTSQQVIQDLNKEIALQKESLMSLQ--AQLDKALQKEKHYLQTTIT 582
+ T LE + K ++ + L+KEI + KES + L+ + +K L K T+
Sbjct: 846 EIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLV 905
Query: 583 KEAYDALSRKSAACQ-----DDLTQALEKL----NHVTSETKSLQQSLTQTQEKKAQ--L 631
D +S K Q + LT LEK+ + + +S S + E K + L
Sbjct: 906 TLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTL 965
Query: 632 EEEIIAYEERMKKLNTELRKLRGFHQESELEVHAFDKKLEEMSCQVLQWQKQHQNDLKML 691
++ + EE++ L L + ++Q+ E+ K E + KQ Q++ +M+
Sbjct: 966 KKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEAL--------KQRQDEERMV 1017
Query: 692 AAK----------EEQLREFQEEMAALKENLLEDDKEPCCLPQWSVPKDTCRLYRGNDQI 741
+ E + +E E+ +K+ L+E V ++ L +
Sbjct: 1018 QSSPPISGEDNKWERESQETTRELLKVKDRLIE------------VERNNATLQAEKQAL 1065
Query: 742 MTNLEQWAKQ------QKVANEKLGNQLREQVKYIAKLSGEKDREPTRASSPNTTRPSSP 795
T L+Q Q Q +A ++ L+EQ + + + E + +S +T+ +
Sbjct: 1066 KTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMN-- 1123
Query: 796 SHSHLHSVMVHLQQENKKLKKEIEEKK 822
++ L L+ EN+ + KE E+ K
Sbjct: 1124 QNAQLLIQQSSLENENESVIKEREDLK 1150
Score = 114 bits (285), Expect = 4e-25
Identities = 200/920 (21%), Positives = 386/920 (41%), Gaps = 142/920 (15%)
Query: 6 ENTGEKLHLAQEQLALAGDKIASLERSLNLYRDKYQSSLSNIELLECQVKMLQGELGGIM 65
+ T + HL+ E LA A KI L + L ++ +E +E ++K LQ E ++
Sbjct: 241 KRTESRQHLSVE-LADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLL 299
Query: 66 GQEPENKGDHSKVRIYTSPCMIQEHQETQKRLSEVWQKVSQQDDLIQELR------NKLA 119
D R+Y + +E R+ ++ +VS+ + + ++ +L
Sbjct: 300 S-------DARSARMYRDE--LDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELK 350
Query: 120 CSNALVLEREKALI-KLQADFASCTATHRYPPSSSEECEDIKKILKHLQEQKDSQCLHVE 178
N ++LE + L +L+ A H +E +K L ++ ++D +E
Sbjct: 351 EDNQVLLETKTMLEDQLEGTRARSDKLHEL----EKENLQLKAKLHDMEMERDMDRKKIE 406
Query: 179 EYQNLVKDLRVELEAVSEQKRNIMKDMMKLELDLHGLREETSAHIERKDKDITILQCRLQ 238
E + + + LE +Q M + + L +L E+ S E + L +
Sbjct: 407 E----LMEENMTLEMAQKQS---MDESLHLGWEL----EQISRTSELSEAPQKSLGHEVN 455
Query: 239 ELQLEFTETQKLTLKKDKFLQEKDEMLQELEKKLTQVQNSLLKKEKELEKQQCMATELEM 298
EL T LK + Q + ++EL + V+ + K K ++ Q ++ ++E+
Sbjct: 456 EL------TSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEI 509
Query: 299 TVKEAKQDKSKEAECKALQAEVQKLKNSLEEA----------------KQQERL-----A 337
E Q+K C+ L ++ K K LE+ ++ E L +
Sbjct: 510 LENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSS 569
Query: 338 AQQAAQCKEEAALAGCH-------------------LEDTQRKLQKGLLLDKQKADTIQE 378
+Q +Q EA + +E +R+++K L K+K + +E
Sbjct: 570 LRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEE 629
Query: 379 LQRELQMLQKESSMAEKEQTSNRKRVEELSLELSEALRKLENS--DKEKRQLQKTV---- 432
L+ EL L+KE+ + +K+ T+ + ++ E EAL + ENS ++E R+L+KT+
Sbjct: 630 LENELHHLEKENELLQKKITNLK-----ITCEKIEALEQ-ENSELERENRKLKKTLDSFK 683
Query: 433 -----AEQDMKMNDMLDRIKHQ-HREQGSIKCKLEE--DLQEATKLLEDKREQLKKSKEH 484
E K N LD + R S+KC + LQ K LE ++EQLKK
Sbjct: 684 NLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKG--- 740
Query: 485 EKLMEGELEALRQEFKKKDKTLKENSRKLEEENENLRAELQCCS---TQLESSLNKYNTS 541
LE L+ FKK ++ L+ + + L+ EN+ L+ L+ + QLES L
Sbjct: 741 -------LELLKASFKKTER-LEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEME 792
Query: 542 QQVIQDLNKEIALQKESLMSLQAQLDKALQKEKHYLQTTITK-EAYDALSRKSAACQD-D 599
Q +Q +E+ + + L L+ + +K+L++E L+ + E + R+ A +D
Sbjct: 793 NQTLQKNLEELKISSKRLEQLEKE-NKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTT 851
Query: 600 LTQALEKLNHVTSETKSLQQSLTQTQEKKAQLEEEIIAYEERMKKLNTELRKLRGFHQE- 658
L + K+ ++ E K+L + + +E +L+E +E +K+ +++ L ++
Sbjct: 852 LEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDL 911
Query: 659 --SELEVHAFDKKLEEMSCQVLQWQKQHQNDLKMLAAKEEQLREFQEEMAALKENLLEDD 716
+L+ + LE+++ ++L+ + +E+L ++ + LLE
Sbjct: 912 VSEKLKTQQMNNDLEKLT-----------HELEKIGLNKERLLHDEQSTDDSRYKLLESK 960
Query: 717 KEPCCLPQWSVPKDTCRLYRGNDQIMTNLEQWAKQQKVANEKLGNQLREQ------VKYI 770
E + ++ + TN Q +Q+ +K L+++ V+
Sbjct: 961 LESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSS 1020
Query: 771 AKLSGEKDREPTRASSPNTTRPSSPSHSHLHSV---MVHLQQENKKLKKEIEEKKMKAEN 827
+SGE ++ S TTR L V LQ E + LK ++ K+++ +N
Sbjct: 1021 PPISGEDNK--WERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQL--KQLETQN 1076
Query: 828 TRLCTKALGPSRTESTQREK 847
L + L R + +E+
Sbjct: 1077 NNLQAQILALQRQTVSLQEQ 1096
Score = 75.5 bits (184), Expect = 2e-13
Identities = 143/609 (23%), Positives = 254/609 (41%), Gaps = 95/609 (15%)
Query: 10 EKLHLAQEQLALAGDKIASLERSLN-LYRDKYQSSLSNIEL---LECQVKMLQGELGGIM 65
E+L ++ ++L + SLE+ + L +DK Q N L E + L+ I
Sbjct: 801 EELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIG 860
Query: 66 GQEPENKGDHSKVRIYTSPC-----MIQEHQETQKRLS-EVWQKVSQQDDLIQELRNKLA 119
E ENK ++ IY C + +E++E KR + ++ V+ ++DL+ E
Sbjct: 861 NLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQ 920
Query: 120 CSNALV----------LEREKALIKLQADFASCTATHRYPPSSSEECEDIKKILKHLQEQ 169
+N L L +E+ L Q+ T RY S+ +KK L+ +E+
Sbjct: 921 MNNDLEKLTHELEKIGLNKERLLHDEQS-----TDDSRYKLLESKLESTLKKSLEIKEEK 975
Query: 170 KDSQCLHVEEYQNLVKDLRVELEAVSE-----QKRNIMKDMMKLELDLHG--------LR 216
+ +EE N + LR EL+ V + ++R + M++ + G +
Sbjct: 976 IAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQ 1035
Query: 217 EETSAHIERKDKDITI------LQCRLQEL--QLEFTETQKLTL--------KKDKFLQE 260
E T ++ KD+ I + LQ Q L QL+ ETQ L ++ LQE
Sbjct: 1036 ETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQE 1095
Query: 261 KDEMLQELEKKLTQVQNSLLKKEKELEKQQCMATELEMTVKEAKQDKSKEAECKALQAEV 320
++ LQ KL QV+NS L + M ++ ++++ + E+ K + ++
Sbjct: 1096 QNTTLQTQNAKL-QVENSTLNSQST----SLMNQNAQLLIQQSSLENENESVIKERE-DL 1149
Query: 321 QKLKNSLEEAKQQERLAAQQAAQCKEEAALAGCHLEDTQRKLQKGLLLDKQKADTIQELQ 380
+ L +SL K E+L Q E +L H T + K L ++ + +
Sbjct: 1150 KSLYDSL--IKDHEKLELLHERQASEYESLISKH--GTLKSAHKNLEVEHRDLE-----D 1200
Query: 381 RELQMLQKESSMAEKEQTSNRKRVEELSLELSEALRKLENSDKEKRQLQKTVAEQDMKMN 440
R Q+L+++ + + E+ L++ + LEN + E TVA + K+
Sbjct: 1201 RYNQLLKQKGQLEDLEKM----------LKVEQEKMLLENKNHE------TVAAEYKKLC 1244
Query: 441 DMLDRIKHQHREQGSIKCKLEEDLQEATKLLED-KREQLKKSKEHEKLMEG--ELEALRQ 497
DR+ H + + L+ D + LL + K EQ + E KL E +L+
Sbjct: 1245 GENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITST 1304
Query: 498 EFKKKDKTLKENSRKLEEENENLRAELQCCSTQLESSLNK-------YNTSQQVIQDLNK 550
+ + + L + LEEEN +L ++Q Q + L + ++ Q+ D
Sbjct: 1305 KLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLN 1364
Query: 551 EIALQKESL 559
E+ QKE L
Sbjct: 1365 ELRRQKEKL 1373
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 122 bits (307), Expect = 1e-27
Identities = 183/895 (20%), Positives = 357/895 (39%), Gaps = 150/895 (16%)
Query: 16 QEQLALAGDKIASLERSLNLYRDKYQSSLSNIELLECQVKMLQGELGGIMGQEPENKGDH 75
+++L + ++I LE+ R+ + L +E + ++ +G++ +
Sbjct: 1500 EQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDL----------- 1548
Query: 76 SKVRIYTSPCMIQEHQETQKRLSEVWQKVSQQDDLIQELRNKLACSNALVLEREKALIKL 135
K ++ T C+ E +E K+ Q LI+EL + AL L
Sbjct: 1549 -KKQLVTLECLALELEENH-------HKMECQQKLIKELEGQRETQRV-------ALTHL 1593
Query: 136 QADFASCTATHRYPPSSSEECEDIKKILKHLQEQKDSQCLHVEEYQNLVKDLRVELEAVS 195
D + + S + E +L +++D + VK R ++E +
Sbjct: 1594 TLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQE----------VKSQREQIEELQ 1643
Query: 196 EQKRNIMKDMMKLELDLHGLREETSAHIERKDKDITILQCRLQELQLEFTETQKLTLKKD 255
QK ++ +D+ + + +L +E +++ + IL+ L++++L E + +
Sbjct: 1644 RQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQR 1703
Query: 256 KFLQEKDEMLQELEK----KLTQVQNSLLKKEKELEKQQCMATELEMTVKEAKQDKSKEA 311
+ +QE+ E + K L ++ L KEKE+E QQ EL+ + +Q
Sbjct: 1704 QLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQ------ 1757
Query: 312 ECKALQAEVQKLKNSLEEAKQQERLAAQQAAQCKEEAALAGCHLEDTQRKLQKGLLLDKQ 371
+ + L +V + L + +Q+ + QQ + +E+ L L+ + Q+ L Q
Sbjct: 1758 QLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALA---Q 1814
Query: 372 KADTIQELQRELQMLQKESSMAEKEQTSNRKRVEELSLELSEALRKLENSDKEKRQLQKT 431
+ ++ LQ+E Q Q + +++ + + +E+ + L E +L++ ++ R+L++
Sbjct: 1815 RDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEE 1874
Query: 432 VAEQDMK---MNDMLDRIKHQHREQGSIKCKLEED------------------------- 463
+A + + + ++L ++ + REQ L++
Sbjct: 1875 LAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAV 1934
Query: 464 LQEATKLLEDKREQLKKSKEHEKLMEGELEALRQEFKKKDKTLK----------ENSRKL 513
L+E + LE R + + S+ E+ EAL++ K L+ E SR L
Sbjct: 1935 LKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSL 1994
Query: 514 EEENENLRAELQCC---STQLESSLNKYNTSQQVIQDLNKEIALQKESLMSLQAQLDKAL 570
E L+A L C S QLE +L + IQD + + L AQ D+ L
Sbjct: 1995 EASTATLQASLDACQAHSRQLEEALR---IQEGEIQDQDLRYQEDVQQLQQALAQRDEEL 2051
Query: 571 QKEKHYLQTTITKEAYDALSRKSAA--CQDDLTQALEKLNHVTSET--KSLQQSLTQTQE 626
+ ++ Q L KS A Q+++ Q + L E + L QS+ + Q
Sbjct: 2052 RHQQEREQ----------LLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQL 2101
Query: 627 KKAQLEEEIIAYEERMKKLNTELR--------------KLRGFHQESELEVHAFDKKLEE 672
AQ E+EI+ E ++ N E KL + E+ L +
Sbjct: 2102 TLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSLEPRLQRELERLQAALRQ 2161
Query: 673 MSCQVLQWQKQHQNDLKMLAAKEEQLREFQEEMAALKENLLEDDKEPCCLPQWSVPKDTC 732
+ ++W+++ Q+ LA + + QE L+ ++LE D E L +D
Sbjct: 2162 TEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRL------QDEL 2215
Query: 733 RLYRGNDQIMTNLEQWAKQQKVANEKLGNQLREQVKYIAKLSGEKDREPTRASSPNTTRP 792
L R E+ + +LG++ EQ + ++SG + EP+ P
Sbjct: 2216 ELTRR----ALEKERLHSPGATSTAELGSR-GEQGVQLGEVSG-VEAEPS---------P 2260
Query: 793 SSPSHSHLHSVMVHLQQENKKLKKEIEEKKMKAENTRLCTKALGPSRTESTQREK 847
+ HLQQ +L EI+ +++ N +L S E +RE+
Sbjct: 2261 DGMEKQSWRQRLEHLQQAVARL--EIDRSRLQRHNVQL------RSTLEQVERER 2307
Score = 103 bits (256), Expect = 9e-22
Identities = 179/825 (21%), Positives = 341/825 (41%), Gaps = 141/825 (17%)
Query: 11 KLHLAQEQLALAGDKIASLERSLNLYRDKYQSSLSNIELLECQVKMLQGELGGIMGQEPE 70
KL E LAL DK+ ++ L L ++ QS S +E E LQ +L +
Sbjct: 600 KLSALNEALAL--DKVGLNQQLLQL-EEENQSVCSRMEAAEQARNALQVDLAEAEKRREA 656
Query: 71 --NKGDHSKVRIYTSP-----------CMIQEHQETQKRLSEVWQK----VSQQDDLIQE 113
K H + ++ + + +E +E QK+LSE + +Q + L QE
Sbjct: 657 LWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQE 716
Query: 114 LRNKLACSNALVLEREKALIKLQADFASCTATHRYPPSSSEECEDIKKILKHLQEQKDSQ 173
+ + V E+E + + A A R +E+ + L +E +S
Sbjct: 717 AKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQG----LSSAKELLESS 772
Query: 174 CLHVEEYQNLVK----DLRVELEAVSEQKRNIMKDM--MKLELDLHGLREETSAHIERKD 227
++ ++++ L V+++ V++ K I ++ +KLELD E + A ER
Sbjct: 773 LFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDT----ERSQAEQERDA 828
Query: 228 KDITILQCRLQEL----QLEFTETQKLTLKKDKFLQEKDEMLQELEKKLTQVQNSLLKKE 283
+ Q + Q + +++ ++K+ +E+ QEL K L ++ ++ E
Sbjct: 829 AARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELE 888
Query: 284 KELEKQQCMATELE--MTVKEAKQDKSKEAECKALQAEVQKLKNSLEEAKQQERL----A 337
L++QQ TE+E +E ++ +++ A C+ +Q E +K + SL E Q + A
Sbjct: 889 MRLKEQQ---TEMEAIQAQREEERTQAESALCQ-MQLETEKERVSLLETLLQTQKELADA 944
Query: 338 AQQAAQCKEEAALAGCHLEDTQRKLQKGLL-LDKQKADTIQELQRELQMLQKESSMAEKE 396
+QQ + +++ + ++T LQ L ++ + ++ + +L LQ+ESS ++
Sbjct: 945 SQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQD 1004
Query: 397 QTSNRKRVEELSLELSEALRKLENSDKEKRQLQKTVAEQDMKMNDMLDRIKHQHREQGSI 456
+ +K+VE+L +L D +R +++ V E+ + + K RE+ S+
Sbjct: 1005 KMDLQKQVEDLKSQLVA-------QDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASL 1057
Query: 457 KCKLEED------LQEATKLLEDK----REQLKKSKEHEKLMEGELEALRQEFKKKDKTL 506
L E LQEA + + + R+ +++++ +K + ++E LRQE K+K+
Sbjct: 1058 TLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADF 1117
Query: 507 KENSRKLEEENE---------------------NLRAELQCCSTQLESSLNK-------- 537
+L EE E L+ L+ +QLE+ +
Sbjct: 1118 LAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQ 1177
Query: 538 --------YNTSQQVI------------------------QDLNKEIALQKESLMSLQAQ 565
Y+ QQ + D N +L K + L A
Sbjct: 1178 AQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPL-LTAL 1236
Query: 566 LDKALQKEKHYLQTTI--TKEAYDALSRKSAACQDDLTQALEKLNHVTSETKSLQQSLTQ 623
+A+ H L + T++ D L + ++ LT + + V +E + LQ+ L+Q
Sbjct: 1237 SAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQ 1296
Query: 624 TQEKKAQ-------LEEEIIAYEERMKKLNTELRKLRGFHQESELEVHAFDKKLEEMSCQ 676
QE+K++ LE E++ E M L + LR+ E++ E E ++ Q
Sbjct: 1297 NQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQ 1356
Query: 677 VLQWQK---QHQNDLKMLAAKEEQLREFQEEMAALKENLLEDDKE 718
V Q + + EE LR + + LK +E ++E
Sbjct: 1357 VEHLQAAVVEARAQASAAGILEEDLRTARSAL-KLKNEEVESERE 1400
Score = 102 bits (254), Expect = 2e-21
Identities = 166/808 (20%), Positives = 357/808 (44%), Gaps = 67/808 (8%)
Query: 39 KYQSSLS-NIELLECQVKMLQGELGGIMGQEPEN----KGDHSKVRIYTSPCMIQEHQET 93
++++SLS N + + ++ + ++ +M +E +N G + + + +S ++Q+
Sbjct: 325 EHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGHENSLELDSSIFSQFDYQDA 384
Query: 94 QKRLSEVWQKVSQQDDLIQELRNKLA-CSNALVLEREKALIKLQADFASCTATHRYPPSS 152
K L+ V ++++ +Q+LR +LA C A+ L +++ Q + R +
Sbjct: 385 DKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQ---HDQWEEEGKALRQRLQKLT 441
Query: 153 SEECEDIKKILKHLQEQKDSQCLHVEEYQNLVKDLRVELEAVSEQKRNIMKDMMKLELDL 212
E + + LQ + DS E Q ++LR +LE + ++ + + + +EL L
Sbjct: 442 GER-DTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRR--VNVELQL 498
Query: 213 HGLREETSAHIERKDKDITILQC-RLQELQLEFTETQKLTLKKDKFLQEKDEMLQELEKK 271
G + ++++ + + + RLQE+ + L K+ + L E + + LE
Sbjct: 499 QGDSAQGQKEEQQEELHLAVRERERLQEMLMG------LEAKQSESLSELITLREALES- 551
Query: 272 LTQVQNSLLKKEKELEKQQCMATELEMTVKEAKQDKSKEAECKALQAEVQKLKNSLEEAK 331
+ ++ LL++E + E +A + + + + + + E L+A KL ++L EA
Sbjct: 552 -SHLEGELLRQE-QTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKL-SALNEAL 608
Query: 332 QQERLAAQQAAQCKEEAALAGCHLEDTQRKLQKGLLLDKQKADTIQE--------LQREL 383
+++ Q EE + C + + + L +D +A+ +E L+ +L
Sbjct: 609 ALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQL 668
Query: 384 QMLQKESSMAEKEQTSNRKRVEELSLELSEALRKLENSDKEKRQLQKTVAEQDMKMNDML 443
Q ++ + + + ++ EE+ +LSE+ + E + + QL + Q+ ++L
Sbjct: 669 QKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQE----EVL 724
Query: 444 DRIKHQHREQGSIKCKLEEDLQEATKLLEDKREQLKKSKEHEKLMEGELEALRQEFKKKD 503
R + K LE LQ + +D EQL+ ++L+E L +Q+ +
Sbjct: 725 ARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIE 784
Query: 504 KT---LKENSRKLEEENENLRAELQCCSTQLESSLNKYNTSQQVIQDLNKEIALQKESLM 560
T L+ + + + E ++ E++C +L++ ++ ++Q +++A ++
Sbjct: 785 VTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQ---AEQERDAAARQLAQAEQEGK 841
Query: 561 SLQAQLDKALQKEKHYLQTTITKEAYDALSRKSAACQDDLTQALEKLNHVTSETK-SLQQ 619
+ Q A +KE + L+ KE + Q +L +ALE L E + L++
Sbjct: 842 TALEQQKAAHEKEVNQLREKWEKE--------RSWHQQELAKALESLEREKMELEMRLKE 893
Query: 620 SLTQTQEKKAQLEEEIIAYEERMKKLNTELRKLRGFHQESELEVHAFDKKLEEMSCQVLQ 679
T+ + +AQ EEE E + ++ E K R E+ L+ K+L + S Q+
Sbjct: 894 QQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQT---QKELADASQQL-- 948
Query: 680 WQKQHQNDLKMLAAKEEQL-----REFQEEMAALKENLLE--DDKEPCCLPQWSVPKDTC 732
++ + D+K+ KE++ + QE LKE + DD S+ +D
Sbjct: 949 --ERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKM 1006
Query: 733 RLYRGNDQIMTNLEQWAKQQKVANEKLGNQLREQVKYIAKLSGEKDREPTRASSPNTTRP 792
L + + + + L Q++ +++ +LRE +Y ++ E +RE +AS +
Sbjct: 1007 DLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEY-NRIQKELERE--KASLTLSLME 1063
Query: 793 SSPSHSHLHSVMVHLQQENKKLKKEIEE 820
L QQE L+++++E
Sbjct: 1064 KEQRLLVLQEADSIRQQELSALRQDMQE 1091
Score = 97.8 bits (242), Expect = 4e-20
Identities = 137/678 (20%), Positives = 286/678 (42%), Gaps = 97/678 (14%)
Query: 10 EKLHLAQEQLALAGDKIASLERSLNLYRDKYQSSLSN----IELLECQVKMLQGELGGIM 65
+++ + Q+QL A ++ E+SL D+ Q +L+ +E L+ + + QG+ +
Sbjct: 1778 QEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVK 1837
Query: 66 GQEPENKG--DHSKVRIYTSPCMIQEHQETQKRLSEVWQKVSQQDDLIQELRNKLACSNA 123
+ +G + + + + +Q+H+E +RL E +++ + +Q L L A
Sbjct: 1838 EKADALQGALEQAHMTLKERHGELQDHKEQARRLEE---ELAVEGRRVQALEEVLGDLRA 1894
Query: 124 LVLEREKALIKLQADFASCTATHRYPPSSSEECE-DIKKILKHLQEQKDSQCLHVEEYQN 182
E+EKAL+ LQ A H + ++ + +LK ++ ++ + ++
Sbjct: 1895 ESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRH 1954
Query: 183 LVKDLRVELEAVSE-----------------QKRNIMKDMMKLELDLHGLREETSAHIER 225
+ R EA+ E ++ + + + L + AH +
Sbjct: 1955 QEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQ 2014
Query: 226 KDKDITILQCRLQELQLEFTET----QKLTLKKDKFLQEKDEMLQELEKKLTQ-VQNSLL 280
++ + I + +Q+ L + E Q+ ++D+ L+ + E Q LEK L Q VQ +++
Sbjct: 2015 LEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMI 2074
Query: 281 KKEKELEKQQCMATELEMTVKEAKQDKSKEAECKALQAEVQKLKNSLEEAKQQERLAAQQ 340
++++ L +++ +E E + L V++L+ +L + K+QE L ++
Sbjct: 2075 QEKQNLGQER------------------EEEEIRGLHQSVRELQLTLAQ-KEQEILELRE 2115
Query: 341 AAQCKEEAALAGCHLEDTQRKLQKGLLLDKQKADTIQELQRELQMLQKESSMAEKEQTSN 400
Q AL H T ++ L LD + LQREL+ LQ E +
Sbjct: 2116 TQQRNNLEALP--HSHKTSPMEEQSLKLDSLEP----RLQRELERLQAALRQTEAREIEW 2169
Query: 401 RKRVEELSLELSEALRKLENSDKEKRQLQKTVAEQDMKMNDMLDRI---------KHQHR 451
R++ ++L+L L++ + + + LQ +V E+D + + D + + H
Sbjct: 2170 REKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRRALEKERLHS 2229
Query: 452 EQGSIKCKLEEDLQEATKLLE------------DKREQLKKSKEHEKLMEGELEALRQEF 499
+ +L ++ +L E +++ ++ EH + LE R
Sbjct: 2230 PGATSTAELGSRGEQGVQLGEVSGVEAEPSPDGMEKQSWRQRLEHLQQAVARLEIDRSRL 2289
Query: 500 KKKDKTLKENSRKLEEENENLRAELQCCSTQLESSLNKYNTSQQVIQDLN-------KEI 552
++ + L+ ++E E L+ E + ++K S QD K +
Sbjct: 2290 QRHNVQLRSTLEQVERERRKLKREAMRAAQAGSLEISKATASSPTQQDGRGQKNSDAKCV 2349
Query: 553 ALQKESLMSLQAQLDKALQKEKHYLQTTITKEAYDALSRKSAACQDDLTQAL------EK 606
A ++ ++ LQAQL ++++ Y IT+ A SR+ A L+ +L +
Sbjct: 2350 AELQKEVVLLQAQLTLERKQKQDY----ITRSA--QTSRELAGLHHSLSHSLLAVAQAPE 2403
Query: 607 LNHVTSETKSLQQSLTQT 624
+ +ET+ L +SLTQ+
Sbjct: 2404 ATVLEAETRRLDESLTQS 2421
Score = 97.1 bits (240), Expect = 7e-20
Identities = 181/866 (20%), Positives = 356/866 (41%), Gaps = 174/866 (20%)
Query: 91 QETQKRLSEVWQKVSQQDDLIQELRNKLACS-----------NALVLEREKALIKLQADF 139
Q+ ++RL++ + SQ +Q+L+ +L+ + N+L E L++L
Sbjct: 1267 QKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSL----ESELMELHETM 1322
Query: 140 ASCTATHRYPPSSSEECEDIKKILKHLQEQKDSQCLHVEEYQNLVKDLRVELEAVSEQKR 199
AS + R E + +++L+ +E +Q VE Q V + R + A
Sbjct: 1323 ASLQSRLRRAELQRMEAQGERELLQAAKENLTAQ---VEHLQAAVVEARAQASAAGI--- 1376
Query: 200 NIMKDMMKLELDLHGLREETSAHIERKDKDITILQCRLQELQLEFTETQKLTLKKDKFLQ 259
LE DL R ++ K++++ + R Q LQ E +L + + K LQ
Sbjct: 1377 --------LEEDLRTARSA----LKLKNEEVESERERAQALQ----EQGELKVAQGKALQ 1420
Query: 260 EK----DEMLQELEKKLTQVQNSLLKKEKELEKQQCMATELEMTVKEAKQD----KSKEA 311
E + L E E+++ ++ + + EK+ E Q+ L + +K+ Q+ + +
Sbjct: 1421 ENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQ 1480
Query: 312 ECKALQAEVQKLKNSLEEAKQQERLAAQQAAQCKEEAALAGCHLEDTQRKLQKGLLLDKQ 371
E + ++ ++ L +++E +Q+ + +Q + +++ +TQR + + LL+ +
Sbjct: 1481 ELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKD--------RETQRNVLEHQLLELE 1532
Query: 372 KADT--------IQELQRELQML-----------------QKESSMAEKEQTSNRKRVEE 406
K D +Q+L+++L L QK E ++ + R +
Sbjct: 1533 KKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTH 1592
Query: 407 LSLELSEALRKLENSDKEKRQLQ-------KTVAEQDMKMNDMLDRIKHQHREQGSIKCK 459
L+L+L E ++L+ + L+ + + E+D ++ ++I+ R++ +
Sbjct: 1593 LTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQD 1652
Query: 460 LEEDLQE-----------------ATKLLEDKREQLKKS--------------------- 481
LE QE TK+LE+ EQ+K S
Sbjct: 1653 LERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEE 1712
Query: 482 -KEHEKLMEGELEALRQEFKKKDKTL---KENSRKLEEENENLRAELQCCSTQL-ESSL- 535
K K G LE ++ + K+K + +E+ +L+E + L +LQ ++ E+SL
Sbjct: 1713 GKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLL 1772
Query: 536 -----NKYNTSQQVIQDLNKEIALQKESLMSLQAQLDKALQKEKHYLQTTITKEAYDALS 590
+ QQ +Q+ ++ L+++SL S + +AL + L+ + +E A
Sbjct: 1773 LSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELE-ALQQEQQQAQG 1831
Query: 591 RKSAACQ--DDLTQALEKLNHVTSETKSLQQSLTQTQEKKAQLEEEIIAYEERMKKLNTE 648
++ + D L ALE+ H+T K L +E+ +LEEE+ R++ L
Sbjct: 1832 QEERVKEKADALQGALEQA-HMT--LKERHGELQDHKEQARRLEEELAVEGRRVQALEEV 1888
Query: 649 LRKLRGFHQESELEVHAFDKKL------EEMSCQVLQ--W------QKQHQNDLKMLAAK 694
L LR +E E + A ++ E+ + LQ W K+ +L+ L A+
Sbjct: 1889 LGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAE 1948
Query: 695 EEQLREFQEEMAALKENLLE---------DDKEPCCLPQ----WSVPKDTCRLYRGNDQI 741
+ R +E A E L E KE L Q S+ T L D
Sbjct: 1949 SQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDAC 2008
Query: 742 MTNLEQWAKQQKVANEKLGNQ---LREQVKYIAKLSGEKDREPTRASSPNTTRPSSPSHS 798
+ Q + ++ ++ +Q +E V+ + + ++D E R S
Sbjct: 2009 QAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQE----REQLLEKS 2064
Query: 799 HLHSVMVHLQQENKKLKKEIEEKKMK 824
V ++ QE + L +E EE++++
Sbjct: 2065 LAQRVQENMIQEKQNLGQEREEEEIR 2090
Score = 93.2 bits (230), Expect = 9e-19
Identities = 156/762 (20%), Positives = 323/762 (42%), Gaps = 88/762 (11%)
Query: 6 ENTGEKLHLAQEQLALAGDKIASLERSLNLYRDKYQSSLSNIEL--------LECQVKML 57
E+ + L ++L L ++I LE + L I+L L Q +++
Sbjct: 1647 EHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLM 1706
Query: 58 QGELGGIMGQEPENKG--DHSKVRIYTSPCMIQEHQETQKRLSEVWQKVSQQDDLIQELR 115
Q G +G +H K+ + ++ QE L E+ ++ QQ +Q L
Sbjct: 1707 QERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQ---LQGLH 1763
Query: 116 NKLACSNALVLEREKALIKLQADFASCTATHRYPPSSSE-ECEDIKKILKHLQEQKDSQC 174
K+ ++ L+ +RE+ ++ LQ S + + ++ ++ L Q ++ +
Sbjct: 1764 RKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALA--QRDQELEA 1821
Query: 175 LHVEEYQNLVKDLRVE-----LEAVSEQKRNIMKDMMKLELDLHGLREETSAHIERKDKD 229
L E+ Q ++ RV+ L+ EQ +K+ HG ++ R +++
Sbjct: 1822 LQQEQQQAQGQEERVKEKADALQGALEQAHMTLKER-------HGELQDHKEQARRLEEE 1874
Query: 230 ITILQCRLQELQLEFTETQKLTLKKDKFL----QEKDEMLQELEKKLTQVQNSLLKKEKE 285
+ + R+Q L+ + + + +++K L Q+ E QE E + +Q+S L+ +
Sbjct: 1875 LAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAV 1934
Query: 286 LEKQQCMATELEMTVKEAK----QDKSKEAECKALQAEVQKLKNSLEEAKQQ-----ERL 336
L+++ ELE E++ Q+++ A +ALQ + K +L+ +Q E
Sbjct: 1935 LKERD---QELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELS 1991
Query: 337 AAQQAAQCKEEAALAGCHLEDTQRKLQKGLLLDKQKADTIQELQRELQMLQKESSMAEKE 396
+ +A+ +A+L C R+L++ L + + + Q+L+ + + Q + ++A+++
Sbjct: 1992 RSLEASTATLQASLDACQAHS--RQLEEALRIQEGEIQD-QDLRYQEDVQQLQQALAQRD 2048
Query: 397 QTSNRKRVEELSLELSEALRKLENSDKEKRQLQKTVAEQDMKMNDMLDRIKHQHREQGSI 456
+ ++ E LE S A R EN +EK+ L + E++ I+ H+ +
Sbjct: 2049 EELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEE---------IRGLHQSVREL 2099
Query: 457 KCKLEEDLQEATKLLEDKR----EQLKKSKEHEKLMEG--ELEALRQEFKKKDKTLKENS 510
+ L + QE +L E ++ E L S + + E +L++L +++ + L+
Sbjct: 2100 QLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSLEPRLQRELERLQAAL 2159
Query: 511 RKLEEENENLRAELQCCSTQLESSLNKYNTSQQVIQDLNKEIALQKESLMSLQAQLD--- 567
R+ E R + Q + L + ++ Q+V L + + LQ +L+
Sbjct: 2160 RQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTR 2219
Query: 568 KALQKEK-HYLQTTITKEAYDA------LSRKSAACQDDLTQALEKLNHVTSETKSLQQS 620
+AL+KE+ H T T E L S + +EK + + LQQ+
Sbjct: 2220 RALEKERLHSPGATSTAELGSRGEQGVQLGEVSGVEAEPSPDGMEKQSW-RQRLEHLQQA 2278
Query: 621 LTQTQEKKAQLEEEIIAYEERMKKLNTELRKLR----GFHQESELEVHAFDKKLEEMSCQ 676
+ + + +++L+ + ++++ E RKL+ Q LE+ K S
Sbjct: 2279 VARLEIDRSRLQRHNVQLRSTLEQVERERRKLKREAMRAAQAGSLEI----SKATASSPT 2334
Query: 677 VLQWQKQHQNDLKMLAAKEEQLREFQEEMAALKENLLEDDKE 718
+ Q +D K +A E Q+E+ L+ L + K+
Sbjct: 2335 QQDGRGQKNSDAKCVA-------ELQKEVVLLQAQLTLERKQ 2369
Score = 80.9 bits (198), Expect = 5e-15
Identities = 156/715 (21%), Positives = 293/715 (40%), Gaps = 85/715 (11%)
Query: 183 LVKDLRVELEAVSEQKRNIMK----DMMKLEL-----DLHGLREETSAHIERKDKDITIL 233
L K +E EA + I D+ K EL +L L ++ E +K I L
Sbjct: 250 LAKTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKAL 309
Query: 234 QCRLQELQLEFTETQKLTLKKDKFLQEKDEMLQELEKKLTQVQNSLLKKEKELEKQQCMA 293
+ ++ L+ TE + + QE+ LQ++ K +TQV ++++ + +
Sbjct: 310 RETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQV---MVEEGDNIAQGSGHE 366
Query: 294 TELEMTVKEAKQDKSKEAECKAL----------QAEVQKLKNSLEEAKQQERLAAQQAAQ 343
LE+ Q ++A+ KAL + VQ L+ L ++ L QQ Q
Sbjct: 367 NSLELDSSIFSQFDYQDAD-KALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQ 425
Query: 344 CKEEAALAGCHLEDT--QRKLQKGLLLDKQ-KADTI-----------QELQRELQMLQKE 389
+EE L+ +R G +D Q + D++ +EL+++L++L++E
Sbjct: 426 WEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQE 485
Query: 390 SSMAEKEQTSNRKRVEELSLELSEALRKLENSDKEKRQLQKTVAEQDMKMNDML------ 443
+ + + + + + E +L + +E+ +LQ+ + + K ++ L
Sbjct: 486 AWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITL 545
Query: 444 -DRIKHQHREQGSIKCKLEEDLQEATKLLEDKREQLKKSKEHEKLMEGELEALRQEFKKK 502
+ ++ H E G + + + ++ A E +L S+ K +L A +
Sbjct: 546 REALESSHLE-GELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSAL 604
Query: 503 DKTLKENSRKLEEENENLRAELQCCSTQLESSLNKYNTSQQVIQDLNKEIALQKESLMSL 562
++ L + L ++ L E Q +++E++ N Q + + K E L
Sbjct: 605 NEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHL 664
Query: 563 QAQLDKALQKEKHYLQTTI--TKEAYDALSRKSAACQDDLTQALEKLNHVTSETKSLQQS 620
+AQL KA ++ LQ + +E + + +K + + A +L + E K ++
Sbjct: 665 EAQLQKA-EEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEV 723
Query: 621 LTQTQEKKAQLEEEIIAYEERMKKLNTE----LRKLRGFHQESE-LEVHAFDKKLEEMSC 675
L + ++K L E A E R++ + + +L+G E LE F+ + +
Sbjct: 724 LARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVI 783
Query: 676 QVLQWQKQHQNDLKMLAAKEEQLREFQEEMAALKENLLEDDKEPCCLPQWSVPKDTC--R 733
+V + Q + Q + AKE Q E+ LK LE D E Q +D +
Sbjct: 784 EVTKGQLEVQIQ-TVTQAKE----VIQGEVRCLK---LELDTE---RSQAEQERDAAARQ 832
Query: 734 LYRGNDQIMTNLEQWAKQQKVANEKLGNQLREQVKYIAKLSGEKDREPTRASSPNTTRPS 793
L + + T LE QQK A+EK NQLRE+ EK+R +
Sbjct: 833 LAQAEQEGKTALE----QQKAAHEKEVNQLREK--------WEKERSWHQQELAKALESL 880
Query: 794 SPSHSHLHSVMVHLQQENKKLKKEIEEKKMKAENTRLCTKALGPSRTESTQREKV 848
L + Q E + ++ + EE++ +AE+ LC L T++E+V
Sbjct: 881 EREKMELEMRLKEQQTEMEAIQAQREEERTQAESA-LCQMQL------ETEKERV 928
Score = 42.0 bits (97), Expect = 0.003
Identities = 73/364 (20%), Positives = 145/364 (39%), Gaps = 50/364 (13%)
Query: 368 LDKQKADTIQELQRELQMLQKESSMAEKEQTSNRK--RVEELSLELSEALRKLENSDKEK 425
L+ K ++Q L E Q+L + MAE + S RK +E + +RKL+ +
Sbjct: 8 LNNMKPQSLQ-LVLEEQVLALQQQMAENQAASWRKLKNSQEAQQRQATLVRKLQAKVLQY 66
Query: 426 R----QLQKTVAEQDMKMNDMLDRIKHQHREQGSIKCKLEEDLQEATKLLE---DKREQL 478
R +L+K + + + ++ + ++ + +LEE+ Q L E R +
Sbjct: 67 RSWCQELEKRLEATGGPIPQRWENVEEPNLDE--LLVRLEEEQQRCESLAEVNTQLRLHM 124
Query: 479 KKSKEHEKLMEGELEALRQEFKKKDKTLKENSRKLEEENENLRAELQCCSTQLESSLNKY 538
+K+ K + ++E L ++ + L + + E E + L+ +L S
Sbjct: 125 EKADVVNKALREDVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLLS----- 179
Query: 539 NTSQQVIQDLNKEIALQKESLMSLQAQLDKALQKEKHYLQTTITKEAYDALSRKSAACQD 598
L +E+ + + +++ D+ L + K + LS C
Sbjct: 180 ---------LWREVVTFRRHFLEMKSATDRDLME---------LKAEHVRLSGSLLTCCL 221
Query: 599 DLTQALEKLNHVTSETKSLQQSLTQTQEKKAQLEEEIIAYEERMKKLNTELRKLRGFHQE 658
LT V ++++ S + AQL + +E K+ + ++L +
Sbjct: 222 RLT--------VGAQSREPNGSGRMDGREPAQLLLLLAKTQELEKEAHERSQELIQLKSQ 273
Query: 659 SELEVHAFDKKLEEMSCQVLQWQKQHQNDLKMLAAKEEQLR-------EFQEEMAALKEN 711
+LE ++ E+S + Q QKQ+++ KM+ A E + E E A+L N
Sbjct: 274 GDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRETVEILETNHTELMEHEASLSRN 333
Query: 712 LLED 715
E+
Sbjct: 334 AQEE 337
>gi|87298937 centrosomal protein 110kDa [Homo sapiens]
Length = 2325
Score = 121 bits (304), Expect = 2e-27
Identities = 184/802 (22%), Positives = 355/802 (44%), Gaps = 144/802 (17%)
Query: 85 CMIQEHQETQKRLSEVWQKVSQQDDLIQELRNKLACSNALVLEREKALIKLQADFASCTA 144
C + EH + +VS+ +D++Q L++K +RE+ ++ A
Sbjct: 1313 CNVPEHHNLEN-------EVSRLEDIMQHLKSK---------KREERWMR---------A 1347
Query: 145 THRYPPSSSEECEDIKKILKHLQEQKDSQCLHVEEYQNLVKDLRVELEAVSEQKRNIMKD 204
+ R S +E E++ + L ++K S VEE V+ + + + + N+
Sbjct: 1348 SKR---QSEKEMEELHHNIDDLLQEKKSLECEVEELHRTVQKRQQQKDFIDG---NVESL 1401
Query: 205 MMKLELDLHGLREETSAHIERKDKDITILQCRLQELQLEFTETQKLTLKKDKFLQEKDEM 264
M +LE+ E++ H E +I ++ L + + E E +L + + L E
Sbjct: 1402 MTELEI------EKSLKHHEDIVDEIECIEKTLLKRRSELREADRLLAEAESELSCTKEK 1455
Query: 265 LQELEKKLTQVQNSLLKKEKELEKQQCMATELEMTVKEAKQDKSKEAECKALQAEVQKLK 324
+ +K T + SLL+ E + E+ + A E + + +A Q + ++LQA+ + L+
Sbjct: 1456 TKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVKADQ------QLRSLQADAKDLE 1509
Query: 325 NSLEEAKQQERLAAQQAAQCKEEAALAGCHLEDTQRKLQKGLLLDKQKADTIQELQRELQ 384
+ KQ+E L KE + D Q L K+K ++L ELQ
Sbjct: 1510 Q--HKIKQEEIL--------KEINKIVAAKDSDFQ-------CLSKKK----EKLTEELQ 1548
Query: 385 MLQKESSMAEKEQTSNRKRVEELSLELSEALRKLENSDKEKRQLQKTVAEQDMKMND-ML 443
LQK+ MAE+ + + + ++E SE L + + ++ EK + Q T +Q+M + D L
Sbjct: 1549 KLQKDIEMAERNEDHHLQVLKE-----SEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQL 1603
Query: 444 DRIKHQ-HREQGSIKCKLEEDLQEATKLLE-DKREQLKKSKEHEKLME------GELEAL 495
K + H QGS+ + + DLQEA +L E + E+ +E + L+E GEL
Sbjct: 1604 GHKKEELHLLQGSM-VQAKADLQEALRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQ 1662
Query: 496 RQEFKKKDKTLKENSRKLEEENENLRAELQCCSTQLESSLNKYNTSQQVIQDLNKEIALQ 555
E K + +K+ ++E+E ENL+ L+ ++K+ T + I D+ + L+
Sbjct: 1663 ISERKTQLTLIKQ---EIEKEEENLQVVLR--------QMSKHKTELKNILDM---LQLE 1708
Query: 556 KESLMSLQAQLDKALQK----EKHYLQTTITKEAYDALSRKSAACQDDLTQALEK----L 607
L L+ Q D+ + + + L+ + E +S++ + Q LE+ +
Sbjct: 1709 NHELQGLKLQHDQRVSELEKTQVAVLEEKLELENLQQISQQQKGEIEWQKQLLERDKREI 1768
Query: 608 NHVTSETKSLQQSLTQTQEKKAQLEEEIIAYEERMKKLNTELRKLRGFHQESELEVHAFD 667
+T+E+++LQ + ++K L+E+ +E KKL R L + S++E +
Sbjct: 1769 ERMTAESRALQSCVECLSKEKEDLQEKCDIWE---KKLAQTKRVLAAAEENSKMEQSNLE 1825
Query: 668 K------KLEEMSCQVLQWQKQHQNDL----KMLAAKEEQLREFQEEMAALKE--NLLED 715
K KL++ Q+ + + ND+ + L K E + QEE+A +++ NL +
Sbjct: 1826 KLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQ 1885
Query: 716 DKEPCCLPQWSVPKDTCRLYRGNDQIMTNLEQWAKQQKVANEKL--------GNQLR--E 765
D Q + + RL + + E K+++ ++L N+L+ +
Sbjct: 1886 DLLHTTKHQDVLLSEQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQ 1945
Query: 766 QVKYIAKLSGEKDREPTRASSPNTTRPSSPSHSHLHSVMVHLQQENKKLKKEIEEKKMKA 825
Q +L E++ E S L + V L+++ +L+KE+ ++K K
Sbjct: 1946 QEMMFQRLQKERESE----------------ESKLETSKVTLKEQQHQLEKELTDQKSKL 1989
Query: 826 ENTRLCTKALGPSRTESTQREK 847
+ ++ +K L T +E+
Sbjct: 1990 D--QVLSKVLAAEERVRTLQEE 2009
Score = 99.8 bits (247), Expect = 1e-20
Identities = 149/668 (22%), Positives = 286/668 (42%), Gaps = 70/668 (10%)
Query: 18 QLALAGDKIASLERSLNLY---RDKYQSSLSNI-ELLECQVKMLQGELGGIMGQEPENKG 73
QL L +I E +L + K+++ L NI ++L+ + LQG + + ++
Sbjct: 1669 QLTLIKQEIEKEEENLQVVLRQMSKHKTELKNILDMLQLENHELQGLK--LQHDQRVSEL 1726
Query: 74 DHSKVRIYTSPCMIQEHQE-TQKRLSEV-WQKVSQQDD------LIQELRNKLACSNALV 125
+ ++V + ++ Q+ +Q++ E+ WQK + D + E R +C L
Sbjct: 1727 EKTQVAVLEEKLELENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQSCVECLS 1786
Query: 126 LERE----------KALIKLQADFASCTATHRYPPSSSEECE-DIKKILKHLQE-QKDSQ 173
E+E K L + + A+ + S+ E+ E +++K+ + L + +D
Sbjct: 1787 KEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKL 1846
Query: 174 CLH--VEEYQNLVKDLRVELEAVSEQKRNIMKDMMKLELDLHGLREETSAHIERKDKDIT 231
LH + Q +++ R + ++ E+ N+ + + DL T+ H + + T
Sbjct: 1847 SLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLL----HTTKHQDVLLSEQT 1902
Query: 232 ILQCRLQELQLEFTETQKLTLKKDKFLQEKDEMLQELEKKLTQVQNSLLKKEKELEKQQC 291
LQ + E F + QK K + LQ ++E + KL Q + + +KE E ++
Sbjct: 1903 RLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEES 1962
Query: 292 MATELEMTVKEAKQDKSKEAECKALQAEVQKLKNSLEEAKQQERLAAQQAAQCKEEAALA 351
++T+KE Q E E ++++ ++ + + A+++ R ++ C+
Sbjct: 1963 KLETSKVTLKE--QQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESLEKT- 2019
Query: 352 GCHLEDTQRKLQKGLLLDKQKADTIQELQRELQMLQKESSMAEKEQTSNRKRVEELSLEL 411
L T+R+L + +K+ + LQ+E ++ + S+ + + RK+ E+ L
Sbjct: 2020 ---LSQTKRQLSEREQQLVEKSGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVASL 2076
Query: 412 SEALR----KLENSDKEKRQ----LQKTVAEQDMKMNDMLDRIKHQHREQGSIKCKLEED 463
EAL+ +LE + E++Q +QK +A ++ D +R + +E ++ + E
Sbjct: 2077 KEALKIQRSQLEKNLLEQKQENSCIQKEMATIELVAQDNHERARRLMKELNQMQYEYTEL 2136
Query: 464 LQEATKLLEDKREQLKKSKEHEKLMEGELEALRQEFKKKDKTLKENSRKLE---EENENL 520
++ + +R Q++ S L + +R K ++ L E LE E NENL
Sbjct: 2137 KKQMANQKDLERRQMEISDAMRTLKSEVKDEIRTSLKNLNQFLPELPADLEAILERNENL 2196
Query: 521 RAELQCCSTQLESSLN------KYNTSQQVIQDLNKEIALQKESLM----SLQAQLDKAL 570
EL+ L ++N K N SQ I D + +E L L+AQL +
Sbjct: 2197 EGELESLKENLPFTMNEGPFEEKLNFSQVHIMDEHWRGEALREKLRHREDRLKAQLRHCM 2256
Query: 571 QKEKHYL-----QTTIT----KEAYDALSRKSAACQDDLTQALEKLNHVTSETKSLQQSL 621
K+ L QT T + DAL + D + +S T+ Q L
Sbjct: 2257 SKQAEVLIKGKRQTEGTLHSLRRQVDALGELVTSTSADSASSPSLSQLESSLTEDSQ--L 2314
Query: 622 TQTQEKKA 629
Q QEK A
Sbjct: 2315 GQNQEKNA 2322
Score = 97.1 bits (240), Expect = 7e-20
Identities = 157/760 (20%), Positives = 329/760 (43%), Gaps = 118/760 (15%)
Query: 10 EKLHLAQEQLALAGDKIASLERSLNLYRDKYQSSLSNIELLECQVKMLQGELGGIMGQEP 69
E+ + QE++ +KI + + S +Q E L +++ LQ ++ +
Sbjct: 1509 EQHKIKQEEILKEINKIVAAKDS------DFQCLSKKKEKLTEELQKLQKDI-----EMA 1557
Query: 70 ENKGDHSKVRIYTSPCMIQ-EHQETQKRLSEVWQKVSQQDDLIQELRNKLACSNALVLER 128
E DH + S ++Q + E +K S+V + + L ++L +K + L
Sbjct: 1558 ERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLL---- 1613
Query: 129 EKALIKLQADFASCTATHRYPPSSSEECEDIKKILKHLQE--------------QKDSQC 174
+ ++++ +AD A +E+C I+++ L+E +K
Sbjct: 1614 QGSMVQAKADLQE--ALRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQISERKTQLT 1671
Query: 175 LHVEEYQNLVKDLRVELEAVSEQK---RNIMKDMMKLEL-DLHGLREETSAHIERKDK-D 229
L +E + ++L+V L +S+ K +NI+ DM++LE +L GL+ + + +K
Sbjct: 1672 LIKQEIEKEEENLQVVLRQMSKHKTELKNIL-DMLQLENHELQGLKLQHDQRVSELEKTQ 1730
Query: 230 ITILQCRLQ--------ELQLEFTETQKLTLKKDK------------------FLQEKDE 263
+ +L+ +L+ + Q E QK L++DK L ++ E
Sbjct: 1731 VAVLEEKLELENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQSCVECLSKEKE 1790
Query: 264 MLQEL----EKKLTQVQNSLLKKEKELEKQQCMATELEMTVKEAKQDKSKEAECK-ALQA 318
LQE EKKL Q + L E+ + +Q +LE+ V++ +Q+ + K +L
Sbjct: 1791 DLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHN 1850
Query: 319 EVQKLKNSLEEAKQQERLAAQQAAQCKEEAALAGCHLEDTQRKLQKGLLLDKQKADTIQE 378
++ ++ L+E ++ ++ A ++ LA L T + + +LL +Q
Sbjct: 1851 DISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTK--HQDVLLSEQT-----R 1903
Query: 379 LQRELQMLQKESSMAEKEQTSNRKRVEELSLELSEALRKLENSDKEKRQLQKTVAEQDMK 438
LQ+++ +KE+ + +++++ L E+ E KL + ++LQK ++ K
Sbjct: 1904 LQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESK 1963
Query: 439 MNDMLDRIKHQHREQGSIKCKLEEDLQEATKLLEDKREQLKKSKEHEK---LMEGELEAL 495
+ +K Q + + L + + E+++ +E E+ +E L
Sbjct: 1964 LETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESLEKTLSQT 2023
Query: 496 RQEFKKKDKTLKENSRK---LEEENENLRAELQCCSTQLESSLNKYNTSQQVIQDLNKEI 552
+++ ++++ L E S + L++E +++RA+ Q + K K++
Sbjct: 2024 KRQLSEREQQLVEKSGELLALQKEADSMRADFSLLRNQFLTERKK----------AEKQV 2073
Query: 553 ALQKESLMSLQAQLDKALQKEKHYLQTTITKEAYDALSRKSAACQDDLTQALEKLNHVTS 612
A KE+L ++QL+K L ++K + I KE ++ QD+ E+ +
Sbjct: 2074 ASLKEALKIQRSQLEKNLLEQKQE-NSCIQKE----MATIELVAQDN----HERARRLMK 2124
Query: 613 ETKSLQQSLTQTQEKKAQLEEEIIAYEERMKKLNTELRKLRGFHQESELEVHAFDKKLEE 672
E +Q T+ +++ A ++ E R +++ +R L+ E + E+ K L
Sbjct: 2125 ELNQMQYEYTELKKQMANQKD----LERRQMEISDAMRTLK---SEVKDEIRTSLKNLN- 2176
Query: 673 MSCQVLQWQKQHQNDLKMLAAKEEQLREFQEEMAALKENL 712
Q+ + DL+ + + E L + E+ +LKENL
Sbjct: 2177 ------QFLPELPADLEAILERNENL---EGELESLKENL 2207
Score = 96.7 bits (239), Expect = 9e-20
Identities = 148/680 (21%), Positives = 287/680 (42%), Gaps = 128/680 (18%)
Query: 53 QVKMLQGELGGIMGQEPENKGDHSKVRIYTS------PCMIQEHQETQKRLSEVWQKVSQ 106
++K LQ + + ++P+ HS ++ S M +++Q+ + RL E+ ++++
Sbjct: 532 EIKDLQIAIDSLDSKDPK----HSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAK 587
Query: 107 QDDLIQELRNKL-----ACSNALVLEREKALIKLQADFASCTATHRYPPSSSEECEDIKK 161
+ + I++L +L A + AL + E + LQ + + EC
Sbjct: 588 ETEEIKDLEEQLTEGQIAANEALKKDLEGVISGLQEYLGTIKGQ---ATQAQNEC----- 639
Query: 162 ILKHLQEQKDSQCLHVEEYQNLVKDLRVELEAVSEQKRNIMKDMMKLELDLHGLREETSA 221
+ L+++K++ + E V+ R +LE V+ N+ K++ +LE L + E +A
Sbjct: 640 --RKLRDEKETLLQRLTE----VEQERDQLEIVAMDAENMRKELAELESALQE-QHEVNA 692
Query: 222 HIERKDKDITILQCRLQELQLEFTETQKLTLKKDKFLQEKDEMLQELEK--KLTQVQNSL 279
+++ D++ + L+ +L L+ E +++ +ELEK +LTQ++ S
Sbjct: 693 SLQQTQGDLSAYEAELEA---------RLNLRD----AEANQLKEELEKVTRLTQLEQSA 739
Query: 280 LKKEKELEKQQCMATELEMTVKEAKQDKSKE--AECKALQAEVQKLKNSLEEAKQQERLA 337
L+ E E E+Q + E K+ ++ E A+ K LQ + LK L++ +
Sbjct: 740 LQAELEKERQALKNALGKAQFSEEKEQENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHV 799
Query: 338 AQQAAQCKEEAALAGCHLEDTQRKLQKGL----------LLDKQKADTIQELQREL-QML 386
+ +E AA +++ +RKL+ G +L K AD LQ++ ++L
Sbjct: 800 VDGLVRPEEVAA----RVDELRRKLKLGTGEMNIHSPSDVLGKSLAD----LQKQFSEIL 851
Query: 387 QKESSMAEKEQTSNRKRVEELSLELSEAL-----------RKLE-NSDKEKRQLQKTVAE 434
+ ++ Q RK EE++L+ + R LE + +KRQ + + +
Sbjct: 852 ARSKWERDEAQVRERKLQEEMALQQEKLATGQEEFRQACERALEARMNFDKRQHEARIQQ 911
Query: 435 QDMKMNDMLDRIKHQHREQGSIKCKLEEDLQEATKLLEDKREQLKKSKEHEKLMEGELEA 494
+ +++ + + +K QG +L+E +E ++L RE KK K + + ++
Sbjct: 912 MENEIHYLQENLKSMEEIQGLTDLQLQEADEEKERILAQLRELEKKKKLEDAKSQEQVFG 971
Query: 495 LRQEFKKKDKTLKENSRKLEEENENLRAELQCCSTQLESSLNKYNTSQQVIQDLNKEIAL 554
L +E KK K + ++ +K T+ E+ +
Sbjct: 972 LDKELKKLKKAV--------------------------ATSDKLATA---------ELTI 996
Query: 555 QKESLMSLQAQLDKALQKEKHYLQTTITKEAYDALSRKSAACQDDLTQA------LEKLN 608
K+ L SL + K Q+ LQ + SRK+A DLT+A L+ L
Sbjct: 997 AKDQLKSLHGTVMKINQERAEELQEA------ERFSRKAAQAARDLTRAEAEIELLQNLL 1050
Query: 609 HVTSETKSLQQSLTQTQEKKAQLEEEIIAYEERMKKLNTELRKLRG-FHQESELEVHAFD 667
E L+ T EI E M++ TE+ +L+ F+
Sbjct: 1051 RQKGEQFRLEMEKTGVGTGANSQVLEIEKLNETMERQRTEIARLQNVLDLTGSDNKGGFE 1110
Query: 668 KKLEEMSCQVLQWQKQHQND 687
LEE++ L+ + +QND
Sbjct: 1111 NVLEEIA--ELRREVSYQND 1128
Score = 77.0 bits (188), Expect = 7e-14
Identities = 122/605 (20%), Positives = 258/605 (42%), Gaps = 112/605 (18%)
Query: 238 QELQLEFTETQKLTLKKDKFLQEKDEMLQELEKKLTQVQNSLLKKEKELEKQQCMATELE 297
++L+ + ET++L K+ +FL+E + KL N LK+E L+KQ C + +
Sbjct: 277 RDLEKKMIETEELKSKQTRFLEEIKN-----QDKL----NKSLKEEAMLQKQSCEELKSD 327
Query: 298 MTVKEAKQDKSKEAECKALQAEVQKLKNSLEEAKQQERLAA--------QQAAQCKEEAA 349
+ K K K E + +L+ L K + + + +E+
Sbjct: 328 LNTKNELL-KQKTIELTRACQKQYELEQELAFYKIDAKFEPLNYYPSEYAEIDKAPDESP 386
Query: 350 LAGCHLEDTQRKLQKGLLLDKQKADTIQELQRELQM------------LQKESSMAEKEQ 397
G + ++D +A I++++ + Q+ L + EK+
Sbjct: 387 YIGKSRYKRNMFATESYIIDSAQAVQIKKMEPDEQLRNDHMNLRGHTPLDTQLEDKEKKI 446
Query: 398 TSNRKRVEELSLELSEALRKLENSDKEKRQLQKTVAEQDMKMNDM-LDRIKHQHREQGSI 456
++ + R+ EL E+ +A +++ + +E +QL++ + Q K+++ D + Q + +
Sbjct: 447 SAAQTRLSELHDEIEKAEQQILRATEEFKQLEEAI--QLKKISEAGKDLLYKQLSGRLQL 504
Query: 457 KCKLEEDLQEATKLLEDKREQLKKSKEHEKLMEGELEALRQEFKKKDKTLKENSRKLEEE 516
KL ++ + +E +++++ ++ K ++ +++L + K + S K E++
Sbjct: 505 VNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAIDSLDSKDPKHSHMKAQKSGK-EQQ 563
Query: 517 NENLRAELQCCSTQLESSLNKYNTSQQVIQDLNKEIALQKESLMSLQAQLDKALQKEKHY 576
+ + + Q ++L+ L++ + I+DL +E L Q ++AL+K+
Sbjct: 564 LDIMNKQYQQLESRLDEILSRIAKETEEIKDL-------EEQLTEGQIAANEALKKD--- 613
Query: 577 LQTTITKEAYDALSRKSAACQDDLTQALEKLNHVTSETKSLQQSLTQTQEKKAQLEEEII 636
L+ I+ L + TQA + + E ++L Q LT+ ++++ QLE I+
Sbjct: 614 LEGVIS-----GLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQLE--IV 666
Query: 637 AYE-ERMKKLNTELRKLRGFHQESELEVHAFDKKLEEMSCQVLQWQKQHQNDLKMLAAKE 695
A + E M+K EL +L QE H + L++ + ++ + + L + A+
Sbjct: 667 AMDAENMRK---ELAELESALQEQ----HEVNASLQQTQGDLSAYEAELEARLNLRDAEA 719
Query: 696 EQLREFQEEMAALKENLLEDDKEPCCLPQWSVPKDTCRLYRGNDQIMTNLEQWAKQQKVA 755
QL+E E++ L T LEQ A Q ++
Sbjct: 720 NQLKEELEKVTRL----------------------------------TQLEQSALQAELE 745
Query: 756 NEKLGNQLREQVKYIAKLSGEKDREPTRASSPNTTRPSSPSHSHLHSVMVHLQQENKKLK 815
E+ Q + A+ S EK++E +S LH+ + HLQ +N LK
Sbjct: 746 KER---QALKNALGKAQFSEEKEQE----------------NSELHAKLKHLQDDNNLLK 786
Query: 816 KEIEE 820
+++++
Sbjct: 787 QQLKD 791
Score = 61.2 bits (147), Expect = 4e-09
Identities = 96/409 (23%), Positives = 169/409 (41%), Gaps = 58/409 (14%)
Query: 67 QEPENKGDHSKVRIYTSP--CMIQEHQETQKRLSEVWQKVSQQDDL---IQELRNKLACS 121
+E EN H+K++ + Q+ ++ Q L+ V + + +++ + ELR KL
Sbjct: 764 KEQENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEEVAARVDELRRKLKLG 823
Query: 122 NALVLERE------KALIKLQADFASCTATHRYPPSSSEECEDIKKILKHLQEQKDSQCL 175
+ K+L LQ F+ A ++ ++ E + LQE+ L
Sbjct: 824 TGEMNIHSPSDVLGKSLADLQKQFSEILARSKWERDEAQVRE------RKLQEE---MAL 874
Query: 176 HVEEYQNLVKDLRVELEAVSEQKRNIMKDMMKLELDLHGLREETSAHIERKDKDITILQC 235
E+ ++ R E E + N K + A I++ + +I LQ
Sbjct: 875 QQEKLATGQEEFRQACERALEARMNFDK-------------RQHEARIQQMENEIHYLQE 921
Query: 236 RLQELQLEFTETQKLTLKKDKFLQEKDEMLQELEKKLTQVQNSLLKKEKELEKQQCMATE 295
L+ ++ E Q LT D LQE DE E E+ L Q++ KK+ E K Q
Sbjct: 922 NLKSME----EIQGLT---DLQLQEADE---EKERILAQLRELEKKKKLEDAKSQEQVFG 971
Query: 296 LEMTVKEAKQ-----DKSKEAE-------CKALQAEVQKLKNSLEEAKQQERLAAQQAAQ 343
L+ +K+ K+ DK AE K+L V K+ E Q+ +++AAQ
Sbjct: 972 LDKELKKLKKAVATSDKLATAELTIAKDQLKSLHGTVMKINQERAEELQEAERFSRKAAQ 1031
Query: 344 CKEEAALAGCHLEDTQRKL-QKG--LLLDKQKADTIQELQRELQMLQKESSMAEKEQTSN 400
+ A +E Q L QKG L+ +K ++ ++K + E+++T
Sbjct: 1032 AARDLTRAEAEIELLQNLLRQKGEQFRLEMEKTGVGTGANSQVLEIEKLNETMERQRTEI 1091
Query: 401 RKRVEELSLELSEALRKLENSDKEKRQLQKTVAEQDMKMNDMLDRIKHQ 449
+ L L S+ EN +E +L++ V+ Q+ ++ M D K +
Sbjct: 1092 ARLQNVLDLTGSDNKGGFENVLEEIAELRREVSYQNDYISSMADPFKRR 1140
>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
sapiens]
Length = 1939
Score = 121 bits (303), Expect = 3e-27
Identities = 175/881 (19%), Positives = 383/881 (43%), Gaps = 112/881 (12%)
Query: 11 KLHLAQEQLALAGDKIASLERSLNLYRDKYQSSLSNIELLECQVKMLQGELGGIMG--QE 68
++ L + + L GD + E ++++ DK Q L+ ++K + E+ G+ ++
Sbjct: 1049 RMDLERAKRKLEGDLKLAQESTMDIENDKQQ--------LDEKLKKKEFEMSGLQSKIED 1100
Query: 69 PENKGDHSKVRIYTSPCMIQEHQE-----------TQKRLSEVWQKVSQQDDLIQELRNK 117
+ G + +I I+E +E +K+ S++ +++ + + ++E
Sbjct: 1101 EQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGA 1160
Query: 118 LACSNALVLEREKALIKLQADFASCTATHRYPPSS------------SEECEDIKKILKH 165
+ + +RE K++ D T H ++ E+ ++++++ +
Sbjct: 1161 TSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQK 1220
Query: 166 LQEQKDSQCLHVEEYQNLVKDLRVELEAVSEQKRNIMKDMMKLELDLHGLREETSAHIER 225
L+++K + ++ DL +E VS+ K N+ K LE L ++ + +R
Sbjct: 1221 LEKEKSEMKMEID-------DLASNMETVSKAKGNLEKMCRALEDQLSEIKTKEEEQ-QR 1272
Query: 226 KDKDITILQCRLQ--------ELQLEFTETQKLTLKKDKFLQEKDEMLQELEKKLTQ--- 274
D+T + RLQ +L + T +L+ K F Q+ +E+ ++LE+++
Sbjct: 1273 LINDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEELKRQLEEEIKAKSA 1332
Query: 275 ----VQNSL----LKKEKELEKQQCMATELEMTVKEAKQDKSK---EAECKALQAEVQKL 323
+Q+S L +E+ E+Q+ A EL+ + +A + ++ + E A+Q +
Sbjct: 1333 LAHALQSSRHDCDLLREQYEEEQEAKA-ELQRAMSKANSEVAQWRTKYETDAIQRTEE-- 1389
Query: 324 KNSLEEAKQQERLAAQQAAQCKEEAALAGCHLEDTQRKLQ---KGLLLDKQKADT----I 376
LEEAK++ Q A + E LE T+++LQ + L++D ++ + +
Sbjct: 1390 ---LEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAAL 1446
Query: 377 QELQRELQMLQKESSMAEKEQTSNRKRVEELSLELSEALRKLENSDKEKRQLQKTVAEQD 436
+ QR + E +E + + ++ S LS L K++N+ +E +T+ ++
Sbjct: 1447 DKKQRNFDKILAEWKQKCEETHAELEASQKESRSLSTELFKIKNAYEESLDQLETLKREN 1506
Query: 437 MKMNDMLDRIKHQHREQGSIKCKLEE---DLQEATKLLEDKREQLKKSKEHE--KLMEGE 491
+ + + Q E G +LE+ +++ L+ E+ + S EHE K++ +
Sbjct: 1507 KNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAALEEAEASLEHEEGKILRIQ 1566
Query: 492 LEALRQEFKKKDKTLKENSRKLEEENENLRAELQCCSTQLESSLNKYNTS----QQVIQD 547
LE L Q + D+ + E ++++ N ++ + L++ + N + +++ D
Sbjct: 1567 LE-LNQVKSEVDRKIAEKDEEIDQMKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGD 1625
Query: 548 LNK-EIALQKESLMSLQAQLD----KALQKEKHYLQTTITKEAYDALSRKSAACQDDLTQ 602
LN+ EI L + M+ +A + +A+ K+ T+ D R ++ L
Sbjct: 1626 LNEMEIQLNHANRMAAEALRNYRNTQAILKD--------TQLHLDDALRSQEDLKEQLAM 1677
Query: 603 ALEKLNHVTSETKSLQQSLTQTQEKKAQLEEEIIAYEERMKKLNTELRKLRGFHQESELE 662
+ N + +E + L+ +L QT+ + E+E++ ER++ L+T+ L ++ E +
Sbjct: 1678 VERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETD 1737
Query: 663 VHAFDKKLEEMSCQVLQWQKQHQNDLKMLAAKEEQLREFQEEMAAL---KENLLEDDKEP 719
+ ++E++ + +++ + + A E+L++ Q+ A L K+NL + K+
Sbjct: 1738 ISQIQGEMEDIIQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKD- 1796
Query: 720 CCLPQWSVPKDTCRLYRGNDQIMTNLEQWAKQQKVANEKLGNQLREQVKYIAKLSGEKDR 779
L + L G QI K + E G EQ + + + G +
Sbjct: 1797 --LQHRLDEAEQLALKGGKKQIQ-------KLEARVRELEGEVESEQKRNVEAVKGLRKH 1847
Query: 780 EPTRASSPNTTRPSSPSHSHLHSVMVHLQQENKKLKKEIEE 820
E T + L ++ LQ + K K++ EE
Sbjct: 1848 ERKVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEE 1888
Score = 104 bits (260), Expect = 3e-22
Identities = 142/654 (21%), Positives = 278/654 (42%), Gaps = 85/654 (12%)
Query: 267 ELEKKLTQVQNSLLKKEKELEKQQCMATELE---MTVKEAKQDKSKEAECKALQAEVQKL 323
E EK++ ++ K ++EL K + ELE +T+ + K D + +QAE L
Sbjct: 848 ETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQ-----VQAEADSL 902
Query: 324 KNSLEEAKQQERLAAQQAAQCKEEAALAGCHLEDTQRKLQKGLLLDKQKA-DTIQELQRE 382
++ E Q + Q A+ KE A + + ++ L K+K D EL+++
Sbjct: 903 ADAEERCDQLIKTKIQLEAKIKEVTERA-----EDEEEINAELTAKKRKLEDECSELKKD 957
Query: 383 LQMLQKESSMAEKEQTSNRKRVEELSLELSEALRKLENSDKEKRQLQK------------ 430
+ L+ + EKE+ + +V+ L+ E++ + KEK+ LQ+
Sbjct: 958 IDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAE 1017
Query: 431 -----TVAEQDMKMNDMLDRIKHQHREQGSI-------KCKLEEDL---QEATKLLEDKR 475
T+ + +K+ +D ++ ++ I K KLE DL QE+T +E+ +
Sbjct: 1018 EDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDK 1077
Query: 476 EQL-KKSKEHEKLMEG------ELEALRQEFKKKDKTLKENSRKLEEENENLRA------ 522
+QL +K K+ E M G + +AL + +KK K L+ +LEEE E RA
Sbjct: 1078 QQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAE 1137
Query: 523 --------ELQCCSTQLESSLNKYNTSQQVIQDLNKEIALQKE----SLMSLQAQLDKAL 570
EL+ S +LE + TS Q+ + +E QK +LQ + A
Sbjct: 1138 KQRSDLSRELEEISERLEEAGGA--TSAQIEMNKKREAEFQKMRRDLEEATLQHEATAAT 1195
Query: 571 QKEKHYLQTTITKEAYDALSRKSAACQ----------DDLTQALEKLN----HVTSETKS 616
++KH E D L R + DDL +E ++ ++ ++
Sbjct: 1196 LRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRA 1255
Query: 617 LQQSLTQTQEKKAQLEEEIIAYEERMKKLNTELRKLRGFHQESELEVHAFDKKLEEMSCQ 676
L+ L++ + K+ + + I + +L TE + E + V + + + Q
Sbjct: 1256 LEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQ 1315
Query: 677 VLQWQKQHQNDLKMLAAKEEQLREFQEEMAALKENLLEDDKEPCCLPQWSVPKDTCRLYR 736
+ + ++Q + ++K +A L+ + + L+E E+++E Q ++ K + +
Sbjct: 1316 IEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQ-YEEEQEAKAELQRAMSKANSEVAQ 1374
Query: 737 GNDQIMTNLEQWAKQQKVANEKLGNQLREQVKYIAKLSGE-KDREPTRASSPNTTRPSSP 795
+ T+ Q ++ + A +KL +L++ +++ ++ + E T+ N
Sbjct: 1375 WRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMI 1434
Query: 796 SHSHLHSVMVHLQQENKKLKKEIEEKKMKAENTRLCTKA-LGPSRTESTQREKV 848
++ L ++ + K + E K K E T +A SR+ ST+ K+
Sbjct: 1435 DVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKESRSLSTELFKI 1488
Score = 104 bits (259), Expect = 4e-22
Identities = 146/749 (19%), Positives = 305/749 (40%), Gaps = 71/749 (9%)
Query: 127 EREKALIKLQADFASCTATHRYPPSSSEECEDIKKILKHLQEQKDSQC---------LHV 177
E EK + ++ +F + +E E+ K++ +QE+ D Q
Sbjct: 848 ETEKEMANMKEEFEKTKEELAKTEAKRKELEE--KMVTLMQEKNDLQLQVQAEADSLADA 905
Query: 178 EEYQNLVKDLRVELEAVSEQKRNIMKDMMKLELDLHGLREETSAHIERKDKDITILQCRL 237
EE + + +++LEA ++ +D ++ +L + + KDI L+ L
Sbjct: 906 EERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTL 965
Query: 238 QELQLEFTETQKLTLKKDKFLQEKDEMLQELEKKLTQVQ-------NSLLKKEKELEKQQ 290
+++ E T+ + + DE + +L K+ +Q + L +E ++
Sbjct: 966 AKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLT 1025
Query: 291 CMATELEMTVKEAKQDKSKEAECKA-LQAEVQKLKNSLEEAKQQERLAAQQAAQCKEEAA 349
+LE V + + +E + + L+ +KL+ L+ A++ Q E+
Sbjct: 1026 KAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKLK 1085
Query: 350 LAGCHLEDTQRKLQKGLLLDKQKADTIQELQRELQMLQKE-------SSMAEKEQTSNRK 402
+ Q K++ L Q I+ELQ ++ L++E + AEK+++ +
Sbjct: 1086 KKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSR 1145
Query: 403 RVEELSLELSEA----LRKLENSDKEKRQLQK--------------TVAEQDMKMNDMLD 444
+EE+S L EA ++E + K + + QK T A K D +
Sbjct: 1146 ELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVA 1205
Query: 445 RIKHQHREQGSIKCKLEEDLQEATKLLED---KREQLKKSKEHEKLMEGELEALRQEFKK 501
+ Q +K KLE++ E ++D E + K+K + + M LE E K
Sbjct: 1206 ELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLSEIKT 1265
Query: 502 KDKTLKENSRKLEEENENLRAELQCCSTQLESS---LNKYNTSQQVIQDLNKEIALQKES 558
K++ + L + L+ E S QL+ +++ + +Q +E+ Q E
Sbjct: 1266 KEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEELKRQLEE 1325
Query: 559 LMSLQAQLDKALQKEKHYLQTTITKEAYDALSRKSAACQDDLTQALEKLN--HVTSETKS 616
+ ++ L ALQ +H + +E Y+ A Q +++A ++ ET +
Sbjct: 1326 EIKAKSALAHALQSSRH--DCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDA 1383
Query: 617 LQQSLTQTQEKKAQLEEEIIAYEERMKKLNTELRKLRGFHQESELEVHAFDKKLEEMSCQ 676
+Q++ + +E K +L + + EE ++ +N + L Q + EV +E +
Sbjct: 1384 IQRT-EELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAA 1442
Query: 677 VLQWQKQHQNDLKMLAAKEEQLREFQEEMAALKENLLEDDKEPCCLPQWSVPKDTCRLYR 736
K+ +N K+LA +++ E E+ A ++ S+ + ++
Sbjct: 1443 CAALDKKQRNFDKILAEWKQKCEETHAELEASQKE------------SRSLSTELFKIKN 1490
Query: 737 GNDQIMTNLEQWAKQQKVANEKLGN---QLREQVKYIAKLSG-EKDREPTRASSPNTTRP 792
++ + LE ++ K +++ + Q+ E K I +L +K E ++
Sbjct: 1491 AYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAALEE 1550
Query: 793 SSPSHSHLHSVMVHLQQENKKLKKEIEEK 821
+ S H ++ +Q E ++K E++ K
Sbjct: 1551 AEASLEHEEGKILRIQLELNQVKSEVDRK 1579
Score = 79.7 bits (195), Expect = 1e-14
Identities = 114/613 (18%), Positives = 273/613 (44%), Gaps = 110/613 (17%)
Query: 10 EKLHLAQEQLALAGDKIASLERSLNLYRDKYQSSLSNIELLECQVKML---QGELGGIMG 66
++L A+E + K ASLE++ +++ + + ++E L Q I+
Sbjct: 1399 QRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNFDKILA 1458
Query: 67 QEPENKGDHSKVRIYTSPCMIQEHQETQKRLSEVWQKVSQQDDLIQELRNKLACSNALVL 126
E + K + + + S +E++ +E+++ + ++ + +L L
Sbjct: 1459 -EWKQKCEETHAELEAS------QKESRSLSTELFKIKNAYEESLDQLE---------TL 1502
Query: 127 EREKALIKLQADFASCTATHRYPPSSSEECEDIKKILKHLQEQKDSQCLHVEEYQNLVKD 186
+RE LQ + + T + +++KI K ++++K +
Sbjct: 1503 KRENK--NLQQEISDLT---EQIAEGGKRIHELEKIKKQVEQEK--------------SE 1543
Query: 187 LRVELEAVSEQKRNIMKDMMKLELDLHGLREETSAHIERKDKDITILQCRLQELQLEFTE 246
L+ LE + +++++L+L+ ++ E I KD++I +++ + E
Sbjct: 1544 LQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEID----QMKRNHIRIVE 1599
Query: 247 TQKLTL-----KKDKFLQEKDEM---LQELEKKLTQVQNSLLKKEKELEKQQCMATELEM 298
+ + TL ++ ++ K +M L E+E +L + + Q + + ++
Sbjct: 1600 SMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQAILKDTQL 1659
Query: 299 TVKEAKQDKSK--------EAECKALQAEVQKLKNSLEEAKQQERLAAQQAAQCKEEAAL 350
+ +A + + E LQAE+++L+ +LE+ ++ ++A Q+ E L
Sbjct: 1660 HLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQL 1719
Query: 351 AGCHLEDTQRKLQKGLLLDKQKADT-IQELQRELQMLQKESSMAEKEQTSNRKRVEELSL 409
H ++T L+ K+K +T I ++Q E++ + +E+ AE++ +K + + ++
Sbjct: 1720 --LHTQNT------SLINTKKKLETDISQIQGEMEDIIQEARNAEEKA---KKAITDAAM 1768
Query: 410 ELSEALRKLENSDKEKRQLQKTVAEQDMKMNDMLDRIKHQHREQGSIKCKLEEDLQEATK 469
++E L+K +++ +++K + EQ +K D+ QHR L EA +
Sbjct: 1769 -MAEELKKEQDTSAHLERMKKNL-EQTVK--DL------QHR------------LDEAEQ 1806
Query: 470 L-LEDKREQLKKSKEHEKLMEGELEALRQE-------FKKKDKTLKENSRKLEEENEN-- 519
L L+ ++Q++K + + +EGE+E+ ++ +K ++ +KE + + EE+ +N
Sbjct: 1807 LALKGGKKQIQKLEARVRELEGEVESEQKRNVEAVKGLRKHERKVKELTYQTEEDRKNIL 1866
Query: 520 --------LRAELQCCSTQLESSLNKYNTSQQVIQDLNKEIALQKESLMSLQAQLDKALQ 571
L+A+++ Q E + + N + + + E+ +E ++Q++K
Sbjct: 1867 RLQDLVDKLQAKVKSYKRQAEEAEEQSNVNLSKFRRIQHELEEAEERADIAESQVNKLRV 1926
Query: 572 KEKHYLQTTITKE 584
K + I++E
Sbjct: 1927 KSREVHTKIISEE 1939
Score = 72.4 bits (176), Expect = 2e-12
Identities = 102/500 (20%), Positives = 221/500 (44%), Gaps = 88/500 (17%)
Query: 5 NENTGEKLHLAQEQLALAGDKIASLERSLNLYRDKYQSSLSNIELLECQVKMLQGELGGI 64
N+N +++ EQ+A G +I LE+ ++ QV+ + EL
Sbjct: 1506 NKNLQQEISDLTEQIAEGGKRIHELEK------------------IKKQVEQEKSELQAA 1547
Query: 65 MGQEPENKGDHSKVRIYTSPCMIQEHQETQKRLSEVWQKVSQQDDLIQELRNKLACSNAL 124
+ +E E +H + +I ++ E + SEV +K++++D+ I +++ ++
Sbjct: 1548 L-EEAEASLEHEEGKI------LRIQLELNQVKSEVDRKIAEKDEEIDQMKR----NHIR 1596
Query: 125 VLEREKALIKLQADFASCTATHRYPPSSSEECEDIKKILKHLQEQKDSQCLHVEEYQNLV 184
++E ++ L A+ S R + +++ L H + Q ++
Sbjct: 1597 IVESMQS--TLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQAIL 1654
Query: 185 KDLRVELEAVSEQKRNIMKDMMKLELDLHGLREETSAHIERKDKDITILQCRLQELQLEF 244
KD ++ L+ D ++ + DL +E A +ER+ +LQ ++EL+
Sbjct: 1655 KDTQLHLD-----------DALRSQEDL----KEQLAMVERR---ANLLQAEIEELRATL 1696
Query: 245 TETQKLTLKKDKFLQEKDEMLQELEKKLTQVQNSLLKKEKELEKQQCMATELEMTVKEAK 304
+T++ ++ L + E +Q L + T + N+ K E ++ + Q E+E ++EA
Sbjct: 1697 EQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQ---GEMEDIIQEA- 1752
Query: 305 QDKSKEAECKALQAEVQKLKNSLEEAKQQERLAAQQAAQCKEEAALAGCHLEDTQRKLQK 364
+N+ E+AK+ AA A + K+E HLE ++ L++
Sbjct: 1753 -------------------RNAEEKAKKAITDAAMMAEELKKEQD-TSAHLERMKKNLEQ 1792
Query: 365 GLLLDKQKADTIQEL-----QRELQMLQKESSMAEKEQTSNRKRVEELSLELSEALRKLE 419
+ + + D ++L ++++Q L+ E E S +KR ++E + LRK E
Sbjct: 1793 TVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKR----NVEAVKGLRKHE 1848
Query: 420 NSDKEKRQLQKTVAEQDMKMNDMLDRIKHQHREQGSIKCKLEEDLQEATKLLEDKR---E 476
KE + + +++ D++D+++ + + S K + EE +++ L R
Sbjct: 1849 RKVKELTYQTEEDRKNILRLQDLVDKLQAKVK---SYKRQAEEAEEQSNVNLSKFRRIQH 1905
Query: 477 QLKKSKEHEKLMEGELEALR 496
+L++++E + E ++ LR
Sbjct: 1906 ELEEAEERADIAESQVNKLR 1925
Score = 70.1 bits (170), Expect = 9e-12
Identities = 98/430 (22%), Positives = 188/430 (43%), Gaps = 30/430 (6%)
Query: 433 AEQDMKMNDMLDRIKHQHREQGSIKCKLEEDLQEATKLLEDKRE-QLKKSKEHEKLMEGE 491
AE + +M +M + + E + K +E ++ L+++K + QL+ E + L + E
Sbjct: 847 AETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADSLADAE 906
Query: 492 LEALRQEFKKK---DKTLKENSRKLEEENENLRAELQCCSTQLESSLNKYNTSQQVIQDL 548
E Q K K + +KE + + E+E E + AEL +LE ++ I DL
Sbjct: 907 -ERCDQLIKTKIQLEAKIKEVTERAEDEEE-INAELTAKKRKLEDECSELKKD---IDDL 961
Query: 549 NKEIALQKESLMSLQAQLDKALQKEKHYLQTTITKEAYDALSRKSAACQ--DDLTQALEK 606
+A ++ + + ++ K L +E L TI K + + + A Q DDL +K
Sbjct: 962 ELTLAKVEKEKHATENKV-KNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDK 1020
Query: 607 LNHVTSETKSLQQSLTQTQEKKAQLEEEIIAYEERMKKLNTELRKLRGFHQESELEVHAF 666
+N +T L+Q + + Q ++ + E +KL +L+ + + E +
Sbjct: 1021 VNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQL 1080
Query: 667 DKKLEEMSCQVLQWQKQHQNDLKMLAAKEEQLREFQEEMAALKENLLEDDKEPCCLPQWS 726
D+KL++ ++ Q + +++ + +++++E Q A ++E LE++ E +
Sbjct: 1081 DEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQ---ARIEE--LEEEIEAERASRAK 1135
Query: 727 VPKDTCRLYRGNDQIMTNLEQWAKQQKVANEKLGNQLREQVKYIAKLSGEKDREPTRASS 786
K L R ++I LE+ E N+ RE + E+ A++
Sbjct: 1136 AEKQRSDLSRELEEISERLEEAGGATSAQIEM--NKKREAEFQKMRRDLEEATLQHEATA 1193
Query: 787 PNTTRPSSPSHSHLHSVMVHLQQENKKLKKEIEEKKMK----AENTRLCTKALGPSRTES 842
+ + S + L + +LQ+ +KL+KE E KM+ A N +KA G
Sbjct: 1194 ATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKG------ 1247
Query: 843 TQREKVCGTL 852
EK+C L
Sbjct: 1248 -NLEKMCRAL 1256
Score = 37.7 bits (86), Expect = 0.047
Identities = 53/241 (21%), Positives = 97/241 (40%), Gaps = 30/241 (12%)
Query: 604 LEKLNHVTSETKSLQQSLTQTQEKKAQLEEEIIAYEERMKKLNTELRKLRGFHQESELEV 663
L K E ++++ +T+E+ A+ E + EE+M L E L +L+V
Sbjct: 843 LLKSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDL-------QLQV 895
Query: 664 HAFDKKL---EEMSCQVLQWQKQHQNDLKMLAAKEEQLREFQEEMAALKENLLEDDKEPC 720
A L EE Q+++ + Q + +K + + E E E+ A K L ++ E
Sbjct: 896 QAEADSLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSE-- 953
Query: 721 CLPQWSVPKDTCRLYRGNDQIMTNLEQWAKQQKVANEKLGNQLREQV---KYIAKLSGEK 777
L + D + L + K++ K+ N E + IAKL+ EK
Sbjct: 954 -------------LKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEK 1000
Query: 778 DR-EPTRASSPNTTRPSSPSHSHLHSVMVHLQQENKKLKKEIE-EKKMKAENTRLCTKAL 835
+ + + + + L + L+Q+ L+ +E EKK++ + R K
Sbjct: 1001 KALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLE 1060
Query: 836 G 836
G
Sbjct: 1061 G 1061
>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
sapiens]
Length = 1939
Score = 121 bits (303), Expect = 3e-27
Identities = 159/783 (20%), Positives = 334/783 (42%), Gaps = 76/783 (9%)
Query: 78 VRIYTSPCMIQEHQETQKRLSEVWQKVSQQDDLIQ--ELRNKLACSNALVLEREKALIKL 135
+++Y + + ET+K ++ + ++ + + + E + K + L +EK ++L
Sbjct: 834 MKLYFKIKPLLKSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQL 893
Query: 136 QADFASCTATHRYPPSSSEECEDIKKILKHLQEQKDSQCLHVEEYQNLVKDLRVELEAVS 195
Q + + E C+ + K L+ + E+ + + +L + +
Sbjct: 894 QVQAEADALA-----DAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLE 948
Query: 196 EQKRNIMKDMMKLELDLHGLREETSAHIERKDKDITILQCRLQELQLEFTETQKLTLKKD 255
++ + KD+ LEL L + +E A E K K++T L E KLT +K
Sbjct: 949 DECSELKKDIDDLELTLAKVEKEKHA-TENKVKNLTEEMAGLDET------IAKLTKEKK 1001
Query: 256 KFLQEKDEMLQELEKKLTQVQNSLLKKEKELEKQQCMATELEMTVKEAKQDKSKEAECKA 315
+ + L +L+ + +V N+L K + +LE+Q +LE ++++ K+ C
Sbjct: 1002 ALQEAHQQTLDDLQMEEDKV-NTLTKAKTKLEQQ---VDDLEGSLEQEKK------LCMD 1051
Query: 316 LQAEVQKLKNSLEEAKQQERLAAQQAAQCKEEAALAGCHLEDTQRKLQKGLLLDKQKADT 375
L+ +KL+ L+ A++ Q E+ + + Q K++ L Q
Sbjct: 1052 LERAKRKLEGDLKLAQESTMDTENDKQQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKK 1111
Query: 376 IQELQRELQMLQKE-------SSMAEKEQTSNRKRVEELSLELSEA----LRKLENSDKE 424
I+ELQ ++ L++E + AEK+++ + +EE+S L EA ++E + K
Sbjct: 1112 IKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKR 1171
Query: 425 KRQLQK--------------TVAEQDMKMNDMLDRIKHQHREQGSIKCKLEEDLQEATKL 470
+ + QK T A K D + + Q +K KLE++ E
Sbjct: 1172 EAEFQKMRRDLEESTLQHEATAAALRKKHADSVAELGEQIDSLQRVKQKLEKEKSELKME 1231
Query: 471 LED---KREQLKKSKEHEKLMEGELEALRQEFKKKDKTLKENSRKLEEENENLRAELQCC 527
+ D E + K+K + + M LE E K K++ + +L + L E
Sbjct: 1232 INDLASNMETVSKAKANFEKMCRTLEDQLSEIKTKEEEQQRLINELSAQKARLHTESGEF 1291
Query: 528 STQL---ESSLNKYNTSQQVIQDLNKEIALQKESLMSLQAQLDKALQKEKHYLQTTITKE 584
S QL ++ +++ + +Q +E+ Q E ++ L ALQ +H + +E
Sbjct: 1292 SRQLDEKDAMVSQLSRGKQAFTQQIEELKRQLEEETKAKSTLAHALQSARH--DCDLLRE 1349
Query: 585 AYDALSRKSAACQDDLTQALEKLN--HVTSETKSLQQSLTQTQEKKAQLEEEIIAYEERM 642
Y+ A Q +++A ++ ET ++Q++ + +E K +L + + EE +
Sbjct: 1350 QYEEEQEAKAELQRGMSKANSEVAQWRTKYETDAIQRT-EELEEAKKKLAQRLQDAEEHV 1408
Query: 643 KKLNTELRKLRGFHQESELEVHAFDKKLEEMSCQVLQWQKQHQNDLKMLAAKEEQLREFQ 702
+ +N++ L Q + EV +E + + K+ +N K+LA +++ E Q
Sbjct: 1409 EAVNSKCASLEKTKQRLQNEVEDLMIDVERSNAACIALDKKQRNFDKVLAEWKQKYEETQ 1468
Query: 703 EEMAALKENLLEDDKEPCCLPQWSVPKDTCRLYRGNDQIMTNLEQWAKQQKVANEKLGN- 761
E+ A ++ S+ + ++ ++ + +LE ++ K +++ +
Sbjct: 1469 AELEASQKE------------SRSLSTELFKVKNAYEESLDHLETLKRENKNLQQEISDL 1516
Query: 762 --QLREQVKYIAKLSG-EKDREPTRASSPNTTRPSSPSHSHLHSVMVHLQQENKKLKKEI 818
Q+ E K+I +L +K + ++ + + S H ++ +Q E ++K EI
Sbjct: 1517 TEQIAEGGKHIHELEKVKKQLDHEKSELQTSLEEAEASLEHEEGKILRIQLELNQVKSEI 1576
Query: 819 EEK 821
+ K
Sbjct: 1577 DRK 1579
Score = 112 bits (280), Expect = 2e-24
Identities = 174/889 (19%), Positives = 389/889 (43%), Gaps = 97/889 (10%)
Query: 12 LHLAQEQLALAGDKIASLERSLNLYRDKYQSSLSNIELLECQVKMLQGELGG--IMGQEP 69
+ L + + L GD + E +++ DK Q + ++ E ++ LQG++ + +
Sbjct: 1050 MDLERAKRKLEGDLKLAQESTMDTENDKQQLN-EKLKKKEFEMSNLQGKIEDEQALAIQL 1108
Query: 70 ENKGDHSKVRIYTSPCMIQEHQ----ETQKRLSEVWQKVSQQDDLIQELRNKLACSNALV 125
+ K + RI I+ + + +K+ S++ +++ + + ++E + +
Sbjct: 1109 QKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMN 1168
Query: 126 LEREKALIKLQADFASCTATHRYPPSS------------SEECEDIKKILKHLQEQKDSQ 173
+RE K++ D T H ++ E+ + ++++ + L+++K
Sbjct: 1169 KKREAEFQKMRRDLEESTLQHEATAAALRKKHADSVAELGEQIDSLQRVKQKLEKEKS-- 1226
Query: 174 CLHVEEYQNLVKDLRVELEAVSEQKRNIMKDMMKLELDLHGLREETSAHIERKDKDITIL 233
E + + DL +E VS+ K N K LE L ++ + +R +++
Sbjct: 1227 -----ELKMEINDLASNMETVSKAKANFEKMCRTLEDQLSEIKTKEEEQ-QRLINELSAQ 1280
Query: 234 QCRLQELQLEFTE--------TQKLTLKKDKFLQEKDEMLQELEKKLTQVQNSL------ 279
+ RL EF+ +L+ K F Q+ +E+ ++LE++ T+ +++L
Sbjct: 1281 KARLHTESGEFSRQLDEKDAMVSQLSRGKQAFTQQIEELKRQLEEE-TKAKSTLAHALQS 1339
Query: 280 ------LKKEKELEKQQCMATELEMTVKEAKQDKSK---EAECKALQAEVQKLKNSLEEA 330
L +E+ E+Q+ A EL+ + +A + ++ + E A+Q + LEEA
Sbjct: 1340 ARHDCDLLREQYEEEQEAKA-ELQRGMSKANSEVAQWRTKYETDAIQRTEE-----LEEA 1393
Query: 331 KQQERLAAQQAAQCKEEAALAGCHLEDTQRKLQ---KGLLLDKQKADT----IQELQREL 383
K++ Q A + E LE T+++LQ + L++D ++++ + + QR
Sbjct: 1394 KKKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLMIDVERSNAACIALDKKQRNF 1453
Query: 384 QMLQKESSMAEKEQTSNRKRVEELSLELSEALRKLENSDKEKRQLQKTVAEQDMKMNDML 443
+ E +E + + ++ S LS L K++N+ +E +T+ ++ + +
Sbjct: 1454 DKVLAEWKQKYEETQAELEASQKESRSLSTELFKVKNAYEESLDHLETLKRENKNLQQEI 1513
Query: 444 DRIKHQHREQGSIKCKLEE---DLQEATKLLEDKREQLKKSKEHE--KLMEGELEALRQE 498
+ Q E G +LE+ L L+ E+ + S EHE K++ +LE L Q
Sbjct: 1514 SDLTEQIAEGGKHIHELEKVKKQLDHEKSELQTSLEEAEASLEHEEGKILRIQLE-LNQV 1572
Query: 499 FKKKDKTLKENSRKLEEENENLRAELQCCSTQLESSLNKYNTSQQVIQDLNKEIALQKES 558
+ D+ + E +L++ N ++ + L++ + N + ++ + + ++ +
Sbjct: 1573 KSEIDRKIAEKDEELDQLKRNHLRVVESMQSTLDAEIRSRNDALRIKKKMEGDLNEMEIQ 1632
Query: 559 LMSLQAQLDKALQKEKHYLQTTITKEAYDALSRKSAACQDDLTQAL----EKLNHVTSET 614
L Q +AL+ ++ I K+ L + QDDL + L + N + +E
Sbjct: 1633 LNHANRQAAEALRNLRN--TQGILKDTQLHLD-DAIRGQDDLKEQLAMVERRANLMQAEV 1689
Query: 615 KSLQQSLTQTQEKKAQLEEEIIAYEERMKKLNTELRKLRGFHQESELEVHAFDKKLEEMS 674
+ L+ SL +T+ + E+E++ ER++ L+T+ L ++ E ++ ++E++
Sbjct: 1690 EELRASLERTERGRKMAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIV 1749
Query: 675 CQVLQWQKQHQNDLKMLAAKEEQLREFQEEMAAL---KENLLEDDKEPCCLPQWSVPKDT 731
+ +++ + + A E+L++ Q+ A L K+N+ + K+ L +
Sbjct: 1750 QEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKD---LQLRLDEAEQ 1806
Query: 732 CRLYRGNDQI------MTNLEQWAKQQKVANEKLGNQLREQVKYIAKLS--GEKDREPTR 783
L G QI + LE + ++ N + LR+ + + +L+ E+DR+
Sbjct: 1807 LALKGGKKQIQKLEARVRELESEVESEQKHNVEAVKGLRKHERRVKELTYQTEEDRKNIL 1866
Query: 784 ASSPNTTRPSSPSHSHLHSVMVHLQQEN------KKLKKEIEEKKMKAE 826
+ + ++ +Q N +KL+ E+EE K +A+
Sbjct: 1867 RLQDLVDKLQTKVKAYKRQAEEAEEQSNVNLAKFRKLQHELEEAKERAD 1915
Score = 82.4 bits (202), Expect = 2e-15
Identities = 124/602 (20%), Positives = 266/602 (44%), Gaps = 88/602 (14%)
Query: 10 EKLHLAQEQLALAGDKIASLERSLNLYRDKYQSSLSNIELLECQVKMLQGELGGIMGQEP 69
++L A+E + K ASLE++ +++ + + ++E L
Sbjct: 1399 QRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLMIDVERSNAACIALD----------- 1447
Query: 70 ENKGDHSKVRIYTSPCMIQEHQETQKRLSEVWQKVSQQDDLIQEL-RNKLACSNAL---- 124
+ + + KV Q+++ETQ L E QK S+ L EL + K A +L
Sbjct: 1448 KKQRNFDKVLAEWK----QKYEETQAEL-EASQKESR--SLSTELFKVKNAYEESLDHLE 1500
Query: 125 VLEREKALIKLQADFASCTATHRYPPSSSEECEDIKKILKHLQEQKDSQCLHVEEYQNLV 184
L+RE LQ + + T E E +KK L H +
Sbjct: 1501 TLKRENK--NLQQEISDLTEQIAEGGKHIHELEKVKKQLDHEK----------------- 1541
Query: 185 KDLRVELEAVSEQKRNIMKDMMKLELDLHGLREETSAHIERKDKDITILQCRLQELQLEF 244
+L+ LE + +++++L+L+ ++ E I KD+++ +L+ L
Sbjct: 1542 SELQTSLEEAEASLEHEEGKILRIQLELNQVKSEIDRKIAEKDEELD----QLKRNHLRV 1597
Query: 245 TETQKLTL-----KKDKFLQEKDEM---LQELEKKLTQVQNSLLKKEKELEKQQCMATEL 296
E+ + TL ++ L+ K +M L E+E +L + + L Q + +
Sbjct: 1598 VESMQSTLDAEIRSRNDALRIKKKMEGDLNEMEIQLNHANRQAAEALRNLRNTQGILKDT 1657
Query: 297 EMTVKEA--KQDKSK------EAECKALQAEVQKLKNSLEEAKQQERLAAQQAAQCKEEA 348
++ + +A QD K E +QAEV++L+ SLE ++ ++A Q+ E
Sbjct: 1658 QLHLDDAIRGQDDLKEQLAMVERRANLMQAEVEELRASLERTERGRKMAEQELLDASERV 1717
Query: 349 ALAGCHLEDTQRKLQKGLLLDKQKADT-IQELQRELQMLQKESSMAEKEQTSNRKRVEEL 407
L H ++T L+ K+K +T I ++Q E++ + +E+ AE++ +K + +
Sbjct: 1718 QL--LHTQNT------SLINTKKKLETDISQIQGEMEDIVQEARNAEEKA---KKAITDA 1766
Query: 408 SLELSEALRKLENS----DKEKRQLQKTVAEQDMKMNDMLD-RIKHQHREQGSIKCKLEE 462
++ ++E L+K +++ ++ K+ +++TV + +++++ +K ++ ++ ++ E
Sbjct: 1767 AM-MAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRE 1825
Query: 463 DLQEATKLLEDKREQLKKSKEHEKLMEGELEALRQEFKKKDKTLKENSRKLEEENENLRA 522
E + E +K ++HE+ ++ EL +E +K N +L++ + L+
Sbjct: 1826 LESEVESEQKHNVEAVKGLRKHERRVK-ELTYQTEEDRK-------NILRLQDLVDKLQT 1877
Query: 523 ELQCCSTQLESSLNKYNTSQQVIQDLNKEIALQKESLMSLQAQLDKALQKEKHYLQTTIT 582
+++ Q E + + N + + L E+ KE ++Q++K K + I+
Sbjct: 1878 KVKAYKRQAEEAEEQSNVNLAKFRKLQHELEEAKERADIAESQVNKLRVKSREVHTKVIS 1937
Query: 583 KE 584
+E
Sbjct: 1938 EE 1939
>gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo sapiens]
Length = 1116
Score = 120 bits (300), Expect = 7e-27
Identities = 156/732 (21%), Positives = 302/732 (41%), Gaps = 87/732 (11%)
Query: 157 EDIKKILKHLQEQKDSQCLHVEEYQNLVKDLRVE-----LEAVSEQKRNIMKDMMKLELD 211
E IKK+L+ LQ + S E+++ + E LE++ EQK K+ L +
Sbjct: 307 ESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKE---KENSMLREE 363
Query: 212 LHGLREET---------SAHIERKDKDITILQCRLQELQLEFTETQKLTLKKDKFLQEKD 262
+H E IE KD I+ ++ L++L+ E Q L +E++
Sbjct: 364 MHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLE---EEIQMLKSNGALSTEERE 420
Query: 263 EMLQELE----------KKLTQVQNSLLKKEKELEKQQCMATELEMTVKEAKQDKS-KEA 311
E ++++E K+ Q++ L KE + E+ + A L+ + + KQ+ S K+
Sbjct: 421 EEMKQMEVYRSHSKFMKNKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQVKQELSRKDT 480
Query: 312 ECKALQAEVQKLKNSLEEAKQQERLAAQQAAQCKEEAALAGCHLEDTQRKLQKGLLLDKQ 371
E ALQ +++ L N ++KQ + + ++ AA+ ++ + +L++ + +
Sbjct: 481 ELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNK 540
Query: 372 KADTIQELQRE-------LQMLQKESSMAEKEQTSNRKRVEELSLELSEALRKLENSDKE 424
K IQ++ E + L+ + E++ +K++E L +L + +++ + +
Sbjct: 541 KTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKER 600
Query: 425 KRQLQKTVAEQDMKMNDMLDRIKHQHREQGSIKCKLEEDLQEATKLLEDKREQLKKSKEH 484
+ LQ D + + + + + R +K + + D +E + +++ ++ LK KE
Sbjct: 601 VKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEK 660
Query: 485 EKLMEGELE--------------ALRQEFKKKDKTLKENSRKLEEENEN-LRAELQCCST 529
L++G+L +L KKD LK LE++ E L+ E Q
Sbjct: 661 VSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKA 720
Query: 530 QLESSLNKYNTSQQV--IQDLNKEIALQKESLMSLQAQLDKALQKEKHYLQTTITKEAYD 587
E++L + + IQ L +EI K+ QA++D+ L+ K K+
Sbjct: 721 H-EAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKI 779
Query: 588 ALSRKSAACQDD-------------------LTQALEKLNHVTSETKSLQQSLTQTQEKK 628
A + Q+ L +A + +++ ++ LQ SL + ++
Sbjct: 780 AELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRI 839
Query: 629 AQLEEEI-----IAYEERMKKLNTELRKLRGFHQESELEVHAFDKKLEEMSCQVLQWQKQ 683
+LEE + I E M E + Q EL + A +K +E+ +
Sbjct: 840 EELEEALRESVQITAEREMVLAQEESARTNAEKQVEEL-LMAMEKVKQELESMKAKLSST 898
Query: 684 HQNDLKMLAAKEEQLREFQEEMAALKENLLEDDKEPCCLPQWSVPKDTCRLYRGNDQIMT 743
Q+ LA KE L + E E +LE +E + L + + T
Sbjct: 899 QQS----LAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKT 954
Query: 744 NLEQWAKQQKVANEKLGNQLREQVKYIAKLSGEKDREPTRASSPNTTRPSSPSHSHLHSV 803
E A +++ ++L QL++Q + KL + + SS + PS +
Sbjct: 955 QEEVAALKRE--KDRLVQQLKQQTQNRMKLMADNYEDDHFKSSHSNQTNHKPSPDQIIQP 1012
Query: 804 MVHLQQENKKLK 815
++ L Q KLK
Sbjct: 1013 LLELDQNRSKLK 1024
Score = 97.8 bits (242), Expect = 4e-20
Identities = 145/698 (20%), Positives = 297/698 (42%), Gaps = 101/698 (14%)
Query: 5 NENTGEKLHLAQEQLALAGDKIASLERSLNLYRDKYQSSLSN--IELLECQVKMLQGELG 62
N K Q + + KI+S+ER L ++ Q SN + E + +M Q E+
Sbjct: 370 NAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVY 429
Query: 63 GIMGQEPENKGDHSKVRIYTSPCMIQEHQET----QKRLSEVWQKVSQQDDLIQELRNKL 118
+ +NK + K + + +E ++ Q + +V Q++S++D + L+ KL
Sbjct: 430 RSHSKFMKNKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKL 489
Query: 119 ACSNALVLEREKALIKLQADFASCTATHRYPPSSSEECEDIKKILKH-------LQEQKD 171
T T+++ S + E +K+ L LQ + D
Sbjct: 490 E-----------------------TLTNQFS-DSKQHIEVLKESLTAKEQRAAILQTEVD 525
Query: 172 SQCLHVEEYQNLVKDLRVELEAVSEQKR------NIMKDMMKL-ELDLHGLR---EETSA 221
+ L +EE + ++ +++ ++E+K + +KDM+ + E ++ L+ E
Sbjct: 526 ALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQE 585
Query: 222 HIERKDKDITILQCRLQELQLEFTETQKLTLKKDKFLQEKDEMLQELEKKLTQVQNSLLK 281
+ K+K ++ L+ R++ LQ + T T ++ L EK+ ++ L+++ + + +
Sbjct: 586 QLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDER---E 642
Query: 282 KEKELEKQQCMATELEMTVKEAKQDKS-KEAECKALQAEVQKLKNSLEEAKQQERLAAQQ 340
K++E++ + +L+ V + D S KEA L+ L +S K+ RL +
Sbjct: 643 KQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASS--GLKKDSRLKTLE 700
Query: 341 AA--QCKEEAALAGCHLEDTQRKLQKGLL---LDKQKADTIQELQRELQMLQKESSMA-- 393
A Q KEE +E +K + L + +D IQ L+RE+ + ESS A
Sbjct: 701 IALEQKKEECL----KMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQA 756
Query: 394 ------------EKEQTSNRKRVEELSLELSEALRKLENSDKEKRQLQKTVAEQDMK--- 438
E E+ K++ EL ++ + +K+ N K K Q++K + Q ++
Sbjct: 757 EVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANL-KHKEQVEKKKSAQMLEEAR 815
Query: 439 -----MNDMLDRIKHQHREQGSIKCKLEEDLQEATKLLEDKREQLKKSKEHEKLMEGELE 493
+ND +++ R++ +LEE L+E+ ++ ++ L + + E ++E
Sbjct: 816 RREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVE 875
Query: 494 ALRQEFKKKDKTLKENSRKLEEENENLRAELQCCSTQLESSLNKYNTSQQVIQDLNKEIA 553
L +K + L+ KL ++L AE + T L + K+ L + +
Sbjct: 876 ELLMAMEKVKQELESMKAKLSSTQQSL-AEKETHLTNLRAERRKH---------LEEVLE 925
Query: 554 LQKESLMSLQAQLDKALQKEKHYLQTTITKEAYDALSRKSAACQDDLTQALEKL------ 607
+++E+L++ ++ D + + T+E AL R+ L Q +
Sbjct: 926 MKQEALLAAISEKDANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQQTQNRMKLMAD 985
Query: 608 NHVTSETKSLQQSLTQTQEKKAQLEEEIIAYEERMKKL 645
N+ KS + T + Q+ + ++ ++ KL
Sbjct: 986 NYEDDHFKSSHSNQTNHKPSPDQIIQPLLELDQNRSKL 1023
Score = 94.4 bits (233), Expect = 4e-19
Identities = 145/688 (21%), Positives = 298/688 (43%), Gaps = 108/688 (15%)
Query: 219 TSAHIERKDKDITILQCRLQELQLEFTETQKLTLKKDKFLQEKDEMLQELEKKLTQVQNS 278
T H R+ +D TI+ +TQ + ++ L KD ++ E KL+ NS
Sbjct: 138 TVPHSLRQARDNTIMDL----------QTQLKEVLRENDLLRKD--VEVKESKLSSSMNS 185
Query: 279 L-------LKKEKELEKQQCMATELEMTVKEAKQDKSKEAEC--KALQAEVQKLKNSLEE 329
+ LKKE+ L K + + Q++++ + +ALQ E+ +++ L +
Sbjct: 186 IKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDEL-RIQRDLNQ 244
Query: 330 AKQQE-------------------RLAAQQAAQCKEEAALAGCHLEDTQRKLQKGLLLDK 370
QQ+ RL A+ Q KE L LE+ + +++
Sbjct: 245 LFQQDSSSRTGEPCVAELTEENFQRLHAEHERQAKELFLLRKT-LEEMELRIETQKQTLN 303
Query: 371 QKADTIQELQRELQMLQKE--SSMAEKEQTSNRKRVEELSLELSEALRKLENSDKEKRQL 428
+ ++I++L L+MLQ + S+ A +E +R+ E + + LE +KE L
Sbjct: 304 ARDESIKKL---LEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSML 360
Query: 429 QKTV------AEQDMKMNDMLDRIKHQHREQGSIKCKLEEDLQEATKLL----------- 471
++ + A K + I+ + + S++ L DL+E ++L
Sbjct: 361 REEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLR-DLEEEIQMLKSNGALSTEER 419
Query: 472 EDKREQLKKSKEHEKLMEGELEALRQEFKKKDKTLKENSRK----------LEEENENLR 521
E++ +Q++ + H K M+ ++E L++E K+ +E +K +++E
Sbjct: 420 EEEMKQMEVYRSHSKFMKNKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQVKQELSRKD 479
Query: 522 AELQCCSTQLESSLNKYNTSQQVIQDLNKEIALQKESLMSLQAQLD--KALQKEKHYLQT 579
EL T+LE+ N+++ S+Q I+ L + + +++ LQ ++D + +EK +
Sbjct: 480 TELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLN 539
Query: 580 TITKEAYDALSRKSAACQD--DLTQALE----KLNHVTSETKSLQQSLTQTQEKKAQLEE 633
TK+ D K + DL L+ K+N + + ++LQ+ L +++ + L+E
Sbjct: 540 KKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKE 599
Query: 634 EIIAYEERMKKLNTELRKLRGFHQESELEVHAFDKKLEEMSCQVLQWQKQHQNDLKMLAA 693
+ + + +T L L E E + ++ + + + ++ DLK L
Sbjct: 600 RVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDL-- 657
Query: 694 KEEQLREFQEEMAALKENLLEDDKEPCCLPQWSVPKDTCRLYRGNDQIMTNLEQWAKQQK 753
+E++ Q +++ + +LL+ + L + KD+ + LE +Q+K
Sbjct: 658 -KEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDS---------RLKTLEIALEQKK 707
Query: 754 VANEKLGNQLRE--QVKYIAKLSGEK-------DREPTRASSPNTTRPSSPSHSHLHSVM 804
K+ +QL++ + A+ S E +RE TR ++ + L ++
Sbjct: 708 EECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESS--KAQAEVDRLLEIL 765
Query: 805 VHLQQE-NKKLKKEIE-EKKMKAENTRL 830
++ E N K KK E E+++K +N ++
Sbjct: 766 KEVENEKNDKDKKIAELERQVKDQNKKV 793
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 120 bits (300), Expect = 7e-27
Identities = 156/719 (21%), Positives = 323/719 (44%), Gaps = 72/719 (10%)
Query: 94 QKRLSEVWQKVSQQDDLIQEL---RNKLACSNA----LVLEREKALIKLQADFASCTATH 146
+ + SE+ K QQ LI +L + +L N V E+E + +L + T
Sbjct: 1257 EDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQL 1316
Query: 147 RYPPSSSEECEDIKKILKHLQEQKDSQCLHVEEYQNLVKDLRVELE-AVSEQKRNIMKDM 205
EE K + H + C + E ++ + EL+ A+S+ + +
Sbjct: 1317 EELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWR 1376
Query: 206 MKLELDLHGLREETSAHIERKDKDITILQCRLQELQLEFTETQK-----LTLKKDKFLQE 260
K E D EE E K K L RLQE + E TET L K + E
Sbjct: 1377 TKYETDAIQRTEELE---EAKKK----LAQRLQEAE-ENTETANSKCASLEKTKQRLQGE 1428
Query: 261 KDEMLQELEKKLTQVQNSLLKKEKELEKQQCMATELEMTVKEAKQD-KSKEAECKALQAE 319
++++++LE+ T +L KK++ +K + E + + E++ + ++ + E ++L E
Sbjct: 1429 VEDLMRDLERSHTACA-TLDKKQRNFDK---VLAEWKQKLDESQAELEAAQKESRSLSTE 1484
Query: 320 VQKLKNSLEEAKQQERLAAQQAAQCKEEAALAGCHLEDTQRKLQKGLLLDKQKADTIQEL 379
+ K++N+ EE Q ++ +EE + + +T + LQ+ ++ +++
Sbjct: 1485 LFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQEA----EKTKKLVEQE 1540
Query: 380 QRELQMLQKESSMAEKEQTSNRKRVE-ELSLELSEALRKLENSDKEKRQLQKTVAEQDMK 438
+ +LQ+ +E + + + S RV+ ELS SE RK+ D+E QL++
Sbjct: 1541 KSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEA 1600
Query: 439 MNDMLDRIKHQHREQGSIKCKLEEDLQEATKLLEDKREQLKKSKEHEKLMEGELEALR-- 496
+ +LD + +K K+E DL E L Q+ ++++H + ++G+L+ +
Sbjct: 1601 LQSVLDAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLH 1660
Query: 497 -QEFKKKDKTLKENSRKLEEENENLRAELQCCSTQLESSLNKYNTSQQVIQDLNKEIAL- 554
+ + ++ LKE +E N L EL+ LE + S+Q + D + + L
Sbjct: 1661 LDDALRSNEDLKEQLAIVERRNGLLLEELEEMKVALEQTERTRRLSEQELLDASDRVQLL 1720
Query: 555 --QKESLMSLQAQLDKALQKEKHYLQTTITKEAYDALSRKSAACQD------DLTQALEK 606
Q SL++ + +L+ + + + ++ +I +E+ +A + A D +L + +
Sbjct: 1721 HSQNTSLINTKKKLEADIAQCQAEVENSI-QESRNAEEKAKKAITDAAMMAEELKKEQDT 1779
Query: 607 LNHVTSETKSLQQSLTQTQEKKAQLEE--------EIIAYEERMKKLNTELRKLRGFHQE 658
H+ K+L+Q++ Q + + E+ +I E R+++L EL + E
Sbjct: 1780 SAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLENRVRELENELDVEQKRGAE 1839
Query: 659 SELEVHAFDKKLEEMSCQVLQWQKQHQNDLKMLAAKEEQLREFQEEMAALKENLLEDDKE 718
+ H +++K++EM+ Q ++ H+N L++ ++ + + Q ++ + K E ++
Sbjct: 1840 ALKGAHKYERKVKEMTYQA---EEDHKNILRL----QDLVDKLQAKVKSYKRQAEEAEE- 1891
Query: 719 PCCLPQWSVPKDTCRLYRGNDQIMTNLEQWAKQQKVANEKLGNQLREQVKYIAKLSGEK 777
Q + CR ++ LE+ A++ +A ++ N+LR + + + E+
Sbjct: 1892 -----QANTQLSRCR------RVQHELEEAAERADIAESQV-NKLRAKSRDVGSQKMEE 1938
Score = 117 bits (294), Expect = 4e-26
Identities = 193/922 (20%), Positives = 372/922 (40%), Gaps = 133/922 (14%)
Query: 6 ENTGEKLHLAQEQLALAGDKIASLERSLNLYRDKYQSSLSNIE--------------LLE 51
E T E+L ++ + +K+ SL + N + + QS N+ LLE
Sbjct: 861 ERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMDAEERCEGLIKSKILLE 920
Query: 52 CQVKMLQGELGGIMGQEPENKGDHSKVRIYTSPC--MIQEHQETQKRLSEVWQKVSQQDD 109
+VK L L +E N +K R C + ++ + + L++V ++ ++
Sbjct: 921 AKVKELTERLEE---EEEMNSELVAKKRNLEDKCSSLKRDIDDLELTLTKVEKEKHATEN 977
Query: 110 LIQELRNKLACSNALVLEREKALIKLQADFASCTATHRYPPSSSEECEDIKKILKHLQEQ 169
++ L ++ E+ + KL + S H+ + ED L + +
Sbjct: 978 KVKNLSEEMTAL-------EENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAK 1030
Query: 170 KDSQCLHVEEYQNLVKDLRVELEAVSEQKRNIMKDMMKLELDLHGLREETSAHIERKDKD 229
+ Q +E K LR +LE + +K + +DL +++ +++K+ +
Sbjct: 1031 LEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFE 1090
Query: 230 ITILQCRLQELQLEFTETQKLTLKKDKFLQEKDEMLQELEKKLTQVQNSLLKKEKELEKQ 289
++ LQ ++ + Q+ + QK K K LQ + ++ELE+++ K EK+
Sbjct: 1091 LSQLQAKIDDEQVHSLQFQK----KIKELQAR---IEELEEEIEAEHTLRAKIEKQRSDL 1143
Query: 290 QCMATELEMTVKEAKQDKSKEAEC-KALQAEVQKLKNSLEEAK-QQERLAAQQAAQCKEE 347
E+ ++EA S + E K +AE QK++ LEEA Q E AA + +
Sbjct: 1144 ARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADS 1203
Query: 348 AALAGCHLEDTQRKLQKGLLLDKQKADT---IQELQRELQMLQKESSMAEKE-------- 396
A G +++ QR QK L+K+K++ I ++ ++ L K S E+
Sbjct: 1204 VAELGEQIDNLQRVKQK---LEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQF 1260
Query: 397 ------------------------QTSNRK---RVEELSLELSEALRKLENSDKEKRQLQ 429
QT N + RVEE +S+ + + ++ +L+
Sbjct: 1261 SEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELK 1320
Query: 430 KTVAEQDMKMNDML----------DRIKHQHREQGSIKCKLEEDLQEA--------TKLL 471
+ + E+ N M D ++ Q+ E+ K +L+ L +A TK
Sbjct: 1321 RQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYE 1380
Query: 472 EDKREQLKKSKEHEKLMEGELEALRQEFKKKDKTLKENSRKLEEENENLRAELQCCSTQL 531
D ++ ++ +E +K + L QE ++ +T LE+ + L+ E++ L
Sbjct: 1381 TDAIQRTEELEEAKKKLAQRL----QEAEENTETANSKCASLEKTKQRLQGEVEDLMRDL 1436
Query: 532 ESSLNKYNTSQQVIQDLNKEIALQKESLMSLQAQLDKALQKEKHYLQTTITK-------- 583
E S T + ++ +K +A K+ L QA+L+ A QKE L T + K
Sbjct: 1437 ERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAA-QKESRSLSTELFKMRNAYEEV 1495
Query: 584 -EAYDALSRKSAACQDDLTQALEKLNH--------------VTSETKSLQQSLTQTQEKK 628
+ + L R++ Q++++ E++ V E LQ +L + +
Sbjct: 1496 VDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSL 1555
Query: 629 AQLEEEIIAYEERMKKLNTELRKLRGFHQESELE-VHAFDKKLEEMSCQVLQWQKQHQND 687
E +I+ + + ++ +EL + + ++ E+E + ++ E VL + + +ND
Sbjct: 1556 EHEESKILRVQLELSQVKSELDR-KVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRND 1614
Query: 688 LKMLAAKEE-QLREFQEEMAALKENLLEDDKEPCCLPQWSVPKDTCRLYRGNDQIMTNLE 746
L K E L E + ++ + E K + Q + L D + + E
Sbjct: 1615 ALRLKKKMEGDLNEMEIQLGHSNRQMAETQKHLRTV-QGQLKDSQLHL----DDALRSNE 1669
Query: 747 QWAKQQKVANEKLGNQLREQVKYIAKLSGEKDREPTRASSPNTTRPSSPSHSHLHSVMVH 806
+Q + + G L E + L + E TR S +S LHS
Sbjct: 1670 DLKEQLAIVERRNGLLLEELEEMKVAL---EQTERTRRLSEQELLDASDRVQLLHSQNTS 1726
Query: 807 LQQENKKLKKEIEEKKMKAENT 828
L KKL+ +I + + + EN+
Sbjct: 1727 LINTKKKLEADIAQCQAEVENS 1748
Score = 89.4 bits (220), Expect = 1e-17
Identities = 128/651 (19%), Positives = 271/651 (41%), Gaps = 79/651 (12%)
Query: 267 ELEKKLTQVQNSLLKKEKELEKQQCMATELEMTVKEAKQDKSKEAECKALQAEVQKLKNS 326
E EK++ ++ + ++EL + + ELE + Q+K+ LQ +VQ +
Sbjct: 848 EAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKND------LQLQVQSETEN 901
Query: 327 LEEAKQQERLAAQQAAQCKEEAALAGCHLEDTQRKLQKGLLLDKQKADTIQELQRELQML 386
L +A+++ + + + LE+ + + + + D L+R++ L
Sbjct: 902 LMDAEERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDL 961
Query: 387 QKESSMAEKEQTSNRKRVEELSLELSEALRKLENSDKEKRQLQKT-------VAEQDMKM 439
+ + EKE+ + +V+ LS E++ + KEK+ LQ+ + ++ K+
Sbjct: 962 ELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKV 1021
Query: 440 NDMLD---RIKHQHRE-QGSI--KCKLEEDLQEATKLLEDKREQLKKSKEHEKLMEGELE 493
N ++ +++ Q + +GS+ + KL DL+ A + LE LK S+E +E + +
Sbjct: 1022 NGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEG---DLKMSQESIMDLENDKQ 1078
Query: 494 ALRQEFKKKDKTLKENSRKLEEEN------ENLRAELQCCSTQLESSLNKYNTSQQVIQD 547
+ ++ KKK+ L + K+++E + ELQ +LE + +T + I+
Sbjct: 1079 QIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEK 1138
Query: 548 LNKEIALQKESL----------MSLQAQLDKALQKE-----KHYLQTTITKEAYDALSRK 592
++A + E + S Q +++K + E + + T+ EA A RK
Sbjct: 1139 QRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRK 1198
Query: 593 SAACQ--------DDLTQALEKLNHVTSETK----SLQQSLTQTQEKKAQLE-------- 632
A D+L + +KL SE K + ++ + K+ +E
Sbjct: 1199 KQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVED 1258
Query: 633 --EEIIAYEERM-----------KKLNTELRKLRGFHQESELEVHAFDKKLEEMSCQVLQ 679
EI A +E+ +L T+ +L +E E + K + ++ Q+ +
Sbjct: 1259 QFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEE 1318
Query: 680 WQKQHQNDLKMLAAKEEQLREFQEEMAALKENLLEDDKEPCCLPQWSVPKDTCRLYRGND 739
++Q + + K A L+ + + L+E E+++E Q ++ K + +
Sbjct: 1319 LKRQMEEETKAKNAMAHALQSSRHDCDLLREQ-YEEEQEAKAELQRALSKANSEVAQWRT 1377
Query: 740 QIMTNLEQWAKQQKVANEKLGNQLREQVKYIAKLSGE-KDREPTRASSPNTTRPSSPSHS 798
+ T+ Q ++ + A +KL +L+E + + + E T+
Sbjct: 1378 KYETDAIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLE 1437
Query: 799 HLHSVMVHLQQENKKLKKEIEEKKMKAENTRL-CTKALGPSRTESTQREKV 848
H+ L ++ + K + E K K + ++ A SR+ ST+ K+
Sbjct: 1438 RSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKM 1488
Score = 84.3 bits (207), Expect = 4e-16
Identities = 107/470 (22%), Positives = 200/470 (42%), Gaps = 64/470 (13%)
Query: 389 ESSMAEKEQTSNRKRVEELSLEL--SEALRKLENSDKEKRQLQKTVAEQDMKMNDMLDRI 446
+S+ AEKE + ++ E EL SEA RK E +K LQ+ Q ++ + +
Sbjct: 845 KSAEAEKEMATMKEDFERTKEELARSEARRK-ELEEKMVSLLQEKNDLQLQVQSETENLM 903
Query: 447 KHQHREQGSIKCKLEEDLQEATKLLEDKREQLKKSKEHEKLMEGELEALRQEFKKKDKTL 506
+ R +G IK K+ LLE K ++L + E E+ M EL A ++ + K +L
Sbjct: 904 DAEERCEGLIKSKI---------LLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSL 954
Query: 507 KENSRKLEEENENLRAELQCCSTQLESSLNKYNTSQQVIQDLNKEIALQKESLMSLQAQL 566
K + LE + E ++++ + ++ I L KE K+SL Q
Sbjct: 955 KRDIDDLELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKE----KKSLQEAHQQT 1010
Query: 567 DKALQKEKHYLQTTITKEAYDALSRKSAACQDDLTQALEKLNHVTSET----KSLQQSLT 622
LQ E+ + I ++ K DDL +LE+ + ++ + L+ L
Sbjct: 1011 LDDLQVEEDKVNGLIK------INAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLK 1064
Query: 623 QTQEKKAQLEEEIIAYEERMKKLNTELRKLRGFHQESELEVHAFDKKLEEMSCQVLQWQK 682
+QE LE + EE++KK EL +L+ + ++ F KK++E+ ++ + ++
Sbjct: 1065 MSQESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEE 1124
Query: 683 QHQNDLKMLAAKEEQLREFQEEMAALKENLLEDDKEPCCLPQWSVPKDTCRLYRGNDQIM 742
+ + + + A E+Q + E+ + E L E QI
Sbjct: 1125 EIEAEHTLRAKIEKQRSDLARELEEISERLEEASGATSA------------------QIE 1166
Query: 743 TNLEQWAKQQKVANEKLGNQLREQVKYIAKLSGEKDREPTRASSPNTTRPSSPSHSHLHS 802
N ++ A+ QK+ + L+ + A++ + + S + L
Sbjct: 1167 MNKKREAEFQKMRRDLEEATLQHE-----------------ATAATLRKKQADSVAELGE 1209
Query: 803 VMVHLQQENKKLKKEIEEKKMKAENTRLCTKALGPSRTESTQREKVCGTL 852
+ +LQ+ +KL+KE E KM+ ++ +AL S++ E+ C T+
Sbjct: 1210 QIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNI---ERTCRTV 1256
>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
sapiens]
Length = 1940
Score = 119 bits (299), Expect = 9e-27
Identities = 165/805 (20%), Positives = 335/805 (41%), Gaps = 93/805 (11%)
Query: 88 QEHQETQKRLSEVWQKVSQQDDLIQELRNKLACSNALVLEREKALIKLQADFASCTATHR 147
+E T+ ++ + +++S D+ I +L + AL ++AL LQA+ + ++
Sbjct: 967 KEKHATENKVKNLTEELSGLDETIAKLTRE---KKALQEAHQQALDDLQAEEDKVNSLNK 1023
Query: 148 YPPSSSEECEDIKKILKHLQEQKDSQCLHVEEYQNLVKDLRVELEAVSEQKRNIMKDMMK 207
++ ED++ L+ QE+K LRV+LE + +K +
Sbjct: 1024 TKSKLEQQVEDLESSLE--QEKK----------------LRVDLERNKRKLEGDLKLAQE 1065
Query: 208 LELDLHGLREETSAHIERKDKDITILQCRLQELQLEFTETQKLTLKKDKFLQEKDEMLQE 267
LDL +++ +++KD + LQ +++ + Q L L+ K ++E ++E
Sbjct: 1066 SILDLENDKQQLDERLKKKDFEYCQLQSKVE-------DEQTLGLQFQKKIKELQARIEE 1118
Query: 268 LEKKLTQVQNSLLKKEKELEKQQCMATELEMTVKEAKQDKSKEAEC-KALQAEVQKLKNS 326
LE+++ + + K EK+ EL ++EA S + E K +AE KL+
Sbjct: 1119 LEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRD 1178
Query: 327 LEEAK-QQERLAAQQAAQCKEEAALAGCHLEDTQRKLQKGLLLDKQKAD---TIQELQRE 382
LEEA Q E + A + + A G +++ QR QK L+K+K++ I +L
Sbjct: 1179 LEEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQK---LEKEKSEFKLEIDDLSSS 1235
Query: 383 LQMLQKESSMAEK-------EQTSNRKRVEELSLELSEALRKLENSDKEKRQLQKTVAEQ 435
++ + K + EK + + R + EE+ LSE + E +L + + E+
Sbjct: 1236 MESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEK 1295
Query: 436 DMKMNDM----------LDRIKHQHREQGSIKCKLEEDLQEATKLLEDKREQLKKSKEHE 485
+ ++ + + +K Q E+ K L LQ + + REQ ++ +E +
Sbjct: 1296 ESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGK 1355
Query: 486 KLMEGELEALRQEF----KKKDKTLKENSRKLEEENENLRAELQCCSTQLESSLNKYNTS 541
++ L E K + + + +LEE + L LQ Q+E+ K +
Sbjct: 1356 AELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASL 1415
Query: 542 QQVIQDLNKEI---ALQKESLMSLQAQLDKALQKEKHYLQTTITK-----EAYDALSRKS 593
++ Q L E+ + E SL A LDK + L TK +A ++S
Sbjct: 1416 EKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKES 1475
Query: 594 AACQDDL-------TQALEKLNHVTSETKSLQQSLTQTQEKKAQLEEEIIAYEERMKKLN 646
+ +L +AL++L V E K+L+Q + E+ A+ + I E+ K++
Sbjct: 1476 RSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIE 1535
Query: 647 TELRKLRGFHQESELEVHAFDKKLEEMSCQVLQWQKQHQNDLKMLAAKEEQLREFQEEMA 706
E ++ +E+E + + K+ + ++ Q + + + +A K+E++ + +
Sbjct: 1536 LEKADIQLALEEAEAALEHEEAKILRIQLELTQVKSEID---RKIAEKDEEIEQLKRNYQ 1592
Query: 707 ALKENLLEDDKEPCCLPQWSVPKDTCRLYRGNDQIMTNLEQWAKQQKVANEKLGNQLREQ 766
E + + + + RL + + + +E + Q E
Sbjct: 1593 RTVETM-----QSALDAEVRSRNEAIRLKKKMEGDLNEIE-------IQLSHANRQAAET 1640
Query: 767 VKYIAKLSGEKDREPTRASSPNTTRPSSPSHSHLHSVMVHLQQENKKLKKEIEEKKMKAE 826
+K++ + G+ + T+ + R L + +++ L+ E+EE + E
Sbjct: 1641 LKHLRSVQGQ--LKDTQLHLDDALR----GQEDLKEQLAIVERRANLLQAEVEELRATLE 1694
Query: 827 NTRLCTKALGPSRTESTQREKVCGT 851
T K +S +R ++ T
Sbjct: 1695 QTERARKLAEQELLDSNERVQLLHT 1719
Score = 115 bits (288), Expect = 2e-25
Identities = 159/761 (20%), Positives = 325/761 (42%), Gaps = 95/761 (12%)
Query: 127 EREKALIKLQADFASCTATHRYPPSSSEECEDIKKILKHLQEQKDSQCLHVEEYQNLVK- 185
E EK + ++ +F + +E E+ K++ +QE+ D Q E +NL+
Sbjct: 845 ETEKEMATMKEEFQKTKDELAKSEAKRKELEE--KLVTLVQEKNDLQLQVQAESENLLDA 902
Query: 186 --------DLRVELEAVSEQKRNIMKDMMKLELDLHGLREETSAHIERKDKDITILQCRL 237
+ +LEA ++ +D ++ +L + + KDI L+ L
Sbjct: 903 EERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTL 962
Query: 238 QELQLEFTETQ------------------KLTLKKDKFLQEKDEMLQELEKKLTQVQNSL 279
+++ E T+ KLT +K + + L +L+ + +V NSL
Sbjct: 963 AKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKV-NSL 1021
Query: 280 LKKEKELEKQ-----QCMATELEMTVKEAKQDKSKEAECKALQAEVQKLKNSLEEAKQQE 334
K + +LE+Q + E ++ V + + E + K Q + L+N ++ + E
Sbjct: 1022 NKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLEN--DKQQLDE 1079
Query: 335 RLAAQQAAQCKEEAALAGCHLEDTQR---KLQKGLLLDKQKADTIQELQRELQMLQKESS 391
RL + C+ ++ +ED Q + QK + K+ I+EL+ E++ + +
Sbjct: 1080 RLKKKDFEYCQLQS-----KVEDEQTLGLQFQKKI---KELQARIEELEEEIEAERATRA 1131
Query: 392 MAEKEQTSNRKRVEELSLELSEA-------LRKLENSDKEKRQLQKTVAEQDMKMNDMLD 444
EK+++ + +EELS L EA + + + E +L++ + E ++ M+
Sbjct: 1132 KTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVA 1191
Query: 445 RIKHQHREQGS-----------IKCKLEEDLQEATKLLED---KREQLKKSKEHEKLMEG 490
++ +H + + +K KLE++ E ++D E + KSK + + +
Sbjct: 1192 ALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICR 1251
Query: 491 ELEALRQEFKKKDKTLKENSRKLEEENENLRAELQCCSTQL---ESSLNKYNTSQQVIQD 547
LE E + K++ ++ + +L + L+ E S QL ES +++ + S+Q
Sbjct: 1252 TLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQ 1311
Query: 548 LNKEIALQKESLMSLQAQLDKALQKEKHYLQTTITKEAYDALSRKSAACQDDLTQALEKL 607
+E+ Q E + L ALQ +H + +E Y+ A Q L++A ++
Sbjct: 1312 QTEELKRQLEEENKAKNALAHALQSSRH--DCDLLREQYEEEQEGKAELQRALSKANSEV 1369
Query: 608 N--HVTSETKSLQQSLTQTQEKKAQLEEEIIAYEERMKKLNTELRKLRGFHQESELEVHA 665
ET ++Q++ + +E K +L + + EE+++ +N + L Q + EV
Sbjct: 1370 AQWRTKYETDAIQRT-EELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVED 1428
Query: 666 FDKKLEEMSCQVLQWQKQHQNDLKMLAAKEEQLREFQEEM-AALKENLLEDDKEPCCLPQ 724
+E + K+ +N K+LA + + E Q E+ A+LKE+
Sbjct: 1429 LMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESR------------ 1476
Query: 725 WSVPKDTCRLYRGNDQIMTNLEQWAKQQKVANEKLGN---QLREQVKYIAKL-SGEKDRE 780
S+ + +L ++ + LE ++ K +++ + Q+ E K I +L K E
Sbjct: 1477 -SLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIE 1535
Query: 781 PTRASSPNTTRPSSPSHSHLHSVMVHLQQENKKLKKEIEEK 821
+A + + H + ++ +Q E ++K EI+ K
Sbjct: 1536 LEKADIQLALEEAEAALEHEEAKILRIQLELTQVKSEIDRK 1576
Score = 113 bits (282), Expect = 9e-25
Identities = 164/806 (20%), Positives = 336/806 (41%), Gaps = 83/806 (10%)
Query: 24 DKIASLERSLNLYRDKYQSSLSNIELLECQVKMLQGELGGIMGQEPENKGDHSKVRIYTS 83
D +A L + D Q +E + + K+ +L M ++K + K+
Sbjct: 1199 DSVAELGEQI----DNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLE 1254
Query: 84 PCMIQ---EHQETQKRLSEVWQKVSQQDDLIQELRNKLACSNALVLEREKALIKLQADFA 140
+ + +++E Q+ LSE+ + S+ EL +L E+E + +L
Sbjct: 1255 DQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLE-------EKESIVSQLSRSKQ 1307
Query: 141 SCTATHRYPPSSSEECEDIKKILKHLQEQKDSQCLHVEEYQNLVKDLRVELE-AVSEQKR 199
+ T EE K L H + C + E ++ + EL+ A+S+
Sbjct: 1308 AFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANS 1367
Query: 200 NIMKDMMKLELDLHGLREETSAHIERKDKDITILQCRLQELQLEFTETQKLTLKKDKFLQ 259
+ + K E D EE E K K LQ ++++ + L K +
Sbjct: 1368 EVAQWRTKYETDAIQRTEELE---EAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQG 1424
Query: 260 EKDEMLQELEKKLTQVQNSLLKKEKELEKQQCMATELEMTVKEAKQD-KSKEAECKALQA 318
E ++++ ++E+ + +L KK++ +K + E + +E++ + ++ E ++L
Sbjct: 1425 EVEDLMVDVERA-NSLAAALDKKQRNFDK---VLAEWKTKCEESQAELEASLKESRSLST 1480
Query: 319 EVQKLKNSLEEA-------KQQERLAAQQAAQCKEEAALAGCHLEDTQRKLQKGLLLDKQ 371
E+ KLKN+ EEA K++ + Q+ A E+ A G + + ++ ++ ++ +
Sbjct: 1481 ELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQ---IELE 1537
Query: 372 KADTIQELQRELQMLQKESSMAEKEQTSNRKRVE-ELSLELSEALRKLENSDKEKRQLQK 430
KAD +Q+ +E+ A + + + R++ EL+ SE RK+ D+E QL++
Sbjct: 1538 KAD--------IQLALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKR 1589
Query: 431 TVAEQDMKMNDMLDRIKHQHREQGSIKCKLEEDLQEATKLLEDKREQLKKSKEHEKLMEG 490
M LD E +K K+E DL E L Q ++ +H + ++G
Sbjct: 1590 NYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQG 1649
Query: 491 ELEALR---QEFKKKDKTLKENSRKLEEENENLRAELQCCSTQLESSLNKYNTSQQVIQD 547
+L+ + + + + LKE +E L+AE++ LE + ++Q + D
Sbjct: 1650 QLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLD 1709
Query: 548 LNKEIAL---QKESLMSLQAQLDKALQKEKHYLQTTITKEAYDALSRKSAACQDDLTQAL 604
N+ + L Q SL+ + +L+ L + + E DA SR + ++ +A+
Sbjct: 1710 SNERVQLLHTQNTSLIHTKKKLETDLMQ--------LQSEVEDA-SRDARNAEEKAKKAI 1760
Query: 605 EKLNHVTSETKSLQQSLTQTQEKKAQLEEEIIAYEERMKKLNTELRKLRGFHQESELEVH 664
+ E K Q + + K LE+ + + R+ + E L+G + ++
Sbjct: 1761 TDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDE--AEQLALKG----GKKQIQ 1814
Query: 665 AFDKKLEEMSCQVLQWQKQHQNDLKMLAAKEEQLREFQEEMAALKENLLEDDKEPCCLPQ 724
+ ++ E+ ++ QK++ +K L E +++E + E+D+
Sbjct: 1815 KLETRIRELEFELEGEQKKNTESVKGLRKYERRVKELTYQS--------EEDR------- 1859
Query: 725 WSVPKDTCRLYRGNDQIMTNLEQWAKQQKVANEKLGNQLREQVKYIAKLSGEKDREPTRA 784
K+ RL D++ ++ + +Q + A+E+ L + K +L ++R
Sbjct: 1860 ----KNVLRLQDLVDKLQVKVKSYKRQAEEADEQANAHLTKFRKAQHELEEAEERADIAE 1915
Query: 785 SSPNTTRPSSPSHSHLHSVMVHLQQE 810
S N R + + V VH +E
Sbjct: 1916 SQVNKLRAKTRDFTSSRMV-VHESEE 1940
Score = 100 bits (248), Expect = 8e-21
Identities = 139/652 (21%), Positives = 279/652 (42%), Gaps = 81/652 (12%)
Query: 267 ELEKKLTQVQNSLLKKEKELEKQQCMATELE---MTVKEAKQDKSKEAECKALQAEVQKL 323
E EK++ ++ K + EL K + ELE +T+ + K D + +QAE + L
Sbjct: 845 ETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQ-----VQAESENL 899
Query: 324 KNSLEEAKQQERLAAQQAAQCKEEAALAGCHLEDTQRKLQKGLLLDKQKA-DTIQELQRE 382
++ E Q + Q A+ KE A + + ++ L K+K D EL+++
Sbjct: 900 LDAEERCDQLIKAKFQLEAKIKEVTERA-----EDEEEINAELTAKKRKLEDECSELKKD 954
Query: 383 LQMLQKESSMAEKEQTSNRKRVEELSLELS---------------------EALRKLENS 421
+ L+ + EKE+ + +V+ L+ ELS +AL L+
Sbjct: 955 IDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAE 1014
Query: 422 DKEKRQLQKTVAEQDMKMNDMLDRIKHQHREQGSI---KCKLEEDL---QEATKLLEDKR 475
+ + L KT ++ + ++ D+ ++ + + + + K KLE DL QE+ LE+ +
Sbjct: 1015 EDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDK 1074
Query: 476 EQL-----KKSKEHEKLME--GELEALRQEFKKKDKTLKENSRKLEEENENLRA------ 522
+QL KK E+ +L + + L +F+KK K L+ +LEEE E RA
Sbjct: 1075 QQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTE 1134
Query: 523 --------ELQCCSTQLESSLNKYNTSQQVIQDLNKEIALQKESL--MSLQAQLDKALQK 572
EL+ S +LE + +T ++ + E + L +LQ + A +
Sbjct: 1135 KQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVAALR 1194
Query: 573 EKHYLQTTITKEAYDALSRKSAACQ----------DDLTQALEKLN----HVTSETKSLQ 618
+KH E D L R + DDL+ ++E ++ ++ ++L+
Sbjct: 1195 KKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLE 1254
Query: 619 QSLTQTQEKKAQLEEEIIAYEERMKKLNTELRKLRGFHQESELEVHAFDKKLEEMSCQVL 678
L++ + K +++ + + +L TE +L +E E V + + + Q
Sbjct: 1255 DQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTE 1314
Query: 679 QWQKQHQNDLKMLAAKEEQLREFQEEMAALKENLLEDDKEPCCLPQWSVPKDTCRLYRGN 738
+ ++Q + + K A L+ + + L+E E+++E Q ++ K + +
Sbjct: 1315 ELKRQLEEENKAKNALAHALQSSRHDCDLLREQ-YEEEQEGKAELQRALSKANSEVAQWR 1373
Query: 739 DQIMTNLEQWAKQQKVANEKLGNQLREQVKYIAKLSGE-KDREPTRASSPNTTRPSSPSH 797
+ T+ Q ++ + A +KL +L++ + + ++ + E T+
Sbjct: 1374 TKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDV 1433
Query: 798 SHLHSVMVHLQQENKKLKKEIEEKKMKAENTRLCTKA-LGPSRTESTQREKV 848
+S+ L ++ + K + E K K E ++ +A L SR+ ST+ K+
Sbjct: 1434 ERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKL 1485
Score = 75.9 bits (185), Expect = 2e-13
Identities = 107/581 (18%), Positives = 258/581 (44%), Gaps = 77/581 (13%)
Query: 10 EKLHLAQEQLALAGDKIASLERSLNLYRDKYQSSLSNIE---LLECQVKMLQGELGGIMG 66
++L ++EQ+ K ASLE++ + + + + ++E L + Q ++
Sbjct: 1396 QRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLA 1455
Query: 67 QEPENKGDHSKVRIYTSPCMIQEHQETQKRLSEVWQKVSQQDDLIQELRNKLACSNALVL 126
E + K + S+ + S +E++ +E+++ + ++ + +L V
Sbjct: 1456 -EWKTKCEESQAELEAS------LKESRSLSTELFKLKNAYEEALDQLET--------VK 1500
Query: 127 EREKALIKLQADFASCTATHRYPPSSSEECEDIKKILKHLQEQKDSQCLHVEEYQNLVKD 186
K L + AD A + + +++K K ++ +K D
Sbjct: 1501 RENKNLEQEIADLTEQIA------ENGKTIHELEKSRKQIELEK--------------AD 1540
Query: 187 LRVELEAVSEQKRNIMKDMMKLELDLHGLREETSAHIERKDKDITILQCRLQELQLEFTE 246
+++ LE + +++++L+L ++ E I KD++I L+ Q E
Sbjct: 1541 IQLALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRT----VE 1596
Query: 247 TQKLTL-----KKDKFLQEKDEM---LQELEKKLTQVQNSLLKKEKELEKQQCMATELEM 298
T + L +++ ++ K +M L E+E +L+ + K L Q + ++
Sbjct: 1597 TMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQL 1656
Query: 299 TVKEAKQDKSK--------EAECKALQAEVQKLKNSLEEAKQQERLAAQQAAQCKEEAAL 350
+ +A + + E LQAEV++L+ +LE+ ++ +LA Q+ E L
Sbjct: 1657 HLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQL 1716
Query: 351 AGCHLEDTQRKLQKGLLLDKQKADT-IQELQRELQMLQKESSMAEKEQTSNRKRVEELSL 409
H ++T L+ K+K +T + +LQ E++ +++ AE++ +K + + ++
Sbjct: 1717 --LHTQNT------SLIHTKKKLETDLMQLQSEVEDASRDARNAEEKA---KKAITDAAM 1765
Query: 410 ELSEALRKLENSDKEKRQLQKTVAEQDMKMNDMLDRIKHQHREQGSIKC-KLEEDLQEAT 468
++E L+K +++ +++K + + + LD + + G + KLE ++E
Sbjct: 1766 -MAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELE 1824
Query: 469 KLLEDKR----EQLKKSKEHEKLMEGELEALRQEFKKKDKTLKENSRKLEEENENLRAEL 524
LE ++ E +K +++E+ ++ EL +E +K L++ KL+ + ++ + +
Sbjct: 1825 FELEGEQKKNTESVKGLRKYERRVK-ELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQA 1883
Query: 525 QCCSTQLESSLNKYNTSQQVIQDLNKEIALQKESLMSLQAQ 565
+ Q + L K+ +Q +++ + + + + L+A+
Sbjct: 1884 EEADEQANAHLTKFRKAQHELEEAEERADIAESQVNKLRAK 1924
Score = 73.2 bits (178), Expect = 1e-12
Identities = 101/476 (21%), Positives = 204/476 (42%), Gaps = 76/476 (15%)
Query: 389 ESSMAEKEQTSNRKRVEELSLEL--SEALRK-----LENSDKEKRQLQKTVAEQDMKMND 441
+S+ EKE + ++ ++ EL SEA RK L +EK LQ V + + D
Sbjct: 842 KSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLD 901
Query: 442 MLDRIKHQHREQGSIKCKLEEDLQEATKLLEDKREQLKKSKEHEKLMEGELEALRQEFKK 501
+R + K +LE ++E T+ ED+ E + ++ +E E L+++
Sbjct: 902 AEERCDQLIKA----KFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDD 957
Query: 502 KDKTL---KENSRKLEEENENLRAELQCCSTQLESSLNKYNTSQQVIQDLNKEIALQKES 558
+ TL ++ E + +NL EL + L+ ++ K ++ +Q+ +++ +
Sbjct: 958 LELTLAKVEKEKHATENKVKNLTEEL----SGLDETIAKLTREKKALQEAHQQ------A 1007
Query: 559 LMSLQAQLDK--ALQKEKHYLQTTITKEAYDALSRKSAACQDDLTQALEKLNHVTSETKS 616
L LQA+ DK +L K K L+ + E ++ + + DL + KL + K
Sbjct: 1008 LDDLQAEEDKVNSLNKTKSKLEQQV--EDLESSLEQEKKLRVDLERNKRKLE---GDLKL 1062
Query: 617 LQQSLTQTQEKKAQLEEEIIAYEERMKKLNTELRKLRGFHQESELEVHAFDKKLEEMSCQ 676
Q+S+ + K QL+E R+KK + E +L+ ++ + F KK++E+ +
Sbjct: 1063 AQESILDLENDKQQLDE-------RLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQAR 1115
Query: 677 VLQWQKQHQNDLKMLAAKEEQLREFQEEMAALKENLLEDDKEPCCLPQWSVPKDTCRLYR 736
+ + +++ + + A E+Q ++ E+ L E L E V L +
Sbjct: 1116 IEELEEEIEAERATRAKTEKQRSDYARELEELSERLEE---------AGGVTSTQIELNK 1166
Query: 737 GNDQIMTNLEQWAKQQKVANEKLGNQLREQVKYIAKLSGEKDREPTRASSPNTTRPSSPS 796
+ L + ++ + +E + LR++ + S
Sbjct: 1167 KREAEFLKLRRDLEEATLQHEAMVAALRKK--------------------------HADS 1200
Query: 797 HSHLHSVMVHLQQENKKLKKEIEEKKMKAENTRLCTKALGPSRTESTQREKVCGTL 852
+ L + +LQ+ +KL+KE E K++ ++ +++ S+ EK+C TL
Sbjct: 1201 VAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSK---ANLEKICRTL 1253
>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 119 bits (299), Expect = 9e-27
Identities = 198/893 (22%), Positives = 387/893 (43%), Gaps = 132/893 (14%)
Query: 12 LHLAQEQLALAGDKIASLERSLNLYRDKYQSSLSNIE-------LLECQVKMLQGELGGI 64
L LAQE + ++ L+ L + + S IE L+ ++K LQ + +
Sbjct: 1065 LKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEEL 1124
Query: 65 MGQEPENKGDHSKVRIYTSPCMIQEHQETQKRLSEVWQKVSQQDDLIQELRNKLACSNAL 124
+ + +K S + +E +E +RL E S Q ++ NK +
Sbjct: 1125 EEEIEAERASRAKAEKQRSD-LSRELEEISERLEEAGGATSAQIEM-----NKKREAEFQ 1178
Query: 125 VLEREKALIKLQADFASCTATHRYPPSSSE---ECEDIKKILKHLQEQKDSQCLHVEEYQ 181
+ R+ LQ + + T ++ S +E + ++++++ + L+++K + ++
Sbjct: 1179 KMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEID--- 1235
Query: 182 NLVKDLRVELEAVSEQKRNIMKDMMKLELDLHGLREETSAHIERKDKDITILQCRLQELQ 241
DL +E VS+ K N+ K LE L L+ + +R D+T + RLQ
Sbjct: 1236 ----DLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQ-QRLINDLTAQRGRLQTES 1290
Query: 242 LEFTE--------TQKLTLKKDKFLQEKDEMLQELEKKLTQVQNSL------------LK 281
EF+ +L+ K F Q+ +E+ ++LE+++ + +N+L L
Sbjct: 1291 GEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEI-KAKNALAHALQSSRHDCDLL 1349
Query: 282 KEKELEKQQCMATELEMTVKEAKQDKSK---EAECKALQAEVQKLKNSLEEAKQQ--ERL 336
+E+ E+Q+ A EL+ + +A + ++ + E A+Q + LEEAK++ +RL
Sbjct: 1350 REQYEEEQESKA-ELQRALSKANTEVAQWRTKYETDAIQRTEE-----LEEAKKKLAQRL 1403
Query: 337 AAQQAAQCKEEAALAGC-HLEDTQRKLQ---KGLLLDKQKADTI---------------- 376
QAA+ EA A C LE T+++LQ + L+LD ++ +
Sbjct: 1404 ---QAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILA 1460
Query: 377 ------QELQRELQMLQKESSMAEKEQTSNRKRVEELSLELSEALRKLENSDKEKRQLQK 430
+E EL+ QKE+ E + EE +L R+ +N +E L +
Sbjct: 1461 EWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTE 1520
Query: 431 TVAEQDMKMNDMLDRIKHQHREQGSIKCKLEEDLQEATKLLEDKREQLKKSKEHEKLMEG 490
+AE ++++ L++IK Q ++ KC+L+ L+EA LE E K++
Sbjct: 1521 QIAEGGKRIHE-LEKIKKQVEQE---KCELQAALEEAEASLEH---------EEGKILRI 1567
Query: 491 ELEALRQEFKKKDKTLKENSRKLEEENENLRAELQCCSTQLESSLNKYNTS----QQVIQ 546
+LE L Q + D+ + E ++++ N ++ + L++ + N + +++
Sbjct: 1568 QLE-LNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEG 1626
Query: 547 DLNK-EIALQKESLMSLQAQLDKALQKEKHYLQTT-ITKEAY----DALSRKSAACQDDL 600
DLN+ EI L + M+ +A ++Y T I K+ DAL R ++ L
Sbjct: 1627 DLNEMEIQLNHANRMAAEAL--------RNYRNTQGILKDTQIHLDDAL-RSQEDLKEQL 1677
Query: 601 TQALEKLNHVTSETKSLQQSLTQTQEKKAQLEEEIIAYEERMKKLNTELRKLRGFHQESE 660
+ N + +E + L+ +L QT+ + E+E++ ER++ L+T+ L ++ E
Sbjct: 1678 AMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLE 1737
Query: 661 LEVHAFDKKLEEMSCQVLQWQKQHQNDLKMLAAKEEQLREFQEEMAAL---KENLLEDDK 717
++ ++E++ + +++ + + A E+L++ Q+ A L K+N+ + K
Sbjct: 1738 TDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVK 1797
Query: 718 EPCCLPQWSVPKDTCRLYRGNDQIMTNLEQWAKQQKVANEKLGNQLREQVKYIAKLSGEK 777
+ L + L G QI K + E G EQ + + G +
Sbjct: 1798 D---LQLRLDEAEQLALKGGKKQIQ-------KLEARVRELEGEVESEQKRNAEAVKGLR 1847
Query: 778 DREPTRASSPNTTRPSSPSHSHLHSVMVHLQQENKKLKKEIEEKKMKAENTRL 830
E T + L ++ LQ + K K++ EE + + NT L
Sbjct: 1848 KHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAE-EQSNTNL 1899
Score = 109 bits (272), Expect = 1e-23
Identities = 139/733 (18%), Positives = 317/733 (43%), Gaps = 57/733 (7%)
Query: 8 TGEKLHLAQEQLALAGDKIASLERSLNLYRDKYQSSLSNIELLECQVKMLQGELGGIMGQ 67
T +++ +E+ D++A E +K + L L+ QV Q E G+
Sbjct: 851 TEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQV---QAEAEGLADA 907
Query: 68 EPE-NKGDHSKVRIYTSPCMIQEHQETQKRLS-EVWQKVSQQDDLIQELRNKLACSNALV 125
E ++ +K+++ + E E ++ ++ E+ K + +D EL+ + +
Sbjct: 908 EERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTL 967
Query: 126 LEREKALIKLQADFASCTATHRYPPSSSEECEDIKKILKHLQEQKDSQCLHVEEYQNLVK 185
+ EK + + T + + KK L+ +Q E+ N +
Sbjct: 968 AKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLT 1027
Query: 186 DLRVELEAVSEQKRNIMKDMMKLELDLHGLREETSAHIERKDKDITILQCRLQELQLEFT 245
+++LE + ++ KL +DL + + ++ + I ++ Q+L +
Sbjct: 1028 KAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLK 1087
Query: 246 ETQKLTLKKDKFLQEKDEMLQELEKKLTQVQNSLLKKEKELEKQQCMAT----------- 294
+ + ++++ + +L+KK+ ++Q + + E+E+E ++
Sbjct: 1088 KKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSR 1147
Query: 295 ---ELEMTVKEAKQDKSKEAEC-KALQAEVQKLKNSLEEAK-QQERLAAQQAAQCKEEAA 349
E+ ++EA S + E K +AE QK++ LEEA Q E AA + + A
Sbjct: 1148 ELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVA 1207
Query: 350 LAGCHLEDTQRKLQKGLLLDKQKADTIQELQRELQMLQKESSMAEKEQTSNRKRVEELSL 409
G +++ QR QK L+K+K+ E++ E+ L K + +E++
Sbjct: 1208 ELGEQIDNLQRVKQK---LEKEKS----EMKMEIDDLASNVETVSKA----KGNLEKMCR 1256
Query: 410 ELSEALRKLENSDKEKRQLQKTVAEQDMKMNDMLDRIKHQHREQGSIKCKLEEDLQEATK 469
L + L +L++ ++E+++L + Q ++ Q E+ ++ +L Q T+
Sbjct: 1257 TLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQ 1316
Query: 470 LLEDKREQLKKSKEHEKLMEGELEALRQEFKKKDKTLKENSRKLEEENENLRAELQCCST 529
+E+ + QL++ + + + L++ R + L+E + +E L+ L +T
Sbjct: 1317 QIEELKRQLEEEIKAKNALAHALQSSRHDC----DLLREQYEEEQESKAELQRALSKANT 1372
Query: 530 QLESSLNKYNTS----QQVIQDLNKEIALQ----KESLMSLQAQLDKALQKEKHYLQTTI 581
++ KY T + +++ K++A + +E + ++ A+ +L+K K LQ +
Sbjct: 1373 EVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKC-ASLEKTKQRLQNEV 1431
Query: 582 TKEAYDALSRKSAACQDDLTQALEKLNHVTSETKSLQQSLTQTQEKKAQLEEEIIAYEER 641
D + R +AAC AL+K + ++ + L + ++K + E+ A ++
Sbjct: 1432 EDLMLD-VERTNAAC-----AALDK------KQRNFDKILAEWKQKCEETHAELEASQKE 1479
Query: 642 MKKLNTELRKLRGFHQESELEVHAFDKKLEEMSCQVLQWQKQHQNDLKMLAAKEEQLREF 701
+ L TEL K++ ++ES ++ ++ + + ++ +Q K + E+ ++
Sbjct: 1480 ARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQV 1539
Query: 702 QEEMAALKENLLE 714
++E L+ L E
Sbjct: 1540 EQEKCELQAALEE 1552
Score = 99.4 bits (246), Expect = 1e-20
Identities = 144/650 (22%), Positives = 280/650 (43%), Gaps = 90/650 (13%)
Query: 267 ELEKKLTQVQNSLLKKEKELEKQQCMATELE---MTVKEAKQDKSKEAECKALQAEVQKL 323
E EK++ ++ K + EL K + ELE +T+ + K D + +QAE + L
Sbjct: 850 ETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQ-----VQAEAEGL 904
Query: 324 KNSLEEAKQQERLAAQQAAQCKEEAALAGCHLEDTQRKLQKGLLLDKQK-ADTIQELQRE 382
++ E Q + Q A+ KE A + + ++ L K+K D EL+++
Sbjct: 905 ADAEERCDQLIKTKIQLEAKIKEVTERA-----EDEEEINAELTAKKRKLEDECSELKKD 959
Query: 383 LQMLQKESSMAEKEQTSNRKRVEELSLELSEALRKLENSDKEKRQLQK------------ 430
+ L+ + EKE+ + +V+ L+ E++ + KEK+ LQ+
Sbjct: 960 IDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAE 1019
Query: 431 -----TVAEQDMKMNDMLDRIKHQHREQGSI-------KCKLEEDL---QEATKLLEDKR 475
T+ + +K+ +D ++ ++ + K KLE DL QE+ +E+++
Sbjct: 1020 EDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEK 1079
Query: 476 EQLK---KSKEHE-KLMEGELE---ALRQEFKKKDKTLKENSRKLEEENENLRA------ 522
+QL K KE E ++ ++E AL + +KK K L+ +LEEE E RA
Sbjct: 1080 QQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAE 1139
Query: 523 --------ELQCCSTQLESSLNKYNTSQQVIQDLNKEIALQKE----SLMSLQAQLDKAL 570
EL+ S +LE + TS Q+ + +E QK +LQ + A
Sbjct: 1140 KQRSDLSRELEEISERLEEAGGA--TSAQIEMNKKREAEFQKMRRDLEEATLQHEATAAT 1197
Query: 571 QKEKHYLQTTITKEAYDALSRKSAACQDDLTQALEKLNHVTSETKSLQQSLTQTQEKKAQ 630
++KH E D L R + + ++ +++ + S +++ ++ ++
Sbjct: 1198 LRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRT 1257
Query: 631 LEE---EIIAYEERMKKLNTELRKLRGFHQESELEVHAFDKKLEEMSCQVLQWQKQHQND 687
LE+ E+ + EE ++L +L RG + E F ++L+E V Q + Q
Sbjct: 1258 LEDQLSELKSKEEEQQRLINDLTAQRG---RLQTESGEFSRQLDEKEALVSQLSRGKQAF 1314
Query: 688 LKMLAAKEEQLREFQEEMAALK--ENLLEDDKEPCCL--PQWSVPKDT-CRLYRGNDQIM 742
+ + EE R+ +EE+ A + L+ + C L Q+ +++ L R +
Sbjct: 1315 TQQI---EELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKAN 1371
Query: 743 TNLEQWAKQQKVANEKLGNQLREQVKYIAK--LSGEKDREPTRASSPNTTRPSSPSHSHL 800
T + QW + + + +L E K +A+ + E+ E A + + + +
Sbjct: 1372 TEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEV 1431
Query: 801 HSVMVHLQQENKKL----KKEIEEKKMKAENTRLCTKALGPSRTESTQRE 846
+M+ +++ N KK+ K+ AE + C + + E++Q+E
Sbjct: 1432 EDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEET--HAELEASQKE 1479
Score = 92.4 bits (228), Expect = 2e-18
Identities = 147/698 (21%), Positives = 303/698 (43%), Gaps = 79/698 (11%)
Query: 28 SLERSLNLYRDKYQSSLSNIELLECQVKMLQGELGGIMGQEPENKGDHSKV--------- 78
+LE L+ + K + I L Q LQ E G Q E + S++
Sbjct: 1257 TLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQ 1316
Query: 79 RIYTSPCMIQEHQETQKRLSEVWQKVSQQDDLIQELRNKLACSNALVLEREKALIKLQAD 138
+I ++E + + L+ Q DL++E + S A E ++AL K +
Sbjct: 1317 QIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKA---ELQRALSKANTE 1373
Query: 139 FASCTATHRYPP-SSSEECEDIKKIL-KHLQ------EQKDSQCLHVEE----YQNLVKD 186
A + +EE E+ KK L + LQ E +++C +E+ QN V+D
Sbjct: 1374 VAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVED 1433
Query: 187 LRVELE-------AVSEQKRNIMKDMMKLELDLHGLREETSAHIERKDKDITILQCRLQE 239
L +++E A+ +++RN K + + + EET A +E K+ L L +
Sbjct: 1434 LMLDVERTNAACAALDKKQRNFDKILAEWKQKC----EETHAELEASQKEARSLGTELFK 1489
Query: 240 LQLEFTET--QKLTLKKD-KFLQEKDEMLQELEKKLTQVQNSLLKKEKELEKQQCMATEL 296
++ + E+ Q TLK++ K LQ++ L E + + + L K +K++E+++C EL
Sbjct: 1490 IKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKC---EL 1546
Query: 297 EMTVKEAKQD-KSKEAECKALQAEVQKLKNSLEE--AKQQERLAAQQAAQCKEEAALAGC 353
+ ++EA+ + +E + +Q E+ ++K+ ++ A++ E + + + ++
Sbjct: 1547 QAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQST 1606
Query: 354 HLEDTQRKLQKGLLLDKQKADTIQELQRELQMLQKESSMAEKEQTSNRKRVEELSLELSE 413
L+ R + L K+ + E++ +L + ++ A + + + +++ + L +
Sbjct: 1607 -LDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDD 1665
Query: 414 ALRKLENSDK-----------------------EKRQLQKTVAEQDMKMNDMLDRIKHQH 450
ALR E+ + E+ + + +AEQ++ D +R++ H
Sbjct: 1666 ALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELL--DASERVQLLH 1723
Query: 451 REQGSI---KCKLEEDLQEATKLLEDKREQLKKSKEHEKLMEGELEALRQEFKKKDKTLK 507
+ S+ K KLE D+ + +ED ++ + ++E K + + +E KK+ T
Sbjct: 1724 TQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDT-S 1782
Query: 508 ENSRKLEEENENLRAELQCCSTQLESSLNKYNTSQ-QVIQDLNKEIALQKESLMSLQAQL 566
+ ++++ E +LQ + E K Q Q ++ +E+ + ES A+
Sbjct: 1783 AHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEA 1842
Query: 567 DKALQKEKHYLQTTITKEAYDALSRKSAACQDDLTQALE-KLNHVTSETKSLQQSLTQTQ 625
K L+K + ++ + D RK+ DL L+ K+ + + ++
Sbjct: 1843 VKGLRKHERRVKELTYQTEED---RKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNL 1899
Query: 626 EKKAQLEEEIIAYEERMKKLNTELRKLRGFHQESELEV 663
K +L+ E+ EER +++ KLR +E +V
Sbjct: 1900 AKFRKLQHELEEAEERADIAESQVNKLRVKSREVHTKV 1937
Score = 77.8 bits (190), Expect = 4e-14
Identities = 107/514 (20%), Positives = 223/514 (43%), Gaps = 77/514 (14%)
Query: 10 EKLHLAQEQLALAGDKIASLERSLNLYRDKYQSSLSNIELLECQVKMLQGELGGIMGQEP 69
+K +L + + SL L ++ Y+ SL +E L+ + K LQ E+ + Q
Sbjct: 1464 QKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIA 1523
Query: 70 EN-KGDHS----KVRIYTSPCMIQ----------EHQETQ---------KRLSEVWQKVS 105
E K H K ++ C +Q EH+E + + SEV +K++
Sbjct: 1524 EGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIA 1583
Query: 106 QQDDLIQELRNKLACSNALVLEREKALIKLQADFASCTATHRYPPSSSEECEDIKKILKH 165
++D+ I +L+ ++ ++E ++ L A+ S R + +++ L H
Sbjct: 1584 EKDEEIDQLKR----NHIRIVESMQST--LDAEIRSRNDAIRLKKKMEGDLNEMEIQLNH 1637
Query: 166 LQEQKDSQCLHVEEYQNLVKDLRVELEAVSEQKRNIMKDMMKLELDLHGLREETSAHIER 225
+ Q ++KD ++ L+ D ++ + DL +E A +ER
Sbjct: 1638 ANRMAAEALRNYRNTQGILKDTQIHLD-----------DALRSQEDL----KEQLAMVER 1682
Query: 226 KDKDITILQCRLQELQLEFTETQKLTLKKDKFLQEKDEMLQELEKKLTQVQNSLLKKEKE 285
+ +LQ ++EL+ +T++ ++ L + E +Q L + T + N+ K E +
Sbjct: 1683 R---ANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETD 1739
Query: 286 LEKQQCMATELEMTVKEAKQDKSKEAECKALQAEVQKLKNSLEEAKQQERLAAQQAAQCK 345
+ + Q ++ + A++ K A+ AE +LK + + ER+
Sbjct: 1740 ISQMQGEMEDILQEARNAEEKAKKAITDAAMMAE--ELKKEQDTSAHLERMKK------- 1790
Query: 346 EEAALAGCHLEDTQRKLQKGLLLDKQKADTIQELQRELQMLQKESSMAEKEQTSNRKRVE 405
++E T + LQ L LD+ + ++ ++++Q L+ E E S +KR
Sbjct: 1791 --------NMEQTVKDLQ--LRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKR-- 1838
Query: 406 ELSLELSEALRKLENSDKEKRQLQKTVAEQDMKMNDMLDRIKHQHREQGSIKCKLEE-DL 464
+ E + LRK E KE + + +++ D++D+++ + + S K + EE +
Sbjct: 1839 --NAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVK---SYKRQAEEAEE 1893
Query: 465 QEATKLLEDKR--EQLKKSKEHEKLMEGELEALR 496
Q T L + ++ +L++++E + E ++ LR
Sbjct: 1894 QSNTNLAKFRKLQHELEEAEERADIAESQVNKLR 1927
Score = 73.2 bits (178), Expect = 1e-12
Identities = 93/448 (20%), Positives = 200/448 (44%), Gaps = 39/448 (8%)
Query: 409 LELSEALRKLENSDKEKRQLQKTVAEQDMKMNDMLDRIKHQHREQGSIKCKLEEDLQEAT 468
L+ +E +++ +E ++++ +A+ + K ++ +++ +E+ ++ +++ + E
Sbjct: 846 LKSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEA-EGL 904
Query: 469 KLLEDKREQLKKSKEHEKLMEGELEALRQEFKKKDKTLKENSRKLEEENENLRAELQCCS 528
E++ +QL K+K + E+ ++ ++ + L RKLE+E L+ ++
Sbjct: 905 ADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLE 964
Query: 529 TQLESSLNKYNTSQQVIQDLNKEIALQKESLMSLQAQLDKALQKEKHYLQTTITKEAYDA 588
L + + ++ +++L +E+A E++ L + KALQ E H Q T+
Sbjct: 965 LTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKE-KKALQ-EAH--QQTL------- 1013
Query: 589 LSRKSAACQDDLTQALEKLNHVTSETKSLQQSLTQTQEKKAQLEEEIIAYEERMKKLNTE 648
DDL +K+N +T L+Q + + Q ++ + E +KL +
Sbjct: 1014 ---------DDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGD 1064
Query: 649 LRKLRGFHQESELEVHAFDKKLEEMSCQVLQWQKQHQNDLKMLAAKEEQLREFQEEMAAL 708
L+ + + E E D+KL++ ++ Q + +++ + +++++E Q A +
Sbjct: 1065 LKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQ---ARI 1121
Query: 709 KENLLEDDKEPCCLPQWSVPKDTCRLYRGNDQIMTNLEQWAKQQKVANEKLGNQLREQVK 768
+E LE++ E + K L R ++I LE+ E N+ RE
Sbjct: 1122 EE--LEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEM--NKKREAEF 1177
Query: 769 YIAKLSGEKDREPTRASSPNTTRPSSPSHSHLHSVMVHLQQENKKLKKEIEEKKMK---- 824
+ E+ A++ + + S + L + +LQ+ +KL+KE E KM+
Sbjct: 1178 QKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDL 1237
Query: 825 AENTRLCTKALGPSRTESTQREKVCGTL 852
A N +KA G EK+C TL
Sbjct: 1238 ASNVETVSKAKG-------NLEKMCRTL 1258
>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 119 bits (299), Expect = 9e-27
Identities = 198/893 (22%), Positives = 387/893 (43%), Gaps = 132/893 (14%)
Query: 12 LHLAQEQLALAGDKIASLERSLNLYRDKYQSSLSNIE-------LLECQVKMLQGELGGI 64
L LAQE + ++ L+ L + + S IE L+ ++K LQ + +
Sbjct: 1065 LKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEEL 1124
Query: 65 MGQEPENKGDHSKVRIYTSPCMIQEHQETQKRLSEVWQKVSQQDDLIQELRNKLACSNAL 124
+ + +K S + +E +E +RL E S Q ++ NK +
Sbjct: 1125 EEEIEAERASRAKAEKQRSD-LSRELEEISERLEEAGGATSAQIEM-----NKKREAEFQ 1178
Query: 125 VLEREKALIKLQADFASCTATHRYPPSSSE---ECEDIKKILKHLQEQKDSQCLHVEEYQ 181
+ R+ LQ + + T ++ S +E + ++++++ + L+++K + ++
Sbjct: 1179 KMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEID--- 1235
Query: 182 NLVKDLRVELEAVSEQKRNIMKDMMKLELDLHGLREETSAHIERKDKDITILQCRLQELQ 241
DL +E VS+ K N+ K LE L L+ + +R D+T + RLQ
Sbjct: 1236 ----DLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQ-QRLINDLTAQRGRLQTES 1290
Query: 242 LEFTE--------TQKLTLKKDKFLQEKDEMLQELEKKLTQVQNSL------------LK 281
EF+ +L+ K F Q+ +E+ ++LE+++ + +N+L L
Sbjct: 1291 GEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEI-KAKNALAHALQSSRHDCDLL 1349
Query: 282 KEKELEKQQCMATELEMTVKEAKQDKSK---EAECKALQAEVQKLKNSLEEAKQQ--ERL 336
+E+ E+Q+ A EL+ + +A + ++ + E A+Q + LEEAK++ +RL
Sbjct: 1350 REQYEEEQESKA-ELQRALSKANTEVAQWRTKYETDAIQRTEE-----LEEAKKKLAQRL 1403
Query: 337 AAQQAAQCKEEAALAGC-HLEDTQRKLQ---KGLLLDKQKADTI---------------- 376
QAA+ EA A C LE T+++LQ + L+LD ++ +
Sbjct: 1404 ---QAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILA 1460
Query: 377 ------QELQRELQMLQKESSMAEKEQTSNRKRVEELSLELSEALRKLENSDKEKRQLQK 430
+E EL+ QKE+ E + EE +L R+ +N +E L +
Sbjct: 1461 EWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTE 1520
Query: 431 TVAEQDMKMNDMLDRIKHQHREQGSIKCKLEEDLQEATKLLEDKREQLKKSKEHEKLMEG 490
+AE ++++ L++IK Q ++ KC+L+ L+EA LE E K++
Sbjct: 1521 QIAEGGKRIHE-LEKIKKQVEQE---KCELQAALEEAEASLEH---------EEGKILRI 1567
Query: 491 ELEALRQEFKKKDKTLKENSRKLEEENENLRAELQCCSTQLESSLNKYNTS----QQVIQ 546
+LE L Q + D+ + E ++++ N ++ + L++ + N + +++
Sbjct: 1568 QLE-LNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEG 1626
Query: 547 DLNK-EIALQKESLMSLQAQLDKALQKEKHYLQTT-ITKEAY----DALSRKSAACQDDL 600
DLN+ EI L + M+ +A ++Y T I K+ DAL R ++ L
Sbjct: 1627 DLNEMEIQLNHANRMAAEAL--------RNYRNTQGILKDTQIHLDDAL-RSQEDLKEQL 1677
Query: 601 TQALEKLNHVTSETKSLQQSLTQTQEKKAQLEEEIIAYEERMKKLNTELRKLRGFHQESE 660
+ N + +E + L+ +L QT+ + E+E++ ER++ L+T+ L ++ E
Sbjct: 1678 AMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLE 1737
Query: 661 LEVHAFDKKLEEMSCQVLQWQKQHQNDLKMLAAKEEQLREFQEEMAAL---KENLLEDDK 717
++ ++E++ + +++ + + A E+L++ Q+ A L K+N+ + K
Sbjct: 1738 TDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVK 1797
Query: 718 EPCCLPQWSVPKDTCRLYRGNDQIMTNLEQWAKQQKVANEKLGNQLREQVKYIAKLSGEK 777
+ L + L G QI K + E G EQ + + G +
Sbjct: 1798 D---LQLRLDEAEQLALKGGKKQIQ-------KLEARVRELEGEVESEQKRNAEAVKGLR 1847
Query: 778 DREPTRASSPNTTRPSSPSHSHLHSVMVHLQQENKKLKKEIEEKKMKAENTRL 830
E T + L ++ LQ + K K++ EE + + NT L
Sbjct: 1848 KHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAE-EQSNTNL 1899
Score = 109 bits (272), Expect = 1e-23
Identities = 139/733 (18%), Positives = 317/733 (43%), Gaps = 57/733 (7%)
Query: 8 TGEKLHLAQEQLALAGDKIASLERSLNLYRDKYQSSLSNIELLECQVKMLQGELGGIMGQ 67
T +++ +E+ D++A E +K + L L+ QV Q E G+
Sbjct: 851 TEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQV---QAEAEGLADA 907
Query: 68 EPE-NKGDHSKVRIYTSPCMIQEHQETQKRLS-EVWQKVSQQDDLIQELRNKLACSNALV 125
E ++ +K+++ + E E ++ ++ E+ K + +D EL+ + +
Sbjct: 908 EERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTL 967
Query: 126 LEREKALIKLQADFASCTATHRYPPSSSEECEDIKKILKHLQEQKDSQCLHVEEYQNLVK 185
+ EK + + T + + KK L+ +Q E+ N +
Sbjct: 968 AKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLT 1027
Query: 186 DLRVELEAVSEQKRNIMKDMMKLELDLHGLREETSAHIERKDKDITILQCRLQELQLEFT 245
+++LE + ++ KL +DL + + ++ + I ++ Q+L +
Sbjct: 1028 KAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLK 1087
Query: 246 ETQKLTLKKDKFLQEKDEMLQELEKKLTQVQNSLLKKEKELEKQQCMAT----------- 294
+ + ++++ + +L+KK+ ++Q + + E+E+E ++
Sbjct: 1088 KKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSR 1147
Query: 295 ---ELEMTVKEAKQDKSKEAEC-KALQAEVQKLKNSLEEAK-QQERLAAQQAAQCKEEAA 349
E+ ++EA S + E K +AE QK++ LEEA Q E AA + + A
Sbjct: 1148 ELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVA 1207
Query: 350 LAGCHLEDTQRKLQKGLLLDKQKADTIQELQRELQMLQKESSMAEKEQTSNRKRVEELSL 409
G +++ QR QK L+K+K+ E++ E+ L K + +E++
Sbjct: 1208 ELGEQIDNLQRVKQK---LEKEKS----EMKMEIDDLASNVETVSKA----KGNLEKMCR 1256
Query: 410 ELSEALRKLENSDKEKRQLQKTVAEQDMKMNDMLDRIKHQHREQGSIKCKLEEDLQEATK 469
L + L +L++ ++E+++L + Q ++ Q E+ ++ +L Q T+
Sbjct: 1257 TLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQ 1316
Query: 470 LLEDKREQLKKSKEHEKLMEGELEALRQEFKKKDKTLKENSRKLEEENENLRAELQCCST 529
+E+ + QL++ + + + L++ R + L+E + +E L+ L +T
Sbjct: 1317 QIEELKRQLEEEIKAKNALAHALQSSRHDC----DLLREQYEEEQESKAELQRALSKANT 1372
Query: 530 QLESSLNKYNTS----QQVIQDLNKEIALQ----KESLMSLQAQLDKALQKEKHYLQTTI 581
++ KY T + +++ K++A + +E + ++ A+ +L+K K LQ +
Sbjct: 1373 EVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKC-ASLEKTKQRLQNEV 1431
Query: 582 TKEAYDALSRKSAACQDDLTQALEKLNHVTSETKSLQQSLTQTQEKKAQLEEEIIAYEER 641
D + R +AAC AL+K + ++ + L + ++K + E+ A ++
Sbjct: 1432 EDLMLD-VERTNAAC-----AALDK------KQRNFDKILAEWKQKCEETHAELEASQKE 1479
Query: 642 MKKLNTELRKLRGFHQESELEVHAFDKKLEEMSCQVLQWQKQHQNDLKMLAAKEEQLREF 701
+ L TEL K++ ++ES ++ ++ + + ++ +Q K + E+ ++
Sbjct: 1480 ARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQV 1539
Query: 702 QEEMAALKENLLE 714
++E L+ L E
Sbjct: 1540 EQEKCELQAALEE 1552
Score = 99.4 bits (246), Expect = 1e-20
Identities = 144/650 (22%), Positives = 280/650 (43%), Gaps = 90/650 (13%)
Query: 267 ELEKKLTQVQNSLLKKEKELEKQQCMATELE---MTVKEAKQDKSKEAECKALQAEVQKL 323
E EK++ ++ K + EL K + ELE +T+ + K D + +QAE + L
Sbjct: 850 ETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQ-----VQAEAEGL 904
Query: 324 KNSLEEAKQQERLAAQQAAQCKEEAALAGCHLEDTQRKLQKGLLLDKQK-ADTIQELQRE 382
++ E Q + Q A+ KE A + + ++ L K+K D EL+++
Sbjct: 905 ADAEERCDQLIKTKIQLEAKIKEVTERA-----EDEEEINAELTAKKRKLEDECSELKKD 959
Query: 383 LQMLQKESSMAEKEQTSNRKRVEELSLELSEALRKLENSDKEKRQLQK------------ 430
+ L+ + EKE+ + +V+ L+ E++ + KEK+ LQ+
Sbjct: 960 IDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAE 1019
Query: 431 -----TVAEQDMKMNDMLDRIKHQHREQGSI-------KCKLEEDL---QEATKLLEDKR 475
T+ + +K+ +D ++ ++ + K KLE DL QE+ +E+++
Sbjct: 1020 EDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEK 1079
Query: 476 EQLK---KSKEHE-KLMEGELE---ALRQEFKKKDKTLKENSRKLEEENENLRA------ 522
+QL K KE E ++ ++E AL + +KK K L+ +LEEE E RA
Sbjct: 1080 QQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAE 1139
Query: 523 --------ELQCCSTQLESSLNKYNTSQQVIQDLNKEIALQKE----SLMSLQAQLDKAL 570
EL+ S +LE + TS Q+ + +E QK +LQ + A
Sbjct: 1140 KQRSDLSRELEEISERLEEAGGA--TSAQIEMNKKREAEFQKMRRDLEEATLQHEATAAT 1197
Query: 571 QKEKHYLQTTITKEAYDALSRKSAACQDDLTQALEKLNHVTSETKSLQQSLTQTQEKKAQ 630
++KH E D L R + + ++ +++ + S +++ ++ ++
Sbjct: 1198 LRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRT 1257
Query: 631 LEE---EIIAYEERMKKLNTELRKLRGFHQESELEVHAFDKKLEEMSCQVLQWQKQHQND 687
LE+ E+ + EE ++L +L RG + E F ++L+E V Q + Q
Sbjct: 1258 LEDQLSELKSKEEEQQRLINDLTAQRG---RLQTESGEFSRQLDEKEALVSQLSRGKQAF 1314
Query: 688 LKMLAAKEEQLREFQEEMAALK--ENLLEDDKEPCCL--PQWSVPKDT-CRLYRGNDQIM 742
+ + EE R+ +EE+ A + L+ + C L Q+ +++ L R +
Sbjct: 1315 TQQI---EELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKAN 1371
Query: 743 TNLEQWAKQQKVANEKLGNQLREQVKYIAK--LSGEKDREPTRASSPNTTRPSSPSHSHL 800
T + QW + + + +L E K +A+ + E+ E A + + + +
Sbjct: 1372 TEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEV 1431
Query: 801 HSVMVHLQQENKKL----KKEIEEKKMKAENTRLCTKALGPSRTESTQRE 846
+M+ +++ N KK+ K+ AE + C + + E++Q+E
Sbjct: 1432 EDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEET--HAELEASQKE 1479
Score = 92.4 bits (228), Expect = 2e-18
Identities = 147/698 (21%), Positives = 303/698 (43%), Gaps = 79/698 (11%)
Query: 28 SLERSLNLYRDKYQSSLSNIELLECQVKMLQGELGGIMGQEPENKGDHSKV--------- 78
+LE L+ + K + I L Q LQ E G Q E + S++
Sbjct: 1257 TLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQ 1316
Query: 79 RIYTSPCMIQEHQETQKRLSEVWQKVSQQDDLIQELRNKLACSNALVLEREKALIKLQAD 138
+I ++E + + L+ Q DL++E + S A E ++AL K +
Sbjct: 1317 QIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKA---ELQRALSKANTE 1373
Query: 139 FASCTATHRYPP-SSSEECEDIKKIL-KHLQ------EQKDSQCLHVEE----YQNLVKD 186
A + +EE E+ KK L + LQ E +++C +E+ QN V+D
Sbjct: 1374 VAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVED 1433
Query: 187 LRVELE-------AVSEQKRNIMKDMMKLELDLHGLREETSAHIERKDKDITILQCRLQE 239
L +++E A+ +++RN K + + + EET A +E K+ L L +
Sbjct: 1434 LMLDVERTNAACAALDKKQRNFDKILAEWKQKC----EETHAELEASQKEARSLGTELFK 1489
Query: 240 LQLEFTET--QKLTLKKD-KFLQEKDEMLQELEKKLTQVQNSLLKKEKELEKQQCMATEL 296
++ + E+ Q TLK++ K LQ++ L E + + + L K +K++E+++C EL
Sbjct: 1490 IKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKC---EL 1546
Query: 297 EMTVKEAKQD-KSKEAECKALQAEVQKLKNSLEE--AKQQERLAAQQAAQCKEEAALAGC 353
+ ++EA+ + +E + +Q E+ ++K+ ++ A++ E + + + ++
Sbjct: 1547 QAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQST 1606
Query: 354 HLEDTQRKLQKGLLLDKQKADTIQELQRELQMLQKESSMAEKEQTSNRKRVEELSLELSE 413
L+ R + L K+ + E++ +L + ++ A + + + +++ + L +
Sbjct: 1607 -LDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDD 1665
Query: 414 ALRKLENSDK-----------------------EKRQLQKTVAEQDMKMNDMLDRIKHQH 450
ALR E+ + E+ + + +AEQ++ D +R++ H
Sbjct: 1666 ALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELL--DASERVQLLH 1723
Query: 451 REQGSI---KCKLEEDLQEATKLLEDKREQLKKSKEHEKLMEGELEALRQEFKKKDKTLK 507
+ S+ K KLE D+ + +ED ++ + ++E K + + +E KK+ T
Sbjct: 1724 TQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDT-S 1782
Query: 508 ENSRKLEEENENLRAELQCCSTQLESSLNKYNTSQ-QVIQDLNKEIALQKESLMSLQAQL 566
+ ++++ E +LQ + E K Q Q ++ +E+ + ES A+
Sbjct: 1783 AHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEA 1842
Query: 567 DKALQKEKHYLQTTITKEAYDALSRKSAACQDDLTQALE-KLNHVTSETKSLQQSLTQTQ 625
K L+K + ++ + D RK+ DL L+ K+ + + ++
Sbjct: 1843 VKGLRKHERRVKELTYQTEED---RKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNL 1899
Query: 626 EKKAQLEEEIIAYEERMKKLNTELRKLRGFHQESELEV 663
K +L+ E+ EER +++ KLR +E +V
Sbjct: 1900 AKFRKLQHELEEAEERADIAESQVNKLRVKSREVHTKV 1937
Score = 77.8 bits (190), Expect = 4e-14
Identities = 107/514 (20%), Positives = 223/514 (43%), Gaps = 77/514 (14%)
Query: 10 EKLHLAQEQLALAGDKIASLERSLNLYRDKYQSSLSNIELLECQVKMLQGELGGIMGQEP 69
+K +L + + SL L ++ Y+ SL +E L+ + K LQ E+ + Q
Sbjct: 1464 QKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIA 1523
Query: 70 EN-KGDHS----KVRIYTSPCMIQ----------EHQETQ---------KRLSEVWQKVS 105
E K H K ++ C +Q EH+E + + SEV +K++
Sbjct: 1524 EGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIA 1583
Query: 106 QQDDLIQELRNKLACSNALVLEREKALIKLQADFASCTATHRYPPSSSEECEDIKKILKH 165
++D+ I +L+ ++ ++E ++ L A+ S R + +++ L H
Sbjct: 1584 EKDEEIDQLKR----NHIRIVESMQST--LDAEIRSRNDAIRLKKKMEGDLNEMEIQLNH 1637
Query: 166 LQEQKDSQCLHVEEYQNLVKDLRVELEAVSEQKRNIMKDMMKLELDLHGLREETSAHIER 225
+ Q ++KD ++ L+ D ++ + DL +E A +ER
Sbjct: 1638 ANRMAAEALRNYRNTQGILKDTQIHLD-----------DALRSQEDL----KEQLAMVER 1682
Query: 226 KDKDITILQCRLQELQLEFTETQKLTLKKDKFLQEKDEMLQELEKKLTQVQNSLLKKEKE 285
+ +LQ ++EL+ +T++ ++ L + E +Q L + T + N+ K E +
Sbjct: 1683 R---ANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETD 1739
Query: 286 LEKQQCMATELEMTVKEAKQDKSKEAECKALQAEVQKLKNSLEEAKQQERLAAQQAAQCK 345
+ + Q ++ + A++ K A+ AE +LK + + ER+
Sbjct: 1740 ISQMQGEMEDILQEARNAEEKAKKAITDAAMMAE--ELKKEQDTSAHLERMKK------- 1790
Query: 346 EEAALAGCHLEDTQRKLQKGLLLDKQKADTIQELQRELQMLQKESSMAEKEQTSNRKRVE 405
++E T + LQ L LD+ + ++ ++++Q L+ E E S +KR
Sbjct: 1791 --------NMEQTVKDLQ--LRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKR-- 1838
Query: 406 ELSLELSEALRKLENSDKEKRQLQKTVAEQDMKMNDMLDRIKHQHREQGSIKCKLEE-DL 464
+ E + LRK E KE + + +++ D++D+++ + + S K + EE +
Sbjct: 1839 --NAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVK---SYKRQAEEAEE 1893
Query: 465 QEATKLLEDKR--EQLKKSKEHEKLMEGELEALR 496
Q T L + ++ +L++++E + E ++ LR
Sbjct: 1894 QSNTNLAKFRKLQHELEEAEERADIAESQVNKLR 1927
Score = 73.2 bits (178), Expect = 1e-12
Identities = 93/448 (20%), Positives = 200/448 (44%), Gaps = 39/448 (8%)
Query: 409 LELSEALRKLENSDKEKRQLQKTVAEQDMKMNDMLDRIKHQHREQGSIKCKLEEDLQEAT 468
L+ +E +++ +E ++++ +A+ + K ++ +++ +E+ ++ +++ + E
Sbjct: 846 LKSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEA-EGL 904
Query: 469 KLLEDKREQLKKSKEHEKLMEGELEALRQEFKKKDKTLKENSRKLEEENENLRAELQCCS 528
E++ +QL K+K + E+ ++ ++ + L RKLE+E L+ ++
Sbjct: 905 ADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLE 964
Query: 529 TQLESSLNKYNTSQQVIQDLNKEIALQKESLMSLQAQLDKALQKEKHYLQTTITKEAYDA 588
L + + ++ +++L +E+A E++ L + KALQ E H Q T+
Sbjct: 965 LTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKE-KKALQ-EAH--QQTL------- 1013
Query: 589 LSRKSAACQDDLTQALEKLNHVTSETKSLQQSLTQTQEKKAQLEEEIIAYEERMKKLNTE 648
DDL +K+N +T L+Q + + Q ++ + E +KL +
Sbjct: 1014 ---------DDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGD 1064
Query: 649 LRKLRGFHQESELEVHAFDKKLEEMSCQVLQWQKQHQNDLKMLAAKEEQLREFQEEMAAL 708
L+ + + E E D+KL++ ++ Q + +++ + +++++E Q A +
Sbjct: 1065 LKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQ---ARI 1121
Query: 709 KENLLEDDKEPCCLPQWSVPKDTCRLYRGNDQIMTNLEQWAKQQKVANEKLGNQLREQVK 768
+E LE++ E + K L R ++I LE+ E N+ RE
Sbjct: 1122 EE--LEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEM--NKKREAEF 1177
Query: 769 YIAKLSGEKDREPTRASSPNTTRPSSPSHSHLHSVMVHLQQENKKLKKEIEEKKMK---- 824
+ E+ A++ + + S + L + +LQ+ +KL+KE E KM+
Sbjct: 1178 QKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDL 1237
Query: 825 AENTRLCTKALGPSRTESTQREKVCGTL 852
A N +KA G EK+C TL
Sbjct: 1238 ASNVETVSKAKG-------NLEKMCRTL 1258
>gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo sapiens]
Length = 1498
Score = 119 bits (299), Expect = 9e-27
Identities = 202/930 (21%), Positives = 383/930 (41%), Gaps = 110/930 (11%)
Query: 9 GEKLHLAQEQLALAGD----KIASLERSLNLYRDKYQSSLSNIELLECQVKMLQGELGGI 64
GE H+ Q+ AG K+ ++ S L +++S + LQG +
Sbjct: 594 GEMAHIQVGQMTQAGLLEHLKLENVSLSQQLTETQHRSMKEKGRI----AAQLQGIEADM 649
Query: 65 MGQEPENKGDHSKVRIYTSPCMIQEHQETQKRLSEVW---QKVSQQDDLIQELRNKLACS 121
+ QE + ++I + M++E + Q+RL E +++ + D L +L
Sbjct: 650 LDQEA------AFMQIQEAKTMVEE--DLQRRLEEFEGERERLQRMADSAASLEQQLEQV 701
Query: 122 NALVLEREKALIKLQAD----FASCTATHRYPPSSSEECEDIKKILKHLQE---QKDSQC 174
+L+R++ L LQ + T T S + + ++ LQ + +
Sbjct: 702 KLTLLQRDQQLEALQQEHLDLMKQLTLTQEALQSREQSLDALQTHYDELQARLGELQGEA 761
Query: 175 LHVEEYQNLVKDLRVELEAVSEQKRNIMKDMMKLELDLHGLREETSAHIERKDKDITILQ 234
E+ L+++ ++ LEA + ++ +++ + L EETS +E+ +++ I
Sbjct: 762 ASREDTICLLQNEKIILEAALQAAKSGKEELDRGARRLEEGTEETSETLEKLREELAIKS 821
Query: 235 CRLQELQLEFTETQKLTLK-KDKFLQEK-------------DEMLQELEKKLTQVQNSLL 280
+++ LQ E +K K K++FLQ+K D+++ EL+ ++ + L
Sbjct: 822 GQVEHLQQETAALKKQMQKIKEQFLQQKVMVEAYRRDATSKDQLISELKATRKRLDSELK 881
Query: 281 KKEKEL-----EKQQCMATELEMTVKEAKQDKSKEAECKALQAEVQKLKNSLEEAKQQER 335
+ +EL EK+ A EL +E Q + A+ + QK ++ +E Q +
Sbjct: 882 ELRQELMQVHGEKRTAEA-ELSRLHREVAQVRQHMADLEGHLQSAQKERDEMETHLQSLQ 940
Query: 336 LAAQQAAQCKEEAALAGCHLEDTQRKLQKGLLLDKQKADTIQELQRELQMLQKESSMAEK 395
+Q E +E+ Q++ +K + KQK ++ L + + A+K
Sbjct: 941 FDKEQMVAVTEANEALKKQIEELQQEARKAITEQKQK----------MRRLGSDLTSAQK 990
Query: 396 EQTSNRKRVEE----LSLELSEALRKLENSDKEKRQLQKTVAEQD--MKMNDMLDRIKHQ 449
E + K E LS L EAL E +D E QL+ D + +++ + ++ +
Sbjct: 991 EMKTKHKAYENAVGILSRRLQEALAAKEAADAELGQLRAQGGSSDSSLALHERIQALEAE 1050
Query: 450 HREQGSIKCKLEEDLQEATKLLEDKREQLKKSKEHEKLMEGELEALRQEFKKKDKTLKEN 509
+ K LE++LQE L ++L++S+E +E EL+ R F+KK K L+E+
Sbjct: 1051 LQAVSHSKTLLEKELQEVIALTS---QELEESREKVLELEDELQESRG-FRKKIKRLEES 1106
Query: 510 SRKLEEENENLR----------AELQCCSTQLESSLNKYNTS--------QQVIQDLNKE 551
++KL E E+ + A L+ ++ LE++L K Q V+Q +E
Sbjct: 1107 NKKLALELEHEKGKLTGLGQSNAALREHNSILETALAKREADLVQLNLQVQAVLQRKEEE 1166
Query: 552 IALQKESLMSLQAQLDKALQKEKHYLQTTITKEAYDALSRKS-AACQDDLTQALEKLNHV 610
K + +LQA L+K +K + + +R+ A +L++ ++L
Sbjct: 1167 DRQMKHLVQALQASLEKEKEKVNSLKEQVAAAKVEAGHNRRHFKAASLELSEVKKELQAK 1226
Query: 611 TSETKSLQQSLTQTQEKKAQLEEEIIAYEERM-----------KKLNTELRKLRGFHQES 659
+ LQ Q ++ + +EI ++ + K+L+ +L K +QE
Sbjct: 1227 EHLVQKLQAEADDLQIREGKHSQEIAQFQAELAEARAQLQLLQKQLDEQLSKQPVGNQEM 1286
Query: 660 ELEVHAFDKKLEEMSCQVLQWQKQHQNDLKMLAAKEEQLREFQEEMAALKENLLEDDKEP 719
E D+K E+ Q Q K L ++ L+ + E+ +E+L K+
Sbjct: 1287 ENLKWEVDQKEREIQSLKQQLDLTEQQGRKELEGLQQLLQNVKSELEMAQEDLSMTQKDK 1346
Query: 720 CCL-PQWSVPKDTCR-LYRGNDQIMTNLEQWAKQQKVANEKLGNQLREQVKYIAKLSGEK 777
L + S K+ + L + N Q+ +L + A K E G K+
Sbjct: 1347 FMLQAKVSELKNNMKTLLQQNQQLKLDLRRGA--AKTRKEPKGEASSSNPATPIKI---P 1401
Query: 778 DREPTRASSPNTTRP----SSPSHSHLHSVMVHLQQENKKLKKEIEEKKMKAENTRLCTK 833
D + RP S +L+S + L+QE L++++EE + +
Sbjct: 1402 DCPVPASLLEELLRPPPAVSKEPLKNLNSCLQQLKQEMDSLQRQMEEHALTVHESLSSWT 1461
Query: 834 ALGPSRTESTQREKVCGTLGWKGLPQDMGQ 863
L P+ G G +G PQ Q
Sbjct: 1462 PLEPATASPVPPG---GHAGPRGDPQRHSQ 1488
Score = 98.6 bits (244), Expect = 2e-20
Identities = 162/749 (21%), Positives = 307/749 (40%), Gaps = 120/749 (16%)
Query: 107 QDDLIQELRNKLACSN---ALVLEREKALIKLQADFASCTATHRYPPSSSEECEDIKKIL 163
Q++++Q L+ K+ AL LE +AL K +A+ + A + EC
Sbjct: 404 QEEMLQVLKEKMRLEGQLEALSLEASQAL-KEKAELQAQLAALSTKLQAQVECSHSS--- 459
Query: 164 KHLQEQKDSQCLHVEEYQNLVKDLRVELEAVSEQKRNIMKDMMKLELDLHGLREETSAHI 223
Q+++DS V+ + DL + DL + E +A +
Sbjct: 460 ---QQRQDSLSSEVDTLKQSCWDLE------------------RAMTDLQNMLEAKNASL 498
Query: 224 ERKDKDITILQCRLQELQLEFTETQKLTLKKDKFLQEKDEMLQELEKKLTQVQNSLLKKE 283
+ D+ + + + Q L + + Q+ L KD + + + + L+ +L QVQ
Sbjct: 499 ASSNNDLQVAEEQYQRLMAKVEDMQRSMLSKDNTVHDLRQQMTALQSQLQQVQLERTTLT 558
Query: 284 KELEKQQCMATELEMTVKEAKQDKSKEAECKA-LQAEVQKLK------------NSLEEA 330
+L+ Q + L+ + +Q + E + LQ E+ ++ LE
Sbjct: 559 SKLKASQAEISSLQSVRQWYQQQLALAQEARVRLQGEMAHIQVGQMTQAGLLEHLKLENV 618
Query: 331 KQQERLAAQQAAQCKEEAALAGCHLEDTQRKL--QKGLLLDKQKADTI--QELQRELQML 386
++L Q KE+ +A L+ + + Q+ + Q+A T+ ++LQR L+
Sbjct: 619 SLSQQLTETQHRSMKEKGRIA-AQLQGIEADMLDQEAAFMQIQEAKTMVEEDLQRRLEEF 677
Query: 387 QKESSMAEK---EQTSNRKRVEELSLELSEALRKLENSDKEKRQLQK--TVAEQDMKMND 441
+ E ++ S +++E++ L L + ++LE +E L K T+ ++ ++ +
Sbjct: 678 EGERERLQRMADSAASLEQQLEQVKLTLLQRDQQLEALQQEHLDLMKQLTLTQEALQSRE 737
Query: 442 M-LDRIKHQHREQGSIKCKLEEDLQEATKLLEDKREQLKKSKEHEKLMEGELEALRQEFK 500
LD ++ + E ++ +L E EA RE ++EK++ LEA Q K
Sbjct: 738 QSLDALQTHYDE---LQARLGELQGEAA-----SREDTICLLQNEKII---LEAALQAAK 786
Query: 501 KKDKTLKENSRKLEEENENLRAELQCCSTQLESSLNKYNTSQQVIQDLNKEIAL---QKE 557
+ L +R+LEE E + + ++ L +E+A+ Q E
Sbjct: 787 SGKEELDRGARRLEEGTEE---------------------TSETLEKLREELAIKSGQVE 825
Query: 558 SLMSLQAQLDKALQK-EKHYLQTTITKEAYDALSRKSAACQDDLTQALEKL-NHVTSETK 615
L A L K +QK ++ +LQ + EAY R+ A +D L L+ + SE K
Sbjct: 826 HLQQETAALKKQMQKIKEQFLQQKVMVEAY----RRDATSKDQLISELKATRKRLDSELK 881
Query: 616 SLQQSLTQTQEKKAQLEEEIIAYEERMKKLNTELRKLRGFHQESELEVHAFDKKLEEMSC 675
L+Q L Q +K E E + +L+ E+ ++R + E + + K+ +EM
Sbjct: 882 ELRQELMQVHGEKRTAEAE-------LSRLHREVAQVRQHMADLEGHLQSAQKERDEM-- 932
Query: 676 QVLQWQKQHQNDLKMLAAKEEQLREFQEEMAALKENLLEDDKEPCCLPQWSVPKDTCRLY 735
+ L+ L +EQ+ E ALK+ + E +E + ++ + ++
Sbjct: 933 ---------ETHLQSLQFDKEQMVAVTEANEALKKQIEELQQE----ARKAITEQKQKMR 979
Query: 736 R-GNDQIMTNLEQWAKQQKVANEKLGNQLREQVKYIAKLSGEKDREPTRASSPNTTRPSS 794
R G+D E K + N R Q AK + + + RA ++ S
Sbjct: 980 RLGSDLTSAQKEMKTKHKAYENAVGILSRRLQEALAAKEAADAELGQLRAQG-GSSDSSL 1038
Query: 795 PSHSHLHSVMVHLQ---QENKKLKKEIEE 820
H + ++ LQ L+KE++E
Sbjct: 1039 ALHERIQALEAELQAVSHSKTLLEKELQE 1067
Score = 79.7 bits (195), Expect = 1e-14
Identities = 123/603 (20%), Positives = 251/603 (41%), Gaps = 114/603 (18%)
Query: 6 ENTGEKLHLAQEQLALAGDKI-------ASLERSLNLYRDKYQSSLSNIEL--------- 49
E T E L +E+LA+ ++ A+L++ + ++++ +E
Sbjct: 804 EETSETLEKLREELAIKSGQVEHLQQETAALKKQMQKIKEQFLQQKVMVEAYRRDATSKD 863
Query: 50 ------------LECQVKMLQGELGGIMGQEPENKGDHSKVRIYTSPCMIQEHQETQKRL 97
L+ ++K L+ EL + G++ + + S R++ +++H +
Sbjct: 864 QLISELKATRKRLDSELKELRQELMQVHGEKRTAEAELS--RLHREVAQVRQHMADLEGH 921
Query: 98 SEVWQKVSQQDDLIQELRNKLACSNALVLEREKALIKLQADFASCTATHRYPPSSSEECE 157
+ QK ++D++ L++ L ++E+ + +A+ A + +
Sbjct: 922 LQSAQK--ERDEMETHLQS-------LQFDKEQMVAVTEANEALKKQIEELQQEARKAIT 972
Query: 158 DIKKILKHL-----QEQKDSQCLHVEEYQNLVKDLRVELEAVSEQKRNIMKDMMKLE--- 209
+ K+ ++ L QK+ + H + Y+N V L L+ K ++ +L
Sbjct: 973 EQKQKMRRLGSDLTSAQKEMKTKH-KAYENAVGILSRRLQEALAAKEAADAELGQLRAQG 1031
Query: 210 ------LDLHGLREETSAHIERKDKDITILQCRLQEL----QLEFTETQKLTLKKDKFLQ 259
L LH + A ++ T+L+ LQE+ E E+++ L+ + LQ
Sbjct: 1032 GSSDSSLALHERIQALEAELQAVSHSKTLLEKELQEVIALTSQELEESREKVLELEDELQ 1091
Query: 260 E------KDEMLQELEKKLT--------------------QVQNSLLKKEKELEKQQCMA 293
E K + L+E KKL + NS+L E L K++
Sbjct: 1092 ESRGFRKKIKRLEESNKKLALELEHEKGKLTGLGQSNAALREHNSIL--ETALAKREADL 1149
Query: 294 TELEMTVKEAKQDKSKEAE-----CKALQAEVQKLKNSLEEAKQQERLAAQQAAQCKEEA 348
+L + V+ Q K +E +ALQA ++K K + K+Q A +A +
Sbjct: 1150 VQLNLQVQAVLQRKEEEDRQMKHLVQALQASLEKEKEKVNSLKEQVAAAKVEAGHNRRHF 1209
Query: 349 ALAGCHLEDTQRKLQKGLLLDKQKADTIQELQRELQMLQKESSMAEKEQTSNRKRVEELS 408
A L + +++LQ K +Q+LQ E LQ +E + +
Sbjct: 1210 KAASLELSEVKKELQ-------AKEHLVQKLQAEADDLQIREGKHSQE-------IAQFQ 1255
Query: 409 LELSEALRKLENSDKEKRQLQKTVAEQ---DMKMNDMLDRIKHQHREQGSIKCKLEEDLQ 465
EL+EA +L+ K QL + +++Q + +M ++ + + RE S+K +L+ Q
Sbjct: 1256 AELAEARAQLQLLQK---QLDEQLSKQPVGNQEMENLKWEVDQKEREIQSLKQQLDLTEQ 1312
Query: 466 EATKLLEDKREQLKKSKEHEKLMEGELEALRQE---FKKKDKTLKENSRKLEEENENLRA 522
+ K LE ++ L+ K ++ + +L +++ + K LK N + L ++N+ L+
Sbjct: 1313 QGRKELEGLQQLLQNVKSELEMAQEDLSMTQKDKFMLQAKVSELKNNMKTLLQQNQQLKL 1372
Query: 523 ELQ 525
+L+
Sbjct: 1373 DLR 1375
Score = 60.5 bits (145), Expect = 7e-09
Identities = 104/520 (20%), Positives = 205/520 (39%), Gaps = 95/520 (18%)
Query: 240 LQLEFTETQKLTLKKDKFLQEKDEMLQELEKKLT-QVQNSLLKKEKELEKQQCMATELEM 298
L L ETQ + L++++++ + K L Q++ +K+++E Q T L
Sbjct: 126 LSLPMQETQLCSTDSPLPLEKEEQVRLQARKWLEEQLKQYRVKRQQERSSQPATKTRLFS 185
Query: 299 TVKEA---KQDKSKEAECKALQAEVQKLKNSLEEAKQQERLAA------QQAAQCKEEAA 349
T+ + A A+ E L+ S+ + L ++ ++ + +
Sbjct: 186 TLDPELMLNPENLPRASTLAMTKEYSFLRTSVPRGPKVGSLGLPAHPREKKTSKSSKIRS 245
Query: 350 LAGCHLEDTQRKLQKGLLL--DKQKADTIQELQRELQMLQKESSMAEKEQTSNRKRVEEL 407
LA ED+ G + D K Q ++ + S + + R+E
Sbjct: 246 LADYRTEDSNAGNSGGNVPAPDSTKGSLKQNRSSAASVVSEISLSPDTDD-----RLENT 300
Query: 408 SLELSEALRKLENSDKEKRQ------------LQKTVAEQDM------------------ 437
SL +++ +++ +D + L KTV QD
Sbjct: 301 SLA-GDSVSEVDGNDSDSSSYSSASTRGTYGILSKTVGTQDTPYMVNGQEIPADTLGQFP 359
Query: 438 KMNDMLDRIKHQHREQG--------SIKCKLEEDLQEATKLLEDKREQLKKSKEHEKLME 489
+ D+L +H++QG S + + + + E + E L+ KE +L E
Sbjct: 360 SIKDVLQAAAAEHQDQGQEVNGEVRSRRDSICSSVSLESSAAETQEEMLQVLKEKMRL-E 418
Query: 490 GELEALRQEFKKKDKTLKENSRKLEEENENLRAELQCCSTQLESSLNKYNTSQQVIQDLN 549
G+LEAL E S+ L+E+ E L+A+L ST+L++ + ++SQQ L+
Sbjct: 419 GQLEALS----------LEASQALKEKAE-LQAQLAALSTKLQAQVECSHSSQQRQDSLS 467
Query: 550 KEIALQKESLMSLQAQLDKALQKEKHYLQTTITKEAYDALSRKSAACQDDLTQALEKLNH 609
E+ K+S L+ + T + +A + A+ +DL A E+
Sbjct: 468 SEVDTLKQSCWDLERAM-------------TDLQNMLEAKNASLASSNNDLQVAEEQYQR 514
Query: 610 VTSETKSLQQSLTQTQEKKAQLEEEIIAYEERMKKLNTELRKLRGFHQESELEVHAFDKK 669
+ ++ + +Q+S+ L +++ A + +++++ E L + S+ E+ +
Sbjct: 515 LMAKVEDMQRSMLSKDNTVHDLRQQMTALQSQLQQVQLERTTLTSKLKASQAEISSLQ-- 572
Query: 670 LEEMSCQVLQWQKQHQNDLKMLAAKEEQLREFQEEMAALK 709
V QW +Q LA +E Q EMA ++
Sbjct: 573 ------SVRQWYQQ------QLALAQEARVRLQGEMAHIQ 600
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 118 bits (296), Expect = 2e-26
Identities = 175/892 (19%), Positives = 380/892 (42%), Gaps = 102/892 (11%)
Query: 10 EKLHLAQEQLALAGDKIASLERSLNLYRDKYQSSLSNIELLECQVKM---LQGELGGIMG 66
E++ +++L ++ E L K+ LL+ Q++ L E +
Sbjct: 852 EEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRV 911
Query: 67 QEPENKGDHSKVRIYTSPCMIQEHQETQKRLSEVWQKVSQQD-DLIQELRNKLACSNALV 125
+ K + ++ ++ ++E ++ ++L +K++QQ DL ++L + A L
Sbjct: 912 RLAAKKQELEEI-LHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQ 970
Query: 126 LER---EKALIKLQADFASCTATHRYPPSS----SEECEDIKKILKHLQEQKDSQCLHVE 178
LE+ E + KL+ + + E D+ L +E+ +
Sbjct: 971 LEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKN 1030
Query: 179 EYQNLVKDLRVELEAVSEQKRNIMKDMMKLELDLHGLREETSAHIERKDKDITILQCRLQ 238
++++++ +L V L+ + ++ + K KLE D E+ I LQ ++
Sbjct: 1031 KHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQ-----------IADLQAQIA 1079
Query: 239 ELQLEFT----ETQKLTLKKDKFLQEKDEMLQ---ELEKKLTQVQ----------NSLLK 281
EL+++ E Q + D + +K+ L+ ELE ++ +Q N K
Sbjct: 1080 ELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEK 1139
Query: 282 KEKEL-EKQQCMATELEMTVKE--------AKQDKSKEAECKALQAEVQKLKNSLEEAKQ 332
++++L E+ + + TELE T+ AK+++ KAL E + + ++E +Q
Sbjct: 1140 QKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQ 1199
Query: 333 QERLAAQQAAQCKEEAALAGCHLEDTQRKLQKG----------LLLDKQKAD-TIQELQR 381
+ A ++ + E+ A +L+ ++ L+K L KQ+ + ++L+
Sbjct: 1200 KHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEA 1259
Query: 382 ELQMLQKESSMAEKEQTSNRKRVEELSLELSEALRKLENSDKEKRQLQKTVAEQDMKMND 441
++Q LQ + S E+ + +V +L E+ L ++ + +L K VA ++ D
Sbjct: 1260 QVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQD 1319
Query: 442 MLDRIKHQHREQGSIKCKLEEDLQEATKLLEDKREQLKKSKEHEKLMEGELEALRQEFKK 501
+ ++ + R++ ++ KL + L+E L+D+ ++ ++K++ + L + KK
Sbjct: 1320 TQELLQEETRQKLNVSTKLRQ-LEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKK 1378
Query: 502 KDKTLKENSRKLEEENENLRAELQCCSTQLESSLNKY-------NTSQQVIQDLNKEIAL 554
K + LEE + + E++ + Q E Y N QQ + DL ++
Sbjct: 1379 KLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDN 1438
Query: 555 QKESLMSL---QAQLDKALQKEKHYLQTTITKEAYDALSRKSAACQDDLTQALEKLNHVT 611
Q++ + +L Q + D+ L +EK+ I+ + D R A ++ T+AL L
Sbjct: 1439 QRQLVSNLEKKQRKFDQLLAEEKN-----ISSKYADERDRAEAEAREKETKALS-LARAL 1492
Query: 612 SETKSLQQSLTQTQEK-KAQLEEEIIA----------YEERMKKLNTELRKLRGFHQESE 660
E ++ L +T + KA++E+ + + E+ + L T++ +++ +E E
Sbjct: 1493 EEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELE 1552
Query: 661 LEVHAFDKKLEEMSCQVLQWQKQHQNDLKMLAAKEEQLREFQEEMAALKENLLEDDKEPC 720
E+ A + + + + Q + DL+ + E+ R + E LED+++
Sbjct: 1553 DELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQR 1612
Query: 721 CLPQWSVPKDTCRLYRGNDQIMTNLEQWAKQQKVANEKLGNQLREQVKYIAKLSGE-KDR 779
L + K G+ + +LE A E+ QLR+ + E +D
Sbjct: 1613 ALAAAAKKK-----LEGD---LKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDA 1664
Query: 780 EPTRASSPNTTRPSSPSHSHLHSVMVHLQQ-----ENKKLKKEIEEKKMKAE 826
+R T + + L + ++ LQ+ E + + ++E++++ E
Sbjct: 1665 RASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEE 1716
Score = 117 bits (292), Expect = 6e-26
Identities = 170/953 (17%), Positives = 415/953 (43%), Gaps = 127/953 (13%)
Query: 1 MGNHNENTGEKLHLAQEQLALAGDKIASLE---RSLNLYRDKYQSSLSNIEL-------- 49
M + N ++ L +E+++ +A E ++L ++K++S +S +E+
Sbjct: 990 MDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKS 1049
Query: 50 ---LECQVKMLQGELGGIMGQEPENKGDHSKVRIYTSPCMIQEHQETQKRLSEVWQKVSQ 106
LE + L+G+ Q + + +++++ + ++ +E Q L+ + +++Q
Sbjct: 1050 RQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQ----LAKKEEELQAALARLDDEIAQ 1105
Query: 107 QD--------------DLIQELRNKLACSNALVLEREKALIKLQA------DFASCTATH 146
++ DL ++L ++ A N ++ +L+A D TAT
Sbjct: 1106 KNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQ 1165
Query: 147 RYPPSSSEECEDIKKILKHLQEQKDSQCLHVEE----YQNLVKDLRVELEAVSEQKRNIM 202
+ + E+ ++ + K L E+ S V+E + V++L +LE K N+
Sbjct: 1166 QELRAKREQ--EVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLD 1223
Query: 203 KDMMKLE---LDLHG---LREETSAHIERKDKDITILQCRLQELQLEFTETQKLTLKKDK 256
K+ LE DL G + + +E K K L+ ++QELQ + ++ ++ + +
Sbjct: 1224 KNKQTLEKENADLAGELRVLGQAKQEVEHKKKK---LEAQVQELQSKCSDGERARAELND 1280
Query: 257 FLQEKDEMLQELEKKLTQVQNSLLKKEKELEKQQCMATELEMTVKEAKQDKSKEAECKAL 316
+ + ++ + L + + +K K++ ++++L+ T + +++ ++
Sbjct: 1281 KVHKLQNEVESVTGMLNEAEGKAIKLAKDVAS---LSSQLQDTQELLQEETRQKLNVSTK 1337
Query: 317 QAEVQKLKNSLEEAKQQERLAAQQAAQCKEEAALAGCHLEDTQRKLQKGLLLDKQKADTI 376
++++ +NSL++ +E A Q + + L D+++KLQ + +
Sbjct: 1338 LRQLEEERNSLQDQLDEEMEAKQNL---ERHISTLNIQLSDSKKKLQDFASTVEALEEGK 1394
Query: 377 QELQRELQML-----QKESSMAEKEQTSNR--KRVEELSLELSEALRKLENSDKEKRQLQ 429
+ Q+E++ L +K ++ + E+T NR + +++L ++L + + N +K++R+
Sbjct: 1395 KRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFD 1454
Query: 430 KTVAEQ---DMKMNDMLDRIKHQHREQGSIKCKLEEDLQEATKLLEDKREQLKKSKEHEK 486
+ +AE+ K D DR + + RE+ + L L+EA + +E+L+++ + K
Sbjct: 1455 QLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEAL----EAKEELERTNKMLK 1510
Query: 487 LMEGELEALRQEFKKKDKTLKENSRKLEEENENLRAELQCCSTQLESSLNKYNTSQQVIQ 546
+L + + + K L+++ R LE + E ++ +L+ +L+++ + + +Q
Sbjct: 1511 AEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQ 1570
Query: 547 DLNKEIALQKESLMSLQAQLDKALQKEKHYLQTTITKEAYD-----ALSRKSAACQDDLT 601
L + ++ + + LQ++ H +T + E A +K DL
Sbjct: 1571 ALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLE 1630
Query: 602 -----------QALEKLNHVTSETKSLQQSLTQTQEKKAQLEEEIIAYEERMKKLNTELR 650
+A+++L + ++ K Q+ L + + ++ E++ K L +L
Sbjct: 1631 LQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLM 1690
Query: 651 KLRGFHQESELEVHAFDKKLEEMSCQV---LQWQKQHQNDLKMLAAK----EEQLREFQE 703
+L+ +E D + EE++ ++ L + Q++ + L A+ EE+L E Q
Sbjct: 1691 QLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQG 1750
Query: 704 EMAALKENLLEDDKEPCCLP-QWSVPKDTCRLYRGNDQIMTNLEQWAKQQKVANEKLGNQ 762
M A+ + + + ++ L + + + T + N+ LE+ K+ + ++
Sbjct: 1751 NMEAMSDRVRKATQQAEQLSNELATERSTAQK---NESARQQLERQNKELRSKLHEMEGA 1807
Query: 763 LREQVKY--------IAKLSGEKDREPTRASSPNTTRPSSPSHSHLHSVMVHLQQENK-- 812
++ + K IA+L + ++E + T+ L +++ ++ E K
Sbjct: 1808 VKSKFKSTIAALEAKIAQLEEQVEQEAREKQA--ATKSLKQKDKKLKEILLQVEDERKMA 1865
Query: 813 ---------------KLKKEIEEKKMKAENTRLCTKALGPSRTESTQREKVCG 850
+LK+++EE + +++ + L E+T+ + G
Sbjct: 1866 EQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMG 1918
Score = 112 bits (279), Expect = 2e-24
Identities = 192/892 (21%), Positives = 369/892 (41%), Gaps = 117/892 (13%)
Query: 17 EQLALAGDKIASLERSLNLYRDKYQSSLSNIELLECQVKMLQGELGGIMGQEPENKGDHS 76
EQ+A +IA L+ L ++ Q++L+ ++ Q ++ + G + + D
Sbjct: 1069 EQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLD 1128
Query: 77 KVRIYTSPCMIQEHQETQKRLSEVWQKVSQQDDLIQELRNKLACSNALVLEREKALIKLQ 136
R + E QKR ++ +++ +++ + A L +RE+ + L+
Sbjct: 1129 SERA------ARNKAEKQKR--DLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLK 1180
Query: 137 ADFASCTATH--RYPPSSSEECEDIKKILKHLQEQKDSQCLHVEEYQNLVK---DLRVEL 191
T +H + + + ++++ + L++ K ++ + Q L K DL EL
Sbjct: 1181 KALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGEL 1240
Query: 192 EAVSEQKRNIMKDMMKLELDLHGLREETS----AHIERKDKDITILQCRLQEL--QLEFT 245
+ + K+ + KLE + L+ + S A E DK + LQ ++ + L
Sbjct: 1241 RVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDK-VHKLQNEVESVTGMLNEA 1299
Query: 246 ETQKLTLKKD-----KFLQEKDEMLQELEKKLTQVQNSLLKKEKELEKQQCMATELEMTV 300
E + + L KD LQ+ E+LQE ++ V L + E+E Q E EM
Sbjct: 1300 EGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDE-EM-- 1356
Query: 301 KEAKQDKSKEAECKALQAEVQKLK--------NSLEEAKQQERLAAQQAAQCKEEAALAG 352
EAKQ+ + +Q K K +LEE K++ + + Q EE A A
Sbjct: 1357 -EAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAY 1415
Query: 353 CHLEDTQRKLQK---GLLLD----KQKADTIQELQRELQMLQKESSMAEKEQTSNRKRVE 405
LE T+ +LQ+ L++D +Q +++ QR+ L E + R R E
Sbjct: 1416 DKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAE 1475
Query: 406 ----ELSLELSEALRKLENSDKEKRQLQKTVAEQDMKMNDML---DRIKHQHREQGSIKC 458
E + R LE + + K +L++T +M D++ D + E K
Sbjct: 1476 AEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKR 1535
Query: 459 KLEEDLQEATKLLEDKREQLKKSKEHEKLMEGELEALRQEFKKKDKTLKENSRKLEEENE 518
LE ++E LE+ ++L+ +++ + +E ++AL+ +F ++ L+ + EE+
Sbjct: 1536 ALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQF---ERDLQARDEQNEEKRR 1592
Query: 519 NLRAELQCCSTQLESSLNKYNTSQQVIQDLN---KEIALQKES-----------LMSLQA 564
L+ +L T+LE + + + L K++ LQ +S L LQA
Sbjct: 1593 QLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQA 1652
Query: 565 QLD--------------------KALQKEKHYLQTTITKEAYDALSRKSAACQDDLT--Q 602
Q+ K +K+ L+ + + D + + A Q DL +
Sbjct: 1653 QMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEE 1712
Query: 603 ALEKLNHVTSETKSLQQSLTQTQEKKAQLEEEIIAYEERMKKLNTELRKLRGFHQESELE 662
E+L S +LQ + + + AQLEEE+ + M+ ++ +RK Q +L
Sbjct: 1713 LAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRK--ATQQAEQLS 1770
Query: 663 VHAFDKKLEEMSCQVLQWQKQHQNDLKMLAAKEEQLR-----EFQEEMAALKENL--LED 715
++ + + Q + QN K L +K ++ +F+ +AAL+ + LE+
Sbjct: 1771 NELATERSTAQKNESARQQLERQN--KELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEE 1828
Query: 716 DKEPCCLPQWSVPKDTCRLYRGNDQIMTNLE---QWAKQQKVANEKLGNQLREQVKYIAK 772
E + + K + + +I+ +E + A+Q K EK GN +VK + +
Sbjct: 1829 QVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEK-GN---ARVKQLKR 1884
Query: 773 LSGEKDREPTRASSPNTTRPSSPSHSHLHSVMVHLQQENKKLKKEIEEKKMK 824
E + E R ++ + L + + N+ + +E+ K K
Sbjct: 1885 QLEEAEEESQRINA---------NRRKLQRELDEATESNEAMGREVNALKSK 1927
Score = 106 bits (265), Expect = 8e-23
Identities = 136/640 (21%), Positives = 268/640 (41%), Gaps = 92/640 (14%)
Query: 26 IASLERSLNLYRDKYQSSLSNIELLECQVKMLQGELGGIMGQEPENKGDHSKVRIYTSPC 85
I++L L+ + K Q S +E LE K Q E+ + Q E + K+
Sbjct: 1366 ISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKL------- 1418
Query: 86 MIQEHQETQKRLSEVWQKVSQQDDLIQELRNKLACSNALVLEREK--ALIKLQADFASCT 143
++T+ RL + + DDL+ +L N+ + L ++ K L+ + + +S
Sbjct: 1419 -----EKTKNRLQQ------ELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKY 1467
Query: 144 ATHRYPPSSSEECEDIK--KILKHLQEQKDSQCLHVEEYQNLVKDLRVELEAVSEQKRNI 201
A R + ++ K + + L+E +++ EE + K L+ E+E + K ++
Sbjct: 1468 ADERDRAEAEAREKETKALSLARALEEALEAK----EELERTNKMLKAEMEDLVSSKDDV 1523
Query: 202 MKDMMKLELDLHGLR---EETSAHIERKDKDITILQCRLQELQLEFTETQKLTLKKDKFL 258
K++ +LE L EE +E + ++ + L++ Q L + ++ L
Sbjct: 1524 GKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNM---QALKGQFERDL 1580
Query: 259 QEKDEMLQELEKKLTQVQNSLLKKEKELE---KQQCMATELEMTVKEAKQDKSKEAECKA 315
Q +DE + E+K Q+Q L + E ELE KQ+ +A A K E + K
Sbjct: 1581 QARDE---QNEEKRRQLQRQLHEYETELEDERKQRALA---------AAAKKKLEGDLKD 1628
Query: 316 LQAEVQKLKNSLEEAKQQERLAAQQAAQCKEEAALAGCHLEDTQRKLQKGLLLDKQKADT 375
L+ + EEA +Q R Q + E LED + + K+
Sbjct: 1629 LELQADSAIKGREEAIKQLRKLQAQMKDFQRE-------LEDARASRDEIFATAKENEKK 1681
Query: 376 IQELQRELQMLQKESSMAEKEQTSNRKRVEELSLELSEALRKLENSDKEKRQLQKTVAEQ 435
+ L+ +L LQ++ + AE+ + EEL+ EL+ +L EKR+L+ +A+
Sbjct: 1682 AKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQ- 1740
Query: 436 DMKMNDMLDRIKHQHREQGSIKCKLEEDLQEATKLLEDKREQLKKSKEHEKLMEGELEAL 495
LEE+L+E +E ++++K+ + + + EL
Sbjct: 1741 ------------------------LEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATE 1776
Query: 496 RQEFKKKDKTLKENSRKLEEENENLRAELQ----CCSTQLESSLNKYNTSQQVIQDLNKE 551
R +K + ++LE +N+ LR++L ++ +S++ +++ ++
Sbjct: 1777 RSTAQKNESA----RQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQ 1832
Query: 552 IALQKESLMSLQAQLDK-----ALQKEKHYLQTTITKEAYDALSRKSAACQDDLTQALEK 606
A +K++ Q DK LQ E KE + + + + L +A E+
Sbjct: 1833 EAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEE 1892
Query: 607 LNHVTSETKSLQQSLTQTQEKKAQLEEEIIAYEERMKKLN 646
+ + + LQ+ L + E + E+ A + ++++ N
Sbjct: 1893 SQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGN 1932
Score = 100 bits (249), Expect = 6e-21
Identities = 140/661 (21%), Positives = 277/661 (41%), Gaps = 115/661 (17%)
Query: 279 LLKKEKELEKQQCMATELEMTVKEAKQDKSKEAECKALQAEVQKLKNSLEEAKQQERLAA 338
LL+ ++ E+ Q EL+ T + ++ +++ E + +++ + KN L+E Q E
Sbjct: 844 LLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELY 903
Query: 339 QQAAQCKEEAALAGCHLEDTQRKLQKGLLLDKQKADTIQELQREL--QMLQKESSMAEKE 396
+A + + A LE+ +++ L ++ + +Q ++++ QML E + E+E
Sbjct: 904 AEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEE 963
Query: 397 QTSNRKRVEELSLELSEALRKLENS-----------DKEKRQLQKTV-------AEQDMK 438
+ ++E+++ E ++KLE+ KE++ L++ + AE++ K
Sbjct: 964 AARQKLQLEKVTAEAK--IKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEK 1021
Query: 439 MNDMLDRIKHQH------------------REQGSIKCKLEEDLQEATKLLEDKREQLKK 480
+ L ++K++H +E +K KLE D + + + D + Q+ +
Sbjct: 1022 AKN-LTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAE 1080
Query: 481 SKEHEKLMEGELEA----LRQEFKKKDKTLKE--------------------NSRKLEEE 516
K E EL+A L E +K+ LK+ K E++
Sbjct: 1081 LKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQ 1140
Query: 517 NENLRAELQCCSTQLESSLNKYNTSQQVIQDLNKEIALQKESL----MSLQAQLDKALQK 572
+L EL+ T+LE +L+ T Q++ +E+ + K++L S +AQ+ + +
Sbjct: 1141 KRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQE--MR 1198
Query: 573 EKHYLQTTITKEAYDALSRKSAACQDDLTQALEKLN-HVTSETKSLQQSLTQTQEKKAQL 631
+KH E + R A D Q LEK N + E + L Q+ + + KK +L
Sbjct: 1199 QKHAQAVEELTEQLEQFKRAKANL-DKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKL 1257
Query: 632 EEEI--------------IAYEERMKKLNTELRKLRGFHQESELEVHAFDKKLEEMSCQV 677
E ++ +++ KL E+ + G E+E + K + +S Q+
Sbjct: 1258 EAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQL 1317
Query: 678 LQWQKQHQNDLKMLAAKEEQLREFQEEMAALKENLLEDDKEPCCLPQWSVP-----KDTC 732
Q+ Q + + +LR+ +EE +L++ L E+ + L + D+
Sbjct: 1318 QDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSK 1377
Query: 733 RLYRGNDQIMTNLEQWAKQQKVANEKLGNQLREQVKYIAKLSGEKDREPTRASSPNTTRP 792
+ + + LE+ K+ + E L Q E+ KL K+R
Sbjct: 1378 KKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNR------------- 1424
Query: 793 SSPSHSHLHSVMVHLQQENKKLKKEIEEKKMK-----AENTRLCTK-ALGPSRTESTQRE 846
L ++V L + ++L +E+K+ K AE + +K A R E+ RE
Sbjct: 1425 ---LQQELDDLVVDLDNQ-RQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEARE 1480
Query: 847 K 847
K
Sbjct: 1481 K 1481
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 118 bits (296), Expect = 2e-26
Identities = 175/892 (19%), Positives = 380/892 (42%), Gaps = 102/892 (11%)
Query: 10 EKLHLAQEQLALAGDKIASLERSLNLYRDKYQSSLSNIELLECQVKM---LQGELGGIMG 66
E++ +++L ++ E L K+ LL+ Q++ L E +
Sbjct: 859 EEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRV 918
Query: 67 QEPENKGDHSKVRIYTSPCMIQEHQETQKRLSEVWQKVSQQD-DLIQELRNKLACSNALV 125
+ K + ++ ++ ++E ++ ++L +K++QQ DL ++L + A L
Sbjct: 919 RLAAKKQELEEI-LHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQ 977
Query: 126 LER---EKALIKLQADFASCTATHRYPPSS----SEECEDIKKILKHLQEQKDSQCLHVE 178
LE+ E + KL+ + + E D+ L +E+ +
Sbjct: 978 LEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKN 1037
Query: 179 EYQNLVKDLRVELEAVSEQKRNIMKDMMKLELDLHGLREETSAHIERKDKDITILQCRLQ 238
++++++ +L V L+ + ++ + K KLE D E+ I LQ ++
Sbjct: 1038 KHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQ-----------IADLQAQIA 1086
Query: 239 ELQLEFT----ETQKLTLKKDKFLQEKDEMLQ---ELEKKLTQVQ----------NSLLK 281
EL+++ E Q + D + +K+ L+ ELE ++ +Q N K
Sbjct: 1087 ELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEK 1146
Query: 282 KEKEL-EKQQCMATELEMTVKE--------AKQDKSKEAECKALQAEVQKLKNSLEEAKQ 332
++++L E+ + + TELE T+ AK+++ KAL E + + ++E +Q
Sbjct: 1147 QKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQ 1206
Query: 333 QERLAAQQAAQCKEEAALAGCHLEDTQRKLQKG----------LLLDKQKAD-TIQELQR 381
+ A ++ + E+ A +L+ ++ L+K L KQ+ + ++L+
Sbjct: 1207 KHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEA 1266
Query: 382 ELQMLQKESSMAEKEQTSNRKRVEELSLELSEALRKLENSDKEKRQLQKTVAEQDMKMND 441
++Q LQ + S E+ + +V +L E+ L ++ + +L K VA ++ D
Sbjct: 1267 QVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQD 1326
Query: 442 MLDRIKHQHREQGSIKCKLEEDLQEATKLLEDKREQLKKSKEHEKLMEGELEALRQEFKK 501
+ ++ + R++ ++ KL + L+E L+D+ ++ ++K++ + L + KK
Sbjct: 1327 TQELLQEETRQKLNVSTKLRQ-LEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKK 1385
Query: 502 KDKTLKENSRKLEEENENLRAELQCCSTQLESSLNKY-------NTSQQVIQDLNKEIAL 554
K + LEE + + E++ + Q E Y N QQ + DL ++
Sbjct: 1386 KLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDN 1445
Query: 555 QKESLMSL---QAQLDKALQKEKHYLQTTITKEAYDALSRKSAACQDDLTQALEKLNHVT 611
Q++ + +L Q + D+ L +EK+ I+ + D R A ++ T+AL L
Sbjct: 1446 QRQLVSNLEKKQRKFDQLLAEEKN-----ISSKYADERDRAEAEAREKETKALS-LARAL 1499
Query: 612 SETKSLQQSLTQTQEK-KAQLEEEIIA----------YEERMKKLNTELRKLRGFHQESE 660
E ++ L +T + KA++E+ + + E+ + L T++ +++ +E E
Sbjct: 1500 EEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELE 1559
Query: 661 LEVHAFDKKLEEMSCQVLQWQKQHQNDLKMLAAKEEQLREFQEEMAALKENLLEDDKEPC 720
E+ A + + + + Q + DL+ + E+ R + E LED+++
Sbjct: 1560 DELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQR 1619
Query: 721 CLPQWSVPKDTCRLYRGNDQIMTNLEQWAKQQKVANEKLGNQLREQVKYIAKLSGE-KDR 779
L + K G+ + +LE A E+ QLR+ + E +D
Sbjct: 1620 ALAAAAKKK-----LEGD---LKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDA 1671
Query: 780 EPTRASSPNTTRPSSPSHSHLHSVMVHLQQ-----ENKKLKKEIEEKKMKAE 826
+R T + + L + ++ LQ+ E + + ++E++++ E
Sbjct: 1672 RASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEE 1723
Score = 117 bits (292), Expect = 6e-26
Identities = 170/953 (17%), Positives = 415/953 (43%), Gaps = 127/953 (13%)
Query: 1 MGNHNENTGEKLHLAQEQLALAGDKIASLE---RSLNLYRDKYQSSLSNIEL-------- 49
M + N ++ L +E+++ +A E ++L ++K++S +S +E+
Sbjct: 997 MDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKS 1056
Query: 50 ---LECQVKMLQGELGGIMGQEPENKGDHSKVRIYTSPCMIQEHQETQKRLSEVWQKVSQ 106
LE + L+G+ Q + + +++++ + ++ +E Q L+ + +++Q
Sbjct: 1057 RQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQ----LAKKEEELQAALARLDDEIAQ 1112
Query: 107 QD--------------DLIQELRNKLACSNALVLEREKALIKLQA------DFASCTATH 146
++ DL ++L ++ A N ++ +L+A D TAT
Sbjct: 1113 KNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQ 1172
Query: 147 RYPPSSSEECEDIKKILKHLQEQKDSQCLHVEE----YQNLVKDLRVELEAVSEQKRNIM 202
+ + E+ ++ + K L E+ S V+E + V++L +LE K N+
Sbjct: 1173 QELRAKREQ--EVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLD 1230
Query: 203 KDMMKLE---LDLHG---LREETSAHIERKDKDITILQCRLQELQLEFTETQKLTLKKDK 256
K+ LE DL G + + +E K K L+ ++QELQ + ++ ++ + +
Sbjct: 1231 KNKQTLEKENADLAGELRVLGQAKQEVEHKKKK---LEAQVQELQSKCSDGERARAELND 1287
Query: 257 FLQEKDEMLQELEKKLTQVQNSLLKKEKELEKQQCMATELEMTVKEAKQDKSKEAECKAL 316
+ + ++ + L + + +K K++ ++++L+ T + +++ ++
Sbjct: 1288 KVHKLQNEVESVTGMLNEAEGKAIKLAKDVAS---LSSQLQDTQELLQEETRQKLNVSTK 1344
Query: 317 QAEVQKLKNSLEEAKQQERLAAQQAAQCKEEAALAGCHLEDTQRKLQKGLLLDKQKADTI 376
++++ +NSL++ +E A Q + + L D+++KLQ + +
Sbjct: 1345 LRQLEEERNSLQDQLDEEMEAKQNL---ERHISTLNIQLSDSKKKLQDFASTVEALEEGK 1401
Query: 377 QELQRELQML-----QKESSMAEKEQTSNR--KRVEELSLELSEALRKLENSDKEKRQLQ 429
+ Q+E++ L +K ++ + E+T NR + +++L ++L + + N +K++R+
Sbjct: 1402 KRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFD 1461
Query: 430 KTVAEQ---DMKMNDMLDRIKHQHREQGSIKCKLEEDLQEATKLLEDKREQLKKSKEHEK 486
+ +AE+ K D DR + + RE+ + L L+EA + +E+L+++ + K
Sbjct: 1462 QLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEAL----EAKEELERTNKMLK 1517
Query: 487 LMEGELEALRQEFKKKDKTLKENSRKLEEENENLRAELQCCSTQLESSLNKYNTSQQVIQ 546
+L + + + K L+++ R LE + E ++ +L+ +L+++ + + +Q
Sbjct: 1518 AEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQ 1577
Query: 547 DLNKEIALQKESLMSLQAQLDKALQKEKHYLQTTITKEAYD-----ALSRKSAACQDDLT 601
L + ++ + + LQ++ H +T + E A +K DL
Sbjct: 1578 ALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLE 1637
Query: 602 -----------QALEKLNHVTSETKSLQQSLTQTQEKKAQLEEEIIAYEERMKKLNTELR 650
+A+++L + ++ K Q+ L + + ++ E++ K L +L
Sbjct: 1638 LQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLM 1697
Query: 651 KLRGFHQESELEVHAFDKKLEEMSCQV---LQWQKQHQNDLKMLAAK----EEQLREFQE 703
+L+ +E D + EE++ ++ L + Q++ + L A+ EE+L E Q
Sbjct: 1698 QLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQG 1757
Query: 704 EMAALKENLLEDDKEPCCLP-QWSVPKDTCRLYRGNDQIMTNLEQWAKQQKVANEKLGNQ 762
M A+ + + + ++ L + + + T + N+ LE+ K+ + ++
Sbjct: 1758 NMEAMSDRVRKATQQAEQLSNELATERSTAQK---NESARQQLERQNKELRSKLHEMEGA 1814
Query: 763 LREQVKY--------IAKLSGEKDREPTRASSPNTTRPSSPSHSHLHSVMVHLQQENK-- 812
++ + K IA+L + ++E + T+ L +++ ++ E K
Sbjct: 1815 VKSKFKSTIAALEAKIAQLEEQVEQEAREKQA--ATKSLKQKDKKLKEILLQVEDERKMA 1872
Query: 813 ---------------KLKKEIEEKKMKAENTRLCTKALGPSRTESTQREKVCG 850
+LK+++EE + +++ + L E+T+ + G
Sbjct: 1873 EQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMG 1925
Score = 112 bits (279), Expect = 2e-24
Identities = 192/892 (21%), Positives = 369/892 (41%), Gaps = 117/892 (13%)
Query: 17 EQLALAGDKIASLERSLNLYRDKYQSSLSNIELLECQVKMLQGELGGIMGQEPENKGDHS 76
EQ+A +IA L+ L ++ Q++L+ ++ Q ++ + G + + D
Sbjct: 1076 EQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLD 1135
Query: 77 KVRIYTSPCMIQEHQETQKRLSEVWQKVSQQDDLIQELRNKLACSNALVLEREKALIKLQ 136
R + E QKR ++ +++ +++ + A L +RE+ + L+
Sbjct: 1136 SERA------ARNKAEKQKR--DLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLK 1187
Query: 137 ADFASCTATH--RYPPSSSEECEDIKKILKHLQEQKDSQCLHVEEYQNLVK---DLRVEL 191
T +H + + + ++++ + L++ K ++ + Q L K DL EL
Sbjct: 1188 KALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGEL 1247
Query: 192 EAVSEQKRNIMKDMMKLELDLHGLREETS----AHIERKDKDITILQCRLQEL--QLEFT 245
+ + K+ + KLE + L+ + S A E DK + LQ ++ + L
Sbjct: 1248 RVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDK-VHKLQNEVESVTGMLNEA 1306
Query: 246 ETQKLTLKKD-----KFLQEKDEMLQELEKKLTQVQNSLLKKEKELEKQQCMATELEMTV 300
E + + L KD LQ+ E+LQE ++ V L + E+E Q E EM
Sbjct: 1307 EGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDE-EM-- 1363
Query: 301 KEAKQDKSKEAECKALQAEVQKLK--------NSLEEAKQQERLAAQQAAQCKEEAALAG 352
EAKQ+ + +Q K K +LEE K++ + + Q EE A A
Sbjct: 1364 -EAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAY 1422
Query: 353 CHLEDTQRKLQK---GLLLD----KQKADTIQELQRELQMLQKESSMAEKEQTSNRKRVE 405
LE T+ +LQ+ L++D +Q +++ QR+ L E + R R E
Sbjct: 1423 DKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAE 1482
Query: 406 ----ELSLELSEALRKLENSDKEKRQLQKTVAEQDMKMNDML---DRIKHQHREQGSIKC 458
E + R LE + + K +L++T +M D++ D + E K
Sbjct: 1483 AEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKR 1542
Query: 459 KLEEDLQEATKLLEDKREQLKKSKEHEKLMEGELEALRQEFKKKDKTLKENSRKLEEENE 518
LE ++E LE+ ++L+ +++ + +E ++AL+ +F ++ L+ + EE+
Sbjct: 1543 ALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQF---ERDLQARDEQNEEKRR 1599
Query: 519 NLRAELQCCSTQLESSLNKYNTSQQVIQDLN---KEIALQKES-----------LMSLQA 564
L+ +L T+LE + + + L K++ LQ +S L LQA
Sbjct: 1600 QLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQA 1659
Query: 565 QLD--------------------KALQKEKHYLQTTITKEAYDALSRKSAACQDDLT--Q 602
Q+ K +K+ L+ + + D + + A Q DL +
Sbjct: 1660 QMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEE 1719
Query: 603 ALEKLNHVTSETKSLQQSLTQTQEKKAQLEEEIIAYEERMKKLNTELRKLRGFHQESELE 662
E+L S +LQ + + + AQLEEE+ + M+ ++ +RK Q +L
Sbjct: 1720 LAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRK--ATQQAEQLS 1777
Query: 663 VHAFDKKLEEMSCQVLQWQKQHQNDLKMLAAKEEQLR-----EFQEEMAALKENL--LED 715
++ + + Q + QN K L +K ++ +F+ +AAL+ + LE+
Sbjct: 1778 NELATERSTAQKNESARQQLERQN--KELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEE 1835
Query: 716 DKEPCCLPQWSVPKDTCRLYRGNDQIMTNLE---QWAKQQKVANEKLGNQLREQVKYIAK 772
E + + K + + +I+ +E + A+Q K EK GN +VK + +
Sbjct: 1836 QVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEK-GN---ARVKQLKR 1891
Query: 773 LSGEKDREPTRASSPNTTRPSSPSHSHLHSVMVHLQQENKKLKKEIEEKKMK 824
E + E R ++ + L + + N+ + +E+ K K
Sbjct: 1892 QLEEAEEESQRINA---------NRRKLQRELDEATESNEAMGREVNALKSK 1934
Score = 106 bits (265), Expect = 8e-23
Identities = 136/640 (21%), Positives = 268/640 (41%), Gaps = 92/640 (14%)
Query: 26 IASLERSLNLYRDKYQSSLSNIELLECQVKMLQGELGGIMGQEPENKGDHSKVRIYTSPC 85
I++L L+ + K Q S +E LE K Q E+ + Q E + K+
Sbjct: 1373 ISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKL------- 1425
Query: 86 MIQEHQETQKRLSEVWQKVSQQDDLIQELRNKLACSNALVLEREK--ALIKLQADFASCT 143
++T+ RL + + DDL+ +L N+ + L ++ K L+ + + +S
Sbjct: 1426 -----EKTKNRLQQ------ELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKY 1474
Query: 144 ATHRYPPSSSEECEDIK--KILKHLQEQKDSQCLHVEEYQNLVKDLRVELEAVSEQKRNI 201
A R + ++ K + + L+E +++ EE + K L+ E+E + K ++
Sbjct: 1475 ADERDRAEAEAREKETKALSLARALEEALEAK----EELERTNKMLKAEMEDLVSSKDDV 1530
Query: 202 MKDMMKLELDLHGLR---EETSAHIERKDKDITILQCRLQELQLEFTETQKLTLKKDKFL 258
K++ +LE L EE +E + ++ + L++ Q L + ++ L
Sbjct: 1531 GKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNM---QALKGQFERDL 1587
Query: 259 QEKDEMLQELEKKLTQVQNSLLKKEKELE---KQQCMATELEMTVKEAKQDKSKEAECKA 315
Q +DE + E+K Q+Q L + E ELE KQ+ +A A K E + K
Sbjct: 1588 QARDE---QNEEKRRQLQRQLHEYETELEDERKQRALA---------AAAKKKLEGDLKD 1635
Query: 316 LQAEVQKLKNSLEEAKQQERLAAQQAAQCKEEAALAGCHLEDTQRKLQKGLLLDKQKADT 375
L+ + EEA +Q R Q + E LED + + K+
Sbjct: 1636 LELQADSAIKGREEAIKQLRKLQAQMKDFQRE-------LEDARASRDEIFATAKENEKK 1688
Query: 376 IQELQRELQMLQKESSMAEKEQTSNRKRVEELSLELSEALRKLENSDKEKRQLQKTVAEQ 435
+ L+ +L LQ++ + AE+ + EEL+ EL+ +L EKR+L+ +A+
Sbjct: 1689 AKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQ- 1747
Query: 436 DMKMNDMLDRIKHQHREQGSIKCKLEEDLQEATKLLEDKREQLKKSKEHEKLMEGELEAL 495
LEE+L+E +E ++++K+ + + + EL
Sbjct: 1748 ------------------------LEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATE 1783
Query: 496 RQEFKKKDKTLKENSRKLEEENENLRAELQ----CCSTQLESSLNKYNTSQQVIQDLNKE 551
R +K + ++LE +N+ LR++L ++ +S++ +++ ++
Sbjct: 1784 RSTAQKNESA----RQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQ 1839
Query: 552 IALQKESLMSLQAQLDK-----ALQKEKHYLQTTITKEAYDALSRKSAACQDDLTQALEK 606
A +K++ Q DK LQ E KE + + + + L +A E+
Sbjct: 1840 EAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEE 1899
Query: 607 LNHVTSETKSLQQSLTQTQEKKAQLEEEIIAYEERMKKLN 646
+ + + LQ+ L + E + E+ A + ++++ N
Sbjct: 1900 SQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGN 1939
Score = 100 bits (249), Expect = 6e-21
Identities = 140/661 (21%), Positives = 277/661 (41%), Gaps = 115/661 (17%)
Query: 279 LLKKEKELEKQQCMATELEMTVKEAKQDKSKEAECKALQAEVQKLKNSLEEAKQQERLAA 338
LL+ ++ E+ Q EL+ T + ++ +++ E + +++ + KN L+E Q E
Sbjct: 851 LLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELY 910
Query: 339 QQAAQCKEEAALAGCHLEDTQRKLQKGLLLDKQKADTIQELQREL--QMLQKESSMAEKE 396
+A + + A LE+ +++ L ++ + +Q ++++ QML E + E+E
Sbjct: 911 AEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEE 970
Query: 397 QTSNRKRVEELSLELSEALRKLENS-----------DKEKRQLQKTV-------AEQDMK 438
+ ++E+++ E ++KLE+ KE++ L++ + AE++ K
Sbjct: 971 AARQKLQLEKVTAEAK--IKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEK 1028
Query: 439 MNDMLDRIKHQH------------------REQGSIKCKLEEDLQEATKLLEDKREQLKK 480
+ L ++K++H +E +K KLE D + + + D + Q+ +
Sbjct: 1029 AKN-LTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAE 1087
Query: 481 SKEHEKLMEGELEA----LRQEFKKKDKTLKE--------------------NSRKLEEE 516
K E EL+A L E +K+ LK+ K E++
Sbjct: 1088 LKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQ 1147
Query: 517 NENLRAELQCCSTQLESSLNKYNTSQQVIQDLNKEIALQKESL----MSLQAQLDKALQK 572
+L EL+ T+LE +L+ T Q++ +E+ + K++L S +AQ+ + +
Sbjct: 1148 KRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQE--MR 1205
Query: 573 EKHYLQTTITKEAYDALSRKSAACQDDLTQALEKLN-HVTSETKSLQQSLTQTQEKKAQL 631
+KH E + R A D Q LEK N + E + L Q+ + + KK +L
Sbjct: 1206 QKHAQAVEELTEQLEQFKRAKANL-DKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKL 1264
Query: 632 EEEI--------------IAYEERMKKLNTELRKLRGFHQESELEVHAFDKKLEEMSCQV 677
E ++ +++ KL E+ + G E+E + K + +S Q+
Sbjct: 1265 EAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQL 1324
Query: 678 LQWQKQHQNDLKMLAAKEEQLREFQEEMAALKENLLEDDKEPCCLPQWSVP-----KDTC 732
Q+ Q + + +LR+ +EE +L++ L E+ + L + D+
Sbjct: 1325 QDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSK 1384
Query: 733 RLYRGNDQIMTNLEQWAKQQKVANEKLGNQLREQVKYIAKLSGEKDREPTRASSPNTTRP 792
+ + + LE+ K+ + E L Q E+ KL K+R
Sbjct: 1385 KKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNR------------- 1431
Query: 793 SSPSHSHLHSVMVHLQQENKKLKKEIEEKKMK-----AENTRLCTK-ALGPSRTESTQRE 846
L ++V L + ++L +E+K+ K AE + +K A R E+ RE
Sbjct: 1432 ---LQQELDDLVVDLDNQ-RQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEARE 1487
Query: 847 K 847
K
Sbjct: 1488 K 1488
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 118 bits (296), Expect = 2e-26
Identities = 175/892 (19%), Positives = 380/892 (42%), Gaps = 102/892 (11%)
Query: 10 EKLHLAQEQLALAGDKIASLERSLNLYRDKYQSSLSNIELLECQVKM---LQGELGGIMG 66
E++ +++L ++ E L K+ LL+ Q++ L E +
Sbjct: 859 EEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRV 918
Query: 67 QEPENKGDHSKVRIYTSPCMIQEHQETQKRLSEVWQKVSQQD-DLIQELRNKLACSNALV 125
+ K + ++ ++ ++E ++ ++L +K++QQ DL ++L + A L
Sbjct: 919 RLAAKKQELEEI-LHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQ 977
Query: 126 LER---EKALIKLQADFASCTATHRYPPSS----SEECEDIKKILKHLQEQKDSQCLHVE 178
LE+ E + KL+ + + E D+ L +E+ +
Sbjct: 978 LEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKN 1037
Query: 179 EYQNLVKDLRVELEAVSEQKRNIMKDMMKLELDLHGLREETSAHIERKDKDITILQCRLQ 238
++++++ +L V L+ + ++ + K KLE D E+ I LQ ++
Sbjct: 1038 KHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQ-----------IADLQAQIA 1086
Query: 239 ELQLEFT----ETQKLTLKKDKFLQEKDEMLQ---ELEKKLTQVQ----------NSLLK 281
EL+++ E Q + D + +K+ L+ ELE ++ +Q N K
Sbjct: 1087 ELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEK 1146
Query: 282 KEKEL-EKQQCMATELEMTVKE--------AKQDKSKEAECKALQAEVQKLKNSLEEAKQ 332
++++L E+ + + TELE T+ AK+++ KAL E + + ++E +Q
Sbjct: 1147 QKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQ 1206
Query: 333 QERLAAQQAAQCKEEAALAGCHLEDTQRKLQKG----------LLLDKQKAD-TIQELQR 381
+ A ++ + E+ A +L+ ++ L+K L KQ+ + ++L+
Sbjct: 1207 KHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEA 1266
Query: 382 ELQMLQKESSMAEKEQTSNRKRVEELSLELSEALRKLENSDKEKRQLQKTVAEQDMKMND 441
++Q LQ + S E+ + +V +L E+ L ++ + +L K VA ++ D
Sbjct: 1267 QVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQD 1326
Query: 442 MLDRIKHQHREQGSIKCKLEEDLQEATKLLEDKREQLKKSKEHEKLMEGELEALRQEFKK 501
+ ++ + R++ ++ KL + L+E L+D+ ++ ++K++ + L + KK
Sbjct: 1327 TQELLQEETRQKLNVSTKLRQ-LEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKK 1385
Query: 502 KDKTLKENSRKLEEENENLRAELQCCSTQLESSLNKY-------NTSQQVIQDLNKEIAL 554
K + LEE + + E++ + Q E Y N QQ + DL ++
Sbjct: 1386 KLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDN 1445
Query: 555 QKESLMSL---QAQLDKALQKEKHYLQTTITKEAYDALSRKSAACQDDLTQALEKLNHVT 611
Q++ + +L Q + D+ L +EK+ I+ + D R A ++ T+AL L
Sbjct: 1446 QRQLVSNLEKKQRKFDQLLAEEKN-----ISSKYADERDRAEAEAREKETKALS-LARAL 1499
Query: 612 SETKSLQQSLTQTQEK-KAQLEEEIIA----------YEERMKKLNTELRKLRGFHQESE 660
E ++ L +T + KA++E+ + + E+ + L T++ +++ +E E
Sbjct: 1500 EEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELE 1559
Query: 661 LEVHAFDKKLEEMSCQVLQWQKQHQNDLKMLAAKEEQLREFQEEMAALKENLLEDDKEPC 720
E+ A + + + + Q + DL+ + E+ R + E LED+++
Sbjct: 1560 DELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQR 1619
Query: 721 CLPQWSVPKDTCRLYRGNDQIMTNLEQWAKQQKVANEKLGNQLREQVKYIAKLSGE-KDR 779
L + K G+ + +LE A E+ QLR+ + E +D
Sbjct: 1620 ALAAAAKKK-----LEGD---LKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDA 1671
Query: 780 EPTRASSPNTTRPSSPSHSHLHSVMVHLQQ-----ENKKLKKEIEEKKMKAE 826
+R T + + L + ++ LQ+ E + + ++E++++ E
Sbjct: 1672 RASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEE 1723
Score = 117 bits (292), Expect = 6e-26
Identities = 170/953 (17%), Positives = 415/953 (43%), Gaps = 127/953 (13%)
Query: 1 MGNHNENTGEKLHLAQEQLALAGDKIASLE---RSLNLYRDKYQSSLSNIEL-------- 49
M + N ++ L +E+++ +A E ++L ++K++S +S +E+
Sbjct: 997 MDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKS 1056
Query: 50 ---LECQVKMLQGELGGIMGQEPENKGDHSKVRIYTSPCMIQEHQETQKRLSEVWQKVSQ 106
LE + L+G+ Q + + +++++ + ++ +E Q L+ + +++Q
Sbjct: 1057 RQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQ----LAKKEEELQAALARLDDEIAQ 1112
Query: 107 QD--------------DLIQELRNKLACSNALVLEREKALIKLQA------DFASCTATH 146
++ DL ++L ++ A N ++ +L+A D TAT
Sbjct: 1113 KNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQ 1172
Query: 147 RYPPSSSEECEDIKKILKHLQEQKDSQCLHVEE----YQNLVKDLRVELEAVSEQKRNIM 202
+ + E+ ++ + K L E+ S V+E + V++L +LE K N+
Sbjct: 1173 QELRAKREQ--EVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLD 1230
Query: 203 KDMMKLE---LDLHG---LREETSAHIERKDKDITILQCRLQELQLEFTETQKLTLKKDK 256
K+ LE DL G + + +E K K L+ ++QELQ + ++ ++ + +
Sbjct: 1231 KNKQTLEKENADLAGELRVLGQAKQEVEHKKKK---LEAQVQELQSKCSDGERARAELND 1287
Query: 257 FLQEKDEMLQELEKKLTQVQNSLLKKEKELEKQQCMATELEMTVKEAKQDKSKEAECKAL 316
+ + ++ + L + + +K K++ ++++L+ T + +++ ++
Sbjct: 1288 KVHKLQNEVESVTGMLNEAEGKAIKLAKDVAS---LSSQLQDTQELLQEETRQKLNVSTK 1344
Query: 317 QAEVQKLKNSLEEAKQQERLAAQQAAQCKEEAALAGCHLEDTQRKLQKGLLLDKQKADTI 376
++++ +NSL++ +E A Q + + L D+++KLQ + +
Sbjct: 1345 LRQLEEERNSLQDQLDEEMEAKQNL---ERHISTLNIQLSDSKKKLQDFASTVEALEEGK 1401
Query: 377 QELQRELQML-----QKESSMAEKEQTSNR--KRVEELSLELSEALRKLENSDKEKRQLQ 429
+ Q+E++ L +K ++ + E+T NR + +++L ++L + + N +K++R+
Sbjct: 1402 KRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFD 1461
Query: 430 KTVAEQ---DMKMNDMLDRIKHQHREQGSIKCKLEEDLQEATKLLEDKREQLKKSKEHEK 486
+ +AE+ K D DR + + RE+ + L L+EA + +E+L+++ + K
Sbjct: 1462 QLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEAL----EAKEELERTNKMLK 1517
Query: 487 LMEGELEALRQEFKKKDKTLKENSRKLEEENENLRAELQCCSTQLESSLNKYNTSQQVIQ 546
+L + + + K L+++ R LE + E ++ +L+ +L+++ + + +Q
Sbjct: 1518 AEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQ 1577
Query: 547 DLNKEIALQKESLMSLQAQLDKALQKEKHYLQTTITKEAYD-----ALSRKSAACQDDLT 601
L + ++ + + LQ++ H +T + E A +K DL
Sbjct: 1578 ALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLE 1637
Query: 602 -----------QALEKLNHVTSETKSLQQSLTQTQEKKAQLEEEIIAYEERMKKLNTELR 650
+A+++L + ++ K Q+ L + + ++ E++ K L +L
Sbjct: 1638 LQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLM 1697
Query: 651 KLRGFHQESELEVHAFDKKLEEMSCQV---LQWQKQHQNDLKMLAAK----EEQLREFQE 703
+L+ +E D + EE++ ++ L + Q++ + L A+ EE+L E Q
Sbjct: 1698 QLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQG 1757
Query: 704 EMAALKENLLEDDKEPCCLP-QWSVPKDTCRLYRGNDQIMTNLEQWAKQQKVANEKLGNQ 762
M A+ + + + ++ L + + + T + N+ LE+ K+ + ++
Sbjct: 1758 NMEAMSDRVRKATQQAEQLSNELATERSTAQK---NESARQQLERQNKELRSKLHEMEGA 1814
Query: 763 LREQVKY--------IAKLSGEKDREPTRASSPNTTRPSSPSHSHLHSVMVHLQQENK-- 812
++ + K IA+L + ++E + T+ L +++ ++ E K
Sbjct: 1815 VKSKFKSTIAALEAKIAQLEEQVEQEAREKQA--ATKSLKQKDKKLKEILLQVEDERKMA 1872
Query: 813 ---------------KLKKEIEEKKMKAENTRLCTKALGPSRTESTQREKVCG 850
+LK+++EE + +++ + L E+T+ + G
Sbjct: 1873 EQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMG 1925
Score = 114 bits (284), Expect = 5e-25
Identities = 199/917 (21%), Positives = 377/917 (41%), Gaps = 136/917 (14%)
Query: 17 EQLALAGDKIASLERSLNLYRDKYQSSLSNIELLECQVKMLQGELGGIMGQEPENKGDHS 76
EQ+A +IA L+ L ++ Q++L+ ++ Q ++ + G + + D
Sbjct: 1076 EQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLD 1135
Query: 77 KVRIYTSPCMIQEHQETQKRLSEVWQKVSQQDDLIQELRNKLACSNALVLEREKALIKLQ 136
R + E QKR ++ +++ +++ + A L +RE+ + L+
Sbjct: 1136 SERA------ARNKAEKQKR--DLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLK 1187
Query: 137 ADFASCTATH--RYPPSSSEECEDIKKILKHLQEQKDSQCLHVEEYQNLVK---DLRVEL 191
T +H + + + ++++ + L++ K ++ + Q L K DL EL
Sbjct: 1188 KALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGEL 1247
Query: 192 EAVSEQKRNIMKDMMKLELDLHGLREETS----AHIERKDKDITILQCRLQEL--QLEFT 245
+ + K+ + KLE + L+ + S A E DK + LQ ++ + L
Sbjct: 1248 RVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDK-VHKLQNEVESVTGMLNEA 1306
Query: 246 ETQKLTLKKD-----KFLQEKDEMLQELEKKLTQVQNSLLKKEKELEKQQCMATELEMTV 300
E + + L KD LQ+ E+LQE ++ V L + E+E Q E EM
Sbjct: 1307 EGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDE-EM-- 1363
Query: 301 KEAKQDKSKEAECKALQAEVQKLK--------NSLEEAKQQERLAAQQAAQCKEEAALAG 352
EAKQ+ + +Q K K +LEE K++ + + Q EE A A
Sbjct: 1364 -EAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAY 1422
Query: 353 CHLEDTQRKLQK---GLLLD----KQKADTIQELQRELQMLQKESSMAEKEQTSNRKRVE 405
LE T+ +LQ+ L++D +Q +++ QR+ L E + R R E
Sbjct: 1423 DKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAE 1482
Query: 406 ----ELSLELSEALRKLENSDKEKRQLQKTVAEQDMKMNDML---DRIKHQHREQGSIKC 458
E + R LE + + K +L++T +M D++ D + E K
Sbjct: 1483 AEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKR 1542
Query: 459 KLEEDLQEATKLLEDKREQLKKSKEHEKLMEGELEALRQEFKKKDKTLKENSRKLEEENE 518
LE ++E LE+ ++L+ +++ + +E ++AL+ +F ++ L+ + EE+
Sbjct: 1543 ALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQF---ERDLQARDEQNEEKRR 1599
Query: 519 NLRAELQCCSTQLESSLNKYNTSQQVIQDLN---KEIALQKES-----------LMSLQA 564
L+ +L T+LE + + + L K++ LQ +S L LQA
Sbjct: 1600 QLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQA 1659
Query: 565 QLD--------------------KALQKEKHYLQTTITKEAYDALSRKSAACQDDLT--Q 602
Q+ K +K+ L+ + + D + + A Q DL +
Sbjct: 1660 QMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEE 1719
Query: 603 ALEKLNHVTSETKSLQQSLTQTQEKKAQLEEEIIAYEERMKKLNTELRKLRGFHQESELE 662
E+L S +LQ + + + AQLEEE+ + M+ ++ +RK Q +L
Sbjct: 1720 LAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRK--ATQQAEQLS 1777
Query: 663 VHAFDKKLEEMSCQVLQWQKQHQNDLKMLAAKEEQLR-----EFQEEMAALKENL--LED 715
++ + + Q + QN K L +K ++ +F+ +AAL+ + LE+
Sbjct: 1778 NELATERSTAQKNESARQQLERQN--KELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEE 1835
Query: 716 DKEPCCLPQWSVPKDTCRLYRGNDQIMTNLE---QWAKQQKVANEKLGNQLREQVKYIAK 772
E + + K + + +I+ +E + A+Q K EK GN +VK + +
Sbjct: 1836 QVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEK-GN---ARVKQLKR 1891
Query: 773 LSGEKDREPTRASSPNTTRPSSPSHSHLHSVMVHLQQENKKLKKEIEE-----KKMKAEN 827
E + E R + +KL++E++E + M E
Sbjct: 1892 QLEEAEEESQR-----------------------INANRRKLQRELDEATESNEAMGREV 1928
Query: 828 TRLCTKALGPSRTESTQ 844
L +K GP E++Q
Sbjct: 1929 NALKSKLRGPPPQETSQ 1945
Score = 100 bits (249), Expect = 6e-21
Identities = 140/661 (21%), Positives = 277/661 (41%), Gaps = 115/661 (17%)
Query: 279 LLKKEKELEKQQCMATELEMTVKEAKQDKSKEAECKALQAEVQKLKNSLEEAKQQERLAA 338
LL+ ++ E+ Q EL+ T + ++ +++ E + +++ + KN L+E Q E
Sbjct: 851 LLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELY 910
Query: 339 QQAAQCKEEAALAGCHLEDTQRKLQKGLLLDKQKADTIQELQREL--QMLQKESSMAEKE 396
+A + + A LE+ +++ L ++ + +Q ++++ QML E + E+E
Sbjct: 911 AEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEE 970
Query: 397 QTSNRKRVEELSLELSEALRKLENS-----------DKEKRQLQKTV-------AEQDMK 438
+ ++E+++ E ++KLE+ KE++ L++ + AE++ K
Sbjct: 971 AARQKLQLEKVTAEAK--IKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEK 1028
Query: 439 MNDMLDRIKHQH------------------REQGSIKCKLEEDLQEATKLLEDKREQLKK 480
+ L ++K++H +E +K KLE D + + + D + Q+ +
Sbjct: 1029 AKN-LTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAE 1087
Query: 481 SKEHEKLMEGELEA----LRQEFKKKDKTLKE--------------------NSRKLEEE 516
K E EL+A L E +K+ LK+ K E++
Sbjct: 1088 LKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQ 1147
Query: 517 NENLRAELQCCSTQLESSLNKYNTSQQVIQDLNKEIALQKESL----MSLQAQLDKALQK 572
+L EL+ T+LE +L+ T Q++ +E+ + K++L S +AQ+ + +
Sbjct: 1148 KRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQE--MR 1205
Query: 573 EKHYLQTTITKEAYDALSRKSAACQDDLTQALEKLN-HVTSETKSLQQSLTQTQEKKAQL 631
+KH E + R A D Q LEK N + E + L Q+ + + KK +L
Sbjct: 1206 QKHAQAVEELTEQLEQFKRAKANL-DKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKL 1264
Query: 632 EEEI--------------IAYEERMKKLNTELRKLRGFHQESELEVHAFDKKLEEMSCQV 677
E ++ +++ KL E+ + G E+E + K + +S Q+
Sbjct: 1265 EAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQL 1324
Query: 678 LQWQKQHQNDLKMLAAKEEQLREFQEEMAALKENLLEDDKEPCCLPQWSVP-----KDTC 732
Q+ Q + + +LR+ +EE +L++ L E+ + L + D+
Sbjct: 1325 QDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSK 1384
Query: 733 RLYRGNDQIMTNLEQWAKQQKVANEKLGNQLREQVKYIAKLSGEKDREPTRASSPNTTRP 792
+ + + LE+ K+ + E L Q E+ KL K+R
Sbjct: 1385 KKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNR------------- 1431
Query: 793 SSPSHSHLHSVMVHLQQENKKLKKEIEEKKMK-----AENTRLCTK-ALGPSRTESTQRE 846
L ++V L + ++L +E+K+ K AE + +K A R E+ RE
Sbjct: 1432 ---LQQELDDLVVDLDNQ-RQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEARE 1487
Query: 847 K 847
K
Sbjct: 1488 K 1488
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 118 bits (296), Expect = 2e-26
Identities = 175/892 (19%), Positives = 380/892 (42%), Gaps = 102/892 (11%)
Query: 10 EKLHLAQEQLALAGDKIASLERSLNLYRDKYQSSLSNIELLECQVKM---LQGELGGIMG 66
E++ +++L ++ E L K+ LL+ Q++ L E +
Sbjct: 852 EEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRV 911
Query: 67 QEPENKGDHSKVRIYTSPCMIQEHQETQKRLSEVWQKVSQQD-DLIQELRNKLACSNALV 125
+ K + ++ ++ ++E ++ ++L +K++QQ DL ++L + A L
Sbjct: 912 RLAAKKQELEEI-LHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQ 970
Query: 126 LER---EKALIKLQADFASCTATHRYPPSS----SEECEDIKKILKHLQEQKDSQCLHVE 178
LE+ E + KL+ + + E D+ L +E+ +
Sbjct: 971 LEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKN 1030
Query: 179 EYQNLVKDLRVELEAVSEQKRNIMKDMMKLELDLHGLREETSAHIERKDKDITILQCRLQ 238
++++++ +L V L+ + ++ + K KLE D E+ I LQ ++
Sbjct: 1031 KHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQ-----------IADLQAQIA 1079
Query: 239 ELQLEFT----ETQKLTLKKDKFLQEKDEMLQ---ELEKKLTQVQ----------NSLLK 281
EL+++ E Q + D + +K+ L+ ELE ++ +Q N K
Sbjct: 1080 ELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEK 1139
Query: 282 KEKEL-EKQQCMATELEMTVKE--------AKQDKSKEAECKALQAEVQKLKNSLEEAKQ 332
++++L E+ + + TELE T+ AK+++ KAL E + + ++E +Q
Sbjct: 1140 QKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQ 1199
Query: 333 QERLAAQQAAQCKEEAALAGCHLEDTQRKLQKG----------LLLDKQKAD-TIQELQR 381
+ A ++ + E+ A +L+ ++ L+K L KQ+ + ++L+
Sbjct: 1200 KHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEA 1259
Query: 382 ELQMLQKESSMAEKEQTSNRKRVEELSLELSEALRKLENSDKEKRQLQKTVAEQDMKMND 441
++Q LQ + S E+ + +V +L E+ L ++ + +L K VA ++ D
Sbjct: 1260 QVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQD 1319
Query: 442 MLDRIKHQHREQGSIKCKLEEDLQEATKLLEDKREQLKKSKEHEKLMEGELEALRQEFKK 501
+ ++ + R++ ++ KL + L+E L+D+ ++ ++K++ + L + KK
Sbjct: 1320 TQELLQEETRQKLNVSTKLRQ-LEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKK 1378
Query: 502 KDKTLKENSRKLEEENENLRAELQCCSTQLESSLNKY-------NTSQQVIQDLNKEIAL 554
K + LEE + + E++ + Q E Y N QQ + DL ++
Sbjct: 1379 KLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDN 1438
Query: 555 QKESLMSL---QAQLDKALQKEKHYLQTTITKEAYDALSRKSAACQDDLTQALEKLNHVT 611
Q++ + +L Q + D+ L +EK+ I+ + D R A ++ T+AL L
Sbjct: 1439 QRQLVSNLEKKQRKFDQLLAEEKN-----ISSKYADERDRAEAEAREKETKALS-LARAL 1492
Query: 612 SETKSLQQSLTQTQEK-KAQLEEEIIA----------YEERMKKLNTELRKLRGFHQESE 660
E ++ L +T + KA++E+ + + E+ + L T++ +++ +E E
Sbjct: 1493 EEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELE 1552
Query: 661 LEVHAFDKKLEEMSCQVLQWQKQHQNDLKMLAAKEEQLREFQEEMAALKENLLEDDKEPC 720
E+ A + + + + Q + DL+ + E+ R + E LED+++
Sbjct: 1553 DELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQR 1612
Query: 721 CLPQWSVPKDTCRLYRGNDQIMTNLEQWAKQQKVANEKLGNQLREQVKYIAKLSGE-KDR 779
L + K G+ + +LE A E+ QLR+ + E +D
Sbjct: 1613 ALAAAAKKK-----LEGD---LKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDA 1664
Query: 780 EPTRASSPNTTRPSSPSHSHLHSVMVHLQQ-----ENKKLKKEIEEKKMKAE 826
+R T + + L + ++ LQ+ E + + ++E++++ E
Sbjct: 1665 RASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEE 1716
Score = 117 bits (292), Expect = 6e-26
Identities = 170/953 (17%), Positives = 415/953 (43%), Gaps = 127/953 (13%)
Query: 1 MGNHNENTGEKLHLAQEQLALAGDKIASLE---RSLNLYRDKYQSSLSNIEL-------- 49
M + N ++ L +E+++ +A E ++L ++K++S +S +E+
Sbjct: 990 MDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKS 1049
Query: 50 ---LECQVKMLQGELGGIMGQEPENKGDHSKVRIYTSPCMIQEHQETQKRLSEVWQKVSQ 106
LE + L+G+ Q + + +++++ + ++ +E Q L+ + +++Q
Sbjct: 1050 RQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQ----LAKKEEELQAALARLDDEIAQ 1105
Query: 107 QD--------------DLIQELRNKLACSNALVLEREKALIKLQA------DFASCTATH 146
++ DL ++L ++ A N ++ +L+A D TAT
Sbjct: 1106 KNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQ 1165
Query: 147 RYPPSSSEECEDIKKILKHLQEQKDSQCLHVEE----YQNLVKDLRVELEAVSEQKRNIM 202
+ + E+ ++ + K L E+ S V+E + V++L +LE K N+
Sbjct: 1166 QELRAKREQ--EVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLD 1223
Query: 203 KDMMKLE---LDLHG---LREETSAHIERKDKDITILQCRLQELQLEFTETQKLTLKKDK 256
K+ LE DL G + + +E K K L+ ++QELQ + ++ ++ + +
Sbjct: 1224 KNKQTLEKENADLAGELRVLGQAKQEVEHKKKK---LEAQVQELQSKCSDGERARAELND 1280
Query: 257 FLQEKDEMLQELEKKLTQVQNSLLKKEKELEKQQCMATELEMTVKEAKQDKSKEAECKAL 316
+ + ++ + L + + +K K++ ++++L+ T + +++ ++
Sbjct: 1281 KVHKLQNEVESVTGMLNEAEGKAIKLAKDVAS---LSSQLQDTQELLQEETRQKLNVSTK 1337
Query: 317 QAEVQKLKNSLEEAKQQERLAAQQAAQCKEEAALAGCHLEDTQRKLQKGLLLDKQKADTI 376
++++ +NSL++ +E A Q + + L D+++KLQ + +
Sbjct: 1338 LRQLEEERNSLQDQLDEEMEAKQNL---ERHISTLNIQLSDSKKKLQDFASTVEALEEGK 1394
Query: 377 QELQRELQML-----QKESSMAEKEQTSNR--KRVEELSLELSEALRKLENSDKEKRQLQ 429
+ Q+E++ L +K ++ + E+T NR + +++L ++L + + N +K++R+
Sbjct: 1395 KRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFD 1454
Query: 430 KTVAEQ---DMKMNDMLDRIKHQHREQGSIKCKLEEDLQEATKLLEDKREQLKKSKEHEK 486
+ +AE+ K D DR + + RE+ + L L+EA + +E+L+++ + K
Sbjct: 1455 QLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEAL----EAKEELERTNKMLK 1510
Query: 487 LMEGELEALRQEFKKKDKTLKENSRKLEEENENLRAELQCCSTQLESSLNKYNTSQQVIQ 546
+L + + + K L+++ R LE + E ++ +L+ +L+++ + + +Q
Sbjct: 1511 AEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQ 1570
Query: 547 DLNKEIALQKESLMSLQAQLDKALQKEKHYLQTTITKEAYD-----ALSRKSAACQDDLT 601
L + ++ + + LQ++ H +T + E A +K DL
Sbjct: 1571 ALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLE 1630
Query: 602 -----------QALEKLNHVTSETKSLQQSLTQTQEKKAQLEEEIIAYEERMKKLNTELR 650
+A+++L + ++ K Q+ L + + ++ E++ K L +L
Sbjct: 1631 LQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLM 1690
Query: 651 KLRGFHQESELEVHAFDKKLEEMSCQV---LQWQKQHQNDLKMLAAK----EEQLREFQE 703
+L+ +E D + EE++ ++ L + Q++ + L A+ EE+L E Q
Sbjct: 1691 QLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQG 1750
Query: 704 EMAALKENLLEDDKEPCCLP-QWSVPKDTCRLYRGNDQIMTNLEQWAKQQKVANEKLGNQ 762
M A+ + + + ++ L + + + T + N+ LE+ K+ + ++
Sbjct: 1751 NMEAMSDRVRKATQQAEQLSNELATERSTAQK---NESARQQLERQNKELRSKLHEMEGA 1807
Query: 763 LREQVKY--------IAKLSGEKDREPTRASSPNTTRPSSPSHSHLHSVMVHLQQENK-- 812
++ + K IA+L + ++E + T+ L +++ ++ E K
Sbjct: 1808 VKSKFKSTIAALEAKIAQLEEQVEQEAREKQA--ATKSLKQKDKKLKEILLQVEDERKMA 1865
Query: 813 ---------------KLKKEIEEKKMKAENTRLCTKALGPSRTESTQREKVCG 850
+LK+++EE + +++ + L E+T+ + G
Sbjct: 1866 EQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMG 1918
Score = 114 bits (284), Expect = 5e-25
Identities = 199/917 (21%), Positives = 377/917 (41%), Gaps = 136/917 (14%)
Query: 17 EQLALAGDKIASLERSLNLYRDKYQSSLSNIELLECQVKMLQGELGGIMGQEPENKGDHS 76
EQ+A +IA L+ L ++ Q++L+ ++ Q ++ + G + + D
Sbjct: 1069 EQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLD 1128
Query: 77 KVRIYTSPCMIQEHQETQKRLSEVWQKVSQQDDLIQELRNKLACSNALVLEREKALIKLQ 136
R + E QKR ++ +++ +++ + A L +RE+ + L+
Sbjct: 1129 SERA------ARNKAEKQKR--DLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLK 1180
Query: 137 ADFASCTATH--RYPPSSSEECEDIKKILKHLQEQKDSQCLHVEEYQNLVK---DLRVEL 191
T +H + + + ++++ + L++ K ++ + Q L K DL EL
Sbjct: 1181 KALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGEL 1240
Query: 192 EAVSEQKRNIMKDMMKLELDLHGLREETS----AHIERKDKDITILQCRLQEL--QLEFT 245
+ + K+ + KLE + L+ + S A E DK + LQ ++ + L
Sbjct: 1241 RVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDK-VHKLQNEVESVTGMLNEA 1299
Query: 246 ETQKLTLKKD-----KFLQEKDEMLQELEKKLTQVQNSLLKKEKELEKQQCMATELEMTV 300
E + + L KD LQ+ E+LQE ++ V L + E+E Q E EM
Sbjct: 1300 EGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDE-EM-- 1356
Query: 301 KEAKQDKSKEAECKALQAEVQKLK--------NSLEEAKQQERLAAQQAAQCKEEAALAG 352
EAKQ+ + +Q K K +LEE K++ + + Q EE A A
Sbjct: 1357 -EAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAY 1415
Query: 353 CHLEDTQRKLQK---GLLLD----KQKADTIQELQRELQMLQKESSMAEKEQTSNRKRVE 405
LE T+ +LQ+ L++D +Q +++ QR+ L E + R R E
Sbjct: 1416 DKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAE 1475
Query: 406 ----ELSLELSEALRKLENSDKEKRQLQKTVAEQDMKMNDML---DRIKHQHREQGSIKC 458
E + R LE + + K +L++T +M D++ D + E K
Sbjct: 1476 AEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKR 1535
Query: 459 KLEEDLQEATKLLEDKREQLKKSKEHEKLMEGELEALRQEFKKKDKTLKENSRKLEEENE 518
LE ++E LE+ ++L+ +++ + +E ++AL+ +F ++ L+ + EE+
Sbjct: 1536 ALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQF---ERDLQARDEQNEEKRR 1592
Query: 519 NLRAELQCCSTQLESSLNKYNTSQQVIQDLN---KEIALQKES-----------LMSLQA 564
L+ +L T+LE + + + L K++ LQ +S L LQA
Sbjct: 1593 QLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQA 1652
Query: 565 QLD--------------------KALQKEKHYLQTTITKEAYDALSRKSAACQDDLT--Q 602
Q+ K +K+ L+ + + D + + A Q DL +
Sbjct: 1653 QMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEE 1712
Query: 603 ALEKLNHVTSETKSLQQSLTQTQEKKAQLEEEIIAYEERMKKLNTELRKLRGFHQESELE 662
E+L S +LQ + + + AQLEEE+ + M+ ++ +RK Q +L
Sbjct: 1713 LAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRK--ATQQAEQLS 1770
Query: 663 VHAFDKKLEEMSCQVLQWQKQHQNDLKMLAAKEEQLR-----EFQEEMAALKENL--LED 715
++ + + Q + QN K L +K ++ +F+ +AAL+ + LE+
Sbjct: 1771 NELATERSTAQKNESARQQLERQN--KELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEE 1828
Query: 716 DKEPCCLPQWSVPKDTCRLYRGNDQIMTNLE---QWAKQQKVANEKLGNQLREQVKYIAK 772
E + + K + + +I+ +E + A+Q K EK GN +VK + +
Sbjct: 1829 QVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEK-GN---ARVKQLKR 1884
Query: 773 LSGEKDREPTRASSPNTTRPSSPSHSHLHSVMVHLQQENKKLKKEIEE-----KKMKAEN 827
E + E R + +KL++E++E + M E
Sbjct: 1885 QLEEAEEESQR-----------------------INANRRKLQRELDEATESNEAMGREV 1921
Query: 828 TRLCTKALGPSRTESTQ 844
L +K GP E++Q
Sbjct: 1922 NALKSKLRGPPPQETSQ 1938
Score = 100 bits (249), Expect = 6e-21
Identities = 140/661 (21%), Positives = 277/661 (41%), Gaps = 115/661 (17%)
Query: 279 LLKKEKELEKQQCMATELEMTVKEAKQDKSKEAECKALQAEVQKLKNSLEEAKQQERLAA 338
LL+ ++ E+ Q EL+ T + ++ +++ E + +++ + KN L+E Q E
Sbjct: 844 LLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELY 903
Query: 339 QQAAQCKEEAALAGCHLEDTQRKLQKGLLLDKQKADTIQELQREL--QMLQKESSMAEKE 396
+A + + A LE+ +++ L ++ + +Q ++++ QML E + E+E
Sbjct: 904 AEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEE 963
Query: 397 QTSNRKRVEELSLELSEALRKLENS-----------DKEKRQLQKTV-------AEQDMK 438
+ ++E+++ E ++KLE+ KE++ L++ + AE++ K
Sbjct: 964 AARQKLQLEKVTAEAK--IKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEK 1021
Query: 439 MNDMLDRIKHQH------------------REQGSIKCKLEEDLQEATKLLEDKREQLKK 480
+ L ++K++H +E +K KLE D + + + D + Q+ +
Sbjct: 1022 AKN-LTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAE 1080
Query: 481 SKEHEKLMEGELEA----LRQEFKKKDKTLKE--------------------NSRKLEEE 516
K E EL+A L E +K+ LK+ K E++
Sbjct: 1081 LKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQ 1140
Query: 517 NENLRAELQCCSTQLESSLNKYNTSQQVIQDLNKEIALQKESL----MSLQAQLDKALQK 572
+L EL+ T+LE +L+ T Q++ +E+ + K++L S +AQ+ + +
Sbjct: 1141 KRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQE--MR 1198
Query: 573 EKHYLQTTITKEAYDALSRKSAACQDDLTQALEKLN-HVTSETKSLQQSLTQTQEKKAQL 631
+KH E + R A D Q LEK N + E + L Q+ + + KK +L
Sbjct: 1199 QKHAQAVEELTEQLEQFKRAKANL-DKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKL 1257
Query: 632 EEEI--------------IAYEERMKKLNTELRKLRGFHQESELEVHAFDKKLEEMSCQV 677
E ++ +++ KL E+ + G E+E + K + +S Q+
Sbjct: 1258 EAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQL 1317
Query: 678 LQWQKQHQNDLKMLAAKEEQLREFQEEMAALKENLLEDDKEPCCLPQWSVP-----KDTC 732
Q+ Q + + +LR+ +EE +L++ L E+ + L + D+
Sbjct: 1318 QDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSK 1377
Query: 733 RLYRGNDQIMTNLEQWAKQQKVANEKLGNQLREQVKYIAKLSGEKDREPTRASSPNTTRP 792
+ + + LE+ K+ + E L Q E+ KL K+R
Sbjct: 1378 KKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNR------------- 1424
Query: 793 SSPSHSHLHSVMVHLQQENKKLKKEIEEKKMK-----AENTRLCTK-ALGPSRTESTQRE 846
L ++V L + ++L +E+K+ K AE + +K A R E+ RE
Sbjct: 1425 ---LQQELDDLVVDLDNQ-RQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEARE 1480
Query: 847 K 847
K
Sbjct: 1481 K 1481
>gi|16262452 cingulin [Homo sapiens]
Length = 1203
Score = 118 bits (295), Expect = 3e-26
Identities = 174/816 (21%), Positives = 345/816 (42%), Gaps = 133/816 (16%)
Query: 50 LECQVKMLQGELGGIMGQEPENKGDHSKVRIYTSPCMIQEHQETQKRLSEVWQKVSQQDD 109
LE QV LQ +L + G EP + ++++ ET++ L EV + + ++
Sbjct: 441 LETQVMELQNKLKHVQGPEPAKE------------VLLKDLLETRELLEEVLEGKQRVEE 488
Query: 110 LIQELRNKLACSNALVLEREKALIKLQADFASCTATHRYPPSSSEECEDIKKILKHLQEQ 169
++ + ERE +K + + D +++ + +Q+
Sbjct: 489 QLR------------LRERELTALKGALKEEVASRDQEVEHVRQQYQRDTEQLRRSMQDA 536
Query: 170 KDSQCLHVEEYQN---LVKDLRVELEAVSEQKRNIMKDMMKLELDLHGLREET-SAHIER 225
+ E Q LV+ L+ ELE SE+ + K + DL ++E +E+
Sbjct: 537 TQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKEDLRATKQELLQLRMEK 596
Query: 226 KDKD------ITILQCRLQELQLEFTETQKLTLKKDKFLQEKDEMLQELEKKLTQVQNSL 279
++ + I +LQ L++ + +T+++ + K + L+ ++E L+EL+ + + +
Sbjct: 597 EEMEEELGEKIEVLQRELEQARASAGDTRQVEVLKKELLRTQEE-LKELQAERQSQEVAG 655
Query: 280 LKKEKELEKQQCMATELEMTVKEAKQDKSKEAECKALQAE--VQKLKNSLEEAKQQERLA 337
+++ELEKQ + V + D+ +E E + LQ + +Q+L+ EEA + + +A
Sbjct: 656 RHRDRELEKQ--------LAVLRVEADRGRELEEQNLQLQKTLQQLRQDCEEASKAKMVA 707
Query: 338 AQQAAQCKEEAALAGCHLEDTQR----------------KLQKGLL-----LDKQKADTI 376
+A + A L +TQ K +GL+ ++ + D +
Sbjct: 708 EAEATVLGQRRAAVETTLRETQEENDEFRRRILGLEQQLKETRGLVDGGEAVEARLRDKL 767
Query: 377 QELQRELQMLQKESSMAEKEQTSNRKRVEELSLELSEALRKLENSDKEKRQLQKTVAEQD 436
Q L+ E Q L++ + +++E+ S L L EA R L +E++ L + + E++
Sbjct: 768 QRLEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTLNRAL-EEE 826
Query: 437 MKMNDMLDRIKHQHREQGSIKCKLEEDLQEATKLLEDKREQLKKSKEHEKLMEGELEALR 496
K ++L R K +L+E +LL+ ++L +KE EK+ E +AL+
Sbjct: 827 GKQREVLRRGK--------------AELEEQKRLLDRTVDRL--NKELEKIGEDSKQALQ 870
Query: 497 QEFKKKDKTLKENSRKLEEENENLRAELQCCSTQLESSLNKYNTSQQVIQDLNKEIALQK 556
Q +LE+ E R E+ Q + ++ + + L EI +
Sbjct: 871 QL-----------QAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLR 919
Query: 557 ESLMSLQAQLDKALQKEKHYLQTTITKEAYDALSRKSAACQDDLTQALEKLNHVTSETKS 616
++L + QA+ D A + +K L + +A ++K + QDD + L+ L S
Sbjct: 920 QALQASQAERDTA-RLDKELLAQRLQGLEQEAENKKRS--QDDRARQLKGLEEKVSR--- 973
Query: 617 LQQSLTQTQEKKAQLEEEIIAYEERMKKLNTELRKLRGFHQESELEVHAFDKKLEEMSCQ 676
L+ L + + L + + +++ +L TEL + R Q+ E C
Sbjct: 974 LETELDEEKNTVELLTDRVNRGRDQVDQLRTELMQERSARQDLE--------------CD 1019
Query: 677 VLQWQKQHQNDLKMLAAKEE-------QLREFQEEMAALKENLLEDDKEPCCLPQWSVPK 729
+ ++Q++ DLK A E L + + + L+E L +++E L
Sbjct: 1020 KISLERQNK-DLKTRLASSEGFQKPSASLSQLESQNQLLQERLQAEEREKTVL-----QS 1073
Query: 730 DTCRLYRGNDQIMTNLEQWAKQQKVANEKLGNQLREQVKYIAKLSGEKDREPTRASSPNT 789
+L R ++ +E ++Q V ++K +QL +VK + + E + E R
Sbjct: 1074 TNRKLERKVKELSIQIED--ERQHVNDQK--DQLSLRVKALKRQVDEAEEEIERLD--GL 1127
Query: 790 TRPSSPSHSHLHSVMVHLQQENKKLKKEIEEKKMKA 825
+ + H V LQ K L+K+ K ++
Sbjct: 1128 RKKAQREVEEQHEVNEQLQARIKSLEKDSWRKASRS 1163
Score = 80.1 bits (196), Expect = 8e-15
Identities = 118/504 (23%), Positives = 216/504 (42%), Gaps = 87/504 (17%)
Query: 376 IQELQRELQMLQKESSMAEKEQTSNRKRVEELSLELSEALRKLENSDKEKRQLQKTVAEQ 435
++ELQR+L K+ E Q +++EE + E S LE E +Q K +
Sbjct: 368 VEELQRKLDEEVKKRQKLEPSQVGLERQLEEKTEECSRLQELLERRKGEAQQSNKELQNM 427
Query: 436 --------------DMKMNDMLDRIKHQHREQGSIKCKLEEDLQEATKLLEDKREQLKKS 481
+ ++ ++ +++KH + + K L +DL E +LLE+ E ++
Sbjct: 428 KRLLDQGEDLRHGLETQVMELQNKLKHVQGPEPA-KEVLLKDLLETRELLEEVLEGKQRV 486
Query: 482 KEHEKLMEGELEALRQEFKKKDKTLKENSRKLEEENENLRAELQCCSTQLESSLNKYNTS 541
+E +L E EL AL+ LKE ++E E++R + Q + QL S+
Sbjct: 487 EEQLRLRERELTALK-------GALKEEVASRDQEVEHVRQQYQRDTEQLRRSMQDATQD 539
Query: 542 QQVIQDLNKEIALQKESLM--SLQAQLDKALQKEKHYLQTTITKEAYDALSRKSAACQ-- 597
V+ E QK S + LQ +L++ ++ H+ Q+ K D + K Q
Sbjct: 540 HAVL-----EAERQKMSALVRGLQRELEETSEETGHW-QSMFQKNKEDLRATKQELLQLR 593
Query: 598 ---DDLTQAL-EKLNHVTSETKSLQQSLTQTQEKKAQLEEEIIAYEERMKKLNTE--LRK 651
+++ + L EK+ + E + + S T++ + L++E++ +E +K+L E ++
Sbjct: 594 MEKEEMEEELGEKIEVLQRELEQARASAGDTRQVEV-LKKELLRTQEELKELQAERQSQE 652
Query: 652 LRGFHQESELEVHAF--------DKKLEEMSCQVLQWQKQHQND------LKML------ 691
+ G H++ ELE ++LEE + Q+ + +Q + D KM+
Sbjct: 653 VAGRHRDRELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQDCEEASKAKMVAEAEAT 712
Query: 692 ------AAKEEQLREFQEEMAALKENLLEDDKEPCCLPQWSVPKDTCRLYRGNDQIMTNL 745
AA E LRE QEE + +L +++ K+T L G + + L
Sbjct: 713 VLGQRRAAVETTLRETQEENDEFRRRILGLEQQ---------LKETRGLVDGGEAVEARL 763
Query: 746 EQWAKQQKVANEKLGNQLREQVKYIAKLSGEKDREPTRASSPNTTRPSSPSHSHLHSVMV 805
K Q++ EK QL E L+ ++ E + A++ R +
Sbjct: 764 RD--KLQRLEAEK--QQLEE------ALNASQEEEGSLAAA---KRALEARLEEAQRGLA 810
Query: 806 HLQQENKKLKKEIEEKKMKAENTR 829
L QE + L + +EE+ + E R
Sbjct: 811 RLGQEQQTLNRALEEEGKQREVLR 834
Score = 79.7 bits (195), Expect = 1e-14
Identities = 138/631 (21%), Positives = 260/631 (41%), Gaps = 102/631 (16%)
Query: 236 RLQELQLEFTETQKLTLKKD-------KFLQEKDEMLQELEKKLTQVQNSLLKKEKELEK 288
+++ELQ + E K K + + L+EK E L++ L + + + KEL+
Sbjct: 367 KVEELQRKLDEEVKKRQKLEPSQVGLERQLEEKTEECSRLQELLERRKGEAQQSNKELQN 426
Query: 289 QQCMATE-------LEMTVKE----AKQDKSKEAECKALQAEVQKLKNSLEEAKQ-QERL 336
+ + + LE V E K + E + L ++ + + LEE + ++R+
Sbjct: 427 MKRLLDQGEDLRHGLETQVMELQNKLKHVQGPEPAKEVLLKDLLETRELLEEVLEGKQRV 486
Query: 337 AAQQAAQCKEEAALAGCHLEDTQRKLQKGLLLDKQKADTIQELQRELQMLQKESSMAEKE 396
Q + +E AL G E+ + D++ Q+ QR+ + L++ A ++
Sbjct: 487 EEQLRLRERELTALKGALKEEVASR-------DQEVEHVRQQYQRDTEQLRRSMQDATQD 539
Query: 397 QTSNRKRVEELSLELSEALRKLENSDKEKRQLQKTVAEQDMKMNDMLDRIKHQHREQGSI 456
+++S + R+LE + +E Q K + L K + +
Sbjct: 540 HAVLEAERQKMSALVRGLQRELEETSEETGHWQSMF----QKNKEDLRATKQELLQLRME 595
Query: 457 KCKLEEDLQEATKLLEDKREQLKKSKEHEKLME----------GELEALRQEFKKKDKTL 506
K ++EE+L E ++L+ + EQ + S + +E EL+ L+ E + ++
Sbjct: 596 KEEMEEELGEKIEVLQRELEQARASAGDTRQVEVLKKELLRTQEELKELQAERQSQEVAG 655
Query: 507 KENSRKLEEENENLRAELQCCSTQLESSLNKYNTSQQVIQDLNKEIALQKESLMSLQAQL 566
+ R+LE++ LR E E +L T QQ+ QD E A + + + +A +
Sbjct: 656 RHRDRELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQDC--EEASKAKMVAEAEATV 713
Query: 567 DKALQKEKHYLQTTI--TKEAYDALSRKSAACQDDLTQA--------------LEKLNHV 610
L + + ++TT+ T+E D R+ + L + +KL +
Sbjct: 714 ---LGQRRAAVETTLRETQEENDEFRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQRL 770
Query: 611 TSETKSLQQSLTQTQEKKAQLEEEIIAYEERMKKLNTELRKL--------RGFHQE---- 658
+E + L+++L +QE++ L A E R+++ L +L R +E
Sbjct: 771 EAEKQQLEEALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTLNRALEEEGKQR 830
Query: 659 -------SELE---------VHAFDKKLE---EMSCQVLQWQKQHQNDLKMLAAKE---- 695
+ELE V +K+LE E S Q LQ + D K A +E
Sbjct: 831 EVLRRGKAELEEQKRLLDRTVDRLNKELEKIGEDSKQALQQLQAQLEDYKEKARREVADA 890
Query: 696 -EQLREFQEEMAALKENL--LEDDKEPC--CLPQWSVPKDTCRLYRG-NDQIMTNLEQWA 749
Q +++ E L L+D+ + L +DT RL + Q + LEQ A
Sbjct: 891 QRQAKDWASEAEKTSGGLSRLQDEIQRLRQALQASQAERDTARLDKELLAQRLQGLEQEA 950
Query: 750 KQQKVANEKLGNQLREQVKYIAKLSGEKDRE 780
+ +K + + QL+ + +++L E D E
Sbjct: 951 ENKKRSQDDRARQLKGLEEKVSRLETELDEE 981
Score = 53.1 bits (126), Expect = 1e-06
Identities = 77/367 (20%), Positives = 158/367 (43%), Gaps = 63/367 (17%)
Query: 359 QRKLQKGLLLDKQKA---DTIQELQRELQMLQKESSMAEKEQTSNRKRVEELSLELSEAL 415
Q K LL D+Q+A ++ ++ + + +E S + +TS R++V L LE + L
Sbjct: 291 QFKSTPDLLRDQQEAAPPGSVDHMKATIYGILREGS--SESETSVRRKVS-LVLEKMQPL 347
Query: 416 RKLENSDKE----KRQLQKTVAEQDMKMNDMLDRIKHQHREQGSIKCKLEEDLQEATKLL 471
+ + + + +L + V E K+++ + K Q E + LE L+E T+
Sbjct: 348 VMVSSGSTKAVAGQGELTRKVEELQRKLDEEVK--KRQKLEPSQVG--LERQLEEKTEEC 403
Query: 472 EDKREQLKKSKEHEKLMEGELEALRQEFKKKDKTLKENSRKLEEENENLRAELQCCSTQL 531
+E L++ K GE + +E +N ++L ++ E+LR L+ +L
Sbjct: 404 SRLQELLERRK-------GEAQQSNKEL--------QNMKRLLDQGEDLRHGLETQVMEL 448
Query: 532 ESSLNKYNTSQQVIQDLNKEIALQKESLMSLQAQLDKALQKEKHYLQTTITKEAYDALSR 591
++ L + KE+ L + L+ + L++ L+ ++ + +E L+
Sbjct: 449 QNKLKHVQGPEPA-----KEVLL--KDLLETRELLEEVLEGKQRVEEQLRLRER--ELTA 499
Query: 592 KSAACQDDLTQALEKLNHVTS----ETKSLQQSLTQTQEKKAQLEEEIIAYEERMKKLNT 647
A ++++ +++ HV +T+ L++S+ + A LE E
Sbjct: 500 LKGALKEEVASRDQEVEHVRQQYQRDTEQLRRSMQDATQDHAVLEAE------------- 546
Query: 648 ELRKLRGFHQESELEVHAFDKKLEEMSCQVLQWQKQHQNDLKMLAAKEEQLREFQEEMAA 707
Q+ V ++LEE S + WQ Q + + L A +++L + + E
Sbjct: 547 --------RQKMSALVRGLQRELEETSEETGHWQSMFQKNKEDLRATKQELLQLRMEKEE 598
Query: 708 LKENLLE 714
++E L E
Sbjct: 599 MEEELGE 605
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.309 0.124 0.334
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 31,543,904
Number of Sequences: 37866
Number of extensions: 1506323
Number of successful extensions: 33937
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 753
Number of HSP's successfully gapped in prelim test: 1478
Number of HSP's that attempted gapping in prelim test: 8711
Number of HSP's gapped (non-prelim): 9445
length of query: 882
length of database: 18,247,518
effective HSP length: 111
effective length of query: 771
effective length of database: 14,044,392
effective search space: 10828226232
effective search space used: 10828226232
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.