Guide to the Human Genome
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Search of human proteins with 116174780

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|116174780 SEC24 related gene family, member A [Homo sapiens]
         (1093 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|116174780 SEC24 related gene family, member A [Homo sapiens]      2199   0.0  
gi|112382214 SEC24 (S. cerevisiae) homolog B isoform b [Homo sap...  1235   0.0  
gi|112382212 SEC24 (S. cerevisiae) homolog B isoform a [Homo sap...  1229   0.0  
gi|38373671 SEC24-related protein C [Homo sapiens]                    395   e-109
gi|38373669 SEC24-related protein C [Homo sapiens]                    395   e-109
gi|190343021 Sec24-related protein D [Homo sapiens]                   357   3e-98
gi|14591924 Sec23 homolog B [Homo sapiens]                             75   3e-13
gi|14591926 Sec23 homolog B [Homo sapiens]                             75   3e-13
gi|14591928 Sec23 homolog B [Homo sapiens]                             75   3e-13
gi|38202214 SEC23-related protein A [Homo sapiens]                     67   9e-11
gi|54860079 nadrin isoform 1 [Homo sapiens]                            65   3e-10
gi|54860105 nadrin isoform 2 [Homo sapiens]                            65   3e-10
gi|150417989 cyclin K isoform 1 [Homo sapiens]                         62   3e-09
gi|163965366 nascent polypeptide-associated complex alpha subuni...    62   3e-09
gi|151301154 mucin 6, gastric [Homo sapiens]                           60   1e-08
gi|42544125 splicing factor 1 isoform 2 [Homo sapiens]                 59   2e-08
gi|42544130 splicing factor 1 isoform 1 [Homo sapiens]                 59   3e-08
gi|188497758 ubiquitin associated protein 2-like isoform a [Homo...    59   3e-08
gi|188497756 ubiquitin associated protein 2-like isoform b [Homo...    59   3e-08
gi|163914392 glioma tumor suppressor candidate region gene 1 [Ho...    58   4e-08
gi|116284392 mucin 2 precursor [Homo sapiens]                          57   1e-07
gi|34365793 WNK lysine deficient protein kinase 4 [Homo sapiens]       56   2e-07
gi|125858485 hypothetical protein LOC80209 isoform 2 [Homo sapiens]    55   5e-07
gi|125656155 hypothetical protein LOC80209 isoform 1 [Homo sapiens]    55   5e-07
gi|116284398 WAS/WASL interacting protein family, member 1 [Homo...    54   1e-06
gi|38373695 WAS/WASL interacting protein family, member 1 [Homo ...    54   1e-06
gi|31543543 retinoic acid induced 17 [Homo sapiens]                    53   1e-06
gi|153945878 mucin 5, subtype B, tracheobronchial [Homo sapiens]       52   3e-06
gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo ...    52   4e-06
gi|31543535 R3H domain containing 1 [Homo sapiens]                     52   4e-06

>gi|116174780 SEC24 related gene family, member A [Homo sapiens]
          Length = 1093

 Score = 2199 bits (5698), Expect = 0.0
 Identities = 1093/1093 (100%), Positives = 1093/1093 (100%)

Query: 1    MSQPGIPASGGAPASLQAQNGAALASGSPYTNGPVQNALLSSQESVSQGYNFQLPGSYPH 60
            MSQPGIPASGGAPASLQAQNGAALASGSPYTNGPVQNALLSSQESVSQGYNFQLPGSYPH
Sbjct: 1    MSQPGIPASGGAPASLQAQNGAALASGSPYTNGPVQNALLSSQESVSQGYNFQLPGSYPH 60

Query: 61   PIPAKTLNPVSGQSNYGGSQGSGQTLNRPPVASNPVTPSLHSGPAPRMPLPASQNPATTP 120
            PIPAKTLNPVSGQSNYGGSQGSGQTLNRPPVASNPVTPSLHSGPAPRMPLPASQNPATTP
Sbjct: 61   PIPAKTLNPVSGQSNYGGSQGSGQTLNRPPVASNPVTPSLHSGPAPRMPLPASQNPATTP 120

Query: 121  MPSSSFLPEANLPPPLNWQYNYPSTASQTNHCPRASSQPTVSGNTSLTTNHQYVSSGYPS 180
            MPSSSFLPEANLPPPLNWQYNYPSTASQTNHCPRASSQPTVSGNTSLTTNHQYVSSGYPS
Sbjct: 121  MPSSSFLPEANLPPPLNWQYNYPSTASQTNHCPRASSQPTVSGNTSLTTNHQYVSSGYPS 180

Query: 181  LQNSFIKSGPSVPPLVNPPLPTTFQPGAPHGPPPAGGPPPVRALTPLTSSYRDVPQPLFN 240
            LQNSFIKSGPSVPPLVNPPLPTTFQPGAPHGPPPAGGPPPVRALTPLTSSYRDVPQPLFN
Sbjct: 181  LQNSFIKSGPSVPPLVNPPLPTTFQPGAPHGPPPAGGPPPVRALTPLTSSYRDVPQPLFN 240

Query: 241  SAVNQEGITSNTNNGSMVVHSSYDEIEGGGLLATPQLTNKNPKMSRSVGYSYPSLPPGYQ 300
            SAVNQEGITSNTNNGSMVVHSSYDEIEGGGLLATPQLTNKNPKMSRSVGYSYPSLPPGYQ
Sbjct: 241  SAVNQEGITSNTNNGSMVVHSSYDEIEGGGLLATPQLTNKNPKMSRSVGYSYPSLPPGYQ 300

Query: 301  NTTPPGATGVPPSSLNYPSGPQAFTQTPLGANHLTTSMSGLSLQPEGLRVVNLLQERNML 360
            NTTPPGATGVPPSSLNYPSGPQAFTQTPLGANHLTTSMSGLSLQPEGLRVVNLLQERNML
Sbjct: 301  NTTPPGATGVPPSSLNYPSGPQAFTQTPLGANHLTTSMSGLSLQPEGLRVVNLLQERNML 360

Query: 361  PSTPLKPPVPNLHEDIQKLNCNPELFRCTLTSIPQTQALLNKAKLPLGLLLHPFKDLVQL 420
            PSTPLKPPVPNLHEDIQKLNCNPELFRCTLTSIPQTQALLNKAKLPLGLLLHPFKDLVQL
Sbjct: 361  PSTPLKPPVPNLHEDIQKLNCNPELFRCTLTSIPQTQALLNKAKLPLGLLLHPFKDLVQL 420

Query: 421  PVVTSSTIVRCRSCRTYINPFVSFLDQRRWKCNLCYRVNDVPEEFLYNPLTRVYGEPHRR 480
            PVVTSSTIVRCRSCRTYINPFVSFLDQRRWKCNLCYRVNDVPEEFLYNPLTRVYGEPHRR
Sbjct: 421  PVVTSSTIVRCRSCRTYINPFVSFLDQRRWKCNLCYRVNDVPEEFLYNPLTRVYGEPHRR 480

Query: 481  PEVQNATIEFMAPSEYMLRPPQPPVYLFVFDVSHNAVETGYLNSVCQSLLDNLDLLPGNT 540
            PEVQNATIEFMAPSEYMLRPPQPPVYLFVFDVSHNAVETGYLNSVCQSLLDNLDLLPGNT
Sbjct: 481  PEVQNATIEFMAPSEYMLRPPQPPVYLFVFDVSHNAVETGYLNSVCQSLLDNLDLLPGNT 540

Query: 541  RTKIGFITFDSTIHFYGLQESLSQPQMLIVSDIEDVFIPMPENLLVNLNESKELVQDLLK 600
            RTKIGFITFDSTIHFYGLQESLSQPQMLIVSDIEDVFIPMPENLLVNLNESKELVQDLLK
Sbjct: 541  RTKIGFITFDSTIHFYGLQESLSQPQMLIVSDIEDVFIPMPENLLVNLNESKELVQDLLK 600

Query: 601  TLPQMFTKTLETQSALGPALQAAFKLMSPTGGRMSVFQTQLPTLGVGALKPREEPNHRSS 660
            TLPQMFTKTLETQSALGPALQAAFKLMSPTGGRMSVFQTQLPTLGVGALKPREEPNHRSS
Sbjct: 601  TLPQMFTKTLETQSALGPALQAAFKLMSPTGGRMSVFQTQLPTLGVGALKPREEPNHRSS 660

Query: 661  AKDIHMTPSTDFYKKLALDCSGQQVAVDLFLLSGQYSDLASLGCISRYSAGSVYYYPSYH 720
            AKDIHMTPSTDFYKKLALDCSGQQVAVDLFLLSGQYSDLASLGCISRYSAGSVYYYPSYH
Sbjct: 661  AKDIHMTPSTDFYKKLALDCSGQQVAVDLFLLSGQYSDLASLGCISRYSAGSVYYYPSYH 720

Query: 721  HQHNPVQVQKLQKELQRYLTRKIGFEAVMRIRCTKGLSIHTFHGNFFVRSTDLLSLPNVN 780
            HQHNPVQVQKLQKELQRYLTRKIGFEAVMRIRCTKGLSIHTFHGNFFVRSTDLLSLPNVN
Sbjct: 721  HQHNPVQVQKLQKELQRYLTRKIGFEAVMRIRCTKGLSIHTFHGNFFVRSTDLLSLPNVN 780

Query: 781  PDAGYAVQMSVEESLTDTQLVSFQSALLYTSSKGERRIRVHTLCLPVVSTLNDVFLGADV 840
            PDAGYAVQMSVEESLTDTQLVSFQSALLYTSSKGERRIRVHTLCLPVVSTLNDVFLGADV
Sbjct: 781  PDAGYAVQMSVEESLTDTQLVSFQSALLYTSSKGERRIRVHTLCLPVVSTLNDVFLGADV 840

Query: 841  QAISGLLANMAVDRSMTASLSDARDALVNAVIDSLSAYRSSVLSNQQPGLMVPFSLRLFP 900
            QAISGLLANMAVDRSMTASLSDARDALVNAVIDSLSAYRSSVLSNQQPGLMVPFSLRLFP
Sbjct: 841  QAISGLLANMAVDRSMTASLSDARDALVNAVIDSLSAYRSSVLSNQQPGLMVPFSLRLFP 900

Query: 901  LFVLALLKQKSFQTGTNARLDERIFAMCQVKNQPLVYLMLTTHPSLYRVDNLSDEGALNI 960
            LFVLALLKQKSFQTGTNARLDERIFAMCQVKNQPLVYLMLTTHPSLYRVDNLSDEGALNI
Sbjct: 901  LFVLALLKQKSFQTGTNARLDERIFAMCQVKNQPLVYLMLTTHPSLYRVDNLSDEGALNI 960

Query: 961  SDRTIPQPPILQLSVEKLSRDGAFLMDAGSVLMLWVGKNCTQNFLSQVLGVQNYASIPQP 1020
            SDRTIPQPPILQLSVEKLSRDGAFLMDAGSVLMLWVGKNCTQNFLSQVLGVQNYASIPQP
Sbjct: 961  SDRTIPQPPILQLSVEKLSRDGAFLMDAGSVLMLWVGKNCTQNFLSQVLGVQNYASIPQP 1020

Query: 1021 MTDLPELDTPESARIIAFISWLREQRPFFPILYVIRDESPMKANFLQNMIEDRTESALSY 1080
            MTDLPELDTPESARIIAFISWLREQRPFFPILYVIRDESPMKANFLQNMIEDRTESALSY
Sbjct: 1021 MTDLPELDTPESARIIAFISWLREQRPFFPILYVIRDESPMKANFLQNMIEDRTESALSY 1080

Query: 1081 YEFLLHIQQQVNK 1093
            YEFLLHIQQQVNK
Sbjct: 1081 YEFLLHIQQQVNK 1093


>gi|112382214 SEC24 (S. cerevisiae) homolog B isoform b [Homo sapiens]
          Length = 1233

 Score = 1235 bits (3195), Expect = 0.0
 Identities = 663/1130 (58%), Positives = 814/1130 (72%), Gaps = 79/1130 (6%)

Query: 11   GAPASLQAQNGAALASGSPYTNGPVQNALLSSQESV-SQGYNFQLPGSYPHPIPAKTLNP 69
            GA +S    + +A    S + N     A+ S+  SV SQG+    P +  H   +   N 
Sbjct: 136  GAASSASHLHTSASQPYSSFVNHYNSPAMYSASSSVASQGF----PSTCGHYAMSTVSNA 191

Query: 70   VSGQSNY-----GGSQGSGQTLNRPPVASNPVTPSLHSG-------PAPRMPLPASQNPA 117
                 +Y     G + G   T    P    PV  +  SG       P+P  PLP+ Q+  
Sbjct: 192  AYPSVSYPSLPAGDTYGQMFTSQNAPTV-RPVKDNSFSGQNTAISHPSPLPPLPSQQHHQ 250

Query: 118  TTPMPSSSFLPEANLPPPLNWQYNYPSTASQTNHCPRASSQPTVSGNTSLTTNHQYVSSG 177
               +   S L  ++   P + Q N     + T     A++ PT++   SL+         
Sbjct: 251  QQSLSGYSTLTWSSPGLP-STQDNL--IRNHTGSLAVANNNPTITVADSLSC-------- 299

Query: 178  YPSLQNSFIKSGPSVPPLVNPPLPTTFQPGAPHGPPPAGGPPPVRALTPLTSSYRDVPQP 237
             P +QN      P   P+V+  L  +    +   PP A  P     + P+TS    V QP
Sbjct: 300  -PVMQNV---QPPKSSPVVSTVLSGSSGSSSTRTPPTANHP-----VEPVTS----VTQP 346

Query: 238  LFNSAVNQEGI-TSNTNNGSMVVHSSYDEIEGGGLLATPQLTNKNP-------------- 282
              +  + Q+G+ +S+T + +  + +SYD +EGG        +  +P              
Sbjct: 347  --SELLQQKGVDSSSTTSSASPMPNSYDALEGGSYPDMLSSSASSPAPDPAPEPDPASAP 404

Query: 283  --------------KMSRSVGYSYPSLPPGYQNTTPPGATGVPPSSLNYPSGPQAFTQTP 328
                          KM++  GY YP+L PGYQN T P  +GV PS+  Y SG Q + Q  
Sbjct: 405  APASAPAPVVPQPSKMAKPFGYGYPTLQPGYQNATAPLISGVQPSNPVY-SGFQQYPQQY 463

Query: 329  LGANHLTTSMSGLSLQ----PEGLRVVNLLQERNMLPSTPLKPPVPNLHEDIQKLNCNPE 384
             G N L++S+ GLSLQ    PE LR VNL QERN+LP TP+  PVPNL+ D++KLNC+P+
Sbjct: 464  PGVNQLSSSIGGLSLQSSPQPESLRPVNLTQERNILPMTPVWAPVPNLNADLKKLNCSPD 523

Query: 385  LFRCTLTSIPQTQALLNKAKLPLGLLLHPFKDLVQLPVVTSSTIVRCRSCRTYINPFVSF 444
             FRCTLT+IPQTQALLNKAKLPLGLLLHPF+DL QLPV+TS+TIVRCRSCRTYINPFVSF
Sbjct: 524  SFRCTLTNIPQTQALLNKAKLPLGLLLHPFRDLTQLPVITSNTIVRCRSCRTYINPFVSF 583

Query: 445  LDQRRWKCNLCYRVNDVPEEFLYNPLTRVYGEPHRRPEVQNATIEFMAPSEYMLRPPQPP 504
            +DQRRWKCNLCYRVNDVPEEF+YNPLTR YGEPH+RPEVQN+T+EF+A S+YMLRPPQP 
Sbjct: 584  IDQRRWKCNLCYRVNDVPEEFMYNPLTRSYGEPHKRPEVQNSTVEFIASSDYMLRPPQPA 643

Query: 505  VYLFVFDVSHNAVETGYLNSVCQSLLDNLDLLPGNTRTKIGFITFDSTIHFYGLQESLSQ 564
            VYLFV DVSHNAVE GYL  +CQSLL+NLD LPG++RT+IGF+TFDSTIHFY LQE LSQ
Sbjct: 644  VYLFVLDVSHNAVEAGYLTILCQSLLENLDKLPGDSRTRIGFMTFDSTIHFYNLQEGLSQ 703

Query: 565  PQMLIVSDIEDVFIPMPENLLVNLNESKELVQDLLKTLPQMFTKTLETQSALGPALQAAF 624
            PQMLIVSDI+DVF+P P++LLVNL ESKEL++DLL  LP MFT T ET SALGPALQAAF
Sbjct: 704  PQMLIVSDIDDVFLPTPDSLLVNLYESKELIKDLLNALPNMFTNTRETHSALGPALQAAF 763

Query: 625  KLMSPTGGRMSVFQTQLPTLGVGALKPREEPNHRSSAKDI-HMTPSTDFYKKLALDCSGQ 683
            KLMSPTGGR+SVFQTQLP+LG G L+ RE+PN RSS K + H+ P+TDFYKKLALDCSGQ
Sbjct: 764  KLMSPTGGRVSVFQTQLPSLGAGLLQSREDPNQRSSTKVVQHLGPATDFYKKLALDCSGQ 823

Query: 684  QVAVDLFLLSGQYSDLASLGCISRYSAGSVYYYPSYHHQHNPVQVQKLQKELQRYLTRKI 743
            Q AVDLFLLS QYSDLASL C+S+YSAG +YYYPS+H+ HNP Q +KLQK+L+RYLTRKI
Sbjct: 824  QTAVDLFLLSSQYSDLASLACMSKYSAGCIYYYPSFHYTHNPSQAEKLQKDLKRYLTRKI 883

Query: 744  GFEAVMRIRCTKGLSIHTFHGNFFVRSTDLLSLPNVNPDAGYAVQMSVEESLTDTQLVSF 803
            GFEAVMRIRCTKGLS+HTFHGNFFVRSTDLLSL N+NPDAG+AVQ+S+EESLTDT LV F
Sbjct: 884  GFEAVMRIRCTKGLSMHTFHGNFFVRSTDLLSLANINPDAGFAVQLSIEESLTDTSLVCF 943

Query: 804  QSALLYTSSKGERRIRVHTLCLPVVSTLNDVFLGADVQAISGLLANMAVDRSMTASLSDA 863
            Q+ALLYTSSKGERRIRVHTLCLPVVS+L DV+ G DVQA   LLANMAVDRS+++SLSDA
Sbjct: 944  QTALLYTSSKGERRIRVHTLCLPVVSSLADVYAGVDVQAAICLLANMAVDRSVSSSLSDA 1003

Query: 864  RDALVNAVIDSLSAYRSSVLSNQQPGLMVPFSLRLFPLFVLALLKQKSFQTGTNARLDER 923
            RDALVNAV+DSLSAY S+V + Q   LM P SL+LFPL+VLALLKQK+F+TGT+ RLD+R
Sbjct: 1004 RDALVNAVVDSLSAYGSTVSNLQHSALMAPSSLKLFPLYVLALLKQKAFRTGTSTRLDDR 1063

Query: 924  IFAMCQVKNQPLVYLMLTTHPSLYRVDNLSDEGALNISDRTIPQPPILQLSVEKLSRDGA 983
            ++AMCQ+K+QPLV+LM   HP+LYR+D L+DEGA++++DR +PQPP+ +LS EKL+R+GA
Sbjct: 1064 VYAMCQIKSQPLVHLMKMIHPNLYRIDRLTDEGAVHVNDRIVPQPPLQKLSAEKLTREGA 1123

Query: 984  FLMDAGSVLMLWVGKNCTQNFLSQVLGVQNYASIPQPMTDLPELDTPESARIIAFISWLR 1043
            FLMD GSV  +WVGK C  NF+  VLG  N+ASIPQ MT LPELDT  S R  +FI+WLR
Sbjct: 1124 FLMDCGSVFYIWVGKGCDNNFIEDVLGYTNFASIPQKMTHLPELDTLSSERARSFITWLR 1183

Query: 1044 EQRPFFPILYVIRDESPMKANFLQNMIEDRTESALSYYEFLLHIQQQVNK 1093
            + RP  PIL++++DESP KA F Q++IEDRTE+A SYYEFLLH+QQQ+ K
Sbjct: 1184 DSRPLSPILHIVKDESPAKAEFFQHLIEDRTEAAFSYYEFLLHVQQQICK 1233


>gi|112382212 SEC24 (S. cerevisiae) homolog B isoform a [Homo sapiens]
          Length = 1268

 Score = 1229 bits (3180), Expect = 0.0
 Identities = 663/1154 (57%), Positives = 818/1154 (70%), Gaps = 92/1154 (7%)

Query: 11   GAPASLQAQNGAALASGSPYTNGPVQNALLSSQESV-SQGYNFQLPGSYPHPIPAKTLNP 69
            GA +S    + +A    S + N     A+ S+  SV SQG+    P +  H   +   N 
Sbjct: 136  GAASSASHLHTSASQPYSSFVNHYNSPAMYSASSSVASQGF----PSTCGHYAMSTVSNA 191

Query: 70   VSGQSNY-----GGSQGSGQTLNRPPVASNPVTPSLHSG-------PAPRMPLPASQNPA 117
                 +Y     G + G   T    P    PV  +  SG       P+P  PLP+ Q+  
Sbjct: 192  AYPSVSYPSLPAGDTYGQMFTSQNAPTV-RPVKDNSFSGQNTAISHPSPLPPLPSQQHHQ 250

Query: 118  TTPMPSSSFLPEANLPPPLNWQYNYPSTASQTNHCPRASSQPTVSGNTSLTTNHQYVSSG 177
               +   S L  ++   P + Q N     + T     A++ PT++   SL+         
Sbjct: 251  QQSLSGYSTLTWSSPGLP-STQDNL--IRNHTGSLAVANNNPTITVADSLSC-------- 299

Query: 178  YPSLQNSFIKSGPSVPPLVNPPLPTTFQPGAPHGPPPAGGP-PPVRALTP---------- 226
             P +QN      P   P+V+  L  +    +   PP A  P  PV ++T           
Sbjct: 300  -PVMQNV---QPPKSSPVVSTVLSGSSGSSSTRTPPTANHPVEPVTSVTQPSELLQQKGV 355

Query: 227  -----LTSSYRDVPQPLFNSAVNQE--------GI-TSNTNNGSMVVHSSYDEIEGGGLL 272
                 + +     P PL +++ ++E        G+ +S+T + +  + +SYD +EGG   
Sbjct: 356  QYGEYVNNQASSAPTPLSSTSDDEEEEEEDEEAGVDSSSTTSSASPMPNSYDALEGGSYP 415

Query: 273  ATPQLTNKNP----------------------------KMSRSVGYSYPSLPPGYQNTTP 304
                 +  +P                            KM++  GY YP+L PGYQN T 
Sbjct: 416  DMLSSSASSPAPDPAPEPDPASAPAPASAPAPVVPQPSKMAKPFGYGYPTLQPGYQNATA 475

Query: 305  PGATGVPPSSLNYPSGPQAFTQTPLGANHLTTSMSGLSLQ----PEGLRVVNLLQERNML 360
            P  +GV PS+  Y SG Q + Q   G N L++S+ GLSLQ    PE LR VNL QERN+L
Sbjct: 476  PLISGVQPSNPVY-SGFQQYPQQYPGVNQLSSSIGGLSLQSSPQPESLRPVNLTQERNIL 534

Query: 361  PSTPLKPPVPNLHEDIQKLNCNPELFRCTLTSIPQTQALLNKAKLPLGLLLHPFKDLVQL 420
            P TP+  PVPNL+ D++KLNC+P+ FRCTLT+IPQTQALLNKAKLPLGLLLHPF+DL QL
Sbjct: 535  PMTPVWAPVPNLNADLKKLNCSPDSFRCTLTNIPQTQALLNKAKLPLGLLLHPFRDLTQL 594

Query: 421  PVVTSSTIVRCRSCRTYINPFVSFLDQRRWKCNLCYRVNDVPEEFLYNPLTRVYGEPHRR 480
            PV+TS+TIVRCRSCRTYINPFVSF+DQRRWKCNLCYRVNDVPEEF+YNPLTR YGEPH+R
Sbjct: 595  PVITSNTIVRCRSCRTYINPFVSFIDQRRWKCNLCYRVNDVPEEFMYNPLTRSYGEPHKR 654

Query: 481  PEVQNATIEFMAPSEYMLRPPQPPVYLFVFDVSHNAVETGYLNSVCQSLLDNLDLLPGNT 540
            PEVQN+T+EF+A S+YMLRPPQP VYLFV DVSHNAVE GYL  +CQSLL+NLD LPG++
Sbjct: 655  PEVQNSTVEFIASSDYMLRPPQPAVYLFVLDVSHNAVEAGYLTILCQSLLENLDKLPGDS 714

Query: 541  RTKIGFITFDSTIHFYGLQESLSQPQMLIVSDIEDVFIPMPENLLVNLNESKELVQDLLK 600
            RT+IGF+TFDSTIHFY LQE LSQPQMLIVSDI+DVF+P P++LLVNL ESKEL++DLL 
Sbjct: 715  RTRIGFMTFDSTIHFYNLQEGLSQPQMLIVSDIDDVFLPTPDSLLVNLYESKELIKDLLN 774

Query: 601  TLPQMFTKTLETQSALGPALQAAFKLMSPTGGRMSVFQTQLPTLGVGALKPREEPNHRSS 660
             LP MFT T ET SALGPALQAAFKLMSPTGGR+SVFQTQLP+LG G L+ RE+PN RSS
Sbjct: 775  ALPNMFTNTRETHSALGPALQAAFKLMSPTGGRVSVFQTQLPSLGAGLLQSREDPNQRSS 834

Query: 661  AKDI-HMTPSTDFYKKLALDCSGQQVAVDLFLLSGQYSDLASLGCISRYSAGSVYYYPSY 719
             K + H+ P+TDFYKKLALDCSGQQ AVDLFLLS QYSDLASL C+S+YSAG +YYYPS+
Sbjct: 835  TKVVQHLGPATDFYKKLALDCSGQQTAVDLFLLSSQYSDLASLACMSKYSAGCIYYYPSF 894

Query: 720  HHQHNPVQVQKLQKELQRYLTRKIGFEAVMRIRCTKGLSIHTFHGNFFVRSTDLLSLPNV 779
            H+ HNP Q +KLQK+L+RYLTRKIGFEAVMRIRCTKGLS+HTFHGNFFVRSTDLLSL N+
Sbjct: 895  HYTHNPSQAEKLQKDLKRYLTRKIGFEAVMRIRCTKGLSMHTFHGNFFVRSTDLLSLANI 954

Query: 780  NPDAGYAVQMSVEESLTDTQLVSFQSALLYTSSKGERRIRVHTLCLPVVSTLNDVFLGAD 839
            NPDAG+AVQ+S+EESLTDT LV FQ+ALLYTSSKGERRIRVHTLCLPVVS+L DV+ G D
Sbjct: 955  NPDAGFAVQLSIEESLTDTSLVCFQTALLYTSSKGERRIRVHTLCLPVVSSLADVYAGVD 1014

Query: 840  VQAISGLLANMAVDRSMTASLSDARDALVNAVIDSLSAYRSSVLSNQQPGLMVPFSLRLF 899
            VQA   LLANMAVDRS+++SLSDARDALVNAV+DSLSAY S+V + Q   LM P SL+LF
Sbjct: 1015 VQAAICLLANMAVDRSVSSSLSDARDALVNAVVDSLSAYGSTVSNLQHSALMAPSSLKLF 1074

Query: 900  PLFVLALLKQKSFQTGTNARLDERIFAMCQVKNQPLVYLMLTTHPSLYRVDNLSDEGALN 959
            PL+VLALLKQK+F+TGT+ RLD+R++AMCQ+K+QPLV+LM   HP+LYR+D L+DEGA++
Sbjct: 1075 PLYVLALLKQKAFRTGTSTRLDDRVYAMCQIKSQPLVHLMKMIHPNLYRIDRLTDEGAVH 1134

Query: 960  ISDRTIPQPPILQLSVEKLSRDGAFLMDAGSVLMLWVGKNCTQNFLSQVLGVQNYASIPQ 1019
            ++DR +PQPP+ +LS EKL+R+GAFLMD GSV  +WVGK C  NF+  VLG  N+ASIPQ
Sbjct: 1135 VNDRIVPQPPLQKLSAEKLTREGAFLMDCGSVFYIWVGKGCDNNFIEDVLGYTNFASIPQ 1194

Query: 1020 PMTDLPELDTPESARIIAFISWLREQRPFFPILYVIRDESPMKANFLQNMIEDRTESALS 1079
             MT LPELDT  S R  +FI+WLR+ RP  PIL++++DESP KA F Q++IEDRTE+A S
Sbjct: 1195 KMTHLPELDTLSSERARSFITWLRDSRPLSPILHIVKDESPAKAEFFQHLIEDRTEAAFS 1254

Query: 1080 YYEFLLHIQQQVNK 1093
            YYEFLLH+QQQ+ K
Sbjct: 1255 YYEFLLHVQQQICK 1268


>gi|38373671 SEC24-related protein C [Homo sapiens]
          Length = 1094

 Score =  395 bits (1015), Expect = e-109
 Identities = 312/1130 (27%), Positives = 510/1130 (45%), Gaps = 144/1130 (12%)

Query: 7    PASGGAPASLQAQNGAALASGSPYTNGPVQNALLSSQESVSQGYNFQLPGSYPHPIPAKT 66
            P S GAP +  AQ     A+   +  G VQN   S+ +        +LPGS P   P   
Sbjct: 63   PPSSGAPPASTAQAPCGQAAYGQFGQGDVQNGPSSTVQMQ------RLPGSQPFGSP--- 113

Query: 67   LNPVSGQ----SNYGGSQGSGQTLNR-------PPVASNPVTPSLHSGPAPRMPLPASQN 115
            L PV  Q      YG    S Q   +         VA  P +  L  GP      P S  
Sbjct: 114  LAPVGNQPPVLQPYGPPPTSAQVATQLSGMQISGAVAPAPPSSGLGFGP------PTSLA 167

Query: 116  PATTPMPSSSFL---PEANLPPPLNWQYNYPSTASQTNHCPRASSQ--PTVSGNTSLTTN 170
             A+   P+S      P+   PP L+    +P   +     P  +S   P  SG       
Sbjct: 168  SASGSFPNSGLYGSYPQGQAPP-LSQAQGHPGIQTPQRSAPSQASSFTPPASG------- 219

Query: 171  HQYVSSGYPSLQNSFIKSGPSVPPLVNPPLPTTFQPGAPHGPPPAGGPPPVRALTPLTSS 230
                              GP +P +  P LP     G     P     PP +AL P T  
Sbjct: 220  ------------------GPRLPSMTGPLLPGQSFGGPSVSQPNHVSSPP-QALPPGTQM 260

Query: 231  YRDV-PQPLFNSAVNQEGITSNTNNGSMVVHSSYDEIEGGGLLATPQLTNKNPKMSRSVG 289
               + P P  +S   Q+       NGS             G    PQ     P       
Sbjct: 261  TGPLGPLPPMHSP--QQPGYQPQQNGSF------------GPARGPQSNYGGP------- 299

Query: 290  YSYPSLPPGYQNTTPPGATGVPPSSLNYPSGPQAFTQTPLGANHLTTS--MSGLSLQPEG 347
              YP+ P       PP    +PP  L+  + P          N+  T   ++G+  Q   
Sbjct: 300  --YPAAPTFGSQPGPPQP--LPPKRLDPDAIPSPIQVIEDDRNNRGTEPFVTGVRGQVPP 355

Query: 348  LRVVNLLQERNMLPSTPLKPPVPNLHEDIQKLNCNPELFRCTLTSIPQTQALLNKAKLPL 407
            L   N L +                     + N +P   RCT  +IP T  +  +A++PL
Sbjct: 356  LVTTNFLVK--------------------DQGNASPRYIRCTSYNIPCTSDMAKQAQVPL 395

Query: 408  GLLLHPFKDLVQLPVVTSSTIV---------RCRSCRTYINPFVSFLDQ-RRWKCNLCYR 457
              ++ P   L +LP   +S  V         RC  C+ Y+ PF+ F++  RR++C  C  
Sbjct: 396  AAVIKP---LARLPPEEASPYVVDHGESGPLRCNRCKAYMCPFMQFIEGGRRFQCCFCSC 452

Query: 458  VNDVPEEFLYN-PLTRVYGEPHRRPEVQNATIEFMAPSEYMLRP--PQPPVYLFVFDVSH 514
            +NDVP ++  +   T    + + RPE+   + EF+A  +Y      P PP ++F+ DVS+
Sbjct: 453  INDVPPQYFQHLDHTGKRVDAYDRPELSLGSYEFLATVDYCKNNKFPSPPAFIFMIDVSY 512

Query: 515  NAVETGYLNSVCQSLLDNLDLLPGN-----TRTKIGFITFDSTIHFYGLQESLSQPQMLI 569
            NA+ TG +  +C+ L   LD LP       +  ++GF+T++  +HFY ++ SL+QPQM++
Sbjct: 513  NAIRTGLVRLLCEELKSLLDFLPREGGAEESAIRVGFVTYNKVLHFYNVKSSLAQPQMMV 572

Query: 570  VSDIEDVFIPMPENLLVNLNESKELVQDLLKTLPQMFTKTLETQSALGPALQAAFKLM-- 627
            VSD+ D+F+P+ +  LVN+NES+ ++  LL  +P+MF  T ET++   P +QA  + +  
Sbjct: 573  VSDVADMFVPLLDGFLVNVNESRAVITSLLDQIPEMFADTRETETVFVPVIQAGMEALKA 632

Query: 628  SPTGGRMSVFQTQLPTL-GVGALKPREEPNHRSSAKDIHM-TPSTDFYKKLALDCSGQQV 685
            +   G++ +F T LP     G LK R++    ++ K+  +  P T  Y+ LA +C  Q  
Sbjct: 633  AECAGKLFLFHTSLPIAEAPGKLKNRDDRKLINTDKEKTLFQPQTGAYQTLAKECVAQGC 692

Query: 686  AVDLFLLSGQYSDLASLGCISRYSAGSVYYYPSYHHQHNPVQVQKLQKELQRYLTRKIGF 745
             VDLFL   QY D+A+L  + + + GSVY Y S+  +++    ++   +L+R + + +GF
Sbjct: 693  CVDLFLFPNQYVDVATLSVVPQLTGGSVYKYASFQVENDQ---ERFLSDLRRDVQKVVGF 749

Query: 746  EAVMRIRCTKGLSIHTFHGNFFVRSTDLLSLPNVNPDAGYAVQMSVEESLTDTQLVSFQS 805
            +AVMR+R + G+    F G F++ +T  + L  ++ D    V+   ++ L +      Q 
Sbjct: 750  DAVMRVRTSTGIRAVDFFGAFYMSNTTDVELAGLDGDKTVTVEFKHDDRLNEESGALLQC 809

Query: 806  ALLYTSSKGERRIRVHTLCLPVVSTLNDVFLGADVQAISGLLANMAVDRSMTASLSDARD 865
            ALLYTS  G+RR+R+H L L   + L D++   +   +   +A  A    + + +   RD
Sbjct: 810  ALLYTSCAGQRRLRIHNLALNCCTQLADLYRNCETDTLINYMAKFAYRGVLNSPVKAVRD 869

Query: 866  ALVNAVIDSLSAYRSSVLSNQQPG-LMVPFSLRLFPLFVLALLKQKSFQTGTNARLDERI 924
             L+      L+ YR +  S    G L++P  ++L P+++  +LK    Q G     D+R 
Sbjct: 870  TLITQCAQILACYRKNCASPSSAGQLILPECMKLLPVYLNCVLKSDVLQPGAEVTTDDRA 929

Query: 925  FAMCQVKNQPLVYLMLTTHPSLYRVDNLSDEGALNISDRTIPQPPILQLSVEKLSRDGAF 984
            +    V +  +    +  +P L  +     E        +  +PP ++ S E+LS    +
Sbjct: 930  YVRQLVTSMDVTETNVFFYPRLLPLTKSPVE--------STTEPPAVRASEERLSNGDIY 981

Query: 985  LMDAGSVLMLWVGKNCTQNFLSQVLGVQNYASIPQPMTDLPELDTPESARIIAFISWLRE 1044
            L++ G  L LWVG +  Q  +  +  V +++ I   ++ LP LD P S ++   I  LR 
Sbjct: 982  LLENGLNLFLWVGASVQQGVVQSLFSVSSFSQITSGLSVLPVLDNPLSKKVRGLIDSLRA 1041

Query: 1045 QRPFFPILYVIRDESPMKANFLQNMIEDRTES-ALSYYEFLLHIQQQVNK 1093
            QR  +  L V++ E  M+  F   ++ED++ S   SY +FL H+ +++ +
Sbjct: 1042 QRSRYMKLTVVKQEDKMEMLFKHFLVEDKSLSGGASYVDFLCHMHKEIRQ 1091



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 52/171 (30%), Positives = 71/171 (41%), Gaps = 26/171 (15%)

Query: 4   PGIPASG---GAPASLQAQNGAALASG--SPYTNG---PVQNA-----LLSSQESV-SQG 49
           P  P+SG   G P SL + +G+   SG    Y  G   P+  A     + + Q S  SQ 
Sbjct: 151 PAPPSSGLGFGPPTSLASASGSFPNSGLYGSYPQGQAPPLSQAQGHPGIQTPQRSAPSQA 210

Query: 50  YNFQLPGSYPHPIPAKTLNPVSGQSNYGGSQGSGQTLNRPPVASNPVTPSLHSGP-APRM 108
            +F  P S    +P+ T   + GQS  G S      ++ PP A  P T    +GP  P  
Sbjct: 211 SSFTPPASGGPRLPSMTGPLLPGQSFGGPSVSQPNHVSSPPQALPPGTQM--TGPLGPLP 268

Query: 109 PLPASQNPATTPMPSSSFLPEANLPPPLNWQYNYPSTASQTNHCPRASSQP 159
           P+ + Q P   P  + SF P     P  N+   YP+        P   SQP
Sbjct: 269 PMHSPQQPGYQPQQNGSFGPARG--PQSNYGGPYPA-------APTFGSQP 310


>gi|38373669 SEC24-related protein C [Homo sapiens]
          Length = 1094

 Score =  395 bits (1015), Expect = e-109
 Identities = 312/1130 (27%), Positives = 510/1130 (45%), Gaps = 144/1130 (12%)

Query: 7    PASGGAPASLQAQNGAALASGSPYTNGPVQNALLSSQESVSQGYNFQLPGSYPHPIPAKT 66
            P S GAP +  AQ     A+   +  G VQN   S+ +        +LPGS P   P   
Sbjct: 63   PPSSGAPPASTAQAPCGQAAYGQFGQGDVQNGPSSTVQMQ------RLPGSQPFGSP--- 113

Query: 67   LNPVSGQ----SNYGGSQGSGQTLNR-------PPVASNPVTPSLHSGPAPRMPLPASQN 115
            L PV  Q      YG    S Q   +         VA  P +  L  GP      P S  
Sbjct: 114  LAPVGNQPPVLQPYGPPPTSAQVATQLSGMQISGAVAPAPPSSGLGFGP------PTSLA 167

Query: 116  PATTPMPSSSFL---PEANLPPPLNWQYNYPSTASQTNHCPRASSQ--PTVSGNTSLTTN 170
             A+   P+S      P+   PP L+    +P   +     P  +S   P  SG       
Sbjct: 168  SASGSFPNSGLYGSYPQGQAPP-LSQAQGHPGIQTPQRSAPSQASSFTPPASG------- 219

Query: 171  HQYVSSGYPSLQNSFIKSGPSVPPLVNPPLPTTFQPGAPHGPPPAGGPPPVRALTPLTSS 230
                              GP +P +  P LP     G     P     PP +AL P T  
Sbjct: 220  ------------------GPRLPSMTGPLLPGQSFGGPSVSQPNHVSSPP-QALPPGTQM 260

Query: 231  YRDV-PQPLFNSAVNQEGITSNTNNGSMVVHSSYDEIEGGGLLATPQLTNKNPKMSRSVG 289
               + P P  +S   Q+       NGS             G    PQ     P       
Sbjct: 261  TGPLGPLPPMHSP--QQPGYQPQQNGSF------------GPARGPQSNYGGP------- 299

Query: 290  YSYPSLPPGYQNTTPPGATGVPPSSLNYPSGPQAFTQTPLGANHLTTS--MSGLSLQPEG 347
              YP+ P       PP    +PP  L+  + P          N+  T   ++G+  Q   
Sbjct: 300  --YPAAPTFGSQPGPPQP--LPPKRLDPDAIPSPIQVIEDDRNNRGTEPFVTGVRGQVPP 355

Query: 348  LRVVNLLQERNMLPSTPLKPPVPNLHEDIQKLNCNPELFRCTLTSIPQTQALLNKAKLPL 407
            L   N L +                     + N +P   RCT  +IP T  +  +A++PL
Sbjct: 356  LVTTNFLVK--------------------DQGNASPRYIRCTSYNIPCTSDMAKQAQVPL 395

Query: 408  GLLLHPFKDLVQLPVVTSSTIV---------RCRSCRTYINPFVSFLDQ-RRWKCNLCYR 457
              ++ P   L +LP   +S  V         RC  C+ Y+ PF+ F++  RR++C  C  
Sbjct: 396  AAVIKP---LARLPPEEASPYVVDHGESGPLRCNRCKAYMCPFMQFIEGGRRFQCCFCSC 452

Query: 458  VNDVPEEFLYN-PLTRVYGEPHRRPEVQNATIEFMAPSEYMLRP--PQPPVYLFVFDVSH 514
            +NDVP ++  +   T    + + RPE+   + EF+A  +Y      P PP ++F+ DVS+
Sbjct: 453  INDVPPQYFQHLDHTGKRVDAYDRPELSLGSYEFLATVDYCKNNKFPSPPAFIFMIDVSY 512

Query: 515  NAVETGYLNSVCQSLLDNLDLLPGN-----TRTKIGFITFDSTIHFYGLQESLSQPQMLI 569
            NA+ TG +  +C+ L   LD LP       +  ++GF+T++  +HFY ++ SL+QPQM++
Sbjct: 513  NAIRTGLVRLLCEELKSLLDFLPREGGAEESAIRVGFVTYNKVLHFYNVKSSLAQPQMMV 572

Query: 570  VSDIEDVFIPMPENLLVNLNESKELVQDLLKTLPQMFTKTLETQSALGPALQAAFKLM-- 627
            VSD+ D+F+P+ +  LVN+NES+ ++  LL  +P+MF  T ET++   P +QA  + +  
Sbjct: 573  VSDVADMFVPLLDGFLVNVNESRAVITSLLDQIPEMFADTRETETVFVPVIQAGMEALKA 632

Query: 628  SPTGGRMSVFQTQLPTL-GVGALKPREEPNHRSSAKDIHM-TPSTDFYKKLALDCSGQQV 685
            +   G++ +F T LP     G LK R++    ++ K+  +  P T  Y+ LA +C  Q  
Sbjct: 633  AECAGKLFLFHTSLPIAEAPGKLKNRDDRKLINTDKEKTLFQPQTGAYQTLAKECVAQGC 692

Query: 686  AVDLFLLSGQYSDLASLGCISRYSAGSVYYYPSYHHQHNPVQVQKLQKELQRYLTRKIGF 745
             VDLFL   QY D+A+L  + + + GSVY Y S+  +++    ++   +L+R + + +GF
Sbjct: 693  CVDLFLFPNQYVDVATLSVVPQLTGGSVYKYASFQVENDQ---ERFLSDLRRDVQKVVGF 749

Query: 746  EAVMRIRCTKGLSIHTFHGNFFVRSTDLLSLPNVNPDAGYAVQMSVEESLTDTQLVSFQS 805
            +AVMR+R + G+    F G F++ +T  + L  ++ D    V+   ++ L +      Q 
Sbjct: 750  DAVMRVRTSTGIRAVDFFGAFYMSNTTDVELAGLDGDKTVTVEFKHDDRLNEESGALLQC 809

Query: 806  ALLYTSSKGERRIRVHTLCLPVVSTLNDVFLGADVQAISGLLANMAVDRSMTASLSDARD 865
            ALLYTS  G+RR+R+H L L   + L D++   +   +   +A  A    + + +   RD
Sbjct: 810  ALLYTSCAGQRRLRIHNLALNCCTQLADLYRNCETDTLINYMAKFAYRGVLNSPVKAVRD 869

Query: 866  ALVNAVIDSLSAYRSSVLSNQQPG-LMVPFSLRLFPLFVLALLKQKSFQTGTNARLDERI 924
             L+      L+ YR +  S    G L++P  ++L P+++  +LK    Q G     D+R 
Sbjct: 870  TLITQCAQILACYRKNCASPSSAGQLILPECMKLLPVYLNCVLKSDVLQPGAEVTTDDRA 929

Query: 925  FAMCQVKNQPLVYLMLTTHPSLYRVDNLSDEGALNISDRTIPQPPILQLSVEKLSRDGAF 984
            +    V +  +    +  +P L  +     E        +  +PP ++ S E+LS    +
Sbjct: 930  YVRQLVTSMDVTETNVFFYPRLLPLTKSPVE--------STTEPPAVRASEERLSNGDIY 981

Query: 985  LMDAGSVLMLWVGKNCTQNFLSQVLGVQNYASIPQPMTDLPELDTPESARIIAFISWLRE 1044
            L++ G  L LWVG +  Q  +  +  V +++ I   ++ LP LD P S ++   I  LR 
Sbjct: 982  LLENGLNLFLWVGASVQQGVVQSLFSVSSFSQITSGLSVLPVLDNPLSKKVRGLIDSLRA 1041

Query: 1045 QRPFFPILYVIRDESPMKANFLQNMIEDRTES-ALSYYEFLLHIQQQVNK 1093
            QR  +  L V++ E  M+  F   ++ED++ S   SY +FL H+ +++ +
Sbjct: 1042 QRSRYMKLTVVKQEDKMEMLFKHFLVEDKSLSGGASYVDFLCHMHKEIRQ 1091



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 52/171 (30%), Positives = 71/171 (41%), Gaps = 26/171 (15%)

Query: 4   PGIPASG---GAPASLQAQNGAALASG--SPYTNG---PVQNA-----LLSSQESV-SQG 49
           P  P+SG   G P SL + +G+   SG    Y  G   P+  A     + + Q S  SQ 
Sbjct: 151 PAPPSSGLGFGPPTSLASASGSFPNSGLYGSYPQGQAPPLSQAQGHPGIQTPQRSAPSQA 210

Query: 50  YNFQLPGSYPHPIPAKTLNPVSGQSNYGGSQGSGQTLNRPPVASNPVTPSLHSGP-APRM 108
            +F  P S    +P+ T   + GQS  G S      ++ PP A  P T    +GP  P  
Sbjct: 211 SSFTPPASGGPRLPSMTGPLLPGQSFGGPSVSQPNHVSSPPQALPPGTQM--TGPLGPLP 268

Query: 109 PLPASQNPATTPMPSSSFLPEANLPPPLNWQYNYPSTASQTNHCPRASSQP 159
           P+ + Q P   P  + SF P     P  N+   YP+        P   SQP
Sbjct: 269 PMHSPQQPGYQPQQNGSFGPARG--PQSNYGGPYPA-------APTFGSQP 310


>gi|190343021 Sec24-related protein D [Homo sapiens]
          Length = 1032

 Score =  357 bits (917), Expect = 3e-98
 Identities = 258/983 (26%), Positives = 453/983 (46%), Gaps = 95/983 (9%)

Query: 192  VPPLVNPPLPTTFQPGAPH--GPPPAG--GPPPVRALTPLTSSYRDVPQPLFNSAVNQEG 247
            +PP   PP P  F     H  G PP    GPPPV  +    + Y+   Q  +   ++   
Sbjct: 57   LPPGPPPPGPHQFGQNGAHATGHPPQRFPGPPPVNNVASSHAPYQPSAQSSYPGPISTSS 116

Query: 248  ITSNTNNGSMVVHSSY-------DEIEGGGLLATPQLTNKNPKMSRSVGYSYPSLPPGYQ 300
            +T   +  S +  +SY        +   G L AT   T   P     +      LPP   
Sbjct: 117  VTQLGSQLSAMQINSYGSGMAPPSQGPPGPLSATSLQTPPRPPQPSILQPGSQVLPPPPT 176

Query: 301  NTTPPGATGVP-----PSSLNYPSGPQAFTQTP------LGANHLTTS------MSGLSL 343
                PGA+ +P     P  L+ P  P A  Q P      LGA +          M+G  L
Sbjct: 177  TLNGPGASPLPLPMYRPDGLSGPPPPNAQYQPPPLPGQTLGAGYPPQQANSGPQMAGAQL 236

Query: 344  QPEG------LRVVNLLQERNMLPSTPLKPPVPNLHED---------------------- 375
               G       ++    Q +  L    +  P+  +  D                      
Sbjct: 237  SYPGGFPGGPAQMAGPPQPQKKLDPDSIPSPIQVIENDRASRGGQVYATNTRGQIPPLVT 296

Query: 376  ----IQKL-NCNPELFRCTLTSIPQTQALLNKAKLPLGLLLHPFKDL------VQLPVVT 424
                IQ   N +P   RCT    P T  +  +A++PL  ++ PF  +      + L    
Sbjct: 297  TDCMIQDQGNASPRFIRCTTYCFPCTSDMAKQAQIPLAAVIKPFATIPSNESPLYLVNHG 356

Query: 425  SSTIVRCRSCRTYINPFVSFLDQ-RRWKCNLCYRVNDVPEEFLYNPLTRVYG--EPHRRP 481
             S  VRC  C+ Y+ PF+ F++  RR++C  C  VNDVP  F +  L  +    + + +P
Sbjct: 357  ESGPVRCNRCKAYMCPFMQFIEGGRRYQCGFCNCVNDVPP-FYFQHLDHIGRRLDHYEKP 415

Query: 482  EVQNATIEFMAPSEYMLR--PPQPPVYLFVFDVSHNAVETGYLNSVCQSLLDNLDLLPGN 539
            E+   + E++A  +Y  +  PP PP ++F+ DVS++ ++ G +  +C+ L   L+ +P  
Sbjct: 416  ELSLGSYEYVATLDYCRKSKPPNPPAFIFMIDVSYSNIKNGLVKLICEELKTMLEKIPKE 475

Query: 540  TRT-----KIGFITFDSTIHFYGLQESLSQPQMLIVSDIEDVFIPMPENLLVNLNESKEL 594
             +      ++GFIT++  +HF+ ++ +L+QPQM++V+D+ +VF+P+ +  LVN  ES+ +
Sbjct: 476  EQEETSAIRVGFITYNKVLHFFNVKSNLAQPQMMVVTDVGEVFVPLLDGFLVNYQESQSV 535

Query: 595  VQDLLKTLPQMFTKTLETQSALGPALQAAFKLMSPTG--GRMSVFQTQLPTLGV-GALKP 651
            + +LL  +P MF  + E ++   P +QA  + +      G++ +F + LPT    G LK 
Sbjct: 536  IHNLLDQIPDMFADSNENETVFAPVIQAGMEALKAADCPGKLFIFHSSLPTAEAPGKLKN 595

Query: 652  REEPNHRSSAKD-IHMTPSTDFYKKLALDCSGQQVAVDLFLLSGQYSDLASLGCISRYSA 710
            R++    ++ K+ I   P T+ Y  LA DC     +V LFL   QY D+ASLG + + + 
Sbjct: 596  RDDKKLVNTDKEKILFQPQTNVYDSLAKDCVAHGCSVTLFLFPSQYVDVASLGLVPQLTG 655

Query: 711  GSVYYYPSYHHQHNPVQVQKLQKELQRYLTRKIGFEAVMRIRCTKGLSIHTFHGNFFVRS 770
            G++Y Y ++      +  Q+   +L+  + +KIGF+A+MR+R + G     F G   + +
Sbjct: 656  GTLYKYNNFQMH---LDRQQFLNDLRNDIEKKIGFDAIMRVRTSTGFRATDFFGGILMNN 712

Query: 771  TDLLSLPNVNPDAGYAVQMSVEESLTDTQLVSFQSALLYTSSKGERRIRVHTLCLPVVST 830
            T  + +  ++ D    V+   ++ L++      Q A+LYT+  G+RR+R+H L L   S 
Sbjct: 713  TTDVEMAAIDCDKAVTVEFKHDDKLSEDSGALIQCAVLYTTISGQRRLRIHNLGLNCSSQ 772

Query: 831  LNDVFLGADVQAISGLLANMAVDRSMTASLSDARDALVNAVIDSLSAYRSSVLS-NQQPG 889
            L D++   +  A+    A  A    +   L   R+ LVN     L+ YR +  S +    
Sbjct: 773  LADLYKSCETDALINFFAKSAFKAVLHQPLKVIREILVNQTAHMLACYRKNCASPSAASQ 832

Query: 890  LMVPFSLRLFPLFVLALLKQKSFQTGTNARLDERIFAMCQVKNQPLVYLMLTTHPSLYRV 949
            L++P S+++ P+++  LLK     +      DER +    V    +    L  +P L  +
Sbjct: 833  LILPDSMKVLPVYMNCLLKNCVLLSRPEISTDERAYQRQLVMTMGVADSQLFFYPQLLPI 892

Query: 950  DNLSDEGALNISDRTIPQPPILQLSVEKLSRDGAFLMDAGSVLMLWVGKNCTQNFLSQVL 1009
              L  +  +         P  ++ S  +LS +G FL+  G  + LW+G +     +  + 
Sbjct: 893  HTLDVKSTM--------LPAAVRCSESRLSEEGIFLLANGLHMFLWLGVSSPPELIQGIF 944

Query: 1010 GVQNYASIPQPMTDLPELDTPESARIIAFISWLREQRPFFPILYVIRDESPMKANFLQNM 1069
             V ++A I   MT LPE+  P S ++   +  ++++RP+   L +++     +  F Q +
Sbjct: 945  NVPSFAHINTDMTLLPEVGNPYSQQLRMIMGIIQQKRPYSMKLTIVKQREQPEMVFRQFL 1004

Query: 1070 IEDR-TESALSYYEFLLHIQQQV 1091
            +ED+      SY +FL  + +++
Sbjct: 1005 VEDKGLYGGSSYVDFLCCVHKEI 1027


>gi|14591924 Sec23 homolog B [Homo sapiens]
          Length = 767

 Score = 75.1 bits (183), Expect = 3e-13
 Identities = 147/681 (21%), Positives = 255/681 (37%), Gaps = 109/681 (16%)

Query: 394  PQTQALLNKAKLPLGLLLHPFKDLVQLPVVTSSTIVRCR-SCRTYINPFVSFLDQRR--W 450
            P ++    +  +PL  LL P K+   LP V    ++  R +C+  +NP    +D R   W
Sbjct: 25   PSSRLEATRMVVPLACLLTPLKERPDLPPVQYEPVLCSRPTCKAVLNPLCQ-VDYRAKLW 83

Query: 451  KCNLCYRVNDVPEEFLYNPLTRVYGEPHRRPEVQNATIEFMAPSEYMLRPPQPP-VYLFV 509
             CN C++ N  P    Y  ++ V       P  Q +TIE++     + R  Q P ++L+V
Sbjct: 84   ACNFCFQRNQFPP--AYGGISEVNQPAELMP--QFSTIEYV-----IQRGAQSPLIFLYV 134

Query: 510  FDVSHNAVETGYLNSVCQSLLDNLDLLPGNTRTKIGFITFDSTIHFYGLQ-ESLSQPQM- 567
             D     +E   L ++ +SL  +L LLP +    +G ITF   +  + L  E +S+  + 
Sbjct: 135  VD---TCLEEDDLQALKESLQMSLSLLPPD--ALVGLITFGRMVQVHELSCEGISKSYVF 189

Query: 568  -----LIVSDIEDVF------IPMPE--------------NLLVNLNESKELVQDLLKTL 602
                 L    I+D+       +PM +                L  +++    + DLL  L
Sbjct: 190  RGTKDLTAKQIQDMLGLTKPAMPMQQARPAQPQEHPFASSRFLQPVHKIDMNLTDLLGEL 249

Query: 603  ---PQMFTKTLETQSALGPALQAAFKLMS----PTGGRMSVFQTQLPTLGVGALKPREEP 655
               P   T+      + G AL  A  L+      TG R+ +F    PT G G +   E  
Sbjct: 250  QRDPWPVTQGKRPLRSTGVALSIAVGLLEGTFPNTGARIMLFTGGPPTQGPGMVVGDELK 309

Query: 656  NHRSSAKDIH------MTPSTDFYKKLALDCSGQQVAVDLFLLSGQYSDLASLGCISRYS 709
                S  DI       M  +T  Y+ LA   +     +D++  +   + L  + C +  +
Sbjct: 310  IPIRSWHDIEKDNARFMKKATKHYEMLANRTAANGHCIDIYACALDQTGLLEMKCCANLT 369

Query: 710  AGSVYYYPSYHHQHNPVQVQKLQKELQRYLTR------KIGFEAVMRIRCTKGLSIHTFH 763
             G +    S++           ++  QR  T+      ++ F A + ++ ++ L I    
Sbjct: 370  GGYMVMGDSFN-------TSLFKQTFQRIFTKDFNGDFRMAFGATLDVKTSRELKIAGAI 422

Query: 764  G---------------NFFVRSTDLLSLPNVNPDAGYAVQMSV----EESLTDTQLVSFQ 804
            G                  V  T    +  ++P +   +   V       +      + Q
Sbjct: 423  GPCVSLNVKGPCVSENELGVGGTSQWKICGLDPTSTLGIYFEVVNQHNTPIPQGGRGAIQ 482

Query: 805  SALLYTSSKGERRIRVHTLC---LPVVSTLNDVFLGADVQAISGLLANMAVDRSMTASLS 861
                Y  S  +RRIRV T+      V S L  +    D +A + L+A + V R+ +    
Sbjct: 483  FVTHYQHSSTQRRIRVTTIARNWADVQSQLRHIEAAFDQEAAAVLMARLGVFRAESEEGP 542

Query: 862  DARDALVNAVIDSLSAYRSSVLSNQQPGLMVPFSLRLFPLFVLALLKQKSFQTGTNARLD 921
            D    L   +I     +             +  S  L+P F+  L +    Q   N+  D
Sbjct: 543  DVLRWLDRQLIRLCQKF-GQYNKEDPTSFRLSDSFSLYPQFMFHLRRSPFLQVFNNSP-D 600

Query: 922  ERIFAMCQVKNQPLVYLMLTTHPSLYRVDNLSDEGALNISDRTIPQPPILQLSVEKLSRD 981
            E  +       Q L   ++   P LY           + S    P+P +L  S   +  D
Sbjct: 601  ESSYYRHHFARQDLTQSLIMIQPILY-----------SYSFHGPPEPVLLDSS--SILAD 647

Query: 982  GAFLMDAGSVLMLWVGKNCTQ 1002
               LMD    +++++G+   Q
Sbjct: 648  RILLMDTFFQIVIYLGETIAQ 668


>gi|14591926 Sec23 homolog B [Homo sapiens]
          Length = 767

 Score = 75.1 bits (183), Expect = 3e-13
 Identities = 147/681 (21%), Positives = 255/681 (37%), Gaps = 109/681 (16%)

Query: 394  PQTQALLNKAKLPLGLLLHPFKDLVQLPVVTSSTIVRCR-SCRTYINPFVSFLDQRR--W 450
            P ++    +  +PL  LL P K+   LP V    ++  R +C+  +NP    +D R   W
Sbjct: 25   PSSRLEATRMVVPLACLLTPLKERPDLPPVQYEPVLCSRPTCKAVLNPLCQ-VDYRAKLW 83

Query: 451  KCNLCYRVNDVPEEFLYNPLTRVYGEPHRRPEVQNATIEFMAPSEYMLRPPQPP-VYLFV 509
             CN C++ N  P    Y  ++ V       P  Q +TIE++     + R  Q P ++L+V
Sbjct: 84   ACNFCFQRNQFPP--AYGGISEVNQPAELMP--QFSTIEYV-----IQRGAQSPLIFLYV 134

Query: 510  FDVSHNAVETGYLNSVCQSLLDNLDLLPGNTRTKIGFITFDSTIHFYGLQ-ESLSQPQM- 567
             D     +E   L ++ +SL  +L LLP +    +G ITF   +  + L  E +S+  + 
Sbjct: 135  VD---TCLEEDDLQALKESLQMSLSLLPPD--ALVGLITFGRMVQVHELSCEGISKSYVF 189

Query: 568  -----LIVSDIEDVF------IPMPE--------------NLLVNLNESKELVQDLLKTL 602
                 L    I+D+       +PM +                L  +++    + DLL  L
Sbjct: 190  RGTKDLTAKQIQDMLGLTKPAMPMQQARPAQPQEHPFASSRFLQPVHKIDMNLTDLLGEL 249

Query: 603  ---PQMFTKTLETQSALGPALQAAFKLMS----PTGGRMSVFQTQLPTLGVGALKPREEP 655
               P   T+      + G AL  A  L+      TG R+ +F    PT G G +   E  
Sbjct: 250  QRDPWPVTQGKRPLRSTGVALSIAVGLLEGTFPNTGARIMLFTGGPPTQGPGMVVGDELK 309

Query: 656  NHRSSAKDIH------MTPSTDFYKKLALDCSGQQVAVDLFLLSGQYSDLASLGCISRYS 709
                S  DI       M  +T  Y+ LA   +     +D++  +   + L  + C +  +
Sbjct: 310  IPIRSWHDIEKDNARFMKKATKHYEMLANRTAANGHCIDIYACALDQTGLLEMKCCANLT 369

Query: 710  AGSVYYYPSYHHQHNPVQVQKLQKELQRYLTR------KIGFEAVMRIRCTKGLSIHTFH 763
             G +    S++           ++  QR  T+      ++ F A + ++ ++ L I    
Sbjct: 370  GGYMVMGDSFN-------TSLFKQTFQRIFTKDFNGDFRMAFGATLDVKTSRELKIAGAI 422

Query: 764  G---------------NFFVRSTDLLSLPNVNPDAGYAVQMSV----EESLTDTQLVSFQ 804
            G                  V  T    +  ++P +   +   V       +      + Q
Sbjct: 423  GPCVSLNVKGPCVSENELGVGGTSQWKICGLDPTSTLGIYFEVVNQHNTPIPQGGRGAIQ 482

Query: 805  SALLYTSSKGERRIRVHTLC---LPVVSTLNDVFLGADVQAISGLLANMAVDRSMTASLS 861
                Y  S  +RRIRV T+      V S L  +    D +A + L+A + V R+ +    
Sbjct: 483  FVTHYQHSSTQRRIRVTTIARNWADVQSQLRHIEAAFDQEAAAVLMARLGVFRAESEEGP 542

Query: 862  DARDALVNAVIDSLSAYRSSVLSNQQPGLMVPFSLRLFPLFVLALLKQKSFQTGTNARLD 921
            D    L   +I     +             +  S  L+P F+  L +    Q   N+  D
Sbjct: 543  DVLRWLDRQLIRLCQKF-GQYNKEDPTSFRLSDSFSLYPQFMFHLRRSPFLQVFNNSP-D 600

Query: 922  ERIFAMCQVKNQPLVYLMLTTHPSLYRVDNLSDEGALNISDRTIPQPPILQLSVEKLSRD 981
            E  +       Q L   ++   P LY           + S    P+P +L  S   +  D
Sbjct: 601  ESSYYRHHFARQDLTQSLIMIQPILY-----------SYSFHGPPEPVLLDSS--SILAD 647

Query: 982  GAFLMDAGSVLMLWVGKNCTQ 1002
               LMD    +++++G+   Q
Sbjct: 648  RILLMDTFFQIVIYLGETIAQ 668


>gi|14591928 Sec23 homolog B [Homo sapiens]
          Length = 767

 Score = 75.1 bits (183), Expect = 3e-13
 Identities = 147/681 (21%), Positives = 255/681 (37%), Gaps = 109/681 (16%)

Query: 394  PQTQALLNKAKLPLGLLLHPFKDLVQLPVVTSSTIVRCR-SCRTYINPFVSFLDQRR--W 450
            P ++    +  +PL  LL P K+   LP V    ++  R +C+  +NP    +D R   W
Sbjct: 25   PSSRLEATRMVVPLACLLTPLKERPDLPPVQYEPVLCSRPTCKAVLNPLCQ-VDYRAKLW 83

Query: 451  KCNLCYRVNDVPEEFLYNPLTRVYGEPHRRPEVQNATIEFMAPSEYMLRPPQPP-VYLFV 509
             CN C++ N  P    Y  ++ V       P  Q +TIE++     + R  Q P ++L+V
Sbjct: 84   ACNFCFQRNQFPP--AYGGISEVNQPAELMP--QFSTIEYV-----IQRGAQSPLIFLYV 134

Query: 510  FDVSHNAVETGYLNSVCQSLLDNLDLLPGNTRTKIGFITFDSTIHFYGLQ-ESLSQPQM- 567
             D     +E   L ++ +SL  +L LLP +    +G ITF   +  + L  E +S+  + 
Sbjct: 135  VD---TCLEEDDLQALKESLQMSLSLLPPD--ALVGLITFGRMVQVHELSCEGISKSYVF 189

Query: 568  -----LIVSDIEDVF------IPMPE--------------NLLVNLNESKELVQDLLKTL 602
                 L    I+D+       +PM +                L  +++    + DLL  L
Sbjct: 190  RGTKDLTAKQIQDMLGLTKPAMPMQQARPAQPQEHPFASSRFLQPVHKIDMNLTDLLGEL 249

Query: 603  ---PQMFTKTLETQSALGPALQAAFKLMS----PTGGRMSVFQTQLPTLGVGALKPREEP 655
               P   T+      + G AL  A  L+      TG R+ +F    PT G G +   E  
Sbjct: 250  QRDPWPVTQGKRPLRSTGVALSIAVGLLEGTFPNTGARIMLFTGGPPTQGPGMVVGDELK 309

Query: 656  NHRSSAKDIH------MTPSTDFYKKLALDCSGQQVAVDLFLLSGQYSDLASLGCISRYS 709
                S  DI       M  +T  Y+ LA   +     +D++  +   + L  + C +  +
Sbjct: 310  IPIRSWHDIEKDNARFMKKATKHYEMLANRTAANGHCIDIYACALDQTGLLEMKCCANLT 369

Query: 710  AGSVYYYPSYHHQHNPVQVQKLQKELQRYLTR------KIGFEAVMRIRCTKGLSIHTFH 763
             G +    S++           ++  QR  T+      ++ F A + ++ ++ L I    
Sbjct: 370  GGYMVMGDSFN-------TSLFKQTFQRIFTKDFNGDFRMAFGATLDVKTSRELKIAGAI 422

Query: 764  G---------------NFFVRSTDLLSLPNVNPDAGYAVQMSV----EESLTDTQLVSFQ 804
            G                  V  T    +  ++P +   +   V       +      + Q
Sbjct: 423  GPCVSLNVKGPCVSENELGVGGTSQWKICGLDPTSTLGIYFEVVNQHNTPIPQGGRGAIQ 482

Query: 805  SALLYTSSKGERRIRVHTLC---LPVVSTLNDVFLGADVQAISGLLANMAVDRSMTASLS 861
                Y  S  +RRIRV T+      V S L  +    D +A + L+A + V R+ +    
Sbjct: 483  FVTHYQHSSTQRRIRVTTIARNWADVQSQLRHIEAAFDQEAAAVLMARLGVFRAESEEGP 542

Query: 862  DARDALVNAVIDSLSAYRSSVLSNQQPGLMVPFSLRLFPLFVLALLKQKSFQTGTNARLD 921
            D    L   +I     +             +  S  L+P F+  L +    Q   N+  D
Sbjct: 543  DVLRWLDRQLIRLCQKF-GQYNKEDPTSFRLSDSFSLYPQFMFHLRRSPFLQVFNNSP-D 600

Query: 922  ERIFAMCQVKNQPLVYLMLTTHPSLYRVDNLSDEGALNISDRTIPQPPILQLSVEKLSRD 981
            E  +       Q L   ++   P LY           + S    P+P +L  S   +  D
Sbjct: 601  ESSYYRHHFARQDLTQSLIMIQPILY-----------SYSFHGPPEPVLLDSS--SILAD 647

Query: 982  GAFLMDAGSVLMLWVGKNCTQ 1002
               LMD    +++++G+   Q
Sbjct: 648  RILLMDTFFQIVIYLGETIAQ 668


>gi|38202214 SEC23-related protein A [Homo sapiens]
          Length = 765

 Score = 67.0 bits (162), Expect = 9e-11
 Identities = 143/679 (21%), Positives = 253/679 (37%), Gaps = 107/679 (15%)

Query: 394  PQTQALLNKAKLPLGLLLHPFKDLVQLPVVTSSTIVRCRS-CRTYINPFVSFLDQRR--W 450
            P ++    +  +P+  L  P K+   LP +    ++  R+ CR  +NP    +D R   W
Sbjct: 25   PSSRLEATRMVVPVAALFTPLKERPDLPPIQYEPVLCSRTTCRAVLNPLCQ-VDYRAKLW 83

Query: 451  KCNLCYRVNDVPEEFLYNPLTRVYGEPHRRPEVQNATIEFMAPSEYMLRPPQPP-VYLFV 509
             CN CY+ N  P    Y  ++ +       P  Q ++IE++     +LR PQ P ++L+V
Sbjct: 84   ACNFCYQRNQFPPS--YAGISELNQPAELLP--QFSSIEYV-----VLRGPQMPLIFLYV 134

Query: 510  FDVSHNAVETGYLNSVCQSLLDNLDLLPGNTRTKIGFITFDSTIHFYGLQ-ESLSQ---- 564
             D     +E   L ++ +S+  +L LLP      +G ITF   +  + L  E +S+    
Sbjct: 135  VD---TCMEDEDLQALKESMQMSLSLLP--PTALVGLITFGRMVQVHELGCEGISKSYVF 189

Query: 565  -----------PQMLIVSDI--------EDVFIPMPENLLVNLNESKEL-VQDLLKTL-- 602
                        +ML +S +          V  P P N  +   +  ++ + DLL  L  
Sbjct: 190  RGTKDLSAKQLQEMLGLSKVPLTQATRGPQVQQPPPSNRFLQPVQKIDMNLTDLLGELQR 249

Query: 603  -PQMFTKTLETQSALGPALQAAFKLMS----PTGGRMSVFQTQLPTLGVGALKPREEPNH 657
             P    +      + G AL  A  L+      TG R+ +F     T G G +   E    
Sbjct: 250  DPWPVPQGKRPLRSSGVALSIAVGLLECTFPNTGARIMMFIGGPATQGPGMVVGDELKTP 309

Query: 658  RSSAKDI------HMTPSTDFYKKLALDCSGQQVAVDLFLLSGQYSDLASLGCISRYSAG 711
              S  DI      ++   T  ++ LA   +     +D++  +   + L  + C    + G
Sbjct: 310  IRSWHDIDKDNAKYVKKGTKHFEALANRAATTGHVIDIYACALDQTGLLEMKCCPNLTGG 369

Query: 712  SVYYYPSYHHQHNPVQVQKLQKELQRYLTR------KIGFEAVMRIRCTKGLSIHTFHG- 764
             +    S++           ++  QR  T+      K+GF   + I+ ++ + I    G 
Sbjct: 370  YMVMGDSFN-------TSLFKQTFQRVFTKDMHGQFKMGFGGTLEIKTSREIKISGAIGP 422

Query: 765  --------------NFFVRSTDLLSLPNVNPDAGYAVQMSV----EESLTDTQLVSFQSA 806
                                T    +  ++P    A+   V       +      + Q  
Sbjct: 423  CVSLNSKGPCVSENEIGTGGTCQWKICGLSPTTTLAIYFEVVNQHNAPIPQGGRGAIQFV 482

Query: 807  LLYTSSKGERRIRVHTLC---LPVVSTLNDVFLGADVQAISGLLANMAVDRSMTASLSDA 863
              Y  S G+RRIRV T+        + + ++    D +A + L+A +A+ R+ T    D 
Sbjct: 483  TQYQHSSGQRRIRVTTIARNWADAQTQIQNIAASFDQEAAAILMARLAIYRAETEEGPDV 542

Query: 864  RDALVNAVIDSLSAYRSSVLSNQQPGLMVPFSLRLFPLFVLALLKQKSFQTGTNARLDER 923
               L   +I     +      +         +  L+P F+   L++ SF    N   DE 
Sbjct: 543  LRWLDRQLIRLCQKF-GEYHKDDPSSFRFSETFSLYPQFMFH-LRRSSFLQVFNNSPDES 600

Query: 924  IFAMCQVKNQPLVYLMLTTHPSLYRVDNLSDEGALNISDRTIPQPPILQLSVEKLSRDGA 983
             +       Q L   ++   P LY         A + S    P  P+L L    +  D  
Sbjct: 601  SYYRHHFMRQDLTQSLIMIQPILY---------AYSFSG---PPEPVL-LDSSSILADRI 647

Query: 984  FLMDAGSVLMLWVGKNCTQ 1002
             LMD    ++++ G+   Q
Sbjct: 648  LLMDTFFQILIYHGETIAQ 666


>gi|54860079 nadrin isoform 1 [Homo sapiens]
          Length = 881

 Score = 65.5 bits (158), Expect = 3e-10
 Identities = 76/266 (28%), Positives = 98/266 (36%), Gaps = 30/266 (11%)

Query: 3   QPGIPASGGAPASLQAQNGAALASGSPYTNGPVQNALLSSQESVSQGYNFQLPGSY---- 58
           +P  P S   PA    +N + +ASG    N P Q A  S Q S+ Q +N   P  +    
Sbjct: 578 KPKDPVSAAVPAP--GRNNSQIASGQ---NQP-QAAAGSHQLSMGQPHNAAGPSPHTLRR 631

Query: 59  ----PHPIPAKTLNPVSGQSNYGGSQGSGQ---TLNRPPVASNPVTPSLHSGPAPRMPLP 111
               P P P K  NP  G      S G+ Q   +L+  P   +P  P+ H+G  P  P  
Sbjct: 632 AVKKPAPAPPKPGNPPPGHPGGQSSSGTSQHPPSLSPKPPTRSPSPPTQHTGQPPGQPSA 691

Query: 112 ASQNPATTPMPSSSFLPEANLPPPLNWQYNYPSTASQTNHCPRASSQPTVSGNTSLTTNH 171
            SQ   + P   SS L     P       N+P     T   P   ++P   G  +     
Sbjct: 692 PSQ--LSAPRRYSSSLSPIQAP-------NHPPPQPPTQATPLMHTKPNSQGPPNPMALP 742

Query: 172 QYVSSGYPSLQNSFIKSGPSVPPL--VNP--PLPTTFQPGAPHGPPPAGGPPPVRALTPL 227
                  PS       + PS PPL   NP  P P T   G P    P  G  P     P 
Sbjct: 743 SEHGLEQPSHTPPQTPTPPSTPPLGKQNPSLPAPQTLAGGNPETAQPHAGTLPRPRPVPK 802

Query: 228 TSSYRDVPQPLFNSAVNQEGITSNTN 253
             +   VP P     V+  G +S TN
Sbjct: 803 PRNRPSVPPPPQPPGVHSAGDSSLTN 828


>gi|54860105 nadrin isoform 2 [Homo sapiens]
          Length = 803

 Score = 65.5 bits (158), Expect = 3e-10
 Identities = 76/266 (28%), Positives = 98/266 (36%), Gaps = 30/266 (11%)

Query: 3   QPGIPASGGAPASLQAQNGAALASGSPYTNGPVQNALLSSQESVSQGYNFQLPGSY---- 58
           +P  P S   PA    +N + +ASG    N P Q A  S Q S+ Q +N   P  +    
Sbjct: 500 KPKDPVSAAVPAP--GRNNSQIASGQ---NQP-QAAAGSHQLSMGQPHNAAGPSPHTLRR 553

Query: 59  ----PHPIPAKTLNPVSGQSNYGGSQGSGQ---TLNRPPVASNPVTPSLHSGPAPRMPLP 111
               P P P K  NP  G      S G+ Q   +L+  P   +P  P+ H+G  P  P  
Sbjct: 554 AVKKPAPAPPKPGNPPPGHPGGQSSSGTSQHPPSLSPKPPTRSPSPPTQHTGQPPGQPSA 613

Query: 112 ASQNPATTPMPSSSFLPEANLPPPLNWQYNYPSTASQTNHCPRASSQPTVSGNTSLTTNH 171
            SQ   + P   SS L     P       N+P     T   P   ++P   G  +     
Sbjct: 614 PSQ--LSAPRRYSSSLSPIQAP-------NHPPPQPPTQATPLMHTKPNSQGPPNPMALP 664

Query: 172 QYVSSGYPSLQNSFIKSGPSVPPL--VNP--PLPTTFQPGAPHGPPPAGGPPPVRALTPL 227
                  PS       + PS PPL   NP  P P T   G P    P  G  P     P 
Sbjct: 665 SEHGLEQPSHTPPQTPTPPSTPPLGKQNPSLPAPQTLAGGNPETAQPHAGTLPRPRPVPK 724

Query: 228 TSSYRDVPQPLFNSAVNQEGITSNTN 253
             +   VP P     V+  G +S TN
Sbjct: 725 PRNRPSVPPPPQPPGVHSAGDSSLTN 750


>gi|150417989 cyclin K isoform 1 [Homo sapiens]
          Length = 580

 Score = 62.0 bits (149), Expect = 3e-09
 Identities = 53/163 (32%), Positives = 70/163 (42%), Gaps = 24/163 (14%)

Query: 93  SNPVTPSLHSGPAPRMPLPASQNPATTPMP-SSSFLPEANLPPPLNWQYNYPSTASQTNH 151
           ++P  P  H  P  + PL A+   A  P P  ++ LP+  +PPP      +P+   Q   
Sbjct: 361 THPPLPPAHPPPDRKPPLAAALGEAEPPGPVDATDLPKVQIPPPA-----HPAPVHQPPP 415

Query: 152 CP-RASSQPTVSGNTSLTTNHQYVSS-GYPSLQNSFIKSGPS---VPPLVNPPLPTTFQP 206
            P R    P  S  T ++T   Y+S  GY SLQ+     GPS   +PP   PP      P
Sbjct: 416 LPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPP---AHLP 472

Query: 207 GAPHGPPPAGGPPPV---------RALTPLTSSYRDVPQPLFN 240
             PH  PP   PPPV          A+ P T  Y   P P +N
Sbjct: 473 YHPHVYPPNPPPPPVPPPPASFPPPAIPPPTPGY-PPPPPTYN 514



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 50/172 (29%), Positives = 63/172 (36%), Gaps = 24/172 (13%)

Query: 54  LPGSYPHPIPAKTLNPVSGQSNYGGSQG--SGQTLNRPPVASNPVTPSLHSGPA--PRMP 109
           LP   P P P+  +  +S  S+Y   +G  S Q++ +    S    P  +  PA  P  P
Sbjct: 416 LPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLPYHP 475

Query: 110 --LPASQNPATTPMPSSSFLPEANLPPPLNWQYNYPSTASQTNHCPRASSQPTVSGNTSL 167
              P +  P   P P +SF P A +PPP      YP      N  P     P     T  
Sbjct: 476 HVYPPNPPPPPVPPPPASFPPPA-IPPPTP---GYPPPPPTYN--PNFPPPPPRLPPTHA 529

Query: 168 TTNHQYVSSGYPSLQNSFIKSGPSVPPLVNPPLPTTFQPGAPHGPPPAGGPP 219
              H     G P           S PP   P +P   QP  P   PP G PP
Sbjct: 530 VPPHPPPGLGLPPA---------SYPP---PAVPPGGQPPVPPPIPPPGMPP 569



 Score = 39.3 bits (90), Expect = 0.021
 Identities = 76/348 (21%), Positives = 106/348 (30%), Gaps = 65/348 (18%)

Query: 62  IPAKTLNPVSGQSNYGGSQGSGQTLNRPPVASNPVTPSLHSGPAPRMPLPASQNPATTPM 121
           +P   L  +  Q     SQG  Q  +  P       PSL   P P++P      P+ +  
Sbjct: 242 VPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQ-PPSLQ--PTPQVPQVQQSQPSQSSE 298

Query: 122 PSSSFLPEANLPPPLNWQYNYPSTASQTNHCPRASSQPTVSGNTSLTTNHQYVSSGYPSL 181
           PS     +   P         P   S     PR   +  V          +      P +
Sbjct: 299 PSQPQQKDPQQPAQQQQPAQQPKKPSPQPSSPRQVKRAVVVSPKEENKAAEPPPPKIPKI 358

Query: 182 QNSFIKSGPSVPPLVN-PPLPTTFQPGAPHGP-----------PPAGGPPPVRALTPLTS 229
           + +     P+ PP    PPL        P GP           PP   P PV    PL  
Sbjct: 359 ETTHPPLPPAHPPPDRKPPLAAALGEAEPPGPVDATDLPKVQIPPPAHPAPVHQPPPLP- 417

Query: 230 SYRDVPQPLFNSAVNQEGITSNTNNGSMVVHSSYDEIEGGGLLATPQLTNKNPKMSRSVG 289
            +R  P P             ++    M   SSY   EG   L +         M ++ G
Sbjct: 418 -HRPPPPP------------PSSYMTGMSTTSSYMSGEGYQSLQS---------MMKTEG 455

Query: 290 YSYPSLPPGY--------------QNTTPPGA---------TGVPPSSLNYPSGPQAFTQ 326
            SY +LPP Y               N  PP             +PP +  YP  P  +  
Sbjct: 456 PSYGALPPAYGPPAHLPYHPHVYPPNPPPPPVPPPPASFPPPAIPPPTPGYPPPPPTYNP 515

Query: 327 T-PLGANHLTTSMSGLSLQPEGLRVVNLLQERNMLP---STPLKPPVP 370
             P     L  + +     P GL +         +P     P+ PP+P
Sbjct: 516 NFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPPPIP 563


>gi|163965366 nascent polypeptide-associated complex alpha subunit
            isoform a [Homo sapiens]
          Length = 2078

 Score = 62.0 bits (149), Expect = 3e-09
 Identities = 91/347 (26%), Positives = 125/347 (36%), Gaps = 71/347 (20%)

Query: 4    PGIPASGGAPASLQAQNGAALASGSPYTNGPVQNALLSSQESVSQGYNFQLPGSYPHPIP 63
            P  PA   APA     +    A  +P   G                    +P S P P  
Sbjct: 900  PATPAPKQAPALSMTSSSPKKARATPAPKG--------------------IPAS-PSPKG 938

Query: 64   AKTLNPVSGQSNYGG-SQGSGQTLNRPPVAS------NPVTPSLHSGPAPRMPLPAS-QN 115
            A T    +  S  GG +  S +    PP A+       P TPS    P P    P S + 
Sbjct: 939  APTPPAATPPSPKGGPATPSPKWAPTPPAATPPSPKGGPATPSPKGAPTPPAATPPSPKG 998

Query: 116  PATTPMPSSSFLPEANLPPPLNWQ---YNYPSTASQTNHCPRASSQPTVSGNTSLTTNHQ 172
               TP P  +  P A  PP          +P  AS     P A++ P+  G+ + T    
Sbjct: 999  GPATPSPKGAPTPPAVTPPSPKGSPAATPFPKGAST----PPAATPPSPKGSPAATP--- 1051

Query: 173  YVSSGYPSLQNSFI---KSGPSVPPLVNPPLPTTFQPGAPHG----PPPAGGPPPVRALT 225
             +  G P+   + +   K GP+ P L   P P    P +P G    P P G P P  A T
Sbjct: 1052 -LPKGAPTTPAATLPSPKGGPATPSLKGAPTPPAATPPSPKGGPATPSPKGAPMP-PAAT 1109

Query: 226  PLTSSYRDVPQPLFNSAVNQEGITSNTNNGSMVVHSSYDEIEGGGLLATPQLTNKNPKMS 285
            P        P P       + G+ +  + G+    ++      GGL   P      PK +
Sbjct: 1110 P--------PSP-------KGGLATPPHKGAPTTPAATPPSPKGGLATPP------PKGA 1148

Query: 286  RSVGYSYPSLPPGYQNTTPP-GATGVPPSSLNYPSGPQAFTQTPLGA 331
             +   + P  P G   T PP GA   P ++   P G  A T +P GA
Sbjct: 1149 PTTPAATPPSPKGGLATPPPKGAPTTPAATPPSPKGGLA-TPSPKGA 1194



 Score = 50.1 bits (118), Expect = 1e-05
 Identities = 64/260 (24%), Positives = 80/260 (30%), Gaps = 29/260 (11%)

Query: 89   PPVASNPVTPSLHSGPAPRMPLPASQNPATTPMPSSSFLPEANLPPPLNWQYNYPSTASQ 148
            P    +P  PS    P P    P S    T P   +      NLP P       P+T   
Sbjct: 850  PATTHSPTPPSPKGAPTPSAVTPLSPKGVTLPPKETPTPSVVNLPFPKEG----PAT--- 902

Query: 149  TNHCPRASSQPTVSGNTSLTTNHQYVSSGYPSLQNSFIKSGPSVPPLVNPPLPTTFQPGA 208
                P     P +S  TS +      +     +  S    G   PP   PP P     G 
Sbjct: 903  ----PAPKQAPALS-MTSSSPKKARATPAPKGIPASPSPKGAPTPPAATPPSP----KGG 953

Query: 209  PHGPPPAGGPPPVRALTPLTSSYRDVPQPLFNSAVNQEGITSNTNNGSMVVHSSYDEIEG 268
            P  P P   P P  A  P        P P    A      T  +  G     S       
Sbjct: 954  PATPSPKWAPTPPAATPPSPKGGPATPSP--KGAPTPPAATPPSPKGGPATPSP------ 1005

Query: 269  GGLLATPQLTNKNPKMSRSVGYSYP---SLPPGYQNTTPPGATGVPPSSLNYPSGPQAFT 325
             G    P +T  +PK S      +P   S PP     +P G+    P     P+ P A  
Sbjct: 1006 KGAPTPPAVTPPSPKGS-PAATPFPKGASTPPAATPPSPKGSPAATPLPKGAPTTPAATL 1064

Query: 326  QTPLGANHLTTSMSGLSLQP 345
             +P G    T S+ G    P
Sbjct: 1065 PSPKG-GPATPSLKGAPTPP 1083



 Score = 47.8 bits (112), Expect = 6e-05
 Identities = 77/291 (26%), Positives = 98/291 (33%), Gaps = 53/291 (18%)

Query: 59   PHPIPAKTLNPVSGQSNYGGSQGSGQT-----LNRPPVASNPVTPSLHSGPAPRM----P 109
            P P  A T + V+  S  G +    +T     +N P     P TP+    PA  M    P
Sbjct: 859  PSPKGAPTPSAVTPLSPKGVTLPPKETPTPSVVNLPFPKEGPATPAPKQAPALSMTSSSP 918

Query: 110  LPASQNPA-----TTPMPSSSFLPEANLPPPLNWQYNYPSTAS-QTNHCPRASSQPTVSG 163
              A   PA      +P P  +  P A  PP        P+T S +    P A++ P+  G
Sbjct: 919  KKARATPAPKGIPASPSPKGAPTPPAATPPS---PKGGPATPSPKWAPTPPAATPPSPKG 975

Query: 164  NTSLTTNHQYVSSGYPSLQNSFIKSGPSVPPLVNPPLPTTFQPGAPHGPPPAGGPPPVRA 223
              +  +                   G   PP   PP P     G P  P P G P P  A
Sbjct: 976  GPATPS-----------------PKGAPTPPAATPPSP----KGGPATPSPKGAPTP-PA 1013

Query: 224  LTPLTSSYRDVPQPLFNSAVNQEGITSNTNNGSMVVHSSYDEIEGGGLLATPQLTNKNPK 283
            +TP +        P    A      T  +  GS             G   TP  T  +PK
Sbjct: 1014 VTPPSPKGSPAATPFPKGASTPPAATPPSPKGSPAATPL-----PKGAPTTPAATLPSPK 1068

Query: 284  MSRSVGYSYPSL--PPGYQNTTPPGATGVP--PSSLNYPSGPQAFTQTPLG 330
                 G + PSL   P     TPP   G P  PS    P  P A   +P G
Sbjct: 1069 ----GGPATPSLKGAPTPPAATPPSPKGGPATPSPKGAPMPPAATPPSPKG 1115



 Score = 47.0 bits (110), Expect = 1e-04
 Identities = 72/327 (22%), Positives = 102/327 (31%), Gaps = 23/327 (7%)

Query: 59   PHPIPAKTLNPVSGQSNYGG-SQGSGQTLNRPPVASNP------VTPSLHSGPA-PRMPL 110
            P P  A T    +  S  GG +  S +     P A+ P       TPS    P  P    
Sbjct: 1189 PSPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATP 1248

Query: 111  PASQNPATTPMPSSSFLPEANLPPPLNWQYNYPSTASQTNHCPRASSQPTVSGNTSLTTN 170
            P+ +    TP P  +  P A  PP L      P      N  P   + P+  G  +  T+
Sbjct: 1249 PSPKGGPATPPPKGAPTPPAATPPSLKGGLATPPHKGAPN--PAVVTPPSPKGGPA--TS 1304

Query: 171  HQYVSSGYPSLQNSFIKSGPSVPPLVNPPLPTTFQPGAPHGPPPAGGPPPVRALTPLTSS 230
                +   P+      K  P  PP    P P    P +P G P      P     P T S
Sbjct: 1305 PPKGAPTPPAATPPSPKGSPGTPPPKGAPTPPAVTPPSPKGTPTLPATTPSSKGGPTTPS 1364

Query: 231  YRDVPQPLFNSAVNQEG---ITSNTNNGSMVVHSSYDEIEGGGLLATPQLTNKNPKMSRS 287
             ++ P P   +  ++ G      +   G  +     D      +  +P+     P     
Sbjct: 1365 SKEGPTPPAATPSHKGGPAMTPPSPKRGPAIPSPKGDPTSPAVIPLSPKKAPATPVTREG 1424

Query: 288  VGYSYPSLPPGYQNTTPPGATGVPPSSLNYPSGPQAFTQTP--LGANHLTTSMSGLSLQP 345
                  +  P   + TPP  T V        S P+    TP   G   L         +P
Sbjct: 1425 ------AATPSKGDLTPPAVTPVSLKKAPATSAPKGGPATPSSKGDPTLPAVTPPSPKEP 1478

Query: 346  EGLRVVNLLQERNMLPSTPLKPPVPNL 372
               + V         P+TP     P L
Sbjct: 1479 PAPKQVATSSSPKKAPATPAPMGAPTL 1505



 Score = 44.7 bits (104), Expect = 5e-04
 Identities = 74/320 (23%), Positives = 106/320 (33%), Gaps = 42/320 (13%)

Query: 95   PVTPSLHSGP-APRMPLPASQNPATTPMPSSSFLPEANLPPPLNWQ-YNYPSTASQTNHC 152
            P TPS    P AP   L + + PAT     +   P   +P P        P  A  T   
Sbjct: 1517 PATPSSRRDPIAPTATLLSKKTPATLAPKEALIPPAMTVPSPKKTPAIPTPKEAPATPSS 1576

Query: 153  PRASSQPTVSGNTSLTTNHQYVSSGYPSLQNSFIKSGPSVPPLVNPPLPTTFQPGAPHGP 212
              ASS P V+ +T           G PS +   I    + P     P P    P +P   
Sbjct: 1577 KEASSPPAVTPSTY---------KGAPSPKELLIPPAVTSPSPKEAPTPPAVTPPSPEKG 1627

Query: 213  PPAGGPPPVRALTPLT-SSYRDVPQPLFNSAVNQEGITSNTNNG--SMVVHSSYDEI--- 266
            P    P       P+T SS +D P    +            + G  +    ++  E+   
Sbjct: 1628 PATPAPKGTPTSPPVTPSSLKDSPTSPASVTCKMGATVPQASKGLPAKKGPTALKEVLVA 1687

Query: 267  ---EGGGLLATPQLTNKNPKMSRSVGYSYPSLP-PGYQNTTPPGATGVPPSSL------- 315
               E   ++  P  T K P+  +S   S P  P P  +N +    + V P+ L       
Sbjct: 1688 PAPESTPIITAP--TRKGPQTKKSSATSPPICPDPSAKNGSKGPLSTVAPAPLLPVQKDS 1745

Query: 316  ----------NYPSGPQAFTQTPLGANHLTTSMSGLSLQPEGLRVVNLLQERNMLPSTPL 365
                      + P GP A  ++         +   +  +PE   V         LP  P 
Sbjct: 1746 SKTAKGKDASHSPKGPLAPPESKASTPLTAAAFEKVLPKPESASVSAAPSPPVSLPLAP- 1804

Query: 366  KPPVPNLHEDIQKLNCNPEL 385
              PVP L    Q L  +P L
Sbjct: 1805 -SPVPTLPPKQQFLPSSPGL 1823



 Score = 38.9 bits (89), Expect = 0.027
 Identities = 83/376 (22%), Positives = 139/376 (36%), Gaps = 54/376 (14%)

Query: 19  QNGAALASGSPYTNGPVQNALLSSQESVSQGYNFQLPGS-YPHPIPAKTLNPVSGQSNYG 77
           +N  +  S S     P+      +++S+ +      P S    P+   +   V    +Y 
Sbjct: 568 KNSPSFQSTSSSPEIPLSPEATLAKKSLGEPLPIGKPASSMTSPLGVNSSASVIKTDSYA 627

Query: 78  GSQGSGQTLNR----PPVASNPVTPSLHSGPAPRMPLPASQNPATTPMPSSSFLP-EANL 132
           G   +G  L      P VA+ P+  +  +G AP      ++  +T    +S FL    +L
Sbjct: 628 GPDSAGPLLKSSLITPTVAAFPLESADPAGVAPT----TAKGTSTYTTTASPFLEGTVSL 683

Query: 133 PPPLNWQYNYPSTASQTNHCPRASSQPTVSGNTSLTTNHQYVSSGYPSLQNSFIKSGPSV 192
            P      N+P         P     PT S N  +  + Q   +   +L  +     P +
Sbjct: 684 APK-----NHPVKEGTLTTLPLV---PTASENCPVAPSPQNTCAPLATLVLA-----PEI 730

Query: 193 PPLVNPPLPTTFQPGAPHGPPPAGGPPPVRALTPLTSSYRDVPQPLFNSAVNQEGITSNT 252
           P  V  P P+    G P G     G     AL P+ SS ++ P           G ++  
Sbjct: 731 PKSV--PSPSLPPAGTPPGTKKVDGISHTSALAPVASSPKECP-------TEDSGASATA 781

Query: 253 NNGSMVVHSSYDEIEGGGLLATPQLTNKNPKMSRSVGYSYPSLPPGYQNT--TPPGATGV 310
           ++   + + + D     G+  +PQ T + P    S G   P  P G  ++  +P  A+ +
Sbjct: 782 SSKGTLTYLA-DSPSPLGVSVSPQ-TKRPPTKKGSAG---PDTPIGNLSSPVSPVEASFL 836

Query: 311 PPSSLNY----PSGPQAFTQTPLGANHLTTSMSGLSLQPEGL----------RVVNLLQE 356
           P +SL++     S     + TP       T  +   L P+G+           VVNL   
Sbjct: 837 PENSLSFQGSKDSPATTHSPTPPSPKGAPTPSAVTPLSPKGVTLPPKETPTPSVVNLPFP 896

Query: 357 RNMLPSTPLKPPVPNL 372
           +   P+TP     P L
Sbjct: 897 KEG-PATPAPKQAPAL 911



 Score = 34.3 bits (77), Expect = 0.66
 Identities = 43/182 (23%), Positives = 67/182 (36%), Gaps = 11/182 (6%)

Query: 63   PAKTLNPVSGQSNYGGSQGSGQTLNRPPVASNPVTPSLHSGP----APRMPLPASQNPAT 118
            PA    P+       G Q    +   PP+  +P   +   GP    AP   LP  ++ + 
Sbjct: 1688 PAPESTPIITAPTRKGPQTKKSSATSPPICPDPSAKNGSKGPLSTVAPAPLLPVQKDSSK 1747

Query: 119  TPM-PSSSFLPEANLPPPLNWQYNYPSTASQTNHCPRASSQPTVSGNTSLTTNHQYVSSG 177
            T     +S  P+  L PP + + + P TA+            +VS   S   +     S 
Sbjct: 1748 TAKGKDASHSPKGPLAPPES-KASTPLTAAAFEKVLPKPESASVSAAPSPPVSLPLAPSP 1806

Query: 178  YPSL--QNSFIKSGPSVPPLVNPPLPTTFQPGAPHGPPPAGGPPPVRALTPLTSSYRDVP 235
             P+L  +  F+ S P +  L +P  P    P       P   P P+    P  S   ++P
Sbjct: 1807 VPTLPPKQQFLPSSPGL-VLESPSKP--LAPADEDELLPLIPPEPISGGVPFQSVLVNMP 1863

Query: 236  QP 237
             P
Sbjct: 1864 TP 1865



 Score = 33.5 bits (75), Expect = 1.1
 Identities = 94/447 (21%), Positives = 155/447 (34%), Gaps = 89/447 (19%)

Query: 80  QGSGQTLNRPPVASNPVTPSLHSGPAPRMPLPASQNP---------ATTPMPSSSFLPEA 130
           Q   +T   P  ++  VT +L   P P +P P S  P           +P PS S +  A
Sbjct: 18  QPQAETAVLPMSSALSVTAALGQ-PGPTLPPPCSPAPQQCPLSAANQASPFPSPSTI--A 74

Query: 131 NLPPPLNWQYNYPSTASQTNHCPRASS----------------------QPTVSGNTSLT 168
           + P  + +  +   TA      P A +                       PT+ G  S +
Sbjct: 75  STPLEVPFPQSSSGTALPLGTAPEAPTFLPNLIGPPISPAALALASPMIAPTLKGTPSSS 134

Query: 169 TNHQYVSSGYPSLQNS------FIKSGPSVPPLVNPPLPTTFQPGAPHGPP--------- 213
                V+    S+Q S       + S PSV    +  + T   P AP  P          
Sbjct: 135 APLALVALAPHSVQKSSAFPPNLLTSPPSVAVAESGSVITLSAPIAPSEPKTNLNKVPSE 194

Query: 214 ----PAGGPPP-----------VRALTPLTSSYRDVPQ--PLFNSAVNQEGITSNTNNGS 256
               P G P P           V  +  + S    +PQ  P    A+    +   T +  
Sbjct: 195 VVPNPKGTPSPPCIVSTVPYHCVTPMASIQSGVASLPQTTPTTTLAIASPQVKDTTISSV 254

Query: 257 MVVHSSYDEIEGGGLLATPQL----TNKNPKMSRSVGYSYPSLPPGY-----QNTTPPGA 307
           ++   +   +   G ++ P      T   P ++ S   + P+ PP +      +  P   
Sbjct: 255 LISPQNPGSLSLKGPVSPPAALSLSTQSLPVVTSSQKTAGPNTPPDFPISLGSHLAPLHQ 314

Query: 308 TGVPPSSLNYPSGPQAFTQTPLGANHLTTSMSGLSLQPEGLRVVNLLQERN-MLPST--- 363
           +      L   +GP A +   +    +  S +G S  P    V+  L  RN ++P+T   
Sbjct: 315 SSFGSVQLLGQTGPSALSDPTVKTISVDHSSTGAS-YPSQRSVIPPLPSRNEVVPATVAA 373

Query: 364 --PLKPPVPNLHEDIQKLNCNP--ELFRCTLTSIPQTQALLNKAKLPLGLLLHPFKDLVQ 419
              + P V      I  + C+P   L   T  S+  T +L+ K+  P     +P   + Q
Sbjct: 374 FPVVAPSVDKGPSTISSITCSPSGSLNVATSFSLSPTTSLILKSS-PNATYHYPL--VAQ 430

Query: 420 LPV--VTSSTIVRCRSCRTYINPFVSF 444
           +PV  V ++ +V    C     P  +F
Sbjct: 431 MPVSSVGTTPLVVTNPCTIAAAPTTTF 457



 Score = 33.1 bits (74), Expect = 1.5
 Identities = 85/376 (22%), Positives = 129/376 (34%), Gaps = 64/376 (17%)

Query: 4   PGIPASGGAPASLQAQNGAALASGSPYTNGPVQNALLSSQESVSQGYNF--QLPGSYPHP 61
           P +       +S+      +L   + ++  P  + +L S  + +  Y    Q+P S    
Sbjct: 379 PSVDKGPSTISSITCSPSGSLNVATSFSLSPTTSLILKSSPNATYHYPLVAQMPVSSVGT 438

Query: 62  IPAKTLNPVSGQSNYGGSQGSGQTLNRPPVASNPVTPSLHSGP-----APRMPL-PASQN 115
            P    NP +  +    +     T   PP++S P++    + P     AP  P  P++Q 
Sbjct: 439 TPLVVTNPCTIAAA-PTTTFEVATCVSPPMSSGPISNIEPTSPAALVMAPVAPKEPSTQV 497

Query: 116 PATTPMPSSSFLPE----ANLPPPLNWQYNYPSTASQTNHCPRASSQPTVSGNTSLTTNH 171
             T  +P S  LP+     NLP  +     +P+              P       LTT  
Sbjct: 498 ATTLRIPVSPPLPDPEDLKNLPSSV--LVKFPTQKDLQTVPASLEGAPFSPAQAGLTTKK 555

Query: 172 --------QYVSSGYPSLQNSFIKSGPSVP--PLVNPPLPTTFQPGAPHGPPPAGGPPPV 221
                   Q      PS Q++   S P +P  P       +  +P  P G P +    P+
Sbjct: 556 DPTVLPLVQAAPKNSPSFQST--SSSPEIPLSPEATLAKKSLGEP-LPIGKPASSMTSPL 612

Query: 222 ----RALTPLTSSYR--DVPQPLFNSAV-------------NQEGITSNTNNGSMVVHSS 262
                A    T SY   D   PL  S++             +  G+   T  G+    S+
Sbjct: 613 GVNSSASVIKTDSYAGPDSAGPLLKSSLITPTVAAFPLESADPAGVAPTTAKGT----ST 668

Query: 263 YDEIEGGGLLATPQLTNKNPKMSRSVGYSYPSLP---------PGYQNTTPPGATGV--- 310
           Y       L  T  L  KN  +      + P +P         P  QNT  P AT V   
Sbjct: 669 YTTTASPFLEGTVSLAPKNHPVKEGTLTTLPLVPTASENCPVAPSPQNTCAPLATLVLAP 728

Query: 311 -PPSSLNYPSGPQAFT 325
             P S+  PS P A T
Sbjct: 729 EIPKSVPSPSLPPAGT 744



 Score = 32.7 bits (73), Expect = 1.9
 Identities = 87/347 (25%), Positives = 118/347 (34%), Gaps = 54/347 (15%)

Query: 22  AALASGSPYTNGPVQNALLSSQESVSQGYNFQLPGSYPHPIPAKTLNP----VSGQSNYG 77
           AALA  SP    P      SS   ++      L    PH +   +  P     S  S   
Sbjct: 114 AALALASPMI-APTLKGTPSSSAPLA------LVALAPHSVQKSSAFPPNLLTSPPSVAV 166

Query: 78  GSQGSGQTLNRPPVASNPVTPSLHSGPAPRMPLPASQNPATTPMPSS--SFLPEANLPPP 135
              GS  TL+ P   S P T +L+  P+  +P     NP  TP P    S +P   + P 
Sbjct: 167 AESGSVITLSAPIAPSEPKT-NLNKVPSEVVP-----NPKGTPSPPCIVSTVPYHCVTPM 220

Query: 136 LNWQYNYPSTASQTNHCPRASSQPTVSGNTSLTTNHQYVSSGYPSLQN--SFIKSGPSVP 193
            + Q    S    T     A + P V   T        +SS   S QN  S    GP  P
Sbjct: 221 ASIQSGVASLPQTTPTTTLAIASPQVKDTT--------ISSVLISPQNPGSLSLKGPVSP 272

Query: 194 PLV------NPPLPTTFQPGAPHGPPPAGGPPPVRALTPLTSSYRDVPQPLFNSAVNQEG 247
           P        + P+ T+ Q  A    PP         L PL  S     Q L         
Sbjct: 273 PAALSLSTQSLPVVTSSQKTAGPNTPPDFPISLGSHLAPLHQSSFGSVQLL--GQTGPSA 330

Query: 248 ITSNTNNGSMVVHSSYDEIEGGGLLATPQLTNKNPKMSRSVGYSYPSLPPGYQ------- 300
           ++  T     V HSS            P L ++N  +  +V  ++P + P          
Sbjct: 331 LSDPTVKTISVDHSSTGASYPSQRSVIPPLPSRNEVVPATVA-AFPVVAPSVDKGPSTIS 389

Query: 301 --NTTPPGATGV-------PPSSLNYPSGPQAFTQTPLGANHLTTSM 338
               +P G+  V       P +SL   S P A    PL A    +S+
Sbjct: 390 SITCSPSGSLNVATSFSLSPTTSLILKSSPNATYHYPLVAQMPVSSV 436



 Score = 32.0 bits (71), Expect = 3.3
 Identities = 69/304 (22%), Positives = 98/304 (32%), Gaps = 33/304 (10%)

Query: 89   PPVASNPVTPSLHSGPAPRMPLPASQNPATTPMP-SSSFLPEANLPPPLNWQYNYPSTAS 147
            P     P  P+    PA      AS  PA TP     +  P+  L PP         T+ 
Sbjct: 1556 PSPKKTPAIPTPKEAPATPSSKEASSPPAVTPSTYKGAPSPKELLIPP-------AVTSP 1608

Query: 148  QTNHCPRASSQPTVSGNTSLTTNHQYVSSGYPSLQNSFIKSGPSVPPLVNPPLPTTFQPG 207
                 P   +    S      T     +   P +  S +K  P+ P  V   +  T  P 
Sbjct: 1609 SPKEAPTPPAVTPPSPEKGPATPAPKGTPTSPPVTPSSLKDSPTSPASVTCKMGATV-PQ 1667

Query: 208  APHGPPPAGGP--------PPVRALTP-LTSSYRDVPQPLFNSAVNQEGITS-NTNNGSM 257
            A  G P   GP         P    TP +T+  R  PQ   +SA +       +  NGS 
Sbjct: 1668 ASKGLPAKKGPTALKEVLVAPAPESTPIITAPTRKGPQTKKSSATSPPICPDPSAKNGS- 1726

Query: 258  VVHSSYDEIEGGGLLATPQLTNKNPK-MSRSVGYSYPSLPPGYQNTTPPGATGV-----P 311
                    +    LL   + ++K  K    S     P  PP  + +TP  A         
Sbjct: 1727 --KGPLSTVAPAPLLPVQKDSSKTAKGKDASHSPKGPLAPPESKASTPLTAAAFEKVLPK 1784

Query: 312  PSSLNYPSGPQAFTQTPLGANHLTTSMSGLSLQPEGLRVVNLLQERNMLPS-----TPLK 366
            P S +  + P      PL  + + T        P    +V     + + P+      PL 
Sbjct: 1785 PESASVSAAPSPPVSLPLAPSPVPTLPPKQQFLPSSPGLVLESPSKPLAPADEDELLPLI 1844

Query: 367  PPVP 370
            PP P
Sbjct: 1845 PPEP 1848


>gi|151301154 mucin 6, gastric [Homo sapiens]
          Length = 2439

 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 74/332 (22%), Positives = 117/332 (35%), Gaps = 48/332 (14%)

Query: 13   PASLQAQNGAALASGSPYTNGPVQN-----------ALLSSQESVSQGYNFQLPGSY--- 58
            P   QA   A  ++ SP T    Q+           A   +  ++ +  N +LPG+    
Sbjct: 1299 PTVTQATTRATASTASPATTSTAQSTTRTTMTLPTPATSGTSPTLPKSTNQELPGTTATQ 1358

Query: 59   ---PHPIPAKTLNPVSGQSNYGGSQGSGQTLNRPPVASNPVTPSLHSGPAPRMPLPASQN 115
               P P PA T  P + Q        + +T             + H+  +P  P   S  
Sbjct: 1359 TTGPRPTPASTTGPTTPQPGQPTRPTATETTQTRTTTEYTTPQTPHTTHSP--PTAGSPV 1416

Query: 116  PATTPMPSSSFLPEANLPPPLNWQYNYPSTASQTNHCPRASSQPTVSGNTSLTTNHQYVS 175
            P+T P+ ++SF      P P     ++P T   T+  P ++S  T S +T +T  H  ++
Sbjct: 1417 PSTGPVTATSFHATTTYPTP-----SHPETTLPTHVPPFSTSLVTPSTHTVITPTHAQMA 1471

Query: 176  SGYPSLQNSFIKSGPSVPPLVNPPLPTTFQPGAPHGPPPAGGPPPVRALTPLTSSYRDVP 235
            +           S  S P    PP  T    G+ H  PP         +TP TS      
Sbjct: 1472 TS---------ASNHSAPTGTIPPPTTLKATGSTHTAPP---------ITPTTSG----T 1509

Query: 236  QPLFNSAVNQEGITSNTNNGSMVVHSSYDEIEGGGLLATPQLTNKNPKMSRSVGYSYPSL 295
                +S    +  TS  ++ S   H          +   P  T     ++ +   +    
Sbjct: 1510 SQAHSSFSTNKTPTSLHSHTSSTHHPEVTPTSTTTITPNPTSTRTRTPVAHTNSATSSRP 1569

Query: 296  PPGYQNTTPPGATGVPPSSLNYPSGPQAFTQT 327
            PP +   +PP  TG  P S   P    +F  T
Sbjct: 1570 PPPFTTHSPP--TGSSPFSSTGPMTATSFKTT 1599



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 77/327 (23%), Positives = 124/327 (37%), Gaps = 40/327 (12%)

Query: 25   ASGSPYTNGPVQNALLSSQESVSQGYNFQLPGSYPHPIPAKTLNP-VSGQSNYGGSQGSG 83
            A+GS +T  P+      + ++ S     + P S  H   + T +P V+  S    +    
Sbjct: 1492 ATGSTHTAPPITPTTSGTSQAHSSFSTNKTPTSL-HSHTSSTHHPEVTPTSTTTITPNPT 1550

Query: 84   QTLNRPPVA-SNPVTPSLHSGPAPRMPLPASQNP--ATTPMPSSSFLPEANLPPPLNWQY 140
             T  R PVA +N  T S    P      P   +P  +T PM ++SF      P P     
Sbjct: 1551 STRTRTPVAHTNSATSSRPPPPFTTHSPPTGSSPFSSTGPMTATSFKTTTTYPTP----- 1605

Query: 141  NYPSTASQTNHCPRASSQPTVSGNTSLTTNHQYVSSGYPSLQNSFIKSGPSVPPLVNPPL 200
            ++P T   T+  P ++S  T S +T +T  H  +++           S  S+P    PP 
Sbjct: 1606 SHPQTTLPTHVPPFSTSLVTPSTHTVITPTHAQMATS---------ASIHSMPTGTIPPP 1656

Query: 201  PTTFQPGAPHGPPPAGGPPPVRALTPLTSSYRDVPQPLFNSAVNQEGI---TSNTNNGSM 257
             T    G+ H  P             LT+S         N+A     +   TS+T++   
Sbjct: 1657 TTLKATGSTHTAP----------TMTLTTSGTSQALSSLNTAKTSTSLHSHTSSTHHAEA 1706

Query: 258  VVHSSYDEIEGGGLLATPQLT-----NKNPKMSRSVGYSYPSLPPGYQNTTPPGATGVPP 312
               S+ +         TP +T         + S S   +  SL     +T  P  T    
Sbjct: 1707 TSTSTTNITPNPTSTGTPPMTVTTSGTSQSRSSFSTAKTSTSLHSHTSSTHHPEVTSTST 1766

Query: 313  SSLNYPSGPQAFTQTPLGANHLTTSMS 339
            +S+  P+     T+TP+   H T++ S
Sbjct: 1767 TSIT-PNHTSTGTRTPVA--HTTSATS 1790



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 60/221 (27%), Positives = 92/221 (41%), Gaps = 30/221 (13%)

Query: 69   PVSGQSNYGGSQGSGQTLNRPPVASNPVTPSLHSGPAPRMPLPAS-QNPATTPMPSSSFL 127
            PV   +   GS  S  T   P  AS   +P   S PA    + A+  +  ++P   S+ L
Sbjct: 2169 PVHSTTLSSGSHSSLST--HPTTASVSASPLFPSSPAASTTIRATLPHTISSPFTLSALL 2226

Query: 128  PEANL---PPPLNWQYNY-------PSTASQTNHCPRASSQPTVSGNTSLTTNHQYVSSG 177
            P + +   P P +   +        P T + T+  P  SSQ T S +TSLTT  +  +SG
Sbjct: 2227 PISTVTVSPTPSSHLASSTIAFPSTPRTTASTHTAPAFSSQSTTSRSTSLTT--RVPTSG 2284

Query: 178  YPSLQNSFIKSGPSVPPLVNPPLPTTFQPGAPHGPPPAGGPPPVRALTPLTSSYRDVPQP 237
            + SL +    +G    P+ N    TT  PG           P  R LT   +++   P  
Sbjct: 2285 FVSLTSGV--TGIPTSPVTN---LTTRHPGPTLS-------PTTRFLTSSLTAHGSTPA- 2331

Query: 238  LFNSAVNQEGITSNTNNGSMVVHSSYDEIEGGGLLATPQLT 278
              ++ V+  G  + T+ G   V    +EI   G +A   +T
Sbjct: 2332 --SAPVSSLGTPTPTSPGVCSVREQQEEITFKGCMANVTVT 2370



 Score = 43.5 bits (101), Expect = 0.001
 Identities = 81/354 (22%), Positives = 123/354 (34%), Gaps = 50/354 (14%)

Query: 25   ASGSPYTNGPVQNALLSSQESVSQGYNFQLPGSYPHPIPAKTLNPVSGQSNYGGSQGSGQ 84
            A+GS +T  P+      + +S S     +   S P+   +     V+  S    +     
Sbjct: 1885 ATGSTHTAPPMTPTTSGTSQSPSSFSTAKTSTSLPYHTSSTHHPEVTPTSTTNITPKHTS 1944

Query: 85   TLNRPPVASN--------PVTPSLHSGPAPRMPLPASQNPATTPMPSSSFLPEANLPPPL 136
            T  R PVA          P   + HS P    P  +     T PM ++SF      P P 
Sbjct: 1945 TGTRTPVAHTTSASSSRLPTPFTTHSPPTGSSPFSS-----TGPMTATSFQTTTTYPTP- 1998

Query: 137  NWQYNYPSTASQTNHCPRASSQPTVSGNTSLTTNHQYVSSGYPSLQNSFIKSGPSVPPLV 196
                ++P T   T+  P ++S  T S +T + T H  +++           S  S P   
Sbjct: 1999 ----SHPQTTLPTHVPPFSTSLVTPSTHTVIITTHTQMATS---------ASIHSTPTGT 2045

Query: 197  NPPLPTTFQPGAPHGPPPAGGPPPVRALTPLTSSYRDVPQPLFNSAVNQEGITSNT---N 253
             PP  T    G+ H  PP         +T  TS           +  +   I+S++    
Sbjct: 2046 VPPPTTLKATGSTHTAPP---------MTVTTSGTSQTHSSFSTATASSSFISSSSWLPQ 2096

Query: 254  NGSMVVHSS--YDEIEGGGLLATPQLTNKNPKMSRSVGYSYPSLPPGYQNTTPPGATGVP 311
            N S    SS    ++       TP  T      S S   S PS    Y     P +   P
Sbjct: 2097 NSSSRPPSSPITTQLPHLSSATTPVSTTNQLSSSFSPSPSAPSTVSSY----VPSSHSSP 2152

Query: 312  PSSLNYPSGPQAFTQTPLGANHLTT-SMSGLSLQPEGLRVVNLLQERNMLPSTP 364
             +S        +F   P+ +  L++ S S LS  P    V        + PS+P
Sbjct: 2153 QTSSPSVGTSSSFVSAPVHSTTLSSGSHSSLSTHPTTASV----SASPLFPSSP 2202



 Score = 37.7 bits (86), Expect = 0.060
 Identities = 56/229 (24%), Positives = 73/229 (31%), Gaps = 47/229 (20%)

Query: 53   QLPGSYPHPIPAKTLNPVSGQSNYGGSQGSGQTLNRPPVASNPVTPSLHSGPAPRMPLPA 112
            QLP +   P     +   S       S G   + N  P AS   TP L +      P  +
Sbjct: 1209 QLPTTGSRPTQVWPMTGTSTTIGLLSSTGPSPSSNHTP-ASPTQTPLLPATLTSSKPTAS 1267

Query: 113  SQNP-----ATTPMPSSSFLPEANL----PPPLNWQYNYPSTASQTNHCPRASSQPTVSG 163
            S  P     A TP  +S   P A L      P   Q    +TAS  +    +++Q T   
Sbjct: 1268 SGEPPRPTTAVTPQATSGLPPTATLRSTATKPTVTQATTRATASTASPATTSTAQSTT-- 1325

Query: 164  NTSLTTNHQYVSSGYPSLQNSFIKSGPSV---------PPLVNPPLPTTFQPGAP----- 209
             T++T      S   P+L  S  +  P           P   +   PTT QPG P     
Sbjct: 1326 RTTMTLPTPATSGTSPTLPKSTNQELPGTTATQTTGPRPTPASTTGPTTPQPGQPTRPTA 1385

Query: 210  ---------------------HGPPPAGGPPPVRALTPLTSSYRDVPQP 237
                                 H PP AG P P       TS +     P
Sbjct: 1386 TETTQTRTTTEYTTPQTPHTTHSPPTAGSPVPSTGPVTATSFHATTTYP 1434



 Score = 30.8 bits (68), Expect = 7.3
 Identities = 60/337 (17%), Positives = 112/337 (33%), Gaps = 38/337 (11%)

Query: 60   HPIPAKTLNPVSGQSNYGGSQ----------GSGQTLNRPPVASNPVTPSLHSGPAPRMP 109
            H +P  T+ P +     G +           G+ Q L+    A    +   H+       
Sbjct: 1646 HSMPTGTIPPPTTLKATGSTHTAPTMTLTTSGTSQALSSLNTAKTSTSLHSHTSSTHHAE 1705

Query: 110  LPASQNPATTPMPSSSFLPEANLPPPLNWQYNYPSTASQTN---HCPRASS---QPTVSG 163
              ++     TP P+S+  P   +      Q     + ++T+   H   +S+   + T + 
Sbjct: 1706 ATSTSTTNITPNPTSTGTPPMTVTTSGTSQSRSSFSTAKTSTSLHSHTSSTHHPEVTSTS 1765

Query: 164  NTSLTTNHQYVSSGYPSLQNSFIKSGPSVPPLVNPPLPTTFQPGAPHGPPPAGGPPPVRA 223
             TS+T NH    +  P    +   S     P       TT  P  P G  P     PV A
Sbjct: 1766 TTSITPNHTSTGTRTPVAHTTSATSSRLPTPF------TTHSP--PTGTTPISSTGPVTA 1817

Query: 224  LTPLTSSYRDVPQ------PLFNSAVNQEGITSNTNNGSMVVHSSYDEIEGGGLLATPQL 277
             +  T++    P       P    + +   +T +T+  ++++ +         + + P  
Sbjct: 1818 TSFQTTTTYPTPSHPHTTLPTHVPSFSTSLVTPSTH--TVIIPTHTQMATSASIHSMPTG 1875

Query: 278  TNKNPKMSRSVGYSY---PSLPPGYQNTTPPGATGVPPSSLNYP---SGPQAFTQTPLGA 331
            T   P   ++ G ++   P  P     +  P +     +S + P   S       TP   
Sbjct: 1876 TIPPPTTIKATGSTHTAPPMTPTTSGTSQSPSSFSTAKTSTSLPYHTSSTHHPEVTPTST 1935

Query: 332  NHLTTSMSGLSLQPEGLRVVNLLQERNMLPSTPLKPP 368
             ++T   +    +       +    R   P T   PP
Sbjct: 1936 TNITPKHTSTGTRTPVAHTTSASSSRLPTPFTTHSPP 1972


>gi|42544125 splicing factor 1 isoform 2 [Homo sapiens]
          Length = 638

 Score = 59.3 bits (142), Expect = 2e-08
 Identities = 74/289 (25%), Positives = 100/289 (34%), Gaps = 70/289 (24%)

Query: 3   QPGIPASGGAPASLQAQNGAALASGSPYTN-GPVQNALLSSQESVSQGYNFQLPGSYPHP 61
           +P  PA+   P SL +       S  P+ N GP ++           G     P S+PHP
Sbjct: 345 RPAAPANNPPPPSLMSTT----QSRPPWMNSGPSESRPYHGMHGGGPGGPGGGPHSFPHP 400

Query: 62  IPAKTLNPVSGQSNYGGSQGSGQTLNRPPVASNPVTPSLHSGPAP---RMPLPASQNPAT 118
           +P+ T         +GG          PP    P  P ++ GP P     P P  Q   +
Sbjct: 401 LPSLT-------GGHGGHPMQHNPNGPPPPWMQPPPPPMNQGPHPPGHHGPPPMDQYLGS 453

Query: 119 TPMPSSSFL----------------------PEANLPPPLN-----WQYNY-------PS 144
           TP+ S  +                       P    PPP +     WQ          P 
Sbjct: 454 TPVGSGVYRLHQGKGMMPPPPMGMMPPPPPPPSGQPPPPPSGPLPPWQQQQQQPPPPPPP 513

Query: 145 TASQTNHCPRASSQPTVSGNTSLTTNH----------QYVSSGYPSLQNSFIKSGPSVPP 194
           ++S  +  P    Q T +  TS  T               S G P +Q +   +   +PP
Sbjct: 514 SSSMASSTPLPWQQNTTTTTTSAGTGSIPPWQQQQAAAAASPGAPQMQGN--PTMVPLPP 571

Query: 195 LVNPPLPTTFQPGAPHGPPP-----AGGPPPVRALTPLTSSYRDVPQPL 238
            V PPLP    PGAP  PPP     AG   P R     +    D P+PL
Sbjct: 572 GVQPPLP----PGAPPPPPPPPPGSAGMMIPPRGGDGPSHESEDFPRPL 616



 Score = 33.9 bits (76), Expect = 0.86
 Identities = 47/186 (25%), Positives = 60/186 (32%), Gaps = 39/186 (20%)

Query: 188 SGPSVPPLVNPPLPTTFQPGAPHGPPPAGGPPPVRALTPLTSSYRDVPQPLFNSAVNQEG 247
           SGP+  PL + P P            PA  PPP     P   S      P  NS  ++  
Sbjct: 333 SGPATTPLASAPRPAA----------PANNPPP-----PSLMSTTQSRPPWMNSGPSES- 376

Query: 248 ITSNTNNGSMVVHSSYDEIEGGGLLATPQLTNKNPKMSRSVGYSYPSLPPGYQ-NTTPPG 306
                          Y  + GGG    P      P    S  +  PSL  G+  +     
Sbjct: 377 -------------RPYHGMHGGG----PGGPGGGP---HSFPHPLPSLTGGHGGHPMQHN 416

Query: 307 ATGVPPSSLNYPSGPQAFTQTPLGANHLTTSMSGLSLQPEGLRVVNLLQERNMLPSTP-- 364
             G PP  +  P  P      P G +        L   P G  V  L Q + M+P  P  
Sbjct: 417 PNGPPPPWMQPPPPPMNQGPHPPGHHGPPPMDQYLGSTPVGSGVYRLHQGKGMMPPPPMG 476

Query: 365 LKPPVP 370
           + PP P
Sbjct: 477 MMPPPP 482


>gi|42544130 splicing factor 1 isoform 1 [Homo sapiens]
          Length = 639

 Score = 58.9 bits (141), Expect = 3e-08
 Identities = 69/266 (25%), Positives = 93/266 (34%), Gaps = 68/266 (25%)

Query: 3   QPGIPASGGAPASLQAQNGAALASGSPYTN-GPVQNALLSSQESVSQGYNFQLPGSYPHP 61
           +P  PA+   P SL +       S  P+ N GP ++           G     P S+PHP
Sbjct: 345 RPAAPANNPPPPSLMSTT----QSRPPWMNSGPSESRPYHGMHGGGPGGPGGGPHSFPHP 400

Query: 62  IPAKTLNPVSGQSNYGGSQGSGQTLNRPPVASNPVTPSLHSGPAP---RMPLPASQNPAT 118
           +P+ T         +GG          PP    P  P ++ GP P     P P  Q   +
Sbjct: 401 LPSLT-------GGHGGHPMQHNPNGPPPPWMQPPPPPMNQGPHPPGHHGPPPMDQYLGS 453

Query: 119 TPMPSSSFL----------------------PEANLPPPLN-----WQYNY-------PS 144
           TP+ S  +                       P    PPP +     WQ          P 
Sbjct: 454 TPVGSGVYRLHQGKGMMPPPPMGMMPPPPPPPSGQPPPPPSGPLPPWQQQQQQPPPPPPP 513

Query: 145 TASQTNHCPRASSQPTVSGNTSLTTNH----------QYVSSGYPSLQNSFIKSGPSVPP 194
           ++S  +  P    Q T +  TS  T               S G P +Q +   +   +PP
Sbjct: 514 SSSMASSTPLPWQQNTTTTTTSAGTGSIPPWQQQQAAAAASPGAPQMQGN--PTMVPLPP 571

Query: 195 LVNPPLPTTFQPGAPHGPPPAGGPPP 220
            V PPLP    PGAP  PPP   PPP
Sbjct: 572 GVQPPLP----PGAPPPPPP---PPP 590


>gi|188497758 ubiquitin associated protein 2-like isoform a [Homo
           sapiens]
          Length = 1087

 Score = 58.9 bits (141), Expect = 3e-08
 Identities = 85/345 (24%), Positives = 133/345 (38%), Gaps = 52/345 (15%)

Query: 15  SLQAQNGAALASGSPYTNG-PVQNALLSSQE--SVSQGYNFQLPG-SYPHPIPAKTLNPV 70
           S++   G+A+ S SP T+  P  N  +S+    + +  ++  L G S+   IP  T    
Sbjct: 634 SVEGATGSAVKSDSPSTSSIPPLNETVSAASLLTTTNQHSSSLGGLSHSEEIPNTTTTQH 693

Query: 71  SG-----QSNYGGSQGSGQTLNRPPVASNPVTPSLHSGPAPRMPLPASQNPATTPMPSSS 125
           S      Q+    S  SG+T           +  LH+       L +S +  +T   + S
Sbjct: 694 SSTLSTQQNTLSSSTSSGRT---------STSTLLHTSVESEANLHSSSSTFSTTSSTVS 744

Query: 126 FLPEANLPPPLNWQYNYPSTASQTNHCPRASSQPTVSGNT---SLTTNHQYVSSGYPSLQ 182
                  PPP+       S +S  N           SG++   SL +N    +S   S+ 
Sbjct: 745 ------APPPV------VSVSSSLN-----------SGSSLGLSLGSNSTVTASTRSSVA 781

Query: 183 NSFIKSGPSVPPLVNPPLPTTF--QPGAPHG-PPPAGGPPPVRAL-TPLTSSYRDVPQPL 238
            +  K+ P++PP V P LP  +   PG  H  PP   G   ++ L T     Y  +P P 
Sbjct: 782 TTSGKAPPNLPPGVPPLLPNPYIMAPGLLHAYPPQVYGYDDLQMLQTRFPLDYYSIPFPT 841

Query: 239 FNSAVNQE--GITSNTNNGSMVVHSSYDEIEGGGL--LATPQLTNKNPKMSRSVGYSYPS 294
             + +      + SN  +G +      D         LA PQ        +    +  P+
Sbjct: 842 PTTPLTGRDGSLASNPYSGDLTKFGRGDASSPAPATTLAQPQQNQTQTHHTTQQTFLNPA 901

Query: 295 LPPGYQNTTPPGATGVPPSSLNYPSGPQAFTQTPLGANHLTTSMS 339
           LPPGY  T+ P  TGVP     +  GP  F   P  +     ++S
Sbjct: 902 LPPGYSYTSLPYYTGVPGLPSTFQYGPAVFPVAPTSSKQHGVNVS 946



 Score = 33.1 bits (74), Expect = 1.5
 Identities = 55/230 (23%), Positives = 75/230 (32%), Gaps = 41/230 (17%)

Query: 57   SYPHPIPAKTL---------NPVSGQ-SNYGGSQGSGQTLNRPPVASNPVTPSLHSGPAP 106
            S P P P   L         NP SG  + +G    S      P  A+    P  +     
Sbjct: 836  SIPFPTPTTPLTGRDGSLASNPYSGDLTKFGRGDASS-----PAPATTLAQPQQNQTQTH 890

Query: 107  RMPLPASQNPATTPMPSSSFLPEANLPPPLNWQYNY--------PSTASQ------TNHC 152
                    NPA  P  S + LP     P L   + Y        P+++ Q       N  
Sbjct: 891  HTTQQTFLNPALPPGYSYTSLPYYTGVPGLPSTFQYGPAVFPVAPTSSKQHGVNVSVNAS 950

Query: 153  PRASSQPTVSGNTSLTTNHQYVSSG----------YPSLQNSFIKSG-PSVPPLVNPPLP 201
                 QP+  G+    T     SS           Y   Q SF K G  S  P  +  LP
Sbjct: 951  ATPFQQPSGYGSHGYNTGVSVTSSNTGVPDISGSVYSKTQQSFEKQGFHSGTPAASFNLP 1010

Query: 202  TTFQPGAPHGPPPAGGPPPVRALTPLTSSYRDVPQPLFNSAVNQEGITSN 251
            +    G P  P  A   PP   +  LT   +   Q + +  + Q+G T +
Sbjct: 1011 SALGSGGPINPATAAAYPPAPFMHILTPHQQPHSQ-ILHHHLQQDGQTGS 1059


>gi|188497756 ubiquitin associated protein 2-like isoform b [Homo
           sapiens]
          Length = 983

 Score = 58.9 bits (141), Expect = 3e-08
 Identities = 85/345 (24%), Positives = 133/345 (38%), Gaps = 52/345 (15%)

Query: 15  SLQAQNGAALASGSPYTNG-PVQNALLSSQE--SVSQGYNFQLPG-SYPHPIPAKTLNPV 70
           S++   G+A+ S SP T+  P  N  +S+    + +  ++  L G S+   IP  T    
Sbjct: 634 SVEGATGSAVKSDSPSTSSIPPLNETVSAASLLTTTNQHSSSLGGLSHSEEIPNTTTTQH 693

Query: 71  SG-----QSNYGGSQGSGQTLNRPPVASNPVTPSLHSGPAPRMPLPASQNPATTPMPSSS 125
           S      Q+    S  SG+T           +  LH+       L +S +  +T   + S
Sbjct: 694 SSTLSTQQNTLSSSTSSGRT---------STSTLLHTSVESEANLHSSSSTFSTTSSTVS 744

Query: 126 FLPEANLPPPLNWQYNYPSTASQTNHCPRASSQPTVSGNT---SLTTNHQYVSSGYPSLQ 182
                  PPP+       S +S  N           SG++   SL +N    +S   S+ 
Sbjct: 745 ------APPPV------VSVSSSLN-----------SGSSLGLSLGSNSTVTASTRSSVA 781

Query: 183 NSFIKSGPSVPPLVNPPLPTTF--QPGAPHG-PPPAGGPPPVRAL-TPLTSSYRDVPQPL 238
            +  K+ P++PP V P LP  +   PG  H  PP   G   ++ L T     Y  +P P 
Sbjct: 782 TTSGKAPPNLPPGVPPLLPNPYIMAPGLLHAYPPQVYGYDDLQMLQTRFPLDYYSIPFPT 841

Query: 239 FNSAVNQE--GITSNTNNGSMVVHSSYDEIEGGGL--LATPQLTNKNPKMSRSVGYSYPS 294
             + +      + SN  +G +      D         LA PQ        +    +  P+
Sbjct: 842 PTTPLTGRDGSLASNPYSGDLTKFGRGDASSPAPATTLAQPQQNQTQTHHTTQQTFLNPA 901

Query: 295 LPPGYQNTTPPGATGVPPSSLNYPSGPQAFTQTPLGANHLTTSMS 339
           LPPGY  T+ P  TGVP     +  GP  F   P  +     ++S
Sbjct: 902 LPPGYSYTSLPYYTGVPGLPSTFQYGPAVFPVAPTSSKQHGVNVS 946


>gi|163914392 glioma tumor suppressor candidate region gene 1 [Homo
            sapiens]
          Length = 1560

 Score = 58.2 bits (139), Expect = 4e-08
 Identities = 97/366 (26%), Positives = 134/366 (36%), Gaps = 58/366 (15%)

Query: 4    PGIPASGGAPASLQAQNGAALASGSPYTNGPVQNALLSSQESVSQGYNFQLP-GSYPH-P 61
            P  P + GA    QA +  A  S +P    P    L     S S     Q P G  PH P
Sbjct: 735  PATPVAKGAGLGPQAPDSQA--SPAPAPQIPAAAPLKGPGPSSSPSLPHQAPLGDSPHLP 792

Query: 62   IPAKTLNPVSGQSNYGGSQGSGQTLNRPPVASNPVTPSLHSGPAPRMP--LPAS---QNP 116
             P  T  P    S         Q+++RPP       P LH  P P+ P  LP     QN 
Sbjct: 793  SPHPTRPPSRPPSR-------PQSVSRPPSE-----PPLHPCPPPQAPPTLPGIFVIQNQ 840

Query: 117  ATTPMPSSSFLPEANLPP--PLNWQYNYPS-TASQTNHCPRASSQPTVSGNTSLTTNHQY 173
               P P+S+  P A  PP  PL  Q   P        H P +S+   V+ ++  ++    
Sbjct: 841  LGVPPPASNPAPTAPGPPQPPLRPQSQPPEGPLPPAPHLPPSSTSSAVASSSETSSRLPA 900

Query: 174  VSSGYPSLQNSFIKSGPSVPPLVNP-PLPTTFQPGAPHGPPPAGGPPPVRALTPLTSSYR 232
                 P+  +  ++  PS  P  +P P PT      P  PPP    PP R    +T+ + 
Sbjct: 901  -----PTPSDFQLQFPPSQGPHKSPTPPPTLHLVPEPAAPPP----PPPRTFQMVTTPFP 951

Query: 233  DVPQPLFNSAVNQEGITSNTNNGSMVVHSSYDEIEGGGLLATPQL-TNKNPKMSRSVGY- 290
             +PQP            +       V      + + GG  A PQ  T+  P  S +    
Sbjct: 952  ALPQP-----------KALLERFHQVPSGIILQNKAGGAPAAPQTSTSLGPLTSPAASVL 1000

Query: 291  -------SYPSLPPGYQNTTPPGATGVPPSSLNYPSGPQAFTQTPLGANHLTTSMSGLSL 343
                     P+ P       P  ATG+PP     P+  +AF       N    + SG   
Sbjct: 1001 VSGQAPSGTPTAPSHAPAPAPMAATGLPPL---LPAENKAFASNLPTLNVAKAASSGPG- 1056

Query: 344  QPEGLR 349
            +P GL+
Sbjct: 1057 KPSGLQ 1062



 Score = 49.7 bits (117), Expect = 2e-05
 Identities = 103/415 (24%), Positives = 143/415 (34%), Gaps = 81/415 (19%)

Query: 4   PGIPASGGAPASLQAQ----NGAALASGSPYTNGP-VQNALLSSQESVSQGYNFQLPGSY 58
           PG PA    P  L A      G  LA+ +P+T G  + N +L++Q       N   P S 
Sbjct: 475 PGAPAVQ-LPQQLSALPANVGGQILAAAAPHTGGQLIANPILTNQ-------NLAGPLSL 526

Query: 59  PHPIPAKTLNPVSGQSNYGGSQGSGQTLNRPPVASNPVTPSLHSGPAPRMPLPASQNPAT 118
                   L P SG  +      +   + +P +   PV  SL +G  P    PA   PA 
Sbjct: 527 -----GPVLAPHSGAHSAHILSAAPIQVGQPALFQMPV--SLAAGSLPTQSQPAPAGPAA 579

Query: 119 TPMPSSSFLPEANLPPPLNWQYNYPSTASQTNHCPRASSQPTVSGNTSLTTNHQYVSSGY 178
           T +     L    LPP      N P    Q    P   +  T      LT          
Sbjct: 580 TTV-----LQGVTLPPSAVAMLNTPDGLVQ----PATPAAATGEAAPVLT---------- 620

Query: 179 PSLQNSFIKSGPSVPPLVNPPLPTTFQPGAPHGPPPAGGPPPVRALTPLTSSYRDVPQPL 238
                  ++  P  PP V+ PLP   Q      PP A  P P  A  P  ++    PQP 
Sbjct: 621 -------VQPAPQAPPAVSTPLPLGLQQPQAQQPPQA--PTPQAAAPPQATT----PQPS 667

Query: 239 FNSAVNQEGIT-SNTNNGSMVVHSSYDEIEGGGLLATPQLTNKNPKMSRSVGYSYP---- 293
              A + E I      + +     + D ++    +  PQ  ++ P  +     S P    
Sbjct: 668 PGLASSPEKIVLGQPPSATPTAILTQDSLQ----MFLPQERSQQPLSAEGPHLSVPASVI 723

Query: 294 -SLPPGYQNTTP--PGATG------VPPSSLNYPSGPQAFTQTPLGANHLTTSMSGLSLQ 344
            S PP  Q+  P  P A G       P S  +    PQ     PL     ++S S     
Sbjct: 724 VSAPPPAQDPAPATPVAKGAGLGPQAPDSQASPAPAPQIPAAAPLKGPGPSSSPSLPHQA 783

Query: 345 PEGLRVVNLLQERNMLPST-PLKPP--VPNLHEDIQKLNCNPELFRCTLTSIPQT 396
           P G        +   LPS  P +PP   P+  + + +    P L  C     P T
Sbjct: 784 PLG--------DSPHLPSPHPTRPPSRPPSRPQSVSRPPSEPPLHPCPPPQAPPT 830



 Score = 36.6 bits (83), Expect = 0.13
 Identities = 66/251 (26%), Positives = 91/251 (36%), Gaps = 49/251 (19%)

Query: 7   PASGGAPASLQAQNGAALASGSPYT-----------NGP----VQNALLSSQESVSQGYN 51
           PA GGA  +     GAA  +  P              GP       AL+  Q+ V++  +
Sbjct: 136 PADGGAGPT--GAGGAAAVAAGPQALFPGSTDLLGLQGPPTVLTHQALVPPQDVVNKALS 193

Query: 52  FQLPGSYPHPIPAKTLNPVSG-QSNYGGSQG--SGQTLNRPPVASNPVTPSLHSGPAPRM 108
            Q P   P  +   TL P+ G Q    GS G  +  TL   P+        +   P   +
Sbjct: 194 VQ-PFLQPVGLGNVTLQPIPGLQGLPNGSPGGATAATLGLAPI-------QVVGQPVMAL 245

Query: 109 PLPASQNPATTPMPSSSFLPEANLPPPLNWQYNYPSTASQTNHCPRASS---QPTVSGNT 165
             P SQ  A   +P S +L  A  P       + P T +     P+ +    Q  +S   
Sbjct: 246 NTPTSQLLAKQ-VPVSGYLASAAGP-------SEPVTLASAGVSPQGAGLVIQKNLSAAV 297

Query: 166 SLTTNHQYV---------SSGYPSLQNSFIKSGPSVPPLVNPPLPTTFQPGAPHGPPPAG 216
           + T N   V          +G PS Q   +  G    PLV  P     +   P  P PAG
Sbjct: 298 ATTLNGNSVFGGAGAASAPTGTPSGQPLAVAPGLGSSPLVPAPNVILHRTPTPIQPKPAG 357

Query: 217 G-PPPVRALTP 226
             PP +  LTP
Sbjct: 358 VLPPKLYQLTP 368



 Score = 35.8 bits (81), Expect = 0.23
 Identities = 39/158 (24%), Positives = 56/158 (35%), Gaps = 12/158 (7%)

Query: 13   PASLQAQNGAALASGSPYTNGPVQNALLSSQESVSQGYNFQLPGSYPHPIPAKTLNPVS- 71
            P  L  ++G A   GSP       ++ LSS  S S   +  L      P+P++   P+  
Sbjct: 1243 PTKLVIRHGGA--GGSPSVTWARASSSLSSSSSSSSAAS-SLDADEDGPMPSRNRPPIKT 1299

Query: 72   --GQSNYGGSQGSGQTLNRPPVASNPVTPSLHSGPAPRMPLPASQ---NPATTPMPSSSF 126
               +S  G      Q      V  N     +H  P P   L  ++    P   P P+   
Sbjct: 1300 YEARSRIGLKLKIKQEAGLSKVVHNTALDPVHQPPPPPATLKVAEPPPRPPPPPPPTGQM 1359

Query: 127  LPEANLPPPLNWQYNYPSTASQTNHCPRASSQPTVSGN 164
                + PPP   +     TA    HCPR   + T   N
Sbjct: 1360 NGTVDHPPPAAPERKPLGTAP---HCPRLPLRKTYREN 1394


>gi|116284392 mucin 2 precursor [Homo sapiens]
          Length = 5179

 Score = 57.0 bits (136), Expect = 1e-07
 Identities = 64/260 (24%), Positives = 93/260 (35%), Gaps = 21/260 (8%)

Query: 89   PPVASNPVTPSLHSGPAPRMPLPASQNPATTPMPSSSFLPEANLPPPLNWQYNYPSTASQ 148
            P    +P T +  + P    P P +  P T P  +++  P     PP       P T + 
Sbjct: 1519 PTTTPSPPTTTTTTPPPTTTPSPPTTTPITPPTSTTTLPPTTTPSPPPTTTTTPPPTTTP 1578

Query: 149  TNHCPRASSQPTVSGNT-SLTTNHQYVSSGYPSLQNSFIKSGPSVPPLVNPPLPTTFQPG 207
            +       S PT++  T   TT     ++   +   +   S P+  P+  P   TT  P 
Sbjct: 1579 SPPTTTTPSPPTITTTTPPPTTTPSPPTTTTTTPPPTTTPSPPTTTPITPPTSTTTLPPT 1638

Query: 208  APHGPPP--AGGPPPVRALTPLTSSYRDVPQPLFNSAVNQEGITSNTNNGSMVVHSSYDE 265
                PPP     PPP    +P T++    P P          IT+ T        SS   
Sbjct: 1639 TTPSPPPTTTTTPPPTTTPSPPTTT---TPSP---------PITTTTTPPPTTTPSS--P 1684

Query: 266  IEGGGLLATPQLTNKNPKMSRSVGYSYPSLPPGYQNTTPPGATGVPPSSLNYPSGPQAFT 325
            I       T  +T  +P  + S   +  + P      +PP  T   PS    PS P   T
Sbjct: 1685 ITTTPSPPTTTMTTPSPTTTPSSPITTTTTPSSTTTPSPPPTTMTTPSPTTTPS-PPTTT 1743

Query: 326  QTPLGANHLTTSMSGLSLQP 345
             T L     TT+ S L+  P
Sbjct: 1744 MTTLPP---TTTSSPLTTTP 1760



 Score = 55.5 bits (132), Expect = 3e-07
 Identities = 72/316 (22%), Positives = 101/316 (31%), Gaps = 23/316 (7%)

Query: 59   PHPIPAKTLNPVSGQSNYGGSQGSGQTLNRPPVASNPVTPSLHSGPAPRMPLPASQ-NPA 117
            P P    TL P +  S          T   PP  + P  P   +   P    P+   +  
Sbjct: 1408 PPPTSTTTLPPTTTPSP------PTTTTTTPPPTTTPSPPITTTTTPPPTTTPSPPISTT 1461

Query: 118  TTPMPSSSFLPEANLPPPLNWQYNYPSTASQTNHCPRASSQPTVSGNTSLTTNHQYVSSG 177
            TTP P+++  P    P P     + P+T + T       S PT +  T   +      + 
Sbjct: 1462 TTPPPTTTPSPPTTTPSPPTTTPSPPTTTTTTPPPTTTPSPPTTTPITPPASTTTLPPTT 1521

Query: 178  YPSLQNSFIKSGPSV----PPLVNPPLPTTFQPGAPHGPPPAGGPPPVRALTPLTSSYRD 233
             PS   +   + P      PP   P  P T     P  P     PPP    TP  ++   
Sbjct: 1522 TPSPPTTTTTTPPPTTTPSPPTTTPITPPTSTTTLP--PTTTPSPPPTTTTTPPPTT--- 1576

Query: 234  VPQPLFNSAVNQEGITSNTNNGSMVVHSSYDEIEGGGLLATPQLTNKNPKMSRSVGYSYP 293
             P P   +  +   IT+ T   +                 TP      P    +   + P
Sbjct: 1577 TPSPPTTTTPSPPTITTTTPPPTTTPSPPTTTTTTPPPTTTPSPPTTTPITPPTSTTTLP 1636

Query: 294  SL----PPGYQNTTPPGATGVPPSSLNYPSGPQAFTQTPLGANHLTTSMSGLSLQPEGLR 349
                  PP    TTPP  T   P +   PS P   T TP      TT  S ++  P    
Sbjct: 1637 PTTTPSPPPTTTTTPPPTTTPSPPTTTTPSPPITTTTTP---PPTTTPSSPITTTPSPPT 1693

Query: 350  VVNLLQERNMLPSTPL 365
                       PS+P+
Sbjct: 1694 TTMTTPSPTTTPSSPI 1709



 Score = 42.7 bits (99), Expect = 0.002
 Identities = 54/248 (21%), Positives = 82/248 (33%), Gaps = 20/248 (8%)

Query: 109  PLPASQNPATTPMPSSSFLPEANLPPPLNWQYNYPST-------ASQTNHCPRASSQPTV 161
            P P +  P+  P  +++  P     PP       P T        + T   P  +  P +
Sbjct: 1399 PSPPTTTPSPPPTSTTTLPPTTTPSPPTTTTTTPPPTTTPSPPITTTTTPPPTTTPSPPI 1458

Query: 162  SGNT----SLTTNHQYVSSGYPSLQNSFIKSGPSVPPLVNPPLPTTFQPGAPHGPPPAGG 217
            S  T    + T +    +   P+   S   +  + PP    P P T  P  P  P     
Sbjct: 1459 STTTTPPPTTTPSPPTTTPSPPTTTPSPPTTTTTTPPPTTTPSPPTTTPITP--PASTTT 1516

Query: 218  PPPVRALTPLTSSYRDVPQPLFNSAVNQEGITSNTNNGSMVVHSSYDEIEGGGLLATPQL 277
             PP    +P T++    P     S      IT  T+  ++   ++            P  
Sbjct: 1517 LPPTTTPSPPTTTTTTPPPTTTPSPPTTTPITPPTSTTTLPPTTTPSPPPTTTTTPPPTT 1576

Query: 278  TNKNPKMSRSVGYSYPSLPPGYQNTTPPGATGVPPSSLNYPSGPQAFTQTPLGANHLTTS 337
            T   P  +       PS PP    TTPP  T   P +    + P   T +P     +T  
Sbjct: 1577 TPSPPTTTT------PS-PPTITTTTPPPTTTPSPPTTTTTTPPPTTTPSPPTTTPITPP 1629

Query: 338  MSGLSLQP 345
             S  +L P
Sbjct: 1630 TSTTTLPP 1637



 Score = 40.8 bits (94), Expect = 0.007
 Identities = 68/304 (22%), Positives = 104/304 (34%), Gaps = 35/304 (11%)

Query: 85   TLNRPPVASNPVTPSLHSGPAPRMPLPASQNPATTPM--------PSSSFLPEANLPPPL 136
            T   PP  + P +P + + P+P      + +P TTP         PSS+  P    PPP 
Sbjct: 1671 TTTTPPPTTTPSSP-ITTTPSPPTTTMTTPSPTTTPSSPITTTTTPSSTTTPS---PPPT 1726

Query: 137  NWQYNYPSTASQTNHCPRASSQPTVSGNTSLTTNHQYVSSGYPSLQNSFIKSGPSVP--P 194
                  P+T          +  PT + +   TT      S  P   + F  + P+ P  P
Sbjct: 1727 TMTTPSPTTTPSPPTTTMTTLPPTTTSSPLTTT--PLPPSITPPTFSPFSTTTPTTPCVP 1784

Query: 195  LVNPPLPTTFQPGAPHGPPPAG---------GPPPVRALTPLTSSYRDVPQPLFNSAVNQ 245
            L N         G P+   P G         GP     ++   + Y DVP       + Q
Sbjct: 1785 LCN--WTGWLDSGKPNFHKPGGDTELIGDVCGPGWAANISCRATMYPDVP-------IGQ 1835

Query: 246  EGITSNTNNGSMVVHSSYDEIEGGGLLATPQLTNK-NPKMSRSVGYSYPSLPPGYQNTTP 304
             G T   +    ++  + D+  GG +     L  + N +    V           +N TP
Sbjct: 1836 LGQTVVCDVSVGLICKNEDQKPGGVIPMAFCLNYEINVQCCECVTQPTTMTTTTTENPTP 1895

Query: 305  PGATGVPPSSLNYPSGPQAFTQTPLGANHLTTSMSGLSLQPEGLRVVNLLQERNMLPSTP 364
            P  T +  ++   P+     TQTP      TT+    +  P G +             TP
Sbjct: 1896 PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTP 1955

Query: 365  LKPP 368
               P
Sbjct: 1956 TPTP 1959



 Score = 36.6 bits (83), Expect = 0.13
 Identities = 62/317 (19%), Positives = 106/317 (33%), Gaps = 38/317 (11%)

Query: 59   PHPIPAKTLNPVSGQSNYGGSQGSGQTLNRPPVASNPVTPSLHSGPAPRMPLPASQNPAT 118
            P   P  T   V+      G+Q    T   P   +  VTP+    P P      +Q P T
Sbjct: 4035 PTTTPITTTTTVTPTPTPTGTQTPTTT---PITTTTTVTPT----PTPT----GTQTPTT 4083

Query: 119  TPMPSSSFLPEANLPPPLNWQYNYPSTASQT---NHCPRASSQPTVSGNTSLTT-NHQYV 174
            TP+ +++ +     P         P T + T      P  +  PT +  T+ TT      
Sbjct: 4084 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 4143

Query: 175  SSGYPSLQNSFIKSGPSVPPLVNPP-------LPTTFQPGAPHGPPPAG---GPPPVRAL 224
             +G  +   + I +  +V P   P         P T        P P G   GPP   + 
Sbjct: 4144 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTGPPTHTST 4203

Query: 225  TPLTSSYRDVPQPLFNSAVNQEGITSNTNNGSMVVHSSYDEIEGGGLLATPQLTNKNPKM 284
             P+       P P  ++       +S     + ++ +    IE         +T+  P  
Sbjct: 4204 APIAELTTSNPPPESSTPQTSRSTSSPLTESTTLLSTLPPAIE---------MTSTAPPS 4254

Query: 285  SRSVGYSYPSLPPGYQNTTPPGATGVPPSSLNYPSGPQAFTQTPLGANHLTTSMSGLSLQ 344
            + +     P+   G    +PP +T   P            +  P  +   TT+ S  +  
Sbjct: 4255 TPTA----PTTTSGGHTLSPPPSTTTSPPGTPTRGTTTGSSSAPTPSTVQTTTTSAWTPT 4310

Query: 345  PEGLRVVNLLQERNMLP 361
            P  L   ++++   + P
Sbjct: 4311 PTPLSTPSIIRTTGLRP 4327



 Score = 32.7 bits (73), Expect = 1.9
 Identities = 55/237 (23%), Positives = 81/237 (34%), Gaps = 37/237 (15%)

Query: 2    SQPGIPA-SGGAPASLQAQNGAALASGSPYTNGPVQNALLSSQESVSQGYNFQLPGSYPH 60
            +Q G P  +  AP +    +     S +P T+    + L  S   +S      LP +   
Sbjct: 4193 TQTGPPTHTSTAPIAELTTSNPPPESSTPQTSRSTSSPLTESTTLLST-----LPPAIEM 4247

Query: 61   PIPAKTLNPVSGQSNYGGSQGSGQTLNRPP--VASNPVTPSL------HSGPAP---RMP 109
               A    P +  +  GG      TL+ PP    S P TP+        S P P   +  
Sbjct: 4248 TSTAPPSTPTAPTTTSGG-----HTLSPPPSTTTSPPGTPTRGTTTGSSSAPTPSTVQTT 4302

Query: 110  LPASQNPATTPMPSSSFLPEANLPPPLNWQYNYPSTA------SQTNHCPRASSQPTVSG 163
              ++  P  TP+ + S +    L P       YPS+       + T + P         G
Sbjct: 4303 TTSAWTPTPTPLSTPSIIRTTGLRP-------YPSSVLICCVLNDTYYAPGEEVYNGTYG 4355

Query: 164  NTSLTTNHQYVSSGYPSLQNSFIKSGPSVPPLVNPPLPTTFQPGAPHGPPPAGGPPP 220
            +T    N     S      N    S PS  P  +   PT  +P +    P  G  PP
Sbjct: 4356 DTCYFVNCSL--SCTLEFYNWSCPSTPSPTPTPSKSTPTPSKPSSTPSKPTPGTKPP 4410


>gi|34365793 WNK lysine deficient protein kinase 4 [Homo sapiens]
          Length = 1243

 Score = 56.2 bits (134), Expect = 2e-07
 Identities = 70/298 (23%), Positives = 106/298 (35%), Gaps = 51/298 (17%)

Query: 2    SQPGIPASGGAPASLQAQNGAALASGSPYTNGPVQNALLSSQESVSQGYNFQLPGSYPHP 61
            S PG P S G P S           G+P + GP+              +    P  +P P
Sbjct: 805  SSPGTPLSPGNPFS----------PGTPISPGPI--------------FPITSPPCHPSP 840

Query: 62   IPAKTLNPVSGQSNYGGSQGSGQTLNRPPVASNPVTPSLHSGPAPRMPLPASQNPATTPM 121
             P    +P+S       SQ S      P  +  P + S    P P    P S  P T+P 
Sbjct: 841  SP---FSPIS-------SQVSSNPSPHPTSSPLPFSSSTPEFPVPLSQCPWSSLPTTSPP 890

Query: 122  PSSSFLPEANLPPPLNWQYNYPSTASQTNHCPRASSQPTVSGNTSLTTNHQYVSSGYPSL 181
              S    +  L  P      +P   S T+  P  ++ P +S  ++ +     V+    S 
Sbjct: 891  TFSPTCSQVTLSSPF-----FPPCPS-TSSFPSTTAAPLLSLASAFSLAVMTVAQSLLSP 944

Query: 182  QNSFIKSGPSVP--PLVNPPLPTTFQPGAPHGPPP-------AGGPPPVRALTPLTSSYR 232
                +   P  P  PL + PLP    PG    P P          PPP R L P  +   
Sbjct: 945  SPGLLSQSPPAPPSPLPSLPLPPPVAPGGQESPSPHTAEVESEASPPPARPL-PGEARLA 1003

Query: 233  DVPQPLFNSAVNQEGITSNTNNGS-MVVHSSYDEIEGGGLLATPQLTNKNPKMSRSVG 289
             + +      V +  +TS+      + +  +   + G    +TPQLT+++     S G
Sbjct: 1004 PISEEGKPQLVGRFQVTSSKEPAEPLPLQPTSPTLSGSPKPSTPQLTSESSDTEDSAG 1061


>gi|125858485 hypothetical protein LOC80209 isoform 2 [Homo sapiens]
          Length = 922

 Score = 54.7 bits (130), Expect = 5e-07
 Identities = 92/339 (27%), Positives = 124/339 (36%), Gaps = 50/339 (14%)

Query: 29  PYTNGPV--QNALLSSQESVSQGYNFQLPGSY-----------PHPIPAKTLNPVSGQSN 75
           PYT  PV  +N  LS+     Q   F  P S            P   P  T +PV   ++
Sbjct: 213 PYTPNPVGTENEDLSNPSKPIQNQTFSTPASQLFSPHGSNPSTPAATPVPTASPVKAINH 272

Query: 76  YGGSQG---SGQTLNRP--PVASNPVTPSLHSGPAPRMPLP--------------ASQNP 116
              S     SG  L     PV    V+ ++H+ P P +P P              +  + 
Sbjct: 273 PSASAAATVSGMNLLNTVLPVFPGQVSSAVHT-PQPSIPNPTVIRTPSLPTAPVTSIHST 331

Query: 117 ATTPMPSSSFLPEANLPPPLNWQYNYPSTASQTNHCPRASSQPTVSGNTSLTTNHQYVSS 176
            TTP+PS  F    +LP P         T   T      SS+   S +   T+     SS
Sbjct: 332 TTTPVPSI-FSGLVSLPGPSATPTAATPTPGPTPRSTLGSSEAFASTSAPFTSLPFSTSS 390

Query: 177 GYPSLQNSFIKSGPSVPPLVNPPLPTTFQPGAPHGPPPAGGPPPVRALTPLTSSYRDVPQ 236
              S  N    S  SV   +  PLP T Q  +   P  AGG       TP  +    V  
Sbjct: 391 SAASTSNPNSASLSSVFAGLPLPLPPTSQGLSNPTPVIAGGS------TPSVAGPLGVNS 444

Query: 237 PLFNSAVNQEGITSNTNNGSMVVHSSYDEIEGGGLLATPQLTNKNPKMSRSVGYS--YPS 294
           PL ++   +  +TSN  N  ++  S+       GL +   LT +N   S S       PS
Sbjct: 445 PLLSAL--KGFLTSNDTN--LINSSALSSAVTSGLASLSSLTLQNSDSSASAPNKCYAPS 500

Query: 295 LPPGYQNTTPPGAT---GVPPSSLNYPSGPQAF-TQTPL 329
             P  Q T+ PG     G+P    N  S P     Q+PL
Sbjct: 501 AIPTPQRTSTPGLALFPGLPSPVANSTSTPLTLPVQSPL 539


>gi|125656155 hypothetical protein LOC80209 isoform 1 [Homo sapiens]
          Length = 944

 Score = 54.7 bits (130), Expect = 5e-07
 Identities = 92/339 (27%), Positives = 124/339 (36%), Gaps = 50/339 (14%)

Query: 29  PYTNGPV--QNALLSSQESVSQGYNFQLPGSY-----------PHPIPAKTLNPVSGQSN 75
           PYT  PV  +N  LS+     Q   F  P S            P   P  T +PV   ++
Sbjct: 235 PYTPNPVGTENEDLSNPSKPIQNQTFSTPASQLFSPHGSNPSTPAATPVPTASPVKAINH 294

Query: 76  YGGSQG---SGQTLNRP--PVASNPVTPSLHSGPAPRMPLP--------------ASQNP 116
              S     SG  L     PV    V+ ++H+ P P +P P              +  + 
Sbjct: 295 PSASAAATVSGMNLLNTVLPVFPGQVSSAVHT-PQPSIPNPTVIRTPSLPTAPVTSIHST 353

Query: 117 ATTPMPSSSFLPEANLPPPLNWQYNYPSTASQTNHCPRASSQPTVSGNTSLTTNHQYVSS 176
            TTP+PS  F    +LP P         T   T      SS+   S +   T+     SS
Sbjct: 354 TTTPVPSI-FSGLVSLPGPSATPTAATPTPGPTPRSTLGSSEAFASTSAPFTSLPFSTSS 412

Query: 177 GYPSLQNSFIKSGPSVPPLVNPPLPTTFQPGAPHGPPPAGGPPPVRALTPLTSSYRDVPQ 236
              S  N    S  SV   +  PLP T Q  +   P  AGG       TP  +    V  
Sbjct: 413 SAASTSNPNSASLSSVFAGLPLPLPPTSQGLSNPTPVIAGGS------TPSVAGPLGVNS 466

Query: 237 PLFNSAVNQEGITSNTNNGSMVVHSSYDEIEGGGLLATPQLTNKNPKMSRSVGYS--YPS 294
           PL ++   +  +TSN  N  ++  S+       GL +   LT +N   S S       PS
Sbjct: 467 PLLSAL--KGFLTSNDTN--LINSSALSSAVTSGLASLSSLTLQNSDSSASAPNKCYAPS 522

Query: 295 LPPGYQNTTPPGAT---GVPPSSLNYPSGPQAF-TQTPL 329
             P  Q T+ PG     G+P    N  S P     Q+PL
Sbjct: 523 AIPTPQRTSTPGLALFPGLPSPVANSTSTPLTLPVQSPL 561


>gi|116284398 WAS/WASL interacting protein family, member 1 [Homo
           sapiens]
          Length = 503

 Score = 53.5 bits (127), Expect = 1e-06
 Identities = 93/351 (26%), Positives = 119/351 (33%), Gaps = 102/351 (29%)

Query: 55  PGSYPHPIPAKTLNPVSGQSNYGGSQGSGQTLNRPPVASNPVTPSLHSGPAPRMPLPASQ 114
           P S P P+P+ T  P+    +  GS         PPV   P  PS   GP P  P P ++
Sbjct: 180 PDSIPPPVPS-TPRPIQSSPHNRGS---------PPVPGGPRQPS--PGPTPP-PFPGNR 226

Query: 115 NPAT-------TPMPSSSFLPEANLPPPLNWQYNYPSTASQTNHCPRASSQPTVSGNTSL 167
             A        +P+ SSS  P +N PP        P T S+          P V      
Sbjct: 227 GTALGGGSIRQSPLSSSS--PFSNRPP-------LPPTPSRALDDKPPPPPPPVGNR--- 274

Query: 168 TTNHQYVSSGYPSLQNSFIKSGPSVPPLVN-PPLPTTFQPGAPHGPPPAGGPPPVRALTP 226
                      PS+    +   P  PP  N PP+P+T +P A    PP   PP       
Sbjct: 275 -----------PSIHREAV---PPPPPQNNKPPVPSTPRPSASSQAPPPPPPPS------ 314

Query: 227 LTSSYRDVPQPLFNSAVNQEGITSNTNNGSMVVHSSYDEIEGGGLLATPQLTNKNPKMSR 286
                R  P PL  S+                  S  DE        TP+L  +N  +S 
Sbjct: 315 -----RPGPPPLPPSS------------------SGNDE--------TPRLPQRNLSLSS 343

Query: 287 SVGYSYPSLP-PGYQNTTPPGATGVPPSSLNYP---SGP---------QAFTQTPLGANH 333
           S     P LP PG     PP  +  PP  +  P   SGP            T   L A  
Sbjct: 344 ST----PPLPSPGRSGPLPPPPSERPPPPVRDPPGRSGPLPPPPPVSRNGSTSRALPATP 399

Query: 334 LTTSMSGLSLQPEGLRVVNLLQERNMLPSTPLKPPVPNLHEDIQKLNCNPE 384
              S SG+     G R   L  +R    + P  PP  ++    Q   C  E
Sbjct: 400 QLPSRSGVDSPRSGPR-PPLPPDRPSAGAPPPPPPSTSIRNGFQDSPCEDE 449


>gi|38373695 WAS/WASL interacting protein family, member 1 [Homo
           sapiens]
          Length = 503

 Score = 53.5 bits (127), Expect = 1e-06
 Identities = 93/351 (26%), Positives = 119/351 (33%), Gaps = 102/351 (29%)

Query: 55  PGSYPHPIPAKTLNPVSGQSNYGGSQGSGQTLNRPPVASNPVTPSLHSGPAPRMPLPASQ 114
           P S P P+P+ T  P+    +  GS         PPV   P  PS   GP P  P P ++
Sbjct: 180 PDSIPPPVPS-TPRPIQSSPHNRGS---------PPVPGGPRQPS--PGPTPP-PFPGNR 226

Query: 115 NPAT-------TPMPSSSFLPEANLPPPLNWQYNYPSTASQTNHCPRASSQPTVSGNTSL 167
             A        +P+ SSS  P +N PP        P T S+          P V      
Sbjct: 227 GTALGGGSIRQSPLSSSS--PFSNRPP-------LPPTPSRALDDKPPPPPPPVGNR--- 274

Query: 168 TTNHQYVSSGYPSLQNSFIKSGPSVPPLVN-PPLPTTFQPGAPHGPPPAGGPPPVRALTP 226
                      PS+    +   P  PP  N PP+P+T +P A    PP   PP       
Sbjct: 275 -----------PSIHREAV---PPPPPQNNKPPVPSTPRPSASSQAPPPPPPPS------ 314

Query: 227 LTSSYRDVPQPLFNSAVNQEGITSNTNNGSMVVHSSYDEIEGGGLLATPQLTNKNPKMSR 286
                R  P PL  S+                  S  DE        TP+L  +N  +S 
Sbjct: 315 -----RPGPPPLPPSS------------------SGNDE--------TPRLPQRNLSLSS 343

Query: 287 SVGYSYPSLP-PGYQNTTPPGATGVPPSSLNYP---SGP---------QAFTQTPLGANH 333
           S     P LP PG     PP  +  PP  +  P   SGP            T   L A  
Sbjct: 344 ST----PPLPSPGRSGPLPPPPSERPPPPVRDPPGRSGPLPPPPPVSRNGSTSRALPATP 399

Query: 334 LTTSMSGLSLQPEGLRVVNLLQERNMLPSTPLKPPVPNLHEDIQKLNCNPE 384
              S SG+     G R   L  +R    + P  PP  ++    Q   C  E
Sbjct: 400 QLPSRSGVDSPRSGPR-PPLPPDRPSAGAPPPPPPSTSIRNGFQDSPCEDE 449


>gi|31543543 retinoic acid induced 17 [Homo sapiens]
          Length = 1067

 Score = 53.1 bits (126), Expect = 1e-06
 Identities = 67/235 (28%), Positives = 87/235 (37%), Gaps = 32/235 (13%)

Query: 1   MSQPGI--PASGGA---PASLQAQNGAALASGSPYTNGPVQNALLSSQESVSQGYNFQL- 54
           M+QPG   PAS G    PAS+ A    +  SG P      +   +S   +  Q    Q  
Sbjct: 331 MNQPGPRGPASMGGSMNPASMAAGMTPSGMSGPPMGMNQPRPPGISPFGTHGQRMPQQTY 390

Query: 55  PGSYPHPIPAKTLN-PVSGQSNYGGSQGSGQTLNRPPVASNPVTPSLHSGPAPRMPLPAS 113
           PG  P  +P + +  P  G+ NYG  Q         P +  P  P  +  P P  PL + 
Sbjct: 391 PGPRPQSLPIQNIKRPYPGEPNYGNQQYG-------PNSQFPTQPGQYPAPNPPRPLTSP 443

Query: 114 QNPATT--PMPSSSFLPEANLPPPLNW-QYNYPSTASQTNHCPRASSQPTVS-GNTSLTT 169
             P       PSS   P    PP +N  QY  P   +  N+    SS    S GN +   
Sbjct: 444 NYPGQRMPSQPSSGQYP----PPTVNMGQYYKPEQFNGQNNTFSGSSYSNYSQGNVNRPP 499

Query: 170 NH----QYVSSGYPSLQNSFIKSGPSVPPL------VNPPLPTTFQPGAPHGPPP 214
                  Y  S  P      +  G S+PP       V PP P   +P     PPP
Sbjct: 500 RPVPVANYPHSPVPGNPTPPMTPGSSIPPYLSPSQDVKPPFPPDIKPNMSALPPP 554



 Score = 32.0 bits (71), Expect = 3.3
 Identities = 77/360 (21%), Positives = 118/360 (32%), Gaps = 50/360 (13%)

Query: 27  GSPYTNG-PVQNALLSSQESVSQGYNFQLPGSYPHPIPAKTLNPVSGQSNYGGSQGSGQT 85
           G+P  +G    N  L+S +   Q   F        P   +++    G+ NY GS G G +
Sbjct: 197 GNPMASGMTTSNPGLNSPQFAGQQQQFSAKAGPAQPYIQQSMY---GRPNYPGSGGFGAS 253

Query: 86  LNRPPVASNPVTPSLHSGPAPRMPLPASQ------NPATTPMPSSSFLPEANLPPPLNWQ 139
               P A   +    H+ P      PA+         A     +++    A L    N  
Sbjct: 254 YPGGPNAPAGMGIPPHTRPPADFTQPAAAAAAAAVAAAAATATATATATVAALQETQNKD 313

Query: 140 YN-YPSTASQTNHCPRASSQPTVSGNTSLTTNHQYVSSGYPSLQNSFIKSGPSVPPL-VN 197
            N Y        +  +  +QP   G  S+       S    S+      SG S PP+ +N
Sbjct: 314 INQYGPMGPTQAYNSQFMNQPGPRGPASMGG-----SMNPASMAAGMTPSGMSGPPMGMN 368

Query: 198 PPLPTTFQPGAPHGP--PPAGGPPPVRALTPLTSSYRDVPQPLFNSAVNQEGITSNTNNG 255
            P P    P   HG   P    P P     P+ +  R  P               N  N 
Sbjct: 369 QPRPPGISPFGTHGQRMPQQTYPGPRPQSLPIQNIKRPYPG------------EPNYGNQ 416

Query: 256 SMVVHSSYDEIEGGGLLATPQLTNKNPKMSRSVGYSYPSLPPGYQNTTPPGATGVPPSSL 315
               +S +    G      P      P+   S  Y      PG +  + P +   PP ++
Sbjct: 417 QYGPNSQFPTQPGQYPAPNP------PRPLTSPNY------PGQRMPSQPSSGQYPPPTV 464

Query: 316 NYPS--GPQAF---TQTPLGANHLTTSMSGLSLQPEGLRVVNLLQERNMLPSTPLKPPVP 370
           N      P+ F     T  G+++   S   ++  P  + V N     + +P  P  P  P
Sbjct: 465 NMGQYYKPEQFNGQNNTFSGSSYSNYSQGNVNRPPRPVPVAN--YPHSPVPGNPTPPMTP 522


>gi|153945878 mucin 5, subtype B, tracheobronchial [Homo sapiens]
          Length = 5765

 Score = 52.0 bits (123), Expect = 3e-06
 Identities = 76/305 (24%), Positives = 108/305 (35%), Gaps = 28/305 (9%)

Query: 62   IPAKTLNPVSGQSNYGGSQGSGQTLNRPPVASNPVTPSLHSGPAPRMPLPASQNPATTPM 121
            +P  +    S      G+     T   P V S+  TP   S P     LPA ++ ATTP 
Sbjct: 3736 VPTGSTATASSTQATAGTPHVSTTATTPTVTSSKATP--FSSPGTATALPALRSTATTPT 3793

Query: 122  PSS-SFLPEANLPPPLNW-QYNYPSTASQTNHCPRASSQPTVSGNTSLTTNHQYVSSGYP 179
             +S + +P ++L     W + +  +T + T      SS P  +  +++ T     +    
Sbjct: 3794 ATSFTAIPSSSL--GTTWTRLSQTTTPTATMSTATPSSTPETAHTSTVLTTTATTTRATG 3851

Query: 180  SLQNSFIKSGPSVPPLVNPPLPTTFQPGAPHGPPPAGGPPPV---RALTPLTSSYRDVPQ 236
            S+       G +    V P   TT     P   P     PPV      TP TS     P 
Sbjct: 3852 SVATPSSTPGTAHTTKV-PTTTTTGFTVTPSSSPGTARTPPVWISTTTTPTTSGSTVTPS 3910

Query: 237  PLFNSAVNQEGITSNTN---NGSMVVHSSYDEIEGGGLLATPQLTNKNPKMSRSVGYSYP 293
             +  +      +T+ T     GSM   SS  +  G      P L      ++ +   + P
Sbjct: 3911 SVPGTTHTPTVLTTTTTTVATGSMATPSSSTQTSG----TPPSLITTATTITATGSTTNP 3966

Query: 294  SLPPGYQNTTP-------PGATGVPPSSLNYPSGPQAFTQTPLGANHLTTSMSGLSLQPE 346
            S  PG   TTP          T    SS   PS     T TP   N  T +  G SL P 
Sbjct: 3967 SSTPG---TTPIPPVLTTTATTPAATSSTVTPSSALGTTHTPPVPN-TTATTHGRSLSPS 4022

Query: 347  GLRVV 351
                V
Sbjct: 4023 SPHTV 4027



 Score = 51.2 bits (121), Expect = 5e-06
 Identities = 73/282 (25%), Positives = 104/282 (36%), Gaps = 28/282 (9%)

Query: 85   TLNRPPVASNPVTPSLHSGPAPRMPLPASQNPATTPMPSS-SFLPEANLPPPLNW-QYNY 142
            T   P V S+  TPS  S P     LPA ++ ATTP  +S + +P ++L     W + + 
Sbjct: 1945 TATTPTVTSSKATPS--SSPGTATALPALRSTATTPTATSVTPIPSSSL--GTTWTRLSQ 2000

Query: 143  PSTASQTNHCPRASSQPTVSGNTSLTTNHQYVSSGYPSLQNSFIKSGPSVPPLVNPPLPT 202
             +T + T      SS P  +  +++ T     +    S+       G +    V P   T
Sbjct: 2001 TTTPTATMSTATPSSTPETAHTSTVLTATATTTGATGSVATPSSTPGTAHTTKV-PTTTT 2059

Query: 203  TFQPGAPHGPPPAGGPPPV---RALTPLTSSYRDVPQPLFNSAVNQEGITSNTN---NGS 256
            T     P   P     PPV      TP T      P  +  +      +T+ T     GS
Sbjct: 2060 TGFTATPSSSPGTALTPPVWISTTTTPTTRGSTVTPSSIPGTTHTATVLTTTTTTVATGS 2119

Query: 257  MVVHSSYDEIEGGGLLATPQLTNKNPKMSRSVGYSYPSLPPGYQNTTP-------PGATG 309
            M   SS  +  G      P LT     ++ +   + PS  PG   TTP          T 
Sbjct: 2120 MATPSSSTQTSG----TPPSLTTTATTITATGSTTNPSSTPG---TTPIPPVLTTTATTP 2172

Query: 310  VPPSSLNYPSGPQAFTQTPLGANHLTTSMSGLSLQPEGLRVV 351
               S+   PS     T TP   N + T+  G SL P     V
Sbjct: 2173 AATSNTVTPSSALGTTHTPPVPNTMATT-HGRSLPPSSPHTV 2213



 Score = 50.8 bits (120), Expect = 7e-06
 Identities = 76/283 (26%), Positives = 104/283 (36%), Gaps = 30/283 (10%)

Query: 85   TLNRPPVASNPVTPSLHSGPAPRMPLPASQNPATTPMPSS-SFLPEANLPPPLNWQYNYP 143
            T   P V S+  TPS  S P     LPA ++ ATTP  +S + +P ++L      + +  
Sbjct: 3202 TATTPTVISSRATPS--SSPGTATALPALRSTATTPTATSVTAIPSSSLGTAWT-RLSQT 3258

Query: 144  STASQTNHCPRASSQP-TVSGNTSLTTNHQYVSSGYPSLQNSFIKSGPSVPPLVNPP-LP 201
            +T + T      SS P TV  +T LTT      +         + +  S P   +   +P
Sbjct: 3259 TTPTATMSTATPSSTPETVHTSTVLTTTTTTTRA------TGSVATPSSTPGTAHTTKVP 3312

Query: 202  TTFQPG---APHGPPPAGGPPPV---RALTPLTSSYRDVPQPLFNSAVNQEGITSNTNN- 254
            TT   G    P   P     PPV      TP T      P  +  +      +T+ T   
Sbjct: 3313 TTTTTGFTATPSSSPGTALTPPVWISTTTTPTTRGSTVTPSSIPGTTHTATVLTTTTTTV 3372

Query: 255  --GSMVVHSSYDEIEGGGLLATPQLTNKNPKMSRSVGYSYPSLPPGYQNTTP----PGAT 308
              GSM   SS  +  G      P LT     ++ +   + PS  PG     P       T
Sbjct: 3373 ATGSMATPSSSTQTSG----TPPSLTTTATTITATGSTTNPSSTPGTTPIPPVLTTTATT 3428

Query: 309  GVPPSSLNYPSGPQAFTQTPLGANHLTTSMSGLSLQPEGLRVV 351
                SS   PS     T TP   N  T +  G SL P     V
Sbjct: 3429 PAATSSTVTPSSALGTTHTPPVPN-TTATTHGRSLPPSSPHTV 3470



 Score = 50.8 bits (120), Expect = 7e-06
 Identities = 72/297 (24%), Positives = 105/297 (35%), Gaps = 33/297 (11%)

Query: 62   IPAKTLNPVSGQSNYGGSQGSGQTLNRPPVASNPVTPSLHSGPAPRMPLPASQNPATTPM 121
            +P  +    S      G+     T   P V S+  TPS  S P     LPA ++ ATTP 
Sbjct: 4464 VPTGSTATASSTQATAGTPHVSTTATTPTVTSSKATPS--SSPGTATALPALRSTATTPT 4521

Query: 122  PSS-SFLPEANLPPPLNW-QYNYPSTASQTNHCPRASSQPTVSGNTSLTTNHQYVSSGYP 179
             +S + +P ++L     W + +  +T + T      SS P     +++ T     +    
Sbjct: 4522 ATSFTAIPSSSL--GTTWTRLSQTTTPTATMSTATPSSTPETVHTSTVLTATATTTGATG 4579

Query: 180  SLQNSFIKSGPSVPPLVNPPLPTTFQPGAPHGPPPAGGPPPV--------RALTPLTSSY 231
            S+       G +    V P   TT     P   P     PPV           TP TS  
Sbjct: 4580 SVATPSSTPGTAHTTKV-PTTTTTGFTATPSSSPGTALTPPVWISTTTTPTTTTPTTSGS 4638

Query: 232  RDVPQPLFNSAVNQEGITSNTN---NGSMVVHSSYDEIEGGGLLATPQLTNKNPKMSRSV 288
               P  +  +      +T+ T     GSM   SS  +  G      P LT     ++ + 
Sbjct: 4639 TVTPSSIPGTTHTARVLTTTTTTVATGSMATPSSSTQTSG----TPPSLTTTATTITATG 4694

Query: 289  GYSYPSLPPGYQNTTP--------PGATGVPPSSLNYPSGPQAFTQTPLGANHLTTS 337
              + PS  PG    TP        P AT    S     S P+  T  P+  +  T S
Sbjct: 4695 STTNPSSTPGTTPITPVLTSTATTPAATS---SKATSSSSPRTATTLPVLTSTATKS 4748



 Score = 47.8 bits (112), Expect = 6e-05
 Identities = 77/304 (25%), Positives = 109/304 (35%), Gaps = 26/304 (8%)

Query: 62   IPAKTLNPVSGQSNYGGSQGSGQTLNRPPVASNPVTPSLHSGPAPRMPLPASQNPATTPM 121
            +P  +    S      G+     T   P V S+  TP   S P     LPA ++ ATTP 
Sbjct: 2479 VPTGSTATASSTQATAGTPHVSTTATTPTVTSSKATP--FSSPGTATALPALRSTATTPT 2536

Query: 122  PSS-SFLPEANLPPPLNW-QYNYPSTASQTNHCPRASSQP-TVSGNTSLTTNHQYV-SSG 177
             +S + +P ++L     W + +  +T + T      SS P TV  +T LTT      ++G
Sbjct: 2537 ATSFTAIPSSSLGT--TWTRLSQTTTPTATMSTATPSSTPETVHTSTVLTTTATTTGATG 2594

Query: 178  YPSLQNSFIKSGPSVPPLVNPPLPTTFQPGAPHGPPPAGGPPPV---RALTPLTSSYRDV 234
              +  +S   +  +   L      TT     P   P      PV      TP T      
Sbjct: 2595 SVATPSSTPGTAHTTKVLTTT---TTGFTATPSSSPGTARTLPVWISTTTTPTTRGSTVT 2651

Query: 235  PQPLFNSAVNQEGITSNTNN---GSMVVHSSYDEIEGGGLLATPQLTNKNPKMSRSVGYS 291
            P  +  +      +T+ T     GSM   SS  +  G      P LT     ++ +   +
Sbjct: 2652 PSSIPGTTHTPTVLTTTTTTVATGSMATPSSSTQTSG----TPPSLTTTATTITATGSTT 2707

Query: 292  YPSLPPGYQNTTP----PGATGVPPSSLNYPSGPQAFTQTPLGANHLTTSMSGLSLQPEG 347
             PS  PG     P       T    SS   PS     T TP   N  T +  G SL P  
Sbjct: 2708 NPSSTPGTTPIPPVLTTTATTPAATSSTVTPSSALGTTHTPPVPN-TTATTHGRSLSPSS 2766

Query: 348  LRVV 351
               V
Sbjct: 2767 PHTV 2770



 Score = 44.7 bits (104), Expect = 5e-04
 Identities = 74/330 (22%), Positives = 108/330 (32%), Gaps = 48/330 (14%)

Query: 64   AKTLNPVSGQSNYGGSQGSGQTLNRPPVASNPVTPSLHSGPAPRMPLPASQNPATTPMPS 123
            A T       +    + G+  T   P   +   T +  S P      P   +  TTP  S
Sbjct: 3844 ATTTRATGSVATPSSTPGTAHTTKVPTTTTTGFTVTPSSSPGTARTPPVWISTTTTPTTS 3903

Query: 124  SSFLPEANLPPPLNWQYNYPSTASQTNHCPRASSQPTVSGNTSLTTNHQYVSSGYPSLQN 183
             S +               PS+   T H P           T LTT    V++G  +  +
Sbjct: 3904 GSTVT--------------PSSVPGTTHTP-----------TVLTTTTTTVATGSMATPS 3938

Query: 184  SFIKSGPSVPPLVNPPLPTTFQPGAPHGPPPAGGPPPV------RALTPLTSSYRDVP-Q 236
            S  ++  + P L+      T   G+   P    G  P+       A TP  +S    P  
Sbjct: 3939 SSTQTSGTPPSLITTATTIT-ATGSTTNPSSTPGTTPIPPVLTTTATTPAATSSTVTPSS 3997

Query: 237  PLFNSAVNQEGITSNTNNGSMVVHSSYDEIEGGGLLATPQLTNKNPKMSRSVGYSY-PSL 295
             L  +       T+ T +G  +  SS   +      AT            S G S+ P+ 
Sbjct: 3998 ALGTTHTPPVPNTTATTHGRSLSPSSPHTVRTAWTSATSGTLGTTHITEPSTGTSHTPAA 4057

Query: 296  PPGYQNTTPPGATGVPPSSLNYPSGPQAFTQTPLGANHLT-TSMSGLSLQPEGLRVVNLL 354
              G    + P  +   PSS    S P   T TP    H T TS +  +  P   R   L 
Sbjct: 4058 TTGTTQHSTPALSSPHPSSRTTESPPSPGTTTP---GHTTATSRTTATATPSKTRTSTL- 4113

Query: 355  QERNMLPSTPLKPPVPNLHEDIQKLNCNPE 384
                 LPS+P   P+      +    C P+
Sbjct: 4114 -----LPSSPTSAPITT----VVTTGCEPQ 4134



 Score = 38.9 bits (89), Expect = 0.027
 Identities = 69/335 (20%), Positives = 109/335 (32%), Gaps = 58/335 (17%)

Query: 64   AKTLNPVSGQSNYGGSQGSGQTLNRPPVASNPVTPSLHSGPAPRMPLPASQNPATTPMPS 123
            A T       +    + G+  T   P   +   T +  S P   +  P   +  TTP   
Sbjct: 2030 ATTTGATGSVATPSSTPGTAHTTKVPTTTTTGFTATPSSSPGTALTPPVWISTTTTPTTR 2089

Query: 124  SSFLPEANLPPPLNWQYNYPSTASQTNHCPRASSQPTVSGNTSLTTNHQYVSSGYPSLQN 183
             S +  +++P                          T    T LTT    V++G  +  +
Sbjct: 2090 GSTVTPSSIP-------------------------GTTHTATVLTTTTTTVATGSMATPS 2124

Query: 184  SFIKSGPSVPPLVNPPLPTTFQPGAPHGPPPAGGPPPV------RALTPLTSSYRDVP-Q 236
            S  ++    PP +     T    G+   P    G  P+       A TP  +S    P  
Sbjct: 2125 SSTQTS-GTPPSLTTTATTITATGSTTNPSSTPGTTPIPPVLTTTATTPAATSNTVTPSS 2183

Query: 237  PLFNSAVNQEGITSNTNNGSMVVHSSYDEIE------GGGLLATPQLTNKNPKMSRSVGY 290
             L  +       T  T +G  +  SS   +         G+L T  +T  +   S ++  
Sbjct: 2184 ALGTTHTPPVPNTMATTHGRSLPPSSPHTVRTAWTSATSGILGTTHITEPSTVTSHTL-- 2241

Query: 291  SYPSLPPGYQNTTPPGATGVPPSSLNYPSGPQAFTQTPLGANHLT-TSMSGLSLQPEGLR 349
               +   G    + P  +   PSS    S P   T TP    H T TS +  +  P   R
Sbjct: 2242 ---AATTGTTQHSTPALSSPHPSSRTTESPPSPGTTTP---GHTTATSRTTATATPSKTR 2295

Query: 350  VVNLLQERNMLPSTPLKPPVPNLHEDIQKLNCNPE 384
               L      LPS+P   P+      +  + C P+
Sbjct: 2296 TSTL------LPSSPTSAPITT----VVTMGCEPQ 2320



 Score = 36.2 bits (82), Expect = 0.17
 Identities = 65/317 (20%), Positives = 103/317 (32%), Gaps = 56/317 (17%)

Query: 81   GSGQTLNRPPVASNPVTPSLHSGPAPRMPLPASQNPATTPMPSSSFLPEANLPPPLNWQY 140
            G+  T   P   +   T +  S P   +  P   +  TTP    S +  +++P       
Sbjct: 3304 GTAHTTKVPTTTTTGFTATPSSSPGTALTPPVWISTTTTPTTRGSTVTPSSIP------- 3356

Query: 141  NYPSTASQTNHCPRASSQPTVSGNTSLTTNHQYVSSGYPSLQNSFIKSGPSVPPLVNPPL 200
                               T    T LTT    V++G  +  +S  ++    PP +    
Sbjct: 3357 ------------------GTTHTATVLTTTTTTVATGSMATPSSSTQTS-GTPPSLTTTA 3397

Query: 201  PTTFQPGAPHGPPPAGGPPPV------RALTPLTSSYRDVP-QPLFNSAVNQEGITSNTN 253
             T    G+   P    G  P+       A TP  +S    P   L  +       T+ T 
Sbjct: 3398 TTITATGSTTNPSSTPGTTPIPPVLTTTATTPAATSSTVTPSSALGTTHTPPVPNTTATT 3457

Query: 254  NGSMVVHSSYDEIE------GGGLLATPQLTNKNPKMSRSVGYSYPSLPPGYQNTTPPGA 307
            +G  +  SS   +         G+L T  +T  +   S +     P+        + P  
Sbjct: 3458 HGRSLPPSSPHTVRTAWTSATSGILGTTHITEPSTVTSHT-----PAATTSTTQHSTPAL 3512

Query: 308  TGVPPSSLNYPSGPQAFTQTPLGANHLTTSMSGLSLQPEGLRVVNLLQERNMLPSTPLKP 367
            +   PSS    S P   T TP   +   TS +  +  P   R   L      LPS+P   
Sbjct: 3513 SSPHPSSRTTESPPSPGTTTP--GHTRGTSRTTATATPSKTRTSTL------LPSSPTSA 3564

Query: 368  PVPNLHEDIQKLNCNPE 384
            P+      +    C P+
Sbjct: 3565 PITT----VVTTGCEPQ 3577



 Score = 35.0 bits (79), Expect = 0.39
 Identities = 51/227 (22%), Positives = 85/227 (37%), Gaps = 12/227 (5%)

Query: 118  TTPMPSSSFLPEANLPPPLNWQYNYPSTASQTNHCPRASSQPTVSGNTSLTTNHQYVSSG 177
            +TP  SS+  P +   P   W    P+T + T     +++ PT +  T+        ++ 
Sbjct: 1890 STPATSSTATPSST--PGTTWILTKPTTTATTTASTGSTATPTSTLRTAPPPKVLTTTAT 1947

Query: 178  YPSLQNSFIKSGPSVPPLVNPPLPTTFQPGAPHGPPPAGGPPPVRALTPLTSSYRDVPQP 237
             P++ +S  K+ PS  P     LP   +  A      +  P P  +L    +       P
Sbjct: 1948 TPTVTSS--KATPSSSPGTATALP-ALRSTATTPTATSVTPIPSSSLGTTWTRLSQTTTP 2004

Query: 238  LFNSAVNQEGITSNTNNGSMVVHSSYDEIEGGGLLATPQL------TNKNPKMSRSVGYS 291
                +      T  T + S V+ ++       G +ATP        T K P  + +   +
Sbjct: 2005 TATMSTATPSSTPETAHTSTVLTATATTTGATGSVATPSSTPGTAHTTKVPTTTTTGFTA 2064

Query: 292  YPSLPPGYQNTTPPG-ATGVPPSSLNYPSGPQAFTQTPLGANHLTTS 337
             PS  PG   T P   +T   P++      P +   T   A  LTT+
Sbjct: 2065 TPSSSPGTALTPPVWISTTTTPTTRGSTVTPSSIPGTTHTATVLTTT 2111



 Score = 30.8 bits (68), Expect = 7.3
 Identities = 68/324 (20%), Positives = 107/324 (33%), Gaps = 27/324 (8%)

Query: 118  TTPMPSSSFLPEANLPPPLNWQYNYPSTASQTNHCPRASSQPTVSGNTSLTTNHQYVSSG 177
            TT    S+  P +   P   W    PST + T   P  S+    S   +  T H   ++ 
Sbjct: 4433 TTASTGSTATPSST--PGTTWILTEPSTTA-TVTVPTGSTATASSTQATAGTPHVSTTAT 4489

Query: 178  YPSLQNSFIKSGPSVPPLVNPPLPTTFQPGA-PHGPPPAGGPPPVRALTPLTSSYRDVPQ 236
             P++ +S  K+ PS  P     LP        P        P      T    S    P 
Sbjct: 4490 TPTVTSS--KATPSSSPGTATALPALRSTATTPTATSFTAIPSSSLGTTWTRLSQTTTPT 4547

Query: 237  PLFNSAVNQEGITSNTNNGSMVVHSSYDEIEGGGLLATPQLTN---KNPKMSRSVGYSYP 293
               ++A      T  T + S V+ ++       G +ATP  T       K+  +    + 
Sbjct: 4548 ATMSTATPSS--TPETVHTSTVLTATATTTGATGSVATPSSTPGTAHTTKVPTTTTTGFT 4605

Query: 294  SLPPGYQNTTPPGATGVPPSSLNYPSGPQAFTQTPLGANHLTTSMSGLSLQPEGLRVVNL 353
            + P     ++ PG    PP  ++  + P   T T  G+    +S+ G +     L     
Sbjct: 4606 ATP-----SSSPGTALTPPVWISTTTTPTTTTPTTSGSTVTPSSIPGTTHTARVLTTTTT 4660

Query: 354  LQERNMLPSTPLKPPVPNLHEDIQKLNCNPELFRCTLTSIPQTQALLNKAKLPLGLLLHP 413
                  + +TP             + +  P     T T+I  T +  N +  P    + P
Sbjct: 4661 TVATGSM-ATP---------SSSTQTSGTPPSLTTTATTITATGSTTNPSSTPGTTPITP 4710

Query: 414  -FKDLVQLPVVTSSTIVRCRSCRT 436
                    P  TSS      S RT
Sbjct: 4711 VLTSTATTPAATSSKATSSSSPRT 4734


>gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo
           sapiens]
          Length = 5537

 Score = 51.6 bits (122), Expect = 4e-06
 Identities = 42/155 (27%), Positives = 63/155 (40%), Gaps = 9/155 (5%)

Query: 90  PVASNPVTPSLHSGPAPRMPLPASQNPATTPMPSSSFLPEANLPPPLNWQYNYPSTASQT 149
           P+  +P++P   S P+P +  P S  P  +P+ S  F      PPP     + P  AS+ 
Sbjct: 514 PLEESPLSPPEESPPSPALETPLSPPPEASPL-SPPFEESPLSPPPEELPTSPPPEASRL 572

Query: 150 NHCPRASSQPTVSGNTSLTTNHQYVSSGYPSLQNSFIKSGPSVPPLVNPPLPTTFQP--- 206
           +  P  S        + ++   +  S  +P  + S +   P   PL  PP  +   P   
Sbjct: 573 SPPPEESPMSPPPEESPMSPPPE-ASRLFPPFEESPLSPPPEESPLSPPPEASRLSPPPE 631

Query: 207 GAPHGPPPAGGP----PPVRALTPLTSSYRDVPQP 237
            +P  PPP   P    P V  L+PL    R  P P
Sbjct: 632 DSPMSPPPEESPMSPPPEVSRLSPLPVVSRLSPPP 666



 Score = 38.5 bits (88), Expect = 0.035
 Identities = 46/163 (28%), Positives = 60/163 (36%), Gaps = 35/163 (21%)

Query: 2    SQPGIPASGGAPA--SLQAQNGAALASG------SPYTNGPVQNALLSSQESVSQGYNFQ 53
            S  G+P  G  P    L+AQ    LA        SP     +Q  L+  Q   SQ    Q
Sbjct: 4181 SGQGLPGVGIMPTVGQLRAQLQGVLAKNPQLRHLSPQQQQQLQALLMQRQLQQSQAVR-Q 4239

Query: 54   LPGSYPHPIPAKTLNPVSG----QSNYGG----------SQGSGQTLNRPP--------V 91
             P   P+  P    +P+ G    Q   GG            G+G     PP        +
Sbjct: 4240 TP---PYQEPGTQTSPLQGLLGCQPQLGGFPGPQTGPLQELGAGPRPQGPPRLPAPPGAL 4296

Query: 92   ASNPVTPSLHSGPAPRMPLPASQNPATTPMPSSSFLPEANLPP 134
            ++ PV   +H  P P  P    + P+  P PSS    EA LPP
Sbjct: 4297 STGPVLGPVHPTPPPSSP-QEPKRPSQLPSPSSQLPTEAQLPP 4338



 Score = 35.0 bits (79), Expect = 0.39
 Identities = 38/140 (27%), Positives = 49/140 (35%), Gaps = 20/140 (14%)

Query: 89  PPVASNPVTPSLHSGPAPRMPLPASQNPATTPMPSSSFLPEANLPPPLNWQYNYPSTASQ 148
           P ++  P  P L   P      P S+ P  +P P  S L      PPL+ +   P    +
Sbjct: 813 PHLSPVPEEPCLSPQPEESHLSPQSEEPCLSPRPEESHLSPELEKPPLSPRPEKP--PEE 870

Query: 149 TNHCPRASSQPTV--SGNTSLTTNHQYVSSGYPSLQNSFIKSGPSVPPLVNPPLPTTFQP 206
              CP     P     G  SL+        G P+L      S P  PPL   P      P
Sbjct: 871 PGQCPAPEELPLFPPPGEPSLSP-----LLGEPAL------SEPGEPPLSPLPEELPLSP 919

Query: 207 G-----APHGPPPAGGPPPV 221
                 +P   PP   PPP+
Sbjct: 920 SGEPSLSPQLMPPDPLPPPL 939



 Score = 32.7 bits (73), Expect = 1.9
 Identities = 39/157 (24%), Positives = 58/157 (36%), Gaps = 24/157 (15%)

Query: 89  PPVASNPVTPSLHSGPAPRMPLPASQNPATTPMPSSSFLPEA-----------NLPPPLN 137
           PP   +P++P     P    P  +  +P    +P+S  LPEA             PPP  
Sbjct: 442 PPPEESPLSPPPEESPTSPPPEASRLSPPPEELPASP-LPEALHLSRPLEESPLSPPPEE 500

Query: 138 WQYNYPSTAS------QTNHCPRASSQPTVSGNTSLTTNHQYVSSGYPSLQNSFIKSGPS 191
              + P  +S      ++   P   S P+ +  T L+   +  S   P  + S +   P 
Sbjct: 501 SPLSPPPESSPFSPLEESPLSPPEESPPSPALETPLSPPPE-ASPLSPPFEESPLSPPPE 559

Query: 192 VPPLVNPPLPTTFQP---GAPHGPPPAGGP--PPVRA 223
             P   PP  +   P    +P  PPP   P  PP  A
Sbjct: 560 ELPTSPPPEASRLSPPPEESPMSPPPEESPMSPPPEA 596



 Score = 32.7 bits (73), Expect = 1.9
 Identities = 69/317 (21%), Positives = 102/317 (32%), Gaps = 49/317 (15%)

Query: 90   PVASNPVTPSLHSGPAPRMPLPASQNPATTPMPSSSFLPEANLPPPLN------------ 137
            P  S P  P L   P   +PL  S  P+ +P      +P   LPPPL+            
Sbjct: 898  PALSEPGEPPLSPLPE-ELPLSPSGEPSLSPQ----LMPPDPLPPPLSPIITAAAPPALS 952

Query: 138  --WQYNYPSTASQTNHCPRASSQPTVSGNTSLTTNHQYVSSGYPSLQNSFIKSGPSVP-- 193
               +  YP  A   +      + P +   T ++   +   +    +    +   P  P  
Sbjct: 953  PLGELEYPFGAKGDSDPESPLAAPIL--ETPISPPPEANCTDPEPVPPMILPPSPGSPVG 1010

Query: 194  ---PLVNPPLPTTFQPGAPHGPPPAGGPPPVRALTPLTSSYRDVPQPLFNSAVNQEGITS 250
               P++  PLP    P   H   P   PP   +   L  S   VP PL  S + +    S
Sbjct: 1011 PASPILMEPLPPQCSPLLQHSLVPQNSPPSQCSPPALPLS---VPSPL--SPIGKVVGVS 1065

Query: 251  NTNNGSMVVHSSYDEIEGGGLLATPQLTNKNPKMSRSVGYSYPSLPPGYQNTTPPGATGV 310
            +      +      E E   L   P  T+  P     +    PS  P   + +  G    
Sbjct: 1066 DEAELHEMETEKVSEPECPAL--EPSATSPLPSPMGDLSCPAPSPAPALDDFSGLGEDTA 1123

Query: 311  PPSSLNYPSGPQAFTQTPLGANHLTTSMSGLSLQPEGLRVVNLLQ--------------- 355
            P   ++ P       QTP G+       S + L PE L  V  ++               
Sbjct: 1124 PLDGIDAPGSQPEPGQTP-GSLASELKGSPVLLDPEELAPVTPMEVYPECKQTAGQGSPC 1182

Query: 356  ERNMLPSTPLKPPVPNL 372
            E    P  P+ P  P L
Sbjct: 1183 EEQEEPRAPVAPTPPTL 1199



 Score = 30.4 bits (67), Expect = 9.6
 Identities = 20/52 (38%), Positives = 24/52 (46%), Gaps = 4/52 (7%)

Query: 69   PVSGQSNYGGSQGSGQTLNRPPVASNPVTPSLHSGPAPRMPLPASQNPATTP 120
            PV+GQS   G+ GSG     P   S  +T +  S P    P P S  P T P
Sbjct: 4584 PVNGQSQLRGAFGSGALPTGPDYYSQLLTKNNLSNP----PTPPSSLPPTPP 4631


>gi|31543535 R3H domain containing 1 [Homo sapiens]
          Length = 1099

 Score = 51.6 bits (122), Expect = 4e-06
 Identities = 73/307 (23%), Positives = 106/307 (34%), Gaps = 59/307 (19%)

Query: 26  SGSPYTNGPVQNALLSSQESVSQGYNFQLPGSYPHPIPAKTLNPVSG----QSNYGGSQG 81
           +G P+ N P  + ++ +     Q    Q+PG    P+PA    P +     Q N G SQ 
Sbjct: 491 TGQPFIN-PDGSPVVYNPPMTQQPVRSQVPGPPQPPLPAPPQQPAANHIFSQDNLG-SQF 548

Query: 82  SGQTLNRPPVA--SNPVTPSLHSGPAPRMPLPASQNPATTPMPSSSFLPEANLPPPLNWQ 139
           S  +L R P A  S+P      S    + P  +       P P     P    PPP    
Sbjct: 549 SHMSLARQPSADGSDPHAAMFQSTVVLQSPQQSGYIMTAAPPPHPPPPPPPPPPPP---- 604

Query: 140 YNYPSTASQTNHCPRASSQPTVSGNTSLTTNHQYVSSGYPSLQNSFIKSGPSVPPLVNPP 199
                        P    QP  +          Y +SG+P  Q    + G    P  +P 
Sbjct: 605 -------------PLPPGQPVPTAG--------YPASGHPVSQPVLQQQGYIQQP--SPQ 641

Query: 200 LPTTF-QPGAPHGPPPAGGPPPVRALTPLTSSYRDVPQPLFNSAVNQEGITSNTNNGSMV 258
           +P  +  PG  H   P                YR VP   +NS +NQ         G  V
Sbjct: 642 MPACYCAPGHYHSSQP---------------QYRPVPSVHYNSHLNQPLPQPAQQTGYQV 686

Query: 259 VHSSYDEIEGGGLLATPQLTNKNPKMSRSVGYS-------YPSLPPGYQNTTPPGATGVP 311
           + +     +G   +  PQ  +       S+G         Y S+P  YQ + P G+ G+P
Sbjct: 687 IPNQQQNYQGIVGVQQPQSQSLVSGQPNSIGNQIQGVVIPYTSVPT-YQVSLPQGSQGIP 745

Query: 312 PSSLNYP 318
             +   P
Sbjct: 746 HQTYQQP 752



 Score = 38.9 bits (89), Expect = 0.027
 Identities = 85/376 (22%), Positives = 133/376 (35%), Gaps = 55/376 (14%)

Query: 8   ASGGAPASLQA--QNGAALASGSPYTNGPVQNALLSSQESVSQGYNFQLPGSYPHPIPAK 65
           ASG +  S Q+  +N    +   P+++    ++L + + +V++  +F         I   
Sbjct: 336 ASGRSTNSHQSSTENELKYSEPRPWSSTDSDSSLRNLKPAVTKASSFS-------GISVL 388

Query: 66  TLNPVSGQSNYGGSQGSGQTLNRPPVASNPVTPSLHSGPAPRMPLPASQNPATTPMPSSS 125
           T    SG S   G      + +   V S+  + S    P P   L  S + A    P+ S
Sbjct: 389 TRGDSSGSSKSIGRLSKTGSESSGSVGSSTGSLSHIQQPLPGTALSQSSHGAPVVYPTVS 448

Query: 126 FLPEANLPPPLNWQYNYPSTASQTNHCPRASSQPTVSGNTSLTTNHQYVSSGYPSLQNSF 185
                +    LN Q   PST+        A   P      S+  N Q   +G P     F
Sbjct: 449 THSSLSFDGGLNGQVASPSTSFFLLPLEAAGIPPG-----SILINPQ---TGQP-----F 495

Query: 186 IKSGPSVPPLVNPPL---PTTFQ-PGAPHGPPPAGGPPPVRALTPLTSSYRDVPQPLFNS 241
           I    S P + NPP+   P   Q PG P  P PA   PP               QP  N 
Sbjct: 496 INPDGS-PVVYNPPMTQQPVRSQVPGPPQPPLPA---PP--------------QQPAANH 537

Query: 242 AVNQEGITSNTNNGSMVVHSSYDEIEGGGLLATPQLTNKNPKMSRSVGYSYPSLPPGYQN 301
             +Q+ + S  ++ S+    S D  +    +    +  ++P+ S  +  + P   P    
Sbjct: 538 IFSQDNLGSQFSHMSLARQPSADGSDPHAAMFQSTVVLQSPQQSGYIMTAAPPPHPPPPP 597

Query: 302 TTPPGATGVPPS----SLNYPSGPQAFTQTPLGANHLTTSMSGLSLQPEGLRVVNLLQER 357
             PP    +PP     +  YP+     +Q  L          G   QP            
Sbjct: 598 PPPPPPPPLPPGQPVPTAGYPASGHPVSQPVL-------QQQGYIQQPSPQMPACYCAPG 650

Query: 358 NMLPSTPLKPPVPNLH 373
           +   S P   PVP++H
Sbjct: 651 HYHSSQPQYRPVPSVH 666


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.316    0.133    0.392 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 47,546,129
Number of Sequences: 37866
Number of extensions: 2662689
Number of successful extensions: 19573
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 90
Number of HSP's successfully gapped in prelim test: 859
Number of HSP's that attempted gapping in prelim test: 13239
Number of HSP's gapped (non-prelim): 4612
length of query: 1093
length of database: 18,247,518
effective HSP length: 113
effective length of query: 980
effective length of database: 13,968,660
effective search space: 13689286800
effective search space used: 13689286800
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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