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Search of human proteins with 116089337
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|116089337 IQ motif containing GTPase activating protein 2
[Homo sapiens]
(1575 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|116089337 IQ motif containing GTPase activating protein 2 [Ho... 3086 0.0
gi|4506787 IQ motif containing GTPase activating protein 1 [Homo... 1813 0.0
gi|39753961 IQ motif containing GTPase activating protein 3 [Hom... 1232 0.0
gi|4557793 neurofibromin isoform 2 [Homo sapiens] 76 2e-13
gi|109826564 neurofibromin isoform 1 [Homo sapiens] 67 1e-10
gi|4758808 RAS protein activator like 2 isoform 1 [Homo sapiens] 58 6e-08
gi|194248068 synaptic Ras GTPase activating protein 1 [Homo sapi... 55 5e-07
gi|4506431 RAS p21 protein activator 1 isoform 1 [Homo sapiens] 55 7e-07
gi|12545406 RAS p21 protein activator 1 isoform 2 [Homo sapiens] 55 7e-07
gi|41281683 disabled homolog 2 interacting protein isoform 2 [Ho... 54 1e-06
gi|94967023 disabled homolog 2 interacting protein isoform 1 [Ho... 54 1e-06
gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens] 54 2e-06
gi|51093832 GTPase activating protein and VPS9 domains 1 [Homo s... 50 2e-05
gi|226958575 RAS protein activator like 2 isoform 2 [Homo sapiens] 49 3e-05
gi|4759026 RAS protein activator like 1 [Homo sapiens] 49 3e-05
gi|217272804 hyaluronan-mediated motility receptor isoform d [Ho... 48 7e-05
gi|217272802 hyaluronan-mediated motility receptor isoform a [Ho... 48 7e-05
gi|217416398 hyaluronan-mediated motility receptor isoform c [Ho... 48 7e-05
gi|217416394 hyaluronan-mediated motility receptor isoform b [Ho... 48 7e-05
gi|205277396 dynactin 1 isoform 4 [Homo sapiens] 47 1e-04
gi|205277392 dynactin 1 isoform 3 [Homo sapiens] 47 1e-04
gi|13259508 dynactin 1 isoform 2 [Homo sapiens] 47 1e-04
gi|13259510 dynactin 1 isoform 1 [Homo sapiens] 47 1e-04
gi|126116596 asp (abnormal spindle)-like, microcephaly associate... 46 3e-04
gi|51972208 leucine, glutamate and lysine rich 1 [Homo sapiens] 42 0.006
gi|38176300 nestin [Homo sapiens] 41 0.010
gi|150010558 myosin, heavy polypeptide 15 [Homo sapiens] 41 0.010
gi|130502162 RAS protein activator like 3 [Homo sapiens] 41 0.010
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens] 40 0.014
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 40 0.018
>gi|116089337 IQ motif containing GTPase activating protein 2 [Homo
sapiens]
Length = 1575
Score = 3086 bits (8002), Expect = 0.0
Identities = 1575/1575 (100%), Positives = 1575/1575 (100%)
Query: 1 MPHEELPSLQRPRYGSIVDDERLSAEEMDERRRQNIAYEYLCHLEEAKRWMEVCLVEELP 60
MPHEELPSLQRPRYGSIVDDERLSAEEMDERRRQNIAYEYLCHLEEAKRWMEVCLVEELP
Sbjct: 1 MPHEELPSLQRPRYGSIVDDERLSAEEMDERRRQNIAYEYLCHLEEAKRWMEVCLVEELP 60
Query: 61 PTTELEEGLRNGVYLAKLAKFFAPKMVSEKKIYDVEQTRYKKSGLHFRHTDNTVQWLRAM 120
PTTELEEGLRNGVYLAKLAKFFAPKMVSEKKIYDVEQTRYKKSGLHFRHTDNTVQWLRAM
Sbjct: 61 PTTELEEGLRNGVYLAKLAKFFAPKMVSEKKIYDVEQTRYKKSGLHFRHTDNTVQWLRAM 120
Query: 121 ESIGLPKIFYPETTDVYDRKNIPRMIYCIHALSLYLFKLGIAPQIQDLLGKVDFTEEEIS 180
ESIGLPKIFYPETTDVYDRKNIPRMIYCIHALSLYLFKLGIAPQIQDLLGKVDFTEEEIS
Sbjct: 121 ESIGLPKIFYPETTDVYDRKNIPRMIYCIHALSLYLFKLGIAPQIQDLLGKVDFTEEEIS 180
Query: 181 NMRKELEKYGIQMPSFSKIGGILANELSVDEAALHAAVIAINEAVEKGIAEQTVVTLRNP 240
NMRKELEKYGIQMPSFSKIGGILANELSVDEAALHAAVIAINEAVEKGIAEQTVVTLRNP
Sbjct: 181 NMRKELEKYGIQMPSFSKIGGILANELSVDEAALHAAVIAINEAVEKGIAEQTVVTLRNP 240
Query: 241 NAVLTLVDDNLAPEYQKELWDAKKKKEENARLKNSCISEEERDAYEELLTQAEIQGNINK 300
NAVLTLVDDNLAPEYQKELWDAKKKKEENARLKNSCISEEERDAYEELLTQAEIQGNINK
Sbjct: 241 NAVLTLVDDNLAPEYQKELWDAKKKKEENARLKNSCISEEERDAYEELLTQAEIQGNINK 300
Query: 301 VNRQAAVDHINAVIPEGDPENTLLALKKPEAQLPAVYPFAAAMYQNELFNLQKQNTMNYL 360
VNRQAAVDHINAVIPEGDPENTLLALKKPEAQLPAVYPFAAAMYQNELFNLQKQNTMNYL
Sbjct: 301 VNRQAAVDHINAVIPEGDPENTLLALKKPEAQLPAVYPFAAAMYQNELFNLQKQNTMNYL 360
Query: 361 AHEELLIAVEMLSAVALLNQALESNDLVSVQNQLRSPAIGLNNLDKAYVERYANTLLSVK 420
AHEELLIAVEMLSAVALLNQALESNDLVSVQNQLRSPAIGLNNLDKAYVERYANTLLSVK
Sbjct: 361 AHEELLIAVEMLSAVALLNQALESNDLVSVQNQLRSPAIGLNNLDKAYVERYANTLLSVK 420
Query: 421 LEVLSQGQDNLSWNEIQNCIDMVNAQIQEENDRVVAVGYINEAIDEGNPLRTLETLLLPT 480
LEVLSQGQDNLSWNEIQNCIDMVNAQIQEENDRVVAVGYINEAIDEGNPLRTLETLLLPT
Sbjct: 421 LEVLSQGQDNLSWNEIQNCIDMVNAQIQEENDRVVAVGYINEAIDEGNPLRTLETLLLPT 480
Query: 481 ANISDVDPAHAQHYQDVLYHAKSQKLGDSESVSKVLWLDEIQQAVDDANVDEDRAKQWVT 540
ANISDVDPAHAQHYQDVLYHAKSQKLGDSESVSKVLWLDEIQQAVDDANVDEDRAKQWVT
Sbjct: 481 ANISDVDPAHAQHYQDVLYHAKSQKLGDSESVSKVLWLDEIQQAVDDANVDEDRAKQWVT 540
Query: 541 LVVDVNQCLEGKKSSDILSVLKSSTSNANDIIPECADKYYDALVKAKELKSERVSSDGSW 600
LVVDVNQCLEGKKSSDILSVLKSSTSNANDIIPECADKYYDALVKAKELKSERVSSDGSW
Sbjct: 541 LVVDVNQCLEGKKSSDILSVLKSSTSNANDIIPECADKYYDALVKAKELKSERVSSDGSW 600
Query: 601 LKLNLHKKYDYYYNTDSKESSWVTPESCLYKESWLTGKEIEDIIEEVTVGYIRENIWSAS 660
LKLNLHKKYDYYYNTDSKESSWVTPESCLYKESWLTGKEIEDIIEEVTVGYIRENIWSAS
Sbjct: 601 LKLNLHKKYDYYYNTDSKESSWVTPESCLYKESWLTGKEIEDIIEEVTVGYIRENIWSAS 660
Query: 661 EELLLRFQATSSGPILREEFEARKSFLHEQEENVVKIQAFWKGYKQRKEYMHRRQTFIDN 720
EELLLRFQATSSGPILREEFEARKSFLHEQEENVVKIQAFWKGYKQRKEYMHRRQTFIDN
Sbjct: 661 EELLLRFQATSSGPILREEFEARKSFLHEQEENVVKIQAFWKGYKQRKEYMHRRQTFIDN 720
Query: 721 TDSIVKIQSWFRMATARKSYLSRLQYFRDHNNEIVKIQSLLRANKARDDYKTLVGSENPP 780
TDSIVKIQSWFRMATARKSYLSRLQYFRDHNNEIVKIQSLLRANKARDDYKTLVGSENPP
Sbjct: 721 TDSIVKIQSWFRMATARKSYLSRLQYFRDHNNEIVKIQSLLRANKARDDYKTLVGSENPP 780
Query: 781 LTVIRKFVYLLDQSDLDFQEELEVARLREEVVTKIRANQQLEKDLNLMDIKIGLLVKNRI 840
LTVIRKFVYLLDQSDLDFQEELEVARLREEVVTKIRANQQLEKDLNLMDIKIGLLVKNRI
Sbjct: 781 LTVIRKFVYLLDQSDLDFQEELEVARLREEVVTKIRANQQLEKDLNLMDIKIGLLVKNRI 840
Query: 841 TLEDVISHSKKLNKKKGGEMEILNNTDNQGIKSLSKERRKTLETYQQLFYLLQTNPLYLA 900
TLEDVISHSKKLNKKKGGEMEILNNTDNQGIKSLSKERRKTLETYQQLFYLLQTNPLYLA
Sbjct: 841 TLEDVISHSKKLNKKKGGEMEILNNTDNQGIKSLSKERRKTLETYQQLFYLLQTNPLYLA 900
Query: 901 KLIFQMPQNKSTKFMDTVIFTLYNYASNQREEYLLLKLFKTALEEEIKSKVDQVQDIVTG 960
KLIFQMPQNKSTKFMDTVIFTLYNYASNQREEYLLLKLFKTALEEEIKSKVDQVQDIVTG
Sbjct: 901 KLIFQMPQNKSTKFMDTVIFTLYNYASNQREEYLLLKLFKTALEEEIKSKVDQVQDIVTG 960
Query: 961 NPTVIKMVVSFNRGARGQNTLRQLLAPVVKEIIDDKSLIINTNPVEVYKAWVNQLETQTG 1020
NPTVIKMVVSFNRGARGQNTLRQLLAPVVKEIIDDKSLIINTNPVEVYKAWVNQLETQTG
Sbjct: 961 NPTVIKMVVSFNRGARGQNTLRQLLAPVVKEIIDDKSLIINTNPVEVYKAWVNQLETQTG 1020
Query: 1021 EASKLPYDVTTEQALTYPEVKNKLEASIENLRRVTDKVLNSIISSLDLLPYGLRYIAKVL 1080
EASKLPYDVTTEQALTYPEVKNKLEASIENLRRVTDKVLNSIISSLDLLPYGLRYIAKVL
Sbjct: 1021 EASKLPYDVTTEQALTYPEVKNKLEASIENLRRVTDKVLNSIISSLDLLPYGLRYIAKVL 1080
Query: 1081 KNSIHEKFPDATEDELLKIVGNLLYYRYMNPAIVAPDGFDIIDMTAGGQINSDQRRNLGS 1140
KNSIHEKFPDATEDELLKIVGNLLYYRYMNPAIVAPDGFDIIDMTAGGQINSDQRRNLGS
Sbjct: 1081 KNSIHEKFPDATEDELLKIVGNLLYYRYMNPAIVAPDGFDIIDMTAGGQINSDQRRNLGS 1140
Query: 1141 VAKVLQHAASNKLFEGENEHLSSMNNYLSETYQEFRKYFKEACNVPEPEEKFNMDKYTDL 1200
VAKVLQHAASNKLFEGENEHLSSMNNYLSETYQEFRKYFKEACNVPEPEEKFNMDKYTDL
Sbjct: 1141 VAKVLQHAASNKLFEGENEHLSSMNNYLSETYQEFRKYFKEACNVPEPEEKFNMDKYTDL 1200
Query: 1201 VTVSKPVIYISIEEIISTHSLLLEHQDAIAPEKNDLLSELLGSLGEVPTVESFLGEGAVD 1260
VTVSKPVIYISIEEIISTHSLLLEHQDAIAPEKNDLLSELLGSLGEVPTVESFLGEGAVD
Sbjct: 1201 VTVSKPVIYISIEEIISTHSLLLEHQDAIAPEKNDLLSELLGSLGEVPTVESFLGEGAVD 1260
Query: 1261 PNDPNKANTLSQLSKTEISLVLTSKYDIEDGEAIDSRSLMIKTKKLIIDVIRNQPGNTLT 1320
PNDPNKANTLSQLSKTEISLVLTSKYDIEDGEAIDSRSLMIKTKKLIIDVIRNQPGNTLT
Sbjct: 1261 PNDPNKANTLSQLSKTEISLVLTSKYDIEDGEAIDSRSLMIKTKKLIIDVIRNQPGNTLT 1320
Query: 1321 EILETPATAQQEVDHATDMVSRAMIDSRTPEEMKHSQSMIEDAQLPLEQKKRKIQRNLRT 1380
EILETPATAQQEVDHATDMVSRAMIDSRTPEEMKHSQSMIEDAQLPLEQKKRKIQRNLRT
Sbjct: 1321 EILETPATAQQEVDHATDMVSRAMIDSRTPEEMKHSQSMIEDAQLPLEQKKRKIQRNLRT 1380
Query: 1381 LEQTGHVSSENKYQDILNEIAKDIRNQRIYRKLRKAELAKLQQTLNALNKKAAFYEEQIN 1440
LEQTGHVSSENKYQDILNEIAKDIRNQRIYRKLRKAELAKLQQTLNALNKKAAFYEEQIN
Sbjct: 1381 LEQTGHVSSENKYQDILNEIAKDIRNQRIYRKLRKAELAKLQQTLNALNKKAAFYEEQIN 1440
Query: 1441 YYDTYIKTCLDNLKRKNTRRSIKLDGKGEPKGAKRAKPVKYTAAKLHEKGVLLDIDDLQT 1500
YYDTYIKTCLDNLKRKNTRRSIKLDGKGEPKGAKRAKPVKYTAAKLHEKGVLLDIDDLQT
Sbjct: 1441 YYDTYIKTCLDNLKRKNTRRSIKLDGKGEPKGAKRAKPVKYTAAKLHEKGVLLDIDDLQT 1500
Query: 1501 NQFKNVTFDIIATEDVGIFDVRSKFLGVEMEKVQLNIQDLLQMQYEGVAVMKMFDKVKVN 1560
NQFKNVTFDIIATEDVGIFDVRSKFLGVEMEKVQLNIQDLLQMQYEGVAVMKMFDKVKVN
Sbjct: 1501 NQFKNVTFDIIATEDVGIFDVRSKFLGVEMEKVQLNIQDLLQMQYEGVAVMKMFDKVKVN 1560
Query: 1561 VNLLIYLLNKKFYGK 1575
VNLLIYLLNKKFYGK
Sbjct: 1561 VNLLIYLLNKKFYGK 1575
>gi|4506787 IQ motif containing GTPase activating protein 1 [Homo
sapiens]
Length = 1657
Score = 1813 bits (4697), Expect = 0.0
Identities = 946/1654 (57%), Positives = 1205/1654 (72%), Gaps = 99/1654 (5%)
Query: 11 RPRYGSIVDDERLSAEEMDERRRQNIAYEYLCHLEEAKRWMEVCLVEELPPTTELEEGLR 70
RP YGS++D+ERL+AEEMDERRRQN+AYEYLCHLEEAKRWME CL E+LPPTTELEEGLR
Sbjct: 14 RPHYGSVLDNERLTAEEMDERRRQNVAYEYLCHLEEAKRWMEACLGEDLPPTTELEEGLR 73
Query: 71 NGVYLAKLAKFFAPKMVSEKKIYDVEQTRYKKSGLHFRHTDNTVQWLRAMESIGLPKIFY 130
NGVYLAKL FF+PK+VS KKIYD EQTRYK +GLHFRHTDN +QWL AM+ IGLPKIFY
Sbjct: 74 NGVYLAKLGNFFSPKVVSLKKIYDREQTRYKATGLHFRHTDNVIQWLNAMDEIGLPKIFY 133
Query: 131 PETTDVYDRKNIPRMIYCIHALSLYLFKLGIAPQIQDLLGKVDFTEEEISNMRKELEKYG 190
PETTD+YDRKN+PR IYCIHALSLYLFKLG+APQIQDL GKVDFTEEEI+NM+ ELEKYG
Sbjct: 134 PETTDIYDRKNMPRCIYCIHALSLYLFKLGLAPQIQDLYGKVDFTEEEINNMKTELEKYG 193
Query: 191 IQMPSFSKIGGILANELSVDEAALHAAVIAINEAVEKGIAEQTVVTLRNPNAVLTLVDDN 250
IQMP+FSKIGGILANELSVDEAALHAAVIAINEA+++ I T L+NPNA+L +++
Sbjct: 194 IQMPAFSKIGGILANELSVDEAALHAAVIAINEAIDRRIPADTFAALKNPNAMLVNLEEP 253
Query: 251 LAPEYQKELWDAKKKKEENARLKNSCISEEERDAYEELLTQAEIQGNINKVNRQAAVDHI 310
LA YQ L+ AK+ K NA+ + SE ERD YEELLTQAEIQGNINKVN +A+ +I
Sbjct: 254 LASTYQDILYQAKQDKMTNAKNRTE-NSERERDVYEELLTQAEIQGNINKVNTFSALANI 312
Query: 311 NAVIPEGDPENTLLALKKPEAQLPAVYPFAAAMYQNELFNLQKQNTM----NYLAHEELL 366
+ + +GD AL+ P L + + Y +L + ++Q + L EEL
Sbjct: 313 DLALEQGDALALFRALQSPALGLRGLQQQNSDWYLKQLLSDKQQKRQSGQTDPLQKEELQ 372
Query: 367 IAVE-----------MLSAVALLNQALESNDLVSVQNQLRSPAIGLNNLDKAYVERYANT 415
V+ L+AVAL+N A++ +L +P L + + Y
Sbjct: 373 SGVDAANSAAQQYQRRLAAVALINAAIQKGVAEKTVLELMNPEAQLPQVYPFAADLYQKE 432
Query: 416 L----------------LSVKLEVLS----------QGQDNLSW---------------- 433
L LSV +E+LS G N W
Sbjct: 433 LATLQRQSPEHNLTHPELSVAVEMLSSVALINRALESGDVNTVWKQLSSSVTGLTNIEEE 492
Query: 434 --------------------------NEIQNCIDMVNAQIQEENDRVVAVGYINEAIDEG 467
N+IQ C+D VN +QEE++R++A+G INEA+DEG
Sbjct: 493 NCQRYLDELMKLKAQAHAENNEFITWNDIQACVDHVNLVVQEEHERILAIGLINEALDEG 552
Query: 468 NPLRTLETLLLPTANISDVDPAHAQHYQDVLYHAKSQKLGDSESVSKVLWLDEIQQAVDD 527
+ +TL+ L +P A + V AQHYQD L AK +K + + S VLWLDEIQ +
Sbjct: 553 DAQKTLQALQIPAAKLEGVLAEVAQHYQDTLIRAKREKAQEIQDESAVLWLDEIQGGIWQ 612
Query: 528 ANVDEDRAKQWVTLVVDVNQCLEGKKSSDILSVLKSSTSNANDIIPECADKYYDALVKAK 587
+N D A+++ + +N+ +E LS L+S +IPEC + Y+ L +AK
Sbjct: 613 SNKDTQEAQKFALGIFAINEAVESGDVGKTLSALRSPDVGLYGVIPECGETYHSDLAEAK 672
Query: 588 ELKSERVSSDGSWLKLNLHKKYDYYYNTDSKESSWVTPESCLYKESWLTGKEIEDIIEEV 647
+ K ++ W+K + Y YY+N +++E W P + + L+ +EI+ I V
Sbjct: 673 KKKLAVGDNNSKWVKHWVKGGYYYYHNLETQEGGWDEPPNFVQNSMQLSREEIQSSISGV 732
Query: 648 TVGYIRENIWSASEELLLRFQATSSGPILREEFEARKSFLHEQEENVVKIQAFWKGYKQR 707
T Y RE +W A+E L+ R QA G ++R+EF +R +FL +Q + IQ+ W+GYKQ+
Sbjct: 733 TAAYNREQLWLANEGLITRLQARCRGYLVRQEFRSRMNFLKKQIPAITCIQSQWRGYKQK 792
Query: 708 KEYMHRRQTFIDNTDSIVKIQSWFRMATARKSYLSRLQYFRDHNNEIVKIQSLLRANKAR 767
K Y R + D +VKIQS RM ARK Y RLQYFRDH N+I+KIQ+ +RANKAR
Sbjct: 793 KAYQDRLAYLRSHKDEVVKIQSLARMHQARKRYRDRLQYFRDHINDIIKIQAFIRANKAR 852
Query: 768 DDYKTLVGSENPPLTVIRKFVYLLDQSDLDFQEELEVARLREEVVTKIRANQQLEKDLNL 827
DDYKTL+ +E+PP+ V+RKFV+LLDQSD DFQEEL++ ++REEV+T IR+NQQLE DLNL
Sbjct: 853 DDYKTLINAEDPPMVVVRKFVHLLDQSDQDFQEELDLMKMREEVITLIRSNQQLENDLNL 912
Query: 828 MDIKIGLLVKNRITLEDVISHSKKLNKKKGGEME--ILNNTDNQGIKSLSKERRKTLETY 885
MDIKIGLLVKN+ITL+DV+SHSKKL KK ++ ++ N G+K+LSKE+R+ LE Y
Sbjct: 913 MDIKIGLLVKNKITLQDVVSHSKKLTKKNKEQLSDMMMINKQKGGLKALSKEKREKLEAY 972
Query: 886 QQLFYLLQTNPLYLAKLIFQMPQNKSTKFMDTVIFTLYNYASNQREEYLLLKLFKTALEE 945
Q LFYLLQTNP YLAKLIFQMPQNKSTKFMD+VIFTLYNYASNQREEYLLL+LFKTAL+E
Sbjct: 973 QHLFYLLQTNPTYLAKLIFQMPQNKSTKFMDSVIFTLYNYASNQREEYLLLRLFKTALQE 1032
Query: 946 EIKSKVDQVQDIVTGNPTVIKMVVSFNRGARGQNTLRQLLAPVVKEIIDDKSLIINTNPV 1005
EIKSKVDQ+Q+IVTGNPTVIKMVVSFNRGARGQN LRQ+LAPVVKEI+DDKSL I T+PV
Sbjct: 1033 EIKSKVDQIQEIVTGNPTVIKMVVSFNRGARGQNALRQILAPVVKEIMDDKSLNIKTDPV 1092
Query: 1006 EVYKAWVNQLETQTGEASKLPYDVTTEQALTYPEVKNKLEASIENLRRVTDKVLNSIISS 1065
++YK+WVNQ+E+QTGEASKLPYDVT EQAL + EVK +L++SI N+R VTDK L++I+SS
Sbjct: 1093 DIYKSWVNQMESQTGEASKLPYDVTPEQALAHEEVKTRLDSSIRNMRAVTDKFLSAIVSS 1152
Query: 1066 LDLLPYGLRYIAKVLKNSIHEKFPDATEDELLKIVGNLLYYRYMNPAIVAPDGFDIIDMT 1125
+D +PYG+R+IAKVLK+S+HEKFPDA EDELLKI+GNLLYYRYMNPAIVAPD FDIID++
Sbjct: 1153 VDKIPYGMRFIAKVLKDSLHEKFPDAGEDELLKIIGNLLYYRYMNPAIVAPDAFDIIDLS 1212
Query: 1126 AGGQINSDQRRNLGSVAKVLQHAASNKLFEGENEHLSSMNNYLSETYQEFRKYFKEACNV 1185
AGGQ+ +DQRRNLGS+AK+LQHAASNK+F G+N HLS +N YLS++YQ+FR++F+ AC+V
Sbjct: 1213 AGGQLTTDQRRNLGSIAKMLQHAASNKMFLGDNAHLSIINEYLSQSYQKFRRFFQTACDV 1272
Query: 1186 PEPEEKFNMDKYTDLVTVSKPVIYISIEEIISTHSLLLEHQDAIAPEKNDLLSELLGSLG 1245
PE ++KFN+D+Y+DLVT++KPVIYISI EII+TH+LLL+HQDAIAPE ND + ELL LG
Sbjct: 1273 PELQDKFNVDEYSDLVTLTKPVIYISIGEIINTHTLLLDHQDAIAPEHNDPIHELLDDLG 1332
Query: 1246 EVPTVESFLGEGAVDPNDPNKANTLSQLSKTEISLVLTSKYDI--EDGEAIDSRSLMIKT 1303
EVPT+ES +GE + + NDPNK L+KTE+SL LT+K+D+ ++ +D+R++++ T
Sbjct: 1333 EVPTIESLIGESSGNLNDPNK----EALAKTEVSLTLTNKFDVPGDENAEMDARTILLNT 1388
Query: 1304 KKLIIDVIRNQPGNTLTEILETPATAQQEVDHATDMVSRAMIDSRTPEEMKHSQSMIEDA 1363
K+LI+DVIR QPG TLTEILETPAT++QE +H M RA+ D++TP++MK S+S+ ED+
Sbjct: 1389 KRLIVDVIRFQPGETLTEILETPATSEQEAEHQRAMQRRAIRDAKTPDKMKKSKSVKEDS 1448
Query: 1364 QLPLEQKKRKIQRNLRTLEQTGHVSSENKYQDILNEIAKDIRNQRIYRKLRKAELAKLQQ 1423
L L++KK KIQ L+ L + G V +NKYQ+++N+IA+DIRNQR YR+ RKAEL KLQQ
Sbjct: 1449 NLTLQEKKEKIQTGLKKLTELGTVDPKNKYQELINDIARDIRNQRRYRQRRKAELVKLQQ 1508
Query: 1424 TLNALNKKAAFYEEQINYYDTYIKTCLDNLKRKNTRRSIKLDGKGEPKGAKRAKPV--KY 1481
T ALN KA FY EQ++YY +YIKTCLDNL K K+ K K++K + KY
Sbjct: 1509 TYAALNSKATFYGEQVDYYKSYIKTCLDNLASKG-----KVSKKPREMKGKKSKKISLKY 1563
Query: 1482 TAAKLHEKGVLLDIDDLQTNQFKNVTFDIIATEDVGIFDVRSKFLGVEMEKVQLNIQDLL 1541
TAA+LHEKGVLL+I+DLQ NQFKNV F+I TE+VG F+V++KF+GV+ME L+ QDLL
Sbjct: 1564 TAARLHEKGVLLEIEDLQVNQFKNVIFEISPTEEVGDFEVKAKFMGVQMETFMLHYQDLL 1623
Query: 1542 QMQYEGVAVMKMFDKVKVNVNLLIYLLNKKFYGK 1575
Q+QYEGVAVMK+FD+ KVNVNLLI+LLNKKFYGK
Sbjct: 1624 QLQYEGVAVMKLFDRAKVNVNLLIFLLNKKFYGK 1657
>gi|39753961 IQ motif containing GTPase activating protein 3 [Homo
sapiens]
Length = 1631
Score = 1232 bits (3187), Expect = 0.0
Identities = 656/1379 (47%), Positives = 925/1379 (67%), Gaps = 45/1379 (3%)
Query: 208 SVDEAALHAAVIAINEAVEKGIAEQTVVTLRNPNAVLTLVDDNLAPEYQKELWDAKKKKE 267
+++ +H A+ +++A+E+ E + L++P L V + A Y ++L +++K
Sbjct: 287 NINHVNVHGALEVVDDALERQSPEALLKALQDPALALRGVRRDFADWYLEQLNSDREQKA 346
Query: 268 ENARLKNSCISEEERDAYEELLTQAEIQGNINKVNRQA--------AVDHINAVIPEGDP 319
+ L ELL + E+Q + N + AV IN I G
Sbjct: 347 QELGLV-------------ELLEKEEVQAGVAAANTKGDQEQAMLHAVQRINKAIRRGVA 393
Query: 320 ENTLLALKKPEAQLPAVYPFAAAMYQNELFNLQKQNTMNYLAHEELLIAVEMLSAVALLN 379
+T+ L PEAQLP VYP A++MYQ EL LQ+Q L EEL +AVEMLSAV L+N
Sbjct: 394 ADTVKELMCPEAQLPPVYPVASSMYQLELAVLQQQQ--GELGQEELFVAVEMLSAVVLIN 451
Query: 380 QALESNDLVSVQNQLRSPAIGLNNLDKAYVERYANTLLSVKLEVLSQGQDNLSWNEIQNC 439
+ALE+ D + L +PA GL ++ +RY + LL ++ E G+D LSWN++Q
Sbjct: 452 RALEARDASGFWSSLVNPATGLAEVEGENAQRYFDALLKLRQE-RGMGEDFLSWNDLQAT 510
Query: 440 IDMVNAQIQEENDRVVAVGYINEAIDEGNPLRTLETLLLPTANISDVDPAHAQHYQDVLY 499
+ VNAQ QEE DRV+AV INEA+D+G+P +TL LLLP A + DV A Y +L
Sbjct: 511 VSQVNAQTQEETDRVLAVSLINEALDKGSPEKTLSALLLPAAGLDDVSLPVAPRYHLLLV 570
Query: 500 HAKSQKLGDSESVSKVLWLDEIQQAVDDANVDEDRAKQWVTLVVDVNQCLEGKKSSDILS 559
AK QK + VLWL+EI+Q V AN D + A++ V +NQ ++ K++
Sbjct: 571 AAKRQKAQVTGDPGAVLWLEEIRQGVVRANQDTNTAQRMALGVAAINQAIKEGKAAQTER 630
Query: 560 VLKSSTSNANDIIPECADKYYDALVKAKELKSERVSSDGSWLKLNLHKKYDYYYNTDSKE 619
VL++ ++P+CA+ Y AL A K +R + W++ ++ YY++ + +
Sbjct: 631 VLRNPAVALRGVVPDCANGYQRALESAMA-KKQRPADTAFWVQHDMKDGTAYYFHLQTFQ 689
Query: 620 SSWVTPESCLYKESWLTGKEIEDIIEEVTVGYIRENIWSASEELLLRFQATSSGPILREE 679
W P C S LT +EI+ + +VT Y R+ +W A+ +++ QA G ++R++
Sbjct: 690 GIWEQPPGCPLNTSHLTREEIQSAVTKVTAAYDRQQLWKANVGFVIQLQARLRGFLVRQK 749
Query: 680 FEARKSFLHEQEENVVKIQAFWKGYKQRKEYMHRRQTFIDNTDSIVKIQSWFRMATARKS 739
F FL V+KIQA W+GY+QRK Y+ Q F N D+I+KIQ+W RM AR+
Sbjct: 750 FAEHSHFLRTWLPAVIKIQAHWRGYRQRKIYLEWLQYFKANLDAIIKIQAWARMWAARRQ 809
Query: 740 YLSRLQYFRDHNNEIVKIQSLLRANKARDDYKTLVGSENPPLTVIRKFVYLLDQSDLDFQ 799
YL RL YF+ + N IVKIQ+ RA KA+DDY+ LV + +PPL+V+R+F +LL+QS DF
Sbjct: 810 YLRRLHYFQKNVNSIVKIQAFFRARKAQDDYRILVHAPHPPLSVVRRFAHLLNQSQQDFL 869
Query: 800 EELEVARLREEVVTKIRANQQLEKDLNLMDIKIGLLVKNRITLEDVISHSKKLNKKKGGE 859
E E+ +L+EEVV KIR+NQQLE+DLN+MDIKIGLLVKNRITL++V+SH KKL K+ +
Sbjct: 870 AEAELLKLQEEVVRKIRSNQQLEQDLNIMDIKIGLLVKNRITLQEVVSHCKKLTKRNKEQ 929
Query: 860 MEILNNTDNQ-GIKSLSKERRKTLETYQQLFYLLQTNPLYLAKLIFQMPQNKSTKFMDTV 918
+ + D Q G+KSLSKE+R+ LE YQ LFYLLQT P+YLAKLIFQMPQNK+TKFM+ V
Sbjct: 930 LSDMMVLDKQKGLKSLSKEKRQKLEAYQHLFYLLQTQPIYLAKLIFQMPQNKTTKFMEAV 989
Query: 919 IFTLYNYASNQREEYLLLKLFKTALEEEIKSKVDQVQDIVTGNPTVIKMVVSFNRGARGQ 978
IF+LYNYAS++RE YLLL+LFKTAL+EEIKSKV+Q QD+VTGNPTV+++VV F R RGQ
Sbjct: 990 IFSLYNYASSRREAYLLLQLFKTALQEEIKSKVEQPQDVVTGNPTVVRLVVRFYRNGRGQ 1049
Query: 979 NTLRQLLAPVVKEIIDDKSLIINTNPVEVYKAWVNQLETQTGEASKLPYDVTTEQALTYP 1038
+ L+++L V++++++DK L ++T+PV +YK W+NQ E QTG+ S LPYDVT EQAL++P
Sbjct: 1050 SALQEILGKVIQDVLEDKVLSVHTDPVHLYKNWINQTEAQTGQRSHLPYDVTPEQALSHP 1109
Query: 1039 EVKNKLEASIENLRRVTDKVLNSIISSLDLLPYGLRYIAKVLKNSIHEKFPDATEDELLK 1098
EV+ +L+ ++ NL +TDK L +I SS+D +PYG+RY+AKVLK ++ EKFPDAT+ E+ K
Sbjct: 1110 EVQRRLDIALRNLLAMTDKFLLAITSSVDQIPYGMRYVAKVLKATLAEKFPDATDSEVYK 1169
Query: 1099 IVGNLLYYRYMNPAIVAPDGFDIIDMTAGGQINSDQRRNLGSVAKVLQHAASNKLFEGEN 1158
+VGNLLYYR++NPA+VAPD FDI+ M AGG + + QR LG+VA++LQHAA+ K F G++
Sbjct: 1170 VVGNLLYYRFLNPAVVAPDAFDIVAMAAGGALAAPQRHALGAVAQLLQHAAAGKAFSGQS 1229
Query: 1159 EHLSSMNNYLSETYQEFRKYFKEACNVPEPEEKFNMDKYTDLVTVSKPVIYISIEEIIST 1218
+HL +N+YL ET+ +FRK+ AC VPEPEE+F +D+Y+D+V V+KP++YI++ E+++T
Sbjct: 1230 QHLRVLNDYLEETHLKFRKFIHRACQVPEPEERFAVDEYSDMVAVAKPMVYITVGELVNT 1289
Query: 1219 HSLLLEHQDAIAPEKNDLLSELLGSLGEVPTVESFLGEGAVDPNDPNKANTLSQLSKTEI 1278
H LLLEHQD IAP+ D L ELL LGE+PT+ +GE A+ + LSK E+
Sbjct: 1290 HRLLLEHQDCIAPDHQDPLHELLEDLGELPTIPDLIGESIA-------ADGHTDLSKLEV 1342
Query: 1279 SLVLTSKYDIEDGEAIDS--RSLMIKTKKLIIDVIRNQPGNTLTEILETPATAQQEVDHA 1336
SL LT+K++ + +A DS RSL++ TK+L+ D+I+ PG+TL EIL A+ +QE H
Sbjct: 1343 SLTLTNKFEGLEADADDSNTRSLLLSTKQLLADIIQFHPGDTLKEILSLSASREQEAAHK 1402
Query: 1337 TDMVSRAMIDSRTPEEMKHSQSMIEDAQLPLEQKKRKIQRNLRTLEQTGHVSSENKYQDI 1396
M R ++TPE ++ +S+ + LPL +K+R++ RNLR LE G VS+ N YQ +
Sbjct: 1403 QLMSRRQACTAQTPEPLRRHRSLTAHSLLPLAEKQRRVLRNLRRLEALGLVSARNGYQGL 1462
Query: 1397 LNEIAKDIRNQRIYRKLRKAELAKLQQTLNALNKKAAFYEEQINYYDTYIKTCLDNLKRK 1456
++E+AKDIRNQ +R RKAEL KLQ TL L+ K FYEEQ +YY YI+ CLD+L
Sbjct: 1463 VDELAKDIRNQHRHRHRRKAELVKLQATLQGLSTKTTFYEEQGDYYSQYIRACLDHLAPD 1522
Query: 1457 NTRRSIKLDGKGEPKGAKRAKPVKYTAAKLHEKGVLLDIDDLQTNQFKNVTFDIIATEDV 1516
+ K GKG K+ + YTAA+L EKGVL++I+DL + F+NV FDI ++
Sbjct: 1523 S-----KSSGKG-----KKQPSLHYTAAQLLEKGVLVEIEDLPASHFRNVIFDITPGDEA 1572
Query: 1517 GIFDVRSKFLGVEMEKVQLNIQDLLQMQYEGVAVMKMFDKVKVNVNLLIYLLNKKFYGK 1575
G F+V +KFLGV+ME+ QL+ QDLLQ+QYEGVAVMK+F+K KVNVNLLI+LLNKKF K
Sbjct: 1573 GKFEVNAKFLGVDMERFQLHYQDLLQLQYEGVAVMKLFNKAKVNVNLLIFLLNKKFLRK 1631
Score = 433 bits (1113), Expect = e-121
Identities = 259/600 (43%), Positives = 351/600 (58%), Gaps = 41/600 (6%)
Query: 21 ERLSAEEMDERRRQNIAYEYLCHLEEAKRWMEVCLVEELPPTTELEEGLRNGVYLAKLAK 80
ERL+AEEMDE+RRQN+AY+YLC LEEAKRWME CL EELP ELEE LRNGV LAKL
Sbjct: 14 ERLTAEEMDEQRRQNVAYQYLCRLEEAKRWMEACLKEELPSPVELEESLRNGVLLAKLGH 73
Query: 81 FFAPKMVSEKKIYDVEQTRYKKSGLHFRHTDNTVQWLRAMESIGLPKIFYPETTDVYDRK 140
FAP +V KKIYDVEQ RY+ +GLHFRHTDN WL A+ IGLP F+PETTD+YD+K
Sbjct: 74 CFAPSVVPLKKIYDVEQLRYQATGLHFRHTDNINFWLSAIAHIGLPSTFFPETTDIYDKK 133
Query: 141 NIPRMIYCIHALSLYLFKLGIAPQIQDLLGKVDFTEEEISNMRKELEKYGIQMPSFSKIG 200
N+PR++YCIHALSL+LF+LG+APQI DL GKV FT EE+SNM EL KYG+Q+P+FSKIG
Sbjct: 134 NMPRVVYCIHALSLFLFRLGLAPQIHDLYGKVKFTAEELSNMASELAKYGLQLPAFSKIG 193
Query: 201 GILANELSVDEAALHAAVIAINEAVEKGIAEQTVVTLRNPNAVLTLVDDNLAPEYQKELW 260
GILANELSVDEAA+HAAV+AINEAVE+G+ E T+ L+NP+A+L + + LA YQ+ L
Sbjct: 194 GILANELSVDEAAVHAAVLAINEAVERGVVEDTLAALQNPSALLENLREPLAAVYQEMLA 253
Query: 261 DAKKKKEENARLKNSCISEEERDAYEELLTQAEIQGNINKVNRQAAVDHINAVIPEGDPE 320
AK +K NAR + E +D Y+ LTQAEIQGNIN VN A++ ++ + PE
Sbjct: 254 QAKMEKAANARNHD---DRESQDIYDHYLTQAEIQGNINHVNVHGALEVVDDALERQSPE 310
Query: 321 NTLLALKKPEAQLPAVYPFAAAMYQNELFNLQKQNT-----MNYLAHEELLIAV------ 369
L AL+ P L V A Y +L + ++Q + L EE+ V
Sbjct: 311 ALLKALQDPALALRGVRRDFADWYLEQLNSDREQKAQELGLVELLEKEEVQAGVAAANTK 370
Query: 370 -----EMLSAVALLNQALESNDLVSVQNQLRSPAIGLNNLDKAYVERYANTLLSVKLEVL 424
ML AV +N+A+ +L P L V A+++ ++L VL
Sbjct: 371 GDQEQAMLHAVQRINKAIRRGVAADTVKELMCPEAQL-----PPVYPVASSMYQLELAVL 425
Query: 425 SQGQDNLSWNEIQNCIDMVNAQIQEENDRVVAVGYINEAIDEGNPLRTLETLLLPTANIS 484
Q Q L E+ ++M++ AV IN A++ + +L+ P ++
Sbjct: 426 QQQQGELGQEELFVAVEMLS-----------AVVLINRALEARDASGFWSSLVNPATGLA 474
Query: 485 DVDPAHAQHYQDVLYHAKSQKLGDSESVSKVLWLDEIQQAVDDANVDEDRAKQWVTLVVD 544
+V+ +AQ Y D L + ++ + +S W +++Q V N V V
Sbjct: 475 EVEGENAQRYFDALLKLRQERGMGEDFLS---W-NDLQATVSQVNAQTQEETDRVLAVSL 530
Query: 545 VNQCLEGKKSSDILSVLKSSTSNANDIIPECADKYYDALVKAKELKSERVSSDGS--WLK 602
+N+ L+ LS L + +D+ A +Y+ LV AK K++ G+ WL+
Sbjct: 531 INEALDKGSPEKTLSALLLPAAGLDDVSLPVAPRYHLLLVAAKRQKAQVTGDPGAVLWLE 590
Score = 40.4 bits (93), Expect = 0.014
Identities = 26/71 (36%), Positives = 37/71 (52%)
Query: 200 GGILANELSVDEAALHAAVIAINEAVEKGIAEQTVVTLRNPNAVLTLVDDNLAPEYQKEL 259
G + AN+ + + V AIN+A+++G A QT LRNP L V + A YQ+ L
Sbjct: 595 GVVRANQDTNTAQRMALGVAAINQAIKEGKAAQTERVLRNPAVALRGVVPDCANGYQRAL 654
Query: 260 WDAKKKKEENA 270
A KK+ A
Sbjct: 655 ESAMAKKQRPA 665
>gi|4557793 neurofibromin isoform 2 [Homo sapiens]
Length = 2818
Score = 76.3 bits (186), Expect = 2e-13
Identities = 76/313 (24%), Positives = 140/313 (44%), Gaps = 58/313 (18%)
Query: 918 VIFTLYNYASNQREEYLLLKLFKTALEEEIKSKVDQVQDIVTGNPTVIKMVVSFNRGARG 977
V+ TL++ +LL +L +E++ D +Q + GN K +++F G
Sbjct: 1242 VLVTLFD------SRHLLYQLLWNMFSKEVEL-ADSMQTLFRGNSLASK-IMTFCFKVYG 1293
Query: 978 QNTLRQLLAPVVKEIIDDKSLIINTNPVEVYKAWVNQLETQTGEASKLPYDVTTEQALTY 1037
L++LL P+++ +I W + V+ E T
Sbjct: 1294 ATYLQKLLDPLLRIVITSSD-------------WQH---------------VSFEVDPTR 1325
Query: 1038 PEVKNKLEASIENLRRVTDKVLNSIISSLDLLPYGLRYIAKVLKNSIHEKFPDATEDELL 1097
E LE + NL ++T+K ++IISS P LR + L + ++FP + +
Sbjct: 1326 LEPSESLEENQRNLLQMTEKFFHAIISSSSEFPPQLRSVCHCLYQVVSQRFPQNS----I 1381
Query: 1098 KIVGNLLYYRYMNPAIVAPDGFDIIDMTAGGQINSDQRRNLGSVAKVLQHAASNKLFEGE 1157
VG+ ++ R++NPAIV+P I+D +I R L ++K+LQ A++ LF E
Sbjct: 1382 GAVGSAMFLRFINPAIVSPYEAGILDKKPPPRI----ERGLKLMSKILQSIANHVLFTKE 1437
Query: 1158 NEHLSSMNNYLSETYQEFRKYFKE-ACNVPEPEEKFNMDKYTDLVTVSKPVIYISIEEII 1216
EH+ N+++ + R++F + A + P + V+ + +IS ++
Sbjct: 1438 -EHMRPFNDFVKSNFDAARRFFLDIASDCPTSD------------AVNHSLSFISDGNVL 1484
Query: 1217 STHSLLLEHQDAI 1229
+ H LL +Q+ I
Sbjct: 1485 ALHRLLWNNQEKI 1497
>gi|109826564 neurofibromin isoform 1 [Homo sapiens]
Length = 2839
Score = 67.0 bits (162), Expect = 1e-10
Identities = 77/334 (23%), Positives = 142/334 (42%), Gaps = 79/334 (23%)
Query: 918 VIFTLYNYASNQREEYLLLKLFKTALEEEIKSKVDQVQDIVTGNPTVIKMVVSFNRGARG 977
V+ TL++ +LL +L +E++ D +Q + GN K +++F G
Sbjct: 1242 VLVTLFD------SRHLLYQLLWNMFSKEVEL-ADSMQTLFRGNSLASK-IMTFCFKVYG 1293
Query: 978 QNTLRQLLAPVVKEIIDDKSLIINTNPVEVYKAWVNQLETQTGEASKLPYDVTTEQALTY 1037
L++LL P+++ +I W + V+ E T
Sbjct: 1294 ATYLQKLLDPLLRIVITSSD-------------WQH---------------VSFEVDPTR 1325
Query: 1038 PEVKNKLEASIENLRRVTDKVLNSIISSLDLLPYGLRYIAKVL----------------- 1080
E LE + NL ++T+K ++IISS P LR + L
Sbjct: 1326 LEPSESLEENQRNLLQMTEKFFHAIISSSSEFPPQLRSVCHCLYQATCHSLLNKATVKEK 1385
Query: 1081 ----KNSIHEKFPDATEDELLKIVGNLLYYRYMNPAIVAPDGFDIIDMTAGGQINSDQRR 1136
K+ + ++FP + + VG+ ++ R++NPAIV+P I+D +I R
Sbjct: 1386 KENKKSVVSQRFPQNS----IGAVGSAMFLRFINPAIVSPYEAGILDKKPPPRI----ER 1437
Query: 1137 NLGSVAKVLQHAASNKLFEGENEHLSSMNNYLSETYQEFRKYFKE-ACNVPEPEEKFNMD 1195
L ++K+LQ A++ LF E EH+ N+++ + R++F + A + P +
Sbjct: 1438 GLKLMSKILQSIANHVLFTKE-EHMRPFNDFVKSNFDAARRFFLDIASDCPTSD------ 1490
Query: 1196 KYTDLVTVSKPVIYISIEEIISTHSLLLEHQDAI 1229
V+ + +IS +++ H LL +Q+ I
Sbjct: 1491 ------AVNHSLSFISDGNVLALHRLLWNNQEKI 1518
>gi|4758808 RAS protein activator like 2 isoform 1 [Homo sapiens]
Length = 1139
Score = 58.2 bits (139), Expect = 6e-08
Identities = 64/268 (23%), Positives = 111/268 (41%), Gaps = 27/268 (10%)
Query: 1000 INTNPVEVYKAWVNQ--LETQTGEASKLPYDVTTEQALTYPEV--KNKLEASIENLRRVT 1055
I T +E Y V Q L GE K Y+ + E P ++L NL+
Sbjct: 373 IATKSIEEYLKLVGQQYLHDALGEFIKALYE-SDENCEVDPSKCSSSELIDHQSNLKMCC 431
Query: 1056 DKVLNSIISSLDLLPYGLRYIAKVLKNSIHEKFPDATEDELLKIVGNLLYYRYMNPAIVA 1115
+ II+S + P L+ + K + +D +++ L+ R++ PAI++
Sbjct: 432 ELAFCKIINSYCVFPRELKEVFASWKQQCLNR---GKQDISERLISASLFLRFLCPAIMS 488
Query: 1116 PDGFDIIDMTAGGQINSDQR--RNLGSVAKVLQHAASNKLFEGENEHLSSMNNYLSETYQ 1173
P F+++ Q D R R L +AKV+Q+ A+ F + E+++ MN++L +
Sbjct: 489 PSLFNLM------QEYPDDRTSRTLTLIAKVIQNLANFAKFGNKEEYMAFMNDFLEHEWG 542
Query: 1174 EFRKYFKEACNVPEPEEKFNMDKYTDLVTVSKPVIYISIEEIISTHSLLLEHQDAIAPEK 1233
+++ E N D Y DL E+ HSLL E + +
Sbjct: 543 GMKRFLLEISNPDTISNTPGFDGYIDLG-----------RELSVLHSLLWEVVSQLDKGE 591
Query: 1234 NDLLSELLGSLGEVPTVESFLGEGAVDP 1261
N L + LG +P V + + + +P
Sbjct: 592 NSFLQATVAKLGPLPRVLADITKSLTNP 619
>gi|194248068 synaptic Ras GTPase activating protein 1 [Homo sapiens]
Length = 1343
Score = 55.1 bits (131), Expect = 5e-07
Identities = 81/395 (20%), Positives = 162/395 (41%), Gaps = 48/395 (12%)
Query: 1002 TNPVEVYKAWVNQ--LETQTGEASKLPYDVTTEQALTYPEVKNKLEASIE---NLRRVTD 1056
T +E Y + Q L+ GE + Y+ +E+ +K + E NLR +
Sbjct: 491 TKAIEEYMRLIGQKYLKDAIGEFIRALYE--SEENCEVDPIKCTASSLAEHQANLRMCCE 548
Query: 1057 KVLNSIISSLDLLPYGLRYIAKVLKNSIHEKFPDATEDELLKIVGNLLYYRYMNPAIVAP 1116
L +++S + P L+ + + E+ ED +++ L+ R++ PAI++P
Sbjct: 549 LALCKVVNSHCVFPRELKEVFASWRLRCAER---GREDIADRLISASLFLRFLCPAIMSP 605
Query: 1117 DGFDIIDMTAGGQINSDQRRNLGSVAKVLQHAASNKLFEGENEHLSSMNNYLSETYQEFR 1176
F ++ Q + R L +AKV+Q+ A+ F + + L MN +L + +
Sbjct: 606 SLFGLMQEYPDEQTS----RTLTLIAKVIQNLANFSKFTSKEDFLGFMNEFLELEWGSMQ 661
Query: 1177 KYFKEACNVPEPEEKFNMDKYTDLVTVSKPVIYISIEEIISTHSLLLEHQDAIAPEKNDL 1236
++ E N+ + + Y DL E+ + H+LL E + P+ L
Sbjct: 662 QFLYEISNLDTLTNSSSFEGYIDLG-----------RELSTLHALLWE----VLPQ---L 703
Query: 1237 LSELLGSLGEVPTVESFLGEGAVDPNDPNKANTLSQLSKTEISLVLTSKYDIED------ 1290
E L LG +P + + + +PN + + S+ + + ++ +++
Sbjct: 704 SKEALLKLGPLPRLLNDISTALRNPNIQRQPSRQSERPRPQPVVLRGPSAEMQGYMMRDL 763
Query: 1291 GEAIDSRSLMIKTKKLIIDVIRNQPGNTLTEILETPATAQQEVDHATDMVSRAMIDSRTP 1350
+ID +S M + +D+ R P T + P +++ + VSR + +P
Sbjct: 764 NSSIDLQSFMARGLNSSMDMAR-LPSPTKEKPPPPPPGGGKDLFY----VSRPPLARSSP 818
Query: 1351 EEMKHSQSMIEDAQLPLEQKKRKIQRNLRTLEQTG 1385
S + E EQK + +++ L+ G
Sbjct: 819 AYCTSSSDITEP-----EQKMLSVNKSVSMLDLQG 848
>gi|4506431 RAS p21 protein activator 1 isoform 1 [Homo sapiens]
Length = 1047
Score = 54.7 bits (130), Expect = 7e-07
Identities = 44/197 (22%), Positives = 86/197 (43%), Gaps = 17/197 (8%)
Query: 1039 EVKNKLEASIENLRRVTDKVLNSIISSLDLLPYGLRYIAKVLKNSIHEKFPDATEDELLK 1098
E + ++ +L + +++ I + ++LP LRYI L+ S+ K+P T +
Sbjct: 836 EKNEDVNTNLTHLLNILSELVEKIFMASEILPPTLRYIYGCLQKSVQHKWPTNTTMR-TR 894
Query: 1099 IVGNLLYYRYMNPAIVAPDGFDIIDMTAGGQINSDQRRNLGSVAKVLQHAASNKLFEGEN 1158
+V ++ R + PAI+ P F+II + + R L VAK +Q+ A+ F +
Sbjct: 895 VVSGFVFLRLICPAILNPRMFNIISDSP----SPIAARTLILVAKSVQNLANLVEFGAKE 950
Query: 1159 EHLSSMNNYLSETYQEFRKYFKEACNVPEPEEKFNMDKYTDLVTVSKPVIYISIEEIIST 1218
++ +N ++ + E NVPE + + TDL ++ +
Sbjct: 951 PYMEGVNPFIKSNKHRMIMFLDELGNVPELPDTTEHSR-TDL-----------SRDLAAL 998
Query: 1219 HSLLLEHQDAIAPEKND 1235
H + + H D + N+
Sbjct: 999 HEICVAHSDELRTLSNE 1015
>gi|12545406 RAS p21 protein activator 1 isoform 2 [Homo sapiens]
Length = 870
Score = 54.7 bits (130), Expect = 7e-07
Identities = 44/197 (22%), Positives = 86/197 (43%), Gaps = 17/197 (8%)
Query: 1039 EVKNKLEASIENLRRVTDKVLNSIISSLDLLPYGLRYIAKVLKNSIHEKFPDATEDELLK 1098
E + ++ +L + +++ I + ++LP LRYI L+ S+ K+P T +
Sbjct: 659 EKNEDVNTNLTHLLNILSELVEKIFMASEILPPTLRYIYGCLQKSVQHKWPTNTTMR-TR 717
Query: 1099 IVGNLLYYRYMNPAIVAPDGFDIIDMTAGGQINSDQRRNLGSVAKVLQHAASNKLFEGEN 1158
+V ++ R + PAI+ P F+II + + R L VAK +Q+ A+ F +
Sbjct: 718 VVSGFVFLRLICPAILNPRMFNIISDSP----SPIAARTLILVAKSVQNLANLVEFGAKE 773
Query: 1159 EHLSSMNNYLSETYQEFRKYFKEACNVPEPEEKFNMDKYTDLVTVSKPVIYISIEEIIST 1218
++ +N ++ + E NVPE + + TDL ++ +
Sbjct: 774 PYMEGVNPFIKSNKHRMIMFLDELGNVPELPDTTEHSR-TDL-----------SRDLAAL 821
Query: 1219 HSLLLEHQDAIAPEKND 1235
H + + H D + N+
Sbjct: 822 HEICVAHSDELRTLSNE 838
>gi|41281683 disabled homolog 2 interacting protein isoform 2 [Homo
sapiens]
Length = 1065
Score = 53.9 bits (128), Expect = 1e-06
Identities = 74/301 (24%), Positives = 121/301 (40%), Gaps = 35/301 (11%)
Query: 981 LRQLLAPVVKEIIDDKSLIINTNP-----VEVYKAWVNQ--LETQTGEASKLPYDVTTEQ 1033
L L+ V D++ LI N +E Y V Q L+ GE K Y+ + E
Sbjct: 269 LTDLMMSEVDRCGDNEHLIFRENTLATKAIEEYLKLVGQKYLQDALGEFIKALYE-SDEN 327
Query: 1034 ALTYPEVKNKLEASIE--NLRRVTDKVLNSIISSLDLLPYGLRYIAKVLKNSIHEKF-PD 1090
P + + NL+ + II+S + P L+ + + + PD
Sbjct: 328 CEVDPSKCSAADLPEHQGNLKMCCELAFCKIINSYCVFPRELKEVFASWRQECSSRGRPD 387
Query: 1091 ATEDELLKIVGNLLYYRYMNPAIVAPDGFDIIDMTAGGQINSDQR--RNLGSVAKVLQHA 1148
+E +++ L+ R++ PAI++P F+++ Q D R R L +AKV Q+
Sbjct: 388 ISE----RLISASLFLRFLCPAIMSPSLFNLL------QEYPDDRTARTLTLIAKVTQNL 437
Query: 1149 ASNKLFEGENEHLSSMNNYLSETYQEFRKYFKEACNVPEPEEKFNMDKYTDLVTVSKPVI 1208
A+ F + E++S MN +L + +++ E N + Y DL
Sbjct: 438 ANFAKFGSKEEYMSFMNQFLEHEWTNMQRFLLEISNPETLSNTAGFEGYIDLG------- 490
Query: 1209 YISIEEIISTHSLLLEHQDAIAPEKNDLLSELLGSLGEVPTVESFLGEGAVDPNDPNKAN 1268
E+ S HSLL E + L L L +V T S G G + P + A+
Sbjct: 491 ----RELSSLHSLLWEAVSQLEQSIVSKLGPLPRILRDVHTALSTPGSGQL-PGTNDLAS 545
Query: 1269 T 1269
T
Sbjct: 546 T 546
>gi|94967023 disabled homolog 2 interacting protein isoform 1 [Homo
sapiens]
Length = 1132
Score = 53.9 bits (128), Expect = 1e-06
Identities = 74/301 (24%), Positives = 121/301 (40%), Gaps = 35/301 (11%)
Query: 981 LRQLLAPVVKEIIDDKSLIINTNP-----VEVYKAWVNQ--LETQTGEASKLPYDVTTEQ 1033
L L+ V D++ LI N +E Y V Q L+ GE K Y+ + E
Sbjct: 365 LTDLMMSEVDRCGDNEHLIFRENTLATKAIEEYLKLVGQKYLQDALGEFIKALYE-SDEN 423
Query: 1034 ALTYPEVKNKLEASIE--NLRRVTDKVLNSIISSLDLLPYGLRYIAKVLKNSIHEKF-PD 1090
P + + NL+ + II+S + P L+ + + + PD
Sbjct: 424 CEVDPSKCSAADLPEHQGNLKMCCELAFCKIINSYCVFPRELKEVFASWRQECSSRGRPD 483
Query: 1091 ATEDELLKIVGNLLYYRYMNPAIVAPDGFDIIDMTAGGQINSDQR--RNLGSVAKVLQHA 1148
+E +++ L+ R++ PAI++P F+++ Q D R R L +AKV Q+
Sbjct: 484 ISE----RLISASLFLRFLCPAIMSPSLFNLL------QEYPDDRTARTLTLIAKVTQNL 533
Query: 1149 ASNKLFEGENEHLSSMNNYLSETYQEFRKYFKEACNVPEPEEKFNMDKYTDLVTVSKPVI 1208
A+ F + E++S MN +L + +++ E N + Y DL
Sbjct: 534 ANFAKFGSKEEYMSFMNQFLEHEWTNMQRFLLEISNPETLSNTAGFEGYIDLG------- 586
Query: 1209 YISIEEIISTHSLLLEHQDAIAPEKNDLLSELLGSLGEVPTVESFLGEGAVDPNDPNKAN 1268
E+ S HSLL E + L L L +V T S G G + P + A+
Sbjct: 587 ----RELSSLHSLLWEAVSQLEQSIVSKLGPLPRILRDVHTALSTPGSGQL-PGTNDLAS 641
Query: 1269 T 1269
T
Sbjct: 642 T 642
>gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens]
Length = 1979
Score = 53.5 bits (127), Expect = 2e-06
Identities = 167/794 (21%), Positives = 313/794 (39%), Gaps = 123/794 (15%)
Query: 689 EQEE-NVVKIQAFWKGYKQRKEYMHRRQTFIDNTDSIVKIQSWFRMATARKSYLSRLQYF 747
EQE+ NV K Q + + E + + + +D++ + + + + + Q
Sbjct: 335 EQEQLNVEKRQIMEECENLKLECSKLQPSAVKQSDTMTEKERILAQSASVEEVFRLQQAL 394
Query: 748 RDHNNEIVKIQSLLRANKARDDYKTLVGSENPPLTVIRKFVYLLDQSDLDFQEELEVARL 807
D NEI+++ SL + N +D L + V+ K LL Q +EEL+++ L
Sbjct: 395 SDAENEIMRLSSLNQDNSLAEDNLKL----KMRIEVLEKEKSLLSQE----KEELQMSLL 446
Query: 808 R---EEVVTKIRANQQLEKDLNLMDIKIGLLVKNRITLEDVISHSKKLNKKKGGEMEILN 864
+ E V K A + + D L D+++ L K + L IS + L E+E L+
Sbjct: 447 KLNNEYEVIKSTATRDISLDSELHDLRLNLEAKEQ-ELNQSISEKETLI----AEIEELD 501
Query: 865 NTDNQGIK-------SLSKERRKTLETYQQLFYLLQTNPLYLAKLIFQMPQNKS--TKFM 915
+ + K LSK++ + +L L K + Q+ +K TK +
Sbjct: 502 RQNQEATKHMILIKDQLSKQQNEGDSIISKLKQDLNDEK----KRVHQLEDDKMDITKEL 557
Query: 916 DTVIFTLYNYASNQREEYLLLKLFKTALEEEIKSKVDQVQDIVTGNPTVIKMVVSFNRGA 975
D L + L L K LE+++++ VDQ+ N ++ K +
Sbjct: 558 DVQKEKLIQSEVALND----LHLTKQKLEDKVENLVDQLNKSQESNVSIQKENLELKEHI 613
Query: 976 R-GQNTLRQLLAPVVKEIIDD-----KSLIINTNPVEV--YKAWVNQLETQTGEASKLPY 1027
R + L ++ +++ + D K ++ EV K +++LE K+ +
Sbjct: 614 RQNEEELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLSELEQLNENLKKVAF 673
Query: 1028 DVTTEQ---ALTYPEVKNKLEASIENLRRVTDKVLNSIISSLDLLPYGLRYIAKVLKNSI 1084
DV E L +V+++LE + +++ + N+I+ +L K+ K I
Sbjct: 674 DVKMENEKLVLACEDVRHQLEECLAGNNQLSLE-KNTIVETL-----------KMEKGEI 721
Query: 1085 HEKFPDATEDELLKIVGNLLYYRYMNPAIVAPDGFDIIDMTAGGQINSDQRRNLGSVAKV 1144
E EL LL + + + T N+ RNL + A
Sbjct: 722 --------EAELCWAKKRLL------------EEANKYEKTIEELSNA---RNLNTSALQ 758
Query: 1145 LQHAASNKLFEGENEHLSSMNNYLSETYQEFRKYFKEACNVPEPEEKFNMDKYTDLVTVS 1204
L+H KL + ++ ++ + + E K K+ + E+K + T L+
Sbjct: 759 LEHEHLIKLNQKKDMEIAELKKNI-EQMDTDHKETKDVLSSSLEEQK----QLTQLINKK 813
Query: 1205 KPVIYISIEEIISTHSLLLEHQD--AIAPEKNDLLSELL----GSLGEVPTVESFLGE-- 1256
+ I IE++ S L E D + A KN++L + + SLG + + L E
Sbjct: 814 E----IFIEKLKERSSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEEL 869
Query: 1257 --------GAVDPNDPNKANTLSQLSKTEISLVLTSKYDIEDGEAIDSRSLMIKTKKLII 1308
DP +++++L+ +E+S + T K +E+ IK + II
Sbjct: 870 ERLREEQSRTAPVADPKTLDSVTELA-SEVSQLNTIKEHLEE---------EIKHHQKII 919
Query: 1309 DVIRNQPGNTLTEILETPATAQQE--VDHATDMVSRAMIDSRTPEEMKHSQSMIEDAQLP 1366
+ +NQ L + L+ E H + + EE+K Q IE +
Sbjct: 920 E-DQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKTIEQIKTQ 978
Query: 1367 LEQKKRKIQRNLRTLEQTGHVSSENKYQDILNEIAKDIRNQRIYRKLRKAELAKLQQTLN 1426
L ++++ IQ + + Q V S N +R+ + +++ EL +
Sbjct: 979 LHEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKAETERLVKGIKEREL-----EIK 1033
Query: 1427 ALNKKAAFYEEQIN 1440
LN+K +QI+
Sbjct: 1034 LLNEKNISLTKQID 1047
Score = 43.5 bits (101), Expect = 0.002
Identities = 82/367 (22%), Positives = 150/367 (40%), Gaps = 51/367 (13%)
Query: 1211 SIEEI-----ISTHSLLLEHQDAIA-PEKNDL-LSELLGSLGEVPTVESFLGEGAVDPND 1263
+IEE+ ++T +L LEH+ I +K D+ ++EL ++ ++ T + +
Sbjct: 742 TIEELSNARNLNTSALQLEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDVLSSSLE 801
Query: 1264 PNKANTLSQLSKTEISLVLTSKYDIEDGEAIDSRSLMIKTKKLIIDVIRN---------Q 1314
K T ++K EI + + + E +D S ++ +++ I +
Sbjct: 802 EQKQLT-QLINKKEIFIEKLKERSSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMKE 860
Query: 1315 PGNTLTEILE---------TPATAQQEVDHATDMVSRAM----IDSRTPEEMKHSQSMIE 1361
N L E LE P + +D T++ S I EE+KH Q +IE
Sbjct: 861 ENNHLQEELERLREEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIE 920
Query: 1362 DAQLPLEQKKRKIQRNLRTLEQTGHVSSENKYQDILNEIAKDIRNQRIYRKLRKAELAKL 1421
D Q + K+Q L++L++ E +YQ +E Q K E+ L
Sbjct: 921 D------QNQSKMQL-LQSLQEQKKEMDEFRYQ---HEQMNATHTQLFLEK--DEEIKSL 968
Query: 1422 QQTLNALNKKAAFYEE----QINYYDTYIKTCLDNLKRKNTRRSIKLDGKGEPKGAKRAK 1477
Q+T+ + K +EE Q + D + +T + +L +N L + K K
Sbjct: 969 QKTIEQI--KTQLHEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKAETERLVKGIK 1026
Query: 1478 PVKYTAAKLHEKGVLL--DIDDLQTNQFKNVTFDIIATEDVGIFDVRSKFLGVEMEKVQL 1535
+ L+EK + L ID L ++ +T II +D+ I + ++ + +
Sbjct: 1027 ERELEIKLLNEKNISLTKQIDQLSKDEVGKLT-QIIQQKDLEIQALHARISSTSHTQDVV 1085
Query: 1536 NIQDLLQ 1542
+Q LQ
Sbjct: 1086 YLQQQLQ 1092
Score = 40.8 bits (94), Expect = 0.010
Identities = 218/1150 (18%), Positives = 455/1150 (39%), Gaps = 171/1150 (14%)
Query: 177 EEISNMRKELEKYGI----QMPSFSKIGGILANELSVDEAALHAAVIAINEAVEKGIAEQ 232
EE N++ E K Q + ++ ILA SV+E V + +A+ AE
Sbjct: 348 EECENLKLECSKLQPSAVKQSDTMTEKERILAQSASVEE------VFRLQQALSD--AEN 399
Query: 233 TVVTLRNPNAVLTLVDDNLAPEYQKELWDAKKKKEENARLKNSCISEEERDAYEELLTQA 292
++ L + N +L +DNL + + E+ + +K S +S+E+
Sbjct: 400 EIMRLSSLNQDNSLAEDNLKLKMRIEVLEKEK----------SLLSQEKE---------- 439
Query: 293 EIQGNINKVNRQAAVDHINA---VIPEGDPENTLLALKKPEAQLPAVYPFAAAMYQNELF 349
E+Q ++ K+N + V A + + + + L L+ E +L + + + +
Sbjct: 440 ELQMSLLKLNNEYEVIKSTATRDISLDSELHDLRLNLEAKEQELNQ----SISEKETLIA 495
Query: 350 NLQKQNTMNYLAHEELLIAVEMLSAVALLNQALESNDLVS-VQNQLRSPAIGLNNLDKAY 408
+++ + N A + +++ + LS Q E + ++S ++ L ++ L+
Sbjct: 496 EIEELDRQNQEATKHMILIKDQLS-----KQQNEGDSIISKLKQDLNDEKKRVHQLEDDK 550
Query: 409 VERYANTLLSVKLEVLSQGQDNLS---------WNEIQNCIDMVNAQIQEENDRVVAVGY 459
++ L V+ E L Q + L+ ++++N +D +N QE N V
Sbjct: 551 MD--ITKELDVQKEKLIQSEVALNDLHLTKQKLEDKVENLVDQLNKS-QESN-----VSI 602
Query: 460 INEAIDEGNPLRTLETLLLPTAN--ISDVDPAHAQHYQDVLYHAKSQKLGD-SESVSKVL 516
E ++ +R E L N + ++ +++D L + ++ + +++S++
Sbjct: 603 QKENLELKEHIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLSELE 662
Query: 517 WLDE-IQQAVDDANVDEDRAKQWVTLVVDVN----QCLEGK-----KSSDILSVLKSSTS 566
L+E +++ D ++ ++ V DV +CL G + + I+ LK
Sbjct: 663 QLNENLKKVAFDVKMENEKL---VLACEDVRHQLEECLAGNNQLSLEKNTIVETLKMEKG 719
Query: 567 N-------ANDIIPECADKY---YDALVKAKELKSERVSSDGSWL-KLNLHKKYDY---- 611
A + E A+KY + L A+ L + + + L KLN K +
Sbjct: 720 EIEAELCWAKKRLLEEANKYEKTIEELSNARNLNTSALQLEHEHLIKLNQKKDMEIAELK 779
Query: 612 ----YYNTDSKESSWVTPESCLYKESWLTGKEIEDII--EEVTVGYIRENIWSASEELLL 665
+TD KE+ V S + K++ +I +E+ + ++E EEL
Sbjct: 780 KNIEQMDTDHKETKDVLSSSLEEQ------KQLTQLINKKEIFIEKLKERSSKLQEELDK 833
Query: 666 RFQATSSGPILREEFEARKSFLHEQEENVVKIQAFWKGYKQRKEYMHRRQTFID--NTDS 723
QA ILR+ E + L +E +Q + ++ +E R D DS
Sbjct: 834 YSQALRKNEILRQTIEEKDRSLGSMKEENNHLQ---EELERLREEQSRTAPVADPKTLDS 890
Query: 724 IVKIQSWFRMATARKSYLS-----RLQYFRDHN-NEIVKIQSLLRANKARDDYKTLVGSE 777
+ ++ S K +L + D N +++ +QSL K D+++
Sbjct: 891 VTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQM 950
Query: 778 NPPLTVIRKFVYLLDQSDLDFQEELE-VARLREEVVTKI---RANQQLEKDLNLMDIKI- 832
N T Q L+ EE++ + + E++ T++ R + Q + + K+
Sbjct: 951 NATHT----------QLFLEKDEEIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQETKVQ 1000
Query: 833 GLLVKNRITLEDVISHSKKLNKKKGGEMEILNNTDNQGIKSLSKE-RRKTLETYQQLFYL 891
L ++N D+ + K E E+ N+ SL+K+ + + + +L +
Sbjct: 1001 SLNIENGSEKHDLSKAETERLVKGIKERELEIKLLNEKNISLTKQIDQLSKDEVGKLTQI 1060
Query: 892 LQTNPLYLAKLIFQMPQNKSTKFMDTVIFTLYNYASNQREEYLLLKLFKTALEEEIKSKV 951
+Q L + L ++ T+ + + L YA +RE+ + KT +K++
Sbjct: 1061 IQQKDLEIQALHARISSTSHTQDVVYLQQQLQAYAM-EREKVFAVLNEKTRENSHLKTEY 1119
Query: 952 DQVQDIVTGNPTVIKMVVSFNR--GARGQNTLRQLLAPVVKEIIDDKSLIINTNPVEV-- 1007
++ DIV + + N+ R +++ + + +E I + S II +E+
Sbjct: 1120 HKMMDIVAAKEAALIKLQDENKKLSTRFESSGQDMF----RETIQNLSRIIREKDIEIDA 1175
Query: 1008 --YKAWVNQLETQTGEASKLPYDVTTEQALTYPEVKNKLEASIENLRRVTDKVLNSIISS 1065
K QT V + Q + ++KL+ ++ + +V+ ++
Sbjct: 1176 LSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTV--- 1232
Query: 1066 LDLLPYGLRYIAKVLKNSIH----EKFPDATEDELLKIVGNLLYYRY-MNPAIVAPDGFD 1120
+++ + L+ +H + D+ + L++ L Y N + G +
Sbjct: 1233 -----QNMQHESAQLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQE 1287
Query: 1121 IIDMTAG-GQINSDQRRNLG---------SVAKVLQHAASNKLFEGENEHLSSMNNYLSE 1170
+ + GQ+ + + LG S A +L ++ L ++E LS + L +
Sbjct: 1288 LAQVQHSIGQLCNTKDLLLGKLDIISPQLSSASLLTPQSAECLRASKSEVLSESSELLQQ 1347
Query: 1171 TYQEFRKYFKEA-CNVPEPEEKFNMDKYTDLVTVSKPVIYISIEEIISTHSLLLEHQDAI 1229
+E RK +E + +E N + +D + + + E+ S L E QD +
Sbjct: 1348 ELEELRKSLQEKDATIRTLQE--NNHRLSDSIAATSELERKEHEQTDSEIKQLKEKQDVL 1405
Query: 1230 AP--EKNDLL 1237
++ DLL
Sbjct: 1406 QKLLKEKDLL 1415
>gi|51093832 GTPase activating protein and VPS9 domains 1 [Homo
sapiens]
Length = 1487
Score = 50.1 bits (118), Expect = 2e-05
Identities = 70/340 (20%), Positives = 142/340 (41%), Gaps = 26/340 (7%)
Query: 885 YQQLFYLLQTNPLYLAKLIF---QMPQNKSTKFMDTVIFTLYNYASNQREEYLLLKLFKT 941
Y + L+ NP +A + ++ Q + + TV +LY Q +E LL++ +
Sbjct: 96 YGEFLSRLRENPRLIASSLVAGEKLNQENTQSVIYTVFTSLYGNCIMQEDESYLLQVLRY 155
Query: 942 ALEEEIKSKVDQVQDIVTGNPTVIKMVVSFNRGARGQNTL--RQLLAPVVKEIIDDKSLI 999
+E E+K + + + G + F+ G L P+++ +++D+
Sbjct: 156 LIEFELKESDNPRRLLRRGTCAFSILFKLFSEGLFSAKLFLTATLHEPIMQLLVEDED-H 214
Query: 1000 INTNPVEVYKAW-VNQLETQTGEASKLPYDVTTEQALTYPEVKNKLEASIENLRRVTDKV 1058
+ T+P ++ + + +Q E GE + +V+ +E++ L + +K
Sbjct: 215 LETDPNKLIERFSPSQQEKLFGEKGSDRF---------RQKVQEMVESNEAKLVALVNKF 265
Query: 1059 LNSIISSLDLLPYGLRYIAKVLKNSIHEKFPDATE-DELLKIVGNLLYYRYMNPAIVAPD 1117
+ + + P+ LR+I + ++ D E E+ + +LL ++ PA+V P+
Sbjct: 266 IGYLKQNTYCFPHSLRWIVSQMYKTL--SCVDRLEVGEVRAMCTDLLLACFICPAVVNPE 323
Query: 1118 GFDIIDMTAGGQINSDQRRNLGSVAKVLQHAASNKLFEGENEHLSSMNNYLSETYQEFRK 1177
+ II + IN R NL V ++LQ A EG+ SS+ + F
Sbjct: 324 QYGII---SDAPINEVARFNLMQVGRLLQQLAMTGSEEGDPRTKSSLGKFDKSCVAAFLD 380
Query: 1178 YFKEACNVPEPEEKFNMDKYTDLVTVSKPVIYISIEEIIS 1217
V P + L +S+ V+YI+ ++I+
Sbjct: 381 VVIGGRAVETPP----LSSVNLLEGLSRTVVYITYSQLIT 416
>gi|226958575 RAS protein activator like 2 isoform 2 [Homo sapiens]
Length = 1280
Score = 49.3 bits (116), Expect = 3e-05
Identities = 63/268 (23%), Positives = 109/268 (40%), Gaps = 34/268 (12%)
Query: 1000 INTNPVEVYKAWVNQ--LETQTGEASKLPYDVTTEQALTYPEV--KNKLEASIENLRRVT 1055
I T +E Y V Q L GE K Y+ + E P ++L NL+
Sbjct: 521 IATKSIEEYLKLVGQQYLHDALGEFIKALYE-SDENCEVDPSKCSSSELIDHQSNLKMCC 579
Query: 1056 DKVLNSIISSLDLLPYGLRYIAKVLKNSIHEKFPDATEDELLKIVGNLLYYRYMNPAIVA 1115
+ II+S + P L+ + K + +D +++ L+ R++ PAI++
Sbjct: 580 ELAFCKIINSYCVFPRELKEVFASWKQQCLNR---GKQDISERLISASLFLRFLCPAIMS 636
Query: 1116 PDGFDIIDMTAGGQINSDQR--RNLGSVAKVLQHAASNKLFEGENEHLSSMNNYLSETYQ 1173
P F+++ Q D R R L +AKV+Q+ A+ F + E+++ MN++L +
Sbjct: 637 PSLFNLM------QEYPDDRTSRTLTLIAKVIQNLANFAKFGNKEEYMAFMNDFLEHEWG 690
Query: 1174 EFRKYFKEACNVPEPEEKFNMDKYTDLVTVSKPVIYISIEEIISTHSLLLEHQDAIAPEK 1233
+++ E N D Y DL E+ HSLL E
Sbjct: 691 GMKRFLLEISNPDTISNTPGFDGYIDLG-----------RELSVLHSLLWE-------VV 732
Query: 1234 NDLLSELLGSLGEVPTVESFLGEGAVDP 1261
+ L + LG +P V + + + +P
Sbjct: 733 SQLDKATVAKLGPLPRVLADITKSLTNP 760
>gi|4759026 RAS protein activator like 1 [Homo sapiens]
Length = 804
Score = 49.3 bits (116), Expect = 3e-05
Identities = 44/216 (20%), Positives = 96/216 (44%), Gaps = 25/216 (11%)
Query: 977 GQNTLRQLLAPVVKEIIDDKSLIINTNPVEVYKAWVNQLETQTGEASKLPYDVTTEQALT 1036
G L ++L PV+ + ++K + ++ + G ++ + + AL+
Sbjct: 359 GMPYLHEVLKPVISRVFEEKKYME-----------LDPCKMDLGRTRRISF----KGALS 403
Query: 1037 YPEVKNKLEASIENLRRVTDKVLNSIISSLDLLPYGLRYIAKVLKNSIHEKFPDATEDEL 1096
+++ E S+ L ++++I+ S+ P +R K L + E+FP A ++
Sbjct: 404 EEQMR---ETSLGLLTGYLGPIVDAIVGSVGRCPPAMRLAFKQLHRRVEERFPQAEHQDV 460
Query: 1097 LKI-VGNLLYYRYMNPAIVAPDGFDIIDMTAGGQINSDQRRNLGSVAKVLQHAAS--NKL 1153
+ + L+ R+ PAI+ P FD+ D A Q + R+L +AK +Q + +L
Sbjct: 461 KYLAISGFLFLRFFAPAILTPKLFDLRDQHADPQTS----RSLLLLAKAVQSIGNLGQQL 516
Query: 1154 FEGENEHLSSMNNYLSETYQEFRKYFKEACNVPEPE 1189
+G+ ++ ++ +L + R + +V E
Sbjct: 517 GQGKELWMAPLHPFLLQCVSRVRDFLDRLVDVDGDE 552
>gi|217272804 hyaluronan-mediated motility receptor isoform d [Homo
sapiens]
Length = 638
Score = 48.1 bits (113), Expect = 7e-05
Identities = 104/523 (19%), Positives = 212/523 (40%), Gaps = 93/523 (17%)
Query: 342 AMYQNELFNLQKQNTMNYLAHEELLIAVEMLSA-----------VALLNQAL-ESND-LV 388
A + +L +++K+ E+LL +E +S +A L + L E ND ++
Sbjct: 124 AQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEIL 183
Query: 389 SVQNQLRSPAIGLNNLDKAYVERYANTLLSVKLEVLS-QGQDNLSWNEIQNCIDMVNAQI 447
S++ L + L+ VE L+VK ++L + +D+++ N N + +NA++
Sbjct: 184 SLKQSLEENIVILSK----QVED-----LNVKCQLLEKEKEDHVNRNREHN--ENLNAEM 232
Query: 448 QEENDRVVAVGYINEAIDEGNPLRTLETLLLPTANISDVDPAHAQHYQDVLYHAKSQKLG 507
Q + + E + + +++LL +S H K
Sbjct: 233 QNLKQKFILEQQEREKLQQKE--LQIDSLLQQEKELSSS------------LHQKLCSFQ 278
Query: 508 DSESVSKVLWLDEIQQAVDDANVDEDRAKQWVTLVVDVNQCLEGKKSSDILSVLKSSTSN 567
+ K L+ +E++Q +D+ + + + +Q LV + + E K ++ L +L+
Sbjct: 279 EEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEE--EAKSRAEELKLLEEK--- 333
Query: 568 ANDIIPECADKYYDALVKAKELKSERVSSDGSWLKLNLHKKYD---------------YY 612
+K KE + E+ S+ + L L +KYD Y
Sbjct: 334 ----------------LKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYK 377
Query: 613 YNTDSKESSWVTPESCLYKESWLTGKEIEDIIEEVTVG------YIRENIWSASEELLLR 666
T S+ S L +++ GK ED+ ++ Y+R + ++ L
Sbjct: 378 ALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKE 437
Query: 667 FQATSSGPILREEFEARKSFLHEQEENVVKIQAFWKGYKQRKEYMHRRQTFIDNTDSIVK 726
+ ++ ++ L +QEE+ K +G K KE T + T+ I K
Sbjct: 438 TEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKE-----NTTAELTEEINK 492
Query: 727 IQSWFR-MATARKSYLSRLQYFRDHNNEIVKIQSLLRA--NKARDDYKTLVGSENPPLTV 783
+ + + K + +L F ++ + NK RD Y L+G +N +
Sbjct: 493 WRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQN----L 548
Query: 784 IRKFVYLLDQSDLDFQEELEVARLREEVVTKIRANQQLEKDLN 826
+K +++ D + Q + EV++LR ++ K ++ +L+++LN
Sbjct: 549 KQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEELN 591
>gi|217272802 hyaluronan-mediated motility receptor isoform a [Homo
sapiens]
Length = 725
Score = 48.1 bits (113), Expect = 7e-05
Identities = 104/523 (19%), Positives = 212/523 (40%), Gaps = 93/523 (17%)
Query: 342 AMYQNELFNLQKQNTMNYLAHEELLIAVEMLSA-----------VALLNQAL-ESND-LV 388
A + +L +++K+ E+LL +E +S +A L + L E ND ++
Sbjct: 211 AQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEIL 270
Query: 389 SVQNQLRSPAIGLNNLDKAYVERYANTLLSVKLEVLS-QGQDNLSWNEIQNCIDMVNAQI 447
S++ L + L+ VE L+VK ++L + +D+++ N N + +NA++
Sbjct: 271 SLKQSLEENIVILSK----QVED-----LNVKCQLLEKEKEDHVNRNREHN--ENLNAEM 319
Query: 448 QEENDRVVAVGYINEAIDEGNPLRTLETLLLPTANISDVDPAHAQHYQDVLYHAKSQKLG 507
Q + + E + + +++LL +S H K
Sbjct: 320 QNLKQKFILEQQEREKLQQKE--LQIDSLLQQEKELSSS------------LHQKLCSFQ 365
Query: 508 DSESVSKVLWLDEIQQAVDDANVDEDRAKQWVTLVVDVNQCLEGKKSSDILSVLKSSTSN 567
+ K L+ +E++Q +D+ + + + +Q LV + + E K ++ L +L+
Sbjct: 366 EEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEE--EAKSRAEELKLLEEK--- 420
Query: 568 ANDIIPECADKYYDALVKAKELKSERVSSDGSWLKLNLHKKYD---------------YY 612
+K KE + E+ S+ + L L +KYD Y
Sbjct: 421 ----------------LKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYK 464
Query: 613 YNTDSKESSWVTPESCLYKESWLTGKEIEDIIEEVTVG------YIRENIWSASEELLLR 666
T S+ S L +++ GK ED+ ++ Y+R + ++ L
Sbjct: 465 ALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKE 524
Query: 667 FQATSSGPILREEFEARKSFLHEQEENVVKIQAFWKGYKQRKEYMHRRQTFIDNTDSIVK 726
+ ++ ++ L +QEE+ K +G K KE T + T+ I K
Sbjct: 525 TEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKE-----NTTAELTEEINK 579
Query: 727 IQSWFR-MATARKSYLSRLQYFRDHNNEIVKIQSLLRA--NKARDDYKTLVGSENPPLTV 783
+ + + K + +L F ++ + NK RD Y L+G +N +
Sbjct: 580 WRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQN----L 635
Query: 784 IRKFVYLLDQSDLDFQEELEVARLREEVVTKIRANQQLEKDLN 826
+K +++ D + Q + EV++LR ++ K ++ +L+++LN
Sbjct: 636 KQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEELN 678
>gi|217416398 hyaluronan-mediated motility receptor isoform c [Homo
sapiens]
Length = 709
Score = 48.1 bits (113), Expect = 7e-05
Identities = 104/523 (19%), Positives = 212/523 (40%), Gaps = 93/523 (17%)
Query: 342 AMYQNELFNLQKQNTMNYLAHEELLIAVEMLSA-----------VALLNQAL-ESND-LV 388
A + +L +++K+ E+LL +E +S +A L + L E ND ++
Sbjct: 195 AQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEIL 254
Query: 389 SVQNQLRSPAIGLNNLDKAYVERYANTLLSVKLEVLS-QGQDNLSWNEIQNCIDMVNAQI 447
S++ L + L+ VE L+VK ++L + +D+++ N N + +NA++
Sbjct: 255 SLKQSLEENIVILSK----QVED-----LNVKCQLLEKEKEDHVNRNREHN--ENLNAEM 303
Query: 448 QEENDRVVAVGYINEAIDEGNPLRTLETLLLPTANISDVDPAHAQHYQDVLYHAKSQKLG 507
Q + + E + + +++LL +S H K
Sbjct: 304 QNLKQKFILEQQEREKLQQKE--LQIDSLLQQEKELSSS------------LHQKLCSFQ 349
Query: 508 DSESVSKVLWLDEIQQAVDDANVDEDRAKQWVTLVVDVNQCLEGKKSSDILSVLKSSTSN 567
+ K L+ +E++Q +D+ + + + +Q LV + + E K ++ L +L+
Sbjct: 350 EEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEE--EAKSRAEELKLLEEK--- 404
Query: 568 ANDIIPECADKYYDALVKAKELKSERVSSDGSWLKLNLHKKYD---------------YY 612
+K KE + E+ S+ + L L +KYD Y
Sbjct: 405 ----------------LKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYK 448
Query: 613 YNTDSKESSWVTPESCLYKESWLTGKEIEDIIEEVTVG------YIRENIWSASEELLLR 666
T S+ S L +++ GK ED+ ++ Y+R + ++ L
Sbjct: 449 ALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKE 508
Query: 667 FQATSSGPILREEFEARKSFLHEQEENVVKIQAFWKGYKQRKEYMHRRQTFIDNTDSIVK 726
+ ++ ++ L +QEE+ K +G K KE T + T+ I K
Sbjct: 509 TEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKE-----NTTAELTEEINK 563
Query: 727 IQSWFR-MATARKSYLSRLQYFRDHNNEIVKIQSLLRA--NKARDDYKTLVGSENPPLTV 783
+ + + K + +L F ++ + NK RD Y L+G +N +
Sbjct: 564 WRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQN----L 619
Query: 784 IRKFVYLLDQSDLDFQEELEVARLREEVVTKIRANQQLEKDLN 826
+K +++ D + Q + EV++LR ++ K ++ +L+++LN
Sbjct: 620 KQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEELN 662
>gi|217416394 hyaluronan-mediated motility receptor isoform b [Homo
sapiens]
Length = 724
Score = 48.1 bits (113), Expect = 7e-05
Identities = 104/523 (19%), Positives = 212/523 (40%), Gaps = 93/523 (17%)
Query: 342 AMYQNELFNLQKQNTMNYLAHEELLIAVEMLSA-----------VALLNQAL-ESND-LV 388
A + +L +++K+ E+LL +E +S +A L + L E ND ++
Sbjct: 210 AQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEIL 269
Query: 389 SVQNQLRSPAIGLNNLDKAYVERYANTLLSVKLEVLS-QGQDNLSWNEIQNCIDMVNAQI 447
S++ L + L+ VE L+VK ++L + +D+++ N N + +NA++
Sbjct: 270 SLKQSLEENIVILSK----QVED-----LNVKCQLLEKEKEDHVNRNREHN--ENLNAEM 318
Query: 448 QEENDRVVAVGYINEAIDEGNPLRTLETLLLPTANISDVDPAHAQHYQDVLYHAKSQKLG 507
Q + + E + + +++LL +S H K
Sbjct: 319 QNLKQKFILEQQEREKLQQKE--LQIDSLLQQEKELSSS------------LHQKLCSFQ 364
Query: 508 DSESVSKVLWLDEIQQAVDDANVDEDRAKQWVTLVVDVNQCLEGKKSSDILSVLKSSTSN 567
+ K L+ +E++Q +D+ + + + +Q LV + + E K ++ L +L+
Sbjct: 365 EEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEE--EAKSRAEELKLLEEK--- 419
Query: 568 ANDIIPECADKYYDALVKAKELKSERVSSDGSWLKLNLHKKYD---------------YY 612
+K KE + E+ S+ + L L +KYD Y
Sbjct: 420 ----------------LKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYK 463
Query: 613 YNTDSKESSWVTPESCLYKESWLTGKEIEDIIEEVTVG------YIRENIWSASEELLLR 666
T S+ S L +++ GK ED+ ++ Y+R + ++ L
Sbjct: 464 ALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKE 523
Query: 667 FQATSSGPILREEFEARKSFLHEQEENVVKIQAFWKGYKQRKEYMHRRQTFIDNTDSIVK 726
+ ++ ++ L +QEE+ K +G K KE T + T+ I K
Sbjct: 524 TEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKE-----NTTAELTEEINK 578
Query: 727 IQSWFR-MATARKSYLSRLQYFRDHNNEIVKIQSLLRA--NKARDDYKTLVGSENPPLTV 783
+ + + K + +L F ++ + NK RD Y L+G +N +
Sbjct: 579 WRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQN----L 634
Query: 784 IRKFVYLLDQSDLDFQEELEVARLREEVVTKIRANQQLEKDLN 826
+K +++ D + Q + EV++LR ++ K ++ +L+++LN
Sbjct: 635 KQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEELN 677
>gi|205277396 dynactin 1 isoform 4 [Homo sapiens]
Length = 1139
Score = 47.4 bits (111), Expect = 1e-04
Identities = 69/341 (20%), Positives = 131/341 (38%), Gaps = 38/341 (11%)
Query: 1168 LSETYQEFRKYFKEACNVPEP--EEKFNMDKYTDLVTVSKPVIYISIEEIISTHSLLLEH 1225
L +E RK KEA E EE + ++ T+ K + E + L E
Sbjct: 138 LQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKER 197
Query: 1226 QDAIAPEKNDLLSELLGSLGEVPTVESFLGEGAVDPNDPNKANTLSQLSKTEISL--VLT 1283
D + + L +E +E +GA + L QL + L L
Sbjct: 198 VDELTTDLEILKAE----------IEEKGSDGAAS------SYQLKQLEEQNARLKDALV 241
Query: 1284 SKYDIEDGEAIDSRSL--MIKTKKLIIDVIRNQPGNTLTEILETPATAQQEVDHATDMVS 1341
D+ E + L +++ K ++V+R Q E+ + +T +D + V
Sbjct: 242 RMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAEST----IDELKEQVD 297
Query: 1342 RAMIDSRTPEEMKHSQSMIEDAQLPLEQKKRKIQRNLRTLEQTGHVSSENKYQDILNEIA 1401
A+ EEM M+ D L LE+K R+++ + LE ++ E Q+ E
Sbjct: 298 AAL----GAEEMVE---MLTDRNLNLEEKVRELRETVGDLEAMNEMNDE--LQENARETE 348
Query: 1402 KDIRNQRIYRKLRKAELAKLQQTLNALNKKAAFYEEQINYYDTYIKTCLDNLKRKNTRRS 1461
++R Q + A + + Q+ + A + A Y++ I Y D + ++
Sbjct: 349 LELREQL---DMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQE 405
Query: 1462 IKLDGKGEPKGAKRAKPVKYTAAKLHEKGVLLDIDDLQTNQ 1502
++ + +P +K+ K H K + +++ ++ Q
Sbjct: 406 ASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQ 446
>gi|205277392 dynactin 1 isoform 3 [Homo sapiens]
Length = 1253
Score = 47.4 bits (111), Expect = 1e-04
Identities = 69/341 (20%), Positives = 131/341 (38%), Gaps = 38/341 (11%)
Query: 1168 LSETYQEFRKYFKEACNVPEP--EEKFNMDKYTDLVTVSKPVIYISIEEIISTHSLLLEH 1225
L +E RK KEA E EE + ++ T+ K + E + L E
Sbjct: 252 LQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKER 311
Query: 1226 QDAIAPEKNDLLSELLGSLGEVPTVESFLGEGAVDPNDPNKANTLSQLSKTEISL--VLT 1283
D + + L +E +E +GA + L QL + L L
Sbjct: 312 VDELTTDLEILKAE----------IEEKGSDGAAS------SYQLKQLEEQNARLKDALV 355
Query: 1284 SKYDIEDGEAIDSRSL--MIKTKKLIIDVIRNQPGNTLTEILETPATAQQEVDHATDMVS 1341
D+ E + L +++ K ++V+R Q E+ + +T +D + V
Sbjct: 356 RMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAEST----IDELKEQVD 411
Query: 1342 RAMIDSRTPEEMKHSQSMIEDAQLPLEQKKRKIQRNLRTLEQTGHVSSENKYQDILNEIA 1401
A+ EEM M+ D L LE+K R+++ + LE ++ E Q+ E
Sbjct: 412 AAL----GAEEMVE---MLTDRNLNLEEKVRELRETVGDLEAMNEMNDE--LQENARETE 462
Query: 1402 KDIRNQRIYRKLRKAELAKLQQTLNALNKKAAFYEEQINYYDTYIKTCLDNLKRKNTRRS 1461
++R Q + A + + Q+ + A + A Y++ I Y D + ++
Sbjct: 463 LELREQL---DMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQE 519
Query: 1462 IKLDGKGEPKGAKRAKPVKYTAAKLHEKGVLLDIDDLQTNQ 1502
++ + +P +K+ K H K + +++ ++ Q
Sbjct: 520 ASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQ 560
>gi|13259508 dynactin 1 isoform 2 [Homo sapiens]
Length = 1144
Score = 47.4 bits (111), Expect = 1e-04
Identities = 69/341 (20%), Positives = 131/341 (38%), Gaps = 38/341 (11%)
Query: 1168 LSETYQEFRKYFKEACNVPEP--EEKFNMDKYTDLVTVSKPVIYISIEEIISTHSLLLEH 1225
L +E RK KEA E EE + ++ T+ K + E + L E
Sbjct: 138 LQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKER 197
Query: 1226 QDAIAPEKNDLLSELLGSLGEVPTVESFLGEGAVDPNDPNKANTLSQLSKTEISL--VLT 1283
D + + L +E +E +GA + L QL + L L
Sbjct: 198 VDELTTDLEILKAE----------IEEKGSDGAAS------SYQLKQLEEQNARLKDALV 241
Query: 1284 SKYDIEDGEAIDSRSL--MIKTKKLIIDVIRNQPGNTLTEILETPATAQQEVDHATDMVS 1341
D+ E + L +++ K ++V+R Q E+ + +T +D + V
Sbjct: 242 RMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAEST----IDELKEQVD 297
Query: 1342 RAMIDSRTPEEMKHSQSMIEDAQLPLEQKKRKIQRNLRTLEQTGHVSSENKYQDILNEIA 1401
A+ EEM M+ D L LE+K R+++ + LE ++ E Q+ E
Sbjct: 298 AAL----GAEEMVE---MLTDRNLNLEEKVRELRETVGDLEAMNEMNDE--LQENARETE 348
Query: 1402 KDIRNQRIYRKLRKAELAKLQQTLNALNKKAAFYEEQINYYDTYIKTCLDNLKRKNTRRS 1461
++R Q + A + + Q+ + A + A Y++ I Y D + ++
Sbjct: 349 LELREQL---DMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQE 405
Query: 1462 IKLDGKGEPKGAKRAKPVKYTAAKLHEKGVLLDIDDLQTNQ 1502
++ + +P +K+ K H K + +++ ++ Q
Sbjct: 406 ASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQ 446
>gi|13259510 dynactin 1 isoform 1 [Homo sapiens]
Length = 1278
Score = 47.4 bits (111), Expect = 1e-04
Identities = 69/341 (20%), Positives = 131/341 (38%), Gaps = 38/341 (11%)
Query: 1168 LSETYQEFRKYFKEACNVPEP--EEKFNMDKYTDLVTVSKPVIYISIEEIISTHSLLLEH 1225
L +E RK KEA E EE + ++ T+ K + E + L E
Sbjct: 272 LQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKER 331
Query: 1226 QDAIAPEKNDLLSELLGSLGEVPTVESFLGEGAVDPNDPNKANTLSQLSKTEISL--VLT 1283
D + + L +E +E +GA + L QL + L L
Sbjct: 332 VDELTTDLEILKAE----------IEEKGSDGAAS------SYQLKQLEEQNARLKDALV 375
Query: 1284 SKYDIEDGEAIDSRSL--MIKTKKLIIDVIRNQPGNTLTEILETPATAQQEVDHATDMVS 1341
D+ E + L +++ K ++V+R Q E+ + +T +D + V
Sbjct: 376 RMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAEST----IDELKEQVD 431
Query: 1342 RAMIDSRTPEEMKHSQSMIEDAQLPLEQKKRKIQRNLRTLEQTGHVSSENKYQDILNEIA 1401
A+ EEM M+ D L LE+K R+++ + LE ++ E Q+ E
Sbjct: 432 AAL----GAEEMVE---MLTDRNLNLEEKVRELRETVGDLEAMNEMNDE--LQENARETE 482
Query: 1402 KDIRNQRIYRKLRKAELAKLQQTLNALNKKAAFYEEQINYYDTYIKTCLDNLKRKNTRRS 1461
++R Q + A + + Q+ + A + A Y++ I Y D + ++
Sbjct: 483 LELREQL---DMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQE 539
Query: 1462 IKLDGKGEPKGAKRAKPVKYTAAKLHEKGVLLDIDDLQTNQ 1502
++ + +P +K+ K H K + +++ ++ Q
Sbjct: 540 ASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQ 580
>gi|126116596 asp (abnormal spindle)-like, microcephaly associated
[Homo sapiens]
Length = 3477
Score = 45.8 bits (107), Expect = 3e-04
Identities = 38/164 (23%), Positives = 71/164 (43%), Gaps = 22/164 (13%)
Query: 684 KSFLHEQEENVVKIQAFWKGYKQRKEYMHRRQTFID-----------NTDSIVKIQSWFR 732
K + EQ + + IQ K +K RK Y+H R T + T +++ IQS++R
Sbjct: 2618 KKQIQEQHQAAIIIQKHCKAFKIRKHYLHLRATVVSIQRRYRKLTAVRTQAVICIQSYYR 2677
Query: 733 MATARKSYLSRLQYFRDHNNEIVKIQSLLRANKARDDYKTLVGSENPPLTVIRKFVYLLD 792
RK ++ + IQS R ++A+ DY+T + + VI+ + L
Sbjct: 2678 GFKVRKD-------IQNMHRAATLIQSFYRMHRAKVDYET----KKTAIVVIQNYYRLYV 2726
Query: 793 QSDLDFQEELEVARLREEVVTKIRANQQLEKDLNLMDIKIGLLV 836
+ + + L V + + R + +K N+ + K+ +V
Sbjct: 2727 RVKTERKNFLAVQKSVRTIQAAFRGMKVRQKLKNVSEEKMAAIV 2770
Score = 40.8 bits (94), Expect = 0.010
Identities = 23/85 (27%), Positives = 46/85 (54%), Gaps = 14/85 (16%)
Query: 689 EQEENVVKIQAFWKGYKQRKEYMHRRQTFIDNTDSIVKIQSWFRMATARKSYLSRLQ--- 745
+ E+ +K+QAF +GY RK+ +R+ +++ +QS+FRM AR+ YL +
Sbjct: 1727 QMRESCIKLQAFVRGYLVRKQMRLQRK-------AVISLQSYFRMRKARQYYLKMYKAII 1779
Query: 746 ----YFRDHNNEIVKIQSLLRANKA 766
Y+ + ++ + ++ L+ KA
Sbjct: 1780 VIQNYYHAYKAQVNQRKNFLQVKKA 1804
Score = 40.4 bits (93), Expect = 0.014
Identities = 25/84 (29%), Positives = 46/84 (54%), Gaps = 12/84 (14%)
Query: 662 ELLLRFQATSSGPILREE----FEARKSFLHEQEENVVKIQAFWKGYKQRKEYMHRRQTF 717
++L +Q T S I+ + +ARK ++H +V+KIQ++++ Y +KE F
Sbjct: 1624 KVLASYQKTRSAVIVLQSAYRGMQARKMYIHILT-SVIKIQSYYRAYVSKKE-------F 1675
Query: 718 IDNTDSIVKIQSWFRMATARKSYL 741
+ ++ +K+QS +M RK YL
Sbjct: 1676 LSLKNATIKLQSTVKMKQTRKQYL 1699
Score = 40.4 bits (93), Expect = 0.014
Identities = 24/78 (30%), Positives = 40/78 (51%), Gaps = 15/78 (19%)
Query: 668 QATSSGPILREEFEARKSFLHEQEENVVKIQAFWKGYKQRKEYMHRRQTFIDNTDSIVKI 727
QA S G I + +F+ E + + +KIQA W+ Y+ +K ++ + KI
Sbjct: 2917 QARSKGFIQKRKFQ-------EIKNSTIKIQAMWRRYRAKK--------YLCKVKAACKI 2961
Query: 728 QSWFRMATARKSYLSRLQ 745
Q+W+R A K YL+ L+
Sbjct: 2962 QAWYRCWRAHKEYLAILK 2979
Score = 39.7 bits (91), Expect = 0.023
Identities = 22/77 (28%), Positives = 41/77 (53%), Gaps = 14/77 (18%)
Query: 694 VVKIQAFWKGYKQRKEYMHRRQTFIDNTDSIVKIQSWFRMATARKSYLSRLQYFRDHNNE 753
V+ +Q+ ++G + RK Y+H S++KIQS++R ++K +LS N
Sbjct: 1636 VIVLQSAYRGMQARKMYIHI-------LTSVIKIQSYYRAYVSKKEFLSL-------KNA 1681
Query: 754 IVKIQSLLRANKARDDY 770
+K+QS ++ + R Y
Sbjct: 1682 TIKLQSTVKMKQTRKQY 1698
Score = 36.6 bits (83), Expect = 0.20
Identities = 24/84 (28%), Positives = 40/84 (47%), Gaps = 10/84 (11%)
Query: 684 KSFLHEQEENVVKIQAFWKGYKQRKEYMHRRQTFIDNTDSIVKIQSWFRMATARKSYLSR 743
+ + +Q +KIQ+ ++GY +R +Y Q SI+KIQ W+R A K+
Sbjct: 1818 RQLIKQQSIAALKIQSAFRGYNKRVKYQSVLQ-------SIIKIQRWYR---AYKTLHDT 1867
Query: 744 LQYFRDHNNEIVKIQSLLRANKAR 767
+F ++ +QS R K R
Sbjct: 1868 RTHFLKTKAAVISLQSAYRGWKVR 1891
Score = 35.0 bits (79), Expect = 0.57
Identities = 35/119 (29%), Positives = 53/119 (44%), Gaps = 25/119 (21%)
Query: 694 VVKIQAFWKGYKQRKEY--MHRRQTFIDNT--------------DSIVKIQSWFRMATAR 737
V+KIQ+ ++ + RK MHR TFI +T + V IQ ++ A
Sbjct: 2315 VIKIQSSYRRWMIRKRMREMHRAATFIQSTFRMHRLHMRYQALKQASVVIQQQYQANRAA 2374
Query: 738 KSYLSRLQYFRDHNNEIVKIQSLLRANKARDDYK------TLVGSENPPLTVIRKFVYL 790
K L R Y R ++ ++ +Q+ R K R K TL+ S L V R+F+ L
Sbjct: 2375 K--LQRQHYLRQRHSAVI-LQAAFRGMKTRRHLKSMHSSATLIQSRFRSLLVRRRFISL 2430
Score = 33.1 bits (74), Expect = 2.2
Identities = 20/60 (33%), Positives = 34/60 (56%), Gaps = 8/60 (13%)
Query: 681 EARKSFLHEQEENVVKIQAFWKGYKQRKEYMHRRQTFIDNTDSIVKIQSWFRMATARKSY 740
+ R FL + + V+ +Q+ ++G+K RK+ Q + +KIQS FRMA A+K +
Sbjct: 1866 DTRTHFL-KTKAAVISLQSAYRGWKVRKQIRREHQ-------AALKIQSAFRMAKAQKQF 1917
Score = 31.2 bits (69), Expect = 8.3
Identities = 22/76 (28%), Positives = 34/76 (44%), Gaps = 10/76 (13%)
Query: 697 IQAFWKGYKQRKEYMHRRQTFIDNTDSIVKIQSWFRMATARKSYLSRLQYFRDHNNEIVK 756
IQ +++ Y +E H ++ ++V +QS +R RK +D N V
Sbjct: 2000 IQKYYRAYSIGREQNH---LYLKTKAAVVTLQSAYRGMKVRKR-------IKDCNKAAVT 2049
Query: 757 IQSLLRANKARDDYKT 772
IQS RA K + Y T
Sbjct: 2050 IQSKYRAYKTKKKYAT 2065
>gi|51972208 leucine, glutamate and lysine rich 1 [Homo sapiens]
Length = 388
Score = 41.6 bits (96), Expect = 0.006
Identities = 57/279 (20%), Positives = 123/279 (44%), Gaps = 23/279 (8%)
Query: 1171 TYQEFRKYFKEACNVPEPEE---KFNMDKYTDLVTVSKPVIYISIEEIISTHS----LLL 1223
T Q+ K +E V E +E K ++ + + ++K ++ + EE+++ + +L+
Sbjct: 12 TCQQIYKALQEELTVKEKQEEDIKRRINLAENELEITKTLLNQTREEVLTLKNERELMLI 71
Query: 1224 EHQDAIAPEKNDLLSELLGSLGEVPTVESFLGEGAVDP--NDPNKANTLSQLSKTEISLV 1281
HQ +I + L +LL +E+ L + +A + +K ++ +
Sbjct: 72 SHQKSIEQLQETLRQKLLSDDNWKEKIEAELAKERAQHLVEFEEQALLFKEETKLQLDIE 131
Query: 1282 LTSKYDIEDGEAIDSRSLMIKTKKLIIDVIRN--QPGNTLTEIL--------ETPATAQQ 1331
D+ + L +K LI R+ Q TL E L E + ++
Sbjct: 132 KEKHQDVIQKYKKEQEELQMKISDLITGATRDLRQEVTTLKEKLHKSHTRYTEESNSKEK 191
Query: 1332 EVDHATDMVSRAMIDSRTPEEMKHSQSMIEDAQLPLEQKKRKIQRNLRTLEQTGHVSSEN 1391
E+++ ++V A +SR +E+ + S+ E+ + +EQK +++R + L QT + N
Sbjct: 192 EIENLKNLV--AEFESRLKKEIDSNDSVSENLRKEMEQKSDELKRVM--LAQTQLIEQFN 247
Query: 1392 KYQDILNEIAKDIRNQRIYRKLRKAELAKLQQTLNALNK 1430
+ Q+ + + +R + R L++ ++ L L+K
Sbjct: 248 QSQEENTFLQETVRRECEERFELTEALSQAREQLLELSK 286
>gi|38176300 nestin [Homo sapiens]
Length = 1621
Score = 40.8 bits (94), Expect = 0.010
Identities = 36/143 (25%), Positives = 65/143 (45%), Gaps = 15/143 (10%)
Query: 1327 ATAQQEVDHATDMVSRAMIDSRTPEEMKHSQSMIEDAQLPLEQKKRKIQRNLRTLEQTGH 1386
++ QQE+ D+ + + DS+ P E + +S+ E+ IQ +L+TLE H
Sbjct: 517 SSLQQEIWEEEDLNRKEIQDSQVPLEKETLKSLGEE-----------IQESLKTLENQSH 565
Query: 1387 VSSENKYQDILNEIAKDIRNQRIYRKLRKAELAKLQQTLNALNKKAAFYEEQINYYDTYI 1446
+ E + Q+ + +D+ + K K EL K + + L K+A + DT
Sbjct: 566 ETLERENQECPRSLEEDLETLKSLEKENK-ELLKDVEVVRPLEKEAVGQLKPTGKEDT-- 622
Query: 1447 KTCLDNLKRKNTRRSIKLDGKGE 1469
L +L+++N L+G E
Sbjct: 623 -QTLQSLQKENQELMKSLEGNLE 644
>gi|150010558 myosin, heavy polypeptide 15 [Homo sapiens]
Length = 1946
Score = 40.8 bits (94), Expect = 0.010
Identities = 141/835 (16%), Positives = 336/835 (40%), Gaps = 112/835 (13%)
Query: 639 EIEDIIEEVTVGYIRENIWSASEELLLRFQATSSGPILREEFEARK-SFLHEQEENVVKI 697
+I+ +++ VG E + EE +A REE +A++ S E+ + ++++
Sbjct: 847 KIKPLVKSSEVG---EEVAGLKEECAQLQKALEKSEFQREELKAKQVSLTQEKNDLILQL 903
Query: 698 QAFWKGYKQRKEYMHRRQTFIDNTDSIVK--IQSWFRMATARKSYLSRLQYFRDHNNEIV 755
QA Q + N + + I+S ++ K R++ + N+E+
Sbjct: 904 QA--------------EQETLANVEEQCEWLIKSKIQLEARVKELSERVEEEEEINSELT 949
Query: 756 ----KIQS-LLRANKARDDYKT-LVGSENPPLTVIRKFVYLLDQSDLDFQEELEVARLRE 809
K++ K DD +T LV SE T K L ++ ++F E ++++L
Sbjct: 950 ARGRKLEDECFELKKEIDDLETMLVKSEKEKRTTEHKVKNLTEE--VEFLNE-DISKLNR 1006
Query: 810 EVVTKIRANQQLEKDLNLMDIKIGLLVKNRITLEDVISHSK-KLNKKKGGEMEILNNTDN 868
A+QQ DL++ + K+ L K + LE + + L +++ M
Sbjct: 1007 AAKVVQEAHQQTLDDLHMEEEKLSSLSKANLKLEQQVDELEGALEQERKARMNCERELHK 1066
Query: 869 -QGIKSLSKERRKTLETYQQ-LFYLLQTNPLYLAKLIFQMPQ--------NKSTKFMDTV 918
+G L++E + LE+ Q+ L L+ L L+++ ++ K+ K + T
Sbjct: 1067 LEGNLKLNRESMENLESSQRHLAEELRKKELELSQMNSKVENEKGLVAQLQKTVKELQTQ 1126
Query: 919 IFTLYNYASNQREEYLLLKLFKTALEEEIKSKVDQVQDIVTGNPTVIKMVVSFNRGARGQ 978
I L +R ++ + L +++ ++++++ G ++ ++ ++ + + Q
Sbjct: 1127 IKDLKEKLEAERTTRAKMERERADLTQDLADLNERLEEV--GGSSLAQLEITKKQETKFQ 1184
Query: 979 NTLRQLLAPVVKEIIDDKSLIINTNPVEVYKAWVNQLETQTGEASKLPYDVTTEQALTYP 1038
R + ++ +L T + K + L G+ L
Sbjct: 1185 KLHRDM---------EEATLHFETTSASLKKRHADSLAELEGQVENL------------Q 1223
Query: 1039 EVKNKLEASIENLRRVTDKVLNSIISSLDLLPYGLRYIAKVLKNSIHEKFPDATEDELLK 1098
+VK KLE +L+ D +L + + + + + +HE A D++ +
Sbjct: 1224 QVKQKLEKDKSDLQLEVDDLLTR-VEQMTRAKANAEKLCTLYEERLHE--ATAKLDKVTQ 1280
Query: 1099 IVGNLLYYRYMNPAIVAPDGFDIIDMTAGGQINSDQRRNLGSVAKVLQHAASNKLFEGEN 1158
+ +L + + + G + + + + R + + ++ E E
Sbjct: 1281 LANDLAAQK---TKLWSESGEFLRRLEEKEALINQLSREKSNFTRQIEDLRGQ--LEKET 1335
Query: 1159 EHLSSMNNYLSETYQE---FRKYFKEACNVPEPEEKFNMDKYTDLVTVSKPVIYISIEEI 1215
+ S++ + L + ++ R+ ++E E E K + + T+SK V ++
Sbjct: 1336 KSQSALAHALQKAQRDCDLLREQYEE-----EQEVKAELHR-----TLSK-VNAEMVQWR 1384
Query: 1216 ISTHSLLLEHQDAIAPEKNDL---LSELLGSLGEVPTVESFLGEGAVDPNDPNKANTLSQ 1272
+ + +++ + + K +L L E ++G V + E A + LS
Sbjct: 1385 MKYENNVIQRTEDLEDAKKELAIRLQEAAEAMG-VANARNASLERARHQLQLELGDALSD 1443
Query: 1273 LSKTEISLVLTSKYDIEDGEAIDSRSLMIKTKKLIIDVIRNQPGNTLTEILETPATAQQE 1332
L K + + ++ G+A+ + + ++D + + TE+L+ T ++
Sbjct: 1444 LGKVRSAAARLDQKQLQSGKALADWKQKHEESQALLDASQKEVQALSTELLKLKNTYEES 1503
Query: 1333 V--------------DHATDMVSRAMIDSRTPEEMKHSQSMIE----DAQLPLEQKKRKI 1374
+ + +++ ++ ++ EM+ + +IE + Q+ LE+ + +
Sbjct: 1504 IVGQETLRRENKNLQEEISNLTNQVREGTKNLTEMEKVKKLIEEEKTEVQVTLEETEGAL 1563
Query: 1375 QRNLRTL--EQTGHVSSENKYQDILNEIAKDIRNQRIYRKLRKAELAKLQQTLNA 1427
+RN + Q + ++ + + L+E ++I N +R+ ++ + LQ +L++
Sbjct: 1564 ERNESKILHFQLELLEAKAELERKLSEKDEEIEN---FRRKQQCTIDSLQSSLDS 1615
>gi|130502162 RAS protein activator like 3 [Homo sapiens]
Length = 1011
Score = 40.8 bits (94), Expect = 0.010
Identities = 35/121 (28%), Positives = 56/121 (46%), Gaps = 9/121 (7%)
Query: 1051 LRRVTDKVLNSIISSLDLLPYGLRYIAKVLKNSIHEKFPDATEDELLKIVGNLLYYRYMN 1110
LR ++V +II S D P L + + + E+ + L V L+ R +
Sbjct: 558 LRNSCEEVFETIIHSYDWFPAELGIVFSSWREACKERGSEVLGPRL---VCASLFLRLLC 614
Query: 1111 PAIVAPDGFDII-DMTAGGQINSDQRRNLGSVAKVLQHAASNKLFEGENEHLSSMNNYLS 1169
PAI+AP F + D A G R L +AKV+Q+ A+ F + ++ MN++L
Sbjct: 615 PAILAPSLFGLAPDHPAPGPA-----RTLTLIAKVIQNLANRAPFGEKEAYMGFMNSFLE 669
Query: 1170 E 1170
E
Sbjct: 670 E 670
>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
Length = 1684
Score = 40.4 bits (93), Expect = 0.014
Identities = 167/912 (18%), Positives = 347/912 (38%), Gaps = 171/912 (18%)
Query: 164 QIQDLLGKVDFTEEEISNMRKELEKYGIQMPSFSKIGGILANELSVDEAALHAAVIAINE 223
++ +L G ++ T +E ++LEK +QM LS D+ L A V ++ E
Sbjct: 644 KVNELTGGLEETLKEKDQNDQKLEKLMVQM-----------KVLSEDKEVLSAEVKSLYE 692
Query: 224 AVEKGIAEQTVVTLRNPNAVLTLVDDNLAPEYQKELWDAKKKKEENARLKNSCISEEERD 283
K +E+ ++ R+ L+ +D + E+ +L +KK + +++ E +
Sbjct: 693 ENNKLSSEKKQLS-RDLEVFLSQKEDVILKEHITQL---EKKLQLMVEEQDNLNKLLENE 748
Query: 284 AYEELLTQAEIQGNINKVNRQAAVDHINAVIPEGDPENTLLALKKPEAQLPAVYPFAAAM 343
++L + ++ G + ++ + + D E D N L A+ + A++ A
Sbjct: 749 QVQKLFVKTQLYGFLKEMGSEVSEDS-----EEKDVVNVLQAVGESLAKINEEKCNLAFQ 803
Query: 344 YQNELFNLQKQNTMNYLAHEELLIAVEMLSAV-------ALLNQALESNDLVSVQNQLRS 396
++ L+K+ + L E ++ E+ S + LL + LE ++ S + L+S
Sbjct: 804 RDEKVLELEKE--IKCLQEESVVQCEELKSLLRDYEQEKVLLRKELE--EIQSEKEALQS 859
Query: 397 PAIGLNNLDKAYVERYANTLLSVKLEVLSQGQDNLS-WNEIQNCI--------------- 440
+ + N ++ R N L +++E +SQ NE + C
Sbjct: 860 DLLEMKNANEK--TRLENQNLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKE 917
Query: 441 ------------DMVNAQIQEENDRVVAVGYINEAID--------EGNPLRTLETLLLPT 480
D + +ND + +V + E I+ + + ++ + +
Sbjct: 918 LRDRRAELILLKDSLAKSPSVKNDPLSSVKELEEKIENLEKECKEKEEKINKIKLVAVKA 977
Query: 481 ANISDVDPAHAQHYQDVLYHAKSQKLGDSESVSKVLW--------LDEIQQAVDDANVDE 532
D Q ++ L +S+K S S+ ++ L E ++ + +V++
Sbjct: 978 KKELDSSRKETQTVKEELESLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEK 1037
Query: 533 DRAKQWVTLVVDVNQCLEGKK---------SSDILSVLKSSTSNANDIIPECADKYYDAL 583
+RA + + D+ + L + D+L+ +++ SNA + + +
Sbjct: 1038 ERANNFEHRIEDLTRQLRNSTLQCETINSDNEDLLARIETLQSNAKLLEVQILEVQRAKA 1097
Query: 584 VKAKELKSERVSSDGSWLK----LNLHKKYDYYYNTDSKESSWVTPESCLYK----ESWL 635
+ KEL++E++ + + +N ++ + K+ E L K ++ L
Sbjct: 1098 MVDKELEAEKLQKEQKIKEHATTVNELEELQVQLQKEKKQLQKTMQELELVKKDAQQTTL 1157
Query: 636 TGKEIED---IIEEVTVGYIREN--IWSASEELLLRFQATSSGPILREEFEARKSFLHEQ 690
EI D +++E+ +N I +E+ ++ Q + L+EE + +S + +
Sbjct: 1158 MNMEIADYERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQET---LQEEITSLQSSVQQY 1214
Query: 691 EENVVKIQAFWKGYKQRKEYMHRRQTFIDNTD----------------SIVKIQSWFRMA 734
EE KI+ K +KE +Q D+ + KIQ +
Sbjct: 1215 EEKNTKIKQLL--VKTKKELADSKQAETDHLILQASLKGELEASQQQVEVYKIQLAEITS 1272
Query: 735 TARKSY----LSRLQYFRD---HNNEIVKIQSLLRANKARDDYKTLVGSENPPLTVIRKF 787
K + S Q+ R + + +Q RA KA + V SE V
Sbjct: 1273 EKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEECRAAKAE---QATVTSEFESYKVRVHN 1329
Query: 788 VYLLDQSDLDFQEELEVARLREEVVTKI--RANQQLEKDLNLMDIKIG-----------L 834
V ++ Q E E A+ E + + + +L+ N + I + L
Sbjct: 1330 VLKQQKNKSMSQAETEGAKQEREHLEMLIDQLKIKLQDSQNNLQINVSELQTLQSEHDTL 1389
Query: 835 LVKNRITLEDVISHSKKLNKKK---------------------GGEMEILNNTDNQGIKS 873
L ++ L++ +S +L +K + E+L N+ ++
Sbjct: 1390 LERHNKMLQETVSKEAELREKLCSIQSENMMMKSEHTQTVSQLTSQNEVLRNSFRDQVRH 1449
Query: 874 LSKERRKTLETYQQLFYLLQTNPLYLAKLIFQMPQNKSTKFMDTVIFTLYNYASNQREEY 933
L +E RKT+ET QQ ++ +FQ+ +T+ + +L N + +
Sbjct: 1450 LQEEHRKTVETLQQQLSKMEAQ-------LFQLKNEPTTRSPVSSQQSLKNLRERRNTDL 1502
Query: 934 LLLKLFKTALEE 945
LL + EE
Sbjct: 1503 PLLDMHTVTREE 1514
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 40.0 bits (92), Expect = 0.018
Identities = 160/862 (18%), Positives = 334/862 (38%), Gaps = 144/862 (16%)
Query: 747 FRDHNNEIVKIQSLLRANKARDDYKTLVGSENPPLTVIRKFVYLLDQSDLDFQEELEVAR 806
FR + E + +++ R + R D + S +PP + + L+ SD +E+L + R
Sbjct: 85 FRSSSKESL-VRTSSRESLNRLDLDSSTASFDPPSDMDSEAEDLVGNSDSLNKEQL-IQR 142
Query: 807 LREEVVTKIRANQQLEKDLNLMDIKIGLLVKNRITLEDVISHSKKLNKKKGGEMEILNNT 866
LR R+ + + +L + + L+ ++S S+ + ++ E+
Sbjct: 143 LRRME----RSLSSYRGKYSELVTAYQMLQREKKKLQGILSQSQDKSLRRIAELREELQM 198
Query: 867 DNQGIKSLSKERRKTLETYQQLFYLLQTNPLYLAKLIFQMPQN----------------- 909
D Q K L +E +LE Q +LQT L + + P N
Sbjct: 199 DQQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQRLRNGPMNVDVLKPLPQLEPQAEVF 258
Query: 910 ---------------------------KSTKFMDTVIFTLYNYASNQREEYLLLKLFKTA 942
+ K + ++ + +E+ LL K A
Sbjct: 259 TKEENPESDGEPVVEDGTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEA 318
Query: 943 LEEEIKSKVDQVQDIVTGNPTVIKMVVSFNRGARGQNTLRQLLAPVVKEIIDDKSLIINT 1002
L+E++ ++ +++ I + +++ R A+ +++++ DK ++I
Sbjct: 319 LQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKN----------LIEQLEQDKGMVIAE 368
Query: 1003 NPVEVYKAWVNQLETQTGEASKLPYDVTTEQALTYPEVKNKLEASIENLRRVTDKVLNSI 1062
++++ LE + E ++L + +Q T E +L E R + L
Sbjct: 369 TKRQMHET----LEMKEEEIAQLRSRI--KQMTTQGE---ELREQKEKSERAAFEELEKA 419
Query: 1063 ISSLDLLPYGLRYIAKVLKNSIHEKFPDATEDELLKIVGNLLYYRYMNPAIVAPDGFDII 1122
+S+ R + + I + +E+E + + L + V + D++
Sbjct: 420 LSTAQKTEEARRKLKAEMDEQI-KTIEKTSEEERISLQQEL--------SRVKQEVVDVM 470
Query: 1123 DMTAGGQINSDQRRNLGSVAKVLQHAASNKLFEGENEHLSSMNNYLSETYQEFRKYFKEA 1182
++ QI Q+ + +A+ Q + KL E E M L ++ E+ K +E
Sbjct: 471 KKSSEEQIAKLQKLHEKELARKEQEL-TKKLQTREREFQEQMKVALEKSQSEYLKISQEK 529
Query: 1183 CNVPEPEEKFNMDKYTDLVTVSKPVIYISIEEIISTHSLLLEHQDAIAPEKNDLLSELLG 1242
E +E +++ + + K I E + L + + +L S L
Sbjct: 530 ----EQQESLALEE----LELQKKAILTESENKLRD---LQQEAETYRTRILELESSLEK 578
Query: 1243 SLGEVPTVESFLGEGA-VDPNDPNKANTLS-QLSKTEISLVLTSKYDIEDGEAIDSRSLM 1300
SL E L + N NK T+ + KTE+ E++ +
Sbjct: 579 SLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTEL-------------ESLKHQQDA 625
Query: 1301 IKTKKLIIDVIRNQPGNTLTEILETPATAQQEVDHATDMVSRAMIDS---RTPEEMKHSQ 1357
+ T+KL V++ Q + ++ E ++ + +++ +A I+ +T E++ Q
Sbjct: 626 LWTEKL--QVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQ 683
Query: 1358 SMIEDAQLPLEQ---KKRKIQRNLRTL-EQTGHVSSE---------NKYQDILNEIAKD- 1403
+ +E L + + K++ L L +QT + E N +Q ++ I K+
Sbjct: 684 TELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEH 743
Query: 1404 -IRNQRIYRKLRKAELAKLQQTLNALNKKAAFYEEQINYYDTYIKTCLDNLKRKNTRRSI 1462
+ QR + L K ++ +L+ L +K ++ + + IK L++ S
Sbjct: 744 EVSIQRTEKAL-KDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQA----SA 798
Query: 1463 KLDGKGEPKGA--KRAKPVKYTAAKLHEKGVLLDIDDLQTNQFKNVTFDIIATEDVGIFD 1520
KLD + A ++ K + A+L +K LLD++ T I+ T+ V +
Sbjct: 799 KLDVFQSYQSATHEQTKAYEEQLAQLQQK--LLDLE----------TERILLTKQVAEVE 846
Query: 1521 VRSKFLGVEMEKVQLNIQDLLQ 1542
+ K + E++ ++ +QDL+Q
Sbjct: 847 AQKKDVCTELDAHKIQVQDLMQ 868
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.132 0.364
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 53,620,437
Number of Sequences: 37866
Number of extensions: 2303182
Number of successful extensions: 7020
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 21
Number of HSP's successfully gapped in prelim test: 170
Number of HSP's that attempted gapping in prelim test: 6571
Number of HSP's gapped (non-prelim): 584
length of query: 1575
length of database: 18,247,518
effective HSP length: 116
effective length of query: 1459
effective length of database: 13,855,062
effective search space: 20214535458
effective search space used: 20214535458
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.