Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 115583679
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|115583679 CCR4-NOT transcription complex, subunit 6-like
[Homo sapiens]
(555 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|115583679 CCR4-NOT transcription complex, subunit 6-like [Hom... 1137 0.0
gi|28872863 CCR4-NOT transcription complex, subunit 6 [Homo sapi... 895 0.0
gi|189027129 phosphodiesterase 12 [Homo sapiens] 136 6e-32
gi|224282153 angel homolog 1 [Homo sapiens] 114 2e-25
gi|36030946 LOC90806 protein [Homo sapiens] 105 1e-22
gi|31083028 CCR4 carbon catabolite repression 4-like [Homo sapiens] 94 3e-19
gi|153792305 leucine rich repeat containing 58 [Homo sapiens] 81 2e-15
gi|45827729 scribble isoform b [Homo sapiens] 78 2e-14
gi|45827731 scribble isoform a [Homo sapiens] 78 2e-14
gi|95113664 leucine rich repeat containing 1 [Homo sapiens] 73 8e-13
gi|61742786 leucine rich repeat and death domain containing prot... 72 1e-12
gi|61742784 leucine rich repeat and death domain containing prot... 72 1e-12
gi|61742782 leucine rich repeat and death domain containing prot... 72 1e-12
gi|55770895 ERBB2 interacting protein isoform 7 [Homo sapiens] 72 1e-12
gi|8923909 ERBB2 interacting protein isoform 2 [Homo sapiens] 72 1e-12
gi|6912638 ras suppressor protein 1 isoform 1 [Homo sapiens] 70 5e-12
gi|34577083 ras suppressor protein 1 isoform 2 [Homo sapiens] 70 5e-12
gi|21361633 leucine rich repeat containing 40 [Homo sapiens] 69 1e-11
gi|40254924 leucine rich repeat containing 59 [Homo sapiens] 68 2e-11
gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens] 67 4e-11
gi|157743290 leucine rich repeat containing 30 [Homo sapiens] 67 6e-11
gi|65301141 PH domain and leucine rich repeat protein phosphatas... 65 1e-10
gi|197333706 leucine rich repeat containing 8 family, member D [... 65 1e-10
gi|34222199 leucine rich repeat containing 8 family, member D [H... 65 1e-10
gi|53729363 leucine rich repeat and sterile alpha motif containi... 65 1e-10
gi|53729361 leucine rich repeat and sterile alpha motif containi... 65 1e-10
gi|53729359 leucine rich repeat and sterile alpha motif containi... 65 1e-10
gi|62241040 leucine rich repeat containing 8 family, member A [H... 65 2e-10
gi|187829877 leucine rich repeat containing 8 family, member A [... 65 2e-10
gi|187829871 leucine rich repeat containing 8 family, member A [... 65 2e-10
>gi|115583679 CCR4-NOT transcription complex, subunit 6-like [Homo
sapiens]
Length = 555
Score = 1137 bits (2940), Expect = 0.0
Identities = 555/555 (100%), Positives = 555/555 (100%)
Query: 1 MRLIGMPKEKYDPPDPRRIYTIMSAEEVANGKKSHWAELEISGRVRSLSTSLWSLTHLTA 60
MRLIGMPKEKYDPPDPRRIYTIMSAEEVANGKKSHWAELEISGRVRSLSTSLWSLTHLTA
Sbjct: 1 MRLIGMPKEKYDPPDPRRIYTIMSAEEVANGKKSHWAELEISGRVRSLSTSLWSLTHLTA 60
Query: 61 LHLNDNYLSRIPPDIAKLHNLVYLDLSSNKLRSLPAELGNMVSLRELLLNNNLLRVLPYE 120
LHLNDNYLSRIPPDIAKLHNLVYLDLSSNKLRSLPAELGNMVSLRELLLNNNLLRVLPYE
Sbjct: 61 LHLNDNYLSRIPPDIAKLHNLVYLDLSSNKLRSLPAELGNMVSLRELLLNNNLLRVLPYE 120
Query: 121 LGRLFQLQTLGLKGNPLSQDILNLYQDPDGTRKLLNFMLDNLAVHPEQLPPRPWITLKER 180
LGRLFQLQTLGLKGNPLSQDILNLYQDPDGTRKLLNFMLDNLAVHPEQLPPRPWITLKER
Sbjct: 121 LGRLFQLQTLGLKGNPLSQDILNLYQDPDGTRKLLNFMLDNLAVHPEQLPPRPWITLKER 180
Query: 181 DQILPSASFTVMCYNVLCDKYATRQLYGYCPSWALNWEYRKKGIMEEIVNCDADIISLQE 240
DQILPSASFTVMCYNVLCDKYATRQLYGYCPSWALNWEYRKKGIMEEIVNCDADIISLQE
Sbjct: 181 DQILPSASFTVMCYNVLCDKYATRQLYGYCPSWALNWEYRKKGIMEEIVNCDADIISLQE 240
Query: 241 VETEQYFTLFLPALKERGYDGFFSPKSRAKIMSEQERKHVDGCAIFFKTEKFTLVQKHTV 300
VETEQYFTLFLPALKERGYDGFFSPKSRAKIMSEQERKHVDGCAIFFKTEKFTLVQKHTV
Sbjct: 241 VETEQYFTLFLPALKERGYDGFFSPKSRAKIMSEQERKHVDGCAIFFKTEKFTLVQKHTV 300
Query: 301 EFNQVAMANSDGSEAMLNRVMTKDNIGVAVVLEVHKELFGAGMKPIHAADKQLLIVANAH 360
EFNQVAMANSDGSEAMLNRVMTKDNIGVAVVLEVHKELFGAGMKPIHAADKQLLIVANAH
Sbjct: 301 EFNQVAMANSDGSEAMLNRVMTKDNIGVAVVLEVHKELFGAGMKPIHAADKQLLIVANAH 360
Query: 361 MHWDPEYSDVKLIQTMMFVSEVKNILEKASSRPGSPTADPNSIPLVLCADLNSLPDSGVV 420
MHWDPEYSDVKLIQTMMFVSEVKNILEKASSRPGSPTADPNSIPLVLCADLNSLPDSGVV
Sbjct: 361 MHWDPEYSDVKLIQTMMFVSEVKNILEKASSRPGSPTADPNSIPLVLCADLNSLPDSGVV 420
Query: 421 EYLSNGGVADNHKDFKELRYNECLMNFSCNGKNGSSEGRITHGFQLKSAYENNLMPYTNY 480
EYLSNGGVADNHKDFKELRYNECLMNFSCNGKNGSSEGRITHGFQLKSAYENNLMPYTNY
Sbjct: 421 EYLSNGGVADNHKDFKELRYNECLMNFSCNGKNGSSEGRITHGFQLKSAYENNLMPYTNY 480
Query: 481 TFDFKGVIDYIFYSKTHMNVLGVLGPLDPQWLVENNITGCPHPHIPSDHFSLLTQLELHP 540
TFDFKGVIDYIFYSKTHMNVLGVLGPLDPQWLVENNITGCPHPHIPSDHFSLLTQLELHP
Sbjct: 481 TFDFKGVIDYIFYSKTHMNVLGVLGPLDPQWLVENNITGCPHPHIPSDHFSLLTQLELHP 540
Query: 541 PLLPLVNGVHLPNRR 555
PLLPLVNGVHLPNRR
Sbjct: 541 PLLPLVNGVHLPNRR 555
>gi|28872863 CCR4-NOT transcription complex, subunit 6 [Homo
sapiens]
Length = 557
Score = 895 bits (2312), Expect = 0.0
Identities = 437/557 (78%), Positives = 493/557 (88%), Gaps = 7/557 (1%)
Query: 6 MPKEKYDPPDPRRIYTIMSAEEVANGKKSHWAELEISGRVRSLSTSLWSLTHLTALHLND 65
MPKEKY+PPDPRR+YTIMS+EE ANGKKSHWAELEISG+VRSLS SLWSLTHLTALHL+D
Sbjct: 1 MPKEKYEPPDPRRMYTIMSSEEAANGKKSHWAELEISGKVRSLSASLWSLTHLTALHLSD 60
Query: 66 NYLSRIPPDIAKLHNLVYLDLSSNKLRSLPAELGNMVSLRELLLNNNLLRVLPYELGRLF 125
N LSRIP DIAKLHNLVYLDLSSNK+RSLPAELGNMVSLREL LNNNLLRVLP+ELG+LF
Sbjct: 61 NSLSRIPSDIAKLHNLVYLDLSSNKIRSLPAELGNMVSLRELHLNNNLLRVLPFELGKLF 120
Query: 126 QLQTLGLKGNPLSQDILNLYQDPDGTRKLLNFMLDNLA-----VHPEQLPPRPWITLKER 180
QLQTLGLKGNPL+QDILNLYQ+PDGTR+LLN++LDNL+ + EQ PPR WI L+E
Sbjct: 121 QLQTLGLKGNPLTQDILNLYQEPDGTRRLLNYLLDNLSGTAKRITTEQPPPRSWIMLQEP 180
Query: 181 DQILPSASFTVMCYNVLCDKYATRQLYGYCPSWALNWEYRKKGIMEEIVNCDADIISLQE 240
D+ P+A F+VMCYNVLCDKYATRQLYGYCPSWALNW+YRKK I++EI++C+ADI+SLQE
Sbjct: 181 DRTRPTALFSVMCYNVLCDKYATRQLYGYCPSWALNWDYRKKAIIQEILSCNADIVSLQE 240
Query: 241 VETEQYFTLFLPALKERGYDGFFSPKSRAKIMSEQERKHVDGCAIFFKTEKFTLVQKHTV 300
VETEQY++ FL LKERGY+GFFSPKSRA+ MSEQERKHVDGCAIFFKTEKFTLVQKHTV
Sbjct: 241 VETEQYYSFFLVELKERGYNGFFSPKSRARTMSEQERKHVDGCAIFFKTEKFTLVQKHTV 300
Query: 301 EFNQVAMANSDGSEAMLNRVMTKDNIGVAVVLEVHKE-LFGAGMKPIHAADKQLLIVANA 359
EFNQ+AMANS+GSEAMLNRVMTKDNIGVAV+LE+ KE + KP +KQL++VANA
Sbjct: 301 EFNQLAMANSEGSEAMLNRVMTKDNIGVAVLLELRKESIEMPSGKPHLGTEKQLILVANA 360
Query: 360 HMHWDPEYSDVKLIQTMMFVSEVKNILEKAS-SRPGSPTADPNSIPLVLCADLNSLPDSG 418
HMHWDPEYSDVKL+QTMMF+SEVKNI++KAS + S + +IPLVLCADLNSLPDSG
Sbjct: 361 HMHWDPEYSDVKLVQTMMFLSEVKNIIDKASRNLKSSVLGEFGTIPLVLCADLNSLPDSG 420
Query: 419 VVEYLSNGGVADNHKDFKELRYNECLMNFSCNGKNGSSEGRITHGFQLKSAYENNLMPYT 478
VVEYLS GGV NHKDFKELRYNE L NFSC+GKNG++ GRITHGF+L+SAYE+ LMPYT
Sbjct: 421 VVEYLSTGGVETNHKDFKELRYNESLTNFSCHGKNGTTNGRITHGFKLQSAYESGLMPYT 480
Query: 479 NYTFDFKGVIDYIFYSKTHMNVLGVLGPLDPQWLVENNITGCPHPHIPSDHFSLLTQLEL 538
NYTFDFKG+IDYIFYSK +N LG+LGPLD WLVENNI+GCPHP IPSDHFSL QLEL
Sbjct: 481 NYTFDFKGIIDYIFYSKPQLNTLGILGPLDHHWLVENNISGCPHPLIPSDHFSLFAQLEL 540
Query: 539 HPPLLPLVNGVHLPNRR 555
P LP VNG+HLP RR
Sbjct: 541 LLPFLPQVNGIHLPGRR 557
>gi|189027129 phosphodiesterase 12 [Homo sapiens]
Length = 609
Score = 136 bits (342), Expect = 6e-32
Identities = 99/361 (27%), Positives = 169/361 (46%), Gaps = 46/361 (12%)
Query: 182 QILPSASFTVMCYNVLCDKYATRQ-----LYGYCPSWALNWEYRKKGIMEEIVNCDADII 236
++ A + YN+L D YA + LY YC +AL +YR+ I +E+ +AD+I
Sbjct: 288 KVTEDALIRTVSYNILADTYAQTEFSRTVLYPYCAPYALELDYRQNLIQKELTGYNADVI 347
Query: 237 SLQEVETEQYFTLFLPALKERGYDGFFSPKSRAKIMSEQERKHVDGCAIFFKTEKFTLVQ 296
LQEV+ + +PAL+ G +G F K +G A F++ KF+L+
Sbjct: 348 CLQEVDRAVFSDSLVPALEAFGLEGVFRIKQH------------EGLATFYRKSKFSLLS 395
Query: 297 KHTVEFNQVAMANSDGSEAMLNRVMTKDNIGVAVVLEVHKELFGAGMKPIHAADKQLLIV 356
+H + F + ++ E + V+ VL+ L + ++ + K+ + V
Sbjct: 396 QHDISFYEALESDPLHKELLEKLVLYPS--AQEKVLQRSSVLQVSVLQSTKDSSKR-ICV 452
Query: 357 ANAHMHWDPEYSDVKLIQTMMFVSEVKNILEKASSRPGSPTADPNSIPLVLCADLNSLPD 416
AN H++W P+ ++LIQ + ++ ++++ PG IP++ C D NS P
Sbjct: 453 ANTHLYWHPKGGYIRLIQMAVALAHIRHV--SCDLYPG--------IPVIFCGDFNSTPS 502
Query: 417 SGVVEYLSNGGVADNHKDFKELRYNECLMNFSCNGKNGSSEGRITHGFQLKSAYENNLMP 476
+G+ ++ NG + ++H+D ++ NG+ +TH F+LKSA
Sbjct: 503 TGMYHFVINGSIPEDHED------------WASNGEEERCNMSLTHFFKLKSACGE--PA 548
Query: 477 YTNYTFDFKGVIDYIFYSKTHMNVLGVLGPLDPQWLVENNITGCPHPHIPSDHFSLLTQL 536
YTNY F G +DYIF + V V+ PL V + P PSDH +L+ L
Sbjct: 549 YTNYVGGFHGCLDYIFIDLNALEVEQVI-PLPSHEEVTTH-QALPSVSHPSDHIALVCDL 606
Query: 537 E 537
+
Sbjct: 607 K 607
>gi|224282153 angel homolog 1 [Homo sapiens]
Length = 670
Score = 114 bits (286), Expect = 2e-25
Identities = 71/244 (29%), Positives = 123/244 (50%), Gaps = 37/244 (15%)
Query: 185 PSASFTVMCYNVLCDKYATR--QLYGYCPSWALNWEYRKKGIMEEIVNCDADIISLQEVE 242
P FT+M YN+L + +LY +C LNW YR +M+E + D DI+ LQEV+
Sbjct: 241 PQFQFTLMSYNILAQDLMQQSSELYLHCHPDILNWNYRFVNLMQEFQHWDPDILCLQEVQ 300
Query: 243 TEQYFTLFLPALKERGYDGFFSPKSRAKIMSEQERKHVDGCAIFFKTEKFTLVQKHTVEF 302
+ Y+ P+L+ G+ F+ ++ K DGCA+ +K +F L+ VE+
Sbjct: 301 EDHYWEQLEPSLRMMGFTCFYKRRTGCK---------TDGCAVCYKPTRFRLLCASPVEY 351
Query: 303 NQVAMANSDGSEAMLNRVMTKDNIGVAVVLEVHKELFGAGMKPIHAADKQLLIVANAHMH 362
+ + ++ +DN+G+ ++L+ L G+ + A L VAN H+
Sbjct: 352 FRPGL-----------ELLNRDNVGLVLLLQ---PLVPEGLGQVSVAP---LCVANTHIL 394
Query: 363 WDPEYSDVKLIQTMMFVSEVKNILEKASSRPGSPTADPNSIPLVLCADLNSLPDSGVVEY 422
++P DVKL Q + ++EV + + +D + P++LC DLNS+PDS + +
Sbjct: 395 YNPRRGDVKLAQMAILLAEVDKV---------ARLSDGSHCPIILCGDLNSVPDSPLYNF 445
Query: 423 LSNG 426
+ +G
Sbjct: 446 IRDG 449
>gi|36030946 LOC90806 protein [Homo sapiens]
Length = 544
Score = 105 bits (262), Expect = 1e-22
Identities = 68/240 (28%), Positives = 117/240 (48%), Gaps = 41/240 (17%)
Query: 189 FTVMCYNVLCDKYA--TRQLYGYCPSWALNWEYRKKGIMEEIVNCDADIISLQEVETEQY 246
F+VM YN+L LY +C L+W +R I++EI + DAD++ LQEV+ + Y
Sbjct: 167 FSVMSYNILSQDLLEDNSHLYRHCRRPVLHWSFRFPNILKEIKHFDADVLCLQEVQEDHY 226
Query: 247 FTLFLPALKERGYDGFFSPKSRAKIMSEQERKHVDGCAIFFKTEKFTLVQKHTVEFNQVA 306
P+L+ GY + ++ K DGCAI FK KF+L+ + VEF +
Sbjct: 227 GAEIRPSLESLGYHCEYKMRTGRK---------PDGCAICFKHSKFSLLSVNPVEFFRPD 277
Query: 307 MANSDGSEAMLNRVMTKDNIGVAVVLEVHKELFGAGMKPIHAADKQLLIVANAHMHWDPE 366
++ ++ +DN+G+ ++L+ I A + VAN H+ ++P
Sbjct: 278 IS-----------LLDRDNVGLVLLLQ----------PKIPYAACPAICVANTHLLYNPR 316
Query: 367 YSDVKLIQTMMFVSEVKNILEKASSRPGSPTADPNSIPLVLCADLNSLPDSGVVEYLSNG 426
D+KL Q M ++E+ ++ + D + P+V+C D NS+P S + ++ G
Sbjct: 317 RGDIKLTQLAMLLAEISSVAHQ---------KDGSFCPIVMCGDFNSVPGSPLYSFIKEG 367
>gi|31083028 CCR4 carbon catabolite repression 4-like [Homo sapiens]
Length = 431
Score = 94.0 bits (232), Expect = 3e-19
Identities = 86/348 (24%), Positives = 134/348 (38%), Gaps = 79/348 (22%)
Query: 191 VMCYNVLCDKYAT-RQLYGYCPSWALNWEYRKKGIMEEIVNCDADIISLQEVETEQYFTL 249
VM +N+L + + CP AL WE RK I+EEI+ DI+ LQEV+ YF
Sbjct: 145 VMQWNILAQALGEGKDNFVQCPVEALKWEERKCLILEEILAYQPDILCLQEVD--HYFDT 202
Query: 250 FLPALKERGYDGFFSPKSRAKIMSEQERKHVDGCAIFFKTEKFTLVQKHTVEFNQVAMAN 309
F P L GY G F PK + + + DGCA+FF +F LV + + +
Sbjct: 203 FQPLLSRLGYQGTFFPKPWSPCLDVEHNNGPDGCALFFLQNRFKLVNSANIRLTAMTLKT 262
Query: 310 SDGSEAMLNRVMTKDNIGVAVVLEVHKELFGAGMKPIHAADKQLLIVANAHMHWDPEYSD 369
+ + +A LE + + +A H+ +
Sbjct: 263 --------------NQVAIAQTLECKE-------------SGRQFCIAVTHLKARTGWER 295
Query: 370 VKLIQTMMFVSEVKNILEKASSRPGSPTADPNSIPLVLCADLNSLPDSGVVEYLSNGGVA 429
+ Q + ++NI + A IPL++C D N+ P V ++ +
Sbjct: 296 FRSAQGCDLLQNLQNITQGA------------KIPLIVCGDFNAEPTEEVYKHFA----- 338
Query: 430 DNHKDFKELRYNECLMNFSCNGKNGSSEGRITHGFQLKSAYENNLMPYTNYTFDFKG--- 486
SS + ++L SA + PYT + G
Sbjct: 339 -------------------------SSSLNLNSAYKLLSADGQSEPPYTTWKIRTSGECR 373
Query: 487 -VIDYIFYSKTHMNVLGVLGPLDPQWLVENNITGCPHPHIPSDHFSLL 533
+DYI+YSK +NV L L + + N + P + PSDH SL+
Sbjct: 374 HTLDYIWYSKHALNVRSALDLLTEEQIGPNRL---PSFNYPSDHLSLV 418
>gi|153792305 leucine rich repeat containing 58 [Homo sapiens]
Length = 371
Score = 81.3 bits (199), Expect = 2e-15
Identities = 47/130 (36%), Positives = 75/130 (57%), Gaps = 3/130 (2%)
Query: 44 RVRSLSTSLWSLTHLTALHLNDNYLSRIPPDIAKLHNLVYLDLSSNKLRSLPAELGNMVS 103
+++S+ + +L L L+L N++ IPP++ L +L YL L NK++S+P +L + S
Sbjct: 154 QLQSIPAEIENLQSLECLYLGGNFIKEIPPELGNLPSLNYLVLCDNKIQSIPPQLSQLHS 213
Query: 104 LRELLLNNNLLRVLPYELGRLFQLQTLGLKGNPL-SQDILNLYQDPDGTRKLL--NFMLD 160
LR L L+NNLL LP E+ L L+ L L+GNPL + + +L DP +L +
Sbjct: 214 LRSLSLHNNLLTYLPREILNLIHLEELSLRGNPLVVRFVRDLTYDPPTLLELAARTIKIR 273
Query: 161 NLAVHPEQLP 170
N++ P LP
Sbjct: 274 NISYTPYDLP 283
Score = 53.5 bits (127), Expect = 5e-07
Identities = 30/80 (37%), Positives = 44/80 (55%)
Query: 58 LTALHLNDNYLSRIPPDIAKLHNLVYLDLSSNKLRSLPAELGNMVSLRELLLNNNLLRVL 117
L L+L+ N +P + +L L L L N+L+S+PAE+ N+ SL L L N ++ +
Sbjct: 122 LQVLNLSGNCFQEVPASLLELRALQTLSLGGNQLQSIPAEIENLQSLECLYLGGNFIKEI 181
Query: 118 PYELGRLFQLQTLGLKGNPL 137
P ELG L L L L N +
Sbjct: 182 PPELGNLPSLNYLVLCDNKI 201
Score = 38.5 bits (88), Expect = 0.016
Identities = 35/101 (34%), Positives = 50/101 (49%), Gaps = 7/101 (6%)
Query: 44 RVRSLSTSLWS-LTHLTALHLNDNYLSRIPPDIAKLHNLVYLDLSSNKL---RSLPAELG 99
R+ SL +L S HL L ++ N L+ + P++ L L L +N+L +LP L
Sbjct: 55 RLVSLPRALGSGFPHLQLLDVSGNALTALGPELLALRGLRTLLAKNNRLGGPSALPKGLA 114
Query: 100 NMV---SLRELLLNNNLLRVLPYELGRLFQLQTLGLKGNPL 137
SL+ L L+ N + +P L L LQTL L GN L
Sbjct: 115 QSPLCRSLQVLNLSGNCFQEVPASLLELRALQTLSLGGNQL 155
Score = 30.8 bits (68), Expect = 3.4
Identities = 31/85 (36%), Positives = 38/85 (44%), Gaps = 7/85 (8%)
Query: 58 LTALHLNDNYLSRIPPDIAK-LHNLVYLDLSSNKLRSLPAELGNMVSLRELLLNNNLL-- 114
L L L N L +P + +L LD+S N L +L EL + LR LL NN L
Sbjct: 46 LLRLLLPHNRLVSLPRALGSGFPHLQLLDVSGNALTALGPELLALRGLRTLLAKNNRLGG 105
Query: 115 -RVLPYELGR---LFQLQTLGLKGN 135
LP L + LQ L L GN
Sbjct: 106 PSALPKGLAQSPLCRSLQVLNLSGN 130
>gi|45827729 scribble isoform b [Homo sapiens]
Length = 1630
Score = 77.8 bits (190), Expect = 2e-14
Identities = 45/103 (43%), Positives = 65/103 (63%), Gaps = 1/103 (0%)
Query: 38 ELEISGR-VRSLSTSLWSLTHLTALHLNDNYLSRIPPDIAKLHNLVYLDLSSNKLRSLPA 96
+L++ G + L +L +L +L L L+ N LS +PP++ L LV LD+S N+L LPA
Sbjct: 178 QLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPA 237
Query: 97 ELGNMVSLRELLLNNNLLRVLPYELGRLFQLQTLGLKGNPLSQ 139
ELG +V L +LLL+ NLLR LP +G+L QL L + N L +
Sbjct: 238 ELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCE 280
Score = 65.1 bits (157), Expect = 2e-10
Identities = 43/89 (48%), Positives = 50/89 (56%), Gaps = 3/89 (3%)
Query: 50 TSLWSLTHLTALHLNDNYLSRIPPDIAKLHNLVYLDLSSNKLRSLPAELGNMVSLRELLL 109
T L SL HL LND L +P D+ L NLV L+L N L+SLPA L +V L +L L
Sbjct: 125 TQLRSLAHLA---LNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDL 181
Query: 110 NNNLLRVLPYELGRLFQLQTLGLKGNPLS 138
N L VLP LG L L+ L L N LS
Sbjct: 182 GGNDLEVLPDTLGALPNLRELWLDRNQLS 210
Score = 60.8 bits (146), Expect = 3e-09
Identities = 39/106 (36%), Positives = 58/106 (54%), Gaps = 2/106 (1%)
Query: 34 SHWAELEISGRVRSLSTSLWSLTHLTALHLNDNYLSRIPPDIAKLHNLVYLDLSSNKLRS 93
+H A ++S +++L + +L +L L L +N L +P ++ L L LDL N L
Sbjct: 131 AHLALNDVS--LQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEV 188
Query: 94 LPAELGNMVSLRELLLNNNLLRVLPYELGRLFQLQTLGLKGNPLSQ 139
LP LG + +LREL L+ N L LP ELG L +L L + N L +
Sbjct: 189 LPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEE 234
Score = 58.9 bits (141), Expect = 1e-08
Identities = 37/100 (37%), Positives = 53/100 (53%), Gaps = 1/100 (1%)
Query: 39 LEIS-GRVRSLSTSLWSLTHLTALHLNDNYLSRIPPDIAKLHNLVYLDLSSNKLRSLPAE 97
L++S R+ L L L LT L L+ N L R+P I +L L L + N+L +
Sbjct: 225 LDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEA 284
Query: 98 LGNMVSLRELLLNNNLLRVLPYELGRLFQLQTLGLKGNPL 137
+G+ +L EL+L NLL LP LG+L +L L + N L
Sbjct: 285 IGDCENLSELILTENLLMALPRSLGKLTKLTNLNVDRNHL 324
Score = 58.9 bits (141), Expect = 1e-08
Identities = 43/153 (28%), Positives = 75/153 (49%), Gaps = 14/153 (9%)
Query: 44 RVRSLSTSLWSLTHLTALHLNDNYLSRIPPDIAKLHNLVYLDLSSNKLRSLPAELGNMVS 103
R+ ++ ++ +L+ L L +N L +P + KL L L++ N L +LP E+G V+
Sbjct: 277 RLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVA 336
Query: 104 LRELLLNNNLLRVLPYELGRLFQLQTLGLKGNPLSQ--------DILNLYQDPDGTRKLL 155
L L L +N L VLP EL +L L + GN L ++ L+ + + +L
Sbjct: 337 LSVLSLRDNRLAVLPPELAHTTELHVLDVAGNRLQSLPFALTHLNLKALWLAENQAQPML 396
Query: 156 NFMLDNLAVHPEQ------LPPRPWITLKERDQ 182
F ++ A E+ LP +P ++L++ Q
Sbjct: 397 RFQTEDDARTGEKVLTCYLLPQQPPLSLEDAGQ 429
Score = 56.6 bits (135), Expect = 6e-08
Identities = 39/112 (34%), Positives = 60/112 (53%), Gaps = 3/112 (2%)
Query: 27 EVANGKKSHWAELEISGR-VRSLSTSLWSLTHLTALHLNDNYLSRIPPDIAKLHNLVYLD 85
EVAN + EL++S + + S+ L + N LSR+P +L +L +L
Sbjct: 77 EVANFMQL--VELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLA 134
Query: 86 LSSNKLRSLPAELGNMVSLRELLLNNNLLRVLPYELGRLFQLQTLGLKGNPL 137
L+ L++LP ++GN+ +L L L NLL+ LP L L +L+ L L GN L
Sbjct: 135 LNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDL 186
Score = 55.1 bits (131), Expect = 2e-07
Identities = 44/114 (38%), Positives = 57/114 (50%), Gaps = 5/114 (4%)
Query: 45 VRSLSTSLWSLTHLTALHLNDNYLSRIPPDIAKLHNLVYLDLSSNKLRSLPAELGNMVSL 104
++SL SL L L L L N L +P + L NL L L N+L +LP ELGN+ L
Sbjct: 163 LKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRL 222
Query: 105 RELLLNNNLLRVLPYELGRLFQLQTLGLKGNPLSQDILNLYQDPDGTRKLLNFM 158
L ++ N L LP ELG L L L LSQ++L D G K L+ +
Sbjct: 223 VCLDVSENRLEELPAELGGLVLLTDL-----LLSQNLLRRLPDGIGQLKQLSIL 271
Score = 50.8 bits (120), Expect = 3e-06
Identities = 31/94 (32%), Positives = 45/94 (47%)
Query: 45 VRSLSTSLWSLTHLTALHLNDNYLSRIPPDIAKLHNLVYLDLSSNKLRSLPAELGNMVSL 104
+R L + L L+ L ++ N L + I NL L L+ N L +LP LG + L
Sbjct: 255 LRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTKL 314
Query: 105 RELLLNNNLLRVLPYELGRLFQLQTLGLKGNPLS 138
L ++ N L LP E+G L L L+ N L+
Sbjct: 315 TNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLA 348
Score = 48.9 bits (115), Expect = 1e-05
Identities = 42/137 (30%), Positives = 66/137 (48%), Gaps = 17/137 (12%)
Query: 58 LTALHLNDNYLSRIPPDIAKLHNLVYLDLSSNKLRSLPAELGNMVSLRELLLNNNLLRVL 117
L L L+ N L +P +L NL L LS N+++ LP E+ N + L EL ++ N + +
Sbjct: 38 LEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPEI 97
Query: 118 PYELGRLFQLQTLGLKGNPLSQDILNLYQDPDGTRKLLNFMLDNLAVHPEQLPPRP---- 173
P + L+ GNPLS + PDG +L + L +LA++ L P
Sbjct: 98 PESIKFCKALEIADFSGNPLS-------RLPDGFTQLRS--LAHLALNDVSLQALPGDVG 148
Query: 174 ----WITLKERDQILPS 186
+TL+ R+ +L S
Sbjct: 149 NLANLVTLELRENLLKS 165
Score = 38.5 bits (88), Expect = 0.016
Identities = 26/90 (28%), Positives = 47/90 (52%), Gaps = 2/90 (2%)
Query: 52 LWSLT-HLTALHLNDNYLSRIPPDIAKL-HNLVYLDLSSNKLRSLPAELGNMVSLRELLL 109
LW H+ ++ L +P +I + +L L L +N+LR LP +++LR+L L
Sbjct: 7 LWRCNRHVESVDKRHCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGL 66
Query: 110 NNNLLRVLPYELGRLFQLQTLGLKGNPLSQ 139
++N ++ LP E+ QL L + N + +
Sbjct: 67 SDNEIQRLPPEVANFMQLVELDVSRNDIPE 96
>gi|45827731 scribble isoform a [Homo sapiens]
Length = 1655
Score = 77.8 bits (190), Expect = 2e-14
Identities = 45/103 (43%), Positives = 65/103 (63%), Gaps = 1/103 (0%)
Query: 38 ELEISGR-VRSLSTSLWSLTHLTALHLNDNYLSRIPPDIAKLHNLVYLDLSSNKLRSLPA 96
+L++ G + L +L +L +L L L+ N LS +PP++ L LV LD+S N+L LPA
Sbjct: 178 QLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPA 237
Query: 97 ELGNMVSLRELLLNNNLLRVLPYELGRLFQLQTLGLKGNPLSQ 139
ELG +V L +LLL+ NLLR LP +G+L QL L + N L +
Sbjct: 238 ELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCE 280
Score = 65.1 bits (157), Expect = 2e-10
Identities = 43/89 (48%), Positives = 50/89 (56%), Gaps = 3/89 (3%)
Query: 50 TSLWSLTHLTALHLNDNYLSRIPPDIAKLHNLVYLDLSSNKLRSLPAELGNMVSLRELLL 109
T L SL HL LND L +P D+ L NLV L+L N L+SLPA L +V L +L L
Sbjct: 125 TQLRSLAHLA---LNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDL 181
Query: 110 NNNLLRVLPYELGRLFQLQTLGLKGNPLS 138
N L VLP LG L L+ L L N LS
Sbjct: 182 GGNDLEVLPDTLGALPNLRELWLDRNQLS 210
Score = 60.8 bits (146), Expect = 3e-09
Identities = 39/106 (36%), Positives = 58/106 (54%), Gaps = 2/106 (1%)
Query: 34 SHWAELEISGRVRSLSTSLWSLTHLTALHLNDNYLSRIPPDIAKLHNLVYLDLSSNKLRS 93
+H A ++S +++L + +L +L L L +N L +P ++ L L LDL N L
Sbjct: 131 AHLALNDVS--LQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEV 188
Query: 94 LPAELGNMVSLRELLLNNNLLRVLPYELGRLFQLQTLGLKGNPLSQ 139
LP LG + +LREL L+ N L LP ELG L +L L + N L +
Sbjct: 189 LPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEE 234
Score = 58.9 bits (141), Expect = 1e-08
Identities = 37/100 (37%), Positives = 53/100 (53%), Gaps = 1/100 (1%)
Query: 39 LEIS-GRVRSLSTSLWSLTHLTALHLNDNYLSRIPPDIAKLHNLVYLDLSSNKLRSLPAE 97
L++S R+ L L L LT L L+ N L R+P I +L L L + N+L +
Sbjct: 225 LDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEA 284
Query: 98 LGNMVSLRELLLNNNLLRVLPYELGRLFQLQTLGLKGNPL 137
+G+ +L EL+L NLL LP LG+L +L L + N L
Sbjct: 285 IGDCENLSELILTENLLMALPRSLGKLTKLTNLNVDRNHL 324
Score = 58.9 bits (141), Expect = 1e-08
Identities = 43/153 (28%), Positives = 75/153 (49%), Gaps = 14/153 (9%)
Query: 44 RVRSLSTSLWSLTHLTALHLNDNYLSRIPPDIAKLHNLVYLDLSSNKLRSLPAELGNMVS 103
R+ ++ ++ +L+ L L +N L +P + KL L L++ N L +LP E+G V+
Sbjct: 277 RLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVA 336
Query: 104 LRELLLNNNLLRVLPYELGRLFQLQTLGLKGNPLSQ--------DILNLYQDPDGTRKLL 155
L L L +N L VLP EL +L L + GN L ++ L+ + + +L
Sbjct: 337 LSVLSLRDNRLAVLPPELAHTTELHVLDVAGNRLQSLPFALTHLNLKALWLAENQAQPML 396
Query: 156 NFMLDNLAVHPEQ------LPPRPWITLKERDQ 182
F ++ A E+ LP +P ++L++ Q
Sbjct: 397 RFQTEDDARTGEKVLTCYLLPQQPPLSLEDAGQ 429
Score = 56.6 bits (135), Expect = 6e-08
Identities = 39/112 (34%), Positives = 60/112 (53%), Gaps = 3/112 (2%)
Query: 27 EVANGKKSHWAELEISGR-VRSLSTSLWSLTHLTALHLNDNYLSRIPPDIAKLHNLVYLD 85
EVAN + EL++S + + S+ L + N LSR+P +L +L +L
Sbjct: 77 EVANFMQL--VELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLA 134
Query: 86 LSSNKLRSLPAELGNMVSLRELLLNNNLLRVLPYELGRLFQLQTLGLKGNPL 137
L+ L++LP ++GN+ +L L L NLL+ LP L L +L+ L L GN L
Sbjct: 135 LNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDL 186
Score = 55.1 bits (131), Expect = 2e-07
Identities = 44/114 (38%), Positives = 57/114 (50%), Gaps = 5/114 (4%)
Query: 45 VRSLSTSLWSLTHLTALHLNDNYLSRIPPDIAKLHNLVYLDLSSNKLRSLPAELGNMVSL 104
++SL SL L L L L N L +P + L NL L L N+L +LP ELGN+ L
Sbjct: 163 LKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRL 222
Query: 105 RELLLNNNLLRVLPYELGRLFQLQTLGLKGNPLSQDILNLYQDPDGTRKLLNFM 158
L ++ N L LP ELG L L L LSQ++L D G K L+ +
Sbjct: 223 VCLDVSENRLEELPAELGGLVLLTDL-----LLSQNLLRRLPDGIGQLKQLSIL 271
Score = 50.8 bits (120), Expect = 3e-06
Identities = 31/94 (32%), Positives = 45/94 (47%)
Query: 45 VRSLSTSLWSLTHLTALHLNDNYLSRIPPDIAKLHNLVYLDLSSNKLRSLPAELGNMVSL 104
+R L + L L+ L ++ N L + I NL L L+ N L +LP LG + L
Sbjct: 255 LRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTKL 314
Query: 105 RELLLNNNLLRVLPYELGRLFQLQTLGLKGNPLS 138
L ++ N L LP E+G L L L+ N L+
Sbjct: 315 TNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLA 348
Score = 48.9 bits (115), Expect = 1e-05
Identities = 42/137 (30%), Positives = 66/137 (48%), Gaps = 17/137 (12%)
Query: 58 LTALHLNDNYLSRIPPDIAKLHNLVYLDLSSNKLRSLPAELGNMVSLRELLLNNNLLRVL 117
L L L+ N L +P +L NL L LS N+++ LP E+ N + L EL ++ N + +
Sbjct: 38 LEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPEI 97
Query: 118 PYELGRLFQLQTLGLKGNPLSQDILNLYQDPDGTRKLLNFMLDNLAVHPEQLPPRP---- 173
P + L+ GNPLS + PDG +L + L +LA++ L P
Sbjct: 98 PESIKFCKALEIADFSGNPLS-------RLPDGFTQLRS--LAHLALNDVSLQALPGDVG 148
Query: 174 ----WITLKERDQILPS 186
+TL+ R+ +L S
Sbjct: 149 NLANLVTLELRENLLKS 165
Score = 38.5 bits (88), Expect = 0.016
Identities = 26/90 (28%), Positives = 47/90 (52%), Gaps = 2/90 (2%)
Query: 52 LWSLT-HLTALHLNDNYLSRIPPDIAKL-HNLVYLDLSSNKLRSLPAELGNMVSLRELLL 109
LW H+ ++ L +P +I + +L L L +N+LR LP +++LR+L L
Sbjct: 7 LWRCNRHVESVDKRHCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGL 66
Query: 110 NNNLLRVLPYELGRLFQLQTLGLKGNPLSQ 139
++N ++ LP E+ QL L + N + +
Sbjct: 67 SDNEIQRLPPEVANFMQLVELDVSRNDIPE 96
>gi|95113664 leucine rich repeat containing 1 [Homo sapiens]
Length = 524
Score = 72.8 bits (177), Expect = 8e-13
Identities = 39/103 (37%), Positives = 64/103 (62%), Gaps = 1/103 (0%)
Query: 38 ELEI-SGRVRSLSTSLWSLTHLTALHLNDNYLSRIPPDIAKLHNLVYLDLSSNKLRSLPA 96
EL++ + + +L S+ +L HL L L+ N LS +P +I L NL+ LD+S N+L LP
Sbjct: 178 ELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEIGNLKNLLCLDVSENRLERLPE 237
Query: 97 ELGNMVSLRELLLNNNLLRVLPYELGRLFQLQTLGLKGNPLSQ 139
E+ + SL +L+++ NLL +P +G+L +L L + N L+Q
Sbjct: 238 EISGLTSLTDLVISQNLLETIPDGIGKLKKLSILKVDQNRLTQ 280
Score = 62.0 bits (149), Expect = 1e-09
Identities = 42/100 (42%), Positives = 53/100 (53%), Gaps = 3/100 (3%)
Query: 48 LSTSLWSLTHLTALHLNDNYLSRIPPDIAKLHNLVYLDLSSNKLRSLPAELGNMVSLREL 107
L S L +LT L +ND L +P +I L+NL L+L N L LP L + L EL
Sbjct: 120 LPESFPELQNLTCLSVNDISLQSLPENIGNLYNLASLELRENLLTYLPDSLTQLRRLEEL 179
Query: 108 LLNNNLLRVLPYELGRLFQLQTLGLKGNPLS---QDILNL 144
L NN + LP +G L L+ L L GN LS Q+I NL
Sbjct: 180 DLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEIGNL 219
Score = 61.6 bits (148), Expect = 2e-09
Identities = 32/95 (33%), Positives = 57/95 (60%)
Query: 45 VRSLSTSLWSLTHLTALHLNDNYLSRIPPDIAKLHNLVYLDLSSNKLRSLPAELGNMVSL 104
++SL ++ +L +L +L L +N L+ +P + +L L LDL +N++ +LP +G ++ L
Sbjct: 140 LQSLPENIGNLYNLASLELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALLHL 199
Query: 105 RELLLNNNLLRVLPYELGRLFQLQTLGLKGNPLSQ 139
++L L+ N L LP E+G L L L + N L +
Sbjct: 200 KDLWLDGNQLSELPQEIGNLKNLLCLDVSENRLER 234
Score = 60.5 bits (145), Expect = 4e-09
Identities = 38/100 (38%), Positives = 51/100 (51%), Gaps = 1/100 (1%)
Query: 39 LEIS-GRVRSLSTSLWSLTHLTALHLNDNYLSRIPPDIAKLHNLVYLDLSSNKLRSLPAE 97
L++S R+ L + LT LT L ++ N L IP I KL L L + N+L LP
Sbjct: 225 LDVSENRLERLPEEISGLTSLTDLVISQNLLETIPDGIGKLKKLSILKVDQNRLTQLPEA 284
Query: 98 LGNMVSLRELLLNNNLLRVLPYELGRLFQLQTLGLKGNPL 137
+G SL EL+L N L LP +G+L +L L N L
Sbjct: 285 VGECESLTELVLTENQLLTLPKSIGKLKKLSNLNADRNKL 324
Score = 56.2 bits (134), Expect = 8e-08
Identities = 41/125 (32%), Positives = 59/125 (47%), Gaps = 8/125 (6%)
Query: 44 RVRSLSTSLWSLTHLTALHLNDNYLSRIPPDIAKLHNLVYLDLSSNKLRSLPAELGNMVS 103
R+ L ++ LT L L +N L +P I KL L L+ NKL SLP E+G S
Sbjct: 277 RLTQLPEAVGECESLTELVLTENQLLTLPKSIGKLKKLSNLNADRNKLVSLPKEIGGCCS 336
Query: 104 LRELLLNNNLLRVLPYELGRLFQLQTLGLKGN-----PLSQDILN---LYQDPDGTRKLL 155
L + +N L +P E+ + +L L + GN PLS L L+ + ++ LL
Sbjct: 337 LTVFCVRDNRLTRIPAEVSQATELHVLDVAGNRLLHLPLSLTALKLKALWLSDNQSQPLL 396
Query: 156 NFMLD 160
F D
Sbjct: 397 TFQTD 401
Score = 53.9 bits (128), Expect = 4e-07
Identities = 43/153 (28%), Positives = 69/153 (45%), Gaps = 5/153 (3%)
Query: 15 DPRRIYTIMSAEEVANGKKSHWAELEISGRVRSLSTSLWSLTHLTALHLNDNYLSRIPPD 74
D R + EE+ +S L + ++R L + L L L L+DN + R+PP+
Sbjct: 18 DKRHCSLVYVPEEIYRYARSLEELLLDANQLRELPEQFFQLVKLRKLGLSDNEIQRLPPE 77
Query: 75 IAKLHNLVYLDLSSNKLRSLPAELGNMVSLRELLLNNNLLRVLPYELGRLFQLQTLGLKG 134
IA LV LD+S N++ +P + +L+ + N L LP L L L +
Sbjct: 78 IANFMQLVELDVSRNEIPEIPESISFCKALQVADFSGNPLTRLPESFPELQNLTCLSVND 137
Query: 135 ---NPLSQDILNLYQ--DPDGTRKLLNFMLDNL 162
L ++I NLY + LL ++ D+L
Sbjct: 138 ISLQSLPENIGNLYNLASLELRENLLTYLPDSL 170
Score = 53.9 bits (128), Expect = 4e-07
Identities = 39/124 (31%), Positives = 60/124 (48%), Gaps = 5/124 (4%)
Query: 38 ELEIS-GRVRSLSTSLWSLTHLTALHLNDNYLSRIPPDIAKLHNLVYLDLSSNKLRSLPA 96
EL++S + + S+ L + N L+R+P +L NL L ++ L+SLP
Sbjct: 86 ELDVSRNEIPEIPESISFCKALQVADFSGNPLTRLPESFPELQNLTCLSVNDISLQSLPE 145
Query: 97 ELGNMVSLRELLLNNNLLRVLPYELGRLFQLQTLGLKGNPLSQDILNLYQDPDGTRKLLN 156
+GN+ +L L L NLL LP L +L +L+ L L N +I NL + L +
Sbjct: 146 NIGNLYNLASLELRENLLTYLPDSLTQLRRLEELDLGNN----EIYNLPESIGALLHLKD 201
Query: 157 FMLD 160
LD
Sbjct: 202 LWLD 205
Score = 50.8 bits (120), Expect = 3e-06
Identities = 42/129 (32%), Positives = 62/129 (48%), Gaps = 6/129 (4%)
Query: 31 GKKSHWAELEISGRVRS-LSTSLWSLTHLTALHLNDNYLSRIPPDIAKLHNLVYLDLSSN 89
G + A LE+ + + L SL L L L L +N + +P I L +L L L N
Sbjct: 148 GNLYNLASLELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLDGN 207
Query: 90 KLRSLPAELGNMVSLRELLLNNNLLRVLPYELGRLFQLQTLGLKGNPLSQDILNLYQDPD 149
+L LP E+GN+ +L L ++ N L LP E+ L L L +SQ++L D
Sbjct: 208 QLSELPQEIGNLKNLLCLDVSENRLERLPEEISGLTSLTDL-----VISQNLLETIPDGI 262
Query: 150 GTRKLLNFM 158
G K L+ +
Sbjct: 263 GKLKKLSIL 271
Score = 45.1 bits (105), Expect = 2e-04
Identities = 25/95 (26%), Positives = 49/95 (51%)
Query: 45 VRSLSTSLWSLTHLTALHLNDNYLSRIPPDIAKLHNLVYLDLSSNKLRSLPAELGNMVSL 104
+ ++ + L L+ L ++ N L+++P + + +L L L+ N+L +LP +G + L
Sbjct: 255 LETIPDGIGKLKKLSILKVDQNRLTQLPEAVGECESLTELVLTENQLLTLPKSIGKLKKL 314
Query: 105 RELLLNNNLLRVLPYELGRLFQLQTLGLKGNPLSQ 139
L + N L LP E+G L ++ N L++
Sbjct: 315 SNLNADRNKLVSLPKEIGGCCSLTVFCVRDNRLTR 349
>gi|61742786 leucine rich repeat and death domain containing protein
isoform 3 [Homo sapiens]
Length = 893
Score = 72.4 bits (176), Expect = 1e-12
Identities = 41/94 (43%), Positives = 63/94 (67%)
Query: 44 RVRSLSTSLWSLTHLTALHLNDNYLSRIPPDIAKLHNLVYLDLSSNKLRSLPAELGNMVS 103
R+++L +L +L+ L L L+ N L +PP+I L +L+ L+L+SN+L+SLPA L + S
Sbjct: 182 RLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRS 241
Query: 104 LRELLLNNNLLRVLPYELGRLFQLQTLGLKGNPL 137
LR L+L++NLL +P +L RL L L L+ N L
Sbjct: 242 LRLLVLHSNLLASVPADLARLPLLTRLDLRDNQL 275
Score = 61.2 bits (147), Expect = 2e-09
Identities = 48/131 (36%), Positives = 68/131 (51%), Gaps = 2/131 (1%)
Query: 48 LSTSLWSLTHLTALHLNDNYLSRIPPDIAKLHNLVYLDLSSNKLRSLPAELGNMVSLREL 107
L +L +L LT L + N L +PP + L L LDLS N L +LP E+G + SL EL
Sbjct: 163 LPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLEL 222
Query: 108 LLNNNLLRVLPYELGRLFQLQTLGLKGNPLSQDILNLYQDPDGTRKLLNFMLDNLAVHPE 167
L +N L+ LP L L L+ L L N L+ +L + P TR L+ + L P
Sbjct: 223 NLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTR--LDLRDNQLRDLPP 280
Query: 168 QLPPRPWITLK 178
+L P++ L+
Sbjct: 281 ELLDAPFVRLQ 291
Score = 60.5 bits (145), Expect = 4e-09
Identities = 49/146 (33%), Positives = 74/146 (50%), Gaps = 7/146 (4%)
Query: 34 SHWAELEIS-GRVRSLSTSLWSLTHLTALHLNDNYLSRIPPDIAKLHNLVYLDLSSNKLR 92
+H A L++S + +L + + L AL L+ N LS +P + L L +L ++ N+L+
Sbjct: 125 AHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQ 184
Query: 93 SLPAELGNMVSLRELLLNNNLLRVLPYELGRLFQLQTLGLKGNPLSQDILNLYQDPDGTR 152
+LP LG + +L+ L L+ NLL LP E+G L L L L N L +L G R
Sbjct: 185 TLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQ----SLPASLAGLR 240
Query: 153 KLLNFMLDN--LAVHPEQLPPRPWIT 176
L +L + LA P L P +T
Sbjct: 241 SLRLLVLHSNLLASVPADLARLPLLT 266
Score = 53.9 bits (128), Expect = 4e-07
Identities = 36/97 (37%), Positives = 49/97 (50%)
Query: 41 ISGRVRSLSTSLWSLTHLTALHLNDNYLSRIPPDIAKLHNLVYLDLSSNKLRSLPAELGN 100
+ G + +L L L HL L L+ N L +P + ++ L L LS N L LP LG
Sbjct: 110 LRGALTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGA 169
Query: 101 MVSLRELLLNNNLLRVLPYELGRLFQLQTLGLKGNPL 137
+ +L L + +N L+ LP LG L LQ L L N L
Sbjct: 170 LPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLL 206
Score = 48.5 bits (114), Expect = 2e-05
Identities = 27/57 (47%), Positives = 35/57 (61%)
Query: 42 SGRVRSLSTSLWSLTHLTALHLNDNYLSRIPPDIAKLHNLVYLDLSSNKLRSLPAEL 98
S R++SL SL L L L L+ N L+ +P D+A+L L LDL N+LR LP EL
Sbjct: 226 SNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 282
>gi|61742784 leucine rich repeat and death domain containing protein
isoform 1 [Homo sapiens]
Length = 910
Score = 72.4 bits (176), Expect = 1e-12
Identities = 41/94 (43%), Positives = 63/94 (67%)
Query: 44 RVRSLSTSLWSLTHLTALHLNDNYLSRIPPDIAKLHNLVYLDLSSNKLRSLPAELGNMVS 103
R+++L +L +L+ L L L+ N L +PP+I L +L+ L+L+SN+L+SLPA L + S
Sbjct: 182 RLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRS 241
Query: 104 LRELLLNNNLLRVLPYELGRLFQLQTLGLKGNPL 137
LR L+L++NLL +P +L RL L L L+ N L
Sbjct: 242 LRLLVLHSNLLASVPADLARLPLLTRLDLRDNQL 275
Score = 61.2 bits (147), Expect = 2e-09
Identities = 48/131 (36%), Positives = 68/131 (51%), Gaps = 2/131 (1%)
Query: 48 LSTSLWSLTHLTALHLNDNYLSRIPPDIAKLHNLVYLDLSSNKLRSLPAELGNMVSLREL 107
L +L +L LT L + N L +PP + L L LDLS N L +LP E+G + SL EL
Sbjct: 163 LPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLEL 222
Query: 108 LLNNNLLRVLPYELGRLFQLQTLGLKGNPLSQDILNLYQDPDGTRKLLNFMLDNLAVHPE 167
L +N L+ LP L L L+ L L N L+ +L + P TR L+ + L P
Sbjct: 223 NLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTR--LDLRDNQLRDLPP 280
Query: 168 QLPPRPWITLK 178
+L P++ L+
Sbjct: 281 ELLDAPFVRLQ 291
Score = 60.5 bits (145), Expect = 4e-09
Identities = 49/146 (33%), Positives = 74/146 (50%), Gaps = 7/146 (4%)
Query: 34 SHWAELEIS-GRVRSLSTSLWSLTHLTALHLNDNYLSRIPPDIAKLHNLVYLDLSSNKLR 92
+H A L++S + +L + + L AL L+ N LS +P + L L +L ++ N+L+
Sbjct: 125 AHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQ 184
Query: 93 SLPAELGNMVSLRELLLNNNLLRVLPYELGRLFQLQTLGLKGNPLSQDILNLYQDPDGTR 152
+LP LG + +L+ L L+ NLL LP E+G L L L L N L +L G R
Sbjct: 185 TLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQ----SLPASLAGLR 240
Query: 153 KLLNFMLDN--LAVHPEQLPPRPWIT 176
L +L + LA P L P +T
Sbjct: 241 SLRLLVLHSNLLASVPADLARLPLLT 266
Score = 53.9 bits (128), Expect = 4e-07
Identities = 36/97 (37%), Positives = 49/97 (50%)
Query: 41 ISGRVRSLSTSLWSLTHLTALHLNDNYLSRIPPDIAKLHNLVYLDLSSNKLRSLPAELGN 100
+ G + +L L L HL L L+ N L +P + ++ L L LS N L LP LG
Sbjct: 110 LRGALTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGA 169
Query: 101 MVSLRELLLNNNLLRVLPYELGRLFQLQTLGLKGNPL 137
+ +L L + +N L+ LP LG L LQ L L N L
Sbjct: 170 LPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLL 206
Score = 48.5 bits (114), Expect = 2e-05
Identities = 27/57 (47%), Positives = 35/57 (61%)
Query: 42 SGRVRSLSTSLWSLTHLTALHLNDNYLSRIPPDIAKLHNLVYLDLSSNKLRSLPAEL 98
S R++SL SL L L L L+ N L+ +P D+A+L L LDL N+LR LP EL
Sbjct: 226 SNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 282
>gi|61742782 leucine rich repeat and death domain containing protein
isoform 2 [Homo sapiens]
Length = 753
Score = 72.4 bits (176), Expect = 1e-12
Identities = 41/94 (43%), Positives = 63/94 (67%)
Query: 44 RVRSLSTSLWSLTHLTALHLNDNYLSRIPPDIAKLHNLVYLDLSSNKLRSLPAELGNMVS 103
R+++L +L +L+ L L L+ N L +PP+I L +L+ L+L+SN+L+SLPA L + S
Sbjct: 36 RLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRS 95
Query: 104 LRELLLNNNLLRVLPYELGRLFQLQTLGLKGNPL 137
LR L+L++NLL +P +L RL L L L+ N L
Sbjct: 96 LRLLVLHSNLLASVPADLARLPLLTRLDLRDNQL 129
Score = 61.2 bits (147), Expect = 2e-09
Identities = 48/131 (36%), Positives = 68/131 (51%), Gaps = 2/131 (1%)
Query: 48 LSTSLWSLTHLTALHLNDNYLSRIPPDIAKLHNLVYLDLSSNKLRSLPAELGNMVSLREL 107
L +L +L LT L + N L +PP + L L LDLS N L +LP E+G + SL EL
Sbjct: 17 LPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLEL 76
Query: 108 LLNNNLLRVLPYELGRLFQLQTLGLKGNPLSQDILNLYQDPDGTRKLLNFMLDNLAVHPE 167
L +N L+ LP L L L+ L L N L+ +L + P TR L+ + L P
Sbjct: 77 NLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTR--LDLRDNQLRDLPP 134
Query: 168 QLPPRPWITLK 178
+L P++ L+
Sbjct: 135 ELLDAPFVRLQ 145
Score = 55.8 bits (133), Expect = 1e-07
Identities = 44/121 (36%), Positives = 62/121 (51%), Gaps = 6/121 (4%)
Query: 58 LTALHLNDNYLSRIPPDIAKLHNLVYLDLSSNKLRSLPAELGNMVSLRELLLNNNLLRVL 117
L AL L+ N LS +P + L L +L ++ N+L++LP LG + +L+ L L+ NLL L
Sbjct: 4 LGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTL 63
Query: 118 PYELGRLFQLQTLGLKGNPLSQDILNLYQDPDGTRKLLNFMLDN--LAVHPEQLPPRPWI 175
P E+G L L L L N L +L G R L +L + LA P L P +
Sbjct: 64 PPEIGGLGSLLELNLASNRLQ----SLPASLAGLRSLRLLVLHSNLLASVPADLARLPLL 119
Query: 176 T 176
T
Sbjct: 120 T 120
Score = 48.5 bits (114), Expect = 2e-05
Identities = 27/57 (47%), Positives = 35/57 (61%)
Query: 42 SGRVRSLSTSLWSLTHLTALHLNDNYLSRIPPDIAKLHNLVYLDLSSNKLRSLPAEL 98
S R++SL SL L L L L+ N L+ +P D+A+L L LDL N+LR LP EL
Sbjct: 80 SNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 136
Score = 36.6 bits (83), Expect = 0.062
Identities = 25/60 (41%), Positives = 31/60 (51%)
Query: 78 LHNLVYLDLSSNKLRSLPAELGNMVSLRELLLNNNLLRVLPYELGRLFQLQTLGLKGNPL 137
+ L L LS N L LP LG + +L L + +N L+ LP LG L LQ L L N L
Sbjct: 1 MRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLL 60
>gi|55770895 ERBB2 interacting protein isoform 7 [Homo sapiens]
Length = 1302
Score = 72.0 bits (175), Expect = 1e-12
Identities = 46/125 (36%), Positives = 74/125 (59%), Gaps = 5/125 (4%)
Query: 38 ELEIS-GRVRSLSTSLWSLTHLTALHLNDNYLSRIPPDIAKLHNLVYLDLSSNKLRSLPA 96
EL+ S V +L +S+ LT+L + NYL ++PP+I N+ L L SNKL +LP
Sbjct: 303 ELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPE 362
Query: 97 ELGNMVSLRELLLNNNLLRVLPYELGRLFQLQTLGLKGNPLSQDILNLYQDPDG-TRK-- 153
E+G+M L+ + L++N L+ LP+ +L QL + L N S+ ++ L ++ D T+K
Sbjct: 363 EMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQ-SKPLIPLQKETDSETQKMV 421
Query: 154 LLNFM 158
L N+M
Sbjct: 422 LTNYM 426
Score = 56.2 bits (134), Expect = 8e-08
Identities = 30/96 (31%), Positives = 54/96 (56%)
Query: 42 SGRVRSLSTSLWSLTHLTALHLNDNYLSRIPPDIAKLHNLVYLDLSSNKLRSLPAELGNM 101
S ++ L ++ SL ++T L +++N L +P I L ++ LD S N++ +LP+ +G +
Sbjct: 262 SNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQL 321
Query: 102 VSLRELLLNNNLLRVLPYELGRLFQLQTLGLKGNPL 137
+LR ++N L+ LP E+G + L L N L
Sbjct: 322 TNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKL 357
Score = 51.6 bits (122), Expect = 2e-06
Identities = 32/103 (31%), Positives = 55/103 (53%), Gaps = 1/103 (0%)
Query: 38 ELEISGR-VRSLSTSLWSLTHLTALHLNDNYLSRIPPDIAKLHNLVYLDLSSNKLRSLPA 96
EL++S ++ ++ + LT + + N +S++P ++L NL L L+ L LPA
Sbjct: 96 ELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPA 155
Query: 97 ELGNMVSLRELLLNNNLLRVLPYELGRLFQLQTLGLKGNPLSQ 139
G + L+ L L N L++LP + RL QL+ L L N ++
Sbjct: 156 NFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTE 198
Score = 51.6 bits (122), Expect = 2e-06
Identities = 30/102 (29%), Positives = 52/102 (50%), Gaps = 1/102 (0%)
Query: 39 LEIS-GRVRSLSTSLWSLTHLTALHLNDNYLSRIPPDIAKLHNLVYLDLSSNKLRSLPAE 97
L++S + + + + +L L L+ N L ++P I L N+ L + N+L LP
Sbjct: 235 LDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDS 294
Query: 98 LGNMVSLRELLLNNNLLRVLPYELGRLFQLQTLGLKGNPLSQ 139
+G ++S+ EL + N + LP +G+L L+T N L Q
Sbjct: 295 IGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQ 336
Score = 51.2 bits (121), Expect = 2e-06
Identities = 36/119 (30%), Positives = 54/119 (45%), Gaps = 23/119 (19%)
Query: 42 SGRVRSLSTSLWSLTHLTALHLNDNYLSRIPPDIAKLHNLVYLDLSSNKLRSLPAELGN- 100
+ ++ L L++ L L L DN L+ +P IA L NL LD+S N ++ P + N
Sbjct: 55 ANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNC 114
Query: 101 ----------------------MVSLRELLLNNNLLRVLPYELGRLFQLQTLGLKGNPL 137
+++L +L LN+ L LP GRL +LQ L L+ N L
Sbjct: 115 KVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQL 173
Score = 50.4 bits (119), Expect = 4e-06
Identities = 32/109 (29%), Positives = 54/109 (49%), Gaps = 3/109 (2%)
Query: 27 EVANGKKSHWAELEISGRVRSLSTSLWSLTHLTALHLNDNYLSRIPPDIAKLHNLVYLDL 86
E +G K W + + R+ + + SL LT L ++ N + + I+ NL L L
Sbjct: 204 EQLSGLKEFWMD---ANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLL 260
Query: 87 SSNKLRSLPAELGNMVSLRELLLNNNLLRVLPYELGRLFQLQTLGLKGN 135
SSN L+ LP +G++ ++ L ++ N L LP +G L ++ L N
Sbjct: 261 SSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFN 309
Score = 48.5 bits (114), Expect = 2e-05
Identities = 30/99 (30%), Positives = 50/99 (50%), Gaps = 7/99 (7%)
Query: 58 LTALHLNDNYLSRIPPDIAKLHNLVYLDLSSNKLRSLPAELGNMVSLRELLLNNNLLRVL 117
L L+L+ N + +P + +L L L N L +LPA + N+++LREL ++ N ++
Sbjct: 48 LEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEF 107
Query: 118 PYELGRLFQLQTLGLKGNPLSQDILNLYQDPDGTRKLLN 156
P + L + NP+S + PDG +LLN
Sbjct: 108 PENIKNCKVLTIVEASVNPIS-------KLPDGFSQLLN 139
Score = 48.5 bits (114), Expect = 2e-05
Identities = 29/86 (33%), Positives = 46/86 (53%)
Query: 52 LWSLTHLTALHLNDNYLSRIPPDIAKLHNLVYLDLSSNKLRSLPAELGNMVSLRELLLNN 111
L L+ L ++ N L+ IP I L L YLD+S N + + + +L++LLL++
Sbjct: 203 LEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSS 262
Query: 112 NLLRVLPYELGRLFQLQTLGLKGNPL 137
N L+ LP +G L + TL + N L
Sbjct: 263 NSLQQLPETIGSLKNITTLKIDENQL 288
Score = 48.1 bits (113), Expect = 2e-05
Identities = 28/94 (29%), Positives = 46/94 (48%)
Query: 45 VRSLSTSLWSLTHLTALHLNDNYLSRIPPDIAKLHNLVYLDLSSNKLRSLPAELGNMVSL 104
+ L L +LT L+LND +L +P + +L L L+L N+L+ LP + + L
Sbjct: 127 ISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQL 186
Query: 105 RELLLNNNLLRVLPYELGRLFQLQTLGLKGNPLS 138
L L +N +P L +L L+ + N L+
Sbjct: 187 ERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLT 220
Score = 48.1 bits (113), Expect = 2e-05
Identities = 28/90 (31%), Positives = 46/90 (51%)
Query: 48 LSTSLWSLTHLTALHLNDNYLSRIPPDIAKLHNLVYLDLSSNKLRSLPAELGNMVSLREL 107
L S+ L + L + N + +P I +L NL N L+ LP E+G+ ++ L
Sbjct: 291 LPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVL 350
Query: 108 LLNNNLLRVLPYELGRLFQLQTLGLKGNPL 137
L++N L LP E+G + +L+ + L N L
Sbjct: 351 FLHSNKLETLPEEMGDMQKLKVINLSDNRL 380
Score = 47.4 bits (111), Expect = 4e-05
Identities = 29/88 (32%), Positives = 43/88 (48%)
Query: 48 LSTSLWSLTHLTALHLNDNYLSRIPPDIAKLHNLVYLDLSSNKLRSLPAELGNMVSLREL 107
L + LT L L L +N L +P + +L L LDL SN+ +P L + L+E
Sbjct: 153 LPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEF 212
Query: 108 LLNNNLLRVLPYELGRLFQLQTLGLKGN 135
++ N L +P +G L QL L + N
Sbjct: 213 WMDANRLTFIPGFIGSLKQLTYLDVSKN 240
>gi|8923909 ERBB2 interacting protein isoform 2 [Homo sapiens]
Length = 1371
Score = 72.0 bits (175), Expect = 1e-12
Identities = 46/125 (36%), Positives = 74/125 (59%), Gaps = 5/125 (4%)
Query: 38 ELEIS-GRVRSLSTSLWSLTHLTALHLNDNYLSRIPPDIAKLHNLVYLDLSSNKLRSLPA 96
EL+ S V +L +S+ LT+L + NYL ++PP+I N+ L L SNKL +LP
Sbjct: 303 ELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPE 362
Query: 97 ELGNMVSLRELLLNNNLLRVLPYELGRLFQLQTLGLKGNPLSQDILNLYQDPDG-TRK-- 153
E+G+M L+ + L++N L+ LP+ +L QL + L N S+ ++ L ++ D T+K
Sbjct: 363 EMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQ-SKPLIPLQKETDSETQKMV 421
Query: 154 LLNFM 158
L N+M
Sbjct: 422 LTNYM 426
Score = 56.2 bits (134), Expect = 8e-08
Identities = 30/96 (31%), Positives = 54/96 (56%)
Query: 42 SGRVRSLSTSLWSLTHLTALHLNDNYLSRIPPDIAKLHNLVYLDLSSNKLRSLPAELGNM 101
S ++ L ++ SL ++T L +++N L +P I L ++ LD S N++ +LP+ +G +
Sbjct: 262 SNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQL 321
Query: 102 VSLRELLLNNNLLRVLPYELGRLFQLQTLGLKGNPL 137
+LR ++N L+ LP E+G + L L N L
Sbjct: 322 TNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKL 357
Score = 51.6 bits (122), Expect = 2e-06
Identities = 32/103 (31%), Positives = 55/103 (53%), Gaps = 1/103 (0%)
Query: 38 ELEISGR-VRSLSTSLWSLTHLTALHLNDNYLSRIPPDIAKLHNLVYLDLSSNKLRSLPA 96
EL++S ++ ++ + LT + + N +S++P ++L NL L L+ L LPA
Sbjct: 96 ELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPA 155
Query: 97 ELGNMVSLRELLLNNNLLRVLPYELGRLFQLQTLGLKGNPLSQ 139
G + L+ L L N L++LP + RL QL+ L L N ++
Sbjct: 156 NFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTE 198
Score = 51.6 bits (122), Expect = 2e-06
Identities = 30/102 (29%), Positives = 52/102 (50%), Gaps = 1/102 (0%)
Query: 39 LEIS-GRVRSLSTSLWSLTHLTALHLNDNYLSRIPPDIAKLHNLVYLDLSSNKLRSLPAE 97
L++S + + + + +L L L+ N L ++P I L N+ L + N+L LP
Sbjct: 235 LDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDS 294
Query: 98 LGNMVSLRELLLNNNLLRVLPYELGRLFQLQTLGLKGNPLSQ 139
+G ++S+ EL + N + LP +G+L L+T N L Q
Sbjct: 295 IGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQ 336
Score = 51.2 bits (121), Expect = 2e-06
Identities = 36/119 (30%), Positives = 54/119 (45%), Gaps = 23/119 (19%)
Query: 42 SGRVRSLSTSLWSLTHLTALHLNDNYLSRIPPDIAKLHNLVYLDLSSNKLRSLPAELGN- 100
+ ++ L L++ L L L DN L+ +P IA L NL LD+S N ++ P + N
Sbjct: 55 ANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNC 114
Query: 101 ----------------------MVSLRELLLNNNLLRVLPYELGRLFQLQTLGLKGNPL 137
+++L +L LN+ L LP GRL +LQ L L+ N L
Sbjct: 115 KVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQL 173
Score = 50.4 bits (119), Expect = 4e-06
Identities = 32/109 (29%), Positives = 54/109 (49%), Gaps = 3/109 (2%)
Query: 27 EVANGKKSHWAELEISGRVRSLSTSLWSLTHLTALHLNDNYLSRIPPDIAKLHNLVYLDL 86
E +G K W + + R+ + + SL LT L ++ N + + I+ NL L L
Sbjct: 204 EQLSGLKEFWMD---ANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLL 260
Query: 87 SSNKLRSLPAELGNMVSLRELLLNNNLLRVLPYELGRLFQLQTLGLKGN 135
SSN L+ LP +G++ ++ L ++ N L LP +G L ++ L N
Sbjct: 261 SSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFN 309
Score = 48.5 bits (114), Expect = 2e-05
Identities = 30/99 (30%), Positives = 50/99 (50%), Gaps = 7/99 (7%)
Query: 58 LTALHLNDNYLSRIPPDIAKLHNLVYLDLSSNKLRSLPAELGNMVSLRELLLNNNLLRVL 117
L L+L+ N + +P + +L L L N L +LPA + N+++LREL ++ N ++
Sbjct: 48 LEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEF 107
Query: 118 PYELGRLFQLQTLGLKGNPLSQDILNLYQDPDGTRKLLN 156
P + L + NP+S + PDG +LLN
Sbjct: 108 PENIKNCKVLTIVEASVNPIS-------KLPDGFSQLLN 139
Score = 48.5 bits (114), Expect = 2e-05
Identities = 29/86 (33%), Positives = 46/86 (53%)
Query: 52 LWSLTHLTALHLNDNYLSRIPPDIAKLHNLVYLDLSSNKLRSLPAELGNMVSLRELLLNN 111
L L+ L ++ N L+ IP I L L YLD+S N + + + +L++LLL++
Sbjct: 203 LEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSS 262
Query: 112 NLLRVLPYELGRLFQLQTLGLKGNPL 137
N L+ LP +G L + TL + N L
Sbjct: 263 NSLQQLPETIGSLKNITTLKIDENQL 288
Score = 48.1 bits (113), Expect = 2e-05
Identities = 28/94 (29%), Positives = 46/94 (48%)
Query: 45 VRSLSTSLWSLTHLTALHLNDNYLSRIPPDIAKLHNLVYLDLSSNKLRSLPAELGNMVSL 104
+ L L +LT L+LND +L +P + +L L L+L N+L+ LP + + L
Sbjct: 127 ISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQL 186
Query: 105 RELLLNNNLLRVLPYELGRLFQLQTLGLKGNPLS 138
L L +N +P L +L L+ + N L+
Sbjct: 187 ERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLT 220
Score = 48.1 bits (113), Expect = 2e-05
Identities = 28/90 (31%), Positives = 46/90 (51%)
Query: 48 LSTSLWSLTHLTALHLNDNYLSRIPPDIAKLHNLVYLDLSSNKLRSLPAELGNMVSLREL 107
L S+ L + L + N + +P I +L NL N L+ LP E+G+ ++ L
Sbjct: 291 LPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVL 350
Query: 108 LLNNNLLRVLPYELGRLFQLQTLGLKGNPL 137
L++N L LP E+G + +L+ + L N L
Sbjct: 351 FLHSNKLETLPEEMGDMQKLKVINLSDNRL 380
Score = 47.4 bits (111), Expect = 4e-05
Identities = 29/88 (32%), Positives = 43/88 (48%)
Query: 48 LSTSLWSLTHLTALHLNDNYLSRIPPDIAKLHNLVYLDLSSNKLRSLPAELGNMVSLREL 107
L + LT L L L +N L +P + +L L LDL SN+ +P L + L+E
Sbjct: 153 LPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEF 212
Query: 108 LLNNNLLRVLPYELGRLFQLQTLGLKGN 135
++ N L +P +G L QL L + N
Sbjct: 213 WMDANRLTFIPGFIGSLKQLTYLDVSKN 240
>gi|6912638 ras suppressor protein 1 isoform 1 [Homo sapiens]
Length = 277
Score = 70.1 bits (170), Expect = 5e-12
Identities = 44/103 (42%), Positives = 56/103 (54%), Gaps = 3/103 (2%)
Query: 47 SLSTSLWSLTHLTALHLNDNYLSRIPPDIAKLHNLVYLDLSSNKLRSLPAELGNMVSLRE 106
SL + + LT L AL+L+DN +PPDI KL L L L N L SLP E+G + L+E
Sbjct: 125 SLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKE 184
Query: 107 LLLNNNLLRVLPYELGRL---FQLQTLGLKGNPLSQDILNLYQ 146
L + N L VLP ELG L Q Q + NP I + +Q
Sbjct: 185 LHIQGNRLTVLPPELGNLDLTGQKQVFKAENNPWVTPIADQFQ 227
Score = 65.9 bits (159), Expect = 1e-10
Identities = 40/118 (33%), Positives = 67/118 (56%), Gaps = 3/118 (2%)
Query: 28 VANGKKSHWAELEISGRVRSLS---TSLWSLTHLTALHLNDNYLSRIPPDIAKLHNLVYL 84
V ++ + E+++S R S L++L+H+T L L+ N L+ +PP+IA+L NL L
Sbjct: 9 VEESREKNQPEVDMSDRGISNMLDVNGLFTLSHITQLVLSHNKLTMVPPNIAELKNLEVL 68
Query: 85 DLSSNKLRSLPAELGNMVSLRELLLNNNLLRVLPYELGRLFQLQTLGLKGNPLSQDIL 142
+ +N++ LP ++ ++ L+ L L N L LP G L L+ L L N LS++ L
Sbjct: 69 NFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSL 126
>gi|34577083 ras suppressor protein 1 isoform 2 [Homo sapiens]
Length = 224
Score = 70.1 bits (170), Expect = 5e-12
Identities = 44/103 (42%), Positives = 56/103 (54%), Gaps = 3/103 (2%)
Query: 47 SLSTSLWSLTHLTALHLNDNYLSRIPPDIAKLHNLVYLDLSSNKLRSLPAELGNMVSLRE 106
SL + + LT L AL+L+DN +PPDI KL L L L N L SLP E+G + L+E
Sbjct: 72 SLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKE 131
Query: 107 LLLNNNLLRVLPYELGRL---FQLQTLGLKGNPLSQDILNLYQ 146
L + N L VLP ELG L Q Q + NP I + +Q
Sbjct: 132 LHIQGNRLTVLPPELGNLDLTGQKQVFKAENNPWVTPIADQFQ 174
Score = 50.8 bits (120), Expect = 3e-06
Identities = 27/72 (37%), Positives = 42/72 (58%)
Query: 71 IPPDIAKLHNLVYLDLSSNKLRSLPAELGNMVSLRELLLNNNLLRVLPYELGRLFQLQTL 130
+PP+IA+L NL L+ +N++ LP ++ ++ L+ L L N L LP G L L+ L
Sbjct: 2 VPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVL 61
Query: 131 GLKGNPLSQDIL 142
L N LS++ L
Sbjct: 62 DLTYNNLSENSL 73
Score = 47.8 bits (112), Expect = 3e-05
Identities = 30/108 (27%), Positives = 51/108 (47%), Gaps = 25/108 (23%)
Query: 55 LTHLTALHLNDNYLSRIPPDIAKLHNLVYLDLSSNKLRSLPAELGN-------------- 100
L +L L+ +N + +P I+ L L +L+L N+L +LP G+
Sbjct: 9 LKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNL 68
Query: 101 -----------MVSLRELLLNNNLLRVLPYELGRLFQLQTLGLKGNPL 137
+ +LR L L++N +LP ++G+L +LQ L L+ N L
Sbjct: 69 SENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDL 116
>gi|21361633 leucine rich repeat containing 40 [Homo sapiens]
Length = 602
Score = 68.6 bits (166), Expect = 1e-11
Identities = 41/112 (36%), Positives = 65/112 (58%), Gaps = 1/112 (0%)
Query: 26 EEVANGKKSHWAELEISGRVRSLSTSLWSLTHLTALHLNDNYLSRIPPDIAKLHNLVYLD 85
EE+ N + L+ + +S L++L L L++N+L+ +P + L +LV L+
Sbjct: 145 EEITNLRNLKCLYLQ-HNELTCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVRLN 203
Query: 86 LSSNKLRSLPAELGNMVSLRELLLNNNLLRVLPYELGRLFQLQTLGLKGNPL 137
LSSN+L+SLPAE+ M L+ L N+NLL +P EL + L+ L L+ N L
Sbjct: 204 LSSNELKSLPAEINRMKRLKHLDCNSNLLETIPPELAGMESLELLYLRRNKL 255
Score = 59.3 bits (142), Expect = 9e-09
Identities = 35/97 (36%), Positives = 57/97 (58%)
Query: 42 SGRVRSLSTSLWSLTHLTALHLNDNYLSRIPPDIAKLHNLVYLDLSSNKLRSLPAELGNM 101
+ +++SL+ L L LT L ++DN L+ +P I +L NL L++S NKL+ LP E+ N+
Sbjct: 91 NNKLQSLTDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLKILPEEITNL 150
Query: 102 VSLRELLLNNNLLRVLPYELGRLFQLQTLGLKGNPLS 138
+L+ L L +N L + +L L+ L L N L+
Sbjct: 151 RNLKCLYLQHNELTCISEGFEQLSNLEDLDLSNNHLT 187
Score = 57.8 bits (138), Expect = 3e-08
Identities = 39/109 (35%), Positives = 66/109 (60%), Gaps = 10/109 (9%)
Query: 54 SLTHLTALHLNDNYLSRIPPDIAK-LHNLVYLDLSSNKLRSLPAELGNMVSLRELLLNNN 112
S + L LH+ +N + + + K L++++ LDL NKL+S+P E+ + SL L L+NN
Sbjct: 263 SCSLLKELHVGENQIEMLEAEHLKHLNSILVLDLRDNKLKSVPDEIILLRSLERLDLSNN 322
Query: 113 LLRVLPYELGRLFQLQTLGLKGNPL---SQDILNLYQDPDGTRKLLNFM 158
+ LPY LG L L+ L L+GNPL ++I++ GT+++L ++
Sbjct: 323 DISSLPYSLGNL-HLKFLALEGNPLRTIRREIIS-----KGTQEVLKYL 365
Score = 56.2 bits (134), Expect = 8e-08
Identities = 30/86 (34%), Positives = 52/86 (60%)
Query: 53 WSLTHLTALHLNDNYLSRIPPDIAKLHNLVYLDLSSNKLRSLPAELGNMVSLRELLLNNN 112
W T LT L +++N L + D+ L L LD+ N+L SLP+ + + +L++L +++N
Sbjct: 79 WEQTDLTKLIISNNKLQSLTDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHN 138
Query: 113 LLRVLPYELGRLFQLQTLGLKGNPLS 138
L++LP E+ L L+ L L+ N L+
Sbjct: 139 KLKILPEEITNLRNLKCLYLQHNELT 164
Score = 55.1 bits (131), Expect = 2e-07
Identities = 32/86 (37%), Positives = 50/86 (58%), Gaps = 1/86 (1%)
Query: 34 SHWAELEISGR-VRSLSTSLWSLTHLTALHLNDNYLSRIPPDIAKLHNLVYLDLSSNKLR 92
S+ +L++S + ++ S SL+ L L+L+ N L +P +I ++ L +LD +SN L
Sbjct: 174 SNLEDLDLSNNHLTTVPASFSSLSSLVRLNLSSNELKSLPAEINRMKRLKHLDCNSNLLE 233
Query: 93 SLPAELGNMVSLRELLLNNNLLRVLP 118
++P EL M SL L L N LR LP
Sbjct: 234 TIPPELAGMESLELLYLRRNKLRFLP 259
Score = 54.7 bits (130), Expect = 2e-07
Identities = 33/94 (35%), Positives = 54/94 (57%)
Query: 44 RVRSLSTSLWSLTHLTALHLNDNYLSRIPPDIAKLHNLVYLDLSSNKLRSLPAELGNMVS 103
+++ L + +L +L L+L N L+ I +L NL LDLS+N L ++PA ++ S
Sbjct: 139 KLKILPEEITNLRNLKCLYLQHNELTCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSS 198
Query: 104 LRELLLNNNLLRVLPYELGRLFQLQTLGLKGNPL 137
L L L++N L+ LP E+ R+ +L+ L N L
Sbjct: 199 LVRLNLSSNELKSLPAEINRMKRLKHLDCNSNLL 232
Score = 50.4 bits (119), Expect = 4e-06
Identities = 28/73 (38%), Positives = 45/73 (61%)
Query: 63 LNDNYLSRIPPDIAKLHNLVYLDLSSNKLRSLPAELGNMVSLRELLLNNNLLRVLPYELG 122
L+ N LS I ++ L L +LDL +N L SLP E+ ++V L+ + L+ N ++LP L
Sbjct: 456 LSFNKLSFISLELCVLQKLTFLDLRNNFLNSLPEEMESLVRLQTINLSFNRFKMLPEVLY 515
Query: 123 RLFQLQTLGLKGN 135
R+F L+T+ + N
Sbjct: 516 RIFTLETILISNN 528
Score = 48.9 bits (115), Expect = 1e-05
Identities = 38/139 (27%), Positives = 61/139 (43%), Gaps = 26/139 (18%)
Query: 48 LSTSLWSLTHLTALHLNDNYLSRIPPDIAKLHNLVYLDLSSNKLRSLPAELGNMVSLREL 107
+S L L LT L L +N+L+ +P ++ L L ++LS N+ + LP L + +L +
Sbjct: 464 ISLELCVLQKLTFLDLRNNFLNSLPEEMESLVRLQTINLSFNRFKMLPEVLYRIFTLETI 523
Query: 108 LLNNNL------------------------LRVLPYELGRLFQLQTLGLKGNPLSQDILN 143
L++NN L +P ELG L+TL L GNP
Sbjct: 524 LISNNQVGSVDPQKMKMMENLTTLDLQNNDLLQIPPELGNCVNLRTLLLDGNPFRVPRAA 583
Query: 144 LYQDPDGTRKLLNFMLDNL 162
+ GT +L ++ D +
Sbjct: 584 ILM--KGTAAILEYLRDRI 600
Score = 48.9 bits (115), Expect = 1e-05
Identities = 28/74 (37%), Positives = 42/74 (56%), Gaps = 1/74 (1%)
Query: 44 RVRSLSTSLWSLTHLTALHLNDNYLSRIPPDIAKL-HNLVYLDLSSNKLRSLPAELGNMV 102
R + L L+ + L + +++N + + P K+ NL LDL +N L +P ELGN V
Sbjct: 506 RFKMLPEVLYRIFTLETILISNNQVGSVDPQKMKMMENLTTLDLQNNDLLQIPPELGNCV 565
Query: 103 SLRELLLNNNLLRV 116
+LR LLL+ N RV
Sbjct: 566 NLRTLLLDGNPFRV 579
Score = 46.6 bits (109), Expect = 6e-05
Identities = 30/79 (37%), Positives = 44/79 (55%), Gaps = 1/79 (1%)
Query: 58 LTALHLNDNYLSRIPPDIAKLHNLVY-LDLSSNKLRSLPAELGNMVSLRELLLNNNLLRV 116
+T+++ + N L IP + +L +V +DLS NKL + EL + L L L NN L
Sbjct: 427 VTSINFSKNQLCEIPKRMVELKEMVSDVDLSFNKLSFISLELCVLQKLTFLDLRNNFLNS 486
Query: 117 LPYELGRLFQLQTLGLKGN 135
LP E+ L +LQT+ L N
Sbjct: 487 LPEEMESLVRLQTINLSFN 505
>gi|40254924 leucine rich repeat containing 59 [Homo sapiens]
Length = 307
Score = 68.2 bits (165), Expect = 2e-11
Identities = 40/86 (46%), Positives = 52/86 (60%)
Query: 52 LWSLTHLTALHLNDNYLSRIPPDIAKLHNLVYLDLSSNKLRSLPAELGNMVSLRELLLNN 111
L +L T L L+ N L+ +P D L +LV LDLS NKL+ LPA+ G +V+L+ L L N
Sbjct: 35 LAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQLPADFGRLVNLQHLDLLN 94
Query: 112 NLLRVLPYELGRLFQLQTLGLKGNPL 137
N L LP +L L+ L LK NPL
Sbjct: 95 NKLVTLPVSFAQLKNLKWLDLKDNPL 120
Score = 51.2 bits (121), Expect = 2e-06
Identities = 27/71 (38%), Positives = 42/71 (59%)
Query: 44 RVRSLSTSLWSLTHLTALHLNDNYLSRIPPDIAKLHNLVYLDLSSNKLRSLPAELGNMVS 103
++ +L + LTHL L L+ N L ++P D +L NL +LDL +NKL +LP + +
Sbjct: 50 KLTTLPSDFCGLTHLVKLDLSKNKLQQLPADFGRLVNLQHLDLLNNKLVTLPVSFAQLKN 109
Query: 104 LRELLLNNNLL 114
L+ L L +N L
Sbjct: 110 LKWLDLKDNPL 120
Score = 48.9 bits (115), Expect = 1e-05
Identities = 31/78 (39%), Positives = 45/78 (57%), Gaps = 1/78 (1%)
Query: 61 LHLNDNYLSRIP-PDIAKLHNLVYLDLSSNKLRSLPAELGNMVSLRELLLNNNLLRVLPY 119
L L+ + L+ +P ++A L LDLS NKL +LP++ + L +L L+ N L+ LP
Sbjct: 20 LDLSLSDLNEVPVKELAALPKATILDLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQLPA 79
Query: 120 ELGRLFQLQTLGLKGNPL 137
+ GRL LQ L L N L
Sbjct: 80 DFGRLVNLQHLDLLNNKL 97
>gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens]
Length = 582
Score = 67.0 bits (162), Expect = 4e-11
Identities = 47/123 (38%), Positives = 70/123 (56%), Gaps = 4/123 (3%)
Query: 26 EEVANGKKSHWAELEISGR-VRSLSTSLWSLTHLTALHLNDNYLSRIPPDIAKLHNLVYL 84
+E+ ++ + L++S R + L +S+ LT LT L+L N L +P ++ L NL+ L
Sbjct: 92 KELNKCREENSMRLDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTL 151
Query: 85 DLSSNKLRSLPAELGNMVSLRELLLNNNLLRVLPYELGRLFQLQTLGLKGNPLS---QDI 141
LS N L SLP L N+ LR L L +N LR +P + RL L TL L+ N ++ +DI
Sbjct: 152 ALSENSLTSLPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDI 211
Query: 142 LNL 144
NL
Sbjct: 212 KNL 214
Score = 67.0 bits (162), Expect = 4e-11
Identities = 41/126 (32%), Positives = 70/126 (55%), Gaps = 2/126 (1%)
Query: 44 RVRSLSTSLWSLTHLTALHLNDNYLSRIPPDIAKLHNLVYLDLSSNKLRSLPAELGNMVS 103
R+ ++ + +L+ L+ L + +N + ++P +I +L NL+ LD++ N+L LP E+GN
Sbjct: 203 RITTVEKDIKNLSKLSMLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQ 262
Query: 104 LRELLLNNNLLRVLPYELGRLFQLQTLGLKGNPLSQDILNLYQDPDGTRKLLNFMLDNLA 163
+ L L +N L LP +G L L LGL+ N LS +L + + LN +N++
Sbjct: 263 ITNLDLQHNELLDLPDTIGNLSSLSRLGLRYNRLSAIPRSLAK--CSALEELNLENNNIS 320
Query: 164 VHPEQL 169
PE L
Sbjct: 321 TLPESL 326
Score = 64.3 bits (155), Expect = 3e-10
Identities = 32/80 (40%), Positives = 54/80 (67%)
Query: 58 LTALHLNDNYLSRIPPDIAKLHNLVYLDLSSNKLRSLPAELGNMVSLRELLLNNNLLRVL 117
L+ L++ DN L+ +P D ++V L+L++N+L +P ++ +VSL L+L+NNLL+ L
Sbjct: 381 LSKLNMKDNQLTSLPLDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKL 440
Query: 118 PYELGRLFQLQTLGLKGNPL 137
P+ LG L +L+ L L+ N L
Sbjct: 441 PHGLGNLRKLRELDLEENKL 460
Score = 62.8 bits (151), Expect = 8e-10
Identities = 39/95 (41%), Positives = 54/95 (56%)
Query: 44 RVRSLSTSLWSLTHLTALHLNDNYLSRIPPDIAKLHNLVYLDLSSNKLRSLPAELGNMVS 103
++ SL + T + L+L N L++IP D++ L +L L LS+N L+ LP LGN+
Sbjct: 390 QLTSLPLDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRK 449
Query: 104 LRELLLNNNLLRVLPYELGRLFQLQTLGLKGNPLS 138
LREL L N L LP E+ L LQ L L N L+
Sbjct: 450 LRELDLEENKLESLPNEIAYLKDLQKLVLTNNQLT 484
Score = 60.8 bits (146), Expect = 3e-09
Identities = 35/84 (41%), Positives = 47/84 (55%)
Query: 55 LTHLTALHLNDNYLSRIPPDIAKLHNLVYLDLSSNKLRSLPAELGNMVSLRELLLNNNLL 114
L L L L++N L ++P + L L LDL NKL SLP E+ + L++L+L NN L
Sbjct: 424 LVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEENKLESLPNEIAYLKDLQKLVLTNNQL 483
Query: 115 RVLPYELGRLFQLQTLGLKGNPLS 138
LP +G L L LGL N L+
Sbjct: 484 TTLPRGIGHLTNLTHLGLGENLLT 507
Score = 60.5 bits (145), Expect = 4e-09
Identities = 36/112 (32%), Positives = 60/112 (53%), Gaps = 1/112 (0%)
Query: 26 EEVANGKKSHWAELEISGRVRSLSTSLWSLTHLTALHLNDNYLSRIPPDIAKLHNLVYLD 85
+ + N KK +L ++R + + ++ L LT L+L N ++ + DI L L L
Sbjct: 163 DSLDNLKKLRMLDLR-HNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSMLS 221
Query: 86 LSSNKLRSLPAELGNMVSLRELLLNNNLLRVLPYELGRLFQLQTLGLKGNPL 137
+ NK++ LPAE+G + +L L + +N L LP E+G Q+ L L+ N L
Sbjct: 222 IRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNEL 273
Score = 60.5 bits (145), Expect = 4e-09
Identities = 36/92 (39%), Positives = 53/92 (57%)
Query: 45 VRSLSTSLWSLTHLTALHLNDNYLSRIPPDIAKLHNLVYLDLSSNKLRSLPAELGNMVSL 104
++ L L +L L L L +N L +P +IA L +L L L++N+L +LP +G++ +L
Sbjct: 437 LKKLPHGLGNLRKLRELDLEENKLESLPNEIAYLKDLQKLVLTNNQLTTLPRGIGHLTNL 496
Query: 105 RELLLNNNLLRVLPYELGRLFQLQTLGLKGNP 136
L L NLL LP E+G L L+ L L NP
Sbjct: 497 THLGLGENLLTHLPEEIGTLENLEELYLNDNP 528
Score = 60.1 bits (144), Expect = 5e-09
Identities = 40/112 (35%), Positives = 59/112 (52%), Gaps = 2/112 (1%)
Query: 28 VANGKKSHWAELEISGRVRSLSTSLWSLTHLTALHLNDNYLSRIPPDIAKLHNLVYLDLS 87
+ N +K +LE ++ SL + L L L L +N L+ +P I L NL +L L
Sbjct: 444 LGNLRKLRELDLE-ENKLESLPNEIAYLKDLQKLVLTNNQLTTLPRGIGHLTNLTHLGLG 502
Query: 88 SNKLRSLPAELGNMVSLRELLLNNN-LLRVLPYELGRLFQLQTLGLKGNPLS 138
N L LP E+G + +L EL LN+N L LP+EL +L + ++ PLS
Sbjct: 503 ENLLTHLPEEIGTLENLEELYLNDNPNLHSLPFELALCSKLSIMSIENCPLS 554
Score = 52.8 bits (125), Expect = 8e-07
Identities = 30/98 (30%), Positives = 52/98 (53%)
Query: 42 SGRVRSLSTSLWSLTHLTALHLNDNYLSRIPPDIAKLHNLVYLDLSSNKLRSLPAELGNM 101
S +++SL + L +L L L++N L+ +P + L L LDL NKLR +P+ + +
Sbjct: 132 SNKLQSLPAEVGCLVNLMTLALSENSLTSLPDSLDNLKKLRMLDLRHNKLREIPSVVYRL 191
Query: 102 VSLRELLLNNNLLRVLPYELGRLFQLQTLGLKGNPLSQ 139
SL L L N + + ++ L +L L ++ N + Q
Sbjct: 192 DSLTTLYLRFNRITTVEKDIKNLSKLSMLSIRENKIKQ 229
>gi|157743290 leucine rich repeat containing 30 [Homo sapiens]
Length = 301
Score = 66.6 bits (161), Expect = 6e-11
Identities = 35/88 (39%), Positives = 53/88 (60%)
Query: 52 LWSLTHLTALHLNDNYLSRIPPDIAKLHNLVYLDLSSNKLRSLPAELGNMVSLRELLLNN 111
LW L+ + L+L+ N L +PP++ KL +V L+L N+L+SLP E+ + L+ L +N
Sbjct: 67 LWGLSEVQKLNLSHNQLRVLPPEVGKLTRIVVLNLCGNRLKSLPREVSLLQCLKVLFVNM 126
Query: 112 NLLRVLPYELGRLFQLQTLGLKGNPLSQ 139
N L +P EL +L+ L L N LSQ
Sbjct: 127 NCLTEVPAELSLCRKLEVLSLSHNCLSQ 154
Score = 46.6 bits (109), Expect = 6e-05
Identities = 35/108 (32%), Positives = 54/108 (50%), Gaps = 1/108 (0%)
Query: 31 GKKSHWAELEISG-RVRSLSTSLWSLTHLTALHLNDNYLSRIPPDIAKLHNLVYLDLSSN 89
GK + L + G R++SL + L L L +N N L+ +P +++ L L LS N
Sbjct: 91 GKLTRIVVLNLCGNRLKSLPREVSLLQCLKVLFVNMNCLTEVPAELSLCRKLEVLSLSHN 150
Query: 90 KLRSLPAELGNMVSLRELLLNNNLLRVLPYELGRLFQLQTLGLKGNPL 137
L LPA ++ LR+L L+NN +P + L +L L + N L
Sbjct: 151 CLSQLPACFADLSRLRKLNLSNNFFAHIPMCVFSLKELIFLHVGSNRL 198
Score = 46.6 bits (109), Expect = 6e-05
Identities = 37/118 (31%), Positives = 53/118 (44%), Gaps = 11/118 (9%)
Query: 52 LWSLTHLTALHLNDNYLSRIPPDIAKLHNLVYLDLSSNKLRSLPAELGNMVSLRELLLNN 111
++SL L LH+ N L I I L +L N + S P L + SL L LNN
Sbjct: 182 VFSLKELIFLHVGSNRLENIAESIQHLASLQIFIAEGNNIHSFPRSLCLVTSLELLNLNN 241
Query: 112 NLLRVLPYELGRLFQL---------QTLGLKGNPLSQDILNLYQDPDGTRKLLNFMLD 160
N ++ LP EL L +L + L + NPLS+ + L + G L ++ D
Sbjct: 242 NDIQTLPSELHLLCRLVRIAWNPMDKGLHISHNPLSKPLPELVE--GGLEMLFGYLKD 297
Score = 45.1 bits (105), Expect = 2e-04
Identities = 22/83 (26%), Positives = 44/83 (53%)
Query: 55 LTHLTALHLNDNYLSRIPPDIAKLHNLVYLDLSSNKLRSLPAELGNMVSLRELLLNNNLL 114
L+ L L+L++N+ + IP + L L++L + SN+L ++ + ++ SL+ + N +
Sbjct: 162 LSRLRKLNLSNNFFAHIPMCVFSLKELIFLHVGSNRLENIAESIQHLASLQIFIAEGNNI 221
Query: 115 RVLPYELGRLFQLQTLGLKGNPL 137
P L + L+ L L N +
Sbjct: 222 HSFPRSLCLVTSLELLNLNNNDI 244
Score = 41.6 bits (96), Expect = 0.002
Identities = 37/109 (33%), Positives = 55/109 (50%), Gaps = 4/109 (3%)
Query: 32 KKSHWAELEISGR-VRSLSTSLWSLTHLTALHLNDNYLSRIPPDIAKLHNLVYLDLSSNK 90
K S W + +SGR RSL L H + L ++ IP + L + L+LS N+
Sbjct: 26 KFSPWDDALLSGRDPRSL---LKRGMHHVSFSLVTRGMTDIPDFLWGLSEVQKLNLSHNQ 82
Query: 91 LRSLPAELGNMVSLRELLLNNNLLRVLPYELGRLFQLQTLGLKGNPLSQ 139
LR LP E+G + + L L N L+ LP E+ L L+ L + N L++
Sbjct: 83 LRVLPPEVGKLTRIVVLNLCGNRLKSLPREVSLLQCLKVLFVNMNCLTE 131
>gi|65301141 PH domain and leucine rich repeat protein
phosphatase-like [Homo sapiens]
Length = 1323
Score = 65.5 bits (158), Expect = 1e-10
Identities = 34/89 (38%), Positives = 53/89 (59%)
Query: 51 SLWSLTHLTALHLNDNYLSRIPPDIAKLHNLVYLDLSSNKLRSLPAELGNMVSLRELLLN 110
+L+ + L L+L+ N L P + ++ L L+LS N LP+++GN+++L+ L L+
Sbjct: 294 TLYKFSQLKGLNLSHNKLGLFPILLCEISTLTELNLSCNGFHDLPSQIGNLLNLQTLCLD 353
Query: 111 NNLLRVLPYELGRLFQLQTLGLKGNPLSQ 139
N L LP ELG L QL +LG+ N SQ
Sbjct: 354 GNFLTTLPEELGNLQQLSSLGISFNNFSQ 382
Score = 47.0 bits (110), Expect = 5e-05
Identities = 33/93 (35%), Positives = 48/93 (51%), Gaps = 2/93 (2%)
Query: 52 LWSLTHLTALHLNDNYLSRIPPDIAKLHNLVYLDLSSNKLRSLPAELGNMVSLRELLLNN 111
L ++ LT L+L+ N +P I L NL L L N L +LP ELGN+ L L ++
Sbjct: 318 LCEISTLTELNLSCNGFHDLPSQIGNLLNLQTLCLDGNFLTTLPEELGNLQQLSSLGISF 377
Query: 112 NLLRVLPYELGRLFQLQTLGLKGNPLSQDILNL 144
N +P +L L + + GN L ++LNL
Sbjct: 378 NNFSQIPEVYEKLTMLDRVVMAGNCL--EVLNL 408
Score = 41.2 bits (95), Expect = 0.003
Identities = 39/129 (30%), Positives = 66/129 (51%), Gaps = 12/129 (9%)
Query: 21 TIMSAEEVANGKKSHWAELEISG-RVRSLSTSLWSLTH---------LTALHLNDNYLSR 70
++ S E++ G+ + EL +SG +R+L S LT LT L L+ N L
Sbjct: 458 SLCSLEQLHCGR-NQLRELTLSGFSLRTLYASSNRLTAVNVYPVPSLLTFLDLSRNLLEC 516
Query: 71 IPPDIAKLHNLVYLDLSSNKLRSLPAELGNMVSLRELLLNNNLLRVLPYELGRLFQLQTL 130
+P + + LD+S N L +P + + +SLR+L+L +N ++ LP L L+ L
Sbjct: 517 VPDWACEAKKIEVLDVSYNLLTEVPVRILSSLSLRKLMLGHNHVQNLP-TLVEHIPLEVL 575
Query: 131 GLKGNPLSQ 139
L+ N L++
Sbjct: 576 DLQHNALTR 584
Score = 39.7 bits (91), Expect = 0.007
Identities = 33/86 (38%), Positives = 47/86 (54%), Gaps = 7/86 (8%)
Query: 58 LTALHLNDNYLSRIPPDI-AKLHNLVYLDLSSNKLRSLPAEL---GNMVSLRELLLNNNL 113
L L L N L+R+P + +K NL YL+ S+N L SLP+ ++ L+ L L NNL
Sbjct: 572 LEVLDLQHNALTRLPDTLFSKALNLRYLNASANSLESLPSACTGEESLSMLQLLYLTNNL 631
Query: 114 L--RVLPYELGRLFQLQTLGLKGNPL 137
L + +P +G L L+ L L N L
Sbjct: 632 LTDQCIPVLVGHL-HLRILHLANNQL 656
Score = 35.0 bits (79), Expect = 0.18
Identities = 29/102 (28%), Positives = 54/102 (52%), Gaps = 3/102 (2%)
Query: 38 ELEISG-RVRSLSTSLWSLTHLTALHLNDNYLSRIPPDIAKLHNLVYLDLSSNKLRSLPA 96
EL +SG +++++ T++ + L L + N +S I P+I +L + ++DLS N L +
Sbjct: 672 ELNLSGNKLKTIPTTIANCKRLHTLVAHSNNIS-IFPEILQLPQIQFVDLSCNDLTEILI 730
Query: 97 ELGNMVSLRELLLNNNLLRVLPYELGRLF-QLQTLGLKGNPL 137
+L++L L N VL ++ +F + TL + PL
Sbjct: 731 PEALPATLQDLDLTGNTNLVLEHKTLDIFSHITTLKIDQKPL 772
>gi|197333706 leucine rich repeat containing 8 family, member D
[Homo sapiens]
Length = 858
Score = 65.5 bits (158), Expect = 1e-10
Identities = 37/98 (37%), Positives = 58/98 (59%)
Query: 42 SGRVRSLSTSLWSLTHLTALHLNDNYLSRIPPDIAKLHNLVYLDLSSNKLRSLPAELGNM 101
+ ++ SL +++SL L L ++ N +S IP +I L NL +L ++ NK+ LP +L
Sbjct: 715 NNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKC 774
Query: 102 VSLRELLLNNNLLRVLPYELGRLFQLQTLGLKGNPLSQ 139
+ LR L L N + LP ++G+L QL L LKGN L +
Sbjct: 775 IKLRTLNLGQNCITSLPEKVGQLSQLTQLELKGNCLDR 812
Score = 57.0 bits (136), Expect = 4e-08
Identities = 42/112 (37%), Positives = 62/112 (55%), Gaps = 5/112 (4%)
Query: 34 SHWAELEI-SGRVRSLST--SLWSLTHLTALHLNDNYLSRIPPDIAKLHNLVYLDLSSNK 90
S+ EL++ S +R++ S L LT L L N + IPP I + NL L S+NK
Sbjct: 658 SNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNK 717
Query: 91 LRSLPAELGNMVSLRELLLNNNLLRVLPYELGRLFQLQTLGLKGNPLSQDIL 142
L SLP + ++ LR L ++ N + ++P E+G L LQ L + GN + DIL
Sbjct: 718 LESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKV--DIL 767
Score = 51.2 bits (121), Expect = 2e-06
Identities = 26/92 (28%), Positives = 53/92 (57%)
Query: 44 RVRSLSTSLWSLTHLTALHLNDNYLSRIPPDIAKLHNLVYLDLSSNKLRSLPAELGNMVS 103
++ ++ S+ + +L +L+ ++N L +P + L L LD+S N + +P E+G + +
Sbjct: 694 KIVTIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQN 753
Query: 104 LRELLLNNNLLRVLPYELGRLFQLQTLGLKGN 135
L+ L + N + +LP +L + +L+TL L N
Sbjct: 754 LQHLHITGNKVDILPKQLFKCIKLRTLNLGQN 785
Score = 37.7 bits (86), Expect = 0.028
Identities = 31/113 (27%), Positives = 48/113 (42%), Gaps = 25/113 (22%)
Query: 51 SLWSLTHLTALHLNDNYLSRIPPDIAKLHNLVYLDLSSNKLR------------------ 92
SL + ++ L L + L RIP I L NL LDL SN +R
Sbjct: 630 SLKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLK 689
Query: 93 -------SLPAELGNMVSLRELLLNNNLLRVLPYELGRLFQLQTLGLKGNPLS 138
++P + ++ +L L +NN L LP + L +L+ L + N +S
Sbjct: 690 LWHNKIVTIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNIS 742
>gi|34222199 leucine rich repeat containing 8 family, member D [Homo
sapiens]
Length = 858
Score = 65.5 bits (158), Expect = 1e-10
Identities = 37/98 (37%), Positives = 58/98 (59%)
Query: 42 SGRVRSLSTSLWSLTHLTALHLNDNYLSRIPPDIAKLHNLVYLDLSSNKLRSLPAELGNM 101
+ ++ SL +++SL L L ++ N +S IP +I L NL +L ++ NK+ LP +L
Sbjct: 715 NNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKC 774
Query: 102 VSLRELLLNNNLLRVLPYELGRLFQLQTLGLKGNPLSQ 139
+ LR L L N + LP ++G+L QL L LKGN L +
Sbjct: 775 IKLRTLNLGQNCITSLPEKVGQLSQLTQLELKGNCLDR 812
Score = 57.0 bits (136), Expect = 4e-08
Identities = 42/112 (37%), Positives = 62/112 (55%), Gaps = 5/112 (4%)
Query: 34 SHWAELEI-SGRVRSLST--SLWSLTHLTALHLNDNYLSRIPPDIAKLHNLVYLDLSSNK 90
S+ EL++ S +R++ S L LT L L N + IPP I + NL L S+NK
Sbjct: 658 SNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNK 717
Query: 91 LRSLPAELGNMVSLRELLLNNNLLRVLPYELGRLFQLQTLGLKGNPLSQDIL 142
L SLP + ++ LR L ++ N + ++P E+G L LQ L + GN + DIL
Sbjct: 718 LESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKV--DIL 767
Score = 51.2 bits (121), Expect = 2e-06
Identities = 26/92 (28%), Positives = 53/92 (57%)
Query: 44 RVRSLSTSLWSLTHLTALHLNDNYLSRIPPDIAKLHNLVYLDLSSNKLRSLPAELGNMVS 103
++ ++ S+ + +L +L+ ++N L +P + L L LD+S N + +P E+G + +
Sbjct: 694 KIVTIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQN 753
Query: 104 LRELLLNNNLLRVLPYELGRLFQLQTLGLKGN 135
L+ L + N + +LP +L + +L+TL L N
Sbjct: 754 LQHLHITGNKVDILPKQLFKCIKLRTLNLGQN 785
Score = 37.7 bits (86), Expect = 0.028
Identities = 31/113 (27%), Positives = 48/113 (42%), Gaps = 25/113 (22%)
Query: 51 SLWSLTHLTALHLNDNYLSRIPPDIAKLHNLVYLDLSSNKLR------------------ 92
SL + ++ L L + L RIP I L NL LDL SN +R
Sbjct: 630 SLKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLK 689
Query: 93 -------SLPAELGNMVSLRELLLNNNLLRVLPYELGRLFQLQTLGLKGNPLS 138
++P + ++ +L L +NN L LP + L +L+ L + N +S
Sbjct: 690 LWHNKIVTIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNIS 742
>gi|53729363 leucine rich repeat and sterile alpha motif containing
1 [Homo sapiens]
Length = 723
Score = 65.5 bits (158), Expect = 1e-10
Identities = 34/91 (37%), Positives = 54/91 (59%)
Query: 49 STSLWSLTHLTALHLNDNYLSRIPPDIAKLHNLVYLDLSSNKLRSLPAELGNMVSLRELL 108
S SL SL + L L+DN L+ +P D+ +L L L++ N+L LP +GN+ L+ L
Sbjct: 74 SCSLLSLATIKVLDLHDNQLTALPDDLGQLTALQVLNVERNQLMQLPRSIGNLTQLQTLN 133
Query: 109 LNNNLLRVLPYELGRLFQLQTLGLKGNPLSQ 139
+ +N L+ LP +G L L+TL + GN + +
Sbjct: 134 VKDNKLKELPDTVGELRSLRTLNISGNEIQR 164
Score = 51.6 bits (122), Expect = 2e-06
Identities = 41/145 (28%), Positives = 70/145 (48%), Gaps = 13/145 (8%)
Query: 44 RVRSLSTSLWSLTHLTALHLNDNYLSRIPPDIAKLHNLVYLDLSSNKLRSLPAELGNMVS 103
++ +L L LT L L++ N L ++P I L L L++ NKL+ LP +G + S
Sbjct: 92 QLTALPDDLGQLTALQVLNVERNQLMQLPRSIGNLTQLQTLNVKDNKLKELPDTVGELRS 151
Query: 104 LRELLLNNNLLRVLPYELGRLFQLQTLGLKGNPLSQDILNLYQDPD----GTRKLLNFML 159
LR L ++ N ++ LP L + L+ L L + + +Y + GT +L F+
Sbjct: 152 LRTLNISGNEIQRLPQMLAHVRTLEMLSLDASAM------VYPPREVCGAGTAAILQFLC 205
Query: 160 DNLAVHPEQLPPRPW-ITLKERDQI 183
+ E PP + + + E+D I
Sbjct: 206 KESGL--EYYPPSQYLLPILEQDGI 228
>gi|53729361 leucine rich repeat and sterile alpha motif containing
1 [Homo sapiens]
Length = 723
Score = 65.5 bits (158), Expect = 1e-10
Identities = 34/91 (37%), Positives = 54/91 (59%)
Query: 49 STSLWSLTHLTALHLNDNYLSRIPPDIAKLHNLVYLDLSSNKLRSLPAELGNMVSLRELL 108
S SL SL + L L+DN L+ +P D+ +L L L++ N+L LP +GN+ L+ L
Sbjct: 74 SCSLLSLATIKVLDLHDNQLTALPDDLGQLTALQVLNVERNQLMQLPRSIGNLTQLQTLN 133
Query: 109 LNNNLLRVLPYELGRLFQLQTLGLKGNPLSQ 139
+ +N L+ LP +G L L+TL + GN + +
Sbjct: 134 VKDNKLKELPDTVGELRSLRTLNISGNEIQR 164
Score = 51.6 bits (122), Expect = 2e-06
Identities = 41/145 (28%), Positives = 70/145 (48%), Gaps = 13/145 (8%)
Query: 44 RVRSLSTSLWSLTHLTALHLNDNYLSRIPPDIAKLHNLVYLDLSSNKLRSLPAELGNMVS 103
++ +L L LT L L++ N L ++P I L L L++ NKL+ LP +G + S
Sbjct: 92 QLTALPDDLGQLTALQVLNVERNQLMQLPRSIGNLTQLQTLNVKDNKLKELPDTVGELRS 151
Query: 104 LRELLLNNNLLRVLPYELGRLFQLQTLGLKGNPLSQDILNLYQDPD----GTRKLLNFML 159
LR L ++ N ++ LP L + L+ L L + + +Y + GT +L F+
Sbjct: 152 LRTLNISGNEIQRLPQMLAHVRTLEMLSLDASAM------VYPPREVCGAGTAAILQFLC 205
Query: 160 DNLAVHPEQLPPRPW-ITLKERDQI 183
+ E PP + + + E+D I
Sbjct: 206 KESGL--EYYPPSQYLLPILEQDGI 228
>gi|53729359 leucine rich repeat and sterile alpha motif containing
1 [Homo sapiens]
Length = 723
Score = 65.5 bits (158), Expect = 1e-10
Identities = 34/91 (37%), Positives = 54/91 (59%)
Query: 49 STSLWSLTHLTALHLNDNYLSRIPPDIAKLHNLVYLDLSSNKLRSLPAELGNMVSLRELL 108
S SL SL + L L+DN L+ +P D+ +L L L++ N+L LP +GN+ L+ L
Sbjct: 74 SCSLLSLATIKVLDLHDNQLTALPDDLGQLTALQVLNVERNQLMQLPRSIGNLTQLQTLN 133
Query: 109 LNNNLLRVLPYELGRLFQLQTLGLKGNPLSQ 139
+ +N L+ LP +G L L+TL + GN + +
Sbjct: 134 VKDNKLKELPDTVGELRSLRTLNISGNEIQR 164
Score = 51.6 bits (122), Expect = 2e-06
Identities = 41/145 (28%), Positives = 70/145 (48%), Gaps = 13/145 (8%)
Query: 44 RVRSLSTSLWSLTHLTALHLNDNYLSRIPPDIAKLHNLVYLDLSSNKLRSLPAELGNMVS 103
++ +L L LT L L++ N L ++P I L L L++ NKL+ LP +G + S
Sbjct: 92 QLTALPDDLGQLTALQVLNVERNQLMQLPRSIGNLTQLQTLNVKDNKLKELPDTVGELRS 151
Query: 104 LRELLLNNNLLRVLPYELGRLFQLQTLGLKGNPLSQDILNLYQDPD----GTRKLLNFML 159
LR L ++ N ++ LP L + L+ L L + + +Y + GT +L F+
Sbjct: 152 LRTLNISGNEIQRLPQMLAHVRTLEMLSLDASAM------VYPPREVCGAGTAAILQFLC 205
Query: 160 DNLAVHPEQLPPRPW-ITLKERDQI 183
+ E PP + + + E+D I
Sbjct: 206 KESGL--EYYPPSQYLLPILEQDGI 228
>gi|62241040 leucine rich repeat containing 8 family, member A [Homo
sapiens]
Length = 810
Score = 64.7 bits (156), Expect = 2e-10
Identities = 45/137 (32%), Positives = 68/137 (49%)
Query: 44 RVRSLSTSLWSLTHLTALHLNDNYLSRIPPDIAKLHNLVYLDLSSNKLRSLPAELGNMVS 103
++ + T L+ L L L+ N L+ +P DI L NL L +++N++ +LP EL
Sbjct: 673 KIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCRK 732
Query: 104 LRELLLNNNLLRVLPYELGRLFQLQTLGLKGNPLSQDILNLYQDPDGTRKLLNFMLDNLA 163
LR L L NN+L+ LP +G L L + L+GN L + L + P R L D
Sbjct: 733 LRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLLKRSGLVVEEDLFN 792
Query: 164 VHPEQLPPRPWITLKER 180
P ++ R W KE+
Sbjct: 793 TLPPEVKERLWRADKEQ 809
Score = 58.5 bits (140), Expect = 2e-08
Identities = 33/84 (39%), Positives = 49/84 (58%)
Query: 54 SLTHLTALHLNDNYLSRIPPDIAKLHNLVYLDLSSNKLRSLPAELGNMVSLRELLLNNNL 113
+LT+L L+LN N + +IP + L YLDLS N L LPA++G + +L+ L + N
Sbjct: 660 NLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANR 719
Query: 114 LRVLPYELGRLFQLQTLGLKGNPL 137
+ LP EL + +L+ L L N L
Sbjct: 720 IETLPPELFQCRKLRALHLGNNVL 743
Score = 52.4 bits (124), Expect = 1e-06
Identities = 28/82 (34%), Positives = 44/82 (53%), Gaps = 2/82 (2%)
Query: 42 SGRVRSLSTSLWSLTHLTALHLNDNYLSRIPPDIAKLHNLVYLDLSSNKLRSLPAELGNM 101
+ R+ +L L+ L ALHL +N L +P + +L NL ++L N+L LP ELG
Sbjct: 717 ANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGEC 776
Query: 102 VSLRE--LLLNNNLLRVLPYEL 121
L+ L++ +L LP E+
Sbjct: 777 PLLKRSGLVVEEDLFNTLPPEV 798
Score = 49.7 bits (117), Expect = 7e-06
Identities = 36/110 (32%), Positives = 57/110 (51%), Gaps = 3/110 (2%)
Query: 32 KKSHWAELE-ISGRVRSLSTSLWSLTHLTALHLNDNYLSRIPPDIA--KLHNLVYLDLSS 88
K ++ ELE I + + S++SL +L + L DN L I I+ LH L L L
Sbjct: 589 KMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWY 648
Query: 89 NKLRSLPAELGNMVSLRELLLNNNLLRVLPYELGRLFQLQTLGLKGNPLS 138
N + +P ++GN+ +L L LN N + +P +L +L+ L L N L+
Sbjct: 649 NHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLT 698
>gi|187829877 leucine rich repeat containing 8 family, member A
[Homo sapiens]
Length = 810
Score = 64.7 bits (156), Expect = 2e-10
Identities = 45/137 (32%), Positives = 68/137 (49%)
Query: 44 RVRSLSTSLWSLTHLTALHLNDNYLSRIPPDIAKLHNLVYLDLSSNKLRSLPAELGNMVS 103
++ + T L+ L L L+ N L+ +P DI L NL L +++N++ +LP EL
Sbjct: 673 KIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCRK 732
Query: 104 LRELLLNNNLLRVLPYELGRLFQLQTLGLKGNPLSQDILNLYQDPDGTRKLLNFMLDNLA 163
LR L L NN+L+ LP +G L L + L+GN L + L + P R L D
Sbjct: 733 LRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLLKRSGLVVEEDLFN 792
Query: 164 VHPEQLPPRPWITLKER 180
P ++ R W KE+
Sbjct: 793 TLPPEVKERLWRADKEQ 809
Score = 58.5 bits (140), Expect = 2e-08
Identities = 33/84 (39%), Positives = 49/84 (58%)
Query: 54 SLTHLTALHLNDNYLSRIPPDIAKLHNLVYLDLSSNKLRSLPAELGNMVSLRELLLNNNL 113
+LT+L L+LN N + +IP + L YLDLS N L LPA++G + +L+ L + N
Sbjct: 660 NLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANR 719
Query: 114 LRVLPYELGRLFQLQTLGLKGNPL 137
+ LP EL + +L+ L L N L
Sbjct: 720 IETLPPELFQCRKLRALHLGNNVL 743
Score = 52.4 bits (124), Expect = 1e-06
Identities = 28/82 (34%), Positives = 44/82 (53%), Gaps = 2/82 (2%)
Query: 42 SGRVRSLSTSLWSLTHLTALHLNDNYLSRIPPDIAKLHNLVYLDLSSNKLRSLPAELGNM 101
+ R+ +L L+ L ALHL +N L +P + +L NL ++L N+L LP ELG
Sbjct: 717 ANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGEC 776
Query: 102 VSLRE--LLLNNNLLRVLPYEL 121
L+ L++ +L LP E+
Sbjct: 777 PLLKRSGLVVEEDLFNTLPPEV 798
Score = 49.7 bits (117), Expect = 7e-06
Identities = 36/110 (32%), Positives = 57/110 (51%), Gaps = 3/110 (2%)
Query: 32 KKSHWAELE-ISGRVRSLSTSLWSLTHLTALHLNDNYLSRIPPDIA--KLHNLVYLDLSS 88
K ++ ELE I + + S++SL +L + L DN L I I+ LH L L L
Sbjct: 589 KMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWY 648
Query: 89 NKLRSLPAELGNMVSLRELLLNNNLLRVLPYELGRLFQLQTLGLKGNPLS 138
N + +P ++GN+ +L L LN N + +P +L +L+ L L N L+
Sbjct: 649 NHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLT 698
>gi|187829871 leucine rich repeat containing 8 family, member A
[Homo sapiens]
Length = 810
Score = 64.7 bits (156), Expect = 2e-10
Identities = 45/137 (32%), Positives = 68/137 (49%)
Query: 44 RVRSLSTSLWSLTHLTALHLNDNYLSRIPPDIAKLHNLVYLDLSSNKLRSLPAELGNMVS 103
++ + T L+ L L L+ N L+ +P DI L NL L +++N++ +LP EL
Sbjct: 673 KIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCRK 732
Query: 104 LRELLLNNNLLRVLPYELGRLFQLQTLGLKGNPLSQDILNLYQDPDGTRKLLNFMLDNLA 163
LR L L NN+L+ LP +G L L + L+GN L + L + P R L D
Sbjct: 733 LRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLLKRSGLVVEEDLFN 792
Query: 164 VHPEQLPPRPWITLKER 180
P ++ R W KE+
Sbjct: 793 TLPPEVKERLWRADKEQ 809
Score = 58.5 bits (140), Expect = 2e-08
Identities = 33/84 (39%), Positives = 49/84 (58%)
Query: 54 SLTHLTALHLNDNYLSRIPPDIAKLHNLVYLDLSSNKLRSLPAELGNMVSLRELLLNNNL 113
+LT+L L+LN N + +IP + L YLDLS N L LPA++G + +L+ L + N
Sbjct: 660 NLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANR 719
Query: 114 LRVLPYELGRLFQLQTLGLKGNPL 137
+ LP EL + +L+ L L N L
Sbjct: 720 IETLPPELFQCRKLRALHLGNNVL 743
Score = 52.4 bits (124), Expect = 1e-06
Identities = 28/82 (34%), Positives = 44/82 (53%), Gaps = 2/82 (2%)
Query: 42 SGRVRSLSTSLWSLTHLTALHLNDNYLSRIPPDIAKLHNLVYLDLSSNKLRSLPAELGNM 101
+ R+ +L L+ L ALHL +N L +P + +L NL ++L N+L LP ELG
Sbjct: 717 ANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGEC 776
Query: 102 VSLRE--LLLNNNLLRVLPYEL 121
L+ L++ +L LP E+
Sbjct: 777 PLLKRSGLVVEEDLFNTLPPEV 798
Score = 49.7 bits (117), Expect = 7e-06
Identities = 36/110 (32%), Positives = 57/110 (51%), Gaps = 3/110 (2%)
Query: 32 KKSHWAELE-ISGRVRSLSTSLWSLTHLTALHLNDNYLSRIPPDIA--KLHNLVYLDLSS 88
K ++ ELE I + + S++SL +L + L DN L I I+ LH L L L
Sbjct: 589 KMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWY 648
Query: 89 NKLRSLPAELGNMVSLRELLLNNNLLRVLPYELGRLFQLQTLGLKGNPLS 138
N + +P ++GN+ +L L LN N + +P +L +L+ L L N L+
Sbjct: 649 NHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLT 698
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.137 0.414
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,427,461
Number of Sequences: 37866
Number of extensions: 1006953
Number of successful extensions: 3127
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 124
Number of HSP's successfully gapped in prelim test: 101
Number of HSP's that attempted gapping in prelim test: 2237
Number of HSP's gapped (non-prelim): 771
length of query: 555
length of database: 18,247,518
effective HSP length: 107
effective length of query: 448
effective length of database: 14,195,856
effective search space: 6359743488
effective search space used: 6359743488
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.