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Search of human proteins with 115529463
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|115529463 protein kinase D1 [Homo sapiens]
(912 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|115529463 protein kinase D1 [Homo sapiens] 1855 0.0
gi|5031689 protein kinase D3 [Homo sapiens] 1232 0.0
gi|120659785 protein kinase D2 isoform A [Homo sapiens] 1213 0.0
gi|120659782 protein kinase D2 isoform A [Homo sapiens] 1213 0.0
gi|19923468 protein kinase D2 isoform A [Homo sapiens] 1213 0.0
gi|120659787 protein kinase D2 isoform B [Homo sapiens] 1011 0.0
gi|54112407 protein kinase CHK2 isoform c [Homo sapiens] 191 3e-48
gi|6005850 protein kinase CHK2 isoform a [Homo sapiens] 191 3e-48
gi|149589021 doublecortin-like kinase 3 [Homo sapiens] 183 6e-46
gi|9966875 calcium/calmodulin-dependent protein kinase ID isofor... 177 3e-44
gi|23943850 calcium/calmodulin-dependent protein kinase ID isofo... 177 3e-44
gi|14196445 calcium/calmodulin-dependent protein kinase IG [Homo... 172 2e-42
gi|156713430 doublecortin-like kinase 2 isoform b [Homo sapiens] 171 2e-42
gi|156713428 doublecortin-like kinase 2 isoform a [Homo sapiens] 171 2e-42
gi|4502553 calcium/calmodulin-dependent protein kinase I [Homo s... 170 6e-42
gi|4502557 calcium/calmodulin-dependent protein kinase IV [Homo ... 167 4e-41
gi|209364621 pregnancy upregulated non-ubiquitously expressed Ca... 162 2e-39
gi|209364619 pregnancy upregulated non-ubiquitously expressed Ca... 162 2e-39
gi|212549756 calcium/calmodulin-dependent protein kinase II delt... 160 4e-39
gi|26667183 calcium/calmodulin-dependent protein kinase II delta... 160 4e-39
gi|212549753 calcium/calmodulin-dependent protein kinase II delt... 160 4e-39
gi|26667186 calcium/calmodulin-dependent protein kinase II delta... 160 4e-39
gi|26667189 calcium/calmodulin-dependent protein kinase II delta... 160 4e-39
gi|26667180 calcium/calmodulin-dependent protein kinase II delta... 160 4e-39
gi|27901803 protein serine kinase H1 [Homo sapiens] 157 4e-38
gi|109255245 serine/threonine kinase 17a [Homo sapiens] 157 6e-38
gi|26667199 calcium/calmodulin-dependent protein kinase II gamma... 155 1e-37
gi|25952118 calcium/calmodulin-dependent protein kinase II alpha... 155 1e-37
gi|25952114 calcium/calmodulin-dependent protein kinase II alpha... 155 1e-37
gi|26667191 calcium/calmodulin-dependent protein kinase II gamma... 155 1e-37
>gi|115529463 protein kinase D1 [Homo sapiens]
Length = 912
Score = 1855 bits (4804), Expect = 0.0
Identities = 912/912 (100%), Positives = 912/912 (100%)
Query: 1 MSAPPVLRPPSPLLPVAAAAAAAAAALVPGSGPGPAPFLAPVAAPVGGISFHLQIGLSRE 60
MSAPPVLRPPSPLLPVAAAAAAAAAALVPGSGPGPAPFLAPVAAPVGGISFHLQIGLSRE
Sbjct: 1 MSAPPVLRPPSPLLPVAAAAAAAAAALVPGSGPGPAPFLAPVAAPVGGISFHLQIGLSRE 60
Query: 61 PVLLLQDSSGDYSLAHVREMACSIVDQKFPECGFYGMYDKILLFRHDPTSENILQLVKAA 120
PVLLLQDSSGDYSLAHVREMACSIVDQKFPECGFYGMYDKILLFRHDPTSENILQLVKAA
Sbjct: 61 PVLLLQDSSGDYSLAHVREMACSIVDQKFPECGFYGMYDKILLFRHDPTSENILQLVKAA 120
Query: 121 SDIQEGDLIEVVLSASATFEDFQIRPHALFVHSYRAPAFCDHCGEMLWGLVRQGLKCEGC 180
SDIQEGDLIEVVLSASATFEDFQIRPHALFVHSYRAPAFCDHCGEMLWGLVRQGLKCEGC
Sbjct: 121 SDIQEGDLIEVVLSASATFEDFQIRPHALFVHSYRAPAFCDHCGEMLWGLVRQGLKCEGC 180
Query: 181 GLNYHKRCAFKIPNNCSGVRRRRLSNVSLTGVSTIRTSSAELSTSAPDEPLLQKSPSESF 240
GLNYHKRCAFKIPNNCSGVRRRRLSNVSLTGVSTIRTSSAELSTSAPDEPLLQKSPSESF
Sbjct: 181 GLNYHKRCAFKIPNNCSGVRRRRLSNVSLTGVSTIRTSSAELSTSAPDEPLLQKSPSESF 240
Query: 241 IGREKRSNSQSYIGRPIHLDKILMSKVKVPHTFVIHSYTRPTVCQYCKKLLKGLFRQGLQ 300
IGREKRSNSQSYIGRPIHLDKILMSKVKVPHTFVIHSYTRPTVCQYCKKLLKGLFRQGLQ
Sbjct: 241 IGREKRSNSQSYIGRPIHLDKILMSKVKVPHTFVIHSYTRPTVCQYCKKLLKGLFRQGLQ 300
Query: 301 CKDCRFNCHKRCAPKVPNNCLGEVTINGDLLSPGAESDVVMEEGSDDNDSERNSGLMDDM 360
CKDCRFNCHKRCAPKVPNNCLGEVTINGDLLSPGAESDVVMEEGSDDNDSERNSGLMDDM
Sbjct: 301 CKDCRFNCHKRCAPKVPNNCLGEVTINGDLLSPGAESDVVMEEGSDDNDSERNSGLMDDM 360
Query: 361 EEAMVQDAEMAMAECQNDSGEMQDPDPDHEDANRTISPSTSNNIPLMRVVQSVKHTKRKS 420
EEAMVQDAEMAMAECQNDSGEMQDPDPDHEDANRTISPSTSNNIPLMRVVQSVKHTKRKS
Sbjct: 361 EEAMVQDAEMAMAECQNDSGEMQDPDPDHEDANRTISPSTSNNIPLMRVVQSVKHTKRKS 420
Query: 421 STVMKEGWMVHYTSKDTLRKRHYWRLDSKCITLFQNDTGSRYYKEIPLSEILSLEPVKTS 480
STVMKEGWMVHYTSKDTLRKRHYWRLDSKCITLFQNDTGSRYYKEIPLSEILSLEPVKTS
Sbjct: 421 STVMKEGWMVHYTSKDTLRKRHYWRLDSKCITLFQNDTGSRYYKEIPLSEILSLEPVKTS 480
Query: 481 ALIPNGANPHCFEITTANVVYYVGENVVNPSSPSPNNSVLTSGVGADVARMWEIAIQHAL 540
ALIPNGANPHCFEITTANVVYYVGENVVNPSSPSPNNSVLTSGVGADVARMWEIAIQHAL
Sbjct: 481 ALIPNGANPHCFEITTANVVYYVGENVVNPSSPSPNNSVLTSGVGADVARMWEIAIQHAL 540
Query: 541 MPVIPKGSSVGTGTNLHRDISVSISVSNCQIQENVDISTVYQIFPDEVLGSGQFGIVYGG 600
MPVIPKGSSVGTGTNLHRDISVSISVSNCQIQENVDISTVYQIFPDEVLGSGQFGIVYGG
Sbjct: 541 MPVIPKGSSVGTGTNLHRDISVSISVSNCQIQENVDISTVYQIFPDEVLGSGQFGIVYGG 600
Query: 601 KHRKTGRDVAIKIIDKLRFPTKQESQLRNEVAILQNLHHPGVVNLECMFETPERVFVVME 660
KHRKTGRDVAIKIIDKLRFPTKQESQLRNEVAILQNLHHPGVVNLECMFETPERVFVVME
Sbjct: 601 KHRKTGRDVAIKIIDKLRFPTKQESQLRNEVAILQNLHHPGVVNLECMFETPERVFVVME 660
Query: 661 KLHGDMLEMILSSEKGRLPEHITKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPF 720
KLHGDMLEMILSSEKGRLPEHITKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPF
Sbjct: 661 KLHGDMLEMILSSEKGRLPEHITKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPF 720
Query: 721 PQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRNKGYNRSLDMWSVGVIIYVSLSGT 780
PQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRNKGYNRSLDMWSVGVIIYVSLSGT
Sbjct: 721 PQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRNKGYNRSLDMWSVGVIIYVSLSGT 780
Query: 781 FPFNEDEDIHDQIQNAAFMYPPNPWKEISHEAIDLINNLLQVKMRKRYSVDKTLSHPWLQ 840
FPFNEDEDIHDQIQNAAFMYPPNPWKEISHEAIDLINNLLQVKMRKRYSVDKTLSHPWLQ
Sbjct: 781 FPFNEDEDIHDQIQNAAFMYPPNPWKEISHEAIDLINNLLQVKMRKRYSVDKTLSHPWLQ 840
Query: 841 DYQTWLDLRELECKIGERYITHESDDLRWEKYAGEQGLQYPTHLINPSASHSDTPETEET 900
DYQTWLDLRELECKIGERYITHESDDLRWEKYAGEQGLQYPTHLINPSASHSDTPETEET
Sbjct: 841 DYQTWLDLRELECKIGERYITHESDDLRWEKYAGEQGLQYPTHLINPSASHSDTPETEET 900
Query: 901 EMKALGERVSIL 912
EMKALGERVSIL
Sbjct: 901 EMKALGERVSIL 912
>gi|5031689 protein kinase D3 [Homo sapiens]
Length = 890
Score = 1232 bits (3188), Expect = 0.0
Identities = 626/891 (70%), Positives = 715/891 (80%), Gaps = 33/891 (3%)
Query: 13 LLPVAAAAAAAAAALVP--GSGPGPAPFLAPVAAPVGGISFHLQIGLSREPVLLLQDSSG 70
+LP A+ ++ L +G AP L V +SF LQIGL+RE V + +
Sbjct: 22 VLPAASPCSSPKTGLSARLSNGSFSAPSLTNSRGSVHTVSFLLQIGLTRESVTI---EAQ 78
Query: 71 DYSLAHVREMACSIVDQKFPECGFYGMYDKILLFRHDPTSENILQLVKAASDIQEGDLIE 130
+ SL+ V+++ CSIV QKFPECGF+GMYDKILLFRHD SENILQL+ +A +I EGDL+E
Sbjct: 79 ELSLSAVKDLVCSIVYQKFPECGFFGMYDKILLFRHDMNSENILQLITSADEIHEGDLVE 138
Query: 131 VVLSASATFEDFQIRPHALFVHSYRAPAFCDHCGEMLWGLVRQGLKCEGCGLNYHKRCAF 190
VVLSA AT EDFQIRPH L+VHSY+AP FCD+CGEMLWGLVRQGLKCEGCGLNYHKRCAF
Sbjct: 139 VVLSALATVEDFQIRPHTLYVHSYKAPTFCDYCGEMLWGLVRQGLKCEGCGLNYHKRCAF 198
Query: 191 KIPNNCSGVRRRRLSNVSLTGVSTIRTSSAELSTSAPDEPLLQKSPSE-SFIGREKRSNS 249
KIPNNCSGVR+RRLSNVSL G LS P +P PSE S + +E
Sbjct: 199 KIPNNCSGVRKRRLSNVSLPGPG--------LSVPRPLQPEYVALPSEESHVHQEPSKRI 250
Query: 250 QSYIGRPIHLDKILMSKVKVPHTFVIHSYTRPTVCQYCKKLLKGLFRQGLQCKDCRFNCH 309
S+ GRPI ++K++M +VKVPHTF +HSYTRPT+CQYCK+LLKGLFRQG+QCKDC+FNCH
Sbjct: 251 PSWSGRPIWMEKMVMCRVKVPHTFAVHSYTRPTICQYCKRLLKGLFRQGMQCKDCKFNCH 310
Query: 310 KRCAPKVPNNCLGEVTINGDLLSPGAESDVVMEEGSDDNDSERNSGLMDDMEEAMVQDAE 369
KRCA KVP +CLGEVT NG+ S G ++D+ M+ ++D +S+ + GL DD EE + +
Sbjct: 311 KRCASKVPRDCLGEVTFNGEPSSLGTDTDIPMDIDNNDINSDSSRGL-DDTEEPSPPEDK 369
Query: 370 MAMAECQNDSGEMQDPDPDHEDANRTISPSTSNNIPLMRVVQSVKHTKRKSSTVMKEGWM 429
M + + E E+A +TISPSTSNNIPLMRVVQS+KHTKRKSST++KEGWM
Sbjct: 370 MFFLDPSDLDVERD------EEAVKTISPSTSNNIPLMRVVQSIKHTKRKSSTMVKEGWM 423
Query: 430 VHYTSKDTLRKRHYWRLDSKCITLFQNDTGSRYYKEIPLSEILSLEPVKTSALIPNGANP 489
VHYTS+D LRKRHYWRLDSKC+TLFQN++GS+YYKEIPLSEIL + + I G+NP
Sbjct: 424 VHYTSRDNLRKRHYWRLDSKCLTLFQNESGSKYYKEIPLSEILRISSPRDFTNISQGSNP 483
Query: 490 HCFEITTANVVYYVGENVVNPSSPSPNNSVLTS-GVGADVARMWEIAIQHALMPVIPKGS 548
HCFEI T +VY+VGEN + S +N VL + GVG DVA+ WE AI+ ALMPV P+ S
Sbjct: 484 HCFEIITDTMVYFVGEN----NGDSSHNPVLAATGVGLDVAQSWEKAIRQALMPVTPQAS 539
Query: 549 ---SVGTGTNLHRDISVSISVSNCQIQENVDISTVYQIFPDEVLGSGQFGIVYGGKHRKT 605
S G G + H+D+S SISVSNCQIQENVDISTVYQIF DEVLGSGQFGIVYGGKHRKT
Sbjct: 540 VCTSPGQGKD-HKDLSTSISVSNCQIQENVDISTVYQIFADEVLGSGQFGIVYGGKHRKT 598
Query: 606 GRDVAIKIIDKLRFPTKQESQLRNEVAILQNLHHPGVVNLECMFETPERVFVVMEKLHGD 665
GRDVAIK+IDK+RFPTKQESQLRNEVAILQNLHHPG+VNLECMFETPERVFVVMEKLHGD
Sbjct: 599 GRDVAIKVIDKMRFPTKQESQLRNEVAILQNLHHPGIVNLECMFETPERVFVVMEKLHGD 658
Query: 666 MLEMILSSEKGRLPEHITKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPFPQVKL 725
MLEMILSSEK RLPE ITKF++TQILVALR+LHFKNIVHCDLKPENVLLASA+PFPQVKL
Sbjct: 659 MLEMILSSEKSRLPERITKFMVTQILVALRNLHFKNIVHCDLKPENVLLASAEPFPQVKL 718
Query: 726 CDFGFARIIGEKSFRRSVVGTPAYLAPEVLRNKGYNRSLDMWSVGVIIYVSLSGTFPFNE 785
CDFGFARIIGEKSFRRSVVGTPAYLAPEVLR+KGYNRSLDMWSVGVIIYVSLSGTFPFNE
Sbjct: 719 CDFGFARIIGEKSFRRSVVGTPAYLAPEVLRSKGYNRSLDMWSVGVIIYVSLSGTFPFNE 778
Query: 786 DEDIHDQIQNAAFMYPPNPWKEISHEAIDLINNLLQVKMRKRYSVDKTLSHPWLQDYQTW 845
DEDI+DQIQNAAFMYPPNPW+EIS EAIDLINNLLQVKMRKRYSVDK+LSHPWLQDYQTW
Sbjct: 779 DEDINDQIQNAAFMYPPNPWREISGEAIDLINNLLQVKMRKRYSVDKSLSHPWLQDYQTW 838
Query: 846 LDLRELECKIGERYITHESDDLRWEKYAGEQGLQYPTHLI---NPSASHSD 893
LDLRE E +IGERYITHESDD RWE +A L YP H I NP D
Sbjct: 839 LDLREFETRIGERYITHESDDARWEIHAYTHNLVYPKHFIMAPNPDDMEED 889
>gi|120659785 protein kinase D2 isoform A [Homo sapiens]
Length = 878
Score = 1213 bits (3139), Expect = 0.0
Identities = 626/918 (68%), Positives = 718/918 (78%), Gaps = 65/918 (7%)
Query: 19 AAAAAAAALVPGS-GPG------------PAPFLAPVAAPVGGISFHLQIGLSREPVLLL 65
A A + A +PGS GPG P P L + AP G+SFH+QIGL+RE VLL
Sbjct: 2 ATAPSYPAGLPGSPGPGSPPPPGGLELQSPPPLLPQIPAPGSGVSFHIQIGLTREFVLLP 61
Query: 66 QDSSGDYSLAHVREMACSIVDQKFPECGFYGMYDKILLFRHDPTSENILQLVKAASDIQE 125
S LAHV+++ACSIVDQKFPECGFYG+YDKILLF+HDPTS N+LQLV+++ DIQE
Sbjct: 62 AASE----LAHVKQLACSIVDQKFPECGFYGLYDKILLFKHDPTSANLLQLVRSSGDIQE 117
Query: 126 GDLIEVVLSASATFEDFQIRPHALFVHSYRAPAFCDHCGEMLWGLVRQGLKCEGCGLNYH 185
GDL+EVVLSASATFEDFQIRPHAL VHSYRAPAFCDHCGEML+GLVRQGLKC+GCGLNYH
Sbjct: 118 GDLVEVVLSASATFEDFQIRPHALTVHSYRAPAFCDHCGEMLFGLVRQGLKCDGCGLNYH 177
Query: 186 KRCAFKIPNNCSGVRRRRLSNVSLTGVSTIRTSSAELSTSAPDEPLLQKSPSESFIGREK 245
KRCAF IPNNCSG R+RRLS+ SL ++R ++E +E L +S +E R
Sbjct: 178 KRCAFSIPNNCSGARKRRLSSTSLASGHSVRLGTSESLPCTAEE--LSRSTTELLPRRPP 235
Query: 246 RSNSQS----YIGRPIHLDKILMSKVKVPHTFVIHSYTRPTVCQYCKKLLKGLFRQGLQC 301
S+S S Y GRPI LDK+L+SKVKVPHTF+IHSYTRPTVCQ CKKLLKGLFRQGLQC
Sbjct: 236 SSSSSSSASSYTGRPIELDKMLLSKVKVPHTFLIHSYTRPTVCQACKKLLKGLFRQGLQC 295
Query: 302 KDCRFNCHKRCAPKVPNNCLGEVTINGDLLSPGAESDVVMEEGSDDNDSERNSGLMDDME 361
KDC+FNCHKRCA +VPN+CLGE INGD V MEE +D +++++ S LMD+ E
Sbjct: 296 KDCKFNCHKRCATRVPNDCLGEALINGD---------VPMEEATDFSEADK-SALMDESE 345
Query: 362 EAMV------QDAEMAMAECQNDSGEMQDPDPDHEDANRTISPSTSNNIPLMRVVQSVKH 415
++ V ++A A E + + G+ Q S+ IPLMRVVQSV+H
Sbjct: 346 DSGVIPGSHSENALHASEEEEGEGGKAQ---------------SSLGYIPLMRVVQSVRH 390
Query: 416 TKRKSSTVMKEGWMVHYTSKDTLRKRHYWRLDSKCITLFQNDTGSRYYKEIPLSEILSLE 475
T RKSST ++EGW+VHY++KDTLRKRHYWRLD KCITLFQN+T +RYYKEIPLSEIL++E
Sbjct: 391 TTRKSSTTLREGWVVHYSNKDTLRKRHYWRLDCKCITLFQNNTTNRYYKEIPLSEILTVE 450
Query: 476 PVKTSALIPNGANPHCFEITTANVVYYVGENVVN-PSSPSPNNSVLTSGVGADVARMWEI 534
+ +L+P G NPHCFEI TAN Y+VGE P PS G GA+ AR WE
Sbjct: 451 SAQNFSLVPPGTNPHCFEIVTANATYFVGEMPGGTPGGPS--------GQGAEAARGWET 502
Query: 535 AIQHALMPVIPKGSSVGTGTNLHRDISVSISVSNCQIQENVDISTVYQIFPDEVLGSGQF 594
AI+ ALMPVI + + G HR S+SISVSN QIQENVDI+TVYQIFPDEVLGSGQF
Sbjct: 503 AIRQALMPVILQDAPSAPGHAPHRQASLSISVSNSQIQENVDIATVYQIFPDEVLGSGQF 562
Query: 595 GIVYGGKHRKTGRDVAIKIIDKLRFPTKQESQLRNEVAILQNLHHPGVVNLECMFETPER 654
G+VYGGKHRKTGRDVA+K+IDKLRFPTKQESQLRNEVAILQ+L HPG+VNLECMFETPE+
Sbjct: 563 GVVYGGKHRKTGRDVAVKVIDKLRFPTKQESQLRNEVAILQSLRHPGIVNLECMFETPEK 622
Query: 655 VFVVMEKLHGDMLEMILSSEKGRLPEHITKFLITQILVALRHLHFKNIVHCDLKPENVLL 714
VFVVMEKLHGDMLEMILSSEKGRLPE +TKFLITQILVALRHLHFKNIVHCDLKPENVLL
Sbjct: 623 VFVVMEKLHGDMLEMILSSEKGRLPERLTKFLITQILVALRHLHFKNIVHCDLKPENVLL 682
Query: 715 ASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRNKGYNRSLDMWSVGVIIY 774
ASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVL N+GYNRSLDMWSVGVI+Y
Sbjct: 683 ASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLLNQGYNRSLDMWSVGVIMY 742
Query: 775 VSLSGTFPFNEDEDIHDQIQNAAFMYPPNPWKEISHEAIDLINNLLQVKMRKRYSVDKTL 834
VSLSGTFPFNEDEDI+DQIQNAAFMYP +PW IS AIDLINNLLQVKMRKRYSVDK+L
Sbjct: 743 VSLSGTFPFNEDEDINDQIQNAAFMYPASPWSHISAGAIDLINNLLQVKMRKRYSVDKSL 802
Query: 835 SHPWLQDYQTWLDLRELECKIGERYITHESDDLRWEKYAGEQGLQYPTHLINPSASHSDT 894
SHPWLQ+YQTWLDLRELE K+GERYITHESDD RWE++A E L P +
Sbjct: 803 SHPWLQEYQTWLDLRELEGKMGERYITHESDDARWEQFAAEHPL--PGSGLPTDRDLGGA 860
Query: 895 PETEETEMKALGERVSIL 912
++ +M+ L ER+S+L
Sbjct: 861 CPPQDHDMQGLAERISVL 878
>gi|120659782 protein kinase D2 isoform A [Homo sapiens]
Length = 878
Score = 1213 bits (3139), Expect = 0.0
Identities = 626/918 (68%), Positives = 718/918 (78%), Gaps = 65/918 (7%)
Query: 19 AAAAAAAALVPGS-GPG------------PAPFLAPVAAPVGGISFHLQIGLSREPVLLL 65
A A + A +PGS GPG P P L + AP G+SFH+QIGL+RE VLL
Sbjct: 2 ATAPSYPAGLPGSPGPGSPPPPGGLELQSPPPLLPQIPAPGSGVSFHIQIGLTREFVLLP 61
Query: 66 QDSSGDYSLAHVREMACSIVDQKFPECGFYGMYDKILLFRHDPTSENILQLVKAASDIQE 125
S LAHV+++ACSIVDQKFPECGFYG+YDKILLF+HDPTS N+LQLV+++ DIQE
Sbjct: 62 AASE----LAHVKQLACSIVDQKFPECGFYGLYDKILLFKHDPTSANLLQLVRSSGDIQE 117
Query: 126 GDLIEVVLSASATFEDFQIRPHALFVHSYRAPAFCDHCGEMLWGLVRQGLKCEGCGLNYH 185
GDL+EVVLSASATFEDFQIRPHAL VHSYRAPAFCDHCGEML+GLVRQGLKC+GCGLNYH
Sbjct: 118 GDLVEVVLSASATFEDFQIRPHALTVHSYRAPAFCDHCGEMLFGLVRQGLKCDGCGLNYH 177
Query: 186 KRCAFKIPNNCSGVRRRRLSNVSLTGVSTIRTSSAELSTSAPDEPLLQKSPSESFIGREK 245
KRCAF IPNNCSG R+RRLS+ SL ++R ++E +E L +S +E R
Sbjct: 178 KRCAFSIPNNCSGARKRRLSSTSLASGHSVRLGTSESLPCTAEE--LSRSTTELLPRRPP 235
Query: 246 RSNSQS----YIGRPIHLDKILMSKVKVPHTFVIHSYTRPTVCQYCKKLLKGLFRQGLQC 301
S+S S Y GRPI LDK+L+SKVKVPHTF+IHSYTRPTVCQ CKKLLKGLFRQGLQC
Sbjct: 236 SSSSSSSASSYTGRPIELDKMLLSKVKVPHTFLIHSYTRPTVCQACKKLLKGLFRQGLQC 295
Query: 302 KDCRFNCHKRCAPKVPNNCLGEVTINGDLLSPGAESDVVMEEGSDDNDSERNSGLMDDME 361
KDC+FNCHKRCA +VPN+CLGE INGD V MEE +D +++++ S LMD+ E
Sbjct: 296 KDCKFNCHKRCATRVPNDCLGEALINGD---------VPMEEATDFSEADK-SALMDESE 345
Query: 362 EAMV------QDAEMAMAECQNDSGEMQDPDPDHEDANRTISPSTSNNIPLMRVVQSVKH 415
++ V ++A A E + + G+ Q S+ IPLMRVVQSV+H
Sbjct: 346 DSGVIPGSHSENALHASEEEEGEGGKAQ---------------SSLGYIPLMRVVQSVRH 390
Query: 416 TKRKSSTVMKEGWMVHYTSKDTLRKRHYWRLDSKCITLFQNDTGSRYYKEIPLSEILSLE 475
T RKSST ++EGW+VHY++KDTLRKRHYWRLD KCITLFQN+T +RYYKEIPLSEIL++E
Sbjct: 391 TTRKSSTTLREGWVVHYSNKDTLRKRHYWRLDCKCITLFQNNTTNRYYKEIPLSEILTVE 450
Query: 476 PVKTSALIPNGANPHCFEITTANVVYYVGENVVN-PSSPSPNNSVLTSGVGADVARMWEI 534
+ +L+P G NPHCFEI TAN Y+VGE P PS G GA+ AR WE
Sbjct: 451 SAQNFSLVPPGTNPHCFEIVTANATYFVGEMPGGTPGGPS--------GQGAEAARGWET 502
Query: 535 AIQHALMPVIPKGSSVGTGTNLHRDISVSISVSNCQIQENVDISTVYQIFPDEVLGSGQF 594
AI+ ALMPVI + + G HR S+SISVSN QIQENVDI+TVYQIFPDEVLGSGQF
Sbjct: 503 AIRQALMPVILQDAPSAPGHAPHRQASLSISVSNSQIQENVDIATVYQIFPDEVLGSGQF 562
Query: 595 GIVYGGKHRKTGRDVAIKIIDKLRFPTKQESQLRNEVAILQNLHHPGVVNLECMFETPER 654
G+VYGGKHRKTGRDVA+K+IDKLRFPTKQESQLRNEVAILQ+L HPG+VNLECMFETPE+
Sbjct: 563 GVVYGGKHRKTGRDVAVKVIDKLRFPTKQESQLRNEVAILQSLRHPGIVNLECMFETPEK 622
Query: 655 VFVVMEKLHGDMLEMILSSEKGRLPEHITKFLITQILVALRHLHFKNIVHCDLKPENVLL 714
VFVVMEKLHGDMLEMILSSEKGRLPE +TKFLITQILVALRHLHFKNIVHCDLKPENVLL
Sbjct: 623 VFVVMEKLHGDMLEMILSSEKGRLPERLTKFLITQILVALRHLHFKNIVHCDLKPENVLL 682
Query: 715 ASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRNKGYNRSLDMWSVGVIIY 774
ASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVL N+GYNRSLDMWSVGVI+Y
Sbjct: 683 ASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLLNQGYNRSLDMWSVGVIMY 742
Query: 775 VSLSGTFPFNEDEDIHDQIQNAAFMYPPNPWKEISHEAIDLINNLLQVKMRKRYSVDKTL 834
VSLSGTFPFNEDEDI+DQIQNAAFMYP +PW IS AIDLINNLLQVKMRKRYSVDK+L
Sbjct: 743 VSLSGTFPFNEDEDINDQIQNAAFMYPASPWSHISAGAIDLINNLLQVKMRKRYSVDKSL 802
Query: 835 SHPWLQDYQTWLDLRELECKIGERYITHESDDLRWEKYAGEQGLQYPTHLINPSASHSDT 894
SHPWLQ+YQTWLDLRELE K+GERYITHESDD RWE++A E L P +
Sbjct: 803 SHPWLQEYQTWLDLRELEGKMGERYITHESDDARWEQFAAEHPL--PGSGLPTDRDLGGA 860
Query: 895 PETEETEMKALGERVSIL 912
++ +M+ L ER+S+L
Sbjct: 861 CPPQDHDMQGLAERISVL 878
>gi|19923468 protein kinase D2 isoform A [Homo sapiens]
Length = 878
Score = 1213 bits (3139), Expect = 0.0
Identities = 626/918 (68%), Positives = 718/918 (78%), Gaps = 65/918 (7%)
Query: 19 AAAAAAAALVPGS-GPG------------PAPFLAPVAAPVGGISFHLQIGLSREPVLLL 65
A A + A +PGS GPG P P L + AP G+SFH+QIGL+RE VLL
Sbjct: 2 ATAPSYPAGLPGSPGPGSPPPPGGLELQSPPPLLPQIPAPGSGVSFHIQIGLTREFVLLP 61
Query: 66 QDSSGDYSLAHVREMACSIVDQKFPECGFYGMYDKILLFRHDPTSENILQLVKAASDIQE 125
S LAHV+++ACSIVDQKFPECGFYG+YDKILLF+HDPTS N+LQLV+++ DIQE
Sbjct: 62 AASE----LAHVKQLACSIVDQKFPECGFYGLYDKILLFKHDPTSANLLQLVRSSGDIQE 117
Query: 126 GDLIEVVLSASATFEDFQIRPHALFVHSYRAPAFCDHCGEMLWGLVRQGLKCEGCGLNYH 185
GDL+EVVLSASATFEDFQIRPHAL VHSYRAPAFCDHCGEML+GLVRQGLKC+GCGLNYH
Sbjct: 118 GDLVEVVLSASATFEDFQIRPHALTVHSYRAPAFCDHCGEMLFGLVRQGLKCDGCGLNYH 177
Query: 186 KRCAFKIPNNCSGVRRRRLSNVSLTGVSTIRTSSAELSTSAPDEPLLQKSPSESFIGREK 245
KRCAF IPNNCSG R+RRLS+ SL ++R ++E +E L +S +E R
Sbjct: 178 KRCAFSIPNNCSGARKRRLSSTSLASGHSVRLGTSESLPCTAEE--LSRSTTELLPRRPP 235
Query: 246 RSNSQS----YIGRPIHLDKILMSKVKVPHTFVIHSYTRPTVCQYCKKLLKGLFRQGLQC 301
S+S S Y GRPI LDK+L+SKVKVPHTF+IHSYTRPTVCQ CKKLLKGLFRQGLQC
Sbjct: 236 SSSSSSSASSYTGRPIELDKMLLSKVKVPHTFLIHSYTRPTVCQACKKLLKGLFRQGLQC 295
Query: 302 KDCRFNCHKRCAPKVPNNCLGEVTINGDLLSPGAESDVVMEEGSDDNDSERNSGLMDDME 361
KDC+FNCHKRCA +VPN+CLGE INGD V MEE +D +++++ S LMD+ E
Sbjct: 296 KDCKFNCHKRCATRVPNDCLGEALINGD---------VPMEEATDFSEADK-SALMDESE 345
Query: 362 EAMV------QDAEMAMAECQNDSGEMQDPDPDHEDANRTISPSTSNNIPLMRVVQSVKH 415
++ V ++A A E + + G+ Q S+ IPLMRVVQSV+H
Sbjct: 346 DSGVIPGSHSENALHASEEEEGEGGKAQ---------------SSLGYIPLMRVVQSVRH 390
Query: 416 TKRKSSTVMKEGWMVHYTSKDTLRKRHYWRLDSKCITLFQNDTGSRYYKEIPLSEILSLE 475
T RKSST ++EGW+VHY++KDTLRKRHYWRLD KCITLFQN+T +RYYKEIPLSEIL++E
Sbjct: 391 TTRKSSTTLREGWVVHYSNKDTLRKRHYWRLDCKCITLFQNNTTNRYYKEIPLSEILTVE 450
Query: 476 PVKTSALIPNGANPHCFEITTANVVYYVGENVVN-PSSPSPNNSVLTSGVGADVARMWEI 534
+ +L+P G NPHCFEI TAN Y+VGE P PS G GA+ AR WE
Sbjct: 451 SAQNFSLVPPGTNPHCFEIVTANATYFVGEMPGGTPGGPS--------GQGAEAARGWET 502
Query: 535 AIQHALMPVIPKGSSVGTGTNLHRDISVSISVSNCQIQENVDISTVYQIFPDEVLGSGQF 594
AI+ ALMPVI + + G HR S+SISVSN QIQENVDI+TVYQIFPDEVLGSGQF
Sbjct: 503 AIRQALMPVILQDAPSAPGHAPHRQASLSISVSNSQIQENVDIATVYQIFPDEVLGSGQF 562
Query: 595 GIVYGGKHRKTGRDVAIKIIDKLRFPTKQESQLRNEVAILQNLHHPGVVNLECMFETPER 654
G+VYGGKHRKTGRDVA+K+IDKLRFPTKQESQLRNEVAILQ+L HPG+VNLECMFETPE+
Sbjct: 563 GVVYGGKHRKTGRDVAVKVIDKLRFPTKQESQLRNEVAILQSLRHPGIVNLECMFETPEK 622
Query: 655 VFVVMEKLHGDMLEMILSSEKGRLPEHITKFLITQILVALRHLHFKNIVHCDLKPENVLL 714
VFVVMEKLHGDMLEMILSSEKGRLPE +TKFLITQILVALRHLHFKNIVHCDLKPENVLL
Sbjct: 623 VFVVMEKLHGDMLEMILSSEKGRLPERLTKFLITQILVALRHLHFKNIVHCDLKPENVLL 682
Query: 715 ASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRNKGYNRSLDMWSVGVIIY 774
ASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVL N+GYNRSLDMWSVGVI+Y
Sbjct: 683 ASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLLNQGYNRSLDMWSVGVIMY 742
Query: 775 VSLSGTFPFNEDEDIHDQIQNAAFMYPPNPWKEISHEAIDLINNLLQVKMRKRYSVDKTL 834
VSLSGTFPFNEDEDI+DQIQNAAFMYP +PW IS AIDLINNLLQVKMRKRYSVDK+L
Sbjct: 743 VSLSGTFPFNEDEDINDQIQNAAFMYPASPWSHISAGAIDLINNLLQVKMRKRYSVDKSL 802
Query: 835 SHPWLQDYQTWLDLRELECKIGERYITHESDDLRWEKYAGEQGLQYPTHLINPSASHSDT 894
SHPWLQ+YQTWLDLRELE K+GERYITHESDD RWE++A E L P +
Sbjct: 803 SHPWLQEYQTWLDLRELEGKMGERYITHESDDARWEQFAAEHPL--PGSGLPTDRDLGGA 860
Query: 895 PETEETEMKALGERVSIL 912
++ +M+ L ER+S+L
Sbjct: 861 CPPQDHDMQGLAERISVL 878
>gi|120659787 protein kinase D2 isoform B [Homo sapiens]
Length = 721
Score = 1011 bits (2613), Expect = 0.0
Identities = 519/758 (68%), Positives = 595/758 (78%), Gaps = 48/758 (6%)
Query: 166 MLWGLVRQGLKCEGCGLNYHKRCAFKIPNNCSGVRRRRLSNVSLTGVSTIRTSSAELSTS 225
ML+GLVRQGLKC+GCGLNYHKRCAF IPNNCSG R+RRLS+ SL ++R ++E
Sbjct: 1 MLFGLVRQGLKCDGCGLNYHKRCAFSIPNNCSGARKRRLSSTSLASGHSVRLGTSESLPC 60
Query: 226 APDEPLLQKSPSESFIGREKRSNSQS----YIGRPIHLDKILMSKVKVPHTFVIHSYTRP 281
+E L +S +E R S+S S Y GRPI LDK+L+SKVKVPHTF+IHSYTRP
Sbjct: 61 TAEE--LSRSTTELLPRRPPSSSSSSSASSYTGRPIELDKMLLSKVKVPHTFLIHSYTRP 118
Query: 282 TVCQYCKKLLKGLFRQGLQCKDCRFNCHKRCAPKVPNNCLGEVTINGDLLSPGAESDVVM 341
TVCQ CKKLLKGLFRQGLQCKDC+FNCHKRCA +VPN+CLGE INGD V M
Sbjct: 119 TVCQACKKLLKGLFRQGLQCKDCKFNCHKRCATRVPNDCLGEALINGD---------VPM 169
Query: 342 EEGSDDNDSERNSGLMDDMEEAMV------QDAEMAMAECQNDSGEMQDPDPDHEDANRT 395
EE +D +++++ S LMD+ E++ V ++A A E + + G+ Q
Sbjct: 170 EEATDFSEADK-SALMDESEDSGVIPGSHSENALHASEEEEGEGGKAQ------------ 216
Query: 396 ISPSTSNNIPLMRVVQSVKHTKRKSSTVMKEGWMVHYTSKDTLRKRHYWRLDSKCITLFQ 455
S+ IPLMRVVQSV+HT RKSST ++EGW+VHY++KDTLRKRHYWRLD KCITLFQ
Sbjct: 217 ---SSLGYIPLMRVVQSVRHTTRKSSTTLREGWVVHYSNKDTLRKRHYWRLDCKCITLFQ 273
Query: 456 NDTGSRYYKEIPLSEILSLEPVKTSALIPNGANPHCFEITTANVVYYVGENVVN-PSSPS 514
N+T +RYYKEIPLSEIL++E + +L+P G NPHCFEI TAN Y+VGE P PS
Sbjct: 274 NNTTNRYYKEIPLSEILTVESAQNFSLVPPGTNPHCFEIVTANATYFVGEMPGGTPGGPS 333
Query: 515 PNNSVLTSGVGADVARMWEIAIQHALMPVIPKGSSVGTGTNLHRDISVSISVSNCQIQEN 574
G GA+ AR WE AI+ ALMPVI + + G HR S+SISVSN QIQEN
Sbjct: 334 --------GQGAEAARGWETAIRQALMPVILQDAPSAPGHAPHRQASLSISVSNSQIQEN 385
Query: 575 VDISTVYQIFPDEVLGSGQFGIVYGGKHRKTGRDVAIKIIDKLRFPTKQESQLRNEVAIL 634
VDI+TVYQIFPDEVLGSGQFG+VYGGKHRKTGRDVA+K+IDKLRFPTKQESQLRNEVAIL
Sbjct: 386 VDIATVYQIFPDEVLGSGQFGVVYGGKHRKTGRDVAVKVIDKLRFPTKQESQLRNEVAIL 445
Query: 635 QNLHHPGVVNLECMFETPERVFVVMEKLHGDMLEMILSSEKGRLPEHITKFLITQILVAL 694
Q+L HPG+VNLECMFETPE+VFVVMEKLHGDMLEMILSSEKGRLPE +TKFLITQILVAL
Sbjct: 446 QSLRHPGIVNLECMFETPEKVFVVMEKLHGDMLEMILSSEKGRLPERLTKFLITQILVAL 505
Query: 695 RHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEV 754
RHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEV
Sbjct: 506 RHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEV 565
Query: 755 LRNKGYNRSLDMWSVGVIIYVSLSGTFPFNEDEDIHDQIQNAAFMYPPNPWKEISHEAID 814
L N+GYNRSLDMWSVGVI+YVSLSGTFPFNEDEDI+DQIQNAAFMYP +PW IS AID
Sbjct: 566 LLNQGYNRSLDMWSVGVIMYVSLSGTFPFNEDEDINDQIQNAAFMYPASPWSHISAGAID 625
Query: 815 LINNLLQVKMRKRYSVDKTLSHPWLQDYQTWLDLRELECKIGERYITHESDDLRWEKYAG 874
LINNLLQVKMRKRYSVDK+LSHPWLQ+YQTWLDLRELE K+GERYITHESDD RWE++A
Sbjct: 626 LINNLLQVKMRKRYSVDKSLSHPWLQEYQTWLDLRELEGKMGERYITHESDDARWEQFAA 685
Query: 875 EQGLQYPTHLINPSASHSDTPETEETEMKALGERVSIL 912
E L P + ++ +M+ L ER+S+L
Sbjct: 686 EHPL--PGSGLPTDRDLGGACPPQDHDMQGLAERISVL 721
Score = 70.1 bits (170), Expect = 9e-12
Identities = 27/53 (50%), Positives = 35/53 (66%)
Query: 146 PHALFVHSYRAPAFCDHCGEMLWGLVRQGLKCEGCGLNYHKRCAFKIPNNCSG 198
PH +HSY P C C ++L GL RQGL+C+ C N HKRCA ++PN+C G
Sbjct: 107 PHTFLIHSYTRPTVCQACKKLLKGLFRQGLQCKDCKFNCHKRCATRVPNDCLG 159
>gi|54112407 protein kinase CHK2 isoform c [Homo sapiens]
Length = 586
Score = 191 bits (485), Expect = 3e-48
Identities = 115/317 (36%), Positives = 184/317 (58%), Gaps = 28/317 (8%)
Query: 550 VGTGTN--LHRDISVSISVSNCQI----QENVDISTVY------QIFPDEVLGSGQFGIV 597
VG G L+ + +++S+S ++ VD +VY + + LGSG G V
Sbjct: 218 VGKGKRRPLNNNSEIALSLSRNKVFVFFDLTVDDQSVYPKALRDEYIMSKTLGSGACGEV 277
Query: 598 YGGKHRKTGRDVAIKIIDKLRFPTKQESQ------LRNEVAILQNLHHPGVVNLECMFET 651
RKT + VAIKII K +F + + E+ IL+ L+HP ++ ++ F+
Sbjct: 278 KLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEILKKLNHPCIIKIKNFFDA 337
Query: 652 PERVFVVMEKLHG-DMLEMILSSEKGRLPEHITKFLITQILVALRHLHFKNIVHCDLKPE 710
E ++V+E + G ++ + ++ ++ RL E K Q+L+A+++LH I+H DLKPE
Sbjct: 338 -EDYYIVLELMEGGELFDKVVGNK--RLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPE 394
Query: 711 NVLLASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVL---RNKGYNRSLDMW 767
NVLL+S + +K+ DFG ++I+GE S R++ GTP YLAPEVL GYNR++D W
Sbjct: 395 NVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCW 454
Query: 768 SVGVIIYVSLSGTFPFNEDE---DIHDQIQNAAFMYPPNPWKEISHEAIDLINNLLQVKM 824
S+GVI+++ LSG PF+E + DQI + + + P W E+S +A+DL+ LL V
Sbjct: 455 SLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEVSEKALDLVKKLLVVDP 514
Query: 825 RKRYSVDKTLSHPWLQD 841
+ R++ ++ L HPWLQD
Sbjct: 515 KARFTTEEALRHPWLQD 531
>gi|6005850 protein kinase CHK2 isoform a [Homo sapiens]
Length = 543
Score = 191 bits (485), Expect = 3e-48
Identities = 115/317 (36%), Positives = 184/317 (58%), Gaps = 28/317 (8%)
Query: 550 VGTGTN--LHRDISVSISVSNCQI----QENVDISTVY------QIFPDEVLGSGQFGIV 597
VG G L+ + +++S+S ++ VD +VY + + LGSG G V
Sbjct: 175 VGKGKRRPLNNNSEIALSLSRNKVFVFFDLTVDDQSVYPKALRDEYIMSKTLGSGACGEV 234
Query: 598 YGGKHRKTGRDVAIKIIDKLRFPTKQESQ------LRNEVAILQNLHHPGVVNLECMFET 651
RKT + VAIKII K +F + + E+ IL+ L+HP ++ ++ F+
Sbjct: 235 KLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEILKKLNHPCIIKIKNFFDA 294
Query: 652 PERVFVVMEKLHG-DMLEMILSSEKGRLPEHITKFLITQILVALRHLHFKNIVHCDLKPE 710
E ++V+E + G ++ + ++ ++ RL E K Q+L+A+++LH I+H DLKPE
Sbjct: 295 -EDYYIVLELMEGGELFDKVVGNK--RLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPE 351
Query: 711 NVLLASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVL---RNKGYNRSLDMW 767
NVLL+S + +K+ DFG ++I+GE S R++ GTP YLAPEVL GYNR++D W
Sbjct: 352 NVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCW 411
Query: 768 SVGVIIYVSLSGTFPFNEDE---DIHDQIQNAAFMYPPNPWKEISHEAIDLINNLLQVKM 824
S+GVI+++ LSG PF+E + DQI + + + P W E+S +A+DL+ LL V
Sbjct: 412 SLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEVSEKALDLVKKLLVVDP 471
Query: 825 RKRYSVDKTLSHPWLQD 841
+ R++ ++ L HPWLQD
Sbjct: 472 KARFTTEEALRHPWLQD 488
>gi|149589021 doublecortin-like kinase 3 [Homo sapiens]
Length = 648
Score = 183 bits (465), Expect = 6e-46
Identities = 104/259 (40%), Positives = 153/259 (59%), Gaps = 11/259 (4%)
Query: 588 VLGSGQFGIVYGGKHRKTGRDVAIKIIDKLRFPTKQESQLRNEVAILQNLHHPGVVNLEC 647
V+G G F +V +HR+T + A+KIIDK R K E + +E+ I+Q+L HP +V L
Sbjct: 361 VIGDGNFAVVKECRHRETRQAYAMKIIDKSRLKGK-EDMVDSEILIIQSLSHPNIVKLHE 419
Query: 648 MFETPERVFVVMEKLHG-DMLEMILSSEKGRLPEHITKFLITQILVALRHLHFKNIVHCD 706
++ET +++++E + G D+ + I+ S K PE +I + AL H+H K+IVH D
Sbjct: 420 VYETDMEIYLILEYVQGGDLFDAIIESVK--FPEPDAALMIMDLCKALVHMHDKSIVHRD 477
Query: 707 LKPENVLLA-SADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRNKGYNRSLD 765
LKPEN+L+ + D +KL DFG A+ + F +V GTP Y+APE+L KGY +D
Sbjct: 478 LKPENLLVQRNEDKSTTLKLADFGLAKHVVRPIF--TVCGTPTYVAPEILSEKGYGLEVD 535
Query: 766 MWSVGVIIYVSLSGTFPFNEDEDIHDQ----IQNAAFMYPPNPWKEISHEAIDLINNLLQ 821
MW+ GVI+Y+ L G PF E D+ IQ F + P W IS A DL++ LL
Sbjct: 536 MWAAGVILYILLCGFPPFRSPERDQDELFNIIQLGHFEFLPPYWDNISDAAKDLVSRLLV 595
Query: 822 VKMRKRYSVDKTLSHPWLQ 840
V +KRY+ + L HPW++
Sbjct: 596 VDPKKRYTAHQVLQHPWIE 614
>gi|9966875 calcium/calmodulin-dependent protein kinase ID isoform 1
[Homo sapiens]
Length = 357
Score = 177 bits (450), Expect = 3e-44
Identities = 98/267 (36%), Positives = 156/267 (58%), Gaps = 8/267 (2%)
Query: 576 DISTVYQIFPDEVLGSGQFGIVYGGKHRKTGRDVAIKIIDKLRFPTKQESQLRNEVAILQ 635
DI +++ E LG+G F V + + TG+ A+K I K K ES + NE+A+L+
Sbjct: 18 DIKKIFEF--KETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGK-ESSIENEIAVLR 74
Query: 636 NLHHPGVVNLECMFETPERVFVVMEKLHG-DMLEMILSSEKGRLPEHITKFLITQILVAL 694
+ H +V LE ++E+P +++VM+ + G ++ + I+ EKG E LI Q+L A+
Sbjct: 75 KIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIV--EKGFYTEKDASTLIRQVLDAV 132
Query: 695 RHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEV 754
+LH IVH DLKPEN+L S D ++ + DFG +++ G+ + GTP Y+APEV
Sbjct: 133 YYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTPGYVAPEV 192
Query: 755 LRNKGYNRSLDMWSVGVIIYVSLSGTFPFNEDED--IHDQIQNAAFMYPPNPWKEISHEA 812
L K Y++++D WS+GVI Y+ L G PF ++ D + +QI A + + W +IS A
Sbjct: 193 LAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDDISDSA 252
Query: 813 IDLINNLLQVKMRKRYSVDKTLSHPWL 839
D I NL++ KRY+ ++ HPW+
Sbjct: 253 KDFIRNLMEKDPNKRYTCEQAARHPWI 279
>gi|23943850 calcium/calmodulin-dependent protein kinase ID isoform
2 [Homo sapiens]
Length = 385
Score = 177 bits (450), Expect = 3e-44
Identities = 98/267 (36%), Positives = 156/267 (58%), Gaps = 8/267 (2%)
Query: 576 DISTVYQIFPDEVLGSGQFGIVYGGKHRKTGRDVAIKIIDKLRFPTKQESQLRNEVAILQ 635
DI +++ E LG+G F V + + TG+ A+K I K K ES + NE+A+L+
Sbjct: 18 DIKKIFEF--KETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGK-ESSIENEIAVLR 74
Query: 636 NLHHPGVVNLECMFETPERVFVVMEKLHG-DMLEMILSSEKGRLPEHITKFLITQILVAL 694
+ H +V LE ++E+P +++VM+ + G ++ + I+ EKG E LI Q+L A+
Sbjct: 75 KIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIV--EKGFYTEKDASTLIRQVLDAV 132
Query: 695 RHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEV 754
+LH IVH DLKPEN+L S D ++ + DFG +++ G+ + GTP Y+APEV
Sbjct: 133 YYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTPGYVAPEV 192
Query: 755 LRNKGYNRSLDMWSVGVIIYVSLSGTFPFNEDED--IHDQIQNAAFMYPPNPWKEISHEA 812
L K Y++++D WS+GVI Y+ L G PF ++ D + +QI A + + W +IS A
Sbjct: 193 LAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDDISDSA 252
Query: 813 IDLINNLLQVKMRKRYSVDKTLSHPWL 839
D I NL++ KRY+ ++ HPW+
Sbjct: 253 KDFIRNLMEKDPNKRYTCEQAARHPWI 279
>gi|14196445 calcium/calmodulin-dependent protein kinase IG [Homo
sapiens]
Length = 476
Score = 172 bits (435), Expect = 2e-42
Identities = 95/256 (37%), Positives = 154/256 (60%), Gaps = 8/256 (3%)
Query: 587 EVLGSGQFGIVYGGKHRKTGRDVAIKIIDKLRFPTKQESQLRNEVAILQNLHHPGVVNLE 646
EVLGSG F V+ K R TG+ A+K I K P ++S L NE+A+L+ + H +V LE
Sbjct: 27 EVLGSGAFSEVFLVKQRLTGKLFALKCIKKS--PAFRDSSLENEIAVLKKIKHENIVTLE 84
Query: 647 CMFETPERVFVVMEKLHG-DMLEMILSSEKGRLPEHITKFLITQILVALRHLHFKNIVHC 705
++E+ ++VM+ + G ++ + IL E+G E +I Q+L A+++LH IVH
Sbjct: 85 DIYESTTHYYLVMQLVSGGELFDRIL--ERGVYTEKDASLVIQQVLSAVKYLHENGIVHR 142
Query: 706 DLKPENVLLASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRNKGYNRSLD 765
DLKPEN+L + + ++ + DFG +++ + + GTP Y+APEVL K Y++++D
Sbjct: 143 DLKPENLLYLTPEENSKIMITDFGLSKM-EQNGIMSTACGTPGYVAPEVLAQKPYSKAVD 201
Query: 766 MWSVGVIIYVSLSGTFPFNEDED--IHDQIQNAAFMYPPNPWKEISHEAIDLINNLLQVK 823
WS+GVI Y+ L G PF E+ + + ++I+ + + W +IS A D I +LL+
Sbjct: 202 CWSIGVITYILLCGYPPFYEETESKLFEKIKEGYYEFESPFWDDISESAKDFICHLLEKD 261
Query: 824 MRKRYSVDKTLSHPWL 839
+RY+ +K LSHPW+
Sbjct: 262 PNERYTCEKALSHPWI 277
>gi|156713430 doublecortin-like kinase 2 isoform b [Homo sapiens]
Length = 765
Score = 171 bits (434), Expect = 2e-42
Identities = 111/300 (37%), Positives = 165/300 (55%), Gaps = 14/300 (4%)
Query: 548 SSVGTGTNLHRDISVSISVSNCQIQENVDISTVYQIFPDEVLGSGQFGIVYGGKHRKTGR 607
S+V G L R IS V+ + E+ + Y+I +V+G G F +V R TG+
Sbjct: 361 SNVNGGPELDRCISPE-GVNGNRCSESSTLLEKYKI--GKVIGDGNFAVVKECIDRSTGK 417
Query: 608 DVAIKIIDKLRFPTKQESQLRNEVAILQNLHHPGVVNLECMFETPERVFVVMEKLHG-DM 666
+ A+KIIDK + K E + NEV+IL+ + HP ++ L ET +F+VME + G D+
Sbjct: 418 EFALKIIDKAKCCGK-EHLIENEVSILRRVKHPNIIMLVEEMETATELFLVMELVKGGDL 476
Query: 667 LEMILSSEKGRLPEHITKFLITQILVALRHLHFKNIVHCDLKPENVLLAS-ADPFPQVKL 725
+ I SS K E ++ + ALR+LH +IVH D+KPEN+L+ D +KL
Sbjct: 477 FDAITSSTK--YTERDGSAMVYNLANALRYLHGLSIVHRDIKPENLLVCEYPDGTKSLKL 534
Query: 726 CDFGFARIIGEKSFRRSVVGTPAYLAPEVLRNKGYNRSLDMWSVGVIIYVSLSGTFPF-- 783
DFG A ++ + +V GTP Y+APE++ GY +D+W+ GVI Y+ L G PF
Sbjct: 535 GDFGLATVVEGPLY--TVCGTPTYVAPEIIAETGYGLKVDIWAAGVITYILLCGFPPFRS 592
Query: 784 --NEDEDIHDQIQNAAFMYPPNPWKEISHEAIDLINNLLQVKMRKRYSVDKTLSHPWLQD 841
N ED+ DQI +P W I+ A +LI+ +LQV + R + + LSHPW+ D
Sbjct: 593 ENNLQEDLFDQILAGKLEFPAPYWDNITDSAKELISQMLQVNVEARCTAGQILSHPWVSD 652
>gi|156713428 doublecortin-like kinase 2 isoform a [Homo sapiens]
Length = 766
Score = 171 bits (434), Expect = 2e-42
Identities = 111/300 (37%), Positives = 165/300 (55%), Gaps = 14/300 (4%)
Query: 548 SSVGTGTNLHRDISVSISVSNCQIQENVDISTVYQIFPDEVLGSGQFGIVYGGKHRKTGR 607
S+V G L R IS V+ + E+ + Y+I +V+G G F +V R TG+
Sbjct: 362 SNVNGGPELDRCISPE-GVNGNRCSESSTLLEKYKI--GKVIGDGNFAVVKECIDRSTGK 418
Query: 608 DVAIKIIDKLRFPTKQESQLRNEVAILQNLHHPGVVNLECMFETPERVFVVMEKLHG-DM 666
+ A+KIIDK + K E + NEV+IL+ + HP ++ L ET +F+VME + G D+
Sbjct: 419 EFALKIIDKAKCCGK-EHLIENEVSILRRVKHPNIIMLVEEMETATELFLVMELVKGGDL 477
Query: 667 LEMILSSEKGRLPEHITKFLITQILVALRHLHFKNIVHCDLKPENVLLAS-ADPFPQVKL 725
+ I SS K E ++ + ALR+LH +IVH D+KPEN+L+ D +KL
Sbjct: 478 FDAITSSTK--YTERDGSAMVYNLANALRYLHGLSIVHRDIKPENLLVCEYPDGTKSLKL 535
Query: 726 CDFGFARIIGEKSFRRSVVGTPAYLAPEVLRNKGYNRSLDMWSVGVIIYVSLSGTFPF-- 783
DFG A ++ + +V GTP Y+APE++ GY +D+W+ GVI Y+ L G PF
Sbjct: 536 GDFGLATVVEGPLY--TVCGTPTYVAPEIIAETGYGLKVDIWAAGVITYILLCGFPPFRS 593
Query: 784 --NEDEDIHDQIQNAAFMYPPNPWKEISHEAIDLINNLLQVKMRKRYSVDKTLSHPWLQD 841
N ED+ DQI +P W I+ A +LI+ +LQV + R + + LSHPW+ D
Sbjct: 594 ENNLQEDLFDQILAGKLEFPAPYWDNITDSAKELISQMLQVNVEARCTAGQILSHPWVSD 653
>gi|4502553 calcium/calmodulin-dependent protein kinase I [Homo
sapiens]
Length = 370
Score = 170 bits (430), Expect = 6e-42
Identities = 96/267 (35%), Positives = 156/267 (58%), Gaps = 8/267 (2%)
Query: 576 DISTVYQIFPDEVLGSGQFGIVYGGKHRKTGRDVAIKIIDKLRFPTKQESQLRNEVAILQ 635
DI +Y +VLG+G F V + ++T + VAIK I K K E + NE+A+L
Sbjct: 15 DIRDIYDF--RDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGK-EGSMENEIAVLH 71
Query: 636 NLHHPGVVNLECMFETPERVFVVMEKLHG-DMLEMILSSEKGRLPEHITKFLITQILVAL 694
+ HP +V L+ ++E+ ++++M+ + G ++ + I+ EKG E LI Q+L A+
Sbjct: 72 KIKHPNIVALDDIYESGGHLYLIMQLVSGGELFDRIV--EKGFYTERDASRLIFQVLDAV 129
Query: 695 RHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEV 754
++LH IVH DLKPEN+L S D ++ + DFG +++ S + GTP Y+APEV
Sbjct: 130 KYLHDLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLSTACGTPGYVAPEV 189
Query: 755 LRNKGYNRSLDMWSVGVIIYVSLSGTFPFNEDED--IHDQIQNAAFMYPPNPWKEISHEA 812
L K Y++++D WS+GVI Y+ L G PF ++ D + +QI A + + W +IS A
Sbjct: 190 LAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSPYWDDISDSA 249
Query: 813 IDLINNLLQVKMRKRYSVDKTLSHPWL 839
D I +L++ KR++ ++ L HPW+
Sbjct: 250 KDFIRHLMEKDPEKRFTCEQALQHPWI 276
>gi|4502557 calcium/calmodulin-dependent protein kinase IV [Homo
sapiens]
Length = 473
Score = 167 bits (423), Expect = 4e-41
Identities = 93/255 (36%), Positives = 145/255 (56%), Gaps = 10/255 (3%)
Query: 589 LGSGQFGIVYGGKHRKTGRDVAIKIIDKLRFPTKQESQLRNEVAILQNLHHPGVVNLECM 648
LG G IVY K + T + A+K++ K T + +R E+ +L L HP ++ L+ +
Sbjct: 52 LGRGATSIVYRCKQKGTQKPYALKVLKK----TVDKKIVRTEIGVLLRLSHPNIIKLKEI 107
Query: 649 FETPERVFVVMEKLHG-DMLEMILSSEKGRLPEHITKFLITQILVALRHLHFKNIVHCDL 707
FETP + +V+E + G ++ + I+ EKG E + QIL A+ +LH IVH DL
Sbjct: 108 FETPTEISLVLELVTGGELFDRIV--EKGYYSERDAADAVKQILEAVAYLHENGIVHRDL 165
Query: 708 KPENVLLASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRNKGYNRSLDMW 767
KPEN+L A+ P +K+ DFG ++I+ + ++V GTP Y APE+LR Y +DMW
Sbjct: 166 KPENLLYATPAPDAPLKIADFGLSKIVEHQVLMKTVCGTPGYCAPEILRGCAYGPEVDMW 225
Query: 768 SVGVIIYVSLSGTFPFNE---DEDIHDQIQNAAFMYPPNPWKEISHEAIDLINNLLQVKM 824
SVG+I Y+ L G PF + D+ + +I N + + W E+S A DL+ L+ +
Sbjct: 226 SVGIITYILLCGFEPFYDERGDQFMFRRILNCEYYFISPWWDEVSLNAKDLVRKLIVLDP 285
Query: 825 RKRYSVDKTLSHPWL 839
+KR + + L HPW+
Sbjct: 286 KKRLTTFQALQHPWV 300
>gi|209364621 pregnancy upregulated non-ubiquitously expressed CaM
kinase isoform b [Homo sapiens]
Length = 360
Score = 162 bits (409), Expect = 2e-39
Identities = 97/267 (36%), Positives = 155/267 (58%), Gaps = 9/267 (3%)
Query: 576 DISTVYQIFPDEVLGSGQFGIVYGGKHRKTGRDVAIKIIDKLRFPTKQESQLRNEVAILQ 635
DIS+VY+I E LGSG F V + R + VA+K I K K E+ + NE+A+L+
Sbjct: 27 DISSVYEI--RERLGSGAFSEVVLAQERGSAHLVALKCIPKKALRGK-EALVENEIAVLR 83
Query: 636 NLHHPGVVNLECMFETPERVFVVMEKLHG-DMLEMILSSEKGRLPEHITKFLITQILVAL 694
+ HP +V LE + E+P +++ ME + G ++ + I+ E+G E L+ Q+L A+
Sbjct: 84 RISHPNIVALEDVHESPSHLYLAMELVTGGELFDRIM--ERGSYTEKDASHLVGQVLGAV 141
Query: 695 RHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEV 754
+LH IVH DLKPEN+L A+ ++ + DFG ++I + GTP Y+APE+
Sbjct: 142 SYLHSLGIVHRDLKPENLLYATPFEDSKIMVSDFGLSKIQAGNMLG-TACGTPGYVAPEL 200
Query: 755 LRNKGYNRSLDMWSVGVIIYVSLSGTFPFNEDED--IHDQIQNAAFMYPPNPWKEISHEA 812
L K Y +++D+W++GVI Y+ L G PF ++ D + QI A++ + W +IS A
Sbjct: 201 LEQKPYGKAVDVWALGVISYILLCGYPPFYDESDPELFSQILRASYEFDSPFWDDISESA 260
Query: 813 IDLINNLLQVKMRKRYSVDKTLSHPWL 839
D I +LL+ +KR++ + L H W+
Sbjct: 261 KDFIRHLLERDPQKRFTCQQALRHLWI 287
>gi|209364619 pregnancy upregulated non-ubiquitously expressed CaM
kinase isoform a [Homo sapiens]
Length = 426
Score = 162 bits (409), Expect = 2e-39
Identities = 97/267 (36%), Positives = 155/267 (58%), Gaps = 9/267 (3%)
Query: 576 DISTVYQIFPDEVLGSGQFGIVYGGKHRKTGRDVAIKIIDKLRFPTKQESQLRNEVAILQ 635
DIS+VY+I E LGSG F V + R + VA+K I K K E+ + NE+A+L+
Sbjct: 93 DISSVYEI--RERLGSGAFSEVVLAQERGSAHLVALKCIPKKALRGK-EALVENEIAVLR 149
Query: 636 NLHHPGVVNLECMFETPERVFVVMEKLHG-DMLEMILSSEKGRLPEHITKFLITQILVAL 694
+ HP +V LE + E+P +++ ME + G ++ + I+ E+G E L+ Q+L A+
Sbjct: 150 RISHPNIVALEDVHESPSHLYLAMELVTGGELFDRIM--ERGSYTEKDASHLVGQVLGAV 207
Query: 695 RHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEV 754
+LH IVH DLKPEN+L A+ ++ + DFG ++I + GTP Y+APE+
Sbjct: 208 SYLHSLGIVHRDLKPENLLYATPFEDSKIMVSDFGLSKIQAGNMLG-TACGTPGYVAPEL 266
Query: 755 LRNKGYNRSLDMWSVGVIIYVSLSGTFPFNEDED--IHDQIQNAAFMYPPNPWKEISHEA 812
L K Y +++D+W++GVI Y+ L G PF ++ D + QI A++ + W +IS A
Sbjct: 267 LEQKPYGKAVDVWALGVISYILLCGYPPFYDESDPELFSQILRASYEFDSPFWDDISESA 326
Query: 813 IDLINNLLQVKMRKRYSVDKTLSHPWL 839
D I +LL+ +KR++ + L H W+
Sbjct: 327 KDFIRHLLERDPQKRFTCQQALRHLWI 353
>gi|212549756 calcium/calmodulin-dependent protein kinase II delta
isoform 4 [Homo sapiens]
Length = 489
Score = 160 bits (406), Expect = 4e-39
Identities = 96/263 (36%), Positives = 141/263 (53%), Gaps = 8/263 (3%)
Query: 581 YQIFPDEVLGSGQFGIVYGGKHRKTGRDVAIKIIDKLRFPTKQESQLRNEVAILQNLHHP 640
YQ+F E LG G F +V TG++ A KII+ + + +L E I + L HP
Sbjct: 14 YQLF--EELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHP 71
Query: 641 GVVNLECMFETPERVFVVMEKLHG-DMLEMILSSEKGRLPEHITKFLITQILVALRHLHF 699
+V L ++V + + G ++ E I++ E E I QIL ++ H H
Sbjct: 72 NIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREY--YSEADASHCIQQILESVNHCHL 129
Query: 700 KNIVHCDLKPENVLLASADPFPQVKLCDFGFA-RIIGEKSFRRSVVGTPAYLAPEVLRNK 758
IVH DLKPEN+LLAS VKL DFG A + G++ GTP YL+PEVLR
Sbjct: 130 NGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKD 189
Query: 759 GYNRSLDMWSVGVIIYVSLSGTFPFNEDED--IHDQIQNAAFMYPPNPWKEISHEAIDLI 816
Y + +DMW+ GVI+Y+ L G PF +++ ++ QI+ A+ +P W ++ EA DLI
Sbjct: 190 PYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLI 249
Query: 817 NNLLQVKMRKRYSVDKTLSHPWL 839
N +L + KR + + L HPW+
Sbjct: 250 NKMLTINPAKRITASEALKHPWI 272
>gi|26667183 calcium/calmodulin-dependent protein kinase II delta
isoform 1 [Homo sapiens]
Length = 478
Score = 160 bits (406), Expect = 4e-39
Identities = 96/263 (36%), Positives = 141/263 (53%), Gaps = 8/263 (3%)
Query: 581 YQIFPDEVLGSGQFGIVYGGKHRKTGRDVAIKIIDKLRFPTKQESQLRNEVAILQNLHHP 640
YQ+F E LG G F +V TG++ A KII+ + + +L E I + L HP
Sbjct: 14 YQLF--EELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHP 71
Query: 641 GVVNLECMFETPERVFVVMEKLHG-DMLEMILSSEKGRLPEHITKFLITQILVALRHLHF 699
+V L ++V + + G ++ E I++ E E I QIL ++ H H
Sbjct: 72 NIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREY--YSEADASHCIQQILESVNHCHL 129
Query: 700 KNIVHCDLKPENVLLASADPFPQVKLCDFGFA-RIIGEKSFRRSVVGTPAYLAPEVLRNK 758
IVH DLKPEN+LLAS VKL DFG A + G++ GTP YL+PEVLR
Sbjct: 130 NGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKD 189
Query: 759 GYNRSLDMWSVGVIIYVSLSGTFPFNEDED--IHDQIQNAAFMYPPNPWKEISHEAIDLI 816
Y + +DMW+ GVI+Y+ L G PF +++ ++ QI+ A+ +P W ++ EA DLI
Sbjct: 190 PYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLI 249
Query: 817 NNLLQVKMRKRYSVDKTLSHPWL 839
N +L + KR + + L HPW+
Sbjct: 250 NKMLTINPAKRITASEALKHPWI 272
>gi|212549753 calcium/calmodulin-dependent protein kinase II delta
isoform 5 [Homo sapiens]
Length = 492
Score = 160 bits (406), Expect = 4e-39
Identities = 96/263 (36%), Positives = 141/263 (53%), Gaps = 8/263 (3%)
Query: 581 YQIFPDEVLGSGQFGIVYGGKHRKTGRDVAIKIIDKLRFPTKQESQLRNEVAILQNLHHP 640
YQ+F E LG G F +V TG++ A KII+ + + +L E I + L HP
Sbjct: 14 YQLF--EELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHP 71
Query: 641 GVVNLECMFETPERVFVVMEKLHG-DMLEMILSSEKGRLPEHITKFLITQILVALRHLHF 699
+V L ++V + + G ++ E I++ E E I QIL ++ H H
Sbjct: 72 NIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREY--YSEADASHCIQQILESVNHCHL 129
Query: 700 KNIVHCDLKPENVLLASADPFPQVKLCDFGFA-RIIGEKSFRRSVVGTPAYLAPEVLRNK 758
IVH DLKPEN+LLAS VKL DFG A + G++ GTP YL+PEVLR
Sbjct: 130 NGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKD 189
Query: 759 GYNRSLDMWSVGVIIYVSLSGTFPFNEDED--IHDQIQNAAFMYPPNPWKEISHEAIDLI 816
Y + +DMW+ GVI+Y+ L G PF +++ ++ QI+ A+ +P W ++ EA DLI
Sbjct: 190 PYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLI 249
Query: 817 NNLLQVKMRKRYSVDKTLSHPWL 839
N +L + KR + + L HPW+
Sbjct: 250 NKMLTINPAKRITASEALKHPWI 272
>gi|26667186 calcium/calmodulin-dependent protein kinase II delta
isoform 1 [Homo sapiens]
Length = 478
Score = 160 bits (406), Expect = 4e-39
Identities = 96/263 (36%), Positives = 141/263 (53%), Gaps = 8/263 (3%)
Query: 581 YQIFPDEVLGSGQFGIVYGGKHRKTGRDVAIKIIDKLRFPTKQESQLRNEVAILQNLHHP 640
YQ+F E LG G F +V TG++ A KII+ + + +L E I + L HP
Sbjct: 14 YQLF--EELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHP 71
Query: 641 GVVNLECMFETPERVFVVMEKLHG-DMLEMILSSEKGRLPEHITKFLITQILVALRHLHF 699
+V L ++V + + G ++ E I++ E E I QIL ++ H H
Sbjct: 72 NIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREY--YSEADASHCIQQILESVNHCHL 129
Query: 700 KNIVHCDLKPENVLLASADPFPQVKLCDFGFA-RIIGEKSFRRSVVGTPAYLAPEVLRNK 758
IVH DLKPEN+LLAS VKL DFG A + G++ GTP YL+PEVLR
Sbjct: 130 NGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKD 189
Query: 759 GYNRSLDMWSVGVIIYVSLSGTFPFNEDED--IHDQIQNAAFMYPPNPWKEISHEAIDLI 816
Y + +DMW+ GVI+Y+ L G PF +++ ++ QI+ A+ +P W ++ EA DLI
Sbjct: 190 PYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLI 249
Query: 817 NNLLQVKMRKRYSVDKTLSHPWL 839
N +L + KR + + L HPW+
Sbjct: 250 NKMLTINPAKRITASEALKHPWI 272
>gi|26667189 calcium/calmodulin-dependent protein kinase II delta
isoform 2 [Homo sapiens]
Length = 478
Score = 160 bits (406), Expect = 4e-39
Identities = 96/263 (36%), Positives = 141/263 (53%), Gaps = 8/263 (3%)
Query: 581 YQIFPDEVLGSGQFGIVYGGKHRKTGRDVAIKIIDKLRFPTKQESQLRNEVAILQNLHHP 640
YQ+F E LG G F +V TG++ A KII+ + + +L E I + L HP
Sbjct: 14 YQLF--EELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHP 71
Query: 641 GVVNLECMFETPERVFVVMEKLHG-DMLEMILSSEKGRLPEHITKFLITQILVALRHLHF 699
+V L ++V + + G ++ E I++ E E I QIL ++ H H
Sbjct: 72 NIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREY--YSEADASHCIQQILESVNHCHL 129
Query: 700 KNIVHCDLKPENVLLASADPFPQVKLCDFGFA-RIIGEKSFRRSVVGTPAYLAPEVLRNK 758
IVH DLKPEN+LLAS VKL DFG A + G++ GTP YL+PEVLR
Sbjct: 130 NGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKD 189
Query: 759 GYNRSLDMWSVGVIIYVSLSGTFPFNEDED--IHDQIQNAAFMYPPNPWKEISHEAIDLI 816
Y + +DMW+ GVI+Y+ L G PF +++ ++ QI+ A+ +P W ++ EA DLI
Sbjct: 190 PYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLI 249
Query: 817 NNLLQVKMRKRYSVDKTLSHPWL 839
N +L + KR + + L HPW+
Sbjct: 250 NKMLTINPAKRITASEALKHPWI 272
>gi|26667180 calcium/calmodulin-dependent protein kinase II delta
isoform 3 [Homo sapiens]
Length = 499
Score = 160 bits (406), Expect = 4e-39
Identities = 96/263 (36%), Positives = 141/263 (53%), Gaps = 8/263 (3%)
Query: 581 YQIFPDEVLGSGQFGIVYGGKHRKTGRDVAIKIIDKLRFPTKQESQLRNEVAILQNLHHP 640
YQ+F E LG G F +V TG++ A KII+ + + +L E I + L HP
Sbjct: 14 YQLF--EELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHP 71
Query: 641 GVVNLECMFETPERVFVVMEKLHG-DMLEMILSSEKGRLPEHITKFLITQILVALRHLHF 699
+V L ++V + + G ++ E I++ E E I QIL ++ H H
Sbjct: 72 NIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREY--YSEADASHCIQQILESVNHCHL 129
Query: 700 KNIVHCDLKPENVLLASADPFPQVKLCDFGFA-RIIGEKSFRRSVVGTPAYLAPEVLRNK 758
IVH DLKPEN+LLAS VKL DFG A + G++ GTP YL+PEVLR
Sbjct: 130 NGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKD 189
Query: 759 GYNRSLDMWSVGVIIYVSLSGTFPFNEDED--IHDQIQNAAFMYPPNPWKEISHEAIDLI 816
Y + +DMW+ GVI+Y+ L G PF +++ ++ QI+ A+ +P W ++ EA DLI
Sbjct: 190 PYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLI 249
Query: 817 NNLLQVKMRKRYSVDKTLSHPWL 839
N +L + KR + + L HPW+
Sbjct: 250 NKMLTINPAKRITASEALKHPWI 272
>gi|27901803 protein serine kinase H1 [Homo sapiens]
Length = 424
Score = 157 bits (397), Expect = 4e-38
Identities = 96/291 (32%), Positives = 152/291 (52%), Gaps = 9/291 (3%)
Query: 588 VLGSGQFGIVYGGKHRKTGRDVAIKIIDKLRFPTKQESQLRNEVAILQNLHHPGVVNLEC 647
++G G F V +HR T + AIK+I+ ++ + +E+ +L+ + H ++ L
Sbjct: 103 LIGRGSFSRVVRVEHRATRQPYAIKMIETKYREGREVCE--SELRVLRRVRHANIIQLVE 160
Query: 648 MFETPERVFVVME-KLHGDMLEMILSSEKGRLPEHITKFLITQILVALRHLHFKNIVHCD 706
+FET ERV++VME G++ + I++ KG E ++ +L +R+LH I H D
Sbjct: 161 VFETQERVYMVMELATGGELFDRIIA--KGSFTERDATRVLQMVLDGVRYLHALGITHRD 218
Query: 707 LKPENVLLASADPFPQVKLCDFGFA--RIIGEKSFRRSVVGTPAYLAPEVLRNKGYNRSL 764
LKPEN+L ++ + DFG A R G+ ++ GTP Y+APEVL K Y S+
Sbjct: 219 LKPENLLYYHPGTDSKIIITDFGLASARKKGDDCLMKTTCGTPEYIAPEVLVRKPYTNSV 278
Query: 765 DMWSVGVIIYVSLSGTFPFNEDE--DIHDQIQNAAFMYPPNPWKEISHEAIDLINNLLQV 822
DMW++GVI Y+ LSGT PF +D ++ QI + Y PW +S+ A D I+ LL V
Sbjct: 279 DMWALGVIAYILLSGTMPFEDDNRTRLYRQILRGKYSYSGEPWPSVSNLAKDFIDRLLTV 338
Query: 823 KMRKRYSVDKTLSHPWLQDYQTWLDLRELECKIGERYITHESDDLRWEKYA 873
R + + L HPW+ ++ L I + + S + K A
Sbjct: 339 DPGARMTALQALRHPWVVSMAASSSMKNLHRSISQNLLKRASSRCQSTKSA 389
>gi|109255245 serine/threonine kinase 17a [Homo sapiens]
Length = 414
Score = 157 bits (396), Expect = 6e-38
Identities = 95/324 (29%), Positives = 157/324 (48%), Gaps = 22/324 (6%)
Query: 581 YQIFPDEVLGSGQFGIVYGGKHRKTGRDVAIKIIDKLRFPTKQESQLRNEVAILQNLH-H 639
Y + P LG G+F +V + +G++ A K + K R ++ +E+A+L+ +
Sbjct: 59 YSLCPGRELGRGKFAVVRKCIKKDSGKEFAAKFMRKRRKGQDCRMEIIHEIAVLELAQDN 118
Query: 640 PGVVNLECMFETPERVFVVME-KLHGDMLEMILSSEKGRLPEHITKFLITQILVALRHLH 698
P V+NL ++ET + +V+E G++ + ++ + E + L+ QIL + LH
Sbjct: 119 PWVINLHEVYETASEMILVLEYAAGGEIFDQCVADREEAFKEKDVQRLMRQILEGVHFLH 178
Query: 699 FKNIVHCDLKPENVLLASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRNK 758
+++VH DLKP+N+LL S P +K+ DFG +RI+ R ++GTP Y+APE+L
Sbjct: 179 TRDVVHLDLKPQNILLTSESPLGDIKIVDFGLSRILKNSEELREIMGTPEYVAPEILSYD 238
Query: 759 GYNRSLDMWSVGVIIYVSLSGTFPF--NEDEDIHDQIQNAAFMYPPNPWKEISHEAIDLI 816
+ + DMWS+GV+ YV L+G PF N+ ++ I Y + +S A+D I
Sbjct: 239 PISMATDMWSIGVLTYVMLTGISPFLGNDKQETFLNISQMNLSYSEEEFDVLSESAVDFI 298
Query: 817 NNLLQVKMRKRYSVDKTLSHPWLQDYQTWLDLRELECKIGERYITHESDDLRWEKYAGEQ 876
LL K R + ++ L HPWL + R EK E
Sbjct: 299 RTLLVKKPEDRATAEECLKHPWLTQSSI------------------QEPSFRMEKALEEA 340
Query: 877 GLQYPTHLINPSASHSDTPETEET 900
H + S +D ET+E+
Sbjct: 341 NALQEGHSVPEINSDTDKSETKES 364
>gi|26667199 calcium/calmodulin-dependent protein kinase II gamma
isoform 3 [Homo sapiens]
Length = 518
Score = 155 bits (393), Expect = 1e-37
Identities = 96/263 (36%), Positives = 145/263 (55%), Gaps = 8/263 (3%)
Query: 581 YQIFPDEVLGSGQFGIVYGGKHRKTGRDVAIKIIDKLRFPTKQESQLRNEVAILQNLHHP 640
YQ+F E LG G F +V + + ++ A KII+ + + +L E I + L HP
Sbjct: 14 YQLF--EELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDHQKLEREARICRLLKHP 71
Query: 641 GVVNLECMFETPERVFVVMEKLHG-DMLEMILSSEKGRLPEHITKFLITQILVALRHLHF 699
+V L ++V + + G ++ E I++ E E I QIL ++ H+H
Sbjct: 72 NIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREY--YSEADASHCIHQILESVNHIHQ 129
Query: 700 KNIVHCDLKPENVLLASADPFPQVKLCDFGFA-RIIGEKSFRRSVVGTPAYLAPEVLRNK 758
+IVH DLKPEN+LLAS VKL DFG A + GE+ GTP YL+PEVLR
Sbjct: 130 HDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRKD 189
Query: 759 GYNRSLDMWSVGVIIYVSLSGTFPF-NEDE-DIHDQIQNAAFMYPPNPWKEISHEAIDLI 816
Y + +D+W+ GVI+Y+ L G PF +ED+ ++ QI+ A+ +P W ++ EA +LI
Sbjct: 190 PYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLI 249
Query: 817 NNLLQVKMRKRYSVDKTLSHPWL 839
N +L + KR + D+ L HPW+
Sbjct: 250 NQMLTINPAKRITADQALKHPWV 272
>gi|25952118 calcium/calmodulin-dependent protein kinase II alpha
isoform 2 [Homo sapiens]
Length = 478
Score = 155 bits (393), Expect = 1e-37
Identities = 95/268 (35%), Positives = 141/268 (52%), Gaps = 8/268 (2%)
Query: 581 YQIFPDEVLGSGQFGIVYGGKHRKTGRDVAIKIIDKLRFPTKQESQLRNEVAILQNLHHP 640
YQ+F E LG G F +V G++ A KII+ + + +L E I + L HP
Sbjct: 13 YQLF--EELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHP 70
Query: 641 GVVNLECMFETPERVFVVMEKLHG-DMLEMILSSEKGRLPEHITKFLITQILVALRHLHF 699
+V L +++ + + G ++ E I++ E E I QIL A+ H H
Sbjct: 71 NIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREY--YSEADASHCIQQILEAVLHCHQ 128
Query: 700 KNIVHCDLKPENVLLASADPFPQVKLCDFGFA-RIIGEKSFRRSVVGTPAYLAPEVLRNK 758
+VH DLKPEN+LLAS VKL DFG A + GE+ GTP YL+PEVLR
Sbjct: 129 MGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKD 188
Query: 759 GYNRSLDMWSVGVIIYVSLSGTFPFNEDED--IHDQIQNAAFMYPPNPWKEISHEAIDLI 816
Y + +D+W+ GVI+Y+ L G PF +++ ++ QI+ A+ +P W ++ EA DLI
Sbjct: 189 PYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLI 248
Query: 817 NNLLQVKMRKRYSVDKTLSHPWLQDYQT 844
N +L + KR + + L HPW+ T
Sbjct: 249 NKMLTINPSKRITAAEALKHPWISHRST 276
>gi|25952114 calcium/calmodulin-dependent protein kinase II alpha
isoform 1 [Homo sapiens]
Length = 489
Score = 155 bits (393), Expect = 1e-37
Identities = 95/268 (35%), Positives = 141/268 (52%), Gaps = 8/268 (2%)
Query: 581 YQIFPDEVLGSGQFGIVYGGKHRKTGRDVAIKIIDKLRFPTKQESQLRNEVAILQNLHHP 640
YQ+F E LG G F +V G++ A KII+ + + +L E I + L HP
Sbjct: 13 YQLF--EELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHP 70
Query: 641 GVVNLECMFETPERVFVVMEKLHG-DMLEMILSSEKGRLPEHITKFLITQILVALRHLHF 699
+V L +++ + + G ++ E I++ E E I QIL A+ H H
Sbjct: 71 NIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREY--YSEADASHCIQQILEAVLHCHQ 128
Query: 700 KNIVHCDLKPENVLLASADPFPQVKLCDFGFA-RIIGEKSFRRSVVGTPAYLAPEVLRNK 758
+VH DLKPEN+LLAS VKL DFG A + GE+ GTP YL+PEVLR
Sbjct: 129 MGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKD 188
Query: 759 GYNRSLDMWSVGVIIYVSLSGTFPFNEDED--IHDQIQNAAFMYPPNPWKEISHEAIDLI 816
Y + +D+W+ GVI+Y+ L G PF +++ ++ QI+ A+ +P W ++ EA DLI
Sbjct: 189 PYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLI 248
Query: 817 NNLLQVKMRKRYSVDKTLSHPWLQDYQT 844
N +L + KR + + L HPW+ T
Sbjct: 249 NKMLTINPSKRITAAEALKHPWISHRST 276
>gi|26667191 calcium/calmodulin-dependent protein kinase II gamma
isoform 4 [Homo sapiens]
Length = 495
Score = 155 bits (393), Expect = 1e-37
Identities = 96/263 (36%), Positives = 145/263 (55%), Gaps = 8/263 (3%)
Query: 581 YQIFPDEVLGSGQFGIVYGGKHRKTGRDVAIKIIDKLRFPTKQESQLRNEVAILQNLHHP 640
YQ+F E LG G F +V + + ++ A KII+ + + +L E I + L HP
Sbjct: 14 YQLF--EELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDHQKLEREARICRLLKHP 71
Query: 641 GVVNLECMFETPERVFVVMEKLHG-DMLEMILSSEKGRLPEHITKFLITQILVALRHLHF 699
+V L ++V + + G ++ E I++ E E I QIL ++ H+H
Sbjct: 72 NIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREY--YSEADASHCIHQILESVNHIHQ 129
Query: 700 KNIVHCDLKPENVLLASADPFPQVKLCDFGFA-RIIGEKSFRRSVVGTPAYLAPEVLRNK 758
+IVH DLKPEN+LLAS VKL DFG A + GE+ GTP YL+PEVLR
Sbjct: 130 HDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRKD 189
Query: 759 GYNRSLDMWSVGVIIYVSLSGTFPF-NEDE-DIHDQIQNAAFMYPPNPWKEISHEAIDLI 816
Y + +D+W+ GVI+Y+ L G PF +ED+ ++ QI+ A+ +P W ++ EA +LI
Sbjct: 190 PYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLI 249
Query: 817 NNLLQVKMRKRYSVDKTLSHPWL 839
N +L + KR + D+ L HPW+
Sbjct: 250 NQMLTINPAKRITADQALKHPWV 272
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.135 0.406
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 37,531,673
Number of Sequences: 37866
Number of extensions: 1837529
Number of successful extensions: 13448
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 652
Number of HSP's successfully gapped in prelim test: 321
Number of HSP's that attempted gapping in prelim test: 9863
Number of HSP's gapped (non-prelim): 1986
length of query: 912
length of database: 18,247,518
effective HSP length: 111
effective length of query: 801
effective length of database: 14,044,392
effective search space: 11249557992
effective search space used: 11249557992
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.