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Search of human proteins with 115529445
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|115529445 phosphodiesterase 4C isoform PDE4C-1 [Homo
sapiens]
(712 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|115529445 phosphodiesterase 4C isoform PDE4C-1 [Homo sapiens] 1422 0.0
gi|149363646 phosphodiesterase 4C isoform PDE4C-3 [Homo sapiens] 1254 0.0
gi|149363666 phosphodiesterase 4C isoform PDE4C-2 [Homo sapiens] 1203 0.0
gi|157277988 phosphodiesterase 4D isoform 1 [Homo sapiens] 947 0.0
gi|32306513 phosphodiesterase 4D isoform 2 [Homo sapiens] 918 0.0
gi|162329608 phosphodiesterase 4A isoform 1 [Homo sapiens] 900 0.0
gi|82799484 phosphodiesterase 4B isoform 3 [Homo sapiens] 856 0.0
gi|162329610 phosphodiesterase 4A isoform 2 [Homo sapiens] 855 0.0
gi|82799486 phosphodiesterase 4B isoform 1 [Homo sapiens] 852 0.0
gi|32171241 phosphodiesterase 4B isoform 1 [Homo sapiens] 852 0.0
gi|162329612 phosphodiesterase 4A isoform 3 [Homo sapiens] 850 0.0
gi|82799482 phosphodiesterase 4B isoform 2 [Homo sapiens] 735 0.0
gi|5453862 phosphodiesterase 4A isoform 4 [Homo sapiens] 688 0.0
gi|4505677 phosphodiesterase 1B [Homo sapiens] 238 1e-62
gi|51102295 phosphodiesterase 1A isoform 2 [Homo sapiens] 234 3e-61
gi|21361262 phosphodiesterase 1A isoform 1 [Homo sapiens] 234 3e-61
gi|4826894 phosphodiesterase 1C [Homo sapiens] 229 5e-60
gi|47132537 phosphodiesterase 8A isoform 2 [Homo sapiens] 224 3e-58
gi|27734721 phosphodiesterase 8A isoform 1 [Homo sapiens] 224 3e-58
gi|9506959 phosphodiesterase 7B [Homo sapiens] 213 5e-55
gi|71164875 phosphodiesterase 8B isoform 2 [Homo sapiens] 209 7e-54
gi|71164873 phosphodiesterase 8B isoform 4 [Homo sapiens] 209 7e-54
gi|71164869 phosphodiesterase 8B isoform 5 [Homo sapiens] 209 7e-54
gi|71164867 phosphodiesterase 8B isoform 3 [Homo sapiens] 209 7e-54
gi|26006851 phosphodiesterase 8B isoform 1 [Homo sapiens] 209 7e-54
gi|24429566 phosphodiesterase 7A isoform a [Homo sapiens] 208 2e-53
gi|24429564 phosphodiesterase 7A isoform b [Homo sapiens] 194 2e-49
gi|48762752 phosphodiesterase 9A isoform g [Homo sapiens] 171 3e-42
gi|48762754 phosphodiesterase 9A isoform g [Homo sapiens] 171 3e-42
gi|48762750 phosphodiesterase 9A isoform o [Homo sapiens] 171 3e-42
>gi|115529445 phosphodiesterase 4C isoform PDE4C-1 [Homo sapiens]
Length = 712
Score = 1422 bits (3680), Expect = 0.0
Identities = 712/712 (100%), Positives = 712/712 (100%)
Query: 1 MENLGVGEGAEACSRLSRSRGRHSMTRAPKHLWRQPRRPIRIQQRFYSDPDKSAGCRERD 60
MENLGVGEGAEACSRLSRSRGRHSMTRAPKHLWRQPRRPIRIQQRFYSDPDKSAGCRERD
Sbjct: 1 MENLGVGEGAEACSRLSRSRGRHSMTRAPKHLWRQPRRPIRIQQRFYSDPDKSAGCRERD 60
Query: 61 LSPRPELRKSRLSWPVSSCRRFDLENGLSCGRRALDPQSSPGLGRIMQAPVPHSQRRESF 120
LSPRPELRKSRLSWPVSSCRRFDLENGLSCGRRALDPQSSPGLGRIMQAPVPHSQRRESF
Sbjct: 61 LSPRPELRKSRLSWPVSSCRRFDLENGLSCGRRALDPQSSPGLGRIMQAPVPHSQRRESF 120
Query: 121 LYRSDSDYELSPKAMSRNSSVASDLHGEDMIVTPFAQVLASLRTVRSNVAALARQQCLGA 180
LYRSDSDYELSPKAMSRNSSVASDLHGEDMIVTPFAQVLASLRTVRSNVAALARQQCLGA
Sbjct: 121 LYRSDSDYELSPKAMSRNSSVASDLHGEDMIVTPFAQVLASLRTVRSNVAALARQQCLGA 180
Query: 181 AKQGPVGNPSSSNQLPPAEDTGQKLALETLDELDWCLDQLETLQTRHSVGEMASNKFKRI 240
AKQGPVGNPSSSNQLPPAEDTGQKLALETLDELDWCLDQLETLQTRHSVGEMASNKFKRI
Sbjct: 181 AKQGPVGNPSSSNQLPPAEDTGQKLALETLDELDWCLDQLETLQTRHSVGEMASNKFKRI 240
Query: 241 LNRELTHLSETSRSGNQVSEYISRTFLDQQTEVELPKVTAEEAPQPMSRISGLHGLCHSA 300
LNRELTHLSETSRSGNQVSEYISRTFLDQQTEVELPKVTAEEAPQPMSRISGLHGLCHSA
Sbjct: 241 LNRELTHLSETSRSGNQVSEYISRTFLDQQTEVELPKVTAEEAPQPMSRISGLHGLCHSA 300
Query: 301 SLSSATVPRFGVQTDQEEQLAKELEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLL 360
SLSSATVPRFGVQTDQEEQLAKELEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLL
Sbjct: 301 SLSSATVPRFGVQTDQEEQLAKELEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLL 360
Query: 361 KTFQIPADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILA 420
KTFQIPADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILA
Sbjct: 361 KTFQIPADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILA 420
Query: 421 ALFASAIHDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAENCDIFQNL 480
ALFASAIHDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAENCDIFQNL
Sbjct: 421 ALFASAIHDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAENCDIFQNL 480
Query: 481 SAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQN 540
SAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQN
Sbjct: 481 SAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQN 540
Query: 541 LVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVGF 600
LVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVGF
Sbjct: 541 LVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVGF 600
Query: 601 IDYIAHPLWETWADLVHPDAQDLLDTLEDNREWYQSKIPRSPSDLTNPERDGPDRFQFEL 660
IDYIAHPLWETWADLVHPDAQDLLDTLEDNREWYQSKIPRSPSDLTNPERDGPDRFQFEL
Sbjct: 601 IDYIAHPLWETWADLVHPDAQDLLDTLEDNREWYQSKIPRSPSDLTNPERDGPDRFQFEL 660
Query: 661 TLEEAEEEDEEEEEEGEETALAKEALELPDTELLSPEAGPDPGDLPLDNQRT 712
TLEEAEEEDEEEEEEGEETALAKEALELPDTELLSPEAGPDPGDLPLDNQRT
Sbjct: 661 TLEEAEEEDEEEEEEGEETALAKEALELPDTELLSPEAGPDPGDLPLDNQRT 712
>gi|149363646 phosphodiesterase 4C isoform PDE4C-3 [Homo sapiens]
Length = 680
Score = 1254 bits (3244), Expect = 0.0
Identities = 631/631 (100%), Positives = 631/631 (100%)
Query: 82 FDLENGLSCGRRALDPQSSPGLGRIMQAPVPHSQRRESFLYRSDSDYELSPKAMSRNSSV 141
FDLENGLSCGRRALDPQSSPGLGRIMQAPVPHSQRRESFLYRSDSDYELSPKAMSRNSSV
Sbjct: 50 FDLENGLSCGRRALDPQSSPGLGRIMQAPVPHSQRRESFLYRSDSDYELSPKAMSRNSSV 109
Query: 142 ASDLHGEDMIVTPFAQVLASLRTVRSNVAALARQQCLGAAKQGPVGNPSSSNQLPPAEDT 201
ASDLHGEDMIVTPFAQVLASLRTVRSNVAALARQQCLGAAKQGPVGNPSSSNQLPPAEDT
Sbjct: 110 ASDLHGEDMIVTPFAQVLASLRTVRSNVAALARQQCLGAAKQGPVGNPSSSNQLPPAEDT 169
Query: 202 GQKLALETLDELDWCLDQLETLQTRHSVGEMASNKFKRILNRELTHLSETSRSGNQVSEY 261
GQKLALETLDELDWCLDQLETLQTRHSVGEMASNKFKRILNRELTHLSETSRSGNQVSEY
Sbjct: 170 GQKLALETLDELDWCLDQLETLQTRHSVGEMASNKFKRILNRELTHLSETSRSGNQVSEY 229
Query: 262 ISRTFLDQQTEVELPKVTAEEAPQPMSRISGLHGLCHSASLSSATVPRFGVQTDQEEQLA 321
ISRTFLDQQTEVELPKVTAEEAPQPMSRISGLHGLCHSASLSSATVPRFGVQTDQEEQLA
Sbjct: 230 ISRTFLDQQTEVELPKVTAEEAPQPMSRISGLHGLCHSASLSSATVPRFGVQTDQEEQLA 289
Query: 322 KELEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLLKTFQIPADTLATYLLMLEGHY 381
KELEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLLKTFQIPADTLATYLLMLEGHY
Sbjct: 290 KELEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLLKTFQIPADTLATYLLMLEGHY 349
Query: 382 HANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAIHDVDHPGVSNQFLI 441
HANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAIHDVDHPGVSNQFLI
Sbjct: 350 HANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAIHDVDHPGVSNQFLI 409
Query: 442 NTNSELALMYNDASVLENHHLAVGFKLLQAENCDIFQNLSAKQRLSLRRMVIDMVLATDM 501
NTNSELALMYNDASVLENHHLAVGFKLLQAENCDIFQNLSAKQRLSLRRMVIDMVLATDM
Sbjct: 410 NTNSELALMYNDASVLENHHLAVGFKLLQAENCDIFQNLSAKQRLSLRRMVIDMVLATDM 469
Query: 502 SKHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQNLVHCADLSNPTKPLPLYRQWT 561
SKHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQNLVHCADLSNPTKPLPLYRQWT
Sbjct: 470 SKHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQNLVHCADLSNPTKPLPLYRQWT 529
Query: 562 DRIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVGFIDYIAHPLWETWADLVHPDAQ 621
DRIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVGFIDYIAHPLWETWADLVHPDAQ
Sbjct: 530 DRIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVGFIDYIAHPLWETWADLVHPDAQ 589
Query: 622 DLLDTLEDNREWYQSKIPRSPSDLTNPERDGPDRFQFELTLEEAEEEDEEEEEEGEETAL 681
DLLDTLEDNREWYQSKIPRSPSDLTNPERDGPDRFQFELTLEEAEEEDEEEEEEGEETAL
Sbjct: 590 DLLDTLEDNREWYQSKIPRSPSDLTNPERDGPDRFQFELTLEEAEEEDEEEEEEGEETAL 649
Query: 682 AKEALELPDTELLSPEAGPDPGDLPLDNQRT 712
AKEALELPDTELLSPEAGPDPGDLPLDNQRT
Sbjct: 650 AKEALELPDTELLSPEAGPDPGDLPLDNQRT 680
>gi|149363666 phosphodiesterase 4C isoform PDE4C-2 [Homo sapiens]
Length = 606
Score = 1203 bits (3112), Expect = 0.0
Identities = 606/606 (100%), Positives = 606/606 (100%)
Query: 107 MQAPVPHSQRRESFLYRSDSDYELSPKAMSRNSSVASDLHGEDMIVTPFAQVLASLRTVR 166
MQAPVPHSQRRESFLYRSDSDYELSPKAMSRNSSVASDLHGEDMIVTPFAQVLASLRTVR
Sbjct: 1 MQAPVPHSQRRESFLYRSDSDYELSPKAMSRNSSVASDLHGEDMIVTPFAQVLASLRTVR 60
Query: 167 SNVAALARQQCLGAAKQGPVGNPSSSNQLPPAEDTGQKLALETLDELDWCLDQLETLQTR 226
SNVAALARQQCLGAAKQGPVGNPSSSNQLPPAEDTGQKLALETLDELDWCLDQLETLQTR
Sbjct: 61 SNVAALARQQCLGAAKQGPVGNPSSSNQLPPAEDTGQKLALETLDELDWCLDQLETLQTR 120
Query: 227 HSVGEMASNKFKRILNRELTHLSETSRSGNQVSEYISRTFLDQQTEVELPKVTAEEAPQP 286
HSVGEMASNKFKRILNRELTHLSETSRSGNQVSEYISRTFLDQQTEVELPKVTAEEAPQP
Sbjct: 121 HSVGEMASNKFKRILNRELTHLSETSRSGNQVSEYISRTFLDQQTEVELPKVTAEEAPQP 180
Query: 287 MSRISGLHGLCHSASLSSATVPRFGVQTDQEEQLAKELEDTNKWGLDVFKVAELSGNRPL 346
MSRISGLHGLCHSASLSSATVPRFGVQTDQEEQLAKELEDTNKWGLDVFKVAELSGNRPL
Sbjct: 181 MSRISGLHGLCHSASLSSATVPRFGVQTDQEEQLAKELEDTNKWGLDVFKVAELSGNRPL 240
Query: 347 TAIIFSIFQERDLLKTFQIPADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLAT 406
TAIIFSIFQERDLLKTFQIPADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLAT
Sbjct: 241 TAIIFSIFQERDLLKTFQIPADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLAT 300
Query: 407 PALEAVFTDLEILAALFASAIHDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGF 466
PALEAVFTDLEILAALFASAIHDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGF
Sbjct: 301 PALEAVFTDLEILAALFASAIHDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGF 360
Query: 467 KLLQAENCDIFQNLSAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVL 526
KLLQAENCDIFQNLSAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVL
Sbjct: 361 KLLQAENCDIFQNLSAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVL 420
Query: 527 LLDNYSDRIQVLQNLVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISPMC 586
LLDNYSDRIQVLQNLVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISPMC
Sbjct: 421 LLDNYSDRIQVLQNLVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISPMC 480
Query: 587 DKHTASVEKSQVGFIDYIAHPLWETWADLVHPDAQDLLDTLEDNREWYQSKIPRSPSDLT 646
DKHTASVEKSQVGFIDYIAHPLWETWADLVHPDAQDLLDTLEDNREWYQSKIPRSPSDLT
Sbjct: 481 DKHTASVEKSQVGFIDYIAHPLWETWADLVHPDAQDLLDTLEDNREWYQSKIPRSPSDLT 540
Query: 647 NPERDGPDRFQFELTLEEAEEEDEEEEEEGEETALAKEALELPDTELLSPEAGPDPGDLP 706
NPERDGPDRFQFELTLEEAEEEDEEEEEEGEETALAKEALELPDTELLSPEAGPDPGDLP
Sbjct: 541 NPERDGPDRFQFELTLEEAEEEDEEEEEEGEETALAKEALELPDTELLSPEAGPDPGDLP 600
Query: 707 LDNQRT 712
LDNQRT
Sbjct: 601 LDNQRT 606
>gi|157277988 phosphodiesterase 4D isoform 1 [Homo sapiens]
Length = 809
Score = 947 bits (2447), Expect = 0.0
Identities = 485/686 (70%), Positives = 561/686 (81%), Gaps = 21/686 (3%)
Query: 41 RIQQRFYSDPDKSAGCRERDLSP-------RPELRKSRLSWPVS--SCRRFDLENGLSCG 91
R++ R YSD ++ CR D + RP L+KSR+SWP S RRFD++NG S G
Sbjct: 103 RVRHRGYSDTERYLYCRAMDRTSYAVETGHRPGLKKSRMSWPSSFQGLRRFDVDNGTSAG 162
Query: 92 RRALDPQSSPGLGRIMQAPVPHSQRRESFLYRSDSDYELSPKAMSRNSSVASDLHGEDMI 151
R LDP +SPG G I+QA HSQRRESFLYRSDSDY+LSPK+MSRNSS+ASD+HG+D+I
Sbjct: 163 RSPLDPMTSPGSGLILQANFVHSQRRESFLYRSDSDYDLSPKSMSRNSSIASDIHGDDLI 222
Query: 152 VTPFAQVLASLRTVRSNVAALARQQCLGAAKQGPVGNPSSSNQLPPAEDTGQKLALETLD 211
VTPFAQVLASLRTVR+N AAL Q +K+ P+ N S N+ E+ QKLA ETL+
Sbjct: 223 VTPFAQVLASLRTVRNNFAALTNLQDRAPSKRSPMCNQPSINKATITEEAYQKLASETLE 282
Query: 212 ELDWCLDQLETLQTRHSVGEMASNKFKRILNRELTHLSETSRSGNQVSEYISRTFLDQQT 271
ELDWCLDQLETLQTRHSV EMASNKFKR+LNRELTHLSE SRSGNQVSE+IS TFLD+Q
Sbjct: 283 ELDWCLDQLETLQTRHSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEFISNTFLDKQH 342
Query: 272 EVELPKVTAEEAPQ---PMSRISGLHGLCHSASLSSATVPRFGVQTDQEEQLAKELEDTN 328
EVE+P T +E + PMS+ISG+ L HS+SL+++++PRFGV+T+QE+ LAKELED N
Sbjct: 343 EVEIPSPTQKEKEKKKRPMSQISGVKKLMHSSSLTNSSIPRFGVKTEQEDVLAKELEDVN 402
Query: 329 KWGLDVFKVAELSGNRPLTAIIFSIFQERDLLKTFQIPADTLATYLLMLEGHYHANVAYH 388
KWGL VF++AELSGNRPLT I+ +IFQERDLLKTF+IP DTL TYL+ LE HYHA+VAYH
Sbjct: 403 KWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYH 462
Query: 389 NSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAIHDVDHPGVSNQFLINTNSELA 448
N++HAADV QSTHVLL+TPALEAVFTDLEILAA+FASAIHDVDHPGVSNQFLINTNSELA
Sbjct: 463 NNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELA 522
Query: 449 LMYNDASVLENHHLAVGFKLLQAENCDIFQNLSAKQRLSLRRMVIDMVLATDMSKHMNLL 508
LMYND+SVLENHHLAVGFKLLQ ENCDIFQNL+ KQR SLR+MVID+VLATDMSKHMNLL
Sbjct: 523 LMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLL 582
Query: 509 ADLKTMVETKKVTSLGVLLLDNYSDRIQVLQNLVHCADLSNPTKPLPLYRQWTDRIMAEF 568
ADLKTMVETKKVTS GVLLLDNYSDRIQVLQN+VHCADLSNPTKPL LYRQWTDRIM EF
Sbjct: 583 ADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEF 642
Query: 569 FQQGDRERESGLDISPMCDKHTASVEKSQVGFIDYIAHPLWETWADLVHPDAQDLLDTLE 628
F+QGDRERE G++ISPMCDKH ASVEKSQVGFIDYI HPLWETWADLVHPDAQD+LDTLE
Sbjct: 643 FRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLE 702
Query: 629 DNREWYQSKIPRSPSDLTNPERDG----PDRFQFELTLEEAEEEDEEEEEEGEETALAKE 684
DNREWYQS IP+SPS + +G ++FQFELTLEE E D E++ + +E
Sbjct: 703 DNREWYQSTIPQSPSPAPDDPEEGRQGQTEKFQFELTLEEDGESDTEKDSGSQ----VEE 758
Query: 685 ALELPDTELLSPEAGPDPGDLPLDNQ 710
D++ L + + ++PLD Q
Sbjct: 759 DTSCSDSKTLCTQ-DSESTEIPLDEQ 783
>gi|32306513 phosphodiesterase 4D isoform 2 [Homo sapiens]
Length = 673
Score = 918 bits (2372), Expect = 0.0
Identities = 465/636 (73%), Positives = 534/636 (83%), Gaps = 12/636 (1%)
Query: 82 FDLENGLSCGRRALDPQSSPGLGRIMQAPVPHSQRRESFLYRSDSDYELSPKAMSRNSSV 141
FD++NG S GR LDP +SPG G I+QA HSQRRESFLYRSDSDY+LSPK+MSRNSS+
Sbjct: 17 FDVDNGTSAGRSPLDPMTSPGSGLILQANFVHSQRRESFLYRSDSDYDLSPKSMSRNSSI 76
Query: 142 ASDLHGEDMIVTPFAQVLASLRTVRSNVAALARQQCLGAAKQGPVGNPSSSNQLPPAEDT 201
ASD+HG+D+IVTPFAQVLASLRTVR+N AAL Q +K+ P+ N S N+ E+
Sbjct: 77 ASDIHGDDLIVTPFAQVLASLRTVRNNFAALTNLQDRAPSKRSPMCNQPSINKATITEEA 136
Query: 202 GQKLALETLDELDWCLDQLETLQTRHSVGEMASNKFKRILNRELTHLSETSRSGNQVSEY 261
QKLA ETL+ELDWCLDQLETLQTRHSV EMASNKFKR+LNRELTHLSE SRSGNQVSE+
Sbjct: 137 YQKLASETLEELDWCLDQLETLQTRHSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEF 196
Query: 262 ISRTFLDQQTEVELPKVTAEEAPQ---PMSRISGLHGLCHSASLSSATVPRFGVQTDQEE 318
IS TFLD+Q EVE+P T +E + PMS+ISG+ L HS+SL+++++PRFGV+T+QE+
Sbjct: 197 ISNTFLDKQHEVEIPSPTQKEKEKKKRPMSQISGVKKLMHSSSLTNSSIPRFGVKTEQED 256
Query: 319 QLAKELEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLLKTFQIPADTLATYLLMLE 378
LAKELED NKWGL VF++AELSGNRPLT I+ +IFQERDLLKTF+IP DTL TYL+ LE
Sbjct: 257 VLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLE 316
Query: 379 GHYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAIHDVDHPGVSNQ 438
HYHA+VAYHN++HAADV QSTHVLL+TPALEAVFTDLEILAA+FASAIHDVDHPGVSNQ
Sbjct: 317 DHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQ 376
Query: 439 FLINTNSELALMYNDASVLENHHLAVGFKLLQAENCDIFQNLSAKQRLSLRRMVIDMVLA 498
FLINTNSELALMYND+SVLENHHLAVGFKLLQ ENCDIFQNL+ KQR SLR+MVID+VLA
Sbjct: 377 FLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLA 436
Query: 499 TDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQNLVHCADLSNPTKPLPLYR 558
TDMSKHMNLLADLKTMVETKKVTS GVLLLDNYSDRIQVLQN+VHCADLSNPTKPL LYR
Sbjct: 437 TDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYR 496
Query: 559 QWTDRIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVGFIDYIAHPLWETWADLVHP 618
QWTDRIM EFF+QGDRERE G++ISPMCDKH ASVEKSQVGFIDYI HPLWETWADLVHP
Sbjct: 497 QWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHP 556
Query: 619 DAQDLLDTLEDNREWYQSKIPRSPSDLTNPERDG----PDRFQFELTLEEAEEEDEEEEE 674
DAQD+LDTLEDNREWYQS IP+SPS + +G ++FQFELTLEE E D E++
Sbjct: 557 DAQDILDTLEDNREWYQSTIPQSPSPAPDDPEEGRQGQTEKFQFELTLEEDGESDTEKDS 616
Query: 675 EGEETALAKEALELPDTELLSPEAGPDPGDLPLDNQ 710
+ +E D++ L + + ++PLD Q
Sbjct: 617 GSQ----VEEDTSCSDSKTLCTQ-DSESTEIPLDEQ 647
>gi|162329608 phosphodiesterase 4A isoform 1 [Homo sapiens]
Length = 886
Score = 900 bits (2327), Expect = 0.0
Identities = 484/720 (67%), Positives = 555/720 (77%), Gaps = 61/720 (8%)
Query: 21 GRHSMTRAPKHLWRQPRRPIRIQQRFYSDPDKSAGCRER------------DLSPRPELR 68
G+ ++ P+HLWRQPR PIRIQQR YSD + A RER D S RP LR
Sbjct: 22 GQATLKPPPQHLWRQPRTPIRIQQRGYSDSAERAE-RERQPHRPIERADAMDTSDRPGLR 80
Query: 69 KSRLSWPVS--------------SCRRFDLENGL--SCGRRALDPQSSPGLGRIMQAPVP 112
+R+SWP S S RRF+ ENG S GR LD Q+SPGL ++ A
Sbjct: 81 TTRMSWPSSFHGTGTGSGGAGGGSSRRFEAENGPTPSPGRSPLDSQASPGL--VLHAGAA 138
Query: 113 HSQRRESFLYRSDSDYELSPKAMSRNSSVASDLHGEDMIVTPFAQVLASLRTVRSNVAAL 172
SQRRESFLYRSDSDY++SPK MSRNSSV S+ H ED+IVTPFAQVLASLR+VRSN + L
Sbjct: 139 TSQRRESFLYRSDSDYDMSPKTMSRNSSVTSEAHAEDLIVTPFAQVLASLRSVRSNFSLL 198
Query: 173 ARQQCLGAAKQGPVGNPSSSNQLPPAEDTGQKLALETLDELDWCLDQLETLQTRHSVGEM 232
+ + K+ P+G P+ + +E+T Q+LA ETL+ELDWCL+QLET+QT SV EM
Sbjct: 199 TNVP-VPSNKRSPLGGPTPVCKATLSEETCQQLARETLEELDWCLEQLETMQTYRSVSEM 257
Query: 233 ASNKFKRILNRELTHLSETSRSGNQVSEYISRTFLDQQTEVELPKVTAEE-----AP--- 284
AS+KFKR+LNRELTHLSE SRSGNQVSEYIS TFLD+Q EVE+P T +E AP
Sbjct: 258 ASHKFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVEIPSPTMKEREKQQAPRPR 317
Query: 285 ------------QPMSRISGLHGLCHSASLSSATVPRFGVQTDQEEQLAKELEDTNKWGL 332
QPMS+I+GL L HS SL+++ +PRFGV+TDQEE LA+ELE+ NKWGL
Sbjct: 318 PSQPPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKTDQEELLAQELENLNKWGL 377
Query: 333 DVFKVAELSGNRPLTAIIFSIFQERDLLKTFQIPADTLATYLLMLEGHYHANVAYHNSLH 392
++F V++ +G R LT I++ IFQERDLLK F+IP DT+ TY+L LE HYHA+VAYHNSLH
Sbjct: 378 NIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLH 437
Query: 393 AADVAQSTHVLLATPALEAVFTDLEILAALFASAIHDVDHPGVSNQFLINTNSELALMYN 452
AADV QSTHVLLATPAL+AVFTDLEILAALFA+AIHDVDHPGVSNQFLINTNSELALMYN
Sbjct: 438 AADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYN 497
Query: 453 DASVLENHHLAVGFKLLQAENCDIFQNLSAKQRLSLRRMVIDMVLATDMSKHMNLLADLK 512
D SVLENHHLAVGFKLLQ +NCDIFQNLS +QR SLR+MVIDMVLATDMSKHM LLADLK
Sbjct: 498 DESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLK 557
Query: 513 TMVETKKVTSLGVLLLDNYSDRIQVLQNLVHCADLSNPTKPLPLYRQWTDRIMAEFFQQG 572
TMVETKKVTS GVLLLDNYSDRIQVL+N+VHCADLSNPTKPL LYRQWTDRIMAEFFQQG
Sbjct: 558 TMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQG 617
Query: 573 DRERESGLDISPMCDKHTASVEKSQVGFIDYIAHPLWETWADLVHPDAQDLLDTLEDNRE 632
DRERE G++ISPMCDKHTASVEKSQVGFIDYI HPLWETWADLVHPDAQ++LDTLEDNR+
Sbjct: 618 DRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPDAQEILDTLEDNRD 677
Query: 633 WYQSKIPRSPSDLTNPERDG------PDRFQFELTLEEAEEEDEEEEEEGEETALAKEAL 686
WY S I +SPS E G PD+FQFELTL EEE+EEE + A+EAL
Sbjct: 678 WYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFELTL---EEEEEEEISMAQIPCTAQEAL 734
>gi|82799484 phosphodiesterase 4B isoform 3 [Homo sapiens]
Length = 721
Score = 856 bits (2211), Expect = 0.0
Identities = 452/692 (65%), Positives = 539/692 (77%), Gaps = 18/692 (2%)
Query: 11 EACSRLSRSRGRHSMTRAPKHLWRQPRRPIRIQQRFYSDPDKSAGCRERDLSPRPELRKS 70
E C + + + H P+ +P P +I R S P +++ C R L +R+
Sbjct: 16 EVCIKTFKEQ-MHLELELPRLPGNRPTSP-KISPR--SSP-RNSPCFFRKLLVNKSIRQR 70
Query: 71 RLSWPVSSCRRFDLENGLSCGRRALDPQSSPGLGRIMQAPVP-HSQRRESFLYRSDSDYE 129
R +C FD+ENG S GR LDPQ+S G ++ A P HSQRRESFLYRSDSDY+
Sbjct: 71 RRFTVAHTC--FDVENGPSPGRSPLDPQASSSAGLVLHATFPGHSQRRESFLYRSDSDYD 128
Query: 130 LSPKAMSRNSSVASDLHGEDMIVTPFAQVLASLRTVRSNVAALARQQCLGAAKQGPVGNP 189
LSPKAMSRNSS+ S+ HG+D+IVTPFAQVLASLR+VR+N L + K+ P +
Sbjct: 129 LSPKAMSRNSSLPSEQHGDDLIVTPFAQVLASLRSVRNNFTILTNLHGT-SNKRSPAASQ 187
Query: 190 SSSNQLPPAEDTGQKLALETLDELDWCLDQLETLQTRHSVGEMASNKFKRILNRELTHLS 249
+++ P E++ QKLA+ETL+ELDWCLDQLET+QT SV EMASNKFKR+LNRELTHLS
Sbjct: 188 PPVSRVNPQEESYQKLAMETLEELDWCLDQLETIQTYRSVSEMASNKFKRMLNRELTHLS 247
Query: 250 ETSRSGNQVSEYISRTFLDQQTEVELPKVTAEEAP-----QPMSRISGLHGLCHSASLSS 304
E SRSGNQVSEYIS TFLD+Q +VE+P T ++ Q M++ISG+ L HS+SL++
Sbjct: 248 EMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKKKQQLMTQISGVKKLMHSSSLNN 307
Query: 305 ATVPRFGVQTDQEEQLAKELEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLLKTFQ 364
++ RFGV T+ E+ LAKELED NKWGL++F VA S NRPLT I+++IFQERDLLKTF+
Sbjct: 308 TSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFR 367
Query: 365 IPADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFA 424
I +DT TY++ LE HYH++VAYHNSLHAADVAQSTHVLL+TPAL+AVFTDLEILAA+FA
Sbjct: 368 ISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFA 427
Query: 425 SAIHDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAENCDIFQNLSAKQ 484
+AIHDVDHPGVSNQFLINTNSELALMYND SVLENHHLAVGFKLLQ E+CDIF NL+ KQ
Sbjct: 428 AAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFMNLTKKQ 487
Query: 485 RLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQNLVHC 544
R +LR+MVIDMVLATDMSKHM+LLADLKTMVETKKVTS GVLLLDNY+DRIQVL+N+VHC
Sbjct: 488 RQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHC 547
Query: 545 ADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVGFIDYI 604
ADLSNPTK L LYRQWTDRIM EFFQQGD+ERE G++ISPMCDKHTASVEKSQVGFIDYI
Sbjct: 548 ADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGFIDYI 607
Query: 605 AHPLWETWADLVHPDAQDLLDTLEDNREWYQSKIPRSPS---DLTNPERDG-PDRFQFEL 660
HPLWETWADLV PDAQD+LDTLEDNR WYQS IP+SPS D N + G ++FQFEL
Sbjct: 608 VHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSPSPPLDEQNRDCQGLMEKFQFEL 667
Query: 661 TLEEAEEEDEEEEEEGEETALAKEALELPDTE 692
TL+E + E E+E EG + + L + D E
Sbjct: 668 TLDEEDSEGPEKEGEGHSYFSSTKTLCVIDPE 699
>gi|162329610 phosphodiesterase 4A isoform 2 [Homo sapiens]
Length = 860
Score = 855 bits (2208), Expect = 0.0
Identities = 460/688 (66%), Positives = 532/688 (77%), Gaps = 44/688 (6%)
Query: 27 RAPKHLWRQPRRPIRIQQRFYSDPDKSAGCRERDLSPRPELRKSRLSWPVSSCRRFDLEN 86
RAP+ P P+ F++ P + R R L +L R +W + F+ EN
Sbjct: 37 RAPRRPRSPPSSPV-----FFASPSPTFRRRLRLLRSCQDL--GRQAWAGAG---FEAEN 86
Query: 87 GL--SCGRRALDPQSSPGLGRIMQAPVPHSQRRESFLYRSDSDYELSPKAMSRNSSVASD 144
G S GR LD Q+SPGL ++ A SQRRESFLYRSDSDY++SPK MSRNSSV S+
Sbjct: 87 GPTPSPGRSPLDSQASPGL--VLHAGAATSQRRESFLYRSDSDYDMSPKTMSRNSSVTSE 144
Query: 145 LHGEDMIVTPFAQVLASLRTVRSNVAALARQQCLGAAKQGPVGNPSSSNQLPPAEDTGQK 204
H ED+IVTPFAQVLASLR+VRSN + L + + K+ P+G P+ + +E+T Q+
Sbjct: 145 AHAEDLIVTPFAQVLASLRSVRSNFSLLTNVP-VPSNKRSPLGGPTPVCKATLSEETCQQ 203
Query: 205 LALETLDELDWCLDQLETLQTRHSVGEMASNKFKRILNRELTHLSETSRSGNQVSEYISR 264
LA ETL+ELDWCL+QLET+QT SV EMAS+KFKR+LNRELTHLSE SRSGNQVSEYIS
Sbjct: 204 LARETLEELDWCLEQLETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRSGNQVSEYIST 263
Query: 265 TFLDQQTEVELPKVTAEE-----AP---------------QPMSRISGLHGLCHSASLSS 304
TFLD+Q EVE+P T +E AP QPMS+I+GL L HS SL++
Sbjct: 264 TFLDKQNEVEIPSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLKKLMHSNSLNN 323
Query: 305 ATVPRFGVQTDQEEQLAKELEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLLKTFQ 364
+ +PRFGV+TDQEE LA+ELE+ NKWGL++F V++ +G R LT I++ IFQERDLLK F+
Sbjct: 324 SNIPRFGVKTDQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFR 383
Query: 365 IPADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFA 424
IP DT+ TY+L LE HYHA+VAYHNSLHAADV QSTHVLLATPAL+AVFTDLEILAALFA
Sbjct: 384 IPVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFA 443
Query: 425 SAIHDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAENCDIFQNLSAKQ 484
+AIHDVDHPGVSNQFLINTNSELALMYND SVLENHHLAVGFKLLQ +NCDIFQNLS +Q
Sbjct: 444 AAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQ 503
Query: 485 RLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQNLVHC 544
R SLR+MVIDMVLATDMSKHM LLADLKTMVETKKVTS GVLLLDNYSDRIQVL+N+VHC
Sbjct: 504 RQSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHC 563
Query: 545 ADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVGFIDYI 604
ADLSNPTKPL LYRQWTDRIMAEFFQQGDRERE G++ISPMCDKHTASVEKSQVGFIDYI
Sbjct: 564 ADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYI 623
Query: 605 AHPLWETWADLVHPDAQDLLDTLEDNREWYQSKIPRSPSDLTNPERDG------PDRFQF 658
HPLWETWADLVHPDAQ++LDTLEDNR+WY S I +SPS E G PD+FQF
Sbjct: 624 VHPLWETWADLVHPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEESRGPGHPPLPDKFQF 683
Query: 659 ELTLEEAEEEDEEEEEEGEETALAKEAL 686
ELTL EEE+EEE + A+EAL
Sbjct: 684 ELTL---EEEEEEEISMAQIPCTAQEAL 708
>gi|82799486 phosphodiesterase 4B isoform 1 [Homo sapiens]
Length = 736
Score = 852 bits (2202), Expect = 0.0
Identities = 436/621 (70%), Positives = 511/621 (82%), Gaps = 11/621 (1%)
Query: 82 FDLENGLSCGRRALDPQSSPGLGRIMQAPVP-HSQRRESFLYRSDSDYELSPKAMSRNSS 140
FD+ENG S GR LDPQ+S G ++ A P HSQRRESFLYRSDSDY+LSPKAMSRNSS
Sbjct: 95 FDVENGPSPGRSPLDPQASSSAGLVLHATFPGHSQRRESFLYRSDSDYDLSPKAMSRNSS 154
Query: 141 VASDLHGEDMIVTPFAQVLASLRTVRSNVAALARQQCLGAAKQGPVGNPSSSNQLPPAED 200
+ S+ HG+D+IVTPFAQVLASLR+VR+N L + K+ P + +++ P E+
Sbjct: 155 LPSEQHGDDLIVTPFAQVLASLRSVRNNFTILTNLHGT-SNKRSPAASQPPVSRVNPQEE 213
Query: 201 TGQKLALETLDELDWCLDQLETLQTRHSVGEMASNKFKRILNRELTHLSETSRSGNQVSE 260
+ QKLA+ETL+ELDWCLDQLET+QT SV EMASNKFKR+LNRELTHLSE SRSGNQVSE
Sbjct: 214 SYQKLAMETLEELDWCLDQLETIQTYRSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSE 273
Query: 261 YISRTFLDQQTEVELPKVTAEEAP-----QPMSRISGLHGLCHSASLSSATVPRFGVQTD 315
YIS TFLD+Q +VE+P T ++ Q M++ISG+ L HS+SL++ ++ RFGV T+
Sbjct: 274 YISNTFLDKQNDVEIPSPTQKDREKKKKQQLMTQISGVKKLMHSSSLNNTSISRFGVNTE 333
Query: 316 QEEQLAKELEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLLKTFQIPADTLATYLL 375
E+ LAKELED NKWGL++F VA S NRPLT I+++IFQERDLLKTF+I +DT TY++
Sbjct: 334 NEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMM 393
Query: 376 MLEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAIHDVDHPGV 435
LE HYH++VAYHNSLHAADVAQSTHVLL+TPAL+AVFTDLEILAA+FA+AIHDVDHPGV
Sbjct: 394 TLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGV 453
Query: 436 SNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAENCDIFQNLSAKQRLSLRRMVIDM 495
SNQFLINTNSELALMYND SVLENHHLAVGFKLLQ E+CDIF NL+ KQR +LR+MVIDM
Sbjct: 454 SNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDM 513
Query: 496 VLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQNLVHCADLSNPTKPLP 555
VLATDMSKHM+LLADLKTMVETKKVTS GVLLLDNY+DRIQVL+N+VHCADLSNPTK L
Sbjct: 514 VLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLE 573
Query: 556 LYRQWTDRIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVGFIDYIAHPLWETWADL 615
LYRQWTDRIM EFFQQGD+ERE G++ISPMCDKHTASVEKSQVGFIDYI HPLWETWADL
Sbjct: 574 LYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADL 633
Query: 616 VHPDAQDLLDTLEDNREWYQSKIPRSPS---DLTNPERDG-PDRFQFELTLEEAEEEDEE 671
V PDAQD+LDTLEDNR WYQS IP+SPS D N + G ++FQFELTL+E + E E
Sbjct: 634 VQPDAQDILDTLEDNRNWYQSMIPQSPSPPLDEQNRDCQGLMEKFQFELTLDEEDSEGPE 693
Query: 672 EEEEGEETALAKEALELPDTE 692
+E EG + + L + D E
Sbjct: 694 KEGEGHSYFSSTKTLCVIDPE 714
>gi|32171241 phosphodiesterase 4B isoform 1 [Homo sapiens]
Length = 736
Score = 852 bits (2202), Expect = 0.0
Identities = 436/621 (70%), Positives = 511/621 (82%), Gaps = 11/621 (1%)
Query: 82 FDLENGLSCGRRALDPQSSPGLGRIMQAPVP-HSQRRESFLYRSDSDYELSPKAMSRNSS 140
FD+ENG S GR LDPQ+S G ++ A P HSQRRESFLYRSDSDY+LSPKAMSRNSS
Sbjct: 95 FDVENGPSPGRSPLDPQASSSAGLVLHATFPGHSQRRESFLYRSDSDYDLSPKAMSRNSS 154
Query: 141 VASDLHGEDMIVTPFAQVLASLRTVRSNVAALARQQCLGAAKQGPVGNPSSSNQLPPAED 200
+ S+ HG+D+IVTPFAQVLASLR+VR+N L + K+ P + +++ P E+
Sbjct: 155 LPSEQHGDDLIVTPFAQVLASLRSVRNNFTILTNLHGT-SNKRSPAASQPPVSRVNPQEE 213
Query: 201 TGQKLALETLDELDWCLDQLETLQTRHSVGEMASNKFKRILNRELTHLSETSRSGNQVSE 260
+ QKLA+ETL+ELDWCLDQLET+QT SV EMASNKFKR+LNRELTHLSE SRSGNQVSE
Sbjct: 214 SYQKLAMETLEELDWCLDQLETIQTYRSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSE 273
Query: 261 YISRTFLDQQTEVELPKVTAEEAP-----QPMSRISGLHGLCHSASLSSATVPRFGVQTD 315
YIS TFLD+Q +VE+P T ++ Q M++ISG+ L HS+SL++ ++ RFGV T+
Sbjct: 274 YISNTFLDKQNDVEIPSPTQKDREKKKKQQLMTQISGVKKLMHSSSLNNTSISRFGVNTE 333
Query: 316 QEEQLAKELEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLLKTFQIPADTLATYLL 375
E+ LAKELED NKWGL++F VA S NRPLT I+++IFQERDLLKTF+I +DT TY++
Sbjct: 334 NEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMM 393
Query: 376 MLEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAIHDVDHPGV 435
LE HYH++VAYHNSLHAADVAQSTHVLL+TPAL+AVFTDLEILAA+FA+AIHDVDHPGV
Sbjct: 394 TLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGV 453
Query: 436 SNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAENCDIFQNLSAKQRLSLRRMVIDM 495
SNQFLINTNSELALMYND SVLENHHLAVGFKLLQ E+CDIF NL+ KQR +LR+MVIDM
Sbjct: 454 SNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDM 513
Query: 496 VLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQNLVHCADLSNPTKPLP 555
VLATDMSKHM+LLADLKTMVETKKVTS GVLLLDNY+DRIQVL+N+VHCADLSNPTK L
Sbjct: 514 VLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLE 573
Query: 556 LYRQWTDRIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVGFIDYIAHPLWETWADL 615
LYRQWTDRIM EFFQQGD+ERE G++ISPMCDKHTASVEKSQVGFIDYI HPLWETWADL
Sbjct: 574 LYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADL 633
Query: 616 VHPDAQDLLDTLEDNREWYQSKIPRSPS---DLTNPERDG-PDRFQFELTLEEAEEEDEE 671
V PDAQD+LDTLEDNR WYQS IP+SPS D N + G ++FQFELTL+E + E E
Sbjct: 634 VQPDAQDILDTLEDNRNWYQSMIPQSPSPPLDEQNRDCQGLMEKFQFELTLDEEDSEGPE 693
Query: 672 EEEEGEETALAKEALELPDTE 692
+E EG + + L + D E
Sbjct: 694 KEGEGHSYFSSTKTLCVIDPE 714
>gi|162329612 phosphodiesterase 4A isoform 3 [Homo sapiens]
Length = 825
Score = 850 bits (2197), Expect = 0.0
Identities = 447/633 (70%), Positives = 511/633 (80%), Gaps = 34/633 (5%)
Query: 82 FDLENGL--SCGRRALDPQSSPGLGRIMQAPVPHSQRRESFLYRSDSDYELSPKAMSRNS 139
F+ ENG S GR LD Q+SPGL ++ A SQRRESFLYRSDSDY++SPK MSRNS
Sbjct: 47 FEAENGPTPSPGRSPLDSQASPGL--VLHAGAATSQRRESFLYRSDSDYDMSPKTMSRNS 104
Query: 140 SVASDLHGEDMIVTPFAQVLASLRTVRSNVAALARQQCLGAAKQGPVGNPSSSNQLPPAE 199
SV S+ H ED+IVTPFAQVLASLR+VRSN + L + + K+ P+G P+ + +E
Sbjct: 105 SVTSEAHAEDLIVTPFAQVLASLRSVRSNFSLLTNVP-VPSNKRSPLGGPTPVCKATLSE 163
Query: 200 DTGQKLALETLDELDWCLDQLETLQTRHSVGEMASNKFKRILNRELTHLSETSRSGNQVS 259
+T Q+LA ETL+ELDWCL+QLET+QT SV EMAS+KFKR+LNRELTHLSE SRSGNQVS
Sbjct: 164 ETCQQLARETLEELDWCLEQLETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRSGNQVS 223
Query: 260 EYISRTFLDQQTEVELPKVTAEE-----AP---------------QPMSRISGLHGLCHS 299
EYIS TFLD+Q EVE+P T +E AP QPMS+I+GL L HS
Sbjct: 224 EYISTTFLDKQNEVEIPSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLKKLMHS 283
Query: 300 ASLSSATVPRFGVQTDQEEQLAKELEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDL 359
SL+++ +PRFGV+TDQEE LA+ELE+ NKWGL++F V++ +G R LT I++ IFQERDL
Sbjct: 284 NSLNNSNIPRFGVKTDQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDL 343
Query: 360 LKTFQIPADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEIL 419
LK F+IP DT+ TY+L LE HYHA+VAYHNSLHAADV QSTHVLLATPAL+AVFTDLEIL
Sbjct: 344 LKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEIL 403
Query: 420 AALFASAIHDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAENCDIFQN 479
AALFA+AIHDVDHPGVSNQFLINTNSELALMYND SVLENHHLAVGFKLLQ +NCDIFQN
Sbjct: 404 AALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQN 463
Query: 480 LSAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQ 539
LS +QR SLR+MVIDMVLATDMSKHM LLADLKTMVETKKVTS GVLLLDNYSDRIQVL+
Sbjct: 464 LSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLR 523
Query: 540 NLVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVG 599
N+VHCADLSNPTKPL LYRQWTDRIMAEFFQQGDRERE G++ISPMCDKHTASVEKSQVG
Sbjct: 524 NMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVG 583
Query: 600 FIDYIAHPLWETWADLVHPDAQDLLDTLEDNREWYQSKIPRSPSDLTNPERDG------P 653
FIDYI HPLWETWADLVHPDAQ++LDTLEDNR+WY S I +SPS E G P
Sbjct: 584 FIDYIVHPLWETWADLVHPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEESRGPGHPPLP 643
Query: 654 DRFQFELTLEEAEEEDEEEEEEGEETALAKEAL 686
D+FQFELTL EEE+EEE + A+EAL
Sbjct: 644 DKFQFELTL---EEEEEEEISMAQIPCTAQEAL 673
>gi|82799482 phosphodiesterase 4B isoform 2 [Homo sapiens]
Length = 564
Score = 735 bits (1897), Expect = 0.0
Identities = 373/516 (72%), Positives = 432/516 (83%), Gaps = 12/516 (2%)
Query: 189 PSSSNQLPP---AEDTGQKLALETLDELDWCLDQLETLQTRHSVGEMASNKFKRILNREL 245
P N +P AE++ QKLA+ETL+ELDWCLDQLET+QT SV EMASNKFKR+LNREL
Sbjct: 27 PLQPNYMPVCLFAEESYQKLAMETLEELDWCLDQLETIQTYRSVSEMASNKFKRMLNREL 86
Query: 246 THLSETSRSGNQVSEYISRTFLDQQTEVELPKVTAEEAP-----QPMSRISGLHGLCHSA 300
THLSE SRSGNQVSEYIS TFLD+Q +VE+P T ++ Q M++ISG+ L HS+
Sbjct: 87 THLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKKKQQLMTQISGVKKLMHSS 146
Query: 301 SLSSATVPRFGVQTDQEEQLAKELEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLL 360
SL++ ++ RFGV T+ E+ LAKELED NKWGL++F VA S NRPLT I+++IFQERDLL
Sbjct: 147 SLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLL 206
Query: 361 KTFQIPADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILA 420
KTF+I +DT TY++ LE HYH++VAYHNSLHAADVAQSTHVLL+TPAL+AVFTDLEILA
Sbjct: 207 KTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILA 266
Query: 421 ALFASAIHDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAENCDIFQNL 480
A+FA+AIHDVDHPGVSNQFLINTNSELALMYND SVLENHHLAVGFKLLQ E+CDIF NL
Sbjct: 267 AIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFMNL 326
Query: 481 SAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQN 540
+ KQR +LR+MVIDMVLATDMSKHM+LLADLKTMVETKKVTS GVLLLDNY+DRIQVL+N
Sbjct: 327 TKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRN 386
Query: 541 LVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVGF 600
+VHCADLSNPTK L LYRQWTDRIM EFFQQGD+ERE G++ISPMCDKHTASVEKSQVGF
Sbjct: 387 MVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGF 446
Query: 601 IDYIAHPLWETWADLVHPDAQDLLDTLEDNREWYQSKIPRSPS---DLTNPERDG-PDRF 656
IDYI HPLWETWADLV PDAQD+LDTLEDNR WYQS IP+SPS D N + G ++F
Sbjct: 447 IDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSPSPPLDEQNRDCQGLMEKF 506
Query: 657 QFELTLEEAEEEDEEEEEEGEETALAKEALELPDTE 692
QFELTL+E + E E+E EG + + L + D E
Sbjct: 507 QFELTLDEEDSEGPEKEGEGHSYFSSTKTLCVIDPE 542
>gi|5453862 phosphodiesterase 4A isoform 4 [Homo sapiens]
Length = 647
Score = 688 bits (1775), Expect = 0.0
Identities = 354/478 (74%), Positives = 397/478 (83%), Gaps = 29/478 (6%)
Query: 235 NKFKRILNRELTHLSETSRSGNQVSEYISRTFLDQQTEVELPKVTAEE-----AP----- 284
++FKR+LNRELTHLSE SRSGNQVSEYIS TFLD+Q EVE+P T +E AP
Sbjct: 21 DQFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVEIPSPTMKEREKQQAPRPRPS 80
Query: 285 ----------QPMSRISGLHGLCHSASLSSATVPRFGVQTDQEEQLAKELEDTNKWGLDV 334
QPMS+I+GL L HS SL+++ +PRFGV+TDQEE LA+ELE+ NKWGL++
Sbjct: 81 QPPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKTDQEELLAQELENLNKWGLNI 140
Query: 335 FKVAELSGNRPLTAIIFSIFQERDLLKTFQIPADTLATYLLMLEGHYHANVAYHNSLHAA 394
F V++ +G R LT I++ IFQERDLLK F+IP DT+ TY+L LE HYHA+VAYHNSLHAA
Sbjct: 141 FCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAA 200
Query: 395 DVAQSTHVLLATPALEAVFTDLEILAALFASAIHDVDHPGVSNQFLINTNSELALMYNDA 454
DV QSTHVLLATPAL+AVFTDLEILAALFA+AIHDVDHPGVSNQFLINTNSELALMYND
Sbjct: 201 DVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDE 260
Query: 455 SVLENHHLAVGFKLLQAENCDIFQNLSAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTM 514
SVLENHHLAVGFKLLQ +NCDIFQNLS +QR SLR+MVIDMVLATDMSKHM LLADLKTM
Sbjct: 261 SVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTM 320
Query: 515 VETKKVTSLGVLLLDNYSDRIQVLQNLVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDR 574
VETKKVTS GVLLLDNYSDRIQVL+N+VHCADLSNPTKPL LYRQWTDRIMAEFFQQGDR
Sbjct: 321 VETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDR 380
Query: 575 ERESGLDISPMCDKHTASVEKSQVGFIDYIAHPLWETWADLVHPDAQDLLDTLEDNREWY 634
ERE G++ISPMCDKHTASVEKSQVGFIDYI HPLWETWADLVHPDAQ++LDTLEDNR+WY
Sbjct: 381 ERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPDAQEILDTLEDNRDWY 440
Query: 635 QSKIPRSPSDLTNPERDG------PDRFQFELTLEEAEEEDEEEEEEGEETALAKEAL 686
S I +SPS E G PD+FQFELTL EEE+EEE + A+EAL
Sbjct: 441 YSAIRQSPSPPPEEESRGPGHPPLPDKFQFELTL---EEEEEEEISMAQIPCTAQEAL 495
>gi|4505677 phosphodiesterase 1B [Homo sapiens]
Length = 536
Score = 238 bits (607), Expect = 1e-62
Identities = 134/383 (34%), Positives = 213/383 (55%), Gaps = 16/383 (4%)
Query: 324 LEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLLKTFQIPADTLATYLLMLE-GHYH 382
L++ + W DVF + + + + L I+F + +L+ F+IP L ++L LE G+
Sbjct: 158 LKNLDLWCFDVFSLNQAADDHALRTIVFELLTRHNLISRFKIPTVFLMSFLDALETGYGK 217
Query: 383 ANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAIHDVDHPGVSNQFLIN 442
YHN +HAADV Q+ H L + +++E+LA +FA+AIHD +H G +N F I
Sbjct: 218 YKNPYHNQIHAADVTQTVHCFLLRTGMVHCLSEIELLAIIFAAAIHDYEHTGTTNSFHIQ 277
Query: 443 TNSELALMYNDASVLENHHLAVGFKLLQAENCDIFQNLSAKQRLSLRRMVIDMVLATDMS 502
T SE A++YND SVLENHH++ F+L+Q + +IF NL+ + + LR +VI+MVLATDMS
Sbjct: 278 TKSECAIVYNDRSVLENHHISSVFRLMQDDEMNIFINLTKDEFVELRALVIEMVLATDMS 337
Query: 503 KHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQNLVHCADLSNPTKPLPLYRQWTD 562
H + +KT ++ + D+ + L L+H AD+S+PTK ++ +WT
Sbjct: 338 CHFQQVKTMKTALQQLE-----------RIDKPKALSLLLHAADISHPTKQWLVHSRWTK 386
Query: 563 RIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVGFIDYIAHPLWETWADLVHPDAQD 622
+M EFF+QGD+E E GL SP+CD+ + V +SQ+GFID+I P + D+ Q
Sbjct: 387 ALMEEFFRQGDKEAELGLPFSPLCDRTSTLVAQSQIGFIDFIVEPTFSVLTDVAEKSVQP 446
Query: 623 LLDTLEDNREWYQSKIP-RSPSDLTNPERDGPDRFQFELTLEEAEEEDEEEEEEGEETAL 681
L D ED++ Q R PS PD F T + +E++++ +E + +
Sbjct: 447 LAD--EDSKSKNQPSFQWRQPSLDVEVGDPNPDVVSFRSTWVKRIQENKQKWKERAASGI 504
Query: 682 AKEALELPDTELLSPEAGPDPGD 704
+ + + + EA P P +
Sbjct: 505 TNQ-MSIDELSPCEEEAPPSPAE 526
>gi|51102295 phosphodiesterase 1A isoform 2 [Homo sapiens]
Length = 535
Score = 234 bits (596), Expect = 3e-61
Identities = 130/366 (35%), Positives = 204/366 (55%), Gaps = 17/366 (4%)
Query: 250 ETSRSGNQVSEYISRTFLDQQTEVELPKVTAEEAPQPMSRISGLHGLCHSASLSSATVPR 309
+T ++V ++++ TF ++ + K EE P+ S + + + T
Sbjct: 85 QTDSVPSEVRDWLASTFT---RKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHM 141
Query: 310 FGVQTDQEEQLAKELEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLLKTFQIPADT 369
G+ + L+D +KW DVF + E SG L +I+ +F DL+ F+IP
Sbjct: 142 VGLA--YPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSC 199
Query: 370 LATYLLMLE-GHYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAIH 428
L T+ LE G+ YHN +HAADV Q+ H ++ + T+LEILA +FA+AIH
Sbjct: 200 LITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIH 259
Query: 429 DVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAENCDIFQNLSAKQRLSL 488
D +H G +N F I T S++A++YND SVLENHH++ ++L+Q E +I NLS L
Sbjct: 260 DYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDL 319
Query: 489 RRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQNLVHCADLS 548
R +VI+MVL+TDMS H + +++ ++ + G+ DR + + ++H AD+S
Sbjct: 320 RNLVIEMVLSTDMSGHFQQIKNIRNSLQQPE----GI-------DRAKTMSLILHAADIS 368
Query: 549 NPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVGFIDYIAHPL 608
+P K L+ +WT +M EFF QGD+E E GL SP+CD+ + V +SQ+GFID+I P
Sbjct: 369 HPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPT 428
Query: 609 WETWAD 614
+ D
Sbjct: 429 FSLLTD 434
>gi|21361262 phosphodiesterase 1A isoform 1 [Homo sapiens]
Length = 545
Score = 234 bits (596), Expect = 3e-61
Identities = 130/366 (35%), Positives = 204/366 (55%), Gaps = 17/366 (4%)
Query: 250 ETSRSGNQVSEYISRTFLDQQTEVELPKVTAEEAPQPMSRISGLHGLCHSASLSSATVPR 309
+T ++V ++++ TF ++ + K EE P+ S + + + T
Sbjct: 85 QTDSVPSEVRDWLASTFT---RKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHM 141
Query: 310 FGVQTDQEEQLAKELEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLLKTFQIPADT 369
G+ + L+D +KW DVF + E SG L +I+ +F DL+ F+IP
Sbjct: 142 VGLA--YPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSC 199
Query: 370 LATYLLMLE-GHYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAIH 428
L T+ LE G+ YHN +HAADV Q+ H ++ + T+LEILA +FA+AIH
Sbjct: 200 LITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIH 259
Query: 429 DVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAENCDIFQNLSAKQRLSL 488
D +H G +N F I T S++A++YND SVLENHH++ ++L+Q E +I NLS L
Sbjct: 260 DYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDL 319
Query: 489 RRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQNLVHCADLS 548
R +VI+MVL+TDMS H + +++ ++ + G+ DR + + ++H AD+S
Sbjct: 320 RNLVIEMVLSTDMSGHFQQIKNIRNSLQQPE----GI-------DRAKTMSLILHAADIS 368
Query: 549 NPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVGFIDYIAHPL 608
+P K L+ +WT +M EFF QGD+E E GL SP+CD+ + V +SQ+GFID+I P
Sbjct: 369 HPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPT 428
Query: 609 WETWAD 614
+ D
Sbjct: 429 FSLLTD 434
>gi|4826894 phosphodiesterase 1C [Homo sapiens]
Length = 634
Score = 229 bits (585), Expect = 5e-60
Identities = 123/305 (40%), Positives = 178/305 (58%), Gaps = 15/305 (4%)
Query: 324 LEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLLKTFQIPADTLATYLLMLEGHY-- 381
L+D +KW DVF + E SG+ L I + + DL+ F+IP L +++ LE Y
Sbjct: 163 LKDVDKWSFDVFSLNEASGDHALKFIFYELLTRYDLISRFKIPISALVSFVEALEVGYSK 222
Query: 382 HANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAIHDVDHPGVSNQFLI 441
H N YHN +HAADV Q+ H LL + T+LEI A +F++AIHD +H G +N F I
Sbjct: 223 HKN-PYHNLMHAADVTQTVHYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGTTNNFHI 281
Query: 442 NTNSELALMYNDASVLENHHLAVGFKLLQ-AENCDIFQNLSAKQRLSLRRMVIDMVLATD 500
T S+ A++YND SVLENHHL+ ++LLQ E +I NLS R +VI+MV+ATD
Sbjct: 282 QTRSDPAILYNDRSVLENHHLSAAYRLLQDDEEMNILINLSKDDWREFRTLVIEMVMATD 341
Query: 501 MSKHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQNLVHCADLSNPTKPLPLYRQW 560
MS H + +KT ++ + ++ + L ++H AD+S+P K L+ +W
Sbjct: 342 MSCHFQQIKAMKTALQQPEAI-----------EKPKALSLMLHTADISHPAKAWDLHHRW 390
Query: 561 TDRIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVGFIDYIAHPLWETWADLVHPDA 620
T ++ EFF+QGDRE E GL SP+CD+ + V +SQVGFID+I P + D+
Sbjct: 391 TMSLLEEFFRQGDREAELGLPFSPLCDRKSTMVAQSQVGFIDFIVEPTFTVLTDMTEKIV 450
Query: 621 QDLLD 625
L+D
Sbjct: 451 SPLID 455
>gi|47132537 phosphodiesterase 8A isoform 2 [Homo sapiens]
Length = 783
Score = 224 bits (570), Expect = 3e-58
Identities = 119/334 (35%), Positives = 194/334 (58%), Gaps = 15/334 (4%)
Query: 315 DQEEQLAKELEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLLKTFQIPADTLATYL 374
D ++A+ +E+ W D+F++ + NRPL + +F + + TL ++L
Sbjct: 437 DVPPRIARAMENEEYWDFDIFELEAATHNRPLIYLGLKMFARFGICEFLHCSESTLRSWL 496
Query: 375 LMLEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAIHDVDHPG 434
++E +YH++ YHNS H+ADV +T L+ ++ ++ +AAL A+ IHDVDHPG
Sbjct: 497 QIIEANYHSSNPYHNSTHSADVLHATAYFLSKERIKETLDPIDEVAALIAATIHDVDHPG 556
Query: 435 VSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAEN-CDIFQNLSAKQRLSLRRMVI 493
+N FL N SELA++YND +VLE+HH A+ F+L ++ C+IF+N+ +LR+ +I
Sbjct: 557 RTNSFLCNAGSELAILYNDTAVLESHHAALAFQLTTGDDKCNIFKNMERNDYRTLRQGII 616
Query: 494 DMVLATDMSKHM-----------NLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQNLV 542
DMVLAT+M+KH LA L+ ET K + +L +R + + L+
Sbjct: 617 DMVLATEMTKHFEHVNKFVNSINKPLATLEENGETDKNQEVINTMLRTPENRTLIKRMLI 676
Query: 543 HCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLD-ISPMCDKHTASVEKSQVGFI 601
CAD+SNP +PL +W RI E+F Q D E++ GL + P+ D++T S+ KSQ+ FI
Sbjct: 677 KCADVSNPCRPLQYCIEWAARISEEYFSQTDEEKQQGLPVVMPVFDRNTCSIPKSQISFI 736
Query: 602 DYIAHPLWETWADLVHPDAQDLLDTLEDNREWYQ 635
DY +++ W V D DL+ L++N ++++
Sbjct: 737 DYFITDMFDAWDAFV--DLPDLMQHLDNNFKYWK 768
>gi|27734721 phosphodiesterase 8A isoform 1 [Homo sapiens]
Length = 829
Score = 224 bits (570), Expect = 3e-58
Identities = 119/334 (35%), Positives = 194/334 (58%), Gaps = 15/334 (4%)
Query: 315 DQEEQLAKELEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLLKTFQIPADTLATYL 374
D ++A+ +E+ W D+F++ + NRPL + +F + + TL ++L
Sbjct: 483 DVPPRIARAMENEEYWDFDIFELEAATHNRPLIYLGLKMFARFGICEFLHCSESTLRSWL 542
Query: 375 LMLEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAIHDVDHPG 434
++E +YH++ YHNS H+ADV +T L+ ++ ++ +AAL A+ IHDVDHPG
Sbjct: 543 QIIEANYHSSNPYHNSTHSADVLHATAYFLSKERIKETLDPIDEVAALIAATIHDVDHPG 602
Query: 435 VSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAEN-CDIFQNLSAKQRLSLRRMVI 493
+N FL N SELA++YND +VLE+HH A+ F+L ++ C+IF+N+ +LR+ +I
Sbjct: 603 RTNSFLCNAGSELAILYNDTAVLESHHAALAFQLTTGDDKCNIFKNMERNDYRTLRQGII 662
Query: 494 DMVLATDMSKHM-----------NLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQNLV 542
DMVLAT+M+KH LA L+ ET K + +L +R + + L+
Sbjct: 663 DMVLATEMTKHFEHVNKFVNSINKPLATLEENGETDKNQEVINTMLRTPENRTLIKRMLI 722
Query: 543 HCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLD-ISPMCDKHTASVEKSQVGFI 601
CAD+SNP +PL +W RI E+F Q D E++ GL + P+ D++T S+ KSQ+ FI
Sbjct: 723 KCADVSNPCRPLQYCIEWAARISEEYFSQTDEEKQQGLPVVMPVFDRNTCSIPKSQISFI 782
Query: 602 DYIAHPLWETWADLVHPDAQDLLDTLEDNREWYQ 635
DY +++ W V D DL+ L++N ++++
Sbjct: 783 DYFITDMFDAWDAFV--DLPDLMQHLDNNFKYWK 814
>gi|9506959 phosphodiesterase 7B [Homo sapiens]
Length = 450
Score = 213 bits (542), Expect = 5e-55
Identities = 122/396 (30%), Positives = 204/396 (51%), Gaps = 21/396 (5%)
Query: 287 MSRISGLHGLCHSASLSSATVPRFGVQTDQEEQLAKE---LEDTNKWGLDVFKVAELSGN 343
+ R+ H++ L +P+ + E+ L + L W D+F L+
Sbjct: 69 VKRLLSFQRYFHASRLLRGIIPQAPLHLLDEDYLGQARHMLSKVGMWDFDIFLFDRLTNG 128
Query: 344 RPLTAIIFSIFQERDLLKTFQIPADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVL 403
L ++ +F L+ F++ TL +L+M++ YH+ YHN++HAADV Q+ H
Sbjct: 129 NSLVTLLCHLFNTHGLIHHFKLDMVTLHRFLVMVQEDYHSQNPYHNAVHAADVTQAMHCY 188
Query: 404 LATPALEAVFTDLEILAALFASAIHDVDHPGVSNQFLINTNSELALMYNDASVLENHHLA 463
L P L + T L+I+ L A+A HDVDHPGV+ FLI TN LA +Y + SVLENHH
Sbjct: 189 LKEPKLASFLTPLDIMLGLLAAAAHDVDHPGVNQPFLIKTNHHLANLYQNMSVLENHHWR 248
Query: 464 VGFKLLQAENCDIFQNLSAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSL 523
+L+ + +L + + + + ++LATD+++ L LK + K
Sbjct: 249 STIGMLRESR--LLAHLPKEMTQDIEQQLGSLILATDINRQNEFLTRLKAHLHNKD---- 302
Query: 524 GVLLLDNYSDRIQVLQNLVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDIS 583
L L++ DR +LQ + CAD+ NP + + +QW++R+ EF++QG+ E++ L+IS
Sbjct: 303 --LRLEDAQDRHFMLQIALKCADICNPCRIWEMSKQWSERVCEEFYRQGELEQKFELEIS 360
Query: 584 PMCDKHTASVEKSQVGFIDYIAHPLWETWADLVHPD--AQDLLDTLEDNREWYQSKIPRS 641
P+C++ S+ Q+GF+ YI PL+ WA ++++L L N+ ++S +PR
Sbjct: 361 PLCNQQKDSIPSIQIGFMSYIVEPLFREWAHFTGNSTLSENMLGHLAHNKAQWKSLLPRQ 420
Query: 642 PSDLTNPERDGPDRFQFELTLEEAEEEDEEEEEEGE 677
GPD + A + E EE+EG+
Sbjct: 421 HRS-RGSSGSGPDH-------DHAGQGTESEEQEGD 448
>gi|71164875 phosphodiesterase 8B isoform 2 [Homo sapiens]
Length = 838
Score = 209 bits (532), Expect = 7e-54
Identities = 115/340 (33%), Positives = 189/340 (55%), Gaps = 17/340 (5%)
Query: 320 LAKELEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLLKTFQIPADTLATYLLMLEG 379
+++ L++ W ++F++ ++ RPL + +F + + TL + ++E
Sbjct: 500 ISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWFQVIEA 559
Query: 380 HYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAIHDVDHPGVSNQF 439
+YH++ AYHNS HAADV +T L ++ L+ +AAL A+ +HDVDHPG +N F
Sbjct: 560 NYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPGRTNSF 619
Query: 440 LINTNSELALMYNDASVLENHHLAVGFKL-LQAENCDIFQNLSAKQRLSLRRMVIDMVLA 498
L N SELA++YND +VLE+HH A+ F+L ++ C+IF+N+ +LR+ +IDMVLA
Sbjct: 620 LCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAIIDMVLA 679
Query: 499 TDMSKHMNLLADLKTMVETKKVTSLGVLLLD------NY-SDRIQVLQNLVHCADLSNPT 551
T+M+KH + + + + N+ ++I + + ++ CAD++NP
Sbjct: 680 TEMTKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKCADVANPC 739
Query: 552 KPLPLYRQWTDRIMAEFFQQGDRERESGLD-ISPMCDKHTASVEKSQVGFIDYIAHPLWE 610
+PL L +W RI E+F Q D E+ GL + P+ D++T S+ KSQ+ FIDY +++
Sbjct: 740 RPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYFITDMFD 799
Query: 611 TWADLVHPDAQDLLDTLEDN-REW-----YQSKIPRSPSD 644
W H A L+ L DN + W + K R PSD
Sbjct: 800 AWDAFAHLPA--LMQHLADNYKHWKTLDDLKCKSLRLPSD 837
>gi|71164873 phosphodiesterase 8B isoform 4 [Homo sapiens]
Length = 865
Score = 209 bits (532), Expect = 7e-54
Identities = 115/340 (33%), Positives = 189/340 (55%), Gaps = 17/340 (5%)
Query: 320 LAKELEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLLKTFQIPADTLATYLLMLEG 379
+++ L++ W ++F++ ++ RPL + +F + + TL + ++E
Sbjct: 527 ISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWFQVIEA 586
Query: 380 HYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAIHDVDHPGVSNQF 439
+YH++ AYHNS HAADV +T L ++ L+ +AAL A+ +HDVDHPG +N F
Sbjct: 587 NYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPGRTNSF 646
Query: 440 LINTNSELALMYNDASVLENHHLAVGFKL-LQAENCDIFQNLSAKQRLSLRRMVIDMVLA 498
L N SELA++YND +VLE+HH A+ F+L ++ C+IF+N+ +LR+ +IDMVLA
Sbjct: 647 LCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAIIDMVLA 706
Query: 499 TDMSKHMNLLADLKTMVETKKVTSLGVLLLD------NY-SDRIQVLQNLVHCADLSNPT 551
T+M+KH + + + + N+ ++I + + ++ CAD++NP
Sbjct: 707 TEMTKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKCADVANPC 766
Query: 552 KPLPLYRQWTDRIMAEFFQQGDRERESGLD-ISPMCDKHTASVEKSQVGFIDYIAHPLWE 610
+PL L +W RI E+F Q D E+ GL + P+ D++T S+ KSQ+ FIDY +++
Sbjct: 767 RPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYFITDMFD 826
Query: 611 TWADLVHPDAQDLLDTLEDN-REW-----YQSKIPRSPSD 644
W H A L+ L DN + W + K R PSD
Sbjct: 827 AWDAFAHLPA--LMQHLADNYKHWKTLDDLKCKSLRLPSD 864
>gi|71164869 phosphodiesterase 8B isoform 5 [Homo sapiens]
Length = 830
Score = 209 bits (532), Expect = 7e-54
Identities = 115/340 (33%), Positives = 189/340 (55%), Gaps = 17/340 (5%)
Query: 320 LAKELEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLLKTFQIPADTLATYLLMLEG 379
+++ L++ W ++F++ ++ RPL + +F + + TL + ++E
Sbjct: 492 ISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWFQVIEA 551
Query: 380 HYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAIHDVDHPGVSNQF 439
+YH++ AYHNS HAADV +T L ++ L+ +AAL A+ +HDVDHPG +N F
Sbjct: 552 NYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPGRTNSF 611
Query: 440 LINTNSELALMYNDASVLENHHLAVGFKL-LQAENCDIFQNLSAKQRLSLRRMVIDMVLA 498
L N SELA++YND +VLE+HH A+ F+L ++ C+IF+N+ +LR+ +IDMVLA
Sbjct: 612 LCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAIIDMVLA 671
Query: 499 TDMSKHMNLLADLKTMVETKKVTSLGVLLLD------NY-SDRIQVLQNLVHCADLSNPT 551
T+M+KH + + + + N+ ++I + + ++ CAD++NP
Sbjct: 672 TEMTKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKCADVANPC 731
Query: 552 KPLPLYRQWTDRIMAEFFQQGDRERESGLD-ISPMCDKHTASVEKSQVGFIDYIAHPLWE 610
+PL L +W RI E+F Q D E+ GL + P+ D++T S+ KSQ+ FIDY +++
Sbjct: 732 RPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYFITDMFD 791
Query: 611 TWADLVHPDAQDLLDTLEDN-REW-----YQSKIPRSPSD 644
W H A L+ L DN + W + K R PSD
Sbjct: 792 AWDAFAHLPA--LMQHLADNYKHWKTLDDLKCKSLRLPSD 829
>gi|71164867 phosphodiesterase 8B isoform 3 [Homo sapiens]
Length = 788
Score = 209 bits (532), Expect = 7e-54
Identities = 115/340 (33%), Positives = 189/340 (55%), Gaps = 17/340 (5%)
Query: 320 LAKELEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLLKTFQIPADTLATYLLMLEG 379
+++ L++ W ++F++ ++ RPL + +F + + TL + ++E
Sbjct: 450 ISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWFQVIEA 509
Query: 380 HYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAIHDVDHPGVSNQF 439
+YH++ AYHNS HAADV +T L ++ L+ +AAL A+ +HDVDHPG +N F
Sbjct: 510 NYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPGRTNSF 569
Query: 440 LINTNSELALMYNDASVLENHHLAVGFKL-LQAENCDIFQNLSAKQRLSLRRMVIDMVLA 498
L N SELA++YND +VLE+HH A+ F+L ++ C+IF+N+ +LR+ +IDMVLA
Sbjct: 570 LCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAIIDMVLA 629
Query: 499 TDMSKHMNLLADLKTMVETKKVTSLGVLLLD------NY-SDRIQVLQNLVHCADLSNPT 551
T+M+KH + + + + N+ ++I + + ++ CAD++NP
Sbjct: 630 TEMTKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKCADVANPC 689
Query: 552 KPLPLYRQWTDRIMAEFFQQGDRERESGLD-ISPMCDKHTASVEKSQVGFIDYIAHPLWE 610
+PL L +W RI E+F Q D E+ GL + P+ D++T S+ KSQ+ FIDY +++
Sbjct: 690 RPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYFITDMFD 749
Query: 611 TWADLVHPDAQDLLDTLEDN-REW-----YQSKIPRSPSD 644
W H A L+ L DN + W + K R PSD
Sbjct: 750 AWDAFAHLPA--LMQHLADNYKHWKTLDDLKCKSLRLPSD 787
>gi|26006851 phosphodiesterase 8B isoform 1 [Homo sapiens]
Length = 885
Score = 209 bits (532), Expect = 7e-54
Identities = 115/340 (33%), Positives = 189/340 (55%), Gaps = 17/340 (5%)
Query: 320 LAKELEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLLKTFQIPADTLATYLLMLEG 379
+++ L++ W ++F++ ++ RPL + +F + + TL + ++E
Sbjct: 547 ISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWFQVIEA 606
Query: 380 HYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAIHDVDHPGVSNQF 439
+YH++ AYHNS HAADV +T L ++ L+ +AAL A+ +HDVDHPG +N F
Sbjct: 607 NYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPGRTNSF 666
Query: 440 LINTNSELALMYNDASVLENHHLAVGFKL-LQAENCDIFQNLSAKQRLSLRRMVIDMVLA 498
L N SELA++YND +VLE+HH A+ F+L ++ C+IF+N+ +LR+ +IDMVLA
Sbjct: 667 LCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAIIDMVLA 726
Query: 499 TDMSKHMNLLADLKTMVETKKVTSLGVLLLD------NY-SDRIQVLQNLVHCADLSNPT 551
T+M+KH + + + + N+ ++I + + ++ CAD++NP
Sbjct: 727 TEMTKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKCADVANPC 786
Query: 552 KPLPLYRQWTDRIMAEFFQQGDRERESGLD-ISPMCDKHTASVEKSQVGFIDYIAHPLWE 610
+PL L +W RI E+F Q D E+ GL + P+ D++T S+ KSQ+ FIDY +++
Sbjct: 787 RPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYFITDMFD 846
Query: 611 TWADLVHPDAQDLLDTLEDN-REW-----YQSKIPRSPSD 644
W H A L+ L DN + W + K R PSD
Sbjct: 847 AWDAFAHLPA--LMQHLADNYKHWKTLDDLKCKSLRLPSD 884
>gi|24429566 phosphodiesterase 7A isoform a [Homo sapiens]
Length = 456
Score = 208 bits (529), Expect = 2e-53
Identities = 108/299 (36%), Positives = 166/299 (55%), Gaps = 8/299 (2%)
Query: 315 DQEEQLAKELEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLLKTFQIPADTLATYL 374
D Q LE W D+F L+ L ++ F +F L++ F + L +L
Sbjct: 113 DYNGQAKCMLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFL 172
Query: 375 LMLEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAIHDVDHPG 434
+M++ YH+ YHN++HAADV Q+ H L P L T +IL +L A+A HD+DHPG
Sbjct: 173 VMIQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDILLSLIAAATHDLDHPG 232
Query: 435 VSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAENCDIFQNLSAKQRLSLRRMVID 494
V+ FLI TN LA +Y + SVLENHH LL+ +F +L + R + +
Sbjct: 233 VNQPFLIKTNHYLATLYKNTSVLENHHWRSAVGLLRESG--LFSHLPLESRQQMETQIGA 290
Query: 495 MVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQNLVHCADLSNPTKPL 554
++LATD+S+ L+ ++ ++ G L L++ R VLQ + CAD+ NP +
Sbjct: 291 LILATDISRQNEYLSLFRSHLDR------GDLCLEDTRHRHLVLQMALKCADICNPCRTW 344
Query: 555 PLYRQWTDRIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVGFIDYIAHPLWETWA 613
L +QW++++ EFF QGD E++ L +SP+CD+HT S+ Q+GF+ Y+ PL+ WA
Sbjct: 345 ELSKQWSEKVTEEFFHQGDIEKKYHLGVSPLCDRHTESIANIQIGFMTYLVEPLFTEWA 403
>gi|24429564 phosphodiesterase 7A isoform b [Homo sapiens]
Length = 424
Score = 194 bits (493), Expect = 2e-49
Identities = 103/290 (35%), Positives = 159/290 (54%), Gaps = 8/290 (2%)
Query: 315 DQEEQLAKELEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLLKTFQIPADTLATYL 374
D Q LE W D+F L+ L ++ F +F L++ F + L +L
Sbjct: 139 DYNGQAKCMLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFL 198
Query: 375 LMLEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAIHDVDHPG 434
+M++ YH+ YHN++HAADV Q+ H L P L T +IL +L A+A HD+DHPG
Sbjct: 199 VMIQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDILLSLIAAATHDLDHPG 258
Query: 435 VSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAENCDIFQNLSAKQRLSLRRMVID 494
V+ FLI TN LA +Y + SVLENHH LL+ +F +L + R + +
Sbjct: 259 VNQPFLIKTNHYLATLYKNTSVLENHHWRSAVGLLRESG--LFSHLPLESRQQMETQIGA 316
Query: 495 MVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQNLVHCADLSNPTKPL 554
++LATD+S+ L+ ++ ++ G L L++ R VLQ + CAD+ NP +
Sbjct: 317 LILATDISRQNEYLSLFRSHLDR------GDLCLEDTRHRHLVLQMALKCADICNPCRTW 370
Query: 555 PLYRQWTDRIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVGFIDYI 604
L +QW++++ EFF QGD E++ L +SP+CD+HT S+ Q+G Y+
Sbjct: 371 ELSKQWSEKVTEEFFHQGDIEKKYHLGVSPLCDRHTESIANIQIGNYTYL 420
>gi|48762752 phosphodiesterase 9A isoform g [Homo sapiens]
Length = 386
Score = 171 bits (432), Expect = 3e-42
Identities = 88/283 (31%), Positives = 158/283 (55%), Gaps = 9/283 (3%)
Query: 353 IFQERDLLKTFQIPADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAV 412
++ + L++ F I TL +L + +Y N +HN H VAQ + ++ +L+
Sbjct: 71 MYHDLGLVRDFSINPVTLRRWLFCVHDNYRNN-PFHNFRHCFCVAQMMYSMVWLCSLQEK 129
Query: 413 FTDLEILAALFASAIHDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAE 472
F+ +IL + A+ HD+DHPG +N + IN +ELA+ YND S LENHH AV F++L
Sbjct: 130 FSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEP 189
Query: 473 NCDIFQNLSAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYS 532
C+IF N+ +R+ +I ++LATDM++H ++ K +E ++ + +
Sbjct: 190 ECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSN------EEHM 243
Query: 533 DRIQVLQNLVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISPMCDKHTAS 592
++++ L+ C D+SN +P+ + W D ++ E+F Q DRE+ GL ++P D+ +
Sbjct: 244 TLLKMI--LIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVT 301
Query: 593 VEKSQVGFIDYIAHPLWETWADLVHPDAQDLLDTLEDNREWYQ 635
+Q+GFI ++ P++ET L + +L L ++R+ Y+
Sbjct: 302 KATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYE 344
>gi|48762754 phosphodiesterase 9A isoform g [Homo sapiens]
Length = 386
Score = 171 bits (432), Expect = 3e-42
Identities = 88/283 (31%), Positives = 158/283 (55%), Gaps = 9/283 (3%)
Query: 353 IFQERDLLKTFQIPADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAV 412
++ + L++ F I TL +L + +Y N +HN H VAQ + ++ +L+
Sbjct: 71 MYHDLGLVRDFSINPVTLRRWLFCVHDNYRNN-PFHNFRHCFCVAQMMYSMVWLCSLQEK 129
Query: 413 FTDLEILAALFASAIHDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAE 472
F+ +IL + A+ HD+DHPG +N + IN +ELA+ YND S LENHH AV F++L
Sbjct: 130 FSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEP 189
Query: 473 NCDIFQNLSAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYS 532
C+IF N+ +R+ +I ++LATDM++H ++ K +E ++ + +
Sbjct: 190 ECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSN------EEHM 243
Query: 533 DRIQVLQNLVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISPMCDKHTAS 592
++++ L+ C D+SN +P+ + W D ++ E+F Q DRE+ GL ++P D+ +
Sbjct: 244 TLLKMI--LIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVT 301
Query: 593 VEKSQVGFIDYIAHPLWETWADLVHPDAQDLLDTLEDNREWYQ 635
+Q+GFI ++ P++ET L + +L L ++R+ Y+
Sbjct: 302 KATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYE 344
>gi|48762750 phosphodiesterase 9A isoform o [Homo sapiens]
Length = 567
Score = 171 bits (432), Expect = 3e-42
Identities = 88/283 (31%), Positives = 158/283 (55%), Gaps = 9/283 (3%)
Query: 353 IFQERDLLKTFQIPADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAV 412
++ + L++ F I TL +L + +Y N +HN H VAQ + ++ +L+
Sbjct: 252 MYHDLGLVRDFSINPVTLRRWLFCVHDNYRNN-PFHNFRHCFCVAQMMYSMVWLCSLQEK 310
Query: 413 FTDLEILAALFASAIHDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAE 472
F+ +IL + A+ HD+DHPG +N + IN +ELA+ YND S LENHH AV F++L
Sbjct: 311 FSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEP 370
Query: 473 NCDIFQNLSAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYS 532
C+IF N+ +R+ +I ++LATDM++H ++ K +E ++ + +
Sbjct: 371 ECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSN------EEHM 424
Query: 533 DRIQVLQNLVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISPMCDKHTAS 592
++++ L+ C D+SN +P+ + W D ++ E+F Q DRE+ GL ++P D+ +
Sbjct: 425 TLLKMI--LIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVT 482
Query: 593 VEKSQVGFIDYIAHPLWETWADLVHPDAQDLLDTLEDNREWYQ 635
+Q+GFI ++ P++ET L + +L L ++R+ Y+
Sbjct: 483 KATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYE 525
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.131 0.380
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 27,559,449
Number of Sequences: 37866
Number of extensions: 1305610
Number of successful extensions: 14457
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 191
Number of HSP's successfully gapped in prelim test: 102
Number of HSP's that attempted gapping in prelim test: 10933
Number of HSP's gapped (non-prelim): 1652
length of query: 712
length of database: 18,247,518
effective HSP length: 109
effective length of query: 603
effective length of database: 14,120,124
effective search space: 8514434772
effective search space used: 8514434772
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.