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Search of human proteins with 22902130
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|22902130 PTK7 protein tyrosine kinase 7 isoform d precursor
[Homo sapiens]
(1014 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|22902130 PTK7 protein tyrosine kinase 7 isoform d precursor [... 2066 0.0
gi|15826840 PTK7 protein tyrosine kinase 7 isoform a precursor [... 2027 0.0
gi|22902126 PTK7 protein tyrosine kinase 7 isoform b precursor [... 1922 0.0
gi|22902128 PTK7 protein tyrosine kinase 7 isoform c precursor [... 1617 0.0
gi|5031927 skeletal muscle receptor tyrosine kinase [Homo sapiens] 217 4e-56
gi|59889558 neurotrophic tyrosine kinase, receptor, type 1 isofo... 215 1e-55
gi|56118210 neurotrophic tyrosine kinase, receptor, type 1 isofo... 215 1e-55
gi|4585712 neurotrophic tyrosine kinase, receptor, type 1 isofor... 215 2e-55
gi|4503711 fibroblast growth factor receptor 3 isoform 1 precurs... 214 3e-55
gi|65506745 neurotrophic tyrosine kinase, receptor, type 2 isofo... 210 5e-54
gi|29029632 anaplastic lymphoma kinase [Homo sapiens] 210 5e-54
gi|221316639 fibroblast growth factor receptor 2 isoform 1 precu... 207 3e-53
gi|13186251 fibroblast growth factor receptor 1 isoform 2 precur... 207 3e-53
gi|105990522 fibroblast growth factor receptor 1 isoform 1 precu... 207 4e-53
gi|222144231 fibroblast growth factor receptor 2 isoform 3 precu... 206 7e-53
gi|221316638 fibroblast growth factor receptor 2 isoform 2 precu... 206 7e-53
gi|59889560 neurotrophic tyrosine kinase, receptor, type 3 isofo... 206 1e-52
gi|19924165 proto-oncogene c-ros-1 protein precursor [Homo sapiens] 204 3e-52
gi|222144241 fibroblast growth factor receptor 2 isoform 8 precu... 203 8e-52
gi|222144237 fibroblast growth factor receptor 2 isoform 6 precu... 202 2e-51
gi|222144235 fibroblast growth factor receptor 2 isoform 5 precu... 202 2e-51
gi|13186236 fibroblast growth factor receptor 1 isoform 4 precur... 201 3e-51
gi|13186234 fibroblast growth factor receptor 1 isoform 3 precur... 201 3e-51
gi|222144244 fibroblast growth factor receptor 2 isoform 9 precu... 201 4e-51
gi|59889562 neurotrophic tyrosine kinase, receptor, type 3 isofo... 201 4e-51
gi|42544153 leukocyte receptor tyrosine kinase isoform 1 precurs... 199 8e-51
gi|46249416 leukocyte receptor tyrosine kinase isoform 2 precurs... 199 8e-51
gi|4557665 insulin-like growth factor 1 receptor precursor [Homo... 197 4e-50
gi|21361306 neurotrophic tyrosine kinase, receptor, type 2 isofo... 197 5e-50
gi|119395738 insulin receptor isoform Short precursor [Homo sapi... 196 7e-50
>gi|22902130 PTK7 protein tyrosine kinase 7 isoform d precursor [Homo
sapiens]
Length = 1014
Score = 2066 bits (5352), Expect = 0.0
Identities = 1014/1014 (100%), Positives = 1014/1014 (100%)
Query: 1 MGAARGSPARPRRLPLLSVLLLPLLGGTQTAIVFIKQPSSQDALQGRRALLRCEVEAPGP 60
MGAARGSPARPRRLPLLSVLLLPLLGGTQTAIVFIKQPSSQDALQGRRALLRCEVEAPGP
Sbjct: 1 MGAARGSPARPRRLPLLSVLLLPLLGGTQTAIVFIKQPSSQDALQGRRALLRCEVEAPGP 60
Query: 61 VHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSGTFQCVARDDVTGEEARSANASFN 120
VHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSGTFQCVARDDVTGEEARSANASFN
Sbjct: 61 VHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSGTFQCVARDDVTGEEARSANASFN 120
Query: 121 IKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSS 180
IKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSS
Sbjct: 121 IKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSS 180
Query: 181 KERNLTLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVLAPQDVVVARYE 240
KERNLTLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVLAPQDVVVARYE
Sbjct: 181 KERNLTLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVLAPQDVVVARYE 240
Query: 241 EAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYR 300
EAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYR
Sbjct: 241 EAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYR 300
Query: 301 CIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFTAGSEERVTCLPPKGLPEPSVWWEHAG 360
CIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFTAGSEERVTCLPPKGLPEPSVWWEHAG
Sbjct: 301 CIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFTAGSEERVTCLPPKGLPEPSVWWEHAG 360
Query: 361 VRLPTHGRVYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVATVPSWLKKPQD 420
VRLPTHGRVYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVATVPSWLKKPQD
Sbjct: 361 VRLPTHGRVYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVATVPSWLKKPQD 420
Query: 421 SQLEEGKPGYLDCLTQATPKPTVVWYRNQMLISEDSRFEVFKNGTLRINSVEVYDGTWYR 480
SQLEEGKPGYLDCLTQATPKPTVVWYRNQMLISEDSRFEVFKNGTLRINSVEVYDGTWYR
Sbjct: 421 SQLEEGKPGYLDCLTQATPKPTVVWYRNQMLISEDSRFEVFKNGTLRINSVEVYDGTWYR 480
Query: 481 CMSSTPAGSIEAQARVQVLEKLKFTPPPQPQQCMEFDKEATVPCSATGREKPTIKWERAD 540
CMSSTPAGSIEAQARVQVLEKLKFTPPPQPQQCMEFDKEATVPCSATGREKPTIKWERAD
Sbjct: 481 CMSSTPAGSIEAQARVQVLEKLKFTPPPQPQQCMEFDKEATVPCSATGREKPTIKWERAD 540
Query: 541 GSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVAVFITFKVEPER 600
GSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVAVFITFKVEPER
Sbjct: 541 GSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVAVFITFKVEPER 600
Query: 601 TTVYQGHTALLQCEAQGDPKPLIQWKDKPVPEESEGPGSPPPYKMIQTIGLSVGAAVAYI 660
TTVYQGHTALLQCEAQGDPKPLIQWKDKPVPEESEGPGSPPPYKMIQTIGLSVGAAVAYI
Sbjct: 601 TTVYQGHTALLQCEAQGDPKPLIQWKDKPVPEESEGPGSPPPYKMIQTIGLSVGAAVAYI 660
Query: 661 IAVLGLMFYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQNGQPSAEIQEEVALTSLGSGP 720
IAVLGLMFYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQNGQPSAEIQEEVALTSLGSGP
Sbjct: 661 IAVLGLMFYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQNGQPSAEIQEEVALTSLGSGP 720
Query: 721 AATNKRHSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKD 780
AATNKRHSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKD
Sbjct: 721 AATNKRHSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKD 780
Query: 781 EQQQLDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDEK 840
EQQQLDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDEK
Sbjct: 781 EQQQLDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDEK 840
Query: 841 LKSQPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVY 900
LKSQPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVY
Sbjct: 841 LKSQPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVY 900
Query: 901 NSEYYHFRQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVL 960
NSEYYHFRQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVL
Sbjct: 901 NSEYYHFRQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVL 960
Query: 961 ADLQAGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASALGDSTVDSKP 1014
ADLQAGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASALGDSTVDSKP
Sbjct: 961 ADLQAGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASALGDSTVDSKP 1014
>gi|15826840 PTK7 protein tyrosine kinase 7 isoform a precursor [Homo
sapiens]
Length = 1070
Score = 2027 bits (5252), Expect = 0.0
Identities = 1010/1070 (94%), Positives = 1011/1070 (94%), Gaps = 56/1070 (5%)
Query: 1 MGAARGSPARPRRLPLLSVLLLPLLGGTQTAIVFIKQPSSQDALQGRRALLRCEVEAPGP 60
MGAARGSPARPRRLPLLSVLLLPLLGGTQTAIVFIKQPSSQDALQGRRALLRCEVEAPGP
Sbjct: 1 MGAARGSPARPRRLPLLSVLLLPLLGGTQTAIVFIKQPSSQDALQGRRALLRCEVEAPGP 60
Query: 61 VHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSGTFQCVARDDVTGEEARSANASFN 120
VHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSGTFQCVARDDVTGEEARSANASFN
Sbjct: 61 VHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSGTFQCVARDDVTGEEARSANASFN 120
Query: 121 IKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSS 180
IKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSS
Sbjct: 121 IKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSS 180
Query: 181 KERNLTLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVLAPQDVVVARYE 240
KERNLTLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVLAPQDVVVARYE
Sbjct: 181 KERNLTLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVLAPQDVVVARYE 240
Query: 241 EAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYR 300
EAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYR
Sbjct: 241 EAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYR 300
Query: 301 CIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFTAGSEERVTCLPPKGLPEPSVWWEHAG 360
CIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFTAGSEERVTCLPPKGLPEPSVWWEHAG
Sbjct: 301 CIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFTAGSEERVTCLPPKGLPEPSVWWEHAG 360
Query: 361 VRLPTHGRVYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVATVPSWLKKPQD 420
VRLPTHGRVYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVATVPSWLKKPQD
Sbjct: 361 VRLPTHGRVYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVATVPSWLKKPQD 420
Query: 421 SQLEEGKPGYLDCLTQATPKPTVVWYRNQMLISEDSRFEVFKNGTLRINSVEVYDGTWYR 480
SQLEEGKPGYLDCLTQATPKPTVVWYRNQMLISEDSRFEVFKNGTLRINSVEVYDGTWYR
Sbjct: 421 SQLEEGKPGYLDCLTQATPKPTVVWYRNQMLISEDSRFEVFKNGTLRINSVEVYDGTWYR 480
Query: 481 CMSSTPAGSIEAQARVQVLEKLKFTPPPQPQQCMEFDKEATVPCSATGREKPTIKWERAD 540
CMSSTPAGSIEAQARVQVLEKLKFTPPPQPQQCMEFDKEATVPCSATGREKPTIKWERAD
Sbjct: 481 CMSSTPAGSIEAQARVQVLEKLKFTPPPQPQQCMEFDKEATVPCSATGREKPTIKWERAD 540
Query: 541 GSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVAVFITFKVEPER 600
GSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVAVFITFKVEPER
Sbjct: 541 GSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVAVFITFKVEPER 600
Query: 601 TTVYQGHTALLQCEAQGDPKPLIQWKDKP-------------------------VPEES- 634
TTVYQGHTALLQCEAQGDPKPLIQWK K PE+S
Sbjct: 601 TTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPTKLGPRMHIFQNGSLVIHDVAPEDSG 660
Query: 635 ------------------------------EGPGSPPPYKMIQTIGLSVGAAVAYIIAVL 664
EGPGSPPPYKMIQTIGLSVGAAVAYIIAVL
Sbjct: 661 RYTCIAGNSCNIKHTEAPLYVVDKPVPEESEGPGSPPPYKMIQTIGLSVGAAVAYIIAVL 720
Query: 665 GLMFYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQNGQPSAEIQEEVALTSLGSGPAATN 724
GLMFYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQNGQPSAEIQEEVALTSLGSGPAATN
Sbjct: 721 GLMFYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQNGQPSAEIQEEVALTSLGSGPAATN 780
Query: 725 KRHSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQ 784
KRHSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQ
Sbjct: 781 KRHSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQ 840
Query: 785 LDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDEKLKSQ 844
LDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDEKLKSQ
Sbjct: 841 LDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDEKLKSQ 900
Query: 845 PLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEY 904
PLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEY
Sbjct: 901 PLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEY 960
Query: 905 YHFRQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQ 964
YHFRQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQ
Sbjct: 961 YHFRQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQ 1020
Query: 965 AGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASALGDSTVDSKP 1014
AGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASALGDSTVDSKP
Sbjct: 1021 AGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASALGDSTVDSKP 1070
>gi|22902126 PTK7 protein tyrosine kinase 7 isoform b precursor [Homo
sapiens]
Length = 1030
Score = 1922 bits (4978), Expect = 0.0
Identities = 970/1070 (90%), Positives = 971/1070 (90%), Gaps = 96/1070 (8%)
Query: 1 MGAARGSPARPRRLPLLSVLLLPLLGGTQTAIVFIKQPSSQDALQGRRALLRCEVEAPGP 60
MGAARGSPARPRRLPLLSVLLLPLLGGTQTAIVFIKQPSSQDALQGRRALLRCEVEAPGP
Sbjct: 1 MGAARGSPARPRRLPLLSVLLLPLLGGTQTAIVFIKQPSSQDALQGRRALLRCEVEAPGP 60
Query: 61 VHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSGTFQCVARDDVTGEEARSANASFN 120
VHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSGTFQCVARDDVTGEEARSANASFN
Sbjct: 61 VHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSGTFQCVARDDVTGEEARSANASFN 120
Query: 121 IKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSS 180
IKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSS
Sbjct: 121 IKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSS 180
Query: 181 KERNLTLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVLAPQDVVVARYE 240
KERNLTLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVLAPQDVVVARYE
Sbjct: 181 KERNLTLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVLAPQDVVVARYE 240
Query: 241 EAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYR 300
EAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYR
Sbjct: 241 EAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYR 300
Query: 301 CIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFTAGSEERVTCLPPKGLPEPSVWWEHAG 360
CIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFTAGSEERVTCLPPKGLPEPSVWWEHAG
Sbjct: 301 CIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFTAGSEERVTCLPPKGLPEPSVWWEHAG 360
Query: 361 VRLPTHGRVYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVATVPSWLKKPQD 420
VRLPTHGRVYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVATVPSWLKKPQD
Sbjct: 361 VRLPTHGRVYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVATVPSWLKKPQD 420
Query: 421 SQLEEGKPGYLDCLTQATPKPTVVWYRNQMLISEDSRFEVFKNGTLRINSVEVYDGTWYR 480
SQLEEGKPGYLDCLTQATPKPTVVWYRNQMLISEDSRFEVFKNGTLRINSVEVYDGTWYR
Sbjct: 421 SQLEEGKPGYLDCLTQATPKPTVVWYRNQMLISEDSRFEVFKNGTLRINSVEVYDGTWYR 480
Query: 481 CMSSTPAGSIEAQARVQVLEKLKFTPPPQPQQCMEFDKEATVPCSATGREKPTIKWERAD 540
CMSSTPAGSIEAQARVQVL D
Sbjct: 481 CMSSTPAGSIEAQARVQVL----------------------------------------D 500
Query: 541 GSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVAVFITFKVEPER 600
GSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVAVFITFKVEPER
Sbjct: 501 GSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVAVFITFKVEPER 560
Query: 601 TTVYQGHTALLQCEAQGDPKPLIQWKDKP-------------------------VPEES- 634
TTVYQGHTALLQCEAQGDPKPLIQWK K PE+S
Sbjct: 561 TTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPTKLGPRMHIFQNGSLVIHDVAPEDSG 620
Query: 635 ------------------------------EGPGSPPPYKMIQTIGLSVGAAVAYIIAVL 664
EGPGSPPPYKMIQTIGLSVGAAVAYIIAVL
Sbjct: 621 RYTCIAGNSCNIKHTEAPLYVVDKPVPEESEGPGSPPPYKMIQTIGLSVGAAVAYIIAVL 680
Query: 665 GLMFYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQNGQPSAEIQEEVALTSLGSGPAATN 724
GLMFYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQNGQPSAEIQEEVALTSLGSGPAATN
Sbjct: 681 GLMFYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQNGQPSAEIQEEVALTSLGSGPAATN 740
Query: 725 KRHSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQ 784
KRHSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQ
Sbjct: 741 KRHSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQ 800
Query: 785 LDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDEKLKSQ 844
LDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDEKLKSQ
Sbjct: 801 LDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDEKLKSQ 860
Query: 845 PLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEY 904
PLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEY
Sbjct: 861 PLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEY 920
Query: 905 YHFRQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQ 964
YHFRQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQ
Sbjct: 921 YHFRQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQ 980
Query: 965 AGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASALGDSTVDSKP 1014
AGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASALGDSTVDSKP
Sbjct: 981 AGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASALGDSTVDSKP 1030
>gi|22902128 PTK7 protein tyrosine kinase 7 isoform c precursor [Homo
sapiens]
Length = 940
Score = 1617 bits (4188), Expect = 0.0
Identities = 838/1023 (81%), Positives = 856/1023 (83%), Gaps = 92/1023 (8%)
Query: 1 MGAARGSPARPRRLPLLSVLLLPLLGGTQTAIVFIKQPSSQDALQGRRALLRCEVEAPGP 60
MGAARGSPARPRRLPLLSVLLLPLLGGTQTAIVFIKQPSSQDALQGRRALLRCEVEAPGP
Sbjct: 1 MGAARGSPARPRRLPLLSVLLLPLLGGTQTAIVFIKQPSSQDALQGRRALLRCEVEAPGP 60
Query: 61 VHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSGTFQCVARDDVTGEEARSANASFN 120
VHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSGTFQCVARDDVTGEEARSANASFN
Sbjct: 61 VHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSGTFQCVARDDVTGEEARSANASFN 120
Query: 121 IKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSS 180
IKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSS
Sbjct: 121 IKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSS 180
Query: 181 KERNLTLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVLAPQDVVVARYE 240
KERNLTLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVLAPQDVVVARYE
Sbjct: 181 KERNLTLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVLAPQDVVVARYE 240
Query: 241 EAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYR 300
EAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYR
Sbjct: 241 EAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYR 300
Query: 301 CIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFTAGSEERVTCLPPKGLPEPSVWWEHAG 360
CIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFTAGSEERVTCLPPKGLPEPSVWWEHAG
Sbjct: 301 CIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFTAGSEERVTCLPPKGLPEPSVWWEHAG 360
Query: 361 VRLPTHGRVYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVA---TVPSWLKK 417
VRLPTHGRVYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVA ++P W+
Sbjct: 361 VRLPTHGRVYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVANGSSLPEWVTD 420
Query: 418 PQDSQLEEGKPGYLDCLTQATPKPTVVWYRNQMLISEDSRFEVFKNGTLRINSVEVYDGT 477
GTL V D
Sbjct: 421 --------------------------------------------NAGTLHFARVTRDDAG 436
Query: 478 WYRCMSST-PAGSIEAQARVQVLEKLKFTPPPQPQQCMEFDKEATVPCSATGREKPTIKW 536
Y C++S P G I A ++ V + F P+ + A + C A G KP I+W
Sbjct: 437 NYTCIASNGPQGQIRAHVQLTVAVFITFKVEPERTTVYQ-GHTALLQCEAQGDPKPLIQW 495
Query: 537 ERADGSSLPEWVTDNA-----GTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVAVF 591
+ D P + G+L V +D+G YTCIA N
Sbjct: 496 KGKDRILDPTKLGPRMHIFQNGSLVIHDVAPEDSGRYTCIAGNS---------------- 539
Query: 592 ITFKVEPERTTVYQGHTALLQCEAQGDPKPLIQWKDKPVPEESEGPGSPPPYKMIQTIGL 651
C + PL DKPVPEESEGPGSPPPYKMIQTIGL
Sbjct: 540 ---------------------CNIKHTEAPLYV-VDKPVPEESEGPGSPPPYKMIQTIGL 577
Query: 652 SVGAAVAYIIAVLGLMFYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQNGQPSAEIQEEV 711
SVGAAVAYIIAVLGLMFYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQNGQPSAEIQEEV
Sbjct: 578 SVGAAVAYIIAVLGLMFYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQNGQPSAEIQEEV 637
Query: 712 ALTSLGSGPAATNKRHSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLV 771
ALTSLGSGPAATNKRHSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLV
Sbjct: 638 ALTSLGSGPAATNKRHSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLV 697
Query: 772 LVKSLQSKDEQQQLDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFL 831
LVKSLQSKDEQQQLDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFL
Sbjct: 698 LVKSLQSKDEQQQLDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFL 757
Query: 832 RISKSKDEKLKSQPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVS 891
RISKSKDEKLKSQPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVS
Sbjct: 758 RISKSKDEKLKSQPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVS 817
Query: 892 ALGLSKDVYNSEYYHFRQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPH 951
ALGLSKDVYNSEYYHFRQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPH
Sbjct: 818 ALGLSKDVYNSEYYHFRQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPH 877
Query: 952 GGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASALGDSTVD 1011
GGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASALGDSTVD
Sbjct: 878 GGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASALGDSTVD 937
Query: 1012 SKP 1014
SKP
Sbjct: 938 SKP 940
>gi|5031927 skeletal muscle receptor tyrosine kinase [Homo sapiens]
Length = 869
Score = 217 bits (553), Expect = 4e-56
Identities = 131/402 (32%), Positives = 214/402 (53%), Gaps = 39/402 (9%)
Query: 620 KPLIQWKDKPVPEESEGPGSPPPYKMIQTIGLSVGAAVAYIIAVLGLMFYCKKRCKAKRL 679
KP + + P S SP Y M T+ +S+ ++ A + + YC C+ ++
Sbjct: 470 KPSVDIPNLPSSSSSSFSVSPT-YSM--TVIISIMSSFAIFVLLTITTLYC---CRRRKQ 523
Query: 680 QKQPEGEEPEMECLNGGPLQNGQPSAEIQEEVALTSLGSGPAATNKRHSTSDKM---HFP 736
K + E + + E+ L L P + K+ +P
Sbjct: 524 WKNKKRESAAVTLTT------------LPSELLLDRLHPNPMYQRMPLLLNPKLLSLEYP 571
Query: 737 RSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSK-DEQQQLDFRRELEMFG 795
R++++ + +G+ FG VF A+A GL T+V VK L+ + Q DF+RE +
Sbjct: 572 RNNIEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAALMA 631
Query: 796 KLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKS--------KDEKLKSQ--- 844
+ ++ N+V+LLG+C +P ++ EY+ GDL +FLR D +++Q
Sbjct: 632 EFDNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSMRAQVSS 691
Query: 845 ----PLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVY 900
PLS +++ + QVA GM +LS +FVH+DLA RNCLV VK++ GLS+++Y
Sbjct: 692 PGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNIY 751
Query: 901 NSEYYHFRQ-AWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEV 959
+++YY + +P+RWM PE+I ++T+SDVWA+GV++WE+F++G P+ G A +EV
Sbjct: 752 SADYYKANENDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQPYYGMAHEEV 811
Query: 960 LADLQAGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEI 1001
+ ++ G L PE CP +LY LM+ CW+ P DRPSF+ I
Sbjct: 812 IYYVRDGNI-LSCPENCPVELYNLMRLCWSKLPADRPSFTSI 852
Score = 97.4 bits (241), Expect = 6e-20
Identities = 69/199 (34%), Positives = 98/199 (49%), Gaps = 8/199 (4%)
Query: 433 CLTQATPKPTVVWYRNQMLISE-DSRFEVFKNGTL-RINSVEVYDGTWYRCMSSTPAG-S 489
C ++ P+P + W RN++LI D+R+ + +NG L I SVE D Y C ++ G +
Sbjct: 49 CAVESYPQPEISWTRNKILIKLFDTRYSIRENGQLLTILSVEDSDDGIYCCTANNGVGGA 108
Query: 490 IEAQARVQVLEKLKFTPPPQPQQCMEFDKEATVPCSATGREKPTIKWERADGSSLPE--- 546
+E+ +QV K K T PP + +E K A +PC+ G KP++ W + D S L E
Sbjct: 109 VESCGALQVKMKPKITRPPINVKIIEGLK-AVLPCTTMGNPKPSVSWIKGD-SPLRENSR 166
Query: 547 WVTDNAGTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVAVFITFKVEPERTTVYQG 606
+G+L V ++DAG Y C+A N V+L V VF PE V G
Sbjct: 167 IAVLESGSLRIHNVQKEDAGQYRCVAKNSLGTAYSKVVKLEVEVFARILRAPESHNVTFG 226
Query: 607 HTALLQCEAQGDPKPLIQW 625
L C A G P P I W
Sbjct: 227 SFVTLHCTATGIPVPTITW 245
Score = 94.4 bits (233), Expect = 5e-19
Identities = 65/236 (27%), Positives = 107/236 (45%), Gaps = 15/236 (6%)
Query: 350 PEPSVWWEHAGVRLP---THGRVYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDVN- 405
P+P + W + + T + + G L + ++ +SD G+Y C A N G +
Sbjct: 55 PQPEISWTRNKILIKLFDTRYSIRENGQLLTILSVEDSDDGIYCCTANNGVGGAVESCGA 114
Query: 406 ITVATVPSWLKKPQDSQLEEGKPGYLDCLTQATPKPTVVWYRNQMLISEDSRFEVFKNGT 465
+ V P + P + ++ EG L C T PKP+V W + + E+SR V ++G+
Sbjct: 115 LQVKMKPKITRPPINVKIIEGLKAVLPCTTMGNPKPSVSWIKGDSPLRENSRIAVLESGS 174
Query: 466 LRINSVEVYDGTWYRCMSSTPAGSIEAQA---RVQVLEKLKFTPPPQPQQCMEFDKEATV 522
LRI++V+ D YRC++ G+ ++ V+V ++ P + F T+
Sbjct: 175 LRIHNVQKEDAGQYRCVAKNSLGTAYSKVVKLEVEVFARILRAP---ESHNVTFGSFVTL 231
Query: 523 PCSATGREKPTIKW----ERADGSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASN 574
C+ATG PTI W S+ E V D ++ G YTCIA+N
Sbjct: 232 HCTATGIPVPTITWIENGNAVSSGSIQESVKDRVIDSRL-QLFITKPGLYTCIATN 286
Score = 77.8 bits (190), Expect = 5e-14
Identities = 65/300 (21%), Positives = 125/300 (41%), Gaps = 21/300 (7%)
Query: 130 VLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSSKERNLTLRP 189
V+ P + + T C ++ +P+P W R+ + + +++ + LT+
Sbjct: 29 VITTPLETVDALVEEVATFMCAVESYPQPEISWTRNKILIKLFDTRYSIRENGQLLTILS 88
Query: 190 AGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVLAPQDVVVARYEEAMFHCQFS 249
G+Y C A++ G A S ++ + ++ P +V + +A+ C
Sbjct: 89 VEDSDDGIYCCTANNGVGGAVESCG---ALQVKMKPKITRPPINVKIIEGLKAVLPCTTM 145
Query: 250 AQPPPSLQWLFEDETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYRCIGQGQRGP 309
P PS+ W+ + ++P+ S R V +GSL + V+ +AG YRC+ + G
Sbjct: 146 GNPKPSVSWI-KGDSPLRENS------RIAVLESGSLRIHNVQKEDAGQYRCVAKNSLGT 198
Query: 310 PIILEATLHL---AEIEDMPLFEPRVFTAGSEERVTCLPPKGLPEPSVWWEHAGVRLPTH 366
L + A I P E T GS + C G+P P++ W G +
Sbjct: 199 AYSKVVKLEVEVFARILRAP--ESHNVTFGSFVTLHC-TATGIPVPTITWIENG-NAVSS 254
Query: 367 GRVYQKGHELVLANIAE---SDAGVYTCHAANLAGQRRQDVNITVA-TVPSWLKKPQDSQ 422
G + + + V+ + + + G+YTC A N G++ ++ W K +D++
Sbjct: 255 GSIQESVKDRVIDSRLQLFITKPGLYTCIATNKHGEKFSTAKAAATISIAEWSKPQKDNK 314
Score = 57.4 bits (137), Expect = 7e-08
Identities = 49/193 (25%), Positives = 87/193 (45%), Gaps = 15/193 (7%)
Query: 36 KQPSSQDALQGRRALLRCEVEAPGPVHVYWLLDGAPVQDTER-RFAQGSSLSFAAVDRLQ 94
+ P + ++G +A+L C V W+ +P+++ R + SL V + +
Sbjct: 125 RPPINVKIIEGLKAVLPCTTMGNPKPSVSWIKGDSPLRENSRIAVLESGSLRIHNVQK-E 183
Query: 95 DSGTFQCVARDDVTGEEARSANASFNIKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDG 154
D+G ++CVA++ + ++ +E +L+ P S + + VTL C G
Sbjct: 184 DAGQYRCVAKNSLGTAYSKVVKLE-----VEVFARILRAPESH-NVTFGSFVTLHCTATG 237
Query: 155 HPRPTYQWFRDGTPLSDGQSNHTVSSK--ERNLTLRPAGPEHSGLYSCCAHSAFGQACSS 212
P PT W +G +S G +V + + L L P GLY+C A + G+ S+
Sbjct: 238 IPVPTITWIENGNAVSSGSIQESVKDRVIDSRLQLFITKP---GLYTCIATNKHGEKFST 294
Query: 213 QN--FTLSIADES 223
T+SIA+ S
Sbjct: 295 AKAAATISIAEWS 307
>gi|59889558 neurotrophic tyrosine kinase, receptor, type 1 isoform 1
[Homo sapiens]
Length = 790
Score = 215 bits (548), Expect = 1e-55
Identities = 168/548 (30%), Positives = 260/548 (47%), Gaps = 60/548 (10%)
Query: 481 CMSSTPAGSIEAQARVQVLEKLKFTPPPQPQQCMEFDKEATVPCSATGREKPTIKWERAD 540
C + G E +V V F Q +E +P S G+ P+++W +
Sbjct: 265 CWAENDVGRAEVSVQVNV----SFPASVQLHTAVEMHHWC-IPFSVDGQPAPSLRW-LFN 318
Query: 541 GSSLPEWV-------------TDNAGTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLT 587
GS L E T G L + T + GNYT +A+N P GQ A +
Sbjct: 319 GSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAAN-PFGQASASI--- 374
Query: 588 VAVFIT--FKVEPERTTVYQGHTALLQCEAQGDPKPLIQWKDKPVPEESEGPGSPPPYKM 645
+A F+ F+ PE T+ GDP ++ KD+ P+ +
Sbjct: 375 MAAFMDNPFEFNPEDPIPDTNSTS-------GDP---VEKKDET------------PFGV 412
Query: 646 IQTIGLSVGAAVAYIIAVLGLMFYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQNGQPSA 705
+GL+V A + ++ +L ++ C +R K +P PE S+
Sbjct: 413 SVAVGLAVFACL-FLSTLLLVLNKCGRRNKFGI--NRPAVLAPEDGLAMSLHFMTLGGSS 469
Query: 706 EIQEEVALTSLGSGPAATNKRHSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEG 765
E + L + S + H R + LG+ FG+VFLA+ L
Sbjct: 470 LSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPE 529
Query: 766 VAETLVLVKSLQSKDEQQQLDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLG 825
+ LV VK+L+ E + DF+RE E+ L H ++VR G+C E P MV EY+ G
Sbjct: 530 QDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHG 589
Query: 826 DLKQFLRISKSKDEKLKS-------QPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAAR 878
DL +FLR S D KL + PL Q +A+ +QVA GM +L+ FVH+DLA R
Sbjct: 590 DLNRFLR-SHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATR 648
Query: 879 NCLVSAQRQVKVSALGLSKDVYNSEYYHF-RQAWVPLRWMSPEAILEGDFSTKSDVWAFG 937
NCLV VK+ G+S+D+Y+++YY + +P+RWM PE+IL F+T+SDVW+FG
Sbjct: 649 NCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFG 708
Query: 938 VLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCWALSPKDRPS 997
V++WE+FT+G+ P ++ E + + G+ L +P CP ++Y +M+ CW P+ R S
Sbjct: 709 VVLWEIFTYGKQPWYQLSNTEAIDCITQGR-ELERPRACPPEVYAIMRGCWQREPQQRHS 767
Query: 998 FSEIASAL 1005
++ + L
Sbjct: 768 IKDVHARL 775
Score = 40.0 bits (92), Expect = 0.011
Identities = 49/183 (26%), Positives = 70/183 (38%), Gaps = 33/183 (18%)
Query: 46 GRRALLRCEVEAPGPVHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSG--TFQCVA 103
G LLRC+VE G W+L T + SL + D C A
Sbjct: 208 GDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWA 267
Query: 104 RDDV-TGEEARSANASFNIKWIEAGPVVLKHPASEAEIQPQTQVTLR-----CHIDGHPR 157
+DV E + N SF PAS +Q T V + +DG P
Sbjct: 268 ENDVGRAEVSVQVNVSF--------------PAS---VQLHTAVEMHHWCIPFSVDGQPA 310
Query: 158 PTYQWFRDGTPLSDGQSNHT------VSSKERNLTLRPAGPEH--SGLYSCCAHSAFGQA 209
P+ +W +G+ L++ T + R+ LR P H +G Y+ A + FGQA
Sbjct: 311 PSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQA 370
Query: 210 CSS 212
+S
Sbjct: 371 SAS 373
>gi|56118210 neurotrophic tyrosine kinase, receptor, type 1 isoform 3
[Homo sapiens]
Length = 760
Score = 215 bits (548), Expect = 1e-55
Identities = 168/548 (30%), Positives = 260/548 (47%), Gaps = 60/548 (10%)
Query: 481 CMSSTPAGSIEAQARVQVLEKLKFTPPPQPQQCMEFDKEATVPCSATGREKPTIKWERAD 540
C + G E +V V F Q +E +P S G+ P+++W +
Sbjct: 235 CWAENDVGRAEVSVQVNV----SFPASVQLHTAVEMHHWC-IPFSVDGQPAPSLRW-LFN 288
Query: 541 GSSLPEWV-------------TDNAGTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLT 587
GS L E T G L + T + GNYT +A+N P GQ A +
Sbjct: 289 GSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAAN-PFGQASASI--- 344
Query: 588 VAVFIT--FKVEPERTTVYQGHTALLQCEAQGDPKPLIQWKDKPVPEESEGPGSPPPYKM 645
+A F+ F+ PE T+ GDP ++ KD+ P+ +
Sbjct: 345 MAAFMDNPFEFNPEDPIPDTNSTS-------GDP---VEKKDET------------PFGV 382
Query: 646 IQTIGLSVGAAVAYIIAVLGLMFYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQNGQPSA 705
+GL+V A + ++ +L ++ C +R K +P PE S+
Sbjct: 383 SVAVGLAVFACL-FLSTLLLVLNKCGRRNKFGI--NRPAVLAPEDGLAMSLHFMTLGGSS 439
Query: 706 EIQEEVALTSLGSGPAATNKRHSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEG 765
E + L + S + H R + LG+ FG+VFLA+ L
Sbjct: 440 LSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPE 499
Query: 766 VAETLVLVKSLQSKDEQQQLDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLG 825
+ LV VK+L+ E + DF+RE E+ L H ++VR G+C E P MV EY+ G
Sbjct: 500 QDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHG 559
Query: 826 DLKQFLRISKSKDEKLKS-------QPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAAR 878
DL +FLR S D KL + PL Q +A+ +QVA GM +L+ FVH+DLA R
Sbjct: 560 DLNRFLR-SHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATR 618
Query: 879 NCLVSAQRQVKVSALGLSKDVYNSEYYHF-RQAWVPLRWMSPEAILEGDFSTKSDVWAFG 937
NCLV VK+ G+S+D+Y+++YY + +P+RWM PE+IL F+T+SDVW+FG
Sbjct: 619 NCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFG 678
Query: 938 VLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCWALSPKDRPS 997
V++WE+FT+G+ P ++ E + + G+ L +P CP ++Y +M+ CW P+ R S
Sbjct: 679 VVLWEIFTYGKQPWYQLSNTEAIDCITQGR-ELERPRACPPEVYAIMRGCWQREPQQRHS 737
Query: 998 FSEIASAL 1005
++ + L
Sbjct: 738 IKDVHARL 745
Score = 40.0 bits (92), Expect = 0.011
Identities = 49/183 (26%), Positives = 70/183 (38%), Gaps = 33/183 (18%)
Query: 46 GRRALLRCEVEAPGPVHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSG--TFQCVA 103
G LLRC+VE G W+L T + SL + D C A
Sbjct: 178 GDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWA 237
Query: 104 RDDV-TGEEARSANASFNIKWIEAGPVVLKHPASEAEIQPQTQVTLR-----CHIDGHPR 157
+DV E + N SF PAS +Q T V + +DG P
Sbjct: 238 ENDVGRAEVSVQVNVSF--------------PAS---VQLHTAVEMHHWCIPFSVDGQPA 280
Query: 158 PTYQWFRDGTPLSDGQSNHT------VSSKERNLTLRPAGPEH--SGLYSCCAHSAFGQA 209
P+ +W +G+ L++ T + R+ LR P H +G Y+ A + FGQA
Sbjct: 281 PSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQA 340
Query: 210 CSS 212
+S
Sbjct: 341 SAS 343
>gi|4585712 neurotrophic tyrosine kinase, receptor, type 1 isoform 2
[Homo sapiens]
Length = 796
Score = 215 bits (547), Expect = 2e-55
Identities = 167/548 (30%), Positives = 261/548 (47%), Gaps = 54/548 (9%)
Query: 481 CMSSTPAGSIEAQARVQVLEKLKFTPPPQPQQCMEFDKEATVPCSATGREKPTIKWERAD 540
C + G E +V V F Q +E +P S G+ P+++W +
Sbjct: 265 CWAENDVGRAEVSVQVNV----SFPASVQLHTAVEMHHWC-IPFSVDGQPAPSLRW-LFN 318
Query: 541 GSSLPEWV-------------TDNAGTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLT 587
GS L E T G L + T + GNYT +A+N P GQ A +
Sbjct: 319 GSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAAN-PFGQASASI--- 374
Query: 588 VAVFIT--FKVEPERTTVYQGHTALLQCEAQGDPKPLIQWKDKPVPEESEGPGSPPPYKM 645
+A F+ F+ PE + + + GDP ++ KD+ P+ +
Sbjct: 375 MAAFMDNPFEFNPE-DPIPVSFSPVDTNSTSGDP---VEKKDET------------PFGV 418
Query: 646 IQTIGLSVGAAVAYIIAVLGLMFYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQNGQPSA 705
+GL+V A + ++ +L ++ C +R K +P PE S+
Sbjct: 419 SVAVGLAVFACL-FLSTLLLVLNKCGRRNKFGI--NRPAVLAPEDGLAMSLHFMTLGGSS 475
Query: 706 EIQEEVALTSLGSGPAATNKRHSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEG 765
E + L + S + H R + LG+ FG+VFLA+ L
Sbjct: 476 LSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPE 535
Query: 766 VAETLVLVKSLQSKDEQQQLDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLG 825
+ LV VK+L+ E + DF+RE E+ L H ++VR G+C E P MV EY+ G
Sbjct: 536 QDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHG 595
Query: 826 DLKQFLRISKSKDEKLKS-------QPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAAR 878
DL +FLR S D KL + PL Q +A+ +QVA GM +L+ FVH+DLA R
Sbjct: 596 DLNRFLR-SHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATR 654
Query: 879 NCLVSAQRQVKVSALGLSKDVYNSEYYHF-RQAWVPLRWMSPEAILEGDFSTKSDVWAFG 937
NCLV VK+ G+S+D+Y+++YY + +P+RWM PE+IL F+T+SDVW+FG
Sbjct: 655 NCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFG 714
Query: 938 VLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCWALSPKDRPS 997
V++WE+FT+G+ P ++ E + + G+ L +P CP ++Y +M+ CW P+ R S
Sbjct: 715 VVLWEIFTYGKQPWYQLSNTEAIDCITQGR-ELERPRACPPEVYAIMRGCWQREPQQRHS 773
Query: 998 FSEIASAL 1005
++ + L
Sbjct: 774 IKDVHARL 781
Score = 40.0 bits (92), Expect = 0.011
Identities = 49/183 (26%), Positives = 70/183 (38%), Gaps = 33/183 (18%)
Query: 46 GRRALLRCEVEAPGPVHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSG--TFQCVA 103
G LLRC+VE G W+L T + SL + D C A
Sbjct: 208 GDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWA 267
Query: 104 RDDV-TGEEARSANASFNIKWIEAGPVVLKHPASEAEIQPQTQVTLR-----CHIDGHPR 157
+DV E + N SF PAS +Q T V + +DG P
Sbjct: 268 ENDVGRAEVSVQVNVSF--------------PAS---VQLHTAVEMHHWCIPFSVDGQPA 310
Query: 158 PTYQWFRDGTPLSDGQSNHT------VSSKERNLTLRPAGPEH--SGLYSCCAHSAFGQA 209
P+ +W +G+ L++ T + R+ LR P H +G Y+ A + FGQA
Sbjct: 311 PSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQA 370
Query: 210 CSS 212
+S
Sbjct: 371 SAS 373
Score = 30.8 bits (68), Expect = 6.7
Identities = 36/162 (22%), Positives = 61/162 (37%), Gaps = 23/162 (14%)
Query: 376 LVLANI-AESDAGVYTCHAANLAGQRRQDVNITVATVPSWLKKPQDSQLEEGKPGYLDCL 434
L LAN+ ++ + TC A N G+ V + V+ P QL + C+
Sbjct: 249 LTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSF-------PASVQLHTAVEMHHWCI 301
Query: 435 ---TQATPKPTVVWYRNQMLISEDSRF----------EVFKNGTLRINSVEVYDGTWYRC 481
P P++ W N +++E S E ++G LR+N + Y
Sbjct: 302 PFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTL 361
Query: 482 MSSTPAGSIEAQARVQVLEK-LKFTP-PPQPQQCMEFDKEAT 521
+++ P G A ++ +F P P P D +T
Sbjct: 362 LAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNST 403
>gi|4503711 fibroblast growth factor receptor 3 isoform 1 precursor
[Homo sapiens]
Length = 806
Score = 214 bits (546), Expect = 3e-55
Identities = 196/753 (26%), Positives = 306/753 (40%), Gaps = 127/753 (16%)
Query: 329 EPRVFTAGSEERVTCLPPKGLPEPSVWWEHAGVRLPTHGRVYQKGHELVLANIAESDAGV 388
E VF +G ++C PP G P W G L RV L + N + D+G
Sbjct: 47 EQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDSGA 106
Query: 389 YTCHAANLAGQRRQDVNITVATVPS------WLKKPQDSQLEEGKPGY------------ 430
Y+C L + ++ V PS + +D+ ++ G P +
Sbjct: 107 YSCRQ-RLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLA 165
Query: 431 --------LDCLTQATPKPTVVWYRNQMLISEDSRFEVFK----NGTLRINSVEVYDGTW 478
C P P++ W +N + R K +L + SV D
Sbjct: 166 VPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGN 225
Query: 479 YRCMSSTPAGSIEAQARVQVLEKLKFTPPPQP----QQCMEFDKEATVPCSATGREKPTI 534
Y C+ GSI + VLE+ P Q Q + C +P I
Sbjct: 226 YTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHI 285
Query: 535 KWER---ADGSSL-PEWV-------TDNAGT-------LHFARVTRDDAGNYTCIASNGP 576
+W + +GS + P+ T A T L VT +DAG YTC+A N
Sbjct: 286 QWLKHVEVNGSKVGPDGTPYVTVLKTAGANTTDKELEVLSLHNVTFEDAGEYTCLAGNS- 344
Query: 577 QGQIRAHVQLTVAVFITFKVEPERTTVYQGHTALLQCEAQGDPKPLIQWKDKPVPEESEG 636
I F V L++ + G I
Sbjct: 345 ---------------IGFSHHSAWLVVLPAEEELVEADEAGSVYAGI------------- 376
Query: 637 PGSPPPYKMIQTIGLSVGAAVAYIIAVLGLMFYCKKRCKAKR---------LQKQPEGEE 687
LS G I V+ + C+ R K+ + + P +
Sbjct: 377 --------------LSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSPTVHKISRFPLKRQ 422
Query: 688 PEMECLNGGPLQNGQPSAEIQEEVALTSLGSGPAATNKRH---STSDKMHFPRSSLQPIT 744
+E + + + P I A S G GP N K R+ L
Sbjct: 423 VSLE--SNASMSSNTPLVRI----ARLSSGEGPTLANVSELELPADPKWELSRARLTLGK 476
Query: 745 TLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQLDFR---RELEMFGKLN-HA 800
LG+ FG+V +A+A G+++ A V V KD+ D E+EM + H
Sbjct: 477 PLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHK 536
Query: 801 NVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISK------SKDE-KLKSQPLSTKQKVA 853
N++ LLG C + P Y+++EY G+L++FLR + S D K + L+ K V+
Sbjct: 537 NIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVS 596
Query: 854 LCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEYY-HFRQAWV 912
QVA GME+L++ + +H+DLAARN LV+ +K++ GL++DV+N +YY +
Sbjct: 597 CAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRL 656
Query: 913 PLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQ 972
P++WM+PEA+ + ++ +SDVW+FGVL+WE+FT G P+ G +E+ L+ G R+ +
Sbjct: 657 PVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGH-RMDK 715
Query: 973 PEGCPSKLYRLMQRCWALSPKDRPSFSEIASAL 1005
P C LY +M+ CW +P RP+F ++ L
Sbjct: 716 PANCTHDLYMIMRECWHAAPSQRPTFKQLVEDL 748
Score = 53.5 bits (127), Expect = 1e-06
Identities = 55/259 (21%), Positives = 90/259 (34%), Gaps = 48/259 (18%)
Query: 37 QPSSQDAL---QGRRALLRCEVEAPGPVH-VYWLLDGAPVQDTERRFAQGSSLSFAAVDR 92
+P Q+ L G L C GP+ W+ DG + +ER L
Sbjct: 42 EPGQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASH 101
Query: 93 LQDSGTFQCVAR--------------------DDVTGEEARSANASFNIKWIEAGPVVLK 132
+DSG + C R DD GE+ ++ G
Sbjct: 102 -EDSGAYSCRQRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTG------VDTGAPYWT 154
Query: 133 HPASEAE----IQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSS-----KER 183
P + + V RC G+P P+ W ++G + + H + ++
Sbjct: 155 RPERMDKKLLAVPAANTVRFRCPAAGNPTPSISWLKNG---REFRGEHRIGGIKLRHQQW 211
Query: 184 NLTLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVL---APQDVVVARYE 240
+L + P G Y+C + FG Q +TL + + S R +L P +
Sbjct: 212 SLVMESVVPSDRGNYTCVVENKFGSI--RQTYTLDVLERSPHRPILQAGLPANQTAVLGS 269
Query: 241 EAMFHCQFSAQPPPSLQWL 259
+ FHC+ + P +QWL
Sbjct: 270 DVEFHCKVYSDAQPHIQWL 288
Score = 34.7 bits (78), Expect = 0.47
Identities = 66/294 (22%), Positives = 97/294 (32%), Gaps = 62/294 (21%)
Query: 154 GHPRPTYQWFRDGTPLSDGQSNHTVSSKERNLTLRPAGPEHSGLYSCCAHSAFGQACSSQ 213
G P W +DGT L + V + L + A E SG YSC C
Sbjct: 66 GGPMGPTVWVKDGTGLVPSER---VLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLC--- 119
Query: 214 NFTLSIAD-------------------ESFARVVLAPQDV-----VVARYEEAMFHCQFS 249
+F++ + D ++ A P+ + V F C +
Sbjct: 120 HFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAA 179
Query: 250 AQPPPSLQWLFED-ETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYRCIGQGQRG 308
P PS+ WL E +R LR SL++ V P + G Y C+ + + G
Sbjct: 180 GNPTPSISWLKNGREFRGEHRIGGIKLRHQ----QWSLVMESVVPSDRGNYTCVVENKFG 235
Query: 309 PPIILEATLHLAEIEDMP--------LFEPRVFTAGSEERVTCLPPKGLPEPSVWWEHA- 359
+ T L +E P L + GS+ C W +H
Sbjct: 236 S---IRQTYTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVE 292
Query: 360 --GVRLPTHGRVY-------------QKGHELVLANIAESDAGVYTCHAANLAG 398
G ++ G Y ++ L L N+ DAG YTC A N G
Sbjct: 293 VNGSKVGPDGTPYVTVLKTAGANTTDKELEVLSLHNVTFEDAGEYTCLAGNSIG 346
>gi|65506745 neurotrophic tyrosine kinase, receptor, type 2 isoform c
precursor [Homo sapiens]
Length = 822
Score = 210 bits (535), Expect = 5e-54
Identities = 174/616 (28%), Positives = 275/616 (44%), Gaps = 49/616 (7%)
Query: 423 LEEGKPGYLDCLTQATPKPTVVWYRNQMLISEDSRFEVFKNGTLRINSVEVYD-GTWYRC 481
+EEGK L C P P + W L+S+ G+LRI ++ D G C
Sbjct: 208 VEEGKSITLSCSVAGDPVPNMYWDVGN-LVSKHMNETSHTQGSLRITNISSDDSGKQISC 266
Query: 482 MSSTPAGSIEAQARVQVLEKLKFTPPPQPQQCMEFDKEATVPCSATGREKPTIKWERADG 541
++ G + + V F P + D +P + G KP ++W +G
Sbjct: 267 VAENLVGEDQDSVNLTV----HFAPTITFLESPTSDHHWCIPFTVKGNPKPALQWFY-NG 321
Query: 542 SSLPEWV-----------TDNAGTLHFARVTRDDAGNYTCIASNG---PQGQIRAHVQLT 587
+ L E T+ G L T + G+YT IA N + QI AH
Sbjct: 322 AILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGW 381
Query: 588 VAVFITFKVEPERTTV-YQGHTALLQCEAQGDPKPLIQWKDKPVPEESEGPGSPPPYKMI 646
I P V Y+ + GD + G Y ++
Sbjct: 382 PG--IDDGANPNYPDVIYEDYGTA--ANDIGDTTNRSNEIPSTDVTDKTGREHLSVYAVV 437
Query: 647 QTIGLSVGAAVAYIIAVLGLMFYCKKRCK--AKRLQKQPEGEEPEMECLNGGPLQNGQPS 704
I VG + ++ +L L + K K A + + P NG N S
Sbjct: 438 -VIASVVGFCLLVMLFLLKLARHSKFGMKGPASVISNDDDSASPLHHISNGS---NTPSS 493
Query: 705 AEIQEEVALTSLGSGPAATNKRHS--TSDKM-------HFPRSSLQPITTLGKSEFGEVF 755
+E + + + P N ++ T+ ++ H R ++ LG+ FG+VF
Sbjct: 494 SEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDTFVQHIKRHNIVLKRELGEGAFGKVF 553
Query: 756 LAKAQGLEEGVAETLVLVKSLQSKDEQQQLDFRRELEMFGKLNHANVVRLLGLCREAEPH 815
LA+ L + LV VK+L+ + + DF RE E+ L H ++V+ G+C E +P
Sbjct: 554 LAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPL 613
Query: 816 YMVLEYVDLGDLKQFLRISKSKDEKLKSQ-----PLSTKQKVALCTQVALGMEHLSNNRF 870
MV EY+ GDL +FLR + D L ++ L+ Q + + Q+A GM +L++ F
Sbjct: 614 IMVFEYMKHGDLNKFLR-AHGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHF 672
Query: 871 VHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEYYHF-RQAWVPLRWMSPEAILEGDFST 929
VH+DLA RNCLV VK+ G+S+DVY+++YY +P+RWM PE+I+ F+T
Sbjct: 673 VHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTT 732
Query: 930 KSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCWA 989
+SDVW+ GV++WE+FT+G+ P +++EV+ + G+ L +P CP ++Y LM CW
Sbjct: 733 ESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRV-LQRPRTCPQEVYELMLGCWQ 791
Query: 990 LSPKDRPSFSEIASAL 1005
P R + I + L
Sbjct: 792 REPHMRKNIKGIHTLL 807
Score = 44.3 bits (103), Expect = 6e-04
Identities = 35/120 (29%), Positives = 53/120 (44%), Gaps = 10/120 (8%)
Query: 510 PQQCMEFDKEATVPCSATGREKPTIKWERAD-GSSLPEWVTDNAGTLHFARVTRDDAG-N 567
P +E K T+ CS G P + W+ + S + G+L ++ DD+G
Sbjct: 204 PNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQ 263
Query: 568 YTCIASNGPQGQIRAHVQLTV--AVFITFKVEPERTTVYQGHTALLQCEAQGDPKPLIQW 625
+C+A N G+ + V LTV A ITF P H + +G+PKP +QW
Sbjct: 264 ISCVAEN-LVGEDQDSVNLTVHFAPTITFLESPT-----SDHHWCIPFTVKGNPKPALQW 317
Score = 37.4 bits (85), Expect = 0.072
Identities = 36/172 (20%), Positives = 68/172 (39%), Gaps = 20/172 (11%)
Query: 45 QGRRALLRCEVEAPGPVHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSGTFQCVAR 104
+G+ L C V ++YW + + SL + CVA
Sbjct: 210 EGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVA- 268
Query: 105 DDVTGEEARSANASFNIKWIEAGPVV--LKHPASEAEIQPQTQVTLRCHIDGHPRPTYQW 162
+++ GE+ S N + + P + L+ P S+ + + G+P+P QW
Sbjct: 269 ENLVGEDQDSVNLT-----VHFAPTITFLESPTSDHHW------CIPFTVKGNPKPALQW 317
Query: 163 FRDGTPLSDGQ----SNHTVSSKERNLTLRPAGPEH--SGLYSCCAHSAFGQ 208
F +G L++ + H + E + L+ P H +G Y+ A + +G+
Sbjct: 318 FYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGK 369
Score = 33.5 bits (75), Expect = 1.0
Identities = 44/179 (24%), Positives = 66/179 (36%), Gaps = 18/179 (10%)
Query: 135 ASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSSKERNLTLRPAGPEH 194
A ++ +TL C + G P P W D L N T S + +L + +
Sbjct: 203 APNLTVEEGKSITLSCSVAGDPVPNMYW--DVGNLVSKHMNET-SHTQGSLRITNISSDD 259
Query: 195 SG-LYSCCAHSAFGQACSSQNFTLSIADESFARVVLAPQDVVVARYEEAMFHCQFSAQPP 253
SG SC A + G+ S N T+ FA + + + F P
Sbjct: 260 SGKQISCVAENLVGEDQDSVNLTV-----HFAPTITFLESPTSDHHWCIPF--TVKGNPK 312
Query: 254 PSLQWLFEDETPITNRSR----PPHLRRATVFANGSLLLTQVRPRNAGIYRCIGQGQRG 308
P+LQW + I N S+ H+ T + +G L L N G Y I + + G
Sbjct: 313 PALQWFYNG--AILNESKYICTKIHVTNHTEY-HGCLQLDNPTHMNNGDYTLIAKNEYG 368
>gi|29029632 anaplastic lymphoma kinase [Homo sapiens]
Length = 1620
Score = 210 bits (535), Expect = 5e-54
Identities = 124/381 (32%), Positives = 207/381 (54%), Gaps = 25/381 (6%)
Query: 639 SPPPYKMIQTIGLSVGAAV--AYIIAVLGLMFYCKKRCKAKRLQK-QPEGEEPEMECLNG 695
+P P+ + I V +A+ A ++A G+M ++ K + LQ Q E + PE +
Sbjct: 1026 TPEPHLPLSLILSVVTSALVAALVLAFSGIMIVYRR--KHQELQAMQMELQSPEYKL--- 1080
Query: 696 GPLQNGQPSAEIQEEVALTSLGSGPAATNKRHSTSDKMHFPRSSLQPITTLGKSEFGEVF 755
++++ +T K S SD PR ++ I LG FGEV+
Sbjct: 1081 ---------SKLRTSTIMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVY 1131
Query: 756 LAKAQGLEEGVAETLVLVKSLQSK-DEQQQLDFRRELEMFGKLNHANVVRLLGLCREAEP 814
+ G+ + V VK+L EQ +LDF E + K NH N+VR +G+ ++ P
Sbjct: 1132 EGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLP 1191
Query: 815 HYMVLEYVDLGDLKQFLRISKSKDEKLKSQPLSTKQKVALCTQVALGMEHLSNNRFVHKD 874
+++LE + GDLK FLR ++ + + S L+ + + +A G ++L N F+H+D
Sbjct: 1192 RFILLELMAGGDLKSFLRETRPRPSQPSS--LAMLDLLHVARDIACGCQYLEENHFIHRD 1249
Query: 875 LAARNCLVSAQ---RQVKVSALGLSKDVYNSEYYHFRQ-AWVPLRWMSPEAILEGDFSTK 930
+AARNCL++ R K+ G+++D+Y + YY A +P++WM PEA +EG F++K
Sbjct: 1250 IAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSK 1309
Query: 931 SDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCWAL 990
+D W+FGVL+WE+F+ G MP+ +++ EVL + +G R+ P+ CP +YR+M +CW
Sbjct: 1310 TDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSG-GRMDPPKNCPGPVYRIMTQCWQH 1368
Query: 991 SPKDRPSFSEIASALGDSTVD 1011
P+DRP+F+ I + T D
Sbjct: 1369 QPEDRPNFAIILERIEYCTQD 1389
>gi|221316639 fibroblast growth factor receptor 2 isoform 1 precursor
[Homo sapiens]
Length = 821
Score = 207 bits (528), Expect = 3e-53
Identities = 194/767 (25%), Positives = 315/767 (41%), Gaps = 145/767 (18%)
Query: 329 EPRVFTA--GSEERVTCLPPKGLPEPSVW-WEHAGVRLPTHGRVYQKGHELVLANIAESD 385
+P V+ A G V CL L + +V W GV L + R G L + D
Sbjct: 46 QPEVYVAAPGESLEVRCL----LKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRD 101
Query: 386 AGVYTCHAANLAGQRRQD--VNITVAT------------------------VPSWLKKPQ 419
+G+Y C A+ VN+T A P W +
Sbjct: 102 SGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEK 161
Query: 420 DSQLEEGKPGY----LDCLTQATPKPTVVWYRNQMLISEDSRFEVFK----NGTLRINSV 471
+ P C P PT+ W +N ++ R +K + +L + SV
Sbjct: 162 MEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESV 221
Query: 472 EVYDGTWYRCMSSTPAGSIEAQARVQVLEKLKFTP------PPQPQQCMEFDKEATVPCS 525
D Y C+ GSI + V+E+ P P + D E C
Sbjct: 222 VPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFV--CK 279
Query: 526 ATGREKPTIKWER---ADGSS-----LPEW-VTDNAGT---------LHFARVTRDDAGN 567
+P I+W + +GS LP V AG L+ VT +DAG
Sbjct: 280 VYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGE 339
Query: 568 YTCIASNGPQGQIRAHVQLTVAVFITFKVEPERTTVYQGHTALLQCEAQGDPKPLIQWKD 627
YTC+A N ++ I+F H+A L
Sbjct: 340 YTCLAGN--------------SIGISF------------HSAWLTV-------------- 359
Query: 628 KPVPEESEGPGSPPPYKMIQTIGLSVGAAVAYIIAVLGLMFYCKKRCKAKRLQKQPE-GE 686
P P + + P Y I + V ++ V+ C+ K K+P+
Sbjct: 360 LPAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVI--------LCRMKNTTKKPDFSS 411
Query: 687 EPEMECLNGGPLQNGQPSAEIQEEVALTSLGSGPAATNKRHSTSD--------------- 731
+P + L Q + + ++ S T + ST+D
Sbjct: 412 QPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPED 471
Query: 732 -KMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQLDFR-- 788
K FPR L LG+ FG+V +A+A G+++ + V V KD+ + D
Sbjct: 472 PKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDL 531
Query: 789 -RELEMFGKLN-HANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKD-------E 839
E+EM + H N++ LLG C + P Y+++EY G+L+++LR +
Sbjct: 532 VSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDIN 591
Query: 840 KLKSQPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDV 899
++ + ++ K V+ Q+A GME+L++ + +H+DLAARN LV+ +K++ GL++D+
Sbjct: 592 RVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDI 651
Query: 900 YNSEYYH-FRQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDE 958
N +YY +P++WM+PEA+ + ++ +SDVW+FGVLMWE+FT G P+ G +E
Sbjct: 652 NNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEE 711
Query: 959 VLADLQAGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASAL 1005
+ L+ G R+ +P C ++LY +M+ CW P RP+F ++ L
Sbjct: 712 LFKLLKEGH-RMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDL 757
Score = 47.0 bits (110), Expect = 9e-05
Identities = 53/257 (20%), Positives = 87/257 (33%), Gaps = 41/257 (15%)
Query: 35 IKQPSSQDALQGRRALLRCEVEAPGPVHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQ 94
I QP A G +RC ++ + W DG + R G L +
Sbjct: 44 ISQPEVYVAAPGESLEVRCLLKDAAVIS--WTKDGVHLGPNNRTVLIGEYLQIKGATP-R 100
Query: 95 DSGTFQCVA------------------------RDDVTGEEARSANASFNIK---WIEAG 127
DSG + C A DD G E + S N + W
Sbjct: 101 DSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTE 160
Query: 128 PVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQ--SNHTVSSKERNL 185
+ + A A V RC G+P PT +W ++G + V ++ +L
Sbjct: 161 KMEKRLHAVPAA----NTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSL 216
Query: 186 TLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVL---APQDVVVARYEEA 242
+ P G Y+C + +G + + L + + S R +L P + +
Sbjct: 217 IMESVVPSDKGNYTCVVENEYGSI--NHTYHLDVVERSPHRPILQAGLPANASTVVGGDV 274
Query: 243 MFHCQFSAQPPPSLQWL 259
F C+ + P +QW+
Sbjct: 275 EFVCKVYSDAQPHIQWI 291
Score = 43.5 bits (101), Expect = 0.001
Identities = 79/343 (23%), Positives = 118/343 (34%), Gaps = 82/343 (23%)
Query: 132 KHPASEAEIQ---PQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSSKERNLTLR 188
K+ S+ E+ P + +RC + W +DG L G +N TV E L ++
Sbjct: 41 KYQISQPEVYVAAPGESLEVRCLLKD--AAVISWTKDGVHL--GPNNRTVLIGEY-LQIK 95
Query: 189 PAGPEHSGLYSCCAHSAFGQACSSQNFTLSIAD--------------ESF----ARVVLA 230
A P SGLY+C A + F +++ D E F + A
Sbjct: 96 GATPRDSGLYACTASRTVDS--ETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRA 153
Query: 231 PQDVVVARYEEAM----------FHCQFSAQPPPSLQWL-----FEDETPITN-RSRPPH 274
P + E+ + F C P P+++WL F+ E I + R H
Sbjct: 154 PYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQH 213
Query: 275 LRRATVFANGSLLLTQVRPRNAGIYRCIGQGQRGPPIILEATLHLAEIEDMP-------- 326
SL++ V P + G Y C+ + + G + T HL +E P
Sbjct: 214 ---------WSLIMESVVPSDKGNYTCVVENEYGS---INHTYHLDVVERSPHRPILQAG 261
Query: 327 LFEPRVFTAGSEERVTCLPPKGLPEPSVWW----EHAGVRLPTHGRVYQKG--------- 373
L G + C +P + W E G + G Y K
Sbjct: 262 LPANASTVVGGDVEFVCKVYSD-AQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTT 320
Query: 374 ----HELVLANIAESDAGVYTCHAANLAGQRRQDVNITVATVP 412
L + N+ DAG YTC A N G +TV P
Sbjct: 321 DKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVLPAP 363
>gi|13186251 fibroblast growth factor receptor 1 isoform 2 precursor
[Homo sapiens]
Length = 820
Score = 207 bits (528), Expect = 3e-53
Identities = 182/735 (24%), Positives = 313/735 (42%), Gaps = 127/735 (17%)
Query: 353 SVWWEHAGVRLPTHGRVYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVA--- 409
S+ W GV+L R G E+ + + +D+G+Y C ++ +G ++ V+
Sbjct: 63 SINWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSDAL 122
Query: 410 --------------------------TVPSWLKKPQDSQLEEGKPGY----LDCLTQATP 439
P W + + P C + TP
Sbjct: 123 PSSEDDDDDDDSSSEEKETDNTKPNPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTP 182
Query: 440 KPTVVWYRNQMLISEDSRFEVFK----NGTLRINSVEVYDGTWYRCMSSTPAGSIEAQAR 495
PT+ W +N D R +K ++ ++SV D Y C+ GSI +
Sbjct: 183 NPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQ 242
Query: 496 VQVLEKLKFTPPPQP----QQCMEFDKEATVPCSATGREKPTIKWER---ADGSSL-PE- 546
+ V+E+ P Q + + C +P I+W + +GS + P+
Sbjct: 243 LDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDN 302
Query: 547 ----WVTDNAGT---------LHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVAVFIT 593
+ AG LH V+ +DAG YTC+A N +H + V
Sbjct: 303 LPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIG---LSHHSAWLTVLEA 359
Query: 594 FKVEPERTT--------VYQGHTALLQCEAQGDPKPLIQWKDKPVPEESEGPGSPPPYKM 645
+ P T +Y L+ C +I +K K ++S+ +K+
Sbjct: 360 LEERPAVMTSPLYLEIIIYCTGAFLISCMVGS----VIVYKMKSGTKKSDFHSQMAVHKL 415
Query: 646 IQTIGLSVGAAVAYIIAVL---GLMFYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQNGQ 702
++I L V+ + G++ R + +G P+ G
Sbjct: 416 AKSIPLRRQVTVSADSSASMNSGVLLVRPSRLSS-----------------SGTPMLAGV 458
Query: 703 PSAEIQEEVALTSLGSGPAATNKRHSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQGL 762
E+ E+ + PR L LG+ FG+V LA+A GL
Sbjct: 459 SEYELPED--------------------PRWELPRDRLVLGKPLGEGCFGQVVLAEAIGL 498
Query: 763 EEGVAE--TLVLVKSLQSKDEQQQL-DFRRELEMFGKLN-HANVVRLLGLCREAEPHYMV 818
++ T V VK L+S ++ L D E+EM + H N++ LLG C + P Y++
Sbjct: 499 DKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVI 558
Query: 819 LEYVDLGDLKQFLRISKSKDEKLKSQP-------LSTKQKVALCTQVALGMEHLSNNRFV 871
+EY G+L+++L+ + + P LS+K V+ QVA GME+L++ + +
Sbjct: 559 VEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCI 618
Query: 872 HKDLAARNCLVSAQRQVKVSALGLSKDVYNSEYY-HFRQAWVPLRWMSPEAILEGDFSTK 930
H+DLAARN LV+ +K++ GL++D+++ +YY +P++WM+PEA+ + ++ +
Sbjct: 619 HRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQ 678
Query: 931 SDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCWAL 990
SDVW+FGVL+WE+FT G P+ G +E+ L+ G R+ +P C ++LY +M+ CW
Sbjct: 679 SDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGH-RMDKPSNCTNELYMMMRDCWHA 737
Query: 991 SPKDRPSFSEIASAL 1005
P RP+F ++ L
Sbjct: 738 VPSQRPTFKQLVEDL 752
Score = 50.8 bits (120), Expect = 6e-06
Identities = 76/327 (23%), Positives = 121/327 (37%), Gaps = 73/327 (22%)
Query: 140 IQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSSKERNLTLRPAGPEHSGLYS 199
+ P + LRC + + + W RDG L++ SN T + E + ++ + P SGLY+
Sbjct: 45 VHPGDLLQLRCRLRDDVQ-SINWLRDGVQLAE--SNRTRITGEE-VEVQDSVPADSGLYA 100
Query: 200 CCAHSAFGQACSSQNFTLSIAD--------------------------ESFARVVLAPQD 233
C S G + F+++++D A +P+
Sbjct: 101 CVTSSPSGS--DTTYFSVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNPVAPYWTSPEK 158
Query: 234 V-----VVARYEEAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRA--TVFANGSL 286
+ V + F C S P P+L+WL + +P H +A S+
Sbjct: 159 MEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGK-----EFKPDHRIGGYKVRYATWSI 213
Query: 287 LLTQVRPRNAGIYRCIGQGQRGPPIILEATLHLAEIEDMP--------LFEPRVFTAGSE 338
++ V P + G Y CI + + G + T L +E P L + GS
Sbjct: 214 IMDSVVPSDKGNYTCIVENEYGS---INHTYQLDVVERSPHRPILQAGLPANKTVALGSN 270
Query: 339 ERVTCLPPKGLPEPSVWW-EHAGVR--------------LPTHG-RVYQKGHELV-LANI 381
C P+P + W +H V L T G K E++ L N+
Sbjct: 271 VEFMCKVYSD-PQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNV 329
Query: 382 AESDAGVYTCHAANLAGQRRQDVNITV 408
+ DAG YTC A N G +TV
Sbjct: 330 SFEDAGEYTCLAGNSIGLSHHSAWLTV 356
Score = 47.4 bits (111), Expect = 7e-05
Identities = 54/248 (21%), Positives = 87/248 (35%), Gaps = 49/248 (19%)
Query: 48 RALLRCEVEAPGPVHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQ-DSGTFQCVAR-- 104
R LR +V++ + WL DG + ++ R G + D + DSG + CV
Sbjct: 54 RCRLRDDVQS-----INWLRDGVQLAESNRTRITGEEVEVQ--DSVPADSGLYACVTSSP 106
Query: 105 -------------------------DDVTGEEARSANASFNIK---WIEAGPVVLKHPAS 136
DD + EE + N N W + K A
Sbjct: 107 SGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNPVAPYWTSPEKMEKKLHAV 166
Query: 137 EAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQ--SNHTVSSKERNLTLRPAGPEH 194
A V +C G P PT +W ++G + V ++ + P
Sbjct: 167 PAA----KTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSD 222
Query: 195 SGLYSCCAHSAFGQACSSQNFTLSIADESFARVVL---APQDVVVARYEEAMFHCQFSAQ 251
G Y+C + +G + + L + + S R +L P + VA F C+ +
Sbjct: 223 KGNYTCIVENEYGSI--NHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSD 280
Query: 252 PPPSLQWL 259
P P +QWL
Sbjct: 281 PQPHIQWL 288
Score = 36.6 bits (83), Expect = 0.12
Identities = 42/193 (21%), Positives = 66/193 (34%), Gaps = 36/193 (18%)
Query: 345 PPKGLPEPSVWWEHAGVRL-PTHG----RVYQKGHELVLANIAESDAGVYTCHAANLAGQ 399
P G P P++ W G P H +V +++ ++ SD G YTC N G
Sbjct: 177 PSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGS 236
Query: 400 RRQDVNITVATVPSWLKKPQDSQLEEGKPGYLD----------CLTQATPKPTVVWYR-- 447
+ V + P L+ G P C + P+P + W +
Sbjct: 237 INHTYQLDVVE-----RSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHI 291
Query: 448 --NQMLISEDSR--FEVFKNG----------TLRINSVEVYDGTWYRCMSSTPAGSIEAQ 493
N I D+ ++ K L + +V D Y C++ G
Sbjct: 292 EVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHS 351
Query: 494 ARVQVLEKLKFTP 506
A + VLE L+ P
Sbjct: 352 AWLTVLEALEERP 364
>gi|105990522 fibroblast growth factor receptor 1 isoform 1 precursor
[Homo sapiens]
Length = 822
Score = 207 bits (527), Expect = 4e-53
Identities = 184/737 (24%), Positives = 317/737 (43%), Gaps = 129/737 (17%)
Query: 353 SVWWEHAGVRLPTHGRVYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVA-TV 411
S+ W GV+L R G E+ + + +D+G+Y C ++ +G ++ V+ +
Sbjct: 63 SINWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSDAL 122
Query: 412 PSWLKKPQDS-------QLEEGKPGYLD---------------------------CLTQA 437
PS D + + KP + C +
Sbjct: 123 PSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSG 182
Query: 438 TPKPTVVWYRNQMLISEDSRFEVFK----NGTLRINSVEVYDGTWYRCMSSTPAGSIEAQ 493
TP PT+ W +N D R +K ++ ++SV D Y C+ GSI
Sbjct: 183 TPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHT 242
Query: 494 ARVQVLEKLKFTPPPQP----QQCMEFDKEATVPCSATGREKPTIKWER---ADGSSL-P 545
++ V+E+ P Q + + C +P I+W + +GS + P
Sbjct: 243 YQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGP 302
Query: 546 E-----WVTDNAGT---------LHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVAVF 591
+ + AG LH V+ +DAG YTC+A N +H + V
Sbjct: 303 DNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIG---LSHHSAWLTVL 359
Query: 592 ITFKVEPERTT--------VYQGHTALLQCEAQGDPKPLIQWKDKPVPEESEGPGSPPPY 643
+ P T +Y L+ C +I +K K ++S+ +
Sbjct: 360 EALEERPAVMTSPLYLEIIIYCTGAFLISCMVGS----VIVYKMKSGTKKSDFHSQMAVH 415
Query: 644 KMIQTIGLSVGAAVAYIIAVL---GLMFYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQN 700
K+ ++I L V+ + G++ R + +G P+
Sbjct: 416 KLAKSIPLRRQVTVSADSSASMNSGVLLVRPSRLSS-----------------SGTPMLA 458
Query: 701 GQPSAEIQEEVALTSLGSGPAATNKRHSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQ 760
G E+ E+ + PR L LG+ FG+V LA+A
Sbjct: 459 GVSEYELPED--------------------PRWELPRDRLVLGKPLGEGCFGQVVLAEAI 498
Query: 761 GLEEGVAE--TLVLVKSLQSKDEQQQL-DFRRELEMFGKLN-HANVVRLLGLCREAEPHY 816
GL++ T V VK L+S ++ L D E+EM + H N++ LLG C + P Y
Sbjct: 499 GLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLY 558
Query: 817 MVLEYVDLGDLKQFLRISKSKDEKLKSQP-------LSTKQKVALCTQVALGMEHLSNNR 869
+++EY G+L+++L+ + + P LS+K V+ QVA GME+L++ +
Sbjct: 559 VIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKK 618
Query: 870 FVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEYY-HFRQAWVPLRWMSPEAILEGDFS 928
+H+DLAARN LV+ +K++ GL++D+++ +YY +P++WM+PEA+ + ++
Sbjct: 619 CIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYT 678
Query: 929 TKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCW 988
+SDVW+FGVL+WE+FT G P+ G +E+ L+ G R+ +P C ++LY +M+ CW
Sbjct: 679 HQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGH-RMDKPSNCTNELYMMMRDCW 737
Query: 989 ALSPKDRPSFSEIASAL 1005
P RP+F ++ L
Sbjct: 738 HAVPSQRPTFKQLVEDL 754
Score = 52.8 bits (125), Expect = 2e-06
Identities = 79/327 (24%), Positives = 124/327 (37%), Gaps = 71/327 (21%)
Query: 140 IQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSSKERNLTLRPAGPEHSGLYS 199
+ P + LRC + + + W RDG L++ SN T + E + ++ + P SGLY+
Sbjct: 45 VHPGDLLQLRCRLRDDVQ-SINWLRDGVQLAE--SNRTRITGEE-VEVQDSVPADSGLYA 100
Query: 200 CCAHSAFGQACSSQNFTLSIA----------DESFA-----------RVVLAPQDVVVAR 238
C S G + + +S A D+S + R+ +AP +
Sbjct: 101 CVTSSPSGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEK 160
Query: 239 YEEAM----------FHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRA--TVFANGSL 286
E+ + F C S P P+L+WL + +P H +A S+
Sbjct: 161 MEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGK-----EFKPDHRIGGYKVRYATWSI 215
Query: 287 LLTQVRPRNAGIYRCIGQGQRGPPIILEATLHLAEIEDMP--------LFEPRVFTAGSE 338
++ V P + G Y CI + + G + T L +E P L + GS
Sbjct: 216 IMDSVVPSDKGNYTCIVENEYGS---INHTYQLDVVERSPHRPILQAGLPANKTVALGSN 272
Query: 339 ERVTCLPPKGLPEPSVWW-EHAGVR--------------LPTHG-RVYQKGHELV-LANI 381
C P+P + W +H V L T G K E++ L N+
Sbjct: 273 VEFMCKVYSD-PQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNV 331
Query: 382 AESDAGVYTCHAANLAGQRRQDVNITV 408
+ DAG YTC A N G +TV
Sbjct: 332 SFEDAGEYTCLAGNSIGLSHHSAWLTV 358
Score = 47.0 bits (110), Expect = 9e-05
Identities = 51/246 (20%), Positives = 87/246 (35%), Gaps = 43/246 (17%)
Query: 48 RALLRCEVEAPGPVHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQ-DSGTFQCVAR-- 104
R LR +V++ + WL DG + ++ R G + D + DSG + CV
Sbjct: 54 RCRLRDDVQS-----INWLRDGVQLAESNRTRITGEEVEVQ--DSVPADSGLYACVTSSP 106
Query: 105 -------------------------DDVTGEEARSANASFNIKWIEAGPVVLKHPASEAE 139
DD + EE + N N + + +
Sbjct: 107 SGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKLH 166
Query: 140 IQPQTQ-VTLRCHIDGHPRPTYQWFRDGTPLSDGQ--SNHTVSSKERNLTLRPAGPEHSG 196
P + V +C G P PT +W ++G + V ++ + P G
Sbjct: 167 AVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKG 226
Query: 197 LYSCCAHSAFGQACSSQNFTLSIADESFARVVL---APQDVVVARYEEAMFHCQFSAQPP 253
Y+C + +G + + L + + S R +L P + VA F C+ + P
Sbjct: 227 NYTCIVENEYGSI--NHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQ 284
Query: 254 PSLQWL 259
P +QWL
Sbjct: 285 PHIQWL 290
Score = 36.6 bits (83), Expect = 0.12
Identities = 42/193 (21%), Positives = 66/193 (34%), Gaps = 36/193 (18%)
Query: 345 PPKGLPEPSVWWEHAGVRL-PTHG----RVYQKGHELVLANIAESDAGVYTCHAANLAGQ 399
P G P P++ W G P H +V +++ ++ SD G YTC N G
Sbjct: 179 PSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGS 238
Query: 400 RRQDVNITVATVPSWLKKPQDSQLEEGKPGYLD----------CLTQATPKPTVVWYR-- 447
+ V + P L+ G P C + P+P + W +
Sbjct: 239 INHTYQLDVVE-----RSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHI 293
Query: 448 --NQMLISEDSR--FEVFKNG----------TLRINSVEVYDGTWYRCMSSTPAGSIEAQ 493
N I D+ ++ K L + +V D Y C++ G
Sbjct: 294 EVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHS 353
Query: 494 ARVQVLEKLKFTP 506
A + VLE L+ P
Sbjct: 354 AWLTVLEALEERP 366
>gi|222144231 fibroblast growth factor receptor 2 isoform 3 precursor
[Homo sapiens]
Length = 769
Score = 206 bits (525), Expect = 7e-53
Identities = 191/765 (24%), Positives = 309/765 (40%), Gaps = 140/765 (18%)
Query: 329 EPRVFTA--GSEERVTCLPPKGLPEPSVW-WEHAGVRLPTHGRVYQKGHELVLANIAESD 385
+P V+ A G V CL L + +V W GV L + R G L + D
Sbjct: 46 QPEVYVAAPGESLEVRCL----LKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRD 101
Query: 386 AGVYTCHAANLAGQRRQD--VNITVAT------------------------VPSWLKKPQ 419
+G+Y C A+ VN+T A P W +
Sbjct: 102 SGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEK 161
Query: 420 DSQLEEGKPGY----LDCLTQATPKPTVVWYRNQMLISEDSRFEVFK----NGTLRINSV 471
+ P C P PT+ W +N ++ R +K + +L + SV
Sbjct: 162 MEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESV 221
Query: 472 EVYDGTWYRCMSSTPAGSIEAQARVQVLEKLKFTP------PPQPQQCMEFDKEATVPCS 525
D Y C+ GSI + V+E+ P P + D E C
Sbjct: 222 VPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFV--CK 279
Query: 526 ATGREKPTIKW----ERADGSSLPEWV------------TDNAGTLHFARVTRDDAGNYT 569
+P I+W E+ P+ + + NA L VT DAG Y
Sbjct: 280 VYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINSSNAEVLALFNVTEADAGEYI 339
Query: 570 CIASNGPQGQIRAHVQLTVAVFITFKVEPERTTVYQGHTALLQCEAQGDPKPLIQWKDKP 629
C SN GQ LTV PK ++K
Sbjct: 340 CKVSNYI-GQANQSAWLTVL-----------------------------PKQQAPGREKE 369
Query: 630 VPEESEGPGSPPPYKMIQTIGLSVGAAVAYIIAVLGLMFYCKKRCKAKRLQKQPE-GEEP 688
+ + P Y I + V ++ V+ C+ K K+P+ +P
Sbjct: 370 IT-------ASPDYLEIAIYCIGVFLIACMVVTVI--------LCRMKNTTKKPDFSSQP 414
Query: 689 EMECLNGGPLQNGQPSAEIQEEVALTSLGSGPAATNKRHSTSD----------------K 732
+ L Q + + ++ S T + ST+D K
Sbjct: 415 AVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPK 474
Query: 733 MHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQLDFR---R 789
FPR L LG+ FG+V +A+A G+++ + V V KD+ + D
Sbjct: 475 WEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVS 534
Query: 790 ELEMFGKLN-HANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKD-------EKL 841
E+EM + H N++ LLG C + P Y+++EY G+L+++LR + ++
Sbjct: 535 EMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRV 594
Query: 842 KSQPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYN 901
+ ++ K V+ Q+A GME+L++ + +H+DLAARN LV+ +K++ GL++D+ N
Sbjct: 595 PEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINN 654
Query: 902 SEYYH-FRQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVL 960
+YY +P++WM+PEA+ + ++ +SDVW+FGVLMWE+FT G P+ G +E+
Sbjct: 655 IDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELF 714
Query: 961 ADLQAGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASAL 1005
L+ G R+ +P C ++LY +M+ CW P RP+F ++ L
Sbjct: 715 KLLKEGH-RMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDL 758
Score = 51.6 bits (122), Expect = 4e-06
Identities = 80/337 (23%), Positives = 120/337 (35%), Gaps = 80/337 (23%)
Query: 132 KHPASEAEIQ---PQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSSKERNLTLR 188
K+ S+ E+ P + +RC + W +DG L G +N TV E L ++
Sbjct: 41 KYQISQPEVYVAAPGESLEVRCLLKD--AAVISWTKDGVHL--GPNNRTVLIGEY-LQIK 95
Query: 189 PAGPEHSGLYSCCAHSAFGQACSSQNFTLSIAD--------------ESF----ARVVLA 230
A P SGLY+C A + F +++ D E F + A
Sbjct: 96 GATPRDSGLYACTASRTVDS--ETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRA 153
Query: 231 PQDVVVARYEEAM----------FHCQFSAQPPPSLQWL-----FEDETPITN-RSRPPH 274
P + E+ + F C P P+++WL F+ E I + R H
Sbjct: 154 PYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQH 213
Query: 275 LRRATVFANGSLLLTQVRPRNAGIYRCIGQGQRGPPIILEATLHLAEIEDMP-------- 326
SL++ V P + G Y C+ + + G + T HL +E P
Sbjct: 214 ---------WSLIMESVVPSDKGNYTCVVENEYGS---INHTYHLDVVERSPHRPILQAG 261
Query: 327 LFEPRVFTAGSEERVTCLPPKGLPEPSVWW----EHAGVRLPTHGRVYQK---------- 372
L G + C +P + W E G + G Y K
Sbjct: 262 LPANASTVVGGDVEFVCKVYSD-AQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINSS 320
Query: 373 -GHELVLANIAESDAGVYTCHAANLAGQRRQDVNITV 408
L L N+ E+DAG Y C +N GQ Q +TV
Sbjct: 321 NAEVLALFNVTEADAGEYICKVSNYIGQANQSAWLTV 357
Score = 47.0 bits (110), Expect = 9e-05
Identities = 53/257 (20%), Positives = 87/257 (33%), Gaps = 41/257 (15%)
Query: 35 IKQPSSQDALQGRRALLRCEVEAPGPVHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQ 94
I QP A G +RC ++ + W DG + R G L +
Sbjct: 44 ISQPEVYVAAPGESLEVRCLLKDAAVIS--WTKDGVHLGPNNRTVLIGEYLQIKGATP-R 100
Query: 95 DSGTFQCVA------------------------RDDVTGEEARSANASFNIK---WIEAG 127
DSG + C A DD G E + S N + W
Sbjct: 101 DSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTE 160
Query: 128 PVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQ--SNHTVSSKERNL 185
+ + A A V RC G+P PT +W ++G + V ++ +L
Sbjct: 161 KMEKRLHAVPAA----NTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSL 216
Query: 186 TLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVL---APQDVVVARYEEA 242
+ P G Y+C + +G + + L + + S R +L P + +
Sbjct: 217 IMESVVPSDKGNYTCVVENEYGSI--NHTYHLDVVERSPHRPILQAGLPANASTVVGGDV 274
Query: 243 MFHCQFSAQPPPSLQWL 259
F C+ + P +QW+
Sbjct: 275 EFVCKVYSDAQPHIQWI 291
>gi|221316638 fibroblast growth factor receptor 2 isoform 2 precursor
[Homo sapiens]
Length = 822
Score = 206 bits (525), Expect = 7e-53
Identities = 191/765 (24%), Positives = 309/765 (40%), Gaps = 140/765 (18%)
Query: 329 EPRVFTA--GSEERVTCLPPKGLPEPSVW-WEHAGVRLPTHGRVYQKGHELVLANIAESD 385
+P V+ A G V CL L + +V W GV L + R G L + D
Sbjct: 46 QPEVYVAAPGESLEVRCL----LKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRD 101
Query: 386 AGVYTCHAANLAGQRRQD--VNITVAT------------------------VPSWLKKPQ 419
+G+Y C A+ VN+T A P W +
Sbjct: 102 SGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEK 161
Query: 420 DSQLEEGKPGY----LDCLTQATPKPTVVWYRNQMLISEDSRFEVFK----NGTLRINSV 471
+ P C P PT+ W +N ++ R +K + +L + SV
Sbjct: 162 MEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESV 221
Query: 472 EVYDGTWYRCMSSTPAGSIEAQARVQVLEKLKFTP------PPQPQQCMEFDKEATVPCS 525
D Y C+ GSI + V+E+ P P + D E C
Sbjct: 222 VPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFV--CK 279
Query: 526 ATGREKPTIKW----ERADGSSLPEWV------------TDNAGTLHFARVTRDDAGNYT 569
+P I+W E+ P+ + + NA L VT DAG Y
Sbjct: 280 VYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINSSNAEVLALFNVTEADAGEYI 339
Query: 570 CIASNGPQGQIRAHVQLTVAVFITFKVEPERTTVYQGHTALLQCEAQGDPKPLIQWKDKP 629
C SN GQ LTV PK ++K
Sbjct: 340 CKVSNYI-GQANQSAWLTVL-----------------------------PKQQAPGREKE 369
Query: 630 VPEESEGPGSPPPYKMIQTIGLSVGAAVAYIIAVLGLMFYCKKRCKAKRLQKQPE-GEEP 688
+ + P Y I + V ++ V+ C+ K K+P+ +P
Sbjct: 370 IT-------ASPDYLEIAIYCIGVFLIACMVVTVI--------LCRMKNTTKKPDFSSQP 414
Query: 689 EMECLNGGPLQNGQPSAEIQEEVALTSLGSGPAATNKRHSTSD----------------K 732
+ L Q + + ++ S T + ST+D K
Sbjct: 415 AVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPK 474
Query: 733 MHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQLDFR---R 789
FPR L LG+ FG+V +A+A G+++ + V V KD+ + D
Sbjct: 475 WEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVS 534
Query: 790 ELEMFGKLN-HANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKD-------EKL 841
E+EM + H N++ LLG C + P Y+++EY G+L+++LR + ++
Sbjct: 535 EMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRV 594
Query: 842 KSQPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYN 901
+ ++ K V+ Q+A GME+L++ + +H+DLAARN LV+ +K++ GL++D+ N
Sbjct: 595 PEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINN 654
Query: 902 SEYYH-FRQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVL 960
+YY +P++WM+PEA+ + ++ +SDVW+FGVLMWE+FT G P+ G +E+
Sbjct: 655 IDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELF 714
Query: 961 ADLQAGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASAL 1005
L+ G R+ +P C ++LY +M+ CW P RP+F ++ L
Sbjct: 715 KLLKEGH-RMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDL 758
Score = 51.6 bits (122), Expect = 4e-06
Identities = 80/337 (23%), Positives = 120/337 (35%), Gaps = 80/337 (23%)
Query: 132 KHPASEAEIQ---PQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSSKERNLTLR 188
K+ S+ E+ P + +RC + W +DG L G +N TV E L ++
Sbjct: 41 KYQISQPEVYVAAPGESLEVRCLLKD--AAVISWTKDGVHL--GPNNRTVLIGEY-LQIK 95
Query: 189 PAGPEHSGLYSCCAHSAFGQACSSQNFTLSIAD--------------ESF----ARVVLA 230
A P SGLY+C A + F +++ D E F + A
Sbjct: 96 GATPRDSGLYACTASRTVDS--ETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRA 153
Query: 231 PQDVVVARYEEAM----------FHCQFSAQPPPSLQWL-----FEDETPITN-RSRPPH 274
P + E+ + F C P P+++WL F+ E I + R H
Sbjct: 154 PYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQH 213
Query: 275 LRRATVFANGSLLLTQVRPRNAGIYRCIGQGQRGPPIILEATLHLAEIEDMP-------- 326
SL++ V P + G Y C+ + + G + T HL +E P
Sbjct: 214 ---------WSLIMESVVPSDKGNYTCVVENEYGS---INHTYHLDVVERSPHRPILQAG 261
Query: 327 LFEPRVFTAGSEERVTCLPPKGLPEPSVWW----EHAGVRLPTHGRVYQK---------- 372
L G + C +P + W E G + G Y K
Sbjct: 262 LPANASTVVGGDVEFVCKVYSD-AQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINSS 320
Query: 373 -GHELVLANIAESDAGVYTCHAANLAGQRRQDVNITV 408
L L N+ E+DAG Y C +N GQ Q +TV
Sbjct: 321 NAEVLALFNVTEADAGEYICKVSNYIGQANQSAWLTV 357
Score = 47.0 bits (110), Expect = 9e-05
Identities = 53/257 (20%), Positives = 87/257 (33%), Gaps = 41/257 (15%)
Query: 35 IKQPSSQDALQGRRALLRCEVEAPGPVHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQ 94
I QP A G +RC ++ + W DG + R G L +
Sbjct: 44 ISQPEVYVAAPGESLEVRCLLKDAAVIS--WTKDGVHLGPNNRTVLIGEYLQIKGATP-R 100
Query: 95 DSGTFQCVA------------------------RDDVTGEEARSANASFNIK---WIEAG 127
DSG + C A DD G E + S N + W
Sbjct: 101 DSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTE 160
Query: 128 PVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQ--SNHTVSSKERNL 185
+ + A A V RC G+P PT +W ++G + V ++ +L
Sbjct: 161 KMEKRLHAVPAA----NTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSL 216
Query: 186 TLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVL---APQDVVVARYEEA 242
+ P G Y+C + +G + + L + + S R +L P + +
Sbjct: 217 IMESVVPSDKGNYTCVVENEYGSI--NHTYHLDVVERSPHRPILQAGLPANASTVVGGDV 274
Query: 243 MFHCQFSAQPPPSLQWL 259
F C+ + P +QW+
Sbjct: 275 EFVCKVYSDAQPHIQWI 291
>gi|59889560 neurotrophic tyrosine kinase, receptor, type 3 isoform b
precursor [Homo sapiens]
Length = 825
Score = 206 bits (523), Expect = 1e-52
Identities = 181/649 (27%), Positives = 285/649 (43%), Gaps = 76/649 (11%)
Query: 404 VNITVATVPSWLKKPQDSQLEEGKPGYLDCLTQATPKPTVVWYRN--QMLISEDSRFEVF 461
+NI+ +P + + EG + C +P P V W Q + + +
Sbjct: 202 MNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWT 261
Query: 462 KNGTLRINSVEVY---DGTWYRCMSSTPAGSIEAQARVQVLEKLKFTPPPQPQQCMEFDK 518
+ + V V +G C++ G A + V + +P+ +E
Sbjct: 262 NVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPELRLEHCI 321
Query: 519 EATVPCSATGREKPTIKWERADGSSLPEWVTDNA----------GTLHFARVTRDDAGNY 568
E V G PT+ W +G L E + G L F + T + GNY
Sbjct: 322 EFVV----RGNPPPTLHWLH-NGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNY 376
Query: 569 TCIASNGPQGQIRAHVQLTVAVFITFKVEPERTTVYQGHTALLQCEAQGDPKPLIQWKDK 628
T IA N P G T+ + PE T + +L E P + K
Sbjct: 377 TLIAKN-PLGTANQ----TINGHFLKEPFPESTDNF-----ILFDEVSPTPPITVTHK-- 424
Query: 629 PVPEESEGPGSPPPYKMIQTIGLSVG---AAVAYIIAVLGLMFYCKKRCKAKRLQKQP-- 683
PEE T G+S+ AA A ++ V+ + K ++K K P
Sbjct: 425 --PEED-------------TFGVSIAVGLAAFACVLLVVLFVMINKYGRRSKFGMKGPVA 469
Query: 684 --EGEEPEMECLNGGPLQNGQPSA-EIQEEVALTSLGSGPAATNKRH-STSDKMHFPRSS 739
GEE L+ PS+ + + + + P N ++ H P +
Sbjct: 470 VISGEEDSASPLHHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTY 529
Query: 740 LQPITT--------LGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQLDFRREL 791
+Q I LG+ FG+VFLA+ L + LV VK+L+ + DF+RE
Sbjct: 530 VQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREA 589
Query: 792 EMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLR-------ISKSKDEKLKSQ 844
E+ L H ++V+ G+C + +P MV EY+ GDL +FLR I +
Sbjct: 590 ELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKG 649
Query: 845 PLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEY 904
L Q + + +Q+A GM +L++ FVH+DLA RNCLV A VK+ G+S+DVY+++Y
Sbjct: 650 ELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDY 709
Query: 905 YHF-RQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADL 963
Y +P+RWM PE+I+ F+T+SDVW+FGV++WE+FT+G+ P ++ EV+ +
Sbjct: 710 YRVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECI 769
Query: 964 QAGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSE---IASALGDST 1009
G+ L +P CP ++Y +M CW P+ R + E I ALG +T
Sbjct: 770 TQGRV-LERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHALGKAT 817
Score = 38.1 bits (87), Expect = 0.042
Identities = 44/170 (25%), Positives = 62/170 (36%), Gaps = 23/170 (13%)
Query: 336 GSEERVTCLPPKGLPEPSVWWEHAGVR-LPTH--GRVYQKGH--ELVLANIAESDAG-VY 389
G +TC G P P V W G++ + TH + H L L N+ D G
Sbjct: 224 GDNAVITC-NGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTL 282
Query: 390 TCHAANLAGQRRQDVNITVATVPSWLKKPQDSQLEEGKPGYLDCL---TQATPKPTVVWY 446
TC A N+ G V +TV P+ LEE + C+ + P PT+ W
Sbjct: 283 TCIAENVVGMSNASVALTV------YYPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWL 336
Query: 447 RNQMLISEDSRFEV-------FKNGTLRINSVEVYDGTWYRCMSSTPAGS 489
N + E V G L N Y+ Y ++ P G+
Sbjct: 337 HNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGT 386
Score = 33.9 bits (76), Expect = 0.80
Identities = 44/203 (21%), Positives = 72/203 (35%), Gaps = 22/203 (10%)
Query: 215 FTLSIADESFARVVLAPQDVVVARYEEAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPH 274
F ++I+ + ++ ++ V + A+ C S P P + W+ I + +
Sbjct: 200 FRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSI--NTHQTN 257
Query: 275 LRRATVFANGSLLLTQVRPRNAGIYRCIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFT 334
L V A L+ N CI + G + A + + PRV +
Sbjct: 258 LNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVG--------MSNASVALTVYYPPRVVS 309
Query: 335 AGSEE--RVTCLP--PKGLPEPSVWWEHAGVRLP----THGRVYQKGHE----LVLANIA 382
E C+ +G P P++ W H G L H YQ+G L+
Sbjct: 310 LEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPT 369
Query: 383 ESDAGVYTCHAANLAGQRRQDVN 405
+ G YT A N G Q +N
Sbjct: 370 HYNNGNYTLIAKNPLGTANQTIN 392
Score = 31.6 bits (70), Expect = 4.0
Identities = 41/180 (22%), Positives = 75/180 (41%), Gaps = 20/180 (11%)
Query: 45 QGRRALLRCEVEAPGPVHVYWLLDGAP---VQDTERRFAQGSSLSFAAVD-RLQDSG-TF 99
+G A++ C V W++ G T + +++ V+ +D+G T
Sbjct: 223 EGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTL 282
Query: 100 QCVARDDVTGEEARSANASFNIKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPRPT 159
C+A ++V G +NAS + + P V+ E ++ + +R G+P PT
Sbjct: 283 TCIA-ENVVG----MSNASVALT-VYYPPRVVSLEEPELRLEHCIEFVVR----GNPPPT 332
Query: 160 YQWFRDGTPLSDGQSNHTVSSKERNLT---LRPAGPEH--SGLYSCCAHSAFGQACSSQN 214
W +G PL + + H +E ++ L P H +G Y+ A + G A + N
Sbjct: 333 LHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQTIN 392
>gi|19924165 proto-oncogene c-ros-1 protein precursor [Homo sapiens]
Length = 2347
Score = 204 bits (519), Expect = 3e-52
Identities = 109/279 (39%), Positives = 165/279 (59%), Gaps = 11/279 (3%)
Query: 735 FPRSSLQPITTLGKSEFGEVFLAKAQG-LEEGVAETLVLVKSLQS-KDEQQQLDFRRELE 792
FPR L LG FGEV+ A L G E V VK+L+ +Q++++F +E
Sbjct: 1940 FPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAH 1999
Query: 793 MFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDEKLKSQPLSTKQKV 852
+ K NH N+++ LG+C EP Y++LE ++ GDL +LR K++ L+ V
Sbjct: 2000 LMSKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLR--KARMATFYGPLLTLVDLV 2057
Query: 853 ALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQ-----RQVKVSALGLSKDVYNSEYYHF 907
LC ++ G +L F+H+DLAARNCLVS + R VK+ GL++D+Y ++YY
Sbjct: 2058 DLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRK 2117
Query: 908 R-QAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAG 966
R + +P+RWM+PE++++G F+T+SDVW+FG+L+WE+ T G P+ ++ +VL +Q G
Sbjct: 2118 RGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTG 2177
Query: 967 KARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASAL 1005
RL P CP L+ LM +CWA P RP+F I L
Sbjct: 2178 -GRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQL 2215
>gi|222144241 fibroblast growth factor receptor 2 isoform 8 precursor
[Homo sapiens]
Length = 704
Score = 203 bits (516), Expect = 8e-52
Identities = 170/628 (27%), Positives = 276/628 (43%), Gaps = 106/628 (16%)
Query: 433 CLTQATPKPTVVWYRNQMLISEDSRFEVFK----NGTLRINSVEVYDGTWYRCMSSTPAG 488
C P PT+ W +N ++ R +K + +L + SV D Y C+ G
Sbjct: 64 CPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYG 123
Query: 489 SIEAQARVQVLEKLKFTP------PPQPQQCMEFDKEATVPCSATGREKPTIKWER---A 539
SI + V+E+ P P + D E C +P I+W +
Sbjct: 124 SINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFV--CKVYSDAQPHIQWIKHVEK 181
Query: 540 DGSS-----LPEW-VTDNAGT---------LHFARVTRDDAGNYTCIASNGPQGQIRAHV 584
+GS LP V AG L+ VT +DAG YTC+A N
Sbjct: 182 NGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGN---------- 231
Query: 585 QLTVAVFITFKVEPERTTVYQGHTALLQCEAQGDPKPLIQWKDKPVPEESEGPGSPPPYK 644
++ I+F H+A L P P + + P Y
Sbjct: 232 ----SIGISF------------HSAWLTV--------------LPAPGREKEITASPDYL 261
Query: 645 MIQTIGLSVGAAVAYIIAVLGLMFYCKKRCKAKRLQKQPE-GEEPEMECLNGGPLQNGQP 703
I + V ++ V+ C+ K K+P+ +P + L Q
Sbjct: 262 EIAIYCIGVFLIACMVVTVI--------LCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQV 313
Query: 704 SAEIQEE-------VALTSLGSGPAATNKRHSTSD-------KMHFPRSSLQPITTLGKS 749
SAE V +T+ S A T S+ K FPR L LG+
Sbjct: 314 SAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEG 373
Query: 750 EFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQLDFR---RELEMFGKLN-HANVVRL 805
FG+V +A+A G+++ + V V KD+ + D E+EM + H N++ L
Sbjct: 374 CFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINL 433
Query: 806 LGLCREAEPHYMVLEYVDLGDLKQFLRISKSKD-------EKLKSQPLSTKQKVALCTQV 858
LG C + P Y+++EY G+L+++LR + ++ + ++ K V+ Q+
Sbjct: 434 LGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQL 493
Query: 859 ALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEYYH-FRQAWVPLRWM 917
A GME+L++ + +H+DLAARN LV+ +K++ GL++D+ N +YY +P++WM
Sbjct: 494 ARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWM 553
Query: 918 SPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQPEGCP 977
+PEA+ + ++ +SDVW+FGVLMWE+FT G P+ G +E+ L+ G R+ +P C
Sbjct: 554 APEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGH-RMDKPANCT 612
Query: 978 SKLYRLMQRCWALSPKDRPSFSEIASAL 1005
++LY +M+ CW P RP+F ++ L
Sbjct: 613 NELYMMMRDCWHAVPSQRPTFKQLVEDL 640
Score = 43.9 bits (102), Expect = 8e-04
Identities = 26/119 (21%), Positives = 49/119 (41%), Gaps = 7/119 (5%)
Query: 146 VTLRCHIDGHPRPTYQWFRDGTPLSDGQ--SNHTVSSKERNLTLRPAGPEHSGLYSCCAH 203
V RC G+P PT +W ++G + V ++ +L + P G Y+C
Sbjct: 60 VKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVE 119
Query: 204 SAFGQACSSQNFTLSIADESFARVVL---APQDVVVARYEEAMFHCQFSAQPPPSLQWL 259
+ +G + + L + + S R +L P + + F C+ + P +QW+
Sbjct: 120 NEYGSI--NHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWI 176
>gi|222144237 fibroblast growth factor receptor 2 isoform 6 precursor
[Homo sapiens]
Length = 706
Score = 202 bits (513), Expect = 2e-51
Identities = 166/630 (26%), Positives = 275/630 (43%), Gaps = 108/630 (17%)
Query: 433 CLTQATPKPTVVWYRNQMLISEDSRFEVFK----NGTLRINSVEVYDGTWYRCMSSTPAG 488
C P PT+ W +N ++ R +K + +L + SV D Y C+ G
Sbjct: 64 CPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYG 123
Query: 489 SIEAQARVQVLEKLKFTP------PPQPQQCMEFDKEATVPCSATGREKPTIKWER---A 539
SI + V+E+ P P + D E C +P I+W +
Sbjct: 124 SINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFV--CKVYSDAQPHIQWIKHVEK 181
Query: 540 DGSS-----LPEW-VTDNAGT---------LHFARVTRDDAGNYTCIASNGPQGQIRAHV 584
+GS LP V AG L+ VT +DAG YTC+A N
Sbjct: 182 NGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGN---------- 231
Query: 585 QLTVAVFITFKVEPERTTVYQGHTALLQCEAQGDPKPLIQWKDKPVPEESEGPGSPPPYK 644
++ I+F H+A L P P + + P Y
Sbjct: 232 ----SIGISF------------HSAWLTV--------------LPAPGREKEITASPDYL 261
Query: 645 MIQTIGLSVGAAVAYIIAVLGLMFYCKKRCKAKRLQKQPE-GEEPEMECLNGGPLQNGQP 703
I + V ++ V+ C+ K K+P+ +P + L Q
Sbjct: 262 EIAIYCIGVFLIACMVVTVI--------LCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQV 313
Query: 704 SAEIQEEVALTSLGSGPAATNKRHSTSD----------------KMHFPRSSLQPITTLG 747
+ + ++ S T + ST+D K FPR L LG
Sbjct: 314 TVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLG 373
Query: 748 KSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQLDFR---RELEMFGKLN-HANVV 803
+ FG+V +A+A G+++ + V V KD+ + D E+EM + H N++
Sbjct: 374 EGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNII 433
Query: 804 RLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKD-------EKLKSQPLSTKQKVALCT 856
LLG C + P Y+++EY G+L+++LR + ++ + ++ K V+
Sbjct: 434 NLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTY 493
Query: 857 QVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEYYH-FRQAWVPLR 915
Q+A GME+L++ + +H+DLAARN LV+ +K++ GL++D+ N +YY +P++
Sbjct: 494 QLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVK 553
Query: 916 WMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQPEG 975
WM+PEA+ + ++ +SDVW+FGVLMWE+FT G P+ G +E+ L+ G R+ +P
Sbjct: 554 WMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGH-RMDKPAN 612
Query: 976 CPSKLYRLMQRCWALSPKDRPSFSEIASAL 1005
C ++LY +M+ CW P RP+F ++ L
Sbjct: 613 CTNELYMMMRDCWHAVPSQRPTFKQLVEDL 642
Score = 43.9 bits (102), Expect = 8e-04
Identities = 26/119 (21%), Positives = 49/119 (41%), Gaps = 7/119 (5%)
Query: 146 VTLRCHIDGHPRPTYQWFRDGTPLSDGQ--SNHTVSSKERNLTLRPAGPEHSGLYSCCAH 203
V RC G+P PT +W ++G + V ++ +L + P G Y+C
Sbjct: 60 VKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVE 119
Query: 204 SAFGQACSSQNFTLSIADESFARVVL---APQDVVVARYEEAMFHCQFSAQPPPSLQWL 259
+ +G + + L + + S R +L P + + F C+ + P +QW+
Sbjct: 120 NEYGSI--NHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWI 176
>gi|222144235 fibroblast growth factor receptor 2 isoform 5 precursor
[Homo sapiens]
Length = 707
Score = 202 bits (513), Expect = 2e-51
Identities = 166/630 (26%), Positives = 275/630 (43%), Gaps = 108/630 (17%)
Query: 433 CLTQATPKPTVVWYRNQMLISEDSRFEVFK----NGTLRINSVEVYDGTWYRCMSSTPAG 488
C P PT+ W +N ++ R +K + +L + SV D Y C+ G
Sbjct: 90 CPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYG 149
Query: 489 SIEAQARVQVLEKLKFTP------PPQPQQCMEFDKEATVPCSATGREKPTIKWER---A 539
SI + V+E+ P P + D E C +P I+W +
Sbjct: 150 SINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFV--CKVYSDAQPHIQWIKHVEK 207
Query: 540 DGSS-----LPEW-VTDNAGT---------LHFARVTRDDAGNYTCIASNGPQGQIRAHV 584
+GS LP V AG L+ VT +DAG YTC+A N
Sbjct: 208 NGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGN---------- 257
Query: 585 QLTVAVFITFKVEPERTTVYQGHTALLQCEAQGDPKPLIQWKDKPVPEESEGPGSPPPYK 644
++ I+F H+A L P P + + P Y
Sbjct: 258 ----SIGISF------------HSAWLTV--------------LPAPGREKEITASPDYL 287
Query: 645 MIQTIGLSVGAAVAYIIAVLGLMFYCKKRCKAKRLQKQPE-GEEPEMECLNGGPLQNGQP 703
I + V ++ V+ C+ K K+P+ +P + L Q
Sbjct: 288 EIAIYCIGVFLIACMVVTVI--------LCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQV 339
Query: 704 SAEIQEEVALTSLGSGPAATNKRHSTSD----------------KMHFPRSSLQPITTLG 747
+ + ++ S T + ST+D K FPR L LG
Sbjct: 340 TVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLG 399
Query: 748 KSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQLDFR---RELEMFGKLN-HANVV 803
+ FG+V +A+A G+++ + V V KD+ + D E+EM + H N++
Sbjct: 400 EGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNII 459
Query: 804 RLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKD-------EKLKSQPLSTKQKVALCT 856
LLG C + P Y+++EY G+L+++LR + ++ + ++ K V+
Sbjct: 460 NLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTY 519
Query: 857 QVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEYYH-FRQAWVPLR 915
Q+A GME+L++ + +H+DLAARN LV+ +K++ GL++D+ N +YY +P++
Sbjct: 520 QLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVK 579
Query: 916 WMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQPEG 975
WM+PEA+ + ++ +SDVW+FGVLMWE+FT G P+ G +E+ L+ G R+ +P
Sbjct: 580 WMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGH-RMDKPAN 638
Query: 976 CPSKLYRLMQRCWALSPKDRPSFSEIASAL 1005
C ++LY +M+ CW P RP+F ++ L
Sbjct: 639 CTNELYMMMRDCWHAVPSQRPTFKQLVEDL 668
Score = 43.9 bits (102), Expect = 8e-04
Identities = 26/119 (21%), Positives = 49/119 (41%), Gaps = 7/119 (5%)
Query: 146 VTLRCHIDGHPRPTYQWFRDGTPLSDGQ--SNHTVSSKERNLTLRPAGPEHSGLYSCCAH 203
V RC G+P PT +W ++G + V ++ +L + P G Y+C
Sbjct: 86 VKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVE 145
Query: 204 SAFGQACSSQNFTLSIADESFARVVL---APQDVVVARYEEAMFHCQFSAQPPPSLQWL 259
+ +G + + L + + S R +L P + + F C+ + P +QW+
Sbjct: 146 NEYGSI--NHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWI 202
>gi|13186236 fibroblast growth factor receptor 1 isoform 4 precursor
[Homo sapiens]
Length = 731
Score = 201 bits (511), Expect = 3e-51
Identities = 165/622 (26%), Positives = 280/622 (45%), Gaps = 94/622 (15%)
Query: 433 CLTQATPKPTVVWYRNQMLISEDSRFEVFK----NGTLRINSVEVYDGTWYRCMSSTPAG 488
C + TP PT+ W +N D R +K ++ ++SV D Y C+ G
Sbjct: 87 CPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYG 146
Query: 489 SIEAQARVQVLEKLKFTPPPQP----QQCMEFDKEATVPCSATGREKPTIKWER---ADG 541
SI ++ V+E+ P Q + + C +P I+W + +G
Sbjct: 147 SINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNG 206
Query: 542 SSL-PE-----WVTDNAGT---------LHFARVTRDDAGNYTCIASNGPQGQIRAHVQL 586
S + P+ + AG LH V+ +DAG YTC+A N +H
Sbjct: 207 SKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIG---LSHHSA 263
Query: 587 TVAVFITFKVEPERTT--------VYQGHTALLQCEAQGDPKPLIQWKDKPVPEESEGPG 638
+ V + P T +Y L+ C +I +K K ++S+
Sbjct: 264 WLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMVGS----VIVYKMKSGTKKSDFHS 319
Query: 639 SPPPYKMIQTIGLSVGAAVAYIIAVL---GLMFYCKKRCKAKRLQKQPEGEEPEMECLNG 695
+K+ ++I L V+ + G++ R + +G
Sbjct: 320 QMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVRPSRLSS-----------------SG 362
Query: 696 GPLQNGQPSAEIQEEVALTSLGSGPAATNKRHSTSDKMHFPRSSLQPITTLGKSEFGEVF 755
P+ G E+ E+ + PR L LG+ FG+V
Sbjct: 363 TPMLAGVSEYELPED--------------------PRWELPRDRLVLGKPLGEGCFGQVV 402
Query: 756 LAKAQGLEEGVAE--TLVLVKSLQSKDEQQQL-DFRRELEMFGKLN-HANVVRLLGLCRE 811
LA+A GL++ T V VK L+S ++ L D E+EM + H N++ LLG C +
Sbjct: 403 LAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQ 462
Query: 812 AEPHYMVLEYVDLGDLKQFLRISKSKDEKLKSQP-------LSTKQKVALCTQVALGMEH 864
P Y+++EY G+L+++L+ + + P LS+K V+ QVA GME+
Sbjct: 463 DGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEY 522
Query: 865 LSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEYY-HFRQAWVPLRWMSPEAIL 923
L++ + +H+DLAARN LV+ +K++ GL++D+++ +YY +P++WM+PEA+
Sbjct: 523 LASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALF 582
Query: 924 EGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQPEGCPSKLYRL 983
+ ++ +SDVW+FGVL+WE+FT G P+ G +E+ L+ G R+ +P C ++LY +
Sbjct: 583 DRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGH-RMDKPSNCTNELYMM 641
Query: 984 MQRCWALSPKDRPSFSEIASAL 1005
M+ CW P RP+F ++ L
Sbjct: 642 MRDCWHAVPSQRPTFKQLVEDL 663
Score = 48.5 bits (114), Expect = 3e-05
Identities = 40/147 (27%), Positives = 58/147 (39%), Gaps = 13/147 (8%)
Query: 518 KEATVPCSATGREKPTIKWERADGSSLPEW------VTDNAGTLHFARVTRDDAGNYTCI 571
K C ++G PT++W + P+ V ++ V D GNYTCI
Sbjct: 81 KTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCI 140
Query: 572 ASNGPQGQIRAHVQLTVAVFITFKVE-----PERTTVYQGHTALLQCEAQGDPKPLIQW- 625
N G I QL V + P TV G C+ DP+P IQW
Sbjct: 141 VEN-EYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWL 199
Query: 626 KDKPVPEESEGPGSPPPYKMIQTIGLS 652
K V GP + P ++++T G++
Sbjct: 200 KHIEVNGSKIGPDNLPYVQILKTAGVN 226
Score = 46.2 bits (108), Expect = 2e-04
Identities = 28/119 (23%), Positives = 48/119 (40%), Gaps = 7/119 (5%)
Query: 146 VTLRCHIDGHPRPTYQWFRDGTPLSDGQ--SNHTVSSKERNLTLRPAGPEHSGLYSCCAH 203
V +C G P PT +W ++G + V ++ + P G Y+C
Sbjct: 83 VKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVE 142
Query: 204 SAFGQACSSQNFTLSIADESFARVVL---APQDVVVARYEEAMFHCQFSAQPPPSLQWL 259
+ +G + + L + + S R +L P + VA F C+ + P P +QWL
Sbjct: 143 NEYGSI--NHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWL 199
Score = 40.8 bits (94), Expect = 0.007
Identities = 50/192 (26%), Positives = 72/192 (37%), Gaps = 36/192 (18%)
Query: 244 FHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRA--TVFANGSLLLTQVRPRNAGIYRC 301
F C S P P+L+WL + +P H +A S+++ V P + G Y C
Sbjct: 85 FKCPSSGTPNPTLRWLKNGK-----EFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTC 139
Query: 302 IGQGQRGPPIILEATLHLAEIEDMP--------LFEPRVFTAGSEERVTCLPPKGLPEPS 353
I + + G + T L +E P L + GS C P+P
Sbjct: 140 IVENEYGS---INHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSD-PQPH 195
Query: 354 VWW-EHAGVR--------------LPTHG-RVYQKGHELV-LANIAESDAGVYTCHAANL 396
+ W +H V L T G K E++ L N++ DAG YTC A N
Sbjct: 196 IQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNS 255
Query: 397 AGQRRQDVNITV 408
G +TV
Sbjct: 256 IGLSHHSAWLTV 267
Score = 36.6 bits (83), Expect = 0.12
Identities = 42/193 (21%), Positives = 66/193 (34%), Gaps = 36/193 (18%)
Query: 345 PPKGLPEPSVWWEHAGVRL-PTHG----RVYQKGHELVLANIAESDAGVYTCHAANLAGQ 399
P G P P++ W G P H +V +++ ++ SD G YTC N G
Sbjct: 88 PSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGS 147
Query: 400 RRQDVNITVATVPSWLKKPQDSQLEEGKPGYLD----------CLTQATPKPTVVWYR-- 447
+ V + P L+ G P C + P+P + W +
Sbjct: 148 INHTYQLDVVE-----RSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHI 202
Query: 448 --NQMLISEDSR--FEVFKNG----------TLRINSVEVYDGTWYRCMSSTPAGSIEAQ 493
N I D+ ++ K L + +V D Y C++ G
Sbjct: 203 EVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHS 262
Query: 494 ARVQVLEKLKFTP 506
A + VLE L+ P
Sbjct: 263 AWLTVLEALEERP 275
>gi|13186234 fibroblast growth factor receptor 1 isoform 3 precursor
[Homo sapiens]
Length = 733
Score = 201 bits (511), Expect = 3e-51
Identities = 165/622 (26%), Positives = 280/622 (45%), Gaps = 94/622 (15%)
Query: 433 CLTQATPKPTVVWYRNQMLISEDSRFEVFK----NGTLRINSVEVYDGTWYRCMSSTPAG 488
C + TP PT+ W +N D R +K ++ ++SV D Y C+ G
Sbjct: 89 CPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYG 148
Query: 489 SIEAQARVQVLEKLKFTPPPQP----QQCMEFDKEATVPCSATGREKPTIKWER---ADG 541
SI ++ V+E+ P Q + + C +P I+W + +G
Sbjct: 149 SINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNG 208
Query: 542 SSL-PE-----WVTDNAGT---------LHFARVTRDDAGNYTCIASNGPQGQIRAHVQL 586
S + P+ + AG LH V+ +DAG YTC+A N +H
Sbjct: 209 SKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIG---LSHHSA 265
Query: 587 TVAVFITFKVEPERTT--------VYQGHTALLQCEAQGDPKPLIQWKDKPVPEESEGPG 638
+ V + P T +Y L+ C +I +K K ++S+
Sbjct: 266 WLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMVGS----VIVYKMKSGTKKSDFHS 321
Query: 639 SPPPYKMIQTIGLSVGAAVAYIIAVL---GLMFYCKKRCKAKRLQKQPEGEEPEMECLNG 695
+K+ ++I L V+ + G++ R + +G
Sbjct: 322 QMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVRPSRLSS-----------------SG 364
Query: 696 GPLQNGQPSAEIQEEVALTSLGSGPAATNKRHSTSDKMHFPRSSLQPITTLGKSEFGEVF 755
P+ G E+ E+ + PR L LG+ FG+V
Sbjct: 365 TPMLAGVSEYELPED--------------------PRWELPRDRLVLGKPLGEGCFGQVV 404
Query: 756 LAKAQGLEEGVAE--TLVLVKSLQSKDEQQQL-DFRRELEMFGKLN-HANVVRLLGLCRE 811
LA+A GL++ T V VK L+S ++ L D E+EM + H N++ LLG C +
Sbjct: 405 LAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQ 464
Query: 812 AEPHYMVLEYVDLGDLKQFLRISKSKDEKLKSQP-------LSTKQKVALCTQVALGMEH 864
P Y+++EY G+L+++L+ + + P LS+K V+ QVA GME+
Sbjct: 465 DGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEY 524
Query: 865 LSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEYY-HFRQAWVPLRWMSPEAIL 923
L++ + +H+DLAARN LV+ +K++ GL++D+++ +YY +P++WM+PEA+
Sbjct: 525 LASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALF 584
Query: 924 EGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQPEGCPSKLYRL 983
+ ++ +SDVW+FGVL+WE+FT G P+ G +E+ L+ G R+ +P C ++LY +
Sbjct: 585 DRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGH-RMDKPSNCTNELYMM 643
Query: 984 MQRCWALSPKDRPSFSEIASAL 1005
M+ CW P RP+F ++ L
Sbjct: 644 MRDCWHAVPSQRPTFKQLVEDL 665
Score = 48.5 bits (114), Expect = 3e-05
Identities = 40/147 (27%), Positives = 58/147 (39%), Gaps = 13/147 (8%)
Query: 518 KEATVPCSATGREKPTIKWERADGSSLPEW------VTDNAGTLHFARVTRDDAGNYTCI 571
K C ++G PT++W + P+ V ++ V D GNYTCI
Sbjct: 83 KTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCI 142
Query: 572 ASNGPQGQIRAHVQLTVAVFITFKVE-----PERTTVYQGHTALLQCEAQGDPKPLIQW- 625
N G I QL V + P TV G C+ DP+P IQW
Sbjct: 143 VEN-EYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWL 201
Query: 626 KDKPVPEESEGPGSPPPYKMIQTIGLS 652
K V GP + P ++++T G++
Sbjct: 202 KHIEVNGSKIGPDNLPYVQILKTAGVN 228
Score = 46.2 bits (108), Expect = 2e-04
Identities = 28/119 (23%), Positives = 48/119 (40%), Gaps = 7/119 (5%)
Query: 146 VTLRCHIDGHPRPTYQWFRDGTPLSDGQ--SNHTVSSKERNLTLRPAGPEHSGLYSCCAH 203
V +C G P PT +W ++G + V ++ + P G Y+C
Sbjct: 85 VKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVE 144
Query: 204 SAFGQACSSQNFTLSIADESFARVVL---APQDVVVARYEEAMFHCQFSAQPPPSLQWL 259
+ +G + + L + + S R +L P + VA F C+ + P P +QWL
Sbjct: 145 NEYGSI--NHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWL 201
Score = 40.8 bits (94), Expect = 0.007
Identities = 50/192 (26%), Positives = 72/192 (37%), Gaps = 36/192 (18%)
Query: 244 FHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRA--TVFANGSLLLTQVRPRNAGIYRC 301
F C S P P+L+WL + +P H +A S+++ V P + G Y C
Sbjct: 87 FKCPSSGTPNPTLRWLKNGK-----EFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTC 141
Query: 302 IGQGQRGPPIILEATLHLAEIEDMP--------LFEPRVFTAGSEERVTCLPPKGLPEPS 353
I + + G + T L +E P L + GS C P+P
Sbjct: 142 IVENEYGS---INHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSD-PQPH 197
Query: 354 VWW-EHAGVR--------------LPTHG-RVYQKGHELV-LANIAESDAGVYTCHAANL 396
+ W +H V L T G K E++ L N++ DAG YTC A N
Sbjct: 198 IQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNS 257
Query: 397 AGQRRQDVNITV 408
G +TV
Sbjct: 258 IGLSHHSAWLTV 269
Score = 36.6 bits (83), Expect = 0.12
Identities = 42/193 (21%), Positives = 66/193 (34%), Gaps = 36/193 (18%)
Query: 345 PPKGLPEPSVWWEHAGVRL-PTHG----RVYQKGHELVLANIAESDAGVYTCHAANLAGQ 399
P G P P++ W G P H +V +++ ++ SD G YTC N G
Sbjct: 90 PSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGS 149
Query: 400 RRQDVNITVATVPSWLKKPQDSQLEEGKPGYLD----------CLTQATPKPTVVWYR-- 447
+ V + P L+ G P C + P+P + W +
Sbjct: 150 INHTYQLDVVE-----RSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHI 204
Query: 448 --NQMLISEDSR--FEVFKNG----------TLRINSVEVYDGTWYRCMSSTPAGSIEAQ 493
N I D+ ++ K L + +V D Y C++ G
Sbjct: 205 EVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHS 264
Query: 494 ARVQVLEKLKFTP 506
A + VLE L+ P
Sbjct: 265 AWLTVLEALEERP 277
>gi|222144244 fibroblast growth factor receptor 2 isoform 9 precursor
[Homo sapiens]
Length = 680
Score = 201 bits (510), Expect = 4e-51
Identities = 163/628 (25%), Positives = 269/628 (42%), Gaps = 103/628 (16%)
Query: 433 CLTQATPKPTVVWYRNQMLISEDSRFEVFK----NGTLRINSVEVYDGTWYRCMSSTPAG 488
C P PT+ W +N ++ R +K + +L + SV D Y C+ G
Sbjct: 90 CPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYG 149
Query: 489 SIEAQARVQVLEKLKFTP------PPQPQQCMEFDKEATVPCSATGREKPTIKW----ER 538
SI + V+E+ P P + D E C +P I+W E+
Sbjct: 150 SINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFV--CKVYSDAQPHIQWIKHVEK 207
Query: 539 ADGSSLPEWV------------TDNAGTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQL 586
P+ + + NA L VT DAG Y C SN GQ L
Sbjct: 208 NGSKYGPDGLPYLKVLKHSGINSSNAEVLALFNVTEADAGEYICKVSNYI-GQANQSAWL 266
Query: 587 TVAVFITFKVEPERTTVYQGHTALLQCEAQGDPKPLIQWKDKPVPEESEGPGSPPPYKMI 646
TV PK ++K + + P Y I
Sbjct: 267 TVL-----------------------------PKQQAPGREKEIT-------ASPDYLEI 290
Query: 647 QTIGLSVGAAVAYIIAVLGLMFYCKKRCKAKRLQKQPE-GEEPEMECLNGGPLQNGQPSA 705
+ V ++ V+ C+ K K+P+ +P + L Q +
Sbjct: 291 AIYCIGVFLIACMVVTVI--------LCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTV 342
Query: 706 EIQEEVALTSLGSGPAATNKRHSTSD----------------KMHFPRSSLQPITTLGKS 749
+ ++ S T + ST+D K FPR L LG+
Sbjct: 343 SAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEG 402
Query: 750 EFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQLDFR---RELEMFGKLN-HANVVRL 805
FG+V +A+A G+++ + V V KD+ + D E+EM + H N++ L
Sbjct: 403 CFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINL 462
Query: 806 LGLCREAEPHYMVLEYVDLGDLKQFLRISKSKD-------EKLKSQPLSTKQKVALCTQV 858
LG C + P Y+++EY G+L+++LR + ++ + ++ K V+ Q+
Sbjct: 463 LGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQL 522
Query: 859 ALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEYYH-FRQAWVPLRWM 917
A GME+L++ + +H+DLAARN LV+ +K++ GL++D+ N +YY +P++WM
Sbjct: 523 ARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWM 582
Query: 918 SPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQPEGCP 977
+PEA+ + ++ +SDVW+FGVLMWE+FT G P+ G +E+ L+ G R+ +P C
Sbjct: 583 APEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGH-RMDKPANCT 641
Query: 978 SKLYRLMQRCWALSPKDRPSFSEIASAL 1005
++LY +M+ CW P RP+F ++ L
Sbjct: 642 NELYMMMRDCWHAVPSQRPTFKQLVEDL 669
Score = 44.7 bits (104), Expect = 5e-04
Identities = 48/193 (24%), Positives = 68/193 (35%), Gaps = 40/193 (20%)
Query: 244 FHCQFSAQPPPSLQWL-----FEDETPITN-RSRPPHLRRATVFANGSLLLTQVRPRNAG 297
F C P P+++WL F+ E I + R H SL++ V P + G
Sbjct: 88 FRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHW---------SLIMESVVPSDKG 138
Query: 298 IYRCIGQGQRGPPIILEATLHLAEIEDMP--------LFEPRVFTAGSEERVTCLPPKGL 349
Y C+ + + G + T HL +E P L G + C
Sbjct: 139 NYTCVVENEYGS---INHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDA 195
Query: 350 PEPSVWWEHA---GVRLPTHGRVYQK-----------GHELVLANIAESDAGVYTCHAAN 395
W +H G + G Y K L L N+ E+DAG Y C +N
Sbjct: 196 QPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINSSNAEVLALFNVTEADAGEYICKVSN 255
Query: 396 LAGQRRQDVNITV 408
GQ Q +TV
Sbjct: 256 YIGQANQSAWLTV 268
Score = 43.9 bits (102), Expect = 8e-04
Identities = 26/119 (21%), Positives = 49/119 (41%), Gaps = 7/119 (5%)
Query: 146 VTLRCHIDGHPRPTYQWFRDGTPLSDGQ--SNHTVSSKERNLTLRPAGPEHSGLYSCCAH 203
V RC G+P PT +W ++G + V ++ +L + P G Y+C
Sbjct: 86 VKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVE 145
Query: 204 SAFGQACSSQNFTLSIADESFARVVL---APQDVVVARYEEAMFHCQFSAQPPPSLQWL 259
+ +G + + L + + S R +L P + + F C+ + P +QW+
Sbjct: 146 NEYGSI--NHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWI 202
>gi|59889562 neurotrophic tyrosine kinase, receptor, type 3 isoform a
precursor [Homo sapiens]
Length = 839
Score = 201 bits (510), Expect = 4e-51
Identities = 181/663 (27%), Positives = 285/663 (42%), Gaps = 90/663 (13%)
Query: 404 VNITVATVPSWLKKPQDSQLEEGKPGYLDCLTQATPKPTVVWYRN--QMLISEDSRFEVF 461
+NI+ +P + + EG + C +P P V W Q + + +
Sbjct: 202 MNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWT 261
Query: 462 KNGTLRINSVEVY---DGTWYRCMSSTPAGSIEAQARVQVLEKLKFTPPPQPQQCMEFDK 518
+ + V V +G C++ G A + V + +P+ +E
Sbjct: 262 NVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPELRLEHCI 321
Query: 519 EATVPCSATGREKPTIKWERADGSSLPEWVTDNA----------GTLHFARVTRDDAGNY 568
E V G PT+ W +G L E + G L F + T + GNY
Sbjct: 322 EFVV----RGNPPPTLHWLH-NGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNY 376
Query: 569 TCIASNGPQGQIRAHVQLTVAVFITFKVEPERTTVYQGHTALLQCEAQGDPKPLIQWKDK 628
T IA N P G T+ + PE T + +L E P + K
Sbjct: 377 TLIAKN-PLGTANQ----TINGHFLKEPFPESTDNF-----ILFDEVSPTPPITVTHK-- 424
Query: 629 PVPEESEGPGSPPPYKMIQTIGLSVG---AAVAYIIAVLGLMFYCKKRCKAKRLQKQP-- 683
PEE T G+S+ AA A ++ V+ + K ++K K P
Sbjct: 425 --PEED-------------TFGVSIAVGLAAFACVLLVVLFVMINKYGRRSKFGMKGPVA 469
Query: 684 --EGEEPEMECLNGGPLQNGQPSA-EIQEEVALTSLGSGPAATNKRH-STSDKMHFPRSS 739
GEE L+ PS+ + + + + P N ++ H P +
Sbjct: 470 VISGEEDSASPLHHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTY 529
Query: 740 LQPITT--------LGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQLDFRREL 791
+Q I LG+ FG+VFLA+ L + LV VK+L+ + DF+RE
Sbjct: 530 VQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREA 589
Query: 792 EMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLR-------ISKSKDEKLKSQ 844
E+ L H ++V+ G+C + +P MV EY+ GDL +FLR I +
Sbjct: 590 ELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKG 649
Query: 845 PLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEY 904
L Q + + +Q+A GM +L++ FVH+DLA RNCLV A VK+ G+S+DVY+++Y
Sbjct: 650 ELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDY 709
Query: 905 YHF---------------RQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEM 949
Y +P+RWM PE+I+ F+T+SDVW+FGV++WE+FT+G+
Sbjct: 710 YRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQ 769
Query: 950 PHGGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSE---IASALG 1006
P ++ EV+ + G+ L +P CP ++Y +M CW P+ R + E I ALG
Sbjct: 770 PWFQLSNTEVIECITQGRV-LERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHALG 828
Query: 1007 DST 1009
+T
Sbjct: 829 KAT 831
Score = 38.1 bits (87), Expect = 0.042
Identities = 44/170 (25%), Positives = 62/170 (36%), Gaps = 23/170 (13%)
Query: 336 GSEERVTCLPPKGLPEPSVWWEHAGVR-LPTH--GRVYQKGH--ELVLANIAESDAG-VY 389
G +TC G P P V W G++ + TH + H L L N+ D G
Sbjct: 224 GDNAVITC-NGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTL 282
Query: 390 TCHAANLAGQRRQDVNITVATVPSWLKKPQDSQLEEGKPGYLDCL---TQATPKPTVVWY 446
TC A N+ G V +TV P+ LEE + C+ + P PT+ W
Sbjct: 283 TCIAENVVGMSNASVALTV------YYPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWL 336
Query: 447 RNQMLISEDSRFEV-------FKNGTLRINSVEVYDGTWYRCMSSTPAGS 489
N + E V G L N Y+ Y ++ P G+
Sbjct: 337 HNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGT 386
Score = 33.9 bits (76), Expect = 0.80
Identities = 44/203 (21%), Positives = 72/203 (35%), Gaps = 22/203 (10%)
Query: 215 FTLSIADESFARVVLAPQDVVVARYEEAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPH 274
F ++I+ + ++ ++ V + A+ C S P P + W+ I + +
Sbjct: 200 FRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSI--NTHQTN 257
Query: 275 LRRATVFANGSLLLTQVRPRNAGIYRCIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFT 334
L V A L+ N CI + G + A + + PRV +
Sbjct: 258 LNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVG--------MSNASVALTVYYPPRVVS 309
Query: 335 AGSEE--RVTCLP--PKGLPEPSVWWEHAGVRLP----THGRVYQKGHE----LVLANIA 382
E C+ +G P P++ W H G L H YQ+G L+
Sbjct: 310 LEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPT 369
Query: 383 ESDAGVYTCHAANLAGQRRQDVN 405
+ G YT A N G Q +N
Sbjct: 370 HYNNGNYTLIAKNPLGTANQTIN 392
Score = 31.6 bits (70), Expect = 4.0
Identities = 41/180 (22%), Positives = 75/180 (41%), Gaps = 20/180 (11%)
Query: 45 QGRRALLRCEVEAPGPVHVYWLLDGAP---VQDTERRFAQGSSLSFAAVD-RLQDSG-TF 99
+G A++ C V W++ G T + +++ V+ +D+G T
Sbjct: 223 EGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTL 282
Query: 100 QCVARDDVTGEEARSANASFNIKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPRPT 159
C+A ++V G +NAS + + P V+ E ++ + +R G+P PT
Sbjct: 283 TCIA-ENVVG----MSNASVALT-VYYPPRVVSLEEPELRLEHCIEFVVR----GNPPPT 332
Query: 160 YQWFRDGTPLSDGQSNHTVSSKERNLT---LRPAGPEH--SGLYSCCAHSAFGQACSSQN 214
W +G PL + + H +E ++ L P H +G Y+ A + G A + N
Sbjct: 333 LHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQTIN 392
>gi|42544153 leukocyte receptor tyrosine kinase isoform 1 precursor
[Homo sapiens]
Length = 864
Score = 199 bits (507), Expect = 8e-51
Identities = 107/274 (39%), Positives = 156/274 (56%), Gaps = 8/274 (2%)
Query: 743 ITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSK-DEQQQLDFRRELEMFGKLNHAN 801
+ LG FGEV+ GL + V +K+L Q +LDF E + K H N
Sbjct: 513 LRALGHGAFGEVYEGLVIGLPGDSSPLQVAIKTLPELCSPQDELDFLMEALIISKFRHQN 572
Query: 802 VVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDEKLKSQPLSTKQKVALCTQVALG 861
+VR +GL A P ++LE + GD+K FLR S+ + PL + + L +A G
Sbjct: 573 IVRCVGLSLRATPRLILLELMSGGDMKSFLR--HSRPHLGQPSPLVMRDLLQLAQDIAQG 630
Query: 862 MEHLSNNRFVHKDLAARNCLVSA---QRQVKVSALGLSKDVYNSEYYHFR-QAWVPLRWM 917
+L N F+H+D+AARNCL+S R K+ G+++D+Y + YY +A +P++WM
Sbjct: 631 CHYLEENHFIHRDIAARNCLLSCAGPSRVAKIGDFGMARDIYRASYYRRGDRALLPVKWM 690
Query: 918 SPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQPEGCP 977
PEA LEG F++K+D W+FGVL+WE+F+ G MP+ G+ + EVL D G R+ P GCP
Sbjct: 691 PPEAFLEGIFTSKTDSWSFGVLLWEIFSLGYMPYPGRTNQEVL-DFVVGGGRMDPPRGCP 749
Query: 978 SKLYRLMQRCWALSPKDRPSFSEIASALGDSTVD 1011
+YR+M +CW P+ RPSF+ I L T D
Sbjct: 750 GPVYRIMTQCWQHEPELRPSFASILERLQYCTQD 783
>gi|46249416 leukocyte receptor tyrosine kinase isoform 2 precursor
[Homo sapiens]
Length = 803
Score = 199 bits (507), Expect = 8e-51
Identities = 107/274 (39%), Positives = 156/274 (56%), Gaps = 8/274 (2%)
Query: 743 ITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSK-DEQQQLDFRRELEMFGKLNHAN 801
+ LG FGEV+ GL + V +K+L Q +LDF E + K H N
Sbjct: 452 LRALGHGAFGEVYEGLVIGLPGDSSPLQVAIKTLPELCSPQDELDFLMEALIISKFRHQN 511
Query: 802 VVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDEKLKSQPLSTKQKVALCTQVALG 861
+VR +GL A P ++LE + GD+K FLR S+ + PL + + L +A G
Sbjct: 512 IVRCVGLSLRATPRLILLELMSGGDMKSFLR--HSRPHLGQPSPLVMRDLLQLAQDIAQG 569
Query: 862 MEHLSNNRFVHKDLAARNCLVSA---QRQVKVSALGLSKDVYNSEYYHFR-QAWVPLRWM 917
+L N F+H+D+AARNCL+S R K+ G+++D+Y + YY +A +P++WM
Sbjct: 570 CHYLEENHFIHRDIAARNCLLSCAGPSRVAKIGDFGMARDIYRASYYRRGDRALLPVKWM 629
Query: 918 SPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQPEGCP 977
PEA LEG F++K+D W+FGVL+WE+F+ G MP+ G+ + EVL D G R+ P GCP
Sbjct: 630 PPEAFLEGIFTSKTDSWSFGVLLWEIFSLGYMPYPGRTNQEVL-DFVVGGGRMDPPRGCP 688
Query: 978 SKLYRLMQRCWALSPKDRPSFSEIASALGDSTVD 1011
+YR+M +CW P+ RPSF+ I L T D
Sbjct: 689 GPVYRIMTQCWQHEPELRPSFASILERLQYCTQD 722
>gi|4557665 insulin-like growth factor 1 receptor precursor [Homo
sapiens]
Length = 1367
Score = 197 bits (501), Expect = 4e-50
Identities = 100/278 (35%), Positives = 172/278 (61%), Gaps = 4/278 (1%)
Query: 731 DKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSL-QSKDEQQQLDFRR 789
D+ R + LG+ FG V+ A+G+ + ET V +K++ ++ +++++F
Sbjct: 990 DEWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLN 1049
Query: 790 ELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDEKLKS-QPLST 848
E + + N +VVRLLG+ + +P +++E + GDLK +LR + + E P S
Sbjct: 1050 EASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEMENNPVLAPPSL 1109
Query: 849 KQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEYYHFR 908
+ + + ++A GM +L+ N+FVH+DLAARNC+V+ VK+ G+++D+Y ++YY
Sbjct: 1110 SKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKG 1169
Query: 909 -QAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGK 967
+ +P+RWMSPE++ +G F+T SDVW+FGV++WE+ T E P+ G ++++VL + G
Sbjct: 1170 GKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEG- 1228
Query: 968 ARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASAL 1005
L +P+ CP L+ LM+ CW +PK RPSF EI S++
Sbjct: 1229 GLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSI 1266
>gi|21361306 neurotrophic tyrosine kinase, receptor, type 2 isoform a
precursor [Homo sapiens]
Length = 838
Score = 197 bits (500), Expect = 5e-50
Identities = 104/278 (37%), Positives = 162/278 (58%), Gaps = 8/278 (2%)
Query: 734 HFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQLDFRRELEM 793
H R ++ LG+ FG+VFLA+ L + LV VK+L+ + + DF RE E+
Sbjct: 548 HIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAEL 607
Query: 794 FGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDEKLKSQ-----PLST 848
L H ++V+ G+C E +P MV EY+ GDL +FLR + D L ++ L+
Sbjct: 608 LTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLR-AHGPDAVLMAEGNPPTELTQ 666
Query: 849 KQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEYYHF- 907
Q + + Q+A GM +L++ FVH+DLA RNCLV VK+ G+S+DVY+++YY
Sbjct: 667 SQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVG 726
Query: 908 RQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGK 967
+P+RWM PE+I+ F+T+SDVW+ GV++WE+FT+G+ P +++EV+ + G+
Sbjct: 727 GHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGR 786
Query: 968 ARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASAL 1005
L +P CP ++Y LM CW P R + I + L
Sbjct: 787 V-LQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLL 823
Score = 44.3 bits (103), Expect = 6e-04
Identities = 35/120 (29%), Positives = 53/120 (44%), Gaps = 10/120 (8%)
Query: 510 PQQCMEFDKEATVPCSATGREKPTIKWERAD-GSSLPEWVTDNAGTLHFARVTRDDAG-N 567
P +E K T+ CS G P + W+ + S + G+L ++ DD+G
Sbjct: 204 PNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQ 263
Query: 568 YTCIASNGPQGQIRAHVQLTV--AVFITFKVEPERTTVYQGHTALLQCEAQGDPKPLIQW 625
+C+A N G+ + V LTV A ITF P H + +G+PKP +QW
Sbjct: 264 ISCVAEN-LVGEDQDSVNLTVHFAPTITFLESPT-----SDHHWCIPFTVKGNPKPALQW 317
Score = 41.2 bits (95), Expect = 0.005
Identities = 45/176 (25%), Positives = 67/176 (38%), Gaps = 21/176 (11%)
Query: 423 LEEGKPGYLDCLTQATPKPTVVWYRNQMLISEDSRFEVFKNGTLRINSVEVYD-GTWYRC 481
+EEGK L C P P + W L+S+ G+LRI ++ D G C
Sbjct: 208 VEEGKSITLSCSVAGDPVPNMYWDVGN-LVSKHMNETSHTQGSLRITNISSDDSGKQISC 266
Query: 482 MSSTPAGSIEAQARVQVLEKLKFTPPPQPQQCMEFDKEATVPCSATGREKPTIKWERADG 541
++ G + + V F P + D +P + G KP ++W +G
Sbjct: 267 VAENLVGEDQDSVNLTV----HFAPTITFLESPTSDHHWCIPFTVKGNPKPALQW-FYNG 321
Query: 542 SSLPEWV-----------TDNAGTLHFARVTRDDAGNYTCIASN---GPQGQIRAH 583
+ L E T+ G L T + G+YT IA N + QI AH
Sbjct: 322 AILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAH 377
Score = 37.4 bits (85), Expect = 0.072
Identities = 36/172 (20%), Positives = 68/172 (39%), Gaps = 20/172 (11%)
Query: 45 QGRRALLRCEVEAPGPVHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSGTFQCVAR 104
+G+ L C V ++YW + + SL + CVA
Sbjct: 210 EGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVA- 268
Query: 105 DDVTGEEARSANASFNIKWIEAGPVV--LKHPASEAEIQPQTQVTLRCHIDGHPRPTYQW 162
+++ GE+ S N + + P + L+ P S+ + + G+P+P QW
Sbjct: 269 ENLVGEDQDSVNLT-----VHFAPTITFLESPTSDHHW------CIPFTVKGNPKPALQW 317
Query: 163 FRDGTPLSDGQ----SNHTVSSKERNLTLRPAGPEH--SGLYSCCAHSAFGQ 208
F +G L++ + H + E + L+ P H +G Y+ A + +G+
Sbjct: 318 FYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGK 369
Score = 33.5 bits (75), Expect = 1.0
Identities = 44/179 (24%), Positives = 66/179 (36%), Gaps = 18/179 (10%)
Query: 135 ASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSSKERNLTLRPAGPEH 194
A ++ +TL C + G P P W D L N T S + +L + +
Sbjct: 203 APNLTVEEGKSITLSCSVAGDPVPNMYW--DVGNLVSKHMNET-SHTQGSLRITNISSDD 259
Query: 195 SG-LYSCCAHSAFGQACSSQNFTLSIADESFARVVLAPQDVVVARYEEAMFHCQFSAQPP 253
SG SC A + G+ S N T+ FA + + + F P
Sbjct: 260 SGKQISCVAENLVGEDQDSVNLTV-----HFAPTITFLESPTSDHHWCIPF--TVKGNPK 312
Query: 254 PSLQWLFEDETPITNRSR----PPHLRRATVFANGSLLLTQVRPRNAGIYRCIGQGQRG 308
P+LQW + I N S+ H+ T + +G L L N G Y I + + G
Sbjct: 313 PALQWFYNG--AILNESKYICTKIHVTNHTEY-HGCLQLDNPTHMNNGDYTLIAKNEYG 368
>gi|119395738 insulin receptor isoform Short precursor [Homo sapiens]
Length = 1370
Score = 196 bits (499), Expect = 7e-50
Identities = 102/287 (35%), Positives = 175/287 (60%), Gaps = 4/287 (1%)
Query: 731 DKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSL-QSKDEQQQLDFRR 789
D+ R + + LG+ FG V+ A+ + +G AET V VK++ +S +++++F
Sbjct: 1002 DEWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLN 1061
Query: 790 ELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDEKLKSQPLSTK 849
E + +VVRLLG+ + +P +V+E + GDLK +LR + + E +P T
Sbjct: 1062 EASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTL 1121
Query: 850 QK-VALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEYYHFR 908
Q+ + + ++A GM +L+ +FVH+DLAARNC+V+ VK+ G+++D+Y ++YY
Sbjct: 1122 QEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKG 1181
Query: 909 -QAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGK 967
+ +P+RWM+PE++ +G F+T SD+W+FGV++WE+ + E P+ G ++++VL + G
Sbjct: 1182 GKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDG- 1240
Query: 968 ARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASALGDSTVDSKP 1014
L QP+ CP ++ LM+ CW +PK RP+F EI + L D S P
Sbjct: 1241 GYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLLKDDLHPSFP 1287
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.133 0.406
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 44,767,739
Number of Sequences: 37866
Number of extensions: 2277751
Number of successful extensions: 16129
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 606
Number of HSP's successfully gapped in prelim test: 511
Number of HSP's that attempted gapping in prelim test: 6296
Number of HSP's gapped (non-prelim): 4719
length of query: 1014
length of database: 18,247,518
effective HSP length: 112
effective length of query: 902
effective length of database: 14,006,526
effective search space: 12633886452
effective search space used: 12633886452
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.