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Search of human proteins with 227496504
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|227496504 multiple C2 domains, transmembrane 2 isoform 3
[Homo sapiens]
(306 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|227496504 multiple C2 domains, transmembrane 2 isoform 3 [Hom... 621 e-178
gi|227496489 multiple C2 domains, transmembrane 2 isoform 2 [Hom... 573 e-164
gi|227496440 multiple C2 domains, transmembrane 2 isoform 1 [Hom... 573 e-164
gi|50582996 multiple C2 domains, transmembrane 1 isoform S [Homo... 318 3e-87
gi|205361109 multiple C2 domains, transmembrane 1 isoform L [Hom... 318 3e-87
gi|194294523 intersectin 2 isoform 3 [Homo sapiens] 81 1e-15
gi|194294521 intersectin 2 isoform 1 [Homo sapiens] 81 1e-15
gi|103472031 family with sequence similarity 62 (C2 domain conta... 68 1e-11
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens] 67 2e-11
gi|14149680 extended synaptotagmin-like protein 1 [Homo sapiens] 67 3e-11
gi|122937514 unc-13 homolog C [Homo sapiens] 66 4e-11
gi|38570146 synaptotagmin VII [Homo sapiens] 66 4e-11
gi|21361472 neural precursor cell expressed, developmentally dow... 65 8e-11
gi|222352086 neural precursor cell expressed, developmentally do... 65 8e-11
gi|222352090 neural precursor cell expressed, developmentally do... 65 1e-10
gi|222352088 neural precursor cell expressed, developmentally do... 65 1e-10
gi|122937247 unc-13 homolog A [Homo sapiens] 64 1e-10
gi|45387945 family with sequence similarity 62 (C2 domain contai... 64 2e-10
gi|110611226 UNC13 (C. elegans)-like [Homo sapiens] 62 6e-10
gi|114520609 neural precursor cell expressed, developmentally do... 60 2e-09
gi|150170670 piccolo isoform 2 [Homo sapiens] 57 2e-08
gi|150378539 piccolo isoform 1 [Homo sapiens] 57 2e-08
gi|6005997 double C2-like domains, beta [Homo sapiens] 56 3e-08
gi|239743307 PREDICTED: similar to calcium-promoted Ras inactiva... 56 5e-08
gi|239508990 PREDICTED: similar to calcium-promoted Ras inactiva... 56 5e-08
gi|121114292 RAS p21 protein activator 4 isoform 2 [Homo sapiens] 56 5e-08
gi|121114294 RAS p21 protein activator 4 isoform 1 [Homo sapiens] 56 5e-08
gi|47078261 double C2-like domains, alpha [Homo sapiens] 55 1e-07
gi|211059429 synaptotagmin II [Homo sapiens] 54 1e-07
gi|31543670 synaptotagmin II [Homo sapiens] 54 1e-07
>gi|227496504 multiple C2 domains, transmembrane 2 isoform 3 [Homo
sapiens]
Length = 306
Score = 621 bits (1601), Expect = e-178
Identities = 306/306 (100%), Positives = 306/306 (100%)
Query: 1 MGILDIEVWGKDNKKHEERLGTCKVDISALPLKQANCLELPLDSCLGALLMLVTLTPCAG 60
MGILDIEVWGKDNKKHEERLGTCKVDISALPLKQANCLELPLDSCLGALLMLVTLTPCAG
Sbjct: 1 MGILDIEVWGKDNKKHEERLGTCKVDISALPLKQANCLELPLDSCLGALLMLVTLTPCAG 60
Query: 61 VSVSDLCVCPLADLSERKQITQRYCLQNSLKDVKDVGILQVKVLKAADLLAADFSGKSDP 120
VSVSDLCVCPLADLSERKQITQRYCLQNSLKDVKDVGILQVKVLKAADLLAADFSGKSDP
Sbjct: 61 VSVSDLCVCPLADLSERKQITQRYCLQNSLKDVKDVGILQVKVLKAADLLAADFSGKSDP 120
Query: 121 FCLLELGNDRLQTHTVYKNLNPEWNKVFTFPIKDIHDVLEVTVFDEDGDKPPDFLGKVAI 180
FCLLELGNDRLQTHTVYKNLNPEWNKVFTFPIKDIHDVLEVTVFDEDGDKPPDFLGKVAI
Sbjct: 121 FCLLELGNDRLQTHTVYKNLNPEWNKVFTFPIKDIHDVLEVTVFDEDGDKPPDFLGKVAI 180
Query: 181 PLLSIRDGQPNCYVLKNKDLEQAFKGVIYLEMDLIYNPVKASIRTFTPREKRFVEDSRKL 240
PLLSIRDGQPNCYVLKNKDLEQAFKGVIYLEMDLIYNPVKASIRTFTPREKRFVEDSRKL
Sbjct: 181 PLLSIRDGQPNCYVLKNKDLEQAFKGVIYLEMDLIYNPVKASIRTFTPREKRFVEDSRKL 240
Query: 241 SKKILSRDVDRVKRITMAIWNTMQFLKSCFQWESTLRSTIAFAHRKEEPPLSMKCTLFSG 300
SKKILSRDVDRVKRITMAIWNTMQFLKSCFQWESTLRSTIAFAHRKEEPPLSMKCTLFSG
Sbjct: 241 SKKILSRDVDRVKRITMAIWNTMQFLKSCFQWESTLRSTIAFAHRKEEPPLSMKCTLFSG 300
Query: 301 DIGPSL 306
DIGPSL
Sbjct: 301 DIGPSL 306
>gi|227496489 multiple C2 domains, transmembrane 2 isoform 2 [Homo
sapiens]
Length = 823
Score = 573 bits (1478), Expect = e-164
Identities = 283/288 (98%), Positives = 286/288 (99%)
Query: 1 MGILDIEVWGKDNKKHEERLGTCKVDISALPLKQANCLELPLDSCLGALLMLVTLTPCAG 60
MGILDIEVWGKDNKKHEERLGTCKVDISALPLKQANCLELPLDSCLGALLMLVTLTPCAG
Sbjct: 413 MGILDIEVWGKDNKKHEERLGTCKVDISALPLKQANCLELPLDSCLGALLMLVTLTPCAG 472
Query: 61 VSVSDLCVCPLADLSERKQITQRYCLQNSLKDVKDVGILQVKVLKAADLLAADFSGKSDP 120
VSVSDLCVCPLADLSERKQITQRYCLQNSLKDVKDVGILQVKVLKAADLLAADFSGKSDP
Sbjct: 473 VSVSDLCVCPLADLSERKQITQRYCLQNSLKDVKDVGILQVKVLKAADLLAADFSGKSDP 532
Query: 121 FCLLELGNDRLQTHTVYKNLNPEWNKVFTFPIKDIHDVLEVTVFDEDGDKPPDFLGKVAI 180
FCLLELGNDRLQTHTVYKNLNPEWNKVFTFPIKDIHDVLEVTVFDEDGDKPPDFLGKVAI
Sbjct: 533 FCLLELGNDRLQTHTVYKNLNPEWNKVFTFPIKDIHDVLEVTVFDEDGDKPPDFLGKVAI 592
Query: 181 PLLSIRDGQPNCYVLKNKDLEQAFKGVIYLEMDLIYNPVKASIRTFTPREKRFVEDSRKL 240
PLLSIRDGQPNCYVLKNKDLEQAFKGVIYLEMDLIYNPVKASIRTFTPREKRFVEDSRKL
Sbjct: 593 PLLSIRDGQPNCYVLKNKDLEQAFKGVIYLEMDLIYNPVKASIRTFTPREKRFVEDSRKL 652
Query: 241 SKKILSRDVDRVKRITMAIWNTMQFLKSCFQWESTLRSTIAFAHRKEE 288
SKKILSRDVDRVKRITMAIWNTMQFLKSCFQWESTLRSTIAFA +++
Sbjct: 653 SKKILSRDVDRVKRITMAIWNTMQFLKSCFQWESTLRSTIAFAESEKK 700
Score = 58.5 bits (140), Expect = 7e-09
Identities = 37/122 (30%), Positives = 64/122 (52%), Gaps = 6/122 (4%)
Query: 98 ILQVKVLKAADLLAADFSGKSDPFCLLELGNDRL-QTHTVYKNLNPEWNKVFTFPIKDIH 156
+L + + + +L+ D G SDP+ +L L ++ +YKNLNP W+++ PI+ +
Sbjct: 195 LLTIHLKEGRNLVVRDRCGTSDPYVKFKLNGKTLYKSKVIYKNLNPVWDEIVVLPIQSLD 254
Query: 157 DVLEVTVFDEDGDKPPDFLGKVAIPLLSIRDGQPNCYVLKNKD---LEQAFKGVIYLEMD 213
L V V+D D DF+G + L + + ++LK +D LE GVI L ++
Sbjct: 255 QKLRVKVYDRD-LTTSDFMGSAFVILSDLELNRTTEHILKLEDPNSLEDDM-GVIVLNLN 312
Query: 214 LI 215
L+
Sbjct: 313 LV 314
Score = 45.8 bits (107), Expect = 5e-05
Identities = 26/100 (26%), Positives = 52/100 (52%), Gaps = 4/100 (4%)
Query: 97 GILQVKVLKAADLLAADFSGKSDPFCLLELGNDRLQTHTVYKNLNPEWNKVFTFP-IKDI 155
GI+ + +L+ ++ + + F L+LG+ R ++ T+ K+ NP+W + F F D
Sbjct: 356 GIISITLLEGKNVSGGSMT---EMFVQLKLGDQRYKSKTLCKSANPQWQEQFDFHYFSDR 412
Query: 156 HDVLEVTVFDEDGDKPPDFLGKVAIPLLSIRDGQPNCYVL 195
+L++ V+ +D K + LG + + ++ Q NC L
Sbjct: 413 MGILDIEVWGKDNKKHEERLGTCKVDISALPLKQANCLEL 452
>gi|227496440 multiple C2 domains, transmembrane 2 isoform 1 [Homo
sapiens]
Length = 878
Score = 573 bits (1476), Expect = e-164
Identities = 283/283 (100%), Positives = 283/283 (100%)
Query: 1 MGILDIEVWGKDNKKHEERLGTCKVDISALPLKQANCLELPLDSCLGALLMLVTLTPCAG 60
MGILDIEVWGKDNKKHEERLGTCKVDISALPLKQANCLELPLDSCLGALLMLVTLTPCAG
Sbjct: 413 MGILDIEVWGKDNKKHEERLGTCKVDISALPLKQANCLELPLDSCLGALLMLVTLTPCAG 472
Query: 61 VSVSDLCVCPLADLSERKQITQRYCLQNSLKDVKDVGILQVKVLKAADLLAADFSGKSDP 120
VSVSDLCVCPLADLSERKQITQRYCLQNSLKDVKDVGILQVKVLKAADLLAADFSGKSDP
Sbjct: 473 VSVSDLCVCPLADLSERKQITQRYCLQNSLKDVKDVGILQVKVLKAADLLAADFSGKSDP 532
Query: 121 FCLLELGNDRLQTHTVYKNLNPEWNKVFTFPIKDIHDVLEVTVFDEDGDKPPDFLGKVAI 180
FCLLELGNDRLQTHTVYKNLNPEWNKVFTFPIKDIHDVLEVTVFDEDGDKPPDFLGKVAI
Sbjct: 533 FCLLELGNDRLQTHTVYKNLNPEWNKVFTFPIKDIHDVLEVTVFDEDGDKPPDFLGKVAI 592
Query: 181 PLLSIRDGQPNCYVLKNKDLEQAFKGVIYLEMDLIYNPVKASIRTFTPREKRFVEDSRKL 240
PLLSIRDGQPNCYVLKNKDLEQAFKGVIYLEMDLIYNPVKASIRTFTPREKRFVEDSRKL
Sbjct: 593 PLLSIRDGQPNCYVLKNKDLEQAFKGVIYLEMDLIYNPVKASIRTFTPREKRFVEDSRKL 652
Query: 241 SKKILSRDVDRVKRITMAIWNTMQFLKSCFQWESTLRSTIAFA 283
SKKILSRDVDRVKRITMAIWNTMQFLKSCFQWESTLRSTIAFA
Sbjct: 653 SKKILSRDVDRVKRITMAIWNTMQFLKSCFQWESTLRSTIAFA 695
Score = 58.5 bits (140), Expect = 7e-09
Identities = 37/122 (30%), Positives = 64/122 (52%), Gaps = 6/122 (4%)
Query: 98 ILQVKVLKAADLLAADFSGKSDPFCLLELGNDRL-QTHTVYKNLNPEWNKVFTFPIKDIH 156
+L + + + +L+ D G SDP+ +L L ++ +YKNLNP W+++ PI+ +
Sbjct: 195 LLTIHLKEGRNLVVRDRCGTSDPYVKFKLNGKTLYKSKVIYKNLNPVWDEIVVLPIQSLD 254
Query: 157 DVLEVTVFDEDGDKPPDFLGKVAIPLLSIRDGQPNCYVLKNKD---LEQAFKGVIYLEMD 213
L V V+D D DF+G + L + + ++LK +D LE GVI L ++
Sbjct: 255 QKLRVKVYDRD-LTTSDFMGSAFVILSDLELNRTTEHILKLEDPNSLEDDM-GVIVLNLN 312
Query: 214 LI 215
L+
Sbjct: 313 LV 314
Score = 45.8 bits (107), Expect = 5e-05
Identities = 26/100 (26%), Positives = 52/100 (52%), Gaps = 4/100 (4%)
Query: 97 GILQVKVLKAADLLAADFSGKSDPFCLLELGNDRLQTHTVYKNLNPEWNKVFTFP-IKDI 155
GI+ + +L+ ++ + + F L+LG+ R ++ T+ K+ NP+W + F F D
Sbjct: 356 GIISITLLEGKNVSGGSMT---EMFVQLKLGDQRYKSKTLCKSANPQWQEQFDFHYFSDR 412
Query: 156 HDVLEVTVFDEDGDKPPDFLGKVAIPLLSIRDGQPNCYVL 195
+L++ V+ +D K + LG + + ++ Q NC L
Sbjct: 413 MGILDIEVWGKDNKKHEERLGTCKVDISALPLKQANCLEL 452
>gi|50582996 multiple C2 domains, transmembrane 1 isoform S [Homo
sapiens]
Length = 778
Score = 318 bits (816), Expect = 3e-87
Identities = 159/281 (56%), Positives = 207/281 (73%)
Query: 2 GILDIEVWGKDNKKHEERLGTCKVDISALPLKQANCLELPLDSCLGALLMLVTLTPCAGV 61
G++DI W KD K ++ +G C+VD+SAL +Q + LEL L+ G L++LVTLT A V
Sbjct: 310 GVIDITAWDKDAGKRDDFIGRCQVDLSALSREQTHKLELQLEEGEGHLVLLVTLTASATV 369
Query: 62 SVSDLCVCPLADLSERKQITQRYCLQNSLKDVKDVGILQVKVLKAADLLAADFSGKSDPF 121
S+SDL V L D ER++I +RY ++KDVG LQVKV++A L+AAD +GKSDPF
Sbjct: 370 SISDLSVNSLEDQKEREEILKRYSPLRIFHNLKDVGFLQVKVIRAEGLMAADVTGKSDPF 429
Query: 122 CLLELGNDRLQTHTVYKNLNPEWNKVFTFPIKDIHDVLEVTVFDEDGDKPPDFLGKVAIP 181
C++EL NDRL THTVYKNLNPEWNKVFTF IKDIH VLEVTV+DED D+ DFLGKVAIP
Sbjct: 430 CVVELNNDRLLTHTVYKNLNPEWNKVFTFNIKDIHSVLEVTVYDEDRDRSADFLGKVAIP 489
Query: 182 LLSIRDGQPNCYVLKNKDLEQAFKGVIYLEMDLIYNPVKASIRTFTPREKRFVEDSRKLS 241
LLSI++G+ YVLKNK L KGVIYLE+D+I+N VKAS+RT P+E++++E+ +LS
Sbjct: 490 LLSIQNGEQKAYVLKNKQLTGPTKGVIYLEIDVIFNAVKASLRTLIPKEQKYIEEENRLS 549
Query: 242 KKILSRDVDRVKRITMAIWNTMQFLKSCFQWESTLRSTIAF 282
K++L R+ R+KR M + N ++ SCF W+S RS AF
Sbjct: 550 KQLLLRNFIRMKRCVMVLVNAAYYVNSCFDWDSPPRSLAAF 590
Score = 62.8 bits (151), Expect = 4e-10
Identities = 28/90 (31%), Positives = 55/90 (61%), Gaps = 1/90 (1%)
Query: 97 GILQVKVLKAADLLAADFSGKSDPFCLLELGNDRLQTHTVYKNLNPEWNKVFTFPI-KDI 155
GI+ + +++ DL A D +G SDP+ LG+ + ++ + K LNP+W + F F + ++
Sbjct: 249 GIVSITLIEGRDLKAMDSNGLSDPYVKFRLGHQKYKSKIMPKTLNPQWREQFDFHLYEER 308
Query: 156 HDVLEVTVFDEDGDKPPDFLGKVAIPLLSI 185
V+++T +D+D K DF+G+ + L ++
Sbjct: 309 GGVIDITAWDKDAGKRDDFIGRCQVDLSAL 338
Score = 55.8 bits (133), Expect = 5e-08
Identities = 45/189 (23%), Positives = 80/189 (42%), Gaps = 7/189 (3%)
Query: 78 KQITQRYCLQNSLKDVKDVGILQVKVL--KAADLLAADFSGKSDPFCLLELGNDRL-QTH 134
K+I N+ + D G+ Q+ + + L A D G SDP+ ++G + ++
Sbjct: 19 KKIINTAGTSNAEVPLADPGMYQLDITLRRGQSLAARDRGGTSDPYVKFKIGGKEVFRSK 78
Query: 135 TVYKNLNPEWNKVFTFPIKDIHDVLEVTVFDEDGDKPPDFLGKVAIPLLSIRDGQPNCYV 194
++KNLNP W + + + + L + VFD D DF+G + L + +P
Sbjct: 79 IIHKNLNPVWEEKACILVDHLREPLYIKVFDYDFGLQDDFMGSAFLDLTQLELNRPTDVT 138
Query: 195 LKNKDLEQAFKGVIYLEMDLIYNPVKASIRTFTP-REKRFVEDSRKLSKKILSRDVDRVK 253
L KD + + + +I P + R T K + S++LS+ + VK
Sbjct: 139 LTLKDPHYPDHDLGIILLSVILTPKEGESRDVTMLMRKSWKRSSKELSENEVVGSYFSVK 198
Query: 254 RITMAIWNT 262
+ W T
Sbjct: 199 SL---FWRT 204
>gi|205361109 multiple C2 domains, transmembrane 1 isoform L [Homo
sapiens]
Length = 999
Score = 318 bits (816), Expect = 3e-87
Identities = 159/281 (56%), Positives = 207/281 (73%)
Query: 2 GILDIEVWGKDNKKHEERLGTCKVDISALPLKQANCLELPLDSCLGALLMLVTLTPCAGV 61
G++DI W KD K ++ +G C+VD+SAL +Q + LEL L+ G L++LVTLT A V
Sbjct: 531 GVIDITAWDKDAGKRDDFIGRCQVDLSALSREQTHKLELQLEEGEGHLVLLVTLTASATV 590
Query: 62 SVSDLCVCPLADLSERKQITQRYCLQNSLKDVKDVGILQVKVLKAADLLAADFSGKSDPF 121
S+SDL V L D ER++I +RY ++KDVG LQVKV++A L+AAD +GKSDPF
Sbjct: 591 SISDLSVNSLEDQKEREEILKRYSPLRIFHNLKDVGFLQVKVIRAEGLMAADVTGKSDPF 650
Query: 122 CLLELGNDRLQTHTVYKNLNPEWNKVFTFPIKDIHDVLEVTVFDEDGDKPPDFLGKVAIP 181
C++EL NDRL THTVYKNLNPEWNKVFTF IKDIH VLEVTV+DED D+ DFLGKVAIP
Sbjct: 651 CVVELNNDRLLTHTVYKNLNPEWNKVFTFNIKDIHSVLEVTVYDEDRDRSADFLGKVAIP 710
Query: 182 LLSIRDGQPNCYVLKNKDLEQAFKGVIYLEMDLIYNPVKASIRTFTPREKRFVEDSRKLS 241
LLSI++G+ YVLKNK L KGVIYLE+D+I+N VKAS+RT P+E++++E+ +LS
Sbjct: 711 LLSIQNGEQKAYVLKNKQLTGPTKGVIYLEIDVIFNAVKASLRTLIPKEQKYIEEENRLS 770
Query: 242 KKILSRDVDRVKRITMAIWNTMQFLKSCFQWESTLRSTIAF 282
K++L R+ R+KR M + N ++ SCF W+S RS AF
Sbjct: 771 KQLLLRNFIRMKRCVMVLVNAAYYVNSCFDWDSPPRSLAAF 811
Score = 62.8 bits (151), Expect = 4e-10
Identities = 28/90 (31%), Positives = 55/90 (61%), Gaps = 1/90 (1%)
Query: 97 GILQVKVLKAADLLAADFSGKSDPFCLLELGNDRLQTHTVYKNLNPEWNKVFTFPI-KDI 155
GI+ + +++ DL A D +G SDP+ LG+ + ++ + K LNP+W + F F + ++
Sbjct: 470 GIVSITLIEGRDLKAMDSNGLSDPYVKFRLGHQKYKSKIMPKTLNPQWREQFDFHLYEER 529
Query: 156 HDVLEVTVFDEDGDKPPDFLGKVAIPLLSI 185
V+++T +D+D K DF+G+ + L ++
Sbjct: 530 GGVIDITAWDKDAGKRDDFIGRCQVDLSAL 559
Score = 55.1 bits (131), Expect = 8e-08
Identities = 40/166 (24%), Positives = 71/166 (42%), Gaps = 5/166 (3%)
Query: 99 LQVKVLKAADLLAADFSGKSDPFCLLELGNDRL-QTHTVYKNLNPEWNKVFTFPIKDIHD 157
L + + + L A D G SDP+ ++G + ++ ++KNLNP W + + + +
Sbjct: 263 LDITLRRGQSLAARDRGGTSDPYVKFKIGGKEVFRSKIIHKNLNPVWEEKACILVDHLRE 322
Query: 158 VLEVTVFDEDGDKPPDFLGKVAIPLLSIRDGQPNCYVLKNKDLEQAFKGVIYLEMDLIYN 217
L + VFD D DF+G + L + +P L KD + + + +I
Sbjct: 323 PLYIKVFDYDFGLQDDFMGSAFLDLTQLELNRPTDVTLTLKDPHYPDHDLGIILLSVILT 382
Query: 218 PVKASIRTFTP-REKRFVEDSRKLSKKILSRDVDRVKRITMAIWNT 262
P + R T K + S++LS+ + VK + W T
Sbjct: 383 PKEGESRDVTMLMRKSWKRSSKELSENEVVGSYFSVKSL---FWRT 425
>gi|194294523 intersectin 2 isoform 3 [Homo sapiens]
Length = 1670
Score = 80.9 bits (198), Expect = 1e-15
Identities = 45/116 (38%), Positives = 68/116 (58%), Gaps = 3/116 (2%)
Query: 75 SERKQITQRYCLQNSLKDVKDVGILQVKVLKAADLLAADFSGKSDPFCLLELGNDRLQTH 134
+E+K+ + Y Q + +G L V V++A +L A +GKS+P+C + +G+ T
Sbjct: 1522 TEKKKREKAY--QARSQKTSGIGRLMVHVIEATELKACKPNGKSNPYCEISMGSQSYTTR 1579
Query: 135 TVYKNLNPEWNKVFTFPIKDIH-DVLEVTVFDEDGDKPPDFLGKVAIPLLSIRDGQ 189
T+ LNP+WN F IKD++ DVL +T+FD D P DFLG+ IP+ IR Q
Sbjct: 1580 TIQDTLNPKWNFNCQFFIKDLYQDVLCLTLFDRDQFSPDDFLGRTEIPVAKIRTEQ 1635
>gi|194294521 intersectin 2 isoform 1 [Homo sapiens]
Length = 1697
Score = 80.9 bits (198), Expect = 1e-15
Identities = 45/116 (38%), Positives = 68/116 (58%), Gaps = 3/116 (2%)
Query: 75 SERKQITQRYCLQNSLKDVKDVGILQVKVLKAADLLAADFSGKSDPFCLLELGNDRLQTH 134
+E+K+ + Y Q + +G L V V++A +L A +GKS+P+C + +G+ T
Sbjct: 1549 TEKKKREKAY--QARSQKTSGIGRLMVHVIEATELKACKPNGKSNPYCEISMGSQSYTTR 1606
Query: 135 TVYKNLNPEWNKVFTFPIKDIH-DVLEVTVFDEDGDKPPDFLGKVAIPLLSIRDGQ 189
T+ LNP+WN F IKD++ DVL +T+FD D P DFLG+ IP+ IR Q
Sbjct: 1607 TIQDTLNPKWNFNCQFFIKDLYQDVLCLTLFDRDQFSPDDFLGRTEIPVAKIRTEQ 1662
>gi|103472031 family with sequence similarity 62 (C2 domain
containing), member C [Homo sapiens]
Length = 886
Score = 67.8 bits (164), Expect = 1e-11
Identities = 36/91 (39%), Positives = 56/91 (61%), Gaps = 6/91 (6%)
Query: 97 GILQVKVLKAADLLAAD----FSGKSDPFCLLELGNDRLQTHTVYKNLNPEWNKVFTFPI 152
G+++V +L+A L D GKSDP+ + +G ++ T+Y+NLNP WN+VF F +
Sbjct: 306 GVIRVHLLEAEQLAQKDNFLGLRGKSDPYAKVSIGLQHFRSRTIYRNLNPTWNEVFEFMV 365
Query: 153 KDI-HDVLEVTVFDEDGDKPPDFLGKVAIPL 182
++ LEV ++DED D+ DFLG + I L
Sbjct: 366 YEVPGQDLEVDLYDEDTDR-DDFLGSLQICL 395
Score = 28.9 bits (63), Expect = 6.0
Identities = 24/85 (28%), Positives = 41/85 (48%), Gaps = 15/85 (17%)
Query: 124 LELGNDRLQTHTVYKNLNPEWNKVFTFPIKDI-HDVLEVTVFDEDGDKPPDFLGKVAIPL 182
L +G + T N +P W++VF+F + ++ + L + V D+D + LG + +PL
Sbjct: 491 LSVGKKTHTSKTCPHNKDPVWSQVFSFFVHNVATERLHLKVLDDDQECA---LGMLEVPL 547
Query: 183 LSIRDGQPNCYVLKNKD--LEQAFK 205
C +L D LEQ F+
Sbjct: 548 ---------CQILPYADLTLEQRFQ 563
>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
Length = 1721
Score = 67.4 bits (163), Expect = 2e-11
Identities = 45/142 (31%), Positives = 75/142 (52%), Gaps = 4/142 (2%)
Query: 75 SERKQITQRYCLQNSLKDVKDVGILQVKVLKAADLLAADFSGKSDPFCLLELGNDRLQTH 134
+E+K+ + Y +++ + +G L V V++ +L GKS+P+C + +G+ T
Sbjct: 1576 TEKKKREKAYLVRS--QRATGIGRLMVNVVEGIELKPCRSHGKSNPYCEVTMGSQCHITK 1633
Query: 135 TVYKNLNPEWNKVFTFPIKDI-HDVLEVTVFDEDGDKPPDFLGKVAIPLLSIRDGQ-PNC 192
T+ LNP+WN F I+D+ +VL +TVF+ D P DFLG+ I + I+ Q
Sbjct: 1634 TIQDTLNPKWNSNCQFFIRDLEQEVLCITVFERDQFSPDDFLGRTEIRVADIKKDQGSKG 1693
Query: 193 YVLKNKDLEQAFKGVIYLEMDL 214
V K L + G I + +DL
Sbjct: 1694 PVTKCLLLHEVPTGEIVVRLDL 1715
>gi|14149680 extended synaptotagmin-like protein 1 [Homo sapiens]
Length = 1104
Score = 66.6 bits (161), Expect = 3e-11
Identities = 38/95 (40%), Positives = 57/95 (60%), Gaps = 8/95 (8%)
Query: 98 ILQVKVLKAADLLAAD------FSGKSDPFCLLELGNDRLQTHTVYKNLNPEWNKVFTFP 151
+L++ VL+A DL+A D GKSDP+ L+L ++H V ++LNP WN+VF
Sbjct: 648 VLRIHVLEAQDLIAKDRFLGGLVKGKSDPYVKLKLAGRSFRSHVVREDLNPRWNEVFEVI 707
Query: 152 IKDI-HDVLEVTVFDEDGDKPPDFLGKVAIPLLSI 185
+ + LEV VFD+D DK DFLG+ + L ++
Sbjct: 708 VTSVPGQELEVEVFDKDLDK-DDFLGRCKVRLTTV 741
Score = 55.5 bits (132), Expect = 6e-08
Identities = 30/91 (32%), Positives = 51/91 (56%), Gaps = 8/91 (8%)
Query: 97 GILQVKVLKAADLLAAD------FSGKSDPFCLLELGNDRLQTHTVYKNLNPEWNKVFTF 150
GI+++ +L A L + D GKSDP+ L+ LG + + + LNP+W + +
Sbjct: 329 GIIRIHLLAARGLSSKDKYVKGLIEGKSDPYALVRLGTQTFCSRVIDEELNPQWGETYEV 388
Query: 151 PIKDI-HDVLEVTVFDEDGDKPPDFLGKVAI 180
+ ++ +EV VFD+D DK DFLG++ +
Sbjct: 389 MVHEVPGQEIEVEVFDKDPDK-DDFLGRMKL 418
Score = 36.2 bits (82), Expect = 0.037
Identities = 45/182 (24%), Positives = 79/182 (43%), Gaps = 21/182 (11%)
Query: 4 LDIEVWGKDNKKHEERLGTCKVDISALPLKQANCLE--LPLDSCLGALLMLVTLTPCAGV 61
+++EV+ KD K ++ LG K+D+ + QA+ L+ PL G + + +
Sbjct: 398 IEVEVFDKDPDK-DDFLGRMKLDVGKV--LQASVLDDWFPLQGGQGQVHLRLEWLSL--- 451
Query: 62 SVSDLCVCPLADLSERKQITQRYCLQNSLKDVKDVGILQVKVLKAADLLAADFSGKSDPF 121
L+D + +Q+ Q +S D IL V + +A DL + + +P
Sbjct: 452 ---------LSDAEKLEQVLQWNWGVSSRPDPPSAAILVVYLDRAQDLPLKKGNKEPNPM 502
Query: 122 CLLELGNDRLQTHTVYKNLNPEWNKVFTFPIKDIH-DVLEVTVFDEDGDKPPDFLGKVAI 180
L + + ++ VY P W + F F ++D L+V V D D LG + +
Sbjct: 503 VQLSIQDVTQESKAVYSTNCPVWEEAFRFFLQDPQSQELDVQVKD---DSRALTLGALTL 559
Query: 181 PL 182
PL
Sbjct: 560 PL 561
>gi|122937514 unc-13 homolog C [Homo sapiens]
Length = 2214
Score = 65.9 bits (159), Expect = 4e-11
Identities = 36/127 (28%), Positives = 68/127 (53%), Gaps = 11/127 (8%)
Query: 99 LQVKVLKAADLLAADFSGKSDPFCLLELGNDRLQTHTVYKNLNPEWNKVFTFPIKDIHDV 158
+ + V+ A L A D +G SDP+ +++G ++ +T T++ NLNP W++ F F + D
Sbjct: 1222 ITITVVSAQGLQAKDKTGSSDPYVTVQVGKNKRRTKTIFGNLNPVWDEKFYFECHNSTDR 1281
Query: 159 LEVTVFDEDGD-----------KPPDFLGKVAIPLLSIRDGQPNCYVLKNKDLEQAFKGV 207
++V V+DED D + DFLG+ + + ++ Y L+ + + A G
Sbjct: 1282 IKVRVWDEDDDIKSRVKQHFKKESDDFLGQTIVEVRTLSGEMDVWYNLEKRTDKSAVSGA 1341
Query: 208 IYLEMDL 214
I L++++
Sbjct: 1342 IRLKINV 1348
>gi|38570146 synaptotagmin VII [Homo sapiens]
Length = 403
Score = 65.9 bits (159), Expect = 4e-11
Identities = 48/132 (36%), Positives = 64/132 (48%), Gaps = 7/132 (5%)
Query: 99 LQVKVLKAADLLAADFSGKSDPFCLLELGND---RLQTHTVYKNLNPEWNKVFTFP---- 151
L VK++KA +L A DFSG SDPF + L D +L+T KNLNP WN+ F F
Sbjct: 152 LTVKIMKAQELPAKDFSGTSDPFVKIYLLPDKKHKLETKVKRKNLNPHWNETFLFEGFPY 211
Query: 152 IKDIHDVLEVTVFDEDGDKPPDFLGKVAIPLLSIRDGQPNCYVLKNKDLEQAFKGVIYLE 211
K + +L + V D D D +G+V+IPL + Q + K L
Sbjct: 212 EKVVQRILYLQVLDYDRFSRNDPIGEVSIPLNKVDLTQMQTFWKDLKPCSDGSGSRGELL 271
Query: 212 MDLIYNPVKASI 223
+ L YNP SI
Sbjct: 272 LSLCYNPSANSI 283
Score = 43.9 bits (102), Expect = 2e-04
Identities = 29/86 (33%), Positives = 46/86 (53%), Gaps = 8/86 (9%)
Query: 101 VKVLKAADLLAADFSGKSDPFCLLEL-----GNDRLQTHTVYKNLNPEWNKVFTFPI--- 152
V ++KA +L A D G SDP+ + L ++ +T T+ +NLNP +N+ F F I
Sbjct: 285 VNIIKARNLKAMDIGGTSDPYVKVWLMYKDKRVEKKKTVTMKRNLNPIFNESFAFDIPTE 344
Query: 153 KDIHDVLEVTVFDEDGDKPPDFLGKV 178
K + +TV D+D D +GK+
Sbjct: 345 KLRETTIIITVMDKDKLSRNDVIGKI 370
>gi|21361472 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 3 [Homo sapiens]
Length = 955
Score = 65.1 bits (157), Expect = 8e-11
Identities = 46/137 (33%), Positives = 67/137 (48%), Gaps = 15/137 (10%)
Query: 91 KDVKDVGILQVKVLKAADLLAADFSGKSDPFCLLEL----GNDRL---QTHTVYKNLNPE 143
+D + IL+VKV+ DL D G SDP+ L L N L QT T+ K LNP+
Sbjct: 14 EDEGESRILRVKVVSGIDLAKKDIFGASDPYVKLSLYVADENRELALVQTKTIKKTLNPK 73
Query: 144 WNKVFTFPIKDIHDVLEVTVFDEDGDKPPDFLGKVAIPLLSIRDGQPNC--------YVL 195
WN+ F F + + L VFDE+ DFLG+V +PL + P ++L
Sbjct: 74 WNEEFYFRVNPSNHRLLFEVFDENRLTRDDFLGQVDVPLSHLPTEDPTMERPYTFKDFLL 133
Query: 196 KNKDLEQAFKGVIYLEM 212
+ + + KG + L+M
Sbjct: 134 RPRSHKSRVKGFLRLKM 150
>gi|222352086 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 1 [Homo sapiens]
Length = 975
Score = 65.1 bits (157), Expect = 8e-11
Identities = 46/137 (33%), Positives = 67/137 (48%), Gaps = 15/137 (10%)
Query: 91 KDVKDVGILQVKVLKAADLLAADFSGKSDPFCLLEL----GNDRL---QTHTVYKNLNPE 143
+D + IL+VKV+ DL D G SDP+ L L N L QT T+ K LNP+
Sbjct: 14 EDEGESRILRVKVVSGIDLAKKDIFGASDPYVKLSLYVADENRELALVQTKTIKKTLNPK 73
Query: 144 WNKVFTFPIKDIHDVLEVTVFDEDGDKPPDFLGKVAIPLLSIRDGQPNC--------YVL 195
WN+ F F + + L VFDE+ DFLG+V +PL + P ++L
Sbjct: 74 WNEEFYFRVNPSNHRLLFEVFDENRLTRDDFLGQVDVPLSHLPTEDPTMERPYTFKDFLL 133
Query: 196 KNKDLEQAFKGVIYLEM 212
+ + + KG + L+M
Sbjct: 134 RPRSHKSRVKGFLRLKM 150
>gi|222352090 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 5 [Homo sapiens]
Length = 947
Score = 64.7 bits (156), Expect = 1e-10
Identities = 45/130 (34%), Positives = 64/130 (49%), Gaps = 15/130 (11%)
Query: 98 ILQVKVLKAADLLAADFSGKSDPFCLLEL----GNDRL---QTHTVYKNLNPEWNKVFTF 150
IL+VKV+ DL D G SDP+ L L N L QT T+ K LNP+WN+ F F
Sbjct: 13 ILRVKVVSGIDLAKKDIFGASDPYVKLSLYVADENRELALVQTKTIKKTLNPKWNEEFYF 72
Query: 151 PIKDIHDVLEVTVFDEDGDKPPDFLGKVAIPLLSIRDGQPNC--------YVLKNKDLEQ 202
+ + L VFDE+ DFLG+V +PL + P ++L+ + +
Sbjct: 73 RVNPSNHRLLFEVFDENRLTRDDFLGQVDVPLSHLPTEDPTMERPYTFKDFLLRPRSHKS 132
Query: 203 AFKGVIYLEM 212
KG + L+M
Sbjct: 133 RVKGFLRLKM 142
>gi|222352088 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 4 [Homo sapiens]
Length = 967
Score = 64.7 bits (156), Expect = 1e-10
Identities = 45/130 (34%), Positives = 64/130 (49%), Gaps = 15/130 (11%)
Query: 98 ILQVKVLKAADLLAADFSGKSDPFCLLEL----GNDRL---QTHTVYKNLNPEWNKVFTF 150
IL+VKV+ DL D G SDP+ L L N L QT T+ K LNP+WN+ F F
Sbjct: 13 ILRVKVVSGIDLAKKDIFGASDPYVKLSLYVADENRELALVQTKTIKKTLNPKWNEEFYF 72
Query: 151 PIKDIHDVLEVTVFDEDGDKPPDFLGKVAIPLLSIRDGQPNC--------YVLKNKDLEQ 202
+ + L VFDE+ DFLG+V +PL + P ++L+ + +
Sbjct: 73 RVNPSNHRLLFEVFDENRLTRDDFLGQVDVPLSHLPTEDPTMERPYTFKDFLLRPRSHKS 132
Query: 203 AFKGVIYLEM 212
KG + L+M
Sbjct: 133 RVKGFLRLKM 142
>gi|122937247 unc-13 homolog A [Homo sapiens]
Length = 1791
Score = 64.3 bits (155), Expect = 1e-10
Identities = 38/127 (29%), Positives = 63/127 (49%), Gaps = 11/127 (8%)
Query: 99 LQVKVLKAADLLAADFSGKSDPFCLLELGNDRLQTHTVYKNLNPEWNKVFTFPIKDIHDV 158
+ + V+ A L A D +G SDP+ +++G + +T T+Y NLNP W + F F + D
Sbjct: 766 ISITVVCAQGLQAKDKTGSSDPYVTVQVGKTKKRTKTIYGNLNPVWEENFHFECHNSSDR 825
Query: 159 LEVTVFDEDGD-----------KPPDFLGKVAIPLLSIRDGQPNCYVLKNKDLEQAFKGV 207
++V V+DED D + DFLG+ I + ++ Y L + + A G
Sbjct: 826 IKVRVWDEDDDIKSRVKQRFKRESDDFLGQTIIEVRTLSGEMDVWYNLDKRTDKSAVSGA 885
Query: 208 IYLEMDL 214
I L + +
Sbjct: 886 IRLHISV 892
>gi|45387945 family with sequence similarity 62 (C2 domain
containing) member B [Homo sapiens]
Length = 893
Score = 63.5 bits (153), Expect = 2e-10
Identities = 34/96 (35%), Positives = 56/96 (58%), Gaps = 8/96 (8%)
Query: 97 GILQVKVLKAADLLAAD------FSGKSDPFCLLELGNDRLQTHTVYKNLNPEWNKVF-T 149
G+L++ ++A DL D GKSDP+ ++ +GN Q+ + +NL+P+WN+V+
Sbjct: 357 GVLRIHFIEAQDLQGKDTYLKGLVKGKSDPYGIIRVGNQIFQSRVIKENLSPKWNEVYEA 416
Query: 150 FPIKDIHDVLEVTVFDEDGDKPPDFLGKVAIPLLSI 185
+ LE+ +FDED DK DFLG + I L+ +
Sbjct: 417 LVYEHPGQELEIELFDEDPDK-DDFLGSLMIDLIEV 451
Score = 30.4 bits (67), Expect = 2.0
Identities = 29/94 (30%), Positives = 42/94 (44%), Gaps = 10/94 (10%)
Query: 101 VKVLKAADLLAADFSGKSDPFCLLELGND-----RLQTHTVYKNLNPEWNKVFTFPI--- 152
+ V+ A L A SDP+ + L D R +TH K LNP +++ F F +
Sbjct: 776 IVVVHACRNLIAFSEDGSDPYVRMYLLPDKRRSGRRKTHVSKKTLNPVFDQSFDFSVSLP 835
Query: 153 KDIHDVLEVTVFDEDG--DKPPDFLGKVAIPLLS 184
+ L+V V + G K LGKV + L S
Sbjct: 836 EVQRRTLDVAVKNSGGFLSKDKGLLGKVLVALAS 869
>gi|110611226 UNC13 (C. elegans)-like [Homo sapiens]
Length = 1591
Score = 62.0 bits (149), Expect = 6e-10
Identities = 36/127 (28%), Positives = 64/127 (50%), Gaps = 11/127 (8%)
Query: 99 LQVKVLKAADLLAADFSGKSDPFCLLELGNDRLQTHTVYKNLNPEWNKVFTFPIKDIHDV 158
+ + V+ A L A D +G SDP+ +++ + +T T++ NLNP W + F F + D
Sbjct: 602 ITITVVCAQGLQAKDKTGSSDPYVTVQVSKTKKRTKTIFGNLNPVWEEKFHFECHNSSDR 661
Query: 159 LEVTVFDEDGD-----------KPPDFLGKVAIPLLSIRDGQPNCYVLKNKDLEQAFKGV 207
++V V+DED D + DFLG+ I + ++ Y L+ + + A G
Sbjct: 662 IKVRVWDEDDDIKSRVKQRLKRESDDFLGQTIIEVRTLSGEMDVWYNLEKRTDKSAVSGA 721
Query: 208 IYLEMDL 214
I L++ +
Sbjct: 722 IRLQISV 728
>gi|114520609 neural precursor cell expressed, developmentally
down-regulated 4 isoform 1 [Homo sapiens]
Length = 900
Score = 60.5 bits (145), Expect = 2e-09
Identities = 43/143 (30%), Positives = 68/143 (47%), Gaps = 16/143 (11%)
Query: 90 LKDVKDVGILQVKVLKAADLLAADFSGKSDPFCLLELGNDR------LQTHTVYKNLNPE 143
L+D ++ I++V+V+ L D G SDP+ + L + +QT T+ K+LNP+
Sbjct: 12 LEDEENSRIVRVRVIAGIGLAKKDILGASDPYVRVTLYDPMNGVLTSVQTKTIKKSLNPK 71
Query: 144 WNKVFTFPIKDIHDVLEVTVFDEDGDKPPDFLGKVAIPLLSIRDGQPNC--------YVL 195
WN+ F + L VFDE+ DFLG+V +PL + P +VL
Sbjct: 72 WNEEILFRVHPQQHRLLFEVFDENRLTRDDFLGQVDVPLYPLPTENPRLERPYTFKDFVL 131
Query: 196 KNKDLEQAFKGVIYLEMDLIYNP 218
+ + KG YL + + Y P
Sbjct: 132 HPRSHKSRVKG--YLRLKMTYLP 152
>gi|150170670 piccolo isoform 2 [Homo sapiens]
Length = 4935
Score = 57.0 bits (136), Expect = 2e-08
Identities = 44/124 (35%), Positives = 60/124 (48%), Gaps = 20/124 (16%)
Query: 95 DVGILQVKVLKAADLLAADFSGKSDPFCLLELGNDRLQ--------------THTVYKNL 140
D+G L + +L+A +L+ D +G SDPF + L R Q T V K+L
Sbjct: 4705 DLGNLIIHILQARNLVPRDNNGYSDPFVKVYLLPGRGQVMVVQNASAEYKRRTKHVQKSL 4764
Query: 141 NPEWNKVFTFPIKDIHDV----LEVTVFDEDGDKPPDFLGKVAIPLLSIR--DGQPNCYV 194
NPEWN+ + + + LEVTV+D D DFLG+V I L S D P Y
Sbjct: 4765 NPEWNQTVIYKSISMEQLKKKTLEVTVWDYDRFSSNDFLGEVLIDLSSTSHLDNTPRWYP 4824
Query: 195 LKNK 198
LK +
Sbjct: 4825 LKEQ 4828
>gi|150378539 piccolo isoform 1 [Homo sapiens]
Length = 5142
Score = 57.0 bits (136), Expect = 2e-08
Identities = 44/124 (35%), Positives = 60/124 (48%), Gaps = 20/124 (16%)
Query: 95 DVGILQVKVLKAADLLAADFSGKSDPFCLLELGNDRLQ--------------THTVYKNL 140
D+G L + +L+A +L+ D +G SDPF + L R Q T V K+L
Sbjct: 4705 DLGNLIIHILQARNLVPRDNNGYSDPFVKVYLLPGRGQVMVVQNASAEYKRRTKHVQKSL 4764
Query: 141 NPEWNKVFTFPIKDIHDV----LEVTVFDEDGDKPPDFLGKVAIPLLSIR--DGQPNCYV 194
NPEWN+ + + + LEVTV+D D DFLG+V I L S D P Y
Sbjct: 4765 NPEWNQTVIYKSISMEQLKKKTLEVTVWDYDRFSSNDFLGEVLIDLSSTSHLDNTPRWYP 4824
Query: 195 LKNK 198
LK +
Sbjct: 4825 LKEQ 4828
>gi|6005997 double C2-like domains, beta [Homo sapiens]
Length = 412
Score = 56.2 bits (134), Expect = 3e-08
Identities = 57/205 (27%), Positives = 86/205 (41%), Gaps = 33/205 (16%)
Query: 4 LDIEVWGKDNKKHEERLGTCKVDISALPLKQANCLELPLDSCLGALLMLVTLTPCAGVSV 63
L I V +D +H E +G +V + L + L+ L
Sbjct: 212 LRISVCDEDKFRHNEFIGETRVPLKKLKPNHTKTFNICLEKQLPV--------------- 256
Query: 64 SDLCVCPLADLSERKQITQRYCLQNSLKDVKDVGILQVKVLKAADLLAADFSGKSDPFCL 123
D +E K + +R + SLK L V +++ A L A D +G SDP+
Sbjct: 257 ---------DKTEDKSLEERGRILISLKYSSQKQGLLVGIVRCAHLAAMDANGYSDPYVK 307
Query: 124 LELGND-----RLQTHTVYKNLNPEWNKVFTFPIKD---IHDVLEVTVFDEDGDKPPDFL 175
L D + +T K LNPE+N+ F + IK LEVTV+D D K DF+
Sbjct: 308 TYLRPDVDKKSKHKTAVKKKTLNPEFNEEFCYEIKHGDLAKKSLEVTVWDYDIGKSNDFI 367
Query: 176 GKVAIPLLSIRDGQPNCY-VLKNKD 199
G V + + + + + + LKNKD
Sbjct: 368 GGVVLGIHAKGERLKHWFDCLKNKD 392
Score = 52.4 bits (124), Expect = 5e-07
Identities = 39/126 (30%), Positives = 60/126 (47%), Gaps = 9/126 (7%)
Query: 70 PLADLSERKQITQRYCLQNSLKDVKDVGILQVKVLKAADLLAADFSGKSDPFCLLEL--- 126
P AD E T L SL ++ L + KA L D +G +DP+ L L
Sbjct: 114 PDADGYESDDCTALGTLDFSLLYDQENNALHCTITKAKGLKPMDHNGLADPYVKLHLLPG 173
Query: 127 --GNDRLQTHTVYKNLNPEWNKVFT-FPIKD---IHDVLEVTVFDEDGDKPPDFLGKVAI 180
++L+T T+ LNP WN+ T + I D I L ++V DED + +F+G+ +
Sbjct: 174 ASKANKLRTKTLRNTLNPTWNETLTYYGITDEDMIRKTLRISVCDEDKFRHNEFIGETRV 233
Query: 181 PLLSIR 186
PL ++
Sbjct: 234 PLKKLK 239
>gi|239743307 PREDICTED: similar to calcium-promoted Ras inactivator
isoform 1 [Homo sapiens]
Length = 757
Score = 55.8 bits (133), Expect = 5e-08
Identities = 44/181 (24%), Positives = 85/181 (46%), Gaps = 15/181 (8%)
Query: 99 LQVKVLKAADLLAADFSGKSDPFCLLELGNDR-LQTHTVYKNLNPEWNKVFTFPIKDIHD 157
L +++++ +L A D +G SDP+C++++ N+ ++T TV+K L P W + + +
Sbjct: 7 LYIRIVEGKNLPAKDITGSSDPYCIVKVDNEPIIRTATVWKTLCPFWGEEYQVHLPPTFH 66
Query: 158 VLEVTVFDEDGDKPPDFLGKVAI---PLLSIRDGQPNCYVLKNKDLEQAFKGVIYLEMDL 214
+ V DED D +GKV + + S G L D ++ +G I+L ++
Sbjct: 67 AVAFYVMDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEIHLRLE- 125
Query: 215 IYNPVKA--------SIRTFTPREKRFVEDS-RKLSKKILSRDVDRVKRITMAIWN-TMQ 264
++ +A R P+++ D ++ K +R+ VK+ WN T +
Sbjct: 126 VWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFE 185
Query: 265 F 265
F
Sbjct: 186 F 186
Score = 52.0 bits (123), Expect = 7e-07
Identities = 32/89 (35%), Positives = 46/89 (51%), Gaps = 1/89 (1%)
Query: 99 LQVKVLKAADLLAADFSGKSDPFCLLELGNDRLQTHTVYKNLNPEWNKVFTFPIKD-IHD 157
L+ VL+A DL D +G SDPF + +T V K+ P WN+ F F +++ +
Sbjct: 135 LRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEGAME 194
Query: 158 VLEVTVFDEDGDKPPDFLGKVAIPLLSIR 186
L V +D D DFLGKV I + +R
Sbjct: 195 ALCVEAWDWDLVSRNDFLGKVVIDVQRLR 223
>gi|239508990 PREDICTED: similar to calcium-promoted Ras inactivator
isoform 2 [Homo sapiens]
Length = 757
Score = 55.8 bits (133), Expect = 5e-08
Identities = 44/181 (24%), Positives = 85/181 (46%), Gaps = 15/181 (8%)
Query: 99 LQVKVLKAADLLAADFSGKSDPFCLLELGNDR-LQTHTVYKNLNPEWNKVFTFPIKDIHD 157
L +++++ +L A D +G SDP+C++++ N+ ++T TV+K L P W + + +
Sbjct: 7 LYIRIVEGKNLPAKDITGSSDPYCIVKVDNEPIIRTATVWKTLCPFWGEEYQVHLPPTFH 66
Query: 158 VLEVTVFDEDGDKPPDFLGKVAI---PLLSIRDGQPNCYVLKNKDLEQAFKGVIYLEMDL 214
+ V DED D +GKV + + S G L D ++ +G I+L ++
Sbjct: 67 AVAFYVMDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEIHLRLE- 125
Query: 215 IYNPVKA--------SIRTFTPREKRFVEDS-RKLSKKILSRDVDRVKRITMAIWN-TMQ 264
++ +A R P+++ D ++ K +R+ VK+ WN T +
Sbjct: 126 VWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFE 185
Query: 265 F 265
F
Sbjct: 186 F 186
Score = 52.0 bits (123), Expect = 7e-07
Identities = 32/89 (35%), Positives = 46/89 (51%), Gaps = 1/89 (1%)
Query: 99 LQVKVLKAADLLAADFSGKSDPFCLLELGNDRLQTHTVYKNLNPEWNKVFTFPIKD-IHD 157
L+ VL+A DL D +G SDPF + +T V K+ P WN+ F F +++ +
Sbjct: 135 LRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEGAME 194
Query: 158 VLEVTVFDEDGDKPPDFLGKVAIPLLSIR 186
L V +D D DFLGKV I + +R
Sbjct: 195 ALCVEAWDWDLVSRNDFLGKVVIDVQRLR 223
>gi|121114292 RAS p21 protein activator 4 isoform 2 [Homo sapiens]
Length = 757
Score = 55.8 bits (133), Expect = 5e-08
Identities = 44/181 (24%), Positives = 85/181 (46%), Gaps = 15/181 (8%)
Query: 99 LQVKVLKAADLLAADFSGKSDPFCLLELGNDR-LQTHTVYKNLNPEWNKVFTFPIKDIHD 157
L +++++ +L A D +G SDP+C++++ N+ ++T TV+K L P W + + +
Sbjct: 7 LYIRIVEGKNLPAKDITGSSDPYCIVKVDNEPIIRTATVWKTLCPFWGEEYQVHLPPTFH 66
Query: 158 VLEVTVFDEDGDKPPDFLGKVAI---PLLSIRDGQPNCYVLKNKDLEQAFKGVIYLEMDL 214
+ V DED D +GKV + + S G L D ++ +G I+L ++
Sbjct: 67 AVAFYVMDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEIHLRLE- 125
Query: 215 IYNPVKA--------SIRTFTPREKRFVEDS-RKLSKKILSRDVDRVKRITMAIWN-TMQ 264
++ +A R P+++ D ++ K +R+ VK+ WN T +
Sbjct: 126 VWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFE 185
Query: 265 F 265
F
Sbjct: 186 F 186
Score = 52.0 bits (123), Expect = 7e-07
Identities = 32/89 (35%), Positives = 46/89 (51%), Gaps = 1/89 (1%)
Query: 99 LQVKVLKAADLLAADFSGKSDPFCLLELGNDRLQTHTVYKNLNPEWNKVFTFPIKD-IHD 157
L+ VL+A DL D +G SDPF + +T V K+ P WN+ F F +++ +
Sbjct: 135 LRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEGAME 194
Query: 158 VLEVTVFDEDGDKPPDFLGKVAIPLLSIR 186
L V +D D DFLGKV I + +R
Sbjct: 195 ALCVEAWDWDLVSRNDFLGKVVIDVQRLR 223
>gi|121114294 RAS p21 protein activator 4 isoform 1 [Homo sapiens]
Length = 803
Score = 55.8 bits (133), Expect = 5e-08
Identities = 44/181 (24%), Positives = 85/181 (46%), Gaps = 15/181 (8%)
Query: 99 LQVKVLKAADLLAADFSGKSDPFCLLELGNDR-LQTHTVYKNLNPEWNKVFTFPIKDIHD 157
L +++++ +L A D +G SDP+C++++ N+ ++T TV+K L P W + + +
Sbjct: 7 LYIRIVEGKNLPAKDITGSSDPYCIVKVDNEPIIRTATVWKTLCPFWGEEYQVHLPPTFH 66
Query: 158 VLEVTVFDEDGDKPPDFLGKVAI---PLLSIRDGQPNCYVLKNKDLEQAFKGVIYLEMDL 214
+ V DED D +GKV + + S G L D ++ +G I+L ++
Sbjct: 67 AVAFYVMDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEIHLRLE- 125
Query: 215 IYNPVKA--------SIRTFTPREKRFVEDS-RKLSKKILSRDVDRVKRITMAIWN-TMQ 264
++ +A R P+++ D ++ K +R+ VK+ WN T +
Sbjct: 126 VWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFE 185
Query: 265 F 265
F
Sbjct: 186 F 186
Score = 52.0 bits (123), Expect = 7e-07
Identities = 32/89 (35%), Positives = 46/89 (51%), Gaps = 1/89 (1%)
Query: 99 LQVKVLKAADLLAADFSGKSDPFCLLELGNDRLQTHTVYKNLNPEWNKVFTFPIKD-IHD 157
L+ VL+A DL D +G SDPF + +T V K+ P WN+ F F +++ +
Sbjct: 135 LRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEGAME 194
Query: 158 VLEVTVFDEDGDKPPDFLGKVAIPLLSIR 186
L V +D D DFLGKV I + +R
Sbjct: 195 ALCVEAWDWDLVSRNDFLGKVVIDVQRLR 223
>gi|47078261 double C2-like domains, alpha [Homo sapiens]
Length = 400
Score = 54.7 bits (130), Expect = 1e-07
Identities = 34/100 (34%), Positives = 52/100 (52%), Gaps = 9/100 (9%)
Query: 99 LQVKVLKAADLLAADFSGKSDPFCLLEL-----GNDRLQTHTVYKNLNPEWNKVFTFP-I 152
L +L+A L DF+G +DP+ L L ++L+T T LNP WN+ T+ I
Sbjct: 106 LHCSILRAKGLKPMDFNGLADPYVKLHLLPGACKANKLKTKTQRNTLNPVWNEDLTYSGI 165
Query: 153 KD---IHDVLEVTVFDEDGDKPPDFLGKVAIPLLSIRDGQ 189
D H VL + V DED +F+G++ +PL ++ Q
Sbjct: 166 TDDDITHKVLRIAVCDEDKLSHNEFIGEIRVPLRRLKPSQ 205
Score = 52.8 bits (125), Expect = 4e-07
Identities = 54/190 (28%), Positives = 83/190 (43%), Gaps = 18/190 (9%)
Query: 3 ILDIEVWGKDNKKHEERLGTCKVDISALPLKQANCLELPLDSCLGALLMLVTLTPCAGVS 62
+L I V +D H E +G +V + L Q + L+ + G+S
Sbjct: 174 VLRIAVCDEDKLSHNEFIGEIRVPLRRLKPSQKKHFNICLERQVPLASPSSMSAALRGIS 233
Query: 63 VSDLCVCPLADLSERKQ----ITQRYCLQNSLKDVKDVGILQVKVLKAADLLAADFSGKS 118
C L +L + +Q + +R + SL L V +L+ A L A D +G S
Sbjct: 234 ------CYLKELEQAEQGQGLLEERGRILLSLSYSSRRRGLLVGILRCAHLAAMDVNGYS 287
Query: 119 DPFCLLELGND-----RLQTHTVYKNLNPEWNKVFTFPIKD---IHDVLEVTVFDEDGDK 170
DP+ L D + +T K LNPE+N+ F + I+ LEVTV+D D K
Sbjct: 288 DPYVKTYLRPDVDKKSKHKTCVKKKTLNPEFNEEFFYEIELSTLATKTLEVTVWDYDIGK 347
Query: 171 PPDFLGKVAI 180
DF+G V++
Sbjct: 348 SNDFIGGVSL 357
>gi|211059429 synaptotagmin II [Homo sapiens]
Length = 419
Score = 54.3 bits (129), Expect = 1e-07
Identities = 39/111 (35%), Positives = 59/111 (53%), Gaps = 6/111 (5%)
Query: 86 LQNSLKDVKDVGILQVKVLKAADLLAADFSGKSDPFCLLELGNDR---LQTHTVYKNLNP 142
LQ SL L V VL+AA+L A D G SDP+ + L D+ +T K LNP
Sbjct: 143 LQFSLDYDFQANQLTVGVLQAAELPALDMGGTSDPYVKVFLLPDKKKKYETKVHRKTLNP 202
Query: 143 EWNKVFTF--PIKDIHD-VLEVTVFDEDGDKPPDFLGKVAIPLLSIRDGQP 190
+N+ FTF P +++ L + ++D D D +G+V +P+ ++ GQP
Sbjct: 203 AFNETFTFKVPYQELGGKTLVMAIYDFDRFSKHDIIGEVKVPMNTVDLGQP 253
Score = 42.7 bits (99), Expect = 4e-04
Identities = 33/100 (33%), Positives = 51/100 (51%), Gaps = 8/100 (8%)
Query: 89 SLKDVKDVGILQVKVLKAADLLAADFSGKSDPFCLLELGND-----RLQTHTVYKNLNPE 143
SL+ V G L V +L+A +L D G SDP+ + L + + +T K LNP
Sbjct: 277 SLRYVPTAGKLTVCILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTVKKKTLNPY 336
Query: 144 WNKVFTF--PIKDIHDV-LEVTVFDEDGDKPPDFLGKVAI 180
+N+ F+F P + I V + VTV D D + +GK+ +
Sbjct: 337 FNESFSFEIPFEQIQKVQVVVTVLDYDKLGKNEAIGKIFV 376
>gi|31543670 synaptotagmin II [Homo sapiens]
Length = 419
Score = 54.3 bits (129), Expect = 1e-07
Identities = 39/111 (35%), Positives = 59/111 (53%), Gaps = 6/111 (5%)
Query: 86 LQNSLKDVKDVGILQVKVLKAADLLAADFSGKSDPFCLLELGNDR---LQTHTVYKNLNP 142
LQ SL L V VL+AA+L A D G SDP+ + L D+ +T K LNP
Sbjct: 143 LQFSLDYDFQANQLTVGVLQAAELPALDMGGTSDPYVKVFLLPDKKKKYETKVHRKTLNP 202
Query: 143 EWNKVFTF--PIKDIHD-VLEVTVFDEDGDKPPDFLGKVAIPLLSIRDGQP 190
+N+ FTF P +++ L + ++D D D +G+V +P+ ++ GQP
Sbjct: 203 AFNETFTFKVPYQELGGKTLVMAIYDFDRFSKHDIIGEVKVPMNTVDLGQP 253
Score = 42.7 bits (99), Expect = 4e-04
Identities = 33/100 (33%), Positives = 51/100 (51%), Gaps = 8/100 (8%)
Query: 89 SLKDVKDVGILQVKVLKAADLLAADFSGKSDPFCLLELGND-----RLQTHTVYKNLNPE 143
SL+ V G L V +L+A +L D G SDP+ + L + + +T K LNP
Sbjct: 277 SLRYVPTAGKLTVCILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTVKKKTLNPY 336
Query: 144 WNKVFTF--PIKDIHDV-LEVTVFDEDGDKPPDFLGKVAI 180
+N+ F+F P + I V + VTV D D + +GK+ +
Sbjct: 337 FNESFSFEIPFEQIQKVQVVVTVLDYDKLGKNEAIGKIFV 376
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.138 0.419
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 11,546,180
Number of Sequences: 37866
Number of extensions: 477018
Number of successful extensions: 1428
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 68
Number of HSP's successfully gapped in prelim test: 70
Number of HSP's that attempted gapping in prelim test: 1153
Number of HSP's gapped (non-prelim): 283
length of query: 306
length of database: 18,247,518
effective HSP length: 102
effective length of query: 204
effective length of database: 14,385,186
effective search space: 2934577944
effective search space used: 2934577944
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.