BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens] (3899 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens] 7479 0.0 gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens] 7472 0.0 gi|81295809 pericentrin [Homo sapiens] 310 2e-83 gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 306 3e-82 gi|55770834 centromere protein F [Homo sapiens] 285 5e-76 gi|71061468 centromere protein E [Homo sapiens] 239 5e-62 gi|109255234 centrosomal protein 290kDa [Homo sapiens] 233 4e-60 gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 231 1e-59 gi|21735548 centrosomal protein 2 [Homo sapiens] 210 3e-53 gi|148746195 trichohyalin [Homo sapiens] 199 6e-50 gi|41322923 plectin 1 isoform 11 [Homo sapiens] 192 7e-48 gi|41322914 plectin 1 isoform 10 [Homo sapiens] 192 7e-48 gi|41322919 plectin 1 isoform 8 [Homo sapiens] 192 7e-48 gi|41322910 plectin 1 isoform 7 [Homo sapiens] 192 7e-48 gi|41322916 plectin 1 isoform 6 [Homo sapiens] 192 7e-48 gi|41322908 plectin 1 isoform 3 [Homo sapiens] 192 7e-48 gi|41322912 plectin 1 isoform 2 [Homo sapiens] 192 7e-48 gi|47607492 plectin 1 isoform 1 [Homo sapiens] 192 7e-48 gi|114155142 nuclear pore complex-associated protein TPR [Homo s... 182 6e-45 gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens] 179 6e-44 gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens] 176 3e-43 gi|153791497 ciliary rootlet coiled-coil [Homo sapiens] 176 3e-43 gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 172 4e-42 gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 167 2e-40 gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 166 4e-40 gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 162 8e-39 gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 159 4e-38 gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 157 3e-37 gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 157 3e-37 gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 157 3e-37 >gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens] Length = 3899 Score = 7479 bits (19406), Expect = 0.0 Identities = 3899/3899 (100%), Positives = 3899/3899 (100%) Query: 1 MEDEERQKKLEAGKAKLAQFRQRKAQSDGQSPSKKQKKKRKTSSSKHDVSAHHDLNIDQS 60 MEDEERQKKLEAGKAKLAQFRQRKAQSDGQSPSKKQKKKRKTSSSKHDVSAHHDLNIDQS Sbjct: 1 MEDEERQKKLEAGKAKLAQFRQRKAQSDGQSPSKKQKKKRKTSSSKHDVSAHHDLNIDQS 60 Query: 61 QCNEMYINSSQRVESTVIPESTIMRTLHSGEITSHEQGFSVELESEISTTADDCSSEVNG 120 QCNEMYINSSQRVESTVIPESTIMRTLHSGEITSHEQGFSVELESEISTTADDCSSEVNG Sbjct: 61 QCNEMYINSSQRVESTVIPESTIMRTLHSGEITSHEQGFSVELESEISTTADDCSSEVNG 120 Query: 121 CSFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHEIEELNRELEE 180 CSFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHEIEELNRELEE Sbjct: 121 CSFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHEIEELNRELEE 180 Query: 181 MRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQI 240 MRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQI Sbjct: 181 MRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQI 240 Query: 241 QFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISF 300 QFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISF Sbjct: 241 QFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISF 300 Query: 301 LQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLG 360 LQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLG Sbjct: 301 LQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLG 360 Query: 361 ELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQ 420 ELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQ Sbjct: 361 ELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQ 420 Query: 421 RMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSN 480 RMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSN Sbjct: 421 RMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSN 480 Query: 481 ITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFS 540 ITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFS Sbjct: 481 ITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFS 540 Query: 541 REQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKL 600 REQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKL Sbjct: 541 REQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKL 600 Query: 601 EMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLG 660 EMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLG Sbjct: 601 EMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLG 660 Query: 661 IHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQ 720 IHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQ Sbjct: 661 IHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQ 720 Query: 721 INELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSIL 780 INELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSIL Sbjct: 721 INELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSIL 780 Query: 781 KDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLN 840 KDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLN Sbjct: 781 KDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLN 840 Query: 841 EEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEEL 900 EEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEEL Sbjct: 841 EEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEEL 900 Query: 901 HLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLS 960 HLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLS Sbjct: 901 HLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLS 960 Query: 961 DLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLL 1020 DLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLL Sbjct: 961 DLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLL 1020 Query: 1021 DGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTK 1080 DGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTK Sbjct: 1021 DGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTK 1080 Query: 1081 ESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKD 1140 ESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKD Sbjct: 1081 ESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKD 1140 Query: 1141 KALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECS 1200 KALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECS Sbjct: 1141 KALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECS 1200 Query: 1201 YFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLL 1260 YFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLL Sbjct: 1201 YFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLL 1260 Query: 1261 NKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVN 1320 NKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVN Sbjct: 1261 NKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVN 1320 Query: 1321 HKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSESTV 1380 HKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSESTV Sbjct: 1321 HKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSESTV 1380 Query: 1381 PPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQL 1440 PPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQL Sbjct: 1381 PPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQL 1440 Query: 1441 EEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGF 1500 EEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGF Sbjct: 1441 EEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGF 1500 Query: 1501 QTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFI 1560 QTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFI Sbjct: 1501 QTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFI 1560 Query: 1561 VRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQR 1620 VRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQR Sbjct: 1561 VRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQR 1620 Query: 1621 EDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRN 1680 EDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRN Sbjct: 1621 EDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRN 1680 Query: 1681 SSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVK 1740 SSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVK Sbjct: 1681 SSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVK 1740 Query: 1741 TTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSG 1800 TTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSG Sbjct: 1741 TTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSG 1800 Query: 1801 SDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEA 1860 SDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEA Sbjct: 1801 SDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEA 1860 Query: 1861 ISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKA 1920 ISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKA Sbjct: 1861 ISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKA 1920 Query: 1921 EGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQK 1980 EGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQK Sbjct: 1921 EGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQK 1980 Query: 1981 EAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIEL 2040 EAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIEL Sbjct: 1981 EAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIEL 2040 Query: 2041 EQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRF 2100 EQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRF Sbjct: 2041 EQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRF 2100 Query: 2101 QPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQAL 2160 QPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQAL Sbjct: 2101 QPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQAL 2160 Query: 2161 LVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQ 2220 LVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQ Sbjct: 2161 LVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQ 2220 Query: 2221 LHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQ 2280 LHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQ Sbjct: 2221 LHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQ 2280 Query: 2281 EKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEE 2340 EKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEE Sbjct: 2281 EKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEE 2340 Query: 2341 IEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEE 2400 IEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEE Sbjct: 2341 IEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEE 2400 Query: 2401 MTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVV 2460 MTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVV Sbjct: 2401 MTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVV 2460 Query: 2461 LTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQ 2520 LTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQ Sbjct: 2461 LTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQ 2520 Query: 2521 GQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQN 2580 GQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQN Sbjct: 2521 GQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQN 2580 Query: 2581 LNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQK 2640 LNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQK Sbjct: 2581 LNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQK 2640 Query: 2641 LLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASY 2700 LLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASY Sbjct: 2641 LLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASY 2700 Query: 2701 KEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFE 2760 KEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFE Sbjct: 2701 KEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFE 2760 Query: 2761 PLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTEIISQFTEKI 2820 PLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTEIISQFTEKI Sbjct: 2761 PLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTEIISQFTEKI 2820 Query: 2821 EKMQELHAAEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPE 2880 EKMQELHAAEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPE Sbjct: 2821 EKMQELHAAEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPE 2880 Query: 2881 LAHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESESATDSFPKKIKGLLR 2940 LAHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESESATDSFPKKIKGLLR Sbjct: 2881 LAHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESESATDSFPKKIKGLLR 2940 Query: 2941 AVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINTISSLKDLITKMQLQREAE 3000 AVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINTISSLKDLITKMQLQREAE Sbjct: 2941 AVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINTISSLKDLITKMQLQREAE 3000 Query: 3001 VYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRI 3060 VYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRI Sbjct: 3001 VYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRI 3060 Query: 3061 QEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQ 3120 QEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQ Sbjct: 3061 QEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQ 3120 Query: 3121 KQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKE 3180 KQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKE Sbjct: 3121 KQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKE 3180 Query: 3181 LEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFS 3240 LEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFS Sbjct: 3181 LEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFS 3240 Query: 3241 LESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVR 3300 LESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVR Sbjct: 3241 LESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVR 3300 Query: 3301 IREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEK 3360 IREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEK Sbjct: 3301 IREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEK 3360 Query: 3361 YKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYK 3420 YKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYK Sbjct: 3361 YKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYK 3420 Query: 3421 LDLEGQRLQGIMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEG 3480 LDLEGQRLQGIMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEG Sbjct: 3421 LDLEGQRLQGIMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEG 3480 Query: 3481 ETKESNYAKLIEMNGGGTGCNHELEMIRQKLQCVASKLQVLPQKASERLQFETADDEDFI 3540 ETKESNYAKLIEMNGGGTGCNHELEMIRQKLQCVASKLQVLPQKASERLQFETADDEDFI Sbjct: 3481 ETKESNYAKLIEMNGGGTGCNHELEMIRQKLQCVASKLQVLPQKASERLQFETADDEDFI 3540 Query: 3541 WVQENIDEIILQLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKND 3600 WVQENIDEIILQLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKND Sbjct: 3541 WVQENIDEIILQLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKND 3600 Query: 3601 LRNMVMKLEEQIRWYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKR 3660 LRNMVMKLEEQIRWYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKR Sbjct: 3601 LRNMVMKLEEQIRWYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKR 3660 Query: 3661 AEAEVYKLKAELRNDSLLQTLSPDSEHVTLKRIYGKYLRAESFRKALIYQKKYLLLLLGG 3720 AEAEVYKLKAELRNDSLLQTLSPDSEHVTLKRIYGKYLRAESFRKALIYQKKYLLLLLGG Sbjct: 3661 AEAEVYKLKAELRNDSLLQTLSPDSEHVTLKRIYGKYLRAESFRKALIYQKKYLLLLLGG 3720 Query: 3721 FQECEDATLALLARMGGQPAFTDLEVITNRPKGFTRFRSAVRVSIAISRMKFLVRRWHRV 3780 FQECEDATLALLARMGGQPAFTDLEVITNRPKGFTRFRSAVRVSIAISRMKFLVRRWHRV Sbjct: 3721 FQECEDATLALLARMGGQPAFTDLEVITNRPKGFTRFRSAVRVSIAISRMKFLVRRWHRV 3780 Query: 3781 TGSVSININRDGFGLNQGAEKTDSFYHSSGGLELYGEPRHTTYRSRSDLDYIRSPLPFQN 3840 TGSVSININRDGFGLNQGAEKTDSFYHSSGGLELYGEPRHTTYRSRSDLDYIRSPLPFQN Sbjct: 3781 TGSVSININRDGFGLNQGAEKTDSFYHSSGGLELYGEPRHTTYRSRSDLDYIRSPLPFQN 3840 Query: 3841 RYPGTPADFNPGSLACSQLQNYDPDRALTDYITRLEALQRRLGTIQSGSTTQFHAGMRR 3899 RYPGTPADFNPGSLACSQLQNYDPDRALTDYITRLEALQRRLGTIQSGSTTQFHAGMRR Sbjct: 3841 RYPGTPADFNPGSLACSQLQNYDPDRALTDYITRLEALQRRLGTIQSGSTTQFHAGMRR 3899 >gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens] Length = 3907 Score = 7472 bits (19387), Expect = 0.0 Identities = 3899/3907 (99%), Positives = 3899/3907 (99%), Gaps = 8/3907 (0%) Query: 1 MEDEERQKKLEAGKAKLAQFRQRKAQSDGQSPSKKQKKKRKTSSSKHDVSAHHDLNIDQS 60 MEDEERQKKLEAGKAKLAQFRQRKAQSDGQSPSKKQKKKRKTSSSKHDVSAHHDLNIDQS Sbjct: 1 MEDEERQKKLEAGKAKLAQFRQRKAQSDGQSPSKKQKKKRKTSSSKHDVSAHHDLNIDQS 60 Query: 61 QCNEMYINSSQRVESTVIPESTIMRTLHSGEITSHEQGFSVELESEISTTADDCSSEVNG 120 QCNEMYINSSQRVESTVIPESTIMRTLHSGEITSHEQGFSVELESEISTTADDCSSEVNG Sbjct: 61 QCNEMYINSSQRVESTVIPESTIMRTLHSGEITSHEQGFSVELESEISTTADDCSSEVNG 120 Query: 121 CSFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHEIEELNRELEE 180 CSFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHEIEELNRELEE Sbjct: 121 CSFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHEIEELNRELEE 180 Query: 181 MRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQI 240 MRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQI Sbjct: 181 MRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQI 240 Query: 241 QFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISF 300 QFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISF Sbjct: 241 QFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISF 300 Query: 301 LQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLG 360 LQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLG Sbjct: 301 LQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLG 360 Query: 361 ELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQ 420 ELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQ Sbjct: 361 ELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQ 420 Query: 421 RMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSN 480 RMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSN Sbjct: 421 RMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSN 480 Query: 481 ITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFS 540 ITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFS Sbjct: 481 ITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFS 540 Query: 541 REQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKL 600 REQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKL Sbjct: 541 REQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKL 600 Query: 601 EMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLG 660 EMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLG Sbjct: 601 EMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLG 660 Query: 661 IHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQ 720 IHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQ Sbjct: 661 IHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQ 720 Query: 721 INELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSIL 780 INELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSIL Sbjct: 721 INELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSIL 780 Query: 781 KDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLN 840 KDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLN Sbjct: 781 KDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLN 840 Query: 841 EEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEEL 900 EEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEEL Sbjct: 841 EEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEEL 900 Query: 901 HLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLS 960 HLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLS Sbjct: 901 HLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLS 960 Query: 961 DLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLL 1020 DLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLL Sbjct: 961 DLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLL 1020 Query: 1021 DGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTK 1080 DGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTK Sbjct: 1021 DGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTK 1080 Query: 1081 ESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKD 1140 ESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKD Sbjct: 1081 ESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKD 1140 Query: 1141 KALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECS 1200 KALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECS Sbjct: 1141 KALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECS 1200 Query: 1201 YFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLL 1260 YFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLL Sbjct: 1201 YFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLL 1260 Query: 1261 NKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVN 1320 NKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVN Sbjct: 1261 NKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVN 1320 Query: 1321 HKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSESTV 1380 HKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSESTV Sbjct: 1321 HKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSESTV 1380 Query: 1381 PPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQL 1440 PPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQL Sbjct: 1381 PPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQL 1440 Query: 1441 EEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGF 1500 EEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGF Sbjct: 1441 EEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGF 1500 Query: 1501 QTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFI 1560 QTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFI Sbjct: 1501 QTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFI 1560 Query: 1561 VRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQR 1620 VRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQR Sbjct: 1561 VRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQR 1620 Query: 1621 EDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRN 1680 EDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRN Sbjct: 1621 EDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRN 1680 Query: 1681 SSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVK 1740 SSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVK Sbjct: 1681 SSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVK 1740 Query: 1741 TTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSG 1800 TTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSG Sbjct: 1741 TTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSG 1800 Query: 1801 SDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEA 1860 SDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEA Sbjct: 1801 SDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEA 1860 Query: 1861 ISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKA 1920 ISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKA Sbjct: 1861 ISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKA 1920 Query: 1921 EGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQK 1980 EGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQK Sbjct: 1921 EGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQK 1980 Query: 1981 EAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIEL 2040 EAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIEL Sbjct: 1981 EAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIEL 2040 Query: 2041 EQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRF 2100 EQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRF Sbjct: 2041 EQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRF 2100 Query: 2101 QPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQAL 2160 QPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQAL Sbjct: 2101 QPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQAL 2160 Query: 2161 L--------VEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELE 2212 L VEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELE Sbjct: 2161 LVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELE 2220 Query: 2213 NKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLF 2272 NKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLF Sbjct: 2221 NKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLF 2280 Query: 2273 GKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQEC 2332 GKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQEC Sbjct: 2281 GKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQEC 2340 Query: 2333 VKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQ 2392 VKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQ Sbjct: 2341 VKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQ 2400 Query: 2393 QVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSK 2452 QVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSK Sbjct: 2401 QVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSK 2460 Query: 2453 DKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYK 2512 DKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYK Sbjct: 2461 DKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYK 2520 Query: 2513 QIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSE 2572 QIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSE Sbjct: 2521 QIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSE 2580 Query: 2573 PERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKE 2632 PERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKE Sbjct: 2581 PERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKE 2640 Query: 2633 KKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVA 2692 KKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVA Sbjct: 2641 KKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVA 2700 Query: 2693 TKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQE 2752 TKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQE Sbjct: 2701 TKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQE 2760 Query: 2753 SKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTEI 2812 SKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTEI Sbjct: 2761 SKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTEI 2820 Query: 2813 ISQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRS 2872 ISQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRS Sbjct: 2821 ISQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRS 2880 Query: 2873 KEGSSIPELAHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESESATDSFP 2932 KEGSSIPELAHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESESATDSFP Sbjct: 2881 KEGSSIPELAHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESESATDSFP 2940 Query: 2933 KKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINTISSLKDLITK 2992 KKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINTISSLKDLITK Sbjct: 2941 KKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINTISSLKDLITK 3000 Query: 2993 MQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTALGTTDAVGL 3052 MQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTALGTTDAVGL Sbjct: 3001 MQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTALGTTDAVGL 3060 Query: 3053 LNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQE 3112 LNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQE Sbjct: 3061 LNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQE 3120 Query: 3113 LLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLK 3172 LLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLK Sbjct: 3121 LLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLK 3180 Query: 3173 AQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKE 3232 AQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKE Sbjct: 3181 AQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKE 3240 Query: 3233 ELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQV 3292 ELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQV Sbjct: 3241 ELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQV 3300 Query: 3293 LLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIV 3352 LLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIV Sbjct: 3301 LLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIV 3360 Query: 3353 ELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLE 3412 ELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLE Sbjct: 3361 ELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLE 3420 Query: 3413 EKRQQVYKLDLEGQRLQGIMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNW 3472 EKRQQVYKLDLEGQRLQGIMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNW Sbjct: 3421 EKRQQVYKLDLEGQRLQGIMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNW 3480 Query: 3473 VLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMIRQKLQCVASKLQVLPQKASERLQFE 3532 VLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMIRQKLQCVASKLQVLPQKASERLQFE Sbjct: 3481 VLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMIRQKLQCVASKLQVLPQKASERLQFE 3540 Query: 3533 TADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQNAELTGHIS 3592 TADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQNAELTGHIS Sbjct: 3541 TADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQNAELTGHIS 3600 Query: 3593 QLTEEKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKL 3652 QLTEEKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKL Sbjct: 3601 QLTEEKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKL 3660 Query: 3653 TLQKSLKRAEAEVYKLKAELRNDSLLQTLSPDSEHVTLKRIYGKYLRAESFRKALIYQKK 3712 TLQKSLKRAEAEVYKLKAELRNDSLLQTLSPDSEHVTLKRIYGKYLRAESFRKALIYQKK Sbjct: 3661 TLQKSLKRAEAEVYKLKAELRNDSLLQTLSPDSEHVTLKRIYGKYLRAESFRKALIYQKK 3720 Query: 3713 YLLLLLGGFQECEDATLALLARMGGQPAFTDLEVITNRPKGFTRFRSAVRVSIAISRMKF 3772 YLLLLLGGFQECEDATLALLARMGGQPAFTDLEVITNRPKGFTRFRSAVRVSIAISRMKF Sbjct: 3721 YLLLLLGGFQECEDATLALLARMGGQPAFTDLEVITNRPKGFTRFRSAVRVSIAISRMKF 3780 Query: 3773 LVRRWHRVTGSVSININRDGFGLNQGAEKTDSFYHSSGGLELYGEPRHTTYRSRSDLDYI 3832 LVRRWHRVTGSVSININRDGFGLNQGAEKTDSFYHSSGGLELYGEPRHTTYRSRSDLDYI Sbjct: 3781 LVRRWHRVTGSVSININRDGFGLNQGAEKTDSFYHSSGGLELYGEPRHTTYRSRSDLDYI 3840 Query: 3833 RSPLPFQNRYPGTPADFNPGSLACSQLQNYDPDRALTDYITRLEALQRRLGTIQSGSTTQ 3892 RSPLPFQNRYPGTPADFNPGSLACSQLQNYDPDRALTDYITRLEALQRRLGTIQSGSTTQ Sbjct: 3841 RSPLPFQNRYPGTPADFNPGSLACSQLQNYDPDRALTDYITRLEALQRRLGTIQSGSTTQ 3900 Query: 3893 FHAGMRR 3899 FHAGMRR Sbjct: 3901 FHAGMRR 3907 >gi|81295809 pericentrin [Homo sapiens] Length = 3336 Score = 310 bits (793), Expect = 2e-83 Identities = 426/1880 (22%), Positives = 792/1880 (42%), Gaps = 319/1880 (16%) Query: 656 KDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLI---LEISK---LKDLQQSL 709 +D G+H Q + GL+ +E ++ N+ T Q +L L+ K L +L++ L Sbjct: 231 EDEAGLHQSQAVHGLE------LEALRLSLSNMHTAQLELTQANLQKEKETALTELREML 284 Query: 710 VNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEK 769 + +++E+ L + Q E+E+LR++ +E +E+ L+ ++KEK EK Sbjct: 285 NSRRAQELALLQSRQQHELELLREQHA------REKEEVVLRCGQEAAELKEKLQSEMEK 338 Query: 770 FAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEE- 828 AQ+ KTL++ + E+ + L++++ K + + E+E L + Sbjct: 339 NAQIV----------KTLKEDW-------ESEKDLCLENLR-KELSAKHQSEMEDLQNQF 380 Query: 829 NEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNK--QE 886 ++L +Q +L E+I + +N A +N E ++Q A + K+++DL+ + ++ Sbjct: 381 QKELAEQRAEL-EKIFQDKNQAERALRNLESHHQ------AAIEKLREDLQSEHGRCLED 433 Query: 887 LEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLE 946 LE+K K ++L L+ + + +K+ +E + ++ L+ ++ +EL E+L Sbjct: 434 LEFKFKESEKEKQLELENLQASYEDLKAQSQEEIRRLWSQ-LDSARTSRQELSELHEQL- 491 Query: 947 VTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRA 1006 L + R+ DL EQLKQ+ EK Q +L I Sbjct: 492 ------LARTSRVEDL-EQLKQR----------------EKTQHESELEQLRIYFEKKLR 528 Query: 1007 ENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESK 1066 + ++ + T+ + +G+ E ++ D V VG E K Sbjct: 529 DAEKTYQEDL--------TLLQQRLQGA---------REDALL--DSVEVGLSCVGLEEK 569 Query: 1067 QEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYST 1126 E+ DH+ + E + + Q EL + R Q+EA L + + Sbjct: 570 PEKGRKDHVDELEPERHKESLP-----RFQAEL------EESHRHQLEALESPLCIQHEG 618 Query: 1127 HVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHL 1186 HV C ++ + E E + H EL + Q D Sbjct: 619 HVSD------------RCCVETSAL--GHEWRLEPSEGHSQELPWVHLQGVQD------- 657 Query: 1187 LIGKLQKAVSEECSYF-LQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDY 1245 G L+ L+T V LK E+ EN Y + L+D Sbjct: 658 --GDLEADTERAARVLGLETEHKVQLSLLQTELKEEIELLKIENRNLYGKLQHETRLKD- 714 Query: 1246 RYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFG---------EEN 1296 D ++ H L+ +E N Q+T+ MK EF +E Sbjct: 715 -----DLEKVKHNLIEDHQKELNNAK-----------QKTELMKQEFQRKETDWKVMKEE 758 Query: 1297 LPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEE-------QVQELESLISS 1349 L +E E L++ + L + + K + + +L + ++ + Q+ +LE ++ Sbjct: 759 LQREAEEKLTL--MLLELREKAESEKQTIINKFELREAEMRQLQDQQAAQILDLERSLTE 816 Query: 1350 LQQQLKETEQNYEAE--IHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGS-CV 1406 Q +L++ EQ+ ++ +HC Q E + ++ + E A + M S + Sbjct: 817 QQGRLQQLEQDLTSDDALHCSQ----CGREPPTAQDGELAALHVKEDCALQLMLARSRFL 872 Query: 1407 KKNIDGTIEFSGEFGV------KEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTE 1460 ++ + T +FS E ++ ++LL++++Q+QL + V+ + Q Sbjct: 873 EERKEITEKFSAEQDAFLQEAQEQHARELQLLQERHQQQL------LSVTAELEARHQAA 926 Query: 1461 LSRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKE 1520 L ++ E+ + A V + + + ++ + + + ++++ + EF+ + +E Sbjct: 927 LGELTASLESKQGALLAARVAELQTKHAADLGALETR-HLSSLDSLESCYLSEFQTIREE 985 Query: 1521 LGEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQL 1580 H + + L +D E+++ KD S+H I ++ ++ Sbjct: 986 ---HRQALELLRAD-------------FEEQLWKKD-------SLHQTILTQELEKLKRK 1022 Query: 1581 MLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQR 1640 +E +L+ +R L + T + Q E E + L E+ + L Q AQ Sbjct: 1023 --HEGELQSVRDHLRTEVSTELAGTVAHELQGVHQGEFGSEKKTALHEKEETLRLQSAQA 1080 Query: 1641 SSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQTF 1700 E E+E + L+ + Q+ + L +++ Q E Sbjct: 1081 QPFHQE----EKESLSLQLQKKNHQVQQLKDQVLSLSHEIEECRSELEVLQQRRERENRE 1136 Query: 1701 KEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRS 1760 L DV + +ER ALQ A RLL + E ++ + IG V LD + Sbjct: 1137 GANLLSMLKADV--NLSHSERGALQDALRRLLGLFGETLRAAVTLRSRIGERVGLCLDDA 1194 Query: 1761 SKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTE 1820 A ++ + E T +D ++P D ++ S V E Sbjct: 1195 G-------------AGLALSTAPALEETW-SDVALPEL---DRTLSECAEMSSVAE---- 1233 Query: 1821 LSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMR 1880 +S + S E E E+ + + L AV+ L+E ++S QLE A+ + + Sbjct: 1234 ISSHMRESFLMSPESVRECEQPIRRVFQSLSLAVDGLMEMALDSSRQLEEARQIHSRFEK 1293 Query: 1881 ESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQE 1940 E + +E + ++ +EL E L EES A+ +LA+EL K +G ++G+ E + + Sbjct: 1294 EFSFKNEETAQVVRKHQELLECLKEESAAKAELALELHKTQGTLEGFKVETADLKEVLAG 1353 Query: 1941 KTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEK 2000 K D RL EL +LQ+ EQ ++EE L + EA +A E L +E E Sbjct: 1354 KEDSEHRLVLELESLRRQLQQAAQEQAALREECTRLWSRGEATATDAEAREAALRKEVED 1413 Query: 2001 LMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEK 2060 L KE+ E + QAEK R L Q+K LE ++EEQ+S+ ++ + L QQ +L+K Sbjct: 1414 LTKEQSETRKQAEKDRSALLSQMKILESELEEQLSQHRGCAKQAEA-VTALEQQVASLDK 1472 Query: 2061 QLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTR------EVEQL 2114 L R+F+DEQA +REHER+ FQQEIQ+LE QL+ + QP ++ EVE L Sbjct: 1473 HLRNQRQFMDEQAAEREHEREEFQQEIQRLEGQLRQAAKPQPWGPRDSQQAPLDGEVELL 1532 Query: 2115 ANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFR---------------------V 2153 L+EK D+ +EL + KE R + + EEI++LE V Sbjct: 1533 QQKLREKLDEFNELAIQKESADRQVLMQEEEIKRLEEMNINIRKKVAQLQEEVEKQKNIV 1592 Query: 2154 RELEQALLVEDRKHFGAV-------------------EAKPELSLEVQLQAERDAIDRKE 2194 + LEQ V ++ ++ P E+QL+ + A+ R+E Sbjct: 1593 KGLEQDKEVLKKQQMSSLLLASTLQSTLDAGRCPEPPSGSPPEGPEIQLEVTQRALLRRE 1652 Query: 2195 KEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFK------D 2248 E+ +L+EQLE+ + +LE+KNEE+ L+++L++Q ++ L+ELE+EN K Sbjct: 1653 SEVLDLKEQLEKMKGDLESKNEEILHLNLKLDMQNSQTAVSLRELEEENTSLKVIYTRSS 1712 Query: 2249 DMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKI------ 2302 ++E+L I+ + Q +EK EI+QL+E + KLQ +L + Sbjct: 1713 EIEELKATIENLQENQKRLQ-----------KEKAEEIEQLHEVIEKLQHELSLMGPVVH 1761 Query: 2303 -TTDNKVIEEKNELI---------RDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQ 2352 +D++ ++EL+ + L+ ++E + +E + R ++ + ++ +E LQ Sbjct: 1762 EVSDSQAGSLQSELLCSQAGGPRGQALQGELEAALEAKEALSRLLADQERRHSQALEALQ 1821 Query: 2353 QELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETN 2412 Q L + + + L+ + + AE + +++ + + + E N Sbjct: 1822 QRLQGAEEAAEL-------QLAELERNVALREAEVEDMASRIQEFEAALKAKEATIAERN 1874 Query: 2413 FKMNQLTQELFSLKRERESV 2432 +++ L Q + E E+V Sbjct: 1875 LEIDALNQRKAAHSAELEAV 1894 Score = 307 bits (787), Expect = 1e-82 Identities = 290/1017 (28%), Positives = 496/1017 (48%), Gaps = 134/1017 (13%) Query: 2932 PKKIKGLLRAVHNEGMQVLSLTE--SPYSDGEDHSIQQVSEPWLEERKAYINTISSLKDL 2989 PK +K LL+ V +E Q+L+L+E +P S GE H ++ E ++D+ Sbjct: 2389 PKHVKALLQMVRDESHQILALSEGLAPPS-GEPHPPRKEDE---------------IQDI 2432 Query: 2990 ITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTALGTTDA 3049 +E + DWRG+LL +Q+ F +E+ + + L+ Sbjct: 2433 SLHGGKTQEVPT--------ACPDWRGDLLQVVQEAFEKEQEMQGVELQPRLSGSDLGGH 2484 Query: 3050 VGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQM------NGRKITLKR- 3102 LL LE+ I+EQG + ++E L+ DR SLLSEIQAL AQ+ N K+ R Sbjct: 2485 SSLLERLEKIIREQGDLQEKSLEHLRLPDRSSLLSEIQALRAQLRMTHLQNQEKLQHLRT 2544 Query: 3103 ----------EQESEKPSQ-ELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKM 3151 +QE + Q ELL Y ++Q++ ++Q LS +++A +Q+ L++E+ Sbjct: 2545 ALTSAEARGSQQEHQLRRQVELLAYKVEQEKCIAGDLQKTLSEEQEKANSVQKLLAAEQT 2604 Query: 3152 VVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRE 3211 VV +LKS+L +++ + E ++ + +E+ R + K +E+ L SEQ K R Sbjct: 2605 VVRDLKSDLCESRQKSEQLSRSLCEVQQEVLQLRSMLSSKENELKAALQELESEQGKGRA 2664 Query: 3212 LQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIES 3271 LQ LE+E+ + + E + + LE+L+ SLE+Q+ ++ +L + L+ ++ + Q+++ Sbjct: 2665 LQSQLEEEQLRHLQRESQSAKALEELRASLETQRAQSSRLCVALKHEQTAKDNLQKELRI 2724 Query: 3272 QRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPL 3331 + +A L++E+ + ELQ L +EK R E+S L ER L QL S T ++ Sbjct: 2725 EHSRCEALLAQERSQLSELQKDLAAEKSRTLELSEALRHERLLTEQL--SQRTQEACVHQ 2782 Query: 3332 PSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANT 3391 ++ LQK EEK SR+V+L EK + +L ++QQ+E + Q H + L+ E+E + Sbjct: 2783 DTQAHHALLQKLKEEK-SRVVDLQAMLEKVQQQALHSQQQLEAEAQKHCEALRREKEVSA 2841 Query: 3392 EGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELERE--EKRESR 3449 + + L ++ +L+ LE +R++ L E ++ ++E + ++ R E R+S Sbjct: 2842 TLKSTVEALHTQKRELRCSLEREREKPAWLQAELEQSHPRLKEQEGRKAARRSAEARQSP 2901 Query: 3450 RILYQNLNEPTTWSLTSDRTRNWVLQQ-----KIEG--------ETKESNYAKLIEM--- 3493 Q W ++ R LQ+ KI+ E+K+ + + Sbjct: 2902 AAAEQ----WRKWQRDKEKLRELELQRQRDLHKIKQLQQTVRDLESKDEVPGSRLHLGSA 2957 Query: 3494 -NGGGTGCNH------ELEMIRQKLQCVASKLQVLPQKASERL--QFETADDEDFIWVQE 3544 G+ +H ELE +RQ+L A L +A +R + +++++ + + Sbjct: 2958 RRAAGSDADHLREQQRELEAMRQRLLSAARLLTSFTSQAVDRTVNDWTSSNEKAVMSLLH 3017 Query: 3545 NIDEIILQLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNM 3604 ++E+ L + T Q + + + + LL+ N LT +S +T+EK +L Sbjct: 3018 TLEELKSDLSRPTSSQKKMAAELQ-----FQFVDVLLKDNVSLTKALSTVTQEKLELSRA 3072 Query: 3605 VMKLEEQIRWYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRAEAE 3664 V KLE+ ++ + Q G SE+ W ++ Q SL+R + Sbjct: 3073 VSKLEKLLKHHLQKGCSPSR-----------------SERSAWKPDETAPQSSLRRPDPG 3115 Query: 3665 VYKLKAELRNDSLLQTLSPDSEHVTLKRIYGKYLRAESFRKALIYQKKYLLLLLGGFQEC 3724 +L ++ + +V ++++Y YLRAESFRKALIYQKKYLLLL+GGFQ+ Sbjct: 3116 --RLPPAASEEA-------HTSNVKMEKLYLHYLRAESFRKALIYQKKYLLLLIGGFQDS 3166 Query: 3725 EDATLALLARMGGQPAFTDLEVITNRPKGFTRFRSAVRVSIAISRMKFLVRRWHRVTGSV 3784 E TL+++A +G P+ + + IT+RP FTRFR+AVRV IAI R++FLV++W V Sbjct: 3167 EQETLSMIAHLGVFPSKAERK-ITSRP--FTRFRTAVRVVIAILRLRFLVKKWQEV---- 3219 Query: 3785 SININRDGFGLNQGAEKTDSFYHSSGGLELYGEPRHTTYRSRSDLDYIRSPLPFQNR--- 3841 +R G L QG + PR D+ + P + R Sbjct: 3220 ----DRKG-ALAQGKAPRP----GPRARQPQSPPRTRESPPTRDVPSGHTRDPARGRRLA 3270 Query: 3842 -----YPGTPADFNPGS-LACSQLQNYDPDRALTDYITRLEALQRRLGTIQSGSTTQ 3892 + G A +P S L S + DP+ +LT+YI LE +Q+RLG + ST++ Sbjct: 3271 AAASPHSGGRATPSPNSRLERSLTASQDPEHSLTEYIHHLEVIQQRLGGVLPDSTSK 3327 Score = 146 bits (369), Expect = 3e-34 Identities = 379/1774 (21%), Positives = 703/1774 (39%), Gaps = 246/1774 (13%) Query: 1791 TDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGF---AGTEIDP-----ENEEL 1842 T E ++ SD P M++K E+ EL+ + SG AG E E L Sbjct: 191 TPEQRGIFTISDHPAEQRGMFTKECEQECELAITDLESGREDEAGLHQSQAVHGLELEAL 250 Query: 1843 MLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQ-EATESLKCQEELRE 1901 L++S+ A +E T + L+ K T +RE ++ + L+ +++ Sbjct: 251 RLSLSNMHTAQLEL-------TQANLQKEKETALTELREMLNSRRAQELALLQSRQQHEL 303 Query: 1902 RLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQEL-----LCAS 1956 L E ARE+ V L + A+ K + ++++ I+ L+++ LC Sbjct: 304 ELLREQHAREKEEVVLRCGQEA----AELKEKLQSEMEKNAQIVKTLKEDWESEKDLCLE 359 Query: 1957 NRLQELEAEQQQIQEE-RELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKV 2015 N +EL A+ Q E+ + ++ +AE + Q Q L + Q EK+ Sbjct: 360 NLRKELSAKHQSEMEDLQNQFQKELAEQRAELEKIFQDKNQAERALRNLESHHQAAIEKL 419 Query: 2016 RDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAID 2075 R+DLQ + D+E +F E E+EK EL +L+ + L+ Q ++ + L Q Sbjct: 420 REDLQSEHGRCLEDLE---FKFKESEKEKQLELENLQASYEDLKAQSQEEIRRLWSQLDS 476 Query: 2076 REHERDVFQQEIQKLEQQLKV-VPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQ 2134 R QE+ +L +QL R + + + + RE Q + L+ +L + E+ Sbjct: 477 ARTSR----QELSELHEQLLARTSRVEDLEQLKQREKTQHESELE-------QLRIYFEK 525 Query: 2135 LQRDIQER-NEEIEKLEFRVR-ELEQALL--VEDRKHFGAVEAKPELSLEVQLQAERDAI 2190 RD ++ E++ L+ R++ E ALL VE +E KPE + +D + Sbjct: 526 KLRDAEKTYQEDLTLLQQRLQGAREDALLDSVEVGLSCVGLEEKPE-------KGRKDHV 578 Query: 2191 DRKEKEITNLEEQLEQFREELENKN-EEVQQLHMQLEIQKK-----ESTTRLQELEQENK 2244 D E E +E L +F+ ELE + +++ L L IQ + L E + Sbjct: 579 DELEPE--RHKESLPRFQAELEESHRHQLEALESPLCIQHEGHVSDRCCVETSALGHEWR 636 Query: 2245 LFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQII-QEKEVEIDQLNEQVTKLQQQLKIT 2303 L + L + D + A+++ E E ++ Q++ LQ +LK Sbjct: 637 LEPSEGHSQELPWVHLQGVQDGDLEADTERAARVLGLETEHKV-----QLSLLQTELKEE 691 Query: 2304 TDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTS 2363 + IE +N L L+ + L D E VK N +IE Q+EL N QKT Sbjct: 692 IELLKIENRN-LYGKLQHETR-LKDDLEKVKHN----------LIEDHQKELNNAKQKTE 739 Query: 2364 MNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELF 2423 + + K V+ E+L E A E++T M L+E Q F Sbjct: 740 LMKQEFQRKETDWK-----VMKEELQRE-----AEEKLTLMLLELREKAESEKQTIINKF 789 Query: 2424 SLKR-ERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENG 2482 L+ E ++ Q+ + ++ +LE LT D ++G Sbjct: 790 ELREAEMRQLQDQQAAQILDLERSLTEQQGRLQQLEQDLTSDDALHCSQCGREPPTAQDG 849 Query: 2483 KGSIINLE----TRLLQLESTVSAKDLELTQCYKQ-----IKDMQEQGQFETEMLQKKIV 2533 + + ++++ +L+ S + E+T+ + +++ QEQ E ++LQ++ Sbjct: 850 ELAALHVKEDCALQLMLARSRFLEERKEITEKFSAEQDAFLQEAQEQHARELQLLQER-- 907 Query: 2534 NLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQ-----TISSEPERTNIQNLNQLREDE 2588 + Q+++ V A L ++ Q A+ E + Q +E + + +L L Sbjct: 908 HQQQLL--SVTAELEARHQ-AALGELTASLESKQGALLAARVAELQTKHAADLGALETRH 964 Query: 2589 LGSDISALTLRISELESQVVEMHTSLILEKEQVE--IAEKNVLEKEKKLLELQKLLEGNE 2646 L S S + +SE ++ E +L L + E + +K+ L + EL+KL +E Sbjct: 965 LSSLDSLESCYLSEFQTIREEHRQALELLRADFEEQLWKKDSLHQTILTQELEKLKRKHE 1024 Query: 2647 -KKQREKEKKRSPQDVEVLKTTT-EL-------FHSNEESGFFNELEALRAESVATKAEL 2697 + Q ++ R+ E+ T EL F S +++ + E LR +S + Sbjct: 1025 GELQSVRDHLRTEVSTELAGTVAHELQGVHQGEFGSEKKTALHEKEETLRLQSAQAQ--- 1081 Query: 2698 ASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKAC 2757 ++E+ E L +L K + L+ + + + E + +L +L++ E E +E Sbjct: 1082 PFHQEEKESLSLQLQKKNHQVQQLKDQVLSLSHEIEECRSELEVLQQRRERENREGANLL 1141 Query: 2758 MFEPLPIKLSKSIASQTDGTLK----------------ISSSNQTPQILVKNAGIQINLQ 2801 + LS S L+ S + + + +AG + L Sbjct: 1142 SMLKADVNLSHSERGALQDALRRLLGLFGETLRAAVTLRSRIGERVGLCLDDAGAGLALS 1201 Query: 2802 SECSSEEVTEIISQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLLKEEC- 2860 + + EE ++ + EL E ++E + RE ++ EC Sbjct: 1202 TAPALEETWSDVA--------LPELDRTLSECAEMSSVAEISSHMRESFLMSPESVRECE 1253 Query: 2861 GTLKAVIQCLRSKEGSSIPELAHSDAYQTREICSSDS--------GSDWGQGIYLTHSQG 2912 ++ V Q L S + E+A + Q E S ++ + H + Sbjct: 1254 QPIRRVFQSL-SLAVDGLMEMALDSSRQLEEARQIHSRFEKEFSFKNEETAQVVRKHQEL 1312 Query: 2913 FDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPW 2972 + E ++E A + K +G L E + + + +H + E Sbjct: 1313 LECLKEESAAKAELALEL--HKTQGTLEGFKVETADLKEVLAG--KEDSEHRLVLELESL 1368 Query: 2973 LEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLE---E 3029 + + ++L++ T++ + EA D+ + +L + + + Sbjct: 1369 RRQLQQAAQEQAALREECTRLWSRGEATATDAEAREAALRKEVEDLTKEQSETRKQAEKD 1428 Query: 3030 RSVLLAAFRTELTAL--------GTTDAVGLLNCLEQRI---------QEQGVEYQAAME 3072 RS LL+ + + L G + LEQ++ Q Q ++ QAA Sbjct: 1429 RSALLSQMKILESELEEQLSQHRGCAKQAEAVTALEQQVASLDKHLRNQRQFMDEQAAE- 1487 Query: 3073 CLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQ--------ELLEYNIQQKQSQ 3124 ++ +R EIQ L Q+ + K + + SQ ELL+ +++K + Sbjct: 1488 --REHEREEFQQEIQRLEGQL---RQAAKPQPWGPRDSQQAPLDGEVELLQQKLREKLDE 1542 Query: 3125 MLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAF 3184 E+ ++ S DR +QE+ E + E+ + + +L+ ++ Q +K LE Sbjct: 1543 FNELAIQKES-ADRQVLMQEE---EIKRLEEMNINIRKKVAQLQEEVEKQKNIVKGLEQD 1598 Query: 3185 RLEVKDKTDEVHLLNDTLASEQKKSR-------------ELQWALEKEKAKLGRSEERD- 3230 + +K + LL TL S R E+Q + + SE D Sbjct: 1599 KEVLKKQQMSSLLLASTLQSTLDAGRCPEPPSGSPPEGPEIQLEVTQRALLRRESEVLDL 1658 Query: 3231 KEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLEL 3290 KE+LE +K LES+ + L LNL L+ Q S +++E + N L Sbjct: 1659 KEQLEKMKGDLESKNEEILHLNLKLDMQNSQTAVSLRELEEE--------------NTSL 1704 Query: 3291 QVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSR 3350 +V+ + I E+ +T++ +E +LQ + + L E+ ++L+ + S Sbjct: 1705 KVIY-TRSSEIEELKATIENLQENQKRLQ--------KEKAEEIEQLHEVIEKLQHELSL 1755 Query: 3351 IVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQ 3410 + +++E + SLQ+ + + LQ E EA E ++ + L + Sbjct: 1756 MGPVVHEVSDSQAGSLQSELLCSQAGGPRGQALQGELEAALEAKEALSRLLA-------- 1807 Query: 3411 LEEKRQQVYKLDLEGQRLQGIMQ--EFQKQELER 3442 +++R+ L+ QRLQG + E Q ELER Sbjct: 1808 -DQERRHSQALEALQQRLQGAEEAAELQLAELER 1840 Score = 131 bits (329), Expect = 1e-29 Identities = 432/2144 (20%), Positives = 856/2144 (39%), Gaps = 331/2144 (15%) Query: 1 MEDEERQKKLEAGKAKLAQFRQRKAQSDGQSPSKKQKKKRKTSSSKHDVSAHHDLNIDQS 60 +E E+R++K+EAG+ KLA FR ++K K +S S+ + +D S Sbjct: 3 VEQEQRRRKVEAGRTKLAHFR-------------QRKTKGDSSHSEKKTAKRKGSAVDAS 49 Query: 61 QCNEMYINSSQRVESTVIPESTIMRTLHSGEITSHEQGFSVELESEISTTADDCSSEVNG 120 E + +S + I ++ + G + +DC E Sbjct: 50 VQEESPVTKE---DSALCGGGDICKSTSCDDTPDGAGG-------AFAAQPEDCDGEKRE 99 Query: 121 CSFVMRTGKPTNLLREE--EFGVDDSYSEQGAQ----DSPTHLEMM--ESELAGKQHEIE 172 ++ + + E+ F V D EQ D P M S+ +QH + Sbjct: 100 DLEQLQQKQVNDHPPEQCGMFTVSDHPPEQHGMFTVGDHPPEQRGMFTVSDHPPEQHGMF 159 Query: 173 ELNRELEEMRVTYGTEGLQQLQEFEAAIK----QRDGIITQLTANLQQARREKDETMREF 228 ++ E R + Q Q + ++ GI T +Q E +E Sbjct: 160 TVSDHPPEQRGMFTISDHQPEQRGMFTVSDHTPEQRGIFTISDHPAEQRGMFTKECEQEC 219 Query: 229 -LELT--EQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLE 285 L +T E ++ + Q QA L + +++ A+ ++ Q E++ L E Sbjct: 220 ELAITDLESGREDEAGLHQSQAVHGLELEALRLSLSNMHTAQLELTQANLQKEKETALTE 279 Query: 286 DYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKT 345 + +++ LQ + Q ++E ++ +EKE ++ + E ++K Sbjct: 280 LREMLNSRRAQELALLQSR-------QQHELELLREQHAREKEEVVLRCGQEAAELKEKL 332 Query: 346 LELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQ--SSEEIKQLMGTVEE 403 +K K L E E +K+ ++N++ EL+ Q E + ++ K+L E Sbjct: 333 QSEMEKNAQIVKTLKEDWES--EKDLCLENLRKELSAKHQSEMEDLQNQFQKELAEQRAE 390 Query: 404 LQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQM----------KQELI 453 L+K +Q E ++ +E Q +E+LR +L +G+ + + KQ + Sbjct: 391 LEKIFQDKNQAER-ALRNLESHHQAAIEKLREDLQSEHGRCLEDLEFKFKESEKEKQLEL 449 Query: 454 RQHMAQMEEMKTRHKGE-------MENALRSYSNITVNEDQIKLMNVAINELNIKLQDTN 506 A E++K + + E +++A S ++ +Q+ + +L Q Sbjct: 450 ENLQASYEDLKAQSQEEIRRLWSQLDSARTSRQELSELHEQLLARTSRVEDLEQLKQREK 509 Query: 507 SQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQ-----------TIAEQE 555 +Q E E+L + E+K L+ + E+L+ ++++Q AR+ + E Sbjct: 510 TQHESELEQLRIYFEKK--LRDAEKTYQEDLTLLQQRLQGAREDALLDSVEVGLSCVGLE 567 Query: 556 SKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLE-----KEKNAV 610 K + K V++L+ E S R + EL+ +++ +LE LE + + V Sbjct: 568 EKPEKGRK--DHVDELEPERHKESLPRFQAELEE-----SHRHQLEALESPLCIQHEGHV 620 Query: 611 LDRMAESQEAELERLRTQLLFSHEEELSKLK----EDLEIEHRINIEKLKDNLGI--HYK 664 DR A R + H +EL + +D ++E + E+ LG+ +K Sbjct: 621 SDRCCVETSALGHEWRLEPSEGHSQELPWVHLQGVQDGDLE--ADTERAARVLGLETEHK 678 Query: 665 QQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINEL 724 Q+ LQ E+ ++IE ++ E NL K + ++LKD + + ++ E+ ++N Sbjct: 679 VQLSLLQTELKEEIELLKIENRNLYGK----LQHETRLKDDLEKVKHNLIEDHQKELNNA 734 Query: 725 QKEIEILRQEEKEKGT----LEQEVQ-ELQLKTELLEKQMKEK-ENDLQ---EKFAQLEA 775 +++ E+++QE + K T +++E+Q E + K L+ +++EK E++ Q KF EA Sbjct: 735 KQKTELMKQEFQRKETDWKVMKEELQREAEEKLTLMLLELREKAESEKQTIINKFELREA 794 Query: 776 ENSILKDEKKTLEDMLKIHTPVSQEE-RLIFLD-----------SIKSKSKDSVWEKEIE 823 E L+D++ +L + +++++ RL L+ S + + + E+ Sbjct: 795 EMRQLQDQQAA--QILDLERSLTEQQGRLQQLEQDLTSDDALHCSQCGREPPTAQDGELA 852 Query: 824 ILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKN 883 L + + Q + + +E+++ + QE QE++A L++ L++ Sbjct: 853 ALHVKEDCALQLMLARSRFLEERKEITEKFSAEQDAFLQEAQEQHARELQL---LQERHQ 909 Query: 884 KQELEYKSKLKALNE----ELHLQRINPTTVKMKSSVFDEDKTFVA-----ETLEMGEVV 934 +Q L ++L+A ++ EL + + + V + A ET + + Sbjct: 910 QQLLSVTAELEARHQAALGELTASLESKQGALLAARVAELQTKHAADLGALETRHLSSLD 969 Query: 935 EKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHG-EISFLNEEVKSLKQEKEQVSLR 993 ++ L E + + + L +D EQL +K + L +E++ LK++ E Sbjct: 970 SLESCYLSEFQTIREEHRQALELLRADFEEQLWKKDSLHQTILTQELEKLKRKHE----- 1024 Query: 994 CRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDK 1053 EL+ + +H R T+VS+ L G V +G FG E K + +K Sbjct: 1025 -GELQSVRDHLR--------TEVSTELAGTVAHELQGVH------QGEFGSEKKTALHEK 1069 Query: 1054 VSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQM 1113 T+ +S Q Q ++ SL +N ++Q+ LK + L ++ Sbjct: 1070 ----EETLRLQSAQAQPFHQE-----EKESLSLQLQKKNHQVQQ----LKDQVLSLSHEI 1116 Query: 1114 EAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEK---IKELQKIHQLELQ 1170 E R L + + Q RE E L LK ++ + E+ L+++ L + Sbjct: 1117 EECRSELEV-----LQQRRERENREGANLLSMLKADVNLSHSERGALQDALRRLLGLFGE 1171 Query: 1171 TMKTQET-------------GDEGKPLHLLIGKLQKAVSEECS-YFLQTLCSVLGEYYTP 1216 T++ T D G L L A+ E S L L L E Sbjct: 1172 TLRAAVTLRSRIGERVGLCLDDAGAGLAL---STAPALEETWSDVALPELDRTLSECAEM 1228 Query: 1217 ALKCEVNAEDKEN---SGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVL 1273 + E+++ +E+ S + + E E P R Q + L+ + +L Sbjct: 1229 SSVAEISSHMRESFLMSPESVRECEQP----IRRVFQSLSLAVDGLMEMALDSSRQLEEA 1284 Query: 1274 QTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEK 1333 + S+ + EF +N +E + + H ++ LE + +K +L K Sbjct: 1285 RQIHSR--------FEKEFSFKN--EETAQVVRKHQEL--LECLKEESAAKAELALELHK 1332 Query: 1334 TKLEEQVQELESL-ISSLQQQLKETEQNYEAEIHCLQKRLQAVSESTVPPSLPVDSVVIT 1392 T+ + ++E+ + + +++E E+ L+++LQ ++ Sbjct: 1333 TQGTLEGFKVETADLKEVLAGKEDSEHRLVLELESLRRQLQQAAQ--------------- 1377 Query: 1393 ESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMS 1452 E A R + T + E +++E + + + ++Q E++ + ++ M Sbjct: 1378 EQAALREECTRLWSRGEATATDAEAREAALRKEVEDLTKEQSETRKQAEKDRSALLSQMK 1437 Query: 1453 IAFAQ-QTELSRISG-GKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKF 1510 I ++ + +LS+ G K+ A + V ++H N+ + +Q + E + F Sbjct: 1438 ILESELEEQLSQHRGCAKQAEAVTALEQQVASLDKHLRNQRQFMDEQAAEREHEREE--F 1495 Query: 1511 KEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEIS 1570 ++E + L +L + K D P + L + +++ K F +E++ Sbjct: 1496 QQEIQRLEGQLRQAAKPQPWGPRDSQQAPLDGEVEL-LQQKLREKLDEF-------NELA 1547 Query: 1571 VSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEI 1630 + A RQ+++ EE+++ + + + R+ QLQEE+ Sbjct: 1548 IQKESADRQVLMQEEEIKRLEEMNI----------------------NIRKKVAQLQEEV 1585 Query: 1631 KRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLSL-AGREKLCCELRNSSTQTQNGN 1689 ++ + + + D E L ++ LL L + Q +L AGR C E + S G Sbjct: 1586 EK-QKNIVKGLEQDKEVLKKQQMSSLL--LASTLQSTLDAGR---CPEPPSGS--PPEGP 1637 Query: 1690 ENQGEVEEQTFKEKE---LDRKPEDVPPEILSNERYALQKANNRL--LKILLEVVKTTAA 1744 E Q EV ++ +E LD K E L + L+ N + L + L++ + A Sbjct: 1638 EIQLEVTQRALLRRESEVLDLK------EQLEKMKGDLESKNEEILHLNLKLDMQNSQTA 1691 Query: 1745 VE----ETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPS--- 1797 V E + I RSS+ + E +A++++ + E R+ E Sbjct: 1692 VSLRELEEENTSLKVIYTRSSEIE---------ELKATIEN-LQENQKRLQKEKAEEIEQ 1741 Query: 1798 -YSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEI-DPENEELMLNISSRLQAAVE 1855 + + ++++++ V E ++ ++S ++ P + L + + L+A Sbjct: 1742 LHEVIEKLQHELSLMGPVVHEVSDSQAGSLQSELLCSQAGGPRGQALQGELEAALEAK-- 1799 Query: 1856 KLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAV 1915 EA+S + E E +++ + +EA E + E L E E +A Sbjct: 1800 ---EALSRLLADQERRHSQALEALQQRLQGAEEAAELQLAELERNVALREAE--VEDMAS 1854 Query: 1916 ELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEEREL 1975 + + E + A E T+ ER ++ ID L Q S ELEA + R Sbjct: 1855 RIQEFEAALK--AKEATIAERNLE-----IDALNQRKAAHS---AELEAVLLALARIRRA 1904 Query: 1976 LSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEV------QCQAE 2013 L +Q + A A P E Q L+ + +L+V +CQ E Sbjct: 1905 LEQQ--PLAAGAAPPELQWLRAQCARLSRQLQVLHQRFLRCQVE 1946 Score = 117 bits (294), Expect = 2e-25 Identities = 363/1784 (20%), Positives = 704/1784 (39%), Gaps = 270/1784 (15%) Query: 2039 ELEQEKNTELMDLRQ---------QNQALEK-QLEKMRKFLDEQAIDREHERDVFQQEIQ 2088 E EQE + DL Q+QA+ +LE +R L + ++ Q +Q Sbjct: 214 ECEQECELAITDLESGREDEAGLHQSQAVHGLELEALRLSLSNM---HTAQLELTQANLQ 270 Query: 2089 KLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEK 2148 K E++ + + ++ + +E+ L + + EL L +EQ R E+ E + + Sbjct: 271 K-EKETALTELREMLNSRRAQELALLQSRQQH------ELELLREQHAR---EKEEVVLR 320 Query: 2149 LEFRVRELEQALLVEDRKHFGAVEA-KPELSLEVQLQAERDAIDRKEKEITNLEEQLEQF 2207 EL++ L E K+ V+ K + E L E + K + +E+ QF Sbjct: 321 CGQEAAELKEKLQSEMEKNAQIVKTLKEDWESEKDLCLENLRKELSAKHQSEMEDLQNQF 380 Query: 2208 REELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQD 2267 ++EL + E++++ K ++ L+ LE ++ +EKL ++ +D Sbjct: 381 QKELAEQRAELEKIFQD----KNQAERALRNLESHHQAA---IEKLREDLQSEHGRCLED 433 Query: 2268 QHVLFGKFAQIIQEKEVEIDQLN-----------EQVTKLQQQL-KITTDNKVIEEKNEL 2315 L KF + +EK++E++ L E++ +L QL T + + E +E Sbjct: 434 ---LEFKFKESEKEKQLELENLQASYEDLKAQSQEEIRRLWSQLDSARTSRQELSELHEQ 490 Query: 2316 IRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQK--TSMNAHSLSEEA 2373 + +++E L ++ K E E+EQL EK ++ Q+ T + Sbjct: 491 LLARTSRVEDLEQLKQREKTQHESELEQLRIYFEKKLRDAEKTYQEDLTLLQQRLQGARE 550 Query: 2374 DSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVE 2433 D+L ++V ++ + LE++ E ++ +++L E R +ES+ Sbjct: 551 DALLDSVEVGLS-CVGLEEKPEKGRKD-------------HVDELEPE-----RHKESLP 591 Query: 2434 KIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRL 2493 + Q+ E S ++ L D + + E +G L Sbjct: 592 RFQAELEESHRHQLEALESPLCIQHEGHVSDRCCVETSALGHEWRLEPSEGHSQELPWVH 651 Query: 2494 LQLESTVSAKDLEL-TQCYKQIKDMQEQGQFETEMLQ---KKIVNLQKIVEEKVAAALVS 2549 LQ V DLE T+ ++ ++ + + + +LQ K+ + L KI + L Sbjct: 652 LQ---GVQDGDLEADTERAARVLGLETEHKVQLSLLQTELKEEIELLKIENRNLYGKLQH 708 Query: 2550 QIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVE 2609 + +L+ E K N + E N + +L + E + + EL+ + E Sbjct: 709 ETRLKDDLEKVKH---NLIEDHQKELNNAKQKTELMKQEFQRKETDWKVMKEELQREAEE 765 Query: 2610 MHTSLILE-KEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTT 2668 T ++LE +E+ E ++ ++ K E E + R+ + +++ Q +++ ++ T Sbjct: 766 KLTLMLLELREKAESEKQTIINK----------FELREAEMRQLQDQQAAQILDLERSLT 815 Query: 2669 ELFHSNEESGFFNELE-------ALRAESVATKAELASYKEKAEKLQEELLVKETNMTSL 2721 E + G +LE AL + A E A L VKE L Sbjct: 816 E------QQGRLQQLEQDLTSDDALHCSQCGREPPTAQDGELAA-----LHVKEDCALQL 864 Query: 2722 QKDLSQVRDHLAEAKEKLSILEKE--DETEVQESKKACMFEPLPIKLSKSIASQTDGTLK 2779 S+ + E EK S + E + Q +++ + + + S+ ++ + + Sbjct: 865 MLARSRFLEERKEITEKFSAEQDAFLQEAQEQHARELQLLQERHQQQLLSVTAELEARHQ 924 Query: 2780 ISSSNQTPQILVKNAGIQINLQSECSSEEVTEIISQFTEKIEKMQELHAAEILDMESRHI 2839 + T + K Q + V E+ ++ + ++ H + + +ES ++ Sbjct: 925 AALGELTASLESK--------QGALLAARVAELQTKHAADLGALETRHLSSLDSLESCYL 976 Query: 2840 SETETLKREHYVAVQLLK----EECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREICSS 2895 SE +T++ EH A++LL+ E+ ++ Q + ++E + + R+ + Sbjct: 977 SEFQTIREEHRQALELLRADFEEQLWKKDSLHQTILTQELEKLKRKHEGELQSVRDHLRT 1036 Query: 2896 DSGSDWGQGIYLTHSQGFDIASEGRGEESESATDSFPKKIK---GLLRAVHNEGMQVLSL 2952 + ++ G QG + G E ++A + ++ + H E + LSL Sbjct: 1037 EVSTELA-GTVAHELQG--VHQGEFGSEKKTALHEKEETLRLQSAQAQPFHQEEKESLSL 1093 Query: 2953 TESPYSDGEDHSIQQVSEPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFS 3012 ++H +QQ+ + L + + I + + +Q +RE E + + Sbjct: 1094 ----QLQKKNHQVQQLKDQVL----SLSHEIEECRSELEVLQQRRERENREGANLL---- 1141 Query: 3013 DWRGELLLALQQVFLEERSVLLAAFRTELTALGTT------------DAVGLLNCLEQRI 3060 +L A + ER L A R L G T + VGL CL+ Sbjct: 1142 ----SMLKADVNLSHSERGALQDALRRLLGLFGETLRAAVTLRSRIGERVGL--CLDDAG 1195 Query: 3061 QEQGVEYQAAME------CLQKADRR----SLLSEIQALHAQM-NGRKITLKREQESEKP 3109 + A+E L + DR + +S + + + M ++ + +E E+P Sbjct: 1196 AGLALSTAPALEETWSDVALPELDRTLSECAEMSSVAEISSHMRESFLMSPESVRECEQP 1255 Query: 3110 SQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELET 3169 + + + ++ ++EM ++ S + A ++ + E E +++ + EL Sbjct: 1256 IRRVFQ-SLSLAVDGLMEMALDSSRQLEEARQIHSRFEKEFSFKNEETAQVVRKHQELLE 1314 Query: 3170 TLKAQ-----------HKHLKELEAFRLEVKD-------KTDEVHLL---NDTLASEQKK 3208 LK + HK LE F++E D K D H L ++L + ++ Sbjct: 1315 CLKEESAAKAELALELHKTQGTLEGFKVETADLKEVLAGKEDSEHRLVLELESLRRQLQQ 1374 Query: 3209 SRELQWALEKEKAKL---GRSEERDKE--------ELEDL-KFSLESQKQRNLQLNLLLE 3256 + + Q AL +E +L G + D E E+EDL K E++KQ + LL Sbjct: 1375 AAQEQAALREECTRLWSRGEATATDAEAREAALRKEVEDLTKEQSETRKQAEKDRSALLS 1434 Query: 3257 QQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVL-----LESEKVRIREMSSTLDRE 3311 Q K L +E ++++ R E LE QV L +++ + E ++ + E Sbjct: 1435 QMKILESELEEQLSQHR---GCAKQAEAVTALEQQVASLDKHLRNQRQFMDEQAAEREHE 1491 Query: 3312 R-ELHAQLQSSDG----TGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSL 3366 R E ++Q +G + +P P + L ++E ++ E L+E + + Sbjct: 1492 REEFQQEIQRLEGQLRQAAKPQPWGPRDSQQAPLDGEVELLQQKLREKLDEFNELAI--- 1548 Query: 3367 QTRQQMEKDRQV--HRKTLQTEQEANTEGQKKMHELQSKVE---DLQRQLEE-----KRQ 3416 Q+ DRQV + ++ +E N +KK+ +LQ +VE ++ + LE+ K+Q Sbjct: 1549 ---QKESADRQVLMQEEEIKRLEEMNINIRKKVAQLQEEVEKQKNIVKGLEQDKEVLKKQ 1605 Query: 3417 QVYKLDLEGQRLQGIMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQ 3476 Q+ L L LQ + + E E I E T +L + L++ Sbjct: 1606 QMSSL-LLASTLQSTLDAGRCPEPPSGSPPEGPEIQL----EVTQRALLRRESEVLDLKE 1660 Query: 3477 KIE---GETKESNYAKL-----IEMNGGGTGCN-HELEMIRQKLQCV---ASKLQVLP-- 3522 ++E G+ + N L ++M T + ELE L+ + +S+++ L Sbjct: 1661 QLEKMKGDLESKNEEILHLNLKLDMQNSQTAVSLRELEEENTSLKVIYTRSSEIEELKAT 1720 Query: 3523 ----QKASERLQFETADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSPSTSCGSLTE 3578 Q+ +RLQ E A++ E + E+I +LQ G VS S GSL Sbjct: 1721 IENLQENQKRLQKEKAEE------IEQLHEVIEKLQHELSLMGPVVHEVSDS-QAGSLQS 1773 Query: 3579 RLLRQNA------ELTGHISQLTEEKNDLRNMVMKLE----EQIRWYRQTGAGRDNSSRF 3628 LL A L G + E K L ++ E + + +Q G + ++ Sbjct: 1774 ELLCSQAGGPRGQALQGELEAALEAKEALSRLLADQERRHSQALEALQQRLQGAEEAAEL 1833 Query: 3629 SLNGGANIEAIIASEKEVWNREKLTLQKSLKRAEAEVYKLKAEL 3672 L A+ +E E + +LK EA + + E+ Sbjct: 1834 QLAELERNVALREAEVEDMASRIQEFEAALKAKEATIAERNLEI 1877 Score = 102 bits (254), Expect = 7e-21 Identities = 351/1835 (19%), Positives = 719/1835 (39%), Gaps = 317/1835 (17%) Query: 1539 PESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQ--LMLNEEQ-LEDMRQELV 1595 PE + + TIS+ + F E++++ +++ R+ L++ Q + + E + Sbjct: 192 PEQRG-IFTISDHPAEQRGMFTKECEQECELAITDLESGREDEAGLHQSQAVHGLELEAL 250 Query: 1596 RQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERV 1655 R + +L + Q Q+E + L E + LN + AQ + L+ R++ Sbjct: 251 RLSLSNMHTAQL----ELTQANLQKEKETALTELREMLNSRRAQELA-----LLQSRQQ- 300 Query: 1656 LLEELEALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQTFK------EKELDRKP 1709 ELE L++ +E++ + + + +++ E Q K E E D Sbjct: 301 --HELELLREQHAREKEEVVLRCGQEAAELKEKLQSEMEKNAQIVKTLKEDWESEKDLCL 358 Query: 1710 EDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASL 1769 E++ E+ + + ++ N+ K E+ + A +E+ Sbjct: 359 ENLRKELSAKHQSEMEDLQNQFQK---ELAEQRAELEKIFQD------------------ 397 Query: 1770 IWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSG 1829 +++AE ++++ E H + E + R D+ +E + L Sbjct: 398 --KNQAERALRNL--ESHHQAAIEKL---------REDLQ---------SEHGRCLEDLE 435 Query: 1830 FAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTEL--MRESFRQKQ 1887 F E + E + + N+ + + + E I SQL+ A+ ++ EL + E + Sbjct: 436 FKFKESEKEKQLELENLQASYEDLKAQSQEEIRRLWSQLDSARTSRQELSELHEQLLART 495 Query: 1888 EATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTD--II 1945 E L+ Q + RE+ ES + K Y ++ TL ++++Q + ++ Sbjct: 496 SRVEDLE-QLKQREKTQHESELEQLRIYFEKKLRDAEKTYQEDLTLLQQRLQGAREDALL 554 Query: 1946 DRLEQELLCAS----------NRLQELEAEQQQ-----IQEERELLSR-QKEAMKA---- 1985 D +E L C + + ELE E+ + Q E E R Q EA+++ Sbjct: 555 DSVEVGLSCVGLEEKPEKGRKDHVDELEPERHKESLPRFQAELEESHRHQLEALESPLCI 614 Query: 1986 -EAGPVEQQLLQETEKLMKE-KLE-----------VQCQAEKVRD---DLQKQVKALEID 2029 G V + ET L E +LE V Q + D D ++ + L ++ Sbjct: 615 QHEGHVSDRCCVETSALGHEWRLEPSEGHSQELPWVHLQGVQDGDLEADTERAARVLGLE 674 Query: 2030 VEEQVS---------RFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDE----QAIDR 2076 E +V IEL + +N L Q L+ LEK++ L E + + Sbjct: 675 TEHKVQLSLLQTELKEEIELLKIENRNLYGKLQHETRLKDDLEKVKHNLIEDHQKELNNA 734 Query: 2077 EHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQ----LANHLKEKTDKCSELLLSK 2132 + + ++ +QE Q+ E KV+ E RE E+ + L+EK + + +++K Sbjct: 735 KQKTELMKQEFQRKETDWKVM------KEELQREAEEKLTLMLLELREKAESEKQTIINK 788 Query: 2133 EQLQ----RDIQERN--------EEIEKLEFRVRELEQALLVEDRKH------------- 2167 +L+ R +Q++ + + + R+++LEQ L +D H Sbjct: 789 FELREAEMRQLQDQQAAQILDLERSLTEQQGRLQQLEQDLTSDDALHCSQCGREPPTAQD 848 Query: 2168 --FGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQL 2225 A+ K + +L++ L R +RKE IT E+F E + +E Q+ H + Sbjct: 849 GELAALHVKEDCALQLMLARSRFLEERKE--IT------EKFSAEQDAFLQEAQEQHAR- 899 Query: 2226 EIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVE 2285 E+Q + + Q L +L LG + + ++ ++ +L + A++ + + Sbjct: 900 ELQLLQERHQQQLLSVTAELEARHQAALG---ELTASLESKQGALLAARVAELQTKHAAD 956 Query: 2286 IDQLNEQVTKLQQQLK--ITTDNKVIEEKN----ELIR-DLETQI--------ECLMSDQ 2330 + L + L+ ++ + I E++ EL+R D E Q+ L + Sbjct: 957 LGALETRHLSSLDSLESCYLSEFQTIREEHRQALELLRADFEEQLWKKDSLHQTILTQEL 1016 Query: 2331 ECVKRNREEEIEQLNEVIE-KLQQELANI----------GQKTSMNAHSLSEEADSLKHQ 2379 E +KR E E++ + + + ++ ELA G+ S +L E+ ++L+ Q Sbjct: 1017 EKLKRKHEGELQSVRDHLRTEVSTELAGTVAHELQGVHQGEFGSEKKTALHEKEETLRLQ 1076 Query: 2380 LDVVIA----EKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSL--KRERESVE 2433 EK +L Q++ N ++ +K+ + + ++ + EL L +RERE+ E Sbjct: 1077 SAQAQPFHQEEKESLSLQLQKKNHQVQQLKDQVLSLSHEIEECRSELEVLQQRRERENRE 1136 Query: 2434 KIQSIPENSVNVAIDHLSKDKPEL----------EVVLTEDALKSLENQTYFKSFEENGK 2483 + +V + H + + E + L+S + ++ G Sbjct: 1137 GANLLSMLKADVNLSHSERGALQDALRRLLGLFGETLRAAVTLRSRIGERVGLCLDDAGA 1196 Query: 2484 GSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKI----- 2538 G ++ L + S V+ +L+ T + +M + + M + +++ + + Sbjct: 1197 GLALSTAPALEETWSDVALPELDRT--LSECAEMSSVAEISSHMRESFLMSPESVRECEQ 1254 Query: 2539 ------------VEEKVAAALVSQIQLE-AVQEYAKFCQDNQTISSEPE---RTNIQNLN 2582 V+ + AL S QLE A Q +++F ++ + E R + + L Sbjct: 1255 PIRRVFQSLSLAVDGLMEMALDSSRQLEEARQIHSRFEKEFSFKNEETAQVVRKHQELLE 1314 Query: 2583 QLREDELGSDISALTLRISELESQVVEMHTSLILE----KEQVEIAEKNVLEKEKKLLEL 2638 L+E+ AL L ++ + ++ T+ + E KE E + VLE E +L Sbjct: 1315 CLKEESAAKAELALELHKTQGTLEGFKVETADLKEVLAGKEDSE--HRLVLELESLRRQL 1372 Query: 2639 QKLLE-------------------GNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGF 2679 Q+ + + + RE ++ +D+ ++ T + S Sbjct: 1373 QQAAQEQAALREECTRLWSRGEATATDAEAREAALRKEVEDLTKEQSETRKQAEKDRSAL 1432 Query: 2680 FNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKL 2739 ++++ L +E E S K E + E + SL K L R + E + Sbjct: 1433 LSQMKILESEL----EEQLSQHRGCAKQAEAVTALEQQVASLDKHLRNQRQFMDEQAAER 1488 Query: 2740 SILEKEDETEVQ--ESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQ 2797 +E + E+Q E + +P P S + DG +++ ++ N + Sbjct: 1489 EHEREEFQQEIQRLEGQLRQAAKPQPWGPRDSQQAPLDGEVELLQQKLREKLDEFN---E 1545 Query: 2798 INLQSECSSEEVTEIISQFTEKIEKMQELH------AAEILDMESRHISETETLKREHYV 2851 + +Q E + +V E+I++++E++ A++ + + + + L+++ V Sbjct: 1546 LAIQKESADRQVL----MQEEEIKRLEEMNINIRKKVAQLQEEVEKQKNIVKGLEQDKEV 1601 Query: 2852 AVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREICSSDSGSDWGQGIYLTHSQ 2911 L K++ +L + + PE + EI + + + S+ Sbjct: 1602 ---LKKQQMSSLLLASTLQSTLDAGRCPEPPSGSPPEGPEIQLEVTQ----RALLRRESE 1654 Query: 2912 GFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEP 2971 D+ + E+ + +S ++I L + + Q + + Sbjct: 1655 VLDLKEQL--EKMKGDLESKNEEILHLNLKLDMQNSQTAVSLRELEEENTSLKVIYTRSS 1712 Query: 2972 WLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERS 3031 +EE KA TI +L++ ++Q ++ E+ Q HE + EL L + V E Sbjct: 1713 EIEELKA---TIENLQENQKRLQKEKAEEI---EQLHEVIEKLQHELSL-MGPVVHEVSD 1765 Query: 3032 VLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHA 3091 + ++EL + A G R Q E +AA+E + R LL++ + H+ Sbjct: 1766 SQAGSLQSELLC---SQAGG------PRGQALQGELEAALEAKEALSR--LLADQERRHS 1814 Query: 3092 QMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKM 3151 Q L+ Q+ + ++E E + + + + + E+ M R E + L +++ Sbjct: 1815 Q------ALEALQQRLQGAEEAAELQLAELERNVALREAEVEDMASRIQEFEAALKAKEA 1868 Query: 3152 VVAELKSELAQTKLELETTLKAQHKHLKELEAFRL 3186 +AE LE++ + + H ELEA L Sbjct: 1869 TIAE-------RNLEIDALNQRKAAHSAELEAVLL 1896 Score = 92.8 bits (229), Expect = 6e-18 Identities = 130/623 (20%), Positives = 264/623 (42%), Gaps = 68/623 (10%) Query: 244 QLQASETLRNSTHSSTAADLLQAKQQI-LTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQ 302 Q ++ E LR SS +++ + Q+ +TH Q E+ HL + + Q L+ Sbjct: 2502 QEKSLEHLRLPDRSSLLSEIQALRAQLRMTHLQNQEKLQHLRTALTSAEARGSQQEHQLR 2561 Query: 303 EKIKV--YEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLG 360 ++++ Y++EQ+K + ++ + E++ + + E+ +LK L + + Sbjct: 2562 RQVELLAYKVEQEKCIAGDLQKTLSEEQEKANSVQKLLAAEQTVVRDLKSDLCESRQKSE 2621 Query: 361 ELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQ 420 +L + + QE+ ++ L++ + + + + +E++ G LQ SQ E + ++ Sbjct: 2622 QLSRSLCEVQQEVLQLRSMLSSKENELKAALQELESEQGKGRALQ------SQLEEEQLR 2675 Query: 421 RMEQETQ--RKLEQLRAELDEMYGQQ---IVQMKQE--------------------LIRQ 455 +++E+Q + LE+LRA L+ Q V +K E L+ Q Sbjct: 2676 HLQRESQSAKALEELRASLETQRAQSSRLCVALKHEQTAKDNLQKELRIEHSRCEALLAQ 2735 Query: 456 HMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQK---EKL 512 +Q+ E++ E L + + ++ E + QDT + +KL Sbjct: 2736 ERSQLSELQKDLAAEKSRTLELSEALRHERLLTEQLSQRTQEACVH-QDTQAHHALLQKL 2794 Query: 513 KEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSL-STVEDL 571 KEE +++ LQ LE + ++ S++Q++ Q E + E +L STVE L Sbjct: 2795 KEEKSRVVD----LQAMLEKVQQQALHSQQQLEAEAQKHCEALRREKEVSATLKSTVEAL 2850 Query: 572 ---KAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQ 628 K E+ + E +E +AE+ +L+ E K A A A E+ R Sbjct: 2851 HTQKRELRCSLEREREKPAWLQAELEQSHPRLKEQEGRKAARRSAEARQSPAAAEQWR-- 2908 Query: 629 LLFSHEEELSKLKEDLEIEHRINIEKLKD----NLGIHYKQQIDGLQNEMSQKIETMQFE 684 + + KL+E LE++ + ++ K+K + K ++ G + + + Sbjct: 2909 ---KWQRDKEKLRE-LELQRQRDLHKIKQLQQTVRDLESKDEVPGSRLHLGSARRAAGSD 2964 Query: 685 KDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQE 744 D+L +Q +L +L + L + S+ + +N+ EK +L Sbjct: 2965 ADHLREQQRELEAMRQRLLSAARLLTSFTSQAVDRTVNDWTS------SNEKAVMSLLHT 3018 Query: 745 VQELQLKTELLEKQMKEKENDLQEKFAQ--LEAENSILKDEKKTLEDMLKIHTPVSQEER 802 ++EL+ K+ +LQ +F L+ S+ K ++ L++ VS+ E+ Sbjct: 3019 LEELKSDLSRPTSSQKKMAAELQFQFVDVLLKDNVSLTKALSTVTQEKLELSRAVSKLEK 3078 Query: 803 LIFLDSIK----SKSKDSVWEKE 821 L+ K S+S+ S W+ + Sbjct: 3079 LLKHHLQKGCSPSRSERSAWKPD 3101 Score = 83.6 bits (205), Expect = 4e-15 Identities = 148/669 (22%), Positives = 283/669 (42%), Gaps = 100/669 (14%) Query: 324 IQEKETIIEELNTKIIEEEKKTLELKDK---LTTADKLLGELQEQIVQKNQEIKNMKLEL 380 ++ E II E + E+ + L L D+ L+ L +L+ +Q +++++++ L Sbjct: 2488 LERLEKIIREQGD-LQEKSLEHLRLPDRSSLLSEIQALRAQLRMTHLQNQEKLQHLRTAL 2546 Query: 381 TNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEM 440 T++ E + S++ QL VE L + ++ D+ + + +E Q K + Sbjct: 2547 TSA---EARGSQQEHQLRRQVELLAYKVEQEKCIAGDLQKTLSEE-QEKANSV------- 2595 Query: 441 YGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIK-LMNVAINELN 499 Q+++ +Q ++R + + E + + E RS + Q++ +++ NEL Sbjct: 2596 --QKLLAAEQTVVRDLKSDLCESRQKS----EQLSRSLCEVQQEVLQLRSMLSSKENELK 2649 Query: 500 IKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLN 559 LQ+ S++ K + ALQ QLE+ E+L + + Q A+ + S Sbjct: 2650 AALQELESEQGKGR-----------ALQSQLEE--EQLRHLQRESQSAKALEELRASLET 2696 Query: 560 EAHKSLSTVEDLKAEIVSASESRKELELKH---EAEVTNYKIKLEMLEKEKNAVLDRMAE 616 + +S LK E + +KEL ++H EA + + +L L+K+ A R E Sbjct: 2697 QRAQSSRLCVALKHEQTAKDNLQKELRIEHSRCEALLAQERSQLSELQKDLAAEKSRTLE 2756 Query: 617 SQEA-ELERLRTQLLFSHEEE-------------LSKLKEDLE--IEHRINIEKLKDNLG 660 EA ERL T+ L +E L KLKE+ ++ + +EK++ Sbjct: 2757 LSEALRHERLLTEQLSQRTQEACVHQDTQAHHALLQKLKEEKSRVVDLQAMLEKVQQQ-A 2815 Query: 661 IHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQ 720 +H +QQ++ E + E ++ EK+ T ++ + ++ ++L+ SL + + LQ Sbjct: 2816 LHSQQQLEA---EAQKHCEALRREKEVSATLKSTVEALHTQKRELRCSLEREREKPAWLQ 2872 Query: 721 INELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSIL 780 Q + QE ++ E ++ E K ++KE L+E Q + + + Sbjct: 2873 AELEQSHPRLKEQEGRKAARRSAEARQSPAAAEQWRKWQRDKEK-LRELELQRQRDLHKI 2931 Query: 781 KDEKKTLEDM-LKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQL 839 K ++T+ D+ K P S RL + ++ D+ +E + E E ++Q+ + Sbjct: 2932 KQLQQTVRDLESKDEVPGS---RLHLGSARRAAGSDADHLREQQ---RELEAMRQRLLSA 2985 Query: 840 NEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEE 899 R SF + + + +D S K + L+ L + Sbjct: 2986 ------ARLLTSFTSQAVD--------------RTVNDWTSSNEKAVMSLLHTLEELKSD 3025 Query: 900 LHLQRINPTTVKMKSSVFDEDKTFVAET-LEMGEVVEKDTTELMEKLEVTKREKLELSQR 958 L PT+ K AE + +V+ KD L + L +EKLELS+ Sbjct: 3026 LS----RPTS---------SQKKMAAELQFQFVDVLLKDNVSLTKALSTVTQEKLELSRA 3072 Query: 959 LSDLSEQLK 967 +S L + LK Sbjct: 3073 VSKLEKLLK 3081 Score = 74.3 bits (181), Expect = 2e-12 Identities = 101/432 (23%), Positives = 180/432 (41%), Gaps = 58/432 (13%) Query: 1838 ENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQE 1897 E ++ +L + S L + +L A+ E S+ + Q++L E R Q ++S K E Sbjct: 2629 EVQQEVLQLRSMLSSKENELKAALQELESEQGKGRALQSQLEEEQLRHLQRESQSAKALE 2688 Query: 1898 ELRERLHEESRAREQLAVELSKAEGVIDGYADEKTL----FERQIQEKTDIIDRLEQELL 1953 ELR L + +L V L + D E + E + ++ + L+++L Sbjct: 2689 ELRASLETQRAQSSRLCVALKHEQTAKDNLQKELRIEHSRCEALLAQERSQLSELQKDLA 2748 Query: 1954 CASNRLQEL-EAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQA 2012 +R EL EA + + +L R +EA + LLQ+ ++ +++Q Sbjct: 2749 AEKSRTLELSEALRHERLLTEQLSQRTQEACVHQDTQAHHALLQKLKEEKSRVVDLQAML 2808 Query: 2013 EKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQ 2072 EKV+ + LE + ++ L +EK L+ +AL Q ++R Sbjct: 2809 EKVQQQALHSQQQLEAEAQKHCE---ALRREKEVS-ATLKSTVEALHTQKRELR-----C 2859 Query: 2073 AIDREHERDVF-QQEIQK-----LEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCS 2126 +++RE E+ + Q E+++ EQ+ + R + EQ ++K +K Sbjct: 2860 SLEREREKPAWLQAELEQSHPRLKEQEGRKAARRSAEARQSPAAAEQWRKWQRDK-EKLR 2918 Query: 2127 ELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVE-DRKHFGAV------------EA 2173 EL L Q QRD+ +I++L+ VR+LE V R H G+ E Sbjct: 2919 ELEL---QRQRDL----HKIKQLQQTVRDLESKDEVPGSRLHLGSARRAAGSDADHLREQ 2971 Query: 2174 KPELSLEVQ--LQAER-------DAIDR--------KEKEITNLEEQLEQFREELENKNE 2216 + EL Q L A R A+DR EK + +L LE+ + +L Sbjct: 2972 QRELEAMRQRLLSAARLLTSFTSQAVDRTVNDWTSSNEKAVMSLLHTLEELKSDLSRPTS 3031 Query: 2217 EVQQLHMQLEIQ 2228 +++ +L+ Q Sbjct: 3032 SQKKMAAELQFQ 3043 Score = 72.4 bits (176), Expect = 8e-12 Identities = 131/691 (18%), Positives = 293/691 (42%), Gaps = 96/691 (13%) Query: 1813 KVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQ-LEHA 1871 +V +E E Q + G E+ P L S L +EK++ + + LEH Sbjct: 2455 QVVQEAFEKEQEM-----QGVELQPRLSGSDLGGHSSLLERLEKIIREQGDLQEKSLEHL 2509 Query: 1872 KVT-QTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADE 1930 ++ ++ L+ E ++L+ Q + ++E + A+ ++A G Sbjct: 2510 RLPDRSSLLSE--------IQALRAQLRMTHLQNQEKLQHLRTALTSAEARG-------- 2553 Query: 1931 KTLFERQIQEKTDIID-RLEQELLCASNRLQELEAEQQQIQEERELL------------- 1976 + E Q++ + +++ ++EQE A + + L EQ++ ++LL Sbjct: 2554 -SQQEHQLRRQVELLAYKVEQEKCIAGDLQKTLSEEQEKANSVQKLLAAEQTVVRDLKSD 2612 Query: 1977 ---SRQK-EAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEE 2032 SRQK E + V+Q++LQ L ++ E++ +++ + Q + +AL+ +EE Sbjct: 2613 LCESRQKSEQLSRSLCEVQQEVLQLRSMLSSKENELKAALQELESE-QGKGRALQSQLEE 2671 Query: 2033 QVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLE- 2091 + R ++ E + L +LR + Q ++ L + +++ + + E + E Sbjct: 2672 EQLRHLQRESQSAKALEELRASLETQRAQSSRLCVALKHEQTAKDNLQKELRIEHSRCEA 2731 Query: 2092 ------QQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSE----------------LL 2129 QL + + + +T E+ + H + T++ S+ LL Sbjct: 2732 LLAQERSQLSELQKDLAAEKSRTLELSEALRHERLLTEQLSQRTQEACVHQDTQAHHALL 2791 Query: 2130 LSKEQLQRDIQERNEEIEKLEFRVRELEQALLVEDRKHFGAVEAKPELSLEVQLQAERDA 2189 ++ + + + +EK++ + +Q L E +KH A+ + E+S L++ +A Sbjct: 2792 QKLKEEKSRVVDLQAMLEKVQQQALHSQQQLEAEAQKHCEALRREKEVS--ATLKSTVEA 2849 Query: 2190 IDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQK-KESTTRLQELEQ------E 2242 + +++E L LE+ RE+ E++Q H +L+ Q+ +++ R E Q + Sbjct: 2850 LHTQKRE---LRCSLEREREKPAWLQAELEQSHPRLKEQEGRKAARRSAEARQSPAAAEQ 2906 Query: 2243 NKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKI 2302 + ++ D EKL +E + +D H + + Q +++ E + + ++ + Sbjct: 2907 WRKWQRDKEKL----RELELQRQRDLHKI-KQLQQTVRDLESKDEVPGSRLHLGSARRAA 2961 Query: 2303 TTDNKVIEEKNELIRDLETQIECLMS--------DQECVKRNREEEIEQLNEVIEKLQQE 2354 +D + E+ R+LE + L+S + V R + + + L Sbjct: 2962 GSDADHLREQQ---RELEAMRQRLLSAARLLTSFTSQAVDRTVNDWTSSNEKAVMSLLHT 3018 Query: 2355 LANIGQKTSMNAHSLSEEADSLKHQ-LDVVIAEKLALEQQVETANEE-MTFMKNVLKETN 2412 L + S S + A L+ Q +DV++ + ++L + + T +E + + V K Sbjct: 3019 LEELKSDLSRPTSSQKKMAAELQFQFVDVLLKDNVSLTKALSTVTQEKLELSRAVSKLEK 3078 Query: 2413 FKMNQLTQELFSLKRERESVEKIQSIPENSV 2443 + L + + ER + + ++ P++S+ Sbjct: 3079 LLKHHLQKGCSPSRSERSAWKPDETAPQSSL 3109 Score = 60.5 bits (145), Expect = 3e-08 Identities = 152/738 (20%), Positives = 309/738 (41%), Gaps = 86/738 (11%) Query: 1958 RLQELEAEQQQIQEERELLSRQKEAMKAEAG----PVEQQLLQETEKLMKEKLEVQCQAE 2013 R + ++A Q +++E + E + +G P ++ +Q+ + EV Sbjct: 2388 RPKHVKALLQMVRDESHQILALSEGLAPPSGEPHPPRKEDEIQDISLHGGKTQEVPTACP 2447 Query: 2014 KVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQA 2073 R DL + V+ E +EQ + +EL+ + DL + LE+ + +R+ D Q Sbjct: 2448 DWRGDLLQVVQ--EAFEKEQEMQGVELQPRLSGS--DLGGHSSLLERLEKIIREQGDLQE 2503 Query: 2074 IDREH----ERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELL 2129 EH +R EIQ L QL++ +++ L L + S+ Sbjct: 2504 KSLEHLRLPDRSSLLSEIQALRAQLRMTHL------QNQEKLQHLRTALTSAEARGSQ-- 2555 Query: 2130 LSKEQLQRDIQERNEEIEKLEFRVRELEQALLVEDRKHFGAVEAKPELSLEVQLQAERDA 2189 + QL+R ++ ++E+ + +L++ L E K S++ L AE+ Sbjct: 2556 -QEHQLRRQVELLAYKVEQEKCIAGDLQKTLSEEQEK---------ANSVQKLLAAEQTV 2605 Query: 2190 IDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQE---NKLF 2246 + + ++ ++ EQ L +EV QL L ++ E LQELE E + Sbjct: 2606 VRDLKSDLCESRQKSEQLSRSLCEVQQEVLQLRSMLSSKENELKAALQELESEQGKGRAL 2665 Query: 2247 KDDMEKLGLAIKESDAMSTQDQHVLFGKF-AQIIQEKEVEIDQLNEQVTK--LQQQLKI- 2302 + +E+ L + ++ S + L Q Q + + +EQ K LQ++L+I Sbjct: 2666 QSQLEEEQLRHLQRESQSAKALEELRASLETQRAQSSRLCVALKHEQTAKDNLQKELRIE 2725 Query: 2303 --TTDNKVIEEK---NELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELAN 2357 + + +E+ +EL +DL + + E ++ R L E + + QE A Sbjct: 2726 HSRCEALLAQERSQLSELQKDLAAEKSRTLELSEALRHER-----LLTEQLSQRTQE-AC 2779 Query: 2358 IGQKTSMN---AHSLSEEAD---SLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKET 2411 + Q T + L EE L+ L+ V + L +QQ+E ++ KE Sbjct: 2780 VHQDTQAHHALLQKLKEEKSRVVDLQAMLEKVQQQALHSQQQLEAEAQKHCEALRREKEV 2839 Query: 2412 NFKMNQLTQELFSLKRE-RESVEKIQSIP---ENSVNVAIDHLSKDKPELEVVLTEDALK 2467 + + + L + KRE R S+E+ + P + + + L + + + +A + Sbjct: 2840 SATLKSTVEALHTQKRELRCSLEREREKPAWLQAELEQSHPRLKEQEGRKAARRSAEARQ 2899 Query: 2468 SLENQTYFKSFEENGKGSIINLET-------RLLQLESTV---SAKDLELTQCYKQIKDM 2517 S ++ ++ + K + LE ++ QL+ TV +KD E+ + Sbjct: 2900 SPAAAEQWRKWQRD-KEKLRELELQRQRDLHKIKQLQQTVRDLESKD-EVPGSRLHLGSA 2957 Query: 2518 QEQGQFETEMLQKKIVNLQKIVEEKVAAA-LVSQIQLEAVQEYAKFCQDNQTISSEPERT 2576 + + + L+++ L+ + + ++AA L++ +AV + D + + + + Sbjct: 2958 RRAAGSDADHLREQQRELEAMRQRLLSAARLLTSFTSQAVD---RTVNDWTSSNEKAVMS 3014 Query: 2577 NIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAE------KNVLE 2630 + L +L+ D L S+ +EL+ Q V+ +L K+ V + + + LE Sbjct: 3015 LLHTLEELKSD-LSRPTSSQKKMAAELQFQFVD-----VLLKDNVSLTKALSTVTQEKLE 3068 Query: 2631 KEKKLLELQKLLEGNEKK 2648 + + +L+KLL+ + +K Sbjct: 3069 LSRAVSKLEKLLKHHLQK 3086 Score = 56.6 bits (135), Expect = 5e-07 Identities = 126/618 (20%), Positives = 244/618 (39%), Gaps = 104/618 (16%) Query: 2 EDEERQKKLEAGKAKLAQFRQ---------RKAQSDGQSPSKKQKKKRKTSSSKH----D 48 E EE Q++++ + +L Q + ++A DG+ +QK + K Sbjct: 1491 EREEFQQEIQRLEGQLRQAAKPQPWGPRDSQQAPLDGEVELLQQKLREKLDEFNELAIQK 1550 Query: 49 VSAHHDLNIDQSQCN---EMYINSSQRV---ESTVIPESTIMRTLHSG-EITSHEQGFSV 101 SA + + + + EM IN ++V + V + I++ L E+ +Q S+ Sbjct: 1551 ESADRQVLMQEEEIKRLEEMNINIRKKVAQLQEEVEKQKNIVKGLEQDKEVLKKQQMSSL 1610 Query: 102 ELESEISTTAD-------DCSSEVNGCSFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSP 154 L S + +T D S G + + L RE E D Sbjct: 1611 LLASTLQSTLDAGRCPEPPSGSPPEGPEIQLEVTQRALLRRESE-----------VLDLK 1659 Query: 155 THLEMMESELAGKQHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIK---QRDGIITQLT 211 LE M+ +L K EI LN +L+ M+ + L++L+E ++K R I +L Sbjct: 1660 EQLEKMKGDLESKNEEILHLNLKLD-MQNSQTAVSLRELEEENTSLKVIYTRSSEIEELK 1718 Query: 212 A---NLQQ-ARREKDETMREFLELTEQSQKLQIQFQQL-----QASETLRNSTHSS---- 258 A NLQ+ +R + E E +L E +KLQ + + + S++ S S Sbjct: 1719 ATIENLQENQKRLQKEKAEEIEQLHEVIEKLQHELSLMGPVVHEVSDSQAGSLQSELLCS 1778 Query: 259 ---------------TAADLLQAKQQILTHQQQLEEQ--DHLLEDYQKKKEDFTMQISFL 301 A + +A ++L Q++ Q + L + Q +E +Q++ L Sbjct: 1779 QAGGPRGQALQGELEAALEAKEALSRLLADQERRHSQALEALQQRLQGAEEAAELQLAEL 1838 Query: 302 QEKIKVYEMEQDKKVENSNKEE--IQEKETIIEELNTKI--IEEEKK--TLELKDKLTTA 355 + + + E E + + E ++ KE I E N +I + + K + EL+ L Sbjct: 1839 ERNVALREAEVEDMASRIQEFEAALKAKEATIAERNLEIDALNQRKAAHSAELEAVLLAL 1898 Query: 356 DKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFE 415 ++ L++Q + ++ + RQ ++ + EL +R + + Sbjct: 1899 ARIRRALEQQPLAAGAAPPELQWLRAQCARLSRQLQVLHQRFLRCQVELDRRQARRATAH 1958 Query: 416 TDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENAL 475 T + Q M G Q+ ++ H A +E + +G+++ L Sbjct: 1959 TRVPGAHPQP-------------RMDGGAKAQVTGDVEASHDAALEPVVPDPQGDLQPVL 2005 Query: 476 RSYSN------------ITVNEDQIKLMNVAI-NELNIKLQDTNSQKEKLKEELGLILEE 522 + + +TV + Q++ + + NE+ + L+D KEK+ E+ L + Sbjct: 2006 VTLKDAPLCKQEGVMSVLTVCQRQLQSELLLVKNEMRLSLEDGGKGKEKVLEDCQLPKVD 2065 Query: 523 KCALQRQLEDLVEELSFS 540 A +QL++ + L +S Sbjct: 2066 LVAQVKQLQEKLNRLLYS 2083 Score = 47.8 bits (112), Expect = 2e-04 Identities = 85/449 (18%), Positives = 180/449 (40%), Gaps = 95/449 (21%) Query: 2463 EDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQ 2522 E ++ +E Q + G S++ ++++ + + K LE + + + E Sbjct: 2464 EQEMQGVELQPRLSGSDLGGHSSLLERLEKIIREQGDLQEKSLEHLRLPDRSSLLSEIQA 2523 Query: 2523 FETEMLQKKIVNLQKIVEEKVAAA------------LVSQIQLEAVQEYAKFC---QDNQ 2567 ++ + N +K+ + A L Q++L A + + C + Sbjct: 2524 LRAQLRMTHLQNQEKLQHLRTALTSAEARGSQQEHQLRRQVELLAYKVEQEKCIAGDLQK 2583 Query: 2568 TISSEPERTN-IQNL---NQLREDELGSDI-------SALTLRISELESQVVEMHTSLIL 2616 T+S E E+ N +Q L Q +L SD+ L+ + E++ +V+++ + L Sbjct: 2584 TLSEEQEKANSVQKLLAAEQTVVRDLKSDLCESRQKSEQLSRSLCEVQQEVLQLRSMLSS 2643 Query: 2617 EKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEE 2676 ++ +++ A + + ++ K LQ LE + + ++E + S + +E L+ + Sbjct: 2644 KENELKAALQELESEQGKGRALQSQLEEEQLRHLQRESQ-SAKALEELRAS--------- 2693 Query: 2677 SGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETN-----------MTSLQKDL 2725 LE RA+S L + + LQ+EL ++ + ++ LQKDL Sbjct: 2694 ------LETQRAQSSRLCVALKHEQTAKDNLQKELRIEHSRCEALLAQERSQLSELQKDL 2747 Query: 2726 SQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQ 2785 + + E E L E Q +++AC+ + + + Sbjct: 2748 AAEKSRTLELSEALRHERLLTEQLSQRTQEACVHQ------------------DTQAHHA 2789 Query: 2786 TPQILVKNAGIQINLQSECSSEEVTEIISQFTEKIEKMQELHAAEILDMESRHISETETL 2845 Q L + ++LQ+ EK+++ Q LH+ + L+ E++ E L Sbjct: 2790 LLQKLKEEKSRVVDLQA-------------MLEKVQQ-QALHSQQQLEAEAQ--KHCEAL 2833 Query: 2846 KREHYVAVQLLKEECGTLKAVIQCLRSKE 2874 +RE KE TLK+ ++ L +++ Sbjct: 2834 RRE--------KEVSATLKSTVEALHTQK 2854 Score = 42.7 bits (99), Expect = 0.007 Identities = 97/522 (18%), Positives = 198/522 (37%), Gaps = 90/522 (17%) Query: 1568 EISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQ 1627 E+ + L E +L+ QEL + + + L + +R ++R+ + + L+ Sbjct: 2629 EVQQEVLQLRSMLSSKENELKAALQELESEQGKGRALQSQLEEEQLRHLQRESQSAKALE 2688 Query: 1628 EEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQN 1687 E L Q AQ S +LC L++ T N Sbjct: 2689 ELRASLETQRAQSS-------------------------------RLCVALKHEQTAKDN 2717 Query: 1688 GNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEE 1747 +KEL R +L+ ER L + L K L T + E Sbjct: 2718 -------------LQKEL-RIEHSRCEALLAQERSQL----SELQKDLAAEKSRTLELSE 2759 Query: 1748 TIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRND 1807 + RH + ++ S+ A + ++A ++ + EE +RV D Sbjct: 2760 AL-RHERLLTEQLSQRTQEACVHQDTQAHHALLQKLKEEKSRVVDLQA------------ 2806 Query: 1808 INMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQA----------AVEKL 1857 M KV ++ Q+L E +E+ + S ++A ++E+ Sbjct: 2807 --MLEKVQQQALHSQQQLEAEAQKHCEALRREKEVSATLKSTVEALHTQKRELRCSLERE 2864 Query: 1858 LEAISETSSQLE--HAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAV 1915 E + ++LE H ++ + E R++ R+ EA +S E+ R+ ++ + RE + Sbjct: 2865 REKPAWLQAELEQSHPRLKEQE-GRKAARRSAEARQSPAAAEQWRKWQRDKEKLRE---L 2920 Query: 1916 ELSKAEGVIDGYADEKTLFERQIQEKTDIID---RLEQELLCASNRLQELEAEQQQIQEE 1972 EL + + ++T+ R ++ K ++ L A + L +Q++++ Sbjct: 2921 ELQRQRDLHKIKQLQQTV--RDLESKDEVPGSRLHLGSARRAAGSDADHLREQQRELEAM 2978 Query: 1973 RE-LLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVE 2031 R+ LLS + + V++ + T K + + E+++ DL + + + Sbjct: 2979 RQRLLSAARLLTSFTSQAVDRTVNDWTSSNEKAVMSLLHTLEELKSDLSRPTSSQKKMAA 3038 Query: 2032 EQVSRFIELEQEKNTE----LMDLRQQNQALEKQLEKMRKFL 2069 E +F+++ + N L + Q+ L + + K+ K L Sbjct: 3039 ELQFQFVDVLLKDNVSLTKALSTVTQEKLELSRAVSKLEKLL 3080 Score = 39.3 bits (90), Expect = 0.077 Identities = 59/279 (21%), Positives = 117/279 (41%), Gaps = 27/279 (9%) Query: 3086 IQALHAQMNGRKITLKREQESE--KPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQ 3143 ++ L + K+ R E E K + E L+ N ++ Q + E E+ + + +LQ Sbjct: 1694 LRELEEENTSLKVIYTRSSEIEELKATIENLQENQKRLQKEKAE---EIEQLHEVIEKLQ 1750 Query: 3144 EQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLA 3203 +LS VV E+ A + L++ L +A + E++ + L+ LA Sbjct: 1751 HELSLMGPVVHEVSDSQAGS---LQSELLCSQAGGPRGQALQGELEAALEAKEALSRLLA 1807 Query: 3204 SEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLN 3263 ++++ + ALE + +L +EE + +L +L +RN+ L E + + + Sbjct: 1808 DQERRHSQ---ALEALQQRLQGAEEAAELQLAEL--------ERNVALR---EAEVEDMA 1853 Query: 3264 ESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDG 3323 Q+ E+ +A ++E RNLE+ L + + E+ + L + L+ Sbjct: 1854 SRIQEFEAALKAKEATIAE---RNLEIDALNQRKAAHSAELEAVLLALARIRRALEQQPL 1910 Query: 3324 TGQSRPPLPS--EDLLKELQKQLEEKHSRIVELLNETEK 3360 + PP L +QL+ H R + E ++ Sbjct: 1911 AAGAAPPELQWLRAQCARLSRQLQVLHQRFLRCQVELDR 1949 >gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with transmembrane signal), 1 [Homo sapiens] Length = 3259 Score = 306 bits (783), Expect = 3e-82 Identities = 721/3512 (20%), Positives = 1452/3512 (41%), Gaps = 616/3512 (17%) Query: 1 MEDEERQKKLEAGKAKLAQFRQRKAQSDGQSPSKKQKKKRKTSSSKHDVSAHHDLNIDQS 60 ++D RQK ++ + A +RKA + K K + TS +K Sbjct: 64 LKDIIRQKDVQLQQKDEALQEERKAADNKIKKLKLHAKAKLTSLNK-------------- 109 Query: 61 QCNEMYINSSQRVESTVIPESTIMRTLHSGEITSHEQGFSVELESEISTTADDCSSEVNG 120 YI + TV+P S E S S E E EI + Sbjct: 110 -----YIEEMKAQGGTVLPTEP-----QSEEQLSKHDKSSTEEEMEIEKIKHKLQEK--- 156 Query: 121 CSFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLE---MMESELAGKQHEIEELNRE 177 L+ + + + +EQ AQ S T +E MM+ +L K+ I L + Sbjct: 157 ----------EELISTLQAQLTQAQAEQPAQSS-TEMEEFVMMKQQLQEKEEFISTLQAQ 205 Query: 178 LEEMRVTYGTEGLQQLQE--FEAAIKQRDGIITQLTAN-------------LQQARREKD 222 L + + + + + ++ FE ++ + + QL LQ+ E + Sbjct: 206 LSQTQAEQAAQQVVREKDARFETQVRLHEDELLQLVTQADVETEMQQKLRVLQRKLEEHE 265 Query: 223 ETMR------EFL--ELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQ 274 E++ + L ELT Q+ QI QQLQ E N+ ++ + ++K IL + Sbjct: 266 ESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESK--ILLEK 323 Query: 275 QQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEME-QDKKVENSNKEEIQEKETIIEE 333 +LE + L + ++E + F Q E+E + +E +K E++EK + I Sbjct: 324 MELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHILS 383 Query: 334 LNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEE 393 L E + LKD+ KLL + EQ VQ Q I+ ++ +L +Q S+E Sbjct: 384 LQKTGQELQSACDALKDQ---NSKLLQDKNEQAVQSAQTIQQLEDQL-------QQKSKE 433 Query: 394 IKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQEL- 452 I Q + + Q + F + + T+ + L+ + E+ ++ + + Sbjct: 434 ISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIE 493 Query: 453 IRQHMAQMEEMKTR-----HKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNS 507 + + A+ E++ ++ + A R S I++ + K + A L++T S Sbjct: 494 LEELKAENEKLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDVLENTFS 553 Query: 508 QKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSL-- 565 QK K EL ++L E +++ EE++F + Q+Q R A+ E + K + Sbjct: 554 QKHK---ELSVLLLE-------MKEAQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQMEG 603 Query: 566 STVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERL 625 + +K + V ++ ++ L + N + L +EKE+ + + S+E L Sbjct: 604 EGIAPIKMK-VFLEDTGQDFPL-----MPNEESSLPAVEKEQASTEHQSRTSEEISLNDA 657 Query: 626 RTQLLFS-----------------HEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQID 668 +L + H++EL +LK + +E +N K ++ Y++ +D Sbjct: 658 GVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQI-LELELNFHKAQE----IYEKNLD 712 Query: 669 GLQNEMS---QKIETMQFEKDN-------LITKQNQLILEISKLKDLQQSLVNSKSEEMT 718 E+S Q IE + DN L +++QL+ ++ +L + + K EM Sbjct: 713 EKAKEISNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQVKELSMVTELRAQVKQLEMN 772 Query: 719 LQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENS 778 L E Q+ ++ Q + L +++ L ++ + + +++ +N+L + Q +++ Sbjct: 773 LAEAERQRRLDYESQTAHD-NLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQST 831 Query: 779 ILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEI------LIEENEDL 832 +++ + L++ K + ER+ + S + ++ +KE+EI L+E+ D+ Sbjct: 832 LIRSLQSQLQN--KESEVLEGAERVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDV 889 Query: 833 K--QQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYK 890 + QQ I+ ++ + +FS EK ++N +E+++ +++K K++L Sbjct: 890 ETLQQTIEEKDQ-QVTEISFSMTEKMVQLN----EEKFSLGVEIK------TLKEQLNLL 938 Query: 891 SKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKR 950 S+ + +E ++ N + +K + +D EM + EL + ++ K+ Sbjct: 939 SRAEEAKKE-QVEEDNEVSSGLKQN-YD----------EMSPAGQISKEELQHEFDLLKK 986 Query: 951 EKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQE-KEQVSLRCREL-EIIINHNRAEN 1008 E + ++L K+ +S L EE+ +LK E K+++ L E E+ + E Sbjct: 987 ENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETERGEVEEDKENKEY 1046 Query: 1009 VQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQE 1068 + C T ++ + T E + + K +E+K++ E + Sbjct: 1047 SEKCVTSKCQEIEIYLKQTISEKEVELQHIRKD--------LEEKLAAEEQFQALVKQMN 1098 Query: 1069 QLILDHLPSVTKESSLRATQPSENDKLQKEL---NVLKSEQNDLRLQMEAQRICLSLVYS 1125 Q + D T + L + SEN + ++L N S+ + + L E ++V S Sbjct: 1099 QTLQDK----TNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKE------TVVIS 1148 Query: 1126 THVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLH 1185 E+ + E EE I A E++ ++LQK Q L + K Sbjct: 1149 PPCTGSSEHWKPE--------LEEKILALEKEKEQLQKKLQEALTSRKA----------- 1189 Query: 1186 LLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDP--ELQ 1243 + K E+ + + L +Y + + +++ EN GD + + + E Sbjct: 1190 -----ILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESI 1244 Query: 1244 DYRYEVQDFQEN------MHTLLNKVTEEYNKLLVLQTRLSKIW-GQQTDGMKLEFGEEN 1296 D + D QE+ + L K TE+++ VL++ L W D L+ G Sbjct: 1245 DGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQGG--- 1301 Query: 1297 LPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKE 1356 T I +Q+ +E V + K+SS E TK E+V +L+ I+ +++ Sbjct: 1302 -----TSVAQIKAQLKEIEAEKVELELKVSSTTS-ELTKKSEEVFQLQEQINKQGLEIES 1355 Query: 1357 TEQ-NYEAEIHC--LQKRLQAVSES--------TVPPSLPVDSVVITESDAQRTMYPGSC 1405 + ++EAE+H LQ++L++ + P L +I++ + + G Sbjct: 1356 LKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQL 1415 Query: 1406 VKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQL---EEEVAKVIVSMSIAFAQQTELS 1462 +K T + + E+ +++K L Q + Q +E + ++ V + + E+ Sbjct: 1416 SEKEAALT---KIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIG 1472 Query: 1463 RISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELG 1522 S K+ QA + ++E E K Q+++ + + L+K L Sbjct: 1473 EESRAKQQIQRKLQAALISRKEA--LKENKSLQEELSLA---------RGTIERLTKSLA 1521 Query: 1523 EHGKEILLSNSDPHDIPESKDCVL----TISEEMFSKDKTFI-VRQSIHDEISVSSMDAS 1577 + ++ N + KD VL + EE +DK + +S+ + S+SS S Sbjct: 1522 DVESQVSAQNKE-------KDTVLGRLALLQEE---RDKLITEMDRSLLENQSLSSSCES 1571 Query: 1578 RQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQL 1637 +L L E L + +++LV++ E L+ + + + +E ++LQ+E + L L Sbjct: 1572 LKLAL--EGLTEDKEKLVKE-------IESLKSSKIAESTEWQEKHKELQKEYEIL---L 1619 Query: 1638 AQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVEE 1697 ++ NE +ER + ++E + KQ + + Q Q + E++E Sbjct: 1620 QSYENVSNE---AERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKE 1676 Query: 1698 QTFK------------EKELDRKPEDV-PPEILSNERYALQKANNRLLKILLEVVKTTAA 1744 + K E+E DR +V P + E ++N +K LE VK Sbjct: 1677 KMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKME-- 1734 Query: 1745 VEETIGRHVLGIL-DRSSKSQSSASLIWRSEAEASVKSCV-----HEEHTRVTDESIPSY 1798 ET+ + ++ ++ S S+ L + E S ++ + H+ T VT+E S Sbjct: 1735 -YETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSI 1793 Query: 1799 SGSDMPRNDINMWSKVT----------------------EEGTELSQRL--VRSGFAGTE 1834 G ++ ++M ++ T +E Q++ ++ AG E Sbjct: 1794 PGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLE 1853 Query: 1835 IDPENEELMLNISSRLQAAVEKLLEAISETSSQLE--HAKVTQTELMRESFRQKQEATES 1892 E ++ S L+ LL IS +L+ +VT+ L+ + +++ Sbjct: 1854 ---EEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTK 1910 Query: 1893 LKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQEL 1952 LK E E+ E+L +L++ G I Y + T + QI+ + LE E+ Sbjct: 1911 LKETAE-----EEKDDLEERLMNQLAELNGSIGNYCQDVT--DAQIKN-----ELLESEM 1958 Query: 1953 LCASNRLQELEAEQQQIQEERELLSRQ--KEAMK----AEAGPVEQQLLQETEKLMKEKL 2006 + ELE E+QQ+ +E+ + + KE ++ A+ P + +E ++L+KEK Sbjct: 1959 KNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQ 2018 Query: 2007 EVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMR 2066 + Q +K Q+++ ALE V + F++ E +K DL + L + +E + Sbjct: 2019 QEVKQLQKDCIRYQEKISALERTV--KALEFVQTESQK-----DLEITKENLAQAVEHRK 2071 Query: 2067 KFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCS 2126 K E A KV+ + + Q+ LA++LK K Sbjct: 2072 KAQAELA-------------------SFKVL-----LDDTQSEAARVLADNLKLK----K 2103 Query: 2127 ELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVEDRKHFGAVEAKPELSLEVQLQAE 2186 EL +KE ++ +++++E++E R LEQA + KH L + +Q + Sbjct: 2104 ELQSNKESVKSQMKQKDEDLE------RRLEQA----EEKH---------LKEKKNMQEK 2144 Query: 2187 RDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLF 2246 DA+ R+EK +LEE + + + L K++EVQQL L+ + T+L + Sbjct: 2145 LDAL-RREK--VHLEETIGEIQVTLNKKDKEVQQLQENLD----STVTQLAAFTKSMSSL 2197 Query: 2247 KDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDN 2306 +DD +++ K+ + KF+ IQ KE EI + + L+ QL+ Sbjct: 2198 QDDRDRVIDEAKKWER-----------KFSDAIQSKEEEIRLKEDNCSVLKDQLR----- 2241 Query: 2307 KVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQ---QELANIGQKTS 2363 + + + +L+ I L D++ + + E++ +V + LQ +EL + ++T Sbjct: 2242 ----QMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETR 2297 Query: 2364 MNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKE-------TNFKMN 2416 HS E L+ +L + + L +E E+ ++ ++++ + F Sbjct: 2298 HLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYE 2357 Query: 2417 QLTQELFS-----------LKRERESVEKIQSIPENSVNVAIDHL----SKDKPELEVVL 2461 QL +L + + + + + + S E ++ VAI L K+ ELE +L Sbjct: 2358 QLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLL 2417 Query: 2462 TEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDL----ELTQCYKQIKDM 2517 +++ +++ + EEN K ++ +L++ T+ +++ +L K + + Sbjct: 2418 SQEEEENIVLE------EENKKA--VDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSL 2469 Query: 2518 QEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQL--EAVQEYAKFCQDNQTISSEPER 2575 Q + +IV + +EE+ + ++ + QL EA E K ++ + + S + Sbjct: 2470 QND--------RDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDD 2521 Query: 2576 TNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKL 2635 N +N + + A ++ E +QV+ + S + +V++ + LE + Sbjct: 2522 LNSEN----------AKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAK 2571 Query: 2636 LE--LQKLLEGNEKKQR-----EKEKKRSPQDVEVLKTT----TELFHSNEESG----FF 2680 LE L++ E NE +R ++EK+ +++E LK + T + +E G + Sbjct: 2572 LEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYH 2631 Query: 2681 NELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLS 2740 +L+ E A +S +++ +L+EEL+ + K + ++ D L K++L Sbjct: 2632 AQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAA---KKVGEIEDKL---KKELK 2685 Query: 2741 ILEKE-----DETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAG 2795 L + +ETE E + A +L++ + L ++ N+ +++ G Sbjct: 2686 HLHHDAGIMRNETETAEERVA--------ELARDLVEMEQKLLMVTKENKGLTAQIQSFG 2737 Query: 2796 IQI-NLQS--ECSSEEVTEIISQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVA 2852 + +LQ+ + ++EE+ E+ ++ ++++ +L +L+ E + L E + Sbjct: 2738 RSMSSLQNSRDHANEELDELKRKYDASLKELAQLKEQGLLN------RERDALLSETAFS 2791 Query: 2853 VQLLKE-ECGTLKAVIQCLRSKEGSSIPELAH-----SDAYQTREICSSDSGSDWGQGIY 2906 + +E L+ + Q L SK+ +L H D+Y + S S + + Sbjct: 2792 MNSTEENSLSHLEKLNQQLLSKD----EQLLHLSSQLEDSYNQVQSFSKAMASLQNERDH 2847 Query: 2907 LTHS-QGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSI 2965 L + + F + EG+ + S + + P +++ L +A+ S + D + Sbjct: 2848 LWNELEKFRKSEEGK-QRSAAQPSTSPAEVQSLKKAM------------SSLQNDRDRLL 2894 Query: 2966 QQVSEPWLEERKAYIN-TISSLKDLITKMQLQREA----EVYDSSQSHESFSDWRGELLL 3020 +++ L+++ IN I+ L L ++Q ++ ++ E+ S W+ E Sbjct: 2895 KELKN--LQQQYLQINQEITELHPLKAQLQEYQDKTKAFQIMQEELRQENLS-WQHE--- 2948 Query: 3021 ALQQVFLEERSVLLAAFR-TELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADR 3079 L Q+ +E+ S + R E + +D L+ L+ I+E Sbjct: 2949 -LHQLRMEKSSWEIHERRMKEQYLMAISDKDQQLSHLQNLIRE----------------L 2991 Query: 3080 RSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRA 3139 RS S+ Q L K+ +R+ E + N+ ++++L Q+ S + Sbjct: 2992 RSSSSQTQPL-------KVQYQRQASPETSASPDGSQNLVY-ETELLRTQLNDSLKEIHQ 3043 Query: 3140 TELQ-EQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLL 3198 EL+ +QL+S + E K+ L+ + +L+ +H +L + +L Sbjct: 3044 KELRIQQLNSNFSQLLEEKNTLSIQLCDTSQSLRENQQHYGDL----------LNHCAVL 3093 Query: 3199 NDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQ 3258 + Q + A + K G + D EEL + + S +Q+ + + Sbjct: 3094 EKQVQELQAGPLNIDVAPGAPQEKNGVHRKSDPEELREPQQSFSEAQQQLCNTRQEVNEL 3153 Query: 3259 KQLLNESQ-QKIESQRMLYDAQLSEEQGRNLE 3289 ++LL E + Q++ ++ L ++EEQ R LE Sbjct: 3154 RKLLEEERDQRVAAENAL---SVAEEQIRRLE 3182 Score = 298 bits (763), Expect = 7e-80 Identities = 684/3356 (20%), Positives = 1384/3356 (41%), Gaps = 510/3356 (15%) Query: 490 LMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQ 549 L NV ++EL+ + + L EL + + Q ED+ E L+++ + + + Sbjct: 8 LANVVLHELSGDDDTDQNMRAPLDPELHQESDMEFNNTTQ-EDVQERLAYAEQLVVELKD 66 Query: 550 TIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNA 609 I +++ +L + ++L E+ KA A K+L+L +A++T+ +E ++ + Sbjct: 67 IIRQKDVQLQQKDEALQ--EERKA----ADNKIKKLKLHAKAKLTSLNKYIEEMKAQGGT 120 Query: 610 VLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDG 669 VL +S+E L H++ S +E++EIE + + K+ L + Q+ Sbjct: 121 VLPTEPQSEEQ---------LSKHDK--SSTEEEMEIEKIKHKLQEKEELISTLQAQLTQ 169 Query: 670 LQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQI---NELQK 726 Q E + T E + + + QL + + LQ L +++E+ Q+ + + Sbjct: 170 AQAEQPAQSST---EMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAAQQVVREKDARF 226 Query: 727 EIEI-LRQEEKEKGTLEQEVQ-ELQLKTELLEKQMKEKENDL----------QEKFAQLE 774 E ++ L ++E + + +V+ E+Q K +L+++++E E L Q++ E Sbjct: 227 ETQVRLHEDELLQLVTQADVETEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAE 286 Query: 775 AENSILKDEKKTLE---DMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENED 831 N IL + + +E + L+ +EE I L+ ++ + V E+++ + Sbjct: 287 QRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELE----VAERKLSF-----HN 337 Query: 832 LKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKS 891 L+++ L E+ E+ A+ E Y L++++ ++ K S K E +S Sbjct: 338 LQEEMHHLLEQFEQAGQ----AQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQELQS 393 Query: 892 KLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKRE 951 AL ++ N ++ K+ + + + + + K+ ++ + +L + + E Sbjct: 394 ACDALKDQ------NSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHE 447 Query: 952 KLELSQRLSDLSEQLKQKHGE-ISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQ 1010 + +E + E I+ L + V L+ EK + L ELE + +AEN + Sbjct: 448 TASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIELEEL----KAEN-E 502 Query: 1011 SCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQL 1070 +Q++ L T + +S V+ + S + EN T ++ K+ + Sbjct: 503 KLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDVLEN-TFSQKHKELSV 561 Query: 1071 ILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRIC--LSLVYSTHV 1128 +L + +E + Q + + VL +Q +++ QME + I V+ Sbjct: 562 LLLEMKEAQEEIAFLKLQLQGKRAEEADHEVL--DQKEMK-QMEGEGIAPIKMKVFLEDT 618 Query: 1129 DQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLLI 1188 Q M NE+ KE+ + + E ++ ++ T++ GD+ I Sbjct: 619 GQDFPLMPNEESSLPAVEKEQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDI 678 Query: 1189 GKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYE 1248 G+ + E + L+ E+N + + + + E+ + Sbjct: 679 GQCHQDELERLK--------------SQILELELNFHKAQEIYEKNLDEKAKEISNLNQL 724 Query: 1249 VQDFQENMH---TLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFG---EENLPKEET 1302 +++F++N + ++EE ++LL LS + + +LE E + + Sbjct: 725 IEEFKKNADNNSSAFTALSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQRRLDY 784 Query: 1303 EFLSIHSQMTN--LEDIDVNHKSKLSSLQDLEKTKLEEQVQ--ELESLISSLQQQL--KE 1356 E + H + + + + KSK ++ L+ + Q+Q E +LI SLQ QL KE Sbjct: 785 ESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKE 844 Query: 1357 TEQNYEAE-IHCLQKRLQAVSESTVPPSLPVDSV----------------VITESDAQRT 1399 +E AE + + +++ +S++ L + + I E D Q T Sbjct: 845 SEVLEGAERVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVT 904 Query: 1400 MYPGSCVKKNIDGTIEFSGEFGV-----KEETNIVKLLEKQYQEQLEEEVAKVIVSMSIA 1454 S +K + E GV KE+ N++ E+ +EQ+EE+ Sbjct: 905 EISFSMTEKMVQLNEE-KFSLGVEIKTLKEQLNLLSRAEEAKKEQVEED----------- 952 Query: 1455 FAQQTELSRISGGKENTASSKQAHAVCQQE-QHYFNEMKLSQDQIGFQTFETVDVKFKEE 1513 E+S SG K+N A + ++E QH F+ +K +Q + + + KE Sbjct: 953 ----NEVS--SGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRK-RKLQAALINRKEL 1005 Query: 1514 FKPLSK---ELG----EHGKEILLSNSDPHDIPESKD-------CVLTISEEMFSKDKTF 1559 + +S+ EL E KEI LS ++ ++ E K+ CV + +E+ Sbjct: 1006 LQRVSRLEEELANLKDESKKEIPLSETERGEVEEDKENKEYSEKCVTSKCQEI-----EI 1060 Query: 1560 IVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQ 1619 ++Q+I ++ E +L+ +R++L + +Q L++Q M Q + Sbjct: 1061 YLKQTISEK---------------EVELQHIRKDLEEKLAAEEQFQALVKQ--MNQTLQD 1103 Query: 1620 REDQ-EQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCEL 1678 + +Q + LQ EI N+ + Q+ N + L++E + E EL Sbjct: 1104 KTNQIDLLQAEISE-NQAIIQKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPEL 1162 Query: 1679 RNSSTQTQNGNEN-QGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKAN-NRLLKILL 1736 + E Q +++E K + +K ++ + E QK + NRL + Sbjct: 1163 EEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHL--REELKQQKDDYNRLQEQFD 1220 Query: 1737 EVVKTTAAVEETIGR-------HVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTR 1789 E K + + + + + G L + + +S +S E + + HT+ Sbjct: 1221 EQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSST---PGLEEPLFKATEQHHTQ 1277 Query: 1790 VTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSR 1849 ES D P + + + + GT ++Q + EI+ E EL L +SS Sbjct: 1278 PVLESNLC---PDWPSHSED--ASALQGGTSVAQIKAQL----KEIEAEKVELELKVSS- 1327 Query: 1850 LQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRA 1909 T+S+L T+ E F+ +++ + E L+ HE Sbjct: 1328 --------------TTSEL-------TKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVH 1366 Query: 1910 REQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQI 1969 E L +L ++ I G + L + ++ E +I + E+++ S +L E EA +I Sbjct: 1367 AESLQQKLESSQLQIAGLEHLREL-QPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKI 1425 Query: 1970 QEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEID 2029 Q E + Q++ +KA +E Q + E++ + ++E+ C+ ++ +++ ++ +A Sbjct: 1426 QTE---IIEQEDLIKALHTQLEMQAKEHDERIKQLQVEL-CEMKQKPEEIGEESRA---- 1477 Query: 2030 VEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQK 2089 ++Q+ R ++ E + ++N++L+++L R ++ + DV Q + Sbjct: 1478 -KQQIQRKLQAALISRKEAL---KENKSLQEELSLARGTIERLT---KSLADVESQVSAQ 1530 Query: 2090 LEQQLKVVPRFQPISEHQTREVEQLANHLKEK---TDKCSELLLSKEQLQRDIQERNEEI 2146 +++ V+ R + E + + + ++ L E + C L L+ E L D ++ +EI Sbjct: 1531 NKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEI 1590 Query: 2147 EKLEFRVRELEQALLVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQ 2206 E L K E+ +LQ E + + + + ++N E+++ Sbjct: 1591 ESL----------------KSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQH 1634 Query: 2207 FREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQ 2266 E + + +E+ E KKE+ +LQE EQE + K+ M K A S Q Sbjct: 1635 VVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKF--------AKSKQ 1686 Query: 2267 DQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLK-----ITTDNKVIEEKNELIR---- 2317 Q I E E E D+L +V K + + N ++E+ E ++ Sbjct: 1687 ----------QKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYE 1736 Query: 2318 DLETQIECLMSDQECVKRNREEEIEQLNEVIE------------KLQQELANIGQKTSMN 2365 L + + LMS+++ + EE++ L IE + N+ ++ + + Sbjct: 1737 TLSKKFQSLMSEKDSLS----EEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQS 1792 Query: 2366 AHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSL 2425 +EE DSL +E + + A + + + +++QL + + L Sbjct: 1793 IPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGL 1852 Query: 2426 KRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQ---------TYFK 2476 + E++ ++ EN N + +S EL+++ E +L NQ T K Sbjct: 1853 EEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLK 1912 Query: 2477 SFEENGKGSIIN-LETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNL 2535 E K + L +L +L ++ ++T Q + E+L+ ++ NL Sbjct: 1913 ETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDA-----------QIKNELLESEMKNL 1961 Query: 2536 QKIVEE--KVAAALVSQ---IQLEAVQEYAKFCQD------NQTISSEPE---RTNIQNL 2581 +K V E + LV + ++ E +EY + Q N++ + E + + Q + Sbjct: 1962 KKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEV 2021 Query: 2582 NQLRED--ELGSDISALTLRISELESQVVEMHTSLILEKE------------QVEIAEKN 2627 QL++D ISAL + LE E L + KE Q E+A Sbjct: 2022 KQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFK 2081 Query: 2628 VLEKEKKL---------LELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESG 2678 VL + + L+L+K L+ N K+ + + K+ +D+E E H E+ Sbjct: 2082 VLLDDTQSEAARVLADNLKLKKELQSN-KESVKSQMKQKDEDLERRLEQAEEKHLKEKKN 2140 Query: 2679 FFNELEALRAESVATKAELASYK-------EKAEKLQEELLVKET-------NMTSLQKD 2724 +L+ALR E V + + + ++ ++LQE L T +M+SLQ D Sbjct: 2141 MQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDD 2200 Query: 2725 LSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSN 2784 +V D + + K S + E E++ + C L +L + + + IS Sbjct: 2201 RDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSV--LKDQLRQMSIHMEELKINISRLE 2258 Query: 2785 QTPQILVKNAGIQINLQSECSSE---EVTEIISQFTEKIEKMQELHAAEILDMESRHISE 2841 QI A ++ LQ + E E++SQ E+ + E+ +ES S Sbjct: 2259 HDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQL-EETRHLYHSSQNELAKLESELKSL 2317 Query: 2842 TETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREICSSDSGSDW 2901 + L + +++ KE+ G L+ +I R +E + +T S + S Sbjct: 2318 KDQLT-DLSNSLEKCKEQKGNLEGII---RQQEADIQNSKFSYEQLETDLQASRELTSRL 2373 Query: 2902 GQGIYLTHSQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGE 2961 + I + + + S G+ E + A LR H++ ++ L E+ S E Sbjct: 2374 HEEINMKEQKIISLLS-GKEEAIQVAIAE--------LRQQHDKEIKEL---ENLLSQEE 2421 Query: 2962 DHSI--QQVSEPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELL 3019 + +I ++ ++ +++ + T+ ++K K +Q++A++ +S S + R ++ Sbjct: 2422 EENIVLEEENKKAVDKTNQLMETLKTIK----KENIQQKAQLDSFVKSMSSLQNDRDRIV 2477 Query: 3020 LALQQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADR 3079 QQ LEER + + + +L + +++E+ ++ M+ L ++ Sbjct: 2478 GDYQQ--LEERHLSIILEKDQLIQEAAAE--------NNKLKEEIRGLRSHMDDLN-SEN 2526 Query: 3080 RSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQK---QSQMLEMQVELSSMK 3136 L +E+ +N + IT+K Q+ ++LLE +QQ +++ +++ +L + Sbjct: 2527 AKLDAELIQYREDLN-QVITIKDSQQ-----KQLLEVQLQQNKELENKYAKLEEKLKESE 2580 Query: 3137 DRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKE---LEAFRLEVKDKTD 3193 + +L+ ++ + +L E+ K+ + + L Q L+E L + ++K K + Sbjct: 2581 EANEDLRRSFNALQEEKQDLSKEIESLKVSI-SQLTRQVTALQEEGTLGLYHAQLKVKEE 2639 Query: 3194 EVHLLNDTLASEQKKSRELQWAL---EKEKAK-LGRSEERDKEELEDL-------KFSLE 3242 EVH L+ +S QK+ EL+ L +KE AK +G E++ K+EL+ L + E Sbjct: 2640 EVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETE 2699 Query: 3243 SQKQRNLQL--NLLLEQQKQLLNESQQK-IESQRMLYDAQLSEEQGR----NLELQVLLE 3295 + ++R +L +L+ +QK L+ + K + +Q + +S Q N EL L Sbjct: 2700 TAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKR 2759 Query: 3296 SEKVRIREMSST-----LDRERE--LHAQLQSSDGTGQS---------RPPLPSEDLLKE 3339 ++E++ L+RER+ L S + T ++ + L ++ L Sbjct: 2760 KYDASLKELAQLKEQGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQLLH 2819 Query: 3340 LQKQLEEKHSRIVE--------------LLNETEKYKLDSLQTRQQMEKDRQVHRKTLQT 3385 L QLE+ ++++ L NE EK++ S + +Q+ +Q+ Sbjct: 2820 LSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFR-KSEEGKQRSAAQPSTSPAEVQS 2878 Query: 3386 EQEANTEGQKKMHELQSKVEDLQRQLEEKRQQV---YKLDLEGQRLQGIMQEFQ-KQELE 3441 ++A + Q L ++++LQ+Q + Q++ + L + Q Q + FQ QE Sbjct: 2879 LKKAMSSLQNDRDRLLKELKNLQQQYLQINQEITELHPLKAQLQEYQDKTKAFQIMQEEL 2938 Query: 3442 REEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCN 3501 R+E + L+Q E ++W + R + L + + + S+ LI Sbjct: 2939 RQENLSWQHELHQLRMEKSSWEIHERRMKEQYLMAISDKDQQLSHLQNLI---------- 2988 Query: 3502 HELEMIRQKLQCVASKLQVLPQKASERLQFETADDEDFIWVQENIDEIILQLQKLTGQQG 3561 ++L+ +S+ Q L + + ET+ D ++ + + L Q Sbjct: 2989 -------RELRSSSSQTQPLKVQYQRQASPETSASPD------GSQNLVYETELLRTQLN 3035 Query: 3562 EEPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKLEEQIRWYRQ 3617 + S + ++ LR +L + SQL EEKN L + + +R +Q Sbjct: 3036 D---------SLKEIHQKELRIQ-QLNSNFSQLLEEKNTLSIQLCDTSQSLRENQQ 3081 Score = 277 bits (708), Expect = 2e-73 Identities = 700/3474 (20%), Positives = 1400/3474 (40%), Gaps = 598/3474 (17%) Query: 409 HKDSQFE-TDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQE---LIRQHMA---QME 461 H++S E + Q QE EQL EL ++ Q+ VQ++Q+ L + A +++ Sbjct: 35 HQESDMEFNNTTQEDVQERLAYAEQLVVELKDIIRQKDVQLQQKDEALQEERKAADNKIK 94 Query: 462 EMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLK-EELGLIL 520 ++K K ++ +L Y + L +E + D +S +E+++ E++ L Sbjct: 95 KLKLHAKAKL-TSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKL 153 Query: 521 EEK----CALQRQLEDLVEEL----SFSREQIQRARQTIAEQESKLN--EAHKSLSTVED 570 +EK LQ QL E S E+ +Q + E+E ++ +A S + E Sbjct: 154 QEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQ 213 Query: 571 LKAEIVSASESRKELELK-HEAE----VTNYKIKLEMLEKEKNAVLDRMAESQEAELERL 625 ++V ++R E +++ HE E VT ++ EM +K + VL R E E L Sbjct: 214 AAQQVVREKDARFETQVRLHEDELLQLVTQADVETEMQQKLR--VLQRKLEEHEESLVG- 270 Query: 626 RTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEK 685 R Q++ ++EL+ ++ +I L L QQ++ N + +ET + E Sbjct: 271 RAQVVDLLQQELTAAEQRNQI--------LSQQL-----QQMEAEHNTLRNTVETEREES 317 Query: 686 DNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEV 745 L+ K LE+++ K L + LQ+E+ L ++ ++ G + E+ Sbjct: 318 KILLEKME---LEVAERK---------------LSFHNLQEEMHHLLEQFEQAGQAQAEL 359 Query: 746 QELQLKTELLEK-QMKEKEN---DLQEKFAQLEAENSILKDEK-KTLEDMLKIHTPVSQE 800 + E K +M+EK + LQ+ +L++ LKD+ K L+D + Sbjct: 360 ESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSACDALKDQNSKLLQD---------KN 410 Query: 801 ERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVN 860 E+ + + +D + +K EI ++ L + +Q +E + SF + E Sbjct: 411 EQAVQSAQTIQQLEDQLQQKSKEI----SQFLNRLPLQQHETASQT----SFPDVYNEGT 462 Query: 861 YQELQEEYACLLKVKDDLEDSK-----NKQELEYKSKLKALNEELHLQRINPTTVKMKSS 915 +E A L K +LE+ K + ELE +LKA NE+L Q T ++ ++ Sbjct: 463 QAVTEENIASLQKRVVELENEKGALLLSSIELE---ELKAENEKLSSQI---TLLEAQNR 516 Query: 916 VFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISF 975 + D+ EV E ++ K + E + L QKH E+S Sbjct: 517 TGEADR----------EVSEISIVDIANKRSSSAEESGQ-----DVLENTFSQKHKELSV 561 Query: 976 LNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSV 1035 L E +K+ +E+++ L++ + RAE +LD G + Sbjct: 562 LLLE---MKEAQEEIAF----LKLQLQGKRAEEADH------EVLDQKEMKQMEGEGIAP 608 Query: 1036 SKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKE--SSLRATQPSEND 1093 K+ K+ +ED + EES LP+V KE S+ ++ SE Sbjct: 609 IKM--------KVFLEDTGQDFPLMPNEESS--------LPAVEKEQASTEHQSRTSEEI 652 Query: 1094 KLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFA 1153 L LKS + D + A + + H D++ + L K + I+ Sbjct: 653 SLNDAGVELKSTKQDGDKSLSA----VPDIGQCHQDELERLKSQILELELNFHKAQEIYE 708 Query: 1154 Q--EEKIKELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTL--CSV 1209 + +EK KE+ ++QL + K + A+SEE L + S+ Sbjct: 709 KNLDEKAKEISNLNQLIEEFKKNADNNSSAFT----------ALSEERDQLLSQVKELSM 758 Query: 1210 LGEYYTPALKCEVNAEDKENSG--DYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEY 1267 + E + E+N + E DY S+ L E +H+L + + Sbjct: 759 VTELRAQVKQLEMNLAEAERQRRLDYESQTAHDNL---------LTEQIHSLSIEAKSKD 809 Query: 1268 NKLLVLQTRLSKIWGQQTDGMKLEFGEEN---------LPKEETEFLSIHSQMTNLEDID 1318 K+ VLQ L D ++L+F E++ L +E+E L ++ ++ Sbjct: 810 VKIEVLQNEL--------DDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISS-K 860 Query: 1319 VNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSES 1378 V S+ S ++LE TK+++ + E + + +LQQ ++E +Q + +++ ++E Sbjct: 861 VEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEE 920 Query: 1379 TVPPSLPVDSVVITES-------------DAQRTMYPGSCVKKNIDGTIEFSGEFGVKEE 1425 SL V+ + E + S +K+N D + +G+ +E Sbjct: 921 KF--SLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYD-EMSPAGQISKEEL 977 Query: 1426 TNIVKLLEKQYQEQ--------------------LEEEVAKVI-VSMSIAFAQQTELSRI 1464 + LL+K+ +++ LEEE+A + S +TE + Sbjct: 978 QHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETERGEV 1037 Query: 1465 SGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFE-------TVDVKFKEEFKPL 1517 KEN S++ QE + + +S+ ++ Q + +F+ K + Sbjct: 1038 EEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQM 1097 Query: 1518 SKELGEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDAS 1577 ++ L + +I L ++ + ++T + + D +V++++ + Sbjct: 1098 NQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKETVVISPPCTGSSEH 1157 Query: 1578 RQLMLNEE--QLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNR 1635 + L E+ LE +++L ++ QE + + + + + RE+ +Q +++ RL Sbjct: 1158 WKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQE 1217 Query: 1636 QLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNENQGEV 1695 Q ++S +NEN+ + L+QL + RE + +L ST Q + + Sbjct: 1218 QFDEQSK-ENENIGDQ-----------LRQLQIQVRESIDGKL--PSTDQQESCSSTPGL 1263 Query: 1696 EEQTFKEKELDRKPEDVPPEILSN--ERYALQKANNRLLKILLEVVKTTAAVEETIGRHV 1753 EE FK E P + SN + + L+ V + A ++E V Sbjct: 1264 EEPLFKATE----QHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKV 1319 Query: 1754 LGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSK 1813 L SS +++ L +SE ++ ++++ + ES+ + S ++ + ++ Sbjct: 1320 ELELKVSS---TTSELTKKSEEVFQLQEQINKQGLEI--ESLKTVS------HEAEVHAE 1368 Query: 1814 VTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKV 1873 ++ E SQ + E+ P+ +EL Q + K E +S S QL + Sbjct: 1369 SLQQKLESSQLQIAGLEHLRELQPKLDEL--------QKLISKKEEDVSYLSGQLSEKEA 1420 Query: 1874 TQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTL 1933 T++ E Q ++ ++L Q E++ + H+E +QL VEL + + + +E Sbjct: 1421 ALTKIQTEIIEQ-EDLIKALHTQLEMQAKEHDERI--KQLQVELCEMKQKPEEIGEESRA 1477 Query: 1934 FERQIQEKTD--IIDR---------LEQELLCASNRLQELEAEQQQIQEERELLSRQKEA 1982 ++QIQ K +I R L++EL A ++ L ++ + +++K+ Sbjct: 1478 -KQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDT 1536 Query: 1983 MKAEAGPVEQQ---LLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIE 2039 + ++++ L+ E ++ + E + E L+ ++ L D E+ V Sbjct: 1537 VLGRLALLQEERDKLITEMDRSLLENQSLSSSCES----LKLALEGLTEDKEKLVKEIES 1592 Query: 2040 LEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDRE---HERDVFQQEIQKLEQQLKV 2096 L+ K E + +++++ L+K+ E + + + + + E H + +QE Q+L +L+ Sbjct: 1593 LKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRS 1652 Query: 2097 VPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNE----EIEKLEFR 2152 + +E Q +E EQ +KEK K ++ SK+Q +++E N+ E+ Sbjct: 1653 TEANKKETEKQLQEAEQEMEEMKEKMRKFAK---SKQQKILELEEENDRLRAEVHPAGDT 1709 Query: 2153 VRELEQALLVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELE 2212 +E + LL + + ++ ++R + E L ++ + E + Sbjct: 1710 AKECMETLLSSNA-------------------SMKEELERVKMEYETLSKKFQSLMSEKD 1750 Query: 2213 NKNEEVQQLHMQLE--IQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMS-----T 2265 + +EEVQ L Q+E + K+ + ++ + + + ++ + + +E D++S T Sbjct: 1751 SLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPT 1810 Query: 2266 QDQHVLFGKFAQIIQEKEV-----------EIDQLNEQVTKLQQQLKITTD-NKVIE-EK 2312 + V K A K+ +IDQL E++ L+++ + + ++ +E EK Sbjct: 1811 CSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEK 1870 Query: 2313 NELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEE 2372 N L+ + T+ D E + +EE+ ++N + +++Q+EL+ + + + EE Sbjct: 1871 NTLLSQISTK------DGEL--KMLQEEVTKMNLLNQQIQEELSRVTKLKE----TAEEE 1918 Query: 2373 ADSLKHQLDVVIAE---------KLALEQQV--ETANEEMTFMKNVLKETNFKMNQLTQE 2421 D L+ +L +AE + + Q+ E EM +K + E + QL +E Sbjct: 1919 KDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKE 1978 Query: 2422 LFSLKRE--RESVEKIQSIPENSVNVA----IDHLSKDKPELEVVLTEDALKSLENQTYF 2475 ++ E +E +EKIQ + N + + L K+K + L +D ++ E Sbjct: 1979 KTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQE----- 2033 Query: 2476 KSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNL 2535 K S + + L+ T S KDLE+T+ NL Sbjct: 2034 -------KISALERTVKALEFVQTESQKDLEITK-----------------------ENL 2063 Query: 2536 QKIVE--EKVAAALVS-QIQLEAVQ-EYAKFCQDNQTISSEPERTNIQNLNQLREDELGS 2591 + VE +K A L S ++ L+ Q E A+ DN + E + +Q+++ + Sbjct: 2064 AQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKD--- 2120 Query: 2592 DISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQRE 2651 L R+ + E + ++ ++ +E+++ + + E+ + E+Q L KK +E Sbjct: 2121 --EDLERRLEQAEEKHLKEKKNM---QEKLDALRREKVHLEETIGEIQVTLN---KKDKE 2172 Query: 2652 KEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEK----AEKL 2707 ++ + D T T+L + F + +L+ + E ++ K + Sbjct: 2173 VQQLQENLD----STVTQL------AAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSK 2222 Query: 2708 QEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDE-------TEVQESKKAC--- 2757 +EE+ +KE N + L+ L Q+ H+ E K +S LE + + TEVQ +K C Sbjct: 2223 EEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTL 2282 Query: 2758 ------MFEPLP-------------IKLSKSIASQTDGTLKISSS---------NQTPQI 2789 + L KL + S D +S+S N I Sbjct: 2283 QGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGII 2342 Query: 2790 LVKNAGIQINL----QSECSSEEVTEIISQFTEKI--------------EKMQELHAAEI 2831 + A IQ + Q E + E+ S+ E+I E+ ++ AE+ Sbjct: 2343 RQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAEL 2402 Query: 2832 LDMESRHISETETL----KREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAY 2887 + I E E L + E+ V + K+ +++ L++ + +I + A D++ Sbjct: 2403 RQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSF 2462 Query: 2888 QTREICSSDSGSDWGQGIYLTHSQ---GFDIASEGRGEESESATDSFPKKIKGLLRAVHN 2944 + + S + D G Y + + + +E+ + + ++I+GL + + Sbjct: 2463 -VKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDD 2521 Query: 2945 EGMQVLSLTESPYSDGED---------HSIQQVSEPWLEERKAYINTISSLKDLITKMQL 2995 + L ED +Q+ E L++ K N + L++ + + + Sbjct: 2522 LNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEE 2581 Query: 2996 QREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTALGTTDAVGL--- 3052 E D +S + + + +L ++ + V ++ ++TAL +GL Sbjct: 2582 ANE----DLRRSFNALQEEKQDLSKEIESL-----KVSISQLTRQVTALQEEGTLGLYHA 2632 Query: 3053 -----------LNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLK 3101 L+ L Q++ E + + C+QK + ++ + ++ L Sbjct: 2633 QLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAK----KVGEIEDKLKKELKHLH 2688 Query: 3102 REQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELA 3161 + + E E + + ++EM+ +L + L Q+ S ++ L++ Sbjct: 2689 HDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRD 2748 Query: 3162 QTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKA 3221 EL+ + LKEL + + + LL++T S LEK Sbjct: 2749 HANEELDELKRKYDASLKELAQLKEQGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQ 2808 Query: 3222 KLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLS 3281 +L +E+ L+ S + + + L ++ L NE ++ +S+ Sbjct: 2809 QLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFRKSE--------- 2859 Query: 3282 EEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQ 3341 E + R+ +E +++ S+L +R + LLKEL Sbjct: 2860 EGKQRSAAQPSTSPAEVQSLKKAMSSLQNDR---------------------DRLLKEL- 2897 Query: 3342 KQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQ 3401 K L++++ +I + + E K LQ Q K Q+ ++ L+ E N Q ++H+L Sbjct: 2898 KNLQQQYLQINQEITELHPLKA-QLQEYQDKTKAFQIMQEELRQE---NLSWQHELHQL- 2952 Query: 3402 SKVEDLQRQLEEKRQQVYKL------DLEGQRLQGIMQEFQKQELEREEKRESRRILYQN 3455 ++E ++ E+R + L D + LQ +++E + + + ++ YQ Sbjct: 2953 -RMEKSSWEIHERRMKEQYLMAISDKDQQLSHLQNLIRELRSS----SSQTQPLKVQYQR 3007 Query: 3456 LNEPTTWSLTSDRTRNWV-----LQQKIEGETKESNYAKL--IEMNGGGTGCNHELEMIR 3508 P T S + D ++N V L+ ++ KE + +L ++N + E + Sbjct: 3008 QASPET-SASPDGSQNLVYETELLRTQLNDSLKEIHQKELRIQQLNSNFSQLLEEKNTLS 3066 Query: 3509 QKLQCVASKLQVLPQKASERLQFETADDEDFIWVQE---NIDEIILQLQKLTG--QQGEE 3563 +L + L+ Q + L ++ +Q NID Q+ G ++ + Sbjct: 3067 IQLCDTSQSLRENQQHYGDLLNHCAVLEKQVQELQAGPLNIDVAPGAPQEKNGVHRKSDP 3126 Query: 3564 PSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLR----NMVMKLEEQIR 3613 L P S ++L E+ + +L EE+ D R N + EEQIR Sbjct: 3127 EELREPQQSFSEAQQQLCNTRQEV-NELRKLLEEERDQRVAAENALSVAEEQIR 3179 Score = 227 bits (578), Expect = 2e-58 Identities = 599/2999 (19%), Positives = 1240/2999 (41%), Gaps = 397/2999 (13%) Query: 932 EVVEKDTTELMEKLEVTKREKLELSQRLS-DLSEQLKQKHGEISFLNEEVKSLKQEKEQV 990 E+ ++ E + +E+L +++L +L + ++QK + L ++ ++L++E++ Sbjct: 33 ELHQESDMEFNNTTQEDVQERLAYAEQLVVELKDIIRQKDVQ---LQQKDEALQEERKAA 89 Query: 991 SLRCRELEIIINHNRAENVQSCDTQVSSLL--DGVVTMTSRGAEGSVSKVNKSFGEESKI 1048 + ++L++ H +A+ + S + + + G V T +E +SK +KS EE Sbjct: 90 DNKIKKLKL---HAKAK-LTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEME 145 Query: 1049 MVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQND 1108 + + K + ++E+LI +T+ +A QP+++ +E ++K + + Sbjct: 146 IEKIKHKLQ--------EKEELISTLQAQLTQA---QAEQPAQSSTEMEEFVMMKQQLQE 194 Query: 1109 LRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLE 1168 + + LS T +Q + + EKD E + E+++ LQ + Q + Sbjct: 195 KEEFISTLQAQLS---QTQAEQAAQQVVREKDARF----ETQVRLHEDEL--LQLVTQAD 245 Query: 1169 LQTMKTQETGDEGKPLH----LLIGKLQ---------KAVSEECSYFLQTLCSVLGEYYT 1215 ++T Q+ + L L+G+ Q A + Q L + E+ T Sbjct: 246 VETEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNT 305 Query: 1216 PALKCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQT 1275 L+ V E +E+ + E + E+ + + + QE MH LL + + L++ Sbjct: 306 --LRNTVETEREESK--ILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELES 361 Query: 1276 RLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTK 1335 R S + +Q ++E ++ + + S L+D SKL LQD K Sbjct: 362 RYSAL--EQKHKAEMEEKTSHILSLQKTGQELQSACDALKD----QNSKL--LQD----K 409 Query: 1336 LEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRL-----QAVSESTVPPSLPVDSVV 1390 E+ VQ +++ QQL++ Q EI RL + S+++ P + Sbjct: 410 NEQAVQSAQTI-----QQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQA 464 Query: 1391 ITESDAQRTMYPGSCVKKNIDGTIEFSG----EFGVKEE--TNIVKLLEKQYQE-QLEEE 1443 +TE + ++ +N G + S E + E ++ + LLE Q + + + E Sbjct: 465 VTEENIA-SLQKRVVELENEKGALLLSSIELEELKAENEKLSSQITLLEAQNRTGEADRE 523 Query: 1444 VAKVIVSMSIAFAQQTELSRISGGK---ENTASSKQAHAVCQQEQHYFNEMKLSQDQIGF 1500 V+++ + + A + S G+ ENT S K ++ EMK +Q++I F Sbjct: 524 VSEISI---VDIANKRSSSAEESGQDVLENTFSQKH-----KELSVLLLEMKEAQEEIAF 575 Query: 1501 QTFETVDVKFKE---------EFKPLSKE----------LGEHGKEILLSNSDPHDIPE- 1540 + + +E E K + E L + G++ L ++ +P Sbjct: 576 LKLQLQGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAV 635 Query: 1541 -----SKDCVLTISEEMFSKDKTFIVRQSIHD-EISVSSMDASRQLMLNEEQLEDMRQEL 1594 S + SEE+ D ++ + D + S+S++ Q ++++LE ++ ++ Sbjct: 636 EKEQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQC--HQDELERLKSQI 693 Query: 1595 VRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRL---NRQLAQRSSIDNENLVSE 1651 + +A E+ + ++ + ++ + QL EE K+ N S + + L+S+ Sbjct: 694 LELELNFHKAQEIYEK-NLDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQ 752 Query: 1652 -RERVLLEELEA-LKQL--SLAGREKLCCELRNSSTQTQNGNENQGEVEEQTFKEKELDR 1707 +E ++ EL A +KQL +LA E+ R ++Q ++N + + ++ Sbjct: 753 VKELSMVTELRAQVKQLEMNLAEAERQ----RRLDYESQTAHDN---LLTEQIHSLSIEA 805 Query: 1708 KPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSA 1767 K +DV E+L NE +Q + ++ + E + + SSK + + Sbjct: 806 KSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEELS 865 Query: 1768 SLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVR 1827 + + E E + + E R + + D +I+ +TE+ +L++ Sbjct: 866 QALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISF--SMTEKMVQLNEEKFS 923 Query: 1828 SGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEH--------AKVTQTELM 1879 G EI E+L N+ SR + A ++ +E +E SS L+ ++++ EL Sbjct: 924 ---LGVEIKTLKEQL--NLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQ 978 Query: 1880 RE-SFRQKQEATESLKCQEEL---RERLHEESRAREQLA---------VELSKAE-GVID 1925 E +K+ K Q L +E L SR E+LA + LS+ E G ++ Sbjct: 979 HEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETERGEVE 1038 Query: 1926 GYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKA 1985 + K E+ + K I+ + + E E E Q I+++ E +E +A Sbjct: 1039 EDKENKEYSEKCVTSKCQEIE------IYLKQTISEKEVELQHIRKDLEEKLAAEEQFQA 1092 Query: 1986 EAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEID----VEEQVSRFIELE 2041 + Q L +T ++ + E+ ++ + A + D V+E V Sbjct: 1093 LVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKETVVISPPCT 1152 Query: 2042 QEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVP--- 2098 +L ++ ALEK+ E+++K L E R+ Q++ + L ++LK Sbjct: 1153 GSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDY 1212 Query: 2099 -RFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLE---FRVR 2154 R Q + Q++E E + + L++ + E + K D QE LE F+ Sbjct: 1213 NRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLP-STDQQESCSSTPGLEEPLFKAT 1271 Query: 2155 E-------LEQALLVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQF 2207 E LE L + H A + Q++A+ I+ ++ E LE ++ Sbjct: 1272 EQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVE---LELKVSST 1328 Query: 2208 REELENKNEEVQQLHMQ-----LEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDA 2262 EL K+EEV QL Q LEI+ ++ + E+ E+ K + +L +A E Sbjct: 1329 TSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGLEH-- 1386 Query: 2263 MSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQL-KITTDNKVIEEKNELIRDLET 2321 ++ + ++I +KE ++ L+ Q+++ + L KI T+ I E+ +LI+ L T Sbjct: 1387 --LRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTE---IIEQEDLIKALHT 1441 Query: 2322 QIECLMSDQE----------CVKRNREEEIEQLNEVIEKLQQEL--ANIGQKTSMNAH-S 2368 Q+E + + C + + EEI + + +++Q++L A I +K ++ + S Sbjct: 1442 QLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKENKS 1501 Query: 2369 LSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRE 2428 L EE + ++ + +E QV N+E + L + ++L E+ E Sbjct: 1502 LQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLE 1561 Query: 2429 RESVEKIQSIPENSVNVAIDHLSKDKP----ELEVVLTEDALKSLENQTYFKSFEENGK- 2483 +S+ S S+ +A++ L++DK E+E + + +S E Q K ++ + Sbjct: 1562 NQSL----SSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEI 1617 Query: 2484 --GSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEE 2541 S N+ +++ V A E + Y +++ + + + LQ+ ++++ E+ Sbjct: 1618 LLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEK 1677 Query: 2542 KVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRIS 2601 A Q ++ ++E +N + +E + E L S+ S Sbjct: 1678 MRKFAKSKQQKILELEE------ENDRLRAEVHPAG-DTAKECMETLLSSNASMK----E 1726 Query: 2602 ELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEK-KRSPQD 2660 ELE V+M + +K Q ++EK+ L +E + +L+ +EGN KQ E ++ Sbjct: 1727 ELER--VKMEYETLSKKFQSLMSEKDSLSEEVQ--DLKHQIEGNVSKQANLEATEKHDNQ 1782 Query: 2661 VEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTS 2720 V + T+ E E ++L + T +E + A + + + Sbjct: 1783 TNVTEEGTQSIPGETE-----EQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINN 1837 Query: 2721 LQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLKI 2780 + + Q+++ +A +E+ + ++ ++ E++K + + K DG LK+ Sbjct: 1838 YLQQIDQLKERIAGLEEEKQ--KNKEFSQTLENEKNTLLSQISTK---------DGELKM 1886 Query: 2781 SSSNQTPQILVKNAGIQINLQSECSSEEVTEIISQFTEKIEKMQELHAAEILDMESRHIS 2840 T ++NL ++ EE++ ++ K++E E D+E R ++ Sbjct: 1887 LQEEVT----------KMNLLNQQIQEELS--------RVTKLKETAEEEKDDLEERLMN 1928 Query: 2841 ETETLK----------REHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTR 2890 + L + + +LL+ E LK + L ++ + E ++ + Sbjct: 1929 QLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRK 1988 Query: 2891 EICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESESATDS--FPKKIKGLLRAV------ 2942 E G+ G + ++ E + E + D + +KI L R V Sbjct: 1989 EYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFV 2048 Query: 2943 HNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINTISSLKDLITKMQLQREAEVY 3002 E + L +T+ + +H + +E L K ++ S + L+ + E+ Sbjct: 2049 QTESQKDLEITKENLAQAVEHRKKAQAE--LASFKVLLDDTQSEAARVLADNLKLKKELQ 2106 Query: 3003 DSSQSHESFSDWRGE----LLLALQQVFLEERSVL---LAAFRTELTALGTT--DAVGLL 3053 + +S +S + E L ++ L+E+ + L A R E L T + L Sbjct: 2107 SNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTL 2166 Query: 3054 NCLEQRIQE----------QGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKRE 3103 N ++ +Q+ Q + +M LQ DR ++ E + + + + + E Sbjct: 2167 NKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQD-DRDRVIDEAKKWERKFSDAIQSKEEE 2225 Query: 3104 QESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRA----TELQEQLSSEKMVVAELKSE 3159 ++ + +L+ ++Q M E+++ +S ++ ++ Q ++ ++ V L+ E Sbjct: 2226 IRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGE 2285 Query: 3160 LAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKE 3219 + +LE T H EL E+K D++ L+++L +++ L+ + ++ Sbjct: 2286 NKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQ 2345 Query: 3220 KAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIE----SQRML 3275 +A + S+ ++ DL+ S E + + ++N+ ++ LL+ ++ I+ R Sbjct: 2346 EADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQ 2405 Query: 3276 YDAQ-------LSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSS-DGTGQS 3327 +D + LS+E+ N+ L+ + + ++ TL ++ + Q ++ D +S Sbjct: 2406 HDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKS 2465 Query: 3328 RPPLPSE-DLLKELQKQLEEKHSRIV--------ELLNETEKYKLDSLQTRQQME----K 3374 L ++ D + +QLEE+H I+ E E K K + R M+ + Sbjct: 2466 MSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSE 2525 Query: 3375 DRQVHRKTLQTEQEAN------TEGQKKMHELQ----SKVEDLQRQLEEKRQQVYKLDLE 3424 + ++ + +Q ++ N QK++ E+Q ++E+ +LEEK ++ + + + Sbjct: 2526 NAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANED 2585 Query: 3425 GQRLQGIMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKE 3484 +R +QE +KQ+L +E ES ++ L T +L + T Q + KE Sbjct: 2586 LRRSFNALQE-EKQDLSKE--IESLKVSISQLTRQVT-ALQEEGTLGLYHAQL---KVKE 2638 Query: 3485 SNYAKLIEMNGGGTGCNHELEMIRQKLQCV----ASKLQVLPQKASERL----------- 3529 +L + ELE ++L CV A K+ + K + L Sbjct: 2639 EEVHRLSALFSSSQKRIAELE---EELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMR 2695 Query: 3530 -QFETADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQNAELT 3588 + ETA++ V E +++ QKL E L + S G L Sbjct: 2696 NETETAEER----VAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHAN 2751 Query: 3589 GHISQLTEEKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWN 3648 + +L + + + +L+EQ R+ A ++ FS+N + E S E N Sbjct: 2752 EELDELKRKYDASLKELAQLKEQGLLNRERDALLSETA-FSMN---STEENSLSHLEKLN 2807 Query: 3649 REKLTLQKSLKRAEAEVYKLKAELRNDS-LLQTLSPDSEHVTLKRIYGKYLRAESFRKA 3706 ++ L+ + L +++ ++++ S + +L + +H+ + E FRK+ Sbjct: 2808 QQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHL--------WNELEKFRKS 2858 Score = 121 bits (304), Expect = 1e-26 Identities = 230/1172 (19%), Positives = 497/1172 (42%), Gaps = 183/1172 (15%) Query: 2 EDEERQKKLEAGKAKLAQFRQRKAQSDGQSPSKKQKKKRKTSSSKHDVSAHH-DLNIDQS 60 +DE+ +++LE + K +++K + +++K + + + V+ + D + Q Sbjct: 2119 KDEDLERRLEQAEEK--HLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQL 2176 Query: 61 QCNEMYINSSQRVESTVIPESTIMRTLHS---------GEITSHEQGFSVELES---EIS 108 Q N ++STV + +++ S E E+ FS ++S EI Sbjct: 2177 QEN---------LDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIR 2227 Query: 109 TTADDCSSEVNGCSFVMRTGKPTNLLREEEFGVDDSYSEQGAQ----DSPTHLEMMESEL 164 D+CS V++ + EE ++ S E Q + T +++ + Sbjct: 2228 LKEDNCS--------VLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVC 2279 Query: 165 AGKQHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDET 224 Q E +EL +LEE R Y + +L + E+ +K +T L+ +L++ + +K Sbjct: 2280 DTLQGENKELLSQLEETRHLYHSSQ-NELAKLESELKSLKDQLTDLSNSLEKCKEQKGNL 2338 Query: 225 MREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILT--HQQQLEEQDH 282 + Q + ++QL+ LQA +++ + H++ ++ Sbjct: 2339 EGIIRQQEADIQNSKFSYEQLETD---------------LQASRELTSRLHEEINMKEQK 2383 Query: 283 LLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEE 342 ++ K+E + I+ L+++ ++ K++EN +E +E+ ++EE N K ++ Sbjct: 2384 IISLLSGKEEAIQVAIAELRQQ----HDKEIKELENLLSQE-EEENIVLEEENKKAVD-- 2436 Query: 343 KKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVE 402 KT +L + L T K E +Q Q + +K+M +S Q +R +++G + Sbjct: 2437 -KTNQLMETLKTIKK---ENIQQKAQLDSFVKSM-----SSLQNDRD------RIVGDYQ 2481 Query: 403 ELQKRNHKDSQFETDIVQRMEQETQRKLEQ---LRAELDEMYGQ------QIVQMKQELI 453 +L++R+ + ++Q E + E+ LR+ +D++ + +++Q +++L Sbjct: 2482 QLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLN 2541 Query: 454 R------QHMAQMEEMKTRHKGEMENA-LRSYSNITVNEDQIKLMNVAINELNIKLQDTN 506 + Q+ E++ + E+EN + + +E+ + + + N L + QD + Sbjct: 2542 QVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLS 2601 Query: 507 SQKEKLKEELGLILEEKCALQRQ--LEDLVEELSFSREQIQRARQTIAEQESKLNEAHKS 564 + E LK + + + ALQ + L +L E++ R + + ++ E + Sbjct: 2602 KEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEE 2661 Query: 565 LSTVEDLKAEIVSASESRKELELKH----------EAEVTNYKI------------KLEM 602 L V+ A+ V E + + ELKH E E ++ KL M Sbjct: 2662 LVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLM 2721 Query: 603 LEKEKNAVLDRMAESQEAELERLRTQLLFSHEE--ELSK-----LKEDLEIEHRINIEKL 655 + KE N L +S + L+ ++EE EL + LKE +++ + + + Sbjct: 2722 VTKE-NKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLKEQGLLNRE 2780 Query: 656 KDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSE 715 +D L ++ + +E + L++K QL+ S+L+D + V S S+ Sbjct: 2781 RDALLSETAFSMNSTEENSLSHLEKL---NQQLLSKDEQLLHLSSQLED-SYNQVQSFSK 2836 Query: 716 EMTLQINE---LQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQ 772 M NE L E+E R+ E+ K + + + L+K M +ND Sbjct: 2837 AMASLQNERDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQND------- 2889 Query: 773 LEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDL 832 + +LK+ K + L+I+ +++ L +K++ ++ ++ + + E+L Sbjct: 2890 ---RDRLLKELKNLQQQYLQINQEITE------LHPLKAQLQE--YQDKTKAFQIMQEEL 2938 Query: 833 KQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKD-DLEDSKNK-QELEYK 890 +Q+ + E+ + R + ++E++ + ++E+Y + KD L +N +EL Sbjct: 2939 RQENLSWQHELHQLR----MEKSSWEIHERRMKEQYLMAISDKDQQLSHLQNLIRELRSS 2994 Query: 891 SKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKR 950 S + + ++ +P T S+ D + V ET E T+L + L+ + Sbjct: 2995 SSQTQPLKVQYQRQASPET----SASPDGSQNLVYET-------ELLRTQLNDSLKEIHQ 3043 Query: 951 EKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQ 1010 ++L + Q S+ S+ L++K+ L + +SL++ ++ ++NH Q Sbjct: 3044 KELRIQQLNSNFSQLLEEKNTLSIQLCDTSQSLRENQQHYG-------DLLNHCAVLEKQ 3096 Query: 1011 SCDTQVSSLLDGVVTMTSRGAEG--------SVSKVNKSFGEESKIMVEDKVSFENM-TV 1061 + Q L V + G + + +SF E + + + + + Sbjct: 3097 VQELQAGPLNIDVAPGAPQEKNGVHRKSDPEELREPQQSFSEAQQQLCNTRQEVNELRKL 3156 Query: 1062 GEESKQEQLILDHLPSVTKESSLRATQPSEND 1093 EE + +++ ++ SV +E +R + SE D Sbjct: 3157 LEEERDQRVAAENALSVAEE-QIRRLEHSEWD 3187 Score = 75.1 bits (183), Expect = 1e-12 Identities = 119/591 (20%), Positives = 239/591 (40%), Gaps = 64/591 (10%) Query: 3115 EYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQ 3174 + N++ L + ++ ++QE+L+ + +V ELK + Q ++L+ +A Sbjct: 23 DQNMRAPLDPELHQESDMEFNNTTQEDVQERLAYAEQLVVELKDIIRQKDVQLQQKDEAL 82 Query: 3175 HKHLK----ELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERD 3230 + K +++ +L K K ++ + + ++ + E++ +K +S + Sbjct: 83 QEERKAADNKIKKLKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEE 142 Query: 3231 KEELEDLKFSLESQKQ--RNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNL 3288 + E+E +K L+ +++ LQ L Q +Q S + E M Q EE L Sbjct: 143 EMEIEKIKHKLQEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTL 202 Query: 3289 ELQV----LLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQL 3344 + Q+ ++ + +RE + + + LH + Q+ + L+ LQ++L Sbjct: 203 QAQLSQTQAEQAAQQVVREKDARFETQVRLHED-ELLQLVTQADVETEMQQKLRVLQRKL 261 Query: 3345 EEK------HSRIVELLNE----TEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEAN---- 3390 EE +++V+LL + E+ Q QQME + R T++TE+E + Sbjct: 262 EEHEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKILL 321 Query: 3391 -------TEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELERE 3443 E + H LQ ++ L Q E+ Q +L+ L+ QK + E E Sbjct: 322 EKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALE------QKHKAEME 375 Query: 3444 EKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHE 3503 EK L + E + + +LQ K E + + + +E Sbjct: 376 EKTSHILSLQKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLE----------- 424 Query: 3504 LEMIRQKLQCVASKLQVLPQKASERLQFETADDEDFIWVQENIDEIILQLQK-LTGQQGE 3562 + ++QK + ++ L LP + E + D Q +E I LQK + + E Sbjct: 425 -DQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTEENIASLQKRVVELENE 483 Query: 3563 EPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKLEEQIRWYRQTGAGR 3622 + +L+ S E L +N +L+ I+ L + +N + + ++ Sbjct: 484 KGALLLSSIE----LEELKAENEKLSSQITLL-----EAQNRTGEADREVSEISIVDIAN 534 Query: 3623 DNSSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRAEAEVYKLKAELR 3673 SS +G +E + + ++E L +K A+ E+ LK +L+ Sbjct: 535 KRSSSAEESGQDVLENTFSQK----HKELSVLLLEMKEAQEEIAFLKLQLQ 581 Score = 33.9 bits (76), Expect = 3.2 Identities = 64/324 (19%), Positives = 124/324 (38%), Gaps = 56/324 (17%) Query: 3356 NETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKR 3415 ++T++ L E D + + T + QE ++ + EL+ + QL++K Sbjct: 20 DDTDQNMRAPLDPELHQESDMEFNNTTQEDVQERLAYAEQLVVELKDIIRQKDVQLQQK- 78 Query: 3416 QQVYKLDLEGQRLQGIMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQ 3475 + L+ E K +I L+ LTS ++ + Sbjct: 79 ---------------------DEALQEERKAADNKIKKLKLHAKA--KLTS--LNKYIEE 113 Query: 3476 QKIEG----ETKESNYAKLIEMNGGGTGCNHELEMIRQKLQ----CVASKLQVLPQKASE 3527 K +G T+ + +L + + T E+E I+ KLQ +++ L Q +E Sbjct: 114 MKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQAQLTQAQAE 173 Query: 3528 RLQFETADDEDFIWVQENI---DEIILQLQ-KLTGQQGEEPSLVSPSTSCGSLTERLLRQ 3583 + + + E+F+ +++ + +E I LQ +L+ Q E+ + ++ Sbjct: 174 QPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAAQQVVREKDARFETQVRLH 233 Query: 3584 NAELTGHISQL---TEEKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRFSLNGGANIEAII 3640 EL ++Q TE + LR + KLEE SL G A + ++ Sbjct: 234 EDELLQLVTQADVETEMQQKLRVLQRKLEEH---------------EESLVGRAQVVDLL 278 Query: 3641 ASEKEVWNREKLTLQKSLKRAEAE 3664 E + L + L++ EAE Sbjct: 279 QQELTAAEQRNQILSQQLQQMEAE 302 >gi|55770834 centromere protein F [Homo sapiens] Length = 3114 Score = 285 bits (730), Expect = 5e-76 Identities = 612/2997 (20%), Positives = 1249/2997 (41%), Gaps = 413/2997 (13%) Query: 170 EIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFL 229 E+EE R E++ + Q L + A + RD Q ++++ ++EK + Sbjct: 174 EVEERKRLEAEVKALQAKKASQTLPQ--ATMNHRDIARHQASSSVFSWQQEKTPS----- 226 Query: 230 ELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQK 289 L+ SQ+ I+ + AS + + + L K+ + HLL+ + Sbjct: 227 HLSSNSQRTPIR-RDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKA 285 Query: 290 KKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELK 349 + ++ +I+ L+ +++ +E E +V + QE + +E+ ++IE+EK + + Sbjct: 286 QNQELRNKINELELRLQGHEKEMKGQVN-----KFQELQLQLEKAKVELIEKEKVLNKCR 340 Query: 350 DKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNH 409 D+L + + Q++K +LT +RQ++E + ++E+ K Sbjct: 341 DELVRTTAQYDQASTKYTALEQKLK----KLTEDLSCQRQNAESARC---SLEQKIKEKE 393 Query: 410 KDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKG 469 K+ Q E QR Q ++ Q++A L Q +Q + + A+++++ T K Sbjct: 394 KEFQEELSRQQRSFQTLDQECIQMKARLT-----QELQQAKNMHNVLQAELDKL-TSVKQ 447 Query: 470 EMENALRSYSNITVNEDQ-IKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQR 528 ++EN L + +Q + + NEL +++ + LK E C L+ Sbjct: 448 QLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEA 507 Query: 529 QLEDLVEELSFSREQIQRARQTIAEQES-------KLNEAHKSLSTVEDLKAEIVSASES 581 +L+++ + L+ S+ + + QE+ K+N+ SL T+E LK + + Sbjct: 508 ELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSL-TLEKLKLAVADLEKQ 566 Query: 582 R---KELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQ-LLFS-HEEE 636 R ++L K E + KL EKE A+L + E ++ E E L+ + LFS + E Sbjct: 567 RDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSAL-ELKKKEYEELKEEKTLFSCWKSE 625 Query: 637 LSKLKEDLEIEHRINIEKLKDNLGIHYK-QQIDGLQNEMSQKIETMQFEKDNLITKQNQL 695 KL +E E + N++ ++L K QQI +E ++++ T++ +++NL + L Sbjct: 626 NEKLLTQMESE-KENLQSKINHLETCLKTQQIK--SHEYNERVRTLEMDRENLSVEIRNL 682 Query: 696 ILEISKLKDLQQSLVNSKSEEMTLQ---INELQKEIEILRQEEKEK--------GTLEQE 744 ++++SKS E+ Q ELQ++ E Q+ +++ L + Sbjct: 683 -----------HNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQ 731 Query: 745 VQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTL---EDMLKIHTPVSQEE 801 V++L+ K +LL ++ +K+ Q+ A+ E+ +LK + +L ED + Q+ Sbjct: 732 VEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQP 791 Query: 802 RLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNY 861 + + + S+ + E +E ++ K I ++ + ++ F+ ++ + Sbjct: 792 AMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAI-----LQNRVDSLEFSLESQKQMN 846 Query: 862 QELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDK 921 +LQ++ L+++K ++E++ K E ++S + + QRI+ K++ + Sbjct: 847 SDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETS-----QRIS----KLQEDT-SAHQ 896 Query: 922 TFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVK 981 VAETL E EK+ L +K+E + E EL + L + LK E+ L+E + Sbjct: 897 NVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLK----ELQLLSETLS 952 Query: 982 SLKQEKEQ-VSLRCRELEIIINHNRA--ENVQSCDTQVSSLLDGVVTMTS--RGAEGSVS 1036 K+E +SL RE+E + N E S + + +L+ + + E S+S Sbjct: 953 LEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSIS 1012 Query: 1037 KVNKSFGEESKIMVE---------DKVSFENMTVGEESKQEQLILDHLPSVTKE-----S 1082 +++ + +E I+++ + +S + E++ + + +L+ S+ + Sbjct: 1013 ELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELE 1072 Query: 1083 SLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKA 1142 L+ E+ + +L + +L L++E + L ++ + N K +A Sbjct: 1073 QLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALR-------SEMTDNQNNSKSEA 1125 Query: 1143 LCSLKEELIFAQEEK---IKELQKIHQLELQTMKTQETGD-----EGKPLHLLIGKLQKA 1194 LK+E++ +EE+ KE+ + Q Q MK +T E +P+ + K +++ Sbjct: 1126 -GGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSV-KERES 1183 Query: 1195 VSEECSYFLQTLCSV----LGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYEVQ 1250 +C++ Q V L Y ++ E +KE + + E + ++E+Q Sbjct: 1184 ERNQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLRNKELK----LQESEKEKECLQHELQ 1239 Query: 1251 DFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQ 1310 + ++ T + L + Q+ G+K + + EE H Sbjct: 1240 TIRGDLET----------------SNLQDMQSQEISGLK----DCEIDAEEKYISGPHEL 1279 Query: 1311 MTNLED---IDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIHC 1367 T+ D + + ++ ++ L +LEK Q ++ E L++ L E I Sbjct: 1280 STSQNDNAHLQCSLQTTMNKLNELEKICEILQAEKYE-LVTELNDSRSEC-------ITA 1331 Query: 1368 LQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEETN 1427 +K + V + ++ V I D+ + G V+ G EF + + + Sbjct: 1332 TRKMAEEVGKL-------LNEVKILNDDS--GLLHGELVEDIPGG--EFGEQPNEQHPVS 1380 Query: 1428 IVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHY 1487 + L E E L ++ V M A Q+ L S Q+ +QH Sbjct: 1381 LAPLDESNSYEHL--TLSDKEVQMHFAELQEKFL------------SLQSEHKILHDQHC 1426 Query: 1488 FNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLT 1547 K+S+ Q + + ++ + G+ KE+ L + S CV Sbjct: 1427 QMSSKMSELQTYVDSLKAENLVLSTNLRNFQ---GDLVKEMQLGLEEGLVPSLSSSCVPD 1483 Query: 1548 ISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATEL 1607 S D +F +++ ++ S+ ++ + ++ Q + + QE + Sbjct: 1484 SSSLSSLGDSSFY--RALLEQTGDMSLLSNLEGAVSANQC-SVDEVFCSSLQEENLTRKE 1540 Query: 1608 LRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLS 1667 A + +E E ++ +++L ++ + + N +E++ L+QL Sbjct: 1541 TPSAPAKGVEELESLCEVYRQSLEKLEEKMESQGIMKN------------KEIQELEQLL 1588 Query: 1668 LAGREKLCCELRNSSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKA 1727 + R++L C + Q +EN+ ++ T E++ K A +K Sbjct: 1589 SSERQELDC------LRKQYLSENEQWQQKLTSVTLEMESK-------------LAAEKK 1629 Query: 1728 NNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSC-VHEE 1786 L + LEV + + R +LGI + ++ R+E SC + +E Sbjct: 1630 QTEQLSLELEVARLQLQGLDLSSRSLLGI-------DTEDAIQGRNE------SCDISKE 1676 Query: 1787 HTRVTDESIPSYSGSDM----PRNDINM-WSKVTEEGTELSQRLVRSGFAGTEIDPENEE 1841 HT T E P + + + D+N+ K+TE G + +G E P+ Sbjct: 1677 HTSETTERTPKHDVHQICDKDAQQDLNLDIEKITETGA-----VKPTGECSGEQSPDT-- 1729 Query: 1842 LMLNISSRLQAAVEKLLEAISETSSQLEHAKV------TQTELMRESFRQKQEATESLKC 1895 N + + E ISE S +A V Q ++ R K+ + E+L+ Sbjct: 1730 ---NYEPPGEDKTQGSSECISELSFSGPNALVPMDFLGNQEDIHNLQLRVKETSNENLRL 1786 Query: 1896 QEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCA 1955 + +R R E L E+ + + + L E Q+ K + LE+ Sbjct: 1787 LHVIEDR----DRKVESLLNEMKELDSKLH-------LQEVQLMTKIEACIELEK----- 1830 Query: 1956 SNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEK- 2014 + EL+ E + E+ E S Q+LLQ E +++ A+K Sbjct: 1831 --IVGELKKENSDLSEKLEYFSCD-----------HQELLQRVETSEGLNSDLEMHADKS 1877 Query: 2015 VRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQ---LEKMRKFLDE 2071 R+D+ V + +E RF+++E EL +R + ++E + LE + + Sbjct: 1878 SREDIGDNVAKVNDSWKE---RFLDVE----NELSRIRSEKASIEHEALYLEADLEVVQT 1930 Query: 2072 QAIDREHERDVFQQEIQKLEQQLKVV--PRFQPISE-----HQTREVEQLANHLKEKTDK 2124 + + E + + Q+ I LE++L VV R Q E +T ++QL+ +KEKT + Sbjct: 1931 EKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQE 1990 Query: 2125 C----SELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVEDRKHFGAVEAKPELSLE 2180 SE L + + +++E+ E ++ L V EL + K + LSL Sbjct: 1991 LESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLT 2050 Query: 2181 VQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLE---IQKKESTTRLQ 2237 + A KEKE+ L ++ E + L + E + LE ++K E RL Sbjct: 2051 KCELENQIAQLNKEKEL--LVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLS 2108 Query: 2238 ELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQ 2297 ++E + +EKL + I +A + H+ A+ ++E+E E D L ++V L+ Sbjct: 2109 STQEEVHQLRRGIEKLRVRI---EADEKKQLHI-----AEKLKERERENDSLKDKVENLE 2160 Query: 2298 QQLKITTDNKVI-----EEKNELIRDLETQIECLMSDQECVKRN---REEEIEQLNEVIE 2349 ++L+++ +N+ + E + L+TQIE + + + + E E L + I+ Sbjct: 2161 RELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQ 2220 Query: 2350 KLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKL-----ALEQQVETANEEMTFM 2404 + Q +L+ + K + SL EE K Q ++ I E+ L+ Q++ NE + + Sbjct: 2221 EKQGQLSEL-DKLLSSFKSLLEE----KEQAEIQIKEESKTAVEMLQNQLKELNEAVAAL 2275 Query: 2405 ---KNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVV- 2460 + ++K T ++ +E L+ E + E + L + + +++ Sbjct: 2276 CGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLK 2335 Query: 2461 -LTEDALKSLE----NQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIK 2515 E+ + LE NQ + EN KG + L+ ++ + ++ +L++ + + Sbjct: 2336 GRVENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKE 2395 Query: 2516 DMQEQGQFETEMLQK-KIVN------LQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQT 2568 ++ + Q E E + + +I+N LQ+ +EKV S +E +Q K + N+ Sbjct: 2396 NLTNELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLK--ELNER 2453 Query: 2569 ISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNV 2628 +++ N Q + +E L S + L L ++L + E + I+ + V + V Sbjct: 2454 VAA---LHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEV 2510 Query: 2629 LEKEKKLLELQKLLEGNEKKQREKEK-KRSPQDVEVLKTTTELFHSNEESGFFNELEALR 2687 + ++KL EKK E + K QD E L + + LE LR Sbjct: 2511 EDGKQKL----------EKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLE-LR 2559 Query: 2688 AESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVR-DHLAEAKEKLSILEKED 2746 +V + ++ + K LQ+ L V +++ +L+ +L + D ++ ++ + KE Sbjct: 2560 NLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKET 2619 Query: 2747 ETEVQESKKACMFEPLPIKLSKSIASQTDGTLKI------SSSNQTPQILVKNAGIQINL 2800 E + + + A L +LS ++ G L++ SS +Q ++ ++N+ ++ +L Sbjct: 2620 ELQREMHEMAQKTAELQEELSGE-KNRLAGELQLLLEEIKSSKDQLKELTLENSELKKSL 2678 Query: 2801 QSECSSE-----EVTEIISQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQL 2855 + +V E I+++ ++ + ++ H A +LD ++ E +T + + Sbjct: 2679 DCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREK-----LT 2733 Query: 2856 LKEEC-GTLKAVIQCLRSKEGSSIPELAHSDAYQTREICSSDSGSDWGQGIYLTHSQGFD 2914 KEEC + K I L+S + E ++ T +I + Y+ + + Sbjct: 2734 SKEECLSSQKLEIDLLKSSK-----EELNNSLKATTQILEELKKTKMDNLKYVNQLKKEN 2788 Query: 2915 IASEGR-------GEESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQ 2967 ++G+ ++ E + K++ L A + + T+ E +++ Sbjct: 2789 ERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQEKQKTGTVMDTKVDELTTEIKELKE 2848 Query: 2968 VSEPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSH----ESFSDWRGELLL 3020 E +E Y++ SL LI+ +L++ E+ ++ +H +S D RG LL Sbjct: 2849 TLEEKTKEADEYLDKYCSL--LISHEKLEKAKEMLETQVAHLCSQQSKQDSRGSPLL 2903 Score = 215 bits (548), Expect = 6e-55 Identities = 637/3141 (20%), Positives = 1237/3141 (39%), Gaps = 514/3141 (16%) Query: 501 KLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQ---TIAEQESK 557 K+Q+ Q +KLK+E K Q QL+ L L +++++ + + + + Sbjct: 19 KIQELEGQLDKLKKE-------KQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQR 71 Query: 558 LNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAES 617 L E +SL + + + ES+ + E ++ + K ++E LE+E + S Sbjct: 72 LMEICESLEKTKQKISHELQVKESQVNFQ---EGQLNSGKKQIEKLEQELKRCKSELERS 128 Query: 618 QEA------ELERLRT-QLLFS-------------HEEELSKLKEDLEIEHRINIE---- 653 Q+A L T Q +F+ +E+ K +++E R+ E Sbjct: 129 QQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVKAL 188 Query: 654 ---KLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLV 710 K L D +++ S + + Q EK N I + D S Sbjct: 189 QAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRR--DFSASYF 246 Query: 711 NSKSE----EMTLQINELQKEIE---------ILRQEEKEKGTLEQEVQELQLKTELLEK 757 + + E TLQI + +L Q + + L ++ EL+L+ + EK Sbjct: 247 SGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELRLQGHEK 306 Query: 758 QMKEKENDLQEKFAQLEAENSILKDEKKTL---EDMLKIHTPVSQEERLIFLDSIKSKSK 814 +MK + N QE QLE L +++K L D L + T ++ +++ K K Sbjct: 307 EMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDEL-VRTTAQYDQASTKYTALEQKLK 365 Query: 815 DSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACL--- 871 K E L + ++ + L ++I+++ F + ++Q L +E C+ Sbjct: 366 -----KLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQE--CIQMK 418 Query: 872 LKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMG 931 ++ +L+ +KN + +++L L Q++ + K + ++ F A ++ Sbjct: 419 ARLTQELQQAKNMHNV-LQAELDKLTSV--KQQLENNLEEFKQKLCRAEQAFQASQIKEN 475 Query: 932 EV------VEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQ 985 E+ ++K+ L E RE L L ++ + L Q EE+K+ K Sbjct: 476 ELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQN----FAEEMKA-KN 530 Query: 986 EKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEE 1045 ++ LR + +I N+ EN + + ++ D R + K + E+ Sbjct: 531 TSQETMLRDLQEKI----NQQENSLTLEKLKLAVAD---LEKQRDCSQDLLKKREHHIEQ 583 Query: 1046 --SKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLK 1103 K+ +K S ++ E K+E + +E +L + SEN+KL L ++ Sbjct: 584 LNDKLSKTEKESKALLSALELKKKE------YEELKEEKTLFSCWKSENEKL---LTQME 634 Query: 1104 SEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEEL---------IFAQ 1154 SE+ +L+ ++ CL Q++ + NE+ + L +E L + Sbjct: 635 SEKENLQSKINHLETCLK------TQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDS 688 Query: 1155 EEKIKELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYY 1214 + E QK+ +ELQ + E D+ K QK + C Q V Sbjct: 689 KSVEVETQKLAYMELQ--QKAEFSDQ---------KHQKEIENMCLKTSQLTGQV----- 732 Query: 1215 TPALKCEVNAEDKENSGDYISE---NEDPELQDYRYEVQDFQENMHTL-LNKVTEE---- 1266 ED E+ +S ++D QD E + ++ + + + VT E Sbjct: 733 ----------EDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQR 782 Query: 1267 ----YNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHK 1322 +++ + + I G+Q M E E L +++ S Q ++ ++ + + Sbjct: 783 SLLAFDQQPAMHHSFANIIGEQ-GSMPSERSECRLEADQSPKNSAILQ-NRVDSLEFSLE 840 Query: 1323 SKLSSLQDLEKT---------KLEEQVQELE----SLISSLQQQLKETEQNYEAEIHCLQ 1369 S+ DL+K ++EE + + E S ++ Q++ + +++ A + + Sbjct: 841 SQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVA 900 Query: 1370 KRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGV--KEETN 1427 + L A+ L D V +++ Q ++ ++ S + KE ++ Sbjct: 901 ETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSS 960 Query: 1428 IVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHY 1487 I+ L +++ +E +E ++ S+ ++ L + S N ++ +Q+ Sbjct: 961 IISLNKREIEELTQENGTLKEINASLN-QEKMNLIQKSESFANYIDEREKSISELSDQYK 1019 Query: 1488 FNEMKLSQ--DQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCV 1545 ++ L Q ++ G +E + K+K + SK E LL+ + E++ Sbjct: 1020 QEKLILLQRCEETG-NAYEDLSQKYKAAQEKNSK------LECLLNECT--SLCENRKNE 1070 Query: 1546 LTISEEMFSKD-KTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQA 1604 L +E F+K+ + F+ + + +E ++ LML +LE ++Q L + ++Q Sbjct: 1071 LEQLKEAFAKEHQEFLTKLAFAEE-------RNQNLML---ELETVQQALRSEMTDNQNN 1120 Query: 1605 TELLRQAHMRQMERQREDQEQLQEEIKRL---NRQL--AQRSSIDNENLVSERERVLLEE 1659 ++ +++ +E+Q ++Q+E+ L N QL ++ + +NL SE R ++E Sbjct: 1121 SKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKE 1180 Query: 1660 LEALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSN 1719 E+ ++ + ++ E++ S + N Q E + KEL + + E L + Sbjct: 1181 RES-ERNQCNFKPQMDLEVKEISLDSYNAQLVQ---LEAMLRNKELKLQESEKEKECLQH 1236 Query: 1720 ERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASV 1779 E LQ L T+ +++ + + G+ D +AE Sbjct: 1237 E---LQTIRGDL---------ETSNLQDMQSQEISGLKD------------CEIDAEEKY 1272 Query: 1780 KSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPEN 1839 S HE T D + S N +N K+ E LV TE++ Sbjct: 1273 ISGPHELSTSQNDNAHLQCS-LQTTMNKLNELEKICEILQAEKYELV------TELNDSR 1325 Query: 1840 EELMLNISSRLQAAVEKLLEAIS--ETSSQLEHAKVTQTELMRESFRQKQEA-TESLKCQ 1896 E + + ++ V KLL + S L H ++ + E Q E SL Sbjct: 1326 SE-CITATRKMAEEVGKLLNEVKILNDDSGLLHGELVEDIPGGEFGEQPNEQHPVSLAPL 1384 Query: 1897 EELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQ------EKTDIIDRLEQ 1950 +E H +E E + ++ K L ++ Q E +D L+ Sbjct: 1385 DESNSYEHLTLSDKEVQMHFAELQEKFLSLQSEHKILHDQHCQMSSKMSELQTYVDSLKA 1444 Query: 1951 ELLCASNRLQELEAE---QQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLE 2007 E L S L+ + + + Q+ E L+ ++ + P L + L Sbjct: 1445 ENLVLSTNLRNFQGDLVKEMQLGLEEGLV----PSLSSSCVPDSSSLSSLGDSSFYRALL 1500 Query: 2008 VQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTE--------LMDLRQQNQALE 2059 Q + +L+ V A + V+E ++ E E + +L + Sbjct: 1501 EQTGDMSLLSNLEGAVSANQCSVDEVFCSSLQEENLTRKETPSAPAKGVEELESLCEVYR 1560 Query: 2060 KQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQ---------TRE 2110 + LEK+ + ++ Q I + E +Q + Q+L + R Q +SE++ T E Sbjct: 1561 QSLEKLEEKMESQGIMKNKEIQELEQLLSSERQELDCL-RKQYLSENEQWQQKLTSVTLE 1619 Query: 2111 VEQLANHLKEKTDKCS-ELLLSKEQLQ---------------RDIQERNEEIEKLEFRVR 2154 +E K++T++ S EL +++ QLQ IQ RNE + + Sbjct: 1620 MESKLAAEKKQTEQLSLELEVARLQLQGLDLSSRSLLGIDTEDAIQGRNESCDISKEHTS 1679 Query: 2155 ELEQALLVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENK 2214 E + D +A+ +L+L+++ E A+ + E + + + E+K Sbjct: 1680 ETTERTPKHDVHQICDKDAQQDLNLDIEKITETGAV-KPTGECSGEQSPDTNYEPPGEDK 1738 Query: 2215 NEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFG- 2273 + + +L + + L + +D+ L L +KE+ + + HV+ Sbjct: 1739 TQGSSECISELSFSGPNALVPMDFLGNQ-----EDIHNLQLRVKETSNENLRLLHVIEDR 1793 Query: 2274 --KFAQIIQEKEVEIDQLNEQVTKLQQQL-----------KITTDNKVIEEK-------- 2312 K ++ E + +L+ Q +L ++ ++ +N + EK Sbjct: 1794 DRKVESLLNEMKELDSKLHLQEVQLMTKIEACIELEKIVGELKKENSDLSEKLEYFSCDH 1853 Query: 2313 NELIRDLETQIECLMSDQE--CVKRNREEEIEQLNEVIEKLQQELANIGQKTS---MNAH 2367 EL++ +ET E L SD E K +RE+ + + +V + ++ ++ + S Sbjct: 1854 QELLQRVETS-EGLNSDLEMHADKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKA 1912 Query: 2368 SLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKR 2427 S+ EA L+ L+VV EKL LE+ E + + ++ L + NQL EL ++ + Sbjct: 1913 SIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSK 1972 Query: 2428 ERESVEKIQSIPENSVNVAIDHLS-------------KDKPELEVVLTEDALKSLENQTY 2474 + +++++ + H S K+K EL L+ D + L+++T+ Sbjct: 1973 KTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTH 2032 Query: 2475 FKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVN 2534 L+ +L LE A L LT+C ++++ Q E E+L K+ + Sbjct: 2033 --------------LQEKLQSLEKDSQA--LSLTKC--ELENQIAQLNKEKELLVKESES 2074 Query: 2535 LQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDIS 2594 LQ + E S+ E+ N+ + E G Sbjct: 2075 LQARLSE-----------------------------SDYEKLNVSKALEAALVEKGE--- 2102 Query: 2595 ALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEK 2654 LR+S + +V ++ + + ++E EK L +KL K+RE+E Sbjct: 2103 -FALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKL------------KEREREN 2149 Query: 2655 KRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLVK 2714 VE L+ ++ N+ EL L AE+ +KAE+ + K + E++ L V Sbjct: 2150 DSLKDKVENLERELQMSEENQ------ELVILDAEN--SKAEVETLKTQIEEMARSLKVF 2201 Query: 2715 ETNMTSLQKDLSQVRDHLAEAKEKL-----------SILEKEDETEVQ---ESKKAC-MF 2759 E ++ +L+ + + + E + +L S+LE++++ E+Q ESK A M Sbjct: 2202 ELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEML 2261 Query: 2760 EPLPIKLSKSIAS--QTDGTLKISSSNQTPQI----LVKNAGIQINLQSECSSEEVTEII 2813 + +L++++A+ +K + + P I ++N+ ++ + E ++ ++ Sbjct: 2262 QNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVL 2321 Query: 2814 SQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVI----QC 2869 Q E E +L + ++E R + T + + + K E TLKA I Q Sbjct: 2322 QQLKES-EHHADLLKGRVENLE-RELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQS 2379 Query: 2870 LRSKEGSSIPELAHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIASEGR------GEE 2923 LR E + + T E+ + + + +S +I E E+ Sbjct: 2380 LRGLE-LDVVTIRSEKENLTNEL---QKEQERISELEIINSSFENILQEKEQEKVQMKEK 2435 Query: 2924 SESATDSFPKKIKGL---LRAVHNEGMQVLSLTESPYSDGEDHSIQ--QVSEPWLEERKA 2978 S +A + ++K L + A+HN+ + ++ S E ++ Q+ + E + Sbjct: 2436 SSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNN 2495 Query: 2979 YINTISSLKDLIT-----KMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVL 3033 YI SS+ LI K +L+++ E + S+ D + +L+ L QV E L Sbjct: 2496 YIVLQSSVNGLIQEVEDGKQKLEKKDE--EISRLKNQIQD-QEQLVSKLSQV--EGEHQL 2550 Query: 3034 LAAFRTELTALGTTDAVGLLNCLEQRI---QEQGVEYQAAMECLQKADRRSLLSEIQALH 3090 EL L LEQ+I Q + Q +E LQ + + Sbjct: 2551 WKEQNLELRNLTVE--------LEQKIQVLQSKNASLQDTLEVLQSSYK----------- 2591 Query: 3091 AQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEK 3150 L+ E E K + + + ++ E+Q E+ M + ELQE+LS EK Sbjct: 2592 --------NLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEK 2643 Query: 3151 --------MVVAELKS------ELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVH 3196 +++ E+KS EL EL+ +L HK E E +V+++ E Sbjct: 2644 NRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEG---KVREEIAEYQ 2700 Query: 3197 LLNDTLASEQKKSRELQWALEKE---KAKLGRSEERDKEE-LEDLKFSLESQKQRNLQLN 3252 L L +KK + L K+ + + R + KEE L K ++ K +LN Sbjct: 2701 L---RLHEAEKKHQALLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSKEELN 2757 Query: 3253 LLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRER 3312 L+ Q+L E +K + + Y QL +E R LL ++ E L +E Sbjct: 2758 NSLKATTQIL-EELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKEL 2816 Query: 3313 ELHAQLQSSDGTGQSRPPLPSE--DLLKELQKQLEEKHSRIVELLNETEKYKL--DSLQT 3368 Q TG E +KEL++ LEEK E L++ + + L+ Sbjct: 2817 SQLQAAQEKQKTGTVMDTKVDELTTEIKELKETLEEKTKEADEYLDKYCSLLISHEKLEK 2876 Query: 3369 RQQMEKDRQVHRKTLQTEQEA 3389 ++M + + H + Q++Q++ Sbjct: 2877 AKEMLETQVAHLCSQQSKQDS 2897 Score = 212 bits (540), Expect = 5e-54 Identities = 459/2325 (19%), Positives = 961/2325 (41%), Gaps = 408/2325 (17%) Query: 145 YSEQGAQDSPTHLEMMESELAGKQHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRD 204 +S + + + L+ EL + EIEE + E+M ++ E Q++ + + Sbjct: 837 FSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQ 896 Query: 205 GIITQLTANLQQARREKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLL 264 ++ + + L+ +E + + + +E TEQ++ Sbjct: 897 NVVAETLSALENKEKEL-QLLNDKVE-TEQAE---------------------------- 926 Query: 265 QAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEI 324 Q+L++ +HLLED K ++ L E + + E ++ + + NK EI Sbjct: 927 ---------IQELKKSNHLLEDSLK-------ELQLLSETLSL-EKKEMSSIISLNKREI 969 Query: 325 QE---KETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELT 381 +E + ++E+N + +E+ + L K + + E ++ I + + + K KL L Sbjct: 970 EELTQENGTLKEINASLNQEK---MNLIQKSESFANYIDEREKSISELSDQYKQEKLILL 1026 Query: 382 NSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMY 441 ++ + E++ Q +K +Q + ++ + E E + EL+++ Sbjct: 1027 QRCEETGNAYEDLSQ-----------KYKAAQEKNSKLECLLNECTSLCENRKNELEQL- 1074 Query: 442 GQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSY-SNITVNEDQIKLMNVAINELNI 500 + + QE + + +A EE E+E ++ S +T N++ K L Sbjct: 1075 KEAFAKEHQEFLTK-LAFAEERNQNLMLELETVQQALRSEMTDNQNNSK---SEAGGLKQ 1130 Query: 501 KLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNE 560 ++ ++ K+++E+ +L+E L + ++ E + E I R ++ E+ES+ N+ Sbjct: 1131 EIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEPI---RNSVKERESERNQ 1187 Query: 561 AHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEA 620 + DL+ + +S +L ++ EA + N ++KL+ EKEK L ++ Sbjct: 1188 C--NFKPQMDLEVKEISLDSYNAQL-VQLEAMLRNKELKLQESEKEKEC-LQHELQTIRG 1243 Query: 621 ELERLRTQLLFSHEEELSKLKEDLEIE---------HRINIEKLKDNLGIHYKQQID-GL 670 +LE Q + S +E+S LK D EI+ H ++ + DN + Q Sbjct: 1244 DLETSNLQDMQS--QEISGLK-DCEIDAEEKYISGPHELSTSQ-NDNAHLQCSLQTTMNK 1299 Query: 671 QNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEI 730 NE+ + E +Q EK L+T+ N +S + + +M ++ +L E++I Sbjct: 1300 LNELEKICEILQAEKYELVTELND-----------SRSECITATRKMAEEVGKLLNEVKI 1348 Query: 731 LRQEE-------------KEKGTLEQEVQELQL----------KTELLEKQMKEKENDLQ 767 L + E G E + L L +K+++ +LQ Sbjct: 1349 LNDDSGLLHGELVEDIPGGEFGEQPNEQHPVSLAPLDESNSYEHLTLSDKEVQMHFAELQ 1408 Query: 768 EKFAQLEAENSILKDEKKTLED-MLKIHTPVS--QEERLIFLDSIKSKSKDSVWEKEIEI 824 EKF L++E+ IL D+ + M ++ T V + E L+ ++++ D V KE+++ Sbjct: 1409 EKFLSLQSEHKILHDQHCQMSSKMSELQTYVDSLKAENLVLSTNLRNFQGDLV--KEMQL 1466 Query: 825 LIEEN--EDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSK 882 +EE L C+ + + S + +F Y+ L E+ + + +LE + Sbjct: 1467 GLEEGLVPSLSSSCVPDSSSLS------SLGDSSF---YRALLEQTGD-MSLLSNLEGAV 1516 Query: 883 NKQELEYKSKLKALNEELHLQRINPTTVKMKS--------SVFDEDKTFVAETLEMGEVV 934 + + + +E +L R + K V+ + + E +E ++ Sbjct: 1517 SANQCSVDEVFCSSLQEENLTRKETPSAPAKGVEELESLCEVYRQSLEKLEEKMESQGIM 1576 Query: 935 EKDTTELMEKLEVTKREKLE-LSQRLSDLSEQLKQKHGEISF-LNEEVKSLKQEKEQVSL 992 + + +E+L ++R++L+ L ++ +EQ +QK ++ + ++ + K++ EQ+SL Sbjct: 1577 KNKEIQELEQLLSSERQELDCLRKQYLSENEQWQQKLTSVTLEMESKLAAEKKQTEQLSL 1636 Query: 993 RCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVED 1052 ELE+ +Q D SLL G+ T + ++K E+ E Sbjct: 1637 ---ELEV-----ARLQLQGLDLSSRSLL-GIDTEDAIQGRNESCDISKEHTSET---TER 1684 Query: 1053 KVSFENMTVGEESKQEQLILDHLPSVTKESSLRAT-------------QPSENDKLQKEL 1099 + + ++ Q+ L LD + +T+ +++ T +P DK Q Sbjct: 1685 TPKHDVHQICDKDAQQDLNLD-IEKITETGAVKPTGECSGEQSPDTNYEPPGEDKTQGSS 1743 Query: 1100 NVLKS----------EQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEE 1149 + + L Q + + L + +++ + ++ ++D+ + SL E Sbjct: 1744 ECISELSFSGPNALVPMDFLGNQEDIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLNE 1803 Query: 1150 LIFAQEEKIKEL-QKIHQLELQTMKTQETGDEGKPLHLLIGKLQKA---VSEECSYFLQT 1205 + KEL K+H E+Q M E E L ++G+L+K +SE+ YF Sbjct: 1804 M--------KELDSKLHLQEVQLMTKIEACIE---LEKIVGELKKENSDLSEKLEYFSCD 1852 Query: 1206 LCSVL-----GEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLL 1260 +L E L+ + +E+ GD +++ D ++ D + + + Sbjct: 1853 HQELLQRVETSEGLNSDLEMHADKSSREDIGDNVAKVND----SWKERFLDVENELSRIR 1908 Query: 1261 NKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKE----ETEFLSIHSQMTNLED 1316 ++ ++ L L+ L + QT+ + LE EN K E E + S+ L Sbjct: 1909 SEKASIEHEALYLEADLEVV---QTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRG 1965 Query: 1317 IDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVS 1376 +++ SK ++ D K++E+ QELES S ++ E + + LQ VS Sbjct: 1966 -ELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVS 2024 Query: 1377 ESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEETNI-VKLLEKQ 1435 E + + + E D+Q + C +N + E VKE ++ +L E Sbjct: 2025 ELLKDKTHLQEKLQSLEKDSQ-ALSLTKCELENQIAQLNKEKELLVKESESLQARLSESD 2083 Query: 1436 YQEQLEEEVAKVIVSMSIAFA-----QQTELSRISGGKENTASSKQAHAVCQQEQHYFNE 1490 Y++ + + + FA Q E+ ++ G E +A +++ H + Sbjct: 2084 YEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADE--KKQLHIAEK 2141 Query: 1491 MKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISE 1550 +K + E +K K E ++ E +E+++ D + + + T E Sbjct: 2142 LKERER-------ENDSLKDKVENLERELQMSEENQELVI--LDAENSKAEVETLKTQIE 2192 Query: 1551 EMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNE-EQLEDMRQELVRQYQEHQQATELLR 1609 EM K F E+ + ++ + ++ + + ++ + EL + + E Sbjct: 2193 EMARSLKVF--------ELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKE 2244 Query: 1610 QAHMRQMERQREDQEQLQEEIKRLNRQLA--------QRSSIDNENLVSERERVLLEELE 1661 QA ++ E + E LQ ++K LN +A +++ + + E E L +E Sbjct: 2245 QAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIE 2304 Query: 1662 ALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNER 1721 L+ A +K C L+ + + +G VE +E E+ R +N+ Sbjct: 2305 KLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLE-RELEIAR----------TNQE 2353 Query: 1722 YALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKS 1781 +A +A N ++ ET+ + G + +S + + RSE E Sbjct: 2354 HAALEAENSKGEV------------ETLKAKIEG-MTQSLRGLELDVVTIRSEKE----- 2395 Query: 1782 CVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQ-RLVRSGFAGTEIDPENE 1840 N+ +++ +E +S+ ++ S F + E E Sbjct: 2396 ---------------------------NLTNELQKEQERISELEIINSSFENILQEKEQE 2428 Query: 1841 ELMLNISS-----RLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKC 1895 ++ + S LQ +++L E ++ + E K ++Q + ++C Sbjct: 2429 KVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKA-----------KEQNLSSQVEC 2477 Query: 1896 QE-ELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLC 1954 E E + L A+ V S G+I D K +++++K + I RL+ ++ Sbjct: 2478 LELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGK----QKLEKKDEEISRLKNQI-- 2531 Query: 1955 ASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQ--QLLQETEKLMKEKLEVQCQA 2012 ++L ++ Q++ E +L Q ++ +EQ Q+LQ +++ LEV + Sbjct: 2532 --QDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSS 2589 Query: 2013 EKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQ 2072 K ++ + K ++ E+V++ E E E+ ++ Q+ L+++L Sbjct: 2590 YKNLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEEL---------- 2639 Query: 2073 AIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSK 2132 E++ E+Q L +++K S+ Q +E+ + LK+ D + K Sbjct: 2640 ----SGEKNRLAGELQLLLEEIK-------SSKDQLKELTLENSELKKSLD-----CMHK 2683 Query: 2133 EQLQRDIQERNEEIEKLEFRVRELE---QALLVEDRKHFGAVEAKPELSLEVQLQAERDA 2189 +Q++++ + R EEI + + R+ E E QALL++ K + EV++Q R+ Sbjct: 2684 DQVEKEGKVR-EEIAEYQLRLHEAEKKHQALLLDTNKQY-----------EVEIQTYREK 2731 Query: 2190 IDRKEKEITNLE---EQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLF 2246 + KE+ +++ + + L+ +EEL N + Q+ +L+ K ++ + +L++EN+ Sbjct: 2732 LTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKENERA 2791 Query: 2247 KDDMEKLGLAIKESDAMSTQDQHVLFGKFAQI--IQEK-------EVEIDQLNEQVTKLQ 2297 + M+ L + K+ + +++ +L + +Q+ QEK + ++D+L ++ +L+ Sbjct: 2792 QGKMKLLIKSCKQLE----EEKEILQKELSQLQAAQEKQKTGTVMDTKVDELTTEIKELK 2847 Query: 2298 QQLKITTDNK-----------VIEEKNELIRD-LETQIECLMSDQ 2330 + L+ T + EK E ++ LETQ+ L S Q Sbjct: 2848 ETLEEKTKEADEYLDKYCSLLISHEKLEKAKEMLETQVAHLCSQQ 2892 Score = 194 bits (494), Expect = 1e-48 Identities = 527/2879 (18%), Positives = 1158/2879 (40%), Gaps = 450/2879 (15%) Query: 972 EISFLNEEVKSLKQEKEQVSLRCRELEIIINHNR--AENVQSCDTQVSSLLDGVVTMTSR 1029 +I L ++ LK+EK+Q + LE + + EN ++ T + ++ + Sbjct: 19 KIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLMEICE- 77 Query: 1030 GAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQP 1089 S+ K + E ++ E +V+F+ + KQ + + L E R+ Q Sbjct: 78 ----SLEKTKQKISHELQVK-ESQVNFQEGQLNSGKKQIEKLEQELKRCKSELE-RSQQA 131 Query: 1090 SENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKD-----KALC 1144 +++ + LN + Q + + Y ++ + +E K KAL Sbjct: 132 AQSADVS--LNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVKALQ 189 Query: 1145 SLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEE--CSYF 1202 + K Q HQ Q+ E P HL + + + SYF Sbjct: 190 AKKASQTLPQATMNHRDIARHQASSSVFSWQQ---EKTPSHLSSNSQRTPIRRDFSASYF 246 Query: 1203 LQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPEL--------QDYRYEVQDFQE 1254 GE + + ++ + + + P L Q+ R ++ + + Sbjct: 247 S-------GEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELEL 299 Query: 1255 NMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMK-LEFGEENLPKEETEFLSIHSQMTN 1313 + ++ + NK LQ +L K + + K L + L + ++ ++ T Sbjct: 300 RLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTA 359 Query: 1314 LEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQ 1373 LE KL L + L Q Q ES SL+Q++KE E+ ++ E+ Q+ Q Sbjct: 360 LEQ-------KLKKLTE----DLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQ 408 Query: 1374 AVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLE 1433 + + + +T+ Q KN+ ++ + + T++ + LE Sbjct: 409 TLDQECIQMKAR-----LTQELQQA---------KNMHNVLQAE----LDKLTSVKQQLE 450 Query: 1434 KQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGG--KENTA----SSKQAHAVCQQEQHY 1487 +E ++++ + + + ++ EL R KEN S ++A VC E Sbjct: 451 NNLEE-FKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAEL 509 Query: 1488 FN-EMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSD--PHDIPESKDC 1544 N + L+Q Q + + + + + L +++ + + L D+ + +DC Sbjct: 510 KNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQRDC 569 Query: 1545 VLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQA 1604 S+++ K + I + ++D++S + ++ L E ++++ + +E + Sbjct: 570 ----SQDLLKKREHHI--EQLNDKLSKTEKESKALLSALE-----LKKKEYEELKEEKTL 618 Query: 1605 TELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALK 1664 + + + + + ++E LQ +I L L + +E ERV E++ Sbjct: 619 FSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEY----NERVRTLEMD--- 671 Query: 1665 QLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYAL 1724 RE L E+RN + + EVE Q EL +K E ++ Sbjct: 672 ------RENLSVEIRNLHNVLDSKSV---EVETQKLAYMELQQKAE-----------FSD 711 Query: 1725 QKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVH 1784 QK + + L+ + T VE+ H L +L + +E E+ Sbjct: 712 QKHQKEIENMCLKTSQLTGQVEDL--EHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKS 769 Query: 1785 EEHTRVTDESIPS--YSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEID--PENE 1840 ++ + VT+E + P + + + E+G+ S+R E D P+N Sbjct: 770 KDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSER----SECRLEADQSPKNS 825 Query: 1841 ELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELR 1900 ++ N L+ ++E + S+ Q E + E+ E+ + ++ +S + R Sbjct: 826 AILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEI-EENLMKAEQMHQSFVAETSQR 884 Query: 1901 -ERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRL 1959 +L E++ A + + E A ++ E L +++ + I L++ + L Sbjct: 885 ISKLQEDTSAHQNVVAETLSA---LENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSL 941 Query: 1960 QELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQ---LLQETEKLMKEKLEVQCQAEKVR 2016 +EL+ + + E++ +S K E + Q+ L + L +EK+ + ++E Sbjct: 942 KELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESFA 1001 Query: 2017 ---DDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQA 2073 D+ +K + L +++ ++ +E DL Q+ +A +++ K+ L+E Sbjct: 1002 NYIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECT 1061 Query: 2074 I---DREHERDVFQQEIQKLEQQLKVVPRF-QPISEHQTREVEQLANHLK-EKTDKCSEL 2128 +R++E + ++ K Q+ F + +++ E+E + L+ E TD + Sbjct: 1062 SLCENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNS 1121 Query: 2129 LLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVEDRKHFGAVEAKPELSLEVQLQAERD 2188 L+++I EE K++ V +L Q E+ + ++ K E ++ + R+ Sbjct: 1122 KSEAGGLKQEIMTLKEEQNKMQKEVNDLLQ----ENEQLMKVMKTKHECQ-NLESEPIRN 1176 Query: 2189 AIDRKEKEIT--NLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLF 2246 ++ +E E N + Q++ +E+ + Q + ++ ++ KE +LQE E+E + Sbjct: 1177 SVKERESERNQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLRNKE--LKLQESEKEKECL 1234 Query: 2247 KDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEV-----EIDQLNEQVTKLQQQLK 2301 + +++ + ++ S+ Q Q + K +I E++ E+ LQ L+ Sbjct: 1235 QHELQTIRGDLETSNLQDMQSQEISGLKDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQ 1294 Query: 2302 ITTDNKVIE----------EKNELIRDL-ETQIECLMSDQECVKRNRE--EEIEQLNEVI 2348 TT NK+ E EK EL+ +L +++ EC+ + ++ + + E++ LN+ Sbjct: 1295 -TTMNKLNELEKICEILQAEKYELVTELNDSRSECITATRKMAEEVGKLLNEVKILNDDS 1353 Query: 2349 EKLQQELAN------IGQKTSMNAHSLS----EEADSLKH------QLDVVIAEKLALEQ 2392 L EL G++ + H +S +E++S +H ++ + AE L++ Sbjct: 1354 GLLHGELVEDIPGGEFGEQPN-EQHPVSLAPLDESNSYEHLTLSDKEVQMHFAE---LQE 1409 Query: 2393 QVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRER----ESVEKIQSIPENSVNVAID 2448 + + E + + + + KM++L + SLK E ++ Q + + ++ Sbjct: 1410 KFLSLQSEHKILHDQHCQMSSKMSELQTYVDSLKAENLVLSTNLRNFQGDLVKEMQLGLE 1469 Query: 2449 HLSKDKPELEVVLTEDALKSLENQTYFKSF-EENGKGSIINLETRLLQLESTVSAKDLEL 2507 V +L SL + +++++ E+ G S+++ LE VSA + Sbjct: 1470 EGLVPSLSSSCVPDSSSLSSLGDSSFYRALLEQTGDMSLLS------NLEGAVSANQCSV 1523 Query: 2508 TQCYKQIKDMQEQGQFETEMLQKK-IVNLQKIVE--EKVAAALVSQIQLEAVQEYAKFCQ 2564 + + + + ET K + L+ + E + L +++ + + + + + Sbjct: 1524 DEVFCSSLQEENLTRKETPSAPAKGVEELESLCEVYRQSLEKLEEKMESQGIMKNKEIQE 1583 Query: 2565 DNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIA 2624 Q +SSE + + L E+E +L S +EM + L EK+Q E Sbjct: 1584 LEQLLSSERQELDCLRKQYLSENEQWQQ---------KLTSVTLEMESKLAAEKKQTEQL 1634 Query: 2625 EKNVLEKEKKLLELQKL---------------LEGNE------KKQREKEKKRSPQ---- 2659 LE E L+LQ L ++G K+ + +R+P+ Sbjct: 1635 S---LELEVARLQLQGLDLSSRSLLGIDTEDAIQGRNESCDISKEHTSETTERTPKHDVH 1691 Query: 2660 -------------DVEVLKTTTELFHSNEESG---------------------FFNELEA 2685 D+E + T + + E SG +EL + Sbjct: 1692 QICDKDAQQDLNLDIEKITETGAVKPTGECSGEQSPDTNYEPPGEDKTQGSSECISEL-S 1750 Query: 2686 LRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQ---------KDLSQVRDHLAEAK 2736 + + +E LQ L VKET+ +L+ + + + + + E Sbjct: 1751 FSGPNALVPMDFLGNQEDIHNLQ--LRVKETSNENLRLLHVIEDRDRKVESLLNEMKELD 1808 Query: 2737 EKLSILEKEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGI 2796 KL + E + T+++ AC I+L K + G LK +S+ + ++ + Sbjct: 1809 SKLHLQEVQLMTKIE----AC------IELEKIV-----GELKKENSDLSEKLEYFS--- 1850 Query: 2797 QINLQSECSSEEVTEIISQFTEKIEKMQELHAAEILDMESR-----HISETETLKREHYV 2851 C +E+ + + + +E + E+HA D SR ++++ +E ++ Sbjct: 1851 -------CDHQELLQRV-ETSEGLNSDLEMHA----DKSSREDIGDNVAKVNDSWKERFL 1898 Query: 2852 AVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREICSSDSGSDWGQGIYLTHSQ 2911 V+ + KA I E ++ A + QT ++C + + I + Sbjct: 1899 DVENELSRIRSEKASI------EHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEE 1952 Query: 2912 GFDIASEG---RGE-----ESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDH 2963 + SE RGE + +A D +K+K + + + + L H Sbjct: 1953 LSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECL------------H 2000 Query: 2964 SIQQVSEPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQ 3023 IQ V+E ++E+ + T+SS + K + + ++ + ++ S + EL + Sbjct: 2001 CIQ-VAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIA 2059 Query: 3024 QVFLEERSVLLAAFRTELTALGTTD--AVGLLNCLEQRIQEQGVEYQAAMECLQKADRRS 3081 Q+ +E+ +L+ + L +D + + LE + E+G E+ + Q+ Sbjct: 2060 QLN-KEKELLVKESESLQARLSESDYEKLNVSKALEAALVEKG-EFALRLSSTQE----- 2112 Query: 3082 LLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATE 3141 E+ L + ++ ++ +++ + E L+ E + E S+KD+ Sbjct: 2113 ---EVHQLRRGIEKLRVRIEADEKKQLHIAEKLK-----------ERERENDSLKDKVEN 2158 Query: 3142 LQE--QLSSEKMVVAELKSELAQTKLELETTLKAQHKHL-KELEAFRLEVKDKTDEVHLL 3198 L+ Q+S E + L +E ++ ++E TLK Q + + + L+ F L++ E L Sbjct: 2159 LERELQMSEENQELVILDAENSKAEVE---TLKTQIEEMARSLKVFELDLVTLRSEKENL 2215 Query: 3199 NDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQ 3258 + +Q + EL L K+ L E+ + + E+ K ++E + + +LN + Sbjct: 2216 TKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELN----EA 2271 Query: 3259 KQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQL 3318 L Q+ +++ D + EE Q+ EK+R R D +++L Sbjct: 2272 VAALCGDQEIMKATEQSLDPPIEEEH------QLRNSIEKLRAR---LEADEKKQLCVLQ 2322 Query: 3319 QSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKY-KLDSLQTRQQMEKDRQ 3377 Q + + DLLK + LE R +E+ +++ L++ ++ ++E Sbjct: 2323 QLKESEHHA-------DLLKGRVENLE----RELEIARTNQEHAALEAENSKGEVE---- 2367 Query: 3378 VHRKTLQTEQEANTEGQKKMH----ELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQ 3433 TL+ + E T+ + + ++S+ E+L +L+++++++ +L++ + I+Q Sbjct: 2368 ----TLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQ 2423 Query: 3434 EFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEM 3493 E ++++++ +EK + + Q +L E+ Sbjct: 2424 EKEQEKVQMKEKSSTAMEMLQ---------------------------------TQLKEL 2450 Query: 3494 NGGGTGCNHELEMIRQKLQCVASKLQVLPQKASERLQFETADDEDFIWVQENIDEIILQL 3553 N +++ E + K Q ++S+++ L + ++ LQ ++I +Q +++ +I ++ Sbjct: 2451 NERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEV 2510 Query: 3554 QKLTGQQGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKLEEQIR 3613 + + ++ +S + E+L+ + +++ G E+ +LRN+ ++LE++I+ Sbjct: 2511 EDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQ 2570 Query: 3614 WYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRAEAEVYKLKAEL 3672 + A ++ + N+E +E E+ +K++ + + + A+ +L+ E+ Sbjct: 2571 VLQSKNASLQDTLEVLQSSYKNLE----NELELTKMDKMSFVEKVNKMTAKETELQREM 2625 Score = 188 bits (478), Expect = 8e-47 Identities = 590/3024 (19%), Positives = 1196/3024 (39%), Gaps = 448/3024 (14%) Query: 668 DGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDL----QQSLVNSKSEEMTLQINE 723 +GL QKI+ ++ + D L ++ Q ++ L+ +Q + N K+E L+ E Sbjct: 10 EGLPTRALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLK-RE 68 Query: 724 LQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDE 783 Q+ +EI EK K + E+Q + + E Q+ + +++ +L+ S L+ Sbjct: 69 NQRLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERS 128 Query: 784 KKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEI 843 ++ + P + +++ S+ + EDLK++ N+E+ Sbjct: 129 QQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSG----------SKYEDLKEK---YNKEV 175 Query: 844 EKQRNTFSFAEKNFEVNYQELQEEYA------CLLKVKDDLEDSKNKQELEYKSKLKALN 897 E++ K E + LQ + A + +D + ++ + + Sbjct: 176 EER--------KRLEAEVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSH 227 Query: 898 EELHLQRINPTTVKMKSSVF--DEDKTFVAETLEMGEVVEK----DTTELMEKLEVTKRE 951 + QR P +S F +++ T TL++G+ D + L+ K + Sbjct: 228 LSSNSQR-TPIRRDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQ 286 Query: 952 KLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQS 1011 EL ++++L +L+ E+ + + L+ + E+ + E E ++N R E V++ Sbjct: 287 NQELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRT 346 Query: 1012 ------CDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEES 1065 T+ ++L + +T + S + N E ++ +E K+ + EE Sbjct: 347 TAQYDQASTKYTALEQKLKKLTE---DLSCQRQN---AESARCSLEQKIKEKEKEFQEEL 400 Query: 1066 KQEQLILDHLPSVTKESSLRATQPSENDK-----LQKELNVLKSEQNDLRLQMEA--QRI 1118 ++Q L + R TQ + K LQ EL+ L S + L +E Q++ Sbjct: 401 SRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKL 460 Query: 1119 CLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETG 1178 C + Q + ENE +++ +K+E + ++ +++ LE + ++ Sbjct: 461 CRA----EQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCL 516 Query: 1179 DEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPAL--KCEVNAEDKENSGDYISE 1236 ++ + + KA + L+ L + + K ++ D E D Sbjct: 517 NQSQNF----AEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQRDCS-- 570 Query: 1237 NEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEEN 1296 QD + + E ++ L+K TE+ +K L+ L K E+ E Sbjct: 571 ------QDLLKKREHHIEQLNDKLSK-TEKESKALLSALELKK----------KEY--EE 611 Query: 1297 LPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKE 1356 L +E+T F S+ KL + + EK L+ ++ LE+ + + QQ+K Sbjct: 612 LKEEKTLFSCWKSE-----------NEKLLTQMESEKENLQSKINHLETCLKT--QQIKS 658 Query: 1357 TEQNYEAEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEF 1416 E N + + +V + L SV E + Q+ Y + EF Sbjct: 659 HEYNERVRTLEMDRENLSVEIRNLHNVLDSKSV---EVETQKLAY------MELQQKAEF 709 Query: 1417 SGEFGVKEETNIVKLLEKQYQEQLEEEVAKV-IVSMSIAFAQQT--ELSRISGGKENTAS 1473 S + KE N+ L Q Q+E+ K+ ++S I + +L + Sbjct: 710 SDQKHQKEIENMC-LKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLK 768 Query: 1474 SKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNS 1533 SK A V E H + + Q +F + +GE G S Sbjct: 769 SKDASLVTN-EDHQRSLLAFDQQPAMHHSFANI--------------IGEQG-------S 806 Query: 1534 DPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQE 1593 P E +C L E K + Q+ D + S +++ +Q+ L+ +E Sbjct: 807 MPS---ERSECRL----EADQSPKNSAILQNRVDSLEFS-LESQKQM---NSDLQKQCEE 855 Query: 1594 LVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQR-SSIDNE------ 1646 LV+ E ++ Q H + + +LQE+ +A+ S+++N+ Sbjct: 856 LVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQL 915 Query: 1647 -NLVSERERVLLEEL--------EALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVEE 1697 N E E+ ++EL ++LK+L L E L E + S+ E+ + Sbjct: 916 LNDKVETEQAEIQELKKSNHLLEDSLKELQLLS-ETLSLEKKEMSSIISLNKREIEELTQ 974 Query: 1698 QTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGIL 1757 + KE++ L+ E+ L + + + E K+ + + + + L +L Sbjct: 975 ENGTLKEINAS--------LNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILL 1026 Query: 1758 DRSSKSQSSASLIWRSEAEASVKS----CVHEEHTRVTDESIPSYSGSDMPRNDINMWSK 1813 R ++ ++ + + A K+ C+ E T + + +N++ + Sbjct: 1027 QRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENR----------KNELEQLKE 1076 Query: 1814 VTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKV 1873 + E + L + FA + N+ LML + + QA ++ + + + S+ K Sbjct: 1077 AFAK--EHQEFLTKLAFA----EERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQ 1130 Query: 1874 TQTELMRESFRQKQEATESLKCQEEL----------------------RERLHEESRARE 1911 L E + ++E + L+ E+L +ER E ++ Sbjct: 1131 EIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKERESERNQCNF 1190 Query: 1912 QLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQ----ELEAEQQ 1967 + ++L E +D Y + E ++ K + E+E C + LQ +LE Sbjct: 1191 KPQMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLETSNL 1250 Query: 1968 QIQEERELLSRQKEAMKAE----AGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQV 2023 Q + +E+ + + AE +GP E Q + +QC + + L + Sbjct: 1251 QDMQSQEISGLKDCEIDAEEKYISGPHELSTSQN------DNAHLQCSLQTTMNKLNELE 1304 Query: 2024 KALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAI-DREHERDV 2082 K EI E+ EL ++ + R+ + + K L +++ D+ + E D+ Sbjct: 1305 KICEILQAEKYELVTELNDSRSECITATRKMAEEVGKLLNEVKILNDDSGLLHGELVEDI 1364 Query: 2083 FQQEI--QKLEQQ-LKVVPRFQPIS-EHQTREVEQLANHLKEKTDKCSELLLSKEQLQRD 2138 E Q EQ + + P + S EH T +++ H E +K L + L Sbjct: 1365 PGGEFGEQPNEQHPVSLAPLDESNSYEHLTLSDKEVQMHFAELQEKFLSLQSEHKILHDQ 1424 Query: 2139 IQERNEEIEKLEFRVREL--EQALLVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKE 2196 + + ++ +L+ V L E +L + ++F + +L E+QL E + Sbjct: 1425 HCQMSSKMSELQTYVDSLKAENLVLSTNLRNF-----QGDLVKEMQLGLEEGLVPSLSSS 1479 Query: 2197 ITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLA 2256 L + + Q M L + E + + ++F +++ L Sbjct: 1480 CVPDSSSLSSLGDSSFYRALLEQTGDMSL-LSNLEGAVSANQCSVD-EVFCSSLQEENLT 1537 Query: 2257 IKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKIT--TDNKVIEEKNE 2314 KE+ + A+ ++E E + + + KL+++++ NK I+E + Sbjct: 1538 RKETPSAP-----------AKGVEELESLCEVYRQSLEKLEEKMESQGIMKNKEIQELEQ 1586 Query: 2315 LIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEAD 2374 L+ +++CL ++ + N + + ++L V +++ +LA +K SL E Sbjct: 1587 LLSSERQELDCLR--KQYLSENEQWQ-QKLTSVTLEMESKLA--AEKKQTEQLSLELEVA 1641 Query: 2375 SLKHQ-LDVVIAEKLAL--EQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERES 2431 L+ Q LD+ L + E ++ NE K ET + + K ++ Sbjct: 1642 RLQLQGLDLSSRSLLGIDTEDAIQGRNESCDISKEHTSETTERTPKHDVHQICDKDAQQD 1701 Query: 2432 ----VEKI----------QSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKS 2477 +EKI + E S + + +DK + + S N Sbjct: 1702 LNLDIEKITETGAVKPTGECSGEQSPDTNYEPPGEDKTQGSSECISELSFSGPNALVPMD 1761 Query: 2478 FEENGKGSIINLETRL-------LQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQK 2530 F N + I NL+ R+ L+L + +D ++ ++K++ + + L Sbjct: 1762 FLGNQE-DIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQEVQLMT 1820 Query: 2531 KI---VNLQKIVEE--KVAAALVSQIQLEAV--QEYAKFCQDNQTISSEPERTNIQNLNQ 2583 KI + L+KIV E K + L +++ + QE + + ++ ++S+ E + ++ Sbjct: 1821 KIEACIELEKIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLE----MHADK 1876 Query: 2584 LREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLL- 2642 +++G +++ + E V + + EK +E E LE + ++++ +KL Sbjct: 1877 SSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKASIE-HEALYLEADLEVVQTEKLCL 1935 Query: 2643 -EGNEKKQR--------------EKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALR 2687 + NE KQ+ E+ + R D KTT S + ELE+ + Sbjct: 1936 EKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQ 1995 Query: 2688 AESV-ATKAELASYKEKAEKLQ------EELLVKETNMT----SLQKDLSQVRDHLAEAK 2736 +E + + A KEK E LQ ELL +T++ SL+KD + E + Sbjct: 1996 SECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELE 2055 Query: 2737 EKLSILEKEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGI 2796 +++ L KE E V+ES E L +LS+S K++ S LV+ Sbjct: 2056 NQIAQLNKEKELLVKES------ESLQARLSESDYE------KLNVSKALEAALVEKGEF 2103 Query: 2797 QINLQSECSSEEVTEI---ISQFTEKIE--KMQELHAAEILDMESRHIS----ETETLKR 2847 + L S + EEV ++ I + +IE + ++LH AE L R + E L+R Sbjct: 2104 ALRLSS--TQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLER 2161 Query: 2848 EHYVAVQ---LLKEECGTLKAVIQCLRSKEGSSIPELAHS-DAYQTREICSSDSGSDWGQ 2903 E ++ + L+ + KA ++ L+++ I E+A S ++ + + + Sbjct: 2162 ELQMSEENQELVILDAENSKAEVETLKTQ----IEEMARSLKVFELDLVTLRSEKENLTK 2217 Query: 2904 GIYLTHSQGFDI-----ASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYS 2958 I Q ++ + + EE E A ++ K + + N Q+ L E+ + Sbjct: 2218 QIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQN---QLKELNEAVAA 2274 Query: 2959 DGEDHSIQQVSE----PWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDW 3014 D I + +E P +EE N+I L+ +++ + ++ Q ES + Sbjct: 2275 LCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLR---ARLEADEKKQLCVLQQLKES--EH 2329 Query: 3015 RGELLLALQQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQE-----QGVEYQA 3069 +LL +V ER + +A E AL ++ G + L+ +I+ +G+E Sbjct: 2330 HADLLKG--RVENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDV 2387 Query: 3070 AMECLQKADRRSLLSEIQALHAQMNGRKI------TLKREQESEK--------PSQELLE 3115 ++++ +L +E+Q +++ +I + +E+E EK + E+L+ Sbjct: 2388 VTI---RSEKENLTNELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQ 2444 Query: 3116 YNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQH 3175 +++ ++ + + + K + L Q+ ++ A+L L + K + + Sbjct: 2445 TQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVN 2504 Query: 3176 KHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELE 3235 ++E+E + +++ K +E+ L + + +++ +L + + +L + + EL Sbjct: 2505 GLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQV--EGEHQLWKEQNL---ELR 2559 Query: 3236 DLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQ-------RMLYDAQLSEEQGRNL 3288 +L LE + Q N L+ ++L S + +E++ +M + ++++ + Sbjct: 2560 NLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKET 2619 Query: 3289 ELQVLLESEKVRIREMSSTLDRER-----ELHAQLQSSDGTGQSRPPLPSEDLLKELQKQ 3343 ELQ + + E+ L E+ EL L+ + L E+ EL+K Sbjct: 2620 ELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELTLEN--SELKKS 2677 Query: 3344 LEEKHSRIVEL--------------LNETEK-YKLDSLQTRQQMEKDRQVHRKTLQTEQE 3388 L+ H VE L+E EK ++ L T +Q E + Q +R+ L +++E Sbjct: 2678 LDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKLTSKEE 2737 Query: 3389 ANTEGQKKMHELQSKVEDLQRQLEEKRQ--------------QVYKLDLEGQRLQGIMQE 3434 + + ++ L+S E+L L+ Q V +L E +R QG M+ Sbjct: 2738 CLSSQKLEIDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKENERAQGKMKL 2797 Query: 3435 FQKQELEREEKRESRRILYQNLNE 3458 K + EE++E IL + L++ Sbjct: 2798 LIKSCKQLEEEKE---ILQKELSQ 2818 Score = 151 bits (381), Expect = 1e-35 Identities = 333/1716 (19%), Positives = 699/1716 (40%), Gaps = 253/1716 (14%) Query: 1976 LSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVS 2035 L KE + A Q+L + +KL KEK + Q Q + + LQKQ + +E + E + Sbjct: 5 LEEWKEGLPTRALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTN 64 Query: 2036 RFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLK 2095 + +N LM++ + + ++++ + + Q +E + + +++I+KLEQ+LK Sbjct: 65 L-----KRENQRLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELK 119 Query: 2096 VVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLS------------KEQLQRDIQERN 2143 S+ + + N + L KE+ ++++ER Sbjct: 120 RCKSELERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERK 179 Query: 2144 E-EIEKLEFRVRELEQALLVEDRKHFGAVEAKPELSL----------EVQLQAERDAIDR 2192 E E + ++ Q L H + S+ + ++R I R Sbjct: 180 RLEAEVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRR 239 Query: 2193 K--------EKEITNLEEQLEQFREELENK---NEEVQQLHMQLEIQKKESTTRLQEL-- 2239 E+E+T L+ + + + N L QL+ Q +E ++ EL Sbjct: 240 DFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELEL 299 Query: 2240 -----EQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVT 2294 E+E K + ++L L ++++ + + VL K + + DQ + + T Sbjct: 300 RLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVL-NKCRDELVRTTAQYDQASTKYT 358 Query: 2295 KLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQE 2354 L+Q+LK T++ + +N +E + ++E + +EE+ + + L QE Sbjct: 359 ALEQKLKKLTEDLSCQRQN--AESARCSLEQKIKEKE---KEFQEELSRQQRSFQTLDQE 413 Query: 2355 LANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFK 2414 + + + + L+ +LD + + K LE +E +++ + + + K Sbjct: 414 CIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIK 473 Query: 2415 MNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTY 2474 N+L + + +K+E N + + +++ LE L +K NQ+ Sbjct: 474 ENELRRSMEEMKKE-----------NNLLKSHSEQKAREVCHLEAELKN--IKQCLNQS- 519 Query: 2475 FKSFEENGKGSIINLETRLLQLESTVSAKD--LELTQCYKQIKDMQEQGQFETEMLQKKI 2532 ++F E K + ET L L+ ++ ++ L L + + D+++Q ++L+K+ Sbjct: 520 -QNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKRE 578 Query: 2533 VNLQKIVE-----EKVAAALVSQIQLEAVQEYAKFCQDNQTIS------------SEPER 2575 +++++ + EK + AL+S ++L+ +EY + ++ S E E+ Sbjct: 579 HHIEQLNDKLSKTEKESKALLSALELKK-KEYEELKEEKTLFSCWKSENEKLLTQMESEK 637 Query: 2576 TNIQN----------LNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAE 2625 N+Q+ Q++ E + L + L ++ +H +L+ + VE+ Sbjct: 638 ENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHN--VLDSKSVEVET 695 Query: 2626 KNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFH-----SNE----- 2675 + + +ELQ+ E +++K +++ + + ++ +L H SNE Sbjct: 696 QKL-----AYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKD 750 Query: 2676 --ESGFFNELEALRAESVATKAELASYKEKAEKL-----QEELLVKETNMT----SLQKD 2724 E E+LR + A L + ++ L Q + N+ S+ + Sbjct: 751 RCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSE 810 Query: 2725 LSQVRDHLAEAKEKLSILE-KEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSS 2783 S+ R ++ + +IL+ + D E + M L + + + + + + + Sbjct: 811 RSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKA 870 Query: 2784 NQTPQILVKNAGIQIN-LQSECSSEE--VTEIISQFTEKIEKMQ------ELHAAEILDM 2834 Q Q V +I+ LQ + S+ + V E +S K +++Q E AEI ++ Sbjct: 871 EQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQEL 930 Query: 2835 -ESRH-----------ISETETLKREHYVA--------VQLLKEECGTLKAVIQCLRSKE 2874 +S H +SET +L+++ + ++ L +E GTLK + L ++ Sbjct: 931 KKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEK 990 Query: 2875 GSSIPEL-AHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESESATDSFPK 2933 + I + + ++ RE S+ + Q + R EE+ +A + + Sbjct: 991 MNLIQKSESFANYIDEREKSISELSDQYKQEKLILLQ---------RCEETGNAYEDLSQ 1041 Query: 2934 KIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINTISSLKDLITKM 2993 K K N ++ L + + + ++Q+ E + +E + ++ ++ ++ + Sbjct: 1042 KYKAAQE--KNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQNL 1099 Query: 2994 QLQRE-------AEVYDSSQSHESFSDWRGELLLALQQV----------FLEERSVLLAA 3036 L+ E +E+ D+ + +S + + ++ L++ L+E L+ Sbjct: 1100 MLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKV 1159 Query: 3037 FRTELTALGTTDAVGLLNCLEQRIQEQG-VEYQAAMEC-LQKADRRSLLSEIQALHAQMN 3094 +T+ ++ + N +++R E+ ++ M+ +++ S +++ L A + Sbjct: 1160 MKTK-HECQNLESEPIRNSVKERESERNQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLR 1218 Query: 3095 GRKITLKREQESEKPSQELLEYNIQQ-----KQSQMLEMQ-VELSSMKDRATELQEQLSS 3148 +++ L QESEK +E L++ +Q + S + +MQ E+S +KD + +E+ S Sbjct: 1219 NKELKL---QESEK-EKECLQHELQTIRGDLETSNLQDMQSQEISGLKDCEIDAEEKYIS 1274 Query: 3149 EKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDT----LAS 3204 ++ +++ A + L+TT+ ++ K E + E K + V LND+ + + Sbjct: 1275 GPHELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQAE---KYELVTELNDSRSECITA 1331 Query: 3205 EQKKSRELQWALEKEKAKLGRSEERDKEELEDL---KFSLESQKQRNLQLN--------- 3252 +K + E+ L + K S E +ED+ +F + +Q + L Sbjct: 1332 TRKMAEEVGKLLNEVKILNDDSGLLHGELVEDIPGGEFGEQPNEQHPVSLAPLDESNSYE 1391 Query: 3253 --LLLEQQKQL----LNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSS 3306 L +++ Q+ L E ++S+ + Q + + ELQ ++S K +S+ Sbjct: 1392 HLTLSDKEVQMHFAELQEKFLSLQSEHKILHDQHCQMSSKMSELQTYVDSLKAENLVLST 1451 Query: 3307 TL-----DRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKY 3361 L D +E+ L+ S +P L L S LL +T Sbjct: 1452 NLRNFQGDLVKEMQLGLEEGLVPSLSSSCVPDSSSLSSLGDS-----SFYRALLEQTGDM 1506 Query: 3362 KLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKL 3421 L S V + QE N ++ VE+L+ E RQ + KL Sbjct: 1507 SLLSNLEGAVSANQCSVDEVFCSSLQEENLTRKETPSAPAKGVEELESLCEVYRQSLEKL 1566 Query: 3422 DLEGQRLQGIMQEFQKQELER---EEKRESRRILYQNLNEPTTW--SLTSDRTRNWVLQQ 3476 + E QGIM+ + QELE+ E++E + Q L+E W LTS ++ Sbjct: 1567 E-EKMESQGIMKNKEIQELEQLLSSERQELDCLRKQYLSENEQWQQKLTSVTLE---MES 1622 Query: 3477 KIEGETKESNYAKLIEMNGGGTGCNHELEMIRQKLQ 3512 K+ E K++ L ELE+ R +LQ Sbjct: 1623 KLAAEKKQTEQLSL------------ELEVARLQLQ 1646 Score = 140 bits (354), Expect = 2e-32 Identities = 352/1811 (19%), Positives = 724/1811 (39%), Gaps = 248/1811 (13%) Query: 4 EERQKKLEAGKAKLAQFR---QRKAQSDGQSPSKKQKKKRKTSSSKHDVSAHHDLNIDQS 60 +E +K+ E + +L R + D QS K + + + +S H+L+ Q Sbjct: 1225 QESEKEKECLQHELQTIRGDLETSNLQDMQSQEISGLKDCEIDAEEKYISGPHELSTSQ- 1283 Query: 61 QCNEMYINSSQRVESTVIPESTIMRTLHSGEITSHEQGFSVELESEISTTADDCSSEVNG 120 N + ++ ++ ++T+ + +I Q EL +E++ + +C + Sbjct: 1284 -------NDNAHLQCSL--QTTMNKLNELEKICEILQAEKYELVTELNDSRSECITATR- 1333 Query: 121 CSFVMRTGKPTNLLREEEFGVDDS---------------YSEQGAQDSPTHLEMMESELA 165 GK LL E + DDS + EQ + P L ++ Sbjct: 1334 -KMAEEVGK---LLNEVKILNDDSGLLHGELVEDIPGGEFGEQPNEQHPVSLAPLD---- 1385 Query: 166 GKQHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGII----TQLTANLQQARREK 221 + + E L +E+++ + +LQE +++ I+ Q+++ + + + Sbjct: 1386 -ESNSYEHLTLSDKEVQMHFA-----ELQEKFLSLQSEHKILHDQHCQMSSKMSELQTYV 1439 Query: 222 DETMREFLELTEQSQKLQ---IQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLE 278 D E L L+ + Q ++ QL E L S SS D L+ Sbjct: 1440 DSLKAENLVLSTNLRNFQGDLVKEMQLGLEEGLVPSLSSSCVPD-----SSSLSSLGDSS 1494 Query: 279 EQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEE-IQEKETIIEELNTK 337 LLE + D ++ +S L+ + + D+ +S +EE + KET K Sbjct: 1495 FYRALLE----QTGDMSL-LSNLEGAVSANQCSVDEVFCSSLQEENLTRKET--PSAPAK 1547 Query: 338 IIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQL 397 +EE + E+ + + +KL +++ Q + KN+EI+ ++ +L +S+++E KQ Sbjct: 1548 GVEELESLCEVYRQ--SLEKLEEKMESQGIMKNKEIQELE-QLLSSERQELDCLR--KQY 1602 Query: 398 MGTVEELQKRNHKDSQFETDIVQRMEQET---QRKLEQLRAELDEMYGQQIVQMKQELIR 454 + E+ Q++ T + ME + +++ EQL EL+ + +++ + + Sbjct: 1603 LSENEQWQQKL-------TSVTLEMESKLAAEKKQTEQLSLELE------VARLQLQGLD 1649 Query: 455 QHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIK--LQDTNSQKEKL 512 + + T + N S +E + ++++ K QD N EK+ Sbjct: 1650 LSSRSLLGIDTEDAIQGRNESCDISKEHTSETTERTPKHDVHQICDKDAQQDLNLDIEKI 1709 Query: 513 KEELGLILEEKCALQRQLE---------------DLVEELSFSREQIQRARQTIAEQES- 556 E + +C+ ++ + + + ELSFS + QE Sbjct: 1710 TETGAVKPTGECSGEQSPDTNYEPPGEDKTQGSSECISELSFSGPNALVPMDFLGNQEDI 1769 Query: 557 ---------KLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEK 607 NE + L +ED ++ S KEL+ K + K+E + + Sbjct: 1770 HNLQLRVKETSNENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIEACIELE 1829 Query: 608 NAVLDRMAE----SQEAELERLRTQLLFSHEEELSKLKEDLEIE-HRINIEKLKDNLGI- 661 V + E S++ E Q L E L DLE+ + + E + DN+ Sbjct: 1830 KIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSREDIGDNVAKV 1889 Query: 662 --HYKQQIDGLQNEMSQ--------KIETMQFEKDNLITKQNQLILEISKLKDLQQSLVN 711 +K++ ++NE+S+ + E + E D + + +L LE K + +Q ++ Sbjct: 1890 NDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLCLE--KDNENKQKVIV 1947 Query: 712 SKSEEM---TLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQE 768 EE+ T + N+L+ E++ + K+ L+Q ++++ KT+ LE E + +Q Sbjct: 1948 CLEEELSVVTSERNQLRGELDTM---SKKTTALDQLSEKMKEKTQELESHQSECLHCIQV 2004 Query: 769 KFAQLEAENSILKDEKKTLEDMLKIHT-------PVSQEERLIFLDSIKSKSKDSVWEKE 821 A+++ + +L+ + ++LK T + ++ + + L + +++ + KE Sbjct: 2005 AEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKE 2064 Query: 822 IEILIEENEDLKQQCIQLNEE---IEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDL 878 E+L++E+E L+ + + + E + K + F + QEE L + + L Sbjct: 2065 KELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKL 2124 Query: 879 E---DSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMG---- 931 ++ K++L KLK E + ++ + + +E++ V E Sbjct: 2125 RVRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQELVILDAENSKAEV 2184 Query: 932 EVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNE---EVKSLKQEKE 988 E ++ E+ L+V + + + L +L++Q+++K G++S L++ KSL +EKE Sbjct: 2185 ETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKE 2244 Query: 989 QVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKI 1048 Q EI I V+ Q+ L + V + ++ + E + Sbjct: 2245 QA-------EIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEH 2297 Query: 1049 MVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRA-TQPSENDKLQKELNVLKSEQN 1107 + + + + + K++ +L L KES A + L++EL + ++ Q Sbjct: 2298 QLRNSIEKLRARLEADEKKQLCVLQQL----KESEHHADLLKGRVENLERELEIARTNQE 2353 Query: 1108 DLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQL 1167 L+ E + + + + + E D + +++ E E KE ++I +L Sbjct: 2354 HAALEAENSKGEVETLKAKIEGMTQSLRGLELD--VVTIRSEKENLTNELQKEQERISEL 2411 Query: 1168 ELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDK 1227 E+ + E + + + K S LQT L E + + K Sbjct: 2412 EIINSSFENILQEKEQEKVQM----KEKSSTAMEMLQTQLKELNERVAALHNDQEACKAK 2467 Query: 1228 ENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDG 1287 E Q+ +V+ + LL + E N +VLQ+ ++ + + DG Sbjct: 2468 E--------------QNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDG 2513 Query: 1288 -MKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLE----KTKLEEQVQE 1342 KLE +E + + + + ++ L ++ H +L Q+LE +LE+++Q Sbjct: 2514 KQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEH--QLWKEQNLELRNLTVELEQKIQV 2571 Query: 1343 LESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYP 1402 L+S +SLQ L+ + +Y+ L+ L+ + V+ + E++ QR M+ Sbjct: 2572 LQSKNASLQDTLEVLQSSYKN----LENELELTKMDKMSFVEKVNKMTAKETELQREMH- 2626 Query: 1403 GSCVKKNIDGTIEFSGEFG-VKEETNIVKLLEKQYQEQLEE---EVAKVIVSMSIAFAQQ 1458 +K + E SGE + E ++ K ++QL+E E +++ S+ Q Sbjct: 2627 -EMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQ 2685 Query: 1459 TELSRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVK---FKEEFK 1515 E KE + A + Q +E + + T + +V+ ++E+ Sbjct: 2686 VE-------KEGKVREEIA-----EYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKLT 2733 Query: 1516 PLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMD 1575 + L EI L S ++ S I EE+ + + ++ Sbjct: 2734 SKEECLSSQKLEIDLLKSSKEELNNSLKATTQILEEL--------------KKTKMDNLK 2779 Query: 1576 ASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQ----------EQ 1625 QL E+ + + L++ ++ ++ E+L Q + Q++ +E Q ++ Sbjct: 2780 YVNQLKKENERAQGKMKLLIKSCKQLEEEKEIL-QKELSQLQAAQEKQKTGTVMDTKVDE 2838 Query: 1626 LQEEIKRLNRQLAQRSSIDNENLVSERERVLL-EELEALKQLSLAGREKLCCELRNSSTQ 1684 L EIK L L +++ +E L ++ E+LE K++ LC + S Q Sbjct: 2839 LTTEIKELKETLEEKTKEADEYLDKYCSLLISHEKLEKAKEMLETQVAHLCSQ---QSKQ 2895 Query: 1685 TQNGNENQGEV 1695 G+ G V Sbjct: 2896 DSRGSPLLGPV 2906 Score = 48.9 bits (115), Expect = 1e-04 Identities = 101/531 (19%), Positives = 208/531 (39%), Gaps = 88/531 (16%) Query: 3212 LQWALEKEKA------------------KLGRSEERDKEELEDLKFSLESQKQ-----RN 3248 + WALE+ K KL + +++ + +L+ L+ +L+ QKQ + Sbjct: 1 MSWALEEWKEGLPTRALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKT 60 Query: 3249 LQLNLLLEQQK-----QLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIRE 3303 NL E Q+ + L +++QKI + + ++Q++ ++G+ + +E + ++ Sbjct: 61 EGTNLKRENQRLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKR 120 Query: 3304 MSSTLDRERELHAQLQSSD------GTGQ---SRPPLPSEDLLKELQKQLEEKHSRIVEL 3354 S L+R ++ QS+D T Q + P PS+ + L+EK+++ VE Sbjct: 121 CKSELERSQQ---AAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVE- 176 Query: 3355 LNETEKYKLDS-LQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEE 3413 E+ +L++ ++ Q + + + + T+ A + + Q + Sbjct: 177 ----ERKRLEAEVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNS 232 Query: 3414 KRQQVYKLDLEGQRLQGIMQEFQKQELEREEKRESRRILYQNLNEP---TTWSLTSDRTR 3470 +R + + D G + + + KR++ + N + P + R Sbjct: 233 QRTPI-RRDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELR 291 Query: 3471 NWV--LQQKIEGETKESN----------------YAKLIEMNGGGTGCNHELEMIRQKLQ 3512 N + L+ +++G KE +LIE C EL + Sbjct: 292 NKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYD 351 Query: 3513 CVASKLQVLPQKASERLQFETADDEDFIWVQENIDEIILQL-QKLTGQQGE-EPSLVSPS 3570 ++K L QK + ED ++N + L QK+ ++ E + L Sbjct: 352 QASTKYTALEQKLKKL-------TEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQ 404 Query: 3571 TSCGSLTERLLRQNAELTGHISQ-------LTEEKNDLRNMVMKLEEQIRWYRQTGAGRD 3623 S +L + ++ A LT + Q L E + L ++ +LE + ++Q + Sbjct: 405 RSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAE 464 Query: 3624 NSSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRAEAEVYKLKAELRN 3674 + + S E + E +E L+ ++ EV L+AEL+N Sbjct: 465 QAFQAS----QIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKN 511 Score = 48.9 bits (115), Expect = 1e-04 Identities = 124/624 (19%), Positives = 262/624 (41%), Gaps = 88/624 (14%) Query: 3127 EMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKEL----- 3181 E++ +L +K + Q QL S + + + K ++ K E T LK +++ L E+ Sbjct: 22 ELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTE-GTNLKRENQRLMEICESLE 80 Query: 3182 ---EAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLK 3238 + E++ K +V+ L S +K+ +L+ L++ K++L RS++ + D+ Sbjct: 81 KTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERSQQ--AAQSADVS 138 Query: 3239 FSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEK 3298 + + Q+ L Q S K E + Y+ ++ E + E++ L+++K Sbjct: 139 LNPCNTPQKIFTTPLTPSQY-----YSGSKYEDLKEKYNKEVEERKRLEAEVKA-LQAKK 192 Query: 3299 VRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNET 3358 +T++ Q SS + Q +EK + ++ Sbjct: 193 ASQTLPQATMNHRDIARHQASSSVFSWQ------------------QEKTPSHLSSNSQR 234 Query: 3359 EKYKLDSLQTRQQMEKDRQVHRKTLQT-EQEANT---EGQKKMHELQSKVEDLQRQLEEK 3414 + D + E++ R TLQ +++AN+ + H L + L+ Q +E Sbjct: 235 TPIRRDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLL----DQLKAQNQEL 290 Query: 3415 RQQVYKLDLEGQ----RLQGIMQEFQKQELEREEKR----ESRRILYQNLNE--PTTWSL 3464 R ++ +L+L Q ++G + +FQ+ +L+ E+ + E ++L + +E TT Sbjct: 291 RNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQY 350 Query: 3465 TSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHEL-----------EMIRQKLQC 3513 T+ L+QK++ T++ + + N C+ E E+ RQ+ Sbjct: 351 DQASTKYTALEQKLKKLTEDLSCQR---QNAESARCSLEQKIKEKEKEFQEELSRQQRSF 407 Query: 3514 VASKLQVLPQKASERLQFETADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSPSTSC 3573 + + KA + + A + + +Q +D++ Q+L E + + Sbjct: 408 QTLDQECIQMKARLTQELQQAKNMHNV-LQAELDKLTSVKQQLENNLEEFKQKLCRAEQA 466 Query: 3574 GSLTERLLRQNAELTGHISQLTEEKNDLRN-------MVMKLEEQIRWYRQTGAGRDNSS 3626 ++ +++N EL + ++ +E N L++ V LE +++ +Q N + Sbjct: 467 FQASQ--IKEN-ELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFA 523 Query: 3627 RFSLNGGANIEAIIASEKEVWNREK--LTLQKSLKRAEAEVYKLKAELRNDSLLQTLSPD 3684 + E ++ +E N+++ LTL+K LK A A++ K + Q L Sbjct: 524 EEMKAKNTSQETMLRDLQEKINQQENSLTLEK-LKLAVADLEKQR------DCSQDLLKK 576 Query: 3685 SEHVTLKRIYGKYLRAESFRKALI 3708 EH ++++ K + E KAL+ Sbjct: 577 REH-HIEQLNDKLSKTEKESKALL 599 >gi|71061468 centromere protein E [Homo sapiens] Length = 2701 Score = 239 bits (609), Expect = 5e-62 Identities = 511/2577 (19%), Positives = 1063/2577 (41%), Gaps = 404/2577 (15%) Query: 294 FTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLT 353 F +++ V E+ D+ + ++EI + + +EE++ + + + +L L Sbjct: 322 FASTAKYMKNTPYVNEVSTDEALLKRYRKEIMDLKKQLEEVSLETRAQAMEKDQLAQLLE 381 Query: 354 TADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQ 413 D LL ++Q + ++ + LT ++ + + + +G + +++ N+ D Sbjct: 382 EKD-LLQKVQNEKIENLTRMLVTSSSLTLQQELKAKRKRRVTWCLGKINKMKNSNYAD-- 438 Query: 414 FETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEM------KTRH 467 + +I + +T + L E+DE V + ++ + + E+ K + Sbjct: 439 -QFNIPTNITTKTHKLSINLLREIDES-----VCSESDVFSNTLDTLSEIEWNPATKLLN 492 Query: 468 KGEMENALRS----YSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEK 523 + +E+ L S Y N+ ++ +Q++ E+ +KL++ N E LE K Sbjct: 493 QENIESELNSLRADYDNLVLDYEQLRTEK---EEMELKLKEKNDLDEFEA------LERK 543 Query: 524 CALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRK 583 ++++ L+ E+S + ++ A + E++L+ + L ED ++ +S+K Sbjct: 544 TKKDQEMQ-LIHEISNLKNLVKHAEVYNQDLENELSSKVELLREKEDQIKKLQEYIDSQK 602 Query: 584 ELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKED 643 +K + + LE +E K + L T L + E E+ Sbjct: 603 LENIKMDLSYS-----LESIEDPKQ---------MKQTLFDAETVALDAKRESAFLRSEN 648 Query: 644 LEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQ----KIETMQFEKD-----NLITKQNQ 694 LE++ EK+K+ L YKQ + +Q SQ K + EK+ N ITK Sbjct: 649 LELK-----EKMKE-LATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTS 702 Query: 695 LILEISKLKDLQQSL-VNSKSEEMTLQINELQKEIEILRQEE---KEKGTLEQEVQ---- 746 LI + KDL +L + K ++ ++N+ +E E LR+E E +L EV+ Sbjct: 703 LI-DGKVPKDLLCNLELEGKITDLQKELNKEVEENEALREEVILLSELKSLPSEVERLRK 761 Query: 747 ELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFL 806 E+Q K+E L EK+ E + +L++ KT +D+ + ++ Sbjct: 762 EIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEF-- 819 Query: 807 DSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQE 866 + K+ D +E++ ++++EENE + Q+ + L++E +K ++ + QELQE Sbjct: 820 QNFKTLHMD--FEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQE 877 Query: 867 EYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAE 926 K ++ E ++++ L E+L + TV+ + ++ E E Sbjct: 878 ---------------KTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLE 922 Query: 927 TLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQE 986 ++ + D +L E L++ E Q SD+ + + L ++SLKQ Sbjct: 923 EVKTLTQEKDDLKQLQESLQI------ERDQLKSDIHDTVNMNIDTQEQLRNALESLKQH 976 Query: 987 KEQVSLRCREL--EIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVS-----KVN 1039 +E ++ ++ E+ N + EN + + G+ A+ + + K N Sbjct: 977 QETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDN 1036 Query: 1040 KSFGEESKI--MVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQK 1097 + ++ KI ++++K + M +++EQL D ++ + D+L+K Sbjct: 1037 EIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKK 1096 Query: 1098 ELNVLKSEQND-LRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEE 1156 + ++ E+N ++ + E R C L +V E ++ EK + L +++L+ QEE Sbjct: 1097 QQEIVAQEKNHAIKKEGELSRTCDRLA------EVEEKLK-EKSQQLQEKQQQLLNVQEE 1149 Query: 1157 KIKELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTP 1216 + +KI+++E +K + E H+ +L+ A +Y + + S+ E Sbjct: 1150 MSEMQKKINEIE--NLKNELKNKELTLEHMETERLELAQKLNENY--EEVKSITKERKVL 1205 Query: 1217 ALKCEVNAEDKENSGDYISENE------DPELQDYRYEVQDFQENMHTLLNKVTEEYNKL 1270 + ++++ YI E E EL+ +++ QE + L V+E+ ++ Sbjct: 1206 KELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQI 1265 Query: 1271 LVLQTRLSKIWGQQTDGMKLEFGEENLP--KEETEFLSIHSQMTNLEDIDVNHKSKLSSL 1328 + Q Q + L +E LP KE +E +++ L + S + Sbjct: 1266 INTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLAR 1325 Query: 1329 QDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSESTVPPSLPVDS 1388 ++E+ +L E+ QE + I SL ++ + T+ +L V Sbjct: 1326 IEMERLRLNEKFQESQEEIKSLTKERDNLK--------------------TIKEALEVKH 1365 Query: 1389 VVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVI 1448 +K++I T+ E K+E ++ ++ + E K++ Sbjct: 1366 ---------------DQLKEHIRETLAKIQESQSKQEQSL-------NMKEKDNETTKIV 1403 Query: 1449 VSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMK-LSQDQIGFQTFETVD 1507 M + + L RI E SK+ QE H +EMK +++++ Q Sbjct: 1404 SEMEQFKPKDSALLRIE--IEMLGLSKRL-----QESH--DEMKSVAKEKDDLQ------ 1448 Query: 1508 VKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVR----- 1562 + +E + S +L E+ KEI+ + + + + C L EE ++ + + Sbjct: 1449 -RLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEI 1507 Query: 1563 -------QSIHDEISVSSMDA-SRQLMLNEEQLEDMRQEL--VRQYQEHQQATELLRQAH 1612 ++I+D++ + ++ N +Q+ ++++++ ++Q++EH++A + Q+ Sbjct: 1508 STIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSI 1567 Query: 1613 MRQM----ERQREDQEQLQ------EEIKRLNRQLAQRSSIDNEN---LVSERERVLLEE 1659 +M R +E QE++Q EE+KR+ L EN +V++ + +E Sbjct: 1568 ESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKE 1627 Query: 1660 LEALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSN 1719 + LK ++ ++ CE+ + Q + N +E + + ++ + + Sbjct: 1628 YQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLE-------- 1679 Query: 1720 ERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASV 1779 E ++ K + L +VEET+ ++R ++ I R + Sbjct: 1680 EMRSVTKERDDL-----------RSVEETLK------VERDQLKENLRETITRDLEKQEE 1722 Query: 1780 KSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPEN 1839 VH H + E+I G + S+ T E + + + L S A D + Sbjct: 1723 LKIVHM-HLKEHQETIDKLRG---------IVSEKTNEISNMQKDLEHSNDALKAQDLKI 1772 Query: 1840 EELMLNISSRL---QAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQ 1896 +E + L Q ++KL +SE + +L + QK + K Q Sbjct: 1773 QEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNM-------------QKDLENSNAKLQ 1819 Query: 1897 EELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCAS 1956 E++ +E +A E + L K E ++QI++++ + +LE E L + Sbjct: 1820 EKI-----QELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLA 1874 Query: 1957 NRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVR 2016 +L E E + + +ER+ L R +E +K E +++ LQET+ LE+Q + Sbjct: 1875 QKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKES-LQETK---ARDLEIQQEL---- 1926 Query: 2017 DDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDR 2076 K + L + +E V + E EK ++ D+++ L+K ++++K + Sbjct: 1927 ----KTARMLSKEHKETVDKLREKISEKTIQISDIQKD---LDKSKDELQKKI------- 1972 Query: 2077 EHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQ 2136 QE+QK E QL V +S + E+EQL + + + + QL Sbjct: 1973 --------QELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLT 2024 Query: 2137 RDIQERNEEIEKLEFRVRELEQALLVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKE 2196 + + E EEI + EL + ++ L+ ERD +E Sbjct: 2025 KKLHESLEEIRIVAKERDELRR--------------------IKESLKMERDQFIATLRE 2064 Query: 2197 ITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDME---KL 2253 + + Q Q + E ++ Q L L +E +R++EL + D E +L Sbjct: 2065 MIARDRQNHQVKPEKRLLSDGQQHLTESL----REKCSRIKELLKRYSEMDDHYECLNRL 2120 Query: 2254 GLAI-KESDAMSTQDQHVLFGKFAQIIQEKEVE-----IDQLNEQVTKLQQQLK--ITTD 2305 L + KE + V +Q K +E + + + ++ ++LK ++ Sbjct: 2121 SLDLEKEIEFQKELSMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYV 2180 Query: 2306 NKVIEEKNELIRDLETQIECLMSDQECVKRNRE--EEIEQLNEVIEKLQQELANIGQKTS 2363 K+ EE++E I E M + V++ +E +I+ L + + +EL ++ + Sbjct: 2181 TKIKEEQHESINKFE------MDFIDEVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQN 2234 Query: 2364 MNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELF 2423 M+ H D + + + E QQV + +EMT T F + +L Sbjct: 2235 MDLHIEEILKDFSESEFPSIKTE----FQQVLSNRKEMTQFLEEWLNTRFDIEKLKN--- 2287 Query: 2424 SLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLT---EDALKSL--ENQTYFKSF 2478 +++E + + ++ + N + +AI + S + E ++ E LKSL +N+ FK++ Sbjct: 2288 GIQKENDRICQVNNFFNNRI-IAIMNESTEFEERSATISKEWEQDLKSLKEKNEKLFKNY 2346 Query: 2479 E----ENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVN 2534 + G+ +N T+ + S T+ +++++ + + + KI+ Sbjct: 2347 QTLKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEKIRELENSLHEAKESAMHKESKIIK 2406 Query: 2535 LQKIVE--EKVAAALVSQIQ-----LEAVQEYAKFCQDNQTISSEPERTNIQNLNQLRED 2587 +QK +E + A L +++ LE +E + QD + ++P + I++ Sbjct: 2407 MQKELEVTNDIIAKLQAKVHESNKCLEKTKETIQVLQDKVALGAKPYKEEIED------- 2459 Query: 2588 ELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEK 2647 L++ ++ + +M + EKE A K +E +K+++ +LL N + Sbjct: 2460 ----------LKMKLVKIDLEKMKNAKEFEKE--ISATKATVEYQKEVI---RLLRENLR 2504 Query: 2648 KQREKEKKRSPQDVEVLKTTTELFHSNEE------SGFFNELEA--LRAESVATKAELAS 2699 + ++ QD V+ T+ SN+ SG +A L++E + + E++ Sbjct: 2505 RSQQ------AQDTSVISEHTDPQPSNKPLTCGGGSGIVQNTKALILKSEHIRLEKEISK 2558 Query: 2700 YKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKA 2756 K+ Q E L+K+ N L + + + + KE+ E + + S K+ Sbjct: 2559 LKQ-----QNEQLIKQKN--ELLSNNQHLSNEVKTWKERTLKREAHKQVTCENSPKS 2608 Score = 225 bits (573), Expect = 8e-58 Identities = 463/2359 (19%), Positives = 989/2359 (41%), Gaps = 310/2359 (13%) Query: 155 THLEMMESELAGKQHEIEEL-----NRELEEM-RVTYGTEGLQQLQEFEAAIKQRDGIIT 208 T + ME + + E ++L N ++E + R+ + L QE +A K+R Sbjct: 366 TRAQAMEKDQLAQLLEEKDLLQKVQNEKIENLTRMLVTSSSLTLQQELKAKRKRR----- 420 Query: 209 QLTANLQQARREKDETMREFLEL----TEQSQKLQIQF-QQLQASETLRNSTHSSTAADL 263 +T L + + K+ + + T ++ KL I +++ S + S+T L Sbjct: 421 -VTWCLGKINKMKNSNYADQFNIPTNITTKTHKLSINLLREIDESVCSESDVFSNTLDTL 479 Query: 264 LQAKQQILT---HQQQLEEQ--------DHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQ 312 + + T +Q+ +E + D+L+ DY++ + + L+EK + E E Sbjct: 480 SEIEWNPATKLLNQENIESELNSLRADYDNLVLDYEQLRTEKEEMELKLKEKNDLDEFEA 539 Query: 313 DKKVENSNKEEIQEKETIIEELNTK--IIEEEKKTLELKDKLTTADKLLGELQEQIVQ-- 368 +E K++ QE + I E N K + E +L+++L++ +LL E ++QI + Sbjct: 540 ---LERKTKKD-QEMQLIHEISNLKNLVKHAEVYNQDLENELSSKVELLREKEDQIKKLQ 595 Query: 369 ---KNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQE 425 +Q+++N+K++L+ S +S E+ KQ+ T+ + + D++ E+ ++ E Sbjct: 596 EYIDSQKLENIKMDLSYS----LESIEDPKQMKQTLFDAE-TVALDAKRESAFLRSENLE 650 Query: 426 TQRKLEQLRAELDEMYGQ-QIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNIT-- 482 + K+++L +M Q+ Q + E ++ +E+ E+++A + +T Sbjct: 651 LKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEK-------ELQSAFNEITKLTSL 703 Query: 483 ----VNEDQIKLMNV--AINELNIKLQDTNSQKEKLKEELGLILEEKC------ALQRQL 530 V +D + + + I +L +L + E L+EE+ L+ E K L++++ Sbjct: 704 IDGKVPKDLLCNLELEGKITDLQKELNKEVEENEALREEVILLSELKSLPSEVERLRKEI 763 Query: 531 EDLVEELSFSREQIQRARQTIAEQESK----LNEAHKSLSTVEDLKAEIVSASESRKELE 586 +D EEL + + + +ES+ L E K+ + ++ S + + + Sbjct: 764 QDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFK 823 Query: 587 LKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQ--EAELERLRTQLLFSHEEELSKLKEDL 644 H YK+ LE E+ +++ E+Q ++ L L+T+L + +E K + Sbjct: 824 TLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTR--- 880 Query: 645 EIEHRIN-IEKLKDNLG---------IHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQ 694 E++ R+N +E+LK+ L K I + ++++T+ EKD+L Q Sbjct: 881 EVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQES 940 Query: 695 LILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTEL 754 L +E +LK VN + +L+ +E L+Q ++ TL+ ++ E + Sbjct: 941 LQIERDQLKSDIHDTVNMNIDTQ----EQLRNALESLKQHQETINTLKSKISEEVSRNLH 996 Query: 755 LEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFL----DSIK 810 +E+ E +++ Q+K ++ + + +TL +K + + Q+ ++ L + ++ Sbjct: 997 MEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQ 1056 Query: 811 SKSKDSVWEKE---------IEILIEENEDL-----------------KQQCIQLNEEIE 844 + + EKE IE+ IE E+L K I+ E+ Sbjct: 1057 QMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELS 1116 Query: 845 KQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNK-QELE-YKSKLKALNEELHL 902 + + + E+ + Q+LQE+ LL V++++ + + K E+E K++LK N+EL L Sbjct: 1117 RTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELK--NKELTL 1174 Query: 903 QRINPTTVKMKSSV---FDEDKTFVAETLEMGEV-----------------VEKDTTELM 942 + + +++ + ++E K+ E + E+ +E + Sbjct: 1175 EHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTK 1234 Query: 943 EKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIIN 1002 E+L++ E + + +L + +K +I + KS + +E++ + E E++ N Sbjct: 1235 EELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPN 1294 Query: 1003 HNRAENVQSCDTQVSSLLDGVVT---MTSRGAEGSVSKVNKSF---GEESKIMVEDKVSF 1056 Q ++ L + T T E ++N+ F EE K + +++ + Sbjct: 1295 VKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNL 1354 Query: 1057 ENMTVGEESKQEQL---ILDHLPSVTKESSLR------ATQPSENDKLQKELNVLKSEQN 1107 + + E K +QL I + L + + S + + +E K+ E+ K + + Sbjct: 1355 KTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDS 1414 Query: 1108 DLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQL 1167 L L++E + + LS D+++ + + D +E++ ++ +++KE + Sbjct: 1415 AL-LRIEIEMLGLSKRLQESHDEMKSVAKEKDD---LQRLQEVLQSESDQLKE-----NI 1465 Query: 1168 ELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDK 1227 + K ET +E K H + + ++ ++E L E T + E + Sbjct: 1466 KEIVAKHLETEEELKVAHCCLKEQEETINE----LRVNLSEKETEISTIQKQLEAINDKL 1521 Query: 1228 ENSGDYISENED-------PELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKI 1280 +N I E E+ E+Q+ E++ F+E+ + + +K+L L RL Sbjct: 1522 QNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQ-- 1579 Query: 1281 WGQQTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLE--E 1338 + + +++ E+ K E L I ++ K K S ++ + K+ Sbjct: 1580 --ESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVN 1637 Query: 1339 QVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQR 1398 + QE I L++Q + + N E I RL + + V + Sbjct: 1638 ETQEKMCEIEHLKEQFETQKLNLE-NIETENIRLTQILHENLEEMRSVTKERDDLRSVEE 1696 Query: 1399 TM-YPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQ 1457 T+ +K+N+ TI + + +EE IV + K++QE +++ I + Sbjct: 1697 TLKVERDQLKENLRETI--TRDLEKQEELKIVHMHLKEHQETIDK-------LRGIVSEK 1747 Query: 1458 QTELSRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPL 1517 E+S + E++ + +A + QE+ M L + Q ET+D K + Sbjct: 1748 TNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQ------ETID-KLRGIVSEK 1800 Query: 1518 SKELGEHGKEILLSNS----DPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSS 1573 + +L K++ SN+ ++ ++ ++T+ +++ K + + +I S Sbjct: 1801 TDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQS 1860 Query: 1574 MDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRL 1633 + S+ + N + + + L ++ L R ++ER +QL+E ++ Sbjct: 1861 LTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLER-----DQLKESLQET 1915 Query: 1634 N-RQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCE-LRNSSTQ---TQNG 1688 R L + + ++S+ + +++L REK+ + ++ S Q ++ Sbjct: 1916 KARDLEIQQELKTARMLSKEHKETVDKL----------REKISEKTIQISDIQKDLDKSK 1965 Query: 1689 NENQGEVEEQTFKEKELDRKPEDVPPEILS-NERYALQK----ANNRLLKILLEVVKTTA 1743 +E Q +++E KE +L R EDV NE L+K N + + ++ + T Sbjct: 1966 DELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTK 2025 Query: 1744 AVEETIGRHVLGILDRSSKSQSSASL-IWRSEAEASVKSCV--HEEHTRVTDESIPSYSG 1800 + E++ + +R + SL + R + A+++ + ++ +V E G Sbjct: 2026 KLHESLEEIRIVAKERDELRRIKESLKMERDQFIATLREMIARDRQNHQVKPEKRLLSDG 2085 Query: 1801 SDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEA 1860 ++ + E+ + + + L R +E+D E L +RL +EK +E Sbjct: 2086 QQ------HLTESLREKCSRIKELLKRY----SEMDDHYECL-----NRLSLDLEKEIEF 2130 Query: 1861 ISETSSQLE---HAKVTQTELMRESFRQKQEAT-ESLKCQEELRERLHEESRAREQLAVE 1916 E S +++ QT+ + + F Q + E + ++L+ L ++ +E+ Sbjct: 2131 QKELSMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHES 2190 Query: 1917 LSKAE-GVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEEREL 1975 ++K E ID +K L + I L+Q+ S L++L+ Q E+ Sbjct: 2191 INKFEMDFIDEVEKQKELLIK--------IQHLQQDCDVPSRELRDLKLNQNMDLHIEEI 2242 Query: 1976 LSRQKEAMKAEAGPVEQQLL---QETEKLMKEKLEVQCQAEKVRDDLQKQ---------- 2022 L E+ QQ+L +E + ++E L + EK+++ +QK+ Sbjct: 2243 LKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQVNNF 2302 Query: 2023 ----VKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREH 2078 + A+ + E R + +E +L L+++N+ L K + ++ L A Sbjct: 2303 FNNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPT 2362 Query: 2079 ERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRD 2138 +D + QL T ++ +L N L E + ++Q++ Sbjct: 2363 TQDNKNPHVTSRATQL------------TTEKIRELENSLHEAKESAMHKESKIIKMQKE 2410 Query: 2139 IQERNEEIEKLEFRVRELEQAL--------LVEDRKHFGAVEAKPELSLEVQLQAERDAI 2190 ++ N+ I KL+ +V E + L +++D+ GA K E+ L+ + I Sbjct: 2411 LEVTNDIIAKLQAKVHESNKCLEKTKETIQVLQDKVALGAKPYKEEIE---DLKMKLVKI 2467 Query: 2191 D-RKEKEITNLEEQLEQFREELENKNEEVQQLHMQL-EIQKKESTTRLQELEQENKLFKD 2248 D K K E+++ + +E + E ++ L L Q+ + T+ + E K Sbjct: 2468 DLEKMKNAKEFEKEISATKATVEYQKEVIRLLRENLRRSQQAQDTSVISEHTDPQPSNKP 2527 Query: 2249 DMEKLGLAI-KESDAMSTQDQHVLFGK-FAQIIQEKEVEIDQLNEQVTKLQQQLKITTDN 2306 G I + + A+ + +H+ K +++ Q+ E I Q NE ++ Q ++ + Sbjct: 2528 LTCGGGSGIVQNTKALILKSEHIRLEKEISKLKQQNEQLIKQKNELLSNNQH---LSNEV 2584 Query: 2307 KVIEEKNELIRDLETQIEC 2325 K +E+ L R+ Q+ C Sbjct: 2585 KTWKERT-LKREAHKQVTC 2602 Score = 217 bits (553), Expect = 2e-55 Identities = 477/2342 (20%), Positives = 981/2342 (41%), Gaps = 363/2342 (15%) Query: 276 QLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEK--ETIIEE 333 ++ + LL+ Y+K+ D Q+ + + + ME+D+ + ++++ +K IE Sbjct: 337 EVSTDEALLKRYRKEIMDLKKQLEEVSLETRAQAMEKDQLAQLLEEKDLLQKVQNEKIEN 396 Query: 334 LNTKIIEEEKKTLELKDKLTTADKL---LGELQEQ---------IVQKNQEIKNMKLELT 381 L ++ TL+ + K ++ LG++ + + N K KL + Sbjct: 397 LTRMLVTSSSLTLQQELKAKRKRRVTWCLGKINKMKNSNYADQFNIPTNITTKTHKLSIN 456 Query: 382 NSKQKERQSSEEIKQLMGTVEELQK---------RNHKDSQFETDIVQRMEQETQRKLEQ 432 ++ + E T++ L + N ++ + E + ++ EQ Sbjct: 457 LLREIDESVCSESDVFSNTLDTLSEIEWNPATKLLNQENIESELNSLRADYDNLVLDYEQ 516 Query: 433 LRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMN 492 LR E +EM +++K++ +E KT+ EM+ + SN+ ++ N Sbjct: 517 LRTEKEEME----LKLKEKNDLDEFEALER-KTKKDQEMQ-LIHEISNLKNLVKHAEVYN 570 Query: 493 VAI-NELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQ---RAR 548 + NEL+ K++ +++++K+ L+E Q+ LE++ +LS+S E I+ + + Sbjct: 571 QDLENELSSKVELLREKEDQIKK-----LQEYIDSQK-LENIKMDLSYSLESIEDPKQMK 624 Query: 549 QTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKN 608 QT+ + E+ +A + + L++E + E KEL ++ + ++ LE +K Sbjct: 625 QTLFDAETVALDAKRESAF---LRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKK 681 Query: 609 AVLDRMAESQEA--ELERLRT--------QLLFSHEEE--LSKLKEDLEIEHRINIEKLK 656 +D E Q A E+ +L + LL + E E ++ L+++L E N E L+ Sbjct: 682 MQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEEN-EALR 740 Query: 657 DNLGI-----HYKQQIDGLQNEMSQKIETMQF---EKDNLI-------TKQNQLILEISK 701 + + + +++ L+ E+ K E + EKD L ++ L+ EI K Sbjct: 741 EEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGK 800 Query: 702 LK-DLQQSLVNSKSEEM------TLQINELQKEIEILRQEEK---EKGTLEQEVQELQ-- 749 K DL + N KS + TL ++ QK +L + E+ E L +E Q+ Sbjct: 801 TKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSS 860 Query: 750 ---LKTELLEK--QMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVS------ 798 LKTEL K +++EK ++QE+ ++E L++ TL+ + + T ++ Sbjct: 861 LGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQT 920 Query: 799 -----------------QEERLIFLDSIKSKSKDSV-----WEKEIEILIEENEDLKQQC 836 QE I D +KS D+V ++++ +E + ++ Sbjct: 921 LEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETI 980 Query: 837 IQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLE---------DSKNKQEL 887 L +I ++ + E+N E Q++ + K K DLE D K+ + + Sbjct: 981 NTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDK-KQDLEAKNTQTLTADVKDNEII 1039 Query: 888 EYKSKLKAL-NEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLE 946 E + K+ +L E+ LQ++ + + K + + K + T+E E + EL ++ E Sbjct: 1040 EQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQE 1099 Query: 947 VTKREKL-------ELSQ---RLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRE 996 + +EK ELS+ RL+++ E+LK+K ++ +++ ++++E ++ + E Sbjct: 1100 IVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINE 1159 Query: 997 LEIIINH--NRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKV 1054 +E + N N+ ++ +T+ L ++ + +V KS +E K++ E + Sbjct: 1160 IENLKNELKNKELTLEHMETERLEL--------AQKLNENYEEV-KSITKERKVLKELQK 1210 Query: 1055 SFEN------------MTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVL 1102 SFE G ++K E+L + H+ + ++ + S ++K + +N Sbjct: 1211 SFETERDHLRGYIREIEATGLQTK-EELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQ 1269 Query: 1103 KSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQ 1162 E++ +LQ E + +V +V E E ++ E + ++ K+ Sbjct: 1270 DLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQE--------TMNELELLTEQSTTKDST 1321 Query: 1163 KIHQLELQTM----KTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPAL 1218 + ++E++ + K QE+ +E K L L K + E L+ L E+ L Sbjct: 1322 TLARIEMERLRLNEKFQESQEEIKSLTKERDNL-KTIKEA----LEVKHDQLKEHIRETL 1376 Query: 1219 KCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLS 1278 ++ K+ + E +D E E++ F+ LL ++ + LS Sbjct: 1377 AKIQESQSKQEQSLNMKE-KDNETTKIVSEMEQFKPKDSALL--------RIEIEMLGLS 1427 Query: 1279 KIWGQQTDGMKLEFGEENLPKEETEFLSIHSQM--TNLEDIDVNHKSKLSSLQDLEKTKL 1336 K + D MK E++ + E L S N+++I H L+ E+ K+ Sbjct: 1428 KRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKH------LETEEELKV 1481 Query: 1337 EE-QVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSESTVPPSLPVDSVVITESD 1395 ++E E I+ L+ L E E EI +QK+L+A+++ L I E + Sbjct: 1482 AHCCLKEQEETINELRVNLSEK----ETEISTIQKQLEAIND-----KLQNKIQEIYEKE 1532 Query: 1396 AQRTMYPGSCVKKNIDGTIEFSGEFGVKE---ETNIVKLLEKQYQEQLEEEVAKVIVSMS 1452 Q + S V++ ++ +F K+ ++ K+LE + Q +E ++++ Sbjct: 1533 EQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIK-- 1590 Query: 1453 IAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKE 1512 ++ E+ R+ +++ +DQ+ T E V K KE Sbjct: 1591 ----EKEEMKRVQ-----------------------EALQIERDQLKENTKEIV-AKMKE 1622 Query: 1513 EFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVS 1572 S+E KE + + K C + +E F K + + I Sbjct: 1623 -----SQE-----KEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNL------ENIETE 1666 Query: 1573 SMDASRQLMLNEEQL-------EDMRQELVRQYQEHQQATELLRQAHMRQMERQRE---- 1621 ++ ++ L N E++ +D+R E Q E LR+ R +E+Q E Sbjct: 1667 NIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIV 1726 Query: 1622 --DQEQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELR 1679 ++ QE I +L +++++ N +S ++ L +ALK L +E+L Sbjct: 1727 HMHLKEHQETIDKLRGIVSEKT-----NEISNMQKDLEHSNDALKAQDLKIQEELRIAHM 1781 Query: 1680 NSSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKAN-NRLLKILLEV 1738 + Q + ++ +G V E+T K + + E+ ++ E+ KAN ++L+ + +V Sbjct: 1782 HLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKL--QEKIQELKANEHQLITLKKDV 1839 Query: 1739 VKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSY 1798 +T V E + L + K QS + S+ E + + H E++ Sbjct: 1840 NETQKKVSE------MEQLKKQIKDQS----LTLSKLEIENLNLAQKLH-----ENLEEM 1884 Query: 1799 SGSDMPRNDINMWSKVTE-EGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKL 1857 R+++ + + E +L + L + EI E + + +S + V+KL Sbjct: 1885 KSVMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQELKTARM-LSKEHKETVDKL 1943 Query: 1858 LEAISETSSQLEHAK----VTQTELMRESFRQKQEATESLKCQEEL---RERLHEESRAR 1910 E ISE + Q+ + ++ EL ++ +++ + L+ +E++ ++++E + + Sbjct: 1944 REKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLK 2003 Query: 1911 EQL-AVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQE-LEAEQQQ 1968 +Q A LS +D + K L E E+ I+ + EL R++E L+ E+ Q Sbjct: 2004 KQFEAQNLSMQSVRMDNFQLTKKLHES--LEEIRIVAKERDEL----RRIKESLKMERDQ 2057 Query: 1969 -IQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEK-------VRDDLQ 2020 I RE+++R ++ + + E++LL + ++ + E L +C K DD Sbjct: 2058 FIATLREMIARDRQNHQVKP---EKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHY 2114 Query: 2021 KQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHER 2080 + + L +D+E+++ EL L Q + +EK F Q E Sbjct: 2115 ECLNRLSLDLEKEIEFQKELSMRVKANLSLPYLQTKHIEK------LFTANQRCSME--- 2165 Query: 2081 DVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQ 2140 F + ++KL+ L V + I E Q + + ++ +K ELL+ + LQ+D Sbjct: 2166 --FHRIMKKLKYVLSYVTK---IKEEQHESINKFEMDFIDEVEKQKELLIKIQHLQQDCD 2220 Query: 2141 ERNEEIEKLEFRVR---ELEQALLVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEI 2197 + E+ L+ +E+ L F +++ + + Q+ + R + + +E Sbjct: 2221 VPSRELRDLKLNQNMDLHIEEILKDFSESEFPSIKTEFQ-----QVLSNRKEMTQFLEEW 2275 Query: 2198 TNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAI 2257 N +E+ + ++ +N+ + Q++ + E E+ + + E+ ++ Sbjct: 2276 LNTRFDIEKLKNGIQKENDRICQVNNFFNNRIIAIMNESTEFEERSATISKEWEQDLKSL 2335 Query: 2258 KESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIR 2317 KE + ++ L A Q D N VT QL T K+ E +N L Sbjct: 2336 KEKNEKLFKNYQTLKTSLASGAQVNPTTQDNKNPHVTSRATQL---TTEKIRELENSL-- 2390 Query: 2318 DLETQIECLMSDQECVKRNREEE------------IEQLNEVIEKLQQELANIGQKTSMN 2365 E + + + + +K +E E + + N+ +EK ++ + + K ++ Sbjct: 2391 -HEAKESAMHKESKIIKMQKELEVTNDIIAKLQAKVHESNKCLEKTKETIQVLQDKVALG 2449 Query: 2366 AHSLSEEADSLKHQLDVVIAEKL----ALEQQVETANEEMTFMKNVLK--ETNFKMNQLT 2419 A EE + LK +L + EK+ E+++ + + K V++ N + +Q Sbjct: 2450 AKPYKEEIEDLKMKLVKIDLEKMKNAKEFEKEISATKATVEYQKEVIRLLRENLRRSQQA 2509 Query: 2420 QE 2421 Q+ Sbjct: 2510 QD 2511 Score = 205 bits (522), Expect = 6e-52 Identities = 405/1993 (20%), Positives = 833/1993 (41%), Gaps = 283/1993 (14%) Query: 1717 LSNERYALQKANNRLLKILLEVVKTTAAV------EETIGRHVLGILDRSSKSQSSASLI 1770 L E+ LQK N ++ L ++ T++++ + R V L + +K ++S + Sbjct: 379 LLEEKDLLQKVQNEKIENLTRMLVTSSSLTLQQELKAKRKRRVTWCLGKINKMKNS-NYA 437 Query: 1771 WRSEAEASVKSCVHE---EHTRVTDESIPSYSGSDMPRNDINMWSKV---------TEEG 1818 + ++ + H+ R DES+ S SD+ N ++ S++ +E Sbjct: 438 DQFNIPTNITTKTHKLSINLLREIDESV--CSESDVFSNTLDTLSEIEWNPATKLLNQEN 495 Query: 1819 TELSQRLVRSGFAGTEID-----PENEELMLNISSR--------LQAAVEK-----LLEA 1860 E +R+ + +D E EE+ L + + L+ +K L+ Sbjct: 496 IESELNSLRADYDNLVLDYEQLRTEKEEMELKLKEKNDLDEFEALERKTKKDQEMQLIHE 555 Query: 1861 ISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHE--ESRAREQLAVELS 1918 IS + ++HA+V +L E E L+ +E+ ++L E +S+ E + ++LS Sbjct: 556 ISNLKNLVKHAEVYNQDLENEL----SSKVELLREKEDQIKKLQEYIDSQKLENIKMDLS 611 Query: 1919 KA-EGVIDGYADEKTLFERQIQEKTDIIDR------LEQELLCASNRLQELEAEQQQIQE 1971 + E + D ++TLF+ + T +D L E L +++EL +Q++ Sbjct: 612 YSLESIEDPKQMKQTLFDAE----TVALDAKRESAFLRSENLELKEKMKELATTYKQMEN 667 Query: 1972 ERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVE 2031 + +L Q EA K +E++L ++ K + KV DL +++E Sbjct: 668 DIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLID---GKVPKDL-----LCNLELE 719 Query: 2032 EQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLE 2091 +++ +L++E N E+ ++N+AL +++ + + +++ E ER ++EIQ Sbjct: 720 GKIT---DLQKELNKEV----EENEALREEVILLSEL---KSLPSEVER--LRKEIQDKS 767 Query: 2092 QQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEF 2151 ++L ++ T E ++L + + K + LL +I + +++ + Sbjct: 768 EELHII----------TSEKDKLFSEVVHKESRVQGLL-------EEIGKTKDDLATTQS 810 Query: 2152 RVRELEQALLVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREEL 2211 + +Q H E K ++ LE +R +EI NL ++ ++F L Sbjct: 811 NYKSTDQEFQNFKTLHMD-FEQKYKMVLEEN--------ERMNQEIVNLSKEAQKFDSSL 861 Query: 2212 ENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVL 2271 E+ +L+ + +E RL E+EQ K+ +E ++S + + + L Sbjct: 862 GALKTELSYKTQELQEKTREVQERLNEMEQ----LKEQLEN-----RDSTLQTVEREKTL 912 Query: 2272 FGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQE 2331 + Q E+ + Q + + +LQ+ L+I E+++L D+ + + QE Sbjct: 913 ITEKLQQTLEEVKTLTQEKDDLKQLQESLQI--------ERDQLKSDIHDTVNMNIDTQE 964 Query: 2332 CVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAH---SLSEEADSLKHQLDVVIAEKL 2388 + RN E ++Q E I L+ + I ++ S N H + E D + ++ V I +K Sbjct: 965 QL-RNALESLKQHQETINTLKSK---ISEEVSRNLHMEENTGETKDEFQQKM-VGIDKKQ 1019 Query: 2389 ALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAID 2448 LE + T N + E K+ L QE L++ ESV + + + I+ Sbjct: 1020 DLEAK-NTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIE 1078 Query: 2449 HLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELT 2508 +++ EL + L ++ K E K+ +G + RL ++E + K +L Sbjct: 1079 MTIENQEELRL-LGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQ 1137 Query: 2509 QCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEE----KVAAALVSQIQLEAVQEYAKFCQ 2564 + +Q+ ++QE E +QKKI ++ + E ++ + +LE Q+ + + Sbjct: 1138 EKQQQLLNVQE----EMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYE 1193 Query: 2565 DNQTISSEPE-RTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEI 2623 + ++I+ E + +Q + D L I + + + ++ H L +E ++ Sbjct: 1194 EVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDE 1253 Query: 2624 AEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNEL 2683 ++V EK +++ Q L + + K Q E Q E+L E+ + E NEL Sbjct: 1254 LRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQ--ELLPNVKEVSETQET---MNEL 1308 Query: 2684 EALRAESVATKAE-LASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSIL 2742 E L +S + LA + + +L E+ + + SL K+ RD+L KE L + Sbjct: 1309 ELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKE----RDNLKTIKEALEVK 1364 Query: 2743 EKEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQT--------PQILVKNA 2794 + + ++E+ + S ++ + + T KI S + +I ++ Sbjct: 1365 HDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEML 1424 Query: 2795 GIQINLQSECSSEEVTEIISQFTEKIEKMQELHAAE-------ILDMESRHISETETLKR 2847 G+ LQ S + + +++ + ++++QE+ +E I ++ ++H+ E LK Sbjct: 1425 GLSKRLQE---SHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKV 1481 Query: 2848 EHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREICSSDSGSDWGQGIYL 2907 H LKE+ T+ + L KE Q + +D + Q IY Sbjct: 1482 AHCC----LKEQEETINELRVNLSEKE-------TEISTIQKQLEAINDKLQNKIQEIYE 1530 Query: 2908 THSQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQ 2967 Q F+I +E + F + K A+ + ++L LT E+ I Sbjct: 1531 KEEQ-FNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMI 1589 Query: 2968 VSEPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFL 3027 + EE K + +D + + + A++ +S + F Sbjct: 1590 KEK---EEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQF---------------- 1630 Query: 3028 EERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQ 3087 ++TA+ T C + ++EQ + +E ++ + R Q Sbjct: 1631 -----------LKMTAVNETQEK---MCEIEHLKEQFETQKLNLENIETENIRLT----Q 1672 Query: 3088 ALHAQMNG-RKITLKRE-----QESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATE 3141 LH + R +T +R+ +E+ K ++ L+ N+++ ++ LE Q EL + E Sbjct: 1673 ILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKE 1732 Query: 3142 LQEQLSSEKMVVAELKSELAQTKLELETT---LKAQH-KHLKELEAFRLEVKDKTDEVHL 3197 QE + + +V+E +E++ + +LE + LKAQ K +EL + +K++ + + Sbjct: 1733 HQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDK 1792 Query: 3198 LNDTLASEQKKSRELQWALEKEKAKLGRSEER---DKEELEDLKFSLESQKQRNLQLNLL 3254 L ++ + K +Q LE AKL + ++ +L LK + +++ ++ L Sbjct: 1793 LRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQL 1852 Query: 3255 LEQQK-QLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERE 3313 +Q K Q L S+ +IE+ L+++ NLE + E+ +R + TL ER+ Sbjct: 1853 KKQIKDQSLTLSKLEIEN------LNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERD 1906 Query: 3314 LHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQME 3373 +L++ L+E +R +E+ E + ++ S + ++ ++ Sbjct: 1907 -------------------------QLKESLQETKARDLEIQQELKTARMLSKEHKETVD 1941 Query: 3374 KDRQ-VHRKTLQTEQ------EANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQ 3426 K R+ + KT+Q ++ E QKK+ ELQ K L R E+ K++ Sbjct: 1942 KLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKIN---- 1997 Query: 3427 RLQGIMQEFQKQELEREEKR----ESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGET 3482 ++ + ++F+ Q L + R + + L+++L E + D R K+E + Sbjct: 1998 EMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKESLKMERDQ 2057 Query: 3483 KESNYAKLIEMNGGGTGCNHELEMIRQKLQCVASKLQVLPQKASERLQFETADDEDFIWV 3542 + ++I + E ++ Q + L+ + E L+ + D+ + Sbjct: 2058 FIATLREMIARDRQNHQVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHY--- 2114 Query: 3543 QENIDEIILQLQKLTGQQGEEPSLVSPSTSCGSL----TERLLRQNAELTGHISQLTEEK 3598 E ++ + L L+K Q E V + S L E+L N + ++ ++ Sbjct: 2115 -ECLNRLSLDLEKEIEFQKELSMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKL 2173 Query: 3599 NDLRNMVMKLEEQ 3611 + + V K++E+ Sbjct: 2174 KYVLSYVTKIKEE 2186 Score = 199 bits (505), Expect = 6e-50 Identities = 473/2405 (19%), Positives = 986/2405 (40%), Gaps = 406/2405 (16%) Query: 1431 LLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNE 1490 LL+K E++E ++ S S+ Q+ + R K+ C + N+ Sbjct: 385 LLQKVQNEKIENLTRMLVTSSSLTLQQELKAKR-----------KRRVTWCLGK---INK 430 Query: 1491 MKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISE 1550 MK S F + K + L +E+ E + S SD + + T+SE Sbjct: 431 MKNSNYADQFNIPTNITTKTHKLSINLLREIDES----VCSESDVFS-----NTLDTLSE 481 Query: 1551 EMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQ 1610 ++ + +++I E++ D L+L+ EQL ++E+ + +E E Sbjct: 482 IEWNPATKLLNQENIESELNSLRADYDN-LVLDYEQLRTEKEEMELKLKEKNDLDEF--- 537 Query: 1611 AHMRQMERQ-REDQE-QLQEEIKRLNRQL--AQRSSIDNENLVSERERVLLEELEALKQL 1666 +ER+ ++DQE QL EI L + A+ + D EN +S + +L E+ + +K+L Sbjct: 538 ---EALERKTKKDQEMQLIHEISNLKNLVKHAEVYNQDLENELSSKVELLREKEDQIKKL 594 Query: 1667 SLAGREKLCCELRNSSTQTQNGNENQGEVEEQTFKEKE--LDRKPEDVPPEILSNERYAL 1724 + ++ + + E+ ++++ F + LD K E L Sbjct: 595 QEYIDSQKLENIKMDLSYSLESIEDPKQMKQTLFDAETVALDAKRESA----------FL 644 Query: 1725 QKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVH 1784 + N L + + E+ T +E I + +SQ A + + E ++S + Sbjct: 645 RSENLELKEKMKELATTYKQMENDIQLY---------QSQLEAKKKMQVDLEKELQSAFN 695 Query: 1785 E--EHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEEL 1842 E + T + D +P D+ N + + K+T+ EL++ + + E+ + Sbjct: 696 EITKLTSLIDGKVPK----DLLCN-LELEGKITDLQKELNKEVEENEALREEV------I 744 Query: 1843 MLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRER 1902 +L+ L + VE+L + I + S +L H ++ + + K+ + L Sbjct: 745 LLSELKSLPSEVERLRKEIQDKSEEL-HIITSEKDKLFSEVVHKESRVQGL--------- 794 Query: 1903 LHEESRAREQLAVELSKAEGVIDGYADEKTL---FERQIQEKTDIIDRLEQELLCASN-- 1957 L E + ++ LA S + + + KTL FE++ + + +R+ QE++ S Sbjct: 795 LEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEA 854 Query: 1958 ----------------RLQELEAEQQQIQE---ERELLSRQKEAMKAEAGPVEQQLLQET 1998 + QEL+ + +++QE E E L Q E + VE++ T Sbjct: 855 QKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLIT 914 Query: 1999 EKLMKEKLEVQCQAEKVRDDLQKQVKALEI-------DVEEQVSRFIELEQEKNTELMDL 2051 EKL + EV+ ++ +DDL++ ++L+I D+ + V+ I+ +++ L L Sbjct: 915 EKLQQTLEEVKTLTQE-KDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESL 973 Query: 2052 RQQNQALEKQLEKMRKFLDEQAIDREHE---RDVFQQEI------QKLE----QQLKVVP 2098 +Q + + K+ + + E+ +D FQQ++ Q LE Q L Sbjct: 974 KQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADV 1033 Query: 2099 RFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVREL-- 2156 + I E Q R++ L E ++ KEQL+ D++E E + + +R L Sbjct: 1034 KDNEIIEQQ-RKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGD 1092 Query: 2157 ----EQALLVEDRKHFGAVEAKPELS--------LEVQLQAERDAIDRKEKEITNLEEQL 2204 +Q ++ +++ H A++ + ELS +E +L+ + + K++++ N++E++ Sbjct: 1093 ELKKQQEIVAQEKNH--AIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEM 1150 Query: 2205 EQFRE---ELEN-----KNEEVQQLHMQ---LEIQKK--ESTTRLQELEQENKLFKD--- 2248 + ++ E+EN KN+E+ HM+ LE+ +K E+ ++ + +E K+ K+ Sbjct: 1151 SEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQK 1210 Query: 2249 --------------DMEKLGLAIKES---------DAMSTQDQ--HVLFGKFAQIIQEKE 2283 ++E GL KE + T D+ + K AQII ++ Sbjct: 1211 SFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQD 1270 Query: 2284 VEID--QLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEI 2341 +E +L E++ L ++ ++ + K + E E + +LE E + E E Sbjct: 1271 LEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMER 1330 Query: 2342 EQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEM 2401 +LNE ++ Q+E+ ++ ++ N ++ E + QL I E LA Q+ ++ E+ Sbjct: 1331 LRLNEKFQESQEEIKSLTKERD-NLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQS 1389 Query: 2402 TFMKNVLKETNFKMNQLTQ-------------ELFSL-KRERESVEKIQSIPENSVNVAI 2447 MK ET ++++ Q E+ L KR +ES ++++S+ + ++ Sbjct: 1390 LNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQR 1449 Query: 2448 --DHLSKDKPELEVVLTEDALKSLENQTYFK-------SFEENGKGSIINL---ETRLLQ 2495 + L + +L+ + E K LE + K EE +NL ET + Sbjct: 1450 LQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEIST 1509 Query: 2496 LESTVSAKDLELTQCYKQIKDMQEQGQF-ETEMLQKKIVNLQKIVEEKVAAALVSQIQLE 2554 ++ + A + +L ++I + +EQ + +Q+K+ L++ E + A Q Sbjct: 1510 IQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIES 1569 Query: 2555 AVQEYAKFCQDNQT-----ISSEPERTNIQNLNQLREDELGSDISALTLRISELE----- 2604 + E Q++Q I + E +Q Q+ D+L + + ++ E + Sbjct: 1570 KMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQ 1629 Query: 2605 -------SQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRS 2657 ++ E + KEQ E + N+ E + + L ++L N ++ R K+R Sbjct: 1630 FLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKERD 1689 Query: 2658 P--QDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKE 2715 E LK + N +LE + E L ++E +KL+ + K Sbjct: 1690 DLRSVEETLKVERDQLKENLRETITRDLEK-QEELKIVHMHLKEHQETIDKLRGIVSEKT 1748 Query: 2716 TNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLSKSIASQTD 2775 ++++QKDL D L K L+ ++E + E + KL ++ +TD Sbjct: 1749 NEISNMQKDLEHSNDAL-----KAQDLKIQEELRIAHMHLKEQQETID-KLRGIVSEKTD 1802 Query: 2776 GTLKISSSNQTPQILVKNAGIQINLQSECSSEE----VTEIISQFTEKIEKMQELHAAEI 2831 SN + NA +Q +Q ++E + + +++ +K+ +M++L +I Sbjct: 1803 -----KLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKK-QI 1856 Query: 2832 LDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTRE 2891 D +S +S+ E E+ Q L E +K+V+ KE ++ + + + + Sbjct: 1857 KD-QSLTLSKLEI---ENLNLAQKLHENLEEMKSVM-----KERDNLRRVEETLKLERDQ 1907 Query: 2892 ICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLS 2951 + S L ++ D+ + + + + + + L + + +Q+ Sbjct: 1908 LKES-----------LQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISD 1956 Query: 2952 LTES--PYSDGEDHSIQQVSEPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHE 3009 + + D IQ++ + L+ + + S K + QL+++ E + S Sbjct: 1957 IQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSV 2016 Query: 3010 SFSDWRGELLLALQQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQA 3069 ++ +L L + E R ++A R EL +RI+E Sbjct: 2017 RMDNF--QLTKKLHESLEEIR--IVAKERDEL----------------RRIKES------ 2050 Query: 3070 AMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQ 3129 K +R ++ ++ + A+ + + +K E+ Q+ L ++++K S++ E+ Sbjct: 2051 -----LKMERDQFIATLREMIAR-DRQNHQVKPEKRLLSDGQQHLTESLREKCSRIKELL 2104 Query: 3130 VELSSMKDR-------ATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELE 3182 S M D + +L++++ +K + +K+ L+ L Q KH+++L Sbjct: 2105 KRYSEMDDHYECLNRLSLDLEKEIEFQKELSMRVKANLSLPYL--------QTKHIEKL- 2155 Query: 3183 AFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDL-KFSL 3241 + Q+ S E ++K K L + +E+ E + KF + Sbjct: 2156 -------------------FTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKFEM 2196 Query: 3242 ESQKQRNLQLNLLLEQQKQLLNESQQKIES----QRMLYDAQLSEEQGRNLE--LQVLLE 3295 + + +E+QK+LL + Q + R L D +L++ ++E L+ E Sbjct: 2197 DFIDE--------VEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIEEILKDFSE 2248 Query: 3296 SEKVRIR-EMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEK------- 3347 SE I+ E L +E+ L+ T E L +QK+ + Sbjct: 2249 SEFPSIKTEFQQVLSNRKEMTQFLEEWLNTR-----FDIEKLKNGIQKENDRICQVNNFF 2303 Query: 3348 HSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDL 3407 ++RI+ ++NE+ +++ S ++ E+D L++ +E N + K L++ + Sbjct: 2304 NNRIIAIMNESTEFEERSATISKEWEQD-------LKSLKEKNEKLFKNYQTLKTSLAS- 2355 Query: 3408 QRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELEREEKRES-----RRILYQNLNEPTTW 3462 Q+ Q + + Q ++ ++ E E +ES +I+ T Sbjct: 2356 GAQVNPTTQDNKNPHVTSRATQLTTEKIRELENSLHEAKESAMHKESKIIKMQKELEVTN 2415 Query: 3463 SLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMIRQKLQCVASKLQVLP 3522 + + K +TKE+ ++ G E+E ++ KL K+ + Sbjct: 2416 DIIAKLQAKVHESNKCLEKTKETIQVLQDKVALGAKPYKEEIEDLKMKL----VKIDLEK 2471 Query: 3523 QKASERLQFETADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSPST---------SC 3573 K ++ + E + + + Q+ + ++ + + QQ ++ S++S T +C Sbjct: 2472 MKNAKEFEKEISATKATVEYQKEVIRLLRENLR-RSQQAQDTSVISEHTDPQPSNKPLTC 2530 Query: 3574 G---------------SLTERLLRQNAELTGHISQLTEEKNDLRNMVMKLEEQIRWYRQT 3618 G S RL ++ ++L QL ++KN+L + L +++ +++ Sbjct: 2531 GGGSGIVQNTKALILKSEHIRLEKEISKLKQQNEQLIKQKNELLSNNQHLSNEVKTWKER 2590 Query: 3619 GAGRD 3623 R+ Sbjct: 2591 TLKRE 2595 Score = 197 bits (501), Expect = 2e-49 Identities = 497/2511 (19%), Positives = 1031/2511 (41%), Gaps = 392/2511 (15%) Query: 1052 DKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRL 1111 ++VS + + K+ + L V+ E+ +A + + +L +E ++L+ QN+ Sbjct: 336 NEVSTDEALLKRYRKEIMDLKKQLEEVSLETRAQAMEKDQLAQLLEEKDLLQKVQNE--- 392 Query: 1112 QMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQT 1171 + + + LV S+ + +E K + L KI +++ + + Sbjct: 393 --KIENLTRMLVTSSSLTLQQELKAKRKRRVTWCLG---------KINKMKNSNYADQFN 441 Query: 1172 MKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSG 1231 + T T K L+ ++ ++V E F TL ++ + PA K +N Sbjct: 442 IPTNITTKTHKLSINLLREIDESVCSESDVFSNTLDTLSEIEWNPATKL-LN-------- 492 Query: 1232 DYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLE 1291 QEN+ + LN + +Y+ L++ +L + + M+L+ Sbjct: 493 ---------------------QENIESELNSLRADYDNLVLDYEQLRT----EKEEMELK 527 Query: 1292 FGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQ 1351 E+N + EF ++ + +++ + H+ +S+L++L K E Q+LE+ +SS Sbjct: 528 LKEKN---DLDEFEALERKTKKDQEMQLIHE--ISNLKNLVK-HAEVYNQDLENELSSKV 581 Query: 1352 QQLKETEQNYEAEIHCLQKRLQAVSESTVPPSLPVDSVVITES-----DAQRTMYPGSCV 1406 + L+E E K+LQ +S ++ +D ES ++T++ V Sbjct: 582 ELLREKEDQI--------KKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQTLFDAETV 633 Query: 1407 KKNIDGTIEF--SGEFGVKEETNIVKLLEKQ-------YQEQLEEEVAKVI---VSMSIA 1454 + F S +KE+ + KQ YQ QLE + + + A Sbjct: 634 ALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSA 693 Query: 1455 FAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEF 1514 F + T+L+ + GK K + E + K ++ +V E Sbjct: 694 FNEITKLTSLIDGKV----PKDLLCNLELEGKITDLQKELNKEVEENEALREEVILLSEL 749 Query: 1515 KPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSM 1574 K L E+ KEI + + H I KD + + E+ K+ Q + +EI + Sbjct: 750 KSLPSEVERLRKEIQDKSEELHIITSEKDKLFS---EVVHKESRV---QGLLEEIGKTKD 803 Query: 1575 DASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLN 1634 D + N + + Q + + +Q +++ + + ER ++ L +E ++ + Sbjct: 804 DLATT-QSNYKSTDQEFQNFKTLHMDFEQKYKMV----LEENERMNQEIVNLSKEAQKFD 858 Query: 1635 RQL-AQRSSIDNENL-VSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNENQ 1692 L A ++ + + + E+ R + E L ++QL +E+L E R+S+ QT Sbjct: 859 SSLGALKTELSYKTQELQEKTREVQERLNEMEQL----KEQL--ENRDSTLQTVE----- 907 Query: 1693 GEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRH 1752 E+T ++L + E+V + L+ E+ L++ L +E + + + +T+ Sbjct: 908 ---REKTLITEKLQQTLEEV--KTLTQEKDDLKQLQESLQ---IERDQLKSDIHDTVN-- 957 Query: 1753 VLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWS 1812 + I + + SL E ++KS + EE +R +++M Sbjct: 958 -MNIDTQEQLRNALESLKQHQETINTLKSKISEEVSR-----------------NLHMEE 999 Query: 1813 KVTEEGTELSQRLVRSGFAGTEIDPENEELML-----NISSRLQAAVEKLLEAISETSSQ 1867 E E Q++V +++ +N + + N Q + L++ +E Sbjct: 1000 NTGETKDEFQQKMVGID-KKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQM 1058 Query: 1868 LEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELS---KAEGVI 1924 LE + + E ++ ++ E T ++ QEELR E + +E +A E + K EG + Sbjct: 1059 LESV-IAEKEQLKTDLKENIEMT--IENQEELRLLGDELKKQQEIVAQEKNHAIKKEGEL 1115 Query: 1925 DGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQK---E 1981 D E +++EK+ + +Q+LL + E++ + +I+ + L ++ E Sbjct: 1116 SRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLE 1175 Query: 1982 AMKAEAGPVEQQL---LQETEKLMKEKL---EVQCQAEKVRDDLQ---KQVKALEIDVEE 2032 M+ E + Q+L +E + + KE+ E+Q E RD L+ ++++A + +E Sbjct: 1176 HMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKE 1235 Query: 2033 QVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQ 2092 ++ + + +++ E +D +++ + EK + ++ Q +++ H + Q+EI L + Sbjct: 1236 EL-KIAHIHLKEHQETIDELRRSVS-----EKTAQIINTQDLEKSHTK--LQEEIPVLHE 1287 Query: 2093 QLKVVPRFQPISEHQT--REVEQLANHLKEK-TDKCSELLLSKEQLQRDIQERNEEIEKL 2149 + +++P + +SE Q E+E L K + + + + + +L QE EEI+ L Sbjct: 1288 EQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSL 1347 Query: 2150 ---EFRVRELEQALLVED---RKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQ 2203 ++ +++AL V+ ++H AK + S Q Q+ + K+ E T + + Sbjct: 1348 TKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLN--MKEKDNETTKIVSE 1405 Query: 2204 LEQFRE----------ELENKNEEVQQLHMQLE--IQKKESTTRLQE-LEQENKLFKDDM 2250 +EQF+ E+ ++ +Q+ H +++ ++K+ RLQE L+ E+ K+++ Sbjct: 1406 MEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENI 1465 Query: 2251 EKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTD---NK 2307 +++ E++ + H + + I E V + + +++ +Q+QL+ D NK Sbjct: 1466 KEIVAKHLETEE-ELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNK 1524 Query: 2308 VIE--EKNELIRDLE-TQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSM 2364 + E EK E + ++++ +++ + K +R+ + L + K+ EL N Q++ Sbjct: 1525 IQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKML-ELTNRLQESQE 1583 Query: 2365 NAHSLSEEADSLKHQLDVVIAEKLALEQQV--------ETANEEMTFMK-NVLKETNFKM 2415 + +E + +K + + E+ L++ E+ +E F+K + ET KM Sbjct: 1584 EIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKM 1643 Query: 2416 NQL--------TQELFSLKRERESVEKIQSIPEN-----SVNVAIDHLSKDKPELEVVLT 2462 ++ TQ+L E E++ Q + EN SV D L + L+V Sbjct: 1644 CEIEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKV--E 1701 Query: 2463 EDALKSLENQTYFKSFEENGKGSIINLETRLLQ-----LESTVSAKDLELTQCYKQIKDM 2517 D LK +T + E+ + I+++ + Q L VS K E++ K ++ Sbjct: 1702 RDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHS 1761 Query: 2518 QEQGQFETEMLQKKI-VNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERT 2576 + + + +Q+++ + + E++ + I E + + +D + +++ + Sbjct: 1762 NDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQE- 1820 Query: 2577 NIQNL--NQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKK 2634 IQ L N+ + L D++ ++SE+E Q+ + L ++EI N+ +K + Sbjct: 1821 KIQELKANEHQLITLKKDVNETQKKVSEME-QLKKQIKDQSLTLSKLEIENLNLAQKLHE 1879 Query: 2635 LLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATK 2694 LE E K KE+ + E LK + + + +LE ++ E + Sbjct: 1880 NLE--------EMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDLE-IQQELKTAR 1930 Query: 2695 AELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESK 2754 +KE +KL+E++ K ++ +QKDL + +D L + ++QE + Sbjct: 1931 MLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDEL--------------QKKIQELQ 1976 Query: 2755 KACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTEIIS 2814 K K + + + D + N+ Q+ + +++QS V Sbjct: 1977 K---------KELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQS------VRMDNF 2021 Query: 2815 QFTEKI-EKMQELHAAEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRSK 2873 Q T+K+ E ++E+ E R I E+ ++R+ ++A TL+ +I R Sbjct: 2022 QLTKKLHESLEEIRIVAKERDELRRIKESLKMERDQFIA---------TLREMIARDRQN 2072 Query: 2874 EGSSIPELAHSDAYQ-----TREICSSDSG-----SDWGQGIYLTHSQGFDIASEGRGEE 2923 + SD Q RE CS S+ + D+ E ++ Sbjct: 2073 HQVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKEIEFQK 2132 Query: 2924 SES----ATDSFP----KKIKGLLRAVHNEGMQ----------VLSLTESPYSDGEDHSI 2965 S A S P K I+ L A M+ VLS + + + SI Sbjct: 2133 ELSMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYV-TKIKEEQHESI 2191 Query: 2966 QQVSEPWLEERKAYINTISSLKDLITKMQ-LQREAEVYDSSQSHESFSDWRGELLLALQQ 3024 + +++E + K+L+ K+Q LQ++ +V + + L +++ Sbjct: 2192 NKFEMDFIDE-------VEKQKELLIKIQHLQQDCDVPSRELRDLKLNQ---NMDLHIEE 2241 Query: 3025 VFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQ--------EQGVEYQAAMECLQK 3076 + + + +TE + ++ + LE+ + + G++ + C Sbjct: 2242 ILKDFSESEFPSIKTEFQQV-LSNRKEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQVN 2300 Query: 3077 ADRRSLLSEIQALHAQMNGRKITLKREQESE----KPSQELLEYNIQQKQSQMLE-MQVE 3131 + + I + R T+ +E E + K E L N Q ++ + QV Sbjct: 2301 NFFNNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQVN 2360 Query: 3132 LSSMKDR---ATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEV 3188 ++ ++ T QL++EK + EL++ L + K A HK K ++ + Sbjct: 2361 PTTQDNKNPHVTSRATQLTTEK--IRELENSLHEAKES------AMHKESKIIKMQK--- 2409 Query: 3189 KDKTDEVHLLNDTLASEQKKSRELQWALEKEKA-------KLGRSEERDKEELEDLKFSL 3241 E+ + ND +A Q K E LEK K K+ + KEE+EDLK L Sbjct: 2410 -----ELEVTNDIIAKLQAKVHESNKCLEKTKETIQVLQDKVALGAKPYKEEIEDLKMKL 2464 Query: 3242 ---ESQKQRNLQ--------LNLLLEQQKQLLNESQQKIESQRMLYDAQLSEE----QGR 3286 + +K +N + +E QK+++ ++ + + D + E Q Sbjct: 2465 VKIDLEKMKNAKEFEKEISATKATVEYQKEVIRLLRENLRRSQQAQDTSVISEHTDPQPS 2524 Query: 3287 NLEL-------------QVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPS 3333 N L ++L+SE +R+ + S L ++ E QL S S Sbjct: 2525 NKPLTCGGGSGIVQNTKALILKSEHIRLEKEISKLKQQNE---QLIKQKNELLSNNQHLS 2581 Query: 3334 EDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQ 3384 ++ ++ L+ + + V N + K+ ++++ Q + LQ Sbjct: 2582 NEVKTWKERTLKREAHKQVTCENSPKSPKVTGTASKKKQITPSQCKERNLQ 2632 Score = 170 bits (430), Expect = 3e-41 Identities = 250/1236 (20%), Positives = 559/1236 (45%), Gaps = 184/1236 (14%) Query: 4 EERQKKLEAGKAKLAQFRQRKAQSDGQSPSKKQKKKRKTS-SSKHDVSAHHDLNIDQSQC 62 +E Q+K + +L + Q K Q + + + + ++ KT + K + + Q + Sbjct: 873 QELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKD 932 Query: 63 NEMYINSSQRVESTVIPESTIMRTLHSGEITSHEQGFSVEL----ESEISTTADDCSSEV 118 + + S ++E + +S I T++ T + ++E + I+T S EV Sbjct: 933 DLKQLQESLQIERDQL-KSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEV 991 Query: 119 N-GCSFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHEIEELNRE 177 + TG+ + +++ G+D + ++ ++E+ +Q +I L +E Sbjct: 992 SRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQE 1051 Query: 178 LEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQK 237 E++ Q E+ I +++ + T L N++ ++E L L K Sbjct: 1052 KNELQ-----------QMLESVIAEKEQLKTDLKENIEMTIENQEE-----LRLLGDELK 1095 Query: 238 LQIQFQQLQASETLRNSTHSSTAAD-LLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTM 296 Q + + + ++ S D L + ++++ QQL+E+ L + Q+ Sbjct: 1096 KQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQE------- 1148 Query: 297 QISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTAD 356 ++S +Q+KI ++EN K E++ KE +E + T+ + Sbjct: 1149 EMSEMQKKI--------NEIENL-KNELKNKELTLEHMETERL----------------- 1182 Query: 357 KLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFET 416 EL +++ + +E+K++ E K+ ++ E L G + E++ + + E Sbjct: 1183 ----ELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKE-EL 1237 Query: 417 DIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHK-------- 468 I +E Q +++LR + E Q I Q+L + H EE+ H+ Sbjct: 1238 KIAHIHLKEHQETIDELRRSVSEKTAQII--NTQDLEKSHTKLQEEIPVLHEEQELLPNV 1295 Query: 469 ------GEMENALRSYSNITVNEDQIKLMNVAIN--ELNIKLQDTNSQKEKLKEELGLIL 520 E N L + + +D L + + LN K Q++ + + L +E + Sbjct: 1296 KEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLK 1355 Query: 521 EEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASE 580 K AL+ + + L E + RE + + +++ ++QE LN K T +IVS E Sbjct: 1356 TIKEALEVKHDQLKEHI---RETLAKIQESQSKQEQSLNMKEKDNET-----TKIVSEME 1407 Query: 581 SRKELE---LKHEAEVTNYKIKLEMLEKEKNAV------LDRMAESQEAELERLR---TQ 628 K + L+ E E+ +L+ E +V L R+ E ++E ++L+ + Sbjct: 1408 QFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKE 1467 Query: 629 LLFSH---EEELS------KLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIE 679 ++ H EEEL K +E+ E R+N+ + + + ++Q++ + +++ KI+ Sbjct: 1468 IVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEIST-IQKQLEAINDKLQNKIQ 1526 Query: 680 TMQFEKDNLITKQ--------NQL--ILEISKLKDLQQSLVNSKSEEMTLQINELQKEIE 729 + +++ KQ N+L E K KD + SK E+T ++ E Q+EI+ Sbjct: 1527 EIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQ 1586 Query: 730 ILRQEEKEKGTLEQ--EVQELQLKTELLEKQMKEKENDLQE-KFAQLEAENSILKDEKKT 786 I+ +E++E +++ +++ QLK E K KE+ +E +F ++ A N +T Sbjct: 1587 IMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVN-------ET 1639 Query: 787 LEDMLKI-HTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEK 845 E M +I H E + + L++I++++ + +IL E E+++ + K Sbjct: 1640 QEKMCEIEHLKEQFETQKLNLENIETEN-----IRLTQILHENLEEMR--------SVTK 1686 Query: 846 QRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRI 905 +R+ E+ +V +L K++L ++ + +LE + +LK ++ +HL+ Sbjct: 1687 ERDDLRSVEETLKVERDQL----------KENLRETITR-DLEKQEELKIVH--MHLKEH 1733 Query: 906 NPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELS-QRLSDLSE 964 T K++ V ++ E M + +E + + ++ ++ +E+L ++ L + E Sbjct: 1734 QETIDKLRGIVSEKTN----EISNMQKDLE-HSNDALKAQDLKIQEELRIAHMHLKEQQE 1788 Query: 965 QLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVV 1024 + + G +S +++ +++++ E + + +E + + +++ + Q+ +L V Sbjct: 1789 TIDKLRGIVSEKTDKLSNMQKDLENSNAKLQE--------KIQELKANEHQLITLKKDVN 1840 Query: 1025 TMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKE-SS 1083 + +E + ++ K ++S + K+ EN+ + ++ + L+ + SV KE + Sbjct: 1841 ETQKKVSE--MEQLKKQIKDQS--LTLSKLEIENLNLAQKLHEN---LEEMKSVMKERDN 1893 Query: 1084 LRATQPS---ENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKD 1140 LR + + E D+L++ L K+ +++ +++ R+ LS + VD++RE + +EK Sbjct: 1894 LRRVEETLKLERDQLKESLQETKARDLEIQQELKTARM-LSKEHKETVDKLREKI-SEKT 1951 Query: 1141 KALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQE 1176 + ++++L +++E K++Q++ + ELQ ++ +E Sbjct: 1952 IQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKE 1987 Score = 151 bits (382), Expect = 1e-35 Identities = 376/1864 (20%), Positives = 766/1864 (41%), Gaps = 271/1864 (14%) Query: 1930 EKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGP 1989 + T + ++ ++ R +E++ +L+E+ E + E++ L++ E Sbjct: 330 KNTPYVNEVSTDEALLKRYRKEIMDLKKQLEEVSLETRAQAMEKDQLAQLLE-------- 381 Query: 1990 VEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFI-ELEQEKNTEL 2048 E+ LLQ K+ EK+E + L Q + L+ + +V+ + ++ + KN+ Sbjct: 382 -EKDLLQ---KVQNEKIENLTRMLVTSSSLTLQ-QELKAKRKRRVTWCLGKINKMKNSNY 436 Query: 2049 MDLRQQNQALEKQLEKMR----KFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPIS 2104 D + + K+ + +DE E DVF + L + + P + Sbjct: 437 ADQFNIPTNITTKTHKLSINLLREIDESVCS---ESDVFSNTLDTLSEI-----EWNPAT 488 Query: 2105 EHQTRE-VEQLANHLKEKTDKC----SELLLSKEQLQRDIQERNE--EIEKLEFRVRELE 2157 + +E +E N L+ D +L KE+++ ++E+N+ E E LE + ++ + Sbjct: 489 KLLNQENIESELNSLRADYDNLVLDYEQLRTEKEEMELKLKEKNDLDEFEALERKTKKDQ 548 Query: 2158 QALLVEDRKHFGAVEAKPEL---SLEVQLQAERDAIDRKEKEITNLEE-----QLEQFRE 2209 + L+ + + + E+ LE +L ++ + + KE +I L+E +LE + Sbjct: 549 EMQLIHEISNLKNLVKHAEVYNQDLENELSSKVELLREKEDQIKKLQEYIDSQKLENIKM 608 Query: 2210 ELENKNEEVQQLHMQLEIQKKESTTRLQE------LEQENKLFKDDMEKLGLAIK--ESD 2261 +L E ++ + T L L EN K+ M++L K E+D Sbjct: 609 DLSYSLESIEDPKQMKQTLFDAETVALDAKRESAFLRSENLELKEKMKELATTYKQMEND 668 Query: 2262 AMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQL--KITTDNKVIEEKNELIRDL 2319 Q Q + K Q+ EKE++ NE +TKL + K+ D E I DL Sbjct: 669 IQLYQSQ-LEAKKKMQVDLEKELQ-SAFNE-ITKLTSLIDGKVPKDLLCNLELEGKITDL 725 Query: 2320 ETQIECLMSDQECVKRNREE-----EIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEAD 2374 + ++ + + E + REE E++ L +E+L++E+ Q S H ++ E D Sbjct: 726 QKELNKEVEENEAL---REEVILLSELKSLPSEVERLRKEI----QDKSEELHIITSEKD 778 Query: 2375 SLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEK 2434 L +E + E +V+ EE+ K+ L T QE + K E+ Sbjct: 779 KL-------FSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQ 831 Query: 2435 IQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLL 2494 + ++VL E+ + E K ++ ++ L Sbjct: 832 ---------------------KYKMVLEENERMNQEIVNLSKEAQK--------FDSSLG 862 Query: 2495 QLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLE 2554 L++ +S K EL + +++++ + + E L+ + LQ + EK L+++ + Sbjct: 863 ALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKT---LITEKLQQ 919 Query: 2555 AVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSL 2614 ++E Q+ + +Q Q+ D+L SDI + + Q+ SL Sbjct: 920 TLEEVKTLTQEKDDLKQ------LQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESL 973 Query: 2615 ILEKEQVEIAEKNVLEKEKKLLELQKLL-EGNEKKQREKEKKRSPQDVEVLKTTTELFHS 2673 +E + + + E+ + L +++ E ++ Q++ QD+E T T Sbjct: 974 KQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADV 1033 Query: 2674 NEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLA 2733 + E + + ++ S ++ +LQ+ L L+ DL + + Sbjct: 1034 KDN------------EIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTI 1081 Query: 2734 EAKEKLSIL----EKEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQI 2789 E +E+L +L +K+ E QE A E +LS++ + K+ +Q Q+ Sbjct: 1082 ENQEELRLLGDELKKQQEIVAQEKNHAIKKEG---ELSRTCDRLAEVEEKLKEKSQ--QL 1136 Query: 2790 LVKNAGIQINLQSECSSEEVTEIISQFTEKIEKMQELHAAEILDMESRHISETETLKREH 2849 K + +N+Q E +S+ +KI +++ L +++++ ++ E ++ E Sbjct: 1137 QEKQQQL-LNVQEE---------MSEMQKKINEIENLKN----ELKNKELT-LEHMETER 1181 Query: 2850 YVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREICSSDSGSDWGQGIYLTH 2909 Q L E +K++ +KE + EL S ++T D +G Y+ Sbjct: 1182 LELAQKLNENYEEVKSI-----TKERKVLKELQKS--FETER--------DHLRG-YIRE 1225 Query: 2910 SQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVS 2969 + + ++ + + + I L R+V + Q+++ + S H+ Q Sbjct: 1226 IEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKS----HTKLQEE 1281 Query: 2970 EPWLEERKAYINTISSLKDLITKMQLQREAEVY-DSSQSHESFSDWRGEL-LLALQQVFL 3027 P L E + + ++K++ + E E+ + S + +S + R E+ L L + F Sbjct: 1282 IPVLHEEQ---ELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQ 1338 Query: 3028 EERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQ 3087 E + + + + +A L +++E E A ++ Q +SL + Sbjct: 1339 ESQEEIKSLTKERDNLKTIKEA---LEVKHDQLKEHIRETLAKIQESQSKQEQSLNMK-- 1393 Query: 3088 ALHAQMNGRKITLKREQESEKPSQEL-LEYNIQQKQSQMLEMQVELSSM---KDRATELQ 3143 KI + EQ K S L +E + ++ E E+ S+ KD LQ Sbjct: 1394 --EKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQ 1451 Query: 3144 EQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELE----AFRLEVKDKTDEVHLLN 3199 E L SE + E E+ LE E LK H LKE E R+ + +K E+ + Sbjct: 1452 EVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQ 1511 Query: 3200 DTL-ASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQ 3258 L A K ++Q EKE+ + +E++ +LK E +K ++ L Sbjct: 1512 KQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSAL------- 1564 Query: 3259 KQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQL 3318 Q IES+ + +L E Q E+Q++++ EK ++ + L ER+ QL Sbjct: 1565 --------QSIESKMLELTNRLQESQE---EIQIMIK-EKEEMKRVQEALQIERD---QL 1609 Query: 3319 QSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRI-VELLNETEKYKLDSLQTRQQMEKDRQ 3377 + + +++++ ++++ E+++ + + +NET++ + ++Q E ++ Sbjct: 1610 KEN-----------TKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFE-TQK 1657 Query: 3378 VHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQK 3437 ++ + ++TE N + +HE ++ + ++ ++ R L +E +L+ ++E Sbjct: 1658 LNLENIETE---NIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETIT 1714 Query: 3438 QELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQ-----KIEGETKESNYAKLIE 3492 ++L EK+E +I++ +L E T D+ R V ++ ++ + + SN A Sbjct: 1715 RDL---EKQEELKIVHMHLKEHQE---TIDKLRGIVSEKTNEISNMQKDLEHSNDA---- 1764 Query: 3493 MNGGGTGCNHELEMIRQKL---QCVASKLQVLPQKASERLQFETADDEDF-IWVQENIDE 3548 + EL + L Q KL+ + + +++L D E+ +QE I E Sbjct: 1765 LKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQE 1824 Query: 3549 IILQLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKL 3608 + +L + + V+ + S E+L +Q + + +S+L E N+ KL Sbjct: 1825 LKANEHQLITLKKD----VNETQKKVSEMEQLKKQIKDQSLTLSKLEIEN---LNLAQKL 1877 Query: 3609 EEQIRWYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRAEAEVYKL 3668 E + + RDN R +E E+ L++SL+ +A ++ Sbjct: 1878 HENLEEMKSVMKERDNLRRV---------------EETLKLERDQLKESLQETKARDLEI 1922 Query: 3669 KAELRNDSLLQTLSPDSEHVTLKRIYGKYLRAESFRKALIYQKKYLLLLLGGFQECEDAT 3728 + EL+ +L ++ ++I K ++ +K L K L + QE + Sbjct: 1923 QQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKI---QELQKKE 1979 Query: 3729 LALL 3732 L LL Sbjct: 1980 LQLL 1983 >gi|109255234 centrosomal protein 290kDa [Homo sapiens] Length = 2479 Score = 233 bits (593), Expect = 4e-60 Identities = 491/2484 (19%), Positives = 1011/2484 (40%), Gaps = 439/2484 (17%) Query: 160 MESELAGKQHEIEELNRELEE--------------------------MRVTYGTEGL--- 190 +E +L K E+E++ +ELE+ R+ E L Sbjct: 120 LEKQLEQKDRELEDMEKELEKEKKVNEQLALRNEEAENENSKLRRENKRLKKKNEQLCQD 179 Query: 191 -----QQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQIQFQQL 245 +Q+ + + R G + + L + E + + E LTE ++K+++Q Q++ Sbjct: 180 IIDYQKQIDSQKETLLSRRGEDSDYRSQLSKKNYELIQYLDEIQTLTEANEKIEVQNQEM 239 Query: 246 QASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKI 305 + + L S + + + HQ D++++ +K+ + + +Q+ L + + Sbjct: 240 R--KNLEESVQEMEKMTDEYNRMKAIVHQ-----TDNVIDQLKKENDHYQLQVQELTDLL 292 Query: 306 KVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTT----ADKL-LG 360 K + E+D + + +++E + I+ + +IIE ++ L++KL ADK + Sbjct: 293 K-SKNEEDDPIMVAVNAKVEEWKLILSSKDDEIIEYQQMLHNLREKLKNAQLDADKSNVM 351 Query: 361 ELQEQIVQKNQEIKNMKLEL---TNSKQKERQSSEEIK---QLMGTVEELQKRNHKDSQF 414 LQ+ I +++ +IK + ++ T +K E++K Q L ++ H Q Sbjct: 352 ALQQGIQERDSQIKMLTEQVEQYTKEMEKNTCIIEDLKNELQRNKGASTLSQQTHMKIQS 411 Query: 415 ETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENA 474 DI++ +E +R E A+ E K + + + + ++++ ++ G +E+A Sbjct: 412 TLDILKEKTKEAERTAELAEADARE---------KDKELVEALKRLKDYESGVYG-LEDA 461 Query: 475 LRSYSN----ITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGL----------IL 520 + N I + + +I+++ IN+L +K+ D + E L+E +GL Sbjct: 462 VVEIKNCKNQIKIRDREIEILTKEINKLELKISDFLDENEALRERVGLEPKTMIDLTEFR 521 Query: 521 EEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASE 580 K Q+Q + L E ++ R + ++ ++ + S L E ++ +E Sbjct: 522 NSKHLKQQQYRAENQILLKEIESLEEERLDLKKKIRQMAQERGKRSATSGLTTEDLNLTE 581 Query: 581 SRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKL 640 + + + E ++ +K + KN L R +E +LER RT ++ + +L +L Sbjct: 582 NISQGDRISERKLDLLSLKNMSEAQSKNEFLSRELIEKERDLERSRT-VIAKFQNKLKEL 640 Query: 641 KEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEIS 700 E+ +Q++ E+ Q I+ MQ + D K + L I Sbjct: 641 VEE--------------------NKQLEEGMKEILQAIKEMQKDPD---VKGGETSLIIP 677 Query: 701 KLKDLQQSLVNSKSE-------EMTLQINELQKEIEILRQE----EKEKGTLEQEVQELQ 749 L+ L ++ + +E + Q+++L E LRQE KE Q++ + Sbjct: 678 SLERLVNAIESKNAEGIFDASLHLKAQVDQLTGRNEELRQELRESRKEAINYSQQLAKAN 737 Query: 750 LKTELLEKQ---MKEKEN--------DLQEKFA-------------------QLEAENSI 779 LK + LEK+ +++ E DL + A +LE + Sbjct: 738 LKIDHLEKETSLLRQSEGSNVVFKGIDLPDGIAPSSASIINSQNEYLIHLLQELENKEKK 797 Query: 780 LKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQL 839 LK+ + +LED + + ++ L++ + + K W+ E + + EE L+ Q Q Sbjct: 798 LKNLEDSLEDYNRKFAVIRHQQSLLYKEYLSEK---ETWKTESKTIKEEKRKLEDQVQQD 854 Query: 840 NEEIEKQRNTFSFAEKN-----------------FEVNYQELQEEYACLLKVKDDLEDSK 882 ++++ N + + + +VN + L +Y L++++ L Sbjct: 855 AIKVKEYNNLLNALQMDSDEMKKILAENSRKITVLQVNEKSLIRQYTTLVELERQLRKEN 914 Query: 883 NKQELEYKSKLKALNEELH-LQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTEL 941 KQ+ E S + E++ LQR F E F L+ +VV D + Sbjct: 915 EKQKNELLSMEAEVCEKIGCLQR------------FKEMAIFKIAALQ--KVV--DNSVS 958 Query: 942 MEKLEVTKREKLELSQRLSDLSEQ---LKQKHGEISFLNEEVKSLKQEKEQVSLRCRELE 998 + +LE+ ++ EL+ + D+ ++ L Q+ + L E SLK++ E ++ +ELE Sbjct: 959 LSELELANKQYNELTAKYRDILQKDNMLVQRTSNLEHLECENISLKEQVESIN---KELE 1015 Query: 999 IIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVS-FE 1057 I + ++ Q + L G E S+ K KS + + K++ E Sbjct: 1016 --ITKEKLHTIEQAWEQETKL----------GNESSMDKAKKSITNSDIVSISKKITMLE 1063 Query: 1058 NMTVGEESKQE--QLILDHLPSVTKESSLR----ATQPSENDK-----------LQKEL- 1099 + E + E Q + +HL + K+ R T+ +E K L+ EL Sbjct: 1064 MKELNERQRAEHCQKMYEHLRTSLKQMEERNFELETKFAELTKINLDAQKVEQMLRDELA 1123 Query: 1100 -------------NVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSL 1146 +L+ E+N++ L++E ++ + ++ + +DK + SL Sbjct: 1124 DSVSKAVSDADRQRILELEKNEMELKVEVSKLREISDIARRQVEILNAQQQSRDKEVESL 1183 Query: 1147 KEELI--FAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQ 1204 + +L+ AQ ++ + K+HQ + ++ T +GKL+ S+ LQ Sbjct: 1184 RMQLLDYQAQSDEKSLIAKLHQHNVSLQLSEATA---------LGKLESITSK-----LQ 1229 Query: 1205 TLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVT 1264 + E Y L+ E ++KE + Y + R +Q + L Sbjct: 1230 KM-----EAYN--LRLEQKLDEKEQALYYARLEGRNRAKHLRQTIQSLRRQFSGALPLAQ 1282 Query: 1265 EE-YNKLLV-LQTRLSKIWGQQTDGMKLEFGEENLPKE-ETEFLSIHSQMTNLEDID--- 1318 +E ++K ++ LQ KI + + + EN E E + + ++ L+D Sbjct: 1283 QEKFSKTMIQLQNDKLKIMQEMKNSQQEHRNMENKTLEMELKLKGLEELISTLKDTKGAQ 1342 Query: 1319 --VNHKSKLSSL------------QDLEKTK-LEEQVQELESLISSLQQQLKETEQNYEA 1363 +N K+ L +D E+ K L + E E ISSL++++ + + +E Sbjct: 1343 KVINWHMKIEELRLQELKLNRELVKDKEEIKYLNNIISEYERTISSLEEEIVQQNKFHEE 1402 Query: 1364 ------------------------EIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRT 1399 EI ++ + + S PSLP+ + + E ++ Sbjct: 1403 RQMAWDQREVDLERQLDIFDRQQNEILNAAQKFEEATGSIPDPSLPLPNQL--EIALRK- 1459 Query: 1400 MYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVA----KVIVSMSI-- 1453 +K+NI +E EE KL EK+ +L E+ KVI + + Sbjct: 1460 ------IKENIRIILETRATCKSLEE----KLKEKESALRLAEQNILSRDKVINELRLRL 1509 Query: 1454 -AFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFN-EMKLSQDQIGFQTFETVDVKFK 1511 A A++ +L G KE K H + Q N + +L+Q + + ++ + K + Sbjct: 1510 PATAEREKLIAELGRKE--MEPKSHHTLKIAHQTIANMQARLNQKEEVLKKYQRLLEKAR 1567 Query: 1512 EEFKPLSKELGE-----HGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIH 1566 EE + + K+ E H + L ++S + ++ ++ S +K FI + Sbjct: 1568 EEQREIVKKHEEDLHILHHRLELQADSSLNKFKQTAWDLMKQSPTPVPTNKHFI--RLAE 1625 Query: 1567 DEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQL 1626 E +V+ D S +L +L+ + Q+L RQ + + + ++ E ++ +++ Sbjct: 1626 MEQTVAEQDDSLSSLL--VKLKKVSQDLERQREITELKVKEFENIKLQLQENHEDEVKKV 1683 Query: 1627 QEEIKRLNRQLAQRSSIDNENLVSERE--------------RVLLEELE---ALKQLSLA 1669 + E++ L + L +S +++ L SE + R L+E L+ ALK+ Sbjct: 1684 KAEVEDL-KYLLDQSQKESQCLKSELQAQKEANSRAPTTTMRNLVERLKSQLALKEKQQK 1742 Query: 1670 GREKLCCELRNSSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANN 1729 + ELR T E +KE + + + ++ N Sbjct: 1743 ALSRALLELRAEMTAAAE------ERIISATSQKEAHLNVQQIVDRHTRELKTQVEDLNE 1796 Query: 1730 RLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTR 1789 LLK L E +KT+ E ++ ++ + + K Q + + I R + E + ++E R Sbjct: 1797 NLLK-LKEALKTSKNRENSLTDNLNDLNNELQKKQKAYNKILREKEEIDQE---NDELKR 1852 Query: 1790 VTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEE------LM 1843 G + N ++ ++ + +L +L ++ P E+ + Sbjct: 1853 QIKRLTSGLQGKPLTDNKQSLIEELQRKVKKLENQL-EGKVEEVDLKPMKEKNAKEELIR 1911 Query: 1844 LNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERL 1903 + QA +E + + E ++ Q +++ F + + E L Q +L+ Sbjct: 1912 WEEGKKWQAKIEGIRNKLKEKEGEV-FTLTKQLNTLKDLFAKADK--EKLTLQRKLK--- 1965 Query: 1904 HEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELE 1963 + V+ ++ + + L +R + + DI+ + L + +++L Sbjct: 1966 ------TTGMTVDQVLGIRALESEKELEELKKRNLDLENDILYMRAHQALPRDSVVEDLH 2019 Query: 1964 AEQQQIQEERELLSRQKEAMKAEAGPV-----------EQQLLQETEKLMKEKLEVQCQA 2012 + + +QE+ L +Q + EQ+L +E KL E +E++ Q Sbjct: 2020 LQNRYLQEKLHALEKQFSKDTYSKPSISGIESDDHCQREQELQKENLKLSSENIELKFQL 2079 Query: 2013 EKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQA------LEKQLEKMR 2066 E+ DL + +K D++E + + E +L +R ++ LEK + M+ Sbjct: 2080 EQANKDLPR-LKNQVRDLKEMCEFLKKEKAEVQRKLGHVRGSGRSGKTIPELEKTIGLMK 2138 Query: 2067 KFLDEQAIDREHER------DVFQQEIQKLEQQ-LKVVPRFQPISEHQTREVEQLANHLK 2119 K +++ + RE+E+ + +++ +EQ+ K+ + + H QL+ H + Sbjct: 2139 KVVEK--VQRENEQLKKASGILTSEKMANIEQENEKLKAELEKLKAHLG---HQLSMHYE 2193 Query: 2120 EKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELE------QALLVEDRKHFGAVEA 2173 KT +++ E+L++++++ + EKL LE L E K E+ Sbjct: 2194 SKTKGTEKIIAENERLRKELKKETDAAEKLRIAKNNLEILNEKMTVQLEETGKRLQFAES 2253 Query: 2174 K-PELS---------------LEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEE 2217 + P+L E +L+ I +K + IT+L++ +++ E + N+ Sbjct: 2254 RGPQLEGADSKSWKSIVVTRMYETKLKELETDIAKKNQSITDLKQLVKEATEREQKVNKY 2313 Query: 2218 VQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQ 2277 + L Q++I K + E + + K +++ L LA + D + H + Q Sbjct: 2314 NEDLEQQIKILK-----HVPEGAETEQGLKRELQVLRLANHQLDKEKAELIHQIEANKDQ 2368 Query: 2278 IIQEKEV-EIDQLNEQVTKLQQQLKITTDNK--VIEEKNELIRDLETQIECLMSDQECVK 2334 E + + DQL E++ L+ QLK++ K + EE +L ++LE + E +K Sbjct: 2369 SGAESTIPDADQLKEKIKDLETQLKMSDLEKQHLKEEIKKLKKELENFDPSFFEEIEDLK 2428 Query: 2335 RNREEEIEQ---LNEVIEKLQQEL 2355 N +EE+++ L E ++KL ++L Sbjct: 2429 YNYKEEVKKNILLEEKVKKLSEQL 2452 Score = 222 bits (565), Expect = 6e-57 Identities = 494/2629 (18%), Positives = 1106/2629 (42%), Gaps = 377/2629 (14%) Query: 290 KKEDFTMQISFLQEKIKVYEMEQDKK---------VENSNKEEIQEKETIIEELNTKIIE 340 ++E+ + K++V E++ +K+ ++ K + QE E +EE+ E Sbjct: 20 RQEELADNLLISLSKVEVNELKSEKQENVIHLFRITQSLMKMKAQEVELALEEVEKAGEE 79 Query: 341 EEK-------KTLELKDKLTTADKLLG------------ELQEQIVQKNQEIKNMKLELT 381 + K K ++L+++L A + G +L++Q+ QK++E+++M+ EL Sbjct: 80 QAKFENQLKTKVMKLENELEMAQQSAGGRDTRFLRNEICQLEKQLEQKDRELEDMEKEL- 138 Query: 382 NSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMY 441 +KE++ +E QL EE + N K ++R + ++K EQL ++ + Y Sbjct: 139 ---EKEKKVNE---QLALRNEEAENENSK--------LRRENKRLKKKNEQLCQDIID-Y 183 Query: 442 GQQIVQMKQELI--RQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELN 499 +QI K+ L+ R + ++ E+ L +T ++I++ N E+ Sbjct: 184 QKQIDSQKETLLSRRGEDSDYRSQLSKKNYELIQYLDEIQTLTEANEKIEVQN---QEMR 240 Query: 500 IKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLN 559 L+++ + EK+ +E + A+ Q ++++++L + Q Q + + N Sbjct: 241 KNLEESVQEMEKMTDEYNRMK----AIVHQTDNVIDQLKKENDHYQLQVQELTDLLKSKN 296 Query: 560 EAHKSLSTVEDLKAE---IVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAE 616 E + + K E ++ +S+ + +E + K+K L+ +K+ V+ Sbjct: 297 EEDDPIMVAVNAKVEEWKLILSSKDDEIIEYQQMLHNLREKLKNAQLDADKSNVMALQQG 356 Query: 617 SQEAELE-RLRTQLLFSHEEELSK---LKEDL--EIEHRINIEKLKDNLGIHYKQQIDGL 670 QE + + ++ T+ + + +E+ K + EDL E++ L + + +D L Sbjct: 357 IQERDSQIKMLTEQVEQYTKEMEKNTCIIEDLKNELQRNKGASTLSQQTHMKIQSTLDIL 416 Query: 671 QNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEI 730 + + + T + + + K +L+ + +LKD + + E+ ++I + +I+I Sbjct: 417 KEKTKEAERTAELAEADAREKDKELVEALKRLKDYESGVYGL--EDAVVEIKNCKNQIKI 474 Query: 731 LRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKD----EKKT 786 +E E+L K++ N L+ K + EN L++ E KT Sbjct: 475 RDRE-----------------IEILTKEI----NKLELKISDFLDENEALRERVGLEPKT 513 Query: 787 LEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQ 846 + D+ + +++ + ++++ + KEIE L EE DLK++ Q+ +E K+ Sbjct: 514 MIDLTEFRNSKHLKQQ-------QYRAENQILLKEIESLEEERLDLKKKIRQMAQERGKR 566 Query: 847 RNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKL---KALNEELHLQ 903 T + ++N E + + + K DL KN E + K++ + + +E L+ Sbjct: 567 SATSGLTTE--DLNLTENISQGDRISERKLDLLSLKNMSEAQSKNEFLSRELIEKERDLE 624 Query: 904 RINPTTVKMKSSV---FDEDKTF---VAETLEMGEVVEKD-------TTELMEKLE---- 946 R K ++ + +E+K + E L+ + ++KD T+ ++ LE Sbjct: 625 RSRTVIAKFQNKLKELVEENKQLEEGMKEILQAIKEMQKDPDVKGGETSLIIPSLERLVN 684 Query: 947 -VTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNR 1005 + + + L Q+ Q G L +E++ ++E S + + + I+H Sbjct: 685 AIESKNAEGIFDASLHLKAQVDQLTGRNEELRQELRESRKEAINYSQQLAKANLKIDHLE 744 Query: 1006 AENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEES 1065 E ++ S+++ + + A S S +N ++ E + + + E+S Sbjct: 745 KETSLLRQSEGSNVVFKGIDLPDGIAPSSASIINSQNEYLIHLLQELENKEKKLKNLEDS 804 Query: 1066 KQEQ----LILDHLPSVTKESSL--RATQPSENDKLQKELNVLKSEQNDLRLQMEAQRIC 1119 ++ ++ H S+ + L + T +E+ +++E L+ + ++++ Sbjct: 805 LEDYNRKFAVIRHQQSLLYKEYLSEKETWKTESKTIKEEKRKLEDQVQQDAIKVKEYNNL 864 Query: 1120 LSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGD 1179 L+ + + + EN + + + E+ + Q + EL++ + E + K + Sbjct: 865 LNALQMDSDEMKKILAENSRKITVLQVNEKSLIRQYTTLVELERQLRKENEKQKNELLSM 924 Query: 1180 EGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENED 1239 E + IG LQ+ E + + L V+ + + N + E + Y + Sbjct: 925 EAEVCEK-IGCLQR-FKEMAIFKIAALQKVVDNSVSLSELELANKQYNELTAKYRDILQK 982 Query: 1240 PELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTR----LSKIWGQQTDGMKLEFGEE 1295 + R + E + L + E NK L + + + W Q+T + G E Sbjct: 983 DNMLVQRTSNLEHLECENISLKEQVESINKELEITKEKLHTIEQAWEQET-----KLGNE 1037 Query: 1296 NLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQEL-ESLISSLQQQL 1354 + + + +TN + + ++ K + +++L + + E Q++ E L +SL+Q Sbjct: 1038 SSMDKAKK------SITNSDIVSISKKITMLEMKELNERQRAEHCQKMYEHLRTSLKQM- 1090 Query: 1355 KETEQNYE-----AEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKN 1409 E+N+E AE+ + Q V + S ++++D QR + K Sbjct: 1091 --EERNFELETKFAELTKINLDAQKVEQMLRDELADSVSKAVSDADRQRIL---ELEKNE 1145 Query: 1410 IDGTIEFSGEFGVKEETNI----VKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRIS 1465 ++ +E S ++E ++I V++L Q Q + ++EV + + + AQ E S I+ Sbjct: 1146 MELKVEVSK---LREISDIARRQVEILNAQQQSR-DKEVESLRMQLLDYQAQSDEKSLIA 1201 Query: 1466 GGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEF--KPLSKELGE 1523 ++ S + + A + + + + +D K + + + + + Sbjct: 1202 KLHQHNVSLQLSEATALGKLESITSKLQKMEAYNLRLEQKLDEKEQALYYARLEGRNRAK 1261 Query: 1524 HGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLN 1583 H ++ + S + + +E FSK T I Q+ +I ++ ++ Sbjct: 1262 HLRQTIQSLRR-----QFSGALPLAQQEKFSK--TMIQLQNDKLKIMQEMKNSQQEHRNM 1314 Query: 1584 EEQLEDMR------QELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQL 1637 E + +M +EL+ ++ + A +++ HM+ E+L+ + +LNR+L Sbjct: 1315 ENKTLEMELKLKGLEELISTLKDTKGAQKVINW-HMKI--------EELRLQELKLNREL 1365 Query: 1638 AQRSSIDN--ENLVSERERVL--LEELEALKQLSLAGREKLCCELRNSSTQTQNG--NEN 1691 + N++SE ER + LEE E ++Q ++ + R + Q + Sbjct: 1366 VKDKEEIKYLNNIISEYERTISSLEE-EIVQQNKFHEERQMAWDQREVDLERQLDIFDRQ 1424 Query: 1692 QGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGR 1751 Q E+ K +E D + + AL+K + +I+LE T ++EE + Sbjct: 1425 QNEILNAAQKFEEATGSIPDPSLPLPNQLEIALRKIKENI-RIILETRATCKSLEEKLKE 1483 Query: 1752 H--VLGILDRSSKSQSSA--SLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRND 1807 L + +++ S+ L R A A + + E + + S+ + Sbjct: 1484 KESALRLAEQNILSRDKVINELRLRLPATAEREKLIAELGRKEMEPK--SHHTLKIAHQT 1541 Query: 1808 I-NMWSKVT--EEGTELSQRLV-RSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISE 1863 I NM +++ EE + QRL+ ++ EI ++EE + + RL+ + L + Sbjct: 1542 IANMQARLNQKEEVLKKYQRLLEKAREEQREIVKKHEEDLHILHHRLELQADSSLNKFKQ 1601 Query: 1864 TSSQLEHAKVTQTEL---------MRESFRQKQEATESLKCQEELRERLHEESRAREQLA 1914 T+ L T M ++ ++ ++ SL + L++ + R RE Sbjct: 1602 TAWDLMKQSPTPVPTNKHFIRLAEMEQTVAEQDDSLSSLLVK--LKKVSQDLERQREITE 1659 Query: 1915 VELSKAEGVI----DGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQ---------- 1960 +++ + E + + + DE + ++++ ++D+ ++E C + LQ Sbjct: 1660 LKVKEFENIKLQLQENHEDEVKKVKAEVEDLKYLLDQSQKESQCLKSELQAQKEANSRAP 1719 Query: 1961 ---------ELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQ 2011 L+++ +++++ LSR ++AE ++ + + L VQ Sbjct: 1720 TTTMRNLVERLKSQLALKEKQQKALSRALLELRAEMTAAAEERIISATSQKEAHLNVQQI 1779 Query: 2012 AEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDE 2071 ++ +L+ QV+ L ++ + + +N+ +L N L+K+ + K L E Sbjct: 1780 VDRHTRELKTQVEDLNENLLKLKEALKTSKNRENSLTDNLNDLNNELQKKQKAYNKILRE 1839 Query: 2072 QAIDREHERDVFQQEIQKLEQQLKVVP---RFQPISEHQTREVEQLANHLKEKTDKCSEL 2128 + + + E D +++I++L L+ P Q + E R+V++L N L+ K ++ +L Sbjct: 1840 KE-EIDQENDELKRQIKRLTSGLQGKPLTDNKQSLIEELQRKVKKLENQLEGKVEEV-DL 1897 Query: 2129 LLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVEDRKHFGAVEAKPELSLEVQLQAERD 2188 KE+ ++ R EE +K + ++ + L ++ + F +L QL +D Sbjct: 1898 KPMKEKNAKEELIRWEEGKKWQAKIEGIRNKLKEKEGEVF---------TLTKQLNTLKD 1948 Query: 2189 AIDRKEKEITNLEEQL------------------EQFREELENKNEEVQQ--LHMQLEIQ 2228 + +KE L+ +L E+ EEL+ +N +++ L+M+ Q Sbjct: 1949 LFAKADKEKLTLQRKLKTTGMTVDQVLGIRALESEKELEELKKRNLDLENDILYMRAH-Q 2007 Query: 2229 KKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQ 2288 + +++L +N+ ++ + A+++ + T + + G + ++E E+ + Sbjct: 2008 ALPRDSVVEDLHLQNRYLQEKLH----ALEKQFSKDTYSKPSISGIESDDHCQREQELQK 2063 Query: 2289 LNEQVTKLQQQLKITTD--NKVIEEKNELIRDLETQIECLMSDQECVKRNR--------- 2337 N +++ +LK + NK + +RDL+ E L ++ V+R Sbjct: 2064 ENLKLSSENIELKFQLEQANKDLPRLKNQVRDLKEMCEFLKKEKAEVQRKLGHVRGSGRS 2123 Query: 2338 -------EEEIEQLNEVIEKLQQELANI----GQKTSMNAHSLSEEADSLKHQLDVV--- 2383 E+ I + +V+EK+Q+E + G TS ++ +E + LK +L+ + Sbjct: 2124 GKTIPELEKTIGLMKKVVEKVQRENEQLKKASGILTSEKMANIEQENEKLKAELEKLKAH 2183 Query: 2384 IAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSV 2443 + +L++ + +T E +N +L +EL K+E ++ EK++ I +N++ Sbjct: 2184 LGHQLSMHYESKTKGTEKIIAEN---------ERLRKEL---KKETDAAEKLR-IAKNNL 2230 Query: 2444 NVAIDHLSKDKPELEVVLTEDALKSLENQ-TYFKSFEENGKGSII---NLETRLLQLEST 2499 + +K +++ T L+ E++ + + SI+ ET+L +LE+ Sbjct: 2231 EIL-----NEKMTVQLEETGKRLQFAESRGPQLEGADSKSWKSIVVTRMYETKLKELETD 2285 Query: 2500 VSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEY 2559 ++ K+ +T + +K+ E+ ++K+ + +E+++ L+ V E Sbjct: 2286 IAKKNQSITDLKQLVKEATER--------EQKVNKYNEDLEQQIKI-------LKHVPEG 2330 Query: 2560 AKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKE 2619 A+ E L ++ L L +L+ + E+ + K+ Sbjct: 2331 AE-----------------------TEQGLKRELQVLRLANHQLDKEKAELIHQIEANKD 2367 Query: 2620 Q----VEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNE 2675 Q I + + L+++ K LE Q + EK+ ++E K+ +++E N Sbjct: 2368 QSGAESTIPDADQLKEKIKDLETQLKMSDLEKQHLKEEIKKLKKELE-----------NF 2416 Query: 2676 ESGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKD 2724 + FF E+E L+ + +EK +KL E+L V+ T+ + ++ Sbjct: 2417 DPSFFEEIEDLKYNYKEEVKKNILLEEKVKKLSEQLGVELTSPVAASEE 2465 Score = 181 bits (458), Expect = 2e-44 Identities = 394/1983 (19%), Positives = 841/1983 (42%), Gaps = 262/1983 (13%) Query: 1837 PENEELMLNISSRLQAAVEKLLEAISETSSQLEHA-KVTQTELMRESFRQKQEATESLKC 1895 P EEL N+ L ++ E SE + H ++TQ+ + K +A E Sbjct: 19 PRQEELADNLLISLSKV--EVNELKSEKQENVIHLFRITQSLM-------KMKAQEVELA 69 Query: 1896 QEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCA 1955 EE+ + E+++ QL ++ K E ++ +++ R + + I +LE++L Sbjct: 70 LEEVEKAGEEQAKFENQLKTKVMKLENELE--MAQQSAGGRDTRFLRNEICQLEKQLEQK 127 Query: 1956 SNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQ---LLQETEKLMKEKLEVQCQA 2012 L+++E E ++ ++ E L+ + E + E + ++ L ++ E+L ++ ++ Q Q Sbjct: 128 DRELEDMEKELEKEKKVNEQLALRNEEAENENSKLRRENKRLKKKNEQLCQDIIDYQKQI 187 Query: 2013 EKVRDDLQKQVKALEIDVEEQVSRF-IELEQEKNTELMDLRQQNQALEKQLEKMRKFLDE 2071 + ++ L + + + D Q+S+ EL Q + E+ L + N+ +E Q ++MRK L+E Sbjct: 188 DSQKETLLSR-RGEDSDYRSQLSKKNYELIQYLD-EIQTLTEANEKIEVQNQEMRKNLEE 245 Query: 2072 QAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLS 2131 + E D + + + Q V+ + + ++H +V++L + LK K ++ ++++ Sbjct: 246 SVQEMEKMTDEYNRMKAIVHQTDNVIDQLKKENDHYQLQVQELTDLLKSKNEEDDPIMVA 305 Query: 2132 ----KEQLQRDIQERNEEI---EKLEFRVRE-LEQALLVEDRKHFGAVEAKPELSLEVQL 2183 E+ + + +++EI +++ +RE L+ A L D+ + + Sbjct: 306 VNAKVEEWKLILSSKDDEIIEYQQMLHNLREKLKNAQLDADKSN---------------V 350 Query: 2184 QAERDAIDRKEKEITNLEEQLEQFREELEN--------KNE---------EVQQLHMQLE 2226 A + I ++ +I L EQ+EQ+ +E+E KNE QQ HM+++ Sbjct: 351 MALQQGIQERDSQIKMLTEQVEQYTKEMEKNTCIIEDLKNELQRNKGASTLSQQTHMKIQ 410 Query: 2227 I------QKKESTTRLQELEQENKLFKDDMEKLGLAIK-----ESDAMSTQDQHVLFGKF 2275 +K + R EL + + KD ++L A+K ES +D V Sbjct: 411 STLDILKEKTKEAERTAELAEADAREKD--KELVEALKRLKDYESGVYGLEDAVVEIKNC 468 Query: 2276 AQIIQEKEVEIDQLNEQVTKLQQQLK-ITTDNKVIEEKNELIRDLETQIECLMSDQECVK 2334 I+ ++ EI+ L +++ KL+ ++ +N+ + E+ L + + + + Sbjct: 469 KNQIKIRDREIEILTKEINKLELKISDFLDENEALRERVGLEPKTMIDLTEFRNSKHLKQ 528 Query: 2335 RNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSE-EADSLKHQLDVVIAEKLALEQQ 2393 + E + L + IE L++E ++ +K A + A S D+ + E ++ + Sbjct: 529 QQYRAENQILLKEIESLEEERLDLKKKIRQMAQERGKRSATSGLTTEDLNLTENISQGDR 588 Query: 2394 VETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKD 2453 + ++ +KN + E K L++EL +R+ E + + +N + ++ + Sbjct: 589 ISERKLDLLSLKN-MSEAQSKNEFLSRELIEKERDLERSRTVIAKFQNKLKELVEENKQL 647 Query: 2454 KPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQ 2513 + ++ +L A+K ++ K G+ S+I + LE V+A Sbjct: 648 EEGMKEIL--QAIKEMQKDPDVK----GGETSLI-----IPSLERLVNA----------- 685 Query: 2514 IKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEP 2573 I+ +G F+ + K V+ E++ L + + EA+ + + N I Sbjct: 686 IESKNAEGIFDASLHLKAQVDQLTGRNEELRQEL-RESRKEAINYSQQLAKANLKIDHLE 744 Query: 2574 ERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLE-KE 2632 + T++ LR+ E GS++ + +L + S+I + + I LE KE Sbjct: 745 KETSL-----LRQSE-GSNV---VFKGIDLPDGIAPSSASIINSQNEYLIHLLQELENKE 795 Query: 2633 KKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVA 2692 KKL L+ LE +K V++ L + + +E E + ES Sbjct: 796 KKLKNLEDSLEDYNRK------------FAVIRHQQSLLYKE----YLSEKETWKTESKT 839 Query: 2693 TKAELASYKEKAEKLQEELLVKETN--MTSLQKDLSQVRDHLAEAKEKLSILEKEDETEV 2750 K E +++ + Q+ + VKE N + +LQ D +++ LAE K+++L+ +++ + Sbjct: 840 IKEEKRKLEDQVQ--QDAIKVKEYNNLLNALQMDSDEMKKILAENSRKITVLQVNEKSLI 897 Query: 2751 QESKKACMFEPLPIKLSKS-----IASQTDGTLKISSSNQTPQILV-KNAGIQINLQSEC 2804 ++ E K ++ ++ + + KI + ++ + K A +Q + + Sbjct: 898 RQYTTLVELERQLRKENEKQKNELLSMEAEVCEKIGCLQRFKEMAIFKIAALQKVVDNSV 957 Query: 2805 SSEEVTEIISQFTEKIEKMQEL---------HAAEILDMESRHIS----------ETETL 2845 S E+ Q+ E K +++ + + +E +IS E E Sbjct: 958 SLSELELANKQYNELTAKYRDILQKDNMLVQRTSNLEHLECENISLKEQVESINKELEIT 1017 Query: 2846 KREHYVAVQLLKEE--CGTLKAVIQCLRSKEGSSIPELAHSDAYQTREICSSDSGSDWGQ 2903 K + + Q ++E G ++ + +S S I ++ + + ++ Q Sbjct: 1018 KEKLHTIEQAWEQETKLGNESSMDKAKKSITNSDIVSISKKITMLEMKELNERQRAEHCQ 1077 Query: 2904 GIYLTHSQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDH 2963 +Y H + E R E E+ F + K L A E M L +S D Sbjct: 1078 KMY-EHLRTSLKQMEERNFELET---KFAELTKINLDAQKVEQMLRDELADSVSKAVSDA 1133 Query: 2964 SIQQVSEPWLE----ERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELL 3019 Q++ E LE E K ++ + + D+ +R+ E+ ++ Q + Sbjct: 1134 DRQRILE--LEKNEMELKVEVSKLREISDI-----ARRQVEILNAQQQSRDKEVESLRMQ 1186 Query: 3020 LALQQVFLEERSVLLAAFR-------TELTALGTTDAV--------GLLNCLEQRIQE-Q 3063 L Q +E+S++ + +E TALG +++ LEQ++ E + Sbjct: 1187 LLDYQAQSDEKSLIAKLHQHNVSLQLSEATALGKLESITSKLQKMEAYNLRLEQKLDEKE 1246 Query: 3064 GVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQS 3123 Y A +E +A + L IQ+L Q +G + L ++++ K +L ++ Q Sbjct: 1247 QALYYARLEGRNRA--KHLRQTIQSLRRQFSG-ALPLAQQEKFSKTMIQLQNDKLKIMQ- 1302 Query: 3124 QMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEA 3183 +M Q E +M+++ E++ +L + +++ LK K+ + +K + L+EL+ Sbjct: 1303 EMKNSQQEHRNMENKTLEMELKLKGLEELISTLKDTKGAQKV-INWHMKIEELRLQELKL 1361 Query: 3184 FRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLES 3243 R VKDK +E+ LN+ ++ ++ +LE+E + + E + + + LE Sbjct: 1362 NRELVKDK-EEIKYLNNIISEYERTIS----SLEEEIVQQNKFHEERQMAWDQREVDLER 1416 Query: 3244 QKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIRE 3303 QL++ QQ ++LN +Q+ E+ + D L + L+ + E+ ++ + Sbjct: 1417 ------QLDIFDRQQNEILNAAQKFEEATGSIPDPSLPLPNQLEIALRKIKENIRIILET 1470 Query: 3304 MSSTLDRERELHAQ-----------LQSSDGTGQSRPPLPS----EDLLKEL-QKQLEEK 3347 ++ E +L + L + R LP+ E L+ EL +K++E K Sbjct: 1471 RATCKSLEEKLKEKESALRLAEQNILSRDKVINELRLRLPATAEREKLIAELGRKEMEPK 1530 Query: 3348 HSRIVELLNETEKYKLDSLQTRQQ-MEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVED 3406 +++ ++T L +++ ++K +++ K + ++E + ++ +H L ++E Sbjct: 1531 SHHTLKIAHQTIANMQARLNQKEEVLKKYQRLLEKAREEQREIVKKHEEDLHILHHRLE- 1589 Query: 3407 LQRQLEEKRQQVYKLDLEGQRLQGI--------MQEFQKQELEREEKRESRRILYQNLNE 3458 LQ + + DL Q + + E ++ E+++ S + + +++ Sbjct: 1590 LQADSSLNKFKQTAWDLMKQSPTPVPTNKHFIRLAEMEQTVAEQDDSLSSLLVKLKKVSQ 1649 Query: 3459 --PTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMIRQKLQCVAS 3516 +T + + + + I+ + +E++ ++ ++ + L+ +++ QC+ S Sbjct: 1650 DLERQREITELKVKEF---ENIKLQLQENHEDEVKKVKAEVEDLKYLLDQSQKESQCLKS 1706 Query: 3517 KLQVLPQKAS-----------ERLQFETADDEDFIWVQENIDEIILQLQKLTGQQGEEPS 3565 +LQ + S ERL+ + A E Q+ + +L+L+ EE Sbjct: 1707 ELQAQKEANSRAPTTTMRNLVERLKSQLALKEK---QQKALSRALLELRAEMTAAAEERI 1763 Query: 3566 LVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKLEEQIRWYRQTGAGRDNS 3625 + S S E L + H +L + DL ++KL+E ++ T R+NS Sbjct: 1764 I-----SATSQKEAHLNVQQIVDRHTRELKTQVEDLNENLLKLKEALK----TSKNRENS 1814 Query: 3626 SRFSLNGGAN-------IEAIIASEKEVWNREKLTLQKSLKRAEAEVYKLKAELRNDSLL 3678 +LN N I EKE ++E L++ +KR + + SL+ Sbjct: 1815 LTDNLNDLNNELQKKQKAYNKILREKEEIDQENDELKRQIKRLTSGLQGKPLTDNKQSLI 1874 Query: 3679 QTL 3681 + L Sbjct: 1875 EEL 1877 Score = 177 bits (450), Expect = 1e-43 Identities = 520/2691 (19%), Positives = 1103/2691 (40%), Gaps = 458/2691 (17%) Query: 932 EVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSL-KQEKEQV 990 E+++ D +L + E+ + LS+ +++E +K + L +SL K + ++V Sbjct: 9 EIMKVDPDDLPRQEELADNLLISLSK--VEVNELKSEKQENVIHLFRITQSLMKMKAQEV 66 Query: 991 SLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKV--NKSFGEESKI 1048 L E+E +A+ T+V L + + M + A G ++ N+ E ++ Sbjct: 67 ELALEEVEKA-GEEQAKFENQLKTKVMKL-ENELEMAQQSAGGRDTRFLRNEICQLEKQL 124 Query: 1049 MVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQND 1108 +D+ E+M +E ++E+ + + L +E+ +EN KL++E + Sbjct: 125 EQKDR-ELEDME--KELEKEKKVNEQLALRNEEAE------NENSKLRRE---------N 166 Query: 1109 LRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQL- 1167 RL+ + +++C ++ ++ ++++K+ L E+ + + K + I L Sbjct: 167 KRLKKKNEQLCQDII------DYQKQIDSQKETLLSRRGEDSDYRSQLSKKNYELIQYLD 220 Query: 1168 ELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDK 1227 E+QT+ + + + + +++K + E +Q + + EY +K V+ D Sbjct: 221 EIQTLT-----EANEKIEVQNQEMRKNLEES----VQEMEKMTDEYNR--MKAIVHQTD- 268 Query: 1228 ENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDG 1287 N D + + D Y+ +VQ+ + LL EE + ++V Sbjct: 269 -NVIDQLKKEND----HYQLQVQELTD----LLKSKNEEDDPIMVAVNA----------- 308 Query: 1288 MKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQ-DLEKTK---LEEQVQEL 1343 K+E + L ++ E + + NL + KL + Q D +K+ L++ +QE Sbjct: 309 -KVEEWKLILSSKDDEIIEYQQMLHNLRE-------KLKNAQLDADKSNVMALQQGIQER 360 Query: 1344 ESLISSLQQQLKETEQNYEAE---IHCLQKRLQ------AVSEST-VPPSLPVDSVVITE 1393 +S I L +Q+++ + E I L+ LQ +S+ T + +D + Sbjct: 361 DSQIKMLTEQVEQYTKEMEKNTCIIEDLKNELQRNKGASTLSQQTHMKIQSTLDILKEKT 420 Query: 1394 SDAQRTMYPGSCVKKNIDGTIEF---------SGEFGVKEETNIVKLLEKQYQ------E 1438 +A+RT + D + SG +G+++ +K + Q + E Sbjct: 421 KEAERTAELAEADAREKDKELVEALKRLKDYESGVYGLEDAVVEIKNCKNQIKIRDREIE 480 Query: 1439 QLEEEVAKVIVSMSIAFAQQTELSRISGGKE-----NTASSKQAHAVCQQEQHYFNEMKL 1493 L +E+ K+ + +S F + E R G E + + + + QQ+ N++ L Sbjct: 481 ILTKEINKLELKIS-DFLDENEALRERVGLEPKTMIDLTEFRNSKHLKQQQYRAENQILL 539 Query: 1494 SQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEMF 1553 + ++ E + K++ + +++E G+ L+ D + + E+ ISE Sbjct: 540 KE----IESLEEERLDLKKKIRQMAQERGKRSATSGLTTEDLN-LTENISQGDRISERKL 594 Query: 1554 S--KDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQA 1611 K QS ++ +S ++ R L + + + +L +E++Q E +++ Sbjct: 595 DLLSLKNMSEAQSKNEFLSRELIEKERDLERSRTVIAKFQNKLKELVEENKQLEEGMKEI 654 Query: 1612 HMRQMERQREDQEQLQEE---IKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLS- 1667 E Q++ + E I L R + ++I+++N E + L Q+ Sbjct: 655 LQAIKEMQKDPDVKGGETSLIIPSLERLV---NAIESKNA----EGIFDASLHLKAQVDQ 707 Query: 1668 LAGR-EKLCCELRNSSTQTQNGNENQGEVE---EQTFKEKELDRKPE---------DVPP 1714 L GR E+L ELR S + N ++ + + KE L R+ E D+P Sbjct: 708 LTGRNEELRQELRESRKEAINYSQQLAKANLKIDHLEKETSLLRQSEGSNVVFKGIDLPD 767 Query: 1715 EILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSE 1774 I + + N L+ +L E+ ++ L+ S + + + R + Sbjct: 768 GIAPSSASIINSQNEYLIHLLQELENKEKKLKN---------LEDSLEDYNRKFAVIRHQ 818 Query: 1775 AEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTE 1834 K + E+ T T+ + EE +L ++ + E Sbjct: 819 QSLLYKEYLSEKETWKTESKT------------------IKEEKRKLEDQVQQDAIKVKE 860 Query: 1835 IDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRE---------SFRQ 1885 + N+ + LQ +++ + ++E S ++ +V + L+R+ R+ Sbjct: 861 YN--------NLLNALQMDSDEMKKILAENSRKITVLQVNEKSLIRQYTTLVELERQLRK 912 Query: 1886 KQEA--TESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYAD--EKTLFERQIQEK 1941 + E E L + E+ E++ R +E +++ + V+D E L +Q E Sbjct: 913 ENEKQKNELLSMEAEVCEKIGCLQRFKEMAIFKIAALQKVVDNSVSLSELELANKQYNEL 972 Query: 1942 T----DIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQE 1997 T DI+ + + L+ ++ L+ LE E ++E+ E ++++ E K + +EQ QE Sbjct: 973 TAKYRDILQK-DNMLVQRTSNLEHLECENISLKEQVESINKELEITKEKLHTIEQAWEQE 1031 Query: 1998 TEKLMKEKLEVQCQAEKVRDDL---QKQVKALE---IDVEEQVSRFIELEQEKNTELMDL 2051 T KL E + + D+ K++ LE ++ ++ ++ + T L + Sbjct: 1032 T-KLGNESSMDKAKKSITNSDIVSISKKITMLEMKELNERQRAEHCQKMYEHLRTSLKQM 1090 Query: 2052 RQQNQALEKQLEKMRKF-LDEQAID---REHERDVFQQ-----------EIQKLEQQLKV 2096 ++N LE + ++ K LD Q ++ R+ D + E++K E +LKV Sbjct: 1091 EERNFELETKFAELTKINLDAQKVEQMLRDELADSVSKAVSDADRQRILELEKNEMELKV 1150 Query: 2097 -VPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRE 2155 V + + IS+ R+VE +L+ +Q RD + + ++ L+++ + Sbjct: 1151 EVSKLREISDIARRQVE----------------ILNAQQQSRDKEVESLRMQLLDYQAQS 1194 Query: 2156 LEQALLVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQ-----FREE 2210 E++L+ + +H +++ +L +L++ + + E LE++L++ + Sbjct: 1195 DEKSLIAKLHQHNVSLQLSEATALG-KLESITSKLQKMEAYNLRLEQKLDEKEQALYYAR 1253 Query: 2211 LENKN------EEVQQLHMQ------LEIQKKESTTRLQ-------------ELEQENKL 2245 LE +N + +Q L Q L Q+K S T +Q +QE++ Sbjct: 1254 LEGRNRAKHLRQTIQSLRRQFSGALPLAQQEKFSKTMIQLQNDKLKIMQEMKNSQQEHRN 1313 Query: 2246 FKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTD 2305 ++ ++ L +K + + + + K AQ + ++I++L Q KL ++L D Sbjct: 1314 MENKTLEMELKLKGLEELISTLKDT---KGAQKVINWHMKIEELRLQELKLNREL--VKD 1368 Query: 2306 NKVIEEKNELIRDLETQIECLMSDQECVKRN------------REEEIEQLNEVIEKLQQ 2353 + I+ N +I + E I L ++E V++N RE ++E+ ++ ++ Q Sbjct: 1369 KEEIKYLNNIISEYERTISSL--EEEIVQQNKFHEERQMAWDQREVDLERQLDIFDRQQN 1426 Query: 2354 ELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNF 2413 E+ N QK S+ + + L +QL++ + + +++ + ++ ET Sbjct: 1427 EILNAAQKFEEATGSIPDPSLPLPNQLEIALRK---IKENIR-----------IILETRA 1472 Query: 2414 KMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKP---ELEVVLTEDALKSLE 2470 L ++L +E+ES ++ S + I+ L P E E ++ E K +E Sbjct: 1473 TCKSLEEKL----KEKESALRLAEQNILSRDKVINELRLRLPATAEREKLIAELGRKEME 1528 Query: 2471 NQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQK 2530 +++ + +I N++ RL Q E + K+ + + E+ + E + K Sbjct: 1529 PKSHHTL--KIAHQTIANMQARLNQKEEVL-----------KKYQRLLEKAREEQREIVK 1575 Query: 2531 KIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELG 2590 K E+ L +++L+A KF Q + + N + +R E+ Sbjct: 1576 K--------HEEDLHILHHRLELQADSSLNKFKQTAWDLMKQSPTPVPTNKHFIRLAEME 1627 Query: 2591 SDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQR 2650 ++ +S L ++ ++ L + Q EI E V E E L+LQ+ Sbjct: 1628 QTVAEQDDSLSSLLVKLKKVSQDL---ERQREITELKVKEFENIKLQLQE--------NH 1676 Query: 2651 EKEKKRSPQDVEVLKTTTELFHSNEESGFF-NELEALRAESVATKAELASYKEKAEKLQE 2709 E E K+ +VE LK + S +ES +EL+A + + ++A + + E+L+ Sbjct: 1677 EDEVKKVKAEVEDLKYLLD--QSQKESQCLKSELQAQKEAN--SRAPTTTMRNLVERLKS 1732 Query: 2710 ELLVKETNMTSLQKDLSQVRDHLAEAKEKLSIL---EKEDETEVQESKKACMFEPLPIKL 2766 +L +KE +L + L ++R + A E+ I +KE VQ+ + + +L Sbjct: 1733 QLALKEKQQKALSRALLELRAEMTAAAEERIISATSQKEAHLNVQQ-----IVDRHTREL 1787 Query: 2767 SKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTEIISQFTEKIEKMQE- 2825 + + LK+ + +T S+ +T+ ++ +++K Q+ Sbjct: 1788 KTQVEDLNENLLKLKEALKT---------------SKNRENSLTDNLNDLNNELQKKQKA 1832 Query: 2826 ----LHAAEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPEL 2881 L E +D E+ + L + ++ + + ++ E ++ Sbjct: 1833 YNKILREKEEIDQENDELKRQIKRLTSGLQGKPLTDNKQSLIEELQRKVKKLENQLEGKV 1892 Query: 2882 AHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIASEG---RGEESESATDSFPKKIKGL 2938 D +E + + W +G + + EG + +E E + K++ L Sbjct: 1893 EEVDLKPMKEKNAKEELIRWEEG------KKWQAKIEGIRNKLKEKEGEVFTLTKQLNTL 1946 Query: 2939 LRAVHNEGMQVLSLTESPYSDGEDHSIQQV-------SEPWLEE-RKAYINTISSLKDLI 2990 + L+L + G ++ QV SE LEE +K ++ + + + Sbjct: 1947 KDLFAKADKEKLTLQRKLKTTGM--TVDQVLGIRALESEKELEELKKRNLDLENDILYMR 2004 Query: 2991 TKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTALGTTDAV 3050 L R++ V D + E L AL++ F ++ + ++ + + D Sbjct: 2005 AHQALPRDSVVEDLHLQNRYLQ----EKLHALEKQFSKD-----TYSKPSISGIESDDHC 2055 Query: 3051 GLLNCLEQ---RIQEQGVEYQAAMECLQKADRRSLLSEIQAL------------------ 3089 L++ ++ + +E + +E K D L ++++ L Sbjct: 2056 QREQELQKENLKLSSENIELKFQLEQANK-DLPRLKNQVRDLKEMCEFLKKEKAEVQRKL 2114 Query: 3090 -HAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSS 3148 H + +GR E E + + +Q++ Q+ + L+S ++ ++++ Sbjct: 2115 GHVRGSGRSGKTIPELEKTIGLMKKVVEKVQRENEQLKKASGILTS--EKMANIEQENEK 2172 Query: 3149 EKMVVAELKSELA-QTKLELETTLKAQHKHLKELEAFRLEVKDKTD----------EVHL 3197 K + +LK+ L Q + E+ K K + E E R E+K +TD + + Sbjct: 2173 LKAELEKLKAHLGHQLSMHYESKTKGTEKIIAENERLRKELKKETDAAEKLRIAKNNLEI 2232 Query: 3198 LNDTLASE-QKKSRELQWA------LEKEKAKLGRS---EERDKEELEDLKFSLESQKQR 3247 LN+ + + ++ + LQ+A LE +K +S + +L++L+ + + Q Sbjct: 2233 LNEKMTVQLEETGKRLQFAESRGPQLEGADSKSWKSIVVTRMYETKLKELETDIAKKNQS 2292 Query: 3248 NLQLNLLLE---QQKQLLNESQQKIESQRML---YDAQLSEEQGRNLELQVLLESEKVRI 3301 L L++ +++Q +N+ + +E Q + EQG ELQVL Sbjct: 2293 ITDLKQLVKEATEREQKVNKYNEDLEQQIKILKHVPEGAETEQGLKRELQVL-------- 2344 Query: 3302 REMSSTLDRER-ELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEK 3360 R + LD+E+ EL Q++++ + +P D LKE K LE + ++ +L E + Sbjct: 2345 RLANHQLDKEKAELIHQIEANKDQSGAESTIPDADQLKEKIKDLETQ-LKMSDL--EKQH 2401 Query: 3361 YKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQL 3411 K + + ++++E + ++ + E KK L+ KV+ L QL Sbjct: 2402 LKEEIKKLKKELENFDPSFFEEIEDLKYNYKEEVKKNILLEEKVKKLSEQL 2452 Score = 177 bits (449), Expect = 2e-43 Identities = 457/2449 (18%), Positives = 1010/2449 (41%), Gaps = 346/2449 (14%) Query: 492 NVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTI 551 N+ I+ +++ + S+K++ L I + ++ Q E+ + E++++A + Sbjct: 27 NLLISLSKVEVNELKSEKQENVIHLFRITQSLMKMKAQ------EVELALEEVEKAGEEQ 80 Query: 552 AEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVL 611 A+ E++L + V L+ E+ A +S + + + N +LE ++K+ L Sbjct: 81 AKFENQLK------TKVMKLENELEMAQQSAGGRDTRF---LRNEICQLEKQLEQKDREL 131 Query: 612 DRMAESQEAELERLRTQLLFSHEE---ELSKLKEDLEIEHRINIEKLKDNLGIHYKQQID 668 + M + E E +++ QL +EE E SKL+ + + + N + +D I Y++QID Sbjct: 132 EDMEKELEKE-KKVNEQLALRNEEAENENSKLRRENKRLKKKNEQLCQDI--IDYQKQID 188 Query: 669 GLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEI 728 +K+ L++++ + S+L L+ E TL E ++I Sbjct: 189 S--------------QKETLLSRRGEDSDYRSQLSKKNYELIQYLDEIQTL--TEANEKI 232 Query: 729 EILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLE 788 E+ QE ++ LE+ VQE++ T+ + MK + QL+ EN + + + L Sbjct: 233 EVQNQEMRKN--LEESVQEMEKMTDEYNR-MKAIVHQTDNVIDQLKKENDHYQLQVQELT 289 Query: 789 DMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRN 848 D+LK EE + ++ +K ++ W+ IL +++++ + L+ EK +N Sbjct: 290 DLLKS----KNEEDDPIMVAVNAKVEE--WKL---ILSSKDDEIIEYQQMLHNLREKLKN 340 Query: 849 TFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPT 908 A+K+ + Q+ +E +K+ + + K+ + ++ L EL Sbjct: 341 AQLDADKSNVMALQQGIQERDSQIKMLTEQVEQYTKEMEKNTCIIEDLKNELQRN----- 395 Query: 909 TVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQ 968 K S++ + + TL++ + K+ E E REK + L + ++LK Sbjct: 396 --KGASTLSQQTHMKIQSTLDILKEKTKEAERTAELAEADAREK---DKELVEALKRLKD 450 Query: 969 KHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTS 1028 + L + V +K K Q+ +R RE+EI+ + + + ++S LD + Sbjct: 451 YESGVYGLEDAVVEIKNCKNQIKIRDREIEIL-----TKEINKLELKISDFLDENEALRE 505 Query: 1029 RGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQ-EQLILDHLPSVTKESSLRAT 1087 R + ++ + SK + + + EN + +E + E+ LD + + + R Sbjct: 506 RVGLEPKTMIDLTEFRNSKHLKQQQYRAENQILLKEIESLEEERLDLKKKIRQMAQERGK 565 Query: 1088 QPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLK 1147 + + + ++LN+ ++ R+ E + LSL + E+ L Sbjct: 566 RSATSGLTTEDLNLTENISQGDRIS-ERKLDLLSLKNMSEAQSKNEF-----------LS 613 Query: 1148 EELIFAQEEKIKELQKIHQLELQTM-KTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTL 1206 ELI EK ++L++ + + K +E +E K L + ++ +A+ E +Q Sbjct: 614 RELI----EKERDLERSRTVIAKFQNKLKELVEENKQLEEGMKEILQAIKE-----MQKD 664 Query: 1207 CSVLG---EYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKV 1263 V G P+L+ VNA + +N+ D L + +V L ++ Sbjct: 665 PDVKGGETSLIIPSLERLVNAIESKNAEGIF----DASLH-LKAQVDQLTGRNEELRQEL 719 Query: 1264 TEEYNKLLVLQTRLSKIWGQQTDGMKLEFGE-ENLPKEETEFLSIHSQMTNLEDIDVNHK 1322 E + + +L+K +K++ E E ++E ++ + +L D Sbjct: 720 RESRKEAINYSQQLAKA------NLKIDHLEKETSLLRQSEGSNVVFKGIDLPDGIAPSS 773 Query: 1323 SKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSESTVPP 1382 + + + Q+ L ++++ E + +L+ L++ + + H Q+ L + Sbjct: 774 ASIINSQNEYLIHLLQELENKEKKLKNLEDSLEDYNRKFAVIRH--QQSLLYKEYLSEKE 831 Query: 1383 SLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEE 1442 + +S I E K+ ++ ++ VKE N++ L+ + Sbjct: 832 TWKTESKTIKEE------------KRKLEDQVQ-QDAIKVKEYNNLLNALQMD-----SD 873 Query: 1443 EVAKVIV--SMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQ-DQIG 1499 E+ K++ S I Q E S I +Q +++++ M+ ++IG Sbjct: 874 EMKKILAENSRKITVLQVNEKSLIRQYTTLVELERQLRKENEKQKNELLSMEAEVCEKIG 933 Query: 1500 -FQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKT 1558 Q F+ + + FK + E+ L+N +++ ++ KD Sbjct: 934 CLQRFKEMAI-FKIAALQKVVDNSVSLSELELANKQYNELTAKY-------RDILQKDNM 985 Query: 1559 FIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMER 1618 + R S + + ++ Q+ ++LE +++L Q +Q T+L ++ M + ++ Sbjct: 986 LVQRTSNLEHLECENISLKEQVESINKELEITKEKLHTIEQAWEQETKLGNESSMDKAKK 1045 Query: 1619 Q--REDQEQLQEEIKRLN-RQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLC 1675 D + ++I L ++L +R ++ + E R L+++E Sbjct: 1046 SITNSDIVSISKKITMLEMKELNERQRAEHCQKMYEHLRTSLKQMEE------------- 1092 Query: 1676 CELRNSSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKIL 1735 RN +T+ + ++ Q ++ D + V + +R + + +++ Sbjct: 1093 ---RNFELETKFAELTKINLDAQKVEQMLRDELADSVSKAVSDADRQRILELEKNEMELK 1149 Query: 1736 LEVVKTTAAVEETIGRHVLGILDRSSKS-----QSSASLIWRSEAEASVKSCVHEEHTRV 1790 +EV K + I R + IL+ +S +S + +A++ KS + + H Sbjct: 1150 VEVSKLREISD--IARRQVEILNAQQQSRDKEVESLRMQLLDYQAQSDEKSLIAKLHQHN 1207 Query: 1791 TDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRL 1850 + + + + K+ L Q+L E E+ + Sbjct: 1208 VSLQLSEATALGKLESITSKLQKMEAYNLRLEQKL-----------DEKEQALYYARLEG 1256 Query: 1851 QAAVEKLLEAISETSSQLEHA-KVTQTELMRESFRQKQEATESLKCQEELRERLHEESRA 1909 + + L + I Q A + Q E ++ Q Q + LK +E++ E Sbjct: 1257 RNRAKHLRQTIQSLRRQFSGALPLAQQEKFSKTMIQLQN--DKLKIMQEMKNSQQEHRNM 1314 Query: 1910 RE---QLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQ 1966 ++ ++L E +I D K Q+++ +++EL ++ Sbjct: 1315 ENKTLEMELKLKGLEELISTLKDTKGA----------------QKVINWHMKIEELRLQE 1358 Query: 1967 QQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKAL 2026 ++ E L + KE +K ++ E E+ + E Q K ++ Q Sbjct: 1359 LKLNRE---LVKDKEEIK-----YLNNIISEYERTISSLEEEIVQQNKFHEERQMAWDQR 1410 Query: 2027 EIDVEEQVSRFIELEQEKNTELMDLRQQNQALE--KQLEKMRKFLDEQAIDREHERDVFQ 2084 E+D+E Q+ F RQQN+ L ++ E+ + + ++ ++ ++ Sbjct: 1411 EVDLERQLDIFD-------------RQQNEILNAAQKFEEATGSIPDPSLPLPNQLEI-- 1455 Query: 2085 QEIQKLEQQLKVVPRFQPISEHQTREV-EQLANHLKEKTDK---CSELLLSKEQLQRDIQ 2140 ++K+++ ++++ +TR + L LKEK + +LS++++ +++ Sbjct: 1456 -ALRKIKENIRIIL--------ETRATCKSLEEKLKEKESALRLAEQNILSRDKVINELR 1506 Query: 2141 ERNEEIEKLEFRVRELEQALLVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNL 2200 R + E + EL + + H + + +++ +L + + + + ++ L Sbjct: 1507 LRLPATAEREKLIAELGRKEMEPKSHHTLKIAHQTIANMQARLNQKEEVLKKYQRL---L 1563 Query: 2201 EEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQE-----------NKLFKDD 2249 E+ E+ RE ++ E++ LH +LE+Q S + ++ + NK F Sbjct: 1564 EKAREEQREIVKKHEEDLHILHHRLELQADSSLNKFKQTAWDLMKQSPTPVPTNKHFIRL 1623 Query: 2250 MEKLGLAIKESDAMSTQDQHVLFGKFAQIIQ--EKEVEIDQLN-EQVTKLQQQLKITTDN 2306 E ++ D++S+ L K ++ Q E++ EI +L ++ ++ QL+ ++ Sbjct: 1624 AEMEQTVAEQDDSLSS-----LLVKLKKVSQDLERQREITELKVKEFENIKLQLQENHED 1678 Query: 2307 KV------IEEKNELIRDLETQIECLMSDQECVK-----------RN-----------RE 2338 +V +E+ L+ + + +CL S+ + K RN +E Sbjct: 1679 EVKKVKAEVEDLKYLLDQSQKESQCLKSELQAQKEANSRAPTTTMRNLVERLKSQLALKE 1738 Query: 2339 EEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETAN 2398 ++ + L+ + +L+ E+ ++ ++A S E +++ +D E L+ QVE N Sbjct: 1739 KQQKALSRALLELRAEMTAAAEERIISATSQKEAHLNVQQIVDRHTRE---LKTQVEDLN 1795 Query: 2399 EEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELE 2458 E + +K LK + + N LT L L E + +K N + + + ++ EL Sbjct: 1796 ENLLKLKEALKTSKNRENSLTDNLNDLNNELQKKQKAY----NKILREKEEIDQENDEL- 1850 Query: 2459 VVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQ 2518 + +K L + K +N + I L+ ++ +LE+ + K E+ + K+ + Sbjct: 1851 ----KRQIKRLTSGLQGKPLTDNKQSLIEELQRKVKKLENQLEGKVEEVDLKPMKEKNAK 1906 Query: 2519 EQ--GQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQE-YAKFCQDNQTISSEPER 2575 E+ E + Q KI ++ ++EK QL +++ +AK ++ T+ + + Sbjct: 1907 EELIRWEEGKKWQAKIEGIRNKLKEKEGEVFTLTKQLNTLKDLFAKADKEKLTLQRKLKT 1966 Query: 2576 T--NIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEK-- 2631 T + + +R E ++ L R +LE+ ++ M L ++ V + + ++ + Sbjct: 1967 TGMTVDQVLGIRALESEKELEELKKRNLDLENDILYMRAHQALPRDSV-VEDLHLQNRYL 2025 Query: 2632 EKKLLELQKL-------------LEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESG 2678 ++KL L+K +E ++ QRE+E ++ E LK ++E N E Sbjct: 2026 QEKLHALEKQFSKDTYSKPSISGIESDDHCQREQELQK-----ENLKLSSE----NIELK 2076 Query: 2679 FFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDH------L 2732 F +LE + K ++ KE E L++E +Q+ L VR + Sbjct: 2077 F--QLEQANKDLPRLKNQVRDLKEMCEFLKKE-------KAEVQRKLGHVRGSGRSGKTI 2127 Query: 2733 AEAKEKLSILEKEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVK 2792 E ++ + +++K E +E+++ + + I S+ +A+ K+ + + L Sbjct: 2128 PELEKTIGLMKKVVEKVQRENEQ--LKKASGILTSEKMANIEQENEKLKAELEK---LKA 2182 Query: 2793 NAGIQINLQSECSSEEVTEIISQFTEKIEK--MQELHAAEILDMESRHI 2839 + G Q+++ E ++ +II++ E++ K +E AAE L + ++ Sbjct: 2183 HLGHQLSMHYESKTKGTEKIIAE-NERLRKELKKETDAAEKLRIAKNNL 2230 Score = 173 bits (438), Expect = 3e-42 Identities = 450/2335 (19%), Positives = 936/2335 (40%), Gaps = 381/2335 (16%) Query: 1584 EEQLEDMRQELVRQYQEHQQA-----TELLR------QAHMRQMERQREDQEQLQEEIKR 1632 E QL+ +L + + QQ+ T LR + + Q +R+ ED E+ E+ K+ Sbjct: 84 ENQLKTKVMKLENELEMAQQSAGGRDTRFLRNEICQLEKQLEQKDRELEDMEKELEKEKK 143 Query: 1633 LNRQLAQRS-SIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNEN 1691 +N QLA R+ +NEN RE L++ E+LC Q+ + Sbjct: 144 VNEQLALRNEEAENENSKLRRENKRLKK----------KNEQLC----------QDIIDY 183 Query: 1692 QGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGR 1751 Q +++ Q KE L R+ ED S+ R L K N L++ L E+ T A E+ Sbjct: 184 QKQIDSQ--KETLLSRRGED------SDYRSQLSKKNYELIQYLDEIQTLTEANEKI--- 232 Query: 1752 HVLGILDRSSKSQSSASLIWRSEAEASVKSCVHE------------EHTRVTDESIPSYS 1799 V R + +S + ++ +K+ VH+ +H ++ + + Sbjct: 233 EVQNQEMRKNLEESVQEMEKMTDEYNRMKAIVHQTDNVIDQLKKENDHYQLQVQELTDLL 292 Query: 1800 GSDMPRND---------INMW----SKVTEEGTELSQRL--VRSGFAGTEIDPENEELML 1844 S +D + W S +E E Q L +R ++D + +M Sbjct: 293 KSKNEEDDPIMVAVNAKVEEWKLILSSKDDEIIEYQQMLHNLREKLKNAQLDADKSNVMA 352 Query: 1845 ---NISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEAT----------- 1890 I R + ++ L E + + + ++E +L E R K +T Sbjct: 353 LQQGIQER-DSQIKMLTEQVEQYTKEMEKNTCIIEDLKNELQRNKGASTLSQQTHMKIQS 411 Query: 1891 ------ESLKCQEELRERLHEESRAREQLAVELSK--------AEGVIDGYADEKT---- 1932 E K E E ++R +++ VE K G+ D + K Sbjct: 412 TLDILKEKTKEAERTAELAEADAREKDKELVEALKRLKDYESGVYGLEDAVVEIKNCKNQ 471 Query: 1933 --LFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELL-----SRQKEAMKA 1985 + +R+I+ T I++LE ++ S+ L E EA ++++ E + + R + +K Sbjct: 472 IKIRDREIEILTKEINKLELKI---SDFLDENEALRERVGLEPKTMIDLTEFRNSKHLKQ 528 Query: 1986 EAGPVEQQ-LLQETEKLMKEKLEVQCQAEKVRDDLQKQ-----VKALEIDVEEQVSRFIE 2039 + E Q LL+E E L +E+L+++ + ++ + K+ + ++++ E +S+ Sbjct: 529 QQYRAENQILLKEIESLEEERLDLKKKIRQMAQERGKRSATSGLTTEDLNLTENISQGDR 588 Query: 2040 LEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPR 2099 + E+ +L+ L+ ++A K +FL + I++E + + + I K + +LK + Sbjct: 589 I-SERKLDLLSLKNMSEAQSK-----NEFLSRELIEKERDLERSRTVIAKFQNKLKELVE 642 Query: 2100 FQPISEHQTREVEQLANHLKEKTD----KCSELLLSKEQLQRDIQERNEE---------- 2145 E +E+ Q +++ D + S ++ S E+L I+ +N E Sbjct: 643 ENKQLEEGMKEILQAIKEMQKDPDVKGGETSLIIPSLERLVNAIESKNAEGIFDASLHLK 702 Query: 2146 --IEKLEFRVRELEQALLVEDRK---HFGAVEAKPELSLEVQLQAERDAIDRKE------ 2194 +++L R EL Q L E RK ++ AK L ++ L+ E + + E Sbjct: 703 AQVDQLTGRNEELRQELR-ESRKEAINYSQQLAKANLKID-HLEKETSLLRQSEGSNVVF 760 Query: 2195 ----------------------------KEITNLEEQLEQFREELENKNEEVQQLHMQLE 2226 +E+ N E++L+ + LE+ N + + Q Sbjct: 761 KGIDLPDGIAPSSASIINSQNEYLIHLLQELENKEKKLKNLEDSLEDYNRKFAVIRHQQS 820 Query: 2227 IQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEI 2286 + KE + + + E+K K++ KL +++ DA+ ++ + L E + + Sbjct: 821 LLYKEYLSEKETWKTESKTIKEEKRKLEDQVQQ-DAIKVKEYNNLLNALQMDSDEMKKIL 879 Query: 2287 DQLNEQVTKLQQQLK--ITTDNKVIEEKNELIRDLETQIECLMSDQE-------CVKRNR 2337 + + ++T LQ K I ++E + +L ++ E Q L+S + C++R + Sbjct: 880 AENSRKITVLQVNEKSLIRQYTTLVELERQLRKENEKQKNELLSMEAEVCEKIGCLQRFK 939 Query: 2338 E-------------------EEIEQLNEVIEKLQQELANIGQKTSMNAH----------- 2367 E E+E N+ +L + +I QK +M Sbjct: 940 EMAIFKIAALQKVVDNSVSLSELELANKQYNELTAKYRDILQKDNMLVQRTSNLEHLECE 999 Query: 2368 --SLSEEADSLKHQLDVVIAEKL-----ALEQQVETANEEMTFMKNVLKETNFKMNQLTQ 2420 SL E+ +S+ +L++ EKL A EQ+ + NE + K TN + +++ Sbjct: 1000 NISLKEQVESINKELEIT-KEKLHTIEQAWEQETKLGNES-SMDKAKKSITNSDIVSISK 1057 Query: 2421 ELFSLK----RERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQ---- 2472 ++ L+ ER+ E Q + E+ + ++ + + ELE E +L+ Q Sbjct: 1058 KITMLEMKELNERQRAEHCQKMYEH-LRTSLKQMEERNFELETKFAELTKINLDAQKVEQ 1116 Query: 2473 --------TYFKSFEENGKGSIINLETRLLQLESTVS--AKDLELTQCYKQIKDMQEQGQ 2522 + K+ + + I+ LE ++L+ VS + ++ + +I + Q+Q + Sbjct: 1117 MLRDELADSVSKAVSDADRQRILELEKNEMELKVEVSKLREISDIARRQVEILNAQQQSR 1176 Query: 2523 -FETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNL 2581 E E L+ ++++ Q +EK A + Q + A ++I+S+ ++ NL Sbjct: 1177 DKEVESLRMQLLDYQAQSDEKSLIAKLHQHNVSLQLSEATALGKLESITSKLQKMEAYNL 1236 Query: 2582 NQLREDELGSDISALTLRISELESQVVEMHTSL---------ILEKEQVEIAEKNVLEKE 2632 E +L AL E ++ + ++ L Q E K +++ + Sbjct: 1237 R--LEQKLDEKEQALYYARLEGRNRAKHLRQTIQSLRRQFSGALPLAQQEKFSKTMIQLQ 1294 Query: 2633 KKLLELQKLLEGNEKKQREKEKKRSPQDV------EVLKTTTELFHSNEESGFFNELEAL 2686 L++ + ++ ++++ R E K ++ E++ T + + + + ++E L Sbjct: 1295 NDKLKIMQEMKNSQQEHRNMENKTLEMELKLKGLEELISTLKDTKGAQKVINWHMKIEEL 1354 Query: 2687 RAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKED 2746 R + + EL KE+ + L + E ++SL++++ Q E + D Sbjct: 1355 RLQELKLNRELVKDKEEIKYLNNIISEYERTISSLEEEIVQQNKFHEERQMAW------D 1408 Query: 2747 ETEVQESKKACMFE-------PLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQIN 2799 + EV ++ +F+ K ++ S D +L + + + +K I+I Sbjct: 1409 QREVDLERQLDIFDRQQNEILNAAQKFEEATGSIPDPSLPLPNQLEIALRKIKE-NIRII 1467 Query: 2800 LQSECSSEEVTEIISQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLLKE- 2858 L++ + + + E + + + ++ + + + T +RE +A KE Sbjct: 1468 LETRATCKSLEEKLKEKESALRLAEQNILSRDKVINELRLRLPATAEREKLIAELGRKEM 1527 Query: 2859 ---ECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDI 2915 TLK Q + + + + YQ + + + I H + I Sbjct: 1528 EPKSHHTLKIAHQTIANMQARLNQKEEVLKKYQR----LLEKAREEQREIVKKHEEDLHI 1583 Query: 2916 ASEGRGEESESATDSFPKKIKGLLR-----AVHNEGMQVLSLTESPYSDGEDH------S 2964 +++S+ + F + L++ N+ L+ E ++ +D Sbjct: 1584 LHHRLELQADSSLNKFKQTAWDLMKQSPTPVPTNKHFIRLAEMEQTVAEQDDSLSSLLVK 1643 Query: 2965 IQQVSEPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQ 3024 +++VS+ +R+ + +++ ++Q E EV E + LL Q Sbjct: 1644 LKKVSQDLERQREITELKVKEFENIKLQLQENHEDEVKKVKAEVEDL-----KYLLDQSQ 1698 Query: 3025 VFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLS 3084 +E L + + + A + N +E R++ Q A E QKA R+LL Sbjct: 1699 ---KESQCLKSELQAQKEANSRAPTTTMRNLVE-RLKSQ----LALKEKQQKALSRALLE 1750 Query: 3085 EIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQE 3144 + A R I+ ++E+ Q++++ + + E++ ++ + + +L+E Sbjct: 1751 LRAEMTAAAEERIISATSQKEAHLNVQQIVDRHTR-------ELKTQVEDLNENLLKLKE 1803 Query: 3145 QLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLAS 3204 L + K L L EL+ KA +K L+E E E + ++ L L Sbjct: 1804 ALKTSKNRENSLTDNLNDLNNELQKKQKAYNKILREKEEIDQENDELKRQIKRLTSGLQG 1863 Query: 3205 EQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNE 3264 + + Q +E+ + K+ + E + + ++E++ L+ K++N + L+ ++ + + Sbjct: 1864 KPLTDNK-QSLIEELQRKVKKLENQLEGKVEEV--DLKPMKEKNAKEELIRWEEGK---K 1917 Query: 3265 SQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRER-ELHAQLQSSDG 3323 Q KIE R +L E++G L L + ++++ + D+E+ L +L++ Sbjct: 1918 WQAKIEGIR----NKLKEKEGEVFTLTKQLNT----LKDLFAKADKEKLTLQRKLKT--- 1966 Query: 3324 TGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTL 3383 TG + + L E +K+LEE R ++L N+ + ++ Q + +D V L Sbjct: 1967 TGMTVDQVLGIRAL-ESEKELEELKKRNLDLEND-----ILYMRAHQALPRDSVVEDLHL 2020 Query: 3384 QTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLD-LEGQRLQGIMQEFQKQELER 3442 Q LQ K+ L++Q + + +E QE QK+ L+ Sbjct: 2021 QNRY------------LQEKLHALEKQFSKDTYSKPSISGIESDDHCQREQELQKENLKL 2068 Query: 3443 EEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNH 3502 + + + N+ R +N V K E + A++ G G Sbjct: 2069 SSENIELKFQLEQANKDL------PRLKNQVRDLKEMCEFLKKEKAEVQRKLGHVRGSGR 2122 Query: 3503 ELEMIRQKLQCVASKLQVLPQKASERLQFETAD----DEDFIWVQENIDEIILQLQKLTG 3558 + I + + + +V+ + E Q + A E +++ +++ +L+KL Sbjct: 2123 SGKTIPELEKTIGLMKKVVEKVQRENEQLKKASGILTSEKMANIEQENEKLKAELEKLKA 2182 Query: 3559 QQGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLR----NMVMKLEEQIRW 3614 G + S+ S + G TE+++ +N L + + T+ LR N+ + E+ Sbjct: 2183 HLGHQLSMHYESKTKG--TEKIIAENERLRKELKKETDAAEKLRIAKNNLEILNEKMTVQ 2240 Query: 3615 YRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKLT--LQKSLKRAEAEVYK 3667 +TG +F+ + G +E ++ + W +T + LK E ++ K Sbjct: 2241 LEETG----KRLQFAESRGPQLE---GADSKSWKSIVVTRMYETKLKELETDIAK 2288 Score = 166 bits (420), Expect = 4e-40 Identities = 422/2115 (19%), Positives = 858/2115 (40%), Gaps = 389/2115 (18%) Query: 1838 ENEEL---MLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMR--ESFRQKQEATES 1892 +NE+L +++ ++ + E LL E S EL++ + + EA E Sbjct: 172 KNEQLCQDIIDYQKQIDSQKETLLSRRGEDSDYRSQLSKKNYELIQYLDEIQTLTEANEK 231 Query: 1893 LKCQ-EELRERLHEESRAREQLAVELSK-------AEGVIDGYADEKTLFERQIQEKTDI 1944 ++ Q +E+R+ L E + E++ E ++ + VID E ++ Q+QE TD+ Sbjct: 232 IEVQNQEMRKNLEESVQEMEKMTDEYNRMKAIVHQTDNVIDQLKKENDHYQLQVQELTDL 291 Query: 1945 ID---------------RLEQELLCASNRLQELEAEQQQIQEERELLSR-QKEAMKAEAG 1988 + ++E+ L S++ E+ QQ + RE L Q +A K+ Sbjct: 292 LKSKNEEDDPIMVAVNAKVEEWKLILSSKDDEIIEYQQMLHNLREKLKNAQLDADKSNVM 351 Query: 1989 PVEQ----------QLLQETEKLMKEKLEVQCQAEKVRDDLQ--KQVKALEIDVEEQVSR 2036 ++Q L ++ E+ KE + C E ++++LQ K L ++ Sbjct: 352 ALQQGIQERDSQIKMLTEQVEQYTKEMEKNTCIIEDLKNELQRNKGASTLSQQTHMKIQS 411 Query: 2037 FIELEQEKNTEL--------MDLRQQNQALEKQLEKMRKF------LDEQAID------- 2075 +++ +EK E D R++++ L + L++++ + L++ ++ Sbjct: 412 TLDILKEKTKEAERTAELAEADAREKDKELVEALKRLKDYESGVYGLEDAVVEIKNCKNQ 471 Query: 2076 ---REHERDVFQQEIQKLEQQLK-VVPRFQPISEHQTREVEQL--------ANHLKEKTD 2123 R+ E ++ +EI KLE ++ + + + E E + + + HLK++ Sbjct: 472 IKIRDREIEILTKEINKLELKISDFLDENEALRERVGLEPKTMIDLTEFRNSKHLKQQQY 531 Query: 2124 KCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVEDRKHFGAVEAKPELSLEVQL 2183 + +L KE I+ EE L+ ++R++ Q ++ + +L+L + Sbjct: 532 RAENQILLKE-----IESLEEERLDLKKKIRQMAQE---RGKRSATSGLTTEDLNLTENI 583 Query: 2184 QAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTT-------RL 2236 ++ D I ++ ++ +L+ E ++KNE + + ++ E + S T +L Sbjct: 584 -SQGDRISERKLDLLSLKNM-----SEAQSKNEFLSRELIEKERDLERSRTVIAKFQNKL 637 Query: 2237 QELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKE------------- 2283 +EL +ENK ++ M+++ AIKE +D V G+ + II E Sbjct: 638 KELVEENKQLEEGMKEILQAIKEMQ----KDPDVKGGETSLIIPSLERLVNAIESKNAEG 693 Query: 2284 ---------VEIDQLNEQVTKLQQQLKITTDNKV-----IEEKNELIRDLETQIECLMSD 2329 ++DQL + +L+Q+L+ + + + + N I LE + L Sbjct: 694 IFDASLHLKAQVDQLTGRNEELRQELRESRKEAINYSQQLAKANLKIDHLEKETSLLRQS 753 Query: 2330 Q------------ECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSE---EAD 2374 + + + + I NE + L QEL N +K SL + + Sbjct: 754 EGSNVVFKGIDLPDGIAPSSASIINSQNEYLIHLLQELENKEKKLKNLEDSLEDYNRKFA 813 Query: 2375 SLKHQLDVV----IAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERE 2430 ++HQ ++ ++EK + + +T EE +++ +++ K+ + L +L+ + + Sbjct: 814 VIRHQQSLLYKEYLSEKETWKTESKTIKEEKRKLEDQVQQDAIKVKEYNNLLNALQMDSD 873 Query: 2431 SVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLE 2490 ++KI + ENS + + ++ E ++ L LE Q + E K ++++E Sbjct: 874 EMKKI--LAENSRKITVLQVN----EKSLIRQYTTLVELERQ--LRKENEKQKNELLSME 925 Query: 2491 TRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAA---L 2547 A+ E C ++ K EM KI LQK+V+ V+ + L Sbjct: 926 -----------AEVCEKIGCLQRFK----------EMAIFKIAALQKVVDNSVSLSELEL 964 Query: 2548 VSQIQLEAVQEYAKFCQ-DNQTI--SSEPERTNIQNLNQLREDE-LGSDISALTLRISEL 2603 ++ E +Y Q DN + +S E +N++ + E + ++ ++ + Sbjct: 965 ANKQYNELTAKYRDILQKDNMLVQRTSNLEHLECENISLKEQVESINKELEITKEKLHTI 1024 Query: 2604 ESQVVEMHTSL----ILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQ 2659 E Q E T L ++K + I +++ KK+ L+ + E NE+++ E +K Sbjct: 1025 E-QAWEQETKLGNESSMDKAKKSITNSDIVSISKKITMLE-MKELNERQRAEHCQKM--- 1079 Query: 2660 DVEVLKTTTELFHSNE---ESGFFN----ELEALRAESVATKAELASYKEKA--EKLQEE 2710 E L+T+ + E+ F L+A + E + + ELA KA + ++ Sbjct: 1080 -YEHLRTSLKQMEERNFELETKFAELTKINLDAQKVEQML-RDELADSVSKAVSDADRQR 1137 Query: 2711 LLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLSKSI 2770 +L E N L+ ++S++R+ A+ ++ IL + ++ +E E L ++L Sbjct: 1138 ILELEKNEMELKVEVSKLREISDIARRQVEILNAQQQSRDKE------VESLRMQLLDYQ 1191 Query: 2771 ASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTEIIS-QFTEKI-EKMQELHA 2828 A + +L + + A L+S S + E + + +K+ EK Q L+ Sbjct: 1192 AQSDEKSLIAKLHQHNVSLQLSEATALGKLESITSKLQKMEAYNLRLEQKLDEKEQALYY 1251 Query: 2829 AEILDME-SRHISET-ETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDA 2886 A + ++H+ +T ++L+R+ A+ L ++E + K +IQ L++ + + E+ +S Sbjct: 1252 ARLEGRNRAKHLRQTIQSLRRQFSGALPLAQQEKFS-KTMIQ-LQNDKLKIMQEMKNSQQ 1309 Query: 2887 YQTR----------------EICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESESATDS 2930 E+ S+ + Q + H + ++ + E D Sbjct: 1310 EHRNMENKTLEMELKLKGLEELISTLKDTKGAQKVINWHMKIEELRLQELKLNRELVKDK 1369 Query: 2931 FPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINTISSLKDLI 2990 ++IK L + + SL E + H +Q++ W + Sbjct: 1370 --EEIKYLNNIISEYERTISSLEEEIVQQNKFHEERQMA--WDQR--------------- 1410 Query: 2991 TKMQLQREAEVYDSSQSH-----ESFSDWRG-----------ELLLALQQVFLEERSVLL 3034 ++ L+R+ +++D Q+ + F + G +L +AL+++ R +L Sbjct: 1411 -EVDLERQLDIFDRQQNEILNAAQKFEEATGSIPDPSLPLPNQLEIALRKIKENIRIILE 1469 Query: 3035 AAFRTELTALGTTDAVGLLNCLEQRIQEQG-VEYQAAMECLQKADRRSLLSEI------- 3086 + + L EQ I + V + + A+R L++E+ Sbjct: 1470 TRATCKSLEEKLKEKESALRLAEQNILSRDKVINELRLRLPATAEREKLIAELGRKEMEP 1529 Query: 3087 ------QALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQS-------------QMLE 3127 + H + + L +++E K Q LLE ++++ LE Sbjct: 1530 KSHHTLKIAHQTIANMQARLNQKEEVLKKYQRLLEKAREEQREIVKKHEEDLHILHHRLE 1589 Query: 3128 MQVE--LSSMKDRATELQEQ-------------LSSEKMVVAE-------LKSELAQTKL 3165 +Q + L+ K A +L +Q L+ + VAE L +L + Sbjct: 1590 LQADSSLNKFKQTAWDLMKQSPTPVPTNKHFIRLAEMEQTVAEQDDSLSSLLVKLKKVSQ 1649 Query: 3166 ELETTLKAQHKHLKELEAFRL--------EVKDKTDEVHLLNDTLASEQKKSRELQWALE 3217 +LE + +KE E +L EVK EV L L QK+S+ L+ L+ Sbjct: 1650 DLERQREITELKVKEFENIKLQLQENHEDEVKKVKAEVEDLKYLLDQSQKESQCLKSELQ 1709 Query: 3218 KEKAKLGRSEERDKEEL-EDLKFSLE-SQKQRNLQLNLLLEQQKQLLNESQQKIESQRML 3275 +K R+ L E LK L +KQ+ LLE + ++ ++++I S Sbjct: 1710 AQKEANSRAPTTTMRNLVERLKSQLALKEKQQKALSRALLELRAEMTAAAEERIISATSQ 1769 Query: 3276 YDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSED 3335 +A L+ +Q + + L K ++ +++ L + +E L++S S D Sbjct: 1770 KEAHLNVQQIVDRHTREL----KTQVEDLNENLLKLKE---ALKTSKNRENS-----LTD 1817 Query: 3336 LLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEG-Q 3394 L +L +L++K ++L E E+ ++ E RQ+ R T + + T+ Q Sbjct: 1818 NLNDLNNELQKKQKAYNKILREKEEI------DQENDELKRQIKRLTSGLQGKPLTDNKQ 1871 Query: 3395 KKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELEREEKRESRRI--L 3452 + ELQ KV+ L+ QLE K ++V DL+ + + +E + E E K+ +I + Sbjct: 1872 SLIEELQRKVKKLENQLEGKVEEV---DLKPMKEKNAKEELIRWE---EGKKWQAKIEGI 1925 Query: 3453 YQNLNEPTTWSLTSDRTRNWVL-------QQKIEGETKESNYAKLIEMNGGGTGCNHELE 3505 L E T + N + ++K+ + K ++ G E E Sbjct: 1926 RNKLKEKEGEVFTLTKQLNTLKDLFAKADKEKLTLQRKLKTTGMTVDQVLGIRALESEKE 1985 Query: 3506 MIRQKLQCVASKLQVLPQKASERLQFETADDEDFI---WVQENIDEIILQLQKLTGQQGE 3562 + K + + + +L +A + L ++ ++ + ++QE + + Q K T Sbjct: 1986 LEELKKRNLDLENDILYMRAHQALPRDSVVEDLHLQNRYLQEKLHALEKQFSKDT---YS 2042 Query: 3563 EPSL--VSPSTSCGSLTE------RLLRQNAELTGHISQLTEEKNDLRNMVMKLEEQIRW 3614 +PS+ + C E +L +N EL + Q ++ L+N V L+E + Sbjct: 2043 KPSISGIESDDHCQREQELQKENLKLSSENIELKFQLEQANKDLPRLKNQVRDLKEMCEF 2102 Query: 3615 YRQ------------TGAGRDNSSRFSLNGGAN-----IEAIIASEKEVWNREKLTLQKS 3657 ++ G+GR + L +E + +++ + + Sbjct: 2103 LKKEKAEVQRKLGHVRGSGRSGKTIPELEKTIGLMKKVVEKVQRENEQLKKASGILTSEK 2162 Query: 3658 LKRAEAEVYKLKAEL 3672 + E E KLKAEL Sbjct: 2163 MANIEQENEKLKAEL 2177 Score = 166 bits (419), Expect = 5e-40 Identities = 476/2436 (19%), Positives = 972/2436 (39%), Gaps = 396/2436 (16%) Query: 1331 LEKTKLEEQVQELESLISSLQQQLKETEQ----NYEAE-----IHCLQKRLQAVSESTVP 1381 LEK +LE++ +ELE + L+++ K EQ N EAE + KRL+ +E Sbjct: 120 LEK-QLEQKDRELEDMEKELEKEKKVNEQLALRNEEAENENSKLRRENKRLKKKNEQLCQ 178 Query: 1382 PSLPVDSVVITESDA------QRTMYPGSCVKKNIDGTIEFSGEFGVKEETNI-VKLLEK 1434 + + ++ + + + Y KKN + I++ E E N +++ + Sbjct: 179 DIIDYQKQIDSQKETLLSRRGEDSDYRSQLSKKNYE-LIQYLDEIQTLTEANEKIEVQNQ 237 Query: 1435 QYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMKLS 1494 + ++ LEE V ++ ++ T + A+ Q + +++K Sbjct: 238 EMRKNLEESVQEM--------------------EKMTDEYNRMKAIVHQTDNVIDQLKKE 277 Query: 1495 QDQIGFQTFETVDV--KFKEEFKPLSKELGEHGKE--ILLSNSDPHDIPESKDCVLTISE 1550 D Q E D+ EE P+ + +E ++LS+ D +I E + + + E Sbjct: 278 NDHYQLQVQELTDLLKSKNEEDDPIMVAVNAKVEEWKLILSSKDD-EIIEYQQMLHNLRE 336 Query: 1551 EMFS------KDKTFIVRQSIHDEISVSSM------DASRQLMLNEEQLEDMRQELVRQY 1598 ++ + K ++Q I + S M ++++ N +ED++ EL Sbjct: 337 KLKNAQLDADKSNVMALQQGIQERDSQIKMLTEQVEQYTKEMEKNTCIIEDLKNEL---- 392 Query: 1599 QEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLE 1658 Q ++ A+ L +Q HM+ + + L+E+ K A+R++ E E+++ L+E Sbjct: 393 QRNKGASTLSQQTHMKI----QSTLDILKEKTKE-----AERTAELAEADAREKDKELVE 443 Query: 1659 ELEALK--QLSLAGREKLCCELRNSSTQTQNGNE---------NQGEVEEQTF-KEKELD 1706 L+ LK + + G E E++N Q + + N+ E++ F E E Sbjct: 444 ALKRLKDYESGVYGLEDAVVEIKNCKNQIKIRDREIEILTKEINKLELKISDFLDENEAL 503 Query: 1707 RKPEDVPPEIL------SNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRS 1760 R+ + P+ + N ++ Q+ +ILL+ +++ + + + + Sbjct: 504 RERVGLEPKTMIDLTEFRNSKHLKQQQYRAENQILLKEIESLEEERLDLKKKIRQMAQER 563 Query: 1761 SKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTE 1820 K +++ L + + ++ + + R+++ + S +M ++ E E Sbjct: 564 GKRSATSGL---TTEDLNLTENI-SQGDRISERKLDLLSLKNMSEAQSKN-EFLSRELIE 618 Query: 1821 LSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMR 1880 + L RS + + +EL+ + +L+ ++++L+AI E + K +T L+ Sbjct: 619 KERDLERSRTVIAKFQNKLKELVEE-NKQLEEGMKEILQAIKEMQKDPD-VKGGETSLII 676 Query: 1881 ESFRQKQEATES------------LKCQ--------EELRERLHEESRAREQLAVELSKA 1920 S + A ES LK Q EELR+ L E + + +L+KA Sbjct: 677 PSLERLVNAIESKNAEGIFDASLHLKAQVDQLTGRNEELRQELRESRKEAINYSQQLAKA 736 Query: 1921 EGVIDGYADEKTLFERQ----------------IQEKTDIIDRLEQELLCASNRLQELEA 1964 ID E +L + II+ + L+ L+ E Sbjct: 737 NLKIDHLEKETSLLRQSEGSNVVFKGIDLPDGIAPSSASIINSQNEYLIHLLQELENKEK 796 Query: 1965 EQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQ-- 2022 + + +++ E +R+ ++ + + ++ L E E E ++ + K+ D +Q+ Sbjct: 797 KLKNLEDSLEDYNRKFAVIRHQQSLLYKEYLSEKETWKTESKTIKEEKRKLEDQVQQDAI 856 Query: 2023 --------VKALEIDVEE------QVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKF 2068 + AL++D +E + SR I + Q L+ LE+QL K + Sbjct: 857 KVKEYNNLLNALQMDSDEMKKILAENSRKITVLQVNEKSLIRQYTTLVELERQLRKENEK 916 Query: 2069 LDEQAIDREHE--------RDVFQQEIQKLEQQLKVVPRFQPISEHQT------------ 2108 + + E E + + I K+ KVV +SE + Sbjct: 917 QKNELLSMEAEVCEKIGCLQRFKEMAIFKIAALQKVVDNSVSLSELELANKQYNELTAKY 976 Query: 2109 REVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVEDRKHF 2168 R++ Q N L ++T L L+ ++ N+E+E + ++ +EQA E + Sbjct: 977 RDILQKDNMLVQRTSNLEHLECENISLKEQVESINKELEITKEKLHTIEQAWEQETKLGN 1036 Query: 2169 GAVEAKPELSLE----VQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQ 2224 + K + S+ V + + ++ KE E ++ E L +++++ + + Sbjct: 1037 ESSMDKAKKSITNSDIVSISKKITMLEMKELNERQRAEHCQKMYEHLRTSLKQMEERNFE 1096 Query: 2225 LEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEV 2284 LE + E T + ++ ++ +D+ LA S A+S D+ + + + E +V Sbjct: 1097 LETKFAELTKINLDAQKVEQMLRDE-----LADSVSKAVSDADRQRIL-ELEKNEMELKV 1150 Query: 2285 EIDQLNEQVTKLQQQLKIT-----TDNKVIEEKNELIRDLETQ------IECLMSDQECV 2333 E+ +L E ++Q++I + +K +E + D + Q I L + Sbjct: 1151 EVSKLREISDIARRQVEILNAQQQSRDKEVESLRMQLLDYQAQSDEKSLIAKLHQHNVSL 1210 Query: 2334 KRNREEEIEQLNEVIEKLQQ-ELANIGQKTSMN----------------AHSLSEEADSL 2376 + + + +L + KLQ+ E N+ + ++ A L + SL Sbjct: 1211 QLSEATALGKLESITSKLQKMEAYNLRLEQKLDEKEQALYYARLEGRNRAKHLRQTIQSL 1270 Query: 2377 KHQLDVVIA----------------EKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQ 2420 + Q + +KL + Q+++ + +E M+N E K+ L + Sbjct: 1271 RRQFSGALPLAQQEKFSKTMIQLQNDKLKIMQEMKNSQQEHRNMENKTLEMELKLKGL-E 1329 Query: 2421 ELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPEL-EVVLTEDALKSLENQTYFKSFE 2479 EL S ++ + +K+ + H+ ++ L E+ L + +K E Y + Sbjct: 1330 ELISTLKDTKGAQKVINW----------HMKIEELRLQELKLNRELVKDKEEIKYLNNII 1379 Query: 2480 ENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIV 2539 + +I +LE ++Q + + Q +++ ++ F+ + Q +I+N + Sbjct: 1380 SEYERTISSLEEEIVQQNKFHEERQMAWDQ--REVDLERQLDIFDRQ--QNEILNAAQKF 1435 Query: 2540 EEKVAAALVSQIQLEAVQEYA-KFCQDNQTISSEPERTNIQNLNQLREDE---------- 2588 EE + + L E A + ++N I E T +L+E E Sbjct: 1436 EEATGSIPDPSLPLPNQLEIALRKIKENIRIILETRATCKSLEEKLKEKESALRLAEQNI 1495 Query: 2589 LGSD--ISALTLRI---SELESQVVEM---------HTSLILEKEQVEIAEKNVLEKEKK 2634 L D I+ L LR+ +E E + E+ H +L + + + + + +KE+ Sbjct: 1496 LSRDKVINELRLRLPATAEREKLIAELGRKEMEPKSHHTLKIAHQTIANMQARLNQKEEV 1555 Query: 2635 LLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATK 2694 L + Q+LLE ++QRE KK +D+ +L EL + + F L +S T Sbjct: 1556 LKKYQRLLEKAREEQREIVKKHE-EDLHILHHRLELQADSSLNKFKQTAWDLMKQS-PTP 1613 Query: 2695 AELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDET---EVQ 2751 + + ++++ + ++ +++SL L +V L +E + KE E ++Q Sbjct: 1614 VPTNKHFIRLAEMEQTVAEQDDSLSSLLVKLKKVSQDLERQREITELKVKEFENIKLQLQ 1673 Query: 2752 ESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTE 2811 E+ + ++ K A D + S + Q L ++ Q E +S T Sbjct: 1674 ENHED--------EVKKVKAEVEDLKYLLDQSQKESQCLKS----ELQAQKEANSRAPTT 1721 Query: 2812 IISQFTEKI-------EKMQELHAAEILDM--------ESRHISETETLKREHYVAVQLL 2856 + E++ EK Q+ + +L++ E R IS T K H Q++ Sbjct: 1722 TMRNLVERLKSQLALKEKQQKALSRALLELRAEMTAAAEERIISATSQ-KEAHLNVQQIV 1780 Query: 2857 KEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIA 2916 LK ++ L L S + RE +D+ +D + I Sbjct: 1781 DRHTRELKTQVEDLNENLLKLKEALKTS---KNRENSLTDNLNDLNNELQKKQKAYNKIL 1837 Query: 2917 SEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGED--HSIQQVSEPWLE 2974 E EE + D ++IK L G+Q LT++ S E+ ++++ E LE Sbjct: 1838 REK--EEIDQENDELKRQIKRL-----TSGLQGKPLTDNKQSLIEELQRKVKKL-ENQLE 1889 Query: 2975 ERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESF----SDWRGEL------LLALQQ 3024 + ++ + +K+ K +L R E E + GE+ L L+ Sbjct: 1890 GKVEEVD-LKPMKEKNAKEELIRWEEGKKWQAKIEGIRNKLKEKEGEVFTLTKQLNTLKD 1948 Query: 3025 VFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQ-----------EQGVEYQAAMEC 3073 +F + L R T T D V + LE + E + Y A + Sbjct: 1949 LFAKADKEKLTLQRKLKTTGMTVDQVLGIRALESEKELEELKKRNLDLENDILYMRAHQA 2008 Query: 3074 LQK--------ADRRSLLSEIQALHAQMNGRKIT------------LKREQESEKPSQEL 3113 L + R L ++ AL Q + + +REQE +K + +L Sbjct: 2009 LPRDSVVEDLHLQNRYLQEKLHALEKQFSKDTYSKPSISGIESDDHCQREQELQKENLKL 2068 Query: 3114 LEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELA---------QTK 3164 NI+ K Q+ + +L +K++ +L+E K AE++ +L +T Sbjct: 2069 SSENIELK-FQLEQANKDLPRLKNQVRDLKEMCEFLKKEKAEVQRKLGHVRGSGRSGKTI 2127 Query: 3165 LELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLG 3224 ELE T+ K +++++ ++K + L ++ +A+ ++++ +L+ LEK KA LG Sbjct: 2128 PELEKTIGLMKKVVEKVQRENEQLKKASGI--LTSEKMANIEQENEKLKAELEKLKAHLG 2185 Query: 3225 R-------SEERDKEEL--EDLKFSLESQKQRNLQLNLLLEQQK-QLLNESQQKIESQRM 3274 S+ + E++ E+ + E +K+ + L + + ++LNE + ++ + Sbjct: 2186 HQLSMHYESKTKGTEKIIAENERLRKELKKETDAAEKLRIAKNNLEILNE-KMTVQLEET 2244 Query: 3275 LYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSE 3334 Q +E +G LE + + + M T +E E ++ T + + Sbjct: 2245 GKRLQFAESRGPQLEGADSKSWKSIVVTRMYETKLKELETDIAKKNQSITDLKQLVKEAT 2304 Query: 3335 DLLKELQKQLEEKHSRIVELLN-----ETEKYKLDSLQT----RQQMEKDRQ--VHRKTL 3383 + +++ K E+ +I L + ETE+ LQ Q++K++ +H+ Sbjct: 2305 EREQKVNKYNEDLEQQIKILKHVPEGAETEQGLKRELQVLRLANHQLDKEKAELIHQIEA 2364 Query: 3384 QTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELERE 3443 +Q +L+ K++DL+ QL+ DLE Q L+ +++ K+ELE Sbjct: 2365 NKDQSGAESTIPDADQLKEKIKDLETQLKMS-------DLEKQHLKEEIKKL-KKELENF 2416 Query: 3444 EKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIE 3479 + I E ++ + +N +L++K++ Sbjct: 2417 DPSFFEEI------EDLKYNYKEEVKKNILLEEKVK 2446 Score = 75.1 bits (183), Expect = 1e-12 Identities = 147/697 (21%), Positives = 293/697 (42%), Gaps = 91/697 (13%) Query: 3056 LEQRIQEQGV---EYQAAMECLQKADRRSLLSEIQALHAQMNGRKIT--LKREQESEKPS 3110 LE+ +QE EY + + D + + H Q+ +++T LK + E + P Sbjct: 243 LEESVQEMEKMTDEYNRMKAIVHQTDNVIDQLKKENDHYQLQVQELTDLLKSKNEEDDPI 302 Query: 3111 QELLEYNIQQ-------KQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQT 3163 + +++ K +++E Q L +++++ Q L ++K V L+ + + Sbjct: 303 MVAVNAKVEEWKLILSSKDDEIIEYQQMLHNLREKLKNAQ--LDADKSNVMALQQGIQER 360 Query: 3164 KLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALE--KEKA 3221 +++ + ++ KE+E ++D +E+ Q+ ++Q L+ KEK Sbjct: 361 DSQIKMLTEQVEQYTKEMEKNTCIIEDLKNELQRNKGASTLSQQTHMKIQSTLDILKEKT 420 Query: 3222 KLGR---------SEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQ 3272 K + E+DKE +E LK L+ + L + + K N Q KI + Sbjct: 421 KEAERTAELAEADAREKDKELVEALK-RLKDYESGVYGLEDAVVEIKNCKN--QIKIRDR 477 Query: 3273 RMLYDAQLSEEQGRNLELQV---LLESEKVRIR---EMSSTLDRERELHAQLQSSDGTGQ 3326 + ++ ++ LEL++ L E+E +R R E + +D + ++S Q Sbjct: 478 EI----EILTKEINKLELKISDFLDENEALRERVGLEPKTMIDL-----TEFRNSKHLKQ 528 Query: 3327 SRPPLPSEDLLKELQKQLEEK---HSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTL 3383 + ++ LLKE++ EE+ +I ++ E K S T + + + + Sbjct: 529 QQYRAENQILLKEIESLEEERLDLKKKIRQMAQERGKRSATSGLTTEDLNLTENISQGDR 588 Query: 3384 QTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELERE 3443 +E++ + K M E QSK E L R+L EK + + + + Q ++E ++ + E Sbjct: 589 ISERKLDLLSLKNMSEAQSKNEFLSRELIEKERDLERSRTVIAKFQNKLKELVEENKQLE 648 Query: 3444 E-KRESRRILYQNLNEP------TTWSLTS-DRTRNWVLQQKIEGETKESNYAKLIEMNG 3495 E +E + + + +P T+ + S +R N + + EG S + K Sbjct: 649 EGMKEILQAIKEMQKDPDVKGGETSLIIPSLERLVNAIESKNAEGIFDASLHLK--AQVD 706 Query: 3496 GGTGCNHELEMIRQKL-QCVASKLQVLPQKASERLQFETADDEDFIWVQENIDEIILQLQ 3554 TG N EL RQ+L + + Q A L+ + + E + Q ++ + Sbjct: 707 QLTGRNEEL---RQELRESRKEAINYSQQLAKANLKIDHLEKETSLLRQSEGSNVVFKGI 763 Query: 3555 KLTGQQGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKLEEQIRW 3614 L P ++PS++ + QN L + +L ++ L+N+ LE+ + Sbjct: 764 DL-------PDGIAPSSA-----SIINSQNEYLIHLLQELENKEKKLKNLEDSLED---Y 808 Query: 3615 YRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRAEAEVYKLKAELRN 3674 R+ R S + SEKE W E T+++ ++ E +V + +++ Sbjct: 809 NRKFAVIRHQQSL--------LYKEYLSEKETWKTESKTIKEEKRKLEDQVQQDAIKVKE 860 Query: 3675 -DSLLQTLSPDSEHVTLKRIYGKYLRAESFRKALIYQ 3710 ++LL L DS+ + K + AE+ RK + Q Sbjct: 861 YNNLLNALQMDSDEM-------KKILAENSRKITVLQ 890 Score = 50.1 bits (118), Expect = 4e-05 Identities = 76/388 (19%), Positives = 173/388 (44%), Gaps = 50/388 (12%) Query: 170 EIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDE-TMREF 228 E E+ R+L +R + G G + + E E I ++ ++ +Q ++ T + Sbjct: 2106 EKAEVQRKLGHVRGS-GRSG-KTIPELEKTIGLMKKVVEKVQRENEQLKKASGILTSEKM 2163 Query: 229 LELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQ 288 + ++++KL+ + ++L+A + S H + + ++I+ ++L ++ D Sbjct: 2164 ANIEQENEKLKAELEKLKAHLGHQLSMHYESKT---KGTEKIIAENERLRKELKKETDAA 2220 Query: 289 KKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEK----------------ETIIE 332 +K + L EK+ V E K+++ + Q + ET ++ Sbjct: 2221 EKLRIAKNNLEILNEKMTVQLEETGKRLQFAESRGPQLEGADSKSWKSIVVTRMYETKLK 2280 Query: 333 ELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSE 392 EL T I ++ + +LK + A + +EQ V K E ++++ + ++ + Sbjct: 2281 ELETDIAKKNQSITDLKQLVKEATE-----REQKVNKYNEDLEQQIKILKHVPEGAETEQ 2335 Query: 393 EIKQLMGTVEELQKRNHKDSQFETDIVQRME--------QETQRKLEQLRAELDEMYGQQ 444 +K+ ++ L+ NH+ + + +++ ++E + T +QL+ ++ ++ Q Sbjct: 2336 GLKR---ELQVLRLANHQLDKEKAELIHQIEANKDQSGAESTIPDADQLKEKIKDLETQL 2392 Query: 445 IVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQD 504 + +L +QH+ EE+K + K E+EN S+ + +K + NI L++ Sbjct: 2393 KMS---DLEKQHLK--EEIK-KLKKELENFDPSFFE---EIEDLKYNYKEEVKKNILLEE 2443 Query: 505 TNSQKEKLKEELGLILEEKCALQRQLED 532 + +KL E+LG+ L A + ED Sbjct: 2444 ---KVKKLSEQLGVELTSPVAASEEFED 2468 Score = 37.0 bits (84), Expect = 0.38 Identities = 40/158 (25%), Positives = 66/158 (41%), Gaps = 17/158 (10%) Query: 3535 DDEDFIWVQENIDEIILQLQKLTGQQ--GEEPSLVSPSTSCGSLTERLLRQNAELT-GHI 3591 D +D +E D +++ L K+ + E+ V ++ Q EL + Sbjct: 14 DPDDLPRQEELADNLLISLSKVEVNELKSEKQENVIHLFRITQSLMKMKAQEVELALEEV 73 Query: 3592 SQLTEEK----NDLRNMVMKLEEQIRWYRQTGAGRDNSSRFSLNGGANIEAIIAS----- 3642 + EE+ N L+ VMKLE ++ +Q+ GRD +RF N +E + Sbjct: 74 EKAGEEQAKFENQLKTKVMKLENELEMAQQSAGGRD--TRFLRNEICQLEKQLEQKDREL 131 Query: 3643 ---EKEVWNREKLTLQKSLKRAEAEVYKLKAELRNDSL 3677 EKE+ +K+ Q +L+ EAE K N L Sbjct: 132 EDMEKELEKEKKVNEQLALRNEEAENENSKLRRENKRL 169 >gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] Length = 2230 Score = 231 bits (588), Expect = 1e-59 Identities = 461/2378 (19%), Positives = 994/2378 (41%), Gaps = 338/2378 (14%) Query: 236 QKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFT 295 QK+ + QQLQ + ++ +S+ ++++ T Q + D Q + Sbjct: 7 QKISEEQQQLQQALAPAQASSNSSTPTRMRSRTSSFTEQLDEGTPNRESGDTQSFAQKLQ 66 Query: 296 MQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLEL-KDKLTT 354 +++ ++ ++ + + S+ +E + + E LN ++ + + D + Sbjct: 67 LRVPSVES---LFRSPIKESLFRSSSKESLVRTSSRESLNRLDLDSSTASFDPPSDMDSE 123 Query: 355 ADKLLGEL----QEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHK 410 A+ L+G +EQ++Q+ ++ M+ L++ + K + + T ++ +R K Sbjct: 124 AEDLVGNSDSLNKEQLIQR---LRRMERSLSSYRGKYSE--------LVTAYQMLQREKK 172 Query: 411 DSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGE 470 Q I+ + + ++ R++ +LR EL Q Q K+ L + A +EE K + Sbjct: 173 KLQ---GILSQSQDKSLRRIAELREEL-----QMDQQAKKHLQEEFDASLEE-----KDQ 219 Query: 471 MENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNS--QKEKLKEELGLILEEKCALQR 528 + L++ ++ + MNV + + +L+ KE+ E G + E + Sbjct: 220 YISVLQTQVSLLKQRLRNGPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVK 279 Query: 529 QLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELK 588 LE L + + ++R ++TI + + +++ E + E K+L + Sbjct: 280 TLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMA 339 Query: 589 HEA----EVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDL 644 + ++ + K +E LE++K V+ AE +R + L EEE+++L+ + Sbjct: 340 EKTKLITQLRDAKNLIEQLEQDKGMVI--------AETKRQMHETLEMKEEEIAQLRSRI 391 Query: 645 EIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKD-NLITKQNQLILEISKLK 703 + + E+L++ Q E S++ + EK + K + ++ Sbjct: 392 K-QMTTQGEELRE-------------QKEKSERAAFEELEKALSTAQKTEEARRKLKAEM 437 Query: 704 DLQQSLVNSKSEEMTLQINELQKEIEILRQEEKE--KGTLEQEVQELQLKTELLEKQMKE 761 D Q + SEE + LQ+E+ ++QE + K + E+++ +LQ +L EK++ Sbjct: 438 DEQIKTIEKTSEEERIS---LQQELSRVKQEVVDVMKKSSEEQIAKLQ---KLHEKELAR 491 Query: 762 KENDLQEKFAQLEAE--NSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWE 819 KE +L +K E E + +K+ + LKI Q+E L L+ ++ + K + E Sbjct: 492 KEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLA-LEELELQKKAILTE 550 Query: 820 KEIEI--LIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEY-----ACLL 872 E ++ L +E E + + ++L +EK K+ V+ + + ++ + Sbjct: 551 SENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVE 610 Query: 873 KVKDDLEDSKNKQELEYKSKLKALNEELH--LQRINPTTVKMKSSVF-DEDKTFVAETLE 929 K K +LE K++Q+ + KL+ L ++ ++++ + K ++ D++ F A E Sbjct: 611 KHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEE 670 Query: 930 MGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQ 989 M E + +EKL+V + E LS S+LSE LK +H L EE+ LK + ++ Sbjct: 671 MNE-------KTLEKLDVKQTELESLS---SELSEVLKARHK----LEEELSVLKDQTDK 716 Query: 990 VSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIM 1049 + +ELE ++ + + Q D+ + + + T + + ++++ E K + Sbjct: 717 MK---QELEAKMDEQKNHHQQQVDSIIKE-HEVSIQRTEKALKDQINQLELLLKERDKHL 772 Query: 1050 VEDKVSFENMTVGEESKQEQL--------ILDHLPSVTKESSLRATQPSENDKLQKELNV 1101 E + EN+ + + +L + S T E + + +LQ++L Sbjct: 773 KEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQT--KAYEEQLAQLQQKLLD 830 Query: 1102 LKSEQNDLRLQ---MEAQRICLSLVYSTHVDQVREYME------NEKDKALCSLKEELIF 1152 L++E+ L Q +EAQ+ + H QV++ M+ +E ++ + SL + Sbjct: 831 LETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYES 890 Query: 1153 AQEEKIKELQKIHQL--ELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVL 1210 E+ KE ++ Q+ E + M Q + K + +L KL + E+ + +L Sbjct: 891 KLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKL--SAKEDSIH-------IL 941 Query: 1211 GEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKL 1270 E Y K N++ +++ + + ++ QE TL K+ ++ KL Sbjct: 942 NEEYETKFK-----------------NQEKKMEKVKQKAKEMQE---TLKKKLLDQEAKL 981 Query: 1271 LVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQD 1330 + Q+ + +F + L + I ++ LE N K ++ SL + Sbjct: 982 KKELENTALELSQK----EKQFNAKMLEMAQANSAGISDAVSRLE---TNQKEQIESLTE 1034 Query: 1331 LEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSESTVPPSLPVDSVV 1390 + + +L + + E L QQ +E ++ +E + LQ++ Q V+E Sbjct: 1035 VHRRELNDVISIWE---KKLNQQAEELQEIHEIQ---LQEKEQEVAEL------------ 1076 Query: 1391 ITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVS 1450 Q+ + G C K+ ++ I + E GVK++T + +L E+ Q+ + Sbjct: 1077 -----KQKILLFG-CEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDET 1130 Query: 1451 MSIAFAQQTELSRISGGKENTASSKQ---AHAVCQQEQHYFNEM--KLSQDQIGFQTFET 1505 A ++ E+ KENT +Q + ++++ +E+ KL FQ+ ++ Sbjct: 1131 KLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKS 1190 Query: 1506 VDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSI 1565 K + + S E + +E L I ++ K ++ Sbjct: 1191 SHEKSNKSLEDKSLEFKKLSEE------------------LAIQLDICCKKTEALLEAKT 1232 Query: 1566 HDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQ 1625 ++ I++SS + +L+ R V++ + T +A +RQ+ E+Q Sbjct: 1233 NELINISS--SKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQL---TEEQNT 1287 Query: 1626 LQEEIKRLNRQLAQRSS------IDNENLVSERERVLLEELEALKQLSLAGREKLCCELR 1679 L ++ QL ++ + D E+LV+E+E + + E Q A ++ C Sbjct: 1288 LNISFQQATHQLEEKENQIKSMKADIESLVTEKEAL---QKEGGNQQQAASEKESCI--- 1341 Query: 1680 NSSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVV 1739 TQ E + T ++EL K ++ LS + Sbjct: 1342 -----TQLKKELSENINAVTLMKEELKEKKVEI--SSLSKQ------------------- 1375 Query: 1740 KTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDE-SIPSY 1798 + D + + Q+S SL + A +S++ EE + D+ S+ Sbjct: 1376 ----------------LTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSF 1419 Query: 1799 SGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEK-- 1856 + + I+ +V + + S+ ++ T+ +EL + + + + A EK Sbjct: 1420 KVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDE 1479 Query: 1857 ----LLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQ 1912 L E + + + + + K + + +++ LK Q R+ E Q Sbjct: 1480 QINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQ---TARIMELEDHITQ 1536 Query: 1913 LAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEE 1972 +E+ V+ Y +K + +++ +K L +E NR++E E E+ Sbjct: 1537 KTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEE---KDNRVKEAE-------EK 1586 Query: 1973 RELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEE 2032 L Q +MKAE +++L + ++ E++ +++ + ++ L+ E+ Sbjct: 1587 ILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQ 1646 Query: 2033 QVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLE- 2091 +++ K L + ++ + +K E L+ + +RE E + +++++ +E Sbjct: 1647 KIAAI------KKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVES 1700 Query: 2092 --QQLKVVPRFQPISEHQTREVEQLANHLKEKT--DKCSEL---LLSKEQLQRDIQERNE 2144 + +VPR T + E + +KT +K S L L KE+L + + + E Sbjct: 1701 SQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKE 1760 Query: 2145 EIEKLEFRVRELEQALLVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQL 2204 E F +R Q L++ +H A + + + S+ LQ E + ++K I + Sbjct: 1761 ETVSSHFEMRCQYQERLIK-LEHAEAKQHEDQ-SMIGHLQEELEEKNKKYSLIVAQHVEK 1818 Query: 2205 E------QFREELENKNEEVQQLHMQLEIQKKESTTRLQELE----QENKLFKDDMEKLG 2254 E Q ++ LEN ++VQ+ + E+ + +++EL+ ++ ++ + +ME+L Sbjct: 1819 EGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELT 1878 Query: 2255 LAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDN---KVIEE 2311 ++ A+ D K ++++E E + + KL ++ ++ K+ Sbjct: 1879 SKYEKLQALQQMDGR---NKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGA 1935 Query: 2312 KNELIRDLETQIECLMSDQECVKRNREEEIEQL-----NEVIEKLQQELANIGQKTSMNA 2366 + E + L +I L D +++ ++E+E L E EK++QE ++ K + Sbjct: 1936 EREK-QKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTL 1994 Query: 2367 HSLSEEADS----LKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQEL 2422 L E ++ + +L++ I E + Q+VE +++ +ETN + ++ ++ Sbjct: 1995 KQLMREFNTQLAQKEQELEMTIKETINKAQEVEA-----ELLESHQEETNQLLKKIAEKD 2049 Query: 2423 FSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENG 2482 LKR + E+I E + + L EL+ K + + + N Sbjct: 2050 DDLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQ--------KKYQQKLEQEENPGND 2101 Query: 2483 KGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQ 2520 +I+ L+T+L Q + +S L+ + +QI +++++ Sbjct: 2102 NVTIMELQTQLAQKTTLISDSKLKEQEFREQIHNLEDR 2139 Score = 223 bits (569), Expect = 2e-57 Identities = 438/2257 (19%), Positives = 926/2257 (41%), Gaps = 375/2257 (16%) Query: 693 NQLILEISKLKDLQQSLVNSKSEEMTLQINELQKE--IEILRQEEKEKGTLEQEVQELQL 750 N+L L+ S S ++S++E++ + L KE I+ LR+ E+ + + EL Sbjct: 103 NRLDLDSSTASFDPPSDMDSEAEDLVGNSDSLNKEQLIQRLRRMERSLSSYRGKYSELVT 162 Query: 751 KTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIK 810 ++L+++ K+ + L + + + L++E + ++ K H QEE F S++ Sbjct: 163 AYQMLQREKKKLQGILSQSQDKSLRRIAELREELQ-MDQQAKKHL---QEE---FDASLE 215 Query: 811 SKSKD-SVWEKEIEILIEE------NEDLKQQCIQLNEEIE---KQRNTFSFAE------ 854 K + SV + ++ +L + N D+ + QL + E K+ N S E Sbjct: 216 EKDQYISVLQTQVSLLKQRLRNGPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDG 275 Query: 855 ---KNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEEL-----HLQRIN 906 K E Q ++ + L + K+ ++ K + L S+ +AL E+L L++I Sbjct: 276 TSVKTLETLQQRVKRQENLLKRCKETIQSHKEQCTL-LTSEKEALQEQLDERLQELEKIK 334 Query: 907 PTTVKMKSSVFDE--DKTFVAETLEM--GEVVEKDTTELMEKLEVTKREKLELSQRLSDL 962 + K+ + + D + E LE G V+ + ++ E LE+ + E +L R+ + Sbjct: 335 DLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQM 394 Query: 963 SEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDG 1022 + Q EE++ K++ E+ + ELE ++ A+ + ++ + +D Sbjct: 395 TTQ-----------GEELREQKEKSERAAFE--ELEKALS--TAQKTEEARRKLKAEMDE 439 Query: 1023 VVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKES 1082 + + +E E+++S + E S+ +Q ++D + ++E Sbjct: 440 QIKTIEKTSE------------------EERISLQQ----ELSRVKQEVVDVMKKSSEEQ 477 Query: 1083 SLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKA 1142 + + E + +KE + K Q + RE+ E K Sbjct: 478 IAKLQKLHEKELARKEQELTKKLQT----------------------REREFQEQMKVAL 515 Query: 1143 LCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYF 1202 S E L +QE++ +E + +LELQ +KA+ E Sbjct: 516 EKSQSEYLKISQEKEQQESLALEELELQ---------------------KKAILTESENK 554 Query: 1203 LQTLCSVLGEYYTPALKCEVNAE----DKENSGDYISENEDPELQDYRYEVQDFQENMHT 1258 L+ L Y T L+ E + E + +N ++ + + E + E+ E T Sbjct: 555 LRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKT 614 Query: 1259 LLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDID 1318 L + + + L W ++ +K ++ E E+ + T L+D + Sbjct: 615 ELESLKHQQDAL----------WTEKLQVLKQQYQTE---MEKLREKCEQEKETLLKDKE 661 Query: 1319 VNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSES 1378 + ++ + + + KL+ + ELESL S L + LK H L++ L + + Sbjct: 662 IIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKAR--------HKLEEELSVLKDQ 713 Query: 1379 TVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQE 1438 T +++ + E S +K++ + +I+ + E +K++ N ++LL K+ + Sbjct: 714 TDKMKQELEAKM-DEQKNHHQQQVDSIIKEH-EVSIQRT-EKALKDQINQLELLLKERDK 770 Query: 1439 QLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQI 1498 L+E QAH + +E +L Q Sbjct: 771 HLKEH--------------------------------QAHVENLEADIKRSEGELQQASA 798 Query: 1499 GFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKT 1558 F++ E+ K ++L + +++L ++ Sbjct: 799 KLDVFQSYQSATHEQTKAYEEQLAQLQQKLL----------------------DLETERI 836 Query: 1559 FIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMER 1618 + +Q E+ D +L ++ Q++D+ Q+L +Q E +Q + L Q + ++E Sbjct: 837 LLTKQVA--EVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLED 894 Query: 1619 QREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCEL 1678 ++QEQ ++ + ++ EN++ + +E+E L Q A + + + Sbjct: 895 GNKEQEQTKQIL------------VEKENMILQMREGQKKEIEILTQKLSAKEDSI--HI 940 Query: 1679 RNSSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEV 1738 N +T+ N+ + ++E+ K KE+ E + ++L E ++ N L++ + Sbjct: 941 LNEEYETKFKNQEK-KMEKVKQKAKEMQ---ETLKKKLLDQEAKLKKELENTALELSQKE 996 Query: 1739 VKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSY 1798 + A + E + GI D S+ +++ S E + + + ++ + Sbjct: 997 KQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRREL--NDVISIWEKKLNQQ 1054 Query: 1799 SGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEEL--MLNISSRLQAAVEK 1856 + ++I + K +E EL Q+++ G E + N+E+ + + + + Sbjct: 1055 AEELQEIHEIQLQEK-EQEVAELKQKIL---LFGCEKEEMNKEITWLKEEGVKQDTTLNE 1110 Query: 1857 LLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERL-------HEESRA 1909 L E + + S+ + +T+L + + + +SLK L+E+L E+ R Sbjct: 1111 LQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRK 1170 Query: 1910 REQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQEL-----LCASNRLQELEA 1964 +L +L + + +++K+ +L +EL +C LEA Sbjct: 1171 VSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEA 1230 Query: 1965 EQQQI-----QEERELLSR----------QKEAM---KAEAGPVEQQLLQETEKLMKEKL 2006 + ++ + +LSR KEA+ +E QL Q TE+ + Sbjct: 1231 KTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNI 1290 Query: 2007 EVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMR 2066 Q QA ++ + Q+K+++ D+E V+ L++E + ++ + + +++ Sbjct: 1291 SFQ-QATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELS 1349 Query: 2067 KFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTD--K 2124 + ++ + +E ++ + EI L +QL + Q + E E + L+++ D K Sbjct: 1350 ENINAVTLMKEELKEK-KVEISSLSKQLTDL-NVQLQNSISLSEKEAAISSLRKQYDEEK 1407 Query: 2125 C------SELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVEDRKHFGAVEAKPELS 2178 C +L + L ++ E+++ + E ++ +H V+ Sbjct: 1408 CELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVK-----E 1462 Query: 2179 LEVQLQAERDAIDRKEKEITNLEEQLEQ-------FREELENKNEEVQQLHMQLEIQKKE 2231 L++QL+ + K+++I L+E+L+Q + E+E+ ++++ LE + K Sbjct: 1463 LQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKS 1522 Query: 2232 STTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNE 2291 T R+ ELE ++E L +K + Q+K++E +L Sbjct: 1523 QTARIMELEDHITQKTIEIESLNEVLKNYN------------------QQKDIEHKEL-- 1562 Query: 2292 QVTKLQ--QQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIE 2349 V KLQ Q+L DN+V +E E I LE Q+ + ++ E +++E+E +N ++ Sbjct: 1563 -VQKLQHFQELGEEKDNRV-KEAEEKILTLENQVYSMKAELE----TKKKELEHVNLSVK 1616 Query: 2350 KLQQELANIGQK-TSMNAHSLSEEADSLKHQLDVVIA--EKLALEQQVETANEEMTFMKN 2406 ++EL + + S +A L+E LK + + IA +K L Q E + ++ Sbjct: 1617 SKEEELKALEDRLESESAAKLAE----LKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTES 1672 Query: 2407 VLKETNFKMNQLTQELFSLKRERESVEKIQS----IPENSVNVAIDHLSKDKPELEVVLT 2462 L E N K+ + +E+ L+ + +SVE QS +P ++ NVA Sbjct: 1673 HLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVA---------------- 1716 Query: 2463 EDALKSLENQTYFKSFEENGKGSI-INLETRLLQLESTVSAKDLELTQCYKQIKDMQEQG 2521 Y + E + +G + E ++ L+ ++ K+ +L Q Q K+ Sbjct: 1717 ----------AYTEQEEADSQGCVQKTYEEKISVLQRNLTEKE-KLLQRVGQEKEETVSS 1765 Query: 2522 QFETE-MLQKKIVNLQKI-VEEKVAAALVSQIQLEAVQEYAKFCQ-DNQTISSEPERTNI 2578 FE Q++++ L+ ++ +++ +Q E ++ K+ Q + E + NI Sbjct: 1766 HFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNI 1825 Query: 2579 QNLNQLRE--DELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLL 2636 Q L D++ + L LE ++ E+ + L+ +KE + + + K +KL Sbjct: 1826 QAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQ 1885 Query: 2637 ELQKLLEGNEK-----KQREKEKKRSPQDVEVLKTTTELFHSNEE---SGFFNELEALRA 2688 LQ+ ++G K ++ +EK +S L + E H++ E +G E + L Sbjct: 1886 ALQQ-MDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGK 1944 Query: 2689 ESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDET 2748 E V + +L + K + + E+L KE + +K + D + L L +E T Sbjct: 1945 EIVRLQKDLRMLR-KEHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNT 2003 Query: 2749 EVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQS------ 2802 ++ + ++ + IK + + A + + L S +T Q+L K A +L+ Sbjct: 2004 QLAQKEQEL---EMTIKETINKAQEVEAELLESHQEETNQLLKKIAEKDDDLKRTAKRYE 2060 Query: 2803 ---ECSSEEVTEIISQFTEKIEKMQELHAAEILDMES 2836 + EE+T + ++E++Q+ + ++ E+ Sbjct: 2061 EILDAREEEMTAKVRDLQTQLEELQKKYQQKLEQEEN 2097 Score = 218 bits (555), Expect = 9e-56 Identities = 399/1886 (21%), Positives = 822/1886 (43%), Gaps = 314/1886 (16%) Query: 157 LEMMESELAGKQHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQ 216 LEM E E+A + I+++ + EE+R +E E A+ ++ Sbjct: 377 LEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKAL--------STAQKTEE 428 Query: 217 ARR----EKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILT 272 ARR E DE ++ +E T + +++ +Q + + + + + S+ + AK Q L Sbjct: 429 ARRKLKAEMDEQIKT-IEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQI--AKLQKLH 485 Query: 273 HQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKV-YEMEQDKKVENSNKEEIQEKETII 331 ++ ++ L + Q ++ +F QE++KV E Q + ++ S ++E QE + Sbjct: 486 EKELARKEQELTKKLQTREREF-------QEQMKVALEKSQSEYLKISQEKEQQESLALE 538 Query: 332 E-ELNTKII--EEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKER 388 E EL K I E E K +L+ + T + EL+ + + QE KN +L + E Sbjct: 539 ELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDL--AVHLEA 596 Query: 389 QSSEEIKQLMGTVE----ELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQ 444 + ++ K++ VE EL+ H+ T+ +Q ++Q+ Q ++E+LR E E + Sbjct: 597 EKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLR-EKCEQEKET 655 Query: 445 IVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQD 504 +++ K+ + + H+ +M E + L S S+ + +K + EL++ Sbjct: 656 LLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSEL--SEVLKARHKLEEELSVLKDQ 713 Query: 505 TNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRA-RQTIAEQESKLNEAHK 563 T+ K++L+ ++ E+K Q+Q++ +++E S ++ ++A + I + E L E K Sbjct: 714 TDKMKQELEAKMD---EQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDK 770 Query: 564 SL----STVEDLKAEIVSASESRKELELK-----------------HEAEVTNYKIKLEM 602 L + VE+L+A+I + ++ K +E ++ + KL Sbjct: 771 HLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLD 830 Query: 603 LEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIH 662 LE E+ + ++AE EA+ + + T+ L +H+ ++ L + LE ++ +K+K ++ Sbjct: 831 LETERILLTKQVAE-VEAQKKDVCTE-LDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVY 888 Query: 663 YKQQIDGLQNEMSQKIETMQFEKDNLITK----QNQLILEISKLKDLQQSLVNSKSEEMT 718 + DG N+ ++ + + EK+N+I + Q + I +++ ++ ++ +EE Sbjct: 889 ESKLEDG--NKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYE 946 Query: 719 LQINELQKEIEILRQEEKE-KGTLEQEV--QELQLKTEL--LEKQMKEKENDLQEKFAQL 773 + +K++E ++Q+ KE + TL++++ QE +LK EL ++ +KE K ++ Sbjct: 947 TKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEM 1006 Query: 774 EAENSI-LKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKD---SVWEKEIEILIEEN 829 NS + D LE +Q+E++ L + + + S+WEK++ EE Sbjct: 1007 AQANSAGISDAVSRLE--------TNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEEL 1058 Query: 830 EDLKQQCIQLNEEIEKQRNTFSFAEK--NFEVNYQELQEEYACLLK--VKDDLEDSKNKQ 885 +++ + IQL EK++ +K F +E+ +E L + VK D ++ ++ Sbjct: 1059 QEIHE--IQLQ---EKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQE 1113 Query: 886 ELEYKS-----------KLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETL-EMGEV 933 +L+ KS KLKA HL+++ V + S+ ++ TF+ E L E+ + Sbjct: 1114 QLKQKSAHVNSLAQDETKLKA-----HLEKLE---VDLNKSL--KENTFLQEQLVELKML 1163 Query: 934 VEKD---TTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQV 990 E+D +EL KL+ T E L ++ L+ K E L+EE+ Q+ Sbjct: 1164 AEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAI------QL 1217 Query: 991 SLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAE---------GSVSKVNKS 1041 + C++ E ++ E + ++ +++L + R + +VS++ Sbjct: 1218 DICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQ 1277 Query: 1042 FGEESKIMVEDKVSFENMTVGEESKQEQL---------ILDHLPSVTKESSLRATQPSEN 1092 + ++ +SF+ T E K+ Q+ ++ ++ KE + SE Sbjct: 1278 LRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEK 1337 Query: 1093 D----KLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMEN-----EKDKAL 1143 + +L+KEL+ + ++ +++ +++ +S + S + + ++N EK+ A+ Sbjct: 1338 ESCITQLKKELSENINAVTLMKEELKEKKVEISSL-SKQLTDLNVQLQNSISLSEKEAAI 1396 Query: 1144 CSLKEELIFAQEEKIKELQKIHQLELQT-MKTQETGDEGKPLHLLIGKLQKAVSEECSYF 1202 SL+++ EEK + L ++ L + ++E + + K + + S F Sbjct: 1397 SSLRKQY---DEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRF 1453 Query: 1203 LQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDP----------ELQDYRYEVQDF 1252 Q +V LK + A +K+ + + E D E++D + +++ Sbjct: 1454 TQHQNTVKELQIQLELKSK-EAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKK 1512 Query: 1253 QENMHT------------------------LLNKVTEEYN-------KLLVLQTRLSKIW 1281 + N+ T LN+V + YN K LV + + + Sbjct: 1513 ESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQEL 1572 Query: 1282 GQQTDGMKLEFGEENLPKEETEF---LSIHSQMTNLEDIDVNHKSKLSSLQDLE------ 1332 G++ D E E+ L E + + ++ LE ++++ KSK L+ LE Sbjct: 1573 GEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESE 1632 Query: 1333 -KTKLEEQVQELESLISSLQQQL----KETEQNY------------------EAEIHCLQ 1369 KL E ++ E I+++++QL +E E+ Y E E+H L+ Sbjct: 1633 SAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILE 1692 Query: 1370 KRLQAV----SESTVPPSLPVDSVVITESD-------AQRTMYPG-SCVKKNI------- 1410 ++L++V SE+ + P + TE + Q+T S +++N+ Sbjct: 1693 EKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLL 1752 Query: 1411 -------DGTIEFSGEFGVKEETNIVKLLE---KQYQEQ-----LEEEVAKVIVSMSIAF 1455 + T+ E + + ++KL KQ+++Q L+EE+ + S+ Sbjct: 1753 QRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIV 1812 Query: 1456 AQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVD---VKFKE 1512 AQ E GGK N + + V Q E +L+ QI Q + +D V+ KE Sbjct: 1813 AQHVEK---EGGKNNIQAKQNLENVFDDVQKTLQEKELT-CQILEQKIKELDSCLVRQKE 1868 Query: 1513 EFKPLSKEL-GEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISV 1571 + +EL ++ K L D + P + E K K+ +V+ + + Sbjct: 1869 VHRVEMEELTSKYEKLQALQQMDGRNKPTE-----LLEENTEEKSKSHLVQPKLLSNMEA 1923 Query: 1572 SSMDASRQLMLNEEQLEDMRQELVRQY-------QEHQQATELLRQAHMRQMERQ-REDQ 1623 D +L E + + + +E+VR +EHQQ E+L++ + ++ E + +++Q Sbjct: 1924 QHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQ 1983 Query: 1624 EQLQ--------EEIKRLNRQLAQRS---SIDNENLVSERERVLLEELEALKQLSLAGRE 1672 E L+ + ++ N QLAQ+ + + +++ + V E LE+ ++ + + Sbjct: 1984 EDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEVEAELLESHQEETNQLLK 2043 Query: 1673 KLCCELRNSSTQTQNGNEN--QGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNR 1730 K+ E + +T E EE T K ++L + E++ + ++ Q+ N Sbjct: 2044 KI-AEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQKKY---QQKLEQEENPG 2099 Query: 1731 LLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRV 1790 + + ++T A + T+ I D K Q I E +E++ Sbjct: 2100 NDNVTIMELQTQLAQKTTL------ISDSKLKEQEFREQIHNLEDRLK----KYEKNVYA 2149 Query: 1791 TDESIPSYSGSDMPRNDINMWSKVTE 1816 T P Y G ++ D++++ + TE Sbjct: 2150 TTVGTP-YKGGNLYHTDVSLFGEPTE 2174 Score = 197 bits (500), Expect = 2e-49 Identities = 456/2174 (20%), Positives = 900/2174 (41%), Gaps = 371/2174 (17%) Query: 1762 KSQSSASLIWRSEAEASVKSCVHEEHTRVT-DESIPSY---SGSDMPRNDINMWSKVTEE 1817 +S SL S E+ V++ E R+ D S S+ S D D+ + + + Sbjct: 77 RSPIKESLFRSSSKESLVRTSSRESLNRLDLDSSTASFDPPSDMDSEAEDL-VGNSDSLN 135 Query: 1818 GTELSQRLVR-----SGFAGTEIDPENEELMLNISSR-----LQAAVEKLLEAISETSSQ 1867 +L QRL R S + G + ML + L + +K L I+E + Sbjct: 136 KEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGILSQSQDKSLRRIAELREE 195 Query: 1868 LEHAKVTQTELMRE---SFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVI 1924 L+ + + L E S +K + L+ Q L ++ + L + E Sbjct: 196 LQMDQQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQRLRNGPMNVDVLKPLPQLEPQA 255 Query: 1925 DGYADEKTLF---ERQIQEKTDI--IDRLEQELLCASNRLQELEAEQQQIQEERELLSRQ 1979 + + E+ E +++ T + ++ L+Q + N L+ + Q +E+ LL+ + Sbjct: 256 EVFTKEENPESDGEPVVEDGTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSE 315 Query: 1980 KEAMKAEAGPVEQQLLQETEKL----MKEKLEVQCQ---AEKVRDDLQKQVKALEIDVEE 2032 KEA++ + + LQE EK+ M EK ++ Q A+ + + L++ + + + Sbjct: 316 KEALQEQL----DERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKR 371 Query: 2033 QVSRFIELEQEKNTELM-----------DLRQQN--------QALEKQL----------E 2063 Q+ +E+++E+ +L +LR+Q + LEK L Sbjct: 372 QMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARR 431 Query: 2064 KMRKFLDEQ--AIDR--EHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLK 2119 K++ +DEQ I++ E ER QQE+ +++Q+ VV + SE Q ++++L H K Sbjct: 432 KLKAEMDEQIKTIEKTSEEERISLQQELSRVKQE--VVDVMKKSSEEQIAKLQKL--HEK 487 Query: 2120 EKTDKCSELLLSKEQLQRDIQER------------------NEEIEKLEFRVRELE-QAL 2160 E K EL + +R+ QE+ E+ E L EL+ +A+ Sbjct: 488 ELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAI 547 Query: 2161 LVEDRKHFGAVEAKPEL----------SLEVQLQAERDAID--------RKEKEITNLEE 2202 L E ++ + E SLE LQ ++ K K + Sbjct: 548 LTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITV 607 Query: 2203 QLEQFREELENKNEEVQQLHMQ-LEIQKKESTTRLQEL----EQENK-LFKD-------- 2248 +E+ + ELE+ + L + L++ K++ T +++L EQE + L KD Sbjct: 608 MVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAH 667 Query: 2249 -------DMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLK 2301 +EKL + E +++S++ VL + + E E+ L +Q K++Q+L+ Sbjct: 668 IEEMNEKTLEKLDVKQTELESLSSELSEVLKAR-----HKLEEELSVLKDQTDKMKQELE 722 Query: 2302 ITTDNK-----------------VIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQL 2344 D + I+ + ++D Q+E L+ +++ + + +E L Sbjct: 723 AKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENL 782 Query: 2345 NEVIEKLQQELANIGQK----------TSMNAHSLSEEADSLKHQLDVVIAEKLALEQQV 2394 I++ + EL K T + E+ L+ +L + E++ L +QV Sbjct: 783 EADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQV 842 Query: 2395 ETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDK 2454 + + L ++ L Q+L K+ E +K++S+ + ++ +K++ Sbjct: 843 AEVEAQKKDVCTELDAHKIQVQDLMQQL--EKQNSEMEQKVKSLTQ-VYESKLEDGNKEQ 899 Query: 2455 PELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYK-Q 2513 + + +L +E + E K I L +L E ++ + E +K Q Sbjct: 900 EQTKQIL-------VEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQ 952 Query: 2514 IKDMQEQGQFETEM---LQKKIVNLQ-KIVEEKVAAAL-VSQIQLEAVQEYAKFCQDNQT 2568 K M++ Q EM L+KK+++ + K+ +E AL +SQ + + + + Q N Sbjct: 953 EKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSA 1012 Query: 2569 ISSEP-------ERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQV 2621 S+ ++ I++L ++ EL IS ++++ ++ E+H + EKEQ Sbjct: 1013 GISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQ- 1071 Query: 2622 EIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFN 2681 E+AE L+ + LL G EK++ KE + E +K T L E Sbjct: 1072 EVAE----------LKQKILLFGCEKEEMNKEITWLKE--EGVKQDTTLNELQE------ 1113 Query: 2682 ELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSI 2741 +L+ A + + K EKL+ +L T LQ+ L +++ E K K+S Sbjct: 1114 QLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSE 1173 Query: 2742 LEKEDETEVQE----------SKKACMFEPLPI-KLSKSIASQTDGTLKISSSNQTPQIL 2790 L + +T +E S K+ + L KLS+ +A Q D K +T +L Sbjct: 1174 LTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCK-----KTEALL 1228 Query: 2791 VKNAGIQINLQSECSSEEVTEI--ISQFTEKIEKMQELHAAEILDMES--RHISETE-TL 2845 IN+ S ++ ++ I T K+++ + + ++E+ R ++E + TL Sbjct: 1229 EAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTL 1288 Query: 2846 KREHYVAVQLLKE---ECGTLKAVIQCL-RSKEGSSIPELAHSDAYQTREICSSDSGSDW 2901 A L+E + ++KA I+ L KE A +E C + + Sbjct: 1289 NISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKEL 1348 Query: 2902 GQGIYLTHSQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGE 2961 + I ++ +E + S K++ L + N +SL+E + Sbjct: 1349 SENINAVTLMKEEL------KEKKVEISSLSKQLTDLNVQLQNS----ISLSE------K 1392 Query: 2962 DHSIQQVSEPWLEERKAYINTISSLK---DLITKMQLQREAEVYDSSQSHESFSDWRGEL 3018 + +I + + + EE+ ++ + L D ++K ++ +V D S FS+W+ + Sbjct: 1393 EAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWS---NKFSEWKKK- 1448 Query: 3019 LLALQQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQ--- 3075 A + + +V + EL + + +N L++ + +Q + +CL+ Sbjct: 1449 --AQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRF----DCLKGEM 1502 Query: 3076 KADRRSLLSEIQALHAQMNGRKITL--------KREQESEKPSQELLEYNIQQKQSQMLE 3127 + D+ + + L ++ + + ++ E E ++ L YN QQK + E Sbjct: 1503 EDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYN-QQKDIEHKE 1561 Query: 3128 MQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLE 3187 + +L ++ E ++ + + L++++ K ELET KELE L Sbjct: 1562 LVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELET-------KKKELEHVNLS 1614 Query: 3188 VKDKTDEVHLLNDTLASE--------QKKSRELQWALEKE-KAKLGRSEERDKEELEDLK 3238 VK K +E+ L D L SE ++K+ + A++K+ +++ EE+ K+ E Sbjct: 1615 VKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHL 1674 Query: 3239 FSLESQ-KQRNLQLNLLLEQQKQLLNE------------------SQQKIESQ---RMLY 3276 L ++ ++R ++++L E+ K + + Q++ +SQ + Y Sbjct: 1675 SELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTY 1734 Query: 3277 DAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSED- 3335 + ++S Q E + LL+ +E T+ E+ Q Q + ED Sbjct: 1735 EEKISVLQRNLTEKEKLLQRVG---QEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQ 1791 Query: 3336 -LLKELQKQLEE---KHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANT 3391 ++ LQ++LEE K+S IV E E K +++Q +Q +E +KTLQ ++ Sbjct: 1792 SMIGHLQEELEEKNKKYSLIVAQHVEKEGGK-NNIQAKQNLENVFDDVQKTLQEKELTCQ 1850 Query: 3392 EGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQ---EFQKQELEREEKRES 3448 ++K+ EL S L RQ E R ++ +L + ++LQ + Q + EL E E Sbjct: 1851 ILEQKIKELDS---CLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEK 1907 Query: 3449 RRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMIR 3508 + +L +P L++ ++ L+ K+ G +E ++ +L M+R Sbjct: 1908 SK---SHLVQPKL--LSNMEAQHNDLEFKLAGAEREKQ-----KLGKEIVRLQKDLRMLR 1957 Query: 3509 QKLQCVASKLQVLPQKASERLQFETADDEDFIWVQEN--IDEIILQLQKLTGQQGEEPSL 3566 ++ Q +L++L ++ + + + +++ + ++ N + +++ + Q+ +E + Sbjct: 1958 KEHQ---QELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEM 2014 Query: 3567 VSPST--SCGSLTERLLRQNAELTGHISQLTEEKND-----------------------L 3601 T + LL + E T + + EK+D + Sbjct: 2015 TIKETINKAQEVEAELLESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKV 2074 Query: 3602 RNMVMKLEEQIRWYRQ-----TGAGRDNSSRFSLNGGANIEAIIASE---KEVWNREKL- 3652 R++ +LEE + Y+Q G DN + L + + S+ KE RE++ Sbjct: 2075 RDLQTQLEELQKKYQQKLEQEENPGNDNVTIMELQTQLAQKTTLISDSKLKEQEFREQIH 2134 Query: 3653 TLQKSLKRAEAEVY 3666 L+ LK+ E VY Sbjct: 2135 NLEDRLKKYEKNVY 2148 >gi|21735548 centrosomal protein 2 [Homo sapiens] Length = 2442 Score = 210 bits (534), Expect = 3e-53 Identities = 507/2513 (20%), Positives = 1031/2513 (41%), Gaps = 395/2513 (15%) Query: 542 EQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLE 601 EQ+ +Q +AE ++ K+ + +A +V K +A+V Y+ + Sbjct: 22 EQVLALQQQMAENQAASWRKLKNSQEAQQRQATLVR----------KLQAKVLQYRSWCQ 71 Query: 602 MLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEI--EHRINIEKLK--- 656 LEK A + + E E +LL EEE + + E+ + R+++EK Sbjct: 72 ELEKRLEATGGPIPQRWENVEEPNLDELLVRLEEEQQRCESLAEVNTQLRLHMEKADVVN 131 Query: 657 -------DNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLI------------- 696 + L + + + D L + SQ +F K L + +L+ Sbjct: 132 KALREDVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLLSLWREVVTFRRHF 191 Query: 697 LEISKLKDLQQSLVNSKSEEMTLQINELQ--KEIEILRQEEKEKGTLEQEVQE------L 748 LE+ D + L+ K+E + L + L + + Q + G+ + +E L Sbjct: 192 LEMKSATD--RDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGREPAQLLLL 249 Query: 749 QLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDS 808 KT+ LEK+ E+ +L + +Q + E + L+D L +L SQ++ + Sbjct: 250 LAKTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALL----TQSQKQNEDYEKM 305 Query: 809 IKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEY 868 IK+ + +EIL + +L + L+ ++++ + K+ E + Sbjct: 306 IKA------LRETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNI 359 Query: 869 ACLLKVKDDLE-DSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAET 927 A ++ LE DS + +Y+ KAL + SV + V + Sbjct: 360 AQGSGHENSLELDSSIFSQFDYQDADKALT--------------LVRSVLTRRRQAVQDL 405 Query: 928 LEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEK 987 + ++ L ++ + + E L QRL L+ + G+ L EV SL +E+ Sbjct: 406 RQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKER 465 Query: 988 EQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESK 1047 E + EL + ++ + + L V + +G K + EE Sbjct: 466 ELLQKAREELR--------QQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQ--EELH 515 Query: 1048 IMVEDKVSFENMTVGEESKQEQ------LILDHLPSVTKESSLRATQPSEND----KLQK 1097 + V ++ + M +G E+KQ + + + L S E L + +E + ++ Sbjct: 516 LAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALARAEQ 575 Query: 1098 ELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEK---DKALCSLKEE--LIF 1152 + L S +N L+ ++ R + + + E + +K ++ L L+EE + Sbjct: 576 SIAELSSSENTLKTEVADLRAA-----AVKLSALNEALALDKVGLNQQLLQLEEENQSVC 630 Query: 1153 AQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGE 1212 ++ E ++ + Q++L + + K H L +LQKA Sbjct: 631 SRMEAAEQARNALQVDLAEAEKRREALWEKNTH-LEAQLQKAE----------------- 672 Query: 1213 YYTPALKCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLV 1272 E AE + + D E E E+Q E + QE T L ++ +E + Sbjct: 673 --------EAGAELQADLRDIQEEKE--EIQKKLSESRHQQEAATTQLEQLHQEAKR--- 719 Query: 1273 LQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSK-LSSLQDL 1331 Q + + E+ E L + Q + D+ + + LSS ++L Sbjct: 720 -----------QEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKEL 768 Query: 1332 EKTKLEEQVQELESLISSLQQQLK-------ETEQNYEAEIHCLQKRLQAV-SESTVPPS 1383 ++ L E Q+ S+I + QL+ + ++ + E+ CL+ L S++ Sbjct: 769 LESSLFE-AQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERD 827 Query: 1384 LPVDSVVITESDAQRTMYPGSCV-KKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEE 1442 + E + + + +K ++ E + + + K LE +E++E Sbjct: 828 AAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMEL 887 Query: 1443 EVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQT 1502 E+ QQTE+ I +E + ++ A+CQ M+L ++ Sbjct: 888 EMR--------LKEQQTEMEAIQAQREEERTQAES-ALCQ--------MQLETEKERVSL 930 Query: 1503 FETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVR 1562 ET+ ++ ++E S++L E L + + E + + ++ ++ + Sbjct: 931 LETL-LQTQKELADASQQL-----ERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAA 984 Query: 1563 QSIHDEISVSSMDASRQL---MLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQ 1619 + D+++ ++S L M ++Q+ED++ +LV Q ++ L + +++ R+ Sbjct: 985 RQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVA-----QDDSQRLVEQEVQEKLRE 1039 Query: 1620 REDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELR 1679 ++ ++Q+E++R +++S+ + E+ ++L+E ++++Q L Sbjct: 1040 TQEYNRIQKELER------EKASLTLSLMEKEQRLLVLQEADSIRQQEL----------- 1082 Query: 1680 NSSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQK-----ANNRLLKI 1734 S Q+ E QGE +E + + + L ++ ++ + L+ E L++ + L+ Sbjct: 1083 --SALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRA 1140 Query: 1735 LLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDES 1794 L + AA + R L+ + Q + AS+ S + + V ES Sbjct: 1141 SLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVC-ES 1199 Query: 1795 IPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAV 1854 P SG + ++W G E Q RS F + L+ +S+ Sbjct: 1200 RPELSGGG--DSAPSVW------GLEPDQNGARSLF-------KRGPLLTALSA------ 1238 Query: 1855 EKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLA 1914 EA++ +L H + +T+ R+ R + ++L ERL + + Q+ Sbjct: 1239 ----EAVASALHKL-HQDLWKTQQTRDVLRDQ---------VQKLEERLTDTEAEKSQVH 1284 Query: 1915 VELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERE 1974 EL + + +EK+ +E + + L + + +RL+ E ++ + Q ERE Sbjct: 1285 TELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERE 1344 Query: 1975 LLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEK---VRDDLQKQVKALEIDVE 2031 LL KE + A + E L +E + QA + +DL+ AL++ E Sbjct: 1345 LLQAAKENLTA-----------QVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNE 1393 Query: 2032 EQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLE 2091 E +E E+E+ L + + A K L++ L + +RE E + + +IQ+LE Sbjct: 1394 E-----VESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELE 1448 Query: 2092 QQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEF 2151 +Q E Q +E L+ LK++ E+ L +EQ+Q ++++ +E L Sbjct: 1449 KQ----------REMQKAALELLSLDLKKRN---QEVDLQQEQIQ-ELEKCRSVLEHLPM 1494 Query: 2152 RVRELEQALLVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREE- 2210 V+E EQ L V+ R+ +E E V L+ + +++K++ I + Q++ +++ Sbjct: 1495 AVQEREQKLTVQ-REQIRELEKDRETQRNV-LEHQLLELEKKDQMIESQRGQVQDLKKQL 1552 Query: 2211 --LENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKES----DAMS 2264 LE E+++ H ++E Q+K ++ELE + + + + L L ++E A S Sbjct: 1553 VTLECLALELEENHHKMECQQK----LIKELEGQRETQRVALTHLTLDLEERSQELQAQS 1608 Query: 2265 TQ--DQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQ 2322 +Q D A+ +QE++ E+ EQ+ +LQ+Q K L +DLE + Sbjct: 1609 SQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQ------------KEHLTQDLERR 1656 Query: 2323 IECLMSDQECVKRNREEEIEQ---LNEVIEKLQQELANIGQKTSMNAHSLSEEAD----- 2374 + LM +E ++ ++ Q L E +E+++ L G++ + + E A+ Sbjct: 1657 DQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGP 1716 Query: 2375 ------SLKHQLDVVIAEKLALEQQVETANE---EMTFMKNVLK-----------ETNFK 2414 SL+H + +++ +K E++VE E E+ +K+ L+ ET+ Sbjct: 1717 SKAQRGSLEH-MKLILRDK---EKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLL 1772 Query: 2415 MNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTY 2474 ++Q QE+ L+++ + + + E S+ +D + + + L +AL+ + Q Sbjct: 1773 LSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQEL--EALQQEQQQA- 1829 Query: 2475 FKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFE---TEMLQKK 2531 + EE K L+ L Q T+ + EL +Q + ++E+ E + L++ Sbjct: 1830 -QGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEV 1888 Query: 2532 IVNLQKIVEEKVAAALVSQIQ-LEAVQEY---AKFCQDNQTISSEPERTNIQNLNQLRED 2587 + +L+ E+ A L Q Q E QE+ + QD+ + + Q L LR + Sbjct: 1889 LGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAE 1948 Query: 2588 ELGS--DISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEK--EKKLLELQKLLE 2643 S A R L+ + + H + L+ ++ + E+ L + E LQ L+ Sbjct: 1949 SQSSRHQEEAARARAEALQEALGKAHAA--LQGKEQHLLEQAELSRSLEASTATLQASLD 2006 Query: 2644 GNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEK 2703 + R+ E+ Q+ E+ +++ + +++ L+ +++A + E ++++ Sbjct: 2007 ACQAHSRQLEEALRIQEGEI---------QDQDLRYQEDVQQLQ-QALAQRDEELRHQQE 2056 Query: 2704 AEKLQEELLVK--ETNMTSLQKDLSQVRD-------HLAEAKEKLSILEKEDE-TEVQES 2753 E+L E+ L + + NM +++L Q R+ H + + +L++ +KE E E++E+ Sbjct: 2057 REQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRET 2116 Query: 2754 KKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTEII 2813 ++ E LP S + + +LK+ S Q ++ LQ+ E EI Sbjct: 2117 QQRNNLEALP--HSHKTSPMEEQSLKLDSLEPRLQRELE------RLQAALRQTEAREI- 2167 Query: 2814 SQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRSK 2873 E EK Q+L L + S + + ++ +L+ + + + ++ Sbjct: 2168 ----EWREKAQDL----ALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTR 2219 Query: 2874 EGSSIPELAHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESES 2926 L A T E+ GS QG+ L G + G E +S Sbjct: 2220 RALEKERLHSPGATSTAEL-----GSRGEQGVQLGEVSGVEAEPSPDGMEKQS 2267 Score = 202 bits (514), Expect = 5e-51 Identities = 465/2369 (19%), Positives = 967/2369 (40%), Gaps = 364/2369 (15%) Query: 164 LAGKQHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDE 223 L K E+E+ E + + ++G + E + + T+L+A L Q++++ ++ Sbjct: 249 LLAKTQELEKEAHERSQELIQLKSQGDLEKAELQDRV-------TELSALLTQSQKQNED 301 Query: 224 TMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHL 283 + L E + L+ +L E + L Q + I Q +EE D++ Sbjct: 302 YEKMIKALRETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDIT--QVMVEEGDNI 359 Query: 284 LE------------------DYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQ 325 + DYQ + T+ S L + + QD + + + Q Sbjct: 360 AQGSGHENSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAV---QDLRQQLAG---CQ 413 Query: 326 EKETIIEELNTKIIEEEKKTLELKDKLT-TADKLLGEL------------QEQIVQKNQE 372 E ++++ + + EE K + KLT D L G+ + +++QK +E Sbjct: 414 EAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKARE 473 Query: 373 IKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQ 432 +LE+ + + QL G + QK ++ Q E + R + Q L Sbjct: 474 ELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQK---EEQQEELHLAVRERERLQEMLMG 530 Query: 433 LRAELDEMYGQQIVQMKQELIRQHMAQ--MEEMKTRHKGEMENALRSYSNITVNEDQIKL 490 L A+ E + ++ +++ L H+ + + +T + A +S + ++ +E+ +K Sbjct: 531 LEAKQSESLSE-LITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKT 589 Query: 491 MNVAINELNIKLQDTNS----QKEKLKEELGLILEEK---CALQRQLEDLVEELSFSREQ 543 + +KL N K L ++L + EE C+ E L + Sbjct: 590 EVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAE 649 Query: 544 IQRARQTIAEQESKLN-EAHKSLSTVEDLKAEIVSASESRKELELK-----HEAEVTNYK 597 ++ R+ + E+ + L + K+ +L+A++ E ++E++ K H+ E + Sbjct: 650 AEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQ 709 Query: 598 IK-LEMLEKEKNAVLDRMAESQEAELER-----LRTQLLFSHEEELSKLKEDLEIEHRIN 651 ++ L K + VL R + +EA + +R Q + ++L++ + L + Sbjct: 710 LEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLS-----S 764 Query: 652 IEKLKDNLGIHYKQQ---IDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQS 708 ++L ++ +QQ I+ + ++ +I+T+ K+ + + L LE+ D ++S Sbjct: 765 AKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLEL----DTERS 820 Query: 709 LVNSKSEEMTLQINELQKEIEILRQE-----EKEKGTLEQE--------VQELQLKTELL 755 + + Q+ + ++E + ++ EKE L ++ QEL E L Sbjct: 821 QAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESL 880 Query: 756 EKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKD 815 E++ E E L+E+ ++EA + ++E+ E L +++ER+ L+++ K+ Sbjct: 881 EREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKE 940 Query: 816 -SVWEKEIEILIEENEDLKQQCIQ-------LNEEIEKQRNTFSFAEKNFEVNYQELQEE 867 + +++E L +D+K Q ++ L ++++ + A + + LQEE Sbjct: 941 LADASQQLERL---RQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEE 997 Query: 868 YACLLKVKDDL--------------EDSKNKQELEYKSKLKALNEELHLQR-INPTTVKM 912 + LL+ K DL +DS+ E E + KL+ E +Q+ + + Sbjct: 998 SSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASL 1057 Query: 913 KSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGE 972 S+ ++++ + E + +++ + L + ++ + E+ ELS ++ L +++K+K E Sbjct: 1058 TLSLMEKEQRLLV-LQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEK--E 1114 Query: 973 ISFLNEEVKSLKQ--------------------EKEQVSLRCR----ELEIIINHNRAEN 1008 FL +E + L++ + Q+ LR R +LE + + N Sbjct: 1115 ADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGN 1174 Query: 1009 VQSCDTQVSSLLDGVVTMTSRGAEGSV--SKVNKSFGEESKIMVEDKVSFENMTVGEESK 1066 Q++SL + + A GSV S+ S G +S V +N G S Sbjct: 1175 QAQAQAQLASLYSAL-----QQALGSVCESRPELSGGGDSAPSVWGLEPDQN---GARSL 1226 Query: 1067 QEQLILDHLPSVTKESSLRATQPSEND--KLQKELNVLKSEQNDLRLQMEAQRICLSLVY 1124 ++ L L +++ E+ A D K Q+ +VL+ + L ++ S V+ Sbjct: 1227 FKRGPL--LTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVH 1284 Query: 1125 STHVDQVREYMENEKDKALC-----SLKEELIFAQEEKIKELQKIHQLELQTMKTQETGD 1179 + D R+ +N+++K+ SL+ EL+ E ++ + ELQ M+ Q G+ Sbjct: 1285 TELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQ--GE 1342 Query: 1180 EGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYIS-ENE 1238 +L +A E + ++ L + + E A + ED + + +NE Sbjct: 1343 R---------ELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNE 1393 Query: 1239 DPELQDYRYEVQDFQENMHTLLNKVTEEYNKLL--VLQTRLSKIWGQQTDGMKLEFGEEN 1296 + E + R + Q + K +E LL L R ++ + +LE + Sbjct: 1394 EVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELE-KQRE 1452 Query: 1297 LPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTK-----LEEQVQELESLISSLQ 1351 + K E LS+ + N +++D+ + +Q+LEK + L VQE E ++ + Sbjct: 1453 MQKAALELLSLDLKKRN-QEVDLQQE----QIQELEKCRSVLEHLPMAVQEREQKLTVQR 1507 Query: 1352 QQLKETEQNYEAEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNID 1411 +Q++E E++ E + + L+ +L + + ++S D ++ + C+ ++ Sbjct: 1508 EQIRELEKDRETQRNVLEHQLLELEKK----DQMIESQRGQVQDLKKQLVTLECLALELE 1563 Query: 1412 GTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENT 1471 ++ + ++K LE Q + Q VA +++ + Q E Sbjct: 1564 -----ENHHKMECQQKLIKELEGQRETQ---RVALTHLTLDLEERSQ----------ELQ 1605 Query: 1472 ASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLS 1531 A S Q H + E++ ++ Q + +++ ++E L+++L +E++L Sbjct: 1606 AQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEH--LTQDLERRDQELML- 1662 Query: 1532 NSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMR 1591 K+ + + ++ + K I+ + + ++I +S + R+L + +++ Sbjct: 1663 ---------QKERIQVLEDQRTRQTK--ILEEDL-EQIKLSLRERGRELTTQRQLMQERA 1710 Query: 1592 QE------LVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQL--AQRSSI 1643 +E R EH +L+ + +++E Q+E +LQE +L +QL R Sbjct: 1711 EEGKGPSKAQRGSLEHM---KLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVG 1767 Query: 1644 DNENLVSERER---VLLEELEALKQLSLAGREKLCCEL---------RNSSTQTQNGNEN 1691 + L+S+RE+ VL ++L+ ++ + L +L R+ + + Sbjct: 1768 ETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQ 1827 Query: 1692 QGEVEEQTFKEKELDRKPEDVPPEILSNERYA-LQKANNRLLKILLEVV---KTTAAVEE 1747 Q + +E+ KEK + + ER+ LQ + ++ E+ + A+EE Sbjct: 1828 QAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEE 1887 Query: 1748 TIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRND 1807 VLG L S+ Q A L + + + HE TR +S Sbjct: 1888 -----VLGDLRAESREQEKALLALQQQCAEQAQE--HEVETRALQDS------------- 1927 Query: 1808 INMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQ 1867 W + E Q L + L A S++S Sbjct: 1928 ---WLQAQAVLKERDQEL------------------------------EALRAESQSSRH 1954 Query: 1868 LEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGY 1927 E A + E ++E+ + A + + + L E++ +L+ L + + Sbjct: 1955 QEEAARARAEALQEALGKAHAALQGKE------QHLLEQA----ELSRSLEASTATLQAS 2004 Query: 1928 ADEKTLFERQIQEKTDIIDR--LEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKA 1985 D RQ++E I + +Q+L + Q +A Q+ +E R R++ K+ Sbjct: 2005 LDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKS 2064 Query: 1986 EAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDV---EEQVSRFIELEQ 2042 A V++ ++QE + L +E+ E E++R L + V+ L++ + E+++ E +Q Sbjct: 2065 LAQRVQENMIQEKQNLGQEREE-----EEIR-GLHQSVRELQLTLAQKEQEILELRETQQ 2118 Query: 2043 EKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQP 2102 N E + + +E+Q K+ D + +Q+ ++L+ R Sbjct: 2119 RNNLEALPHSHKTSPMEEQSLKL---------------DSLEPRLQRELERLQAALRQTE 2163 Query: 2103 ISEHQTRE-VEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALL 2161 E + RE + LA L + S L LQ + ER+ E ++L+ + EL + L Sbjct: 2164 AREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDEL-ELTRRAL 2222 Query: 2162 VEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQL 2221 ++R H + EL + + + E E + + + +R+ LE+ + V +L Sbjct: 2223 EKERLHSPGATSTAELGSRGEQGVQLGEVSGVEAEPSPDGMEKQSWRQRLEHLQQAVARL 2282 Query: 2222 HM---QLEIQKKESTTRLQELEQENKLFKDDMEKL----GLAIKESDAMS--TQDQHVLF 2272 + +L+ + + L+++E+E + K + + L I ++ A S QD Sbjct: 2283 EIDRSRLQRHNVQLRSTLEQVERERRKLKREAMRAAQAGSLEISKATASSPTQQDGRGQK 2342 Query: 2273 GKFAQIIQEKEVEIDQLNEQVT--KLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQ 2330 A+ + E + E+ L Q+T + Q+Q IT + E L L + + Sbjct: 2343 NSDAKCVAELQKEVVLLQAQLTLERKQKQDYITRSAQTSRELAGLHHSLSHSLLAVAQAP 2402 Query: 2331 ECVKRNREEEIEQLNEVIEKLQQELANIG 2359 E E E +L+ E L Q L + G Sbjct: 2403 EATV--LEAETRRLD---ESLTQSLTSPG 2426 Score = 195 bits (495), Expect = 8e-49 Identities = 490/2344 (20%), Positives = 937/2344 (39%), Gaps = 389/2344 (16%) Query: 1324 KLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSESTVPPS 1383 +L S DLEK +L+++V EL +L++ Q+Q ++YE I L+ Sbjct: 269 QLKSQGDLEKAELQDRVTELSALLTQSQKQ----NEDYEKMIKALR-------------- 310 Query: 1384 LPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEE 1443 ++V I E++ M + + +N EK +Q+ ++ Sbjct: 311 ---ETVEILETNHTELMEHEASLSRNAQE--------------------EKLSLQQVIKD 347 Query: 1444 VAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTF 1503 + +V+V AQ G EN+ + + F++ Sbjct: 348 ITQVMVEEGDNIAQ-------GSGHENSL---------ELDSSIFSQFDYQDADKALTLV 391 Query: 1504 ETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQ 1563 +V + ++ + L ++L + + L HD E + L + + ++ + Q Sbjct: 392 RSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQ-HDQWEEEGKALRQRLQKLTGERDTLAGQ 450 Query: 1564 SIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQE----HQQATELLRQAHMRQMERQ 1619 ++ + V S+ R+L+ ++ E++RQ+L QE + EL Q Q +++ Sbjct: 451 TVDLQGEVDSLSKERELL--QKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKE 508 Query: 1620 REDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELR 1679 E QE+L ++ R+ Q + E SE L+ EAL+ L G E L E Sbjct: 509 -EQQEELHLAVRE--RERLQEMLMGLEAKQSESLSELITLREALESSHLEG-ELLRQEQT 564 Query: 1680 NSSTQTQNGNENQGEVE--EQTFKEKELDRKPEDVPPEILSNERYALQKA--NNRLLKIL 1735 + ++ E+ E T K + D + V L NE AL K N +LL++ Sbjct: 565 EVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSAL-NEALALDKVGLNQQLLQLE 623 Query: 1736 LE---VVKTTAAVEETIGRHVLGILDRSSKSQS--------SASLIWRSEAEASVKSCVH 1784 E V A E+ + + + + ++ A L EA A +++ + Sbjct: 624 EENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLR 683 Query: 1785 ------EEHTRVTDESIPSYSGSDMPRNDINMWSKVTEE----GTELSQRLVRSGFAGT- 1833 EE + ES + ++ +K EE + + LVR A Sbjct: 684 DIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEV 743 Query: 1834 ---EIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVT--QTELMRESFRQKQE 1888 ++ + ++L + L +A E L ++ E Q +VT Q E+ ++ Q +E Sbjct: 744 RLQAVERDRQDLAEQLQG-LSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKE 802 Query: 1889 ATES-LKCQE-ELRERLHEESRAREQLAVELSKAEGV-IDGYADEKTLFERQI------- 1938 + ++C + EL + + R+ A +L++AE +K E+++ Sbjct: 803 VIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKW 862 Query: 1939 --------QEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPV 1990 QE ++ LE+E + RL+E + E + IQ +RE +E +AE+ Sbjct: 863 EKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQRE-----EERTQAESALC 917 Query: 1991 EQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMD 2050 + QL ETEK LE Q +K D +Q++ L D++ Q + E T+L + Sbjct: 918 QMQL--ETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQE 975 Query: 2051 LRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISE----- 2105 +++ + +Q L E++ ++ Q++++ L+ QL Q + E Sbjct: 976 AQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQE 1035 Query: 2106 --HQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVE 2163 +T+E ++ L+ + + L+ KEQ +QE + +R+ E + L + Sbjct: 1036 KLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADS--------IRQQELSALRQ 1087 Query: 2164 DRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLH- 2222 D + A + ELS +++L + + KEKE L ++ Q EELE + QQL Sbjct: 1088 DMQE--AQGEQKELSAQMELLRQ----EVKEKEADFLAQE-AQLLEELEASHITEQQLRA 1140 Query: 2223 ---------MQLEIQKKESTTRLQELEQENK-------------LFKDDMEKLGLAIKES 2260 QL+++ + + ++L+ L E + L+ + LG + Sbjct: 1141 SLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESR 1200 Query: 2261 DAMS------------TQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKV 2308 +S DQ+ F + + + + + KL Q L T Sbjct: 1201 PELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKT----- 1255 Query: 2309 IEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELAN-IGQKTSMNAH 2367 ++ +++RD ++E ++D E K E++ L + + Q+E + G++ S+ + Sbjct: 1256 -QQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESE 1314 Query: 2368 --SLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSL 2425 L E SL+ +L + A Q++E E + +L+ + + L + Sbjct: 1315 LMELHETMASLQSRL------RRAELQRMEAQGE-----RELLQAAKENLTAQVEHLQAA 1363 Query: 2426 KRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGS 2485 E + I E + A L E+E + ++L+ Q K + GK Sbjct: 1364 VVEARAQASAAGILEEDLRTARSALKLKNEEVE--SERERAQALQEQGELKVAQ--GKA- 1418 Query: 2486 IINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAA 2545 L+ L L T++ ++ E+ QI+++++Q + + L+ ++L+K +E Sbjct: 1419 ---LQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQE---- 1471 Query: 2546 ALVSQIQLEAVQEYAKFCQD-----NQTISSEPERTNIQNLNQLREDELGSDISALTLRI 2600 +Q E +QE K C+ + ++ +Q Q+RE E + Sbjct: 1472 ---VDLQQEQIQELEK-CRSVLEHLPMAVQEREQKLTVQR-EQIRELEKDRETQR----- 1521 Query: 2601 SELESQVVEMHTS---LILEKEQVEIAEKNVLEKEKKLLELQK---LLEGNEKKQREKEK 2654 + LE Q++E+ + ++ QV+ +K ++ E LEL++ +E +K +E E Sbjct: 1522 NVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEG 1581 Query: 2655 KRSPQDVEVLKTTTELFHSNEE-SGFFNELEALRAESVATKAELASYKEKAEKLQEELLV 2713 +R Q V + T +L ++E +++ L + S EL ++ + +E++ Sbjct: 1582 QRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEE 1641 Query: 2714 KETNMTSLQKDLSQVRDHLAEAKEKLSILE--KEDETEVQESKKACMFEPLPIKL---SK 2768 + L +DL + L KE++ +LE + +T++ E E + + L + Sbjct: 1642 LQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEED----LEQIKLSLRERGR 1697 Query: 2769 SIASQTDGTLKISSSNQTPQILVKNAGIQINL-------QSECSSEEVTEIISQFTEKIE 2821 + +Q + + + P + + + L + EC E + E+ + + Sbjct: 1698 ELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQ 1757 Query: 2822 KMQELHAAEILDMESRHISETETL--KREHYVAV--QLLKE--ECGTLKAVIQCLRSKEG 2875 ++Q LH R + ET L +RE + V Q L+E E G LK Q L+S+ Sbjct: 1758 QLQGLH---------RKVGETSLLLSQREQEIVVLQQQLQEAREQGELKE--QSLQSQLD 1806 Query: 2876 SSIPELAHSDAYQTREICSSDSGSDWGQ----------------GIYLT----HSQGFDI 2915 + LA D Q E + GQ ++T H + D Sbjct: 1807 EAQRALAQRD--QELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDH 1864 Query: 2916 ASEGRGEESESATD----SFPKKIKGLLRAVHNEGMQ-VLSLTESPYSDGEDHSIQ--QV 2968 + R E E A + +++ G LRA E + +L+L + ++H ++ + Sbjct: 1865 KEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRAL 1924 Query: 2969 SEPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQ---QV 3025 + WL+ + L+ L + Q R E +++ E+ + G+ ALQ Q Sbjct: 1925 QDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARA-EALQEALGKAHAALQGKEQH 1983 Query: 3026 FLEERSVLLAAFRTELTALGTTDAV--------GLLNCLEQRIQEQGVEYQAAMECLQKA 3077 LE+ + + + T + DA L E IQ+Q + YQ ++ LQ+A Sbjct: 1984 LLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQA 2043 Query: 3078 DRRSLLSEIQALHAQMNGRKITLKREQESEKP-SQELLEYNIQQKQSQMLEM-QVELSSM 3135 L + L Q +REQ EK +Q + E IQ+KQ+ E + E+ + Sbjct: 2044 ----LAQRDEELRHQQ-------EREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGL 2092 Query: 3136 KDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHK-HLKELEAFRLEVKDKTDE 3194 ELQ L+ ++ + EL+ + LE L HK E ++ +L+ + + Sbjct: 2093 HQSVRELQLTLAQKEQEILELRETQQRNNLE---ALPHSHKTSPMEEQSLKLDSLEPRLQ 2149 Query: 3195 VHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQ--RNLQLN 3252 L A Q ++RE++W +E+ +DL SL K +LQ Sbjct: 2150 RELERLQAALRQTEAREIEW----------------REKAQDLALSLAQTKASVSSLQEV 2193 Query: 3253 LLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRER 3312 + Q L +S+Q QR+ + +L+ LE E++ +ST + Sbjct: 2194 AMFLQASVLERDSEQ----QRLQDELELTRR---------ALEKERLHSPGATSTAELGS 2240 Query: 3313 ELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTR--- 3369 +Q + +G P P + +++LE + L + + + ++Q R Sbjct: 2241 RGEQGVQLGEVSGVEAEPSPDGMEKQSWRQRLEHLQQAVARLEIDRSRLQRHNVQLRSTL 2300 Query: 3370 QQMEKDR----------------QVHRKTLQTEQEANTEGQKK-----MHELQSKVEDLQ 3408 +Q+E++R ++ + T + + + GQK + ELQ +V LQ Sbjct: 2301 EQVERERRKLKREAMRAAQAGSLEISKATASSPTQQDGRGQKNSDAKCVAELQKEVVLLQ 2360 Query: 3409 RQ--LEEKRQQVY--KLDLEGQRLQGIMQEFQKQELEREEKRESRRILYQ--NLNEPTTW 3462 Q LE K++Q Y + + L G+ L + E+ + + L+E T Sbjct: 2361 AQLTLERKQKQDYITRSAQTSRELAGLHHSLSHSLLAVAQAPEATVLEAETRRLDESLTQ 2420 Query: 3463 SLTS 3466 SLTS Sbjct: 2421 SLTS 2424 Score = 176 bits (447), Expect = 3e-43 Identities = 397/1947 (20%), Positives = 803/1947 (41%), Gaps = 293/1947 (15%) Query: 1811 WSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEH 1870 W + E+ E + + + E +P +EL++ + Q E+++E ++QL Sbjct: 69 WCQELEKRLEATGGPIPQRWENVE-EPNLDELLVRLEEEQQRC-----ESLAEVNTQLR- 121 Query: 1871 AKVTQTELMRESFRQKQE--ATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYA 1928 + + +++ ++ R+ E + + ++EL + + +E L G + Sbjct: 122 LHMEKADVVNKALREDVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLLSLW 181 Query: 1929 DEKTLFERQIQEKTDIIDRLEQELLCASNRL---------------QELEAEQQQIQEER 1973 E F R E DR EL RL Q E + R Sbjct: 182 REVVTFRRHFLEMKSATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGR 241 Query: 1974 E-----LLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQ----------CQAEKVRDD 2018 E LL + + ++ EA Q+L+Q + EK E+Q Q++K +D Sbjct: 242 EPAQLLLLLAKTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNED 301 Query: 2019 LQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAID--- 2075 +K +KAL VE + EL + + + + +++ +L++ ++ + + + E+ + Sbjct: 302 YEKMIKALRETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQ 361 Query: 2076 -------REHERDVF----------------------QQEIQKLEQQL----KVVPRFQP 2102 E + +F +Q +Q L QQL + V Q Sbjct: 362 GSGHENSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQ 421 Query: 2103 ISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLV 2162 + E + L L++ T + L LQ ++ ++E E L+ EL Q L V Sbjct: 422 QHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEV 481 Query: 2163 EDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLH 2222 ++ EA + V+LQ + D+ ++ EEQ E+ + + E +Q++ Sbjct: 482 LEQ------EAWRLRRVNVELQLQGDSAQGQK------EEQQEELHLAVRER-ERLQEML 528 Query: 2223 MQLEIQKKESTTRLQELEQ-------ENKLFKDDMEKLGLAI---KESDAMSTQDQHVLF 2272 M LE ++ ES + L L + E +L + + ++ A+ ++S A + ++ L Sbjct: 529 MGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLK 588 Query: 2273 GKFAQIIQEKEVEIDQLNE-----QVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLM 2327 + A + + V++ LNE +V QQ L++ +N+ + + E ++ + Sbjct: 589 TEVADL-RAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDL 647 Query: 2328 SDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEK 2387 ++ E R E + + N +E Q+ G + + + EE + ++ +L ++ Sbjct: 648 AEAE----KRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQ 703 Query: 2388 LALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVE-KIQSIPENSVNVA 2446 A Q+E ++E + VL QE +L RE+ ++E ++Q++ + ++A Sbjct: 704 EAATTQLEQLHQEAKRQEEVLARA-------VQEKEALVREKAALEVRLQAVERDRQDLA 756 Query: 2447 --IDHLSKDKPELEVVLTE-----DALKSLENQTYFKSFEENGKGSIINLETRLLQLEST 2499 + LS K LE L E ++ + Q + +I E R L+LE Sbjct: 757 EQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLEL- 815 Query: 2500 VSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAV--- 2556 D E +Q +Q +D + + E K + QK EK L + + E Sbjct: 816 ----DTERSQA-EQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQ 870 Query: 2557 QEYAKFCQDNQTISSEPE------RTNIQNLNQLREDELGSDISALTLRISELESQVVEM 2610 QE AK + + E E +T ++ + RE+E SAL E E + V + Sbjct: 871 QELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSL 930 Query: 2611 HTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTEL 2670 +L+ ++++ A + LE+ ++ +++QKL K++E Q E + E Sbjct: 931 LETLLQTQKELADASQQ-LERLRQDMKVQKL------KEQETTGILQTQLQEAQRELKEA 983 Query: 2671 FHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRD 2730 + + +L AL+ ES + + +++ E L+ +L+ ++ + ++++ V++ Sbjct: 984 ARQHRD-----DLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQE---VQE 1035 Query: 2731 HLAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQIL 2790 L E +E + ++KE E E KA + L K + + Q +++ + Q + Sbjct: 1036 KLRETQE-YNRIQKELERE-----KASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDM 1089 Query: 2791 VKNAGIQ--INLQSECSSEEVTEIISQFTEKIEKMQELHAAEILDMESRHISETETLKRE 2848 + G Q ++ Q E +EV E + F + ++ E ++E+ HI+E + Sbjct: 1090 QEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLE-------ELEASHITEQQ----- 1137 Query: 2849 HYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREICSSDSGSDWGQGIYLT 2908 + L +E + ++ LRS E S + LA + + S +Y Sbjct: 1138 --LRASLWAQEAKAAQLQLR-LRSTE-SQLEALAAEQQPGNQAQAQAQLAS-----LYSA 1188 Query: 2909 HSQGFDIASEGRGEESESATDSFPKKIKGL------LRAVHNEGMQVLSLTESPYSDGED 2962 Q E R E S DS P + GL R++ G + +L+ + Sbjct: 1189 LQQALGSVCESRPELSGGG-DSAPS-VWGLEPDQNGARSLFKRGPLLTALSAEAVASAL- 1245 Query: 2963 HSIQQVSEPWLEERKAYINTISSLKDLITKMQLQRE---AEVYDS----SQSHESFSDWR 3015 H + Q + R + + L++ +T + ++ E+ D SQ+ E S W Sbjct: 1246 HKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWE 1305 Query: 3016 GEL------LLALQQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQA 3069 G+ L+ L + +S L A + A G + LL ++ + Q QA Sbjct: 1306 GKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERE---LLQAAKENLTAQVEHLQA 1362 Query: 3070 AM-ECLQKADRRSLLSE-IQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQS---- 3123 A+ E +A +L E ++ + + + ++ E+E + QE E + Q ++ Sbjct: 1363 AVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQEN 1422 Query: 3124 ------QMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKH 3177 + E + E+ +++ + EL++Q +K + L +L + E++ Q + Sbjct: 1423 LALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDL----QQEQ 1478 Query: 3178 LKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQW-------ALEKEKAKLGRSE--- 3227 ++ELE R ++ V L ++++ REL+ LE + +L + + Sbjct: 1479 IQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMI 1538 Query: 3228 ERDKEELEDLKFSLESQKQRNLQL---NLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQ 3284 E + +++DLK L + + L+L + +E Q++L+ E + + E+QR+ + + Sbjct: 1539 ESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLE 1598 Query: 3285 GRNLELQVLLESEKVRIREMSSTL------DRERELHAQLQSSDGTGQSRPPLPSE---- 3334 R+ ELQ +S ++ E ST+ +R++E+ +Q + + + + L + Sbjct: 1599 ERSQELQA--QSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERR 1656 Query: 3335 ----DLLKELQKQLEEKHSRIVELLNET-EKYKLDSLQTRQQMEKDRQV----------- 3378 L KE + LE++ +R ++L E E+ KL + +++ RQ+ Sbjct: 1657 DQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGP 1716 Query: 3379 ---------HRKTLQTEQEANTEGQKK-MHELQSKVEDLQRQLEEKRQQVYKLD-LEGQR 3427 H K + ++E E Q++ +HELQ + L++QL+ ++V + L QR Sbjct: 1717 SKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQR 1776 Query: 3428 LQGIMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNY 3487 Q I+ Q+ + RE+ + L L+E D+ + Q++ + + +E Sbjct: 1777 EQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERV 1836 Query: 3488 AKLIEMNGGGTGCNHELEMIRQKLQCVASKLQVLPQKASERLQFETADDEDFIWVQENI- 3546 + + G LE L+ +LQ ++A RL+ E A + + E + Sbjct: 1837 KEKADALQGA------LEQAHMTLKERHGELQDHKEQA-RRLEEELAVEGRRVQALEEVL 1889 Query: 3547 ----------DEIILQLQKLTGQQGEE 3563 ++ +L LQ+ +Q +E Sbjct: 1890 GDLRAESREQEKALLALQQQCAEQAQE 1916 Score = 145 bits (366), Expect = 8e-34 Identities = 280/1392 (20%), Positives = 590/1392 (42%), Gaps = 194/1392 (13%) Query: 158 EMMESELAGKQHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQA 217 E E E + Q E+ + LE ++ +Q E EA QR+ TQ + L Q Sbjct: 860 EKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQM 919 Query: 218 RREKDETMREFL--------ELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQ 269 + E ++ L EL + SQ+L+ Q ++ + T L +A+++ Sbjct: 920 QLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRE 979 Query: 270 I----LTHQQQL----EEQDHLLE---DYQKKKEDFTMQISFLQEKIKVYEMEQDKKVEN 318 + H+ L EE LL+ D QK+ ED Q+ + ++ E E +K+ Sbjct: 980 LKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRE 1039 Query: 319 SNKEEIQEKETIIEE--LNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNM 376 + + +KE E+ L ++E+E++ L L++ + + L L++ + + E K + Sbjct: 1040 TQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKEL 1099 Query: 377 --KLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDI---------VQRMEQE 425 ++EL + KE++ ++ + Q +EEL+ + + Q + +Q + Sbjct: 1100 SAQMELLRQEVKEKE-ADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRS 1158 Query: 426 TQRKLEQLRAEL---DEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNIT 482 T+ +LE L AE ++ Q + ++Q + + E + G ++A + Sbjct: 1159 TESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWG--- 1215 Query: 483 VNEDQ-----------------IKLMNVAINELNIKLQDT-------NSQKEKLKEELGL 518 + DQ + + A+++L+ L T Q +KL+E L Sbjct: 1216 LEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTD 1275 Query: 519 ILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVED-LKAEIVS 577 EK + +L+DL +LS ++E+ + ES+L E H+++++++ L+ + Sbjct: 1276 TEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQ 1335 Query: 578 ASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQ-----EAELERLRTQLLFS 632 E++ E EL A+ N ++E L+ AV++ A++ E +L R+ L Sbjct: 1336 RMEAQGERELLQAAK-ENLTAQVEHLQA---AVVEARAQASAAGILEEDLRTARSALKLK 1391 Query: 633 HEEELSKLKEDLEIEHRINI-----EKLKDNLGI------HYKQQIDGLQNEMSQKIETM 681 +EE S+ + ++ + + + L++NL + +++++ L+ ++ + + Sbjct: 1392 NEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQR 1451 Query: 682 QFEKDNL-------------ITKQNQLILEISKLKDLQQSL---VNSKSEEMTLQINELQ 725 + +K L + Q + I E+ K + + + L V + +++T+Q +++ Sbjct: 1452 EMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIR 1511 Query: 726 KEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKEN-------------DLQEKFAQ 772 E+ + E ++ LE ++ EL+ K +++E Q + ++ +L+E + Sbjct: 1512 ---ELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHK 1568 Query: 773 LEAENSILK--DEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENE 830 +E + ++K + ++ + + H + EER L + S+ D E +L E + Sbjct: 1569 MECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHD--LESHSTVLARELQ 1626 Query: 831 DLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQE--LQEEYACLLKVKDDLEDSKNKQELE 888 + Q+ E+IE+ + ++ E QE LQ+E +L+ + + +++LE Sbjct: 1627 ERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLE 1686 Query: 889 -YKSKLKALNEELHLQR--------INPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTT 939 K L+ EL QR K + + K + + + E ++ Sbjct: 1687 QIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIH 1746 Query: 940 ELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEI 999 EL E + +++ L +++ + S L Q+ EI L ++ L++ +EQ L+ + L+ Sbjct: 1747 ELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQ---LQEAREQGELKEQSLQ- 1802 Query: 1000 IINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENM 1059 ++ + Q Q L+ + + A+G +V +E ++ + +M Sbjct: 1803 ----SQLDEAQRALAQRDQELE-ALQQEQQQAQGQEERV-----KEKADALQGALEQAHM 1852 Query: 1060 TVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRIC 1119 T+ E + Q DH KE + R + E + + L+ DLR + Q Sbjct: 1853 TLKERHGELQ---DH-----KEQARRLEE--ELAVEGRRVQALEEVLGDLRAESREQEKA 1902 Query: 1120 LSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQ---EEKIKELQKIHQLELQTMKTQE 1176 L + +Q +E+ + +L++ + AQ +E+ +EL+ + + E Q+ + QE Sbjct: 1903 LLALQQQCAEQAQEHEVETR-----ALQDSWLQAQAVLKERDQELEAL-RAESQSSRHQE 1956 Query: 1177 TGDEGK--PLHLLIGKLQKAVSEECSYFL-QTLCSVLGEYYTPALKCEVNA-EDKENSGD 1232 + L +GK A+ + + L Q S E T L+ ++A + + Sbjct: 1957 EAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLE 2016 Query: 1233 YISENEDPELQD----YRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGM 1288 ++ E+QD Y+ +VQ Q+ + ++ + + +L+ L++ + Sbjct: 2017 EALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQE 2076 Query: 1289 KLEFGEE------------------NLPKEETEFLSIH--SQMTNLEDIDVNHKSKLSSL 1328 K G+E L ++E E L + Q NLE + +HK+ Sbjct: 2077 KQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEE 2136 Query: 1329 QDLEKTKLEEQVQ-ELESLISSLQQ-QLKETEQNYEAEIHCLQKRLQAVSESTVPPSLPV 1386 Q L+ LE ++Q ELE L ++L+Q + +E E +A+ L S S++ Sbjct: 2137 QSLKLDSLEPRLQRELERLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMF 2196 Query: 1387 DSVVITESDAQR 1398 + E D+++ Sbjct: 2197 LQASVLERDSEQ 2208 Score = 139 bits (349), Expect = 7e-32 Identities = 182/914 (19%), Positives = 400/914 (43%), Gaps = 91/914 (9%) Query: 126 RTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHEIEELNRELEEMRVTY 185 +T + ++LR++ +++ ++ A+ S H E+ + + +L++ EE Sbjct: 1254 KTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQ--------RQLSQNQEEKSKWE 1305 Query: 186 GTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQIQFQQL 245 G + E+ + + + L + L++A ++ E E L + L Q + L Sbjct: 1306 GKQ-----NSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHL 1360 Query: 246 QASETLRNSTHSSTA---ADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQ 302 QA+ + S+ DL A+ + +++E + + Q++ E Q LQ Sbjct: 1361 QAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQ 1420 Query: 303 EKIKVYEM---EQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLL 359 E + + E++++VE + + +IQE E E + E +L+LK + D Sbjct: 1421 ENLALLTQTLAEREEEVE-TLRGQIQELEKQREMQKAAL---ELLSLDLKKRNQEVDLQQ 1476 Query: 360 GELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIV 419 ++QE + + ++++ + + +QK E+I++L KD + + +++ Sbjct: 1477 EQIQE-LEKCRSVLEHLPMAVQEREQKLTVQREQIREL-----------EKDRETQRNVL 1524 Query: 420 QRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYS 479 + E ++K + + ++ Q+ +K++L+ +E + HK E + L Sbjct: 1525 EHQLLELEKKDQMIESQRG-----QVQDLKKQLVTLECLALELEENHHKMECQQKL---- 1575 Query: 480 NITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSF 539 I E Q + VA+ L + L++ + + + ++ + L R+L++ +E+ Sbjct: 1576 -IKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKS 1634 Query: 540 SREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIK 599 REQI+ ++ L + L ++ + +++ +R+ L+ + E +IK Sbjct: 1635 QREQIEELQRQKEHLTQDLERRDQELMLQKE-RIQVLEDQRTRQTKILEEDLE----QIK 1689 Query: 600 LEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLE------IEHRINIE 653 L + E+ + R + AE + ++ E + + D E EH ++ Sbjct: 1690 LSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQ 1749 Query: 654 KLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSK 713 +LKD L +QQ+ GL ++ + + + ++ Q QL E + +L++ + S+ Sbjct: 1750 ELKDQL----EQQLQGLHRKVGETSLLLSQREQEIVVLQQQL-QEAREQGELKEQSLQSQ 1804 Query: 714 SEEMTLQINELQKEIEILRQEEKEKGTLEQEVQE----LQLKTELLEKQMKEKENDLQ-- 767 +E + + +E+E L+QE+++ E+ V+E LQ E +KE+ +LQ Sbjct: 1805 LDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDH 1864 Query: 768 -EKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILI 826 E+ +LE E ++ + LE++L S+E+ L +++ + + E E+E Sbjct: 1865 KEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALL-ALQQQCAEQAQEHEVETRA 1923 Query: 827 EENEDLKQQCI---------QLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLL-KVKD 876 ++ L+ Q + L E + R+ A E + L + +A L K + Sbjct: 1924 LQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQH 1983 Query: 877 DLEDSKNKQELEYK-SKLKALNE--ELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEV 933 LE ++ + LE + L+A + + H +++ + + D+D + + ++ + Sbjct: 1984 LLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQA 2043 Query: 934 VEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHG------EISFLNEEVKSLK--- 984 + + EL + E + + L+QR+ + Q KQ G EI L++ V+ L+ Sbjct: 2044 LAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTL 2103 Query: 985 QEKEQVSLRCRELE 998 +KEQ L RE + Sbjct: 2104 AQKEQEILELRETQ 2117 Score = 61.2 bits (147), Expect = 2e-08 Identities = 129/644 (20%), Positives = 261/644 (40%), Gaps = 70/644 (10%) Query: 4 EERQKKLEAGKAKLAQFRQRKAQSDGQSPSKKQKKKRKTSSSKHDVSAHHDLNIDQSQCN 63 +E Q+ L +L +Q + Q+ GQ K+K + + AH L + Sbjct: 1806 DEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALE---QAHMTLKERHGELQ 1862 Query: 64 EMYINSSQRVESTVIPESTIMRTLHSGEITSHEQGFSVELESEISTTADDCSSEVNGCSF 123 + + ++R+E + E ++ L E+ + S E E + C+ + Sbjct: 1863 D-HKEQARRLEEELAVEGRRVQALE--EVLGDLRAESREQEKALLALQQQCAEQAQEHEV 1919 Query: 124 VMRTGKPTNLLREEEFGVDDSYSEQGA--QDSPTHLEMMESELAGKQHEIEELNRELEEM 181 R + DS+ + A ++ LE + +E +H+ E E + Sbjct: 1920 ETR-------------ALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEAL 1966 Query: 182 RVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQIQ 241 + G + LQ E + ++ + L A+ + D +L E L+IQ Sbjct: 1967 QEALG-KAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEE---ALRIQ 2022 Query: 242 FQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFL 301 ++Q + LR L + + L HQQ E++ LLE ++ +Q + + Sbjct: 2023 EGEIQ-DQDLRYQEDVQQLQQALAQRDEELRHQQ---EREQLLEKSLAQR----VQENMI 2074 Query: 302 QEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGE 361 QEK + Q+++ +EEI+ + EL + ++E++ LEL++ T L Sbjct: 2075 QEK---QNLGQERE-----EEEIRGLHQSVRELQLTLAQKEQEILELRE--TQQRNNLEA 2124 Query: 362 LQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQR 421 L E +++KL+ E + E+++L + + + R + + D+ Sbjct: 2125 LPHSHKTSPMEEQSLKLD-----SLEPRLQRELERLQAALRQTEAREIEWREKAQDLALS 2179 Query: 422 MEQETQRKLEQLR--------AELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMEN 473 + Q T+ + L+ + L+ QQ +Q + EL R+ +E+ + G Sbjct: 2180 LAQ-TKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRR---ALEKERLHSPGATST 2235 Query: 474 A-LRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQR---Q 529 A L S V ++ + + ++ Q + E L++ + + ++ LQR Q Sbjct: 2236 AELGSRGEQGVQLGEVSGVEAEPSPDGMEKQSWRQRLEHLQQAVARLEIDRSRLQRHNVQ 2295 Query: 530 LEDLVEELSFSREQIQRARQTIAEQES-KLNEAHKSLSTVEDLKAEIVSASESRKELELK 588 L +E++ R +++R A+ S ++++A S T +D + + S ++ EL Sbjct: 2296 LRSTLEQVERERRKLKREAMRAAQAGSLEISKATASSPTQQDGRGQKNSDAKCVAEL--- 2352 Query: 589 HEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFS 632 + EV + +L + K+K + R A++ EL L L S Sbjct: 2353 -QKEVVLLQAQLTLERKQKQDYITRSAQTSR-ELAGLHHSLSHS 2394 Score = 59.7 bits (143), Expect = 6e-08 Identities = 137/677 (20%), Positives = 273/677 (40%), Gaps = 93/677 (13%) Query: 3074 LQKAD--RRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVE 3131 ++KAD ++L +++ L + + L R++ + QE + ++ + ++L + E Sbjct: 124 MEKADVVNKALREDVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLLSLWRE 183 Query: 3132 LSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELET-----TLKAQHKHLKELEAFRL 3186 + + + E++ + M ELK+E + L T T+ AQ + + R+ Sbjct: 184 VVTFRRHFLEMKSATDRDLM---ELKAEHVRLSGSLLTCCLRLTVGAQSREPNG--SGRM 238 Query: 3187 EVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQ 3246 + ++ + LL T E++ Q E +L + +K EL+D L + Sbjct: 239 DGREPAQLLLLLAKTQELEKEAHERSQ-----ELIQLKSQGDLEKAELQDRVTELSALLT 293 Query: 3247 RNLQLNLLLEQQKQLLNESQQKIESQR---MLYDAQLSEE-QGRNLELQ-VLLESEKVRI 3301 ++ + N E+ + L E+ + +E+ M ++A LS Q L LQ V+ + +V + Sbjct: 294 QSQKQNEDYEKMIKALRETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMV 353 Query: 3302 RE---------MSSTLDRERELHAQLQSSDG----TGQSRPPLPSEDLLKELQKQLEEKH 3348 E ++L+ + + +Q D T +++L++QL Sbjct: 354 EEGDNIAQGSGHENSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQ 413 Query: 3349 SRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQ 3408 + L + ++++ + RQ+++K R TL + + Q ++ L + E LQ Sbjct: 414 EAVNLLQQQHDQWEEEGKALRQRLQK-LTGERDTLAGQ---TVDLQGEVDSLSKERELLQ 469 Query: 3409 RQLEEKRQQVYKLDLEGQRLQGIMQEFQKQ-ELEREEKRESRRILYQNLNEPTTWSLTSD 3467 + EE RQQ+ L+ E RL+ + E Q Q + + +K E + L+ + E Sbjct: 470 KAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRE--------- 520 Query: 3468 RTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMIRQKLQCVASKLQVLPQKASE 3527 R R + +E + ES ++LI + + E E++RQ+ V + L Q +E Sbjct: 521 RERLQEMLMGLEAKQSES-LSELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAE 579 Query: 3528 ------RLQFETAD-----------DEDFIWVQENIDEIILQLQK--------------- 3555 L+ E AD +E + +++ +LQL++ Sbjct: 580 LSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQA 639 Query: 3556 -------LTGQQGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKL 3608 L + +L +T + ++ AEL + + EEK +++ KL Sbjct: 640 RNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQK---KL 696 Query: 3609 EEQIRWYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRAEAEVYKL 3668 E R ++ + + A EKE REK L+ L+ E + L Sbjct: 697 SES-RHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDL 755 Query: 3669 KAELRNDSLLQTLSPDS 3685 +L+ S + L S Sbjct: 756 AEQLQGLSSAKELLESS 772 Score = 51.6 bits (122), Expect = 2e-05 Identities = 128/681 (18%), Positives = 271/681 (39%), Gaps = 130/681 (19%) Query: 3111 QELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKL---EL 3167 Q +LE + Q QM E Q + E Q++ ++ +V +L++++ Q + EL Sbjct: 17 QLVLEEQVLALQQQMAENQAASWRKLKNSQEAQQRQAT---LVRKLQAKVLQYRSWCQEL 73 Query: 3168 ETTLKA------------QHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWA 3215 E L+A + +L EL E + + + + +N L +K+ + A Sbjct: 74 EKRLEATGGPIPQRWENVEEPNLDELLVRLEEEQQRCESLAEVNTQLRLHMEKADVVNKA 133 Query: 3216 LEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRML 3275 L ++ KL R ++EL ++ + Q ++ L + +LL+ ++ + +R Sbjct: 134 LREDVEKLTVDWSRARDEL--MRKESQWQMEQEFFKGYLKGEHGRLLSLWREVVTFRRHF 191 Query: 3276 YDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSED 3335 + + + + R+L + L++E VR+ T + AQ + +G+G+ P++ Sbjct: 192 LEMKSATD--RDL---MELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGREPAQL 246 Query: 3336 LL-----KELQKQLEEKHSRIVELLNETEKYK---------LDSLQTRQQMEKD------ 3375 LL +EL+K+ E+ +++L ++ + K L +L T+ Q + + Sbjct: 247 LLLLAKTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMI 306 Query: 3376 ----------RQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEG 3425 H + ++ E + Q++ LQ ++D+ + + E+ + + Sbjct: 307 KALRETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGHE 366 Query: 3426 QRLQ---GIMQEFQKQELERE---------EKRESRRILYQNL-----------NEPTTW 3462 L+ I +F Q+ ++ +R++ + L Q L + W Sbjct: 367 NSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQW 426 Query: 3463 SLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMIRQKLQCVASKLQVLP 3522 R + QK+ GE +++ + +++ G + E E++++ + + +L+VL Sbjct: 427 EEEGKALRQRL--QKLTGE-RDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLE 483 Query: 3523 QKA---------------SERLQFETADDEDFIWVQEN--IDEIILQLQKLTGQQGEEPS 3565 Q+A S + Q E +E + V+E + E+++ L+ + E Sbjct: 484 QEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELI 543 Query: 3566 LVSPSTSCGSLTERLLRQN---------------AELTGHISQLTEEKNDLRNMVMKLEE 3610 + + L LLRQ AEL+ + L E DLR +KL Sbjct: 544 TLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSA 603 Query: 3611 -----------------QIRWYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKLT 3653 Q+ Q+ R ++ + N A +E + Sbjct: 604 LNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTH 663 Query: 3654 LQKSLKRAEAEVYKLKAELRN 3674 L+ L++AE +L+A+LR+ Sbjct: 664 LEAQLQKAEEAGAELQADLRD 684 >gi|148746195 trichohyalin [Homo sapiens] Length = 1943 Score = 199 bits (505), Expect = 6e-50 Identities = 399/2017 (19%), Positives = 836/2017 (41%), Gaps = 297/2017 (14%) Query: 215 QQARREKDETMREFLELTEQSQKLQI--QFQQLQASETLRNSTHSSTAADLLQAKQQILT 272 Q+ R+++ E RE E EQS+K + Q + + E L + +A+++ L Sbjct: 135 QRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQ 194 Query: 273 HQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIE 332 + E ++ E+ +++E ++ +EK + QD+ + ++E +++ET++ Sbjct: 195 SCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLR 254 Query: 333 ELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSE 392 + K+ EEE + ELQE+ + Q K + EL +Q+E Q + Sbjct: 255 KEEEKLQEEEPQRQR-------------ELQEE---EEQLRKLERQELRRERQEEEQQQQ 298 Query: 393 EIK--QLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQ 450 ++ Q + +E ++R ++ + E +R EQ+ +R+ +QLR E +E QQ+ + ++ Sbjct: 299 RLRREQQLRRKQEEERREQQEERREQQ--ERREQQEERREQQLRREQEERREQQLRREQE 356 Query: 451 ELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKE 510 E R+ + E+ + R + ++ E Q++ E ++ + +++ Sbjct: 357 EERREQQLRREQEEERREQQLR-----------REQQLRREQQLRREQQLRREQQLRREQ 405 Query: 511 KLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVED 570 +L+ E L E++ ++QL EE ++ Q R+ ++E + E L E+ Sbjct: 406 QLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQE--ERRDWLKREEE 463 Query: 571 LKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLL 630 + + R++ +LK + E + L++ E+E+ +R + E E R Q L Sbjct: 464 TERH----EQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRL 519 Query: 631 FSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNE-MSQKIETMQFEKDNLI 689 EEE +L++ L E ++ E+ + + +++ L+ E Q+++ Q E+ + + Sbjct: 520 KRQEEE-ERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQL 578 Query: 690 TKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQ 749 K+ + + QQ L + E + ++ ++E+E L QEE+ + L++E E + Sbjct: 579 LKREE--------ERRQQRLKREQEERLEQRLK--REEVERLEQEERREQRLKREEPEEE 628 Query: 750 LKTELLEKQMKEKENDLQEKFAQLEAENSILK--DEKKTLEDMLK-------IHTPVSQE 800 + +LL+ + +E+ Q + Q E LK +E++ LE LK +++E Sbjct: 629 RRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEE 688 Query: 801 ERLIFLDSIKSKSKDSVWEKEIEILI---------------------EENEDLKQQCIQL 839 E+ + IKS+ W+ E E EE ++ +Q Sbjct: 689 EQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQW 748 Query: 840 NEE--------IEKQRNTFSF---AEKNFEVNYQE------LQEEYACLLKV-------- 874 EE E+QR F++ AE+ E Q L+E+ L+ Sbjct: 749 QEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQ 808 Query: 875 ----KDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEM 930 +++ ++ + +Q E + +L+ L EE LQR + ++ E++ + E E Sbjct: 809 RFLPEEEEKEQRRRQRREREKELQFLEEEEQLQR------RERAQQLQEEEDGLQEDQER 862 Query: 931 GEVVEKDTTELME-KLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQ 989 E+ + +LE ++ + L EQL++ E L EE + L++E+ + Sbjct: 863 RRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRK---EQQLLQEEEEELQREERE 919 Query: 990 VSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIM 1049 + R E + E +Q + Q+ L + + E K K +E +++ Sbjct: 920 ---KRRRQEQERQYREEEQLQQEEEQL--LREEREKRRRQERERQYRKDKKLQQKEEQLL 974 Query: 1050 VEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDL 1109 E+ ++ ++E+ + + +E + + + +K+ + + E+ L Sbjct: 975 GEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLL 1034 Query: 1110 RLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLEL 1169 R + E +R+ ++ R+Y E E+ +EE + +E +E ++ +LE Sbjct: 1035 REEREKRRL---------QERERQYREEEE----LQQEEEQLLGEE---RETRRRQELER 1078 Query: 1170 QTMKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKEN 1229 Q K +E E + L L++ + + C + E+ E+++ Sbjct: 1079 QYRKEEELQQEEEQL------LREEPEKRRRQERERQCRE---------EEELQQEEEQL 1123 Query: 1230 SGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMK 1289 + + EL+ E ++ Q+ LL + E + R ++ Q + + Sbjct: 1124 LREEREKRRRQELERQYREEEEVQQEEEQLLREEPE--------KRRRQELERQYREEEE 1175 Query: 1290 LEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDL-EKTKLEEQVQ-ELESLI 1347 L+ EE L +EE E + E+ ++ + + +D +++ L+ Q + E E+ + Sbjct: 1176 LQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAV 1235 Query: 1348 SSLQQQLKETEQNYEAEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVK 1407 + K E ++ Q R S+ + L E + +R Sbjct: 1236 RDNKVYCKGRENEQFRQLEDSQLR-DRQSQQDLQHLLGEQQERDREQERRRWQ------- 1287 Query: 1408 KNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGG 1467 + F +E+ + E + +++ +E +++ ++ E R Sbjct: 1288 -------QRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFRE 1340 Query: 1468 KENTASSKQAHAVCQQEQ-HYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEH-- 1524 +E ++ + +QE+ F E +L + G KF EE + L ++ E Sbjct: 1341 EEQLLQEREEQPLRRQERDRKFREEELRHQEQG--------RKFLEEEQRLRRQERERKF 1392 Query: 1525 --GKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLML 1582 ++ L + + +D E+ S+ + R+ +E V + R+ + Sbjct: 1393 LKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQER--DRKFREEEQQVRRQERERKFLE 1450 Query: 1583 NEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSS 1642 E+QL RQE R+++E +Q LL++ +Q+ RQ D++ L+EE ++L RQ R Sbjct: 1451 EEQQL---RQERHRKFREEEQ---LLQEREEQQLHRQERDRKFLEEE-QQLRRQERDRKF 1503 Query: 1643 IDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQTFKE 1702 + E E ER LEE + QL R++ + + + G + + + + + +E Sbjct: 1504 REQELRSQEPERKFLEEEQ---QLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREE 1560 Query: 1703 KELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSK 1762 ++L ++ E+ + LS + R K LE E+ + R ++ K Sbjct: 1561 EQLRQEREE---QQLSRQ--------ERDRKFRLE--------EQKVRRQ-----EQERK 1596 Query: 1763 SQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELS 1822 + R E + ++ + R ++ + + R + + K EE +L Sbjct: 1597 FMEDEQQLRRQEGQQQLRQ-ERDRKFREDEQLLQEREEQQLHRQERD--RKFLEEEPQLR 1653 Query: 1823 QRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRES 1882 ++ E E+ + + R E+LL+ E Q +E Sbjct: 1654 RQ-------------EREQQLRHDRDRKFREEEQLLQEGEE-----------QQLRRQER 1689 Query: 1883 FRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKT 1942 R+ +E + L+ QE R+ L EE + R Q EL ER+ +E+ Sbjct: 1690 DRKFREEEQQLRRQERERKFLQEEQQLRRQ---EL-----------------ERKFREEE 1729 Query: 1943 DIIDRLEQELLCASNRLQEL--------EAEQQQI-QEERELLSRQKEAMKAEAGPVEQQ 1993 + EQE L R +++ E E+QQ+ ++ER+ R++E ++ E E+Q Sbjct: 1730 QLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQER---EEQ 1786 Query: 1994 LLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQ 2053 L+ E K + E Q + E+ L+ Q + + EE+ ++LE+++ + + Sbjct: 1787 QLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQ---LQLEEQEQRLRQERDR 1843 Query: 2054 QNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQ-----QLKVVPRFQPISEHQT 2108 Q +A E+ + + +EQ + +E E+ Q+ +KL + Q K R + + E ++ Sbjct: 1844 QYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREEHIRRQQKEEQRHRQVGEIKS 1903 Query: 2109 REVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEE 2145 +E + L+ T + + + + L IQE+ + Sbjct: 1904 QEGKGHGRLLEPGTHQFASVPVRSSPLYEYIQEQRSQ 1940 Score = 192 bits (489), Expect = 4e-48 Identities = 426/1998 (21%), Positives = 792/1998 (39%), Gaps = 233/1998 (11%) Query: 1567 DEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMER--QREDQE 1624 DE + D L+ + Q ED R+ R Q ++ + RQ Q + E+Q Sbjct: 96 DEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQS 155 Query: 1625 QLQEEIKRLNRQLAQRSSIDNENLVSERE--RVLLEELEALK---------QLSLAGREK 1673 + QE +++ +RQ ERE R E+L++ K + L RE Sbjct: 156 EKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRREL 215 Query: 1674 LCCELRNSSTQTQNGNENQGEV----EEQTFKEKE-LDRKPEDVPPEILSNERYALQKAN 1728 L + + Q E Q V EE+ ++++E + RK E+ E + LQ+ Sbjct: 216 LELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEE 275 Query: 1729 NRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHT 1788 +L K+ + ++ EE + L R + + R + E + E Sbjct: 276 EQLRKLERQELRRERQEEEQQQQR----LRREQQLRRKQEEERREQQEERREQQERREQQ 331 Query: 1789 RVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISS 1848 E R + + + EE E Q+L R E + E E L Sbjct: 332 EERREQ--QLRREQEERREQQLRREQEEERRE--QQLRR------EQEEERREQQLRREQ 381 Query: 1849 RLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESR 1908 +L+ + E QL + + E + R++Q+ + + E E HE+ Sbjct: 382 QLRREQQLRREQQLRREQQLRREQQLRRE---QQLRREQQLRREQQLRREQEEERHEQKH 438 Query: 1909 AREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQ 1968 +E+ L + + + + ER QE+ + +QE L+ E E+++ Sbjct: 439 EQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERRE 498 Query: 1969 IQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEI 2028 QE R EQQL +E E+ +++L+ Q + E+++ L+ + + L Sbjct: 499 QQERR-----------------EQQLRREQEERREQRLKRQEEEERLQQRLRSE-QQLRR 540 Query: 2029 DVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQ 2088 + EE+ + ++ E+EK ++ ++ Q L+++ E+ R L ++ +R +R +QE + Sbjct: 541 EQEERREQLLKREEEKR---LEQERREQRLKREQEERRDQLLKREEERRQQRLKREQE-E 596 Query: 2089 KLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKE-------QLQRDIQE 2141 +LEQ+LK R + Q EQ + + ++ +LL S+E QL+R+ QE Sbjct: 597 RLEQRLK---REEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQE 653 Query: 2142 RNEEIEKLEFRVRELEQALL---VEDRKHFGAVEAKPELSLE--------VQLQAERDAI 2190 R E+ K E LEQ L E+R+ E + E + E Q Q E +A Sbjct: 654 RREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEAD 713 Query: 2191 DRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDM 2250 R+ K + +Q Q R + + E+ ++ +L+ Q++E R Q+ E++ + F Sbjct: 714 ARQSKVYSRPRKQEGQRRR--QEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQW 771 Query: 2251 EKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIE 2310 + + + +S + + +++E ++ Q Q++ + + + E Sbjct: 772 QAEEKSERGRQRLSAR---------PPLREQRERQLRAEERQ----QREQRFLPEEEEKE 818 Query: 2311 EKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMN-AHSL 2369 ++ R+ E +++ L +++ +R R +++++ + +++ Q+ + Q+ L Sbjct: 819 QRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQL 878 Query: 2370 SEEADSLKHQL--DVVIAEKLALEQQV------ETANEEMTFMKNVLKETNFK-MNQLTQ 2420 EE +H L + E+L EQQ+ E EE + +E ++ QL Q Sbjct: 879 EEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQ 938 Query: 2421 ELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEE 2480 E L RE + Q E D + K E + + + E + ++ EE Sbjct: 939 EEEQLLREEREKRRRQ---ERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEE 995 Query: 2481 NGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVE 2540 + E L E + E + Y++ ++Q+ E E L ++ +++ E Sbjct: 996 ------LQQEEEQLLREEREKRRRQEWERQYRKKDELQQ----EEEQLLREEREKRRLQE 1045 Query: 2541 EKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNL-NQLREDELGSDISALTLR 2599 + ++Q E + Q + E E Q L Q R++E Sbjct: 1046 RERQYREEEELQQE----------EEQLLGEERETRRRQELERQYRKEE----------E 1085 Query: 2600 ISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLL-EGNEKKQREKEKKRSP 2658 + + E Q++ EK + + E+ E+E+ E ++LL E EK++R++ +++ Sbjct: 1086 LQQEEEQLLREEP----EKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYR 1141 Query: 2659 QDVEVLKTTTELFHSNEESGFFNELE-ALRAESVATKAELASYKEKAEKLQE--ELLVKE 2715 ++ EV + +L E ELE R E + E +E+ EK ++ E +E Sbjct: 1142 EEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYRE 1201 Query: 2716 TNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLSKSIASQTD 2775 QK + RD + K E E E V+++K C + ++ D Sbjct: 1202 EEELQRQKRKQRYRDEDQRSDLKWQ-WEPEKENAVRDNKVYCKG-----RENEQFRQLED 1255 Query: 2776 GTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTEIISQFTEKIEKMQELHAAEILDME 2835 L+ S Q Q L+ G Q E + F E E+ E + Sbjct: 1256 SQLRDRQSQQDLQHLL---GEQQERDREQERRRWQQRDRHFPE--EEQLEREEQKEAKRR 1310 Query: 2836 SRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREICSS 2895 R E + L RE + +E + Q L+ +E + ++ E+ Sbjct: 1311 DRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQ 1370 Query: 2896 DSGSDWGQGIYLTHSQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLTES 2955 + G +L Q R +E E F K+ + LR E Q+ + Sbjct: 1371 EQGRK-----FLEEEQRL------RRQERER---KFLKE-EQQLRCQERE-QQLRQDRDR 1414 Query: 2956 PYSDGEDH-SIQQVSEPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDW 3014 + + E S Q+ + EE + K L + QL++E + + E Sbjct: 1415 KFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQER--HRKFREEEQLLQE 1472 Query: 3015 RGELLLALQQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECL 3074 R E QQ+ +ER F E L + E R QE ++ + L Sbjct: 1473 REE-----QQLHRQERD---RKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQL 1524 Query: 3075 QKADR-RSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELS 3133 + R R L E Q L Q G++ R+++ + Q E QQ Q + + L Sbjct: 1525 HRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLE 1584 Query: 3134 SMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLK------------AQHKHLKEL 3181 K R E + + ++ +L+ + Q +L E K Q H +E Sbjct: 1585 EQKVRRQEQERKFMEDEQ---QLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQER 1641 Query: 3182 EAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERD---KEELEDL- 3237 + LE + + +K RE + L++ + + R +ERD +EE + L Sbjct: 1642 DRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLR 1701 Query: 3238 ------KFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGR-NLEL 3290 KF E Q+ R +L +++QL E++Q+ ++ Y L EEQ R E Sbjct: 1702 RQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREE 1761 Query: 3291 QVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSR 3350 Q L E+ R L +ERE QL+S + + R E L +E ++Q R Sbjct: 1762 QQLRRQERDRKFREEEQLRQERE-EQQLRSQESDRKFR---EEEQLRQEREEQQLRPQQR 1817 Query: 3351 IVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQ 3410 + E E+ +L+ + R + E+DRQ + E++ T+ + + E ++L ++ Sbjct: 1818 DGKYRWEEEQLQLEEQEQRLRQERDRQ-----YRAEEQFATQEKSRREE-----QELWQE 1867 Query: 3411 LEEKRQQVYKLDLEGQRLQGIMQEFQKQ----ELEREEKRESRRILYQNLNEPTTWSLTS 3466 E+KR+Q + L + ++ +E Q+ E++ +E + R+L EP T S Sbjct: 1868 EEQKRRQERERKLREEHIRRQQKEEQRHRQVGEIKSQEGKGHGRLL-----EPGTHQFAS 1922 Query: 3467 DRTRNWVLQQKIEGETKE 3484 R+ L + I+ + + Sbjct: 1923 VPVRSSPLYEYIQEQRSQ 1940 Score = 185 bits (470), Expect = 7e-46 Identities = 389/1934 (20%), Positives = 786/1934 (40%), Gaps = 242/1934 (12%) Query: 386 KERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQ-ETQRKLEQLRAELDEMYGQQ 444 ++RQ EE Q + Q+R + + +++ +R+EQ + QR+ E+L + E ++ Sbjct: 125 RDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQERE 184 Query: 445 IVQMKQELIR-------QHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINE 497 + ++E ++ + E+++ R E+ R E Q ++ E Sbjct: 185 ERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEE-EE 243 Query: 498 LNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEEL-SFSREQIQRARQTIAEQES 556 + ++T +KE+ K + EE+ QR+L++ E+L R++++R RQ +Q+ Sbjct: 244 KEWRKRETVLRKEEEK-----LQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQ 298 Query: 557 KLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAE 616 +L + E+ + E E R+E + + E + + +L ++E+ R + Sbjct: 299 RLRREQQLRRKQEEERRE---QQEERREQQERREQQEERREQQLRREQEERREQQLRREQ 355 Query: 617 SQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQ 676 +E ++LR E+E + ++ L E ++ E+ + +QQ L+ E Sbjct: 356 EEERREQQLR------REQEEERREQQLRREQQLRREQ-----QLRREQQ---LRREQQL 401 Query: 677 KIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQ-KEIEILRQEE 735 + E Q ++ + ++ QL E Q L + EE Q +E + +E + R++E Sbjct: 402 RRE-QQLRREQQLRREQQLRRE--------QQLRREQEEERHEQKHEQERREQRLKREQE 452 Query: 736 KEKGTLEQEVQELQLKTELLEKQMK-EKENDLQEKFAQLEAENSILKDEKKTLEDMLKIH 794 + + L++E + + + E ++Q+K ++E + +E++ +LE E +++++ E L+ Sbjct: 453 ERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEER--REQQERREQQLRRE 510 Query: 795 TPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAE 854 +E+RL K E+ ++ + + L+++ + E++ K+ + Sbjct: 511 QEERREQRL----------KRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQ 560 Query: 855 KNFEVNYQELQEEYA-CLLKVKDDLEDSKNKQELEYKSKLKALNEEL-HLQRINPTTVKM 912 + E + QEE LLK +++ + K+E E + + + EE+ L++ ++ Sbjct: 561 ERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRL 620 Query: 913 KSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGE 972 K +E++ + L+ E E+ +L + + + ++L+ + L ++LK++H E Sbjct: 621 KREEPEEERR--QQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEE 678 Query: 973 ISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAE 1032 E + ++E+EQ R + + Q+ S D + Sbjct: 679 ---ERREQELAEEEQEQARERIK-----------SRIPKWQWQLESEADARQSKVYSRPR 724 Query: 1033 GSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSEN 1092 + + EE + E ++ ++ +QE+ + T + Sbjct: 725 KQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEE---EQRRDFTWQWQAEEKSERGR 781 Query: 1093 DKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIF 1152 +L + + + LR + QR L +Q R E++K L L+EE Sbjct: 782 QRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQ-RRRQRREREKELQFLEEEEQL 840 Query: 1153 AQEEKIKELQKIH---QLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSV 1209 + E+ ++LQ+ Q + + ++QE + K + + EE TL Sbjct: 841 QRRERAQQLQEEEDGLQEDQERRRSQEQRRD--------QKWRWQLEEERKRRRHTL--- 889 Query: 1210 LGEYYTPALKCEVNAEDKENSGDYISENEDPELQ--------------DYRYEVQDFQEN 1255 Y PAL+ ++ E + + + E+ ELQ YR E Q Q+ Sbjct: 890 ---YAKPALQEQLRKEQQ------LLQEEEEELQREEREKRRRQEQERQYREEEQ-LQQE 939 Query: 1256 MHTLLNKVTE---------EYNKLLVLQTRLSKIWGQQTDGMKLE------FGEENLPKE 1300 LL + E +Y K LQ + ++ G++ + + + EE L +E Sbjct: 940 EEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQE 999 Query: 1301 ETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEE----QVQELESLISSLQQQLKE 1356 E + L + ++ + ++ K Q+ E+ EE ++QE E +++L++ Sbjct: 1000 EEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYRE-EEELQQ 1058 Query: 1357 TEQNYEAEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEF 1416 E+ E ++R + + L + + + ++ + + ++ Sbjct: 1059 EEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQ 1118 Query: 1417 SGEFGVKEETNIVKL--LEKQYQEQLE-EEVAKVIVSMSIAFAQQTELSR-------ISG 1466 E ++EE + LE+QY+E+ E ++ + ++ ++ EL R + Sbjct: 1119 EEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQ 1178 Query: 1467 GKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVK--FKEEFKPLSKELGEH 1524 +E +Q ++E+ Y E +L Q Q Q + D + K +++P KE Sbjct: 1179 EEEQLLREEQEKRRQERERQYREEEEL-QRQKRKQRYRDEDQRSDLKWQWEP-EKENAVR 1236 Query: 1525 GKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNE 1584 ++ + + +D L + +Q E + E Sbjct: 1237 DNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEE 1296 Query: 1585 EQLE-DMRQELVRQYQEHQQATELLRQAHMRQMERQ------REDQEQLQE-EIKRLNRQ 1636 EQLE + ++E R+ ++ Q+ +LLR+ + RQ RE+++ LQE E + L RQ Sbjct: 1297 EQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQ 1356 Query: 1637 LAQRSSIDNENLVSERERVLLEELEALKQLS-----LAGREKLCCELRNSSTQTQNGNEN 1691 R + E E+ R LEE + L++ L ++L C+ R Q + + Sbjct: 1357 ERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQ--QLRQDRDR 1414 Query: 1692 QGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGR 1751 + EEQ +E DRK + ++ ER + LE + R Sbjct: 1415 KFREEEQQLSRQERDRKFREEEQQVRRQERE----------RKFLEEEQQLRQERHRKFR 1464 Query: 1752 HVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMW 1811 +L + Q + R E + + + EE E + ++ + Sbjct: 1465 EEEQLLQEREEQQ-----LHRQERD---RKFLEEEQQLRRQERDRKFREQELRSQEPE-- 1514 Query: 1812 SKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHA 1871 K EE +L ++ + F E +E R Q K E QL Sbjct: 1515 RKFLEEEQQLHRQQRQRKFLQEEQQLRRQE---RGQQRRQDRDRKFRE-----EEQLRQE 1566 Query: 1872 KVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEK 1931 + Q +E R+ + + ++ QE+ R+ + +E + R Q + + E DE+ Sbjct: 1567 REEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQ 1626 Query: 1932 TLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVE 1991 L ER+ EQ+L + LE E Q ++ERE R K E Sbjct: 1627 LLQERE-----------EQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFRE---E 1672 Query: 1992 QQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDL 2051 +QLLQE E+ + E + + L++Q + + EEQ R ELE++ E Sbjct: 1673 EQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLR 1732 Query: 2052 RQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREV 2111 ++ Q ++ E+ RK L+E+ + E E EQQL+ R + + RE Sbjct: 1733 QETEQEQLRRQERYRKILEEEQLRPERE-----------EQQLRRQER-----DRKFREE 1776 Query: 2112 EQLANHLKE---KTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVEDRKHF 2168 EQL +E ++ + +EQL+++ +E+ ++ + + R E+ L +E++ Sbjct: 1777 EQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQ--- 1833 Query: 2169 GAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQ 2228 E +L+ ERD R E++ E+ REE E EE Q+ + E + Sbjct: 1834 -----------EQRLRQERDRQYRAEEQFATQEKSR---REEQELWQEEEQKRRQERERK 1879 Query: 2229 KKESTTRLQELEQE 2242 +E R Q+ E++ Sbjct: 1880 LREEHIRRQQKEEQ 1893 Score = 172 bits (436), Expect = 6e-42 Identities = 371/1845 (20%), Positives = 762/1845 (41%), Gaps = 222/1845 (12%) Query: 167 KQHEIEEL-------NRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARR 219 K HE EE REL E+R E QQ +E + + Q + + R+ Sbjct: 197 KGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEE-KEWRKRETVLRK 255 Query: 220 EKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQ---- 275 E+++ E + + Q+ + Q ++L+ E R L+ +QQ+ Q+ Sbjct: 256 EEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERR 315 Query: 276 -QLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEEL 334 Q EE+ E ++++E Q+ QE+ + ++ ++++ E ++ +E+E EE Sbjct: 316 EQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQE---EER 372 Query: 335 NTKIIEEEKKTLELKDKLTTADKLLGELQ---EQIVQKNQEIKNMKLELTNSKQKERQSS 391 + + E++ L + +L +L E Q EQ +++ Q+++ + +L +Q R+ Sbjct: 373 REQQLRREQQ-LRREQQLRREQQLRREQQLRREQQLRREQQLRREQ-QLRREQQLRREQE 430 Query: 392 EEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQ----ETQRKLEQLRAELDEMYGQQIVQ 447 EE + E ++R ++ + D ++R E+ E +R+ +QL+ + +E ++ ++ Sbjct: 431 EERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLK 490 Query: 448 MKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNS 507 +++E R+ + E+ R + E R + E++ +L +E ++ + Sbjct: 491 LEEEERREQQERREQQLRREQEE-----RREQRLKRQEEEERLQQRLRSEQQLRREQEER 545 Query: 508 QKEKLKEELGLILEE---KCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKS 564 +++ LK E LE+ + L+R+ E+ ++L RE+ +R ++ EQE +L + K Sbjct: 546 REQLLKREEEKRLEQERREQRLKREQEERRDQL-LKREEERRQQRLKREQEERLEQRLK- 603 Query: 565 LSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELER 624 R+E+E + E ++K E E+E+ L + E +E ++ Sbjct: 604 -----------------REEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQ 646 Query: 625 LRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFE 684 LR + E+ L + +E+ +E R+ E ++ +++ + + E Q E + Sbjct: 647 LRREQQERREQRLKREEEEERLEQRLKREHEEE------RREQELAEEEQEQARERI--- 697 Query: 685 KDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQE-----EKEKG 739 K + Q QL E D +QS V S+ + Q ++E + R+E ++E+ Sbjct: 698 KSRIPKWQWQLESE----ADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEER 753 Query: 740 TLEQEVQELQLKTELLEKQMKEKENDLQEKFA-----------QLEAENSILKDEKKTLE 788 Q+ +E Q + + Q +EK +++ + QL AE ++++ E Sbjct: 754 AHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPE 813 Query: 789 DMLKIHTPVSQEER---LIFL---DSIKSKSKDSVWEKEIEILIEENEDLKQQ------- 835 + K + ER L FL + ++ + + ++E + L E+ E + Q Sbjct: 814 EEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQK 873 Query: 836 -CIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDS------KNKQELE 888 QL EE +++R+T +A+ + ++L++E L + +++L+ + +QE + Sbjct: 874 WRWQLEEERKRRRHTL-YAKPALQ---EQLRKEQQLLQEEEEELQREEREKRRRQEQERQ 929 Query: 889 YKSKLKALNEE---LHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKL 945 Y+ + + EE L +R + + + K E +GE EK + EK Sbjct: 930 YREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREK- 988 Query: 946 EVTKREKLELSQRLSDL--SEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINH 1003 RE+ EL Q L E+ K++ E + L+QE+EQ+ RE + Sbjct: 989 --KYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQER 1046 Query: 1004 NRAENVQSCDTQVSSLLDGVVTMTSR--GAEGSVSKVNKSFGEESKIMVEDKVSFENMTV 1061 R + Q L G T R E K + EE +++ E+ Sbjct: 1047 ERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQER 1106 Query: 1062 GEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLS 1121 + ++E+ + + +E + + + ++E V + E+ LR + E +R Sbjct: 1107 ERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRR---- 1162 Query: 1122 LVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEK---IKELQKIHQLELQTMK-TQET 1177 + R+Y E E+ L +E+L+ ++EK +E Q + ELQ K Q Sbjct: 1163 -----RQELERQYREEEE---LQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRY 1214 Query: 1178 GDEGKPLHL---LIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKEN-SGDY 1233 DE + L + + AV + Y + L+ + +D ++ G+ Sbjct: 1215 RDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQ 1274 Query: 1234 ISENEDPELQDYRYEVQDFQENMHTLLNKVTE--------EYNKLLVLQTRLSKIWGQQT 1285 + + E + ++ + F E + E + K L+ + R K Q+T Sbjct: 1275 QERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQET 1334 Query: 1286 DGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELES 1345 D K E+ L + E + L + + ++ H+ + + E+ +L Q +E + Sbjct: 1335 D-RKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLE-EEQRLRRQERERKF 1392 Query: 1346 LISSLQQQLKETEQNYEAE-IHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGS 1404 L Q + +E EQ + ++ Q +S + + + +R Sbjct: 1393 LKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEE 1452 Query: 1405 CVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRI 1464 + + +F E + +E +L ++ + EE ++ ++ EL Sbjct: 1453 QQLRQ-ERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQ 1511 Query: 1465 SGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEH 1524 ++ +Q H +Q + E +L + + G Q + D KF+EE ++L + Sbjct: 1512 EPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREE-----EQLRQE 1566 Query: 1525 GKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNE 1584 +E LS + +D+ F + +E V + R+ M +E Sbjct: 1567 REEQQLSRQE--------------------RDRKFRL-----EEQKVRRQEQERKFMEDE 1601 Query: 1585 EQL------EDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLA 1638 +QL + +RQE R+++E +Q LL++ +Q+ RQ D++ L+EE + ++ Sbjct: 1602 QQLRRQEGQQQLRQERDRKFREDEQ---LLQEREEQQLHRQERDRKFLEEEPQLRRQERE 1658 Query: 1639 QRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQ-TQNGNENQGEVEE 1697 Q+ D + E E++L E E +QL R++ + R Q + E + EE Sbjct: 1659 QQLRHDRDRKFREEEQLLQEGEE--QQLRRQERDR---KFREEEQQLRRQERERKFLQEE 1713 Query: 1698 QTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGIL 1757 Q + +EL+RK + E+ L++ R KIL E E+ + R Sbjct: 1714 QQLRRQELERKFREEEQLRQETEQEQLRR-QERYRKILEEEQLRPEREEQQLRRQ----- 1767 Query: 1758 DRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEE 1817 +R K + L R E E ++ + S R + + + E+ Sbjct: 1768 ERDRKFREEEQL--RQERE---------------EQQLRSQESDRKFREEEQLRQEREEQ 1810 Query: 1818 GTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTE 1877 QR + + ++ E +E RL+ ++ A + ++Q E ++ + E Sbjct: 1811 QLRPQQRDGKYRWEEEQLQLEEQE------QRLRQERDRQYRAEEQFATQ-EKSRREEQE 1863 Query: 1878 LMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEG 1922 L +E +++++ E +E +R + EE R R+ ++ + +G Sbjct: 1864 LWQEEEQKRRQERERKLREEHIRRQQKEEQRHRQVGEIKSQEGKG 1908 Score = 163 bits (413), Expect = 3e-39 Identities = 387/2025 (19%), Positives = 800/2025 (39%), Gaps = 292/2025 (14%) Query: 700 SKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQ-ELQLKTELLEKQ 758 S L+D +Q + E Q+ E + +++E+E+ E E Q E Q + E ++Q Sbjct: 108 SLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQ 167 Query: 759 MKEKE--------NDLQEKFAQLEA-------ENSILKDE----KKTLEDMLKIHTPVSQ 799 +++E + +E+ A+ E E DE ++ L ++ + Q Sbjct: 168 RRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQ 227 Query: 800 EERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEV 859 ++R D + + ++ W K +L +E E L++ EE ++QR E+ ++ Sbjct: 228 QQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQE------EEPQRQRELQEEEEQLRKL 281 Query: 860 NYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDE 919 QEL+ E E+ + +Q L + +L+ EE ++ E Sbjct: 282 ERQELRRERQ---------EEEQQQQRLRREQQLRRKQEEERREQ-------------QE 319 Query: 920 DKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEE 979 ++ E E E E+ +L + E + ++L Q +QL+++ E ++ Sbjct: 320 ERREQQERREQQE--ERREQQLRREQEERREQQLRREQEEERREQQLRREQEE-ERREQQ 376 Query: 980 VKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVN 1039 ++ +Q + + LR RE ++ R E + Q+ + Sbjct: 377 LRREQQLRREQQLR-REQQL-----RREQQLRREQQL--------------------RRE 410 Query: 1040 KSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKEL 1099 + E ++ E ++ E E K EQ +E L+ Q D L++E Sbjct: 411 QQLRREQQLRREQQLRREQEEERHEQKHEQ--------ERREQRLKREQEERRDWLKREE 462 Query: 1100 NVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIK 1159 + EQ + Q++ + E E+ + L+EE Q+E+ + Sbjct: 463 ETERHEQERRKQQLKRDQ------------------EEERRERWLKLEEEERREQQERRE 504 Query: 1160 ELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALK 1219 + + Q E + + + +E + LQ+ + E Sbjct: 505 QQLRREQEERREQRLKRQEEEER--------LQQRLRSEQ-------------------- 536 Query: 1220 CEVNAEDKENSGDYISENEDPELQDYRYEVQ---DFQENMHTLLNKVTEEYNKLLV---- 1272 ++ E +E + E+ L+ R E + + +E LL + E + L Sbjct: 537 -QLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQE 595 Query: 1273 --LQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQD 1330 L+ RL + ++ + ++ E E K E Q+ E+ + + +L Q Sbjct: 596 ERLEQRLKR---EEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQ 652 Query: 1331 LEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSESTVPPSLPVDSVV 1390 + + ++ +E E L L+++ +E + E L + Q + + +P Sbjct: 653 ERREQRLKREEEEERLEQRLKREHEEERREQE-----LAEEEQEQARERIKSRIPKWQWQ 707 Query: 1391 I-TESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIV 1449 + +E+DA+++ K+ + E + E+ + E++ Q +EE + Sbjct: 708 LESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDF 767 Query: 1450 SMSIAFAQQTE-----LSRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFE 1504 + +++E LS +E +A Q+EQ + E + + + + Sbjct: 768 TWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRRER 827 Query: 1505 TVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQS 1564 +++F EE + L + E +++ + + E ++ + + K + + + Sbjct: 828 EKELQFLEEEEQLQRR--ERAQQL---QEEEDGLQEDQERRRSQEQRRDQKWRWQLEEER 882 Query: 1565 IHDEISVSSMDASRQLMLNEEQL-EDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQ 1623 ++ + A ++ + E+QL ++ +EL R+ +E ++ E RQ + + + Q+E++ Sbjct: 883 KRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQ-YREEEQLQQEEE 941 Query: 1624 EQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSST 1683 + L+EE ++ RQ +R ++ L + E++L EE E ++ + + EL+ Sbjct: 942 QLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEE 1001 Query: 1684 QT---QNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVK 1740 Q + + E E Q K+ EL ++ E + E R ++ R + L + + Sbjct: 1002 QLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEE 1061 Query: 1741 TTAAVE-ETIGRHVLGILDRSSKS-QSSASLIWRSEAEAS-----VKSCVHEEHTRVTDE 1793 E ET R L R + Q + R E E + C EE + +E Sbjct: 1062 QLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEE 1121 Query: 1794 SIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAA 1853 + R ++ + EE + ++L+R +PE R + Sbjct: 1122 QLLREEREKRRRQELERQYREEEEVQQEEEQLLRE-------EPEK---------RRRQE 1165 Query: 1854 VEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQL 1913 +E+ E + E + E R+ ++ E L+ Q+ + E+ R+ + Sbjct: 1166 LERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKW 1225 Query: 1914 AVELSKAEGVIDGYADEKTLFERQIQEKTD--IIDRLEQELLCASNRLQELEAEQQQIQE 1971 E K V D K Q ++ D + DR Q+ LQ L EQQ+ Sbjct: 1226 QWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQ------DLQHLLGEQQERDR 1279 Query: 1972 ERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVE 2031 E+E R++ + P E+QL +E +K K RD ++ K L + Sbjct: 1280 EQE---RRRWQQRDRHFPEEEQLEREEQKEAKR-----------RDRKSQEEKQLLREER 1325 Query: 2032 EQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLE 2091 E+ R E +++ E L+++ + ++ E+ RKF +E+ +E R ++E Q+L Sbjct: 1326 EEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEE-QRLR 1384 Query: 2092 QQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEF 2151 +Q + + + + +E EQ +++ + E LS+++ R +E +++ + E Sbjct: 1385 RQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQER 1444 Query: 2152 RVRELEQALLVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREEL 2211 + LE+ + +H E + L + E + R+E++ LEE+ + R+E Sbjct: 1445 ERKFLEEEQQLRQERHRKFREEEQLLQ-----EREEQQLHRQERDRKFLEEEQQLRRQER 1499 Query: 2212 ENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVL 2271 + K E + + E + E +L +++ K +++ + L +E QD+ Sbjct: 1500 DRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQ---LRRQERGQQRRQDRDRK 1556 Query: 2272 FGKFAQIIQEKE------VEID---QLNEQVTKLQQQLKITTDNKVIEEKNELIR----- 2317 F + Q+ QE+E E D +L EQ + Q+Q + K +E++ +L R Sbjct: 1557 FREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQ-----ERKFMEDEQQLRRQEGQQ 1611 Query: 2318 DLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLK 2377 L + + + E + + REE+ E K +E + ++ E L+ Sbjct: 1612 QLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQ---------EREQQLR 1662 Query: 2378 HQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQS 2437 H D K E+Q+ EE + +E + K + Q+L +RER+ +++ Q Sbjct: 1663 HDRD----RKFREEEQLLQEGEEQQLRR---QERDRKFREEEQQLRRQERERKFLQEEQQ 1715 Query: 2438 IPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLE 2497 + L + E E + E + L Q ++ E + E +L + E Sbjct: 1716 LRR-------QELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQE 1768 Query: 2498 STVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQ 2557 ++ E Q++ +E+ Q ++ +K +++ +E+ + QL Q Sbjct: 1769 RDRKFREEE------QLRQEREEQQLRSQESDRKFREEEQLRQER------EEQQLRPQQ 1816 Query: 2558 EYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILE 2617 K+ + + + E + Q L Q R+ + ++ T S E Q L E Sbjct: 1817 RDGKYRWEEEQLQLEEQE---QRLRQERDRQYRAEEQFATQEKSRREEQ------ELWQE 1867 Query: 2618 KEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVE 2662 +EQ K E+E+KL E E ++Q+E+++ R +++ Sbjct: 1868 EEQ-----KRRQERERKLRE-----EHIRRQQKEEQRHRQVGEIK 1902 Score = 140 bits (354), Expect = 2e-32 Identities = 253/1275 (19%), Positives = 526/1275 (41%), Gaps = 180/1275 (14%) Query: 15 AKLAQFRQRKAQSDGQSPSKKQKKKRKTSSSK----HDVSAHHDLNIDQS--------QC 62 A+ ++ R + +GQ ++Q++KR+ S+ + AH ++ Q Sbjct: 714 ARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQA 773 Query: 63 NEMYINSSQRVESTVIPESTIMRTLHSGEITSHEQGFSVELESEISTTADDCSSEVNGCS 122 E QR+ + R L + E EQ F E E + E Sbjct: 774 EEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKE-LQ 832 Query: 123 FV-----MRTGKPTNLLREEEFGVDDSYSEQGAQDS------------------------ 153 F+ ++ + L+EEE G+ + + +Q+ Sbjct: 833 FLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAK 892 Query: 154 PTHLEMMESELAGKQHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTAN 213 P E + E Q E EEL RE E R E +Q +E E ++ + ++ + Sbjct: 893 PALQEQLRKEQQLLQEEEEELQREEREKRRRQEQE--RQYREEEQLQQEEEQLLRE---- 946 Query: 214 LQQARREKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAA-----DLLQAKQ 268 ++ +R + E R++ + +KLQ + +QL E + +L Q ++ Sbjct: 947 -EREKRRRQERERQY----RKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEE 1001 Query: 269 QILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKE 328 Q+L +++ + Y+KK E + L+E+ + +++ ++ +E QE+E Sbjct: 1002 QLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEE 1061 Query: 329 TII-EELNTKIIEE-----------------------EKKTLELKDKLTTADKLLGELQE 364 ++ EE T+ +E EK+ + +++ ++ L + +E Sbjct: 1062 QLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEE 1121 Query: 365 QIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQF--ETDIVQRM 422 Q++++ +E K + EL ++E + +E +QL+ E ++R + Q+ E ++ Q Sbjct: 1122 QLLREERE-KRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEE 1180 Query: 423 EQETQRKLEQLRAELDEMY--GQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRS--- 477 EQ + + E+ R E + Y +++ + K++ + Q ++K + + E ENA+R Sbjct: 1181 EQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKV 1240 Query: 478 YSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEEL 537 Y NE +L + +L+D SQ++ L+ LG E +R+ + Sbjct: 1241 YCKGRENEQFRQLE-------DSQLRDRQSQQD-LQHLLGEQQERDREQERRRWQQRDRH 1292 Query: 538 SFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYK 597 EQ++R Q A++ + ++ K L R+E E K + T+ K Sbjct: 1293 FPEEEQLEREEQKEAKRRDRKSQEEKQL---------------LREEREEKRRRQETDRK 1337 Query: 598 IKLE--MLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEK- 654 + E +L++ + L R ++ E LR H+E+ K E+ + R E+ Sbjct: 1338 FREEEQLLQEREEQPLRRQERDRKFREEELR------HQEQGRKFLEEEQRLRRQERERK 1391 Query: 655 -LKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSK 713 LK+ + +++ L+ + +K E++ +++Q + K ++ +Q + + Sbjct: 1392 FLKEEQQLRCQEREQQLRQDRDRKFR----EEEQQLSRQER----DRKFREEEQQVRRQE 1443 Query: 714 SEEMTLQINELQKEIEILRQEE----KEKGTLEQEVQELQLKTELLEKQMKEKENDLQ-- 767 E L+ E + LRQE +E+ L QE +E QL + +++ E+E L+ Sbjct: 1444 RERKFLE------EEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQ 1497 Query: 768 ---EKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEI 824 KF + E + + E+K LE+ ++H Q + L ++ + + ++ + Sbjct: 1498 ERDRKFREQELRSQ--EPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDR 1555 Query: 825 LIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNK 884 E E L+Q+ + +++ +Q F + +V QE + ++ ++ + L + + Sbjct: 1556 KFREEEQLRQE--REEQQLSRQERDRKFRLEEQKVRRQEQERKF---MEDEQQLRRQEGQ 1610 Query: 885 QELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVE--------- 935 Q+L + K +E LQ + + + D+ F+ E ++ Sbjct: 1611 QQLRQERDRKFREDEQLLQEREEQQLHRQ----ERDRKFLEEEPQLRRQEREQQLRHDRD 1666 Query: 936 ---KDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSL 992 ++ +L+++ E + + E ++ + +QL+++ E FL EE + +QE E+ Sbjct: 1667 RKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELER--- 1723 Query: 993 RCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVED 1052 + RE E + E ++ + L + + + + ++ F EE ++ E Sbjct: 1724 KFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQER 1783 Query: 1053 KVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQ 1112 + E +ES ++ + L +E LR Q + K + E L+ E+ + RL+ Sbjct: 1784 E---EQQLRSQESDRKFREEEQLRQEREEQQLRPQQ--RDGKYRWEEEQLQLEEQEQRLR 1838 Query: 1113 MEAQR-ICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQT 1171 E R ++T RE E +++ +E +EE I+ QK Q Q Sbjct: 1839 QERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREEHIRRQQKEEQRHRQV 1898 Query: 1172 --MKTQETGDEGKPL 1184 +K+QE G+ L Sbjct: 1899 GEIKSQEGKGHGRLL 1913 Score = 135 bits (341), Expect = 6e-31 Identities = 242/1224 (19%), Positives = 521/1224 (42%), Gaps = 161/1224 (13%) Query: 2 EDEERQKKL---EAGKAKLAQFRQRKAQSDGQSPSKKQKKKRKTSSSKHDVSAHHDLNID 58 E+E RQ+ L E + + Q R+ + + Q ++++++R K + H + + Sbjct: 626 EEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKRE---HEEERRE 682 Query: 59 QSQCNEMYINSSQRVESTVIPESTIMRTLHSGEITSHEQGFSVELESEISTTADDCSSEV 118 Q E + +R++S IP+ + +LESE AD S+V Sbjct: 683 QELAEEEQEQARERIKSR-IPK------------------WQWQLESE----ADARQSKV 719 Query: 119 NGCSFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHEIEELNREL 178 R K R +E E+ + + L+ E E A +Q + EE R+ Sbjct: 720 -----YSRPRKQEGQRRRQE-------QEEKRRRRESELQWQEEERAHRQQQEEEQRRDF 767 Query: 179 --EEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREK---DETMREFLELTE 233 + G Q+L +QR+ QL A +Q R ++ +E +E Sbjct: 768 TWQWQAEEKSERGRQRLSARPPLREQRE---RQLRAEERQQREQRFLPEEEEKEQRRRQR 824 Query: 234 QSQKLQIQF----QQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQD--HLLEDY 287 + ++ ++QF +QLQ E + D LQ Q+ Q+Q +Q LE+ Sbjct: 825 REREKELQFLEEEEQLQRRERAQQLQEEE---DGLQEDQERRRSQEQRRDQKWRWQLEEE 881 Query: 288 QKKKEDFTMQISFLQEKIK------------VYEMEQDKKVENSNKEEIQEKETIIEELN 335 +K++ LQE+++ + E++K+ + + +E+E + +E Sbjct: 882 RKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEE 941 Query: 336 TKIIEE-EKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEI 394 + EE EK+ + +++ DK L + +EQ++ + E K + E ++E + +E Sbjct: 942 QLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPE-KRRRQEREKKYREEEELQQEE 1000 Query: 395 KQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIR 454 +QL+ E ++R + Q+ + E+E + E+ + L E Q ++E ++ Sbjct: 1001 EQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQ---YREEEELQ 1057 Query: 455 QHMAQM--EEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKL 512 Q Q+ EE +TR + E+E R + E+Q+ L++ ++ + Sbjct: 1058 QEEEQLLGEERETRRRQELERQYRKEEELQQEEEQL-------------LREEPEKRRRQ 1104 Query: 513 KEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLK 572 + E EE+ LQ++ E L+ E R + + RQ E+E + E + L+ Sbjct: 1105 ERERQCREEEE--LQQEEEQLLREEREKRRRQELERQYREEEEVQQEEE-------QLLR 1155 Query: 573 AEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFS 632 E E + + E E+ + +L E+EK +E EL+R + + + Sbjct: 1156 EEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYR 1215 Query: 633 HEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQ 692 E++ S LK E E K+N K G +NE +++E Q +D + Sbjct: 1216 DEDQRSDLKWQWEPE--------KENAVRDNKVYCKGRENEQFRQLEDSQL-RDRQSQQD 1266 Query: 693 NQLILEISKLKDLQQ----------------SLVNSKSEEMTLQINELQKEIEILRQEEK 736 Q +L + +D +Q L + +E + + Q+E ++LR+E + Sbjct: 1267 LQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREERE 1326 Query: 737 EKGTLEQEVQELQLKTELLEKQMKE--KENDLQEKFAQLEAENSILKDEKKTLEDMLKIH 794 EK ++ ++ + + +LL+++ ++ + + KF + E + + +K LE+ ++ Sbjct: 1327 EKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQ--EQGRKFLEEEQRLR 1384 Query: 795 TPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAE 854 QE FL K + + E+E ++ + + +++ +++ +Q F E Sbjct: 1385 ---RQERERKFL---KEEQQLRCQEREQQLRQDRDRKFREE----EQQLSRQERDRKFRE 1434 Query: 855 KNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNE-ELHLQRINPTTVKMK 913 + +V QE + ++ L+ + L ++++ E + L+ E +LH Q + ++ + Sbjct: 1435 EEQQVRRQERERKF---LEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEE 1491 Query: 914 SSV--FDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQ----RLSDLSEQLK 967 + + D+ F + L E E+ E ++L +R++ L + R + +Q + Sbjct: 1492 QQLRRQERDRKFREQELRSQE-PERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRR 1550 Query: 968 QKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMT 1027 Q + F EE ++E++Q+S + R+ + + + V+ + + + D Sbjct: 1551 QDR-DRKFREEEQLRQEREEQQLSRQERDRKFRLEE---QKVRRQEQERKFMEDEQQLRR 1606 Query: 1028 SRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRAT 1087 G + + ++ F E+ +++ E + E +E +++ L+ P + ++ + Sbjct: 1607 QEGQQQLRQERDRKFREDEQLLQERE---EQQLHRQE--RDRKFLEEEPQLRRQEREQQL 1661 Query: 1088 QPSENDKLQKELNVL-KSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSL 1146 + + K ++E +L + E+ LR Q ++ ++ R++++ E+ L Sbjct: 1662 RHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQEL 1721 Query: 1147 KEELIFAQEEKIKELQKIHQLELQ 1170 + + F +EE++++ + QL Q Sbjct: 1722 ERK--FREEEQLRQETEQEQLRRQ 1743 Score = 108 bits (271), Expect = 8e-23 Identities = 251/1261 (19%), Positives = 503/1261 (39%), Gaps = 161/1261 (12%) Query: 2278 IIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDL---ETQIECLMSDQECVK 2334 ++Q++ E DQ + +QL+ + +++ E R+L E Q E ++ + Sbjct: 109 LLQDRRQEEDQ--RRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDR 166 Query: 2335 RNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSE--EADSLKHQLDVVIAEKLALE- 2391 + R+EE+ + + ++ ++ A Q S H E + + L+ + + + K E Sbjct: 167 QRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEK 226 Query: 2392 QQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEK-IQSIPENSVNVAIDHL 2450 QQ ++ F + KE + L +E L+ E ++ +Q E + L Sbjct: 227 QQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQEL 286 Query: 2451 SKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQC 2510 +++ E E + + Q + EE + + + E ++ +L + Sbjct: 287 RRERQEEE----QQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRRE 342 Query: 2511 YKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQ--DNQT 2568 ++ ++ Q + + E E ++++ Q+ EE+ L + QL Q+ + Q Q Sbjct: 343 QEERREQQLRREQEEERREQQLRREQE--EERREQQLRREQQLRREQQLRREQQLRREQQ 400 Query: 2569 ISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNV 2628 + E + Q L RE +L + LR + E + + H E+E+ E K Sbjct: 401 LRREQQLRREQQLR--REQQLRREQQ---LRREQEEERHEQKH-----EQERREQRLKRE 450 Query: 2629 LEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRA 2688 E+ + L+ ++ E +E+++R+++ KR Q+ E + +L + LR Sbjct: 451 QEERRDWLKREEETERHEQERRKQQLKRD-QEEERRERWLKLEEEERREQQERREQQLRR 509 Query: 2689 ESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDET 2748 E + + +E+ E+LQ+ L ++ Q+R E +E+L L++E+E Sbjct: 510 EQEERREQRLKRQEEEERLQQRLRSEQ-----------QLRREQEERREQL--LKREEEK 556 Query: 2749 EVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEE 2808 +++ ++ +L + + D LK + ++ + + L+ EE Sbjct: 557 RLEQERREQ-------RLKREQEERRDQLLKREEERRQQRLKREQ---EERLEQRLKREE 606 Query: 2809 VTEIISQFTE----KIEKMQELHAAEILDMESRHISETETLKREHYVA-VQLLKEECGTL 2863 V + + K E+ +E ++L E + + L+RE Q LK E Sbjct: 607 VERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEE 666 Query: 2864 KAVIQCLRS-KEGSSIPELAHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIASEGRGE 2922 + + R +E ELA + Q RE S W + E + Sbjct: 667 RLEQRLKREHEEERREQELAEEEQEQARERIKSRIPK-WQWQL------------ESEAD 713 Query: 2923 ESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINT 2982 +S S P+K +G R E + +E + + E QQ E E+R+ Sbjct: 714 ARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEE---EQRR----- 765 Query: 2983 ISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELT 3042 D + Q + ++E RG L+ + E+R L A + Sbjct: 766 -----DFTWQWQAEEKSE--------------RGRQRLSARPPLREQRERQLRAEERQQR 806 Query: 3043 ALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHA----QMNGRKI 3098 EQR + E + ++ RR E+Q L Q R Sbjct: 807 --------------EQRFLPEEEEKEQ-----RRRQRREREKELQFLEEEEQLQRRERAQ 847 Query: 3099 TLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRAT-----ELQEQLSSEKMVV 3153 L+ E++ + QE +Q++ Q Q+E + R T LQEQL E+ ++ Sbjct: 848 QLQEEEDGLQEDQERRRSQ-EQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLL 906 Query: 3154 AELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQ 3213 E + EL + + E + + ++ +R E + + +E LL + +++ RE Q Sbjct: 907 QEEEEELQREERE-------KRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQ 959 Query: 3214 WALEK-----EKAKLGRSEE-----------RDKEELEDLKFSL---ESQKQRNLQLNLL 3254 + +K E+ LG E R++EEL+ + L E +K+R + Sbjct: 960 YRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQ 1019 Query: 3255 LEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDREREL 3314 ++ +L E +Q + +R Q E Q R E + L + E+ + E T R +EL Sbjct: 1020 YRKKDELQQEEEQLLREEREKRRLQERERQYR--EEEELQQEEEQLLGEERET-RRRQEL 1076 Query: 3315 HAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEK 3374 Q + + Q L E+ K +++ E + EL E E+ + + R++ E Sbjct: 1077 ERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQEL 1136 Query: 3375 DRQVHRK---TLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGI 3431 +RQ + + EQ E +K+ + + + +L+++ +Q+ + + E +R + Sbjct: 1137 ERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERE 1196 Query: 3432 MQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLI 3491 Q +++EL+R+++++ R Q + W N V K+ + +E+ + + Sbjct: 1197 RQYREEEELQRQKRKQRYRDEDQRSDLKWQW---EPEKENAVRDNKVYCKGRENEQFRQL 1253 Query: 3492 E 3492 E Sbjct: 1254 E 1254 Score = 99.8 bits (247), Expect = 5e-20 Identities = 230/1155 (19%), Positives = 448/1155 (38%), Gaps = 199/1155 (17%) Query: 2617 EKEQVEIAEKNVLEK--EKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSN 2674 E+EQ++ + + E+ +++ L ++LLE K + EK+++R + V + E Sbjct: 189 EEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRK 248 Query: 2675 EESGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAE 2734 E+ E E L+ E + EL +E+ KL+ + L +E Q+ + R+ Sbjct: 249 RETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLR-REQQLR 307 Query: 2735 AKEKLSILEKEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNA 2794 K++ E+++E Q+ ++ E +L + + + L+ + + Sbjct: 308 RKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQ----- 362 Query: 2795 GIQINLQSECSSEEVTEIISQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQ 2854 Q+ + E EE E + +++ + Q+L + L E + + + L+RE Q Sbjct: 363 --QLRREQE---EERREQQLRREQQLRREQQLRREQQLRREQQ-LRREQQLRREQ----Q 412 Query: 2855 LLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREICSSDSGSDWGQGIYLTHSQGFD 2914 L +E+ L+ Q R +E + + + R + DW + Sbjct: 413 LRREQ--QLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLK----------- 459 Query: 2915 IASEGRGEESESATDSFPKKIKGLLRAVHNEGMQV-LSLTESPYSDGEDHSIQQVSEPWL 2973 E E+ ++ + L R E + L L E + ++ QQ+ Sbjct: 460 -------REEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQE 512 Query: 2974 EERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVL 3033 E R+ +L+R+ E Q S R E +Q+ E Sbjct: 513 ERRE---------------QRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREE--- 554 Query: 3034 LAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQM 3093 E+R++++ E + E ++ D Q L + Sbjct: 555 -----------------------EKRLEQERREQRLKREQEERRD--------QLLKREE 583 Query: 3094 NGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVV 3153 R+ LKREQE E LE +++++ + LE + R E E+ ++++ Sbjct: 584 ERRQQRLKREQE------ERLEQRLKREEVERLEQEERREQRLKR--EEPEEERRQQLLK 635 Query: 3154 AELKSELAQTKLELETTLKAQHKHLKELEAFRLE--VKDKTDEVHLLNDTLASEQKKSRE 3211 +E + E Q +L E + + + +E E RLE +K + +E + EQ+++RE Sbjct: 636 SEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARE 695 Query: 3212 L--------QWALEKEK-AKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLL 3262 QW LE E A+ + R +++ E Q++R Q ++K+ Sbjct: 696 RIKSRIPKWQWQLESEADARQSKVYSRPRKQ--------EGQRRRQEQ------EEKRRR 741 Query: 3263 NESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERE-LHAQLQSS 3321 ES+ + + + + Q EEQ R+ Q E + R R+ S RE QL++ Sbjct: 742 RESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAE 801 Query: 3322 DGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKL-----------DSLQT-- 3368 + + + LP E+ ++ ++Q E+ + + L E E+ + D LQ Sbjct: 802 ERQQREQRFLPEEEEKEQRRRQRREREKEL-QFLEEEEQLQRRERAQQLQEEEDGLQEDQ 860 Query: 3369 --------------RQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEK 3414 R Q+E++R+ R TL + + +K+ LQ + E+LQR+ EK Sbjct: 861 ERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREK 920 Query: 3415 --RQQVYKLDLEGQRLQGIMQEFQKQELEREEKRESRRIL----------YQNLNEPTTW 3462 RQ+ + E ++LQ ++ ++E E+ ++E R Q L E Sbjct: 921 RRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEK 980 Query: 3463 SLTSDRTRNWVLQQKIEGETK---------------ESNYAKLIEMNGGGTGCNHELEMI 3507 +R + + +++++ E + E Y K E+ E +++ Sbjct: 981 RRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQ------QEEEQLL 1034 Query: 3508 RQKLQCVASKLQVLPQKASERLQFETADDEDFIWVQE----NIDEIILQLQKLTGQQGEE 3563 R++ + K ++ ++ R + E +E+ + +E E+ Q +K Q EE Sbjct: 1035 REERE----KRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEE 1090 Query: 3564 PSLV--SPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKLEEQIRWYRQTGAG 3621 L+ P ER R+ EL QL E+ + R +LE Q R + Sbjct: 1091 EQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRR-QELERQYREEEEVQQE 1149 Query: 3622 RDNSSRF--SLNGGANIEAIIASEKEVWNREKLTLQKSLKRAEAE---VYKLKAELRNDS 3676 + R +E E+E+ E+ L++ ++ E Y+ + EL+ Sbjct: 1150 EEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQK 1209 Query: 3677 LLQTLSPDSEHVTLK 3691 Q + + LK Sbjct: 1210 RKQRYRDEDQRSDLK 1224 Score = 93.2 bits (230), Expect = 5e-18 Identities = 135/573 (23%), Positives = 240/573 (41%), Gaps = 59/573 (10%) Query: 3075 QKADRRSLLSEIQALHAQMNGRKITLKREQESE-------KPSQELLEYNIQQKQSQMLE 3127 Q+ D+R + L + R+ ++EQE E QE LE +Q++ + L Sbjct: 115 QEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELW 174 Query: 3128 MQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTK----LELETTLKAQHKHLKELEA 3183 Q + ++ +EQL S K E + Q + LEL + + + + Sbjct: 175 RQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQ 234 Query: 3184 FRLEVKDKTDEVHLLNDTLASEQKK--------SRELQWALEKEKAKLGRSE---ERDKE 3232 R+ +++ E L E++K RELQ E++ KL R E ER +E Sbjct: 235 DRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQ-EEEEQLRKLERQELRRERQEE 293 Query: 3233 ELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQV 3292 E + + E Q +R + +Q+++ E Q++ E Q + QL EQ E Q+ Sbjct: 294 EQQQQRLRREQQLRRKQEEERREQQEER--REQQERREQQEERREQQLRREQEERREQQL 351 Query: 3293 LLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIV 3352 E E+ R + E QL+ + + + L +E Q + E++ R Sbjct: 352 RREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQ 411 Query: 3353 ELLNETEKYKLDSLQTRQQMEKDRQVH-----RKTLQTEQE-----ANTEGQKKMHELQS 3402 +L E + + L+ Q+ E+ Q H + L+ EQE E + + HE + Sbjct: 412 QLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQER 471 Query: 3403 KVEDLQR-QLEEKRQQVYKLDLEGQRLQGIMQEFQKQELERE-EKRESRRILYQNLNEPT 3460 + + L+R Q EE+R++ KL+ E +R Q QE ++Q+L RE E+R +R+ Q E Sbjct: 472 RKQQLKRDQEEERRERWLKLEEEERREQ---QERREQQLRREQEERREQRLKRQEEEERL 528 Query: 3461 TWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMIRQKL--QCVASKL 3518 L S++ +++ E K K +E E E R +L + + Sbjct: 529 QQRLRSEQQLRREQEERREQLLKREE-EKRLEQERREQRLKREQEERRDQLLKREEERRQ 587 Query: 3519 QVLPQKASERLQFETADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSPSTSCGSLTE 3578 Q L ++ ERL+ +E E +++ + Q+L ++ EE + Sbjct: 588 QRLKREQEERLEQRLKREE-----VERLEQEERREQRLKREEPEE-----------ERRQ 631 Query: 3579 RLLRQNAELTGHISQLTEEKNDLRNMVMKLEEQ 3611 +LL+ + QL E+ + R +K EE+ Sbjct: 632 QLLKSEEQEERRQQQLRREQQERREQRLKREEE 664 Score = 89.0 bits (219), Expect = 9e-17 Identities = 136/659 (20%), Positives = 263/659 (39%), Gaps = 97/659 (14%) Query: 7 QKKLEAGKAKLAQFRQRKAQSDGQSPSKKQKKKRKTSSSKHDVSAHHDLNIDQSQCNEMY 66 +++LE + K A+ R RK+Q + Q +++++KR+ + L Sbjct: 1296 EEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQL----------- 1344 Query: 67 INSSQRVESTVIPESTIMRTLHSGEITSHEQGFSVELESEISTTADDCSSEVNGCSFVMR 126 Q E + R E+ EQG LE E + R Sbjct: 1345 ---LQEREEQPLRRQERDRKFREEELRHQEQGRKF-LEEE---------------QRLRR 1385 Query: 127 TGKPTNLLREEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHEIEELNRELEEMRVTYG 186 + L+EE+ +Q QD E +L+ ++ + + E + R Sbjct: 1386 QERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERE 1445 Query: 187 TEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLE----LTEQSQKLQIQF 242 + L++ Q+ ++ QL ++ + + E R+FLE L Q + + + Sbjct: 1446 RKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFRE 1505 Query: 243 QQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQ 302 Q+L++ E R Q +++ L +QQL Q+ + Q + F + Q Sbjct: 1506 QELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQ 1565 Query: 303 EKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGEL 362 E+ E +Q + E K ++E++ +E K +E+E++ + + +L E Sbjct: 1566 ER----EEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQ----QQLRQER 1617 Query: 363 QEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQF--ETDIVQ 420 + + Q ++ + + + ++++R+ EE QL E Q R+ +D +F E ++Q Sbjct: 1618 DRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQ 1677 Query: 421 RMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSN 480 E++ R R E D + ++ Q++++ + Q E+ R E+E R Sbjct: 1678 EGEEQQLR-----RQERDRKFREEEQQLRRQERERKFLQEEQQLRRQ--ELERKFR---- 1726 Query: 481 ITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFS 540 E+Q++ Q+T ++ + +E ILEE+ QL EE Sbjct: 1727 ---EEEQLR-------------QETEQEQLRRQERYRKILEEE-----QLRPEREEQQLR 1765 Query: 541 REQIQR-------ARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEV 593 R++ R RQ EQ+ + E+ + E L+ E R+E +L+ + Sbjct: 1766 RQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQE-------REEQQLRPQQRD 1818 Query: 594 TNYK-----IKLEMLEKEKNAVLDRM--AESQEAELERLRTQLLFSHEEELSKLKEDLE 645 Y+ ++LE E+ DR AE Q A E+ R + +EE K +++ E Sbjct: 1819 GKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERE 1877 Score = 79.3 bits (194), Expect = 7e-14 Identities = 109/488 (22%), Positives = 217/488 (44%), Gaps = 81/488 (16%) Query: 3057 EQRIQEQGVEYQAAMECLQKADRRSLL------SEIQALHAQMNGRKITLKREQESEKPS 3110 E+ +Q++ E Q E +K R+ L E+Q Q+ + +R QE E+ Sbjct: 1113 EEELQQE--EEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQY 1170 Query: 3111 QELLEYNIQQKQSQML-EMQVELSSMKDRA----TELQEQLSSEKMVVAELKSELA-QTK 3164 +E E +QQ++ Q+L E Q + ++R ELQ Q ++ + +S+L Q + Sbjct: 1171 RE--EEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWE 1228 Query: 3165 LELETTLKAQHKHLK--ELEAFRL----EVKDKTDEVHLLNDTLASEQKKSRELQ---WA 3215 E E ++ + K E E FR +++D+ + L + L +Q++ RE + W Sbjct: 1229 PEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQH-LLGEQQERDREQERRRWQ 1287 Query: 3216 -----------LEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNE 3264 LE+E+ K + +R +E + L +K+R + + +++QLL E Sbjct: 1288 QRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQE 1347 Query: 3265 SQQ----KIESQRMLYDAQLS-EEQGRNL------------ELQVLLESEKVRIREMSST 3307 ++ + E R + +L +EQGR E + L E +++R +E Sbjct: 1348 REEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQ 1407 Query: 3308 LDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQ 3367 L ++R+ + + + Q R E+ + +++ E K + L + K + Sbjct: 1408 LRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEE 1467 Query: 3368 TRQQMEKDRQVH-----RKTLQTEQE-ANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKL 3421 Q +++Q+H RK L+ EQ+ E +K E + + ++ +R+ E+ QQ+++ Sbjct: 1468 QLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHR- 1526 Query: 3422 DLEGQRLQGIMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGE 3481 QR + +QE +Q+L R+E+ + RR DR R + ++++ E Sbjct: 1527 ---QQRQRKFLQE--EQQLRRQERGQQRR---------------QDRDRKFREEEQLRQE 1566 Query: 3482 TKESNYAK 3489 +E ++ Sbjct: 1567 REEQQLSR 1574 Score = 36.2 bits (82), Expect = 0.65 Identities = 68/312 (21%), Positives = 121/312 (38%), Gaps = 43/312 (13%) Query: 3383 LQTEQEANTEGQ------KKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQ 3436 L E+ A +G+ ++ E Q + E RQLEE+ GQR + QE + Sbjct: 95 LDEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEE---------PGQRRRQKRQEQE 145 Query: 3437 KQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGG 3496 ++ E EE+ E + L Q + L R + W +++ E ++ K Sbjct: 146 RELAEGEEQSEKQERLEQRDRQRRDEELWRQR-QEWQEREERRAEEEQLQSCK------- 197 Query: 3497 GTGCNHELEMIRQKLQCVASKLQVLPQKASERLQFETADDEDFIWVQENID-----EIIL 3551 HE E + Q +L L +K E Q + + +D ++ +E E +L Sbjct: 198 ----GHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVL 253 Query: 3552 QLQKLTGQQGEEP----SLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMK 3607 + ++ Q+ EEP L L + LR+ + Q + LR K Sbjct: 254 RKEEEKLQE-EEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRR---K 309 Query: 3608 LEEQIRWYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRAEAEVYK 3667 EE+ R Q R+ R E + E+E ++L ++ +R E ++ + Sbjct: 310 QEEERR--EQQEERREQQERREQQEERR-EQQLRREQEERREQQLRREQEEERREQQLRR 366 Query: 3668 LKAELRNDSLLQ 3679 + E R + L+ Sbjct: 367 EQEEERREQQLR 378 >gi|41322923 plectin 1 isoform 11 [Homo sapiens] Length = 4547 Score = 192 bits (487), Expect = 7e-48 Identities = 274/1260 (21%), Positives = 544/1260 (43%), Gaps = 171/1260 (13%) Query: 1579 QLMLNEEQLEDMRQE---LVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNR 1635 +++ EE D +Q+ + + Q+ +Q++E QA RQ E + +++EEI+ + Sbjct: 1400 EVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRL 1459 Query: 1636 QLA----QRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNEN 1691 QL QR + E + R EE EA K+ + E+L ++++ S Q + Sbjct: 1460 QLEATERQRGGAEGE---LQALRARAEEAEAQKRQAQEEAERLRRQVQDES---QRKRQA 1513 Query: 1692 QGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGR 1751 + E+ + E E R+ + + L R ++A RL + +E + ET Sbjct: 1514 EVELASRVKAEAEAAREKQRAL-QALEELRLQAEEAERRLRQAEVERARQVQVALETA-- 1570 Query: 1752 HVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMW 1811 RS++++ + +E A ++ + EEH V Sbjct: 1571 ------QRSAEAELQSKRASFAEKTAQLERSLQEEHVAV--------------------- 1603 Query: 1812 SKVTEEGTELSQRLVRSGFAGTEIDPENE--ELMLNISSRLQAAVEKLLEAISETSSQLE 1869 +++ EE +Q+ + A E + E E +L N + RL+ E++ + S ++ E Sbjct: 1604 AQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE 1663 Query: 1870 HAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYAD 1929 K E RE+ R+ + ++++ +E + L ++ + E A + AE + Sbjct: 1664 KQK---EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRA 1720 Query: 1930 EKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELL------------- 1976 E E+Q Q + + RL++E A+ + QELEAE +++ E E+L Sbjct: 1721 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS 1780 Query: 1977 --SRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQV 2034 + K+ ++AEAG ++L +E +L E + Q + +D +Q E + E++ Sbjct: 1781 TSEKSKQRLEAEAGRF-RELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKL 1839 Query: 2035 SRFIE---LEQEKNTELMDLRQQNQALEKQLEK---MRKFLDEQAIDREHERDVFQQEIQ 2088 + E L+ E L + +N+ L + E R+ L+EQA +H+ D+ ++ Q Sbjct: 1840 AAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA--AQHKADIEERLAQ 1897 Query: 2089 KLEQQLKVVPRFQPISE---HQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEE 2145 + + R + + E Q R+VE+ LK +K + K +L+ ++ Sbjct: 1898 LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAA---AGKAELELELGRIRSN 1954 Query: 2146 IEKLEFRVRELEQALLVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLE 2205 E +R EQA L R+ A E + + R+A +R +K + EE Sbjct: 1955 AED---TLRSKEQAELEAARQRQLAAEEE---------RRRREAEERVQKSLAAEEEAAR 2002 Query: 2206 QFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMST 2265 Q + L EEV++L ++E ++ QE ++ +L ++ +K A +++ A + Sbjct: 2003 QRKAAL----EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAV 2058 Query: 2266 QDQHVLFGKFAQIIQEKEVEIDQLNEQV------------TKLQQQLKITTDNKVIEEKN 2313 Q + + Q +Q+++ +DQL + ++Q + + + +EE Sbjct: 2059 QQKE---QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAE 2115 Query: 2314 ELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEA 2373 L + E Q + Q ++ R+E + E + Q E A + QK + +A E Sbjct: 2116 RLKQSAEEQAQARAQAQAAAEKLRKEAEQ---EAARRAQAEQAALRQKQAADA-----EM 2167 Query: 2374 DSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVE 2433 + K + + +K +EQ E+T ++ L+ET+ + N L +EL LK E Sbjct: 2168 EKHKKFAEQTLRQKAQVEQ-------ELTTLRLQLEETDHQKNLLDEELQRLKAEATEAA 2220 Query: 2434 KIQSIPEN---SVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLE 2490 + +S E SV V ++ LSK K +E L+ +N F EE K + E Sbjct: 2221 RQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQ-EEAEKMKQVAEE 2279 Query: 2491 TRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQ 2550 L + + +A+ +L + +D+ +Q +ML++K+ +Q+ K A L+ Q Sbjct: 2280 AARLSVAAQEAARLRQLAE-----EDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQ 2334 Query: 2551 IQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQL------REDELGSDISALTLRISEL- 2603 Q E QE A+ Q+++ ++ Q + R+ E+ ++ L LR++E+ Sbjct: 2335 -QKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMS 2393 Query: 2604 -----------------ESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNE 2646 E ++H + + +E+V + + +++++ + ++L E Sbjct: 2394 RAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIA 2453 Query: 2647 KKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAEL-------AS 2699 + +REKEK + Q+ ++L+ +E + ++ E +AL+ ++ K L Sbjct: 2454 ELEREKEKLQ--QEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQ 2511 Query: 2700 YKEKAEKLQEELLVKETNMTS----LQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKK 2755 K K E+L ++ + K + Q+ + Q R L + E+ + E E V+ ++ Sbjct: 2512 EKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQE 2571 Score = 171 bits (433), Expect = 1e-41 Identities = 345/1688 (20%), Positives = 693/1688 (41%), Gaps = 223/1688 (13%) Query: 1837 PENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQ 1896 PE + S L+ + KL + S ++ LE K + R Q A E L+ Sbjct: 1054 PEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVI-----RGTQGAEEVLRAH 1108 Query: 1897 EELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCAS 1956 EE + +E AV + E + +K + + Q+ T D L EL A Sbjct: 1109 EE---------QLKEAQAVPATLPELEATKASLKKLRAQAEAQQPT--FDALRDELRGA- 1156 Query: 1957 NRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVR 2016 QE+ QQ ER++ + A+ Q +L +T+ +E ++ Q R Sbjct: 1157 ---QEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYR 1213 Query: 2017 DDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDE-QAID 2075 + L+ D + + + + + + +Q QAL +++E+ + ++E Q Sbjct: 1214 ESADPLGAWLQ-DARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFA 1272 Query: 2076 REHERDVFQQEIQKL--EQQLKVV------PRFQPISEHQTREVEQLANHLKEKTDKCSE 2127 +++ + E+Q + + QL+ V P+ Q SE +E L H E T S+ Sbjct: 1273 KQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQ 1332 Query: 2128 LL--LSKEQLQRDIQERNEEIEKLEFRVRELEQALLVEDRKHFGAVEAKPELSLEVQLQA 2185 + +S+ + + +ER E ++ E R R E +E ++ A + + QA Sbjct: 1333 YIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHA------QAKAQA 1386 Query: 2186 ERDAID---RKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQE 2242 ER+A + R ++E+ EE +++ + EE+QQL E + + + + E+ Sbjct: 1387 EREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERS 1446 Query: 2243 NKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKI 2302 ++++ + L ++ ++ + L A+ +E E + Q E+ +L++Q Sbjct: 1447 RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARA-EEAEAQKRQAQEEAERLRRQ--- 1502 Query: 2303 TTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKT 2362 ++++++ R E ++ + + R ++ ++ L E+ +LQ Sbjct: 1503 ------VQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL--RLQ---------- 1544 Query: 2363 SMNAHSLSEEADSLKHQLDVVIAEKL--ALEQQVETANEEMTFMKNVLKETNFKMNQLTQ 2420 +EEA+ Q +V A ++ ALE +A E+ + E ++ + Sbjct: 1545 -------AEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLER--- 1594 Query: 2421 ELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEE 2480 SL+ E +V +++ E + + + E E L LK+ E Sbjct: 1595 ---SLQEEHVAVAQLREEAERRAQQQAE-AERAREEAERELERWQLKANEA--------- 1641 Query: 2481 NGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQ----GQFETEMLQKKIVNLQ 2536 L RL Q E K L + KQ ++ + + G+ E + ++++ + Q Sbjct: 1642 --------LRLRL-QAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1692 Query: 2537 KIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGS---DI 2593 ++ +++ A +Q +L A QE + + +E E+ Q QL E+EL + Sbjct: 1693 ELEKQRQLAEGTAQQRLAAEQELIR-------LRAETEQGEQQR--QLLEEELARLQREA 1743 Query: 2594 SALTLRISELESQVVEMHTS---LILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQR 2650 +A T + ELE+++ ++ L+ K + E ++ EK K+ LE E ++ Sbjct: 1744 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA----EAGRFREL 1799 Query: 2651 EKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALR--AESVATKAELASYKEKAEKLQ 2708 +E R E K +L EE EA R AE +A E K +AE Sbjct: 1800 AEEAARLRALAEEAKRQRQLA---EEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIAL 1856 Query: 2709 EELLVKETNMTSLQKDLS--------QVRDHLAEAKEKLSILEKEDETEVQESK------ 2754 +E + + L +D + Q H A+ +E+L+ L K ++E++ K Sbjct: 1857 KEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDT 1916 Query: 2755 ----KACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVT 2810 + E L +K S A+ L++ I+ N + S+E Sbjct: 1917 LRQRRQVEEEILALKASFEKAAAGKAELELELGR-----------IRSNAEDTLRSKEQA 1965 Query: 2811 EIISQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCL 2870 E+ + ++ +E E + + ++ E R+ A+ EE LKA ++ Sbjct: 1966 ELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL----EEVERLKAKVEEA 2021 Query: 2871 R------SKEGSSIPELAHSDAY---QTREICSSDSGSDWGQGIYLTHSQGFDIASEGRG 2921 R +E + +LA A Q E + + Q + T Q + + RG Sbjct: 2022 RRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRG 2081 Query: 2922 EESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYIN 2981 E +E+A + A E +V + E+ S + +++ + E+ +A Sbjct: 2082 E-AEAARRA----------AEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQ 2130 Query: 2982 TISSLKDLITKMQLQ--REAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRT 3039 ++ + L + + + R A+ ++ + +D E + L +++ + T Sbjct: 2131 AQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTT 2190 Query: 3040 ELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADR-----RSLLSEIQALHAQMN 3094 L TD N L++ +Q E A + + R + E+ L A++ Sbjct: 2191 LRLQLEETDHQK--NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIE 2248 Query: 3095 G--RKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATEL---------Q 3143 R + L+ + +++ QE E K Q+ E LS A L Q Sbjct: 2249 AENRALILRDKDNTQRFLQEEAE-----KMKQVAEEAARLSVAAQEAARLRQLAEEDLAQ 2303 Query: 3144 EQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLA 3203 ++ +EKM+ ++++ T+L+ E L Q K L + +A RL+ + L +T Sbjct: 2304 QRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQG 2363 Query: 3204 S----EQKKSRELQWALEKEKAKL-----GRSEERDKEELEDLKFSLESQKQRNLQLNLL 3254 E ++ R+L+ + E E+ KL R++ R +E+ + + E ++ L L Sbjct: 2364 FQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEK-LHRTEL 2422 Query: 3255 LEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDREREL 3314 Q+K L ++ + I+ Q+ +DA+ E LE + ++ ++ ++ S + + Sbjct: 2423 ATQEKVTLVQTLE-IQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQ 2481 Query: 3315 HAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNE----TEKYKLDSLQTRQ 3370 LQ + QS L +D L + ++ +E++ +++ +L + ++ + + + +Q Sbjct: 2482 EQLLQETQALQQSF--LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQ 2539 Query: 3371 QMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQG 3430 QME++RQ + + + +EA + ++ K E+LQ+ +++RQQ L E QRL+ Sbjct: 2540 QMEQERQ---RLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLRE 2596 Query: 3431 IMQEFQKQ 3438 +Q ++Q Sbjct: 2597 QLQLLEEQ 2604 Score = 158 bits (399), Expect = 1e-37 Identities = 323/1676 (19%), Positives = 685/1676 (40%), Gaps = 242/1676 (14%) Query: 153 SPTHLEMMESELAGKQHEIEELNR-ELEEMR----VTYGTEGLQQ-LQEFEAAIKQRDGI 206 +PT +E L GK ++ L+ LE+++ V GT+G ++ L+ E +K+ + Sbjct: 1060 APTLRSELELTL-GKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAV 1118 Query: 207 ITQLT------ANLQQARREKDETMREFLELTEQ---SQKLQIQFQQLQASETLRNSTHS 257 L A+L++ R + + F L ++ +Q++ + QQ + Sbjct: 1119 PATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWR 1178 Query: 258 STAADLLQAKQQILTH----QQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQD 313 A LL+ Q +L Q++LE+ L Y++ + ++LQ+ + E Q Sbjct: 1179 ERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLG---AWLQDARRRQEQIQA 1235 Query: 314 KKVENSN--KEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQ 371 + +S +E++++++ ++EE+ +K E + + + + Q+V Sbjct: 1236 MPLADSQAVREQLRQEQALLEEIE----RHGEKVEECQRFAKQYINAIKDYELQLVTYKA 1291 Query: 372 EIKNMKLELTNSKQKERQSS--EEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRK 429 +++ + K + S +E L EL + +F ++ ++RME+E +R Sbjct: 1292 QLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEE-ERL 1350 Query: 430 LEQLRAE-----------------LDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEME 472 EQ RAE L E + Q Q ++E EE+ R + ++ Sbjct: 1351 AEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVD 1410 Query: 473 NALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKE---KLKEELGLI---LE----- 521 + S + E+ +L + E+ K + + + +++EE+ ++ LE Sbjct: 1411 AQQQKRS---IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQ 1467 Query: 522 ------EKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEI 575 E AL+ + E+ + ++E+ +R R+ + ++ + +A L++ +KAE Sbjct: 1468 RGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELAS--RVKAEA 1525 Query: 576 VSASESRKEL----ELKHEAEVTNYKIKLEMLEKEK--NAVLDRMAESQEAELERLRTQL 629 +A E ++ L EL+ +AE +++ +E+ + L+ S EAEL+ R Sbjct: 1526 EAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRA-- 1583 Query: 630 LFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDG--LQNEMSQKIETMQFEKDN 687 S E+ ++L+ L+ EH + + +L++ +QQ + + E +++E Q + + Sbjct: 1584 --SFAEKTAQLERSLQEEH-VAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANE 1640 Query: 688 LITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTL-EQEVQ 746 + + Q E+++ K L Q+ E +K+ E +E + +G EQ V+ Sbjct: 1641 ALRLRLQ-AEEVAQQKSLAQA--------------EAEKQKEEAEREARRRGKAEEQAVR 1685 Query: 747 ELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFL 806 + +L + LEKQ + E Q++ A AE +++ L+ T +++R + Sbjct: 1686 QRELAEQELEKQRQLAEGTAQQRLA---AEQELIR---------LRAETEQGEQQRQLLE 1733 Query: 807 DSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEI-----------EKQRNTFSFAEK 855 + + + ++E ++ ++L+ + ++ E+ E+ R+T +++ Sbjct: 1734 EEL------ARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQ 1787 Query: 856 NFEV---NYQELQEEYACLLKVKDD-------LEDSKNKQELEYK----SKLKALNEELH 901 E ++EL EE A L + ++ E+ +Q E + KL A+ E Sbjct: 1788 RLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATR 1847 Query: 902 LQRINPTTVKMKSSVFD------EDKTFVAETLEMGEVVEKDTTELMEKL-EVTKREKLE 954 L+ +K K + + ED+ F LE E + ++ E+L ++ K E Sbjct: 1848 LKTEAEIALKEKEAENERLRRLAEDEAFQRRRLE--EQAAQHKADIEERLAQLRKASDSE 1905 Query: 955 LSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDT 1014 L ++ + + L+Q+ + EE+ +LK E+ + ELE+ + R+ + + Sbjct: 1906 LERQKGLVEDTLRQRRQ----VEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS 1961 Query: 1015 QVSSLLDG-----VVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQ 1069 + + L+ + R + +V KS E + + K + E + + +E Sbjct: 1962 KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 2021 Query: 1070 LILDHLPSVTKESSLRATQPSENDKLQKE--LNVLKSEQNDLRLQMEAQRICLSLVYSTH 1127 L L+ Q + +LQ E + +Q + LQ Q+ + Sbjct: 2022 RRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ------EQSV 2075 Query: 1128 VDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLL 1187 +DQ+R E + +A +E + A+ E + +++ + E +E Sbjct: 2076 LDQLRGEAEAAR-RAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAA 2134 Query: 1188 IGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRY 1247 KL+K +E + Q + L + + E + + E Q R Sbjct: 2135 AEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE--------------QTLRQ 2180 Query: 1248 EVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSI 1307 + Q QE + TL ++ E ++ +L L ++ + T+ + + E E S+ Sbjct: 2181 KAQVEQE-LTTLRLQLEETDHQKNLLDEELQRLKAEATEAAR------QRSQVEEELFSV 2233 Query: 1308 HSQMTNLEDID--VNHKSKLSSLQDLEKTK--LEEQVQELESL------ISSLQQQLKET 1357 QM L + + +++ L+D + T+ L+E+ ++++ + +S Q+ Sbjct: 2234 RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARL 2293 Query: 1358 EQNYEAEI--------HCLQKRLQAVSEST---VPPSLPVDSVVITESDAQRTMYPGSCV 1406 Q E ++ L++++QAV E+T L + + A+R + Sbjct: 2294 RQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM 2353 Query: 1407 KKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISG 1466 + + +E + LE + Q QLE + + +A E+SR Sbjct: 2354 AQQL-----------AEETQGFQRTLEAERQRQLEMSAEAERLKLRVA-----EMSRAQA 2397 Query: 1467 GKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGK 1526 E A + A E+ + E+ + QT E + + + L + + E + Sbjct: 2398 RAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELER 2457 Query: 1527 EILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQ 1586 E + + + + T+ +E ++ T ++QS E S + R + + + Sbjct: 2458 EKEKLQQEAKLLQLKSEEMQTVQQEQLLQE-TQALQQSFLSE-KDSLLQRERFIEQEKAK 2515 Query: 1587 LEDM-------RQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQ 1639 LE + Q+L + Q QQ E RQ + ME R Q + +E ++R +L Q Sbjct: 2516 LEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQ 2575 Query: 1640 --RSSIDNENLVSERERVLLEELEALKQ---LSLAGREKLCCELRNSSTQTQNGNE 1690 + E L++E + L E+L+ L++ +LA E++ ++ NG + Sbjct: 2576 LEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRD 2631 Score = 151 bits (382), Expect = 1e-35 Identities = 318/1657 (19%), Positives = 679/1657 (40%), Gaps = 234/1657 (14%) Query: 1992 QQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDL 2051 QQLLQ E+ +E+ Q +++D ++ Q++A E ++ + L++E E Sbjct: 966 QQLLQSLEQGAQEESRCQRCISELKD-IRLQLEACETRTVHRLR--LPLDKEPARECAQR 1022 Query: 2052 RQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREV 2111 + Q + ++E + K + + + E ++ L + P + E ++ Sbjct: 1023 IAEQQKAQAEVEGLGKGVARLSAEAE--------KVLALPEPSPAAPTLRSELELTLGKL 1074 Query: 2112 EQLANHLKEKTDKCSELLL------SKEQLQRDIQERNEEIEKLEFRVRELEQALLVEDR 2165 EQ+ + +K + L E++ R +E+ +E + + + ELE + Sbjct: 1075 EQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKK 1134 Query: 2166 KHFGAVEAKPEL-SLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQ 2224 A +P +L +L+ ++ +R ++ + ++E++RE + E Q + Q Sbjct: 1135 LRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQ 1194 Query: 2225 LEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEV 2284 +++++E L++L ++ + +++ + LG ++++ Q Q + +Q ++E+ Sbjct: 1195 TDVRQRE----LEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLAD-SQAVREQLR 1249 Query: 2285 EIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRN-REEEIEQ 2343 + L E++ + + K+ + ++ I+D E Q+ + E V ++ +++ Sbjct: 1250 QEQALLEEIERHGE--KVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQS 1307 Query: 2344 LNE-VIEKLQQELANIGQKTSMNAHSLS---------EEADSLKHQLDVVIAEKLA---- 2389 +E VI++ + + T++ + + EE + L Q E+LA Sbjct: 1308 GSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEA 1367 Query: 2390 -LEQQVETANEEMTFMKNVLKETNFKMNQLTQELF--------SLKRERESVEKIQSIPE 2440 LE+Q + A +E ++ +E+ + +++R E++Q + + Sbjct: 1368 ALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQ 1427 Query: 2441 NS-VNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENG-KGSIINLETRLLQLES 2498 +S + + E + E+ ++ + Q + G +G + L R + E+ Sbjct: 1428 SSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEA 1487 Query: 2499 TVSAKDLELTQCYKQIKD-MQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQ 2557 E + +Q++D Q + Q E E+ + + E++ A + +++L+A + Sbjct: 1488 QKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQA-E 1546 Query: 2558 EYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILE 2617 E + + + + + ++ + E EL S ++ + ++LE + E H ++ Sbjct: 1547 EAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQL 1606 Query: 2618 KEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREK----------EKKRSPQDVEVLKTT 2667 +E+ E + E E+ E ++ LE + K E +++S E K Sbjct: 1607 REEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK 1666 Query: 2668 TELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQ 2727 E G E +A+R +A + EL ++ AE ++ L E + L+ + Q Sbjct: 1667 EEAEREARRRGKAEE-QAVRQRELAEQ-ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQ 1724 Query: 2728 VRDHLAEAKEKLSILEKEDETEVQ-----ESKKACMFEPLPIKLSKSIASQTDGTLKISS 2782 +E+L+ L++E Q E++ A + + + L+ ++ + S+ Sbjct: 1725 GEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR---ST 1781 Query: 2783 SNQTPQILVKNAGIQINLQSECSS----EEVTEIISQFTEKIEKMQELHAAEILDMESRH 2838 S ++ Q L AG L E + E + Q E+ Q A +L + Sbjct: 1782 SEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAA 1841 Query: 2839 ISETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREI------ 2892 I E LK E +A LKE + E + LA +A+Q R + Sbjct: 1842 IGEATRLKTEAEIA---LKE------------KEAENERLRRLAEDEAFQRRRLEEQAAQ 1886 Query: 2893 -------------CSSDSGSDWGQGIY--------------LTHSQGFDIASEGRGEES- 2924 +SDS + +G+ L F+ A+ G+ E Sbjct: 1887 HKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELEL 1946 Query: 2925 ------ESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVS--EPWLEER 2976 +A D+ K + L A Q+ + E + E+ + ++ E +R Sbjct: 1947 ELGRIRSNAEDTLRSKEQAELEAARQR--QLAAEEERRRREAEERVQKSLAAEEEAARQR 2004 Query: 2977 KAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLA--------------- 3021 KA + + LK + + + RE +S++ + + + L A Sbjct: 2005 KAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQE 2064 Query: 3022 LQQVFLEERSVL------------------LAAFRTELTALGTTDAVGLLNCLEQRIQEQ 3063 LQQ +E+SVL A + E A + V L+Q +EQ Sbjct: 2065 LQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQ 2124 Query: 3064 G---VEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQ 3120 + QAA E L+K + QA A + ++ ++ +K +++ L Q Sbjct: 2125 AQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQV 2184 Query: 3121 KQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKE 3180 +Q ++ ++++L + L E+L K E + +Q + EL +++ Q + L + Sbjct: 2185 EQ-ELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEEL-FSVRVQMEELSK 2242 Query: 3181 LEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEK---------EKAKLGRSEERDK 3231 L+A R+E +++ + ++T Q+++ +++ E+ E A+L + E D Sbjct: 2243 LKA-RIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDL 2301 Query: 3232 EELEDLKFSLESQKQRNLQLNL-------LLEQQKQLLNESQQKIESQRMLYDAQLSEE- 3283 + L + +K + +Q LL+QQK+L E ++++ + QL+EE Sbjct: 2302 AQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEET 2361 Query: 3284 QG----------RNLELQVLLESEKVRIREMSSTLDR-ERELHAQLQSSDGTGQS--RPP 3330 QG R LE+ E K+R+ EMS R E + + ++ G+ R Sbjct: 2362 QGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTE 2421 Query: 3331 LPSEDLLK-----ELQKQ-----LEEKHSRIVELLNETEKY---------KLDSLQTRQQ 3371 L +++ + E+Q+Q E I EL E EK K + +QT QQ Sbjct: 2422 LATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQ 2481 Query: 3372 ME--KDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDL--------QRQLEEKRQQVYKL 3421 + ++ Q +++ +E+++ + ++ + + ++K+E L Q+ EE+++Q ++ Sbjct: 2482 EQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQM 2541 Query: 3422 DLEGQRLQGIMQEFQKQELEREEKRESRRILYQNLNE 3458 + E QRL M+E ++++ E EE ++ Q L + Sbjct: 2542 EQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQ 2578 Score = 147 bits (370), Expect = 3e-34 Identities = 322/1585 (20%), Positives = 651/1585 (41%), Gaps = 255/1585 (16%) Query: 1858 LEAISETSSQLEHAKVTQTELMRESFRQKQEATESLK--------CQEELRERLHEESRA 1909 L+ Q++ + ++ +RE RQ+Q E ++ CQ ++ ++ Sbjct: 1223 LQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY 1282 Query: 1910 REQLAVELSK----------------AEGVIDGYADEKT-------LFERQIQEKTDIID 1946 QL ++ +E VI Y D +T L + I+ ++ + Sbjct: 1283 ELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLR 1342 Query: 1947 RLEQELLCASN-------RLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETE 1999 R+E+E A RL E+EA ++ ++ E ++ K + EA ++Q++ +E Sbjct: 1343 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1402 Query: 2000 KLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEK---NTELMDLRQQNQ 2056 + + ++ Q Q ++++LQ+ ++ E +++ + + E+ + E+ +R Q + Sbjct: 1403 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE 1462 Query: 2057 ALEKQ---LEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQ 2113 A E+Q E + L +A + E ++ Q+E ++L +Q+ Q S+ + + + Sbjct: 1463 ATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQV------QDESQRKRQAEVE 1516 Query: 2114 LANHLKEKTDKCSE---LLLSKEQLQRDIQERNEEIEKLEF-RVRELEQALLVEDRKHFG 2169 LA+ +K + + E L + E+L+ +E + + E R R+++ AL R Sbjct: 1517 LASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA 1576 Query: 2170 AVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLE---QFREELENKNEEVQQLHMQLE 2226 +++K E Q ER ++ + + L E+ E Q + E E EE ++ + + Sbjct: 1577 ELQSKRASFAEKTAQLER-SLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ 1635 Query: 2227 IQKKESTT-RLQ--ELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKE 2283 ++ E+ RLQ E+ Q+ L + + EK KE + + GK +E+ Sbjct: 1636 LKANEALRLRLQAEEVAQQKSLAQAEAEKQ----KEEAEREARRR----GK----AEEQA 1683 Query: 2284 VEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQ 2343 V +L EQ + Q+QL T + + + ELIR L ++ E E++ + Sbjct: 1684 VRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR--------LRAETE----QGEQQRQL 1731 Query: 2344 LNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTF 2403 L E + +LQ+E A QK L E ++ +++V++A K E++ + +E+ Sbjct: 1732 LEEELARLQREAAAATQKRQ----ELEAELAKVRAEMEVLLASKARAEEESRSTSEKS-- 1785 Query: 2404 MKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVN--------------VAIDH 2449 K L+ + +L +E L+ E ++ + + E AI Sbjct: 1786 -KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGE 1844 Query: 2450 LSKDKPELEVVLTE-----DALKSLENQTYF--KSFEENGKGSIINLETRLLQLESTVSA 2502 ++ K E E+ L E + L+ L F + EE ++E RL QL A Sbjct: 1845 ATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRK---A 1901 Query: 2503 KDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKF 2562 D EL + ++D Q + ++++I+ L+ E+ A +++L ++ A+ Sbjct: 1902 SDSELERQKGLVEDTLRQRR----QVEEEILALKASFEKAAAGKAELELELGRIRSNAE- 1956 Query: 2563 CQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVE 2622 T+ S+ + L R+ +L ++ R E E +V + SL E+E Sbjct: 1957 ----DTLRSKEQA----ELEAARQRQLAAEEER---RRREAEERVQK---SLAAEEEAAR 2002 Query: 2623 IAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNE 2682 K LE+ ++L K ++ RE+ ++ S + +++ + + Sbjct: 2003 -QRKAALEEVERL----KAKVEEARRLRERAEQESARQLQLAQEAAQ------------- 2044 Query: 2683 LEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSIL 2742 + L+AE KA + ++K ++LQ+ L +++ + L+ + R EA+E Sbjct: 2045 -KRLQAEE---KAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQA 2100 Query: 2743 EKE---DETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQIN 2799 E+E +V+E+++ + + + K + + + A ++ Sbjct: 2101 EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK 2160 Query: 2800 LQSECSSEEVTEIISQ-FTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLLKE 2858 ++ E+ + Q +K + QEL + + ET+ K LL E Sbjct: 2161 QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRL------QLEETDHQKN-------LLDE 2207 Query: 2859 ECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIASE 2918 E LKA +++ S + E S Q E+ + I +E Sbjct: 2208 ELQRLKAEAT-EAARQRSQVEEELFSVRVQMEELSKLKAR----------------IEAE 2250 Query: 2919 GRGE--ESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEER 2976 R + T F ++ ++ V E ++ + E ++Q++E L ++ Sbjct: 2251 NRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQ------EAARLRQLAEEDLAQQ 2304 Query: 2977 KAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAA 3036 +A K L KMQ +EA + LL Q+ +E++ L Sbjct: 2305 RALAE-----KMLKEKMQAVQEATRLKAEAE-----------LLQQQKELAQEQARRLQE 2348 Query: 3037 FRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGR 3096 + ++ + G LE Q Q +E A E L+ R + +S QA A+ + + Sbjct: 2349 DKEQMAQQLAEETQGFQRTLEAERQRQ-LEMSAEAERLKL--RVAEMSRAQA-RAEEDAQ 2404 Query: 3097 KITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAEL 3156 + + E+ EK + E Q+K + + ++++ A L+E +AEL Sbjct: 2405 RFRKQAEEIGEKLHRT--ELATQEKVTLVQTLEIQRQQSDHDAERLRE-------AIAEL 2455 Query: 3157 KSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWAL 3216 + E + KL+ E L LK E ++ + E L + SE+ + + + Sbjct: 2456 ERE--KEKLQQEAKLL----QLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFI 2509 Query: 3217 EKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLY 3276 E+EKAKL + + + + + L+ + Q+Q+ +EQ++Q L S + E++R + Sbjct: 2510 EQEKAKLEQLFQDEVAKAQQLREEQQRQQQQ-------MEQERQRLVASME--EARRRQH 2560 Query: 3277 DAQ----LSEEQGRNLELQ-----VLLESEKVRIREMSSTLDRERE---LHAQLQSSDGT 3324 +A+ +E+ + LE Q LL E R+RE L+ + H++ ++ Sbjct: 2561 EAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQV 2620 Query: 3325 GQSRPPLPSEDLLKELQKQLEEKHS 3349 ++ D L + E +HS Sbjct: 2621 AATKTLPNGRDALDGPAAEAEPEHS 2645 Score = 141 bits (356), Expect = 1e-32 Identities = 365/1881 (19%), Positives = 749/1881 (39%), Gaps = 298/1881 (15%) Query: 417 DIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALR 476 DI ++E R + +LR LD+ ++ Q + Q AQ E+E + Sbjct: 991 DIRLQLEACETRTVHRLRLPLDKEPARECAQ---RIAEQQKAQ---------AEVEGLGK 1038 Query: 477 SYSNITVNEDQIKLM---NVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQ---RQL 530 + ++ +++ + + A L +L+ T + E+++ + LE+ + R Sbjct: 1039 GVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGT 1098 Query: 531 EDLVEELSFSREQIQRARQ---TIAEQES------KLN-EAHKSLSTVEDLKAEIVSASE 580 + E L EQ++ A+ T+ E E+ KL +A T + L+ E+ A E Sbjct: 1099 QGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQE 1158 Query: 581 SRKELELKH---EAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEEL 637 + L+ +H + EV ++ ++ L + AVL + + ++ ELE+L QL + E Sbjct: 1159 VGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQ-TDVRQRELEQLGRQLRYYRESAD 1217 Query: 638 ---SKLKEDLEIEHRINIEKLKDNLGIHYK-QQIDGLQNEMS---QKIETMQ-FEKDNLI 689 + L++ + +I L D+ + + +Q L E+ +K+E Q F K + Sbjct: 1218 PLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYIN 1277 Query: 690 TKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQE----V 745 ++ + ++ L+ +K ++ + +E LR E TL + + Sbjct: 1278 AIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFI 1337 Query: 746 QELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIF 805 E + E E+ +++ + +E+ A++EA L+ +++ E + +E + Sbjct: 1338 SETLRRMEEEERLAEQQRAEERERLAEVEAA---LEKQRQLAEAHAQAKAQAEREAK--- 1391 Query: 806 LDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQ 865 ++ + ++ V +E E D +QQ + EE+++ R + +E + ++ + Sbjct: 1392 --ELQQRMQEEVVRRE-----EAAVDAQQQKRSIQEELQQLRQS---SEAEIQAKARQAE 1441 Query: 866 EEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVA 925 L++++++ + + E + + A E LQ + + + A Sbjct: 1442 AAERSRLRIEEEIRVVRLQLEATERQRGGAEGE---LQALRARAEEAE-----------A 1487 Query: 926 ETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQ 985 + + E E+ ++ ++ + ++ ++EL+ R+ +E ++K + L E L+ Sbjct: 1488 QKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE----LRL 1543 Query: 986 EKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEE 1045 + E+ R R+ E+ RA VQ + R AE + SF E+ Sbjct: 1544 QAEEAERRLRQAEV----ERARQVQVA-----------LETAQRSAEAELQSKRASFAEK 1588 Query: 1046 SKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSE 1105 + + E S QE+ + + + +E+ RA Q +E ++ ++E +E Sbjct: 1589 TAQL-------------ERSLQEEHVA--VAQLREEAERRAQQQAEAERAREE-----AE 1628 Query: 1106 QNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIH 1165 + R Q++A + + V Q + + E +K +EE +E ++ Sbjct: 1629 RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQ-----------KEEAEREARRRG 1677 Query: 1166 QLELQTMKTQETGDEG--KPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVN 1223 + E Q ++ +E ++ K L G Q+ ++ E L+ E Sbjct: 1678 KAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELI--------------RLRAETE 1723 Query: 1224 AEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQ 1283 +++ + E E LQ ++ + L KV E LL SK + Sbjct: 1724 QGEQQRQ---LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLA-----SKARAE 1775 Query: 1284 QTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQEL 1343 + E ++ L E F + + L + K + + L + Q E Sbjct: 1776 EESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ----RQLAEEDAARQRAEA 1831 Query: 1344 ESLISSLQQQLKE-TEQNYEAEIHCLQK-----RLQAVSESTVPPSLPVDSVVIT-ESDA 1396 E +++ + E T EAEI +K RL+ ++E ++ ++D Sbjct: 1832 ERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI 1891 Query: 1397 QRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFA 1456 + + + ++K D +E + G+ E+T + + Q+EEE+ + S A A Sbjct: 1892 EERL---AQLRKASDSELE--RQKGLVEDT-------LRQRRQVEEEILALKASFEKAAA 1939 Query: 1457 QQTELS----RISGGKENTASSK---------QAHAVCQQEQHY------------FNEM 1491 + EL RI E+T SK Q ++E+ E Sbjct: 1940 GKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 1999 Query: 1492 KLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDI--PESKDCVLTIS 1549 Q + + E + K +E + + E +++ L+ E K + Sbjct: 2000 AARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQ 2059 Query: 1550 EEMFSKDKTFIVRQSIHDEISVSSMDASR--------QLMLNEEQLEDMRQ----ELVRQ 1597 ++ +T QS+ D++ + A R ++ E + RQ E ++Q Sbjct: 2060 QKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQ 2119 Query: 1598 YQEHQQATELLRQAHMRQMERQREDQ--EQLQEEIKRLNRQLAQRSSIDNENLVSE---R 1652 E Q QA ++ ++ E + + Q E L ++ A + ++ +E R Sbjct: 2120 SAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLR 2179 Query: 1653 ERVLLE-ELEALK-QLSLAGREK--LCCELRNSSTQTQNGNENQGEVEEQTFKEKELDRK 1708 ++ +E EL L+ QL +K L EL+ + + +VEE+ F + + Sbjct: 2180 QKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE 2239 Query: 1709 PEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSAS 1768 + I + R + + + + L E + V E R S +Q +A Sbjct: 2240 LSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAAR-------LSVAAQEAAR 2292 Query: 1769 LIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRS 1828 L +E + + + + E+ + +++ + + +++ ++ EL+Q R Sbjct: 2293 LRQLAEEDLAQQRALAEKMLKEKMQAVQEATR-------LKAEAELLQQQKELAQEQAR- 2344 Query: 1829 GFAGTEIDPENEELMLNISSRLQAAVEKLLEAIS----ETSSQLEHAKVTQTELMRESFR 1884 + + E++ ++ Q ++ LEA E S++ E K+ E+ R R Sbjct: 2345 -----RLQEDKEQMAQQLAEETQG-FQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQAR 2398 Query: 1885 QKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDI 1944 +++A K EE+ E+LH A ++ + E Q Q+ Sbjct: 2399 AEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT--------------LEIQRQQSDHD 2444 Query: 1945 IDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKE 2004 +RL + + ELE E++++Q+E +LL + E M+ ++QLLQET+ L + Sbjct: 2445 AERLREAIA-------ELEREKEKLQQEAKLLQLKSEEMQTVQ---QEQLLQETQALQQS 2494 Query: 2005 KLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEK 2064 L +D L ++ E +E++ ++ +L Q++ + LR++ Q ++Q+E+ Sbjct: 2495 FL-------SEKDSLLQR----ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2543 Query: 2065 MRKFL---DEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEK 2121 R+ L E+A R+HE + + Q+ QQL E Q R+ E+L L E+ Sbjct: 2544 ERQRLVASMEEARRRQHEAEEGVRRKQEELQQL----------EQQRRQQEEL---LAEE 2590 Query: 2122 TDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVEDRKHFGAVEAKPELSLEV 2181 + E L E+ R +EE+ + V + D A EA+PE S + Sbjct: 2591 NQRLREQLQLLEEQHRAALAHSEEVTASQ--VAATKTLPNGRDALDGPAAEAEPEHSFD- 2647 Query: 2182 QLQAERDAIDRKEKEITNLEE 2202 L+ + A +E I + EE Sbjct: 2648 GLRRKVSAQRLQEAGILSAEE 2668 Score = 139 bits (349), Expect = 7e-32 Identities = 361/1895 (19%), Positives = 769/1895 (40%), Gaps = 224/1895 (11%) Query: 424 QETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITV 483 QE +LE L ++ Q V MK L Q + + ++ +RS+S T Sbjct: 866 QEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQL-----------IRSWSLATF 914 Query: 484 NEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQ 543 + + A++ L + Q + + G E++ +R+ S +Q Sbjct: 915 RTLKPEEQRQALHSLELHYQAFLRDSQ---DAGGFGPEDRLMAEREYGSC----SHHYQQ 967 Query: 544 IQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEML 603 + ++ + A++ES+ + +S ++D++ ++ A E+R T ++++L + Sbjct: 968 LLQSLEQGAQEESR---CQRCISELKDIRLQL-EACETR-----------TVHRLRLPLD 1012 Query: 604 EKEKNAVLDRMAESQ--EAELERLRTQL--LFSHEEELSKLKEDLEIEHRINIEKLKDNL 659 ++ R+AE Q +AE+E L + L + E++ L E + E L Sbjct: 1013 KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSEL---EL 1069 Query: 660 GIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQ--------SLVN 711 + +Q+ L +K++T+ + L +LK+ Q Sbjct: 1070 TLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATK 1129 Query: 712 SKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFA 771 + +++ Q Q + LR E + + + +Q+ + ++ ++ +E+ L E++ Sbjct: 1130 ASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQ 1189 Query: 772 QLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEIL-IEENE 830 + A+ + + E + L L+ + S + +L + + +++I+ + + +++ Sbjct: 1190 AVLAQTDVRQRELEQLGRQLRYYRE-SADPLGAWLQDARRR------QEQIQAMPLADSQ 1242 Query: 831 DLKQQCIQ---LNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQEL 887 +++Q Q L EEIE+ ++ + +++ L+ K LE + + Sbjct: 1243 AVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAK- 1301 Query: 888 EYKSKLKALNEELHLQRINPTTVKMK-SSVFDEDKTFVAETLEMGEVVEKDTTELMEKLE 946 K K+++ +E + + ++ T + +++ + F++ETL E E+ L E+ Sbjct: 1302 --KPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER----LAEQQR 1355 Query: 947 VTKREKLELSQRLSDLSEQLKQKHGEISFLNE-EVKSLKQEKEQVSLRCRELEIIINHNR 1005 +RE+L + + QL + H + E E K L+Q ++ +R RE + + Sbjct: 1356 AEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR-REEAAVDAQQQ 1414 Query: 1006 AENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEES 1065 ++Q Q+ + + +R AE + E S++ +E+++ + + Sbjct: 1415 KRSIQEELQQLRQSSEAEIQAKARQAEAA---------ERSRLRIEEEIRVVRLQLEATE 1465 Query: 1066 KQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYS 1125 +Q L +LRA +E + QK ++E+ ++Q E+QR + V Sbjct: 1466 RQRGGAEGEL------QALRAR--AEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVEL 1517 Query: 1126 THVDQVREYMENEKDKALCSLKEELIFAQEEKIK----ELQKIHQLELQTMKTQETGDEG 1181 + EK +AL +L+E + A+E + + E+++ Q+++ Q + + Sbjct: 1518 ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE-- 1575 Query: 1182 KPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPE 1241 +LQ + Q S+ E+ A E + + E+ E Sbjct: 1576 -------AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAE 1628 Query: 1242 LQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEE 1301 + R++++ + L + + L + K ++ + + E+ + + E Sbjct: 1629 RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRE 1688 Query: 1302 TEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNY 1361 + Q E + +L++ Q+L + + E + E + + L+++L ++ Sbjct: 1689 LAEQELEKQRQLAEG---TAQQRLAAEQELIRLRAETEQGEQQRQL--LEEELARLQREA 1743 Query: 1362 EAEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFG 1421 A QKR + +E + + V+ S A+ S +K+ +G F Sbjct: 1744 AA---ATQKRQELEAELA---KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFR 1797 Query: 1422 -VKEETNIVKLL--EKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAH 1478 + EE ++ L E + Q QL EE A + A A++ +++ E T +A Sbjct: 1798 ELAEEAARLRALAEEAKRQRQLAEEDA----ARQRAEAERVLAEKLAAIGEATRLKTEAE 1853 Query: 1479 AVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDI 1538 ++++ ++ + FQ + L ++ +H DI Sbjct: 1854 IALKEKEAENERLRRLAEDEAFQR------------RRLEEQAAQHKA----------DI 1891 Query: 1539 PESKDCVLTISEEMFSKDKTFI---VRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELV 1595 E + S+ + K + +RQ E + ++ AS + + ++ + Sbjct: 1892 EERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRI 1951 Query: 1596 RQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERV 1655 R A + LR ++E R+ Q +EE +R + + S+ E + + + Sbjct: 1952 RS-----NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA 2006 Query: 1656 LLEELEALKQLSLAGREKLCCELRNSSTQTQNGNEN-----QGEVEEQTF----KEKELD 1706 LEE+E LK R + S+ Q Q E Q E + F KE+EL Sbjct: 2007 ALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQ 2066 Query: 1707 R--KPEDVPPEILSNE----RYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRS 1760 + + E + L E R A ++A ++ E ++ VEE L +S Sbjct: 2067 QTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER------LKQS 2120 Query: 1761 SKSQSSASLIWRSEAEASVKSCVHEEHTRVTDE--SIPSYSGSDMPRNDINMWSKVT-EE 1817 ++ Q+ A ++ AE K E R E ++ +D +++ T + Sbjct: 2121 AEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ 2180 Query: 1818 GTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTE 1877 ++ Q L E D + + L+ RL+A + S+ +L +V E Sbjct: 2181 KAQVEQELTTLRLQLEETDHQ-KNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE 2239 Query: 1878 LMRESFR-QKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFER 1936 L + R + + L+ ++ + L EE+ +Q+A E ++ A + L E Sbjct: 2240 LSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE 2299 Query: 1937 QIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQ 1996 + ++ + +++ +E + A L+AE + +Q+++EL Q ++ + + QQL + Sbjct: 2300 DLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAE 2359 Query: 1997 ETEKLMK-------EKLEVQCQAEKVR--------------DDLQKQVKALEIDVEEQVS 2035 ET+ + +LE+ +AE+++ +D Q+ K E ++ E++ Sbjct: 2360 ETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE-EIGEKLH 2418 Query: 2036 RFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLK 2095 R QEK T + L Q Q + E++R+ + E E E++ QQE + L QLK Sbjct: 2419 RTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAEL----EREKEKLQQEAKLL--QLK 2472 Query: 2096 VVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKE----QLQRDIQERNEEIEKL-- 2149 E QT + EQL ++T + LS++ Q +R I++ ++E+L Sbjct: 2473 S-------EEMQTVQQEQLL----QETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQ 2521 Query: 2150 -----EFRVRELEQALLVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQL 2204 ++RE +Q + + + A E + Q +AE + + RK++E+ LE+Q Sbjct: 2522 DEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAE-EGVRRKQEELQQLEQQR 2580 Query: 2205 EQFREELENKNEEVQQLHMQLEIQKKESTTRLQEL 2239 Q E L +N+ +++ LE Q + + +E+ Sbjct: 2581 RQQEELLAEENQRLREQLQLLEEQHRAALAHSEEV 2615 Score = 125 bits (315), Expect = 6e-28 Identities = 335/1644 (20%), Positives = 647/1644 (39%), Gaps = 231/1644 (14%) Query: 2109 REVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEF-RVRELEQALLVEDRKH 2167 RE ++H ++ + + + QR I E + +LE R + + L D++ Sbjct: 956 REYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEP 1015 Query: 2168 FGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEI 2227 A E ++ + + QAE + + K + L + E+ L + L +LE+ Sbjct: 1016 --ARECAQRIAEQQKAQAEVEGLG---KGVARLSAEAEKVLA-LPEPSPAAPTLRSELEL 1069 Query: 2228 QKKESTTRLQELEQENKLFKDDMEKLGLAIKESD-AMSTQDQHVLFGKFAQIIQEKEVEI 2286 + +L+++ + ++ + ++ + L I+ + A H K AQ + E+ Sbjct: 1070 ----TLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPEL 1125 Query: 2287 DQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNE 2346 + + KL+ Q + + + +R + E L R+ E+E+ E Sbjct: 1126 EATKASLKKLRAQAE--AQQPTFDALRDELRGAQEVGERLQQRHG----ERDVEVERWRE 1179 Query: 2347 VIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKL-ALEQQVETANEEMTFMK 2405 + +L + + +T + L + L++ + A+ L A Q E++ M Sbjct: 1180 RVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRES--ADPLGAWLQDARRRQEQIQAMP 1237 Query: 2406 NVLKETNFKMNQLTQE---LFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLT 2462 L ++ QL QE L ++R E VE+ Q + +N D+ EL++V Sbjct: 1238 --LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY------ELQLVTY 1289 Query: 2463 EDALKSLENQTYFKSFEENGKGSII----NLETRLLQLESTVSAKDLELTQCYKQIKDMQ 2518 + L+ + + K ++G S+I +L T +L + S +++ +++++ + Sbjct: 1290 KAQLEPVASPAK-KPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEE 1348 Query: 2519 EQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNI 2578 + Q++ +++ E V AAL Q QL AK +E E + Sbjct: 1349 RLAE------QQRAEERERLAE--VEAALEKQRQLAEAHAQAK-------AQAEREAKEL 1393 Query: 2579 QNLNQ---LREDELGSDISALTLRISELESQVVEMHTSLILEK-EQVEIAEKNVLEKEKK 2634 Q Q +R +E D I E Q+ + + I K Q E AE++ L E++ Sbjct: 1394 QQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEE 1453 Query: 2635 LLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATK 2694 + ++ LE E+++ G EL+ALRA + + Sbjct: 1454 IRVVRLQLEATERQR---------------------------GGAEGELQALRARAEEAE 1486 Query: 2695 AELASYKEKAEKLQEELLVKETNMTSLQKDL-SQVRDHLAEAKEKLSILEKEDETEVQES 2753 A+ +E+AE+L+ ++ + + +L S+V+ A+EK L+ +E +Q Sbjct: 1487 AQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAE 1546 Query: 2754 KKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGI-QINLQSECSSEEVTEI 2812 + ++ ++ Q L+ + + ++ K A + Q E S +E Sbjct: 1547 EAERRLRQAEVERAR----QVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVA 1602 Query: 2813 ISQFTEKIEKMQELHA-AEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLR 2871 ++Q E+ E+ + A AE E+ E LK + ++L EE K++ Q Sbjct: 1603 VAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEA 1662 Query: 2872 SKEGSSIPE------LAHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESE 2925 K+ A A + RE+ + +EG ++ Sbjct: 1663 EKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ-------------LAEGTAQQRL 1709 Query: 2926 SATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSI-----QQVSEPWLEERKAYI 2980 +A + LRA +G Q L E + + + +Q E L + +A + Sbjct: 1710 AAEQELIR-----LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEM 1764 Query: 2981 NTISSLK--------DLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSV 3032 + + K K + + EAE + E + R A +Q L E Sbjct: 1765 EVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDA 1824 Query: 3033 LLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQK-----ADRRSLLSEIQ 3087 E A+G L+ + E +A E L++ A +R L E Sbjct: 1825 ARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA 1884 Query: 3088 ALH-AQMNGRKITLKREQESEKPSQE-LLEYNIQQKQSQMLEMQVELSSMKDRATELQEQ 3145 A H A + R L++ +SE Q+ L+E ++Q++ +++ E+ ++K Sbjct: 1885 AQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRR----QVEEEILALK--------- 1931 Query: 3146 LSSEKMVV--AELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLA 3203 S EK AEL+ EL + + E TL++ K ELEA R A Sbjct: 1932 ASFEKAAAGKAELELELGRIRSNAEDTLRS--KEQAELEAARQR------------QLAA 1977 Query: 3204 SEQKKSRELQWALEKEKA---KLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQ 3260 E+++ RE + ++K A + R + EE+E LK +E ++ + +Q Q Sbjct: 1978 EEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQ 2037 Query: 3261 LLNESQQK---IESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDREREL--- 3314 L E+ QK E + + Q E+ ELQ L+ E+ + ++ + R Sbjct: 2038 LAQEAAQKRLQAEEKAHAFAVQQKEQ-----ELQQTLQQEQSVLDQLRGEAEAARRAAEE 2092 Query: 3315 --HAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIV----ELLNETEKYKLDSLQT 3368 A++Q+ QSR + + LK+ ++ + ++ +L E E+ Q Sbjct: 2093 AEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQA 2152 Query: 3369 RQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRL 3428 Q + +Q ++ ++ + ++ +++ ++ L+ QLEE Q LD E QRL Sbjct: 2153 EQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRL 2212 Query: 3429 QGIMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYA 3488 + E +Q + EE+ S R+ + L++ L+ +IE E + Sbjct: 2213 KAEATEAARQRSQVEEELFSVRVQMEELSK---------------LKARIEAENR----- 2252 Query: 3489 KLIEMNGGGTGCNHELEMIRQKLQCVASKLQVLPQKASERLQFETADDEDFIWVQENIDE 3548 LI + T L+ +K++ VA + L A E + +ED + Q + E Sbjct: 2253 ALILRDKDNT--QRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED-LAQQRALAE 2309 Query: 3549 IILQLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKL 3608 +L+ E+ V +T + E LL+Q EL ++ +E D M +L Sbjct: 2310 KMLK---------EKMQAVQEATRLKAEAE-LLQQQKELAQEQARRLQE--DKEQMAQQL 2357 Query: 3609 EEQIRWYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRAE--AEVY 3666 E+ + +++T L + +++E E + ++ RAE A+ + Sbjct: 2358 AEETQGFQRT-----------LEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRF 2406 Query: 3667 KLKAELRNDSLLQTLSPDSEHVTL 3690 + +AE + L +T E VTL Sbjct: 2407 RKQAEEIGEKLHRTELATQEKVTL 2430 Score = 48.5 bits (114), Expect = 1e-04 Identities = 142/683 (20%), Positives = 274/683 (40%), Gaps = 64/683 (9%) Query: 3052 LLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNG---RKITLKREQESEK 3108 LL LEQ QE+ C + +SE++ + Q+ R + R ++ Sbjct: 968 LLQSLEQGAQEES-------RC------QRCISELKDIRLQLEACETRTVHRLRLPLDKE 1014 Query: 3109 PSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQT-KLEL 3167 P++E + +Q+++Q E+ + L + +EK++ S A T + EL Sbjct: 1015 PARECAQRIAEQQKAQ-----AEVEGLGKGVARLSAE--AEKVLALPEPSPAAPTLRSEL 1067 Query: 3168 ETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSE 3227 E TL + + ++ L A LE K KT + + A E ++ E Q + Sbjct: 1068 ELTL-GKLEQVRSLSAIYLE-KLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPEL 1125 Query: 3228 ERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRN 3287 E K L+ L+ E+Q+ L L +++ QQ+ +R + + E + Sbjct: 1126 EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQR-HGERDVEVERWRERVAQL 1184 Query: 3288 LEL-QVLLESEKVRIREMSST---LDRERE----LHAQLQSSDGTGQSRPPLPSEDLLKE 3339 LE Q +L VR RE+ L RE L A LQ + + +P D + Sbjct: 1185 LERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADS-QA 1243 Query: 3340 LQKQLEEKHSRIVELLNETEKYKLDSLQTRQQME--KDRQVHRKTLQTEQEANTEGQKKM 3397 +++QL ++ + + E+ EK + +Q + KD ++ T + + E KK Sbjct: 1244 VREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKP 1303 Query: 3398 HELQSKVEDLQRQLEEKRQQVYKLD-LEGQRLQGIMQEFQKQELEREEKRESRRILYQNL 3456 ++QS E + ++ + R +L L Q ++ I + ++ E E + R + L Sbjct: 1304 -KVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERL 1362 Query: 3457 NEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMI--RQKLQCV 3514 E +L R + + + + + AK ++ E + +Q+ + + Sbjct: 1363 AEVEA-ALEKQRQ---LAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSI 1418 Query: 3515 ASKLQVLPQKASERLQFET----ADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSPS 3570 +LQ L Q + +Q + A + + ++E I + LQL+ Q+G + Sbjct: 1419 QEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL 1478 Query: 3571 TSCGSLTERLLRQNAELTGHIS-QLTEEKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRFS 3629 + E RQ E + Q+ +E R ++L +++ + A R+ Sbjct: 1479 RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVK--AEAEAAREKQRALQ 1536 Query: 3630 LNGGANIEAIIA------SEKEVWNREKLTLQKSLKRAEAEVYKLKAELRNDSLLQTLSP 3683 ++A A +E E + ++ L+ + + AEAE+ +A + S Sbjct: 1537 ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1596 Query: 3684 DSEHVTLKRIYGKYLRAESFRKA 3706 EHV + + LR E+ R+A Sbjct: 1597 QEEHVAVAQ-----LREEAERRA 1614 Score = 35.8 bits (81), Expect = 0.85 Identities = 52/235 (22%), Positives = 101/235 (42%), Gaps = 31/235 (13%) Query: 2138 DIQE--RNEEIEKLEFRVRELEQALLVEDRKHFGAVEAK--PELSLEVQLQAERDAIDRK 2193 D+Q+ R E++ REL LL R H A E + P E+++ + + K Sbjct: 267 DVQDGVRANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQ-FLKFK 325 Query: 2194 EKEITNLEEQLEQFREELENKNEEVQQLHMQ-------LEIQKKESTTRLQELEQENKLF 2246 E E+ E + + ++ VQ ++ L+++K+ + LE+E +L Sbjct: 326 EMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQL- 384 Query: 2247 KDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDN 2306 + + E+L Q ++ ++ E + +QLN+ LQ +++ Sbjct: 385 RSEFERLECL-----------QRIV----TKLQMEAGLCEEQLNQADALLQSDVRLLAAG 429 Query: 2307 KVIEEKNELIRDL---ETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANI 2358 KV + E+ RDL ++ I L +D + +K R + EQ+ + +L + L I Sbjct: 430 KVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAI 484 Score = 35.8 bits (81), Expect = 0.85 Identities = 60/292 (20%), Positives = 111/292 (38%), Gaps = 39/292 (13%) Query: 4 EERQKKLEAGKAKLAQFR-------QRKAQSDGQ-----SPSKKQKKKRKTSSSKHDVSA 51 +E+ ++L+ K ++AQ QR +++ Q S ++ K R S+ A Sbjct: 2340 QEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA 2399 Query: 52 HHDLNIDQSQCNEMYINSSQRVESTVIPESTIMRTLH-SGEITSHEQGFSVELESEISTT 110 D + Q E+ R E + T+++TL + + H+ E +E+ Sbjct: 2400 EEDAQRFRKQAEEIG-EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELERE 2458 Query: 111 ADDCSSEVNGCSFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHE 170 + E K L EE V Q Q + L ++ Sbjct: 2459 KEKLQQEA----------KLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERF 2508 Query: 171 IEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLE 230 IE+ +LE++ + Q +E + +Q + +L A++++ARR + E Sbjct: 2509 IEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRR 2568 Query: 231 LTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDH 282 E+ Q+L+ Q +Q + +LL + Q L Q QL E+ H Sbjct: 2569 KQEELQQLEQQRRQQE---------------ELLAEENQRLREQLQLLEEQH 2605 >gi|41322914 plectin 1 isoform 10 [Homo sapiens] Length = 4551 Score = 192 bits (487), Expect = 7e-48 Identities = 274/1260 (21%), Positives = 544/1260 (43%), Gaps = 171/1260 (13%) Query: 1579 QLMLNEEQLEDMRQE---LVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNR 1635 +++ EE D +Q+ + + Q+ +Q++E QA RQ E + +++EEI+ + Sbjct: 1404 EVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRL 1463 Query: 1636 QLA----QRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNEN 1691 QL QR + E + R EE EA K+ + E+L ++++ S Q + Sbjct: 1464 QLEATERQRGGAEGE---LQALRARAEEAEAQKRQAQEEAERLRRQVQDES---QRKRQA 1517 Query: 1692 QGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGR 1751 + E+ + E E R+ + + L R ++A RL + +E + ET Sbjct: 1518 EVELASRVKAEAEAAREKQRAL-QALEELRLQAEEAERRLRQAEVERARQVQVALETA-- 1574 Query: 1752 HVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMW 1811 RS++++ + +E A ++ + EEH V Sbjct: 1575 ------QRSAEAELQSKRASFAEKTAQLERSLQEEHVAV--------------------- 1607 Query: 1812 SKVTEEGTELSQRLVRSGFAGTEIDPENE--ELMLNISSRLQAAVEKLLEAISETSSQLE 1869 +++ EE +Q+ + A E + E E +L N + RL+ E++ + S ++ E Sbjct: 1608 AQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE 1667 Query: 1870 HAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYAD 1929 K E RE+ R+ + ++++ +E + L ++ + E A + AE + Sbjct: 1668 KQK---EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRA 1724 Query: 1930 EKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELL------------- 1976 E E+Q Q + + RL++E A+ + QELEAE +++ E E+L Sbjct: 1725 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS 1784 Query: 1977 --SRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQV 2034 + K+ ++AEAG ++L +E +L E + Q + +D +Q E + E++ Sbjct: 1785 TSEKSKQRLEAEAGRF-RELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKL 1843 Query: 2035 SRFIE---LEQEKNTELMDLRQQNQALEKQLEK---MRKFLDEQAIDREHERDVFQQEIQ 2088 + E L+ E L + +N+ L + E R+ L+EQA +H+ D+ ++ Q Sbjct: 1844 AAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA--AQHKADIEERLAQ 1901 Query: 2089 KLEQQLKVVPRFQPISE---HQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEE 2145 + + R + + E Q R+VE+ LK +K + K +L+ ++ Sbjct: 1902 LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAA---AGKAELELELGRIRSN 1958 Query: 2146 IEKLEFRVRELEQALLVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLE 2205 E +R EQA L R+ A E + + R+A +R +K + EE Sbjct: 1959 AED---TLRSKEQAELEAARQRQLAAEEE---------RRRREAEERVQKSLAAEEEAAR 2006 Query: 2206 QFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMST 2265 Q + L EEV++L ++E ++ QE ++ +L ++ +K A +++ A + Sbjct: 2007 QRKAAL----EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAV 2062 Query: 2266 QDQHVLFGKFAQIIQEKEVEIDQLNEQV------------TKLQQQLKITTDNKVIEEKN 2313 Q + + Q +Q+++ +DQL + ++Q + + + +EE Sbjct: 2063 QQKE---QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAE 2119 Query: 2314 ELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEA 2373 L + E Q + Q ++ R+E + E + Q E A + QK + +A E Sbjct: 2120 RLKQSAEEQAQARAQAQAAAEKLRKEAEQ---EAARRAQAEQAALRQKQAADA-----EM 2171 Query: 2374 DSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVE 2433 + K + + +K +EQ E+T ++ L+ET+ + N L +EL LK E Sbjct: 2172 EKHKKFAEQTLRQKAQVEQ-------ELTTLRLQLEETDHQKNLLDEELQRLKAEATEAA 2224 Query: 2434 KIQSIPEN---SVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLE 2490 + +S E SV V ++ LSK K +E L+ +N F EE K + E Sbjct: 2225 RQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQ-EEAEKMKQVAEE 2283 Query: 2491 TRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQ 2550 L + + +A+ +L + +D+ +Q +ML++K+ +Q+ K A L+ Q Sbjct: 2284 AARLSVAAQEAARLRQLAE-----EDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQ 2338 Query: 2551 IQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQL------REDELGSDISALTLRISEL- 2603 Q E QE A+ Q+++ ++ Q + R+ E+ ++ L LR++E+ Sbjct: 2339 -QKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMS 2397 Query: 2604 -----------------ESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNE 2646 E ++H + + +E+V + + +++++ + ++L E Sbjct: 2398 RAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIA 2457 Query: 2647 KKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAEL-------AS 2699 + +REKEK + Q+ ++L+ +E + ++ E +AL+ ++ K L Sbjct: 2458 ELEREKEKLQ--QEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQ 2515 Query: 2700 YKEKAEKLQEELLVKETNMTS----LQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKK 2755 K K E+L ++ + K + Q+ + Q R L + E+ + E E V+ ++ Sbjct: 2516 EKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQE 2575 Score = 171 bits (433), Expect = 1e-41 Identities = 345/1688 (20%), Positives = 693/1688 (41%), Gaps = 223/1688 (13%) Query: 1837 PENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQ 1896 PE + S L+ + KL + S ++ LE K + R Q A E L+ Sbjct: 1058 PEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVI-----RGTQGAEEVLRAH 1112 Query: 1897 EELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCAS 1956 EE + +E AV + E + +K + + Q+ T D L EL A Sbjct: 1113 EE---------QLKEAQAVPATLPELEATKASLKKLRAQAEAQQPT--FDALRDELRGA- 1160 Query: 1957 NRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVR 2016 QE+ QQ ER++ + A+ Q +L +T+ +E ++ Q R Sbjct: 1161 ---QEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYR 1217 Query: 2017 DDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDE-QAID 2075 + L+ D + + + + + + +Q QAL +++E+ + ++E Q Sbjct: 1218 ESADPLGAWLQ-DARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFA 1276 Query: 2076 REHERDVFQQEIQKL--EQQLKVV------PRFQPISEHQTREVEQLANHLKEKTDKCSE 2127 +++ + E+Q + + QL+ V P+ Q SE +E L H E T S+ Sbjct: 1277 KQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQ 1336 Query: 2128 LL--LSKEQLQRDIQERNEEIEKLEFRVRELEQALLVEDRKHFGAVEAKPELSLEVQLQA 2185 + +S+ + + +ER E ++ E R R E +E ++ A + + QA Sbjct: 1337 YIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHA------QAKAQA 1390 Query: 2186 ERDAID---RKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQE 2242 ER+A + R ++E+ EE +++ + EE+QQL E + + + + E+ Sbjct: 1391 EREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERS 1450 Query: 2243 NKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKI 2302 ++++ + L ++ ++ + L A+ +E E + Q E+ +L++Q Sbjct: 1451 RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARA-EEAEAQKRQAQEEAERLRRQ--- 1506 Query: 2303 TTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKT 2362 ++++++ R E ++ + + R ++ ++ L E+ +LQ Sbjct: 1507 ------VQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL--RLQ---------- 1548 Query: 2363 SMNAHSLSEEADSLKHQLDVVIAEKL--ALEQQVETANEEMTFMKNVLKETNFKMNQLTQ 2420 +EEA+ Q +V A ++ ALE +A E+ + E ++ + Sbjct: 1549 -------AEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLER--- 1598 Query: 2421 ELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEE 2480 SL+ E +V +++ E + + + E E L LK+ E Sbjct: 1599 ---SLQEEHVAVAQLREEAERRAQQQAE-AERAREEAERELERWQLKANEA--------- 1645 Query: 2481 NGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQ----GQFETEMLQKKIVNLQ 2536 L RL Q E K L + KQ ++ + + G+ E + ++++ + Q Sbjct: 1646 --------LRLRL-QAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1696 Query: 2537 KIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGS---DI 2593 ++ +++ A +Q +L A QE + + +E E+ Q QL E+EL + Sbjct: 1697 ELEKQRQLAEGTAQQRLAAEQELIR-------LRAETEQGEQQR--QLLEEELARLQREA 1747 Query: 2594 SALTLRISELESQVVEMHTS---LILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQR 2650 +A T + ELE+++ ++ L+ K + E ++ EK K+ LE E ++ Sbjct: 1748 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA----EAGRFREL 1803 Query: 2651 EKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALR--AESVATKAELASYKEKAEKLQ 2708 +E R E K +L EE EA R AE +A E K +AE Sbjct: 1804 AEEAARLRALAEEAKRQRQLA---EEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIAL 1860 Query: 2709 EELLVKETNMTSLQKDLS--------QVRDHLAEAKEKLSILEKEDETEVQESK------ 2754 +E + + L +D + Q H A+ +E+L+ L K ++E++ K Sbjct: 1861 KEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDT 1920 Query: 2755 ----KACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVT 2810 + E L +K S A+ L++ I+ N + S+E Sbjct: 1921 LRQRRQVEEEILALKASFEKAAAGKAELELELGR-----------IRSNAEDTLRSKEQA 1969 Query: 2811 EIISQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCL 2870 E+ + ++ +E E + + ++ E R+ A+ EE LKA ++ Sbjct: 1970 ELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL----EEVERLKAKVEEA 2025 Query: 2871 R------SKEGSSIPELAHSDAY---QTREICSSDSGSDWGQGIYLTHSQGFDIASEGRG 2921 R +E + +LA A Q E + + Q + T Q + + RG Sbjct: 2026 RRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRG 2085 Query: 2922 EESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYIN 2981 E +E+A + A E +V + E+ S + +++ + E+ +A Sbjct: 2086 E-AEAARRA----------AEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQ 2134 Query: 2982 TISSLKDLITKMQLQ--REAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRT 3039 ++ + L + + + R A+ ++ + +D E + L +++ + T Sbjct: 2135 AQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTT 2194 Query: 3040 ELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADR-----RSLLSEIQALHAQMN 3094 L TD N L++ +Q E A + + R + E+ L A++ Sbjct: 2195 LRLQLEETDHQK--NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIE 2252 Query: 3095 G--RKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATEL---------Q 3143 R + L+ + +++ QE E K Q+ E LS A L Q Sbjct: 2253 AENRALILRDKDNTQRFLQEEAE-----KMKQVAEEAARLSVAAQEAARLRQLAEEDLAQ 2307 Query: 3144 EQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLA 3203 ++ +EKM+ ++++ T+L+ E L Q K L + +A RL+ + L +T Sbjct: 2308 QRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQG 2367 Query: 3204 S----EQKKSRELQWALEKEKAKL-----GRSEERDKEELEDLKFSLESQKQRNLQLNLL 3254 E ++ R+L+ + E E+ KL R++ R +E+ + + E ++ L L Sbjct: 2368 FQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEK-LHRTEL 2426 Query: 3255 LEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDREREL 3314 Q+K L ++ + I+ Q+ +DA+ E LE + ++ ++ ++ S + + Sbjct: 2427 ATQEKVTLVQTLE-IQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQ 2485 Query: 3315 HAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNE----TEKYKLDSLQTRQ 3370 LQ + QS L +D L + ++ +E++ +++ +L + ++ + + + +Q Sbjct: 2486 EQLLQETQALQQSF--LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQ 2543 Query: 3371 QMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQG 3430 QME++RQ + + + +EA + ++ K E+LQ+ +++RQQ L E QRL+ Sbjct: 2544 QMEQERQ---RLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLRE 2600 Query: 3431 IMQEFQKQ 3438 +Q ++Q Sbjct: 2601 QLQLLEEQ 2608 Score = 158 bits (399), Expect = 1e-37 Identities = 323/1676 (19%), Positives = 685/1676 (40%), Gaps = 242/1676 (14%) Query: 153 SPTHLEMMESELAGKQHEIEELNR-ELEEMR----VTYGTEGLQQ-LQEFEAAIKQRDGI 206 +PT +E L GK ++ L+ LE+++ V GT+G ++ L+ E +K+ + Sbjct: 1064 APTLRSELELTL-GKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAV 1122 Query: 207 ITQLT------ANLQQARREKDETMREFLELTEQ---SQKLQIQFQQLQASETLRNSTHS 257 L A+L++ R + + F L ++ +Q++ + QQ + Sbjct: 1123 PATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWR 1182 Query: 258 STAADLLQAKQQILTH----QQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQD 313 A LL+ Q +L Q++LE+ L Y++ + ++LQ+ + E Q Sbjct: 1183 ERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLG---AWLQDARRRQEQIQA 1239 Query: 314 KKVENSN--KEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQ 371 + +S +E++++++ ++EE+ +K E + + + + Q+V Sbjct: 1240 MPLADSQAVREQLRQEQALLEEIE----RHGEKVEECQRFAKQYINAIKDYELQLVTYKA 1295 Query: 372 EIKNMKLELTNSKQKERQSS--EEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRK 429 +++ + K + S +E L EL + +F ++ ++RME+E +R Sbjct: 1296 QLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEE-ERL 1354 Query: 430 LEQLRAE-----------------LDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEME 472 EQ RAE L E + Q Q ++E EE+ R + ++ Sbjct: 1355 AEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVD 1414 Query: 473 NALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKE---KLKEELGLI---LE----- 521 + S + E+ +L + E+ K + + + +++EE+ ++ LE Sbjct: 1415 AQQQKRS---IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQ 1471 Query: 522 ------EKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEI 575 E AL+ + E+ + ++E+ +R R+ + ++ + +A L++ +KAE Sbjct: 1472 RGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELAS--RVKAEA 1529 Query: 576 VSASESRKEL----ELKHEAEVTNYKIKLEMLEKEK--NAVLDRMAESQEAELERLRTQL 629 +A E ++ L EL+ +AE +++ +E+ + L+ S EAEL+ R Sbjct: 1530 EAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRA-- 1587 Query: 630 LFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDG--LQNEMSQKIETMQFEKDN 687 S E+ ++L+ L+ EH + + +L++ +QQ + + E +++E Q + + Sbjct: 1588 --SFAEKTAQLERSLQEEH-VAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANE 1644 Query: 688 LITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTL-EQEVQ 746 + + Q E+++ K L Q+ E +K+ E +E + +G EQ V+ Sbjct: 1645 ALRLRLQ-AEEVAQQKSLAQA--------------EAEKQKEEAEREARRRGKAEEQAVR 1689 Query: 747 ELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFL 806 + +L + LEKQ + E Q++ A AE +++ L+ T +++R + Sbjct: 1690 QRELAEQELEKQRQLAEGTAQQRLA---AEQELIR---------LRAETEQGEQQRQLLE 1737 Query: 807 DSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEI-----------EKQRNTFSFAEK 855 + + + ++E ++ ++L+ + ++ E+ E+ R+T +++ Sbjct: 1738 EEL------ARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQ 1791 Query: 856 NFEV---NYQELQEEYACLLKVKDD-------LEDSKNKQELEYK----SKLKALNEELH 901 E ++EL EE A L + ++ E+ +Q E + KL A+ E Sbjct: 1792 RLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATR 1851 Query: 902 LQRINPTTVKMKSSVFD------EDKTFVAETLEMGEVVEKDTTELMEKL-EVTKREKLE 954 L+ +K K + + ED+ F LE E + ++ E+L ++ K E Sbjct: 1852 LKTEAEIALKEKEAENERLRRLAEDEAFQRRRLE--EQAAQHKADIEERLAQLRKASDSE 1909 Query: 955 LSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDT 1014 L ++ + + L+Q+ + EE+ +LK E+ + ELE+ + R+ + + Sbjct: 1910 LERQKGLVEDTLRQRRQ----VEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS 1965 Query: 1015 QVSSLLDG-----VVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQ 1069 + + L+ + R + +V KS E + + K + E + + +E Sbjct: 1966 KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 2025 Query: 1070 LILDHLPSVTKESSLRATQPSENDKLQKE--LNVLKSEQNDLRLQMEAQRICLSLVYSTH 1127 L L+ Q + +LQ E + +Q + LQ Q+ + Sbjct: 2026 RRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ------EQSV 2079 Query: 1128 VDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLL 1187 +DQ+R E + +A +E + A+ E + +++ + E +E Sbjct: 2080 LDQLRGEAEAAR-RAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAA 2138 Query: 1188 IGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRY 1247 KL+K +E + Q + L + + E + + E Q R Sbjct: 2139 AEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE--------------QTLRQ 2184 Query: 1248 EVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSI 1307 + Q QE + TL ++ E ++ +L L ++ + T+ + + E E S+ Sbjct: 2185 KAQVEQE-LTTLRLQLEETDHQKNLLDEELQRLKAEATEAAR------QRSQVEEELFSV 2237 Query: 1308 HSQMTNLEDID--VNHKSKLSSLQDLEKTK--LEEQVQELESL------ISSLQQQLKET 1357 QM L + + +++ L+D + T+ L+E+ ++++ + +S Q+ Sbjct: 2238 RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARL 2297 Query: 1358 EQNYEAEI--------HCLQKRLQAVSEST---VPPSLPVDSVVITESDAQRTMYPGSCV 1406 Q E ++ L++++QAV E+T L + + A+R + Sbjct: 2298 RQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM 2357 Query: 1407 KKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISG 1466 + + +E + LE + Q QLE + + +A E+SR Sbjct: 2358 AQQL-----------AEETQGFQRTLEAERQRQLEMSAEAERLKLRVA-----EMSRAQA 2401 Query: 1467 GKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGK 1526 E A + A E+ + E+ + QT E + + + L + + E + Sbjct: 2402 RAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELER 2461 Query: 1527 EILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQ 1586 E + + + + T+ +E ++ T ++QS E S + R + + + Sbjct: 2462 EKEKLQQEAKLLQLKSEEMQTVQQEQLLQE-TQALQQSFLSE-KDSLLQRERFIEQEKAK 2519 Query: 1587 LEDM-------RQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQ 1639 LE + Q+L + Q QQ E RQ + ME R Q + +E ++R +L Q Sbjct: 2520 LEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQ 2579 Query: 1640 --RSSIDNENLVSERERVLLEELEALKQ---LSLAGREKLCCELRNSSTQTQNGNE 1690 + E L++E + L E+L+ L++ +LA E++ ++ NG + Sbjct: 2580 LEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRD 2635 Score = 151 bits (382), Expect = 1e-35 Identities = 318/1657 (19%), Positives = 679/1657 (40%), Gaps = 234/1657 (14%) Query: 1992 QQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDL 2051 QQLLQ E+ +E+ Q +++D ++ Q++A E ++ + L++E E Sbjct: 970 QQLLQSLEQGAQEESRCQRCISELKD-IRLQLEACETRTVHRLR--LPLDKEPARECAQR 1026 Query: 2052 RQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREV 2111 + Q + ++E + K + + + E ++ L + P + E ++ Sbjct: 1027 IAEQQKAQAEVEGLGKGVARLSAEAE--------KVLALPEPSPAAPTLRSELELTLGKL 1078 Query: 2112 EQLANHLKEKTDKCSELLL------SKEQLQRDIQERNEEIEKLEFRVRELEQALLVEDR 2165 EQ+ + +K + L E++ R +E+ +E + + + ELE + Sbjct: 1079 EQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKK 1138 Query: 2166 KHFGAVEAKPEL-SLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQ 2224 A +P +L +L+ ++ +R ++ + ++E++RE + E Q + Q Sbjct: 1139 LRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQ 1198 Query: 2225 LEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEV 2284 +++++E L++L ++ + +++ + LG ++++ Q Q + +Q ++E+ Sbjct: 1199 TDVRQRE----LEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLAD-SQAVREQLR 1253 Query: 2285 EIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRN-REEEIEQ 2343 + L E++ + + K+ + ++ I+D E Q+ + E V ++ +++ Sbjct: 1254 QEQALLEEIERHGE--KVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQS 1311 Query: 2344 LNE-VIEKLQQELANIGQKTSMNAHSLS---------EEADSLKHQLDVVIAEKLA---- 2389 +E VI++ + + T++ + + EE + L Q E+LA Sbjct: 1312 GSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEA 1371 Query: 2390 -LEQQVETANEEMTFMKNVLKETNFKMNQLTQELF--------SLKRERESVEKIQSIPE 2440 LE+Q + A +E ++ +E+ + +++R E++Q + + Sbjct: 1372 ALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQ 1431 Query: 2441 NS-VNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENG-KGSIINLETRLLQLES 2498 +S + + E + E+ ++ + Q + G +G + L R + E+ Sbjct: 1432 SSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEA 1491 Query: 2499 TVSAKDLELTQCYKQIKD-MQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQ 2557 E + +Q++D Q + Q E E+ + + E++ A + +++L+A + Sbjct: 1492 QKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQA-E 1550 Query: 2558 EYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILE 2617 E + + + + + ++ + E EL S ++ + ++LE + E H ++ Sbjct: 1551 EAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQL 1610 Query: 2618 KEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREK----------EKKRSPQDVEVLKTT 2667 +E+ E + E E+ E ++ LE + K E +++S E K Sbjct: 1611 REEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK 1670 Query: 2668 TELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQ 2727 E G E +A+R +A + EL ++ AE ++ L E + L+ + Q Sbjct: 1671 EEAEREARRRGKAEE-QAVRQRELAEQ-ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQ 1728 Query: 2728 VRDHLAEAKEKLSILEKEDETEVQ-----ESKKACMFEPLPIKLSKSIASQTDGTLKISS 2782 +E+L+ L++E Q E++ A + + + L+ ++ + S+ Sbjct: 1729 GEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR---ST 1785 Query: 2783 SNQTPQILVKNAGIQINLQSECSS----EEVTEIISQFTEKIEKMQELHAAEILDMESRH 2838 S ++ Q L AG L E + E + Q E+ Q A +L + Sbjct: 1786 SEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAA 1845 Query: 2839 ISETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREI------ 2892 I E LK E +A LKE + E + LA +A+Q R + Sbjct: 1846 IGEATRLKTEAEIA---LKE------------KEAENERLRRLAEDEAFQRRRLEEQAAQ 1890 Query: 2893 -------------CSSDSGSDWGQGIY--------------LTHSQGFDIASEGRGEES- 2924 +SDS + +G+ L F+ A+ G+ E Sbjct: 1891 HKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELEL 1950 Query: 2925 ------ESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVS--EPWLEER 2976 +A D+ K + L A Q+ + E + E+ + ++ E +R Sbjct: 1951 ELGRIRSNAEDTLRSKEQAELEAARQR--QLAAEEERRRREAEERVQKSLAAEEEAARQR 2008 Query: 2977 KAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLA--------------- 3021 KA + + LK + + + RE +S++ + + + L A Sbjct: 2009 KAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQE 2068 Query: 3022 LQQVFLEERSVL------------------LAAFRTELTALGTTDAVGLLNCLEQRIQEQ 3063 LQQ +E+SVL A + E A + V L+Q +EQ Sbjct: 2069 LQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQ 2128 Query: 3064 G---VEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQ 3120 + QAA E L+K + QA A + ++ ++ +K +++ L Q Sbjct: 2129 AQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQV 2188 Query: 3121 KQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKE 3180 +Q ++ ++++L + L E+L K E + +Q + EL +++ Q + L + Sbjct: 2189 EQ-ELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEEL-FSVRVQMEELSK 2246 Query: 3181 LEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEK---------EKAKLGRSEERDK 3231 L+A R+E +++ + ++T Q+++ +++ E+ E A+L + E D Sbjct: 2247 LKA-RIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDL 2305 Query: 3232 EELEDLKFSLESQKQRNLQLNL-------LLEQQKQLLNESQQKIESQRMLYDAQLSEE- 3283 + L + +K + +Q LL+QQK+L E ++++ + QL+EE Sbjct: 2306 AQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEET 2365 Query: 3284 QG----------RNLELQVLLESEKVRIREMSSTLDR-ERELHAQLQSSDGTGQS--RPP 3330 QG R LE+ E K+R+ EMS R E + + ++ G+ R Sbjct: 2366 QGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTE 2425 Query: 3331 LPSEDLLK-----ELQKQ-----LEEKHSRIVELLNETEKY---------KLDSLQTRQQ 3371 L +++ + E+Q+Q E I EL E EK K + +QT QQ Sbjct: 2426 LATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQ 2485 Query: 3372 ME--KDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDL--------QRQLEEKRQQVYKL 3421 + ++ Q +++ +E+++ + ++ + + ++K+E L Q+ EE+++Q ++ Sbjct: 2486 EQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQM 2545 Query: 3422 DLEGQRLQGIMQEFQKQELEREEKRESRRILYQNLNE 3458 + E QRL M+E ++++ E EE ++ Q L + Sbjct: 2546 EQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQ 2582 Score = 147 bits (370), Expect = 3e-34 Identities = 322/1585 (20%), Positives = 651/1585 (41%), Gaps = 255/1585 (16%) Query: 1858 LEAISETSSQLEHAKVTQTELMRESFRQKQEATESLK--------CQEELRERLHEESRA 1909 L+ Q++ + ++ +RE RQ+Q E ++ CQ ++ ++ Sbjct: 1227 LQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY 1286 Query: 1910 REQLAVELSK----------------AEGVIDGYADEKT-------LFERQIQEKTDIID 1946 QL ++ +E VI Y D +T L + I+ ++ + Sbjct: 1287 ELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLR 1346 Query: 1947 RLEQELLCASN-------RLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETE 1999 R+E+E A RL E+EA ++ ++ E ++ K + EA ++Q++ +E Sbjct: 1347 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1406 Query: 2000 KLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEK---NTELMDLRQQNQ 2056 + + ++ Q Q ++++LQ+ ++ E +++ + + E+ + E+ +R Q + Sbjct: 1407 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE 1466 Query: 2057 ALEKQ---LEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQ 2113 A E+Q E + L +A + E ++ Q+E ++L +Q+ Q S+ + + + Sbjct: 1467 ATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQV------QDESQRKRQAEVE 1520 Query: 2114 LANHLKEKTDKCSE---LLLSKEQLQRDIQERNEEIEKLEF-RVRELEQALLVEDRKHFG 2169 LA+ +K + + E L + E+L+ +E + + E R R+++ AL R Sbjct: 1521 LASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA 1580 Query: 2170 AVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLE---QFREELENKNEEVQQLHMQLE 2226 +++K E Q ER ++ + + L E+ E Q + E E EE ++ + + Sbjct: 1581 ELQSKRASFAEKTAQLER-SLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ 1639 Query: 2227 IQKKESTT-RLQ--ELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKE 2283 ++ E+ RLQ E+ Q+ L + + EK KE + + GK +E+ Sbjct: 1640 LKANEALRLRLQAEEVAQQKSLAQAEAEKQ----KEEAEREARRR----GK----AEEQA 1687 Query: 2284 VEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQ 2343 V +L EQ + Q+QL T + + + ELIR L ++ E E++ + Sbjct: 1688 VRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR--------LRAETE----QGEQQRQL 1735 Query: 2344 LNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTF 2403 L E + +LQ+E A QK L E ++ +++V++A K E++ + +E+ Sbjct: 1736 LEEELARLQREAAAATQKRQ----ELEAELAKVRAEMEVLLASKARAEEESRSTSEKS-- 1789 Query: 2404 MKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVN--------------VAIDH 2449 K L+ + +L +E L+ E ++ + + E AI Sbjct: 1790 -KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGE 1848 Query: 2450 LSKDKPELEVVLTE-----DALKSLENQTYF--KSFEENGKGSIINLETRLLQLESTVSA 2502 ++ K E E+ L E + L+ L F + EE ++E RL QL A Sbjct: 1849 ATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRK---A 1905 Query: 2503 KDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKF 2562 D EL + ++D Q + ++++I+ L+ E+ A +++L ++ A+ Sbjct: 1906 SDSELERQKGLVEDTLRQRR----QVEEEILALKASFEKAAAGKAELELELGRIRSNAE- 1960 Query: 2563 CQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVE 2622 T+ S+ + L R+ +L ++ R E E +V + SL E+E Sbjct: 1961 ----DTLRSKEQA----ELEAARQRQLAAEEER---RRREAEERVQK---SLAAEEEAAR 2006 Query: 2623 IAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNE 2682 K LE+ ++L K ++ RE+ ++ S + +++ + + Sbjct: 2007 -QRKAALEEVERL----KAKVEEARRLRERAEQESARQLQLAQEAAQ------------- 2048 Query: 2683 LEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSIL 2742 + L+AE KA + ++K ++LQ+ L +++ + L+ + R EA+E Sbjct: 2049 -KRLQAEE---KAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQA 2104 Query: 2743 EKE---DETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQIN 2799 E+E +V+E+++ + + + K + + + A ++ Sbjct: 2105 EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK 2164 Query: 2800 LQSECSSEEVTEIISQ-FTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLLKE 2858 ++ E+ + Q +K + QEL + + ET+ K LL E Sbjct: 2165 QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRL------QLEETDHQKN-------LLDE 2211 Query: 2859 ECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIASE 2918 E LKA +++ S + E S Q E+ + I +E Sbjct: 2212 ELQRLKAEAT-EAARQRSQVEEELFSVRVQMEELSKLKAR----------------IEAE 2254 Query: 2919 GRGE--ESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEER 2976 R + T F ++ ++ V E ++ + E ++Q++E L ++ Sbjct: 2255 NRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQ------EAARLRQLAEEDLAQQ 2308 Query: 2977 KAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAA 3036 +A K L KMQ +EA + LL Q+ +E++ L Sbjct: 2309 RALAE-----KMLKEKMQAVQEATRLKAEAE-----------LLQQQKELAQEQARRLQE 2352 Query: 3037 FRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGR 3096 + ++ + G LE Q Q +E A E L+ R + +S QA A+ + + Sbjct: 2353 DKEQMAQQLAEETQGFQRTLEAERQRQ-LEMSAEAERLKL--RVAEMSRAQA-RAEEDAQ 2408 Query: 3097 KITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAEL 3156 + + E+ EK + E Q+K + + ++++ A L+E +AEL Sbjct: 2409 RFRKQAEEIGEKLHRT--ELATQEKVTLVQTLEIQRQQSDHDAERLRE-------AIAEL 2459 Query: 3157 KSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWAL 3216 + E + KL+ E L LK E ++ + E L + SE+ + + + Sbjct: 2460 ERE--KEKLQQEAKLL----QLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFI 2513 Query: 3217 EKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLY 3276 E+EKAKL + + + + + L+ + Q+Q+ +EQ++Q L S + E++R + Sbjct: 2514 EQEKAKLEQLFQDEVAKAQQLREEQQRQQQQ-------MEQERQRLVASME--EARRRQH 2564 Query: 3277 DAQ----LSEEQGRNLELQ-----VLLESEKVRIREMSSTLDRERE---LHAQLQSSDGT 3324 +A+ +E+ + LE Q LL E R+RE L+ + H++ ++ Sbjct: 2565 EAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQV 2624 Query: 3325 GQSRPPLPSEDLLKELQKQLEEKHS 3349 ++ D L + E +HS Sbjct: 2625 AATKTLPNGRDALDGPAAEAEPEHS 2649 Score = 141 bits (356), Expect = 1e-32 Identities = 365/1881 (19%), Positives = 749/1881 (39%), Gaps = 298/1881 (15%) Query: 417 DIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALR 476 DI ++E R + +LR LD+ ++ Q + Q AQ E+E + Sbjct: 995 DIRLQLEACETRTVHRLRLPLDKEPARECAQ---RIAEQQKAQ---------AEVEGLGK 1042 Query: 477 SYSNITVNEDQIKLM---NVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQ---RQL 530 + ++ +++ + + A L +L+ T + E+++ + LE+ + R Sbjct: 1043 GVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGT 1102 Query: 531 EDLVEELSFSREQIQRARQ---TIAEQES------KLN-EAHKSLSTVEDLKAEIVSASE 580 + E L EQ++ A+ T+ E E+ KL +A T + L+ E+ A E Sbjct: 1103 QGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQE 1162 Query: 581 SRKELELKH---EAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEEL 637 + L+ +H + EV ++ ++ L + AVL + + ++ ELE+L QL + E Sbjct: 1163 VGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQ-TDVRQRELEQLGRQLRYYRESAD 1221 Query: 638 ---SKLKEDLEIEHRINIEKLKDNLGIHYK-QQIDGLQNEMS---QKIETMQ-FEKDNLI 689 + L++ + +I L D+ + + +Q L E+ +K+E Q F K + Sbjct: 1222 PLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYIN 1281 Query: 690 TKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQE----V 745 ++ + ++ L+ +K ++ + +E LR E TL + + Sbjct: 1282 AIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFI 1341 Query: 746 QELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIF 805 E + E E+ +++ + +E+ A++EA L+ +++ E + +E + Sbjct: 1342 SETLRRMEEEERLAEQQRAEERERLAEVEAA---LEKQRQLAEAHAQAKAQAEREAK--- 1395 Query: 806 LDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQ 865 ++ + ++ V +E E D +QQ + EE+++ R + +E + ++ + Sbjct: 1396 --ELQQRMQEEVVRRE-----EAAVDAQQQKRSIQEELQQLRQS---SEAEIQAKARQAE 1445 Query: 866 EEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVA 925 L++++++ + + E + + A E LQ + + + A Sbjct: 1446 AAERSRLRIEEEIRVVRLQLEATERQRGGAEGE---LQALRARAEEAE-----------A 1491 Query: 926 ETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQ 985 + + E E+ ++ ++ + ++ ++EL+ R+ +E ++K + L E L+ Sbjct: 1492 QKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE----LRL 1547 Query: 986 EKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEE 1045 + E+ R R+ E+ RA VQ + R AE + SF E+ Sbjct: 1548 QAEEAERRLRQAEV----ERARQVQVA-----------LETAQRSAEAELQSKRASFAEK 1592 Query: 1046 SKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSE 1105 + + E S QE+ + + + +E+ RA Q +E ++ ++E +E Sbjct: 1593 TAQL-------------ERSLQEEHVA--VAQLREEAERRAQQQAEAERAREE-----AE 1632 Query: 1106 QNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIH 1165 + R Q++A + + V Q + + E +K +EE +E ++ Sbjct: 1633 RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQ-----------KEEAEREARRRG 1681 Query: 1166 QLELQTMKTQETGDEG--KPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVN 1223 + E Q ++ +E ++ K L G Q+ ++ E L+ E Sbjct: 1682 KAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELI--------------RLRAETE 1727 Query: 1224 AEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQ 1283 +++ + E E LQ ++ + L KV E LL SK + Sbjct: 1728 QGEQQRQ---LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLA-----SKARAE 1779 Query: 1284 QTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQEL 1343 + E ++ L E F + + L + K + + L + Q E Sbjct: 1780 EESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ----RQLAEEDAARQRAEA 1835 Query: 1344 ESLISSLQQQLKE-TEQNYEAEIHCLQK-----RLQAVSESTVPPSLPVDSVVIT-ESDA 1396 E +++ + E T EAEI +K RL+ ++E ++ ++D Sbjct: 1836 ERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI 1895 Query: 1397 QRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFA 1456 + + + ++K D +E + G+ E+T + + Q+EEE+ + S A A Sbjct: 1896 EERL---AQLRKASDSELE--RQKGLVEDT-------LRQRRQVEEEILALKASFEKAAA 1943 Query: 1457 QQTELS----RISGGKENTASSK---------QAHAVCQQEQHY------------FNEM 1491 + EL RI E+T SK Q ++E+ E Sbjct: 1944 GKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 2003 Query: 1492 KLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDI--PESKDCVLTIS 1549 Q + + E + K +E + + E +++ L+ E K + Sbjct: 2004 AARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQ 2063 Query: 1550 EEMFSKDKTFIVRQSIHDEISVSSMDASR--------QLMLNEEQLEDMRQ----ELVRQ 1597 ++ +T QS+ D++ + A R ++ E + RQ E ++Q Sbjct: 2064 QKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQ 2123 Query: 1598 YQEHQQATELLRQAHMRQMERQREDQ--EQLQEEIKRLNRQLAQRSSIDNENLVSE---R 1652 E Q QA ++ ++ E + + Q E L ++ A + ++ +E R Sbjct: 2124 SAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLR 2183 Query: 1653 ERVLLE-ELEALK-QLSLAGREK--LCCELRNSSTQTQNGNENQGEVEEQTFKEKELDRK 1708 ++ +E EL L+ QL +K L EL+ + + +VEE+ F + + Sbjct: 2184 QKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE 2243 Query: 1709 PEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSAS 1768 + I + R + + + + L E + V E R S +Q +A Sbjct: 2244 LSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAAR-------LSVAAQEAAR 2296 Query: 1769 LIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRS 1828 L +E + + + + E+ + +++ + + +++ ++ EL+Q R Sbjct: 2297 LRQLAEEDLAQQRALAEKMLKEKMQAVQEATR-------LKAEAELLQQQKELAQEQAR- 2348 Query: 1829 GFAGTEIDPENEELMLNISSRLQAAVEKLLEAIS----ETSSQLEHAKVTQTELMRESFR 1884 + + E++ ++ Q ++ LEA E S++ E K+ E+ R R Sbjct: 2349 -----RLQEDKEQMAQQLAEETQG-FQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQAR 2402 Query: 1885 QKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDI 1944 +++A K EE+ E+LH A ++ + E Q Q+ Sbjct: 2403 AEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT--------------LEIQRQQSDHD 2448 Query: 1945 IDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKE 2004 +RL + + ELE E++++Q+E +LL + E M+ ++QLLQET+ L + Sbjct: 2449 AERLREAIA-------ELEREKEKLQQEAKLLQLKSEEMQTVQ---QEQLLQETQALQQS 2498 Query: 2005 KLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEK 2064 L +D L ++ E +E++ ++ +L Q++ + LR++ Q ++Q+E+ Sbjct: 2499 FL-------SEKDSLLQR----ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2547 Query: 2065 MRKFL---DEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEK 2121 R+ L E+A R+HE + + Q+ QQL E Q R+ E+L L E+ Sbjct: 2548 ERQRLVASMEEARRRQHEAEEGVRRKQEELQQL----------EQQRRQQEEL---LAEE 2594 Query: 2122 TDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVEDRKHFGAVEAKPELSLEV 2181 + E L E+ R +EE+ + V + D A EA+PE S + Sbjct: 2595 NQRLREQLQLLEEQHRAALAHSEEVTASQ--VAATKTLPNGRDALDGPAAEAEPEHSFD- 2651 Query: 2182 QLQAERDAIDRKEKEITNLEE 2202 L+ + A +E I + EE Sbjct: 2652 GLRRKVSAQRLQEAGILSAEE 2672 Score = 139 bits (349), Expect = 7e-32 Identities = 361/1895 (19%), Positives = 769/1895 (40%), Gaps = 224/1895 (11%) Query: 424 QETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITV 483 QE +LE L ++ Q V MK L Q + + ++ +RS+S T Sbjct: 870 QEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQL-----------IRSWSLATF 918 Query: 484 NEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQ 543 + + A++ L + Q + + G E++ +R+ S +Q Sbjct: 919 RTLKPEEQRQALHSLELHYQAFLRDSQ---DAGGFGPEDRLMAEREYGSC----SHHYQQ 971 Query: 544 IQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEML 603 + ++ + A++ES+ + +S ++D++ ++ A E+R T ++++L + Sbjct: 972 LLQSLEQGAQEESR---CQRCISELKDIRLQL-EACETR-----------TVHRLRLPLD 1016 Query: 604 EKEKNAVLDRMAESQ--EAELERLRTQL--LFSHEEELSKLKEDLEIEHRINIEKLKDNL 659 ++ R+AE Q +AE+E L + L + E++ L E + E L Sbjct: 1017 KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSEL---EL 1073 Query: 660 GIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQ--------SLVN 711 + +Q+ L +K++T+ + L +LK+ Q Sbjct: 1074 TLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATK 1133 Query: 712 SKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFA 771 + +++ Q Q + LR E + + + +Q+ + ++ ++ +E+ L E++ Sbjct: 1134 ASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQ 1193 Query: 772 QLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEIL-IEENE 830 + A+ + + E + L L+ + S + +L + + +++I+ + + +++ Sbjct: 1194 AVLAQTDVRQRELEQLGRQLRYYRE-SADPLGAWLQDARRR------QEQIQAMPLADSQ 1246 Query: 831 DLKQQCIQ---LNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQEL 887 +++Q Q L EEIE+ ++ + +++ L+ K LE + + Sbjct: 1247 AVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAK- 1305 Query: 888 EYKSKLKALNEELHLQRINPTTVKMK-SSVFDEDKTFVAETLEMGEVVEKDTTELMEKLE 946 K K+++ +E + + ++ T + +++ + F++ETL E E+ L E+ Sbjct: 1306 --KPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER----LAEQQR 1359 Query: 947 VTKREKLELSQRLSDLSEQLKQKHGEISFLNE-EVKSLKQEKEQVSLRCRELEIIINHNR 1005 +RE+L + + QL + H + E E K L+Q ++ +R RE + + Sbjct: 1360 AEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR-REEAAVDAQQQ 1418 Query: 1006 AENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEES 1065 ++Q Q+ + + +R AE + E S++ +E+++ + + Sbjct: 1419 KRSIQEELQQLRQSSEAEIQAKARQAEAA---------ERSRLRIEEEIRVVRLQLEATE 1469 Query: 1066 KQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYS 1125 +Q L +LRA +E + QK ++E+ ++Q E+QR + V Sbjct: 1470 RQRGGAEGEL------QALRAR--AEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVEL 1521 Query: 1126 THVDQVREYMENEKDKALCSLKEELIFAQEEKIK----ELQKIHQLELQTMKTQETGDEG 1181 + EK +AL +L+E + A+E + + E+++ Q+++ Q + + Sbjct: 1522 ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE-- 1579 Query: 1182 KPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPE 1241 +LQ + Q S+ E+ A E + + E+ E Sbjct: 1580 -------AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAE 1632 Query: 1242 LQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEE 1301 + R++++ + L + + L + K ++ + + E+ + + E Sbjct: 1633 RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRE 1692 Query: 1302 TEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNY 1361 + Q E + +L++ Q+L + + E + E + + L+++L ++ Sbjct: 1693 LAEQELEKQRQLAEG---TAQQRLAAEQELIRLRAETEQGEQQRQL--LEEELARLQREA 1747 Query: 1362 EAEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFG 1421 A QKR + +E + + V+ S A+ S +K+ +G F Sbjct: 1748 AA---ATQKRQELEAELA---KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFR 1801 Query: 1422 -VKEETNIVKLL--EKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAH 1478 + EE ++ L E + Q QL EE A + A A++ +++ E T +A Sbjct: 1802 ELAEEAARLRALAEEAKRQRQLAEEDA----ARQRAEAERVLAEKLAAIGEATRLKTEAE 1857 Query: 1479 AVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDI 1538 ++++ ++ + FQ + L ++ +H DI Sbjct: 1858 IALKEKEAENERLRRLAEDEAFQR------------RRLEEQAAQHKA----------DI 1895 Query: 1539 PESKDCVLTISEEMFSKDKTFI---VRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELV 1595 E + S+ + K + +RQ E + ++ AS + + ++ + Sbjct: 1896 EERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRI 1955 Query: 1596 RQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERV 1655 R A + LR ++E R+ Q +EE +R + + S+ E + + + Sbjct: 1956 RS-----NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA 2010 Query: 1656 LLEELEALKQLSLAGREKLCCELRNSSTQTQNGNEN-----QGEVEEQTF----KEKELD 1706 LEE+E LK R + S+ Q Q E Q E + F KE+EL Sbjct: 2011 ALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQ 2070 Query: 1707 R--KPEDVPPEILSNE----RYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRS 1760 + + E + L E R A ++A ++ E ++ VEE L +S Sbjct: 2071 QTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER------LKQS 2124 Query: 1761 SKSQSSASLIWRSEAEASVKSCVHEEHTRVTDE--SIPSYSGSDMPRNDINMWSKVT-EE 1817 ++ Q+ A ++ AE K E R E ++ +D +++ T + Sbjct: 2125 AEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ 2184 Query: 1818 GTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTE 1877 ++ Q L E D + + L+ RL+A + S+ +L +V E Sbjct: 2185 KAQVEQELTTLRLQLEETDHQ-KNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE 2243 Query: 1878 LMRESFR-QKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFER 1936 L + R + + L+ ++ + L EE+ +Q+A E ++ A + L E Sbjct: 2244 LSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE 2303 Query: 1937 QIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQ 1996 + ++ + +++ +E + A L+AE + +Q+++EL Q ++ + + QQL + Sbjct: 2304 DLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAE 2363 Query: 1997 ETEKLMK-------EKLEVQCQAEKVR--------------DDLQKQVKALEIDVEEQVS 2035 ET+ + +LE+ +AE+++ +D Q+ K E ++ E++ Sbjct: 2364 ETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE-EIGEKLH 2422 Query: 2036 RFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLK 2095 R QEK T + L Q Q + E++R+ + E E E++ QQE + L QLK Sbjct: 2423 RTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAEL----EREKEKLQQEAKLL--QLK 2476 Query: 2096 VVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKE----QLQRDIQERNEEIEKL-- 2149 E QT + EQL ++T + LS++ Q +R I++ ++E+L Sbjct: 2477 S-------EEMQTVQQEQLL----QETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQ 2525 Query: 2150 -----EFRVRELEQALLVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQL 2204 ++RE +Q + + + A E + Q +AE + + RK++E+ LE+Q Sbjct: 2526 DEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAE-EGVRRKQEELQQLEQQR 2584 Query: 2205 EQFREELENKNEEVQQLHMQLEIQKKESTTRLQEL 2239 Q E L +N+ +++ LE Q + + +E+ Sbjct: 2585 RQQEELLAEENQRLREQLQLLEEQHRAALAHSEEV 2619 Score = 125 bits (315), Expect = 6e-28 Identities = 335/1644 (20%), Positives = 647/1644 (39%), Gaps = 231/1644 (14%) Query: 2109 REVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEF-RVRELEQALLVEDRKH 2167 RE ++H ++ + + + QR I E + +LE R + + L D++ Sbjct: 960 REYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEP 1019 Query: 2168 FGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEI 2227 A E ++ + + QAE + + K + L + E+ L + L +LE+ Sbjct: 1020 --ARECAQRIAEQQKAQAEVEGLG---KGVARLSAEAEKVLA-LPEPSPAAPTLRSELEL 1073 Query: 2228 QKKESTTRLQELEQENKLFKDDMEKLGLAIKESD-AMSTQDQHVLFGKFAQIIQEKEVEI 2286 + +L+++ + ++ + ++ + L I+ + A H K AQ + E+ Sbjct: 1074 ----TLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPEL 1129 Query: 2287 DQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNE 2346 + + KL+ Q + + + +R + E L R+ E+E+ E Sbjct: 1130 EATKASLKKLRAQAE--AQQPTFDALRDELRGAQEVGERLQQRHG----ERDVEVERWRE 1183 Query: 2347 VIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKL-ALEQQVETANEEMTFMK 2405 + +L + + +T + L + L++ + A+ L A Q E++ M Sbjct: 1184 RVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRES--ADPLGAWLQDARRRQEQIQAMP 1241 Query: 2406 NVLKETNFKMNQLTQE---LFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLT 2462 L ++ QL QE L ++R E VE+ Q + +N D+ EL++V Sbjct: 1242 --LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY------ELQLVTY 1293 Query: 2463 EDALKSLENQTYFKSFEENGKGSII----NLETRLLQLESTVSAKDLELTQCYKQIKDMQ 2518 + L+ + + K ++G S+I +L T +L + S +++ +++++ + Sbjct: 1294 KAQLEPVASPAK-KPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEE 1352 Query: 2519 EQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNI 2578 + Q++ +++ E V AAL Q QL AK +E E + Sbjct: 1353 RLAE------QQRAEERERLAE--VEAALEKQRQLAEAHAQAK-------AQAEREAKEL 1397 Query: 2579 QNLNQ---LREDELGSDISALTLRISELESQVVEMHTSLILEK-EQVEIAEKNVLEKEKK 2634 Q Q +R +E D I E Q+ + + I K Q E AE++ L E++ Sbjct: 1398 QQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEE 1457 Query: 2635 LLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATK 2694 + ++ LE E+++ G EL+ALRA + + Sbjct: 1458 IRVVRLQLEATERQR---------------------------GGAEGELQALRARAEEAE 1490 Query: 2695 AELASYKEKAEKLQEELLVKETNMTSLQKDL-SQVRDHLAEAKEKLSILEKEDETEVQES 2753 A+ +E+AE+L+ ++ + + +L S+V+ A+EK L+ +E +Q Sbjct: 1491 AQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAE 1550 Query: 2754 KKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGI-QINLQSECSSEEVTEI 2812 + ++ ++ Q L+ + + ++ K A + Q E S +E Sbjct: 1551 EAERRLRQAEVERAR----QVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVA 1606 Query: 2813 ISQFTEKIEKMQELHA-AEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLR 2871 ++Q E+ E+ + A AE E+ E LK + ++L EE K++ Q Sbjct: 1607 VAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEA 1666 Query: 2872 SKEGSSIPE------LAHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESE 2925 K+ A A + RE+ + +EG ++ Sbjct: 1667 EKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ-------------LAEGTAQQRL 1713 Query: 2926 SATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSI-----QQVSEPWLEERKAYI 2980 +A + LRA +G Q L E + + + +Q E L + +A + Sbjct: 1714 AAEQELIR-----LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEM 1768 Query: 2981 NTISSLK--------DLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSV 3032 + + K K + + EAE + E + R A +Q L E Sbjct: 1769 EVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDA 1828 Query: 3033 LLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQK-----ADRRSLLSEIQ 3087 E A+G L+ + E +A E L++ A +R L E Sbjct: 1829 ARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA 1888 Query: 3088 ALH-AQMNGRKITLKREQESEKPSQE-LLEYNIQQKQSQMLEMQVELSSMKDRATELQEQ 3145 A H A + R L++ +SE Q+ L+E ++Q++ +++ E+ ++K Sbjct: 1889 AQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRR----QVEEEILALK--------- 1935 Query: 3146 LSSEKMVV--AELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLA 3203 S EK AEL+ EL + + E TL++ K ELEA R A Sbjct: 1936 ASFEKAAAGKAELELELGRIRSNAEDTLRS--KEQAELEAARQR------------QLAA 1981 Query: 3204 SEQKKSRELQWALEKEKA---KLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQ 3260 E+++ RE + ++K A + R + EE+E LK +E ++ + +Q Q Sbjct: 1982 EEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQ 2041 Query: 3261 LLNESQQK---IESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDREREL--- 3314 L E+ QK E + + Q E+ ELQ L+ E+ + ++ + R Sbjct: 2042 LAQEAAQKRLQAEEKAHAFAVQQKEQ-----ELQQTLQQEQSVLDQLRGEAEAARRAAEE 2096 Query: 3315 --HAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIV----ELLNETEKYKLDSLQT 3368 A++Q+ QSR + + LK+ ++ + ++ +L E E+ Q Sbjct: 2097 AEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQA 2156 Query: 3369 RQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRL 3428 Q + +Q ++ ++ + ++ +++ ++ L+ QLEE Q LD E QRL Sbjct: 2157 EQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRL 2216 Query: 3429 QGIMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYA 3488 + E +Q + EE+ S R+ + L++ L+ +IE E + Sbjct: 2217 KAEATEAARQRSQVEEELFSVRVQMEELSK---------------LKARIEAENR----- 2256 Query: 3489 KLIEMNGGGTGCNHELEMIRQKLQCVASKLQVLPQKASERLQFETADDEDFIWVQENIDE 3548 LI + T L+ +K++ VA + L A E + +ED + Q + E Sbjct: 2257 ALILRDKDNT--QRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED-LAQQRALAE 2313 Query: 3549 IILQLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKL 3608 +L+ E+ V +T + E LL+Q EL ++ +E D M +L Sbjct: 2314 KMLK---------EKMQAVQEATRLKAEAE-LLQQQKELAQEQARRLQE--DKEQMAQQL 2361 Query: 3609 EEQIRWYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRAE--AEVY 3666 E+ + +++T L + +++E E + ++ RAE A+ + Sbjct: 2362 AEETQGFQRT-----------LEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRF 2410 Query: 3667 KLKAELRNDSLLQTLSPDSEHVTL 3690 + +AE + L +T E VTL Sbjct: 2411 RKQAEEIGEKLHRTELATQEKVTL 2434 Score = 48.5 bits (114), Expect = 1e-04 Identities = 142/683 (20%), Positives = 274/683 (40%), Gaps = 64/683 (9%) Query: 3052 LLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNG---RKITLKREQESEK 3108 LL LEQ QE+ C + +SE++ + Q+ R + R ++ Sbjct: 972 LLQSLEQGAQEES-------RC------QRCISELKDIRLQLEACETRTVHRLRLPLDKE 1018 Query: 3109 PSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQT-KLEL 3167 P++E + +Q+++Q E+ + L + +EK++ S A T + EL Sbjct: 1019 PARECAQRIAEQQKAQ-----AEVEGLGKGVARLSAE--AEKVLALPEPSPAAPTLRSEL 1071 Query: 3168 ETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSE 3227 E TL + + ++ L A LE K KT + + A E ++ E Q + Sbjct: 1072 ELTL-GKLEQVRSLSAIYLE-KLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPEL 1129 Query: 3228 ERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRN 3287 E K L+ L+ E+Q+ L L +++ QQ+ +R + + E + Sbjct: 1130 EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQR-HGERDVEVERWRERVAQL 1188 Query: 3288 LEL-QVLLESEKVRIREMSST---LDRERE----LHAQLQSSDGTGQSRPPLPSEDLLKE 3339 LE Q +L VR RE+ L RE L A LQ + + +P D + Sbjct: 1189 LERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADS-QA 1247 Query: 3340 LQKQLEEKHSRIVELLNETEKYKLDSLQTRQQME--KDRQVHRKTLQTEQEANTEGQKKM 3397 +++QL ++ + + E+ EK + +Q + KD ++ T + + E KK Sbjct: 1248 VREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKP 1307 Query: 3398 HELQSKVEDLQRQLEEKRQQVYKLD-LEGQRLQGIMQEFQKQELEREEKRESRRILYQNL 3456 ++QS E + ++ + R +L L Q ++ I + ++ E E + R + L Sbjct: 1308 -KVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERL 1366 Query: 3457 NEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMI--RQKLQCV 3514 E +L R + + + + + AK ++ E + +Q+ + + Sbjct: 1367 AEVEA-ALEKQRQ---LAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSI 1422 Query: 3515 ASKLQVLPQKASERLQFET----ADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSPS 3570 +LQ L Q + +Q + A + + ++E I + LQL+ Q+G + Sbjct: 1423 QEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL 1482 Query: 3571 TSCGSLTERLLRQNAELTGHIS-QLTEEKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRFS 3629 + E RQ E + Q+ +E R ++L +++ + A R+ Sbjct: 1483 RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVK--AEAEAAREKQRALQ 1540 Query: 3630 LNGGANIEAIIA------SEKEVWNREKLTLQKSLKRAEAEVYKLKAELRNDSLLQTLSP 3683 ++A A +E E + ++ L+ + + AEAE+ +A + S Sbjct: 1541 ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1600 Query: 3684 DSEHVTLKRIYGKYLRAESFRKA 3706 EHV + + LR E+ R+A Sbjct: 1601 QEEHVAVAQ-----LREEAERRA 1618 Score = 35.8 bits (81), Expect = 0.85 Identities = 52/235 (22%), Positives = 101/235 (42%), Gaps = 31/235 (13%) Query: 2138 DIQE--RNEEIEKLEFRVRELEQALLVEDRKHFGAVEAK--PELSLEVQLQAERDAIDRK 2193 D+Q+ R E++ REL LL R H A E + P E+++ + + K Sbjct: 271 DVQDGVRANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQ-FLKFK 329 Query: 2194 EKEITNLEEQLEQFREELENKNEEVQQLHMQ-------LEIQKKESTTRLQELEQENKLF 2246 E E+ E + + ++ VQ ++ L+++K+ + LE+E +L Sbjct: 330 EMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQL- 388 Query: 2247 KDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDN 2306 + + E+L Q ++ ++ E + +QLN+ LQ +++ Sbjct: 389 RSEFERLECL-----------QRIV----TKLQMEAGLCEEQLNQADALLQSDVRLLAAG 433 Query: 2307 KVIEEKNELIRDL---ETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANI 2358 KV + E+ RDL ++ I L +D + +K R + EQ+ + +L + L I Sbjct: 434 KVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAI 488 Score = 35.8 bits (81), Expect = 0.85 Identities = 60/292 (20%), Positives = 111/292 (38%), Gaps = 39/292 (13%) Query: 4 EERQKKLEAGKAKLAQFR-------QRKAQSDGQ-----SPSKKQKKKRKTSSSKHDVSA 51 +E+ ++L+ K ++AQ QR +++ Q S ++ K R S+ A Sbjct: 2344 QEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA 2403 Query: 52 HHDLNIDQSQCNEMYINSSQRVESTVIPESTIMRTLH-SGEITSHEQGFSVELESEISTT 110 D + Q E+ R E + T+++TL + + H+ E +E+ Sbjct: 2404 EEDAQRFRKQAEEIG-EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELERE 2462 Query: 111 ADDCSSEVNGCSFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHE 170 + E K L EE V Q Q + L ++ Sbjct: 2463 KEKLQQEA----------KLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERF 2512 Query: 171 IEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLE 230 IE+ +LE++ + Q +E + +Q + +L A++++ARR + E Sbjct: 2513 IEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRR 2572 Query: 231 LTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDH 282 E+ Q+L+ Q +Q + +LL + Q L Q QL E+ H Sbjct: 2573 KQEELQQLEQQRRQQE---------------ELLAEENQRLREQLQLLEEQH 2609 >gi|41322919 plectin 1 isoform 8 [Homo sapiens] Length = 4547 Score = 192 bits (487), Expect = 7e-48 Identities = 274/1260 (21%), Positives = 544/1260 (43%), Gaps = 171/1260 (13%) Query: 1579 QLMLNEEQLEDMRQE---LVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNR 1635 +++ EE D +Q+ + + Q+ +Q++E QA RQ E + +++EEI+ + Sbjct: 1400 EVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRL 1459 Query: 1636 QLA----QRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNEN 1691 QL QR + E + R EE EA K+ + E+L ++++ S Q + Sbjct: 1460 QLEATERQRGGAEGE---LQALRARAEEAEAQKRQAQEEAERLRRQVQDES---QRKRQA 1513 Query: 1692 QGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGR 1751 + E+ + E E R+ + + L R ++A RL + +E + ET Sbjct: 1514 EVELASRVKAEAEAAREKQRAL-QALEELRLQAEEAERRLRQAEVERARQVQVALETA-- 1570 Query: 1752 HVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMW 1811 RS++++ + +E A ++ + EEH V Sbjct: 1571 ------QRSAEAELQSKRASFAEKTAQLERSLQEEHVAV--------------------- 1603 Query: 1812 SKVTEEGTELSQRLVRSGFAGTEIDPENE--ELMLNISSRLQAAVEKLLEAISETSSQLE 1869 +++ EE +Q+ + A E + E E +L N + RL+ E++ + S ++ E Sbjct: 1604 AQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE 1663 Query: 1870 HAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYAD 1929 K E RE+ R+ + ++++ +E + L ++ + E A + AE + Sbjct: 1664 KQK---EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRA 1720 Query: 1930 EKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELL------------- 1976 E E+Q Q + + RL++E A+ + QELEAE +++ E E+L Sbjct: 1721 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS 1780 Query: 1977 --SRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQV 2034 + K+ ++AEAG ++L +E +L E + Q + +D +Q E + E++ Sbjct: 1781 TSEKSKQRLEAEAGRF-RELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKL 1839 Query: 2035 SRFIE---LEQEKNTELMDLRQQNQALEKQLEK---MRKFLDEQAIDREHERDVFQQEIQ 2088 + E L+ E L + +N+ L + E R+ L+EQA +H+ D+ ++ Q Sbjct: 1840 AAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA--AQHKADIEERLAQ 1897 Query: 2089 KLEQQLKVVPRFQPISE---HQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEE 2145 + + R + + E Q R+VE+ LK +K + K +L+ ++ Sbjct: 1898 LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAA---AGKAELELELGRIRSN 1954 Query: 2146 IEKLEFRVRELEQALLVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLE 2205 E +R EQA L R+ A E + + R+A +R +K + EE Sbjct: 1955 AED---TLRSKEQAELEAARQRQLAAEEE---------RRRREAEERVQKSLAAEEEAAR 2002 Query: 2206 QFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMST 2265 Q + L EEV++L ++E ++ QE ++ +L ++ +K A +++ A + Sbjct: 2003 QRKAAL----EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAV 2058 Query: 2266 QDQHVLFGKFAQIIQEKEVEIDQLNEQV------------TKLQQQLKITTDNKVIEEKN 2313 Q + + Q +Q+++ +DQL + ++Q + + + +EE Sbjct: 2059 QQKE---QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAE 2115 Query: 2314 ELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEA 2373 L + E Q + Q ++ R+E + E + Q E A + QK + +A E Sbjct: 2116 RLKQSAEEQAQARAQAQAAAEKLRKEAEQ---EAARRAQAEQAALRQKQAADA-----EM 2167 Query: 2374 DSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVE 2433 + K + + +K +EQ E+T ++ L+ET+ + N L +EL LK E Sbjct: 2168 EKHKKFAEQTLRQKAQVEQ-------ELTTLRLQLEETDHQKNLLDEELQRLKAEATEAA 2220 Query: 2434 KIQSIPEN---SVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLE 2490 + +S E SV V ++ LSK K +E L+ +N F EE K + E Sbjct: 2221 RQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQ-EEAEKMKQVAEE 2279 Query: 2491 TRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQ 2550 L + + +A+ +L + +D+ +Q +ML++K+ +Q+ K A L+ Q Sbjct: 2280 AARLSVAAQEAARLRQLAE-----EDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQ 2334 Query: 2551 IQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQL------REDELGSDISALTLRISEL- 2603 Q E QE A+ Q+++ ++ Q + R+ E+ ++ L LR++E+ Sbjct: 2335 -QKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMS 2393 Query: 2604 -----------------ESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNE 2646 E ++H + + +E+V + + +++++ + ++L E Sbjct: 2394 RAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIA 2453 Query: 2647 KKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAEL-------AS 2699 + +REKEK + Q+ ++L+ +E + ++ E +AL+ ++ K L Sbjct: 2454 ELEREKEKLQ--QEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQ 2511 Query: 2700 YKEKAEKLQEELLVKETNMTS----LQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKK 2755 K K E+L ++ + K + Q+ + Q R L + E+ + E E V+ ++ Sbjct: 2512 EKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQE 2571 Score = 171 bits (433), Expect = 1e-41 Identities = 345/1688 (20%), Positives = 693/1688 (41%), Gaps = 223/1688 (13%) Query: 1837 PENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQ 1896 PE + S L+ + KL + S ++ LE K + R Q A E L+ Sbjct: 1054 PEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVI-----RGTQGAEEVLRAH 1108 Query: 1897 EELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCAS 1956 EE + +E AV + E + +K + + Q+ T D L EL A Sbjct: 1109 EE---------QLKEAQAVPATLPELEATKASLKKLRAQAEAQQPT--FDALRDELRGA- 1156 Query: 1957 NRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVR 2016 QE+ QQ ER++ + A+ Q +L +T+ +E ++ Q R Sbjct: 1157 ---QEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYR 1213 Query: 2017 DDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDE-QAID 2075 + L+ D + + + + + + +Q QAL +++E+ + ++E Q Sbjct: 1214 ESADPLGAWLQ-DARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFA 1272 Query: 2076 REHERDVFQQEIQKL--EQQLKVV------PRFQPISEHQTREVEQLANHLKEKTDKCSE 2127 +++ + E+Q + + QL+ V P+ Q SE +E L H E T S+ Sbjct: 1273 KQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQ 1332 Query: 2128 LL--LSKEQLQRDIQERNEEIEKLEFRVRELEQALLVEDRKHFGAVEAKPELSLEVQLQA 2185 + +S+ + + +ER E ++ E R R E +E ++ A + + QA Sbjct: 1333 YIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHA------QAKAQA 1386 Query: 2186 ERDAID---RKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQE 2242 ER+A + R ++E+ EE +++ + EE+QQL E + + + + E+ Sbjct: 1387 EREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERS 1446 Query: 2243 NKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKI 2302 ++++ + L ++ ++ + L A+ +E E + Q E+ +L++Q Sbjct: 1447 RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARA-EEAEAQKRQAQEEAERLRRQ--- 1502 Query: 2303 TTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKT 2362 ++++++ R E ++ + + R ++ ++ L E+ +LQ Sbjct: 1503 ------VQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL--RLQ---------- 1544 Query: 2363 SMNAHSLSEEADSLKHQLDVVIAEKL--ALEQQVETANEEMTFMKNVLKETNFKMNQLTQ 2420 +EEA+ Q +V A ++ ALE +A E+ + E ++ + Sbjct: 1545 -------AEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLER--- 1594 Query: 2421 ELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEE 2480 SL+ E +V +++ E + + + E E L LK+ E Sbjct: 1595 ---SLQEEHVAVAQLREEAERRAQQQAE-AERAREEAERELERWQLKANEA--------- 1641 Query: 2481 NGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQ----GQFETEMLQKKIVNLQ 2536 L RL Q E K L + KQ ++ + + G+ E + ++++ + Q Sbjct: 1642 --------LRLRL-QAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1692 Query: 2537 KIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGS---DI 2593 ++ +++ A +Q +L A QE + + +E E+ Q QL E+EL + Sbjct: 1693 ELEKQRQLAEGTAQQRLAAEQELIR-------LRAETEQGEQQR--QLLEEELARLQREA 1743 Query: 2594 SALTLRISELESQVVEMHTS---LILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQR 2650 +A T + ELE+++ ++ L+ K + E ++ EK K+ LE E ++ Sbjct: 1744 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA----EAGRFREL 1799 Query: 2651 EKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALR--AESVATKAELASYKEKAEKLQ 2708 +E R E K +L EE EA R AE +A E K +AE Sbjct: 1800 AEEAARLRALAEEAKRQRQLA---EEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIAL 1856 Query: 2709 EELLVKETNMTSLQKDLS--------QVRDHLAEAKEKLSILEKEDETEVQESK------ 2754 +E + + L +D + Q H A+ +E+L+ L K ++E++ K Sbjct: 1857 KEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDT 1916 Query: 2755 ----KACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVT 2810 + E L +K S A+ L++ I+ N + S+E Sbjct: 1917 LRQRRQVEEEILALKASFEKAAAGKAELELELGR-----------IRSNAEDTLRSKEQA 1965 Query: 2811 EIISQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCL 2870 E+ + ++ +E E + + ++ E R+ A+ EE LKA ++ Sbjct: 1966 ELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL----EEVERLKAKVEEA 2021 Query: 2871 R------SKEGSSIPELAHSDAY---QTREICSSDSGSDWGQGIYLTHSQGFDIASEGRG 2921 R +E + +LA A Q E + + Q + T Q + + RG Sbjct: 2022 RRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRG 2081 Query: 2922 EESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYIN 2981 E +E+A + A E +V + E+ S + +++ + E+ +A Sbjct: 2082 E-AEAARRA----------AEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQ 2130 Query: 2982 TISSLKDLITKMQLQ--REAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRT 3039 ++ + L + + + R A+ ++ + +D E + L +++ + T Sbjct: 2131 AQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTT 2190 Query: 3040 ELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADR-----RSLLSEIQALHAQMN 3094 L TD N L++ +Q E A + + R + E+ L A++ Sbjct: 2191 LRLQLEETDHQK--NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIE 2248 Query: 3095 G--RKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATEL---------Q 3143 R + L+ + +++ QE E K Q+ E LS A L Q Sbjct: 2249 AENRALILRDKDNTQRFLQEEAE-----KMKQVAEEAARLSVAAQEAARLRQLAEEDLAQ 2303 Query: 3144 EQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLA 3203 ++ +EKM+ ++++ T+L+ E L Q K L + +A RL+ + L +T Sbjct: 2304 QRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQG 2363 Query: 3204 S----EQKKSRELQWALEKEKAKL-----GRSEERDKEELEDLKFSLESQKQRNLQLNLL 3254 E ++ R+L+ + E E+ KL R++ R +E+ + + E ++ L L Sbjct: 2364 FQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEK-LHRTEL 2422 Query: 3255 LEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDREREL 3314 Q+K L ++ + I+ Q+ +DA+ E LE + ++ ++ ++ S + + Sbjct: 2423 ATQEKVTLVQTLE-IQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQ 2481 Query: 3315 HAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNE----TEKYKLDSLQTRQ 3370 LQ + QS L +D L + ++ +E++ +++ +L + ++ + + + +Q Sbjct: 2482 EQLLQETQALQQSF--LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQ 2539 Query: 3371 QMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQG 3430 QME++RQ + + + +EA + ++ K E+LQ+ +++RQQ L E QRL+ Sbjct: 2540 QMEQERQ---RLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLRE 2596 Query: 3431 IMQEFQKQ 3438 +Q ++Q Sbjct: 2597 QLQLLEEQ 2604 Score = 158 bits (399), Expect = 1e-37 Identities = 323/1676 (19%), Positives = 685/1676 (40%), Gaps = 242/1676 (14%) Query: 153 SPTHLEMMESELAGKQHEIEELNR-ELEEMR----VTYGTEGLQQ-LQEFEAAIKQRDGI 206 +PT +E L GK ++ L+ LE+++ V GT+G ++ L+ E +K+ + Sbjct: 1060 APTLRSELELTL-GKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAV 1118 Query: 207 ITQLT------ANLQQARREKDETMREFLELTEQ---SQKLQIQFQQLQASETLRNSTHS 257 L A+L++ R + + F L ++ +Q++ + QQ + Sbjct: 1119 PATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWR 1178 Query: 258 STAADLLQAKQQILTH----QQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQD 313 A LL+ Q +L Q++LE+ L Y++ + ++LQ+ + E Q Sbjct: 1179 ERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLG---AWLQDARRRQEQIQA 1235 Query: 314 KKVENSN--KEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQ 371 + +S +E++++++ ++EE+ +K E + + + + Q+V Sbjct: 1236 MPLADSQAVREQLRQEQALLEEIE----RHGEKVEECQRFAKQYINAIKDYELQLVTYKA 1291 Query: 372 EIKNMKLELTNSKQKERQSS--EEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRK 429 +++ + K + S +E L EL + +F ++ ++RME+E +R Sbjct: 1292 QLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEE-ERL 1350 Query: 430 LEQLRAE-----------------LDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEME 472 EQ RAE L E + Q Q ++E EE+ R + ++ Sbjct: 1351 AEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVD 1410 Query: 473 NALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKE---KLKEELGLI---LE----- 521 + S + E+ +L + E+ K + + + +++EE+ ++ LE Sbjct: 1411 AQQQKRS---IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQ 1467 Query: 522 ------EKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEI 575 E AL+ + E+ + ++E+ +R R+ + ++ + +A L++ +KAE Sbjct: 1468 RGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELAS--RVKAEA 1525 Query: 576 VSASESRKEL----ELKHEAEVTNYKIKLEMLEKEK--NAVLDRMAESQEAELERLRTQL 629 +A E ++ L EL+ +AE +++ +E+ + L+ S EAEL+ R Sbjct: 1526 EAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRA-- 1583 Query: 630 LFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDG--LQNEMSQKIETMQFEKDN 687 S E+ ++L+ L+ EH + + +L++ +QQ + + E +++E Q + + Sbjct: 1584 --SFAEKTAQLERSLQEEH-VAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANE 1640 Query: 688 LITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTL-EQEVQ 746 + + Q E+++ K L Q+ E +K+ E +E + +G EQ V+ Sbjct: 1641 ALRLRLQ-AEEVAQQKSLAQA--------------EAEKQKEEAEREARRRGKAEEQAVR 1685 Query: 747 ELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFL 806 + +L + LEKQ + E Q++ A AE +++ L+ T +++R + Sbjct: 1686 QRELAEQELEKQRQLAEGTAQQRLA---AEQELIR---------LRAETEQGEQQRQLLE 1733 Query: 807 DSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEI-----------EKQRNTFSFAEK 855 + + + ++E ++ ++L+ + ++ E+ E+ R+T +++ Sbjct: 1734 EEL------ARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQ 1787 Query: 856 NFEV---NYQELQEEYACLLKVKDD-------LEDSKNKQELEYK----SKLKALNEELH 901 E ++EL EE A L + ++ E+ +Q E + KL A+ E Sbjct: 1788 RLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATR 1847 Query: 902 LQRINPTTVKMKSSVFD------EDKTFVAETLEMGEVVEKDTTELMEKL-EVTKREKLE 954 L+ +K K + + ED+ F LE E + ++ E+L ++ K E Sbjct: 1848 LKTEAEIALKEKEAENERLRRLAEDEAFQRRRLE--EQAAQHKADIEERLAQLRKASDSE 1905 Query: 955 LSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDT 1014 L ++ + + L+Q+ + EE+ +LK E+ + ELE+ + R+ + + Sbjct: 1906 LERQKGLVEDTLRQRRQ----VEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS 1961 Query: 1015 QVSSLLDG-----VVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQ 1069 + + L+ + R + +V KS E + + K + E + + +E Sbjct: 1962 KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 2021 Query: 1070 LILDHLPSVTKESSLRATQPSENDKLQKE--LNVLKSEQNDLRLQMEAQRICLSLVYSTH 1127 L L+ Q + +LQ E + +Q + LQ Q+ + Sbjct: 2022 RRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ------EQSV 2075 Query: 1128 VDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLL 1187 +DQ+R E + +A +E + A+ E + +++ + E +E Sbjct: 2076 LDQLRGEAEAAR-RAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAA 2134 Query: 1188 IGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRY 1247 KL+K +E + Q + L + + E + + E Q R Sbjct: 2135 AEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE--------------QTLRQ 2180 Query: 1248 EVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSI 1307 + Q QE + TL ++ E ++ +L L ++ + T+ + + E E S+ Sbjct: 2181 KAQVEQE-LTTLRLQLEETDHQKNLLDEELQRLKAEATEAAR------QRSQVEEELFSV 2233 Query: 1308 HSQMTNLEDID--VNHKSKLSSLQDLEKTK--LEEQVQELESL------ISSLQQQLKET 1357 QM L + + +++ L+D + T+ L+E+ ++++ + +S Q+ Sbjct: 2234 RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARL 2293 Query: 1358 EQNYEAEI--------HCLQKRLQAVSEST---VPPSLPVDSVVITESDAQRTMYPGSCV 1406 Q E ++ L++++QAV E+T L + + A+R + Sbjct: 2294 RQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM 2353 Query: 1407 KKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISG 1466 + + +E + LE + Q QLE + + +A E+SR Sbjct: 2354 AQQL-----------AEETQGFQRTLEAERQRQLEMSAEAERLKLRVA-----EMSRAQA 2397 Query: 1467 GKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGK 1526 E A + A E+ + E+ + QT E + + + L + + E + Sbjct: 2398 RAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELER 2457 Query: 1527 EILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQ 1586 E + + + + T+ +E ++ T ++QS E S + R + + + Sbjct: 2458 EKEKLQQEAKLLQLKSEEMQTVQQEQLLQE-TQALQQSFLSE-KDSLLQRERFIEQEKAK 2515 Query: 1587 LEDM-------RQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQ 1639 LE + Q+L + Q QQ E RQ + ME R Q + +E ++R +L Q Sbjct: 2516 LEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQ 2575 Query: 1640 --RSSIDNENLVSERERVLLEELEALKQ---LSLAGREKLCCELRNSSTQTQNGNE 1690 + E L++E + L E+L+ L++ +LA E++ ++ NG + Sbjct: 2576 LEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRD 2631 Score = 151 bits (382), Expect = 1e-35 Identities = 318/1657 (19%), Positives = 679/1657 (40%), Gaps = 234/1657 (14%) Query: 1992 QQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDL 2051 QQLLQ E+ +E+ Q +++D ++ Q++A E ++ + L++E E Sbjct: 966 QQLLQSLEQGAQEESRCQRCISELKD-IRLQLEACETRTVHRLR--LPLDKEPARECAQR 1022 Query: 2052 RQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREV 2111 + Q + ++E + K + + + E ++ L + P + E ++ Sbjct: 1023 IAEQQKAQAEVEGLGKGVARLSAEAE--------KVLALPEPSPAAPTLRSELELTLGKL 1074 Query: 2112 EQLANHLKEKTDKCSELLL------SKEQLQRDIQERNEEIEKLEFRVRELEQALLVEDR 2165 EQ+ + +K + L E++ R +E+ +E + + + ELE + Sbjct: 1075 EQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKK 1134 Query: 2166 KHFGAVEAKPEL-SLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQ 2224 A +P +L +L+ ++ +R ++ + ++E++RE + E Q + Q Sbjct: 1135 LRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQ 1194 Query: 2225 LEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEV 2284 +++++E L++L ++ + +++ + LG ++++ Q Q + +Q ++E+ Sbjct: 1195 TDVRQRE----LEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLAD-SQAVREQLR 1249 Query: 2285 EIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRN-REEEIEQ 2343 + L E++ + + K+ + ++ I+D E Q+ + E V ++ +++ Sbjct: 1250 QEQALLEEIERHGE--KVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQS 1307 Query: 2344 LNE-VIEKLQQELANIGQKTSMNAHSLS---------EEADSLKHQLDVVIAEKLA---- 2389 +E VI++ + + T++ + + EE + L Q E+LA Sbjct: 1308 GSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEA 1367 Query: 2390 -LEQQVETANEEMTFMKNVLKETNFKMNQLTQELF--------SLKRERESVEKIQSIPE 2440 LE+Q + A +E ++ +E+ + +++R E++Q + + Sbjct: 1368 ALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQ 1427 Query: 2441 NS-VNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENG-KGSIINLETRLLQLES 2498 +S + + E + E+ ++ + Q + G +G + L R + E+ Sbjct: 1428 SSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEA 1487 Query: 2499 TVSAKDLELTQCYKQIKD-MQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQ 2557 E + +Q++D Q + Q E E+ + + E++ A + +++L+A + Sbjct: 1488 QKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQA-E 1546 Query: 2558 EYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILE 2617 E + + + + + ++ + E EL S ++ + ++LE + E H ++ Sbjct: 1547 EAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQL 1606 Query: 2618 KEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREK----------EKKRSPQDVEVLKTT 2667 +E+ E + E E+ E ++ LE + K E +++S E K Sbjct: 1607 REEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK 1666 Query: 2668 TELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQ 2727 E G E +A+R +A + EL ++ AE ++ L E + L+ + Q Sbjct: 1667 EEAEREARRRGKAEE-QAVRQRELAEQ-ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQ 1724 Query: 2728 VRDHLAEAKEKLSILEKEDETEVQ-----ESKKACMFEPLPIKLSKSIASQTDGTLKISS 2782 +E+L+ L++E Q E++ A + + + L+ ++ + S+ Sbjct: 1725 GEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR---ST 1781 Query: 2783 SNQTPQILVKNAGIQINLQSECSS----EEVTEIISQFTEKIEKMQELHAAEILDMESRH 2838 S ++ Q L AG L E + E + Q E+ Q A +L + Sbjct: 1782 SEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAA 1841 Query: 2839 ISETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREI------ 2892 I E LK E +A LKE + E + LA +A+Q R + Sbjct: 1842 IGEATRLKTEAEIA---LKE------------KEAENERLRRLAEDEAFQRRRLEEQAAQ 1886 Query: 2893 -------------CSSDSGSDWGQGIY--------------LTHSQGFDIASEGRGEES- 2924 +SDS + +G+ L F+ A+ G+ E Sbjct: 1887 HKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELEL 1946 Query: 2925 ------ESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVS--EPWLEER 2976 +A D+ K + L A Q+ + E + E+ + ++ E +R Sbjct: 1947 ELGRIRSNAEDTLRSKEQAELEAARQR--QLAAEEERRRREAEERVQKSLAAEEEAARQR 2004 Query: 2977 KAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLA--------------- 3021 KA + + LK + + + RE +S++ + + + L A Sbjct: 2005 KAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQE 2064 Query: 3022 LQQVFLEERSVL------------------LAAFRTELTALGTTDAVGLLNCLEQRIQEQ 3063 LQQ +E+SVL A + E A + V L+Q +EQ Sbjct: 2065 LQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQ 2124 Query: 3064 G---VEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQ 3120 + QAA E L+K + QA A + ++ ++ +K +++ L Q Sbjct: 2125 AQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQV 2184 Query: 3121 KQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKE 3180 +Q ++ ++++L + L E+L K E + +Q + EL +++ Q + L + Sbjct: 2185 EQ-ELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEEL-FSVRVQMEELSK 2242 Query: 3181 LEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEK---------EKAKLGRSEERDK 3231 L+A R+E +++ + ++T Q+++ +++ E+ E A+L + E D Sbjct: 2243 LKA-RIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDL 2301 Query: 3232 EELEDLKFSLESQKQRNLQLNL-------LLEQQKQLLNESQQKIESQRMLYDAQLSEE- 3283 + L + +K + +Q LL+QQK+L E ++++ + QL+EE Sbjct: 2302 AQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEET 2361 Query: 3284 QG----------RNLELQVLLESEKVRIREMSSTLDR-ERELHAQLQSSDGTGQS--RPP 3330 QG R LE+ E K+R+ EMS R E + + ++ G+ R Sbjct: 2362 QGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTE 2421 Query: 3331 LPSEDLLK-----ELQKQ-----LEEKHSRIVELLNETEKY---------KLDSLQTRQQ 3371 L +++ + E+Q+Q E I EL E EK K + +QT QQ Sbjct: 2422 LATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQ 2481 Query: 3372 ME--KDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDL--------QRQLEEKRQQVYKL 3421 + ++ Q +++ +E+++ + ++ + + ++K+E L Q+ EE+++Q ++ Sbjct: 2482 EQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQM 2541 Query: 3422 DLEGQRLQGIMQEFQKQELEREEKRESRRILYQNLNE 3458 + E QRL M+E ++++ E EE ++ Q L + Sbjct: 2542 EQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQ 2578 Score = 147 bits (370), Expect = 3e-34 Identities = 322/1585 (20%), Positives = 651/1585 (41%), Gaps = 255/1585 (16%) Query: 1858 LEAISETSSQLEHAKVTQTELMRESFRQKQEATESLK--------CQEELRERLHEESRA 1909 L+ Q++ + ++ +RE RQ+Q E ++ CQ ++ ++ Sbjct: 1223 LQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY 1282 Query: 1910 REQLAVELSK----------------AEGVIDGYADEKT-------LFERQIQEKTDIID 1946 QL ++ +E VI Y D +T L + I+ ++ + Sbjct: 1283 ELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLR 1342 Query: 1947 RLEQELLCASN-------RLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETE 1999 R+E+E A RL E+EA ++ ++ E ++ K + EA ++Q++ +E Sbjct: 1343 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1402 Query: 2000 KLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEK---NTELMDLRQQNQ 2056 + + ++ Q Q ++++LQ+ ++ E +++ + + E+ + E+ +R Q + Sbjct: 1403 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE 1462 Query: 2057 ALEKQ---LEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQ 2113 A E+Q E + L +A + E ++ Q+E ++L +Q+ Q S+ + + + Sbjct: 1463 ATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQV------QDESQRKRQAEVE 1516 Query: 2114 LANHLKEKTDKCSE---LLLSKEQLQRDIQERNEEIEKLEF-RVRELEQALLVEDRKHFG 2169 LA+ +K + + E L + E+L+ +E + + E R R+++ AL R Sbjct: 1517 LASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA 1576 Query: 2170 AVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLE---QFREELENKNEEVQQLHMQLE 2226 +++K E Q ER ++ + + L E+ E Q + E E EE ++ + + Sbjct: 1577 ELQSKRASFAEKTAQLER-SLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ 1635 Query: 2227 IQKKESTT-RLQ--ELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKE 2283 ++ E+ RLQ E+ Q+ L + + EK KE + + GK +E+ Sbjct: 1636 LKANEALRLRLQAEEVAQQKSLAQAEAEKQ----KEEAEREARRR----GK----AEEQA 1683 Query: 2284 VEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQ 2343 V +L EQ + Q+QL T + + + ELIR L ++ E E++ + Sbjct: 1684 VRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR--------LRAETE----QGEQQRQL 1731 Query: 2344 LNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTF 2403 L E + +LQ+E A QK L E ++ +++V++A K E++ + +E+ Sbjct: 1732 LEEELARLQREAAAATQKRQ----ELEAELAKVRAEMEVLLASKARAEEESRSTSEKS-- 1785 Query: 2404 MKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVN--------------VAIDH 2449 K L+ + +L +E L+ E ++ + + E AI Sbjct: 1786 -KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGE 1844 Query: 2450 LSKDKPELEVVLTE-----DALKSLENQTYF--KSFEENGKGSIINLETRLLQLESTVSA 2502 ++ K E E+ L E + L+ L F + EE ++E RL QL A Sbjct: 1845 ATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRK---A 1901 Query: 2503 KDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKF 2562 D EL + ++D Q + ++++I+ L+ E+ A +++L ++ A+ Sbjct: 1902 SDSELERQKGLVEDTLRQRR----QVEEEILALKASFEKAAAGKAELELELGRIRSNAE- 1956 Query: 2563 CQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVE 2622 T+ S+ + L R+ +L ++ R E E +V + SL E+E Sbjct: 1957 ----DTLRSKEQA----ELEAARQRQLAAEEER---RRREAEERVQK---SLAAEEEAAR 2002 Query: 2623 IAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNE 2682 K LE+ ++L K ++ RE+ ++ S + +++ + + Sbjct: 2003 -QRKAALEEVERL----KAKVEEARRLRERAEQESARQLQLAQEAAQ------------- 2044 Query: 2683 LEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSIL 2742 + L+AE KA + ++K ++LQ+ L +++ + L+ + R EA+E Sbjct: 2045 -KRLQAEE---KAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQA 2100 Query: 2743 EKE---DETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQIN 2799 E+E +V+E+++ + + + K + + + A ++ Sbjct: 2101 EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK 2160 Query: 2800 LQSECSSEEVTEIISQ-FTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLLKE 2858 ++ E+ + Q +K + QEL + + ET+ K LL E Sbjct: 2161 QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRL------QLEETDHQKN-------LLDE 2207 Query: 2859 ECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIASE 2918 E LKA +++ S + E S Q E+ + I +E Sbjct: 2208 ELQRLKAEAT-EAARQRSQVEEELFSVRVQMEELSKLKAR----------------IEAE 2250 Query: 2919 GRGE--ESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEER 2976 R + T F ++ ++ V E ++ + E ++Q++E L ++ Sbjct: 2251 NRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQ------EAARLRQLAEEDLAQQ 2304 Query: 2977 KAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAA 3036 +A K L KMQ +EA + LL Q+ +E++ L Sbjct: 2305 RALAE-----KMLKEKMQAVQEATRLKAEAE-----------LLQQQKELAQEQARRLQE 2348 Query: 3037 FRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGR 3096 + ++ + G LE Q Q +E A E L+ R + +S QA A+ + + Sbjct: 2349 DKEQMAQQLAEETQGFQRTLEAERQRQ-LEMSAEAERLKL--RVAEMSRAQA-RAEEDAQ 2404 Query: 3097 KITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAEL 3156 + + E+ EK + E Q+K + + ++++ A L+E +AEL Sbjct: 2405 RFRKQAEEIGEKLHRT--ELATQEKVTLVQTLEIQRQQSDHDAERLRE-------AIAEL 2455 Query: 3157 KSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWAL 3216 + E + KL+ E L LK E ++ + E L + SE+ + + + Sbjct: 2456 ERE--KEKLQQEAKLL----QLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFI 2509 Query: 3217 EKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLY 3276 E+EKAKL + + + + + L+ + Q+Q+ +EQ++Q L S + E++R + Sbjct: 2510 EQEKAKLEQLFQDEVAKAQQLREEQQRQQQQ-------MEQERQRLVASME--EARRRQH 2560 Query: 3277 DAQ----LSEEQGRNLELQ-----VLLESEKVRIREMSSTLDRERE---LHAQLQSSDGT 3324 +A+ +E+ + LE Q LL E R+RE L+ + H++ ++ Sbjct: 2561 EAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQV 2620 Query: 3325 GQSRPPLPSEDLLKELQKQLEEKHS 3349 ++ D L + E +HS Sbjct: 2621 AATKTLPNGRDALDGPAAEAEPEHS 2645 Score = 141 bits (356), Expect = 1e-32 Identities = 365/1881 (19%), Positives = 749/1881 (39%), Gaps = 298/1881 (15%) Query: 417 DIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALR 476 DI ++E R + +LR LD+ ++ Q + Q AQ E+E + Sbjct: 991 DIRLQLEACETRTVHRLRLPLDKEPARECAQ---RIAEQQKAQ---------AEVEGLGK 1038 Query: 477 SYSNITVNEDQIKLM---NVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQ---RQL 530 + ++ +++ + + A L +L+ T + E+++ + LE+ + R Sbjct: 1039 GVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGT 1098 Query: 531 EDLVEELSFSREQIQRARQ---TIAEQES------KLN-EAHKSLSTVEDLKAEIVSASE 580 + E L EQ++ A+ T+ E E+ KL +A T + L+ E+ A E Sbjct: 1099 QGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQE 1158 Query: 581 SRKELELKH---EAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEEL 637 + L+ +H + EV ++ ++ L + AVL + + ++ ELE+L QL + E Sbjct: 1159 VGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQ-TDVRQRELEQLGRQLRYYRESAD 1217 Query: 638 ---SKLKEDLEIEHRINIEKLKDNLGIHYK-QQIDGLQNEMS---QKIETMQ-FEKDNLI 689 + L++ + +I L D+ + + +Q L E+ +K+E Q F K + Sbjct: 1218 PLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYIN 1277 Query: 690 TKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQE----V 745 ++ + ++ L+ +K ++ + +E LR E TL + + Sbjct: 1278 AIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFI 1337 Query: 746 QELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIF 805 E + E E+ +++ + +E+ A++EA L+ +++ E + +E + Sbjct: 1338 SETLRRMEEEERLAEQQRAEERERLAEVEAA---LEKQRQLAEAHAQAKAQAEREAK--- 1391 Query: 806 LDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQ 865 ++ + ++ V +E E D +QQ + EE+++ R + +E + ++ + Sbjct: 1392 --ELQQRMQEEVVRRE-----EAAVDAQQQKRSIQEELQQLRQS---SEAEIQAKARQAE 1441 Query: 866 EEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVA 925 L++++++ + + E + + A E LQ + + + A Sbjct: 1442 AAERSRLRIEEEIRVVRLQLEATERQRGGAEGE---LQALRARAEEAE-----------A 1487 Query: 926 ETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQ 985 + + E E+ ++ ++ + ++ ++EL+ R+ +E ++K + L E L+ Sbjct: 1488 QKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE----LRL 1543 Query: 986 EKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEE 1045 + E+ R R+ E+ RA VQ + R AE + SF E+ Sbjct: 1544 QAEEAERRLRQAEV----ERARQVQVA-----------LETAQRSAEAELQSKRASFAEK 1588 Query: 1046 SKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSE 1105 + + E S QE+ + + + +E+ RA Q +E ++ ++E +E Sbjct: 1589 TAQL-------------ERSLQEEHVA--VAQLREEAERRAQQQAEAERAREE-----AE 1628 Query: 1106 QNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIH 1165 + R Q++A + + V Q + + E +K +EE +E ++ Sbjct: 1629 RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQ-----------KEEAEREARRRG 1677 Query: 1166 QLELQTMKTQETGDEG--KPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVN 1223 + E Q ++ +E ++ K L G Q+ ++ E L+ E Sbjct: 1678 KAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELI--------------RLRAETE 1723 Query: 1224 AEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQ 1283 +++ + E E LQ ++ + L KV E LL SK + Sbjct: 1724 QGEQQRQ---LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLA-----SKARAE 1775 Query: 1284 QTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQEL 1343 + E ++ L E F + + L + K + + L + Q E Sbjct: 1776 EESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ----RQLAEEDAARQRAEA 1831 Query: 1344 ESLISSLQQQLKE-TEQNYEAEIHCLQK-----RLQAVSESTVPPSLPVDSVVIT-ESDA 1396 E +++ + E T EAEI +K RL+ ++E ++ ++D Sbjct: 1832 ERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI 1891 Query: 1397 QRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFA 1456 + + + ++K D +E + G+ E+T + + Q+EEE+ + S A A Sbjct: 1892 EERL---AQLRKASDSELE--RQKGLVEDT-------LRQRRQVEEEILALKASFEKAAA 1939 Query: 1457 QQTELS----RISGGKENTASSK---------QAHAVCQQEQHY------------FNEM 1491 + EL RI E+T SK Q ++E+ E Sbjct: 1940 GKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 1999 Query: 1492 KLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDI--PESKDCVLTIS 1549 Q + + E + K +E + + E +++ L+ E K + Sbjct: 2000 AARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQ 2059 Query: 1550 EEMFSKDKTFIVRQSIHDEISVSSMDASR--------QLMLNEEQLEDMRQ----ELVRQ 1597 ++ +T QS+ D++ + A R ++ E + RQ E ++Q Sbjct: 2060 QKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQ 2119 Query: 1598 YQEHQQATELLRQAHMRQMERQREDQ--EQLQEEIKRLNRQLAQRSSIDNENLVSE---R 1652 E Q QA ++ ++ E + + Q E L ++ A + ++ +E R Sbjct: 2120 SAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLR 2179 Query: 1653 ERVLLE-ELEALK-QLSLAGREK--LCCELRNSSTQTQNGNENQGEVEEQTFKEKELDRK 1708 ++ +E EL L+ QL +K L EL+ + + +VEE+ F + + Sbjct: 2180 QKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE 2239 Query: 1709 PEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSAS 1768 + I + R + + + + L E + V E R S +Q +A Sbjct: 2240 LSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAAR-------LSVAAQEAAR 2292 Query: 1769 LIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRS 1828 L +E + + + + E+ + +++ + + +++ ++ EL+Q R Sbjct: 2293 LRQLAEEDLAQQRALAEKMLKEKMQAVQEATR-------LKAEAELLQQQKELAQEQAR- 2344 Query: 1829 GFAGTEIDPENEELMLNISSRLQAAVEKLLEAIS----ETSSQLEHAKVTQTELMRESFR 1884 + + E++ ++ Q ++ LEA E S++ E K+ E+ R R Sbjct: 2345 -----RLQEDKEQMAQQLAEETQG-FQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQAR 2398 Query: 1885 QKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDI 1944 +++A K EE+ E+LH A ++ + E Q Q+ Sbjct: 2399 AEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT--------------LEIQRQQSDHD 2444 Query: 1945 IDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKE 2004 +RL + + ELE E++++Q+E +LL + E M+ ++QLLQET+ L + Sbjct: 2445 AERLREAIA-------ELEREKEKLQQEAKLLQLKSEEMQTVQ---QEQLLQETQALQQS 2494 Query: 2005 KLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEK 2064 L +D L ++ E +E++ ++ +L Q++ + LR++ Q ++Q+E+ Sbjct: 2495 FL-------SEKDSLLQR----ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2543 Query: 2065 MRKFL---DEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEK 2121 R+ L E+A R+HE + + Q+ QQL E Q R+ E+L L E+ Sbjct: 2544 ERQRLVASMEEARRRQHEAEEGVRRKQEELQQL----------EQQRRQQEEL---LAEE 2590 Query: 2122 TDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVEDRKHFGAVEAKPELSLEV 2181 + E L E+ R +EE+ + V + D A EA+PE S + Sbjct: 2591 NQRLREQLQLLEEQHRAALAHSEEVTASQ--VAATKTLPNGRDALDGPAAEAEPEHSFD- 2647 Query: 2182 QLQAERDAIDRKEKEITNLEE 2202 L+ + A +E I + EE Sbjct: 2648 GLRRKVSAQRLQEAGILSAEE 2668 Score = 139 bits (349), Expect = 7e-32 Identities = 361/1895 (19%), Positives = 769/1895 (40%), Gaps = 224/1895 (11%) Query: 424 QETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITV 483 QE +LE L ++ Q V MK L Q + + ++ +RS+S T Sbjct: 866 QEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQL-----------IRSWSLATF 914 Query: 484 NEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQ 543 + + A++ L + Q + + G E++ +R+ S +Q Sbjct: 915 RTLKPEEQRQALHSLELHYQAFLRDSQ---DAGGFGPEDRLMAEREYGSC----SHHYQQ 967 Query: 544 IQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEML 603 + ++ + A++ES+ + +S ++D++ ++ A E+R T ++++L + Sbjct: 968 LLQSLEQGAQEESR---CQRCISELKDIRLQL-EACETR-----------TVHRLRLPLD 1012 Query: 604 EKEKNAVLDRMAESQ--EAELERLRTQL--LFSHEEELSKLKEDLEIEHRINIEKLKDNL 659 ++ R+AE Q +AE+E L + L + E++ L E + E L Sbjct: 1013 KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSEL---EL 1069 Query: 660 GIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQ--------SLVN 711 + +Q+ L +K++T+ + L +LK+ Q Sbjct: 1070 TLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATK 1129 Query: 712 SKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFA 771 + +++ Q Q + LR E + + + +Q+ + ++ ++ +E+ L E++ Sbjct: 1130 ASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQ 1189 Query: 772 QLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEIL-IEENE 830 + A+ + + E + L L+ + S + +L + + +++I+ + + +++ Sbjct: 1190 AVLAQTDVRQRELEQLGRQLRYYRE-SADPLGAWLQDARRR------QEQIQAMPLADSQ 1242 Query: 831 DLKQQCIQ---LNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQEL 887 +++Q Q L EEIE+ ++ + +++ L+ K LE + + Sbjct: 1243 AVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAK- 1301 Query: 888 EYKSKLKALNEELHLQRINPTTVKMK-SSVFDEDKTFVAETLEMGEVVEKDTTELMEKLE 946 K K+++ +E + + ++ T + +++ + F++ETL E E+ L E+ Sbjct: 1302 --KPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER----LAEQQR 1355 Query: 947 VTKREKLELSQRLSDLSEQLKQKHGEISFLNE-EVKSLKQEKEQVSLRCRELEIIINHNR 1005 +RE+L + + QL + H + E E K L+Q ++ +R RE + + Sbjct: 1356 AEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR-REEAAVDAQQQ 1414 Query: 1006 AENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEES 1065 ++Q Q+ + + +R AE + E S++ +E+++ + + Sbjct: 1415 KRSIQEELQQLRQSSEAEIQAKARQAEAA---------ERSRLRIEEEIRVVRLQLEATE 1465 Query: 1066 KQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYS 1125 +Q L +LRA +E + QK ++E+ ++Q E+QR + V Sbjct: 1466 RQRGGAEGEL------QALRAR--AEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVEL 1517 Query: 1126 THVDQVREYMENEKDKALCSLKEELIFAQEEKIK----ELQKIHQLELQTMKTQETGDEG 1181 + EK +AL +L+E + A+E + + E+++ Q+++ Q + + Sbjct: 1518 ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE-- 1575 Query: 1182 KPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPE 1241 +LQ + Q S+ E+ A E + + E+ E Sbjct: 1576 -------AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAE 1628 Query: 1242 LQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEE 1301 + R++++ + L + + L + K ++ + + E+ + + E Sbjct: 1629 RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRE 1688 Query: 1302 TEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNY 1361 + Q E + +L++ Q+L + + E + E + + L+++L ++ Sbjct: 1689 LAEQELEKQRQLAEG---TAQQRLAAEQELIRLRAETEQGEQQRQL--LEEELARLQREA 1743 Query: 1362 EAEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFG 1421 A QKR + +E + + V+ S A+ S +K+ +G F Sbjct: 1744 AA---ATQKRQELEAELA---KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFR 1797 Query: 1422 -VKEETNIVKLL--EKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAH 1478 + EE ++ L E + Q QL EE A + A A++ +++ E T +A Sbjct: 1798 ELAEEAARLRALAEEAKRQRQLAEEDA----ARQRAEAERVLAEKLAAIGEATRLKTEAE 1853 Query: 1479 AVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDI 1538 ++++ ++ + FQ + L ++ +H DI Sbjct: 1854 IALKEKEAENERLRRLAEDEAFQR------------RRLEEQAAQHKA----------DI 1891 Query: 1539 PESKDCVLTISEEMFSKDKTFI---VRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELV 1595 E + S+ + K + +RQ E + ++ AS + + ++ + Sbjct: 1892 EERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRI 1951 Query: 1596 RQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERV 1655 R A + LR ++E R+ Q +EE +R + + S+ E + + + Sbjct: 1952 RS-----NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA 2006 Query: 1656 LLEELEALKQLSLAGREKLCCELRNSSTQTQNGNEN-----QGEVEEQTF----KEKELD 1706 LEE+E LK R + S+ Q Q E Q E + F KE+EL Sbjct: 2007 ALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQ 2066 Query: 1707 R--KPEDVPPEILSNE----RYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRS 1760 + + E + L E R A ++A ++ E ++ VEE L +S Sbjct: 2067 QTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER------LKQS 2120 Query: 1761 SKSQSSASLIWRSEAEASVKSCVHEEHTRVTDE--SIPSYSGSDMPRNDINMWSKVT-EE 1817 ++ Q+ A ++ AE K E R E ++ +D +++ T + Sbjct: 2121 AEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ 2180 Query: 1818 GTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTE 1877 ++ Q L E D + + L+ RL+A + S+ +L +V E Sbjct: 2181 KAQVEQELTTLRLQLEETDHQ-KNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE 2239 Query: 1878 LMRESFR-QKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFER 1936 L + R + + L+ ++ + L EE+ +Q+A E ++ A + L E Sbjct: 2240 LSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE 2299 Query: 1937 QIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQ 1996 + ++ + +++ +E + A L+AE + +Q+++EL Q ++ + + QQL + Sbjct: 2300 DLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAE 2359 Query: 1997 ETEKLMK-------EKLEVQCQAEKVR--------------DDLQKQVKALEIDVEEQVS 2035 ET+ + +LE+ +AE+++ +D Q+ K E ++ E++ Sbjct: 2360 ETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE-EIGEKLH 2418 Query: 2036 RFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLK 2095 R QEK T + L Q Q + E++R+ + E E E++ QQE + L QLK Sbjct: 2419 RTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAEL----EREKEKLQQEAKLL--QLK 2472 Query: 2096 VVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKE----QLQRDIQERNEEIEKL-- 2149 E QT + EQL ++T + LS++ Q +R I++ ++E+L Sbjct: 2473 S-------EEMQTVQQEQLL----QETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQ 2521 Query: 2150 -----EFRVRELEQALLVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQL 2204 ++RE +Q + + + A E + Q +AE + + RK++E+ LE+Q Sbjct: 2522 DEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAE-EGVRRKQEELQQLEQQR 2580 Query: 2205 EQFREELENKNEEVQQLHMQLEIQKKESTTRLQEL 2239 Q E L +N+ +++ LE Q + + +E+ Sbjct: 2581 RQQEELLAEENQRLREQLQLLEEQHRAALAHSEEV 2615 Score = 125 bits (315), Expect = 6e-28 Identities = 335/1644 (20%), Positives = 647/1644 (39%), Gaps = 231/1644 (14%) Query: 2109 REVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEF-RVRELEQALLVEDRKH 2167 RE ++H ++ + + + QR I E + +LE R + + L D++ Sbjct: 956 REYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEP 1015 Query: 2168 FGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEI 2227 A E ++ + + QAE + + K + L + E+ L + L +LE+ Sbjct: 1016 --ARECAQRIAEQQKAQAEVEGLG---KGVARLSAEAEKVLA-LPEPSPAAPTLRSELEL 1069 Query: 2228 QKKESTTRLQELEQENKLFKDDMEKLGLAIKESD-AMSTQDQHVLFGKFAQIIQEKEVEI 2286 + +L+++ + ++ + ++ + L I+ + A H K AQ + E+ Sbjct: 1070 ----TLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPEL 1125 Query: 2287 DQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNE 2346 + + KL+ Q + + + +R + E L R+ E+E+ E Sbjct: 1126 EATKASLKKLRAQAE--AQQPTFDALRDELRGAQEVGERLQQRHG----ERDVEVERWRE 1179 Query: 2347 VIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKL-ALEQQVETANEEMTFMK 2405 + +L + + +T + L + L++ + A+ L A Q E++ M Sbjct: 1180 RVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRES--ADPLGAWLQDARRRQEQIQAMP 1237 Query: 2406 NVLKETNFKMNQLTQE---LFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLT 2462 L ++ QL QE L ++R E VE+ Q + +N D+ EL++V Sbjct: 1238 --LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY------ELQLVTY 1289 Query: 2463 EDALKSLENQTYFKSFEENGKGSII----NLETRLLQLESTVSAKDLELTQCYKQIKDMQ 2518 + L+ + + K ++G S+I +L T +L + S +++ +++++ + Sbjct: 1290 KAQLEPVASPAK-KPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEE 1348 Query: 2519 EQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNI 2578 + Q++ +++ E V AAL Q QL AK +E E + Sbjct: 1349 RLAE------QQRAEERERLAE--VEAALEKQRQLAEAHAQAK-------AQAEREAKEL 1393 Query: 2579 QNLNQ---LREDELGSDISALTLRISELESQVVEMHTSLILEK-EQVEIAEKNVLEKEKK 2634 Q Q +R +E D I E Q+ + + I K Q E AE++ L E++ Sbjct: 1394 QQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEE 1453 Query: 2635 LLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATK 2694 + ++ LE E+++ G EL+ALRA + + Sbjct: 1454 IRVVRLQLEATERQR---------------------------GGAEGELQALRARAEEAE 1486 Query: 2695 AELASYKEKAEKLQEELLVKETNMTSLQKDL-SQVRDHLAEAKEKLSILEKEDETEVQES 2753 A+ +E+AE+L+ ++ + + +L S+V+ A+EK L+ +E +Q Sbjct: 1487 AQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAE 1546 Query: 2754 KKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGI-QINLQSECSSEEVTEI 2812 + ++ ++ Q L+ + + ++ K A + Q E S +E Sbjct: 1547 EAERRLRQAEVERAR----QVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVA 1602 Query: 2813 ISQFTEKIEKMQELHA-AEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLR 2871 ++Q E+ E+ + A AE E+ E LK + ++L EE K++ Q Sbjct: 1603 VAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEA 1662 Query: 2872 SKEGSSIPE------LAHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESE 2925 K+ A A + RE+ + +EG ++ Sbjct: 1663 EKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ-------------LAEGTAQQRL 1709 Query: 2926 SATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSI-----QQVSEPWLEERKAYI 2980 +A + LRA +G Q L E + + + +Q E L + +A + Sbjct: 1710 AAEQELIR-----LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEM 1764 Query: 2981 NTISSLK--------DLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSV 3032 + + K K + + EAE + E + R A +Q L E Sbjct: 1765 EVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDA 1824 Query: 3033 LLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQK-----ADRRSLLSEIQ 3087 E A+G L+ + E +A E L++ A +R L E Sbjct: 1825 ARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA 1884 Query: 3088 ALH-AQMNGRKITLKREQESEKPSQE-LLEYNIQQKQSQMLEMQVELSSMKDRATELQEQ 3145 A H A + R L++ +SE Q+ L+E ++Q++ +++ E+ ++K Sbjct: 1885 AQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRR----QVEEEILALK--------- 1931 Query: 3146 LSSEKMVV--AELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLA 3203 S EK AEL+ EL + + E TL++ K ELEA R A Sbjct: 1932 ASFEKAAAGKAELELELGRIRSNAEDTLRS--KEQAELEAARQR------------QLAA 1977 Query: 3204 SEQKKSRELQWALEKEKA---KLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQ 3260 E+++ RE + ++K A + R + EE+E LK +E ++ + +Q Q Sbjct: 1978 EEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQ 2037 Query: 3261 LLNESQQK---IESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDREREL--- 3314 L E+ QK E + + Q E+ ELQ L+ E+ + ++ + R Sbjct: 2038 LAQEAAQKRLQAEEKAHAFAVQQKEQ-----ELQQTLQQEQSVLDQLRGEAEAARRAAEE 2092 Query: 3315 --HAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIV----ELLNETEKYKLDSLQT 3368 A++Q+ QSR + + LK+ ++ + ++ +L E E+ Q Sbjct: 2093 AEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQA 2152 Query: 3369 RQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRL 3428 Q + +Q ++ ++ + ++ +++ ++ L+ QLEE Q LD E QRL Sbjct: 2153 EQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRL 2212 Query: 3429 QGIMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYA 3488 + E +Q + EE+ S R+ + L++ L+ +IE E + Sbjct: 2213 KAEATEAARQRSQVEEELFSVRVQMEELSK---------------LKARIEAENR----- 2252 Query: 3489 KLIEMNGGGTGCNHELEMIRQKLQCVASKLQVLPQKASERLQFETADDEDFIWVQENIDE 3548 LI + T L+ +K++ VA + L A E + +ED + Q + E Sbjct: 2253 ALILRDKDNT--QRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED-LAQQRALAE 2309 Query: 3549 IILQLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKL 3608 +L+ E+ V +T + E LL+Q EL ++ +E D M +L Sbjct: 2310 KMLK---------EKMQAVQEATRLKAEAE-LLQQQKELAQEQARRLQE--DKEQMAQQL 2357 Query: 3609 EEQIRWYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRAE--AEVY 3666 E+ + +++T L + +++E E + ++ RAE A+ + Sbjct: 2358 AEETQGFQRT-----------LEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRF 2406 Query: 3667 KLKAELRNDSLLQTLSPDSEHVTL 3690 + +AE + L +T E VTL Sbjct: 2407 RKQAEEIGEKLHRTELATQEKVTL 2430 Score = 48.5 bits (114), Expect = 1e-04 Identities = 142/683 (20%), Positives = 274/683 (40%), Gaps = 64/683 (9%) Query: 3052 LLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNG---RKITLKREQESEK 3108 LL LEQ QE+ C + +SE++ + Q+ R + R ++ Sbjct: 968 LLQSLEQGAQEES-------RC------QRCISELKDIRLQLEACETRTVHRLRLPLDKE 1014 Query: 3109 PSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQT-KLEL 3167 P++E + +Q+++Q E+ + L + +EK++ S A T + EL Sbjct: 1015 PARECAQRIAEQQKAQ-----AEVEGLGKGVARLSAE--AEKVLALPEPSPAAPTLRSEL 1067 Query: 3168 ETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSE 3227 E TL + + ++ L A LE K KT + + A E ++ E Q + Sbjct: 1068 ELTL-GKLEQVRSLSAIYLE-KLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPEL 1125 Query: 3228 ERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRN 3287 E K L+ L+ E+Q+ L L +++ QQ+ +R + + E + Sbjct: 1126 EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQR-HGERDVEVERWRERVAQL 1184 Query: 3288 LEL-QVLLESEKVRIREMSST---LDRERE----LHAQLQSSDGTGQSRPPLPSEDLLKE 3339 LE Q +L VR RE+ L RE L A LQ + + +P D + Sbjct: 1185 LERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADS-QA 1243 Query: 3340 LQKQLEEKHSRIVELLNETEKYKLDSLQTRQQME--KDRQVHRKTLQTEQEANTEGQKKM 3397 +++QL ++ + + E+ EK + +Q + KD ++ T + + E KK Sbjct: 1244 VREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKP 1303 Query: 3398 HELQSKVEDLQRQLEEKRQQVYKLD-LEGQRLQGIMQEFQKQELEREEKRESRRILYQNL 3456 ++QS E + ++ + R +L L Q ++ I + ++ E E + R + L Sbjct: 1304 -KVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERL 1362 Query: 3457 NEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMI--RQKLQCV 3514 E +L R + + + + + AK ++ E + +Q+ + + Sbjct: 1363 AEVEA-ALEKQRQ---LAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSI 1418 Query: 3515 ASKLQVLPQKASERLQFET----ADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSPS 3570 +LQ L Q + +Q + A + + ++E I + LQL+ Q+G + Sbjct: 1419 QEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL 1478 Query: 3571 TSCGSLTERLLRQNAELTGHIS-QLTEEKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRFS 3629 + E RQ E + Q+ +E R ++L +++ + A R+ Sbjct: 1479 RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVK--AEAEAAREKQRALQ 1536 Query: 3630 LNGGANIEAIIA------SEKEVWNREKLTLQKSLKRAEAEVYKLKAELRNDSLLQTLSP 3683 ++A A +E E + ++ L+ + + AEAE+ +A + S Sbjct: 1537 ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1596 Query: 3684 DSEHVTLKRIYGKYLRAESFRKA 3706 EHV + + LR E+ R+A Sbjct: 1597 QEEHVAVAQ-----LREEAERRA 1614 Score = 35.8 bits (81), Expect = 0.85 Identities = 52/235 (22%), Positives = 101/235 (42%), Gaps = 31/235 (13%) Query: 2138 DIQE--RNEEIEKLEFRVRELEQALLVEDRKHFGAVEAK--PELSLEVQLQAERDAIDRK 2193 D+Q+ R E++ REL LL R H A E + P E+++ + + K Sbjct: 267 DVQDGVRANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQ-FLKFK 325 Query: 2194 EKEITNLEEQLEQFREELENKNEEVQQLHMQ-------LEIQKKESTTRLQELEQENKLF 2246 E E+ E + + ++ VQ ++ L+++K+ + LE+E +L Sbjct: 326 EMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQL- 384 Query: 2247 KDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDN 2306 + + E+L Q ++ ++ E + +QLN+ LQ +++ Sbjct: 385 RSEFERLECL-----------QRIV----TKLQMEAGLCEEQLNQADALLQSDVRLLAAG 429 Query: 2307 KVIEEKNELIRDL---ETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANI 2358 KV + E+ RDL ++ I L +D + +K R + EQ+ + +L + L I Sbjct: 430 KVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAI 484 Score = 35.8 bits (81), Expect = 0.85 Identities = 60/292 (20%), Positives = 111/292 (38%), Gaps = 39/292 (13%) Query: 4 EERQKKLEAGKAKLAQFR-------QRKAQSDGQ-----SPSKKQKKKRKTSSSKHDVSA 51 +E+ ++L+ K ++AQ QR +++ Q S ++ K R S+ A Sbjct: 2340 QEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA 2399 Query: 52 HHDLNIDQSQCNEMYINSSQRVESTVIPESTIMRTLH-SGEITSHEQGFSVELESEISTT 110 D + Q E+ R E + T+++TL + + H+ E +E+ Sbjct: 2400 EEDAQRFRKQAEEIG-EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELERE 2458 Query: 111 ADDCSSEVNGCSFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHE 170 + E K L EE V Q Q + L ++ Sbjct: 2459 KEKLQQEA----------KLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERF 2508 Query: 171 IEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLE 230 IE+ +LE++ + Q +E + +Q + +L A++++ARR + E Sbjct: 2509 IEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRR 2568 Query: 231 LTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDH 282 E+ Q+L+ Q +Q + +LL + Q L Q QL E+ H Sbjct: 2569 KQEELQQLEQQRRQQE---------------ELLAEENQRLREQLQLLEEQH 2605 >gi|41322910 plectin 1 isoform 7 [Homo sapiens] Length = 4515 Score = 192 bits (487), Expect = 7e-48 Identities = 274/1260 (21%), Positives = 544/1260 (43%), Gaps = 171/1260 (13%) Query: 1579 QLMLNEEQLEDMRQE---LVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNR 1635 +++ EE D +Q+ + + Q+ +Q++E QA RQ E + +++EEI+ + Sbjct: 1368 EVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRL 1427 Query: 1636 QLA----QRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNEN 1691 QL QR + E + R EE EA K+ + E+L ++++ S Q + Sbjct: 1428 QLEATERQRGGAEGE---LQALRARAEEAEAQKRQAQEEAERLRRQVQDES---QRKRQA 1481 Query: 1692 QGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGR 1751 + E+ + E E R+ + + L R ++A RL + +E + ET Sbjct: 1482 EVELASRVKAEAEAAREKQRAL-QALEELRLQAEEAERRLRQAEVERARQVQVALETA-- 1538 Query: 1752 HVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMW 1811 RS++++ + +E A ++ + EEH V Sbjct: 1539 ------QRSAEAELQSKRASFAEKTAQLERSLQEEHVAV--------------------- 1571 Query: 1812 SKVTEEGTELSQRLVRSGFAGTEIDPENE--ELMLNISSRLQAAVEKLLEAISETSSQLE 1869 +++ EE +Q+ + A E + E E +L N + RL+ E++ + S ++ E Sbjct: 1572 AQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE 1631 Query: 1870 HAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYAD 1929 K E RE+ R+ + ++++ +E + L ++ + E A + AE + Sbjct: 1632 KQK---EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRA 1688 Query: 1930 EKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELL------------- 1976 E E+Q Q + + RL++E A+ + QELEAE +++ E E+L Sbjct: 1689 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS 1748 Query: 1977 --SRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQV 2034 + K+ ++AEAG ++L +E +L E + Q + +D +Q E + E++ Sbjct: 1749 TSEKSKQRLEAEAGRF-RELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKL 1807 Query: 2035 SRFIE---LEQEKNTELMDLRQQNQALEKQLEK---MRKFLDEQAIDREHERDVFQQEIQ 2088 + E L+ E L + +N+ L + E R+ L+EQA +H+ D+ ++ Q Sbjct: 1808 AAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA--AQHKADIEERLAQ 1865 Query: 2089 KLEQQLKVVPRFQPISE---HQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEE 2145 + + R + + E Q R+VE+ LK +K + K +L+ ++ Sbjct: 1866 LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAA---AGKAELELELGRIRSN 1922 Query: 2146 IEKLEFRVRELEQALLVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLE 2205 E +R EQA L R+ A E + + R+A +R +K + EE Sbjct: 1923 AED---TLRSKEQAELEAARQRQLAAEEE---------RRRREAEERVQKSLAAEEEAAR 1970 Query: 2206 QFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMST 2265 Q + L EEV++L ++E ++ QE ++ +L ++ +K A +++ A + Sbjct: 1971 QRKAAL----EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAV 2026 Query: 2266 QDQHVLFGKFAQIIQEKEVEIDQLNEQV------------TKLQQQLKITTDNKVIEEKN 2313 Q + + Q +Q+++ +DQL + ++Q + + + +EE Sbjct: 2027 QQKE---QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAE 2083 Query: 2314 ELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEA 2373 L + E Q + Q ++ R+E + E + Q E A + QK + +A E Sbjct: 2084 RLKQSAEEQAQARAQAQAAAEKLRKEAEQ---EAARRAQAEQAALRQKQAADA-----EM 2135 Query: 2374 DSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVE 2433 + K + + +K +EQ E+T ++ L+ET+ + N L +EL LK E Sbjct: 2136 EKHKKFAEQTLRQKAQVEQ-------ELTTLRLQLEETDHQKNLLDEELQRLKAEATEAA 2188 Query: 2434 KIQSIPEN---SVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLE 2490 + +S E SV V ++ LSK K +E L+ +N F EE K + E Sbjct: 2189 RQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQ-EEAEKMKQVAEE 2247 Query: 2491 TRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQ 2550 L + + +A+ +L + +D+ +Q +ML++K+ +Q+ K A L+ Q Sbjct: 2248 AARLSVAAQEAARLRQLAE-----EDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQ 2302 Query: 2551 IQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQL------REDELGSDISALTLRISEL- 2603 Q E QE A+ Q+++ ++ Q + R+ E+ ++ L LR++E+ Sbjct: 2303 -QKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMS 2361 Query: 2604 -----------------ESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNE 2646 E ++H + + +E+V + + +++++ + ++L E Sbjct: 2362 RAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIA 2421 Query: 2647 KKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAEL-------AS 2699 + +REKEK + Q+ ++L+ +E + ++ E +AL+ ++ K L Sbjct: 2422 ELEREKEKLQ--QEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQ 2479 Query: 2700 YKEKAEKLQEELLVKETNMTS----LQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKK 2755 K K E+L ++ + K + Q+ + Q R L + E+ + E E V+ ++ Sbjct: 2480 EKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQE 2539 Score = 171 bits (433), Expect = 1e-41 Identities = 345/1688 (20%), Positives = 693/1688 (41%), Gaps = 223/1688 (13%) Query: 1837 PENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQ 1896 PE + S L+ + KL + S ++ LE K + R Q A E L+ Sbjct: 1022 PEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVI-----RGTQGAEEVLRAH 1076 Query: 1897 EELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCAS 1956 EE + +E AV + E + +K + + Q+ T D L EL A Sbjct: 1077 EE---------QLKEAQAVPATLPELEATKASLKKLRAQAEAQQPT--FDALRDELRGA- 1124 Query: 1957 NRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVR 2016 QE+ QQ ER++ + A+ Q +L +T+ +E ++ Q R Sbjct: 1125 ---QEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYR 1181 Query: 2017 DDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDE-QAID 2075 + L+ D + + + + + + +Q QAL +++E+ + ++E Q Sbjct: 1182 ESADPLGAWLQ-DARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFA 1240 Query: 2076 REHERDVFQQEIQKL--EQQLKVV------PRFQPISEHQTREVEQLANHLKEKTDKCSE 2127 +++ + E+Q + + QL+ V P+ Q SE +E L H E T S+ Sbjct: 1241 KQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQ 1300 Query: 2128 LL--LSKEQLQRDIQERNEEIEKLEFRVRELEQALLVEDRKHFGAVEAKPELSLEVQLQA 2185 + +S+ + + +ER E ++ E R R E +E ++ A + + QA Sbjct: 1301 YIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHA------QAKAQA 1354 Query: 2186 ERDAID---RKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQE 2242 ER+A + R ++E+ EE +++ + EE+QQL E + + + + E+ Sbjct: 1355 EREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERS 1414 Query: 2243 NKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKI 2302 ++++ + L ++ ++ + L A+ +E E + Q E+ +L++Q Sbjct: 1415 RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARA-EEAEAQKRQAQEEAERLRRQ--- 1470 Query: 2303 TTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKT 2362 ++++++ R E ++ + + R ++ ++ L E+ +LQ Sbjct: 1471 ------VQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL--RLQ---------- 1512 Query: 2363 SMNAHSLSEEADSLKHQLDVVIAEKL--ALEQQVETANEEMTFMKNVLKETNFKMNQLTQ 2420 +EEA+ Q +V A ++ ALE +A E+ + E ++ + Sbjct: 1513 -------AEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLER--- 1562 Query: 2421 ELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEE 2480 SL+ E +V +++ E + + + E E L LK+ E Sbjct: 1563 ---SLQEEHVAVAQLREEAERRAQQQAE-AERAREEAERELERWQLKANEA--------- 1609 Query: 2481 NGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQ----GQFETEMLQKKIVNLQ 2536 L RL Q E K L + KQ ++ + + G+ E + ++++ + Q Sbjct: 1610 --------LRLRL-QAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1660 Query: 2537 KIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGS---DI 2593 ++ +++ A +Q +L A QE + + +E E+ Q QL E+EL + Sbjct: 1661 ELEKQRQLAEGTAQQRLAAEQELIR-------LRAETEQGEQQR--QLLEEELARLQREA 1711 Query: 2594 SALTLRISELESQVVEMHTS---LILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQR 2650 +A T + ELE+++ ++ L+ K + E ++ EK K+ LE E ++ Sbjct: 1712 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA----EAGRFREL 1767 Query: 2651 EKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALR--AESVATKAELASYKEKAEKLQ 2708 +E R E K +L EE EA R AE +A E K +AE Sbjct: 1768 AEEAARLRALAEEAKRQRQLA---EEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIAL 1824 Query: 2709 EELLVKETNMTSLQKDLS--------QVRDHLAEAKEKLSILEKEDETEVQESK------ 2754 +E + + L +D + Q H A+ +E+L+ L K ++E++ K Sbjct: 1825 KEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDT 1884 Query: 2755 ----KACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVT 2810 + E L +K S A+ L++ I+ N + S+E Sbjct: 1885 LRQRRQVEEEILALKASFEKAAAGKAELELELGR-----------IRSNAEDTLRSKEQA 1933 Query: 2811 EIISQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCL 2870 E+ + ++ +E E + + ++ E R+ A+ EE LKA ++ Sbjct: 1934 ELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL----EEVERLKAKVEEA 1989 Query: 2871 R------SKEGSSIPELAHSDAY---QTREICSSDSGSDWGQGIYLTHSQGFDIASEGRG 2921 R +E + +LA A Q E + + Q + T Q + + RG Sbjct: 1990 RRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRG 2049 Query: 2922 EESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYIN 2981 E +E+A + A E +V + E+ S + +++ + E+ +A Sbjct: 2050 E-AEAARRA----------AEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQ 2098 Query: 2982 TISSLKDLITKMQLQ--REAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRT 3039 ++ + L + + + R A+ ++ + +D E + L +++ + T Sbjct: 2099 AQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTT 2158 Query: 3040 ELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADR-----RSLLSEIQALHAQMN 3094 L TD N L++ +Q E A + + R + E+ L A++ Sbjct: 2159 LRLQLEETDHQK--NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIE 2216 Query: 3095 G--RKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATEL---------Q 3143 R + L+ + +++ QE E K Q+ E LS A L Q Sbjct: 2217 AENRALILRDKDNTQRFLQEEAE-----KMKQVAEEAARLSVAAQEAARLRQLAEEDLAQ 2271 Query: 3144 EQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLA 3203 ++ +EKM+ ++++ T+L+ E L Q K L + +A RL+ + L +T Sbjct: 2272 QRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQG 2331 Query: 3204 S----EQKKSRELQWALEKEKAKL-----GRSEERDKEELEDLKFSLESQKQRNLQLNLL 3254 E ++ R+L+ + E E+ KL R++ R +E+ + + E ++ L L Sbjct: 2332 FQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEK-LHRTEL 2390 Query: 3255 LEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDREREL 3314 Q+K L ++ + I+ Q+ +DA+ E LE + ++ ++ ++ S + + Sbjct: 2391 ATQEKVTLVQTLE-IQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQ 2449 Query: 3315 HAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNE----TEKYKLDSLQTRQ 3370 LQ + QS L +D L + ++ +E++ +++ +L + ++ + + + +Q Sbjct: 2450 EQLLQETQALQQSF--LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQ 2507 Query: 3371 QMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQG 3430 QME++RQ + + + +EA + ++ K E+LQ+ +++RQQ L E QRL+ Sbjct: 2508 QMEQERQ---RLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLRE 2564 Query: 3431 IMQEFQKQ 3438 +Q ++Q Sbjct: 2565 QLQLLEEQ 2572 Score = 158 bits (399), Expect = 1e-37 Identities = 323/1676 (19%), Positives = 685/1676 (40%), Gaps = 242/1676 (14%) Query: 153 SPTHLEMMESELAGKQHEIEELNR-ELEEMR----VTYGTEGLQQ-LQEFEAAIKQRDGI 206 +PT +E L GK ++ L+ LE+++ V GT+G ++ L+ E +K+ + Sbjct: 1028 APTLRSELELTL-GKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAV 1086 Query: 207 ITQLT------ANLQQARREKDETMREFLELTEQ---SQKLQIQFQQLQASETLRNSTHS 257 L A+L++ R + + F L ++ +Q++ + QQ + Sbjct: 1087 PATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWR 1146 Query: 258 STAADLLQAKQQILTH----QQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQD 313 A LL+ Q +L Q++LE+ L Y++ + ++LQ+ + E Q Sbjct: 1147 ERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLG---AWLQDARRRQEQIQA 1203 Query: 314 KKVENSN--KEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQ 371 + +S +E++++++ ++EE+ +K E + + + + Q+V Sbjct: 1204 MPLADSQAVREQLRQEQALLEEIE----RHGEKVEECQRFAKQYINAIKDYELQLVTYKA 1259 Query: 372 EIKNMKLELTNSKQKERQSS--EEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRK 429 +++ + K + S +E L EL + +F ++ ++RME+E +R Sbjct: 1260 QLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEE-ERL 1318 Query: 430 LEQLRAE-----------------LDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEME 472 EQ RAE L E + Q Q ++E EE+ R + ++ Sbjct: 1319 AEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVD 1378 Query: 473 NALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKE---KLKEELGLI---LE----- 521 + S + E+ +L + E+ K + + + +++EE+ ++ LE Sbjct: 1379 AQQQKRS---IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQ 1435 Query: 522 ------EKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEI 575 E AL+ + E+ + ++E+ +R R+ + ++ + +A L++ +KAE Sbjct: 1436 RGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELAS--RVKAEA 1493 Query: 576 VSASESRKEL----ELKHEAEVTNYKIKLEMLEKEK--NAVLDRMAESQEAELERLRTQL 629 +A E ++ L EL+ +AE +++ +E+ + L+ S EAEL+ R Sbjct: 1494 EAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRA-- 1551 Query: 630 LFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDG--LQNEMSQKIETMQFEKDN 687 S E+ ++L+ L+ EH + + +L++ +QQ + + E +++E Q + + Sbjct: 1552 --SFAEKTAQLERSLQEEH-VAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANE 1608 Query: 688 LITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTL-EQEVQ 746 + + Q E+++ K L Q+ E +K+ E +E + +G EQ V+ Sbjct: 1609 ALRLRLQ-AEEVAQQKSLAQA--------------EAEKQKEEAEREARRRGKAEEQAVR 1653 Query: 747 ELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFL 806 + +L + LEKQ + E Q++ A AE +++ L+ T +++R + Sbjct: 1654 QRELAEQELEKQRQLAEGTAQQRLA---AEQELIR---------LRAETEQGEQQRQLLE 1701 Query: 807 DSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEI-----------EKQRNTFSFAEK 855 + + + ++E ++ ++L+ + ++ E+ E+ R+T +++ Sbjct: 1702 EEL------ARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQ 1755 Query: 856 NFEV---NYQELQEEYACLLKVKDD-------LEDSKNKQELEYK----SKLKALNEELH 901 E ++EL EE A L + ++ E+ +Q E + KL A+ E Sbjct: 1756 RLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATR 1815 Query: 902 LQRINPTTVKMKSSVFD------EDKTFVAETLEMGEVVEKDTTELMEKL-EVTKREKLE 954 L+ +K K + + ED+ F LE E + ++ E+L ++ K E Sbjct: 1816 LKTEAEIALKEKEAENERLRRLAEDEAFQRRRLE--EQAAQHKADIEERLAQLRKASDSE 1873 Query: 955 LSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDT 1014 L ++ + + L+Q+ + EE+ +LK E+ + ELE+ + R+ + + Sbjct: 1874 LERQKGLVEDTLRQRRQ----VEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS 1929 Query: 1015 QVSSLLDG-----VVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQ 1069 + + L+ + R + +V KS E + + K + E + + +E Sbjct: 1930 KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 1989 Query: 1070 LILDHLPSVTKESSLRATQPSENDKLQKE--LNVLKSEQNDLRLQMEAQRICLSLVYSTH 1127 L L+ Q + +LQ E + +Q + LQ Q+ + Sbjct: 1990 RRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ------EQSV 2043 Query: 1128 VDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLL 1187 +DQ+R E + +A +E + A+ E + +++ + E +E Sbjct: 2044 LDQLRGEAEAAR-RAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAA 2102 Query: 1188 IGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRY 1247 KL+K +E + Q + L + + E + + E Q R Sbjct: 2103 AEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE--------------QTLRQ 2148 Query: 1248 EVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSI 1307 + Q QE + TL ++ E ++ +L L ++ + T+ + + E E S+ Sbjct: 2149 KAQVEQE-LTTLRLQLEETDHQKNLLDEELQRLKAEATEAAR------QRSQVEEELFSV 2201 Query: 1308 HSQMTNLEDID--VNHKSKLSSLQDLEKTK--LEEQVQELESL------ISSLQQQLKET 1357 QM L + + +++ L+D + T+ L+E+ ++++ + +S Q+ Sbjct: 2202 RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARL 2261 Query: 1358 EQNYEAEI--------HCLQKRLQAVSEST---VPPSLPVDSVVITESDAQRTMYPGSCV 1406 Q E ++ L++++QAV E+T L + + A+R + Sbjct: 2262 RQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM 2321 Query: 1407 KKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISG 1466 + + +E + LE + Q QLE + + +A E+SR Sbjct: 2322 AQQL-----------AEETQGFQRTLEAERQRQLEMSAEAERLKLRVA-----EMSRAQA 2365 Query: 1467 GKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGK 1526 E A + A E+ + E+ + QT E + + + L + + E + Sbjct: 2366 RAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELER 2425 Query: 1527 EILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQ 1586 E + + + + T+ +E ++ T ++QS E S + R + + + Sbjct: 2426 EKEKLQQEAKLLQLKSEEMQTVQQEQLLQE-TQALQQSFLSE-KDSLLQRERFIEQEKAK 2483 Query: 1587 LEDM-------RQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQ 1639 LE + Q+L + Q QQ E RQ + ME R Q + +E ++R +L Q Sbjct: 2484 LEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQ 2543 Query: 1640 --RSSIDNENLVSERERVLLEELEALKQ---LSLAGREKLCCELRNSSTQTQNGNE 1690 + E L++E + L E+L+ L++ +LA E++ ++ NG + Sbjct: 2544 LEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRD 2599 Score = 151 bits (382), Expect = 1e-35 Identities = 318/1657 (19%), Positives = 679/1657 (40%), Gaps = 234/1657 (14%) Query: 1992 QQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDL 2051 QQLLQ E+ +E+ Q +++D ++ Q++A E ++ + L++E E Sbjct: 934 QQLLQSLEQGAQEESRCQRCISELKD-IRLQLEACETRTVHRLR--LPLDKEPARECAQR 990 Query: 2052 RQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREV 2111 + Q + ++E + K + + + E ++ L + P + E ++ Sbjct: 991 IAEQQKAQAEVEGLGKGVARLSAEAE--------KVLALPEPSPAAPTLRSELELTLGKL 1042 Query: 2112 EQLANHLKEKTDKCSELLL------SKEQLQRDIQERNEEIEKLEFRVRELEQALLVEDR 2165 EQ+ + +K + L E++ R +E+ +E + + + ELE + Sbjct: 1043 EQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKK 1102 Query: 2166 KHFGAVEAKPEL-SLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQ 2224 A +P +L +L+ ++ +R ++ + ++E++RE + E Q + Q Sbjct: 1103 LRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQ 1162 Query: 2225 LEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEV 2284 +++++E L++L ++ + +++ + LG ++++ Q Q + +Q ++E+ Sbjct: 1163 TDVRQRE----LEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLAD-SQAVREQLR 1217 Query: 2285 EIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRN-REEEIEQ 2343 + L E++ + + K+ + ++ I+D E Q+ + E V ++ +++ Sbjct: 1218 QEQALLEEIERHGE--KVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQS 1275 Query: 2344 LNE-VIEKLQQELANIGQKTSMNAHSLS---------EEADSLKHQLDVVIAEKLA---- 2389 +E VI++ + + T++ + + EE + L Q E+LA Sbjct: 1276 GSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEA 1335 Query: 2390 -LEQQVETANEEMTFMKNVLKETNFKMNQLTQELF--------SLKRERESVEKIQSIPE 2440 LE+Q + A +E ++ +E+ + +++R E++Q + + Sbjct: 1336 ALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQ 1395 Query: 2441 NS-VNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENG-KGSIINLETRLLQLES 2498 +S + + E + E+ ++ + Q + G +G + L R + E+ Sbjct: 1396 SSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEA 1455 Query: 2499 TVSAKDLELTQCYKQIKD-MQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQ 2557 E + +Q++D Q + Q E E+ + + E++ A + +++L+A + Sbjct: 1456 QKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQA-E 1514 Query: 2558 EYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILE 2617 E + + + + + ++ + E EL S ++ + ++LE + E H ++ Sbjct: 1515 EAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQL 1574 Query: 2618 KEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREK----------EKKRSPQDVEVLKTT 2667 +E+ E + E E+ E ++ LE + K E +++S E K Sbjct: 1575 REEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK 1634 Query: 2668 TELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQ 2727 E G E +A+R +A + EL ++ AE ++ L E + L+ + Q Sbjct: 1635 EEAEREARRRGKAEE-QAVRQRELAEQ-ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQ 1692 Query: 2728 VRDHLAEAKEKLSILEKEDETEVQ-----ESKKACMFEPLPIKLSKSIASQTDGTLKISS 2782 +E+L+ L++E Q E++ A + + + L+ ++ + S+ Sbjct: 1693 GEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR---ST 1749 Query: 2783 SNQTPQILVKNAGIQINLQSECSS----EEVTEIISQFTEKIEKMQELHAAEILDMESRH 2838 S ++ Q L AG L E + E + Q E+ Q A +L + Sbjct: 1750 SEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAA 1809 Query: 2839 ISETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREI------ 2892 I E LK E +A LKE + E + LA +A+Q R + Sbjct: 1810 IGEATRLKTEAEIA---LKE------------KEAENERLRRLAEDEAFQRRRLEEQAAQ 1854 Query: 2893 -------------CSSDSGSDWGQGIY--------------LTHSQGFDIASEGRGEES- 2924 +SDS + +G+ L F+ A+ G+ E Sbjct: 1855 HKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELEL 1914 Query: 2925 ------ESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVS--EPWLEER 2976 +A D+ K + L A Q+ + E + E+ + ++ E +R Sbjct: 1915 ELGRIRSNAEDTLRSKEQAELEAARQR--QLAAEEERRRREAEERVQKSLAAEEEAARQR 1972 Query: 2977 KAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLA--------------- 3021 KA + + LK + + + RE +S++ + + + L A Sbjct: 1973 KAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQE 2032 Query: 3022 LQQVFLEERSVL------------------LAAFRTELTALGTTDAVGLLNCLEQRIQEQ 3063 LQQ +E+SVL A + E A + V L+Q +EQ Sbjct: 2033 LQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQ 2092 Query: 3064 G---VEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQ 3120 + QAA E L+K + QA A + ++ ++ +K +++ L Q Sbjct: 2093 AQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQV 2152 Query: 3121 KQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKE 3180 +Q ++ ++++L + L E+L K E + +Q + EL +++ Q + L + Sbjct: 2153 EQ-ELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEEL-FSVRVQMEELSK 2210 Query: 3181 LEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEK---------EKAKLGRSEERDK 3231 L+A R+E +++ + ++T Q+++ +++ E+ E A+L + E D Sbjct: 2211 LKA-RIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDL 2269 Query: 3232 EELEDLKFSLESQKQRNLQLNL-------LLEQQKQLLNESQQKIESQRMLYDAQLSEE- 3283 + L + +K + +Q LL+QQK+L E ++++ + QL+EE Sbjct: 2270 AQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEET 2329 Query: 3284 QG----------RNLELQVLLESEKVRIREMSSTLDR-ERELHAQLQSSDGTGQS--RPP 3330 QG R LE+ E K+R+ EMS R E + + ++ G+ R Sbjct: 2330 QGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTE 2389 Query: 3331 LPSEDLLK-----ELQKQ-----LEEKHSRIVELLNETEKY---------KLDSLQTRQQ 3371 L +++ + E+Q+Q E I EL E EK K + +QT QQ Sbjct: 2390 LATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQ 2449 Query: 3372 ME--KDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDL--------QRQLEEKRQQVYKL 3421 + ++ Q +++ +E+++ + ++ + + ++K+E L Q+ EE+++Q ++ Sbjct: 2450 EQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQM 2509 Query: 3422 DLEGQRLQGIMQEFQKQELEREEKRESRRILYQNLNE 3458 + E QRL M+E ++++ E EE ++ Q L + Sbjct: 2510 EQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQ 2546 Score = 147 bits (370), Expect = 3e-34 Identities = 322/1585 (20%), Positives = 651/1585 (41%), Gaps = 255/1585 (16%) Query: 1858 LEAISETSSQLEHAKVTQTELMRESFRQKQEATESLK--------CQEELRERLHEESRA 1909 L+ Q++ + ++ +RE RQ+Q E ++ CQ ++ ++ Sbjct: 1191 LQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY 1250 Query: 1910 REQLAVELSK----------------AEGVIDGYADEKT-------LFERQIQEKTDIID 1946 QL ++ +E VI Y D +T L + I+ ++ + Sbjct: 1251 ELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLR 1310 Query: 1947 RLEQELLCASN-------RLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETE 1999 R+E+E A RL E+EA ++ ++ E ++ K + EA ++Q++ +E Sbjct: 1311 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1370 Query: 2000 KLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEK---NTELMDLRQQNQ 2056 + + ++ Q Q ++++LQ+ ++ E +++ + + E+ + E+ +R Q + Sbjct: 1371 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE 1430 Query: 2057 ALEKQ---LEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQ 2113 A E+Q E + L +A + E ++ Q+E ++L +Q+ Q S+ + + + Sbjct: 1431 ATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQV------QDESQRKRQAEVE 1484 Query: 2114 LANHLKEKTDKCSE---LLLSKEQLQRDIQERNEEIEKLEF-RVRELEQALLVEDRKHFG 2169 LA+ +K + + E L + E+L+ +E + + E R R+++ AL R Sbjct: 1485 LASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA 1544 Query: 2170 AVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLE---QFREELENKNEEVQQLHMQLE 2226 +++K E Q ER ++ + + L E+ E Q + E E EE ++ + + Sbjct: 1545 ELQSKRASFAEKTAQLER-SLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ 1603 Query: 2227 IQKKESTT-RLQ--ELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKE 2283 ++ E+ RLQ E+ Q+ L + + EK KE + + GK +E+ Sbjct: 1604 LKANEALRLRLQAEEVAQQKSLAQAEAEKQ----KEEAEREARRR----GK----AEEQA 1651 Query: 2284 VEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQ 2343 V +L EQ + Q+QL T + + + ELIR L ++ E E++ + Sbjct: 1652 VRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR--------LRAETE----QGEQQRQL 1699 Query: 2344 LNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTF 2403 L E + +LQ+E A QK L E ++ +++V++A K E++ + +E+ Sbjct: 1700 LEEELARLQREAAAATQKRQ----ELEAELAKVRAEMEVLLASKARAEEESRSTSEKS-- 1753 Query: 2404 MKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVN--------------VAIDH 2449 K L+ + +L +E L+ E ++ + + E AI Sbjct: 1754 -KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGE 1812 Query: 2450 LSKDKPELEVVLTE-----DALKSLENQTYF--KSFEENGKGSIINLETRLLQLESTVSA 2502 ++ K E E+ L E + L+ L F + EE ++E RL QL A Sbjct: 1813 ATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRK---A 1869 Query: 2503 KDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKF 2562 D EL + ++D Q + ++++I+ L+ E+ A +++L ++ A+ Sbjct: 1870 SDSELERQKGLVEDTLRQRR----QVEEEILALKASFEKAAAGKAELELELGRIRSNAE- 1924 Query: 2563 CQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVE 2622 T+ S+ + L R+ +L ++ R E E +V + SL E+E Sbjct: 1925 ----DTLRSKEQA----ELEAARQRQLAAEEER---RRREAEERVQK---SLAAEEEAAR 1970 Query: 2623 IAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNE 2682 K LE+ ++L K ++ RE+ ++ S + +++ + + Sbjct: 1971 -QRKAALEEVERL----KAKVEEARRLRERAEQESARQLQLAQEAAQ------------- 2012 Query: 2683 LEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSIL 2742 + L+AE KA + ++K ++LQ+ L +++ + L+ + R EA+E Sbjct: 2013 -KRLQAEE---KAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQA 2068 Query: 2743 EKE---DETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQIN 2799 E+E +V+E+++ + + + K + + + A ++ Sbjct: 2069 EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK 2128 Query: 2800 LQSECSSEEVTEIISQ-FTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLLKE 2858 ++ E+ + Q +K + QEL + + ET+ K LL E Sbjct: 2129 QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRL------QLEETDHQKN-------LLDE 2175 Query: 2859 ECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIASE 2918 E LKA +++ S + E S Q E+ + I +E Sbjct: 2176 ELQRLKAEAT-EAARQRSQVEEELFSVRVQMEELSKLKAR----------------IEAE 2218 Query: 2919 GRGE--ESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEER 2976 R + T F ++ ++ V E ++ + E ++Q++E L ++ Sbjct: 2219 NRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQ------EAARLRQLAEEDLAQQ 2272 Query: 2977 KAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAA 3036 +A K L KMQ +EA + LL Q+ +E++ L Sbjct: 2273 RALAE-----KMLKEKMQAVQEATRLKAEAE-----------LLQQQKELAQEQARRLQE 2316 Query: 3037 FRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGR 3096 + ++ + G LE Q Q +E A E L+ R + +S QA A+ + + Sbjct: 2317 DKEQMAQQLAEETQGFQRTLEAERQRQ-LEMSAEAERLKL--RVAEMSRAQA-RAEEDAQ 2372 Query: 3097 KITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAEL 3156 + + E+ EK + E Q+K + + ++++ A L+E +AEL Sbjct: 2373 RFRKQAEEIGEKLHRT--ELATQEKVTLVQTLEIQRQQSDHDAERLRE-------AIAEL 2423 Query: 3157 KSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWAL 3216 + E + KL+ E L LK E ++ + E L + SE+ + + + Sbjct: 2424 ERE--KEKLQQEAKLL----QLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFI 2477 Query: 3217 EKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLY 3276 E+EKAKL + + + + + L+ + Q+Q+ +EQ++Q L S + E++R + Sbjct: 2478 EQEKAKLEQLFQDEVAKAQQLREEQQRQQQQ-------MEQERQRLVASME--EARRRQH 2528 Query: 3277 DAQ----LSEEQGRNLELQ-----VLLESEKVRIREMSSTLDRERE---LHAQLQSSDGT 3324 +A+ +E+ + LE Q LL E R+RE L+ + H++ ++ Sbjct: 2529 EAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQV 2588 Query: 3325 GQSRPPLPSEDLLKELQKQLEEKHS 3349 ++ D L + E +HS Sbjct: 2589 AATKTLPNGRDALDGPAAEAEPEHS 2613 Score = 141 bits (356), Expect = 1e-32 Identities = 365/1881 (19%), Positives = 749/1881 (39%), Gaps = 298/1881 (15%) Query: 417 DIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALR 476 DI ++E R + +LR LD+ ++ Q + Q AQ E+E + Sbjct: 959 DIRLQLEACETRTVHRLRLPLDKEPARECAQ---RIAEQQKAQ---------AEVEGLGK 1006 Query: 477 SYSNITVNEDQIKLM---NVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQ---RQL 530 + ++ +++ + + A L +L+ T + E+++ + LE+ + R Sbjct: 1007 GVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGT 1066 Query: 531 EDLVEELSFSREQIQRARQ---TIAEQES------KLN-EAHKSLSTVEDLKAEIVSASE 580 + E L EQ++ A+ T+ E E+ KL +A T + L+ E+ A E Sbjct: 1067 QGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQE 1126 Query: 581 SRKELELKH---EAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEEL 637 + L+ +H + EV ++ ++ L + AVL + + ++ ELE+L QL + E Sbjct: 1127 VGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQ-TDVRQRELEQLGRQLRYYRESAD 1185 Query: 638 ---SKLKEDLEIEHRINIEKLKDNLGIHYK-QQIDGLQNEMS---QKIETMQ-FEKDNLI 689 + L++ + +I L D+ + + +Q L E+ +K+E Q F K + Sbjct: 1186 PLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYIN 1245 Query: 690 TKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQE----V 745 ++ + ++ L+ +K ++ + +E LR E TL + + Sbjct: 1246 AIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFI 1305 Query: 746 QELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIF 805 E + E E+ +++ + +E+ A++EA L+ +++ E + +E + Sbjct: 1306 SETLRRMEEEERLAEQQRAEERERLAEVEAA---LEKQRQLAEAHAQAKAQAEREAK--- 1359 Query: 806 LDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQ 865 ++ + ++ V +E E D +QQ + EE+++ R + +E + ++ + Sbjct: 1360 --ELQQRMQEEVVRRE-----EAAVDAQQQKRSIQEELQQLRQS---SEAEIQAKARQAE 1409 Query: 866 EEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVA 925 L++++++ + + E + + A E LQ + + + A Sbjct: 1410 AAERSRLRIEEEIRVVRLQLEATERQRGGAEGE---LQALRARAEEAE-----------A 1455 Query: 926 ETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQ 985 + + E E+ ++ ++ + ++ ++EL+ R+ +E ++K + L E L+ Sbjct: 1456 QKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE----LRL 1511 Query: 986 EKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEE 1045 + E+ R R+ E+ RA VQ + R AE + SF E+ Sbjct: 1512 QAEEAERRLRQAEV----ERARQVQVA-----------LETAQRSAEAELQSKRASFAEK 1556 Query: 1046 SKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSE 1105 + + E S QE+ + + + +E+ RA Q +E ++ ++E +E Sbjct: 1557 TAQL-------------ERSLQEEHVA--VAQLREEAERRAQQQAEAERAREE-----AE 1596 Query: 1106 QNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIH 1165 + R Q++A + + V Q + + E +K +EE +E ++ Sbjct: 1597 RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQ-----------KEEAEREARRRG 1645 Query: 1166 QLELQTMKTQETGDEG--KPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVN 1223 + E Q ++ +E ++ K L G Q+ ++ E L+ E Sbjct: 1646 KAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELI--------------RLRAETE 1691 Query: 1224 AEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQ 1283 +++ + E E LQ ++ + L KV E LL SK + Sbjct: 1692 QGEQQRQ---LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLA-----SKARAE 1743 Query: 1284 QTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQEL 1343 + E ++ L E F + + L + K + + L + Q E Sbjct: 1744 EESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ----RQLAEEDAARQRAEA 1799 Query: 1344 ESLISSLQQQLKE-TEQNYEAEIHCLQK-----RLQAVSESTVPPSLPVDSVVIT-ESDA 1396 E +++ + E T EAEI +K RL+ ++E ++ ++D Sbjct: 1800 ERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI 1859 Query: 1397 QRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFA 1456 + + + ++K D +E + G+ E+T + + Q+EEE+ + S A A Sbjct: 1860 EERL---AQLRKASDSELE--RQKGLVEDT-------LRQRRQVEEEILALKASFEKAAA 1907 Query: 1457 QQTELS----RISGGKENTASSK---------QAHAVCQQEQHY------------FNEM 1491 + EL RI E+T SK Q ++E+ E Sbjct: 1908 GKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 1967 Query: 1492 KLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDI--PESKDCVLTIS 1549 Q + + E + K +E + + E +++ L+ E K + Sbjct: 1968 AARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQ 2027 Query: 1550 EEMFSKDKTFIVRQSIHDEISVSSMDASR--------QLMLNEEQLEDMRQ----ELVRQ 1597 ++ +T QS+ D++ + A R ++ E + RQ E ++Q Sbjct: 2028 QKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQ 2087 Query: 1598 YQEHQQATELLRQAHMRQMERQREDQ--EQLQEEIKRLNRQLAQRSSIDNENLVSE---R 1652 E Q QA ++ ++ E + + Q E L ++ A + ++ +E R Sbjct: 2088 SAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLR 2147 Query: 1653 ERVLLE-ELEALK-QLSLAGREK--LCCELRNSSTQTQNGNENQGEVEEQTFKEKELDRK 1708 ++ +E EL L+ QL +K L EL+ + + +VEE+ F + + Sbjct: 2148 QKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE 2207 Query: 1709 PEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSAS 1768 + I + R + + + + L E + V E R S +Q +A Sbjct: 2208 LSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAAR-------LSVAAQEAAR 2260 Query: 1769 LIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRS 1828 L +E + + + + E+ + +++ + + +++ ++ EL+Q R Sbjct: 2261 LRQLAEEDLAQQRALAEKMLKEKMQAVQEATR-------LKAEAELLQQQKELAQEQAR- 2312 Query: 1829 GFAGTEIDPENEELMLNISSRLQAAVEKLLEAIS----ETSSQLEHAKVTQTELMRESFR 1884 + + E++ ++ Q ++ LEA E S++ E K+ E+ R R Sbjct: 2313 -----RLQEDKEQMAQQLAEETQG-FQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQAR 2366 Query: 1885 QKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDI 1944 +++A K EE+ E+LH A ++ + E Q Q+ Sbjct: 2367 AEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT--------------LEIQRQQSDHD 2412 Query: 1945 IDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKE 2004 +RL + + ELE E++++Q+E +LL + E M+ ++QLLQET+ L + Sbjct: 2413 AERLREAIA-------ELEREKEKLQQEAKLLQLKSEEMQTVQ---QEQLLQETQALQQS 2462 Query: 2005 KLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEK 2064 L +D L ++ E +E++ ++ +L Q++ + LR++ Q ++Q+E+ Sbjct: 2463 FL-------SEKDSLLQR----ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2511 Query: 2065 MRKFL---DEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEK 2121 R+ L E+A R+HE + + Q+ QQL E Q R+ E+L L E+ Sbjct: 2512 ERQRLVASMEEARRRQHEAEEGVRRKQEELQQL----------EQQRRQQEEL---LAEE 2558 Query: 2122 TDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVEDRKHFGAVEAKPELSLEV 2181 + E L E+ R +EE+ + V + D A EA+PE S + Sbjct: 2559 NQRLREQLQLLEEQHRAALAHSEEVTASQ--VAATKTLPNGRDALDGPAAEAEPEHSFD- 2615 Query: 2182 QLQAERDAIDRKEKEITNLEE 2202 L+ + A +E I + EE Sbjct: 2616 GLRRKVSAQRLQEAGILSAEE 2636 Score = 139 bits (349), Expect = 7e-32 Identities = 361/1895 (19%), Positives = 769/1895 (40%), Gaps = 224/1895 (11%) Query: 424 QETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITV 483 QE +LE L ++ Q V MK L Q + + ++ +RS+S T Sbjct: 834 QEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQL-----------IRSWSLATF 882 Query: 484 NEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQ 543 + + A++ L + Q + + G E++ +R+ S +Q Sbjct: 883 RTLKPEEQRQALHSLELHYQAFLRDSQ---DAGGFGPEDRLMAEREYGSC----SHHYQQ 935 Query: 544 IQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEML 603 + ++ + A++ES+ + +S ++D++ ++ A E+R T ++++L + Sbjct: 936 LLQSLEQGAQEESR---CQRCISELKDIRLQL-EACETR-----------TVHRLRLPLD 980 Query: 604 EKEKNAVLDRMAESQ--EAELERLRTQL--LFSHEEELSKLKEDLEIEHRINIEKLKDNL 659 ++ R+AE Q +AE+E L + L + E++ L E + E L Sbjct: 981 KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSEL---EL 1037 Query: 660 GIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQ--------SLVN 711 + +Q+ L +K++T+ + L +LK+ Q Sbjct: 1038 TLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATK 1097 Query: 712 SKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFA 771 + +++ Q Q + LR E + + + +Q+ + ++ ++ +E+ L E++ Sbjct: 1098 ASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQ 1157 Query: 772 QLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEIL-IEENE 830 + A+ + + E + L L+ + S + +L + + +++I+ + + +++ Sbjct: 1158 AVLAQTDVRQRELEQLGRQLRYYRE-SADPLGAWLQDARRR------QEQIQAMPLADSQ 1210 Query: 831 DLKQQCIQ---LNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQEL 887 +++Q Q L EEIE+ ++ + +++ L+ K LE + + Sbjct: 1211 AVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAK- 1269 Query: 888 EYKSKLKALNEELHLQRINPTTVKMK-SSVFDEDKTFVAETLEMGEVVEKDTTELMEKLE 946 K K+++ +E + + ++ T + +++ + F++ETL E E+ L E+ Sbjct: 1270 --KPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER----LAEQQR 1323 Query: 947 VTKREKLELSQRLSDLSEQLKQKHGEISFLNE-EVKSLKQEKEQVSLRCRELEIIINHNR 1005 +RE+L + + QL + H + E E K L+Q ++ +R RE + + Sbjct: 1324 AEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR-REEAAVDAQQQ 1382 Query: 1006 AENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEES 1065 ++Q Q+ + + +R AE + E S++ +E+++ + + Sbjct: 1383 KRSIQEELQQLRQSSEAEIQAKARQAEAA---------ERSRLRIEEEIRVVRLQLEATE 1433 Query: 1066 KQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYS 1125 +Q L +LRA +E + QK ++E+ ++Q E+QR + V Sbjct: 1434 RQRGGAEGEL------QALRAR--AEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVEL 1485 Query: 1126 THVDQVREYMENEKDKALCSLKEELIFAQEEKIK----ELQKIHQLELQTMKTQETGDEG 1181 + EK +AL +L+E + A+E + + E+++ Q+++ Q + + Sbjct: 1486 ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE-- 1543 Query: 1182 KPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPE 1241 +LQ + Q S+ E+ A E + + E+ E Sbjct: 1544 -------AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAE 1596 Query: 1242 LQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEE 1301 + R++++ + L + + L + K ++ + + E+ + + E Sbjct: 1597 RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRE 1656 Query: 1302 TEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNY 1361 + Q E + +L++ Q+L + + E + E + + L+++L ++ Sbjct: 1657 LAEQELEKQRQLAEG---TAQQRLAAEQELIRLRAETEQGEQQRQL--LEEELARLQREA 1711 Query: 1362 EAEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFG 1421 A QKR + +E + + V+ S A+ S +K+ +G F Sbjct: 1712 AA---ATQKRQELEAELA---KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFR 1765 Query: 1422 -VKEETNIVKLL--EKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAH 1478 + EE ++ L E + Q QL EE A + A A++ +++ E T +A Sbjct: 1766 ELAEEAARLRALAEEAKRQRQLAEEDA----ARQRAEAERVLAEKLAAIGEATRLKTEAE 1821 Query: 1479 AVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDI 1538 ++++ ++ + FQ + L ++ +H DI Sbjct: 1822 IALKEKEAENERLRRLAEDEAFQR------------RRLEEQAAQHKA----------DI 1859 Query: 1539 PESKDCVLTISEEMFSKDKTFI---VRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELV 1595 E + S+ + K + +RQ E + ++ AS + + ++ + Sbjct: 1860 EERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRI 1919 Query: 1596 RQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERV 1655 R A + LR ++E R+ Q +EE +R + + S+ E + + + Sbjct: 1920 RS-----NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA 1974 Query: 1656 LLEELEALKQLSLAGREKLCCELRNSSTQTQNGNEN-----QGEVEEQTF----KEKELD 1706 LEE+E LK R + S+ Q Q E Q E + F KE+EL Sbjct: 1975 ALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQ 2034 Query: 1707 R--KPEDVPPEILSNE----RYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRS 1760 + + E + L E R A ++A ++ E ++ VEE L +S Sbjct: 2035 QTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER------LKQS 2088 Query: 1761 SKSQSSASLIWRSEAEASVKSCVHEEHTRVTDE--SIPSYSGSDMPRNDINMWSKVT-EE 1817 ++ Q+ A ++ AE K E R E ++ +D +++ T + Sbjct: 2089 AEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ 2148 Query: 1818 GTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTE 1877 ++ Q L E D + + L+ RL+A + S+ +L +V E Sbjct: 2149 KAQVEQELTTLRLQLEETDHQ-KNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE 2207 Query: 1878 LMRESFR-QKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFER 1936 L + R + + L+ ++ + L EE+ +Q+A E ++ A + L E Sbjct: 2208 LSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE 2267 Query: 1937 QIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQ 1996 + ++ + +++ +E + A L+AE + +Q+++EL Q ++ + + QQL + Sbjct: 2268 DLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAE 2327 Query: 1997 ETEKLMK-------EKLEVQCQAEKVR--------------DDLQKQVKALEIDVEEQVS 2035 ET+ + +LE+ +AE+++ +D Q+ K E ++ E++ Sbjct: 2328 ETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE-EIGEKLH 2386 Query: 2036 RFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLK 2095 R QEK T + L Q Q + E++R+ + E E E++ QQE + L QLK Sbjct: 2387 RTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAEL----EREKEKLQQEAKLL--QLK 2440 Query: 2096 VVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKE----QLQRDIQERNEEIEKL-- 2149 E QT + EQL ++T + LS++ Q +R I++ ++E+L Sbjct: 2441 S-------EEMQTVQQEQLL----QETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQ 2489 Query: 2150 -----EFRVRELEQALLVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQL 2204 ++RE +Q + + + A E + Q +AE + + RK++E+ LE+Q Sbjct: 2490 DEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAE-EGVRRKQEELQQLEQQR 2548 Query: 2205 EQFREELENKNEEVQQLHMQLEIQKKESTTRLQEL 2239 Q E L +N+ +++ LE Q + + +E+ Sbjct: 2549 RQQEELLAEENQRLREQLQLLEEQHRAALAHSEEV 2583 Score = 125 bits (315), Expect = 6e-28 Identities = 335/1644 (20%), Positives = 647/1644 (39%), Gaps = 231/1644 (14%) Query: 2109 REVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEF-RVRELEQALLVEDRKH 2167 RE ++H ++ + + + QR I E + +LE R + + L D++ Sbjct: 924 REYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEP 983 Query: 2168 FGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEI 2227 A E ++ + + QAE + + K + L + E+ L + L +LE+ Sbjct: 984 --ARECAQRIAEQQKAQAEVEGLG---KGVARLSAEAEKVLA-LPEPSPAAPTLRSELEL 1037 Query: 2228 QKKESTTRLQELEQENKLFKDDMEKLGLAIKESD-AMSTQDQHVLFGKFAQIIQEKEVEI 2286 + +L+++ + ++ + ++ + L I+ + A H K AQ + E+ Sbjct: 1038 ----TLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPEL 1093 Query: 2287 DQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNE 2346 + + KL+ Q + + + +R + E L R+ E+E+ E Sbjct: 1094 EATKASLKKLRAQAE--AQQPTFDALRDELRGAQEVGERLQQRHG----ERDVEVERWRE 1147 Query: 2347 VIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKL-ALEQQVETANEEMTFMK 2405 + +L + + +T + L + L++ + A+ L A Q E++ M Sbjct: 1148 RVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRES--ADPLGAWLQDARRRQEQIQAMP 1205 Query: 2406 NVLKETNFKMNQLTQE---LFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLT 2462 L ++ QL QE L ++R E VE+ Q + +N D+ EL++V Sbjct: 1206 --LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY------ELQLVTY 1257 Query: 2463 EDALKSLENQTYFKSFEENGKGSII----NLETRLLQLESTVSAKDLELTQCYKQIKDMQ 2518 + L+ + + K ++G S+I +L T +L + S +++ +++++ + Sbjct: 1258 KAQLEPVASPAK-KPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEE 1316 Query: 2519 EQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNI 2578 + Q++ +++ E V AAL Q QL AK +E E + Sbjct: 1317 RLAE------QQRAEERERLAE--VEAALEKQRQLAEAHAQAK-------AQAEREAKEL 1361 Query: 2579 QNLNQ---LREDELGSDISALTLRISELESQVVEMHTSLILEK-EQVEIAEKNVLEKEKK 2634 Q Q +R +E D I E Q+ + + I K Q E AE++ L E++ Sbjct: 1362 QQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEE 1421 Query: 2635 LLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATK 2694 + ++ LE E+++ G EL+ALRA + + Sbjct: 1422 IRVVRLQLEATERQR---------------------------GGAEGELQALRARAEEAE 1454 Query: 2695 AELASYKEKAEKLQEELLVKETNMTSLQKDL-SQVRDHLAEAKEKLSILEKEDETEVQES 2753 A+ +E+AE+L+ ++ + + +L S+V+ A+EK L+ +E +Q Sbjct: 1455 AQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAE 1514 Query: 2754 KKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGI-QINLQSECSSEEVTEI 2812 + ++ ++ Q L+ + + ++ K A + Q E S +E Sbjct: 1515 EAERRLRQAEVERAR----QVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVA 1570 Query: 2813 ISQFTEKIEKMQELHA-AEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLR 2871 ++Q E+ E+ + A AE E+ E LK + ++L EE K++ Q Sbjct: 1571 VAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEA 1630 Query: 2872 SKEGSSIPE------LAHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESE 2925 K+ A A + RE+ + +EG ++ Sbjct: 1631 EKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ-------------LAEGTAQQRL 1677 Query: 2926 SATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSI-----QQVSEPWLEERKAYI 2980 +A + LRA +G Q L E + + + +Q E L + +A + Sbjct: 1678 AAEQELIR-----LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEM 1732 Query: 2981 NTISSLK--------DLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSV 3032 + + K K + + EAE + E + R A +Q L E Sbjct: 1733 EVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDA 1792 Query: 3033 LLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQK-----ADRRSLLSEIQ 3087 E A+G L+ + E +A E L++ A +R L E Sbjct: 1793 ARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA 1852 Query: 3088 ALH-AQMNGRKITLKREQESEKPSQE-LLEYNIQQKQSQMLEMQVELSSMKDRATELQEQ 3145 A H A + R L++ +SE Q+ L+E ++Q++ +++ E+ ++K Sbjct: 1853 AQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRR----QVEEEILALK--------- 1899 Query: 3146 LSSEKMVV--AELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLA 3203 S EK AEL+ EL + + E TL++ K ELEA R A Sbjct: 1900 ASFEKAAAGKAELELELGRIRSNAEDTLRS--KEQAELEAARQR------------QLAA 1945 Query: 3204 SEQKKSRELQWALEKEKA---KLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQ 3260 E+++ RE + ++K A + R + EE+E LK +E ++ + +Q Q Sbjct: 1946 EEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQ 2005 Query: 3261 LLNESQQK---IESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDREREL--- 3314 L E+ QK E + + Q E+ ELQ L+ E+ + ++ + R Sbjct: 2006 LAQEAAQKRLQAEEKAHAFAVQQKEQ-----ELQQTLQQEQSVLDQLRGEAEAARRAAEE 2060 Query: 3315 --HAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIV----ELLNETEKYKLDSLQT 3368 A++Q+ QSR + + LK+ ++ + ++ +L E E+ Q Sbjct: 2061 AEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQA 2120 Query: 3369 RQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRL 3428 Q + +Q ++ ++ + ++ +++ ++ L+ QLEE Q LD E QRL Sbjct: 2121 EQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRL 2180 Query: 3429 QGIMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYA 3488 + E +Q + EE+ S R+ + L++ L+ +IE E + Sbjct: 2181 KAEATEAARQRSQVEEELFSVRVQMEELSK---------------LKARIEAENR----- 2220 Query: 3489 KLIEMNGGGTGCNHELEMIRQKLQCVASKLQVLPQKASERLQFETADDEDFIWVQENIDE 3548 LI + T L+ +K++ VA + L A E + +ED + Q + E Sbjct: 2221 ALILRDKDNT--QRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED-LAQQRALAE 2277 Query: 3549 IILQLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKL 3608 +L+ E+ V +T + E LL+Q EL ++ +E D M +L Sbjct: 2278 KMLK---------EKMQAVQEATRLKAEAE-LLQQQKELAQEQARRLQE--DKEQMAQQL 2325 Query: 3609 EEQIRWYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRAE--AEVY 3666 E+ + +++T L + +++E E + ++ RAE A+ + Sbjct: 2326 AEETQGFQRT-----------LEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRF 2374 Query: 3667 KLKAELRNDSLLQTLSPDSEHVTL 3690 + +AE + L +T E VTL Sbjct: 2375 RKQAEEIGEKLHRTELATQEKVTL 2398 Score = 48.5 bits (114), Expect = 1e-04 Identities = 142/683 (20%), Positives = 274/683 (40%), Gaps = 64/683 (9%) Query: 3052 LLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNG---RKITLKREQESEK 3108 LL LEQ QE+ C + +SE++ + Q+ R + R ++ Sbjct: 936 LLQSLEQGAQEES-------RC------QRCISELKDIRLQLEACETRTVHRLRLPLDKE 982 Query: 3109 PSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQT-KLEL 3167 P++E + +Q+++Q E+ + L + +EK++ S A T + EL Sbjct: 983 PARECAQRIAEQQKAQ-----AEVEGLGKGVARLSAE--AEKVLALPEPSPAAPTLRSEL 1035 Query: 3168 ETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSE 3227 E TL + + ++ L A LE K KT + + A E ++ E Q + Sbjct: 1036 ELTL-GKLEQVRSLSAIYLE-KLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPEL 1093 Query: 3228 ERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRN 3287 E K L+ L+ E+Q+ L L +++ QQ+ +R + + E + Sbjct: 1094 EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQR-HGERDVEVERWRERVAQL 1152 Query: 3288 LEL-QVLLESEKVRIREMSST---LDRERE----LHAQLQSSDGTGQSRPPLPSEDLLKE 3339 LE Q +L VR RE+ L RE L A LQ + + +P D + Sbjct: 1153 LERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADS-QA 1211 Query: 3340 LQKQLEEKHSRIVELLNETEKYKLDSLQTRQQME--KDRQVHRKTLQTEQEANTEGQKKM 3397 +++QL ++ + + E+ EK + +Q + KD ++ T + + E KK Sbjct: 1212 VREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKP 1271 Query: 3398 HELQSKVEDLQRQLEEKRQQVYKLD-LEGQRLQGIMQEFQKQELEREEKRESRRILYQNL 3456 ++QS E + ++ + R +L L Q ++ I + ++ E E + R + L Sbjct: 1272 -KVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERL 1330 Query: 3457 NEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMI--RQKLQCV 3514 E +L R + + + + + AK ++ E + +Q+ + + Sbjct: 1331 AEVEA-ALEKQRQ---LAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSI 1386 Query: 3515 ASKLQVLPQKASERLQFET----ADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSPS 3570 +LQ L Q + +Q + A + + ++E I + LQL+ Q+G + Sbjct: 1387 QEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL 1446 Query: 3571 TSCGSLTERLLRQNAELTGHIS-QLTEEKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRFS 3629 + E RQ E + Q+ +E R ++L +++ + A R+ Sbjct: 1447 RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVK--AEAEAAREKQRALQ 1504 Query: 3630 LNGGANIEAIIA------SEKEVWNREKLTLQKSLKRAEAEVYKLKAELRNDSLLQTLSP 3683 ++A A +E E + ++ L+ + + AEAE+ +A + S Sbjct: 1505 ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1564 Query: 3684 DSEHVTLKRIYGKYLRAESFRKA 3706 EHV + + LR E+ R+A Sbjct: 1565 QEEHVAVAQ-----LREEAERRA 1582 Score = 35.8 bits (81), Expect = 0.85 Identities = 52/235 (22%), Positives = 101/235 (42%), Gaps = 31/235 (13%) Query: 2138 DIQE--RNEEIEKLEFRVRELEQALLVEDRKHFGAVEAK--PELSLEVQLQAERDAIDRK 2193 D+Q+ R E++ REL LL R H A E + P E+++ + + K Sbjct: 235 DVQDGVRANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQ-FLKFK 293 Query: 2194 EKEITNLEEQLEQFREELENKNEEVQQLHMQ-------LEIQKKESTTRLQELEQENKLF 2246 E E+ E + + ++ VQ ++ L+++K+ + LE+E +L Sbjct: 294 EMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQL- 352 Query: 2247 KDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDN 2306 + + E+L Q ++ ++ E + +QLN+ LQ +++ Sbjct: 353 RSEFERLECL-----------QRIV----TKLQMEAGLCEEQLNQADALLQSDVRLLAAG 397 Query: 2307 KVIEEKNELIRDL---ETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANI 2358 KV + E+ RDL ++ I L +D + +K R + EQ+ + +L + L I Sbjct: 398 KVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAI 452 Score = 35.8 bits (81), Expect = 0.85 Identities = 60/292 (20%), Positives = 111/292 (38%), Gaps = 39/292 (13%) Query: 4 EERQKKLEAGKAKLAQFR-------QRKAQSDGQ-----SPSKKQKKKRKTSSSKHDVSA 51 +E+ ++L+ K ++AQ QR +++ Q S ++ K R S+ A Sbjct: 2308 QEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA 2367 Query: 52 HHDLNIDQSQCNEMYINSSQRVESTVIPESTIMRTLH-SGEITSHEQGFSVELESEISTT 110 D + Q E+ R E + T+++TL + + H+ E +E+ Sbjct: 2368 EEDAQRFRKQAEEIG-EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELERE 2426 Query: 111 ADDCSSEVNGCSFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHE 170 + E K L EE V Q Q + L ++ Sbjct: 2427 KEKLQQEA----------KLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERF 2476 Query: 171 IEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLE 230 IE+ +LE++ + Q +E + +Q + +L A++++ARR + E Sbjct: 2477 IEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRR 2536 Query: 231 LTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDH 282 E+ Q+L+ Q +Q + +LL + Q L Q QL E+ H Sbjct: 2537 KQEELQQLEQQRRQQE---------------ELLAEENQRLREQLQLLEEQH 2573 >gi|41322916 plectin 1 isoform 6 [Homo sapiens] Length = 4684 Score = 192 bits (487), Expect = 7e-48 Identities = 274/1260 (21%), Positives = 544/1260 (43%), Gaps = 171/1260 (13%) Query: 1579 QLMLNEEQLEDMRQE---LVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNR 1635 +++ EE D +Q+ + + Q+ +Q++E QA RQ E + +++EEI+ + Sbjct: 1537 EVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRL 1596 Query: 1636 QLA----QRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNEN 1691 QL QR + E + R EE EA K+ + E+L ++++ S Q + Sbjct: 1597 QLEATERQRGGAEGE---LQALRARAEEAEAQKRQAQEEAERLRRQVQDES---QRKRQA 1650 Query: 1692 QGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGR 1751 + E+ + E E R+ + + L R ++A RL + +E + ET Sbjct: 1651 EVELASRVKAEAEAAREKQRAL-QALEELRLQAEEAERRLRQAEVERARQVQVALETA-- 1707 Query: 1752 HVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMW 1811 RS++++ + +E A ++ + EEH V Sbjct: 1708 ------QRSAEAELQSKRASFAEKTAQLERSLQEEHVAV--------------------- 1740 Query: 1812 SKVTEEGTELSQRLVRSGFAGTEIDPENE--ELMLNISSRLQAAVEKLLEAISETSSQLE 1869 +++ EE +Q+ + A E + E E +L N + RL+ E++ + S ++ E Sbjct: 1741 AQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE 1800 Query: 1870 HAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYAD 1929 K E RE+ R+ + ++++ +E + L ++ + E A + AE + Sbjct: 1801 KQK---EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRA 1857 Query: 1930 EKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELL------------- 1976 E E+Q Q + + RL++E A+ + QELEAE +++ E E+L Sbjct: 1858 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS 1917 Query: 1977 --SRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQV 2034 + K+ ++AEAG ++L +E +L E + Q + +D +Q E + E++ Sbjct: 1918 TSEKSKQRLEAEAGRF-RELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKL 1976 Query: 2035 SRFIE---LEQEKNTELMDLRQQNQALEKQLEK---MRKFLDEQAIDREHERDVFQQEIQ 2088 + E L+ E L + +N+ L + E R+ L+EQA +H+ D+ ++ Q Sbjct: 1977 AAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA--AQHKADIEERLAQ 2034 Query: 2089 KLEQQLKVVPRFQPISE---HQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEE 2145 + + R + + E Q R+VE+ LK +K + K +L+ ++ Sbjct: 2035 LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAA---AGKAELELELGRIRSN 2091 Query: 2146 IEKLEFRVRELEQALLVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLE 2205 E +R EQA L R+ A E + + R+A +R +K + EE Sbjct: 2092 AED---TLRSKEQAELEAARQRQLAAEEE---------RRRREAEERVQKSLAAEEEAAR 2139 Query: 2206 QFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMST 2265 Q + L EEV++L ++E ++ QE ++ +L ++ +K A +++ A + Sbjct: 2140 QRKAAL----EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAV 2195 Query: 2266 QDQHVLFGKFAQIIQEKEVEIDQLNEQV------------TKLQQQLKITTDNKVIEEKN 2313 Q + + Q +Q+++ +DQL + ++Q + + + +EE Sbjct: 2196 QQKE---QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAE 2252 Query: 2314 ELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEA 2373 L + E Q + Q ++ R+E + E + Q E A + QK + +A E Sbjct: 2253 RLKQSAEEQAQARAQAQAAAEKLRKEAEQ---EAARRAQAEQAALRQKQAADA-----EM 2304 Query: 2374 DSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVE 2433 + K + + +K +EQ E+T ++ L+ET+ + N L +EL LK E Sbjct: 2305 EKHKKFAEQTLRQKAQVEQ-------ELTTLRLQLEETDHQKNLLDEELQRLKAEATEAA 2357 Query: 2434 KIQSIPEN---SVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLE 2490 + +S E SV V ++ LSK K +E L+ +N F EE K + E Sbjct: 2358 RQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQ-EEAEKMKQVAEE 2416 Query: 2491 TRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQ 2550 L + + +A+ +L + +D+ +Q +ML++K+ +Q+ K A L+ Q Sbjct: 2417 AARLSVAAQEAARLRQLAE-----EDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQ 2471 Query: 2551 IQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQL------REDELGSDISALTLRISEL- 2603 Q E QE A+ Q+++ ++ Q + R+ E+ ++ L LR++E+ Sbjct: 2472 -QKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMS 2530 Query: 2604 -----------------ESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNE 2646 E ++H + + +E+V + + +++++ + ++L E Sbjct: 2531 RAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIA 2590 Query: 2647 KKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAEL-------AS 2699 + +REKEK + Q+ ++L+ +E + ++ E +AL+ ++ K L Sbjct: 2591 ELEREKEKLQ--QEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQ 2648 Query: 2700 YKEKAEKLQEELLVKETNMTS----LQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKK 2755 K K E+L ++ + K + Q+ + Q R L + E+ + E E V+ ++ Sbjct: 2649 EKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQE 2708 Score = 171 bits (433), Expect = 1e-41 Identities = 345/1688 (20%), Positives = 693/1688 (41%), Gaps = 223/1688 (13%) Query: 1837 PENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQ 1896 PE + S L+ + KL + S ++ LE K + R Q A E L+ Sbjct: 1191 PEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVI-----RGTQGAEEVLRAH 1245 Query: 1897 EELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCAS 1956 EE + +E AV + E + +K + + Q+ T D L EL A Sbjct: 1246 EE---------QLKEAQAVPATLPELEATKASLKKLRAQAEAQQPT--FDALRDELRGA- 1293 Query: 1957 NRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVR 2016 QE+ QQ ER++ + A+ Q +L +T+ +E ++ Q R Sbjct: 1294 ---QEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYR 1350 Query: 2017 DDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDE-QAID 2075 + L+ D + + + + + + +Q QAL +++E+ + ++E Q Sbjct: 1351 ESADPLGAWLQ-DARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFA 1409 Query: 2076 REHERDVFQQEIQKL--EQQLKVV------PRFQPISEHQTREVEQLANHLKEKTDKCSE 2127 +++ + E+Q + + QL+ V P+ Q SE +E L H E T S+ Sbjct: 1410 KQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQ 1469 Query: 2128 LL--LSKEQLQRDIQERNEEIEKLEFRVRELEQALLVEDRKHFGAVEAKPELSLEVQLQA 2185 + +S+ + + +ER E ++ E R R E +E ++ A + + QA Sbjct: 1470 YIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHA------QAKAQA 1523 Query: 2186 ERDAID---RKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQE 2242 ER+A + R ++E+ EE +++ + EE+QQL E + + + + E+ Sbjct: 1524 EREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERS 1583 Query: 2243 NKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKI 2302 ++++ + L ++ ++ + L A+ +E E + Q E+ +L++Q Sbjct: 1584 RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARA-EEAEAQKRQAQEEAERLRRQ--- 1639 Query: 2303 TTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKT 2362 ++++++ R E ++ + + R ++ ++ L E+ +LQ Sbjct: 1640 ------VQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL--RLQ---------- 1681 Query: 2363 SMNAHSLSEEADSLKHQLDVVIAEKL--ALEQQVETANEEMTFMKNVLKETNFKMNQLTQ 2420 +EEA+ Q +V A ++ ALE +A E+ + E ++ + Sbjct: 1682 -------AEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLER--- 1731 Query: 2421 ELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEE 2480 SL+ E +V +++ E + + + E E L LK+ E Sbjct: 1732 ---SLQEEHVAVAQLREEAERRAQQQAE-AERAREEAERELERWQLKANEA--------- 1778 Query: 2481 NGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQ----GQFETEMLQKKIVNLQ 2536 L RL Q E K L + KQ ++ + + G+ E + ++++ + Q Sbjct: 1779 --------LRLRL-QAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1829 Query: 2537 KIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGS---DI 2593 ++ +++ A +Q +L A QE + + +E E+ Q QL E+EL + Sbjct: 1830 ELEKQRQLAEGTAQQRLAAEQELIR-------LRAETEQGEQQR--QLLEEELARLQREA 1880 Query: 2594 SALTLRISELESQVVEMHTS---LILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQR 2650 +A T + ELE+++ ++ L+ K + E ++ EK K+ LE E ++ Sbjct: 1881 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA----EAGRFREL 1936 Query: 2651 EKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALR--AESVATKAELASYKEKAEKLQ 2708 +E R E K +L EE EA R AE +A E K +AE Sbjct: 1937 AEEAARLRALAEEAKRQRQLA---EEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIAL 1993 Query: 2709 EELLVKETNMTSLQKDLS--------QVRDHLAEAKEKLSILEKEDETEVQESK------ 2754 +E + + L +D + Q H A+ +E+L+ L K ++E++ K Sbjct: 1994 KEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDT 2053 Query: 2755 ----KACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVT 2810 + E L +K S A+ L++ I+ N + S+E Sbjct: 2054 LRQRRQVEEEILALKASFEKAAAGKAELELELGR-----------IRSNAEDTLRSKEQA 2102 Query: 2811 EIISQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCL 2870 E+ + ++ +E E + + ++ E R+ A+ EE LKA ++ Sbjct: 2103 ELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL----EEVERLKAKVEEA 2158 Query: 2871 R------SKEGSSIPELAHSDAY---QTREICSSDSGSDWGQGIYLTHSQGFDIASEGRG 2921 R +E + +LA A Q E + + Q + T Q + + RG Sbjct: 2159 RRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRG 2218 Query: 2922 EESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYIN 2981 E +E+A + A E +V + E+ S + +++ + E+ +A Sbjct: 2219 E-AEAARRA----------AEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQ 2267 Query: 2982 TISSLKDLITKMQLQ--REAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRT 3039 ++ + L + + + R A+ ++ + +D E + L +++ + T Sbjct: 2268 AQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTT 2327 Query: 3040 ELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADR-----RSLLSEIQALHAQMN 3094 L TD N L++ +Q E A + + R + E+ L A++ Sbjct: 2328 LRLQLEETDHQK--NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIE 2385 Query: 3095 G--RKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATEL---------Q 3143 R + L+ + +++ QE E K Q+ E LS A L Q Sbjct: 2386 AENRALILRDKDNTQRFLQEEAE-----KMKQVAEEAARLSVAAQEAARLRQLAEEDLAQ 2440 Query: 3144 EQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLA 3203 ++ +EKM+ ++++ T+L+ E L Q K L + +A RL+ + L +T Sbjct: 2441 QRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQG 2500 Query: 3204 S----EQKKSRELQWALEKEKAKL-----GRSEERDKEELEDLKFSLESQKQRNLQLNLL 3254 E ++ R+L+ + E E+ KL R++ R +E+ + + E ++ L L Sbjct: 2501 FQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEK-LHRTEL 2559 Query: 3255 LEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDREREL 3314 Q+K L ++ + I+ Q+ +DA+ E LE + ++ ++ ++ S + + Sbjct: 2560 ATQEKVTLVQTLE-IQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQ 2618 Query: 3315 HAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNE----TEKYKLDSLQTRQ 3370 LQ + QS L +D L + ++ +E++ +++ +L + ++ + + + +Q Sbjct: 2619 EQLLQETQALQQSF--LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQ 2676 Query: 3371 QMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQG 3430 QME++RQ + + + +EA + ++ K E+LQ+ +++RQQ L E QRL+ Sbjct: 2677 QMEQERQ---RLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLRE 2733 Query: 3431 IMQEFQKQ 3438 +Q ++Q Sbjct: 2734 QLQLLEEQ 2741 Score = 158 bits (399), Expect = 1e-37 Identities = 323/1676 (19%), Positives = 685/1676 (40%), Gaps = 242/1676 (14%) Query: 153 SPTHLEMMESELAGKQHEIEELNR-ELEEMR----VTYGTEGLQQ-LQEFEAAIKQRDGI 206 +PT +E L GK ++ L+ LE+++ V GT+G ++ L+ E +K+ + Sbjct: 1197 APTLRSELELTL-GKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAV 1255 Query: 207 ITQLT------ANLQQARREKDETMREFLELTEQ---SQKLQIQFQQLQASETLRNSTHS 257 L A+L++ R + + F L ++ +Q++ + QQ + Sbjct: 1256 PATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWR 1315 Query: 258 STAADLLQAKQQILTH----QQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQD 313 A LL+ Q +L Q++LE+ L Y++ + ++LQ+ + E Q Sbjct: 1316 ERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLG---AWLQDARRRQEQIQA 1372 Query: 314 KKVENSN--KEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQ 371 + +S +E++++++ ++EE+ +K E + + + + Q+V Sbjct: 1373 MPLADSQAVREQLRQEQALLEEIE----RHGEKVEECQRFAKQYINAIKDYELQLVTYKA 1428 Query: 372 EIKNMKLELTNSKQKERQSS--EEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRK 429 +++ + K + S +E L EL + +F ++ ++RME+E +R Sbjct: 1429 QLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEE-ERL 1487 Query: 430 LEQLRAE-----------------LDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEME 472 EQ RAE L E + Q Q ++E EE+ R + ++ Sbjct: 1488 AEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVD 1547 Query: 473 NALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKE---KLKEELGLI---LE----- 521 + S + E+ +L + E+ K + + + +++EE+ ++ LE Sbjct: 1548 AQQQKRS---IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQ 1604 Query: 522 ------EKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEI 575 E AL+ + E+ + ++E+ +R R+ + ++ + +A L++ +KAE Sbjct: 1605 RGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELAS--RVKAEA 1662 Query: 576 VSASESRKEL----ELKHEAEVTNYKIKLEMLEKEK--NAVLDRMAESQEAELERLRTQL 629 +A E ++ L EL+ +AE +++ +E+ + L+ S EAEL+ R Sbjct: 1663 EAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRA-- 1720 Query: 630 LFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDG--LQNEMSQKIETMQFEKDN 687 S E+ ++L+ L+ EH + + +L++ +QQ + + E +++E Q + + Sbjct: 1721 --SFAEKTAQLERSLQEEH-VAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANE 1777 Query: 688 LITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTL-EQEVQ 746 + + Q E+++ K L Q+ E +K+ E +E + +G EQ V+ Sbjct: 1778 ALRLRLQ-AEEVAQQKSLAQA--------------EAEKQKEEAEREARRRGKAEEQAVR 1822 Query: 747 ELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFL 806 + +L + LEKQ + E Q++ A AE +++ L+ T +++R + Sbjct: 1823 QRELAEQELEKQRQLAEGTAQQRLA---AEQELIR---------LRAETEQGEQQRQLLE 1870 Query: 807 DSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEI-----------EKQRNTFSFAEK 855 + + + ++E ++ ++L+ + ++ E+ E+ R+T +++ Sbjct: 1871 EEL------ARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQ 1924 Query: 856 NFEV---NYQELQEEYACLLKVKDD-------LEDSKNKQELEYK----SKLKALNEELH 901 E ++EL EE A L + ++ E+ +Q E + KL A+ E Sbjct: 1925 RLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATR 1984 Query: 902 LQRINPTTVKMKSSVFD------EDKTFVAETLEMGEVVEKDTTELMEKL-EVTKREKLE 954 L+ +K K + + ED+ F LE E + ++ E+L ++ K E Sbjct: 1985 LKTEAEIALKEKEAENERLRRLAEDEAFQRRRLE--EQAAQHKADIEERLAQLRKASDSE 2042 Query: 955 LSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDT 1014 L ++ + + L+Q+ + EE+ +LK E+ + ELE+ + R+ + + Sbjct: 2043 LERQKGLVEDTLRQRRQ----VEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS 2098 Query: 1015 QVSSLLDG-----VVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQ 1069 + + L+ + R + +V KS E + + K + E + + +E Sbjct: 2099 KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 2158 Query: 1070 LILDHLPSVTKESSLRATQPSENDKLQKE--LNVLKSEQNDLRLQMEAQRICLSLVYSTH 1127 L L+ Q + +LQ E + +Q + LQ Q+ + Sbjct: 2159 RRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ------EQSV 2212 Query: 1128 VDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLL 1187 +DQ+R E + +A +E + A+ E + +++ + E +E Sbjct: 2213 LDQLRGEAEAAR-RAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAA 2271 Query: 1188 IGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRY 1247 KL+K +E + Q + L + + E + + E Q R Sbjct: 2272 AEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE--------------QTLRQ 2317 Query: 1248 EVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSI 1307 + Q QE + TL ++ E ++ +L L ++ + T+ + + E E S+ Sbjct: 2318 KAQVEQE-LTTLRLQLEETDHQKNLLDEELQRLKAEATEAAR------QRSQVEEELFSV 2370 Query: 1308 HSQMTNLEDID--VNHKSKLSSLQDLEKTK--LEEQVQELESL------ISSLQQQLKET 1357 QM L + + +++ L+D + T+ L+E+ ++++ + +S Q+ Sbjct: 2371 RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARL 2430 Query: 1358 EQNYEAEI--------HCLQKRLQAVSEST---VPPSLPVDSVVITESDAQRTMYPGSCV 1406 Q E ++ L++++QAV E+T L + + A+R + Sbjct: 2431 RQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM 2490 Query: 1407 KKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISG 1466 + + +E + LE + Q QLE + + +A E+SR Sbjct: 2491 AQQL-----------AEETQGFQRTLEAERQRQLEMSAEAERLKLRVA-----EMSRAQA 2534 Query: 1467 GKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGK 1526 E A + A E+ + E+ + QT E + + + L + + E + Sbjct: 2535 RAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELER 2594 Query: 1527 EILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQ 1586 E + + + + T+ +E ++ T ++QS E S + R + + + Sbjct: 2595 EKEKLQQEAKLLQLKSEEMQTVQQEQLLQE-TQALQQSFLSE-KDSLLQRERFIEQEKAK 2652 Query: 1587 LEDM-------RQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQ 1639 LE + Q+L + Q QQ E RQ + ME R Q + +E ++R +L Q Sbjct: 2653 LEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQ 2712 Query: 1640 --RSSIDNENLVSERERVLLEELEALKQ---LSLAGREKLCCELRNSSTQTQNGNE 1690 + E L++E + L E+L+ L++ +LA E++ ++ NG + Sbjct: 2713 LEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRD 2768 Score = 151 bits (382), Expect = 1e-35 Identities = 318/1657 (19%), Positives = 679/1657 (40%), Gaps = 234/1657 (14%) Query: 1992 QQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDL 2051 QQLLQ E+ +E+ Q +++D ++ Q++A E ++ + L++E E Sbjct: 1103 QQLLQSLEQGAQEESRCQRCISELKD-IRLQLEACETRTVHRLR--LPLDKEPARECAQR 1159 Query: 2052 RQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREV 2111 + Q + ++E + K + + + E ++ L + P + E ++ Sbjct: 1160 IAEQQKAQAEVEGLGKGVARLSAEAE--------KVLALPEPSPAAPTLRSELELTLGKL 1211 Query: 2112 EQLANHLKEKTDKCSELLL------SKEQLQRDIQERNEEIEKLEFRVRELEQALLVEDR 2165 EQ+ + +K + L E++ R +E+ +E + + + ELE + Sbjct: 1212 EQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKK 1271 Query: 2166 KHFGAVEAKPEL-SLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQ 2224 A +P +L +L+ ++ +R ++ + ++E++RE + E Q + Q Sbjct: 1272 LRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQ 1331 Query: 2225 LEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEV 2284 +++++E L++L ++ + +++ + LG ++++ Q Q + +Q ++E+ Sbjct: 1332 TDVRQRE----LEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLAD-SQAVREQLR 1386 Query: 2285 EIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRN-REEEIEQ 2343 + L E++ + + K+ + ++ I+D E Q+ + E V ++ +++ Sbjct: 1387 QEQALLEEIERHGE--KVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQS 1444 Query: 2344 LNE-VIEKLQQELANIGQKTSMNAHSLS---------EEADSLKHQLDVVIAEKLA---- 2389 +E VI++ + + T++ + + EE + L Q E+LA Sbjct: 1445 GSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEA 1504 Query: 2390 -LEQQVETANEEMTFMKNVLKETNFKMNQLTQELF--------SLKRERESVEKIQSIPE 2440 LE+Q + A +E ++ +E+ + +++R E++Q + + Sbjct: 1505 ALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQ 1564 Query: 2441 NS-VNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENG-KGSIINLETRLLQLES 2498 +S + + E + E+ ++ + Q + G +G + L R + E+ Sbjct: 1565 SSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEA 1624 Query: 2499 TVSAKDLELTQCYKQIKD-MQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQ 2557 E + +Q++D Q + Q E E+ + + E++ A + +++L+A + Sbjct: 1625 QKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQA-E 1683 Query: 2558 EYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILE 2617 E + + + + + ++ + E EL S ++ + ++LE + E H ++ Sbjct: 1684 EAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQL 1743 Query: 2618 KEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREK----------EKKRSPQDVEVLKTT 2667 +E+ E + E E+ E ++ LE + K E +++S E K Sbjct: 1744 REEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK 1803 Query: 2668 TELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQ 2727 E G E +A+R +A + EL ++ AE ++ L E + L+ + Q Sbjct: 1804 EEAEREARRRGKAEE-QAVRQRELAEQ-ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQ 1861 Query: 2728 VRDHLAEAKEKLSILEKEDETEVQ-----ESKKACMFEPLPIKLSKSIASQTDGTLKISS 2782 +E+L+ L++E Q E++ A + + + L+ ++ + S+ Sbjct: 1862 GEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR---ST 1918 Query: 2783 SNQTPQILVKNAGIQINLQSECSS----EEVTEIISQFTEKIEKMQELHAAEILDMESRH 2838 S ++ Q L AG L E + E + Q E+ Q A +L + Sbjct: 1919 SEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAA 1978 Query: 2839 ISETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREI------ 2892 I E LK E +A LKE + E + LA +A+Q R + Sbjct: 1979 IGEATRLKTEAEIA---LKE------------KEAENERLRRLAEDEAFQRRRLEEQAAQ 2023 Query: 2893 -------------CSSDSGSDWGQGIY--------------LTHSQGFDIASEGRGEES- 2924 +SDS + +G+ L F+ A+ G+ E Sbjct: 2024 HKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELEL 2083 Query: 2925 ------ESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVS--EPWLEER 2976 +A D+ K + L A Q+ + E + E+ + ++ E +R Sbjct: 2084 ELGRIRSNAEDTLRSKEQAELEAARQR--QLAAEEERRRREAEERVQKSLAAEEEAARQR 2141 Query: 2977 KAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLA--------------- 3021 KA + + LK + + + RE +S++ + + + L A Sbjct: 2142 KAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQE 2201 Query: 3022 LQQVFLEERSVL------------------LAAFRTELTALGTTDAVGLLNCLEQRIQEQ 3063 LQQ +E+SVL A + E A + V L+Q +EQ Sbjct: 2202 LQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQ 2261 Query: 3064 G---VEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQ 3120 + QAA E L+K + QA A + ++ ++ +K +++ L Q Sbjct: 2262 AQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQV 2321 Query: 3121 KQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKE 3180 +Q ++ ++++L + L E+L K E + +Q + EL +++ Q + L + Sbjct: 2322 EQ-ELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEEL-FSVRVQMEELSK 2379 Query: 3181 LEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEK---------EKAKLGRSEERDK 3231 L+A R+E +++ + ++T Q+++ +++ E+ E A+L + E D Sbjct: 2380 LKA-RIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDL 2438 Query: 3232 EELEDLKFSLESQKQRNLQLNL-------LLEQQKQLLNESQQKIESQRMLYDAQLSEE- 3283 + L + +K + +Q LL+QQK+L E ++++ + QL+EE Sbjct: 2439 AQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEET 2498 Query: 3284 QG----------RNLELQVLLESEKVRIREMSSTLDR-ERELHAQLQSSDGTGQS--RPP 3330 QG R LE+ E K+R+ EMS R E + + ++ G+ R Sbjct: 2499 QGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTE 2558 Query: 3331 LPSEDLLK-----ELQKQ-----LEEKHSRIVELLNETEKY---------KLDSLQTRQQ 3371 L +++ + E+Q+Q E I EL E EK K + +QT QQ Sbjct: 2559 LATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQ 2618 Query: 3372 ME--KDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDL--------QRQLEEKRQQVYKL 3421 + ++ Q +++ +E+++ + ++ + + ++K+E L Q+ EE+++Q ++ Sbjct: 2619 EQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQM 2678 Query: 3422 DLEGQRLQGIMQEFQKQELEREEKRESRRILYQNLNE 3458 + E QRL M+E ++++ E EE ++ Q L + Sbjct: 2679 EQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQ 2715 Score = 147 bits (370), Expect = 3e-34 Identities = 322/1585 (20%), Positives = 651/1585 (41%), Gaps = 255/1585 (16%) Query: 1858 LEAISETSSQLEHAKVTQTELMRESFRQKQEATESLK--------CQEELRERLHEESRA 1909 L+ Q++ + ++ +RE RQ+Q E ++ CQ ++ ++ Sbjct: 1360 LQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY 1419 Query: 1910 REQLAVELSK----------------AEGVIDGYADEKT-------LFERQIQEKTDIID 1946 QL ++ +E VI Y D +T L + I+ ++ + Sbjct: 1420 ELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLR 1479 Query: 1947 RLEQELLCASN-------RLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETE 1999 R+E+E A RL E+EA ++ ++ E ++ K + EA ++Q++ +E Sbjct: 1480 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1539 Query: 2000 KLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEK---NTELMDLRQQNQ 2056 + + ++ Q Q ++++LQ+ ++ E +++ + + E+ + E+ +R Q + Sbjct: 1540 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE 1599 Query: 2057 ALEKQ---LEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQ 2113 A E+Q E + L +A + E ++ Q+E ++L +Q+ Q S+ + + + Sbjct: 1600 ATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQV------QDESQRKRQAEVE 1653 Query: 2114 LANHLKEKTDKCSE---LLLSKEQLQRDIQERNEEIEKLEF-RVRELEQALLVEDRKHFG 2169 LA+ +K + + E L + E+L+ +E + + E R R+++ AL R Sbjct: 1654 LASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA 1713 Query: 2170 AVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLE---QFREELENKNEEVQQLHMQLE 2226 +++K E Q ER ++ + + L E+ E Q + E E EE ++ + + Sbjct: 1714 ELQSKRASFAEKTAQLER-SLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ 1772 Query: 2227 IQKKESTT-RLQ--ELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKE 2283 ++ E+ RLQ E+ Q+ L + + EK KE + + GK +E+ Sbjct: 1773 LKANEALRLRLQAEEVAQQKSLAQAEAEKQ----KEEAEREARRR----GK----AEEQA 1820 Query: 2284 VEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQ 2343 V +L EQ + Q+QL T + + + ELIR L ++ E E++ + Sbjct: 1821 VRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR--------LRAETE----QGEQQRQL 1868 Query: 2344 LNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTF 2403 L E + +LQ+E A QK L E ++ +++V++A K E++ + +E+ Sbjct: 1869 LEEELARLQREAAAATQKRQ----ELEAELAKVRAEMEVLLASKARAEEESRSTSEKS-- 1922 Query: 2404 MKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVN--------------VAIDH 2449 K L+ + +L +E L+ E ++ + + E AI Sbjct: 1923 -KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGE 1981 Query: 2450 LSKDKPELEVVLTE-----DALKSLENQTYF--KSFEENGKGSIINLETRLLQLESTVSA 2502 ++ K E E+ L E + L+ L F + EE ++E RL QL A Sbjct: 1982 ATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRK---A 2038 Query: 2503 KDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKF 2562 D EL + ++D Q + ++++I+ L+ E+ A +++L ++ A+ Sbjct: 2039 SDSELERQKGLVEDTLRQRR----QVEEEILALKASFEKAAAGKAELELELGRIRSNAE- 2093 Query: 2563 CQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVE 2622 T+ S+ + L R+ +L ++ R E E +V + SL E+E Sbjct: 2094 ----DTLRSKEQA----ELEAARQRQLAAEEER---RRREAEERVQK---SLAAEEEAAR 2139 Query: 2623 IAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNE 2682 K LE+ ++L K ++ RE+ ++ S + +++ + + Sbjct: 2140 -QRKAALEEVERL----KAKVEEARRLRERAEQESARQLQLAQEAAQ------------- 2181 Query: 2683 LEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSIL 2742 + L+AE KA + ++K ++LQ+ L +++ + L+ + R EA+E Sbjct: 2182 -KRLQAEE---KAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQA 2237 Query: 2743 EKE---DETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQIN 2799 E+E +V+E+++ + + + K + + + A ++ Sbjct: 2238 EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK 2297 Query: 2800 LQSECSSEEVTEIISQ-FTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLLKE 2858 ++ E+ + Q +K + QEL + + ET+ K LL E Sbjct: 2298 QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRL------QLEETDHQKN-------LLDE 2344 Query: 2859 ECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIASE 2918 E LKA +++ S + E S Q E+ + I +E Sbjct: 2345 ELQRLKAEAT-EAARQRSQVEEELFSVRVQMEELSKLKAR----------------IEAE 2387 Query: 2919 GRGE--ESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEER 2976 R + T F ++ ++ V E ++ + E ++Q++E L ++ Sbjct: 2388 NRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQ------EAARLRQLAEEDLAQQ 2441 Query: 2977 KAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAA 3036 +A K L KMQ +EA + LL Q+ +E++ L Sbjct: 2442 RALAE-----KMLKEKMQAVQEATRLKAEAE-----------LLQQQKELAQEQARRLQE 2485 Query: 3037 FRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGR 3096 + ++ + G LE Q Q +E A E L+ R + +S QA A+ + + Sbjct: 2486 DKEQMAQQLAEETQGFQRTLEAERQRQ-LEMSAEAERLKL--RVAEMSRAQA-RAEEDAQ 2541 Query: 3097 KITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAEL 3156 + + E+ EK + E Q+K + + ++++ A L+E +AEL Sbjct: 2542 RFRKQAEEIGEKLHRT--ELATQEKVTLVQTLEIQRQQSDHDAERLRE-------AIAEL 2592 Query: 3157 KSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWAL 3216 + E + KL+ E L LK E ++ + E L + SE+ + + + Sbjct: 2593 ERE--KEKLQQEAKLL----QLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFI 2646 Query: 3217 EKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLY 3276 E+EKAKL + + + + + L+ + Q+Q+ +EQ++Q L S + E++R + Sbjct: 2647 EQEKAKLEQLFQDEVAKAQQLREEQQRQQQQ-------MEQERQRLVASME--EARRRQH 2697 Query: 3277 DAQ----LSEEQGRNLELQ-----VLLESEKVRIREMSSTLDRERE---LHAQLQSSDGT 3324 +A+ +E+ + LE Q LL E R+RE L+ + H++ ++ Sbjct: 2698 EAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQV 2757 Query: 3325 GQSRPPLPSEDLLKELQKQLEEKHS 3349 ++ D L + E +HS Sbjct: 2758 AATKTLPNGRDALDGPAAEAEPEHS 2782 Score = 141 bits (356), Expect = 1e-32 Identities = 365/1881 (19%), Positives = 749/1881 (39%), Gaps = 298/1881 (15%) Query: 417 DIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALR 476 DI ++E R + +LR LD+ ++ Q + Q AQ E+E + Sbjct: 1128 DIRLQLEACETRTVHRLRLPLDKEPARECAQ---RIAEQQKAQ---------AEVEGLGK 1175 Query: 477 SYSNITVNEDQIKLM---NVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQ---RQL 530 + ++ +++ + + A L +L+ T + E+++ + LE+ + R Sbjct: 1176 GVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGT 1235 Query: 531 EDLVEELSFSREQIQRARQ---TIAEQES------KLN-EAHKSLSTVEDLKAEIVSASE 580 + E L EQ++ A+ T+ E E+ KL +A T + L+ E+ A E Sbjct: 1236 QGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQE 1295 Query: 581 SRKELELKH---EAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEEL 637 + L+ +H + EV ++ ++ L + AVL + + ++ ELE+L QL + E Sbjct: 1296 VGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQ-TDVRQRELEQLGRQLRYYRESAD 1354 Query: 638 ---SKLKEDLEIEHRINIEKLKDNLGIHYK-QQIDGLQNEMS---QKIETMQ-FEKDNLI 689 + L++ + +I L D+ + + +Q L E+ +K+E Q F K + Sbjct: 1355 PLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYIN 1414 Query: 690 TKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQE----V 745 ++ + ++ L+ +K ++ + +E LR E TL + + Sbjct: 1415 AIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFI 1474 Query: 746 QELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIF 805 E + E E+ +++ + +E+ A++EA L+ +++ E + +E + Sbjct: 1475 SETLRRMEEEERLAEQQRAEERERLAEVEAA---LEKQRQLAEAHAQAKAQAEREAK--- 1528 Query: 806 LDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQ 865 ++ + ++ V +E E D +QQ + EE+++ R + +E + ++ + Sbjct: 1529 --ELQQRMQEEVVRRE-----EAAVDAQQQKRSIQEELQQLRQS---SEAEIQAKARQAE 1578 Query: 866 EEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVA 925 L++++++ + + E + + A E LQ + + + A Sbjct: 1579 AAERSRLRIEEEIRVVRLQLEATERQRGGAEGE---LQALRARAEEAE-----------A 1624 Query: 926 ETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQ 985 + + E E+ ++ ++ + ++ ++EL+ R+ +E ++K + L E L+ Sbjct: 1625 QKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE----LRL 1680 Query: 986 EKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEE 1045 + E+ R R+ E+ RA VQ + R AE + SF E+ Sbjct: 1681 QAEEAERRLRQAEV----ERARQVQVA-----------LETAQRSAEAELQSKRASFAEK 1725 Query: 1046 SKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSE 1105 + + E S QE+ + + + +E+ RA Q +E ++ ++E +E Sbjct: 1726 TAQL-------------ERSLQEEHVA--VAQLREEAERRAQQQAEAERAREE-----AE 1765 Query: 1106 QNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIH 1165 + R Q++A + + V Q + + E +K +EE +E ++ Sbjct: 1766 RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQ-----------KEEAEREARRRG 1814 Query: 1166 QLELQTMKTQETGDEG--KPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVN 1223 + E Q ++ +E ++ K L G Q+ ++ E L+ E Sbjct: 1815 KAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELI--------------RLRAETE 1860 Query: 1224 AEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQ 1283 +++ + E E LQ ++ + L KV E LL SK + Sbjct: 1861 QGEQQRQ---LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLA-----SKARAE 1912 Query: 1284 QTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQEL 1343 + E ++ L E F + + L + K + + L + Q E Sbjct: 1913 EESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ----RQLAEEDAARQRAEA 1968 Query: 1344 ESLISSLQQQLKE-TEQNYEAEIHCLQK-----RLQAVSESTVPPSLPVDSVVIT-ESDA 1396 E +++ + E T EAEI +K RL+ ++E ++ ++D Sbjct: 1969 ERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI 2028 Query: 1397 QRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFA 1456 + + + ++K D +E + G+ E+T + + Q+EEE+ + S A A Sbjct: 2029 EERL---AQLRKASDSELE--RQKGLVEDT-------LRQRRQVEEEILALKASFEKAAA 2076 Query: 1457 QQTELS----RISGGKENTASSK---------QAHAVCQQEQHY------------FNEM 1491 + EL RI E+T SK Q ++E+ E Sbjct: 2077 GKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 2136 Query: 1492 KLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDI--PESKDCVLTIS 1549 Q + + E + K +E + + E +++ L+ E K + Sbjct: 2137 AARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQ 2196 Query: 1550 EEMFSKDKTFIVRQSIHDEISVSSMDASR--------QLMLNEEQLEDMRQ----ELVRQ 1597 ++ +T QS+ D++ + A R ++ E + RQ E ++Q Sbjct: 2197 QKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQ 2256 Query: 1598 YQEHQQATELLRQAHMRQMERQREDQ--EQLQEEIKRLNRQLAQRSSIDNENLVSE---R 1652 E Q QA ++ ++ E + + Q E L ++ A + ++ +E R Sbjct: 2257 SAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLR 2316 Query: 1653 ERVLLE-ELEALK-QLSLAGREK--LCCELRNSSTQTQNGNENQGEVEEQTFKEKELDRK 1708 ++ +E EL L+ QL +K L EL+ + + +VEE+ F + + Sbjct: 2317 QKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE 2376 Query: 1709 PEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSAS 1768 + I + R + + + + L E + V E R S +Q +A Sbjct: 2377 LSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAAR-------LSVAAQEAAR 2429 Query: 1769 LIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRS 1828 L +E + + + + E+ + +++ + + +++ ++ EL+Q R Sbjct: 2430 LRQLAEEDLAQQRALAEKMLKEKMQAVQEATR-------LKAEAELLQQQKELAQEQAR- 2481 Query: 1829 GFAGTEIDPENEELMLNISSRLQAAVEKLLEAIS----ETSSQLEHAKVTQTELMRESFR 1884 + + E++ ++ Q ++ LEA E S++ E K+ E+ R R Sbjct: 2482 -----RLQEDKEQMAQQLAEETQG-FQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQAR 2535 Query: 1885 QKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDI 1944 +++A K EE+ E+LH A ++ + E Q Q+ Sbjct: 2536 AEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT--------------LEIQRQQSDHD 2581 Query: 1945 IDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKE 2004 +RL + + ELE E++++Q+E +LL + E M+ ++QLLQET+ L + Sbjct: 2582 AERLREAIA-------ELEREKEKLQQEAKLLQLKSEEMQTVQ---QEQLLQETQALQQS 2631 Query: 2005 KLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEK 2064 L +D L ++ E +E++ ++ +L Q++ + LR++ Q ++Q+E+ Sbjct: 2632 FL-------SEKDSLLQR----ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2680 Query: 2065 MRKFL---DEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEK 2121 R+ L E+A R+HE + + Q+ QQL E Q R+ E+L L E+ Sbjct: 2681 ERQRLVASMEEARRRQHEAEEGVRRKQEELQQL----------EQQRRQQEEL---LAEE 2727 Query: 2122 TDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVEDRKHFGAVEAKPELSLEV 2181 + E L E+ R +EE+ + V + D A EA+PE S + Sbjct: 2728 NQRLREQLQLLEEQHRAALAHSEEVTASQ--VAATKTLPNGRDALDGPAAEAEPEHSFD- 2784 Query: 2182 QLQAERDAIDRKEKEITNLEE 2202 L+ + A +E I + EE Sbjct: 2785 GLRRKVSAQRLQEAGILSAEE 2805 Score = 139 bits (349), Expect = 7e-32 Identities = 361/1895 (19%), Positives = 769/1895 (40%), Gaps = 224/1895 (11%) Query: 424 QETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITV 483 QE +LE L ++ Q V MK L Q + + ++ +RS+S T Sbjct: 1003 QEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQL-----------IRSWSLATF 1051 Query: 484 NEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQ 543 + + A++ L + Q + + G E++ +R+ S +Q Sbjct: 1052 RTLKPEEQRQALHSLELHYQAFLRDSQ---DAGGFGPEDRLMAEREYGSC----SHHYQQ 1104 Query: 544 IQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEML 603 + ++ + A++ES+ + +S ++D++ ++ A E+R T ++++L + Sbjct: 1105 LLQSLEQGAQEESR---CQRCISELKDIRLQL-EACETR-----------TVHRLRLPLD 1149 Query: 604 EKEKNAVLDRMAESQ--EAELERLRTQL--LFSHEEELSKLKEDLEIEHRINIEKLKDNL 659 ++ R+AE Q +AE+E L + L + E++ L E + E L Sbjct: 1150 KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSEL---EL 1206 Query: 660 GIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQ--------SLVN 711 + +Q+ L +K++T+ + L +LK+ Q Sbjct: 1207 TLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATK 1266 Query: 712 SKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFA 771 + +++ Q Q + LR E + + + +Q+ + ++ ++ +E+ L E++ Sbjct: 1267 ASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQ 1326 Query: 772 QLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEIL-IEENE 830 + A+ + + E + L L+ + S + +L + + +++I+ + + +++ Sbjct: 1327 AVLAQTDVRQRELEQLGRQLRYYRE-SADPLGAWLQDARRR------QEQIQAMPLADSQ 1379 Query: 831 DLKQQCIQ---LNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQEL 887 +++Q Q L EEIE+ ++ + +++ L+ K LE + + Sbjct: 1380 AVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAK- 1438 Query: 888 EYKSKLKALNEELHLQRINPTTVKMK-SSVFDEDKTFVAETLEMGEVVEKDTTELMEKLE 946 K K+++ +E + + ++ T + +++ + F++ETL E E+ L E+ Sbjct: 1439 --KPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER----LAEQQR 1492 Query: 947 VTKREKLELSQRLSDLSEQLKQKHGEISFLNE-EVKSLKQEKEQVSLRCRELEIIINHNR 1005 +RE+L + + QL + H + E E K L+Q ++ +R RE + + Sbjct: 1493 AEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR-REEAAVDAQQQ 1551 Query: 1006 AENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEES 1065 ++Q Q+ + + +R AE + E S++ +E+++ + + Sbjct: 1552 KRSIQEELQQLRQSSEAEIQAKARQAEAA---------ERSRLRIEEEIRVVRLQLEATE 1602 Query: 1066 KQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYS 1125 +Q L +LRA +E + QK ++E+ ++Q E+QR + V Sbjct: 1603 RQRGGAEGEL------QALRAR--AEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVEL 1654 Query: 1126 THVDQVREYMENEKDKALCSLKEELIFAQEEKIK----ELQKIHQLELQTMKTQETGDEG 1181 + EK +AL +L+E + A+E + + E+++ Q+++ Q + + Sbjct: 1655 ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE-- 1712 Query: 1182 KPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPE 1241 +LQ + Q S+ E+ A E + + E+ E Sbjct: 1713 -------AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAE 1765 Query: 1242 LQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEE 1301 + R++++ + L + + L + K ++ + + E+ + + E Sbjct: 1766 RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRE 1825 Query: 1302 TEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNY 1361 + Q E + +L++ Q+L + + E + E + + L+++L ++ Sbjct: 1826 LAEQELEKQRQLAEG---TAQQRLAAEQELIRLRAETEQGEQQRQL--LEEELARLQREA 1880 Query: 1362 EAEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFG 1421 A QKR + +E + + V+ S A+ S +K+ +G F Sbjct: 1881 AA---ATQKRQELEAELA---KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFR 1934 Query: 1422 -VKEETNIVKLL--EKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAH 1478 + EE ++ L E + Q QL EE A + A A++ +++ E T +A Sbjct: 1935 ELAEEAARLRALAEEAKRQRQLAEEDA----ARQRAEAERVLAEKLAAIGEATRLKTEAE 1990 Query: 1479 AVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDI 1538 ++++ ++ + FQ + L ++ +H DI Sbjct: 1991 IALKEKEAENERLRRLAEDEAFQR------------RRLEEQAAQHKA----------DI 2028 Query: 1539 PESKDCVLTISEEMFSKDKTFI---VRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELV 1595 E + S+ + K + +RQ E + ++ AS + + ++ + Sbjct: 2029 EERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRI 2088 Query: 1596 RQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERV 1655 R A + LR ++E R+ Q +EE +R + + S+ E + + + Sbjct: 2089 RS-----NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA 2143 Query: 1656 LLEELEALKQLSLAGREKLCCELRNSSTQTQNGNEN-----QGEVEEQTF----KEKELD 1706 LEE+E LK R + S+ Q Q E Q E + F KE+EL Sbjct: 2144 ALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQ 2203 Query: 1707 R--KPEDVPPEILSNE----RYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRS 1760 + + E + L E R A ++A ++ E ++ VEE L +S Sbjct: 2204 QTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER------LKQS 2257 Query: 1761 SKSQSSASLIWRSEAEASVKSCVHEEHTRVTDE--SIPSYSGSDMPRNDINMWSKVT-EE 1817 ++ Q+ A ++ AE K E R E ++ +D +++ T + Sbjct: 2258 AEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ 2317 Query: 1818 GTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTE 1877 ++ Q L E D + + L+ RL+A + S+ +L +V E Sbjct: 2318 KAQVEQELTTLRLQLEETDHQ-KNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE 2376 Query: 1878 LMRESFR-QKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFER 1936 L + R + + L+ ++ + L EE+ +Q+A E ++ A + L E Sbjct: 2377 LSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE 2436 Query: 1937 QIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQ 1996 + ++ + +++ +E + A L+AE + +Q+++EL Q ++ + + QQL + Sbjct: 2437 DLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAE 2496 Query: 1997 ETEKLMK-------EKLEVQCQAEKVR--------------DDLQKQVKALEIDVEEQVS 2035 ET+ + +LE+ +AE+++ +D Q+ K E ++ E++ Sbjct: 2497 ETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE-EIGEKLH 2555 Query: 2036 RFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLK 2095 R QEK T + L Q Q + E++R+ + E E E++ QQE + L QLK Sbjct: 2556 RTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAEL----EREKEKLQQEAKLL--QLK 2609 Query: 2096 VVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKE----QLQRDIQERNEEIEKL-- 2149 E QT + EQL ++T + LS++ Q +R I++ ++E+L Sbjct: 2610 S-------EEMQTVQQEQLL----QETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQ 2658 Query: 2150 -----EFRVRELEQALLVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQL 2204 ++RE +Q + + + A E + Q +AE + + RK++E+ LE+Q Sbjct: 2659 DEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAE-EGVRRKQEELQQLEQQR 2717 Query: 2205 EQFREELENKNEEVQQLHMQLEIQKKESTTRLQEL 2239 Q E L +N+ +++ LE Q + + +E+ Sbjct: 2718 RQQEELLAEENQRLREQLQLLEEQHRAALAHSEEV 2752 Score = 125 bits (315), Expect = 6e-28 Identities = 335/1644 (20%), Positives = 647/1644 (39%), Gaps = 231/1644 (14%) Query: 2109 REVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEF-RVRELEQALLVEDRKH 2167 RE ++H ++ + + + QR I E + +LE R + + L D++ Sbjct: 1093 REYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEP 1152 Query: 2168 FGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEI 2227 A E ++ + + QAE + + K + L + E+ L + L +LE+ Sbjct: 1153 --ARECAQRIAEQQKAQAEVEGLG---KGVARLSAEAEKVLA-LPEPSPAAPTLRSELEL 1206 Query: 2228 QKKESTTRLQELEQENKLFKDDMEKLGLAIKESD-AMSTQDQHVLFGKFAQIIQEKEVEI 2286 + +L+++ + ++ + ++ + L I+ + A H K AQ + E+ Sbjct: 1207 ----TLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPEL 1262 Query: 2287 DQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNE 2346 + + KL+ Q + + + +R + E L R+ E+E+ E Sbjct: 1263 EATKASLKKLRAQAE--AQQPTFDALRDELRGAQEVGERLQQRHG----ERDVEVERWRE 1316 Query: 2347 VIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKL-ALEQQVETANEEMTFMK 2405 + +L + + +T + L + L++ + A+ L A Q E++ M Sbjct: 1317 RVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRES--ADPLGAWLQDARRRQEQIQAMP 1374 Query: 2406 NVLKETNFKMNQLTQE---LFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLT 2462 L ++ QL QE L ++R E VE+ Q + +N D+ EL++V Sbjct: 1375 --LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY------ELQLVTY 1426 Query: 2463 EDALKSLENQTYFKSFEENGKGSII----NLETRLLQLESTVSAKDLELTQCYKQIKDMQ 2518 + L+ + + K ++G S+I +L T +L + S +++ +++++ + Sbjct: 1427 KAQLEPVASPAK-KPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEE 1485 Query: 2519 EQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNI 2578 + Q++ +++ E V AAL Q QL AK +E E + Sbjct: 1486 RLAE------QQRAEERERLAE--VEAALEKQRQLAEAHAQAK-------AQAEREAKEL 1530 Query: 2579 QNLNQ---LREDELGSDISALTLRISELESQVVEMHTSLILEK-EQVEIAEKNVLEKEKK 2634 Q Q +R +E D I E Q+ + + I K Q E AE++ L E++ Sbjct: 1531 QQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEE 1590 Query: 2635 LLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATK 2694 + ++ LE E+++ G EL+ALRA + + Sbjct: 1591 IRVVRLQLEATERQR---------------------------GGAEGELQALRARAEEAE 1623 Query: 2695 AELASYKEKAEKLQEELLVKETNMTSLQKDL-SQVRDHLAEAKEKLSILEKEDETEVQES 2753 A+ +E+AE+L+ ++ + + +L S+V+ A+EK L+ +E +Q Sbjct: 1624 AQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAE 1683 Query: 2754 KKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGI-QINLQSECSSEEVTEI 2812 + ++ ++ Q L+ + + ++ K A + Q E S +E Sbjct: 1684 EAERRLRQAEVERAR----QVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVA 1739 Query: 2813 ISQFTEKIEKMQELHA-AEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLR 2871 ++Q E+ E+ + A AE E+ E LK + ++L EE K++ Q Sbjct: 1740 VAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEA 1799 Query: 2872 SKEGSSIPE------LAHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESE 2925 K+ A A + RE+ + +EG ++ Sbjct: 1800 EKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ-------------LAEGTAQQRL 1846 Query: 2926 SATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSI-----QQVSEPWLEERKAYI 2980 +A + LRA +G Q L E + + + +Q E L + +A + Sbjct: 1847 AAEQELIR-----LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEM 1901 Query: 2981 NTISSLK--------DLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSV 3032 + + K K + + EAE + E + R A +Q L E Sbjct: 1902 EVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDA 1961 Query: 3033 LLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQK-----ADRRSLLSEIQ 3087 E A+G L+ + E +A E L++ A +R L E Sbjct: 1962 ARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA 2021 Query: 3088 ALH-AQMNGRKITLKREQESEKPSQE-LLEYNIQQKQSQMLEMQVELSSMKDRATELQEQ 3145 A H A + R L++ +SE Q+ L+E ++Q++ +++ E+ ++K Sbjct: 2022 AQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRR----QVEEEILALK--------- 2068 Query: 3146 LSSEKMVV--AELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLA 3203 S EK AEL+ EL + + E TL++ K ELEA R A Sbjct: 2069 ASFEKAAAGKAELELELGRIRSNAEDTLRS--KEQAELEAARQR------------QLAA 2114 Query: 3204 SEQKKSRELQWALEKEKA---KLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQ 3260 E+++ RE + ++K A + R + EE+E LK +E ++ + +Q Q Sbjct: 2115 EEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQ 2174 Query: 3261 LLNESQQK---IESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDREREL--- 3314 L E+ QK E + + Q E+ ELQ L+ E+ + ++ + R Sbjct: 2175 LAQEAAQKRLQAEEKAHAFAVQQKEQ-----ELQQTLQQEQSVLDQLRGEAEAARRAAEE 2229 Query: 3315 --HAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIV----ELLNETEKYKLDSLQT 3368 A++Q+ QSR + + LK+ ++ + ++ +L E E+ Q Sbjct: 2230 AEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQA 2289 Query: 3369 RQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRL 3428 Q + +Q ++ ++ + ++ +++ ++ L+ QLEE Q LD E QRL Sbjct: 2290 EQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRL 2349 Query: 3429 QGIMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYA 3488 + E +Q + EE+ S R+ + L++ L+ +IE E + Sbjct: 2350 KAEATEAARQRSQVEEELFSVRVQMEELSK---------------LKARIEAENR----- 2389 Query: 3489 KLIEMNGGGTGCNHELEMIRQKLQCVASKLQVLPQKASERLQFETADDEDFIWVQENIDE 3548 LI + T L+ +K++ VA + L A E + +ED + Q + E Sbjct: 2390 ALILRDKDNT--QRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED-LAQQRALAE 2446 Query: 3549 IILQLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKL 3608 +L+ E+ V +T + E LL+Q EL ++ +E D M +L Sbjct: 2447 KMLK---------EKMQAVQEATRLKAEAE-LLQQQKELAQEQARRLQE--DKEQMAQQL 2494 Query: 3609 EEQIRWYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRAE--AEVY 3666 E+ + +++T L + +++E E + ++ RAE A+ + Sbjct: 2495 AEETQGFQRT-----------LEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRF 2543 Query: 3667 KLKAELRNDSLLQTLSPDSEHVTL 3690 + +AE + L +T E VTL Sbjct: 2544 RKQAEEIGEKLHRTELATQEKVTL 2567 Score = 48.5 bits (114), Expect = 1e-04 Identities = 142/683 (20%), Positives = 274/683 (40%), Gaps = 64/683 (9%) Query: 3052 LLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNG---RKITLKREQESEK 3108 LL LEQ QE+ C + +SE++ + Q+ R + R ++ Sbjct: 1105 LLQSLEQGAQEES-------RC------QRCISELKDIRLQLEACETRTVHRLRLPLDKE 1151 Query: 3109 PSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQT-KLEL 3167 P++E + +Q+++Q E+ + L + +EK++ S A T + EL Sbjct: 1152 PARECAQRIAEQQKAQ-----AEVEGLGKGVARLSAE--AEKVLALPEPSPAAPTLRSEL 1204 Query: 3168 ETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSE 3227 E TL + + ++ L A LE K KT + + A E ++ E Q + Sbjct: 1205 ELTL-GKLEQVRSLSAIYLE-KLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPEL 1262 Query: 3228 ERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRN 3287 E K L+ L+ E+Q+ L L +++ QQ+ +R + + E + Sbjct: 1263 EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQR-HGERDVEVERWRERVAQL 1321 Query: 3288 LEL-QVLLESEKVRIREMSST---LDRERE----LHAQLQSSDGTGQSRPPLPSEDLLKE 3339 LE Q +L VR RE+ L RE L A LQ + + +P D + Sbjct: 1322 LERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADS-QA 1380 Query: 3340 LQKQLEEKHSRIVELLNETEKYKLDSLQTRQQME--KDRQVHRKTLQTEQEANTEGQKKM 3397 +++QL ++ + + E+ EK + +Q + KD ++ T + + E KK Sbjct: 1381 VREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKP 1440 Query: 3398 HELQSKVEDLQRQLEEKRQQVYKLD-LEGQRLQGIMQEFQKQELEREEKRESRRILYQNL 3456 ++QS E + ++ + R +L L Q ++ I + ++ E E + R + L Sbjct: 1441 -KVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERL 1499 Query: 3457 NEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMI--RQKLQCV 3514 E +L R + + + + + AK ++ E + +Q+ + + Sbjct: 1500 AEVEA-ALEKQRQ---LAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSI 1555 Query: 3515 ASKLQVLPQKASERLQFET----ADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSPS 3570 +LQ L Q + +Q + A + + ++E I + LQL+ Q+G + Sbjct: 1556 QEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL 1615 Query: 3571 TSCGSLTERLLRQNAELTGHIS-QLTEEKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRFS 3629 + E RQ E + Q+ +E R ++L +++ + A R+ Sbjct: 1616 RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVK--AEAEAAREKQRALQ 1673 Query: 3630 LNGGANIEAIIA------SEKEVWNREKLTLQKSLKRAEAEVYKLKAELRNDSLLQTLSP 3683 ++A A +E E + ++ L+ + + AEAE+ +A + S Sbjct: 1674 ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1733 Query: 3684 DSEHVTLKRIYGKYLRAESFRKA 3706 EHV + + LR E+ R+A Sbjct: 1734 QEEHVAVAQ-----LREEAERRA 1751 Score = 35.8 bits (81), Expect = 0.85 Identities = 52/235 (22%), Positives = 101/235 (42%), Gaps = 31/235 (13%) Query: 2138 DIQE--RNEEIEKLEFRVRELEQALLVEDRKHFGAVEAK--PELSLEVQLQAERDAIDRK 2193 D+Q+ R E++ REL LL R H A E + P E+++ + + K Sbjct: 404 DVQDGVRANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQ-FLKFK 462 Query: 2194 EKEITNLEEQLEQFREELENKNEEVQQLHMQ-------LEIQKKESTTRLQELEQENKLF 2246 E E+ E + + ++ VQ ++ L+++K+ + LE+E +L Sbjct: 463 EMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQL- 521 Query: 2247 KDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDN 2306 + + E+L Q ++ ++ E + +QLN+ LQ +++ Sbjct: 522 RSEFERLECL-----------QRIV----TKLQMEAGLCEEQLNQADALLQSDVRLLAAG 566 Query: 2307 KVIEEKNELIRDL---ETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANI 2358 KV + E+ RDL ++ I L +D + +K R + EQ+ + +L + L I Sbjct: 567 KVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAI 621 Score = 35.8 bits (81), Expect = 0.85 Identities = 60/292 (20%), Positives = 111/292 (38%), Gaps = 39/292 (13%) Query: 4 EERQKKLEAGKAKLAQFR-------QRKAQSDGQ-----SPSKKQKKKRKTSSSKHDVSA 51 +E+ ++L+ K ++AQ QR +++ Q S ++ K R S+ A Sbjct: 2477 QEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA 2536 Query: 52 HHDLNIDQSQCNEMYINSSQRVESTVIPESTIMRTLH-SGEITSHEQGFSVELESEISTT 110 D + Q E+ R E + T+++TL + + H+ E +E+ Sbjct: 2537 EEDAQRFRKQAEEIG-EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELERE 2595 Query: 111 ADDCSSEVNGCSFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHE 170 + E K L EE V Q Q + L ++ Sbjct: 2596 KEKLQQEA----------KLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERF 2645 Query: 171 IEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLE 230 IE+ +LE++ + Q +E + +Q + +L A++++ARR + E Sbjct: 2646 IEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRR 2705 Query: 231 LTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDH 282 E+ Q+L+ Q +Q + +LL + Q L Q QL E+ H Sbjct: 2706 KQEELQQLEQQRRQQE---------------ELLAEENQRLREQLQLLEEQH 2742 >gi|41322908 plectin 1 isoform 3 [Homo sapiens] Length = 4525 Score = 192 bits (487), Expect = 7e-48 Identities = 274/1260 (21%), Positives = 544/1260 (43%), Gaps = 171/1260 (13%) Query: 1579 QLMLNEEQLEDMRQE---LVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNR 1635 +++ EE D +Q+ + + Q+ +Q++E QA RQ E + +++EEI+ + Sbjct: 1378 EVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRL 1437 Query: 1636 QLA----QRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNEN 1691 QL QR + E + R EE EA K+ + E+L ++++ S Q + Sbjct: 1438 QLEATERQRGGAEGE---LQALRARAEEAEAQKRQAQEEAERLRRQVQDES---QRKRQA 1491 Query: 1692 QGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGR 1751 + E+ + E E R+ + + L R ++A RL + +E + ET Sbjct: 1492 EVELASRVKAEAEAAREKQRAL-QALEELRLQAEEAERRLRQAEVERARQVQVALETA-- 1548 Query: 1752 HVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMW 1811 RS++++ + +E A ++ + EEH V Sbjct: 1549 ------QRSAEAELQSKRASFAEKTAQLERSLQEEHVAV--------------------- 1581 Query: 1812 SKVTEEGTELSQRLVRSGFAGTEIDPENE--ELMLNISSRLQAAVEKLLEAISETSSQLE 1869 +++ EE +Q+ + A E + E E +L N + RL+ E++ + S ++ E Sbjct: 1582 AQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE 1641 Query: 1870 HAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYAD 1929 K E RE+ R+ + ++++ +E + L ++ + E A + AE + Sbjct: 1642 KQK---EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRA 1698 Query: 1930 EKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELL------------- 1976 E E+Q Q + + RL++E A+ + QELEAE +++ E E+L Sbjct: 1699 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS 1758 Query: 1977 --SRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQV 2034 + K+ ++AEAG ++L +E +L E + Q + +D +Q E + E++ Sbjct: 1759 TSEKSKQRLEAEAGRF-RELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKL 1817 Query: 2035 SRFIE---LEQEKNTELMDLRQQNQALEKQLEK---MRKFLDEQAIDREHERDVFQQEIQ 2088 + E L+ E L + +N+ L + E R+ L+EQA +H+ D+ ++ Q Sbjct: 1818 AAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA--AQHKADIEERLAQ 1875 Query: 2089 KLEQQLKVVPRFQPISE---HQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEE 2145 + + R + + E Q R+VE+ LK +K + K +L+ ++ Sbjct: 1876 LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAA---AGKAELELELGRIRSN 1932 Query: 2146 IEKLEFRVRELEQALLVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLE 2205 E +R EQA L R+ A E + + R+A +R +K + EE Sbjct: 1933 AED---TLRSKEQAELEAARQRQLAAEEE---------RRRREAEERVQKSLAAEEEAAR 1980 Query: 2206 QFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMST 2265 Q + L EEV++L ++E ++ QE ++ +L ++ +K A +++ A + Sbjct: 1981 QRKAAL----EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAV 2036 Query: 2266 QDQHVLFGKFAQIIQEKEVEIDQLNEQV------------TKLQQQLKITTDNKVIEEKN 2313 Q + + Q +Q+++ +DQL + ++Q + + + +EE Sbjct: 2037 QQKE---QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAE 2093 Query: 2314 ELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEA 2373 L + E Q + Q ++ R+E + E + Q E A + QK + +A E Sbjct: 2094 RLKQSAEEQAQARAQAQAAAEKLRKEAEQ---EAARRAQAEQAALRQKQAADA-----EM 2145 Query: 2374 DSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVE 2433 + K + + +K +EQ E+T ++ L+ET+ + N L +EL LK E Sbjct: 2146 EKHKKFAEQTLRQKAQVEQ-------ELTTLRLQLEETDHQKNLLDEELQRLKAEATEAA 2198 Query: 2434 KIQSIPEN---SVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLE 2490 + +S E SV V ++ LSK K +E L+ +N F EE K + E Sbjct: 2199 RQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQ-EEAEKMKQVAEE 2257 Query: 2491 TRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQ 2550 L + + +A+ +L + +D+ +Q +ML++K+ +Q+ K A L+ Q Sbjct: 2258 AARLSVAAQEAARLRQLAE-----EDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQ 2312 Query: 2551 IQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQL------REDELGSDISALTLRISEL- 2603 Q E QE A+ Q+++ ++ Q + R+ E+ ++ L LR++E+ Sbjct: 2313 -QKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMS 2371 Query: 2604 -----------------ESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNE 2646 E ++H + + +E+V + + +++++ + ++L E Sbjct: 2372 RAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIA 2431 Query: 2647 KKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAEL-------AS 2699 + +REKEK + Q+ ++L+ +E + ++ E +AL+ ++ K L Sbjct: 2432 ELEREKEKLQ--QEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQ 2489 Query: 2700 YKEKAEKLQEELLVKETNMTS----LQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKK 2755 K K E+L ++ + K + Q+ + Q R L + E+ + E E V+ ++ Sbjct: 2490 EKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQE 2549 Score = 171 bits (433), Expect = 1e-41 Identities = 345/1688 (20%), Positives = 693/1688 (41%), Gaps = 223/1688 (13%) Query: 1837 PENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQ 1896 PE + S L+ + KL + S ++ LE K + R Q A E L+ Sbjct: 1032 PEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVI-----RGTQGAEEVLRAH 1086 Query: 1897 EELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCAS 1956 EE + +E AV + E + +K + + Q+ T D L EL A Sbjct: 1087 EE---------QLKEAQAVPATLPELEATKASLKKLRAQAEAQQPT--FDALRDELRGA- 1134 Query: 1957 NRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVR 2016 QE+ QQ ER++ + A+ Q +L +T+ +E ++ Q R Sbjct: 1135 ---QEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYR 1191 Query: 2017 DDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDE-QAID 2075 + L+ D + + + + + + +Q QAL +++E+ + ++E Q Sbjct: 1192 ESADPLGAWLQ-DARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFA 1250 Query: 2076 REHERDVFQQEIQKL--EQQLKVV------PRFQPISEHQTREVEQLANHLKEKTDKCSE 2127 +++ + E+Q + + QL+ V P+ Q SE +E L H E T S+ Sbjct: 1251 KQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQ 1310 Query: 2128 LL--LSKEQLQRDIQERNEEIEKLEFRVRELEQALLVEDRKHFGAVEAKPELSLEVQLQA 2185 + +S+ + + +ER E ++ E R R E +E ++ A + + QA Sbjct: 1311 YIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHA------QAKAQA 1364 Query: 2186 ERDAID---RKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQE 2242 ER+A + R ++E+ EE +++ + EE+QQL E + + + + E+ Sbjct: 1365 EREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERS 1424 Query: 2243 NKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKI 2302 ++++ + L ++ ++ + L A+ +E E + Q E+ +L++Q Sbjct: 1425 RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARA-EEAEAQKRQAQEEAERLRRQ--- 1480 Query: 2303 TTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKT 2362 ++++++ R E ++ + + R ++ ++ L E+ +LQ Sbjct: 1481 ------VQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL--RLQ---------- 1522 Query: 2363 SMNAHSLSEEADSLKHQLDVVIAEKL--ALEQQVETANEEMTFMKNVLKETNFKMNQLTQ 2420 +EEA+ Q +V A ++ ALE +A E+ + E ++ + Sbjct: 1523 -------AEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLER--- 1572 Query: 2421 ELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEE 2480 SL+ E +V +++ E + + + E E L LK+ E Sbjct: 1573 ---SLQEEHVAVAQLREEAERRAQQQAE-AERAREEAERELERWQLKANEA--------- 1619 Query: 2481 NGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQ----GQFETEMLQKKIVNLQ 2536 L RL Q E K L + KQ ++ + + G+ E + ++++ + Q Sbjct: 1620 --------LRLRL-QAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1670 Query: 2537 KIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGS---DI 2593 ++ +++ A +Q +L A QE + + +E E+ Q QL E+EL + Sbjct: 1671 ELEKQRQLAEGTAQQRLAAEQELIR-------LRAETEQGEQQR--QLLEEELARLQREA 1721 Query: 2594 SALTLRISELESQVVEMHTS---LILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQR 2650 +A T + ELE+++ ++ L+ K + E ++ EK K+ LE E ++ Sbjct: 1722 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA----EAGRFREL 1777 Query: 2651 EKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALR--AESVATKAELASYKEKAEKLQ 2708 +E R E K +L EE EA R AE +A E K +AE Sbjct: 1778 AEEAARLRALAEEAKRQRQLA---EEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIAL 1834 Query: 2709 EELLVKETNMTSLQKDLS--------QVRDHLAEAKEKLSILEKEDETEVQESK------ 2754 +E + + L +D + Q H A+ +E+L+ L K ++E++ K Sbjct: 1835 KEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDT 1894 Query: 2755 ----KACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVT 2810 + E L +K S A+ L++ I+ N + S+E Sbjct: 1895 LRQRRQVEEEILALKASFEKAAAGKAELELELGR-----------IRSNAEDTLRSKEQA 1943 Query: 2811 EIISQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCL 2870 E+ + ++ +E E + + ++ E R+ A+ EE LKA ++ Sbjct: 1944 ELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL----EEVERLKAKVEEA 1999 Query: 2871 R------SKEGSSIPELAHSDAY---QTREICSSDSGSDWGQGIYLTHSQGFDIASEGRG 2921 R +E + +LA A Q E + + Q + T Q + + RG Sbjct: 2000 RRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRG 2059 Query: 2922 EESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYIN 2981 E +E+A + A E +V + E+ S + +++ + E+ +A Sbjct: 2060 E-AEAARRA----------AEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQ 2108 Query: 2982 TISSLKDLITKMQLQ--REAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRT 3039 ++ + L + + + R A+ ++ + +D E + L +++ + T Sbjct: 2109 AQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTT 2168 Query: 3040 ELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADR-----RSLLSEIQALHAQMN 3094 L TD N L++ +Q E A + + R + E+ L A++ Sbjct: 2169 LRLQLEETDHQK--NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIE 2226 Query: 3095 G--RKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATEL---------Q 3143 R + L+ + +++ QE E K Q+ E LS A L Q Sbjct: 2227 AENRALILRDKDNTQRFLQEEAE-----KMKQVAEEAARLSVAAQEAARLRQLAEEDLAQ 2281 Query: 3144 EQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLA 3203 ++ +EKM+ ++++ T+L+ E L Q K L + +A RL+ + L +T Sbjct: 2282 QRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQG 2341 Query: 3204 S----EQKKSRELQWALEKEKAKL-----GRSEERDKEELEDLKFSLESQKQRNLQLNLL 3254 E ++ R+L+ + E E+ KL R++ R +E+ + + E ++ L L Sbjct: 2342 FQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEK-LHRTEL 2400 Query: 3255 LEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDREREL 3314 Q+K L ++ + I+ Q+ +DA+ E LE + ++ ++ ++ S + + Sbjct: 2401 ATQEKVTLVQTLE-IQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQ 2459 Query: 3315 HAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNE----TEKYKLDSLQTRQ 3370 LQ + QS L +D L + ++ +E++ +++ +L + ++ + + + +Q Sbjct: 2460 EQLLQETQALQQSF--LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQ 2517 Query: 3371 QMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQG 3430 QME++RQ + + + +EA + ++ K E+LQ+ +++RQQ L E QRL+ Sbjct: 2518 QMEQERQ---RLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLRE 2574 Query: 3431 IMQEFQKQ 3438 +Q ++Q Sbjct: 2575 QLQLLEEQ 2582 Score = 158 bits (399), Expect = 1e-37 Identities = 323/1676 (19%), Positives = 685/1676 (40%), Gaps = 242/1676 (14%) Query: 153 SPTHLEMMESELAGKQHEIEELNR-ELEEMR----VTYGTEGLQQ-LQEFEAAIKQRDGI 206 +PT +E L GK ++ L+ LE+++ V GT+G ++ L+ E +K+ + Sbjct: 1038 APTLRSELELTL-GKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAV 1096 Query: 207 ITQLT------ANLQQARREKDETMREFLELTEQ---SQKLQIQFQQLQASETLRNSTHS 257 L A+L++ R + + F L ++ +Q++ + QQ + Sbjct: 1097 PATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWR 1156 Query: 258 STAADLLQAKQQILTH----QQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQD 313 A LL+ Q +L Q++LE+ L Y++ + ++LQ+ + E Q Sbjct: 1157 ERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLG---AWLQDARRRQEQIQA 1213 Query: 314 KKVENSN--KEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQ 371 + +S +E++++++ ++EE+ +K E + + + + Q+V Sbjct: 1214 MPLADSQAVREQLRQEQALLEEIE----RHGEKVEECQRFAKQYINAIKDYELQLVTYKA 1269 Query: 372 EIKNMKLELTNSKQKERQSS--EEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRK 429 +++ + K + S +E L EL + +F ++ ++RME+E +R Sbjct: 1270 QLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEE-ERL 1328 Query: 430 LEQLRAE-----------------LDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEME 472 EQ RAE L E + Q Q ++E EE+ R + ++ Sbjct: 1329 AEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVD 1388 Query: 473 NALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKE---KLKEELGLI---LE----- 521 + S + E+ +L + E+ K + + + +++EE+ ++ LE Sbjct: 1389 AQQQKRS---IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQ 1445 Query: 522 ------EKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEI 575 E AL+ + E+ + ++E+ +R R+ + ++ + +A L++ +KAE Sbjct: 1446 RGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELAS--RVKAEA 1503 Query: 576 VSASESRKEL----ELKHEAEVTNYKIKLEMLEKEK--NAVLDRMAESQEAELERLRTQL 629 +A E ++ L EL+ +AE +++ +E+ + L+ S EAEL+ R Sbjct: 1504 EAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRA-- 1561 Query: 630 LFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDG--LQNEMSQKIETMQFEKDN 687 S E+ ++L+ L+ EH + + +L++ +QQ + + E +++E Q + + Sbjct: 1562 --SFAEKTAQLERSLQEEH-VAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANE 1618 Query: 688 LITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTL-EQEVQ 746 + + Q E+++ K L Q+ E +K+ E +E + +G EQ V+ Sbjct: 1619 ALRLRLQ-AEEVAQQKSLAQA--------------EAEKQKEEAEREARRRGKAEEQAVR 1663 Query: 747 ELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFL 806 + +L + LEKQ + E Q++ A AE +++ L+ T +++R + Sbjct: 1664 QRELAEQELEKQRQLAEGTAQQRLA---AEQELIR---------LRAETEQGEQQRQLLE 1711 Query: 807 DSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEI-----------EKQRNTFSFAEK 855 + + + ++E ++ ++L+ + ++ E+ E+ R+T +++ Sbjct: 1712 EEL------ARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQ 1765 Query: 856 NFEV---NYQELQEEYACLLKVKDD-------LEDSKNKQELEYK----SKLKALNEELH 901 E ++EL EE A L + ++ E+ +Q E + KL A+ E Sbjct: 1766 RLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATR 1825 Query: 902 LQRINPTTVKMKSSVFD------EDKTFVAETLEMGEVVEKDTTELMEKL-EVTKREKLE 954 L+ +K K + + ED+ F LE E + ++ E+L ++ K E Sbjct: 1826 LKTEAEIALKEKEAENERLRRLAEDEAFQRRRLE--EQAAQHKADIEERLAQLRKASDSE 1883 Query: 955 LSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDT 1014 L ++ + + L+Q+ + EE+ +LK E+ + ELE+ + R+ + + Sbjct: 1884 LERQKGLVEDTLRQRRQ----VEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS 1939 Query: 1015 QVSSLLDG-----VVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQ 1069 + + L+ + R + +V KS E + + K + E + + +E Sbjct: 1940 KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 1999 Query: 1070 LILDHLPSVTKESSLRATQPSENDKLQKE--LNVLKSEQNDLRLQMEAQRICLSLVYSTH 1127 L L+ Q + +LQ E + +Q + LQ Q+ + Sbjct: 2000 RRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ------EQSV 2053 Query: 1128 VDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLL 1187 +DQ+R E + +A +E + A+ E + +++ + E +E Sbjct: 2054 LDQLRGEAEAAR-RAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAA 2112 Query: 1188 IGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRY 1247 KL+K +E + Q + L + + E + + E Q R Sbjct: 2113 AEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE--------------QTLRQ 2158 Query: 1248 EVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSI 1307 + Q QE + TL ++ E ++ +L L ++ + T+ + + E E S+ Sbjct: 2159 KAQVEQE-LTTLRLQLEETDHQKNLLDEELQRLKAEATEAAR------QRSQVEEELFSV 2211 Query: 1308 HSQMTNLEDID--VNHKSKLSSLQDLEKTK--LEEQVQELESL------ISSLQQQLKET 1357 QM L + + +++ L+D + T+ L+E+ ++++ + +S Q+ Sbjct: 2212 RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARL 2271 Query: 1358 EQNYEAEI--------HCLQKRLQAVSEST---VPPSLPVDSVVITESDAQRTMYPGSCV 1406 Q E ++ L++++QAV E+T L + + A+R + Sbjct: 2272 RQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM 2331 Query: 1407 KKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISG 1466 + + +E + LE + Q QLE + + +A E+SR Sbjct: 2332 AQQL-----------AEETQGFQRTLEAERQRQLEMSAEAERLKLRVA-----EMSRAQA 2375 Query: 1467 GKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGK 1526 E A + A E+ + E+ + QT E + + + L + + E + Sbjct: 2376 RAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELER 2435 Query: 1527 EILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQ 1586 E + + + + T+ +E ++ T ++QS E S + R + + + Sbjct: 2436 EKEKLQQEAKLLQLKSEEMQTVQQEQLLQE-TQALQQSFLSE-KDSLLQRERFIEQEKAK 2493 Query: 1587 LEDM-------RQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQ 1639 LE + Q+L + Q QQ E RQ + ME R Q + +E ++R +L Q Sbjct: 2494 LEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQ 2553 Query: 1640 --RSSIDNENLVSERERVLLEELEALKQ---LSLAGREKLCCELRNSSTQTQNGNE 1690 + E L++E + L E+L+ L++ +LA E++ ++ NG + Sbjct: 2554 LEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRD 2609 Score = 151 bits (382), Expect = 1e-35 Identities = 318/1657 (19%), Positives = 679/1657 (40%), Gaps = 234/1657 (14%) Query: 1992 QQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDL 2051 QQLLQ E+ +E+ Q +++D ++ Q++A E ++ + L++E E Sbjct: 944 QQLLQSLEQGAQEESRCQRCISELKD-IRLQLEACETRTVHRLR--LPLDKEPARECAQR 1000 Query: 2052 RQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREV 2111 + Q + ++E + K + + + E ++ L + P + E ++ Sbjct: 1001 IAEQQKAQAEVEGLGKGVARLSAEAE--------KVLALPEPSPAAPTLRSELELTLGKL 1052 Query: 2112 EQLANHLKEKTDKCSELLL------SKEQLQRDIQERNEEIEKLEFRVRELEQALLVEDR 2165 EQ+ + +K + L E++ R +E+ +E + + + ELE + Sbjct: 1053 EQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKK 1112 Query: 2166 KHFGAVEAKPEL-SLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQ 2224 A +P +L +L+ ++ +R ++ + ++E++RE + E Q + Q Sbjct: 1113 LRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQ 1172 Query: 2225 LEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEV 2284 +++++E L++L ++ + +++ + LG ++++ Q Q + +Q ++E+ Sbjct: 1173 TDVRQRE----LEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLAD-SQAVREQLR 1227 Query: 2285 EIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRN-REEEIEQ 2343 + L E++ + + K+ + ++ I+D E Q+ + E V ++ +++ Sbjct: 1228 QEQALLEEIERHGE--KVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQS 1285 Query: 2344 LNE-VIEKLQQELANIGQKTSMNAHSLS---------EEADSLKHQLDVVIAEKLA---- 2389 +E VI++ + + T++ + + EE + L Q E+LA Sbjct: 1286 GSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEA 1345 Query: 2390 -LEQQVETANEEMTFMKNVLKETNFKMNQLTQELF--------SLKRERESVEKIQSIPE 2440 LE+Q + A +E ++ +E+ + +++R E++Q + + Sbjct: 1346 ALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQ 1405 Query: 2441 NS-VNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENG-KGSIINLETRLLQLES 2498 +S + + E + E+ ++ + Q + G +G + L R + E+ Sbjct: 1406 SSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEA 1465 Query: 2499 TVSAKDLELTQCYKQIKD-MQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQ 2557 E + +Q++D Q + Q E E+ + + E++ A + +++L+A + Sbjct: 1466 QKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQA-E 1524 Query: 2558 EYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILE 2617 E + + + + + ++ + E EL S ++ + ++LE + E H ++ Sbjct: 1525 EAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQL 1584 Query: 2618 KEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREK----------EKKRSPQDVEVLKTT 2667 +E+ E + E E+ E ++ LE + K E +++S E K Sbjct: 1585 REEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK 1644 Query: 2668 TELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQ 2727 E G E +A+R +A + EL ++ AE ++ L E + L+ + Q Sbjct: 1645 EEAEREARRRGKAEE-QAVRQRELAEQ-ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQ 1702 Query: 2728 VRDHLAEAKEKLSILEKEDETEVQ-----ESKKACMFEPLPIKLSKSIASQTDGTLKISS 2782 +E+L+ L++E Q E++ A + + + L+ ++ + S+ Sbjct: 1703 GEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR---ST 1759 Query: 2783 SNQTPQILVKNAGIQINLQSECSS----EEVTEIISQFTEKIEKMQELHAAEILDMESRH 2838 S ++ Q L AG L E + E + Q E+ Q A +L + Sbjct: 1760 SEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAA 1819 Query: 2839 ISETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREI------ 2892 I E LK E +A LKE + E + LA +A+Q R + Sbjct: 1820 IGEATRLKTEAEIA---LKE------------KEAENERLRRLAEDEAFQRRRLEEQAAQ 1864 Query: 2893 -------------CSSDSGSDWGQGIY--------------LTHSQGFDIASEGRGEES- 2924 +SDS + +G+ L F+ A+ G+ E Sbjct: 1865 HKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELEL 1924 Query: 2925 ------ESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVS--EPWLEER 2976 +A D+ K + L A Q+ + E + E+ + ++ E +R Sbjct: 1925 ELGRIRSNAEDTLRSKEQAELEAARQR--QLAAEEERRRREAEERVQKSLAAEEEAARQR 1982 Query: 2977 KAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLA--------------- 3021 KA + + LK + + + RE +S++ + + + L A Sbjct: 1983 KAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQE 2042 Query: 3022 LQQVFLEERSVL------------------LAAFRTELTALGTTDAVGLLNCLEQRIQEQ 3063 LQQ +E+SVL A + E A + V L+Q +EQ Sbjct: 2043 LQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQ 2102 Query: 3064 G---VEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQ 3120 + QAA E L+K + QA A + ++ ++ +K +++ L Q Sbjct: 2103 AQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQV 2162 Query: 3121 KQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKE 3180 +Q ++ ++++L + L E+L K E + +Q + EL +++ Q + L + Sbjct: 2163 EQ-ELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEEL-FSVRVQMEELSK 2220 Query: 3181 LEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEK---------EKAKLGRSEERDK 3231 L+A R+E +++ + ++T Q+++ +++ E+ E A+L + E D Sbjct: 2221 LKA-RIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDL 2279 Query: 3232 EELEDLKFSLESQKQRNLQLNL-------LLEQQKQLLNESQQKIESQRMLYDAQLSEE- 3283 + L + +K + +Q LL+QQK+L E ++++ + QL+EE Sbjct: 2280 AQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEET 2339 Query: 3284 QG----------RNLELQVLLESEKVRIREMSSTLDR-ERELHAQLQSSDGTGQS--RPP 3330 QG R LE+ E K+R+ EMS R E + + ++ G+ R Sbjct: 2340 QGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTE 2399 Query: 3331 LPSEDLLK-----ELQKQ-----LEEKHSRIVELLNETEKY---------KLDSLQTRQQ 3371 L +++ + E+Q+Q E I EL E EK K + +QT QQ Sbjct: 2400 LATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQ 2459 Query: 3372 ME--KDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDL--------QRQLEEKRQQVYKL 3421 + ++ Q +++ +E+++ + ++ + + ++K+E L Q+ EE+++Q ++ Sbjct: 2460 EQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQM 2519 Query: 3422 DLEGQRLQGIMQEFQKQELEREEKRESRRILYQNLNE 3458 + E QRL M+E ++++ E EE ++ Q L + Sbjct: 2520 EQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQ 2556 Score = 147 bits (370), Expect = 3e-34 Identities = 322/1585 (20%), Positives = 651/1585 (41%), Gaps = 255/1585 (16%) Query: 1858 LEAISETSSQLEHAKVTQTELMRESFRQKQEATESLK--------CQEELRERLHEESRA 1909 L+ Q++ + ++ +RE RQ+Q E ++ CQ ++ ++ Sbjct: 1201 LQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY 1260 Query: 1910 REQLAVELSK----------------AEGVIDGYADEKT-------LFERQIQEKTDIID 1946 QL ++ +E VI Y D +T L + I+ ++ + Sbjct: 1261 ELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLR 1320 Query: 1947 RLEQELLCASN-------RLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETE 1999 R+E+E A RL E+EA ++ ++ E ++ K + EA ++Q++ +E Sbjct: 1321 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1380 Query: 2000 KLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEK---NTELMDLRQQNQ 2056 + + ++ Q Q ++++LQ+ ++ E +++ + + E+ + E+ +R Q + Sbjct: 1381 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE 1440 Query: 2057 ALEKQ---LEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQ 2113 A E+Q E + L +A + E ++ Q+E ++L +Q+ Q S+ + + + Sbjct: 1441 ATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQV------QDESQRKRQAEVE 1494 Query: 2114 LANHLKEKTDKCSE---LLLSKEQLQRDIQERNEEIEKLEF-RVRELEQALLVEDRKHFG 2169 LA+ +K + + E L + E+L+ +E + + E R R+++ AL R Sbjct: 1495 LASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA 1554 Query: 2170 AVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLE---QFREELENKNEEVQQLHMQLE 2226 +++K E Q ER ++ + + L E+ E Q + E E EE ++ + + Sbjct: 1555 ELQSKRASFAEKTAQLER-SLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ 1613 Query: 2227 IQKKESTT-RLQ--ELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKE 2283 ++ E+ RLQ E+ Q+ L + + EK KE + + GK +E+ Sbjct: 1614 LKANEALRLRLQAEEVAQQKSLAQAEAEKQ----KEEAEREARRR----GK----AEEQA 1661 Query: 2284 VEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQ 2343 V +L EQ + Q+QL T + + + ELIR L ++ E E++ + Sbjct: 1662 VRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR--------LRAETE----QGEQQRQL 1709 Query: 2344 LNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTF 2403 L E + +LQ+E A QK L E ++ +++V++A K E++ + +E+ Sbjct: 1710 LEEELARLQREAAAATQKRQ----ELEAELAKVRAEMEVLLASKARAEEESRSTSEKS-- 1763 Query: 2404 MKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVN--------------VAIDH 2449 K L+ + +L +E L+ E ++ + + E AI Sbjct: 1764 -KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGE 1822 Query: 2450 LSKDKPELEVVLTE-----DALKSLENQTYF--KSFEENGKGSIINLETRLLQLESTVSA 2502 ++ K E E+ L E + L+ L F + EE ++E RL QL A Sbjct: 1823 ATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRK---A 1879 Query: 2503 KDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKF 2562 D EL + ++D Q + ++++I+ L+ E+ A +++L ++ A+ Sbjct: 1880 SDSELERQKGLVEDTLRQRR----QVEEEILALKASFEKAAAGKAELELELGRIRSNAE- 1934 Query: 2563 CQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVE 2622 T+ S+ + L R+ +L ++ R E E +V + SL E+E Sbjct: 1935 ----DTLRSKEQA----ELEAARQRQLAAEEER---RRREAEERVQK---SLAAEEEAAR 1980 Query: 2623 IAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNE 2682 K LE+ ++L K ++ RE+ ++ S + +++ + + Sbjct: 1981 -QRKAALEEVERL----KAKVEEARRLRERAEQESARQLQLAQEAAQ------------- 2022 Query: 2683 LEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSIL 2742 + L+AE KA + ++K ++LQ+ L +++ + L+ + R EA+E Sbjct: 2023 -KRLQAEE---KAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQA 2078 Query: 2743 EKE---DETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQIN 2799 E+E +V+E+++ + + + K + + + A ++ Sbjct: 2079 EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK 2138 Query: 2800 LQSECSSEEVTEIISQ-FTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLLKE 2858 ++ E+ + Q +K + QEL + + ET+ K LL E Sbjct: 2139 QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRL------QLEETDHQKN-------LLDE 2185 Query: 2859 ECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIASE 2918 E LKA +++ S + E S Q E+ + I +E Sbjct: 2186 ELQRLKAEAT-EAARQRSQVEEELFSVRVQMEELSKLKAR----------------IEAE 2228 Query: 2919 GRGE--ESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEER 2976 R + T F ++ ++ V E ++ + E ++Q++E L ++ Sbjct: 2229 NRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQ------EAARLRQLAEEDLAQQ 2282 Query: 2977 KAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAA 3036 +A K L KMQ +EA + LL Q+ +E++ L Sbjct: 2283 RALAE-----KMLKEKMQAVQEATRLKAEAE-----------LLQQQKELAQEQARRLQE 2326 Query: 3037 FRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGR 3096 + ++ + G LE Q Q +E A E L+ R + +S QA A+ + + Sbjct: 2327 DKEQMAQQLAEETQGFQRTLEAERQRQ-LEMSAEAERLKL--RVAEMSRAQA-RAEEDAQ 2382 Query: 3097 KITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAEL 3156 + + E+ EK + E Q+K + + ++++ A L+E +AEL Sbjct: 2383 RFRKQAEEIGEKLHRT--ELATQEKVTLVQTLEIQRQQSDHDAERLRE-------AIAEL 2433 Query: 3157 KSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWAL 3216 + E + KL+ E L LK E ++ + E L + SE+ + + + Sbjct: 2434 ERE--KEKLQQEAKLL----QLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFI 2487 Query: 3217 EKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLY 3276 E+EKAKL + + + + + L+ + Q+Q+ +EQ++Q L S + E++R + Sbjct: 2488 EQEKAKLEQLFQDEVAKAQQLREEQQRQQQQ-------MEQERQRLVASME--EARRRQH 2538 Query: 3277 DAQ----LSEEQGRNLELQ-----VLLESEKVRIREMSSTLDRERE---LHAQLQSSDGT 3324 +A+ +E+ + LE Q LL E R+RE L+ + H++ ++ Sbjct: 2539 EAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQV 2598 Query: 3325 GQSRPPLPSEDLLKELQKQLEEKHS 3349 ++ D L + E +HS Sbjct: 2599 AATKTLPNGRDALDGPAAEAEPEHS 2623 Score = 141 bits (356), Expect = 1e-32 Identities = 365/1881 (19%), Positives = 749/1881 (39%), Gaps = 298/1881 (15%) Query: 417 DIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALR 476 DI ++E R + +LR LD+ ++ Q + Q AQ E+E + Sbjct: 969 DIRLQLEACETRTVHRLRLPLDKEPARECAQ---RIAEQQKAQ---------AEVEGLGK 1016 Query: 477 SYSNITVNEDQIKLM---NVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQ---RQL 530 + ++ +++ + + A L +L+ T + E+++ + LE+ + R Sbjct: 1017 GVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGT 1076 Query: 531 EDLVEELSFSREQIQRARQ---TIAEQES------KLN-EAHKSLSTVEDLKAEIVSASE 580 + E L EQ++ A+ T+ E E+ KL +A T + L+ E+ A E Sbjct: 1077 QGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQE 1136 Query: 581 SRKELELKH---EAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEEL 637 + L+ +H + EV ++ ++ L + AVL + + ++ ELE+L QL + E Sbjct: 1137 VGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQ-TDVRQRELEQLGRQLRYYRESAD 1195 Query: 638 ---SKLKEDLEIEHRINIEKLKDNLGIHYK-QQIDGLQNEMS---QKIETMQ-FEKDNLI 689 + L++ + +I L D+ + + +Q L E+ +K+E Q F K + Sbjct: 1196 PLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYIN 1255 Query: 690 TKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQE----V 745 ++ + ++ L+ +K ++ + +E LR E TL + + Sbjct: 1256 AIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFI 1315 Query: 746 QELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIF 805 E + E E+ +++ + +E+ A++EA L+ +++ E + +E + Sbjct: 1316 SETLRRMEEEERLAEQQRAEERERLAEVEAA---LEKQRQLAEAHAQAKAQAEREAK--- 1369 Query: 806 LDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQ 865 ++ + ++ V +E E D +QQ + EE+++ R + +E + ++ + Sbjct: 1370 --ELQQRMQEEVVRRE-----EAAVDAQQQKRSIQEELQQLRQS---SEAEIQAKARQAE 1419 Query: 866 EEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVA 925 L++++++ + + E + + A E LQ + + + A Sbjct: 1420 AAERSRLRIEEEIRVVRLQLEATERQRGGAEGE---LQALRARAEEAE-----------A 1465 Query: 926 ETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQ 985 + + E E+ ++ ++ + ++ ++EL+ R+ +E ++K + L E L+ Sbjct: 1466 QKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE----LRL 1521 Query: 986 EKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEE 1045 + E+ R R+ E+ RA VQ + R AE + SF E+ Sbjct: 1522 QAEEAERRLRQAEV----ERARQVQVA-----------LETAQRSAEAELQSKRASFAEK 1566 Query: 1046 SKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSE 1105 + + E S QE+ + + + +E+ RA Q +E ++ ++E +E Sbjct: 1567 TAQL-------------ERSLQEEHVA--VAQLREEAERRAQQQAEAERAREE-----AE 1606 Query: 1106 QNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIH 1165 + R Q++A + + V Q + + E +K +EE +E ++ Sbjct: 1607 RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQ-----------KEEAEREARRRG 1655 Query: 1166 QLELQTMKTQETGDEG--KPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVN 1223 + E Q ++ +E ++ K L G Q+ ++ E L+ E Sbjct: 1656 KAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELI--------------RLRAETE 1701 Query: 1224 AEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQ 1283 +++ + E E LQ ++ + L KV E LL SK + Sbjct: 1702 QGEQQRQ---LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLA-----SKARAE 1753 Query: 1284 QTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQEL 1343 + E ++ L E F + + L + K + + L + Q E Sbjct: 1754 EESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ----RQLAEEDAARQRAEA 1809 Query: 1344 ESLISSLQQQLKE-TEQNYEAEIHCLQK-----RLQAVSESTVPPSLPVDSVVIT-ESDA 1396 E +++ + E T EAEI +K RL+ ++E ++ ++D Sbjct: 1810 ERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI 1869 Query: 1397 QRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFA 1456 + + + ++K D +E + G+ E+T + + Q+EEE+ + S A A Sbjct: 1870 EERL---AQLRKASDSELE--RQKGLVEDT-------LRQRRQVEEEILALKASFEKAAA 1917 Query: 1457 QQTELS----RISGGKENTASSK---------QAHAVCQQEQHY------------FNEM 1491 + EL RI E+T SK Q ++E+ E Sbjct: 1918 GKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 1977 Query: 1492 KLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDI--PESKDCVLTIS 1549 Q + + E + K +E + + E +++ L+ E K + Sbjct: 1978 AARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQ 2037 Query: 1550 EEMFSKDKTFIVRQSIHDEISVSSMDASR--------QLMLNEEQLEDMRQ----ELVRQ 1597 ++ +T QS+ D++ + A R ++ E + RQ E ++Q Sbjct: 2038 QKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQ 2097 Query: 1598 YQEHQQATELLRQAHMRQMERQREDQ--EQLQEEIKRLNRQLAQRSSIDNENLVSE---R 1652 E Q QA ++ ++ E + + Q E L ++ A + ++ +E R Sbjct: 2098 SAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLR 2157 Query: 1653 ERVLLE-ELEALK-QLSLAGREK--LCCELRNSSTQTQNGNENQGEVEEQTFKEKELDRK 1708 ++ +E EL L+ QL +K L EL+ + + +VEE+ F + + Sbjct: 2158 QKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE 2217 Query: 1709 PEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSAS 1768 + I + R + + + + L E + V E R S +Q +A Sbjct: 2218 LSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAAR-------LSVAAQEAAR 2270 Query: 1769 LIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRS 1828 L +E + + + + E+ + +++ + + +++ ++ EL+Q R Sbjct: 2271 LRQLAEEDLAQQRALAEKMLKEKMQAVQEATR-------LKAEAELLQQQKELAQEQAR- 2322 Query: 1829 GFAGTEIDPENEELMLNISSRLQAAVEKLLEAIS----ETSSQLEHAKVTQTELMRESFR 1884 + + E++ ++ Q ++ LEA E S++ E K+ E+ R R Sbjct: 2323 -----RLQEDKEQMAQQLAEETQG-FQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQAR 2376 Query: 1885 QKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDI 1944 +++A K EE+ E+LH A ++ + E Q Q+ Sbjct: 2377 AEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT--------------LEIQRQQSDHD 2422 Query: 1945 IDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKE 2004 +RL + + ELE E++++Q+E +LL + E M+ ++QLLQET+ L + Sbjct: 2423 AERLREAIA-------ELEREKEKLQQEAKLLQLKSEEMQTVQ---QEQLLQETQALQQS 2472 Query: 2005 KLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEK 2064 L +D L ++ E +E++ ++ +L Q++ + LR++ Q ++Q+E+ Sbjct: 2473 FL-------SEKDSLLQR----ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2521 Query: 2065 MRKFL---DEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEK 2121 R+ L E+A R+HE + + Q+ QQL E Q R+ E+L L E+ Sbjct: 2522 ERQRLVASMEEARRRQHEAEEGVRRKQEELQQL----------EQQRRQQEEL---LAEE 2568 Query: 2122 TDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVEDRKHFGAVEAKPELSLEV 2181 + E L E+ R +EE+ + V + D A EA+PE S + Sbjct: 2569 NQRLREQLQLLEEQHRAALAHSEEVTASQ--VAATKTLPNGRDALDGPAAEAEPEHSFD- 2625 Query: 2182 QLQAERDAIDRKEKEITNLEE 2202 L+ + A +E I + EE Sbjct: 2626 GLRRKVSAQRLQEAGILSAEE 2646 Score = 139 bits (349), Expect = 7e-32 Identities = 361/1895 (19%), Positives = 769/1895 (40%), Gaps = 224/1895 (11%) Query: 424 QETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITV 483 QE +LE L ++ Q V MK L Q + + ++ +RS+S T Sbjct: 844 QEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQL-----------IRSWSLATF 892 Query: 484 NEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQ 543 + + A++ L + Q + + G E++ +R+ S +Q Sbjct: 893 RTLKPEEQRQALHSLELHYQAFLRDSQ---DAGGFGPEDRLMAEREYGSC----SHHYQQ 945 Query: 544 IQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEML 603 + ++ + A++ES+ + +S ++D++ ++ A E+R T ++++L + Sbjct: 946 LLQSLEQGAQEESR---CQRCISELKDIRLQL-EACETR-----------TVHRLRLPLD 990 Query: 604 EKEKNAVLDRMAESQ--EAELERLRTQL--LFSHEEELSKLKEDLEIEHRINIEKLKDNL 659 ++ R+AE Q +AE+E L + L + E++ L E + E L Sbjct: 991 KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSEL---EL 1047 Query: 660 GIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQ--------SLVN 711 + +Q+ L +K++T+ + L +LK+ Q Sbjct: 1048 TLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATK 1107 Query: 712 SKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFA 771 + +++ Q Q + LR E + + + +Q+ + ++ ++ +E+ L E++ Sbjct: 1108 ASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQ 1167 Query: 772 QLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEIL-IEENE 830 + A+ + + E + L L+ + S + +L + + +++I+ + + +++ Sbjct: 1168 AVLAQTDVRQRELEQLGRQLRYYRE-SADPLGAWLQDARRR------QEQIQAMPLADSQ 1220 Query: 831 DLKQQCIQ---LNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQEL 887 +++Q Q L EEIE+ ++ + +++ L+ K LE + + Sbjct: 1221 AVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAK- 1279 Query: 888 EYKSKLKALNEELHLQRINPTTVKMK-SSVFDEDKTFVAETLEMGEVVEKDTTELMEKLE 946 K K+++ +E + + ++ T + +++ + F++ETL E E+ L E+ Sbjct: 1280 --KPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER----LAEQQR 1333 Query: 947 VTKREKLELSQRLSDLSEQLKQKHGEISFLNE-EVKSLKQEKEQVSLRCRELEIIINHNR 1005 +RE+L + + QL + H + E E K L+Q ++ +R RE + + Sbjct: 1334 AEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR-REEAAVDAQQQ 1392 Query: 1006 AENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEES 1065 ++Q Q+ + + +R AE + E S++ +E+++ + + Sbjct: 1393 KRSIQEELQQLRQSSEAEIQAKARQAEAA---------ERSRLRIEEEIRVVRLQLEATE 1443 Query: 1066 KQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYS 1125 +Q L +LRA +E + QK ++E+ ++Q E+QR + V Sbjct: 1444 RQRGGAEGEL------QALRAR--AEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVEL 1495 Query: 1126 THVDQVREYMENEKDKALCSLKEELIFAQEEKIK----ELQKIHQLELQTMKTQETGDEG 1181 + EK +AL +L+E + A+E + + E+++ Q+++ Q + + Sbjct: 1496 ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE-- 1553 Query: 1182 KPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPE 1241 +LQ + Q S+ E+ A E + + E+ E Sbjct: 1554 -------AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAE 1606 Query: 1242 LQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEE 1301 + R++++ + L + + L + K ++ + + E+ + + E Sbjct: 1607 RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRE 1666 Query: 1302 TEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNY 1361 + Q E + +L++ Q+L + + E + E + + L+++L ++ Sbjct: 1667 LAEQELEKQRQLAEG---TAQQRLAAEQELIRLRAETEQGEQQRQL--LEEELARLQREA 1721 Query: 1362 EAEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFG 1421 A QKR + +E + + V+ S A+ S +K+ +G F Sbjct: 1722 AA---ATQKRQELEAELA---KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFR 1775 Query: 1422 -VKEETNIVKLL--EKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAH 1478 + EE ++ L E + Q QL EE A + A A++ +++ E T +A Sbjct: 1776 ELAEEAARLRALAEEAKRQRQLAEEDA----ARQRAEAERVLAEKLAAIGEATRLKTEAE 1831 Query: 1479 AVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDI 1538 ++++ ++ + FQ + L ++ +H DI Sbjct: 1832 IALKEKEAENERLRRLAEDEAFQR------------RRLEEQAAQHKA----------DI 1869 Query: 1539 PESKDCVLTISEEMFSKDKTFI---VRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELV 1595 E + S+ + K + +RQ E + ++ AS + + ++ + Sbjct: 1870 EERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRI 1929 Query: 1596 RQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERV 1655 R A + LR ++E R+ Q +EE +R + + S+ E + + + Sbjct: 1930 RS-----NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA 1984 Query: 1656 LLEELEALKQLSLAGREKLCCELRNSSTQTQNGNEN-----QGEVEEQTF----KEKELD 1706 LEE+E LK R + S+ Q Q E Q E + F KE+EL Sbjct: 1985 ALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQ 2044 Query: 1707 R--KPEDVPPEILSNE----RYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRS 1760 + + E + L E R A ++A ++ E ++ VEE L +S Sbjct: 2045 QTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER------LKQS 2098 Query: 1761 SKSQSSASLIWRSEAEASVKSCVHEEHTRVTDE--SIPSYSGSDMPRNDINMWSKVT-EE 1817 ++ Q+ A ++ AE K E R E ++ +D +++ T + Sbjct: 2099 AEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ 2158 Query: 1818 GTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTE 1877 ++ Q L E D + + L+ RL+A + S+ +L +V E Sbjct: 2159 KAQVEQELTTLRLQLEETDHQ-KNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE 2217 Query: 1878 LMRESFR-QKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFER 1936 L + R + + L+ ++ + L EE+ +Q+A E ++ A + L E Sbjct: 2218 LSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE 2277 Query: 1937 QIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQ 1996 + ++ + +++ +E + A L+AE + +Q+++EL Q ++ + + QQL + Sbjct: 2278 DLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAE 2337 Query: 1997 ETEKLMK-------EKLEVQCQAEKVR--------------DDLQKQVKALEIDVEEQVS 2035 ET+ + +LE+ +AE+++ +D Q+ K E ++ E++ Sbjct: 2338 ETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE-EIGEKLH 2396 Query: 2036 RFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLK 2095 R QEK T + L Q Q + E++R+ + E E E++ QQE + L QLK Sbjct: 2397 RTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAEL----EREKEKLQQEAKLL--QLK 2450 Query: 2096 VVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKE----QLQRDIQERNEEIEKL-- 2149 E QT + EQL ++T + LS++ Q +R I++ ++E+L Sbjct: 2451 S-------EEMQTVQQEQLL----QETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQ 2499 Query: 2150 -----EFRVRELEQALLVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQL 2204 ++RE +Q + + + A E + Q +AE + + RK++E+ LE+Q Sbjct: 2500 DEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAE-EGVRRKQEELQQLEQQR 2558 Query: 2205 EQFREELENKNEEVQQLHMQLEIQKKESTTRLQEL 2239 Q E L +N+ +++ LE Q + + +E+ Sbjct: 2559 RQQEELLAEENQRLREQLQLLEEQHRAALAHSEEV 2593 Score = 125 bits (315), Expect = 6e-28 Identities = 335/1644 (20%), Positives = 647/1644 (39%), Gaps = 231/1644 (14%) Query: 2109 REVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEF-RVRELEQALLVEDRKH 2167 RE ++H ++ + + + QR I E + +LE R + + L D++ Sbjct: 934 REYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEP 993 Query: 2168 FGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEI 2227 A E ++ + + QAE + + K + L + E+ L + L +LE+ Sbjct: 994 --ARECAQRIAEQQKAQAEVEGLG---KGVARLSAEAEKVLA-LPEPSPAAPTLRSELEL 1047 Query: 2228 QKKESTTRLQELEQENKLFKDDMEKLGLAIKESD-AMSTQDQHVLFGKFAQIIQEKEVEI 2286 + +L+++ + ++ + ++ + L I+ + A H K AQ + E+ Sbjct: 1048 ----TLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPEL 1103 Query: 2287 DQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNE 2346 + + KL+ Q + + + +R + E L R+ E+E+ E Sbjct: 1104 EATKASLKKLRAQAE--AQQPTFDALRDELRGAQEVGERLQQRHG----ERDVEVERWRE 1157 Query: 2347 VIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKL-ALEQQVETANEEMTFMK 2405 + +L + + +T + L + L++ + A+ L A Q E++ M Sbjct: 1158 RVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRES--ADPLGAWLQDARRRQEQIQAMP 1215 Query: 2406 NVLKETNFKMNQLTQE---LFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLT 2462 L ++ QL QE L ++R E VE+ Q + +N D+ EL++V Sbjct: 1216 --LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY------ELQLVTY 1267 Query: 2463 EDALKSLENQTYFKSFEENGKGSII----NLETRLLQLESTVSAKDLELTQCYKQIKDMQ 2518 + L+ + + K ++G S+I +L T +L + S +++ +++++ + Sbjct: 1268 KAQLEPVASPAK-KPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEE 1326 Query: 2519 EQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNI 2578 + Q++ +++ E V AAL Q QL AK +E E + Sbjct: 1327 RLAE------QQRAEERERLAE--VEAALEKQRQLAEAHAQAK-------AQAEREAKEL 1371 Query: 2579 QNLNQ---LREDELGSDISALTLRISELESQVVEMHTSLILEK-EQVEIAEKNVLEKEKK 2634 Q Q +R +E D I E Q+ + + I K Q E AE++ L E++ Sbjct: 1372 QQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEE 1431 Query: 2635 LLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATK 2694 + ++ LE E+++ G EL+ALRA + + Sbjct: 1432 IRVVRLQLEATERQR---------------------------GGAEGELQALRARAEEAE 1464 Query: 2695 AELASYKEKAEKLQEELLVKETNMTSLQKDL-SQVRDHLAEAKEKLSILEKEDETEVQES 2753 A+ +E+AE+L+ ++ + + +L S+V+ A+EK L+ +E +Q Sbjct: 1465 AQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAE 1524 Query: 2754 KKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGI-QINLQSECSSEEVTEI 2812 + ++ ++ Q L+ + + ++ K A + Q E S +E Sbjct: 1525 EAERRLRQAEVERAR----QVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVA 1580 Query: 2813 ISQFTEKIEKMQELHA-AEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLR 2871 ++Q E+ E+ + A AE E+ E LK + ++L EE K++ Q Sbjct: 1581 VAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEA 1640 Query: 2872 SKEGSSIPE------LAHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESE 2925 K+ A A + RE+ + +EG ++ Sbjct: 1641 EKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ-------------LAEGTAQQRL 1687 Query: 2926 SATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSI-----QQVSEPWLEERKAYI 2980 +A + LRA +G Q L E + + + +Q E L + +A + Sbjct: 1688 AAEQELIR-----LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEM 1742 Query: 2981 NTISSLK--------DLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSV 3032 + + K K + + EAE + E + R A +Q L E Sbjct: 1743 EVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDA 1802 Query: 3033 LLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQK-----ADRRSLLSEIQ 3087 E A+G L+ + E +A E L++ A +R L E Sbjct: 1803 ARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA 1862 Query: 3088 ALH-AQMNGRKITLKREQESEKPSQE-LLEYNIQQKQSQMLEMQVELSSMKDRATELQEQ 3145 A H A + R L++ +SE Q+ L+E ++Q++ +++ E+ ++K Sbjct: 1863 AQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRR----QVEEEILALK--------- 1909 Query: 3146 LSSEKMVV--AELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLA 3203 S EK AEL+ EL + + E TL++ K ELEA R A Sbjct: 1910 ASFEKAAAGKAELELELGRIRSNAEDTLRS--KEQAELEAARQR------------QLAA 1955 Query: 3204 SEQKKSRELQWALEKEKA---KLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQ 3260 E+++ RE + ++K A + R + EE+E LK +E ++ + +Q Q Sbjct: 1956 EEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQ 2015 Query: 3261 LLNESQQK---IESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDREREL--- 3314 L E+ QK E + + Q E+ ELQ L+ E+ + ++ + R Sbjct: 2016 LAQEAAQKRLQAEEKAHAFAVQQKEQ-----ELQQTLQQEQSVLDQLRGEAEAARRAAEE 2070 Query: 3315 --HAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIV----ELLNETEKYKLDSLQT 3368 A++Q+ QSR + + LK+ ++ + ++ +L E E+ Q Sbjct: 2071 AEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQA 2130 Query: 3369 RQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRL 3428 Q + +Q ++ ++ + ++ +++ ++ L+ QLEE Q LD E QRL Sbjct: 2131 EQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRL 2190 Query: 3429 QGIMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYA 3488 + E +Q + EE+ S R+ + L++ L+ +IE E + Sbjct: 2191 KAEATEAARQRSQVEEELFSVRVQMEELSK---------------LKARIEAENR----- 2230 Query: 3489 KLIEMNGGGTGCNHELEMIRQKLQCVASKLQVLPQKASERLQFETADDEDFIWVQENIDE 3548 LI + T L+ +K++ VA + L A E + +ED + Q + E Sbjct: 2231 ALILRDKDNT--QRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED-LAQQRALAE 2287 Query: 3549 IILQLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKL 3608 +L+ E+ V +T + E LL+Q EL ++ +E D M +L Sbjct: 2288 KMLK---------EKMQAVQEATRLKAEAE-LLQQQKELAQEQARRLQE--DKEQMAQQL 2335 Query: 3609 EEQIRWYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRAE--AEVY 3666 E+ + +++T L + +++E E + ++ RAE A+ + Sbjct: 2336 AEETQGFQRT-----------LEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRF 2384 Query: 3667 KLKAELRNDSLLQTLSPDSEHVTL 3690 + +AE + L +T E VTL Sbjct: 2385 RKQAEEIGEKLHRTELATQEKVTL 2408 Score = 48.5 bits (114), Expect = 1e-04 Identities = 142/683 (20%), Positives = 274/683 (40%), Gaps = 64/683 (9%) Query: 3052 LLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNG---RKITLKREQESEK 3108 LL LEQ QE+ C + +SE++ + Q+ R + R ++ Sbjct: 946 LLQSLEQGAQEES-------RC------QRCISELKDIRLQLEACETRTVHRLRLPLDKE 992 Query: 3109 PSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQT-KLEL 3167 P++E + +Q+++Q E+ + L + +EK++ S A T + EL Sbjct: 993 PARECAQRIAEQQKAQ-----AEVEGLGKGVARLSAE--AEKVLALPEPSPAAPTLRSEL 1045 Query: 3168 ETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSE 3227 E TL + + ++ L A LE K KT + + A E ++ E Q + Sbjct: 1046 ELTL-GKLEQVRSLSAIYLE-KLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPEL 1103 Query: 3228 ERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRN 3287 E K L+ L+ E+Q+ L L +++ QQ+ +R + + E + Sbjct: 1104 EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQR-HGERDVEVERWRERVAQL 1162 Query: 3288 LEL-QVLLESEKVRIREMSST---LDRERE----LHAQLQSSDGTGQSRPPLPSEDLLKE 3339 LE Q +L VR RE+ L RE L A LQ + + +P D + Sbjct: 1163 LERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADS-QA 1221 Query: 3340 LQKQLEEKHSRIVELLNETEKYKLDSLQTRQQME--KDRQVHRKTLQTEQEANTEGQKKM 3397 +++QL ++ + + E+ EK + +Q + KD ++ T + + E KK Sbjct: 1222 VREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKP 1281 Query: 3398 HELQSKVEDLQRQLEEKRQQVYKLD-LEGQRLQGIMQEFQKQELEREEKRESRRILYQNL 3456 ++QS E + ++ + R +L L Q ++ I + ++ E E + R + L Sbjct: 1282 -KVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERL 1340 Query: 3457 NEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMI--RQKLQCV 3514 E +L R + + + + + AK ++ E + +Q+ + + Sbjct: 1341 AEVEA-ALEKQRQ---LAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSI 1396 Query: 3515 ASKLQVLPQKASERLQFET----ADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSPS 3570 +LQ L Q + +Q + A + + ++E I + LQL+ Q+G + Sbjct: 1397 QEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL 1456 Query: 3571 TSCGSLTERLLRQNAELTGHIS-QLTEEKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRFS 3629 + E RQ E + Q+ +E R ++L +++ + A R+ Sbjct: 1457 RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVK--AEAEAAREKQRALQ 1514 Query: 3630 LNGGANIEAIIA------SEKEVWNREKLTLQKSLKRAEAEVYKLKAELRNDSLLQTLSP 3683 ++A A +E E + ++ L+ + + AEAE+ +A + S Sbjct: 1515 ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1574 Query: 3684 DSEHVTLKRIYGKYLRAESFRKA 3706 EHV + + LR E+ R+A Sbjct: 1575 QEEHVAVAQ-----LREEAERRA 1592 Score = 35.8 bits (81), Expect = 0.85 Identities = 52/235 (22%), Positives = 101/235 (42%), Gaps = 31/235 (13%) Query: 2138 DIQE--RNEEIEKLEFRVRELEQALLVEDRKHFGAVEAK--PELSLEVQLQAERDAIDRK 2193 D+Q+ R E++ REL LL R H A E + P E+++ + + K Sbjct: 245 DVQDGVRANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQ-FLKFK 303 Query: 2194 EKEITNLEEQLEQFREELENKNEEVQQLHMQ-------LEIQKKESTTRLQELEQENKLF 2246 E E+ E + + ++ VQ ++ L+++K+ + LE+E +L Sbjct: 304 EMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQL- 362 Query: 2247 KDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDN 2306 + + E+L Q ++ ++ E + +QLN+ LQ +++ Sbjct: 363 RSEFERLECL-----------QRIV----TKLQMEAGLCEEQLNQADALLQSDVRLLAAG 407 Query: 2307 KVIEEKNELIRDL---ETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANI 2358 KV + E+ RDL ++ I L +D + +K R + EQ+ + +L + L I Sbjct: 408 KVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAI 462 Score = 35.8 bits (81), Expect = 0.85 Identities = 60/292 (20%), Positives = 111/292 (38%), Gaps = 39/292 (13%) Query: 4 EERQKKLEAGKAKLAQFR-------QRKAQSDGQ-----SPSKKQKKKRKTSSSKHDVSA 51 +E+ ++L+ K ++AQ QR +++ Q S ++ K R S+ A Sbjct: 2318 QEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA 2377 Query: 52 HHDLNIDQSQCNEMYINSSQRVESTVIPESTIMRTLH-SGEITSHEQGFSVELESEISTT 110 D + Q E+ R E + T+++TL + + H+ E +E+ Sbjct: 2378 EEDAQRFRKQAEEIG-EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELERE 2436 Query: 111 ADDCSSEVNGCSFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHE 170 + E K L EE V Q Q + L ++ Sbjct: 2437 KEKLQQEA----------KLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERF 2486 Query: 171 IEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLE 230 IE+ +LE++ + Q +E + +Q + +L A++++ARR + E Sbjct: 2487 IEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRR 2546 Query: 231 LTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDH 282 E+ Q+L+ Q +Q + +LL + Q L Q QL E+ H Sbjct: 2547 KQEELQQLEQQRRQQE---------------ELLAEENQRLREQLQLLEEQH 2583 >gi|41322912 plectin 1 isoform 2 [Homo sapiens] Length = 4533 Score = 192 bits (487), Expect = 7e-48 Identities = 274/1260 (21%), Positives = 544/1260 (43%), Gaps = 171/1260 (13%) Query: 1579 QLMLNEEQLEDMRQE---LVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNR 1635 +++ EE D +Q+ + + Q+ +Q++E QA RQ E + +++EEI+ + Sbjct: 1386 EVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRL 1445 Query: 1636 QLA----QRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNEN 1691 QL QR + E + R EE EA K+ + E+L ++++ S Q + Sbjct: 1446 QLEATERQRGGAEGE---LQALRARAEEAEAQKRQAQEEAERLRRQVQDES---QRKRQA 1499 Query: 1692 QGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGR 1751 + E+ + E E R+ + + L R ++A RL + +E + ET Sbjct: 1500 EVELASRVKAEAEAAREKQRAL-QALEELRLQAEEAERRLRQAEVERARQVQVALETA-- 1556 Query: 1752 HVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMW 1811 RS++++ + +E A ++ + EEH V Sbjct: 1557 ------QRSAEAELQSKRASFAEKTAQLERSLQEEHVAV--------------------- 1589 Query: 1812 SKVTEEGTELSQRLVRSGFAGTEIDPENE--ELMLNISSRLQAAVEKLLEAISETSSQLE 1869 +++ EE +Q+ + A E + E E +L N + RL+ E++ + S ++ E Sbjct: 1590 AQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE 1649 Query: 1870 HAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYAD 1929 K E RE+ R+ + ++++ +E + L ++ + E A + AE + Sbjct: 1650 KQK---EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRA 1706 Query: 1930 EKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELL------------- 1976 E E+Q Q + + RL++E A+ + QELEAE +++ E E+L Sbjct: 1707 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS 1766 Query: 1977 --SRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQV 2034 + K+ ++AEAG ++L +E +L E + Q + +D +Q E + E++ Sbjct: 1767 TSEKSKQRLEAEAGRF-RELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKL 1825 Query: 2035 SRFIE---LEQEKNTELMDLRQQNQALEKQLEK---MRKFLDEQAIDREHERDVFQQEIQ 2088 + E L+ E L + +N+ L + E R+ L+EQA +H+ D+ ++ Q Sbjct: 1826 AAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA--AQHKADIEERLAQ 1883 Query: 2089 KLEQQLKVVPRFQPISE---HQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEE 2145 + + R + + E Q R+VE+ LK +K + K +L+ ++ Sbjct: 1884 LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAA---AGKAELELELGRIRSN 1940 Query: 2146 IEKLEFRVRELEQALLVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLE 2205 E +R EQA L R+ A E + + R+A +R +K + EE Sbjct: 1941 AED---TLRSKEQAELEAARQRQLAAEEE---------RRRREAEERVQKSLAAEEEAAR 1988 Query: 2206 QFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMST 2265 Q + L EEV++L ++E ++ QE ++ +L ++ +K A +++ A + Sbjct: 1989 QRKAAL----EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAV 2044 Query: 2266 QDQHVLFGKFAQIIQEKEVEIDQLNEQV------------TKLQQQLKITTDNKVIEEKN 2313 Q + + Q +Q+++ +DQL + ++Q + + + +EE Sbjct: 2045 QQKE---QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAE 2101 Query: 2314 ELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEA 2373 L + E Q + Q ++ R+E + E + Q E A + QK + +A E Sbjct: 2102 RLKQSAEEQAQARAQAQAAAEKLRKEAEQ---EAARRAQAEQAALRQKQAADA-----EM 2153 Query: 2374 DSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVE 2433 + K + + +K +EQ E+T ++ L+ET+ + N L +EL LK E Sbjct: 2154 EKHKKFAEQTLRQKAQVEQ-------ELTTLRLQLEETDHQKNLLDEELQRLKAEATEAA 2206 Query: 2434 KIQSIPEN---SVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLE 2490 + +S E SV V ++ LSK K +E L+ +N F EE K + E Sbjct: 2207 RQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQ-EEAEKMKQVAEE 2265 Query: 2491 TRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQ 2550 L + + +A+ +L + +D+ +Q +ML++K+ +Q+ K A L+ Q Sbjct: 2266 AARLSVAAQEAARLRQLAE-----EDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQ 2320 Query: 2551 IQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQL------REDELGSDISALTLRISEL- 2603 Q E QE A+ Q+++ ++ Q + R+ E+ ++ L LR++E+ Sbjct: 2321 -QKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMS 2379 Query: 2604 -----------------ESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNE 2646 E ++H + + +E+V + + +++++ + ++L E Sbjct: 2380 RAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIA 2439 Query: 2647 KKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAEL-------AS 2699 + +REKEK + Q+ ++L+ +E + ++ E +AL+ ++ K L Sbjct: 2440 ELEREKEKLQ--QEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQ 2497 Query: 2700 YKEKAEKLQEELLVKETNMTS----LQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKK 2755 K K E+L ++ + K + Q+ + Q R L + E+ + E E V+ ++ Sbjct: 2498 EKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQE 2557 Score = 171 bits (433), Expect = 1e-41 Identities = 345/1688 (20%), Positives = 693/1688 (41%), Gaps = 223/1688 (13%) Query: 1837 PENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQ 1896 PE + S L+ + KL + S ++ LE K + R Q A E L+ Sbjct: 1040 PEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVI-----RGTQGAEEVLRAH 1094 Query: 1897 EELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCAS 1956 EE + +E AV + E + +K + + Q+ T D L EL A Sbjct: 1095 EE---------QLKEAQAVPATLPELEATKASLKKLRAQAEAQQPT--FDALRDELRGA- 1142 Query: 1957 NRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVR 2016 QE+ QQ ER++ + A+ Q +L +T+ +E ++ Q R Sbjct: 1143 ---QEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYR 1199 Query: 2017 DDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDE-QAID 2075 + L+ D + + + + + + +Q QAL +++E+ + ++E Q Sbjct: 1200 ESADPLGAWLQ-DARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFA 1258 Query: 2076 REHERDVFQQEIQKL--EQQLKVV------PRFQPISEHQTREVEQLANHLKEKTDKCSE 2127 +++ + E+Q + + QL+ V P+ Q SE +E L H E T S+ Sbjct: 1259 KQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQ 1318 Query: 2128 LL--LSKEQLQRDIQERNEEIEKLEFRVRELEQALLVEDRKHFGAVEAKPELSLEVQLQA 2185 + +S+ + + +ER E ++ E R R E +E ++ A + + QA Sbjct: 1319 YIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHA------QAKAQA 1372 Query: 2186 ERDAID---RKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQE 2242 ER+A + R ++E+ EE +++ + EE+QQL E + + + + E+ Sbjct: 1373 EREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERS 1432 Query: 2243 NKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKI 2302 ++++ + L ++ ++ + L A+ +E E + Q E+ +L++Q Sbjct: 1433 RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARA-EEAEAQKRQAQEEAERLRRQ--- 1488 Query: 2303 TTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKT 2362 ++++++ R E ++ + + R ++ ++ L E+ +LQ Sbjct: 1489 ------VQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL--RLQ---------- 1530 Query: 2363 SMNAHSLSEEADSLKHQLDVVIAEKL--ALEQQVETANEEMTFMKNVLKETNFKMNQLTQ 2420 +EEA+ Q +V A ++ ALE +A E+ + E ++ + Sbjct: 1531 -------AEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLER--- 1580 Query: 2421 ELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEE 2480 SL+ E +V +++ E + + + E E L LK+ E Sbjct: 1581 ---SLQEEHVAVAQLREEAERRAQQQAE-AERAREEAERELERWQLKANEA--------- 1627 Query: 2481 NGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQ----GQFETEMLQKKIVNLQ 2536 L RL Q E K L + KQ ++ + + G+ E + ++++ + Q Sbjct: 1628 --------LRLRL-QAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1678 Query: 2537 KIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGS---DI 2593 ++ +++ A +Q +L A QE + + +E E+ Q QL E+EL + Sbjct: 1679 ELEKQRQLAEGTAQQRLAAEQELIR-------LRAETEQGEQQR--QLLEEELARLQREA 1729 Query: 2594 SALTLRISELESQVVEMHTS---LILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQR 2650 +A T + ELE+++ ++ L+ K + E ++ EK K+ LE E ++ Sbjct: 1730 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA----EAGRFREL 1785 Query: 2651 EKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALR--AESVATKAELASYKEKAEKLQ 2708 +E R E K +L EE EA R AE +A E K +AE Sbjct: 1786 AEEAARLRALAEEAKRQRQLA---EEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIAL 1842 Query: 2709 EELLVKETNMTSLQKDLS--------QVRDHLAEAKEKLSILEKEDETEVQESK------ 2754 +E + + L +D + Q H A+ +E+L+ L K ++E++ K Sbjct: 1843 KEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDT 1902 Query: 2755 ----KACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVT 2810 + E L +K S A+ L++ I+ N + S+E Sbjct: 1903 LRQRRQVEEEILALKASFEKAAAGKAELELELGR-----------IRSNAEDTLRSKEQA 1951 Query: 2811 EIISQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCL 2870 E+ + ++ +E E + + ++ E R+ A+ EE LKA ++ Sbjct: 1952 ELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL----EEVERLKAKVEEA 2007 Query: 2871 R------SKEGSSIPELAHSDAY---QTREICSSDSGSDWGQGIYLTHSQGFDIASEGRG 2921 R +E + +LA A Q E + + Q + T Q + + RG Sbjct: 2008 RRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRG 2067 Query: 2922 EESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYIN 2981 E +E+A + A E +V + E+ S + +++ + E+ +A Sbjct: 2068 E-AEAARRA----------AEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQ 2116 Query: 2982 TISSLKDLITKMQLQ--REAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRT 3039 ++ + L + + + R A+ ++ + +D E + L +++ + T Sbjct: 2117 AQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTT 2176 Query: 3040 ELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADR-----RSLLSEIQALHAQMN 3094 L TD N L++ +Q E A + + R + E+ L A++ Sbjct: 2177 LRLQLEETDHQK--NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIE 2234 Query: 3095 G--RKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATEL---------Q 3143 R + L+ + +++ QE E K Q+ E LS A L Q Sbjct: 2235 AENRALILRDKDNTQRFLQEEAE-----KMKQVAEEAARLSVAAQEAARLRQLAEEDLAQ 2289 Query: 3144 EQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLA 3203 ++ +EKM+ ++++ T+L+ E L Q K L + +A RL+ + L +T Sbjct: 2290 QRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQG 2349 Query: 3204 S----EQKKSRELQWALEKEKAKL-----GRSEERDKEELEDLKFSLESQKQRNLQLNLL 3254 E ++ R+L+ + E E+ KL R++ R +E+ + + E ++ L L Sbjct: 2350 FQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEK-LHRTEL 2408 Query: 3255 LEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDREREL 3314 Q+K L ++ + I+ Q+ +DA+ E LE + ++ ++ ++ S + + Sbjct: 2409 ATQEKVTLVQTLE-IQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQ 2467 Query: 3315 HAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNE----TEKYKLDSLQTRQ 3370 LQ + QS L +D L + ++ +E++ +++ +L + ++ + + + +Q Sbjct: 2468 EQLLQETQALQQSF--LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQ 2525 Query: 3371 QMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQG 3430 QME++RQ + + + +EA + ++ K E+LQ+ +++RQQ L E QRL+ Sbjct: 2526 QMEQERQ---RLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLRE 2582 Query: 3431 IMQEFQKQ 3438 +Q ++Q Sbjct: 2583 QLQLLEEQ 2590 Score = 158 bits (399), Expect = 1e-37 Identities = 323/1676 (19%), Positives = 685/1676 (40%), Gaps = 242/1676 (14%) Query: 153 SPTHLEMMESELAGKQHEIEELNR-ELEEMR----VTYGTEGLQQ-LQEFEAAIKQRDGI 206 +PT +E L GK ++ L+ LE+++ V GT+G ++ L+ E +K+ + Sbjct: 1046 APTLRSELELTL-GKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAV 1104 Query: 207 ITQLT------ANLQQARREKDETMREFLELTEQ---SQKLQIQFQQLQASETLRNSTHS 257 L A+L++ R + + F L ++ +Q++ + QQ + Sbjct: 1105 PATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWR 1164 Query: 258 STAADLLQAKQQILTH----QQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQD 313 A LL+ Q +L Q++LE+ L Y++ + ++LQ+ + E Q Sbjct: 1165 ERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLG---AWLQDARRRQEQIQA 1221 Query: 314 KKVENSN--KEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQ 371 + +S +E++++++ ++EE+ +K E + + + + Q+V Sbjct: 1222 MPLADSQAVREQLRQEQALLEEIE----RHGEKVEECQRFAKQYINAIKDYELQLVTYKA 1277 Query: 372 EIKNMKLELTNSKQKERQSS--EEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRK 429 +++ + K + S +E L EL + +F ++ ++RME+E +R Sbjct: 1278 QLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEE-ERL 1336 Query: 430 LEQLRAE-----------------LDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEME 472 EQ RAE L E + Q Q ++E EE+ R + ++ Sbjct: 1337 AEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVD 1396 Query: 473 NALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKE---KLKEELGLI---LE----- 521 + S + E+ +L + E+ K + + + +++EE+ ++ LE Sbjct: 1397 AQQQKRS---IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQ 1453 Query: 522 ------EKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEI 575 E AL+ + E+ + ++E+ +R R+ + ++ + +A L++ +KAE Sbjct: 1454 RGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELAS--RVKAEA 1511 Query: 576 VSASESRKEL----ELKHEAEVTNYKIKLEMLEKEK--NAVLDRMAESQEAELERLRTQL 629 +A E ++ L EL+ +AE +++ +E+ + L+ S EAEL+ R Sbjct: 1512 EAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRA-- 1569 Query: 630 LFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDG--LQNEMSQKIETMQFEKDN 687 S E+ ++L+ L+ EH + + +L++ +QQ + + E +++E Q + + Sbjct: 1570 --SFAEKTAQLERSLQEEH-VAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANE 1626 Query: 688 LITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTL-EQEVQ 746 + + Q E+++ K L Q+ E +K+ E +E + +G EQ V+ Sbjct: 1627 ALRLRLQ-AEEVAQQKSLAQA--------------EAEKQKEEAEREARRRGKAEEQAVR 1671 Query: 747 ELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFL 806 + +L + LEKQ + E Q++ A AE +++ L+ T +++R + Sbjct: 1672 QRELAEQELEKQRQLAEGTAQQRLA---AEQELIR---------LRAETEQGEQQRQLLE 1719 Query: 807 DSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEI-----------EKQRNTFSFAEK 855 + + + ++E ++ ++L+ + ++ E+ E+ R+T +++ Sbjct: 1720 EEL------ARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQ 1773 Query: 856 NFEV---NYQELQEEYACLLKVKDD-------LEDSKNKQELEYK----SKLKALNEELH 901 E ++EL EE A L + ++ E+ +Q E + KL A+ E Sbjct: 1774 RLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATR 1833 Query: 902 LQRINPTTVKMKSSVFD------EDKTFVAETLEMGEVVEKDTTELMEKL-EVTKREKLE 954 L+ +K K + + ED+ F LE E + ++ E+L ++ K E Sbjct: 1834 LKTEAEIALKEKEAENERLRRLAEDEAFQRRRLE--EQAAQHKADIEERLAQLRKASDSE 1891 Query: 955 LSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDT 1014 L ++ + + L+Q+ + EE+ +LK E+ + ELE+ + R+ + + Sbjct: 1892 LERQKGLVEDTLRQRRQ----VEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS 1947 Query: 1015 QVSSLLDG-----VVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQ 1069 + + L+ + R + +V KS E + + K + E + + +E Sbjct: 1948 KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 2007 Query: 1070 LILDHLPSVTKESSLRATQPSENDKLQKE--LNVLKSEQNDLRLQMEAQRICLSLVYSTH 1127 L L+ Q + +LQ E + +Q + LQ Q+ + Sbjct: 2008 RRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ------EQSV 2061 Query: 1128 VDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLL 1187 +DQ+R E + +A +E + A+ E + +++ + E +E Sbjct: 2062 LDQLRGEAEAAR-RAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAA 2120 Query: 1188 IGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRY 1247 KL+K +E + Q + L + + E + + E Q R Sbjct: 2121 AEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE--------------QTLRQ 2166 Query: 1248 EVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSI 1307 + Q QE + TL ++ E ++ +L L ++ + T+ + + E E S+ Sbjct: 2167 KAQVEQE-LTTLRLQLEETDHQKNLLDEELQRLKAEATEAAR------QRSQVEEELFSV 2219 Query: 1308 HSQMTNLEDID--VNHKSKLSSLQDLEKTK--LEEQVQELESL------ISSLQQQLKET 1357 QM L + + +++ L+D + T+ L+E+ ++++ + +S Q+ Sbjct: 2220 RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARL 2279 Query: 1358 EQNYEAEI--------HCLQKRLQAVSEST---VPPSLPVDSVVITESDAQRTMYPGSCV 1406 Q E ++ L++++QAV E+T L + + A+R + Sbjct: 2280 RQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM 2339 Query: 1407 KKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISG 1466 + + +E + LE + Q QLE + + +A E+SR Sbjct: 2340 AQQL-----------AEETQGFQRTLEAERQRQLEMSAEAERLKLRVA-----EMSRAQA 2383 Query: 1467 GKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGK 1526 E A + A E+ + E+ + QT E + + + L + + E + Sbjct: 2384 RAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELER 2443 Query: 1527 EILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQ 1586 E + + + + T+ +E ++ T ++QS E S + R + + + Sbjct: 2444 EKEKLQQEAKLLQLKSEEMQTVQQEQLLQE-TQALQQSFLSE-KDSLLQRERFIEQEKAK 2501 Query: 1587 LEDM-------RQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQ 1639 LE + Q+L + Q QQ E RQ + ME R Q + +E ++R +L Q Sbjct: 2502 LEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQ 2561 Query: 1640 --RSSIDNENLVSERERVLLEELEALKQ---LSLAGREKLCCELRNSSTQTQNGNE 1690 + E L++E + L E+L+ L++ +LA E++ ++ NG + Sbjct: 2562 LEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRD 2617 Score = 151 bits (382), Expect = 1e-35 Identities = 318/1657 (19%), Positives = 679/1657 (40%), Gaps = 234/1657 (14%) Query: 1992 QQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDL 2051 QQLLQ E+ +E+ Q +++D ++ Q++A E ++ + L++E E Sbjct: 952 QQLLQSLEQGAQEESRCQRCISELKD-IRLQLEACETRTVHRLR--LPLDKEPARECAQR 1008 Query: 2052 RQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREV 2111 + Q + ++E + K + + + E ++ L + P + E ++ Sbjct: 1009 IAEQQKAQAEVEGLGKGVARLSAEAE--------KVLALPEPSPAAPTLRSELELTLGKL 1060 Query: 2112 EQLANHLKEKTDKCSELLL------SKEQLQRDIQERNEEIEKLEFRVRELEQALLVEDR 2165 EQ+ + +K + L E++ R +E+ +E + + + ELE + Sbjct: 1061 EQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKK 1120 Query: 2166 KHFGAVEAKPEL-SLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQ 2224 A +P +L +L+ ++ +R ++ + ++E++RE + E Q + Q Sbjct: 1121 LRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQ 1180 Query: 2225 LEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEV 2284 +++++E L++L ++ + +++ + LG ++++ Q Q + +Q ++E+ Sbjct: 1181 TDVRQRE----LEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLAD-SQAVREQLR 1235 Query: 2285 EIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRN-REEEIEQ 2343 + L E++ + + K+ + ++ I+D E Q+ + E V ++ +++ Sbjct: 1236 QEQALLEEIERHGE--KVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQS 1293 Query: 2344 LNE-VIEKLQQELANIGQKTSMNAHSLS---------EEADSLKHQLDVVIAEKLA---- 2389 +E VI++ + + T++ + + EE + L Q E+LA Sbjct: 1294 GSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEA 1353 Query: 2390 -LEQQVETANEEMTFMKNVLKETNFKMNQLTQELF--------SLKRERESVEKIQSIPE 2440 LE+Q + A +E ++ +E+ + +++R E++Q + + Sbjct: 1354 ALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQ 1413 Query: 2441 NS-VNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENG-KGSIINLETRLLQLES 2498 +S + + E + E+ ++ + Q + G +G + L R + E+ Sbjct: 1414 SSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEA 1473 Query: 2499 TVSAKDLELTQCYKQIKD-MQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQ 2557 E + +Q++D Q + Q E E+ + + E++ A + +++L+A + Sbjct: 1474 QKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQA-E 1532 Query: 2558 EYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILE 2617 E + + + + + ++ + E EL S ++ + ++LE + E H ++ Sbjct: 1533 EAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQL 1592 Query: 2618 KEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREK----------EKKRSPQDVEVLKTT 2667 +E+ E + E E+ E ++ LE + K E +++S E K Sbjct: 1593 REEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK 1652 Query: 2668 TELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQ 2727 E G E +A+R +A + EL ++ AE ++ L E + L+ + Q Sbjct: 1653 EEAEREARRRGKAEE-QAVRQRELAEQ-ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQ 1710 Query: 2728 VRDHLAEAKEKLSILEKEDETEVQ-----ESKKACMFEPLPIKLSKSIASQTDGTLKISS 2782 +E+L+ L++E Q E++ A + + + L+ ++ + S+ Sbjct: 1711 GEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR---ST 1767 Query: 2783 SNQTPQILVKNAGIQINLQSECSS----EEVTEIISQFTEKIEKMQELHAAEILDMESRH 2838 S ++ Q L AG L E + E + Q E+ Q A +L + Sbjct: 1768 SEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAA 1827 Query: 2839 ISETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREI------ 2892 I E LK E +A LKE + E + LA +A+Q R + Sbjct: 1828 IGEATRLKTEAEIA---LKE------------KEAENERLRRLAEDEAFQRRRLEEQAAQ 1872 Query: 2893 -------------CSSDSGSDWGQGIY--------------LTHSQGFDIASEGRGEES- 2924 +SDS + +G+ L F+ A+ G+ E Sbjct: 1873 HKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELEL 1932 Query: 2925 ------ESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVS--EPWLEER 2976 +A D+ K + L A Q+ + E + E+ + ++ E +R Sbjct: 1933 ELGRIRSNAEDTLRSKEQAELEAARQR--QLAAEEERRRREAEERVQKSLAAEEEAARQR 1990 Query: 2977 KAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLA--------------- 3021 KA + + LK + + + RE +S++ + + + L A Sbjct: 1991 KAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQE 2050 Query: 3022 LQQVFLEERSVL------------------LAAFRTELTALGTTDAVGLLNCLEQRIQEQ 3063 LQQ +E+SVL A + E A + V L+Q +EQ Sbjct: 2051 LQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQ 2110 Query: 3064 G---VEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQ 3120 + QAA E L+K + QA A + ++ ++ +K +++ L Q Sbjct: 2111 AQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQV 2170 Query: 3121 KQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKE 3180 +Q ++ ++++L + L E+L K E + +Q + EL +++ Q + L + Sbjct: 2171 EQ-ELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEEL-FSVRVQMEELSK 2228 Query: 3181 LEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEK---------EKAKLGRSEERDK 3231 L+A R+E +++ + ++T Q+++ +++ E+ E A+L + E D Sbjct: 2229 LKA-RIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDL 2287 Query: 3232 EELEDLKFSLESQKQRNLQLNL-------LLEQQKQLLNESQQKIESQRMLYDAQLSEE- 3283 + L + +K + +Q LL+QQK+L E ++++ + QL+EE Sbjct: 2288 AQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEET 2347 Query: 3284 QG----------RNLELQVLLESEKVRIREMSSTLDR-ERELHAQLQSSDGTGQS--RPP 3330 QG R LE+ E K+R+ EMS R E + + ++ G+ R Sbjct: 2348 QGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTE 2407 Query: 3331 LPSEDLLK-----ELQKQ-----LEEKHSRIVELLNETEKY---------KLDSLQTRQQ 3371 L +++ + E+Q+Q E I EL E EK K + +QT QQ Sbjct: 2408 LATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQ 2467 Query: 3372 ME--KDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDL--------QRQLEEKRQQVYKL 3421 + ++ Q +++ +E+++ + ++ + + ++K+E L Q+ EE+++Q ++ Sbjct: 2468 EQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQM 2527 Query: 3422 DLEGQRLQGIMQEFQKQELEREEKRESRRILYQNLNE 3458 + E QRL M+E ++++ E EE ++ Q L + Sbjct: 2528 EQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQ 2564 Score = 147 bits (370), Expect = 3e-34 Identities = 322/1585 (20%), Positives = 651/1585 (41%), Gaps = 255/1585 (16%) Query: 1858 LEAISETSSQLEHAKVTQTELMRESFRQKQEATESLK--------CQEELRERLHEESRA 1909 L+ Q++ + ++ +RE RQ+Q E ++ CQ ++ ++ Sbjct: 1209 LQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY 1268 Query: 1910 REQLAVELSK----------------AEGVIDGYADEKT-------LFERQIQEKTDIID 1946 QL ++ +E VI Y D +T L + I+ ++ + Sbjct: 1269 ELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLR 1328 Query: 1947 RLEQELLCASN-------RLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETE 1999 R+E+E A RL E+EA ++ ++ E ++ K + EA ++Q++ +E Sbjct: 1329 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1388 Query: 2000 KLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEK---NTELMDLRQQNQ 2056 + + ++ Q Q ++++LQ+ ++ E +++ + + E+ + E+ +R Q + Sbjct: 1389 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE 1448 Query: 2057 ALEKQ---LEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQ 2113 A E+Q E + L +A + E ++ Q+E ++L +Q+ Q S+ + + + Sbjct: 1449 ATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQV------QDESQRKRQAEVE 1502 Query: 2114 LANHLKEKTDKCSE---LLLSKEQLQRDIQERNEEIEKLEF-RVRELEQALLVEDRKHFG 2169 LA+ +K + + E L + E+L+ +E + + E R R+++ AL R Sbjct: 1503 LASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA 1562 Query: 2170 AVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLE---QFREELENKNEEVQQLHMQLE 2226 +++K E Q ER ++ + + L E+ E Q + E E EE ++ + + Sbjct: 1563 ELQSKRASFAEKTAQLER-SLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ 1621 Query: 2227 IQKKESTT-RLQ--ELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKE 2283 ++ E+ RLQ E+ Q+ L + + EK KE + + GK +E+ Sbjct: 1622 LKANEALRLRLQAEEVAQQKSLAQAEAEKQ----KEEAEREARRR----GK----AEEQA 1669 Query: 2284 VEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQ 2343 V +L EQ + Q+QL T + + + ELIR L ++ E E++ + Sbjct: 1670 VRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR--------LRAETE----QGEQQRQL 1717 Query: 2344 LNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTF 2403 L E + +LQ+E A QK L E ++ +++V++A K E++ + +E+ Sbjct: 1718 LEEELARLQREAAAATQKRQ----ELEAELAKVRAEMEVLLASKARAEEESRSTSEKS-- 1771 Query: 2404 MKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVN--------------VAIDH 2449 K L+ + +L +E L+ E ++ + + E AI Sbjct: 1772 -KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGE 1830 Query: 2450 LSKDKPELEVVLTE-----DALKSLENQTYF--KSFEENGKGSIINLETRLLQLESTVSA 2502 ++ K E E+ L E + L+ L F + EE ++E RL QL A Sbjct: 1831 ATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRK---A 1887 Query: 2503 KDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKF 2562 D EL + ++D Q + ++++I+ L+ E+ A +++L ++ A+ Sbjct: 1888 SDSELERQKGLVEDTLRQRR----QVEEEILALKASFEKAAAGKAELELELGRIRSNAE- 1942 Query: 2563 CQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVE 2622 T+ S+ + L R+ +L ++ R E E +V + SL E+E Sbjct: 1943 ----DTLRSKEQA----ELEAARQRQLAAEEER---RRREAEERVQK---SLAAEEEAAR 1988 Query: 2623 IAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNE 2682 K LE+ ++L K ++ RE+ ++ S + +++ + + Sbjct: 1989 -QRKAALEEVERL----KAKVEEARRLRERAEQESARQLQLAQEAAQ------------- 2030 Query: 2683 LEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSIL 2742 + L+AE KA + ++K ++LQ+ L +++ + L+ + R EA+E Sbjct: 2031 -KRLQAEE---KAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQA 2086 Query: 2743 EKE---DETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQIN 2799 E+E +V+E+++ + + + K + + + A ++ Sbjct: 2087 EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK 2146 Query: 2800 LQSECSSEEVTEIISQ-FTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLLKE 2858 ++ E+ + Q +K + QEL + + ET+ K LL E Sbjct: 2147 QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRL------QLEETDHQKN-------LLDE 2193 Query: 2859 ECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIASE 2918 E LKA +++ S + E S Q E+ + I +E Sbjct: 2194 ELQRLKAEAT-EAARQRSQVEEELFSVRVQMEELSKLKAR----------------IEAE 2236 Query: 2919 GRGE--ESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEER 2976 R + T F ++ ++ V E ++ + E ++Q++E L ++ Sbjct: 2237 NRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQ------EAARLRQLAEEDLAQQ 2290 Query: 2977 KAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAA 3036 +A K L KMQ +EA + LL Q+ +E++ L Sbjct: 2291 RALAE-----KMLKEKMQAVQEATRLKAEAE-----------LLQQQKELAQEQARRLQE 2334 Query: 3037 FRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGR 3096 + ++ + G LE Q Q +E A E L+ R + +S QA A+ + + Sbjct: 2335 DKEQMAQQLAEETQGFQRTLEAERQRQ-LEMSAEAERLKL--RVAEMSRAQA-RAEEDAQ 2390 Query: 3097 KITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAEL 3156 + + E+ EK + E Q+K + + ++++ A L+E +AEL Sbjct: 2391 RFRKQAEEIGEKLHRT--ELATQEKVTLVQTLEIQRQQSDHDAERLRE-------AIAEL 2441 Query: 3157 KSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWAL 3216 + E + KL+ E L LK E ++ + E L + SE+ + + + Sbjct: 2442 ERE--KEKLQQEAKLL----QLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFI 2495 Query: 3217 EKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLY 3276 E+EKAKL + + + + + L+ + Q+Q+ +EQ++Q L S + E++R + Sbjct: 2496 EQEKAKLEQLFQDEVAKAQQLREEQQRQQQQ-------MEQERQRLVASME--EARRRQH 2546 Query: 3277 DAQ----LSEEQGRNLELQ-----VLLESEKVRIREMSSTLDRERE---LHAQLQSSDGT 3324 +A+ +E+ + LE Q LL E R+RE L+ + H++ ++ Sbjct: 2547 EAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQV 2606 Query: 3325 GQSRPPLPSEDLLKELQKQLEEKHS 3349 ++ D L + E +HS Sbjct: 2607 AATKTLPNGRDALDGPAAEAEPEHS 2631 Score = 141 bits (356), Expect = 1e-32 Identities = 365/1881 (19%), Positives = 749/1881 (39%), Gaps = 298/1881 (15%) Query: 417 DIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALR 476 DI ++E R + +LR LD+ ++ Q + Q AQ E+E + Sbjct: 977 DIRLQLEACETRTVHRLRLPLDKEPARECAQ---RIAEQQKAQ---------AEVEGLGK 1024 Query: 477 SYSNITVNEDQIKLM---NVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQ---RQL 530 + ++ +++ + + A L +L+ T + E+++ + LE+ + R Sbjct: 1025 GVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGT 1084 Query: 531 EDLVEELSFSREQIQRARQ---TIAEQES------KLN-EAHKSLSTVEDLKAEIVSASE 580 + E L EQ++ A+ T+ E E+ KL +A T + L+ E+ A E Sbjct: 1085 QGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQE 1144 Query: 581 SRKELELKH---EAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEEL 637 + L+ +H + EV ++ ++ L + AVL + + ++ ELE+L QL + E Sbjct: 1145 VGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQ-TDVRQRELEQLGRQLRYYRESAD 1203 Query: 638 ---SKLKEDLEIEHRINIEKLKDNLGIHYK-QQIDGLQNEMS---QKIETMQ-FEKDNLI 689 + L++ + +I L D+ + + +Q L E+ +K+E Q F K + Sbjct: 1204 PLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYIN 1263 Query: 690 TKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQE----V 745 ++ + ++ L+ +K ++ + +E LR E TL + + Sbjct: 1264 AIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFI 1323 Query: 746 QELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIF 805 E + E E+ +++ + +E+ A++EA L+ +++ E + +E + Sbjct: 1324 SETLRRMEEEERLAEQQRAEERERLAEVEAA---LEKQRQLAEAHAQAKAQAEREAK--- 1377 Query: 806 LDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQ 865 ++ + ++ V +E E D +QQ + EE+++ R + +E + ++ + Sbjct: 1378 --ELQQRMQEEVVRRE-----EAAVDAQQQKRSIQEELQQLRQS---SEAEIQAKARQAE 1427 Query: 866 EEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVA 925 L++++++ + + E + + A E LQ + + + A Sbjct: 1428 AAERSRLRIEEEIRVVRLQLEATERQRGGAEGE---LQALRARAEEAE-----------A 1473 Query: 926 ETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQ 985 + + E E+ ++ ++ + ++ ++EL+ R+ +E ++K + L E L+ Sbjct: 1474 QKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE----LRL 1529 Query: 986 EKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEE 1045 + E+ R R+ E+ RA VQ + R AE + SF E+ Sbjct: 1530 QAEEAERRLRQAEV----ERARQVQVA-----------LETAQRSAEAELQSKRASFAEK 1574 Query: 1046 SKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSE 1105 + + E S QE+ + + + +E+ RA Q +E ++ ++E +E Sbjct: 1575 TAQL-------------ERSLQEEHVA--VAQLREEAERRAQQQAEAERAREE-----AE 1614 Query: 1106 QNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIH 1165 + R Q++A + + V Q + + E +K +EE +E ++ Sbjct: 1615 RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQ-----------KEEAEREARRRG 1663 Query: 1166 QLELQTMKTQETGDEG--KPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVN 1223 + E Q ++ +E ++ K L G Q+ ++ E L+ E Sbjct: 1664 KAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELI--------------RLRAETE 1709 Query: 1224 AEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQ 1283 +++ + E E LQ ++ + L KV E LL SK + Sbjct: 1710 QGEQQRQ---LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLA-----SKARAE 1761 Query: 1284 QTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQEL 1343 + E ++ L E F + + L + K + + L + Q E Sbjct: 1762 EESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ----RQLAEEDAARQRAEA 1817 Query: 1344 ESLISSLQQQLKE-TEQNYEAEIHCLQK-----RLQAVSESTVPPSLPVDSVVIT-ESDA 1396 E +++ + E T EAEI +K RL+ ++E ++ ++D Sbjct: 1818 ERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI 1877 Query: 1397 QRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFA 1456 + + + ++K D +E + G+ E+T + + Q+EEE+ + S A A Sbjct: 1878 EERL---AQLRKASDSELE--RQKGLVEDT-------LRQRRQVEEEILALKASFEKAAA 1925 Query: 1457 QQTELS----RISGGKENTASSK---------QAHAVCQQEQHY------------FNEM 1491 + EL RI E+T SK Q ++E+ E Sbjct: 1926 GKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 1985 Query: 1492 KLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDI--PESKDCVLTIS 1549 Q + + E + K +E + + E +++ L+ E K + Sbjct: 1986 AARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQ 2045 Query: 1550 EEMFSKDKTFIVRQSIHDEISVSSMDASR--------QLMLNEEQLEDMRQ----ELVRQ 1597 ++ +T QS+ D++ + A R ++ E + RQ E ++Q Sbjct: 2046 QKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQ 2105 Query: 1598 YQEHQQATELLRQAHMRQMERQREDQ--EQLQEEIKRLNRQLAQRSSIDNENLVSE---R 1652 E Q QA ++ ++ E + + Q E L ++ A + ++ +E R Sbjct: 2106 SAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLR 2165 Query: 1653 ERVLLE-ELEALK-QLSLAGREK--LCCELRNSSTQTQNGNENQGEVEEQTFKEKELDRK 1708 ++ +E EL L+ QL +K L EL+ + + +VEE+ F + + Sbjct: 2166 QKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE 2225 Query: 1709 PEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSAS 1768 + I + R + + + + L E + V E R S +Q +A Sbjct: 2226 LSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAAR-------LSVAAQEAAR 2278 Query: 1769 LIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRS 1828 L +E + + + + E+ + +++ + + +++ ++ EL+Q R Sbjct: 2279 LRQLAEEDLAQQRALAEKMLKEKMQAVQEATR-------LKAEAELLQQQKELAQEQAR- 2330 Query: 1829 GFAGTEIDPENEELMLNISSRLQAAVEKLLEAIS----ETSSQLEHAKVTQTELMRESFR 1884 + + E++ ++ Q ++ LEA E S++ E K+ E+ R R Sbjct: 2331 -----RLQEDKEQMAQQLAEETQG-FQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQAR 2384 Query: 1885 QKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDI 1944 +++A K EE+ E+LH A ++ + E Q Q+ Sbjct: 2385 AEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT--------------LEIQRQQSDHD 2430 Query: 1945 IDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKE 2004 +RL + + ELE E++++Q+E +LL + E M+ ++QLLQET+ L + Sbjct: 2431 AERLREAIA-------ELEREKEKLQQEAKLLQLKSEEMQTVQ---QEQLLQETQALQQS 2480 Query: 2005 KLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEK 2064 L +D L ++ E +E++ ++ +L Q++ + LR++ Q ++Q+E+ Sbjct: 2481 FL-------SEKDSLLQR----ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2529 Query: 2065 MRKFL---DEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEK 2121 R+ L E+A R+HE + + Q+ QQL E Q R+ E+L L E+ Sbjct: 2530 ERQRLVASMEEARRRQHEAEEGVRRKQEELQQL----------EQQRRQQEEL---LAEE 2576 Query: 2122 TDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVEDRKHFGAVEAKPELSLEV 2181 + E L E+ R +EE+ + V + D A EA+PE S + Sbjct: 2577 NQRLREQLQLLEEQHRAALAHSEEVTASQ--VAATKTLPNGRDALDGPAAEAEPEHSFD- 2633 Query: 2182 QLQAERDAIDRKEKEITNLEE 2202 L+ + A +E I + EE Sbjct: 2634 GLRRKVSAQRLQEAGILSAEE 2654 Score = 139 bits (349), Expect = 7e-32 Identities = 361/1895 (19%), Positives = 769/1895 (40%), Gaps = 224/1895 (11%) Query: 424 QETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITV 483 QE +LE L ++ Q V MK L Q + + ++ +RS+S T Sbjct: 852 QEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQL-----------IRSWSLATF 900 Query: 484 NEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQ 543 + + A++ L + Q + + G E++ +R+ S +Q Sbjct: 901 RTLKPEEQRQALHSLELHYQAFLRDSQ---DAGGFGPEDRLMAEREYGSC----SHHYQQ 953 Query: 544 IQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEML 603 + ++ + A++ES+ + +S ++D++ ++ A E+R T ++++L + Sbjct: 954 LLQSLEQGAQEESR---CQRCISELKDIRLQL-EACETR-----------TVHRLRLPLD 998 Query: 604 EKEKNAVLDRMAESQ--EAELERLRTQL--LFSHEEELSKLKEDLEIEHRINIEKLKDNL 659 ++ R+AE Q +AE+E L + L + E++ L E + E L Sbjct: 999 KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSEL---EL 1055 Query: 660 GIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQ--------SLVN 711 + +Q+ L +K++T+ + L +LK+ Q Sbjct: 1056 TLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATK 1115 Query: 712 SKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFA 771 + +++ Q Q + LR E + + + +Q+ + ++ ++ +E+ L E++ Sbjct: 1116 ASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQ 1175 Query: 772 QLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEIL-IEENE 830 + A+ + + E + L L+ + S + +L + + +++I+ + + +++ Sbjct: 1176 AVLAQTDVRQRELEQLGRQLRYYRE-SADPLGAWLQDARRR------QEQIQAMPLADSQ 1228 Query: 831 DLKQQCIQ---LNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQEL 887 +++Q Q L EEIE+ ++ + +++ L+ K LE + + Sbjct: 1229 AVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAK- 1287 Query: 888 EYKSKLKALNEELHLQRINPTTVKMK-SSVFDEDKTFVAETLEMGEVVEKDTTELMEKLE 946 K K+++ +E + + ++ T + +++ + F++ETL E E+ L E+ Sbjct: 1288 --KPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER----LAEQQR 1341 Query: 947 VTKREKLELSQRLSDLSEQLKQKHGEISFLNE-EVKSLKQEKEQVSLRCRELEIIINHNR 1005 +RE+L + + QL + H + E E K L+Q ++ +R RE + + Sbjct: 1342 AEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR-REEAAVDAQQQ 1400 Query: 1006 AENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEES 1065 ++Q Q+ + + +R AE + E S++ +E+++ + + Sbjct: 1401 KRSIQEELQQLRQSSEAEIQAKARQAEAA---------ERSRLRIEEEIRVVRLQLEATE 1451 Query: 1066 KQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYS 1125 +Q L +LRA +E + QK ++E+ ++Q E+QR + V Sbjct: 1452 RQRGGAEGEL------QALRAR--AEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVEL 1503 Query: 1126 THVDQVREYMENEKDKALCSLKEELIFAQEEKIK----ELQKIHQLELQTMKTQETGDEG 1181 + EK +AL +L+E + A+E + + E+++ Q+++ Q + + Sbjct: 1504 ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE-- 1561 Query: 1182 KPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPE 1241 +LQ + Q S+ E+ A E + + E+ E Sbjct: 1562 -------AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAE 1614 Query: 1242 LQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEE 1301 + R++++ + L + + L + K ++ + + E+ + + E Sbjct: 1615 RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRE 1674 Query: 1302 TEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNY 1361 + Q E + +L++ Q+L + + E + E + + L+++L ++ Sbjct: 1675 LAEQELEKQRQLAEG---TAQQRLAAEQELIRLRAETEQGEQQRQL--LEEELARLQREA 1729 Query: 1362 EAEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFG 1421 A QKR + +E + + V+ S A+ S +K+ +G F Sbjct: 1730 AA---ATQKRQELEAELA---KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFR 1783 Query: 1422 -VKEETNIVKLL--EKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAH 1478 + EE ++ L E + Q QL EE A + A A++ +++ E T +A Sbjct: 1784 ELAEEAARLRALAEEAKRQRQLAEEDA----ARQRAEAERVLAEKLAAIGEATRLKTEAE 1839 Query: 1479 AVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDI 1538 ++++ ++ + FQ + L ++ +H DI Sbjct: 1840 IALKEKEAENERLRRLAEDEAFQR------------RRLEEQAAQHKA----------DI 1877 Query: 1539 PESKDCVLTISEEMFSKDKTFI---VRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELV 1595 E + S+ + K + +RQ E + ++ AS + + ++ + Sbjct: 1878 EERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRI 1937 Query: 1596 RQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERV 1655 R A + LR ++E R+ Q +EE +R + + S+ E + + + Sbjct: 1938 RS-----NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA 1992 Query: 1656 LLEELEALKQLSLAGREKLCCELRNSSTQTQNGNEN-----QGEVEEQTF----KEKELD 1706 LEE+E LK R + S+ Q Q E Q E + F KE+EL Sbjct: 1993 ALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQ 2052 Query: 1707 R--KPEDVPPEILSNE----RYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRS 1760 + + E + L E R A ++A ++ E ++ VEE L +S Sbjct: 2053 QTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER------LKQS 2106 Query: 1761 SKSQSSASLIWRSEAEASVKSCVHEEHTRVTDE--SIPSYSGSDMPRNDINMWSKVT-EE 1817 ++ Q+ A ++ AE K E R E ++ +D +++ T + Sbjct: 2107 AEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ 2166 Query: 1818 GTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTE 1877 ++ Q L E D + + L+ RL+A + S+ +L +V E Sbjct: 2167 KAQVEQELTTLRLQLEETDHQ-KNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE 2225 Query: 1878 LMRESFR-QKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFER 1936 L + R + + L+ ++ + L EE+ +Q+A E ++ A + L E Sbjct: 2226 LSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE 2285 Query: 1937 QIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQ 1996 + ++ + +++ +E + A L+AE + +Q+++EL Q ++ + + QQL + Sbjct: 2286 DLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAE 2345 Query: 1997 ETEKLMK-------EKLEVQCQAEKVR--------------DDLQKQVKALEIDVEEQVS 2035 ET+ + +LE+ +AE+++ +D Q+ K E ++ E++ Sbjct: 2346 ETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE-EIGEKLH 2404 Query: 2036 RFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLK 2095 R QEK T + L Q Q + E++R+ + E E E++ QQE + L QLK Sbjct: 2405 RTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAEL----EREKEKLQQEAKLL--QLK 2458 Query: 2096 VVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKE----QLQRDIQERNEEIEKL-- 2149 E QT + EQL ++T + LS++ Q +R I++ ++E+L Sbjct: 2459 S-------EEMQTVQQEQLL----QETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQ 2507 Query: 2150 -----EFRVRELEQALLVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQL 2204 ++RE +Q + + + A E + Q +AE + + RK++E+ LE+Q Sbjct: 2508 DEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAE-EGVRRKQEELQQLEQQR 2566 Query: 2205 EQFREELENKNEEVQQLHMQLEIQKKESTTRLQEL 2239 Q E L +N+ +++ LE Q + + +E+ Sbjct: 2567 RQQEELLAEENQRLREQLQLLEEQHRAALAHSEEV 2601 Score = 125 bits (315), Expect = 6e-28 Identities = 335/1644 (20%), Positives = 647/1644 (39%), Gaps = 231/1644 (14%) Query: 2109 REVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEF-RVRELEQALLVEDRKH 2167 RE ++H ++ + + + QR I E + +LE R + + L D++ Sbjct: 942 REYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEP 1001 Query: 2168 FGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEI 2227 A E ++ + + QAE + + K + L + E+ L + L +LE+ Sbjct: 1002 --ARECAQRIAEQQKAQAEVEGLG---KGVARLSAEAEKVLA-LPEPSPAAPTLRSELEL 1055 Query: 2228 QKKESTTRLQELEQENKLFKDDMEKLGLAIKESD-AMSTQDQHVLFGKFAQIIQEKEVEI 2286 + +L+++ + ++ + ++ + L I+ + A H K AQ + E+ Sbjct: 1056 ----TLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPEL 1111 Query: 2287 DQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNE 2346 + + KL+ Q + + + +R + E L R+ E+E+ E Sbjct: 1112 EATKASLKKLRAQAE--AQQPTFDALRDELRGAQEVGERLQQRHG----ERDVEVERWRE 1165 Query: 2347 VIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKL-ALEQQVETANEEMTFMK 2405 + +L + + +T + L + L++ + A+ L A Q E++ M Sbjct: 1166 RVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRES--ADPLGAWLQDARRRQEQIQAMP 1223 Query: 2406 NVLKETNFKMNQLTQE---LFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLT 2462 L ++ QL QE L ++R E VE+ Q + +N D+ EL++V Sbjct: 1224 --LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY------ELQLVTY 1275 Query: 2463 EDALKSLENQTYFKSFEENGKGSII----NLETRLLQLESTVSAKDLELTQCYKQIKDMQ 2518 + L+ + + K ++G S+I +L T +L + S +++ +++++ + Sbjct: 1276 KAQLEPVASPAK-KPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEE 1334 Query: 2519 EQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNI 2578 + Q++ +++ E V AAL Q QL AK +E E + Sbjct: 1335 RLAE------QQRAEERERLAE--VEAALEKQRQLAEAHAQAK-------AQAEREAKEL 1379 Query: 2579 QNLNQ---LREDELGSDISALTLRISELESQVVEMHTSLILEK-EQVEIAEKNVLEKEKK 2634 Q Q +R +E D I E Q+ + + I K Q E AE++ L E++ Sbjct: 1380 QQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEE 1439 Query: 2635 LLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATK 2694 + ++ LE E+++ G EL+ALRA + + Sbjct: 1440 IRVVRLQLEATERQR---------------------------GGAEGELQALRARAEEAE 1472 Query: 2695 AELASYKEKAEKLQEELLVKETNMTSLQKDL-SQVRDHLAEAKEKLSILEKEDETEVQES 2753 A+ +E+AE+L+ ++ + + +L S+V+ A+EK L+ +E +Q Sbjct: 1473 AQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAE 1532 Query: 2754 KKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGI-QINLQSECSSEEVTEI 2812 + ++ ++ Q L+ + + ++ K A + Q E S +E Sbjct: 1533 EAERRLRQAEVERAR----QVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVA 1588 Query: 2813 ISQFTEKIEKMQELHA-AEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLR 2871 ++Q E+ E+ + A AE E+ E LK + ++L EE K++ Q Sbjct: 1589 VAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEA 1648 Query: 2872 SKEGSSIPE------LAHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESE 2925 K+ A A + RE+ + +EG ++ Sbjct: 1649 EKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ-------------LAEGTAQQRL 1695 Query: 2926 SATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSI-----QQVSEPWLEERKAYI 2980 +A + LRA +G Q L E + + + +Q E L + +A + Sbjct: 1696 AAEQELIR-----LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEM 1750 Query: 2981 NTISSLK--------DLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSV 3032 + + K K + + EAE + E + R A +Q L E Sbjct: 1751 EVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDA 1810 Query: 3033 LLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQK-----ADRRSLLSEIQ 3087 E A+G L+ + E +A E L++ A +R L E Sbjct: 1811 ARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA 1870 Query: 3088 ALH-AQMNGRKITLKREQESEKPSQE-LLEYNIQQKQSQMLEMQVELSSMKDRATELQEQ 3145 A H A + R L++ +SE Q+ L+E ++Q++ +++ E+ ++K Sbjct: 1871 AQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRR----QVEEEILALK--------- 1917 Query: 3146 LSSEKMVV--AELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLA 3203 S EK AEL+ EL + + E TL++ K ELEA R A Sbjct: 1918 ASFEKAAAGKAELELELGRIRSNAEDTLRS--KEQAELEAARQR------------QLAA 1963 Query: 3204 SEQKKSRELQWALEKEKA---KLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQ 3260 E+++ RE + ++K A + R + EE+E LK +E ++ + +Q Q Sbjct: 1964 EEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQ 2023 Query: 3261 LLNESQQK---IESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDREREL--- 3314 L E+ QK E + + Q E+ ELQ L+ E+ + ++ + R Sbjct: 2024 LAQEAAQKRLQAEEKAHAFAVQQKEQ-----ELQQTLQQEQSVLDQLRGEAEAARRAAEE 2078 Query: 3315 --HAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIV----ELLNETEKYKLDSLQT 3368 A++Q+ QSR + + LK+ ++ + ++ +L E E+ Q Sbjct: 2079 AEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQA 2138 Query: 3369 RQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRL 3428 Q + +Q ++ ++ + ++ +++ ++ L+ QLEE Q LD E QRL Sbjct: 2139 EQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRL 2198 Query: 3429 QGIMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYA 3488 + E +Q + EE+ S R+ + L++ L+ +IE E + Sbjct: 2199 KAEATEAARQRSQVEEELFSVRVQMEELSK---------------LKARIEAENR----- 2238 Query: 3489 KLIEMNGGGTGCNHELEMIRQKLQCVASKLQVLPQKASERLQFETADDEDFIWVQENIDE 3548 LI + T L+ +K++ VA + L A E + +ED + Q + E Sbjct: 2239 ALILRDKDNT--QRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED-LAQQRALAE 2295 Query: 3549 IILQLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKL 3608 +L+ E+ V +T + E LL+Q EL ++ +E D M +L Sbjct: 2296 KMLK---------EKMQAVQEATRLKAEAE-LLQQQKELAQEQARRLQE--DKEQMAQQL 2343 Query: 3609 EEQIRWYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRAE--AEVY 3666 E+ + +++T L + +++E E + ++ RAE A+ + Sbjct: 2344 AEETQGFQRT-----------LEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRF 2392 Query: 3667 KLKAELRNDSLLQTLSPDSEHVTL 3690 + +AE + L +T E VTL Sbjct: 2393 RKQAEEIGEKLHRTELATQEKVTL 2416 Score = 48.5 bits (114), Expect = 1e-04 Identities = 142/683 (20%), Positives = 274/683 (40%), Gaps = 64/683 (9%) Query: 3052 LLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNG---RKITLKREQESEK 3108 LL LEQ QE+ C + +SE++ + Q+ R + R ++ Sbjct: 954 LLQSLEQGAQEES-------RC------QRCISELKDIRLQLEACETRTVHRLRLPLDKE 1000 Query: 3109 PSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQT-KLEL 3167 P++E + +Q+++Q E+ + L + +EK++ S A T + EL Sbjct: 1001 PARECAQRIAEQQKAQ-----AEVEGLGKGVARLSAE--AEKVLALPEPSPAAPTLRSEL 1053 Query: 3168 ETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSE 3227 E TL + + ++ L A LE K KT + + A E ++ E Q + Sbjct: 1054 ELTL-GKLEQVRSLSAIYLE-KLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPEL 1111 Query: 3228 ERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRN 3287 E K L+ L+ E+Q+ L L +++ QQ+ +R + + E + Sbjct: 1112 EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQR-HGERDVEVERWRERVAQL 1170 Query: 3288 LEL-QVLLESEKVRIREMSST---LDRERE----LHAQLQSSDGTGQSRPPLPSEDLLKE 3339 LE Q +L VR RE+ L RE L A LQ + + +P D + Sbjct: 1171 LERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADS-QA 1229 Query: 3340 LQKQLEEKHSRIVELLNETEKYKLDSLQTRQQME--KDRQVHRKTLQTEQEANTEGQKKM 3397 +++QL ++ + + E+ EK + +Q + KD ++ T + + E KK Sbjct: 1230 VREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKP 1289 Query: 3398 HELQSKVEDLQRQLEEKRQQVYKLD-LEGQRLQGIMQEFQKQELEREEKRESRRILYQNL 3456 ++QS E + ++ + R +L L Q ++ I + ++ E E + R + L Sbjct: 1290 -KVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERL 1348 Query: 3457 NEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMI--RQKLQCV 3514 E +L R + + + + + AK ++ E + +Q+ + + Sbjct: 1349 AEVEA-ALEKQRQ---LAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSI 1404 Query: 3515 ASKLQVLPQKASERLQFET----ADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSPS 3570 +LQ L Q + +Q + A + + ++E I + LQL+ Q+G + Sbjct: 1405 QEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL 1464 Query: 3571 TSCGSLTERLLRQNAELTGHIS-QLTEEKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRFS 3629 + E RQ E + Q+ +E R ++L +++ + A R+ Sbjct: 1465 RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVK--AEAEAAREKQRALQ 1522 Query: 3630 LNGGANIEAIIA------SEKEVWNREKLTLQKSLKRAEAEVYKLKAELRNDSLLQTLSP 3683 ++A A +E E + ++ L+ + + AEAE+ +A + S Sbjct: 1523 ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1582 Query: 3684 DSEHVTLKRIYGKYLRAESFRKA 3706 EHV + + LR E+ R+A Sbjct: 1583 QEEHVAVAQ-----LREEAERRA 1600 Score = 35.8 bits (81), Expect = 0.85 Identities = 52/235 (22%), Positives = 101/235 (42%), Gaps = 31/235 (13%) Query: 2138 DIQE--RNEEIEKLEFRVRELEQALLVEDRKHFGAVEAK--PELSLEVQLQAERDAIDRK 2193 D+Q+ R E++ REL LL R H A E + P E+++ + + K Sbjct: 253 DVQDGVRANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQ-FLKFK 311 Query: 2194 EKEITNLEEQLEQFREELENKNEEVQQLHMQ-------LEIQKKESTTRLQELEQENKLF 2246 E E+ E + + ++ VQ ++ L+++K+ + LE+E +L Sbjct: 312 EMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQL- 370 Query: 2247 KDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDN 2306 + + E+L Q ++ ++ E + +QLN+ LQ +++ Sbjct: 371 RSEFERLECL-----------QRIV----TKLQMEAGLCEEQLNQADALLQSDVRLLAAG 415 Query: 2307 KVIEEKNELIRDL---ETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANI 2358 KV + E+ RDL ++ I L +D + +K R + EQ+ + +L + L I Sbjct: 416 KVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAI 470 Score = 35.8 bits (81), Expect = 0.85 Identities = 60/292 (20%), Positives = 111/292 (38%), Gaps = 39/292 (13%) Query: 4 EERQKKLEAGKAKLAQFR-------QRKAQSDGQ-----SPSKKQKKKRKTSSSKHDVSA 51 +E+ ++L+ K ++AQ QR +++ Q S ++ K R S+ A Sbjct: 2326 QEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA 2385 Query: 52 HHDLNIDQSQCNEMYINSSQRVESTVIPESTIMRTLH-SGEITSHEQGFSVELESEISTT 110 D + Q E+ R E + T+++TL + + H+ E +E+ Sbjct: 2386 EEDAQRFRKQAEEIG-EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELERE 2444 Query: 111 ADDCSSEVNGCSFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHE 170 + E K L EE V Q Q + L ++ Sbjct: 2445 KEKLQQEA----------KLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERF 2494 Query: 171 IEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLE 230 IE+ +LE++ + Q +E + +Q + +L A++++ARR + E Sbjct: 2495 IEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRR 2554 Query: 231 LTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDH 282 E+ Q+L+ Q +Q + +LL + Q L Q QL E+ H Sbjct: 2555 KQEELQQLEQQRRQQE---------------ELLAEENQRLREQLQLLEEQH 2591 >gi|47607492 plectin 1 isoform 1 [Homo sapiens] Length = 4574 Score = 192 bits (487), Expect = 7e-48 Identities = 274/1260 (21%), Positives = 544/1260 (43%), Gaps = 171/1260 (13%) Query: 1579 QLMLNEEQLEDMRQE---LVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNR 1635 +++ EE D +Q+ + + Q+ +Q++E QA RQ E + +++EEI+ + Sbjct: 1427 EVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRL 1486 Query: 1636 QLA----QRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNEN 1691 QL QR + E + R EE EA K+ + E+L ++++ S Q + Sbjct: 1487 QLEATERQRGGAEGE---LQALRARAEEAEAQKRQAQEEAERLRRQVQDES---QRKRQA 1540 Query: 1692 QGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGR 1751 + E+ + E E R+ + + L R ++A RL + +E + ET Sbjct: 1541 EVELASRVKAEAEAAREKQRAL-QALEELRLQAEEAERRLRQAEVERARQVQVALETA-- 1597 Query: 1752 HVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMW 1811 RS++++ + +E A ++ + EEH V Sbjct: 1598 ------QRSAEAELQSKRASFAEKTAQLERSLQEEHVAV--------------------- 1630 Query: 1812 SKVTEEGTELSQRLVRSGFAGTEIDPENE--ELMLNISSRLQAAVEKLLEAISETSSQLE 1869 +++ EE +Q+ + A E + E E +L N + RL+ E++ + S ++ E Sbjct: 1631 AQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE 1690 Query: 1870 HAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYAD 1929 K E RE+ R+ + ++++ +E + L ++ + E A + AE + Sbjct: 1691 KQK---EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRA 1747 Query: 1930 EKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELL------------- 1976 E E+Q Q + + RL++E A+ + QELEAE +++ E E+L Sbjct: 1748 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS 1807 Query: 1977 --SRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQV 2034 + K+ ++AEAG ++L +E +L E + Q + +D +Q E + E++ Sbjct: 1808 TSEKSKQRLEAEAGRF-RELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKL 1866 Query: 2035 SRFIE---LEQEKNTELMDLRQQNQALEKQLEK---MRKFLDEQAIDREHERDVFQQEIQ 2088 + E L+ E L + +N+ L + E R+ L+EQA +H+ D+ ++ Q Sbjct: 1867 AAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA--AQHKADIEERLAQ 1924 Query: 2089 KLEQQLKVVPRFQPISE---HQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEE 2145 + + R + + E Q R+VE+ LK +K + K +L+ ++ Sbjct: 1925 LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAA---AGKAELELELGRIRSN 1981 Query: 2146 IEKLEFRVRELEQALLVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLE 2205 E +R EQA L R+ A E + + R+A +R +K + EE Sbjct: 1982 AED---TLRSKEQAELEAARQRQLAAEEE---------RRRREAEERVQKSLAAEEEAAR 2029 Query: 2206 QFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMST 2265 Q + L EEV++L ++E ++ QE ++ +L ++ +K A +++ A + Sbjct: 2030 QRKAAL----EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAV 2085 Query: 2266 QDQHVLFGKFAQIIQEKEVEIDQLNEQV------------TKLQQQLKITTDNKVIEEKN 2313 Q + + Q +Q+++ +DQL + ++Q + + + +EE Sbjct: 2086 QQKE---QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAE 2142 Query: 2314 ELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEA 2373 L + E Q + Q ++ R+E + E + Q E A + QK + +A E Sbjct: 2143 RLKQSAEEQAQARAQAQAAAEKLRKEAEQ---EAARRAQAEQAALRQKQAADA-----EM 2194 Query: 2374 DSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVE 2433 + K + + +K +EQ E+T ++ L+ET+ + N L +EL LK E Sbjct: 2195 EKHKKFAEQTLRQKAQVEQ-------ELTTLRLQLEETDHQKNLLDEELQRLKAEATEAA 2247 Query: 2434 KIQSIPEN---SVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLE 2490 + +S E SV V ++ LSK K +E L+ +N F EE K + E Sbjct: 2248 RQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQ-EEAEKMKQVAEE 2306 Query: 2491 TRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQ 2550 L + + +A+ +L + +D+ +Q +ML++K+ +Q+ K A L+ Q Sbjct: 2307 AARLSVAAQEAARLRQLAE-----EDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQ 2361 Query: 2551 IQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQL------REDELGSDISALTLRISEL- 2603 Q E QE A+ Q+++ ++ Q + R+ E+ ++ L LR++E+ Sbjct: 2362 -QKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMS 2420 Query: 2604 -----------------ESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNE 2646 E ++H + + +E+V + + +++++ + ++L E Sbjct: 2421 RAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIA 2480 Query: 2647 KKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAEL-------AS 2699 + +REKEK + Q+ ++L+ +E + ++ E +AL+ ++ K L Sbjct: 2481 ELEREKEKLQ--QEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQ 2538 Query: 2700 YKEKAEKLQEELLVKETNMTS----LQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKK 2755 K K E+L ++ + K + Q+ + Q R L + E+ + E E V+ ++ Sbjct: 2539 EKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQE 2598 Score = 171 bits (433), Expect = 1e-41 Identities = 345/1688 (20%), Positives = 693/1688 (41%), Gaps = 223/1688 (13%) Query: 1837 PENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQ 1896 PE + S L+ + KL + S ++ LE K + R Q A E L+ Sbjct: 1081 PEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVI-----RGTQGAEEVLRAH 1135 Query: 1897 EELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCAS 1956 EE + +E AV + E + +K + + Q+ T D L EL A Sbjct: 1136 EE---------QLKEAQAVPATLPELEATKASLKKLRAQAEAQQPT--FDALRDELRGA- 1183 Query: 1957 NRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVR 2016 QE+ QQ ER++ + A+ Q +L +T+ +E ++ Q R Sbjct: 1184 ---QEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYR 1240 Query: 2017 DDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDE-QAID 2075 + L+ D + + + + + + +Q QAL +++E+ + ++E Q Sbjct: 1241 ESADPLGAWLQ-DARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFA 1299 Query: 2076 REHERDVFQQEIQKL--EQQLKVV------PRFQPISEHQTREVEQLANHLKEKTDKCSE 2127 +++ + E+Q + + QL+ V P+ Q SE +E L H E T S+ Sbjct: 1300 KQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQ 1359 Query: 2128 LL--LSKEQLQRDIQERNEEIEKLEFRVRELEQALLVEDRKHFGAVEAKPELSLEVQLQA 2185 + +S+ + + +ER E ++ E R R E +E ++ A + + QA Sbjct: 1360 YIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHA------QAKAQA 1413 Query: 2186 ERDAID---RKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQE 2242 ER+A + R ++E+ EE +++ + EE+QQL E + + + + E+ Sbjct: 1414 EREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERS 1473 Query: 2243 NKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKI 2302 ++++ + L ++ ++ + L A+ +E E + Q E+ +L++Q Sbjct: 1474 RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARA-EEAEAQKRQAQEEAERLRRQ--- 1529 Query: 2303 TTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKT 2362 ++++++ R E ++ + + R ++ ++ L E+ +LQ Sbjct: 1530 ------VQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL--RLQ---------- 1571 Query: 2363 SMNAHSLSEEADSLKHQLDVVIAEKL--ALEQQVETANEEMTFMKNVLKETNFKMNQLTQ 2420 +EEA+ Q +V A ++ ALE +A E+ + E ++ + Sbjct: 1572 -------AEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLER--- 1621 Query: 2421 ELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEE 2480 SL+ E +V +++ E + + + E E L LK+ E Sbjct: 1622 ---SLQEEHVAVAQLREEAERRAQQQAE-AERAREEAERELERWQLKANEA--------- 1668 Query: 2481 NGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQ----GQFETEMLQKKIVNLQ 2536 L RL Q E K L + KQ ++ + + G+ E + ++++ + Q Sbjct: 1669 --------LRLRL-QAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1719 Query: 2537 KIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGS---DI 2593 ++ +++ A +Q +L A QE + + +E E+ Q QL E+EL + Sbjct: 1720 ELEKQRQLAEGTAQQRLAAEQELIR-------LRAETEQGEQQR--QLLEEELARLQREA 1770 Query: 2594 SALTLRISELESQVVEMHTS---LILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQR 2650 +A T + ELE+++ ++ L+ K + E ++ EK K+ LE E ++ Sbjct: 1771 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA----EAGRFREL 1826 Query: 2651 EKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALR--AESVATKAELASYKEKAEKLQ 2708 +E R E K +L EE EA R AE +A E K +AE Sbjct: 1827 AEEAARLRALAEEAKRQRQLA---EEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIAL 1883 Query: 2709 EELLVKETNMTSLQKDLS--------QVRDHLAEAKEKLSILEKEDETEVQESK------ 2754 +E + + L +D + Q H A+ +E+L+ L K ++E++ K Sbjct: 1884 KEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDT 1943 Query: 2755 ----KACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVT 2810 + E L +K S A+ L++ I+ N + S+E Sbjct: 1944 LRQRRQVEEEILALKASFEKAAAGKAELELELGR-----------IRSNAEDTLRSKEQA 1992 Query: 2811 EIISQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCL 2870 E+ + ++ +E E + + ++ E R+ A+ EE LKA ++ Sbjct: 1993 ELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL----EEVERLKAKVEEA 2048 Query: 2871 R------SKEGSSIPELAHSDAY---QTREICSSDSGSDWGQGIYLTHSQGFDIASEGRG 2921 R +E + +LA A Q E + + Q + T Q + + RG Sbjct: 2049 RRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRG 2108 Query: 2922 EESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYIN 2981 E +E+A + A E +V + E+ S + +++ + E+ +A Sbjct: 2109 E-AEAARRA----------AEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQ 2157 Query: 2982 TISSLKDLITKMQLQ--REAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRT 3039 ++ + L + + + R A+ ++ + +D E + L +++ + T Sbjct: 2158 AQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTT 2217 Query: 3040 ELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADR-----RSLLSEIQALHAQMN 3094 L TD N L++ +Q E A + + R + E+ L A++ Sbjct: 2218 LRLQLEETDHQK--NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIE 2275 Query: 3095 G--RKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATEL---------Q 3143 R + L+ + +++ QE E K Q+ E LS A L Q Sbjct: 2276 AENRALILRDKDNTQRFLQEEAE-----KMKQVAEEAARLSVAAQEAARLRQLAEEDLAQ 2330 Query: 3144 EQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLA 3203 ++ +EKM+ ++++ T+L+ E L Q K L + +A RL+ + L +T Sbjct: 2331 QRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQG 2390 Query: 3204 S----EQKKSRELQWALEKEKAKL-----GRSEERDKEELEDLKFSLESQKQRNLQLNLL 3254 E ++ R+L+ + E E+ KL R++ R +E+ + + E ++ L L Sbjct: 2391 FQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEK-LHRTEL 2449 Query: 3255 LEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDREREL 3314 Q+K L ++ + I+ Q+ +DA+ E LE + ++ ++ ++ S + + Sbjct: 2450 ATQEKVTLVQTLE-IQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQ 2508 Query: 3315 HAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNE----TEKYKLDSLQTRQ 3370 LQ + QS L +D L + ++ +E++ +++ +L + ++ + + + +Q Sbjct: 2509 EQLLQETQALQQSF--LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQ 2566 Query: 3371 QMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQG 3430 QME++RQ + + + +EA + ++ K E+LQ+ +++RQQ L E QRL+ Sbjct: 2567 QMEQERQ---RLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLRE 2623 Query: 3431 IMQEFQKQ 3438 +Q ++Q Sbjct: 2624 QLQLLEEQ 2631 Score = 158 bits (399), Expect = 1e-37 Identities = 323/1676 (19%), Positives = 685/1676 (40%), Gaps = 242/1676 (14%) Query: 153 SPTHLEMMESELAGKQHEIEELNR-ELEEMR----VTYGTEGLQQ-LQEFEAAIKQRDGI 206 +PT +E L GK ++ L+ LE+++ V GT+G ++ L+ E +K+ + Sbjct: 1087 APTLRSELELTL-GKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAV 1145 Query: 207 ITQLT------ANLQQARREKDETMREFLELTEQ---SQKLQIQFQQLQASETLRNSTHS 257 L A+L++ R + + F L ++ +Q++ + QQ + Sbjct: 1146 PATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWR 1205 Query: 258 STAADLLQAKQQILTH----QQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQD 313 A LL+ Q +L Q++LE+ L Y++ + ++LQ+ + E Q Sbjct: 1206 ERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLG---AWLQDARRRQEQIQA 1262 Query: 314 KKVENSN--KEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQ 371 + +S +E++++++ ++EE+ +K E + + + + Q+V Sbjct: 1263 MPLADSQAVREQLRQEQALLEEIE----RHGEKVEECQRFAKQYINAIKDYELQLVTYKA 1318 Query: 372 EIKNMKLELTNSKQKERQSS--EEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRK 429 +++ + K + S +E L EL + +F ++ ++RME+E +R Sbjct: 1319 QLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEE-ERL 1377 Query: 430 LEQLRAE-----------------LDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEME 472 EQ RAE L E + Q Q ++E EE+ R + ++ Sbjct: 1378 AEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVD 1437 Query: 473 NALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKE---KLKEELGLI---LE----- 521 + S + E+ +L + E+ K + + + +++EE+ ++ LE Sbjct: 1438 AQQQKRS---IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQ 1494 Query: 522 ------EKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEI 575 E AL+ + E+ + ++E+ +R R+ + ++ + +A L++ +KAE Sbjct: 1495 RGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELAS--RVKAEA 1552 Query: 576 VSASESRKEL----ELKHEAEVTNYKIKLEMLEKEK--NAVLDRMAESQEAELERLRTQL 629 +A E ++ L EL+ +AE +++ +E+ + L+ S EAEL+ R Sbjct: 1553 EAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRA-- 1610 Query: 630 LFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDG--LQNEMSQKIETMQFEKDN 687 S E+ ++L+ L+ EH + + +L++ +QQ + + E +++E Q + + Sbjct: 1611 --SFAEKTAQLERSLQEEH-VAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANE 1667 Query: 688 LITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTL-EQEVQ 746 + + Q E+++ K L Q+ E +K+ E +E + +G EQ V+ Sbjct: 1668 ALRLRLQ-AEEVAQQKSLAQA--------------EAEKQKEEAEREARRRGKAEEQAVR 1712 Query: 747 ELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFL 806 + +L + LEKQ + E Q++ A AE +++ L+ T +++R + Sbjct: 1713 QRELAEQELEKQRQLAEGTAQQRLA---AEQELIR---------LRAETEQGEQQRQLLE 1760 Query: 807 DSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEI-----------EKQRNTFSFAEK 855 + + + ++E ++ ++L+ + ++ E+ E+ R+T +++ Sbjct: 1761 EEL------ARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQ 1814 Query: 856 NFEV---NYQELQEEYACLLKVKDD-------LEDSKNKQELEYK----SKLKALNEELH 901 E ++EL EE A L + ++ E+ +Q E + KL A+ E Sbjct: 1815 RLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATR 1874 Query: 902 LQRINPTTVKMKSSVFD------EDKTFVAETLEMGEVVEKDTTELMEKL-EVTKREKLE 954 L+ +K K + + ED+ F LE E + ++ E+L ++ K E Sbjct: 1875 LKTEAEIALKEKEAENERLRRLAEDEAFQRRRLE--EQAAQHKADIEERLAQLRKASDSE 1932 Query: 955 LSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDT 1014 L ++ + + L+Q+ + EE+ +LK E+ + ELE+ + R+ + + Sbjct: 1933 LERQKGLVEDTLRQRRQ----VEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS 1988 Query: 1015 QVSSLLDG-----VVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQ 1069 + + L+ + R + +V KS E + + K + E + + +E Sbjct: 1989 KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 2048 Query: 1070 LILDHLPSVTKESSLRATQPSENDKLQKE--LNVLKSEQNDLRLQMEAQRICLSLVYSTH 1127 L L+ Q + +LQ E + +Q + LQ Q+ + Sbjct: 2049 RRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ------EQSV 2102 Query: 1128 VDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLL 1187 +DQ+R E + +A +E + A+ E + +++ + E +E Sbjct: 2103 LDQLRGEAEAAR-RAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAA 2161 Query: 1188 IGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRY 1247 KL+K +E + Q + L + + E + + E Q R Sbjct: 2162 AEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE--------------QTLRQ 2207 Query: 1248 EVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSI 1307 + Q QE + TL ++ E ++ +L L ++ + T+ + + E E S+ Sbjct: 2208 KAQVEQE-LTTLRLQLEETDHQKNLLDEELQRLKAEATEAAR------QRSQVEEELFSV 2260 Query: 1308 HSQMTNLEDID--VNHKSKLSSLQDLEKTK--LEEQVQELESL------ISSLQQQLKET 1357 QM L + + +++ L+D + T+ L+E+ ++++ + +S Q+ Sbjct: 2261 RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARL 2320 Query: 1358 EQNYEAEI--------HCLQKRLQAVSEST---VPPSLPVDSVVITESDAQRTMYPGSCV 1406 Q E ++ L++++QAV E+T L + + A+R + Sbjct: 2321 RQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM 2380 Query: 1407 KKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISG 1466 + + +E + LE + Q QLE + + +A E+SR Sbjct: 2381 AQQL-----------AEETQGFQRTLEAERQRQLEMSAEAERLKLRVA-----EMSRAQA 2424 Query: 1467 GKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGK 1526 E A + A E+ + E+ + QT E + + + L + + E + Sbjct: 2425 RAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELER 2484 Query: 1527 EILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQ 1586 E + + + + T+ +E ++ T ++QS E S + R + + + Sbjct: 2485 EKEKLQQEAKLLQLKSEEMQTVQQEQLLQE-TQALQQSFLSE-KDSLLQRERFIEQEKAK 2542 Query: 1587 LEDM-------RQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQ 1639 LE + Q+L + Q QQ E RQ + ME R Q + +E ++R +L Q Sbjct: 2543 LEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQ 2602 Query: 1640 --RSSIDNENLVSERERVLLEELEALKQ---LSLAGREKLCCELRNSSTQTQNGNE 1690 + E L++E + L E+L+ L++ +LA E++ ++ NG + Sbjct: 2603 LEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRD 2658 Score = 151 bits (382), Expect = 1e-35 Identities = 318/1657 (19%), Positives = 679/1657 (40%), Gaps = 234/1657 (14%) Query: 1992 QQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDL 2051 QQLLQ E+ +E+ Q +++D ++ Q++A E ++ + L++E E Sbjct: 993 QQLLQSLEQGAQEESRCQRCISELKD-IRLQLEACETRTVHRLR--LPLDKEPARECAQR 1049 Query: 2052 RQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREV 2111 + Q + ++E + K + + + E ++ L + P + E ++ Sbjct: 1050 IAEQQKAQAEVEGLGKGVARLSAEAE--------KVLALPEPSPAAPTLRSELELTLGKL 1101 Query: 2112 EQLANHLKEKTDKCSELLL------SKEQLQRDIQERNEEIEKLEFRVRELEQALLVEDR 2165 EQ+ + +K + L E++ R +E+ +E + + + ELE + Sbjct: 1102 EQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKK 1161 Query: 2166 KHFGAVEAKPEL-SLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQ 2224 A +P +L +L+ ++ +R ++ + ++E++RE + E Q + Q Sbjct: 1162 LRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQ 1221 Query: 2225 LEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEV 2284 +++++E L++L ++ + +++ + LG ++++ Q Q + +Q ++E+ Sbjct: 1222 TDVRQRE----LEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLAD-SQAVREQLR 1276 Query: 2285 EIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRN-REEEIEQ 2343 + L E++ + + K+ + ++ I+D E Q+ + E V ++ +++ Sbjct: 1277 QEQALLEEIERHGE--KVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQS 1334 Query: 2344 LNE-VIEKLQQELANIGQKTSMNAHSLS---------EEADSLKHQLDVVIAEKLA---- 2389 +E VI++ + + T++ + + EE + L Q E+LA Sbjct: 1335 GSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEA 1394 Query: 2390 -LEQQVETANEEMTFMKNVLKETNFKMNQLTQELF--------SLKRERESVEKIQSIPE 2440 LE+Q + A +E ++ +E+ + +++R E++Q + + Sbjct: 1395 ALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQ 1454 Query: 2441 NS-VNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENG-KGSIINLETRLLQLES 2498 +S + + E + E+ ++ + Q + G +G + L R + E+ Sbjct: 1455 SSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEA 1514 Query: 2499 TVSAKDLELTQCYKQIKD-MQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQ 2557 E + +Q++D Q + Q E E+ + + E++ A + +++L+A + Sbjct: 1515 QKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQA-E 1573 Query: 2558 EYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILE 2617 E + + + + + ++ + E EL S ++ + ++LE + E H ++ Sbjct: 1574 EAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQL 1633 Query: 2618 KEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREK----------EKKRSPQDVEVLKTT 2667 +E+ E + E E+ E ++ LE + K E +++S E K Sbjct: 1634 REEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK 1693 Query: 2668 TELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQ 2727 E G E +A+R +A + EL ++ AE ++ L E + L+ + Q Sbjct: 1694 EEAEREARRRGKAEE-QAVRQRELAEQ-ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQ 1751 Query: 2728 VRDHLAEAKEKLSILEKEDETEVQ-----ESKKACMFEPLPIKLSKSIASQTDGTLKISS 2782 +E+L+ L++E Q E++ A + + + L+ ++ + S+ Sbjct: 1752 GEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR---ST 1808 Query: 2783 SNQTPQILVKNAGIQINLQSECSS----EEVTEIISQFTEKIEKMQELHAAEILDMESRH 2838 S ++ Q L AG L E + E + Q E+ Q A +L + Sbjct: 1809 SEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAA 1868 Query: 2839 ISETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREI------ 2892 I E LK E +A LKE + E + LA +A+Q R + Sbjct: 1869 IGEATRLKTEAEIA---LKE------------KEAENERLRRLAEDEAFQRRRLEEQAAQ 1913 Query: 2893 -------------CSSDSGSDWGQGIY--------------LTHSQGFDIASEGRGEES- 2924 +SDS + +G+ L F+ A+ G+ E Sbjct: 1914 HKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELEL 1973 Query: 2925 ------ESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVS--EPWLEER 2976 +A D+ K + L A Q+ + E + E+ + ++ E +R Sbjct: 1974 ELGRIRSNAEDTLRSKEQAELEAARQR--QLAAEEERRRREAEERVQKSLAAEEEAARQR 2031 Query: 2977 KAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLA--------------- 3021 KA + + LK + + + RE +S++ + + + L A Sbjct: 2032 KAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQE 2091 Query: 3022 LQQVFLEERSVL------------------LAAFRTELTALGTTDAVGLLNCLEQRIQEQ 3063 LQQ +E+SVL A + E A + V L+Q +EQ Sbjct: 2092 LQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQ 2151 Query: 3064 G---VEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQ 3120 + QAA E L+K + QA A + ++ ++ +K +++ L Q Sbjct: 2152 AQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQV 2211 Query: 3121 KQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKE 3180 +Q ++ ++++L + L E+L K E + +Q + EL +++ Q + L + Sbjct: 2212 EQ-ELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEEL-FSVRVQMEELSK 2269 Query: 3181 LEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEK---------EKAKLGRSEERDK 3231 L+A R+E +++ + ++T Q+++ +++ E+ E A+L + E D Sbjct: 2270 LKA-RIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDL 2328 Query: 3232 EELEDLKFSLESQKQRNLQLNL-------LLEQQKQLLNESQQKIESQRMLYDAQLSEE- 3283 + L + +K + +Q LL+QQK+L E ++++ + QL+EE Sbjct: 2329 AQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEET 2388 Query: 3284 QG----------RNLELQVLLESEKVRIREMSSTLDR-ERELHAQLQSSDGTGQS--RPP 3330 QG R LE+ E K+R+ EMS R E + + ++ G+ R Sbjct: 2389 QGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTE 2448 Query: 3331 LPSEDLLK-----ELQKQ-----LEEKHSRIVELLNETEKY---------KLDSLQTRQQ 3371 L +++ + E+Q+Q E I EL E EK K + +QT QQ Sbjct: 2449 LATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQ 2508 Query: 3372 ME--KDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDL--------QRQLEEKRQQVYKL 3421 + ++ Q +++ +E+++ + ++ + + ++K+E L Q+ EE+++Q ++ Sbjct: 2509 EQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQM 2568 Query: 3422 DLEGQRLQGIMQEFQKQELEREEKRESRRILYQNLNE 3458 + E QRL M+E ++++ E EE ++ Q L + Sbjct: 2569 EQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQ 2605 Score = 147 bits (370), Expect = 3e-34 Identities = 322/1585 (20%), Positives = 651/1585 (41%), Gaps = 255/1585 (16%) Query: 1858 LEAISETSSQLEHAKVTQTELMRESFRQKQEATESLK--------CQEELRERLHEESRA 1909 L+ Q++ + ++ +RE RQ+Q E ++ CQ ++ ++ Sbjct: 1250 LQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY 1309 Query: 1910 REQLAVELSK----------------AEGVIDGYADEKT-------LFERQIQEKTDIID 1946 QL ++ +E VI Y D +T L + I+ ++ + Sbjct: 1310 ELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLR 1369 Query: 1947 RLEQELLCASN-------RLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETE 1999 R+E+E A RL E+EA ++ ++ E ++ K + EA ++Q++ +E Sbjct: 1370 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1429 Query: 2000 KLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEK---NTELMDLRQQNQ 2056 + + ++ Q Q ++++LQ+ ++ E +++ + + E+ + E+ +R Q + Sbjct: 1430 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE 1489 Query: 2057 ALEKQ---LEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQ 2113 A E+Q E + L +A + E ++ Q+E ++L +Q+ Q S+ + + + Sbjct: 1490 ATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQV------QDESQRKRQAEVE 1543 Query: 2114 LANHLKEKTDKCSE---LLLSKEQLQRDIQERNEEIEKLEF-RVRELEQALLVEDRKHFG 2169 LA+ +K + + E L + E+L+ +E + + E R R+++ AL R Sbjct: 1544 LASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA 1603 Query: 2170 AVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLE---QFREELENKNEEVQQLHMQLE 2226 +++K E Q ER ++ + + L E+ E Q + E E EE ++ + + Sbjct: 1604 ELQSKRASFAEKTAQLER-SLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ 1662 Query: 2227 IQKKESTT-RLQ--ELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKE 2283 ++ E+ RLQ E+ Q+ L + + EK KE + + GK +E+ Sbjct: 1663 LKANEALRLRLQAEEVAQQKSLAQAEAEKQ----KEEAEREARRR----GK----AEEQA 1710 Query: 2284 VEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQ 2343 V +L EQ + Q+QL T + + + ELIR L ++ E E++ + Sbjct: 1711 VRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR--------LRAETE----QGEQQRQL 1758 Query: 2344 LNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTF 2403 L E + +LQ+E A QK L E ++ +++V++A K E++ + +E+ Sbjct: 1759 LEEELARLQREAAAATQKRQ----ELEAELAKVRAEMEVLLASKARAEEESRSTSEKS-- 1812 Query: 2404 MKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVN--------------VAIDH 2449 K L+ + +L +E L+ E ++ + + E AI Sbjct: 1813 -KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGE 1871 Query: 2450 LSKDKPELEVVLTE-----DALKSLENQTYF--KSFEENGKGSIINLETRLLQLESTVSA 2502 ++ K E E+ L E + L+ L F + EE ++E RL QL A Sbjct: 1872 ATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRK---A 1928 Query: 2503 KDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKF 2562 D EL + ++D Q + ++++I+ L+ E+ A +++L ++ A+ Sbjct: 1929 SDSELERQKGLVEDTLRQRR----QVEEEILALKASFEKAAAGKAELELELGRIRSNAE- 1983 Query: 2563 CQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVE 2622 T+ S+ + L R+ +L ++ R E E +V + SL E+E Sbjct: 1984 ----DTLRSKEQA----ELEAARQRQLAAEEER---RRREAEERVQK---SLAAEEEAAR 2029 Query: 2623 IAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNE 2682 K LE+ ++L K ++ RE+ ++ S + +++ + + Sbjct: 2030 -QRKAALEEVERL----KAKVEEARRLRERAEQESARQLQLAQEAAQ------------- 2071 Query: 2683 LEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSIL 2742 + L+AE KA + ++K ++LQ+ L +++ + L+ + R EA+E Sbjct: 2072 -KRLQAEE---KAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQA 2127 Query: 2743 EKE---DETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQIN 2799 E+E +V+E+++ + + + K + + + A ++ Sbjct: 2128 EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK 2187 Query: 2800 LQSECSSEEVTEIISQ-FTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLLKE 2858 ++ E+ + Q +K + QEL + + ET+ K LL E Sbjct: 2188 QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRL------QLEETDHQKN-------LLDE 2234 Query: 2859 ECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIASE 2918 E LKA +++ S + E S Q E+ + I +E Sbjct: 2235 ELQRLKAEAT-EAARQRSQVEEELFSVRVQMEELSKLKAR----------------IEAE 2277 Query: 2919 GRGE--ESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEER 2976 R + T F ++ ++ V E ++ + E ++Q++E L ++ Sbjct: 2278 NRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQ------EAARLRQLAEEDLAQQ 2331 Query: 2977 KAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAA 3036 +A K L KMQ +EA + LL Q+ +E++ L Sbjct: 2332 RALAE-----KMLKEKMQAVQEATRLKAEAE-----------LLQQQKELAQEQARRLQE 2375 Query: 3037 FRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGR 3096 + ++ + G LE Q Q +E A E L+ R + +S QA A+ + + Sbjct: 2376 DKEQMAQQLAEETQGFQRTLEAERQRQ-LEMSAEAERLKL--RVAEMSRAQA-RAEEDAQ 2431 Query: 3097 KITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAEL 3156 + + E+ EK + E Q+K + + ++++ A L+E +AEL Sbjct: 2432 RFRKQAEEIGEKLHRT--ELATQEKVTLVQTLEIQRQQSDHDAERLRE-------AIAEL 2482 Query: 3157 KSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWAL 3216 + E + KL+ E L LK E ++ + E L + SE+ + + + Sbjct: 2483 ERE--KEKLQQEAKLL----QLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFI 2536 Query: 3217 EKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLY 3276 E+EKAKL + + + + + L+ + Q+Q+ +EQ++Q L S + E++R + Sbjct: 2537 EQEKAKLEQLFQDEVAKAQQLREEQQRQQQQ-------MEQERQRLVASME--EARRRQH 2587 Query: 3277 DAQ----LSEEQGRNLELQ-----VLLESEKVRIREMSSTLDRERE---LHAQLQSSDGT 3324 +A+ +E+ + LE Q LL E R+RE L+ + H++ ++ Sbjct: 2588 EAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQV 2647 Query: 3325 GQSRPPLPSEDLLKELQKQLEEKHS 3349 ++ D L + E +HS Sbjct: 2648 AATKTLPNGRDALDGPAAEAEPEHS 2672 Score = 141 bits (356), Expect = 1e-32 Identities = 365/1881 (19%), Positives = 749/1881 (39%), Gaps = 298/1881 (15%) Query: 417 DIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALR 476 DI ++E R + +LR LD+ ++ Q + Q AQ E+E + Sbjct: 1018 DIRLQLEACETRTVHRLRLPLDKEPARECAQ---RIAEQQKAQ---------AEVEGLGK 1065 Query: 477 SYSNITVNEDQIKLM---NVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQ---RQL 530 + ++ +++ + + A L +L+ T + E+++ + LE+ + R Sbjct: 1066 GVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGT 1125 Query: 531 EDLVEELSFSREQIQRARQ---TIAEQES------KLN-EAHKSLSTVEDLKAEIVSASE 580 + E L EQ++ A+ T+ E E+ KL +A T + L+ E+ A E Sbjct: 1126 QGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQE 1185 Query: 581 SRKELELKH---EAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEEL 637 + L+ +H + EV ++ ++ L + AVL + + ++ ELE+L QL + E Sbjct: 1186 VGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQ-TDVRQRELEQLGRQLRYYRESAD 1244 Query: 638 ---SKLKEDLEIEHRINIEKLKDNLGIHYK-QQIDGLQNEMS---QKIETMQ-FEKDNLI 689 + L++ + +I L D+ + + +Q L E+ +K+E Q F K + Sbjct: 1245 PLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYIN 1304 Query: 690 TKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQE----V 745 ++ + ++ L+ +K ++ + +E LR E TL + + Sbjct: 1305 AIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFI 1364 Query: 746 QELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIF 805 E + E E+ +++ + +E+ A++EA L+ +++ E + +E + Sbjct: 1365 SETLRRMEEEERLAEQQRAEERERLAEVEAA---LEKQRQLAEAHAQAKAQAEREAK--- 1418 Query: 806 LDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQ 865 ++ + ++ V +E E D +QQ + EE+++ R + +E + ++ + Sbjct: 1419 --ELQQRMQEEVVRRE-----EAAVDAQQQKRSIQEELQQLRQS---SEAEIQAKARQAE 1468 Query: 866 EEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVA 925 L++++++ + + E + + A E LQ + + + A Sbjct: 1469 AAERSRLRIEEEIRVVRLQLEATERQRGGAEGE---LQALRARAEEAE-----------A 1514 Query: 926 ETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQ 985 + + E E+ ++ ++ + ++ ++EL+ R+ +E ++K + L E L+ Sbjct: 1515 QKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE----LRL 1570 Query: 986 EKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEE 1045 + E+ R R+ E+ RA VQ + R AE + SF E+ Sbjct: 1571 QAEEAERRLRQAEV----ERARQVQVA-----------LETAQRSAEAELQSKRASFAEK 1615 Query: 1046 SKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSE 1105 + + E S QE+ + + + +E+ RA Q +E ++ ++E +E Sbjct: 1616 TAQL-------------ERSLQEEHVA--VAQLREEAERRAQQQAEAERAREE-----AE 1655 Query: 1106 QNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIH 1165 + R Q++A + + V Q + + E +K +EE +E ++ Sbjct: 1656 RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQ-----------KEEAEREARRRG 1704 Query: 1166 QLELQTMKTQETGDEG--KPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVN 1223 + E Q ++ +E ++ K L G Q+ ++ E L+ E Sbjct: 1705 KAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELI--------------RLRAETE 1750 Query: 1224 AEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQ 1283 +++ + E E LQ ++ + L KV E LL SK + Sbjct: 1751 QGEQQRQ---LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLA-----SKARAE 1802 Query: 1284 QTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQEL 1343 + E ++ L E F + + L + K + + L + Q E Sbjct: 1803 EESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ----RQLAEEDAARQRAEA 1858 Query: 1344 ESLISSLQQQLKE-TEQNYEAEIHCLQK-----RLQAVSESTVPPSLPVDSVVIT-ESDA 1396 E +++ + E T EAEI +K RL+ ++E ++ ++D Sbjct: 1859 ERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI 1918 Query: 1397 QRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFA 1456 + + + ++K D +E + G+ E+T + + Q+EEE+ + S A A Sbjct: 1919 EERL---AQLRKASDSELE--RQKGLVEDT-------LRQRRQVEEEILALKASFEKAAA 1966 Query: 1457 QQTELS----RISGGKENTASSK---------QAHAVCQQEQHY------------FNEM 1491 + EL RI E+T SK Q ++E+ E Sbjct: 1967 GKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 2026 Query: 1492 KLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDI--PESKDCVLTIS 1549 Q + + E + K +E + + E +++ L+ E K + Sbjct: 2027 AARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQ 2086 Query: 1550 EEMFSKDKTFIVRQSIHDEISVSSMDASR--------QLMLNEEQLEDMRQ----ELVRQ 1597 ++ +T QS+ D++ + A R ++ E + RQ E ++Q Sbjct: 2087 QKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQ 2146 Query: 1598 YQEHQQATELLRQAHMRQMERQREDQ--EQLQEEIKRLNRQLAQRSSIDNENLVSE---R 1652 E Q QA ++ ++ E + + Q E L ++ A + ++ +E R Sbjct: 2147 SAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLR 2206 Query: 1653 ERVLLE-ELEALK-QLSLAGREK--LCCELRNSSTQTQNGNENQGEVEEQTFKEKELDRK 1708 ++ +E EL L+ QL +K L EL+ + + +VEE+ F + + Sbjct: 2207 QKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE 2266 Query: 1709 PEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSAS 1768 + I + R + + + + L E + V E R S +Q +A Sbjct: 2267 LSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAAR-------LSVAAQEAAR 2319 Query: 1769 LIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRS 1828 L +E + + + + E+ + +++ + + +++ ++ EL+Q R Sbjct: 2320 LRQLAEEDLAQQRALAEKMLKEKMQAVQEATR-------LKAEAELLQQQKELAQEQAR- 2371 Query: 1829 GFAGTEIDPENEELMLNISSRLQAAVEKLLEAIS----ETSSQLEHAKVTQTELMRESFR 1884 + + E++ ++ Q ++ LEA E S++ E K+ E+ R R Sbjct: 2372 -----RLQEDKEQMAQQLAEETQG-FQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQAR 2425 Query: 1885 QKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDI 1944 +++A K EE+ E+LH A ++ + E Q Q+ Sbjct: 2426 AEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT--------------LEIQRQQSDHD 2471 Query: 1945 IDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKE 2004 +RL + + ELE E++++Q+E +LL + E M+ ++QLLQET+ L + Sbjct: 2472 AERLREAIA-------ELEREKEKLQQEAKLLQLKSEEMQTVQ---QEQLLQETQALQQS 2521 Query: 2005 KLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEK 2064 L +D L ++ E +E++ ++ +L Q++ + LR++ Q ++Q+E+ Sbjct: 2522 FL-------SEKDSLLQR----ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2570 Query: 2065 MRKFL---DEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEK 2121 R+ L E+A R+HE + + Q+ QQL E Q R+ E+L L E+ Sbjct: 2571 ERQRLVASMEEARRRQHEAEEGVRRKQEELQQL----------EQQRRQQEEL---LAEE 2617 Query: 2122 TDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVEDRKHFGAVEAKPELSLEV 2181 + E L E+ R +EE+ + V + D A EA+PE S + Sbjct: 2618 NQRLREQLQLLEEQHRAALAHSEEVTASQ--VAATKTLPNGRDALDGPAAEAEPEHSFD- 2674 Query: 2182 QLQAERDAIDRKEKEITNLEE 2202 L+ + A +E I + EE Sbjct: 2675 GLRRKVSAQRLQEAGILSAEE 2695 Score = 139 bits (349), Expect = 7e-32 Identities = 361/1895 (19%), Positives = 769/1895 (40%), Gaps = 224/1895 (11%) Query: 424 QETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITV 483 QE +LE L ++ Q V MK L Q + + ++ +RS+S T Sbjct: 893 QEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQL-----------IRSWSLATF 941 Query: 484 NEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQ 543 + + A++ L + Q + + G E++ +R+ S +Q Sbjct: 942 RTLKPEEQRQALHSLELHYQAFLRDSQ---DAGGFGPEDRLMAEREYGSC----SHHYQQ 994 Query: 544 IQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEML 603 + ++ + A++ES+ + +S ++D++ ++ A E+R T ++++L + Sbjct: 995 LLQSLEQGAQEESR---CQRCISELKDIRLQL-EACETR-----------TVHRLRLPLD 1039 Query: 604 EKEKNAVLDRMAESQ--EAELERLRTQL--LFSHEEELSKLKEDLEIEHRINIEKLKDNL 659 ++ R+AE Q +AE+E L + L + E++ L E + E L Sbjct: 1040 KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSEL---EL 1096 Query: 660 GIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQ--------SLVN 711 + +Q+ L +K++T+ + L +LK+ Q Sbjct: 1097 TLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATK 1156 Query: 712 SKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFA 771 + +++ Q Q + LR E + + + +Q+ + ++ ++ +E+ L E++ Sbjct: 1157 ASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQ 1216 Query: 772 QLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEIL-IEENE 830 + A+ + + E + L L+ + S + +L + + +++I+ + + +++ Sbjct: 1217 AVLAQTDVRQRELEQLGRQLRYYRE-SADPLGAWLQDARRR------QEQIQAMPLADSQ 1269 Query: 831 DLKQQCIQ---LNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQEL 887 +++Q Q L EEIE+ ++ + +++ L+ K LE + + Sbjct: 1270 AVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAK- 1328 Query: 888 EYKSKLKALNEELHLQRINPTTVKMK-SSVFDEDKTFVAETLEMGEVVEKDTTELMEKLE 946 K K+++ +E + + ++ T + +++ + F++ETL E E+ L E+ Sbjct: 1329 --KPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER----LAEQQR 1382 Query: 947 VTKREKLELSQRLSDLSEQLKQKHGEISFLNE-EVKSLKQEKEQVSLRCRELEIIINHNR 1005 +RE+L + + QL + H + E E K L+Q ++ +R RE + + Sbjct: 1383 AEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR-REEAAVDAQQQ 1441 Query: 1006 AENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEES 1065 ++Q Q+ + + +R AE + E S++ +E+++ + + Sbjct: 1442 KRSIQEELQQLRQSSEAEIQAKARQAEAA---------ERSRLRIEEEIRVVRLQLEATE 1492 Query: 1066 KQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYS 1125 +Q L +LRA +E + QK ++E+ ++Q E+QR + V Sbjct: 1493 RQRGGAEGEL------QALRAR--AEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVEL 1544 Query: 1126 THVDQVREYMENEKDKALCSLKEELIFAQEEKIK----ELQKIHQLELQTMKTQETGDEG 1181 + EK +AL +L+E + A+E + + E+++ Q+++ Q + + Sbjct: 1545 ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE-- 1602 Query: 1182 KPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPE 1241 +LQ + Q S+ E+ A E + + E+ E Sbjct: 1603 -------AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAE 1655 Query: 1242 LQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEE 1301 + R++++ + L + + L + K ++ + + E+ + + E Sbjct: 1656 RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRE 1715 Query: 1302 TEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNY 1361 + Q E + +L++ Q+L + + E + E + + L+++L ++ Sbjct: 1716 LAEQELEKQRQLAEG---TAQQRLAAEQELIRLRAETEQGEQQRQL--LEEELARLQREA 1770 Query: 1362 EAEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFG 1421 A QKR + +E + + V+ S A+ S +K+ +G F Sbjct: 1771 AA---ATQKRQELEAELA---KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFR 1824 Query: 1422 -VKEETNIVKLL--EKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAH 1478 + EE ++ L E + Q QL EE A + A A++ +++ E T +A Sbjct: 1825 ELAEEAARLRALAEEAKRQRQLAEEDA----ARQRAEAERVLAEKLAAIGEATRLKTEAE 1880 Query: 1479 AVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDI 1538 ++++ ++ + FQ + L ++ +H DI Sbjct: 1881 IALKEKEAENERLRRLAEDEAFQR------------RRLEEQAAQHKA----------DI 1918 Query: 1539 PESKDCVLTISEEMFSKDKTFI---VRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELV 1595 E + S+ + K + +RQ E + ++ AS + + ++ + Sbjct: 1919 EERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRI 1978 Query: 1596 RQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERV 1655 R A + LR ++E R+ Q +EE +R + + S+ E + + + Sbjct: 1979 RS-----NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA 2033 Query: 1656 LLEELEALKQLSLAGREKLCCELRNSSTQTQNGNEN-----QGEVEEQTF----KEKELD 1706 LEE+E LK R + S+ Q Q E Q E + F KE+EL Sbjct: 2034 ALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQ 2093 Query: 1707 R--KPEDVPPEILSNE----RYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRS 1760 + + E + L E R A ++A ++ E ++ VEE L +S Sbjct: 2094 QTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER------LKQS 2147 Query: 1761 SKSQSSASLIWRSEAEASVKSCVHEEHTRVTDE--SIPSYSGSDMPRNDINMWSKVT-EE 1817 ++ Q+ A ++ AE K E R E ++ +D +++ T + Sbjct: 2148 AEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ 2207 Query: 1818 GTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTE 1877 ++ Q L E D + + L+ RL+A + S+ +L +V E Sbjct: 2208 KAQVEQELTTLRLQLEETDHQ-KNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE 2266 Query: 1878 LMRESFR-QKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFER 1936 L + R + + L+ ++ + L EE+ +Q+A E ++ A + L E Sbjct: 2267 LSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE 2326 Query: 1937 QIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQ 1996 + ++ + +++ +E + A L+AE + +Q+++EL Q ++ + + QQL + Sbjct: 2327 DLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAE 2386 Query: 1997 ETEKLMK-------EKLEVQCQAEKVR--------------DDLQKQVKALEIDVEEQVS 2035 ET+ + +LE+ +AE+++ +D Q+ K E ++ E++ Sbjct: 2387 ETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE-EIGEKLH 2445 Query: 2036 RFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLK 2095 R QEK T + L Q Q + E++R+ + E E E++ QQE + L QLK Sbjct: 2446 RTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAEL----EREKEKLQQEAKLL--QLK 2499 Query: 2096 VVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKE----QLQRDIQERNEEIEKL-- 2149 E QT + EQL ++T + LS++ Q +R I++ ++E+L Sbjct: 2500 S-------EEMQTVQQEQLL----QETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQ 2548 Query: 2150 -----EFRVRELEQALLVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQL 2204 ++RE +Q + + + A E + Q +AE + + RK++E+ LE+Q Sbjct: 2549 DEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAE-EGVRRKQEELQQLEQQR 2607 Query: 2205 EQFREELENKNEEVQQLHMQLEIQKKESTTRLQEL 2239 Q E L +N+ +++ LE Q + + +E+ Sbjct: 2608 RQQEELLAEENQRLREQLQLLEEQHRAALAHSEEV 2642 Score = 125 bits (315), Expect = 6e-28 Identities = 335/1644 (20%), Positives = 647/1644 (39%), Gaps = 231/1644 (14%) Query: 2109 REVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEF-RVRELEQALLVEDRKH 2167 RE ++H ++ + + + QR I E + +LE R + + L D++ Sbjct: 983 REYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEP 1042 Query: 2168 FGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEI 2227 A E ++ + + QAE + + K + L + E+ L + L +LE+ Sbjct: 1043 --ARECAQRIAEQQKAQAEVEGLG---KGVARLSAEAEKVLA-LPEPSPAAPTLRSELEL 1096 Query: 2228 QKKESTTRLQELEQENKLFKDDMEKLGLAIKESD-AMSTQDQHVLFGKFAQIIQEKEVEI 2286 + +L+++ + ++ + ++ + L I+ + A H K AQ + E+ Sbjct: 1097 ----TLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPEL 1152 Query: 2287 DQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNE 2346 + + KL+ Q + + + +R + E L R+ E+E+ E Sbjct: 1153 EATKASLKKLRAQAE--AQQPTFDALRDELRGAQEVGERLQQRHG----ERDVEVERWRE 1206 Query: 2347 VIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKL-ALEQQVETANEEMTFMK 2405 + +L + + +T + L + L++ + A+ L A Q E++ M Sbjct: 1207 RVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRES--ADPLGAWLQDARRRQEQIQAMP 1264 Query: 2406 NVLKETNFKMNQLTQE---LFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLT 2462 L ++ QL QE L ++R E VE+ Q + +N D+ EL++V Sbjct: 1265 --LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY------ELQLVTY 1316 Query: 2463 EDALKSLENQTYFKSFEENGKGSII----NLETRLLQLESTVSAKDLELTQCYKQIKDMQ 2518 + L+ + + K ++G S+I +L T +L + S +++ +++++ + Sbjct: 1317 KAQLEPVASPAK-KPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEE 1375 Query: 2519 EQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNI 2578 + Q++ +++ E V AAL Q QL AK +E E + Sbjct: 1376 RLAE------QQRAEERERLAE--VEAALEKQRQLAEAHAQAK-------AQAEREAKEL 1420 Query: 2579 QNLNQ---LREDELGSDISALTLRISELESQVVEMHTSLILEK-EQVEIAEKNVLEKEKK 2634 Q Q +R +E D I E Q+ + + I K Q E AE++ L E++ Sbjct: 1421 QQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEE 1480 Query: 2635 LLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATK 2694 + ++ LE E+++ G EL+ALRA + + Sbjct: 1481 IRVVRLQLEATERQR---------------------------GGAEGELQALRARAEEAE 1513 Query: 2695 AELASYKEKAEKLQEELLVKETNMTSLQKDL-SQVRDHLAEAKEKLSILEKEDETEVQES 2753 A+ +E+AE+L+ ++ + + +L S+V+ A+EK L+ +E +Q Sbjct: 1514 AQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAE 1573 Query: 2754 KKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGI-QINLQSECSSEEVTEI 2812 + ++ ++ Q L+ + + ++ K A + Q E S +E Sbjct: 1574 EAERRLRQAEVERAR----QVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVA 1629 Query: 2813 ISQFTEKIEKMQELHA-AEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLR 2871 ++Q E+ E+ + A AE E+ E LK + ++L EE K++ Q Sbjct: 1630 VAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEA 1689 Query: 2872 SKEGSSIPE------LAHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESE 2925 K+ A A + RE+ + +EG ++ Sbjct: 1690 EKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ-------------LAEGTAQQRL 1736 Query: 2926 SATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSI-----QQVSEPWLEERKAYI 2980 +A + LRA +G Q L E + + + +Q E L + +A + Sbjct: 1737 AAEQELIR-----LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEM 1791 Query: 2981 NTISSLK--------DLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSV 3032 + + K K + + EAE + E + R A +Q L E Sbjct: 1792 EVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDA 1851 Query: 3033 LLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQK-----ADRRSLLSEIQ 3087 E A+G L+ + E +A E L++ A +R L E Sbjct: 1852 ARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA 1911 Query: 3088 ALH-AQMNGRKITLKREQESEKPSQE-LLEYNIQQKQSQMLEMQVELSSMKDRATELQEQ 3145 A H A + R L++ +SE Q+ L+E ++Q++ +++ E+ ++K Sbjct: 1912 AQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRR----QVEEEILALK--------- 1958 Query: 3146 LSSEKMVV--AELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLA 3203 S EK AEL+ EL + + E TL++ K ELEA R A Sbjct: 1959 ASFEKAAAGKAELELELGRIRSNAEDTLRS--KEQAELEAARQR------------QLAA 2004 Query: 3204 SEQKKSRELQWALEKEKA---KLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQ 3260 E+++ RE + ++K A + R + EE+E LK +E ++ + +Q Q Sbjct: 2005 EEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQ 2064 Query: 3261 LLNESQQK---IESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDREREL--- 3314 L E+ QK E + + Q E+ ELQ L+ E+ + ++ + R Sbjct: 2065 LAQEAAQKRLQAEEKAHAFAVQQKEQ-----ELQQTLQQEQSVLDQLRGEAEAARRAAEE 2119 Query: 3315 --HAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIV----ELLNETEKYKLDSLQT 3368 A++Q+ QSR + + LK+ ++ + ++ +L E E+ Q Sbjct: 2120 AEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQA 2179 Query: 3369 RQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRL 3428 Q + +Q ++ ++ + ++ +++ ++ L+ QLEE Q LD E QRL Sbjct: 2180 EQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRL 2239 Query: 3429 QGIMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYA 3488 + E +Q + EE+ S R+ + L++ L+ +IE E + Sbjct: 2240 KAEATEAARQRSQVEEELFSVRVQMEELSK---------------LKARIEAENR----- 2279 Query: 3489 KLIEMNGGGTGCNHELEMIRQKLQCVASKLQVLPQKASERLQFETADDEDFIWVQENIDE 3548 LI + T L+ +K++ VA + L A E + +ED + Q + E Sbjct: 2280 ALILRDKDNT--QRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED-LAQQRALAE 2336 Query: 3549 IILQLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKL 3608 +L+ E+ V +T + E LL+Q EL ++ +E D M +L Sbjct: 2337 KMLK---------EKMQAVQEATRLKAEAE-LLQQQKELAQEQARRLQE--DKEQMAQQL 2384 Query: 3609 EEQIRWYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRAE--AEVY 3666 E+ + +++T L + +++E E + ++ RAE A+ + Sbjct: 2385 AEETQGFQRT-----------LEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRF 2433 Query: 3667 KLKAELRNDSLLQTLSPDSEHVTL 3690 + +AE + L +T E VTL Sbjct: 2434 RKQAEEIGEKLHRTELATQEKVTL 2457 Score = 48.5 bits (114), Expect = 1e-04 Identities = 142/683 (20%), Positives = 274/683 (40%), Gaps = 64/683 (9%) Query: 3052 LLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNG---RKITLKREQESEK 3108 LL LEQ QE+ C + +SE++ + Q+ R + R ++ Sbjct: 995 LLQSLEQGAQEES-------RC------QRCISELKDIRLQLEACETRTVHRLRLPLDKE 1041 Query: 3109 PSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQT-KLEL 3167 P++E + +Q+++Q E+ + L + +EK++ S A T + EL Sbjct: 1042 PARECAQRIAEQQKAQ-----AEVEGLGKGVARLSAE--AEKVLALPEPSPAAPTLRSEL 1094 Query: 3168 ETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSE 3227 E TL + + ++ L A LE K KT + + A E ++ E Q + Sbjct: 1095 ELTL-GKLEQVRSLSAIYLE-KLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPEL 1152 Query: 3228 ERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRN 3287 E K L+ L+ E+Q+ L L +++ QQ+ +R + + E + Sbjct: 1153 EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQR-HGERDVEVERWRERVAQL 1211 Query: 3288 LEL-QVLLESEKVRIREMSST---LDRERE----LHAQLQSSDGTGQSRPPLPSEDLLKE 3339 LE Q +L VR RE+ L RE L A LQ + + +P D + Sbjct: 1212 LERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADS-QA 1270 Query: 3340 LQKQLEEKHSRIVELLNETEKYKLDSLQTRQQME--KDRQVHRKTLQTEQEANTEGQKKM 3397 +++QL ++ + + E+ EK + +Q + KD ++ T + + E KK Sbjct: 1271 VREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKP 1330 Query: 3398 HELQSKVEDLQRQLEEKRQQVYKLD-LEGQRLQGIMQEFQKQELEREEKRESRRILYQNL 3456 ++QS E + ++ + R +L L Q ++ I + ++ E E + R + L Sbjct: 1331 -KVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERL 1389 Query: 3457 NEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMI--RQKLQCV 3514 E +L R + + + + + AK ++ E + +Q+ + + Sbjct: 1390 AEVEA-ALEKQRQ---LAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSI 1445 Query: 3515 ASKLQVLPQKASERLQFET----ADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSPS 3570 +LQ L Q + +Q + A + + ++E I + LQL+ Q+G + Sbjct: 1446 QEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL 1505 Query: 3571 TSCGSLTERLLRQNAELTGHIS-QLTEEKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRFS 3629 + E RQ E + Q+ +E R ++L +++ + A R+ Sbjct: 1506 RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVK--AEAEAAREKQRALQ 1563 Query: 3630 LNGGANIEAIIA------SEKEVWNREKLTLQKSLKRAEAEVYKLKAELRNDSLLQTLSP 3683 ++A A +E E + ++ L+ + + AEAE+ +A + S Sbjct: 1564 ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1623 Query: 3684 DSEHVTLKRIYGKYLRAESFRKA 3706 EHV + + LR E+ R+A Sbjct: 1624 QEEHVAVAQ-----LREEAERRA 1641 Score = 35.8 bits (81), Expect = 0.85 Identities = 52/235 (22%), Positives = 101/235 (42%), Gaps = 31/235 (13%) Query: 2138 DIQE--RNEEIEKLEFRVRELEQALLVEDRKHFGAVEAK--PELSLEVQLQAERDAIDRK 2193 D+Q+ R E++ REL LL R H A E + P E+++ + + K Sbjct: 294 DVQDGVRANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQ-FLKFK 352 Query: 2194 EKEITNLEEQLEQFREELENKNEEVQQLHMQ-------LEIQKKESTTRLQELEQENKLF 2246 E E+ E + + ++ VQ ++ L+++K+ + LE+E +L Sbjct: 353 EMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQL- 411 Query: 2247 KDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDN 2306 + + E+L Q ++ ++ E + +QLN+ LQ +++ Sbjct: 412 RSEFERLECL-----------QRIV----TKLQMEAGLCEEQLNQADALLQSDVRLLAAG 456 Query: 2307 KVIEEKNELIRDL---ETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANI 2358 KV + E+ RDL ++ I L +D + +K R + EQ+ + +L + L I Sbjct: 457 KVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAI 511 Score = 35.8 bits (81), Expect = 0.85 Identities = 60/292 (20%), Positives = 111/292 (38%), Gaps = 39/292 (13%) Query: 4 EERQKKLEAGKAKLAQFR-------QRKAQSDGQ-----SPSKKQKKKRKTSSSKHDVSA 51 +E+ ++L+ K ++AQ QR +++ Q S ++ K R S+ A Sbjct: 2367 QEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA 2426 Query: 52 HHDLNIDQSQCNEMYINSSQRVESTVIPESTIMRTLH-SGEITSHEQGFSVELESEISTT 110 D + Q E+ R E + T+++TL + + H+ E +E+ Sbjct: 2427 EEDAQRFRKQAEEIG-EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELERE 2485 Query: 111 ADDCSSEVNGCSFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHE 170 + E K L EE V Q Q + L ++ Sbjct: 2486 KEKLQQEA----------KLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERF 2535 Query: 171 IEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLE 230 IE+ +LE++ + Q +E + +Q + +L A++++ARR + E Sbjct: 2536 IEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRR 2595 Query: 231 LTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDH 282 E+ Q+L+ Q +Q + +LL + Q L Q QL E+ H Sbjct: 2596 KQEELQQLEQQRRQQE---------------ELLAEENQRLREQLQLLEEQH 2632 >gi|114155142 nuclear pore complex-associated protein TPR [Homo sapiens] Length = 2363 Score = 182 bits (462), Expect = 6e-45 Identities = 381/1857 (20%), Positives = 779/1857 (41%), Gaps = 315/1857 (16%) Query: 301 LQEKIKVYEMEQ-DKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLL 359 LQ+ ++ E+ + K V+N ++ + ++++ I+ L + EK +E + + +K L Sbjct: 5 LQQVLERTELNKLPKSVQNKLEKFLADQQSEIDGLKGR---HEKFKVESEQQYFEIEKRL 61 Query: 360 GELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIV 419 QE++V + +E ++++LEL + + +E+ K+L E Q RN Sbjct: 62 SHSQERLVNETRECQSLRLELEKLNNQLKALTEKNKEL----EIAQDRNIA--------- 108 Query: 420 QRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIR--QHMAQMEEMKTRHKGEMENALRS 477 ++ + R E+L AE K++LIR + ++Q E T + L+ Sbjct: 109 --IQSQFTRTKEELEAE------------KRDLIRTNERLSQELEYLTEDVKRLNEKLKE 154 Query: 478 YSNITVNEDQIKLMNVAINELNIKLQDTNSQKEK---------LKEELGLILEEKCALQR 528 SN T E Q+KL + +++++K ++ ++EK L EL +E AL R Sbjct: 155 -SNTTKGELQLKLDELQASDVSVKYREKRLEQEKELLHSQNTWLNTELKTKTDELLALGR 213 Query: 529 QLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLST-VEDLKAEIVSASESRKELEL 587 + + + EL + E + + EQ + L +++ L VEDL ++ A E + +E Sbjct: 214 EKGNEILELKCNLENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEE 273 Query: 588 KHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIE 647 K E+ N IKL L K +A D A+S E L E +K +D Sbjct: 274 KFHNEL-NAHIKLSNLYK--SAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQD---- 326 Query: 648 HRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEIS------- 700 H + +E+ KD + ++I L+ E+ + + K + + +S Sbjct: 327 HLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVA 386 Query: 701 -------KLKDLQQSLVNSKSE---------EMTLQINELQKEIE----ILRQEEKEKGT 740 KL +L + V ++ + + ++E+ KE+E IL+++ +E Sbjct: 387 KIVKPGMKLTELYNAYVETQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYER 446 Query: 741 LEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQE 800 ++ V L +K LE+ MKE + LQE + ++S+L+ + + +E +K +SQ+ Sbjct: 447 AQKAVASLSVK---LEQAMKEIQR-LQEDTDKANKQSSVLERDNRRMEIQVK---DLSQQ 499 Query: 801 ERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVN 860 R++ ++ +++ + ++E+ + D+ +++ + RN Sbjct: 500 IRVLLMELEEARGNHVIRDEEVS-----SADISSSSEVISQHLVSYRNI----------- 543 Query: 861 YQELQEEYACLLKVKDDLEDSKNKQELEYKS--------KLK-ALNEELHLQRINPTTVK 911 +ELQ++ LL +L +++ ++E E S KL+ AL E L++ ++ Sbjct: 544 -EELQQQNQRLLVALRELGETREREEQETTSSKITELQLKLESALTELEQLRKSRQHQMQ 602 Query: 912 MKSSVFDE-DKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLS--------DL 962 + S+ + D + + G + + L + + ++ SQ +S + Sbjct: 603 LVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIES 662 Query: 963 SEQLKQKHGEISFLNEEVKSLKQEK-EQVSLRCRELEIIINHNRAENVQSCDTQVSSLLD 1021 +E ++ K + L E ++ K+EK E ++ +LE + + +++S +T++S+ LD Sbjct: 663 TEAIEAK-AALKQLQEIFENYKKEKAENEKIQNEQLEKL--QEQVTDLRSQNTKISTQLD 719 Query: 1022 GV---VTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSV 1078 M EG ++ K+ + KQEQ+I + Sbjct: 720 FASKRYEMLQDNVEGYRREITSLHERNQKLTATTQ------------KQEQIINTMTQDL 767 Query: 1079 TKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEA-------QRICLSLVYSTHVDQV 1131 + A + L+KE +LK + L Q E+ Q + L+ + + + + Sbjct: 768 RGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQT--IQGI 825 Query: 1132 REYMENEKDKALCS----LKEELIFAQEEKIKELQKIH----QLELQTMKTQETGDEGKP 1183 E E E + L S L+ E+ +++ E+++ H L++Q + T+ D Sbjct: 826 LERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETN 885 Query: 1184 LHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAE--DKENSGDYISENEDPE 1241 LHL +L K +E + Q L ++ + + + + + +KE+ D +S+ E Sbjct: 886 LHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTE 945 Query: 1242 LQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEE 1301 Q V D +E + T + V E+Y ++ T L EE+L KE+ Sbjct: 946 EQ-----VNDLKERLKTSTSNV-EQYQAMV---TSL----------------EESLNKEK 980 Query: 1302 TEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNY 1361 Q+T E++ N + +L + + T+LE+++ E+E LQ + ++ Sbjct: 981 --------QVT--EEVRKNIEVRLKESAEFQ-TQLEKKLMEVEKEKQELQDDKRRAIESM 1029 Query: 1362 EAEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFG 1421 E ++ L+K L +V + + E A+R Sbjct: 1030 EQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDC--------------------- 1068 Query: 1422 VKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVC 1481 +E+ I + +Y+ +L A V ++ A Q ++++ + E T ++ + Sbjct: 1069 -QEQAKIAVEAQNKYERELMLHAADV-EALQAAKEQVSKMASVRQHLEETTQKAESQLL- 1125 Query: 1482 QQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPES 1541 + + + ++ +D++ D++ ++ + L ++ + +++ S + P + Sbjct: 1126 ECKASWEERERMLKDEVSKCVCRCEDLE--KQNRLLHDQIEKLSDKVVASVKEGVQGPLN 1183 Query: 1542 KDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEH 1601 +++SEE S+++ + + I E ++ + Q+E +R + Sbjct: 1184 ----VSLSEEGKSQEQILEILRFIRREKEIA------ETRFEVAQVESLR---------Y 1224 Query: 1602 QQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELE 1661 +Q ELL + + ++E++Q K + + + N+V E ++L EE E Sbjct: 1225 RQRVELLERELQELQDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKE 1284 Query: 1662 ALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNER 1721 L+Q L + +L Q N E EK+L EDV N+ Sbjct: 1285 RLEQ-DLQQMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKL--LEEDVKRWKARNQH 1341 Query: 1722 YALQKAN---NRLLKILLEVVKTTAAVE---ETIGRHVLGILDRSSKSQSSASLIWRSEA 1775 Q+ + K+L E T ++ E IGR ++ ++S+ASL Sbjct: 1342 LVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRL------KAEIARSNASLTNNQNL 1395 Query: 1776 EASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEI 1835 S+K +++ R E+I D+ I++ KV + + + G Sbjct: 1396 IQSLKEDLNK--VRTEKETIQK----DLDAKIIDIQEKV--------KTITQVKKIGRRY 1441 Query: 1836 DPENEELMLNISSRLQAAVEKLLEAISETSS--QLEHAKVTQTELMRESFRQKQEATESL 1893 + EEL +A +K++E +++S Q +H V + + ++E+ Q + ++SL Sbjct: 1442 KTQYEEL--------KAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQAETKSKSL 1493 Query: 1894 KCQ-EELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQEL 1952 + Q E L++ L E+ + + L E+ +Q ++++ RL Q+L Sbjct: 1494 ESQVENLQKTLSEKE--------------------TEARNLQEQTVQLQSEL-SRLRQDL 1532 Query: 1953 LCASNRLQELEAEQQQIQEERELLSRQKEAMK---AEAGPVEQQLLQETEKLMKEKLEVQ 2009 +R + E +QQI E+ E + A K A V+ QL +E E+L + + Sbjct: 1533 ---QDRTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALD 1589 Query: 2010 CQAEKVRDDLQKQVKALEIDVEEQVSRF---IELEQEKNTELMDLRQQ--NQALEKQ 2061 Q +D+L ++ AL+ E ++SR + QE++ E D Q+ N+ E+Q Sbjct: 1590 QQ----KDELDVRITALKSQYEGRISRLERELREHQERHLEQRDEPQEPSNKVPEQQ 1642 Score = 174 bits (441), Expect = 2e-42 Identities = 346/1733 (19%), Positives = 733/1733 (42%), Gaps = 240/1733 (13%) Query: 1990 VEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVE----EQVSRFIELEQE-- 2043 V QQ+L+ TE L K VQ + EK D Q ++ L+ E E ++ E+E+ Sbjct: 4 VLQQVLERTE-LNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLS 62 Query: 2044 -KNTELMDLRQQNQALEKQLEKMR---KFLDEQAIDREHERD---VFQQEIQKLEQQLKV 2096 L++ ++ Q+L +LEK+ K L E+ + E +D Q + + +++L+ Sbjct: 63 HSQERLVNETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEELEA 122 Query: 2097 VPR-FQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRE 2155 R +E ++E+E L +K +K E +K +LQ + E +++R + Sbjct: 123 EKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKR 182 Query: 2156 LEQAL-LVEDRKHFGAVEAKPELSLEVQLQAERD--------AIDRKEKEITNLEEQLEQ 2206 LEQ L+ + + E K + + L E+ ++ K++E++ LEEQ+ Sbjct: 183 LEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQMNG 242 Query: 2207 FREELENKNEEVQQLHMQLEIQKKESTTRLQELEQE-------NKLFK---DDMEKLGLA 2256 + E+ + V+ L +L+ K++ + ++ E + L+K DD E A Sbjct: 243 LKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSE----A 298 Query: 2257 IKESDAMSTQDQHVLF---GKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKN 2313 + ++ H L G+ + IQ+ +E++Q +Q+ K + KI K +E N Sbjct: 299 KSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEK-EMLEKIGRLEKELENAN 357 Query: 2314 ELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEA 2373 +L+ + + L ++ + ++ + KL EL N +T E Sbjct: 358 DLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKL-TELYNAYVETQDQLLLEKLEN 416 Query: 2374 DSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVE 2433 + LD ++ E A ++ EE + + + K+ Q +E+ L+ + + Sbjct: 417 KRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKAN 476 Query: 2434 KIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFE-ENGKGSIINLETR 2492 K S+ L +D +E+ +K L Q E E +G+ + + Sbjct: 477 KQSSV-----------LERDNRRMEI-----QVKDLSQQIRVLLMELEEARGNHVIRDEE 520 Query: 2493 LLQLESTVSAKDL-ELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQI 2551 + + + S++ + + Y+ I+++Q+Q Q + +++ ++ E++ ++ ++++ Sbjct: 521 VSSADISSSSEVISQHLVSYRNIEELQQQNQ-RLLVALRELGETREREEQETTSSKITEL 579 Query: 2552 QLEAVQEYAKFCQ-------DNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELE 2604 QL+ + Q Q + S + ++ + + + + A +L L Sbjct: 580 QLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLA 639 Query: 2605 SQVVEMHTS-LILEKEQVEIAEK-NVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVE 2662 S TS + V + E +E + L +LQ++ E +K++ E EK ++ Q + Sbjct: 640 STPKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEK 699 Query: 2663 VLKTTTELFHSNEESGFFNELEALRAESV-----ATKAELASYKEKAEKLQEELLVKETN 2717 + + T+L N + + + R E + + E+ S E+ +KL +E Sbjct: 700 LQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQI 759 Query: 2718 MTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLS---KSIASQT 2774 + ++ +DL + LA A+ + L+KE E M + ++LS +S+ ++ Sbjct: 760 INTMTQDLRGANEKLAVAEVRAENLKKEKE----------MLKLSEVRLSQQRESLLAEQ 809 Query: 2775 DGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTEIISQFTEKIE-KMQELHA----A 2829 G + ++ QT Q +++ + + + E++ IS +K+E ++++ H Sbjct: 810 RGQNLLLTNLQTIQGILERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNL 869 Query: 2830 EILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQT 2889 ++ ++++ +TET H +LLK + + Q L + E Sbjct: 870 DVQLLDTKRQLDTET--NLHLNTKELLKNAQKEIATLKQHLSNMEVQ------------- 914 Query: 2890 REICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQV 2949 +S S G+G D+ S+ R ++E + +++K V V Sbjct: 915 ---VASQSSQRTGKGQPSNKEDVDDLVSQLR--QTEEQVNDLKERLKTSTSNVEQYQAMV 969 Query: 2950 LSLTESPYSDGEDHSIQQVSEPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHE 3009 SL ES + +QV+E E RK N LK+ + Q Q E ++ + + + Sbjct: 970 TSLEESLNKE------KQVTE---EVRK---NIEVRLKE-SAEFQTQLEKKLMEVEKEKQ 1016 Query: 3010 SFSDWRGELLLALQQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQR--IQEQGVEY 3067 D + + +++Q L E L++ + E+ + L N + R QEQ Sbjct: 1017 ELQDDKRRAIESMEQQ-LSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQA--- 1072 Query: 3068 QAAMECLQKADRRSLL--SEIQALHA--QMNGRKITLKR--EQESEKPSQELLEYNIQ-- 3119 + A+E K +R +L ++++AL A + + ++++ E+ ++K +LLE Sbjct: 1073 KIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWE 1132 Query: 3120 --------------------QKQSQMLEMQVE------LSSMKDRA-----TELQEQLSS 3148 +KQ+++L Q+E ++S+K+ L E+ S Sbjct: 1133 ERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKS 1192 Query: 3149 EKMVVAELK-----SELAQTKLELETTLKAQHKHL-----KELEAFRLEVKDKTDEVHLL 3198 ++ ++ L+ E+A+T+ E+ +++ +EL+ + + + ++V + Sbjct: 1193 QEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAEREKVQVT 1252 Query: 3199 NDTLASEQ---KKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLL- 3254 T+A + KK+ + +E K L +ER +++L+ ++ K R L+L++L Sbjct: 1253 AKTMAQHEELMKKTETMNVVMETNK-MLREEKERLEQDLQQMQ-----AKVRKLELDILP 1306 Query: 3255 LEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNL------------ELQVLLESEKV--- 3299 L++ L+E +++++ L + + + RN E + LL ++V Sbjct: 1307 LQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTK 1366 Query: 3300 RIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLK------ELQKQL-------EE 3346 RI++++ + R + A+ +S Q+ EDL K +QK L +E Sbjct: 1367 RIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQE 1426 Query: 3347 KHSRIVELLNETEKYKLDSLQTRQQMEK-------------DRQVHRKTLQTEQEANTEG 3393 K I ++ +YK + + Q +K ++ V + +Q +E + Sbjct: 1427 KVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQA 1486 Query: 3394 QKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELEREEKRESRRILY 3453 + K L+S+VE+LQ+ L EK + L + +LQ + ++ +R + E R Sbjct: 1487 ETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQI 1546 Query: 3454 QNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEM----IRQ 3509 E T ++ + +++ L + TKE+ +L + NG EL++ ++ Sbjct: 1547 TEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENE--ELKQRNGALDQQKDELDVRITALKS 1604 Query: 3510 KLQCVASKLQVLPQKASER-LQFETADDEDFIWVQENIDEIILQLQKLTGQQG 3561 + + S+L+ ++ ER L+ E V E +I L+ +G++G Sbjct: 1605 QYEGRISRLERELREHQERHLEQRDEPQEPSNKVPEQQRQITLKTTPASGERG 1657 Score = 167 bits (422), Expect = 2e-40 Identities = 358/1716 (20%), Positives = 717/1716 (41%), Gaps = 255/1716 (14%) Query: 1838 ENEELMLNISSRLQAAVEKLLEAISETSS-QLEHAKVT-QTELMRESFRQKQEA------ 1889 E+E+ I RL + E+L+ E S +LE K+ Q + + E ++ + A Sbjct: 49 ESEQQYFEIEKRLSHSQERLVNETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIA 108 Query: 1890 --TESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDR 1947 ++ + +EEL + R E+L+ EL Y E +++ EK + Sbjct: 109 IQSQFTRTKEELEAEKRDLIRTNERLSQELE--------YLTEDV---KRLNEKLKESNT 157 Query: 1948 LEQELLCASNRLQ----ELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMK 2003 + EL + LQ ++ ++++++E+ELL Q + E +LL + Sbjct: 158 TKGELQLKLDELQASDVSVKYREKRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGN 217 Query: 2004 EKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLE 2063 E LE++C E + +E+VSR LE++ N L+ N+ L+K +E Sbjct: 218 EILELKCNLE---------------NKKEEVSR---LEEQMN----GLKTSNEHLQKHVE 255 Query: 2064 ----KMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLK 2119 K+++ ++QA E + I+ + S TR VE+L LK Sbjct: 256 DLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLK 315 Query: 2120 EK-------TDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQAL-LVEDRKHFGAV 2171 E D E+ SK+Q+++++ E+ +EK ELE A L+ K GA+ Sbjct: 316 EAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEK------ELENANDLLSATKRKGAI 369 Query: 2172 EAKPELSLEVQLQAERDAIDRKEKEITNL-----EEQLEQFREELENK--NEEVQQLHMQ 2224 ++ EL+ A I + ++T L E Q + E+LENK N+ + ++ + Sbjct: 370 LSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRINKYLDEIVKE 429 Query: 2225 LEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQ---- 2280 +E + + +E E+ K KL A+KE + Q+ K + +++ Sbjct: 430 VEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRL--QEDTDKANKQSSVLERDNR 487 Query: 2281 EKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEE 2340 E+++ L++Q+ L +L+ N VI ++ D+ + E + Q V EE Sbjct: 488 RMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVI--SQHLVSYRNIEE 545 Query: 2341 IEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEE 2400 ++Q N+ + +EL ++ + S + L+ +L+ + E LEQ ++ + Sbjct: 546 LQQQNQRLLVALRELGETREREEQ--ETTSSKITELQLKLESALTE---LEQLRKSRQHQ 600 Query: 2401 MTFMKNVLKETNFKMNQLTQ------ELFSLKRERESVEKIQSIPENSVNVAIDHLSKDK 2454 M + +++++ + L+Q L + + S+ P S V+ Sbjct: 601 MQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVI 660 Query: 2455 PELEVVLTEDALKSLEN--QTYFKSFEENGK---GSIINLETRLLQLES---------TV 2500 E + + ALK L+ + Y K EN K + L+ ++ L S Sbjct: 661 ESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQLDF 720 Query: 2501 SAKDLELTQ-----CYKQIKDMQEQGQFETEMLQK--KIVNLQ----KIVEEKVAAALVS 2549 ++K E+ Q ++I + E+ Q T QK +I+N + EK+A A V Sbjct: 721 ASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVR 780 Query: 2550 QIQLEAVQEYAK-----FCQDNQTISSEPE-----RTNIQNLNQLREDELGSDISALTLR 2599 L+ +E K Q +++ +E TN+Q + + E L+ + Sbjct: 781 AENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQ 840 Query: 2600 ISELESQVVEMHTSLILEKEQVEIAEKN----VLEKEKKL-------LELQKLLEGNEKK 2648 I +LE ++ + L E EQ +N +L+ +++L L ++LL+ +K+ Sbjct: 841 IEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKE 900 Query: 2649 QREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQ 2708 ++ S +V+V +++ + S +++ L ++ T+ ++ KE+ + Sbjct: 901 IATLKQHLSNMEVQVASQSSQRTGKGQPSN-KEDVDDLVSQLRQTEEQVNDLKERLKTST 959 Query: 2709 EELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKED-ETEVQESKKACMFEPLPIKLS 2767 + + +TSL++ L++ + E ++ + + KE E + Q KK E +L Sbjct: 960 SNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQ 1019 Query: 2768 -------KSIASQTDGTLKISSS--NQTPQILVK-NAGIQINLQSECSSEEVTEIISQFT 2817 +S+ Q K SS N+ + L + + + Q+ +E +I + Sbjct: 1020 DDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAKIAVEAQ 1079 Query: 2818 EKIEKMQELHAAEILDMES------------RHISETETLKREHYV---------AVQLL 2856 K E+ LHAA++ +++ +H+ ET T K E + ++L Sbjct: 1080 NKYERELMLHAADVEALQAAKEQVSKMASVRQHLEET-TQKAESQLLECKASWEERERML 1138 Query: 2857 KEECGTLKAVIQCLRSKEGSSIPELAHS--DAYQTREICSSDSGSDWGQGIYLTHSQGFD 2914 K+E K V +C ++ L H + + + S G + Sbjct: 1139 KDEVS--KCVCRC---EDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNV--------S 1185 Query: 2915 IASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLE 2974 ++ EG+ +E F ++ K + E QV SL + + +Q++ + Sbjct: 1186 LSEEGKSQEQILEILRFIRREKEIAE-TRFEVAQVESLRYRQRVELLERELQELQDSLNA 1244 Query: 2975 ERKAYINTISSLKDLITKMQLQREAEVYD-SSQSHESFSDWRGELLLALQQVFLEERSVL 3033 ER+ T K + +L ++ E + ++++ + + L LQQ+ + R Sbjct: 1245 EREKVQVT---AKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVR--- 1298 Query: 3034 LAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQM 3093 + EL L +QE E LQ A+++ L +++ A+ Sbjct: 1299 ----KLELDIL--------------PLQEANAELSEKSGMLQ-AEKKLLEEDVKRWKAR- 1338 Query: 3094 NGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVV 3153 N ++ +++ ++E+ + L E + K+ Q ++ E+ +K L++ + ++ Sbjct: 1339 NQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQ--QLTEEIGRLKAEIARSNASLTNNQNLI 1396 Query: 3154 AELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQ 3213 LK +L + + E ET K+L+A +++++K T+ +K R + Sbjct: 1397 QSLKEDLNKVRTEKETI-------QKDLDAKIIDIQEKV-------KTITQVKKIGRRYK 1442 Query: 3214 WALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQK---IE 3270 E+ KA+ + E + D + S ++ +++ K+ LN+++ K +E Sbjct: 1443 TQYEELKAQQDKVMETSAQSSGDHQEQHVSVQE--------MQELKETLNQAETKSKSLE 1494 Query: 3271 SQRMLYDAQLSEE--QGRNLELQ-VLLESEKVRIR-EMSSTLDRERELHAQL-QSSDGTG 3325 SQ LSE+ + RNL+ Q V L+SE R+R ++ +E +L Q+ + + T Sbjct: 1495 SQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKEEKTR 1554 Query: 3326 QSRPPLPSE-----DLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHR 3380 ++ S+ + +L K+ EE R L + +K +LD T + + + ++ R Sbjct: 1555 KAIVAAKSKIAHLAGVKDQLTKENEELKQRNGAL--DQQKDELDVRITALKSQYEGRISR 1612 Query: 3381 --KTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEK 3414 + L+ QE + E + + E +KV + QRQ+ K Sbjct: 1613 LERELREHQERHLEQRDEPQEPSNKVPEQQRQITLK 1648 Score = 160 bits (405), Expect = 2e-38 Identities = 363/1773 (20%), Positives = 715/1773 (40%), Gaps = 284/1773 (16%) Query: 694 QLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILR-QEEKEKGTLEQEVQELQLKT 752 Q +LE ++L L +S+ N + + Q Q EI+ L+ + EK K EQ+ E++ + Sbjct: 6 QQVLERTELNKLPKSVQNKLEKFLADQ----QSEIDGLKGRHEKFKVESEQQYFEIEKRL 61 Query: 753 ELLEKQMKEKENDLQEKFAQLEAENSILK---DEKKTLEDMLKIHTPVSQEERLIFLDSI 809 ++++ + + Q +LE N+ LK ++ K LE ++R I + S Sbjct: 62 SHSQERLVNETRECQSLRLELEKLNNQLKALTEKNKELE---------IAQDRNIAIQSQ 112 Query: 810 KSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYA 869 +++K+ + E E LI NE L Q+ L E++++ K ELQ Sbjct: 113 FTRTKEEL-EAEKRDLIRTNERLSQELEYLTEDVKRLNEKL----KESNTTKGELQ---- 163 Query: 870 CLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLE 929 LK+ D+L+ S ++ K + K L +E L T + E KT E L Sbjct: 164 --LKL-DELQAS----DVSVKYREKRLEQEKELLHSQNTWLNT------ELKTKTDELLA 210 Query: 930 MGEVVEKDTTELMEKLEVTKREKLELSQRLSDL--SEQLKQKHGEISFLNEEVKSLKQEK 987 +G + EL LE K E L ++++ L S + QKH E + + LK+ K Sbjct: 211 LGREKGNEILELKCNLENKKEEVSRLEEQMNGLKTSNEHLQKHVE-----DLLTKLKEAK 265 Query: 988 EQVSLRCRELEIIIN-HNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEES 1046 EQ + + +N H + N+ S +T A + K+ K GE + Sbjct: 266 EQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNELTR----AVEELHKLLKEAGEAN 321 Query: 1047 KIMVEDKVSFENMTVGEESKQEQLI---------LDHLPSVTK-------ESSLRATQPS 1090 K + + + E E + + I + L S TK E L A P+ Sbjct: 322 KAIQDHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPT 381 Query: 1091 E---------NDKLQKELNVLKSEQNDLRLQ-MEAQRICLSLVYSTHVDQVREYMENEKD 1140 KL + N Q+ L L+ +E +RI + ++D++ + +E K Sbjct: 382 AAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRI------NKYLDEIVKEVE-AKA 434 Query: 1141 KALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQ-------K 1193 L +EE AQ+ K+ Q + + QE D+ ++ + K Sbjct: 435 PILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVK 494 Query: 1194 AVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISEN-------EDPELQDYR 1246 +S++ L L G + EV++ D +S + IS++ E+ + Q+ R Sbjct: 495 DLSQQIRVLLMELEEARGNHVIRDE--EVSSADISSSSEVISQHLVSYRNIEELQQQNQR 552 Query: 1247 YEVQ-------DFQENMHTLLNKVTEEYNKL-----------------------LVLQTR 1276 V +E T +K+TE KL +V Q Sbjct: 553 LLVALRELGETREREEQETTSSKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRD 612 Query: 1277 LSKIWGQQTDGMKLEFGEENL--------PK-----------------EETEFLSIHSQM 1311 + +I QT G+ + +L PK E TE + + + Sbjct: 613 MYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEAIEAKAAL 672 Query: 1312 TNLEDIDVNHKSKLSS---LQDLEKTKLEEQVQELES----------LISSLQQQLKETE 1358 L++I N+K + + +Q+ + KL+EQV +L S S + L++ Sbjct: 673 KQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNV 732 Query: 1359 QNYEAEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSG 1418 + Y EI L +R Q ++ +T ++++ A + +N+ Sbjct: 733 EGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAENL-------- 784 Query: 1419 EFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISG--GKENTASSKQ 1476 K+E ++KL E + +Q E +A+ + T L I G + T + ++ Sbjct: 785 ----KKEKEMLKLSEVRLSQQRESLLAEQRGQNLLL----TNLQTIQGILERSETETKQR 836 Query: 1477 AHAVCQQEQHYFNEMKLSQDQIGFQTF---ETVDVKFKEEFKPLSKELGEHGKEILLSNS 1533 + ++ +H + +K + Q +DV+ + + L E H L + Sbjct: 837 LSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKN 896 Query: 1534 DPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQE 1593 +I K + + ++ S+ + ++ V D QL EEQ+ D+++ Sbjct: 897 AQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVD--DLVSQLRQTEEQVNDLKER 954 Query: 1594 LVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIK-----RLNRQLAQRSSIDNENL 1648 L +Q QA + +E ++Q+ EE++ RL ++ ++ + + Sbjct: 955 LKTSTSNVEQ-----YQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLM 1009 Query: 1649 VSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQTFKEKELDRK 1708 E+E+ +EL+ K+ ++ E+ EL+ + + QN EV+E + Sbjct: 1010 EVEKEK---QELQDDKRRAIESMEQQLSELKKTLSSVQN------EVQEALQRASTALSN 1060 Query: 1709 PEDVPPEILSNERYALQKANNRLLKILLEV--VKTTAAVEETIGRHVLGILDRSSKSQSS 1766 + + + A++ N +++L V+ A +E + + +S Q Sbjct: 1061 EQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSK-------MASVRQHL 1113 Query: 1767 ASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTE-LSQRL 1825 ++E++ EE R+ + + S D+ +++ + E LS ++ Sbjct: 1114 EETTQKAESQLLECKASWEERERMLKDEV---SKCVCRCEDLEKQNRLLHDQIEKLSDKV 1170 Query: 1826 VRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQ 1885 V S G + P N L S + E++LE + + E A+ ES R Sbjct: 1171 VASVKEGVQ-GPLNVSL-----SEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRY 1224 Query: 1886 KQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFE--RQIQEKTD 1943 +Q + +EL++ L+ E + A +++ E ++ + E + ++E+ Sbjct: 1225 RQRVELLERELQELQDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEK- 1283 Query: 1944 IIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMK 2003 +RLEQ+L ++++LE + +QE LS + ++A E++LL+E K K Sbjct: 1284 --ERLEQDLQQMQAKVRKLELDILPLQEANAELSEKSGMLQA-----EKKLLEEDVKRWK 1336 Query: 2004 EKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQAL---EK 2060 + + +K D ++ + L + E R +L +E ++ + N +L + Sbjct: 1337 ARNQHLVSQQK--DPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQN 1394 Query: 2061 QLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKE 2120 ++ +++ L++ ++E + +I +++++K + + + I + E+ LK Sbjct: 1395 LIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEE----LKA 1450 Query: 2121 KTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVEDRKHFGAVEAKPELSLE 2180 + DK E + Q D QE++ +++++ L QA E K + SLE Sbjct: 1451 QQDKVME---TSAQSSGDHQEQHVSVQEMQELKETLNQA------------ETKSK-SLE 1494 Query: 2181 VQLQAERDAIDRKEKEITNLEEQ-------LEQFREELENKNEEVQQLHMQLEIQKKEST 2233 Q++ + + KE E NL+EQ L + R++L+++ + +QL Q I +KE Sbjct: 1495 SQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQ--ITEKEEK 1552 Query: 2234 TRLQELEQENKL-----FKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQ 2288 TR + ++K+ KD + K +K+ + Q + L + + + E I + Sbjct: 1553 TRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQQKDELDVRITALKSQYEGRISR 1612 Query: 2289 LNEQVTKLQQQLKITTD------NKVIEEKNEL 2315 L ++ + Q++ D NKV E++ ++ Sbjct: 1613 LERELREHQERHLEQRDEPQEPSNKVPEQQRQI 1645 Score = 152 bits (384), Expect = 6e-36 Identities = 327/1672 (19%), Positives = 668/1672 (39%), Gaps = 235/1672 (14%) Query: 1319 VNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSES 1378 V +++L+ L + KLE+ + + +S I L+ + ++ + E + ++KRL E Sbjct: 8 VLERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQER 67 Query: 1379 TVPPSLPVDSVVITESDAQRTMYPGSCVKKNI----DGTIEFSGEF-GVKEETNIVKLLE 1433 V + S+ + + + K + D I +F KEE K Sbjct: 68 LVNETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDL 127 Query: 1434 KQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAH--AVCQQEQHYFNEM 1491 + E+L +E+ + + + E + G + QA +V +E+ E Sbjct: 128 IRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQEK 187 Query: 1492 KLSQDQIGFQTFETVDVKFK-EEFKPLSKELG----------EHGKEIL---------LS 1531 +L Q T+ ++K K +E L +E G E+ KE + L Sbjct: 188 ELLHSQ---NTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQMNGLK 244 Query: 1532 NSDPHDIPESKDCVLTI---SEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLE 1588 S+ H +D + + E+ S ++ F + H ++S A+ +L Sbjct: 245 TSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNELT 304 Query: 1589 DMRQELVRQYQEHQQATELLRQAHMRQMERQREDQE-QLQEEIKRLNRQLAQRSSIDNEN 1647 +EL + +E +A + + Q H+ ++E+ ++ E ++ E+I RL ++L + + + Sbjct: 305 RAVEELHKLLKEAGEANKAI-QDHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLS-- 361 Query: 1648 LVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGN-ENQGEVEEQTFKEKELD 1706 ++R+ +L E E A + T+ N E Q ++ + + K ++ Sbjct: 362 -ATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRIN 420 Query: 1707 RKPEDVPPE------ILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRS 1760 + +++ E IL +R ++A + + VK A++E + + + + Sbjct: 421 KYLDEIVKEVEAKAPILKRQREEYERAQKAVASL---SVKLEQAMKE-----IQRLQEDT 472 Query: 1761 SKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTE 1820 K+ +S++ R ++ + RV + G+ + R++ + ++ Sbjct: 473 DKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSEV 532 Query: 1821 LSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMR 1880 +SQ LV N E + + RL A+ +L E + +K+T+ +L Sbjct: 533 ISQHLV---------SYRNIEELQQQNQRLLVALRELGETREREEQETTSSKITELQLKL 583 Query: 1881 ESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVI----DGYADEKTLFER 1936 ES E + K ++ + + R R+ + LS+ GV D+ +L Sbjct: 584 ES--ALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLAST 641 Query: 1937 QIQEKT-DIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLL 1995 + T + + S E +A +Q+QE E ++ KAE ++ + L Sbjct: 642 PKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKE----KAENEKIQNEQL 697 Query: 1996 QETEKLMKEKLEVQCQAEKVRDDL---QKQVKALEIDVEEQVSRFIEL------------ 2040 EKL ++ +++ Q K+ L K+ + L+ +VE L Sbjct: 698 ---EKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQ 754 Query: 2041 --EQEKNTELMDLRQQNQAL------EKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQ 2092 EQ NT DLR N+ L + L+K ++ L + +R+ E + Sbjct: 755 KQEQIINTMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNL 814 Query: 2093 QLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFR 2152 L + Q I E E +Q + EK + E+ K++L+ ++++R+ L+ + Sbjct: 815 LLTNLQTIQGILERSETETKQRLSSQIEKLE--HEISHLKKKLENEVEQRHTLTRNLDVQ 872 Query: 2153 VRELEQALLVEDRKHFGAVE----AKPEL--------SLEVQLQAERDAIDRK-----EK 2195 + + ++ L E H E A+ E+ ++EVQ+ ++ K ++ Sbjct: 873 LLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKE 932 Query: 2196 EITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGL 2255 ++ +L QL Q E++ + E ++ +E + T+ + L +E ++ ++ + + + Sbjct: 933 DVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEV 992 Query: 2256 AIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNEL 2315 +KES TQ L K ++ +EK+ D + ++QQL + K + Sbjct: 993 RLKESAEFQTQ----LEKKLMEVEKEKQELQDDKRRAIESMEQQL--SELKKTLSSVQNE 1046 Query: 2316 IRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEA-D 2374 +++ + +S+++ +R+ +E+ + E K ++EL H+ EA Sbjct: 1047 VQEALQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELM---------LHAADVEALQ 1097 Query: 2375 SLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEK 2434 + K Q+ + + + LE+ + A ++ K +E + L E+ E +EK Sbjct: 1098 AAKEQVSKMASVRQHLEETTQKAESQLLECKASWEE---RERMLKDEVSKCVCRCEDLEK 1154 Query: 2435 IQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLE-TRL 2493 + + + D + V ++ ++ N S E GK LE R Sbjct: 1155 QNRLLHDQIEKLSDKV--------VASVKEGVQGPLN----VSLSEEGKSQEQILEILRF 1202 Query: 2494 LQLESTVSAKDLELTQC----YKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVS 2549 ++ E ++ E+ Q Y+Q E+L++++ LQ + Sbjct: 1203 IRREKEIAETRFEVAQVESLRYRQ----------RVELLERELQELQDSL---------- 1242 Query: 2550 QIQLEAVQEYAKFCQDNQTISSEPERTNI--QNLNQLREDE--LGSDISALTLRISELES 2605 + E VQ AK ++ + + E N+ + LRE++ L D+ + ++ +LE Sbjct: 1243 NAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLEL 1302 Query: 2606 QVVEMHTSLILEKEQVEIAEKN-VLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVL 2664 + L L++ E++EK+ +L+ EKKLLE + + + Q +++ P E Sbjct: 1303 DI------LPLQEANAELSEKSGMLQAEKKLLE-EDVKRWKARNQHLVSQQKDPDTEEYR 1355 Query: 2665 KTTTEL-FHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQK 2723 K +E H+ E+ L+AE + A L + + + L+E+L T ++QK Sbjct: 1356 KLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQK 1415 Query: 2724 DL--------------SQVR-----------------DHLAEAKEKLSILEKEDETEVQE 2752 DL +QV+ D + E + S +E VQE Sbjct: 1416 DLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQE 1475 Query: 2753 SKKACMFEPLPIKLSKSIASQTDGTLKISS---------SNQTPQILVKNAGIQINLQSE 2803 ++ SKS+ SQ + K S QT Q+ + + ++ +LQ Sbjct: 1476 MQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDLQDR 1535 Query: 2804 CSSEEVTEIISQFTEKIEKMQEL------HAAEILDMESRHISETETLKREH 2849 + EE ++ Q TEK EK ++ A + ++ + E E LK+ + Sbjct: 1536 TTQEE--QLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQRN 1585 Score = 152 bits (384), Expect = 6e-36 Identities = 381/1825 (20%), Positives = 747/1825 (40%), Gaps = 326/1825 (17%) Query: 554 QESKLNEAHKSLST-----VEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKN 608 + ++LN+ KS+ + D ++EI + R E + K E+E ++I+ + ++ Sbjct: 10 ERTELNKLPKSVQNKLEKFLADQQSEI-DGLKGRHE-KFKVESEQQYFEIEKRLSHSQER 67 Query: 609 AVLD-RMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQI 667 V + R +S ELE+L QL + L++ ++LEI NI Sbjct: 68 LVNETRECQSLRLELEKLNNQL-----KALTEKNKELEIAQDRNI--------------- 107 Query: 668 DGLQNEMSQKIETMQFEKDNLITKQNQLILEISKL----KDLQQSLVNSKSE--EMTLQI 721 +Q++ ++ E ++ EK +LI +L E+ L K L + L S + E+ L++ Sbjct: 108 -AIQSQFTRTKEELEAEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKL 166 Query: 722 NELQKEIEILRQEEKEKGTLEQEVQ-----------ELQLKTELLEKQMKEKENDLQEKF 770 +ELQ ++ EK LEQE + EL+ KT+ L +EK N++ E Sbjct: 167 DELQASDVSVKYREKR---LEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELK 223 Query: 771 AQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENE 830 LE + K+E LE+ + K+ + +K +E L+ + + Sbjct: 224 CNLENK----KEEVSRLEEQMN-----------------GLKTSNEHLQKHVEDLLTKLK 262 Query: 831 DLKQQCIQLNEEIE-------KQRNTFSFAEKNFEVNYQELQ---EEYACLLK------- 873 + K+Q + E+ K N + A + E EL EE LLK Sbjct: 263 EAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANK 322 Query: 874 -VKDDL---EDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLE 929 ++D L E SK++ E E K+ L +EL + K K ++ E++ +A Sbjct: 323 AIQDHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSATKRKGAILSEEE--LAAMSP 380 Query: 930 MGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQ 989 V K M KL +E +L L E+L+ K +L+E VK + + K Sbjct: 381 TAAAVAKIVKPGM-KLTELYNAYVETQDQL--LLEKLENKRIN-KYLDEIVKEV-EAKAP 435 Query: 990 VSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIM 1049 + R RE E Q +S L+ + R E + K NK +S ++ Sbjct: 436 ILKRQRE--------EYERAQKAVASLSVKLEQAMKEIQRLQEDT-DKANK----QSSVL 482 Query: 1050 VEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNV---LKSEQ 1106 D E + V + S+Q +++L L +R + S D + L S + Sbjct: 483 ERDNRRME-IQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVISQHLVSYR 541 Query: 1107 NDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKI-- 1164 N LQ + QR+ ++L ++ E E E+ + S EL E + EL+++ Sbjct: 542 NIEELQQQNQRLLVAL------RELGETREREEQETTSSKITELQLKLESALTELEQLRK 595 Query: 1165 ---HQLEL-----------QTMKTQETGDEGKPLHLL-IGKLQKAVSEECSYFLQTLCSV 1209 HQ++L + + +Q TG PLH + + A + + QT+ Sbjct: 596 SRQHQMQLVDSIVRQRDMYRILLSQTTG-VAIPLHASSLDDVSLASTPKRPSTSQTVS-- 652 Query: 1210 LGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNK 1269 TPA + + + + + + ++ ++Y+ E + ++ + L K+ E+ Sbjct: 653 -----TPAPVPVIESTEAIEAKAALKQLQEI-FENYKKEKAENEKIQNEQLEKLQEQVTD 706 Query: 1270 LLVLQTRLSKIWGQQTD--GMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSS 1327 L T++S Q D + E ++N+ E S+H + L + +++ Sbjct: 707 LRSQNTKIST----QLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINT 762 Query: 1328 L-QDL--------------EKTKLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRL 1372 + QDL E K E+++ +L + S Q++ EQ + + + + Sbjct: 763 MTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTI 822 Query: 1373 QAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIE-------------FSGE 1419 Q + E + ++ S ++ + S +KK ++ +E + Sbjct: 823 QGILERS-----ETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTK 877 Query: 1420 FGVKEETNIVKLLEKQYQEQLEEEVAKV---IVSMSIAFAQQTELSRISGGKENTASSKQ 1476 + ETN+ L K+ + ++E+A + + +M + A Q+ G N Sbjct: 878 RQLDTETNL-HLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDD 936 Query: 1477 AHAVCQQEQHYFNEMK--LSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSD 1534 + +Q + N++K L + ++ + +E + E K I + Sbjct: 937 LVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVR--- 993 Query: 1535 PHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQEL 1594 + ES + + +++ +K +Q + D D R + E+QL ++++ L Sbjct: 994 ---LKESAEFQTQLEKKLMEVEKE---KQELQD-------DKRRAIESMEQQLSELKKTL 1040 Query: 1595 VRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERER 1654 E Q+A + A + + +R+ QEQ + ++ N+ ERE Sbjct: 1041 SSVQNEVQEALQRASTALSNEQQARRDCQEQAKIAVEAQNKY--------------EREL 1086 Query: 1655 VL-LEELEALKQLSLAGREKL--CCELRNSSTQTQNGNENQGEVEEQTFKEKELDRKPED 1711 +L ++EAL+ A +E++ +R +T E+Q + +++E+E K ++ Sbjct: 1087 MLHAADVEALQ----AAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERERMLK-DE 1141 Query: 1712 VPPEILSNERYALQKANNRLLKILLEVV--KTTAAVEETIGRHVLGILDRSSKSQSSASL 1769 V + E Q NRLL +E + K A+V+E + + L KSQ Sbjct: 1142 VSKCVCRCEDLEKQ---NRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILE 1198 Query: 1770 IW---RSEAE--------ASVKSCVHEEHTRVTDESIPSYSGS-DMPRNDINMWSKVTEE 1817 I R E E A V+S + + + + + S + R + + +K + Sbjct: 1199 ILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAEREKVQVTAKTMAQ 1258 Query: 1818 GTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTE 1877 EL ++ E +++ + L+ E+L E Q AKV + E Sbjct: 1259 HEELMKK------------TETMNVVMETNKMLREEKERL-----EQDLQQMQAKVRKLE 1301 Query: 1878 L----MRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVID--GYADEK 1931 L ++E+ + E + L+ +++L E + +AR Q V K + EK Sbjct: 1302 LDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEK 1361 Query: 1932 TLFERQIQEKTDIIDRLEQELLCAS-------NRLQELEAEQQQIQEERELLSRQKEAMK 1984 + ++IQ+ T+ I RL+ E+ ++ N +Q L+ + +++ E+E + + +A Sbjct: 1362 EVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKI 1421 Query: 1985 AEAGPVEQQLLQETE-KLMKEKLEVQCQAEKVRDDLQKQVKALEI-DVEEQVSRFIELEQ 2042 + +++++ T+ K + + + Q + K + D + A D +EQ E+++ Sbjct: 1422 ID---IQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQE 1478 Query: 2043 EKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQP 2102 K T L ++++LE Q+E ++K L E +E E Q++ +L+ Sbjct: 1479 LKET-LNQAETKSKSLESQVENLQKTLSE----KETEARNLQEQTVQLQS---------- 1523 Query: 2103 ISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLV 2162 E+ +L L+++T + +EQL++ I E+ E+ K A++ Sbjct: 1524 -------ELSRLRQDLQDRTTQ-------EEQLRQQITEKEEKTRK----------AIVA 1559 Query: 2163 EDRKHFGAVEAKPELSLE-VQLQAERDAIDRKEKE----ITNLEEQLEQFREELENKNEE 2217 K K +L+ E +L+ A+D+++ E IT L+ Q E LE + E Sbjct: 1560 AKSKIAHLAGVKDQLTKENEELKQRNGALDQQKDELDVRITALKSQYEGRISRLERELRE 1619 Query: 2218 VQQLHMQLEIQKKESTTRLQELEQE 2242 Q+ H++ + +E + ++ E +++ Sbjct: 1620 HQERHLEQRDEPQEPSNKVPEQQRQ 1644 Score = 139 bits (350), Expect = 5e-32 Identities = 343/1771 (19%), Positives = 706/1771 (39%), Gaps = 301/1771 (16%) Query: 1509 KFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCV-LTISEEMFSKDKTFIVRQSIHD 1567 KFK E + E+ E LS+S + E+++C L + E + + ++ Sbjct: 45 KFKVESEQQYFEI-----EKRLSHSQERLVNETRECQSLRLELEKLNNQLKALTEKNKEL 99 Query: 1568 EISVS-SMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQL 1626 EI+ ++ Q +E+LE +++L+ R ER ++ E L Sbjct: 100 EIAQDRNIAIQSQFTRTKEELEAEKRDLI------------------RTNERLSQELEYL 141 Query: 1627 QEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQ 1686 E++KRLN +L + ++ E ++ L+EL+A +S+ REK E +Q Sbjct: 142 TEDVKRLNEKLKESNTTKGE------LQLKLDELQA-SDVSVKYREKR-LEQEKELLHSQ 193 Query: 1687 NGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVE 1746 N N E++ +T + L R+ + E+ N ++ + L+ + +KT+ Sbjct: 194 NTWLNT-ELKTKTDELLALGREKGNEILELKCNLENKKEEVSR--LEEQMNGLKTS---N 247 Query: 1747 ETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEE---HTRVTDESIPSYSGSDM 1803 E + +HV +L + +++ E +AS++ H E H ++++ + S+ Sbjct: 248 EHLQKHVEDLLTKLKEAK---------EQQASMEEKFHNELNAHIKLSNLYKSAADDSEA 298 Query: 1804 PRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISE 1863 N++ T EL + L +G A I ++ +L + +++LE I Sbjct: 299 KSNEL------TRAVEELHKLLKEAGEANKAI----QDHLLEVEQSKDQMEKEMLEKIGR 348 Query: 1864 TSSQLEHAKVTQTELMRESFRQKQE-----------ATESLKCQEELRERLHEESRAREQ 1912 +LE+A + R+ +E + +K +L E + ++Q Sbjct: 349 LEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQ 408 Query: 1913 LAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEE 1972 L +E + + I+ Y DE ++++ K I+ R +E A + L + +Q +E Sbjct: 409 LLLEKLENKR-INKYLDE---IVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKE 464 Query: 1973 RELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEE 2032 + L + ++ +E+ ++E+Q + DL +Q++ L +++EE Sbjct: 465 IQRLQEDTDKANKQSSVLERD---------NRRMEIQVK------DLSQQIRVLLMELEE 509 Query: 2033 QVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQ 2092 + ++E ++ D+ ++ + + L R +E+Q+ Q Sbjct: 510 ARGNHVIRDEEVSS--ADISSSSEVISQHLVSYRNI----------------EELQQQNQ 551 Query: 2093 QLKVVPRFQPISEHQTR-EVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEF 2151 +L V R + E + R E E ++ + E K L EQL++ Q + + ++ + Sbjct: 552 RLLVALR--ELGETREREEQETTSSKITELQLKLESALTELEQLRKSRQHQMQLVDSI-V 608 Query: 2152 RVRELEQALLVE-------------DRKHFGAVEAKPELSLEVQLQAERDAIDRKE---- 2194 R R++ + LL + D + +P S V A I+ E Sbjct: 609 RQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEAIEA 668 Query: 2195 -KEITNLEEQLEQF-REELEN---KNEEVQQLHMQ---LEIQKKESTTRLQELEQENKLF 2246 + L+E E + +E+ EN +NE++++L Q L Q + +T+L + ++ Sbjct: 669 KAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEML 728 Query: 2247 KDDMEKLGLAI------KESDAMSTQDQHVLFGKFAQIIQ---EKEVEIDQLNEQVTKLQ 2297 +D++E I + +TQ Q + Q ++ EK + E + K + Sbjct: 729 QDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAENLKKEK 788 Query: 2298 QQLKITTDNKVIEEKNELIRDLETQ---IECLMSDQECVKRNREEEIEQLNEVIEKLQQE 2354 + LK+ ++ ++ +++ L+ + Q + L + Q ++R+ E ++L+ IEKL+ E Sbjct: 789 EMLKL-SEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQIEKLEHE 847 Query: 2355 LANIGQKTSMNA---HSLSEEAD----SLKHQLDVVIAEKLALEQQVETANEEMTFMK-- 2405 ++++ +K H+L+ D K QLD L ++ ++ A +E+ +K Sbjct: 848 ISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQH 907 Query: 2406 -------------------------------NVLKETNFKMNQLTQELFSLKRERESVEK 2434 + L++T ++N L + L + E + Sbjct: 908 LSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQA 967 Query: 2435 IQSIPENSVNVAIDHLSKDKPELEVVLTEDA-------LKSLENQTYFKSFEENGKGSII 2487 + + E S+N + + +EV L E A K +E + + +++ + +I Sbjct: 968 MVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQDDKRRAIE 1027 Query: 2488 NLETRLLQLESTVSAKDLELTQCYKQIK---DMQEQGQFETEMLQKKIVNLQKIVEEKVA 2544 ++E +L +L+ T+S+ E+ + ++ ++Q + + + K V Q E ++ Sbjct: 1028 SMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELM 1087 Query: 2545 --AALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLN-----QLREDELGSDISALT 2597 AA V +Q A ++ +K Q + ++ Q L + RE L ++S Sbjct: 1088 LHAADVEALQ-AAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERERMLKDEVSKCV 1146 Query: 2598 LRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRS 2657 R +LE Q +H + ++V + K E + L + EG ++Q + + Sbjct: 1147 CRCEDLEKQNRLLHDQIEKLSDKVVASVK---EGVQGPLNVSLSEEGKSQEQILEILRFI 1203 Query: 2658 PQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAE-----KLQEELL 2712 ++ E+ +T E+ E + +E L E + L + +EK + Q E L Sbjct: 1204 RREKEIAETRFEVAQV-ESLRYRQRVELLERELQELQDSLNAEREKVQVTAKTMAQHEEL 1262 Query: 2713 VKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLSKSIAS 2772 +K+T ++ + +++ L E KE+L ++D ++Q + + LP++ + + S Sbjct: 1263 MKKTETMNVVMETNKM---LREEKERL----EQDLQQMQAKVRKLELDILPLQEANAELS 1315 Query: 2773 QTDGTLKISSSNQTPQILVKNAGIQ--INLQSECSSEEVTEIISQFTEKIEKMQELHAAE 2830 + G L+ + A Q ++ Q + +EE +++S+ Sbjct: 1316 EKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSE--------------- 1360 Query: 2831 ILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQT- 2889 K H +Q L EE G LKA E+A S+A T Sbjct: 1361 ---------------KEVHTKRIQQLTEEIGRLKA--------------EIARSNASLTN 1391 Query: 2890 REICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNE-GMQ 2948 + D + + D+ ++ + + T + KKI + + E Q Sbjct: 1392 NQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQ 1451 Query: 2949 VLSLTESPYSDGEDHSIQQVSEPWLEERKAYINTI----SSLKDLITKMQLQREAEVYDS 3004 + E+ DH Q VS ++E K +N SL+ + +Q + ++ Sbjct: 1452 QDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEA 1511 Query: 3005 SQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQG 3064 E + EL Q L++R+ R ++T ++ + G Sbjct: 1512 RNLQEQTVQLQSELSRLRQD--LQDRTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHLAG 1569 Query: 3065 VEYQAAMECLQKADRRSLLSE--------IQALHAQMNGRKITLKREQESEKPSQELLEY 3116 V+ Q E + R L + I AL +Q GR L+RE Sbjct: 1570 VKDQLTKENEELKQRNGALDQQKDELDVRITALKSQYEGRISRLERE------------- 1616 Query: 3117 NIQQKQSQMLEMQVELSSMKDRATELQEQLS 3147 +++ Q + LE + E ++ E Q Q++ Sbjct: 1617 -LREHQERHLEQRDEPQEPSNKVPEQQRQIT 1646 Score = 135 bits (340), Expect = 8e-31 Identities = 212/1010 (20%), Positives = 425/1010 (42%), Gaps = 145/1010 (14%) Query: 135 REEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHEIEELNRELEEMRVTYGTEGLQQLQ 194 R ++ EQ L +LA + E L +E E ++++ ++ Q Sbjct: 745 RNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSE----VRLSQ 800 Query: 195 EFEAAIKQRDGIITQLTANLQ--QARREKDETMREFLELTEQSQKLQIQFQQLQAS-ETL 251 + E+ + ++ G LT NLQ Q E+ ET + L+ Q +KL+ + L+ E Sbjct: 801 QRESLLAEQRGQNLLLT-NLQTIQGILERSETETK-QRLSSQIEKLEHEISHLKKKLENE 858 Query: 252 RNSTHSSTA---ADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVY 308 H+ T LL K+Q+ T LL++ QK+ +S ++ ++ Sbjct: 859 VEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQ 918 Query: 309 EMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQ 368 ++ K + SNKE+ +++L +++ + E++ +LK++L T+ + + Q + Sbjct: 919 SSQRTGKGQPSNKED-------VDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVT- 970 Query: 369 KNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQR 428 L S KE+Q +EE++ + ++ R + ++F+T + +++ Sbjct: 971 ----------SLEESLNKEKQVTEEVR------KNIEVRLKESAEFQTQLEKKL-----M 1009 Query: 429 KLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQI 488 ++E+ + EL + + I M+Q+L +++++ + + E++ AL+ S NE Q Sbjct: 1010 EVEKEKQELQDDKRRAIESMEQQL-----SELKKTLSSVQNEVQEALQRASTALSNEQQA 1064 Query: 489 KLMNVAINELNIKLQDTNSQKEKLK------EELGLILEEKCALQRQLEDLVEELSFSRE 542 + + I ++ N + +L E L E+ + + L E + Sbjct: 1065 R--RDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAES 1122 Query: 543 QIQRARQTIAEQESKL-NEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLE 601 Q+ + + E+E L +E K + EDL+ + + ++L K A V E Sbjct: 1123 QLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVK------E 1176 Query: 602 MLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGI 661 ++ N L +SQE LE LR E+E++ E R + +++ + Sbjct: 1177 GVQGPLNVSLSEEGKSQEQILEILR---FIRREKEIA--------ETRFEVAQVE---SL 1222 Query: 662 HYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQI 721 Y+Q+++ L+ E+ + +++ E++ ++++ Q + K+E M + + Sbjct: 1223 RYRQRVELLERELQELQDSLNAEREK---------VQVTAKTMAQHEELMKKTETMNVVM 1273 Query: 722 NELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILK 781 E + +EEKE+ LEQ++Q++Q K LE + LQE A+L ++ +L+ Sbjct: 1274 -----ETNKMLREEKER--LEQDLQQMQAKVRKLELDIL----PLQEANAELSEKSGMLQ 1322 Query: 782 DEKKTLEDMLKIHTP-----VSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLK--- 833 EKK LE+ +K VSQ++ + K S+ V K I+ L EE LK Sbjct: 1323 AEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEI 1382 Query: 834 ----------QQCIQ-LNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSK 882 Q IQ L E++ K R +K+ + ++QE+ + +VK K Sbjct: 1383 ARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYK 1442 Query: 883 NKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELM 942 + E +LKA +++ + + V ++ + ETL E K + Sbjct: 1443 TQYE-----ELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQAETKSKSLESQV 1497 Query: 943 EKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELE---- 998 E L+ T EK +L EQ Q E+S L ++++ ++EQ+ + E E Sbjct: 1498 ENLQKTLSEK---ETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKEEKTR 1554 Query: 999 --IIINHNRAENVQSCDTQVS-----------------SLLDGVVTMTSRGAEGSVSKVN 1039 I+ ++ ++ Q++ LD +T EG +S++ Sbjct: 1555 KAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQQKDELDVRITALKSQYEGRISRLE 1614 Query: 1040 KSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQP 1089 + E + +E + + + +Q Q+ L P+ + + P Sbjct: 1615 RELREHQERHLEQRDEPQEPSNKVPEQQRQITLKTTPASGERGIASTSDP 1664 Score = 129 bits (324), Expect = 6e-29 Identities = 314/1499 (20%), Positives = 619/1499 (41%), Gaps = 195/1499 (13%) Query: 2296 LQQQLKITTDNKV---IEEKNE-LIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKL 2351 LQQ L+ T NK+ ++ K E + D +++I+ L E K E++ ++ + + Sbjct: 5 LQQVLERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHS 64 Query: 2352 QQELANIGQKTSMNAHSLSEEADSLKHQL----------DVVIAEKLALEQQVETANEEM 2401 Q+ L N + SL E + L +QL ++ +A++ Q EE+ Sbjct: 65 QERLVN----ETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEEL 120 Query: 2402 TFMKNVLKETNFKMNQLTQELFSLKRERESVEKI-QSIPENSVNVAIDHLSKDKPELEVV 2460 K L TN +L+QEL L E V+++ + + E++ L D+ + V Sbjct: 121 EAEKRDLIRTN---ERLSQELEYLT---EDVKRLNEKLKESNTTKGELQLKLDELQASDV 174 Query: 2461 LTEDALKSLENQTYFKSFEENGKGSIINLET-RLLQLESTVSAKDLELTQCYKQIKDMQE 2519 + K LE + + + + +T LL L + LEL +C + K +E Sbjct: 175 SVKYREKRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILEL-KCNLENKK-EE 232 Query: 2520 QGQFETEMLQKKIVN--LQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTN 2577 + E +M K N LQK VE+ + ++ Q +++E KF + Sbjct: 233 VSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEE--KFHNELNA------HIK 284 Query: 2578 IQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLE 2637 + NL + D+ + + +EL V E+H L E + + ++LE E+ + Sbjct: 285 LSNLYKSAADDSEA-------KSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQ 337 Query: 2638 LQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAEL 2697 ++K E EK R +++ + D+ S EE + A A+ V +L Sbjct: 338 MEK--EMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKL 395 Query: 2698 ASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKAC 2757 + Q++LL+++ + K L ++ + E + K IL+++ E E + ++KA Sbjct: 396 TELYNAYVETQDQLLLEKLENKRINKYLDEI---VKEVEAKAPILKRQRE-EYERAQKAV 451 Query: 2758 MFEPLPIKLSKS------IASQTDGTLKISS----SNQTPQILVKNAGIQIN-LQSECSS 2806 L +KL ++ + TD K SS N+ +I VK+ QI L E Sbjct: 452 A--SLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEE 509 Query: 2807 EEVTEIISQFTEKIEKMQELHAAEILD---MESRHISETETLKREHYVAVQLL-----KE 2858 +I E++ ++E++ + R+I E + + VA++ L +E Sbjct: 510 ARGNHVIRD--EEVSSADISSSSEVISQHLVSYRNIEELQQQNQRLLVALRELGETRERE 567 Query: 2859 ECGTLKAVIQCLRSKEGSSIPELAH---SDAYQTREICSSDSGSDWGQGIYLTHSQGFDI 2915 E T + I L+ K S++ EL S +Q + + S D + I L+ + G I Sbjct: 568 EQETTSSKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYR-ILLSQTTGVAI 626 Query: 2916 ASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEE 2975 + S S PK+ + V+ TE+ + +Q++ E + +E Sbjct: 627 PLHASSLDDVSLA-STPKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKE 685 Query: 2976 RKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLA 3035 + + I QL++ E +S + ++ Q F +R +L Sbjct: 686 KAE--------NEKIQNEQLEKLQEQVTDLRSQNT--------KISTQLDFASKRYEMLQ 729 Query: 3036 ----AFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHA 3091 +R E+T+L + L Q+Q + L+ A+ + ++E++A + Sbjct: 730 DNVEGYRREITSLHERNQK-----LTATTQKQEQIINTMTQDLRGANEKLAVAEVRAENL 784 Query: 3092 QMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRA-TELQEQLSSEK 3150 + + L + S++ L E Q+ Q+ +L + + +R+ TE +++LSS+ Sbjct: 785 KKEKEMLKLSEVRLSQQRESLLAE---QRGQNLLLTNLQTIQGILERSETETKQRLSSQ- 840 Query: 3151 MVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTD---EVHL-LNDTLASEQ 3206 + +L+ E++ K +LE ++ +H + L+ L+ K + D +HL + L + Q Sbjct: 841 --IEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQ 898 Query: 3207 KKSRELQWALEKEKAKL--------GRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQ 3258 K+ L+ L + ++ G+ + +KE+++DL L +++ L L+ Sbjct: 899 KEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTS 958 Query: 3259 KQLLNESQQKIES--QRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHA 3316 + + Q + S + + + Q++EE +N+E++ L ES + + + ++ E+E Sbjct: 959 TSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVR-LKESAEFQTQLEKKLMEVEKEKQ- 1016 Query: 3317 QLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDR 3376 +LQ ++ +++QL E + + NE + ++LQ + Sbjct: 1017 ELQDD-----------KRRAIESMEQQLSELKKTLSSVQNEVQ----EALQRASTALSNE 1061 Query: 3377 QVHRKTLQTEQEANTEGQKKMH-ELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEF 3435 Q R+ Q + + E Q K EL D++ L+ ++QV K+ Q L+ Q+ Sbjct: 1062 QQARRDCQEQAKIAVEAQNKYERELMLHAADVEA-LQAAKEQVSKMASVRQHLEETTQKA 1120 Query: 3436 QKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIE-------GETKESNYA 3488 + Q LE + E R + ++ +N +L +IE KE Sbjct: 1121 ESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQG 1180 Query: 3489 KL-IEMNGGGTGCNHELEM---IRQKLQCVASKLQVLP------QKASERLQFETADDED 3538 L + ++ G LE+ IR++ + ++ +V ++ E L+ E + +D Sbjct: 1181 PLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQD 1240 Query: 3539 FIWVQENIDEIILQLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQNAE------------ 3586 + N + +Q+ T Q EE + + + T ++LR+ E Sbjct: 1241 SL----NAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAK 1296 Query: 3587 ----------LTGHISQLTEEKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRFSLNGGANI 3636 L ++L+E+ L+ LEE ++ ++ N S + Sbjct: 1297 VRKLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKAR-----NQHLVSQQKDPDT 1351 Query: 3637 EAI--IASEKEVWNREKLTLQKSLKRAEAEVYKLKAEL-RNDSLLQTLSPDSEHVTLKR 3692 E + SEKEV + L + + R +AE+ + A L N +L+Q+L D V ++ Sbjct: 1352 EEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEK 1410 >gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens] Length = 1979 Score = 179 bits (453), Expect = 6e-44 Identities = 350/1771 (19%), Positives = 727/1771 (41%), Gaps = 190/1771 (10%) Query: 6 RQKKLEAGKAKLAQFRQR----KAQSDGQSPSKKQKKKRKTSSSK------HDVSAHHDL 55 +QK++E K Q + K QS QS T+SS H SA HD Sbjct: 101 QQKEVEISHLKARQIALQDQLLKLQSAAQSVPSGAGVPATTASSSFAYGISHHPSAFHDD 160 Query: 56 NID-------QSQCNEMYINSSQRVESTVIPESTIMRTLHSGEITSHEQGFSVELESEIS 108 ++D Q + N + N R+ES V I +T + + +Q +L++ I Sbjct: 161 DMDFGDIISSQQEINRLS-NEVSRLESEVGHWRHIAQTSKAQGTDNSDQSEICKLQNIIK 219 Query: 109 TTADDCSSEVNGCSFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLEMMESELA-GK 167 + S E++ M + N +++ + + E+ D +E +E+ L G Sbjct: 220 ELKQNRSQEIDDHQHEMSVLQ--NAHQQKLTEISRRHREE-LSDYEERIEELENLLQQGG 276 Query: 168 QHEIEELNRELEEMRVTYGT------EGLQQLQEFEAAIKQRDGIITQLTANLQQARREK 221 IE ++ EM+ T E +++++ E IK + ++ + RRE+ Sbjct: 277 SGVIETDLSKIYEMQKTIQVLQIEKVESTKKMEQLEDKIKDINKKLSSAENDRDILRREQ 336 Query: 222 DETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAK--QQILTHQQQLEE 279 ++ E ++ E+ + L+++ +LQ S ++ T + L Q+ +++ QQ L + Sbjct: 337 EQLNVEKRQIMEECENLKLECSKLQPSAVKQSDTMTEKERILAQSASVEEVFRLQQALSD 396 Query: 280 QDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQ--------EKETII 331 ++ + +D ++ L+ K+++ +E++K + + KEE+Q E E I Sbjct: 397 AENEIMRLSSLNQDNSLAEDNLKLKMRIEVLEKEKSLLSQEKEELQMSLLKLNNEYEVIK 456 Query: 332 E----------ELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELT 381 EL+ + E K EL ++ + L+ E++E Q + K+M L Sbjct: 457 STATRDISLDSELHDLRLNLEAKEQELNQSISEKETLIAEIEELDRQNQEATKHMILIKD 516 Query: 382 NSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMY 441 +++ + I +L + + +KR H+ + DI + ++ + + KL Q L++++ Sbjct: 517 QLSKQQNEGDSIISKLKQDLNDEKKRVHQLEDDKMDITKELDVQKE-KLIQSEVALNDLH 575 Query: 442 GQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQI-KLMNVAINELNI 500 + Q ++ + + Q+ + + + + L +I NE+++ ++ N + LN Sbjct: 576 LTK--QKLEDKVENLVDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIRNELMQSLN- 632 Query: 501 KLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNE 560 QD+NS K+ L L+E+ A R L+ + EL E +++ + + KL Sbjct: 633 --QDSNSN---FKDTL---LKEREAEVRNLKQNLSELEQLNENLKKVAFDVKMENEKL-- 682 Query: 561 AHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKE----KNAVLDRMAE 616 + ED++ ++ +L L+ V K++ +E E K +L+ A Sbjct: 683 ----VLACEDVRHQLEECLAGNNQLSLEKNTIVETLKMEKGEIEAELCWAKKRLLEE-AN 737 Query: 617 SQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQ 676 E +E L S+ L+ LE EH I + + KD K+ I+ + + + Sbjct: 738 KYEKTIEEL------SNARNLNTSALQLEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKE 791 Query: 677 KIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEK 736 + + + + +Q QL I+K + + L K LQ EL K + LR+ E Sbjct: 792 TKDVLS----SSLEEQKQLTQLINKKEIFIEKL---KERSSKLQ-EELDKYSQALRKNEI 843 Query: 737 EKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKD--EKKTLEDMLKIH 794 + T+E++ + L MKE+ N LQE+ +L E S + KTL+ + ++ Sbjct: 844 LRQTIEEKDRSLG--------SMKEENNHLQEELERLREEQSRTAPVADPKTLDSVTELA 895 Query: 795 TPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAE 854 + VSQ L++IK ++ + K + +IE+ K Q +Q +E +K+ + F + Sbjct: 896 SEVSQ------LNTIKEHLEEEI--KHHQKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQH 947 Query: 855 KNFEVNYQEL----QEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTV 910 + + +L EE L K + ++ +++ + ++ + +E +Q +N Sbjct: 948 EQMNATHTQLFLEKDEEIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQETKVQSLNIENG 1007 Query: 911 KMKSSVFDED-----KTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQ 965 K + + K LE+ + EK+ + + +++K E +L+Q + + Sbjct: 1008 SEKHDLSKAETERLVKGIKERELEIKLLNEKNISLTKQIDQLSKDEVGKLTQIIQQKDLE 1067 Query: 966 LKQKHGEISFLN--EEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGV 1023 ++ H IS + ++V L+Q+ + ++ ++ ++N EN T+ ++D V Sbjct: 1068 IQALHARISSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTREN-SHLKTEYHKMMDIV 1126 Query: 1024 VTMTSR--GAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEE-------SKQEQLILDH 1074 + + K++ F + M + + + + E+ S++ Q +L Sbjct: 1127 AAKEAALIKLQDENKKLSTRFESSGQDMFRETIQNLSRIIREKDIEIDALSQKCQTLLAV 1186 Query: 1075 LPSVTKESSLRATQPSENDKLQKELNVLKSE--------QNDLRLQMEAQRICLSLVYST 1126 L + + + ++ ++L +E + LK + Q + Q L Sbjct: 1187 LQTSSTGNEAGGVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEEL 1246 Query: 1127 HVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHL 1186 H Q + ++++ + L LI + E+ +L+ Q Q + G L Sbjct: 1247 HQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQELAQVQHS--IGQLCNTKDL 1304 Query: 1187 LIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYR 1246 L+GKL + S L T S A K EV +E E + E LQ+ Sbjct: 1305 LLGKLDIISPQLSSASLLTPQSA---ECLRASKSEVLSESSELLQQELEELRK-SLQEKD 1360 Query: 1247 YEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGE-----ENLPKEE 1301 ++ QEN H L + + + L + +QTD + E + L KE+ Sbjct: 1361 ATIRTLQENNHRLSDSIAAT--------SELERKEHEQTDSEIKQLKEKQDVLQKLLKEK 1412 Query: 1302 TEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNY 1361 + S + + +K + L T L+E++ LE I L+ + ++ + Y Sbjct: 1413 DLLIKAKSDQLLSSNENFTNKVNENELLRQAVTNLKERILILEMDIGKLKGENEKIVETY 1472 Query: 1362 EAEIHCLQKRLQAVSESTVPPSLPV-DSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEF 1420 + + QA+ E+ + S+ + + S ++ + +K+ G +GE Sbjct: 1473 RGK----ETEYQALQETNMKFSMMLREKEFECHSMKEKALAFEQLLKEKEQGK---TGE- 1524 Query: 1421 GVKEETNIVKLLEKQ---YQEQLEEEVAKVIVSMSIAFAQQTELSRISGG--KENTASSK 1475 + + N VK ++++ +Q++ ++ + + A Q E+ R+ + N + Sbjct: 1525 -LNQLLNAVKSMQEKTVVFQQERDQVMLALKQKQMENTALQNEVQRLRDKEFRSNQELER 1583 Query: 1476 QAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDP 1535 + + + E Y E ++D+ + K +++ L ++L + SN+ Sbjct: 1584 LRNHLLESEDSYTREALAAEDR---------EAKLRKKVTVLEEKL------VSSSNAME 1628 Query: 1536 HDIPESKDCVLTISEEMF----SKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMR 1591 + ++ V ++ E++ +D+T + +++ ++ + M+ LE + Sbjct: 1629 NASHQASVQVESLQEQLNVVSKQRDETALQLSVSQEQVKQYALSLANLQMV----LEHFQ 1684 Query: 1592 QELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSE 1651 QE Y + + L + E LQE + N L S + + V E Sbjct: 1685 QEEKAMYSAELEKQKQLIAEWKKNAENLEGKVISLQECLDEANAALDSASRLTEQLDVKE 1744 Query: 1652 RERVLLEELEALKQLSLAGREKLCCELRNSS 1682 + L+ L+Q L +K L NSS Sbjct: 1745 EQIEELKRQNELRQEMLDDVQKKLMSLANSS 1775 Score = 173 bits (438), Expect = 3e-42 Identities = 356/1693 (21%), Positives = 699/1693 (41%), Gaps = 252/1693 (14%) Query: 1300 EETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEK--TKLEEQVQELESLISSLQQQLKET 1357 E TE + + ++I+ H S + L+K T LEE+ + E I + Sbjct: 40 EGTEEVEAELPDSRTKEIEAIHAILRSENERLKKLCTDLEEKHEASEIQIKQQSTSYRNQ 99 Query: 1358 EQNYEAEIHCLQKR----------LQAVSESTVPPSLPVDSVVITESDAQR-TMYPGSCV 1406 Q E EI L+ R LQ+ ++S VP V + + S A + +P + Sbjct: 100 LQQKEVEISHLKARQIALQDQLLKLQSAAQS-VPSGAGVPATTASSSFAYGISHHPSAFH 158 Query: 1407 KKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISG 1466 ++D S + + +N V LE + +A+ + + Q+E+ ++ Sbjct: 159 DDDMDFGDIISSQQEINRLSNEVSRLESEVGHW--RHIAQTSKAQGTDNSDQSEICKLQN 216 Query: 1467 G----KENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELG 1522 K+N + H ++ KL++ I + E + ++E + L L Sbjct: 217 IIKELKQNRSQEIDDHQHEMSVLQNAHQQKLTE--ISRRHREELS-DYEERIEELENLLQ 273 Query: 1523 EHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEIS-----VSSMDAS 1577 + G ++ +D I E + + + E K + + D+I +SS + Sbjct: 274 QGGSGVI--ETDLSKIYEMQKTIQVLQIEKVESTKKM---EQLEDKIKDINKKLSSAEND 328 Query: 1578 RQLMLNE-EQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQ-----EEIK 1631 R ++ E EQL +++++ + + + L+ + ++Q + E + L EE+ Sbjct: 329 RDILRREQEQLNVEKRQIMEECENLKLECSKLQPSAVKQSDTMTEKERILAQSASVEEVF 388 Query: 1632 RLNRQLAQR-------SSIDNENLVSERERVLLEELEAL-KQLSLAGREKLCCELRNSST 1683 RL + L+ SS++ +N ++E L +E L K+ SL +EK EL+ S Sbjct: 389 RLQQALSDAENEIMRLSSLNQDNSLAEDNLKLKMRIEVLEKEKSLLSQEKE--ELQMSLL 446 Query: 1684 QTQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTA 1743 + N E ++ ++ LD + D+ + + E+ Q + + + L+ ++ Sbjct: 447 KLNNEYE---VIKSTATRDISLDSELHDLRLNLEAKEQELNQSISEK--ETLIAEIEELD 501 Query: 1744 AVEETIGRHVLGILDRSSKSQSSA-SLIWRSEAEAS-VKSCVHE------EHTRVTDESI 1795 + +H++ I D+ SK Q+ S+I + + + + K VH+ + T+ D Sbjct: 502 RQNQEATKHMILIKDQLSKQQNEGDSIISKLKQDLNDEKKRVHQLEDDKMDITKELDVQK 561 Query: 1796 PSYSGSDMPRNDINMWSKVTEEGTE-LSQRLVRSGFAGTEIDPENEELMLNI---SSRLQ 1851 S++ ND+++ + E+ E L +L +S + I EN EL +I L Sbjct: 562 EKLIQSEVALNDLHLTKQKLEDKVENLVDQLNKSQESNVSIQKENLELKEHIRQNEEELS 621 Query: 1852 AAVEKLLEAISETSSQ--------------------LEHAKVTQTELMRESFRQKQEATE 1891 +L++++++ S+ L + L + +F K E + Sbjct: 622 RIRNELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLSELEQLNENLKKVAFDVKMENEK 681 Query: 1892 SLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQE 1951 + E++R +L E QL++E + T+ E EK +I E E Sbjct: 682 LVLACEDVRHQLEECLAGNNQLSLE-------------KNTIVETLKMEKGEI----EAE 724 Query: 1952 LLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQ 2011 L A RL E E + ++ E LS + + + L++ +K E E++ Sbjct: 725 LCWAKKRLLE---EANKYEKTIEELSNARNLNTSALQLEHEHLIKLNQKKDMEIAELKKN 781 Query: 2012 AEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDE 2071 E++ D ++ L +EEQ + +L +K + L++++ L+++L+K + L + Sbjct: 782 IEQMDTDHKETKDVLSSSLEEQ-KQLTQLINKKEIFIEKLKERSSKLQEELDKYSQALRK 840 Query: 2072 QAIDRE-------------HERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHL 2118 I R+ E + Q+E+++L ++ R P+++ +T + + Sbjct: 841 NEILRQTIEEKDRSLGSMKEENNHLQEELERLREEQS---RTAPVADPKTLD------SV 891 Query: 2119 KEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVEDRKHFGAVEAKPEL- 2177 E + S+L KE L+ +I+ + IE +L Q+L E +K + E Sbjct: 892 TELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQ-EQKKEMDEFRYQHEQM 950 Query: 2178 -SLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRL 2236 + QL E+D +EI +L++ +EQ + +L + +++Q + + + K + + Sbjct: 951 NATHTQLFLEKD------EEIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQETKVQSLNI 1004 Query: 2237 QELEQENKLFKDDMEKLGLAIKESD-----------AMSTQDQHVL---FGKFAQIIQEK 2282 + +++ L K + E+L IKE + +++ Q + GK QIIQ+K Sbjct: 1005 ENGSEKHDLSKAETERLVKGIKERELEIKLLNEKNISLTKQIDQLSKDEVGKLTQIIQQK 1064 Query: 2283 EVEIDQLN---------EQVTKLQQQLKITTDNK-----VIEEKNELIRDLETQIECLMS 2328 ++EI L+ + V LQQQL+ + V+ EK L+T+ +M Sbjct: 1065 DLEIQALHARISSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMMD 1124 Query: 2329 DQECVKRNREEEIEQLNEVIEKLQQELANIGQ----KTSMNAHSLSEEADSLKHQLDVVI 2384 + +E + +L + +KL + GQ +T N + E D L Sbjct: 1125 ----IVAAKEAALIKLQDENKKLSTRFESSGQDMFRETIQNLSRIIREKDIEIDALSQKC 1180 Query: 2385 AEKLALEQQVETAN----------EEMTFMKNVLKETNFKMNQLTQELFSL--KRERESV 2432 LA+ Q T N EE+ ++ LK+ KM + Q++ + + ES Sbjct: 1181 QTLLAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESA 1240 Query: 2433 EKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSF------EENGKGSI 2486 + + + + V +D S + +L+V T +N+T K+F ++ G + Sbjct: 1241 QLQEELHQLQAQVLVD--SDNNSKLQVDYTGLIQSYEQNETKLKNFGQELAQVQHSIGQL 1298 Query: 2487 INLETRLL--------QLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKI 2538 N + LL QL S+ S + +C + K E +E+LQ+++ L+K Sbjct: 1299 CNTKDLLLGKLDIISPQL-SSASLLTPQSAECLRASK--SEVLSESSELLQQELEELRKS 1355 Query: 2539 VEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQ----NLNQLRE--DELGSD 2592 ++EK A + +QE D+ +SE ER + + QL+E D L Sbjct: 1356 LQEKDAT-------IRTLQENNHRLSDSIAATSELERKEHEQTDSEIKQLKEKQDVLQKL 1408 Query: 2593 ISALTLRISELESQVV---EMHTSLILEKEQVEIAEKNVLEKEKKL-LELQKLLEGNEK- 2647 + L I Q++ E T+ + E E + A N+ E+ L +++ KL NEK Sbjct: 1409 LKEKDLLIKAKSDQLLSSNENFTNKVNENELLRQAVTNLKERILILEMDIGKLKGENEKI 1468 Query: 2648 ------KQRE---------------KEKKRSPQDVEVLKTTTELFHSNEESGFFNELEAL 2686 K+ E +EK+ ++ E +E G EL L Sbjct: 1469 VETYRGKETEYQALQETNMKFSMMLREKEFECHSMKEKALAFEQLLKEKEQGKTGELNQL 1528 Query: 2687 RAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKE- 2745 + + + ++++ +++ L K+ T+LQ ++ ++RD + ++L L Sbjct: 1529 LNAVKSMQEKTVVFQQERDQVMLALKQKQMENTALQNEVQRLRDKEFRSNQELERLRNHL 1588 Query: 2746 DETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECS 2805 E+E +++A E KL K + + +SSSN ++NA Q ++Q E Sbjct: 1589 LESEDSYTREALAAEDREAKLRKKVTVLEEKL--VSSSN-----AMENASHQASVQVESL 1641 Query: 2806 SEEVTEIISQFTE 2818 E++ + Q E Sbjct: 1642 QEQLNVVSKQRDE 1654 Score = 170 bits (430), Expect = 3e-41 Identities = 359/1736 (20%), Positives = 736/1736 (42%), Gaps = 261/1736 (15%) Query: 1832 GTEIDPENEELML-NISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEAT 1890 GT+ ++E L NI L+ + ++ S L++A Q +L S R ++E + Sbjct: 202 GTDNSDQSEICKLQNIIKELKQNRSQEIDDHQHEMSVLQNAH--QQKLTEISRRHREELS 259 Query: 1891 ESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQ 1950 + + EEL L + + +LSK Y +KT+ QI EK + ++EQ Sbjct: 260 DYEERIEELENLLQQGGSG--VIETDLSKI------YEMQKTIQVLQI-EKVESTKKMEQ 310 Query: 1951 ELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQC 2010 ++++++ + + +R++L R++E + E ++Q+++E E L E ++Q Sbjct: 311 ----LEDKIKDINKKLSSAENDRDILRREQEQLNVE----KRQIMEECENLKLECSKLQP 362 Query: 2011 QAEKVRDDLQKQVKALEIDVE-EQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFL 2069 A K D + ++ + L E+V R + + E+M L NQ + ++ + Sbjct: 363 SAVKQSDTMTEKERILAQSASVEEVFRLQQALSDAENEIMRLSSLNQDNSLAEDNLKLKM 422 Query: 2070 DEQAIDREHERDVFQQEIQKLEQQL-KVVPRFQPISEHQTREVEQLANHLKEKTDKCSEL 2128 + +++E + + QE ++L+ L K+ ++ I TR++ + E D L Sbjct: 423 RIEVLEKE--KSLLSQEKEELQMSLLKLNNEYEVIKSTATRDISLDS----ELHDLRLNL 476 Query: 2129 LLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVEDRKHFGAVEAKPELSLEVQLQAERD 2188 +++L + I E+ I ++E R+ ++A KH + K +LS + Q E D Sbjct: 477 EAKEQELNQSISEKETLIAEIEELDRQNQEAT-----KHM--ILIKDQLSKQ---QNEGD 526 Query: 2189 AIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKK---ESTTRLQELEQENKL 2245 +I I+ L++ L ++ + ++ + +L++QK+ +S L +L + Sbjct: 527 SI------ISKLKQDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDLHLTKQK 580 Query: 2246 FKDDMEKLGLAIKESDA--MSTQDQHVLFGKFAQIIQEKEVEIDQL-NEQVTKLQQQLKI 2302 +D +E L + +S +S Q +++ + + I++ E E+ ++ NE + L Q Sbjct: 581 LEDKVENLVDQLNKSQESNVSIQKENL---ELKEHIRQNEEELSRIRNELMQSLNQDSNS 637 Query: 2303 TTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKT 2362 + +++E+ +R+L+ + E+EQLNE ++K+ ++ Sbjct: 638 NFKDTLLKEREAEVRNLKQNLS---------------ELEQLNENLKKVAFDV------- 675 Query: 2363 SMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKET-NFKMNQLTQE 2421 M L + ++HQL+ +A N +++ KN + ET + ++ E Sbjct: 676 KMENEKLVLACEDVRHQLEECLA-----------GNNQLSLEKNTIVETLKMEKGEIEAE 724 Query: 2422 L-FSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEE 2480 L ++ KR E K + E N + S + E E ++ + K +E K+ E+ Sbjct: 725 LCWAKKRLLEEANKYEKTIEELSNARNLNTSALQLEHEHLIKLNQKKDMEIAELKKNIEQ 784 Query: 2481 NGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVE 2540 ++T + + +S+ E KQ+ + + + E L+++ LQ+ ++ Sbjct: 785 --------MDTDHKETKDVLSSSLEE----QKQLTQLINKKEIFIEKLKERSSKLQEELD 832 Query: 2541 EKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQN-LNQLREDELGSDISA--LT 2597 + A ++I + ++E +D S + E ++Q L +LRE++ + A T Sbjct: 833 KYSQALRKNEILRQTIEE-----KDRSLGSMKEENNHLQEELERLREEQSRTAPVADPKT 887 Query: 2598 L-RISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKR 2656 L ++EL S+V +++T +E+++ +K + ++ + ++L + L+ +K+ E + Sbjct: 888 LDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQH 947 Query: 2657 SPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKET 2716 + T T+LF +E E+++L+ K +L ++ + ++ +ET Sbjct: 948 EQMNA----THTQLFLEKDE-----EIKSLQKTIEQIKTQLHEERQDIQTDNSDIF-QET 997 Query: 2717 NMTSLQKDLSQVRDHLAEAK-EKL--SILEKEDETEVQESKKACMFEPLPIKLSKS---- 2769 + SL + + L++A+ E+L I E+E E ++ K + + + +LSK Sbjct: 998 KVQSLNIENGSEKHDLSKAETERLVKGIKERELEIKLLNEKNISLTKQID-QLSKDEVGK 1056 Query: 2770 ---IASQTDGTL-----KISSSNQTPQILVKNAGIQINLQSECSSEEVTEIISQFTEK-- 2819 I Q D + +ISS++ T ++ +Q E+V ++++ T + Sbjct: 1057 LTQIIQQKDLEIQALHARISSTSHTQDVVYLQQQLQAYAMER---EKVFAVLNEKTRENS 1113 Query: 2820 -----IEKMQELHAAEIL---------------------DMESRHISETETLKREHYVAV 2853 KM ++ AA+ DM I + RE + + Sbjct: 1114 HLKTEYHKMMDIVAAKEAALIKLQDENKKLSTRFESSGQDMFRETIQNLSRIIREKDIEI 1173 Query: 2854 QLLKEECGTLKAVIQCLRS-KEGSSIPELAHSDAYQTREICSSD--SGSDWGQGIYLTHS 2910 L ++C TL AV+Q + E + + Q R+ +W Q + T Sbjct: 1174 DALSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTT-- 1231 Query: 2911 QGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQV--LSLTESPYSDGEDHSIQQV 2968 + E ++ + + + L+ + +N +QV L +S Y E Sbjct: 1232 -----VQNMQHESAQLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQS-YEQNETKLKNFG 1285 Query: 2969 SEPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLE 3028 E L + + I + + KDL+ L + + S + E L A + L Sbjct: 1286 QE--LAQVQHSIGQLCNTKDLL----LGKLDIISPQLSSASLLTPQSAECLRASKSEVLS 1339 Query: 3029 ERSVLLAAFRTELT-ALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQ 3087 E S LL EL +L DA + L++ A E L++ + SEI+ Sbjct: 1340 ESSELLQQELEELRKSLQEKDAT--IRTLQENNHRLSDSIAATSE-LERKEHEQTDSEIK 1396 Query: 3088 ALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLS 3147 L + + + LK + K + L + + +++ E ++ ++ T L+E++ Sbjct: 1397 QLKEKQDVLQKLLKEKDLLIKAKSDQLLSSNENFTNKVNENEL----LRQAVTNLKERIL 1452 Query: 3148 SEKMVVAELKSE---LAQTKLELETTLKA-QHKHLKELEAFRLEVKDKTDEVHLLND-TL 3202 +M + +LK E + +T ET +A Q ++K F + +++K E H + + L Sbjct: 1453 ILEMDIGKLKGENEKIVETYRGKETEYQALQETNMK----FSMMLREKEFECHSMKEKAL 1508 Query: 3203 ASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLN------LLLE 3256 A EQ EKE+ K G EL L +++S +++ + +L Sbjct: 1509 AFEQLLK-------EKEQGKTG--------ELNQLLNAVKSMQEKTVVFQQERDQVMLAL 1553 Query: 3257 QQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHA 3316 +QKQ+ N + Q E QR L D + Q LLESE RE + DRE +L Sbjct: 1554 KQKQMENTALQN-EVQR-LRDKEFRSNQELERLRNHLLESEDSYTREALAAEDREAKLRK 1611 Query: 3317 Q-------LQSSDGTGQSRPPLPS------EDLLKELQKQLEEKHSRIVELLNETEKYKL 3363 + L SS ++ S ++ L + KQ +E ++ + ++Y L Sbjct: 1612 KVTVLEEKLVSSSNAMENASHQASVQVESLQEQLNVVSKQRDETALQLSVSQEQVKQYAL 1671 Query: 3364 DSLQTRQQME----KDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQR---------- 3409 + +E +++ ++ L+ +++ E +K L+ KV LQ Sbjct: 1672 SLANLQMVLEHFQQEEKAMYSAELEKQKQLIAEWKKNAENLEGKVISLQECLDEANAALD 1731 Query: 3410 -------QLEEKRQQVYKLDLEGQRLQGIMQEFQKQELEREEKRESR--RILYQNL 3456 QL+ K +Q+ +L + + Q ++ + QK+ + E + ++L +NL Sbjct: 1732 SASRLTEQLDVKEEQIEELKRQNELRQEMLDDVQKKLMSLANSSEGKVDKVLMRNL 1787 Score = 160 bits (404), Expect = 3e-38 Identities = 324/1653 (19%), Positives = 669/1653 (40%), Gaps = 270/1653 (16%) Query: 1245 YRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEF 1304 +R E+ D++E + L N + + + V++T LSKI+ Q L+ + K+ Sbjct: 254 HREELSDYEERIEELENLLQQGGSG--VIETDLSKIYEMQKTIQVLQIEKVESTKK---- 307 Query: 1305 LSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAE 1364 M LED + KLSS ++ EQ Q ++ ++Q+ E +N + E Sbjct: 308 ------MEQLEDKIKDINKKLSSAENDRDILRREQEQ-----LNVEKRQIMEECENLKLE 356 Query: 1365 IHCLQKRLQAVSES-TVPPSLPVDSVVITE--------SDAQRTMYPGSCVKKN---IDG 1412 LQ S++ T + S + E SDA+ + S + ++ + Sbjct: 357 CSKLQPSAVKQSDTMTEKERILAQSASVEEVFRLQQALSDAENEIMRLSSLNQDNSLAED 416 Query: 1413 TIEFSGEFGVKEETNIVKLLEKQYQEQL---------EEEVAKVIVSMSIAF-------- 1455 ++ V E+ K L Q +E+L E EV K + I+ Sbjct: 417 NLKLKMRIEVLEKE---KSLLSQEKEELQMSLLKLNNEYEVIKSTATRDISLDSELHDLR 473 Query: 1456 ----AQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFK 1511 A++ EL++ KE + + + +Q Q M L +DQ+ Q E + K Sbjct: 474 LNLEAKEQELNQSISEKETLIA--EIEELDRQNQEATKHMILIKDQLSKQQNEGDSIISK 531 Query: 1512 EEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISV 1571 L ++L + K + D DI + D + E + Sbjct: 532 -----LKQDLNDEKKRVHQLEDDKMDITKELD---------------------VQKEKLI 565 Query: 1572 SSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIK 1631 S A L L +++LED + LV Q + Q++ +++ ++ E R+++E+L Sbjct: 566 QSEVALNDLHLTKQKLEDKVENLVDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIRN 625 Query: 1632 RLNRQLAQRSSID-NENLVSERE---RVLLEELEALKQLS----------LAGREKL--- 1674 L + L Q S+ + + L+ ERE R L + L L+QL+ EKL Sbjct: 626 ELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLSELEQLNENLKKVAFDVKMENEKLVLA 685 Query: 1675 CCELRNSSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKI 1734 C ++R+ + GN NQ +E+ T E L + ++ E+ ++ L++AN Sbjct: 686 CEDVRHQLEECLAGN-NQLSLEKNTIVET-LKMEKGEIEAELCWAKKRLLEEAN------ 737 Query: 1735 LLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDES 1794 K +EE L S HE ++ + Sbjct: 738 -----KYEKTIEELSNARNLN---------------------TSALQLEHEHLIKLNQKK 771 Query: 1795 IPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAV 1854 +++ +N M + E LS L E ++ + + ++ + + Sbjct: 772 --DMEIAELKKNIEQMDTDHKETKDVLSSSL------------EEQKQLTQLINKKEIFI 817 Query: 1855 EKLLEAISETSSQLEHAK--VTQTELMRESFRQKQEATESLK-----CQEELRERLHEES 1907 EKL E S+ +L+ + + E++R++ +K + S+K QEEL E+S Sbjct: 818 EKLKERSSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEELERLREEQS 877 Query: 1908 RARE-----------QLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCAS 1956 R +LA E+S+ + K E +I+ II+ Q + Sbjct: 878 RTAPVADPKTLDSVTELASEVSQLNTI-------KEHLEEEIKHHQKIIEDQNQSKMQLL 930 Query: 1957 NRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVR 2016 LQE + E + + + E ++ + E + L + E++ + E + + Sbjct: 931 QSLQEQKKEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKTIEQIKTQLHEERQDIQTDN 990 Query: 2017 DDLQKQVKALEIDVEE----------QVSRFIELEQEKNTELMDLRQQNQALEKQLEKM- 2065 D+ ++ K +++E + R ++ +E+ E+ L ++N +L KQ++++ Sbjct: 991 SDIFQETKVQSLNIENGSEKHDLSKAETERLVKGIKERELEIKLLNEKNISLTKQIDQLS 1050 Query: 2066 ------------RKFLDEQAIDREHERDVFQQEIQKLEQQLKVVP----RFQPISEHQTR 2109 +K L+ QA+ Q++ L+QQL+ + + +TR Sbjct: 1051 KDEVGKLTQIIQQKDLEIQALHARISSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTR 1110 Query: 2110 EVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVEDRKHFG 2169 E +HLK + K +++ +KE +Q+ N+ KL R Q + E ++ Sbjct: 1111 E----NSHLKTEYHKMMDIVAAKEAALIKLQDENK---KLSTRFESSGQDMFRETIQNLS 1163 Query: 2170 AVEAKPELSLEVQLQAERDAIDRKEKEITNLEE---QLEQFREELENKNEEVQQLHMQLE 2226 + + ++ ++ Q + + + T E QF E L+ +++ QQ+ ++E Sbjct: 1164 RIIREKDIEIDALSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQQVK-KME 1222 Query: 2227 IQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEI 2286 K++ T +Q ++ E+ ++++ +L + D+ + V + Q ++ E ++ Sbjct: 1223 EWKQQVMTTVQNMQHESAQLQEELHQLQAQVLV-DSDNNSKLQVDYTGLIQSYEQNETKL 1281 Query: 2287 DQLNEQVTKLQQQL-KITTDNKVIEEKNELIRDLETQIECLMSDQ-ECVKRNREEEIEQL 2344 +++ ++Q + ++ ++ K ++I + L EC++ ++ E + + Sbjct: 1282 KNFGQELAQVQHSIGQLCNTKDLLLGKLDIISPQLSSASLLTPQSAECLRASKSEVLSES 1341 Query: 2345 NEVIEKLQQELANIGQKTSMNAHSLSEE----ADSLKHQLDVVIAEKLALEQQVETANEE 2400 +E++++ +EL Q+ +L E +DS+ ++ E + +++ E+ Sbjct: 1342 SELLQQELEELRKSLQEKDATIRTLQENNHRLSDSIAATSELERKEHEQTDSEIKQLKEK 1401 Query: 2401 MTFMKNVLKETNFKMNQLTQELFSLKR-------ERESVEK-IQSIPENSVNVAIDHLSK 2452 ++ +LKE + + + +L S E E + + + ++ E + + +D + K Sbjct: 1402 QDVLQKLLKEKDLLIKAKSDQLLSSNENFTNKVNENELLRQAVTNLKERILILEMD-IGK 1460 Query: 2453 DKPELEVVLTEDALKSLENQTYFKSFEENGKGSII---------NLETRLLQLESTVSAK 2503 K E E ++ K E Q E N K S++ +++ + L E + K Sbjct: 1461 LKGENEKIVETYRGKETEYQALQ---ETNMKFSMMLREKEFECHSMKEKALAFEQLLKEK 1517 Query: 2504 DL----ELTQCYKQIKDMQEQ--------GQFETEMLQKKIVN--LQKIVEEKVAAALVS 2549 + EL Q +K MQE+ Q + QK++ N LQ V+ S Sbjct: 1518 EQGKTGELNQLLNAVKSMQEKTVVFQQERDQVMLALKQKQMENTALQNEVQRLRDKEFRS 1577 Query: 2550 QIQLEAVQEYAKFCQDNQT---ISSEPERTNIQNLNQLREDELGSDISALTLRISELESQ 2606 +LE ++ + +D+ T +++E ++ + E++L S +A+ + Q Sbjct: 1578 NQELERLRNHLLESEDSYTREALAAEDREAKLRKKVTVLEEKLVSSSNAMENASHQASVQ 1637 Query: 2607 VVEMHTSL-ILEKE------QVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQ 2659 V + L ++ K+ Q+ ++++ V + L LQ +LE + ++EK Sbjct: 1638 VESLQEQLNVVSKQRDETALQLSVSQEQVKQYALSLANLQMVLEHFQ----QEEKAMYSA 1693 Query: 2660 DVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMT 2719 ++E K + N E+ E + + + +A A + A +L E+L VKE + Sbjct: 1694 ELEKQKQLIAEWKKNAEN---LEGKVISLQECLDEANAAL--DSASRLTEQLDVKEEQIE 1748 Query: 2720 SLQKDLSQVRDHLAEAKEKLSILEKEDETEVQE 2752 L++ ++ L + ++KL L E +V + Sbjct: 1749 ELKRQNELRQEMLDDVQKKLMSLANSSEGKVDK 1781 Score = 157 bits (397), Expect = 2e-37 Identities = 365/1866 (19%), Positives = 774/1866 (41%), Gaps = 302/1866 (16%) Query: 701 KLKDLQQSLVNSKSEEMTLQINELQ-KEIE----ILRQEEKEKGTLEQEVQELQLKTELL 755 ++ + + ++ +EE+ ++ + + KEIE ILR E + L++ +L+ K E Sbjct: 29 QISNFTKDMLMEGTEEVEAELPDSRTKEIEAIHAILRSENER---LKKLCTDLEEKHEAS 85 Query: 756 EKQMKEKENDLQEKFAQLEAENSILKDEKKTLED-MLKIHTPVSQEERLIFLDSIKSKSK 814 E Q+K++ + + Q E E S LK + L+D +LK+ + + + + S Sbjct: 86 EIQIKQQSTSYRNQLQQKEVEISHLKARQIALQDQLLKLQSAAQSVPSGAGVPATTASSS 145 Query: 815 --------------DSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVN 860 D + +I +E L + +L E+ R+ ++ N Sbjct: 146 FAYGISHHPSAFHDDDMDFGDIISSQQEINRLSNEVSRLESEVGHWRHIAQTSKAQGTDN 205 Query: 861 YQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDED 920 Q E L + +L+ +++++ +++ ++ L + H Q++ + + + + D + Sbjct: 206 SD--QSEICKLQNIIKELKQNRSQEIDDHQHEMSVL-QNAHQQKLTEISRRHREELSDYE 262 Query: 921 KTF--VAETLEMGE--VVEKDTTEL-----------MEKLEVTKREKLELSQRLSDLSEQ 965 + + L+ G V+E D +++ +EK+E TK+ + +L ++ D++++ Sbjct: 263 ERIEELENLLQQGGSGVIETDLSKIYEMQKTIQVLQIEKVESTKKME-QLEDKIKDINKK 321 Query: 966 LKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVT 1025 L + L E + L EK Q+ C L++ + + V+ DT + ++ Sbjct: 322 LSSAENDRDILRREQEQLNVEKRQIMEECENLKLECSKLQPSAVKQSDTMTEK--ERILA 379 Query: 1026 MTSRGAEGSVSKVNKSFGE-ESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSL 1084 ++ E V ++ ++ + E++IM ++ +N + K + I + KE SL Sbjct: 380 QSASVEE--VFRLQQALSDAENEIMRLSSLNQDNSLAEDNLKLKMRI----EVLEKEKSL 433 Query: 1085 RATQPSEND----KLQKELNVLKS----------EQNDLRLQMEAQRICLSLVYSTHVDQ 1130 + + E KL E V+KS E +DLRL +EA+ L+ S Sbjct: 434 LSQEKEELQMSLLKLNNEYEVIKSTATRDISLDSELHDLRLNLEAKEQELNQSISEKETL 493 Query: 1131 VREYME-----NEKDKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLH 1185 + E E E K + +K++L Q E + K+ Q + DE K +H Sbjct: 494 IAEIEELDRQNQEATKHMILIKDQLSKQQNEGDSIISKLKQ---------DLNDEKKRVH 544 Query: 1186 LLIGK---LQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDK-ENSGDYISENEDPE 1241 L + K + + +Q+ ++ + T + EDK EN D ++++++ Sbjct: 545 QLEDDKMDITKELDVQKEKLIQSEVALNDLHLT-----KQKLEDKVENLVDQLNKSQESN 599 Query: 1242 LQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEE 1301 + + EN+ L + + +L ++ L + Q ++ F + L + E Sbjct: 600 VSIQK-------ENLE-LKEHIRQNEEELSRIRNELMQSLNQDSNS---NFKDTLLKERE 648 Query: 1302 TEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKL----EEQVQELESLIS--------- 1348 E ++ ++ LE ++ N K K++ +E KL E+ +LE ++ Sbjct: 649 AEVRNLKQNLSELEQLNENLK-KVAFDVKMENEKLVLACEDVRHQLEECLAGNNQLSLEK 707 Query: 1349 -SLQQQLKETEQNYEAEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVK 1407 ++ + LK + EAE+ +KRL + I E R + + Sbjct: 708 NTIVETLKMEKGEIEAELCWAKKRLLEEANKY--------EKTIEELSNARNLNTSALQL 759 Query: 1408 KNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGG 1467 ++ E + K++ I +L + Q + + K ++S S+ +Q +L+++ Sbjct: 760 EH-----EHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDVLSSSLE--EQKQLTQLINK 812 Query: 1468 KENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKF---KEEFKPLSKELGEH 1524 KE + + QE+ L +++I QT E D KEE L +EL Sbjct: 813 KEIFIEKLKERSSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEELERL 872 Query: 1525 GKEILLSNSDPHDIPESKDCVLTISEEMFSKD--KTFIVRQSIHDEISVSSMDASRQLML 1582 +E S + P P++ D V ++ E+ + K + + H + + + S+ +L Sbjct: 873 REE--QSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLL 930 Query: 1583 NEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSS 1642 + L++ ++E+ +H+Q + H + + E+ + LQ+ I+++ QL + Sbjct: 931 --QSLQEQKKEMDEFRYQHEQ----MNATHTQLFLEKDEEIKSLQKTIEQIKTQLHE--- 981 Query: 1643 IDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQT--- 1699 ER+ + + + + E + S +NG+E + +T Sbjct: 982 --------ERQDIQTDNSDIFQ------------ETKVQSLNIENGSEKHDLSKAETERL 1021 Query: 1700 ---FKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGI 1756 KE+EL+ K +L+ + +L K ++L K EV K T +++ + + Sbjct: 1022 VKGIKERELEIK-------LLNEKNISLTKQIDQLSKD--EVGKLTQIIQQK-DLEIQAL 1071 Query: 1757 LDRSSKSQSSASLIWRSEA------EASVKSCVHEEHTRVTDESIPSYSGS-DMPRNDIN 1809 R S + + +++ + E V E TR Y D+ Sbjct: 1072 HARISSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMMDIVAAKEA 1131 Query: 1810 MWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKL------LEAISE 1863 K+ +E +LS R SG ++ E + + I ++ L L A+ + Sbjct: 1132 ALIKLQDENKKLSTRFESSG---QDMFRETIQNLSRIIREKDIEIDALSQKCQTLLAVLQ 1188 Query: 1864 TSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERL--------HEESRAREQL-- 1913 TSS A + E +++ + + +K EE ++++ HE ++ +E+L Sbjct: 1189 TSSTGNEAGGVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEELHQ 1248 Query: 1914 --------AVELSKAE----GVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQE 1961 + SK + G+I Y +T + QE + + Q L + Sbjct: 1249 LQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQELAQVQHSIGQLCNTKDLLLGK 1308 Query: 1962 LEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQK 2021 L+ Q+ L + E ++A + ++L E+ +L++++LE ++ + +D + Sbjct: 1309 LDIISPQLSSASLLTPQSAECLRAS----KSEVLSESSELLQQELEELRKSLQEKDATIR 1364 Query: 2022 QVKALEIDVEEQVSRFIELEQEKN----TELMDLRQQNQALEKQLEKMRKFL-------- 2069 ++ + + ++ ELE++++ +E+ L+++ L+K L++ + Sbjct: 1365 TLQENNHRLSDSIAATSELERKEHEQTDSEIKQLKEKQDVLQKLLKEKDLLIKAKSDQLL 1424 Query: 2070 --DEQAIDREHERDVFQQEIQKLEQQLKVVP---------RFQPISEHQTREVEQLANHL 2118 +E ++ +E ++ +Q + L++++ ++ + + ++ +E E A L Sbjct: 1425 SSNENFTNKVNENELLRQAVTNLKERILILEMDIGKLKGENEKIVETYRGKETEYQA--L 1482 Query: 2119 KEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVEDRKHFGAVEAKPELS 2178 +E K S +L KE ++E+ E+L ++E EQ E + AV++ E + Sbjct: 1483 QETNMKFSMMLREKEFECHSMKEKALAFEQL---LKEKEQGKTGELNQLLNAVKSMQEKT 1539 Query: 2179 LEVQLQAERD----AIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTT 2234 V Q ERD A+ +K+ E T L+ ++++ R++ N+E+++L L ++ ++S T Sbjct: 1540 --VVFQQERDQVMLALKQKQMENTALQNEVQRLRDKEFRSNQELERLRNHL-LESEDSYT 1596 Query: 2235 R--LQELEQENKLFKDDMEKLGLAIKESDAM------------STQDQHVLFGK----FA 2276 R L ++E KL K + S+AM S Q+Q + K A Sbjct: 1597 REALAAEDREAKLRKKVTVLEEKLVSSSNAMENASHQASVQVESLQEQLNVVSKQRDETA 1656 Query: 2277 QIIQEKEVEIDQLNEQVTKLQ------QQLKITTDNKVIEEKNELIRDLETQIECL---- 2326 + + ++ Q + LQ QQ + + +E++ +LI + + E L Sbjct: 1657 LQLSVSQEQVKQYALSLANLQMVLEHFQQEEKAMYSAELEKQKQLIAEWKKNAENLEGKV 1716 Query: 2327 MSDQECVKRN----------------REEEIEQLNEVIEKLQQELANIGQKTSMNAHSLS 2370 +S QEC+ +EE+IE+L E Q+ L ++ +K A+S Sbjct: 1717 ISLQECLDEANAALDSASRLTEQLDVKEEQIEELKRQNELRQEMLDDVQKKLMSLANSSE 1776 Query: 2371 EEADSL 2376 + D + Sbjct: 1777 GKVDKV 1782 Score = 157 bits (396), Expect = 3e-37 Identities = 387/1899 (20%), Positives = 764/1899 (40%), Gaps = 303/1899 (15%) Query: 601 EMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLG 660 +ML + V + +S+ E+E + +L S E L KL DLE +H + Sbjct: 36 DMLMEGTEEVEAELPDSRTKEIEAIHA-ILRSENERLKKLCTDLEEKHEAS--------E 86 Query: 661 IHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTL- 719 I KQQ +N++ QK + K I Q+QL+ KL+ QS+ + T Sbjct: 87 IQIKQQSTSYRNQLQQKEVEISHLKARQIALQDQLL----KLQSAAQSVPSGAGVPATTA 142 Query: 720 ------------------------------QINELQKEIEILRQE----------EKEKG 739 +IN L E+ L E K +G Sbjct: 143 SSSFAYGISHHPSAFHDDDMDFGDIISSQQEINRLSNEVSRLESEVGHWRHIAQTSKAQG 202 Query: 740 TLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKD-EKKTLEDMLKIHTP-- 796 T + E+ L+ +KE + + ++ + E S+L++ ++ L ++ + H Sbjct: 203 TDNSDQSEIC----KLQNIIKELKQNRSQEIDDHQHEMSVLQNAHQQKLTEISRRHREEL 258 Query: 797 VSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKN 856 EER+ L+++ + V E ++ + E + + Q +Q+ E++E + +K Sbjct: 259 SDYEERIEELENLLQQGGSGVIETDLSKIYEMQKTI--QVLQI-EKVESTKKMEQLEDKI 315 Query: 857 FEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNE----ELHLQRINPTTVKM 912 ++N + L ++D + + +QE K + + E +L ++ P+ VK Sbjct: 316 KDINKK--------LSSAENDRDILRREQEQLNVEKRQIMEECENLKLECSKLQPSAVK- 366 Query: 913 KSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGE 972 +S E + +A++ + EV + E+ + L L++ + +LK + Sbjct: 367 QSDTMTEKERILAQSASVEEVFRLQQALSDAENEIMRLSSLNQDNSLAEDNLKLKMR--- 423 Query: 973 ISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAE 1032 I L +E L QEKE++ + +L +N E ++S T+ S LD + E Sbjct: 424 IEVLEKEKSLLSQEKEELQMSLLKL-----NNEYEVIKSTATRDIS-LDSELHDLRLNLE 477 Query: 1033 GSVSKVNKSFGEESKIMVE-DKVSFENMTVGEESKQEQLILDHLPSVTKE--SSLRATQP 1089 ++N+S E+ ++ E +++ +N E +K LI D L E S + + Sbjct: 478 AKEQELNQSISEKETLIAEIEELDRQNQ---EATKHMILIKDQLSKQQNEGDSIISKLKQ 534 Query: 1090 SENDKLQKELNVLKSEQNDL--RLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLK 1147 ND+ +K ++ L+ ++ D+ L ++ +++ S V + ++ +E++ + +L Sbjct: 535 DLNDE-KKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDLHLTKQKLEDKVE----NLV 589 Query: 1148 EELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTLC 1207 ++L +QE + +QK LEL+ Q + + + L+ L + + S F TL Sbjct: 590 DQLNKSQESNV-SIQK-ENLELKEHIRQNEEELSRIRNELMQSLNQ---DSNSNFKDTL- 643 Query: 1208 SVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEY 1267 L E + N + E ++EN L+ ++V+ E + V + Sbjct: 644 --LKEREAEVRNLKQNLSELEQ----LNEN----LKKVAFDVKMENEKLVLACEDVRHQL 693 Query: 1268 NKLLVLQTRLSKIWGQQTDGMKLEFGE---------ENLPKEETEFLSIHSQMTNLEDID 1318 + L +LS + +K+E GE + L +E ++ +++N +++ Sbjct: 694 EECLAGNNQLSLEKNTIVETLKMEKGEIEAELCWAKKRLLEEANKYEKTIEELSNARNLN 753 Query: 1319 VN-------HKSKLSSLQDLEKTKLEEQVQELES--------LISSL--QQQLKETEQNY 1361 + H KL+ +D+E +L++ ++++++ L SSL Q+QL + Sbjct: 754 TSALQLEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQLINKK 813 Query: 1362 EAEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFG 1421 E I L++R + E + + +++ I+ G Sbjct: 814 EIFIEKLKERSSKLQEEL--------------DKYSQALRKNEILRQTIEEKDRSLG--S 857 Query: 1422 VKEETN-IVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAV 1480 +KEE N + + LE+ +EQ ++ +E+S+++ KE+ + H Sbjct: 858 MKEENNHLQEELERLREEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQK 917 Query: 1481 CQQEQHY--------FNEMKLSQDQIGFQ------TFETVDVKFKEEFKPLSK------- 1519 ++Q+ E K D+ +Q T + ++ EE K L K Sbjct: 918 IIEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKTIEQIKT 977 Query: 1520 ELGEHGKEILLSNSDPHDIPESKDCVLTI----SEEMFSKDKTFIVRQSIHDEISVSSMD 1575 +L E ++I NSD E+K L I + SK +T + + I + + Sbjct: 978 QLHEERQDIQTDNSD--IFQETKVQSLNIENGSEKHDLSKAETERLVKGIKERELEIKLL 1035 Query: 1576 ASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQRED-----QEQLQEEI 1630 + + L ++ + + E+ + Q QQ ++ H R Q+QLQ Sbjct: 1036 NEKNISLTKQIDQLSKDEVGKLTQIIQQKDLEIQALHARISSTSHTQDVVYLQQQLQAYA 1095 Query: 1631 KRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNE 1690 + A + EN + E + ++ A K+ +L KL E + ST+ ++ + Sbjct: 1096 MEREKVFAVLNEKTRENSHLKTEYHKMMDIVAAKEAALI---KLQDENKKLSTRFESSGQ 1152 Query: 1691 NQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIG 1750 ++ +T + + +D+ + LS + + LL V++T++ E G Sbjct: 1153 ---DMFRETIQNLSRIIREKDIEIDALSQK-----------CQTLLAVLQTSSTGNEAGG 1198 Query: 1751 ------RHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMP 1804 +L D+ K Q W+ + +V++ HE + E + + Sbjct: 1199 VNSNQFEELLQERDK-LKQQVKKMEEWKQQVMTTVQNMQHE--SAQLQEELHQLQAQVLV 1255 Query: 1805 RNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISET 1864 +D N SK+ + T L Q +NE + N L + + + Sbjct: 1256 DSDNN--SKLQVDYTGLIQSY-----------EQNETKLKNFGQELAQVQHSIGQLCNTK 1302 Query: 1865 SSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVI 1924 L + +L S Q A E L+ + E L E S +Q EL K+ Sbjct: 1303 DLLLGKLDIISPQLSSASLLTPQSA-ECLRASKS--EVLSESSELLQQELEELRKS---- 1355 Query: 1925 DGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQ-----QQIQEERELLSRQ 1979 EK R +QE + + + A++ L+ E EQ +Q++E++++L + Sbjct: 1356 ---LQEKDATIRTLQENNHRL----SDSIAATSELERKEHEQTDSEIKQLKEKQDVLQKL 1408 Query: 1980 KEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDV---EEQVSR 2036 + QLL E + E + + V +L++++ LE+D+ + + + Sbjct: 1409 LKEKDLLIKAKSDQLLSSNENFTNKVNENELLRQAV-TNLKERILILEMDIGKLKGENEK 1467 Query: 2037 FIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKV 2096 +E + K TE L++ N L ++E E +++ EQ LK Sbjct: 1468 IVETYRGKETEYQALQETNMKFSMMLR-----------EKEFECHSMKEKALAFEQLLK- 1515 Query: 2097 VPRFQPISEHQTREVEQLANHLKEKTDKC-------SELLLSKEQLQRDIQERNEEIEKL 2149 + +T E+ QL N +K +K +++L+ +Q Q + E+++L Sbjct: 1516 -----EKEQGKTGELNQLLNAVKSMQEKTVVFQQERDQVMLALKQKQMENTALQNEVQRL 1570 Query: 2150 ---EFRV-RELEQALLVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLE 2205 EFR +ELE+ R H +E++ + E +R+A + K++T LEE+L Sbjct: 1571 RDKEFRSNQELERL-----RNHL--LESEDSYTREALAAEDREA--KLRKKVTVLEEKLV 1621 Query: 2206 QFREELENKNE----EVQQLHMQLEI---QKKESTTRLQELEQENKLFKDDMEKLGLAIK 2258 +EN + +V+ L QL + Q+ E+ +L +++ K + + L + ++ Sbjct: 1622 SSSNAMENASHQASVQVESLQEQLNVVSKQRDETALQLSVSQEQVKQYALSLANLQMVLE 1681 Query: 2259 ESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRD 2318 K Q+I E + + L +V LQ+ L N ++ + L Sbjct: 1682 HFQQEEKAMYSAELEKQKQLIAEWKKNAENLEGKVISLQECL--DEANAALDSASRLTEQ 1739 Query: 2319 LETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELAN 2357 L+ + E + E +KR E E L++V +KL LAN Sbjct: 1740 LDVKEEQI----EELKRQNELRQEMLDDVQKKL-MSLAN 1773 Score = 142 bits (359), Expect = 5e-33 Identities = 336/1805 (18%), Positives = 725/1805 (40%), Gaps = 261/1805 (14%) Query: 374 KNMKLELTNSKQKE--------RQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQE 425 + ++ EL +S+ KE R +E +K+L +EE H+ S+ + +++ Sbjct: 43 EEVEAELPDSRTKEIEAIHAILRSENERLKKLCTDLEE----KHEASEIQ---IKQQSTS 95 Query: 426 TQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMK----------------TRHKG 469 + +L+Q E+ + +QI Q L Q AQ + H Sbjct: 96 YRNQLQQKEVEISHLKARQIALQDQLLKLQSAAQSVPSGAGVPATTASSSFAYGISHHPS 155 Query: 470 EMENALRSYSNITVNEDQIKLMNVAINELNI------------KLQDT-NSQKEKLKEEL 516 + + +I ++ +I ++ ++ L K Q T NS + ++ + Sbjct: 156 AFHDDDMDFGDIISSQQEINRLSNEVSRLESEVGHWRHIAQTSKAQGTDNSDQSEICKLQ 215 Query: 517 GLILEEKCALQRQLEDLVEELSFSREQIQ--------RARQTIAEQESKLNEAHKSLSTV 568 +I E K ++++D E+S + Q R R+ +++ E ++ E L Sbjct: 216 NIIKELKQNRSQEIDDHQHEMSVLQNAHQQKLTEISRRHREELSDYEERIEELENLLQQG 275 Query: 569 ED--LKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQ-EAELERL 625 ++ ++ E +K +++ +V + K K+E LE + + +++ ++ + ++ R Sbjct: 276 GSGVIETDLSKIYEMQKTIQVLQIEKVESTK-KMEQLEDKIKDINKKLSSAENDRDILRR 334 Query: 626 RTQLLFSHEEELSKLKEDLEIE-HRINIEKLKDNLGIHYKQQI--------------DGL 670 + L + ++ + E+L++E ++ +K + + K++I L Sbjct: 335 EQEQLNVEKRQIMEECENLKLECSKLQPSAVKQSDTMTEKERILAQSASVEEVFRLQQAL 394 Query: 671 QNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEI 730 + ++ + +DN + + N + ++ + ++SL++ + EE+ + + +L E E+ Sbjct: 395 SDAENEIMRLSSLNQDNSLAEDNLKLKMRIEVLEKEKSLLSQEKEELQMSLLKLNNEYEV 454 Query: 731 LRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDM 790 ++ +L+ E+ +L+L E E+++ + ++ + A++E + + ++ + M Sbjct: 455 IKSTATRDISLDSELHDLRLNLEAKEQELNQSISEKETLIAEIE---ELDRQNQEATKHM 511 Query: 791 LKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTF 850 + I +S+++ DSI SK K + +++ + L+ + + +E++ Q+ Sbjct: 512 ILIKDQLSKQQN--EGDSIISKLKQDLNDEKKRV-----HQLEDDKMDITKELDVQKEKL 564 Query: 851 SFAE---KNFEVNYQELQEEYACLLKVKDDLEDSK---NKQELEYKSKLKALNEELH--- 901 +E + + Q+L+++ L+ + ++S K+ LE K ++ EEL Sbjct: 565 IQSEVALNDLHLTKQKLEDKVENLVDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIR 624 Query: 902 ---LQRIN--------PTTVKMKSSVFDEDKTFVAETLEMGEVVEK---DTTELMEKLEV 947 +Q +N T +K + + K ++E ++ E ++K D EKL + Sbjct: 625 NELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLSELEQLNENLKKVAFDVKMENEKLVL 684 Query: 948 T---KREKLE--------LSQRLSDLSEQLKQKHGEISF--------LNEEVKSLKQEKE 988 R +LE LS + + E LK + GEI L EE ++ E Sbjct: 685 ACEDVRHQLEECLAGNNQLSLEKNTIVETLKMEKGEIEAELCWAKKRLLEEANKYEKTIE 744 Query: 989 QVS----LRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGE 1044 ++S L L++ H N Q D +++ L + M + E + ++ S E Sbjct: 745 ELSNARNLNTSALQLEHEHLIKLN-QKKDMEIAELKKNIEQMDTDHKE-TKDVLSSSLEE 802 Query: 1045 ESKI--MVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRAT----------QPSEN 1092 + ++ ++ K F SK ++ + + ++ K LR T EN Sbjct: 803 QKQLTQLINKKEIFIEKLKERSSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMKEEN 862 Query: 1093 DKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQ---VREYMENE---KDKAL--- 1143 + LQ+EL L+ EQ+ + + + ++ V Q ++E++E E K + Sbjct: 863 NHLQEELERLREEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQ 922 Query: 1144 CSLKEELIFAQEEKIKELQKIHQLELQTMKTQ-----ETGDEGKPLHLLIGKLQKAVSEE 1198 K +L+ + +E+ KE+ + Q T E +E K L I +++ + EE Sbjct: 923 NQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKTIEQIKTQLHEE 982 Query: 1199 CSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHT 1258 + E +L E N +K + +E +++ E++ E + Sbjct: 983 RQDIQTDNSDIFQETKVQSLNIE-NGSEKHDLSKAETERLVKGIKERELEIKLLNEKNIS 1041 Query: 1259 LLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDID 1318 L ++ + + T++ + + + + ++ +L Q +E Sbjct: 1042 LTKQIDQLSKDEVGKLTQIIQQKDLEIQALHARISSTS-HTQDVVYLQQQLQAYAMEREK 1100 Query: 1319 V----NHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQA 1374 V N K++ +S E K+ + V E+ + LQ + K+ L R ++ Sbjct: 1101 VFAVLNEKTRENSHLKTEYHKMMDIVAAKEAALIKLQDENKK-----------LSTRFES 1149 Query: 1375 VSESTVPPSLPVDSVVITESDAQRTMYPGSC-VKKNIDGTIEFSGEFGVKEETNIVKLLE 1433 + ++ S +I E D + C + T E G +LL Sbjct: 1150 SGQDMFRETIQNLSRIIREKDIEIDALSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELL- 1208 Query: 1434 KQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMKL 1493 Q +++L+++V K+ + S + QA + + N KL Sbjct: 1209 -QERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEELHQLQAQVLVDSD----NNSKL 1263 Query: 1494 SQDQIG-FQTFETVDVKFK---EEFKPLSKELGE--HGKEILLSNSDPHD---------I 1538 D G Q++E + K K +E + +G+ + K++LL D Sbjct: 1264 QVDYTGLIQSYEQNETKLKNFGQELAQVQHSIGQLCNTKDLLLGKLDIISPQLSSASLLT 1323 Query: 1539 PESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDAS-RQLMLNEEQLED---MRQEL 1594 P+S +C+ E+ S+ + ++ S+ DA+ R L N +L D EL Sbjct: 1324 PQSAECLRASKSEVLSESSELLQQELEELRKSLQEKDATIRTLQENNHRLSDSIAATSEL 1383 Query: 1595 VRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSE--- 1651 R +EH+Q + ++Q++ +++ ++L +E L + + + NEN ++ Sbjct: 1384 ER--KEHEQT-----DSEIKQLKEKQDVLQKLLKEKDLLIKAKSDQLLSSNENFTNKVNE 1436 Query: 1652 -----------RERVLLEELEALKQLSLAG-REKLCCELRNSSTQTQNGNE--------- 1690 +ER+L+ E++ K L G EK+ R T+ Q E Sbjct: 1437 NELLRQAVTNLKERILILEMDIGK---LKGENEKIVETYRGKETEYQALQETNMKFSMML 1493 Query: 1691 NQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIG 1750 + E E + KEK L + ++L + N+LL + + + T ++ Sbjct: 1494 REKEFECHSMKEKALAFE------QLLKEKEQGKTGELNQLLNAVKSMQEKTVVFQQERD 1547 Query: 1751 RHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINM 1810 + +L + + ++ + + + R + + E ES SY+ + D Sbjct: 1548 QVMLALKQKQMENTALQNEVQRLRDKEFRSNQELERLRNHLLESEDSYTREALAAEDRE- 1606 Query: 1811 WSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEH 1870 +K+ ++ T L ++LV S A M N S + VE L E ++ S Q + Sbjct: 1607 -AKLRKKVTVLEEKLVSSSNA-----------MENASHQASVQVESLQEQLNVVSKQRDE 1654 Query: 1871 AKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADE 1930 + Q + +E +Q + +L+ E H + + + EL K + +I + Sbjct: 1655 TAL-QLSVSQEQVKQYALSLANLQMVLE-----HFQQEEKAMYSAELEKQKQLIAEWKKN 1708 Query: 1931 KTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPV 1990 E ++ + +D L AS ++L+ +++QI+E L RQ E + V Sbjct: 1709 AENLEGKVISLQECLDEANAALDSASRLTEQLDVKEEQIEE----LKRQNELRQEMLDDV 1764 Query: 1991 EQQLL 1995 +++L+ Sbjct: 1765 QKKLM 1769 Score = 124 bits (312), Expect = 1e-27 Identities = 325/1630 (19%), Positives = 688/1630 (42%), Gaps = 247/1630 (15%) Query: 2176 ELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTT- 2234 ++ +E + E + D + KEI + L E L+ ++++ H EIQ K+ +T Sbjct: 36 DMLMEGTEEVEAELPDSRTKEIEAIHAILRSENERLKKLCTDLEEKHEASEIQIKQQSTS 95 Query: 2235 ---RLQELEQENKLFK-------DDMEKLGLAIKESDA-----MSTQDQHVLFG------ 2273 +LQ+ E E K D + KL A + + +T +G Sbjct: 96 YRNQLQQKEVEISHLKARQIALQDQLLKLQSAAQSVPSGAGVPATTASSSFAYGISHHPS 155 Query: 2274 -------KFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECL 2326 F II ++ EI++L+ +V++L+ ++ + +++I L Sbjct: 156 AFHDDDMDFGDIISSQQ-EINRLSNEVSRLESEVGHWRHIAQTSKAQGTDNSDQSEICKL 214 Query: 2327 MSDQECVKRNREEEIEQLNEVIEKL----QQELANIGQKTSMNAHSLSEEADSLKHQLD- 2381 + + +K+NR +EI+ + L QQ+L I ++ E + L++ L Sbjct: 215 QNIIKELKQNRSQEIDDHQHEMSVLQNAHQQKLTEISRRHREELSDYEERIEELENLLQQ 274 Query: 2382 ------------VVIAEKLALEQQVE--TANEEMTFMKNVLKETNFKMNQLTQELFSLKR 2427 + +K Q+E + ++M +++ +K+ N K++ + L+R Sbjct: 275 GGSGVIETDLSKIYEMQKTIQVLQIEKVESTKKMEQLEDKIKDINKKLSSAENDRDILRR 334 Query: 2428 ERE--SVEKIQSIPENSVNVAIDHLSKDKP----------ELEVVLTEDALKSLENQTYF 2475 E+E +VEK Q I E N+ ++ SK +P E E +L + A S+E Sbjct: 335 EQEQLNVEKRQ-IMEECENLKLE-CSKLQPSAVKQSDTMTEKERILAQSA--SVEEVFRL 390 Query: 2476 KSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNL 2535 + + + I+ L + L +++++ +L+L + E+L+K+ L Sbjct: 391 QQALSDAENEIMRLSS--LNQDNSLAEDNLKL--------------KMRIEVLEKEKSLL 434 Query: 2536 QKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDIS- 2594 + EE + L + E ++ A + IS + E +++ + +E EL IS Sbjct: 435 SQEKEELQMSLLKLNNEYEVIKSTA-----TRDISLDSELHDLRLNLEAKEQELNQSISE 489 Query: 2595 --ALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREK 2652 L I EL+ Q E +IL K+Q+ K E + + +L++ L N++K+R Sbjct: 490 KETLIAEIEELDRQNQEATKHMILIKDQL---SKQQNEGDSIISKLKQDL--NDEKKRVH 544 Query: 2653 EKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELL 2712 + + D+ T EL E+ + E + TK +L ++K E L ++L Sbjct: 545 QLEDDKMDI-----TKELDVQKEK---LIQSEVALNDLHLTKQKL---EDKVENLVDQLN 593 Query: 2713 VKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLSKSIAS 2772 + + S+QK+ ++++H+ + +E+LS + E + + + + L + + + Sbjct: 594 KSQESNVSIQKENLELKEHIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRN 653 Query: 2773 QTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTEIISQFTEKIEKMQELHAAEIL 2832 ++ N+ +K + +++E ++ Q E + + L Sbjct: 654 LKQNLSELEQLNEN----LKKVAFDVKMENEKLVLACEDVRHQLEECLAGNNQ------L 703 Query: 2833 DMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREI 2892 +E I ETLK E ++ E C K +++ +K +I EL+++ R + Sbjct: 704 SLEKNTI--VETLKME---KGEIEAELCWAKKRLLE-EANKYEKTIEELSNA-----RNL 752 Query: 2893 CSSDSGSDWGQGIYLTHSQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSL 2952 +S + I L + +IA + E D+ K+ K +L + E Q+ L Sbjct: 753 NTSALQLEHEHLIKLNQKKDMEIAELKKNIEQ---MDTDHKETKDVLSSSLEEQKQLTQL 809 Query: 2953 TESPYSDGEDHSIQQVSEPWLEERKAYI-NTISSLKDLITKMQLQREAEVYDSSQSHESF 3011 +++ L+ER + + + + K ++ R+ + + +S S Sbjct: 810 INK----------KEIFIEKLKERSSKLQEELDKYSQALRKNEILRQT-IEEKDRSLGSM 858 Query: 3012 SDWRGELLLALQQVFLEE-RSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAA 3070 + L L+++ E+ R+ +A +T + V LN +++ ++E+ +Q Sbjct: 859 KEENNHLQEELERLREEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKI 918 Query: 3071 MECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQV 3130 +E Q + LL +Q +M+ + + EQ + +Q LE Sbjct: 919 IED-QNQSKMQLLQSLQEQKKEMD--EFRYQHEQMNATHTQ------------LFLEKDE 963 Query: 3131 ELSSMKDRATELQEQLSSEKMVVAELKSELAQ-TKLELETTLKAQHKH-LKELEAFRL-- 3186 E+ S++ +++ QL E+ + S++ Q TK++ KH L + E RL Sbjct: 964 EIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKAETERLVK 1023 Query: 3187 EVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQ 3246 +K++ E+ LLN+ S K+ +L + E KL + ++ E++ L + S Sbjct: 1024 GIKERELEIKLLNEKNISLTKQIDQLS---KDEVGKLTQIIQQKDLEIQALHARISSTS- 1079 Query: 3247 RNLQLNLLLEQQKQLLNESQQK---IESQRMLYDAQLSEEQGRNLELQVLLESEKVRIRE 3303 + Q + L+QQ Q ++K + +++ ++ L E + +++ E+ ++++ Sbjct: 1080 -HTQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMMDIVAAKEAALIKLQ- 1137 Query: 3304 MSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKL 3363 D ++L + +SS +D+ +E + L SRI+ + ++ Sbjct: 1138 -----DENKKLSTRFESS-----------GQDMFRETIQNL----SRII----REKDIEI 1173 Query: 3364 DSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDL 3423 D+L + Q LQT N G ++ E+L ++ ++ +QQV K++ Sbjct: 1174 DALSQK------CQTLLAVLQTSSTGNEAGGVNSNQF----EELLQERDKLKQQVKKMEE 1223 Query: 3424 EGQRLQGIMQEFQKQ--ELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGE 3481 Q++ +Q Q + +L+ E + ++L + N L D T ++Q + E Sbjct: 1224 WKQQVMTTVQNMQHESAQLQEELHQLQAQVLVDSDNNS---KLQVDYT--GLIQSYEQNE 1278 Query: 3482 TKESNYAKLIE--MNGGGTGCNHELEMIRQKLQCVASKL---QVLPQKASERLQFETAD- 3535 TK N+ + + + G CN + +++ KL ++ +L +L +++E L+ ++ Sbjct: 1279 TKLKNFGQELAQVQHSIGQLCNTK-DLLLGKLDIISPQLSSASLLTPQSAECLRASKSEV 1337 Query: 3536 -DEDFIWVQENIDEIILQLQKLTG---QQGEEPSLVSPSTSCGSLTERLLRQNAELTGHI 3591 E +Q+ ++E+ LQ+ E +S S + S ER +++ + I Sbjct: 1338 LSESSELLQQELEELRKSLQEKDATIRTLQENNHRLSDSIAATSELER--KEHEQTDSEI 1395 Query: 3592 SQLTEEKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREK 3651 QL E+++ L+ ++ + + I+ S L+ N + +E E+ + Sbjct: 1396 KQLKEKQDVLQKLLKEKDLLIK----------AKSDQLLSSNENFTNKV-NENELLRQAV 1444 Query: 3652 LTLQKSLKRAEAEVYKLKAELRNDSLLQTL-SPDSEHVTLKRIYGKY---LRAESF---- 3703 L++ + E ++ KLK E N+ +++T ++E+ L+ K+ LR + F Sbjct: 1445 TNLKERILILEMDIGKLKGE--NEKIVETYRGKETEYQALQETNMKFSMMLREKEFECHS 1502 Query: 3704 --RKALIYQK 3711 KAL +++ Sbjct: 1503 MKEKALAFEQ 1512 >gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens] Length = 1684 Score = 176 bits (447), Expect = 3e-43 Identities = 350/1610 (21%), Positives = 680/1610 (42%), Gaps = 267/1610 (16%) Query: 1906 ESRARE-QLAVELSKAEGVIDGYADEKTLFERQIQEKTD--IIDRLEQELLCASNRLQEL 1962 +SR E + +E +++ V +G D + + E+ D ++++ E E C S + + + Sbjct: 45 KSRCTELEKEIEELRSKPVTEGTGD----IIKALTERLDALLLEKAETEQQCLSLKKENI 100 Query: 1963 EAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQ 2022 + +Q+ ++ KE ++ V+ E E L E + V+ + + + +LQKQ Sbjct: 101 KMKQEVEDSVTKMGDAHKELEQSHINYVK-----EIENLKNELMAVRSKYSEDKANLQKQ 155 Query: 2023 VKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDV 2082 + EE ++ +EL ++ + + + L++++EK+R +EQ + + + D Sbjct: 156 L-------EEAMNTQLELSEQLKFQ-NNSEDNVKKLQEEIEKIRPGFEEQILYLQKQLDA 207 Query: 2083 FQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKE----KTDKCSELLLSKEQLQRD 2138 E ++ QL+ + + S+H + + L L + ++ EL+ Q++ Sbjct: 208 TTDEKKETVTQLQNI--IEANSQHYQKNINSLQEELLQLKAIHQEEVKELMC---QIEAS 262 Query: 2139 IQERNEEIEKLEFRVRELEQALLVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEIT 2198 +E EI KL EL++ L+ + ++ K E LE +A +A ++ +I Sbjct: 263 AKEHEAEINKL----NELKENLVKQCEASEKNIQKKYECELENLRKATSNA--NQDNQIC 316 Query: 2199 NLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDD---MEKLGL 2255 ++ Q F E++ NE+V+ L E T L+ELE ++ + KD+ M L L Sbjct: 317 SILLQENTFVEQV--VNEKVKHL---------EDT--LKELESQHSILKDEVTYMNNLKL 363 Query: 2256 AIKESDAMSTQDQHV-----LFGKFAQIIQEKEVE---IDQLNEQVTKLQQQLKITTD-- 2305 + E DA +D+ L K +++ KE + I++L ++ L +Q T + Sbjct: 364 KL-EMDAQHIKDEFFHEREDLEFKINELLLAKEEQGCVIEKLKSELAGLNKQFCYTVEQH 422 Query: 2306 NKVIEE-KNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQE---------- 2354 N+ ++ K + +++ E +SD E K EI+ L E E LQQE Sbjct: 423 NREVQSLKEQHQKEISELNETFLSDSEKEKLTLMFEIQGLKEQCENLQQEKQEAILNYES 482 Query: 2355 ----LANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKE 2410 + + + +A +S+E +S+K Q + E L+Q++ TA E K+ L E Sbjct: 483 LREIMEILQTELGESAGKISQEFESMKQQQASDVHE---LQQKLRTAFTE----KDALLE 535 Query: 2411 TNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLE 2470 T +N+L E L ++E V ++++ +N +L L + + LK LE Sbjct: 536 T---VNRLQGENEKLLSQQELVPELENTIKNLQEKNGVYL------LSLSQRDTMLKELE 586 Query: 2471 NQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQK 2530 + S E I L+ ++++ + E + K +++ Q+ +E L++ Sbjct: 587 GK--INSLTEEKDDFINKLKNSHEEMDNFHKKCEREERLILELGKKVEQTIQYNSE-LEQ 643 Query: 2531 KIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLRED--E 2588 K+ L +EE + + +LE + K +++ + S ++ + N+L + + Sbjct: 644 KVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQ 703 Query: 2589 LGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKL-----LE 2643 L D+ +S+ E +++ H + + +K Q+ + E++ L K + ++QKL L Sbjct: 704 LSRDLEVF---LSQKEDVILKEHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLY 760 Query: 2644 G--NEKKQREKEKKRSPQDVEVLKTTTE-LFHSNEES------------GFFNELEALRA 2688 G E E V VL+ E L NEE E++ L+ Sbjct: 761 GFLKEMGSEVSEDSEEKDVVNVLQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQE 820 Query: 2689 ESVATKAELAS----YKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLS---- 2740 ESV EL S Y+++ L++EL ++ +LQ DL ++++ A K +L Sbjct: 821 ESVVQCEELKSLLRDYEQEKVLLRKELEEIQSEKEALQSDLLEMKN--ANEKTRLENQNL 878 Query: 2741 ILEKED------ETEVQESKKACMFEP----LPIKLSKSIASQ-------TDGTLKISSS 2783 +++ E+ ++E+ K+ C + P+ K + + D K S Sbjct: 879 LIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSV 938 Query: 2784 NQTPQILVKNAGIQI-NLQSECSSEEVTEIISQFTEKIEKMQELHAAEILDMESRHISET 2842 P VK +I NL+ EC +E EKI K++ + +++S ET Sbjct: 939 KNDPLSSVKELEEKIENLEKECKEKE---------EKINKIKLVAVKAKKELDSSR-KET 988 Query: 2843 ETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREICSSDSGSDWG 2902 +T+K E ++ L+ E L A ++ L + +++Y+ + Sbjct: 989 QTVKEE----LESLRSEKDQLSASMRDL----------IQGAESYKNLLL---------- 1024 Query: 2903 QGIYLTHSQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGED 2962 Y S+ D+ E ++F +I+ L R + N +Q E+ SD ED Sbjct: 1025 --EYEKQSEQLDVEKE--------RANNFEHRIEDLTRQLRNSTLQ----CETINSDNED 1070 Query: 2963 HSIQQVSEPWLEERKAYINTISSLKDL--ITKMQLQREAEVYDSSQSHESFSDWRGELLL 3020 A I T+ S L + +++QR + D E + Sbjct: 1071 -------------LLARIETLQSNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIKEH 1117 Query: 3021 ALQQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRR 3080 A LEE V L + +L T + L+ Q Q + ++ AD Sbjct: 1118 ATTVNELEELQVQLQKEKKQLQK--TMQELELVKKDAQ---------QTTLMNMEIADYE 1166 Query: 3081 SLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRAT 3140 L+ E+ N + L++E + +K QE L+ I QS + + + + + +K Sbjct: 1167 RLMKELNQKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQLLV 1226 Query: 3141 ELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLND 3200 + +++L+ K + A K ELE + +++E +++++ + T E H +++ Sbjct: 1227 KTKKELADSKQAETDHLILQASLKGELEAS-------QQQVEVYKIQLAEITSEKHKIHE 1279 Query: 3201 TLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQ 3260 L + ++ + A ++ L K E + ES K R ++ +L+QQK Sbjct: 1280 HLKTSAEQHQRTLSAYQQRVTALQEECRAAKAEQATVTSEFESYKVR---VHNVLKQQK- 1335 Query: 3261 LLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQS 3320 N+S + E++ + + L++L++ K+++++ + L LQS Sbjct: 1336 --NKSMSQAETEGAKQERE---------HLEMLIDQLKIKLQDSQNNLQINVSELQTLQS 1384 Query: 3321 SDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQM---EKDRQ 3377 T LL+ K L+E S+ EL + KL S+Q+ M E + Sbjct: 1385 EHDT-----------LLERHNKMLQETVSKEAEL-----REKLCSIQSENMMMKSEHTQT 1428 Query: 3378 VHRKTLQTEQEANTEGQKKMH---ELQSKVEDLQRQLEEKRQQVYKLDLE 3424 V + T Q E N+ + H E + VE LQ+QL + Q+++L E Sbjct: 1429 VSQLTSQNEVLRNSFRDQVRHLQEEHRKTVETLQQQLSKMEAQLFQLKNE 1478 Score = 173 bits (439), Expect = 3e-42 Identities = 364/1699 (21%), Positives = 713/1699 (41%), Gaps = 303/1699 (17%) Query: 1941 KTDIIDRLEQELLC---ASNRLQELEAEQQQIQEER---------ELLSRQKEAMKAEAG 1988 K D+I +++++ A +R ELE E ++++ + + L+ + +A+ E Sbjct: 27 KEDLIKFAKKQMMLIQKAKSRCTELEKEIEELRSKPVTEGTGDIIKALTERLDALLLEKA 86 Query: 1989 PVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTEL 2048 EQQ L ++ +K K EV+ K+ D K LE + ++ E+E KN EL Sbjct: 87 ETEQQCLSLKKENIKMKQEVEDSVTKMGD----AHKELE---QSHINYVKEIENLKN-EL 138 Query: 2049 MDLR----QQNQALEKQLEKMRKF---LDEQAIDREHERDVFQQEIQKLEQQL-KVVPRF 2100 M +R + L+KQLE+ L EQ + + D ++KL++++ K+ P F Sbjct: 139 MAVRSKYSEDKANLQKQLEEAMNTQLELSEQLKFQNNSED----NVKKLQEEIEKIRPGF 194 Query: 2101 QPISEHQTREVEQLANHLKEKTDKCSELLLSKEQ-LQRDIQERNEEIEKLEF----RVRE 2155 + + ++++ + KE + ++ + Q Q++I EE+ +L+ V+E Sbjct: 195 EEQILYLQKQLDATTDEKKETVTQLQNIIEANSQHYQKNINSLQEELLQLKAIHQEEVKE 254 Query: 2156 LEQALLVEDRKHFGAVEAKPEL--SLEVQLQAERDAIDRK-EKEITNLEEQLEQFREE-- 2210 L + ++H + EL +L Q +A I +K E E+ NL + ++ Sbjct: 255 LMCQIEASAKEHEAEINKLNELKENLVKQCEASEKNIQKKYECELENLRKATSNANQDNQ 314 Query: 2211 ----LENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLG-LAIK-ESDAMS 2264 L +N V+Q+ + +++ E T L+ELE ++ + KD++ + L +K E DA Sbjct: 315 ICSILLQENTFVEQV-VNEKVKHLEDT--LKELESQHSILKDEVTYMNNLKLKLEMDAQH 371 Query: 2265 TQDQHV-----LFGKFAQIIQEKEVE---IDQLNEQVTKLQQQLKITTD--NKVIEE-KN 2313 +D+ L K +++ KE + I++L ++ L +Q T + N+ ++ K Sbjct: 372 IKDEFFHEREDLEFKINELLLAKEEQGCVIEKLKSELAGLNKQFCYTVEQHNREVQSLKE 431 Query: 2314 ELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQE--------------LANIG 2359 + +++ E +SD E K EI+ L E E LQQE + + Sbjct: 432 QHQKEISELNETFLSDSEKEKLTLMFEIQGLKEQCENLQQEKQEAILNYESLREIMEILQ 491 Query: 2360 QKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLT 2419 + +A +S+E +S+K Q + E L+Q++ TA E K+ L ET +N+L Sbjct: 492 TELGESAGKISQEFESMKQQQASDVHE---LQQKLRTAFTE----KDALLET---VNRLQ 541 Query: 2420 QELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFE 2479 E L ++E V ++++ +N +L L + + LK LE + S Sbjct: 542 GENEKLLSQQELVPELENTIKNLQEKNGVYL------LSLSQRDTMLKELEGK--INSLT 593 Query: 2480 ENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIV 2539 E I L+ ++++ + E + K +++ Q+ +E L++K+ L + Sbjct: 594 EEKDDFINKLKNSHEEMDNFHKKCEREERLILELGKKVEQTIQYNSE-LEQKVNELTGGL 652 Query: 2540 EEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLRED--ELGSDISALT 2597 EE + + +LE + K +++ + S ++ + N+L + +L D+ Sbjct: 653 EETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVF- 711 Query: 2598 LRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLE-----------GNE 2646 +S+ E +++ H + + +K Q+ + E++ L K + ++QKL G+E Sbjct: 712 --LSQKEDVILKEHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSE 769 Query: 2647 KKQREKEKKRSPQDVEVLKTTTE-LFHSNEES------------GFFNELEALRAESVAT 2693 + +EK V VL+ E L NEE E++ L+ ESV Sbjct: 770 VSEDSEEK----DVVNVLQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEESVVQ 825 Query: 2694 KAELAS----YKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAK-EKLSILEKEDE- 2747 EL S Y+++ L++EL ++ +LQ DL ++++ + + E ++L + +E Sbjct: 826 CEELKSLLRDYEQEKVLLRKELEEIQSEKEALQSDLLEMKNANEKTRLENQNLLIQVEEV 885 Query: 2748 ------TEVQESKKACMFEP----LPIKLSKSIASQT-------DGTLKISSSNQTPQIL 2790 +E+ K+ C + P+ K + + D K S P Sbjct: 886 SQTCSKSEIHNEKEKCFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKNDPLSS 945 Query: 2791 VKNAGIQI-NLQSECSSEEVTEIISQFTEKIEKMQELHAAEILDMESRHISETETLKREH 2849 VK +I NL+ EC +E EKI K++ + +++S ET+T+K E Sbjct: 946 VKELEEKIENLEKECKEKE---------EKINKIKLVAVKAKKELDSSR-KETQTVKEE- 994 Query: 2850 YVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREICSSDSGSDWGQGIYLTH 2909 ++ L+ E L A ++ L + +++Y+ + Y Sbjct: 995 ---LESLRSEKDQLSASMRDL----------IQGAESYKNLLL------------EYEKQ 1029 Query: 2910 SQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVS 2969 S+ D+ E ++F +I+ L R + N +Q E+ SD ED Sbjct: 1030 SEQLDVEKE--------RANNFEHRIEDLTRQLRNSTLQC----ETINSDNED------- 1070 Query: 2970 EPWLEERKAYINTISSLKDLITK--MQLQREAEVYDSSQSHESFSDWRGELLLALQQVFL 3027 A I T+ S L+ +++QR + D E + A L Sbjct: 1071 ------LLARIETLQSNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNEL 1124 Query: 3028 EERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQ 3087 EE V L + +L + L +++ Q Q + ++ AD L+ E+ Sbjct: 1125 EELQVQLQKEKKQLQK-----TMQELELVKKDAQ------QTTLMNMEIADYERLMKELN 1173 Query: 3088 ALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLS 3147 N + L++E + +K QE L+ I QS + + + + + +K + +++L+ Sbjct: 1174 QKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELA 1233 Query: 3148 SEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLND------- 3200 K + A K ELE + + ++E +++++ + T E H +++ Sbjct: 1234 DSKQAETDHLILQASLKGELEASQQ-------QVEVYKIQLAEITSEKHKIHEHLKTSAE 1286 Query: 3201 ----TLASEQKKSRELQW---ALEKEKAKLGRSEERDKEELEDL----------KFSLES 3243 TL++ Q++ LQ A + E+A + E K + ++ + E Sbjct: 1287 QHQRTLSAYQQRVTALQEECRAAKAEQATVTSEFESYKVRVHNVLKQQKNKSMSQAETEG 1346 Query: 3244 QKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIRE 3303 KQ L +L++Q K L +SQ ++ +SE Q E LLE ++E Sbjct: 1347 AKQEREHLEMLIDQLKIKLQDSQNNLQ-------INVSELQTLQSEHDTLLERHNKMLQE 1399 Query: 3304 MSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKL 3363 T+ +E EL +L S + SE+++ ++ +H++ V L + Sbjct: 1400 ---TVSKEAELREKLCS----------IQSENMM------MKSEHTQTVSQLTSQNEVLR 1440 Query: 3364 DSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQ---------SKVEDLQRQLEEK 3414 +S R Q+ ++ HRKT++T Q+ ++ + ++ +L+ S + L+ E + Sbjct: 1441 NSF--RDQVRHLQEEHRKTVETLQQQLSKMEAQLFQLKNEPTTRSPVSSQQSLKNLRERR 1498 Query: 3415 RQQVYKLDL------EGQRLQGIMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSDR 3468 + LD+ EG+ ++ E + E + EP W + Sbjct: 1499 NTDLPLLDMHTVTREEGEGMETTDTESVSSASTYTQSLEQLLNSPETKLEPPLWHAEFTK 1558 Query: 3469 TRNWVLQQKIEGETKESNY 3487 L QK+ TK +++ Sbjct: 1559 EE---LVQKLSSTTKSADH 1574 Score = 167 bits (422), Expect = 2e-40 Identities = 359/1713 (20%), Positives = 725/1713 (42%), Gaps = 282/1713 (16%) Query: 173 ELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELT 232 EL +E+EE+R TEG II LT L EK ET ++ L L Sbjct: 50 ELEKEIEELRSKPVTEG-------------TGDIIKALTERLDALLLEKAETEQQCLSLK 96 Query: 233 EQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEE-QDHLLEDYQKKK 291 +++ K++ Q+++ S T H + +Q + + +++E ++ L+ K Sbjct: 97 KENIKMK---QEVEDSVTKMGDAHK-------ELEQSHINYVKEIENLKNELMAVRSKYS 146 Query: 292 EDFTMQISFLQEKIKV-YEMEQDKKVENSNKEEIQEKETIIEELNTKIIEE--------E 342 ED L+E + E+ + K +N++++ +++ + IE++ E+ + Sbjct: 147 EDKANLQKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQKQLD 206 Query: 343 KKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVE 402 T E K+ +T ++ E Q QKN I +++ EL K + EE+K+LM +E Sbjct: 207 ATTDEKKETVTQLQNII-EANSQHYQKN--INSLQEELLQLKAIHQ---EEVKELMCQIE 260 Query: 403 ELQKRN----HKDSQFETDIVQRMEQETQRKLEQLRAELDEM-----YGQQIVQMKQELI 453 K + +K ++ + ++V++ E + ++ EL+ + Q Q+ L+ Sbjct: 261 ASAKEHEAEINKLNELKENLVKQCEASEKNIQKKYECELENLRKATSNANQDNQICSILL 320 Query: 454 RQH--MAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNS---- 507 +++ + Q+ K +H + L S +I +D++ MN +L + Q Sbjct: 321 QENTFVEQVVNEKVKHLEDTLKELESQHSIL--KDEVTYMNNLKLKLEMDAQHIKDEFFH 378 Query: 508 QKEKL----------KEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQE-- 555 ++E L KEE G ++E+ L+ +L L ++ ++ EQ R Q++ EQ Sbjct: 379 EREDLEFKINELLLAKEEQGCVIEK---LKSELAGLNKQFCYTVEQHNREVQSLKEQHQK 435 Query: 556 --SKLNEAHKSLSTVEDLKA--EIVSASESRKELELKHEAEVTNYKIKLEMLE------- 604 S+LNE S S E L EI E + L+ + + + NY+ E++E Sbjct: 436 EISELNETFLSDSEKEKLTLMFEIQGLKEQCENLQQEKQEAILNYESLREIMEILQTELG 495 Query: 605 -------KEKNAVLDRMAESQEAELERLRT-------------QLLFSHEEELSKLKEDL 644 +E ++ + A ++LRT +L +E+ LS+ + Sbjct: 496 ESAGKISQEFESMKQQQASDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQELVP 555 Query: 645 EIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITK------------- 691 E+E+ I + K+ + + Q D + E+ KI ++ EKD+ I K Sbjct: 556 ELENTIKNLQEKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEEMDNFHK 615 Query: 692 ----QNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQE 747 + +LILE+ K K Q NS+ E+ ++NEL +E + KEK +Q++++ Sbjct: 616 KCEREERLILELGK-KVEQTIQYNSELEQ---KVNELTGGLE---ETLKEKDQNDQKLEK 668 Query: 748 LQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLD 807 L ++ ++L E + L + L EN+ L EKK L L++ +SQ+E +I + Sbjct: 669 LMVQMKVL----SEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVF--LSQKEDVILKE 722 Query: 808 SIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEK---QRNTFSF------------ 852 I + EK++++++EE ++L + + NE+++K + + F Sbjct: 723 HI------TQLEKKLQLMVEEQDNLNK--LLENEQVQKLFVKTQLYGFLKEMGSEVSEDS 774 Query: 853 AEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKM 912 EK+ Q + E A + + K +L ++++ LE + ++K L EE +Q ++ Sbjct: 775 EEKDVVNVLQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEESVVQ-----CEEL 829 Query: 913 KSSV--FDEDKTFVAETLE----MGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQL 966 KS + ++++K + + LE E ++ D E+ E T+ E L ++ ++S+ Sbjct: 830 KSLLRDYEQEKVLLRKELEEIQSEKEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTC 889 Query: 967 KQ----KHGEISFLNEEVKSLKQEKEQVSLRCRELE-IIINHNRAENVQSCDTQVSSL-- 1019 + E F+ E ++LK EQ LR R E I++ + A++ + +SS+ Sbjct: 890 SKSEIHNEKEKCFIKEH-ENLKPLLEQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKE 948 Query: 1020 LDGVVTMTSRGAEGSVSKVNKSFGEESKIMVE-DKVSFENMTVGEESKQEQLILDHLPSV 1078 L+ + + + K+NK K E D E TV EE + + D L S Sbjct: 949 LEEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEKDQL-SA 1007 Query: 1079 TKESSLRATQPSEN-----DKLQKELNVLKSEQN-------DLRLQMEAQRICLSLVYST 1126 + ++ + +N +K ++L+V K N DL Q+ + + S Sbjct: 1008 SMRDLIQGAESYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETINSD 1067 Query: 1127 HVD---QVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKP 1183 + D ++ N K + L+ + A +K E +K+ Q E + + T +E + Sbjct: 1068 NEDLLARIETLQSNAKLLEVQILEVQRAKAMVDKELEAEKL-QKEQKIKEHATTVNELEE 1126 Query: 1184 LHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISE---NEDP 1240 L + + K +K + + +Q L V + L + D E +++ N++ Sbjct: 1127 LQVQLQKEKKQLQKT----MQELELVKKDAQQTTL-MNMEIADYERLMKELNQKLTNKNN 1181 Query: 1241 ELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKE 1300 +++D E++ ++ TL ++T + + + + +KI ++ L K Sbjct: 1182 KIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKI-------------KQLLVKT 1228 Query: 1301 ETEFLSIHSQMTNLEDIDVNHKSKL-SSLQDLEKTKLEEQVQELESLISSLQQQLKETEQ 1359 + E T+ + + K +L +S Q +E K+ Q+ E+ S + + LK + + Sbjct: 1229 KKELADSKQAETDHLILQASLKGELEASQQQVEVYKI--QLAEITSEKHKIHEHLKTSAE 1286 Query: 1360 NYEAEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGE 1419 ++ + Q+R+ A+ E + + +T + + +K+ + ++ + Sbjct: 1287 QHQRTLSAYQQRVTALQEEC--RAAKAEQATVTSEFESYKVRVHNVLKQQKNKSMSQAET 1344 Query: 1420 FGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTE---------------LSRI 1464 G K+E +++L Q + +L++ + +++S Q+E +S+ Sbjct: 1345 EGAKQEREHLEMLIDQLKIKLQDSQNNLQINVSELQTLQSEHDTLLERHNKMLQETVSKE 1404 Query: 1465 SGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFK----PLSKE 1520 + +E S + + + + E SQ+++ +F +EE + L ++ Sbjct: 1405 AELREKLCSIQSENMMMKSEHTQTVSQLTSQNEVLRNSFRDQVRHLQEEHRKTVETLQQQ 1464 Query: 1521 LGEHGKEIL-LSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDE----------- 1568 L + ++ L N P S L E + D + ++ E Sbjct: 1465 LSKMEAQLFQLKNEPTTRSPVSSQQSLKNLRERRNTDLPLLDMHTVTREEGEGMETTDTE 1524 Query: 1569 --ISVSSMDASRQLMLNEEQ---------LEDMRQELVRQYQEHQQATELLRQAHMRQME 1617 S S+ S + +LN + E ++ELV++ ++ + L +R+ E Sbjct: 1525 SVSSASTYTQSLEQLLNSPETKLEPPLWHAEFTKEELVQKLSSTTKSADHL-NGLLRETE 1583 Query: 1618 RQR----EDQEQLQEEIKRLNRQLAQRSSIDN----ENLV---------SERERVLLEEL 1660 E + L+ EI+RL R + S N +N++ SERER LL + Sbjct: 1584 ATNAILMEQIKLLKSEIRRLERNQEREKSAANLEYLKNVLLQFIFLKPGSERER-LLPVI 1642 Query: 1661 EALKQLSLAGREKLCCELRNSSTQTQNGNENQG 1693 + QLS + KL + + +N + + G Sbjct: 1643 NTMLQLSPEEKGKLAAVAQG---EEENASRSSG 1672 Score = 162 bits (410), Expect = 6e-39 Identities = 298/1334 (22%), Positives = 554/1334 (41%), Gaps = 209/1334 (15%) Query: 92 ITSHEQGFSVE-LESEISTTADDCSSEVNGCSFVMRTGKPTNLLREEEFGVDDSYSEQGA 150 + EQG +E L+SE++ C V + + L+E+ +E Sbjct: 392 LAKEEQGCVIEKLKSELA------GLNKQFCYTVEQHNREVQSLKEQHQKEISELNETFL 445 Query: 151 QDSPTHLEMMESELAGKQHEIEELNRELEEMRVTYGTEGLQQL----------------Q 194 DS + E+ G + + E L +E +E + Y E L+++ Q Sbjct: 446 SDSEKEKLTLMFEIQGLKEQCENLQQEKQEAILNY--ESLREIMEILQTELGESAGKISQ 503 Query: 195 EFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQIQFQQLQASETLRNS 254 EFE+ +Q+ + +L L+ A EKD + L +++KL Q + + E + Sbjct: 504 EFESMKQQQASDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQELVPELENTIKN 563 Query: 255 THSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDK 314 LL Q+ L+E + + ++K+DF ++ + Sbjct: 564 LQEKNGVYLLSLSQR----DTMLKELEGKINSLTEEKDDFINKLK-----------NSHE 608 Query: 315 KVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIK 374 +++N +K + + +E +I EL K+ + + EL+ K+ ++L G L+E + +K+Q Sbjct: 609 EMDNFHK-KCEREERLILELGKKVEQTIQYNSELEQKV---NELTGGLEETLKEKDQ--N 662 Query: 375 NMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLR 434 + KLE + K +E+ L V+ L + N+K S + +QL Sbjct: 663 DQKLEKLMVQMKVLSEDKEV--LSAEVKSLYEENNKLSS---------------EKKQLS 705 Query: 435 AELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVA 494 +L+ Q+ + ++++H+ Q+E+ E +N + N V + +K Sbjct: 706 RDLEVFLSQK----EDVILKEHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYG 761 Query: 495 -INELNIKLQDTNSQKEKLK------EELGLILEEKCALQRQLEDLVEELSFSREQIQRA 547 + E+ ++ + + +K+ + E L I EEKC L Q ++ V EL Sbjct: 762 FLKEMGSEVSEDSEEKDVVNVLQAVGESLAKINEEKCNLAFQRDEKVLEL---------- 811 Query: 548 RQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEK 607 E+E K L+ E V E K L +E E + +LE ++ EK Sbjct: 812 -----EKEIKC------------LQEESVVQCEELKSLLRDYEQEKVLLRKELEEIQSEK 854 Query: 608 NAVLDRMAESQEA-ELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQ 666 A+ + E + A E RL Q L EE+S+ EI + EK K + H Sbjct: 855 EALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIHN----EKEKCFIKEH---- 906 Query: 667 IDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQK 726 + L+ + QK L ++ +LIL LKD + K++ ++ + EL++ Sbjct: 907 -ENLKPLLEQK---------ELRDRRAELIL----LKDSLAKSPSVKNDPLS-SVKELEE 951 Query: 727 EIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKT 786 +IE L +E KEK E+++ +++L +K++ + Q +LE+ L+ EK Sbjct: 952 KIENLEKECKEK---EEKINKIKLVAVKAKKELDSSRKETQTVKEELES----LRSEKDQ 1004 Query: 787 LEDMLKIHTPVSQEERLIFLDSIK-------SKSKDSVWEKEIEILIEENEDLKQQCIQL 839 L ++ ++ + + L+ K K + + +E IE L + + QC + Sbjct: 1005 LSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETI 1064 Query: 840 ---NEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKAL 896 NE++ + T K EV E+Q A V +LE K ++E + K + Sbjct: 1065 NSDNEDLLARIETLQSNAKLLEVQILEVQRAKA---MVDKELEAEKLQKEQKIKEHATTV 1121 Query: 897 N--EELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTE-LMEKLEVTKREKL 953 N EEL +Q ++K + +T++ E+V+KD + + +E+ E+L Sbjct: 1122 NELEELQVQ-------------LQKEKKQLQKTMQELELVKKDAQQTTLMNMEIADYERL 1168 Query: 954 ELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCD 1013 + +L+++L K+ +I L +E+K KQ++E + L+ + +N + Sbjct: 1169 -----MKELNQKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQ 1223 Query: 1014 TQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILD 1073 V + + S+ AE + S E + + +V + + E + ++ I + Sbjct: 1224 LLVKTKKE---LADSKQAETDHLILQASLKGELEAS-QQQVEVYKIQLAEITSEKHKIHE 1279 Query: 1074 HL-PSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVR 1132 HL S + + LQ+E K+EQ + + E+ ++ + V ++ Sbjct: 1280 HLKTSAEQHQRTLSAYQQRVTALQEECRAAKAEQATVTSEFESYKVRVHNVLKQQKNKSM 1339 Query: 1133 EYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQ 1192 E E K E LI + K+++ Q Q+ + ++T ++ + L LQ Sbjct: 1340 SQAETEGAKQEREHLEMLIDQLKIKLQDSQNNLQINVSELQTLQS-EHDTLLERHNKMLQ 1398 Query: 1193 KAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYEVQDF 1252 + VS+E + LCS+ E + +E + S+NE +R +V+ Sbjct: 1399 ETVSKEAE-LREKLCSIQSE------NMMMKSEHTQTVSQLTSQNEVLR-NSFRDQVRHL 1450 Query: 1253 QE----NMHTLLNKVTEEYNKLLVLQ---TRLSKIWGQQ----------TD----GMKLE 1291 QE + TL ++++ +L L+ T S + QQ TD M Sbjct: 1451 QEEHRKTVETLQQQLSKMEAQLFQLKNEPTTRSPVSSQQSLKNLRERRNTDLPLLDMHTV 1510 Query: 1292 FGEENLPKEETEFLSIHSQMT---NLEDIDVNHKSKLS-SLQDLEKTKLEEQVQELESLI 1347 EE E T+ S+ S T +LE + + ++KL L E TK EE VQ+L S Sbjct: 1511 TREEGEGMETTDTESVSSASTYTQSLEQLLNSPETKLEPPLWHAEFTK-EELVQKLSSTT 1569 Query: 1348 SS---LQQQLKETE 1358 S L L+ETE Sbjct: 1570 KSADHLNGLLRETE 1583 Score = 160 bits (406), Expect = 2e-38 Identities = 358/1793 (19%), Positives = 744/1793 (41%), Gaps = 246/1793 (13%) Query: 203 RDGIITQLTANLQQARRE---KDETMREFLELTEQSQKLQIQFQQLQAS-ETLRNSTHSS 258 +DG+ + T +++ E K++ ++ + QK + + +L+ E LR+ + Sbjct: 6 QDGVASPATPGTGKSKLETLPKEDLIKFAKKQMMLIQKAKSRCTELEKEIEELRSKPVTE 65 Query: 259 TAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVEN 318 D+++A + L LE+ + + KKE+ M+ K+ + K++E Sbjct: 66 GTGDIIKALTERLD-ALLLEKAETEQQCLSLKKENIKMKQEVEDSVTKMGDAH--KELEQ 122 Query: 319 SNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKL 378 S+ ++E E + EL + + L+ +L A EL EQ+ +N N+K Sbjct: 123 SHINYVKEIENLKNELMAVRSKYSEDKANLQKQLEEAMNTQLELSEQLKFQNNSEDNVK- 181 Query: 379 ELTNSKQKERQSSEE-----IKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQL 433 +L +K R EE KQL T +E + +Q + +I++ Q Q+ + L Sbjct: 182 KLQEEIEKIRPGFEEQILYLQKQLDATTDE---KKETVTQLQ-NIIEANSQHYQKNINSL 237 Query: 434 RAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNV 493 + EL Q+ + QE +++ M Q+E H+ E+ N L V + + N+ Sbjct: 238 QEEL-----LQLKAIHQEEVKELMCQIEASAKEHEAEI-NKLNELKENLVKQCEASEKNI 291 Query: 494 AINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAE 553 + +L++ ++ + C++ Q VE++ E+++ T+ E Sbjct: 292 Q-KKYECELENLRKATSNANQD-----NQICSILLQENTFVEQV--VNEKVKHLEDTLKE 343 Query: 554 QESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDR 613 ES+ + ++ + +LK ++ ++ K+ E HE E +KI +L KE+ + Sbjct: 344 LESQHSILKDEVTYMNNLKLKLEMDAQHIKD-EFFHEREDLEFKINELLLAKEEQGCVIE 402 Query: 614 MAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDN-LGIHYKQQIDGLQN 672 +S+ A L + + H E+ LKE +H+ I +L + L K+++ Sbjct: 403 KLKSELAGLNKQFCYTVEQHNREVQSLKE----QHQKEISELNETFLSDSEKEKL----- 453 Query: 673 EMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILR 732 + +I+ ++ + +NL ++ + IL L+++ + L E+ ++ +E E ++ Sbjct: 454 TLMFEIQGLKEQCENLQQEKQEAILNYESLREIMEIL----QTELGESAGKISQEFESMK 509 Query: 733 QEEKEKGTLEQEVQELQ--LKTELLEKQ-MKEKENDLQEKFAQLEAENSILKDEKKTLED 789 Q++ +V ELQ L+T EK + E N LQ + +L ++ ++ + + T+++ Sbjct: 510 QQQ------ASDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQELVPELENTIKN 563 Query: 790 MLKIHTPVSQEERLIFLDSIKSK-SKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRN 848 + QE+ ++L S+ + + E +I L EE +D + +EE++ N Sbjct: 564 L--------QEKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEEMD---N 612 Query: 849 TFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPT 908 E+ E EL ++ ++ +LE N+ + LK ++ + Q++ Sbjct: 613 FHKKCERE-ERLILELGKKVEQTIQYNSELEQKVNELTGGLEETLK--EKDQNDQKLEKL 669 Query: 909 TVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLS-DLSEQLK 967 V+MK V EDK + + E+ + E++ EK ++++ ++ LSQ+ L E + Sbjct: 670 MVQMK--VLSEDKEVL--SAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHIT 725 Query: 968 QKHGEISFLNEEVKSLKQ--EKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVT 1025 Q ++ + EE +L + E EQV + ++ + S D++ +++ + Sbjct: 726 QLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQA 785 Query: 1026 MTSRGAEGSVSKVNKSFGEESKIMVEDK----VSFENMTVGEESKQEQLILDH-LPSVTK 1080 + A+ + K N +F + K++ +K + E++ EE K L+ D+ V Sbjct: 786 VGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEELK--SLLRDYEQEKVLL 843 Query: 1081 ESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKD 1140 L Q SE + LQ +L +K+ RL+ + I + V T + + NEK+ Sbjct: 844 RKELEEIQ-SEKEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQT---CSKSEIHNEKE 899 Query: 1141 KALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECS 1200 K E L E+K ++ + L+ + + PL + +L++ + Sbjct: 900 KCFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKNDPLS-SVKELEEKIEN--- 955 Query: 1201 YFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLL 1260 L+ C E V A+ + +S ++ EL+ R E +M L+ Sbjct: 956 --LEKECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEKDQLSASMRDLI 1013 Query: 1261 NKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVN 1320 N LL + + ++ ++ E E+L ++ + + E I+ + Sbjct: 1014 QGAESYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQ------LRNSTLQCETINSD 1067 Query: 1321 HKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSESTV 1380 ++ L+ ++ L+ +VQ LE +Q+ ++ EAE LQK + +T Sbjct: 1068 NEDLLARIETLQSNAKLLEVQILE-----VQRAKAMVDKELEAE--KLQKEQKIKEHATT 1120 Query: 1381 PPSLPVDSVVI--TESDAQRTMYPGSCVKKNIDGTIEFSGEFG------------VKEET 1426 L V + + Q+TM VKK+ T + E + + Sbjct: 1121 VNELEELQVQLQKEKKQLQKTMQELELVKKDAQQTTLMNMEIADYERLMKELNQKLTNKN 1180 Query: 1427 NIVKLLE------KQYQEQLEEEVAKVIVSMSIAFAQQTELSR-ISGGKENTASSKQA-- 1477 N ++ LE KQ QE L+EE+ + S+ + T++ + + K+ A SKQA Sbjct: 1181 NKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQAET 1240 Query: 1478 -HAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPH 1536 H + Q E++ SQ Q+ + ++ ++ ++ EH L ++++ H Sbjct: 1241 DHLILQASLK--GELEASQQQVEVYKIQLAEITSEKH------KIHEH----LKTSAEQH 1288 Query: 1537 D--IPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQEL 1594 + + V + EE R + ++ +V+S S ++ ++ Sbjct: 1289 QRTLSAYQQRVTALQEE---------CRAAKAEQATVTSEFESYKVRVHNVL-------- 1331 Query: 1595 VRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIK----------RLNRQLAQRSSID 1644 QQ + + QA +++RE E L +++K ++N Q + Sbjct: 1332 ------KQQKNKSMSQAETEGAKQEREHLEMLIDQLKIKLQDSQNNLQINVSELQTLQSE 1385 Query: 1645 NENLVSERERVLLEELEALKQLSLAGREKLC------CELRNSSTQTQNGNENQGEVEEQ 1698 ++ L+ ++L E + +L REKLC +++ TQT + +Q EV Sbjct: 1386 HDTLLERHNKMLQETVSKEAEL----REKLCSIQSENMMMKSEHTQTVSQLTSQNEVLRN 1441 Query: 1699 TFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILD 1758 +F+++ + E R ++ +L K+ ++ + L Sbjct: 1442 SFRDQVRHLQEE---------HRKTVETLQQQLSKMEAQLFQ----------------LK 1476 Query: 1759 RSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEG 1818 ++S S ++ S+K+ +T D+P D++ ++ EG Sbjct: 1477 NEPTTRSPVS------SQQSLKNLRERRNT-------------DLPLLDMHTVTREEGEG 1517 Query: 1819 TELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAV-------EKLLEAISETSSQLEHA 1871 E + S + + E+L+ + ++L+ + E+L++ +S T+ +H Sbjct: 1518 METTD--TESVSSASTYTQSLEQLLNSPETKLEPPLWHAEFTKEELVQKLSSTTKSADHL 1575 Query: 1872 KVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVI 1924 L+RE+ E +K + RL E ++ RE+ A L + V+ Sbjct: 1576 ----NGLLRETEATNAILMEQIKLLKSEIRRL-ERNQEREKSAANLEYLKNVL 1623 Score = 159 bits (401), Expect = 7e-38 Identities = 317/1648 (19%), Positives = 697/1648 (42%), Gaps = 217/1648 (13%) Query: 2016 RDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQN---------QALEKQLEKM- 2065 ++DL K K + +++ SR ELE+E + +LR + +AL ++L+ + Sbjct: 27 KEDLIKFAKKQMMLIQKAKSRCTELEKE----IEELRSKPVTEGTGDIIKALTERLDALL 82 Query: 2066 --RKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISE---HQTREVEQLANHLKE 2120 + ++Q + + E +QE++ + K+ + + + + +E+E L N L Sbjct: 83 LEKAETEQQCLSLKKENIKMKQEVE--DSVTKMGDAHKELEQSHINYVKEIENLKNELMA 140 Query: 2121 KTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVEDRKHFGAVEAKPELSLE 2180 K SE K LQ+ ++E A+ + ELS + Sbjct: 141 VRSKYSE---DKANLQKQLEE----------------------------AMNTQLELSEQ 169 Query: 2181 VQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEI---QKKESTTRLQ 2237 ++ Q + E + L+E++E+ R E E++ L QL+ +KKE+ T+LQ Sbjct: 170 LKFQ------NNSEDNVKKLQEEIEKIRPGFE---EQILYLQKQLDATTDEKKETVTQLQ 220 Query: 2238 EL-EQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKL 2296 + E ++ ++ ++ L + + A+ ++ L + +E E EI++LNE L Sbjct: 221 NIIEANSQHYQKNINSLQEELLQLKAIHQEEVKELMCQIEASAKEHEAEINKLNELKENL 280 Query: 2297 QQQLKITTDN--KVIEEKNELIR------DLETQI-ECLMSDQECVKRNREEEIEQLNEV 2347 +Q + + N K E + E +R + + QI L+ + V++ E+++ L + Sbjct: 281 VKQCEASEKNIQKKYECELENLRKATSNANQDNQICSILLQENTFVEQVVNEKVKHLEDT 340 Query: 2348 IEKLQQE----------LANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETA 2397 +++L+ + + N+ K M+A + +E + L+ I E L +++ Sbjct: 341 LKELESQHSILKDEVTYMNNLKLKLEMDAQHIKDEFFHEREDLEFKINELLLAKEEQGCV 400 Query: 2398 NEEM-TFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPE 2456 E++ + + + K+ + + Q +E+ SLK + + ++I + E ++ +K + Sbjct: 401 IEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQ--KEISELNETFLS------DSEKEK 452 Query: 2457 LEVVLTEDALKSLENQTYFKSFEENGKGSIINLET-----RLLQLESTVSAKDLELTQCY 2511 L ++ LK ++ ++ + +I+N E+ +LQ E SA + Sbjct: 453 LTLMFEIQGLKE-----QCENLQQEKQEAILNYESLREIMEILQTELGESAGKIS----- 502 Query: 2512 KQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLE---AVQEYAKFCQDNQT 2568 ++ + M++Q + LQ+K+ E+ V+++Q E + + + T Sbjct: 503 QEFESMKQQQASDVHELQQKLRTA--FTEKDALLETVNRLQGENEKLLSQQELVPELENT 560 Query: 2569 ISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNV 2628 I + E+ + L+ + D + ++ +I+ L + + L E+++ K Sbjct: 561 IKNLQEKNGVYLLSLSQRDTMLKELEG---KINSLTEEKDDFINKLKNSHEEMDNFHKKC 617 Query: 2629 LEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEE-SGFFNELEALR 2687 +E+ +LEL K +E + E E+K + + +T E ++++ +++ L Sbjct: 618 EREERLILELGKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLS 677 Query: 2688 AESVATKAELASYKEKAEKLQEEL--LVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKE 2745 + AE+ S E+ KL E L ++ + QK+ +++H+ + ++KL ++ +E Sbjct: 678 EDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQLMVEE 737 Query: 2746 DET--EVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSE 2803 + ++ E+++ + L +K +Q G LK S + K+ + E Sbjct: 738 QDNLNKLLENEQV---QKLFVK------TQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGE 788 Query: 2804 CSSEEVTEIISQFTEKIEKMQELHAAEILDMESRHISETETLK---REHYVAVQLLKEEC 2860 ++ E + ++ EK+ EL EI ++ + + E LK R++ LL++E Sbjct: 789 SLAKINEEKCNLAFQRDEKVLELEK-EIKCLQEESVVQCEELKSLLRDYEQEKVLLRKEL 847 Query: 2861 GTLKAVIQCLRS-----KEGSSIPELAHSDAY----QTREICSSDSGSDWGQGIYLTHSQ 2911 +++ + L+S K + L + + + + CS + + ++ + Sbjct: 848 EEIQSEKEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEKCFIKEHE 907 Query: 2912 GFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEP 2971 E + A K +V N+ + + E + E Sbjct: 908 NLKPLLEQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKELEEKIENLEKEC------- 960 Query: 2972 WLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVF--LEE 3029 +E++ IN I + K E + ES + +L +++ + E Sbjct: 961 --KEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEKDQLSASMRDLIQGAES 1018 Query: 3030 RSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQ-AAMECLQ-KADRRSLLSEIQ 3087 LL + + L N E RI++ + + + ++C +D LL+ I+ Sbjct: 1019 YKNLLLEYEKQSEQLDVEKERA--NNFEHRIEDLTRQLRNSTLQCETINSDNEDLLARIE 1076 Query: 3088 ALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLS 3147 L + ++ + Q ++ + LE QK+ ++ E ++ ++ ELQ QL Sbjct: 1077 TLQSNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNELE----ELQVQLQ 1132 Query: 3148 SEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQK 3207 EK +L +T ELE K ++ +E+ D + LN L ++ Sbjct: 1133 KEK-------KQLQKTMQELELV----KKDAQQTTLMNMEIADYERLMKELNQKLTNKNN 1181 Query: 3208 KSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQ 3267 K +L+ ++ +K K +E +EE+ L+ S++ +++N ++ LL + K+ L +S+Q Sbjct: 1182 KIEDLEQEIKIQKQK----QETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQ 1237 Query: 3268 KIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQS 3327 E+ ++ A L E + Q +E K+++ E++S + ++H L++S Q Sbjct: 1238 A-ETDHLILQASLKGELEAS---QQQVEVYKIQLAEITS---EKHKIHEHLKTSAEQHQ- 1289 Query: 3328 RPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQ 3387 R + + LQ++ + + +E E YK+ +Q +K++ + + + + Sbjct: 1290 RTLSAYQQRVTALQEECRAAKAEQATVTSEFESYKVRVHNVLKQ-QKNKSMSQAETEGAK 1348 Query: 3388 EANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEG----QRLQGIMQEFQKQELERE 3443 + + + +L+ K++D Q L+ ++ L E +R ++QE +E E Sbjct: 1349 QEREHLEMLIDQLKIKLQDSQNNLQINVSELQTLQSEHDTLLERHNKMLQETVSKEAELR 1408 Query: 3444 EKR---ESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETK--ESNYAKLIEMNGGGT 3498 EK +S ++ ++ + T LTS +N VL+ + + + + K +E Sbjct: 1409 EKLCSIQSENMMMKSEHTQTVSQLTS---QNEVLRNSFRDQVRHLQEEHRKTVET----- 1460 Query: 3499 GCNHELEMIRQKLQCVASKLQVLPQKASERLQFETADDEDFIWVQENIDEIILQLQKLTG 3558 ++Q+L + ++L L + + R + + + N D +L + +T Sbjct: 1461 --------LQQQLSKMEAQLFQLKNEPTTRSPVSSQQSLKNLRERRNTDLPLLDMHTVTR 1512 Query: 3559 QQGE------EPSLVSPSTSCGSLTERL 3580 ++GE S+ S ST SL + L Sbjct: 1513 EEGEGMETTDTESVSSASTYTQSLEQLL 1540 Score = 154 bits (389), Expect = 2e-36 Identities = 307/1513 (20%), Positives = 630/1513 (41%), Gaps = 233/1513 (15%) Query: 1507 DVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIH 1566 ++K K+E + ++G+ KE+ S+ + E+ L +S+DK + +Q Sbjct: 99 NIKMKQEVEDSVTKMGDAHKELEQSHINYVKEIENLKNELMAVRSKYSEDKANLQKQL-- 156 Query: 1567 DEISVSSMDASRQLML---NEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQ 1623 +E + ++ S QL +E+ ++ +++E+ + ++ L++ + ++E Sbjct: 157 EEAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQKQLDATTDEKKETV 216 Query: 1624 EQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSST 1683 QLQ I+ N Q Q+ N+ S L EEL LK + ++L C++ S+ Sbjct: 217 TQLQNIIEA-NSQHYQK------NINS-----LQEELLQLKAIHQEEVKELMCQIEASAK 264 Query: 1684 QTQNGNENQGEVEEQTFKEKELDRKPEDVPPEI-LSNERYALQKAN--NRLLKILLEVVK 1740 + + E++E K+ E K E L N R A AN N++ ILL+ Sbjct: 265 EHEAEINKLNELKENLVKQCEASEKNIQKKYECELENLRKATSNANQDNQICSILLQ--- 321 Query: 1741 TTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEA--SVKSCVHEEHTRVTDESIPSY 1798 VE+ + V + D + +S S++ + E ++K + + + DE Sbjct: 322 ENTFVEQVVNEKVKHLEDTLKELESQHSIL-KDEVTYMNNLKLKLEMDAQHIKDEFFHER 380 Query: 1799 SGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTE------IDPENEELMLNISSRLQA 1852 + N++ + + E+G + + ++S AG ++ N E+ ++ + Q Sbjct: 381 EDLEFKINELLLAKE--EQGCVIEK--LKSELAGLNKQFCYTVEQHNREVQ-SLKEQHQK 435 Query: 1853 AVEKLLEAISETSSQLEHAKVTQTELMRESFRQ-KQEATESLKCQEELRERLHEESRARE 1911 + +L E S + + + + + ++E +QE E++ E LRE + E Sbjct: 436 EISELNETFLSDSEKEKLTLMFEIQGLKEQCENLQQEKQEAILNYESLREIM-------E 488 Query: 1912 QLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQE 1971 L EL ++ G I FE Q++ + L+Q+L A L ++Q Sbjct: 489 ILQTELGESAGKISQE------FESMKQQQASDVHELQQKLRTAFTEKDALLETVNRLQG 542 Query: 1972 ERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVE 2031 E E L Q+E + L+ T K ++EK V + RD + K+++ Sbjct: 543 ENEKLLSQQELVPE---------LENTIKNLQEKNGVYLLSLSQRDTMLKELEG------ 587 Query: 2032 EQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLE 2091 + L +EK+ + L+ ++ E D F ++ ++ E Sbjct: 588 ----KINSLTEEKDDFINKLKNSHE----------------------EMDNFHKKCEREE 621 Query: 2092 QQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEF 2151 + + + + +VEQ + E K +EL E+ ++ + ++++EKL Sbjct: 622 RLILELGK----------KVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMV 671 Query: 2152 RVREL---------EQALLVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEE 2202 +++ L E L E+ + + + LEV L + D I ++ IT LE+ Sbjct: 672 QMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVI--LKEHITQLEK 729 Query: 2203 QLEQFREELEN-----KNEEVQQLHMQLEIQ--KKESTTRLQELEQENKLFKDDMEKLGL 2255 +L+ EE +N +NE+VQ+L ++ ++ KE + + E +E D+ + Sbjct: 730 KLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEK-----DVVNVLQ 784 Query: 2256 AIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNE----QVTKLQQQLKITTDNKVIEE 2311 A+ ES A +++ L + + + E E EI L E Q +L+ L+ KV+ Sbjct: 785 AVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEKVLLR 844 Query: 2312 KNELIRDLETQIECLMSD-QECVKRNREEEIEQLNEVI--EKLQQ-----ELANIGQKTS 2363 K + +++++ E L SD E N + +E N +I E++ Q E+ N +K Sbjct: 845 KE--LEEIQSEKEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEKCF 902 Query: 2364 MNAHSLSE---EADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNV----------LKE 2410 + H + E L+ + +I K +L + N+ ++ +K + KE Sbjct: 903 IKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKELEEKIENLEKECKE 962 Query: 2411 TNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLE 2470 K+N++ K+E +S K +V ++ L +K +L + D ++ E Sbjct: 963 KEEKINKIKLVAVKAKKELDSSRK----ETQTVKEELESLRSEKDQLSASM-RDLIQGAE 1017 Query: 2471 NQ-----TYFKSFEENG--KGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQF 2523 + Y K E+ K N E R+ L + L+ +D+ + Sbjct: 1018 SYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETINSDNEDL--LARI 1075 Query: 2524 ETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPE--------- 2574 ET K++ +Q + ++ A + +++ E +Q+ K + T++ E Sbjct: 1076 ETLQSNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNELEELQVQLQKEK 1135 Query: 2575 ---RTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEK 2631 + +Q L +++D + + + I++ E + E++ L + ++E E+ + + Sbjct: 1136 KQLQKTMQELELVKKD--AQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQEIKIQ 1193 Query: 2632 EKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNE--------ESGFFNEL 2683 ++K LQ+ + + ++ E+K + ++KT EL S + ++ EL Sbjct: 1194 KQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQAETDHLILQASLKGEL 1253 Query: 2684 EALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILE 2743 EA + + K +LA + K+ E L +T+ Q+ LS + + +E+ + Sbjct: 1254 EASQQQVEVYKIQLAEITSEKHKIHEHL---KTSAEQHQRTLSAYQQRVTALQEECRAAK 1310 Query: 2744 KEDETEVQ--ESKKACMFEPLPIKLSKSIA-SQTDGT-------------LKISSSNQTP 2787 E T ES K + L + +KS++ ++T+G LKI + Sbjct: 1311 AEQATVTSEFESYKVRVHNVLKQQKNKSMSQAETEGAKQEREHLEMLIDQLKIKLQDSQN 1370 Query: 2788 QILVKNAGIQINLQSECS------SEEVTEIISQFTEKIEKMQELHAAEILDMESRH--- 2838 + + + +Q LQSE ++ + E +S+ E EK+ + + ++ M+S H Sbjct: 1371 NLQINVSELQ-TLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSENMM-MKSEHTQT 1428 Query: 2839 ----ISETETLK-----------REHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAH 2883 S+ E L+ EH V+ L+++ ++A + L+++ + P + Sbjct: 1429 VSQLTSQNEVLRNSFRDQVRHLQEEHRKTVETLQQQLSKMEAQLFQLKNEPTTRSPVSSQ 1488 Query: 2884 SDAYQTREICSSD 2896 RE ++D Sbjct: 1489 QSLKNLRERRNTD 1501 Score = 147 bits (371), Expect = 2e-34 Identities = 285/1401 (20%), Positives = 571/1401 (40%), Gaps = 256/1401 (18%) Query: 134 LREEEFGVDDSYSEQGAQDSPTHLEMMESELA---------GKQHEIEELNRELEEMRVT 184 L+ E V YSE A E M ++L + +++L E+E++R Sbjct: 134 LKNELMAVRSKYSEDKANLQKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPG 193 Query: 185 YGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQIQFQQ 244 + + L ++ +A ++ +TQL N+ +A SQ Q Sbjct: 194 FEEQILYLQKQLDATTDEKKETVTQL-QNIIEA----------------NSQHYQKNINS 236 Query: 245 LQASETLRNSTHSSTAADLL-QAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQE 303 LQ + H +L+ Q + H+ ++ + + L E+ K+ E I Sbjct: 237 LQEELLQLKAIHQEEVKELMCQIEASAKEHEAEINKLNELKENLVKQCEASEKNIQ---- 292 Query: 304 KIKVYEMEQD---KKVENSNKEE-----IQEKETIIEELNTKIIEEEKKTLELKDKLTTA 355 K YE E + K N+N++ + ++ T +E+ ++ E+ K LE D L Sbjct: 293 --KKYECELENLRKATSNANQDNQICSILLQENTFVEQ----VVNEKVKHLE--DTLKEL 344 Query: 356 DKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFE 415 + L++++ N N+KL+L ++ IK E +R +D +F+ Sbjct: 345 ESQHSILKDEVTYMN----NLKLKL-------EMDAQHIKD-----EFFHER--EDLEFK 386 Query: 416 TDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENAL 475 + + ++E +E+L++EL + Q + QH +++ +K +H+ E+ Sbjct: 387 INELLLAKEEQGCVIEKLKSELAGLNKQFCY-----TVEQHNREVQSLKEQHQKEISELN 441 Query: 476 RSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVE 535 ++ + + ++++ LM ++Q Q E L++E + +L+ +E L Sbjct: 442 ETFLSDS-EKEKLTLM--------FEIQGLKEQCENLQQEKQEAILNYESLREIMEILQT 492 Query: 536 ELSFSREQIQRARQTIAEQES----KLNEAHKSLSTVEDLKAEIVSASESRKELELKHEA 591 EL S +I + +++ +Q++ +L + ++ T +D E V+ + E L + Sbjct: 493 ELGESAGKISQEFESMKQQQASDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQE 552 Query: 592 EVTNYKIKLEMLEKEKNAVL-------DRMAESQEAELERLRTQ------LLFSHEEELS 638 V + ++ L+ EKN V D M + E ++ L + L + EE+ Sbjct: 553 LVPELENTIKNLQ-EKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEEMD 611 Query: 639 KLKEDLEIEHRINIE-KLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLIL 697 + E E R+ +E K I Y +++ NE++ +E EKD K +L++ Sbjct: 612 NFHKKCEREERLILELGKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMV 671 Query: 698 EISKL-----------------------------KDLQQSLVNSKSEEMTLQINELQKEI 728 ++ L +DL+ L + + I +L+K++ Sbjct: 672 QMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKL 731 Query: 729 EILRQEEKEKGTL--EQEVQELQLKTEL---LEKQMKEKENDLQEK------------FA 771 +++ +E+ L ++VQ+L +KT+L L++ E D +EK A Sbjct: 732 QLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGESLA 791 Query: 772 QLEAE--NSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWE-----KEIEI 824 ++ E N + ++K LE L+ QEE ++ + +KS +D E KE+E Sbjct: 792 KINEEKCNLAFQRDEKVLE--LEKEIKCLQEESVVQCEELKSLLRDYEQEKVLLRKELEE 849 Query: 825 LIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNK 884 + E E L+ +++ EK R +N + +E+ + + K ++ + K K Sbjct: 850 IQSEKEALQSDLLEMKNANEKTR----LENQNLLIQVEEVSQTCS-----KSEIHNEKEK 900 Query: 885 QELEYKSKLKALNEELHLQRINPTTVKMKS------SVFDEDKTFVAETLEMGEVVEKDT 938 ++ LK L E+ L+ + +K SV ++ + V E E E +EK+ Sbjct: 901 CFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKELEEKIENLEKEC 960 Query: 939 TELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCREL- 997 E EK+ K ++ ++L E + EE++SL+ EK+Q+S R+L Sbjct: 961 KEKEEKINKIKLVAVK-------AKKELDSSRKETQTVKEELESLRSEKDQLSASMRDLI 1013 Query: 998 ------------------EIIINHNRAENVQ---------------SCDTQVSSLLDGVV 1024 ++ + RA N + C+T S D + Sbjct: 1014 QGAESYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETINSDNEDLLA 1073 Query: 1025 TMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSL 1084 + + + + +V + +K MV+ ++ E + ++EQ I +H +V + L Sbjct: 1074 RIETLQSNAKLLEVQILEVQRAKAMVDKELEAEKL------QKEQKIKEHATTVNELEEL 1127 Query: 1085 RATQPSENDKLQKELN----VLKSEQNDLRLQMEA---QRICLSLVY-----STHVDQVR 1132 + E +LQK + V K Q + ME +R+ L + ++ + Sbjct: 1128 QVQLQKEKKQLQKTMQELELVKKDAQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLE 1187 Query: 1133 EYMENEKDKALCSLKEELIFAQ---EEKIKELQKIHQLELQTMKTQETGDEGKPLHLLI- 1188 + ++ +K K +L+EE+ Q ++ ++ KI QL ++T K + + HL++ Sbjct: 1188 QEIKIQKQKQE-TLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQAETDHLILQ 1246 Query: 1189 ----GKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQD 1244 G+L+ + + Y +Q L + E + + +AE + + L Sbjct: 1247 ASLKGELEASQQQVEVYKIQ-LAEITSEKHKIHEHLKTSAEQHQRT-----------LSA 1294 Query: 1245 YRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEF 1304 Y+ V QE + ++ + R+ + QQ + + E K+E E Sbjct: 1295 YQQRVTALQEECRAAKAEQATVTSEFESYKVRVHNVLKQQKN-KSMSQAETEGAKQEREH 1353 Query: 1305 LS--IHSQMTNLEDIDVNHKSKLSSLQDLEK---TKLEEQVQELESLISSLQQQLKETEQ 1359 L I L+D N + +S LQ L+ T LE + L+ +S + +L+E Sbjct: 1354 LEMLIDQLKIKLQDSQNNLQINVSELQTLQSEHDTLLERHNKMLQETVSK-EAELREKLC 1412 Query: 1360 NYEAEIHCLQ-KRLQAVSEST 1379 + ++E ++ + Q VS+ T Sbjct: 1413 SIQSENMMMKSEHTQTVSQLT 1433 Score = 145 bits (365), Expect = 1e-33 Identities = 328/1609 (20%), Positives = 682/1609 (42%), Gaps = 222/1609 (13%) Query: 2171 VEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREE--LENKNEEVQQLHMQLE-- 2226 +E P+ L + + I + + T LE+++E+ R + E + ++ L +L+ Sbjct: 22 LETLPKEDLIKFAKKQMMLIQKAKSRCTELEKEIEELRSKPVTEGTGDIIKALTERLDAL 81 Query: 2227 -IQKKESTTRLQELEQENKLFKDDME----KLGLAIKESDAMSTQDQHVLFGKFAQIIQE 2281 ++K E+ + L++EN K ++E K+G A KE + H+ + K Sbjct: 82 LLEKAETEQQCLSLKKENIKMKQEVEDSVTKMGDAHKE-----LEQSHINYVK------- 129 Query: 2282 KEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLE----TQIECLMSDQECVKRNR 2337 EI+ L ++ ++ +K E+K L + LE TQ+E +S+Q + N Sbjct: 130 ---EIENLKNELMAVR--------SKYSEDKANLQKQLEEAMNTQLE--LSEQLKFQNNS 176 Query: 2338 EEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETA 2397 E+ +++L E IEK++ E+ L+ QLD EK Q++ Sbjct: 177 EDNVKKLQEEIEKIRP--------------GFEEQILYLQKQLDATTDEKKETVTQLQNI 222 Query: 2398 NEEMT--FMKNVLKETNFKMNQLTQELFSLKR-ERESVEKIQSIPENSVNVAIDHLSKDK 2454 E + + KN+ N L +EL LK +E V+++ E S A +H Sbjct: 223 IEANSQHYQKNI--------NSLQEELLQLKAIHQEEVKELMCQIEAS---AKEH----- 266 Query: 2455 PELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQI 2514 E E+ + ++L Q E + K E L L S + + C Sbjct: 267 -EAEINKLNELKENLVKQC-----EASEKNIQKKYECELENLRKATSNANQDNQIC---- 316 Query: 2515 KDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYA-KFCQDNQTISSE- 2572 + ++ F +++ +K+ +L+ ++E + + + ++ + K D Q I E Sbjct: 317 SILLQENTFVEQVVNEKVKHLEDTLKELESQHSILKDEVTYMNNLKLKLEMDAQHIKDEF 376 Query: 2573 -PERTNIQ-NLNQL--REDELGSDISALTLRISELESQ---VVEMHT---SLILEKEQVE 2622 ER +++ +N+L ++E G I L ++ L Q VE H + E+ Q E Sbjct: 377 FHEREDLEFKINELLLAKEEQGCVIEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQKE 436 Query: 2623 IAEKNVL-----EKEKKLL--ELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSN- 2674 I+E N EKEK L E+Q L E E Q+EK++ + + E L+ E+ + Sbjct: 437 ISELNETFLSDSEKEKLTLMFEIQGLKEQCENLQQEKQE--AILNYESLREIMEILQTEL 494 Query: 2675 -EESGFFN-ELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHL 2732 E +G + E E+++ + + EL A ++ LL + + L ++ + Sbjct: 495 GESAGKISQEFESMKQQQASDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQELV 554 Query: 2733 AEAKEKLSILEKEDETEVQE-SKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILV 2791 E + + L++++ + S++ M + L K++ + D K+ +S++ Sbjct: 555 PELENTIKNLQEKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEEMDNFH 614 Query: 2792 KNAGIQINLQSECSSEEVTEIISQFTEKIEKMQELHAA--EILDMESRHISETETLKREH 2849 K + L E ++V + I +E +K+ EL E L + ++ + E L Sbjct: 615 KKCEREERLILELG-KKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLM--- 670 Query: 2850 YVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREICSSDSGSDWGQGIYLTH 2909 V +++L E+ L A ++ L Y+ SS+ + + + Sbjct: 671 -VQMKVLSEDKEVLSAEVKSL----------------YEENNKLSSEK-KQLSRDLEVFL 712 Query: 2910 SQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVS 2969 SQ D+ + + E ++ L + + NE +Q L + Y ++ +VS Sbjct: 713 SQKEDVILKEHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMG-SEVS 771 Query: 2970 EPWLEERKAYINTISSLKDLITKMQ-------LQREAEVYDSSQSHESFSDW---RGELL 3019 E E K +N + ++ + + K+ QR+ +V + + + + + E L Sbjct: 772 ED--SEEKDVVNVLQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEEL 829 Query: 3020 LALQQVFLEERSVL---LAAFRTELTALGTTDAVGLLNCLEQ-RIQEQGVEYQAAMECLQ 3075 +L + + +E+ +L L ++E AL +D + + N E+ R++ Q + Q E Q Sbjct: 830 KSLLRDYEQEKVLLRKELEEIQSEKEAL-QSDLLEMKNANEKTRLENQNLLIQVE-EVSQ 887 Query: 3076 KADRRSLLSEIQA--LHAQMNGRKITLKREQESEKPSQELLEYNIQQKQS-------QML 3126 + + +E + + N + + ++E + LL+ ++ + S + Sbjct: 888 TCSKSEIHNEKEKCFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKNDPLSSVK 947 Query: 3127 EMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRL 3186 E++ ++ +++ E +E+++ K+V + K EL ++ E +T + E + Sbjct: 948 ELEEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEKDQLSA 1007 Query: 3187 EVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQ 3246 ++D + L +K+S +L +EKE+A + +EDL L + Sbjct: 1008 SMRDLIQGAESYKNLLLEYEKQSEQLD--VEKERAN------NFEHRIEDLTRQLRNS-- 1057 Query: 3247 RNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKV----RIR 3302 LQ + + LL + ++S L + Q+ E Q + LE+EK+ +I+ Sbjct: 1058 -TLQCETINSDNEDLLARIET-LQSNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIK 1115 Query: 3303 EMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLE------EKHSRIVELLN 3356 E ++T++ EL QLQ Q + + +L+K+ +Q + R+++ LN Sbjct: 1116 EHATTVNELEELQVQLQKEKK--QLQKTMQELELVKKDAQQTTLMNMEIADYERLMKELN 1173 Query: 3357 ETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDL----QRQLE 3412 + K + ++ +Q K ++ ++TLQ E + ++ E +K++ L +++L Sbjct: 1174 QKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELA 1233 Query: 3413 EKRQQ-----VYKLDLEGQRLQGIMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSD 3467 + +Q + + L+G+ L+ Q+ + +++ E + ++++L T + Sbjct: 1234 DSKQAETDHLILQASLKGE-LEASQQQVEVYKIQLAEITSEKHKIHEHLK---TSAEQHQ 1289 Query: 3468 RTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEM---IRQKLQCVASKLQVLPQK 3524 RT + QQ++ +E AK + ++++ + ++Q+ S+ + K Sbjct: 1290 RTLS-AYQQRVTALQEECRAAKAEQATVTSEFESYKVRVHNVLKQQKNKSMSQAETEGAK 1348 Query: 3525 ASERLQFETADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQN 3584 ER E D+ I +Q++ + + + + +L Q E +L+ + + + + Sbjct: 1349 -QEREHLEMLIDQLKIKLQDSQNNLQINVSELQTLQSEHDTLLERHNK---MLQETVSKE 1404 Query: 3585 AELTGHISQLTEEKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRFSLNGGANIEAIIASEK 3644 AEL + + E NM+MK E + QT + + + N + + + Sbjct: 1405 AELREKLCSIQSE-----NMMMKSE-----HTQTVSQLTSQNEVLRN---SFRDQVRHLQ 1451 Query: 3645 EVWNREKLTLQKSLKRAEAEVYKLKAELRNDSLLQTLSPDSEHVTLKRI 3693 E + TLQ+ L + EA++++LK E T SP S +LK + Sbjct: 1452 EEHRKTVETLQQQLSKMEAQLFQLKNE------PTTRSPVSSQQSLKNL 1494 Score = 37.4 bits (85), Expect = 0.29 Identities = 79/396 (19%), Positives = 163/396 (41%), Gaps = 63/396 (15%) Query: 3320 SSDGTGQSR-PPLPSEDLLKELQKQ---LEEKHSRIVELLNETEKYKLDSLQ------TR 3369 ++ GTG+S+ LP EDL+K +KQ +++ SR EL E E+ + + + Sbjct: 13 ATPGTGKSKLETLPKEDLIKFAKKQMMLIQKAKSRCTELEKEIEELRSKPVTEGTGDIIK 72 Query: 3370 QQMEKDRQVHRKTLQTEQEA------NTEGQKKMHELQSKVEDLQRQLEEKR-QQVYKLD 3422 E+ + + +TEQ+ N + ++++ + +K+ D ++LE+ V +++ Sbjct: 73 ALTERLDALLLEKAETEQQCLSLKKENIKMKQEVEDSVTKMGDAHKELEQSHINYVKEIE 132 Query: 3423 LEGQRLQGIMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGET 3482 L + ++ + + +++ E L+E Q K + + Sbjct: 133 NLKNELMAVRSKYSEDKANLQKQLEEAMNTQLELSE----------------QLKFQNNS 176 Query: 3483 KESNYAKLIEMNGGGTGCNHELEMIR----QKLQCVASKLQVLPQKASERL-QFETADDE 3537 E N KL E E+E IR +++ + +L + E + Q + + Sbjct: 177 -EDNVKKLQE----------EIEKIRPGFEEQILYLQKQLDATTDEKKETVTQLQNIIEA 225 Query: 3538 DFIWVQENIDEIILQLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEE 3597 + Q+NI+ + +L +L EE L ++ E I++L E Sbjct: 226 NSQHYQKNINSLQEELLQLKAIHQEEVK---------ELMCQIEASAKEHEAEINKLNEL 276 Query: 3598 KNDLRNMVMKLEEQIRWYRQTGAGRDNSSRFSLNGGANIEAIIASE----KEVWNREKLT 3653 K +L E+ I+ + + + N I +I+ E ++V N + Sbjct: 277 KENLVKQCEASEKNIQKKYECELENLRKATSNANQDNQICSILLQENTFVEQVVNEKVKH 336 Query: 3654 LQKSLKRAEAEVYKLKAELR-NDSLLQTLSPDSEHV 3688 L+ +LK E++ LK E+ ++L L D++H+ Sbjct: 337 LEDTLKELESQHSILKDEVTYMNNLKLKLEMDAQHI 372 >gi|153791497 ciliary rootlet coiled-coil [Homo sapiens] Length = 2017 Score = 176 bits (447), Expect = 3e-43 Identities = 422/2045 (20%), Positives = 793/2045 (38%), Gaps = 320/2045 (15%) Query: 1592 QELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSIDNE----- 1646 +E+V + ++ LL M + +E+ + LQ+E+ R+ LAQ + +E Sbjct: 52 REIVTRNLSQPESPVLLPATEMASLLSLQEENQLLQQELSRVEDLLAQSRAERDELAIKY 111 Query: 1647 NLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNENQG-EVEEQTFKEKEL 1705 N VSER LE+ L+ L TQ G Q E+ Q +E+ Sbjct: 112 NAVSER----LEQALRLEPGEL-------------ETQEPRGLVRQSVELRRQLQEEQAS 154 Query: 1706 DRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQS 1765 R+ E + +Q+ ++L+ + + E G L + SQ Sbjct: 155 YRRKLQAYQEGQQRQAQLVQRLQGKILQYKKRCSELEQQLLERSGELEQQRLRDTEHSQD 214 Query: 1766 SASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRL 1825 S + R E E + + + + + ++ + S + DI KVT + T + L Sbjct: 215 LESALIRLEEEQQRSASLAQVNAMLREQLDQAGSANQALSEDIR---KVTNDWTRCRKEL 271 Query: 1826 VRSGFAGTEIDPENEELMLNISSRLQAAVEKLL---EAISETSSQLEHAKVTQTELMRES 1882 A + N SRL +++ +SE E + + + Sbjct: 272 EHREAAWRREEESFNAYFSNEHSRLLLLWRQVVGFRRLVSEVKMFTERDLLQLGGELART 331 Query: 1883 FRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQ--- 1939 R QEA L L E E+ +Q ++ E + D EK L ++Q+Q Sbjct: 332 SRAVQEAGLGLSTGLRLAES-RAEAALEKQALLQAQLEEQLRDKVLREKDLAQQQMQSDL 390 Query: 1940 EKTDIIDRLEQELLCASNRLQELEAEQQQIQEE--------RELLSRQKEAMKAEAGPVE 1991 +K D+ R+ EL A RL++ E+ Q+ ++ L +++ A++ E G Sbjct: 391 DKADLSARVT-ELGLAVKRLEKQNLEKDQVNKDLTEKLEALESLRLQEQAALETEDGEGL 449 Query: 1992 QQLLQETEKLMKEKLEVQCQ---AEKVRDDLQKQVKALE--------------------- 2027 QQ L++ + + E Q +E+ D ++ L Sbjct: 450 QQTLRDLAQAVLSDSESGVQLSGSERTADASNGSLRGLSGQRTPSPPRRSSPGRGRSPRR 509 Query: 2028 -----IDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDV 2082 ++ ++ ++ D+R + +A + L +RK Q D E ER Sbjct: 510 GPSPACSDSSTLALIHSALHKRQLQVQDMRGRYEASQDLLGTLRK----QLSDSESERRA 565 Query: 2083 FQQEIQKL-----------EQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLS 2131 ++++Q+L E + V R + +E +RE LA+ L+ + EL Sbjct: 566 LEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQE 625 Query: 2132 KEQLQRDIQERNEEIEKLEFRVRELEQALLVEDRKHFGAVEAKPELSLEVQLQAERDAID 2191 +E+LQ +E + ++LE EQ V+D + LE QL+ +R + Sbjct: 626 REKLQAAQEELRRQRDRLEE-----EQEDAVQDGARVRRELERSHRQLE-QLEGKRSVLA 679 Query: 2192 RKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDME 2251 ++ E+ + R+ L+ + EV + + E + E + +L E +D + Sbjct: 680 KELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQDSLS 739 Query: 2252 KLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEE 2311 KL A+ ES A D LN V +L EE Sbjct: 740 KLS-ALNESLAQDKLD---------------------LNRLVAQL-------------EE 764 Query: 2312 KNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSE 2371 + ++ + Q E + V R +E +E+L +L+QE+A G + S+ ++ Sbjct: 765 EKSALQGRQRQAE----QEATVAREEQERLEEL-----RLEQEVARQGLEGSLRVAEQAQ 815 Query: 2372 EADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERE- 2430 EA LEQQ+ T E + ++ L + + +++ QEL +RE + Sbjct: 816 EA----------------LEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQR 859 Query: 2431 SVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSL-ENQTYFKSFEENGKGSIINL 2489 VE ++ +A +H +++V E ++L E T + +E +GS+ + Sbjct: 860 QVEALERAAREKEALAKEHAGL---AVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEV 916 Query: 2490 ETRLLQLEST-----------VSAKDL---ELTQCYKQIKDMQEQGQFETEMLQKKIV-- 2533 + +L QLE+ + AK+ EL +QI QE+ + E++ +K+V Sbjct: 917 QRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQA 976 Query: 2534 -----------------NLQKIVEEKVAA---------ALVSQIQLEAVQEYAKFCQDNQ 2567 +LQ++ EK AA L SQ+Q E + A+ + + Sbjct: 977 EREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQEELLARLEAEKE 1036 Query: 2568 TISSEPERTNIQNLNQLREDEL----GSDISALTLRISE---LESQVVEMHTSLI---LE 2617 +S E I L Q R++ L AL+L+ SE L +++ SL LE Sbjct: 1037 ELSEE-----IAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISLE 1091 Query: 2618 KEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEES 2677 E+ + ++ E+++ + + + QRE+ Q+V L+ +S Sbjct: 1092 MERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDS 1151 Query: 2678 GFFNELEALRAE-------SVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQ--- 2727 E E LR + + EL + K + QE V+ L++ L + Sbjct: 1152 -CLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAGELRRSLGEGAK 1210 Query: 2728 VRDHLAEAKEKLSILEKEDETE--------VQESKKACMFEPLPIKLSKSIASQTDGTLK 2779 R+ L + E+L K+ E+E + +K + E + K G + Sbjct: 1211 EREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQE 1270 Query: 2780 ISSSNQTPQILVKNAGIQIN-LQSECS--SEEVTEIISQFT--EKIEKMQELHAAEILDM 2834 + S + ++ Q+ L SE + E+ E+ + E+ EK + Sbjct: 1271 VERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEKESRRETLGLRQR 1330 Query: 2835 ESRHISETETLKREHYVAVQLLKEECGTLKA----VIQCLRSKEGSSIPELAHSDAYQTR 2890 + + E +++E VA + L+E+ G + ++ L G+ +L H+ + + Sbjct: 1331 LLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHARGLELK 1390 Query: 2891 EICSSDSGSDWGQGIYLTHSQGFDIASEGR--GEESESATDSFPKKIK----GLLRAVHN 2944 + ++ G + A+EGR G E+E A ++ G LR+ Sbjct: 1391 LEAARAEAAELGLRLS---------AAEGRAQGLEAELARVEVQRRAAEAQLGGLRSALR 1441 Query: 2945 EGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINTISSLKDLITKMQLQREAEVYDS 3004 G L L +P + E +N+ S+L + Q Sbjct: 1442 RG---LGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTL-ECSPGSQPPSPGPATSP 1497 Query: 3005 SQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQG 3064 + RG L LQ++ +R RT+ +AL A + + Sbjct: 1498 ASPDLDPEAVRGALREFLQELRSAQRE--RDELRTQTSALNRQLAE--MEAERDSATSRA 1553 Query: 3065 VEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQE---LLEYNIQQK 3121 + Q A+ ++A RRS+ + + A++ ++ +++R + + + + LE ++Q Sbjct: 1554 RQLQKAVAESEEA-RRSVDGRLSGVQAELALQEESVRRSERERRATLDQVATLERSLQAT 1612 Query: 3122 QSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLE---LETTLKAQHKHL 3178 +S++ Q ++S MK T+L+ K V+ +S + +L+ LE L+ L Sbjct: 1613 ESELRASQEKISKMKANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGL 1672 Query: 3179 KELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEE-----RDK-- 3231 + EA ++D+ D L +A + K+ LQ +E+ L + EE RDK Sbjct: 1673 SDREAQAQALQDRVDS---LQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVR 1729 Query: 3232 ---EELEDLKFSLESQKQRNLQLNLLL---EQQKQLLNESQQKIESQRMLYDAQLSEEQG 3285 E L SL S + +NL L L E +Q+L Q+++++ R + Sbjct: 1730 GLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVL---QERLDAARQALSEARKQSSS 1786 Query: 3286 RNLELQVL------LESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKE 3339 ++Q L LE ++V E L + RE+ Q Q + L + L++ Sbjct: 1787 LGEQVQTLRGEVADLELQRV---EAEGQLQQLREVLRQRQEGEAAA-----LNTVQKLQD 1838 Query: 3340 LQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHE 3399 ++ L+E+ + L + E K + ++ ++EKDR R+TL + + Sbjct: 1839 ERRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVALRRTLDKVEREKLRSHEDTVR 1898 Query: 3400 LQS--------------KVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELEREEK 3445 L + ++ + QRQ+++ QV L+ Q + + Q+Q+LE +++ Sbjct: 1899 LSAEKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQSHSPAQ-LEVDAQQQQLELQQE 1957 Query: 3446 RESRR 3450 E R Sbjct: 1958 VERLR 1962 Score = 162 bits (410), Expect = 6e-39 Identities = 402/1840 (21%), Positives = 753/1840 (40%), Gaps = 237/1840 (12%) Query: 1569 ISVSSMDASRQLMLNEEQLEDM--RQELVRQYQEHQQATELLRQAHMRQMERQRE-DQEQ 1625 + + + S L L E + E +Q L++ E Q ++LR+ + Q + Q + D+ Sbjct: 335 VQEAGLGLSTGLRLAESRAEAALEKQALLQAQLEEQLRDKVLREKDLAQQQMQSDLDKAD 394 Query: 1626 LQEEIKRLNRQLAQRSSIDNENLVSER-ERVLLEELEALKQLSLAGREKLCCELRNSSTQ 1684 L + L + + ++ +NL ++ + L E+LEAL+ L L + L E Sbjct: 395 LSARVTELGLAVKR---LEKQNLEKDQVNKDLTEKLEALESLRLQEQAALETE------- 444 Query: 1685 TQNGNENQGEVEEQTFKE-KELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTA 1743 GE +QT ++ + + ++ +ER A A+N L+ L + Sbjct: 445 -------DGEGLQQTLRDLAQAVLSDSESGVQLSGSERTA--DASNGSLRGLSGQRTPSP 495 Query: 1744 AVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDM 1803 + GR G R S + + S A + S +H+ +V D + D+ Sbjct: 496 PRRSSPGR---GRSPRRGPSPACSD----SSTLALIHSALHKRQLQVQDMRGRYEASQDL 548 Query: 1804 PRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISE 1863 S E L ++L R +E+ + RL++A E L S Sbjct: 549 LGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQ-RLRSANELLSREKSN 607 Query: 1864 TSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGV 1923 + L+ A+ Q E +R+ + Q A E L+ Q R+RL EE + V Sbjct: 608 LAHSLQVAQ-QQAEELRQEREKLQAAQEELRRQ---RDRLEEEQE------------DAV 651 Query: 1924 IDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQK--- 1980 DG R+++ +++LE + + L E+ + +R++L +K Sbjct: 652 QDG-----ARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEV 706 Query: 1981 -EAM-KAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFI 2038 EA+ KAEAG VE +L KL E+ +Q K+ L + + ++D+ V+ Sbjct: 707 AEALTKAEAGRVELEL--SMTKLRAEEASLQDSLSKL-SALNESLAQDKLDLNRLVA--- 760 Query: 2039 ELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVP 2098 +LE+EK+ RQ Q E+ + L+E +++E R Q LE L+V Sbjct: 761 QLEEEKSALQGRQRQAEQEATVAREEQER-LEELRLEQEVAR-------QGLEGSLRVAE 812 Query: 2099 RFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQ-LQRDIQERNEEIEKLEFRVRELE 2157 + Q E Q + + L+E+ + S L +EQ L++ +E ++E LE RE E Sbjct: 813 QAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKE 872 Query: 2158 QALLVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEE 2217 AK L VQL A +R+ + ++ +L +E LE E Sbjct: 873 AL-------------AKEHAGLAVQLVAA----EREGRTLSEEATRLRLEKEALEGSLFE 915 Query: 2218 VQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQ 2277 VQ+ QLE ++++ Q L + ++ L I + ++ D+ ++ K Q Sbjct: 916 VQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQ 975 Query: 2278 IIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNR 2337 +E + L EQ ++ L+ ++ EK R+LE + L S ++R + Sbjct: 976 AEREAQAS---LREQRAAHEEDLQ-----RLQREKEAAWRELEAERAQLQSQ---LQREQ 1024 Query: 2338 EEEIEQLNEVIEKLQQELANIGQKTS---MNAHSLSEEADSLKHQLDVVIAEKL-ALEQQ 2393 EE + +L E+L +E+A + Q+ + A S ++A SLK ++EKL Sbjct: 1025 EELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHS 1084 Query: 2394 VETANEEMTFMKNVLK----ETNFKMNQLTQELFSLKRERESV-----EKIQSIPENSVN 2444 + T + EM K + + +N LT EL L+ +RE ++++ + E + + Sbjct: 1085 LATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARD 1144 Query: 2445 VAI--DHLSKDKPEL--EVVLTEDALKSLENQTYF--KSFEENGKG-SIINLETRLLQLE 2497 + D ++ EL ++ L EDA L + + E+ +G + E L+ Sbjct: 1145 LGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAGELRRS 1204 Query: 2498 STVSAKDLE-LTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAV 2556 AK+ E L + ++++ ++ E+E + K+ N K E+K+A + EA Sbjct: 1205 LGEGAKEREALRRSNEELRSAVKKA--ESERISLKLANEDK--EQKLA------LLEEAR 1254 Query: 2557 QEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLIL 2616 K + +T E ER+ ++ +L+E L + L + L ++ E+ L L Sbjct: 1255 TAVGKEAGELRTGLQEVERSRLEARRELQE--LRRQMKMLDSENTRLGRELAELQGRLAL 1312 Query: 2617 EKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEE 2676 + + + + L ++LL+ + LE ++ + ++K Q+ E L S EE Sbjct: 1313 GERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEE 1372 Query: 2677 S------------GFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKD 2724 + G +LEA RAE+ L++ + +A+ L+ EL E + + Sbjct: 1373 ARGTEKQQLDHARGLELKLEAARAEAAELGLRLSAAEGRAQGLEAELARVEVQRRAAEAQ 1432 Query: 2725 LSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLSKSIASQTDG-------- 2776 L +R L + L + +A P P+ S + + +G Sbjct: 1433 LGGLRSAL---RRGLGL------------GRAPSPAPRPVPGSPARDAPAEGSGEGLNSP 1477 Query: 2777 -TLKISSSNQTPQILVKNAGIQINLQSECSSEEVTEIISQFTEKIEKMQELHA------A 2829 TL+ S +Q P + +L E + E + + + EL Sbjct: 1478 STLECSPGSQPPSPGPATSPASPDLDPEAVRGALREFLQELRSAQRERDELRTQTSALNR 1537 Query: 2830 EILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQT 2889 ++ +ME+ S T + R+ AV +E ++ + ++++ + S+ + Sbjct: 1538 QLAEMEAERDSAT-SRARQLQKAVAESEEARRSVDGRLSGVQAELALQEESVRRSERERR 1596 Query: 2890 REICSSDSGSDWGQGIYLTHSQGFDIASE--GRGEESESATDSFPKKIKGLLRAVHNEGM 2947 + D + + + T S+ + E + + +E+ + +++K +L A +E Sbjct: 1597 ATL---DQVATLERSLQATESE-LRASQEKISKMKANETKLEGDKRRLKEVLDA--SESR 1650 Query: 2948 QVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQS 3007 V + +GE Q S L +R+A +L+D + +Q Q V DS Sbjct: 1651 TVKLELQRRSLEGE----LQRSRLGLSDREA---QAQALQDRVDSLQRQ----VADS--- 1696 Query: 3008 HESFSDWRGELLLALQQVFLEERSVLLAAFRTELTAL-----GTTDAVGLLNCLEQRIQE 3062 E+ Q+ +E + LA AL G T+A+ + ++ Sbjct: 1697 ---------EVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTRD 1747 Query: 3063 QGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQ-ELLEYNIQQK 3121 + + Q A+ + DR+ L + A + ++ R+Q S Q + L + Sbjct: 1748 KNLHLQKALTACEH-DRQVLQERLDAAR-----QALSEARKQSSSLGEQVQTLRGEVADL 1801 Query: 3122 QSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSE--LAQTKL-ELETTLKAQHKHL 3178 + Q +E + +L +++ + QE ++ V +L+ E L Q +L L+ L Sbjct: 1802 ELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQRALAQLEAEK 1861 Query: 3179 KELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRS---EERDKEELE 3235 +E+E L ++ + D + E+ +S E L EK +L R+ E + E + Sbjct: 1862 REVERSALRLEKDRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQ 1921 Query: 3236 DLKFSLESQ----KQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQ 3291 LE+Q +Q + L ++ Q+Q L E QQ++E R AQ E R LE + Sbjct: 1922 RQIQQLEAQVVVLEQSHSPAQLEVDAQQQQL-ELQQEVERLR---SAQAQTE--RTLEAR 1975 Query: 3292 VLLESEKVR-IREMSSTLDRERELHAQLQSSDGTGQSRPP 3330 ++VR + E STL + + + S+ + S PP Sbjct: 1976 ERAHRQRVRGLEEQVSTLKGQLQQELRRSSAPFSPPSGPP 2015 Score = 133 bits (334), Expect = 4e-30 Identities = 405/2077 (19%), Positives = 829/2077 (39%), Gaps = 307/2077 (14%) Query: 439 EMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINEL 498 EM +Q + +L++Q ++++E++ + + E + Y+ ++ +Q L Sbjct: 72 EMASLLSLQEENQLLQQELSRVEDLLAQSRAERDELAIKYNAVSERLEQA---------L 122 Query: 499 NIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSR------EQIQRARQTIA 552 ++ + +Q+ + GL+ + L+RQL++ E+ S+ R E QR Q + Sbjct: 123 RLEPGELETQEPR-----GLV-RQSVELRRQLQE--EQASYRRKLQAYQEGQQRQAQLVQ 174 Query: 553 EQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLD 612 + K+ + K S +E E E ++ + +H ++ + I+LE E++++A L Sbjct: 175 RLQGKILQYKKRCSELEQQLLERSGELEQQRLRDTEHSQDLESALIRLEE-EQQRSASLA 233 Query: 613 RMAESQEAELERLRT--QLLFSHEEELSKLKEDL-----EIEHRINI-EKLKDNLGIHYK 664 ++ +L++ + Q L E++ K+ D E+EHR + +++ ++ Sbjct: 234 QVNAMLREQLDQAGSANQAL---SEDIRKVTNDWTRCRKELEHREAAWRREEESFNAYFS 290 Query: 665 ----------QQIDGLQNEMSQKIETMQFEKDNLITKQNQLI----------LEISKLKD 704 +Q+ G + +S E F + +L+ +L L +S Sbjct: 291 NEHSRLLLLWRQVVGFRRLVS---EVKMFTERDLLQLGGELARTSRAVQEAGLGLSTGLR 347 Query: 705 LQQSLVNSKSEEMTLQINELQKEI--EILR---------QEEKEKGTLEQEVQELQLKTE 753 L +S + E+ L +L++++ ++LR Q + +K L V EL L + Sbjct: 348 LAESRAEAALEKQALLQAQLEEQLRDKVLREKDLAQQQMQSDLDKADLSARVTELGLAVK 407 Query: 754 LLEKQMKEKE---NDLQEKFAQLEA----ENSILKDE-----KKTLEDMLKIHTPVSQEE 801 LEKQ EK+ DL EK LE+ E + L+ E ++TL D+ + +S E Sbjct: 408 RLEKQNLEKDQVNKDLTEKLEALESLRLQEQAALETEDGEGLQQTLRDLAQ--AVLSDSE 465 Query: 802 RLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQR-------NTFSFAE 854 + L + + S + L + + +R ++ + A Sbjct: 466 SGVQLSGSERTADAS--NGSLRGLSGQRTPSPPRRSSPGRGRSPRRGPSPACSDSSTLAL 523 Query: 855 KNFEVNYQELQ-EEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMK 913 + ++ ++LQ ++ + DL + KQ + +S+ +AL E+ LQR+ T Sbjct: 524 IHSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQ--LQRLRDKTDGAM 581 Query: 914 SSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEI 973 + D + V E++ ++ + L L+V +++ EL Q L ++ + Sbjct: 582 QAHEDAQRE-VQRLRSANELLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQR 640 Query: 974 SFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGA-- 1031 L EE + Q+ +V RELE +H + E ++ + ++ L V SR Sbjct: 641 DRLEEEQEDAVQDGARVR---RELE--RSHRQLEQLEGKRSVLAKELVEVREALSRATLQ 695 Query: 1032 ----EGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLI-------------LDH 1074 + ++V ++ + VE ++S + E S Q+ L LD Sbjct: 696 RDMLQAEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDL 755 Query: 1075 LPSVTKESSLRATQPSENDKLQKELNVLKSEQ---NDLRLQMEAQRICLSLVYSTHVDQV 1131 V + ++ + ++E V + EQ +LRL+ E R Q Sbjct: 756 NRLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVAR------------QG 803 Query: 1132 REYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQ-TMKTQETGDEGKPLHLLIGK 1190 E ++A +L+++L + E+ + +++ QL Q + + QE + + Sbjct: 804 LEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEA 863 Query: 1191 LQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISEN------EDPELQD 1244 L++A E+ L + + L ++ A ++E G +SE E L+ Sbjct: 864 LERAAREK---------EALAKEHA-GLAVQLVAAERE--GRTLSEEATRLRLEKEALEG 911 Query: 1245 YRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSK---------IWGQQTDGMKLEFGEE 1295 +EVQ + ++ E LL+ + L+ I Q+ + E + Sbjct: 912 SLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQ 971 Query: 1296 NLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLK 1355 L + E E +L + H+ L LQ ++ E E L S LQ++ + Sbjct: 972 KLVQAERE------AQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQE 1025 Query: 1356 ETEQNYEAEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTM----YPGSCVKKNID 1411 E EAE L + + A+ + + +++ ES+ Q+ + + + + + Sbjct: 1026 ELLARLEAEKEELSEEIAALQQER------DEGLLLAESEKQQALSLKESEKTALSEKLM 1079 Query: 1412 GTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENT 1471 GT ++ E + + Q +++ + + S Q E + + +E Sbjct: 1080 GTRHSLATISLEMER---QKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVR 1136 Query: 1472 ASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGE--HGKEIL 1529 +QA + +Q E + + Q+ + E + E ++L E G+E+ Sbjct: 1137 RLQEQARDLGKQRDSCLREAEELRTQL--RLLEDARDGLRRELLEAQRKLRESQEGREVQ 1194 Query: 1530 LSNSDP-----HDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNE 1584 + + + ++ + +EE+ S K +S + +++ D ++L L E Sbjct: 1195 RQEAGELRRSLGEGAKEREALRRSNEELRSAVKK---AESERISLKLANEDKEQKLALLE 1251 Query: 1585 EQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSID 1644 E + +E + + Q E R R+++ R + L E RL R+LA+ + Sbjct: 1252 EARTAVGKE-AGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAE---LQ 1307 Query: 1645 NENLVSER-ERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQTFKEK 1703 + ER E+ E L+Q L G L E+ Q Q +++EQ + + Sbjct: 1308 GRLALGERAEKESRRETLGLRQRLLKGEASL--EVMRQELQVA-----QRKLQEQEGEFR 1360 Query: 1704 ELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSS-- 1761 +R+ E E+ L A R L++ LE + AA +G + R+ Sbjct: 1361 TRERRLLGSLEEARGTEKQQLDHA--RGLELKLEAARAEAA---ELGLRLSAAEGRAQGL 1415 Query: 1762 KSQSSASLIWRSEAEA---SVKSCVHE-----EHTRVTDESIPSYSGSDMPR----NDIN 1809 +++ + + R AEA ++S + +P D P +N Sbjct: 1416 EAELARVEVQRRAAEAQLGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLN 1475 Query: 1810 MWSKV-TEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQL 1868 S + G++ + A ++DPE ++ A+ + L+ + + Sbjct: 1476 SPSTLECSPGSQPPSPGPATSPASPDLDPE----------AVRGALREFLQELRSAQRER 1525 Query: 1869 EHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYA 1928 + + + L R+ + E + +L++ + E AR + +G + G Sbjct: 1526 DELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAESEEARRSV-------DGRLSGVQ 1578 Query: 1929 DEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAG 1988 E L E ++ R E+E +++ LE Q E EL + Q++ K +A Sbjct: 1579 AELALQEESVR-------RSERERRATLDQVATLERSLQ--ATESELRASQEKISKMKAN 1629 Query: 1989 PVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTEL 2048 + L+ ++ +KE L+ ++ V+ +LQ+ ++LE ++ Q L Sbjct: 1630 ETK---LEGDKRRLKEVLDAS-ESRTVKLELQR--RSLEGEL-----------QRSRLGL 1672 Query: 2049 MDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQT 2108 D Q QAL+ +++ +++ Q D E + Q +++L L V + + Sbjct: 1673 SDREAQAQALQDRVDSLQR----QVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKV 1728 Query: 2109 REV-EQLA------NHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALL 2161 R + E LA N ++K + L + E ++ +QER + + R+ +L Sbjct: 1729 RGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQSSSLG 1788 Query: 2162 VEDRKHFGAVE--AKPELSLEVQLQAERDAIDRK---EKEITNLEEQLEQFREELENKNE 2216 + + G V + E QLQ R+ + ++ E N ++L+ R L+ + Sbjct: 1789 EQVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQERLG 1848 Query: 2217 EVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFA 2276 +Q+ QLE +K+E LE++ + ++K ++ S +D L + Sbjct: 1849 SLQRALAQLEAEKREVERSALRLEKDRVALRRTLDK----VEREKLRSHEDTVRLSAEKG 1904 Query: 2277 QI----------IQEKEVEIDQLNEQVTKLQQ-----QLKITTDNKVIEEKNEL--IRDL 2319 ++ + E + +I QL QV L+Q QL++ + +E + E+ +R Sbjct: 1905 RLDRTLTGAELELAEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQQQQLELQQEVERLRSA 1964 Query: 2320 ETQIECLMSDQECVKRNREEEI-EQLNEVIEKLQQEL 2355 + Q E + +E R R + EQ++ + +LQQEL Sbjct: 1965 QAQTERTLEARERAHRQRVRGLEEQVSTLKGQLQQEL 2001 Score = 119 bits (297), Expect = 8e-26 Identities = 222/1024 (21%), Positives = 414/1024 (40%), Gaps = 162/1024 (15%) Query: 25 AQSDGQSPSKKQKKKRKTSSSKHDVSAHHDLNIDQSQCNEMYINSSQRVESTVIPESTIM 84 AQ QS K + + V N+++ Q N+ + +ES + E + Sbjct: 382 AQQQMQSDLDKADLSARVTELGLAVKRLEKQNLEKDQVNKDLTEKLEALESLRLQEQAAL 441 Query: 85 RT------------LHSGEITSHEQGFSVELESEISTTADDCSSEVNGCSFVMRTGKPTN 132 T L ++ E G + S TAD + + G S RT P Sbjct: 442 ETEDGEGLQQTLRDLAQAVLSDSESGVQL---SGSERTADASNGSLRGLSG-QRTPSPPR 497 Query: 133 LLREEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHEIEELNRELEEMRVTYGTEGLQQ 192 DS T L ++ S L +Q +++++ E + GT +Q Sbjct: 498 RSSPGRGRSPRRGPSPACSDSST-LALIHSALHKRQLQVQDMRGRYEASQDLLGTLR-KQ 555 Query: 193 LQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQIQFQQLQASETLR 252 L + E+ + L LQ+ R + D M+ + + Q+L+ A+E L Sbjct: 556 LSDSESERRA-------LEEQLQRLRDKTDGAMQAHEDAQREVQRLR------SANELL- 601 Query: 253 NSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQ 312 S S A LQ QQ Q EE E Q +E+ Q L+E EQ Sbjct: 602 -SREKSNLAHSLQVAQQ------QAEELRQEREKLQAAQEELRRQRDRLEE-------EQ 647 Query: 313 DKKVENSNK--EEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKN 370 + V++ + E++ +E+L K K+ +E+++ L+ A LQ + + Sbjct: 648 EDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVA 707 Query: 371 Q-----EIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQE 425 + E ++LEL+ +K + ++S L ++ +L N +Q + D+ Sbjct: 708 EALTKAEAGRVELELSMTKLRAEEAS-----LQDSLSKLSALNESLAQDKLDL------- 755 Query: 426 TQRKLEQLRAELDEMYGQQIVQMKQE--LIRQHMAQMEEMKTRHKGEMENALRSYSNITV 483 R + QL E + G+Q Q +QE + R+ ++EE++ + Sbjct: 756 -NRLVAQLEEEKSALQGRQR-QAEQEATVAREEQERLEELRLEQE--------------- 798 Query: 484 NEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQ 543 VA L L+ +E L+++L + E+ LQ QL L +LS ++ Sbjct: 799 ---------VARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQE 849 Query: 544 IQRARQTIAEQESKLNEAHKSLSTVED----LKAEIVSA-------SESRKELELKHEA- 591 +++AR+ Q L A + + L ++V+A SE L L+ EA Sbjct: 850 LEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEAL 909 Query: 592 ---------EVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKE 642 ++ + + E LE E A+L E+ EL LR Q++ + E+ + L + Sbjct: 910 EGSLFEVQRQLAQLEARREQLEAEGQALL-LAKETLTGELAGLRQQIIATQEK--ASLDK 966 Query: 643 DLEIEHRINIEK-----LKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLIL 697 +L + + E+ L++ H ++ + LQ E ++ E+ L Q+QL Sbjct: 967 ELMAQKLVQAEREAQASLREQRAAH-EEDLQRLQREKEAAWRELEAERAQL---QSQLQR 1022 Query: 698 EISKLKDLQQSLVNSKSEEMTLQINELQKEIE---ILRQEEKEKGTLEQEVQELQLKTEL 754 E +L + + ++ EE++ +I LQ+E + +L + EK++ +E ++ L +L Sbjct: 1023 EQEELL----ARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKL 1078 Query: 755 L-------------EKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEE 801 + E+Q ++ ++ ++ + + A S L+D + E+ H +QE Sbjct: 1079 MGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAH---AQEV 1135 Query: 802 RLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNY 861 R ++ +++D K+ + + E E+L+ Q L + + R A++ Sbjct: 1136 R-----RLQEQARDL--GKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKL---- 1184 Query: 862 QELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDK 921 +E QE + +L S + E + L+ NEEL + ++ + +EDK Sbjct: 1185 RESQEGREVQRQEAGELRRSLGEGAKE-REALRRSNEELRSAVKKAESERISLKLANEDK 1243 Query: 922 TFVAETLEMGEV-VEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEV 980 LE V K+ EL L+ +R +LE + L +L Q+K E + L E+ Sbjct: 1244 EQKLALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGREL 1303 Query: 981 KSLK 984 L+ Sbjct: 1304 AELQ 1307 Score = 113 bits (283), Expect = 3e-24 Identities = 294/1528 (19%), Positives = 630/1528 (41%), Gaps = 185/1528 (12%) Query: 1335 KLEEQVQEL-------ESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSESTVPPSLPVD 1387 K + QVQ++ + L+ +L++QL ++E +E L+++LQ + + T D Sbjct: 530 KRQLQVQDMRGRYEASQDLLGTLRKQLSDSE----SERRALEEQLQRLRDKT-------D 578 Query: 1388 SVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLE--KQYQEQLEEEVA 1445 + DAQR + + + E +E++N+ L+ +Q E+L +E Sbjct: 579 GAMQAHEDAQREVQ-----------RLRSANELLSREKSNLAHSLQVAQQQAEELRQERE 627 Query: 1446 KVIVSMSIAFAQQTELSR-----ISGGKENTASSKQAHAVCQQEQ--------------H 1486 K+ + Q+ L + G +++H +Q + Sbjct: 628 KLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVRE 687 Query: 1487 YFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVL 1546 + L +D + + E + K E + EL + ++ + +S + Sbjct: 688 ALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELS-----MTKLRAEEASLQDSLSKLS 742 Query: 1547 TISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNE--------EQLEDMR--QELVR 1596 ++E + ++DK + R E S++ ++ E E+LE++R QE+ R Sbjct: 743 ALNESL-AQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVAR 801 Query: 1597 QYQEHQ-QATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERV 1655 Q E + E ++A +Q+ R ++ QLQE++ +L+RQL+ R E + + R Sbjct: 802 QGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGR-----EQELEQARRE 856 Query: 1656 LLEELEALKQLSLAGREKLCCELRNSSTQTQ-NGNENQGEVEEQTFKEKELDRKPEDVPP 1714 ++EAL++ A REK ++ Q E +G + L++ E + Sbjct: 857 AQRQVEALER---AAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEK--EALEG 911 Query: 1715 EILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSE 1774 + +R Q R + L + +ET+ + G+ + +Q ASL Sbjct: 912 SLFEVQRQLAQLEARR--EQLEAEGQALLLAKETLTGELAGLRQQIIATQEKASLDKELM 969 Query: 1775 AEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVR-SGFAGT 1833 A+ V++ + + + + R W ++ E +L +L R Sbjct: 970 AQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQEELLA 1029 Query: 1834 EIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQE-ATES 1892 ++ E EEL I++ Q E LL A SE L + +T L + + AT S Sbjct: 1030 RLEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATIS 1089 Query: 1893 LKCQEELRE---RLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLE 1949 L+ + + R+ R ++ L EL + A R++QE+ + + Sbjct: 1090 LEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQR 1149 Query: 1950 QELLCASNRLQELEAEQQQIQE-----ERELLSRQKEAMKAEAG-PVEQQLLQETEKLMK 2003 L +EL + + +++ RELL Q++ +++ G V++Q E + + Sbjct: 1150 DSCL---REAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAGELRRSLG 1206 Query: 2004 EKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLE 2063 E + + + ++L+ VK E E++S + ++K +L L + A+ K+ Sbjct: 1207 EGAKEREALRRSNEELRSAVKKAE---SERISLKL-ANEDKEQKLALLEEARTAVGKEAG 1262 Query: 2064 KMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLK--EK 2121 ++R L E E R ++E+Q+L +Q+K++ + RE+ +L L E+ Sbjct: 1263 ELRTGLQEV----ERSRLEARRELQELRRQMKML---DSENTRLGRELAELQGRLALGER 1315 Query: 2122 TDKCS--ELLLSKEQL---QRDIQERNEEIEKLEFRVRELEQALLVEDRKHFGAVE---- 2172 +K S E L +++L + ++ +E++ + +++E E +R+ G++E Sbjct: 1316 AEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARG 1375 Query: 2173 -AKPEL----SLEVQLQAERD-------AIDRKEKEITNLEEQLEQFREELENKNEEVQ- 2219 K +L LE++L+A R + E LE +L R E++ + E Q Sbjct: 1376 TEKQQLDHARGLELKLEAARAEAAELGLRLSAAEGRAQGLEAELA--RVEVQRRAAEAQL 1433 Query: 2220 -----QLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGK 2274 L L + + S + + GL + S Q G Sbjct: 1434 GGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPSPGP 1493 Query: 2275 FAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVK 2334 A +++ + + + + Q+L+ E++EL R + + +++ E + Sbjct: 1494 -ATSPASPDLDPEAVRGALREFLQELR-----SAQRERDEL-RTQTSALNRQLAEMEAER 1546 Query: 2335 RNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQV 2394 + QL + + + ++ ++ + S L+ + +S++ E+ A QV Sbjct: 1547 DSATSRARQLQKAVAESEEARRSVDGRLSGVQAELALQEESVRRS----ERERRATLDQV 1602 Query: 2395 ETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDK 2454 T + ++ L+ + K++++ L+ ++ ++++ E+ L + Sbjct: 1603 ATLERSLQATESELRASQEKISKMKANETKLEGDKRRLKEVLDASESRT----VKLELQR 1658 Query: 2455 PELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQI 2514 LE L L + + ++ ++ + +L+ ++ +S V A L+LT +++ Sbjct: 1659 RSLEGELQRSRLGLSDREAQAQALQDR----VDSLQRQV--ADSEVKAGTLQLT--VERL 1710 Query: 2515 KDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPE 2574 + + L+ K+ L + + + A+ ++ + +Q+ C+ ++ + E Sbjct: 1711 NGALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERL 1770 Query: 2575 RTNIQNLNQLRE--DELGSDISALTLRISELESQVVEMHTSL------ILEKEQVEIAEK 2626 Q L++ R+ LG + L +++LE Q VE L + ++++ E A Sbjct: 1771 DAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQEGEAAAL 1830 Query: 2627 NVLEK---EKKLLE-----LQKLLEGNEKKQREKEKK--RSPQDVEVLKTT-----TELF 2671 N ++K E++LL+ LQ+ L E ++RE E+ R +D L+ T E Sbjct: 1831 NTVQKLQDERRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVALRRTLDKVEREKL 1890 Query: 2672 HSNEESGFFN-ELEALRAESVATKAELASYKEKAEKLQEELLVKETNMT--SLQKDLSQV 2728 S+E++ + E L + ELA + + ++L+ +++V E + + L+ D Q Sbjct: 1891 RSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQQQ 1950 Query: 2729 RDHLAEAKEKLSILEKEDETEVQESKKA 2756 + L + E+L + + E ++ ++A Sbjct: 1951 QLELQQEVERLRSAQAQTERTLEARERA 1978 Score = 112 bits (280), Expect = 7e-24 Identities = 394/1950 (20%), Positives = 781/1950 (40%), Gaps = 287/1950 (14%) Query: 1988 GPVEQQLLQETEKLMKEKLE--VQCQAEKV--RDDLQK-QVKALEIDVEEQVSRFIE--- 2039 G Q ++ T + + + LE V CQ + + RD Q Q+ +L + E V+R + Sbjct: 4 GLARAQEVELTLETVIQTLESSVLCQEKGLGARDLAQDAQITSLPALIREIVTRNLSQPE 63 Query: 2040 ----LEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLK 2095 L + L+ L+++NQ L+++L ++ L + +R+ + ++LEQ L+ Sbjct: 64 SPVLLPATEMASLLSLQEENQLLQQELSRVEDLLAQSRAERDELAIKYNAVSERLEQALR 123 Query: 2096 VVPRFQPISEHQ--TREVEQLANHLKEKTDKCSELLLSKEQLQRD----IQERNEEIEKL 2149 + P E + R+ +L L+E+ L + ++ Q+ +Q +I + Sbjct: 124 LEPGELETQEPRGLVRQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQGKILQY 183 Query: 2150 EFRVRELEQALL-----VEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQL 2204 + R ELEQ LL +E ++ ++ S ++L+ E+ + L EQL Sbjct: 184 KKRCSELEQQLLERSGELEQQRLRDTEHSQDLESALIRLEEEQQRSASLAQVNAMLREQL 243 Query: 2205 EQFREELENKNEEVQQL-----HMQLEIQKKESTTRLQELEQENKLFKDDMEKLGL---- 2255 +Q + +E+++++ + E++ +E+ R +E E N F ++ +L L Sbjct: 244 DQAGSANQALSEDIRKVTNDWTRCRKELEHREAAWRREE-ESFNAYFSNEHSRLLLLWRQ 302 Query: 2256 ------AIKESDAMSTQDQHVLFGKFA---QIIQE-----------KEVEIDQLNEQVTK 2295 + E + +D L G+ A + +QE E + E+ Sbjct: 303 VVGFRRLVSEVKMFTERDLLQLGGELARTSRAVQEAGLGLSTGLRLAESRAEAALEKQAL 362 Query: 2296 LQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQEL 2355 LQ QL+ +KV+ EK+ + +++ ++ K + + +L +++L+++ Sbjct: 363 LQAQLEEQLRDKVLREKDLAQQQMQSDLD---------KADLSARVTELGLAVKRLEKQ- 412 Query: 2356 ANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKM 2415 N+ +K +N L+E+ ++L E L L++Q E+ ++ L Sbjct: 413 -NL-EKDQVN-KDLTEKLEAL---------ESLRLQEQAALETEDGEGLQQTL------- 453 Query: 2416 NQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYF 2475 R+ + + S E+ V ++ + D + +L+ L Q Sbjct: 454 -------------RDLAQAVLSDSESGVQLSGSERTAD-------ASNGSLRGLSGQRTP 493 Query: 2476 KSFEENGKG---SIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKI 2532 + G S + ST++ L + Q++DM +G++E Q + Sbjct: 494 SPPRRSSPGRGRSPRRGPSPACSDSSTLALIHSALHKRQLQVQDM--RGRYEAS--QDLL 549 Query: 2533 VNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSD 2592 L+K + + + + QL+ +++ D + E + +Q L E L + Sbjct: 550 GTLRKQLSDSESERRALEEQLQRLRDKT----DGAMQAHEDAQREVQRLRSANE-LLSRE 604 Query: 2593 ISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLE-----------LQKL 2641 S L + + Q E+ E+E+++ A++ + + +L E +++ Sbjct: 605 KSNLAHSLQVAQQQAEELRQ----EREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRE 660 Query: 2642 LEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEA------LRAESVATKA 2695 LE + ++ + E KRS E+++ L + + +A +AE+ + Sbjct: 661 LERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVEL 720 Query: 2696 ELASYKEKAEK--LQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQES 2753 EL+ K +AE+ LQ+ L SL +D + +A+ +E+ S L+ QE+ Sbjct: 721 ELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEA 780 Query: 2754 KKACMFEPL--PIKLSKSIASQ-TDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVT 2810 A + ++L + +A Q +G+L++ + Q + L + + +S+ E++ Sbjct: 781 TVAREEQERLEELRLEQEVARQGLEGSLRV--AEQAQEALEQQLPTLRHERSQL-QEQLA 837 Query: 2811 EIISQFTEKIEKMQEL--HAAEILDMESRHISETETLKREHY-VAVQL---------LKE 2858 ++ Q + + +++++ A ++ R E E L +EH +AVQL L E Sbjct: 838 QLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSE 897 Query: 2859 ECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIASE 2918 E L+ + L +LA +A RE ++ GQ + L + E Sbjct: 898 EATRLRLEKEALEGSLFEVQRQLAQLEA--RREQLEAE-----GQALLLAKE---TLTGE 947 Query: 2919 GRG-EESESATDSFPKKIKGLL--RAVHNEGMQVLSLTESPYSDGED-HSIQQVSE-PWL 2973 G + AT K L+ + V E SL E + ED +Q+ E W Sbjct: 948 LAGLRQQIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWR 1007 Query: 2974 EERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVL 3033 E S L+ ++ + EAE + S+ + R E LL + E+ Sbjct: 1008 ELEAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLLLAE----SEKQQA 1063 Query: 3034 LAAFRTELTAL-----GTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQA 3088 L+ +E TAL GT ++ ++ LE Q++ + + + ++ +L SE++ Sbjct: 1064 LSLKESEKTALSEKLMGTRHSLATIS-LEMERQKRDAQSRQEQD---RSTVNALTSELRD 1119 Query: 3089 LHAQ------MNGRKITLKREQESEKPSQE---LLEYNIQQKQSQMLE-----MQVELSS 3134 L AQ + +++ +EQ + Q L E + Q ++LE ++ EL Sbjct: 1120 LRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLE 1179 Query: 3135 MKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHK---HLKELEAFRLEVK-- 3189 + + E QE ++ EL+ L + E E ++ + +K+ E+ R+ +K Sbjct: 1180 AQRKLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLA 1239 Query: 3190 --DKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQR 3247 DK ++ LL + + K++ EL+ L+ ++ RS + EL++L+ ++ Sbjct: 1240 NEDKEQKLALLEEARTAVGKEAGELRTGLQ----EVERSRLEARRELQELRRQMKMLDSE 1295 Query: 3248 NLQLNL-LLEQQKQLLNESQQKIESQRM---LYDAQLSEEQGRNLELQVLLESEKVRIRE 3303 N +L L E Q +L + + ES+R L L E + Q L +++ + Sbjct: 1296 NTRLGRELAELQGRLALGERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQ 1355 Query: 3304 MSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLK---------ELQKQLEEKHSRIVEL 3354 RER L L+ + GT + + LK EL +L R L Sbjct: 1356 EGEFRTRERRLLGSLEEARGTEKQQLDHARGLELKLEAARAEAAELGLRLSAAEGRAQGL 1415 Query: 3355 LNETEKYKLDSLQTRQQMEKDRQVHRKTL---------------QTEQEANTEGQKKMHE 3399 E + ++ Q+ R R+ L ++A EG + Sbjct: 1416 EAELARVEVQRRAAEAQLGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLN 1475 Query: 3400 LQSKVE---DLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELEREEKRESRRILYQNL 3456 S +E Q DL+ + ++G ++EF ++ + +R+ R L Sbjct: 1476 SPSTLECSPGSQPPSPGPATSPASPDLDPEAVRGALREFLQELRSAQRERDELRTQTSAL 1535 Query: 3457 NEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEM---------- 3506 N + ++R ++++ ES A+ ++G +G EL + Sbjct: 1536 NRQLA-EMEAERDSATSRARQLQKAVAESEEARR-SVDGRLSGVQAELALQEESVRRSER 1593 Query: 3507 -----------IRQKLQCVASKLQVLPQKASERLQFETADDEDFIWVQENID-------E 3548 + + LQ S+L+ +K S+ ET + D ++E +D + Sbjct: 1594 ERRATLDQVATLERSLQATESELRASQEKISKMKANETKLEGDKRRLKEVLDASESRTVK 1653 Query: 3549 IILQLQKLTGQ-QGEEPSLVSPSTSCGSLTER---LLRQ--NAELTGHISQLTEEKNDLR 3602 + LQ + L G+ Q L +L +R L RQ ++E+ QLT E+ L Sbjct: 1654 LELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVER--LN 1711 Query: 3603 NMVMKLEEQIRWYRQTGAGRDNS---SRFSLNGGANIEAIIASEKEVWNREKLTLQKSL- 3658 + K+EE R G + S SLN + + ++ LQ+ L Sbjct: 1712 GALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLD 1771 Query: 3659 --KRAEAEVYKLKAELRNDSLLQTLSPDSEHVTLKRIYGKYLRAESFRKALIYQKKYLLL 3716 ++A +E K + L +QTL + + L+R+ + + + R+ L +++ Sbjct: 1772 AARQALSEARKQSSSLGEQ--VQTLRGEVADLELQRVEAEG-QLQQLREVLRQRQEGEAA 1828 Query: 3717 LLGGFQECEDATLALLARMGG-QPAFTDLE 3745 L Q+ +D L R+G Q A LE Sbjct: 1829 ALNTVQKLQDERRLLQERLGSLQRALAQLE 1858 Score = 110 bits (275), Expect = 3e-23 Identities = 282/1401 (20%), Positives = 546/1401 (38%), Gaps = 149/1401 (10%) Query: 31 SPSKKQKKKRKTSSSKHDVSA----HHDLNIDQSQCNEMYINSSQRVESTVIPESTIMRT 86 SP + + +R S + D S H L+ Q Q +M R E++ T+ + Sbjct: 500 SPGRGRSPRRGPSPACSDSSTLALIHSALHKRQLQVQDM----RGRYEASQDLLGTLRKQ 555 Query: 87 LHSGEITSHEQGFSVELESEISTTADDCSSEVNGCSFVMRTGKPTNLLREEEFGVDDSYS 146 L E S + +L+ T + + V R LL E+ + ++S Sbjct: 556 LSDSE--SERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANELLSREKSNL--AHS 611 Query: 147 EQGAQDSPTHLEMMESELAGKQHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGI 206 Q AQ L +L Q E+ LEE + +G + +E E + +Q Sbjct: 612 LQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQ---- 667 Query: 207 ITQLTANLQQARREKDETMREFLELTEQSQKLQIQFQQLQA-----SETLRNSTHSSTAA 261 L+Q ++ +E +E+ E + +Q LQA +E L + Sbjct: 668 -------LEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVEL 720 Query: 262 DLLQAKQQI--LTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYE-----MEQDK 314 +L K + + Q L + L E + K D ++ L+E+ + EQ+ Sbjct: 721 ELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEA 780 Query: 315 KVENSNKEEIQE----KETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKN 370 V +E ++E +E + L + E+ L+ +L T +LQEQ+ Q + Sbjct: 781 TVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLS 840 Query: 371 QEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKL 430 +++ + EL ++++ ++ E +++ E L K H + +R + + Sbjct: 841 RQLSGREQELEQARREAQRQVEALERAAREKEALAK-EHAGLAVQLVAAEREGRTLSEEA 899 Query: 431 EQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKL 490 +LR E + + G +++ +AQ+E + + + E + L + +T ++ Sbjct: 900 TRLRLEKEALEGSLFE------VQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQ 953 Query: 491 MNVAINELNIKLQDTNSQK---------EKLKEELGLILEEKCALQRQLEDLVEELSFSR 541 +A E ++ +QK L+E+ E+ LQR+ E EL R Sbjct: 954 QIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAER 1013 Query: 542 EQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLE 601 Q+Q Q E+ EA K E+L EI + + R E L E+E L Sbjct: 1014 AQLQSQLQREQEELLARLEAEK-----EELSEEIAALQQERDEGLLLAESEKQQ---ALS 1065 Query: 602 MLEKEKNAVLDRMAESQEA------ELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKL 655 + E EK A+ +++ ++ + E+ER + E++ S + L E R ++ Sbjct: 1066 LKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNA-LTSELR-DLRAQ 1123 Query: 656 KDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSE 715 ++ + Q++ LQ ++ + ++D+ + + +L ++ L+D + L + Sbjct: 1124 REEAAAAHAQEVRRLQ----EQARDLGKQRDSCLREAEELRTQLRLLEDARDGL-RRELL 1178 Query: 716 EMTLQINELQKEIEILRQE----EKEKGTLEQEVQELQLKTELLEKQMKEKEND-LQEKF 770 E ++ E Q+ E+ RQE + G +E + L+ E L +K+ E++ + K Sbjct: 1179 EAQRKLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKL 1238 Query: 771 AQLEAENSI-LKDEKKTL--EDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIE 827 A + E + L +E +T ++ ++ T + + ER ++++ + +++++L Sbjct: 1239 ANEDKEQKLALLEEARTAVGKEAGELRTGLQEVER----SRLEARRELQELRRQMKMLDS 1294 Query: 828 ENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNK--- 884 EN L ++ +L + + + Q L + A L ++ +L+ ++ K Sbjct: 1295 ENTRLGRELAELQGRLALGERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQE 1354 Query: 885 QELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEK 944 QE E++++ + L L R ++ + A LE+ K Sbjct: 1355 QEGEFRTRERRLLGSLEEARGT-----------EKQQLDHARGLEL-------------K 1390 Query: 945 LEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHN 1004 LE + E EL RLS + + E++ EV+ E + LR L + Sbjct: 1391 LEAARAEAAELGLRLSAAEGRAQGLEAELA--RVEVQRRAAEAQLGGLR-SALRRGLGLG 1447 Query: 1005 RAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEE 1064 RA + S D AEGS +N E + + Sbjct: 1448 RAPSPAPRPVPGSPARDA-------PAEGSGEGLNSPSTLECSPGSQPPSPGPATSPASP 1500 Query: 1065 SKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVY 1124 + + L +E LR+ Q E D+L+ + + L N +MEA+R + Sbjct: 1501 DLDPEAVRGALREFLQE--LRSAQ-RERDELRTQTSAL----NRQLAEMEAERDSATSRA 1553 Query: 1125 STHVDQVREYMENEK--DKALCSLKEELIFAQEEKIKELQKIHQLELQTMKT-----QET 1177 V E E + D L ++ EL QEE ++ ++ + L + T Q T Sbjct: 1554 RQLQKAVAESEEARRSVDGRLSGVQAELAL-QEESVRRSERERRATLDQVATLERSLQAT 1612 Query: 1178 GDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISEN 1237 E + I K+ KA + + L VL + +K E+ E + Sbjct: 1613 ESELRASQEKISKM-KANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGE----LQR 1667 Query: 1238 EDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENL 1297 L D + Q Q+ + +L +V + K LQ + ++ G + E + Sbjct: 1668 SRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRDK 1727 Query: 1298 PKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQ---L 1354 + TE L+ S N H K + + ++ L+E++ +S ++Q L Sbjct: 1728 VRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQSSSL 1787 Query: 1355 KETEQNYEAEIHCLQ-KRLQA 1374 E Q E+ L+ +R++A Sbjct: 1788 GEQVQTLRGEVADLELQRVEA 1808 Score = 100 bits (248), Expect = 4e-20 Identities = 269/1416 (18%), Positives = 555/1416 (39%), Gaps = 177/1416 (12%) Query: 190 LQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQ-SQKLQIQFQQLQAS 248 L LQE ++Q + L A Q+R E+DE ++ ++E+ Q L+++ +L+ Sbjct: 76 LLSLQEENQLLQQELSRVEDLLA---QSRAERDELAIKYNAVSERLEQALRLEPGELETQ 132 Query: 249 ETLRNSTHSSTAADLLQAKQ-----QILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQE 303 E S LQ +Q ++ +Q+ + Q L++ Q K + + S L++ Sbjct: 133 EPRGLVRQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQGKILQYKKRCSELEQ 192 Query: 304 KI--KVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGE 361 ++ + E+EQ + + + ++++ +EE + + L+++L A Sbjct: 193 QLLERSGELEQQRLRDTEHSQDLESALIRLEEEQQRSASLAQVNAMLREQLDQAGSANQA 252 Query: 362 LQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQR 421 L E I + + + EL + + R+ E + +V Sbjct: 253 LSEDIRKVTNDWTRCRKELEHREAAWRREEESFNAYFSNEHSRLLLLWRQVVGFRRLVSE 312 Query: 422 MEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNI 481 ++ T+R L QL EL + + QE + ++R + +E + + Sbjct: 313 VKMFTERDLLQLGGEL-----ARTSRAVQEAGLGLSTGLRLAESRAEAALEKQALLQAQL 367 Query: 482 TVNEDQIKLMNVAINELNIKLQDTNSQKEKLK-----EELGLILE-------EKCALQRQ 529 E+Q++ + + E ++ Q S +K ELGL ++ EK + + Sbjct: 368 ---EEQLR--DKVLREKDLAQQQMQSDLDKADLSARVTELGLAVKRLEKQNLEKDQVNKD 422 Query: 530 LEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELE-LK 588 L + +E L R Q Q A +T + T+ DL ++S SES +L + Sbjct: 423 LTEKLEALESLRLQEQAALET--------EDGEGLQQTLRDLAQAVLSDSESGVQLSGSE 474 Query: 589 HEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKL-----KED 643 A+ +N ++ L ++ R + R S L+ + K Sbjct: 475 RTADASNGSLR--GLSGQRTPSPPRRSSPGRGRSPRRGPSPACSDSSTLALIHSALHKRQ 532 Query: 644 LEIEH-RINIEKLKDNLGIHYKQQIDGLQNE--MSQKIETMQFEKDNLITKQNQLILEIS 700 L+++ R E +D LG KQ D + ++++ ++ + D + E+ Sbjct: 533 LQVQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQ 592 Query: 701 KLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMK 760 +L+ + L KS + + Q++ E LRQE ++ L+ +EL+ + + LE++ + Sbjct: 593 RLRSANELLSREKSN-LAHSLQVAQQQAEELRQEREK---LQAAQEELRRQRDRLEEEQE 648 Query: 761 EKEND----------LQEKFAQLEAENSILKDE---------KKTLE-DMLKIH------ 794 + D + QLE + S+L E + TL+ DML+ Sbjct: 649 DAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAE 708 Query: 795 --TPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNE---EIEKQRNT 849 T + L K +++++ + + L NE L Q + LN ++E++++ Sbjct: 709 ALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSA 768 Query: 850 FSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTT 909 ++ E +EE L +++ LE +Q LE ++ +E Q++ T Sbjct: 769 LQGRQRQAEQEATVAREEQERLEELR--LEQEVARQGLEGSLRVAEQAQEALEQQL--PT 824 Query: 910 VKMKSSVFDEDKTFVAETL----EMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQ 965 ++ + S E ++ L + E ++ +E LE REK L++ + L+ Q Sbjct: 825 LRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQ 884 Query: 966 LKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVT 1025 L E L+EE L+ EKE + E++ + A Q + + +LL T Sbjct: 885 LVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQ-LEAEGQALLLAKET 943 Query: 1026 MTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLR 1085 +T G ++ + + I ++K S + + ++ Q + ++SLR Sbjct: 944 LT-----GELAGLRQQI-----IATQEKASLDKELMAQKLVQAER--------EAQASLR 985 Query: 1086 ATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCS 1145 + + + LQ+ L+ E+ ++EA+R L +++ +E EK++ Sbjct: 986 EQRAAHEEDLQR----LQREKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEE---- 1037 Query: 1146 LKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQT 1205 L EE+ Q+E+ + L + Q + +E+ + A+SE+ + Sbjct: 1038 LSEEIAALQQERDEGLLLAESEKQQALSLKESE-------------KTALSEKLMGTRHS 1084 Query: 1206 LCSVLGEYYTPALKCEVNAE-DKENSGDYISENEDPELQ------DYRYEVQDFQENMHT 1258 L ++ E + E D+ SE D Q + EV+ QE Sbjct: 1085 LATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARD 1144 Query: 1259 LLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGE-ENLPKEETEFLSIHSQMTNLEDI 1317 L + + L+T+L ++ DG++ E E + +E E + Q Sbjct: 1145 LGKQRDSCLREAEELRTQL-RLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAGELRR 1203 Query: 1318 DVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQ---LKETEQNYEAEIHCLQKRLQA 1374 + +K E+ L +EL S + + + LK ++ E ++ L++ A Sbjct: 1204 SLGEGAK-------EREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTA 1256 Query: 1375 VSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEK 1434 V + + V + +A+R + +E +K+L+ Sbjct: 1257 VGKEAGELRTGLQEVERSRLEARREL----------------------QELRRQMKMLDS 1294 Query: 1435 QYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMKLS 1494 + +L E+A++ +++ + E R + G +A +++ + KL Sbjct: 1295 E-NTRLGRELAELQGRLALGERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQ 1353 Query: 1495 QDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILL 1530 + + F+T E + EE + K+ +H + + L Sbjct: 1354 EQEGEFRTRERRLLGSLEEARGTEKQQLDHARGLEL 1389 Score = 90.9 bits (224), Expect = 2e-17 Identities = 208/1106 (18%), Positives = 450/1106 (40%), Gaps = 137/1106 (12%) Query: 158 EMMESELAGKQHEIEELNRELEEMRVTYGTEGLQQLQ-EFEAAIKQRDGIITQLTANLQQ 216 E+M +L + E + L E R + E LQ+LQ E EAA ++ + QL + LQ+ Sbjct: 967 ELMAQKLVQAEREAQA---SLREQRAAH-EEDLQRLQREKEAAWRELEAERAQLQSQLQR 1022 Query: 217 ARRE--------KDETMREFLELT-EQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAK 267 + E K+E E L E+ + L + + Q + +L+ S ++ + L+ + Sbjct: 1023 EQEELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMGTR 1082 Query: 268 QQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQD----------KKVE 317 + T ++E Q D Q ++E ++ L +++ +++ ++++ Sbjct: 1083 HSLATISLEMERQKR---DAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQ 1139 Query: 318 NSNKEEIQEKETII---EELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIK 374 ++ +++++ + EEL T++ E L+ +L A + L E QE + QE Sbjct: 1140 EQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAG 1199 Query: 375 NMKLEL-TNSKQKE--RQSSEEIKQLMGTVEELQ---KRNHKDSQFETDIVQRMEQETQR 428 ++ L +K++E R+S+EE++ + E + K ++D + + +++ + Sbjct: 1200 ELRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGK 1259 Query: 429 KLEQLRAELDEMYGQQIVQMKQEL--IRQHMAQMEEMKTRHKGEM----------ENALR 476 + +LR L E+ ++ + ++EL +R+ M ++ TR E+ E A + Sbjct: 1260 EAGELRTGLQEVERSRL-EARRELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEK 1318 Query: 477 SYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEE 536 T+ Q L A L + Q+ + KL+E+ G E + +R L L E Sbjct: 1319 ESRRETLGLRQRLLKGEA--SLEVMRQELQVAQRKLQEQEG---EFRTRERRLLGSLEEA 1373 Query: 537 LSFSREQIQRARQTIAEQESKLNEAHK---SLSTVEDLKAEIVSASESRKELELKH-EAE 592 ++Q+ AR + E+ EA + LS E +A+ + A +R E++ + EA+ Sbjct: 1374 RGTEKQQLDHARGLELKLEAARAEAAELGLRLSAAEG-RAQGLEAELARVEVQRRAAEAQ 1432 Query: 593 VTNYKIKLEM------------LEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKL 640 + + L + D AE L T + S Sbjct: 1433 LGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPSPG 1492 Query: 641 KEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNE----------MSQKIETMQFEKDNLIT 690 ++ E ++ L + Q++ Q E +++++ M+ E+D+ + Sbjct: 1493 PATSPASPDLDPEAVRGALR-EFLQELRSAQRERDELRTQTSALNRQLAEMEAERDSATS 1551 Query: 691 KQNQLILEISKLKDLQQSL---VNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQE 747 + QL +++ ++ ++S+ ++ E+ LQ E + R E + + TL+Q Sbjct: 1552 RARQLQKAVAESEEARRSVDGRLSGVQAELALQ------EESVRRSERERRATLDQ---- 1601 Query: 748 LQLKTELLEKQMKEKENDL---QEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLI 804 LE+ ++ E++L QEK ++++A + L+ +K+ L+++L + E R + Sbjct: 1602 ----VATLERSLQATESELRASQEKISKMKANETKLEGDKRRLKEVLD-----ASESRTV 1652 Query: 805 FLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQEL 864 L+ + + + + + D + Q L + ++ + + +E + Sbjct: 1653 KLELQRRSLEGELQRSRLGL-----SDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTV 1707 Query: 865 QEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFV 924 + L KV++ E + K++ L E L + + + K+ + T Sbjct: 1708 ERLNGALAKVEES--------EGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALT-- 1757 Query: 925 AETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLK 984 E D L E+L+ ++ E ++ S L EQ++ GE++ L + + Sbjct: 1758 --------ACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAE 1809 Query: 985 QEKEQVS--LRCRELEIIINHNRAENVQS----CDTQVSSLLDGVVTMTSRGAEGSVSKV 1038 + +Q+ LR R+ N + +Q ++ SL + + + E S + Sbjct: 1810 GQLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQRALAQLEAEKREVERSAL 1869 Query: 1039 NKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSEN-DKLQK 1097 + DKV E + E++ + L + L + +L+ Sbjct: 1870 RLEKDRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLEA 1929 Query: 1098 ELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEK 1157 ++ VL+ + +L+++AQ+ L L + + +A + + EE+ Sbjct: 1930 QVVVLEQSHSPAQLEVDAQQQQLELQQEVERLRSAQAQTERTLEARERAHRQRVRGLEEQ 1989 Query: 1158 IKELQKIHQLELQTMKTQETGDEGKP 1183 + L+ Q EL+ + G P Sbjct: 1990 VSTLKGQLQQELRRSSAPFSPPSGPP 2015 Score = 78.6 bits (192), Expect = 1e-13 Identities = 204/1099 (18%), Positives = 443/1099 (40%), Gaps = 154/1099 (14%) Query: 2 EDEERQKKLEAGKAKLAQFRQRKAQSDGQSPSKKQKKKRKTSSSKHDVSAHHDLNIDQSQ 61 E E ++LEA +A+L QR+ + + ++ + +K + S + D + ++ Sbjct: 1001 EKEAAWRELEAERAQLQSQLQREQE---ELLARLEAEKEELSEEIAALQQERDEGLLLAE 1057 Query: 62 CNEMYINSSQRVESTVIPESTIMRTLHSGEITSHEQGFSVELESEISTTADDCSSEVNGC 121 + S + E T + E +M T HS S E + + + + S VN Sbjct: 1058 SEKQQALSLKESEKTALSEK-LMGTRHSLATISLEME---RQKRDAQSRQEQDRSTVNAL 1113 Query: 122 SFVMRT------------GKPTNLLREE--EFGVDDSYSEQGAQDSPTHLEMMESELAGK 167 + +R + L+E+ + G + A++ T L ++E G Sbjct: 1114 TSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGL 1173 Query: 168 QHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMRE 227 + E+ E R+L E + EG +++Q EA +R A ++A R +E +R Sbjct: 1174 RRELLEAQRKLRESQ-----EG-REVQRQEAGELRRS---LGEGAKEREALRRSNEELRS 1224 Query: 228 FLELTEQSQKLQIQF------QQLQASETLRNSTHSSTAADLLQAKQQI----LTHQQQL 277 ++ E S+++ ++ Q+L E R + A +L Q++ L +++L Sbjct: 1225 AVKKAE-SERISLKLANEDKEQKLALLEEARTAV-GKEAGELRTGLQEVERSRLEARREL 1282 Query: 278 EEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEM-EQDKKVENSN-KEEIQEKETIIEELN 335 +E ++ + +++ LQ ++ + E E++ + E ++ + + E +E + Sbjct: 1283 QELRRQMKMLDSENTRLGRELAELQGRLALGERAEKESRRETLGLRQRLLKGEASLEVMR 1342 Query: 336 TKIIEEEKKTLELKDKLTTADK-LLGELQEQIVQKNQEI---KNMKLELTNSKQKERQSS 391 ++ ++K E + + T ++ LLG L+E + Q++ + ++L+L ++ + + Sbjct: 1343 QELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHARGLELKLEAARAEAAELG 1402 Query: 392 EEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDE------------ 439 + G + L+ ++ VQR E Q L LR+ L Sbjct: 1403 LRLSAAEGRAQGLE------AELARVEVQRRAAEAQ--LGGLRSALRRGLGLGRAPSPAP 1454 Query: 440 --MYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINE 497 + G E + + ++ + + + S + + D + + A+ E Sbjct: 1455 RPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPATSPASPDLDP-EAVRGALRE 1513 Query: 498 LNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESK 557 +L+ ++++L+ + AL RQL ++ E + + ++ ++ +AE E Sbjct: 1514 FLQELRSAQRERDELRTQTS-------ALNRQLAEMEAERDSATSRARQLQKAVAESEEA 1566 Query: 558 LNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAES 617 LS V+ EL L+ E+ + E+E+ A LD++A + Sbjct: 1567 RRSVDGRLSGVQ-------------AELALQEES--------VRRSERERRATLDQVA-T 1604 Query: 618 QEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQK 677 E L+ ++L S +E++SK+K + + +++G + + + Sbjct: 1605 LERSLQATESELRAS-QEKISKMKAN--------------------ETKLEGDKRRLKEV 1643 Query: 678 IETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKE 737 ++ + L ++ L E+ + + L S ++++ + +++ LQ+++ E + Sbjct: 1644 LDASESRTVKLELQRRSLEGELQRSR-LGLSDREAQAQALQDRVDSLQRQV---ADSEVK 1699 Query: 738 KGTLEQEVQELQ---LKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKI- 793 GTL+ V+ L K E E +++K L E AQ A + +D+ L+ L Sbjct: 1700 AGTLQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTAC 1759 Query: 794 -HTPVSQEERLIFLDSIKSKSK--DSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTF 850 H +ERL S+++ S ++++ L E DL+ Q ++ ++++ R Sbjct: 1760 EHDRQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVL 1819 Query: 851 SFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTV 910 ++ QE A L L+D + + +L +L L V Sbjct: 1820 -----------RQRQEGEAAALNTVQKLQDERRL----LQERLGSLQRALAQLEAEKREV 1864 Query: 911 KMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKH 970 + + ++D+ + TL+ VE++ E EK L + L+ +L + Sbjct: 1865 ERSALRLEKDRVALRRTLDK---VEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQ 1921 Query: 971 GEISFLNEEVKSLKQEKE----QVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTM 1026 +I L +V L+Q +V + ++LE+ R + Q+ + + Sbjct: 1922 RQIQQLEAQVVVLEQSHSPAQLEVDAQQQQLELQQEVERLRSAQAQTERTLEARERAHRQ 1981 Query: 1027 TSRGAEGSVSKVNKSFGEE 1045 RG E VS + +E Sbjct: 1982 RVRGLEEQVSTLKGQLQQE 2000 Score = 72.8 bits (177), Expect = 6e-12 Identities = 97/474 (20%), Positives = 201/474 (42%), Gaps = 54/474 (11%) Query: 3102 REQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELA 3161 +E S + ++ L Q+ EM+ E S RA +LQ+ ++ + + L+ Sbjct: 1516 QELRSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAESEEARRSVDGRLS 1575 Query: 3162 QTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKA 3221 + EL ++ + +E A D+V L +L + + + R Q + K KA Sbjct: 1576 GVQAELALQEESVRRSERERRA-------TLDQVATLERSLQATESELRASQEKISKMKA 1628 Query: 3222 KLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLS 3281 + E DK L+++ L++ + R ++L L + L S+ + + +AQ Sbjct: 1629 NETKLEG-DKRRLKEV---LDASESRTVKLELQRRSLEGELQRSRLGLSDR----EAQAQ 1680 Query: 3282 EEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQ 3341 Q R LQ + +V+ + T++R A+++ S+G L++ Sbjct: 1681 ALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGA------------LRDKV 1728 Query: 3342 KQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQ 3401 + L E ++ LN T L + E DRQV ++ L ++A +E +K+ L Sbjct: 1729 RGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQSSSLG 1788 Query: 3402 SKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELER----EEKRESRRILYQNLN 3457 +V+ L+ ++ + Q + + + Q+L+ ++++ Q+ E ++ ++ RR+L + L Sbjct: 1789 EQVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQERLG 1848 Query: 3458 ----------------EPTTWSLTSDRTRNWVLQQKIEGETKESN------YAKLIEMNG 3495 E + L DR K+E E S+ A+ ++ Sbjct: 1849 SLQRALAQLEAEKREVERSALRLEKDRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLDR 1908 Query: 3496 GGTGCNHELEMIRQKLQCVASKLQVLPQKASERLQFETADDEDFIWVQENIDEI 3549 TG EL ++++Q + +++ VL Q S Q E + + +Q+ ++ + Sbjct: 1909 TLTGAELELAEAQRQIQQLEAQVVVLEQSHSP-AQLEVDAQQQQLELQQEVERL 1961 Score = 60.1 bits (144), Expect = 4e-08 Identities = 87/498 (17%), Positives = 210/498 (42%), Gaps = 39/498 (7%) Query: 5 ERQKKLEAGKAKLAQFRQRKAQSDGQSPSKKQKKKRKTSSSKHDVSAHHDLNIDQSQC-- 62 ER + A Q + +A+ D + +Q +K S + S L+ Q++ Sbjct: 1524 ERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAESEEARRSVDGRLSGVQAELAL 1583 Query: 63 -NEMYINSSQRVESTVIPESTIMRTLHSGEITSHEQGFSVELESEISTTADDCSSEVNGC 121 E S + +T+ +T+ R+L + T E S E S++ + Sbjct: 1584 QEESVRRSERERRATLDQVATLERSLQA---TESELRASQEKISKMKANETKLEGDKRRL 1640 Query: 122 SFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHEIEELNRELEEM 181 V+ + + E + E Q S L E++ Q ++ L R++ + Sbjct: 1641 KEVLDASESRTVKLE----LQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADS 1696 Query: 182 RVTYGTEGL--QQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQ 239 V GT L ++L A +++ +G + L +A + ++ +++ LQ Sbjct: 1697 EVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNS---TRDKNLHLQ 1753 Query: 240 IQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQIS 299 + + + L +A++Q + +Q++ + D + ++ + Q+ Sbjct: 1754 KALTACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQ 1813 Query: 300 FLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEE-----------LNTKIIEEEKKTLEL 348 L+E ++ + ++ + + +++Q++ +++E L + E E+ L L Sbjct: 1814 QLREVLR--QRQEGEAAALNTVQKLQDERRLLQERLGSLQRALAQLEAEKREVERSALRL 1871 Query: 349 KDKLTTADKLLGELQEQIVQKNQEIKNMKLE-------LTNSKQKERQSSEEIKQLMGTV 401 + + L +++ + ++ +++ + E LT ++ + ++ +I+QL V Sbjct: 1872 EKDRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQV 1931 Query: 402 EELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQME 461 L++ +H +Q E D Q+ + E Q+++E+LR+ + ++ ++ ++ RQ + +E Sbjct: 1932 VVLEQ-SHSPAQLEVD-AQQQQLELQQEVERLRSA--QAQTERTLEARERAHRQRVRGLE 1987 Query: 462 EMKTRHKGEMENALRSYS 479 E + KG+++ LR S Sbjct: 1988 EQVSTLKGQLQQELRRSS 2005 Score = 33.1 bits (74), Expect = 5.5 Identities = 83/422 (19%), Positives = 175/422 (41%), Gaps = 61/422 (14%) Query: 1254 ENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQT--DGMKLEFGEENLPKEETEFLSIHSQM 1311 + + TL + ++L Q ++SK+ +T +G K +E L E+ + + Q Sbjct: 1600 DQVATLERSLQATESELRASQEKISKMKANETKLEGDKRRL-KEVLDASESRTVKLELQR 1658 Query: 1312 TNLEDIDVNHKSKLSSLQDLEKTKL-----EEQVQELESLISSLQQQLKETE-------- 1358 +LE +L++++L E Q Q L+ + SLQ+Q+ ++E Sbjct: 1659 RSLEG-------------ELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQL 1705 Query: 1359 ---------QNYEAEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTM----YPGSC 1405 E L+ +++ ++E+ S ++S Q+ + + Sbjct: 1706 TVERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQV 1765 Query: 1406 VKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRIS 1465 +++ +D + E K+ +++ + ++ E + E+ +V + ++ R Sbjct: 1766 LQERLDAARQALSE-ARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQE 1824 Query: 1466 GGKE--NTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGE 1523 G NT Q QE+ + L+Q + + E ++ +++ L + L + Sbjct: 1825 GEAAALNTVQKLQDERRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVALRRTLDK 1884 Query: 1524 HGKEILLSNSDPHDIPESK---DCVLTISEEMFSKDKTFIVRQSIHDEISV---SSMDAS 1577 +E L S+ D + K D LT +E ++ + I Q + ++ V S A Sbjct: 1885 VEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQI--QQLEAQVVVLEQSHSPAQ 1942 Query: 1578 RQLMLNEEQLEDMRQEL--VRQYQEHQQATELLRQAHMRQMERQREDQ-----EQLQEEI 1630 ++ ++QLE ++QE+ +R Q + T R+ RQ R E+Q QLQ+E+ Sbjct: 1943 LEVDAQQQQLE-LQQEVERLRSAQAQTERTLEARERAHRQRVRGLEEQVSTLKGQLQQEL 2001 Query: 1631 KR 1632 +R Sbjct: 2002 RR 2003 >gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] Length = 2115 Score = 172 bits (437), Expect = 4e-42 Identities = 342/1706 (20%), Positives = 679/1706 (39%), Gaps = 229/1706 (13%) Query: 580 ESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSK 639 ++++E+ +V + L + + + ++ + ++ RL+ QL +E ++ Sbjct: 174 QAKREIRFLELQKVASSSSGNNFLSGSPASPMGDILQTPQFQMRRLKKQLA---DERSNR 230 Query: 640 LKEDLEIEHRINIEKLKDNLGIHYKQQID--GLQNEMSQKIETMQFEKDNLITKQNQLIL 697 + +LE+ + KD +Q+ID L NE E + L K L + Sbjct: 231 DELELELAENRKLLTEKDAQIAMMQQRIDRLALLNEKQAASPLEPKELEELRDKNESLTM 290 Query: 698 EISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEK 757 + + Q L KS+ M +IN+L +E L + +E + Q++Q+ EL E+ Sbjct: 291 RLHETLKQCQDLKTEKSQ-MDRKINQLSEENGDLSFKLREFASHLQQLQDAL--NELTEE 347 Query: 758 QMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKI-HTPVSQ-EERLIFLDSIKSKSKD 815 K + L EK AQLE E S +KK LE+ +I +SQ EE L L + K Sbjct: 348 HSKATQEWL-EKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKG 406 Query: 816 SVWEK--EIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLK 873 V ++E L +E L QL +E E +EE L Sbjct: 407 EVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQQLSS 466 Query: 874 VKDDLEDS-----KNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETL 928 + DL+ S + K+ELE S+ + + + +++ +D+ E Sbjct: 467 LITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQ----ELA 522 Query: 929 EMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEK- 987 + + ++ +L + L+ ++ L ++ LS LKQK ++ + E+ ++ +Q+ Sbjct: 523 GLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHA 582 Query: 988 EQVSLRCRELEIIINHNRA--ENVQSCDTQVSSLLD------GVVTMTSRGAEGSVSKVN 1039 +Q++ E E + A + +++ + + ++ L+ V A+ SV++ Sbjct: 583 QQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQ 642 Query: 1040 KSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPS----ENDKL 1095 + E S+ + E + E T +E + Q + L + +AT+ E D+L Sbjct: 643 REKAELSRKVEELQACVE--TARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQL 700 Query: 1096 QKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQE 1155 Q++L LK + + +E EK +A +L+E+ E Sbjct: 701 QEQLQALKES----------------------LKVTKGSLEEEKRRAADALEEQQRCISE 738 Query: 1156 EKIKELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYT 1215 K + + Q + + + +E K L + +L +A E + L + +T Sbjct: 739 LKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHT 798 Query: 1216 PALKCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQT 1275 +CE ++ + ED + ++ +Y FQE + TL + + +L + Sbjct: 799 AESECEQLVKEV---AAWRERYEDSQQEEAQYGAM-FQEQLMTLKEECEKARQELQEAKE 854 Query: 1276 RLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTK 1335 +++ I E L I Q L ++ N L +Q+ E Sbjct: 855 KVAGI-------------------ESHSELQISRQQNELAELHANLARALQQVQEKEV-- 893 Query: 1336 LEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSESTVPPSLPVDSVVITESD 1395 + Q+L +S+LQ+++ T + E+ L+ ++ E S + D Sbjct: 894 ---RAQKLADDLSTLQEKMAATSK----EVARLETLVRKAGEQQETASRELVKEPARAGD 946 Query: 1396 AQRTMYPGS-----CVKKNIDGTIEFSGE-FGVKEETNIVKLLEKQYQEQLEEEVAKVIV 1449 Q C + +E E G + E L+E Q Q+Q E Sbjct: 947 RQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEERG------ 1000 Query: 1450 SMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVK 1509 Q+ E++R++ + + + E + L++ ++ F T + Sbjct: 1001 ------QQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALAH 1054 Query: 1510 FKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEI 1569 E + +EL K L + ++ E + V + E++ K+K H Sbjct: 1055 ALTEKEGKDQELA---KLRGLEAAQIKELEELRQTVKQLKEQLAKKEKE-------HASG 1104 Query: 1570 SVSSMDASRQLMLNEEQLEDMRQE---LVRQYQEHQQATELLRQAHMRQMERQREDQEQL 1626 S + +A+ + +LE +R E L +Q Q+ Q+ + L R +E +R + + Sbjct: 1105 SGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLE----RSLEAERASRAER 1160 Query: 1627 QEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQ 1686 ++ L QL +++ +EL Q +LA ++ EL T+ Q Sbjct: 1161 DSALETLQGQLEEKA----------------QEL-GHSQSALASAQR---ELAAFRTKVQ 1200 Query: 1687 NGNENQGEVEEQTFK-EKELDRKPE---DVPPEILSNERYALQKA--NNRLLKILLEVVK 1740 + ++ + E + Q + +E +RK + E+ R L+K + L ++++ + Sbjct: 1201 DHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESE 1260 Query: 1741 TTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSG 1800 + +EE L +L + S S+ + A S + EE + +E+ Sbjct: 1261 KSQKLEER-----LRLLQAETASNSARA--------AERSSALREEVQSLREEAEKQRVA 1307 Query: 1801 SDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEA 1860 S+ R ++ + E EL Q L + + L L +S QA V +LL A Sbjct: 1308 SENLRQEL---TSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTST-QALVSELLPA 1363 Query: 1861 ISETSSQLEHAKVTQTELMRESFRQKQEAT-----ESLKCQEEL------RERLHEESRA 1909 QL+ + + RE Q ++A E L+ Q EL R+++ E+ R Sbjct: 1364 -KHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERT 1422 Query: 1910 REQLAVE----------LSKAEGVID----GYADEKTLFERQIQEKTDII-DRLEQELLC 1954 +QL E L KA G++ G + L + ++ + D ++ QEL Sbjct: 1423 AQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAA 1482 Query: 1955 ASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEK 2014 + E ++Q E + +R+ E M A+ + ++L+E ++ +E+ ++ Q E+ Sbjct: 1483 VR---ADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQ 1539 Query: 2015 VRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLR----------QQNQALEKQLEK 2064 + ++Q K VEE + + +Q + L+ Q+ Q L+ QL + Sbjct: 1540 LEVFQREQTK----QVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNE 1595 Query: 2065 MRKFLDEQAIDREHER----------DVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQL 2114 ++ L ++ EH + D +Q+ Q+L++QL+ + + Q ++ E E+L Sbjct: 1596 LQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERL 1655 Query: 2115 ANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVEDRKHFGAVEAK 2174 + L++ K E + L ++ ++ + ++R+L + + D +AK Sbjct: 1656 GHELQQAGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQLRDLGKFQVATDALKSREPQAK 1715 Query: 2175 PELSLEVQLQAERDAIDRKEKEITNL 2200 P+L L + D++D +E T L Sbjct: 1716 PQLDLSI------DSLDLSCEEGTPL 1735 Score = 172 bits (436), Expect = 6e-42 Identities = 321/1546 (20%), Positives = 620/1546 (40%), Gaps = 194/1546 (12%) Query: 2047 ELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLE--QQLKVVPRFQPIS 2104 +L D R LE +L + RK L E ++ + + QQ I +L + + +P Sbjct: 222 QLADERSNRDELELELAENRKLLTE----KDAQIAMMQQRIDRLALLNEKQAASPLEPKE 277 Query: 2105 EHQTREV-EQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVE 2163 + R+ E L L E +C +L K Q+ R I + +EE L F++RE L Sbjct: 278 LEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHL--- 334 Query: 2164 DRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHM 2223 L++ L + EE +E + Sbjct: 335 ----------------------------------QQLQDALNELTEEHSKATQEWLEKQA 360 Query: 2224 QLEIQKKESTTRLQE---LEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQ 2280 QLE KE + LQ+ LE++N++ + + +L E QD Q Sbjct: 361 QLE---KELSAALQDKKCLEEKNEILQGKLSQL-----EEHLSQLQDNPP---------Q 403 Query: 2281 EKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEE 2340 EK + + + T Q+ + +N ++ + E++ Q E + + + + EEE Sbjct: 404 EKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAE---RGHFEEE 460 Query: 2341 IEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEE 2400 +QL+ +I LQ ++N+ Q + L Q+ + +E L ++ ++E Sbjct: 461 KQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQE 520 Query: 2401 MTFMKNVLKETNFKMNQ-LTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEV 2459 + +K KE ++ Q L Q+ + + R VE++ S L + + +L+ Sbjct: 521 LAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSS-----------SLKQKEQQLKE 569 Query: 2460 VLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIK---D 2516 V + ++ + E + S+ + L QLE+ K +L +Q++ + Sbjct: 570 VAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANE 629 Query: 2517 MQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERT 2576 ++ Q Q++ L + VEE A V + E + A+ + + SE ++ Sbjct: 630 ARDSAQTSVTQAQREKAELSRKVEE--LQACVETARQEQHEAQAQVAELELQLRSEQQKA 687 Query: 2577 NIQNLNQLREDELGSDISAL--TLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKK 2634 + +D+L + AL +L++++ + + + LE++Q I+E Sbjct: 688 TEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKA------ 741 Query: 2635 LLELQKLLEGNEKKQREKEKKRSPQD-VEVLKTTTELFHSNEESGFFNEL-EALRAESVA 2692 E + L+E ++++++E E++R+ + +E H E EL EA+ A+ A Sbjct: 742 --ETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTA 799 Query: 2693 TKA------ELASYKEKAEKLQEE-----LLVKETNMTSLQKDLSQVRDHLAEAKEKLSI 2741 E+A+++E+ E Q+E + +E MT L+++ + R L EAKEK++ Sbjct: 800 ESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMT-LKEECEKARQELQEAKEKVAG 858 Query: 2742 LEKEDETEV--QESKKACMFEPLPI-------------KLSKSIASQTDGTLKISSSNQT 2786 +E E ++ Q+++ A + L KL+ +++ + S Sbjct: 859 IESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVAR 918 Query: 2787 PQILVKNAGIQINLQSECSSEEVTEIISQFTEKIEKMQELH------AAEILDMESRHI- 2839 + LV+ AG Q S +E + E +E+ Q A + ++ E+ + Sbjct: 919 LETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMG 978 Query: 2840 SETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREICSSDSGS 2899 +E E L+ + +EE G + + L + G + +LA A + + Sbjct: 979 NELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNAL 1038 Query: 2900 DWGQGIYLTHSQGFDIA---SEGRGEESESATDSFPKKIKGL--LRAVHNEGMQVLSLTE 2954 + + + T + A EG+ +E +IK L LR + + L+ E Sbjct: 1039 NEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKE 1098 Query: 2955 SPYSDGEDHSIQQV--SEPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFS 3012 ++ G + +EP + +A +S L+ K Q Q A+ + S E S Sbjct: 1099 KEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQ--ADSLERSLEAERAS 1156 Query: 3013 DWRGELLLALQQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAME 3072 + L Q LEE++ L ++ L + A + E + Q A Sbjct: 1157 RAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARG 1216 Query: 3073 CLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEM-QVE 3131 + + SL+S ++ + +N R++ K + E + E QK + L + Q E Sbjct: 1217 RQEAERKNSLISSLEEEVSILN-RQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQAE 1275 Query: 3132 LSSMKDRATELQEQLSSEKMVVAEL--KSELAQTKLELETTLKAQHKHL--KELEAFRLE 3187 +S RA E L E + E K +A L E T +A+ +EL+A++ + Sbjct: 1276 TASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQELKAWQEK 1335 Query: 3188 VKDKTDEV------HLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSL 3241 K + H L SE ++ L L+ E+A +E+R +EELE K + Sbjct: 1336 FFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAA---AEKRHREELEQSKQAA 1392 Query: 3242 ESQK------QRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLS---------EEQGR 3286 + QR L + L Q+ + Q++ +++ Y QLS E+ R Sbjct: 1393 GGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENR 1452 Query: 3287 NLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEE 3346 L + L + + + LD+ RE + Q ++ +E L E+Q++ + Sbjct: 1453 GLGERANLGRQFLEVE-----LDQAREKYVQELAAVRAD-------AETRLAEVQREAQS 1500 Query: 3347 KHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVED 3406 + + + E K+ L+ RQ+ +++RQ ++ + E K++ EL K+ D Sbjct: 1501 TARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLAD 1560 Query: 3407 LQRQLEEKRQQVYKLDLEG-------QRLQGIMQEFQKQELEREEKRESRRILYQNLNEP 3459 + + ++Q++ + +G QRLQ + E Q Q ++E+ E Y+ E Sbjct: 1561 SDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEH----YKLQMEK 1616 Query: 3460 TTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELE 3505 + + +N LQ+++ + K E+ HEL+ Sbjct: 1617 AKTHYDAKKQQNQELQEQLRSLEQLQKENK--ELRAEAERLGHELQ 1660 Score = 142 bits (359), Expect = 5e-33 Identities = 349/1803 (19%), Positives = 727/1803 (40%), Gaps = 307/1803 (17%) Query: 613 RMAESQEAELERLRTQLLFSHEEELSKLKEDLE-IEHRINIEK-------LKDNLGIHYK 664 ++ E E EL ++ T LL H SK D E E++I E L G++ Sbjct: 86 KVLEGSELELAKM-TMLLLYHSTMSSKSPRDWEQFEYKIQAELAVILKFVLDHEDGLNLN 144 Query: 665 QQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINEL 724 + ++ + + L +Q EI L+ Q + +S S L + Sbjct: 145 EDLENFLQKAPVPSTCSSTFPEELSPPSHQAKREIRFLE--LQKVASSSSGNNFLSGSPA 202 Query: 725 QKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEK 784 +IL+ + + L++++ + + + LE ++ E L EK AQ+ Sbjct: 203 SPMGDILQTPQFQMRRLKKQLADERSNRDELELELAENRKLLTEKDAQI----------- 251 Query: 785 KTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWE-KEIEILIEENEDLK-------QQC 836 ++R+ L + K S E KE+E L ++NE L +QC Sbjct: 252 ------------AMMQQRIDRLALLNEKQAASPLEPKELEELRDKNESLTMRLHETLKQC 299 Query: 837 IQLN-EEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKA 895 L E+ + R +E+N +++++ E+A L+ L+D+ N+ E+ KA Sbjct: 300 QDLKTEKSQMDRKINQLSEENGDLSFK--LREFASHLQ---QLQDALNELTEEHS---KA 351 Query: 896 LNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLEL 955 E L Q ++ + S +DK L EK E+ + + +L Sbjct: 352 TQEWLEKQ----AQLEKELSAALQDKKC-----------------LEEKNEILQGKLSQL 390 Query: 956 SQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQ 1015 + LS L + Q+ GE+ ++++LKQE A + + +TQ Sbjct: 391 EEHLSQLQDNPPQEKGEVLGDVLQLETLKQE-------------------AATLAANNTQ 431 Query: 1016 VSSLLDGVVTMTSRGAEGSVSKVNKSFGEESK-----IMVEDKVSFENMTVGEESKQEQL 1070 + + ++ + T RG + + + EE K ++ + + S N++ +E ++ Sbjct: 432 LQARVE--MLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQAS 489 Query: 1071 ------ILDHLPSVTKE-SSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLV 1123 + + S+T E ++L AT ++ +L K +Q L ++ Q Sbjct: 490 QAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQ------- 542 Query: 1124 YSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQ-ETGDEGK 1182 +Q + + ++ ++ SLK++ E+++KE+ + + Q Q T E + Sbjct: 543 -----EQASQGLRHQVEQLSSSLKQK-----EQQLKEVAEKQEATRQDHAQQLATAAEER 592 Query: 1183 PLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPEL 1242 L + + A ++ + + L E L+ A D + ++ E EL Sbjct: 593 EASL---RERDAALKQLEALEKEKAAKL-EILQQQLQVANEARDSAQTSVTQAQREKAEL 648 Query: 1243 QDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEET 1302 +V++ Q + T + E ++ L+ +L + T+ ++ ++ L +E+ Sbjct: 649 SR---KVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQL-QEQL 704 Query: 1303 EFLSIHSQMT--NLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQN 1360 + L ++T +LE+ K + + + ++ + E E SL+ +++ KE E+ Sbjct: 705 QALKESLKVTKGSLEE----EKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEE 760 Query: 1361 YEAEIHCLQKRLQAVSESTVPPSLPVDSVVI--------TESDAQRTMYPGSCVKKNIDG 1412 A L+ RLQ + E+ + + + ES+ ++ + + ++ + Sbjct: 761 -RAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYED 819 Query: 1413 TIEFSGEFGVKEETNIVKLLE-----KQYQEQLEEEVAKVIVSMSIAFA-QQTELSRISG 1466 + + ++G + ++ L E +Q ++ +E+VA + + + QQ EL+ + Sbjct: 820 SQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQNELAELH- 878 Query: 1467 GKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGK 1526 + A A+ Q ++ KL+ D Q K + L ++ GE + Sbjct: 879 -------ANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGE--Q 929 Query: 1527 EILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQ 1586 + S + + D EE RQ + ++ +M+ + M NE Sbjct: 930 QETASRELVKEPARAGDRQPEWLEEQQG-------RQFCSTQAALQAMEREAEQMGNE-- 980 Query: 1587 LEDMRQELVR-QYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSIDN 1645 LE +R L+ Q Q+ ++ + R+ ER R + E+ R ++ +++++ Sbjct: 981 LERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNE 1040 Query: 1646 ENL------------VSERE-------------RVLLEELEALKQLSLAGREKLCCELRN 1680 + + ++E+E ++ELE L+Q +E+L + + Sbjct: 1041 QRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKE 1100 Query: 1681 SSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVK 1740 ++ + +E G E K + L + + + + A L+ LE + Sbjct: 1101 HASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADS------LERSLEAER 1154 Query: 1741 TTAAVEETIGRHVLGILDRSSKSQS-SASLIWRSEAEASVKSCVHEEHTRVTDESIPSYS 1799 + A ++ + G L+ ++ S S + ++ E + ++H++ DE + Sbjct: 1155 ASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVA 1214 Query: 1800 -GSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLL 1858 G ++ S + EE + L+++++ E+ + L++ S + Q E+L Sbjct: 1215 RGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKEL----KRLVMAESEKSQKLEERLR 1270 Query: 1859 EAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELS 1918 +ET+S A + L E ++EA + E LR+ L ++ E+L EL Sbjct: 1271 LLQAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQELK 1330 Query: 1919 KAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEE-RELLS 1977 + + E+ L Q++ + L ELL A + Q+L+AEQ ++ RE L Sbjct: 1331 AWQEKF--FQKEQALSTLQLEHTST--QALVSELLPAKHLCQQLQAEQAAAEKRHREELE 1386 Query: 1978 RQKEAMKAEAGPVEQQLLQETEKL-----------MKEKLEVQCQAEKV----------- 2015 + K+A AG + +LL+ +L +E+ Q +AEK Sbjct: 1387 QSKQA----AGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKK 1442 Query: 2016 --------------RDDLQKQVKALEIDV--EEQVSRFIELEQEKNTELMDLRQQNQALE 2059 R +L +Q +E+D E+ V + + T L +++++ Q+ Sbjct: 1443 AHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQREAQSTA 1502 Query: 2060 KQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLK 2119 ++LE M + + ER FQ+E QKL Q++ + FQ QT++VE+L+ L Sbjct: 1503 RELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQ---REQTKQVEELSKKLA 1559 Query: 2120 EKTDKCSELLLSK-EQLQRDIQERNEEIEKLEFRVRELEQALLVEDRKHFGAVEAKPELS 2178 + +D+ S++ K + +Q E +E ++L+ ++ EL+ L Sbjct: 1560 D-SDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQL------------------ 1600 Query: 2179 LEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQE 2238 +KE+ + + Q+E+ + + K ++ Q+L QL L++ Sbjct: 1601 ------------SQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLR--------SLEQ 1640 Query: 2239 LEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQ 2298 L++ENK + + E+LG ++++ + + + Q + ++ L QV Q Sbjct: 1641 LQKENKELRAEAERLGHELQQAGLKTKEAE--------QTCRHLTAQVRSLEAQVAHADQ 1692 Query: 2299 QLK 2301 QL+ Sbjct: 1693 QLR 1695 Score = 142 bits (358), Expect = 6e-33 Identities = 309/1485 (20%), Positives = 625/1485 (42%), Gaps = 191/1485 (12%) Query: 1834 EIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQ--EATE 1891 ++ EN +L + + +++L +A++E + EH+K TQ L +++ +K+ A + Sbjct: 315 QLSEENGDLSFKLRE-FASHLQQLQDALNELTE--EHSKATQEWLEKQAQLEKELSAALQ 371 Query: 1892 SLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQE 1951 KC EE E L + LS+ E + D + ++ ++ L+QE Sbjct: 372 DKKCLEEKNEILQGK----------LSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQE 421 Query: 1952 LLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLM--------- 2002 + +L+A + ++ ER +Q+ + AE G E++ Q + + Sbjct: 422 AATLAANNTQLQARVEMLETER---GQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNL 478 Query: 2003 ---KEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALE 2059 KE+LE QA R L QV +L +++ Q+++ EL L+QQ + + Sbjct: 479 SQAKEELEQASQAHGAR--LTAQVASLT----SELTTLNATIQQQDQELAGLKQQAKEKQ 532 Query: 2060 KQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLK 2119 QL + + ++ + H+ + +++ EQQLK V Q + Sbjct: 533 AQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEAT--------------- 577 Query: 2120 EKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVEDRKHFGAVEAKPELSL 2179 + D +L + E+ + ++ER+ +++LE +E L + ++ A EA+ Sbjct: 578 -RQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQT 636 Query: 2180 EV-QLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQE 2238 V Q Q E+ + RK +E L+ +E R+E +V +L +QL +++++T + + Sbjct: 637 SVTQAQREKAELSRKVEE---LQACVETARQEQHEAQAQVAELELQLRSEQQKATEK-ER 692 Query: 2239 LEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQ 2298 + QE KD +++ A+KES ++ + A ++E++ I +L + L + Sbjct: 693 VAQE----KDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVE 748 Query: 2299 QLKITTDNKVIEEKNELIRDLETQIECL--------------MSDQECVKRNREEEIEQL 2344 Q K + K +EE+ + LE +++ L +++ + E E EQL Sbjct: 749 QHK--RERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQL 806 Query: 2345 -------NEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETA 2397 E E QQE A G +L EE + + +L + +E E Sbjct: 807 VKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQ 866 Query: 2398 -----NEEMTFMKNV------LKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVA 2446 NE N+ ++E + +L +L +L+ + + K + E V A Sbjct: 867 ISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKA 926 Query: 2447 IDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLE 2506 + EL ++ ++ + Q + EE + + L +E E Sbjct: 927 GEQQETASREL----VKEPARAGDRQPEW--LEEQQGRQFCSTQAALQAMEREAEQMGNE 980 Query: 2507 LTQCYKQIKDMQEQGQFETEMLQKKIVNLQK---------IVEEKVAAALVSQIQLEAVQ 2557 L + + + Q Q Q E ++++ L + +E+ A L ++Q + Sbjct: 981 LERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNE 1040 Query: 2558 EYAKFCQDNQTIS---SEPERTNIQNLNQLREDELGS--DISALTLRISELESQVVEMH- 2611 + +F + ++ +E E + Q L +LR E ++ L + +L+ Q+ + Sbjct: 1041 QRVEFATLQEALAHALTEKEGKD-QELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEK 1099 Query: 2612 ------------------TSLILEKEQVEIA--EKNVLEKEKKLLELQKLLEGNEKKQRE 2651 T LE + E++ E+ +++++ L++ LE + E Sbjct: 1100 EHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAE 1159 Query: 2652 KEKKRSPQDVEVLKTTTELFHSNEE-SGFFNELEALRAESVATKAELASYKEKAEKLQEE 2710 ++ ++ + EL HS + EL A R + +K + + ++E Sbjct: 1160 RDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQE 1219 Query: 2711 LLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLSKSI 2770 K + ++SL++++S + + E + + L++ E ++S+K + E L + +++ Sbjct: 1220 AERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQK--LEERLRLLQAETA 1277 Query: 2771 ASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTEIISQFTEKIEKM-QELHAA 2829 ++ + S+ + Q L + A Q +SE + + ++ E+ E++ QEL A Sbjct: 1278 SNSARAAERSSALREEVQSLREEAEKQ-----RVASENLRQELTSQAERAEELGQELKAW 1332 Query: 2830 EILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQT 2889 + + TL+ EH + Q L E K + Q L++++ ++ E H + + Sbjct: 1333 QEKFFQKEQA--LSTLQLEH-TSTQALVSELLPAKHLCQQLQAEQAAA--EKRHREELEQ 1387 Query: 2890 REICSSD-------SGSDWGQGIYLTH--SQGFDIASEGRGEESESATD-SFPKKIKGLL 2939 + + + + G+ I L ++ A + R E++ A S KK GLL Sbjct: 1388 SKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLL 1447 Query: 2940 RAVHNEGMQVLSLTESPYSDGEDHSI-QQVSEPWLEE-RKAYINTISSLK-DLITKM-QL 2995 A N G+ GE ++ +Q E L++ R+ Y+ +++++ D T++ ++ Sbjct: 1448 -AEENRGL------------GERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEV 1494 Query: 2996 QREAEVYDSSQSHESFSDWRGELLLALQ--QVFLEERSVLLAAF-RTELTALGTTDAVGL 3052 QREA+ + + + + G + L+ Q F EER L A + E+ T V Sbjct: 1495 QREAQS-TARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEE 1553 Query: 3053 LNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITL-KREQESE--KP 3109 L+ + Q ++ +Q S E Q L AQ+N + L ++EQ +E K Sbjct: 1554 LSKKLADSDQASKVQQQKLKAVQAQGGESQ-QEAQRLQAQLNELQAQLSQKEQAAEHYKL 1612 Query: 3110 SQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELET 3169 E + + K+ Q E+Q +L S++ E +E + + + EL+ +TK E E Sbjct: 1613 QMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHELQQAGLKTK-EAEQ 1671 Query: 3170 TLKAQHKHLKELEAFRLEVKDKTDEVHLLND-TLASEQKKSRELQ 3213 T + ++ LEA +V ++ L +A++ KSRE Q Sbjct: 1672 TCRHLTAQVRSLEA---QVAHADQQLRDLGKFQVATDALKSREPQ 1713 Score = 142 bits (357), Expect = 8e-33 Identities = 254/1280 (19%), Positives = 520/1280 (40%), Gaps = 161/1280 (12%) Query: 147 EQGAQDSPTHLEMMESELAGKQHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGI 206 EQ +Q +E + S L K+ +++E+ + E R + + +E EA++++RD Sbjct: 543 EQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAA 602 Query: 207 ITQLTA--------------NLQQARREKDETMREFLELTEQSQKLQIQFQQLQAS-ETL 251 + QL A LQ A +D + + +L + ++LQA ET Sbjct: 603 LKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETA 662 Query: 252 RNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYE-- 309 R H + A + + + Q+ + QQ+ E++ + ++ K+ Q+ L+E +KV + Sbjct: 663 RQEQHEA-QAQVAELELQLRSEQQKATEKERVAQE----KDQLQEQLQALKESLKVTKGS 717 Query: 310 MEQDKKVENSNKEEIQEKETIIEELNTK---IIEEEKK-TLELKDKLTTADKLLGELQEQ 365 +E++K+ + ++E++ I EL + ++E+ K+ EL+++ L LQ+ Sbjct: 718 LEEEKR---RAADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQL 774 Query: 366 IVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQE 425 E + ++ EL + + + E +QL+ V ++R ++DSQ Sbjct: 775 GEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRER-YEDSQ------------ 821 Query: 426 TQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNE 485 Q A+ M+ +Q++ +K+E + +++E K + G + S+S + ++ Sbjct: 822 ------QEEAQYGAMFQEQLMTLKEECEKARQ-ELQEAKEKVAG-----IESHSELQISR 869 Query: 486 DQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQ 545 Q +L + N L L + E++ Q+ L ++LS +E++ Sbjct: 870 QQNELAELHAN---------------LARALQQVQEKEVRAQK----LADDLSTLQEKMA 910 Query: 546 RARQTIAEQESKLNEAHKSLSTV-EDLKAEIVSASESRKE-LELKHEAEVTNYKIKLEML 603 + +A E+ + +A + T +L E A + + E LE + + + + L+ + Sbjct: 911 ATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAM 970 Query: 604 EKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEK--------L 655 E+E AE ELERLR L+ S ++ + + R+ E+ L Sbjct: 971 ERE--------AEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLAL 1022 Query: 656 KDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSE 715 + + ++ NE + T+Q + +T++ E++KL+ L+ + + + E Sbjct: 1023 EKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQI-KELE 1081 Query: 716 EMTLQINELQKEIEILRQEEKEKGTLEQE-----------VQELQLKTELLEKQMKEKEN 764 E+ + +L++++ +E + E ++ L+ + LE+Q ++++ Sbjct: 1082 ELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQE 1141 Query: 765 DLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEI 824 LEAE + + LE + +QE ++ + + + +++ Sbjct: 1142 QADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQD 1201 Query: 825 LIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEV-NYQELQEEYACLLKVKDDLEDSKN 883 + ++ K Q + +E E++ + S E+ + N Q L++E + + +S+ Sbjct: 1202 HSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEK 1261 Query: 884 KQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELME 943 Q+LE +L+ L E N +SS E+ + E E V ++ L + Sbjct: 1262 SQKLE--ERLRLLQAE---TASNSARAAERSSALREEVQSLREEAEKQRVASEN---LRQ 1313 Query: 944 KLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEE---VKSLKQEKEQVSLRCRELEII 1000 +L EL Q L E+ QK +S L E ++L E C++L+ Sbjct: 1314 ELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQ-- 1371 Query: 1001 INHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMT 1060 AE + + S G G + + + GE I + KV+ + T Sbjct: 1372 AEQAAAEKRHREELEQSKQAAG-------GLRAELLRAQRELGE--LIPLRQKVAEQERT 1422 Query: 1061 VGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNV----LKSEQNDLRLQMEAQ 1116 + ++ + L + K L A EN L + N+ L+ E + R + + Sbjct: 1423 AQQLRAEKASYAEQLSMLKKAHGLLA---EENRGLGERANLGRQFLEVELDQAREKYVQE 1479 Query: 1117 RICLSLVYSTHVDQVR----------EYMENEKDKALCSLKEELIFAQEEKIKELQKIHQ 1166 + T + +V+ E M + + A + EE QEE+ K ++ Q Sbjct: 1480 LAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQ 1539 Query: 1167 LEL----QTMKTQE------TGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTP 1216 LE+ QT + +E D+ + K +A E Q L + L E Sbjct: 1540 LEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQ 1599 Query: 1217 ALKCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTR 1276 + E AE + + + D + Q + Q+ QE + + L ++ +E +L R Sbjct: 1600 LSQKEQAAEHYKLQMEKAKTHYDAKKQ----QNQELQEQLRS-LEQLQKENKELRAEAER 1654 Query: 1277 LSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKL 1336 L Q G+K + E+ + S+ +Q+ + D + K D K++ Sbjct: 1655 LGH--ELQQAGLKTKEAEQTCRHLTAQVRSLEAQVAH-ADQQLRDLGKFQVATDALKSRE 1711 Query: 1337 EEQVQELESLISSLQQQLKE 1356 + +L+ I SL +E Sbjct: 1712 PQAKPQLDLSIDSLDLSCEE 1731 Score = 138 bits (348), Expect = 9e-32 Identities = 289/1400 (20%), Positives = 554/1400 (39%), Gaps = 189/1400 (13%) Query: 134 LREEEFGVDDSYSEQGAQDSPTHLEMME--SELAGKQHEIEELNRELEEMRVTYGTEGLQ 191 L+ E+ +D ++ ++ ++ E S L Q + EL E + + + Q Sbjct: 302 LKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQLQDALNELTEEHSKATQEWLEKQAQ 361 Query: 192 QLQEFEAAIKQR----------DGIITQLTANLQQAR----REKDETMREFLELTEQSQK 237 +E AA++ + G ++QL +L Q + +EK E + + L+L Q+ Sbjct: 362 LEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQE 421 Query: 238 ---LQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDF 294 L QLQA + + A LL + +QQL L+ D Q + Sbjct: 422 AATLAANNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQQLSS---LITDLQSSISNL 478 Query: 295 TMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIE---ELNTKIIEEEKKTLELKDK 351 + L++ + + +V + E TI + EL + ++K +L Sbjct: 479 SQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQT 538 Query: 352 LTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKD 411 L ++ L+ Q+ Q + +K + +L +K+ + ++ Q + T E ++ + ++ Sbjct: 539 LQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRE 598 Query: 412 SQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEM 471 ++ +E+E KLE L+ +L Q+ ++ + + Q + K ++ Sbjct: 599 RDAALKQLEALEKEKAAKLEILQQQL------QVANEARDSAQTSVTQAQREKAELSRKV 652 Query: 472 ENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLE 531 E L++ E VA EL ++ + QK KE + +EK LQ QL+ Sbjct: 653 EE-LQACVETARQEQHEAQAQVAELELQLR---SEQQKATEKER---VAQEKDQLQEQLQ 705 Query: 532 DLVEELSFSR----EQIQRARQTIAEQESKLNEAH-KSLSTVEDLKAEIVSASE---SRK 583 L E L ++ E+ +RA + EQ+ ++E ++ S VE K E E RK Sbjct: 706 ALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRK 765 Query: 584 ELELK-------HEAEVTNYKIKL--------------EMLEKEKNAVLDRMAESQEAEL 622 LE + H+AE + +L E L KE A +R +SQ+ E Sbjct: 766 GLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEE- 824 Query: 623 ERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNL-GI--HYKQQIDGLQNEMS---- 675 Q +E+L LKE+ E + R +++ K+ + GI H + QI QNE++ Sbjct: 825 ----AQYGAMFQEQLMTLKEECE-KARQELQEAKEKVAGIESHSELQISRQQNELAELHA 879 Query: 676 ----------QKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQ 725 +K Q D+L T Q ++ ++ L ++LV E+ EL Sbjct: 880 NLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARL-ETLVRKAGEQQETASRELV 938 Query: 726 KE--------IEILRQEEKEK--------GTLEQEVQELQLKTELLEKQMKEKENDLQEK 769 KE E L +++ + +E+E +++ + E L + E + QE+ Sbjct: 939 KEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEE 998 Query: 770 FAQLEAENSILKDEK----------KTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWE 819 Q E E + L E+ K L++ + E+ + +++ ++ E Sbjct: 999 RGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTE 1058 Query: 820 KEIE------------ILIEENEDLKQQCIQLNEEI---EKQRNTFSFAEKNFEVNYQEL 864 KE + I+E E+L+Q QL E++ EK+ + S A+ + Sbjct: 1059 KEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPT 1118 Query: 865 QEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFV 924 + L LE KQ+ + S ++L E + + ++ +E + Sbjct: 1119 GPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQEL 1178 Query: 925 AETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLK 984 + +++ K++ + + E +++ ++ ++K+ IS L EEV L Sbjct: 1179 GHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILN 1238 Query: 985 QEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGE 1044 ++ + +EL+ ++ +E Q + ++ L + ++R AE S + E Sbjct: 1239 RQVLEKEGESKELKRLV-MAESEKSQKLEERLRLLQAETASNSARAAERS-----SALRE 1292 Query: 1045 ESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKS 1104 E + + E+ E V E+ +++L + L+A Q K ++ L+ L+ Sbjct: 1293 EVQSLREEA---EKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQK-EQALSTLQL 1348 Query: 1105 EQNDLRL----QMEAQRICLSLVYSTHVDQVREYMENEKDK-ALCSLKEELIFAQEE--- 1156 E + + A+ +C L + R E E+ K A L+ EL+ AQ E Sbjct: 1349 EHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGE 1408 Query: 1157 ------KIKELQK-IHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECS---YFLQTL 1206 K+ E ++ QL + E K H L+ + + + E + FL+ Sbjct: 1409 LIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVE 1468 Query: 1207 CSVLGEYYT---PALKCEVNAEDKENSGDYISENEDPELQDYRY---------EVQDFQE 1254 E Y A++ + E + S + E+ +Y E Q FQE Sbjct: 1469 LDQAREKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQE 1528 Query: 1255 NMHTLL-------------NKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGE--ENLPK 1299 L K EE +K L + SK+ Q+ ++ + GE + + Sbjct: 1529 ERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQR 1588 Query: 1300 EETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQ 1359 + + + +Q++ E ++K ++ + K ++Q QEL+ + SL+Q KE ++ Sbjct: 1589 LQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAK-KQQNQELQEQLRSLEQLQKENKE 1647 Query: 1360 NYEAEIHCLQKRLQAVSEST 1379 AE L LQ T Sbjct: 1648 -LRAEAERLGHELQQAGLKT 1666 Score = 132 bits (333), Expect = 5e-30 Identities = 330/1674 (19%), Positives = 665/1674 (39%), Gaps = 244/1674 (14%) Query: 350 DKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNH 409 D L T + L++Q+ + ++LEL +++ + +I + ++ L N Sbjct: 207 DILQTPQFQMRRLKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLALLNE 266 Query: 410 KDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKG 469 K Q + + + +E + K E L L E +Q +K E + M + + G Sbjct: 267 K--QAASPLEPKELEELRDKNESLTMRLHETL-KQCQDLKTE--KSQMDRKINQLSEENG 321 Query: 470 EMENALRSYSNITVNEDQIKLMNVAINELNIK----LQDTNSQKEKLKEELGLILEEKCA 525 ++ LR +++ ++ + A+NEL + Q+ ++ +L++EL L++K Sbjct: 322 DLSFKLREFAS------HLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKC 375 Query: 526 LQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKEL 585 L+ + E L +LS E + + + +++ E + +E LK E + + + +L Sbjct: 376 LEEKNEILQGKLSQLEEHLSQLQDNPPQEK---GEVLGDVLQLETLKQEAATLAANNTQL 432 Query: 586 ELKHEAEVTNYKIKLEMLEKEKNAVLDR-MAESQEAELERLRTQLLFSHEEELSKLKEDL 644 + + E ++ E ++E + +R E ++ +L L T L S LS+ KE+L Sbjct: 433 QARVE------MLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQ-SSISNLSQAKEEL 485 Query: 645 EIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLI-------TKQNQLIL 697 E + + G Q+ L +E++ T+Q + L KQ QL Sbjct: 486 EQASQAH--------GARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQ 537 Query: 698 EISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEK 757 + + + Q L + E+++ + QKE ++ EK++ T + Q+L E E Sbjct: 538 TLQQQEQASQGL-RHQVEQLSSSLK--QKEQQLKEVAEKQEATRQDHAQQLATAAEEREA 594 Query: 758 QMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSV 817 ++E++ L+ QLEA + + L+ L++ + + + K++ S Sbjct: 595 SLRERDAALK----QLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSR 650 Query: 818 WEKEIEILIE----ENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACL-- 871 +E++ +E E + + Q +L ++ ++ + E+ + +LQE+ L Sbjct: 651 KVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQ-EKDQLQEQLQALKE 709 Query: 872 -LKV-KDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDED----KTFVA 925 LKV K LE+ K + + + + ++E R K + +E+ K A Sbjct: 710 SLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEA 769 Query: 926 ETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQ 985 ++GE + +T EV +RE E + +Q E++ E + +Q Sbjct: 770 RLQQLGEAHQAET-------EVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQ 822 Query: 986 EKEQVSLRCRELEIIIN---HNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSF 1042 E+ Q +E + + + +Q +V+ + SR + +++++ + Sbjct: 823 EEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISR-QQNELAELHANL 881 Query: 1043 GEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRAT---QPSENDKLQKEL 1099 + + E +V + + + QE++ E+ +R Q + + +L KE Sbjct: 882 ARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEP 941 Query: 1100 NVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIK 1159 Q + + + ++ C + +++ E M NE ++ +L E QEE+ + Sbjct: 942 ARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEERGQ 1001 Query: 1160 ELQKIHQLELQTMKTQETGDEGKPLHL-------LIGKLQKAVSEECSYFLQTLCSVLGE 1212 + +++ +L TQE G L L L +LQ A++E+ F TL L Sbjct: 1002 QEREVARL------TQERGRAQADLALEKAARAELEMRLQNALNEQRVEF-ATLQEALAH 1054 Query: 1213 YYTPALKCEVNAEDKENSG-DYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLL 1271 T E +D+E + + + EL++ R V+ +E L K +E+ Sbjct: 1055 ALT-----EKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQ----LAKKEKEHASGS 1105 Query: 1272 VLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTNLE-DIDVNHKSKLSSLQD 1330 Q+ + + G KLE + K E + Q +LE ++ S+ Sbjct: 1106 GAQSEAA--GRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSA 1163 Query: 1331 LE--KTKLEEQVQEL---ESLISSLQQQL----------KETEQNYEAEIHCLQKRLQAV 1375 LE + +LEE+ QEL +S ++S Q++L + E ++A++ + R +A Sbjct: 1164 LETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQV--ARGRQEAE 1221 Query: 1376 SESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQ 1435 ++++ SL + ++ +E GE +E + + E + Sbjct: 1222 RKNSLISSLEEEVSILNRQ------------------VLEKEGE---SKELKRLVMAESE 1260 Query: 1436 YQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQ 1495 ++LEE + + Q E + N+A + + + ++E E Q Sbjct: 1261 KSQKLEERLRLL----------QAETA------SNSARAAERSSALREEVQSLREEAEKQ 1304 Query: 1496 DQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEMFSK 1555 ++E ++ E G+E+ E+ F K Sbjct: 1305 --------RVASENLRQELTSQAERAEELGQEL-----------------KAWQEKFFQK 1339 Query: 1556 DKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQ 1615 ++ Q H S Q +++E + L +Q Q Q A E + H + Sbjct: 1340 EQALSTLQLEH---------TSTQALVSELL---PAKHLCQQLQAEQAAAE---KRHREE 1384 Query: 1616 MERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLC 1675 +E+ ++ L+ E+ R R+L + I V+E+ER ++L A ++ S A + + Sbjct: 1385 LEQSKQAAGGLRAELLRAQRELGE--LIPLRQKVAEQERT-AQQLRA-EKASYAEQLSML 1440 Query: 1676 CELRNSSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKIL 1735 + + G + + Q F E ELD+ E E+ + A RL ++ Sbjct: 1441 KKAHGLLAEENRGLGERANLGRQ-FLEVELDQAREKYVQELAA----VRADAETRLAEVQ 1495 Query: 1736 LEVVKTTAAVEETIGRH---VLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTD 1792 E T +E ++ + +L+ + Q + A+ E T+ + Sbjct: 1496 REAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQ---KLTAQVEQLEVFQREQTKQVE 1552 Query: 1793 ESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQA 1852 E + SD SKV + Q+L G E E + RLQA Sbjct: 1553 ELSKKLADSDQA-------SKVQQ------QKLKAVQAQGGESQQE--------AQRLQA 1591 Query: 1853 AVEKLLEAISETSSQLEHAKVTQTELMRESF----RQKQEATESLKCQEELRERLHEESR 1908 + +L +S+ EH K+ Q E + + +Q QE E L+ E+L++ E Sbjct: 1592 QLNELQAQLSQKEQAAEHYKL-QMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRA 1650 Query: 1909 AREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQEL 1962 E+L EL +A G ++ E+ + T + LE ++ A +L++L Sbjct: 1651 EAERLGHELQQA-----GLKTKEA--EQTCRHLTAQVRSLEAQVAHADQQLRDL 1697 Score = 77.0 bits (188), Expect = 3e-13 Identities = 129/604 (21%), Positives = 252/604 (41%), Gaps = 83/604 (13%) Query: 3120 QKQSQMLEMQVELSSMKDR-------ATELQEQLSSEKMVVAELKSELAQTKL---ELET 3169 +++ + LE+Q SS A+ + + L + + + LK +LA + ELE Sbjct: 176 KREIRFLELQKVASSSSGNNFLSGSPASPMGDILQTPQFQMRRLKKQLADERSNRDELEL 235 Query: 3170 TLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEER 3229 L K L E +A ++ + D + LLN+ A+ + +EL+ +K ++ R E Sbjct: 236 ELAENRKLLTEKDAQIAMMQQRIDRLALLNEKQAASPLEPKELEELRDKNESLTMRLHET 295 Query: 3230 DKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDA--QLSEEQGRN 3287 K + +DLK + Q + ++N L E+ L + ++ + L DA +L+EE + Sbjct: 296 LK-QCQDLK---TEKSQMDRKINQLSEENGDLSFKLREFASHLQQLQDALNELTEEHSKA 351 Query: 3288 ----LELQVLLESEKVRIREMSSTLDREREL----HAQLQSSDGTGQSRPPLPSEDLLKE 3339 LE Q LE E + L+ + E+ +QL+ Q PP ++L + Sbjct: 352 TQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGD 411 Query: 3340 LQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHE 3399 + + K N T+ LQ R +M + + ++ + + E +K+ + Sbjct: 412 VLQLETLKQEAATLAANNTQ------LQARVEMLETERGQQEAKLLAERGHFEEEKQ--Q 463 Query: 3400 LQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELEREEKRESRRILYQ---NL 3456 L S + DLQ + Q K+ELE+ + R+ Q Sbjct: 464 LSSLITDLQSSISNLSQ-------------------AKEELEQASQAHGARLTAQVASLT 504 Query: 3457 NEPTTWSLTSDRTRNWVLQQKIEGETKESNYAK-LIEMNGGGTGCNHELEMI-------R 3508 +E TT + T + + K + + K++ A+ L + G H++E + Sbjct: 505 SELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKE 564 Query: 3509 QKLQCVASKLQVLPQKASERLQFETADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVS 3568 Q+L+ VA K + Q ++ Q TA +E ++E D + QL+ L ++ + ++ Sbjct: 565 QQLKEVAEKQEATRQDHAQ--QLATAAEEREASLRER-DAALKQLEALEKEKAAKLEILQ 621 Query: 3569 PS--------TSCGSLTERLLRQNAELTGHISQL-------TEEKNDLRNMVMKLEEQIR 3613 S + + R+ AEL+ + +L +E+++ + V +LE Q+R Sbjct: 622 QQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLR 681 Query: 3614 WYRQTGAGRDNSSRFSLNGGANIEAIIAS---EKEVWNREKLTLQKSLKRAEAEVYKLKA 3670 +Q ++ ++ ++A+ S K EK +L+ + + +LKA Sbjct: 682 SEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKA 741 Query: 3671 ELRN 3674 E R+ Sbjct: 742 ETRS 745 Score = 72.8 bits (177), Expect = 6e-12 Identities = 137/650 (21%), Positives = 270/650 (41%), Gaps = 96/650 (14%) Query: 3066 EYQAAMECLQKADRRSLLSEIQALHAQMNG----RKITLKREQESEKPSQELLEYNIQQK 3121 E+ + ++ LQ A L+E+ H++ ++ L++E + ++ LE + Sbjct: 329 EFASHLQQLQDA-----LNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEIL 383 Query: 3122 QSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELA---------QTKLELETTLK 3172 Q ++ +++ LS ++D + + ++ + + + LK E A Q ++E+ T + Sbjct: 384 QGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETER 443 Query: 3173 AQH--KHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERD 3230 Q K L E F E + + + L ++++ + EL+ A + A+L Sbjct: 444 GQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASL 503 Query: 3231 KEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLE- 3289 EL L +++ Q Q L KQ E Q ++ +Q + Q S+ +E Sbjct: 504 TSELTTLNATIQQQDQE-------LAGLKQQAKEKQAQL-AQTLQQQEQASQGLRHQVEQ 555 Query: 3290 LQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHS 3349 L L+ ++ +++E++ + R+ HAQ ++ +E + L E+ + Sbjct: 556 LSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAA--------------EEREASLRERDA 601 Query: 3350 RIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQR 3409 + +L EK K L+ QQ QV + + Q + T+ Q++ EL KVE+LQ Sbjct: 602 ALKQL-EALEKEKAAKLEILQQQ---LQVANEARDSAQTSVTQAQREKAELSRKVEELQA 657 Query: 3410 QLEEKRQ-------QVYKLDLEGQRLQGIMQEFQKQELEREEKRESRRILYQNLNEPTTW 3462 +E RQ QV +L+L+ + Q E ++ E+++ +E + L ++L + T Sbjct: 658 CVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESL-KVTKG 716 Query: 3463 SLTSDRTR---------NWVLQQKIEG----ETKESNYAKLIEMNGGGTGCNHELEMIRQ 3509 SL ++ R + + K E E + +L E G G L+ + + Sbjct: 717 SLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGE 776 Query: 3510 KLQCVASKLQVLPQKASERLQFE-TADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVS 3568 Q ++ +VL ++ +E + + TA+ E ++ + E+ ++ Q EE + Sbjct: 777 AHQ---AETEVLRRELAEAMAAQHTAESE----CEQLVKEVAAWRERYEDSQQEEAQYGA 829 Query: 3569 PSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRF 3628 E+L+ E +L E K + + E QI R + Sbjct: 830 ------MFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQI--------SRQQNELA 875 Query: 3629 SLNGGANIEAIIASEKEVWNREKL-----TLQKSLKRAEAEVYKLKAELR 3673 L+ EKEV +KL TLQ+ + EV +L+ +R Sbjct: 876 ELHANLARALQQVQEKEV-RAQKLADDLSTLQEKMAATSKEVARLETLVR 924 Score = 70.9 bits (172), Expect = 2e-11 Identities = 109/535 (20%), Positives = 231/535 (43%), Gaps = 62/535 (11%) Query: 3100 LKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELK-S 3158 LK++ E+ +++ LE + + + + E +++ M+ R L L +EK + L+ Sbjct: 219 LKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLA--LLNEKQAASPLEPK 276 Query: 3159 ELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEK 3218 EL + + + E+ H+ LK+ + + E +++ L++ K RE L++ Sbjct: 277 ELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQ 336 Query: 3219 EKAKLGR-SEERDK--EELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRML 3275 + L +EE K +E + + LE + LQ LE++ ++L ++E Sbjct: 337 LQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQ 396 Query: 3276 YDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSD-GTGQSRPPLPSE 3334 +E+G L + LE+ K +E ++ +L A+++ + GQ L +E Sbjct: 397 LQDNPPQEKGEVLGDVLQLETLK---QEAATLAANNTQLQARVEMLETERGQQEAKLLAE 453 Query: 3335 DLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVH--RKTLQ-------- 3384 + EE+ ++ L+ + + + Q ++++E+ Q H R T Q Sbjct: 454 ------RGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSEL 507 Query: 3385 -----TEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQE 3439 T Q+ + E + + K L + L+++ Q L + ++L +++ ++Q Sbjct: 508 TTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQL 567 Query: 3440 LEREEKRESRRILY-QNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGT 3498 E EK+E+ R + Q L S R R+ L+Q +E KE Sbjct: 568 KEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQ-LEALEKEK------------- 613 Query: 3499 GCNHELEMIRQKLQCVASKLQVLPQKASERLQFETADDEDFIWVQENIDEIILQLQKLTG 3558 +LE+++Q+LQ VA++ + Q + + Q E A+ + ++E+ ++ Sbjct: 614 --AAKLEILQQQLQ-VANEARDSAQTSVTQAQREKAE------LSRKVEELQACVETARQ 664 Query: 3559 QQGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKLEEQIR 3613 +Q E + V+ E LR + ++ +EK+ L+ + L+E ++ Sbjct: 665 EQHEAQAQVAE-------LELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLK 712 >gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo sapiens] Length = 1870 Score = 167 bits (422), Expect = 2e-40 Identities = 264/1279 (20%), Positives = 560/1279 (43%), Gaps = 194/1279 (15%) Query: 183 VTYGTEGLQQLQEFEAAIKQRDGI---ITQLTANLQQARREKDETMREFLELTEQSQKLQ 239 VT+ E + LQ E ++ I + + +L++ E+DE +EL+E+ L Sbjct: 163 VTHNQENVFDLQWMEVTDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLH 222 Query: 240 IQFQQLQASET-------LRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKE 292 ++++ R + + +L AK +I +Q+LEE+ L D +++ E Sbjct: 223 FLPHASSSAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELE 282 Query: 293 DFTMQISFLQEK----------IKVYEMEQDK------KVENSNKEEIQEKETI------ 330 +++ LQ++ ++Y E D +V+ E + KE + Sbjct: 283 QMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFY 342 Query: 331 ---IEEL--NTKIIEEEKKTLE--LKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNS 383 +EEL + +++ E K LE L+ +DK L EL+++ +Q ++ +M++E Sbjct: 343 KARVEELKEDNQVLLETKTMLEDQLEGTRARSDK-LHELEKENLQLKAKLHDMEME---- 397 Query: 384 KQKERQSSEEIKQLMGTVEELQKRNHKDS---QFETDIVQRMEQETQRKLEQLRAELDEM 440 + +R+ EE+ + T+E QK++ +S +E + + R + ++ + L E++E+ Sbjct: 398 RDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNEL 457 Query: 441 YGQQIVQMKQELIRQHMAQ-MEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELN 499 ++++++ E Q + + +EE++T NA + N+ K + + NE+ Sbjct: 458 TSSRLLKLEME--NQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIV 515 Query: 500 IKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLN 559 + Q + + K+ +++EK L++ +E L RE +R + + ++ LN Sbjct: 516 QEKQSLQNCQNLSKD----LMKEKAQLEKTIETL-------RENSERQIKILEQENEHLN 564 Query: 560 EAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRM----- 614 + SL + AE + KE ++ HE+ + KL +E EK + + Sbjct: 565 QTVSSLRQRSQISAE-ARVKDIEKENKILHES-IKETSSKLSKIEFEKRQIKKELEHYKE 622 Query: 615 ----AESQEAELERL--RTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQID 668 AE E EL L +LL L E +E + N E ++N + K+ +D Sbjct: 623 KGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKL--KKTLD 680 Query: 669 GLQNEMSQ----KIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINEL 724 +N Q + E Q +++NL ++N L+ + +K Q L N +E+ + +L Sbjct: 681 SFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLEN---KELESEKEQL 737 Query: 725 QKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEK 784 +K +E+L+ K+ LE Q L ++ + L+K ++ +Q QLE+E L+ E Sbjct: 738 KKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQ----QLESELQDLEMEN 793 Query: 785 KTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIE 844 +TL+ K+ + + K +E L +EN+ L+Q+ QL ++ Sbjct: 794 QTLQ---------------------KNLEELKISSKRLEQLEKENKSLEQETSQLEKD-- 830 Query: 845 KQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQR 904 +K E + L+++ ++KD + N + + + K L++E+ + + Sbjct: 831 ---------KKQLEKENKRLRQQ----AEIKDTTLEENNVKIGNLEKENKTLSKEIGIYK 877 Query: 905 INPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSE 964 + V++K +EK+ EL+++ + + + L + L +SE Sbjct: 878 --ESCVRLKE-------------------LEKENKELVKRATIDIKTLVTLREDL--VSE 914 Query: 965 QLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVV 1024 +LK + +N +++ L E E++ L +E + + + + ++++ S L + Sbjct: 915 KLKTQQ-----MNNDLEKLTHELEKIGLN-KERLLHDEQSTDDRYKLLESKLESTLKKSL 968 Query: 1025 TMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSL 1084 + +++ +S ++ E K +N ++ + E+ ++ P ++ E + Sbjct: 969 EIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNK 1028 Query: 1085 --RATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKA 1142 R +Q + + L+ + +++ E+N+ LQ E Q + T + Q+ E N Sbjct: 1029 WERESQETTRELLKVKDRLIEVERNNATLQAEKQAL------KTQLKQL-ETQNNNLQAQ 1081 Query: 1143 LCSLKEELIFAQEEK--IKELQKIHQLELQTMKTQETGDEGKPLHLLIGKL-----QKAV 1195 + +L+ + + QE+ ++ Q+E T+ +Q T + LLI + ++V Sbjct: 1082 ILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESV 1141 Query: 1196 SEECSYFLQTLCSVLGEYYTPALKCEVNAEDKEN----SGDYISENEDPELQDYRYEVQD 1251 +E S++ ++ L E A + E+ G S +++ E+ E +D Sbjct: 1142 IKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEV-----EHRD 1196 Query: 1252 FQENMHTLLNK--VTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHS 1309 ++ + LL + E+ K+L ++ + + + + E+ + L E +S Sbjct: 1197 LEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEY--KKLCGENDRLNHTYS 1254 Query: 1310 Q-MTNLEDIDVNHKSKLSSLQD--LEKTKLE-------EQVQELESLISSLQQQ---LKE 1356 Q + E + +HK+ S L + LE+T+LE EQ Q+L+ + L Q L + Sbjct: 1255 QLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQ 1314 Query: 1357 TEQNYEAEIHCLQKRLQAV 1375 + N E E L ++Q + Sbjct: 1315 LKGNLEEENRHLLDQIQTL 1333 Score = 152 bits (385), Expect = 5e-36 Identities = 278/1275 (21%), Positives = 558/1275 (43%), Gaps = 224/1275 (17%) Query: 152 DSPTHLEMMESELAGKQHEIEELNRELEEMRVTYGTEGL----QQLQEFEAAIKQRDGII 207 +S HL + ELA + +I L +ELEE TE L Q+L++ E +K+ Sbjct: 244 ESRQHLSV---ELADAKAKIRRLRQELEEK-----TEQLLDCKQELEQMEIELKRLQQEN 295 Query: 208 TQLTANLQQARREKDETMREFLELTEQSQKLQIQFQQLQASETLRN-STHSSTAADLLQA 266 L ++ + AR +DE + E + KL+ + + + E L + + + +L + Sbjct: 296 MNLLSDARSARMYRDE-LDALREKAVRVDKLESEVSRYK--ERLHDIEFYKARVEELKED 352 Query: 267 KQQILTHQQQLEEQDHLLEDYQKKKEDF-TMQISFLQEKIKVYEMEQDKKVENSNKEEIQ 325 Q +L + LE+Q LE + + + ++ LQ K K+++ME ++ ++ EE+ Sbjct: 353 NQVLLETKTMLEDQ---LEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELM 409 Query: 326 EKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKN---MKLELTN 382 E+ +E + ++E ++++ +L Q+ + + E+ + +KLE+ N Sbjct: 410 EENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMEN 469 Query: 383 SKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYG 442 + ++ +++L TV+ ++ K + +ME+E QR +++ E+ Sbjct: 470 -----QSLTKTVEELRTTVDSVEGNASK--------ILKMEKENQRLSKKV-----EILE 511 Query: 443 QQIVQMKQELIRQHMAQMEEMKTRHKGEMENALR-----SYSNITVNEDQIKLMNVAINE 497 +IVQ KQ L Q+ + + + K ++E + S I + E + + +N ++ Sbjct: 512 NEIVQEKQSL--QNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSS 569 Query: 498 LNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESK 557 L + Q + + K E+ IL E ++ + ++ F + QI++ + E+ + Sbjct: 570 LRQRSQISAEARVKDIEKENKILHESI---KETSSKLSKIEFEKRQIKKELEHYKEKGER 626 Query: 558 LNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLE--KEKNAVLDRMA 615 E L +E KE EL + ++TN KI E +E +++N+ L+R Sbjct: 627 AEELENELHHLE-------------KENELLQK-KITNLKITCEKIEALEQENSELEREN 672 Query: 616 ESQEAELERLR--TQLLFSHEEELSKLKEDLEIEHRINIEKLK------DNLGIHYKQQI 667 + L+ + T L S E+E S+L E+ +E R N+E LK L + K+ + Sbjct: 673 RKLKKTLDSFKNLTFQLESLEKENSQLDEE-NLELRRNVESLKCASMKMAQLQLENKE-L 730 Query: 668 DGLQNEMSQKIETMQ--FEK-DNLITKQNQLILEISKL--------KDLQQSLVNSKSEE 716 + + ++ + +E ++ F+K + L L +E +L K +QQ + S+ ++ Sbjct: 731 ESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQ--LESELQD 788 Query: 717 MTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAE 776 + ++ LQK +E L+ K LE+E + L+ +T LEK K+ E + + Q E + Sbjct: 789 LEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIK 848 Query: 777 NSILKDEKKTLEDMLKIHTPVSQE-----ERLIFLDSIKSKSKDSVWEKEIEI--LIEEN 829 ++ L++ + ++ K + +S+E E + L ++ ++K+ V I+I L+ Sbjct: 849 DTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLR 908 Query: 830 EDL---KQQCIQLNEEIEK----------QRNTFSFAEKNFEVNYQELQEEYACLLK--- 873 EDL K + Q+N ++EK + E++ + Y+ L+ + LK Sbjct: 909 EDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSL 968 Query: 874 -VKDD--------LEDSKN-KQELEYKSKLKALNEELHLQRIN-PTTVKMKSSVFDEDKT 922 +K++ LE+S N Q+L + K N E QR + V+ + ED Sbjct: 969 EIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNK 1028 Query: 923 FVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKS 982 + E+ E ++ ++ ++L +R L L QLKQ + + L ++ + Sbjct: 1029 WERESQE----TTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILA 1084 Query: 983 LKQEKEQVSLRCRELEIIINHNRAENVQSCDTQV--SSLLDGVVTMTSRGAEGSVSKVNK 1040 L +++ VSL+ N Q+ QV S+L ++ ++ A+ + + Sbjct: 1085 L--QRQTVSLQ--------EQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQ--S 1132 Query: 1041 SFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELN 1100 S E++ +++++ +++ + LI DH K L Q SE + L + Sbjct: 1133 SLENENESVIKEREDLKSL-------YDSLIKDH----EKLELLHERQASEYESLISKHG 1181 Query: 1101 VLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKE 1160 LKS +L ++ H D Y + + Q+ ++++ Sbjct: 1182 TLKSAHKNLEVE--------------HRDLEDRYNQ--------------LLKQKGQLED 1213 Query: 1161 LQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSV---LGEYYTPA 1217 L+K+ ++E + M LL K + V+ E + LC L Y+ Sbjct: 1214 LEKMLKVEQEKM-------------LLENKNHETVAAE----YKKLCGENDRLNHTYSQL 1256 Query: 1218 LK-CEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTR 1276 LK EV D +N ++ + +L+ R E + +K+ E+Y +L + T+ Sbjct: 1257 LKETEVLQTDHKNLKSLLNNS---KLEQTRLEAE---------FSKLKEQYQQLDITSTK 1304 Query: 1277 LSKIWGQQTDGMKLEFGEEN---LPKEETEFLSIHSQM-TNLEDIDVNH---KSKLSSLQ 1329 L+ + +K EEN L + +T L + + N+E D+ H + + L Sbjct: 1305 LNN-QCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLN 1363 Query: 1330 DL--EKTKLEEQVQE 1342 +L +K KLEE++ + Sbjct: 1364 ELRRQKEKLEEKIMD 1378 Score = 149 bits (376), Expect = 5e-35 Identities = 292/1336 (21%), Positives = 554/1336 (41%), Gaps = 234/1336 (17%) Query: 1591 RQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQ---------EEIKRL--NRQLAQ 1639 ++E + + Q T+ AH++++ +E+ LQ E+I+ L N L Sbjct: 138 KEEFIERIQGLDFDTKAAVAAHIQEVTHNQENVFDLQWMEVTDMSQEDIEPLLKNMALHL 197 Query: 1640 RSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQT 1699 + ID + SE L EE + L L A +SS Q+ G+ E + Sbjct: 198 KRLIDERDEHSETIIELSEERDGLHFLPHA----------SSSAQSPCGSPGMKRTESRQ 247 Query: 1700 FKEKEL-DRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILD 1758 EL D K + + R L++ +LL E+ + ++ + + + +L Sbjct: 248 HLSVELADAKAK------IRRLRQELEEKTEQLLDCKQELEQMEIELKR-LQQENMNLL- 299 Query: 1759 RSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEG 1818 S + ++ ++R E +A + E+ RV D+ S +DI + EE Sbjct: 300 ----SDARSARMYRDELDA-----LREKAVRV-DKLESEVSRYKERLHDIEFYKARVEEL 349 Query: 1819 TELSQRLVRSG------FAGT--------EIDPENEELMLNISS-RLQAAVE-KLLEAIS 1862 E +Q L+ + GT E++ EN +L + ++ ++ K +E + Sbjct: 350 KEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELM 409 Query: 1863 ETSSQLEHAKVTQTELMRESFRQKQEATESLKCQE-----------ELRE-------RLH 1904 E + LE A Q + M ES E + + E E+ E +L Sbjct: 410 EENMTLEMA---QKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLE 466 Query: 1905 EESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEA 1964 E+++ + EL ++G A + E++ Q + ++ LE E++ LQ + Sbjct: 467 MENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQN 526 Query: 1965 EQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKE----KLEVQCQAEKVRDDLQ 2020 + + +E+ L + E ++ + + L QE E L + + Q AE D++ Sbjct: 527 LSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIE 586 Query: 2021 KQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHER 2080 K+ K L ++E S+ ++E EK RQ + LE EK E+A + E+E Sbjct: 587 KENKILHESIKETSSKLSKIEFEK-------RQIKKELEHYKEK-----GERAEELENEL 634 Query: 2081 DVFQQE---IQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQR 2137 ++E +QK LK+ E + E+E+ LK+ D L E L++ Sbjct: 635 HHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEK 694 Query: 2138 DIQERNEEIEKLEFRVRELE-----QALLVEDRKHFGAVEAKPELSLEVQLQAERDAIDR 2192 + + +EE +L V L+ A L + K + + + + LE+ L+A +R Sbjct: 695 ENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLEL-LKASFKKTER 753 Query: 2193 KEKEITNLEEQLEQFREELENKNEEVQQLHMQLE--------IQK-----KESTTRLQEL 2239 E L+ + ++ ++ LEN N+++QQL +L+ +QK K S+ RL++L Sbjct: 754 LEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQL 813 Query: 2240 EQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQI----IQEKEVEIDQLNEQVTK 2295 E+ENK + + +L E D + ++ + A+I ++E V+I L ++ Sbjct: 814 EKENKSLEQETSQL-----EKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKT 868 Query: 2296 LQQQLKITTDN----KVIEEKN-ELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEK 2350 L +++ I ++ K +E++N EL++ I+ L++ +E + + + + +Q+N +EK Sbjct: 869 LSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLV-SEKLKTQQMNNDLEK 927 Query: 2351 LQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKL--ALEQQVETANEEMTFMKNVL 2408 L EL IG H D K ++ KL L++ +E E++ ++ L Sbjct: 928 LTHELEKIGLNKERLLHDEQSTDDRYK-----LLESKLESTLKKSLEIKEEKIAALEARL 982 Query: 2409 KETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKS 2468 +E+ QL QEL ++K+ E++++ Q E +V + + Sbjct: 983 EESTNYNQQLRQELKTVKKNYEALKQRQD------------------EERMVQSSPPISG 1024 Query: 2469 LENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEML 2528 +N+ +S E + ++ ++ RL+++E + E Q+K ++ Q L Sbjct: 1025 EDNKWERESQETTRE--LLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNN----NL 1078 Query: 2529 QKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDE 2588 Q +I+ LQ+ QT+S + + T +Q N Sbjct: 1079 QAQILALQR-----------------------------QTVSLQEQNTTLQTQN------ 1103 Query: 2589 LGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKK 2648 + L + S L SQ TSL+ + Q+ I + + LE E NE Sbjct: 1104 -----AKLQVENSTLNSQ----STSLMNQNAQLLIQQSS-LENE------------NESV 1141 Query: 2649 QREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQ 2708 +E+E +S D L +E+ +E +A ES+ +K K +++ Sbjct: 1142 IKEREDLKSLYD--------SLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVE 1193 Query: 2709 EELLVKETNMTSLQK-DLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLS 2767 L N QK L + L +EK+ + K ET E KK C +L+ Sbjct: 1194 HRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGEND---RLN 1250 Query: 2768 KSIASQTDGTLKISSSNQTPQILVKNAGI-QINLQSECSS-EEVTEIISQFTEKIEKMQE 2825 + + T + + ++ + L+ N+ + Q L++E S +E + + + K+ E Sbjct: 1251 HTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCE 1310 Query: 2826 L--HAAEILDMESRHI 2839 L L+ E+RH+ Sbjct: 1311 LLSQLKGNLEEENRHL 1326 Score = 145 bits (367), Expect = 6e-34 Identities = 269/1212 (22%), Positives = 519/1212 (42%), Gaps = 190/1212 (15%) Query: 1511 KEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDK----TFIVRQSIH 1566 K+E + + EL +E + SD +D + + E+ DK ++ +H Sbjct: 278 KQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLH 337 Query: 1567 D----EISVSSMDASRQLMLN-----EEQLEDMRQELVRQYQEHQQATELLRQAHMRQME 1617 D + V + Q++L E+QLE R + ++ ++ +L + H +ME Sbjct: 338 DIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEME 397 Query: 1618 RQ--REDQEQLQEEIKRLNRQLAQRSSIDNE-NLVSERERVL-LEELEALKQLSLA---- 1669 R R+ E+L EE + ++AQ+ S+D +L E E++ EL Q SL Sbjct: 398 RDMDRKKIEELMEE--NMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVN 455 Query: 1670 ---GREKLCCELRNSS---------TQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEIL 1717 L E+ N S T + N ++ + + + L +K E + EI+ Sbjct: 456 ELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIV 515 Query: 1718 SNERYALQKANNR---LLKILLEVVKTTAAVEETIGRHVLGILDRSSK--SQSSASLIWR 1772 E+ +LQ N L+K ++ KT + E R + IL++ ++ +Q+ +SL R Sbjct: 516 Q-EKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIK-ILEQENEHLNQTVSSLRQR 573 Query: 1773 SEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAG 1832 S+ A + E+ ++ ESI E S +L + F Sbjct: 574 SQISAEARVKDIEKENKILHESIK-----------------------ETSSKLSKIEFEK 610 Query: 1833 TEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATES 1892 +I E E ++ E E ++L H + + EL+++ + E Sbjct: 611 RQIKKELEHY------------KEKGERAEELENELHHLE-KENELLQKKITNLKITCEK 657 Query: 1893 LKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQEL 1952 ++ E+ L E+R ++ ++ E + Q+ E+ + R + L Sbjct: 658 IEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENS----QLDEENLELRRNVESL 713 Query: 1953 LCASNRLQELEAEQQQIQEERELLSRQKEAMKA------------EAGPVEQQLLQETEK 2000 CAS ++ +L+ E ++++ E+E L + E +KA + +E Q LQ+T + Sbjct: 714 KCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLE 773 Query: 2001 LMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQ--VSRFIELEQEKNTELMDLRQQNQAL 2058 +K++ Q E DL+ + + L+ ++EE S+ +E +++N L Q + Sbjct: 774 NSNKKIQ---QLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKD 830 Query: 2059 EKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHL 2118 +KQLEK K L +QA ++ + +I LE++ K + + I + +++L Sbjct: 831 KKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKEN 890 Query: 2119 KEKTDKCSELLLSKEQLQRDI-------QERNEEIEKLEFRVRELEQALLVEDRKHFGAV 2171 KE + + + + L+ D+ Q+ N ++EKL ELE Sbjct: 891 KELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKL---THELE-------------- 933 Query: 2172 EAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKE 2231 K L+ E L E+ DR + + LE L ++ LE K E++ L +LE E Sbjct: 934 --KIGLNKERLLHDEQSTDDRYKLLESKLESTL---KKSLEIKEEKIAALEARLE----E 984 Query: 2232 STTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNE 2291 ST Q+L QE K K + E L ++ + Q + G+ + E E + Sbjct: 985 STNYNQQLRQELKTVKKNYE--ALKQRQDEERMVQSSPPISGE----DNKWERESQETTR 1038 Query: 2292 QVTKLQQQL-KITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEK 2350 ++ K++ +L ++ +N ++ + + L+TQ++ L E N + +I L Sbjct: 1039 ELLKVKDRLIEVERNNATLQAEKQA---LKTQLKQL----ETQNNNLQAQILALQRQTVS 1091 Query: 2351 LQQE---LANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNV 2407 LQ++ L K + +L+ ++ SL +Q ++ ++ +LE + E+ +E +K++ Sbjct: 1092 LQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSL 1151 Query: 2408 ---LKETNFKMNQLTQELFSLKRERES-VEKIQSIPENSVNVAIDHLSKDKPELEVVLTE 2463 L + + K+ L + S E ES + K ++ N+ ++H + +++ + Sbjct: 1152 YDSLIKDHEKLELLHERQAS---EYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQK 1208 Query: 2464 DALKSLENQTYFKSFEENGKGSIINLETRLLQLES----TVSAKDLELTQCYKQIKDMQE 2519 L+ LE ++ +E + LE+ TV+A+ +L ++ Sbjct: 1209 GQLEDLE--------------KMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYS 1254 Query: 2520 QGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQ 2579 Q ETE+LQ NL+ ++ + + Q +LEA E++K + Q + + N Q Sbjct: 1255 QLLKETEVLQTDHKNLKSLLNN----SKLEQTRLEA--EFSKLKEQYQQLDITSTKLNNQ 1308 Query: 2580 --NLNQLR---EDE---LGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEK 2631 L+QL+ E+E L I L L+ L Q +E +E+ Q I + N L + Sbjct: 1309 CELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQY-IDKLNELRR 1367 Query: 2632 EKKLLELQKLLE 2643 +K+ LE +K+++ Sbjct: 1368 QKEKLE-EKIMD 1378 Score = 145 bits (366), Expect = 8e-34 Identities = 292/1387 (21%), Positives = 576/1387 (41%), Gaps = 214/1387 (15%) Query: 1427 NIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQ----QTELSRISGGKENTASSKQAHAVCQ 1482 N++ + + + EQ EEV K+++ + Q + + RI G +T ++ AH Sbjct: 104 NVLIIGKNPFSEQGTEEVKKLLLLLLGCAVQCQKKEEFIERIQGLDFDTKAAVAAH---- 159 Query: 1483 QEQHYFNEMKLSQDQI-GFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPH----- 1536 E+ +Q+ + Q E D+ +E+ +PL K + H K L+ D H Sbjct: 160 -----IQEVTHNQENVFDLQWMEVTDMS-QEDIEPLLKNMALHLKR-LIDERDEHSETII 212 Query: 1537 DIPESKDCVLTISEEMFSKDKTF----IVRQSIHDEISVSSMDA--------------SR 1578 ++ E +D + + S + R +SV DA + Sbjct: 213 ELSEERDGLHFLPHASSSAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTE 272 Query: 1579 QLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLA 1638 QL+ +++LE M EL R QE+ R A M R++ + L+E+ R+++ + Sbjct: 273 QLLDCKQELEQMEIELKRLQQENMNLLSDARSARM-----YRDELDALREKAVRVDKLES 327 Query: 1639 QRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQ 1698 + S E + +EEL+ Q+ L + L +L + ++ +E + E + Sbjct: 328 EVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQL 387 Query: 1699 TFK------EKELDRKP-EDVPPEILSNERYALQKANNRL-LKILLEVVKTTAAVEETIG 1750 K E+++DRK E++ E ++ E Q + L L LE + T+ + E Sbjct: 388 KAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQ 447 Query: 1751 RHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINM 1810 + L +S+ L+ S+ V E T V D + + Sbjct: 448 KS----LGHEVNELTSSRLLKLEMENQSLTKTVEELRTTV-----------DSVEGNASK 492 Query: 1811 WSKVTEEGTELSQRLVRSGFAGTEIDPENEELM--LNISSRL---QAAVEKLLEAISETS 1865 K+ +E LS+++ EI E + L N+S L +A +EK +E + E S Sbjct: 493 ILKMEKENQRLSKKV---EILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENS 549 Query: 1866 --------SQLEHAKVTQTELMRESFRQKQEATESLKCQEE-LRERLHEESRAREQLAVE 1916 + EH T + L + S + + ++ + + L E + E S ++ E Sbjct: 550 ERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFE 609 Query: 1917 LSKAEGVIDGYADEKTLFE------RQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQ 1970 + + ++ Y ++ E ++++ +++ + L +++ LE E +++ Sbjct: 610 KRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELE 669 Query: 1971 EERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVR------DDLQKQVK 2024 E L + ++ K +E L +E +L +E LE++ E ++ LQ + K Sbjct: 670 RENRKLKKTLDSFKNLTFQLE-SLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENK 728 Query: 2025 ALEIDVEEQVSRFIELEQE--KNTELMDLRQQ-----NQALEKQLEKMRKFLDEQAIDRE 2077 LE + +EQ+ + +EL + K TE +++ Q NQ L+K LE K + +Q Sbjct: 729 ELESE-KEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKI-QQLESEL 786 Query: 2078 HERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQR 2137 + ++ Q +QK ++LK+ ++ +EQL K + S+L K+QL++ Sbjct: 787 QDLEMENQTLQKNLEELKI----------SSKRLEQLEKENKSLEQETSQLEKDKKQLEK 836 Query: 2138 DIQERNEEIEKLEFRVRELEQALLVEDRKHFGAVEAKPE-LSLEVQLQAERDAIDRKEKE 2196 + + ++ E++ L E+ G +E + + LS E+ + E + KE E Sbjct: 837 ENKRLRQQ--------AEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKE-SCVRLKELE 887 Query: 2197 ITNLE---------EQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFK 2247 N E + L RE+L ++ + QQ++ LE Sbjct: 888 KENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLE------------------KLT 929 Query: 2248 DDMEKLGLAIKE--SDAMSTQDQHVL--------FGKFAQIIQEKEVEIDQLNEQVTKLQ 2297 ++EK+GL + D ST D++ L K +I +EK ++ E+ T Sbjct: 930 HELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYN 989 Query: 2298 QQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNR--EEEIEQLNEVIEKLQQEL 2355 QQL+ + K +++ E ++ + + + S + E E ++ + K++ L Sbjct: 990 QQLR--QELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRL 1047 Query: 2356 ANIGQKTS---MNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETN 2412 + + + +L + L+ Q + + A+ LAL++Q + E+ T ++ + Sbjct: 1048 IEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQ 1107 Query: 2413 FKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQ 2472 + + L + SL + + QS EN I K++ +L+ L + +K E Sbjct: 1108 VENSTLNSQSTSLMNQNAQLLIQQSSLENENESVI----KEREDLK-SLYDSLIKDHEKL 1162 Query: 2473 TYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKI 2532 + + S+I+ L + + +L Y Q+ ++++GQ E L+K + Sbjct: 1163 ELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQL--LKQKGQLED--LEKML 1218 Query: 2533 VNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDE-LGS 2591 K+ +EK+ L ++ EY K C +N +R N L+E E L + Sbjct: 1219 ----KVEQEKM--LLENKNHETVAAEYKKLCGEN-------DRLNHTYSQLLKETEVLQT 1265 Query: 2592 DISAL--TLRISELESQVVEMHTSLILEK-EQVEIAEKNVLEKEKKLLELQKLLEGNEKK 2648 D L L S+LE +E S + E+ +Q++I + + + L +L+ LE + Sbjct: 1266 DHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRH 1325 Query: 2649 QREKEKKRSPQDVEVLKTTTE---LFHSNEESGFFNELEALRAESVATKAELASYKEKAE 2705 ++ + Q+ +L+ E LFH E+ + ++L LR + E Sbjct: 1326 LLDQIQTLMLQNRTLLEQNMESKDLFHV-EQRQYIDKLNELRRQK--------------E 1370 Query: 2706 KLQEELL 2712 KL+E+++ Sbjct: 1371 KLEEKIM 1377 Score = 131 bits (329), Expect = 1e-29 Identities = 203/993 (20%), Positives = 450/993 (45%), Gaps = 146/993 (14%) Query: 2 EDEERQKKLEAGKAKLAQFRQ--RKAQSDGQSPSKKQKKKRKTSSSKHDVSAHHDLNIDQ 59 E++ KK+E + ++ Q +Q + Q+ + K++ + KT + + S ++Q Sbjct: 499 ENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQ 558 Query: 60 SQCNEMYINSSQRVESTVIPESTIMRTLHSGEITSHEQGFSVELESEI-STTADDCSSEV 118 + SS R S + E+ + +E E++I + + SS++ Sbjct: 559 ENEHLNQTVSSLRQRSQISAEARVK---------------DIEKENKILHESIKETSSKL 603 Query: 119 NGCSFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHEIEELNREL 178 + F R K +E E Y E+G + E +E+EL + E E L +++ Sbjct: 604 SKIEFEKRQIK-----KELEH-----YKEKGER-----AEELENELHHLEKENELLQKKI 648 Query: 179 EEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKL 238 +++T ++ EA + Q + L++ R+ +T+ F LT Q + L Sbjct: 649 TNLKIT--------CEKIEA--------LEQENSELERENRKLKKTLDSFKNLTFQLESL 692 Query: 239 QIQFQQLQASET-LRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDF--T 295 + + QL LR + S A + A+ Q L +++ E++ L + + K F T Sbjct: 693 EKENSQLDEENLELRRNVESLKCASMKMAQLQ-LENKELESEKEQLKKGLELLKASFKKT 751 Query: 296 MQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELK-DKLTT 354 ++ + + + K +ENSNK+ IQ+ E+ +++L E E +TL+ ++L Sbjct: 752 ERLEVSYQGLDIENQRLQKTLENSNKK-IQQLESELQDL-----EMENQTLQKNLEELKI 805 Query: 355 ADKLLGELQEQ---IVQKNQEIKNMKLELTNSKQKERQSSE-------EIKQLMGTVEEL 404 + K L +L+++ + Q+ +++ K +L ++ RQ +E E +G +E+ Sbjct: 806 SSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKE 865 Query: 405 QKRNHKD-SQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEM 463 K K+ ++ V+ E E + K RA +D + +V ++++L+ E++ Sbjct: 866 NKTLSKEIGIYKESCVRLKELEKENKELVKRATIDI---KTLVTLREDLVS------EKL 916 Query: 464 KTRH-KGEMENALRSYSNITVNEDQIKLMNVAINE----LNIKLQDTNSQKEKLKEELGL 518 KT+ ++E I +N++++ + ++ L KL+ T + ++KEE Sbjct: 917 KTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIA 976 Query: 519 ILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSA 578 LE + +EE + +Q+++ +T+ + L + V+ + +S Sbjct: 977 ALEAR----------LEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQS--SPPISG 1024 Query: 579 SESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELS 638 +++ E E E K+K ++E E+N + +AE + L+TQL E + + Sbjct: 1025 EDNKWERE-SQETTRELLKVKDRLIEVERNNA------TLQAEKQALKTQLK-QLETQNN 1076 Query: 639 KLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILE 698 L+ + R + + N + + Q LQ E S T+ + +L+ + QL+++ Sbjct: 1077 NLQAQILALQRQTVSLQEQNTTL--QTQNAKLQVENS----TLNSQSTSLMNQNAQLLIQ 1130 Query: 699 ISKLKDLQQSLVNSKSEEMTLQINELQ--KEIEILRQEEKEK--------GTLEQEVQEL 748 S L++ +S++ + + +L + ++ +++E+L + + + GTL+ + L Sbjct: 1131 QSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNL 1190 Query: 749 QLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDS 808 +++ + ++++ N L ++ QLE +LK E++ + K H V+ E + + ++ Sbjct: 1191 EVE----HRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGEN 1246 Query: 809 IKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEY 868 + S KE E+L ++++LK + N ++E+ R E + +L+E+Y Sbjct: 1247 DRLNHTYSQLLKETEVLQTDHKNLKS--LLNNSKLEQTR---------LEAEFSKLKEQY 1295 Query: 869 ACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETL 928 L D+ +K + E S+LK +L+ N + ++ +++T + + + Sbjct: 1296 QQL-----DITSTKLNNQCELLSQLKG-----NLEEENRHLLDQIQTLMLQNRTLLEQNM 1345 Query: 929 EMGEVVEKDTTELMEKLEVTKREKLELSQRLSD 961 E ++ + + ++KL +R+K +L +++ D Sbjct: 1346 ESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMD 1378 Score = 119 bits (299), Expect = 5e-26 Identities = 314/1511 (20%), Positives = 612/1511 (40%), Gaps = 249/1511 (16%) Query: 1990 VEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQE------ 2043 V+ L + + KLE Q +KV +D ++ L I V + + E Q+ Sbjct: 43 VDGVFLNQVMLQINPKLESQRVNKKVNNDASLRMHNLSILVRQIKFYYQETLQQLIMMSL 102 Query: 2044 KNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLK--VVPRFQ 2101 N ++ ++ ++++K+ L A+ + +++ F + IQ L+ K V Q Sbjct: 103 PNVLIIGKNPFSEQGTEEVKKLLLLLLGCAVQCQ-KKEEFIERIQGLDFDTKAAVAAHIQ 161 Query: 2102 PISEHQTREVEQLANHLKEKTDKCSELLLSKE--QLQRDIQERNEEIEKLEFRVRELEQA 2159 ++ +Q + + + + + E LL L+R I ER+E E + EL + Sbjct: 162 EVTHNQENVFDLQWMEVTDMSQEDIEPLLKNMALHLKRLIDERDEHSET----IIELSEE 217 Query: 2160 LLVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEK------EITNLEEQLEQFREELEN 2213 D HF P S Q + R E E+ + + ++ + R+ELE Sbjct: 218 ---RDGLHF-----LPHASSSAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQELEE 269 Query: 2214 KNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFG 2273 K E++ +LE + E L+ L+QEN D + E DA+ Sbjct: 270 KTEQLLDCKQELEQMEIE----LKRLQQENMNLLSDARSARMYRDELDAL---------- 315 Query: 2274 KFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECV 2333 +EK V +D+L +V++ + E + D+E Sbjct: 316 ------REKAVRVDKLESEVSRYK----------------ERLHDIEFY----------- 342 Query: 2334 KRNREEEIEQLNEVIEKLQQELANIGQKT---SMNAHSLSEEADSLKHQLDVVIAEKLAL 2390 + R EE+++ N+V+ + + L + + T S H L +E LK +L + E+ Sbjct: 343 -KARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMD 401 Query: 2391 EQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHL 2450 +++E EE ++ K++ + L EL + R E + P+ S+ ++ L Sbjct: 402 RKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSE----LSEAPQKSLGHEVNEL 457 Query: 2451 SKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQC 2510 + + + + K++E E I+ +E +L V + E+ Q Sbjct: 458 TSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQE 517 Query: 2511 YKQIKDMQEQGQF---ETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQ 2567 + +++ Q + E L+K I L++ E ++ LE E+ NQ Sbjct: 518 KQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKI-------LEQENEHL-----NQ 565 Query: 2568 TISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKN 2627 T+SS +R+ I ++++ E + I L I E S++ ++ EK Q++ ++ Sbjct: 566 TVSSLRQRSQISAEARVKDIEKENKI--LHESIKETSSKLSKIE----FEKRQIKKELEH 619 Query: 2628 VLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALR 2687 EK ++ EL+ NE EKE + + + LK T E + E+ E L Sbjct: 620 YKEKGERAEELE-----NELHHLEKENELLQKKITNLKITCEKIEALEQ-----ENSELE 669 Query: 2688 AESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAK------EKLSI 2741 E+ K L S+K +L E L KE + L ++ ++R ++ K +L + Sbjct: 670 RENRKLKKTLDSFKNLTFQL--ESLEKENSQ--LDEENLELRRNVESLKCASMKMAQLQL 725 Query: 2742 LEKEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQIN-L 2800 KE E+E ++ KK K ++ + G + NQ Q ++N+ +I L Sbjct: 726 ENKELESEKEQLKKGLELLKASFKKTERLEVSYQG---LDIENQRLQKTLENSNKKIQQL 782 Query: 2801 QSECSSEEVTEIISQFTEKIEKMQELHAA----EILDMESRHIS-ETETLKREHYVAVQL 2855 +SE E+ Q + ++EL + E L+ E++ + ET L+++ + Sbjct: 783 ESELQDLEMENQTLQ-----KNLEELKISSKRLEQLEKENKSLEQETSQLEKDK----KQ 833 Query: 2856 LKEECGTLK--AVIQCLRSKEGS-SIPELAHSDAYQTREICSSDSGSDWGQGIYLTHSQG 2912 L++E L+ A I+ +E + I L + ++EI GIY Sbjct: 834 LEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEI-----------GIY------ 876 Query: 2913 FDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPW 2972 +ES K+ K L++ + +++L E S E QQ++ Sbjct: 877 ---------KESCVRLKELEKENKELVKRATIDIKTLVTLREDLVS--EKLKTQQMN--- 922 Query: 2973 LEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSV 3032 N + L + K+ L +E ++D + + + +L L++ LE + Sbjct: 923 --------NDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKS-LEIKEE 973 Query: 3033 LLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQ 3092 +AA L ++ L Q ++ Y+A Q+ D ++ + + Sbjct: 974 KIAALEARLE-----ESTNYNQQLRQELKTVKKNYEALK---QRQDEERMVQSSPPISGE 1025 Query: 3093 MNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMV 3152 N K E+ES++ ++ELL+ +KDR E++ ++ + Sbjct: 1026 DN------KWERESQETTRELLK-------------------VKDRLIEVERNNATLQAE 1060 Query: 3153 VAELKSELAQTKLE---LETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKS 3209 LK++L Q + + L+ + A + L+ ++ + ++ + N TL S+ Sbjct: 1061 KQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSL 1120 Query: 3210 RELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQ--------- 3260 L +++ L E +E EDLK +S + + +L LL E+Q Sbjct: 1121 MNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKH 1180 Query: 3261 -LLNESQQKIE-SQRMLYDA--QLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHA 3316 L + + +E R L D QL +++G+ +L+ +L KV +M + A Sbjct: 1181 GTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKML---KVEQEKMLLENKNHETVAA 1237 Query: 3317 QLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDR 3376 + + G S+ LLKE + L+ H + LLN + KL+ + + K + Sbjct: 1238 EYKKLCGENDRLNHTYSQ-LLKETE-VLQTDHKNLKSLLNNS---KLEQTRLEAEFSKLK 1292 Query: 3377 QVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQ 3436 + +++ T + N + + + +L+ +E+ R L + Q+ L L+ + L + Q + Sbjct: 1293 EQYQQLDITSTKLNNQCE-LLSQLKGNLEEENRHLLD---QIQTLMLQNRTL--LEQNME 1346 Query: 3437 KQELEREEKRE 3447 ++L E+R+ Sbjct: 1347 SKDLFHVEQRQ 1357 Score = 112 bits (279), Expect = 9e-24 Identities = 238/1133 (21%), Positives = 449/1133 (39%), Gaps = 180/1133 (15%) Query: 2618 KEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEES 2677 K ++ + + EK ++LL+ ++ LE Q E E KR Q+ L L + Sbjct: 257 KAKIRRLRQELEEKTEQLLDCKQELE-----QMEIELKRLQQENMNL-----LSDARSAR 306 Query: 2678 GFFNELEALRAESVAT---KAELASYKEK----------AEKLQEELLVKETNMTSLQKD 2724 + +EL+ALR ++V ++E++ YKE+ E+L+E+ V T L+ Sbjct: 307 MYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQ 366 Query: 2725 LSQVR---DHLAEA-KEKLSILEKEDETEVQESKKACMFEPLP---IKLSKSIASQTDGT 2777 L R D L E KE L + K + E++ E L + L + D + Sbjct: 367 LEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDES 426 Query: 2778 L-------KISSSNQTPQILVKNAGIQIN-------LQSECSSEEVTEIISQFTEKIEKM 2823 L +IS +++ + K+ G ++N L+ E ++ +T+ + + ++ + Sbjct: 427 LHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSV 486 Query: 2824 QELHAAEILDMESRH--------------ISETETLKREHYVAVQLLKEECGTLKAVIQC 2869 E +A++IL ME + + E ++L+ ++ L+KE+ L+ I+ Sbjct: 487 -EGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEK-AQLEKTIET 544 Query: 2870 LRSKEGSSIPELAHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESESATD 2929 LR I L + + + + S Q I++E R ++ E Sbjct: 545 LRENSERQIKILEQENEHLNQTVSSL--------------RQRSQISAEARVKDIEKENK 590 Query: 2930 SFPKKIK---GLLRAVHNEGMQVLSLTESPYSDGE-DHSIQQVSEPWLEERKAYINTISS 2985 + IK L + E Q+ E GE ++ +E + I++ Sbjct: 591 ILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITN 650 Query: 2986 LKDLITKMQL--QREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTA 3043 LK K++ Q +E+ ++ + D L L+ LE+ + L EL Sbjct: 651 LKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLES--LEKENSQLDEENLELRR 708 Query: 3044 LGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADR--RSLLSEIQALHAQMNGRKITLK 3101 +++ + ++Q + E ++ E L+K ++ + + L G I + Sbjct: 709 --NVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQ 766 Query: 3102 REQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQ------EQLSSEKMVVAE 3155 R Q++ + S + IQQ +S++ ++++E +++ EL+ EQL E + + Sbjct: 767 RLQKTLENSNK----KIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQ 822 Query: 3156 LKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLL--------NDTLASE-- 3205 S+L + K +LE ++K L++ + E+KD T E + + N TL+ E Sbjct: 823 ETSQLEKDKKQLE----KENKRLRQ----QAEIKDTTLEENNVKIGNLEKENKTLSKEIG 874 Query: 3206 -QKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQ------- 3257 K+S LEKE +L + D + L L+ L S+K + Q+N LE+ Sbjct: 875 IYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEK 934 Query: 3258 ---QKQLLNESQQKIESQRMLYDAQLSEEQGRNLE--------LQVLLESE---KVRIRE 3303 K+ L +Q + + L +++L ++LE L+ LE ++R+ Sbjct: 935 IGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQ 994 Query: 3304 MSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKL 3363 T+ + E Q Q + QS PP+ ED K E ELL ++ + Sbjct: 995 ELKTVKKNYEALKQRQDEERMVQSSPPISGED-----NKWERESQETTRELLKVKDRL-I 1048 Query: 3364 DSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDL 3423 + + ++ ++Q + L+ + N Q ++ LQ + LQ Q + Q KL + Sbjct: 1049 EVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQV 1108 Query: 3424 EGQRL---------QGIMQEFQKQELERE-----EKRESRRILYQNLNEPTTWSLTSDRT 3469 E L Q Q+ LE E ++RE + LY SL D Sbjct: 1109 ENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYD--------SLIKDHE 1160 Query: 3470 RNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMIRQKLQCVASKLQVLPQKASERL 3529 + +L E + S Y LI +G + LE+ + L+ ++L + + Sbjct: 1161 KLELLH-----ERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLE 1215 Query: 3530 QFETADDEDFIWVQENIDEIILQLQKLTGQQG-----------EEPSLVSPSTSCGSLTE 3578 + + E + +N + + + +KL G+ E L + + SL Sbjct: 1216 KMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLN 1275 Query: 3579 RLLRQNAELTGHISQLTEEKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRFSLN 3631 + L S+L E+ L KL Q Q + +R L+ Sbjct: 1276 NSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLD 1328 Score = 96.7 bits (239), Expect = 4e-19 Identities = 270/1363 (19%), Positives = 566/1363 (41%), Gaps = 205/1363 (15%) Query: 651 NIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLV 710 +IE L N+ +H K+ ID ++E S+ I + E+D L + S Sbjct: 185 DIEPLLKNMALHLKRLIDE-RDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGMKRT 243 Query: 711 NSKSEEMTLQINELQKEIEILRQEEKEKGT----LEQEVQELQLKTELLEKQMKEKENDL 766 S+ + +++++ + + +I LRQE +EK +QE+++++++ + L+++ +D Sbjct: 244 ESR-QHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDA 302 Query: 767 QEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQ-EERLIFLDSIKSKSKDSVWEKEIEIL 825 + A++ + EK D K+ + VS+ +ERL ++ K++ +E L Sbjct: 303 RS--ARMYRDELDALREKAVRVD--KLESEVSRYKERLHDIEFYKAR---------VEEL 349 Query: 826 IEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQ 885 E+N+ L + L +++E R + ++K E+ + LQ +K L D + ++ Sbjct: 350 KEDNQVLLETKTMLEDQLEGTR---ARSDKLHELEKENLQ--------LKAKLHDMEMER 398 Query: 886 ELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKL 945 +++ K + + E + L+ ++ +S + ++ T E+ E +K + +L Sbjct: 399 DMDRKKIEELMEENMTLEMAQKQSMD-ESLHLGWELEQISRTSELSEAPQKSLGHEVNEL 457 Query: 946 EVTKREKLEL-SQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINH- 1003 ++ KLE+ +Q L+ E+L+ + K LK EKE L +++EI+ N Sbjct: 458 TSSRLLKLEMENQSLTKTVEELRTTVDSVE--GNASKILKMEKENQRLS-KKVEILENEI 514 Query: 1004 -NRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVG 1062 +++Q+C L+ + E ++ + ++ + KI+ ++ N TV Sbjct: 515 VQEKQSLQNCQNLSKDLMKEKAQL-----EKTIETLRENSERQIKILEQENEHL-NQTVS 568 Query: 1063 EESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSL 1122 ++ Q ++ E+ ++ + EN L + + S+ + +++ E ++I L Sbjct: 569 SLRQRSQ--------ISAEARVKDIE-KENKILHESIKETSSKLS--KIEFEKRQIKKEL 617 Query: 1123 VYSTHVDQVREYMENE-----KDKALCSLKEELIFAQEEKIKEL-QKIHQLELQTMKTQE 1176 + + E +ENE K+ L K + EKI+ L Q+ +LE + K ++ Sbjct: 618 EHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKK 677 Query: 1177 TGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISE 1236 T D K L + L+K S+ L+ +V ++ E+KE + Sbjct: 678 TLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQL 737 Query: 1237 NEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEEN 1296 + EL ++ + E + L+ + K L+ KI +++ LE + Sbjct: 738 KKGLELLKASFKKTERLEVSYQGLDIENQRLQK--TLENSNKKIQQLESELQDLEMENQT 795 Query: 1297 LPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKE 1356 L K NLE++ ++ K +L L+ E LE++ +LE L+++ K Sbjct: 796 LQK-------------NLEELKISSK-RLEQLEK-ENKSLEQETSQLEKDKKQLEKENKR 840 Query: 1357 TEQNYEAEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEF 1416 Q E + ++T+ + + G+ K+N Sbjct: 841 LRQQAE------------IKDTTL---------------EENNVKIGNLEKEN----KTL 869 Query: 1417 SGEFGVKEETNI-VKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSK 1475 S E G+ +E+ + +K LEK+ +E ++ + +++ +E+ S K Sbjct: 870 SKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTL--------------REDLVSEK 915 Query: 1476 QAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDP 1535 QQ + ++ ++IG L+KE H ++ S D Sbjct: 916 ---LKTQQMNNDLEKLTHELEKIG-----------------LNKERLLHDEQ---STDDR 952 Query: 1536 HDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQ--E 1593 + + ESK T+ + + K++ ++ +E S + ++QL ++L+ +++ E Sbjct: 953 YKLLESK-LESTLKKSLEIKEEKIAALEARLEE----STNYNQQL---RQELKTVKKNYE 1004 Query: 1594 LVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERE 1653 ++Q Q+ ++ + + +RE QE +E +K +R + +N L +E++ Sbjct: 1005 ALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVER--NNATLQAEKQ 1062 Query: 1654 --RVLLEELEALK-----QLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQTFKEKELD 1706 + L++LE Q+ R+ + + +N++ QTQN + +VE T + Sbjct: 1063 ALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNA---KLQVENSTLNSQSTS 1119 Query: 1707 RKPED----VPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSK 1762 ++ + L NE ++ K L + ++K +E L + Sbjct: 1120 LMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLE----------LLHERQ 1169 Query: 1763 SQSSASLIWRSEAEASVKSCVHEEHTRVTD--ESIPSYSGSDMPRNDINMWSKVTEEGTE 1820 + SLI + S + EH + D + G D+ KV +E Sbjct: 1170 ASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQ---LEDLEKMLKVEQEKML 1226 Query: 1821 LSQRLVRSGFAG-TEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTEL- 1878 L + + A ++ EN+ L + S+L E L S L ++K+ QT L Sbjct: 1227 LENKNHETVAAEYKKLCGENDRLN-HTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLE 1285 Query: 1879 -----MRESFRQKQEATESLKCQ----EELRERLHEESR-AREQLAVELSKAEGVIDGYA 1928 ++E ++Q + L Q +L+ L EE+R +Q+ + + +++ Sbjct: 1286 AEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNM 1345 Query: 1929 DEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQE 1971 + K LF E+ ID+L EL +L+E +Q + + Sbjct: 1346 ESKDLFH---VEQRQYIDKL-NELRRQKEKLEEKIMDQYKFYD 1384 Score = 78.6 bits (192), Expect = 1e-13 Identities = 169/742 (22%), Positives = 317/742 (42%), Gaps = 101/742 (13%) Query: 2993 MQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTALGTTDAVGL 3052 +Q Q++ E + Q + D + + +Q+V + +V + E+T + D L Sbjct: 133 VQCQKKEEFIERIQGLDF--DTKAAVAAHIQEVTHNQENVFDLQWM-EVTDMSQEDIEPL 189 Query: 3053 LNC----LEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEK 3108 L L++ I E+ + +E ++ D L + AQ +KR + + Sbjct: 190 LKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASS-SAQSPCGSPGMKRTESRQH 248 Query: 3109 PSQEL---------LEYNIQQKQSQMLEMQVELSSMKDRATELQEQ-------------- 3145 S EL L +++K Q+L+ + EL M+ LQ++ Sbjct: 249 LSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMY 308 Query: 3146 ------LSSEKMVVAELKSELAQTKLELETT--LKAQHKHLKELEAFRLEVKDKTDEVHL 3197 L + + V +L+SE+++ K L KA+ + LKE LE K + Sbjct: 309 RDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKT------M 362 Query: 3198 LNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQL---NLL 3254 L D L + +S +L LEKE +L K +L D++ + +++ +L N+ Sbjct: 363 LEDQLEGTRARSDKLH-ELEKENLQL-------KAKLHDMEMERDMDRKKIEELMEENMT 414 Query: 3255 LEQ-QKQLLNES-QQKIESQRMLYDAQLSEEQGRNL--ELQVLLESEKVRIREMSSTLDR 3310 LE QKQ ++ES E +++ ++LSE ++L E+ L S +++ + +L + Sbjct: 415 LEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTK 474 Query: 3311 E-RELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQT- 3368 EL + S +G + E+ + L K++E + IV+ EK L + Q Sbjct: 475 TVEELRTTVDSVEGNASKILKMEKEN--QRLSKKVEILENEIVQ-----EKQSLQNCQNL 527 Query: 3369 RQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRL 3428 + + K++ KT++T +E N+E Q K+ L+ + E L + + RQ+ Sbjct: 528 SKDLMKEKAQLEKTIETLRE-NSERQIKI--LEQENEHLNQTVSSLRQR----------- 573 Query: 3429 QGIMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYA 3488 I E + +++E+E K IL++++ E T+ L+ +++++E ++ A Sbjct: 574 SQISAEARVKDIEKENK-----ILHESIKE-TSSKLSKIEFEKRQIKKELEHYKEKGERA 627 Query: 3489 KLIEMNGGGTGCNHELEMIRQK---LQCVASKLQVLPQKASERLQFETADDEDFIWVQEN 3545 + E+ E E++++K L+ K++ L Q+ SE L+ E + + +N Sbjct: 628 E--ELENELHHLEKENELLQKKITNLKITCEKIEALEQENSE-LERENRKLKKTLDSFKN 684 Query: 3546 IDEIILQLQKLTGQQGEEPSLVS---PSTSCGSL-TERLLRQNAELTGHISQLTEEKNDL 3601 + + L+K Q EE + S C S+ +L +N EL QL + L Sbjct: 685 LTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELL 744 Query: 3602 RNMVMKLEEQIRWYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRA 3661 + K E Y+ + N I+ + SE + E TLQK+L+ Sbjct: 745 KASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQ-LESELQDLEMENQTLQKNLEEL 803 Query: 3662 EAEVYKL-KAELRNDSLLQTLS 3682 + +L + E N SL Q S Sbjct: 804 KISSKRLEQLEKENKSLEQETS 825 >gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sapiens] Length = 1843 Score = 166 bits (420), Expect = 4e-40 Identities = 294/1277 (23%), Positives = 546/1277 (42%), Gaps = 185/1277 (14%) Query: 183 VTYGTEGLQQLQEFEAAIKQRDGI---ITQLTANLQQARREKDETMREFLELTEQSQKLQ 239 VT+ E + LQ E ++ I + + +L++ E+DE +EL+E+ L Sbjct: 163 VTHNQENVFDLQWMEVTDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLH 222 Query: 240 IQFQQLQASET-------LRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKE 292 ++++ R + + +L AK +I +Q+LEE+ L D +++ E Sbjct: 223 FLPHASSSAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELE 282 Query: 293 DFTMQISFLQEK----------IKVYEMEQDK------KVENSNKEEIQEKETI------ 330 +++ LQ++ ++Y E D +V+ E + KE + Sbjct: 283 QMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFY 342 Query: 331 ---IEEL--NTKIIEEEKKTLE--LKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNS 383 +EEL + +++ E K LE L+ +DK L EL+++ +Q ++ +M++E Sbjct: 343 KARVEELKEDNQVLLETKTMLEDQLEGTRARSDK-LHELEKENLQLKAKLHDMEME---- 397 Query: 384 KQKERQSSEEIKQLMGTVEELQKRNHKDS---QFETDIVQRMEQETQRKLEQLRAELDEM 440 + +R+ EE+ + T+E QK++ +S +E + + R + ++ + L E++E+ Sbjct: 398 RDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNEL 457 Query: 441 YGQQIVQMKQELIRQHMAQ-MEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELN 499 ++++++ E Q + + +EE++T NA + N+ K + + NE+ Sbjct: 458 TSSRLLKLEME--NQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIV 515 Query: 500 IKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLN 559 + Q + + K+ +++EK L++ +E L RE +R + + ++ LN Sbjct: 516 QEKQSLQNCQNLSKD----LMKEKAQLEKTIETL-------RENSERQIKILEQENEHLN 564 Query: 560 EAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRM----- 614 + SL + AE + KE ++ HE+ + KL +E EK + + Sbjct: 565 QTVSSLRQRSQISAE-ARVKDIEKENKILHES-IKETSSKLSKIEFEKRQIKKELEHYKE 622 Query: 615 ----AESQEAELERL--RTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQID 668 AE E EL L +LL L E +E + N E ++N + K+ +D Sbjct: 623 KGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKL--KKTLD 680 Query: 669 GLQNEMSQ----KIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINEL 724 +N Q + E Q +++NL ++N L+ + +K Q L N +E+ + +L Sbjct: 681 SFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLEN---KELESEKEQL 737 Query: 725 QKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEK 784 +K +E+L+ K+ LE Q L ++ + L+K ++ +Q QLE+E L+ E Sbjct: 738 KKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQ----QLESELQDLEMEN 793 Query: 785 KTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIE 844 +TL+ L E L I SK + + EKE + L +E L++ QL +E + Sbjct: 794 QTLQKNL---------EEL----KISSKRLEQL-EKENKSLEQETSQLEKDKKQLEKENK 839 Query: 845 KQRNTFSFAEKNFE---VNYQELQEEYACLLK-VKDDLEDSKNKQELEYKSKLKALNEEL 900 + R + E V L++E L K + E +ELE ++K + Sbjct: 840 RLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATI 899 Query: 901 HLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLS 960 ++ T V ++ + E +T +M +EK T EL EK+ + K L Q Sbjct: 900 DIK----TLVTLREDLVSEK----LKTQQMNNDLEKLTHEL-EKIGLNKERLLHDEQSTD 950 Query: 961 DLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLL 1020 D +L + E + KSL+ ++E+++ LE N+N Q ++ ++ Sbjct: 951 DSRYKLLESKLESTL----KKSLEIKEEKIAALEARLEESTNYN-----QQLRQELKTVK 1001 Query: 1021 DGVVTMTSR-GAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVT 1079 + R E V GE++K E + E +++ + D L V Sbjct: 1002 KNYEALKQRQDEERMVQSSPPISGEDNKWERESQ---------ETTRELLKVKDRLIEVE 1052 Query: 1080 KESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEA-QRICLSL-VYSTHVD------QV 1131 + + AT +E L+ +L L+++ N+L+ Q+ A QR +SL +T + QV Sbjct: 1053 RNN---ATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQV 1109 Query: 1132 REYMENEKDKALCSLKEELIFAQ-------EEKIKELQKIHQLELQTMKTQETGDEGKPL 1184 N + +L + +L+ Q E IKE + + L +K E Sbjct: 1110 ENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHE-------- 1161 Query: 1185 HLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQD 1244 KL+ + S + ++L S G + EV D E+ + + + + +L+D Sbjct: 1162 -----KLELLHERQASEY-ESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKG-QLED 1214 Query: 1245 YRYEVQDFQENMHTLLNK----VTEEYNKLLVLQTRLSKIWGQ--------QTDGMKLEF 1292 ++ QE M L NK V EY KL RL+ + Q QTD L+ Sbjct: 1215 LEKMLKVEQEKM-LLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKS 1273 Query: 1293 GEENLPKEET----EFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLIS 1348 N E+T EF + Q L+ ++ L L K LEE+ + L I Sbjct: 1274 LLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQL-KGNLEEENRHLLDQIQ 1332 Query: 1349 SLQQQLKE-TEQNYEAE 1364 +L Q + EQN E++ Sbjct: 1333 TLMLQNRTLLEQNMESK 1349 Score = 154 bits (390), Expect = 1e-36 Identities = 274/1258 (21%), Positives = 551/1258 (43%), Gaps = 189/1258 (15%) Query: 152 DSPTHLEMMESELAGKQHEIEELNRELEEMRVTYGTEGL----QQLQEFEAAIKQRDGII 207 +S HL + ELA + +I L +ELEE TE L Q+L++ E +K+ Sbjct: 244 ESRQHLSV---ELADAKAKIRRLRQELEEK-----TEQLLDCKQELEQMEIELKRLQQEN 295 Query: 208 TQLTANLQQARREKDETMREFLELTEQSQKLQIQFQQLQASETLRN-STHSSTAADLLQA 266 L ++ + AR +DE + E + KL+ + + + E L + + + +L + Sbjct: 296 MNLLSDARSARMYRDE-LDALREKAVRVDKLESEVSRYK--ERLHDIEFYKARVEELKED 352 Query: 267 KQQILTHQQQLEEQDHLLEDYQKKKEDF-TMQISFLQEKIKVYEMEQDKKVENSNKEEIQ 325 Q +L + LE+Q LE + + + ++ LQ K K+++ME ++ ++ EE+ Sbjct: 353 NQVLLETKTMLEDQ---LEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELM 409 Query: 326 EKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKN---MKLELTN 382 E+ +E + ++E ++++ +L Q+ + + E+ + +KLE+ N Sbjct: 410 EENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMEN 469 Query: 383 SKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYG 442 + ++ +++L TV+ ++ K + +ME+E QR +++ E+ Sbjct: 470 -----QSLTKTVEELRTTVDSVEGNASK--------ILKMEKENQRLSKKV-----EILE 511 Query: 443 QQIVQMKQELIRQHMAQMEEMKTRHKGEMENALR-----SYSNITVNEDQIKLMNVAINE 497 +IVQ KQ L Q+ + + + K ++E + S I + E + + +N ++ Sbjct: 512 NEIVQEKQSL--QNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSS 569 Query: 498 LNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESK 557 L + Q + + K E+ IL E ++ + ++ F + QI++ + E+ + Sbjct: 570 LRQRSQISAEARVKDIEKENKILHESI---KETSSKLSKIEFEKRQIKKELEHYKEKGER 626 Query: 558 LNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLE--KEKNAVLDRMA 615 E L +E KE EL + ++TN KI E +E +++N+ L+R Sbjct: 627 AEELENELHHLE-------------KENELLQK-KITNLKITCEKIEALEQENSELEREN 672 Query: 616 ESQEAELERLR--TQLLFSHEEELSKLKEDLEIEHRINIEKLK------DNLGIHYKQQI 667 + L+ + T L S E+E S+L E+ +E R N+E LK L + K+ + Sbjct: 673 RKLKKTLDSFKNLTFQLESLEKENSQLDEE-NLELRRNVESLKCASMKMAQLQLENKE-L 730 Query: 668 DGLQNEMSQKIETMQ--FEK-DNLITKQNQLILEISKL--------KDLQQSLVNSKSEE 716 + + ++ + +E ++ F+K + L L +E +L K +QQ + S+ ++ Sbjct: 731 ESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQ--LESELQD 788 Query: 717 MTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAE 776 + ++ LQK +E L+ K LE+E + L+ +T LEK K+ E + + Q E + Sbjct: 789 LEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIK 848 Query: 777 NSILKDEKKTLEDMLKIHTPVSQE-----ERLIFLDSIKSKSKDSVWEKEIEI--LIEEN 829 ++ L++ + ++ K + +S+E E + L ++ ++K+ V I+I L+ Sbjct: 849 DTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLR 908 Query: 830 EDL---KQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQE 886 EDL K + Q+N ++EK + N E + Q K+ + +S K+ Sbjct: 909 EDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKS 968 Query: 887 LEYK-SKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVA-ETLEMGEVVEKDTTELMEK 944 LE K K+ AL E L+ +++ + K + A + + E + + + + + Sbjct: 969 LEIKEEKIAAL--EARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGE 1026 Query: 945 LEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHN 1004 +RE E ++ L + ++L + + L E ++LK + +Q+ + N+N Sbjct: 1027 DNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQ--------NNN 1078 Query: 1005 RAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEE 1064 + + Q SL + T+ ++ A K+ EN T+ + Sbjct: 1079 LQAQILALQRQTVSLQEQNTTLQTQNA---------------------KLQVENSTLNSQ 1117 Query: 1065 SKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKS-------EQNDLRLQMEAQR 1117 S L+ + + ++SSL +EN+ + KE LKS + L L E Q Sbjct: 1118 S--TSLMNQNAQLLIQQSSLE----NENESVIKEREDLKSLYDSLIKDHEKLELLHERQA 1171 Query: 1118 ICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQET 1177 + S H + E + + + Q+ ++++L+K+ ++E + M Sbjct: 1172 SEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKM----- 1226 Query: 1178 GDEGKPLHLLIGKLQKAVSEECSYFLQTLCSV---LGEYYTPALK-CEVNAEDKENSGDY 1233 LL K + V+ E + LC L Y+ LK EV D +N Sbjct: 1227 --------LLENKNHETVAAE----YKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSL 1274 Query: 1234 ISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFG 1293 ++ + +L+ R E + +K+ E+Y +L + T+L+ + +K Sbjct: 1275 LNNS---KLEQTRLEAE---------FSKLKEQYQQLDITSTKLNN-QCELLSQLKGNLE 1321 Query: 1294 EEN---LPKEETEFLSIHSQM-TNLEDIDVNH---KSKLSSLQDL--EKTKLEEQVQE 1342 EEN L + +T L + + N+E D+ H + + L +L +K KLEE++ + Sbjct: 1322 EENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMD 1379 Score = 149 bits (375), Expect = 7e-35 Identities = 309/1457 (21%), Positives = 596/1457 (40%), Gaps = 234/1457 (16%) Query: 1929 DEKTLFERQIQEKTDI----IDRLEQELLCASNRLQELEAEQQQ----IQEERELLSRQK 1980 +++ +F+ Q E TD+ I+ L + + RL + E + + EER+ L Sbjct: 166 NQENVFDLQWMEVTDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLP 225 Query: 1981 EAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIEL 2040 A + P ++ TE +E+ D + +++ L ++EE+ + ++ Sbjct: 226 HASSSAQSPCGSPGMKRTESRQHLSVELA--------DAKAKIRRLRQELEEKTEQLLDC 277 Query: 2041 EQE---KNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVV 2097 +QE EL L+Q+N L R + DE +D E+ V + KLE + V Sbjct: 278 KQELEQMEIELKRLQQENMNLLSDARSARMYRDE--LDALREKAV---RVDKLESE---V 329 Query: 2098 PRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELE 2157 R++ + ++E ++E + LL +K L+ ++ +KL ELE Sbjct: 330 SRYK----ERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLH----ELE 381 Query: 2158 QALLVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEE 2217 K L L+ +L D K+I L E E E+ K Sbjct: 382 ----------------KENLQLKAKLHDMEMERDMDRKKIEELME--ENMTLEMAQKQSM 423 Query: 2218 VQQLHMQLEIQKKESTTRLQELEQEN-----------KLFKDDMEKLGLAIKESDAMSTQ 2266 + LH+ E+++ T+ L E Q++ +L K +ME L + +T Sbjct: 424 DESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTV 483 Query: 2267 DQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECL 2326 D + G ++I++ E E +L+++V L+ + I + + ++ L +DL + L Sbjct: 484 DS--VEGNASKILK-MEKENQRLSKKVEILENE--IVQEKQSLQNCQNLSKDLMKEKAQL 538 Query: 2327 MSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAE 2386 E ++ N E +I+ L + E L Q ++++ Q++ ++A + ++ + L I E Sbjct: 539 EKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKE 598 Query: 2387 KLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVA 2446 + ++E ++ KE + +L EL L++E E ++K Sbjct: 599 TSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQK-----------K 647 Query: 2447 IDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLE 2506 I +L ++E + E++ EN+ K+ + S NL +L LE S D E Sbjct: 648 ITNLKITCEKIEALEQENSELERENRKLKKTLD-----SFKNLTFQLESLEKENSQLDEE 702 Query: 2507 LTQCYKQIKDMQ------EQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYA 2560 + + ++ ++ Q Q E + L+ + L+K +E + A+ +LE Y Sbjct: 703 NLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLE-LLKASFKKTERLEV--SYQ 759 Query: 2561 KFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQ 2620 +NQ + E +N + + QL + L+ E+E+Q ++ + E+ Sbjct: 760 GLDIENQRLQKTLENSN-KKIQQLESE----------LQDLEMENQTLQKNL------EE 802 Query: 2621 VEIAEKNV--LEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESG 2678 ++I+ K + LEKE K LE + +KKQ EKE KR Q E+ TT E +N + G Sbjct: 803 LKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLE--ENNVKIG 860 Query: 2679 FFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEK 2738 L E+ E+ YKE +L+E Sbjct: 861 ------NLEKENKTLSKEIGIYKESCVRLKE----------------------------- 885 Query: 2739 LSILEKEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQI 2798 LEKE++ V K+A + + L + + S+ T ++ +N ++ + I + Sbjct: 886 ---LEKENKELV---KRATIDIKTLVTLREDLVSEKLKTQQM--NNDLEKLTHELEKIGL 937 Query: 2799 NLQSECSSEEVTEIISQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLLKE 2858 N + E+ T+ + +E E + L+++ I+ E E Q L++ Sbjct: 938 NKERLLHDEQSTD--DSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQ 995 Query: 2859 ECGTLKAVIQCLRSKEG-----SSIPELAHSDAYQTREICSSDSGSDWGQGIYLTHSQGF 2913 E T+K + L+ ++ S P ++ D RE S ++ + L + Sbjct: 996 ELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERE--SQETTRE------LLKVKDR 1047 Query: 2914 DIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWL 2973 I E ++ + ++K L +N Q+L+L S L Sbjct: 1048 LIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVS--------------L 1093 Query: 2974 EERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVL 3033 +E+ + T ++ + +V +S+ + +S S L +QQ LE + Sbjct: 1094 QEQNTTLQTQNA------------KLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENES 1141 Query: 3034 LAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQM 3093 + R +L +L + LE + Q EY++ + + +S ++ H + Sbjct: 1142 VIKEREDLKSL-YDSLIKDHEKLELLHERQASEYESLIS--KHGTLKSAHKNLEVEHRDL 1198 Query: 3094 NGRKITLKREQESEKPSQELLEYN-----IQQKQSQMLEMQV-ELSSMKDRATELQEQLS 3147 R L +++ + +++L+ ++ K + + + +L DR QL Sbjct: 1199 EDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLL 1258 Query: 3148 SEKMVV----AELKSELAQTKLELETTLKAQHKHLKE-LEAFRLEVKDKTDEVHLLNDTL 3202 E V+ LKS L +KLE +T L+A+ LKE + + ++ LL+ Sbjct: 1259 KETEVLQTDHKNLKSLLNNSKLE-QTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLK 1317 Query: 3203 ASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLL 3262 + ++++R L L++ + + ++ ++ +E Q+Q +LN L Q+++L Sbjct: 1318 GNLEEENRHL---LDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKL- 1373 Query: 3263 NESQQKIESQRMLYDAQLSEEQGR--NLELQVLLESEK--VRIREMSSTLDRERELHAQL 3318 ++KI Q YD +G L+++ L++S+K R R+ S TL R Sbjct: 1374 ---EEKIMDQYKFYDPSPPRRRGNWITLKMRKLIKSKKDINRERQKSLTLTPTRS----- 1425 Query: 3319 QSSDGTGQSRPPLPSED 3335 SS+G Q LP +D Sbjct: 1426 DSSEGFLQ----LPHQD 1438 Score = 145 bits (366), Expect = 8e-34 Identities = 301/1356 (22%), Positives = 584/1356 (43%), Gaps = 219/1356 (16%) Query: 1427 NIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQ----QTELSRISGGKENTASSKQAHAVCQ 1482 N++ + + + EQ EEV K+++ + Q + + RI G +T ++ AH Sbjct: 104 NVLIIGKNPFSEQGTEEVKKLLLLLLGCAVQCQKKEEFIERIQGLDFDTKAAVAAH---- 159 Query: 1483 QEQHYFNEMKLSQDQI-GFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPH----- 1536 E+ +Q+ + Q E D+ +E+ +PL K + H K L+ D H Sbjct: 160 -----IQEVTHNQENVFDLQWMEVTDMS-QEDIEPLLKNMALHLKR-LIDERDEHSETII 212 Query: 1537 DIPESKDCVLTISEEMFSKDKTF----IVRQSIHDEISVSSMDA--------------SR 1578 ++ E +D + + S + R +SV DA + Sbjct: 213 ELSEERDGLHFLPHASSSAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTE 272 Query: 1579 QLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLA 1638 QL+ +++LE M EL R QE+ R A M R++ + L+E+ R+++ + Sbjct: 273 QLLDCKQELEQMEIELKRLQQENMNLLSDARSARM-----YRDELDALREKAVRVDKLES 327 Query: 1639 QRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQ 1698 + S E + +EEL+ Q+ L + L +L + ++ +E + E + Sbjct: 328 EVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQL 387 Query: 1699 TFK------EKELDRKP-EDVPPEILSNERYALQKANNRL-----LKILLEVVKTTAAVE 1746 K E+++DRK E++ E ++ E Q + L L+ + + + A + Sbjct: 388 KAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQ 447 Query: 1747 ETIGRHV-------LGILDRSSKS---------------QSSASLIWRSEAE---ASVKS 1781 +++G V L L+ ++S + +AS I + E E S K Sbjct: 448 KSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKV 507 Query: 1782 CVHEEHTRVTDESIPSYS--GSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPEN 1839 + E +S+ + D+ + + K E E S+R ++ ++ EN Sbjct: 508 EILENEIVQEKQSLQNCQNLSKDLMKEKAQL-EKTIETLRENSERQIKI------LEQEN 560 Query: 1840 EELMLNISSRLQAA----------VEK----LLEAISETSSQLEHAKVTQTELMRESFRQ 1885 E L +SS Q + +EK L E+I ETSS+L + + ++ +E Sbjct: 561 EHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHY 620 Query: 1886 KQEATESLKCQEELRERLHEESRAREQLAVELSKAE---GVIDGYADEKTLFERQIQEKT 1942 K++ + EEL LH + E L +++ + I+ E + ER+ ++ Sbjct: 621 KEKGERA----EELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLK 676 Query: 1943 DIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLM 2002 +D + + +L+ LE E Q+ EE L R E++K A QL E ++L Sbjct: 677 KTLDSFKN----LTFQLESLEKENSQLDEENLELRRNVESLKC-ASMKMAQLQLENKELE 731 Query: 2003 KEKLEVQCQAEKVRDDLQK----QVKALEIDVEEQ-VSRFIELEQEK----NTELMDLRQ 2053 EK +++ E ++ +K +V +D+E Q + + +E +K +EL DL Sbjct: 732 SEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEM 791 Query: 2054 QNQALEK-------------QLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRF 2100 +NQ L+K QLEK K L+++ E ++ ++E ++L QQ ++ + Sbjct: 792 ENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEI--KD 849 Query: 2101 QPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQR--DIQERNEEIEK---LEFR-VR 2154 + E+ + + N KE E+ + KE R ++++ N+E+ K ++ + + Sbjct: 850 TTLEENNVK----IGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLV 905 Query: 2155 ELEQALLVEDRKHFGAVEAKPELSLEVQ---LQAERDAIDRKEKEITN---LEEQLEQ-F 2207 L + L+ E K +L+ E++ L ER D + + + LE +LE Sbjct: 906 TLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTL 965 Query: 2208 REELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQD 2267 ++ LE K E++ L +LE EST Q+L QE K K + E L ++ + Q Sbjct: 966 KKSLEIKEEKIAALEARLE----ESTNYNQQLRQELKTVKKNYE--ALKQRQDEERMVQS 1019 Query: 2268 QHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQL-KITTDNKVIEEKNELIRDLETQIECL 2326 + G+ + E E + ++ K++ +L ++ +N ++ + + L+TQ++ L Sbjct: 1020 SPPISGE----DNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQA---LKTQLKQL 1072 Query: 2327 MSDQECVKRNREEEIEQLNEVIEKLQQE---LANIGQKTSMNAHSLSEEADSLKHQLDVV 2383 E N + +I L LQ++ L K + +L+ ++ SL +Q + Sbjct: 1073 ----ETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQL 1128 Query: 2384 IAEKLALEQQVETANEEMTFMKNV---LKETNFKMNQLTQELFSLKRERES-VEKIQSIP 2439 + ++ +LE + E+ +E +K++ L + + K+ L + S E ES + K ++ Sbjct: 1129 LIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQAS---EYESLISKHGTLK 1185 Query: 2440 ENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLES- 2498 N+ ++H + +++ + L+ LE ++ +E + LE+ Sbjct: 1186 SAHKNLEVEHRDLEDRYNQLLKQKGQLEDLE--------------KMLKVEQEKMLLENK 1231 Query: 2499 ---TVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEA 2555 TV+A+ +L ++ Q ETE+LQ NL+ ++ + + Q +LEA Sbjct: 1232 NHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNN----SKLEQTRLEA 1287 Query: 2556 VQEYAKFCQDNQTISSEPERTNIQ--NLNQLR---EDE---LGSDISALTLRISELESQV 2607 E++K + Q + + N Q L+QL+ E+E L I L L+ L Q Sbjct: 1288 --EFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQN 1345 Query: 2608 VEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLE 2643 +E +E+ Q I + N L ++K+ LE +K+++ Sbjct: 1346 MESKDLFHVEQRQY-IDKLNELRRQKEKLE-EKIMD 1379 Score = 145 bits (366), Expect = 8e-34 Identities = 245/1163 (21%), Positives = 478/1163 (41%), Gaps = 188/1163 (16%) Query: 1511 KEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDK----TFIVRQSIH 1566 K+E + + EL +E + SD +D + + E+ DK ++ +H Sbjct: 278 KQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLH 337 Query: 1567 D----EISVSSMDASRQLMLN-----EEQLEDMRQELVRQYQEHQQATELLRQAHMRQME 1617 D + V + Q++L E+QLE R + ++ ++ +L + H +ME Sbjct: 338 DIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEME 397 Query: 1618 RQ--REDQEQLQEEIKRLNRQLAQRSSIDNE-NLVSERERVL-LEELEALKQLSLA---- 1669 R R+ E+L EE + ++AQ+ S+D +L E E++ EL Q SL Sbjct: 398 RDMDRKKIEELMEE--NMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVN 455 Query: 1670 ---GREKLCCELRNSS---------TQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEIL 1717 L E+ N S T + N ++ + + + L +K E + EI+ Sbjct: 456 ELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIV 515 Query: 1718 SNERYALQKANNR---LLKILLEVVKTTAAVEETIGRHVLGILDRSSK--SQSSASLIWR 1772 E+ +LQ N L+K ++ KT + E R + IL++ ++ +Q+ +SL R Sbjct: 516 Q-EKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIK-ILEQENEHLNQTVSSLRQR 573 Query: 1773 SEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAG 1832 S+ A + E+ ++ ESI E S +L + F Sbjct: 574 SQISAEARVKDIEKENKILHESIK-----------------------ETSSKLSKIEFEK 610 Query: 1833 TEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATES 1892 +I E E ++ E E ++L H + + EL+++ + E Sbjct: 611 RQIKKELEHY------------KEKGERAEELENELHHLE-KENELLQKKITNLKITCEK 657 Query: 1893 LKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQEL 1952 ++ E+ L E+R ++ ++ E + Q+ E+ + R + L Sbjct: 658 IEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENS----QLDEENLELRRNVESL 713 Query: 1953 LCASNRLQELEAEQQQIQEERELLSRQKEAMKA------------EAGPVEQQLLQETEK 2000 CAS ++ +L+ E ++++ E+E L + E +KA + +E Q LQ+T + Sbjct: 714 KCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLE 773 Query: 2001 LMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQ--VSRFIELEQEKNTELMDLRQQNQAL 2058 +K++ Q E DL+ + + L+ ++EE S+ +E +++N L Q + Sbjct: 774 NSNKKIQ---QLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKD 830 Query: 2059 EKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHL 2118 +KQLEK K L +QA ++ + +I LE++ K + + I + +++L Sbjct: 831 KKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKEN 890 Query: 2119 KE---------------KTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVE 2163 KE + D SE L +Q+ D+++ E+EK+ L Sbjct: 891 KELVKRATIDIKTLVTLREDLVSE-KLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQST 949 Query: 2164 DRKHFGAVEAKPELSLEVQLQAERD---AIDRKEKEITNLEEQLEQFREELENKNEEVQQ 2220 D + +E+K E +L+ L+ + + A++ + +E TN +QL Q + ++ E ++Q Sbjct: 950 DDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQ 1009 Query: 2221 LH----------------MQLEIQKKEST-------TRLQELEQENKLFKDDMEKLGLAI 2257 + E + +E+T RL E+E+ N + + + L + Sbjct: 1010 RQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQL 1069 Query: 2258 KESDAMSTQDQHVLFGKFAQIIQEKE-------------VEIDQLNEQVTKL-QQQLKIT 2303 K+ + + Q + Q + +E VE LN Q T L Q ++ Sbjct: 1070 KQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLL 1129 Query: 2304 TDNKVIEEKNELI----RDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIG 2359 +E +NE + DL++ + L+ D E ++ E + + +I K L + Sbjct: 1130 IQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISK-HGTLKSAH 1188 Query: 2360 QKTSMNAHSLSEEADSL---KHQLD------VVIAEKLALE-QQVETANEEMTFMKNVLK 2409 + + L + + L K QL+ V EK+ LE + ET E + Sbjct: 1189 KNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGEND 1248 Query: 2410 ETNFKMNQLTQELFSLKRERESVEKI---QSIPENSVNVAIDHLSKDKPELEVVLTEDAL 2466 N +QL +E L+ + ++++ + + + + L + +L++ T+ Sbjct: 1249 RLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTK--- 1305 Query: 2467 KSLENQTYFKS-----FEENGKGSIINLETRLLQ----LESTVSAKDLELTQCYKQIKDM 2517 L NQ S EE + + ++T +LQ LE + +KDL + +Q D Sbjct: 1306 --LNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVE-QRQYIDK 1362 Query: 2518 QEQGQFETEMLQKKIVNLQKIVE 2540 + + + E L++KI++ K + Sbjct: 1363 LNELRRQKEKLEEKIMDQYKFYD 1385 Score = 134 bits (336), Expect = 2e-30 Identities = 206/989 (20%), Positives = 452/989 (45%), Gaps = 137/989 (13%) Query: 2 EDEERQKKLEAGKAKLAQFRQ--RKAQSDGQSPSKKQKKKRKTSSSKHDVSAHHDLNIDQ 59 E++ KK+E + ++ Q +Q + Q+ + K++ + KT + + S ++Q Sbjct: 499 ENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQ 558 Query: 60 SQCNEMYINSSQRVESTVIPESTIMRTLHSGEITSHEQGFSVELESEI-STTADDCSSEV 118 + SS R S + E+ + +E E++I + + SS++ Sbjct: 559 ENEHLNQTVSSLRQRSQISAEARVK---------------DIEKENKILHESIKETSSKL 603 Query: 119 NGCSFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHEIEELNREL 178 + F R K +E E Y E+G + E +E+EL + E E L +++ Sbjct: 604 SKIEFEKRQIK-----KELEH-----YKEKGER-----AEELENELHHLEKENELLQKKI 648 Query: 179 EEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKL 238 +++T ++ EA + Q + L++ R+ +T+ F LT Q + L Sbjct: 649 TNLKIT--------CEKIEA--------LEQENSELERENRKLKKTLDSFKNLTFQLESL 692 Query: 239 QIQFQQLQASET-LRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDF--T 295 + + QL LR + S A + A+ Q L +++ E++ L + + K F T Sbjct: 693 EKENSQLDEENLELRRNVESLKCASMKMAQLQ-LENKELESEKEQLKKGLELLKASFKKT 751 Query: 296 MQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELK-DKLTT 354 ++ + + + K +ENSNK+ IQ+ E+ +++L E E +TL+ ++L Sbjct: 752 ERLEVSYQGLDIENQRLQKTLENSNKK-IQQLESELQDL-----EMENQTLQKNLEELKI 805 Query: 355 ADKLLGELQEQ---IVQKNQEIKNMKLELTNSKQKERQSSE-------EIKQLMGTVEEL 404 + K L +L+++ + Q+ +++ K +L ++ RQ +E E +G +E+ Sbjct: 806 SSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKE 865 Query: 405 QKRNHKD-SQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEM 463 K K+ ++ V+ E E + K RA +D + +V ++++L+ E++ Sbjct: 866 NKTLSKEIGIYKESCVRLKELEKENKELVKRATIDI---KTLVTLREDLVS------EKL 916 Query: 464 KTRH-KGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEE 522 KT+ ++E I +N++++ + ++ KL ++ + LK+ L I EE Sbjct: 917 KTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLEST-LKKSLE-IKEE 974 Query: 523 KCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESR 582 K A LE +EE + +Q+++ +T+ + L + V+ + +S +++ Sbjct: 975 KIAA---LEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQS--SPPISGEDNK 1029 Query: 583 KELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKE 642 E E E K+K ++E E+N + +AE + L+TQL E + + L+ Sbjct: 1030 WERE-SQETTRELLKVKDRLIEVERNNA------TLQAEKQALKTQLK-QLETQNNNLQA 1081 Query: 643 DLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKL 702 + R + + N + + Q LQ E S T+ + +L+ + QL+++ S L Sbjct: 1082 QILALQRQTVSLQEQNTTL--QTQNAKLQVENS----TLNSQSTSLMNQNAQLLIQQSSL 1135 Query: 703 KDLQQSLVNSKSEEMTLQINELQ--KEIEILRQEEKEK--------GTLEQEVQELQLKT 752 ++ +S++ + + +L + ++ +++E+L + + + GTL+ + L+++ Sbjct: 1136 ENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVE- 1194 Query: 753 ELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSK 812 + ++++ N L ++ QLE +LK E++ + K H V+ E + + ++ + Sbjct: 1195 ---HRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLN 1251 Query: 813 SKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLL 872 S KE E+L ++++LK + N ++E+ R E + +L+E+Y L Sbjct: 1252 HTYSQLLKETEVLQTDHKNLKS--LLNNSKLEQTR---------LEAEFSKLKEQYQQL- 1299 Query: 873 KVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGE 932 D+ +K + E S+LK +L+ N + ++ +++T + + +E + Sbjct: 1300 ----DITSTKLNNQCELLSQLKG-----NLEEENRHLLDQIQTLMLQNRTLLEQNMESKD 1350 Query: 933 VVEKDTTELMEKLEVTKREKLELSQRLSD 961 + + + ++KL +R+K +L +++ D Sbjct: 1351 LFHVEQRQYIDKLNELRRQKEKLEEKIMD 1379 Score = 110 bits (275), Expect = 3e-23 Identities = 174/834 (20%), Positives = 354/834 (42%), Gaps = 114/834 (13%) Query: 2 EDEERQKKLEAGKAKLAQFRQRKAQSDGQSPSKKQKKKRKTSSSKHDVSAHHDLNIDQSQ 61 E+E QKK+ K + + Q + + + +K K+ S K+ L + SQ Sbjct: 640 ENELLQKKITNLKITCEKIEALE-QENSELERENRKLKKTLDSFKNLTFQLESLEKENSQ 698 Query: 62 CNEMYINSSQRVESTVIPESTIMRTLHSGEITSHEQGFSVELESEISTTADDCSSEVNGC 121 +E + + VES + + Q + ELESE G Sbjct: 699 LDEENLELRRNVESLKCASMKMAQL----------QLENKELESEKEQLK-------KGL 741 Query: 122 SFVMRTGKPTNLLREEEFGVD--DSYSEQGAQDSPTHLEMMESELAGKQHEIEELNRELE 179 + + K T L G+D + ++ ++S ++ +ESEL + E + L + LE Sbjct: 742 ELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLE 801 Query: 180 EMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQ 239 E++++ ++ L+QL++ +++Q Q ++K + +E L +Q++ Sbjct: 802 ELKIS--SKRLEQLEKENKSLEQ----------ETSQLEKDKKQLEKENKRLRQQAEIKD 849 Query: 240 IQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQ-KKKEDFTMQI 298 ++ + + + ++ K+ + ++ +E L++ K T++ Sbjct: 850 TTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLRE 909 Query: 299 SFLQEKIKVYEMEQD-KKVENS------NKEEIQEKETIIEELNTKIIEEE-----KKTL 346 + EK+K +M D +K+ + NKE + E ++ K++E + KK+L Sbjct: 910 DLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSL 969 Query: 347 ELK-DKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQ 405 E+K +K+ + L E Q QE+K +K KQ RQ E + Q + Sbjct: 970 EIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQ--RQDEERMVQSSPPI---- 1023 Query: 406 KRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKT 465 + +D+++E R QET R+L +++ L E + ++ A ++ K Sbjct: 1024 --SGEDNKWE-----RESQETTRELLKVKDRLIE-------------VERNNATLQAEKQ 1063 Query: 466 RHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCA 525 K +++ +N+ ++ V++ E N LQ +Q KL+ E + + + Sbjct: 1064 ALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQ---TQNAKLQVENSTLNSQSTS 1120 Query: 526 LQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKEL 585 L Q Q + +Q S NE + EDLK+ S + ++L Sbjct: 1121 LMNQ-----------------NAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKL 1163 Query: 586 ELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLE 645 EL HE + + Y+ + K+A + E + +LE QLL + +L L++ L+ Sbjct: 1164 ELLHERQASEYESLISKHGTLKSA--HKNLEVEHRDLEDRYNQLL-KQKGQLEDLEKMLK 1220 Query: 646 IEHRINI--EKLKDNLGIHYKQ------QIDGLQNEMSQKIETMQFEKDNLITKQNQLIL 697 +E + K + + YK+ +++ +++ ++ E +Q + NL + N L Sbjct: 1221 VEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKL 1280 Query: 698 EISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQ-----EEKEKGTLEQEVQELQLKT 752 E ++L + + S + + +++ + +L + E+L Q EE+ + L+Q +Q L L+ Sbjct: 1281 EQTRL-EAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQ-IQTLMLQN 1338 Query: 753 E-LLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLE---DMLKIHTPVSQEER 802 LLE+ M+ K+ E+ ++ N + + ++K E D K + P R Sbjct: 1339 RTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQYKFYDPSPPRRR 1392 Score = 101 bits (251), Expect = 2e-20 Identities = 249/1188 (20%), Positives = 469/1188 (39%), Gaps = 260/1188 (21%) Query: 2618 KEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEES 2677 K ++ + + EK ++LL+ ++ LE Q E E KR Q+ L L + Sbjct: 257 KAKIRRLRQELEEKTEQLLDCKQELE-----QMEIELKRLQQENMNL-----LSDARSAR 306 Query: 2678 GFFNELEALRAESVAT---KAELASYKEK----------AEKLQEELLVKETNMTSLQKD 2724 + +EL+ALR ++V ++E++ YKE+ E+L+E+ V T L+ Sbjct: 307 MYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQ 366 Query: 2725 LSQVR---DHLAEA-KEKLSILEKEDETEVQESKKACMFEPLP---IKLSKSIASQTDGT 2777 L R D L E KE L + K + E++ E L + L + D + Sbjct: 367 LEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDES 426 Query: 2778 L-------KISSSNQTPQILVKNAGIQIN-------LQSECSSEEVTEIISQFTEKIEKM 2823 L +IS +++ + K+ G ++N L+ E ++ +T+ + + ++ + Sbjct: 427 LHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSV 486 Query: 2824 QELHAAEILDMESRH--------------ISETETLKREHYVAVQLLKEECGTLKAVIQC 2869 E +A++IL ME + + E ++L+ ++ L+KE+ L+ I+ Sbjct: 487 -EGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKA-QLEKTIET 544 Query: 2870 LRSKEGSSIPELAHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESESATD 2929 LR I L + + + + S S I++E R ++ E Sbjct: 545 LRENSERQIKILEQENEHLNQTVSSLRQRSQ--------------ISAEARVKDIEKENK 590 Query: 2930 SFPKKIK---GLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINT-ISS 2985 + IK L + E Q+ E GE + LE+ + I++ Sbjct: 591 ILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITN 650 Query: 2986 LKDLITKMQL--QREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTA 3043 LK K++ Q +E+ ++ + D L L+ LE+ + L EL Sbjct: 651 LKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLES--LEKENSQLDEENLELRR 708 Query: 3044 LGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADR--RSLLSEIQALHAQMNGRKITLK 3101 +++ + ++Q + E ++ E L+K ++ + + L G I + Sbjct: 709 --NVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQ 766 Query: 3102 REQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQ------EQLSSEKMVVAE 3155 R Q++ + S + IQQ +S++ ++++E +++ EL+ EQL E + + Sbjct: 767 RLQKTLENSNK----KIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQ 822 Query: 3156 LKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLL--------NDTLASE-- 3205 S+L + K +LE ++K L++ + E+KD T E + + N TL+ E Sbjct: 823 ETSQLEKDKKQLEK----ENKRLRQ----QAEIKDTTLEENNVKIGNLEKENKTLSKEIG 874 Query: 3206 -QKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQ------- 3257 K+S LEKE +L + D + L L+ L S+K + Q+N LE+ Sbjct: 875 IYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEK 934 Query: 3258 ----QKQLLNESQQKIESQRMLYDAQLSEEQGRNLE--------LQVLLESE---KVRIR 3302 +++LL++ Q +S+ L +++L ++LE L+ LE ++R Sbjct: 935 IGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLR 994 Query: 3303 EMSSTLDRERELHAQLQSSDGTGQSRPPLPSED-------------LLKELQKQLE-EKH 3348 + T+ + E Q Q + QS PP+ ED LLK + +E E++ Sbjct: 995 QELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERN 1054 Query: 3349 SRIVELLNETEKYKLDSLQTR-----------QQMEKDRQVHRKTLQTE----------- 3386 + ++ + K +L L+T+ Q+ Q TLQT+ Sbjct: 1055 NATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTL 1114 Query: 3387 ----------------QEANTEGQ-----KKMHELQSKVEDL-----------QRQLEE- 3413 Q+++ E + K+ +L+S + L +RQ E Sbjct: 1115 NSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEY 1174 Query: 3414 --------------KRQQVYKLDLEGQRLQGIMQEFQKQELEREEKRESRRILYQNLNEP 3459 K +V DLE + Q + Q+ Q ++LE+ K E ++L +N N Sbjct: 1175 ESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNH- 1233 Query: 3460 TTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMIRQKLQCVASKLQ 3519 ET + Y KL G NH + ++ + + + + Sbjct: 1234 ---------------------ETVAAEYKKLC---GENDRLNHTYSQLLKETEVLQTDHK 1269 Query: 3520 VLPQKASERLQFETADDEDFIWVQENIDEIILQLQKLTGQ-----------QGEEPSLVS 3568 L + +T + +F ++E ++ + KL Q + E L+ Sbjct: 1270 NLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLD 1329 Query: 3569 PSTSCGSLTERLLRQNAELTG--HIS--QLTEEKNDLRNMVMKLEEQI 3612 + LL QN E H+ Q ++ N+LR KLEE+I Sbjct: 1330 QIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKI 1377 Score = 98.6 bits (244), Expect = 1e-19 Identities = 249/1199 (20%), Positives = 508/1199 (42%), Gaps = 164/1199 (13%) Query: 651 NIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLV 710 +IE L N+ +H K+ ID ++E S+ I + E+D L + S Sbjct: 185 DIEPLLKNMALHLKRLIDE-RDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGMKRT 243 Query: 711 NSKSEEMTLQINELQKEIEILRQEEKEKGT----LEQEVQELQLKTELLEKQMKEKENDL 766 S+ + +++++ + + +I LRQE +EK +QE+++++++ + L+++ +D Sbjct: 244 ESR-QHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDA 302 Query: 767 QEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQ-EERLIFLDSIKSKSKDSVWEKEIEIL 825 + A++ + EK D K+ + VS+ +ERL ++ K++ +E L Sbjct: 303 RS--ARMYRDELDALREKAVRVD--KLESEVSRYKERLHDIEFYKAR---------VEEL 349 Query: 826 IEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQ 885 E+N+ L + L +++E R + ++K E+ + LQ +K L D + ++ Sbjct: 350 KEDNQVLLETKTMLEDQLEGTR---ARSDKLHELEKENLQ--------LKAKLHDMEMER 398 Query: 886 ELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKL 945 +++ K + + E + L+ ++ +S + ++ T E+ E +K + +L Sbjct: 399 DMDRKKIEELMEENMTLEMAQKQSMD-ESLHLGWELEQISRTSELSEAPQKSLGHEVNEL 457 Query: 946 EVTKREKLEL-SQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINH- 1003 ++ KLE+ +Q L+ E+L+ + K LK EKE L +++EI+ N Sbjct: 458 TSSRLLKLEMENQSLTKTVEELRTTVDSVE--GNASKILKMEKENQRLS-KKVEILENEI 514 Query: 1004 -NRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVG 1062 +++Q+C L+ + E ++ + ++ + KI+ ++ N TV Sbjct: 515 VQEKQSLQNCQNLSKDLMKEKAQL-----EKTIETLRENSERQIKILEQENEHL-NQTVS 568 Query: 1063 EESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSL 1122 ++ Q ++ E+ ++ + EN L + + S+ + +++ E ++I L Sbjct: 569 SLRQRSQ--------ISAEARVKDIE-KENKILHESIKETSSKLS--KIEFEKRQIKKEL 617 Query: 1123 VYSTHVDQVREYMENE-----KDKALCSLKEELIFAQEEKIKEL-QKIHQLELQTMKTQE 1176 + + E +ENE K+ L K + EKI+ L Q+ +LE + K ++ Sbjct: 618 EHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKK 677 Query: 1177 TGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISE 1236 T D K L + L+K S+ L+ +V ++ E+KE + Sbjct: 678 TLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQL 737 Query: 1237 NEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEEN 1296 + EL ++ + E + L+ + K L+ KI +++ LE + Sbjct: 738 KKGLELLKASFKKTERLEVSYQGLDIENQRLQK--TLENSNKKIQQLESELQDLEMENQT 795 Query: 1297 LPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKE 1356 L K NLE++ ++ K +L L+ E LE++ +LE L+++ K Sbjct: 796 LQK-------------NLEELKISSK-RLEQLEK-ENKSLEQETSQLEKDKKQLEKENKR 840 Query: 1357 TEQNYEAEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVK-KNID---- 1411 Q E + L++ + +L ++ +++ + +Y SCV+ K ++ Sbjct: 841 LRQQAEIKDTTLEENNVKIG------NLEKENKTLSK---EIGIYKESCVRLKELEKENK 891 Query: 1412 -----GTIEFSGEFGVKEETNIVKLLEKQYQEQLEE---EVAKVIVSMS--IAFAQQTEL 1461 TI+ ++E+ KL +Q LE+ E+ K+ ++ + Q T+ Sbjct: 892 ELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDD 951 Query: 1462 SRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKEL 1521 SR + S+ + ++E+ E +L + Q K+ ++ L + Sbjct: 952 SRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQ 1011 Query: 1522 GEHGKEILLSNSDP---HDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASR 1578 E E ++ +S P D ++ T E + KD+ I E + +++ A + Sbjct: 1012 DE---ERMVQSSPPISGEDNKWERESQETTRELLKVKDRL------IEVERNNATLQAEK 1062 Query: 1579 QLMLNE-EQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQ- 1636 Q + + +QLE L Q Q+ T L++ Q + +LQ E LN Q Sbjct: 1063 QALKTQLKQLETQNNNLQAQILALQRQTVSLQE----QNTTLQTQNAKLQVENSTLNSQS 1118 Query: 1637 ----------LAQRSSIDNEN--LVSERERV---------------LLEELEALKQLSL- 1668 L Q+SS++NEN ++ ERE + LL E +A + SL Sbjct: 1119 TSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLI 1178 Query: 1669 -------AGREKLCCELRNSSTQTQNGNENQGEVE--EQTFKEKELDRKPEDVPPEILSN 1719 + + L E R+ + + +G++E E+ K ++ E+ E ++ Sbjct: 1179 SKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAA 1238 Query: 1720 ERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEAS 1778 E L N+RL +++K T V +T +++ +L+ S Q+ R EAE S Sbjct: 1239 EYKKLCGENDRLNHTYSQLLKET-EVLQTDHKNLKSLLNNSKLEQT------RLEAEFS 1290 Score = 78.6 bits (192), Expect = 1e-13 Identities = 169/742 (22%), Positives = 317/742 (42%), Gaps = 101/742 (13%) Query: 2993 MQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTALGTTDAVGL 3052 +Q Q++ E + Q + D + + +Q+V + +V + E+T + D L Sbjct: 133 VQCQKKEEFIERIQGLDF--DTKAAVAAHIQEVTHNQENVFDLQWM-EVTDMSQEDIEPL 189 Query: 3053 LNC----LEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEK 3108 L L++ I E+ + +E ++ D L + AQ +KR + + Sbjct: 190 LKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASS-SAQSPCGSPGMKRTESRQH 248 Query: 3109 PSQEL---------LEYNIQQKQSQMLEMQVELSSMKDRATELQEQ-------------- 3145 S EL L +++K Q+L+ + EL M+ LQ++ Sbjct: 249 LSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMY 308 Query: 3146 ------LSSEKMVVAELKSELAQTKLELETT--LKAQHKHLKELEAFRLEVKDKTDEVHL 3197 L + + V +L+SE+++ K L KA+ + LKE LE K + Sbjct: 309 RDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKT------M 362 Query: 3198 LNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQL---NLL 3254 L D L + +S +L LEKE +L K +L D++ + +++ +L N+ Sbjct: 363 LEDQLEGTRARSDKLH-ELEKENLQL-------KAKLHDMEMERDMDRKKIEELMEENMT 414 Query: 3255 LEQ-QKQLLNES-QQKIESQRMLYDAQLSEEQGRNL--ELQVLLESEKVRIREMSSTLDR 3310 LE QKQ ++ES E +++ ++LSE ++L E+ L S +++ + +L + Sbjct: 415 LEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTK 474 Query: 3311 E-RELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQT- 3368 EL + S +G + E+ + L K++E + IV+ EK L + Q Sbjct: 475 TVEELRTTVDSVEGNASKILKMEKEN--QRLSKKVEILENEIVQ-----EKQSLQNCQNL 527 Query: 3369 RQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRL 3428 + + K++ KT++T +E N+E Q K+ L+ + E L + + RQ+ Sbjct: 528 SKDLMKEKAQLEKTIETLRE-NSERQIKI--LEQENEHLNQTVSSLRQR----------- 573 Query: 3429 QGIMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYA 3488 I E + +++E+E K IL++++ E T+ L+ +++++E ++ A Sbjct: 574 SQISAEARVKDIEKENK-----ILHESIKE-TSSKLSKIEFEKRQIKKELEHYKEKGERA 627 Query: 3489 KLIEMNGGGTGCNHELEMIRQK---LQCVASKLQVLPQKASERLQFETADDEDFIWVQEN 3545 + E+ E E++++K L+ K++ L Q+ SE L+ E + + +N Sbjct: 628 E--ELENELHHLEKENELLQKKITNLKITCEKIEALEQENSE-LERENRKLKKTLDSFKN 684 Query: 3546 IDEIILQLQKLTGQQGEEPSLVS---PSTSCGSL-TERLLRQNAELTGHISQLTEEKNDL 3601 + + L+K Q EE + S C S+ +L +N EL QL + L Sbjct: 685 LTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELL 744 Query: 3602 RNMVMKLEEQIRWYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRA 3661 + K E Y+ + N I+ + SE + E TLQK+L+ Sbjct: 745 KASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQ-LESELQDLEMENQTLQKNLEEL 803 Query: 3662 EAEVYKL-KAELRNDSLLQTLS 3682 + +L + E N SL Q S Sbjct: 804 KISSKRLEQLEKENKSLEQETS 825 >gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] Length = 1411 Score = 162 bits (409), Expect = 8e-39 Identities = 259/1287 (20%), Positives = 555/1287 (43%), Gaps = 201/1287 (15%) Query: 147 EQGAQDSPTHLEMMESELAGKQHEIEELNRELEEMRVTYGTEGLQQ----LQEFEAAIKQ 202 EQ A T + ++S+ ++ E RE E +VT TE L + +Q+ + + Q Sbjct: 162 EQKAAQLATEIADIKSK-----YDEERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQ 216 Query: 203 RDGI--ITQLTANLQQARREKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTA 260 R GI + L L Q + D LE +S+KL+ + ++LQ+ +T S Sbjct: 217 RPGIEDVAVLKKELVQVQTLMDNMT---LERERESEKLKDECKKLQSQYASSEATISQLR 273 Query: 261 ADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSN 320 ++L + Q++ + Q+L++ + + +K + T + L+++ ++E+ E+ + Sbjct: 274 SELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENL--LKKEQDYTKLEEKHNEESVS 331 Query: 321 KEEIQ----EKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNM 376 K+ IQ +K+ ++L +++ E + +L+ + +L+E++ + + +++ Sbjct: 332 KKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHL 391 Query: 377 KLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAE 436 K E +Q+ + + QL + +L + + + + R++++ Q E+L + Sbjct: 392 KAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDK 451 Query: 437 LDEMYGQQIV------QMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKL 490 ++ Q+ Q+K+++ Q + KT+ + + + AL+ + + E Q L Sbjct: 452 EQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDL 511 Query: 491 MNVA--INELNIKLQDTNSQKEKLKEELGLILEEK------------------------C 524 V I + + K+Q+ + +K KE + L+ +E+ Sbjct: 512 EQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNH 571 Query: 525 ALQRQLEDLVEELSFSREQIQRARQTIAEQ------------------ESKLNEAHKSLS 566 LQ Q+ L E+L E ++A++ + +Q E+ +NE + L+ Sbjct: 572 TLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLN 631 Query: 567 TVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEM-LEKEKNAVLDRMAESQEAELERL 625 ++ +++ +++ EL L EA T + L+ L+ +NA+ D+ + EL ++ Sbjct: 632 ESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDK-----QQELNKI 686 Query: 626 RTQL------LFSHEEELSKLKEDLEI--EHRINIEKLKDNL-GIHYKQQIDGLQNEMSQ 676 TQL L +E S+L+ L+ E +++E+ + L G K + D L+ + S+ Sbjct: 687 TTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASK 746 Query: 677 KIETMQFEKDNLITKQNQL-ILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEE 735 + ++ + +L E+SK ++++ +V+S ++ + L+ + L ++E Sbjct: 747 EQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQE 806 Query: 736 KEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHT 795 +EK L+Q+ + L +T++ +++ + + +++ E L E T++D L + Sbjct: 807 EEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKL---S 863 Query: 796 PVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEK 855 VS DS+K+ S +EKE + DL++ C +L +++ Q Sbjct: 864 KVS--------DSLKNSK--SEFEKENQKGKAAILDLEKTCKELKHQLQVQ--------- 904 Query: 856 NFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSS 915 E +E +E +K LE K + K +L ++ E+L +Q N T+K Sbjct: 905 -MENTLKEQKE-------LKKSLEKEKEASH-QLKLELNSMQEQL-IQAQN--TLKQNEK 952 Query: 916 VFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISF 975 + + + E + E +K L +L++ +K EL + L +QL Q E++ Sbjct: 953 EEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENK---LQQQLTQAAQELAA 1009 Query: 976 LNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSV 1035 E++ L+ E+ ++L+ +E + + L V S E + Sbjct: 1010 EKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQD-----LKSVEEKLSLAQEDLI 1064 Query: 1036 SKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQL--ILDHLPSVTKESSLRATQPSEND 1093 S N+ G ++K++ E K + + K++QL L + KE SL+ Sbjct: 1065 SNRNQ-IGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLK-------- 1115 Query: 1094 KLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFA 1153 +KEL KS+ ++ E ++ ++K + L EEL Sbjct: 1116 --EKELVNEKSKLAEI-----------------------EEIKCRQEKEITKLNEELKSH 1150 Query: 1154 QEEKIKELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEY 1213 + E IKE+ + + Q + Q+ +GK L+ AV +E + Sbjct: 1151 KLESIKEITNLKDAK-QLLIQQKLELQGK-----ADSLKAAVEQE-------------KR 1191 Query: 1214 YTPALKCEVNAEDKENSGDYISENE--DPELQDYRYEVQDFQENMHTLLNKVTEEYNKLL 1271 LK +V E++E ++I + E+++ ++ +EN L ++T L Sbjct: 1192 NQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENL- 1250 Query: 1272 VLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDL 1331 + K W + + + + E + + ++ LE N++ + +L L Sbjct: 1251 ---GTVKKEW---------QSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRAL--L 1296 Query: 1332 EK-TKLEEQVQELESLISSLQQQLKET 1357 E+ K E ++++L++ + LQ++L T Sbjct: 1297 ERCLKGEGEIEKLQTKVLELQRKLDNT 1323 Score = 154 bits (388), Expect = 2e-36 Identities = 253/1160 (21%), Positives = 477/1160 (41%), Gaps = 178/1160 (15%) Query: 1856 KLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAV 1915 K EA+ + + H + L R+ ++ + L+ L EE E+L Sbjct: 58 KHYEAVHDAGNDSGHGGESNLALKRDDVTLLRQEVQDLQAS------LKEEKWYSEELKK 111 Query: 1916 ELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEEREL 1975 EL K +G+ ++Q + ++ EL +L+E + E I++ ++L Sbjct: 112 ELEKYQGL-----------QQQEAKPDGLVTDSSAELQSLEQQLEEAQTENFNIKQMKDL 160 Query: 1976 LSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVS 2035 ++ + E ++ + + E+ ++E E + ++ ++L K+ + Sbjct: 161 FEQKAAQLATEIADIKSKY--DEERSLREAAEQK--VTRLTEELNKEATVI--------- 207 Query: 2036 RFIELEQEKNTELMDLR--QQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQ 2093 Q+ TEL+ + L+K+L +++ +D ++RE E + + E +KL+ Q Sbjct: 208 ------QDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQ 261 Query: 2094 --------------LKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDI 2139 L P+ + + ++++ N L +K +E LL KEQ + Sbjct: 262 YASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKL 321 Query: 2140 QERNEE-----------IEKLEFRVRELEQALLVEDRK-HFGAVEAKPELSLEVQLQAER 2187 +E++ E + + + ++L+ L + H VE + +L+ E Sbjct: 322 EEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEEL 381 Query: 2188 DAIDRKEKEITNLEEQLEQFREELENKN----EEVQQLHMQL--------------EIQK 2229 ++ K + + +QL+Q REE E E+ QLH +L + Q+ Sbjct: 382 SEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQR 441 Query: 2230 KESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEV----E 2285 + S+ +L + EQ+ + + +L +KE ST+ QH L K Q QE++ Sbjct: 442 QLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQL-DKTKQQHQEQQALQQST 500 Query: 2286 IDQLNEQVTKLQQQL--------KITTDNKVIEEKNELIRDLETQIECLMS------DQE 2331 +L E L+Q L KI ++++ E I LE + E L + + Sbjct: 501 TAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGET 560 Query: 2332 CVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALE 2391 V +E+ L E + +L ++L N + +L ++ K L L+LE Sbjct: 561 AVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLE 620 Query: 2392 QQVETANEEMTFMKNVLKETNFKMNQLTQELFSLK----RERESVEKIQSIPENSVNVAI 2447 V N ++ K + + + ++ T+ L S + +R ++ +N++ Sbjct: 621 TSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQ 680 Query: 2448 DHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTV---SAKD 2504 L+K +L+ V T E+ + +S + K ++LE + +LE + A Sbjct: 681 QELNKITTQLDQV-TAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADS 739 Query: 2505 LELTQCYKQ-IKDMQEQGQFETEM------------LQKKIVNLQKIVEEKVAAALVSQI 2551 LE+ +Q ++D+Q+Q Q T++ ++K+IV+ ++ +K + AL S Sbjct: 740 LEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIK 799 Query: 2552 QLEAVQEYAK--FCQDNQTISSEP--ERTNIQNLNQLREDELGS---DISALTLRISELE 2604 Q QE K QD +T+S E + + N Q EL + AL +S ++ Sbjct: 800 QKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVK 859 Query: 2605 SQVVEMHTSLILEKEQVEIAEKN----VLEKEKKLLELQKLL----------EGNEKKQR 2650 ++ ++ SL K + E + +L+ EK EL+ L + KK Sbjct: 860 DKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSL 919 Query: 2651 EKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELAS--YKEKAEKLQ 2708 EKEK+ S Q L + E + + NE E + + + + +S K++ E LQ Sbjct: 920 EKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQ 979 Query: 2709 EELLVKETNMT----SLQKDLSQVRDHLAEAKEKLSIL----EKEDETEVQ--------E 2752 EL + T LQ+ L+Q LA KEK+S+L EK ET Q E Sbjct: 980 GELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRE 1039 Query: 2753 SKKACMFEPLPIKLSKSIASQTD---GTLKISSSNQTPQILVKNAGIQINLQSECSSEEV 2809 S+ + L K +Q D +I + N+ Q L K A + Q E+ Sbjct: 1040 SELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQEL-KTAKATLE-QDSAKKEQQ 1097 Query: 2810 TEIISQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQC 2869 + + + I+K + L E+++ +S+ ++E E +K + L EE Sbjct: 1098 LQERCKALQDIQKEKSLKEKELVNEKSK-LAEIEEIKCRQEKEITKLNEE---------- 1146 Query: 2870 LRSKEGSSIPELAH-SDAYQ 2888 L+S + SI E+ + DA Q Sbjct: 1147 LKSHKLESIKEITNLKDAKQ 1166 Score = 145 bits (365), Expect = 1e-33 Identities = 290/1377 (21%), Positives = 571/1377 (41%), Gaps = 224/1377 (16%) Query: 1135 MENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKA 1194 + E SLKEE +++E K KEL+K L+ Q E KP L+ Sbjct: 88 LRQEVQDLQASLKEEKWYSEELK-KELEKYQGLQQQ---------EAKPDGLVT------ 131 Query: 1195 VSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQE 1254 + S LQ+L L E T + + E ++ E +++ E + +E Sbjct: 132 ---DSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLA-TEIADIKSKYDEERSLRE 187 Query: 1255 NMHTLLNKVTEEYNK-LLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTN 1313 + ++TEE NK V+Q +++ + G E++ + E + + + M N Sbjct: 188 AAEQKVTRLTEELNKEATVIQDLKTELLQRP--------GIEDVAVLKKELVQVQTLMDN 239 Query: 1314 LEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQ 1373 + + + + L+D E KL+ Q E+ IS L+ +L + Q + LQK Sbjct: 240 MT---LERERESEKLKD-ECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKS 295 Query: 1374 AVSESTVPPSLPVDSVVITESD---AQRTMYPGSCVKKNIDGTI--------EFSGEFGV 1422 +V+E T ++++ E D + S KKNI T+ + Sbjct: 296 SVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSA 355 Query: 1423 KEETNI----VKLLEK-QYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKEN-----TA 1472 E T++ V+L EK + ++L+EE+++V A+ +L + KE + Sbjct: 356 SE-TSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQS 414 Query: 1473 SSKQAHAVCQQEQHYFNEM--------KLSQDQIGFQTFETVDVKFK-----EEFKP--- 1516 Q H+ + + E +LS +++ + + D++ K E+ K Sbjct: 415 EINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVT 474 Query: 1517 --------LSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSI--H 1566 L K +H ++ L S + E+++ + + ++ KD+ +++ Sbjct: 475 NSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQK 534 Query: 1567 DEISVSSMDASRQLMLNEEQLEDMRQELVRQYQE-----HQQATELLRQAHMRQMERQRE 1621 + ++S ++ R+ + + Q + ++ Q QE +Q T+L + Q E ++ Sbjct: 535 SKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLK-NQSESHKQ 593 Query: 1622 DQEQLQEEIKRLNRQL--AQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELR 1679 QE L ++++ L AQ + E V+E L E E + QL + + K L Sbjct: 594 AQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLS 653 Query: 1680 NSSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVV 1739 + +T + Q L + ALQ L KI ++ Sbjct: 654 AEAAKTAQRADLQNH----------------------LDTAQNALQDKQQELNKITTQLD 691 Query: 1740 KTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHE---EHTRVTDESIP 1796 + TA +++ + SQ + L E S++ E + ++ +S+ Sbjct: 692 QVTAKLQDK----------QEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLE 741 Query: 1797 SYSGSDMPRNDINMWSKVTEE----GTELSQRLV--RSGFAGTEIDPENE-ELMLNISSR 1849 + + D+ ++ + TELS++L + + T +D + + E + +I + Sbjct: 742 VKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQK 801 Query: 1850 L--QAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEES 1907 L Q +++L+ ET SQ +T++ E + + T + EL++ E+ Sbjct: 802 LTKQEEEKQILKQDFETLSQ-------ETKIQHEELNNRIQTTVT-----ELQKVKMEKE 849 Query: 1908 RAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQ-ELEAEQ 1966 +L+ K V D + K+ FE++ Q+ I LE+ ++LQ ++E Sbjct: 850 ALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTL 909 Query: 1967 QQIQEERELLSRQKEA---MKAEAGPVEQQLLQETEKLMK-EKLEVQCQA-----EKVRD 2017 ++ +E ++ L ++KEA +K E +++QL+Q L + EK E Q Q ++ + Sbjct: 910 KEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSE 969 Query: 2018 DLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQA-------LEKQLEKMR---K 2067 +KQ++AL+ +++ V + ELE + +L Q+ A L+ EK + K Sbjct: 970 QKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFK 1029 Query: 2068 FLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSE 2127 L RE E +Q+++ +E++L + + +Q +L LK + Sbjct: 1030 QLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQ 1089 Query: 2128 LLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVEDRKHFGAVEAKPELSLEVQLQAER 2187 KEQ +QER + ++ ++ + + L++ LV ++ +E E++ Sbjct: 1090 DSAKKEQ---QLQERCKALQDIQ-KEKSLKEKELVNEKSKLAEIE-------EIKC---- 1134 Query: 2188 DAIDRKEKEITNLEEQLEQFR----EELENKNEEVQQLHMQ-LEIQKKESTTR--LQELE 2240 R+EKEIT L E+L+ + +E+ N + Q L Q LE+Q K + + +++ + Sbjct: 1135 ----RQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEK 1190 Query: 2241 QENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQL 2300 + ++ KD ++K +K+ H I+EKEV + + E KL Q+ Sbjct: 1191 RNQQILKDQVKKEEEELKKEFIEKEAKLH-------SEIKEKEVGMKKHEENEAKLTMQI 1243 Query: 2301 KITTDN-----KVIEEKNELIRDLETQIECLMSD----QECVKRNREE------------ 2339 +N K + + +LE Q + L + + V+ N++E Sbjct: 1244 TALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGE 1303 Query: 2340 -EIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVE 2395 EIE+L + +LQ++L N T+ L E SL+ + + K A + +V+ Sbjct: 1304 GEIEKLQTKVLELQRKLDN----TTAAVQELGRENQSLQIKHTQALNRKWAEDNEVQ 1356 Score = 145 bits (365), Expect = 1e-33 Identities = 237/1166 (20%), Positives = 492/1166 (42%), Gaps = 155/1166 (13%) Query: 321 KEEIQEKETIIEELNTKIIEEEKKTLELKDKL-----------TTADKLLGELQEQIVQK 369 ++E+Q+ + ++E EE KK LE L T + L L++Q+ + Sbjct: 89 RQEVQDLQASLKE-EKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQLEEA 147 Query: 370 NQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRK 429 E N+K +QK Q + EI + +E + Q T + + + +E Sbjct: 148 QTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEA-TV 206 Query: 430 LEQLRAELDEMYG-QQIVQMKQELIRQHMAQMEEMKTRHKGEME---------------- 472 ++ L+ EL + G + + +K+EL+ Q M+ M + E E Sbjct: 207 IQDLKTELLQRPGIEDVAVLKKELV-QVQTLMDNMTLERERESEKLKDECKKLQSQYASS 265 Query: 473 ----NALRSY-----SNITVNEDQIKLMNVAINELN-----------------IKLQDTN 506 + LRS + V +++ + ++NEL KL++ + Sbjct: 266 EATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKH 325 Query: 507 SQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLS 566 +++ K+ + L +K + L LS S + R ++E+ + + LS Sbjct: 326 NEESVSKKNIQATLHQK---DLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELS 382 Query: 567 TVE----DLKAEIVSASESRKELE---LKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQE 619 VE LKAE + R+E E L+ ++E+ KL E++ R+ E ++ Sbjct: 383 EVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQ 442 Query: 620 AELERL--RTQLLFSHEEELSKLKEDL--------EIEHRINIEKLKDNLGIHYKQQIDG 669 E+L + Q + + +LS+L+E L E++H+++ K + H +QQ Sbjct: 443 LSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQ-----HQEQQ--A 495 Query: 670 LQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQ------SLVNSKSEEMTLQINE 723 LQ + K+ Q + + ++ + +I L+ L Q SL+ + E++ +I Sbjct: 496 LQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQA 555 Query: 724 LQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDE 783 + E +L Q +++ TL+++V +L K + + K+ + +L ++ + +A +D Sbjct: 556 GEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDR 615 Query: 784 KKTLEDML-KIHTPVSQEERLIFLDSIKSKSKDSV------------------WEKEIEI 824 +LE + ++++ +++ + + I+ K+K + + Sbjct: 616 VLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNA 675 Query: 825 LIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNK 884 L ++ ++L + QL++ K ++ + E + +E +E+Y L + ++LE K Sbjct: 676 LQDKQQELNKITTQLDQVTAKLQDKQEHCSQ-LESHLKEYKEKYLSLEQKTEELEGQIKK 734 Query: 885 QE---LEYKSKLKALNEELHLQRINPTTVKMK----SSVFDEDKTFVAETLEMGEVVEKD 937 E LE K+ + ++L QR T ++++ S + +K V+ T + + Sbjct: 735 LEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEA 794 Query: 938 TTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGE----ISFLNEEVKSLKQEKE----- 988 + +KL + EK L Q LS++ K +H E I E++ +K EKE Sbjct: 795 LESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTE 854 Query: 989 --QVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVN--KSFGE 1044 V + ++ + ++++E + +++LD T + V N K E Sbjct: 855 LSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKE 914 Query: 1045 ESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKS 1104 K + ++K + + + S QEQLI +++L+ + E +LQ +N LK Sbjct: 915 LKKSLEKEKEASHQLKLELNSMQEQLI-------QAQNTLKQNE-KEEQQLQGNINELKQ 966 Query: 1105 EQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKI 1164 + Q+EA + L + + +EN+ + L +EL A++EKI LQ Sbjct: 967 SSEQKKKQIEALQGELKIAVLQKTE-----LENKLQQQLTQAAQELA-AEKEKISVLQNN 1020 Query: 1165 HQLELQTMKTQETGDEGKPLHLLIGKLQ-KAVSEECSYFLQTLCSVLGEYYTPALKCEVN 1223 ++ +T K ++ G+ LL + K+V E+ S + L S + K Sbjct: 1021 YEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQN-KLIQE 1079 Query: 1224 AEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQ 1283 + + + + S ++ +LQ+ +QD Q+ ++ E +KL ++ + Q Sbjct: 1080 LKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCR---Q 1136 Query: 1284 QTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQ---V 1340 + + KL E L + E + + + + + + + K +L D K +E++ Sbjct: 1137 EKEITKL---NEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQ 1193 Query: 1341 QELESLISSLQQQLKETEQNYEAEIH 1366 Q L+ + +++LK+ EA++H Sbjct: 1194 QILKDQVKKEEEELKKEFIEKEAKLH 1219 Score = 139 bits (351), Expect = 4e-32 Identities = 277/1403 (19%), Positives = 610/1403 (43%), Gaps = 217/1403 (15%) Query: 479 SNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEEL--------------GLILEEKC 524 SN+ + D + L+ + +L L++ E+LK+EL GL+ + Sbjct: 76 SNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSA 135 Query: 525 ALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASE---S 581 LQ LE +EE I++ + ++ ++L + + D + + A+E + Sbjct: 136 ELQ-SLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVT 194 Query: 582 RKELELKHEAEVTNYKIKLEMLEK---EKNAVLDRMAESQEAELERLRTQLLFSHEEELS 638 R EL EA V +K E+L++ E AVL + + +++ L + E E Sbjct: 195 RLTEELNKEATVIQ-DLKTELLQRPGIEDVAVL----KKELVQVQTLMDNMTLERERESE 249 Query: 639 KLKEDLE------IEHRINIEKLKDNLG---------IHYKQQIDGLQNEMSQKIETMQF 683 KLK++ + I +L+ L + Q++ NE++QK +T+ Sbjct: 250 KLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTL-- 307 Query: 684 EKDNLITKQNQLILEISKLKDL-QQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLE 742 +NL+ K+ + +KL++ + V+ K+ + TL +L + ++ + + +L Sbjct: 308 -TENLLKKEQ----DYTKLEEKHNEESVSKKNIQATLHQKDLDCQ-QLQSRLSASETSLH 361 Query: 743 QEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLE--------DMLKIH 794 + EL K E +K +KE+ ++++ K+ L+AE L+ +++ E ++ ++H Sbjct: 362 RIHVELSEKGEATQK-LKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLH 420 Query: 795 TPVSQEERLI-----FLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNT 849 + + + ER + L + S + + +KE ++ DL+ + +L E+++++ Sbjct: 421 SKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQV-----ADLQLKLSRLEEQLKEKVTN 475 Query: 850 FSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTT 909 + + + Q+ QE+ A L +++N E + + +++ +Q + Sbjct: 476 STELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLR---QIGDKDQKIQNLEALL 532 Query: 910 VKMKS--SVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLK 967 K K S+ ++++ + ++ GE +L EK + + +L+++L + SE K Sbjct: 533 QKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHK 592 Query: 968 QKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMT 1027 Q L+++V ++++ LR + + V S +T V+ L Sbjct: 593 QAQEN---LHDQV-----QEQKAHLRAAQ----------DRVLSLETSVNEL-------- 626 Query: 1028 SRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRAT 1087 S++N+S + S++ ++ K E + E +K Q ++ L Sbjct: 627 -------NSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQ-------RADLQNHLDTA 672 Query: 1088 QPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLK 1147 Q + DK Q+ELN + ++ + + +++ ++ H Q+ +++ K+K L Sbjct: 673 QNALQDK-QQELNKITTQLDQVTAKLQDKQ--------EHCSQLESHLKEYKEKYLS--L 721 Query: 1148 EELIFAQEEKIKELQKIHQLELQTMKTQETGD------EGKPLHLLIGKLQKAVSEECSY 1201 E+ E +IK+L+ LE++ K Q D L L +L K + E Sbjct: 722 EQKTEELEGQIKKLE-ADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEI 780 Query: 1202 FLQTLCSVLGEYYT-PALKCEVNAEDKEN---SGDYISENEDPELQDYRYEVQDFQENMH 1257 T + + ++K ++ +++E D+ + +++ ++Q E+ + + Sbjct: 781 VSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQ--HEELNNRIQTTV 838 Query: 1258 TLLNKVTEEYNKLL----VLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTN 1313 T L KV E L+ ++ +LSK+ K EF +EN K + L + Sbjct: 839 TELQKVKMEKEALMTELSTVKDKLSKV-SDSLKNSKSEFEKEN-QKGKAAILDLEKTCKE 896 Query: 1314 LE-DIDVNHKSKLSSLQDLEKT--KLEEQVQELESLISSLQQQL---KETEQNYEAEIHC 1367 L+ + V ++ L ++L+K+ K +E +L+ ++S+Q+QL + T + E E Sbjct: 897 LKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQ 956 Query: 1368 LQKRLQAVSESTVPPSLPVDSV--VITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEE 1425 LQ + + +S+ ++++ + + Q+T ++ E + E KE+ Sbjct: 957 LQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAE---KEK 1013 Query: 1426 TNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQ 1485 ++++ ++ QE ++ + S A + +L + E S Q + + Q Sbjct: 1014 ISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSV----EEKLSLAQEDLISNRNQ 1069 Query: 1486 HYFNEMKLSQD-QIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDC 1544 N+ KL Q+ + T E K +++ + K L + KE L ++ K Sbjct: 1070 -IGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEK---ELVNEKSK 1125 Query: 1545 VLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQA 1604 + I E ++K +++E+ +++ +++ L+D +Q L++Q E Q Sbjct: 1126 LAEIEEIKCRQEKEI---TKLNEELKSHKLESIKEI----TNLKDAKQLLIQQKLELQGK 1178 Query: 1605 TELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALK 1664 + L+ A +E+++ +Q+ L++++K+ +L + E+E L E++ K Sbjct: 1179 ADSLKAA----VEQEKRNQQILKDQVKKEEEELKKE--------FIEKEAKLHSEIKE-K 1225 Query: 1665 QLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQ----TFKEKELDRKPEDVPPEIL--- 1717 ++ + E+ +L T NEN G V+++ + EL+++ +D+ EI Sbjct: 1226 EVGMKKHEENEAKLTMQITAL---NENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLE 1282 Query: 1718 ------SNERYAL-----------QKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRS 1760 +ER AL +K ++L++ ++ TTAAV+E LG ++S Sbjct: 1283 ATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQE------LGRENQS 1336 Query: 1761 SKSQSSASLIWRSEAEASVKSCV 1783 + + + +L + + V++C+ Sbjct: 1337 LQIKHTQALNRKWAEDNEVQNCM 1359 Score = 139 bits (350), Expect = 5e-32 Identities = 258/1338 (19%), Positives = 559/1338 (41%), Gaps = 183/1338 (13%) Query: 2201 EEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKES 2260 E L R+++ +EVQ L L+ +K S +ELE+ L + + + GL S Sbjct: 75 ESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSS 134 Query: 2261 DAMSTQDQHV---------------LFGKFAQIIQEKEVEIDQLNEQVTKLQQ--QLKIT 2303 + + +Q + LF + A + + +I ++ L++ + K+T Sbjct: 135 AELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVT 194 Query: 2304 TDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTS 2363 + + ++ +I+DL+T E ++R E++ L + + ++Q + N+ + Sbjct: 195 RLTEELNKEATVIQDLKT---------ELLQRPGIEDVAVLKKELVQVQTLMDNMTLERE 245 Query: 2364 MNAHSLSEEADSLKHQ-------LDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMN 2416 + L +E L+ Q + + +E Q+V +E+ +K+ + E K Sbjct: 246 RESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQ 305 Query: 2417 QLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFK 2476 LT+ L LK+E++ + + E SV+ + + +L+ + L + E + Sbjct: 306 TLTENL--LKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRI 363 Query: 2477 SFEENGKGSII-NLETRLLQLESTVSAKDLELTQCYKQIKDMQEQG---QFETEMLQKKI 2532 E + KG L+ L ++E+ E Q +Q ++ ++ G Q E L K+ Sbjct: 364 HVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKL 423 Query: 2533 VNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSD 2592 + ++ + E L Q QL + + + E + ++Q E++L Sbjct: 424 LETERQLGE-AHGRLKEQRQLSS----------EKLMDKEQQVADLQLKLSRLEEQLKEK 472 Query: 2593 ISALTLRISEL--------ESQVVEMHTSLILEKEQVEIAE--KNVLEKEKKLLELQKLL 2642 ++ T +L E Q ++ T+ L + Q ++ + + + +K++K+ L+ LL Sbjct: 473 VTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALL 532 Query: 2643 EGNEKKQREKEKKR---------SPQDVEVLKTTTELFHSNEESGFFNELEALRAESVAT 2693 + +++ EK+R + VL E H+ +E E L+ +S + Sbjct: 533 QKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQ-VTQLTEKLKNQSESH 591 Query: 2694 KAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQES 2753 K + ++ ++ + L + + SL+ ++++ L E+KEK+S L+ + + + + Sbjct: 592 KQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTE-- 649 Query: 2754 KKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTEII 2813 L + A++T + + T Q +++ ++N ++T + Sbjct: 650 -----------LLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELN--------KITTQL 690 Query: 2814 SQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLR-- 2871 Q T K++ QE H S+ E+ +E+ L+++ L+ I+ L Sbjct: 691 DQVTAKLQDKQE------------HCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEAD 738 Query: 2872 SKEGSSIPELAHSDAYQTR------EICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESE 2925 S E + E A D Q R E+ +++ + S D+ + ES Sbjct: 739 SLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESI 798 Query: 2926 SATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINTISS 2985 + ++ K +L+ Q + ++ ++ ++ + + E++A + +S+ Sbjct: 799 KQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKM-EKEALMTELST 857 Query: 2986 LKDLITKMQLQREAEVYDSSQSHESFSDWRGE-LLLALQQVFLEERSVLLAAFRTELTAL 3044 +KD ++K+ ++ +S+S + +G+ +L L++ E + L + E T Sbjct: 858 VKDKLSKV-----SDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQL--QVQMENTLK 910 Query: 3045 GTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQ 3104 + L ++ + +E + E L +A ++ L + + Q+ G LK+ Sbjct: 911 EQKELKKSLEKEKEASHQLKLELNSMQEQLIQA--QNTLKQNEKEEQQLQGNINELKQSS 968 Query: 3105 ESEKPSQELLEYNIQ-----------QKQSQMLEMQVELSSMKDRATELQEQLSSEKMVV 3153 E +K E L+ ++ + Q Q+ + EL++ K++ + LQ + Sbjct: 969 EQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETF 1028 Query: 3154 AEL-------KSELAQTKLELETT-----------------LKAQHKHLKELEAFRLEVK 3189 +L +SEL T+ +L++ + Q+K ++EL+ + ++ Sbjct: 1029 KQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLE 1088 Query: 3190 D----KTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEE---RDKEELEDLKFSLE 3242 K ++ L QK+ + L EK+KL EE R ++E+ L L+ Sbjct: 1089 QDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELK 1148 Query: 3243 SQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIR 3302 S K +++ L+ KQLL QQK+E Q + + EQ + + Q+L + K Sbjct: 1149 SHKLESIKEITNLKDAKQLL--IQQKLELQGKADSLKAAVEQEKRNQ-QILKDQVKKEEE 1205 Query: 3303 EMSST-LDRERELHAQLQSSDGTGQSRPPLPSEDL----------LKELQKQLEEKHSRI 3351 E+ +++E +LH++++ + G + L L ++K+ + R+ Sbjct: 1206 ELKKEFIEKEAKLHSEIKEKE-VGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRV 1264 Query: 3352 VELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQL 3411 EL +T+ + + ++ ++ R L E +G+ ++ +LQ+KV +LQR+L Sbjct: 1265 SELEKQTDDLRGEIAVLEATVQNNQDERRALL----ERCLKGEGEIEKLQTKVLELQRKL 1320 Query: 3412 EEKRQQVYKLDLEGQRLQ 3429 + V +L E Q LQ Sbjct: 1321 DNTTAAVQELGRENQSLQ 1338 Score = 116 bits (290), Expect = 5e-25 Identities = 269/1358 (19%), Positives = 571/1358 (42%), Gaps = 197/1358 (14%) Query: 864 LQEEYACLLKVKDDLEDSKNKQELEYK---------SKLKALNEELHLQRINPTTVKMKS 914 L+EE ++K +LE + Q+ E K ++L++L ++L + +K Sbjct: 99 LKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQLEEAQTENFNIKQMK 158 Query: 915 SVFDEDKTFVA-----------ETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLS 963 +F++ +A E + E E+ T L E+L + + + DL Sbjct: 159 DLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELN-------KEATVIQDLK 211 Query: 964 EQLKQKHG--EISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLD 1021 +L Q+ G +++ L +E+ ++ + ++L RE E + + +QS Q +S Sbjct: 212 TELLQRPGIEDVAVLKKELVQVQTLMDNMTLE-RERESEKLKDECKKLQS---QYASSEA 267 Query: 1022 GVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKE 1081 + + S A+G +E + V++ ++ +V E +++ Q + ++L + KE Sbjct: 268 TISQLRSELAKGP---------QEVAVYVQELQKLKS-SVNELTQKNQTLTENL--LKKE 315 Query: 1082 SSLRATQPSENDKLQKELNVLKS-EQNDLRLQMEAQRICLS--LVYSTHVDQVREYMENE 1138 + N++ + N+ + Q DL Q R+ S ++ HV+ +E Sbjct: 316 QDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVEL------SE 369 Query: 1139 KDKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEE 1198 K +A LKEEL + K L+ + + Q+ +E K H L +LQ +++ Sbjct: 370 KGEATQKLKEELSEVET-------KYQHLKAEFKQLQQQREE-KEQHGL--QLQSEINQL 419 Query: 1199 CSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHT 1258 S L+T LGE + LK E ++ S + +L D +V D Q + Sbjct: 420 HSKLLETERQ-LGEAHG-RLK-----EQRQLSSE--------KLMDKEQQVADLQLKLSR 464 Query: 1259 LLNKVTEEYNKLLVLQTRLSKIWGQ--------QTDGMKLEFGEENLPKEETEFLSIHSQ 1310 L ++ E+ LQ +L K Q Q+ KL + +L + + + Sbjct: 465 LEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQK 524 Query: 1311 MTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQK 1370 + NLE + K +S L+ E+ L ++Q E + L Q L+E + ++ L + Sbjct: 525 IQNLEALLQKSKENISLLEK-EREDLYAKIQAGEGETAVLNQ-LQEKNHTLQEQVTQLTE 582 Query: 1371 RLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFG-VKEETNIV 1429 +L+ SES + V + R D + + + N Sbjct: 583 KLKNQSESHKQAQENLHDQVQEQKAHLRAAQ---------DRVLSLETSVNELNSQLNES 633 Query: 1430 KLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFN 1489 K Q Q++ + ++ + + AQ+ +L +N KQ Q Sbjct: 634 KEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQV 693 Query: 1490 EMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTIS 1549 KL Q E+ ++KE++ L ++ E +I +D ++ SK+ L Sbjct: 694 TAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDL 753 Query: 1550 EEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLR 1609 ++ ++ ++ ++ + + + S+QL + +E + R +L Q+ +A E ++ Sbjct: 754 QQ----------QRQLNTDLELRATELSKQLEMEKEIVSSTRLDL----QKKSEALESIK 799 Query: 1610 QAHMRQMERQ---REDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQL 1666 Q +Q E + ++D E L +E K + +L R + V+E ++V +E+ + +L Sbjct: 800 QKLTKQEEEKQILKQDFETLSQETKIQHEELNNRI----QTTVTELQKVKMEKEALMTEL 855 Query: 1667 SLAGREKLCCELRNSSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQK 1726 S ++KL + + + ++++ E E Q K LD L+K Sbjct: 856 STV-KDKL-----SKVSDSLKNSKSEFEKENQKGKAAILD-----------------LEK 892 Query: 1727 ANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEE 1786 L L ++ T ++ L +S + + AS + E + + + + Sbjct: 893 TCKELKHQLQVQMENTLKEQKE--------LKKSLEKEKEASHQLKLELNSMQEQLIQAQ 944 Query: 1787 HTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQ-RLVRSGFAGTEIDPENEELMLN 1845 +T +E ++ N++ S+ ++ E Q L + TE++ + ++ + Sbjct: 945 NTLKQNEKEEQQLQGNI--NELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQ 1002 Query: 1846 ISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQE---ATESLKCQEELRER 1902 + L A EK IS + E ++ T +L + + ++ E + LK EE Sbjct: 1003 AAQELAAEKEK----ISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSL 1058 Query: 1903 LHEESRA-------REQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRL------- 1948 E+ + + +L EL A+ ++ + +K E+Q+QE+ + + Sbjct: 1059 AQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKK---EQQLQERCKALQDIQKEKSLK 1115 Query: 1949 EQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEV 2008 E+EL+ ++L E+E + + ++E L+ + ++ K E+ L + L+++KLE+ Sbjct: 1116 EKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLEL 1175 Query: 2009 QCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKF 2068 Q +A+ ++ ++++ + +I +++QV + E+E+ + + +EK+ + + Sbjct: 1176 QGKADSLKAAVEQEKRNQQI-LKDQVKK----EEEE--------LKKEFIEKEAKLHSEI 1222 Query: 2069 LDEQAIDREHERD--VFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCS 2126 +++ ++HE + +I L + L V + S+ + E+E+ + L+ + Sbjct: 1223 KEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLE 1282 Query: 2127 ELLLSKEQLQRDIQER----NEEIEKLEFRVRELEQAL 2160 + + + +R + ER EIEKL+ +V EL++ L Sbjct: 1283 ATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKL 1320 Score = 108 bits (270), Expect = 1e-22 Identities = 244/1245 (19%), Positives = 512/1245 (41%), Gaps = 184/1245 (14%) Query: 2497 ESTVSAKDLELTQCYKQIKDMQ---EQGQFETEMLQKKIVNLQKIVEEKVAA-ALVSQIQ 2552 ES ++ K ++T ++++D+Q ++ ++ +E L+K++ Q + +++ LV+ Sbjct: 75 ESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSS 134 Query: 2553 LEAVQEYAKFCQDNQTISSEPERTNIQNLNQLRED---ELGSDISALTLRISE------- 2602 E +Q + ++ QT E NI+ + L E +L ++I+ + + E Sbjct: 135 AE-LQSLEQQLEEAQT-----ENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREA 188 Query: 2603 LESQVVEMHTSLILEKEQVEIAEKNVLEK---------EKKLLELQKLLEGNEKKQREKE 2653 E +V + L E ++ + +L++ +K+L+++Q L++ N +RE+E Sbjct: 189 AEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMD-NMTLERERE 247 Query: 2654 KKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELL- 2712 ++ + + L++ + S+E + + LR+E E+A Y ++ +KL+ + Sbjct: 248 SEKLKDECKKLQSQ---YASSEAT-----ISQLRSELAKGPQEVAVYVQELQKLKSSVNE 299 Query: 2713 VKETNMTSLQKDLSQVRDH--LAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLSKSI 2770 + + N T + L + +D+ L E + S+ +K + + + C + L +LS S Sbjct: 300 LTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDC--QQLQSRLSASE 357 Query: 2771 ASQTDGTLKISSSNQTPQIL-------------VKNAGIQINLQSECSSE-------EVT 2810 S +++S + Q L +K Q+ Q E + E+ Sbjct: 358 TSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEIN 417 Query: 2811 EIISQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCL 2870 ++ S+ E ++ E H E R +S + + +E VA LK L + + L Sbjct: 418 QLHSKLLETERQLGEAHGRL---KEQRQLSSEKLMDKEQQVADLQLK-----LSRLEEQL 469 Query: 2871 RSKEGSSIPELAHSDAYQTREICSSDSGSDWGQGIYLTHSQGF---DIASEGRGEESESA 2927 + K +S EL H +T++ L +Q + G ++ Sbjct: 470 KEKVTNST-ELQHQ-LDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQN 527 Query: 2928 TDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEP--WLEERKAYINTISS 2985 ++ +K K + + E + + ++ +GE + Q+ E L+E+ Sbjct: 528 LEALLQKSKENISLLEKEREDLYAKIQA--GEGETAVLNQLQEKNHTLQEQ--------- 576 Query: 2986 LKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTALG 3045 + L K++ Q E+ H+ + + L A +V E SV EL + Sbjct: 577 VTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSV------NELNSQ- 629 Query: 3046 TTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQE 3105 LN ++++ + ++ +A E L A+ + + ++QE Sbjct: 630 -------LNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQE 682 Query: 3106 SEKPSQEL--LEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQT 3163 K + +L + +Q KQ +++ L K++ L+++ + + +L+++ + Sbjct: 683 LNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEV 742 Query: 3164 KLELETTLK--AQHKHLK---ELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEK 3218 K E L+ Q + L EL A L K E +++ T QKKS ALE Sbjct: 743 KASKEQALQDLQQQRQLNTDLELRATELS-KQLEMEKEIVSSTRLDLQKKSE----ALES 797 Query: 3219 EKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDA 3278 K KL + E EE + LK E+ Q + + E+ + + +++ +M +A Sbjct: 798 IKQKLTKQE----EEKQILKQDFETLSQ---ETKIQHEELNNRIQTTVTELQKVKMEKEA 850 Query: 3279 QLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLK 3338 ++E L + K ++ ++S +L + ++ + + G++ L E K Sbjct: 851 LMTE-----------LSTVKDKLSKVSDSLKNSK---SEFEKENQKGKA-AILDLEKTCK 895 Query: 3339 ELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMH 3398 EL+ QL+ + ++ E +K + Q++ + ++ L Q + +K+ Sbjct: 896 ELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQ 955 Query: 3399 ELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELEREEKRESRRILYQNLNE 3458 +LQ + +L++ E+K++Q+ + LQG ++ Q+ E E K L Q L + Sbjct: 956 QLQGNINELKQSSEQKKKQI-------EALQGELKIAVLQKTELENK------LQQQLTQ 1002 Query: 3459 PTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMIRQKLQCVASKL 3518 L +++ + VLQ E + ++ G EL RQ L+ V KL Sbjct: 1003 -AAQELAAEKEKISVLQNNY-----EKSQETFKQLQSDFYGRESELLATRQDLKSVEEKL 1056 Query: 3519 QVLPQ-------------KASERLQFETAD-DEDFIWVQENIDEIILQLQKLTGQQG-EE 3563 + + K + L+ A ++D ++ + E LQ + ++ +E Sbjct: 1057 SLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKE 1116 Query: 3564 PSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKLEEQIRWYRQTGAGRD 3623 LV+ + + E RQ E+T +L K + + L++ + Q Sbjct: 1117 KELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQ------ 1170 Query: 3624 NSSRFSLNGGA-NIEAIIASEKEVWNREKLTLQKSLKRAEAEVYK 3667 + L G A +++A + EK R + L+ +K+ E E+ K Sbjct: 1171 --QKLELQGKADSLKAAVEQEK----RNQQILKDQVKKEEEELKK 1209 Score = 96.3 bits (238), Expect = 5e-19 Identities = 166/762 (21%), Positives = 316/762 (41%), Gaps = 117/762 (15%) Query: 2967 QVSEPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVF 3026 Q E LEE + I +KDL + Q E+ D ++ Sbjct: 138 QSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYD----------------- 180 Query: 3027 LEERSVLLAAFR--TELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLS 3084 EERS+ AA + T LT +A + + + +Q G+E A + + L Sbjct: 181 -EERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVL--------KKELV 231 Query: 3085 EIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQE 3144 ++Q L M TL+RE+ESEK E ++ QSQ + +S ++ + + Sbjct: 232 QVQTLMDNM-----TLERERESEKLKDEC-----KKLQSQYASSEATISQLRSELAKGPQ 281 Query: 3145 QLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLN--DTL 3202 +++ + +LKS + + + +T + K KE + +LE K + V N TL Sbjct: 282 EVAVYVQELQKLKSSVNELTQKNQTLTENLLK--KEQDYTKLEEKHNEESVSKKNIQATL 339 Query: 3203 ASEQKKSRELQWALEKEKAKL----------GRSEERDKEELEDLKFSLESQKQRNLQLN 3252 + ++LQ L + L G + ++ KEEL +++ + K QL Sbjct: 340 HQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQ 399 Query: 3253 LLLEQQKQ---LLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLD 3309 E+++Q L ++ S+ + + QL E GR L+ Q L SEK+ +D Sbjct: 400 QQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGR-LKEQRQLSSEKL--------MD 450 Query: 3310 RERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTR 3369 +E+++ A LQ L L++QL+EK + EL ++ +K T+ Sbjct: 451 KEQQV-ADLQLK---------------LSRLEEQLKEKVTNSTELQHQLDK-------TK 487 Query: 3370 QQMEKDRQVHRKTLQTEQEANTEGQKKMHEL---QSKVEDLQRQLEEKRQQVYKLDLEGQ 3426 QQ ++ + + + T +EA + ++ + ++ K+++L+ L++ ++ + L+ E + Sbjct: 488 QQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKERE 547 Query: 3427 RLQGIMQEFQKQELEREEKRESRRILYQNL--------NEPTTWSLTSDRTRNWVLQQKI 3478 L +Q + + + +E L + + N+ + + + V +QK Sbjct: 548 DLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKA 607 Query: 3479 EGETKESNYAKL-IEMNGGGTGCNHELEMIRQ-KLQCVASKLQVLPQKASERLQFETADD 3536 + L +N + N E + Q +Q A +L +A++ Q AD Sbjct: 608 HLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQ--RADL 665 Query: 3537 EDFIWVQEN-IDEIILQLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQLT 3595 ++ + +N + + +L K+T Q + + + S E L++ E + Q T Sbjct: 666 QNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKT 725 Query: 3596 EEKNDLRNMVMKLEEQIRWYRQTG--AGRDNSSRFSLNGGANIEAIIAS-----EKEVWN 3648 EE L + KLE + + A +D + LN + A S EKE+ + Sbjct: 726 EE---LEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVS 782 Query: 3649 REKLTLQKSLKRAEAEVYKLKAELRNDSLL----QTLSPDSE 3686 +L LQK + E+ KL + +L +TLS +++ Sbjct: 783 STRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETK 824 Score = 80.5 bits (197), Expect = 3e-14 Identities = 138/640 (21%), Positives = 269/640 (42%), Gaps = 49/640 (7%) Query: 3063 QGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQ 3122 QG++ Q A D + L ++ + +K+ ++ + L I + Sbjct: 117 QGLQQQEAKPDGLVTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIK 176 Query: 3123 SQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTK-LELETTLKAQHKHLKEL 3181 S+ E + + + + T L E+L+ E V+ +LK+EL Q +E LK + ++ L Sbjct: 177 SKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTL 236 Query: 3182 -EAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFS 3240 + LE + +++++ L S+ S L E AK + +EL+ LK S Sbjct: 237 MDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSS 296 Query: 3241 LE--SQKQRNLQLNLLLEQQKQLLNESQQKIES-QRMLYDAQLSEEQGRNLELQVLLESE 3297 + +QK + L NLL ++Q E + ES + A L ++ +LQ L + Sbjct: 297 VNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSAS 356 Query: 3298 KVRIREMSSTLDRERELHAQLQSSDGTGQSR-PPLPSEDLLKELQKQLEEKHSRIVELLN 3356 + + + L + E +L+ +++ L +E K+LQ+Q EEK ++L + Sbjct: 357 ETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAE--FKQLQQQREEKEQHGLQLQS 414 Query: 3357 ETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEK-- 3414 E + L+T +Q+ + ++ Q E + ++++ +LQ K+ L+ QL+EK Sbjct: 415 EINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVT 474 Query: 3415 -----RQQVYKLDLEGQRLQGIMQE--FQKQELEREEKRESRRILYQNLNEPTTWSLTSD 3467 + Q+ K + Q Q + Q + +E + + ++ R+I ++ +L Sbjct: 475 NSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQK 534 Query: 3468 RTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMIRQKLQCVASKL--QVLPQKA 3525 N L +K +E YAK I+ G T ++L+ LQ ++L ++ Q Sbjct: 535 SKENISLLEK----EREDLYAK-IQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSE 589 Query: 3526 SERLQFETADDE------DFIWVQENIDEIILQLQKLTGQQGEEPSLVSP-STSCGSLTE 3578 S + E D+ Q+ + + + +L Q E VS + TE Sbjct: 590 SHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTE 649 Query: 3579 RLL-------RQNAELTGHISQLTEEKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRFSLN 3631 LL Q A+L H+ D + + K+ Q+ + T +D S Sbjct: 650 LLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLD--QVTAKLQDKQEHCS-- 705 Query: 3632 GGANIEAIIASEKEVWNREKLTLQKSLKRAEAEVYKLKAE 3671 +E+ + KE + L+L++ + E ++ KL+A+ Sbjct: 706 ---QLESHLKEYKEKY----LSLEQKTEELEGQIKKLEAD 738 Score = 39.3 bits (90), Expect = 0.077 Identities = 59/314 (18%), Positives = 129/314 (41%), Gaps = 19/314 (6%) Query: 3400 LQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELEREEKRESRRILYQNLNEP 3459 L+ +V+DLQ L+E++ +L E ++ QG+ Q+ K + + + L Q L E Sbjct: 88 LRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQLEEA 147 Query: 3460 TTWSLTSDRTRNWVLQQKIEGETKESNY-AKLIEMNGGGTGCNHELEMIRQKLQCVASKL 3518 T + + ++ Q+ + T+ ++ +K E ++ + ++L A+ + Sbjct: 148 QTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVI 207 Query: 3519 QVLPQKASERLQFETAD--DEDFIWVQENIDEIILQLQKLTGQQGEE-----PSLVSPST 3571 Q L + +R E ++ + VQ +D + L+ ++ + + +E S Sbjct: 208 QDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEA 267 Query: 3572 SCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMK---LEEQIRWYRQTGAGRDNSSRF 3628 + L L + E+ ++ +L + K+ + + K L E + Q + Sbjct: 268 TISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNE 327 Query: 3629 SLNGGANIEAIIASEKEVWNREKLTLQKSLKRAEAEVYKLKAEL-RNDSLLQTLSPDSEH 3687 NI+A + + + + LQ L +E ++++ EL Q L + Sbjct: 328 ESVSKKNIQATLHQK----DLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSE 383 Query: 3688 VTLKRIYGKYLRAE 3701 V K ++L+AE Sbjct: 384 VETKY---QHLKAE 394 Score = 33.5 bits (75), Expect = 4.2 Identities = 28/133 (21%), Positives = 59/133 (44%), Gaps = 11/133 (8%) Query: 123 FVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPT-----HLEMMESELAGKQHEIEELNRE 177 F+ + K + ++E+E G+ + +L ++ E Q + EL ++ Sbjct: 1211 FIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQ 1270 Query: 178 LEEMR--VTYGTEGLQQLQEFEAAIKQR----DGIITQLTANLQQARREKDETMREFLEL 231 +++R + +Q Q+ A+ +R +G I +L + + +R+ D T EL Sbjct: 1271 TDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQEL 1330 Query: 232 TEQSQKLQIQFQQ 244 ++Q LQI+ Q Sbjct: 1331 GRENQSLQIKHTQ 1343 >gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] Length = 1976 Score = 159 bits (403), Expect = 4e-38 Identities = 231/1158 (19%), Positives = 491/1158 (42%), Gaps = 164/1158 (14%) Query: 158 EMMESELAGKQHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQA 217 E M + LA K+ E+EE+ +LE RV E Q LQ + ++ A++Q Sbjct: 907 EEMRARLAAKKQELEEILHDLES-RVEEEEERNQILQNEK----------KKMQAHIQDL 955 Query: 218 RREKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQL 277 + DE +L + + + ++++ L +S + + +I QL Sbjct: 956 EEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQL 1015 Query: 278 EEQDHLLEDYQKKKEDFTMQISFLQEKIKV-----YEMEQDKKVENSN----KEEIQEKE 328 E++ ++ K + + IS L+E++K E+E+ K+ + +++I E + Sbjct: 1016 AEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQ 1075 Query: 329 TIIEELNTKIIEEEKKTLELKDKLTTAD----------KLLGELQEQIVQKNQEIKNMKL 378 I+EL ++ ++E+ EL+ L D K++ ELQ QI + ++ ++ K Sbjct: 1076 AQIDELKLQLAKKEE---ELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKA 1132 Query: 379 ELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELD 438 +++++R SEE++ L +E+ +T Q QE + K EQ AEL Sbjct: 1133 SRNKAEKQKRDLSEELEALKTELED---------TLDTTAAQ---QELRTKREQEVAELK 1180 Query: 439 EMYGQQIVQMKQELIRQHMAQMEEMKTRH-------KGEMENALRSYSNITVNEDQIKLM 491 + +E + H AQ+++M+ RH ++E A R +N+ N+ ++ Sbjct: 1181 KAL--------EEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETD 1232 Query: 492 NVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTI 551 N + LQ ++ E +++L ++E A + + L EL+ ++Q + Sbjct: 1233 NKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNV 1292 Query: 552 AEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVL 611 + + L EA K A + S + +EL + + N ++ LE+EKN++ Sbjct: 1293 S---TLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQ 1349 Query: 612 DRMAESQEA--ELER----LRTQL-------------LFSHEEELSKLKEDLE-IEHRI- 650 ++ E +EA LE+ L++QL + S EE KL +D E + R+ Sbjct: 1350 EQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLE 1409 Query: 651 -------NIEKLKDNLGIHYKQQIDGL------QNEMSQKIETMQFEKDNLITKQNQLIL 697 +EK K+ L +Q++D L Q +++ +E Q + D L+ ++ + Sbjct: 1410 EKALAYDKLEKTKNRL----QQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISA 1465 Query: 698 EISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEK 757 ++ +D ++ K + L++ +E + E++ L ++++L + + K Sbjct: 1466 RYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGK 1525 Query: 758 QMKEKEND---LQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSK 814 + E E L+++ ++ + L+DE + ED K+ V+ + + Sbjct: 1526 NVHELEKSKRALEQQVEEMRTQLEELEDELQATED-AKLRLEVNMQ------------AM 1572 Query: 815 DSVWEKEIEILIEENEDLKQQCIQLNEEIE-------KQRNTFSFAEKNFEVNYQELQEE 867 + +E++++ E+NE+ K+ I+ E+E KQR ++K E++ ++L+ + Sbjct: 1573 KAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQ 1632 Query: 868 YACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAET 927 K +D++ KQ + ++++K EL R + + +F + K E+ Sbjct: 1633 IEAANKARDEV----IKQLRKLQAQMKDYQRELEEARAS------RDEIFAQSK----ES 1678 Query: 928 LEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLK--- 984 + + +E + +L E+L ++R + Q +L++++ S L +E + L+ Sbjct: 1679 EKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARI 1738 Query: 985 -QEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFG 1043 Q +E++ +E++ + R +Q + S A + + NK Sbjct: 1739 AQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNK--- 1795 Query: 1044 EESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLK 1103 E K + + +SK + I + + + E K + + Sbjct: 1796 -------ELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTE 1848 Query: 1104 SEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQK 1163 + ++ +Q+E +R H DQ +E ME + + + LK +L A+EE + Sbjct: 1849 KKLKEIFMQVEDER--------RHADQYKEQME-KANARMKQLKRQLEEAEEEATRANAS 1899 Query: 1164 IHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVN 1223 +L+ + E +EG L + L+ + + S + + E++ Sbjct: 1900 RRKLQRELDDATE-ANEG--LSREVSTLKNRLRRGGPISFSSSRSGRRQLHLEGASLELS 1956 Query: 1224 AEDKENSGDYISENEDPE 1241 +D E+ ++E + P+ Sbjct: 1957 DDDTESKTSDVNETQPPQ 1974 Score = 151 bits (381), Expect = 1e-35 Identities = 262/1208 (21%), Positives = 513/1208 (42%), Gaps = 178/1208 (14%) Query: 225 MREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLL 284 ++ L++T Q ++LQ + ++L + + + ++ HQQ LEE++ L Sbjct: 841 VKPLLQVTRQEEELQAKDEELLKVKEKQTKVEG-------ELEEMERKHQQLLEEKNILA 893 Query: 285 EDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKK 344 E Q + E F E E+ + + K+E++E I+ +L +++ EEE++ Sbjct: 894 EQLQAETELFA-------------EAEEMRARLAAKKQELEE---ILHDLESRVEEEEER 937 Query: 345 TLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEEL 404 L+++ + +L+EQ+ ++ + ++LE ++ K ++ EEI L E+ Sbjct: 938 NQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLL----EDQ 993 Query: 405 QKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMK 464 + K+ + ME QL E ++ ++ KQE++ + + + + Sbjct: 994 NSKFIKEKKL-------MEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKE 1046 Query: 465 TRHKGEMENALRSYSNITVN-EDQIKLMNVAINELNIKLQDTNSQKEKLKEELGL----I 519 + + E+E A R T + +DQI + I+EL ++L ++E+L+ L Sbjct: 1047 EKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLA---KKEEELQGALARGDDET 1103 Query: 520 LEEKCALQ--RQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVS 577 L + AL+ R+L+ + EL E + +R +Q+ L+E ++L T + + + Sbjct: 1104 LHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELE---DTLD 1160 Query: 578 ASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEEL 637 + +++EL K E EV K LE K A + M + LE L QL E+ Sbjct: 1161 TTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQL-----EQA 1215 Query: 638 SKLKEDLEIEHRINIEKLKDNLGIHYK--QQIDGLQNEMSQKIETMQFEKDNLITKQNQL 695 + K +LE +++ +E L K QQ+ +K++ E +++ ++L Sbjct: 1216 KRFKANLE-KNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRL 1274 Query: 696 ILEIS-KLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTEL 754 +E++ K LQ L N TL +K I+ K+ +LE ++Q+ Q EL Sbjct: 1275 RVELAEKASKLQNELDNVS----TLLEEAEKKGIKF----AKDAASLESQLQDTQ---EL 1323 Query: 755 LEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSK 814 L+++ ++K N L + QLE E + L+++++ E+ K + E++++ L S + +K Sbjct: 1324 LQEETRQKLN-LSSRIRQLEEEKNSLQEQQEEEEEARK-----NLEKQVLALQSQLADTK 1377 Query: 815 DSVWEK--EIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLL 872 V + IE L E + L + L++ +E++ + Sbjct: 1378 KKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAY---------------------- 1415 Query: 873 KVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFD----EDKTFVAETL 928 D LE +KN+ + E L L +L QR + ++ K FD E+K+ A Sbjct: 1416 ---DKLEKTKNRLQQE----LDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYA 1468 Query: 929 EMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKE 988 E E+D E + + TK L L++ L + E ++ + L +++ L K+ Sbjct: 1469 E-----ERDRAEAEAREKETK--ALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKD 1521 Query: 989 QVSLRCRELEIIINHNRA--ENVQSCDTQVSSLLDGV-----------VTMTSRGAEGSV 1035 V ELE RA + V+ TQ+ L D + V M + A+ Sbjct: 1522 DVGKNVHELE---KSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFER 1578 Query: 1036 S-KVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILD-----HLPSVTKESSLRATQP 1089 + EE K ++ +V + +E KQ L + + E+ + A Sbjct: 1579 DLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANK 1638 Query: 1090 SENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEE 1149 + D++ K+L L+++ D + ++E R +++ E +K L SL+ E Sbjct: 1639 A-RDEVIKQLRKLQAQMKDYQRELEEARASRDEIFA---------QSKESEKKLKSLEAE 1688 Query: 1150 LIFAQEE--KIKELQKIHQLELQTMKTQETG---------DEGKPLHLLIGKLQKAVSEE 1198 ++ QEE + ++ + E + + T DE + L I +L++ + EE Sbjct: 1689 ILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEE 1748 Query: 1199 CS-------YFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYEVQD 1251 S F +T V + L E +A K ++ E ++ EL+ E++ Sbjct: 1749 QSNMELLNDRFRKTTLQV--DTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEG 1806 Query: 1252 FQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQM 1311 ++ E K+ L+ +L + ++ KL E KE F+ + + Sbjct: 1807 AVKSKFKATISALEA--KIGQLEEQLEQEAKERAAANKLVRRTEKKLKE--IFMQVEDER 1862 Query: 1312 TNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISS---LQQQL---KETEQNYEAEI 1365 + + + + ++ L K +LEE +E +S LQ++L E + E+ Sbjct: 1863 RHADQYKEQMEKANARMKQL-KRQLEEAEEEATRANASRRKLQRELDDATEANEGLSREV 1921 Query: 1366 HCLQKRLQ 1373 L+ RL+ Sbjct: 1922 STLKNRLR 1929 Score = 149 bits (377), Expect = 4e-35 Identities = 228/1126 (20%), Positives = 478/1126 (42%), Gaps = 184/1126 (16%) Query: 1550 EEMFSKDKTFIVRQSI-------HDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQ 1602 EEM K + + ++I E+ + + +L +++LE++ +L + +E + Sbjct: 876 EEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEE 935 Query: 1603 QATELLR------QAHMRQMERQREDQEQLQEEIK--------RLNRQLAQRSSIDNENL 1648 + ++L+ QAH++ +E Q +++E +++++ ++ + + ++++N Sbjct: 936 ERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNS 995 Query: 1649 VSERERVLLEELEALKQLSLAGRE---KLCCELRNSSTQTQNGNENQGEVEEQTFKEKEL 1705 +E+ L+E+ A LA E K ++RN + E + + EE+T +E E Sbjct: 996 KFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEK 1055 Query: 1706 DRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQS 1765 ++ D L ++ LQ ++ ++ L++ K ++ + R D + ++ Sbjct: 1056 AKRKLDGETTDLQDQIAELQA---QIDELKLQLAKKEEELQGALARG-----DDETLHKN 1107 Query: 1766 SASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKV--TEEGTELSQ 1823 +A + R E +A + + + + D+ + +++ T + T Q Sbjct: 1108 NALKVVR-ELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQ 1166 Query: 1824 RL-VRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAK---------- 1872 L + E+ EE N +++Q ++ A+ E S QLE AK Sbjct: 1167 ELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNK 1226 Query: 1873 ----------VTQTELMRESFRQKQEATESLKCQ-EELRERLHEESRAREQLAVELSKAE 1921 + +++++ + + + L Q +EL ++ E R R +LA + SK + Sbjct: 1227 QGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQ 1286 Query: 1922 GVIDG--------------YADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQ 1967 +D +A + E Q+Q+ +++ ++ L S+R+++LE E+ Sbjct: 1287 NELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKN 1346 Query: 1968 QIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALE 2027 +QE++E ++ ++ + ++ Q L +T+K + + L E+ + L K +AL Sbjct: 1347 SLQEQQEEEEEARKNLEKQVLALQSQ-LADTKKKVDDDLGTIESLEEAKKKLLKDAEALS 1405 Query: 2028 IDVEEQVSRFIELEQEKN---TELMDL-------RQQNQALEKQLEKMRKFL-DEQAIDR 2076 +EE+ + +LE+ KN EL DL RQ LEK+ +K + L +E++I Sbjct: 1406 QRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISA 1465 Query: 2077 EHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQ 2136 + + + E + E++ K + + + E E+ K+ +L+ SK+ + Sbjct: 1466 RYAEERDRAEAEAREKETKALSLARAL-EEALEAKEEFERQNKQLRADMEDLMSSKDDVG 1524 Query: 2137 RDIQERNEEIEKLEFRVRELEQALLVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKE 2196 +++ E + LE +V E+ L LE +LQA DA R E Sbjct: 1525 KNVHELEKSKRALEQQVEEMRTQL----------------EELEDELQATEDAKLRLE-- 1566 Query: 2197 ITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLA 2256 N++ QF +L+ ++E+ ++ L Q +E L++ ++ L +K+ + Sbjct: 1567 -VNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEID 1625 Query: 2257 IKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELI 2316 +K+ +A I+ D++ +Q+ KLQ Q+K + Sbjct: 1626 LKDLEAQ---------------IEAANKARDEVIKQLRKLQAQMK------------DYQ 1658 Query: 2317 RDLETQIECLMSDQECVKRNREEE--IEQLNEVIEKLQQELANIGQKTSMNAHSLSEEAD 2374 R+LE E S E +++E E ++ L I +LQ+ELA+ + E AD Sbjct: 1659 RELE---EARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELAD 1715 Query: 2375 SL-------------KHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQE 2421 + K +L+ IA+ LE+++E M + + ++T +++ L E Sbjct: 1716 EITNSASGKSALLDEKRRLEARIAQ---LEEELEEEQSNMELLNDRFRKTTLQVDTLNAE 1772 Query: 2422 LFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVL--TEDALKSLENQTYFKSFE 2479 L + ER + +K + A L + EL+ L E A+KS FK+ Sbjct: 1773 LAA---ERSAAQKSDN--------ARQQLERQNKELKAKLQELEGAVKS-----KFKATI 1816 Query: 2480 ENGKGSIINLETRLLQ-------LESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKI 2532 + I LE +L Q V + +L + + Q++D + E ++K Sbjct: 1817 SALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKAN 1876 Query: 2533 VNLQKI------VEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSE 2572 ++++ EE+ A S+ +L+ +E + N+ +S E Sbjct: 1877 ARMKQLKRQLEEAEEEATRANASRRKLQ--RELDDATEANEGLSRE 1920 Score = 133 bits (334), Expect = 4e-30 Identities = 290/1335 (21%), Positives = 556/1335 (41%), Gaps = 256/1335 (19%) Query: 2033 QVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQ 2092 QV+R E Q K+ EL+ ++++ +E +LE+M +R+H+ Q LE+ Sbjct: 846 QVTRQEEELQAKDEELLKVKEKQTKVEGELEEM---------ERKHQ--------QLLEE 888 Query: 2093 QLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNE----EIEK 2148 + + + Q +E E E++ L K + E+L E + +ERN+ E +K Sbjct: 889 KNILAEQLQAETE-LFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKK 947 Query: 2149 LEFRVRELEQALLVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFR 2208 ++ +++LE+ L E+ A+ +L LE ++ AE I + E+EI LE+Q +F Sbjct: 948 MQAHIQDLEEQLDEEEG-------ARQKLQLE-KVTAEAK-IKKMEEEILLLEDQNSKFI 998 Query: 2209 EELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQ 2268 +E + + + + QL +++E L ++ + ++ D+E+ +++ + + Sbjct: 999 KEKKLMEDRIAECSSQLA-EEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAK 1057 Query: 2269 HVLFGKFAQI---IQEKEVEIDQLNEQVTKLQQQLK---ITTDNKVIEEKNEL--IRDLE 2320 L G+ + I E + +ID+L Q+ K +++L+ D++ + + N L +R+L+ Sbjct: 1058 RKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQ 1117 Query: 2321 TQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQL 2380 QI L D E K +R + +Q + LSEE ++LK +L Sbjct: 1118 AQIAELQEDFESEKASRNKAEKQKRD----------------------LSEELEALKTEL 1155 Query: 2381 DVVIAEKLALEQQVETANE-EMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIP 2439 + + + A +Q++ T E E+ +K L+E Q++ +R ++E++ Sbjct: 1156 EDTL-DTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDM--RQRHATALEELSEQL 1212 Query: 2440 ENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLEST 2499 E + + L K+K LE E A + Q E K L+ ++ +L + Sbjct: 1213 EQAKRFKAN-LEKNKQGLETDNKELACEVKVLQQVKAESEHKRK----KLDAQVQELHAK 1267 Query: 2500 VSAKD---LELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAV 2556 VS D +EL + + LQ ++ N+ ++EE A Sbjct: 1268 VSEGDRLRVELAE--------------KASKLQNELDNVSTLLEE-------------AE 1300 Query: 2557 QEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLIL 2616 ++ KF +D ++ S+ +Q+ +L ++E ++ L+ RI +LE E SL Sbjct: 1301 KKGIKFAKDAASLESQ-----LQDTQELLQEETRQKLN-LSSRIRQLE----EEKNSLQE 1350 Query: 2617 EKEQVEIAEKNVLEKEKKLLELQKLLEGNEKK---------QREKEKKRSPQDVEVLKTT 2667 ++E+ E A KN+ EK++L LQ L +KK E+ KK+ +D E L Sbjct: 1351 QQEEEEEARKNL---EKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQR 1407 Query: 2668 TELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQ 2727 E E++ +++LE + +LQ+EL DL+ Sbjct: 1408 LE-----EKALAYDKLEKTK-----------------NRLQQEL-----------DDLTV 1434 Query: 2728 VRDHLAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTP 2787 DH + L +K+ + + E K +S A + D + +T Sbjct: 1435 DLDHQRQVASNLEKKQKKFDQLLAEEKS----------ISARYAEERDRAEAEAREKETK 1484 Query: 2788 QILVKNAGIQINLQSECSSEEVTEIISQFTEKIEKMQELHAAEILDMESRHISETETLKR 2847 + + A EE E +F + ++++ DME S+ + K Sbjct: 1485 ALSLARA-----------LEEALEAKEEFERQNKQLRA-------DMEDLMSSKDDVGKN 1526 Query: 2848 EHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPEL-AHSDAYQTREICSSDSGSDWGQGIY 2906 H L++ L+ ++ +R++ EL A DA E+ + + + + Sbjct: 1527 VHE-----LEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDL- 1580 Query: 2907 LTHSQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQ 2966 + R E++E K+++ L + +E Q S + Sbjct: 1581 -----------QTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVAS----------K 1619 Query: 2967 QVSEPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVF 3026 + E L++ +A I + +D + K + +A++ D + E R E+ + Sbjct: 1620 KKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSK--- 1676 Query: 3027 LEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRS-LLSE 3085 E L + E+ L L + R + + A E A +S LL E Sbjct: 1677 --ESEKKLKSLEAEILQLQEE----LASSERARRHAEQERDELADEITNSASGKSALLDE 1730 Query: 3086 IQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQ 3145 + L A++ L+ E E E+ + ELL ++ Q+ + EL++ + A + Sbjct: 1731 KRRLEARI----AQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNA 1786 Query: 3146 LSSEKMVVAELKSELAQTKLELETTLKAQHKH-LKELEAFRLEVKDKTDEVHLLNDTLAS 3204 + ELK++L ELE +K++ K + LEA +++++ ++ A Sbjct: 1787 RQQLERQNKELKAKLQ----ELEGAVKSKFKATISALEAKIGQLEEQLEQE-------AK 1835 Query: 3205 EQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQ---L 3261 E+ + +L EK+ ++ E ++ + K +E R QL LE+ ++ Sbjct: 1836 ERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATR 1895 Query: 3262 LNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIR-----EMSSTLDRERELH- 3315 N S++K+ QR L DA + E G + E+ L K R+R SS+ R+LH Sbjct: 1896 ANASRRKL--QRELDDATEANE-GLSREVSTL----KNRLRRGGPISFSSSRSGRRQLHL 1948 Query: 3316 --AQLQSSDGTGQSR 3328 A L+ SD +S+ Sbjct: 1949 EGASLELSDDDTESK 1963 Score = 132 bits (333), Expect = 5e-30 Identities = 275/1362 (20%), Positives = 573/1362 (42%), Gaps = 246/1362 (18%) Query: 1878 LMRESFRQKQEATESLK-----CQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKT 1932 L R++F +KQ+ +LK C L+ R + R +K + ++ + T Sbjct: 801 LARKAFAKKQQQLSALKVLQRNCAAYLKLRHWQWWRV-------FTKVKPLL-----QVT 848 Query: 1933 LFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQ 1992 E ++Q K + + +++++ L+E+E + QQ+ EE+ +L+ Q +A E Sbjct: 849 RQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQA--------ET 900 Query: 1993 QLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLR 2052 +L E E++ + + E++ DL+ +V E E+E+N L + + Sbjct: 901 ELFAEAEEMRARLAAKKQELEEILHDLESRV---------------EEEEERNQILQNEK 945 Query: 2053 QQNQALEKQLEKMRKFLDEQAIDREH---ERDVFQQEIQKLEQQLKVVPRFQPISEHQTR 2109 ++ QA + LE+ LDE+ R+ E+ + +I+K+E+++ ++ E Q Sbjct: 946 KKMQAHIQDLEEQ---LDEEEGARQKLQLEKVTAEAKIKKMEEEILLL-------EDQNS 995 Query: 2110 EVEQLANHLKEKTDKCSELLLSKEQLQRDIQE-RNEEIEKLEFRVRELEQALLVEDRKHF 2168 + + ++++ +CS L +E+ +++ + RN K E + +LE+ L E++ Sbjct: 996 KFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRN----KQEVMISDLEERLKKEEKTRQ 1051 Query: 2169 GAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLE-- 2226 +AK +L E + +I L+ Q+++ + +L K EE+Q + + Sbjct: 1052 ELEKAKRKLDGET---------TDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDE 1102 Query: 2227 -IQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVE 2285 + K + ++EL+ + ++D E + K S + + + L + + E E Sbjct: 1103 TLHKNNALKVVRELQAQIAELQEDFE----SEKASRNKAEKQKRDLSEELEALKTELEDT 1158 Query: 2286 IDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLN 2345 +D T QQ+L+ + +V E K L + + E + D +++ +E+L+ Sbjct: 1159 LD-----TTAAQQELRTKREQEVAELKKALEEETKNH-EAQIQD---MRQRHATALEELS 1209 Query: 2346 EVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMK 2405 E +E+ ++ AN+ N L + L ++ V+ K E + + + ++ + Sbjct: 1210 EQLEQAKRFKANL----EKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELH 1265 Query: 2406 NVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDA 2465 + E + +L ++ L+ E ++ + ++ E + I +KD LE L +D Sbjct: 1266 AKVSEGDRLRVELAEKASKLQNE---LDNVSTLLEEAEKKGI-KFAKDAASLESQL-QDT 1320 Query: 2466 LKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFET 2525 + L+ +T K +NL +R+ QLE ++ +++ QE+ + Sbjct: 1321 QELLQEETRQK----------LNLSSRIRQLEEEKNS-----------LQEQQEEEEEAR 1359 Query: 2526 EMLQKKIVNLQKIV---EEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNI---- 2578 + L+K+++ LQ + ++KV L + LE ++ K +D + +S E + Sbjct: 1360 KNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKK--KLLKDAEALSQRLEEKALAYDK 1417 Query: 2579 ----QNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEK-------EQVEIAEKN 2627 +N Q D+L D+ S LE + + L EK E+ + AE Sbjct: 1418 LEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAE 1477 Query: 2628 VLEKEKKLLELQKLLEG--NEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELE- 2684 EKE K L L + LE K++ E++ K+ D+E L ++ + N +ELE Sbjct: 1478 AREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKN-----VHELEK 1532 Query: 2685 ---ALRAESVATKAELASYKEKAEKLQEELLVKETNMTSL----QKDLSQVRDHLAEAKE 2737 AL + + +L +++ + ++ L E NM ++ ++DL Q RD E K+ Sbjct: 1533 SKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDL-QTRDEQNEEKK 1591 Query: 2738 KLSILE-KEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGI 2796 +L I + +E E E+++ +K +++A + ++I + QI Sbjct: 1592 RLLIKQVRELEAELEDERK-----------QRALAVASKKKMEIDLKDLEAQI------- 1633 Query: 2797 QINLQSECSSEEVTEIISQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLL 2856 E +++ E+I Q + K+Q A++ D + R + E + E + + Sbjct: 1634 ------EAANKARDEVIKQ----LRKLQ----AQMKDYQ-RELEEARASRDEIFAQSKES 1678 Query: 2857 KEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTR-EICSSDSGSDWGQGIYLTHSQGFDI 2915 +++ +L+A I L+ + SS E A A Q R E+ + S G+ L + + Sbjct: 1679 EKKLKSLEAEILQLQEELASS--ERARRHAEQERDELADEITNSASGKSALLDEKRRLEA 1736 Query: 2916 ASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEE 2975 EE E E+ S ++ + Sbjct: 1737 RIAQLEEELE-----------------------------------EEQSNMELLNDRFRK 1761 Query: 2976 RKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLA 3035 ++T+++ ++ +R A S + + EL LQ++ + + Sbjct: 1762 TTLQVDTLNA------ELAAERSA-AQKSDNARQQLERQNKELKAKLQEL----EGAVKS 1810 Query: 3036 AFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNG 3095 F+ ++AL + LE++++++ E AA + +++ +++ L EI Sbjct: 1811 KFKATISALEAK-----IGQLEEQLEQEAKERAAANKLVRRTEKK--LKEIFMQVEDERR 1863 Query: 3096 RKITLKREQESEKPSQELLEYNIQQKQSQMLEMQV---ELSSMKDRATELQEQLSSEKMV 3152 K + E + L+ +++ + + +L D ATE E LS E Sbjct: 1864 HADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQRELDDATEANEGLSRE--- 1920 Query: 3153 VAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDE 3194 V+ LK+ L + ++ ++ + L LE LE+ D E Sbjct: 1921 VSTLKNRLRRGGPISFSSSRSGRRQL-HLEGASLELSDDDTE 1961 Score = 130 bits (327), Expect = 3e-29 Identities = 231/1094 (21%), Positives = 464/1094 (42%), Gaps = 140/1094 (12%) Query: 698 EISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEK 757 E+ K+K+ +Q+ V + EEM + +L +E IL ++ + + L E +E++ + ++ Sbjct: 860 ELLKVKE-KQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQ 918 Query: 758 QMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLK-IHTPVSQEE---RLIFLDSIKSKS 813 +++E +DL+ + + E N IL++EKK ++ ++ + + +EE + + L+ + +++ Sbjct: 919 ELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEA 978 Query: 814 KDSVWEKEIEILIEEN----------EDLKQQC-IQLNEEIEKQRNTFSFAEKNFEVNYQ 862 K E+EI +L ++N ED +C QL EE EK +N K EV Sbjct: 979 KIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQ-EVMIS 1037 Query: 863 ELQEEYACLLKVKDDLEDSKNKQELEYK------SKLKALNEELHLQRINPTTVKMKSSV 916 +L+E K + +LE +K K + E ++L+A +EL LQ + Sbjct: 1038 DLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALA 1097 Query: 917 FDEDKTF-VAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEI-- 973 +D+T L++ ++ EL E E K + + ++ DLSE+L+ E+ Sbjct: 1098 RGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELED 1157 Query: 974 ----SFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSR 1029 + +E+++ K+E+E L+ E NH +Q + ++ L+ + + Sbjct: 1158 TLDTTAAQQELRT-KREQEVAELKKALEEETKNHE--AQIQDMRQRHATALEELSEQLEQ 1214 Query: 1030 GA--EGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQL---ILDHLPSVTKESSL 1084 + ++ K + ++K + + + + E K+++L + + V++ L Sbjct: 1215 AKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRL 1274 Query: 1085 RATQPSENDKLQKELN-----VLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEK 1139 R + KLQ EL+ + ++E+ ++ +A + L + + Q + Sbjct: 1275 RVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNL 1334 Query: 1140 DKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQ-ETGDEGKPLHLLIGKLQKAVSEE 1198 + L+EE QE++ +E + LE Q + Q + D K + +G ++ EE Sbjct: 1335 SSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESL--EE 1392 Query: 1199 CSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENED---PELQDYRYEVQDFQEN 1255 L L + E+K + D + + ++ EL D ++ D Q Sbjct: 1393 AKKKLLKDAEALSQ----------RLEEKALAYDKLEKTKNRLQQELDDLTVDL-DHQRQ 1441 Query: 1256 MHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGE------------ENLPKEETE 1303 + + L K +++++LL + +S + ++ D + E E E + + E Sbjct: 1442 VASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEE 1501 Query: 1304 FLSIHSQM-TNLEDIDVNHKSKLSSLQDLEKTK--LEEQVQELESLISSLQQQLKETEQ- 1359 F + Q+ ++ED+ + ++ +LEK+K LE+QV+E+ + + L+ +L+ TE Sbjct: 1502 FERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDA 1561 Query: 1360 ------NYEAEIHCLQKRLQAVSESTVPPS-LPVDSVVITESD-----AQRTMYPGSCVK 1407 N +A ++ LQ E L + V E++ QR + S K Sbjct: 1562 KLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKK 1621 Query: 1408 KNID-GTIEFSGEFGVKEETNIVKLLE------KQYQEQLEEEVAKVIVSMSIAFAQQTE 1460 ID +E E K ++K L K YQ +LEE A S FAQ E Sbjct: 1622 MEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARA----SRDEIFAQSKE 1677 Query: 1461 LSR--------ISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKE 1512 + I +E ASS++A +QE+ + +++ G + + Sbjct: 1678 SEKKLKSLEAEILQLQEELASSERARRHAEQERDELAD-EITNSASGKSALLDEKRRLEA 1736 Query: 1513 EFKPLSKELGEHGKEILLSNSDPHDIPESKDCV-LTISEEMFSKDKTFIVRQSI---HDE 1568 L +EL E + L N D + ++ E + K+ RQ + + E Sbjct: 1737 RIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKE 1796 Query: 1569 ISVSSMDA--------SRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMR------ 1614 + + + E ++ + ++L ++ +E A +L+R+ + Sbjct: 1797 LKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFM 1856 Query: 1615 QMERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKL 1674 Q+E +R +Q +E++++ N ++ Q + LEE E + A R KL Sbjct: 1857 QVEDERRHADQYKEQMEKANARMKQL-------------KRQLEEAEEEATRANASRRKL 1903 Query: 1675 CCELRNSSTQTQNG 1688 EL + +T+ G Sbjct: 1904 QREL-DDATEANEG 1916 Score = 119 bits (299), Expect = 5e-26 Identities = 245/1252 (19%), Positives = 530/1252 (42%), Gaps = 235/1252 (18%) Query: 728 IEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTL 787 +++ RQEE ELQ K E L K +KEK+ ++ + ++E ++ L +EK L Sbjct: 845 LQVTRQEE-----------ELQAKDEELLK-VKEKQTKVEGELEEMERKHQQLLEEKNIL 892 Query: 788 EDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQR 847 + L Q E +F ++ + +++ + ++E+E ++ + E ++ + N+ ++ ++ Sbjct: 893 AEQL-------QAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEK 945 Query: 848 NTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEY---KSKLKALNEELHLQR 904 K + + Q+L+E+ D+ E ++ K +LE ++K+K + EE+ L Sbjct: 946 -------KKMQAHIQDLEEQL-------DEEEGARQKLQLEKVTAEAKIKKMEEEILLLE 991 Query: 905 INPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTK-----REKLELSQRL 959 D++ F+ E M + + + +++L E+ E K R K E+ + Sbjct: 992 -------------DQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVM--I 1036 Query: 960 SDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSL 1019 SDL E+LK++ L + + L E + + EL+ I+ + + + + +L Sbjct: 1037 SDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGAL 1096 Query: 1020 LDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVT 1079 +RG + ++ K N K++ E + + ES Sbjct: 1097 --------ARGDDETLHKNNAL-----KVVRELQAQIAELQEDFES-------------- 1129 Query: 1080 KESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEK 1139 E + R + L +EL LK+E D AQ+ ++R E E Sbjct: 1130 -EKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQ------------ELRTKREQEV 1176 Query: 1140 DKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAV---S 1196 + +L+EE E +I+++++ H L+ + Q ++ K + K ++ + + Sbjct: 1177 AELKKALEEETK-NHEAQIQDMRQRHATALEELSEQL--EQAKRFKANLEKNKQGLETDN 1233 Query: 1197 EECSYFLQTLCSVLGEYYTPALKCEVNAED---KENSGDYISENEDPELQDYRYEVQDFQ 1253 +E + ++ L V E K + ++ K + GD + EL + ++Q+ Sbjct: 1234 KELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRV----ELAEKASKLQNEL 1289 Query: 1254 ENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTN 1313 +N+ TLL + ++ K L +L+ +E L +E + L++ S++ Sbjct: 1290 DNVSTLLEEAEKKGIKFAKDAASLES---------QLQDTQELLQEETRQKLNLSSRIRQ 1340 Query: 1314 LEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQ---- 1369 LE+ K+ L Q+ E EE + LE + +LQ QL +T++ + ++ ++ Sbjct: 1341 LEE----EKNSLQEQQEEE----EEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEE 1392 Query: 1370 ------KRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVK 1423 K +A+S+ +L D + T++ Q+ + D T++ + + Sbjct: 1393 AKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELD---------DLTVDLDHQ---R 1440 Query: 1424 EETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQ 1483 + + ++ +K++ + L EE S+S +A++ + + ++ T + A A+ + Sbjct: 1441 QVASNLEKKQKKFDQLLAEEK-----SISARYAEERDRAEAEAREKETKALSLARALEEA 1495 Query: 1484 EQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDP----HDIP 1539 ++ KEEF+ +K+L ++++ S D H++ Sbjct: 1496 ------------------------LEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELE 1531 Query: 1540 ESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQ 1599 +SK + EEM ++ + + DE+ + DA +L +N ++ M+ + R Q Sbjct: 1532 KSKRALEQQVEEMRTQ------LEELEDELQATE-DAKLRLEVN---MQAMKAQFERDLQ 1581 Query: 1600 EHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSS--IDNENLVSERERVLL 1657 + E ++ ++Q+ RE + +L++E K+ +A + ID ++L ++ E Sbjct: 1582 TRDEQNEEKKRLLIKQV---RELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANK 1638 Query: 1658 EELEALKQLSLAGREKLCCELRNSSTQTQNGNENQGEV----EEQTFKEKELDRKPEDVP 1713 E +KQL KL ++++ + + ++ E+ +E K K L+ + + Sbjct: 1639 ARDEVIKQL-----RKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQ 1693 Query: 1714 PEILSNER---YALQKANNRLLKILLEVVKTTAAVEET--IGRHVLGILDRSSKSQSSAS 1768 E+ S+ER +A Q+ + +I +A ++E + + + + + QS+ Sbjct: 1694 EELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNME 1753 Query: 1769 LIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRS 1828 L+ + +++ V + + E + SD R + +K + + + V+S Sbjct: 1754 LLNDRFRKTTLQ--VDTLNAELAAERSAAQK-SDNARQQLERQNKELKAKLQELEGAVKS 1810 Query: 1829 GFAGT-----------EIDPENEELMLNISSRLQAAVEKLLEAI-----------SETSS 1866 F T E E E +++L EK L+ I + Sbjct: 1811 KFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKE 1870 Query: 1867 QLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELS 1918 Q+E A +L R+ ++EAT + + +L+ L + + A E L+ E+S Sbjct: 1871 QMEKANARMKQLKRQLEEAEEEATRANASRRKLQRELDDATEANEGLSREVS 1922 Score = 118 bits (295), Expect = 1e-25 Identities = 230/1096 (20%), Positives = 451/1096 (41%), Gaps = 208/1096 (18%) Query: 1294 EENLPKEETEFLSIHSQMTN----LEDIDVNHKSKLSSLQDLEKTKLEEQVQ---ELESL 1346 EE L ++ E L + + T LE+++ H+ L EK L EQ+Q EL + Sbjct: 851 EEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLE-----EKNILAEQLQAETELFAE 905 Query: 1347 ISSLQQQLKETEQNYEAEIHCLQKRLQAVSEST--VPPSLPVDSVVITESDAQRTMYPGS 1404 ++ +L +Q E +H L+ R++ E + I + + Q G+ Sbjct: 906 AEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGA 965 Query: 1405 CVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEE--VAKVIVSMSIAFAQQTE-- 1460 K ++ + + E +K+ + LLE Q + ++E+ + I S A++ E Sbjct: 966 RQKLQLE---KVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKA 1022 Query: 1461 --LSRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVD----------- 1507 L++I +E S + ++E+ E++ ++ ++ +T + D Sbjct: 1023 KNLAKIRNKQEVMISDLEERL--KKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDE 1080 Query: 1508 --VKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISE----EMFSKDKTFIV 1561 ++ ++ + L L E L N+ + E + + + E E S++K Sbjct: 1081 LKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQ 1140 Query: 1562 RQSIHDEI---------SVSSMDASRQLMLNEEQ-LEDMRQELVRQYQEHQQATELLRQA 1611 ++ + +E+ ++ + A ++L EQ + ++++ L + + H+ + +RQ Sbjct: 1141 KRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQR 1200 Query: 1612 HMRQMERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGR 1671 H +E E EQ + L + Q DN+ L E ++ L+ +K S R Sbjct: 1201 HATALEELSEQLEQAKRFKANLEKN-KQGLETDNKELACE-----VKVLQQVKAESEHKR 1254 Query: 1672 EKLCCELRNSSTQTQNGNENQGEVEEQTFK-EKELDRKPEDVPPEILSNERYALQKANNR 1730 +KL +++ + G+ + E+ E+ K + ELD N L++A + Sbjct: 1255 KKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELD------------NVSTLLEEAEKK 1302 Query: 1731 LLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRV 1790 +K + + +++T + +L R + SS E + + EE R Sbjct: 1303 GIKFAKDAASLESQLQDT--QELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARK 1360 Query: 1791 TDE----SIPSYSGSDMPRNDINMWS---------KVTEEGTELSQRLVRSGFAGTEIDP 1837 E ++ S + D ++ + K+ ++ LSQRL A +++ Sbjct: 1361 NLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLE- 1419 Query: 1838 ENEELMLNISSRLQAAVEKL---LEAISETSSQLEHAKVTQTELMRESFRQKQEATESLK 1894 +RLQ ++ L L+ + +S LE + +L+ E E + S + Sbjct: 1420 -------KTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAE------EKSISAR 1466 Query: 1895 CQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQE-KTDIID------- 1946 EE R+R E+R +E A+ L++A ++ + K FERQ ++ + D+ D Sbjct: 1467 YAEE-RDRAEAEAREKETKALSLARA---LEEALEAKEEFERQNKQLRADMEDLMSSKDD 1522 Query: 1947 -------------RLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQ 1993 LEQ++ +L+ELE E Q ++ + L +AMKA+ Q Sbjct: 1523 VGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQT 1582 Query: 1994 LLQETEK----LMKEKLEVQCQAEKVRDDLQKQV---KALEIDV---EEQVSRFIELEQE 2043 ++ E+ L+K+ E++ + E R V K +EID+ E Q+ + E Sbjct: 1583 RDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDE 1642 Query: 2044 KNTELMDLRQQNQALEKQLEKMRKFLDE---QAIDREHERDVFQQEIQKLEQQLKVVPRF 2100 +L L+ Q + +++LE+ R DE Q+ + E + + EI +L+++L R Sbjct: 1643 VIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERA 1702 Query: 2101 QPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEK------------ 2148 + H +E ++LA+ + S LL K +L+ I + EE+E+ Sbjct: 1703 R---RHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRF 1759 Query: 2149 -------------------------------------LEFRVRELEQALLVEDRKHFGAV 2171 L+ +++ELE A+ + + A+ Sbjct: 1760 RKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISAL 1819 Query: 2172 EAKPELSLEVQLQAE-------RDAIDRKEKEITNLEEQLE-------QFREELENKNEE 2217 EAK LE QL+ E + R EK++ + Q+E Q++E++E N Sbjct: 1820 EAKIG-QLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANAR 1878 Query: 2218 VQQLHMQLEIQKKEST 2233 ++QL QLE ++E+T Sbjct: 1879 MKQLKRQLEEAEEEAT 1894 Score = 113 bits (283), Expect = 3e-24 Identities = 197/976 (20%), Positives = 415/976 (42%), Gaps = 168/976 (17%) Query: 2 EDEERQKKLEAGKAK---LAQFRQRKAQSDGQSPSKKQKKKRKTSSSKHDVSAHHDLNID 58 E+EE+ K L + K + + + + + ++ + +K KRK D+ + Sbjct: 1017 EEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQ--DQIAEL 1074 Query: 59 QSQCNEMYINSSQRVESTVIPESTIMR----TLHSGEITSHEQGFSVELESEISTTADDC 114 Q+Q +E+ + +++ E + + R TLH + EL+++I+ +D Sbjct: 1075 QAQIDELKLQLAKKEEEL---QGALARGDDETLHKNNALKVVR----ELQAQIAELQEDF 1127 Query: 115 SSEVNGCSFVMRTGKPTNLLREE----EFGVDDSYSEQGAQDSPTHLEMMESELAGK-QH 169 SE + + K L EE + ++D+ AQ EL K + Sbjct: 1128 ESEKASRN---KAEKQKRDLSEELEALKTELEDTLDTTAAQQ----------ELRTKREQ 1174 Query: 170 EIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFL 229 E+ EL + LEE + + Q A+++ L+ L+QA+R K + Sbjct: 1175 EVAELKKALEEETKNHEAQIQDMRQRHATALEE-------LSEQLEQAKRFKANLEKNKQ 1227 Query: 230 ELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQK 289 L +++L + + LQ + S H D Q+ ++ E D L + + Sbjct: 1228 GLETDNKELACEVKVLQ--QVKAESEHKRKKLDA-----QVQELHAKVSEGDRLRVELAE 1280 Query: 290 KKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELK 349 K ++ + ++ E + K +++ E Q ++T +EL + EE ++ L L Sbjct: 1281 KASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDT--QEL---LQEETRQKLNLS 1335 Query: 350 DKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNH 409 ++ ++ LQEQ ++ + KN++ ++ + + + +++ +GT+E L++ Sbjct: 1336 SRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKK 1395 Query: 410 KDSQFETDIVQRMEQET------QRKLEQLRAELDEM-----YGQQI---VQMKQELIRQ 455 K + + QR+E++ ++ +L+ ELD++ + +Q+ ++ KQ+ Q Sbjct: 1396 KLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQ 1455 Query: 456 HMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVA----------------INELN 499 +A+ + + R+ E + A E + K +++A +L Sbjct: 1456 LLAEEKSISARYAEERDRA-----EAEAREKETKALSLARALEEALEAKEEFERQNKQLR 1510 Query: 500 IKLQDTNSQKEKLKEELGLILEEKCALQR-------QLEDLVEELSFSRE---------- 542 ++D S K+ + + + + + K AL++ QLE+L +EL + + Sbjct: 1511 ADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQ 1570 Query: 543 ----QIQRARQTIAEQESKLNEAHKSL--STVEDLKAEIVSASESRKELEL------KHE 590 Q +R QT EQ NE K L V +L+AE+ + RK+ L K E Sbjct: 1571 AMKAQFERDLQTRDEQ----NEEKKRLLIKQVRELEAEL---EDERKQRALAVASKKKME 1623 Query: 591 AEVTNYKIKLEMLEKEKNAVLDRMAESQ------EAELERLRTQL--LFSHEEELSKLKE 642 ++ + + ++E K ++ V+ ++ + Q + ELE R +F+ +E K + Sbjct: 1624 IDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLK 1683 Query: 643 DLEIEHRINIEKLKDNLGI--HYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEIS 700 LE E I +L++ L ++ + ++E++ +I K L+ ++ +L I+ Sbjct: 1684 SLEAE----ILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIA 1739 Query: 701 KLKD------LQQSLVNSKSEEMTLQINELQKEIEILR----QEEKEKGTLEQEVQELQL 750 +L++ L+N + + TLQ++ L E+ R + + + LE++ +EL+ Sbjct: 1740 QLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKA 1799 Query: 751 KTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIK 810 K + LE +K K + + LEA+ L+++ LE K ++ R Sbjct: 1800 KLQELEGAVKSK---FKATISALEAKIGQLEEQ---LEQEAKERAAANKLVRRT------ 1847 Query: 811 SKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYAC 870 EK+++ + + ED ++ Q E++EK ++ E +E A Sbjct: 1848 --------EKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANAS 1899 Query: 871 LLKVKDDLEDSKNKQE 886 K++ +L+D+ E Sbjct: 1900 RRKLQRELDDATEANE 1915 Score = 98.6 bits (244), Expect = 1e-19 Identities = 248/1196 (20%), Positives = 484/1196 (40%), Gaps = 190/1196 (15%) Query: 1105 EQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEE--KIKELQ 1162 +Q L QR C + + H R + + + + +EEL EE K+KE Q Sbjct: 809 KQQQLSALKVLQRNCAAYLKLRHWQWWRVFTKVKPLLQVTRQEEELQAKDEELLKVKEKQ 868 Query: 1163 KIHQLELQTM--KTQETGDEGKPLHLLIGKLQK-----AVSEECSYFLQTLCSVLGEYYT 1215 + EL+ M K Q+ +E ++L +LQ A +EE L L E Sbjct: 869 TKVEGELEEMERKHQQLLEEK---NILAEQLQAETELFAEAEEMRARLAAKKQELEEILH 925 Query: 1216 PALKCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHT--------LLNKVTEEY 1267 L+ V E++ N I +NE ++Q + +QD +E + L KVT E Sbjct: 926 D-LESRVEEEEERNQ---ILQNEKKKMQAH---IQDLEEQLDEEEGARQKLQLEKVTAEA 978 Query: 1268 N------KLLVLQTRLSK-IWGQQTDGMKLEFGEENLPKEETEFLSI----HSQMTNLED 1316 ++L+L+ + SK I ++ ++ L +EE + ++ + Q + D Sbjct: 979 KIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISD 1038 Query: 1317 IDVNHKSKLSSLQDLEKTK---------LEEQVQELESLISSLQQQLKETEQNYEAEI-H 1366 ++ K + + Q+LEK K L++Q+ EL++ I L+ QL + E+ + + Sbjct: 1039 LEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALAR 1098 Query: 1367 CLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEET 1426 + L + V L + E K+ D + E E+T Sbjct: 1099 GDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDT 1158 Query: 1427 NIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVC----- 1481 +++ + + E+EVA+ + A ++T+ + +Q HA Sbjct: 1159 LDTTAAQQELRTKREQEVAE----LKKALEEETK-----NHEAQIQDMRQRHATALEELS 1209 Query: 1482 -QQEQHYFNEMKLSQDQIGFQTFE---TVDVKFKEEFKPLS----KELGEHGKEILLSNS 1533 Q EQ + L +++ G +T +VK ++ K S K+L +E+ S Sbjct: 1210 EQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVS 1269 Query: 1534 D-----------PHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLML 1582 + + D V T+ EE K F D S+ S Q +L Sbjct: 1270 EGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFA-----KDAASLESQLQDTQELL 1324 Query: 1583 NEEQLEDMR-QELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRS 1641 EE + + +RQ +E + + + Q E + E ++ L++++ L QLA Sbjct: 1325 QEETRQKLNLSSRIRQLEEEKNSLQ-------EQQEEEEEARKNLEKQVLALQSQLADTK 1377 Query: 1642 SIDNENL-----VSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVE 1696 +++L + E ++ LL++ EAL Q EK + T+ N Q E++ Sbjct: 1378 KKVDDDLGTIESLEEAKKKLLKDAEALSQRL---EEKALAYDKLEKTK----NRLQQELD 1430 Query: 1697 EQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGI 1756 + T +LD + + + SN L+K + ++L E +A E R Sbjct: 1431 DLTV---DLDHQRQ-----VASN----LEKKQKKFDQLLAEEKSISARYAEERDRAEAEA 1478 Query: 1757 LDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRN--DINMWSKV 1814 ++ +K+ S A + EA + + R E + S S D+ +N ++ + Sbjct: 1479 REKETKALSLARAL-EEALEAKEEFERQNKQLRADMEDLMS-SKDDVGKNVHELEKSKRA 1536 Query: 1815 TEEGTELSQRLVRSGFAGTEIDPENEELMLNISSR-LQAAVEKLLEAISETSSQLEHAKV 1873 E+ E R E+ +L L ++ + ++A E+ L+ E + + + + Sbjct: 1537 LEQQVE-EMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLI 1595 Query: 1874 TQT-EL---MRESFRQKQEATESLKCQE----ELRERLHEESRAREQLAVELSKAEGVID 1925 Q EL + + +Q+ A S K E +L ++ ++AR+++ +L K + + Sbjct: 1596 KQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMK 1655 Query: 1926 GYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKA 1985 Y +R+++E D + + + +L+ LEAE Q+QEE R + + Sbjct: 1656 DY-------QRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQ 1708 Query: 1986 EAGPVEQQLLQETE---KLMKEKLEVQCQAEKVRDDLQKQVKALEI-------------D 2029 E + ++ L+ EK ++ + ++ ++L+++ +E+ Sbjct: 1709 ERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDT 1768 Query: 2030 VEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMR-----KF-------------LDE 2071 + +++ Q+ + L +QN+ L+ +L+++ KF L+E Sbjct: 1769 LNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEE 1828 Query: 2072 QAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLS 2131 Q ER + +++ E++LK + F + + + A+ KE+ +K + + Sbjct: 1829 QLEQEAKERAAANKLVRRTEKKLKEI--FMQVEDERRH-----ADQYKEQMEKANARM-- 1879 Query: 2132 KEQLQRDIQERNEEIEKLEFRVRELEQALLVEDRKHFGAVEAKPELSLEVQLQAER 2187 +QL+R ++E EE + R+L++ L +D A EA LS EV R Sbjct: 1880 -KQLKRQLEEAEEEATRANASRRKLQREL--DD-----ATEANEGLSREVSTLKNR 1927 Score = 97.4 bits (241), Expect = 2e-19 Identities = 242/1190 (20%), Positives = 468/1190 (39%), Gaps = 209/1190 (17%) Query: 2718 MTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLSKSIASQTDGT 2777 +T +++L + L + KEK + + E E E E K + E I L++ + ++T+ Sbjct: 847 VTRQEEELQAKDEELLKVKEKQT--KVEGELEEMERKHQQLLEEKNI-LAEQLQAETE-- 901 Query: 2778 LKISSSNQTPQILVKNAGIQINLQSECSSEEVTEIISQFTEKIEKMQELHAAEILDMESR 2837 L + ++ K +E+ EI+ ++E+ +E + +IL E + Sbjct: 902 LFAEAEEMRARLAAKK-------------QELEEILHDLESRVEEEEERN--QILQNEKK 946 Query: 2838 ----HISETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREIC 2893 HI + E E A Q L+ E T +A I+ + +E + E +S + +++ Sbjct: 947 KMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIK--KMEEEILLLEDQNSKFIKEKKLM 1004 Query: 2894 SSDSGSDWGQGIYLTHSQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLT 2953 E R E S +K K L + + + + + L Sbjct: 1005 ------------------------EDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLE 1040 Query: 2954 ESPYSDGEDHSIQQVSEPWLEERKAYIN-TISSLKDLITKMQLQREAEVYDSSQSHESFS 3012 E E+ + Q+ LE+ K ++ + L+D I ++Q Q + Sbjct: 1041 ERLKK--EEKTRQE-----LEKAKRKLDGETTDLQDQIAELQAQID-------------- 1079 Query: 3013 DWRGELLLALQQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAME 3072 EL L L + +E + A R + L +A+ ++ L+ +I E ++++ Sbjct: 1080 ----ELKLQLAK---KEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKA 1132 Query: 3073 CLQKADR--RSLLSEIQALHAQMNGRKITLKREQE-SEKPSQELLEYNIQQKQSQMLEMQ 3129 KA++ R L E++AL ++ T +QE K QE+ E + + + + Sbjct: 1133 SRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELK-KALEEETKNHE 1191 Query: 3130 VELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVK 3189 ++ M+ R E+LS + K+ L + K LET K +K L+ + E + Sbjct: 1192 AQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESE 1251 Query: 3190 DKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRS--------EERDKEELEDLK--F 3239 K ++ L ++ + L+ L ++ +KL EE +K+ ++ K Sbjct: 1252 HKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAA 1311 Query: 3240 SLESQKQRNLQLNLLLEQQKQLLNES---QQKIESQRMLYDAQLSEEQGR-NLELQVL-- 3293 SLESQ Q + LL E+ +Q LN S +Q E + L + Q EE+ R NLE QVL Sbjct: 1312 SLESQLQDTQE--LLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLAL 1369 Query: 3294 --------------------LESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPS 3333 LE K ++ + + L + E A ++R Sbjct: 1370 QSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQEL 1429 Query: 3334 EDLLKELQKQ------LEEKHSRIVELL-----------------------NETEKYKL- 3363 +DL +L Q LE+K + +LL ET+ L Sbjct: 1430 DDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLA 1489 Query: 3364 ----DSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVY 3419 ++L+ +++ E+ + R ++ + + K +HEL+ L++Q+EE R Q+ Sbjct: 1490 RALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLE 1549 Query: 3420 KLDLEGQ-------RLQGIMQEFQKQ-----ELEREEKRESRRILYQNLNEPTTWSLTSD 3467 +L+ E Q RL+ MQ + Q + E+ E +R+L + + E L + Sbjct: 1550 ELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEA-ELEDE 1608 Query: 3468 RTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMIRQKLQCVASKLQVLPQKASE 3527 R Q+ + +K+ L ++ N + + ++L+ + ++++ ++ E Sbjct: 1609 RK-----QRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEE 1663 Query: 3528 RLQFETADDEDFIWVQE------NIDEIILQLQKLTGQ--------QGEEPSLVSPSTSC 3573 + DE F +E +++ ILQLQ+ + E L T+ Sbjct: 1664 A---RASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNS 1720 Query: 3574 GSLTERLLRQNAELTGHISQLTEEKND-------LRNMVMKLEEQIRWYRQTGAGRDNSS 3626 S LL + L I+QL EE + L + K Q+ A +++ Sbjct: 1721 ASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAA 1780 Query: 3627 RFSLNGGANIE----AIIASEKEVWNREKLTLQKSLKRAEAEVYKLKAELRNDSLLQTLS 3682 + S N +E + A +E+ K + ++ EA++ +L+ +L ++ + + Sbjct: 1781 QKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAA 1840 Query: 3683 PDSEHVTLKRIYGKYLRAESFRKALIYQKKYLLLLLGGFQECEDATLALLARMGGQPAFT 3742 T K++ +++ E R+ K+ + E +A + L R + Sbjct: 1841 NKLVRRTEKKLKEIFMQVEDERRHADQYKEQM--------EKANARMKQLKRQLEEAEEE 1892 Query: 3743 DLEVITNRPKGFTRFRSAVRVSIAISRMKFLVRRWHRVTGSVSININRDG 3792 +R K A + +SR ++ R G +S + +R G Sbjct: 1893 ATRANASRRKLQRELDDATEANEGLSREVSTLKNRLRRGGPISFSSSRSG 1942 Score = 94.4 bits (233), Expect = 2e-18 Identities = 259/1248 (20%), Positives = 500/1248 (40%), Gaps = 244/1248 (19%) Query: 908 TTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLK 967 T VK V +++ A+ E+ +V EK T ++ +LE +R+ +L + + L+EQL Sbjct: 839 TKVKPLLQVTRQEEELQAKDEELLKVKEKQT-KVEGELEEMERKHQQLLEEKNILAEQL- 896 Query: 968 QKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMT 1027 Q E+ EE+++ K+Q ELE I+ H+ V+ + + Sbjct: 897 QAETELFAEAEEMRARLAAKKQ------ELEEIL-HDLESRVEEEEER------------ 937 Query: 1028 SRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRAT 1087 N+ E K M E EE +++L L+ VT E+ ++ Sbjct: 938 -----------NQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLE---KVTAEAKIK-- 981 Query: 1088 QPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLK 1147 K+++E+ +L+ + + + + ++ S Q+ E E K+ A K Sbjct: 982 ------KMEEEILLLEDQNSKFIKEKKLMEDRIAECSS----QLAEEEEKAKNLAKIRNK 1031 Query: 1148 EELIFAQ-EEKIKELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTL 1206 +E++ + EE++K+ +K Q EL+ K + G E L I +LQ + E Sbjct: 1032 QEVMISDLEERLKKEEKTRQ-ELEKAKRKLDG-ETTDLQDQIAELQAQIDE--------- 1080 Query: 1207 CSVLGEYYTPALKCEVNAEDKENSGDYISENEDP-----------ELQDYRYEVQDFQEN 1255 LK ++ +++E G +++ ELQ E+Q+ E+ Sbjct: 1081 -----------LKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFES 1129 Query: 1256 MHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENL-PKEETEFLSIHSQMTNL 1314 NK ++ L L + + D + ++ L K E E + L Sbjct: 1130 EKASRNKAEKQKRDL---SEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKA---L 1183 Query: 1315 EDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEA---EIHCLQKR 1371 E+ NH++++ ++ T LEE ++LE + L++ +Q E E+ C K Sbjct: 1184 EEETKNHEAQIQDMRQRHATALEELSEQLEQA-KRFKANLEKNKQGLETDNKELACEVKV 1242 Query: 1372 LQAVSESTVPPSLPVDSVV------ITESDAQRTMYPGSCVK-----KNIDGTIEFSGEF 1420 LQ V + +D+ V ++E D R K N+ +E + + Sbjct: 1243 LQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKK 1302 Query: 1421 GVKEETNIVKLLEKQYQE--QLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAH 1478 G+K + L E Q Q+ +L +E + +++S SRI +E S ++ Sbjct: 1303 GIKFAKDAASL-ESQLQDTQELLQEETRQKLNLS---------SRIRQLEEEKNSLQE-- 1350 Query: 1479 AVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDI 1538 QQE+ L + + Q+ + D K K + + E E K+ LL +++ Sbjct: 1351 ---QQEEEEEARKNLEKQVLALQS-QLADTKKKVDDDLGTIESLEEAKKKLLKDAEALS- 1405 Query: 1539 PESKDCVLTISEEMFSKDKTFIVRQSIHDEIS--VSSMDASRQLMLNEEQLEDMRQELV- 1595 + E+ + DK + + E+ +D RQ+ N E+ + +L+ Sbjct: 1406 -------QRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLA 1458 Query: 1596 -------RQYQEHQQATELLRQAHMRQMERQREDQEQLQ--EEIKRLNRQLAQRSSIDNE 1646 R +E +A R+ + + R +E L+ EE +R N+QL D E Sbjct: 1459 EEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRA----DME 1514 Query: 1647 NLVSERERV--LLEELEALKQLSLAGREKLCCELRNSSTQTQNGNENQG--EVEEQTFK- 1701 +L+S ++ V + ELE K+ E++ +L + Q + + EV Q K Sbjct: 1515 DLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKA 1574 Query: 1702 --EKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDR 1759 E++L + E + RLL + +V + A +E+ + L + Sbjct: 1575 QFERDLQTRDEQ-------------NEEKKRLL--IKQVRELEAELEDERKQRALAV--- 1616 Query: 1760 SSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGT 1819 +SK + L + EA +++ + DE I K+ + Sbjct: 1617 ASKKKMEIDL---KDLEAQIEAA-----NKARDEVIKQLR-------------KLQAQMK 1655 Query: 1820 ELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELM 1879 + + L + + EI +++E + S L+A + +L E ++ + HA+ + EL Sbjct: 1656 DYQRELEEARASRDEIFAQSKESEKKLKS-LEAEILQLQEELASSERARRHAEQERDELA 1714 Query: 1880 RESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQ 1939 E + L + L R+ ++ E+L E S E L + + Sbjct: 1715 DEITNSASGKSALLDEKRRLEARI---AQLEEELEEEQSNME-----------LLNDRFR 1760 Query: 1940 EKTDIIDRLEQELLCASNRLQELEAEQQQIQEE-RELLSRQKE--------------AMK 1984 + T +D L EL + Q+ + +QQ++ + +EL ++ +E A++ Sbjct: 1761 KTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALE 1820 Query: 1985 AEAGPVEQQLLQE-------------TEKLMKEKL----EVQCQAEKVRDDLQK------ 2021 A+ G +E+QL QE TEK +KE + + A++ ++ ++K Sbjct: 1821 AKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMK 1880 Query: 2022 QVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFL 2069 Q+K + EE+ +R ++ EL D + N+ L +++ ++ L Sbjct: 1881 QLKRQLEEAEEEATRANASRRKLQRELDDATEANEGLSREVSTLKNRL 1928 Score = 56.6 bits (135), Expect = 5e-07 Identities = 84/384 (21%), Positives = 165/384 (42%), Gaps = 48/384 (12%) Query: 3337 LKELQKQLEEKHSRIVELLNETEKY-----KLDSLQTR-QQMEKDRQVHRKTLQTEQEAN 3390 L ++ +Q EE ++ ELL EK +L+ ++ + QQ+ +++ + + LQ E E Sbjct: 844 LLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELF 903 Query: 3391 TEGQK-------KMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELERE 3443 E ++ K EL+ + DL+ ++EE+ ++ L E +++Q +Q+ ++Q E E Sbjct: 904 AEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEE 963 Query: 3444 EKRESRRI-------LYQNLNEPTTWSLTSDRTRNWVLQQKI-------------EGETK 3483 R+ ++ + + E L D+ ++ ++K+ E E K Sbjct: 964 GARQKLQLEKVTAEAKIKKMEEEIL--LLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEK 1021 Query: 3484 ESNYAKLIEMNGGGTGCNHELEMIRQKLQCVASKLQVLPQKASERLQFETADDEDFI-WV 3542 N AK+ + + ++L+ Q L +KA +L ET D +D I + Sbjct: 1022 AKNLAKIRNKQ------EVMISDLEERLKKEEKTRQEL-EKAKRKLDGETTDLQDQIAEL 1074 Query: 3543 QENIDEIILQLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLR 3602 Q IDE+ LQL K ++ E ++ L+ EL I++L E+ + Sbjct: 1075 QAQIDELKLQLAK---KEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEK 1131 Query: 3603 NMVMKLEEQIRWYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRAE 3662 K E+Q R + +L+ A + + ++ K L++ K E Sbjct: 1132 ASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHE 1191 Query: 3663 AEVYKLKAELRNDSLLQTLSPDSE 3686 A++ ++ R+ + L+ LS E Sbjct: 1192 AQIQDMRQ--RHATALEELSEQLE 1213 >gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo sapiens] Length = 1972 Score = 157 bits (396), Expect = 3e-37 Identities = 224/1105 (20%), Positives = 486/1105 (43%), Gaps = 167/1105 (15%) Query: 157 LEMMESELAGKQHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQ 216 ++ E EL + ++ EL+E+ + QL E + ++++ T+L A ++ Sbjct: 854 MQAKEDELQKTKERQQKAENELKELEQKHS-----QLTEEKNLLQEQLQAETELYAEAEE 908 Query: 217 ARREKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQ 276 R + L + Q+L+ +++A A+ + QQ+L ++Q Sbjct: 909 MR----------VRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQ 958 Query: 277 LEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYE------------------------MEQ 312 LEE++ + Q +K +I L+++I V + E+ Sbjct: 959 LEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEE 1018 Query: 313 DKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELK--------------DKLTTADKL 358 ++K +N K + + E++I EL ++ +EEK EL+ +++ Sbjct: 1019 EEKAKNLTKLK-NKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQ 1077 Query: 359 LGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDI 418 + EL+ Q+ +K +E++ L + ++ + ++I++L G + +LQ+ + + + Sbjct: 1078 IAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQE-DLDSERAARNK 1136 Query: 419 VQRMEQETQRKLEQLRAELDEMYG-------------QQIVQMKQEL---IRQHMAQMEE 462 ++ +++ +LE L+ EL++ Q++ +K+ L R H AQ++E Sbjct: 1137 AEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQE 1196 Query: 463 MKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEE 522 M+ +H +E +T +Q K +++ L+ N+ LG +E Sbjct: 1197 MRQKHAQAVE-------ELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQE 1249 Query: 523 KCALQRQLEDLVEELSFSREQIQRARQTIAEQESK-----------LNEAH-KSLSTVED 570 +++LE V+EL +RAR + ++ K LNEA K++ +D Sbjct: 1250 VEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKD 1309 Query: 571 LKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAE--LER---- 624 + A + S + +EL + + N KL LE+E+N++ D++ E EA+ LER Sbjct: 1310 V-ASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHIST 1368 Query: 625 LRTQLLFSHE--EELSKLKEDLEIEHRINIEKLKDNLGIHYKQ------QIDGLQNEMSQ 676 L QL S + ++ + E LE E + +K +NL Y++ +++ +N + Q Sbjct: 1369 LNIQLSDSKKKLQDFASTVEALE-EGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQ 1427 Query: 677 KIETMQFEKDNLITKQNQLILEI-SKLKDLQQSLVNSKS-------EEMTLQINELQKEI 728 +++ + + DN Q QL+ + K + Q L K+ E + +KE Sbjct: 1428 ELDDLVVDLDN----QRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKET 1483 Query: 729 EILRQEEKEKGTLEQEVQELQLKTELLEKQMKE---KENDLQEKFAQLEAENSILK---D 782 + L + LE + +EL+ ++L+ +M++ ++D+ + +LE L+ + Sbjct: 1484 KALSLARALEEALEAK-EELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQME 1542 Query: 783 EKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENED----LKQQCIQ 838 E KT + L+ +++ +L + ++ +E++++ E+NE+ L++Q + Sbjct: 1543 EMKTQLEELEDELQATEDAKLRL--EVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHE 1600 Query: 839 LNEEIE---KQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKA 895 E+E KQR + A+K E + ++L+ + +K +++ KQ + ++++K Sbjct: 1601 YETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREE----AIKQLRKLQAQMKD 1656 Query: 896 LNEELHLQRINPTTV-------KMKSSVFDEDKTFVAETLEMGEVVEK----DTTELMEK 944 EL R + + + K+ + D + E L E K + EL E+ Sbjct: 1657 FQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEE 1716 Query: 945 L-------EVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCREL 997 L + EK L R++ L E+L+++ G + +++ V+ Q+ EQ+S Sbjct: 1717 LASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLS-----N 1771 Query: 998 EIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFE 1057 E+ + A+ +S Q+ + + EG+V KS + + +E K++ Sbjct: 1772 ELATERSTAQKNESARQQLER-QNKELRSKLHEMEGAV----KSKFKSTIAALEAKIAQL 1826 Query: 1058 NMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQR 1117 V +E++++Q L K+ Q + K+ ++ ++E+ + R++ ++ Sbjct: 1827 EEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKE-QAEKGNARVKQLKRQ 1885 Query: 1118 ICLSLVYSTHVDQVREYMENEKDKA 1142 + + S ++ R ++ E D+A Sbjct: 1886 LEEAEEESQRINANRRKLQRELDEA 1910 Score = 154 bits (389), Expect = 2e-36 Identities = 229/1044 (21%), Positives = 454/1044 (43%), Gaps = 145/1044 (13%) Query: 1935 ERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEA---MKAEAGPVE 1991 E ++Q K D + + ++ A N L+ELE + Q+ EE+ LL Q +A + AEA + Sbjct: 851 EEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMR 910 Query: 1992 QQLL---QETEKLMKEKLEVQCQAEKVR-DDLQKQVKALE---IDVEEQVSRFIELEQEK 2044 +L QE E+++ E +E + + E+ R LQ + K + +D+EEQ +E E+ Sbjct: 911 VRLAAKKQELEEILHE-MEARLEEEEDRGQQLQAERKKMAQQMLDLEEQ----LEEEEAA 965 Query: 2045 NTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKL-----EQQLKVVPR 2099 +L + +A K+LE +D+Q ER + ++ I L E++ K Sbjct: 966 RQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNL 1025 Query: 2100 FQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQA 2159 + ++H++ + +L LK++ EL K +L+ D + +E+I L+ ++ EL+ Sbjct: 1026 TKLKNKHESM-ISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQ 1084 Query: 2160 LLVEDRKHFGAV------------------EAKPELS-LEVQLQAERDAIDRKEKEITNL 2200 L ++ + A+ E + +S L+ L +ER A ++ EK+ +L Sbjct: 1085 LAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDL 1144 Query: 2201 EEQLEQFREELEN--------------KNEEVQQLHMQLEIQKKESTTRLQELEQEN--- 2243 E+LE + ELE+ + +EV L L+ + + ++QE+ Q++ Sbjct: 1145 GEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQA 1204 Query: 2244 -----------KLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQ 2292 K K +++K +++ +A + VL Q QE E + +L Q Sbjct: 1205 VEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVL----GQAKQEVEHKKKKLEAQ 1260 Query: 2293 VTKLQQQLKITTDNKVIEEKNELIRDLETQIEC---LMSDQECVKRNREEEIEQLNEVI- 2348 V +LQ K + + E N+ + L+ ++E ++++ E +++ L+ + Sbjct: 1261 VQELQS--KCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQ 1318 Query: 2349 --EKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKN 2406 ++L QE S L EE +SL+ QLD + K LE+ + T N +++ K Sbjct: 1319 DTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKK 1378 Query: 2407 VLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDAL 2466 L++ + L + KR ++ +E + E A D L K K L+ L +D + Sbjct: 1379 KLQDFASTVEALEE---GKKRFQKEIENLTQQYEEKA-AAYDKLEKTKNRLQQEL-DDLV 1433 Query: 2467 KSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETE 2526 L+NQ S E + +LL E +S+K D +++ + E Sbjct: 1434 VDLDNQRQLVSNLEKKQRKF----DQLLAEEKNISSK----------YADERDRAEAEAR 1479 Query: 2527 MLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLRE 2586 + K ++L + +EE AL ++ +LE + K ++ S + N+ L + + Sbjct: 1480 EKETKALSLARALEE----ALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKR 1535 Query: 2587 ------DELGSDISALTLRISELESQVVEMHTSLILEKEQVE-IAEKNVLEKEKKLLELQ 2639 +E+ + + L + E + + ++ K Q E + + E+K +LQ Sbjct: 1536 ALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQ 1595 Query: 2640 KLLE------GNEKKQR---EKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAES 2690 + L +E+KQR KK+ D++ L+ + E +L L+A+ Sbjct: 1596 RQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEA-IKQLRKLQAQM 1654 Query: 2691 VATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAK--EKLSILEKEDET 2748 + EL + +++ E SL+ DL Q+++ LA A+ K + LEKE+ Sbjct: 1655 KDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEE-- 1712 Query: 2749 EVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSS-E 2807 L++ +AS G + + ++ ++ + A ++ L+ E + E Sbjct: 1713 -----------------LAEELASSLSG--RNALQDEKRRLEARIAQLEEELEEEQGNME 1753 Query: 2808 EVTEIISQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVI 2867 +++ + + T++ E++ A E ++ S + L+R++ L E G +K+ Sbjct: 1754 AMSDRVRKATQQAEQLSNELATE-RSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKF 1812 Query: 2868 QCLRSKEGSSIPELAHSDAYQTRE 2891 + + + I +L + RE Sbjct: 1813 KSTIAALEAKIAQLEEQVEQEARE 1836 Score = 154 bits (388), Expect = 2e-36 Identities = 232/1212 (19%), Positives = 531/1212 (43%), Gaps = 166/1212 (13%) Query: 225 MREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLL 284 ++ L++T Q +++Q + +LQ ++ + + +L + +Q+ QL E+ +LL Sbjct: 841 VKPLLQVTRQEEEMQAKEDELQKTKERQQKAEN----ELKELEQK----HSQLTEEKNLL 892 Query: 285 EDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKK 344 ++ LQ + ++Y ++ +V + K+ QE E I+ E+ ++ EEE + Sbjct: 893 QEQ-------------LQAETELYAEAEEMRVRLAAKK--QELEEILHEMEARLEEEEDR 937 Query: 345 TLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEEL 404 +L+ + + + +L+EQ+ ++ + ++LE ++ K ++ +EI + +L Sbjct: 938 GQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKL 997 Query: 405 QKRNHKDSQFETDIVQRM--EQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEE 462 K + +D+ + E+E + L +L+ + + M + V++K+E + ++E+ Sbjct: 998 SKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKE--EKSRQELEK 1055 Query: 463 MKTRHKGEMENALRSYSNITVNEDQIKL--------MNVAINELNIKLQDTNSQKEKLKE 514 +K + +G+ + +++ ++K+ + A+ L+ ++ N+ +K++E Sbjct: 1056 LKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRE 1115 Query: 515 ELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAE 574 L+ + DL E+L R AR +Q+ L E ++L T + + Sbjct: 1116 -----------LEGHISDLQEDLDSER----AARNKAEKQKRDLGEELEALKTELE---D 1157 Query: 575 IVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHE 634 + ++ +++EL K E EVT K LD S EA+++ +R + H Sbjct: 1158 TLDSTATQQELRAKREQEVTVLK-----------KALDEETRSHEAQVQEMRQK----HA 1202 Query: 635 EELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQ 694 + + +L E LE ++ K NL + KQ ++ +++ ++ + K + K+ + Sbjct: 1203 QAVEELTEQLE-----QFKRAKANLDKN-KQTLEKENADLAGELRVLGQAKQEVEHKKKK 1256 Query: 695 LILEISKLKDLQQSLVNSKSEEMTLQINELQKEIE----ILRQEEKEKGTLEQEV----Q 746 L ++ +L+ +++ E+ ++++LQ E+E +L + E + L ++V Sbjct: 1257 LEAQVQELQSKCSDGERARA-ELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSS 1315 Query: 747 ELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFL 806 +LQ ELL+++ ++K N + K QLE E + L+D+ L++ ++ + + + + Sbjct: 1316 QLQDTQELLQEETRQKLN-VSTKLRQLEEERNSLQDQ---LDEEMEAKQNLERHISTLNI 1371 Query: 807 DSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQE 866 SK K + +E L E +K F+ + L + Sbjct: 1372 QLSDSKKKLQDFASTVEALEE-------------------------GKKRFQKEIENLTQ 1406 Query: 867 EYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAE 926 +Y D LE +KN+ + E L L +L QR + ++ K FD+ +AE Sbjct: 1407 QYEEKAAAYDKLEKTKNRLQQE----LDDLVVDLDNQRQLVSNLEKKQRKFDQ---LLAE 1459 Query: 927 TLEMGE--VVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLK 984 + E+D E + + TK L L++ L + E ++ L E++ L Sbjct: 1460 EKNISSKYADERDRAEAEAREKETK--ALSLARALEEALEAKEELERTNKMLKAEMEDLV 1517 Query: 985 QEKEQVSLRCRELEIIINHNRA--ENVQSCDTQVSSLLDGV---------VTMTSRGAEG 1033 K+ V ELE RA ++ TQ+ L D + + + + +G Sbjct: 1518 SSKDDVGKNVHELE---KSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKG 1574 Query: 1034 SVSK---VNKSFGEESKIMVEDKVSFENMTVGEESKQEQLIL---DHLPSVTKESSLRAT 1087 + EE + ++ ++ + +E KQ L L K+ L+A Sbjct: 1575 QFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQAD 1634 Query: 1088 QPSE-NDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSL 1146 + ++ K+L L+++ D + ++E R +++T + ++ E D L L Sbjct: 1635 SAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEAD--LMQL 1692 Query: 1147 KEELIFAQE-EKIKELQK---IHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYF 1202 +E+L A+ K +L+K +L DE + L I +L++ + EE Sbjct: 1693 QEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEE---- 1748 Query: 1203 LQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLLNK 1262 Q + + A + ++ + ++ + Q + ++ + +H + Sbjct: 1749 -QGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGA 1807 Query: 1263 VTEEY-NKLLVLQTRLSKIWGQ-QTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVN 1320 V ++ + + L+ +++++ Q + + + + ++L +++ + I Q+ + + Sbjct: 1808 VKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQ 1867 Query: 1321 HKSKL----SSLQDLEK--TKLEEQVQELESLISSLQQQLKETEQNYEA---EIHCLQKR 1371 +K + + ++ L++ + EE+ Q + + LQ++L E ++ EA E++ L+ + Sbjct: 1868 YKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSK 1927 Query: 1372 LQAVSESTVPPS 1383 L+ +E++ PS Sbjct: 1928 LRRGNETSFVPS 1939 Score = 150 bits (380), Expect = 2e-35 Identities = 227/1071 (21%), Positives = 462/1071 (43%), Gaps = 156/1071 (14%) Query: 1563 QSIHDEISV---SSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLR--QAHMRQME 1617 + + DEI V + S++ L EE++ D+ L + ++ + T+L ++ + ++E Sbjct: 981 KKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELE 1040 Query: 1618 RQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCE 1677 + + +E+ ++E+++L R+L +S +E + L ++ LK E+L Sbjct: 1041 VRLKKEEKSRQELEKLKRKLEGDASDFHEQIAD-----LQAQIAELKMQLAKKEEELQAA 1095 Query: 1678 LRNSSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLE 1737 L + N ++ +EL+ D+ E L +ER A KA + + E Sbjct: 1096 LARLDDEIAQKNNALKKI-------RELEGHISDLQ-EDLDSERAARNKAEKQKRDLGEE 1147 Query: 1738 VVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPS 1797 + +E+T LD ++ Q + + E E +V +E TR + + Sbjct: 1148 LEALKTELEDT--------LDSTATQQELRA---KREQEVTVLKKALDEETRSHEAQVQE 1196 Query: 1798 YSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKL 1857 M K + EL+++L + A +D + L + A + Sbjct: 1197 ------------MRQKHAQAVEELTEQLEQFKRAKANLDKNKQTL-----EKENADLAGE 1239 Query: 1858 LEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVEL 1917 L + + ++EH K ++E + + ++ + + EL +++H+ E + L Sbjct: 1240 LRVLGQAKQEVEHKKKKLEAQVQEL---QSKCSDGERARAELNDKVHKLQNEVESVTGML 1296 Query: 1918 SKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLS 1977 ++AEG A + Q+Q+ +++ ++ L S +L++LE E+ +Q++ + Sbjct: 1297 NEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEM 1356 Query: 1978 RQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRF 2037 K+ ++ + QL +KL V+ E+ + QK+++ L EE+ + + Sbjct: 1357 EAKQNLERHISTLNIQLSDSKKKLQDFASTVEA-LEEGKKRFQKEIENLTQQYEEKAAAY 1415 Query: 2038 IELEQEKN-------TELMDLRQQNQALEKQLEKMRKF----LDEQAIDREH--ERDVFQ 2084 +LE+ KN ++DL Q Q + +K RKF +E+ I ++ ERD + Sbjct: 1416 DKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAE 1475 Query: 2085 QEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNE 2144 E ++ E + + R + E+E+ LK + + +L+ SK+ + +++ E + Sbjct: 1476 AEAREKETKALSLARALEEALEAKEELERTNKMLKAEME---DLVSSKDDVGKNVHELEK 1532 Query: 2145 EIEKLEFRVRELEQALLVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQL 2204 LE ++ E++ L LE +LQA DA R E N++ Sbjct: 1533 SKRALETQMEEMKTQL----------------EELEDELQATEDAKLRLE---VNMQALK 1573 Query: 2205 EQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMS 2264 QF +L+ ++E+ ++ QL+ Q E T L++ ++ L +KL +K+ + Sbjct: 1574 GQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKD---LE 1630 Query: 2265 TQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNK-----VIEEKNELIRDL 2319 Q + G+ +E ++ +L Q+ Q++L+ ++ +E + + L Sbjct: 1631 LQADSAIKGR-----EEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSL 1685 Query: 2320 ETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQ 2379 E + L D +R R++ + E+ E+L L+ ++L +E K + Sbjct: 1686 EADLMQLQEDLAAAERARKQADLEKEELAEELASSLS--------GRNALQDE----KRR 1733 Query: 2380 LDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIP 2439 L+ IA+ LE+++E M M + +++ + QL+ EL + ER + +K +S Sbjct: 1734 LEARIAQ---LEEELEEEQGNMEAMSDRVRKATQQAEQLSNELAT---ERSTAQKNES-- 1785 Query: 2440 ENSVNVAIDHLSKDKPELEVVL--TEDALKSLENQTYFKSFEENGKGSIINLETRLLQLE 2497 A L + EL L E A+KS K +I LE ++ QLE Sbjct: 1786 ------ARQQLERQNKELRSKLHEMEGAVKS------------KFKSTIAALEAKIAQLE 1827 Query: 2498 STVSAKDLELTQCYKQIKDMQEQGQFETEMLQ----KKIVNLQKIVEEKVAAALVSQI-- 2551 V + E K +K Q+ + + +LQ +K+ K EK A V Q+ Sbjct: 1828 EQVEQEAREKQAATKSLK--QKDKKLKEILLQVEDERKMAEQYKEQAEK-GNARVKQLKR 1884 Query: 2552 QLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLRE--DELGSDISALTLRI 2600 QLE +E ++Q I++ + + L++ E + +G +++AL ++ Sbjct: 1885 QLEEAEE------ESQRINANRRKLQ-RELDEATESNEAMGREVNALKSKL 1928 Score = 143 bits (360), Expect = 4e-33 Identities = 248/1144 (21%), Positives = 503/1144 (43%), Gaps = 154/1144 (13%) Query: 2386 EKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNV 2445 E A E +++ E +N LKE K +QLT+E L+ + ++ ++ + E + V Sbjct: 853 EMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEE-MRV 911 Query: 2446 AIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKG---SIINLETRLLQLESTVSA 2502 L+ K ELE +L E + E + + + K +++LE +L + E+ Sbjct: 912 ---RLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQK 968 Query: 2503 KDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEA-VQEYAK 2561 LE +IK ++++ + K+ +K++EE+++ + + E + K Sbjct: 969 LQLEKVTAEAKIKKLEDEILVMDDQ-NNKLSKERKLLEERISDLTTNLAEEEEKAKNLTK 1027 Query: 2562 FCQDNQTISSE------PERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLI 2615 ++++ SE E + Q L +L+ +L D S +I++L++Q+ E+ L Sbjct: 1028 LKNKHESMISELEVRLKKEEKSRQELEKLKR-KLEGDASDFHEQIADLQAQIAELKMQLA 1086 Query: 2616 LEKEQV---------EIAEKN-----VLEKEKKLLELQKLLEGNE--KKQREKEKKRSPQ 2659 ++E++ EIA+KN + E E + +LQ+ L+ + + EK+K+ + Sbjct: 1087 KKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGE 1146 Query: 2660 DVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMT 2719 ++E LKT ELE +S AT+ EL + +E+ + ++ L +ET Sbjct: 1147 ELEALKT---------------ELEDT-LDSTATQQELRAKREQEVTVLKKALDEETR-- 1188 Query: 2720 SLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKA-CMFEPLPIKLSKSIASQTDGTL 2778 S + + ++R A+A E+L+ ++++ K+A + L K A Sbjct: 1189 SHEAQVQEMRQKHAQAVEELT-------EQLEQFKRAKANLDKNKQTLEKENADLAGELR 1241 Query: 2779 KISSSNQTPQILVKNAGIQIN-LQSECSSEEVTEIISQFTEKIEKMQ---ELHAAEILDM 2834 + + Q + K Q+ LQS+CS E ++ +K+ K+Q E + + Sbjct: 1242 VLGQAKQEVEHKKKKLEAQVQELQSKCSDGERAR--AELNDKVHKLQNEVESVTGMLNEA 1299 Query: 2835 ESRHIS---ETETLKREHYVAVQLLKEECGTLKAVIQCLRS--KEGSSIPELAHSDAYQT 2889 E + I + +L + +LL+EE V LR +E +S+ + + Sbjct: 1300 EGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAK 1359 Query: 2890 REICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESESATDSFPKKIKGLLR------AVH 2943 + + S + I L+ S+ E E F K+I+ L + A + Sbjct: 1360 QNLERHISTLN----IQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAY 1415 Query: 2944 NEGMQVLSLTESPYSD---GEDHSIQQVSEPWLEERKAYINTISSLKDLITKMQLQR--- 2997 ++ + + + D D+ Q VS ++RK + ++ K++ +K +R Sbjct: 1416 DKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRK-FDQLLAEEKNISSKYADERDRA 1474 Query: 2998 EAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTALGTTDAVGL----- 3052 EAE + S + E L A ++ LE + +L A +L + + D VG Sbjct: 1475 EAEAREKETKALSLARALEEALEAKEE--LERTNKMLKAEMEDLVS--SKDDVGKNVHEL 1530 Query: 3053 ---LNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEI--QALHAQMNGRKITLKREQESE 3107 LE +++E + + + LQ + L E+ QAL Q R + + EQ E Sbjct: 1531 EKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFE-RDLQARDEQNEE 1589 Query: 3108 KPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLEL 3167 K +Q Q Q+ E + EL + +Q + +L+ +L +L+ Sbjct: 1590 KR---------RQLQRQLHEYETELEDER-------KQRALAAAAKKKLEGDLKDLELQA 1633 Query: 3168 ETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSE 3227 ++ +K + + +K+L + ++KD E+ + + SR+ +A KE K +S Sbjct: 1634 DSAIKGREEAIKQLRKLQAQMKDFQRELE--------DARASRDEIFATAKENEKKAKSL 1685 Query: 3228 ERDKEEL-EDLKFSLESQKQRNLQLNLLLEQQ------KQLLNESQQKIESQRMLYDAQL 3280 E D +L EDL + ++KQ +L+ L E+ + L + ++++E++ + +L Sbjct: 1686 EADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEEL 1745 Query: 3281 SEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKEL 3340 EEQG +E+ R+R+ + + +L +L + T Q +E ++L Sbjct: 1746 EEEQGN-------MEAMSDRVRKATQQAE---QLSNELATERSTAQK-----NESARQQL 1790 Query: 3341 QKQLEEKHSRIVELLNETE---KYKLDSLQTR-QQMEKDRQVHRKTLQTEQEANTEGQKK 3396 ++Q +E S++ E+ + K + +L+ + Q+E+ + + Q ++ + KK Sbjct: 1791 ERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKK 1850 Query: 3397 MHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELEREEKRESRRILYQNL 3456 + E+ +VED ++ E+ ++Q K R++ + ++ ++ E E + +RR L + L Sbjct: 1851 LKEILLQVEDERKMAEQYKEQAEK---GNARVKQLKRQLEEAEEESQRINANRRKLQREL 1907 Query: 3457 NEPT 3460 +E T Sbjct: 1908 DEAT 1911 Score = 135 bits (339), Expect = 1e-30 Identities = 239/1142 (20%), Positives = 497/1142 (43%), Gaps = 115/1142 (10%) Query: 1976 LSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVS 2035 ++RQ+E M+A+ E +L + E+ K + E++ + E+ L ++ L+ ++ + Sbjct: 847 VTRQEEEMQAK----EDELQKTKERQQKAENELK-ELEQKHSQLTEEKNLLQEQLQAETE 901 Query: 2036 RFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDR----EHERDVFQQEIQKLE 2091 + E E+ + + L + Q LE+ L +M L+E+ DR + ER Q++ LE Sbjct: 902 LYAEAEEMR----VRLAAKKQELEEILHEMEARLEEEE-DRGQQLQAERKKMAQQMLDLE 956 Query: 2092 QQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEF 2151 +QL+ + + Q ++E++ K K + E+L+ +Q + +ER + LE Sbjct: 957 EQLE-----EEEAARQKLQLEKVTAEAKIKKLE-DEILVMDDQNNKLSKER----KLLEE 1006 Query: 2152 RVRELEQALLVEDRKHFGAVEAKPE-----LSLEVQLQAERDAIDRKEKEITNLEEQLEQ 2206 R+ +L L E+ K + K + LEV+L+ E + EK LE Sbjct: 1007 RISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASD 1066 Query: 2207 FREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQ 2266 F E++ + ++ +L MQL +++E L L+ E + ++K I+E + + Sbjct: 1067 FHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKK----IRELEGHISD 1122 Query: 2267 DQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECL 2326 Q L + A + ++ + D L E++ L+ +L+ T D+ +++ R+ E + Sbjct: 1123 LQEDLDSERAARNKAEKQKRD-LGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKK 1181 Query: 2327 MSDQEC---------VKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLK 2377 D+E +++ + +E+L E +E+ ++ AN+ + N +L +E L Sbjct: 1182 ALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDK----NKQTLEKENADLA 1237 Query: 2378 HQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQS 2437 +L V+ K +E + + ++ +++ + +L ++ L+ E ESV + + Sbjct: 1238 GELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLN 1297 Query: 2438 IPE-NSVNVAID--HLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRL- 2493 E ++ +A D LS + + +L E+ + L T + EE L+ + Sbjct: 1298 EAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEME 1357 Query: 2494 --LQLESTVSAKDLELTQCYKQIKDMQ------EQGQFETEMLQKKIVNLQKIVEEKVAA 2545 LE +S +++L+ K+++D E+G+ + QK+I NL + EEK AA Sbjct: 1358 AKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGK---KRFQKEIENLTQQYEEKAAA 1414 Query: 2546 ALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELES 2605 +LE + + D+ + + +R + NL + + + +L + Sbjct: 1415 ----YDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQR------------KFDQLLA 1458 Query: 2606 QVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLK 2665 + + + E+++ AE EKE K L L + LE + + E E+ E+ Sbjct: 1459 EEKNISSKYADERDR---AEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEM-- 1513 Query: 2666 TTTELFHSNEESG-FFNELE----ALRAESVATKAELASYKEKAEKLQEELLVKETNMTS 2720 +L S ++ G +ELE AL + K +L +++ + ++ L E NM + Sbjct: 1514 --EDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQA 1571 Query: 2721 L----QKDLSQVRDHLAEAKEKLSILEKEDETEVQ-ESKKACMFEPLPIKLS---KSIAS 2772 L ++DL + E + +L E ETE++ E K+ + KL K + Sbjct: 1572 LKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLEL 1631 Query: 2773 QTDGTLK--ISSSNQTPQILVKNAGIQINLQSECSSEEVTEIISQFTEKIEKMQELHAAE 2830 Q D +K + Q ++ + Q L+ +S + EI + E +K + L A+ Sbjct: 1632 QADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRD--EIFATAKENEKKAKSLE-AD 1688 Query: 2831 ILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTR 2890 ++ ++ ++ E +++ + + L EE + + L+ ++ +A + Sbjct: 1689 LMQLQ-EDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEE 1747 Query: 2891 EICSSDSGSD-WGQGIYLTHSQGFDIASE-GRGEESESATDSFPKKIKGLLRAVHNEGMQ 2948 E + ++ SD + ++A+E +++ESA ++ K L +H Sbjct: 1748 EQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGA 1807 Query: 2949 VLSLTESPYS--DGEDHSIQQVSEPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQ 3006 V S +S + + + +++ E E++A ++ + ++ LQ E E + Q Sbjct: 1808 VKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQ 1867 Query: 3007 SHESFSDWRGEL-LLALQQVFLEERSVLLAAFRTEL-----TALGTTDAVGL-LNCLEQR 3059 E + L Q EE S + A R +L A + +A+G +N L+ + Sbjct: 1868 YKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSK 1927 Query: 3060 IQ 3061 ++ Sbjct: 1928 LR 1929 Score = 133 bits (334), Expect = 4e-30 Identities = 280/1347 (20%), Positives = 551/1347 (40%), Gaps = 217/1347 (16%) Query: 414 FETDIVQRMEQETQRKLEQLRAELDEMYG------------QQIVQMKQELIRQHMAQME 461 F T ++ +E+E K+ + M QQ+ MK +I+++ A Sbjct: 770 FRTGVLAHLEEERDLKITDVIMAFQAMCRGYLARKAFAKRQQQLTAMK--VIQRNCAAYL 827 Query: 462 EMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILE 521 +++ + ++ +T E++++ + + + Q ++ ++L+++ + E Sbjct: 828 KLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTE 887 Query: 522 EKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVED----LKAEIVS 577 EK LQ QL+ E + + E R E E L+E L ED L+AE Sbjct: 888 EKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKK 947 Query: 578 ASESRKELELK-HEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEE 636 ++ +LE + E E K++LE + + EA++++L ++L ++ Sbjct: 948 MAQQMLDLEEQLEEEEAARQKLQLEKV-------------TAEAKIKKLEDEILVMDDQN 994 Query: 637 LSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLI 696 KE +E RI+ L NL +++ L ++ K E+M E + + K+ + Sbjct: 995 NKLSKERKLLEERIS--DLTTNLA-EEEEKAKNL-TKLKNKHESMISELEVRLKKEEKSR 1050 Query: 697 LEISKLKDLQQSLVNSKSEEMT-LQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELL 755 E+ KLK + + E++ LQ + ++++ ++EE+ + L + E+ K L Sbjct: 1051 QELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNAL 1110 Query: 756 EK--QMKEKENDLQEKF-AQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSK 812 +K +++ +DLQE ++ A N K ++ E++ + T + LDS ++ Sbjct: 1111 KKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDT-----LDSTATQ 1165 Query: 813 SK-DSVWEKEIEIL---IEEN--------EDLKQQCIQLNEEIEKQRNTFSFAEKNFEVN 860 + + E+E+ +L ++E ++++Q+ Q EE+ +Q F A+ N + N Sbjct: 1166 QELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKN 1225 Query: 861 YQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDED 920 Q L++E A L L + KQE+E+K K ++ +++S D + Sbjct: 1226 KQTLEKENADLAGELRVL--GQAKQEVEHKKK-----------KLEAQVQELQSKCSDGE 1272 Query: 921 KTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEV 980 + AE + ++ + + L + + ++L++ ++ LS QL+ L EE Sbjct: 1273 RA-RAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQ---ELLQEET 1328 Query: 981 KSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNK 1040 + +K VS + R+LE E S Q+ ++ + E +S +N Sbjct: 1329 R----QKLNVSTKLRQLE--------EERNSLQDQLDEEME-----AKQNLERHISTLNI 1371 Query: 1041 SFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELN 1100 + K + + + E + G++ Q++ + ++T++ +A + DKL+K N Sbjct: 1372 QLSDSKKKLQDFASTVEALEEGKKRFQKE-----IENLTQQYEEKA---AAYDKLEKTKN 1423 Query: 1101 VLKSEQNDLRLQMEAQRICLSLVYSTH--VDQVREYMENEKDKALCSLKEELIFAQEEKI 1158 L+ E +DL + ++ QR +S + DQ+ +N K A+E++ Sbjct: 1424 RLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKET 1483 Query: 1159 KELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPAL 1218 K L LE + ++ +E + K+ KA E Sbjct: 1484 KALSLARALE-EALEAKEELER-------TNKMLKAEME--------------------- 1514 Query: 1219 KCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEY----NKLLVLQ 1274 D +S D + +N EL+ + ++ E M T L ++ +E + L L+ Sbjct: 1515 -------DLVSSKDDVGKNVH-ELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLE 1566 Query: 1275 TRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKT 1334 + + GQ ++ E+N K +H T LED + K +L K Sbjct: 1567 VNMQALKGQFERDLQAR-DEQNEEKRRQLQRQLHEYETELED-----ERKQRALAAAAKK 1620 Query: 1335 KLEEQVQELE----SLISSLQQQLKETEQNYEAEIHCLQKRLQ------------AVSES 1378 KLE +++LE S I ++ +K+ + +A++ Q+ L+ A Sbjct: 1621 KLEGDLKDLELQADSAIKGREEAIKQL-RKLQAQMKDFQRELEDARASRDEIFATAKENE 1679 Query: 1379 TVPPSLPVDSVVITE--SDAQRTMYPGSCVKKNIDGTI--EFSGEFGVKEETNIVKLLEK 1434 SL D + + E + A+R K+ + + SG +++E ++ Sbjct: 1680 KKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIA 1739 Query: 1435 QYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMKLS 1494 Q +E+LEEE G E A S + QQ + NE L+ Sbjct: 1740 QLEEELEEE---------------------QGNME--AMSDRVRKATQQAEQLSNE--LA 1774 Query: 1495 QDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEMFS 1554 ++ Q E+ + + + K L +L E + E+K L E + Sbjct: 1775 TERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEA 1834 Query: 1555 KDKTFIVRQSIHDEISVSSMDAS-RQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHM 1613 ++K + S+ D ++++L Q+ED R ++ QY+E + A + Sbjct: 1835 REKQAATK-------SLKQKDKKLKEILL---QVEDER-KMAEQYKEQAEK----GNARV 1879 Query: 1614 RQMERQREDQEQLQEEIKRLNRQLAQRSSIDNE-NLVSERERVLLEELEALKQLSLAGRE 1672 +Q++RQ E+ E EE +R+N A R + E + +E + E+ ALK G E Sbjct: 1880 KQLKRQLEEAE---EESQRIN---ANRRKLQRELDEATESNEAMGREVNALKSKLRRGNE 1933 Query: 1673 KLCCELRNSSTQTQNGNENQGEVEEQT 1699 R S + N + E E T Sbjct: 1934 TSFVPSRRSGGRRVIENADGSEEETDT 1960 Score = 131 bits (329), Expect = 1e-29 Identities = 213/1071 (19%), Positives = 450/1071 (42%), Gaps = 162/1071 (15%) Query: 2 EDEERQKKLEAGKAKLAQFRQRKAQSDGQSPSKKQKKKRKTSSSKHDVSAHHDLNIDQSQ 61 E+E+R ++L+A + K+AQ + + + +QK + + +++ + D + Sbjct: 933 EEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDD 992 Query: 62 CNEMYINSSQRVESTVIPESTIMRTLHSGEITSHEQGFSVELESEISTTADDCSSEVNGC 121 N + +E + +T E + + ES IS E Sbjct: 993 QNNKLSKERKLLEERISDLTT--NLAEEEEKAKNLTKLKNKHESMISELEVRLKKE---- 1046 Query: 122 SFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHEIEELNRELEEM 181 ++ + L+ + G + EQ A D + ++ +LA K+ E++ L++ Sbjct: 1047 ---EKSRQELEKLKRKLEGDASDFHEQIA-DLQAQIAELKMQLAKKEEELQAALARLDD- 1101 Query: 182 RVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQIQ 241 + L++++E E G I+ L +L R +++ ++ +L E+ + L+ + Sbjct: 1102 EIAQKNNALKKIRELE-------GHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTE 1154 Query: 242 F----------QQLQASE-----TLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLED 286 Q+L+A L+ + T + Q ++ H Q +EE LE Sbjct: 1155 LEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQ 1214 Query: 287 YQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEK----ETIIEELNTKIIEEE 342 +++ K + L+++ ++ + +V K+E++ K E ++EL +K + E Sbjct: 1215 FKRAKANLDKNKQTLEKENA--DLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGE 1272 Query: 343 KKTLELKDK-------LTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIK 395 + EL DK + + +L E + + ++ +++ ++ +L ++++ EE + Sbjct: 1273 RARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQE---LLQEETR 1329 Query: 396 QLMGTVEELQKRNHKDSQFETDIVQRME--QETQRKLEQLRAELDEMYGQQIVQMKQELI 453 Q + +L++ + + + + + ME Q +R + L +L + + K + Sbjct: 1330 QKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDS------KKKLQDF 1383 Query: 454 RQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQI-KLMNVAINELNIKLQDTNSQKEKL 512 + +EE K R + E+EN + Y D++ K N EL+ + D ++Q++ + Sbjct: 1384 ASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLV 1443 Query: 513 KEELGLILEEKCALQRQLEDLV-EELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDL 571 LE+K QR+ + L+ EE + S + + AE K K+LS L Sbjct: 1444 SN-----LEKK---QRKFDQLLAEEKNISSKYADERDRAEAEAREK---ETKALSLARAL 1492 Query: 572 KAEIVSASESRKELELKHEAEVTNYKIKLEM--LEKEKNAV------LDRMAESQEAELE 623 + + LE K E E TN +K EM L K+ V L++ + E ++E Sbjct: 1493 E----------EALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQME 1542 Query: 624 RLRTQLLFSHEEELSKLKEDLEIEHRINIEKLK----------DNLGIHYKQQIDGLQNE 673 ++TQL E+ + ED ++ +N++ LK D ++Q+ +E Sbjct: 1543 EMKTQL--EELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHE 1600 Query: 674 MSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSE------EMTLQINELQKE 727 ++E + ++ + +L ++ L+ S + + E ++ Q+ + Q+E Sbjct: 1601 YETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRE 1660 Query: 728 IEILR-----------QEEKEKGTLEQEVQELQ---LKTELLEKQMKEKENDLQEKFAQL 773 +E R + EK+ +LE ++ +LQ E KQ ++ +L E+ A Sbjct: 1661 LEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASS 1720 Query: 774 EAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLK 833 + + L+DEK+ LE + +EE + +E + + Sbjct: 1721 LSGRNALQDEKRRLEARIAQLEEELEEE-----------------QGNMEAMSDRVRKAT 1763 Query: 834 QQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKL 893 QQ QL+ E+ +R+T A+KN E Q+L+ + +++ L + + + ++KS + Sbjct: 1764 QQAEQLSNELATERST---AQKN-ESARQQLERQNK---ELRSKLHEMEGAVKSKFKSTI 1816 Query: 894 KAL-----------NEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELM 942 AL +E ++ ++K K E V + +M E ++ + Sbjct: 1817 AALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGN 1876 Query: 943 EKLEVTKR---EKLELSQRLSDLSEQLKQKHGEISFLNE----EVKSLKQE 986 +++ KR E E SQR++ +L+++ E + NE EV +LK + Sbjct: 1877 ARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSK 1927 Score = 117 bits (292), Expect = 3e-25 Identities = 242/1207 (20%), Positives = 495/1207 (41%), Gaps = 201/1207 (16%) Query: 624 RLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQF 683 +++ L + +EE + KED ++K K+ +Q+ + E+ QK + Sbjct: 840 KVKPLLQVTRQEEEMQAKED-------ELQKTKER-----QQKAENELKELEQKHSQLTE 887 Query: 684 EKDNLITKQNQLILEI-SKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGT-L 741 EK NL+ +Q Q E+ ++ ++++ L K E + E+ E+E +EE+++G L Sbjct: 888 EK-NLLQEQLQAETELYAEAEEMRVRLAAKKQE-----LEEILHEMEARLEEEEDRGQQL 941 Query: 742 EQEVQELQLKTELLEKQMKEKE-----------------NDLQEKFAQLEAENSILKDEK 784 + E +++ + LE+Q++E+E L+++ ++ +N+ L E+ Sbjct: 942 QAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKER 1001 Query: 785 KTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIE 844 K LE+ + T EE + K K+K E+E+ +++ E +Q+ +L ++E Sbjct: 1002 KLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLE 1061 Query: 845 KQRNTFSFAEKNFEVNYQEL--------QEEYACLLKVKDDLEDSKN--KQELEYKSKLK 894 + F + + EL +E A L ++ D++ N K+ E + + Sbjct: 1062 GDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHIS 1121 Query: 895 ALNEELHLQRINPTTVKMKSSVFDED----KTFVAETLEMGEVVEKDTTELMEKLEVTKR 950 L E+L +R + + E+ KT + +TL+ ++ + +++ V K+ Sbjct: 1122 DLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKK 1181 Query: 951 EKLELSQRLSDLSEQLKQKHGE-ISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENV 1009 E ++ ++++QKH + + L E+++ K+ K + + LE EN Sbjct: 1182 ALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLE-------KENA 1234 Query: 1010 Q-SCDTQVSSLLDGVVTMTSRGAEGSVSKVNK--SFGEESKIMVEDKV--------SFEN 1058 + + +V V + E V ++ S GE ++ + DKV S Sbjct: 1235 DLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTG 1294 Query: 1059 MTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRI 1118 M E K +L D + S L+ TQ ++ +++LNV LR Q+E +R Sbjct: 1295 MLNEAEGKAIKLAKD---VASLSSQLQDTQELLQEETRQKLNV----STKLR-QLEEERN 1346 Query: 1119 CLSLVYSTHVDQVREYMENEK--DKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQE 1176 L DQ+ E ME ++ ++ + +L +L + K+LQ T E Sbjct: 1347 SLQ-------DQLDEEMEAKQNLERHISTLNIQL----SDSKKKLQDF-------ASTVE 1388 Query: 1177 TGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDK-ENSGDYIS 1235 +EGK + QK + E T + + A DK E + + + Sbjct: 1389 ALEEGKK------RFQKEI----------------ENLTQQYEEKAAAYDKLEKTKNRLQ 1426 Query: 1236 ENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEE 1295 + D + D D Q + + L K ++++LL + +S + + D + E E+ Sbjct: 1427 QELDDLVVDL-----DNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREK 1481 Query: 1296 -----NLPKEETEFLSIHSQM--------TNLEDIDVNHKSKLSSLQDLEKTK--LEEQV 1340 +L + E L ++ +ED+ + ++ +LEK+K LE Q+ Sbjct: 1482 ETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQM 1541 Query: 1341 QELESLISSLQQQLKETEQ-------NYEAEIHCLQKRLQAVSEST------VPPSLPVD 1387 +E+++ + L+ +L+ TE N +A ++ LQA E + L Sbjct: 1542 EEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEY 1601 Query: 1388 SVVITESDAQRTMYPGSCVKKNIDG---TIEFSGEFGVKEETNIVKLLE------KQYQE 1438 + + QR + + KK ++G +E + +K +K L K +Q Sbjct: 1602 ETELEDERKQRAL--AAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQR 1659 Query: 1439 QLEEEVAKVIVSMSIAFAQQTELSRISGG----KENTASSKQAHAVCQQEQHYFNEMKLS 1494 +LE+ A + A + + + +E+ A++++A E+ E +L+ Sbjct: 1660 ELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAE-ELA 1718 Query: 1495 QDQIGFQTFETVDVKFKEEFKPLSKEL-GEHGKEILLSNSDPHDIPESKDCVLTISEEMF 1553 G + + + L +EL E G +S+ +++ ++ E Sbjct: 1719 SSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERS 1778 Query: 1554 SKDKTFIVRQ-----------SIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQ 1602 + K RQ +H+ + E ++ + +++ ++ +E Q Sbjct: 1779 TAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQ 1838 Query: 1603 QATELLRQAHMR------QMERQREDQEQLQEE-------IKRLNRQLAQRSSIDNENLV 1649 AT+ L+Q + Q+E +R+ EQ +E+ +K+L RQL + + +++ + Sbjct: 1839 AATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQL-EEAEEESQRIN 1897 Query: 1650 SERERVLLEELEALKQLSLAGRE--KLCCELRNSSTQTQNGNENQG---EVEEQTFKEKE 1704 + R ++ E EA + GRE L +LR + + + G +E E+E Sbjct: 1898 ANRRKLQRELDEATESNEAMGREVNALKSKLRRGNETSFVPSRRSGGRRVIENADGSEEE 1957 Query: 1705 LDRKPED 1711 D + D Sbjct: 1958 TDTRDAD 1964 Score = 106 bits (265), Expect = 4e-22 Identities = 232/1242 (18%), Positives = 512/1242 (41%), Gaps = 173/1242 (13%) Query: 2124 KCSELLLSKEQLQRD----IQERNEEIEKLEFRVRELEQALLVEDRKHFGAVEAKPELSL 2179 K + L + + +QR+ ++ RN + +L +V+ L Q E+ E + Sbjct: 808 KRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKER 867 Query: 2180 EVQLQAERDAIDRKEKEITN----LEEQL----------EQFREELENKNEEVQQLHMQL 2225 + + + E +++K ++T L+EQL E+ R L K +E++++ ++ Sbjct: 868 QQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEM 927 Query: 2226 EIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVE 2285 E + +E R Q+L+ E K M L ++E +A + Q A+ I++ E E Sbjct: 928 EARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAK-IKKLEDE 986 Query: 2286 IDQLNEQVTKLQQQLK--------ITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNR 2337 I +++Q KL ++ K +TT+ EEK + + L+ + E ++S+ E V+ + Sbjct: 987 ILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELE-VRLKK 1045 Query: 2338 EEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETA 2397 E EK +QEL + +K +A E+ L+ Q+ + + E++++ A Sbjct: 1046 E----------EKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAA 1095 Query: 2398 ----NEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKD 2453 ++E+ N LK K+ +L + L+ + +S ++ E + L Sbjct: 1096 LARLDDEIAQKNNALK----KIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEAL 1151 Query: 2454 KPELEVVL----TEDALKSLENQ---TYFKSFEENGKGSIINLETRLLQLESTVSAKDLE 2506 K ELE L T+ L++ Q K+ +E + E ++ ++ + E Sbjct: 1152 KTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSH----EAQVQEMRQKHAQAVEE 1207 Query: 2507 LTQCYKQIKDMQEQGQFETEMLQKKIVNLQ---KIVEEKVAAALVSQIQLEA-VQEYAKF 2562 LT+ +Q K + + L+K+ +L +++ + + +LEA VQE Sbjct: 1208 LTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSK 1267 Query: 2563 CQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVE 2622 C D + +E LN + +L +++ ++T ++E E + +++ + Q++ Sbjct: 1268 CSDGERARAE--------LND-KVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQ 1318 Query: 2623 IAEKNVLEKEKKLLELQKLL-----EGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEE- 2676 ++ + E+ ++ L + L E N + + E+ + Q++E +T + S+ + Sbjct: 1319 DTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKK 1378 Query: 2677 --SGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAE 2734 F + +EAL + E+ + ++ E+ E LQ++L + L Sbjct: 1379 KLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDN 1438 Query: 2735 AKEKLSILEKE----DETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQIL 2790 ++ +S LEK+ D+ +E +S A + D + +T + Sbjct: 1439 QRQLVSNLEKKQRKFDQLLAEEK-----------NISSKYADERDRAEAEAREKETKALS 1487 Query: 2791 VKNAGIQINLQSECSSEEVTEIISQFTEKIEKMQELHAAEILDMES------RHISETET 2844 + A EE E E++E+ ++ AE+ D+ S +++ E E Sbjct: 1488 LARA-----------LEEALEA----KEELERTNKMLKAEMEDLVSSKDDVGKNVHELEK 1532 Query: 2845 LKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREICSSDSGSDWGQG 2904 KR ++ +K + L+ +Q A DA E+ + + GQ Sbjct: 1533 SKRALETQMEEMKTQLEELEDELQ-------------ATEDAKLRLEV---NMQALKGQ- 1575 Query: 2905 IYLTHSQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQ-VLSLTESPYSDGEDH 2963 F+ + R E++E +++ + +E Q L+ +G+ Sbjct: 1576 --------FERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLK 1627 Query: 2964 SIQQVSEPWLEERKAYINTISSLKDLITKMQLQRE------AEVYDSSQSHE-SFSDWRG 3016 ++ ++ ++ R+ I + L+ + Q + E E++ +++ +E Sbjct: 1628 DLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEA 1687 Query: 3017 ELLLALQQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQ----------RIQEQGVE 3066 +L+ + + ER+ A E A ++ N L+ +++E+ E Sbjct: 1688 DLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEE 1747 Query: 3067 YQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQML 3126 Q ME + R++ Q L E +E+ + + E QQ + Q Sbjct: 1748 EQGNMEAMSDRVRKATQQAEQ------------LSNELATERSTAQKNESARQQLERQNK 1795 Query: 3127 EMQVELSSMKDRA-TELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFR 3185 E++ +L M+ ++ + +++ + +A+L+ ++ Q E + K+ + K+L+ Sbjct: 1796 ELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEIL 1855 Query: 3186 LEVKDKTDEVHLLNDTLASEQKKSRELQWAL---EKEKAKLGRSEERDKEELEDLKFSLE 3242 L+V+D+ + + ++L+ L E+E ++ + + + EL++ S E Sbjct: 1856 LQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNE 1915 Query: 3243 SQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQ 3284 + + L L + + ++ +R++ +A SEE+ Sbjct: 1916 AMGREVNALKSKLRRGNETSFVPSRRSGGRRVIENADGSEEE 1957 Score = 82.8 bits (203), Expect = 6e-15 Identities = 170/823 (20%), Positives = 351/823 (42%), Gaps = 127/823 (15%) Query: 2923 ESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINT 2982 ++E+ + ++++ L A E ++L E+ + ED Q +E RK Sbjct: 897 QAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAE-----RKKMAQQ 951 Query: 2983 ISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELL--------LALQQVFLEERSVLL 3034 + L++ + + + R+ + + E+L L+ ++ LEER L Sbjct: 952 MLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDL 1011 Query: 3035 AAFRTE-------LTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQK--ADRRSLLSE 3085 E LT L +++ LE R++++ Q + +K D + Sbjct: 1012 TTNLAEEEEKAKNLTKLKNKHE-SMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQ 1070 Query: 3086 IQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQ 3145 I L AQ+ K+ L +++E + + L+ I QK + + +++ ++ ++LQE Sbjct: 1071 IADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIR----ELEGHISDLQED 1126 Query: 3146 LSSEKMV-------VAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLL 3198 L SE+ +L EL K ELE TL + +EL A R + EV +L Sbjct: 1127 LDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQ-QELRAKREQ------EVTVL 1179 Query: 3199 NDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLK---FSLESQKQRNLQLNLLL 3255 L E+ +S E Q +++ + K ++ E E+LE K +L+ KQ + N L Sbjct: 1180 KKAL-DEETRSHEAQ--VQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADL 1236 Query: 3256 EQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELH 3315 + ++L +++Q++E ++ +AQ+ E Q + + E+ R + D+ +L Sbjct: 1237 AGELRVLGQAKQEVEHKKKKLEAQVQELQSK------CSDGERAR----AELNDKVHKLQ 1286 Query: 3316 AQLQSSDGT---GQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQM 3372 +++S G + + ++D+ L QL++ ELL E + KL+ +Q+ Sbjct: 1287 NEVESVTGMLNEAEGKAIKLAKDVAS-LSSQLQDTQ----ELLQEETRQKLNVSTKLRQL 1341 Query: 3373 EKDRQVHRKTLQTEQEAN--------------TEGQKKMHE--------------LQSKV 3404 E++R + L E EA ++ +KK+ + Q ++ Sbjct: 1342 EEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEI 1401 Query: 3405 EDLQRQLEEKRQQVYKLDLEGQRLQGIMQEF------QKQELEREEKRESR--RILYQNL 3456 E+L +Q EEK KL+ RLQ + + Q+Q + EK++ + ++L + Sbjct: 1402 ENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEK 1461 Query: 3457 NEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELE----MIRQKLQ 3512 N + ++ DR + E ETK + A+ +E ELE M++ +++ Sbjct: 1462 NISSKYADERDRAE----AEAREKETKALSLARALE---EALEAKEELERTNKMLKAEME 1514 Query: 3513 CVASKLQVLPQKASERLQFETADDEDFIWVQENIDEIILQLQKLTGQ-QGEEPSLVSPST 3571 + S + + E + + A ++ ++E+ QL++L + Q E + + Sbjct: 1515 DLVSSKDDVGKNVHELEKSKRA-------LETQMEEMKTQLEELEDELQATEDAKLRLEV 1567 Query: 3572 SCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRFSLN 3631 + +L + R +L Q E++ L+ + + E ++ R+ A +++ L Sbjct: 1568 NMQALKGQFER---DLQARDEQNEEKRRQLQRQLHEYETELEDERKQRA-LAAAAKKKLE 1623 Query: 3632 GGANIEAIIASEKEVWNREKLTLQKSLKRAEAEVYKLKAELRN 3674 G + + ++ + RE+ K L++ +A++ + EL + Sbjct: 1624 GDLK-DLELQADSAIKGREEAI--KQLRKLQAQMKDFQRELED 1663 Score = 76.3 bits (186), Expect = 6e-13 Identities = 119/577 (20%), Positives = 241/577 (41%), Gaps = 64/577 (11%) Query: 3153 VAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQK---KS 3209 V + E+ + EL+ T + Q K EL+ + T+E +LL + L +E + ++ Sbjct: 847 VTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEA 906 Query: 3210 RELQWALEKEKAKLGR---SEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQ 3266 E++ L +K +L E EE ED L++++++ Q L LE+Q + ++ Sbjct: 907 EEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAAR 966 Query: 3267 QKIESQRMLYDAQLS---------EEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQ 3317 QK++ +++ +A++ ++Q L + L E RI ++++ L E E Sbjct: 967 QKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEE--RISDLTTNLAEEEEKAKN 1024 Query: 3318 LQSSDGTGQS---------RPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQT 3368 L +S + S L++L+++LE S E + + + + Sbjct: 1025 LTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQ 1084 Query: 3369 RQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLE---- 3424 + E++ Q L E KK+ EL+ + DLQ L+ +R K + + Sbjct: 1085 LAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDL 1144 Query: 3425 GQRLQGIMQEFQ--------KQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQ 3476 G+ L+ + E + +QEL R ++ + +L + L+E T + Q Sbjct: 1145 GEELEALKTELEDTLDSTATQQEL-RAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQ 1203 Query: 3477 KIEGETKESNYAKLIEMN---------GGGTGCNHELEMIRQKLQCVASKLQVLPQKASE 3527 +E T++ K + N EL ++ Q Q V K + L + E Sbjct: 1204 AVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQE 1263 Query: 3528 RLQFETADDEDF-IWVQENIDEIILQLQKLTGQQGE-EPSLVSPSTSCGSLTERL----- 3580 LQ + +D E + + + ++ +++ +TG E E + + SL+ +L Sbjct: 1264 -LQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQE 1322 Query: 3581 -----LRQNAELTGHISQLTEEKNDLRNMV---MKLEEQIRWYRQTGAGRDNSSRFSLNG 3632 RQ ++ + QL EE+N L++ + M+ ++ + + T + + S+ L Sbjct: 1323 LLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQD 1382 Query: 3633 GANIEAIIASEKEVWNREKLTLQKSLKRAEAEVYKLK 3669 A+ + K+ + +E L + + A KL+ Sbjct: 1383 FASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLE 1419 Score = 71.6 bits (174), Expect = 1e-11 Identities = 92/466 (19%), Positives = 200/466 (42%), Gaps = 52/466 (11%) Query: 3173 AQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKE 3232 A + L+ + +RL K K LL T E+ +++E + KE+ + +E ++ E Sbjct: 824 AAYLKLRNWQWWRLFTKVKP----LLQVTRQEEEMQAKEDELQKTKERQQKAENELKELE 879 Query: 3233 E----LEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNL 3288 + L + K L+ Q Q +L E+ + L +Q++E +A+L EE+ R Sbjct: 880 QKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQ 939 Query: 3289 ELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDL---------LKE 3339 +LQ + ++ ++ L+ E +LQ T +++ +++ L + Sbjct: 940 QLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSK 999 Query: 3340 LQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHE 3399 +K LEE+ S + L E E+ + + + + E L+ E+++ E +K + Sbjct: 1000 ERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRK 1059 Query: 3400 LQSKVEDLQRQLEEKRQQVYKLDLE----GQRLQGIMQEFQKQELEREEKRESRRILYQN 3455 L+ D Q+ + + Q+ +L ++ + LQ + + ++ + R L + Sbjct: 1060 LEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGH 1119 Query: 3456 LNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMIRQKLQ--- 3512 +++ LQ+ ++ E N A+ + + G ELE ++ +L+ Sbjct: 1120 ISD---------------LQEDLDSERAARNKAEKQKRDLG-----EELEALKTELEDTL 1159 Query: 3513 -CVASKLQVLPQKASERLQFETADDEDF----IWVQENIDEIILQLQKLTGQQGEEPSLV 3567 A++ ++ ++ E + A DE+ VQE + +++LT Q + Sbjct: 1160 DSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQ---FK 1216 Query: 3568 SPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKLEEQIR 3613 + + L ++NA+L G + L + K ++ + KLE Q++ Sbjct: 1217 RAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQ 1262 Score = 70.5 bits (171), Expect = 3e-11 Identities = 90/425 (21%), Positives = 184/425 (43%), Gaps = 61/425 (14%) Query: 169 HEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQ----------QAR 218 HE+E+ R LE T E QL+E E ++ + +L N+Q QAR Sbjct: 1528 HELEKSKRALE----TQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQAR 1583 Query: 219 REKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADL----LQAKQQILTHQ 274 E++E R +L Q + + + + + L + DL LQA I + Sbjct: 1584 DEQNEEKRR--QLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGRE 1641 Query: 275 Q---QLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETII 331 + QL + ++D+Q++ ED +++I E +KK ++ + +Q +E + Sbjct: 1642 EAIKQLRKLQAQMKDFQRELEDARAS----RDEIFATAKENEKKAKSLEADLMQLQEDLA 1697 Query: 332 EELNTKI---IEEEKKTLELKDKLTTADKLLGE---LQEQIVQKNQEIKNMKLELTNSKQ 385 + +E+E+ EL L+ + L E L+ +I Q +E++ + + Sbjct: 1698 AAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSD 1757 Query: 386 KERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQI 445 + R+++++ +QL + + K+ + Q+ +R+ ++LR++L EM G Sbjct: 1758 RVRKATQQAEQLSNELATERSTAQKN--------ESARQQLERQNKELRSKLHEMEGAVK 1809 Query: 446 VQMKQEL--IRQHMAQMEEMKTRHKGEMENALRSYSN--------ITVNEDQIKLMNVAI 495 + K + + +AQ+EE + E + A +S + ED+ K+ Sbjct: 1810 SKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYK 1869 Query: 496 NEL---NIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVE-------ELSFSREQIQ 545 + N +++ Q E+ +EE I + LQR+L++ E E++ + +++ Sbjct: 1870 EQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLR 1929 Query: 546 RARQT 550 R +T Sbjct: 1930 RGNET 1934 Score = 58.5 bits (140), Expect = 1e-07 Identities = 91/505 (18%), Positives = 214/505 (42%), Gaps = 75/505 (14%) Query: 4 EERQKKLEAGKAKLAQFRQRKAQSDGQSPSKKQKKKRKTSSSKHDVSAHHDLNIDQSQCN 63 E++Q+K + A+ + A ++ ++ ++K+ K S + + + + N Sbjct: 1447 EKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTN 1506 Query: 64 EMYINSSQRVESTVIPESTIMRTLHSGEITSHEQGFSVELESEISTTADDCSSEVNGCSF 123 +M +E V + + + +H E+ ++ ++E E+ T ++ E+ Sbjct: 1507 KML---KAEMEDLVSSKDDVGKNVH--ELEKSKRALETQME-EMKTQLEELEDELQATED 1560 Query: 124 V-MRTGKPTNLLR---EEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHEI-------E 172 +R L+ E + D +E+ + L E+EL ++ + + Sbjct: 1561 AKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKK 1620 Query: 173 ELNRELEEMRVTYGT------EGLQQLQEFEAAIKQ-----------RDGIITQLTANLQ 215 +L +L+++ + + E ++QL++ +A +K RD I N + Sbjct: 1621 KLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEK 1680 Query: 216 QARREKDETMR--EFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAA--DLLQAKQQIL 271 +A+ + + M+ E L E+++K Q ++ + +E L +S A + + + +I Sbjct: 1681 KAKSLEADLMQLQEDLAAAERARK-QADLEKEELAEELASSLSGRNALQDEKRRLEARIA 1739 Query: 272 THQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETII 331 +++LEE+ +E + T Q L E+ ++ N+ Q+ E Sbjct: 1740 QLEEELEEEQGNMEAMSDRVRKATQQAEQLSN-----ELATERSTAQKNESARQQLERQN 1794 Query: 332 EELNTKIIEEEKKTL-ELKDKLTTADKLLGELQEQIVQ--------------KNQEIKNM 376 +EL +K+ E E + K + + + +L+EQ+ Q K++++K + Sbjct: 1795 KELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEI 1854 Query: 377 KLELTNSKQKERQSSEE-------IKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRK 429 L++ + ++ Q E+ +KQL +EE ++ E+ + ++ QR+ Sbjct: 1855 LLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEE--------ESQRINANRRKLQRE 1906 Query: 430 LEQLRAELDEMYGQQIVQMKQELIR 454 L++ E +E G+++ +K +L R Sbjct: 1907 LDE-ATESNEAMGREVNALKSKLRR 1930 >gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo sapiens] Length = 1979 Score = 157 bits (396), Expect = 3e-37 Identities = 224/1105 (20%), Positives = 486/1105 (43%), Gaps = 167/1105 (15%) Query: 157 LEMMESELAGKQHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQ 216 ++ E EL + ++ EL+E+ + QL E + ++++ T+L A ++ Sbjct: 861 MQAKEDELQKTKERQQKAENELKELEQKHS-----QLTEEKNLLQEQLQAETELYAEAEE 915 Query: 217 ARREKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQ 276 R + L + Q+L+ +++A A+ + QQ+L ++Q Sbjct: 916 MR----------VRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQ 965 Query: 277 LEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYE------------------------MEQ 312 LEE++ + Q +K +I L+++I V + E+ Sbjct: 966 LEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEE 1025 Query: 313 DKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELK--------------DKLTTADKL 358 ++K +N K + + E++I EL ++ +EEK EL+ +++ Sbjct: 1026 EEKAKNLTKLK-NKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQ 1084 Query: 359 LGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDI 418 + EL+ Q+ +K +E++ L + ++ + ++I++L G + +LQ+ + + + Sbjct: 1085 IAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQE-DLDSERAARNK 1143 Query: 419 VQRMEQETQRKLEQLRAELDEMYG-------------QQIVQMKQEL---IRQHMAQMEE 462 ++ +++ +LE L+ EL++ Q++ +K+ L R H AQ++E Sbjct: 1144 AEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQE 1203 Query: 463 MKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEE 522 M+ +H +E +T +Q K +++ L+ N+ LG +E Sbjct: 1204 MRQKHAQAVE-------ELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQE 1256 Query: 523 KCALQRQLEDLVEELSFSREQIQRARQTIAEQESK-----------LNEAH-KSLSTVED 570 +++LE V+EL +RAR + ++ K LNEA K++ +D Sbjct: 1257 VEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKD 1316 Query: 571 LKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAE--LER---- 624 + A + S + +EL + + N KL LE+E+N++ D++ E EA+ LER Sbjct: 1317 V-ASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHIST 1375 Query: 625 LRTQLLFSHE--EELSKLKEDLEIEHRINIEKLKDNLGIHYKQ------QIDGLQNEMSQ 676 L QL S + ++ + E LE E + +K +NL Y++ +++ +N + Q Sbjct: 1376 LNIQLSDSKKKLQDFASTVEALE-EGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQ 1434 Query: 677 KIETMQFEKDNLITKQNQLILEI-SKLKDLQQSLVNSKS-------EEMTLQINELQKEI 728 +++ + + DN Q QL+ + K + Q L K+ E + +KE Sbjct: 1435 ELDDLVVDLDN----QRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKET 1490 Query: 729 EILRQEEKEKGTLEQEVQELQLKTELLEKQMKE---KENDLQEKFAQLEAENSILK---D 782 + L + LE + +EL+ ++L+ +M++ ++D+ + +LE L+ + Sbjct: 1491 KALSLARALEEALEAK-EELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQME 1549 Query: 783 EKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENED----LKQQCIQ 838 E KT + L+ +++ +L + ++ +E++++ E+NE+ L++Q + Sbjct: 1550 EMKTQLEELEDELQATEDAKLRL--EVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHE 1607 Query: 839 LNEEIE---KQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKA 895 E+E KQR + A+K E + ++L+ + +K +++ KQ + ++++K Sbjct: 1608 YETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREE----AIKQLRKLQAQMKD 1663 Query: 896 LNEELHLQRINPTTV-------KMKSSVFDEDKTFVAETLEMGEVVEK----DTTELMEK 944 EL R + + + K+ + D + E L E K + EL E+ Sbjct: 1664 FQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEE 1723 Query: 945 L-------EVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCREL 997 L + EK L R++ L E+L+++ G + +++ V+ Q+ EQ+S Sbjct: 1724 LASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLS-----N 1778 Query: 998 EIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFE 1057 E+ + A+ +S Q+ + + EG+V KS + + +E K++ Sbjct: 1779 ELATERSTAQKNESARQQLER-QNKELRSKLHEMEGAV----KSKFKSTIAALEAKIAQL 1833 Query: 1058 NMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQR 1117 V +E++++Q L K+ Q + K+ ++ ++E+ + R++ ++ Sbjct: 1834 EEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKE-QAEKGNARVKQLKRQ 1892 Query: 1118 ICLSLVYSTHVDQVREYMENEKDKA 1142 + + S ++ R ++ E D+A Sbjct: 1893 LEEAEEESQRINANRRKLQRELDEA 1917 Score = 154 bits (389), Expect = 2e-36 Identities = 229/1044 (21%), Positives = 454/1044 (43%), Gaps = 145/1044 (13%) Query: 1935 ERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEA---MKAEAGPVE 1991 E ++Q K D + + ++ A N L+ELE + Q+ EE+ LL Q +A + AEA + Sbjct: 858 EEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMR 917 Query: 1992 QQLL---QETEKLMKEKLEVQCQAEKVR-DDLQKQVKALE---IDVEEQVSRFIELEQEK 2044 +L QE E+++ E +E + + E+ R LQ + K + +D+EEQ +E E+ Sbjct: 918 VRLAAKKQELEEILHE-MEARLEEEEDRGQQLQAERKKMAQQMLDLEEQ----LEEEEAA 972 Query: 2045 NTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKL-----EQQLKVVPR 2099 +L + +A K+LE +D+Q ER + ++ I L E++ K Sbjct: 973 RQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNL 1032 Query: 2100 FQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQA 2159 + ++H++ + +L LK++ EL K +L+ D + +E+I L+ ++ EL+ Sbjct: 1033 TKLKNKHESM-ISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQ 1091 Query: 2160 LLVEDRKHFGAV------------------EAKPELS-LEVQLQAERDAIDRKEKEITNL 2200 L ++ + A+ E + +S L+ L +ER A ++ EK+ +L Sbjct: 1092 LAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDL 1151 Query: 2201 EEQLEQFREELEN--------------KNEEVQQLHMQLEIQKKESTTRLQELEQEN--- 2243 E+LE + ELE+ + +EV L L+ + + ++QE+ Q++ Sbjct: 1152 GEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQA 1211 Query: 2244 -----------KLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQ 2292 K K +++K +++ +A + VL Q QE E + +L Q Sbjct: 1212 VEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVL----GQAKQEVEHKKKKLEAQ 1267 Query: 2293 VTKLQQQLKITTDNKVIEEKNELIRDLETQIEC---LMSDQECVKRNREEEIEQLNEVI- 2348 V +LQ K + + E N+ + L+ ++E ++++ E +++ L+ + Sbjct: 1268 VQELQS--KCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQ 1325 Query: 2349 --EKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKN 2406 ++L QE S L EE +SL+ QLD + K LE+ + T N +++ K Sbjct: 1326 DTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKK 1385 Query: 2407 VLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDAL 2466 L++ + L + KR ++ +E + E A D L K K L+ L +D + Sbjct: 1386 KLQDFASTVEALEE---GKKRFQKEIENLTQQYEEKA-AAYDKLEKTKNRLQQEL-DDLV 1440 Query: 2467 KSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETE 2526 L+NQ S E + +LL E +S+K D +++ + E Sbjct: 1441 VDLDNQRQLVSNLEKKQRKF----DQLLAEEKNISSK----------YADERDRAEAEAR 1486 Query: 2527 MLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLRE 2586 + K ++L + +EE AL ++ +LE + K ++ S + N+ L + + Sbjct: 1487 EKETKALSLARALEE----ALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKR 1542 Query: 2587 ------DELGSDISALTLRISELESQVVEMHTSLILEKEQVE-IAEKNVLEKEKKLLELQ 2639 +E+ + + L + E + + ++ K Q E + + E+K +LQ Sbjct: 1543 ALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQ 1602 Query: 2640 KLLE------GNEKKQR---EKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAES 2690 + L +E+KQR KK+ D++ L+ + E +L L+A+ Sbjct: 1603 RQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEA-IKQLRKLQAQM 1661 Query: 2691 VATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAK--EKLSILEKEDET 2748 + EL + +++ E SL+ DL Q+++ LA A+ K + LEKE+ Sbjct: 1662 KDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEE-- 1719 Query: 2749 EVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSS-E 2807 L++ +AS G + + ++ ++ + A ++ L+ E + E Sbjct: 1720 -----------------LAEELASSLSG--RNALQDEKRRLEARIAQLEEELEEEQGNME 1760 Query: 2808 EVTEIISQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVI 2867 +++ + + T++ E++ A E ++ S + L+R++ L E G +K+ Sbjct: 1761 AMSDRVRKATQQAEQLSNELATE-RSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKF 1819 Query: 2868 QCLRSKEGSSIPELAHSDAYQTRE 2891 + + + I +L + RE Sbjct: 1820 KSTIAALEAKIAQLEEQVEQEARE 1843 Score = 154 bits (388), Expect = 2e-36 Identities = 232/1212 (19%), Positives = 531/1212 (43%), Gaps = 166/1212 (13%) Query: 225 MREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLL 284 ++ L++T Q +++Q + +LQ ++ + + +L + +Q+ QL E+ +LL Sbjct: 848 VKPLLQVTRQEEEMQAKEDELQKTKERQQKAEN----ELKELEQK----HSQLTEEKNLL 899 Query: 285 EDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKK 344 ++ LQ + ++Y ++ +V + K+ QE E I+ E+ ++ EEE + Sbjct: 900 QEQ-------------LQAETELYAEAEEMRVRLAAKK--QELEEILHEMEARLEEEEDR 944 Query: 345 TLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEEL 404 +L+ + + + +L+EQ+ ++ + ++LE ++ K ++ +EI + +L Sbjct: 945 GQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKL 1004 Query: 405 QKRNHKDSQFETDIVQRM--EQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEE 462 K + +D+ + E+E + L +L+ + + M + V++K+E + ++E+ Sbjct: 1005 SKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKE--EKSRQELEK 1062 Query: 463 MKTRHKGEMENALRSYSNITVNEDQIKL--------MNVAINELNIKLQDTNSQKEKLKE 514 +K + +G+ + +++ ++K+ + A+ L+ ++ N+ +K++E Sbjct: 1063 LKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRE 1122 Query: 515 ELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAE 574 L+ + DL E+L R AR +Q+ L E ++L T + + Sbjct: 1123 -----------LEGHISDLQEDLDSER----AARNKAEKQKRDLGEELEALKTELE---D 1164 Query: 575 IVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHE 634 + ++ +++EL K E EVT K LD S EA+++ +R + H Sbjct: 1165 TLDSTATQQELRAKREQEVTVLK-----------KALDEETRSHEAQVQEMRQK----HA 1209 Query: 635 EELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQ 694 + + +L E LE ++ K NL + KQ ++ +++ ++ + K + K+ + Sbjct: 1210 QAVEELTEQLE-----QFKRAKANLDKN-KQTLEKENADLAGELRVLGQAKQEVEHKKKK 1263 Query: 695 LILEISKLKDLQQSLVNSKSEEMTLQINELQKEIE----ILRQEEKEKGTLEQEV----Q 746 L ++ +L+ +++ E+ ++++LQ E+E +L + E + L ++V Sbjct: 1264 LEAQVQELQSKCSDGERARA-ELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSS 1322 Query: 747 ELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFL 806 +LQ ELL+++ ++K N + K QLE E + L+D+ L++ ++ + + + + Sbjct: 1323 QLQDTQELLQEETRQKLN-VSTKLRQLEEERNSLQDQ---LDEEMEAKQNLERHISTLNI 1378 Query: 807 DSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQE 866 SK K + +E L E +K F+ + L + Sbjct: 1379 QLSDSKKKLQDFASTVEALEE-------------------------GKKRFQKEIENLTQ 1413 Query: 867 EYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAE 926 +Y D LE +KN+ + E L L +L QR + ++ K FD+ +AE Sbjct: 1414 QYEEKAAAYDKLEKTKNRLQQE----LDDLVVDLDNQRQLVSNLEKKQRKFDQ---LLAE 1466 Query: 927 TLEMGE--VVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLK 984 + E+D E + + TK L L++ L + E ++ L E++ L Sbjct: 1467 EKNISSKYADERDRAEAEAREKETK--ALSLARALEEALEAKEELERTNKMLKAEMEDLV 1524 Query: 985 QEKEQVSLRCRELEIIINHNRA--ENVQSCDTQVSSLLDGV---------VTMTSRGAEG 1033 K+ V ELE RA ++ TQ+ L D + + + + +G Sbjct: 1525 SSKDDVGKNVHELE---KSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKG 1581 Query: 1034 SVSK---VNKSFGEESKIMVEDKVSFENMTVGEESKQEQLIL---DHLPSVTKESSLRAT 1087 + EE + ++ ++ + +E KQ L L K+ L+A Sbjct: 1582 QFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQAD 1641 Query: 1088 QPSE-NDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSL 1146 + ++ K+L L+++ D + ++E R +++T + ++ E D L L Sbjct: 1642 SAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEAD--LMQL 1699 Query: 1147 KEELIFAQE-EKIKELQK---IHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYF 1202 +E+L A+ K +L+K +L DE + L I +L++ + EE Sbjct: 1700 QEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEE---- 1755 Query: 1203 LQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLLNK 1262 Q + + A + ++ + ++ + Q + ++ + +H + Sbjct: 1756 -QGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGA 1814 Query: 1263 VTEEY-NKLLVLQTRLSKIWGQ-QTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVN 1320 V ++ + + L+ +++++ Q + + + + ++L +++ + I Q+ + + Sbjct: 1815 VKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQ 1874 Query: 1321 HKSKL----SSLQDLEK--TKLEEQVQELESLISSLQQQLKETEQNYEA---EIHCLQKR 1371 +K + + ++ L++ + EE+ Q + + LQ++L E ++ EA E++ L+ + Sbjct: 1875 YKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSK 1934 Query: 1372 LQAVSESTVPPS 1383 L+ +E++ PS Sbjct: 1935 LRRGNETSFVPS 1946 Score = 150 bits (380), Expect = 2e-35 Identities = 227/1071 (21%), Positives = 462/1071 (43%), Gaps = 156/1071 (14%) Query: 1563 QSIHDEISV---SSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLR--QAHMRQME 1617 + + DEI V + S++ L EE++ D+ L + ++ + T+L ++ + ++E Sbjct: 988 KKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELE 1047 Query: 1618 RQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCE 1677 + + +E+ ++E+++L R+L +S +E + L ++ LK E+L Sbjct: 1048 VRLKKEEKSRQELEKLKRKLEGDASDFHEQIAD-----LQAQIAELKMQLAKKEEELQAA 1102 Query: 1678 LRNSSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLE 1737 L + N ++ +EL+ D+ E L +ER A KA + + E Sbjct: 1103 LARLDDEIAQKNNALKKI-------RELEGHISDLQ-EDLDSERAARNKAEKQKRDLGEE 1154 Query: 1738 VVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPS 1797 + +E+T LD ++ Q + + E E +V +E TR + + Sbjct: 1155 LEALKTELEDT--------LDSTATQQELRA---KREQEVTVLKKALDEETRSHEAQVQE 1203 Query: 1798 YSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKL 1857 M K + EL+++L + A +D + L + A + Sbjct: 1204 ------------MRQKHAQAVEELTEQLEQFKRAKANLDKNKQTL-----EKENADLAGE 1246 Query: 1858 LEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVEL 1917 L + + ++EH K ++E + + ++ + + EL +++H+ E + L Sbjct: 1247 LRVLGQAKQEVEHKKKKLEAQVQEL---QSKCSDGERARAELNDKVHKLQNEVESVTGML 1303 Query: 1918 SKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLS 1977 ++AEG A + Q+Q+ +++ ++ L S +L++LE E+ +Q++ + Sbjct: 1304 NEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEM 1363 Query: 1978 RQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRF 2037 K+ ++ + QL +KL V+ E+ + QK+++ L EE+ + + Sbjct: 1364 EAKQNLERHISTLNIQLSDSKKKLQDFASTVEA-LEEGKKRFQKEIENLTQQYEEKAAAY 1422 Query: 2038 IELEQEKN-------TELMDLRQQNQALEKQLEKMRKF----LDEQAIDREH--ERDVFQ 2084 +LE+ KN ++DL Q Q + +K RKF +E+ I ++ ERD + Sbjct: 1423 DKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAE 1482 Query: 2085 QEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNE 2144 E ++ E + + R + E+E+ LK + + +L+ SK+ + +++ E + Sbjct: 1483 AEAREKETKALSLARALEEALEAKEELERTNKMLKAEME---DLVSSKDDVGKNVHELEK 1539 Query: 2145 EIEKLEFRVRELEQALLVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQL 2204 LE ++ E++ L LE +LQA DA R E N++ Sbjct: 1540 SKRALETQMEEMKTQL----------------EELEDELQATEDAKLRLE---VNMQALK 1580 Query: 2205 EQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMS 2264 QF +L+ ++E+ ++ QL+ Q E T L++ ++ L +KL +K+ + Sbjct: 1581 GQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKD---LE 1637 Query: 2265 TQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNK-----VIEEKNELIRDL 2319 Q + G+ +E ++ +L Q+ Q++L+ ++ +E + + L Sbjct: 1638 LQADSAIKGR-----EEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSL 1692 Query: 2320 ETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQ 2379 E + L D +R R++ + E+ E+L L+ ++L +E K + Sbjct: 1693 EADLMQLQEDLAAAERARKQADLEKEELAEELASSLS--------GRNALQDE----KRR 1740 Query: 2380 LDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIP 2439 L+ IA+ LE+++E M M + +++ + QL+ EL + ER + +K +S Sbjct: 1741 LEARIAQ---LEEELEEEQGNMEAMSDRVRKATQQAEQLSNELAT---ERSTAQKNES-- 1792 Query: 2440 ENSVNVAIDHLSKDKPELEVVL--TEDALKSLENQTYFKSFEENGKGSIINLETRLLQLE 2497 A L + EL L E A+KS K +I LE ++ QLE Sbjct: 1793 ------ARQQLERQNKELRSKLHEMEGAVKS------------KFKSTIAALEAKIAQLE 1834 Query: 2498 STVSAKDLELTQCYKQIKDMQEQGQFETEMLQ----KKIVNLQKIVEEKVAAALVSQI-- 2551 V + E K +K Q+ + + +LQ +K+ K EK A V Q+ Sbjct: 1835 EQVEQEAREKQAATKSLK--QKDKKLKEILLQVEDERKMAEQYKEQAEK-GNARVKQLKR 1891 Query: 2552 QLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLRE--DELGSDISALTLRI 2600 QLE +E ++Q I++ + + L++ E + +G +++AL ++ Sbjct: 1892 QLEEAEE------ESQRINANRRKLQ-RELDEATESNEAMGREVNALKSKL 1935 Score = 143 bits (360), Expect = 4e-33 Identities = 248/1144 (21%), Positives = 503/1144 (43%), Gaps = 154/1144 (13%) Query: 2386 EKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNV 2445 E A E +++ E +N LKE K +QLT+E L+ + ++ ++ + E + V Sbjct: 860 EMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEE-MRV 918 Query: 2446 AIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKG---SIINLETRLLQLESTVSA 2502 L+ K ELE +L E + E + + + K +++LE +L + E+ Sbjct: 919 ---RLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQK 975 Query: 2503 KDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEA-VQEYAK 2561 LE +IK ++++ + K+ +K++EE+++ + + E + K Sbjct: 976 LQLEKVTAEAKIKKLEDEILVMDDQ-NNKLSKERKLLEERISDLTTNLAEEEEKAKNLTK 1034 Query: 2562 FCQDNQTISSE------PERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLI 2615 ++++ SE E + Q L +L+ +L D S +I++L++Q+ E+ L Sbjct: 1035 LKNKHESMISELEVRLKKEEKSRQELEKLKR-KLEGDASDFHEQIADLQAQIAELKMQLA 1093 Query: 2616 LEKEQV---------EIAEKN-----VLEKEKKLLELQKLLEGNE--KKQREKEKKRSPQ 2659 ++E++ EIA+KN + E E + +LQ+ L+ + + EK+K+ + Sbjct: 1094 KKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGE 1153 Query: 2660 DVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMT 2719 ++E LKT ELE +S AT+ EL + +E+ + ++ L +ET Sbjct: 1154 ELEALKT---------------ELEDT-LDSTATQQELRAKREQEVTVLKKALDEETR-- 1195 Query: 2720 SLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKA-CMFEPLPIKLSKSIASQTDGTL 2778 S + + ++R A+A E+L+ ++++ K+A + L K A Sbjct: 1196 SHEAQVQEMRQKHAQAVEELT-------EQLEQFKRAKANLDKNKQTLEKENADLAGELR 1248 Query: 2779 KISSSNQTPQILVKNAGIQIN-LQSECSSEEVTEIISQFTEKIEKMQ---ELHAAEILDM 2834 + + Q + K Q+ LQS+CS E ++ +K+ K+Q E + + Sbjct: 1249 VLGQAKQEVEHKKKKLEAQVQELQSKCSDGERAR--AELNDKVHKLQNEVESVTGMLNEA 1306 Query: 2835 ESRHIS---ETETLKREHYVAVQLLKEECGTLKAVIQCLRS--KEGSSIPELAHSDAYQT 2889 E + I + +L + +LL+EE V LR +E +S+ + + Sbjct: 1307 EGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAK 1366 Query: 2890 REICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESESATDSFPKKIKGLLR------AVH 2943 + + S + I L+ S+ E E F K+I+ L + A + Sbjct: 1367 QNLERHISTLN----IQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAY 1422 Query: 2944 NEGMQVLSLTESPYSD---GEDHSIQQVSEPWLEERKAYINTISSLKDLITKMQLQR--- 2997 ++ + + + D D+ Q VS ++RK + ++ K++ +K +R Sbjct: 1423 DKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRK-FDQLLAEEKNISSKYADERDRA 1481 Query: 2998 EAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTALGTTDAVGL----- 3052 EAE + S + E L A ++ LE + +L A +L + + D VG Sbjct: 1482 EAEAREKETKALSLARALEEALEAKEE--LERTNKMLKAEMEDLVS--SKDDVGKNVHEL 1537 Query: 3053 ---LNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEI--QALHAQMNGRKITLKREQESE 3107 LE +++E + + + LQ + L E+ QAL Q R + + EQ E Sbjct: 1538 EKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFE-RDLQARDEQNEE 1596 Query: 3108 KPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLEL 3167 K +Q Q Q+ E + EL + +Q + +L+ +L +L+ Sbjct: 1597 KR---------RQLQRQLHEYETELEDER-------KQRALAAAAKKKLEGDLKDLELQA 1640 Query: 3168 ETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSE 3227 ++ +K + + +K+L + ++KD E+ + + SR+ +A KE K +S Sbjct: 1641 DSAIKGREEAIKQLRKLQAQMKDFQRELE--------DARASRDEIFATAKENEKKAKSL 1692 Query: 3228 ERDKEEL-EDLKFSLESQKQRNLQLNLLLEQQ------KQLLNESQQKIESQRMLYDAQL 3280 E D +L EDL + ++KQ +L+ L E+ + L + ++++E++ + +L Sbjct: 1693 EADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEEL 1752 Query: 3281 SEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKEL 3340 EEQG +E+ R+R+ + + +L +L + T Q +E ++L Sbjct: 1753 EEEQGN-------MEAMSDRVRKATQQAE---QLSNELATERSTAQK-----NESARQQL 1797 Query: 3341 QKQLEEKHSRIVELLNETE---KYKLDSLQTR-QQMEKDRQVHRKTLQTEQEANTEGQKK 3396 ++Q +E S++ E+ + K + +L+ + Q+E+ + + Q ++ + KK Sbjct: 1798 ERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKK 1857 Query: 3397 MHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELEREEKRESRRILYQNL 3456 + E+ +VED ++ E+ ++Q K R++ + ++ ++ E E + +RR L + L Sbjct: 1858 LKEILLQVEDERKMAEQYKEQAEK---GNARVKQLKRQLEEAEEESQRINANRRKLQREL 1914 Query: 3457 NEPT 3460 +E T Sbjct: 1915 DEAT 1918 Score = 135 bits (339), Expect = 1e-30 Identities = 239/1142 (20%), Positives = 497/1142 (43%), Gaps = 115/1142 (10%) Query: 1976 LSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVS 2035 ++RQ+E M+A+ E +L + E+ K + E++ + E+ L ++ L+ ++ + Sbjct: 854 VTRQEEEMQAK----EDELQKTKERQQKAENELK-ELEQKHSQLTEEKNLLQEQLQAETE 908 Query: 2036 RFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDR----EHERDVFQQEIQKLE 2091 + E E+ + + L + Q LE+ L +M L+E+ DR + ER Q++ LE Sbjct: 909 LYAEAEEMR----VRLAAKKQELEEILHEMEARLEEEE-DRGQQLQAERKKMAQQMLDLE 963 Query: 2092 QQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEF 2151 +QL+ + + Q ++E++ K K + E+L+ +Q + +ER + LE Sbjct: 964 EQLE-----EEEAARQKLQLEKVTAEAKIKKLE-DEILVMDDQNNKLSKER----KLLEE 1013 Query: 2152 RVRELEQALLVEDRKHFGAVEAKPE-----LSLEVQLQAERDAIDRKEKEITNLEEQLEQ 2206 R+ +L L E+ K + K + LEV+L+ E + EK LE Sbjct: 1014 RISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASD 1073 Query: 2207 FREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQ 2266 F E++ + ++ +L MQL +++E L L+ E + ++K I+E + + Sbjct: 1074 FHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKK----IRELEGHISD 1129 Query: 2267 DQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECL 2326 Q L + A + ++ + D L E++ L+ +L+ T D+ +++ R+ E + Sbjct: 1130 LQEDLDSERAARNKAEKQKRD-LGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKK 1188 Query: 2327 MSDQEC---------VKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLK 2377 D+E +++ + +E+L E +E+ ++ AN+ + N +L +E L Sbjct: 1189 ALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDK----NKQTLEKENADLA 1244 Query: 2378 HQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQS 2437 +L V+ K +E + + ++ +++ + +L ++ L+ E ESV + + Sbjct: 1245 GELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLN 1304 Query: 2438 IPE-NSVNVAID--HLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRL- 2493 E ++ +A D LS + + +L E+ + L T + EE L+ + Sbjct: 1305 EAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEME 1364 Query: 2494 --LQLESTVSAKDLELTQCYKQIKDMQ------EQGQFETEMLQKKIVNLQKIVEEKVAA 2545 LE +S +++L+ K+++D E+G+ + QK+I NL + EEK AA Sbjct: 1365 AKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGK---KRFQKEIENLTQQYEEKAAA 1421 Query: 2546 ALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELES 2605 +LE + + D+ + + +R + NL + + + +L + Sbjct: 1422 ----YDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQR------------KFDQLLA 1465 Query: 2606 QVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLK 2665 + + + E+++ AE EKE K L L + LE + + E E+ E+ Sbjct: 1466 EEKNISSKYADERDR---AEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEM-- 1520 Query: 2666 TTTELFHSNEESG-FFNELE----ALRAESVATKAELASYKEKAEKLQEELLVKETNMTS 2720 +L S ++ G +ELE AL + K +L +++ + ++ L E NM + Sbjct: 1521 --EDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQA 1578 Query: 2721 L----QKDLSQVRDHLAEAKEKLSILEKEDETEVQ-ESKKACMFEPLPIKLS---KSIAS 2772 L ++DL + E + +L E ETE++ E K+ + KL K + Sbjct: 1579 LKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLEL 1638 Query: 2773 QTDGTLK--ISSSNQTPQILVKNAGIQINLQSECSSEEVTEIISQFTEKIEKMQELHAAE 2830 Q D +K + Q ++ + Q L+ +S + EI + E +K + L A+ Sbjct: 1639 QADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRD--EIFATAKENEKKAKSLE-AD 1695 Query: 2831 ILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTR 2890 ++ ++ ++ E +++ + + L EE + + L+ ++ +A + Sbjct: 1696 LMQLQ-EDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEE 1754 Query: 2891 EICSSDSGSD-WGQGIYLTHSQGFDIASE-GRGEESESATDSFPKKIKGLLRAVHNEGMQ 2948 E + ++ SD + ++A+E +++ESA ++ K L +H Sbjct: 1755 EQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGA 1814 Query: 2949 VLSLTESPYS--DGEDHSIQQVSEPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQ 3006 V S +S + + + +++ E E++A ++ + ++ LQ E E + Q Sbjct: 1815 VKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQ 1874 Query: 3007 SHESFSDWRGEL-LLALQQVFLEERSVLLAAFRTEL-----TALGTTDAVGL-LNCLEQR 3059 E + L Q EE S + A R +L A + +A+G +N L+ + Sbjct: 1875 YKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSK 1934 Query: 3060 IQ 3061 ++ Sbjct: 1935 LR 1936 Score = 133 bits (334), Expect = 4e-30 Identities = 280/1347 (20%), Positives = 551/1347 (40%), Gaps = 217/1347 (16%) Query: 414 FETDIVQRMEQETQRKLEQLRAELDEMYG------------QQIVQMKQELIRQHMAQME 461 F T ++ +E+E K+ + M QQ+ MK +I+++ A Sbjct: 777 FRTGVLAHLEEERDLKITDVIMAFQAMCRGYLARKAFAKRQQQLTAMK--VIQRNCAAYL 834 Query: 462 EMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILE 521 +++ + ++ +T E++++ + + + Q ++ ++L+++ + E Sbjct: 835 KLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTE 894 Query: 522 EKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVED----LKAEIVS 577 EK LQ QL+ E + + E R E E L+E L ED L+AE Sbjct: 895 EKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKK 954 Query: 578 ASESRKELELK-HEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEE 636 ++ +LE + E E K++LE + + EA++++L ++L ++ Sbjct: 955 MAQQMLDLEEQLEEEEAARQKLQLEKV-------------TAEAKIKKLEDEILVMDDQN 1001 Query: 637 LSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLI 696 KE +E RI+ L NL +++ L ++ K E+M E + + K+ + Sbjct: 1002 NKLSKERKLLEERIS--DLTTNLA-EEEEKAKNL-TKLKNKHESMISELEVRLKKEEKSR 1057 Query: 697 LEISKLKDLQQSLVNSKSEEMT-LQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELL 755 E+ KLK + + E++ LQ + ++++ ++EE+ + L + E+ K L Sbjct: 1058 QELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNAL 1117 Query: 756 EK--QMKEKENDLQEKF-AQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSK 812 +K +++ +DLQE ++ A N K ++ E++ + T + LDS ++ Sbjct: 1118 KKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDT-----LDSTATQ 1172 Query: 813 SK-DSVWEKEIEIL---IEEN--------EDLKQQCIQLNEEIEKQRNTFSFAEKNFEVN 860 + + E+E+ +L ++E ++++Q+ Q EE+ +Q F A+ N + N Sbjct: 1173 QELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKN 1232 Query: 861 YQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDED 920 Q L++E A L L + KQE+E+K K ++ +++S D + Sbjct: 1233 KQTLEKENADLAGELRVL--GQAKQEVEHKKK-----------KLEAQVQELQSKCSDGE 1279 Query: 921 KTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEV 980 + AE + ++ + + L + + ++L++ ++ LS QL+ L EE Sbjct: 1280 RA-RAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQ---ELLQEET 1335 Query: 981 KSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNK 1040 + +K VS + R+LE E S Q+ ++ + E +S +N Sbjct: 1336 R----QKLNVSTKLRQLE--------EERNSLQDQLDEEME-----AKQNLERHISTLNI 1378 Query: 1041 SFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELN 1100 + K + + + E + G++ Q++ + ++T++ +A + DKL+K N Sbjct: 1379 QLSDSKKKLQDFASTVEALEEGKKRFQKE-----IENLTQQYEEKA---AAYDKLEKTKN 1430 Query: 1101 VLKSEQNDLRLQMEAQRICLSLVYSTH--VDQVREYMENEKDKALCSLKEELIFAQEEKI 1158 L+ E +DL + ++ QR +S + DQ+ +N K A+E++ Sbjct: 1431 RLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKET 1490 Query: 1159 KELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPAL 1218 K L LE + ++ +E + K+ KA E Sbjct: 1491 KALSLARALE-EALEAKEELER-------TNKMLKAEME--------------------- 1521 Query: 1219 KCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEY----NKLLVLQ 1274 D +S D + +N EL+ + ++ E M T L ++ +E + L L+ Sbjct: 1522 -------DLVSSKDDVGKNVH-ELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLE 1573 Query: 1275 TRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKT 1334 + + GQ ++ E+N K +H T LED + K +L K Sbjct: 1574 VNMQALKGQFERDLQAR-DEQNEEKRRQLQRQLHEYETELED-----ERKQRALAAAAKK 1627 Query: 1335 KLEEQVQELE----SLISSLQQQLKETEQNYEAEIHCLQKRLQ------------AVSES 1378 KLE +++LE S I ++ +K+ + +A++ Q+ L+ A Sbjct: 1628 KLEGDLKDLELQADSAIKGREEAIKQL-RKLQAQMKDFQRELEDARASRDEIFATAKENE 1686 Query: 1379 TVPPSLPVDSVVITE--SDAQRTMYPGSCVKKNIDGTI--EFSGEFGVKEETNIVKLLEK 1434 SL D + + E + A+R K+ + + SG +++E ++ Sbjct: 1687 KKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIA 1746 Query: 1435 QYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMKLS 1494 Q +E+LEEE G E A S + QQ + NE L+ Sbjct: 1747 QLEEELEEE---------------------QGNME--AMSDRVRKATQQAEQLSNE--LA 1781 Query: 1495 QDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEMFS 1554 ++ Q E+ + + + K L +L E + E+K L E + Sbjct: 1782 TERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEA 1841 Query: 1555 KDKTFIVRQSIHDEISVSSMDAS-RQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHM 1613 ++K + S+ D ++++L Q+ED R ++ QY+E + A + Sbjct: 1842 REKQAATK-------SLKQKDKKLKEILL---QVEDER-KMAEQYKEQAEK----GNARV 1886 Query: 1614 RQMERQREDQEQLQEEIKRLNRQLAQRSSIDNE-NLVSERERVLLEELEALKQLSLAGRE 1672 +Q++RQ E+ E EE +R+N A R + E + +E + E+ ALK G E Sbjct: 1887 KQLKRQLEEAE---EESQRIN---ANRRKLQRELDEATESNEAMGREVNALKSKLRRGNE 1940 Query: 1673 KLCCELRNSSTQTQNGNENQGEVEEQT 1699 R S + N + E E T Sbjct: 1941 TSFVPSRRSGGRRVIENADGSEEETDT 1967 Score = 131 bits (329), Expect = 1e-29 Identities = 213/1071 (19%), Positives = 450/1071 (42%), Gaps = 162/1071 (15%) Query: 2 EDEERQKKLEAGKAKLAQFRQRKAQSDGQSPSKKQKKKRKTSSSKHDVSAHHDLNIDQSQ 61 E+E+R ++L+A + K+AQ + + + +QK + + +++ + D + Sbjct: 940 EEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDD 999 Query: 62 CNEMYINSSQRVESTVIPESTIMRTLHSGEITSHEQGFSVELESEISTTADDCSSEVNGC 121 N + +E + +T E + + ES IS E Sbjct: 1000 QNNKLSKERKLLEERISDLTT--NLAEEEEKAKNLTKLKNKHESMISELEVRLKKE---- 1053 Query: 122 SFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHEIEELNRELEEM 181 ++ + L+ + G + EQ A D + ++ +LA K+ E++ L++ Sbjct: 1054 ---EKSRQELEKLKRKLEGDASDFHEQIA-DLQAQIAELKMQLAKKEEELQAALARLDD- 1108 Query: 182 RVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQIQ 241 + L++++E E G I+ L +L R +++ ++ +L E+ + L+ + Sbjct: 1109 EIAQKNNALKKIRELE-------GHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTE 1161 Query: 242 F----------QQLQASE-----TLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLED 286 Q+L+A L+ + T + Q ++ H Q +EE LE Sbjct: 1162 LEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQ 1221 Query: 287 YQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEK----ETIIEELNTKIIEEE 342 +++ K + L+++ ++ + +V K+E++ K E ++EL +K + E Sbjct: 1222 FKRAKANLDKNKQTLEKENA--DLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGE 1279 Query: 343 KKTLELKDK-------LTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIK 395 + EL DK + + +L E + + ++ +++ ++ +L ++++ EE + Sbjct: 1280 RARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQE---LLQEETR 1336 Query: 396 QLMGTVEELQKRNHKDSQFETDIVQRME--QETQRKLEQLRAELDEMYGQQIVQMKQELI 453 Q + +L++ + + + + + ME Q +R + L +L + + K + Sbjct: 1337 QKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDS------KKKLQDF 1390 Query: 454 RQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQI-KLMNVAINELNIKLQDTNSQKEKL 512 + +EE K R + E+EN + Y D++ K N EL+ + D ++Q++ + Sbjct: 1391 ASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLV 1450 Query: 513 KEELGLILEEKCALQRQLEDLV-EELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDL 571 LE+K QR+ + L+ EE + S + + AE K K+LS L Sbjct: 1451 SN-----LEKK---QRKFDQLLAEEKNISSKYADERDRAEAEAREK---ETKALSLARAL 1499 Query: 572 KAEIVSASESRKELELKHEAEVTNYKIKLEM--LEKEKNAV------LDRMAESQEAELE 623 + + LE K E E TN +K EM L K+ V L++ + E ++E Sbjct: 1500 E----------EALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQME 1549 Query: 624 RLRTQLLFSHEEELSKLKEDLEIEHRINIEKLK----------DNLGIHYKQQIDGLQNE 673 ++TQL E+ + ED ++ +N++ LK D ++Q+ +E Sbjct: 1550 EMKTQL--EELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHE 1607 Query: 674 MSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSE------EMTLQINELQKE 727 ++E + ++ + +L ++ L+ S + + E ++ Q+ + Q+E Sbjct: 1608 YETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRE 1667 Query: 728 IEILR-----------QEEKEKGTLEQEVQELQ---LKTELLEKQMKEKENDLQEKFAQL 773 +E R + EK+ +LE ++ +LQ E KQ ++ +L E+ A Sbjct: 1668 LEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASS 1727 Query: 774 EAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLK 833 + + L+DEK+ LE + +EE + +E + + Sbjct: 1728 LSGRNALQDEKRRLEARIAQLEEELEEE-----------------QGNMEAMSDRVRKAT 1770 Query: 834 QQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKL 893 QQ QL+ E+ +R+T A+KN E Q+L+ + +++ L + + + ++KS + Sbjct: 1771 QQAEQLSNELATERST---AQKN-ESARQQLERQNK---ELRSKLHEMEGAVKSKFKSTI 1823 Query: 894 KAL-----------NEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELM 942 AL +E ++ ++K K E V + +M E ++ + Sbjct: 1824 AALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGN 1883 Query: 943 EKLEVTKR---EKLELSQRLSDLSEQLKQKHGEISFLNE----EVKSLKQE 986 +++ KR E E SQR++ +L+++ E + NE EV +LK + Sbjct: 1884 ARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSK 1934 Score = 117 bits (292), Expect = 3e-25 Identities = 242/1207 (20%), Positives = 495/1207 (41%), Gaps = 201/1207 (16%) Query: 624 RLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQF 683 +++ L + +EE + KED ++K K+ +Q+ + E+ QK + Sbjct: 847 KVKPLLQVTRQEEEMQAKED-------ELQKTKER-----QQKAENELKELEQKHSQLTE 894 Query: 684 EKDNLITKQNQLILEI-SKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGT-L 741 EK NL+ +Q Q E+ ++ ++++ L K E + E+ E+E +EE+++G L Sbjct: 895 EK-NLLQEQLQAETELYAEAEEMRVRLAAKKQE-----LEEILHEMEARLEEEEDRGQQL 948 Query: 742 EQEVQELQLKTELLEKQMKEKE-----------------NDLQEKFAQLEAENSILKDEK 784 + E +++ + LE+Q++E+E L+++ ++ +N+ L E+ Sbjct: 949 QAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKER 1008 Query: 785 KTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIE 844 K LE+ + T EE + K K+K E+E+ +++ E +Q+ +L ++E Sbjct: 1009 KLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLE 1068 Query: 845 KQRNTFSFAEKNFEVNYQEL--------QEEYACLLKVKDDLEDSKN--KQELEYKSKLK 894 + F + + EL +E A L ++ D++ N K+ E + + Sbjct: 1069 GDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHIS 1128 Query: 895 ALNEELHLQRINPTTVKMKSSVFDED----KTFVAETLEMGEVVEKDTTELMEKLEVTKR 950 L E+L +R + + E+ KT + +TL+ ++ + +++ V K+ Sbjct: 1129 DLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKK 1188 Query: 951 EKLELSQRLSDLSEQLKQKHGE-ISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENV 1009 E ++ ++++QKH + + L E+++ K+ K + + LE EN Sbjct: 1189 ALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLE-------KENA 1241 Query: 1010 Q-SCDTQVSSLLDGVVTMTSRGAEGSVSKVNK--SFGEESKIMVEDKV--------SFEN 1058 + + +V V + E V ++ S GE ++ + DKV S Sbjct: 1242 DLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTG 1301 Query: 1059 MTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRI 1118 M E K +L D + S L+ TQ ++ +++LNV LR Q+E +R Sbjct: 1302 MLNEAEGKAIKLAKD---VASLSSQLQDTQELLQEETRQKLNV----STKLR-QLEEERN 1353 Query: 1119 CLSLVYSTHVDQVREYMENEK--DKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQE 1176 L DQ+ E ME ++ ++ + +L +L + K+LQ T E Sbjct: 1354 SLQ-------DQLDEEMEAKQNLERHISTLNIQL----SDSKKKLQDF-------ASTVE 1395 Query: 1177 TGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDK-ENSGDYIS 1235 +EGK + QK + E T + + A DK E + + + Sbjct: 1396 ALEEGKK------RFQKEI----------------ENLTQQYEEKAAAYDKLEKTKNRLQ 1433 Query: 1236 ENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEE 1295 + D + D D Q + + L K ++++LL + +S + + D + E E+ Sbjct: 1434 QELDDLVVDL-----DNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREK 1488 Query: 1296 -----NLPKEETEFLSIHSQM--------TNLEDIDVNHKSKLSSLQDLEKTK--LEEQV 1340 +L + E L ++ +ED+ + ++ +LEK+K LE Q+ Sbjct: 1489 ETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQM 1548 Query: 1341 QELESLISSLQQQLKETEQ-------NYEAEIHCLQKRLQAVSEST------VPPSLPVD 1387 +E+++ + L+ +L+ TE N +A ++ LQA E + L Sbjct: 1549 EEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEY 1608 Query: 1388 SVVITESDAQRTMYPGSCVKKNIDG---TIEFSGEFGVKEETNIVKLLE------KQYQE 1438 + + QR + + KK ++G +E + +K +K L K +Q Sbjct: 1609 ETELEDERKQRAL--AAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQR 1666 Query: 1439 QLEEEVAKVIVSMSIAFAQQTELSRISGG----KENTASSKQAHAVCQQEQHYFNEMKLS 1494 +LE+ A + A + + + +E+ A++++A E+ E +L+ Sbjct: 1667 ELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAE-ELA 1725 Query: 1495 QDQIGFQTFETVDVKFKEEFKPLSKEL-GEHGKEILLSNSDPHDIPESKDCVLTISEEMF 1553 G + + + L +EL E G +S+ +++ ++ E Sbjct: 1726 SSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERS 1785 Query: 1554 SKDKTFIVRQ-----------SIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQ 1602 + K RQ +H+ + E ++ + +++ ++ +E Q Sbjct: 1786 TAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQ 1845 Query: 1603 QATELLRQAHMR------QMERQREDQEQLQEE-------IKRLNRQLAQRSSIDNENLV 1649 AT+ L+Q + Q+E +R+ EQ +E+ +K+L RQL + + +++ + Sbjct: 1846 AATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQL-EEAEEESQRIN 1904 Query: 1650 SERERVLLEELEALKQLSLAGRE--KLCCELRNSSTQTQNGNENQG---EVEEQTFKEKE 1704 + R ++ E EA + GRE L +LR + + + G +E E+E Sbjct: 1905 ANRRKLQRELDEATESNEAMGREVNALKSKLRRGNETSFVPSRRSGGRRVIENADGSEEE 1964 Query: 1705 LDRKPED 1711 D + D Sbjct: 1965 TDTRDAD 1971 Score = 106 bits (265), Expect = 4e-22 Identities = 232/1242 (18%), Positives = 512/1242 (41%), Gaps = 173/1242 (13%) Query: 2124 KCSELLLSKEQLQRD----IQERNEEIEKLEFRVRELEQALLVEDRKHFGAVEAKPELSL 2179 K + L + + +QR+ ++ RN + +L +V+ L Q E+ E + Sbjct: 815 KRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKER 874 Query: 2180 EVQLQAERDAIDRKEKEITN----LEEQL----------EQFREELENKNEEVQQLHMQL 2225 + + + E +++K ++T L+EQL E+ R L K +E++++ ++ Sbjct: 875 QQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEM 934 Query: 2226 EIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVE 2285 E + +E R Q+L+ E K M L ++E +A + Q A+ I++ E E Sbjct: 935 EARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAK-IKKLEDE 993 Query: 2286 IDQLNEQVTKLQQQLK--------ITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNR 2337 I +++Q KL ++ K +TT+ EEK + + L+ + E ++S+ E V+ + Sbjct: 994 ILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELE-VRLKK 1052 Query: 2338 EEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETA 2397 E EK +QEL + +K +A E+ L+ Q+ + + E++++ A Sbjct: 1053 E----------EKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAA 1102 Query: 2398 ----NEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKD 2453 ++E+ N LK K+ +L + L+ + +S ++ E + L Sbjct: 1103 LARLDDEIAQKNNALK----KIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEAL 1158 Query: 2454 KPELEVVL----TEDALKSLENQ---TYFKSFEENGKGSIINLETRLLQLESTVSAKDLE 2506 K ELE L T+ L++ Q K+ +E + E ++ ++ + E Sbjct: 1159 KTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSH----EAQVQEMRQKHAQAVEE 1214 Query: 2507 LTQCYKQIKDMQEQGQFETEMLQKKIVNLQ---KIVEEKVAAALVSQIQLEA-VQEYAKF 2562 LT+ +Q K + + L+K+ +L +++ + + +LEA VQE Sbjct: 1215 LTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSK 1274 Query: 2563 CQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVE 2622 C D + +E LN + +L +++ ++T ++E E + +++ + Q++ Sbjct: 1275 CSDGERARAE--------LND-KVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQ 1325 Query: 2623 IAEKNVLEKEKKLLELQKLL-----EGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEE- 2676 ++ + E+ ++ L + L E N + + E+ + Q++E +T + S+ + Sbjct: 1326 DTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKK 1385 Query: 2677 --SGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAE 2734 F + +EAL + E+ + ++ E+ E LQ++L + L Sbjct: 1386 KLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDN 1445 Query: 2735 AKEKLSILEKE----DETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQIL 2790 ++ +S LEK+ D+ +E +S A + D + +T + Sbjct: 1446 QRQLVSNLEKKQRKFDQLLAEEK-----------NISSKYADERDRAEAEAREKETKALS 1494 Query: 2791 VKNAGIQINLQSECSSEEVTEIISQFTEKIEKMQELHAAEILDMES------RHISETET 2844 + A EE E E++E+ ++ AE+ D+ S +++ E E Sbjct: 1495 LARA-----------LEEALEA----KEELERTNKMLKAEMEDLVSSKDDVGKNVHELEK 1539 Query: 2845 LKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREICSSDSGSDWGQG 2904 KR ++ +K + L+ +Q A DA E+ + + GQ Sbjct: 1540 SKRALETQMEEMKTQLEELEDELQ-------------ATEDAKLRLEV---NMQALKGQ- 1582 Query: 2905 IYLTHSQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQ-VLSLTESPYSDGEDH 2963 F+ + R E++E +++ + +E Q L+ +G+ Sbjct: 1583 --------FERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLK 1634 Query: 2964 SIQQVSEPWLEERKAYINTISSLKDLITKMQLQRE------AEVYDSSQSHE-SFSDWRG 3016 ++ ++ ++ R+ I + L+ + Q + E E++ +++ +E Sbjct: 1635 DLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEA 1694 Query: 3017 ELLLALQQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQ----------RIQEQGVE 3066 +L+ + + ER+ A E A ++ N L+ +++E+ E Sbjct: 1695 DLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEE 1754 Query: 3067 YQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQML 3126 Q ME + R++ Q L E +E+ + + E QQ + Q Sbjct: 1755 EQGNMEAMSDRVRKATQQAEQ------------LSNELATERSTAQKNESARQQLERQNK 1802 Query: 3127 EMQVELSSMKDRA-TELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFR 3185 E++ +L M+ ++ + +++ + +A+L+ ++ Q E + K+ + K+L+ Sbjct: 1803 ELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEIL 1862 Query: 3186 LEVKDKTDEVHLLNDTLASEQKKSRELQWAL---EKEKAKLGRSEERDKEELEDLKFSLE 3242 L+V+D+ + + ++L+ L E+E ++ + + + EL++ S E Sbjct: 1863 LQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNE 1922 Query: 3243 SQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQ 3284 + + L L + + ++ +R++ +A SEE+ Sbjct: 1923 AMGREVNALKSKLRRGNETSFVPSRRSGGRRVIENADGSEEE 1964 Score = 82.8 bits (203), Expect = 6e-15 Identities = 170/823 (20%), Positives = 351/823 (42%), Gaps = 127/823 (15%) Query: 2923 ESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINT 2982 ++E+ + ++++ L A E ++L E+ + ED Q +E RK Sbjct: 904 QAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAE-----RKKMAQQ 958 Query: 2983 ISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELL--------LALQQVFLEERSVLL 3034 + L++ + + + R+ + + E+L L+ ++ LEER L Sbjct: 959 MLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDL 1018 Query: 3035 AAFRTE-------LTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQK--ADRRSLLSE 3085 E LT L +++ LE R++++ Q + +K D + Sbjct: 1019 TTNLAEEEEKAKNLTKLKNKHE-SMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQ 1077 Query: 3086 IQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQ 3145 I L AQ+ K+ L +++E + + L+ I QK + + +++ ++ ++LQE Sbjct: 1078 IADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIR----ELEGHISDLQED 1133 Query: 3146 LSSEKMV-------VAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLL 3198 L SE+ +L EL K ELE TL + +EL A R + EV +L Sbjct: 1134 LDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQ-QELRAKREQ------EVTVL 1186 Query: 3199 NDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLK---FSLESQKQRNLQLNLLL 3255 L E+ +S E Q +++ + K ++ E E+LE K +L+ KQ + N L Sbjct: 1187 KKAL-DEETRSHEAQ--VQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADL 1243 Query: 3256 EQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELH 3315 + ++L +++Q++E ++ +AQ+ E Q + + E+ R + D+ +L Sbjct: 1244 AGELRVLGQAKQEVEHKKKKLEAQVQELQSK------CSDGERAR----AELNDKVHKLQ 1293 Query: 3316 AQLQSSDGT---GQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQM 3372 +++S G + + ++D+ L QL++ ELL E + KL+ +Q+ Sbjct: 1294 NEVESVTGMLNEAEGKAIKLAKDVAS-LSSQLQDTQ----ELLQEETRQKLNVSTKLRQL 1348 Query: 3373 EKDRQVHRKTLQTEQEAN--------------TEGQKKMHE--------------LQSKV 3404 E++R + L E EA ++ +KK+ + Q ++ Sbjct: 1349 EEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEI 1408 Query: 3405 EDLQRQLEEKRQQVYKLDLEGQRLQGIMQEF------QKQELEREEKRESR--RILYQNL 3456 E+L +Q EEK KL+ RLQ + + Q+Q + EK++ + ++L + Sbjct: 1409 ENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEK 1468 Query: 3457 NEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELE----MIRQKLQ 3512 N + ++ DR + E ETK + A+ +E ELE M++ +++ Sbjct: 1469 NISSKYADERDRAE----AEAREKETKALSLARALE---EALEAKEELERTNKMLKAEME 1521 Query: 3513 CVASKLQVLPQKASERLQFETADDEDFIWVQENIDEIILQLQKLTGQ-QGEEPSLVSPST 3571 + S + + E + + A ++ ++E+ QL++L + Q E + + Sbjct: 1522 DLVSSKDDVGKNVHELEKSKRA-------LETQMEEMKTQLEELEDELQATEDAKLRLEV 1574 Query: 3572 SCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRFSLN 3631 + +L + R +L Q E++ L+ + + E ++ R+ A +++ L Sbjct: 1575 NMQALKGQFER---DLQARDEQNEEKRRQLQRQLHEYETELEDERKQRA-LAAAAKKKLE 1630 Query: 3632 GGANIEAIIASEKEVWNREKLTLQKSLKRAEAEVYKLKAELRN 3674 G + + ++ + RE+ K L++ +A++ + EL + Sbjct: 1631 GDLK-DLELQADSAIKGREEAI--KQLRKLQAQMKDFQRELED 1670 Score = 76.3 bits (186), Expect = 6e-13 Identities = 119/577 (20%), Positives = 241/577 (41%), Gaps = 64/577 (11%) Query: 3153 VAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQK---KS 3209 V + E+ + EL+ T + Q K EL+ + T+E +LL + L +E + ++ Sbjct: 854 VTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEA 913 Query: 3210 RELQWALEKEKAKLGR---SEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQ 3266 E++ L +K +L E EE ED L++++++ Q L LE+Q + ++ Sbjct: 914 EEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAAR 973 Query: 3267 QKIESQRMLYDAQLS---------EEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQ 3317 QK++ +++ +A++ ++Q L + L E RI ++++ L E E Sbjct: 974 QKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEE--RISDLTTNLAEEEEKAKN 1031 Query: 3318 LQSSDGTGQS---------RPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQT 3368 L +S + S L++L+++LE S E + + + + Sbjct: 1032 LTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQ 1091 Query: 3369 RQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLE---- 3424 + E++ Q L E KK+ EL+ + DLQ L+ +R K + + Sbjct: 1092 LAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDL 1151 Query: 3425 GQRLQGIMQEFQ--------KQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQ 3476 G+ L+ + E + +QEL R ++ + +L + L+E T + Q Sbjct: 1152 GEELEALKTELEDTLDSTATQQEL-RAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQ 1210 Query: 3477 KIEGETKESNYAKLIEMN---------GGGTGCNHELEMIRQKLQCVASKLQVLPQKASE 3527 +E T++ K + N EL ++ Q Q V K + L + E Sbjct: 1211 AVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQE 1270 Query: 3528 RLQFETADDEDF-IWVQENIDEIILQLQKLTGQQGE-EPSLVSPSTSCGSLTERL----- 3580 LQ + +D E + + + ++ +++ +TG E E + + SL+ +L Sbjct: 1271 -LQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQE 1329 Query: 3581 -----LRQNAELTGHISQLTEEKNDLRNMV---MKLEEQIRWYRQTGAGRDNSSRFSLNG 3632 RQ ++ + QL EE+N L++ + M+ ++ + + T + + S+ L Sbjct: 1330 LLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQD 1389 Query: 3633 GANIEAIIASEKEVWNREKLTLQKSLKRAEAEVYKLK 3669 A+ + K+ + +E L + + A KL+ Sbjct: 1390 FASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLE 1426 Score = 71.6 bits (174), Expect = 1e-11 Identities = 92/466 (19%), Positives = 200/466 (42%), Gaps = 52/466 (11%) Query: 3173 AQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKE 3232 A + L+ + +RL K K LL T E+ +++E + KE+ + +E ++ E Sbjct: 831 AAYLKLRNWQWWRLFTKVKP----LLQVTRQEEEMQAKEDELQKTKERQQKAENELKELE 886 Query: 3233 E----LEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNL 3288 + L + K L+ Q Q +L E+ + L +Q++E +A+L EE+ R Sbjct: 887 QKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQ 946 Query: 3289 ELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDL---------LKE 3339 +LQ + ++ ++ L+ E +LQ T +++ +++ L + Sbjct: 947 QLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSK 1006 Query: 3340 LQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHE 3399 +K LEE+ S + L E E+ + + + + E L+ E+++ E +K + Sbjct: 1007 ERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRK 1066 Query: 3400 LQSKVEDLQRQLEEKRQQVYKLDLE----GQRLQGIMQEFQKQELEREEKRESRRILYQN 3455 L+ D Q+ + + Q+ +L ++ + LQ + + ++ + R L + Sbjct: 1067 LEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGH 1126 Query: 3456 LNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMIRQKLQ--- 3512 +++ LQ+ ++ E N A+ + + G ELE ++ +L+ Sbjct: 1127 ISD---------------LQEDLDSERAARNKAEKQKRDLG-----EELEALKTELEDTL 1166 Query: 3513 -CVASKLQVLPQKASERLQFETADDEDF----IWVQENIDEIILQLQKLTGQQGEEPSLV 3567 A++ ++ ++ E + A DE+ VQE + +++LT Q + Sbjct: 1167 DSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQ---FK 1223 Query: 3568 SPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKLEEQIR 3613 + + L ++NA+L G + L + K ++ + KLE Q++ Sbjct: 1224 RAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQ 1269 Score = 70.5 bits (171), Expect = 3e-11 Identities = 90/425 (21%), Positives = 184/425 (43%), Gaps = 61/425 (14%) Query: 169 HEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQ----------QAR 218 HE+E+ R LE T E QL+E E ++ + +L N+Q QAR Sbjct: 1535 HELEKSKRALE----TQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQAR 1590 Query: 219 REKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADL----LQAKQQILTHQ 274 E++E R +L Q + + + + + L + DL LQA I + Sbjct: 1591 DEQNEEKRR--QLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGRE 1648 Query: 275 Q---QLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETII 331 + QL + ++D+Q++ ED +++I E +KK ++ + +Q +E + Sbjct: 1649 EAIKQLRKLQAQMKDFQRELEDARAS----RDEIFATAKENEKKAKSLEADLMQLQEDLA 1704 Query: 332 EELNTKI---IEEEKKTLELKDKLTTADKLLGE---LQEQIVQKNQEIKNMKLELTNSKQ 385 + +E+E+ EL L+ + L E L+ +I Q +E++ + + Sbjct: 1705 AAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSD 1764 Query: 386 KERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQI 445 + R+++++ +QL + + K+ + Q+ +R+ ++LR++L EM G Sbjct: 1765 RVRKATQQAEQLSNELATERSTAQKN--------ESARQQLERQNKELRSKLHEMEGAVK 1816 Query: 446 VQMKQEL--IRQHMAQMEEMKTRHKGEMENALRSYSN--------ITVNEDQIKLMNVAI 495 + K + + +AQ+EE + E + A +S + ED+ K+ Sbjct: 1817 SKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYK 1876 Query: 496 NEL---NIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVE-------ELSFSREQIQ 545 + N +++ Q E+ +EE I + LQR+L++ E E++ + +++ Sbjct: 1877 EQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLR 1936 Query: 546 RARQT 550 R +T Sbjct: 1937 RGNET 1941 Score = 58.5 bits (140), Expect = 1e-07 Identities = 91/505 (18%), Positives = 214/505 (42%), Gaps = 75/505 (14%) Query: 4 EERQKKLEAGKAKLAQFRQRKAQSDGQSPSKKQKKKRKTSSSKHDVSAHHDLNIDQSQCN 63 E++Q+K + A+ + A ++ ++ ++K+ K S + + + + N Sbjct: 1454 EKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTN 1513 Query: 64 EMYINSSQRVESTVIPESTIMRTLHSGEITSHEQGFSVELESEISTTADDCSSEVNGCSF 123 +M +E V + + + +H E+ ++ ++E E+ T ++ E+ Sbjct: 1514 KML---KAEMEDLVSSKDDVGKNVH--ELEKSKRALETQME-EMKTQLEELEDELQATED 1567 Query: 124 V-MRTGKPTNLLR---EEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHEI-------E 172 +R L+ E + D +E+ + L E+EL ++ + + Sbjct: 1568 AKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKK 1627 Query: 173 ELNRELEEMRVTYGT------EGLQQLQEFEAAIKQ-----------RDGIITQLTANLQ 215 +L +L+++ + + E ++QL++ +A +K RD I N + Sbjct: 1628 KLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEK 1687 Query: 216 QARREKDETMR--EFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAA--DLLQAKQQIL 271 +A+ + + M+ E L E+++K Q ++ + +E L +S A + + + +I Sbjct: 1688 KAKSLEADLMQLQEDLAAAERARK-QADLEKEELAEELASSLSGRNALQDEKRRLEARIA 1746 Query: 272 THQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETII 331 +++LEE+ +E + T Q L E+ ++ N+ Q+ E Sbjct: 1747 QLEEELEEEQGNMEAMSDRVRKATQQAEQLSN-----ELATERSTAQKNESARQQLERQN 1801 Query: 332 EELNTKIIEEEKKTL-ELKDKLTTADKLLGELQEQIVQ--------------KNQEIKNM 376 +EL +K+ E E + K + + + +L+EQ+ Q K++++K + Sbjct: 1802 KELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEI 1861 Query: 377 KLELTNSKQKERQSSEE-------IKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRK 429 L++ + ++ Q E+ +KQL +EE ++ E+ + ++ QR+ Sbjct: 1862 LLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEE--------ESQRINANRRKLQRE 1913 Query: 430 LEQLRAELDEMYGQQIVQMKQELIR 454 L++ E +E G+++ +K +L R Sbjct: 1914 LDE-ATESNEAMGREVNALKSKLRR 1937 >gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo sapiens] Length = 1945 Score = 157 bits (396), Expect = 3e-37 Identities = 224/1105 (20%), Positives = 486/1105 (43%), Gaps = 167/1105 (15%) Query: 157 LEMMESELAGKQHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQ 216 ++ E EL + ++ EL+E+ + QL E + ++++ T+L A ++ Sbjct: 861 MQAKEDELQKTKERQQKAENELKELEQKHS-----QLTEEKNLLQEQLQAETELYAEAEE 915 Query: 217 ARREKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQ 276 R + L + Q+L+ +++A A+ + QQ+L ++Q Sbjct: 916 MR----------VRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQ 965 Query: 277 LEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYE------------------------MEQ 312 LEE++ + Q +K +I L+++I V + E+ Sbjct: 966 LEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEE 1025 Query: 313 DKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELK--------------DKLTTADKL 358 ++K +N K + + E++I EL ++ +EEK EL+ +++ Sbjct: 1026 EEKAKNLTKLK-NKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQ 1084 Query: 359 LGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDI 418 + EL+ Q+ +K +E++ L + ++ + ++I++L G + +LQ+ + + + Sbjct: 1085 IAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQE-DLDSERAARNK 1143 Query: 419 VQRMEQETQRKLEQLRAELDEMYG-------------QQIVQMKQEL---IRQHMAQMEE 462 ++ +++ +LE L+ EL++ Q++ +K+ L R H AQ++E Sbjct: 1144 AEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQE 1203 Query: 463 MKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEE 522 M+ +H +E +T +Q K +++ L+ N+ LG +E Sbjct: 1204 MRQKHAQAVE-------ELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQE 1256 Query: 523 KCALQRQLEDLVEELSFSREQIQRARQTIAEQESK-----------LNEAH-KSLSTVED 570 +++LE V+EL +RAR + ++ K LNEA K++ +D Sbjct: 1257 VEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKD 1316 Query: 571 LKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAE--LER---- 624 + A + S + +EL + + N KL LE+E+N++ D++ E EA+ LER Sbjct: 1317 V-ASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHIST 1375 Query: 625 LRTQLLFSHE--EELSKLKEDLEIEHRINIEKLKDNLGIHYKQ------QIDGLQNEMSQ 676 L QL S + ++ + E LE E + +K +NL Y++ +++ +N + Q Sbjct: 1376 LNIQLSDSKKKLQDFASTVEALE-EGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQ 1434 Query: 677 KIETMQFEKDNLITKQNQLILEI-SKLKDLQQSLVNSKS-------EEMTLQINELQKEI 728 +++ + + DN Q QL+ + K + Q L K+ E + +KE Sbjct: 1435 ELDDLVVDLDN----QRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKET 1490 Query: 729 EILRQEEKEKGTLEQEVQELQLKTELLEKQMKE---KENDLQEKFAQLEAENSILK---D 782 + L + LE + +EL+ ++L+ +M++ ++D+ + +LE L+ + Sbjct: 1491 KALSLARALEEALEAK-EELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQME 1549 Query: 783 EKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENED----LKQQCIQ 838 E KT + L+ +++ +L + ++ +E++++ E+NE+ L++Q + Sbjct: 1550 EMKTQLEELEDELQATEDAKLRL--EVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHE 1607 Query: 839 LNEEIE---KQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKA 895 E+E KQR + A+K E + ++L+ + +K +++ KQ + ++++K Sbjct: 1608 YETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREE----AIKQLRKLQAQMKD 1663 Query: 896 LNEELHLQRINPTTV-------KMKSSVFDEDKTFVAETLEMGEVVEK----DTTELMEK 944 EL R + + + K+ + D + E L E K + EL E+ Sbjct: 1664 FQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEE 1723 Query: 945 L-------EVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCREL 997 L + EK L R++ L E+L+++ G + +++ V+ Q+ EQ+S Sbjct: 1724 LASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLS-----N 1778 Query: 998 EIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFE 1057 E+ + A+ +S Q+ + + EG+V KS + + +E K++ Sbjct: 1779 ELATERSTAQKNESARQQLER-QNKELRSKLHEMEGAV----KSKFKSTIAALEAKIAQL 1833 Query: 1058 NMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQR 1117 V +E++++Q L K+ Q + K+ ++ ++E+ + R++ ++ Sbjct: 1834 EEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKE-QAEKGNARVKQLKRQ 1892 Query: 1118 ICLSLVYSTHVDQVREYMENEKDKA 1142 + + S ++ R ++ E D+A Sbjct: 1893 LEEAEEESQRINANRRKLQRELDEA 1917 Score = 154 bits (389), Expect = 2e-36 Identities = 229/1044 (21%), Positives = 454/1044 (43%), Gaps = 145/1044 (13%) Query: 1935 ERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEA---MKAEAGPVE 1991 E ++Q K D + + ++ A N L+ELE + Q+ EE+ LL Q +A + AEA + Sbjct: 858 EEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMR 917 Query: 1992 QQLL---QETEKLMKEKLEVQCQAEKVR-DDLQKQVKALE---IDVEEQVSRFIELEQEK 2044 +L QE E+++ E +E + + E+ R LQ + K + +D+EEQ +E E+ Sbjct: 918 VRLAAKKQELEEILHE-MEARLEEEEDRGQQLQAERKKMAQQMLDLEEQ----LEEEEAA 972 Query: 2045 NTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKL-----EQQLKVVPR 2099 +L + +A K+LE +D+Q ER + ++ I L E++ K Sbjct: 973 RQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNL 1032 Query: 2100 FQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQA 2159 + ++H++ + +L LK++ EL K +L+ D + +E+I L+ ++ EL+ Sbjct: 1033 TKLKNKHESM-ISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQ 1091 Query: 2160 LLVEDRKHFGAV------------------EAKPELS-LEVQLQAERDAIDRKEKEITNL 2200 L ++ + A+ E + +S L+ L +ER A ++ EK+ +L Sbjct: 1092 LAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDL 1151 Query: 2201 EEQLEQFREELEN--------------KNEEVQQLHMQLEIQKKESTTRLQELEQEN--- 2243 E+LE + ELE+ + +EV L L+ + + ++QE+ Q++ Sbjct: 1152 GEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQA 1211 Query: 2244 -----------KLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQ 2292 K K +++K +++ +A + VL Q QE E + +L Q Sbjct: 1212 VEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVL----GQAKQEVEHKKKKLEAQ 1267 Query: 2293 VTKLQQQLKITTDNKVIEEKNELIRDLETQIEC---LMSDQECVKRNREEEIEQLNEVI- 2348 V +LQ K + + E N+ + L+ ++E ++++ E +++ L+ + Sbjct: 1268 VQELQS--KCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQ 1325 Query: 2349 --EKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKN 2406 ++L QE S L EE +SL+ QLD + K LE+ + T N +++ K Sbjct: 1326 DTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKK 1385 Query: 2407 VLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDAL 2466 L++ + L + KR ++ +E + E A D L K K L+ L +D + Sbjct: 1386 KLQDFASTVEALEE---GKKRFQKEIENLTQQYEEKA-AAYDKLEKTKNRLQQEL-DDLV 1440 Query: 2467 KSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETE 2526 L+NQ S E + +LL E +S+K D +++ + E Sbjct: 1441 VDLDNQRQLVSNLEKKQRKF----DQLLAEEKNISSK----------YADERDRAEAEAR 1486 Query: 2527 MLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLRE 2586 + K ++L + +EE AL ++ +LE + K ++ S + N+ L + + Sbjct: 1487 EKETKALSLARALEE----ALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKR 1542 Query: 2587 ------DELGSDISALTLRISELESQVVEMHTSLILEKEQVE-IAEKNVLEKEKKLLELQ 2639 +E+ + + L + E + + ++ K Q E + + E+K +LQ Sbjct: 1543 ALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQ 1602 Query: 2640 KLLE------GNEKKQR---EKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAES 2690 + L +E+KQR KK+ D++ L+ + E +L L+A+ Sbjct: 1603 RQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEA-IKQLRKLQAQM 1661 Query: 2691 VATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAK--EKLSILEKEDET 2748 + EL + +++ E SL+ DL Q+++ LA A+ K + LEKE+ Sbjct: 1662 KDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEE-- 1719 Query: 2749 EVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSS-E 2807 L++ +AS G + + ++ ++ + A ++ L+ E + E Sbjct: 1720 -----------------LAEELASSLSG--RNALQDEKRRLEARIAQLEEELEEEQGNME 1760 Query: 2808 EVTEIISQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVI 2867 +++ + + T++ E++ A E ++ S + L+R++ L E G +K+ Sbjct: 1761 AMSDRVRKATQQAEQLSNELATE-RSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKF 1819 Query: 2868 QCLRSKEGSSIPELAHSDAYQTRE 2891 + + + I +L + RE Sbjct: 1820 KSTIAALEAKIAQLEEQVEQEARE 1843 Score = 150 bits (380), Expect = 2e-35 Identities = 235/1202 (19%), Positives = 516/1202 (42%), Gaps = 177/1202 (14%) Query: 225 MREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLL 284 ++ L++T Q +++Q + +LQ ++ + + +L + +Q+ QL E+ +LL Sbjct: 848 VKPLLQVTRQEEEMQAKEDELQKTKERQQKAEN----ELKELEQK----HSQLTEEKNLL 899 Query: 285 EDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKK 344 ++ LQ + ++Y ++ +V + K+ QE E I+ E+ ++ EEE + Sbjct: 900 QEQ-------------LQAETELYAEAEEMRVRLAAKK--QELEEILHEMEARLEEEEDR 944 Query: 345 TLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEEL 404 +L+ + + + +L+EQ+ ++ + ++LE ++ K ++ +EI + +L Sbjct: 945 GQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKL 1004 Query: 405 QKRNHKDSQFETDIVQRM--EQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEE 462 K + +D+ + E+E + L +L+ + + M + V++K+E + ++E+ Sbjct: 1005 SKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKE--EKSRQELEK 1062 Query: 463 MKTRHKGEMENALRSYSNITVNEDQIKL--------MNVAINELNIKLQDTNSQKEKLKE 514 +K + +G+ + +++ ++K+ + A+ L+ ++ N+ +K++E Sbjct: 1063 LKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRE 1122 Query: 515 ELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAE 574 L+ + DL E+L R AR +Q+ L E ++L T + + Sbjct: 1123 -----------LEGHISDLQEDLDSER----AARNKAEKQKRDLGEELEALKTELE---D 1164 Query: 575 IVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHE 634 + ++ +++EL K E EVT K LD S EA+++ +R + H Sbjct: 1165 TLDSTATQQELRAKREQEVTVLK-----------KALDEETRSHEAQVQEMRQK----HA 1209 Query: 635 EELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQ 694 + + +L E LE ++ K NL + KQ ++ +++ ++ + K + K+ + Sbjct: 1210 QAVEELTEQLE-----QFKRAKANLDKN-KQTLEKENADLAGELRVLGQAKQEVEHKKKK 1263 Query: 695 LILEISKLKDLQQSLVNSKSEEMTLQINELQKEIE----ILRQEEKEKGTLEQEV----Q 746 L ++ +L+ +++ E+ ++++LQ E+E +L + E + L ++V Sbjct: 1264 LEAQVQELQSKCSDGERARA-ELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSS 1322 Query: 747 ELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFL 806 +LQ ELL+++ ++K N + K QLE E + L+D+ L++ ++ + + + + Sbjct: 1323 QLQDTQELLQEETRQKLN-VSTKLRQLEEERNSLQDQ---LDEEMEAKQNLERHISTLNI 1378 Query: 807 DSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQE 866 SK K + +E L E +K F+ + L + Sbjct: 1379 QLSDSKKKLQDFASTVEALEE-------------------------GKKRFQKEIENLTQ 1413 Query: 867 EYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAE 926 +Y D LE +KN+ + E L L +L QR + ++ K FD+ +AE Sbjct: 1414 QYEEKAAAYDKLEKTKNRLQQE----LDDLVVDLDNQRQLVSNLEKKQRKFDQ---LLAE 1466 Query: 927 TLEMGE--VVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLK 984 + E+D E + + TK L L++ L + E ++ L E++ L Sbjct: 1467 EKNISSKYADERDRAEAEAREKETK--ALSLARALEEALEAKEELERTNKMLKAEMEDLV 1524 Query: 985 QEKEQVSLRCRELEIIINHNRA--ENVQSCDTQVSSLLDGV---------VTMTSRGAEG 1033 K+ V ELE RA ++ TQ+ L D + + + + +G Sbjct: 1525 SSKDDVGKNVHELE---KSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKG 1581 Query: 1034 SVSK---VNKSFGEESKIMVEDKVSFENMTVGEESKQEQLIL---DHLPSVTKESSLRAT 1087 + EE + ++ ++ + +E KQ L L K+ L+A Sbjct: 1582 QFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQAD 1641 Query: 1088 QPSE-NDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSL 1146 + ++ K+L L+++ D + ++E R +++T + ++ E D L L Sbjct: 1642 SAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEAD--LMQL 1699 Query: 1147 KEELIFAQE-EKIKELQK---IHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYF 1202 +E+L A+ K +L+K +L DE + L I +L++ + EE Sbjct: 1700 QEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEE---- 1755 Query: 1203 LQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLLNK 1262 Q + + A + ++ + ++ + Q + ++ + +H + Sbjct: 1756 -QGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGA 1814 Query: 1263 VTEEY-NKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNH 1321 V ++ + + L+ +++++ EE + +E E + +L+ D Sbjct: 1815 VKSKFKSTIAALEAKIAQL-------------EEQVEQEARE---KQAATKSLKQKDKKL 1858 Query: 1322 KSKLSSLQDLEK--TKLEEQVQELESLISSLQQQLKETE---QNYEAEIHCLQKRLQAVS 1376 K L ++D K + +EQ ++ + + L++QL+E E Q A LQ+ L + Sbjct: 1859 KEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEAT 1918 Query: 1377 ES 1378 ES Sbjct: 1919 ES 1920 Score = 150 bits (380), Expect = 2e-35 Identities = 227/1071 (21%), Positives = 462/1071 (43%), Gaps = 156/1071 (14%) Query: 1563 QSIHDEISV---SSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLR--QAHMRQME 1617 + + DEI V + S++ L EE++ D+ L + ++ + T+L ++ + ++E Sbjct: 988 KKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELE 1047 Query: 1618 RQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCE 1677 + + +E+ ++E+++L R+L +S +E + L ++ LK E+L Sbjct: 1048 VRLKKEEKSRQELEKLKRKLEGDASDFHEQIAD-----LQAQIAELKMQLAKKEEELQAA 1102 Query: 1678 LRNSSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLE 1737 L + N ++ +EL+ D+ E L +ER A KA + + E Sbjct: 1103 LARLDDEIAQKNNALKKI-------RELEGHISDLQ-EDLDSERAARNKAEKQKRDLGEE 1154 Query: 1738 VVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPS 1797 + +E+T LD ++ Q + + E E +V +E TR + + Sbjct: 1155 LEALKTELEDT--------LDSTATQQELRA---KREQEVTVLKKALDEETRSHEAQVQE 1203 Query: 1798 YSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKL 1857 M K + EL+++L + A +D + L + A + Sbjct: 1204 ------------MRQKHAQAVEELTEQLEQFKRAKANLDKNKQTL-----EKENADLAGE 1246 Query: 1858 LEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVEL 1917 L + + ++EH K ++E + + ++ + + EL +++H+ E + L Sbjct: 1247 LRVLGQAKQEVEHKKKKLEAQVQEL---QSKCSDGERARAELNDKVHKLQNEVESVTGML 1303 Query: 1918 SKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLS 1977 ++AEG A + Q+Q+ +++ ++ L S +L++LE E+ +Q++ + Sbjct: 1304 NEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEM 1363 Query: 1978 RQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRF 2037 K+ ++ + QL +KL V+ E+ + QK+++ L EE+ + + Sbjct: 1364 EAKQNLERHISTLNIQLSDSKKKLQDFASTVEA-LEEGKKRFQKEIENLTQQYEEKAAAY 1422 Query: 2038 IELEQEKN-------TELMDLRQQNQALEKQLEKMRKF----LDEQAIDREH--ERDVFQ 2084 +LE+ KN ++DL Q Q + +K RKF +E+ I ++ ERD + Sbjct: 1423 DKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAE 1482 Query: 2085 QEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNE 2144 E ++ E + + R + E+E+ LK + + +L+ SK+ + +++ E + Sbjct: 1483 AEAREKETKALSLARALEEALEAKEELERTNKMLKAEME---DLVSSKDDVGKNVHELEK 1539 Query: 2145 EIEKLEFRVRELEQALLVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQL 2204 LE ++ E++ L LE +LQA DA R E N++ Sbjct: 1540 SKRALETQMEEMKTQL----------------EELEDELQATEDAKLRLE---VNMQALK 1580 Query: 2205 EQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMS 2264 QF +L+ ++E+ ++ QL+ Q E T L++ ++ L +KL +K+ + Sbjct: 1581 GQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKD---LE 1637 Query: 2265 TQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNK-----VIEEKNELIRDL 2319 Q + G+ +E ++ +L Q+ Q++L+ ++ +E + + L Sbjct: 1638 LQADSAIKGR-----EEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSL 1692 Query: 2320 ETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQ 2379 E + L D +R R++ + E+ E+L L+ ++L +E K + Sbjct: 1693 EADLMQLQEDLAAAERARKQADLEKEELAEELASSLS--------GRNALQDE----KRR 1740 Query: 2380 LDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIP 2439 L+ IA+ LE+++E M M + +++ + QL+ EL + ER + +K +S Sbjct: 1741 LEARIAQ---LEEELEEEQGNMEAMSDRVRKATQQAEQLSNELAT---ERSTAQKNES-- 1792 Query: 2440 ENSVNVAIDHLSKDKPELEVVL--TEDALKSLENQTYFKSFEENGKGSIINLETRLLQLE 2497 A L + EL L E A+KS K +I LE ++ QLE Sbjct: 1793 ------ARQQLERQNKELRSKLHEMEGAVKS------------KFKSTIAALEAKIAQLE 1834 Query: 2498 STVSAKDLELTQCYKQIKDMQEQGQFETEMLQ----KKIVNLQKIVEEKVAAALVSQI-- 2551 V + E K +K Q+ + + +LQ +K+ K EK A V Q+ Sbjct: 1835 EQVEQEAREKQAATKSLK--QKDKKLKEILLQVEDERKMAEQYKEQAEK-GNARVKQLKR 1891 Query: 2552 QLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLRE--DELGSDISALTLRI 2600 QLE +E ++Q I++ + + L++ E + +G +++AL ++ Sbjct: 1892 QLEEAEE------ESQRINANRRKLQ-RELDEATESNEAMGREVNALKSKL 1935 Score = 145 bits (365), Expect = 1e-33 Identities = 253/1164 (21%), Positives = 511/1164 (43%), Gaps = 155/1164 (13%) Query: 2386 EKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNV 2445 E A E +++ E +N LKE K +QLT+E L+ + ++ ++ + E + V Sbjct: 860 EMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEE-MRV 918 Query: 2446 AIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKG---SIINLETRLLQLESTVSA 2502 L+ K ELE +L E + E + + + K +++LE +L + E+ Sbjct: 919 ---RLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQK 975 Query: 2503 KDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEA-VQEYAK 2561 LE +IK ++++ + K+ +K++EE+++ + + E + K Sbjct: 976 LQLEKVTAEAKIKKLEDEILVMDDQ-NNKLSKERKLLEERISDLTTNLAEEEEKAKNLTK 1034 Query: 2562 FCQDNQTISSE------PERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLI 2615 ++++ SE E + Q L +L+ +L D S +I++L++Q+ E+ L Sbjct: 1035 LKNKHESMISELEVRLKKEEKSRQELEKLKR-KLEGDASDFHEQIADLQAQIAELKMQLA 1093 Query: 2616 LEKEQV---------EIAEKN-----VLEKEKKLLELQKLLEGNE--KKQREKEKKRSPQ 2659 ++E++ EIA+KN + E E + +LQ+ L+ + + EK+K+ + Sbjct: 1094 KKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGE 1153 Query: 2660 DVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMT 2719 ++E LKT ELE +S AT+ EL + +E+ + ++ L +ET Sbjct: 1154 ELEALKT---------------ELEDT-LDSTATQQELRAKREQEVTVLKKALDEETR-- 1195 Query: 2720 SLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKA-CMFEPLPIKLSKSIASQTDGTL 2778 S + + ++R A+A E+L+ ++++ K+A + L K A Sbjct: 1196 SHEAQVQEMRQKHAQAVEELT-------EQLEQFKRAKANLDKNKQTLEKENADLAGELR 1248 Query: 2779 KISSSNQTPQILVKNAGIQIN-LQSECSSEEVTEIISQFTEKIEKMQ---ELHAAEILDM 2834 + + Q + K Q+ LQS+CS E ++ +K+ K+Q E + + Sbjct: 1249 VLGQAKQEVEHKKKKLEAQVQELQSKCSDGERAR--AELNDKVHKLQNEVESVTGMLNEA 1306 Query: 2835 ESRHIS---ETETLKREHYVAVQLLKEECGTLKAVIQCLRS--KEGSSIPELAHSDAYQT 2889 E + I + +L + +LL+EE V LR +E +S+ + + Sbjct: 1307 EGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAK 1366 Query: 2890 REICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESESATDSFPKKIKGLLR------AVH 2943 + + S + I L+ S+ E E F K+I+ L + A + Sbjct: 1367 QNLERHISTLN----IQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAY 1422 Query: 2944 NEGMQVLSLTESPYSD---GEDHSIQQVSEPWLEERKAYINTISSLKDLITKMQLQR--- 2997 ++ + + + D D+ Q VS ++RK + ++ K++ +K +R Sbjct: 1423 DKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRK-FDQLLAEEKNISSKYADERDRA 1481 Query: 2998 EAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTALGTTDAVGL----- 3052 EAE + S + E L A ++ LE + +L A +L + + D VG Sbjct: 1482 EAEAREKETKALSLARALEEALEAKEE--LERTNKMLKAEMEDLVS--SKDDVGKNVHEL 1537 Query: 3053 ---LNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEI--QALHAQMNGRKITLKREQESE 3107 LE +++E + + + LQ + L E+ QAL Q R + + EQ E Sbjct: 1538 EKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFE-RDLQARDEQNEE 1596 Query: 3108 KPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLEL 3167 K +Q Q Q+ E + EL + +Q + +L+ +L +L+ Sbjct: 1597 KR---------RQLQRQLHEYETELEDER-------KQRALAAAAKKKLEGDLKDLELQA 1640 Query: 3168 ETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSE 3227 ++ +K + + +K+L + ++KD E+ + + SR+ +A KE K +S Sbjct: 1641 DSAIKGREEAIKQLRKLQAQMKDFQRELE--------DARASRDEIFATAKENEKKAKSL 1692 Query: 3228 ERDKEEL-EDLKFSLESQKQRNLQLNLLLEQQ------KQLLNESQQKIESQRMLYDAQL 3280 E D +L EDL + ++KQ +L+ L E+ + L + ++++E++ + +L Sbjct: 1693 EADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEEL 1752 Query: 3281 SEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKEL 3340 EEQG +E+ R+R+ + + +L +L + T Q +E ++L Sbjct: 1753 EEEQGN-------MEAMSDRVRKATQQAE---QLSNELATERSTAQK-----NESARQQL 1797 Query: 3341 QKQLEEKHSRIVELLNETE---KYKLDSLQTR-QQMEKDRQVHRKTLQTEQEANTEGQKK 3396 ++Q +E S++ E+ + K + +L+ + Q+E+ + + Q ++ + KK Sbjct: 1798 ERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKK 1857 Query: 3397 MHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELEREEKRESRRILYQNL 3456 + E+ +VED ++ E+ ++Q K R++ + ++ ++ E E + +RR L + L Sbjct: 1858 LKEILLQVEDERKMAEQYKEQAEK---GNARVKQLKRQLEEAEEESQRINANRRKLQREL 1914 Query: 3457 NEPTTWSLTSDRTRNWVLQQKIEG 3480 +E T + R N L+ K+ G Sbjct: 1915 DEATESNEAMGREVN-ALKSKLRG 1937 Score = 135 bits (339), Expect = 1e-30 Identities = 239/1142 (20%), Positives = 497/1142 (43%), Gaps = 115/1142 (10%) Query: 1976 LSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVS 2035 ++RQ+E M+A+ E +L + E+ K + E++ + E+ L ++ L+ ++ + Sbjct: 854 VTRQEEEMQAK----EDELQKTKERQQKAENELK-ELEQKHSQLTEEKNLLQEQLQAETE 908 Query: 2036 RFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDR----EHERDVFQQEIQKLE 2091 + E E+ + + L + Q LE+ L +M L+E+ DR + ER Q++ LE Sbjct: 909 LYAEAEEMR----VRLAAKKQELEEILHEMEARLEEEE-DRGQQLQAERKKMAQQMLDLE 963 Query: 2092 QQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEF 2151 +QL+ + + Q ++E++ K K + E+L+ +Q + +ER + LE Sbjct: 964 EQLE-----EEEAARQKLQLEKVTAEAKIKKLE-DEILVMDDQNNKLSKER----KLLEE 1013 Query: 2152 RVRELEQALLVEDRKHFGAVEAKPE-----LSLEVQLQAERDAIDRKEKEITNLEEQLEQ 2206 R+ +L L E+ K + K + LEV+L+ E + EK LE Sbjct: 1014 RISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASD 1073 Query: 2207 FREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQ 2266 F E++ + ++ +L MQL +++E L L+ E + ++K I+E + + Sbjct: 1074 FHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKK----IRELEGHISD 1129 Query: 2267 DQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECL 2326 Q L + A + ++ + D L E++ L+ +L+ T D+ +++ R+ E + Sbjct: 1130 LQEDLDSERAARNKAEKQKRD-LGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKK 1188 Query: 2327 MSDQEC---------VKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLK 2377 D+E +++ + +E+L E +E+ ++ AN+ + N +L +E L Sbjct: 1189 ALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDK----NKQTLEKENADLA 1244 Query: 2378 HQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQS 2437 +L V+ K +E + + ++ +++ + +L ++ L+ E ESV + + Sbjct: 1245 GELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLN 1304 Query: 2438 IPE-NSVNVAID--HLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRL- 2493 E ++ +A D LS + + +L E+ + L T + EE L+ + Sbjct: 1305 EAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEME 1364 Query: 2494 --LQLESTVSAKDLELTQCYKQIKDMQ------EQGQFETEMLQKKIVNLQKIVEEKVAA 2545 LE +S +++L+ K+++D E+G+ + QK+I NL + EEK AA Sbjct: 1365 AKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGK---KRFQKEIENLTQQYEEKAAA 1421 Query: 2546 ALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELES 2605 +LE + + D+ + + +R + NL + + + +L + Sbjct: 1422 ----YDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQR------------KFDQLLA 1465 Query: 2606 QVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLK 2665 + + + E+++ AE EKE K L L + LE + + E E+ E+ Sbjct: 1466 EEKNISSKYADERDR---AEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEM-- 1520 Query: 2666 TTTELFHSNEESG-FFNELE----ALRAESVATKAELASYKEKAEKLQEELLVKETNMTS 2720 +L S ++ G +ELE AL + K +L +++ + ++ L E NM + Sbjct: 1521 --EDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQA 1578 Query: 2721 L----QKDLSQVRDHLAEAKEKLSILEKEDETEVQ-ESKKACMFEPLPIKLS---KSIAS 2772 L ++DL + E + +L E ETE++ E K+ + KL K + Sbjct: 1579 LKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLEL 1638 Query: 2773 QTDGTLK--ISSSNQTPQILVKNAGIQINLQSECSSEEVTEIISQFTEKIEKMQELHAAE 2830 Q D +K + Q ++ + Q L+ +S + EI + E +K + L A+ Sbjct: 1639 QADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRD--EIFATAKENEKKAKSLE-AD 1695 Query: 2831 ILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTR 2890 ++ ++ ++ E +++ + + L EE + + L+ ++ +A + Sbjct: 1696 LMQLQ-EDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEE 1754 Query: 2891 EICSSDSGSD-WGQGIYLTHSQGFDIASE-GRGEESESATDSFPKKIKGLLRAVHNEGMQ 2948 E + ++ SD + ++A+E +++ESA ++ K L +H Sbjct: 1755 EQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGA 1814 Query: 2949 VLSLTESPYS--DGEDHSIQQVSEPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQ 3006 V S +S + + + +++ E E++A ++ + ++ LQ E E + Q Sbjct: 1815 VKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQ 1874 Query: 3007 SHESFSDWRGEL-LLALQQVFLEERSVLLAAFRTEL-----TALGTTDAVGL-LNCLEQR 3059 E + L Q EE S + A R +L A + +A+G +N L+ + Sbjct: 1875 YKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSK 1934 Query: 3060 IQ 3061 ++ Sbjct: 1935 LR 1936 Score = 131 bits (329), Expect = 1e-29 Identities = 213/1071 (19%), Positives = 450/1071 (42%), Gaps = 162/1071 (15%) Query: 2 EDEERQKKLEAGKAKLAQFRQRKAQSDGQSPSKKQKKKRKTSSSKHDVSAHHDLNIDQSQ 61 E+E+R ++L+A + K+AQ + + + +QK + + +++ + D + Sbjct: 940 EEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDD 999 Query: 62 CNEMYINSSQRVESTVIPESTIMRTLHSGEITSHEQGFSVELESEISTTADDCSSEVNGC 121 N + +E + +T E + + ES IS E Sbjct: 1000 QNNKLSKERKLLEERISDLTT--NLAEEEEKAKNLTKLKNKHESMISELEVRLKKE---- 1053 Query: 122 SFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHEIEELNRELEEM 181 ++ + L+ + G + EQ A D + ++ +LA K+ E++ L++ Sbjct: 1054 ---EKSRQELEKLKRKLEGDASDFHEQIA-DLQAQIAELKMQLAKKEEELQAALARLDD- 1108 Query: 182 RVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQIQ 241 + L++++E E G I+ L +L R +++ ++ +L E+ + L+ + Sbjct: 1109 EIAQKNNALKKIRELE-------GHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTE 1161 Query: 242 F----------QQLQASE-----TLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLED 286 Q+L+A L+ + T + Q ++ H Q +EE LE Sbjct: 1162 LEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQ 1221 Query: 287 YQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEK----ETIIEELNTKIIEEE 342 +++ K + L+++ ++ + +V K+E++ K E ++EL +K + E Sbjct: 1222 FKRAKANLDKNKQTLEKENA--DLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGE 1279 Query: 343 KKTLELKDK-------LTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIK 395 + EL DK + + +L E + + ++ +++ ++ +L ++++ EE + Sbjct: 1280 RARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQE---LLQEETR 1336 Query: 396 QLMGTVEELQKRNHKDSQFETDIVQRME--QETQRKLEQLRAELDEMYGQQIVQMKQELI 453 Q + +L++ + + + + + ME Q +R + L +L + + K + Sbjct: 1337 QKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDS------KKKLQDF 1390 Query: 454 RQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQI-KLMNVAINELNIKLQDTNSQKEKL 512 + +EE K R + E+EN + Y D++ K N EL+ + D ++Q++ + Sbjct: 1391 ASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLV 1450 Query: 513 KEELGLILEEKCALQRQLEDLV-EELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDL 571 LE+K QR+ + L+ EE + S + + AE K K+LS L Sbjct: 1451 SN-----LEKK---QRKFDQLLAEEKNISSKYADERDRAEAEAREK---ETKALSLARAL 1499 Query: 572 KAEIVSASESRKELELKHEAEVTNYKIKLEM--LEKEKNAV------LDRMAESQEAELE 623 + + LE K E E TN +K EM L K+ V L++ + E ++E Sbjct: 1500 E----------EALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQME 1549 Query: 624 RLRTQLLFSHEEELSKLKEDLEIEHRINIEKLK----------DNLGIHYKQQIDGLQNE 673 ++TQL E+ + ED ++ +N++ LK D ++Q+ +E Sbjct: 1550 EMKTQL--EELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHE 1607 Query: 674 MSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSE------EMTLQINELQKE 727 ++E + ++ + +L ++ L+ S + + E ++ Q+ + Q+E Sbjct: 1608 YETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRE 1667 Query: 728 IEILR-----------QEEKEKGTLEQEVQELQ---LKTELLEKQMKEKENDLQEKFAQL 773 +E R + EK+ +LE ++ +LQ E KQ ++ +L E+ A Sbjct: 1668 LEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASS 1727 Query: 774 EAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLK 833 + + L+DEK+ LE + +EE + +E + + Sbjct: 1728 LSGRNALQDEKRRLEARIAQLEEELEEE-----------------QGNMEAMSDRVRKAT 1770 Query: 834 QQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKL 893 QQ QL+ E+ +R+T A+KN E Q+L+ + +++ L + + + ++KS + Sbjct: 1771 QQAEQLSNELATERST---AQKN-ESARQQLERQNK---ELRSKLHEMEGAVKSKFKSTI 1823 Query: 894 KAL-----------NEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELM 942 AL +E ++ ++K K E V + +M E ++ + Sbjct: 1824 AALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGN 1883 Query: 943 EKLEVTKR---EKLELSQRLSDLSEQLKQKHGEISFLNE----EVKSLKQE 986 +++ KR E E SQR++ +L+++ E + NE EV +LK + Sbjct: 1884 ARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSK 1934 Score = 129 bits (323), Expect = 7e-29 Identities = 272/1312 (20%), Positives = 541/1312 (41%), Gaps = 217/1312 (16%) Query: 414 FETDIVQRMEQETQRKLEQLRAELDEMYG------------QQIVQMKQELIRQHMAQME 461 F T ++ +E+E K+ + M QQ+ MK +I+++ A Sbjct: 777 FRTGVLAHLEEERDLKITDVIMAFQAMCRGYLARKAFAKRQQQLTAMK--VIQRNCAAYL 834 Query: 462 EMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILE 521 +++ + ++ +T E++++ + + + Q ++ ++L+++ + E Sbjct: 835 KLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTE 894 Query: 522 EKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVED----LKAEIVS 577 EK LQ QL+ E + + E R E E L+E L ED L+AE Sbjct: 895 EKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKK 954 Query: 578 ASESRKELELK-HEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEE 636 ++ +LE + E E K++LE + + EA++++L ++L ++ Sbjct: 955 MAQQMLDLEEQLEEEEAARQKLQLEKV-------------TAEAKIKKLEDEILVMDDQN 1001 Query: 637 LSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLI 696 KE +E RI+ L NL +++ L ++ K E+M E + + K+ + Sbjct: 1002 NKLSKERKLLEERIS--DLTTNLA-EEEEKAKNL-TKLKNKHESMISELEVRLKKEEKSR 1057 Query: 697 LEISKLKDLQQSLVNSKSEEMT-LQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELL 755 E+ KLK + + E++ LQ + ++++ ++EE+ + L + E+ K L Sbjct: 1058 QELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNAL 1117 Query: 756 EK--QMKEKENDLQEKF-AQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSK 812 +K +++ +DLQE ++ A N K ++ E++ + T + LDS ++ Sbjct: 1118 KKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDT-----LDSTATQ 1172 Query: 813 SK-DSVWEKEIEIL---IEEN--------EDLKQQCIQLNEEIEKQRNTFSFAEKNFEVN 860 + + E+E+ +L ++E ++++Q+ Q EE+ +Q F A+ N + N Sbjct: 1173 QELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKN 1232 Query: 861 YQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDED 920 Q L++E A L L + KQE+E+K K ++ +++S D + Sbjct: 1233 KQTLEKENADLAGELRVL--GQAKQEVEHKKK-----------KLEAQVQELQSKCSDGE 1279 Query: 921 KTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEV 980 + AE + ++ + + L + + ++L++ ++ LS QL+ L EE Sbjct: 1280 RA-RAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQ---ELLQEET 1335 Query: 981 KSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNK 1040 + +K VS + R+LE E S Q+ ++ + E +S +N Sbjct: 1336 R----QKLNVSTKLRQLE--------EERNSLQDQLDEEME-----AKQNLERHISTLNI 1378 Query: 1041 SFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELN 1100 + K + + + E + G++ Q++ + ++T++ +A + DKL+K N Sbjct: 1379 QLSDSKKKLQDFASTVEALEEGKKRFQKE-----IENLTQQYEEKA---AAYDKLEKTKN 1430 Query: 1101 VLKSEQNDLRLQMEAQRICLSLVYSTH--VDQVREYMENEKDKALCSLKEELIFAQEEKI 1158 L+ E +DL + ++ QR +S + DQ+ +N K A+E++ Sbjct: 1431 RLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKET 1490 Query: 1159 KELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPAL 1218 K L LE + ++ +E + K+ KA E Sbjct: 1491 KALSLARALE-EALEAKEELER-------TNKMLKAEME--------------------- 1521 Query: 1219 KCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEY----NKLLVLQ 1274 D +S D + +N EL+ + ++ E M T L ++ +E + L L+ Sbjct: 1522 -------DLVSSKDDVGKNVH-ELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLE 1573 Query: 1275 TRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKT 1334 + + GQ ++ E+N K +H T LED + K +L K Sbjct: 1574 VNMQALKGQFERDLQAR-DEQNEEKRRQLQRQLHEYETELED-----ERKQRALAAAAKK 1627 Query: 1335 KLEEQVQELE----SLISSLQQQLKETEQNYEAEIHCLQKRLQ------------AVSES 1378 KLE +++LE S I ++ +K+ + +A++ Q+ L+ A Sbjct: 1628 KLEGDLKDLELQADSAIKGREEAIKQL-RKLQAQMKDFQRELEDARASRDEIFATAKENE 1686 Query: 1379 TVPPSLPVDSVVITE--SDAQRTMYPGSCVKKNIDGTI--EFSGEFGVKEETNIVKLLEK 1434 SL D + + E + A+R K+ + + SG +++E ++ Sbjct: 1687 KKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIA 1746 Query: 1435 QYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMKLS 1494 Q +E+LEEE G E A S + QQ + NE L+ Sbjct: 1747 QLEEELEEE---------------------QGNME--AMSDRVRKATQQAEQLSNE--LA 1781 Query: 1495 QDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEMFS 1554 ++ Q E+ + + + K L +L E + E+K L E + Sbjct: 1782 TERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEA 1841 Query: 1555 KDKTFIVRQSIHDEISVSSMDAS-RQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHM 1613 ++K + S+ D ++++L Q+ED R ++ QY+E + A + Sbjct: 1842 REKQAATK-------SLKQKDKKLKEILL---QVEDER-KMAEQYKEQAEK----GNARV 1886 Query: 1614 RQMERQREDQEQLQEEIKRLNRQLAQRSSIDNE-NLVSERERVLLEELEALK 1664 +Q++RQ E+ E EE +R+N A R + E + +E + E+ ALK Sbjct: 1887 KQLKRQLEEAE---EESQRIN---ANRRKLQRELDEATESNEAMGREVNALK 1932 Score = 115 bits (289), Expect = 6e-25 Identities = 233/1163 (20%), Positives = 479/1163 (41%), Gaps = 196/1163 (16%) Query: 624 RLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQF 683 +++ L + +EE + KED ++K K+ +Q+ + E+ QK + Sbjct: 847 KVKPLLQVTRQEEEMQAKED-------ELQKTKER-----QQKAENELKELEQKHSQLTE 894 Query: 684 EKDNLITKQNQLILEI-SKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGT-L 741 EK NL+ +Q Q E+ ++ ++++ L K E + E+ E+E +EE+++G L Sbjct: 895 EK-NLLQEQLQAETELYAEAEEMRVRLAAKKQE-----LEEILHEMEARLEEEEDRGQQL 948 Query: 742 EQEVQELQLKTELLEKQMKEKE-----------------NDLQEKFAQLEAENSILKDEK 784 + E +++ + LE+Q++E+E L+++ ++ +N+ L E+ Sbjct: 949 QAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKER 1008 Query: 785 KTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIE 844 K LE+ + T EE + K K+K E+E+ +++ E +Q+ +L ++E Sbjct: 1009 KLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLE 1068 Query: 845 KQRNTFSFAEKNFEVNYQEL--------QEEYACLLKVKDDLEDSKN--KQELEYKSKLK 894 + F + + EL +E A L ++ D++ N K+ E + + Sbjct: 1069 GDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHIS 1128 Query: 895 ALNEELHLQRINPTTVKMKSSVFDED----KTFVAETLEMGEVVEKDTTELMEKLEVTKR 950 L E+L +R + + E+ KT + +TL+ ++ + +++ V K+ Sbjct: 1129 DLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKK 1188 Query: 951 EKLELSQRLSDLSEQLKQKHGE-ISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENV 1009 E ++ ++++QKH + + L E+++ K+ K + + LE EN Sbjct: 1189 ALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLE-------KENA 1241 Query: 1010 Q-SCDTQVSSLLDGVVTMTSRGAEGSVSKVNK--SFGEESKIMVEDKV--------SFEN 1058 + + +V V + E V ++ S GE ++ + DKV S Sbjct: 1242 DLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTG 1301 Query: 1059 MTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRI 1118 M E K +L D + S L+ TQ ++ +++LNV LR Q+E +R Sbjct: 1302 MLNEAEGKAIKLAKD---VASLSSQLQDTQELLQEETRQKLNV----STKLR-QLEEERN 1353 Query: 1119 CLSLVYSTHVDQVREYMENEK--DKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQE 1176 L DQ+ E ME ++ ++ + +L +L + K+LQ T E Sbjct: 1354 SLQ-------DQLDEEMEAKQNLERHISTLNIQL----SDSKKKLQDF-------ASTVE 1395 Query: 1177 TGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDK-ENSGDYIS 1235 +EGK + QK + E T + + A DK E + + + Sbjct: 1396 ALEEGKK------RFQKEI----------------ENLTQQYEEKAAAYDKLEKTKNRLQ 1433 Query: 1236 ENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEE 1295 + D + D D Q + + L K ++++LL + +S + + D + E E+ Sbjct: 1434 QELDDLVVDL-----DNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREK 1488 Query: 1296 -----NLPKEETEFLSIHSQM--------TNLEDIDVNHKSKLSSLQDLEKTK--LEEQV 1340 +L + E L ++ +ED+ + ++ +LEK+K LE Q+ Sbjct: 1489 ETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQM 1548 Query: 1341 QELESLISSLQQQLKETEQ-------NYEAEIHCLQKRLQAVSEST------VPPSLPVD 1387 +E+++ + L+ +L+ TE N +A ++ LQA E + L Sbjct: 1549 EEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEY 1608 Query: 1388 SVVITESDAQRTMYPGSCVKKNIDG---TIEFSGEFGVKEETNIVKLLE------KQYQE 1438 + + QR + + KK ++G +E + +K +K L K +Q Sbjct: 1609 ETELEDERKQRAL--AAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQR 1666 Query: 1439 QLEEEVAKVIVSMSIAFAQQTELSRISGG----KENTASSKQAHAVCQQEQHYFNEMKLS 1494 +LE+ A + A + + + +E+ A++++A E+ E +L+ Sbjct: 1667 ELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAE-ELA 1725 Query: 1495 QDQIGFQTFETVDVKFKEEFKPLSKEL-GEHGKEILLSNSDPHDIPESKDCVLTISEEMF 1553 G + + + L +EL E G +S+ +++ ++ E Sbjct: 1726 SSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERS 1785 Query: 1554 SKDKTFIVRQ-----------SIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQ 1602 + K RQ +H+ + E ++ + +++ ++ +E Q Sbjct: 1786 TAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQ 1845 Query: 1603 QATELLRQAHMR------QMERQREDQEQLQEE-------IKRLNRQLAQRSSIDNENLV 1649 AT+ L+Q + Q+E +R+ EQ +E+ +K+L RQL + + +++ + Sbjct: 1846 AATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQL-EEAEEESQRIN 1904 Query: 1650 SERERVLLEELEALKQLSLAGRE 1672 + R ++ E EA + GRE Sbjct: 1905 ANRRKLQRELDEATESNEAMGRE 1927 Score = 104 bits (260), Expect = 1e-21 Identities = 238/1165 (20%), Positives = 483/1165 (41%), Gaps = 170/1165 (14%) Query: 2124 KCSELLLSKEQLQRD----IQERNEEIEKLEFRVRELEQALLVEDRKHFGAVEAKPELSL 2179 K + L + + +QR+ ++ RN + +L +V+ L Q E+ E + Sbjct: 815 KRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKER 874 Query: 2180 EVQLQAERDAIDRKEKEITN----LEEQL----------EQFREELENKNEEVQQLHMQL 2225 + + + E +++K ++T L+EQL E+ R L K +E++++ ++ Sbjct: 875 QQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEM 934 Query: 2226 EIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVE 2285 E + +E R Q+L+ E K M L ++E +A + Q A+ I++ E E Sbjct: 935 EARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAK-IKKLEDE 993 Query: 2286 IDQLNEQVTKLQQQLK--------ITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNR 2337 I +++Q KL ++ K +TT+ EEK + + L+ + E ++S+ E + Sbjct: 994 ILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKE 1053 Query: 2338 EEEIEQLNEVIEKLQQELANIGQKTS----------MNAHSLSEEADSLKHQLDVVIAEK 2387 E+ ++L ++ KL+ + ++ ++ + M EE + +LD IA+K Sbjct: 1054 EKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQK 1113 Query: 2388 -------LALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESV-------E 2433 LE + E++ + + + L +EL +LK E E + Sbjct: 1114 NNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQ 1173 Query: 2434 KIQSIPENSVNVAIDHLSKDKPELEVVLTE------DALKSLENQ-TYFKSFEENGKGSI 2486 ++++ E V V L ++ E + E A++ L Q FK + N + Sbjct: 1174 ELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNK 1233 Query: 2487 INLETR----------LLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQ 2536 LE L Q + V K +L ++++ G+ L K+ LQ Sbjct: 1234 QTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQ 1293 Query: 2537 KIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISAL 2596 VE V+ + EA + K +D ++SS+ +Q+ +L ++E ++ Sbjct: 1294 NEVES------VTGMLNEAEGKAIKLAKDVASLSSQ-----LQDTQELLQEETRQKLNVS 1342 Query: 2597 TLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLE--GNEKKQREKEK 2654 T ++ +LE + + L E E + E+++ +L + +K L+ + + E+ K Sbjct: 1343 T-KLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGK 1401 Query: 2655 KRSPQDVEVLKTTTELFHSNEESGFFNELEALR----------AESVATKAELASYKEKA 2704 KR +++E L E E++ +++LE + + + +L S EK Sbjct: 1402 KRFQKEIENLTQQYE-----EKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKK 1456 Query: 2705 EKLQEELLVKETNMTSLQKDLSQVRDHL-AEAKEK----LSILEKEDETEVQESKKACMF 2759 ++ ++LL +E N++S D RD AEA+EK LS+ +E + + Sbjct: 1457 QRKFDQLLAEEKNISSKYAD---ERDRAEAEAREKETKALSLARALEEALEAKEELERTN 1513 Query: 2760 EPLPIKLSKSIASQTD---GTLKISSSNQTPQILVKNAGIQI-NLQSECSSEEVTEIISQ 2815 + L ++ ++S+ D ++ S + + ++ Q+ L+ E + E ++ + Sbjct: 1514 KMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLE 1573 Query: 2816 FTEKIEKMQ---ELHAAEILDMESR---------HISETETLKREHYVAVQLLKEECGTL 2863 + K Q +L A + + E R + +E E +++ +A K+ G L Sbjct: 1574 VNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDL 1633 Query: 2864 KAV-IQCLRSKEG--SSIPELAHSDAYQ---TREICSSDSGSDWGQGIYLTHSQGFDIAS 2917 K + +Q + +G +I +L A RE+ + + D I+ T + + Sbjct: 1634 KDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRD---EIFATAKE-----N 1685 Query: 2918 EGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERK 2977 E + + E+ + + RA ++ L E S + Q + LE R Sbjct: 1686 EKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARI 1745 Query: 2978 AYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAF 3037 A Q E E+ + + E+ SD + A QQ E+ S LA Sbjct: 1746 A-----------------QLEEELEEEQGNMEAMSD---RVRKATQQA--EQLSNELATE 1783 Query: 3038 RTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRK 3097 R+ TA A Q+++ Q E ++ + ++ A + S I AL A++ Sbjct: 1784 RS--TAQKNESA-------RQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKI---- 1830 Query: 3098 ITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELK 3157 L+ + E E ++ +++QK ++ E+ +++ + A + +EQ V +LK Sbjct: 1831 AQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLK 1890 Query: 3158 SELAQTKLELETTLKAQHKHLKELE 3182 +L + + E + + K +EL+ Sbjct: 1891 RQLEEAEEESQRINANRRKLQRELD 1915 Score = 82.8 bits (203), Expect = 6e-15 Identities = 170/823 (20%), Positives = 351/823 (42%), Gaps = 127/823 (15%) Query: 2923 ESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINT 2982 ++E+ + ++++ L A E ++L E+ + ED Q +E RK Sbjct: 904 QAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAE-----RKKMAQQ 958 Query: 2983 ISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELL--------LALQQVFLEERSVLL 3034 + L++ + + + R+ + + E+L L+ ++ LEER L Sbjct: 959 MLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDL 1018 Query: 3035 AAFRTE-------LTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQK--ADRRSLLSE 3085 E LT L +++ LE R++++ Q + +K D + Sbjct: 1019 TTNLAEEEEKAKNLTKLKNKHE-SMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQ 1077 Query: 3086 IQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQ 3145 I L AQ+ K+ L +++E + + L+ I QK + + +++ ++ ++LQE Sbjct: 1078 IADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIR----ELEGHISDLQED 1133 Query: 3146 LSSEKMV-------VAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLL 3198 L SE+ +L EL K ELE TL + +EL A R + EV +L Sbjct: 1134 LDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQ-QELRAKREQ------EVTVL 1186 Query: 3199 NDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLK---FSLESQKQRNLQLNLLL 3255 L E+ +S E Q +++ + K ++ E E+LE K +L+ KQ + N L Sbjct: 1187 KKAL-DEETRSHEAQ--VQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADL 1243 Query: 3256 EQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELH 3315 + ++L +++Q++E ++ +AQ+ E Q + + E+ R + D+ +L Sbjct: 1244 AGELRVLGQAKQEVEHKKKKLEAQVQELQSK------CSDGERAR----AELNDKVHKLQ 1293 Query: 3316 AQLQSSDGT---GQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQM 3372 +++S G + + ++D+ L QL++ ELL E + KL+ +Q+ Sbjct: 1294 NEVESVTGMLNEAEGKAIKLAKDVAS-LSSQLQDTQ----ELLQEETRQKLNVSTKLRQL 1348 Query: 3373 EKDRQVHRKTLQTEQEAN--------------TEGQKKMHE--------------LQSKV 3404 E++R + L E EA ++ +KK+ + Q ++ Sbjct: 1349 EEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEI 1408 Query: 3405 EDLQRQLEEKRQQVYKLDLEGQRLQGIMQEF------QKQELEREEKRESR--RILYQNL 3456 E+L +Q EEK KL+ RLQ + + Q+Q + EK++ + ++L + Sbjct: 1409 ENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEK 1468 Query: 3457 NEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELE----MIRQKLQ 3512 N + ++ DR + E ETK + A+ +E ELE M++ +++ Sbjct: 1469 NISSKYADERDRAE----AEAREKETKALSLARALE---EALEAKEELERTNKMLKAEME 1521 Query: 3513 CVASKLQVLPQKASERLQFETADDEDFIWVQENIDEIILQLQKLTGQ-QGEEPSLVSPST 3571 + S + + E + + A ++ ++E+ QL++L + Q E + + Sbjct: 1522 DLVSSKDDVGKNVHELEKSKRA-------LETQMEEMKTQLEELEDELQATEDAKLRLEV 1574 Query: 3572 SCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRFSLN 3631 + +L + R +L Q E++ L+ + + E ++ R+ A +++ L Sbjct: 1575 NMQALKGQFER---DLQARDEQNEEKRRQLQRQLHEYETELEDERKQRA-LAAAAKKKLE 1630 Query: 3632 GGANIEAIIASEKEVWNREKLTLQKSLKRAEAEVYKLKAELRN 3674 G + + ++ + RE+ K L++ +A++ + EL + Sbjct: 1631 GDLK-DLELQADSAIKGREEAI--KQLRKLQAQMKDFQRELED 1670 Score = 76.3 bits (186), Expect = 6e-13 Identities = 119/577 (20%), Positives = 241/577 (41%), Gaps = 64/577 (11%) Query: 3153 VAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQK---KS 3209 V + E+ + EL+ T + Q K EL+ + T+E +LL + L +E + ++ Sbjct: 854 VTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEA 913 Query: 3210 RELQWALEKEKAKLGR---SEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQ 3266 E++ L +K +L E EE ED L++++++ Q L LE+Q + ++ Sbjct: 914 EEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAAR 973 Query: 3267 QKIESQRMLYDAQLS---------EEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQ 3317 QK++ +++ +A++ ++Q L + L E RI ++++ L E E Sbjct: 974 QKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEE--RISDLTTNLAEEEEKAKN 1031 Query: 3318 LQSSDGTGQS---------RPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQT 3368 L +S + S L++L+++LE S E + + + + Sbjct: 1032 LTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQ 1091 Query: 3369 RQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLE---- 3424 + E++ Q L E KK+ EL+ + DLQ L+ +R K + + Sbjct: 1092 LAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDL 1151 Query: 3425 GQRLQGIMQEFQ--------KQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQ 3476 G+ L+ + E + +QEL R ++ + +L + L+E T + Q Sbjct: 1152 GEELEALKTELEDTLDSTATQQEL-RAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQ 1210 Query: 3477 KIEGETKESNYAKLIEMN---------GGGTGCNHELEMIRQKLQCVASKLQVLPQKASE 3527 +E T++ K + N EL ++ Q Q V K + L + E Sbjct: 1211 AVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQE 1270 Query: 3528 RLQFETADDEDF-IWVQENIDEIILQLQKLTGQQGE-EPSLVSPSTSCGSLTERL----- 3580 LQ + +D E + + + ++ +++ +TG E E + + SL+ +L Sbjct: 1271 -LQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQE 1329 Query: 3581 -----LRQNAELTGHISQLTEEKNDLRNMV---MKLEEQIRWYRQTGAGRDNSSRFSLNG 3632 RQ ++ + QL EE+N L++ + M+ ++ + + T + + S+ L Sbjct: 1330 LLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQD 1389 Query: 3633 GANIEAIIASEKEVWNREKLTLQKSLKRAEAEVYKLK 3669 A+ + K+ + +E L + + A KL+ Sbjct: 1390 FASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLE 1426 Score = 71.6 bits (174), Expect = 1e-11 Identities = 92/466 (19%), Positives = 200/466 (42%), Gaps = 52/466 (11%) Query: 3173 AQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKE 3232 A + L+ + +RL K K LL T E+ +++E + KE+ + +E ++ E Sbjct: 831 AAYLKLRNWQWWRLFTKVKP----LLQVTRQEEEMQAKEDELQKTKERQQKAENELKELE 886 Query: 3233 E----LEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNL 3288 + L + K L+ Q Q +L E+ + L +Q++E +A+L EE+ R Sbjct: 887 QKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQ 946 Query: 3289 ELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDL---------LKE 3339 +LQ + ++ ++ L+ E +LQ T +++ +++ L + Sbjct: 947 QLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSK 1006 Query: 3340 LQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHE 3399 +K LEE+ S + L E E+ + + + + E L+ E+++ E +K + Sbjct: 1007 ERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRK 1066 Query: 3400 LQSKVEDLQRQLEEKRQQVYKLDLE----GQRLQGIMQEFQKQELEREEKRESRRILYQN 3455 L+ D Q+ + + Q+ +L ++ + LQ + + ++ + R L + Sbjct: 1067 LEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGH 1126 Query: 3456 LNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMIRQKLQ--- 3512 +++ LQ+ ++ E N A+ + + G ELE ++ +L+ Sbjct: 1127 ISD---------------LQEDLDSERAARNKAEKQKRDLG-----EELEALKTELEDTL 1166 Query: 3513 -CVASKLQVLPQKASERLQFETADDEDF----IWVQENIDEIILQLQKLTGQQGEEPSLV 3567 A++ ++ ++ E + A DE+ VQE + +++LT Q + Sbjct: 1167 DSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQ---FK 1223 Query: 3568 SPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKLEEQIR 3613 + + L ++NA+L G + L + K ++ + KLE Q++ Sbjct: 1224 RAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQ 1269 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.309 0.126 0.326 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 130,787,658 Number of Sequences: 37866 Number of extensions: 6226864 Number of successful extensions: 116403 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 726 Number of HSP's successfully gapped in prelim test: 1741 Number of HSP's that attempted gapping in prelim test: 28916 Number of HSP's gapped (non-prelim): 35826 length of query: 3899 length of database: 18,247,518 effective HSP length: 122 effective length of query: 3777 effective length of database: 13,627,866 effective search space: 51472449882 effective search space used: 51472449882 T: 11 A: 40 X1: 16 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 42 (21.7 bits) S2: 72 (32.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.