Guide to the Human Genome
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Search of human proteins with 224926830

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|224926830 SH2B adaptor protein 1 isoform 3 [Homo sapiens]
         (683 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|224926830 SH2B adaptor protein 1 isoform 3 [Homo sapiens]         1386   0.0  
gi|224926824 SH2B adaptor protein 1 isoform 2 [Homo sapiens]         1290   0.0  
gi|224926828 SH2B adaptor protein 1 isoform 2 [Homo sapiens]         1290   0.0  
gi|224926822 SH2B adaptor protein 1 isoform 2 [Homo sapiens]         1290   0.0  
gi|224926826 SH2B adaptor protein 1 isoform 1 [Homo sapiens]         1283   0.0  
gi|242247193 SH2B adaptor protein 2 [Homo sapiens]                    368   e-101
gi|4885455 SH2B adaptor protein 3 [Homo sapiens]                      162   1e-39
gi|194239668 SHC (Src homology 2 domain containing) transforming...    63   1e-09
gi|194239664 SHC (Src homology 2 domain containing) transforming...    63   1e-09
gi|194239662 SHC (Src homology 2 domain containing) transforming...    63   1e-09
gi|32261324 SHC (Src homology 2 domain containing) transforming ...    63   1e-09
gi|187475373 c-src tyrosine kinase [Homo sapiens]                      57   4e-08
gi|4758078 c-src tyrosine kinase [Homo sapiens]                        57   4e-08
gi|239751592 PREDICTED: hypothetical protein XP_002347924 [Homo ...    57   6e-08
gi|169790811 SHC (Src homology 2 domain containing) transforming...    57   6e-08
gi|224586793 src homology 2 domain-containing transforming prote...    54   4e-07
gi|205277435 spleen tyrosine kinase isoform 2 [Homo sapiens]           54   4e-07
gi|21450844 megakaryocyte-associated tyrosine kinase isoform c [...    53   8e-07
gi|21450842 megakaryocyte-associated tyrosine kinase isoform b [...    53   8e-07
gi|21450846 megakaryocyte-associated tyrosine kinase isoform a [...    53   8e-07
gi|5453754 NCK adaptor protein 1 [Homo sapiens]                        52   1e-06
gi|222446609 rai-like protein [Homo sapiens]                           52   2e-06
gi|21361553 spleen tyrosine kinase isoform 1 [Homo sapiens]            51   3e-06
gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapi...    51   3e-06
gi|4506431 RAS p21 protein activator 1 isoform 1 [Homo sapiens]        51   3e-06
gi|12545406 RAS p21 protein activator 1 isoform 2 [Homo sapiens]       51   3e-06
gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo sapi...    51   4e-06
gi|117320537 phospholipase C, gamma 2 [Homo sapiens]                   50   5e-06
gi|41281821 SH2 domain containing 3C isoform a [Homo sapiens]          50   7e-06
gi|33598948 phospholipase C, gamma 1 isoform a [Homo sapiens]          49   2e-05

>gi|224926830 SH2B adaptor protein 1 isoform 3 [Homo sapiens]
          Length = 683

 Score = 1386 bits (3587), Expect = 0.0
 Identities = 683/683 (100%), Positives = 683/683 (100%)

Query: 1   MNGAPSPEDGASPSSPPLPPPPPPSWREFCESHARAAALDFARRFRLYLASHPQYAGPGA 60
           MNGAPSPEDGASPSSPPLPPPPPPSWREFCESHARAAALDFARRFRLYLASHPQYAGPGA
Sbjct: 1   MNGAPSPEDGASPSSPPLPPPPPPSWREFCESHARAAALDFARRFRLYLASHPQYAGPGA 60

Query: 61  EAAFSRRFAELFLQHFEAEVARASGSLSPPILAPLSPGAEISPHDLSLESCRVGGPLAVL 120
           EAAFSRRFAELFLQHFEAEVARASGSLSPPILAPLSPGAEISPHDLSLESCRVGGPLAVL
Sbjct: 61  EAAFSRRFAELFLQHFEAEVARASGSLSPPILAPLSPGAEISPHDLSLESCRVGGPLAVL 120

Query: 121 GPSRSSEDLAGPLPSSVSSSSTTSSKPKLKKRFSLRSVGRSVRGSVRGILQWRGTVDPPS 180
           GPSRSSEDLAGPLPSSVSSSSTTSSKPKLKKRFSLRSVGRSVRGSVRGILQWRGTVDPPS
Sbjct: 121 GPSRSSEDLAGPLPSSVSSSSTTSSKPKLKKRFSLRSVGRSVRGSVRGILQWRGTVDPPS 180

Query: 181 SAGPLETSSGPPVLGGNSNSNSSGGAGTVGRGLVSDGTSPGERWTHRFERLRLSRGGGAL 240
           SAGPLETSSGPPVLGGNSNSNSSGGAGTVGRGLVSDGTSPGERWTHRFERLRLSRGGGAL
Sbjct: 181 SAGPLETSSGPPVLGGNSNSNSSGGAGTVGRGLVSDGTSPGERWTHRFERLRLSRGGGAL 240

Query: 241 KDGAGMVQREELLSFMGAEEAAPDPAGVGRGGGVAGPPSGGGGQPQWQKCRLLLRSEGEG 300
           KDGAGMVQREELLSFMGAEEAAPDPAGVGRGGGVAGPPSGGGGQPQWQKCRLLLRSEGEG
Sbjct: 241 KDGAGMVQREELLSFMGAEEAAPDPAGVGRGGGVAGPPSGGGGQPQWQKCRLLLRSEGEG 300

Query: 301 GGGSRLEFFVPPKASRPRLSIPCSSITDVRTTTALEMPDRENTFVVKVEGPSEYIMETVD 360
           GGGSRLEFFVPPKASRPRLSIPCSSITDVRTTTALEMPDRENTFVVKVEGPSEYIMETVD
Sbjct: 301 GGGSRLEFFVPPKASRPRLSIPCSSITDVRTTTALEMPDRENTFVVKVEGPSEYIMETVD 360

Query: 361 AQHVKAWVSDIQECLSPGPCPATSPRPMTLPLAPGTSFLTRENTDSLELSCLNHSESLPS 420
           AQHVKAWVSDIQECLSPGPCPATSPRPMTLPLAPGTSFLTRENTDSLELSCLNHSESLPS
Sbjct: 361 AQHVKAWVSDIQECLSPGPCPATSPRPMTLPLAPGTSFLTRENTDSLELSCLNHSESLPS 420

Query: 421 QDLLLGPSESNDRLSQGAYGGLSDRPSASISPSSASIAASHFDSMELLPPELPPRIPIEE 480
           QDLLLGPSESNDRLSQGAYGGLSDRPSASISPSSASIAASHFDSMELLPPELPPRIPIEE
Sbjct: 421 QDLLLGPSESNDRLSQGAYGGLSDRPSASISPSSASIAASHFDSMELLPPELPPRIPIEE 480

Query: 481 GPPTGTVHPLSAPYPPLDTPETATGSFLFQGEPEGGEGDQPLSGYPWFHGMLSRLKAAQL 540
           GPPTGTVHPLSAPYPPLDTPETATGSFLFQGEPEGGEGDQPLSGYPWFHGMLSRLKAAQL
Sbjct: 481 GPPTGTVHPLSAPYPPLDTPETATGSFLFQGEPEGGEGDQPLSGYPWFHGMLSRLKAAQL 540

Query: 541 VLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQCRVQHLWFQSIFDM 600
           VLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQCRVQHLWFQSIFDM
Sbjct: 541 VLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQCRVQHLWFQSIFDM 600

Query: 601 LEHFRVHPIPLESGGSSDVVLVSYVPSSQRQQGEQSRSAGEEVPVHPRSEAGSRLGAMRG 660
           LEHFRVHPIPLESGGSSDVVLVSYVPSSQRQQGEQSRSAGEEVPVHPRSEAGSRLGAMRG
Sbjct: 601 LEHFRVHPIPLESGGSSDVVLVSYVPSSQRQQGEQSRSAGEEVPVHPRSEAGSRLGAMRG 660

Query: 661 CAREMDATPMPPAPSCPSERVTV 683
           CAREMDATPMPPAPSCPSERVTV
Sbjct: 661 CAREMDATPMPPAPSCPSERVTV 683


>gi|224926824 SH2B adaptor protein 1 isoform 2 [Homo sapiens]
          Length = 671

 Score = 1290 bits (3337), Expect = 0.0
 Identities = 643/673 (95%), Positives = 645/673 (95%), Gaps = 16/673 (2%)

Query: 1   MNGAPSPEDGASPSSPPLPPPPPPSWREFCESHARAAALDFARRFRLYLASHPQYAGPGA 60
           MNGAPSPEDGASPSSPPLPPPPPPSWREFCESHARAAALDFARRFRLYLASHPQYAGPGA
Sbjct: 1   MNGAPSPEDGASPSSPPLPPPPPPSWREFCESHARAAALDFARRFRLYLASHPQYAGPGA 60

Query: 61  EAAFSRRFAELFLQHFEAEVARASGSLSPPILAPLSPGAEISPHDLSLESCRVGGPLAVL 120
           EAAFSRRFAELFLQHFEAEVARASGSLSPPILAPLSPGAEISPHDLSLESCRVGGPLAVL
Sbjct: 61  EAAFSRRFAELFLQHFEAEVARASGSLSPPILAPLSPGAEISPHDLSLESCRVGGPLAVL 120

Query: 121 GPSRSSEDLAGPLPSSVSSSSTTSSKPKLKKRFSLRSVGRSVRGSVRGILQWRGTVDPPS 180
           GPSRSSEDLAGPLPSSVSSSSTTSSKPKLKKRFSLRSVGRSVRGSVRGILQWRGTVDPPS
Sbjct: 121 GPSRSSEDLAGPLPSSVSSSSTTSSKPKLKKRFSLRSVGRSVRGSVRGILQWRGTVDPPS 180

Query: 181 SAGPLETSSGPPVLGGNSNSNSSGGAGTVGRGLVSDGTSPGERWTHRFERLRLSRGGGAL 240
           SAGPLETSSGPPVLGGNSNSNSSGGAGTVGRGLVSDGTSPGERWTHRFERLRLSRGGGAL
Sbjct: 181 SAGPLETSSGPPVLGGNSNSNSSGGAGTVGRGLVSDGTSPGERWTHRFERLRLSRGGGAL 240

Query: 241 KDGAGMVQREELLSFMGAEEAAPDPAGVGRGGGVAGPPSGGGGQPQWQKCRLLLRSEGEG 300
           KDGAGMVQREELLSFMGAEEAAPDPAGVGRGGGVAGPPSGGGGQPQWQKCRLLLRSEGEG
Sbjct: 241 KDGAGMVQREELLSFMGAEEAAPDPAGVGRGGGVAGPPSGGGGQPQWQKCRLLLRSEGEG 300

Query: 301 GGGSRLEFFVPPKASRPRLSIPCSSITDVRTTTALEMPDRENTFVVKVEGPSEYIMETVD 360
           GGGSRLEFFVPPKASRPRLSIPCSSITDVRTTTALEMPDRENTFVVKVEGPSEYIMETVD
Sbjct: 301 GGGSRLEFFVPPKASRPRLSIPCSSITDVRTTTALEMPDRENTFVVKVEGPSEYIMETVD 360

Query: 361 AQHVKAWVSDIQECLSPGPCPATSPRPMTLPLAPGTSFLTRENTDSLELSCLNHSESLPS 420
           AQHVKAWVSDIQECLSPGPCPATSPRPMTLPLAPGTSFLTRENTDSLELSCLNHSESLPS
Sbjct: 361 AQHVKAWVSDIQECLSPGPCPATSPRPMTLPLAPGTSFLTRENTDSLELSCLNHSESLPS 420

Query: 421 QDLLLGPSESNDRLSQGAYGGLSDRPSASISPSSASIAASHFDSMELLPPELPPRIPIEE 480
           QDLLLGPSESNDRLSQGAYGGLSDRPSASISPSSASIAASHFDSMELLPPELPPRIPIEE
Sbjct: 421 QDLLLGPSESNDRLSQGAYGGLSDRPSASISPSSASIAASHFDSMELLPPELPPRIPIEE 480

Query: 481 GPPTGTVHPLSAPYPPLDTPETATGSFLFQGEPEGGEGDQPLSGYPWFHGMLSRLKAAQL 540
           GPPTGTVHPLSAPYPPLDTPETATGSFLFQGEPEGGEGDQPLSGYPWFHGMLSRLKAAQL
Sbjct: 481 GPPTGTVHPLSAPYPPLDTPETATGSFLFQGEPEGGEGDQPLSGYPWFHGMLSRLKAAQL 540

Query: 541 VLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQCRVQHLWFQSIFDM 600
           VLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQCRVQHLWFQSIFDM
Sbjct: 541 VLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQCRVQHLWFQSIFDM 600

Query: 601 LEHFRVHPIPLESGGSSDVVLVSYVPSSQRQQGEQSRSAGEEVPVHPRSEAGSRLGAMR- 659
           LEHFRVHPIPLESGGSSDVVLVSYVPSSQRQQG              R +AGS  G    
Sbjct: 601 LEHFRVHPIPLESGGSSDVVLVSYVPSSQRQQG--------------REQAGSHAGVCEG 646

Query: 660 -GCAREMDATPMP 671
            GC  +   T MP
Sbjct: 647 DGCHPDASCTLMP 659


>gi|224926828 SH2B adaptor protein 1 isoform 2 [Homo sapiens]
          Length = 671

 Score = 1290 bits (3337), Expect = 0.0
 Identities = 643/673 (95%), Positives = 645/673 (95%), Gaps = 16/673 (2%)

Query: 1   MNGAPSPEDGASPSSPPLPPPPPPSWREFCESHARAAALDFARRFRLYLASHPQYAGPGA 60
           MNGAPSPEDGASPSSPPLPPPPPPSWREFCESHARAAALDFARRFRLYLASHPQYAGPGA
Sbjct: 1   MNGAPSPEDGASPSSPPLPPPPPPSWREFCESHARAAALDFARRFRLYLASHPQYAGPGA 60

Query: 61  EAAFSRRFAELFLQHFEAEVARASGSLSPPILAPLSPGAEISPHDLSLESCRVGGPLAVL 120
           EAAFSRRFAELFLQHFEAEVARASGSLSPPILAPLSPGAEISPHDLSLESCRVGGPLAVL
Sbjct: 61  EAAFSRRFAELFLQHFEAEVARASGSLSPPILAPLSPGAEISPHDLSLESCRVGGPLAVL 120

Query: 121 GPSRSSEDLAGPLPSSVSSSSTTSSKPKLKKRFSLRSVGRSVRGSVRGILQWRGTVDPPS 180
           GPSRSSEDLAGPLPSSVSSSSTTSSKPKLKKRFSLRSVGRSVRGSVRGILQWRGTVDPPS
Sbjct: 121 GPSRSSEDLAGPLPSSVSSSSTTSSKPKLKKRFSLRSVGRSVRGSVRGILQWRGTVDPPS 180

Query: 181 SAGPLETSSGPPVLGGNSNSNSSGGAGTVGRGLVSDGTSPGERWTHRFERLRLSRGGGAL 240
           SAGPLETSSGPPVLGGNSNSNSSGGAGTVGRGLVSDGTSPGERWTHRFERLRLSRGGGAL
Sbjct: 181 SAGPLETSSGPPVLGGNSNSNSSGGAGTVGRGLVSDGTSPGERWTHRFERLRLSRGGGAL 240

Query: 241 KDGAGMVQREELLSFMGAEEAAPDPAGVGRGGGVAGPPSGGGGQPQWQKCRLLLRSEGEG 300
           KDGAGMVQREELLSFMGAEEAAPDPAGVGRGGGVAGPPSGGGGQPQWQKCRLLLRSEGEG
Sbjct: 241 KDGAGMVQREELLSFMGAEEAAPDPAGVGRGGGVAGPPSGGGGQPQWQKCRLLLRSEGEG 300

Query: 301 GGGSRLEFFVPPKASRPRLSIPCSSITDVRTTTALEMPDRENTFVVKVEGPSEYIMETVD 360
           GGGSRLEFFVPPKASRPRLSIPCSSITDVRTTTALEMPDRENTFVVKVEGPSEYIMETVD
Sbjct: 301 GGGSRLEFFVPPKASRPRLSIPCSSITDVRTTTALEMPDRENTFVVKVEGPSEYIMETVD 360

Query: 361 AQHVKAWVSDIQECLSPGPCPATSPRPMTLPLAPGTSFLTRENTDSLELSCLNHSESLPS 420
           AQHVKAWVSDIQECLSPGPCPATSPRPMTLPLAPGTSFLTRENTDSLELSCLNHSESLPS
Sbjct: 361 AQHVKAWVSDIQECLSPGPCPATSPRPMTLPLAPGTSFLTRENTDSLELSCLNHSESLPS 420

Query: 421 QDLLLGPSESNDRLSQGAYGGLSDRPSASISPSSASIAASHFDSMELLPPELPPRIPIEE 480
           QDLLLGPSESNDRLSQGAYGGLSDRPSASISPSSASIAASHFDSMELLPPELPPRIPIEE
Sbjct: 421 QDLLLGPSESNDRLSQGAYGGLSDRPSASISPSSASIAASHFDSMELLPPELPPRIPIEE 480

Query: 481 GPPTGTVHPLSAPYPPLDTPETATGSFLFQGEPEGGEGDQPLSGYPWFHGMLSRLKAAQL 540
           GPPTGTVHPLSAPYPPLDTPETATGSFLFQGEPEGGEGDQPLSGYPWFHGMLSRLKAAQL
Sbjct: 481 GPPTGTVHPLSAPYPPLDTPETATGSFLFQGEPEGGEGDQPLSGYPWFHGMLSRLKAAQL 540

Query: 541 VLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQCRVQHLWFQSIFDM 600
           VLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQCRVQHLWFQSIFDM
Sbjct: 541 VLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQCRVQHLWFQSIFDM 600

Query: 601 LEHFRVHPIPLESGGSSDVVLVSYVPSSQRQQGEQSRSAGEEVPVHPRSEAGSRLGAMR- 659
           LEHFRVHPIPLESGGSSDVVLVSYVPSSQRQQG              R +AGS  G    
Sbjct: 601 LEHFRVHPIPLESGGSSDVVLVSYVPSSQRQQG--------------REQAGSHAGVCEG 646

Query: 660 -GCAREMDATPMP 671
            GC  +   T MP
Sbjct: 647 DGCHPDASCTLMP 659


>gi|224926822 SH2B adaptor protein 1 isoform 2 [Homo sapiens]
          Length = 671

 Score = 1290 bits (3337), Expect = 0.0
 Identities = 643/673 (95%), Positives = 645/673 (95%), Gaps = 16/673 (2%)

Query: 1   MNGAPSPEDGASPSSPPLPPPPPPSWREFCESHARAAALDFARRFRLYLASHPQYAGPGA 60
           MNGAPSPEDGASPSSPPLPPPPPPSWREFCESHARAAALDFARRFRLYLASHPQYAGPGA
Sbjct: 1   MNGAPSPEDGASPSSPPLPPPPPPSWREFCESHARAAALDFARRFRLYLASHPQYAGPGA 60

Query: 61  EAAFSRRFAELFLQHFEAEVARASGSLSPPILAPLSPGAEISPHDLSLESCRVGGPLAVL 120
           EAAFSRRFAELFLQHFEAEVARASGSLSPPILAPLSPGAEISPHDLSLESCRVGGPLAVL
Sbjct: 61  EAAFSRRFAELFLQHFEAEVARASGSLSPPILAPLSPGAEISPHDLSLESCRVGGPLAVL 120

Query: 121 GPSRSSEDLAGPLPSSVSSSSTTSSKPKLKKRFSLRSVGRSVRGSVRGILQWRGTVDPPS 180
           GPSRSSEDLAGPLPSSVSSSSTTSSKPKLKKRFSLRSVGRSVRGSVRGILQWRGTVDPPS
Sbjct: 121 GPSRSSEDLAGPLPSSVSSSSTTSSKPKLKKRFSLRSVGRSVRGSVRGILQWRGTVDPPS 180

Query: 181 SAGPLETSSGPPVLGGNSNSNSSGGAGTVGRGLVSDGTSPGERWTHRFERLRLSRGGGAL 240
           SAGPLETSSGPPVLGGNSNSNSSGGAGTVGRGLVSDGTSPGERWTHRFERLRLSRGGGAL
Sbjct: 181 SAGPLETSSGPPVLGGNSNSNSSGGAGTVGRGLVSDGTSPGERWTHRFERLRLSRGGGAL 240

Query: 241 KDGAGMVQREELLSFMGAEEAAPDPAGVGRGGGVAGPPSGGGGQPQWQKCRLLLRSEGEG 300
           KDGAGMVQREELLSFMGAEEAAPDPAGVGRGGGVAGPPSGGGGQPQWQKCRLLLRSEGEG
Sbjct: 241 KDGAGMVQREELLSFMGAEEAAPDPAGVGRGGGVAGPPSGGGGQPQWQKCRLLLRSEGEG 300

Query: 301 GGGSRLEFFVPPKASRPRLSIPCSSITDVRTTTALEMPDRENTFVVKVEGPSEYIMETVD 360
           GGGSRLEFFVPPKASRPRLSIPCSSITDVRTTTALEMPDRENTFVVKVEGPSEYIMETVD
Sbjct: 301 GGGSRLEFFVPPKASRPRLSIPCSSITDVRTTTALEMPDRENTFVVKVEGPSEYIMETVD 360

Query: 361 AQHVKAWVSDIQECLSPGPCPATSPRPMTLPLAPGTSFLTRENTDSLELSCLNHSESLPS 420
           AQHVKAWVSDIQECLSPGPCPATSPRPMTLPLAPGTSFLTRENTDSLELSCLNHSESLPS
Sbjct: 361 AQHVKAWVSDIQECLSPGPCPATSPRPMTLPLAPGTSFLTRENTDSLELSCLNHSESLPS 420

Query: 421 QDLLLGPSESNDRLSQGAYGGLSDRPSASISPSSASIAASHFDSMELLPPELPPRIPIEE 480
           QDLLLGPSESNDRLSQGAYGGLSDRPSASISPSSASIAASHFDSMELLPPELPPRIPIEE
Sbjct: 421 QDLLLGPSESNDRLSQGAYGGLSDRPSASISPSSASIAASHFDSMELLPPELPPRIPIEE 480

Query: 481 GPPTGTVHPLSAPYPPLDTPETATGSFLFQGEPEGGEGDQPLSGYPWFHGMLSRLKAAQL 540
           GPPTGTVHPLSAPYPPLDTPETATGSFLFQGEPEGGEGDQPLSGYPWFHGMLSRLKAAQL
Sbjct: 481 GPPTGTVHPLSAPYPPLDTPETATGSFLFQGEPEGGEGDQPLSGYPWFHGMLSRLKAAQL 540

Query: 541 VLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQCRVQHLWFQSIFDM 600
           VLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQCRVQHLWFQSIFDM
Sbjct: 541 VLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQCRVQHLWFQSIFDM 600

Query: 601 LEHFRVHPIPLESGGSSDVVLVSYVPSSQRQQGEQSRSAGEEVPVHPRSEAGSRLGAMR- 659
           LEHFRVHPIPLESGGSSDVVLVSYVPSSQRQQG              R +AGS  G    
Sbjct: 601 LEHFRVHPIPLESGGSSDVVLVSYVPSSQRQQG--------------REQAGSHAGVCEG 646

Query: 660 -GCAREMDATPMP 671
            GC  +   T MP
Sbjct: 647 DGCHPDASCTLMP 659


>gi|224926826 SH2B adaptor protein 1 isoform 1 [Homo sapiens]
          Length = 756

 Score = 1283 bits (3321), Expect = 0.0
 Identities = 637/649 (98%), Positives = 638/649 (98%), Gaps = 1/649 (0%)

Query: 1   MNGAPSPEDGASPSSPPLPPPPPPSWREFCESHARAAALDFARRFRLYLASHPQYAGPGA 60
           MNGAPSPEDGASPSSPPLPPPPPPSWREFCESHARAAALDFARRFRLYLASHPQYAGPGA
Sbjct: 1   MNGAPSPEDGASPSSPPLPPPPPPSWREFCESHARAAALDFARRFRLYLASHPQYAGPGA 60

Query: 61  EAAFSRRFAELFLQHFEAEVARASGSLSPPILAPLSPGAEISPHDLSLESCRVGGPLAVL 120
           EAAFSRRFAELFLQHFEAEVARASGSLSPPILAPLSPGAEISPHDLSLESCRVGGPLAVL
Sbjct: 61  EAAFSRRFAELFLQHFEAEVARASGSLSPPILAPLSPGAEISPHDLSLESCRVGGPLAVL 120

Query: 121 GPSRSSEDLAGPLPSSVSSSSTTSSKPKLKKRFSLRSVGRSVRGSVRGILQWRGTVDPPS 180
           GPSRSSEDLAGPLPSSVSSSSTTSSKPKLKKRFSLRSVGRSVRGSVRGILQWRGTVDPPS
Sbjct: 121 GPSRSSEDLAGPLPSSVSSSSTTSSKPKLKKRFSLRSVGRSVRGSVRGILQWRGTVDPPS 180

Query: 181 SAGPLETSSGPPVLGGNSNSNSSGGAGTVGRGLVSDGTSPGERWTHRFERLRLSRGGGAL 240
           SAGPLETSSGPPVLGGNSNSNSSGGAGTVGRGLVSDGTSPGERWTHRFERLRLSRGGGAL
Sbjct: 181 SAGPLETSSGPPVLGGNSNSNSSGGAGTVGRGLVSDGTSPGERWTHRFERLRLSRGGGAL 240

Query: 241 KDGAGMVQREELLSFMGAEEAAPDPAGVGRGGGVAGPPSGGGGQPQWQKCRLLLRSEGEG 300
           KDGAGMVQREELLSFMGAEEAAPDPAGVGRGGGVAGPPSGGGGQPQWQKCRLLLRSEGEG
Sbjct: 241 KDGAGMVQREELLSFMGAEEAAPDPAGVGRGGGVAGPPSGGGGQPQWQKCRLLLRSEGEG 300

Query: 301 GGGSRLEFFVPPKASRPRLSIPCSSITDVRTTTALEMPDRENTFVVKVEGPSEYIMETVD 360
           GGGSRLEFFVPPKASRPRLSIPCSSITDVRTTTALEMPDRENTFVVKVEGPSEYIMETVD
Sbjct: 301 GGGSRLEFFVPPKASRPRLSIPCSSITDVRTTTALEMPDRENTFVVKVEGPSEYIMETVD 360

Query: 361 AQHVKAWVSDIQECLSPGPCPATSPRPMTLPLAPGTSFLTRENTDSLELSCLNHSESLPS 420
           AQHVKAWVSDIQECLSPGPCPATSPRPMTLPLAPGTSFLTRENTDSLELSCLNHSESLPS
Sbjct: 361 AQHVKAWVSDIQECLSPGPCPATSPRPMTLPLAPGTSFLTRENTDSLELSCLNHSESLPS 420

Query: 421 QDLLLGPSESNDRLSQGAYGGLSDRPSASISPSSASIAASHFDSMELLPPELPPRIPIEE 480
           QDLLLGPSESNDRLSQGAYGGLSDRPSASISPSSASIAASHFDSMELLPPELPPRIPIEE
Sbjct: 421 QDLLLGPSESNDRLSQGAYGGLSDRPSASISPSSASIAASHFDSMELLPPELPPRIPIEE 480

Query: 481 GPPTGTVHPLSAPYPPLDTPETATGSFLFQGEPEGGEGDQPLSGYPWFHGMLSRLKAAQL 540
           GPPTGTVHPLSAPYPPLDTPETATGSFLFQGEPEGGEGDQPLSGYPWFHGMLSRLKAAQL
Sbjct: 481 GPPTGTVHPLSAPYPPLDTPETATGSFLFQGEPEGGEGDQPLSGYPWFHGMLSRLKAAQL 540

Query: 541 VLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQCRVQHLWFQSIFDM 600
           VLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQCRVQHLWFQSIFDM
Sbjct: 541 VLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQCRVQHLWFQSIFDM 600

Query: 601 LEHFRVHPIPLESGGSSDVVLVSYVPSSQRQQGEQSRSAGEEVPVHPRS 649
           LEHFRVHPIPLESGGSSDVVLVSYVPSSQRQQ E + S     P  P S
Sbjct: 601 LEHFRVHPIPLESGGSSDVVLVSYVPSSQRQQ-EPTTSHDPPQPPEPPS 648


>gi|242247193 SH2B adaptor protein 2 [Homo sapiens]
          Length = 675

 Score =  368 bits (944), Expect = e-101
 Identities = 255/626 (40%), Positives = 327/626 (52%), Gaps = 112/626 (17%)

Query: 1   MNGAPSPEDGASPSSPPLPPPPPPSWREFCESHARAAALDFARRFRLYLASHPQYAGPGA 60
           MNGA     G + ++P   P P P WR+FCE HA+AAA+DFA +F  +L  +P Y  P A
Sbjct: 44  MNGAGP---GPAAAAPVPVPVPVPDWRQFCELHAQAAAVDFAHKFCRFLRDNPAYDTPDA 100

Query: 61  EAAFSRRFAELFLQHFEAEVARASGSLSPPILAPLSPGAEISPHDLSLESCRVGG-PLAV 119
            A+FSR FA  FL  F  EV R        +  P + GA +S   +  E         A 
Sbjct: 101 GASFSRHFAANFLDVFGEEVRRVL------VAGPTTRGAAVSAEAMEPELADTSALKAAP 154

Query: 120 LGPSRSSEDLAGPLPSSVSSSSTTSSKPKLKKRFSLRSVGRSVRGSVRGILQWRGTVDPP 179
            G SRSSED+          S+  ++K +++K FSLR++   V   VR +   R + +P 
Sbjct: 155 YGHSRSSEDV----------STHAATKARVRKGFSLRNMSLCVVDGVRDMWHRRASPEPD 204

Query: 180 SSAGPLETSSGPPVLGGNSNSNSSGGAGTVGRGLVSDGTSPGERWTHRFERLRLSRGGGA 239
           ++A P                                   P ++WT R   LRLSR   A
Sbjct: 205 AAAAPRTAE-------------------------------PRDKWTRR---LRLSRTLAA 230

Query: 240 LKDGAGMVQREELLSFMGAEEAAPDPAGVGRGGGVAGPPSGGGGQPQWQKCRLLLRSEGE 299
             +    +QRE  L FM A++AA                +G GG  QWQKCRLLLR    
Sbjct: 231 KVELVD-IQREGALRFMVADDAA----------------AGSGGSAQWQKCRLLLR-RAV 272

Query: 300 GGGGSRLEFFVPPKASRPRLSIPCSSITDVRTTTALEMPDRENTFVVKVEGPSEYIMETV 359
                RLEFFVPPKASRP++SIP S+I +VRTT  LEMP+++NTFV+KVE  +EYI+ET+
Sbjct: 273 AEERFRLEFFVPPKASRPKVSIPLSAIIEVRTTMPLEMPEKDNTFVLKVENGAEYILETI 332

Query: 360 DAQHVKAWVSDIQECLSPGPCPATSPRPMTLPLAPGTSFLTRENTDSLELSCLNHSESLP 419
           D+    +WV+DIQ C+ PG     S     L    G    +R  + S EL  L  +  LP
Sbjct: 333 DSLQKHSWVADIQGCVDPGD----SEEDTELSCTRGGCLASRVASCSCEL--LTDAVDLP 386

Query: 420 SQDLLLGPSESNDRLSQGAYGGLSDRPSASISPSSASIAASHFDSMELLPPELPPRIPIE 479
                  P E+       A G              A + A H    + +   L   +P+E
Sbjct: 387 R------PPETT------AVG--------------AVVTAPHSRGRDAVRESLI-HVPLE 419

Query: 480 EGPPTGTVHPLSAPYPPLDTPETATGSFLFQGEPEGGEGDQPLSGYPWFHGMLSRLKAAQ 539
               T     L +P     +    TG    + +PE  E +  LS YPWFHG LSR+KAAQ
Sbjct: 420 TFLQT-----LESPGGS-GSDSNNTGEQGAETDPEA-EPELELSDYPWFHGTLSRVKAAQ 472

Query: 540 LVLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQCRVQHLWFQSIFD 599
           LVL GG  +HG+F++RQSETR GEYVLTFNFQGKAKHLRLSLN  GQC VQHLWFQS+ D
Sbjct: 473 LVLAGGPRNHGLFVIRQSETRPGEYVLTFNFQGKAKHLRLSLNGHGQCHVQHLWFQSVLD 532

Query: 600 MLEHFRVHPIPLESGGSSDVVLVSYV 625
           ML HF  HPIPLESGGS+D+ L SYV
Sbjct: 533 MLRHFHTHPIPLESGGSADITLRSYV 558


>gi|4885455 SH2B adaptor protein 3 [Homo sapiens]
          Length = 575

 Score =  162 bits (409), Expect = 1e-39
 Identities = 101/208 (48%), Positives = 118/208 (56%), Gaps = 15/208 (7%)

Query: 487 VHPLSAPYPPLDTPETATGSFLFQGEPEGG-------EGDQPLSGYPWFHGMLSRLKAAQ 539
           +H  SA  P   +    +   L QG   GG       + D  LS YPWFHG +SR+KAAQ
Sbjct: 317 MHIPSALEPSTSSSPRGSTDSLNQGASPGGLLDPACQKTDHFLSCYPWFHGPISRVKAAQ 376

Query: 540 LVLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQCRVQHLWFQSIFD 599
           LV   G  +HGVFLVRQSETRRGEYVLTFNFQG AKHLRLSL E GQCRVQHL F S+ D
Sbjct: 377 LVQLQGPDAHGVFLVRQSETRRGEYVLTFNFQGIAKHLRLSLTERGQCRVQHLHFPSVVD 436

Query: 600 MLEHFRVHPIPLESGGSSDVVLVSYVPSSQRQQGEQSRSAGEEVPVHPRSEA----GSRL 655
           ML HF+  PIPLE G + DV L SYV    +  G  +         H  SE+    GS L
Sbjct: 437 MLHHFQRSPIPLECGAACDVRLSSYVVVVSQPPGSCNTVLFPFSLPHWDSESLPHWGSEL 496

Query: 656 G----AMRGCAREMDATPMPPAPSCPSE 679
           G    +  GC R +    +P   S P +
Sbjct: 497 GLPHLSSSGCPRGLSPEGLPGRSSPPEQ 524



 Score =  131 bits (330), Expect = 2e-30
 Identities = 127/409 (31%), Positives = 177/409 (43%), Gaps = 91/409 (22%)

Query: 11  ASPSSPPLPPPP--PPSWREFCESHARAAALDFARRFRLYLASHPQYAGPGAEAAFSRRF 68
           +SPSS P   P   P  W EFCE HA AAA + AR++ L+   HPQ+A   AE   S +F
Sbjct: 9   SSPSSAPSASPAAAPRGWSEFCELHAVAAARELARQYWLFAREHPQHAPLRAELV-SLQF 67

Query: 69  AELFLQHFEAEV--ARASG------SLSPPILAPLSPGAEISPHDLSLESCRVGGPLAV- 119
            +LF ++F  EV   RA G         PP  A  SP  E  P           GP A  
Sbjct: 68  TDLFQRYFCREVRDGRAPGRDYRDTGRGPPAKAEASP--EPGP-----------GPAAPG 114

Query: 120 LGPSRSSEDLAGPLPSSVSSSSTTSSKPKLKKRFSLRSVGRSVRGSVRGILQWRGTVDPP 179
           L  +RSSE+LA P P    S                    +  R S+R I + R   + P
Sbjct: 115 LPKARSSEELAPPRPPGPCSF-------------------QHFRRSLRHIFRRRSAGELP 155

Query: 180 SSAGPLETSSGPPVLGGNSNSNSSGGAGTVGRGLVSDGTSPGERWTHRFERLRLSRGGGA 239
           ++     T++ P   G  + + +  G                     +F    L+R    
Sbjct: 156 AA----HTAAAPGTPGEAAETPARPGLAK------------------KFLPWSLAR---- 189

Query: 240 LKDGAGMVQREELLSFMGAEEAAPDPAGVGRGGGVAGPPSGGGGQPQWQKCRLLLR-SEG 298
             +      +E +L +  A+EA+ D                     +WQ+ RL LR + G
Sbjct: 190 --EPPPEALKEAVLRYSLADEASMDSGA------------------RWQRGRLALRRAPG 229

Query: 299 EGGGGSRLEFFVPPKASRPRLSIPCSSITDVRTTTALEMPDRENTFVVKVEGPSEYIMET 358
             G    LE F PPK+SRP+L   CSSI +VR  T LEMPD   TFV+KV+  ++ I E 
Sbjct: 230 PDGPDRVLELFDPPKSSRPKLQAACSSIQEVRWCTRLEMPDNLYTFVLKVKDRTDIIFEV 289

Query: 359 VDAQHVKAWVSDIQECLSPGPCPATSPRPMTLPLAPGTSFLTRENTDSL 407
            D Q + +W++++ EC   G     +   +   L P TS   R +TDSL
Sbjct: 290 GDEQQLNSWMAELSECTGRGLESTEAEMHIPSALEPSTSSSPRGSTDSL 338


>gi|194239668 SHC (Src homology 2 domain containing) transforming
           protein 1 isoform 4 [Homo sapiens]
          Length = 473

 Score = 62.8 bits (151), Expect = 1e-09
 Identities = 39/104 (37%), Positives = 57/104 (54%), Gaps = 6/104 (5%)

Query: 513 PEGGEGDQPLSGYPWFHGMLSRLKAAQLVLTGGTGSHGVFLVRQSETRRGEYVLTFNFQG 572
           P+     + L G PWFHG LSR +A  L+   G      FLVR+S T  G+YVLT    G
Sbjct: 364 PQSVSMAEQLRGEPWFHGKLSRREAEALLQLNGD-----FLVRESTTTPGQYVLTGLQSG 418

Query: 573 KAKHLRLSLNEEGQCRVQHLWFQSIFDMLEHFRVHPIPLESGGS 616
           + KHL L ++ EG  R +   F+S+  ++ +   + +P+ S GS
Sbjct: 419 QPKHL-LLVDPEGVVRTKDHRFESVSHLISYHMDNHLPIISAGS 461


>gi|194239664 SHC (Src homology 2 domain containing) transforming
           protein 1 isoform 3 [Homo sapiens]
          Length = 584

 Score = 62.8 bits (151), Expect = 1e-09
 Identities = 39/104 (37%), Positives = 57/104 (54%), Gaps = 6/104 (5%)

Query: 513 PEGGEGDQPLSGYPWFHGMLSRLKAAQLVLTGGTGSHGVFLVRQSETRRGEYVLTFNFQG 572
           P+     + L G PWFHG LSR +A  L+   G      FLVR+S T  G+YVLT    G
Sbjct: 475 PQSVSMAEQLRGEPWFHGKLSRREAEALLQLNGD-----FLVRESTTTPGQYVLTGLQSG 529

Query: 573 KAKHLRLSLNEEGQCRVQHLWFQSIFDMLEHFRVHPIPLESGGS 616
           + KHL L ++ EG  R +   F+S+  ++ +   + +P+ S GS
Sbjct: 530 QPKHL-LLVDPEGVVRTKDHRFESVSHLISYHMDNHLPIISAGS 572


>gi|194239662 SHC (Src homology 2 domain containing) transforming
           protein 1 isoform 1 [Homo sapiens]
          Length = 583

 Score = 62.8 bits (151), Expect = 1e-09
 Identities = 39/104 (37%), Positives = 57/104 (54%), Gaps = 6/104 (5%)

Query: 513 PEGGEGDQPLSGYPWFHGMLSRLKAAQLVLTGGTGSHGVFLVRQSETRRGEYVLTFNFQG 572
           P+     + L G PWFHG LSR +A  L+   G      FLVR+S T  G+YVLT    G
Sbjct: 474 PQSVSMAEQLRGEPWFHGKLSRREAEALLQLNGD-----FLVRESTTTPGQYVLTGLQSG 528

Query: 573 KAKHLRLSLNEEGQCRVQHLWFQSIFDMLEHFRVHPIPLESGGS 616
           + KHL L ++ EG  R +   F+S+  ++ +   + +P+ S GS
Sbjct: 529 QPKHL-LLVDPEGVVRTKDHRFESVSHLISYHMDNHLPIISAGS 571


>gi|32261324 SHC (Src homology 2 domain containing) transforming
           protein 1 isoform 2 [Homo sapiens]
          Length = 474

 Score = 62.8 bits (151), Expect = 1e-09
 Identities = 39/104 (37%), Positives = 57/104 (54%), Gaps = 6/104 (5%)

Query: 513 PEGGEGDQPLSGYPWFHGMLSRLKAAQLVLTGGTGSHGVFLVRQSETRRGEYVLTFNFQG 572
           P+     + L G PWFHG LSR +A  L+   G      FLVR+S T  G+YVLT    G
Sbjct: 365 PQSVSMAEQLRGEPWFHGKLSRREAEALLQLNGD-----FLVRESTTTPGQYVLTGLQSG 419

Query: 573 KAKHLRLSLNEEGQCRVQHLWFQSIFDMLEHFRVHPIPLESGGS 616
           + KHL L ++ EG  R +   F+S+  ++ +   + +P+ S GS
Sbjct: 420 QPKHL-LLVDPEGVVRTKDHRFESVSHLISYHMDNHLPIISAGS 462


>gi|187475373 c-src tyrosine kinase [Homo sapiens]
          Length = 450

 Score = 57.4 bits (137), Expect = 4e-08
 Identities = 29/91 (31%), Positives = 51/91 (56%), Gaps = 3/91 (3%)

Query: 514 EGGEGDQPLSGYPWFHGMLSRLKAAQLVLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGK 573
           EG +    LS  PWFHG ++R +A +L+    TG   +FLVR+S    G+Y L  +  GK
Sbjct: 69  EGVKAGTKLSLMPWFHGKITREQAERLLYPPETG---LFLVRESTNYPGDYTLCVSCDGK 125

Query: 574 AKHLRLSLNEEGQCRVQHLWFQSIFDMLEHF 604
            +H R+  +       + ++F+++  ++EH+
Sbjct: 126 VEHYRIMYHASKLSIDEEVYFENLMQLVEHY 156


>gi|4758078 c-src tyrosine kinase [Homo sapiens]
          Length = 450

 Score = 57.4 bits (137), Expect = 4e-08
 Identities = 29/91 (31%), Positives = 51/91 (56%), Gaps = 3/91 (3%)

Query: 514 EGGEGDQPLSGYPWFHGMLSRLKAAQLVLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGK 573
           EG +    LS  PWFHG ++R +A +L+    TG   +FLVR+S    G+Y L  +  GK
Sbjct: 69  EGVKAGTKLSLMPWFHGKITREQAERLLYPPETG---LFLVRESTNYPGDYTLCVSCDGK 125

Query: 574 AKHLRLSLNEEGQCRVQHLWFQSIFDMLEHF 604
            +H R+  +       + ++F+++  ++EH+
Sbjct: 126 VEHYRIMYHASKLSIDEEVYFENLMQLVEHY 156


>gi|239751592 PREDICTED: hypothetical protein XP_002347924 [Homo
           sapiens]
          Length = 475

 Score = 57.0 bits (136), Expect = 6e-08
 Identities = 34/98 (34%), Positives = 54/98 (55%), Gaps = 6/98 (6%)

Query: 519 DQPLSGYPWFHGMLSRLKAAQLVLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLR 578
           ++ L   PW+HG +SR  A +++   G      FLVR S T  G+YVLT    G+ KHL 
Sbjct: 372 EEQLRQEPWYHGRMSRRAAERMLRADGD-----FLVRDSVTNPGQYVLTGMHAGQPKHL- 425

Query: 579 LSLNEEGQCRVQHLWFQSIFDMLEHFRVHPIPLESGGS 616
           L ++ EG  R + + F+SI  +++H   +  P+ +  S
Sbjct: 426 LLVDPEGVVRTKDVLFESISHLIDHHLQNGQPIVAAES 463


>gi|169790811 SHC (Src homology 2 domain containing) transforming
           protein 2 [Homo sapiens]
          Length = 582

 Score = 57.0 bits (136), Expect = 6e-08
 Identities = 34/98 (34%), Positives = 54/98 (55%), Gaps = 6/98 (6%)

Query: 519 DQPLSGYPWFHGMLSRLKAAQLVLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLR 578
           ++ L   PW+HG +SR  A +++   G      FLVR S T  G+YVLT    G+ KHL 
Sbjct: 479 EEQLRQEPWYHGRMSRRAAERMLRADGD-----FLVRDSVTNPGQYVLTGMHAGQPKHL- 532

Query: 579 LSLNEEGQCRVQHLWFQSIFDMLEHFRVHPIPLESGGS 616
           L ++ EG  R + + F+SI  +++H   +  P+ +  S
Sbjct: 533 LLVDPEGVVRTKDVLFESISHLIDHHLQNGQPIVAAES 570


>gi|224586793 src homology 2 domain-containing transforming protein
           C3 [Homo sapiens]
          Length = 594

 Score = 54.3 bits (129), Expect = 4e-07
 Identities = 35/97 (36%), Positives = 50/97 (51%), Gaps = 6/97 (6%)

Query: 520 QPLSGYPWFHGMLSRLKAAQLVLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRL 579
           + L    W+ G +SR +A  L+   G      FLVR+S T  G +VLT    G+AKHL L
Sbjct: 492 EELQAETWYQGEMSRKEAEGLLEKDGD-----FLVRKSTTNPGSFVLTGMHNGQAKHL-L 545

Query: 580 SLNEEGQCRVQHLWFQSIFDMLEHFRVHPIPLESGGS 616
            ++ EG  R +   F SI  ++ H     +P+ S GS
Sbjct: 546 LVDPEGTIRTKDRVFDSISHLINHHLESSLPIVSAGS 582


>gi|205277435 spleen tyrosine kinase isoform 2 [Homo sapiens]
          Length = 612

 Score = 54.3 bits (129), Expect = 4e-07
 Identities = 39/138 (28%), Positives = 66/138 (47%), Gaps = 18/138 (13%)

Query: 526 PWFHGMLSRLKAAQLVLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEG 585
           PWFHG +SR ++ Q+VL  G+ ++G FL+R +    G Y L    +GK  H R+  ++ G
Sbjct: 167 PWFHGKISREESEQIVLI-GSKTNGKFLIR-ARDNNGSYALCLLHEGKVLHYRIDKDKTG 224

Query: 586 QCRV-QHLWFQSIFDMLEHF--------RVHPIPLESGGSSDVV-------LVSYVPSSQ 629
           +  + +   F +++ ++EH+        RV  +P +  G+   V       L    P+S 
Sbjct: 225 KLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPASS 284

Query: 630 RQQGEQSRSAGEEVPVHP 647
             QG +  S     P  P
Sbjct: 285 PAQGNRQESTVSFNPYEP 302



 Score = 33.1 bits (74), Expect = 0.87
 Identities = 19/60 (31%), Positives = 31/60 (51%), Gaps = 1/60 (1%)

Query: 526 PWFHGMLSRLKAAQLVLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEG 585
           P+F G ++R +A   ++ GG  S G++L+RQS    G + L+     KA H  +     G
Sbjct: 14  PFFFGNITREEAEDYLVQGGM-SDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNG 72


>gi|21450844 megakaryocyte-associated tyrosine kinase isoform c
           [Homo sapiens]
          Length = 466

 Score = 53.1 bits (126), Expect = 8e-07
 Identities = 33/94 (35%), Positives = 51/94 (54%), Gaps = 5/94 (5%)

Query: 512 EPEGGEGDQPLSGYPWFHGMLSRLKAAQLVLTGGTGSHGVFLVRQSETRRGEYVLTFNFQ 571
           E E    D  LS  PWFHG +S  +A Q +        G+FLVR+S    G+YVL  +F 
Sbjct: 66  EREALSADPKLSLMPWFHGKISGQEAVQQLQPP---EDGLFLVRESARHPGDYVLCVSFG 122

Query: 572 GKAKHLRLSLNEEGQCRV-QHLWFQSIFDMLEHF 604
               H R+ L+ +G   + + ++F ++ DM+EH+
Sbjct: 123 RDVIHYRV-LHRDGHLTIDEAVFFCNLMDMVEHY 155


>gi|21450842 megakaryocyte-associated tyrosine kinase isoform b
           [Homo sapiens]
          Length = 508

 Score = 53.1 bits (126), Expect = 8e-07
 Identities = 33/94 (35%), Positives = 51/94 (54%), Gaps = 5/94 (5%)

Query: 512 EPEGGEGDQPLSGYPWFHGMLSRLKAAQLVLTGGTGSHGVFLVRQSETRRGEYVLTFNFQ 571
           E E    D  LS  PWFHG +S  +A Q +        G+FLVR+S    G+YVL  +F 
Sbjct: 108 EREALSADPKLSLMPWFHGKISGQEAVQQLQPP---EDGLFLVRESARHPGDYVLCVSFG 164

Query: 572 GKAKHLRLSLNEEGQCRV-QHLWFQSIFDMLEHF 604
               H R+ L+ +G   + + ++F ++ DM+EH+
Sbjct: 165 RDVIHYRV-LHRDGHLTIDEAVFFCNLMDMVEHY 197


>gi|21450846 megakaryocyte-associated tyrosine kinase isoform a
           [Homo sapiens]
          Length = 507

 Score = 53.1 bits (126), Expect = 8e-07
 Identities = 33/94 (35%), Positives = 51/94 (54%), Gaps = 5/94 (5%)

Query: 512 EPEGGEGDQPLSGYPWFHGMLSRLKAAQLVLTGGTGSHGVFLVRQSETRRGEYVLTFNFQ 571
           E E    D  LS  PWFHG +S  +A Q +        G+FLVR+S    G+YVL  +F 
Sbjct: 107 EREALSADPKLSLMPWFHGKISGQEAVQQLQPP---EDGLFLVRESARHPGDYVLCVSFG 163

Query: 572 GKAKHLRLSLNEEGQCRV-QHLWFQSIFDMLEHF 604
               H R+ L+ +G   + + ++F ++ DM+EH+
Sbjct: 164 RDVIHYRV-LHRDGHLTIDEAVFFCNLMDMVEHY 196


>gi|5453754 NCK adaptor protein 1 [Homo sapiens]
          Length = 377

 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 27/87 (31%), Positives = 49/87 (56%), Gaps = 3/87 (3%)

Query: 523 SGYPWFHGMLSRLKAAQLVLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLN 582
           +G PW++G ++R +A   +     G  G FL+R SE+   ++ ++   QGK KH ++ L 
Sbjct: 278 AGNPWYYGKVTRHQAEMAL--NERGHEGDFLIRDSESSPNDFSVSLKAQGKNKHFKVQLK 335

Query: 583 EEGQCRVQHLWFQSIFDMLEHFRVHPI 609
           E   C  Q   F ++ +++EH++  PI
Sbjct: 336 ETVYCIGQRK-FSTMEELVEHYKKAPI 361


>gi|222446609 rai-like protein [Homo sapiens]
          Length = 630

 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 41/135 (30%), Positives = 64/135 (47%), Gaps = 12/135 (8%)

Query: 486 TVHPLSAPYPPLDTPETATGSFLFQGEPEGGEGDQPLSGYPW----FHGMLSRLKAAQLV 541
           +  PL +P+     PET       Q  P        +    W    +HG LSR  A  L+
Sbjct: 483 SAQPLGSPWHCGKAPETVQPGATAQ--PASSHSLPHIKQQLWSEECYHGKLSRKAAESLL 540

Query: 542 LTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQCRVQHLWFQSIFDML 601
           +  G      FLVR+S T  G+YVL+    G+AKHL L ++ EG+ R +   F ++  ++
Sbjct: 541 VKDGD-----FLVRESATSPGQYVLSGLQGGQAKHL-LLVDPEGKVRTKDHVFDNVGHLI 594

Query: 602 EHFRVHPIPLESGGS 616
            +   + +P+ S GS
Sbjct: 595 RYHMDNSLPIISSGS 609


>gi|21361553 spleen tyrosine kinase isoform 1 [Homo sapiens]
          Length = 635

 Score = 51.2 bits (121), Expect = 3e-06
 Identities = 26/80 (32%), Positives = 48/80 (60%), Gaps = 3/80 (3%)

Query: 526 PWFHGMLSRLKAAQLVLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEG 585
           PWFHG +SR ++ Q+VL  G+ ++G FL+R +    G Y L    +GK  H R+  ++ G
Sbjct: 167 PWFHGKISREESEQIVLI-GSKTNGKFLIR-ARDNNGSYALCLLHEGKVLHYRIDKDKTG 224

Query: 586 QCRV-QHLWFQSIFDMLEHF 604
           +  + +   F +++ ++EH+
Sbjct: 225 KLSIPEGKKFDTLWQLVEHY 244



 Score = 33.1 bits (74), Expect = 0.87
 Identities = 19/60 (31%), Positives = 31/60 (51%), Gaps = 1/60 (1%)

Query: 526 PWFHGMLSRLKAAQLVLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEG 585
           P+F G ++R +A   ++ GG  S G++L+RQS    G + L+     KA H  +     G
Sbjct: 14  PFFFGNITREEAEDYLVQGGM-SDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNG 72


>gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo
           sapiens]
          Length = 1124

 Score = 51.2 bits (121), Expect = 3e-06
 Identities = 60/229 (26%), Positives = 88/229 (38%), Gaps = 24/229 (10%)

Query: 310 VPPKASRPRLSIPCS--SITDVRTTTALEMPDRENTFVVKVEGPSEYIMETVDAQHVKAW 367
           VP   + P L  P S  +++ ++ TT+L  P  + T       P +            + 
Sbjct: 391 VPHSLTSPSLQAPPSPLALSSLQATTSLGSPTLQATHSFLTMSPRQTQASLTSPSRPAST 450

Query: 368 VSDIQECLSPGPCPATSPRPMTLP--LAPGTSFLTRENTDSLELSCLNHSESLPSQDLLL 425
             D     +P   PA+ P   +L   ++P +S LT     +L  S  +HS   P   L++
Sbjct: 451 PPDSPPLQAPLSLPASPPLQTSLSPAVSPLSSPLTIHPLQALS-SLASHSPQAPLSSLIM 509

Query: 426 GPSESNDRLSQGAYGGLSDRPSASISPSSASIAASHFDSM-ELLPPEL-----PPRIPIE 479
            P E+   L+          PS    P  AS+     +++  L PP L     P   P  
Sbjct: 510 PPLETQSSLAP---------PSLQTPP--ASLTTPPLENLPSLAPPPLQTASAPLTTPHL 558

Query: 480 EGPPTGTVHPLSAPYPPLDTPETATGSFLFQGEPEG--GEGDQPLSGYP 526
           E PP     PL AP  PL TP   T S +    P+        PL G P
Sbjct: 559 ETPPCPAPCPLQAPPSPLTTPPPETPSSIATPPPQAPPALASPPLQGLP 607



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 107/452 (23%), Positives = 152/452 (33%), Gaps = 89/452 (19%)

Query: 81  ARASGSLSPPILAPLSPGAEISPHDLSLESCRVGGPLAVLGPSRSSEDLAGPLPSSVSSS 140
           AR   + +P +L P  PG+   P  ++  + RV G    +G    +E   G     +  +
Sbjct: 14  ARTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGG-----IGGA 68

Query: 141 STTSSKPKLKKRFSLRSVGRSVRG-SVRGILQWRGTVDPPSSAGPLETSSGPPVLGGN-S 198
           +   S P+       RS G S R  + R     RG   PP+      TS GP    G  S
Sbjct: 69  TIPESAPRAG---PTRSAGTSSRNPASRPPASGRGERAPPAK----NTSPGPVSSPGRAS 121

Query: 199 NSNSSGGAGTVGRGLVSDGTSPGERWTHRFERLRLSRGGGALKDGAG---------MVQR 249
            +   G  G  G  + ++ T    + T   +R  LS   GA +D +G         M +R
Sbjct: 122 GTTRPGPLGQKGLRISAEETVARGKATEAPKRSALS--AGARRDTSGPTPGTPSPAMARR 179

Query: 250 EELLSFMGAEEAAPDPAGVGRGGGVAGPPSGG-------GGQPQWQKCRLLLRSEGEGGG 302
                  G E   P PA   R      PP+ G         +    +     R     GG
Sbjct: 180 SRA---AGTEVGLPRPAPSAR----PRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGG 232

Query: 303 GSRLEFFVPPKASRPRLSIPCSSITDVR-TTTALEMPDRENTFVVKVEGPSEYIMETVDA 361
           G +        +S   LS P  S    R T  A   P +          P    ++ +  
Sbjct: 233 GLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQ----------PKPKGLQALRP 282

Query: 362 QHVKAWVSDIQECLSPGPCPATSPRPMTLPLAPGTSFLTRENTDSLELSCLNHSESLPSQ 421
             V     D    L P      S  P+  P   GT        D       N +  LP+ 
Sbjct: 283 PQVTPPRKDAAPALGP-----LSSSPLATPSPSGTKARPVPPPD-------NAATPLPA- 329

Query: 422 DLLLGPSESNDRLSQGAYGGLSDRPSASISPSSASIAASHFDSMELLPPELPPRIPIEEG 481
              L PS              +  P A  SPS+         S++ LP   PP  P  + 
Sbjct: 330 --TLPPSPPL----------ATPLPLAPPSPSAP-------PSLQTLPS--PPATPPSQA 368

Query: 482 PPTGTVHPLSAP-----YPPLDTPETATGSFL 508
           PP+ T  P+ AP      PP+  P + T   L
Sbjct: 369 PPSMTTPPMQAPPSLQTIPPIQVPHSLTSPSL 400



 Score = 37.0 bits (84), Expect = 0.060
 Identities = 79/297 (26%), Positives = 103/297 (34%), Gaps = 56/297 (18%)

Query: 4    APSPEDGASPSSPPLPPPP--PPSWR----EFCESHARAAALDFARRFRLYLASHPQYAG 57
            AP     + P SP   PPP  PP       +   S   +  L   RR        P   G
Sbjct: 811  APFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRR--------PPTPG 862

Query: 58   PGAEAAFSRRFAELFLQHFEAEVARASGSLSPPILAPLSPGAEISPHDL-SLESCRVGGP 116
            P    +  R    L            S +LS P LA  S  A  +P +L   +S   GG 
Sbjct: 863  PDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGA 922

Query: 117  LAVLGPSRSSEDLAGPLPSSVSSSSTTSSKPKLKKRFSLRSVGRSVRGSVRGILQWRGTV 176
             A   P     +LA   P++ S        P L           + RG+    L W    
Sbjct: 923  AASPPPDA---ELAACHPAAWSRGPA----PPL-----------AFRGAPGAPLPWPPAT 964

Query: 177  DPPSS---------AGPLETSSGPPVLGGNSNSNSSGGAGTVGRGLVSDGTSPGERWTHR 227
             P S+          GP   +  P  L    +  +SGG    G G  +   SP +    R
Sbjct: 965  GPGSADGLCTIYETEGPESATPAPGALDPGPSPGTSGGKAAAGAGAGASSRSPKQA---R 1021

Query: 228  FERLRLSRGGGALKDGAGMVQREELLS---FMGAEEAAPDPAGVGRGGGVAGPPSGG 281
               L L    GAL+  A +VQ   LLS    + A E A   +G G GG   G  +GG
Sbjct: 1022 LGELPL----GALQ--ASVVQ--HLLSRTLLLAAAEGAAGGSGGGPGGAEGGGVTGG 1070



 Score = 30.8 bits (68), Expect = 4.3
 Identities = 56/210 (26%), Positives = 77/210 (36%), Gaps = 29/210 (13%)

Query: 2   NGAPSPEDGASPSSPPLPPPPPPSWREFCESHARAAALDFARRFRLYLASHPQYAGPGAE 61
           +  P P+     ++PPL  PP P       S   + +     R    LA+ P    P   
Sbjct: 719 SATPPPQAPPPLAAPPLQVPPSPP-----ASPPMSPSATPPPRVPPLLAAPPLQVPPSPP 773

Query: 62  AAFSRRFAELFLQHFEAEVARASGSL----SPPIL----APLSPGAEISPHDLSLESCRV 113
           A+     + L     +A  A A+  L    SPP      AP SP A +            
Sbjct: 774 ASLP--MSPLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPM---------- 821

Query: 114 GGPLAVLGPSRSSEDLAGPLPSSVSSSSTTSSKPKLKKRFSLRSVGRSVRGSVRGILQWR 173
             PLA   P ++   LA PL   V  S   S   +  +R        SV G  R  L   
Sbjct: 822 -SPLAT-PPPQAPPVLAAPL-LQVPPSPPASPTLQAPRRPPTPGPDTSVSGP-RLTLALA 877

Query: 174 GTVDPPSSAGPLETSSGPPVLGGNSNSNSS 203
               PP S  P  T SGP + G +S++ S+
Sbjct: 878 PGPPPPPSRSPSSTLSGPDLAGHSSSATST 907


>gi|4506431 RAS p21 protein activator 1 isoform 1 [Homo sapiens]
          Length = 1047

 Score = 51.2 bits (121), Expect = 3e-06
 Identities = 29/96 (30%), Positives = 47/96 (48%), Gaps = 2/96 (2%)

Query: 514 EGGEGDQPLSGYPWFHGMLSRLKAAQLVLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGK 573
           E G  + P  G  WFHG +S+ +A  L++T   G    FLVR S+   G+Y L F     
Sbjct: 338 EVGREEDPHEGKIWFHGKISKQEAYNLLMT--VGQVCSFLVRPSDNTPGDYSLYFRTNEN 395

Query: 574 AKHLRLSLNEEGQCRVQHLWFQSIFDMLEHFRVHPI 609
            +  ++      Q  +   ++ SI D+++H+R   I
Sbjct: 396 IQRFKICPTPNNQFMMGGRYYNSIGDIIDHYRKEQI 431



 Score = 43.5 bits (101), Expect = 6e-04
 Identities = 50/181 (27%), Positives = 79/181 (43%), Gaps = 16/181 (8%)

Query: 437 GAYGGLS---DRPSASISPSSASIAASHF--DSMELLPPELPPRIPIEEGPPTGTVHPLS 491
           GA GG        +A ++ ++A +A +     S ++   +LP  +  E   P G   PL 
Sbjct: 79  GALGGAGLTGGGTAAGVAGAAAGVAGAAVAGPSGDMALTKLPTSLLAETLGPGGGFPPLP 138

Query: 492 AP--YPPLDTP--ETATGSFLFQGEPEGGEGDQPLSGYP---WFHGMLSRLKAAQLVLTG 544
            P   PPL         G  L   E E  E   PL+  P   W+HG L R  A + +   
Sbjct: 139 PPPYLPPLGAGLGTVDEGDSLDGPEYEEEEVAIPLTAPPTNQWYHGKLDRTIAEERLRQA 198

Query: 545 GTGSHGVFLVRQSETRRGEYVLTFNFQ-GKAKHLRLSLNEEGQCRVQHLWFQSIFDMLEH 603
           G    G +L+R+S+ R G +VL+F  Q     H R+ +   G   +    F S+ D++ +
Sbjct: 199 GKS--GSYLIRESDRRPGSFVLSFLSQMNVVNHFRI-IAMCGDYYIGGRRFSSLSDLIGY 255

Query: 604 F 604
           +
Sbjct: 256 Y 256


>gi|12545406 RAS p21 protein activator 1 isoform 2 [Homo sapiens]
          Length = 870

 Score = 51.2 bits (121), Expect = 3e-06
 Identities = 29/96 (30%), Positives = 47/96 (48%), Gaps = 2/96 (2%)

Query: 514 EGGEGDQPLSGYPWFHGMLSRLKAAQLVLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGK 573
           E G  + P  G  WFHG +S+ +A  L++T   G    FLVR S+   G+Y L F     
Sbjct: 161 EVGREEDPHEGKIWFHGKISKQEAYNLLMT--VGQVCSFLVRPSDNTPGDYSLYFRTNEN 218

Query: 574 AKHLRLSLNEEGQCRVQHLWFQSIFDMLEHFRVHPI 609
            +  ++      Q  +   ++ SI D+++H+R   I
Sbjct: 219 IQRFKICPTPNNQFMMGGRYYNSIGDIIDHYRKEQI 254



 Score = 35.4 bits (80), Expect = 0.18
 Identities = 23/79 (29%), Positives = 40/79 (50%), Gaps = 4/79 (5%)

Query: 527 WFHGMLSRLKAAQLVLTGGTGSHGVFLVRQSETRRGEYVLTFNFQ-GKAKHLRLSLNEEG 585
           W+HG L R  A + +   G    G +L+R+S+ R G +VL+F  Q     H R+ +   G
Sbjct: 4   WYHGKLDRTIAEERLRQAGKS--GSYLIRESDRRPGSFVLSFLSQMNVVNHFRI-IAMCG 60

Query: 586 QCRVQHLWFQSIFDMLEHF 604
              +    F S+ D++ ++
Sbjct: 61  DYYIGGRRFSSLSDLIGYY 79


>gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo
           sapiens]
          Length = 855

 Score = 50.8 bits (120), Expect = 4e-06
 Identities = 108/449 (24%), Positives = 159/449 (35%), Gaps = 45/449 (10%)

Query: 81  ARASGSLSPPILAPLSPGAEISPHDLSLESCRVGGPLAVLGPSRSSEDLAGPLPSSVSSS 140
           AR   + +P +L P  PG+   P  ++  + RV G    +G    +E   G     +  +
Sbjct: 14  ARTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGG-----IGGA 68

Query: 141 STTSSKPKLKKRFSLRSVGRSVRGSV-RGILQWRGTVDPPSSAGPLETSSGPPVLGGN-S 198
           +   S P+       RS G S R    R     RG   PP+      TS GP    G  S
Sbjct: 69  TIPESAPRAGPT---RSAGTSSRNPASRPPASGRGERAPPAK----NTSPGPVSSPGRAS 121

Query: 199 NSNSSGGAGTVGRGLVSDGTSPGERWTHRFERLRLSRGGGALKDGAGMVQREELLSFMGA 258
            +   G  G  G  + ++ T    + T   +R  LS   GA +D +G        +    
Sbjct: 122 GTTRPGPLGQKGLRISAEETVARGKATEAPKRSALS--AGARRDTSGPTPGTPSPAMARR 179

Query: 259 EEAAPDPAGVGRGGGVAGP--PSGG-------GGQPQWQKCRLLLRSEGEGGGGSRLEFF 309
             AA    G+ R    A P  P+ G         +    +     R     GGG +    
Sbjct: 180 SRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPAS 239

Query: 310 VPPKASRPRLSIPCSSITDVR-TTTALEMPDRENTFVVKVEGPSEYIMETVDAQHVKAWV 368
               +S   LS P  S    R T  A   P +     ++   P +      DA      +
Sbjct: 240 RSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPL 299

Query: 369 SDIQECLSPGPCPAT-SPRPMTLPLAPGTSFLTRENTDSLELSCLNHS-----ESLPSQD 422
           S      +P P  A  S  P TLP  P +S LT +    L L+  + S     ++LPS  
Sbjct: 300 SS-SPLATPSPSAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPP 358

Query: 423 LLLGPSESNDRLS----QGAYGGLSDRPSASIS-------PSSASIAASHFDSMELLPPE 471
               PS++   L     Q  +  L   P + ++       P+ A        S    PP 
Sbjct: 359 AT-PPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPL 417

Query: 472 LPPRIPIEEGPPTGTVHPLSAPYPPLDTP 500
            P   P  + P    VH L AP+ P  +P
Sbjct: 418 SPLATPSPQAPNALAVHLLQAPFSPPPSP 446



 Score = 37.7 bits (86), Expect = 0.035
 Identities = 87/339 (25%), Positives = 117/339 (34%), Gaps = 82/339 (24%)

Query: 4   APSPEDGASPSSPPLPPPPPPSWREFCESHARAAALDFAR---RFRLYLASHPQYAGPGA 60
           +P      SPS+ P P  PPP           A  L  A+   +    LA+ P  A P  
Sbjct: 484 SPPASPPMSPSATPPPQAPPP---------LAAPPLQLAKPPPQAPPALATPPLQALPSP 534

Query: 61  EAAFSRRFAELFLQHFEAEVARASGSLSPPILA-PLSPGAEISPHDLSLESCR------- 112
            A+F  +                    +PP+LA PL       P   +L++ R       
Sbjct: 535 PASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGP 594

Query: 113 ---VGGPLAVLG--------PSRS-SEDLAGPLPSSVSSSSTTSSKPKLKKRFSLRSVGR 160
              V GP   L         PSRS S  L+GP   +  SSS TS+  +L+   S    G 
Sbjct: 595 DTSVSGPRLTLALAPGPPPPPSRSPSSTLSGP-DLAGHSSSATSTPEELRGYDSGPEGGA 653

Query: 161 SV--------------------------RGSVRGILQWRGTVDPPSS---------AGPL 185
           +                           RG+    L W     P S+          GP 
Sbjct: 654 AASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPATGPGSADGLCTIYETEGPE 713

Query: 186 ETSSGPPVLGGNSNSNSSGGAGTVGRGLVSDGTSPGERWTHRFERLRLSRGGGALKDGAG 245
             +  P  L    +  +SGG    G G  +   SP +    R   L L    GAL+  A 
Sbjct: 714 SATPAPGALDPGPSPGTSGGKAAAGAGAGASSRSPKQA---RLGELPL----GALQ--AS 764

Query: 246 MVQREELLS---FMGAEEAAPDPAGVGRGGGVAGPPSGG 281
           +VQ   LLS    + A E A   +G G GG   G  +GG
Sbjct: 765 VVQ--HLLSRTLLLAAAEGAAGGSGGGPGGAEGGGVTGG 801



 Score = 30.8 bits (68), Expect = 4.3
 Identities = 51/194 (26%), Positives = 66/194 (34%), Gaps = 40/194 (20%)

Query: 13  PSSPPLPPPPPPSWREFCESHARAAALDFARRFRLYLASHPQYAGPGAEAAFSRRFAELF 72
           P SPP  PP  PS     ++    AA        L LA  P  A P          A   
Sbjct: 482 PPSPPASPPMSPSATPPPQAPPPLAAPP------LQLAKPPPQAPPA--------LATPP 527

Query: 73  LQHFEAEVARASGS--LSPPILAPLSPGAEISPHDLSLESCRVGGPLAVLGPSR-SSEDL 129
           LQ   +  A   G    SP    P+SP A   P    +    +  PL  + PS  +S  L
Sbjct: 528 LQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPV----LAAPLLQVPPSPPASPTL 583

Query: 130 AGPLPSSVSSSSTTSSKPKLKKRFSLRSVGRSVRGSVRGILQWRGTVDPPSSAGPLETSS 189
             P         T+ S P+L                    L       PP S  P  T S
Sbjct: 584 QAPRRPPTPGPDTSVSGPRLT-------------------LALAPGPPPPPSRSPSSTLS 624

Query: 190 GPPVLGGNSNSNSS 203
           GP + G +S++ S+
Sbjct: 625 GPDLAGHSSSATST 638


>gi|117320537 phospholipase C, gamma 2 [Homo sapiens]
          Length = 1265

 Score = 50.4 bits (119), Expect = 5e-06
 Identities = 31/92 (33%), Positives = 48/92 (52%), Gaps = 12/92 (13%)

Query: 524 GYPWFHGMLSRLKAAQLVL------TGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHL 577
           G  WFH  + +  +A+ +L      TGG    G FLVR+SET   +Y L+F   G+ +H 
Sbjct: 529 GEKWFHKKVEKRTSAEKLLQEYCMETGG--KDGTFLVRESETFPNDYTLSFWRSGRVQHC 586

Query: 578 RLSLNEEG----QCRVQHLWFQSIFDMLEHFR 605
           R+    EG         +L F SI+ +++H+R
Sbjct: 587 RIRSTMEGGTLKYYLTDNLTFSSIYALIQHYR 618



 Score = 43.1 bits (100), Expect = 8e-04
 Identities = 23/89 (25%), Positives = 45/89 (50%), Gaps = 3/89 (3%)

Query: 521 PLSGYPWFHGMLSRLKAAQLVLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLS 580
           P    PW++  LSR +A  +++       G FL+R+ E     Y +TF  +GK KH R++
Sbjct: 640 PHESKPWYYDSLSRGEAEDMLMR--IPRDGAFLIRKREGS-DSYAITFRARGKVKHCRIN 696

Query: 581 LNEEGQCRVQHLWFQSIFDMLEHFRVHPI 609
            +          +F+S+ +++ ++  H +
Sbjct: 697 RDGRHFVLGTSAYFESLVELVSYYEKHSL 725


>gi|41281821 SH2 domain containing 3C isoform a [Homo sapiens]
          Length = 860

 Score = 50.1 bits (118), Expect = 7e-06
 Identities = 54/242 (22%), Positives = 91/242 (37%), Gaps = 32/242 (13%)

Query: 438 AYGGLSDRPSASISPSSASIAASHFDSMELLPPELPPRIPIEEGPPTGTVHPLSAPYPPL 497
           A G L D P+   +PS+  +         +  PE+P     EE PP       +A  P  
Sbjct: 127 ATGPLEDTPAMEPNPSAVEVDP-------IRKPEVPTGDVEEERPPRDVHSERAAGEPEA 179

Query: 498 --DTPETATGSFLFQGEPEGGEGD---------QPLSGYPWFHGMLSRLKAAQLVLTGGT 546
             D  + +   ++    PE    +           L  + W+HG + R  +  LV   G 
Sbjct: 180 GSDYVKFSKEKYILDSSPEKLHKELEEELKLSSTDLRSHAWYHGRIPREVSETLVQRNGD 239

Query: 547 GSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLS----LNEEGQCRVQHLWFQSIFDMLE 602
                FL+R S T  G+YVLT  ++ +A H +++       E    +Q+L+ Q  FD + 
Sbjct: 240 -----FLIRDSLTSLGDYVLTCRWRNQALHFKINKVVVKAGESYTHIQYLFEQESFDHVP 294

Query: 603 HFRVHPIPLESGGSSDVVLVSYVPSSQR-----QQGEQSRSAGEEVPVHPRSEAGSRLGA 657
               + +      S     + Y P ++       +       G   P  P S +G +   
Sbjct: 295 ALVRYHVGSRKAVSEQSGAIIYCPVNRTFPLRYLEASYGLGQGSSKPASPVSPSGPKGSH 354

Query: 658 MR 659
           M+
Sbjct: 355 MK 356


>gi|33598948 phospholipase C, gamma 1 isoform a [Homo sapiens]
          Length = 1291

 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 32/101 (31%), Positives = 48/101 (47%), Gaps = 16/101 (15%)

Query: 523 SGYPWFHGMLS----------RLKAAQLVLTGGTGSHGVFLVRQSETRRGEYVLTFNFQG 572
           S   WFHG L           RL     + TG     G FLVR+SET  G+Y L+F   G
Sbjct: 546 SNEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPD--GSFLVRESETFVGDYTLSFWRNG 603

Query: 573 KAKHLRLSLNEEGQC----RVQHLWFQSIFDMLEHFRVHPI 609
           K +H R+   ++          +L F S++D++ H++  P+
Sbjct: 604 KVQHCRIHSRQDAGTPKFFLTDNLVFDSLYDLITHYQQVPL 644



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 25/84 (29%), Positives = 45/84 (53%), Gaps = 6/84 (7%)

Query: 527 WFHGMLSRLKAAQLVLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQ 586
           W+H  L+R +A  +++       G FLVR+       Y ++F  +GK KH R  + +EGQ
Sbjct: 668 WYHASLTRAQAEHMLMR--VPRDGAFLVRK-RNEPNSYAISFRAEGKIKHCR--VQQEGQ 722

Query: 587 -CRVQHLWFQSIFDMLEHFRVHPI 609
              + +  F S+ D++ ++  HP+
Sbjct: 723 TVMLGNSEFDSLVDLISYYEKHPL 746


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.313    0.132    0.400 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 35,247,550
Number of Sequences: 37866
Number of extensions: 2156087
Number of successful extensions: 19574
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 187
Number of HSP's successfully gapped in prelim test: 442
Number of HSP's that attempted gapping in prelim test: 15697
Number of HSP's gapped (non-prelim): 3865
length of query: 683
length of database: 18,247,518
effective HSP length: 109
effective length of query: 574
effective length of database: 14,120,124
effective search space: 8104951176
effective search space used: 8104951176
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 65 (29.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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