BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|224926822 SH2B adaptor protein 1 isoform 2 [Homo sapiens] (671 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|224926824 SH2B adaptor protein 1 isoform 2 [Homo sapiens] 1369 0.0 gi|224926828 SH2B adaptor protein 1 isoform 2 [Homo sapiens] 1369 0.0 gi|224926822 SH2B adaptor protein 1 isoform 2 [Homo sapiens] 1369 0.0 gi|224926830 SH2B adaptor protein 1 isoform 3 [Homo sapiens] 1290 0.0 gi|224926826 SH2B adaptor protein 1 isoform 1 [Homo sapiens] 1283 0.0 gi|242247193 SH2B adaptor protein 2 [Homo sapiens] 368 e-101 gi|4885455 SH2B adaptor protein 3 [Homo sapiens] 158 2e-38 gi|194239668 SHC (Src homology 2 domain containing) transforming... 63 1e-09 gi|194239664 SHC (Src homology 2 domain containing) transforming... 63 1e-09 gi|194239662 SHC (Src homology 2 domain containing) transforming... 63 1e-09 gi|32261324 SHC (Src homology 2 domain containing) transforming ... 63 1e-09 gi|187475373 c-src tyrosine kinase [Homo sapiens] 57 4e-08 gi|4758078 c-src tyrosine kinase [Homo sapiens] 57 4e-08 gi|239751592 PREDICTED: hypothetical protein XP_002347924 [Homo ... 57 6e-08 gi|169790811 SHC (Src homology 2 domain containing) transforming... 57 6e-08 gi|224586793 src homology 2 domain-containing transforming prote... 54 4e-07 gi|205277435 spleen tyrosine kinase isoform 2 [Homo sapiens] 53 8e-07 gi|21450844 megakaryocyte-associated tyrosine kinase isoform c [... 53 8e-07 gi|21450842 megakaryocyte-associated tyrosine kinase isoform b [... 53 8e-07 gi|21450846 megakaryocyte-associated tyrosine kinase isoform a [... 53 8e-07 gi|5453754 NCK adaptor protein 1 [Homo sapiens] 52 1e-06 gi|222446609 rai-like protein [Homo sapiens] 52 2e-06 gi|21361553 spleen tyrosine kinase isoform 1 [Homo sapiens] 51 3e-06 gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapi... 51 3e-06 gi|4506431 RAS p21 protein activator 1 isoform 1 [Homo sapiens] 51 3e-06 gi|12545406 RAS p21 protein activator 1 isoform 2 [Homo sapiens] 51 3e-06 gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo sapi... 51 4e-06 gi|117320537 phospholipase C, gamma 2 [Homo sapiens] 50 5e-06 gi|33598948 phospholipase C, gamma 1 isoform a [Homo sapiens] 49 2e-05 gi|33598946 phospholipase C, gamma 1 isoform b [Homo sapiens] 49 2e-05 >gi|224926824 SH2B adaptor protein 1 isoform 2 [Homo sapiens] Length = 671 Score = 1369 bits (3544), Expect = 0.0 Identities = 671/671 (100%), Positives = 671/671 (100%) Query: 1 MNGAPSPEDGASPSSPPLPPPPPPSWREFCESHARAAALDFARRFRLYLASHPQYAGPGA 60 MNGAPSPEDGASPSSPPLPPPPPPSWREFCESHARAAALDFARRFRLYLASHPQYAGPGA Sbjct: 1 MNGAPSPEDGASPSSPPLPPPPPPSWREFCESHARAAALDFARRFRLYLASHPQYAGPGA 60 Query: 61 EAAFSRRFAELFLQHFEAEVARASGSLSPPILAPLSPGAEISPHDLSLESCRVGGPLAVL 120 EAAFSRRFAELFLQHFEAEVARASGSLSPPILAPLSPGAEISPHDLSLESCRVGGPLAVL Sbjct: 61 EAAFSRRFAELFLQHFEAEVARASGSLSPPILAPLSPGAEISPHDLSLESCRVGGPLAVL 120 Query: 121 GPSRSSEDLAGPLPSSVSSSSTTSSKPKLKKRFSLRSVGRSVRGSVRGILQWRGTVDPPS 180 GPSRSSEDLAGPLPSSVSSSSTTSSKPKLKKRFSLRSVGRSVRGSVRGILQWRGTVDPPS Sbjct: 121 GPSRSSEDLAGPLPSSVSSSSTTSSKPKLKKRFSLRSVGRSVRGSVRGILQWRGTVDPPS 180 Query: 181 SAGPLETSSGPPVLGGNSNSNSSGGAGTVGRGLVSDGTSPGERWTHRFERLRLSRGGGAL 240 SAGPLETSSGPPVLGGNSNSNSSGGAGTVGRGLVSDGTSPGERWTHRFERLRLSRGGGAL Sbjct: 181 SAGPLETSSGPPVLGGNSNSNSSGGAGTVGRGLVSDGTSPGERWTHRFERLRLSRGGGAL 240 Query: 241 KDGAGMVQREELLSFMGAEEAAPDPAGVGRGGGVAGPPSGGGGQPQWQKCRLLLRSEGEG 300 KDGAGMVQREELLSFMGAEEAAPDPAGVGRGGGVAGPPSGGGGQPQWQKCRLLLRSEGEG Sbjct: 241 KDGAGMVQREELLSFMGAEEAAPDPAGVGRGGGVAGPPSGGGGQPQWQKCRLLLRSEGEG 300 Query: 301 GGGSRLEFFVPPKASRPRLSIPCSSITDVRTTTALEMPDRENTFVVKVEGPSEYIMETVD 360 GGGSRLEFFVPPKASRPRLSIPCSSITDVRTTTALEMPDRENTFVVKVEGPSEYIMETVD Sbjct: 301 GGGSRLEFFVPPKASRPRLSIPCSSITDVRTTTALEMPDRENTFVVKVEGPSEYIMETVD 360 Query: 361 AQHVKAWVSDIQECLSPGPCPATSPRPMTLPLAPGTSFLTRENTDSLELSCLNHSESLPS 420 AQHVKAWVSDIQECLSPGPCPATSPRPMTLPLAPGTSFLTRENTDSLELSCLNHSESLPS Sbjct: 361 AQHVKAWVSDIQECLSPGPCPATSPRPMTLPLAPGTSFLTRENTDSLELSCLNHSESLPS 420 Query: 421 QDLLLGPSESNDRLSQGAYGGLSDRPSASISPSSASIAASHFDSMELLPPELPPRIPIEE 480 QDLLLGPSESNDRLSQGAYGGLSDRPSASISPSSASIAASHFDSMELLPPELPPRIPIEE Sbjct: 421 QDLLLGPSESNDRLSQGAYGGLSDRPSASISPSSASIAASHFDSMELLPPELPPRIPIEE 480 Query: 481 GPPTGTVHPLSAPYPPLDTPETATGSFLFQGEPEGGEGDQPLSGYPWFHGMLSRLKAAQL 540 GPPTGTVHPLSAPYPPLDTPETATGSFLFQGEPEGGEGDQPLSGYPWFHGMLSRLKAAQL Sbjct: 481 GPPTGTVHPLSAPYPPLDTPETATGSFLFQGEPEGGEGDQPLSGYPWFHGMLSRLKAAQL 540 Query: 541 VLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQCRVQHLWFQSIFDM 600 VLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQCRVQHLWFQSIFDM Sbjct: 541 VLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQCRVQHLWFQSIFDM 600 Query: 601 LEHFRVHPIPLESGGSSDVVLVSYVPSSQRQQGREQAGSHAGVCEGDGCHPDASCTLMPF 660 LEHFRVHPIPLESGGSSDVVLVSYVPSSQRQQGREQAGSHAGVCEGDGCHPDASCTLMPF Sbjct: 601 LEHFRVHPIPLESGGSSDVVLVSYVPSSQRQQGREQAGSHAGVCEGDGCHPDASCTLMPF 660 Query: 661 GASDCVTDHLP 671 GASDCVTDHLP Sbjct: 661 GASDCVTDHLP 671 >gi|224926828 SH2B adaptor protein 1 isoform 2 [Homo sapiens] Length = 671 Score = 1369 bits (3544), Expect = 0.0 Identities = 671/671 (100%), Positives = 671/671 (100%) Query: 1 MNGAPSPEDGASPSSPPLPPPPPPSWREFCESHARAAALDFARRFRLYLASHPQYAGPGA 60 MNGAPSPEDGASPSSPPLPPPPPPSWREFCESHARAAALDFARRFRLYLASHPQYAGPGA Sbjct: 1 MNGAPSPEDGASPSSPPLPPPPPPSWREFCESHARAAALDFARRFRLYLASHPQYAGPGA 60 Query: 61 EAAFSRRFAELFLQHFEAEVARASGSLSPPILAPLSPGAEISPHDLSLESCRVGGPLAVL 120 EAAFSRRFAELFLQHFEAEVARASGSLSPPILAPLSPGAEISPHDLSLESCRVGGPLAVL Sbjct: 61 EAAFSRRFAELFLQHFEAEVARASGSLSPPILAPLSPGAEISPHDLSLESCRVGGPLAVL 120 Query: 121 GPSRSSEDLAGPLPSSVSSSSTTSSKPKLKKRFSLRSVGRSVRGSVRGILQWRGTVDPPS 180 GPSRSSEDLAGPLPSSVSSSSTTSSKPKLKKRFSLRSVGRSVRGSVRGILQWRGTVDPPS Sbjct: 121 GPSRSSEDLAGPLPSSVSSSSTTSSKPKLKKRFSLRSVGRSVRGSVRGILQWRGTVDPPS 180 Query: 181 SAGPLETSSGPPVLGGNSNSNSSGGAGTVGRGLVSDGTSPGERWTHRFERLRLSRGGGAL 240 SAGPLETSSGPPVLGGNSNSNSSGGAGTVGRGLVSDGTSPGERWTHRFERLRLSRGGGAL Sbjct: 181 SAGPLETSSGPPVLGGNSNSNSSGGAGTVGRGLVSDGTSPGERWTHRFERLRLSRGGGAL 240 Query: 241 KDGAGMVQREELLSFMGAEEAAPDPAGVGRGGGVAGPPSGGGGQPQWQKCRLLLRSEGEG 300 KDGAGMVQREELLSFMGAEEAAPDPAGVGRGGGVAGPPSGGGGQPQWQKCRLLLRSEGEG Sbjct: 241 KDGAGMVQREELLSFMGAEEAAPDPAGVGRGGGVAGPPSGGGGQPQWQKCRLLLRSEGEG 300 Query: 301 GGGSRLEFFVPPKASRPRLSIPCSSITDVRTTTALEMPDRENTFVVKVEGPSEYIMETVD 360 GGGSRLEFFVPPKASRPRLSIPCSSITDVRTTTALEMPDRENTFVVKVEGPSEYIMETVD Sbjct: 301 GGGSRLEFFVPPKASRPRLSIPCSSITDVRTTTALEMPDRENTFVVKVEGPSEYIMETVD 360 Query: 361 AQHVKAWVSDIQECLSPGPCPATSPRPMTLPLAPGTSFLTRENTDSLELSCLNHSESLPS 420 AQHVKAWVSDIQECLSPGPCPATSPRPMTLPLAPGTSFLTRENTDSLELSCLNHSESLPS Sbjct: 361 AQHVKAWVSDIQECLSPGPCPATSPRPMTLPLAPGTSFLTRENTDSLELSCLNHSESLPS 420 Query: 421 QDLLLGPSESNDRLSQGAYGGLSDRPSASISPSSASIAASHFDSMELLPPELPPRIPIEE 480 QDLLLGPSESNDRLSQGAYGGLSDRPSASISPSSASIAASHFDSMELLPPELPPRIPIEE Sbjct: 421 QDLLLGPSESNDRLSQGAYGGLSDRPSASISPSSASIAASHFDSMELLPPELPPRIPIEE 480 Query: 481 GPPTGTVHPLSAPYPPLDTPETATGSFLFQGEPEGGEGDQPLSGYPWFHGMLSRLKAAQL 540 GPPTGTVHPLSAPYPPLDTPETATGSFLFQGEPEGGEGDQPLSGYPWFHGMLSRLKAAQL Sbjct: 481 GPPTGTVHPLSAPYPPLDTPETATGSFLFQGEPEGGEGDQPLSGYPWFHGMLSRLKAAQL 540 Query: 541 VLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQCRVQHLWFQSIFDM 600 VLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQCRVQHLWFQSIFDM Sbjct: 541 VLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQCRVQHLWFQSIFDM 600 Query: 601 LEHFRVHPIPLESGGSSDVVLVSYVPSSQRQQGREQAGSHAGVCEGDGCHPDASCTLMPF 660 LEHFRVHPIPLESGGSSDVVLVSYVPSSQRQQGREQAGSHAGVCEGDGCHPDASCTLMPF Sbjct: 601 LEHFRVHPIPLESGGSSDVVLVSYVPSSQRQQGREQAGSHAGVCEGDGCHPDASCTLMPF 660 Query: 661 GASDCVTDHLP 671 GASDCVTDHLP Sbjct: 661 GASDCVTDHLP 671 >gi|224926822 SH2B adaptor protein 1 isoform 2 [Homo sapiens] Length = 671 Score = 1369 bits (3544), Expect = 0.0 Identities = 671/671 (100%), Positives = 671/671 (100%) Query: 1 MNGAPSPEDGASPSSPPLPPPPPPSWREFCESHARAAALDFARRFRLYLASHPQYAGPGA 60 MNGAPSPEDGASPSSPPLPPPPPPSWREFCESHARAAALDFARRFRLYLASHPQYAGPGA Sbjct: 1 MNGAPSPEDGASPSSPPLPPPPPPSWREFCESHARAAALDFARRFRLYLASHPQYAGPGA 60 Query: 61 EAAFSRRFAELFLQHFEAEVARASGSLSPPILAPLSPGAEISPHDLSLESCRVGGPLAVL 120 EAAFSRRFAELFLQHFEAEVARASGSLSPPILAPLSPGAEISPHDLSLESCRVGGPLAVL Sbjct: 61 EAAFSRRFAELFLQHFEAEVARASGSLSPPILAPLSPGAEISPHDLSLESCRVGGPLAVL 120 Query: 121 GPSRSSEDLAGPLPSSVSSSSTTSSKPKLKKRFSLRSVGRSVRGSVRGILQWRGTVDPPS 180 GPSRSSEDLAGPLPSSVSSSSTTSSKPKLKKRFSLRSVGRSVRGSVRGILQWRGTVDPPS Sbjct: 121 GPSRSSEDLAGPLPSSVSSSSTTSSKPKLKKRFSLRSVGRSVRGSVRGILQWRGTVDPPS 180 Query: 181 SAGPLETSSGPPVLGGNSNSNSSGGAGTVGRGLVSDGTSPGERWTHRFERLRLSRGGGAL 240 SAGPLETSSGPPVLGGNSNSNSSGGAGTVGRGLVSDGTSPGERWTHRFERLRLSRGGGAL Sbjct: 181 SAGPLETSSGPPVLGGNSNSNSSGGAGTVGRGLVSDGTSPGERWTHRFERLRLSRGGGAL 240 Query: 241 KDGAGMVQREELLSFMGAEEAAPDPAGVGRGGGVAGPPSGGGGQPQWQKCRLLLRSEGEG 300 KDGAGMVQREELLSFMGAEEAAPDPAGVGRGGGVAGPPSGGGGQPQWQKCRLLLRSEGEG Sbjct: 241 KDGAGMVQREELLSFMGAEEAAPDPAGVGRGGGVAGPPSGGGGQPQWQKCRLLLRSEGEG 300 Query: 301 GGGSRLEFFVPPKASRPRLSIPCSSITDVRTTTALEMPDRENTFVVKVEGPSEYIMETVD 360 GGGSRLEFFVPPKASRPRLSIPCSSITDVRTTTALEMPDRENTFVVKVEGPSEYIMETVD Sbjct: 301 GGGSRLEFFVPPKASRPRLSIPCSSITDVRTTTALEMPDRENTFVVKVEGPSEYIMETVD 360 Query: 361 AQHVKAWVSDIQECLSPGPCPATSPRPMTLPLAPGTSFLTRENTDSLELSCLNHSESLPS 420 AQHVKAWVSDIQECLSPGPCPATSPRPMTLPLAPGTSFLTRENTDSLELSCLNHSESLPS Sbjct: 361 AQHVKAWVSDIQECLSPGPCPATSPRPMTLPLAPGTSFLTRENTDSLELSCLNHSESLPS 420 Query: 421 QDLLLGPSESNDRLSQGAYGGLSDRPSASISPSSASIAASHFDSMELLPPELPPRIPIEE 480 QDLLLGPSESNDRLSQGAYGGLSDRPSASISPSSASIAASHFDSMELLPPELPPRIPIEE Sbjct: 421 QDLLLGPSESNDRLSQGAYGGLSDRPSASISPSSASIAASHFDSMELLPPELPPRIPIEE 480 Query: 481 GPPTGTVHPLSAPYPPLDTPETATGSFLFQGEPEGGEGDQPLSGYPWFHGMLSRLKAAQL 540 GPPTGTVHPLSAPYPPLDTPETATGSFLFQGEPEGGEGDQPLSGYPWFHGMLSRLKAAQL Sbjct: 481 GPPTGTVHPLSAPYPPLDTPETATGSFLFQGEPEGGEGDQPLSGYPWFHGMLSRLKAAQL 540 Query: 541 VLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQCRVQHLWFQSIFDM 600 VLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQCRVQHLWFQSIFDM Sbjct: 541 VLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQCRVQHLWFQSIFDM 600 Query: 601 LEHFRVHPIPLESGGSSDVVLVSYVPSSQRQQGREQAGSHAGVCEGDGCHPDASCTLMPF 660 LEHFRVHPIPLESGGSSDVVLVSYVPSSQRQQGREQAGSHAGVCEGDGCHPDASCTLMPF Sbjct: 601 LEHFRVHPIPLESGGSSDVVLVSYVPSSQRQQGREQAGSHAGVCEGDGCHPDASCTLMPF 660 Query: 661 GASDCVTDHLP 671 GASDCVTDHLP Sbjct: 661 GASDCVTDHLP 671 >gi|224926830 SH2B adaptor protein 1 isoform 3 [Homo sapiens] Length = 683 Score = 1290 bits (3337), Expect = 0.0 Identities = 643/673 (95%), Positives = 645/673 (95%), Gaps = 16/673 (2%) Query: 1 MNGAPSPEDGASPSSPPLPPPPPPSWREFCESHARAAALDFARRFRLYLASHPQYAGPGA 60 MNGAPSPEDGASPSSPPLPPPPPPSWREFCESHARAAALDFARRFRLYLASHPQYAGPGA Sbjct: 1 MNGAPSPEDGASPSSPPLPPPPPPSWREFCESHARAAALDFARRFRLYLASHPQYAGPGA 60 Query: 61 EAAFSRRFAELFLQHFEAEVARASGSLSPPILAPLSPGAEISPHDLSLESCRVGGPLAVL 120 EAAFSRRFAELFLQHFEAEVARASGSLSPPILAPLSPGAEISPHDLSLESCRVGGPLAVL Sbjct: 61 EAAFSRRFAELFLQHFEAEVARASGSLSPPILAPLSPGAEISPHDLSLESCRVGGPLAVL 120 Query: 121 GPSRSSEDLAGPLPSSVSSSSTTSSKPKLKKRFSLRSVGRSVRGSVRGILQWRGTVDPPS 180 GPSRSSEDLAGPLPSSVSSSSTTSSKPKLKKRFSLRSVGRSVRGSVRGILQWRGTVDPPS Sbjct: 121 GPSRSSEDLAGPLPSSVSSSSTTSSKPKLKKRFSLRSVGRSVRGSVRGILQWRGTVDPPS 180 Query: 181 SAGPLETSSGPPVLGGNSNSNSSGGAGTVGRGLVSDGTSPGERWTHRFERLRLSRGGGAL 240 SAGPLETSSGPPVLGGNSNSNSSGGAGTVGRGLVSDGTSPGERWTHRFERLRLSRGGGAL Sbjct: 181 SAGPLETSSGPPVLGGNSNSNSSGGAGTVGRGLVSDGTSPGERWTHRFERLRLSRGGGAL 240 Query: 241 KDGAGMVQREELLSFMGAEEAAPDPAGVGRGGGVAGPPSGGGGQPQWQKCRLLLRSEGEG 300 KDGAGMVQREELLSFMGAEEAAPDPAGVGRGGGVAGPPSGGGGQPQWQKCRLLLRSEGEG Sbjct: 241 KDGAGMVQREELLSFMGAEEAAPDPAGVGRGGGVAGPPSGGGGQPQWQKCRLLLRSEGEG 300 Query: 301 GGGSRLEFFVPPKASRPRLSIPCSSITDVRTTTALEMPDRENTFVVKVEGPSEYIMETVD 360 GGGSRLEFFVPPKASRPRLSIPCSSITDVRTTTALEMPDRENTFVVKVEGPSEYIMETVD Sbjct: 301 GGGSRLEFFVPPKASRPRLSIPCSSITDVRTTTALEMPDRENTFVVKVEGPSEYIMETVD 360 Query: 361 AQHVKAWVSDIQECLSPGPCPATSPRPMTLPLAPGTSFLTRENTDSLELSCLNHSESLPS 420 AQHVKAWVSDIQECLSPGPCPATSPRPMTLPLAPGTSFLTRENTDSLELSCLNHSESLPS Sbjct: 361 AQHVKAWVSDIQECLSPGPCPATSPRPMTLPLAPGTSFLTRENTDSLELSCLNHSESLPS 420 Query: 421 QDLLLGPSESNDRLSQGAYGGLSDRPSASISPSSASIAASHFDSMELLPPELPPRIPIEE 480 QDLLLGPSESNDRLSQGAYGGLSDRPSASISPSSASIAASHFDSMELLPPELPPRIPIEE Sbjct: 421 QDLLLGPSESNDRLSQGAYGGLSDRPSASISPSSASIAASHFDSMELLPPELPPRIPIEE 480 Query: 481 GPPTGTVHPLSAPYPPLDTPETATGSFLFQGEPEGGEGDQPLSGYPWFHGMLSRLKAAQL 540 GPPTGTVHPLSAPYPPLDTPETATGSFLFQGEPEGGEGDQPLSGYPWFHGMLSRLKAAQL Sbjct: 481 GPPTGTVHPLSAPYPPLDTPETATGSFLFQGEPEGGEGDQPLSGYPWFHGMLSRLKAAQL 540 Query: 541 VLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQCRVQHLWFQSIFDM 600 VLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQCRVQHLWFQSIFDM Sbjct: 541 VLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQCRVQHLWFQSIFDM 600 Query: 601 LEHFRVHPIPLESGGSSDVVLVSYVPSSQRQQG--------------REQAGSHAGVCEG 646 LEHFRVHPIPLESGGSSDVVLVSYVPSSQRQQG R +AGS G Sbjct: 601 LEHFRVHPIPLESGGSSDVVLVSYVPSSQRQQGEQSRSAGEEVPVHPRSEAGSRLGAMR- 659 Query: 647 DGCHPDASCTLMP 659 GC + T MP Sbjct: 660 -GCAREMDATPMP 671 >gi|224926826 SH2B adaptor protein 1 isoform 1 [Homo sapiens] Length = 756 Score = 1283 bits (3319), Expect = 0.0 Identities = 635/640 (99%), Positives = 635/640 (99%), Gaps = 2/640 (0%) Query: 1 MNGAPSPEDGASPSSPPLPPPPPPSWREFCESHARAAALDFARRFRLYLASHPQYAGPGA 60 MNGAPSPEDGASPSSPPLPPPPPPSWREFCESHARAAALDFARRFRLYLASHPQYAGPGA Sbjct: 1 MNGAPSPEDGASPSSPPLPPPPPPSWREFCESHARAAALDFARRFRLYLASHPQYAGPGA 60 Query: 61 EAAFSRRFAELFLQHFEAEVARASGSLSPPILAPLSPGAEISPHDLSLESCRVGGPLAVL 120 EAAFSRRFAELFLQHFEAEVARASGSLSPPILAPLSPGAEISPHDLSLESCRVGGPLAVL Sbjct: 61 EAAFSRRFAELFLQHFEAEVARASGSLSPPILAPLSPGAEISPHDLSLESCRVGGPLAVL 120 Query: 121 GPSRSSEDLAGPLPSSVSSSSTTSSKPKLKKRFSLRSVGRSVRGSVRGILQWRGTVDPPS 180 GPSRSSEDLAGPLPSSVSSSSTTSSKPKLKKRFSLRSVGRSVRGSVRGILQWRGTVDPPS Sbjct: 121 GPSRSSEDLAGPLPSSVSSSSTTSSKPKLKKRFSLRSVGRSVRGSVRGILQWRGTVDPPS 180 Query: 181 SAGPLETSSGPPVLGGNSNSNSSGGAGTVGRGLVSDGTSPGERWTHRFERLRLSRGGGAL 240 SAGPLETSSGPPVLGGNSNSNSSGGAGTVGRGLVSDGTSPGERWTHRFERLRLSRGGGAL Sbjct: 181 SAGPLETSSGPPVLGGNSNSNSSGGAGTVGRGLVSDGTSPGERWTHRFERLRLSRGGGAL 240 Query: 241 KDGAGMVQREELLSFMGAEEAAPDPAGVGRGGGVAGPPSGGGGQPQWQKCRLLLRSEGEG 300 KDGAGMVQREELLSFMGAEEAAPDPAGVGRGGGVAGPPSGGGGQPQWQKCRLLLRSEGEG Sbjct: 241 KDGAGMVQREELLSFMGAEEAAPDPAGVGRGGGVAGPPSGGGGQPQWQKCRLLLRSEGEG 300 Query: 301 GGGSRLEFFVPPKASRPRLSIPCSSITDVRTTTALEMPDRENTFVVKVEGPSEYIMETVD 360 GGGSRLEFFVPPKASRPRLSIPCSSITDVRTTTALEMPDRENTFVVKVEGPSEYIMETVD Sbjct: 301 GGGSRLEFFVPPKASRPRLSIPCSSITDVRTTTALEMPDRENTFVVKVEGPSEYIMETVD 360 Query: 361 AQHVKAWVSDIQECLSPGPCPATSPRPMTLPLAPGTSFLTRENTDSLELSCLNHSESLPS 420 AQHVKAWVSDIQECLSPGPCPATSPRPMTLPLAPGTSFLTRENTDSLELSCLNHSESLPS Sbjct: 361 AQHVKAWVSDIQECLSPGPCPATSPRPMTLPLAPGTSFLTRENTDSLELSCLNHSESLPS 420 Query: 421 QDLLLGPSESNDRLSQGAYGGLSDRPSASISPSSASIAASHFDSMELLPPELPPRIPIEE 480 QDLLLGPSESNDRLSQGAYGGLSDRPSASISPSSASIAASHFDSMELLPPELPPRIPIEE Sbjct: 421 QDLLLGPSESNDRLSQGAYGGLSDRPSASISPSSASIAASHFDSMELLPPELPPRIPIEE 480 Query: 481 GPPTGTVHPLSAPYPPLDTPETATGSFLFQGEPEGGEGDQPLSGYPWFHGMLSRLKAAQL 540 GPPTGTVHPLSAPYPPLDTPETATGSFLFQGEPEGGEGDQPLSGYPWFHGMLSRLKAAQL Sbjct: 481 GPPTGTVHPLSAPYPPLDTPETATGSFLFQGEPEGGEGDQPLSGYPWFHGMLSRLKAAQL 540 Query: 541 VLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQCRVQHLWFQSIFDM 600 VLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQCRVQHLWFQSIFDM Sbjct: 541 VLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQCRVQHLWFQSIFDM 600 Query: 601 LEHFRVHPIPLESGGSSDVVLVSYVPSSQRQQGREQAGSH 640 LEHFRVHPIPLESGGSSDVVLVSYVPSSQRQQ E SH Sbjct: 601 LEHFRVHPIPLESGGSSDVVLVSYVPSSQRQQ--EPTTSH 638 >gi|242247193 SH2B adaptor protein 2 [Homo sapiens] Length = 675 Score = 368 bits (944), Expect = e-101 Identities = 255/626 (40%), Positives = 327/626 (52%), Gaps = 112/626 (17%) Query: 1 MNGAPSPEDGASPSSPPLPPPPPPSWREFCESHARAAALDFARRFRLYLASHPQYAGPGA 60 MNGA G + ++P P P P WR+FCE HA+AAA+DFA +F +L +P Y P A Sbjct: 44 MNGAGP---GPAAAAPVPVPVPVPDWRQFCELHAQAAAVDFAHKFCRFLRDNPAYDTPDA 100 Query: 61 EAAFSRRFAELFLQHFEAEVARASGSLSPPILAPLSPGAEISPHDLSLESCRVGG-PLAV 119 A+FSR FA FL F EV R + P + GA +S + E A Sbjct: 101 GASFSRHFAANFLDVFGEEVRRVL------VAGPTTRGAAVSAEAMEPELADTSALKAAP 154 Query: 120 LGPSRSSEDLAGPLPSSVSSSSTTSSKPKLKKRFSLRSVGRSVRGSVRGILQWRGTVDPP 179 G SRSSED+ S+ ++K +++K FSLR++ V VR + R + +P Sbjct: 155 YGHSRSSEDV----------STHAATKARVRKGFSLRNMSLCVVDGVRDMWHRRASPEPD 204 Query: 180 SSAGPLETSSGPPVLGGNSNSNSSGGAGTVGRGLVSDGTSPGERWTHRFERLRLSRGGGA 239 ++A P P ++WT R LRLSR A Sbjct: 205 AAAAPRTAE-------------------------------PRDKWTRR---LRLSRTLAA 230 Query: 240 LKDGAGMVQREELLSFMGAEEAAPDPAGVGRGGGVAGPPSGGGGQPQWQKCRLLLRSEGE 299 + +QRE L FM A++AA +G GG QWQKCRLLLR Sbjct: 231 KVELVD-IQREGALRFMVADDAA----------------AGSGGSAQWQKCRLLLR-RAV 272 Query: 300 GGGGSRLEFFVPPKASRPRLSIPCSSITDVRTTTALEMPDRENTFVVKVEGPSEYIMETV 359 RLEFFVPPKASRP++SIP S+I +VRTT LEMP+++NTFV+KVE +EYI+ET+ Sbjct: 273 AEERFRLEFFVPPKASRPKVSIPLSAIIEVRTTMPLEMPEKDNTFVLKVENGAEYILETI 332 Query: 360 DAQHVKAWVSDIQECLSPGPCPATSPRPMTLPLAPGTSFLTRENTDSLELSCLNHSESLP 419 D+ +WV+DIQ C+ PG S L G +R + S EL L + LP Sbjct: 333 DSLQKHSWVADIQGCVDPGD----SEEDTELSCTRGGCLASRVASCSCEL--LTDAVDLP 386 Query: 420 SQDLLLGPSESNDRLSQGAYGGLSDRPSASISPSSASIAASHFDSMELLPPELPPRIPIE 479 P E+ A G A + A H + + L +P+E Sbjct: 387 R------PPETT------AVG--------------AVVTAPHSRGRDAVRESLI-HVPLE 419 Query: 480 EGPPTGTVHPLSAPYPPLDTPETATGSFLFQGEPEGGEGDQPLSGYPWFHGMLSRLKAAQ 539 T L +P + TG + +PE E + LS YPWFHG LSR+KAAQ Sbjct: 420 TFLQT-----LESPGGS-GSDSNNTGEQGAETDPEA-EPELELSDYPWFHGTLSRVKAAQ 472 Query: 540 LVLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQCRVQHLWFQSIFD 599 LVL GG +HG+F++RQSETR GEYVLTFNFQGKAKHLRLSLN GQC VQHLWFQS+ D Sbjct: 473 LVLAGGPRNHGLFVIRQSETRPGEYVLTFNFQGKAKHLRLSLNGHGQCHVQHLWFQSVLD 532 Query: 600 MLEHFRVHPIPLESGGSSDVVLVSYV 625 ML HF HPIPLESGGS+D+ L SYV Sbjct: 533 MLRHFHTHPIPLESGGSADITLRSYV 558 >gi|4885455 SH2B adaptor protein 3 [Homo sapiens] Length = 575 Score = 158 bits (399), Expect = 2e-38 Identities = 87/146 (59%), Positives = 97/146 (66%), Gaps = 7/146 (4%) Query: 487 VHPLSAPYPPLDTPETATGSFLFQGEPEGG-------EGDQPLSGYPWFHGMLSRLKAAQ 539 +H SA P + + L QG GG + D LS YPWFHG +SR+KAAQ Sbjct: 317 MHIPSALEPSTSSSPRGSTDSLNQGASPGGLLDPACQKTDHFLSCYPWFHGPISRVKAAQ 376 Query: 540 LVLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQCRVQHLWFQSIFD 599 LV G +HGVFLVRQSETRRGEYVLTFNFQG AKHLRLSL E GQCRVQHL F S+ D Sbjct: 377 LVQLQGPDAHGVFLVRQSETRRGEYVLTFNFQGIAKHLRLSLTERGQCRVQHLHFPSVVD 436 Query: 600 MLEHFRVHPIPLESGGSSDVVLVSYV 625 ML HF+ PIPLE G + DV L SYV Sbjct: 437 MLHHFQRSPIPLECGAACDVRLSSYV 462 Score = 131 bits (330), Expect = 2e-30 Identities = 127/409 (31%), Positives = 177/409 (43%), Gaps = 91/409 (22%) Query: 11 ASPSSPPLPPPP--PPSWREFCESHARAAALDFARRFRLYLASHPQYAGPGAEAAFSRRF 68 +SPSS P P P W EFCE HA AAA + AR++ L+ HPQ+A AE S +F Sbjct: 9 SSPSSAPSASPAAAPRGWSEFCELHAVAAARELARQYWLFAREHPQHAPLRAELV-SLQF 67 Query: 69 AELFLQHFEAEV--ARASG------SLSPPILAPLSPGAEISPHDLSLESCRVGGPLAV- 119 +LF ++F EV RA G PP A SP E P GP A Sbjct: 68 TDLFQRYFCREVRDGRAPGRDYRDTGRGPPAKAEASP--EPGP-----------GPAAPG 114 Query: 120 LGPSRSSEDLAGPLPSSVSSSSTTSSKPKLKKRFSLRSVGRSVRGSVRGILQWRGTVDPP 179 L +RSSE+LA P P S + R S+R I + R + P Sbjct: 115 LPKARSSEELAPPRPPGPCSF-------------------QHFRRSLRHIFRRRSAGELP 155 Query: 180 SSAGPLETSSGPPVLGGNSNSNSSGGAGTVGRGLVSDGTSPGERWTHRFERLRLSRGGGA 239 ++ T++ P G + + + G +F L+R Sbjct: 156 AA----HTAAAPGTPGEAAETPARPGLAK------------------KFLPWSLAR---- 189 Query: 240 LKDGAGMVQREELLSFMGAEEAAPDPAGVGRGGGVAGPPSGGGGQPQWQKCRLLLR-SEG 298 + +E +L + A+EA+ D +WQ+ RL LR + G Sbjct: 190 --EPPPEALKEAVLRYSLADEASMDSGA------------------RWQRGRLALRRAPG 229 Query: 299 EGGGGSRLEFFVPPKASRPRLSIPCSSITDVRTTTALEMPDRENTFVVKVEGPSEYIMET 358 G LE F PPK+SRP+L CSSI +VR T LEMPD TFV+KV+ ++ I E Sbjct: 230 PDGPDRVLELFDPPKSSRPKLQAACSSIQEVRWCTRLEMPDNLYTFVLKVKDRTDIIFEV 289 Query: 359 VDAQHVKAWVSDIQECLSPGPCPATSPRPMTLPLAPGTSFLTRENTDSL 407 D Q + +W++++ EC G + + L P TS R +TDSL Sbjct: 290 GDEQQLNSWMAELSECTGRGLESTEAEMHIPSALEPSTSSSPRGSTDSL 338 >gi|194239668 SHC (Src homology 2 domain containing) transforming protein 1 isoform 4 [Homo sapiens] Length = 473 Score = 62.8 bits (151), Expect = 1e-09 Identities = 39/104 (37%), Positives = 57/104 (54%), Gaps = 6/104 (5%) Query: 513 PEGGEGDQPLSGYPWFHGMLSRLKAAQLVLTGGTGSHGVFLVRQSETRRGEYVLTFNFQG 572 P+ + L G PWFHG LSR +A L+ G FLVR+S T G+YVLT G Sbjct: 364 PQSVSMAEQLRGEPWFHGKLSRREAEALLQLNGD-----FLVRESTTTPGQYVLTGLQSG 418 Query: 573 KAKHLRLSLNEEGQCRVQHLWFQSIFDMLEHFRVHPIPLESGGS 616 + KHL L ++ EG R + F+S+ ++ + + +P+ S GS Sbjct: 419 QPKHL-LLVDPEGVVRTKDHRFESVSHLISYHMDNHLPIISAGS 461 >gi|194239664 SHC (Src homology 2 domain containing) transforming protein 1 isoform 3 [Homo sapiens] Length = 584 Score = 62.8 bits (151), Expect = 1e-09 Identities = 39/104 (37%), Positives = 57/104 (54%), Gaps = 6/104 (5%) Query: 513 PEGGEGDQPLSGYPWFHGMLSRLKAAQLVLTGGTGSHGVFLVRQSETRRGEYVLTFNFQG 572 P+ + L G PWFHG LSR +A L+ G FLVR+S T G+YVLT G Sbjct: 475 PQSVSMAEQLRGEPWFHGKLSRREAEALLQLNGD-----FLVRESTTTPGQYVLTGLQSG 529 Query: 573 KAKHLRLSLNEEGQCRVQHLWFQSIFDMLEHFRVHPIPLESGGS 616 + KHL L ++ EG R + F+S+ ++ + + +P+ S GS Sbjct: 530 QPKHL-LLVDPEGVVRTKDHRFESVSHLISYHMDNHLPIISAGS 572 >gi|194239662 SHC (Src homology 2 domain containing) transforming protein 1 isoform 1 [Homo sapiens] Length = 583 Score = 62.8 bits (151), Expect = 1e-09 Identities = 39/104 (37%), Positives = 57/104 (54%), Gaps = 6/104 (5%) Query: 513 PEGGEGDQPLSGYPWFHGMLSRLKAAQLVLTGGTGSHGVFLVRQSETRRGEYVLTFNFQG 572 P+ + L G PWFHG LSR +A L+ G FLVR+S T G+YVLT G Sbjct: 474 PQSVSMAEQLRGEPWFHGKLSRREAEALLQLNGD-----FLVRESTTTPGQYVLTGLQSG 528 Query: 573 KAKHLRLSLNEEGQCRVQHLWFQSIFDMLEHFRVHPIPLESGGS 616 + KHL L ++ EG R + F+S+ ++ + + +P+ S GS Sbjct: 529 QPKHL-LLVDPEGVVRTKDHRFESVSHLISYHMDNHLPIISAGS 571 >gi|32261324 SHC (Src homology 2 domain containing) transforming protein 1 isoform 2 [Homo sapiens] Length = 474 Score = 62.8 bits (151), Expect = 1e-09 Identities = 39/104 (37%), Positives = 57/104 (54%), Gaps = 6/104 (5%) Query: 513 PEGGEGDQPLSGYPWFHGMLSRLKAAQLVLTGGTGSHGVFLVRQSETRRGEYVLTFNFQG 572 P+ + L G PWFHG LSR +A L+ G FLVR+S T G+YVLT G Sbjct: 365 PQSVSMAEQLRGEPWFHGKLSRREAEALLQLNGD-----FLVRESTTTPGQYVLTGLQSG 419 Query: 573 KAKHLRLSLNEEGQCRVQHLWFQSIFDMLEHFRVHPIPLESGGS 616 + KHL L ++ EG R + F+S+ ++ + + +P+ S GS Sbjct: 420 QPKHL-LLVDPEGVVRTKDHRFESVSHLISYHMDNHLPIISAGS 462 >gi|187475373 c-src tyrosine kinase [Homo sapiens] Length = 450 Score = 57.4 bits (137), Expect = 4e-08 Identities = 29/91 (31%), Positives = 51/91 (56%), Gaps = 3/91 (3%) Query: 514 EGGEGDQPLSGYPWFHGMLSRLKAAQLVLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGK 573 EG + LS PWFHG ++R +A +L+ TG +FLVR+S G+Y L + GK Sbjct: 69 EGVKAGTKLSLMPWFHGKITREQAERLLYPPETG---LFLVRESTNYPGDYTLCVSCDGK 125 Query: 574 AKHLRLSLNEEGQCRVQHLWFQSIFDMLEHF 604 +H R+ + + ++F+++ ++EH+ Sbjct: 126 VEHYRIMYHASKLSIDEEVYFENLMQLVEHY 156 >gi|4758078 c-src tyrosine kinase [Homo sapiens] Length = 450 Score = 57.4 bits (137), Expect = 4e-08 Identities = 29/91 (31%), Positives = 51/91 (56%), Gaps = 3/91 (3%) Query: 514 EGGEGDQPLSGYPWFHGMLSRLKAAQLVLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGK 573 EG + LS PWFHG ++R +A +L+ TG +FLVR+S G+Y L + GK Sbjct: 69 EGVKAGTKLSLMPWFHGKITREQAERLLYPPETG---LFLVRESTNYPGDYTLCVSCDGK 125 Query: 574 AKHLRLSLNEEGQCRVQHLWFQSIFDMLEHF 604 +H R+ + + ++F+++ ++EH+ Sbjct: 126 VEHYRIMYHASKLSIDEEVYFENLMQLVEHY 156 >gi|239751592 PREDICTED: hypothetical protein XP_002347924 [Homo sapiens] Length = 475 Score = 57.0 bits (136), Expect = 6e-08 Identities = 34/98 (34%), Positives = 54/98 (55%), Gaps = 6/98 (6%) Query: 519 DQPLSGYPWFHGMLSRLKAAQLVLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLR 578 ++ L PW+HG +SR A +++ G FLVR S T G+YVLT G+ KHL Sbjct: 372 EEQLRQEPWYHGRMSRRAAERMLRADGD-----FLVRDSVTNPGQYVLTGMHAGQPKHL- 425 Query: 579 LSLNEEGQCRVQHLWFQSIFDMLEHFRVHPIPLESGGS 616 L ++ EG R + + F+SI +++H + P+ + S Sbjct: 426 LLVDPEGVVRTKDVLFESISHLIDHHLQNGQPIVAAES 463 >gi|169790811 SHC (Src homology 2 domain containing) transforming protein 2 [Homo sapiens] Length = 582 Score = 57.0 bits (136), Expect = 6e-08 Identities = 34/98 (34%), Positives = 54/98 (55%), Gaps = 6/98 (6%) Query: 519 DQPLSGYPWFHGMLSRLKAAQLVLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLR 578 ++ L PW+HG +SR A +++ G FLVR S T G+YVLT G+ KHL Sbjct: 479 EEQLRQEPWYHGRMSRRAAERMLRADGD-----FLVRDSVTNPGQYVLTGMHAGQPKHL- 532 Query: 579 LSLNEEGQCRVQHLWFQSIFDMLEHFRVHPIPLESGGS 616 L ++ EG R + + F+SI +++H + P+ + S Sbjct: 533 LLVDPEGVVRTKDVLFESISHLIDHHLQNGQPIVAAES 570 >gi|224586793 src homology 2 domain-containing transforming protein C3 [Homo sapiens] Length = 594 Score = 54.3 bits (129), Expect = 4e-07 Identities = 35/97 (36%), Positives = 50/97 (51%), Gaps = 6/97 (6%) Query: 520 QPLSGYPWFHGMLSRLKAAQLVLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRL 579 + L W+ G +SR +A L+ G FLVR+S T G +VLT G+AKHL L Sbjct: 492 EELQAETWYQGEMSRKEAEGLLEKDGD-----FLVRKSTTNPGSFVLTGMHNGQAKHL-L 545 Query: 580 SLNEEGQCRVQHLWFQSIFDMLEHFRVHPIPLESGGS 616 ++ EG R + F SI ++ H +P+ S GS Sbjct: 546 LVDPEGTIRTKDRVFDSISHLINHHLESSLPIVSAGS 582 >gi|205277435 spleen tyrosine kinase isoform 2 [Homo sapiens] Length = 612 Score = 53.1 bits (126), Expect = 8e-07 Identities = 39/145 (26%), Positives = 69/145 (47%), Gaps = 21/145 (14%) Query: 526 PWFHGMLSRLKAAQLVLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEG 585 PWFHG +SR ++ Q+VL G+ ++G FL+R + G Y L +GK H R+ ++ G Sbjct: 167 PWFHGKISREESEQIVLI-GSKTNGKFLIR-ARDNNGSYALCLLHEGKVLHYRIDKDKTG 224 Query: 586 QCRV-QHLWFQSIFDMLEHF--------RVHPIPLESGGSSDVVLVSYVPSSQRQQGREQ 636 + + + F +++ ++EH+ RV +P + G+ V GR Q Sbjct: 225 KLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKIGTQGNVNFG---------GRPQ 275 Query: 637 -AGSHAGVCEGDGCHPDASCTLMPF 660 GSH G +++ + P+ Sbjct: 276 LPGSHPASSPAQGNRQESTVSFNPY 300 Score = 33.1 bits (74), Expect = 0.85 Identities = 19/60 (31%), Positives = 31/60 (51%), Gaps = 1/60 (1%) Query: 526 PWFHGMLSRLKAAQLVLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEG 585 P+F G ++R +A ++ GG S G++L+RQS G + L+ KA H + G Sbjct: 14 PFFFGNITREEAEDYLVQGGM-SDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNG 72 >gi|21450844 megakaryocyte-associated tyrosine kinase isoform c [Homo sapiens] Length = 466 Score = 53.1 bits (126), Expect = 8e-07 Identities = 33/94 (35%), Positives = 51/94 (54%), Gaps = 5/94 (5%) Query: 512 EPEGGEGDQPLSGYPWFHGMLSRLKAAQLVLTGGTGSHGVFLVRQSETRRGEYVLTFNFQ 571 E E D LS PWFHG +S +A Q + G+FLVR+S G+YVL +F Sbjct: 66 EREALSADPKLSLMPWFHGKISGQEAVQQLQPP---EDGLFLVRESARHPGDYVLCVSFG 122 Query: 572 GKAKHLRLSLNEEGQCRV-QHLWFQSIFDMLEHF 604 H R+ L+ +G + + ++F ++ DM+EH+ Sbjct: 123 RDVIHYRV-LHRDGHLTIDEAVFFCNLMDMVEHY 155 >gi|21450842 megakaryocyte-associated tyrosine kinase isoform b [Homo sapiens] Length = 508 Score = 53.1 bits (126), Expect = 8e-07 Identities = 33/94 (35%), Positives = 51/94 (54%), Gaps = 5/94 (5%) Query: 512 EPEGGEGDQPLSGYPWFHGMLSRLKAAQLVLTGGTGSHGVFLVRQSETRRGEYVLTFNFQ 571 E E D LS PWFHG +S +A Q + G+FLVR+S G+YVL +F Sbjct: 108 EREALSADPKLSLMPWFHGKISGQEAVQQLQPP---EDGLFLVRESARHPGDYVLCVSFG 164 Query: 572 GKAKHLRLSLNEEGQCRV-QHLWFQSIFDMLEHF 604 H R+ L+ +G + + ++F ++ DM+EH+ Sbjct: 165 RDVIHYRV-LHRDGHLTIDEAVFFCNLMDMVEHY 197 >gi|21450846 megakaryocyte-associated tyrosine kinase isoform a [Homo sapiens] Length = 507 Score = 53.1 bits (126), Expect = 8e-07 Identities = 33/94 (35%), Positives = 51/94 (54%), Gaps = 5/94 (5%) Query: 512 EPEGGEGDQPLSGYPWFHGMLSRLKAAQLVLTGGTGSHGVFLVRQSETRRGEYVLTFNFQ 571 E E D LS PWFHG +S +A Q + G+FLVR+S G+YVL +F Sbjct: 107 EREALSADPKLSLMPWFHGKISGQEAVQQLQPP---EDGLFLVRESARHPGDYVLCVSFG 163 Query: 572 GKAKHLRLSLNEEGQCRV-QHLWFQSIFDMLEHF 604 H R+ L+ +G + + ++F ++ DM+EH+ Sbjct: 164 RDVIHYRV-LHRDGHLTIDEAVFFCNLMDMVEHY 196 >gi|5453754 NCK adaptor protein 1 [Homo sapiens] Length = 377 Score = 52.4 bits (124), Expect = 1e-06 Identities = 27/87 (31%), Positives = 49/87 (56%), Gaps = 3/87 (3%) Query: 523 SGYPWFHGMLSRLKAAQLVLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLN 582 +G PW++G ++R +A + G G FL+R SE+ ++ ++ QGK KH ++ L Sbjct: 278 AGNPWYYGKVTRHQAEMAL--NERGHEGDFLIRDSESSPNDFSVSLKAQGKNKHFKVQLK 335 Query: 583 EEGQCRVQHLWFQSIFDMLEHFRVHPI 609 E C Q F ++ +++EH++ PI Sbjct: 336 ETVYCIGQRK-FSTMEELVEHYKKAPI 361 >gi|222446609 rai-like protein [Homo sapiens] Length = 630 Score = 52.0 bits (123), Expect = 2e-06 Identities = 41/135 (30%), Positives = 64/135 (47%), Gaps = 12/135 (8%) Query: 486 TVHPLSAPYPPLDTPETATGSFLFQGEPEGGEGDQPLSGYPW----FHGMLSRLKAAQLV 541 + PL +P+ PET Q P + W +HG LSR A L+ Sbjct: 483 SAQPLGSPWHCGKAPETVQPGATAQ--PASSHSLPHIKQQLWSEECYHGKLSRKAAESLL 540 Query: 542 LTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQCRVQHLWFQSIFDML 601 + G FLVR+S T G+YVL+ G+AKHL L ++ EG+ R + F ++ ++ Sbjct: 541 VKDGD-----FLVRESATSPGQYVLSGLQGGQAKHL-LLVDPEGKVRTKDHVFDNVGHLI 594 Query: 602 EHFRVHPIPLESGGS 616 + + +P+ S GS Sbjct: 595 RYHMDNSLPIISSGS 609 >gi|21361553 spleen tyrosine kinase isoform 1 [Homo sapiens] Length = 635 Score = 51.2 bits (121), Expect = 3e-06 Identities = 26/80 (32%), Positives = 48/80 (60%), Gaps = 3/80 (3%) Query: 526 PWFHGMLSRLKAAQLVLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEG 585 PWFHG +SR ++ Q+VL G+ ++G FL+R + G Y L +GK H R+ ++ G Sbjct: 167 PWFHGKISREESEQIVLI-GSKTNGKFLIR-ARDNNGSYALCLLHEGKVLHYRIDKDKTG 224 Query: 586 QCRV-QHLWFQSIFDMLEHF 604 + + + F +++ ++EH+ Sbjct: 225 KLSIPEGKKFDTLWQLVEHY 244 Score = 33.1 bits (74), Expect = 0.85 Identities = 19/60 (31%), Positives = 31/60 (51%), Gaps = 1/60 (1%) Query: 526 PWFHGMLSRLKAAQLVLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEG 585 P+F G ++R +A ++ GG S G++L+RQS G + L+ KA H + G Sbjct: 14 PFFFGNITREEAEDYLVQGGM-SDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNG 72 >gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapiens] Length = 1124 Score = 51.2 bits (121), Expect = 3e-06 Identities = 60/229 (26%), Positives = 88/229 (38%), Gaps = 24/229 (10%) Query: 310 VPPKASRPRLSIPCS--SITDVRTTTALEMPDRENTFVVKVEGPSEYIMETVDAQHVKAW 367 VP + P L P S +++ ++ TT+L P + T P + + Sbjct: 391 VPHSLTSPSLQAPPSPLALSSLQATTSLGSPTLQATHSFLTMSPRQTQASLTSPSRPAST 450 Query: 368 VSDIQECLSPGPCPATSPRPMTLP--LAPGTSFLTRENTDSLELSCLNHSESLPSQDLLL 425 D +P PA+ P +L ++P +S LT +L S +HS P L++ Sbjct: 451 PPDSPPLQAPLSLPASPPLQTSLSPAVSPLSSPLTIHPLQALS-SLASHSPQAPLSSLIM 509 Query: 426 GPSESNDRLSQGAYGGLSDRPSASISPSSASIAASHFDSM-ELLPPEL-----PPRIPIE 479 P E+ L+ PS P AS+ +++ L PP L P P Sbjct: 510 PPLETQSSLAP---------PSLQTPP--ASLTTPPLENLPSLAPPPLQTASAPLTTPHL 558 Query: 480 EGPPTGTVHPLSAPYPPLDTPETATGSFLFQGEPEG--GEGDQPLSGYP 526 E PP PL AP PL TP T S + P+ PL G P Sbjct: 559 ETPPCPAPCPLQAPPSPLTTPPPETPSSIATPPPQAPPALASPPLQGLP 607 Score = 41.2 bits (95), Expect = 0.003 Identities = 107/452 (23%), Positives = 152/452 (33%), Gaps = 89/452 (19%) Query: 81 ARASGSLSPPILAPLSPGAEISPHDLSLESCRVGGPLAVLGPSRSSEDLAGPLPSSVSSS 140 AR + +P +L P PG+ P ++ + RV G +G +E G + + Sbjct: 14 ARTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGG-----IGGA 68 Query: 141 STTSSKPKLKKRFSLRSVGRSVRG-SVRGILQWRGTVDPPSSAGPLETSSGPPVLGGN-S 198 + S P+ RS G S R + R RG PP+ TS GP G S Sbjct: 69 TIPESAPRAG---PTRSAGTSSRNPASRPPASGRGERAPPAK----NTSPGPVSSPGRAS 121 Query: 199 NSNSSGGAGTVGRGLVSDGTSPGERWTHRFERLRLSRGGGALKDGAG---------MVQR 249 + G G G + ++ T + T +R LS GA +D +G M +R Sbjct: 122 GTTRPGPLGQKGLRISAEETVARGKATEAPKRSALS--AGARRDTSGPTPGTPSPAMARR 179 Query: 250 EELLSFMGAEEAAPDPAGVGRGGGVAGPPSGG-------GGQPQWQKCRLLLRSEGEGGG 302 G E P PA R PP+ G + + R GG Sbjct: 180 SRA---AGTEVGLPRPAPSAR----PRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGG 232 Query: 303 GSRLEFFVPPKASRPRLSIPCSSITDVR-TTTALEMPDRENTFVVKVEGPSEYIMETVDA 361 G + +S LS P S R T A P + P ++ + Sbjct: 233 GLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQ----------PKPKGLQALRP 282 Query: 362 QHVKAWVSDIQECLSPGPCPATSPRPMTLPLAPGTSFLTRENTDSLELSCLNHSESLPSQ 421 V D L P S P+ P GT D N + LP+ Sbjct: 283 PQVTPPRKDAAPALGP-----LSSSPLATPSPSGTKARPVPPPD-------NAATPLPA- 329 Query: 422 DLLLGPSESNDRLSQGAYGGLSDRPSASISPSSASIAASHFDSMELLPPELPPRIPIEEG 481 L PS + P A SPS+ S++ LP PP P + Sbjct: 330 --TLPPSPPL----------ATPLPLAPPSPSAP-------PSLQTLPS--PPATPPSQA 368 Query: 482 PPTGTVHPLSAP-----YPPLDTPETATGSFL 508 PP+ T P+ AP PP+ P + T L Sbjct: 369 PPSMTTPPMQAPPSLQTIPPIQVPHSLTSPSL 400 Score = 37.0 bits (84), Expect = 0.059 Identities = 79/297 (26%), Positives = 103/297 (34%), Gaps = 56/297 (18%) Query: 4 APSPEDGASPSSPPLPPPP--PPSWR----EFCESHARAAALDFARRFRLYLASHPQYAG 57 AP + P SP PPP PP + S + L RR P G Sbjct: 811 APFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRR--------PPTPG 862 Query: 58 PGAEAAFSRRFAELFLQHFEAEVARASGSLSPPILAPLSPGAEISPHDL-SLESCRVGGP 116 P + R L S +LS P LA S A +P +L +S GG Sbjct: 863 PDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGA 922 Query: 117 LAVLGPSRSSEDLAGPLPSSVSSSSTTSSKPKLKKRFSLRSVGRSVRGSVRGILQWRGTV 176 A P +LA P++ S P L + RG+ L W Sbjct: 923 AASPPPDA---ELAACHPAAWSRGPA----PPL-----------AFRGAPGAPLPWPPAT 964 Query: 177 DPPSS---------AGPLETSSGPPVLGGNSNSNSSGGAGTVGRGLVSDGTSPGERWTHR 227 P S+ GP + P L + +SGG G G + SP + R Sbjct: 965 GPGSADGLCTIYETEGPESATPAPGALDPGPSPGTSGGKAAAGAGAGASSRSPKQA---R 1021 Query: 228 FERLRLSRGGGALKDGAGMVQREELLS---FMGAEEAAPDPAGVGRGGGVAGPPSGG 281 L L GAL+ A +VQ LLS + A E A +G G GG G +GG Sbjct: 1022 LGELPL----GALQ--ASVVQ--HLLSRTLLLAAAEGAAGGSGGGPGGAEGGGVTGG 1070 Score = 30.8 bits (68), Expect = 4.2 Identities = 56/210 (26%), Positives = 77/210 (36%), Gaps = 29/210 (13%) Query: 2 NGAPSPEDGASPSSPPLPPPPPPSWREFCESHARAAALDFARRFRLYLASHPQYAGPGAE 61 + P P+ ++PPL PP P S + + R LA+ P P Sbjct: 719 SATPPPQAPPPLAAPPLQVPPSPP-----ASPPMSPSATPPPRVPPLLAAPPLQVPPSPP 773 Query: 62 AAFSRRFAELFLQHFEAEVARASGSL----SPPIL----APLSPGAEISPHDLSLESCRV 113 A+ + L +A A A+ L SPP AP SP A + Sbjct: 774 ASLP--MSPLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPM---------- 821 Query: 114 GGPLAVLGPSRSSEDLAGPLPSSVSSSSTTSSKPKLKKRFSLRSVGRSVRGSVRGILQWR 173 PLA P ++ LA PL V S S + +R SV G R L Sbjct: 822 -SPLAT-PPPQAPPVLAAPL-LQVPPSPPASPTLQAPRRPPTPGPDTSVSGP-RLTLALA 877 Query: 174 GTVDPPSSAGPLETSSGPPVLGGNSNSNSS 203 PP S P T SGP + G +S++ S+ Sbjct: 878 PGPPPPPSRSPSSTLSGPDLAGHSSSATST 907 >gi|4506431 RAS p21 protein activator 1 isoform 1 [Homo sapiens] Length = 1047 Score = 51.2 bits (121), Expect = 3e-06 Identities = 29/96 (30%), Positives = 47/96 (48%), Gaps = 2/96 (2%) Query: 514 EGGEGDQPLSGYPWFHGMLSRLKAAQLVLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGK 573 E G + P G WFHG +S+ +A L++T G FLVR S+ G+Y L F Sbjct: 338 EVGREEDPHEGKIWFHGKISKQEAYNLLMT--VGQVCSFLVRPSDNTPGDYSLYFRTNEN 395 Query: 574 AKHLRLSLNEEGQCRVQHLWFQSIFDMLEHFRVHPI 609 + ++ Q + ++ SI D+++H+R I Sbjct: 396 IQRFKICPTPNNQFMMGGRYYNSIGDIIDHYRKEQI 431 Score = 43.5 bits (101), Expect = 6e-04 Identities = 50/181 (27%), Positives = 79/181 (43%), Gaps = 16/181 (8%) Query: 437 GAYGGLS---DRPSASISPSSASIAASHF--DSMELLPPELPPRIPIEEGPPTGTVHPLS 491 GA GG +A ++ ++A +A + S ++ +LP + E P G PL Sbjct: 79 GALGGAGLTGGGTAAGVAGAAAGVAGAAVAGPSGDMALTKLPTSLLAETLGPGGGFPPLP 138 Query: 492 AP--YPPLDTP--ETATGSFLFQGEPEGGEGDQPLSGYP---WFHGMLSRLKAAQLVLTG 544 P PPL G L E E E PL+ P W+HG L R A + + Sbjct: 139 PPPYLPPLGAGLGTVDEGDSLDGPEYEEEEVAIPLTAPPTNQWYHGKLDRTIAEERLRQA 198 Query: 545 GTGSHGVFLVRQSETRRGEYVLTFNFQ-GKAKHLRLSLNEEGQCRVQHLWFQSIFDMLEH 603 G G +L+R+S+ R G +VL+F Q H R+ + G + F S+ D++ + Sbjct: 199 GKS--GSYLIRESDRRPGSFVLSFLSQMNVVNHFRI-IAMCGDYYIGGRRFSSLSDLIGY 255 Query: 604 F 604 + Sbjct: 256 Y 256 >gi|12545406 RAS p21 protein activator 1 isoform 2 [Homo sapiens] Length = 870 Score = 51.2 bits (121), Expect = 3e-06 Identities = 29/96 (30%), Positives = 47/96 (48%), Gaps = 2/96 (2%) Query: 514 EGGEGDQPLSGYPWFHGMLSRLKAAQLVLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGK 573 E G + P G WFHG +S+ +A L++T G FLVR S+ G+Y L F Sbjct: 161 EVGREEDPHEGKIWFHGKISKQEAYNLLMT--VGQVCSFLVRPSDNTPGDYSLYFRTNEN 218 Query: 574 AKHLRLSLNEEGQCRVQHLWFQSIFDMLEHFRVHPI 609 + ++ Q + ++ SI D+++H+R I Sbjct: 219 IQRFKICPTPNNQFMMGGRYYNSIGDIIDHYRKEQI 254 Score = 35.4 bits (80), Expect = 0.17 Identities = 23/79 (29%), Positives = 40/79 (50%), Gaps = 4/79 (5%) Query: 527 WFHGMLSRLKAAQLVLTGGTGSHGVFLVRQSETRRGEYVLTFNFQ-GKAKHLRLSLNEEG 585 W+HG L R A + + G G +L+R+S+ R G +VL+F Q H R+ + G Sbjct: 4 WYHGKLDRTIAEERLRQAGKS--GSYLIRESDRRPGSFVLSFLSQMNVVNHFRI-IAMCG 60 Query: 586 QCRVQHLWFQSIFDMLEHF 604 + F S+ D++ ++ Sbjct: 61 DYYIGGRRFSSLSDLIGYY 79 >gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo sapiens] Length = 855 Score = 50.8 bits (120), Expect = 4e-06 Identities = 108/449 (24%), Positives = 159/449 (35%), Gaps = 45/449 (10%) Query: 81 ARASGSLSPPILAPLSPGAEISPHDLSLESCRVGGPLAVLGPSRSSEDLAGPLPSSVSSS 140 AR + +P +L P PG+ P ++ + RV G +G +E G + + Sbjct: 14 ARTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGG-----IGGA 68 Query: 141 STTSSKPKLKKRFSLRSVGRSVRGSV-RGILQWRGTVDPPSSAGPLETSSGPPVLGGN-S 198 + S P+ RS G S R R RG PP+ TS GP G S Sbjct: 69 TIPESAPRAGPT---RSAGTSSRNPASRPPASGRGERAPPAK----NTSPGPVSSPGRAS 121 Query: 199 NSNSSGGAGTVGRGLVSDGTSPGERWTHRFERLRLSRGGGALKDGAGMVQREELLSFMGA 258 + G G G + ++ T + T +R LS GA +D +G + Sbjct: 122 GTTRPGPLGQKGLRISAEETVARGKATEAPKRSALS--AGARRDTSGPTPGTPSPAMARR 179 Query: 259 EEAAPDPAGVGRGGGVAGP--PSGG-------GGQPQWQKCRLLLRSEGEGGGGSRLEFF 309 AA G+ R A P P+ G + + R GGG + Sbjct: 180 SRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPAS 239 Query: 310 VPPKASRPRLSIPCSSITDVR-TTTALEMPDRENTFVVKVEGPSEYIMETVDAQHVKAWV 368 +S LS P S R T A P + ++ P + DA + Sbjct: 240 RSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPL 299 Query: 369 SDIQECLSPGPCPAT-SPRPMTLPLAPGTSFLTRENTDSLELSCLNHS-----ESLPSQD 422 S +P P A S P TLP P +S LT + L L+ + S ++LPS Sbjct: 300 SS-SPLATPSPSAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPP 358 Query: 423 LLLGPSESNDRLS----QGAYGGLSDRPSASIS-------PSSASIAASHFDSMELLPPE 471 PS++ L Q + L P + ++ P+ A S PP Sbjct: 359 AT-PPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPL 417 Query: 472 LPPRIPIEEGPPTGTVHPLSAPYPPLDTP 500 P P + P VH L AP+ P +P Sbjct: 418 SPLATPSPQAPNALAVHLLQAPFSPPPSP 446 Score = 37.7 bits (86), Expect = 0.035 Identities = 87/339 (25%), Positives = 117/339 (34%), Gaps = 82/339 (24%) Query: 4 APSPEDGASPSSPPLPPPPPPSWREFCESHARAAALDFAR---RFRLYLASHPQYAGPGA 60 +P SPS+ P P PPP A L A+ + LA+ P A P Sbjct: 484 SPPASPPMSPSATPPPQAPPP---------LAAPPLQLAKPPPQAPPALATPPLQALPSP 534 Query: 61 EAAFSRRFAELFLQHFEAEVARASGSLSPPILA-PLSPGAEISPHDLSLESCR------- 112 A+F + +PP+LA PL P +L++ R Sbjct: 535 PASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGP 594 Query: 113 ---VGGPLAVLG--------PSRS-SEDLAGPLPSSVSSSSTTSSKPKLKKRFSLRSVGR 160 V GP L PSRS S L+GP + SSS TS+ +L+ S G Sbjct: 595 DTSVSGPRLTLALAPGPPPPPSRSPSSTLSGP-DLAGHSSSATSTPEELRGYDSGPEGGA 653 Query: 161 SV--------------------------RGSVRGILQWRGTVDPPSS---------AGPL 185 + RG+ L W P S+ GP Sbjct: 654 AASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPATGPGSADGLCTIYETEGPE 713 Query: 186 ETSSGPPVLGGNSNSNSSGGAGTVGRGLVSDGTSPGERWTHRFERLRLSRGGGALKDGAG 245 + P L + +SGG G G + SP + R L L GAL+ A Sbjct: 714 SATPAPGALDPGPSPGTSGGKAAAGAGAGASSRSPKQA---RLGELPL----GALQ--AS 764 Query: 246 MVQREELLS---FMGAEEAAPDPAGVGRGGGVAGPPSGG 281 +VQ LLS + A E A +G G GG G +GG Sbjct: 765 VVQ--HLLSRTLLLAAAEGAAGGSGGGPGGAEGGGVTGG 801 Score = 30.8 bits (68), Expect = 4.2 Identities = 51/194 (26%), Positives = 66/194 (34%), Gaps = 40/194 (20%) Query: 13 PSSPPLPPPPPPSWREFCESHARAAALDFARRFRLYLASHPQYAGPGAEAAFSRRFAELF 72 P SPP PP PS ++ AA L LA P A P A Sbjct: 482 PPSPPASPPMSPSATPPPQAPPPLAAPP------LQLAKPPPQAPPA--------LATPP 527 Query: 73 LQHFEAEVARASGS--LSPPILAPLSPGAEISPHDLSLESCRVGGPLAVLGPSR-SSEDL 129 LQ + A G SP P+SP A P + + PL + PS +S L Sbjct: 528 LQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPV----LAAPLLQVPPSPPASPTL 583 Query: 130 AGPLPSSVSSSSTTSSKPKLKKRFSLRSVGRSVRGSVRGILQWRGTVDPPSSAGPLETSS 189 P T+ S P+L L PP S P T S Sbjct: 584 QAPRRPPTPGPDTSVSGPRLT-------------------LALAPGPPPPPSRSPSSTLS 624 Query: 190 GPPVLGGNSNSNSS 203 GP + G +S++ S+ Sbjct: 625 GPDLAGHSSSATST 638 >gi|117320537 phospholipase C, gamma 2 [Homo sapiens] Length = 1265 Score = 50.4 bits (119), Expect = 5e-06 Identities = 31/92 (33%), Positives = 48/92 (52%), Gaps = 12/92 (13%) Query: 524 GYPWFHGMLSRLKAAQLVL------TGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHL 577 G WFH + + +A+ +L TGG G FLVR+SET +Y L+F G+ +H Sbjct: 529 GEKWFHKKVEKRTSAEKLLQEYCMETGG--KDGTFLVRESETFPNDYTLSFWRSGRVQHC 586 Query: 578 RLSLNEEG----QCRVQHLWFQSIFDMLEHFR 605 R+ EG +L F SI+ +++H+R Sbjct: 587 RIRSTMEGGTLKYYLTDNLTFSSIYALIQHYR 618 Score = 43.1 bits (100), Expect = 8e-04 Identities = 23/89 (25%), Positives = 45/89 (50%), Gaps = 3/89 (3%) Query: 521 PLSGYPWFHGMLSRLKAAQLVLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLS 580 P PW++ LSR +A +++ G FL+R+ E Y +TF +GK KH R++ Sbjct: 640 PHESKPWYYDSLSRGEAEDMLMR--IPRDGAFLIRKREGS-DSYAITFRARGKVKHCRIN 696 Query: 581 LNEEGQCRVQHLWFQSIFDMLEHFRVHPI 609 + +F+S+ +++ ++ H + Sbjct: 697 RDGRHFVLGTSAYFESLVELVSYYEKHSL 725 >gi|33598948 phospholipase C, gamma 1 isoform a [Homo sapiens] Length = 1291 Score = 48.9 bits (115), Expect = 2e-05 Identities = 32/101 (31%), Positives = 48/101 (47%), Gaps = 16/101 (15%) Query: 523 SGYPWFHGMLS----------RLKAAQLVLTGGTGSHGVFLVRQSETRRGEYVLTFNFQG 572 S WFHG L RL + TG G FLVR+SET G+Y L+F G Sbjct: 546 SNEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPD--GSFLVRESETFVGDYTLSFWRNG 603 Query: 573 KAKHLRLSLNEEGQC----RVQHLWFQSIFDMLEHFRVHPI 609 K +H R+ ++ +L F S++D++ H++ P+ Sbjct: 604 KVQHCRIHSRQDAGTPKFFLTDNLVFDSLYDLITHYQQVPL 644 Score = 44.7 bits (104), Expect = 3e-04 Identities = 25/84 (29%), Positives = 45/84 (53%), Gaps = 6/84 (7%) Query: 527 WFHGMLSRLKAAQLVLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQ 586 W+H L+R +A +++ G FLVR+ Y ++F +GK KH R + +EGQ Sbjct: 668 WYHASLTRAQAEHMLMR--VPRDGAFLVRK-RNEPNSYAISFRAEGKIKHCR--VQQEGQ 722 Query: 587 -CRVQHLWFQSIFDMLEHFRVHPI 609 + + F S+ D++ ++ HP+ Sbjct: 723 TVMLGNSEFDSLVDLISYYEKHPL 746 >gi|33598946 phospholipase C, gamma 1 isoform b [Homo sapiens] Length = 1290 Score = 48.9 bits (115), Expect = 2e-05 Identities = 32/101 (31%), Positives = 48/101 (47%), Gaps = 16/101 (15%) Query: 523 SGYPWFHGMLS----------RLKAAQLVLTGGTGSHGVFLVRQSETRRGEYVLTFNFQG 572 S WFHG L RL + TG G FLVR+SET G+Y L+F G Sbjct: 546 SNEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPD--GSFLVRESETFVGDYTLSFWRNG 603 Query: 573 KAKHLRLSLNEEGQC----RVQHLWFQSIFDMLEHFRVHPI 609 K +H R+ ++ +L F S++D++ H++ P+ Sbjct: 604 KVQHCRIHSRQDAGTPKFFLTDNLVFDSLYDLITHYQQVPL 644 Score = 44.7 bits (104), Expect = 3e-04 Identities = 25/84 (29%), Positives = 45/84 (53%), Gaps = 6/84 (7%) Query: 527 WFHGMLSRLKAAQLVLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQ 586 W+H L+R +A +++ G FLVR+ Y ++F +GK KH R + +EGQ Sbjct: 668 WYHASLTRAQAEHMLMR--VPRDGAFLVRK-RNEPNSYAISFRAEGKIKHCR--VQQEGQ 722 Query: 587 -CRVQHLWFQSIFDMLEHFRVHPI 609 + + F S+ D++ ++ HP+ Sbjct: 723 TVMLGNSEFDSLVDLISYYEKHPL 746 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.314 0.133 0.406 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 34,773,634 Number of Sequences: 37866 Number of extensions: 2122663 Number of successful extensions: 19157 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 187 Number of HSP's successfully gapped in prelim test: 438 Number of HSP's that attempted gapping in prelim test: 15330 Number of HSP's gapped (non-prelim): 3809 length of query: 671 length of database: 18,247,518 effective HSP length: 109 effective length of query: 562 effective length of database: 14,120,124 effective search space: 7935509688 effective search space used: 7935509688 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 42 (21.9 bits) S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.