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Search of human proteins with 224831253
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|224831253 optic atrophy 1 isoform 8 [Homo sapiens]
(1015 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|224831253 optic atrophy 1 isoform 8 [Homo sapiens] 2020 0.0
gi|224831251 optic atrophy 1 isoform 7 [Homo sapiens] 1977 0.0
gi|18860841 optic atrophy 1 isoform 6 [Homo sapiens] 1935 0.0
gi|224831248 optic atrophy 1 isoform 5 [Homo sapiens] 1932 0.0
gi|224831243 optic atrophy 1 isoform 1 [Homo sapiens] 1888 0.0
gi|18860835 optic atrophy 1 isoform 4 [Homo sapiens] 1851 0.0
gi|18860833 optic atrophy 1 isoform 3 [Homo sapiens] 1847 0.0
gi|18860831 optic atrophy 1 isoform 2 [Homo sapiens] 1763 0.0
gi|56549125 dynamin 2 isoform 4 [Homo sapiens] 114 5e-25
gi|56549123 dynamin 2 isoform 2 [Homo sapiens] 114 5e-25
gi|56549121 dynamin 2 isoform 1 [Homo sapiens] 114 5e-25
gi|56549119 dynamin 2 isoform 3 [Homo sapiens] 114 5e-25
gi|56549117 dynamin 1 isoform 2 [Homo sapiens] 107 6e-23
gi|59853099 dynamin 1 isoform 1 [Homo sapiens] 107 6e-23
gi|171460914 dynamin 1-like isoform 1 [Homo sapiens] 104 4e-22
gi|171460918 dynamin 1-like isoform 3 [Homo sapiens] 104 4e-22
gi|171460916 dynamin 1-like isoform 2 [Homo sapiens] 104 4e-22
gi|42544243 dynamin 3 isoform a [Homo sapiens] 103 8e-22
gi|209915561 dynamin 3 isoform b [Homo sapiens] 103 8e-22
gi|222136619 myxovirus resistance protein 1 [Homo sapiens] 102 2e-21
gi|222136617 myxovirus resistance protein 1 [Homo sapiens] 102 2e-21
gi|11342664 myxovirus resistance protein 2 [Homo sapiens] 99 3e-20
gi|189011586 amyotrophic lateral sclerosis 2 (juvenile) chromoso... 45 5e-04
gi|116235456 ring finger protein 214 [Homo sapiens] 42 0.004
gi|116235451 ring finger protein 214 [Homo sapiens] 42 0.004
gi|94681063 bromodomain adjacent to zinc finger domain, 2B [Homo... 41 0.007
gi|224593756 hypothetical protein LOC164127 [Homo sapiens] 40 0.011
gi|56550047 uveal autoantigen with coiled-coil domains and ankyr... 40 0.011
gi|59850762 uveal autoantigen with coiled-coil domains and ankyr... 40 0.011
gi|134304846 Rb1-inducible coiled coil protein 1 isoform 2 [Homo... 39 0.025
>gi|224831253 optic atrophy 1 isoform 8 [Homo sapiens]
Length = 1015
Score = 2020 bits (5234), Expect = 0.0
Identities = 1015/1015 (100%), Positives = 1015/1015 (100%)
Query: 1 MWRLRRAAVACEVCQSLVKHSSGIKGSLPLQKLHLVSRSIYHSHHPTLKLQRPQLRTSFQ 60
MWRLRRAAVACEVCQSLVKHSSGIKGSLPLQKLHLVSRSIYHSHHPTLKLQRPQLRTSFQ
Sbjct: 1 MWRLRRAAVACEVCQSLVKHSSGIKGSLPLQKLHLVSRSIYHSHHPTLKLQRPQLRTSFQ 60
Query: 61 QFSSLTNLPLRKLKFSPIKYGYQPRRNFWPARLATRLLKLRYLILGSAVGGGYTAKKTFD 120
QFSSLTNLPLRKLKFSPIKYGYQPRRNFWPARLATRLLKLRYLILGSAVGGGYTAKKTFD
Sbjct: 61 QFSSLTNLPLRKLKFSPIKYGYQPRRNFWPARLATRLLKLRYLILGSAVGGGYTAKKTFD 120
Query: 121 QWKDMIPDLSEYKWIVPDIVWEIDEYIDFEKIRKALPSSEDLVKLAPDFDKIVESLSLLK 180
QWKDMIPDLSEYKWIVPDIVWEIDEYIDFEKIRKALPSSEDLVKLAPDFDKIVESLSLLK
Sbjct: 121 QWKDMIPDLSEYKWIVPDIVWEIDEYIDFEKIRKALPSSEDLVKLAPDFDKIVESLSLLK 180
Query: 181 DFFTSGHKLVSEVIGASDLLLLLGSPEETAFRATDRGSESDKHFRKGLLGELILLQQQIQ 240
DFFTSGHKLVSEVIGASDLLLLLGSPEETAFRATDRGSESDKHFRKGLLGELILLQQQIQ
Sbjct: 181 DFFTSGHKLVSEVIGASDLLLLLGSPEETAFRATDRGSESDKHFRKGLLGELILLQQQIQ 240
Query: 241 EHEEEARRAAGQYSTSYAQQKRKVSDKEKIDQLQEELLHTQLKYQRILERLEKENKELRK 300
EHEEEARRAAGQYSTSYAQQKRKVSDKEKIDQLQEELLHTQLKYQRILERLEKENKELRK
Sbjct: 241 EHEEEARRAAGQYSTSYAQQKRKVSDKEKIDQLQEELLHTQLKYQRILERLEKENKELRK 300
Query: 301 LVLQKDDKGIHHRKLKKSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVL 360
LVLQKDDKGIHHRKLKKSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVL
Sbjct: 301 LVLQKDDKGIHHRKLKKSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVL 360
Query: 361 EMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIEL 420
EMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIEL
Sbjct: 361 EMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIEL 420
Query: 421 RMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAY 480
RMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAY
Sbjct: 421 RMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAY 480
Query: 481 MQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQI 540
MQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQI
Sbjct: 481 MQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQI 540
Query: 541 IEGKLFPMKALGYFAVVTGKGNSSESIEAIREYEEEFFQNSKLLKTSMLKAHQVTTRNLS 600
IEGKLFPMKALGYFAVVTGKGNSSESIEAIREYEEEFFQNSKLLKTSMLKAHQVTTRNLS
Sbjct: 541 IEGKLFPMKALGYFAVVTGKGNSSESIEAIREYEEEFFQNSKLLKTSMLKAHQVTTRNLS 600
Query: 601 LAVSDCFWKMVRESVEQQADSFKATRFNLETEWKNNYPRLRELDRNELFEKAKNEILDEV 660
LAVSDCFWKMVRESVEQQADSFKATRFNLETEWKNNYPRLRELDRNELFEKAKNEILDEV
Sbjct: 601 LAVSDCFWKMVRESVEQQADSFKATRFNLETEWKNNYPRLRELDRNELFEKAKNEILDEV 660
Query: 661 ISLSQVTPKHWEEILQQSLWERVSTHVIENIYLPAAQTMNSGTFNTTVDIKLKQWTDKQL 720
ISLSQVTPKHWEEILQQSLWERVSTHVIENIYLPAAQTMNSGTFNTTVDIKLKQWTDKQL
Sbjct: 661 ISLSQVTPKHWEEILQQSLWERVSTHVIENIYLPAAQTMNSGTFNTTVDIKLKQWTDKQL 720
Query: 721 PNKAVEVAWETLQEEFSRFMTEPKGKEHDDIFDKLKEAVKEESIKRHKWNDFAEDSLRVI 780
PNKAVEVAWETLQEEFSRFMTEPKGKEHDDIFDKLKEAVKEESIKRHKWNDFAEDSLRVI
Sbjct: 721 PNKAVEVAWETLQEEFSRFMTEPKGKEHDDIFDKLKEAVKEESIKRHKWNDFAEDSLRVI 780
Query: 781 QHNALEDRSISDKQQWDAAIYFMEEALQARLKDTENAIENMVGPDWKKRWLYWKNRTQEQ 840
QHNALEDRSISDKQQWDAAIYFMEEALQARLKDTENAIENMVGPDWKKRWLYWKNRTQEQ
Sbjct: 781 QHNALEDRSISDKQQWDAAIYFMEEALQARLKDTENAIENMVGPDWKKRWLYWKNRTQEQ 840
Query: 841 CVHNETKNELEKMLKCNEEHPAYLASDEITTVRKNLESRGVEVDPSLIKDTWHQVYRRHF 900
CVHNETKNELEKMLKCNEEHPAYLASDEITTVRKNLESRGVEVDPSLIKDTWHQVYRRHF
Sbjct: 841 CVHNETKNELEKMLKCNEEHPAYLASDEITTVRKNLESRGVEVDPSLIKDTWHQVYRRHF 900
Query: 901 LKTALNHCNLCRRGFYYYQRHFVDSELECNDVVLFWRIQRMLAITANTLRQQLTNTEVRR 960
LKTALNHCNLCRRGFYYYQRHFVDSELECNDVVLFWRIQRMLAITANTLRQQLTNTEVRR
Sbjct: 901 LKTALNHCNLCRRGFYYYQRHFVDSELECNDVVLFWRIQRMLAITANTLRQQLTNTEVRR 960
Query: 961 LEKNVKEVLEDFAEDGEKKIKLLTGKRVQLAEDLKKVREIQEKLDAFIEALHQEK 1015
LEKNVKEVLEDFAEDGEKKIKLLTGKRVQLAEDLKKVREIQEKLDAFIEALHQEK
Sbjct: 961 LEKNVKEVLEDFAEDGEKKIKLLTGKRVQLAEDLKKVREIQEKLDAFIEALHQEK 1015
>gi|224831251 optic atrophy 1 isoform 7 [Homo sapiens]
Length = 997
Score = 1977 bits (5121), Expect = 0.0
Identities = 997/1015 (98%), Positives = 997/1015 (98%), Gaps = 18/1015 (1%)
Query: 1 MWRLRRAAVACEVCQSLVKHSSGIKGSLPLQKLHLVSRSIYHSHHPTLKLQRPQLRTSFQ 60
MWRLRRAAVACEVCQSLVKHSSGIKGSLPLQKLHLVSRSIYHSHHPTLKLQRPQLRTSFQ
Sbjct: 1 MWRLRRAAVACEVCQSLVKHSSGIKGSLPLQKLHLVSRSIYHSHHPTLKLQRPQLRTSFQ 60
Query: 61 QFSSLTNLPLRKLKFSPIKYGYQPRRNFWPARLATRLLKLRYLILGSAVGGGYTAKKTFD 120
QFSSLTNLPLRKLKFSPIKYGYQPRRNFWPARLATRLLKLRYLILGSAVGGGYTAKKTFD
Sbjct: 61 QFSSLTNLPLRKLKFSPIKYGYQPRRNFWPARLATRLLKLRYLILGSAVGGGYTAKKTFD 120
Query: 121 QWKDMIPDLSEYKWIVPDIVWEIDEYIDFEKIRKALPSSEDLVKLAPDFDKIVESLSLLK 180
QWKDMIPDLSEYKWIVPDIVWEIDEYIDFEKIRKALPSSEDLVKLAPDFDKIVESLSLLK
Sbjct: 121 QWKDMIPDLSEYKWIVPDIVWEIDEYIDFEKIRKALPSSEDLVKLAPDFDKIVESLSLLK 180
Query: 181 DFFTSGHKLVSEVIGASDLLLLLGSPEETAFRATDRGSESDKHFRKGLLGELILLQQQIQ 240
DFFTSG SPEETAFRATDRGSESDKHFRKGLLGELILLQQQIQ
Sbjct: 181 DFFTSG------------------SPEETAFRATDRGSESDKHFRKGLLGELILLQQQIQ 222
Query: 241 EHEEEARRAAGQYSTSYAQQKRKVSDKEKIDQLQEELLHTQLKYQRILERLEKENKELRK 300
EHEEEARRAAGQYSTSYAQQKRKVSDKEKIDQLQEELLHTQLKYQRILERLEKENKELRK
Sbjct: 223 EHEEEARRAAGQYSTSYAQQKRKVSDKEKIDQLQEELLHTQLKYQRILERLEKENKELRK 282
Query: 301 LVLQKDDKGIHHRKLKKSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVL 360
LVLQKDDKGIHHRKLKKSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVL
Sbjct: 283 LVLQKDDKGIHHRKLKKSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVL 342
Query: 361 EMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIEL 420
EMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIEL
Sbjct: 343 EMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIEL 402
Query: 421 RMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAY 480
RMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAY
Sbjct: 403 RMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAY 462
Query: 481 MQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQI 540
MQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQI
Sbjct: 463 MQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQI 522
Query: 541 IEGKLFPMKALGYFAVVTGKGNSSESIEAIREYEEEFFQNSKLLKTSMLKAHQVTTRNLS 600
IEGKLFPMKALGYFAVVTGKGNSSESIEAIREYEEEFFQNSKLLKTSMLKAHQVTTRNLS
Sbjct: 523 IEGKLFPMKALGYFAVVTGKGNSSESIEAIREYEEEFFQNSKLLKTSMLKAHQVTTRNLS 582
Query: 601 LAVSDCFWKMVRESVEQQADSFKATRFNLETEWKNNYPRLRELDRNELFEKAKNEILDEV 660
LAVSDCFWKMVRESVEQQADSFKATRFNLETEWKNNYPRLRELDRNELFEKAKNEILDEV
Sbjct: 583 LAVSDCFWKMVRESVEQQADSFKATRFNLETEWKNNYPRLRELDRNELFEKAKNEILDEV 642
Query: 661 ISLSQVTPKHWEEILQQSLWERVSTHVIENIYLPAAQTMNSGTFNTTVDIKLKQWTDKQL 720
ISLSQVTPKHWEEILQQSLWERVSTHVIENIYLPAAQTMNSGTFNTTVDIKLKQWTDKQL
Sbjct: 643 ISLSQVTPKHWEEILQQSLWERVSTHVIENIYLPAAQTMNSGTFNTTVDIKLKQWTDKQL 702
Query: 721 PNKAVEVAWETLQEEFSRFMTEPKGKEHDDIFDKLKEAVKEESIKRHKWNDFAEDSLRVI 780
PNKAVEVAWETLQEEFSRFMTEPKGKEHDDIFDKLKEAVKEESIKRHKWNDFAEDSLRVI
Sbjct: 703 PNKAVEVAWETLQEEFSRFMTEPKGKEHDDIFDKLKEAVKEESIKRHKWNDFAEDSLRVI 762
Query: 781 QHNALEDRSISDKQQWDAAIYFMEEALQARLKDTENAIENMVGPDWKKRWLYWKNRTQEQ 840
QHNALEDRSISDKQQWDAAIYFMEEALQARLKDTENAIENMVGPDWKKRWLYWKNRTQEQ
Sbjct: 763 QHNALEDRSISDKQQWDAAIYFMEEALQARLKDTENAIENMVGPDWKKRWLYWKNRTQEQ 822
Query: 841 CVHNETKNELEKMLKCNEEHPAYLASDEITTVRKNLESRGVEVDPSLIKDTWHQVYRRHF 900
CVHNETKNELEKMLKCNEEHPAYLASDEITTVRKNLESRGVEVDPSLIKDTWHQVYRRHF
Sbjct: 823 CVHNETKNELEKMLKCNEEHPAYLASDEITTVRKNLESRGVEVDPSLIKDTWHQVYRRHF 882
Query: 901 LKTALNHCNLCRRGFYYYQRHFVDSELECNDVVLFWRIQRMLAITANTLRQQLTNTEVRR 960
LKTALNHCNLCRRGFYYYQRHFVDSELECNDVVLFWRIQRMLAITANTLRQQLTNTEVRR
Sbjct: 883 LKTALNHCNLCRRGFYYYQRHFVDSELECNDVVLFWRIQRMLAITANTLRQQLTNTEVRR 942
Query: 961 LEKNVKEVLEDFAEDGEKKIKLLTGKRVQLAEDLKKVREIQEKLDAFIEALHQEK 1015
LEKNVKEVLEDFAEDGEKKIKLLTGKRVQLAEDLKKVREIQEKLDAFIEALHQEK
Sbjct: 943 LEKNVKEVLEDFAEDGEKKIKLLTGKRVQLAEDLKKVREIQEKLDAFIEALHQEK 997
>gi|18860841 optic atrophy 1 isoform 6 [Homo sapiens]
Length = 979
Score = 1935 bits (5013), Expect = 0.0
Identities = 979/1015 (96%), Positives = 979/1015 (96%), Gaps = 36/1015 (3%)
Query: 1 MWRLRRAAVACEVCQSLVKHSSGIKGSLPLQKLHLVSRSIYHSHHPTLKLQRPQLRTSFQ 60
MWRLRRAAVACEVCQSLVKHSSGIKGSLPLQKLHLVSRSIYHSHHPTLKLQRPQLRTSFQ
Sbjct: 1 MWRLRRAAVACEVCQSLVKHSSGIKGSLPLQKLHLVSRSIYHSHHPTLKLQRPQLRTSFQ 60
Query: 61 QFSSLTNLPLRKLKFSPIKYGYQPRRNFWPARLATRLLKLRYLILGSAVGGGYTAKKTFD 120
QFSSLTNLPLRKLKFSPIKYGYQPRRNFWPARLATRLLKLRYLILGSAVGGGYTAKKTFD
Sbjct: 61 QFSSLTNLPLRKLKFSPIKYGYQPRRNFWPARLATRLLKLRYLILGSAVGGGYTAKKTFD 120
Query: 121 QWKDMIPDLSEYKWIVPDIVWEIDEYIDFEKIRKALPSSEDLVKLAPDFDKIVESLSLLK 180
QWKDMIPDLSEYKWIVPDIVWEIDEYIDF
Sbjct: 121 QWKDMIPDLSEYKWIVPDIVWEIDEYIDF------------------------------- 149
Query: 181 DFFTSGHKLVSEVIGASDLLLLLGSPEETAFRATDRGSESDKHFRKGLLGELILLQQQIQ 240
GHKLVSEVIGASDLLLLLGSPEETAFRATDRGSESDKHFRKGLLGELILLQQQIQ
Sbjct: 150 -----GHKLVSEVIGASDLLLLLGSPEETAFRATDRGSESDKHFRKGLLGELILLQQQIQ 204
Query: 241 EHEEEARRAAGQYSTSYAQQKRKVSDKEKIDQLQEELLHTQLKYQRILERLEKENKELRK 300
EHEEEARRAAGQYSTSYAQQKRKVSDKEKIDQLQEELLHTQLKYQRILERLEKENKELRK
Sbjct: 205 EHEEEARRAAGQYSTSYAQQKRKVSDKEKIDQLQEELLHTQLKYQRILERLEKENKELRK 264
Query: 301 LVLQKDDKGIHHRKLKKSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVL 360
LVLQKDDKGIHHRKLKKSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVL
Sbjct: 265 LVLQKDDKGIHHRKLKKSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVL 324
Query: 361 EMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIEL 420
EMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIEL
Sbjct: 325 EMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIEL 384
Query: 421 RMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAY 480
RMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAY
Sbjct: 385 RMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAY 444
Query: 481 MQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQI 540
MQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQI
Sbjct: 445 MQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQI 504
Query: 541 IEGKLFPMKALGYFAVVTGKGNSSESIEAIREYEEEFFQNSKLLKTSMLKAHQVTTRNLS 600
IEGKLFPMKALGYFAVVTGKGNSSESIEAIREYEEEFFQNSKLLKTSMLKAHQVTTRNLS
Sbjct: 505 IEGKLFPMKALGYFAVVTGKGNSSESIEAIREYEEEFFQNSKLLKTSMLKAHQVTTRNLS 564
Query: 601 LAVSDCFWKMVRESVEQQADSFKATRFNLETEWKNNYPRLRELDRNELFEKAKNEILDEV 660
LAVSDCFWKMVRESVEQQADSFKATRFNLETEWKNNYPRLRELDRNELFEKAKNEILDEV
Sbjct: 565 LAVSDCFWKMVRESVEQQADSFKATRFNLETEWKNNYPRLRELDRNELFEKAKNEILDEV 624
Query: 661 ISLSQVTPKHWEEILQQSLWERVSTHVIENIYLPAAQTMNSGTFNTTVDIKLKQWTDKQL 720
ISLSQVTPKHWEEILQQSLWERVSTHVIENIYLPAAQTMNSGTFNTTVDIKLKQWTDKQL
Sbjct: 625 ISLSQVTPKHWEEILQQSLWERVSTHVIENIYLPAAQTMNSGTFNTTVDIKLKQWTDKQL 684
Query: 721 PNKAVEVAWETLQEEFSRFMTEPKGKEHDDIFDKLKEAVKEESIKRHKWNDFAEDSLRVI 780
PNKAVEVAWETLQEEFSRFMTEPKGKEHDDIFDKLKEAVKEESIKRHKWNDFAEDSLRVI
Sbjct: 685 PNKAVEVAWETLQEEFSRFMTEPKGKEHDDIFDKLKEAVKEESIKRHKWNDFAEDSLRVI 744
Query: 781 QHNALEDRSISDKQQWDAAIYFMEEALQARLKDTENAIENMVGPDWKKRWLYWKNRTQEQ 840
QHNALEDRSISDKQQWDAAIYFMEEALQARLKDTENAIENMVGPDWKKRWLYWKNRTQEQ
Sbjct: 745 QHNALEDRSISDKQQWDAAIYFMEEALQARLKDTENAIENMVGPDWKKRWLYWKNRTQEQ 804
Query: 841 CVHNETKNELEKMLKCNEEHPAYLASDEITTVRKNLESRGVEVDPSLIKDTWHQVYRRHF 900
CVHNETKNELEKMLKCNEEHPAYLASDEITTVRKNLESRGVEVDPSLIKDTWHQVYRRHF
Sbjct: 805 CVHNETKNELEKMLKCNEEHPAYLASDEITTVRKNLESRGVEVDPSLIKDTWHQVYRRHF 864
Query: 901 LKTALNHCNLCRRGFYYYQRHFVDSELECNDVVLFWRIQRMLAITANTLRQQLTNTEVRR 960
LKTALNHCNLCRRGFYYYQRHFVDSELECNDVVLFWRIQRMLAITANTLRQQLTNTEVRR
Sbjct: 865 LKTALNHCNLCRRGFYYYQRHFVDSELECNDVVLFWRIQRMLAITANTLRQQLTNTEVRR 924
Query: 961 LEKNVKEVLEDFAEDGEKKIKLLTGKRVQLAEDLKKVREIQEKLDAFIEALHQEK 1015
LEKNVKEVLEDFAEDGEKKIKLLTGKRVQLAEDLKKVREIQEKLDAFIEALHQEK
Sbjct: 925 LEKNVKEVLEDFAEDGEKKIKLLTGKRVQLAEDLKKVREIQEKLDAFIEALHQEK 979
>gi|224831248 optic atrophy 1 isoform 5 [Homo sapiens]
Length = 978
Score = 1932 bits (5004), Expect = 0.0
Identities = 978/1015 (96%), Positives = 978/1015 (96%), Gaps = 37/1015 (3%)
Query: 1 MWRLRRAAVACEVCQSLVKHSSGIKGSLPLQKLHLVSRSIYHSHHPTLKLQRPQLRTSFQ 60
MWRLRRAAVACEVCQSLVKHSSGIKGSLPLQKLHLVSRSIYHSHHPTLKLQRPQLRTSFQ
Sbjct: 1 MWRLRRAAVACEVCQSLVKHSSGIKGSLPLQKLHLVSRSIYHSHHPTLKLQRPQLRTSFQ 60
Query: 61 QFSSLTNLPLRKLKFSPIKYGYQPRRNFWPARLATRLLKLRYLILGSAVGGGYTAKKTFD 120
QFSSLTNLPLRKLKFSPIKYGYQPRRNFWPARLATRLLKLRYLILGSAVGGGYTAKKTFD
Sbjct: 61 QFSSLTNLPLRKLKFSPIKYGYQPRRNFWPARLATRLLKLRYLILGSAVGGGYTAKKTFD 120
Query: 121 QWKDMIPDLSEYKWIVPDIVWEIDEYIDFEKIRKALPSSEDLVKLAPDFDKIVESLSLLK 180
QWKDMIPDLSEYKWIVPDIVWEIDEYIDFEKIRKALPSSEDLVKLAPDFDKIVESLSLLK
Sbjct: 121 QWKDMIPDLSEYKWIVPDIVWEIDEYIDFEKIRKALPSSEDLVKLAPDFDKIVESLSLLK 180
Query: 181 DFFTSGHKLVSEVIGASDLLLLLGSPEETAFRATDRGSESDKHFRKGLLGELILLQQQIQ 240
DFFTSGHKLVSEVIGASDLLLLLGSPEETAFRATDRGSESDKHF
Sbjct: 181 DFFTSGHKLVSEVIGASDLLLLLGSPEETAFRATDRGSESDKHF---------------- 224
Query: 241 EHEEEARRAAGQYSTSYAQQKRKVSDKEKIDQLQEELLHTQLKYQRILERLEKENKELRK 300
RKVSDKEKIDQLQEELLHTQLKYQRILERLEKENKELRK
Sbjct: 225 ---------------------RKVSDKEKIDQLQEELLHTQLKYQRILERLEKENKELRK 263
Query: 301 LVLQKDDKGIHHRKLKKSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVL 360
LVLQKDDKGIHHRKLKKSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVL
Sbjct: 264 LVLQKDDKGIHHRKLKKSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVL 323
Query: 361 EMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIEL 420
EMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIEL
Sbjct: 324 EMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIEL 383
Query: 421 RMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAY 480
RMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAY
Sbjct: 384 RMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAY 443
Query: 481 MQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQI 540
MQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQI
Sbjct: 444 MQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQI 503
Query: 541 IEGKLFPMKALGYFAVVTGKGNSSESIEAIREYEEEFFQNSKLLKTSMLKAHQVTTRNLS 600
IEGKLFPMKALGYFAVVTGKGNSSESIEAIREYEEEFFQNSKLLKTSMLKAHQVTTRNLS
Sbjct: 504 IEGKLFPMKALGYFAVVTGKGNSSESIEAIREYEEEFFQNSKLLKTSMLKAHQVTTRNLS 563
Query: 601 LAVSDCFWKMVRESVEQQADSFKATRFNLETEWKNNYPRLRELDRNELFEKAKNEILDEV 660
LAVSDCFWKMVRESVEQQADSFKATRFNLETEWKNNYPRLRELDRNELFEKAKNEILDEV
Sbjct: 564 LAVSDCFWKMVRESVEQQADSFKATRFNLETEWKNNYPRLRELDRNELFEKAKNEILDEV 623
Query: 661 ISLSQVTPKHWEEILQQSLWERVSTHVIENIYLPAAQTMNSGTFNTTVDIKLKQWTDKQL 720
ISLSQVTPKHWEEILQQSLWERVSTHVIENIYLPAAQTMNSGTFNTTVDIKLKQWTDKQL
Sbjct: 624 ISLSQVTPKHWEEILQQSLWERVSTHVIENIYLPAAQTMNSGTFNTTVDIKLKQWTDKQL 683
Query: 721 PNKAVEVAWETLQEEFSRFMTEPKGKEHDDIFDKLKEAVKEESIKRHKWNDFAEDSLRVI 780
PNKAVEVAWETLQEEFSRFMTEPKGKEHDDIFDKLKEAVKEESIKRHKWNDFAEDSLRVI
Sbjct: 684 PNKAVEVAWETLQEEFSRFMTEPKGKEHDDIFDKLKEAVKEESIKRHKWNDFAEDSLRVI 743
Query: 781 QHNALEDRSISDKQQWDAAIYFMEEALQARLKDTENAIENMVGPDWKKRWLYWKNRTQEQ 840
QHNALEDRSISDKQQWDAAIYFMEEALQARLKDTENAIENMVGPDWKKRWLYWKNRTQEQ
Sbjct: 744 QHNALEDRSISDKQQWDAAIYFMEEALQARLKDTENAIENMVGPDWKKRWLYWKNRTQEQ 803
Query: 841 CVHNETKNELEKMLKCNEEHPAYLASDEITTVRKNLESRGVEVDPSLIKDTWHQVYRRHF 900
CVHNETKNELEKMLKCNEEHPAYLASDEITTVRKNLESRGVEVDPSLIKDTWHQVYRRHF
Sbjct: 804 CVHNETKNELEKMLKCNEEHPAYLASDEITTVRKNLESRGVEVDPSLIKDTWHQVYRRHF 863
Query: 901 LKTALNHCNLCRRGFYYYQRHFVDSELECNDVVLFWRIQRMLAITANTLRQQLTNTEVRR 960
LKTALNHCNLCRRGFYYYQRHFVDSELECNDVVLFWRIQRMLAITANTLRQQLTNTEVRR
Sbjct: 864 LKTALNHCNLCRRGFYYYQRHFVDSELECNDVVLFWRIQRMLAITANTLRQQLTNTEVRR 923
Query: 961 LEKNVKEVLEDFAEDGEKKIKLLTGKRVQLAEDLKKVREIQEKLDAFIEALHQEK 1015
LEKNVKEVLEDFAEDGEKKIKLLTGKRVQLAEDLKKVREIQEKLDAFIEALHQEK
Sbjct: 924 LEKNVKEVLEDFAEDGEKKIKLLTGKRVQLAEDLKKVREIQEKLDAFIEALHQEK 978
>gi|224831243 optic atrophy 1 isoform 1 [Homo sapiens]
Length = 960
Score = 1888 bits (4891), Expect = 0.0
Identities = 960/1015 (94%), Positives = 960/1015 (94%), Gaps = 55/1015 (5%)
Query: 1 MWRLRRAAVACEVCQSLVKHSSGIKGSLPLQKLHLVSRSIYHSHHPTLKLQRPQLRTSFQ 60
MWRLRRAAVACEVCQSLVKHSSGIKGSLPLQKLHLVSRSIYHSHHPTLKLQRPQLRTSFQ
Sbjct: 1 MWRLRRAAVACEVCQSLVKHSSGIKGSLPLQKLHLVSRSIYHSHHPTLKLQRPQLRTSFQ 60
Query: 61 QFSSLTNLPLRKLKFSPIKYGYQPRRNFWPARLATRLLKLRYLILGSAVGGGYTAKKTFD 120
QFSSLTNLPLRKLKFSPIKYGYQPRRNFWPARLATRLLKLRYLILGSAVGGGYTAKKTFD
Sbjct: 61 QFSSLTNLPLRKLKFSPIKYGYQPRRNFWPARLATRLLKLRYLILGSAVGGGYTAKKTFD 120
Query: 121 QWKDMIPDLSEYKWIVPDIVWEIDEYIDFEKIRKALPSSEDLVKLAPDFDKIVESLSLLK 180
QWKDMIPDLSEYKWIVPDIVWEIDEYIDFEKIRKALPSSEDLVKLAPDFDKIVESLSLLK
Sbjct: 121 QWKDMIPDLSEYKWIVPDIVWEIDEYIDFEKIRKALPSSEDLVKLAPDFDKIVESLSLLK 180
Query: 181 DFFTSGHKLVSEVIGASDLLLLLGSPEETAFRATDRGSESDKHFRKGLLGELILLQQQIQ 240
DFFTS GSPEETAFRATDRGSESDKHF
Sbjct: 181 DFFTS------------------GSPEETAFRATDRGSESDKHF---------------- 206
Query: 241 EHEEEARRAAGQYSTSYAQQKRKVSDKEKIDQLQEELLHTQLKYQRILERLEKENKELRK 300
RKVSDKEKIDQLQEELLHTQLKYQRILERLEKENKELRK
Sbjct: 207 ---------------------RKVSDKEKIDQLQEELLHTQLKYQRILERLEKENKELRK 245
Query: 301 LVLQKDDKGIHHRKLKKSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVL 360
LVLQKDDKGIHHRKLKKSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVL
Sbjct: 246 LVLQKDDKGIHHRKLKKSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVL 305
Query: 361 EMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIEL 420
EMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIEL
Sbjct: 306 EMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIEL 365
Query: 421 RMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAY 480
RMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAY
Sbjct: 366 RMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAY 425
Query: 481 MQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQI 540
MQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQI
Sbjct: 426 MQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQI 485
Query: 541 IEGKLFPMKALGYFAVVTGKGNSSESIEAIREYEEEFFQNSKLLKTSMLKAHQVTTRNLS 600
IEGKLFPMKALGYFAVVTGKGNSSESIEAIREYEEEFFQNSKLLKTSMLKAHQVTTRNLS
Sbjct: 486 IEGKLFPMKALGYFAVVTGKGNSSESIEAIREYEEEFFQNSKLLKTSMLKAHQVTTRNLS 545
Query: 601 LAVSDCFWKMVRESVEQQADSFKATRFNLETEWKNNYPRLRELDRNELFEKAKNEILDEV 660
LAVSDCFWKMVRESVEQQADSFKATRFNLETEWKNNYPRLRELDRNELFEKAKNEILDEV
Sbjct: 546 LAVSDCFWKMVRESVEQQADSFKATRFNLETEWKNNYPRLRELDRNELFEKAKNEILDEV 605
Query: 661 ISLSQVTPKHWEEILQQSLWERVSTHVIENIYLPAAQTMNSGTFNTTVDIKLKQWTDKQL 720
ISLSQVTPKHWEEILQQSLWERVSTHVIENIYLPAAQTMNSGTFNTTVDIKLKQWTDKQL
Sbjct: 606 ISLSQVTPKHWEEILQQSLWERVSTHVIENIYLPAAQTMNSGTFNTTVDIKLKQWTDKQL 665
Query: 721 PNKAVEVAWETLQEEFSRFMTEPKGKEHDDIFDKLKEAVKEESIKRHKWNDFAEDSLRVI 780
PNKAVEVAWETLQEEFSRFMTEPKGKEHDDIFDKLKEAVKEESIKRHKWNDFAEDSLRVI
Sbjct: 666 PNKAVEVAWETLQEEFSRFMTEPKGKEHDDIFDKLKEAVKEESIKRHKWNDFAEDSLRVI 725
Query: 781 QHNALEDRSISDKQQWDAAIYFMEEALQARLKDTENAIENMVGPDWKKRWLYWKNRTQEQ 840
QHNALEDRSISDKQQWDAAIYFMEEALQARLKDTENAIENMVGPDWKKRWLYWKNRTQEQ
Sbjct: 726 QHNALEDRSISDKQQWDAAIYFMEEALQARLKDTENAIENMVGPDWKKRWLYWKNRTQEQ 785
Query: 841 CVHNETKNELEKMLKCNEEHPAYLASDEITTVRKNLESRGVEVDPSLIKDTWHQVYRRHF 900
CVHNETKNELEKMLKCNEEHPAYLASDEITTVRKNLESRGVEVDPSLIKDTWHQVYRRHF
Sbjct: 786 CVHNETKNELEKMLKCNEEHPAYLASDEITTVRKNLESRGVEVDPSLIKDTWHQVYRRHF 845
Query: 901 LKTALNHCNLCRRGFYYYQRHFVDSELECNDVVLFWRIQRMLAITANTLRQQLTNTEVRR 960
LKTALNHCNLCRRGFYYYQRHFVDSELECNDVVLFWRIQRMLAITANTLRQQLTNTEVRR
Sbjct: 846 LKTALNHCNLCRRGFYYYQRHFVDSELECNDVVLFWRIQRMLAITANTLRQQLTNTEVRR 905
Query: 961 LEKNVKEVLEDFAEDGEKKIKLLTGKRVQLAEDLKKVREIQEKLDAFIEALHQEK 1015
LEKNVKEVLEDFAEDGEKKIKLLTGKRVQLAEDLKKVREIQEKLDAFIEALHQEK
Sbjct: 906 LEKNVKEVLEDFAEDGEKKIKLLTGKRVQLAEDLKKVREIQEKLDAFIEALHQEK 960
>gi|18860835 optic atrophy 1 isoform 4 [Homo sapiens]
Length = 961
Score = 1851 bits (4795), Expect = 0.0
Identities = 943/1015 (92%), Positives = 950/1015 (93%), Gaps = 54/1015 (5%)
Query: 1 MWRLRRAAVACEVCQSLVKHSSGIKGSLPLQKLHLVSRSIYHSHHPTLKLQRPQLRTSFQ 60
MWRLRRAAVACEVCQSLVKHSSGIKGSLPLQKLHLVSRSIYHSHHPTLKLQRPQLRTSFQ
Sbjct: 1 MWRLRRAAVACEVCQSLVKHSSGIKGSLPLQKLHLVSRSIYHSHHPTLKLQRPQLRTSFQ 60
Query: 61 QFSSLTNLPLRKLKFSPIKYGYQPRRNFWPARLATRLLKLRYLILGSAVGGGYTAKKTFD 120
QFSSLTNLPLRKLKFSPIKYGYQPRRNFWPARLATRLLKLRYLILGSAVGGGYTAKKTFD
Sbjct: 61 QFSSLTNLPLRKLKFSPIKYGYQPRRNFWPARLATRLLKLRYLILGSAVGGGYTAKKTFD 120
Query: 121 QWKDMIPDLSEYKWIVPDIVWEIDEYIDFEKIRKALPSSEDLVKLAPDFDKIVESLSLLK 180
QWKDMIP ++ EY
Sbjct: 121 QWKDMIP--------------DLSEY---------------------------------- 132
Query: 181 DFFTSGHKLVSEVIGASDLLLLLGSPEETAFRATDRGSESDKHFRKGLLGELILLQQQIQ 240
+V +++ D + GSPEETAFRATDRGSESDKHFRKGLLGELILLQQQIQ
Sbjct: 133 ------KWIVPDIVWEIDEYIDFGSPEETAFRATDRGSESDKHFRKGLLGELILLQQQIQ 186
Query: 241 EHEEEARRAAGQYSTSYAQQKRKVSDKEKIDQLQEELLHTQLKYQRILERLEKENKELRK 300
EHEEEARRAAGQYSTSYAQQKRKVSDKEKIDQLQEELLHTQLKYQRILERLEKENKELRK
Sbjct: 187 EHEEEARRAAGQYSTSYAQQKRKVSDKEKIDQLQEELLHTQLKYQRILERLEKENKELRK 246
Query: 301 LVLQKDDKGIHHRKLKKSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVL 360
LVLQKDDKGIHHRKLKKSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVL
Sbjct: 247 LVLQKDDKGIHHRKLKKSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVL 306
Query: 361 EMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIEL 420
EMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIEL
Sbjct: 307 EMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIEL 366
Query: 421 RMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAY 480
RMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAY
Sbjct: 367 RMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAY 426
Query: 481 MQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQI 540
MQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQI
Sbjct: 427 MQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQI 486
Query: 541 IEGKLFPMKALGYFAVVTGKGNSSESIEAIREYEEEFFQNSKLLKTSMLKAHQVTTRNLS 600
IEGKLFPMKALGYFAVVTGKGNSSESIEAIREYEEEFFQNSKLLKTSMLKAHQVTTRNLS
Sbjct: 487 IEGKLFPMKALGYFAVVTGKGNSSESIEAIREYEEEFFQNSKLLKTSMLKAHQVTTRNLS 546
Query: 601 LAVSDCFWKMVRESVEQQADSFKATRFNLETEWKNNYPRLRELDRNELFEKAKNEILDEV 660
LAVSDCFWKMVRESVEQQADSFKATRFNLETEWKNNYPRLRELDRNELFEKAKNEILDEV
Sbjct: 547 LAVSDCFWKMVRESVEQQADSFKATRFNLETEWKNNYPRLRELDRNELFEKAKNEILDEV 606
Query: 661 ISLSQVTPKHWEEILQQSLWERVSTHVIENIYLPAAQTMNSGTFNTTVDIKLKQWTDKQL 720
ISLSQVTPKHWEEILQQSLWERVSTHVIENIYLPAAQTMNSGTFNTTVDIKLKQWTDKQL
Sbjct: 607 ISLSQVTPKHWEEILQQSLWERVSTHVIENIYLPAAQTMNSGTFNTTVDIKLKQWTDKQL 666
Query: 721 PNKAVEVAWETLQEEFSRFMTEPKGKEHDDIFDKLKEAVKEESIKRHKWNDFAEDSLRVI 780
PNKAVEVAWETLQEEFSRFMTEPKGKEHDDIFDKLKEAVKEESIKRHKWNDFAEDSLRVI
Sbjct: 667 PNKAVEVAWETLQEEFSRFMTEPKGKEHDDIFDKLKEAVKEESIKRHKWNDFAEDSLRVI 726
Query: 781 QHNALEDRSISDKQQWDAAIYFMEEALQARLKDTENAIENMVGPDWKKRWLYWKNRTQEQ 840
QHNALEDRSISDKQQWDAAIYFMEEALQARLKDTENAIENMVGPDWKKRWLYWKNRTQEQ
Sbjct: 727 QHNALEDRSISDKQQWDAAIYFMEEALQARLKDTENAIENMVGPDWKKRWLYWKNRTQEQ 786
Query: 841 CVHNETKNELEKMLKCNEEHPAYLASDEITTVRKNLESRGVEVDPSLIKDTWHQVYRRHF 900
CVHNETKNELEKMLKCNEEHPAYLASDEITTVRKNLESRGVEVDPSLIKDTWHQVYRRHF
Sbjct: 787 CVHNETKNELEKMLKCNEEHPAYLASDEITTVRKNLESRGVEVDPSLIKDTWHQVYRRHF 846
Query: 901 LKTALNHCNLCRRGFYYYQRHFVDSELECNDVVLFWRIQRMLAITANTLRQQLTNTEVRR 960
LKTALNHCNLCRRGFYYYQRHFVDSELECNDVVLFWRIQRMLAITANTLRQQLTNTEVRR
Sbjct: 847 LKTALNHCNLCRRGFYYYQRHFVDSELECNDVVLFWRIQRMLAITANTLRQQLTNTEVRR 906
Query: 961 LEKNVKEVLEDFAEDGEKKIKLLTGKRVQLAEDLKKVREIQEKLDAFIEALHQEK 1015
LEKNVKEVLEDFAEDGEKKIKLLTGKRVQLAEDLKKVREIQEKLDAFIEALHQEK
Sbjct: 907 LEKNVKEVLEDFAEDGEKKIKLLTGKRVQLAEDLKKVREIQEKLDAFIEALHQEK 961
>gi|18860833 optic atrophy 1 isoform 3 [Homo sapiens]
Length = 942
Score = 1847 bits (4783), Expect = 0.0
Identities = 942/1015 (92%), Positives = 942/1015 (92%), Gaps = 73/1015 (7%)
Query: 1 MWRLRRAAVACEVCQSLVKHSSGIKGSLPLQKLHLVSRSIYHSHHPTLKLQRPQLRTSFQ 60
MWRLRRAAVACEVCQSLVKHSSGIKGSLPLQKLHLVSRSIYHSHHPTLKLQRPQLRTSFQ
Sbjct: 1 MWRLRRAAVACEVCQSLVKHSSGIKGSLPLQKLHLVSRSIYHSHHPTLKLQRPQLRTSFQ 60
Query: 61 QFSSLTNLPLRKLKFSPIKYGYQPRRNFWPARLATRLLKLRYLILGSAVGGGYTAKKTFD 120
QFSSLTNLPLRKLKFSPIKYGYQPRRNFWPARLATRLLKLRYLILGSAVGGGYTAKKTFD
Sbjct: 61 QFSSLTNLPLRKLKFSPIKYGYQPRRNFWPARLATRLLKLRYLILGSAVGGGYTAKKTFD 120
Query: 121 QWKDMIPDLSEYKWIVPDIVWEIDEYIDFEKIRKALPSSEDLVKLAPDFDKIVESLSLLK 180
QWKDMIPDLSEYKWIVPDIVWEIDEYIDF
Sbjct: 121 QWKDMIPDLSEYKWIVPDIVWEIDEYIDF------------------------------- 149
Query: 181 DFFTSGHKLVSEVIGASDLLLLLGSPEETAFRATDRGSESDKHFRKGLLGELILLQQQIQ 240
GHKLVSEVIGASDLLLLLGSPEETAFRATDRGSESDKHFR
Sbjct: 150 -----GHKLVSEVIGASDLLLLLGSPEETAFRATDRGSESDKHFR--------------- 189
Query: 241 EHEEEARRAAGQYSTSYAQQKRKVSDKEKIDQLQEELLHTQLKYQRILERLEKENKELRK 300
KVSDKEKIDQLQEELLHTQLKYQRILERLEKENKELRK
Sbjct: 190 ----------------------KVSDKEKIDQLQEELLHTQLKYQRILERLEKENKELRK 227
Query: 301 LVLQKDDKGIHHRKLKKSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVL 360
LVLQKDDKGIHHRKLKKSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVL
Sbjct: 228 LVLQKDDKGIHHRKLKKSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVL 287
Query: 361 EMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIEL 420
EMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIEL
Sbjct: 288 EMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIEL 347
Query: 421 RMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAY 480
RMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAY
Sbjct: 348 RMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAY 407
Query: 481 MQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQI 540
MQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQI
Sbjct: 408 MQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQI 467
Query: 541 IEGKLFPMKALGYFAVVTGKGNSSESIEAIREYEEEFFQNSKLLKTSMLKAHQVTTRNLS 600
IEGKLFPMKALGYFAVVTGKGNSSESIEAIREYEEEFFQNSKLLKTSMLKAHQVTTRNLS
Sbjct: 468 IEGKLFPMKALGYFAVVTGKGNSSESIEAIREYEEEFFQNSKLLKTSMLKAHQVTTRNLS 527
Query: 601 LAVSDCFWKMVRESVEQQADSFKATRFNLETEWKNNYPRLRELDRNELFEKAKNEILDEV 660
LAVSDCFWKMVRESVEQQADSFKATRFNLETEWKNNYPRLRELDRNELFEKAKNEILDEV
Sbjct: 528 LAVSDCFWKMVRESVEQQADSFKATRFNLETEWKNNYPRLRELDRNELFEKAKNEILDEV 587
Query: 661 ISLSQVTPKHWEEILQQSLWERVSTHVIENIYLPAAQTMNSGTFNTTVDIKLKQWTDKQL 720
ISLSQVTPKHWEEILQQSLWERVSTHVIENIYLPAAQTMNSGTFNTTVDIKLKQWTDKQL
Sbjct: 588 ISLSQVTPKHWEEILQQSLWERVSTHVIENIYLPAAQTMNSGTFNTTVDIKLKQWTDKQL 647
Query: 721 PNKAVEVAWETLQEEFSRFMTEPKGKEHDDIFDKLKEAVKEESIKRHKWNDFAEDSLRVI 780
PNKAVEVAWETLQEEFSRFMTEPKGKEHDDIFDKLKEAVKEESIKRHKWNDFAEDSLRVI
Sbjct: 648 PNKAVEVAWETLQEEFSRFMTEPKGKEHDDIFDKLKEAVKEESIKRHKWNDFAEDSLRVI 707
Query: 781 QHNALEDRSISDKQQWDAAIYFMEEALQARLKDTENAIENMVGPDWKKRWLYWKNRTQEQ 840
QHNALEDRSISDKQQWDAAIYFMEEALQARLKDTENAIENMVGPDWKKRWLYWKNRTQEQ
Sbjct: 708 QHNALEDRSISDKQQWDAAIYFMEEALQARLKDTENAIENMVGPDWKKRWLYWKNRTQEQ 767
Query: 841 CVHNETKNELEKMLKCNEEHPAYLASDEITTVRKNLESRGVEVDPSLIKDTWHQVYRRHF 900
CVHNETKNELEKMLKCNEEHPAYLASDEITTVRKNLESRGVEVDPSLIKDTWHQVYRRHF
Sbjct: 768 CVHNETKNELEKMLKCNEEHPAYLASDEITTVRKNLESRGVEVDPSLIKDTWHQVYRRHF 827
Query: 901 LKTALNHCNLCRRGFYYYQRHFVDSELECNDVVLFWRIQRMLAITANTLRQQLTNTEVRR 960
LKTALNHCNLCRRGFYYYQRHFVDSELECNDVVLFWRIQRMLAITANTLRQQLTNTEVRR
Sbjct: 828 LKTALNHCNLCRRGFYYYQRHFVDSELECNDVVLFWRIQRMLAITANTLRQQLTNTEVRR 887
Query: 961 LEKNVKEVLEDFAEDGEKKIKLLTGKRVQLAEDLKKVREIQEKLDAFIEALHQEK 1015
LEKNVKEVLEDFAEDGEKKIKLLTGKRVQLAEDLKKVREIQEKLDAFIEALHQEK
Sbjct: 888 LEKNVKEVLEDFAEDGEKKIKLLTGKRVQLAEDLKKVREIQEKLDAFIEALHQEK 942
>gi|18860831 optic atrophy 1 isoform 2 [Homo sapiens]
Length = 924
Score = 1763 bits (4565), Expect = 0.0
Identities = 906/1015 (89%), Positives = 913/1015 (89%), Gaps = 91/1015 (8%)
Query: 1 MWRLRRAAVACEVCQSLVKHSSGIKGSLPLQKLHLVSRSIYHSHHPTLKLQRPQLRTSFQ 60
MWRLRRAAVACEVCQSLVKHSSGIKGSLPLQKLHLVSRSIYHSHHPTLKLQRPQLRTSFQ
Sbjct: 1 MWRLRRAAVACEVCQSLVKHSSGIKGSLPLQKLHLVSRSIYHSHHPTLKLQRPQLRTSFQ 60
Query: 61 QFSSLTNLPLRKLKFSPIKYGYQPRRNFWPARLATRLLKLRYLILGSAVGGGYTAKKTFD 120
QFSSLTNLPLRKLKFSPIKYGYQPRRNFWPARLATRLLKLRYLILGSAVGGGYTAKKTFD
Sbjct: 61 QFSSLTNLPLRKLKFSPIKYGYQPRRNFWPARLATRLLKLRYLILGSAVGGGYTAKKTFD 120
Query: 121 QWKDMIPDLSEYKWIVPDIVWEIDEYIDFEKIRKALPSSEDLVKLAPDFDKIVESLSLLK 180
QWKDMIP ++ EY
Sbjct: 121 QWKDMIP--------------DLSEY---------------------------------- 132
Query: 181 DFFTSGHKLVSEVIGASDLLLLLGSPEETAFRATDRGSESDKHFRKGLLGELILLQQQIQ 240
+V +++ D + GSPEETAFRATDRGSESDKHFR
Sbjct: 133 ------KWIVPDIVWEIDEYIDFGSPEETAFRATDRGSESDKHFR--------------- 171
Query: 241 EHEEEARRAAGQYSTSYAQQKRKVSDKEKIDQLQEELLHTQLKYQRILERLEKENKELRK 300
KVSDKEKIDQLQEELLHTQLKYQRILERLEKENKELRK
Sbjct: 172 ----------------------KVSDKEKIDQLQEELLHTQLKYQRILERLEKENKELRK 209
Query: 301 LVLQKDDKGIHHRKLKKSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVL 360
LVLQKDDKGIHHRKLKKSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVL
Sbjct: 210 LVLQKDDKGIHHRKLKKSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVL 269
Query: 361 EMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIEL 420
EMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIEL
Sbjct: 270 EMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIEL 329
Query: 421 RMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAY 480
RMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAY
Sbjct: 330 RMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAY 389
Query: 481 MQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQI 540
MQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQI
Sbjct: 390 MQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQI 449
Query: 541 IEGKLFPMKALGYFAVVTGKGNSSESIEAIREYEEEFFQNSKLLKTSMLKAHQVTTRNLS 600
IEGKLFPMKALGYFAVVTGKGNSSESIEAIREYEEEFFQNSKLLKTSMLKAHQVTTRNLS
Sbjct: 450 IEGKLFPMKALGYFAVVTGKGNSSESIEAIREYEEEFFQNSKLLKTSMLKAHQVTTRNLS 509
Query: 601 LAVSDCFWKMVRESVEQQADSFKATRFNLETEWKNNYPRLRELDRNELFEKAKNEILDEV 660
LAVSDCFWKMVRESVEQQADSFKATRFNLETEWKNNYPRLRELDRNELFEKAKNEILDEV
Sbjct: 510 LAVSDCFWKMVRESVEQQADSFKATRFNLETEWKNNYPRLRELDRNELFEKAKNEILDEV 569
Query: 661 ISLSQVTPKHWEEILQQSLWERVSTHVIENIYLPAAQTMNSGTFNTTVDIKLKQWTDKQL 720
ISLSQVTPKHWEEILQQSLWERVSTHVIENIYLPAAQTMNSGTFNTTVDIKLKQWTDKQL
Sbjct: 570 ISLSQVTPKHWEEILQQSLWERVSTHVIENIYLPAAQTMNSGTFNTTVDIKLKQWTDKQL 629
Query: 721 PNKAVEVAWETLQEEFSRFMTEPKGKEHDDIFDKLKEAVKEESIKRHKWNDFAEDSLRVI 780
PNKAVEVAWETLQEEFSRFMTEPKGKEHDDIFDKLKEAVKEESIKRHKWNDFAEDSLRVI
Sbjct: 630 PNKAVEVAWETLQEEFSRFMTEPKGKEHDDIFDKLKEAVKEESIKRHKWNDFAEDSLRVI 689
Query: 781 QHNALEDRSISDKQQWDAAIYFMEEALQARLKDTENAIENMVGPDWKKRWLYWKNRTQEQ 840
QHNALEDRSISDKQQWDAAIYFMEEALQARLKDTENAIENMVGPDWKKRWLYWKNRTQEQ
Sbjct: 690 QHNALEDRSISDKQQWDAAIYFMEEALQARLKDTENAIENMVGPDWKKRWLYWKNRTQEQ 749
Query: 841 CVHNETKNELEKMLKCNEEHPAYLASDEITTVRKNLESRGVEVDPSLIKDTWHQVYRRHF 900
CVHNETKNELEKMLKCNEEHPAYLASDEITTVRKNLESRGVEVDPSLIKDTWHQVYRRHF
Sbjct: 750 CVHNETKNELEKMLKCNEEHPAYLASDEITTVRKNLESRGVEVDPSLIKDTWHQVYRRHF 809
Query: 901 LKTALNHCNLCRRGFYYYQRHFVDSELECNDVVLFWRIQRMLAITANTLRQQLTNTEVRR 960
LKTALNHCNLCRRGFYYYQRHFVDSELECNDVVLFWRIQRMLAITANTLRQQLTNTEVRR
Sbjct: 810 LKTALNHCNLCRRGFYYYQRHFVDSELECNDVVLFWRIQRMLAITANTLRQQLTNTEVRR 869
Query: 961 LEKNVKEVLEDFAEDGEKKIKLLTGKRVQLAEDLKKVREIQEKLDAFIEALHQEK 1015
LEKNVKEVLEDFAEDGEKKIKLLTGKRVQLAEDLKKVREIQEKLDAFIEALHQEK
Sbjct: 870 LEKNVKEVLEDFAEDGEKKIKLLTGKRVQLAEDLKKVREIQEKLDAFIEALHQEK 924
>gi|56549125 dynamin 2 isoform 4 [Homo sapiens]
Length = 866
Score = 114 bits (285), Expect = 5e-25
Identities = 89/328 (27%), Positives = 147/328 (44%), Gaps = 21/328 (6%)
Query: 317 KSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEM 376
+ LI + +++ D S S + LP++ VVG QSAGK+SVLE PRGSG +
Sbjct: 7 EELIPLVNKLQDAFSSIGQSCHLD--LPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIV 64
Query: 377 MTRSPVKVTLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIELRMRKNVKEGCTVSPET 436
R + + H S++F D +R EIE + +SP
Sbjct: 65 TRRPLILQLIFSKTEHAEFLHCKSKKFT-----DFDEVRQEIEAETDRVTGTNKGISPVP 119
Query: 437 ISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAYMQNPNAIILCIQDGSV 496
I+L V P + + L+DLPG+ PD + I + ++ +++IL + ++
Sbjct: 120 INLRVYSPHVLNLTLIDLPGITKVPVGDQPPDIEYQIKDMILQFISRESSLILAVTPANM 179
Query: 497 DAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQIIEGKLFPMKALGYFAV 556
D S L ++DP G RTI V+TK+DL ++ + + ++E KL P++ GY V
Sbjct: 180 DLANSDALKLAKEVDPQGLRTIGVITKLDLMDEGTDA----RDVLENKLLPLRR-GYIGV 234
Query: 557 VTGKGNSSE---SIEAIREYEEEFFQNSKLLKTSMLKAHQVTTRNLSLAVSDCFWKMVRE 613
V E I A E +FF + + A ++ T +L ++ +RE
Sbjct: 235 VNRSQKDIEGKKDIRAALAAERKFFLSHPAYRH---MADRMGTPHLQKTLNQQLTNHIRE 291
Query: 614 SVEQQADSFKATRFNLE---TEWKNNYP 638
S+ ++ +LE E+KN P
Sbjct: 292 SLPALRSKLQSQLLSLEKEVEEYKNFRP 319
>gi|56549123 dynamin 2 isoform 2 [Homo sapiens]
Length = 870
Score = 114 bits (285), Expect = 5e-25
Identities = 89/328 (27%), Positives = 147/328 (44%), Gaps = 21/328 (6%)
Query: 317 KSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEM 376
+ LI + +++ D S S + LP++ VVG QSAGK+SVLE PRGSG +
Sbjct: 7 EELIPLVNKLQDAFSSIGQSCHLD--LPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIV 64
Query: 377 MTRSPVKVTLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIELRMRKNVKEGCTVSPET 436
R + + H S++F D +R EIE + +SP
Sbjct: 65 TRRPLILQLIFSKTEHAEFLHCKSKKFT-----DFDEVRQEIEAETDRVTGTNKGISPVP 119
Query: 437 ISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAYMQNPNAIILCIQDGSV 496
I+L V P + + L+DLPG+ PD + I + ++ +++IL + ++
Sbjct: 120 INLRVYSPHVLNLTLIDLPGITKVPVGDQPPDIEYQIKDMILQFISRESSLILAVTPANM 179
Query: 497 DAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQIIEGKLFPMKALGYFAV 556
D S L ++DP G RTI V+TK+DL ++ + + ++E KL P++ GY V
Sbjct: 180 DLANSDALKLAKEVDPQGLRTIGVITKLDLMDEGTDA----RDVLENKLLPLRR-GYIGV 234
Query: 557 VTGKGNSSE---SIEAIREYEEEFFQNSKLLKTSMLKAHQVTTRNLSLAVSDCFWKMVRE 613
V E I A E +FF + + A ++ T +L ++ +RE
Sbjct: 235 VNRSQKDIEGKKDIRAALAAERKFFLSHPAYRH---MADRMGTPHLQKTLNQQLTNHIRE 291
Query: 614 SVEQQADSFKATRFNLE---TEWKNNYP 638
S+ ++ +LE E+KN P
Sbjct: 292 SLPALRSKLQSQLLSLEKEVEEYKNFRP 319
>gi|56549121 dynamin 2 isoform 1 [Homo sapiens]
Length = 870
Score = 114 bits (285), Expect = 5e-25
Identities = 89/328 (27%), Positives = 147/328 (44%), Gaps = 21/328 (6%)
Query: 317 KSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEM 376
+ LI + +++ D S S + LP++ VVG QSAGK+SVLE PRGSG +
Sbjct: 7 EELIPLVNKLQDAFSSIGQSCHLD--LPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIV 64
Query: 377 MTRSPVKVTLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIELRMRKNVKEGCTVSPET 436
R + + H S++F D +R EIE + +SP
Sbjct: 65 TRRPLILQLIFSKTEHAEFLHCKSKKFT-----DFDEVRQEIEAETDRVTGTNKGISPVP 119
Query: 437 ISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAYMQNPNAIILCIQDGSV 496
I+L V P + + L+DLPG+ PD + I + ++ +++IL + ++
Sbjct: 120 INLRVYSPHVLNLTLIDLPGITKVPVGDQPPDIEYQIKDMILQFISRESSLILAVTPANM 179
Query: 497 DAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQIIEGKLFPMKALGYFAV 556
D S L ++DP G RTI V+TK+DL ++ + + ++E KL P++ GY V
Sbjct: 180 DLANSDALKLAKEVDPQGLRTIGVITKLDLMDEGTDA----RDVLENKLLPLRR-GYIGV 234
Query: 557 VTGKGNSSE---SIEAIREYEEEFFQNSKLLKTSMLKAHQVTTRNLSLAVSDCFWKMVRE 613
V E I A E +FF + + A ++ T +L ++ +RE
Sbjct: 235 VNRSQKDIEGKKDIRAALAAERKFFLSHPAYRH---MADRMGTPHLQKTLNQQLTNHIRE 291
Query: 614 SVEQQADSFKATRFNLE---TEWKNNYP 638
S+ ++ +LE E+KN P
Sbjct: 292 SLPALRSKLQSQLLSLEKEVEEYKNFRP 319
>gi|56549119 dynamin 2 isoform 3 [Homo sapiens]
Length = 866
Score = 114 bits (285), Expect = 5e-25
Identities = 89/328 (27%), Positives = 147/328 (44%), Gaps = 21/328 (6%)
Query: 317 KSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEM 376
+ LI + +++ D S S + LP++ VVG QSAGK+SVLE PRGSG +
Sbjct: 7 EELIPLVNKLQDAFSSIGQSCHLD--LPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIV 64
Query: 377 MTRSPVKVTLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIELRMRKNVKEGCTVSPET 436
R + + H S++F D +R EIE + +SP
Sbjct: 65 TRRPLILQLIFSKTEHAEFLHCKSKKFT-----DFDEVRQEIEAETDRVTGTNKGISPVP 119
Query: 437 ISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAYMQNPNAIILCIQDGSV 496
I+L V P + + L+DLPG+ PD + I + ++ +++IL + ++
Sbjct: 120 INLRVYSPHVLNLTLIDLPGITKVPVGDQPPDIEYQIKDMILQFISRESSLILAVTPANM 179
Query: 497 DAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQIIEGKLFPMKALGYFAV 556
D S L ++DP G RTI V+TK+DL ++ + + ++E KL P++ GY V
Sbjct: 180 DLANSDALKLAKEVDPQGLRTIGVITKLDLMDEGTDA----RDVLENKLLPLRR-GYIGV 234
Query: 557 VTGKGNSSE---SIEAIREYEEEFFQNSKLLKTSMLKAHQVTTRNLSLAVSDCFWKMVRE 613
V E I A E +FF + + A ++ T +L ++ +RE
Sbjct: 235 VNRSQKDIEGKKDIRAALAAERKFFLSHPAYRH---MADRMGTPHLQKTLNQQLTNHIRE 291
Query: 614 SVEQQADSFKATRFNLE---TEWKNNYP 638
S+ ++ +LE E+KN P
Sbjct: 292 SLPALRSKLQSQLLSLEKEVEEYKNFRP 319
>gi|56549117 dynamin 1 isoform 2 [Homo sapiens]
Length = 851
Score = 107 bits (267), Expect = 6e-23
Identities = 80/265 (30%), Positives = 123/265 (46%), Gaps = 15/265 (5%)
Query: 317 KSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEM 376
+ LI + + + D S N LP++ VVG QSAGK+SVLE PRGSG +
Sbjct: 7 EDLIPLVNRLQDAFSAI--GQNADLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRGSG-I 63
Query: 377 MTRSPVKVTLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIELRMRKNVKEGCTVSPET 436
+TR P+ + L A F + K D +R EIE + +SP
Sbjct: 64 VTRRPLVLQLVNATTEYAEFLHCKGK----KFTDFEEVRLEIEAETDRVTGTNKGISPVP 119
Query: 437 ISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAYMQNPNAIILCIQDGSV 496
I+L V P + + LVDLPG+ PD + I + ++ N +IL + +
Sbjct: 120 INLRVYSPHVLNLTLVDLPGMTKVPVGDQPPDIEFQIRDMLMQFVTKENCLILAVSPANS 179
Query: 497 DAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQIIEGKLFPMKALGYFAV 556
D S + ++DP G+RTI V+TK+DL ++ + + ++E KL P++ GY V
Sbjct: 180 DLANSDALKVAKEVDPQGQRTIGVITKLDLMDEGTDA----RDVLENKLLPLRR-GYIGV 234
Query: 557 VTGKG---NSSESIEAIREYEEEFF 578
V + + I A E +FF
Sbjct: 235 VNRSQKDIDGKKDITAALAAERKFF 259
>gi|59853099 dynamin 1 isoform 1 [Homo sapiens]
Length = 864
Score = 107 bits (267), Expect = 6e-23
Identities = 80/265 (30%), Positives = 123/265 (46%), Gaps = 15/265 (5%)
Query: 317 KSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEM 376
+ LI + + + D S N LP++ VVG QSAGK+SVLE PRGSG +
Sbjct: 7 EDLIPLVNRLQDAFSAI--GQNADLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRGSG-I 63
Query: 377 MTRSPVKVTLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIELRMRKNVKEGCTVSPET 436
+TR P+ + L A F + K D +R EIE + +SP
Sbjct: 64 VTRRPLVLQLVNATTEYAEFLHCKGK----KFTDFEEVRLEIEAETDRVTGTNKGISPVP 119
Query: 437 ISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAYMQNPNAIILCIQDGSV 496
I+L V P + + LVDLPG+ PD + I + ++ N +IL + +
Sbjct: 120 INLRVYSPHVLNLTLVDLPGMTKVPVGDQPPDIEFQIRDMLMQFVTKENCLILAVSPANS 179
Query: 497 DAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQIIEGKLFPMKALGYFAV 556
D S + ++DP G+RTI V+TK+DL ++ + + ++E KL P++ GY V
Sbjct: 180 DLANSDALKVAKEVDPQGQRTIGVITKLDLMDEGTDA----RDVLENKLLPLRR-GYIGV 234
Query: 557 VTGKG---NSSESIEAIREYEEEFF 578
V + + I A E +FF
Sbjct: 235 VNRSQKDIDGKKDITAALAAERKFF 259
>gi|171460914 dynamin 1-like isoform 1 [Homo sapiens]
Length = 736
Score = 104 bits (260), Expect = 4e-22
Identities = 85/283 (30%), Positives = 135/283 (47%), Gaps = 34/283 (12%)
Query: 317 KSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEM 376
++LI + +++ DV + A LP++VVVG QS+GK+SVLE + + PRG+G +
Sbjct: 2 EALIPVINKLQDVFNTVGADII---QLPQIVVVGTQSSGKSSVLESLVGRDLLPRGTG-I 57
Query: 377 MTRSPVKVTLSEGPHHVALF---KDSSREFDLTKEE-------------DLAALRHEIEL 420
+TR P+ + L HV+ K + E + EE D +R EIE
Sbjct: 58 VTRRPLILQLV----HVSQEDKRKTTGEENGVEAEEWGKFLHTKNKLYTDFDEIRQEIEN 113
Query: 421 RMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAY 480
+ VSPE I L + P + + LVDLPG+ D + I + +
Sbjct: 114 ETERISGNNKGVSPEPIHLKIFSPNVVNLTLVDLPGMTKVPVGDQPKDIELQIRELILRF 173
Query: 481 MQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQI 540
+ NPN+IIL + + D S + ++DP GRRT+ V+TK+DL + + +
Sbjct: 174 ISNPNSIILAVTAANTDMATSEALKISREVDPDGRRTLAVITKLDLMDAGTDA----MDV 229
Query: 541 IEGKLFPMKALGYFAVVTGK----GNSSESIEAIREYEEEFFQ 579
+ G++ P+K LG VV N ++IR+ E F Q
Sbjct: 230 LMGRVIPVK-LGIIGVVNRSQLDINNKKSVTDSIRD-EYAFLQ 270
>gi|171460918 dynamin 1-like isoform 3 [Homo sapiens]
Length = 699
Score = 104 bits (260), Expect = 4e-22
Identities = 85/283 (30%), Positives = 135/283 (47%), Gaps = 34/283 (12%)
Query: 317 KSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEM 376
++LI + +++ DV + A LP++VVVG QS+GK+SVLE + + PRG+G +
Sbjct: 2 EALIPVINKLQDVFNTVGADII---QLPQIVVVGTQSSGKSSVLESLVGRDLLPRGTG-I 57
Query: 377 MTRSPVKVTLSEGPHHVALF---KDSSREFDLTKEE-------------DLAALRHEIEL 420
+TR P+ + L HV+ K + E + EE D +R EIE
Sbjct: 58 VTRRPLILQLV----HVSQEDKRKTTGEENGVEAEEWGKFLHTKNKLYTDFDEIRQEIEN 113
Query: 421 RMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAY 480
+ VSPE I L + P + + LVDLPG+ D + I + +
Sbjct: 114 ETERISGNNKGVSPEPIHLKIFSPNVVNLTLVDLPGMTKVPVGDQPKDIELQIRELILRF 173
Query: 481 MQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQI 540
+ NPN+IIL + + D S + ++DP GRRT+ V+TK+DL + + +
Sbjct: 174 ISNPNSIILAVTAANTDMATSEALKISREVDPDGRRTLAVITKLDLMDAGTDA----MDV 229
Query: 541 IEGKLFPMKALGYFAVVTGK----GNSSESIEAIREYEEEFFQ 579
+ G++ P+K LG VV N ++IR+ E F Q
Sbjct: 230 LMGRVIPVK-LGIIGVVNRSQLDINNKKSVTDSIRD-EYAFLQ 270
>gi|171460916 dynamin 1-like isoform 2 [Homo sapiens]
Length = 710
Score = 104 bits (260), Expect = 4e-22
Identities = 85/283 (30%), Positives = 135/283 (47%), Gaps = 34/283 (12%)
Query: 317 KSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEM 376
++LI + +++ DV + A LP++VVVG QS+GK+SVLE + + PRG+G +
Sbjct: 2 EALIPVINKLQDVFNTVGADII---QLPQIVVVGTQSSGKSSVLESLVGRDLLPRGTG-I 57
Query: 377 MTRSPVKVTLSEGPHHVALF---KDSSREFDLTKEE-------------DLAALRHEIEL 420
+TR P+ + L HV+ K + E + EE D +R EIE
Sbjct: 58 VTRRPLILQLV----HVSQEDKRKTTGEENGVEAEEWGKFLHTKNKLYTDFDEIRQEIEN 113
Query: 421 RMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAY 480
+ VSPE I L + P + + LVDLPG+ D + I + +
Sbjct: 114 ETERISGNNKGVSPEPIHLKIFSPNVVNLTLVDLPGMTKVPVGDQPKDIELQIRELILRF 173
Query: 481 MQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQI 540
+ NPN+IIL + + D S + ++DP GRRT+ V+TK+DL + + +
Sbjct: 174 ISNPNSIILAVTAANTDMATSEALKISREVDPDGRRTLAVITKLDLMDAGTDA----MDV 229
Query: 541 IEGKLFPMKALGYFAVVTGK----GNSSESIEAIREYEEEFFQ 579
+ G++ P+K LG VV N ++IR+ E F Q
Sbjct: 230 LMGRVIPVK-LGIIGVVNRSQLDINNKKSVTDSIRD-EYAFLQ 270
>gi|42544243 dynamin 3 isoform a [Homo sapiens]
Length = 863
Score = 103 bits (257), Expect = 8e-22
Identities = 88/328 (26%), Positives = 148/328 (45%), Gaps = 21/328 (6%)
Query: 317 KSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEM 376
+ LI + + + D S S + LP++ VVG QSAGK+SVLE PRGSG +
Sbjct: 7 EELIPLVNRLQDAFSALGQSCLLE--LPQIAVVGGQSAGKSSVLENFVGRDFLPRGSG-I 63
Query: 377 MTRSPVKVTLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIELRMRKNVKEGCTVSPET 436
+TR P+ + L A F + K D +R EIE + +S
Sbjct: 64 VTRRPLVLQLVTSKAEYAEFLHCKGK----KFTDFDEVRLEIEAETDRVTGMNKGISSIP 119
Query: 437 ISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAYMQNPNAIILCIQDGSV 496
I+L V P + + L+DLPG+ PD + I + ++ N +IL + +
Sbjct: 120 INLRVYSPHVLNLTLIDLPGITKVPVGDQPPDIEYQIREMIMQFITRENCLILAVTPANT 179
Query: 497 DAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQIIEGKLFPMKALGYFAV 556
D S L ++DP G RTI V+TK+DL ++ + + ++E KL P++ GY V
Sbjct: 180 DLANSDALKLAKEVDPQGLRTIGVITKLDLMDEGTDA----RDVLENKLLPLRR-GYVGV 234
Query: 557 VTGKG---NSSESIEAIREYEEEFFQNSKLLKTSMLKAHQVTTRNLSLAVSDCFWKMVRE 613
V + + I+A E +FF + + A ++ T +L ++ +R+
Sbjct: 235 VNRSQKDIDGKKDIKAAMLAERKFFLSHPAYRHI---ADRMGTPHLQKVLNQQLTNHIRD 291
Query: 614 SVEQQADSFKATRFNLETE---WKNNYP 638
++ + + ++E E +KN P
Sbjct: 292 TLPNFRNKLQGQLLSIEHEVEAYKNFKP 319
>gi|209915561 dynamin 3 isoform b [Homo sapiens]
Length = 859
Score = 103 bits (257), Expect = 8e-22
Identities = 88/328 (26%), Positives = 148/328 (45%), Gaps = 21/328 (6%)
Query: 317 KSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEM 376
+ LI + + + D S S + LP++ VVG QSAGK+SVLE PRGSG +
Sbjct: 7 EELIPLVNRLQDAFSALGQSCLLE--LPQIAVVGGQSAGKSSVLENFVGRDFLPRGSG-I 63
Query: 377 MTRSPVKVTLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIELRMRKNVKEGCTVSPET 436
+TR P+ + L A F + K D +R EIE + +S
Sbjct: 64 VTRRPLVLQLVTSKAEYAEFLHCKGK----KFTDFDEVRLEIEAETDRVTGMNKGISSIP 119
Query: 437 ISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAYMQNPNAIILCIQDGSV 496
I+L V P + + L+DLPG+ PD + I + ++ N +IL + +
Sbjct: 120 INLRVYSPHVLNLTLIDLPGITKVPVGDQPPDIEYQIREMIMQFITRENCLILAVTPANT 179
Query: 497 DAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQIIEGKLFPMKALGYFAV 556
D S L ++DP G RTI V+TK+DL ++ + + ++E KL P++ GY V
Sbjct: 180 DLANSDALKLAKEVDPQGLRTIGVITKLDLMDEGTDA----RDVLENKLLPLRR-GYVGV 234
Query: 557 VTGKG---NSSESIEAIREYEEEFFQNSKLLKTSMLKAHQVTTRNLSLAVSDCFWKMVRE 613
V + + I+A E +FF + + A ++ T +L ++ +R+
Sbjct: 235 VNRSQKDIDGKKDIKAAMLAERKFFLSHPAYRHI---ADRMGTPHLQKVLNQQLTNHIRD 291
Query: 614 SVEQQADSFKATRFNLETE---WKNNYP 638
++ + + ++E E +KN P
Sbjct: 292 TLPNFRNKLQGQLLSIEHEVEAYKNFKP 319
>gi|222136619 myxovirus resistance protein 1 [Homo sapiens]
Length = 662
Score = 102 bits (253), Expect = 2e-21
Identities = 113/478 (23%), Positives = 210/478 (43%), Gaps = 29/478 (6%)
Query: 302 VLQKDDKGIHHRKLKKSLIDMYSEVLDVLSDYDASYNTQD-HLPRVVVVGDQSAGKTSVL 360
V QK+ + L + +D++ A QD LP + V+GDQS+GK+SVL
Sbjct: 28 VAQKNPGSVAENNLCSQYEEKVRPCIDLIDSLRALGVEQDLALPAIAVIGDQSSGKSSVL 87
Query: 361 EMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVALF-KDSSREFDLTKEEDLAALRHEIE 419
E ++ + PRGSG ++TR P+ + L + + K S +++++ + D + + EI
Sbjct: 88 EALSGVAL-PRGSG-IVTRCPLVLKLKKLVNEDKWRGKVSYQDYEI-EISDASEVEKEIN 144
Query: 420 LRMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKA 479
EG +S E I+L + + + L+DLPG+ D I ++ K
Sbjct: 145 KAQNAIAGEGMGISHELITLEISSRDVPDLTLIDLPGITRVAVGNQPADIGYKIKTLIKK 204
Query: 480 YMQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQ 539
Y+Q I L + +VD + + ++DP G RTI +LTK DL +K + ++
Sbjct: 205 YIQRQETISLVVVPSNVDIATTEALSMAQEVDPEGDRTIGILTKPDLVDK--GTEDKVVD 262
Query: 540 IIEGKLFPMKALGYFAVVTGKG----NSSESIEAIREYEEEFFQNSKLLKTSMLKAHQVT 595
++ +F +K GY +V +G S+ + E+ FF+N + +L+ + T
Sbjct: 263 VVRNLVFHLKK-GYM-IVKCRGQQEIQDQLSLSEALQREKIFFENHPYFR-DLLEEGKAT 319
Query: 596 TRNLSLAVSDCFWKMVRESVEQQADSFKATRFNLETEWKNNYPRLRELDRNE----LFEK 651
L+ ++ + +S+ + K T + E + + E D NE L +K
Sbjct: 320 VPCLAEKLTSELITHICKSLPLLENQIKETHQRITEELQKYGVDIPE-DENEKMFFLIDK 378
Query: 652 AKNEILDEVISLSQVTPKHWEEILQQSLWERVSTH----VIENIYLPAAQTMNSGTFNTT 707
N ++ +L Q EE ++ R H +IEN + + + +
Sbjct: 379 V-NAFNQDITALMQGEETVGEEDIRLFTRLRHEFHKWSTIIENNFQEGHKIL-----SRK 432
Query: 708 VDIKLKQWTDKQLPNKAVEVAWETLQEEFSRFMTEPKGKEHDDIFDKLKEAVKEESIK 765
+ Q+ ++LP +ET+ ++ + + EP + D ++ A + SIK
Sbjct: 433 IQKFENQYRGRELPGFVNYRTFETIVKQQIKALEEPAVDMLHTVTDMVRLAFTDVSIK 490
>gi|222136617 myxovirus resistance protein 1 [Homo sapiens]
Length = 662
Score = 102 bits (253), Expect = 2e-21
Identities = 113/478 (23%), Positives = 210/478 (43%), Gaps = 29/478 (6%)
Query: 302 VLQKDDKGIHHRKLKKSLIDMYSEVLDVLSDYDASYNTQD-HLPRVVVVGDQSAGKTSVL 360
V QK+ + L + +D++ A QD LP + V+GDQS+GK+SVL
Sbjct: 28 VAQKNPGSVAENNLCSQYEEKVRPCIDLIDSLRALGVEQDLALPAIAVIGDQSSGKSSVL 87
Query: 361 EMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVALF-KDSSREFDLTKEEDLAALRHEIE 419
E ++ + PRGSG ++TR P+ + L + + K S +++++ + D + + EI
Sbjct: 88 EALSGVAL-PRGSG-IVTRCPLVLKLKKLVNEDKWRGKVSYQDYEI-EISDASEVEKEIN 144
Query: 420 LRMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKA 479
EG +S E I+L + + + L+DLPG+ D I ++ K
Sbjct: 145 KAQNAIAGEGMGISHELITLEISSRDVPDLTLIDLPGITRVAVGNQPADIGYKIKTLIKK 204
Query: 480 YMQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQ 539
Y+Q I L + +VD + + ++DP G RTI +LTK DL +K + ++
Sbjct: 205 YIQRQETISLVVVPSNVDIATTEALSMAQEVDPEGDRTIGILTKPDLVDK--GTEDKVVD 262
Query: 540 IIEGKLFPMKALGYFAVVTGKG----NSSESIEAIREYEEEFFQNSKLLKTSMLKAHQVT 595
++ +F +K GY +V +G S+ + E+ FF+N + +L+ + T
Sbjct: 263 VVRNLVFHLKK-GYM-IVKCRGQQEIQDQLSLSEALQREKIFFENHPYFR-DLLEEGKAT 319
Query: 596 TRNLSLAVSDCFWKMVRESVEQQADSFKATRFNLETEWKNNYPRLRELDRNE----LFEK 651
L+ ++ + +S+ + K T + E + + E D NE L +K
Sbjct: 320 VPCLAEKLTSELITHICKSLPLLENQIKETHQRITEELQKYGVDIPE-DENEKMFFLIDK 378
Query: 652 AKNEILDEVISLSQVTPKHWEEILQQSLWERVSTH----VIENIYLPAAQTMNSGTFNTT 707
N ++ +L Q EE ++ R H +IEN + + + +
Sbjct: 379 V-NAFNQDITALMQGEETVGEEDIRLFTRLRHEFHKWSTIIENNFQEGHKIL-----SRK 432
Query: 708 VDIKLKQWTDKQLPNKAVEVAWETLQEEFSRFMTEPKGKEHDDIFDKLKEAVKEESIK 765
+ Q+ ++LP +ET+ ++ + + EP + D ++ A + SIK
Sbjct: 433 IQKFENQYRGRELPGFVNYRTFETIVKQQIKALEEPAVDMLHTVTDMVRLAFTDVSIK 490
>gi|11342664 myxovirus resistance protein 2 [Homo sapiens]
Length = 715
Score = 98.6 bits (244), Expect = 3e-20
Identities = 65/214 (30%), Positives = 107/214 (50%), Gaps = 6/214 (2%)
Query: 343 LPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVALFKDSSRE 402
LP + V+GDQS+GK+SVLE ++ + PRGSG ++TR P+ + L + P + S R
Sbjct: 118 LPAIAVIGDQSSGKSSVLEALSGVAL-PRGSG-IVTRCPLVLKLKKQPCEAWAGRISYRN 175
Query: 403 FDLTKEEDLAALRHEIELRMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGVINTVT 462
+L + +D + EI G +S E ISL + P + + ++DLPG+
Sbjct: 176 TEL-ELQDPGQVEKEIHKAQNVMAGNGRGISHELISLEITSPEVPDLTIIDLPGITRVAV 234
Query: 463 SGMAPDTKETIFSISKAYMQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRTIFVLT 522
D I ++ K Y+Q I L + +VD + + ++DP G RTI +LT
Sbjct: 235 DNQPRDIGLQIKALIKKYIQRQQTINLVVVPCNVDIATTEALSMAHEVDPEGDRTIGILT 294
Query: 523 KVDLAEKNVASPSRIQQIIEGKLFPMKALGYFAV 556
K DL ++ + + ++ +P+K GY V
Sbjct: 295 KPDLMDR--GTEKSVMNVVRNLTYPLKK-GYMIV 325
>gi|189011586 amyotrophic lateral sclerosis 2 (juvenile) chromosome
region, candidate 12 isoform a [Homo sapiens]
Length = 445
Score = 44.7 bits (104), Expect = 5e-04
Identities = 53/205 (25%), Positives = 96/205 (46%), Gaps = 21/205 (10%)
Query: 116 KKTFDQWKDMIPDLSEYKWIVPDIVWEIDEYIDFEKI---RKALPSSEDLVKLAPDFDKI 172
K F ++D I D E KW W+ DE + E I +K + + ++ + KI
Sbjct: 218 KNMFRTYQDSIYDEMEEKWSKQKAKWKKDEKFERENILLQQKKKMTKKFEMESGEEDKKI 277
Query: 173 VESLS-LLKDFFTSGHKLVSEVIGASDLLLL--LGSPEETAFRATDRGSESDKHFRKGLL 229
ES S + ++F +L+ + SD L L L +E +R + ++H+ +L
Sbjct: 278 NESCSAVFENFIQEKEELLKQ--HQSDTLQLEELRKTKEVPWRR----DQINRHWHD-VL 330
Query: 230 GELILLQQQIQEHEEEA----RRAAGQYSTSYAQQKRK--VSDKEKIDQLQEELLHTQLK 283
+L+L+Q +E +A Y T QK K V + EK+ LQ + T+ K
Sbjct: 331 QQLLLMQVMQEELHAQALILESLNTNLYYTQLELQKEKAIVGNLEKM--LQTKFAETEEK 388
Query: 284 YQRILERLEKENKELRKLVLQKDDK 308
Y+ ++ L +EN L++ ++ K+++
Sbjct: 389 YKHTIQILTEENIHLKQKIISKNEE 413
>gi|116235456 ring finger protein 214 [Homo sapiens]
Length = 703
Score = 41.6 bits (96), Expect = 0.004
Identities = 38/171 (22%), Positives = 76/171 (44%), Gaps = 12/171 (7%)
Query: 196 ASDLLLLLGSPEETAFRATDRGSESDKHFRKGL---LGELILLQQQIQEHEEEARRAAGQ 252
+S L L +T F+ D +D+ K L + E LL+++ QE ++ R+ Q
Sbjct: 194 SSSLKLSQNIAVQTDFKTADSEVNTDQDIEKNLDKMMTERTLLKERYQEVLDKQRQVENQ 253
Query: 253 YSTSYAQ-QKRKVSDKEKIDQLQEELLHTQLKYQRILERLEKENKELRKLVLQKDDKGIH 311
Q Q+R+ + + ++ + + +K + +++EKE KE L ++D K
Sbjct: 254 LQVQLKQLQQRREEEMKNHQEILKAIQDVTIKREETKKKIEKEKKEF--LQKEQDLKAEI 311
Query: 312 HRKLKKSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVLEM 362
+ +K +++ LD L + D N R ++ + A K +L +
Sbjct: 312 EKLCEKGRREVWEMELDRLKNQDGEIN------RNIMEETERAWKAEILSL 356
>gi|116235451 ring finger protein 214 [Homo sapiens]
Length = 703
Score = 41.6 bits (96), Expect = 0.004
Identities = 38/171 (22%), Positives = 76/171 (44%), Gaps = 12/171 (7%)
Query: 196 ASDLLLLLGSPEETAFRATDRGSESDKHFRKGL---LGELILLQQQIQEHEEEARRAAGQ 252
+S L L +T F+ D +D+ K L + E LL+++ QE ++ R+ Q
Sbjct: 194 SSSLKLSQNIAVQTDFKTADSEVNTDQDIEKNLDKMMTERTLLKERYQEVLDKQRQVENQ 253
Query: 253 YSTSYAQ-QKRKVSDKEKIDQLQEELLHTQLKYQRILERLEKENKELRKLVLQKDDKGIH 311
Q Q+R+ + + ++ + + +K + +++EKE KE L ++D K
Sbjct: 254 LQVQLKQLQQRREEEMKNHQEILKAIQDVTIKREETKKKIEKEKKEF--LQKEQDLKAEI 311
Query: 312 HRKLKKSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVLEM 362
+ +K +++ LD L + D N R ++ + A K +L +
Sbjct: 312 EKLCEKGRREVWEMELDRLKNQDGEIN------RNIMEETERAWKAEILSL 356
>gi|94681063 bromodomain adjacent to zinc finger domain, 2B [Homo
sapiens]
Length = 2168
Score = 40.8 bits (94), Expect = 0.007
Identities = 25/92 (27%), Positives = 50/92 (54%), Gaps = 7/92 (7%)
Query: 233 ILLQQQIQEHEEEARRAAGQYSTSYAQQKRK-------VSDKEKIDQLQEELLHTQLKYQ 285
+L + Q QE A+ A Q + A++KRK + +EKI ++Q+ + +L+ Q
Sbjct: 903 LLRKLQKQEQARVAKEAKKQQAIMAAEEKRKQKEQIKIMKQQEKIKRIQQIRMEKELRAQ 962
Query: 286 RILERLEKENKELRKLVLQKDDKGIHHRKLKK 317
+ILE +K+ +E L + +K I +++++
Sbjct: 963 QILEAKKKKKEEAANAKLLEAEKRIKEKEMRR 994
>gi|224593756 hypothetical protein LOC164127 [Homo sapiens]
Length = 623
Score = 40.0 bits (92), Expect = 0.011
Identities = 36/158 (22%), Positives = 75/158 (47%), Gaps = 6/158 (3%)
Query: 216 RGSESDKHFRKGLLGELILLQQQIQEHEEEARRAAGQYSTSYAQQKRKVSD--KEKIDQL 273
R E + RK EL Q+ +E ++AR AG+ +KR + + EKI Q
Sbjct: 458 RSQEIHQGLRKERQRELREKAQKEEEQLQQARWRAGESEEQRKMRKRILVELADEKIRQA 517
Query: 274 QEELLHT---QLKYQRILERLEKENKELRKLVLQKDDKGIHHRKLKKSLIDMYSEVLDVL 330
+ + T ++++ R L L ++N + KL +K++K H +K+++ V +
Sbjct: 518 RSHVHKTTRDKVQHLRELNHLREKNHHILKLKAEKEEK-CHIEGIKEAIKKKEQRVQHIS 576
Query: 331 SDYDASYNTQDHLPRVVVVGDQSAGKTSVLEMIAQARI 368
D ++ LP+ +++ +S+ +M+ +A++
Sbjct: 577 QGKDPNFQEFQKLPQASRREERAPPNSSLDQMVLEAQL 614
>gi|56550047 uveal autoantigen with coiled-coil domains and ankyrin
repeats isoform 2 [Homo sapiens]
Length = 1403
Score = 40.0 bits (92), Expect = 0.011
Identities = 48/222 (21%), Positives = 103/222 (46%), Gaps = 20/222 (9%)
Query: 153 RKALPSSEDLVKLAPDFDKIVESLSLLK-DFFTSGHKLVSEVIGASDLLLLLGSPEETAF 211
R+ L + + +F KI + +LK + + +++ +E I ++ + S ++
Sbjct: 868 RELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMR 927
Query: 212 RATDRGSESDKHFRKGLLGELILLQQQIQEHEEEARRAAGQYSTSYA--------QQKRK 263
+ D +E ++RKG E++ L +I+ ++E YA ++K K
Sbjct: 928 KVQDSNAEILANYRKGQ-EEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKFK 986
Query: 264 VSDKEKIDQLQEELLHTQLKYQRILERLEKENKELRK--LVLQKD--DKGI---HHRKLK 316
++KE DQL E+ + + + ++ ++EN +L+K LQKD DK + +++
Sbjct: 987 ATEKELKDQLSEQTQKYSVSEEEV-KKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEME 1045
Query: 317 KSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTS 358
++L E+ L D Y ++ +V +++A +TS
Sbjct: 1046 RALSRKTDELNKQLKDLSQKYTEVKNVKEKLV--EENAKQTS 1085
Score = 37.7 bits (86), Expect = 0.055
Identities = 89/441 (20%), Positives = 173/441 (39%), Gaps = 66/441 (14%)
Query: 623 KATRFNLETEWKNNYPRLRELDRNELFEKAKNEILDEVI-SLSQVTPKHWEEILQQ---- 677
K NL E KN+Y L+ +E +K+ + I+D++ L VT K+ E+ L+
Sbjct: 717 KEQAHNLTIEMKNHYVPLKV---SEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLL 773
Query: 678 ----SLWERVSTHVIENIYLPAAQTMNSGTFNTTVDIKLKQWTDKQLPNKAVEVAWETLQ 733
SL + VS +E +++P + + ++LK+ +L K E Q
Sbjct: 774 LENDSLSKDVSR--LETVFVPPEKHEKEIIALKSNIVELKKQLS-ELKKKCGED-----Q 825
Query: 734 EEFSRFMTEPKG------------KEHDDIF----DKLKEAVKEESIKRHKWNDFAEDSL 777
E+ +E K H+++ D L + +E + K+ D ++ +
Sbjct: 826 EKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFV 885
Query: 778 RVIQHNALEDRSISDKQQWDAAIYFMEEALQARLKDTENAIENMVGPDWKKRWLYWKNRT 837
++ N + R++ + Q A Y +A++ ++ + + + Y K +
Sbjct: 886 KIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQE 945
Query: 838 QEQCVHNETK---NELEKMLKCNEEHPAYLASDEITTVRKNLESRGVEVDPSLIKDTWHQ 894
+ +H E K EL+ + +C + A + S E + ++ E+ L + T
Sbjct: 946 EIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFE--ECERKFKATEKELKDQLSEQTQKY 1003
Query: 895 VYRRHFLKTALNHCNLCRRGFYYYQRHFVDSELECNDVVLFWRIQRMLAITANTLRQQLT 954
+K + ++ + Q+ D + + ++R L+ + L +QL
Sbjct: 1004 SVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVL---IEKSHEMERALSRKTDELNKQLK 1060
Query: 955 N-----TEVRRL-----EKNVKEVLEDFA------------EDGEKKIKLLTGKRVQLAE 992
+ TEV+ + E+N K+ E A E E K L G L E
Sbjct: 1061 DLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKE 1120
Query: 993 DLKKVREIQEKLDAFIEALHQ 1013
+LK ++ EK + LHQ
Sbjct: 1121 ELKSMQRCYEKEQQTVTKLHQ 1141
>gi|59850762 uveal autoantigen with coiled-coil domains and ankyrin
repeats isoform 1 [Homo sapiens]
Length = 1416
Score = 40.0 bits (92), Expect = 0.011
Identities = 48/222 (21%), Positives = 103/222 (46%), Gaps = 20/222 (9%)
Query: 153 RKALPSSEDLVKLAPDFDKIVESLSLLK-DFFTSGHKLVSEVIGASDLLLLLGSPEETAF 211
R+ L + + +F KI + +LK + + +++ +E I ++ + S ++
Sbjct: 881 RELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMR 940
Query: 212 RATDRGSESDKHFRKGLLGELILLQQQIQEHEEEARRAAGQYSTSYA--------QQKRK 263
+ D +E ++RKG E++ L +I+ ++E YA ++K K
Sbjct: 941 KVQDSNAEILANYRKGQ-EEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKFK 999
Query: 264 VSDKEKIDQLQEELLHTQLKYQRILERLEKENKELRK--LVLQKD--DKGI---HHRKLK 316
++KE DQL E+ + + + ++ ++EN +L+K LQKD DK + +++
Sbjct: 1000 ATEKELKDQLSEQTQKYSVSEEEV-KKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEME 1058
Query: 317 KSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTS 358
++L E+ L D Y ++ +V +++A +TS
Sbjct: 1059 RALSRKTDELNKQLKDLSQKYTEVKNVKEKLV--EENAKQTS 1098
Score = 37.7 bits (86), Expect = 0.055
Identities = 89/441 (20%), Positives = 173/441 (39%), Gaps = 66/441 (14%)
Query: 623 KATRFNLETEWKNNYPRLRELDRNELFEKAKNEILDEVI-SLSQVTPKHWEEILQQ---- 677
K NL E KN+Y L+ +E +K+ + I+D++ L VT K+ E+ L+
Sbjct: 730 KEQAHNLTIEMKNHYVPLKV---SEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLL 786
Query: 678 ----SLWERVSTHVIENIYLPAAQTMNSGTFNTTVDIKLKQWTDKQLPNKAVEVAWETLQ 733
SL + VS +E +++P + + ++LK+ +L K E Q
Sbjct: 787 LENDSLSKDVSR--LETVFVPPEKHEKEIIALKSNIVELKKQLS-ELKKKCGED-----Q 838
Query: 734 EEFSRFMTEPKG------------KEHDDIF----DKLKEAVKEESIKRHKWNDFAEDSL 777
E+ +E K H+++ D L + +E + K+ D ++ +
Sbjct: 839 EKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFV 898
Query: 778 RVIQHNALEDRSISDKQQWDAAIYFMEEALQARLKDTENAIENMVGPDWKKRWLYWKNRT 837
++ N + R++ + Q A Y +A++ ++ + + + Y K +
Sbjct: 899 KIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQE 958
Query: 838 QEQCVHNETK---NELEKMLKCNEEHPAYLASDEITTVRKNLESRGVEVDPSLIKDTWHQ 894
+ +H E K EL+ + +C + A + S E + ++ E+ L + T
Sbjct: 959 EIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFE--ECERKFKATEKELKDQLSEQTQKY 1016
Query: 895 VYRRHFLKTALNHCNLCRRGFYYYQRHFVDSELECNDVVLFWRIQRMLAITANTLRQQLT 954
+K + ++ + Q+ D + + ++R L+ + L +QL
Sbjct: 1017 SVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVL---IEKSHEMERALSRKTDELNKQLK 1073
Query: 955 N-----TEVRRL-----EKNVKEVLEDFA------------EDGEKKIKLLTGKRVQLAE 992
+ TEV+ + E+N K+ E A E E K L G L E
Sbjct: 1074 DLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKE 1133
Query: 993 DLKKVREIQEKLDAFIEALHQ 1013
+LK ++ EK + LHQ
Sbjct: 1134 ELKSMQRCYEKEQQTVTKLHQ 1154
>gi|134304846 Rb1-inducible coiled coil protein 1 isoform 2 [Homo
sapiens]
Length = 1591
Score = 38.9 bits (89), Expect = 0.025
Identities = 46/243 (18%), Positives = 97/243 (39%), Gaps = 25/243 (10%)
Query: 567 IEAIREYEEEFFQNSKLLKTSMLKAHQVTTRNLSLAVSDCFWKMVRESVEQQADSFKATR 626
+ + + F+ K LK +++ LS + E + QQ + ++A
Sbjct: 1155 LNKVTSLHNQAFEIEKNLKEQIIELQSKLDSELS-----ALERQKDEKITQQEEKYEAII 1209
Query: 627 FNLETEWKNNYPRLRELDRNELFEKAKNEILDEVISLSQVTPKHWEEILQQSLWERVSTH 686
NLE + + +E DR +L +K E DE I + K E++++ L E+V
Sbjct: 1210 QNLEKD-RQKLVSSQEQDREQLIQKLNCE-KDEAIQTALKEFKLEREVVEKELLEKVKHL 1267
Query: 687 VIENIYLPAAQTMNSGTFNTTVDIKLKQWTDKQLPNKAVEVAWETLQEE----------- 735
+ PA + + + +++ K +K + +E + EE
Sbjct: 1268 ENQIAKSPAIDSTRGDSSSLVAELQEKLQEEKAKFLEQLEEQEKRKNEEMQNVRTSLIAE 1327
Query: 736 ----FSRFMTEPKGKEHD---DIFDKLKEAVKEESIKRHKWNDFAEDSLRVIQHNALEDR 788
F+ +T K ++ + D+ DKLK ++++ + +ED R+++ +
Sbjct: 1328 QQTNFNTVLTREKMRKENIINDLSDKLKSTMQQQERDKDLIESLSEDRARLLEEKKKLEE 1387
Query: 789 SIS 791
+S
Sbjct: 1388 EVS 1390
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.132 0.381
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 36,218,059
Number of Sequences: 37866
Number of extensions: 1606875
Number of successful extensions: 8692
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 78
Number of HSP's successfully gapped in prelim test: 257
Number of HSP's that attempted gapping in prelim test: 7768
Number of HSP's gapped (non-prelim): 1241
length of query: 1015
length of database: 18,247,518
effective HSP length: 112
effective length of query: 903
effective length of database: 14,006,526
effective search space: 12647892978
effective search space used: 12647892978
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.