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Search of human proteins with 224809474
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|224809474 retinoic acid induced 14 isoform b [Homo sapiens]
(951 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|224809474 retinoic acid induced 14 isoform b [Homo sapiens] 1815 0.0
gi|224809472 retinoic acid induced 14 isoform a [Homo sapiens] 1800 0.0
gi|224809470 retinoic acid induced 14 isoform a [Homo sapiens] 1800 0.0
gi|224809468 retinoic acid induced 14 isoform a [Homo sapiens] 1800 0.0
gi|224809478 retinoic acid induced 14 isoform d [Homo sapiens] 1779 0.0
gi|224809476 retinoic acid induced 14 isoform c [Homo sapiens] 1778 0.0
gi|59850762 uveal autoantigen with coiled-coil domains and ankyr... 355 9e-98
gi|56550047 uveal autoantigen with coiled-coil domains and ankyr... 351 2e-96
gi|121582655 ankyrin repeat domain 35 [Homo sapiens] 272 9e-73
gi|126723390 ankyrin repeat domain 24 [Homo sapiens] 265 2e-70
gi|239756999 PREDICTED: ankyrin repeat domain 62 [Homo sapiens] 125 1e-28
gi|239751514 PREDICTED: ankyrin repeat domain 62 isoform 4 [Homo... 125 1e-28
gi|239746016 PREDICTED: ankyrin repeat domain 62 isoform 1 [Homo... 124 3e-28
gi|38044112 restin isoform b [Homo sapiens] 118 2e-26
gi|4506751 restin isoform a [Homo sapiens] 118 2e-26
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 117 4e-26
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] 117 4e-26
gi|24233530 ankyrin repeat domain 44 [Homo sapiens] 117 5e-26
gi|62988328 ankyrin repeat domain 50 [Homo sapiens] 117 5e-26
gi|89363047 death-associated protein kinase 1 [Homo sapiens] 115 2e-25
gi|68131557 ankyrin repeat domain 28 [Homo sapiens] 113 7e-25
gi|96975023 ankyrin repeat and death domain containing 1A [Homo ... 113 1e-24
gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens] 112 2e-24
gi|116875852 HECT domain and ankyrin repeat containing, E3 ubiqu... 112 2e-24
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ... 111 4e-24
gi|239755011 PREDICTED: ankyrin repeat domain 18B [Homo sapiens] 111 4e-24
gi|239749555 PREDICTED: ankyrin repeat domain 18B [Homo sapiens] 111 4e-24
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 111 4e-24
gi|21735548 centrosomal protein 2 [Homo sapiens] 110 8e-24
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 109 1e-23
>gi|224809474 retinoic acid induced 14 isoform b [Homo sapiens]
Length = 951
Score = 1815 bits (4701), Expect = 0.0
Identities = 951/951 (100%), Positives = 951/951 (100%)
Query: 1 MKSLKAKFRKSDTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLA 60
MKSLKAKFRKSDTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLA
Sbjct: 1 MKSLKAKFRKSDTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLA 60
Query: 61 AAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGK 120
AAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGK
Sbjct: 61 AAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGK 120
Query: 121 TALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNS 180
TALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNS
Sbjct: 121 TALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNS 180
Query: 181 RNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSK 240
RNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSK
Sbjct: 181 RNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSK 240
Query: 241 ISQDADLKTPTKPKQLSDVSSPRSITSTPLSGKESVFFAEPPFKAEISSIRENKDRLSDS 300
ISQDADLKTPTKPKQLSDVSSPRSITSTPLSGKESVFFAEPPFKAEISSIRENKDRLSDS
Sbjct: 241 ISQDADLKTPTKPKQLSDVSSPRSITSTPLSGKESVFFAEPPFKAEISSIRENKDRLSDS 300
Query: 301 TTGADSLLDISSEADQQDLLSLLQAKVASLTLHNKELQDKLQAKSPKEAEADLSFDSYHS 360
TTGADSLLDISSEADQQDLLSLLQAKVASLTLHNKELQDKLQAKSPKEAEADLSFDSYHS
Sbjct: 301 TTGADSLLDISSEADQQDLLSLLQAKVASLTLHNKELQDKLQAKSPKEAEADLSFDSYHS 360
Query: 361 TQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDVRIQQLQEILQDLQKRLESSE 420
TQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDVRIQQLQEILQDLQKRLESSE
Sbjct: 361 TQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDVRIQQLQEILQDLQKRLESSE 420
Query: 421 AERKQLQVELQSRRAELVCLNNTEISENSSDLSQKLKETQSKYEEAMKEVLSVQKQMKLG 480
AERKQLQVELQSRRAELVCLNNTEISENSSDLSQKLKETQSKYEEAMKEVLSVQKQMKLG
Sbjct: 421 AERKQLQVELQSRRAELVCLNNTEISENSSDLSQKLKETQSKYEEAMKEVLSVQKQMKLG 480
Query: 481 LVSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESERNKEKVRELEEKLVEREKGTVI 540
LVSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESERNKEKVRELEEKLVEREKGTVI
Sbjct: 481 LVSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESERNKEKVRELEEKLVEREKGTVI 540
Query: 541 KPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEASDEAED 600
KPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEASDEAED
Sbjct: 541 KPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEASDEAED 600
Query: 601 MKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLEDVTAEYIHKAEHEKLMQLTN 660
MKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLEDVTAEYIHKAEHEKLMQLTN
Sbjct: 601 MKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLEDVTAEYIHKAEHEKLMQLTN 660
Query: 661 VSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSITEHLQVITTLRTAAKEMEE 720
VSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSITEHLQVITTLRTAAKEMEE
Sbjct: 661 VSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSITEHLQVITTLRTAAKEMEE 720
Query: 721 KISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASKLKE 780
KISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASKLKE
Sbjct: 721 KISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASKLKE 780
Query: 781 SVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEVNELLQKFQQAQEELAEMKRY 840
SVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEVNELLQKFQQAQEELAEMKRY
Sbjct: 781 SVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEVNELLQKFQQAQEELAEMKRY 840
Query: 841 AESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQLEALQQQVKQLQ 900
AESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQLEALQQQVKQLQ
Sbjct: 841 AESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQLEALQQQVKQLQ 900
Query: 901 NQLAECKKQHQEVISVYRMHLLYAVQGQMDEDVQKVLKQILTMCKNQSQKK 951
NQLAECKKQHQEVISVYRMHLLYAVQGQMDEDVQKVLKQILTMCKNQSQKK
Sbjct: 901 NQLAECKKQHQEVISVYRMHLLYAVQGQMDEDVQKVLKQILTMCKNQSQKK 951
>gi|224809472 retinoic acid induced 14 isoform a [Homo sapiens]
Length = 980
Score = 1800 bits (4661), Expect = 0.0
Identities = 951/980 (97%), Positives = 951/980 (97%), Gaps = 29/980 (2%)
Query: 1 MKSLKAKFRKSDTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLA 60
MKSLKAKFRKSDTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLA
Sbjct: 1 MKSLKAKFRKSDTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLA 60
Query: 61 AAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGK 120
AAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGK
Sbjct: 61 AAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGK 120
Query: 121 TALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNS 180
TALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNS
Sbjct: 121 TALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNS 180
Query: 181 RNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSK 240
RNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSK
Sbjct: 181 RNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSK 240
Query: 241 ISQDADLKTPTKPKQ-----------------------------LSDVSSPRSITSTPLS 271
ISQDADLKTPTKPKQ LSDVSSPRSITSTPLS
Sbjct: 241 ISQDADLKTPTKPKQHDQVSKISSERSGTPKKRKAPPPPISPTQLSDVSSPRSITSTPLS 300
Query: 272 GKESVFFAEPPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLT 331
GKESVFFAEPPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLT
Sbjct: 301 GKESVFFAEPPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLT 360
Query: 332 LHNKELQDKLQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSL 391
LHNKELQDKLQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSL
Sbjct: 361 LHNKELQDKLQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSL 420
Query: 392 GKSTTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSSD 451
GKSTTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSSD
Sbjct: 421 GKSTTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSSD 480
Query: 452 LSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQ 511
LSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQ
Sbjct: 481 LSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQ 540
Query: 512 NALEESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEK 571
NALEESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEK
Sbjct: 541 NALEESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEK 600
Query: 572 YQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELE 631
YQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELE
Sbjct: 601 YQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELE 660
Query: 632 DYRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLV 691
DYRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLV
Sbjct: 661 DYRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLV 720
Query: 692 DAQKENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMT 751
DAQKENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMT
Sbjct: 721 DAQKENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMT 780
Query: 752 DAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQT 811
DAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQT
Sbjct: 781 DAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQT 840
Query: 812 LLKSKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNS 871
LLKSKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNS
Sbjct: 841 LLKSKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNS 900
Query: 872 LSQLSYSTSSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQGQMDE 931
LSQLSYSTSSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQGQMDE
Sbjct: 901 LSQLSYSTSSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQGQMDE 960
Query: 932 DVQKVLKQILTMCKNQSQKK 951
DVQKVLKQILTMCKNQSQKK
Sbjct: 961 DVQKVLKQILTMCKNQSQKK 980
>gi|224809470 retinoic acid induced 14 isoform a [Homo sapiens]
Length = 980
Score = 1800 bits (4661), Expect = 0.0
Identities = 951/980 (97%), Positives = 951/980 (97%), Gaps = 29/980 (2%)
Query: 1 MKSLKAKFRKSDTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLA 60
MKSLKAKFRKSDTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLA
Sbjct: 1 MKSLKAKFRKSDTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLA 60
Query: 61 AAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGK 120
AAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGK
Sbjct: 61 AAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGK 120
Query: 121 TALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNS 180
TALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNS
Sbjct: 121 TALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNS 180
Query: 181 RNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSK 240
RNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSK
Sbjct: 181 RNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSK 240
Query: 241 ISQDADLKTPTKPKQ-----------------------------LSDVSSPRSITSTPLS 271
ISQDADLKTPTKPKQ LSDVSSPRSITSTPLS
Sbjct: 241 ISQDADLKTPTKPKQHDQVSKISSERSGTPKKRKAPPPPISPTQLSDVSSPRSITSTPLS 300
Query: 272 GKESVFFAEPPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLT 331
GKESVFFAEPPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLT
Sbjct: 301 GKESVFFAEPPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLT 360
Query: 332 LHNKELQDKLQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSL 391
LHNKELQDKLQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSL
Sbjct: 361 LHNKELQDKLQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSL 420
Query: 392 GKSTTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSSD 451
GKSTTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSSD
Sbjct: 421 GKSTTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSSD 480
Query: 452 LSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQ 511
LSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQ
Sbjct: 481 LSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQ 540
Query: 512 NALEESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEK 571
NALEESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEK
Sbjct: 541 NALEESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEK 600
Query: 572 YQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELE 631
YQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELE
Sbjct: 601 YQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELE 660
Query: 632 DYRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLV 691
DYRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLV
Sbjct: 661 DYRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLV 720
Query: 692 DAQKENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMT 751
DAQKENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMT
Sbjct: 721 DAQKENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMT 780
Query: 752 DAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQT 811
DAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQT
Sbjct: 781 DAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQT 840
Query: 812 LLKSKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNS 871
LLKSKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNS
Sbjct: 841 LLKSKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNS 900
Query: 872 LSQLSYSTSSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQGQMDE 931
LSQLSYSTSSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQGQMDE
Sbjct: 901 LSQLSYSTSSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQGQMDE 960
Query: 932 DVQKVLKQILTMCKNQSQKK 951
DVQKVLKQILTMCKNQSQKK
Sbjct: 961 DVQKVLKQILTMCKNQSQKK 980
>gi|224809468 retinoic acid induced 14 isoform a [Homo sapiens]
Length = 980
Score = 1800 bits (4661), Expect = 0.0
Identities = 951/980 (97%), Positives = 951/980 (97%), Gaps = 29/980 (2%)
Query: 1 MKSLKAKFRKSDTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLA 60
MKSLKAKFRKSDTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLA
Sbjct: 1 MKSLKAKFRKSDTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLA 60
Query: 61 AAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGK 120
AAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGK
Sbjct: 61 AAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGK 120
Query: 121 TALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNS 180
TALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNS
Sbjct: 121 TALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNS 180
Query: 181 RNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSK 240
RNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSK
Sbjct: 181 RNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSK 240
Query: 241 ISQDADLKTPTKPKQ-----------------------------LSDVSSPRSITSTPLS 271
ISQDADLKTPTKPKQ LSDVSSPRSITSTPLS
Sbjct: 241 ISQDADLKTPTKPKQHDQVSKISSERSGTPKKRKAPPPPISPTQLSDVSSPRSITSTPLS 300
Query: 272 GKESVFFAEPPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLT 331
GKESVFFAEPPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLT
Sbjct: 301 GKESVFFAEPPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLT 360
Query: 332 LHNKELQDKLQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSL 391
LHNKELQDKLQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSL
Sbjct: 361 LHNKELQDKLQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSL 420
Query: 392 GKSTTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSSD 451
GKSTTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSSD
Sbjct: 421 GKSTTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSSD 480
Query: 452 LSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQ 511
LSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQ
Sbjct: 481 LSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQ 540
Query: 512 NALEESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEK 571
NALEESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEK
Sbjct: 541 NALEESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEK 600
Query: 572 YQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELE 631
YQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELE
Sbjct: 601 YQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELE 660
Query: 632 DYRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLV 691
DYRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLV
Sbjct: 661 DYRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLV 720
Query: 692 DAQKENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMT 751
DAQKENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMT
Sbjct: 721 DAQKENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMT 780
Query: 752 DAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQT 811
DAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQT
Sbjct: 781 DAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQT 840
Query: 812 LLKSKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNS 871
LLKSKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNS
Sbjct: 841 LLKSKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNS 900
Query: 872 LSQLSYSTSSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQGQMDE 931
LSQLSYSTSSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQGQMDE
Sbjct: 901 LSQLSYSTSSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQGQMDE 960
Query: 932 DVQKVLKQILTMCKNQSQKK 951
DVQKVLKQILTMCKNQSQKK
Sbjct: 961 DVQKVLKQILTMCKNQSQKK 980
>gi|224809478 retinoic acid induced 14 isoform d [Homo sapiens]
Length = 983
Score = 1779 bits (4607), Expect = 0.0
Identities = 943/977 (96%), Positives = 944/977 (96%), Gaps = 31/977 (3%)
Query: 4 LKAKFRKSDTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAK 63
L AK +K TNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAK
Sbjct: 9 LSAKEKK--TNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAK 66
Query: 64 GHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTAL 123
GHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTAL
Sbjct: 67 GHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTAL 126
Query: 124 HYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNK 183
HYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNK
Sbjct: 127 HYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNK 186
Query: 184 SGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQ 243
SGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQ
Sbjct: 187 SGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQ 246
Query: 244 DADLKTPTKPKQ-----------------------------LSDVSSPRSITSTPLSGKE 274
DADLKTPTKPKQ LSDVSSPRSITSTPLSGKE
Sbjct: 247 DADLKTPTKPKQHDQVSKISSERSGTPKKRKAPPPPISPTQLSDVSSPRSITSTPLSGKE 306
Query: 275 SVFFAEPPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLTLHN 334
SVFFAEPPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLTLHN
Sbjct: 307 SVFFAEPPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLTLHN 366
Query: 335 KELQDKLQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKS 394
KELQDKLQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKS
Sbjct: 367 KELQDKLQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKS 426
Query: 395 TTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSSDLSQ 454
TTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSSDLSQ
Sbjct: 427 TTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSSDLSQ 486
Query: 455 KLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNAL 514
KLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNAL
Sbjct: 487 KLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNAL 546
Query: 515 EESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQE 574
EESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQE
Sbjct: 547 EESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQE 606
Query: 575 AQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYR 634
AQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYR
Sbjct: 607 AQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYR 666
Query: 635 KRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQ 694
KRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQ
Sbjct: 667 KRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQ 726
Query: 695 KENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAM 754
KENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAM
Sbjct: 727 KENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAM 786
Query: 755 VPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLK 814
VPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLK
Sbjct: 787 VPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLK 846
Query: 815 SKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQ 874
SKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQ
Sbjct: 847 SKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQ 906
Query: 875 LSYSTSSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQGQMDEDVQ 934
LSYSTSSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQGQMDEDVQ
Sbjct: 907 LSYSTSSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQGQMDEDVQ 966
Query: 935 KVLKQILTMCKNQSQKK 951
KVLKQILTMCKNQSQKK
Sbjct: 967 KVLKQILTMCKNQSQKK 983
>gi|224809476 retinoic acid induced 14 isoform c [Homo sapiens]
Length = 972
Score = 1778 bits (4604), Expect = 0.0
Identities = 939/971 (96%), Positives = 941/971 (96%), Gaps = 29/971 (2%)
Query: 10 KSDTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECL 69
++ TNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECL
Sbjct: 2 EAKTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECL 61
Query: 70 RVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQ 129
RVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQ
Sbjct: 62 RVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQ 121
Query: 130 GCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTAL 189
GCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTAL
Sbjct: 122 GCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTAL 181
Query: 190 MLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKT 249
MLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKT
Sbjct: 182 MLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKT 241
Query: 250 PTKPKQ-----------------------------LSDVSSPRSITSTPLSGKESVFFAE 280
PTKPKQ LSDVSSPRSITSTPLSGKESVFFAE
Sbjct: 242 PTKPKQHDQVSKISSERSGTPKKRKAPPPPISPTQLSDVSSPRSITSTPLSGKESVFFAE 301
Query: 281 PPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLTLHNKELQDK 340
PPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLTLHNKELQDK
Sbjct: 302 PPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLTLHNKELQDK 361
Query: 341 LQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDV 400
LQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDV
Sbjct: 362 LQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDV 421
Query: 401 RIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSSDLSQKLKETQ 460
RIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSSDLSQKLKETQ
Sbjct: 422 RIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSSDLSQKLKETQ 481
Query: 461 SKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESERN 520
SKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESERN
Sbjct: 482 SKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESERN 541
Query: 521 KEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIM 580
KEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIM
Sbjct: 542 KEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIM 601
Query: 581 KLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLE 640
KLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLE
Sbjct: 602 KLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLE 661
Query: 641 DVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVS 700
DVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVS
Sbjct: 662 DVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVS 721
Query: 701 ITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAMVPRSSY 760
ITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAMVPRSSY
Sbjct: 722 ITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAMVPRSSY 781
Query: 761 EKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEV 820
EKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEV
Sbjct: 782 EKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEV 841
Query: 821 NELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTS 880
NELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTS
Sbjct: 842 NELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTS 901
Query: 881 SSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQGQMDEDVQKVLKQI 940
SSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQGQMDEDVQKVLKQI
Sbjct: 902 SSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQGQMDEDVQKVLKQI 961
Query: 941 LTMCKNQSQKK 951
LTMCKNQSQKK
Sbjct: 962 LTMCKNQSQKK 972
>gi|59850762 uveal autoantigen with coiled-coil domains and ankyrin
repeats isoform 1 [Homo sapiens]
Length = 1416
Score = 355 bits (912), Expect = 9e-98
Identities = 302/1104 (27%), Positives = 527/1104 (47%), Gaps = 170/1104 (15%)
Query: 1 MKSLKAKFRKSDTN---------------EWNKNDDRLLQAVENGDAEKVASLLGKKGAS 45
MKSLK++ R+ D +WNK DDRL++A E GD EKV S+L KKG +
Sbjct: 1 MKSLKSRLRRQDVPGPASSGAAAASAHAADWNKYDDRLMKAAERGDVEKVTSILAKKGVN 60
Query: 46 ATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKL 105
K D EG++ FH+ +KG++ECL ++ HGVD+T DT G +ALHLAAK H C++KL
Sbjct: 61 PGKLDVEGRSVFHVVTSKGNLECLNAILIHGVDITTSDTAGRNALHLAAKYGHALCLQKL 120
Query: 106 LQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHS 165
LQ CP E D G+TALH AA C ++Q+LC+H + +N KD+DG PL+LA Q
Sbjct: 121 LQYNCPTEHADLQGRTALHDAAMADCPSSIQLLCDHGASVNAKDVDGRTPLVLATQMSRP 180
Query: 166 EICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYS 225
IC L+D GADVNSR+K RTALML CE G +AVE LIK GAD++L+D+LG+++ +Y+
Sbjct: 181 TICQLLIDRGADVNSRDKQNRTALMLGCEYGCRDAVEVLIKNGADISLLDALGHDSSYYA 240
Query: 226 KLSENAGIQSLLLS---KISQDADL--KTPT-KPKQLSDVSSPRSITSTPLSGK--ESVF 277
++ +N I +LL + ++ +L K P+ + + L+ + ++ S + + +
Sbjct: 241 RIGDNLDILTLLKTASENTNKGRELWKKGPSLQQRNLTHMQDEVNVKSHQREHQNIQDLE 300
Query: 278 FAEPPFKAEISSIRENKDRLSDSTTG------ADSLLDISSEADQQDLLSLLQAKVASLT 331
K + I++ + L D G + ++ E++++ L SLL AK
Sbjct: 301 IENEDLKERLRKIQQEQRILLDKVNGLQLQLNEEVMVADDLESEREKLKSLLAAKEKQ-- 358
Query: 332 LHNKELQDKLQAKSP-KEAEAD-LSFDSYHSTQTDLGPSLGKPGETSPPDSK-SSPSVLI 388
H + L+ K+ K E+D L S+ S + + L K G+ DS+ +SP +
Sbjct: 359 -HEESLRTIEALKNRFKYFESDHLGSGSHFSNRKE--DMLLKQGQMYMADSQCTSPGIPA 415
Query: 389 H------------SLGKSTTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAE 436
H SL T+ ++ I L++ L+ ++ ES++ +R +LQ EL + AE
Sbjct: 416 HMQSRSMLRPLELSLPSQTSYSENEI--LKKELEAMRTFCESAKQDRLKLQNELAHKVAE 473
Query: 437 --LVCLNNTEISENSSD----LSQKLKETQSKYEEAMKEVLSVQKQ---MKLGLVSPESM 487
+ L + E+S + L LK+ Q + E+ +V +Q +K L S +
Sbjct: 474 CKALALECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAAS 533
Query: 488 DNYSHFHELRVTEEEINV---------------------------------------LKQ 508
N+ EL+ +++ V L++
Sbjct: 534 GNHRLTEELKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQK 593
Query: 509 DLQNALEESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFL 568
+L E E+ KV E+E + E + P E++E MKSS + + K+ +
Sbjct: 594 ELSMCEMEREKKGRKVTEMEGQAKELSAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEM 653
Query: 569 FEKYQEAQEEIMKLK---DTLKSQMTQEAS-DEAEDMKEAMNRMIDELNKQVSELSQLYK 624
+++++ EI +LK + +K+++ Q +E E +K + + EL K+++EL+ +
Sbjct: 654 EREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKKITELTLKNQ 713
Query: 625 EAQAELED-YRKRKSLED----VTAE----YI-------HKAEHEKLMQLTNVSRAKAED 668
Q E+E Y K L++ +T E Y+ K H+ ++ N
Sbjct: 714 TLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQ 773
Query: 669 ALSEMKSQYSKVLNELTQLKQLVDAQKENSVSITEHLQVITTLRTAAKEMEEKISNLKEH 728
+E K + K+L E L + V + V +H + I L++ E+++++S LK+
Sbjct: 774 KYTEKKLEMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKK 833
Query: 729 LASKEVEVAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKV 788
+ ++ L + K M++ VP ++E+++ +L ++ +L + K+ E +
Sbjct: 834 CGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDI 893
Query: 789 HSEVVQIRSEVSQVKREKENIQTLLKS--------------------KEQEVN-ELLQKF 827
+ E V+I+ + +KR EN Q +K+ K Q+ N E+L +
Sbjct: 894 NQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANY 953
Query: 828 QQAQEEL----AEMKRYAESSSKLE-------------EDKDKKINEMSKEVTKLKEALN 870
++ QEE+ AE+K + ++ E+ ++K KE LK+ L+
Sbjct: 954 RKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKFKATEKE---LKDQLS 1010
Query: 871 SLSQ-LSYSTSSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQGQM 929
+Q S S K+ Q+ + L++++ LQ L + + + + + H + +
Sbjct: 1011 EQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRD------KTVLIEKSHEMERALSRK 1064
Query: 930 DEDVQKVLK---QILTMCKNQSQK 950
+++ K LK Q T KN +K
Sbjct: 1065 TDELNKQLKDLSQKYTEVKNVKEK 1088
Score = 228 bits (582), Expect = 2e-59
Identities = 176/660 (26%), Positives = 329/660 (49%), Gaps = 64/660 (9%)
Query: 336 ELQDKLQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKST 395
+L KL + K E L + L + + P K ++ +L +
Sbjct: 763 DLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVFVPPEKHEKEII--ALKSNI 820
Query: 396 TDNDVRIQQLQEILQDLQKRLESSEAERKQLQ-------VELQSRRAELVCLNNT----- 443
+ ++ +L++ + Q+++ + +E L+ V +++ + LN+T
Sbjct: 821 VELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTN 880
Query: 444 ----EISENSSDLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVT 499
++ + D++Q+ + + K E + + + Q Q+K +S HE +++
Sbjct: 881 RELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAE-------HEAKMS 933
Query: 500 EEEINVLKQDLQNA--LEESERNKEKVREL--EEKLVEREKGTVIK------PPVEEYEE 549
++ K NA L + +E++ L E K ++E T+ + P+ +EE
Sbjct: 934 SLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEE 993
Query: 550 MKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLK---DTLKSQMTQEASD---------E 597
+ + + + + + + +KY ++EE+ K K D LK ++ D +
Sbjct: 994 CERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEK 1053
Query: 598 AEDMKEAMNRMIDELNKQVSELSQLY---KEAQAELEDYRKRKSLEDVTAEYIHKAEHEK 654
+ +M+ A++R DELNKQ+ +LSQ Y K + +L + +++ E + + + + +H
Sbjct: 1054 SHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVP 1113
Query: 655 LMQLTNVSRA------KAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSITEHLQVI 708
L Q+ + ++ ++ L M+ Y K +T+L QL++ QK +SV + EHLQ+
Sbjct: 1114 LEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIK 1173
Query: 709 TTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAM----TDAMVPRSSYEKLQ 764
++ + +E +K EV+KL+ ++ K A+ T +V S Y+ +
Sbjct: 1174 EAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDLSKYKATK 1233
Query: 765 SSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEVNELL 824
S LE+++S L KL ++ E+V EV+ + + K EKE + S EQE+ +
Sbjct: 1234 SDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKELLHF---SIEQEIKDQK 1290
Query: 825 QKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTSS-SK 883
++ ++ + E++R + S+K E KD KI E+ +V +LK+ALN LSQL+Y++ + +K
Sbjct: 1291 ERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTYTSGNPTK 1350
Query: 884 RQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQGQMDEDVQKVLKQILTM 943
RQSQ ++ LQ QVK L+ QLA+ +QHQEVI++YR HLL A QG MDEDVQ+ L QI+ M
Sbjct: 1351 RQSQLIDTLQHQVKSLEQQLADADRQHQEVIAIYRTHLLSAAQGHMDEDVQEALLQIIQM 1410
>gi|56550047 uveal autoantigen with coiled-coil domains and ankyrin
repeats isoform 2 [Homo sapiens]
Length = 1403
Score = 351 bits (901), Expect = 2e-96
Identities = 295/1075 (27%), Positives = 517/1075 (48%), Gaps = 155/1075 (14%)
Query: 15 EWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMIT 74
+WNK DDRL++A E GD EKV S+L KKG + K D EG++ FH+ +KG++ECL ++
Sbjct: 17 DWNKYDDRLMKAAERGDVEKVTSILAKKGVNPGKLDVEGRSVFHVVTSKGNLECLNAILI 76
Query: 75 HGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQA 134
HGVD+T DT G +ALHLAAK H C++KLLQ CP E D G+TALH AA C +
Sbjct: 77 HGVDITTSDTAGRNALHLAAKYGHALCLQKLLQYNCPTEHADLQGRTALHDAAMADCPSS 136
Query: 135 VQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACE 194
+Q+LC+H + +N KD+DG PL+LA Q IC L+D GADVNSR+K RTALML CE
Sbjct: 137 IQLLCDHGASVNAKDVDGRTPLVLATQMSRPTICQLLIDRGADVNSRDKQNRTALMLGCE 196
Query: 195 IGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLS---KISQDADL--KT 249
G +AVE LIK GAD++L+D+LG+++ +Y+++ +N I +LL + ++ +L K
Sbjct: 197 YGCRDAVEVLIKNGADISLLDALGHDSSYYARIGDNLDILTLLKTASENTNKGRELWKKG 256
Query: 250 PT-KPKQLSDVSSPRSITSTPLSGK--ESVFFAEPPFKAEISSIRENKDRLSDSTTG--- 303
P+ + + L+ + ++ S + + + K + I++ + L D G
Sbjct: 257 PSLQQRNLTHMQDEVNVKSHQREHQNIQDLEIENEDLKERLRKIQQEQRILLDKVNGLQL 316
Query: 304 ---ADSLLDISSEADQQDLLSLLQAKVASLTLHNKELQDKLQAKSP-KEAEAD-LSFDSY 358
+ ++ E++++ L SLL AK H + L+ K+ K E+D L S+
Sbjct: 317 QLNEEVMVADDLESEREKLKSLLAAKEKQ---HEESLRTIEALKNRFKYFESDHLGSGSH 373
Query: 359 HSTQTDLGPSLGKPGETSPPDSK-SSPSVLIH------------SLGKSTTDNDVRIQQL 405
S + + L K G+ DS+ +SP + H SL T+ ++ I L
Sbjct: 374 FSNRKE--DMLLKQGQMYMADSQCTSPGIPAHMQSRSMLRPLELSLPSQTSYSENEI--L 429
Query: 406 QEILQDLQKRLESSEAERKQLQVELQSRRAE--LVCLNNTEISENSSD----LSQKLKET 459
++ L+ ++ ES++ +R +LQ EL + AE + L + E+S + L LK+
Sbjct: 430 KKELEAMRTFCESAKQDRLKLQNELAHKVAECKALALECERVKEDSDEQIKQLEDALKDV 489
Query: 460 QSKYEEAMKEVLSVQKQ---MKLGLVSPESMDNYSHFHELRVTEEEINV----------- 505
Q + E+ +V +Q +K L S + N+ EL+ +++ V
Sbjct: 490 QKRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLTEELKDQLKDLKVKYEGASAEVGK 549
Query: 506 ----------------------------LKQDLQNALEESERNKEKVRELEEKLVEREKG 537
L+++L E E+ KV E+E + E
Sbjct: 550 LRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAK 609
Query: 538 TVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLK---DTLKSQMTQEA 594
+ P E++E MKSS + + K+ + +++++ EI +LK + +K+++ Q
Sbjct: 610 LALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHV 669
Query: 595 S-DEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELED-YRKRKSLED----VTAE--- 645
+E E +K + + EL K+++EL+ + Q E+E Y K L++ +T E
Sbjct: 670 KPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKN 729
Query: 646 -YI-------HKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKEN 697
Y+ K H+ ++ N +E K + K+L E L + V +
Sbjct: 730 HYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETV 789
Query: 698 SVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAMVPR 757
V +H + I L++ E+++++S LK+ + ++ L + K M++ VP
Sbjct: 790 FVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPV 849
Query: 758 SSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKS-- 815
++E+++ +L ++ +L + K+ E ++ E V+I+ + +KR EN Q +K+
Sbjct: 850 KTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEY 909
Query: 816 ------------------KEQEVN-ELLQKFQQAQEEL----AEMKRYAESSSKLE---- 848
K Q+ N E+L +++ QEE+ AE+K + ++
Sbjct: 910 ISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIK 969
Query: 849 ---------EDKDKKINEMSKEVTKLKEALNSLSQ-LSYSTSSSKRQSQQLEALQQQVKQ 898
E+ ++K KE LK+ L+ +Q S S K+ Q+ + L++++
Sbjct: 970 VKYAPIVSFEECERKFKATEKE---LKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFT 1026
Query: 899 LQNQLAECKKQHQEVISVYRMHLLYAVQGQMDEDVQKVLK---QILTMCKNQSQK 950
LQ L + + + + + H + + +++ K LK Q T KN +K
Sbjct: 1027 LQKDLRD------KTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEK 1075
Score = 228 bits (582), Expect = 2e-59
Identities = 176/660 (26%), Positives = 329/660 (49%), Gaps = 64/660 (9%)
Query: 336 ELQDKLQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKST 395
+L KL + K E L + L + + P K ++ +L +
Sbjct: 750 DLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVFVPPEKHEKEII--ALKSNI 807
Query: 396 TDNDVRIQQLQEILQDLQKRLESSEAERKQLQ-------VELQSRRAELVCLNNT----- 443
+ ++ +L++ + Q+++ + +E L+ V +++ + LN+T
Sbjct: 808 VELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTN 867
Query: 444 ----EISENSSDLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVT 499
++ + D++Q+ + + K E + + + Q Q+K +S HE +++
Sbjct: 868 RELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAE-------HEAKMS 920
Query: 500 EEEINVLKQDLQNA--LEESERNKEKVREL--EEKLVEREKGTVIK------PPVEEYEE 549
++ K NA L + +E++ L E K ++E T+ + P+ +EE
Sbjct: 921 SLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEE 980
Query: 550 MKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLK---DTLKSQMTQEASD---------E 597
+ + + + + + + +KY ++EE+ K K D LK ++ D +
Sbjct: 981 CERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEK 1040
Query: 598 AEDMKEAMNRMIDELNKQVSELSQLY---KEAQAELEDYRKRKSLEDVTAEYIHKAEHEK 654
+ +M+ A++R DELNKQ+ +LSQ Y K + +L + +++ E + + + + +H
Sbjct: 1041 SHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVP 1100
Query: 655 LMQLTNVSRA------KAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSITEHLQVI 708
L Q+ + ++ ++ L M+ Y K +T+L QL++ QK +SV + EHLQ+
Sbjct: 1101 LEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIK 1160
Query: 709 TTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAM----TDAMVPRSSYEKLQ 764
++ + +E +K EV+KL+ ++ K A+ T +V S Y+ +
Sbjct: 1161 EAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDLSKYKATK 1220
Query: 765 SSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEVNELL 824
S LE+++S L KL ++ E+V EV+ + + K EKE + S EQE+ +
Sbjct: 1221 SDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKELLHF---SIEQEIKDQK 1277
Query: 825 QKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTSS-SK 883
++ ++ + E++R + S+K E KD KI E+ +V +LK+ALN LSQL+Y++ + +K
Sbjct: 1278 ERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTYTSGNPTK 1337
Query: 884 RQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQGQMDEDVQKVLKQILTM 943
RQSQ ++ LQ QVK L+ QLA+ +QHQEVI++YR HLL A QG MDEDVQ+ L QI+ M
Sbjct: 1338 RQSQLIDTLQHQVKSLEQQLADADRQHQEVIAIYRTHLLSAAQGHMDEDVQEALLQIIQM 1397
>gi|121582655 ankyrin repeat domain 35 [Homo sapiens]
Length = 1001
Score = 272 bits (696), Expect = 9e-73
Identities = 254/1020 (24%), Positives = 455/1020 (44%), Gaps = 130/1020 (12%)
Query: 16 WNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITH 75
WN++D +LL+AV GD +VA+L +K A TK DS G++ FHLAA+KG ECL +++ +
Sbjct: 17 WNRHDQKLLEAVHRGDVGRVAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLAN 76
Query: 76 GVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAV 135
G D+ +++ G +ALHLA + +C++ LLQ ++VD+ ++ LH+AA+ GC +V
Sbjct: 77 GADINSKNEDGSTALHLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSV 136
Query: 136 QILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEI 195
+LC+H++ +++ D DG PL++A GH+ IC LL GA VN +K+ ++AL+LACE
Sbjct: 137 LLLCDHEAFLDVLDNDGRTPLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEK 196
Query: 196 GSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKIS----------QDA 245
GS+ E L+ GAD VDS G++ALHY+ +++ + L +S Q
Sbjct: 197 GSAEVAELLLSHGADAGAVDSTGHDALHYALHTQDKALWRHLQQALSRRRRGGQRLVQHP 256
Query: 246 DLKTPTKPKQLSDVSSPRSITSTPLSGKESVFFAEPPFKAE------------ISSIREN 293
DL + P + S P+S ++ E P E + +E
Sbjct: 257 DLASQASPSEPQAGSPPKSSWRAEPEEEQEEKEDEDPCSEEWRWKYEEERRKVVRLEQEL 316
Query: 294 KDRLSDSTTGADSLLDISSEADQ--QDLLSLLQAKVASLTLHNKELQ---DKLQAKSPKE 348
+ + T A + LD+ ++ + Q+L LL + + L+ D ++ PK+
Sbjct: 317 VQKTEECKTQAAAYLDLENQIREQAQELGVLLSWEPRASGKQGSSLRPGGDGMEQGCPKD 376
Query: 349 --AEADLSFDSYHSTQTDLGPSL--------------------GKPGETSPPDSKSSPSV 386
AE+ + P L +P E PP S +S ++
Sbjct: 377 LLAESTQELKKQQQAAATVNPVLAPKKAEDSAPGKIQYEVHGRSQPEEQGPPQSPASETI 436
Query: 387 LIHSLGKSTTDNDVRIQQLQEILQDLQKRLESSEAERKQ-LQVELQSRRAELV--CLNNT 443
+ T + Q D +L + + E Q L VE AE V N
Sbjct: 437 ------RKATGQQLTTNGAQTFGPDHADQLPAGQKESSQVLGVEPGGTVAEPVGPAAMNQ 490
Query: 444 EISENSSDLSQKLKETQS---------------------------KYEEAMKEVLSVQKQ 476
+ + +L+ +E + K E ++ VL+ +
Sbjct: 491 LLLQLREELAAVWREKDAARGALSRPVMEGALGTPRAEAAAAAWEKMEARLERVLARLEW 550
Query: 477 MKLGL-VSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESERNKEKVR--ELEEKLVE 533
K GL V PE S L+ I KQD EE E+ R L E
Sbjct: 551 AKAGLQVKPEVPSQESREGALKAAPGSI---KQD-----EEKEKRVPGARGEPLGALGGE 602
Query: 534 REKGTVIKPPVE-EYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMT- 591
+ G + K +E E ++ S +++E + + L + Q Q E+ L L+ +
Sbjct: 603 KALGGLAKGQLEKEMSVLRLSNSNLLEELGE----LGRERQRLQRELQSLSQRLQREFVP 658
Query: 592 -QEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSL--EDVTAEYIH 648
EA + + +++++ + +EL + +L K ++ R D+ E
Sbjct: 659 KPEAQVQLQQLRQSVGLLTNELAMEKEATEKLRKLLASQSSGLRGLWDCLPADLVGERSA 718
Query: 649 KAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSITEHLQ-V 707
+++ + ++ + D E + +++ E QL+ + +E S+
Sbjct: 719 QSKAAESLEELRACISTLVDRHREAQQVLARLQEENQQLRGSLSPCREPGTSLKAPASPQ 778
Query: 708 ITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLE--EKAAMTDAMVPRS--SYEKL 763
+ L ++EE++ ++ ++ K E+ KL++ L + E+ A A S +EK
Sbjct: 779 VAALEQDLGKLEEELRAVQATMSGKSQEIGKLKQLLYQATEEVAELRAREAASLRQHEKT 838
Query: 764 QSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEVNEL 823
+ SL ++ +LK +++ EV ++R V++ +R ++ ++ EQE
Sbjct: 839 RGSLVAQAQAWGQELKALLEKYNTACREVGRLREAVAEERRRSGDLAA--QAAEQE---- 892
Query: 824 LQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTSSSK 883
+QA E +++ +++ L+E + I + K+KE L L QL
Sbjct: 893 ----RQASEMRGRSEQFEKTAELLKEKMEHLIGACRDKEAKIKELLKKLEQL-------- 940
Query: 884 RQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQGQMDEDVQKVLKQILTM 943
S+++ A++ + +L QL + +K H+E+IS YR HLL A +G M+ +V +L QIL+M
Sbjct: 941 --SEEVLAIRGENARLALQLQDSQKNHEEIISTYRNHLLNAARGYMEHEVYNILLQILSM 998
Score = 32.0 bits (71), Expect = 2.8
Identities = 24/53 (45%), Positives = 27/53 (50%), Gaps = 2/53 (3%)
Query: 9 RKSDTNEWNKND-DRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLA 60
R + N +KND L+ A E G AE VA LL GA A DS G A H A
Sbjct: 175 RGARVNVTDKNDKSALILACEKGSAE-VAELLLSHGADAGAVDSTGHDALHYA 226
>gi|126723390 ankyrin repeat domain 24 [Homo sapiens]
Length = 1146
Score = 265 bits (677), Expect = 2e-70
Identities = 260/1025 (25%), Positives = 454/1025 (44%), Gaps = 111/1025 (10%)
Query: 10 KSDTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECL 69
+ + +W K+D+RLLQAVEN DA +VA+L+ +KG TK D EGK+AFHLAA +G CL
Sbjct: 39 RRQSQDWGKSDERLLQAVENNDAPRVAALIARKGLVPTKLDPEGKSAFHLAAMRGAASCL 98
Query: 70 RVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQ 129
VMI HG +V + D G++ALHLAAK H +C+++LLQ+ C + VDSSG TALH+AAA
Sbjct: 99 EVMIAHGSNVMSADGAGYNALHLAAKYGHPQCLKQLLQASCVVDVVDSSGWTALHHAAAG 158
Query: 130 GCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTAL 189
GCL ++LC K+ +N +D G PL++A Q H+++C LL GA N ++ GRTAL
Sbjct: 159 GCLSCSEVLCSFKAHLNPQDRSGATPLIIAAQMCHTDLCRLLLQQGAAANDQDLQGRTAL 218
Query: 190 MLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKT 249
MLACE S VE L++ GA + D+LG +A HY L+ + I LL Q+A +
Sbjct: 219 MLACEGASPETVEVLLQGGAQPGITDALGQDAAHYGALAGDKLILHLL-----QEA-AQR 272
Query: 250 PTKPKQLS-----DVSSPRSITSTPLSGKESVFFAEPPFKA-----------EISSIREN 293
P+ P L+ + SS S++S G A PP + EI +R+
Sbjct: 273 PSPPSALTEDDSGEASSQNSMSSHGKQGAPKKRKAPPPPASIPMPDDRDAYEEIVRLRQE 332
Query: 294 KDRLSDSTTGADSLLD-ISSEADQQDLLSLLQAKVASLTLHNKELQDKLQA--KSPKEAE 350
+ RL G + + E+ + L +L+ +V L E Q++ ++ + + +
Sbjct: 333 RGRLLQKIRGLEQHKERRQQESPEASSLHILERQVQELQQLLVERQEEKESLGREVESLQ 392
Query: 351 ADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDVRIQ------- 403
+ LS T + + E PD + +L L S ++ +Q
Sbjct: 393 SRLSLLENERENTSYDVTTLQDEEGELPDLPGAEVLLSRQLSPSAQEHLASLQEQVAVLT 452
Query: 404 -QLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNN-----TEISENSSDLSQKLK 457
Q QE+++ +Q LE+ E + Q++VE + L ++ ++ ++ Q L+
Sbjct: 453 RQNQELMEKVQ-ILENFEKDETQMEVEALAEVIPLALYDSLRAEFDQLRRQHAEALQALR 511
Query: 458 ETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNALEES 517
+ +++ E +E + + G + ++ + + E ++N + +
Sbjct: 512 QQETR-EVPREEGAACGESEVAGATATKNGPTHMELNGSVAPETKVNG-AETIDEEAAGD 569
Query: 518 ERNKEKVRELEEKLVER-------EKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFE 570
E + + E E E K T KP E EM+++ +E+A +
Sbjct: 570 ETMEARTMEAEATGAEATGAEATGAKVTETKPTGAEVREMETT---------EEEANMET 620
Query: 571 KYQEAQEEIMKLK--DTLKSQMTQEASDEAE-------------------DMKEAMNRMI 609
K AQ + + + + T+ ++EAE +M+ +R
Sbjct: 621 KPTGAQATDTETTGVEAMGVEATKTKAEEAEMQAYGVGAGQAEPPVTGTTNMEATGSRAT 680
Query: 610 DELNKQVSELSQLYKEAQAELEDYRKRKSLEDVTAEYIHKAEHE---KLMQLTNVSRAKA 666
+ VS +A + L AE K + E ++ L R +
Sbjct: 681 GMESTGVSATGVENPGVEATVPGISAGPILHPGAAEASEKLQVELETRIRGLEEALRQRE 740
Query: 667 EDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSIT------EHLQVITTLRTAAKEMEE 720
+A +E+++ K + +L + +E S + Q+ L A +++ +
Sbjct: 741 REAAAELEAALGKCEAAEAEAGRLRERVREAEGSGASGGGGGDTTQLRAALEQAREDLRD 800
Query: 721 KISNLKE-HLASKEVEVAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASKLK 779
+ S L+E AS ++ A+ + L EE+A A + + +L+ S E EV L+
Sbjct: 801 RDSRLRELEAASACLDEARASRLLAEEEARGLRAELAQREEARLEQSRELEV------LR 854
Query: 780 ESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEVNELLQKFQQAQEELAEMKR 839
E + + +E+ + + E L + +E + L + ++A E L +
Sbjct: 855 EQLATARATGEQQRTAAAELGRARDAAEARVAELPAACEEARQGLAELREASEALRQSVV 914
Query: 840 YAESSSKLEEDK----------DKKINEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQL 889
A +L+E+ ++++ KE +L+ L S + S +R +
Sbjct: 915 PASEHRRLQEEALELRGRAASLEQEVVATGKEAARLRAELERERVCSVALSEHER---IV 971
Query: 890 EALQQQVKQLQNQLAECKKQHQ----EVISVYRMHLLYAVQGQMDEDVQKVLKQILTMCK 945
LQ V QL+ QL E ++H+ EV V R L + E +Q L +
Sbjct: 972 GTLQANVAQLEGQLEELGRRHEKTSAEVFQVQREALFMKSERHAAEAQLATAEQQLRGLR 1031
Query: 946 NQSQK 950
++++
Sbjct: 1032 TEAER 1036
Score = 157 bits (397), Expect = 4e-38
Identities = 131/454 (28%), Positives = 222/454 (48%), Gaps = 39/454 (8%)
Query: 502 EINVLKQDLQNALEESERNKEKVRELEEKL-----VEREKGTVIKPPVEEYEEMKSSYCS 556
E+ + L+ AL + ER E ELE L E E G ++ V E E +S
Sbjct: 724 ELETRIRGLEEALRQRER--EAAAELEAALGKCEAAEAEAGR-LRERVREAEGSGASGGG 780
Query: 557 VIENMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEAS-DEAEDMKEAMNRMIDELNKQ 615
+ A ++A+E++ L+ A DEA + L +
Sbjct: 781 GGDTTQLRAAL-----EQAREDLRDRDSRLRELEAASACLDEARASRLLAEEEARGLRAE 835
Query: 616 VSELSQLYKEAQAELEDYRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKS 675
+++ + E ELE R++ + T E A E +R AE ++E+ +
Sbjct: 836 LAQREEARLEQSRELEVLREQLATARATGEQQRTAAAE-----LGRARDAAEARVAELPA 890
Query: 676 QYSKVLNELTQLKQLVDAQKENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVE 735
+ L +L++ +A +++ V +EH + L+ A E+ + ++L++ + + E
Sbjct: 891 ACEEARQGLAELREASEALRQSVVPASEHRR----LQEEALELRGRAASLEQEVVATGKE 946
Query: 736 VAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQI 795
A+L +L E+ V S +E++ +L++ V+ L +L+E + EK +EV Q+
Sbjct: 947 AARLRAELERERVCS----VALSEHERIVGTLQANVAQLEGQLEELGRRHEKTSAEVFQV 1002
Query: 796 RSEVSQVKREKENIQTLLKSKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKI 855
+ E +K E+ + L + EQ++ L + ++A++ R E+ K +E KDKKI
Sbjct: 1003 QREALFMKSERHAAEAQLATAEQQLRGLRTEAERARQA---QSRAQEALDKAKE-KDKKI 1058
Query: 856 NEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVIS 915
E+SKEV LKEAL + + ++EAL+ QVK LQ QL E + H V++
Sbjct: 1059 TELSKEVFNLKEALKE--------QPAALATPEVEALRDQVKDLQQQLQEAARDHSSVVA 1110
Query: 916 VYRMHLLYAVQGQMDEDVQKVLKQILTMCKNQSQ 949
+YR HLLYA+QGQMDEDVQ++L QIL M + Q+Q
Sbjct: 1111 LYRSHLLYAIQGQMDEDVQRILSQILQMQRLQAQ 1144
Score = 30.8 bits (68), Expect = 6.3
Identities = 33/133 (24%), Positives = 64/133 (48%), Gaps = 12/133 (9%)
Query: 402 IQQLQEILQDLQKRLESSEAERKQLQVE---LQSRR--AELVCLNNTEISENSSDLSQKL 456
+ QL+ L++L +R E + AE Q+Q E ++S R AE + +++
Sbjct: 978 VAQLEGQLEELGRRHEKTSAEVFQVQREALFMKSERHAAEAQLATAEQQLRGLRTEAERA 1037
Query: 457 KETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHE--LRVTEEEINVLK---QDLQ 511
++ QS+ +EA+ + + +K K+ +S E + E + E+ L+ +DLQ
Sbjct: 1038 RQAQSRAQEALDK--AKEKDKKITELSKEVFNLKEALKEQPAALATPEVEALRDQVKDLQ 1095
Query: 512 NALEESERNKEKV 524
L+E+ R+ V
Sbjct: 1096 QQLQEAARDHSSV 1108
>gi|239756999 PREDICTED: ankyrin repeat domain 62 [Homo sapiens]
Length = 917
Score = 125 bits (315), Expect = 1e-28
Identities = 188/897 (20%), Positives = 370/897 (41%), Gaps = 103/897 (11%)
Query: 30 GDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSA 89
GD KV + + D + +TA LA A G + ++ + D+ +A
Sbjct: 49 GDVNKVMESILLRLNDLNDRDKKNRTALLLACAHGRPGVVADLVARKCQLNLTDSENRTA 108
Query: 90 LHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKD 149
L A + C LL+ D G TALHYA + + L + + I +
Sbjct: 109 LIKAVQCQEEVCASILLEHGANPNVRDMYGNTALHYAIDNENISMARKLLAYGADIEARS 168
Query: 150 LDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGA 209
DG+ LLLAV ++ FLL D+ + + GRTAL+LA GS++ V L++
Sbjct: 169 QDGHTSLLLAVNRKKEQMVSFLLKKKPDLTAIDNFGRTALILAARNGSTSVVYQLLQHNI 228
Query: 210 DLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKTPTKPKQLSDVSSPRSITSTP 269
D+ D G+ A Y+ S+ I+ ++ ++ K + K L + +S + + T
Sbjct: 229 DVFCQDISGWTAEDYAVASKFQAIRGMI-------SEYKANKRRKSLQNSNSEQDLEMTS 281
Query: 270 ------LSGKESVFFAEPPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLL 323
L G ES ++P + ++ R K +S + DS + D +L+ +
Sbjct: 282 EGEQERLEGCES---SQPQVEEKMKKCRNKKMEVSRNVHADDS---DNYNDDVDELIHKI 335
Query: 324 QAKV----ASLTLHNKELQDKLQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETS--P 377
+ + S N E D+L K+ E S + D+ S K E P
Sbjct: 336 KNRKPDNHQSPGKENGEF-DRLARKTSNEKSKVKSQIYFTDDLNDISGSSEKTSEDDELP 394
Query: 378 PDSKSSPSVLIHSLGKSTTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAEL 437
+ +LI G D V + + + + +E + ++L+V+ Q + +
Sbjct: 395 YSDDENFMLLIKQSGMECKD-FVSLSKSKNATAACGRSIEDQKCYCERLKVKFQKMKNNI 453
Query: 438 VCLNNTEISENSSDLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELR 497
L +SE SQ + ++ +Q+Q + + + E + EL+
Sbjct: 454 SVLQKV-LSETDKTKSQSEHQNLQGKKKLCNLRFILQQQEEERIKAEELYE--KDIEELK 510
Query: 498 VTEEE--------------INVLKQDLQNALEESERN---KEKVREL-EEKLVEREKGTV 539
+ EE+ + L+ +L+ S +N E+ R+L +E + R++
Sbjct: 511 IMEEQYRTQTEVKKQSKLTLKSLEVELKTVRSNSNQNFHTHERERDLWQENHLMRDEIAR 570
Query: 540 IKPPVE----EYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEAS 595
++ ++ + +E ++ Y IE + E ++ ++ + + ++TL +T+ +
Sbjct: 571 LRLEIDTIKHQNQETENKYFKDIE-------IIKENNEDLEKTLKRNEETLTKTITRYSK 623
Query: 596 DEAEDMKEAMNRMIDE---LNKQVSELSQLYKEAQAELEDYRKRKSLEDVTAEYIHKAEH 652
+ +N ++DE LN ++ + Q + E+E YR R L ++ +
Sbjct: 624 E--------LNVLMDENTMLNSELQKEKQSMSRLETEMESYRCR--LAAALCDHDQRQSS 673
Query: 653 EKLMQLTNVSRAKAEDALSEMKSQYSKVLNEL------------TQLKQLVDAQKENSVS 700
++ +QL S L E + + ++L++ T+L +A KE ++
Sbjct: 674 KRDLQLAFQSTVNEWCHLQEDTNSHIQILSQQLSKAESTSSGLETELHYEREALKEKTLH 733
Query: 701 ITEHLQ-VITTLRTAAKEMEEKISN---LKEHLASKEVEVA----KLEKQLLEEKAAMTD 752
I EH+Q V++ + +++E N + E K+ V +L+ Q L + D
Sbjct: 734 I-EHMQGVLSRTQRRLEDIEHMYQNDQPILEKYVRKQQSVEDGLFQLQSQNLLYQQQCND 792
Query: 753 AMVPRSSYEK----LQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKEN 808
A + EK +Q E V L ++ ++ + + + E ++ Q ++EKE
Sbjct: 793 ARKKADNQEKTIINIQVKCEDTVEKLQAECRKLEENNKGLMKECTLLKERQCQYEKEKEE 852
Query: 809 IQTLLKSKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKD---KKINEMSKEV 862
+ + + ++EV++ L K Q E + E+ +E LE++ KK+ +M +V
Sbjct: 853 REVVRRQLQREVDDALNK-QLLLEAMLEIS--SERRINLEDEAQSLKKKLGQMRSQV 906
Score = 98.2 bits (243), Expect = 3e-20
Identities = 174/822 (21%), Positives = 339/822 (41%), Gaps = 85/822 (10%)
Query: 17 NKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHG 76
++N L++AV+ + E AS+L + GA+ D G TA H A ++ R ++ +G
Sbjct: 103 SENRTALIKAVQCQE-EVCASILLEHGANPNVRDMYGNTALHYAIDNENISMARKLLAYG 161
Query: 77 VDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQ 136
D+ A+ GH++L LA + + LL+ K ++D+ G+TAL AA G V
Sbjct: 162 ADIEARSQDGHTSLLLAVNRKKEQMVSFLLKKKPDLTAIDNFGRTALILAARNGSTSVVY 221
Query: 137 ILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKS------------ 184
L +H + +D+ G AV + I + ++ A N R KS
Sbjct: 222 QLLQHNIDVFCQDISGWTAEDYAVASKFQAIRGMISEYKA--NKRRKSLQNSNSEQDLEM 279
Query: 185 ---GRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKI 241
G + CE S VE +KK + + S +A +++ L+ KI
Sbjct: 280 TSEGEQERLEGCE-SSQPQVEEKMKKCRNKKMEVSRNVHADDSDNYNDDV---DELIHKI 335
Query: 242 SQDADLKTPTKPKQLSDVSSPRSITSTPLSG-KESVFFAEPPFKAEISSIRENK-DRLSD 299
+ K+ + TS S K ++F + SS + ++ D L
Sbjct: 336 KNRKPDNHQSPGKENGEFDRLARKTSNEKSKVKSQIYFTDDLNDISGSSEKTSEDDELPY 395
Query: 300 STTGADSLLDISSEADQQDLLSLLQAKVASLTLHNKELQD------KLQAKSPKEAEADL 353
S LL S + +D +SL ++K A+ + ++D +L+ K K + ++
Sbjct: 396 SDDENFMLLIKQSGMECKDFVSLSKSKNATAAC-GRSIEDQKCYCERLKVKFQK-MKNNI 453
Query: 354 SFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDVRIQQLQEILQDLQ 413
S ++TD S + + ++ + + ++ E L+ ++
Sbjct: 454 SVLQKVLSETDKTKSQSEHQNLQGKKKLCNLRFILQQQEEERIKAEELYEKDIEELKIME 513
Query: 414 KRLESSEAERKQLQVELQSRRAELVCL-----NNTEISENSSDLSQ-------------- 454
++ + +KQ ++ L+S EL + N E DL Q
Sbjct: 514 EQYRTQTEVKKQSKLTLKSLEVELKTVRSNSNQNFHTHERERDLWQENHLMRDEIARLRL 573
Query: 455 -------KLKETQSKYEEAMKEVLSVQKQMKLGLVSPE-----SMDNYSHFHELRVTEEE 502
+ +ET++KY + ++ + + ++ L E ++ YS EL V +E
Sbjct: 574 EIDTIKHQNQETENKYFKDIEIIKENNEDLEKTLKRNEETLTKTITRYS--KELNVLMDE 631
Query: 503 INVLKQDLQNALEESERNKEKVR----ELEEKLVEREKGTVIKPPVE-EYEEMKSSYCSV 557
+L +LQ + R + ++ L L + ++ K ++ ++ + +C +
Sbjct: 632 NTMLNSELQKEKQSMSRLETEMESYRCRLAAALCDHDQRQSSKRDLQLAFQSTVNEWCHL 691
Query: 558 IENMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVS 617
E+ N L ++ +A+ L+ L + +EA E E M ++ +++
Sbjct: 692 QEDTNSHIQILSQQLSKAESTSSGLETELHYE--REALKEKTLHIEHMQGVLSRTQRRLE 749
Query: 618 ELSQLYKEAQAELEDY-RKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQ 676
++ +Y+ Q LE Y RK++S+ED + ++++ Q N +R KA++ + +
Sbjct: 750 DIEHMYQNDQPILEKYVRKQQSVEDGLFQL--QSQNLLYQQQCNDARKKADNQEKTIINI 807
Query: 677 YSKVLNELTQLKQLVDAQKENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEV 736
K + + +L+ +EN+ + + ++ R E E++ + +EV+
Sbjct: 808 QVKCEDTVEKLQAECRKLEENNKGLMKECTLLKE-RQCQYEKEKEEREVVRRQLQREVDD 866
Query: 737 AKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASKL 778
A L KQLL E AM+ SS ++ +LE E L KL
Sbjct: 867 A-LNKQLLLE------AMLEISSERRI--NLEDEAQSLKKKL 899
Score = 50.8 bits (120), Expect = 6e-06
Identities = 79/404 (19%), Positives = 181/404 (44%), Gaps = 42/404 (10%)
Query: 536 KGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEAS 595
K I+ + EY+ K ++N N E+ E E ++E +L+ SQ E
Sbjct: 248 KFQAIRGMISEYKANKRR--KSLQNSNSEQDL--EMTSEGEQE--RLEGCESSQPQVE-- 299
Query: 596 DEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLEDVTAEYIHKAEHEKL 655
E MK+ N+ ++ ++ S Y + EL K + ++ + E ++L
Sbjct: 300 ---EKMKKCRNKKMEVSRNVHADDSDNYNDDVDELIHKIKNRKPDNHQSPGKENGEFDRL 356
Query: 656 MQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSITEHLQVITTLRTAA 715
+ T+ ++K + + ++ LN+++ + E S E+ ++ ++ +
Sbjct: 357 ARKTSNEKSKVKSQI-----YFTDDLNDISGSSEKTSEDDELPYSDDENFMLL--IKQSG 409
Query: 716 KEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLESEVSVLA 775
E ++ +S L+ + A + + ++K V ++K++++ +SVL
Sbjct: 410 MECKDFVS-----LSKSKNATAACGRSIEDQKCYCERLKV---KFQKMKNN----ISVLQ 457
Query: 776 SKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEVNELLQKFQQAQEELA 835
L E+ K K Q + Q K++ N++ +L+ +E+E + + +++ EEL
Sbjct: 458 KVLSETDKTKS-------QSEHQNLQGKKKLCNLRFILQQQEEERIKAEELYEKDIEELK 510
Query: 836 EMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQLEALQQQ 895
M+ + ++ E K K+ S EV +LK ++ +Q ++ + Q+ ++ +
Sbjct: 511 IMEE--QYRTQTEVKKQSKLTLKSLEV-ELKTVRSNSNQNFHTHERERDLWQENHLMRDE 567
Query: 896 VKQLQNQLAECKKQHQEVISVYRMHLLYAVQGQMDEDVQKVLKQ 939
+ +L+ ++ K Q+QE + Y + + + +ED++K LK+
Sbjct: 568 IARLRLEIDTIKHQNQETENKYFKDI--EIIKENNEDLEKTLKR 609
>gi|239751514 PREDICTED: ankyrin repeat domain 62 isoform 4 [Homo
sapiens]
Length = 917
Score = 125 bits (315), Expect = 1e-28
Identities = 188/897 (20%), Positives = 370/897 (41%), Gaps = 103/897 (11%)
Query: 30 GDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSA 89
GD KV + + D + +TA LA A G + ++ + D+ +A
Sbjct: 49 GDVNKVMESILLRLNDLNDRDKKNRTALLLACAHGRPGVVADLVARKCQLNLTDSENRTA 108
Query: 90 LHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKD 149
L A + C LL+ D G TALHYA + + L + + I +
Sbjct: 109 LIKAVQCQEEVCASILLEHGANPNVRDMYGNTALHYAIDNENISMARKLLAYGADIEARS 168
Query: 150 LDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGA 209
DG+ LLLAV ++ FLL D+ + + GRTAL+LA GS++ V L++
Sbjct: 169 QDGHTSLLLAVNRKKEQMVSFLLKKKPDLTAIDNFGRTALILAARNGSTSVVYQLLQHNI 228
Query: 210 DLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKTPTKPKQLSDVSSPRSITSTP 269
D+ D G+ A Y+ S+ I+ ++ ++ K + K L + +S + + T
Sbjct: 229 DVFCQDISGWTAEDYAVASKFQAIRGMI-------SEYKANKRRKSLQNSNSEQDLEMTS 281
Query: 270 ------LSGKESVFFAEPPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLL 323
L G ES ++P + ++ R K +S + DS + D +L+ +
Sbjct: 282 EGEQERLEGCES---SQPQVEEKMKKCRNKKMEVSRNVHADDS---DNYNDDVDELIHKI 335
Query: 324 QAKV----ASLTLHNKELQDKLQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETS--P 377
+ + S N E D+L K+ E S + D+ S K E P
Sbjct: 336 KNRKPDNHQSPGKENGEF-DRLARKTSNEKSKVKSQIYFTDDLNDISGSSEKTSEDDELP 394
Query: 378 PDSKSSPSVLIHSLGKSTTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAEL 437
+ +LI G D V + + + + +E + ++L+V+ Q + +
Sbjct: 395 YSDDENFMLLIKQSGMECKD-FVSLSKSKNATAACGRSIEDQKCYCERLKVKFQKMKNNI 453
Query: 438 VCLNNTEISENSSDLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELR 497
L +SE SQ + ++ +Q+Q + + + E + EL+
Sbjct: 454 SVLQKV-LSETDKTKSQSEHQNLQGKKKLCNLRFILQQQEEERIKAEELYE--KDIEELK 510
Query: 498 VTEEE--------------INVLKQDLQNALEESERN---KEKVREL-EEKLVEREKGTV 539
+ EE+ + L+ +L+ S +N E+ R+L +E + R++
Sbjct: 511 IMEEQYRTQTEVKKQSKLTLKSLEVELKTVRSNSNQNFHTHERERDLWQENHLMRDEIAR 570
Query: 540 IKPPVE----EYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEAS 595
++ ++ + +E ++ Y IE + E ++ ++ + + ++TL +T+ +
Sbjct: 571 LRLEIDTIKHQNQETENKYFKDIE-------IIKENNEDLEKTLKRNEETLTKTITRYSK 623
Query: 596 DEAEDMKEAMNRMIDE---LNKQVSELSQLYKEAQAELEDYRKRKSLEDVTAEYIHKAEH 652
+ +N ++DE LN ++ + Q + E+E YR R L ++ +
Sbjct: 624 E--------LNVLMDENTMLNSELQKEKQSMSRLETEMESYRCR--LAAALCDHDQRQSS 673
Query: 653 EKLMQLTNVSRAKAEDALSEMKSQYSKVLNEL------------TQLKQLVDAQKENSVS 700
++ +QL S L E + + ++L++ T+L +A KE ++
Sbjct: 674 KRDLQLAFQSTVNEWCHLQEDTNSHIQILSQQLSKAESTSSGLETELHYEREALKEKTLH 733
Query: 701 ITEHLQ-VITTLRTAAKEMEEKISN---LKEHLASKEVEVA----KLEKQLLEEKAAMTD 752
I EH+Q V++ + +++E N + E K+ V +L+ Q L + D
Sbjct: 734 I-EHMQGVLSRTQRRLEDIEHMYQNDQPILEKYVRKQQSVEDGLFQLQSQNLLYQQQCND 792
Query: 753 AMVPRSSYEK----LQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKEN 808
A + EK +Q E V L ++ ++ + + + E ++ Q ++EKE
Sbjct: 793 ARKKADNQEKTIINIQVKCEDTVEKLQAECRKLEENNKGLMKECTLLKERQCQYEKEKEE 852
Query: 809 IQTLLKSKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKD---KKINEMSKEV 862
+ + + ++EV++ L K Q E + E+ +E LE++ KK+ +M +V
Sbjct: 853 REVVRRQLQREVDDALNK-QLLLEAMLEIS--SERRINLEDEAQSLKKKLGQMRSQV 906
Score = 98.2 bits (243), Expect = 3e-20
Identities = 174/822 (21%), Positives = 339/822 (41%), Gaps = 85/822 (10%)
Query: 17 NKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHG 76
++N L++AV+ + E AS+L + GA+ D G TA H A ++ R ++ +G
Sbjct: 103 SENRTALIKAVQCQE-EVCASILLEHGANPNVRDMYGNTALHYAIDNENISMARKLLAYG 161
Query: 77 VDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQ 136
D+ A+ GH++L LA + + LL+ K ++D+ G+TAL AA G V
Sbjct: 162 ADIEARSQDGHTSLLLAVNRKKEQMVSFLLKKKPDLTAIDNFGRTALILAARNGSTSVVY 221
Query: 137 ILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKS------------ 184
L +H + +D+ G AV + I + ++ A N R KS
Sbjct: 222 QLLQHNIDVFCQDISGWTAEDYAVASKFQAIRGMISEYKA--NKRRKSLQNSNSEQDLEM 279
Query: 185 ---GRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKI 241
G + CE S VE +KK + + S +A +++ L+ KI
Sbjct: 280 TSEGEQERLEGCE-SSQPQVEEKMKKCRNKKMEVSRNVHADDSDNYNDDV---DELIHKI 335
Query: 242 SQDADLKTPTKPKQLSDVSSPRSITSTPLSG-KESVFFAEPPFKAEISSIRENK-DRLSD 299
+ K+ + TS S K ++F + SS + ++ D L
Sbjct: 336 KNRKPDNHQSPGKENGEFDRLARKTSNEKSKVKSQIYFTDDLNDISGSSEKTSEDDELPY 395
Query: 300 STTGADSLLDISSEADQQDLLSLLQAKVASLTLHNKELQD------KLQAKSPKEAEADL 353
S LL S + +D +SL ++K A+ + ++D +L+ K K + ++
Sbjct: 396 SDDENFMLLIKQSGMECKDFVSLSKSKNATAAC-GRSIEDQKCYCERLKVKFQK-MKNNI 453
Query: 354 SFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDVRIQQLQEILQDLQ 413
S ++TD S + + ++ + + ++ E L+ ++
Sbjct: 454 SVLQKVLSETDKTKSQSEHQNLQGKKKLCNLRFILQQQEEERIKAEELYEKDIEELKIME 513
Query: 414 KRLESSEAERKQLQVELQSRRAELVCL-----NNTEISENSSDLSQ-------------- 454
++ + +KQ ++ L+S EL + N E DL Q
Sbjct: 514 EQYRTQTEVKKQSKLTLKSLEVELKTVRSNSNQNFHTHERERDLWQENHLMRDEIARLRL 573
Query: 455 -------KLKETQSKYEEAMKEVLSVQKQMKLGLVSPE-----SMDNYSHFHELRVTEEE 502
+ +ET++KY + ++ + + ++ L E ++ YS EL V +E
Sbjct: 574 EIDTIKHQNQETENKYFKDIEIIKENNEDLEKTLKRNEETLTKTITRYS--KELNVLMDE 631
Query: 503 INVLKQDLQNALEESERNKEKVR----ELEEKLVEREKGTVIKPPVE-EYEEMKSSYCSV 557
+L +LQ + R + ++ L L + ++ K ++ ++ + +C +
Sbjct: 632 NTMLNSELQKEKQSMSRLETEMESYRCRLAAALCDHDQRQSSKRDLQLAFQSTVNEWCHL 691
Query: 558 IENMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVS 617
E+ N L ++ +A+ L+ L + +EA E E M ++ +++
Sbjct: 692 QEDTNSHIQILSQQLSKAESTSSGLETELHYE--REALKEKTLHIEHMQGVLSRTQRRLE 749
Query: 618 ELSQLYKEAQAELEDY-RKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQ 676
++ +Y+ Q LE Y RK++S+ED + ++++ Q N +R KA++ + +
Sbjct: 750 DIEHMYQNDQPILEKYVRKQQSVEDGLFQL--QSQNLLYQQQCNDARKKADNQEKTIINI 807
Query: 677 YSKVLNELTQLKQLVDAQKENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEV 736
K + + +L+ +EN+ + + ++ R E E++ + +EV+
Sbjct: 808 QVKCEDTVEKLQAECRKLEENNKGLMKECTLLKE-RQCQYEKEKEEREVVRRQLQREVDD 866
Query: 737 AKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASKL 778
A L KQLL E AM+ SS ++ +LE E L KL
Sbjct: 867 A-LNKQLLLE------AMLEISSERRI--NLEDEAQSLKKKL 899
Score = 50.8 bits (120), Expect = 6e-06
Identities = 79/404 (19%), Positives = 181/404 (44%), Gaps = 42/404 (10%)
Query: 536 KGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEAS 595
K I+ + EY+ K ++N N E+ E E ++E +L+ SQ E
Sbjct: 248 KFQAIRGMISEYKANKRR--KSLQNSNSEQDL--EMTSEGEQE--RLEGCESSQPQVE-- 299
Query: 596 DEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLEDVTAEYIHKAEHEKL 655
E MK+ N+ ++ ++ S Y + EL K + ++ + E ++L
Sbjct: 300 ---EKMKKCRNKKMEVSRNVHADDSDNYNDDVDELIHKIKNRKPDNHQSPGKENGEFDRL 356
Query: 656 MQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSITEHLQVITTLRTAA 715
+ T+ ++K + + ++ LN+++ + E S E+ ++ ++ +
Sbjct: 357 ARKTSNEKSKVKSQI-----YFTDDLNDISGSSEKTSEDDELPYSDDENFMLL--IKQSG 409
Query: 716 KEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLESEVSVLA 775
E ++ +S L+ + A + + ++K V ++K++++ +SVL
Sbjct: 410 MECKDFVS-----LSKSKNATAACGRSIEDQKCYCERLKV---KFQKMKNN----ISVLQ 457
Query: 776 SKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEVNELLQKFQQAQEELA 835
L E+ K K Q + Q K++ N++ +L+ +E+E + + +++ EEL
Sbjct: 458 KVLSETDKTKS-------QSEHQNLQGKKKLCNLRFILQQQEEERIKAEELYEKDIEELK 510
Query: 836 EMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQLEALQQQ 895
M+ + ++ E K K+ S EV +LK ++ +Q ++ + Q+ ++ +
Sbjct: 511 IMEE--QYRTQTEVKKQSKLTLKSLEV-ELKTVRSNSNQNFHTHERERDLWQENHLMRDE 567
Query: 896 VKQLQNQLAECKKQHQEVISVYRMHLLYAVQGQMDEDVQKVLKQ 939
+ +L+ ++ K Q+QE + Y + + + +ED++K LK+
Sbjct: 568 IARLRLEIDTIKHQNQETENKYFKDI--EIIKENNEDLEKTLKR 609
>gi|239746016 PREDICTED: ankyrin repeat domain 62 isoform 1 [Homo
sapiens]
Length = 917
Score = 124 bits (312), Expect = 3e-28
Identities = 189/892 (21%), Positives = 363/892 (40%), Gaps = 93/892 (10%)
Query: 30 GDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSA 89
GD KV + + D + +TA LA A G + ++ + D+ +A
Sbjct: 49 GDVNKVMESILLRLNDLNDRDKKNRTALLLACAHGRPGVVADLVARKCQLNLTDSENRTA 108
Query: 90 LHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKD 149
L A + C LL+ D G TALHYA + + L + + I +
Sbjct: 109 LIKAVQCQEEVCASILLEHGANPNVRDMYGNTALHYAIDNENISMARKLLAYGADIEARS 168
Query: 150 LDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGA 209
DG+ LLLAV ++ FLL D+ + + GRTAL+LA GS++ V L++
Sbjct: 169 QDGHTSLLLAVNRKKEQMVAFLLKKKPDLTAIDNFGRTALILAARNGSTSVVYQLLQHNI 228
Query: 210 DLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKTPTKPKQLSDVSSPRSITSTP 269
D+ D G+ A Y+ S+ I+ ++ ++ K + K L + +S + + T
Sbjct: 229 DVFCQDISGWTAEDYAVASKFQAIRGMI-------SEYKANKRCKSLQNSNSEQDLEMTS 281
Query: 270 ------LSGKESVFFAEPPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLL 323
L G ES ++P + ++ R K +S + DS + D +L+ +
Sbjct: 282 EGEQERLEGCES---SQPQVEEKMKKCRNKKMEVSRNVHADDS---DNYNDDVDELIHKI 335
Query: 324 QAKV----ASLTLHNKELQDKLQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETS--P 377
+ + S N E D+L K+ E S + D+ S K E P
Sbjct: 336 KNRKPDNHQSPGKENGEF-DRLARKTSNEKSKVKSQIYFTDDLNDISGSSEKTSEDDELP 394
Query: 378 PDSKSSPSVLIHSLGKSTTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAEL 437
+ +LI G D V + + + + +E + ++L+V+ Q
Sbjct: 395 YSDDENFMLLIEQSGMECKD-FVSLSKSKNATAACGRSIEDQKCYCERLKVKFQ------ 447
Query: 438 VCLNNTEISENSSDLSQKLKETQSKYEEAMKEVLSVQKQM-KLGLVSPESMDNYSHFHEL 496
++ N S L + L ET ++ + L +K++ L + + + EL
Sbjct: 448 ------KMKNNISVLQKVLSETDKTKSQSEHQNLQGKKKLCNLRFILQQQEEERIKAEEL 501
Query: 497 RVTE-EEINVLKQDLQNALEESERNKEKVRELEEKLV-------------EREKGTVIKP 542
+ EE+ ++++ + E +++K ++ LE +L ERE+ +
Sbjct: 502 YEKDIEELKIMEEQYRTQTEVKKQSKLTLKSLEVELKTVRSNSNQNFHTHERERDLWQEN 561
Query: 543 PV--EEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEASDEAED 600
+ +E ++ ++ + + F+ + +E L+ TLK
Sbjct: 562 HLMRDEIARLRLEIDTIKHQNQETENKYFKDIEIIKENNEDLEKTLKRNEEALTKTITRY 621
Query: 601 MKEAMNRMIDE---LNKQVSELSQLYKEAQAELEDYRKRKSLEDVTAEYIHKAEHEKLMQ 657
KE +N ++DE LN ++ + Q + E+E YR R L ++ + ++ +Q
Sbjct: 622 SKE-LNVLMDENTMLNSELQKEKQSMSRLETEMESYRCR--LAAALCDHDQRQSSKRDLQ 678
Query: 658 LTNVSRAKAEDALSEMKSQYSKVLNEL------------TQLKQLVDAQKENSVSITEHL 705
L S L E + + ++L++ T+L +A KE ++ I EH+
Sbjct: 679 LAFQSTVNEWCHLQEDTNSHIQILSQQLSKAESTSSGLETELHYEREALKEKTLHI-EHM 737
Query: 706 Q-VITTLRTAAKEMEEKISN---LKEHLASKEVEVA----KLEKQLLEEKAAMTDAMVPR 757
Q V++ + +++E N + E K+ V +L+ Q L + DA
Sbjct: 738 QGVLSRTQRRLEDIEHMYQNDQPILEKYVRKQQSVEDGLFQLQSQNLLYQQQCNDARKKA 797
Query: 758 SSYEK----LQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLL 813
+ EK +Q E V L ++ ++ + + + E ++ Q ++EKE + +
Sbjct: 798 DNQEKTIINIQVKCEDTVEKLQAECRKLEENNKGLMKECTLLKERQCQYEKEKEEREVVR 857
Query: 814 KSKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKD---KKINEMSKEV 862
+ ++EV++ L K Q E + E+ +E LE++ KK+ +M +V
Sbjct: 858 RQLQREVDDALNK-QLLLEAMLEIS--SERRINLEDEAQSLKKKLGQMRSQV 906
Score = 97.1 bits (240), Expect = 7e-20
Identities = 174/822 (21%), Positives = 339/822 (41%), Gaps = 85/822 (10%)
Query: 17 NKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHG 76
++N L++AV+ + E AS+L + GA+ D G TA H A ++ R ++ +G
Sbjct: 103 SENRTALIKAVQCQE-EVCASILLEHGANPNVRDMYGNTALHYAIDNENISMARKLLAYG 161
Query: 77 VDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQ 136
D+ A+ GH++L LA + + LL+ K ++D+ G+TAL AA G V
Sbjct: 162 ADIEARSQDGHTSLLLAVNRKKEQMVAFLLKKKPDLTAIDNFGRTALILAARNGSTSVVY 221
Query: 137 ILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKS------------ 184
L +H + +D+ G AV + I + ++ A N R KS
Sbjct: 222 QLLQHNIDVFCQDISGWTAEDYAVASKFQAIRGMISEYKA--NKRCKSLQNSNSEQDLEM 279
Query: 185 ---GRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKI 241
G + CE S VE +KK + + S +A +++ L+ KI
Sbjct: 280 TSEGEQERLEGCE-SSQPQVEEKMKKCRNKKMEVSRNVHADDSDNYNDDV---DELIHKI 335
Query: 242 SQDADLKTPTKPKQLSDVSSPRSITSTPLSG-KESVFFAEPPFKAEISSIRENK-DRLSD 299
+ K+ + TS S K ++F + SS + ++ D L
Sbjct: 336 KNRKPDNHQSPGKENGEFDRLARKTSNEKSKVKSQIYFTDDLNDISGSSEKTSEDDELPY 395
Query: 300 STTGADSLLDISSEADQQDLLSLLQAKVASLTLHNKELQD------KLQAKSPKEAEADL 353
S LL S + +D +SL ++K A+ + ++D +L+ K K + ++
Sbjct: 396 SDDENFMLLIEQSGMECKDFVSLSKSKNATAAC-GRSIEDQKCYCERLKVKFQK-MKNNI 453
Query: 354 SFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDVRIQQLQEILQDLQ 413
S ++TD S + + ++ + + ++ E L+ ++
Sbjct: 454 SVLQKVLSETDKTKSQSEHQNLQGKKKLCNLRFILQQQEEERIKAEELYEKDIEELKIME 513
Query: 414 KRLESSEAERKQLQVELQSRRAELVCL-----NNTEISENSSDLSQ-------------- 454
++ + +KQ ++ L+S EL + N E DL Q
Sbjct: 514 EQYRTQTEVKKQSKLTLKSLEVELKTVRSNSNQNFHTHERERDLWQENHLMRDEIARLRL 573
Query: 455 -------KLKETQSKYEEAMKEVLSVQKQMKLGLVSPE-----SMDNYSHFHELRVTEEE 502
+ +ET++KY + ++ + + ++ L E ++ YS EL V +E
Sbjct: 574 EIDTIKHQNQETENKYFKDIEIIKENNEDLEKTLKRNEEALTKTITRYS--KELNVLMDE 631
Query: 503 INVLKQDLQNALEESERNKEKVR----ELEEKLVEREKGTVIKPPVE-EYEEMKSSYCSV 557
+L +LQ + R + ++ L L + ++ K ++ ++ + +C +
Sbjct: 632 NTMLNSELQKEKQSMSRLETEMESYRCRLAAALCDHDQRQSSKRDLQLAFQSTVNEWCHL 691
Query: 558 IENMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVS 617
E+ N L ++ +A+ L+ L + +EA E E M ++ +++
Sbjct: 692 QEDTNSHIQILSQQLSKAESTSSGLETELHYE--REALKEKTLHIEHMQGVLSRTQRRLE 749
Query: 618 ELSQLYKEAQAELEDY-RKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQ 676
++ +Y+ Q LE Y RK++S+ED + ++++ Q N +R KA++ + +
Sbjct: 750 DIEHMYQNDQPILEKYVRKQQSVEDGLFQL--QSQNLLYQQQCNDARKKADNQEKTIINI 807
Query: 677 YSKVLNELTQLKQLVDAQKENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEV 736
K + + +L+ +EN+ + + ++ R E E++ + +EV+
Sbjct: 808 QVKCEDTVEKLQAECRKLEENNKGLMKECTLLKE-RQCQYEKEKEEREVVRRQLQREVDD 866
Query: 737 AKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASKL 778
A L KQLL E AM+ SS ++ +LE E L KL
Sbjct: 867 A-LNKQLLLE------AMLEISSERRI--NLEDEAQSLKKKL 899
Score = 53.9 bits (128), Expect = 7e-07
Identities = 80/404 (19%), Positives = 181/404 (44%), Gaps = 42/404 (10%)
Query: 536 KGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEAS 595
K I+ + EY+ K C ++N N E+ E E ++E +L+ SQ E
Sbjct: 248 KFQAIRGMISEYKANKR--CKSLQNSNSEQDL--EMTSEGEQE--RLEGCESSQPQVE-- 299
Query: 596 DEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLEDVTAEYIHKAEHEKL 655
E MK+ N+ ++ ++ S Y + EL K + ++ + E ++L
Sbjct: 300 ---EKMKKCRNKKMEVSRNVHADDSDNYNDDVDELIHKIKNRKPDNHQSPGKENGEFDRL 356
Query: 656 MQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSITEHLQVITTLRTAA 715
+ T+ ++K + + ++ LN+++ + E S E+ ++ + +
Sbjct: 357 ARKTSNEKSKVKSQI-----YFTDDLNDISGSSEKTSEDDELPYSDDENFMLL--IEQSG 409
Query: 716 KEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLESEVSVLA 775
E ++ +S L+ + A + + ++K V ++K++++ +SVL
Sbjct: 410 MECKDFVS-----LSKSKNATAACGRSIEDQKCYCERLKV---KFQKMKNN----ISVLQ 457
Query: 776 SKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEVNELLQKFQQAQEELA 835
L E+ K K Q + Q K++ N++ +L+ +E+E + + +++ EEL
Sbjct: 458 KVLSETDKTKS-------QSEHQNLQGKKKLCNLRFILQQQEEERIKAEELYEKDIEELK 510
Query: 836 EMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQLEALQQQ 895
M+ + ++ E K K+ S EV +LK ++ +Q ++ + Q+ ++ +
Sbjct: 511 IMEE--QYRTQTEVKKQSKLTLKSLEV-ELKTVRSNSNQNFHTHERERDLWQENHLMRDE 567
Query: 896 VKQLQNQLAECKKQHQEVISVYRMHLLYAVQGQMDEDVQKVLKQ 939
+ +L+ ++ K Q+QE + Y + + + +ED++K LK+
Sbjct: 568 IARLRLEIDTIKHQNQETENKYFKDI--EIIKENNEDLEKTLKR 609
>gi|38044112 restin isoform b [Homo sapiens]
Length = 1392
Score = 118 bits (296), Expect = 2e-26
Identities = 176/798 (22%), Positives = 345/798 (43%), Gaps = 128/798 (16%)
Query: 226 KLS-ENAGIQSLLLSKISQDADLKTPTKPKQLSDVSSPRS------ITSTPLSGKESVFF 278
KLS EN ++S L +++D+ K K + ++S + ++ + G E+ F
Sbjct: 551 KLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEF 610
Query: 279 AEPPFKAEISSIR-------ENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLT 331
AE K +I +R EN DS A + EA + L+ +++ K SL
Sbjct: 611 AE--LKTQIEKMRLDYQHEIENLQNQQDSERAAHAK---EMEALRAKLMKVIKEKENSLE 665
Query: 332 L-----------HNKELQD---KLQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETSP 377
H E++D KLQ K E ++ + + QT + + TS
Sbjct: 666 AIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEV-LQAKCNEQTKVIDNF-----TSQ 719
Query: 378 PDSKSSPSVLIHSLGKSTTDNDVRIQQLQEILQDLQKRLESSEAERK-------QLQVEL 430
+ + + +L K++++ +++L++ L+ +K+++ E E+ + EL
Sbjct: 720 LKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITREL 779
Query: 431 QSRRAELVCL--NNTEISENSSDLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMD 488
Q R +L L N +E+S+ L ++L+ + K+ EA +E +SVQ+ M+
Sbjct: 780 QGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQ---------- 829
Query: 489 NYSHFHELRVTEEEINVLKQDLQNALEESERNKEKVRELEEKLVEREKGTV-IKPPVEEY 547
++L EE+ N+L DL+ E + K RE +E+ + K ++ + E
Sbjct: 830 --ETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEI 887
Query: 548 EEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKD------------TLKSQMTQ-EA 594
+M S + MN E +E Q ++ K + T+K++ +Q EA
Sbjct: 888 MKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEA 947
Query: 595 SDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLEDVTAEYIHKAEHEK 654
+ + E+ K+ + R + +L K++ +E +A E T+E K +HE+
Sbjct: 948 AKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYER---------ATSET--KTKHEE 996
Query: 655 LMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQK-----ENSVSITEHLQVIT 709
++Q + ED L + + S +L EL +L++ D K E+++ I E +
Sbjct: 997 ILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEK 1056
Query: 710 TLRTAAKE--------MEEKISNLKEHLA------SKEVEVAKLEKQLLEEKAAMTDAMV 755
T A+ E ++ ++ LKE+ +K E+ +E Q +EE + +
Sbjct: 1057 TETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLK 1116
Query: 756 PRSSYEKLQ-SSLESEVSVLASKL---KESVKEKEKVHSEVVQIRSEVSQVKR------- 804
++ + Q S+L+ E LA +L ++ V +K+ E + +++ ++K+
Sbjct: 1117 QAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIK 1176
Query: 805 ----EKENIQ-------TLLKSKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDK 853
EK ++Q LL K+ E+ +L + + E A K LE DK K
Sbjct: 1177 DADEEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVK 1236
Query: 854 KINEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEV 913
++ +LKE LS S +T + + ++ A + Q+ L + + + ++++Q++
Sbjct: 1237 LELKVKNLELQLKENKRQLSSSSGNTDTQADEDER--AQESQIDFLNSVIVDLQRKNQDL 1294
Query: 914 ISVYRMHLLYAVQGQMDE 931
M A+ G D+
Sbjct: 1295 KMKVEMMSEAALNGNGDD 1312
Score = 92.4 bits (228), Expect = 2e-18
Identities = 137/675 (20%), Positives = 289/675 (42%), Gaps = 76/675 (11%)
Query: 257 SDVSSPRSITSTPLSGKESVFFAEPPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQ 316
+ S RS +++ LS SV + + + E R + +G +L + E Q
Sbjct: 303 TSASLKRSPSASSLSSMSSVASSVSSRPSRTGLLTETSSRYARKISGTTALQEALKEKQQ 362
Query: 317 --QDLLS---LLQAKVASLTLHNKELQDKL--------QAKSPKEAEADLSFDSYHSTQT 363
+ LL+ L +A+VA T H E++ +L Q EA+ D +
Sbjct: 363 HIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQLRTMVEAADR 422
Query: 364 DLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDVRIQQLQEI--LQDLQKRLESSEA 421
+ L + E + + + +S T D+ + + E + +L+K L
Sbjct: 423 EKVELLNQLEE----EKRKVEDLQFRVEEESITKGDLEVATVSEKSRIMELEKDLALRVQ 478
Query: 422 ERKQLQVELQSRRAELVCLNNTEISENSSDLSQKLKETQSKYEEAMKEVLSVQKQMKLGL 481
E +L+ L+S + + + + S L +KL+ T++ ++ +E+ S+++
Sbjct: 479 EVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQ---REITSLKEHF---- 531
Query: 482 VSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESERNKEKVRELEEKLVEREKGTVIK 541
+ L E+++ + L++ LE + + V L + +E T I
Sbjct: 532 -GAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLE----TAIA 586
Query: 542 PPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEASDEAEDM 601
+ EE+K S+ + E A L + ++ + + + L++Q E + A++M
Sbjct: 587 SHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEM 646
Query: 602 KEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLEDVTAEYIHKAEHEKLMQLTNV 661
EA+ ++L ++ KE + LE R + + KAE + L+++
Sbjct: 647 -EALR----------AKLMKVIKEKENSLEAIRSK----------LDKAEDQHLVEM--- 682
Query: 662 SRAKAEDALSEMKSQYSKVLN-ELTQLK-----QLVDAQKENSVSITEHLQVITTLRTAA 715
ED L++++ KV E+ Q K +++D + E L + LR A+
Sbjct: 683 -----EDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKAS 737
Query: 716 KEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLESEVSVLA 775
E + ++ L++ L + E ++ LE + E + + E ++L+ +S +
Sbjct: 738 SEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEV- 796
Query: 776 SKLKESV-KEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEVNELLQKFQQAQEEL 834
S++KE++ KE + + + + E V+R + L KE++ N L ++ +E L
Sbjct: 797 SQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENL 856
Query: 835 AEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTSSS-KRQSQQLEALQ 893
A+M+ +K E KD++ ++ K KL+ + + ++S SS + + +L +
Sbjct: 857 ADME------AKFRE-KDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKE 909
Query: 894 QQVKQLQNQLAECKK 908
+ V++LQ +L + +
Sbjct: 910 RDVEELQLKLTKANE 924
>gi|4506751 restin isoform a [Homo sapiens]
Length = 1427
Score = 118 bits (296), Expect = 2e-26
Identities = 176/798 (22%), Positives = 345/798 (43%), Gaps = 128/798 (16%)
Query: 226 KLS-ENAGIQSLLLSKISQDADLKTPTKPKQLSDVSSPRS------ITSTPLSGKESVFF 278
KLS EN ++S L +++D+ K K + ++S + ++ + G E+ F
Sbjct: 586 KLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEF 645
Query: 279 AEPPFKAEISSIR-------ENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLT 331
AE K +I +R EN DS A + EA + L+ +++ K SL
Sbjct: 646 AE--LKTQIEKMRLDYQHEIENLQNQQDSERAAHAK---EMEALRAKLMKVIKEKENSLE 700
Query: 332 L-----------HNKELQD---KLQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETSP 377
H E++D KLQ K E ++ + + QT + + TS
Sbjct: 701 AIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEV-LQAKCNEQTKVIDNF-----TSQ 754
Query: 378 PDSKSSPSVLIHSLGKSTTDNDVRIQQLQEILQDLQKRLESSEAERK-------QLQVEL 430
+ + + +L K++++ +++L++ L+ +K+++ E E+ + EL
Sbjct: 755 LKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITREL 814
Query: 431 QSRRAELVCL--NNTEISENSSDLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMD 488
Q R +L L N +E+S+ L ++L+ + K+ EA +E +SVQ+ M+
Sbjct: 815 QGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQ---------- 864
Query: 489 NYSHFHELRVTEEEINVLKQDLQNALEESERNKEKVRELEEKLVEREKGTV-IKPPVEEY 547
++L EE+ N+L DL+ E + K RE +E+ + K ++ + E
Sbjct: 865 --ETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEI 922
Query: 548 EEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKD------------TLKSQMTQ-EA 594
+M S + MN E +E Q ++ K + T+K++ +Q EA
Sbjct: 923 MKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEA 982
Query: 595 SDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLEDVTAEYIHKAEHEK 654
+ + E+ K+ + R + +L K++ +E +A E T+E K +HE+
Sbjct: 983 AKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYER---------ATSET--KTKHEE 1031
Query: 655 LMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQK-----ENSVSITEHLQVIT 709
++Q + ED L + + S +L EL +L++ D K E+++ I E +
Sbjct: 1032 ILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEK 1091
Query: 710 TLRTAAKE--------MEEKISNLKEHLA------SKEVEVAKLEKQLLEEKAAMTDAMV 755
T A+ E ++ ++ LKE+ +K E+ +E Q +EE + +
Sbjct: 1092 TETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLK 1151
Query: 756 PRSSYEKLQ-SSLESEVSVLASKL---KESVKEKEKVHSEVVQIRSEVSQVKR------- 804
++ + Q S+L+ E LA +L ++ V +K+ E + +++ ++K+
Sbjct: 1152 QAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIK 1211
Query: 805 ----EKENIQ-------TLLKSKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDK 853
EK ++Q LL K+ E+ +L + + E A K LE DK K
Sbjct: 1212 DADEEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVK 1271
Query: 854 KINEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEV 913
++ +LKE LS S +T + + ++ A + Q+ L + + + ++++Q++
Sbjct: 1272 LELKVKNLELQLKENKRQLSSSSGNTDTQADEDER--AQESQIDFLNSVIVDLQRKNQDL 1329
Query: 914 ISVYRMHLLYAVQGQMDE 931
M A+ G D+
Sbjct: 1330 KMKVEMMSEAALNGNGDD 1347
Score = 91.3 bits (225), Expect = 4e-18
Identities = 137/695 (19%), Positives = 293/695 (42%), Gaps = 81/695 (11%)
Query: 257 SDVSSPRSITSTPLSGKESVFFAEPPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQ 316
+ S RS +++ LS SV + + + E R + +G +L + E Q
Sbjct: 303 TSASLKRSPSASSLSSMSSVASSVSSRPSRTGLLTETSSRYARKISGTTALQEALKEKQQ 362
Query: 317 --QDLLS---LLQAKVASLTLHNKELQDKL--------QAKSPKEAEADLSFDSYHSTQT 363
+ LL+ L +A+VA T H E++ +L Q EA+ D +
Sbjct: 363 HIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQLRTMVEAADR 422
Query: 364 DLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDVRIQQLQEILQDLQKRLESSEAER 423
+ L + E V S+ K + +++ + +++L++ L + +
Sbjct: 423 EKVELLNQLEEEKRKVEDLQFRVEEESITKGDLETQTKLEHAR--IKELEQSLLFEKTKA 480
Query: 424 KQLQVELQSRRAELVCLNNTEISENSSDLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVS 483
+LQ EL+ R V + I E DL+ +++E V ++++++ +
Sbjct: 481 DKLQRELEDTRVATVS-EKSRIMELEKDLALRVQE-----------VAELRRRLESNKPA 528
Query: 484 PESMDNYSHFHELRVTEEEINVLKQDLQNALEESERNKEKVRELEEKLVEREKGTVIKPP 543
+ + S E+ +E++ V + D Q + + + E +K ++ +
Sbjct: 529 GDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIK-----ALYTA 583
Query: 544 VEEYEEMKSSYCSVIENMNKEKAFLFE-----------KYQEAQEEIMKLKDT------- 585
E+ + S S +E+ NKE + + +Q+A EE+
Sbjct: 584 TEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETA 643
Query: 586 ----LKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLED 641
LK+Q+ + D +++ N+ E E+ L + +++ K SLE
Sbjct: 644 EFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKE--KENSLEA 701
Query: 642 VTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLN-ELTQLK-----QLVDAQK 695
+ ++ + KAE + L+++ ED L++++ KV E+ Q K +++D
Sbjct: 702 IRSK-LDKAEDQHLVEM--------EDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFT 752
Query: 696 ENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAMV 755
+ E L + LR A+ E + ++ L++ L + E ++ LE + E + +
Sbjct: 753 SQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITR 812
Query: 756 PRSSYEKLQSSLESEVSVLASKLKESV-KEKEKVHSEVVQIRSEVSQVKREKENIQTLLK 814
E ++L+ +S + S++KE++ KE + + + + E V+R + L
Sbjct: 813 ELQGRELKLTNLQENLSEV-SQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLH 871
Query: 815 SKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQ 874
KE++ N L ++ +E LA+M+ +K E KD++ ++ K KL+ + + +
Sbjct: 872 QKEEQFNMLSSDLEKLRENLADME------AKFRE-KDEREEQLIKAKEKLENDIAEIMK 924
Query: 875 LSYSTSSS-KRQSQQLEALQQQVKQLQNQLAECKK 908
+S SS + + +L ++ V++LQ +L + +
Sbjct: 925 MSGDNSSQLTKMNDELRLKERDVEELQLKLTKANE 959
Score = 58.9 bits (141), Expect = 2e-08
Identities = 59/302 (19%), Positives = 128/302 (42%), Gaps = 47/302 (15%)
Query: 662 SRAKAEDALSEMKSQYSKVLNELTQLKQLV--------------DAQKENSVSITEHLQV 707
SR L+E S+Y++ ++ T L++ + D ++ T H+
Sbjct: 328 SRPSRTGLLTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGE 387
Query: 708 ITTLRTAAK--------EMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAMVPRSS 759
I A+ E+E K+ L+ + + + E +L QL EEK + D
Sbjct: 388 IEQELALARDGHDQHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEE 447
Query: 760 YEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQE 819
+ LE++ + +++KE + ++ +++ +++RE E+ + S++
Sbjct: 448 ESITKGDLETQTKLEHARIKE-------LEQSLLFEKTKADKLQRELEDTRVATVSEKSR 500
Query: 820 VNELLQKFQQAQEELAEMKRYAESS----------------SKLEEDKDKKINEMSKEVT 863
+ EL + +E+AE++R ES+ S L+E + + +E+T
Sbjct: 501 IMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREIT 560
Query: 864 KLKEALNSLSQLSYSTSSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLY 923
LKE + + K E L ++ + L+++L K++ +VI++++ L
Sbjct: 561 SLKEHFGAREET--HQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLET 618
Query: 924 AV 925
A+
Sbjct: 619 AI 620
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 117 bits (294), Expect = 4e-26
Identities = 154/733 (21%), Positives = 327/733 (44%), Gaps = 96/733 (13%)
Query: 291 RENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLT--------LHNKELQDKLQ 342
R+ + L T + LD S A QQ+L S + +V L H ++Q+ Q
Sbjct: 1135 RDLGEELEALKTELEDTLD--STAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQ 1192
Query: 343 AKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDVRI 402
S E + + +L + + E + + VL+ G D++ +
Sbjct: 1193 KHSQAVEELAEQLEQTKRVKANLEKAK-QTLENERGELANEVKVLLQGKG----DSEHKR 1247
Query: 403 QQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLN---------NTEISENSSDLS 453
++++ LQ+LQ + E R +L ++ + EL + +++++++ S L
Sbjct: 1248 KKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALE 1307
Query: 454 QKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEI--NVLKQ--- 508
+L++TQ +E ++ LS+ ++K + D + F E EEE N+ KQ
Sbjct: 1308 SQLQDTQELLQEENRQKLSLSTKLK------QVEDEKNSFREQLEEEEEAKHNLEKQIAT 1361
Query: 509 ------DLQNALEESERNKEKVRELEEKLVEREKGTVIK--PPVEEYEEMKSSYCSVIEN 560
D++ +E+S E E++ KL + +G + V Y++++ + + +
Sbjct: 1362 LHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQE 1421
Query: 561 MN---------KEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEASDEAEDMKE------AM 605
++ ++ A EK Q+ ++++ + T+ ++ +E + +E ++
Sbjct: 1422 LDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSL 1481
Query: 606 NRMIDELNKQVSELSQLYKEAQAELEDY---------------RKRKSLEDVTAEYIHKA 650
R ++E +Q +EL +L K+ + E+ED + +++LE E +
Sbjct: 1482 ARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQL 1541
Query: 651 EH-EKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQL-----KQLVDAQKENSVSITEH 704
E E +Q T ++ + E L MK+Q+ + L + KQLV +E + +
Sbjct: 1542 EELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDE 1601
Query: 705 LQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAMVPRSSYEKLQ 764
+ + A K++E + +L+ H+ S + KQL + +A M D M +L
Sbjct: 1602 RKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCM------RELD 1655
Query: 765 SSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEVNELL 824
+ S +LA + KE+ K+ + + +E++Q++ E++ +R K Q + +++ +E+
Sbjct: 1656 DTRASREEILA-QAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQ---QERDELADEIA 1711
Query: 825 QKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTSSSKR 884
+ L E +R ++LEE+ +++ +LK+A + Q++ + +
Sbjct: 1712 NSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERS 1771
Query: 885 QSQQLEALQQQVKQLQNQLAECKKQHQE--VISVYRMHL--LYAVQGQMDEDVQKVLKQI 940
+Q+ E +QQ+++ QN+ + K Q E V S Y+ + L A Q++E + K+
Sbjct: 1772 HAQKNENARQQLER-QNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKER 1830
Query: 941 LTMCK--NQSQKK 951
CK +++KK
Sbjct: 1831 QAACKQVRRTEKK 1843
Score = 103 bits (256), Expect = 1e-21
Identities = 143/691 (20%), Positives = 304/691 (43%), Gaps = 106/691 (15%)
Query: 302 TGADSLLDISSE-----ADQQDLLSLLQAKVASL-------TLHNKELQDKLQAKSPKEA 349
T LL +S + A +++L+ + + ++A+ TL ++ + +KLQ + +A
Sbjct: 832 TKVKPLLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQA 891
Query: 350 EADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDVRIQQLQ--- 406
E +L ++ +L L K + H L + + R Q LQ
Sbjct: 892 ETELCAEA-----EELRARLTA--------KKQELEEICHDLEARVEEEEERCQHLQAEK 938
Query: 407 ----EILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEI--SENSSDLSQKLKETQ 460
+ +Q+L+++LE E+ R++LQ+E + A+L L +I + + L+++ K +
Sbjct: 939 KKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLE 998
Query: 461 SKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESERN 520
+ E + +++ K S+ + HE +T+ E + +++ Q E R
Sbjct: 999 DRIAEFTTNLTEEEEKSK-------SLAKLKNKHEAMITDLEERLRREEKQRQELEKTRR 1051
Query: 521 K---------EKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEK 571
K +++ EL+ ++ E +K + + EE + + +E +K +K
Sbjct: 1052 KLEGDSTDLSDQIAELQAQIAE------LKMQLAKKEEELQAALARVEEEAAQKNMALKK 1105
Query: 572 YQEAQEEIMKLKDTLKSQMT--QEASDEAEDMKEAMNRMIDELNKQV-SELSQLYKEAQA 628
+E + +I +L++ L+S+ +A + D+ E + + EL + S +Q ++
Sbjct: 1106 IRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKR 1165
Query: 629 ELEDYRKRKSLEDVTAEY----------IHKAEHEKLMQLTNVSRAKA--EDALSEMKSQ 676
E E +K+LE+ + +A E QL R KA E A ++++
Sbjct: 1166 EQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENE 1225
Query: 677 YSKVLNELTQL----------KQLVDAQ-KENSVSITEHLQVITTLRTAAKEMEEKISNL 725
++ NE+ L ++ V+AQ +E V E +V T L +++ ++ N+
Sbjct: 1226 RGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNV 1285
Query: 726 KEHLASKEVEVAKLEKQL--LEEKAAMTDAMVPRSSYEKLQSS-----LESEVSVLASKL 778
L+ + + +KL K LE + T ++ + +KL S +E E + +L
Sbjct: 1286 TGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQL 1345
Query: 779 KESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEVNELLQK-----FQQAQEE 833
+E + K + ++ + ++V+ +K++ E+ L++ E EV LQK Q+ +E+
Sbjct: 1346 EEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAE-EVKRKLQKDLEGLSQRHEEK 1404
Query: 834 LAEMKRYAESSSKLEEDKDK---KINEMSKEVTKLKEALNSLSQL--SYSTSSSK----R 884
+A + ++ ++L+++ D ++ + L++ QL T S+K R
Sbjct: 1405 VAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEER 1464
Query: 885 QSQQLEALQQQVK--QLQNQLAECKKQHQEV 913
+ EA +++ K L L E +Q E+
Sbjct: 1465 DRAEAEAREKETKALSLARALEEAMEQKAEL 1495
Score = 84.0 bits (206), Expect = 6e-16
Identities = 131/681 (19%), Positives = 277/681 (40%), Gaps = 132/681 (19%)
Query: 292 ENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLTLHNKELQDKLQAKSPKEAEA 351
E D+++ D++ + S++D + S L ++L ++ Q+ LQ ++ ++
Sbjct: 1270 ELADKVTKLQVELDNVTGLLSQSDSKS--SKLTKDFSALESQLQDTQELLQEENRQKLSL 1327
Query: 352 DLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDVRIQQLQEILQD 411
+ L + E H+L K ++ +++ ++D
Sbjct: 1328 STKLKQVEDEKNSFREQLEEEEEAK------------HNLEKQIATLHAQVADMKKKMED 1375
Query: 412 LQKRLESSEAERKQLQVELQ--SRRAELVCLNNTEISENSSDLSQKLKETQSKYEEAMKE 469
LE++E +++LQ +L+ S+R E ++ + + L Q+L + + +
Sbjct: 1376 SVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQS 1435
Query: 470 VLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESERNKEK-----V 524
+++K+ K F +L E+ I+ + ++ E R KE
Sbjct: 1436 ACNLEKKQK-------------KFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLA 1482
Query: 525 RELEEKLVER-EKGTVIKPPVEEYEEMKSSYCSV---IENMNKEKAFLFEKYQEAQEEIM 580
R LEE + ++ E + K E E++ SS V + + K K L ++ +E + ++
Sbjct: 1483 RALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLE 1542
Query: 581 KLKDTLKSQMTQEASDEAEDMKEAMNRMID--------ELNKQVSELSQLYKEAQAELED 632
+L+D L Q T++A E +AM + + ++ +L + +E +AELED
Sbjct: 1543 ELEDEL--QATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELED 1600
Query: 633 YRKRKS------------LEDVTA--EYIHKAEHEKLMQLTNV-------------SRAK 665
RK++S L+D+ A + +K E + QL + +RA
Sbjct: 1601 ERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRAS 1660
Query: 666 AEDALSEMKSQYSKVLN---ELTQLKQ----------------------LVDAQKENSVS 700
E+ L++ K K+ + E+ QL++ + ++ + +++
Sbjct: 1661 REEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALA 1720
Query: 701 ITEHLQVITTLRTAAKEMEEKISNL------------------------KEHLASKEVEV 736
+ E ++ + +E+EE+ N + H E
Sbjct: 1721 LEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENAR 1780
Query: 737 AKLEKQLLEEKAAMTDAM-VPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEV--- 792
+LE+Q E K + + +S Y+ ++LE++++ L +L KE++ +V
Sbjct: 1781 QQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRT 1840
Query: 793 -VQIRSEVSQVKREKENIQTLLKSKEQEVNELLQKFQQAQEELAEMKRYAESSSKLE--- 848
+++ + QV E+ N + ++ L Q +Q +E E +R S KL+
Sbjct: 1841 EKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQREL 1900
Query: 849 EDKDKKINEMSKEVTKLKEAL 869
ED + + M++EV+ LK L
Sbjct: 1901 EDATETADAMNREVSSLKNKL 1921
Score = 81.3 bits (199), Expect = 4e-15
Identities = 105/586 (17%), Positives = 246/586 (41%), Gaps = 63/586 (10%)
Query: 285 AEISSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLTLHNK-------EL 337
A + + K RL D L+D+ + L Q K L K E
Sbjct: 1406 AAYDKLEKTKTRLQQELD--DLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEE 1463
Query: 338 QDKLQAKSPKEAEADLSF----DSYHSTQTDLGPSLGKPGETSPPD---SKSSPSVLIHS 390
+D+ +A++ ++ LS + + +L L K T D SK +H
Sbjct: 1464 RDRAEAEAREKETKALSLARALEEAMEQKAEL-ERLNKQFRTEMEDLMSSKDDVGKSVHE 1522
Query: 391 LGKSTTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSS 450
L KS + ++++++ L++L+ L+++E + +L+V LQ+ +A+ ++
Sbjct: 1523 LEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQF----ERDLQGRDE 1578
Query: 451 DLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDL 510
+K K+ + E E+ +KQ + + + + ++ +L+ E I+ ++
Sbjct: 1579 QSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEM-----DLKDLEAHIDSANKNR 1633
Query: 511 QNALEESER----NKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKA 566
A+++ + K+ +REL++ RE+ ++ E +++KS +I+ + +E A
Sbjct: 1634 DEAIKQLRKLQAQMKDCMRELDDTRASREE--ILAQAKENEKKLKSMEAEMIQ-LQEELA 1690
Query: 567 FLFEKYQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEA 626
++AQ+E +D L ++ + A ++E L ++++L + +E
Sbjct: 1691 AAERAKRQAQQE----RDELADEIANSSGKGALALEEKRR-----LEARIAQLEEELEEE 1741
Query: 627 QAELEDYRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQ 686
Q E R ++ + I+ + L K E+A +++ Q ++ +L +
Sbjct: 1742 QGNTELINDRLKKANLQIDQINTD-----LNLERSHAQKNENARQQLERQNKELKVKLQE 1796
Query: 687 LKQLVDAQKENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEE 746
++ V ++ + S++ +E KI+ L+E L ++ E KQ+
Sbjct: 1797 MEGTVKSKYKASITA----------------LEAKIAQLEEQLDNETKERQAACKQVRRT 1840
Query: 747 KAAMTDAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREK 806
+ + D ++ + + + +++LK+ ++ E+ E + + +++RE
Sbjct: 1841 EKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQREL 1900
Query: 807 ENIQTLLKSKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKD 852
E+ + +EV+ L K ++ +R A + D++
Sbjct: 1901 EDATETADAMNREVSSLKNKLRRGDLPFVVPRRMARKGAGDGSDEE 1946
>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
Length = 4377
Score = 117 bits (294), Expect = 4e-26
Identities = 90/338 (26%), Positives = 149/338 (44%), Gaps = 26/338 (7%)
Query: 34 KVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLA 93
KV LL K GAS G T H+AA GHV + ++ HG + G +ALH+A
Sbjct: 414 KVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMA 473
Query: 94 AKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGN 153
A++ E +R L+Q E+ +T LH +A G VQ L + + N G
Sbjct: 474 ARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGY 533
Query: 154 IPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADLNL 213
PL L+ + GH ++ FLLDHGA ++ K G T L +A + G L++K A +
Sbjct: 534 TPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDA 593
Query: 214 VDSLGYNALHYSKLSENAGIQSLLLSK-ISQDADLKTPTKPKQLSDVSSPRSITSTPLSG 272
G LH + +N + LLL + S A K P ++ + I +T L
Sbjct: 594 AGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLE- 652
Query: 273 KESVFFAEPPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLTL 332
+ A+ +++ T + + ++++ D++SLL + A++ L
Sbjct: 653 ----------YGADANAV----------TRQGIASVHLAAQEGHVDMVSLLLGRNANVNL 692
Query: 333 HNKELQDKLQAKSPKE----AEADLSFDSYHSTQTDLG 366
NK L + ++ AE ++ ++ QT +G
Sbjct: 693 SNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMG 730
Score = 110 bits (274), Expect = 8e-24
Identities = 70/233 (30%), Positives = 112/233 (48%), Gaps = 2/233 (0%)
Query: 26 AVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTT 85
A + G+A V LL + GA +G T H A GH + + +++ + ++
Sbjct: 275 ASKRGNANMVKLLLDR-GAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKN 333
Query: 86 GHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPI 145
G S LH+A + H C++ LLQ P + V + TALH AA G + ++L + K+
Sbjct: 334 GLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANP 393
Query: 146 NLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALI 205
N K L+G PL +A + ++ LL HGA + + +SG T + +A +G N V L+
Sbjct: 394 NAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLM 453
Query: 206 KKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQ-DADLKTPTKPKQLS 257
GA N + G ALH + S A + L+ +Q +A K P +S
Sbjct: 454 HHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHIS 506
Score = 101 bits (252), Expect = 3e-21
Identities = 67/236 (28%), Positives = 117/236 (49%), Gaps = 9/236 (3%)
Query: 14 NEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMI 73
++ KN D + A E + ++ +K + K S+ ++ AA GH+E I
Sbjct: 6 SQLKKNRDLEINAEEEPEKKRKH----RKRSRDRKKKSDANASYLRAARAGHLEKALDYI 61
Query: 74 THGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQ 133
+GVD+ + G +ALHLA+K H E + +LLQ + ++ G TALH A+ G +
Sbjct: 62 KNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAE 121
Query: 134 AVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLAC 193
V++L + + +N + +G PL +A Q H E+ FLLD+GA + + G T L +A
Sbjct: 122 VVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVAL 181
Query: 194 EIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKT 249
+ G V L++ + + ALH + ++ +LLL +AD+++
Sbjct: 182 QQGHDQVVSLLLEN----DTKGKVRLPALHIAARKDDTKAAALLLQN-DNNADVES 232
Score = 100 bits (249), Expect = 6e-21
Identities = 64/235 (27%), Positives = 110/235 (46%), Gaps = 3/235 (1%)
Query: 18 KNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGV 77
KN L GD LL + ++ TA H+AA GH + +V++
Sbjct: 332 KNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKA 391
Query: 78 DVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQI 137
+ A+ G + LH+A K + + + LL+ ++V SG T +H AA G + V
Sbjct: 392 NPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQ 451
Query: 138 LCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGS 197
L H + N ++ G L +A ++G +E+ +L+ GA V ++ K +T L ++ +G
Sbjct: 452 LMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGK 511
Query: 198 SNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKTPTK 252
++ V+ L+++GA N + GY LH LS G + + + A L TK
Sbjct: 512 ADIVQQLLQQGASPNAATTSGYTPLH---LSAREGHEDVAAFLLDHGASLSITTK 563
Score = 99.4 bits (246), Expect = 1e-20
Identities = 78/301 (25%), Positives = 133/301 (44%), Gaps = 12/301 (3%)
Query: 24 LQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQD 83
L + D +KVA LL +GAS G T H+AA K ++ ++ +G D A
Sbjct: 602 LHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVT 661
Query: 84 TTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKS 143
G +++HLAA+ H + + LL + SG T LH AA + + ++L +
Sbjct: 662 RQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGA 721
Query: 144 PINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEA 203
++ + G PL + G+ +I +FLL H A VN++ K+G T L A + G ++ +
Sbjct: 722 HVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINV 781
Query: 204 LIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKTPTKPKQLSDVSSPR 263
L++ A N + G AL ++ L IS LK T+ + + +
Sbjct: 782 LLQNNASPNELTVNGNTALGIAR----------RLGYISVVDTLKIVTEETMTTTTVTEK 831
Query: 264 SITSTPLSGKESVFFAEPPF-KAEISSIRENKDRLSDSTTGADSLL-DISSEADQQDLLS 321
+ P + E + ++ KA + + + +SD G D++ D QDL
Sbjct: 832 HKMNVPETMNEVLDMSDDEVRKANAPEMLSDGEYISDVEEGEDAMTGDTDKYLGPQDLKE 891
Query: 322 L 322
L
Sbjct: 892 L 892
Score = 97.8 bits (242), Expect = 4e-20
Identities = 61/214 (28%), Positives = 102/214 (47%)
Query: 34 KVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLA 93
+VA+LL +K AS G T H+AA + + +++ G A G++ LH+A
Sbjct: 579 EVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIA 638
Query: 94 AKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGN 153
AK + + LL+ A +V G ++H AA +G + V +L + +NL + G
Sbjct: 639 AKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGL 698
Query: 154 IPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADLNL 213
PL LA Q + L++ GA V+++ K G T L + C G+ V L++ A +N
Sbjct: 699 TPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNA 758
Query: 214 VDSLGYNALHYSKLSENAGIQSLLLSKISQDADL 247
GY LH + + I ++LL + +L
Sbjct: 759 KTKNGYTPLHQAAQQGHTHIINVLLQNNASPNEL 792
Score = 97.1 bits (240), Expect = 7e-20
Identities = 82/311 (26%), Positives = 137/311 (44%), Gaps = 15/311 (4%)
Query: 33 EKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHL 92
E+V +L + A G + H+A H+ C+++++ H V V +ALH+
Sbjct: 314 EQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHV 373
Query: 93 AAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDG 152
AA H++ + LL K + +G T LH A + ++ +++L +H + I G
Sbjct: 374 AAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESG 433
Query: 153 NIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADLN 212
P+ +A GH I L+ HGA N+ N G TAL +A G + V L++ GA +
Sbjct: 434 LTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVE 493
Query: 213 LVDSLGYNALHYS-KLSENAGIQSLLLSKISQDADLKTPTKPKQLS------DVSS---- 261
LH S +L + +Q LL S +A + P LS DV++
Sbjct: 494 AKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLD 553
Query: 262 -PRSITSTPLSGKESVFFAEPPFKAEISSIRENKDRLSDSTTGADSL--LDISSEADQQD 318
S++ T G + A K E++++ K D+ G L L +++ D Q
Sbjct: 554 HGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDA-AGKSGLTPLHVAAHYDNQK 612
Query: 319 LLSLLQAKVAS 329
+ LL + AS
Sbjct: 613 VALLLLDQGAS 623
Score = 94.4 bits (233), Expect = 5e-19
Identities = 68/255 (26%), Positives = 111/255 (43%), Gaps = 21/255 (8%)
Query: 1 MKSLKAKFRKSDTNEWNKNDDRLLQAVENGDAEK-----------------VASLLGKKG 43
+ +L RK DT K LLQ N D E VA+LL +
Sbjct: 203 LPALHIAARKDDT----KAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRA 258
Query: 44 ASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIR 103
A+ T H+A+ +G+ +++++ G + A+ G + LH A++ H + +
Sbjct: 259 AAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVE 318
Query: 104 KLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNG 163
LL P S +G + LH A L VQ+L +H P++ D L +A G
Sbjct: 319 MLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCG 378
Query: 164 HSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALH 223
H ++ LLD A+ N++ +G T L +AC+ +E L+K GA + V G +H
Sbjct: 379 HYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIH 438
Query: 224 YSKLSENAGIQSLLL 238
+ + I S L+
Sbjct: 439 VAAFMGHVNIVSQLM 453
Score = 93.2 bits (230), Expect = 1e-18
Identities = 63/206 (30%), Positives = 93/206 (45%)
Query: 33 EKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHL 92
E VA+ L GAS + +G T H+AA G +E +++ A +G + LH+
Sbjct: 545 EDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHV 604
Query: 93 AAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDG 152
AA + + LL + +G T LH AA + + L E+ + N G
Sbjct: 605 AAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQG 664
Query: 153 NIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADLN 212
+ LA Q GH ++ LL A+VN NKSG T L LA + N E L+ +GA ++
Sbjct: 665 IASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVD 724
Query: 213 LVDSLGYNALHYSKLSENAGIQSLLL 238
+GY LH N I + LL
Sbjct: 725 AQTKMGYTPLHVGCHYGNIKIVNFLL 750
Score = 92.8 bits (229), Expect = 1e-18
Identities = 59/223 (26%), Positives = 102/223 (45%), Gaps = 1/223 (0%)
Query: 18 KNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGV 77
+ + L A +G AE V L+ + GA + +T H++A G + ++ ++ G
Sbjct: 465 RGETALHMAARSGQAEVVRYLV-QDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGA 523
Query: 78 DVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQI 137
A T+G++ LHL+A+ H + LL G T LH AA G L+ +
Sbjct: 524 SPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANL 583
Query: 138 LCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGS 197
L + + + G PL +A + ++ LLD GA ++ K+G T L +A +
Sbjct: 584 LLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQ 643
Query: 198 SNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSK 240
+ L++ GAD N V G ++H + + + SLLL +
Sbjct: 644 MDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGR 686
Score = 90.1 bits (222), Expect = 9e-18
Identities = 65/231 (28%), Positives = 111/231 (48%), Gaps = 8/231 (3%)
Query: 12 DTNEWNKNDDRLLQ-AVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLR 70
D N N+N L A + G E V+ LL ++ A+ +G TA H+A+ G E ++
Sbjct: 66 DINICNQNGLNALHLASKEGHVEVVSELLQRE-ANVDAATKKGNTALHIASLAGQAEVVK 124
Query: 71 VMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQG 130
V++T+G +V AQ G + L++AA+ +H E ++ LL + G T L A QG
Sbjct: 125 VLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQG 184
Query: 131 CLQAVQILCEHKSPINLKDLDGNIPLL-LAVQNGHSEICHFLLDHGADVNSRNKSGRTAL 189
Q V +L E+ + ++ +P L +A + ++ LL + + + +KSG T L
Sbjct: 185 HDQVVSLLLENDTKGKVR-----LPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPL 239
Query: 190 MLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSK 240
+A G+ N L+ + A ++ LH + NA + LLL +
Sbjct: 240 HIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDR 290
Score = 79.0 bits (193), Expect = 2e-14
Identities = 54/235 (22%), Positives = 109/235 (46%), Gaps = 10/235 (4%)
Query: 9 RKSDTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVEC 68
R+++ + K + L +V +L GA+ G T ++AA + H+E
Sbjct: 96 REANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEV 155
Query: 69 LRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKT---ALHY 125
++ ++ +G + G + L +A + H + + LL++ D+ GK ALH
Sbjct: 156 VKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLEN-------DTKGKVRLPALHI 208
Query: 126 AAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSG 185
AA + +A +L ++ + +++ G PL +A G+ + LL+ A V+ ++
Sbjct: 209 AARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARND 268
Query: 186 RTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSK 240
T L +A + G++N V+ L+ +GA ++ G LH S + + +LL +
Sbjct: 269 ITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDR 323
Score = 77.8 bits (190), Expect = 4e-14
Identities = 55/221 (24%), Positives = 104/221 (47%), Gaps = 11/221 (4%)
Query: 23 LLQAVENGDAEKVASLLGKKGASATKHDSEGKT---AFHLAAAKGHVECLRVMITHGVDV 79
L A++ G + V+ LL ++D++GK A H+AA K + +++ + +
Sbjct: 177 LAVALQQGHDQVVSLLL--------ENDTKGKVRLPALHIAARKDDTKAAALLLQNDNNA 228
Query: 80 TAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILC 139
+ +G + LH+AA + LL + + T LH A+ +G V++L
Sbjct: 229 DVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLL 288
Query: 140 EHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSN 199
+ + I+ K DG PL ++GH ++ LLD A + S+ K+G + L +A + N
Sbjct: 289 DRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLN 348
Query: 200 AVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSK 240
V+ L++ ++ V + ALH + + + +LL K
Sbjct: 349 CVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDK 389
Score = 59.3 bits (142), Expect = 2e-08
Identities = 36/130 (27%), Positives = 56/130 (43%)
Query: 9 RKSDTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVEC 68
R ++ N NK+ L D VA +L +GA G T H+ G+++
Sbjct: 686 RNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKI 745
Query: 69 LRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAA 128
+ ++ H V A+ G++ LH AA+ H I LLQ+ + +G TAL A
Sbjct: 746 VNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIARR 805
Query: 129 QGCLQAVQIL 138
G + V L
Sbjct: 806 LGYISVVDTL 815
Score = 49.3 bits (116), Expect = 2e-05
Identities = 119/580 (20%), Positives = 232/580 (40%), Gaps = 90/580 (15%)
Query: 281 PPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLTLHNKELQDK 340
PP S+ + +++DS G D++L+ + Q D Q K + L+ E + +
Sbjct: 2082 PPASMRTSTSEKELCKMADSFFGTDTILESPDDFSQHD-----QDK-SPLSDSGFETRSE 2135
Query: 341 LQAKSPKEAEADLSFDSYHS---------TQTDL-------GPSLGKPGETSPPDSKS-S 383
+P+ AE+ +H T+T++ PS G +T P + S
Sbjct: 2136 KTPSAPQSAESTGPKPLFHEVPIPPVITETRTEVVHVIRSYDPSAGDVPQTQPEEPVSPK 2195
Query: 384 PSVLIHSLGKSTTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNT 443
PS L T + ++ E ++ Q + S E + ++ + + E T
Sbjct: 2196 PSPTFMELEPKPTTSSIK-----EKVKAFQMKASSEEDDHNRVLSKGMRVKEETHITTTT 2250
Query: 444 EISENS----SDLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVT 499
+ +S S++++ET S ++ MK S + K EL
Sbjct: 2251 RMVYHSPPGGEGASERIEETMSVHD-IMKAFQSGRDPSK----------------ELAGL 2293
Query: 500 EEEINVLKQDL-QNALEESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVI 558
E + + D+ ++A E S ++ EK +++ KL ER +I+ +E+ + + + +
Sbjct: 2294 FEHKSAVSPDVHKSAAETSAQHAEKDNQMKPKL-ER----IIEVHIEKGNQAEPTEVIIR 2348
Query: 559 ENMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSE 618
E + ++ ++ + LKD L + E + +E +E E
Sbjct: 2349 ETKKHPEKEMYVYQKDLSRGDINLKDFLPEKHDAFPCSEEQGQQEEEELTAEESLPSYLE 2408
Query: 619 LSQLYKEAQAELEDYRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYS 678
S++ E ED R +A+ I ++ L L+ S +D LSE++ +
Sbjct: 2409 SSRVNTPVSQE-EDSRPS------SAQLISDDSYKTLKLLSQHSIEYHDDELSELRGESY 2461
Query: 679 KVLNELTQLKQLVDAQKENSVSITEHL-QVITTLRTAAKEMEEKISNL-KEHLASK---- 732
+ ++ ++L + + S+T+H + L+ + K EKI+ K+ + SK
Sbjct: 2462 RFAEKMLLSEKLDVSHSDTEESVTDHAGPPSSELQGSDKRSREKIATAPKKEILSKIYKD 2521
Query: 733 --EVEVAKLEKQLLEEKAAM----------TDAMVPRSSYEKLQSSLESEVSVLASKLKE 780
E V K+ K +K + AM R + ++L E + ++
Sbjct: 2522 VSENGVGKVSKDEHFDKVTVLHYSGNVSSPKHAMWMRFTEDRLDRGREK--LIYEDRVDR 2579
Query: 781 SVKEKEKVHSEVVQIRSEVSQVKREK-ENIQTLLKSKEQE 819
+VKE E + +EVSQ R+K E + L+S E++
Sbjct: 2580 TVKEAE-------EKLTEVSQFFRDKTEKLNDELQSPEKK 2612
>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
Length = 919
Score = 117 bits (293), Expect = 5e-26
Identities = 76/236 (32%), Positives = 112/236 (47%), Gaps = 7/236 (2%)
Query: 32 AEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALH 91
+E+ +L K A D +T H+AAA V+C V+I V D G +ALH
Sbjct: 61 SEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALH 120
Query: 92 LAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLD 151
AA N H E + LL + D + ALH+AA G L V +L H + + KD
Sbjct: 121 HAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKK 180
Query: 152 GNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADL 211
G PL A NG + LL+ G +++ N G TAL +AC G V LI GA++
Sbjct: 181 GYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANV 240
Query: 212 NLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKTPTKPKQLSDVSSPRSITS 267
N ++ G+ LH++ S + + LL ++ AD+ +K D SP +T+
Sbjct: 241 NQPNNNGFTPLHFAAASTHGALCLELL--VNNGADVNIQSK-----DGKSPLHMTA 289
Score = 105 bits (261), Expect = 3e-22
Identities = 64/194 (32%), Positives = 95/194 (48%), Gaps = 1/194 (0%)
Query: 30 GDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSA 89
GDAE + LL GA D+ T H A A E ++V+I H DV A+D +
Sbjct: 27 GDAE-IIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVLIKHSADVNARDKNWQTP 85
Query: 90 LHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKD 149
LH+AA N +C ++ D G+TALH+AA G ++ V +L + IN D
Sbjct: 86 LHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLLLAKGANINAFD 145
Query: 150 LDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGA 209
L A GH ++ L++HGA+V ++K G T L A G N V+ L+ G
Sbjct: 146 KKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGV 205
Query: 210 DLNLVDSLGYNALH 223
+++ ++ G ALH
Sbjct: 206 EIDEINVYGNTALH 219
Score = 102 bits (254), Expect = 2e-21
Identities = 67/214 (31%), Positives = 101/214 (47%), Gaps = 1/214 (0%)
Query: 11 SDTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLR 70
+D N +KN L A K A ++ +S D G+TA H AA GHVE +
Sbjct: 73 ADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVN 132
Query: 71 VMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQG 130
+++ G ++ A D ALH AA H + + L+ D G T LH AA+ G
Sbjct: 133 LLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNG 192
Query: 131 CLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTAL- 189
+ V+ L I+ ++ GN L +A NG + + L+D+GA+VN N +G T L
Sbjct: 193 QINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLH 252
Query: 190 MLACEIGSSNAVEALIKKGADLNLVDSLGYNALH 223
A + +E L+ GAD+N+ G + LH
Sbjct: 253 FAAASTHGALCLELLVNNGADVNIQSKDGKSPLH 286
Score = 101 bits (251), Expect = 4e-21
Identities = 59/190 (31%), Positives = 95/190 (50%)
Query: 50 DSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSK 109
DSE +T H+AA G E + ++I G V A+D + LH A + E ++ L++
Sbjct: 13 DSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVLIKHS 72
Query: 110 CPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICH 169
+ D + +T LH AAA ++ +++ S +N+ D G L A NGH E+ +
Sbjct: 73 ADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVN 132
Query: 170 FLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSE 229
LL GA++N+ +K R AL A +G + V LI GA++ D GY LH + +
Sbjct: 133 LLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNG 192
Query: 230 NAGIQSLLLS 239
+ LL+
Sbjct: 193 QINVVKHLLN 202
Score = 97.1 bits (240), Expect = 7e-20
Identities = 69/239 (28%), Positives = 106/239 (44%), Gaps = 31/239 (12%)
Query: 50 DSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSK 109
D +G T H+AA GH + + T G D LHLAA N+H +C RKLL S
Sbjct: 311 DKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSG 370
Query: 110 CPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICH 169
++ D G+T LH AAA G ++ +++L + + KD G PL A N H
Sbjct: 371 FEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIE 430
Query: 170 FLLDHGADVNSRNKSGRTALMLAC----------------------------EIGSSNAV 201
L+ GA+VN + GRTAL A E ++ +
Sbjct: 431 TLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERARELKEKEATLCL 490
Query: 202 EALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKIS---QDADLKTPTKPKQLS 257
E L++ A+ ++ D GYN++HY+ + LLL + + +++D P L+
Sbjct: 491 EFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLA 549
Score = 94.0 bits (232), Expect = 6e-19
Identities = 75/269 (27%), Positives = 116/269 (43%), Gaps = 41/269 (15%)
Query: 19 NDDRLLQAVENGDAEKVASL--LGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHG 76
N + L +A E + E L L + A+ + D EG + H AAA GH +CL +++
Sbjct: 471 NSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERT 530
Query: 77 VDVTAQDTTG--HSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQG---- 130
+ +G S LHLAA N HH+ + LLQS + D G+TAL AA +G
Sbjct: 531 NSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTEC 590
Query: 131 ---------------------------------CLQAVQILCEHKSPINLKDLDGNIPLL 157
CL+ + + ++ +++KD G PL+
Sbjct: 591 VEALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLM 650
Query: 158 LAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSL 217
LAV GH + LL+ A+V++ + G TAL G V+ L+++ + DS
Sbjct: 651 LAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSR 710
Query: 218 GYNALHYSKLSENAGIQSLLLSKISQDAD 246
G LHY+ +A S LL + D
Sbjct: 711 GRTPLHYAAARGHATWLSELLQMALSEED 739
Score = 88.6 bits (218), Expect = 3e-17
Identities = 70/238 (29%), Positives = 100/238 (42%), Gaps = 35/238 (14%)
Query: 26 AVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGH-VECLRVMITHGVDVTAQDT 84
A NG V L+ GA+ + ++ G T H AAA H CL +++ +G DV Q
Sbjct: 221 ACYNGQDAVVNELIDY-GANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSK 279
Query: 85 TGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSP 144
G S LH+ A + + L+Q+ + VD G T LH AA G + L +
Sbjct: 280 DGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGAD 339
Query: 145 INLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIG-------- 196
+ PL LA N HS+ C LL G ++++ +K GRT L A G
Sbjct: 340 TAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLL 399
Query: 197 -SSNA------------------------VEALIKKGADLNLVDSLGYNALHYSKLSE 229
SS A +E L+ GA++N D G ALHY+ S+
Sbjct: 400 QSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASD 457
Score = 87.4 bits (215), Expect = 6e-17
Identities = 64/234 (27%), Positives = 93/234 (39%), Gaps = 35/234 (14%)
Query: 26 AVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTT 85
A NG V LL G + + G TA H+A G + +I +G +V +
Sbjct: 188 AASNGQINVVKHLLNL-GVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNN 246
Query: 86 GHSALHLAAKNSHHE-CIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSP 144
G + LH AA ++H C+ L+ + GK+ LH A G Q L ++
Sbjct: 247 GFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGE 306
Query: 145 INLKDLDGNI---------------------------------PLLLAVQNGHSEICHFL 171
I+ D DGN PL LA N HS+ C L
Sbjct: 307 IDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKL 366
Query: 172 LDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYS 225
L G ++++ +K GRT L A G+ ++ L GAD + D G LHY+
Sbjct: 367 LSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYA 420
Score = 85.9 bits (211), Expect = 2e-16
Identities = 66/243 (27%), Positives = 103/243 (42%), Gaps = 42/243 (17%)
Query: 50 DSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSK 109
D++G+T LA A GH++ + +++ +V D G +ALH H EC++ LL+ +
Sbjct: 642 DAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQE 701
Query: 110 CPAESVDSSGKTALHYAAAQG---CLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSE 166
DS G+T LHYAAA+G L + + + KD G PL A NG+
Sbjct: 702 VSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNEN 761
Query: 167 I----------------------CHFLLDHG------------ADVNSRNKSGRTALMLA 192
C + DHG + V+ R+ GRT L A
Sbjct: 762 CIEVLLEQKCFRKFIGNPFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAA 821
Query: 193 CEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKIS-----QDADL 247
++ L++ A +N VD+ G AL + + AG +L++ +D DL
Sbjct: 822 AFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDL 881
Query: 248 KTP 250
TP
Sbjct: 882 NTP 884
Score = 81.3 bits (199), Expect = 4e-15
Identities = 61/231 (26%), Positives = 99/231 (42%), Gaps = 39/231 (16%)
Query: 23 LLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGV---DV 79
L + + G E V LL ++ + K DS G+T H AAA+GH L ++ + D
Sbjct: 682 LHRGIMTGHEECVQMLLEQEVSILCK-DSRGRTPLHYAAARGHATWLSELLQMALSEEDC 740
Query: 80 TAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESV------------------------ 115
+D G++ LH A N + CI LL+ KC + +
Sbjct: 741 CFKDNQGYTPLHWACYNGNENCIEVLLEQKCFRKFIGNPFTPLHCAIINDHGNCASLLLG 800
Query: 116 ----------DSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHS 165
D G+T L AA ++ +Q+L H +P+N D G L++A +NG +
Sbjct: 801 AIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQA 860
Query: 166 EICHFLLDHG-ADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADLNLVD 215
L++ AD+ ++K T L LAC G ++ K D +L++
Sbjct: 861 GAVDILVNSAQADLTVKDKDLNTPLHLACSKGHEKCALLILDKIQDESLIN 911
Score = 76.6 bits (187), Expect = 1e-13
Identities = 49/162 (30%), Positives = 79/162 (48%)
Query: 78 DVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQI 137
DV D+ + LH+AA E I L+ S + D+ T LH A A +AVQ+
Sbjct: 8 DVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQV 67
Query: 138 LCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGS 197
L +H + +N +D + PL +A N + ++ + VN ++ GRTAL A G
Sbjct: 68 LIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGH 127
Query: 198 SNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLS 239
V L+ KGA++N D ALH++ + + +LL++
Sbjct: 128 VEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLIN 169
Score = 73.2 bits (178), Expect = 1e-12
Identities = 56/169 (33%), Positives = 81/169 (47%), Gaps = 10/169 (5%)
Query: 26 AVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVD---VTAQ 82
A NG+ + LL +K K T H A H C +++ +D V+ +
Sbjct: 754 ACYNGNENCIEVLLEQK--CFRKFIGNPFTPLHCAIINDHGNCASLLLG-AIDSSIVSCR 810
Query: 83 DTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEH- 141
D G + L AA H EC++ LL+ P +VD+SGKTAL AA G AV IL
Sbjct: 811 DDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNSA 870
Query: 142 KSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGAD---VNSRNKSGRT 187
++ + +KD D N PL LA GH + +LD D +N +N + +T
Sbjct: 871 QADLTVKDKDLNTPLHLACSKGHEKCALLILDKIQDESLINEKNNALQT 919
Score = 66.2 bits (160), Expect = 1e-10
Identities = 41/127 (32%), Positives = 69/127 (54%)
Query: 114 SVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLD 173
++DS +T LH AA G + +++L + +N KD PL AV + E L+
Sbjct: 11 TLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVLIK 70
Query: 174 HGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGI 233
H ADVN+R+K+ +T L +A + E +I + +N+ D G ALH++ L+ + +
Sbjct: 71 HSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEM 130
Query: 234 QSLLLSK 240
+LLL+K
Sbjct: 131 VNLLLAK 137
Score = 44.3 bits (103), Expect = 5e-04
Identities = 31/103 (30%), Positives = 49/103 (47%), Gaps = 1/103 (0%)
Query: 141 HKSP-INLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSN 199
HK+ +N D + PL +A G +EI L+ GA VN+++ T L A S
Sbjct: 4 HKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEE 63
Query: 200 AVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKIS 242
AV+ LIK AD+N D LH + ++ +++ +S
Sbjct: 64 AVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLS 106
Score = 39.7 bits (91), Expect = 0.014
Identities = 20/57 (35%), Positives = 28/57 (49%)
Query: 17 NKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMI 73
N L+ A ENG A V L+ A T D + T HLA +KGH +C +++
Sbjct: 845 NSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHLACSKGHEKCALLIL 901
>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
Length = 1429
Score = 117 bits (293), Expect = 5e-26
Identities = 70/209 (33%), Positives = 104/209 (49%), Gaps = 1/209 (0%)
Query: 17 NKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHG 76
N LL A G A V +LL GA+ DSEG+T +A+A+G+VE +R ++ G
Sbjct: 779 NNGRTPLLAAASMGHASVVNTLLFW-GAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRG 837
Query: 77 VDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQ 136
+D +D G + LH+AA H L++ +D+ G+ A+ +G VQ
Sbjct: 838 LDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQ 897
Query: 137 ILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIG 196
IL E+KS I+ + DG L +A GH +I L HGADVN ++ GR L +
Sbjct: 898 ILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALEN 957
Query: 197 SSNAVEALIKKGADLNLVDSLGYNALHYS 225
E ++ GA++ D+ G ALH S
Sbjct: 958 QLTMAEYFLENGANVEASDAEGRTALHVS 986
Score = 115 bits (287), Expect = 3e-25
Identities = 99/379 (26%), Positives = 176/379 (46%), Gaps = 21/379 (5%)
Query: 13 TNEWNKNDDRL--LQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLR 70
TNE + ND R+ + A + G + V LL K ++ + +G+ A +AA +GH + +
Sbjct: 873 TNEID-NDGRIPFILASQEGHYDCVQILLENK-SNIDQRGYDGRNALRVAALEGHRDIVE 930
Query: 71 VMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQG 130
++ +HG DV +D G L++ A + L++ E+ D+ G+TALH + QG
Sbjct: 931 LLFSHGADVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQG 990
Query: 131 CLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALM 190
++ VQ+L + + +N D + L A GH ++ L++HGA V+ G TAL
Sbjct: 991 HMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALC 1050
Query: 191 LACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKTP 250
+A + G + V+ L++ GAD N D G A+ + + ++ I LL + + +P
Sbjct: 1051 IAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGASSLNGCSP 1110
Query: 251 T-----KPKQLSDVSSP-RSIT-STPLSGKESVFFAEPPFKA-------EISSIRENKDR 296
+ + K L +SS +S+T + SG +P + SS E+ D
Sbjct: 1111 SPVHTMEQKPLQSLSSKVQSLTIKSNSSGSTGGGDMQPSLRGLPNGPTHAFSSPSESPDS 1170
Query: 297 LSD--STTGADSLLDISSEADQQDLLSLLQAKVASL-TLHNKELQDKLQAKSPKEAEADL 353
D ++ +++ L S + + S A+ + + HN +++Q S + +
Sbjct: 1171 TVDRQKSSLSNNSLKSSKNSSLRTTSSTATAQTVPIDSFHNLSFTEQIQQHSLPRSRSRQ 1230
Query: 354 SFDSYHSTQTDLGPSLGKP 372
S S ST LG S P
Sbjct: 1231 SIVSPSSTTQSLGQSHNSP 1249
Score = 111 bits (278), Expect = 3e-24
Identities = 74/233 (31%), Positives = 110/233 (47%), Gaps = 5/233 (2%)
Query: 11 SDTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLR 70
+ N+ + N LL + V +LL +GA D+ G T LAA +GH + +
Sbjct: 536 ASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVN 595
Query: 71 VMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQG 130
+I G ++ D G +AL AA H E + LL + + D+ +TAL AA G
Sbjct: 596 CLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGG 655
Query: 131 CLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALM 190
V L +H + +N D +G L+ A GH EI LLDHGA+VN + GRTAL
Sbjct: 656 HEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALS 715
Query: 191 LA-----CEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLL 238
+A G ++ V LI +GA+++ D G L + + + LLL
Sbjct: 716 VAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLL 768
Score = 110 bits (276), Expect = 5e-24
Identities = 81/247 (32%), Positives = 120/247 (48%), Gaps = 16/247 (6%)
Query: 17 NKNDDR----LLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVM 72
N DDR + QA+E D+ + +LL GAS + DS G+T AA G ++ + ++
Sbjct: 508 NSEDDRTSCIVRQALEREDS--IRTLLDN-GASVNQCDSNGRTLLANAAYSGSLDVVNLL 564
Query: 73 ITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCL 132
++ G D+ +D GH+ L LAA+ H + + L+ D G TAL AA G
Sbjct: 565 VSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHT 624
Query: 133 QAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLA 192
+ V L ++ D D L A GH +I LL HGA+VN + GRTAL+ A
Sbjct: 625 EVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAA 684
Query: 193 CEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKL-----SENAGIQSLLLSKISQ---- 243
+G VE L+ GA++N D G AL + L +A + SLL+ + ++
Sbjct: 685 AYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHC 744
Query: 244 DADLKTP 250
D D TP
Sbjct: 745 DKDGMTP 751
Score = 109 bits (273), Expect = 1e-23
Identities = 73/240 (30%), Positives = 113/240 (47%), Gaps = 10/240 (4%)
Query: 6 AKFRKSDTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGH 65
A +D + W L A G E V++LL G D++ +TA AA GH
Sbjct: 602 ANINHTDQDGWTA----LRSAAWGGHTEVVSALL-YAGVKVDCADADSRTALRAAAWGGH 656
Query: 66 VECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHY 125
+ + ++ HG +V D G +AL AA H E + LL D G+TAL
Sbjct: 657 EDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSV 716
Query: 126 AA-----AQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNS 180
AA ++G V +L + + ++ D DG PLL+A GH ++ LL+ GADV+
Sbjct: 717 AALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDH 776
Query: 181 RNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSK 240
+ +GRT L+ A +G ++ V L+ GA ++ +DS G L + N + LL +
Sbjct: 777 TDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDR 836
Score = 108 bits (271), Expect = 2e-23
Identities = 68/205 (33%), Positives = 100/205 (48%), Gaps = 5/205 (2%)
Query: 24 LQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQD 83
L+A G E + L + GA K D+EG+TA AA GH E + ++ HG +V +D
Sbjct: 648 LRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHED 707
Query: 84 TTGHSALHLAA-----KNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQIL 138
G +AL +AA H + L+ + D G T L AA +G + V +L
Sbjct: 708 VDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLL 767
Query: 139 CEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSS 198
E + ++ D +G PLL A GH+ + + LL GA V+S + GRT L +A G+
Sbjct: 768 LEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNV 827
Query: 199 NAVEALIKKGADLNLVDSLGYNALH 223
V L+ +G D N D G+ LH
Sbjct: 828 EVVRTLLDRGLDENHRDDAGWTPLH 852
Score = 106 bits (264), Expect = 1e-22
Identities = 67/205 (32%), Positives = 103/205 (50%)
Query: 35 VASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAA 94
V SLL +GA D +G T +AA +GHV+ + +++ G DV D G + L AA
Sbjct: 730 VVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAA 789
Query: 95 KNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNI 154
H + LL +S+DS G+T L A+AQG ++ V+ L + N +D G
Sbjct: 790 SMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWT 849
Query: 155 PLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADLNLV 214
PL +A GH IC L++ GA N + GR +LA + G + V+ L++ ++++
Sbjct: 850 PLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQR 909
Query: 215 DSLGYNALHYSKLSENAGIQSLLLS 239
G NAL + L + I LL S
Sbjct: 910 GYDGRNALRVAALEGHRDIVELLFS 934
Score = 104 bits (259), Expect = 4e-22
Identities = 63/213 (29%), Positives = 102/213 (47%), Gaps = 1/213 (0%)
Query: 26 AVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTT 85
A G+ E V +LL + G D G T H+AA +GH +I G D
Sbjct: 821 ASAQGNVEVVRTLLDR-GLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDND 879
Query: 86 GHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPI 145
G LA++ H++C++ LL++K + G+ AL AA +G V++L H + +
Sbjct: 880 GRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADV 939
Query: 146 NLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALI 205
N KD DG L + + + L++GA+V + + GRTAL ++C G V+ LI
Sbjct: 940 NCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLI 999
Query: 206 KKGADLNLVDSLGYNALHYSKLSENAGIQSLLL 238
AD+N D+ +AL + + + LL+
Sbjct: 1000 AYHADVNAADNEKRSALQSAAWQGHVKVVQLLI 1032
Score = 102 bits (254), Expect = 2e-21
Identities = 66/201 (32%), Positives = 98/201 (48%), Gaps = 1/201 (0%)
Query: 23 LLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQ 82
LL A G + V LL + GA D+ G+T AA+ GH + ++ G V +
Sbjct: 752 LLVAAYEGHVD-VVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSI 810
Query: 83 DTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHK 142
D+ G + L +A+ + E +R LL D +G T LH AA +G + L E
Sbjct: 811 DSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQG 870
Query: 143 SPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVE 202
+ N D DG IP +LA Q GH + LL++ ++++ R GR AL +A G + VE
Sbjct: 871 ARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVE 930
Query: 203 ALIKKGADLNLVDSLGYNALH 223
L GAD+N D+ G L+
Sbjct: 931 LLFSHGADVNCKDADGRPTLY 951
Score = 93.2 bits (230), Expect = 1e-18
Identities = 69/218 (31%), Positives = 105/218 (48%), Gaps = 10/218 (4%)
Query: 6 AKFRKSDTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAA---- 61
A+ K+D N+ L+ A G E V LL GA D +G+TA +AA
Sbjct: 668 AEVNKAD----NEGRTALIAAAYMGHREIVEHLLDH-GAEVNHEDVDGRTALSVAALCVP 722
Query: 62 -AKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGK 120
+KGH + ++I G +V D G + L +AA H + + LL+ + D++G+
Sbjct: 723 ASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGR 782
Query: 121 TALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNS 180
T L AA+ G V L + ++ D +G L +A G+ E+ LLD G D N
Sbjct: 783 TPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENH 842
Query: 181 RNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLG 218
R+ +G T L +A G EALI++GA N +D+ G
Sbjct: 843 RDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDG 880
Score = 58.5 bits (140), Expect = 3e-08
Identities = 35/114 (30%), Positives = 58/114 (50%), Gaps = 2/114 (1%)
Query: 11 SDTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLR 70
+D N + LQ+ KV LL + GA ++G TA +AA +GH++ ++
Sbjct: 1003 ADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQ 1062
Query: 71 VMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALH 124
V++ HG D D G +A+ +AAKN H + I+ L K A S++ + +H
Sbjct: 1063 VLLEHGADPNHADQFGRTAMRVAAKNGHSQIIK--LLEKYGASSLNGCSPSPVH 1114
>gi|89363047 death-associated protein kinase 1 [Homo sapiens]
Length = 1430
Score = 115 bits (288), Expect = 2e-25
Identities = 64/202 (31%), Positives = 107/202 (52%), Gaps = 1/202 (0%)
Query: 23 LLQAVENGDAEKVASLLGK-KGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTA 81
++ A+ + + + LLG + + G +AA G+++ L+++I G +
Sbjct: 348 IIHAINDDNVPGLQHLLGSLSNYDVNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDV 407
Query: 82 QDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEH 141
QD G +A++ AA++ H + ++ L ++KCP + D SG+ ALH AA G Q+LC
Sbjct: 408 QDKGGSNAVYWAARHGHVDTLKFLSENKCPLDVKDKSGEMALHVAARYGHADVAQLLCSF 467
Query: 142 KSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAV 201
S N++D + PL A +G+ + L + G +VN +N+ G T L+ A G + V
Sbjct: 468 GSNPNIQDKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKNREGETPLLTASARGYHDIV 527
Query: 202 EALIKKGADLNLVDSLGYNALH 223
E L + GADLN D G+ ALH
Sbjct: 528 ECLAEHGADLNACDKDGHIALH 549
Score = 105 bits (261), Expect = 3e-22
Identities = 65/223 (29%), Positives = 103/223 (46%)
Query: 1 MKSLKAKFRKSDTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLA 60
++ L D N+ NK+ L ++ LL K+G+ D G A + A
Sbjct: 360 LQHLLGSLSNYDVNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWA 419
Query: 61 AAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGK 120
A GHV+ L+ + + + +D +G ALH+AA+ H + + L D +
Sbjct: 420 ARHGHVDTLKFLSENKCPLDVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEE 479
Query: 121 TALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNS 180
T LH AA G + LCE +N+K+ +G PLL A G+ +I L +HGAD+N+
Sbjct: 480 TPLHCAAWHGYYSVAKALCEAGCNVNIKNREGETPLLTASARGYHDIVECLAEHGADLNA 539
Query: 181 RNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALH 223
+K G AL LA ++ L+ +G ++ D G LH
Sbjct: 540 CDKDGHIALHLAVRRCQMEVIKTLLSQGCFVDYQDRHGNTPLH 582
Score = 96.7 bits (239), Expect = 9e-20
Identities = 58/184 (31%), Positives = 96/184 (52%), Gaps = 3/184 (1%)
Query: 50 DSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSK 109
D G+ A H+AA GH + +++ + G + QD + LH AA + ++ + L ++
Sbjct: 442 DKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKALCEAG 501
Query: 110 CPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICH 169
C + G+T L A+A+G V+ L EH + +N D DG+I L LAV+ E+
Sbjct: 502 CNVNIKNREGETPLLTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIK 561
Query: 170 FLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSE 229
LL G V+ +++ G T L +AC+ G+ V AL + +L++ + G LH L+
Sbjct: 562 TLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLH---LAA 618
Query: 230 NAGI 233
N GI
Sbjct: 619 NNGI 622
Score = 93.6 bits (231), Expect = 8e-19
Identities = 58/182 (31%), Positives = 86/182 (47%)
Query: 11 SDTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLR 70
S+ N +K ++ L VA L + G + + EG+T A+A+G+ + +
Sbjct: 469 SNPNIQDKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKNREGETPLLTASARGYHDIVE 528
Query: 71 VMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQG 130
+ HG D+ A D GH ALHLA + E I+ LL C + D G T LH A G
Sbjct: 529 CLAEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDG 588
Query: 131 CLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALM 190
+ V LCE +++ + G PL LA NG ++ +L GA V + G+TA
Sbjct: 589 NMPIVVALCEANCNLDISNKYGRTPLHLAANNGILDVVRYLCLMGASVEALTTDGKTAED 648
Query: 191 LA 192
LA
Sbjct: 649 LA 650
Score = 80.1 bits (196), Expect = 9e-15
Identities = 55/212 (25%), Positives = 97/212 (45%), Gaps = 1/212 (0%)
Query: 26 AVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTT 85
A G A+ VA LL G++ D E +T H AA G+ + + G +V ++
Sbjct: 452 AARYGHAD-VAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKNRE 510
Query: 86 GHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPI 145
G + L A+ +H+ + L + + D G ALH A + ++ ++ L +
Sbjct: 511 GETPLLTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLSQGCFV 570
Query: 146 NLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALI 205
+ +D GN PL +A ++G+ I L + +++ NK GRT L LA G + V L
Sbjct: 571 DYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLHLAANNGILDVVRYLC 630
Query: 206 KKGADLNLVDSLGYNALHYSKLSENAGIQSLL 237
GA + + + G A ++ ++ + LL
Sbjct: 631 LMGASVEALTTDGKTAEDLARSEQHEHVAGLL 662
Score = 44.7 bits (104), Expect = 4e-04
Identities = 31/110 (28%), Positives = 54/110 (49%), Gaps = 4/110 (3%)
Query: 145 INLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEAL 204
+N + G PLL+A G+ +I L+ G+ ++ ++K G A+ A G + ++ L
Sbjct: 372 VNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKFL 431
Query: 205 IKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKIS----QDADLKTP 250
+ L++ D G ALH + +A + LL S S QD + +TP
Sbjct: 432 SENKCPLDVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETP 481
Score = 42.0 bits (97), Expect = 0.003
Identities = 31/120 (25%), Positives = 53/120 (44%), Gaps = 2/120 (1%)
Query: 11 SDTNEWNKNDDRLLQ-AVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECL 69
+D N +K+ L AV E + +LL + G D G T H+A G++ +
Sbjct: 535 ADLNACDKDGHIALHLAVRRCQMEVIKTLLSQ-GCFVDYQDRHGNTPLHVACKDGNMPIV 593
Query: 70 RVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQ 129
+ ++ + G + LHLAA N + +R L E++ + GKTA A ++
Sbjct: 594 VALCEANCNLDISNKYGRTPLHLAANNGILDVVRYLCLMGASVEALTTDGKTAEDLARSE 653
Score = 37.7 bits (86), Expect = 0.051
Identities = 17/49 (34%), Positives = 31/49 (63%)
Query: 177 DVNSRNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYS 225
DVN NK G L++A G+ ++ LIK+G+ +++ D G NA++++
Sbjct: 371 DVNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWA 419
>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
Length = 1053
Score = 113 bits (283), Expect = 7e-25
Identities = 66/218 (30%), Positives = 104/218 (47%)
Query: 32 AEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALH 91
+E+ +L K A D +T H+AAA V+C ++ +V D G +ALH
Sbjct: 86 SEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALH 145
Query: 92 LAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLD 151
AA + H E ++ LL + D + A+H+AA G ++ V++L H + + KD
Sbjct: 146 HAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKK 205
Query: 152 GNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADL 211
PL A +G + +LLD G D+N N G T L +AC G V LI GA +
Sbjct: 206 SYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIV 265
Query: 212 NLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKT 249
N + G+ LH++ S + + LL D ++K+
Sbjct: 266 NQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKS 303
Score = 113 bits (282), Expect = 1e-24
Identities = 86/274 (31%), Positives = 122/274 (44%), Gaps = 47/274 (17%)
Query: 23 LLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQ 82
L+ +V NG + V SLL K GA+ D G+TA H A GH EC+ ++ HG +
Sbjct: 657 LMLSVLNGHTDCVYSLLNK-GANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLR 715
Query: 83 DTTGHSALHLAAKNSHHECIRKLLQSKCPAES----VDSSGKTALHYAAAQGCLQAVQIL 138
D+ G + +HL+A H + LLQS ++ D+ G TALH+A G V++L
Sbjct: 716 DSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELL 775
Query: 139 CEHK----------------------------------SPINLKDLDGNIPLLLAVQNGH 164
E + S +N D G PL A H
Sbjct: 776 LEQEVFQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDH 835
Query: 165 SEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKK-GADLNLVDSLGYNALH 223
E LL H A VNS + +G+T LM+A E G +N VE L+ A+L L D+ ALH
Sbjct: 836 VECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALH 895
Query: 224 YSKLSENAGIQSLLLSKISQ-------DADLKTP 250
+ + L+L KI+ +A L+TP
Sbjct: 896 LACSKGHETSALLILEKITDRNLINATNAALQTP 929
Score = 110 bits (276), Expect = 5e-24
Identities = 74/253 (29%), Positives = 121/253 (47%), Gaps = 16/253 (6%)
Query: 18 KNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGV 77
++ L+QA+ NGD ++V +L+ KK D+E +T H AA G E + ++I G
Sbjct: 7 RDQPSLVQAIFNGDPDEVRALIFKK-EDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGA 65
Query: 78 DVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQI 137
V A+D+ + LH A + E ++ LL+ + D + +T LH AAA ++ +
Sbjct: 66 RVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEA 125
Query: 138 LCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGS 197
L S +N+ D G L A +GH E+ LL GA++N+ +K R A+ A +G
Sbjct: 126 LVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGH 185
Query: 198 SNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKTPTKPKQLS 257
V+ L+ GA++ D Y LH A S ++S + DL
Sbjct: 186 IEVVKLLVSHGAEVTCKDKKSYTPLH-------AAASSGMISVVKYLLDLGV-------- 230
Query: 258 DVSSPRSITSTPL 270
D++ P + +TPL
Sbjct: 231 DMNEPNAYGNTPL 243
Score = 107 bits (266), Expect = 7e-23
Identities = 76/231 (32%), Positives = 109/231 (47%), Gaps = 4/231 (1%)
Query: 41 KKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHE 100
+ GA D G T H+AA GH + +IT G D + G LHLAA + +
Sbjct: 327 QSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSD 386
Query: 101 CIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAV 160
C RKLL S ++ D G+T LH AAA G L+ + +L + N KD G PL A
Sbjct: 387 CCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAA 446
Query: 161 QNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSN-AVEALIKKGADLNLVDSLGY 219
N + + L+ GA VN ++ G T L A + +E L++ A+ + D GY
Sbjct: 447 ANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGY 506
Query: 220 NALHYSKLSENAGIQSLLLSKISQDADLKTPTKPKQLSDVSSPRSITSTPL 270
NA+HYS + L+ S+ D ++T + LSD S T +PL
Sbjct: 507 NAVHYSAAYGHRLCLQLIASETPLDVLMET-SGTDMLSD--SDNRATISPL 554
Score = 104 bits (260), Expect = 3e-22
Identities = 67/197 (34%), Positives = 109/197 (55%), Gaps = 5/197 (2%)
Query: 58 HLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDS 117
HLAA GH + L V++ +D+ ++++G + L LAA H EC+ L+ D
Sbjct: 555 HLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDY 614
Query: 118 SGK-TALHYAAAQGCLQAVQILCEHKSP---INLKDLDGNIPLLLAVQNGHSEICHFLLD 173
K T +H AA G + +++L + P ++++D +G PL+L+V NGH++ + LL+
Sbjct: 615 ILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLN 674
Query: 174 HGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGI 233
GA+V++++K GRTAL G V+AL++ GA L DS G +H S + G+
Sbjct: 675 KGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGV 734
Query: 234 -QSLLLSKISQDADLKT 249
+LL S S DA+ T
Sbjct: 735 LGALLQSAASMDANPAT 751
Score = 102 bits (254), Expect = 2e-21
Identities = 67/218 (30%), Positives = 102/218 (46%), Gaps = 1/218 (0%)
Query: 11 SDTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLR 70
+D N +KN L A K A L ++ D G+TA H AA GH E ++
Sbjct: 98 ADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVK 157
Query: 71 VMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQG 130
++++ G ++ A D A+H AA H E ++ L+ D T LH AA+ G
Sbjct: 158 LLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSG 217
Query: 131 CLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTAL- 189
+ V+ L + +N + GN PL +A NG + + L+D GA VN +N+ G T L
Sbjct: 218 MISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLH 277
Query: 190 MLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKL 227
A + +E L+ GAD+N+ G LH + L
Sbjct: 278 FAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTAL 315
Score = 99.0 bits (245), Expect = 2e-20
Identities = 65/220 (29%), Positives = 100/220 (45%), Gaps = 1/220 (0%)
Query: 12 DTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGH-VECLR 70
D NE N + L + V + L GA + + +G T H AAA H CL
Sbjct: 231 DMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLE 290
Query: 71 VMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQG 130
+++ +G DV + G + LH+ A + + ++QS + D +G T LH AA G
Sbjct: 291 LLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYG 350
Query: 131 CLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALM 190
+ L + + + G PL LA +G S+ C LL G D+++ + GRT L
Sbjct: 351 HELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLH 410
Query: 191 LACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSEN 230
A G+ + L+ GAD N D G + LHY+ + N
Sbjct: 411 AAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCN 450
Score = 96.7 bits (239), Expect = 9e-20
Identities = 66/244 (27%), Positives = 109/244 (44%), Gaps = 6/244 (2%)
Query: 9 RKSDTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVEC 68
R ++ N ++K D R + +V LL GA T D + T H AA+ G +
Sbjct: 162 RGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISV 221
Query: 69 LRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAA 128
++ ++ GVD+ + G++ LH+A N + +L+ + G T LH+AAA
Sbjct: 222 VKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAA 281
Query: 129 --QGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGR 186
G L +++L + + +N+K DG PL + +G ++ GA ++ +K+G
Sbjct: 282 STHGAL-CLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGN 340
Query: 187 TALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQDAD 246
T L +A G + LI GAD G LH + LS G +S D
Sbjct: 341 TPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALS---GFSDCCRKLLSSGFD 397
Query: 247 LKTP 250
+ TP
Sbjct: 398 IDTP 401
Score = 95.1 bits (235), Expect = 3e-19
Identities = 73/275 (26%), Positives = 119/275 (43%), Gaps = 22/275 (8%)
Query: 26 AVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVD---VTAQ 82
A G E V L+ + + K +T H AA GH ECLR++I + V Q
Sbjct: 590 AAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQ 649
Query: 83 DTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHK 142
D G + L L+ N H +C+ LL ++ D G+TALH A G + V L +H
Sbjct: 650 DGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHG 709
Query: 143 SPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSR----NKSGRTALMLACEIGSS 198
+ L+D G P+ L+ GH + LL A +++ + G TAL AC G
Sbjct: 710 AKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHE 769
Query: 199 NAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKI------SQDADLKTPTK 252
VE L+++ + ++ LH + +++N G +L+ + + D+ +TP
Sbjct: 770 TCVELLLEQEV-FQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLH 828
Query: 253 PKQLSD--------VSSPRSITSTPLSGKESVFFA 279
+D +S + S +GK + A
Sbjct: 829 AAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMA 863
Score = 89.4 bits (220), Expect = 1e-17
Identities = 59/195 (30%), Positives = 85/195 (43%)
Query: 38 LLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNS 97
LL GA +GKT H+ A G + +I G + +D G++ LH+AA+
Sbjct: 291 LLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYG 350
Query: 98 HHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLL 157
H I L+ S G LH AA G + L I+ D G L
Sbjct: 351 HELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLH 410
Query: 158 LAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSL 217
A G+ E + LL+ GAD N ++K GR+ L A + + AL+ GA +N +D
Sbjct: 411 AAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDER 470
Query: 218 GYNALHYSKLSENAG 232
G LHY+ S+ G
Sbjct: 471 GCTPLHYAATSDTDG 485
Score = 85.1 bits (209), Expect = 3e-16
Identities = 69/239 (28%), Positives = 123/239 (51%), Gaps = 14/239 (5%)
Query: 8 FRKSDTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVE 67
F+K++ N ++ ++ E G AE + LG +AT DS+G+T H AA HVE
Sbjct: 781 FQKTEGNAFSPLHCAVINDNE-GAAEMLIDTLGASIVNAT--DSKGRTPLHAAAFTDHVE 837
Query: 68 CLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESV-DSSGKTALHYA 126
CL+++++H V + D+TG + L +AA+N + L+ S ++ D+S TALH A
Sbjct: 838 CLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLA 897
Query: 127 AAQGCLQAVQILCE---HKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNK 183
++G + ++ E ++ IN + PL +A +NG + + LL GA V + ++
Sbjct: 898 CSKGHETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDE 957
Query: 184 SGRTALMLACEIGSSNA-----VEALIKKGADLNLVDSLGYNALH-YSKLSENAGIQSL 236
+G T LAC A + A + + + + SL +NA++ Y+ S+ ++L
Sbjct: 958 NGYTP-ALACAPNKDVADCLALILATMMPVSSSSPLSSLTFNAINRYTNTSKTVSFEAL 1015
>gi|96975023 ankyrin repeat and death domain containing 1A [Homo
sapiens]
Length = 522
Score = 113 bits (282), Expect = 1e-24
Identities = 67/214 (31%), Positives = 110/214 (51%), Gaps = 1/214 (0%)
Query: 25 QAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDT 84
+A E+G + + L+G G D EG TA HLAA +GH+ L+ ++ G+D+ Q+
Sbjct: 165 RAAEHGQLDALDFLVGS-GCDHNVKDKEGNTALHLAAGRGHMAVLQRLVDIGLDLEEQNA 223
Query: 85 TGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSP 144
G +ALH AA SH +C++ LL++ ++ + LHYAA G ++L
Sbjct: 224 EGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGC 283
Query: 145 INLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEAL 204
N+ D G PL LAV++ + L++ +DVN+ + +T L LA E + + L
Sbjct: 284 ANVVDHQGASPLHLAVRHNFPALVRLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADML 343
Query: 205 IKKGADLNLVDSLGYNALHYSKLSENAGIQSLLL 238
+ G DLNL D G AL + S + + +++
Sbjct: 344 LIAGVDLNLRDKQGKTALAVAVRSNHVSLVDMII 377
Score = 95.1 bits (235), Expect = 3e-19
Identities = 56/188 (29%), Positives = 92/188 (48%), Gaps = 2/188 (1%)
Query: 53 GKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQ--SKC 110
G A L+A GH+ L++++ G + + G + LH AA+ H + +++
Sbjct: 91 GMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDLEDV 150
Query: 111 PAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHF 170
+ VD G+TA H AA G L A+ L N+KD +GN L LA GH +
Sbjct: 151 ALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQR 210
Query: 171 LLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSEN 230
L+D G D+ +N G TAL A + V+ L++ G+ +N + + LHY+ LS +
Sbjct: 211 LVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYAALSGS 270
Query: 231 AGIQSLLL 238
+ +L+
Sbjct: 271 EDVSRVLI 278
Score = 85.5 bits (210), Expect = 2e-16
Identities = 63/224 (28%), Positives = 98/224 (43%), Gaps = 5/224 (2%)
Query: 34 KVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQ--DTTGHSALH 91
++ +L GA +G T H AA KGHV L ++ DV D G +A H
Sbjct: 105 RILQILVNSGAKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFH 164
Query: 92 LAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLD 151
AA++ + + L+ S C D G TALH AA +G + +Q L + + ++ +
Sbjct: 165 RAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVDIGLDLEEQNAE 224
Query: 152 GNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADL 211
G L A H + LL G+ VN+ + + L A GS + LI G
Sbjct: 225 GLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCA 284
Query: 212 NLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKTPTKPKQ 255
N+VD G + LH L+ +L+ I+ D+D+ +Q
Sbjct: 285 NVVDHQGASPLH---LAVRHNFPALVRLLINSDSDVNAVDNRQQ 325
Score = 62.0 bits (149), Expect = 3e-09
Identities = 43/146 (29%), Positives = 75/146 (51%), Gaps = 12/146 (8%)
Query: 90 LHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKD 149
LH AA+ ++ +++L+ + + + G+ ALH+AA G QAV++L EH++ ++ +D
Sbjct: 19 LHEAARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVDEED 78
Query: 150 LDGNI----------PLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSN 199
G + LLL+ GH I L++ GA ++ +K G T L A + G
Sbjct: 79 AVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVP 138
Query: 200 AVEALIKKGADLNL--VDSLGYNALH 223
+ +++ D+ L VD LG A H
Sbjct: 139 VLAFIMEDLEDVALDHVDKLGRTAFH 164
Score = 33.9 bits (76), Expect = 0.74
Identities = 15/59 (25%), Positives = 33/59 (55%)
Query: 50 DSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQS 108
D+ +T HLAA + +++ GVD+ +D G +AL +A +++H + ++++
Sbjct: 321 DNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSLVDMIIKA 379
>gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens]
Length = 1417
Score = 112 bits (280), Expect = 2e-24
Identities = 147/675 (21%), Positives = 297/675 (44%), Gaps = 133/675 (19%)
Query: 332 LHNKELQDKLQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSL 391
L K+ Q K Q K+ + D+ +H D + K GE + K + + +L
Sbjct: 777 LEKKDQQFKEQEKTMSMLQQDIICKQHHLESLDRLLTESK-GEMKKENMKKDEA--LKAL 833
Query: 392 GKSTTDNDVRIQQLQEILQ----DLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISE 447
++ ++++QL L+ +L L E +++ + +L+ + E+ CL +
Sbjct: 834 QNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIK 893
Query: 448 NSSDLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLK 507
N S L+ET S+ ++ L Q+QM + E++ N E++++ L+
Sbjct: 894 NHS-----LQET-SEQNVILQHTLQQQQQM----LQQETIRNGELEDTQTKLEKQVSKLE 943
Query: 508 QDLQNALEESERNKEKVRELEEKL--------VEREK-----GTV--IKPPVEEYEEM-- 550
Q+LQ ++ E + EK+R++EEK ++R+K GT +K +++Y+E
Sbjct: 944 QELQ---KQRESSAEKLRKMEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQYKEELS 1000
Query: 551 ---------------KSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEAS 595
K+ + S ++ + + EK A +E+ KL+ + ++++T EA
Sbjct: 1001 KMEKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTETELT-EAL 1059
Query: 596 DEAEDMKEAMNRMIDELN---KQVSELSQLYKEAQAELEDYRKRKSLEDVTAEYIHKAEH 652
+ E ++ + EL +Q+ EL + ++AQ LE+ K +++D+TAE
Sbjct: 1060 QKREVLETELQNAHGELKSTLRQLQELRDVLQKAQLSLEE--KYTTIKDLTAE------- 1110
Query: 653 EKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQ----KENSVSITEHLQVI 708
L E K + EL ++ Q + + K+ + +T HL +
Sbjct: 1111 -----------------LRECKMEIEDKKQELLEMDQALKERNWELKQRAAQVT-HLDM- 1151
Query: 709 TTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLE 768
T+R EME+KI L+ L E+E+ + KQ+ S +KLQ++
Sbjct: 1152 -TIREHRGEMEQKIIKLEGTLEKSELELKECNKQI-------------ESLNDKLQNA-- 1195
Query: 769 SEVSVLASKLKESVKEKEKV----HSEVVQIRSEVSQVKREKENIQTLLKSKEQEV-NEL 823
KE ++EKE + E+ Q++ E+ + ++ + +++++K +EQ + +
Sbjct: 1196 ----------KEQLREKEFIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQYIATQY 1245
Query: 824 LQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLS------- 876
+ QE ++ S ++L E + +++ + +E+ +L L + QLS
Sbjct: 1246 KEAIDLGQELRLTREQVQNSHTELAEARHQQV-QAQREIERLSSELEDMKQLSKEKDAHG 1304
Query: 877 ----YSTSSSKRQSQQLEA-LQQQVKQLQNQLAECKK-QHQEVISVYRMHLLYAVQGQMD 930
+SK + LEA +Q ++K+L ++ K+ H E+IS H + +
Sbjct: 1305 NHLAEELGASKVREAHLEARMQAEIKKLSAEVESLKEAYHMEMISHQENHAKWKISADSQ 1364
Query: 931 EDVQKVLKQILTMCK 945
+ + L + L K
Sbjct: 1365 KSSVQQLNEQLEKAK 1379
Score = 77.4 bits (189), Expect = 6e-14
Identities = 129/585 (22%), Positives = 263/585 (44%), Gaps = 72/585 (12%)
Query: 387 LIHSLGKSTTDNDVRIQQLQEILQDLQK-RLESSEAERKQLQVELQSRRAELVCLNNTEI 445
L L K N + Q ++ + E +++ K +E ++A V + +I
Sbjct: 234 LREKLNKLRQQNACLVTQNHSLMTKFESIHFELTQSRAKVSMLESAQQQAASVPILEEQI 293
Query: 446 SENSSDLSQK---LKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEE 502
+++S + L+E ++K E++ K V+ ++ L+ ++EE
Sbjct: 294 INLEAEVSAQDKVLREAENKLEQSQKMVIEKEQS-------------------LQESKEE 334
Query: 503 INVLKQDLQNALEESERNKEKVRELEEKLVEREKGTVI----KPPVEEYEEMKSSYCSVI 558
LK DL LE++++ K R+ E L E+ + K V E E + ++
Sbjct: 335 CIKLKVDL---LEQTKQGKRAERQRNEALYNAEELSKAFQQYKKKVAEKLEKVQAEEEIL 391
Query: 559 E----NMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNK 614
E N KE L E+ + E+ LK+ L+ Q+ +E ++ E ++ M E+
Sbjct: 392 ERNLTNCEKENKRLQERCGLYKSELEILKEKLR-QLKEENNNGKEKLR-IMAVKNSEVMA 449
Query: 615 QVSELSQLYKEAQAELED----YRKRKSLEDVTAEYIHK--AEHEKLMQLTNVSRAKAED 668
Q++E Q + ++ELE+ R + SL + E + A++E+L ++ + + E
Sbjct: 450 QLTESRQSILKLESELENKDEILRDKFSLMNENRELKVRVAAQNERL----DLCQQEIES 505
Query: 669 ALSEMKSQYSKVLNELTQLKQLVDAQKENS-VSITEHLQVITTLRTAAKEMEEKISNLKE 727
+ E++S K++++L ++L + S ++ + + IS L+
Sbjct: 506 SRVELRS-LEKIISQLPLKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISELRI 564
Query: 728 HLASKEVEVAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLESE-VSVLASKLKESVKEKE 786
LA KE E+ KL L + + + S SSLE+E V + ++ ESVK++
Sbjct: 565 KLAIKEAEIQKLHANLTANQLSQSLITCNDSQESSKLSSLETEPVKLGGHQVAESVKDQN 624
Query: 787 KVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEVNEL-------LQKFQQAQEELAEMKR 839
+ H+ Q E ++ E ++T L E E ++L +FQ QEEL E
Sbjct: 625 Q-HTMNKQYEKERQRLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELLEK-- 681
Query: 840 YAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQLEALQQQVKQL 899
A +SSKLE + KK +++ +L+E + ++YS+ ++K + E +++ K +
Sbjct: 682 -ASNSSKLESEMTKKCSQLLTLEKQLEEKI-----VAYSSIAAKNAELEQELMEKNEK-I 734
Query: 900 QNQLAECKKQHQEVISVY----RMHLLYAVQGQMDEDVQKVLKQI 940
++ +H+++ + ++HL +M++ ++++ Q+
Sbjct: 735 RSLETNINTEHEKICLAFEKAKKIHL--EQHKEMEKQIERLEAQL 777
Score = 54.3 bits (129), Expect = 5e-07
Identities = 109/500 (21%), Positives = 198/500 (39%), Gaps = 100/500 (20%)
Query: 494 HELRVTEEEINVLKQDLQNALEESERNKEKVRELEEKLV----EREKGTVIKPPVEEYEE 549
HEL++TE + L ++L + + EKL+ G + P YE
Sbjct: 145 HELKITEWSLQSLGEELSSVSPSENSDYAPNPSRSEKLILDVQPSHPGLLNYSP---YEN 201
Query: 550 MKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKDTL----------------------- 586
+ S + K + +F +EI L++ L
Sbjct: 202 VCKISGSSTDFQKKPRDKMFSSSAPVDQEIKSLREKLNKLRQQNACLVTQNHSLMTKFES 261
Query: 587 ----------KSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELED---- 632
K M + A +A + + I L +VS ++ +EA+ +LE
Sbjct: 262 IHFELTQSRAKVSMLESAQQQAASV-PILEEQIINLEAEVSAQDKVLREAENKLEQSQKM 320
Query: 633 -YRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAE--------DALSEMKSQYSKVLNE 683
K +SL++ E I K + + L Q RA+ + + LS+ QY K + E
Sbjct: 321 VIEKEQSLQESKEECI-KLKVDLLEQTKQGKRAERQRNEALYNAEELSKAFQQYKKKVAE 379
Query: 684 LTQLKQ---------LVDAQKENSVSITE----HLQVITTLRTAAKEMEEKISNLKEHLA 730
+ Q L + +KEN + E + + L+ ++++E+ +N KE L
Sbjct: 380 KLEKVQAEEEILERNLTNCEKENK-RLQERCGLYKSELEILKEKLRQLKEENNNGKEKLR 438
Query: 731 SKEVEVAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHS 790
V+ +++ QL E R S KL+S LE++ +L K + E ++
Sbjct: 439 IMAVKNSEVMAQLTES----------RQSILKLESELENKDEILRDKF-SLMNENRELKV 487
Query: 791 EVVQIRSEVSQVKREKENIQTLLKSKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEED 850
V + ++E E+ + L+S E+ +++L K ++ + + +Y SS +ED
Sbjct: 488 RVAAQNERLDLCQQEIESSRVELRSLEKIISQLPLK-RELFGFKSYLSKYQMSSFSNKED 546
Query: 851 KDKKINEMSK---------------EVTKLKEAL--NSLSQLSYSTSSSKRQSQQLEALQ 893
+ E +K E+ KL L N LSQ S T + ++S +L +L+
Sbjct: 547 RCIGCCEANKLVISELRIKLAIKEAEIQKLHANLTANQLSQ-SLITCNDSQESSKLSSLE 605
Query: 894 -QQVKQLQNQLAECKKQHQE 912
+ VK +Q+AE K +
Sbjct: 606 TEPVKLGGHQVAESVKDQNQ 625
>gi|116875852 HECT domain and ankyrin repeat containing, E3
ubiquitin protein ligase 1 [Homo sapiens]
Length = 909
Score = 112 bits (279), Expect = 2e-24
Identities = 57/156 (36%), Positives = 87/156 (55%)
Query: 54 KTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAE 113
++ H+AA G VECL +++ G + QD +G + LHLAA+N +C+ KLL+
Sbjct: 66 RSLLHIAANCGSVECLVLLLKKGANPNYQDISGCTPLHLAARNGQKKCMSKLLEYSADVN 125
Query: 114 SVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLD 173
++ G TA+H+ A G + + L +H S ++++D G L +A QNGH LLD
Sbjct: 126 ICNNEGLTAIHWLAVNGRTELLHDLVQHVSDVDVEDAMGQTALHVACQNGHKTTVQCLLD 185
Query: 174 HGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGA 209
GAD+N N SG T L AC G + + L+ +GA
Sbjct: 186 SGADINRPNVSGATPLYFACSHGQRDTAQILLLRGA 221
Score = 87.8 bits (216), Expect = 4e-17
Identities = 59/184 (32%), Positives = 85/184 (46%), Gaps = 1/184 (0%)
Query: 23 LLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQ 82
LL N + + LL KKGA+ D G T HLAA G +C+ ++ + DV
Sbjct: 68 LLHIAANCGSVECLVLLLKKGANPNYQDISGCTPLHLAARNGQKKCMSKLLEYSADVNIC 127
Query: 83 DTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHK 142
+ G +A+H A N E + L+Q + D+ G+TALH A G VQ L +
Sbjct: 128 NNEGLTAIHWLAVNGRTELLHDLVQHVSDVDVEDAMGQTALHVACQNGHKTTVQCLLDSG 187
Query: 143 SPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVE 202
+ IN ++ G PL A +G + LL GA +K+G T L L + G E
Sbjct: 188 ADINRPNVSGATPLYFACSHGQRDTAQILLLRGAKY-LPDKNGVTPLDLCVQGGYGETCE 246
Query: 203 ALIK 206
LI+
Sbjct: 247 VLIQ 250
Score = 80.1 bits (196), Expect = 9e-15
Identities = 50/149 (33%), Positives = 73/149 (48%), Gaps = 2/149 (1%)
Query: 26 AVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTT 85
A NG + ++ LL + A ++EG TA H A G E L ++ H DV +D
Sbjct: 105 AARNGQKKCMSKLL-EYSADVNICNNEGLTAIHWLAVNGRTELLHDLVQHVSDVDVEDAM 163
Query: 86 GHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPI 145
G +ALH+A +N H ++ LL S + SG T L++A + G QIL +
Sbjct: 164 GQTALHVACQNGHKTTVQCLLDSGADINRPNVSGATPLYFACSHGQRDTAQILLLRGAKY 223
Query: 146 NLKDLDGNIPLLLAVQNGHSEICHFLLDH 174
L D +G PL L VQ G+ E C L+ +
Sbjct: 224 -LPDKNGVTPLDLCVQGGYGETCEVLIQY 251
Score = 79.7 bits (195), Expect = 1e-14
Identities = 45/138 (32%), Positives = 73/138 (52%)
Query: 88 SALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINL 147
S LH+AA EC+ LL+ D SG T LH AA G + + L E+ + +N+
Sbjct: 67 SLLHIAANCGSVECLVLLLKKGANPNYQDISGCTPLHLAARNGQKKCMSKLLEYSADVNI 126
Query: 148 KDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKK 207
+ +G + NG +E+ H L+ H +DV+ + G+TAL +AC+ G V+ L+
Sbjct: 127 CNNEGLTAIHWLAVNGRTELLHDLVQHVSDVDVEDAMGQTALHVACQNGHKTTVQCLLDS 186
Query: 208 GADLNLVDSLGYNALHYS 225
GAD+N + G L+++
Sbjct: 187 GADINRPNVSGATPLYFA 204
Score = 61.2 bits (147), Expect = 4e-09
Identities = 37/131 (28%), Positives = 69/131 (52%), Gaps = 3/131 (2%)
Query: 120 KTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVN 179
++ LH AA G ++ + +L + + N +D+ G PL LA +NG + LL++ ADVN
Sbjct: 66 RSLLHIAANCGSVECLVLLLKKGANPNYQDISGCTPLHLAARNGQKKCMSKLLEYSADVN 125
Query: 180 SRNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLS 239
N G TA+ G + + L++ +D+++ D++G ALH ++ G ++ +
Sbjct: 126 ICNNEGLTAIHWLAVNGRTELLHDLVQHVSDVDVEDAMGQTALH---VACQNGHKTTVQC 182
Query: 240 KISQDADLKTP 250
+ AD+ P
Sbjct: 183 LLDSGADINRP 193
>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
sapiens]
Length = 765
Score = 111 bits (277), Expect = 4e-24
Identities = 67/200 (33%), Positives = 100/200 (50%)
Query: 24 LQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQD 83
L + E VA LL + A H++EGKT H+AA GHV ++++ + G ++ AQ
Sbjct: 465 LHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQ 524
Query: 84 TTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKS 143
+ LHLA + I+ LL+S +++D SG LH AAA+G ++L + +
Sbjct: 525 RNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGA 584
Query: 144 PINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEA 203
+ L G PL LA GH EI H L + A++ + T L LA G V A
Sbjct: 585 SLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSA 644
Query: 204 LIKKGADLNLVDSLGYNALH 223
L++ GAD N + G+ LH
Sbjct: 645 LLQCGADPNAAEQSGWTPLH 664
Score = 93.6 bits (231), Expect = 8e-19
Identities = 65/225 (28%), Positives = 101/225 (44%), Gaps = 4/225 (1%)
Query: 27 VENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTG 86
V G E+V LL + + G T +AA + +++ HG D D G
Sbjct: 370 VAQGSVEQVRLLLAHE-VDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDG 428
Query: 87 HSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPIN 146
+ LH AA+N R LL ++ + G T LH AA ++L ++ N
Sbjct: 429 WAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPN 488
Query: 147 LKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIK 206
L + +G PL +A GH + L GA+++++ ++ RT L LA E G A++ L+K
Sbjct: 489 LHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLK 548
Query: 207 KGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKTPT 251
GA + +D GY LH + I +LL A L+ PT
Sbjct: 549 SGAVPDALDQSGYGPLHTAAARGKYLICKMLL---RYGASLELPT 590
Score = 91.7 bits (226), Expect = 3e-18
Identities = 59/192 (30%), Positives = 93/192 (48%), Gaps = 1/192 (0%)
Query: 55 TAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAES 114
T H A+G VE +R+++ H VDV Q +G++ L +AA++ + LL A
Sbjct: 364 TPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANR 423
Query: 115 VDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDH 174
VD G LH+AA G ++L +H + ++ ++ +G PL LA QN + L+
Sbjct: 424 VDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSR 483
Query: 175 GADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYS-KLSENAGI 233
AD N G+T L +A G + V+ L +GA+L+ LH + + + I
Sbjct: 484 QADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAI 543
Query: 234 QSLLLSKISQDA 245
Q LL S DA
Sbjct: 544 QHLLKSGAVPDA 555
Score = 91.7 bits (226), Expect = 3e-18
Identities = 66/215 (30%), Positives = 101/215 (46%), Gaps = 1/215 (0%)
Query: 23 LLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQ 82
LL A ++ + A LL GA A + D +G H AA G R+++ HG V AQ
Sbjct: 399 LLIAAQDQQPDLCALLLAH-GADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQ 457
Query: 83 DTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHK 142
+ G + LHLAA+N+ R L+ + ++ GKT LH AA G + V++L
Sbjct: 458 EREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQG 517
Query: 143 SPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVE 202
+ ++ + + PL LAV+ G LL GA ++ ++SG L A G +
Sbjct: 518 AELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICK 577
Query: 203 ALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLL 237
L++ GA L L G+ LH + + I LL
Sbjct: 578 MLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLL 612
Score = 52.0 bits (123), Expect = 3e-06
Identities = 36/138 (26%), Positives = 64/138 (46%)
Query: 34 KVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLA 93
++ LL + A+ + T HLAA G + ++ G D A + +G + LHLA
Sbjct: 607 EIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLA 666
Query: 94 AKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGN 153
+ S + LL+ + + G T H AA +G +++L E + ++++D
Sbjct: 667 VQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSC 726
Query: 154 IPLLLAVQNGHSEICHFL 171
PL LA+++ I FL
Sbjct: 727 TPLQLALRSRKQGIMSFL 744
Score = 37.7 bits (86), Expect = 0.051
Identities = 33/130 (25%), Positives = 57/130 (43%), Gaps = 3/130 (2%)
Query: 26 AVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTT 85
A +G+ E V S L + GA + G T HLA + + ++ H +V A++
Sbjct: 633 AARHGE-EAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKV 691
Query: 86 GHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPI 145
G + HLAA + ++ L+++ + D T L A + Q + E K P
Sbjct: 692 GWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQ-LALRSRKQGIMSFLEGKEP- 749
Query: 146 NLKDLDGNIP 155
++ L G+ P
Sbjct: 750 SVATLGGSKP 759
>gi|239755011 PREDICTED: ankyrin repeat domain 18B [Homo sapiens]
Length = 1363
Score = 111 bits (277), Expect = 4e-24
Identities = 202/939 (21%), Positives = 377/939 (40%), Gaps = 141/939 (15%)
Query: 22 RLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVE-------------- 67
++ +A GDA +V L ++ D + +T HLA A G V+
Sbjct: 136 KIHRAAIKGDAAEVEHCLTRRFRDLDVRDKKDRTVLHLACAHGRVQVVTLLLDRKCQINI 195
Query: 68 -------------------CLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQS 108
C +++ G + +D G++ALH A N +LL
Sbjct: 196 CDRLNRTPLMKAVHCQEEACAIILLKRGANPNIKDIYGNTALHYAVYNEGTSLAERLLSH 255
Query: 109 KCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEIC 168
E+++ G T L +A V+ L ++++ I+ D L+LAVQ+ S I
Sbjct: 256 HANIEALNKEGNTPLLFAINSRRQHMVEFLLKNQANIHAVDNFKRTALILAVQHNLSSIV 315
Query: 169 HFLLDHGADVNSRNKSGRTA--LMLACEIGS--SNAVEALIKKGADLNLVDSLGYNALHY 224
LL ++S++ G+TA C++ S +E K + D+ A+
Sbjct: 316 TLLLQQNIHISSQDMFGQTAEDYAFCCDLRSIQQQILEHKNKMLKNHLRNDNQETAAMKP 375
Query: 225 SKLSENAGIQSLLLSKISQDAD--LKTPTKPKQ--LSDVSSPRSITSTPLSGKESVFFAE 280
L + + L K A+ LK ++ KQ L + + S K+ F
Sbjct: 376 ENLKKRKKRKKLKKRKEGAKAEHNLKVASEEKQERLERSENKQPQDSQSYGKKKDEMFGN 435
Query: 281 PPFKAEISSIRENKDRLSDSTTGAD--------SLLDISSEADQQDLLS--LLQAKVA-- 328
K +I+ ++E + + + + S+ +I++ ++ L+ ++ KVA
Sbjct: 436 FMLKRDIAMLKEELYAIKNDSLRKEKKYIQEIKSITEINANFEKSVRLNEEMITKKVAQY 495
Query: 329 -----SLTLHNKELQDKLQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSS 383
L N L KL+ + + + +S HS +L ++ + E + K
Sbjct: 496 SQQLNDLKAENARLNSKLEKEKHNKERLEAEVESLHS---NLATAINEYNEIL--ERKDL 550
Query: 384 PSVLIHSLGKSTTDN-DVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNN 442
VL + S + I QL + + L +++ + + L+ +L+ R L
Sbjct: 551 ELVLWRADDVSRHETMGSNISQLTDKNELLTEQVHKARVKFNTLKGKLRETRD---ALRE 607
Query: 443 TEISENSSDLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMD---NYSHFHELRVT 499
++ S L LK+ Q + +E KQM + ES S +R
Sbjct: 608 KTLALESVQLD--LKQAQHRIKE--------MKQMHPNGEAKESQSIGKQNSSEERIRQR 657
Query: 500 EEEINVLKQDLQNALEESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIE 559
E E +L++ L++A +E + NKE V + +E K +++ E +E+ + Y
Sbjct: 658 ELENLLLERQLEDARKEGD-NKEIVINIHRDCLENGKEDLLE---ERNKELMNEY----- 708
Query: 560 NMNKEKAFLFEKYQEAQEEIMK-----LKDTLKSQMTQEASDEAEDMKEAMNRMIDELNK 614
N KEK +EK + +E I++ L D LK E+ E + +DE
Sbjct: 709 NYLKEKLLQYEKEKAEREVIVREFQEELVDHLKKFSMSESPLEG---TSHCHINLDETWT 765
Query: 615 QVSELSQLYKEAQAELEDYRK---RKSLEDVTAEYIHKAEHE---------KLMQLT--- 659
+L Q+ + + + E++RK SL + TA+ I K E K +++T
Sbjct: 766 SKKKLFQVEIQPEEKHEEFRKVFELISLLNYTADQIRKKNRELEEEATGYKKCLEMTINM 825
Query: 660 ---------------NVSRAKAEDALSEMKSQYSKVLNELTQL-KQLVDAQKENSVSITE 703
N + K + ++K ++ ++ E + + V+ K+N V E
Sbjct: 826 LNAFANEDFSCHGDLNTDQLKMDILFKKLKQKFDDLMAEKEAVSSKCVNLAKDNEVLHQE 885
Query: 704 HLQV------ITTLRTAAKEMEEKISNLKEHLASKEVEVAKLE--KQLLEEKAAMTDAMV 755
L + L K +EEK+ NLK H+ VE+ K++ K L+E+A +
Sbjct: 886 LLSMGKVQEKCEKLEKDKKMLEEKVLNLKTHMEKDMVELGKVQEYKSELDERAMQAIEKL 945
Query: 756 PRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKS 815
+K Q+ E ++ L S+K+KE +V + S++K E++ T L+
Sbjct: 946 EEIHLQK-QAEYEKQLEQLNKDNTASLKKKELTLKDV---ECKFSKMKTAYEDVTTELEE 1001
Query: 816 KEQEVNELLQKFQQAQEELAEM-KRYAESSSKLEEDKDK 853
++ L+ E++ + K+ A S+KL +K++
Sbjct: 1002 YKEAFAVALKANSSMSEKITKSDKKIAVISTKLFMEKER 1040
Score = 100 bits (249), Expect = 6e-21
Identities = 194/914 (21%), Positives = 362/914 (39%), Gaps = 146/914 (15%)
Query: 58 HLAAAKGHVECLRVMITHGV-DVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVD 116
H AA KG + +T D+ +D + LHLA + + + LL KC D
Sbjct: 138 HRAAIKGDAAEVEHCLTRRFRDLDVRDKKDRTVLHLACAHGRVQVVTLLLDRKCQINICD 197
Query: 117 SSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGA 176
+T L A IL + + N+KD+ GN L AV N + + LL H A
Sbjct: 198 RLNRTPLMKAVHCQEEACAIILLKRGANPNIKDIYGNTALHYAVYNEGTSLAERLLSHHA 257
Query: 177 DVNSRNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSL 236
++ + NK G T L+ A + VE L+K A+++ VD+ AL + + I +L
Sbjct: 258 NIEALNKEGNTPLLFAINSRRQHMVEFLLKNQANIHAVDNFKRTALILAVQHNLSSIVTL 317
Query: 237 LLSKISQDADLKTPTKPKQLSDVSSPRSITSTPLSGKESVFFAEPPFKAEISSIRENKDR 296
LL + I+S + G+ + +A F ++ SI++
Sbjct: 318 LLQQNIH---------------------ISSQDMFGQTAEDYA---FCCDLRSIQQQ--- 350
Query: 297 LSDSTTGADSLLDISSEADQQDLLSLLQAKVASLTLHNKELQDKLQAKSPKE---AEADL 353
+L+ ++ + L + Q A + K+ + + + K KE AE +L
Sbjct: 351 ----------ILEHKNKMLKNHLRNDNQETAAMKPENLKKRKKRKKLKKRKEGAKAEHNL 400
Query: 354 SFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDVRIQQLQEILQDLQ 413
S + L + P DS+S G D+ + L+E L ++
Sbjct: 401 KVASEEKQER-----LERSENKQPQDSQSYGKKKDEMFGNFMLKRDIAM--LKEELYAIK 453
Query: 414 KRLESSEAERKQLQ-----VELQSRRAELVCLNNTEISENSSDLSQKLKETQSKYEEAMK 468
+S E+K +Q E+ + + V LN I++ + SQ+L + +++ +
Sbjct: 454 N--DSLRKEKKYIQEIKSITEINANFEKSVRLNEEMITKKVAQYSQQLNDLKAE-NARLN 510
Query: 469 EVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESERNKEKVRELE 528
L +K K L E E+ L +L A+ E E+ ++LE
Sbjct: 511 SKLEKEKHNKERL------------------EAEVESLHSNLATAINEYNEILER-KDLE 551
Query: 529 EKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKDTLKS 588
L + V +E M S+ I + + L E+ +A+ + LK L+
Sbjct: 552 LVLWRADD-------VSRHETMGSN----ISQLTDKNELLTEQVHKARVKFNTLKGKLRE 600
Query: 589 QMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLY-----KEAQA--------------E 629
T++A E E++ + + ++ E+ Q++ KE+Q+ E
Sbjct: 601 --TRDALREKTLALESVQLDLKQAQHRIKEMKQMHPNGEAKESQSIGKQNSSEERIRQRE 658
Query: 630 LEDYRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSK-VLNELTQLK 688
LE+ + LED E +K + N+ R E+ ++ + +K ++NE LK
Sbjct: 659 LENLLLERQLEDARKEGDNKEI------VINIHRDCLENGKEDLLEERNKELMNEYNYLK 712
Query: 689 Q-LVDAQKENSV----------SITEHLQVITTLRTAAKEMEEKISNLKEHLASK----E 733
+ L+ +KE + + +HL+ + + + NL E SK +
Sbjct: 713 EKLLQYEKEKAEREVIVREFQEELVDHLKKFSMSESPLEGTSHCHINLDETWTSKKKLFQ 772
Query: 734 VEVAKLEKQLLEEKAAMTDAMVPRSSYE--KLQSSLESEVSVLASKLKESVKEKEKVHSE 791
VE+ EK K +++ ++ + K LE E + L+ ++ +E
Sbjct: 773 VEIQPEEKHEEFRKVFELISLLNYTADQIRKKNRELEEEATGYKKCLEMTINMLNAFANE 832
Query: 792 VVQIRSEVSQ--------VKREKENIQTLLKSKEQEVNE---LLQKFQQAQEELAEMKRY 840
+++ K+ K+ L+ KE ++ L + + +EL M +
Sbjct: 833 DFSCHGDLNTDQLKMDILFKKLKQKFDDLMAEKEAVSSKCVNLAKDNEVLHQELLSMGKV 892
Query: 841 AESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQL-SYSTSSSKRQSQQLEALQQQVKQL 899
E KLE+DK ++ T +++ + L ++ Y + +R Q +E L++ Q
Sbjct: 893 QEKCEKLEKDKKMLEEKVLNLKTHMEKDMVELGKVQEYKSELDERAMQAIEKLEEIHLQK 952
Query: 900 QNQLAECKKQHQEV 913
Q AE +KQ +++
Sbjct: 953 Q---AEYEKQLEQL 963
>gi|239749555 PREDICTED: ankyrin repeat domain 18B [Homo sapiens]
Length = 1366
Score = 111 bits (277), Expect = 4e-24
Identities = 202/939 (21%), Positives = 377/939 (40%), Gaps = 141/939 (15%)
Query: 22 RLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVE-------------- 67
++ +A GDA +V L ++ D + +T HLA A G V+
Sbjct: 165 KIHRAAIKGDAAEVEHCLTRRFRDLDVRDKKDRTVLHLACAHGRVQVVTLLLDRKCQINI 224
Query: 68 -------------------CLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQS 108
C +++ G + +D G++ALH A N +LL
Sbjct: 225 CDRLNRTPLMKAVHCQEEACAIILLKRGANPNIKDIYGNTALHYAVYNEGTSLAERLLSH 284
Query: 109 KCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEIC 168
E+++ G T L +A V+ L ++++ I+ D L+LAVQ+ S I
Sbjct: 285 HANIEALNKEGNTPLLFAINSRRQHMVEFLLKNQANIHAVDNFKRTALILAVQHNLSSIV 344
Query: 169 HFLLDHGADVNSRNKSGRTA--LMLACEIGS--SNAVEALIKKGADLNLVDSLGYNALHY 224
LL ++S++ G+TA C++ S +E K + D+ A+
Sbjct: 345 TLLLQQNIHISSQDMFGQTAEDYAFCCDLRSIQQQILEHKNKMLKNHLRNDNQETAAMKP 404
Query: 225 SKLSENAGIQSLLLSKISQDAD--LKTPTKPKQ--LSDVSSPRSITSTPLSGKESVFFAE 280
L + + L K A+ LK ++ KQ L + + S K+ F
Sbjct: 405 ENLKKRKKRKKLKKRKEGAKAEHNLKVASEEKQERLERSENKQPQDSQSYGKKKDEMFGN 464
Query: 281 PPFKAEISSIRENKDRLSDSTTGAD--------SLLDISSEADQQDLLS--LLQAKVA-- 328
K +I+ ++E + + + + S+ +I++ ++ L+ ++ KVA
Sbjct: 465 FMLKRDIAMLKEELYAIKNDSLRKEKKYIQEIKSITEINANFEKSVRLNEEMITKKVAQY 524
Query: 329 -----SLTLHNKELQDKLQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSS 383
L N L KL+ + + + +S HS +L ++ + E + K
Sbjct: 525 SQQLNDLKAENARLNSKLEKEKHNKERLEAEVESLHS---NLATAINEYNEIL--ERKDL 579
Query: 384 PSVLIHSLGKSTTDN-DVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNN 442
VL + S + I QL + + L +++ + + L+ +L+ R L
Sbjct: 580 ELVLWRADDVSRHETMGSNISQLTDKNELLTEQVHKARVKFNTLKGKLRETRD---ALRE 636
Query: 443 TEISENSSDLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMD---NYSHFHELRVT 499
++ S L LK+ Q + +E KQM + ES S +R
Sbjct: 637 KTLALESVQLD--LKQAQHRIKE--------MKQMHPNGEAKESQSIGKQNSSEERIRQR 686
Query: 500 EEEINVLKQDLQNALEESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIE 559
E E +L++ L++A +E + NKE V + +E K +++ E +E+ + Y
Sbjct: 687 ELENLLLERQLEDARKEGD-NKEIVINIHRDCLENGKEDLLE---ERNKELMNEY----- 737
Query: 560 NMNKEKAFLFEKYQEAQEEIMK-----LKDTLKSQMTQEASDEAEDMKEAMNRMIDELNK 614
N KEK +EK + +E I++ L D LK E+ E + +DE
Sbjct: 738 NYLKEKLLQYEKEKAEREVIVREFQEELVDHLKKFSMSESPLEG---TSHCHINLDETWT 794
Query: 615 QVSELSQLYKEAQAELEDYRK---RKSLEDVTAEYIHKAEHE---------KLMQLT--- 659
+L Q+ + + + E++RK SL + TA+ I K E K +++T
Sbjct: 795 SKKKLFQVEIQPEEKHEEFRKVFELISLLNYTADQIRKKNRELEEEATGYKKCLEMTINM 854
Query: 660 ---------------NVSRAKAEDALSEMKSQYSKVLNELTQL-KQLVDAQKENSVSITE 703
N + K + ++K ++ ++ E + + V+ K+N V E
Sbjct: 855 LNAFANEDFSCHGDLNTDQLKMDILFKKLKQKFDDLMAEKEAVSSKCVNLAKDNEVLHQE 914
Query: 704 HLQV------ITTLRTAAKEMEEKISNLKEHLASKEVEVAKLE--KQLLEEKAAMTDAMV 755
L + L K +EEK+ NLK H+ VE+ K++ K L+E+A +
Sbjct: 915 LLSMGKVQEKCEKLEKDKKMLEEKVLNLKTHMEKDMVELGKVQEYKSELDERAMQAIEKL 974
Query: 756 PRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKS 815
+K Q+ E ++ L S+K+KE +V + S++K E++ T L+
Sbjct: 975 EEIHLQK-QAEYEKQLEQLNKDNTASLKKKELTLKDV---ECKFSKMKTAYEDVTTELEE 1030
Query: 816 KEQEVNELLQKFQQAQEELAEM-KRYAESSSKLEEDKDK 853
++ L+ E++ + K+ A S+KL +K++
Sbjct: 1031 YKEAFAVALKANSSMSEKITKSDKKIAVISTKLFMEKER 1069
Score = 100 bits (249), Expect = 6e-21
Identities = 194/914 (21%), Positives = 362/914 (39%), Gaps = 146/914 (15%)
Query: 58 HLAAAKGHVECLRVMITHGV-DVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVD 116
H AA KG + +T D+ +D + LHLA + + + LL KC D
Sbjct: 167 HRAAIKGDAAEVEHCLTRRFRDLDVRDKKDRTVLHLACAHGRVQVVTLLLDRKCQINICD 226
Query: 117 SSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGA 176
+T L A IL + + N+KD+ GN L AV N + + LL H A
Sbjct: 227 RLNRTPLMKAVHCQEEACAIILLKRGANPNIKDIYGNTALHYAVYNEGTSLAERLLSHHA 286
Query: 177 DVNSRNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSL 236
++ + NK G T L+ A + VE L+K A+++ VD+ AL + + I +L
Sbjct: 287 NIEALNKEGNTPLLFAINSRRQHMVEFLLKNQANIHAVDNFKRTALILAVQHNLSSIVTL 346
Query: 237 LLSKISQDADLKTPTKPKQLSDVSSPRSITSTPLSGKESVFFAEPPFKAEISSIRENKDR 296
LL + I+S + G+ + +A F ++ SI++
Sbjct: 347 LLQQNIH---------------------ISSQDMFGQTAEDYA---FCCDLRSIQQQ--- 379
Query: 297 LSDSTTGADSLLDISSEADQQDLLSLLQAKVASLTLHNKELQDKLQAKSPKE---AEADL 353
+L+ ++ + L + Q A + K+ + + + K KE AE +L
Sbjct: 380 ----------ILEHKNKMLKNHLRNDNQETAAMKPENLKKRKKRKKLKKRKEGAKAEHNL 429
Query: 354 SFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDVRIQQLQEILQDLQ 413
S + L + P DS+S G D+ + L+E L ++
Sbjct: 430 KVASEEKQER-----LERSENKQPQDSQSYGKKKDEMFGNFMLKRDIAM--LKEELYAIK 482
Query: 414 KRLESSEAERKQLQ-----VELQSRRAELVCLNNTEISENSSDLSQKLKETQSKYEEAMK 468
+S E+K +Q E+ + + V LN I++ + SQ+L + +++ +
Sbjct: 483 N--DSLRKEKKYIQEIKSITEINANFEKSVRLNEEMITKKVAQYSQQLNDLKAE-NARLN 539
Query: 469 EVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESERNKEKVRELE 528
L +K K L E E+ L +L A+ E E+ ++LE
Sbjct: 540 SKLEKEKHNKERL------------------EAEVESLHSNLATAINEYNEILER-KDLE 580
Query: 529 EKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKDTLKS 588
L + V +E M S+ I + + L E+ +A+ + LK L+
Sbjct: 581 LVLWRADD-------VSRHETMGSN----ISQLTDKNELLTEQVHKARVKFNTLKGKLRE 629
Query: 589 QMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLY-----KEAQA--------------E 629
T++A E E++ + + ++ E+ Q++ KE+Q+ E
Sbjct: 630 --TRDALREKTLALESVQLDLKQAQHRIKEMKQMHPNGEAKESQSIGKQNSSEERIRQRE 687
Query: 630 LEDYRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSK-VLNELTQLK 688
LE+ + LED E +K + N+ R E+ ++ + +K ++NE LK
Sbjct: 688 LENLLLERQLEDARKEGDNKEI------VINIHRDCLENGKEDLLEERNKELMNEYNYLK 741
Query: 689 Q-LVDAQKENSV----------SITEHLQVITTLRTAAKEMEEKISNLKEHLASK----E 733
+ L+ +KE + + +HL+ + + + NL E SK +
Sbjct: 742 EKLLQYEKEKAEREVIVREFQEELVDHLKKFSMSESPLEGTSHCHINLDETWTSKKKLFQ 801
Query: 734 VEVAKLEKQLLEEKAAMTDAMVPRSSYE--KLQSSLESEVSVLASKLKESVKEKEKVHSE 791
VE+ EK K +++ ++ + K LE E + L+ ++ +E
Sbjct: 802 VEIQPEEKHEEFRKVFELISLLNYTADQIRKKNRELEEEATGYKKCLEMTINMLNAFANE 861
Query: 792 VVQIRSEVSQ--------VKREKENIQTLLKSKEQEVNE---LLQKFQQAQEELAEMKRY 840
+++ K+ K+ L+ KE ++ L + + +EL M +
Sbjct: 862 DFSCHGDLNTDQLKMDILFKKLKQKFDDLMAEKEAVSSKCVNLAKDNEVLHQELLSMGKV 921
Query: 841 AESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQL-SYSTSSSKRQSQQLEALQQQVKQL 899
E KLE+DK ++ T +++ + L ++ Y + +R Q +E L++ Q
Sbjct: 922 QEKCEKLEKDKKMLEEKVLNLKTHMEKDMVELGKVQEYKSELDERAMQAIEKLEEIHLQK 981
Query: 900 QNQLAECKKQHQEV 913
Q AE +KQ +++
Sbjct: 982 Q---AEYEKQLEQL 992
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 111 bits (277), Expect = 4e-24
Identities = 136/668 (20%), Positives = 290/668 (43%), Gaps = 70/668 (10%)
Query: 285 AEISSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLTLHNKELQDKLQAK 344
A ++ ++E L + T L SE+ +Q A LH++ + K +
Sbjct: 561 AVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQ----------AQENLHDQVQEQKAHLR 610
Query: 345 SPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDVR--I 402
+ ++ L S + + L S K + + +L K+ D++ +
Sbjct: 611 AAQDRVLSLE-TSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHL 669
Query: 403 QQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNN--TEISENSSDLSQKLKETQ 460
Q LQD Q+ L + Q+ +LQ ++ L + E E L QK +E +
Sbjct: 670 DTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELE 729
Query: 461 SKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTE---------EEINVLKQDLQ 511
+ ++ + L V+ + L + + ELR TE E ++ + DLQ
Sbjct: 730 GQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQ 789
Query: 512 NALEESERNKEKV--RELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNK---EKA 566
E E K+K+ +E E+++++++ T+ + ++EE+ + + + + K EK
Sbjct: 790 KKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKE 849
Query: 567 FLFEKYQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEA 626
L + ++++ K+ D+LK+ + E E + I +L K EL +
Sbjct: 850 ALMTELSTVKDKLSKVSDSLKN-----SKSEFEKENQKGKAAILDLEKTCKELKH---QL 901
Query: 627 QAELEDYRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRA--KAEDALSEMKSQYSKVLNEL 684
Q ++E+ K + + E +A H+ ++L ++ +A++ L + + + ++ +
Sbjct: 902 QVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNI 961
Query: 685 TQLKQLVDAQKENSVSITEHLQVITTLRTAAK-EMEEKISNLKEHLASKEVEVAKLEKQL 743
+LKQ + +K+ ++ L++ +T + +++++++ + LA+++ +++ L+
Sbjct: 962 NELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNY 1021
Query: 744 LEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVK 803
EK+ T +++LQS S L + ++ +EK+ + S +Q+
Sbjct: 1022 --EKSQET--------FKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIG 1071
Query: 804 REKENIQTLLKSKEQEVNELLQKFQQAQEELAEM-----------KRYAESSSKLEEDKD 852
+ + IQ L +K + +K QQ QE + K SKL E ++
Sbjct: 1072 NQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEE 1131
Query: 853 KKINEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQLEALQQQVKQLQNQ------LAEC 906
K + KE+TKL E L S S ++ + ++QL L QQ +LQ + E
Sbjct: 1132 IKCRQ-EKEITKLNEELKSHKLESIKEITNLKDAKQL--LIQQKLELQGKADSLKAAVEQ 1188
Query: 907 KKQHQEVI 914
+K++Q+++
Sbjct: 1189 EKRNQQIL 1196
Score = 109 bits (272), Expect = 1e-23
Identities = 141/688 (20%), Positives = 296/688 (43%), Gaps = 114/688 (16%)
Query: 320 LSLLQAKVASLTLHNKELQDKLQAKSPKEAEADLSFDSYHSTQTDLGPSLG-KPGETSPP 378
L L++ V LT N+ L + L K + + + ++ ++ +L K +
Sbjct: 290 LQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQL 349
Query: 379 DSKSSPS-VLIHSLGKSTTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAEL 437
S+ S S +H + ++ Q+L+E L +++ + + +AE KQLQ + + +
Sbjct: 350 QSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQ-- 407
Query: 438 VCLNNTEISENSSDLSQKLKETQSKYEEA---MKEV--LSVQK-----------QMKLGL 481
+ ++ + L KL ET+ + EA +KE LS +K Q+KL
Sbjct: 408 ---HGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSR 464
Query: 482 VSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESERNKEKVRELEEKLVEREKGTVIK 541
+ + + ++ EL+ ++ Q+ Q AL++S K + + + + V R+ G +
Sbjct: 465 LEEQLKEKVTNSTELQHQLDKTKQQHQE-QQALQQSTTAKLREAQNDLEQVLRQIGDKDQ 523
Query: 542 PPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKD------TLKSQMTQ--- 592
++ E + I + KE+ L+ K Q + E L TL+ Q+TQ
Sbjct: 524 K-IQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTE 582
Query: 593 EASDEAEDMKEAMNRMIDELNKQ----------VSELSQLYKEAQAELEDYRKRKSLEDV 642
+ +++E K+A + D++ +Q V L E ++L + +++ S D+
Sbjct: 583 KLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDI 642
Query: 643 T----AEYIHKAEHEKLMQLTNVSRA--KAEDALSEMKSQYSKVLNELTQLKQLVDAQKE 696
E + AE K Q ++ A++AL + + + +K+ +L Q+ + ++E
Sbjct: 643 QIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQE 702
Query: 697 NSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAMVP 756
+ + HL KE +EK +L++ E ++ KLE LE KA+ A+
Sbjct: 703 HCSQLESHL----------KEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQD 752
Query: 757 RSSYEKLQSSLESEVSVLASKLK--------------------ESVKEK----------- 785
+L + LE + L+ +L+ ES+K+K
Sbjct: 753 LQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQIL 812
Query: 786 ---------------EKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEVNELLQKFQQA 830
E++++ + +E+ +VK EKE + T L + + +++++ + +
Sbjct: 813 KQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNS 872
Query: 831 QEELAEMKRYAESSSKLEEDKDKKINEMSKEV-TKLKEALNSLSQLSYSTSSSKRQSQQL 889
+ E + + +++ D +K E+ ++ +++ L +L S K S QL
Sbjct: 873 KSEFEKENQKGKAAIL---DLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQL 929
Query: 890 E----ALQQQVKQLQNQLAECKKQHQEV 913
+ ++Q+Q+ Q QN L + +K+ Q++
Sbjct: 930 KLELNSMQEQLIQAQNTLKQNEKEEQQL 957
Score = 106 bits (265), Expect = 9e-23
Identities = 147/727 (20%), Positives = 313/727 (43%), Gaps = 113/727 (15%)
Query: 288 SSIRENKDRLSDSTTGADSLLDISSEA--DQQDLLSLLQAKVASLTLHNKELQDKLQAKS 345
S + E + +L ++ +SSE D++ ++ LQ K++ L ++L++K+ +
Sbjct: 421 SKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRL---EEQLKEKVTNST 477
Query: 346 PKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDVRIQQL 405
+ + D + + Q +L + ++++ ++ +G D D +IQ L
Sbjct: 478 ELQHQLDKTKQQHQEQQ-----ALQQSTTAKLREAQNDLEQVLRQIG----DKDQKIQNL 528
Query: 406 QEILQDLQKRLESSEAERKQLQVELQSRRAELVCLN-----NTEISENSSDLSQKLKETQ 460
+ +LQ ++ + E ER+ L ++Q+ E LN N + E + L++KLK
Sbjct: 529 EALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQS 588
Query: 461 SKYEEAMKEVLSVQKQMKLGL-----------VSPESMDNYSHFHELRVTEEEINVL--- 506
+++A + + ++ K L S +++ + + +V++ +I +
Sbjct: 589 ESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKT 648
Query: 507 -------------KQDLQNALEESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSS 553
+ DLQN L+ ++ L++K E K T V + K
Sbjct: 649 ELLLSAEAAKTAQRADLQNHLDTAQN------ALQDKQQELNKITTQLDQVTAKLQDKQE 702
Query: 554 YCSVIENMNKEKA----FLFEKYQEAQEEIMKLK-DTLKSQMTQEASDEAEDMKEAMNRM 608
+CS +E+ KE L +K +E + +I KL+ D+L+ + ++E + + + +N
Sbjct: 703 HCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTD 762
Query: 609 ID----------ELNKQVSELSQLYKEAQAELEDYRKRKSLEDVTAEYIHKAEHEKLMQL 658
++ E+ K++ ++L + ++E + K+K + + I K + E L Q
Sbjct: 763 LELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQE 822
Query: 659 TNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSITEHLQ------------ 706
T + + + + ++ KV E L + K+ +++ L+
Sbjct: 823 TKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQK 882
Query: 707 ---VITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAMVPRSSYEKL 763
I L KE++ ++ E+ ++ E L+K L +EK A S KL
Sbjct: 883 GKAAILDLEKTCKELKHQLQVQMENTLKEQKE---LKKSLEKEKEA--------SHQLKL 931
Query: 764 Q-SSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLK----SKEQ 818
+ +S++ ++ + LK++ KE++++ + +++ Q K++ E +Q LK K +
Sbjct: 932 ELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTE 991
Query: 819 EVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYS 878
N+L Q+ QA +ELA K E S L+ + +K E K++ + S+L +
Sbjct: 992 LENKLQQQLTQAAQELAAEK---EKISVLQNNYEKS-QETFKQLQ--SDFYGRESELLAT 1045
Query: 879 TSSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQGQMDEDVQKVLK 938
K ++L Q+ + +NQ+ K QE L + +++D K +
Sbjct: 1046 RQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQE---------LKTAKATLEQDSAKKEQ 1096
Query: 939 QILTMCK 945
Q+ CK
Sbjct: 1097 QLQERCK 1103
Score = 90.9 bits (224), Expect = 5e-18
Identities = 150/696 (21%), Positives = 295/696 (42%), Gaps = 116/696 (16%)
Query: 226 KLSENAGIQSLLLSK-ISQDADLKTPTKPKQLSDVSSPRSITSTPLSGKESVFFAEPPFK 284
K S+ +Q L + ++ D +L+ KQL S T L K A K
Sbjct: 743 KASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSE---ALESIK 799
Query: 285 AEISSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLTLHNKELQDKLQAK 344
+++ E K L L ++ ++L + +Q V L E + +
Sbjct: 800 QKLTKQEEEKQILKQDF----ETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTEL 855
Query: 345 SPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDVRIQQ 404
S + + DS +++++ K G+ + D + + L H L V+++
Sbjct: 856 STVKDKLSKVSDSLKNSKSEFEKENQK-GKAAILDLEKTCKELKHQL-------QVQMEN 907
Query: 405 LQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNT--EISENSSDLSQKLKETQSK 462
+ ++L+K LE + QL++EL S + +L+ NT + + L + E +
Sbjct: 908 TLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQS 967
Query: 463 YEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESERNKE 522
E+ K++ ++Q ++K+ + L+ TE E N L+Q L A +E KE
Sbjct: 968 SEQKKKQIEALQGELKIAV--------------LQKTELE-NKLQQQLTQAAQELAAEKE 1012
Query: 523 KVRELEEKLVEREKGTVIKPPVEEYEEMKSSYC---SVIENMNKEKAFLFEKYQEAQEEI 579
K+ L+ + + E +++++S + S + ++ + EK AQE++
Sbjct: 1013 KISVLQNNYEKSQ---------ETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDL 1063
Query: 580 MKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSL 639
+ ++ + +Q N++I EL + L Q + + +L++ + K+L
Sbjct: 1064 ISNRNQIGNQ----------------NKLIQELKTAKATLEQDSAKKEQQLQE--RCKAL 1105
Query: 640 EDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSV 699
+D+ E K+ EK +L N AE + E+K + K E+T+L + + + K S+
Sbjct: 1106 QDIQKE---KSLKEK--ELVNEKSKLAE--IEEIKCRQEK---EITKLNEELKSHKLESI 1155
Query: 700 SITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAMVPRSS 759
++I+NLK+ A + + KLE L+ KA A V +
Sbjct: 1156 --------------------KEITNLKD--AKQLLIQQKLE---LQGKADSLKAAVEQE- 1189
Query: 760 YEKLQSSLESEVSVLASKLKESVKEKE-KVHSEVVQIRSEVSQVKREKENIQTLLKSKEQ 818
++ Q L+ +V +LK+ EKE K+HSE+ +EKE +K E+
Sbjct: 1190 -KRNQQILKDQVKKEEEELKKEFIEKEAKLHSEI-----------KEKE---VGMKKHEE 1234
Query: 819 EVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEAL-NSLSQLSY 877
+L + E L +K+ +SS + + +K+ +++ E+ L+ + N+ +
Sbjct: 1235 NEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRA 1294
Query: 878 STSSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEV 913
+ ++E LQ +V +LQ +L QE+
Sbjct: 1295 LLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQEL 1330
Score = 90.1 bits (222), Expect = 9e-18
Identities = 125/569 (21%), Positives = 243/569 (42%), Gaps = 91/569 (15%)
Query: 405 LQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENS--SDLSQKLKETQSK 462
L++ +QDLQ L+ + ++L+ EL+ + L E + +D S +L+ + +
Sbjct: 88 LRQEVQDLQASLKEEKWYSEELKKELEKYQG----LQQQEAKPDGLVTDSSAELQSLEQQ 143
Query: 463 YEEAMKEVLSVQK-----QMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNALEES 517
EEA E ++++ + K ++ E D S + E R E +Q + EE
Sbjct: 144 LEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLRE---AAEQKVTRLTEEL 200
Query: 518 ERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQE 577
+ +++L+ +L++R P +E+ +K V
Sbjct: 201 NKEATVIQDLKTELLQR-------PGIEDVAVLKKELVQV-------------------- 233
Query: 578 EIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRK 637
TL MT E E+E +K+ ++ + + +SQL E K
Sbjct: 234 ------QTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSEL---------AK 278
Query: 638 SLEDVTAEYIHKAEHEK--LMQLTNVSRAKAEDALSEMKSQYSKV---LNELTQLKQLVD 692
++V A Y+ + + K + +LT ++ E+ L + + Y+K+ NE + K+ +
Sbjct: 279 GPQEV-AVYVQELQKLKSSVNELTQKNQTLTENLLKK-EQDYTKLEEKHNEESVSKKNIQ 336
Query: 693 AQKENSVSITEHLQV-ITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMT 751
A + LQ ++ T+ + ++S E + E++++E + KA
Sbjct: 337 ATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFK 396
Query: 752 DAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQT 811
R E+ L+SE++ L SKL E+ ++ + H + E Q+ EK
Sbjct: 397 QLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRL----KEQRQLSSEK----- 447
Query: 812 LLKSKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKE-------VTK 864
L KEQ+V +L K + +E+L K +S++L+ DK + ++ K
Sbjct: 448 -LMDKEQQVADLQLKLSRLEEQL---KEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAK 503
Query: 865 LKEALNSLSQLSYSTSSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVIS-VYRMHLLY 923
L+EA N L Q+ ++ Q LEAL Q+ K+ ++ +K+ +++ + +
Sbjct: 504 LREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKE---NISLLEKEREDLYAKIQAGEGET 560
Query: 924 AVQGQMDE---DVQKVLKQILTMCKNQSQ 949
AV Q+ E +Q+ + Q+ KNQS+
Sbjct: 561 AVLNQLQEKNHTLQEQVTQLTEKLKNQSE 589
Score = 80.1 bits (196), Expect = 9e-15
Identities = 115/573 (20%), Positives = 243/573 (42%), Gaps = 70/573 (12%)
Query: 268 TPLSGKESVFFAEPPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKV 327
T ++ + V + E+S++++ ++SDS + S + ++ + +L L K
Sbjct: 836 TTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDL--EKT 893
Query: 328 ASLTLHNKELQDKLQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVL 387
H ++Q + K KE + L + S Q L + S L
Sbjct: 894 CKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKL-------------ELNSMQEQL 940
Query: 388 IHSLGKSTTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNN----- 442
I + + N+ QQLQ + +L++ E + + + LQ EL+ + L N
Sbjct: 941 IQA-QNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQ 999
Query: 443 -TEISENSSDLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEE 501
T+ ++ + +K+ Q+ YE++ + +Q D Y EL T +
Sbjct: 1000 LTQAAQELAAEKEKISVLQNNYEKSQETFKQLQS------------DFYGRESELLATRQ 1047
Query: 502 EINVLKQDLQNALEESERNKEKVRELEEKLVEREK--GTVIKPPVEEYEEMKSSYCSVIE 559
++ +++ L A E+ N+ ++ + KL++ K ++ + E+ C ++
Sbjct: 1048 DLKSVEEKLSLAQEDLISNRNQIGN-QNKLIQELKTAKATLEQDSAKKEQQLQERCKALQ 1106
Query: 560 NMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSEL 619
++ KEK+ ++ + ++ ++++ +K + +E + E++K I E+ + +
Sbjct: 1107 DIQKEKSLKEKELVNEKSKLAEIEE-IKCRQEKEITKLNEELKSHKLESIKEIT-NLKDA 1164
Query: 620 SQLYKEAQAELEDYRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSK 679
QL + + EL+ K SL+ E EK Q + K E+ E+K ++
Sbjct: 1165 KQLLIQQKLELQG--KADSLKAA-------VEQEKRNQQILKDQVKKEE--EELKKEF-- 1211
Query: 680 VLNELTQLKQLVDAQKENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKL 739
+ + +L KE V + +H + L + E + +K+ S + V++L
Sbjct: 1212 ----IEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSEL 1267
Query: 740 EKQL--LEEKAAMTDAMVPRSSYEK---LQSSLESEVSVLASKLKESVKEKEKVHSEVVQ 794
EKQ L + A+ +A V + E+ L+ L+ E + KL+ V E ++ ++
Sbjct: 1268 EKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEI--EKLQTKVLELQR---KLDN 1322
Query: 795 IRSEVSQVKREKENIQ----TLLKSKEQEVNEL 823
+ V ++ RE +++Q L K E NE+
Sbjct: 1323 TTAAVQELGRENQSLQIKHTQALNRKWAEDNEV 1355
Score = 33.5 bits (75), Expect = 0.97
Identities = 23/107 (21%), Positives = 50/107 (46%), Gaps = 6/107 (5%)
Query: 806 KENIQTLLKSKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKL 865
K + TLL+ + Q++ L++ + EEL + + + E D + + S E+ L
Sbjct: 81 KRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSL 140
Query: 866 KEALNSLSQLSYSTSSSKRQSQQLEALQQQVKQLQNQLAECKKQHQE 912
++ QL + + + Q + +Q+ QL ++A+ K ++ E
Sbjct: 141 EQ------QLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDE 181
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 110 bits (274), Expect = 8e-24
Identities = 156/691 (22%), Positives = 316/691 (45%), Gaps = 110/691 (15%)
Query: 308 LDISSEADQQDLLSLL--QAKVASLTLHNKELQDKLQAKSPKE-------AEADLSFDSY 358
L+ S +QQ SL +AK A L L + + +L+A + ++ A+A L+ Y
Sbjct: 1128 LEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLA-SLY 1186
Query: 359 HSTQTDLG------PSLGKPGETSP------PDSKSSPSV-----LIHSLGKSTTDNDV- 400
+ Q LG P L G+++P PD + S+ L+ +L + +
Sbjct: 1187 SALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALH 1246
Query: 401 -------RIQQLQEILQD----LQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENS 449
+ QQ +++L+D L++RL +EAE+ Q+ ELQ + +L ++ E
Sbjct: 1247 KLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQL-----SQNQEEK 1301
Query: 450 SDLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQD 509
S K +S+ E + + S+Q +++ + + M+ L+ +E + +
Sbjct: 1302 SKWEGKQNSLESELMELHETMASLQSRLRRAEL--QRMEAQGERELLQAAKENLTAQVEH 1359
Query: 510 LQNALEESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIEN--------- 560
LQ A+ E+ LEE L R + +K EE E + ++ E
Sbjct: 1360 LQAAVVEARAQASAAGILEEDL--RTARSALKLKNEEVESERERAQALQEQGELKVAQGK 1417
Query: 561 -MNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSEL 619
+ + A L + E +EE+ +TL+ Q+ QE + E K A+ + +L K+ E+
Sbjct: 1418 ALQENLALLTQTLAEREEEV----ETLRGQI-QELEKQREMQKAALELLSLDLKKRNQEV 1472
Query: 620 SQLYKEAQAELEDYRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSK 679
L +E ELE R E++ A E+ +LT V R + + + ++Q +
Sbjct: 1473 D-LQQEQIQELEKCRS-------VLEHLPMAVQEREQKLT-VQREQIRELEKDRETQRNV 1523
Query: 680 VLNELTQLK---QLVDAQKENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEV 736
+ ++L +L+ Q++++Q+ + + L TL A E+EE ++ ++ +
Sbjct: 1524 LEHQLLELEKKDQMIESQRGQVQDLKKQL---VTLECLALELEENHHKME----CQQKLI 1576
Query: 737 AKLEKQLLEEKAAMTDAMVP---RSSYEKLQSS----LESEVSVLASKLKESVKEKEKVH 789
+LE Q ++ A+T + RS + QSS LES +VLA +L+E
Sbjct: 1577 KELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQER-------D 1629
Query: 790 SEVVQIRSEVSQVKREKENIQTLLKSKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEE 849
EV R ++ +++R+KE++ L+ ++QE+ ++ Q +++ + E LE+
Sbjct: 1630 QEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEED--LEQ 1687
Query: 850 DKDKKINEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQLEALQQQVKQLQNQLAECKKQ 909
K + E +E+T ++ + ++ S ++R S LE ++ ++ + ++ EC+++
Sbjct: 1688 IK-LSLRERGRELTTQRQLMQERAEEGKGPSKAQRGS--LEHMKLILRDKEKEV-ECQQE 1743
Query: 910 HQEVISVYRMHLLYAVQGQMDEDVQKVLKQI 940
H +H L ++ Q+++ +Q + +++
Sbjct: 1744 H--------IHELQELKDQLEQQLQGLHRKV 1766
Score = 95.9 bits (237), Expect = 2e-19
Identities = 151/763 (19%), Positives = 340/763 (44%), Gaps = 86/763 (11%)
Query: 246 DLKTPTKPKQLSDVSSPRSITSTPLSGKESVFFAEPPFKAEISSIREN--KDRLSDSTTG 303
+L T + ++ R + GK ++ + + E++ +RE K+R
Sbjct: 814 ELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQEL 873
Query: 304 ADSLLDISSEA--------DQQDLLSLLQAKVASLTLHNKELQDKLQAKSPKEAEADLSF 355
A +L + E +QQ + +QA+ + ++Q ++ KE + L
Sbjct: 874 AKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLL-- 931
Query: 356 DSYHSTQTDLGPS------LGKPGETSPPDSKSSPSVLIHSLGKSTTDNDVRIQQLQEIL 409
++ TQ +L + L + + + + +L L ++ + +Q ++ L
Sbjct: 932 ETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDL 991
Query: 410 QDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSSDLSQKLKETQSKYEEAMKE 469
LQ+ S ++ LQ +++ +++LV ++++ ++ +KL+ETQ +Y KE
Sbjct: 992 AALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQ-EVQEKLRETQ-EYNRIQKE 1049
Query: 470 VLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESERNKEKVRELEE 529
+ + + L L+ E + + ++E++ L+QD+Q A E + ++ L +
Sbjct: 1050 LEREKASLTLSLMEKEQRLLVLQEAD-SIRQQELSALRQDMQEAQGEQKELSAQMELLRQ 1108
Query: 530 KLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKDTLKSQ 589
++ E+E + + EE+++S+ + + +A L+ + +A + ++L+ T +SQ
Sbjct: 1109 EVKEKE-ADFLAQEAQLLEELEASHITE----QQLRASLWAQEAKAAQLQLRLRST-ESQ 1162
Query: 590 MTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELED----------------- 632
+ A+++ + + L + + E++ EL
Sbjct: 1163 LEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNG 1222
Query: 633 ----YRKRKSLEDVTAEYIHKAEHE------KLMQLTNVSR---AKAEDALSEMKSQYSK 679
+++ L ++AE + A H+ K Q +V R K E+ L++ +++ S+
Sbjct: 1223 ARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQ 1282
Query: 680 VLNELTQLKQLVDAQKENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVE--VA 737
V EL L++ + +Q + S E Q +L + E+ E +++L+ L E++ A
Sbjct: 1283 VHTELQDLQRQL-SQNQEEKSKWEGKQ--NSLESELMELHETMASLQSRLRRAELQRMEA 1339
Query: 738 KLEKQLLEE------------KAAMTDAMVPRSSYEKLQSSLESEVSVLASKLKESVKEK 785
+ E++LL+ +AA+ +A S+ L+ L + S L K +E E+
Sbjct: 1340 QGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESER 1399
Query: 786 EKVHSEVVQIRSEVSQVKREKENIQTL---LKSKEQEVNELLQKFQQAQEELAEMKRYAE 842
E+ + Q +V+Q K +EN+ L L +E+EV L + Q+ +++ EM++ A
Sbjct: 1400 ERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQ-REMQKAA- 1457
Query: 843 SSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQLEALQQQVKQLQNQ 902
L D K+ E+ + +++E S L + + + + Q+L ++Q+++L+
Sbjct: 1458 -LELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKD 1516
Query: 903 LAECKK--QHQEVISVYRMHLLYAVQGQMDEDVQKVLKQILTM 943
+ +HQ + + ++ + +GQ VQ + KQ++T+
Sbjct: 1517 RETQRNVLEHQLLELEKKDQMIESQRGQ----VQDLKKQLVTL 1555
Score = 94.4 bits (233), Expect = 5e-19
Identities = 146/715 (20%), Positives = 308/715 (43%), Gaps = 83/715 (11%)
Query: 289 SIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLTLHNKELQDKLQAKSPKE 348
++RE ++RL + G L+ +L++L +A + S L + L+ + +
Sbjct: 517 AVRE-RERLQEMLMG----LEAKQSESLSELITLREA-LESSHLEGELLRQEQTEVTAAL 570
Query: 349 AEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSP---SVLIHSLGKSTTDNDVRIQQL 405
A A+ S S++ L +T D +++ S L +L + ++ QL
Sbjct: 571 ARAEQSIAELSSSENTL--------KTEVADLRAAAVKLSALNEALALDKVGLNQQLLQL 622
Query: 406 QEILQDLQKRLESSEAERKQLQVEL--QSRRAELVCLNNTEI-------SENSSDLSQKL 456
+E Q + R+E++E R LQV+L +R E + NT + E ++L L
Sbjct: 623 EEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADL 682
Query: 457 KETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHE---LRVTEEEINVLKQD--LQ 511
++ Q + EE K++ + Q + E + + E R +E+ ++++ L+
Sbjct: 683 RDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALE 742
Query: 512 NALEESERNKEKVRE-----------LEEKLVE-REKGTVIKPPVEEYEEMKSSYCSVIE 559
L+ ER+++ + E LE L E +++ +VI+ + E + E
Sbjct: 743 VRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKE 802
Query: 560 NMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMT---QEASDEAEDMKEAMNRMIDELNKQV 616
+ E L + + + + +D Q+ QE E K A + +++L ++
Sbjct: 803 VIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKW 862
Query: 617 SELSQLYKEAQAELEDYRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQ 676
+ +++ A+ + +R+ +E + E E + R +AE AL +M+ +
Sbjct: 863 EKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLE 922
Query: 677 YSK------------------VLNELTQLKQLVDAQKENSVSITEHLQVITTLRTAAKEM 718
K +L +L+Q + QK T LQ T L+ A +E+
Sbjct: 923 TEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQ--TQLQEAQREL 980
Query: 719 EEKISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASKL 778
+E ++ LA+ + E + L + ++ + + D + + Q +E EV KL
Sbjct: 981 KEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQ---EKL 1037
Query: 779 KESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKS----KEQEVNELLQKFQQAQEEL 834
+E+ +E ++ E+ + ++ ++ EKE +L+ ++QE++ L Q Q+AQ E
Sbjct: 1038 RET-QEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQ 1096
Query: 835 AEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQLEALQQ 894
E+ A+ +E K+K+ + +++E L+E + S+ T R S L A +
Sbjct: 1097 KELS--AQMELLRQEVKEKEADFLAQEAQLLEEL-----EASHITEQQLRAS--LWAQEA 1147
Query: 895 QVKQLQNQLAECKKQHQEVISVYRMHLLYAVQGQMDEDVQKVLKQILTMCKNQSQ 949
+ QLQ +L + Q + + + + Q Q+ + + + ++C+++ +
Sbjct: 1148 KAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPE 1202
Score = 91.7 bits (226), Expect = 3e-18
Identities = 145/801 (18%), Positives = 330/801 (41%), Gaps = 126/801 (15%)
Query: 251 TKPKQL-SDVSSPRSITSTPLSGKESVFFAEPPFKAEISSIRENKDRLSDSTTGADSLLD 309
T+ +QL + + + + KE++ + + + ++ ++ L++ G S +
Sbjct: 708 TQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKE 767
Query: 310 I--SSEADQQDLLSLLQAKVASLTLHNKELQDKLQAKSPKEAEA---DLSFDSYHSTQTD 364
+ SS + Q S+++ L + ++Q QAK + E L D+ S
Sbjct: 768 LLESSLFEAQQQNSVIEVTKGQLEV---QIQTVTQAKEVIQGEVRCLKLELDTERSQAEQ 824
Query: 365 LGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDVRIQQLQEIL--------QDLQKRL 416
+ + + + K++ L + ++ + QL+E Q+L K L
Sbjct: 825 ERDAAARQLAQAEQEGKTA-------LEQQKAAHEKEVNQLREKWEKERSWHQQELAKAL 877
Query: 417 ESSEAERKQLQVELQSRRAEL-----------------VCLNNTEISENSSDLSQKLKET 459
ES E E+ +L++ L+ ++ E+ +C E + L + L +T
Sbjct: 878 ESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQT 937
Query: 460 QSKYEEAMKEVLSVQKQMKL---------GLVSPESMDNYSHFHEL-RVTEEEINVLKQD 509
Q + +A +++ +++ MK+ G++ + + E R +++ L+++
Sbjct: 938 QKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEE 997
Query: 510 LQNALEESERNKEKVRELEEKLVEREKGT-VIKPPVEEYEEMKSSYCSVIENMNKEKAFL 568
+ L++ +++V +L+ +LV ++ +++ V+E Y + + + +EKA L
Sbjct: 998 SSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASL 1057
Query: 569 FEKYQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQA 628
E ++ ++ L++ S QE S +DM+EA EL+ Q+ L Q KE +A
Sbjct: 1058 TLSLMEKEQRLLVLQEA-DSIRQQELSALRQDMQEAQGEQ-KELSAQMELLRQEVKEKEA 1115
Query: 629 ELEDYRKRKSLEDVTAEYIHK--------AEHEKLMQLTNVSR----------------- 663
+ ++ + LE++ A +I + A+ K QL R
Sbjct: 1116 DFLA-QEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGN 1174
Query: 664 -AKAEDALSEMKSQYSKVLNELTQLKQLV-------------DAQKENSVSITEHLQVIT 709
A+A+ L+ + S + L + + + + + + + S+ + ++T
Sbjct: 1175 QAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLT 1234
Query: 710 TLRTAAKE-------------------MEEKISNLKEHLASKEVEVAKLEKQLLEEKAAM 750
L A + +++ L+E L E E +++ +L + + +
Sbjct: 1235 ALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQL 1294
Query: 751 TDAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQ 810
+ +S +E Q+SLESE+ L + + + ++ + E ++ KEN+
Sbjct: 1295 SQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLT 1354
Query: 811 TLLKSKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALN 870
++ + V E + A L E R A S+ KL+ ++ + E + +AL
Sbjct: 1355 AQVEHLQAAVVEARAQ-ASAAGILEEDLRTARSALKLKNEEVESERERA-------QALQ 1406
Query: 871 SLSQLSYSTSSSKRQS-----QQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAV 925
+L + + +++ Q L +++V+ L+ Q+ E +KQ + + + L
Sbjct: 1407 EQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLK 1466
Query: 926 QGQMDEDVQKVLKQILTMCKN 946
+ + D+Q+ Q L C++
Sbjct: 1467 KRNQEVDLQQEQIQELEKCRS 1487
Score = 88.2 bits (217), Expect = 3e-17
Identities = 114/550 (20%), Positives = 251/550 (45%), Gaps = 48/550 (8%)
Query: 396 TDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRR--AELVCLNNTEISENSSDLS 453
+ D+ +LQ+ + +L L S+ + + + +++ R E++ N+TE+ E+ + LS
Sbjct: 272 SQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRETVEILETNHTELMEHEASLS 331
Query: 454 QKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNA 513
+ +E + ++ +K++ V + + +N ++ + + L
Sbjct: 332 RNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGHENSLELDSSIFSQFDYQDADKALTLV 391
Query: 514 LEESERNKEKVRELEEKLVE-REKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKY 572
R ++ V++L ++L +E +++ +++EE + ++ + E+ L +
Sbjct: 392 RSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQT 451
Query: 573 QEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELED 632
+ Q E+ L + ++ Q+A +E E + + L + EL AQ + E+
Sbjct: 452 VDLQGEVDSLSK--ERELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEE 509
Query: 633 YRKRKSLEDVTAEYIHKA--EHEKLMQLTNVSRAKAEDALSEMKS-----QYSKVLNELT 685
+ E +H A E E+L ++ AK ++LSE+ + + S + EL
Sbjct: 510 QQ----------EELHLAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELL 559
Query: 686 QLKQ--LVDAQKENSVSITEHLQVITTLRTAAKEMEE---KISNLKEHLASKEVEVAKLE 740
+ +Q + A SI E TL+T ++ K+S L E LA +V + +
Sbjct: 560 RQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQL 619
Query: 741 KQLLEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASKLKESVKEK--------EKVHSEV 792
QL EE ++ M + E+ +++L+ +++ A K +E++ EK +K
Sbjct: 620 LQLEEENQSVCSRM---EAAEQARNALQVDLAE-AEKRREALWEKNTHLEAQLQKAEEAG 675
Query: 793 VQIRSEVSQVKREKENIQTLL-KSKEQE------VNELLQKFQQAQEELAEMKRYAESSS 845
++++++ ++ EKE IQ L +S+ Q+ + +L Q+ ++ +E LA + E+
Sbjct: 676 AELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALV 735
Query: 846 KLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQLEALQQQVK-QLQNQLA 904
+ + + ++ + ++ L E L LS SS ++QQ ++ + K QL+ Q+
Sbjct: 736 REKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQI- 794
Query: 905 ECKKQHQEVI 914
+ Q +EVI
Sbjct: 795 QTVTQAKEVI 804
Score = 82.8 bits (203), Expect = 1e-15
Identities = 125/561 (22%), Positives = 245/561 (43%), Gaps = 95/561 (16%)
Query: 415 RLESSEAERKQLQVELQSRRAELVCLNNTEISENSSDLSQKLKETQSKYEEAMKEVLSVQ 474
+L++ E E ++ + + + EL + EN + L+Q L E + + E ++ ++
Sbjct: 1389 KLKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELE 1448
Query: 475 KQMKLGLVSPE--SMDNYSHFHELRVTEEEINVLK------QDLQNALEESERN----KE 522
KQ ++ + E S+D E+ + +E+I L+ + L A++E E+ +E
Sbjct: 1449 KQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQRE 1508
Query: 523 KVRELEE-----------KLVEREK-GTVIKPPVEEYEEMKSSY----CSVIENMNKEKA 566
++RELE+ +L+E EK +I+ + +++K C +E +E
Sbjct: 1509 QIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALEL--EENH 1566
Query: 567 FLFEKYQEAQEEIMKLKDTLKSQMTQEASDEAEDMKE--AMNRMIDELN-------KQVS 617
E Q+ +E+ ++T + +T D E +E A + I +L +++
Sbjct: 1567 HKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQ 1626
Query: 618 ELSQLYKEAQAELEDYRKRKS-----LEDVTAEYIHKAEHEKLMQLTNVSRAKA-EDALS 671
E Q K + ++E+ +++K LE E + + E ++++ + K E+ L
Sbjct: 1627 ERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLE 1686
Query: 672 EMKSQYSKVLNELTQLKQLVDAQKENSVSIT-------EHLQVITTLRTAAKEMEEKISN 724
++K + ELT +QL+ + E + EH+++I LR KE+E +
Sbjct: 1687 QIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLI--LRDKEKEVECQ--- 1741
Query: 725 LKEHLASKEVEVAKLEKQL--LEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASKLKESV 782
+EH+ + +LE+QL L K T ++ S E E+ VL +L+E+
Sbjct: 1742 -QEHIHELQELKDQLEQQLQGLHRKVGETSLLL---------SQREQEIVVLQQQLQEA- 1790
Query: 783 KEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEVNELLQKFQQAQEELAEMKRYAE 842
+E+ + ++S++ + +R L ++QE+ L Q+ QQAQ + +K A+
Sbjct: 1791 --REQGELKEQSLQSQLDEAQRA-------LAQRDQELEALQQEQQQAQGQEERVKEKAD 1841
Query: 843 SSSKLEEDKDKKINEMSKEVTKLKEALNSLSQ---------------LSYSTSSSKRQSQ 887
+ E + E E+ KE L + L + S+ Q +
Sbjct: 1842 ALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEK 1901
Query: 888 QLEALQQQ-VKQLQNQLAECK 907
L ALQQQ +Q Q E +
Sbjct: 1902 ALLALQQQCAEQAQEHEVETR 1922
Score = 81.6 bits (200), Expect = 3e-15
Identities = 157/785 (20%), Positives = 320/785 (40%), Gaps = 117/785 (14%)
Query: 235 SLLLSKISQDADLKTPTKPKQLSDVSSPRSITS-TPLSGKESVFFAEPPFKAEISSIRE- 292
SL L K +Q+ DL+ +Q+ ++ RS+ P++ +E E + IRE
Sbjct: 1462 SLDLKKRNQEVDLQQ----EQIQELEKCRSVLEHLPMAVQER----EQKLTVQREQIREL 1513
Query: 293 NKDRLSDSTTGADSLLDI--------SSEADQQDLLSLLQAKVASLTLHNKELQDKLQAK 344
KDR + LL++ S QDL L + L L +E K++ +
Sbjct: 1514 EKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQL-VTLECLALELEENHHKMECQ 1572
Query: 345 SPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHS--LGKSTTDNDVRI 402
E + ++ T L L + + S + HS L + + D +
Sbjct: 1573 QKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEV 1632
Query: 403 QQLQEILQDLQKRLE--SSEAERKQLQVELQSRRAELVCLNNTE---------------I 445
+ +E +++LQ++ E + + ER+ ++ LQ R +++ T +
Sbjct: 1633 KSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSL 1692
Query: 446 SENSSDLSQKLKETQSKYEEAM---KEVLSVQKQMKLGLVSPESMDN--YSHFHELRVTE 500
E +L+ + + Q + EE K + MKL L E H HEL+ +
Sbjct: 1693 RERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELK 1752
Query: 501 EEINVLKQDLQNALEESE----RNKEKVRELEEKLVE-REKGTV----IKPPVEEYEEMK 551
+++ Q L + E+ + ++++ L+++L E RE+G + ++ ++E +
Sbjct: 1753 DQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRAL 1812
Query: 552 SSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQ------EASDEAEDMKEAM 605
+ +E + +E+ ++ Q +E + + D L+ + Q E E +D KE
Sbjct: 1813 AQRDQELEALQQEQ----QQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQA 1868
Query: 606 NRMIDEL---NKQVSELSQLYKEAQAELEDYRKRK-SLEDVTAEYIHKAEHEKLMQLTNV 661
R+ +EL ++V L ++ + +AE + K +L+ AE EHE +
Sbjct: 1869 RRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQ--EHEVETRALQD 1926
Query: 662 SRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSITEHL-----------QVITT 710
S +A+ L E + + E + +A + + ++ E L Q +
Sbjct: 1927 SWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLE 1986
Query: 711 LRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAMVP-RSSYEKLQSSL-E 768
++ +E + L+ L + + +LE+ L ++ + D + + ++LQ +L +
Sbjct: 1987 QAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQ 2046
Query: 769 SEVSVLASKLKESVKEK---EKVHSEVVQIRSEVSQVKREKE---------NIQTLLKSK 816
+ + + +E + EK ++V ++Q + + Q + E+E +Q L K
Sbjct: 2047 RDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQK 2106
Query: 817 EQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDK---DKKINEMSKEVTKLKEALN--- 870
EQE+ EL + Q E ++ +S +EE D + +E+ +L+ AL
Sbjct: 2107 EQEILELR---ETQQRNNLEALPHSHKTSPMEEQSLKLDSLEPRLQRELERLQAALRQTE 2163
Query: 871 ---------------SLSQLSYSTSSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVIS 915
SL+Q S SS + + L+A + Q +L + + + +
Sbjct: 2164 AREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRRALE 2223
Query: 916 VYRMH 920
R+H
Sbjct: 2224 KERLH 2228
Score = 67.8 bits (164), Expect = 5e-11
Identities = 73/367 (19%), Positives = 154/367 (41%), Gaps = 50/367 (13%)
Query: 573 QEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELED 632
+ AQ ++ K + E S E +K + EL +V+ELS L ++Q + ED
Sbjct: 242 EPAQLLLLLAKTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNED 301
Query: 633 YRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQL----- 687
Y K T E + E + ++SR E+ LS +V+ ++TQ+
Sbjct: 302 YEKMIKALRETVEILETNHTELMEHEASLSRNAQEEKLS-----LQQVIKDITQVMVEEG 356
Query: 688 -KQLVDAQKENSVSITEHL----------QVITTLRTAAKEMEEKISNLKEHLASKEVEV 736
+ ENS+ + + + +T +R+ + + +L++ LA + V
Sbjct: 357 DNIAQGSGHENSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAV 416
Query: 737 AKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIR 796
L++Q E E L +L++ E++ + + V ++
Sbjct: 417 NLLQQQ---------------------HDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQ 455
Query: 797 SEVSQVKREKENIQTLLKSKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKIN 856
EV + +E+E +Q + Q++ L Q+ + + E++ +S+ +E++ ++++
Sbjct: 456 GEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELH 515
Query: 857 EMSKEVTKLKEAL--------NSLSQLSYSTSSSKRQSQQLEALQQQVKQLQNQLAECKK 908
+E +L+E L SLS+L + + + E L+Q+ ++ LA ++
Sbjct: 516 LAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALARAEQ 575
Query: 909 QHQEVIS 915
E+ S
Sbjct: 576 SIAELSS 582
Score = 59.3 bits (142), Expect = 2e-08
Identities = 105/538 (19%), Positives = 224/538 (41%), Gaps = 69/538 (12%)
Query: 401 RIQQLQEILQDLQKRLESSEAERKQLQVELQ-SRRAELVCLNNTEISENSSDLSQKLKET 459
R+Q L+E+L DL R ES E E+ L ++ Q + +A+ + + ++ LKE
Sbjct: 1881 RVQALEEVLGDL--RAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKER 1938
Query: 460 QSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQ-DLQNALEESE 518
+ E E S + Q + E++ + +E ++L+Q +L +LE S
Sbjct: 1939 DQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEAST 1998
Query: 519 RNKEKV--------RELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFE 570
+ R+LEE L +E E ++ Y ++ + + A E
Sbjct: 1999 ATLQASLDACQAHSRQLEEALRIQEG---------EIQDQDLRYQEDVQQLQQALAQRDE 2049
Query: 571 KYQEAQEEIMKLKDTLKSQMTQEASDEAEDM-KEAMNRMIDELNKQVSELSQLYKEAQAE 629
+ + QE L+ +L ++ + E +++ +E I L++ V EL + + E
Sbjct: 2050 ELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQE 2109
Query: 630 LEDYRK---RKSLEDVTAEYIHKAEHEKLMQLTNVS---RAKAEDALSEMKSQYSKVLNE 683
+ + R+ R +LE + + E+ ++L ++ + + E + ++ ++ +
Sbjct: 2110 ILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSLEPRLQRELERLQAALRQTEAREIEW 2169
Query: 684 LTQLKQLVDAQKENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQL 743
+ + L + + S++ +V L+ + E + + L++ L E+ LEK+
Sbjct: 2170 REKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDEL---ELTRRALEKER 2226
Query: 744 LEEKAAMTDAMVPRSSYEKLQ----SSLESEVSVLASK----------LKESVK----EK 785
L A + A + + +Q S +E+E S + L+++V ++
Sbjct: 2227 LHSPGATSTAELGSRGEQGVQLGEVSGVEAEPSPDGMEKQSWRQRLEHLQQAVARLEIDR 2286
Query: 786 EKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEVNELLQKFQQAQEELAEMKRYAESSS 845
++ VQ+RS + QV+RE+ ++ + + AQ E+ + SS
Sbjct: 2287 SRLQRHNVQLRSTLEQVERERRKLKR-------------EAMRAAQAGSLEISKATASSP 2333
Query: 846 KLEEDKDKK------INEMSKEVTKLKEALN-SLSQLSYSTSSSKRQSQQLEALQQQV 896
++ + +K + E+ KEV L+ L Q + S + S++L L +
Sbjct: 2334 TQQDGRGQKNSDAKCVAELQKEVVLLQAQLTLERKQKQDYITRSAQTSRELAGLHHSL 2391
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 109 bits (273), Expect = 1e-23
Identities = 161/750 (21%), Positives = 314/750 (41%), Gaps = 109/750 (14%)
Query: 194 EIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKTPTKP 253
++ + +AL+K+ + L D L +++SEN I L++ + +D +
Sbjct: 1083 KLAAEEQFQALVKQ-MNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALV 1141
Query: 254 KQLSDVSSPRSITSTPLSGKESVFFAEPPFKAEISSIRENKD----RLSDSTTGADSLLD 309
K+ + S P +G + +P + +I ++ + K+ +L ++ T ++L
Sbjct: 1142 KETV-------VISPPCTGSSEHW--KPELEEKILALEKEKEQLQKKLQEALTSRKAILK 1192
Query: 310 ISSEADQQDLLSLLQAKVASLTLHNKELQDKLQAKSPKEAEADLSF-DSYHSTQTDLGPS 368
+ E ++ L Q K+ ++LQ + ++++ + + D Q + S
Sbjct: 1193 KAQEKERHLREELKQ---------QKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRES 1243
Query: 369 L-GKPGETSPPDSKSSPSVLIHSLGKSTTDNDVRIQQLQEILQDLQKRLESSEAERKQLQ 427
+ GK T +S SS L L K+T + + + D S +A Q
Sbjct: 1244 IDGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSH--SEDASALQGG 1301
Query: 428 VELQSRRAELVCLNNTEISENSSDLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESM 487
+ +A+L EI +L K+ T S+ + +EV +Q+Q+ + ES+
Sbjct: 1302 TSVAQIKAQL-----KEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESL 1356
Query: 488 DNYSHFHELRVTEEEINVLKQDLQNALEESE---RNKEKVRELEEKLVEREKGTVIKPPV 544
SH E V + LQ LE S+ E +REL+ KL E +K
Sbjct: 1357 KTVSH---------EAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQK-------- 1399
Query: 545 EEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEA 604
+I ++ ++L + E + + K++ + Q ED+ +A
Sbjct: 1400 ------------LISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQ---------EDLIKA 1438
Query: 605 MNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRA 664
++ +L Q E + K+ Q EL + +++ E++ E K + ++ +Q +SR
Sbjct: 1439 LHT---QLEMQAKEHDERIKQLQVELCEMKQKP--EEIGEESRAKQQIQRKLQAALISRK 1493
Query: 665 KAEDALSEMKSQYSKVLNELTQL-KQLVDAQKENSVSITEHLQVITTLRTAAKEMEEKIS 723
+A ++ + S + +L K L D + + S E V+ L +E ++ I+
Sbjct: 1494 EALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLIT 1553
Query: 724 NLKEHLASKEVEVAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASKLKESVK 783
+ L + + E L + D E L+SS +E + K KE K
Sbjct: 1554 EMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQK 1613
Query: 784 EKE-------KVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEVNELLQKFQQAQEELAE 836
E E V +E +I+ V V++EK+ + L+S E E ++ Q+A++E+ E
Sbjct: 1614 EYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEE 1673
Query: 837 MK----RYAESSS----KLEEDKDKKINEMSKEVTKLKEALNSL-------------SQL 875
MK ++A+S +LEE+ D+ E+ KE + +L ++
Sbjct: 1674 MKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKM 1733
Query: 876 SYSTSSSKRQS--QQLEALQQQVKQLQNQL 903
Y T S K QS + ++L ++V+ L++Q+
Sbjct: 1734 EYETLSKKFQSLMSEKDSLSEEVQDLKHQI 1763
Score = 108 bits (271), Expect = 2e-23
Identities = 145/732 (19%), Positives = 323/732 (44%), Gaps = 87/732 (11%)
Query: 232 GIQSLLLSKISQDADLKTPTKPKQLSDVSSPRSITSTPLSGKESVFFAE--------PPF 283
G QS+ QD+ L T+P V S +S + P K+ E
Sbjct: 1789 GTQSIPGETEEQDS-LSMSTRPTCSESVPSAKS--ANPAVSKDFSSHDEINNYLQQIDQL 1845
Query: 284 KAEISSIRENKDRLSD-STTGADSLLDISSEADQQD-LLSLLQAKVASLTLHNKELQDKL 341
K I+ + E K + + S T + + S+ +D L +LQ +V + L N+++Q++L
Sbjct: 1846 KERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEEL 1905
Query: 342 ----QAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTD 397
+ K E E D + + +L S+G + + TD
Sbjct: 1906 SRVTKLKETAEEEKDDLEERLMNQLAELNGSIG-------------------NYCQDVTD 1946
Query: 398 NDVRIQQLQEILQDLQKRLESSEAERKQL-----QVELQSRRAELVCLNNTEIS----EN 448
++ + L+ +++L+K + E E++QL +VE + R+ L + + +
Sbjct: 1947 AQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSH 2006
Query: 449 SSDLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQ 508
+ +L + LKE Q + ++ K+ + Q+++ + ++++ +++++ + K+
Sbjct: 2007 AKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQ-----TESQKDLEITKE 2061
Query: 509 DLQNALEESERNKEKVRELEEKL--VEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKA 566
+L A+E ++ + ++ + L + E V+ ++ +E++S+ SV M ++
Sbjct: 2062 NLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDE 2121
Query: 567 FLFEKYQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQL---- 622
L + ++A+E+ +K K ++ ++ ++ ++E + + LNK+ E+ QL
Sbjct: 2122 DLERRLEQAEEKHLKEKKNMQEKLDALRREKVH-LEETIGEIQVTLNKKDKEVQQLQENL 2180
Query: 623 ---------YKEAQAELEDYRKR-----KSLEDVTAEYIHKAEHEKLMQLTNVSRAKAED 668
+ ++ + L+D R R K E ++ I E E ++ N S K D
Sbjct: 2181 DSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLK--D 2238
Query: 669 ALSEMKSQYSKVLNELTQL---KQLVDAQKENSVSITEHLQVITTLRTAAKEMEEKISNL 725
L +M ++ +++L KQ+ +++ + V + + +V TL+ KE+ ++
Sbjct: 2239 QLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQ--KVCDTLQGENKELLSQLEET 2296
Query: 726 KEHLASKEVEVAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASKLKESVKEK 785
+ S + E+AKLE +L K +TD ++ + +LE + + ++ S
Sbjct: 2297 RHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSY 2356
Query: 786 EKVHSEVVQIRSEVSQVKRE----KENIQTLLKSKEQEVNELLQKFQQAQEELAEMKRYA 841
E++ +++ R S++ E ++ I +LL KE+ + + + +Q ++ E+K
Sbjct: 2357 EQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDK--EIKELE 2414
Query: 842 ESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQLEALQQQVKQLQN 901
S+ EE+ E K V K + + +L + + +Q QL++ + + LQN
Sbjct: 2415 NLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIK---KENIQQKAQLDSFVKSMSSLQN 2471
Query: 902 QLAECKKQHQEV 913
+Q++
Sbjct: 2472 DRDRIVGDYQQL 2483
Score = 105 bits (262), Expect = 2e-22
Identities = 158/740 (21%), Positives = 320/740 (43%), Gaps = 90/740 (12%)
Query: 222 LHYSKLSENAGIQSLLLSKISQDADLKTPTKPKQLSDVSSPRSITSTPLSGKESVFFAEP 281
L++S +E A ++S L S Q DL + K + I + ++ F+
Sbjct: 2299 LYHSSQNELAKLESELKSLKDQLTDLSNSLE-KCKEQKGNLEGIIRQQEADIQNSKFSYE 2357
Query: 282 PFKAEISSIRENKDRLSDSTTGAD----SLLDISSEADQQDLLSLLQAKVASLTLHNKEL 337
+ ++ + RE RL + + SLL EA Q + L Q H+KE+
Sbjct: 2358 QLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQ-------HDKEI 2410
Query: 338 QDKLQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDS---KSSPSVLIHSLGKS 394
++ L+ +E E ++ + + D L + +T ++ K+ + S+
Sbjct: 2411 KE-LENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSL 2469
Query: 395 TTDNDVRI---QQLQE----ILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISE 447
D D + QQL+E I+ + + ++ + AE +L+ E++ R+ + LN SE
Sbjct: 2470 QNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLN----SE 2525
Query: 448 NSSDLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDN------YSHFHE-LRVTE 500
N+ KL +Y E + +V++++ + L+ + N Y+ E L+ +E
Sbjct: 2526 NA-----KLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESE 2580
Query: 501 E-------EINVLKQDLQNALEESERNKEKVRELEEKLVE-REKGTV------IKPPVEE 546
E N L+++ Q+ +E E K + +L ++ +E+GT+ +K EE
Sbjct: 2581 EANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEE 2640
Query: 547 YEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMN 606
+ + + S + + + + L +EA +++ +++D LK ++ D M
Sbjct: 2641 VHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAG-----IMR 2695
Query: 607 RMIDELNKQVSELSQLYKEAQAELEDYRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKA 666
+ ++V+EL++ E + +L K + +TA+ ++ + L N SR A
Sbjct: 2696 NETETAEERVAELARDLVEMEQKLLMVTKEN--KGLTAQI--QSFGRSMSSLQN-SRDHA 2750
Query: 667 EDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSITEHLQVITTLRTAAKEMEEKISNLK 726
+ L E+K +Y L EL QLK+ +E ++E A M N
Sbjct: 2751 NEELDELKRKYDASLKELAQLKEQGLLNRERDALLSE----------TAFSMNSTEENSL 2800
Query: 727 EHLASKEVEVAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKE 786
HL ++ ++QLL + + D+ S+ K +SL++E L ++L++ K +E
Sbjct: 2801 SHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFRKSEE 2860
Query: 787 KVHSEVVQIRSEVSQVKREKENIQTLLKSKE---QEVNELLQKFQQAQEELAEMKRYAES 843
Q + ++V+ K+ + +L ++ +E+ L Q++ Q +E+ E+
Sbjct: 2861 GKQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEITELH---PL 2917
Query: 844 SSKLEEDKDK------KINEMSKEVTKLKEALNSL--SQLSYSTSSSKRQSQQLEAL--- 892
++L+E +DK E+ +E + L+ L + S+ + + Q L A+
Sbjct: 2918 KAQLQEYQDKTKAFQIMQEELRQENLSWQHELHQLRMEKSSWEIHERRMKEQYLMAISDK 2977
Query: 893 QQQVKQLQNQLAECKKQHQE 912
QQ+ LQN + E + +
Sbjct: 2978 DQQLSHLQNLIRELRSSSSQ 2997
Score = 104 bits (260), Expect = 3e-22
Identities = 138/613 (22%), Positives = 256/613 (41%), Gaps = 94/613 (15%)
Query: 387 LIHSLGKSTTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEIS 446
LI + +S +N Q L + L+ LE ++++L E++S ++ + +TE
Sbjct: 1551 LITEMDRSLLEN----QSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIA-ESTEWQ 1605
Query: 447 ENSSDLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVL 506
E +L ++ + YE E +Q ++ V E + Y +LR TE
Sbjct: 1606 EKHKELQKEYEILLQSYENVSNEAERIQHVVEA--VRQEKQELYG---KLRSTEANKKET 1660
Query: 507 KQDLQNALEESERNKEKVREL----EEKLVEREK------------GTVIKPPVEEYEEM 550
++ LQ A +E E KEK+R+ ++K++E E+ G K +E
Sbjct: 1661 EKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSS 1720
Query: 551 KSSYCSVIENMNKEKAFLFEKYQEAQ-------EEIMKLKDTLKSQMTQEASDEAEDMKE 603
+S +E + E L +K+Q EE+ LK ++ ++++A+ EA + +
Sbjct: 1721 NASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHD 1780
Query: 604 AMNRMIDELNKQVS---------------ELSQLYKEAQAELEDYRKRKSLEDVTAEYIH 648
+ +E + + S+ A++ K S D Y+
Sbjct: 1781 NQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQ 1840
Query: 649 KAEH--------EKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVS 700
+ + E+ Q E+ + + SQ S EL L++ V +
Sbjct: 1841 QIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQ 1900
Query: 701 ITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAMVPRSSY 760
I E L +T L+ A EE+ +L+E L + ++A+L + +TDA +
Sbjct: 1901 IQEELSRVTKLKETA---EEEKDDLEERLMN---QLAELNGSIGNYCQDVTDAQIKNELL 1954
Query: 761 EKLQSSLESEVSVLASKLKESVKEKEKVHSEV-------VQIRSEVSQVKREKENIQTLL 813
E +L+ VS L + ++ VKEK KV SE+ +Q + K + +Q LL
Sbjct: 1955 ESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELL 2014
Query: 814 KSKEQEVNELLQKFQQAQEELAEMKRYAESSS--KLEEDKDKKINE--MSKEVTKLKEAL 869
K K+QEV +L + + QE+++ ++R ++ + E KD +I + +++ V K+A
Sbjct: 2015 KEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQ 2074
Query: 870 NSLSQLSYSTSSSKRQSQQLEALQQQV---KQLQNQLAECKKQHQEVISVYRMHLLYAVQ 926
L+ S+ QS+ L + K+LQ+ K Q +
Sbjct: 2075 AELA--SFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMK--------------- 2117
Query: 927 GQMDEDVQKVLKQ 939
Q DED+++ L+Q
Sbjct: 2118 -QKDEDLERRLEQ 2129
Score = 102 bits (255), Expect = 1e-21
Identities = 129/587 (21%), Positives = 265/587 (45%), Gaps = 69/587 (11%)
Query: 404 QLQEILQDLQKRLESSE---AERKQLQVELQSRRAELVCLNNTEISENSSDLSQKLKETQ 460
+LQ I +DL+++L + E A KQ+ LQ + ++ L EISEN + + QKL +
Sbjct: 1072 ELQHIRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQ-AEISENQA-IIQKLITSN 1129
Query: 461 SKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHF-----HELRVTEEEINVLKQDLQNALE 515
+ + SV + ++SP + H+ ++ E+E L++ LQ AL
Sbjct: 1130 TDASDGD----SVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALT 1185
Query: 516 ESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEA 575
+ +K +E E L E +K ++Y ++ + + +KE + ++ ++
Sbjct: 1186 SRKAILKKAQEKERHLREE-----LKQQKDDYNRLQEQF----DEQSKENENIGDQLRQL 1236
Query: 576 QEEIMKLKD-TLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYR 634
Q ++ + D L S QE+ ++E + + ++ + Q S L + + ED
Sbjct: 1237 QIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDAS 1296
Query: 635 K----------RKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNEL 684
+ L+++ AE K E E + T K + + +++ Q +K E+
Sbjct: 1297 ALQGGTSVAQIKAQLKEIEAE---KVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEI 1353
Query: 685 TQLKQLVDAQKENSVSITEHLQVITTLRTAA----KEMEEKISNLKEHLASKEVEVAKLE 740
LK + + ++ S+ + L+ + L+ A +E++ K+ L++ ++ KE +V+ L
Sbjct: 1354 ESLKTVSHEAEVHAESLQQKLES-SQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLS 1412
Query: 741 KQLLEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVS 800
QL E++AA+T E L +L +++ + A + E +K+ + E+ Q E+
Sbjct: 1413 GQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIG 1472
Query: 801 QVKREKENIQTLLKSKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSK 860
+ R K+ IQ L++ E L++ + QEEL+ + E +K D + +++ +K
Sbjct: 1473 EESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNK 1532
Query: 861 E------------------VTKLKEALNSLSQLSYSTSSSKRQSQQL----EALQQQVKQ 898
E +T++ +L LS S S K + L E L ++++
Sbjct: 1533 EKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIES 1592
Query: 899 LQN----QLAECKKQHQEVISVYRMHL-LYAVQGQMDEDVQKVLKQI 940
L++ + E +++H+E+ Y + L Y E +Q V++ +
Sbjct: 1593 LKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAV 1639
Score = 88.2 bits (217), Expect = 3e-17
Identities = 124/583 (21%), Positives = 237/583 (40%), Gaps = 76/583 (13%)
Query: 388 IHSLGKSTTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRR------AELVCLN 441
IHSL DV+I+ LQ L D+Q + + LQ +LQ++ AE V
Sbjct: 798 IHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHI 857
Query: 442 NTEISENSSDLSQK-----------------LKETQSKYEEAMKEVLSVQKQMKLGLVSP 484
++++ E S LSQK ++ Q EE ++V + M +V
Sbjct: 858 SSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQL 917
Query: 485 ESMDNYSHFHELRVTEEEINVLKQDLQNALEESERNKEKVRELEEKLVERE-KGTVIKPP 543
+ +S E++ +E++N+L + + E+ E + E L++ E G + K
Sbjct: 918 NE-EKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEE 976
Query: 544 VE--------EYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEAS 595
++ E E+ K + + N + L ++ +EE+ LKD K ++ +
Sbjct: 977 LQHEFDLLKKENEQRKRKLQAALINRKE----LLQRVSRLEEELANLKDESKKEIPLSET 1032
Query: 596 DEAEDMKEAMNRMIDE--LNKQVSELSQLYKE--AQAELEDYRKRKSLEDVTAEYIHKAE 651
+ E ++ N+ E + + E+ K+ ++ E+E RK LE+ A
Sbjct: 1033 ERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQA 1092
Query: 652 HEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSITEHLQVITTL 711
K M T + D L S+ ++ +L + DA +SV++ + VI+
Sbjct: 1093 LVKQMNQTLQDKTNQIDLLQAEISENQAIIQKL--ITSNTDASDGDSVALVKETVVISPP 1150
Query: 712 RTAAK-----EMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAMVPRSSYEKLQSS 766
T + E+EEKI L++ KE KL++ L KA + A +
Sbjct: 1151 CTGSSEHWKPELEEKILALEK---EKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQ 1207
Query: 767 LESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEVNELLQK 826
+ + + L + E KE E + ++ Q++ +V +E+I L S +Q+ E
Sbjct: 1208 QKDDYNRLQEQFDEQSKENENIGDQLRQLQIQV------RESIDGKLPSTDQQ--ESCSS 1259
Query: 827 FQQAQEELAEMKRYAESSSKLEED---------KDKKINEMSKEVTKLKEALNSLS---- 873
+E L + + LE + +D + V ++K L +
Sbjct: 1260 TPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKV 1319
Query: 874 ----QLSYSTSSSKRQSQQLEALQQQVKQLQNQLAECKKQHQE 912
++S +TS ++S+++ LQ+Q+ + ++ K E
Sbjct: 1320 ELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHE 1362
Score = 85.5 bits (210), Expect = 2e-16
Identities = 183/872 (20%), Positives = 330/872 (37%), Gaps = 212/872 (24%)
Query: 252 KPKQLSDVSSPRSITSTPLSGKESVFFAEPPFKAEISSIRENKDRLSDSTTGADSLLDIS 311
K + +S + + S T + ++ V + F+ ++ R ++D L T AD
Sbjct: 195 KEEFISTLQAQLSQTQAEQAAQQVVREKDARFETQV---RLHEDELLQLVTQADV----- 246
Query: 312 SEADQQDLLSLLQAKVASLTLHNKELQDKLQAKSPKEAEADLSFDSYHSTQTDLGP---- 367
E + Q L +LQ K+ H + L + Q + E + L
Sbjct: 247 -ETEMQQKLRVLQRKLEE---HEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAE 302
Query: 368 --SLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDVRIQQLQEILQDLQKRLESSEAERKQ 425
+L ET +SK +L+ + + + LQE + L ++ E + Q
Sbjct: 303 HNTLRNTVETEREESK----ILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAG----Q 354
Query: 426 LQVELQSRRAELVCLNNTEISENSSDL------------------SQKLKETQSKYEEAM 467
Q EL+SR + L + E+ E +S + Q K Q K E+A+
Sbjct: 355 AQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSACDALKDQNSKLLQDKNEQAV 414
Query: 468 KEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESERNKEKVREL 527
+ ++Q+ + + + + L+ E D+ N ++ +E + L
Sbjct: 415 QSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAV-TEENIASL 473
Query: 528 EEKLVE--REKGTVIKPPVEEYEEMK------SSYCSVIENMN----------------- 562
++++VE EKG ++ +E EE+K SS +++E N
Sbjct: 474 QKRVVELENEKGALLLSSIE-LEELKAENEKLSSQITLLEAQNRTGEADREVSEISIVDI 532
Query: 563 ------------------------KEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEASDEA 598
KE + L + +EAQEEI LK L+ + +EA E
Sbjct: 533 ANKRSSSAEESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAEEADHEV 592
Query: 599 EDMKEAMNRMIDE--------------------LNKQVSELSQLYKEAQAELEDYRKRK- 637
D KE M +M E + + S L + KE QA E +
Sbjct: 593 LDQKE-MKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKE-QASTEHQSRTSE 650
Query: 638 --SLEDVTAEY-IHKAEHEKLMQLTNVSRAKAEDALSEMKSQ--------------YSKV 680
SL D E K + +K + +D L +KSQ Y K
Sbjct: 651 EISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQILELELNFHKAQEIYEKN 710
Query: 681 LN----ELTQLKQLVDAQKENS-----------------VSITEHLQVITTLRTAAKEME 719
L+ E++ L QL++ K+N+ +S + L ++T LR K++E
Sbjct: 711 LDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQVKELSMVTELRAQVKQLE 770
Query: 720 -------------------------EKISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAM 754
E+I +L SK+V++ L+ +L D
Sbjct: 771 MNLAEAERQRRLDYESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNEL-------DDVQ 823
Query: 755 VPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLK 814
+ S L SL+S++ S++ E + + S+V ++ +SQ + E + LL
Sbjct: 824 LQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEELSQALSQKELEITKMDQLLL 883
Query: 815 SKEQEVNELLQKFQQAQEELAEMK-RYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLS 873
K+++V L Q ++ +++ E+ E +L E+K + E+ LKE LN LS
Sbjct: 884 EKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEK----FSLGVEIKTLKEQLNLLS 939
Query: 874 QL------------SYSTSSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHL 921
+ S+ + + A Q ++LQ++ KK++++ R
Sbjct: 940 RAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQ-----RKRK 994
Query: 922 LYAVQGQMDEDVQKV--LKQILTMCKNQSQKK 951
L A E +Q+V L++ L K++S+K+
Sbjct: 995 LQAALINRKELLQRVSRLEEELANLKDESKKE 1026
Score = 77.8 bits (190), Expect = 4e-14
Identities = 106/490 (21%), Positives = 209/490 (42%), Gaps = 63/490 (12%)
Query: 494 HELRVTEEEINVLKQDLQNALEES---ERNKEKVRELEEKLVEREKGTVIKPPVEEYEEM 550
HEL ++ ++ L L + E N +++E+L E+ V E+
Sbjct: 14 HELSGDDDTDQNMRAPLDPELHQESDMEFNNTTQEDVQERLAYAEQLVV---------EL 64
Query: 551 KSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMID 610
K + ++ L E+ + A +I KLK K+++T ++N+ I+
Sbjct: 65 KDIIRQKDVQLQQKDEALQEERKAADNKIKKLKLHAKAKLT------------SLNKYIE 112
Query: 611 ELNKQVSELSQLYKEAQAELEDYRKRKSLEDVTAEYI-HKAEHEKLMQLTNVSRAKAEDA 669
E+ Q + +++ +L + K + E++ E I HK + ++ +L + +A+ A
Sbjct: 113 EMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKE--ELISTLQAQLTQA 170
Query: 670 LSEMKSQYSKVLNELTQLKQLVDAQKENSVSITEHLQVITTLRTAAKEMEEKISNLKEHL 729
+E +Q S + E +KQ + ++E ++ L + A + + EK + + +
Sbjct: 171 QAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAAQQVVREKDARFETQV 230
Query: 730 ASKEVEVAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLESE---VSVLASKLKESVKEKE 786
E E+ +L Q E V + E+ + SL V +L +L + + +
Sbjct: 231 RLHEDELLQLVTQADVETEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQRNQ 290
Query: 787 KVHSEVVQIRSEVSQ----VKREKENIQTLLKSKEQEVNE--------------LLQKFQ 828
+ ++ Q+ +E + V+ E+E + LL+ E EV E LL++F+
Sbjct: 291 ILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQFE 350
Query: 829 QAQEELAEMK-RYA--ESSSKLE-EDKDKKINEMSKEVTKLKEALNSLSQLSYSTSSSKR 884
QA + AE++ RY+ E K E E+K I + K +L+ A ++L + K
Sbjct: 351 QAGQAQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSACDALKDQNSKLLQDKN 410
Query: 885 QS--------QQLE-ALQQQVKQLQNQLAECKKQHQEVISVYRMHLLY--AVQGQMDEDV 933
+ QQLE LQQ+ K++ L Q E S +Y Q +E++
Sbjct: 411 EQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTEENI 470
Query: 934 QKVLKQILTM 943
+ K+++ +
Sbjct: 471 ASLQKRVVEL 480
Score = 70.1 bits (170), Expect = 9e-12
Identities = 102/505 (20%), Positives = 224/505 (44%), Gaps = 81/505 (16%)
Query: 395 TTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSSDLSQ 454
T + R+ +L L +++++L E K L ++QS + L N+ N +
Sbjct: 2698 TETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHAN-----E 2752
Query: 455 KLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNAL 514
+L E + KY+ ++KE+ +++Q GL++ E + ++E ++ + +N+L
Sbjct: 2753 ELDELKRKYDASLKELAQLKEQ---GLLNRE--------RDALLSETAFSMNSTE-ENSL 2800
Query: 515 EESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLF---EK 571
E+ +++ +E+L+ + +E+ S+ + ++ E+ L+ EK
Sbjct: 2801 SHLEKLNQQLLSKDEQLLH------LSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEK 2854
Query: 572 YQEAQEEIMKLK----------DTLKSQMTQEASDEAEDMKEAMN--RMIDELNKQVSEL 619
+++++E + +LK M+ +D +KE N + ++N++++EL
Sbjct: 2855 FRKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEITEL 2914
Query: 620 SQLYKEAQAELEDYRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSE--MKSQY 677
L +A+L++Y+ + + E + + +L + K+ + E MK QY
Sbjct: 2915 HPL----KAQLQEYQDKTKAFQIMQEELRQENLSWQHELHQLRMEKSSWEIHERRMKEQY 2970
Query: 678 SKVLNE----LTQLKQLVDAQKENSVSITEHLQVITTLRTAAKE---------------- 717
+++ L+ L+ L+ + +S S T+ L+V R A+ E
Sbjct: 2971 LMAISDKDQQLSHLQNLIRELRSSS-SQTQPLKV-QYQRQASPETSASPDGSQNLVYETE 3028
Query: 718 -MEEKISNLKEHLASKEVEVAKLEK---QLLEEKAAMTDAMVPRSSYEKLQSSLESEVSV 773
+ ++++ + + KE+ + +L QLLEEK ++ + S SL
Sbjct: 3029 LLRTQLNDSLKEIHQKELRIQQLNSNFSQLLEEKNTLSIQLCDTSQ------SLRENQQH 3082
Query: 774 LASKLKE-SVKEKEKVHSEVVQIRSEVSQ-VKREKENIQTLLKSKEQEVNELLQKFQQAQ 831
L +V EK+ + + +V+ +EK + KS +E+ E Q F +AQ
Sbjct: 3083 YGDLLNHCAVLEKQVQELQAGPLNIDVAPGAPQEKNGVHR--KSDPEELREPQQSFSEAQ 3140
Query: 832 EELAEMKRYAESSSK-LEEDKDKKI 855
++L ++ K LEE++D+++
Sbjct: 3141 QQLCNTRQEVNELRKLLEEERDQRV 3165
Score = 37.7 bits (86), Expect = 0.051
Identities = 81/400 (20%), Positives = 159/400 (39%), Gaps = 45/400 (11%)
Query: 197 SSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKTPTKPKQL 256
S N V++ K A L +N L + SE G Q + A++++ K +
Sbjct: 2827 SYNQVQSFSKAMASLQNERDHLWNELEKFRKSEE-GKQRSAAQPSTSPAEVQS--LKKAM 2883
Query: 257 SDVSSPRSITSTPLSGKESVFFAEPPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQ 316
S + + R L + + EI+ + K +L + + + E Q
Sbjct: 2884 SSLQNDRDRLLKELKNLQQQYLQ---INQEITELHPLKAQLQEYQDKTKAFQIMQEELRQ 2940
Query: 317 QDL-----LSLLQAKVASLTLHNKELQDK-LQAKSPKEAEADLSFD---SYHSTQTDLGP 367
++L L L+ + +S +H + ++++ L A S K+ + + S+ + P
Sbjct: 2941 ENLSWQHELHQLRMEKSSWEIHERRMKEQYLMAISDKDQQLSHLQNLIRELRSSSSQTQP 3000
Query: 368 SLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDVRIQQLQEILQDLQKRLESSEAERKQLQ 427
+ + P++ +SP G + + + Q L D K + E +QL
Sbjct: 3001 LKVQYQRQASPETSASPD------GSQNLVYETELLRTQ--LNDSLKEIHQKELRIQQLN 3052
Query: 428 VELQSRRAELVCLNNTEISENSSDLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESM 487
S ++L+ NT +S D SQ L+E Q Y + + ++KQ++ P ++
Sbjct: 3053 ----SNFSQLLEEKNT-LSIQLCDTSQSLRENQQHYGDLLNHCAVLEKQVQELQAGPLNI 3107
Query: 488 D-------------NYSHFHELRVTEEEINVLKQDLQNALEESERNKEKVRELEEKLVER 534
D S ELR ++ + +Q L N +E ++ + E ++ V
Sbjct: 3108 DVAPGAPQEKNGVHRKSDPEELREPQQSFSEAQQQLCNTRQEVNELRKLLEEERDQRVAA 3167
Query: 535 EKG-TVIKPPVE--EYEEMKSSYCSVIENM-NKEKAFLFE 570
E +V + + E+ E SS +I + +E+A L +
Sbjct: 3168 ENALSVAEEQIRRLEHSEWDSSRTPIIGSCGTQEQALLID 3207
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.306 0.122 0.313
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 30,666,526
Number of Sequences: 37866
Number of extensions: 1347079
Number of successful extensions: 27614
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 851
Number of HSP's successfully gapped in prelim test: 1591
Number of HSP's that attempted gapping in prelim test: 8418
Number of HSP's gapped (non-prelim): 9541
length of query: 951
length of database: 18,247,518
effective HSP length: 112
effective length of query: 839
effective length of database: 14,006,526
effective search space: 11751475314
effective search space used: 11751475314
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.6 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.