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Search of human proteins with 115527097
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|115527097 CDC42-binding protein kinase beta [Homo sapiens]
(1711 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|115527097 CDC42-binding protein kinase beta [Homo sapiens] 3405 0.0
gi|30089962 CDC42-binding protein kinase alpha isoform B [Homo s... 2106 0.0
gi|30089960 CDC42-binding protein kinase alpha isoform A [Homo s... 1819 0.0
gi|156766068 CDC42 binding protein kinase gamma (DMPK-like) [Hom... 1254 0.0
gi|126091040 myotonic dystrophy protein kinase isoform 4 [Homo s... 515 e-145
gi|126131093 myotonic dystrophy protein kinase isoform 3 [Homo s... 515 e-145
gi|47059024 myotonic dystrophy protein kinase isoform 2 [Homo sa... 510 e-144
gi|4885583 Rho-associated, coiled-coil containing protein kinase... 484 e-136
gi|41872583 Rho-associated, coiled-coil containing protein kinas... 465 e-130
gi|126091095 myotonic dystrophy protein kinase isoform 1 [Homo s... 462 e-129
gi|32698688 citron [Homo sapiens] 407 e-113
gi|24307971 serine/threonine kinase 38 like [Homo sapiens] 305 3e-82
gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [H... 205 3e-52
gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4 [... 205 3e-52
gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3 [... 205 3e-52
gi|219521876 serum/glucocorticoid regulated kinase 1 isoform 2 [... 205 3e-52
gi|7657526 ribosomal protein S6 kinase polypeptide 6 [Homo sapiens] 205 3e-52
gi|46909584 cAMP-dependent protein kinase catalytic subunit alph... 204 5e-52
gi|4506055 cAMP-dependent protein kinase catalytic subunit alpha... 204 5e-52
gi|4506057 cAMP-dependent protein kinase catalytic subunit beta ... 204 5e-52
gi|33636738 cAMP-dependent protein kinase catalytic subunit beta... 204 5e-52
gi|25168261 serum/glucocorticoid regulated kinase 2 isoform alph... 203 1e-51
gi|20127541 serum/glucocorticoid regulated kinase 2 isoform beta... 203 1e-51
gi|32528297 ribosomal protein S6 kinase, polypeptide 5 isoform b... 202 2e-51
gi|32528295 ribosomal protein S6 kinase, polypeptide 5 isoform a... 202 2e-51
gi|4502023 AKT2 kinase [Homo sapiens] 202 3e-51
gi|62241015 AKT1 kinase [Homo sapiens] 201 5e-51
gi|62241013 AKT1 kinase [Homo sapiens] 201 5e-51
gi|62241011 AKT1 kinase [Homo sapiens] 201 5e-51
gi|5453976 protein kinase C, theta [Homo sapiens] 200 9e-51
>gi|115527097 CDC42-binding protein kinase beta [Homo sapiens]
Length = 1711
Score = 3405 bits (8828), Expect = 0.0
Identities = 1711/1711 (100%), Positives = 1711/1711 (100%)
Query: 1 MSAKVRLKKLEQLLLDGPWRNESALSVETLLDVLVCLYTECSHSALRRDKYVAEFLEWAK 60
MSAKVRLKKLEQLLLDGPWRNESALSVETLLDVLVCLYTECSHSALRRDKYVAEFLEWAK
Sbjct: 1 MSAKVRLKKLEQLLLDGPWRNESALSVETLLDVLVCLYTECSHSALRRDKYVAEFLEWAK 60
Query: 61 PFTQLVKEMQLHREDFEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETAC 120
PFTQLVKEMQLHREDFEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETAC
Sbjct: 61 PFTQLVKEMQLHREDFEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETAC 120
Query: 121 FREERDVLVNGDCQWITALHYAFQDENHLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFY 180
FREERDVLVNGDCQWITALHYAFQDENHLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFY
Sbjct: 121 FREERDVLVNGDCQWITALHYAFQDENHLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFY 180
Query: 181 IGEMVLAIDSIHQLHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVQSSVAVGTP 240
IGEMVLAIDSIHQLHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVQSSVAVGTP
Sbjct: 181 IGEMVLAIDSIHQLHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVQSSVAVGTP 240
Query: 241 DYISPEILQAMEDGMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHEERF 300
DYISPEILQAMEDGMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHEERF
Sbjct: 241 DYISPEILQAMEDGMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHEERF 300
Query: 301 QFPSHVTDVSEEAKDLIQRLICSRERRLGQNGIEDFKKHAFFEGLNWENIRNLEAPYIPD 360
QFPSHVTDVSEEAKDLIQRLICSRERRLGQNGIEDFKKHAFFEGLNWENIRNLEAPYIPD
Sbjct: 301 QFPSHVTDVSEEAKDLIQRLICSRERRLGQNGIEDFKKHAFFEGLNWENIRNLEAPYIPD 360
Query: 361 VSSPSDTSNFDVDDDVLRNTEILPPGSHTGFSGLHLPFIGFTFTTESCFSDRGSLKSIMQ 420
VSSPSDTSNFDVDDDVLRNTEILPPGSHTGFSGLHLPFIGFTFTTESCFSDRGSLKSIMQ
Sbjct: 361 VSSPSDTSNFDVDDDVLRNTEILPPGSHTGFSGLHLPFIGFTFTTESCFSDRGSLKSIMQ 420
Query: 421 SNTLTKDEDVQRDLEHSLQMEAYERRIRRLEQEKLELSRKLQESTQTVQSLHGSSRALSN 480
SNTLTKDEDVQRDLEHSLQMEAYERRIRRLEQEKLELSRKLQESTQTVQSLHGSSRALSN
Sbjct: 421 SNTLTKDEDVQRDLEHSLQMEAYERRIRRLEQEKLELSRKLQESTQTVQSLHGSSRALSN 480
Query: 481 SNRDKEIKKLNEEIERLKNKIADSNRLERQLEDTVALRQEREDSTQRLRGLEKQHRVVRQ 540
SNRDKEIKKLNEEIERLKNKIADSNRLERQLEDTVALRQEREDSTQRLRGLEKQHRVVRQ
Sbjct: 481 SNRDKEIKKLNEEIERLKNKIADSNRLERQLEDTVALRQEREDSTQRLRGLEKQHRVVRQ 540
Query: 541 EKEELHKQLVEASERLKSQAKELKDAHQQRKLALQEFSELNERMAELRAQKQKVSRQLRD 600
EKEELHKQLVEASERLKSQAKELKDAHQQRKLALQEFSELNERMAELRAQKQKVSRQLRD
Sbjct: 541 EKEELHKQLVEASERLKSQAKELKDAHQQRKLALQEFSELNERMAELRAQKQKVSRQLRD 600
Query: 601 KEEEMEVATQKVDAMRQEMRRAEKLRKELEAQLDDAVAEASKERKLREHSENFCKQMESE 660
KEEEMEVATQKVDAMRQEMRRAEKLRKELEAQLDDAVAEASKERKLREHSENFCKQMESE
Sbjct: 601 KEEEMEVATQKVDAMRQEMRRAEKLRKELEAQLDDAVAEASKERKLREHSENFCKQMESE 660
Query: 661 LEALKVKQGGRGAGATLEHQQEISKIKSELEKKVLFYEEELVRREASHVLEVKNVKKEVH 720
LEALKVKQGGRGAGATLEHQQEISKIKSELEKKVLFYEEELVRREASHVLEVKNVKKEVH
Sbjct: 661 LEALKVKQGGRGAGATLEHQQEISKIKSELEKKVLFYEEELVRREASHVLEVKNVKKEVH 720
Query: 721 DSESHQLALQKEILMLKDKLEKSKRERHNEMEEAVGTIKDKYERERAMLFDENKKLTAEN 780
DSESHQLALQKEILMLKDKLEKSKRERHNEMEEAVGTIKDKYERERAMLFDENKKLTAEN
Sbjct: 721 DSESHQLALQKEILMLKDKLEKSKRERHNEMEEAVGTIKDKYERERAMLFDENKKLTAEN 780
Query: 781 EKLCSFVDKLTAQNRQLEDELQDLAAKKESVAHWEAQIAEIIQWVSDEKDARGYLQALAS 840
EKLCSFVDKLTAQNRQLEDELQDLAAKKESVAHWEAQIAEIIQWVSDEKDARGYLQALAS
Sbjct: 781 EKLCSFVDKLTAQNRQLEDELQDLAAKKESVAHWEAQIAEIIQWVSDEKDARGYLQALAS 840
Query: 841 KMTEELEALRSSSLGSRTLDPLWKVRRSQKLDMSARLELQSALEAEIRAKQLVQEELRKV 900
KMTEELEALRSSSLGSRTLDPLWKVRRSQKLDMSARLELQSALEAEIRAKQLVQEELRKV
Sbjct: 841 KMTEELEALRSSSLGSRTLDPLWKVRRSQKLDMSARLELQSALEAEIRAKQLVQEELRKV 900
Query: 901 KDANLTLESKLKDSEAKNRELLEEMEILKKKMEEKFRADTGLKLPDFQDSIFEYFNTAPL 960
KDANLTLESKLKDSEAKNRELLEEMEILKKKMEEKFRADTGLKLPDFQDSIFEYFNTAPL
Sbjct: 901 KDANLTLESKLKDSEAKNRELLEEMEILKKKMEEKFRADTGLKLPDFQDSIFEYFNTAPL 960
Query: 961 AHDLTFRTSSASEQETQAPKPEASPSMSVAASEQQEDMARPPQRPSAVPLPTTQALALAG 1020
AHDLTFRTSSASEQETQAPKPEASPSMSVAASEQQEDMARPPQRPSAVPLPTTQALALAG
Sbjct: 961 AHDLTFRTSSASEQETQAPKPEASPSMSVAASEQQEDMARPPQRPSAVPLPTTQALALAG 1020
Query: 1021 PKPKAHQFSIKSFSSPTQCSHCTSLMVGLIRQGYACEVCSFACHVSCKDGAPQVCPIPPE 1080
PKPKAHQFSIKSFSSPTQCSHCTSLMVGLIRQGYACEVCSFACHVSCKDGAPQVCPIPPE
Sbjct: 1021 PKPKAHQFSIKSFSSPTQCSHCTSLMVGLIRQGYACEVCSFACHVSCKDGAPQVCPIPPE 1080
Query: 1081 QSKRPLGVDVQRGIGTAYKGHVKVPKPTGVKKGWQRAYAVVCDCKLFLYDLPEGKSTQPG 1140
QSKRPLGVDVQRGIGTAYKGHVKVPKPTGVKKGWQRAYAVVCDCKLFLYDLPEGKSTQPG
Sbjct: 1081 QSKRPLGVDVQRGIGTAYKGHVKVPKPTGVKKGWQRAYAVVCDCKLFLYDLPEGKSTQPG 1140
Query: 1141 VIASQVLDLRDDEFSVSSVLASDVIHATRRDIPCIFRVTASLLGAPSKTSSLLILTENEN 1200
VIASQVLDLRDDEFSVSSVLASDVIHATRRDIPCIFRVTASLLGAPSKTSSLLILTENEN
Sbjct: 1141 VIASQVLDLRDDEFSVSSVLASDVIHATRRDIPCIFRVTASLLGAPSKTSSLLILTENEN 1200
Query: 1201 EKRKWVGILEGLQSILHKNRLRNQVVHVPLEAYDSSLPLIKAILTAAIVDADRIAVGLEE 1260
EKRKWVGILEGLQSILHKNRLRNQVVHVPLEAYDSSLPLIKAILTAAIVDADRIAVGLEE
Sbjct: 1201 EKRKWVGILEGLQSILHKNRLRNQVVHVPLEAYDSSLPLIKAILTAAIVDADRIAVGLEE 1260
Query: 1261 GLYVIEVTRDVIVRAADCKKVHQIELAPREKIVILLCGRNHHVHLYPWSSLDGAEGSFDI 1320
GLYVIEVTRDVIVRAADCKKVHQIELAPREKIVILLCGRNHHVHLYPWSSLDGAEGSFDI
Sbjct: 1261 GLYVIEVTRDVIVRAADCKKVHQIELAPREKIVILLCGRNHHVHLYPWSSLDGAEGSFDI 1320
Query: 1321 KLPETKGCQLMATATLKRNSGTCLFVAVKRLILCYEIQRTKPFHRKFNEIVAPGSVQCLA 1380
KLPETKGCQLMATATLKRNSGTCLFVAVKRLILCYEIQRTKPFHRKFNEIVAPGSVQCLA
Sbjct: 1321 KLPETKGCQLMATATLKRNSGTCLFVAVKRLILCYEIQRTKPFHRKFNEIVAPGSVQCLA 1380
Query: 1381 VLRDRLCVGYPSGFCLLSIQGDGQPLNLVNPNDPSLAFLSQQSFDALCAVELESEEYLLC 1440
VLRDRLCVGYPSGFCLLSIQGDGQPLNLVNPNDPSLAFLSQQSFDALCAVELESEEYLLC
Sbjct: 1381 VLRDRLCVGYPSGFCLLSIQGDGQPLNLVNPNDPSLAFLSQQSFDALCAVELESEEYLLC 1440
Query: 1441 FSHMGLYVDPQGRRARAQELMWPAAPVACSCSPTHVTVYSEYGVDVFDVRTMEWVQTIGL 1500
FSHMGLYVDPQGRRARAQELMWPAAPVACSCSPTHVTVYSEYGVDVFDVRTMEWVQTIGL
Sbjct: 1441 FSHMGLYVDPQGRRARAQELMWPAAPVACSCSPTHVTVYSEYGVDVFDVRTMEWVQTIGL 1500
Query: 1501 RRIRPLNSEGTLNLLNCEPPRLIYFKSKFSGAVLNVPDTSDNSKKQMLRTRSKRRFVFKV 1560
RRIRPLNSEGTLNLLNCEPPRLIYFKSKFSGAVLNVPDTSDNSKKQMLRTRSKRRFVFKV
Sbjct: 1501 RRIRPLNSEGTLNLLNCEPPRLIYFKSKFSGAVLNVPDTSDNSKKQMLRTRSKRRFVFKV 1560
Query: 1561 PEEERLQQRREMLRDPELRSKMISNPTNFNHVAHMGPGDGMQVLMDLPLSAVPPSQEERP 1620
PEEERLQQRREMLRDPELRSKMISNPTNFNHVAHMGPGDGMQVLMDLPLSAVPPSQEERP
Sbjct: 1561 PEEERLQQRREMLRDPELRSKMISNPTNFNHVAHMGPGDGMQVLMDLPLSAVPPSQEERP 1620
Query: 1621 GPAPTNLARQPPSRNKPYISWPSSGGSEPSVTVPLRSMSDPDQDFDKEPDSDSTKHSTPS 1680
GPAPTNLARQPPSRNKPYISWPSSGGSEPSVTVPLRSMSDPDQDFDKEPDSDSTKHSTPS
Sbjct: 1621 GPAPTNLARQPPSRNKPYISWPSSGGSEPSVTVPLRSMSDPDQDFDKEPDSDSTKHSTPS 1680
Query: 1681 NSSNPSGPPSPNSPHRSQLPLEGLEQPACDT 1711
NSSNPSGPPSPNSPHRSQLPLEGLEQPACDT
Sbjct: 1681 NSSNPSGPPSPNSPHRSQLPLEGLEQPACDT 1711
>gi|30089962 CDC42-binding protein kinase alpha isoform B [Homo
sapiens]
Length = 1719
Score = 2106 bits (5456), Expect = 0.0
Identities = 1061/1749 (60%), Positives = 1347/1749 (77%), Gaps = 70/1749 (4%)
Query: 1 MSAKVRLKKLEQLLLDGPWR-NESALSVETLLDVLVCLYTECSHSALRRDKYVAEFLEWA 59
MS +VRL++LEQ +LDGP + N SVETLLD+L+CLY EC++S LRR+K + E+LEWA
Sbjct: 1 MSGEVRLRQLEQFILDGPAQTNGQCFSVETLLDILICLYDECNNSPLRREKNILEYLEWA 60
Query: 60 KPFTQLVKEMQLHREDFEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETA 119
KPFT VK+M+LHREDFEI+KVIGRGAFGEVAVVK+KN ++++AMKILNKWEMLKRAETA
Sbjct: 61 KPFTSKVKQMRLHREDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETA 120
Query: 120 CFREERDVLVNGDCQWITALHYAFQDENHLYLVMDYYVGGDLLTLLSKFEDKLPEDMARF 179
CFREERDVLVNGD +WIT LHYAFQD+N+LYLVMDYYVGGDLLTLLSKFED+LPEDMARF
Sbjct: 121 CFREERDVLVNGDNKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMARF 180
Query: 180 YIGEMVLAIDSIHQLHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVQSSVAVGT 239
Y+ EMV+AIDS+HQLHYVHRDIKPDN+L+D+NGHIRLADFGSCLK+ +DGTVQSSVAVGT
Sbjct: 181 YLAEMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGT 240
Query: 240 PDYISPEILQAMEDGMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHEER 299
PDYISPEILQAMEDG G+YGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNH+ER
Sbjct: 241 PDYISPEILQAMEDGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKER 300
Query: 300 FQFPSHVTDVSEEAKDLIQRLICSRERRLGQNGIEDFKKHAFFEGLNWENIRNLEAPYIP 359
FQFP+ VTDVSE AKDLI+RLICSRE RLGQNGIEDFKKH FF G++W+NIRN EAPYIP
Sbjct: 301 FQFPAQVTDVSENAKDLIRRLICSREHRLGQNGIEDFKKHPFFSGIDWDNIRNCEAPYIP 360
Query: 360 DVSSPSDTSNFDVDDDVLRNTEILPPGSHTGFSGLHLPFIGFTFTTESCFSDRGSLKSIM 419
+VSSP+DTSNFDVDDD L+N+E +PP +HT FSG HLPF+GFT+T+ SDR L+
Sbjct: 361 EVSSPTDTSNFDVDDDCLKNSETMPPPTHTAFSGHHLPFVGFTYTSSCVLSDRSCLRVTA 420
Query: 420 QSNTLTKDEDVQRDLEHSLQMEAYERRIRRLEQEKLELSRKLQESTQTVQSLHGSS-RAL 478
+L D +VQR L+++L EAYERRI+RLEQEKLELSRKLQESTQTVQ+L S+
Sbjct: 421 GPTSLDLDVNVQRTLDNNLATEAYERRIKRLEQEKLELSRKLQESTQTVQALQYSTVDGP 480
Query: 479 SNSNRDKEIKKLNEEIERLKNKIADSNRLERQLEDTVALRQEREDSTQRLRGLEKQHRVV 538
+++D EIK L EEIE+L+ ++ +S+ LE+QLE+ A+RQE +D+ ++++ EKQ + +
Sbjct: 481 LTASKDLEIKNLKEEIEKLRKQVTESSHLEQQLEEANAVRQELDDAFRQIKAYEKQIKTL 540
Query: 539 RQEKEELHKQLVEASERLKSQAKELKDAHQQRKLALQEFSELNERMAELRAQKQKVSRQL 598
+QE+E+L+K+LV+ASERLK+Q+KELKDAH QRKLA+QEF E+NER+ EL QKQK++R +
Sbjct: 541 QQEREDLNKELVQASERLKNQSKELKDAHCQRKLAMQEFMEINERLTELHTQKQKLARHV 600
Query: 599 RDKEEEMEVATQKVDAMRQEMRRAEKLRKELEAQLDDAVAEASKERKLREHSENFCKQME 658
RDKEEE+++ QKV+++RQE+RR E+ +KELE + AEASK+RKLRE SE++ KQ+E
Sbjct: 601 RDKEEEVDLVMQKVESLRQELRRTERAKKELEVHTEALAAEASKDRKLREQSEHYSKQLE 660
Query: 659 SELEALKVKQGGRGAG-ATLEHQQEISKIKSELEKKVLFYEEELVRREASHVLEVKNVKK 717
+ELE LK KQ G ++EHQQEI+K+K++LEKK +FYEEEL +RE H E+KN+KK
Sbjct: 661 NELEGLKQKQISYSPGVCSIEHQQEITKLKTDLEKKSIFYEEELSKREGIHANEIKNLKK 720
Query: 718 EVHDSESHQLALQKEILMLKDKLEKSKRERHNEMEEAVGTIKDKYERERAMLFDENKKLT 777
E+HDSE QLAL KEI++LKDKLEK++RE +E EE K +YERE+ +L +ENKKLT
Sbjct: 721 ELHDSEGQQLALNKEIMILKDKLEKTRRESQSEREEFESEFKQQYEREKVLLTEENKKLT 780
Query: 778 AENEKLCSFVDKLTAQNRQLEDELQDLAAKKESVAHWEAQIAEIIQWVSDEKDARGYLQA 837
+E +KL + + L+ N+QLE+E++DLA KKESVAHWEAQI EIIQWVSDEKDARGYLQA
Sbjct: 781 SELDKLTTLYENLSIHNQQLEEEVKDLADKKESVAHWEAQITEIIQWVSDEKDARGYLQA 840
Query: 838 LASKMTEELEALRSSSLGSRTLDPLWKVRRSQKLDMSARLELQSALEAEIRAKQLVQEEL 897
LASKMTEELEALR+SSLG+R D WK+RR KLDMSARLELQSAL+AEIRAKQ +QEEL
Sbjct: 841 LASKMTEELEALRNSSLGTRATDMPWKMRRFAKLDMSARLELQSALDAEIRAKQAIQEEL 900
Query: 898 RKVKDANLTLESKLKDSEAKNRELLEEMEILKKKMEEKFRADTGLKLPDFQDSIFEYFNT 957
KVK +N+ E KLKDSE KN ELL E+E L K EE R++ G++ D Q S + NT
Sbjct: 901 NKVKASNIITECKLKDSEKKNLELLSEIEQLIKDTEE-LRSEKGIEHQDSQHSFLAFLNT 959
Query: 958 APLAHDLTFRTSSASEQETQAPKPEASPSMSVAASEQQEDMARPPQRPSAVPLPTTQALA 1017
A D F T ++ P R P + P
Sbjct: 960 PTDALD-QFETVDSTPLSVHTP------------------TLRKKGCPGSTGFP------ 994
Query: 1018 LAGPKPKAHQFSIKSFSSPTQCSHCTSLMVGLIRQGYACEVCSFACHVSCKDGAPQVCPI 1077
PK K HQF +KSF++PT+C CTSLMVGLIRQG +CEVC F+CH++C + AP CP+
Sbjct: 995 ---PKRKTHQFFVKSFTTPTKCHQCTSLMVGLIRQGCSCEVCGFSCHITCVNKAPTTCPV 1051
Query: 1078 PPEQSKRPLGVDVQRGIGTAYKGHVKVPKPTGVKKGWQRAYAVVCDCKLFLYDLPEGKST 1137
PPEQ+K PLG+D Q+GIGTAY+GHV++PKP GVKKGWQRA A+VCD KLFLYD+ EGK++
Sbjct: 1052 PPEQTKGPLGIDPQKGIGTAYEGHVRIPKPAGVKKGWQRALAIVCDFKLFLYDIAEGKAS 1111
Query: 1138 QPGVIASQVLDLRDDEFSVSSVLASDVIHATRRDIPCIFRVTASLLGAPSKTSSLLILTE 1197
QP V+ SQV+D+RD+EFSVSSVLASDVIHA+R+DIPCIFRVTAS L A + S+L+L +
Sbjct: 1112 QPSVVISQVIDMRDEEFSVSSVLASDVIHASRKDIPCIFRVTASQLSASNNKCSILMLAD 1171
Query: 1198 NENEKRKWVGILEGLQSILHKNRLRNQVVHVPLEAYDSSLPLIKAILTAAIVDADRIAVG 1257
ENEK KWVG+L L IL KN+ R++ V+VP EAYDS+LPLIK AAI+D +RIA+G
Sbjct: 1172 TENEKNKWVGVLSELHKILKKNKFRDRSVYVPKEAYDSTLPLIKTTQAAAIIDHERIALG 1231
Query: 1258 LEEGLYVIEVTRDVIVRAADCKKVHQIELAPREKIVILLCGRNHHVHLYPWSSLDGAEGS 1317
EEGL+V+ VT+D I+R D KK+HQIEL P +++V ++ GRN HV L+P S+LDG E
Sbjct: 1232 NEEGLFVVHVTKDEIIRVGDNKKIHQIELIPNDQLVAVISGRNRHVRLFPMSALDGRETD 1291
Query: 1318 FDIKLPETKGCQLMATATLKRNSGTCLFVAVKRLILCYEIQRTKPFHRKFNEIVAPGSVQ 1377
F KL ETKGCQ + + ++ + TCL VA+KR +LCYE+ ++K HRKF EI P +VQ
Sbjct: 1292 F-YKLSETKGCQTVTSGKVRHGALTCLCVAMKRQVLCYELFQSKTRHRKFKEIQVPYNVQ 1350
Query: 1378 CLAVLRDRLCVGYPSGFCLLSIQGDGQPLNLVNPNDPSLAFLSQQSFDALCAVELESEEY 1437
+A+ ++LCVG+ SGF + G+G P ++++ ND +L+F++ Q DA+CAVE+ S+EY
Sbjct: 1351 WMAIFSEQLCVGFQSGFLRYPLNGEGNPYSMLHSNDHTLSFIAHQPMDAICAVEISSKEY 1410
Query: 1438 LLCFSHMGLYVDPQGRRARAQELMWPAAPVACSCSPTHVTVYSEYGVDVFDVRTMEWVQT 1497
LLCF+ +G+Y D QGRR+R QELMWPA P +C + +++VYSE VD+FDV +MEW+QT
Sbjct: 1411 LLCFNSIGIYTDCQGRRSRQQELMWPANPSSCCYNAPYLSVYSENAVDIFDVNSMEWIQT 1470
Query: 1498 IGLRRIRPLNSEGTLNLLNCEPPRLIYFKSKFS-GAVLNVPDTSDNSKKQMLRT-RSKRR 1555
+ L+++RPLN+EG+LNLL E RLIYFK+K + G L VP+TSDNS+KQM+R +KRR
Sbjct: 1471 LPLKKVRPLNNEGSLNLLGLETIRLIYFKNKMAEGDELVVPETSDNSRKQMVRNINNKRR 1530
Query: 1556 FVFKVPEEERLQQRREMLRDPELRSKMISNPTNFNHVAHMGPGDGMQVLMDLPLS----- 1610
+ F+VPEEER+QQRREMLRDPE+R+K+ISNPTNFNH+AHMGPGDG+Q+L DLP++
Sbjct: 1531 YSFRVPEEERMQQRREMLRDPEMRNKLISNPTNFNHIAHMGPGDGIQILKDLPMNPRPQE 1590
Query: 1611 ---------AVPPSQEERPGP-----APTNLARQPPSRNKPYISWPSSGGSEPSVTVPLR 1656
++P + RP P A + L+ + ++N + SGGS + P+
Sbjct: 1591 SRTVFSGSVSIPSITKSRPEPGRSMSASSGLSARSSAQNGSALKREFSGGSYSAKRQPMP 1650
Query: 1657 SMSD--------------PDQDFDKEPDSDSTKHSTPSNSSNPSGPPSPNSPHRSQ-LPL 1701
S S+ P +DFD E DSDS +HST SNSSN S PPSP SP +++ L L
Sbjct: 1651 SPSEGSLSSGGMDQGSDAPARDFDGE-DSDSPRHSTASNSSNLSSPPSPASPRKTKSLSL 1709
Query: 1702 EGLEQPACD 1710
E ++ + D
Sbjct: 1710 ESTDRGSWD 1718
>gi|30089960 CDC42-binding protein kinase alpha isoform A [Homo
sapiens]
Length = 1638
Score = 1819 bits (4712), Expect = 0.0
Identities = 967/1754 (55%), Positives = 1231/1754 (70%), Gaps = 161/1754 (9%)
Query: 1 MSAKVRLKKLEQLLLDGPWR-NESALSVETLLDVLVCLYTECSHSALRRDKYVAEFLEWA 59
MS +VRL++LEQ +LDGP + N SVETLLD+L+CLY EC++S LRR+K + E+LEWA
Sbjct: 1 MSGEVRLRQLEQFILDGPAQTNGQCFSVETLLDILICLYDECNNSPLRREKNILEYLEWA 60
Query: 60 KPFTQLVKEMQLHREDFEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETA 119
KPFT VK+M+LHREDFEI+KVIGRGAFGEVAVVK+KN ++++AMKILNKWEMLKRAETA
Sbjct: 61 KPFTSKVKQMRLHREDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETA 120
Query: 120 CFREERDVLVNGDCQWITALHYAFQDENHLYLVMDYYVGGDLLTLLSKFEDKLPEDMARF 179
CFREERDVLVNGD +WIT LHYAFQD+N+LYLVMDYYVGGDLLTLLSKFED+LPEDMARF
Sbjct: 121 CFREERDVLVNGDNKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMARF 180
Query: 180 YIGEMVLAIDSIHQLHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVQSSVAVGT 239
Y+ EMV+AIDS+HQLHYVHRDIKPDN+L+D+NGHIRLADFGSCLK+ +DGTVQSSVAVGT
Sbjct: 181 YLAEMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGT 240
Query: 240 PDYISPEILQAMEDGMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHEER 299
PDYISPEILQAMEDG G+YGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNH+ER
Sbjct: 241 PDYISPEILQAMEDGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKER 300
Query: 300 FQFPSHVTDVSEEAKDLIQRLICSRERRLGQNGIEDFKKHAFFEGLNWENIRNLEAPYIP 359
FQFP+ VTDVSE AKDLI+RLICSRE RLGQNGIEDFKKH FF G++W+NIRN EAPYIP
Sbjct: 301 FQFPAQVTDVSENAKDLIRRLICSREHRLGQNGIEDFKKHPFFSGIDWDNIRNCEAPYIP 360
Query: 360 DVSSPSDTSNFDVDDDVLRNTEILPPGSHTGFSGLHLPFIGFTFTTESCFSDRGSLKSIM 419
+VSSP+DTSNFDVDDD L+N+E +PP +HT FSG HLPF+GFT+T+ SDR L+
Sbjct: 361 EVSSPTDTSNFDVDDDCLKNSETMPPPTHTAFSGHHLPFVGFTYTSSCVLSDRSCLRVTA 420
Query: 420 QSNTLTKDEDVQRDLEHSLQMEAYERRIRRLEQEKLELSRKLQESTQTVQSLHGSS-RAL 478
+L D +VQR L+++L EAYERRI+RLEQEKLELSRKLQESTQTVQ+L S+
Sbjct: 421 GPTSLDLDVNVQRTLDNNLATEAYERRIKRLEQEKLELSRKLQESTQTVQALQYSTVDGP 480
Query: 479 SNSNRDKEIKKLNEEIERLKNKIADSNRLERQLEDTVALRQEREDSTQRLRGLEKQHRVV 538
+++D EIK L EEIE+L+ ++ +S+ LE+QLE+ A+RQE +D+ ++++ EKQ + +
Sbjct: 481 LTASKDLEIKNLKEEIEKLRKQVTESSHLEQQLEEANAVRQELDDAFRQIKAYEKQIKTL 540
Query: 539 RQEKEELHKQLVEASERLKSQAKELKDAHQQRKLALQEFSELNERMAELRAQKQKVSRQL 598
+QE+E+L+K V +K+ K LR Q + S+QL
Sbjct: 541 QQEREDLNKLEVHTEALAAEASKDRK----------------------LREQSEHYSKQL 578
Query: 599 RDKEEEMEVATQKVDAMR------QEMRRAEKLRKELEAQLDDAVAEASKERKLREHSEN 652
E E+E QK + + + KL+ +LE + E SK + N
Sbjct: 579 ---ENELEGLKQKQISYSPGVCSIEHQQEITKLKTDLEKKSIFYEEELSKREGIH---AN 632
Query: 653 FCKQMESELEALKVKQGGRGAGATLEHQQEISKIKSELEKKVLFYEEELVRREASHVLEV 712
K ++ EL G L +EI +K +LEK RRE+
Sbjct: 633 EIKNLKKELH--------DSEGQQLALNKEIMILKDKLEK---------TRRESQS---- 671
Query: 713 KNVKKEVHDSESHQLALQKEILMLKDKLEKSKRERHNEMEEAVGTIKDKYERERAMLFDE 772
++E +SE Q ++++L+ + E L E
Sbjct: 672 ---EREEFESEFKQQYEREKVLLTE---------------------------ENKKLTSE 701
Query: 773 NKKLTAENEKLCSFVDKLTAQNRQLEDELQDLAAKKESVAHWEAQIAEIIQWVSDEKDAR 832
KLT E L + N+QLE+E++DLA KKESVAHWEAQI EIIQWVSDEKDAR
Sbjct: 702 LDKLTTLYENL-------SIHNQQLEEEVKDLADKKESVAHWEAQITEIIQWVSDEKDAR 754
Query: 833 GYLQALASKMTEELEALRSSSLGSRTLDPLWKVRRSQKLDMSARLELQSALEAEIRAKQL 892
GYLQALASKMTEELEALR+SSLG+R D WK+RR KLDMSARLELQSAL+AEIRAKQ
Sbjct: 755 GYLQALASKMTEELEALRNSSLGTRATDMPWKMRRFAKLDMSARLELQSALDAEIRAKQA 814
Query: 893 VQEELRKVKDANLTLESKLKDSEAKNRELLEEMEILKKKMEEKFRADTGLKLPDFQDSIF 952
+QEEL KVK +N+ E KLKDSE KN ELL E+E L K EE R++ G++ D Q S
Sbjct: 815 IQEELNKVKASNIITECKLKDSEKKNLELLSEIEQLIKDTEE-LRSEKGIEHQDSQHSFL 873
Query: 953 EYFNTAPLAHDLTFRTSSASEQETQAPKPEASPSMSVAASEQQEDMARPPQRPSAVPLPT 1012
+ NT A D F T ++ P R P + P
Sbjct: 874 AFLNTPTDALD-QFETVDSTPLSVHTP------------------TLRKKGCPGSTGFP- 913
Query: 1013 TQALALAGPKPKAHQFSIKSFSSPTQCSHCTSLMVGLIRQGYACEVCSFACHVSCKDGAP 1072
PK K HQF +KSF++PT+C CTSLMVGLIRQG +CEVC F+CH++C + AP
Sbjct: 914 --------PKRKTHQFFVKSFTTPTKCHQCTSLMVGLIRQGCSCEVCGFSCHITCVNKAP 965
Query: 1073 QVCPIPPEQSKRPLGVDVQRGIGTAYKGHVKVPKPTGVKKGWQRAYAVVCDCKLFLYDLP 1132
CP+PPEQ+K PLG+D Q+GIGTAY+GHV++PKP GVKKGWQRA A+VCD KLFLYD+
Sbjct: 966 TTCPVPPEQTKGPLGIDPQKGIGTAYEGHVRIPKPAGVKKGWQRALAIVCDFKLFLYDIA 1025
Query: 1133 EGKSTQPGVIASQVLDLRDDEFSVSSVLASDVIHATRRDIPCIFRVTASLLGAPSKTSSL 1192
EGK++QP V+ SQV+D+RD+EFSVSSVLASDVIHA+R+DIPCIFRVTAS L A + S+
Sbjct: 1026 EGKASQPSVVISQVIDMRDEEFSVSSVLASDVIHASRKDIPCIFRVTASQLSASNNKCSI 1085
Query: 1193 LILTENENEKRKWVGILEGLQSILHKNRLRNQVVHVPLEAYDSSLPLIKAILTAAIVDAD 1252
L+L + ENEK KWVG+L L IL KN+ R++ V+VP EAYDS+LPLIK AAI+D +
Sbjct: 1086 LMLADTENEKNKWVGVLSELHKILKKNKFRDRSVYVPKEAYDSTLPLIKTTQAAAIIDHE 1145
Query: 1253 RIAVGLEEGLYVIEVTRDVIVRAADCKKVHQIELAPREKIVILLCGRNHHVHLYPWSSLD 1312
RIA+G EEGL+V+ VT+D I+R D KK+HQIEL P +++V ++ GRN HV L+P S+LD
Sbjct: 1146 RIALGNEEGLFVVHVTKDEIIRVGDNKKIHQIELIPNDQLVAVISGRNRHVRLFPMSALD 1205
Query: 1313 GAEGSFDIKLPETKGCQLMATATLKRNSGTCLFVAVKRLILCYEIQRTKPFHRKFNEIVA 1372
G E F KL ETKGCQ + + ++ + TCL VA+KR +LCYE+ ++K HRKF EI
Sbjct: 1206 GRETDF-YKLSETKGCQTVTSGKVRHGALTCLCVAMKRQVLCYELFQSKTRHRKFKEIQV 1264
Query: 1373 PGSVQCLAVLRDRLCVGYPSGFCLLSIQGDGQPLNLVNPNDPSLAFLSQQSFDALCAVEL 1432
P +VQ +A+ ++LCVG+ SGF + G+G P ++++ ND +L+F++ Q DA+CAVE+
Sbjct: 1265 PYNVQWMAIFSEQLCVGFQSGFLRYPLNGEGNPYSMLHSNDHTLSFIAHQPMDAICAVEI 1324
Query: 1433 ESEEYLLCFSHMGLYVDPQGRRARAQELMWPAAPVACSCSPTHVTVYSEYGVDVFDVRTM 1492
S+EYLLCF+ +G+Y D QGRR+R QELMWPA P +C + +++VYSE VD+FDV +M
Sbjct: 1325 SSKEYLLCFNSIGIYTDCQGRRSRQQELMWPANPSSCCYNAPYLSVYSENAVDIFDVNSM 1384
Query: 1493 EWVQTIGLRRIRPLNSEGTLNLLNCEPPRLIYFKSKFS-GAVLNVPDTSDNSKKQMLRT- 1550
EW+QT+ L+++RPLN+EG+LNLL E RLIYFK+K + G L VP+TSDNS+KQM+R
Sbjct: 1385 EWIQTLPLKKVRPLNNEGSLNLLGLETIRLIYFKNKMAEGDELVVPETSDNSRKQMVRNI 1444
Query: 1551 RSKRRFVFKVPEEERLQQRREMLRDPELRSKMISNPTNFNHVAHMGPGDGMQVLMDLPLS 1610
+KRR+ F+VPEEER+QQRREMLRDPE+R+K+ISNPTNFNH+AHMGPGDG+Q+L DLP++
Sbjct: 1445 NNKRRYSFRVPEEERMQQRREMLRDPEMRNKLISNPTNFNHIAHMGPGDGIQILKDLPMN 1504
Query: 1611 --------------AVPPSQEERPGP-----APTNLARQPPSRNKPYISWPSSGGSEPSV 1651
++P + RP P A + L+ + ++N + SGGS +
Sbjct: 1505 PRPQESRTVFSGSVSIPSITKSRPEPGRSMSASSGLSARSSAQNGSALKREFSGGSYSAK 1564
Query: 1652 TVPLRSMSD--------------PDQDFDKEPDSDSTKHSTPSNSSNPSGPPSPNSPHRS 1697
P+ S S+ P +DFD E DSDS +HST SNSSN S PPSP SP ++
Sbjct: 1565 RQPMPSPSEGSLSSGGMDQGSDAPARDFDGE-DSDSPRHSTASNSSNLSSPPSPASPRKT 1623
Query: 1698 Q-LPLEGLEQPACD 1710
+ L LE ++ + D
Sbjct: 1624 KSLSLESTDRGSWD 1637
>gi|156766068 CDC42 binding protein kinase gamma (DMPK-like) [Homo
sapiens]
Length = 1551
Score = 1254 bits (3246), Expect = 0.0
Identities = 717/1655 (43%), Positives = 1004/1655 (60%), Gaps = 174/1655 (10%)
Query: 6 RLKKLEQLLLDGPWRNESA--LSVETLLDVLVCLYTECSHSALRRDKYVAEFLEWAKPFT 63
RL+ LEQL R E+ ++ LLD+L+ L+ E S LRR++ VA+FL WA PF
Sbjct: 4 RLRALEQLA-----RGEAGGCPGLDGLLDLLLALHHELSSGPLRRERSVAQFLSWASPFV 58
Query: 64 QLVKEMQLHREDFEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFRE 123
VKE++L R+DFEI+KVIGRGAFGEV VV+ ++T +I+AMK+L+KWEMLKRAETACFRE
Sbjct: 59 SKVKELRLQRDDFEILKVIGRGAFGEVTVVRQRDTGQIFAMKMLHKWEMLKRAETACFRE 118
Query: 124 ERDVLVNGDCQWITALHYAFQDENHLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFYIGE 183
ERDVLV GD +W+T LHYAFQDE +LYLVMDYY GGDLLTLLS+FED+LP ++A+FY+ E
Sbjct: 119 ERDVLVKGDSRWVTTLHYAFQDEEYLYLVMDYYAGGDLLTLLSRFEDRLPPELAQFYLAE 178
Query: 184 MVLAIDSIHQLHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVQSSVAVGTPDYI 243
MVLAI S+HQL YVHRD+KPDNVLLDVNGHIRLADFGSCL++N +G V SSVAVGTPDYI
Sbjct: 179 MVLAIHSLHQLGYVHRDVKPDNVLLDVNGHIRLADFGSCLRLNTNGMVDSSVAVGTPDYI 238
Query: 244 SPEILQAMEDGMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHEERFQFP 303
SPEILQAME+G G YGP+CDWWSLGVC YE+L+GETPFYAESLVETYGKIMNHE+ QFP
Sbjct: 239 SPEILQAMEEGKGHYGPQCDWWSLGVCAYELLFGETPFYAESLVETYGKIMNHEDHLQFP 298
Query: 304 SHVTDVSEEAKDLIQRLICSRERRLGQNGIEDFKKHAFFEGLNWENIRNLEAPYIPDVSS 363
V DV A+DLI++L+C +E RLG+ G++DF+ H FFEG++WE + + APYIP++
Sbjct: 299 PDVPDVPASAQDLIRQLLCRQEERLGRGGLDDFRNHPFFEGVDWERLASSTAPYIPELRG 358
Query: 364 PSDTSNFDVDDDVLRNTEILPPGSHTGFSGLHLPFIGFTFTTESCFSDRGSLKSIMQSNT 423
P DTSNFDVDDD L + LPP SH FSG HLPF+GFT+T+ S +
Sbjct: 359 PMDTSNFDVDDDTLNHPGTLPPPSHGAFSGHHLPFVGFTYTSGSHSPE------------ 406
Query: 424 LTKDEDVQRDLEHSLQMEAYERRIRRLEQEKLELSRKLQESTQTVQSLHGSSRALSNSNR 483
S A ER+++ LEQEK+ELSRK QE AL
Sbjct: 407 -----------SSSEAWAALERKLQCLEQEKVELSRKHQE-------------ALHAPTD 442
Query: 484 DKEIKKLNEEIERLKNKIADSNRLERQLEDTVALRQEREDSTQRLRGLEKQHRVVRQEKE 543
+E+++L +E++ L+ +RL L D +L Q G Q +RQE +
Sbjct: 443 HRELEQLRKEVQTLR------DRLPEMLRDKASLSQTDGPPA----GSPGQDSDLRQELD 492
Query: 544 ELHKQLVEASERLKSQAKELKDAHQQRKLALQEFSELNERMAELRAQKQKVSRQLRDKEE 603
LH++L E L++Q +EL A Q++ LQ E ER A +Q + +S QL E
Sbjct: 493 RLHRELAEGRAGLQAQEQELCRAQGQQEELLQRLQEAQEREAATASQTRALSSQL----E 548
Query: 604 EMEVATQKVDAMRQEMRRAEKLRKELEAQLDDAVAEASKERKLREHSENFCKQMESELEA 663
E A ++++A + R +L+ Q + + E+S+ + + SE
Sbjct: 549 EARAAQRELEAQVSSLSRQV---TQLQGQWEQRLEESSQAKTIHTASET----------- 594
Query: 664 LKVKQGGRGAGATLEHQQEISKIKSELEKKVLFYEEELVRREASHVLEVKNVKKEVHDSE 723
G G QE ++L K+V E+L
Sbjct: 595 -------NGMGPPEGGPQE-----AQLRKEVAALREQL---------------------- 620
Query: 724 SHQLALQKEILMLKDKLEKSKRERHNEMEEAVGTIKDKYERERAMLFDENKKLTAENEKL 783
E++ R + EEA+ +++ EN++L+ E E+L
Sbjct: 621 -----------------EQAHSHRPSGKEEALCQLQE-----------ENRRLSREQERL 652
Query: 784 CSFVDKLTAQNRQLEDELQDLAAKKESVAHWEAQIAEIIQWVSDEKDARGYLQALASKMT 843
+ + + ++LE E ++E+ ++WEAQ+A+I+ WV+DEK +RGYLQALA+KM
Sbjct: 653 EAELAQEQESKQRLEGE------RRETESNWEAQLADILSWVNDEKVSRGYLQALATKMA 706
Query: 844 EELEALR---SSSLGSRTLDPLWKVRRSQKLDMSARLELQSALEAEIRAKQLVQEELRKV 900
EELE+LR + +L +R LD WK RR QK++ SARLELQSALEAEIRAKQ +QE L +V
Sbjct: 707 EELESLRNVGTQTLPARPLDHQWKARRLQKMEASARLELQSALEAEIRAKQGLQERLTQV 766
Query: 901 KDANLTLESKLKDSEAKNRELLEEMEILKKKMEEKFRADTGLKLPDFQDSIFEYFNTAPL 960
++A L E +L+++E +++ L +E+ +L++++ + DT +S+ + +
Sbjct: 767 QEAQLQAERRLQEAEKQSQALQQELAMLREELRARGPVDT-----KPSNSLIPFLSFRSS 821
Query: 961 AHDLTFRTSSASEQETQAPKPEASPSMSVAASEQQEDMARPPQRPSAVPLPTTQALALAG 1020
D + E +P+ P E + + P A P T +
Sbjct: 822 EKDSAKDPGISGEATRHGGEPDLRP-------EGRRSLRMGAVFPRA-PTANTASTEGLP 873
Query: 1021 PKPKAHQFSIKSFSSPTQCSHCTSLMVGLIRQGYACEVCSFACHVSCKDGAPQVCPIPPE 1080
KP +H +SF SPT+C CTSLM+GL RQG C+ C + CH +C AP CP+PP+
Sbjct: 874 AKPGSHTLRPRSFPSPTKCLRCTSLMLGLGRQGLGCDACGYFCHTTCAPQAPP-CPVPPD 932
Query: 1081 QSKRPLGVDVQRGIGTAYKGHVKVPKPTGVKKGWQRAYAVVCDCKLFLYDLPEGKSTQPG 1140
+ LGV + G GTAY+G + VP+P+GV++GWQR +A + D +L L+D P+ + + P
Sbjct: 933 LLRTALGVHPETGTGTAYEGFLSVPRPSGVRRGWQRVFAALSDSRLLLFDAPDLRLSPPS 992
Query: 1141 VIASQVLDLRDDEFSVSSVLASDVIHATRRDIPCIFRVTASLLGAPSKTSSLLILTENEN 1200
QVLDLRD +FS + VLASDVIHA RD+P IFRVT S L P T ++L+L E+E
Sbjct: 993 GALLQVLDLRDPQFSATPVLASDVIHAQSRDLPRIFRVTTSQLAVPPTTCTVLLLAESEG 1052
Query: 1201 EKRKWVGILEGLQSILHKNRLRNQVVHVPLEAYDSSLPLIKAILTAAIVDADRIAVGLEE 1260
E+ +W+ +L LQ +L R R + V+ EAYD+ LPL+ L AAI+D DR+A+G EE
Sbjct: 1053 ERERWLQVLGELQRLLLDARPRPRPVYTLKEAYDNGLPLLPHTLCAAILDQDRLALGTEE 1112
Query: 1261 GLYVIEVTRDVIVRAADCKKVHQIELAPREKIVILLCGRNHHVHLYPWSSLDGAEGSFDI 1320
GL+VI + + I + +C++V Q+ L+P ++++LCGR V L+ + L+ E +
Sbjct: 1113 GLFVIHLRSNDIFQVGECRRVQQLTLSPSAGLLVVLCGRGPSVRLFALAELENIEVA-GA 1171
Query: 1321 KLPETKGCQLMATATLKRNSGTCLFVAVKRLILCYEI-QRTKPFHRKFNEIVAPGSVQCL 1379
K+PE++GCQ++A ++ + L VAVKR +LCY++ P+ R+ E+ AP +VQ L
Sbjct: 1172 KIPESRGCQVLAAGSILQARTPVLCVAVKRQVLCYQLGPGPGPWQRRIRELQAPATVQSL 1231
Query: 1380 AVLRDRLCVGYPSGFCLLSIQGDGQPLNL---VNPND--PSLAFLSQQSFDALCAVELES 1434
+L DRLCVG GF L + + PL L + P + PS L +AL AVEL
Sbjct: 1232 GLLGDRLCVGAAGGFALYPLLNEAAPLALGAGLVPEELPPSRGGLG----EALGAVELSL 1287
Query: 1435 EEYLLCFSHMGLYVDPQGRRARAQELMWPAAPVACSCSPTHVTVYSEYGVDVFDVRTMEW 1494
E+LL F+ G+YVD GR++R EL+WPAAP+ + ++TV+SE +DVFDVR EW
Sbjct: 1288 SEFLLLFTTAGIYVDGAGRKSRGHELLWPAAPMGWGYAAPYLTVFSENSIDVFDVRRAEW 1347
Query: 1495 VQTIGLRRIRPLNSEGTLNLLNCEPPRLIYFKSKFSGA-VLNVPDTSDNSKKQMLRTRSK 1553
VQT+ L+++RPLN EG+L L E RL Y +++ + ++PD +DNS++Q+ RT+SK
Sbjct: 1348 VQTVPLKKVRPLNPEGSLFLYGTEKVRLTYLRNQLAEKDEFDIPDLTDNSRRQLFRTKSK 1407
Query: 1554 RRFVFKVPEEERLQQRREMLRDPELRSKMISNPTNFNHVAHMGPGDGMQVLMDLPLSAVP 1613
RRF F+V EE++ QQRREML+DP +RSK+IS PTNFNH+ H+GP +G D
Sbjct: 1408 RRFFFRVSEEQQKQQRREMLKDPFVRSKLISPPTNFNHLVHVGPANGRPGARD-----KS 1462
Query: 1614 PSQEERPGPAPTNLARQPPSRNKPYISWPSSGGSE 1648
P+ EE+ G Q P + P+S GSE
Sbjct: 1463 PAPEEK-GRVARGSGPQRPHSFSEALRRPASMGSE 1496
>gi|126091040 myotonic dystrophy protein kinase isoform 4 [Homo
sapiens]
Length = 625
Score = 515 bits (1326), Expect = e-145
Identities = 278/561 (49%), Positives = 376/561 (67%), Gaps = 38/561 (6%)
Query: 1 MSAKVRLKKLEQLLLDGPWRNESALSVETLLDVLVCLYTECSHSALRRDKYVAEFLEWAK 60
MSA+VRL++L+QL+LD + L +E LLD+L+ ++ E S L +DKYVA+FL+WA+
Sbjct: 1 MSAEVRLRRLQQLVLDPGF-----LGLEPLLDLLLGVHQELGASELAQDKYVADFLQWAE 55
Query: 61 PFTQLVKEMQLHREDFEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETAC 120
P +KE++L R+DFEI+KVIGRGAF EVAVVKMK T ++YAMKI+NKW+MLKR E +C
Sbjct: 56 PIVVRLKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSC 115
Query: 121 FREERDVLVNGDCQWITALHYAFQDENHLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFY 180
FREERDVLVNGD +WIT LH+AFQDEN+LYLVM+YYVGGDLLTLLSKF +++P +MARFY
Sbjct: 116 FREERDVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFY 175
Query: 181 IGEMVLAIDSIHQLHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVQSSVAVGTP 240
+ E+V+AIDS+H+L YVHRDIKPDN+LLD GHIRLADFGSCLK+ DGTV+S VAVGTP
Sbjct: 176 LAEIVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTP 235
Query: 241 DYISPEILQAM--EDGMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHEE 298
DY+SPEILQA+ G G YGPECDWW+LGV YEM YG+TPFYA+S ETYGKI++++E
Sbjct: 236 DYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYKE 295
Query: 299 RFQFPSHVTDVSEEAKDLIQRLICSRERRLGQNGIEDFKKHAFFEGLNWENIRNLEAPYI 358
P V EEA+D IQRL+C E RLG+ G DF+ H FF GL+W+ +R+ P+
Sbjct: 296 HLSLPLVDEGVPEEARDFIQRLLCPPETRLGRGGAGDFRTHPFFFGLDWDGLRDSVPPFT 355
Query: 359 PDVSSPSDTSNFDVDDDVLRNTEILPPGSHTGFSGLHLPFIGFTFTTESCFSDRGSLKSI 418
PD +DT NFD+ +D L E L G+HLPF+G+++ SC +
Sbjct: 356 PDFEGATDTCNFDLVEDGLTAMETLSDIREGAPLGVHLPFVGYSY---SCMA-------- 404
Query: 419 MQSNTLTKDEDVQRDLEHSLQMEAYERRIRRLEQEKLELSRKLQESTQTVQSLHGSSRAL 478
+D +V +++EA + ++ LE S Q+ T V A+
Sbjct: 405 ------LRDSEVPGPT--PMELEAEQLLEPHVQAPSLEPSVSPQDETAEV----AVPAAV 452
Query: 479 SNSNRDKEIKKLNEEIERLKNKIADSNRLERQLEDTVALRQEREDSTQRLRGLEKQHRVV 538
+ + E+ L E E L+ ++ L R++E A+R + ++ +LR E ++R
Sbjct: 453 PAAEAEAEV-TLRELQEALEEEVLTRQSLSREME---AIRTDNQNFASQLREAEARNR-- 506
Query: 539 RQEKEELHKQLVEASERLKSQ 559
+ E +QL E E L+++
Sbjct: 507 --DLEAHVRQLQERMELLQAE 525
Score = 45.4 bits (106), Expect = 5e-04
Identities = 26/76 (34%), Positives = 43/76 (56%), Gaps = 4/76 (5%)
Query: 878 ELQSALEAEIRAKQLVQEELRKVKDANLTLESKLKDSEAKNRELLEEMEILKKKME---- 933
ELQ ALE E+ +Q + E+ ++ N S+L+++EA+NR+L + L+++ME
Sbjct: 465 ELQEALEEEVLTRQSLSREMEAIRTDNQNFASQLREAEARNRDLEAHVRQLQERMELLQA 524
Query: 934 EKFRADTGLKLPDFQD 949
E A TG+ P D
Sbjct: 525 EGATAVTGVPSPRATD 540
>gi|126131093 myotonic dystrophy protein kinase isoform 3 [Homo
sapiens]
Length = 624
Score = 515 bits (1326), Expect = e-145
Identities = 278/561 (49%), Positives = 376/561 (67%), Gaps = 38/561 (6%)
Query: 1 MSAKVRLKKLEQLLLDGPWRNESALSVETLLDVLVCLYTECSHSALRRDKYVAEFLEWAK 60
MSA+VRL++L+QL+LD + L +E LLD+L+ ++ E S L +DKYVA+FL+WA+
Sbjct: 1 MSAEVRLRRLQQLVLDPGF-----LGLEPLLDLLLGVHQELGASELAQDKYVADFLQWAE 55
Query: 61 PFTQLVKEMQLHREDFEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETAC 120
P +KE++L R+DFEI+KVIGRGAF EVAVVKMK T ++YAMKI+NKW+MLKR E +C
Sbjct: 56 PIVVRLKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSC 115
Query: 121 FREERDVLVNGDCQWITALHYAFQDENHLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFY 180
FREERDVLVNGD +WIT LH+AFQDEN+LYLVM+YYVGGDLLTLLSKF +++P +MARFY
Sbjct: 116 FREERDVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFY 175
Query: 181 IGEMVLAIDSIHQLHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVQSSVAVGTP 240
+ E+V+AIDS+H+L YVHRDIKPDN+LLD GHIRLADFGSCLK+ DGTV+S VAVGTP
Sbjct: 176 LAEIVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTP 235
Query: 241 DYISPEILQAM--EDGMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHEE 298
DY+SPEILQA+ G G YGPECDWW+LGV YEM YG+TPFYA+S ETYGKI++++E
Sbjct: 236 DYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYKE 295
Query: 299 RFQFPSHVTDVSEEAKDLIQRLICSRERRLGQNGIEDFKKHAFFEGLNWENIRNLEAPYI 358
P V EEA+D IQRL+C E RLG+ G DF+ H FF GL+W+ +R+ P+
Sbjct: 296 HLSLPLVDEGVPEEARDFIQRLLCPPETRLGRGGAGDFRTHPFFFGLDWDGLRDSVPPFT 355
Query: 359 PDVSSPSDTSNFDVDDDVLRNTEILPPGSHTGFSGLHLPFIGFTFTTESCFSDRGSLKSI 418
PD +DT NFD+ +D L E L G+HLPF+G+++ SC +
Sbjct: 356 PDFEGATDTCNFDLVEDGLTAMETLSDIREGAPLGVHLPFVGYSY---SCMA-------- 404
Query: 419 MQSNTLTKDEDVQRDLEHSLQMEAYERRIRRLEQEKLELSRKLQESTQTVQSLHGSSRAL 478
+D +V +++EA + ++ LE S Q+ T V A+
Sbjct: 405 ------LRDSEVPGPT--PMELEAEQLLEPHVQAPSLEPSVSPQDETAEV----AVPAAV 452
Query: 479 SNSNRDKEIKKLNEEIERLKNKIADSNRLERQLEDTVALRQEREDSTQRLRGLEKQHRVV 538
+ + E+ L E E L+ ++ L R++E A+R + ++ +LR E ++R
Sbjct: 453 PAAEAEAEV-TLRELQEALEEEVLTRQSLSREME---AIRTDNQNFASQLREAEARNR-- 506
Query: 539 RQEKEELHKQLVEASERLKSQ 559
+ E +QL E E L+++
Sbjct: 507 --DLEAHVRQLQERMELLQAE 525
Score = 45.4 bits (106), Expect = 5e-04
Identities = 26/76 (34%), Positives = 43/76 (56%), Gaps = 4/76 (5%)
Query: 878 ELQSALEAEIRAKQLVQEELRKVKDANLTLESKLKDSEAKNRELLEEMEILKKKME---- 933
ELQ ALE E+ +Q + E+ ++ N S+L+++EA+NR+L + L+++ME
Sbjct: 465 ELQEALEEEVLTRQSLSREMEAIRTDNQNFASQLREAEARNRDLEAHVRQLQERMELLQA 524
Query: 934 EKFRADTGLKLPDFQD 949
E A TG+ P D
Sbjct: 525 EGATAVTGVPSPRATD 540
>gi|47059024 myotonic dystrophy protein kinase isoform 2 [Homo
sapiens]
Length = 629
Score = 510 bits (1314), Expect = e-144
Identities = 279/568 (49%), Positives = 379/568 (66%), Gaps = 47/568 (8%)
Query: 1 MSAKVRLKKLEQLLLDGPWRNESALSVETLLDVLVCLYTECSHSALRRDKYVAEFLEWAK 60
MSA+VRL++L+QL+LD + L +E LLD+L+ ++ E S L +DKYVA+FL+WA+
Sbjct: 1 MSAEVRLRRLQQLVLDPGF-----LGLEPLLDLLLGVHQELGASELAQDKYVADFLQWAE 55
Query: 61 PFTQLVKEMQLHREDFEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETAC 120
P +KE++L R+DFEI+KVIGRGAF EVAVVKMK T ++YAMKI+NKW+MLKR E +C
Sbjct: 56 PIVVRLKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSC 115
Query: 121 FREERDVLVNGDCQWITALHYAFQDENHLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFY 180
FREERDVLVNGD +WIT LH+AFQDEN+LYLVM+YYVGGDLLTLLSKF +++P +MARFY
Sbjct: 116 FREERDVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFY 175
Query: 181 IGEMVLAIDSIHQLHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVQSSVAVGTP 240
+ E+V+AIDS+H+L YVHRDIKPDN+LLD GHIRLADFGSCLK+ DGTV+S VAVGTP
Sbjct: 176 LAEIVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTP 235
Query: 241 DYISPEILQAM--EDGMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHEE 298
DY+SPEILQA+ G G YGPECDWW+LGV YEM YG+TPFYA+S ETYGKI++++E
Sbjct: 236 DYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYKE 295
Query: 299 RFQFPSHVTDVSEEAKDLIQRLICSRERRLGQNGIEDFKKHAFFEGLNWENIRNLEAPYI 358
P V EEA+D IQRL+C E RLG+ G DF+ H FF GL+W+ +R+ P+
Sbjct: 296 HLSLPLVDEGVPEEARDFIQRLLCPPETRLGRGGAGDFRTHPFFFGLDWDGLRDSVPPFT 355
Query: 359 PDVSSPSDTSNFDVDDDVLRNTEILPPGSHT-------GFSGLHLPFIGFTFTTESCFSD 411
PD +DT NFD+ +D L T ++ G T G+HLPF+G+++ SC +
Sbjct: 356 PDFEGATDTCNFDLVEDGL--TAMVSGGGETLSDIREGAPLGVHLPFVGYSY---SCMA- 409
Query: 412 RGSLKSIMQSNTLTKDEDVQRDLEHSLQMEAYERRIRRLEQEKLELSRKLQESTQTVQSL 471
+D +V +++EA + ++ LE S Q+ T V
Sbjct: 410 -------------LRDSEVPGPT--PMELEAEQLLEPHVQAPSLEPSVSPQDETAEV--- 451
Query: 472 HGSSRALSNSNRDKEIKKLNEEIERLKNKIADSNRLERQLEDTVALRQEREDSTQRLRGL 531
A+ + + E+ L E E L+ ++ L R++E A+R + ++ +LR
Sbjct: 452 -AVPAAVPAAEAEAEV-TLRELQEALEEEVLTRQSLSREME---AIRTDNQNFASQLREA 506
Query: 532 EKQHRVVRQEKEELHKQLVEASERLKSQ 559
E ++R + E +QL E E L+++
Sbjct: 507 EARNR----DLEAHVRQLQERMELLQAE 530
Score = 45.4 bits (106), Expect = 5e-04
Identities = 26/76 (34%), Positives = 43/76 (56%), Gaps = 4/76 (5%)
Query: 878 ELQSALEAEIRAKQLVQEELRKVKDANLTLESKLKDSEAKNRELLEEMEILKKKME---- 933
ELQ ALE E+ +Q + E+ ++ N S+L+++EA+NR+L + L+++ME
Sbjct: 470 ELQEALEEEVLTRQSLSREMEAIRTDNQNFASQLREAEARNRDLEAHVRQLQERMELLQA 529
Query: 934 EKFRADTGLKLPDFQD 949
E A TG+ P D
Sbjct: 530 EGATAVTGVPSPRATD 545
>gi|4885583 Rho-associated, coiled-coil containing protein kinase 1
[Homo sapiens]
Length = 1354
Score = 484 bits (1247), Expect = e-136
Identities = 373/1280 (29%), Positives = 643/1280 (50%), Gaps = 190/1280 (14%)
Query: 2 SAKVRLKKLEQLLLDGPWRNESALSVETLLDVLVCLYTECSHSALRRDKYVAEFLEWAKP 61
S + R +K++ LL D +S ++ + LLD L L + ALR++K + FL K
Sbjct: 6 SFETRFEKMDNLLRDP----KSEVNSDCLLDGLDALVYDLDFPALRKNKNIDNFLSRYKD 61
Query: 62 FTQLVKEMQLHREDFEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACF 121
++++++ ED+E++KVIGRGAFGEV +V+ K+T ++YAMK+L+K+EM+KR+++A F
Sbjct: 62 TINKIRDLRMKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFF 121
Query: 122 REERDVLVNGDCQWITALHYAFQDENHLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFYI 181
EERD++ + W+ L YAFQD+ +LY+VM+Y GGDL+ L+S ++ +PE ARFY
Sbjct: 122 WEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYD--VPEKWARFYT 179
Query: 182 GEMVLAIDSIHQLHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVQSSVAVGTPD 241
E+VLA+D+IH + ++HRD+KPDN+LLD +GH++LADFG+C+KMN +G V+ AVGTPD
Sbjct: 180 AEVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPD 239
Query: 242 YISPEILQAMEDGMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHEERFQ 301
YISPE+L++ + G G YG ECDWWS+GV +YEML G+TPFYA+SLV TY KIMNH+
Sbjct: 240 YISPEVLKS-QGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLT 298
Query: 302 FPSHVTDVSEEAKDLIQRLICSRERRLGQNGIEDFKKHAFFEGLNW--ENIRNLEAPYIP 359
FP D+S+EAK+LI + RE RLG+NG+E+ K+H FF+ W E +R+ AP +P
Sbjct: 299 FPDD-NDISKEAKNLICAFLTDREVRLGRNGVEEIKRHLFFKNDQWAWETLRDTVAPVVP 357
Query: 360 DVSSPSDTSNFDVDDDVLRNTEILPPGSHTGFSGLHLPFIGFTFTTESCFSDRGSLKSIM 419
D+SS DTSNFD ++ E P F G LPF+GFT+ +S+R L S
Sbjct: 358 DLSSDIDTSNFDDLEEDKGEEETFPIPK--AFVGNQLPFVGFTY-----YSNRRYLSSAN 410
Query: 420 QSNTLTKDEDVQRDLEHSLQMEAYERRIRRLEQEKLELSRKLQESTQTVQSLHGSSRALS 479
++ T + + L+ SLQ Y ++ +++L ++++ +T S
Sbjct: 411 PNDNRTSS-NADKSLQESLQKTIY--KLEEQLHNEMQLKDEMEQKCRT-----------S 456
Query: 480 NSNRDKEIKKLNEEIERLKNKIADSNRLERQLEDTVALRQEREDSTQRLRGLEKQHRVVR 539
N DK +K+L+EE + +N LE TV+ + E+E + R E Q +
Sbjct: 457 NIKLDKIMKELDEEGNQRRN-----------LESTVS-QIEKEKMLLQHRINEYQRKA-- 502
Query: 540 QEKEELHKQLVEASERLKSQAKELKDAHQQRKLALQEFSELNERMAE----LRAQKQKVS 595
+++ E + + LK Q ++LK Q +LA ++ S+L +++ E LR +
Sbjct: 503 EQENEKRRNVENEVSTLKDQLEDLKKVSQNSQLANEKLSQLQKQLEEANDLLRTESDTAV 562
Query: 596 RQLRDKEEEMEVATQKVDAMRQEMRRAEKLRKELEAQLD------DAVAEASKERKLREH 649
R LR EM + +++++ +E++ ++ + ++Q D A+ EA ER+ R H
Sbjct: 563 R-LRKSHTEMSKSISQLESLNRELQERNRILENSKSQTDKDYYQLQAILEA--ERRDRGH 619
Query: 650 SENFCKQMESELEAL------------KVKQGGRGAGATLEHQQE------------ISK 685
+++ + +L KV+ + A L H ++ +
Sbjct: 620 DSEMIGDLQARITSLQEEVKHLKHNLEKVEGERKEAQDMLNHSEKEKNNLEIDLNYKLKS 679
Query: 686 IKSELEKKVLFYEEELVRREASH--VLEVKNV------KKEVHDSESHQLA------LQK 731
++ LE++V ++ R H + E K+V KK + E+ + A ++K
Sbjct: 680 LQQRLEQEVNEHKVTKARLTDKHQSIEEAKSVAMCEMEKKLKEEREAREKAENRVVQIEK 739
Query: 732 EILMLKDKLEKSKRERHN------EMEEAVGTIKDKYERERAMLFDENKKLTAENE-KLC 784
+ ML L++S+++ + ME+ V + + E+E NK+L +NE K
Sbjct: 740 QCSMLDVDLKQSQQKLEHLTGNKERMEDEVKNLTLQLEQE------SNKRLLLQNELKTQ 793
Query: 785 SF-VDKLTAQNRQLEDELQDLAAKKESVAHWEAQIAEI-------IQWVSDEKDARGYLQ 836
+F D L +Q++ E+ L K + AQ+ + ++ + D+ +A Y
Sbjct: 794 AFEADNLKGLEKQMKQEINTLLEAKRLLEFELAQLTKQYRGNEGQMRELQDQLEAEQYFS 853
Query: 837 ALASKMTEELEALRSSSLGSRTLDPLWKVR--RSQKLDMSARLEL-QSALEAEIRAKQLV 893
L +EL+ + + + L K++ +++K ++ +L+L ++ E+E A+ L+
Sbjct: 854 TLYKTQVKELK----EEIEEKNRENLKKIQELQNEKETLATQLDLAETKAESEQLARGLL 909
Query: 894 QEE-------------------------LRKVKDANLTLESKLKDSEAKNRELLEEMEIL 928
+E+ + ++++AN L ++ +N EL E+M
Sbjct: 910 EEQYFELTQESKKAASRNRQEITDKDHTVSRLEEANSMLTKDIEILRRENEELTEKM--- 966
Query: 929 KKKMEEKFRADTGLKLPDFQDSIFEYFNTAPLAHDLTFRTSSASEQETQAPKPEASPSMS 988
KK EE+++ + ++ + + + + NT + T +T + ++ + +
Sbjct: 967 -KKAEEEYKLEKEEEISNLKAAFEKNINT-----ERTLKTQAVNKLAEIMNRKDFKIDRK 1020
Query: 989 VAASEQQEDMARPPQRPSAVPLPTTQALALAGPKPKAHQFSIKSFSSPT--QCSHCTSLM 1046
A ++ D+ + + + L Q HQ + + +C+H L
Sbjct: 1021 KANTQ---DLRKKEKENRKLQLELNQEREKFNQMVVKHQKELNDMQAQLVEECAHRNELQ 1077
Query: 1047 VGLIRQGYACEVC-------SFACHVSCKDGAPQVCPIPPEQSKRPLGVDVQRGIGTAYK 1099
+ L + E S + V+ A + PE + +
Sbjct: 1078 MQLASKESDIEQLRAKLLDLSDSTSVASFPSADETDGNLPE---------------SRIE 1122
Query: 1100 GHVKVPKPTGVKK-GWQRAYAVVCDCKLFLYDLPEGKSTQPGVIASQVLDLRDDEFSVSS 1158
G + VP +K+ GW++ Y VV K+ Y+ + K S VLD+ D F V
Sbjct: 1123 GWLSVPNRGNIKRYGWKKQYVVVSSKKILFYNDEQDKEQSN---PSMVLDI-DKLFHVRP 1178
Query: 1159 VLASDVIHATRRDIPCIFRV 1178
V DV A +IP IF++
Sbjct: 1179 VTQGDVYRAETEEIPKIFQI 1198
>gi|41872583 Rho-associated, coiled-coil containing protein kinase 2
[Homo sapiens]
Length = 1388
Score = 465 bits (1196), Expect = e-130
Identities = 329/1042 (31%), Positives = 555/1042 (53%), Gaps = 96/1042 (9%)
Query: 6 RLKKLEQLLLDGPWRNESALSVETLLDVLVCLYTECSHSALRRDKYVAEFLEWAKPFTQL 65
R +KLE L+ D S ++VE+LLD L L + ALR++K + FL + +
Sbjct: 26 RQRKLEALIRDP----RSPINVESLLDGLNSLVLDLDFPALRKNKNIDNFLNRYEKIVKK 81
Query: 66 VKEMQLHREDFEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFREER 125
++ +Q+ ED++++KVIGRGAFGEV +V+ K ++++YAMK+L+K+EM+KR+++A F EER
Sbjct: 82 IRGLQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEER 141
Query: 126 DVLVNGDCQWITALHYAFQDENHLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFYIGEMV 185
D++ + W+ L YAFQD+ +LY+VM+Y GGDL+ L+S ++ +PE A+FY E+V
Sbjct: 142 DIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYD--VPEKWAKFYTAEVV 199
Query: 186 LAIDSIHQLHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVQSSVAVGTPDYISP 245
LA+D+IH + +HRD+KPDN+LLD +GH++LADFG+C+KM++ G V AVGTPDYISP
Sbjct: 200 LALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISP 259
Query: 246 EILQAMEDGMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHEERFQFPSH 305
E+L++ + G G YG ECDWWS+GV +YEML G+TPFYA+SLV TY KIM+H+ FP
Sbjct: 260 EVLKS-QGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKNSLCFPED 318
Query: 306 VTDVSEEAKDLIQRLICSRERRLGQNGIEDFKKHAFFEG--LNWENIRNLEAPYIPDVSS 363
++S+ AK+LI + RE RLG+NG+E+ ++H FF+ +W+NIR AP +P++SS
Sbjct: 319 -AEISKHAKNLICAFLTDREVRLGRNGVEEIRQHPFFKNDQWHWDNIRETAAPVVPELSS 377
Query: 364 PSDTSNFDVDDDVLRNTEILPPGSHTGFSGLHLPFIGFTFTTES-CFSDRGSLKSI--MQ 420
D+SNFD +D + E P F G LPFIGFT+ E+ SD S + +Q
Sbjct: 378 DIDSSNFDDIEDDKGDVETFP--IPKAFVGNQLPFIGFTYYRENLLLSDSPSCRETDSIQ 435
Query: 421 SNTLTKDEDVQRDL----EH-SLQMEAYERRIRRLEQEKLELSRKLQESTQTVQSLHGSS 475
S + +++Q+ L EH S +M+A E ++ + L + +E + +
Sbjct: 436 SRKNEESQEIQKKLYTLEEHLSNEMQAKEELEQKCKSVNTRLEKTAKELEEEITLRKSVE 495
Query: 476 RALSNSNRDKEI---------KKLNEEIERLKNKIADSNRLERQLEDTVALRQEREDSTQ 526
AL R+K + +K + E ++ +N D N L+ QLED Q + ST+
Sbjct: 496 SALRQLEREKALLQHKNAEYQRKADHEADKKRNLENDVNSLKDQLEDLKKRNQNSQISTE 555
Query: 527 RLRGLEKQ----HRVVRQEKE---ELHKQLVEAS---ERLKSQAKELKDAH---QQRKLA 573
++ L++Q + ++R E + L K E+S ++L+S ++L+D + + KL
Sbjct: 556 KVNQLQRQLDETNALLRTESDTAARLRKTQAESSKQIQQLESNNRDLQDKNCLLETAKLK 615
Query: 574 LQ-EFSELNERMAELRAQKQKVSRQLRD-------KEEEMEVATQKVDAMRQEMRRAEKL 625
L+ EF L + R + S + D EE+++ + + E R+ ++
Sbjct: 616 LEKEFINLQSALESERRDRTHGSEIINDLQGRICGLEEDLKNGKILLAKVELEKRQLQER 675
Query: 626 RKELEAQLDDAVAEASKERKLREHSENFCKQMESELEALKVKQGGRGAGATLEHQQEI-S 684
+LE + + + + + K+ + S +Q E+E +A K + + E +E S
Sbjct: 676 FTDLEKEKSNMEIDMTYQLKVIQQS---LEQEEAEHKATKARLADK--NKIYESIEEAKS 730
Query: 685 KIKSELEKKVLFYEEELVRREASHVLEVKNVKKEVHDSESHQLALQ-KEILMLKDKLEKS 743
+ E+EKK+L EE ++++ ++L + + D + Q + E+L KD L +
Sbjct: 731 EAMKEMEKKLL--EERTLKQKVENLLLEAEKRCSLLDCDLKQSQQKINELLKQKDVLNED 788
Query: 744 KRERHNEMEEAV-------GTIKDKYERERAMLFDENKKLTAENEKLCSFVDKLTAQNRQ 796
R ++E+ +K + ++ + E K+L EN L L QN +
Sbjct: 789 VRNLTLKIEQETQKRCLTQNDLKMQTQQVNTLKMSE-KQLKQENNHLMEMKMNLEKQNAE 847
Query: 797 LEDELQDLAAKKESVAHWEAQIAEIIQWVSDEKDARGYLQALASKMTEEL--EALRSSSL 854
L E QD + Q+ E+ D+ +A Y L EL E + L
Sbjct: 848 LRKERQDA----------DGQMKEL----QDQLEAEQYFSTLYKTQVRELKEECEEKTKL 893
Query: 855 GSRTLDPLWKVRRSQKLDMSARLELQ-SALEAEIRAKQLVQEELRKVKDANLTLESKLKD 913
G + L + + ++ ++A+LE+ + ++E A+ + +E+ ++ + E ++K+
Sbjct: 894 G-KELQQKKQELQDERDSLAAQLEITLTKADSEQLARSIAEEQYSDLEKEKIMKELEIKE 952
Query: 914 SEAKNRELLEEMEILKKKMEEKFRADTGLKLPDFQDSIFEYFNTAPLAHDLTFRTSSASE 973
A++++ L E + +EE R T + N A +L + E
Sbjct: 953 MMARHKQELTEKDATIASLEETNRTLTS-----------DVANLANEKEELNNKLKDVQE 1001
Query: 974 QETQAPKPEASPSMSVAASEQQ 995
Q ++ E S + A E+Q
Sbjct: 1002 QLSRLKDEEISAAAIKAQFEKQ 1023
Score = 85.5 bits (210), Expect = 4e-16
Identities = 112/536 (20%), Positives = 246/536 (45%), Gaps = 82/536 (15%)
Query: 428 EDVQRDLEHSLQM-EAYERRIRRLEQE----KLELSRKLQESTQTVQSLHGSSRALSNSN 482
E +RD H ++ + RI LE++ K+ L++ E Q + + SN
Sbjct: 628 ESERRDRTHGSEIINDLQGRICGLEEDLKNGKILLAKVELEKRQLQERFTDLEKEKSNME 687
Query: 483 RDK--EIKKLNEEIER-------LKNKIADSNRLERQLEDTVALRQEREDSTQRLRGLEK 533
D ++K + + +E+ K ++AD N++ +E E ++ ++ +EK
Sbjct: 688 IDMTYQLKVIQQSLEQEEAEHKATKARLADKNKIYESIE---------EAKSEAMKEMEK 738
Query: 534 QHRVVRQEKEELHKQLVEASERLKSQAKELKDAHQQRKLALQEFSELNERMAELRAQKQK 593
+ R K+++ L+EA +R +LK + Q+ L++ LNE + L + ++
Sbjct: 739 KLLEERTLKQKVENLLLEAEKRCSLLDCDLKQSQQKINELLKQKDVLNEDVRNLTLKIEQ 798
Query: 594 VSRQLRDKEEEMEVATQKVDAMRQEMRRAEKLRKELEAQLDDAVAEASKERKLREHSENF 653
+++ + ++++ TQ+V+ ++ ++ ++ L + + ++ RK R+ ++
Sbjct: 799 ETQKRCLTQNDLKMQTQQVNTLKMSEKQLKQENNHLMEMKMNLEKQNAELRKERQDADGQ 858
Query: 654 CKQMESELEALKVKQGGRGAGATLEHQQEISKIKSELEKKVLFYEEELVRREASHVLEVK 713
K+++ +LEA + +TL ++ ++ ++K E E+K +E ++
Sbjct: 859 MKELQDQLEAEQYF-------STL-YKTQVRELKEECEEKTKLGKE------------LQ 898
Query: 714 NVKKEVHDSESHQLALQKEILMLKDKLEKSKR----ERHNEMEEAVGTIKDKYERE---R 766
K+E+ D E LA Q EI + K E+ R E+++++E K+K +E +
Sbjct: 899 QKKQELQD-ERDSLAAQLEITLTKADSEQLARSIAEEQYSDLE------KEKIMKELEIK 951
Query: 767 AMLFDENKKLTAENEKLCSFVDKLTAQNRQLEDELQDLAAKKESVAHWEAQIAEIIQWVS 826
M+ ++LT ++ + S L NR L ++ +LA +KE + + + E + +
Sbjct: 952 EMMARHKQELTEKDATIAS----LEETNRTLTSDVANLANEKEELNNKLKDVQEQLSRLK 1007
Query: 827 DEKDARGYLQA-----LASKMTEELEALRSSSLGSRTLDPLWK-----VRRSQKLDMSAR 876
DE+ + ++A L ++ T + +A+ + +P+ + VRR +K +
Sbjct: 1008 DEEISAAAIKAQFEKQLLTERTLKTQAVNKLAEIMNRKEPVKRGNDTDVRRKEKENRKLH 1067
Query: 877 LELQSALEAEIRAKQLVQEELRKVK-----------DANLTLESKLKDSEAKNREL 921
+EL+S E + Q+EL +++ + +TL+SK D E +L
Sbjct: 1068 MELKSEREKLTQQMIKYQKELNEMQAQIAEESQIRIELQMTLDSKDSDIEQLRSQL 1123
Score = 46.6 bits (109), Expect = 2e-04
Identities = 88/385 (22%), Positives = 156/385 (40%), Gaps = 73/385 (18%)
Query: 411 DRGSLKSIMQSNTLTKDEDVQRDLEHSLQMEAY-----ERRIRRLEQEKLELSRK--LQE 463
+R SL + ++ TLTK + Q L S+ E Y E+ ++ LE +++ K L E
Sbjct: 907 ERDSLAAQLEI-TLTKADSEQ--LARSIAEEQYSDLEKEKIMKELEIKEMMARHKQELTE 963
Query: 464 STQTVQSLHGSSRALS----NSNRDKE-----IKKLNEEIERLKNKIADSNRLERQLEDT 514
T+ SL ++R L+ N +KE +K + E++ RLK++ + ++ Q E
Sbjct: 964 KDATIASLEETNRTLTSDVANLANEKEELNNKLKDVQEQLSRLKDEEISAAAIKAQFEKQ 1023
Query: 515 VALRQEREDSTQRL--------------RGLEKQHRVVRQEKEELHKQLVEASERLKSQA 560
L ER TQ + RG + R +E +LH +L E+L Q
Sbjct: 1024 --LLTERTLKTQAVNKLAEIMNRKEPVKRGNDTDVRRKEKENRKLHMELKSEREKLTQQM 1081
Query: 561 KELKDAHQQRKLALQEFSELNERMAELRAQKQKVSRQLRDKEEEMEVATQKVDAMRQEMR 620
+ + +E +E+ ++AE + ++ L K+ ++E ++ A+ +
Sbjct: 1082 IKYQ----------KELNEMQAQIAEESQIRIELQMTLDSKDSDIEQLRSQLQALHIGLD 1131
Query: 621 RAEKLRKELEAQLDDAVAEASKERKLREHSENFCKQMESELEALKVKQGGRGAGATLEHQ 680
+ +A+ DD E+ E L +L V+ + G
Sbjct: 1132 SSSIGSGPGDAEADDGFPESRLEGWL----------------SLPVRNNTKKFG------ 1169
Query: 681 QEISKIKSELEKKVLFYEEELVRREASHVLEVKNVKKEVHDSESHQL----ALQKEILML 736
+ K KK+LFY+ E +E S+ V ++ K H Q A KEI +
Sbjct: 1170 -WVKKYVIVSSKKILFYDSE-QDKEQSNPYMVLDIDKLFHVRPVTQTDVYRADAKEIPRI 1227
Query: 737 KDKLEKSKRERHNEMEEAVGTIKDK 761
L ++ E E E V + +K
Sbjct: 1228 FQILYANEGESKKEQEFPVEPVGEK 1252
Score = 40.4 bits (93), Expect = 0.015
Identities = 31/109 (28%), Positives = 49/109 (44%), Gaps = 7/109 (6%)
Query: 1099 KGHVKVPKPTGVKK-GWQRAYAVVCDCKLFLYDLPEGKSTQPGVIASQVLDLRDDEFSVS 1157
+G + +P KK GW + Y +V K+ YD + K + VLD+ D F V
Sbjct: 1154 EGWLSLPVRNNTKKFGWVKKYVIVSSKKILFYDSEQDKEQSNPYM---VLDI-DKLFHVR 1209
Query: 1158 SVLASDVIHATRRDIPCIFRVTASLLGAPSKTSSLLILTENENEKRKWV 1206
V +DV A ++IP IF++ + G K + E EK ++
Sbjct: 1210 PVTQTDVYRADAKEIPRIFQILYANEGESKKEQEFPV--EPVGEKSNYI 1256
>gi|126091095 myotonic dystrophy protein kinase isoform 1 [Homo
sapiens]
Length = 639
Score = 462 bits (1188), Expect = e-129
Identities = 251/510 (49%), Positives = 337/510 (66%), Gaps = 42/510 (8%)
Query: 59 AKPFTQLVKEMQLHREDFEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAET 118
A+P +KE++L R+DFEI+KVIGRGAF EVAVVKMK T ++YAMKI+NKW+MLKR E
Sbjct: 64 AEPIVVRLKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEV 123
Query: 119 ACFREERDVLVNGDCQWITALHYAFQDENHLYLVMDYYVGGDLLTLLSKFEDKLPEDMAR 178
+CFREERDVLVNGD +WIT LH+AFQDEN+LYLVM+YYVGGDLLTLLSKF +++P +MAR
Sbjct: 124 SCFREERDVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMAR 183
Query: 179 FYIGEMVLAIDSIHQLHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVQSSVAVG 238
FY+ E+V+AIDS+H+L YVHRDIKPDN+LLD GHIRLADFGSCLK+ DGTV+S VAVG
Sbjct: 184 FYLAEIVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVG 243
Query: 239 TPDYISPEILQAM--EDGMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNH 296
TPDY+SPEILQA+ G G YGPECDWW+LGV YEM YG+TPFYA+S ETYGKI+++
Sbjct: 244 TPDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHY 303
Query: 297 EERFQFPSHVTDVSEEAKDLIQRLICSRERRLGQNGIEDFKKHAFFEGLNWENIRNLEAP 356
+E P V EEA+D IQRL+C E RLG+ G DF+ H FF GL+W+ +R+ P
Sbjct: 304 KEHLSLPLVDEGVPEEARDFIQRLLCPPETRLGRGGAGDFRTHPFFFGLDWDGLRDSVPP 363
Query: 357 YIPDVSSPSDTSNFDVDDDVLRNTEILPPGSHT-------GFSGLHLPFIGFTFTTESCF 409
+ PD +DT NFD+ +D L T ++ G T G+HLPF+G+++ SC
Sbjct: 364 FTPDFEGATDTCNFDLVEDGL--TAMVSGGGETLSDIREGAPLGVHLPFVGYSY---SCM 418
Query: 410 SDRGSLKSIMQSNTLTKDEDVQRDLEHSLQMEAYERRIRRLEQEKLELSRKLQESTQTVQ 469
+ +D +V +++EA + ++ LE S Q+ T V
Sbjct: 419 A--------------LRDSEVPGPT--PMELEAEQLLEPHVQAPSLEPSVSPQDETAEV- 461
Query: 470 SLHGSSRALSNSNRDKEIKKLNEEIERLKNKIADSNRLERQLEDTVALRQEREDSTQRLR 529
A+ + + E+ L E E L+ ++ L R++E A+R + ++ +LR
Sbjct: 462 ---AVPAAVPAAEAEAEV-TLRELQEALEEEVLTRQSLSREME---AIRTDNQNFASQLR 514
Query: 530 GLEKQHRVVRQEKEELHKQLVEASERLKSQ 559
E ++R + E +QL E E L+++
Sbjct: 515 EAEARNR----DLEAHVRQLQERMELLQAE 540
Score = 45.4 bits (106), Expect = 5e-04
Identities = 26/76 (34%), Positives = 43/76 (56%), Gaps = 4/76 (5%)
Query: 878 ELQSALEAEIRAKQLVQEELRKVKDANLTLESKLKDSEAKNRELLEEMEILKKKME---- 933
ELQ ALE E+ +Q + E+ ++ N S+L+++EA+NR+L + L+++ME
Sbjct: 480 ELQEALEEEVLTRQSLSREMEAIRTDNQNFASQLREAEARNRDLEAHVRQLQERMELLQA 539
Query: 934 EKFRADTGLKLPDFQD 949
E A TG+ P D
Sbjct: 540 EGATAVTGVPSPRATD 555
>gi|32698688 citron [Homo sapiens]
Length = 2027
Score = 407 bits (1047), Expect = e-113
Identities = 288/958 (30%), Positives = 482/958 (50%), Gaps = 71/958 (7%)
Query: 23 SALSVETLLDVLVCLYTECSHSALRRDKYVAEFLEWAKPFTQLVKEMQLHREDFEIIKVI 82
S LS E +LD L L+ ECS AL + K+V+ F+ ++E+Q +DFE+ ++
Sbjct: 44 SPLSREGILDALFVLFEECSQPALMKIKHVSNFVRKYSDTIAELQELQPSAKDFEVRSLV 103
Query: 83 GRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVLVNGDCQWITALHYA 142
G G F EV VV+ K T IYAMK++ K +L + + + F EER++L WI L YA
Sbjct: 104 GCGHFAEVQVVREKATGDIYAMKVMKKKALLAQEQVSFFEEERNILSRSTSPWIPQLQYA 163
Query: 143 FQDENHLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFYIGEMVLAIDSIHQLHYVHRDIK 202
FQD+NHLYLVM+Y GGDLL+LL+++ED+L E++ +FY+ E++LA+ S+H + YVHRDIK
Sbjct: 164 FQDKNHLYLVMEYQPGGDLLSLLNRYEDQLDENLIQFYLAELILAVHSVHLMGYVHRDIK 223
Query: 203 PDNVLLDVNGHIRLADFGSCLKMNDDGTVQSSVAVGTPDYISPEILQAME-DGMGKYGPE 261
P+N+L+D GHI+L DFGS KMN + V + + +GTPDY++PE+L M DG G YG +
Sbjct: 224 PENILVDRTGHIKLVDFGSAAKMNSNKMVNAKLPIGTPDYMAPEVLTVMNGDGKGTYGLD 283
Query: 262 CDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHEERFQFPSHVTDVSEEAKDLIQRLI 321
CDWWS+GV YEM+YG +PF + T+ IMN + +FP VS + DLIQ L+
Sbjct: 284 CDWWSVGVIAYEMIYGRSPFAEGTSARTFNNIMNFQRFLKFPDD-PKVSSDFLDLIQSLL 342
Query: 322 CSRERRLGQNGIEDFKKHAFFEGLNWENIRNLEAPYIPDVSSPSDTSNFDVDDDVLRNTE 381
C ++ RL G+ H FF ++W NIRN P++P + S DTSNFD + +
Sbjct: 343 CGQKERLKFEGL---CCHPFFSKIDWNNIRNSPPPFVPTLKSDDDTSNFDEPEKNSWVSS 399
Query: 382 ILPPGSHTGFSGLHLPFIGFTFTTESCFSDRGSLKSIMQSNTLTKDEDVQRDLEHSLQME 441
S +GFSG LPF+GF+++ K++ L + E V L+ +
Sbjct: 400 SPCQLSPSGFSGEELPFVGFSYS-----------KAL---GILGRSESVVSGLDSPAKTS 445
Query: 442 AYERRIRRLEQEKLELSRKLQESTQTVQSLHGSSRALSNSNRDKEIKKLNEEIER----- 496
+ E+++ +E + K + Q + LH + KE++ E +R
Sbjct: 446 SMEKKLLIKSKELQDSQDKCHKMEQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQ 505
Query: 497 -LKNKIADSNRLERQLEDT-VALRQEREDSTQRLRGLEKQHRVVRQEKEELHKQLVEASE 554
L I + + L+R LE + + QE + + Q L + +Q R +++ KE+ ++ VE
Sbjct: 506 DLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDIREQSRKLQEIKEQEYQAQVEEMR 565
Query: 555 RLKSQAKE-LKDAHQQRKLALQEFSELNERMAELRAQKQKVSRQLRDKEEEMEVATQKVD 613
+ +Q +E L A ++ L E E E + + + +L +++ + +
Sbjct: 566 LMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKATECQHKLLKAKDQGKPEVGEYA 625
Query: 614 AMRQEMRRAEKLRKELEAQLDDAVAEASKERKLREHSENFCKQMESELEALKVKQ-GGRG 672
+ + + +EL+ +L+ AV +++ +L ++ ++ E ELE L+ ++ G
Sbjct: 626 KLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQNREDSSEG 685
Query: 673 AGATLEHQQEISKIKSELEKKVLFYEEELVRREASHVLEVK----NVKKEV--------- 719
L +E+ + E + E L ++E + ++K +KK++
Sbjct: 686 IRKKLVEAEELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKETLENM 745
Query: 720 ---HDSESHQ----LALQKEILMLKDKLEKSKRERHNEMEEAVGTIKDKYERERAMLFDE 772
H+ E+H+ L+ QK ++ D +S +R E+ EA +K ++
Sbjct: 746 MQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEA-----NKLAANSSLFTQR 800
Query: 773 NKK--------LTAENEKLCSFVDKLTAQNRQLEDELQDLAAKKESVAHWEAQIAEIIQW 824
N K L + L + KL AQNR+LE++L+ ++ + S + ++ ++
Sbjct: 801 NMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKNRLLELETRLRE 860
Query: 825 VSDEKDARGYLQALASKMTEELEALRSSSLGSRTLDPLWKVRRSQKLDMSARLELQSA-L 883
VS E + + L ++TE +L+ L SQ LE +A
Sbjct: 861 VSLEHEEQKL--ELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEA 918
Query: 884 EAEIRAKQLVQEELRKVKDA-------NLTLESKLKDSEAKNRELLEEMEILKKKMEE 934
E EI+A ++E+++ DA LE +L N EL + L K+++E
Sbjct: 919 EEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDE 976
Score = 159 bits (403), Expect = 2e-38
Identities = 241/1155 (20%), Positives = 476/1155 (41%), Gaps = 112/1155 (9%)
Query: 410 SDRGSLKSIMQSNTLTKDEDVQRDLEHSLQMEAYERRIRRLEQEKLELSRKLQESTQTVQ 469
+D+ +L+++MQ + E + E + A + +IR LEQ +ELS + + +
Sbjct: 737 ADKETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANS-- 794
Query: 470 SLHGSSRALSNSNRDKEIKKLNEEIERLKNKIADSNR-LERQLEDTVALRQEREDSTQRL 528
SL + E+++ +E K+ NR LE QLE + + RL
Sbjct: 795 SLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEK---ISHQDHSDKNRL 851
Query: 529 RGLEKQHRVVRQEKEELHKQLVEASERLKSQAKELKDAHQQRKLALQEFSELNERM-AEL 587
LE + R V E EE Q +E LK Q EL+ + Q+R+ L + ++L
Sbjct: 852 LELETRLREVSLEHEE---QKLE----LKRQLTELQLSLQERESQLTALQAARAALESQL 904
Query: 588 RAQKQKVSRQLRDKEEEMEVAT-------QKVDAMRQEMRRAEKLRKELE------AQLD 634
R K ++ + EEE++ T +K DA+R L ++L A+L+
Sbjct: 905 RQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELN 964
Query: 635 DAVAEASKERKLREHSENFCKQMESELEALKVKQGGRGAGATLEHQ--QEISKIKSELEK 692
+ SK+ + + Q+ SE++ L+ + R T + Q + + + LE+
Sbjct: 965 NQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEE 1024
Query: 693 KVLFYE---EELVRREASHVLEVKNVKKEVHDSESHQLALQKEILMLKDKLEKSKRERHN 749
+V+ E +EL+ +E + + + + D +S +E+ + D ++S+
Sbjct: 1025 QVMDLEALNDELLEKER----QWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQ 1080
Query: 750 EMEEAVGTIKDKYERERAMLFDENKKLTAENEKLCSFVDKLT---AQNRQLEDELQDLAA 806
+ E+ ++ + +A + + L + K S DKL ++ LE + L
Sbjct: 1081 RITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQ 1140
Query: 807 KKESVAHWEAQIAEIIQWVSDEKDA-RGYLQALASKMTEELEALRSSSLGSRTLDPLWKV 865
K E+ + ++ E + + D + ++ L + E L+ R+ L + D +++
Sbjct: 1141 KLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALD--RADLLKTERSDLEYQL 1198
Query: 866 RRSQKLDMSARLELQSALEAEIRAKQLVQEELRKVKDANLTLESKLKDSEAKNRELLEEM 925
Q L +++++ + + + +Q ++ + L S+ K+ A ++ +
Sbjct: 1199 ENIQVLYSHEKVKMEGTISQQTKLIDFLQAKMDQPAKKKKGLFSRRKEDPALPTQVPLQY 1258
Query: 926 EILKKKMEEKFRADTGLKLPDFQDSIFEYFNTAPLAHDLTFRTSSASEQETQAPKPEASP 985
LK +E++ L+ Q + E + R +A + T P P ++P
Sbjct: 1259 NELKLALEKEKARCAELE-EALQKTRIELRSA---------REEAAHRKATDHPHP-STP 1307
Query: 986 SMSVAASEQQEDMARPPQRPSAVPL---PTTQALALAGPKPKA------------HQFSI 1030
+ + + P +PSA+ L P+++ + P+ + H+F++
Sbjct: 1308 ATARQQIAMSAIVRSPEHQPSAMSLLAPPSSRRKESSTPEEFSRRLKERMHHNIPHRFNV 1367
Query: 1031 KSFSSPTQCSHCTSLMVGLIRQGYACEVCSFACHVSCKDGAPQVCPIPPEQSKR------ 1084
T+C+ C V RQ C C CH C P C +P E +
Sbjct: 1368 GLNMRATKCAVCLDT-VHFGRQASKCLECQVMCHPKCSTCLPATCGLPAEYATHFTEAFC 1426
Query: 1085 -----PLGVDVQRGIGTAY-KGHVKVPKPTGV-KKGWQRAYAVVCDCKLFLYDLPEGKST 1137
G+ + + + +G +KVP+ ++GW R Y V+ K+ +YD E +
Sbjct: 1427 RDKMNSPGLQTKEPSSSLHLEGWMKVPRNNKRGQQGWDRKYIVLEGSKVLIYD-NEAREA 1485
Query: 1138 QPGVIASQVLDLRDDEFSV-SSVLASDVIHATRRDIPCIFRVTASLLGAPSKTSSLLILT 1196
+ L L D + S+ +V AS++ + + D+P I ++ + +L +L
Sbjct: 1486 GQRPVEEFELCLPDGDVSIHGAVGASELANTAKADVPYILKMESHPHTTCWPGRTLYLLA 1545
Query: 1197 ENENEKRKWVGILEGLQSILHKNRLRNQVVHVPLEAYDSSLPLIKAI----LTAAIVDAD 1252
+ +K++WV LE S++ R+ + + +SL ++ + + +D
Sbjct: 1546 PSFPDKQRWVTALE---SVVAGGRVSREKAEADAKLLGNSLLKLEGDDRLDMNCTLPFSD 1602
Query: 1253 RIA-VGLEEGLYVIEVTRDVIVRAADCKKVHQIELAPREKIVILLCGRNHHVHLYPWSSL 1311
++ VG EEGLY + V ++ + V QI + + ++++ G + L +
Sbjct: 1603 QVVLVGTEEGLYALNVLKNSLTHVPGIGAVFQIYIIKDLEKLLMIAGEERALCLVDVKKV 1662
Query: 1312 DGAEGSFDIK---------LPETKGCQLMATATLKRNSGTCLFVAVKRLILCYEIQRTKP 1362
+ + KGC L ++ C + K +IL Y +K
Sbjct: 1663 KQSLAQSHLPAQPDISPNIFEAVKGCHLFGAGKIENGLCICAAMPSKVVILRYNENLSKY 1722
Query: 1363 FHRKFNEIVAPGSVQCLAVLRDRLCVGYPSGFCLLSIQGDGQPLNLVNPNDPSLA---FL 1419
RK E P S C+ + +G + + Q + ++ ND SLA F
Sbjct: 1723 CIRKEIETSEPCS--CIHFTNYSILIGTNKFYEIDMKQYTLE--EFLDKNDHSLAPAVFA 1778
Query: 1420 SQQSFDALCAVELES----EEYLLCFSHMGLYVDPQGRRARAQELMWPAAPVACSCSPTH 1475
+ + + V++ S EEYLLCF G++VD GRR+R +L W P+A + +
Sbjct: 1779 ASSNSFPVSIVQVNSAGQREEYLLCFHEFGVFVDSYGRRSRTDDLKWSRLPLAFAYREPY 1838
Query: 1476 VTVYSEYGVDVFDVR 1490
+ V ++V +++
Sbjct: 1839 LFVTHFNSLEVIEIQ 1853
Score = 38.5 bits (88), Expect = 0.057
Identities = 45/227 (19%), Positives = 99/227 (43%), Gaps = 19/227 (8%)
Query: 721 DSESHQLALQKEILMLKDKLEKSKRERHNEMEEAVGTIKDKYERERAMLFDENKKLTAEN 780
DS + +++K++L+ +L+ S+ + H +ME+ + + + A+L + +L A
Sbjct: 439 DSPAKTSSMEKKLLIKSKELQDSQDKCH-KMEQEMTRLHRRVSEVEAVLSQKEVELKASE 497
Query: 781 -------EKLCSFVDKLTAQNRQLEDELQDLAAKKESVAHWEAQIAEIIQWVSDEKDARG 833
+ L +++ + ++ R LE +++ + + I E + + + K+
Sbjct: 498 TQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDIREQSRKLQEIKEQE- 556
Query: 834 YLQALASKMTEELEALRSSSLGSRTLDPLWKVRRSQKLDMSARLELQSALEAEIRAKQLV 893
QA +M + L + +R RRS + R +A E + +A +
Sbjct: 557 -YQAQVEEMRLMMNQLEEDLVSAR--------RRSDLYESELRESRLAAEEFKRKATEC- 606
Query: 894 QEELRKVKDANLTLESKLKDSEAKNRELLEEMEILKKKMEEKFRADT 940
Q +L K KD + E N E +++ L++K+E+ +A T
Sbjct: 607 QHKLLKAKDQGKPEVGEYAKLEKINAEQQLKIQELQEKLEKAVKAST 653
>gi|24307971 serine/threonine kinase 38 like [Homo sapiens]
Length = 464
Score = 305 bits (780), Expect = 3e-82
Identities = 173/415 (41%), Positives = 244/415 (58%), Gaps = 51/415 (12%)
Query: 46 LRRDKYVAEFLEWAKPFTQLVKEMQLHREDFEIIKVIGRGAFGEVAVVKMKNTERIYAMK 105
LRR ++ + E+ + +K +L +DFE +KVIGRGAFGEV +V+ K+T IYAMK
Sbjct: 65 LRRSQHARKETEFLR-----LKRTRLGLDDFESLKVIGRGAFGEVRLVQKKDTGHIYAMK 119
Query: 106 ILNKWEMLKRAETACFREERDVLVNGDCQWITALHYAFQDENHLYLVMDYYVGGDLLTLL 165
IL K +ML++ + A R ERD+LV D W+ + Y+FQD+ +LYL+M++ GGD++TLL
Sbjct: 120 ILRKSDMLEKEQVAHIRAERDILVEADGAWVVKMFYSFQDKRNLYLIMEFLPGGDMMTLL 179
Query: 166 SKFEDKLPEDMARFYIGEMVLAIDSIHQLHYVHRDIKPDNVLLDVNGHIRLADFGSCL-- 223
K +D L E+ +FYI E VLAID+IHQL ++HRDIKPDN+LLD GH++L+DFG C
Sbjct: 180 MK-KDTLTEEETQFYISETVLAIDAIHQLGFIHRDIKPDNLLLDAKGHVKLSDFGLCTGL 238
Query: 224 -----------------------KMNDDGTVQ---------SSVAVGTPDYISPEILQAM 251
MN + + VGTPDYI+PE+ M
Sbjct: 239 KKAHRTEFYRNLTHNPPSDFSFQNMNSKRKAETWKKNRRQLAYSTVGTPDYIAPEVF--M 296
Query: 252 EDGMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHEERFQFPSHVTDVSE 311
+ G Y CDWWSLGV MYEML G PF +E+ ETY K+MN +E FP V +SE
Sbjct: 297 QTG---YNKLCDWWSLGVIMYEMLIGYPPFCSETPQETYRKVMNWKETLVFPPEV-PISE 352
Query: 312 EAKDLIQRLICSRERRLGQNGIEDFKKHAFFEGLNWENIRNLEAPYIPDVSSPSDTSNFD 371
+AKDLI R E R+G +G+E+ K H FFEG++WE+IR A ++ S DTSNFD
Sbjct: 353 KAKDLILRFCIDSENRIGNSGVEEIKGHPFFEGVDWEHIRERPAAIPIEIKSIDDTSNFD 412
Query: 372 --VDDDVLRNTEILPPGSHTGFSGLHLPFIGFTFTTESCFSDRGSLKSIMQSNTL 424
+ D+L + +P + + F+ +T+ + RGS+ + M++ L
Sbjct: 413 DFPESDIL---QPVPNTTEPDYKSKDWVFLNYTYKRFEGLTQRGSIPTYMKAGKL 464
>gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [Homo
sapiens]
Length = 431
Score = 205 bits (522), Expect = 3e-52
Identities = 116/302 (38%), Positives = 176/302 (58%), Gaps = 17/302 (5%)
Query: 75 DFEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVLV-NGDC 133
DF +KVIG+G+FG+V + + K E YA+K+L K +LK+ E ER+VL+ N
Sbjct: 97 DFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKH 156
Query: 134 QWITALHYAFQDENHLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFYIGEMVLAIDSIHQ 193
++ LH++FQ + LY V+DY GG+L L + E E ARFY E+ A+ +H
Sbjct: 157 PFLVGLHFSFQTADKLYFVLDYINGGELFYHLQR-ERCFLEPRARFYAAEIASALGYLHS 215
Query: 194 LHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVQSSVAVGTPDYISPEILQAMED 253
L+ V+RD+KP+N+LLD GHI L DFG C K N + +S GTP+Y++PE+L
Sbjct: 216 LNIVYRDLKPENILLDSQGHIVLTDFGLC-KENIEHNSTTSTFCGTPEYLAPEVLHKQ-- 272
Query: 254 GMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHEERFQFPSHVTDVSEEA 313
Y DWW LG +YEMLYG PFY+ + E Y I+N + + +++ A
Sbjct: 273 ---PYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLK-----PNITNSA 324
Query: 314 KDLIQRLI-CSRERRLG-QNGIEDFKKHAFFEGLNWENIRN--LEAPYIPDVSSPSDTSN 369
+ L++ L+ R +RLG ++ + K H FF +NW+++ N + P+ P+VS P+D +
Sbjct: 325 RHLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRH 384
Query: 370 FD 371
FD
Sbjct: 385 FD 386
>gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4
[Homo sapiens]
Length = 445
Score = 205 bits (522), Expect = 3e-52
Identities = 116/302 (38%), Positives = 176/302 (58%), Gaps = 17/302 (5%)
Query: 75 DFEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVLV-NGDC 133
DF +KVIG+G+FG+V + + K E YA+K+L K +LK+ E ER+VL+ N
Sbjct: 111 DFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKH 170
Query: 134 QWITALHYAFQDENHLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFYIGEMVLAIDSIHQ 193
++ LH++FQ + LY V+DY GG+L L + E E ARFY E+ A+ +H
Sbjct: 171 PFLVGLHFSFQTADKLYFVLDYINGGELFYHLQR-ERCFLEPRARFYAAEIASALGYLHS 229
Query: 194 LHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVQSSVAVGTPDYISPEILQAMED 253
L+ V+RD+KP+N+LLD GHI L DFG C K N + +S GTP+Y++PE+L
Sbjct: 230 LNIVYRDLKPENILLDSQGHIVLTDFGLC-KENIEHNSTTSTFCGTPEYLAPEVLHKQ-- 286
Query: 254 GMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHEERFQFPSHVTDVSEEA 313
Y DWW LG +YEMLYG PFY+ + E Y I+N + + +++ A
Sbjct: 287 ---PYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLK-----PNITNSA 338
Query: 314 KDLIQRLI-CSRERRLG-QNGIEDFKKHAFFEGLNWENIRN--LEAPYIPDVSSPSDTSN 369
+ L++ L+ R +RLG ++ + K H FF +NW+++ N + P+ P+VS P+D +
Sbjct: 339 RHLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRH 398
Query: 370 FD 371
FD
Sbjct: 399 FD 400
>gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3
[Homo sapiens]
Length = 459
Score = 205 bits (522), Expect = 3e-52
Identities = 116/302 (38%), Positives = 176/302 (58%), Gaps = 17/302 (5%)
Query: 75 DFEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVLV-NGDC 133
DF +KVIG+G+FG+V + + K E YA+K+L K +LK+ E ER+VL+ N
Sbjct: 125 DFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKH 184
Query: 134 QWITALHYAFQDENHLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFYIGEMVLAIDSIHQ 193
++ LH++FQ + LY V+DY GG+L L + E E ARFY E+ A+ +H
Sbjct: 185 PFLVGLHFSFQTADKLYFVLDYINGGELFYHLQR-ERCFLEPRARFYAAEIASALGYLHS 243
Query: 194 LHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVQSSVAVGTPDYISPEILQAMED 253
L+ V+RD+KP+N+LLD GHI L DFG C K N + +S GTP+Y++PE+L
Sbjct: 244 LNIVYRDLKPENILLDSQGHIVLTDFGLC-KENIEHNSTTSTFCGTPEYLAPEVLHKQ-- 300
Query: 254 GMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHEERFQFPSHVTDVSEEA 313
Y DWW LG +YEMLYG PFY+ + E Y I+N + + +++ A
Sbjct: 301 ---PYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLK-----PNITNSA 352
Query: 314 KDLIQRLI-CSRERRLG-QNGIEDFKKHAFFEGLNWENIRN--LEAPYIPDVSSPSDTSN 369
+ L++ L+ R +RLG ++ + K H FF +NW+++ N + P+ P+VS P+D +
Sbjct: 353 RHLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRH 412
Query: 370 FD 371
FD
Sbjct: 413 FD 414
>gi|219521876 serum/glucocorticoid regulated kinase 1 isoform 2
[Homo sapiens]
Length = 526
Score = 205 bits (522), Expect = 3e-52
Identities = 116/302 (38%), Positives = 176/302 (58%), Gaps = 17/302 (5%)
Query: 75 DFEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVLV-NGDC 133
DF +KVIG+G+FG+V + + K E YA+K+L K +LK+ E ER+VL+ N
Sbjct: 192 DFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKH 251
Query: 134 QWITALHYAFQDENHLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFYIGEMVLAIDSIHQ 193
++ LH++FQ + LY V+DY GG+L L + E E ARFY E+ A+ +H
Sbjct: 252 PFLVGLHFSFQTADKLYFVLDYINGGELFYHLQR-ERCFLEPRARFYAAEIASALGYLHS 310
Query: 194 LHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVQSSVAVGTPDYISPEILQAMED 253
L+ V+RD+KP+N+LLD GHI L DFG C K N + +S GTP+Y++PE+L
Sbjct: 311 LNIVYRDLKPENILLDSQGHIVLTDFGLC-KENIEHNSTTSTFCGTPEYLAPEVLHKQ-- 367
Query: 254 GMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHEERFQFPSHVTDVSEEA 313
Y DWW LG +YEMLYG PFY+ + E Y I+N + + +++ A
Sbjct: 368 ---PYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLK-----PNITNSA 419
Query: 314 KDLIQRLI-CSRERRLG-QNGIEDFKKHAFFEGLNWENIRN--LEAPYIPDVSSPSDTSN 369
+ L++ L+ R +RLG ++ + K H FF +NW+++ N + P+ P+VS P+D +
Sbjct: 420 RHLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRH 479
Query: 370 FD 371
FD
Sbjct: 480 FD 481
>gi|7657526 ribosomal protein S6 kinase polypeptide 6 [Homo sapiens]
Length = 745
Score = 205 bits (522), Expect = 3e-52
Identities = 134/372 (36%), Positives = 203/372 (54%), Gaps = 25/372 (6%)
Query: 61 PFTQLVKE--MQLHREDFEIIKVIGRGAFGEVAVVKMK---NTERIYAMKILNKWEMLKR 115
P T VKE + FE++KV+G+G+FG+V +V+ K + ++YAMK+L K LK
Sbjct: 56 PITHHVKEGYEKADPAQFELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKK-ASLKV 114
Query: 116 AETACFREERDVLVNGDCQWITALHYAFQDENHLYLVMDYYVGGDLLTLLSKFEDKLPED 175
+ + ERD+LV + +I LHYAFQ E LYL++D+ GGD+ T LSK E E+
Sbjct: 115 RDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSK-EVLFTEE 173
Query: 176 MARFYIGEMVLAIDSIHQLHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVQSSV 235
+FY+ E+ LA+D +HQL V+RD+KP+N+LLD GHI+L DFG K + D ++
Sbjct: 174 DVKFYLAELALALDHLHQLGIVYRDLKPENILLDEIGHIKLTDFG-LSKESVDQEKKAYS 232
Query: 236 AVGTPDYISPEILQAMEDGMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMN 295
GT +Y++PE++ + DWWS GV M+EML G PF + ET I+
Sbjct: 233 FCGTVEYMAPEVVNRR-----GHSQSADWWSYGVLMFEMLTGTLPFQGKDRNETMNMIL- 286
Query: 296 HEERFQFPSHVTDVSEEAKDLIQRLI-CSRERRLGQNGIEDFKKHAFFEGLNWENI--RN 352
+ + P +S EA+ L++ L + RLG G+E+ K+H FF ++W+ + R
Sbjct: 287 -KAKLGMPQF---LSAEAQSLLRMLFKRNPANRLGSEGVEEIKRHLFFANIDWDKLYKRE 342
Query: 353 LEAPYIPDVSSPSDTSNFDVDDDVLRNTEILPPGSHTGFSGLHLPFIGFTFTTESCFSDR 412
++ P+ P P DT F D + T PG + H F GF+F S ++
Sbjct: 343 VQPPFKPASGKPDDT--FCFDPEFTAKTPKDSPGLPAS-ANAHQLFKGFSFVATS-IAEE 398
Query: 413 GSLKSIMQSNTL 424
+ I +N L
Sbjct: 399 YKITPITSANVL 410
Score = 83.6 bits (205), Expect = 2e-15
Identities = 80/272 (29%), Positives = 132/272 (48%), Gaps = 29/272 (10%)
Query: 61 PFTQLVKEMQLHREDFEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETAC 120
P Q+ E +E+ + IG G++ T +A+KI++K KR +
Sbjct: 411 PIVQINGNAAQFGEVYELKEDIGVGSYSVCKRCIHATTNMEFAVKIIDK---SKRDPS-- 465
Query: 121 FREERDVLVN-GDCQWITALHYAFQDENHLYLVMDYYVGGDLLTLLSK---FEDKLPEDM 176
EE ++L+ G I L F D ++YLV D GG+LL + K F ++ D+
Sbjct: 466 --EEIEILMRYGQHPNIITLKDVFDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDI 523
Query: 177 ARFYIGEMVLAIDSIHQLHYVHRDIKPDNVL-LDVNGH---IRLADFGSCLKMNDDGTVQ 232
Y+ + +D +H VHRD+KP N+L +D + IR+ DFG ++ + +
Sbjct: 524 --LYV--ISKTVDYLHCQGVVHRDLKPSNILYMDESASADSIRICDFGFAKQLRGENGLL 579
Query: 233 SSVAVGTPDYISPEILQAMEDGMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGK 292
+ T ++++PE+L M+ G Y CD WSLGV Y ML G TPF A +T +
Sbjct: 580 LTPCY-TANFVAPEVL--MQQG---YDAACDIWSLGVLFYTMLAGYTPF-ANGPNDTPEE 632
Query: 293 IMNHEERFQFP---SHVTDVSEEAKDLIQRLI 321
I+ +F + ++S+ AKDL+ ++
Sbjct: 633 ILLRIGNGKFSLSGGNWDNISDGAKDLLSHML 664
>gi|46909584 cAMP-dependent protein kinase catalytic subunit alpha
isoform 2 [Homo sapiens]
Length = 343
Score = 204 bits (520), Expect = 5e-52
Identities = 113/305 (37%), Positives = 181/305 (59%), Gaps = 20/305 (6%)
Query: 72 HREDFEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVLVNG 131
H + FE IK +G G+FG V +VK K T YAMKIL+K +++K + E+ +L
Sbjct: 32 HLDQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAV 91
Query: 132 DCQWITALHYAFQDENHLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFYIGEMVLAIDSI 191
+ ++ L ++F+D ++LY+VM+Y GG++ + L + + E ARFY ++VL + +
Sbjct: 92 NFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRI-GRFSEPHARFYAAQIVLTFEYL 150
Query: 192 HQLHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVQSSVAVGTPDYISPEILQAM 251
H L ++RD+KP+N+L+D G+I++ DFG ++ ++ GTP+Y++PEI+ +
Sbjct: 151 HSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKG----RTWTLCGTPEYLAPEIILSK 206
Query: 252 EDGMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHEERFQFPSHVTDVSE 311
Y DWW+LGV +YEM G PF+A+ ++ Y KI++ + R FPSH S
Sbjct: 207 -----GYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVR--FPSH---FSS 256
Query: 312 EAKDLIQRLI-CSRERRLG--QNGIEDFKKHAFFEGLNWENI--RNLEAPYIPDVSSPSD 366
+ KDL++ L+ +R G +NG+ D K H +F +W I R +EAP+IP P D
Sbjct: 257 DLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGD 316
Query: 367 TSNFD 371
TSNFD
Sbjct: 317 TSNFD 321
>gi|4506055 cAMP-dependent protein kinase catalytic subunit alpha
isoform 1 [Homo sapiens]
Length = 351
Score = 204 bits (520), Expect = 5e-52
Identities = 113/305 (37%), Positives = 181/305 (59%), Gaps = 20/305 (6%)
Query: 72 HREDFEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVLVNG 131
H + FE IK +G G+FG V +VK K T YAMKIL+K +++K + E+ +L
Sbjct: 40 HLDQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAV 99
Query: 132 DCQWITALHYAFQDENHLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFYIGEMVLAIDSI 191
+ ++ L ++F+D ++LY+VM+Y GG++ + L + + E ARFY ++VL + +
Sbjct: 100 NFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRI-GRFSEPHARFYAAQIVLTFEYL 158
Query: 192 HQLHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVQSSVAVGTPDYISPEILQAM 251
H L ++RD+KP+N+L+D G+I++ DFG ++ ++ GTP+Y++PEI+ +
Sbjct: 159 HSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKG----RTWTLCGTPEYLAPEIILSK 214
Query: 252 EDGMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHEERFQFPSHVTDVSE 311
Y DWW+LGV +YEM G PF+A+ ++ Y KI++ + R FPSH S
Sbjct: 215 -----GYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVR--FPSH---FSS 264
Query: 312 EAKDLIQRLI-CSRERRLG--QNGIEDFKKHAFFEGLNWENI--RNLEAPYIPDVSSPSD 366
+ KDL++ L+ +R G +NG+ D K H +F +W I R +EAP+IP P D
Sbjct: 265 DLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGD 324
Query: 367 TSNFD 371
TSNFD
Sbjct: 325 TSNFD 329
>gi|4506057 cAMP-dependent protein kinase catalytic subunit beta
isoform 2 [Homo sapiens]
Length = 351
Score = 204 bits (520), Expect = 5e-52
Identities = 115/303 (37%), Positives = 181/303 (59%), Gaps = 20/303 (6%)
Query: 74 EDFEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVLVNGDC 133
EDFE K +G G+FG V +VK K TE+ YAMKIL+K +++K + E+ +L +
Sbjct: 42 EDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 101
Query: 134 QWITALHYAFQDENHLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFYIGEMVLAIDSIHQ 193
++ L YAF+D ++LY+VM+Y GG++ + L + + E ARFY ++VL + +H
Sbjct: 102 PFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRI-GRFSEPHARFYAAQIVLTFEYLHS 160
Query: 194 LHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVQSSVAVGTPDYISPEILQAMED 253
L ++RD+KP+N+L+D G+I++ DFG ++ ++ GTP+Y++PEI+ +
Sbjct: 161 LDLIYRDLKPENLLIDHQGYIQVTDFGFAKRVKG----RTWTLCGTPEYLAPEIILSK-- 214
Query: 254 GMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHEERFQFPSHVTDVSEEA 313
Y DWW+LGV +YEM G PF+A+ ++ Y KI++ + R FPSH S +
Sbjct: 215 ---GYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVR--FPSH---FSSDL 266
Query: 314 KDLIQRLI-CSRERRLG--QNGIEDFKKHAFFEGLNWENI--RNLEAPYIPDVSSPSDTS 368
KDL++ L+ +R G +NG+ D K H +F +W I R +EAP+IP DTS
Sbjct: 267 KDLLRNLLQVDLTKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAPFIPKFRGSGDTS 326
Query: 369 NFD 371
NFD
Sbjct: 327 NFD 329
>gi|33636738 cAMP-dependent protein kinase catalytic subunit beta
isoform 1 [Homo sapiens]
Length = 398
Score = 204 bits (520), Expect = 5e-52
Identities = 115/303 (37%), Positives = 181/303 (59%), Gaps = 20/303 (6%)
Query: 74 EDFEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVLVNGDC 133
EDFE K +G G+FG V +VK K TE+ YAMKIL+K +++K + E+ +L +
Sbjct: 89 EDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 148
Query: 134 QWITALHYAFQDENHLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFYIGEMVLAIDSIHQ 193
++ L YAF+D ++LY+VM+Y GG++ + L + + E ARFY ++VL + +H
Sbjct: 149 PFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRI-GRFSEPHARFYAAQIVLTFEYLHS 207
Query: 194 LHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVQSSVAVGTPDYISPEILQAMED 253
L ++RD+KP+N+L+D G+I++ DFG ++ ++ GTP+Y++PEI+ +
Sbjct: 208 LDLIYRDLKPENLLIDHQGYIQVTDFGFAKRVKG----RTWTLCGTPEYLAPEIILSK-- 261
Query: 254 GMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHEERFQFPSHVTDVSEEA 313
Y DWW+LGV +YEM G PF+A+ ++ Y KI++ + R FPSH S +
Sbjct: 262 ---GYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVR--FPSH---FSSDL 313
Query: 314 KDLIQRLI-CSRERRLG--QNGIEDFKKHAFFEGLNWENI--RNLEAPYIPDVSSPSDTS 368
KDL++ L+ +R G +NG+ D K H +F +W I R +EAP+IP DTS
Sbjct: 314 KDLLRNLLQVDLTKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAPFIPKFRGSGDTS 373
Query: 369 NFD 371
NFD
Sbjct: 374 NFD 376
>gi|25168261 serum/glucocorticoid regulated kinase 2 isoform alpha
[Homo sapiens]
Length = 367
Score = 203 bits (516), Expect = 1e-51
Identities = 121/339 (35%), Positives = 188/339 (55%), Gaps = 19/339 (5%)
Query: 75 DFEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVLV-NGDC 133
DF+ +KVIG+G +G+V + K K+ YA+K+L K +LK+ E + ER VL+ N
Sbjct: 34 DFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERSVLLKNVRH 93
Query: 134 QWITALHYAFQDENHLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFYIGEMVLAIDSIHQ 193
++ L Y+FQ LY V+DY GG+L L + E + E ARFY E+ AI +H
Sbjct: 94 PFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQR-ERRFLEPRARFYAAEVASAIGYLHS 152
Query: 194 LHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVQSSVAVGTPDYISPEILQAMED 253
L+ ++RD+KP+N+LLD GH+ L DFG C K + +S GTP+Y++PE+L+
Sbjct: 153 LNIIYRDLKPENILLDCQGHVVLTDFGLC-KEGVEPEDTTSTFCGTPEYLAPEVLR---- 207
Query: 254 GMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHEERFQFPSHVTDVSEEA 313
Y DWW LG +YEML+G PFY++ + + Y I++ + Q P T A
Sbjct: 208 -KEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYENILH--QPLQIPGGRT---VAA 261
Query: 314 KDLIQRLICSRER-RLGQNG-IEDFKKHAFFEGLNWENI--RNLEAPYIPDVSSPSDTSN 369
DL+Q L+ +R RLG + K H FF +NW+++ + L P+ P+V+ P+D +
Sbjct: 262 CDLLQSLLHKDQRQRLGSKADFLEIKNHVFFSPINWDDLYHKRLTPPFNPNVTGPADLKH 321
Query: 370 FDVD--DDVLRNTEILPPGSHTGFSGLHLPFIGFTFTTE 406
FD + + + + P + SG F+GF++ E
Sbjct: 322 FDPEFTQEAVSKSIGCTPDTVASSSGASSAFLGFSYAPE 360
>gi|20127541 serum/glucocorticoid regulated kinase 2 isoform beta
[Homo sapiens]
Length = 427
Score = 203 bits (516), Expect = 1e-51
Identities = 121/339 (35%), Positives = 188/339 (55%), Gaps = 19/339 (5%)
Query: 75 DFEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVLV-NGDC 133
DF+ +KVIG+G +G+V + K K+ YA+K+L K +LK+ E + ER VL+ N
Sbjct: 94 DFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERSVLLKNVRH 153
Query: 134 QWITALHYAFQDENHLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFYIGEMVLAIDSIHQ 193
++ L Y+FQ LY V+DY GG+L L + E + E ARFY E+ AI +H
Sbjct: 154 PFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQR-ERRFLEPRARFYAAEVASAIGYLHS 212
Query: 194 LHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVQSSVAVGTPDYISPEILQAMED 253
L+ ++RD+KP+N+LLD GH+ L DFG C K + +S GTP+Y++PE+L+
Sbjct: 213 LNIIYRDLKPENILLDCQGHVVLTDFGLC-KEGVEPEDTTSTFCGTPEYLAPEVLR---- 267
Query: 254 GMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHEERFQFPSHVTDVSEEA 313
Y DWW LG +YEML+G PFY++ + + Y I++ + Q P T A
Sbjct: 268 -KEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYENILH--QPLQIPGGRT---VAA 321
Query: 314 KDLIQRLICSRER-RLGQNG-IEDFKKHAFFEGLNWENI--RNLEAPYIPDVSSPSDTSN 369
DL+Q L+ +R RLG + K H FF +NW+++ + L P+ P+V+ P+D +
Sbjct: 322 CDLLQSLLHKDQRQRLGSKADFLEIKNHVFFSPINWDDLYHKRLTPPFNPNVTGPADLKH 381
Query: 370 FDVD--DDVLRNTEILPPGSHTGFSGLHLPFIGFTFTTE 406
FD + + + + P + SG F+GF++ E
Sbjct: 382 FDPEFTQEAVSKSIGCTPDTVASSSGASSAFLGFSYAPE 420
>gi|32528297 ribosomal protein S6 kinase, polypeptide 5 isoform b
[Homo sapiens]
Length = 549
Score = 202 bits (515), Expect = 2e-51
Identities = 124/337 (36%), Positives = 197/337 (58%), Gaps = 26/337 (7%)
Query: 74 EDFEIIKVIGRGAFGEVAVVKM---KNTERIYAMKILNKWEMLKRAETACF-REERDVLV 129
E+FE++KV+G GA+G+V +V+ +T ++YAMK+L K ++++A+T R ER VL
Sbjct: 47 ENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLE 106
Query: 130 N-GDCQWITALHYAFQDENHLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFYIGEMVLAI 188
+ ++ LHYAFQ E L+L++DY GG+L T LS+ E + E + Y+GE+VLA+
Sbjct: 107 HIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRE-RFTEHEVQIYVGEIVLAL 165
Query: 189 DSIHQLHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVQSSVAVGTPDYISPEIL 248
+ +H+L ++RDIK +N+LLD NGH+ L DFG + D T ++ GT +Y++P+I+
Sbjct: 166 EHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYSFCGTIEYMAPDIV 225
Query: 249 QAMEDGMGKYGPECDWWSLGVCMYEMLYGETPFYAE----SLVETYGKIMNHEERFQFPS 304
+ + G K DWWSLGV MYE+L G +PF + S E +I+ E P
Sbjct: 226 RGGDSGHDK---AVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKSE-----PP 277
Query: 305 HVTDVSEEAKDLIQRLICSRERR---LGQNGIEDFKKHAFFEGLNWENI--RNLEAPYIP 359
+ ++S AKDLIQRL+ ++ G ++ K+H FF+ +NW+++ + + AP+ P
Sbjct: 278 YPQEMSALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLFFQKINWDDLAAKKVPAPFKP 337
Query: 360 DVSSPSDTSNFD---VDDDVLRNTEILPPGSHTGFSG 393
+ D SNF + D + LP S F G
Sbjct: 338 VIRDELDVSNFAEEFTEMDPTYSPAALPQSSEKLFQG 374
Score = 55.5 bits (132), Expect = 4e-07
Identities = 36/125 (28%), Positives = 62/125 (49%), Gaps = 6/125 (4%)
Query: 80 KVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVLVNGDCQWITAL 139
K +G G+F K + + +A+KI++K R E +E + + I L
Sbjct: 430 KPLGEGSFSICRKCVHKKSNQAFAVKIISK-----RMEANTQKEITALKLCEGHPNIVKL 484
Query: 140 HYAFQDENHLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFYIGEMVLAIDSIHQLHYVHR 199
H F D+ H +LVM+ GG+L + K + E A + + ++V A+ +H + VHR
Sbjct: 485 HEVFHDQLHTFLVMELLNGGELFERIKK-KKHFSETEASYIMRKLVSAVSHMHDVGVVHR 543
Query: 200 DIKPD 204
D+KP+
Sbjct: 544 DLKPE 548
>gi|32528295 ribosomal protein S6 kinase, polypeptide 5 isoform a
[Homo sapiens]
Length = 802
Score = 202 bits (515), Expect = 2e-51
Identities = 124/337 (36%), Positives = 197/337 (58%), Gaps = 26/337 (7%)
Query: 74 EDFEIIKVIGRGAFGEVAVVKM---KNTERIYAMKILNKWEMLKRAETACF-REERDVLV 129
E+FE++KV+G GA+G+V +V+ +T ++YAMK+L K ++++A+T R ER VL
Sbjct: 47 ENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLE 106
Query: 130 N-GDCQWITALHYAFQDENHLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFYIGEMVLAI 188
+ ++ LHYAFQ E L+L++DY GG+L T LS+ E + E + Y+GE+VLA+
Sbjct: 107 HIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRE-RFTEHEVQIYVGEIVLAL 165
Query: 189 DSIHQLHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVQSSVAVGTPDYISPEIL 248
+ +H+L ++RDIK +N+LLD NGH+ L DFG + D T ++ GT +Y++P+I+
Sbjct: 166 EHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYSFCGTIEYMAPDIV 225
Query: 249 QAMEDGMGKYGPECDWWSLGVCMYEMLYGETPFYAE----SLVETYGKIMNHEERFQFPS 304
+ + G K DWWSLGV MYE+L G +PF + S E +I+ E P
Sbjct: 226 RGGDSGHDK---AVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKSE-----PP 277
Query: 305 HVTDVSEEAKDLIQRLICSRERR---LGQNGIEDFKKHAFFEGLNWENI--RNLEAPYIP 359
+ ++S AKDLIQRL+ ++ G ++ K+H FF+ +NW+++ + + AP+ P
Sbjct: 278 YPQEMSALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLFFQKINWDDLAAKKVPAPFKP 337
Query: 360 DVSSPSDTSNFD---VDDDVLRNTEILPPGSHTGFSG 393
+ D SNF + D + LP S F G
Sbjct: 338 VIRDELDVSNFAEEFTEMDPTYSPAALPQSSEKLFQG 374
Score = 104 bits (260), Expect = 6e-22
Identities = 84/266 (31%), Positives = 132/266 (49%), Gaps = 26/266 (9%)
Query: 80 KVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVLVNGDCQWITAL 139
K +G G+F K + + +A+KI++K R E +E + + I L
Sbjct: 430 KPLGEGSFSICRKCVHKKSNQAFAVKIISK-----RMEANTQKEITALKLCEGHPNIVKL 484
Query: 140 HYAFQDENHLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFYIGEMVLAIDSIHQLHYVHR 199
H F D+ H +LVM+ GG+L + K + E A + + ++V A+ +H + VHR
Sbjct: 485 HEVFHDQLHTFLVMELLNGGELFERIKK-KKHFSETEASYIMRKLVSAVSHMHDVGVVHR 543
Query: 200 DIKPDNVLL---DVNGHIRLADFGSC-LKMNDDGTVQSSVAVGTPDYISPEILQAMEDGM 255
D+KP+N+L + N I++ DFG LK D+ +++ T Y +PE+L
Sbjct: 544 DLKPENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTPCF--TLHYAAPELLN-----Q 596
Query: 256 GKYGPECDWWSLGVCMYEMLYGETPFYAE-------SLVETYGKIMNHEERFQFPSHVTD 308
Y CD WSLGV +Y ML G+ PF + S VE KI + F+ + +
Sbjct: 597 NGYDESCDLWSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEGEAW-KN 655
Query: 309 VSEEAKDLIQRLI-CSRERRLGQNGI 333
VS+EAKDLIQ L+ +RL +G+
Sbjct: 656 VSQEAKDLIQGLLTVDPNKRLKMSGL 681
>gi|4502023 AKT2 kinase [Homo sapiens]
Length = 481
Score = 202 bits (513), Expect = 3e-51
Identities = 124/327 (37%), Positives = 182/327 (55%), Gaps = 18/327 (5%)
Query: 75 DFEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVLVNGDCQ 134
DF+ +K++G+G FG+V +V+ K T R YAMKIL K ++ + E A E VL N
Sbjct: 151 DFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTRHP 210
Query: 135 WITALHYAFQDENHLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFYIGEMVLAIDSIHQL 194
++TAL YAFQ + L VM+Y GG+L LS+ E E+ ARFY E+V A++ +H
Sbjct: 211 FLTALKYAFQTHDRLCFVMEYANGGELFFHLSR-ERVFTEERARFYGAEIVSALEYLHSR 269
Query: 195 HYVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVQSSVAVGTPDYISPEILQAMEDG 254
V+RDIK +N++LD +GHI++ DFG C + DG + GTP+Y++PE+L+ +
Sbjct: 270 DVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFC-GTPEYLAPEVLEDND-- 326
Query: 255 MGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHEERFQFPSHVTDVSEEAK 314
YG DWW LGV MYEM+ G PFY + + I+ E RF +S EAK
Sbjct: 327 ---YGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFP-----RTLSPEAK 378
Query: 315 DLIQRLICSRERRLGQNGIEDFK---KHAFFEGLNWENI--RNLEAPYIPDVSSPSDTSN 369
L+ L+ ++ G D K +H FF +NW+++ + L P+ P V+S DT
Sbjct: 379 SLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQKKLLPPFKPQVTSEVDTRY 438
Query: 370 FDVDDDVLRNTEILPPGSHTGFSGLHL 396
FD D+ ++ I PP + L L
Sbjct: 439 FD-DEFTAQSITITPPDRYDSLGLLEL 464
>gi|62241015 AKT1 kinase [Homo sapiens]
Length = 480
Score = 201 bits (511), Expect = 5e-51
Identities = 122/317 (38%), Positives = 182/317 (57%), Gaps = 19/317 (5%)
Query: 75 DFEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVLVNGDCQ 134
+FE +K++G+G FG+V +VK K T R YAMKIL K ++ + E A E VL N
Sbjct: 149 EFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHP 208
Query: 135 WITALHYAFQDENHLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFYIGEMVLAIDSIH-Q 193
++TAL Y+FQ + L VM+Y GG+L LS+ E ED ARFY E+V A+D +H +
Sbjct: 209 FLTALKYSFQTHDRLCFVMEYANGGELFFHLSR-ERVFSEDRARFYGAEIVSALDYLHSE 267
Query: 194 LHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVQSSVAVGTPDYISPEILQAMED 253
+ V+RD+K +N++LD +GHI++ DFG C + DG + GTP+Y++PE+L+ +
Sbjct: 268 KNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFC-GTPEYLAPEVLEDND- 325
Query: 254 GMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHEERFQFPSHVTDVSEEA 313
YG DWW LGV MYEM+ G PFY + + + I+ E RF + EA
Sbjct: 326 ----YGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFP-----RTLGPEA 376
Query: 314 KDLIQRLICSRERRLGQNGIEDFK---KHAFFEGLNWENI--RNLEAPYIPDVSSPSDTS 368
K L+ L+ ++ G ED K +H FF G+ W+++ + L P+ P V+S +DT
Sbjct: 377 KSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTR 436
Query: 369 NFDVDDDVLRNTEILPP 385
FD ++ + I PP
Sbjct: 437 YFD-EEFTAQMITITPP 452
>gi|62241013 AKT1 kinase [Homo sapiens]
Length = 480
Score = 201 bits (511), Expect = 5e-51
Identities = 122/317 (38%), Positives = 182/317 (57%), Gaps = 19/317 (5%)
Query: 75 DFEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVLVNGDCQ 134
+FE +K++G+G FG+V +VK K T R YAMKIL K ++ + E A E VL N
Sbjct: 149 EFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHP 208
Query: 135 WITALHYAFQDENHLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFYIGEMVLAIDSIH-Q 193
++TAL Y+FQ + L VM+Y GG+L LS+ E ED ARFY E+V A+D +H +
Sbjct: 209 FLTALKYSFQTHDRLCFVMEYANGGELFFHLSR-ERVFSEDRARFYGAEIVSALDYLHSE 267
Query: 194 LHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVQSSVAVGTPDYISPEILQAMED 253
+ V+RD+K +N++LD +GHI++ DFG C + DG + GTP+Y++PE+L+ +
Sbjct: 268 KNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFC-GTPEYLAPEVLEDND- 325
Query: 254 GMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHEERFQFPSHVTDVSEEA 313
YG DWW LGV MYEM+ G PFY + + + I+ E RF + EA
Sbjct: 326 ----YGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFP-----RTLGPEA 376
Query: 314 KDLIQRLICSRERRLGQNGIEDFK---KHAFFEGLNWENI--RNLEAPYIPDVSSPSDTS 368
K L+ L+ ++ G ED K +H FF G+ W+++ + L P+ P V+S +DT
Sbjct: 377 KSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTR 436
Query: 369 NFDVDDDVLRNTEILPP 385
FD ++ + I PP
Sbjct: 437 YFD-EEFTAQMITITPP 452
>gi|62241011 AKT1 kinase [Homo sapiens]
Length = 480
Score = 201 bits (511), Expect = 5e-51
Identities = 122/317 (38%), Positives = 182/317 (57%), Gaps = 19/317 (5%)
Query: 75 DFEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVLVNGDCQ 134
+FE +K++G+G FG+V +VK K T R YAMKIL K ++ + E A E VL N
Sbjct: 149 EFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHP 208
Query: 135 WITALHYAFQDENHLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFYIGEMVLAIDSIH-Q 193
++TAL Y+FQ + L VM+Y GG+L LS+ E ED ARFY E+V A+D +H +
Sbjct: 209 FLTALKYSFQTHDRLCFVMEYANGGELFFHLSR-ERVFSEDRARFYGAEIVSALDYLHSE 267
Query: 194 LHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVQSSVAVGTPDYISPEILQAMED 253
+ V+RD+K +N++LD +GHI++ DFG C + DG + GTP+Y++PE+L+ +
Sbjct: 268 KNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFC-GTPEYLAPEVLEDND- 325
Query: 254 GMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHEERFQFPSHVTDVSEEA 313
YG DWW LGV MYEM+ G PFY + + + I+ E RF + EA
Sbjct: 326 ----YGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFP-----RTLGPEA 376
Query: 314 KDLIQRLICSRERRLGQNGIEDFK---KHAFFEGLNWENI--RNLEAPYIPDVSSPSDTS 368
K L+ L+ ++ G ED K +H FF G+ W+++ + L P+ P V+S +DT
Sbjct: 377 KSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTR 436
Query: 369 NFDVDDDVLRNTEILPP 385
FD ++ + I PP
Sbjct: 437 YFD-EEFTAQMITITPP 452
>gi|5453976 protein kinase C, theta [Homo sapiens]
Length = 706
Score = 200 bits (509), Expect = 9e-51
Identities = 115/308 (37%), Positives = 178/308 (57%), Gaps = 18/308 (5%)
Query: 68 EMQLHREDFEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFREERDV 127
+++L EDF + K++G+G+FG+V + + K T + +A+K L K +L + C E+ V
Sbjct: 372 QIKLKIEDFILHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRV 431
Query: 128 L-VNGDCQWITALHYAFQDENHLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFYIGEMVL 186
L + + ++T + FQ + +L+ VM+Y GGDL+ + K A FY E++L
Sbjct: 432 LSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCH-KFDLSRATFYAAEIIL 490
Query: 187 AIDSIHQLHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVQSSVAVGTPDYISPE 246
+ +H V+RD+K DN+LLD +GHI++ADFG C K N G +++ GTPDYI+PE
Sbjct: 491 GLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMC-KENMLGDAKTNTFCGTPDYIAPE 549
Query: 247 ILQAMEDGMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHEERFQFPSHV 306
IL KY DWWS GV +YEML G++PF+ + E + H R P +
Sbjct: 550 ILLGQ-----KYNHSVDWWSFGVLLYEMLIGQSPFHGQDEEELF-----HSIRMDNPFYP 599
Query: 307 TDVSEEAKDLIQRL-ICSRERRLGQNGIEDFKKHAFFEGLNWENI--RNLEAPYIPDVSS 363
+ +EAKDL+ +L + E+RLG G D ++H F +NWE + + ++ P+ P V S
Sbjct: 600 RWLEKEAKDLLVKLFVREPEKRLGVRG--DIRQHPLFREINWEELERKEIDPPFRPKVKS 657
Query: 364 PSDTSNFD 371
P D SNFD
Sbjct: 658 PFDCSNFD 665
Score = 52.0 bits (123), Expect = 5e-06
Identities = 20/52 (38%), Positives = 29/52 (55%)
Query: 1026 HQFSIKSFSSPTQCSHCTSLMVGLIRQGYACEVCSFACHVSCKDGAPQVCPI 1077
H+F + ++ SPT C HC +L+ GL RQG C+ C H C+ +C I
Sbjct: 232 HRFKVYNYKSPTFCEHCGTLLWGLARQGLKCDACGMNVHHRCQTKVANLCGI 283
Score = 47.0 bits (110), Expect = 2e-04
Identities = 21/52 (40%), Positives = 26/52 (50%)
Query: 1024 KAHQFSIKSFSSPTQCSHCTSLMVGLIRQGYACEVCSFACHVSCKDGAPQVC 1075
K H+F+ F PT CS C + GL +QGY C C+ A H C D C
Sbjct: 158 KCHEFTATFFPQPTFCSVCHEFVWGLNKQGYQCRQCNAAIHKKCIDKVIAKC 209
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.132 0.379
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 66,666,573
Number of Sequences: 37866
Number of extensions: 3333438
Number of successful extensions: 41475
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1091
Number of HSP's successfully gapped in prelim test: 1704
Number of HSP's that attempted gapping in prelim test: 17297
Number of HSP's gapped (non-prelim): 11531
length of query: 1711
length of database: 18,247,518
effective HSP length: 116
effective length of query: 1595
effective length of database: 13,855,062
effective search space: 22098823890
effective search space used: 22098823890
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.