Search of human proteins with 115511020

Search of human proteins with 115511020

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|115511020 Smg-6 homolog, nonsense mediated mRNA decay factor
[Homo sapiens]
         (1419 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|115511020 Smg-6 homolog, nonsense mediated mRNA decay factor ...  2843   0.0  
gi|42475558 SMG-7 homolog isoform 1 [Homo sapiens]                    100   1e-20
gi|42476070 SMG-7 homolog isoform 2 [Homo sapiens]                    100   1e-20
gi|42476066 SMG-7 homolog isoform 4 [Homo sapiens]                     93   2e-18
gi|187960090 SMG5 homolog nonsense mediated mRNA decay factor [H...    75   3e-13
gi|157502209 hypothetical protein LOC54823 [Homo sapiens]              58   6e-08
gi|157502207 hypothetical protein LOC54823 [Homo sapiens]              58   6e-08
gi|42560244 peptidylprolyl isomerase G [Homo sapiens]                  55   5e-07
gi|48255931 hepatoma-derived growth factor-related protein 2 iso...    52   3e-06
gi|14249158 hepatoma-derived growth factor-related protein 2 iso...    52   3e-06
gi|166235169 PRP38 pre-mRNA processing factor 38 (yeast) domain ...    50   2e-05
gi|125656165 THO complex 2 [Homo sapiens]                              50   2e-05
gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo ...    49   3e-05
gi|195546902 suppressor of Ty 5 homolog isoform b [Homo sapiens]       49   3e-05
gi|195546900 suppressor of Ty 5 homolog isoform a [Homo sapiens]       49   3e-05
gi|161169023 suppressor of Ty 5 homolog isoform a [Homo sapiens]       49   3e-05
gi|20149524 suppressor of Ty 5 homolog isoform a [Homo sapiens]        49   3e-05
gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Hom...    48   8e-05
gi|55741709 RNA binding motif protein 25 [Homo sapiens]                47   1e-04
gi|21361282 splicing factor, arginine/serine-rich 4 [Homo sapiens]     47   1e-04
gi|207113199 erythrocyte membrane protein band 4.1-like 2 isofor...    47   2e-04
gi|207113195 erythrocyte membrane protein band 4.1-like 2 isofor...    47   2e-04
gi|4503579 erythrocyte membrane protein band 4.1-like 2 isoform ...    47   2e-04
gi|239754909 PREDICTED: hypothetical protein [Homo sapiens]            46   2e-04
gi|116089325 splicing factor, arginine/serine-rich 12 isoform a ...    45   5e-04
gi|21040255 splicing factor, arginine/serine-rich 12 isoform b [...    45   5e-04
gi|188536004 zinc finger protein 469 [Homo sapiens]                    45   6e-04
gi|15149465 caldesmon 1 isoform 5 [Homo sapiens]                       45   6e-04
gi|41055989 M-phase phosphoprotein 8 [Homo sapiens]                    44   8e-04
gi|22035679 AT rich interactive domain 4B isoform 2 [Homo sapiens]     44   8e-04

>gi|115511020 Smg-6 homolog, nonsense mediated mRNA decay factor [Homo
            sapiens]
          Length = 1419

 Score = 2843 bits (7371), Expect = 0.0
 Identities = 1419/1419 (100%), Positives = 1419/1419 (100%)

Query: 1    MAEGLERVRISASELRGILATLAPQAGSRENMKELKEARPRKDNRRPDLEIYKPGLSRLR 60
            MAEGLERVRISASELRGILATLAPQAGSRENMKELKEARPRKDNRRPDLEIYKPGLSRLR
Sbjct: 1    MAEGLERVRISASELRGILATLAPQAGSRENMKELKEARPRKDNRRPDLEIYKPGLSRLR 60

Query: 61   NKPKIKEPPGSEEFKDEIVNDRDCSAVENGTQPVKDVCKELNNQEQNGPIDPENNRGQES 120
            NKPKIKEPPGSEEFKDEIVNDRDCSAVENGTQPVKDVCKELNNQEQNGPIDPENNRGQES
Sbjct: 61   NKPKIKEPPGSEEFKDEIVNDRDCSAVENGTQPVKDVCKELNNQEQNGPIDPENNRGQES 120

Query: 121  FPRTAGQEDRSLKIIKRTKKPDLQIYQPGRRLQTVSKESASRVEEEEVLNQVEQLRVEED 180
            FPRTAGQEDRSLKIIKRTKKPDLQIYQPGRRLQTVSKESASRVEEEEVLNQVEQLRVEED
Sbjct: 121  FPRTAGQEDRSLKIIKRTKKPDLQIYQPGRRLQTVSKESASRVEEEEVLNQVEQLRVEED 180

Query: 181  ECRGNVAKEEVANKPDRAEIEKSPGGGRVGAAKGEKGKRMGKGEGVRETHDDPARGRPGS 240
            ECRGNVAKEEVANKPDRAEIEKSPGGGRVGAAKGEKGKRMGKGEGVRETHDDPARGRPGS
Sbjct: 181  ECRGNVAKEEVANKPDRAEIEKSPGGGRVGAAKGEKGKRMGKGEGVRETHDDPARGRPGS 240

Query: 241  AKRYSRSDKRRNRYRTRSTSSAGSNNSAEGAGLTDNGCRRRRQDRTKERPRLKKQVSVSS 300
            AKRYSRSDKRRNRYRTRSTSSAGSNNSAEGAGLTDNGCRRRRQDRTKERPRLKKQVSVSS
Sbjct: 241  AKRYSRSDKRRNRYRTRSTSSAGSNNSAEGAGLTDNGCRRRRQDRTKERPRLKKQVSVSS 300

Query: 301  TDSLDEDRIDEPDGLGPRRSSERKRHLERNWSGRGEGEQKNSAKEYRGTLRVTFDAEAMN 360
            TDSLDEDRIDEPDGLGPRRSSERKRHLERNWSGRGEGEQKNSAKEYRGTLRVTFDAEAMN
Sbjct: 301  TDSLDEDRIDEPDGLGPRRSSERKRHLERNWSGRGEGEQKNSAKEYRGTLRVTFDAEAMN 360

Query: 361  KESPMVRSARDDMDRGKPDKGLSSGGKGSEKQESKNPKQELRGRGRGILILPAHTTLSVN 420
            KESPMVRSARDDMDRGKPDKGLSSGGKGSEKQESKNPKQELRGRGRGILILPAHTTLSVN
Sbjct: 361  KESPMVRSARDDMDRGKPDKGLSSGGKGSEKQESKNPKQELRGRGRGILILPAHTTLSVN 420

Query: 421  SAGSPESAPLGPRLLFGSGSKGSRSWGRGGTTRRLWDPNNPDQKPALKTQTPQLHFLDTD 480
            SAGSPESAPLGPRLLFGSGSKGSRSWGRGGTTRRLWDPNNPDQKPALKTQTPQLHFLDTD
Sbjct: 421  SAGSPESAPLGPRLLFGSGSKGSRSWGRGGTTRRLWDPNNPDQKPALKTQTPQLHFLDTD 480

Query: 481  DEVSPTSWGDSRQAQASYYKFQNSDNPYYYPRTPGPASQYPYTGYNPLQYPVGPTNGVYP 540
            DEVSPTSWGDSRQAQASYYKFQNSDNPYYYPRTPGPASQYPYTGYNPLQYPVGPTNGVYP
Sbjct: 481  DEVSPTSWGDSRQAQASYYKFQNSDNPYYYPRTPGPASQYPYTGYNPLQYPVGPTNGVYP 540

Query: 541  GPYYPGYPTPSGQYVCSPLPTSTMSPEEVEQHMRNLQQQELHRLLRVADNQELQLSNLLS 600
            GPYYPGYPTPSGQYVCSPLPTSTMSPEEVEQHMRNLQQQELHRLLRVADNQELQLSNLLS
Sbjct: 541  GPYYPGYPTPSGQYVCSPLPTSTMSPEEVEQHMRNLQQQELHRLLRVADNQELQLSNLLS 600

Query: 601  RDRISPEGLEKMAQLRAELLQLYERCILLDIEFSDNQNVDQILWKNAFYQVIEKFRQLVK 660
            RDRISPEGLEKMAQLRAELLQLYERCILLDIEFSDNQNVDQILWKNAFYQVIEKFRQLVK
Sbjct: 601  RDRISPEGLEKMAQLRAELLQLYERCILLDIEFSDNQNVDQILWKNAFYQVIEKFRQLVK 660

Query: 661  DPNVENPEQIRNRLLELLDEGSDFFDSLLQKLQVTYKFKLEDYMDGLAIRSKPLRKTVKY 720
            DPNVENPEQIRNRLLELLDEGSDFFDSLLQKLQVTYKFKLEDYMDGLAIRSKPLRKTVKY
Sbjct: 661  DPNVENPEQIRNRLLELLDEGSDFFDSLLQKLQVTYKFKLEDYMDGLAIRSKPLRKTVKY 720

Query: 721  ALISAQRCMICQGDIARYREQASDTANYGKARSWYLKAQHIAPKNGRPYNQLALLAVYTR 780
            ALISAQRCMICQGDIARYREQASDTANYGKARSWYLKAQHIAPKNGRPYNQLALLAVYTR
Sbjct: 721  ALISAQRCMICQGDIARYREQASDTANYGKARSWYLKAQHIAPKNGRPYNQLALLAVYTR 780

Query: 781  RKLDAVYYYMRSLAASNPILTAKESLMSLFEETKRKAEQMEKKQHEEFDLSPDQWRKGKK 840
            RKLDAVYYYMRSLAASNPILTAKESLMSLFEETKRKAEQMEKKQHEEFDLSPDQWRKGKK
Sbjct: 781  RKLDAVYYYMRSLAASNPILTAKESLMSLFEETKRKAEQMEKKQHEEFDLSPDQWRKGKK 840

Query: 841  STFRHVGDDTTRLEIWIHPSHPRSSQGTESGKDSEQENGLGSLSPSDLNKRFILSFLHAH 900
            STFRHVGDDTTRLEIWIHPSHPRSSQGTESGKDSEQENGLGSLSPSDLNKRFILSFLHAH
Sbjct: 841  STFRHVGDDTTRLEIWIHPSHPRSSQGTESGKDSEQENGLGSLSPSDLNKRFILSFLHAH 900

Query: 901  GKLFTRIGMETFPAVAEKVLKEFQVLLQHSPSPIGSTRMLQLMTINMFAVHNSQLKDCFS 960
            GKLFTRIGMETFPAVAEKVLKEFQVLLQHSPSPIGSTRMLQLMTINMFAVHNSQLKDCFS
Sbjct: 901  GKLFTRIGMETFPAVAEKVLKEFQVLLQHSPSPIGSTRMLQLMTINMFAVHNSQLKDCFS 960

Query: 961  EECRSVIQEQAAALGLAMFSLLVRRCTCLLKESAKAQLSSPEDQDDQDDIKVSSFVPDLK 1020
            EECRSVIQEQAAALGLAMFSLLVRRCTCLLKESAKAQLSSPEDQDDQDDIKVSSFVPDLK
Sbjct: 961  EECRSVIQEQAAALGLAMFSLLVRRCTCLLKESAKAQLSSPEDQDDQDDIKVSSFVPDLK 1020

Query: 1021 ELLPSVKVWSDWMLGYPDTWNPPPTSLDLPSHVAVDVWSTLADFCNILTAVNQSEVPLYK 1080
            ELLPSVKVWSDWMLGYPDTWNPPPTSLDLPSHVAVDVWSTLADFCNILTAVNQSEVPLYK
Sbjct: 1021 ELLPSVKVWSDWMLGYPDTWNPPPTSLDLPSHVAVDVWSTLADFCNILTAVNQSEVPLYK 1080

Query: 1081 DPDDDLTLLILEEDRLLSGFVPLLAAPQDPCYVEKTSDKVIAADCKRVTVLKYFLEALCG 1140
            DPDDDLTLLILEEDRLLSGFVPLLAAPQDPCYVEKTSDKVIAADCKRVTVLKYFLEALCG
Sbjct: 1081 DPDDDLTLLILEEDRLLSGFVPLLAAPQDPCYVEKTSDKVIAADCKRVTVLKYFLEALCG 1140

Query: 1141 QEEPLLAFKGGKYVSVAPVPDTMGKEMGSQEGTRLEDEEEDVVIEDFEEDSEAEGSGGED 1200
            QEEPLLAFKGGKYVSVAPVPDTMGKEMGSQEGTRLEDEEEDVVIEDFEEDSEAEGSGGED
Sbjct: 1141 QEEPLLAFKGGKYVSVAPVPDTMGKEMGSQEGTRLEDEEEDVVIEDFEEDSEAEGSGGED 1200

Query: 1201 DIRELRAKKLALARKIAEQQRRQEKIQAVLEDHSQMRQMELEIRPLFLVPDTNGFIDHLA 1260
            DIRELRAKKLALARKIAEQQRRQEKIQAVLEDHSQMRQMELEIRPLFLVPDTNGFIDHLA
Sbjct: 1201 DIRELRAKKLALARKIAEQQRRQEKIQAVLEDHSQMRQMELEIRPLFLVPDTNGFIDHLA 1260

Query: 1261 SLARLLESRKYILVVPLIVINELDGLAKGQETDHRAGGYARVVQEKARKSIEFLEQRFES 1320
            SLARLLESRKYILVVPLIVINELDGLAKGQETDHRAGGYARVVQEKARKSIEFLEQRFES
Sbjct: 1261 SLARLLESRKYILVVPLIVINELDGLAKGQETDHRAGGYARVVQEKARKSIEFLEQRFES 1320

Query: 1321 RDSCLRALTSRGNELESIAFRSEDITGQLGNNDDLILSCCLHYCKDKAKDFMPASKEEPI 1380
            RDSCLRALTSRGNELESIAFRSEDITGQLGNNDDLILSCCLHYCKDKAKDFMPASKEEPI
Sbjct: 1321 RDSCLRALTSRGNELESIAFRSEDITGQLGNNDDLILSCCLHYCKDKAKDFMPASKEEPI 1380

Query: 1381 RLLREVVLLTDDRNLRVKALTRNVPVRDIPAFLTWAQVG 1419
            RLLREVVLLTDDRNLRVKALTRNVPVRDIPAFLTWAQVG
Sbjct: 1381 RLLREVVLLTDDRNLRVKALTRNVPVRDIPAFLTWAQVG 1419


>gi|42475558 SMG-7 homolog isoform 1 [Homo sapiens]
          Length = 1137

 Score =  100 bits (249), Expect = 1e-20
 Identities = 67/243 (27%), Positives = 115/243 (47%), Gaps = 16/243 (6%)

Query: 591 QELQLSNLLSRDRISPE-GLEKMAQLRAELLQLYERCILLDIEFSDNQNVDQILWKNAFY 649
           Q L+ + +L  D    + G  ++   R  L  LY++ ++ D+E++ ++ V+Q LW +AF 
Sbjct: 7   QYLRQAEVLKADMTDSKLGPAEVWTSRQALQDLYQKMLVTDLEYALDKKVEQDLWNHAFK 66

Query: 650 QVIEKFRQLVKDPNVENPEQIRNRLLELLDEGSDFFDSLLQKLQVTYKFKLEDYMDGLAI 709
             I   +   K+    N  +++  L   L+  S F+  LLQ+L   +   L   +    +
Sbjct: 67  NQITTLQGQAKNRANPNRSEVQANLSLFLEAASGFYTQLLQELCTVFNVDLPCRVKSSQL 126

Query: 710 RSKPLRKTVKYALIS---------AQRCMICQGDIARYREQASDTANYGKARSWYLKAQH 760
                ++T   A++           Q C++  GDIARYR Q S      +A S+Y  A  
Sbjct: 127 GIISNKQTHTSAIVKPQSSSCSYICQHCLVHLGDIARYRNQTS------QAESYYRHAAQ 180

Query: 761 IAPKNGRPYNQLALLAVYTRRKLDAVYYYMRSLAASNPILTAKESLMSLFEETKRKAEQM 820
           + P NG+PYNQLA+LA      L  ++YY RS+A   P   A  +L     +     +++
Sbjct: 181 LVPSNGQPYNQLAILASSKGDHLTTIFYYCRSIAVKFPFPAASTNLQKALSKALESRDEV 240

Query: 821 EKK 823
           + K
Sbjct: 241 KTK 243



 Score = 36.6 bits (83), Expect = 0.18
 Identities = 39/147 (26%), Positives = 66/147 (44%), Gaps = 29/147 (19%)

Query: 892  FILSFLHAHGKLFTRIGMETFPAVAEKVLKEFQVLLQHSPSPIGSTRMLQLMTINMFAVH 951
            FI +F+  HG ++    +E    + EK+ ++F+ LL        S +++ +  IN+F +H
Sbjct: 249  FIKAFIKFHGHVYLSKSLEKLSPLREKLEEQFKRLL--FQKAFNSQQLVHVTVINLFQLH 306

Query: 952  NSQLKDCFSEECRSVIQEQAAALG----LAMF-SLLVRRCTCLLKESAKAQLSSPEDQDD 1006
            +  L+D FS E       Q   L     LA+F S L   C C L             Q++
Sbjct: 307  H--LRD-FSNETEQHTYSQDEQLCWTQLLALFMSFLGILCKCPL-------------QNE 350

Query: 1007 QDDIKVSSFVPDLKELLPSVKVWSDWM 1033
              +   +++       LP+VKV  DW+
Sbjct: 351  SQEESYNAYP------LPAVKVSMDWL 371


>gi|42476070 SMG-7 homolog isoform 2 [Homo sapiens]
          Length = 1091

 Score =  100 bits (249), Expect = 1e-20
 Identities = 67/243 (27%), Positives = 115/243 (47%), Gaps = 16/243 (6%)

Query: 591 QELQLSNLLSRDRISPE-GLEKMAQLRAELLQLYERCILLDIEFSDNQNVDQILWKNAFY 649
           Q L+ + +L  D    + G  ++   R  L  LY++ ++ D+E++ ++ V+Q LW +AF 
Sbjct: 7   QYLRQAEVLKADMTDSKLGPAEVWTSRQALQDLYQKMLVTDLEYALDKKVEQDLWNHAFK 66

Query: 650 QVIEKFRQLVKDPNVENPEQIRNRLLELLDEGSDFFDSLLQKLQVTYKFKLEDYMDGLAI 709
             I   +   K+    N  +++  L   L+  S F+  LLQ+L   +   L   +    +
Sbjct: 67  NQITTLQGQAKNRANPNRSEVQANLSLFLEAASGFYTQLLQELCTVFNVDLPCRVKSSQL 126

Query: 710 RSKPLRKTVKYALIS---------AQRCMICQGDIARYREQASDTANYGKARSWYLKAQH 760
                ++T   A++           Q C++  GDIARYR Q S      +A S+Y  A  
Sbjct: 127 GIISNKQTHTSAIVKPQSSSCSYICQHCLVHLGDIARYRNQTS------QAESYYRHAAQ 180

Query: 761 IAPKNGRPYNQLALLAVYTRRKLDAVYYYMRSLAASNPILTAKESLMSLFEETKRKAEQM 820
           + P NG+PYNQLA+LA      L  ++YY RS+A   P   A  +L     +     +++
Sbjct: 181 LVPSNGQPYNQLAILASSKGDHLTTIFYYCRSIAVKFPFPAASTNLQKALSKALESRDEV 240

Query: 821 EKK 823
           + K
Sbjct: 241 KTK 243



 Score = 36.6 bits (83), Expect = 0.18
 Identities = 39/147 (26%), Positives = 66/147 (44%), Gaps = 29/147 (19%)

Query: 892  FILSFLHAHGKLFTRIGMETFPAVAEKVLKEFQVLLQHSPSPIGSTRMLQLMTINMFAVH 951
            FI +F+  HG ++    +E    + EK+ ++F+ LL        S +++ +  IN+F +H
Sbjct: 249  FIKAFIKFHGHVYLSKSLEKLSPLREKLEEQFKRLL--FQKAFNSQQLVHVTVINLFQLH 306

Query: 952  NSQLKDCFSEECRSVIQEQAAALG----LAMF-SLLVRRCTCLLKESAKAQLSSPEDQDD 1006
            +  L+D FS E       Q   L     LA+F S L   C C L             Q++
Sbjct: 307  H--LRD-FSNETEQHTYSQDEQLCWTQLLALFMSFLGILCKCPL-------------QNE 350

Query: 1007 QDDIKVSSFVPDLKELLPSVKVWSDWM 1033
              +   +++       LP+VKV  DW+
Sbjct: 351  SQEESYNAYP------LPAVKVSMDWL 371


>gi|42476066 SMG-7 homolog isoform 4 [Homo sapiens]
          Length = 1049

 Score = 92.8 bits (229), Expect = 2e-18
 Identities = 58/206 (28%), Positives = 98/206 (47%), Gaps = 15/206 (7%)

Query: 627 ILLDIEFSDNQNVDQILWKNAFYQVIEKFRQLVKDPNVENPEQIRNRLLELLDEGSDFFD 686
           ++ D+E++ ++ V+Q LW +AF   I   +   K+    N  +++  L   L+  S F+ 
Sbjct: 2   LVTDLEYALDKKVEQDLWNHAFKNQITTLQGQAKNRANPNRSEVQANLSLFLEAASGFYT 61

Query: 687 SLLQKLQVTYKFKLEDYMDGLAIRSKPLRKTVKYALIS---------AQRCMICQGDIAR 737
            LLQ+L   +   L   +    +     ++T   A++           Q C++  GDIAR
Sbjct: 62  QLLQELCTVFNVDLPCRVKSSQLGIISNKQTHTSAIVKPQSSSCSYICQHCLVHLGDIAR 121

Query: 738 YREQASDTANYGKARSWYLKAQHIAPKNGRPYNQLALLAVYTRRKLDAVYYYMRSLAASN 797
           YR Q S      +A S+Y  A  + P NG+PYNQLA+LA      L  ++YY RS+A   
Sbjct: 122 YRNQTS------QAESYYRHAAQLVPSNGQPYNQLAILASSKGDHLTTIFYYCRSIAVKF 175

Query: 798 PILTAKESLMSLFEETKRKAEQMEKK 823
           P   A  +L     +     ++++ K
Sbjct: 176 PFPAASTNLQKALSKALESRDEVKTK 201



 Score = 36.6 bits (83), Expect = 0.18
 Identities = 39/147 (26%), Positives = 66/147 (44%), Gaps = 29/147 (19%)

Query: 892  FILSFLHAHGKLFTRIGMETFPAVAEKVLKEFQVLLQHSPSPIGSTRMLQLMTINMFAVH 951
            FI +F+  HG ++    +E    + EK+ ++F+ LL        S +++ +  IN+F +H
Sbjct: 207  FIKAFIKFHGHVYLSKSLEKLSPLREKLEEQFKRLL--FQKAFNSQQLVHVTVINLFQLH 264

Query: 952  NSQLKDCFSEECRSVIQEQAAALG----LAMF-SLLVRRCTCLLKESAKAQLSSPEDQDD 1006
            +  L+D FS E       Q   L     LA+F S L   C C L             Q++
Sbjct: 265  H--LRD-FSNETEQHTYSQDEQLCWTQLLALFMSFLGILCKCPL-------------QNE 308

Query: 1007 QDDIKVSSFVPDLKELLPSVKVWSDWM 1033
              +   +++       LP+VKV  DW+
Sbjct: 309  SQEESYNAYP------LPAVKVSMDWL 329


>gi|187960090 SMG5 homolog nonsense mediated mRNA decay factor [Homo
           sapiens]
          Length = 1016

 Score = 75.5 bits (184), Expect = 3e-13
 Identities = 64/281 (22%), Positives = 132/281 (46%), Gaps = 20/281 (7%)

Query: 567 EEVEQHMRNLQQQELHR-LLRVADNQELQLSNLLSRDRI-SPEGLEKMAQLRAELLQLYE 624
           E  E   + L  + L+R ++      +L L N  +   +  PE +    +LR   ++L  
Sbjct: 9   ESSEPEAKVLHTKRLYRAVVEAVHRLDLILCNKTAYQEVFKPENISLRNKLRELCVKLM- 67

Query: 625 RCILLDIEFSDNQNVDQILWKNAFYQVIEKFRQLVKDPNVENPEQIRNRLLELLDEGSDF 684
              L  +++   +  +++LW+  +Y+VI+  +   K  ++ +   +       L  G  F
Sbjct: 68  --FLHPVDYG--RKAEELLWRKVYYEVIQLIKTNKK--HIHSRSTLECAYRTHLVAGIGF 121

Query: 685 FDSLLQKLQVTYKFKLEDYMDGLAIRS------KPLR---KTVKYALISAQRCMICQGDI 735
           +  LL  +Q  Y+ +L+  +D   +        KP+    K + +A ++  RC++  GD+
Sbjct: 122 YQHLLLYIQSHYQLELQCCIDWTHVTDPLIGCKKPVSASGKEMDWAQMACHRCLVYLGDL 181

Query: 736 ARYREQASDTANYGKARSWYLKAQHIAPKNGRPYNQLALLAVYTRRKLDAVYYYMRSLAA 795
           +RY+ + +       A  +Y +A  +AP+ G P+NQL  LA      ++A+Y Y+R + +
Sbjct: 182 SRYQNELAGVDTELLAERFYYQALSVAPQIGMPFNQLGTLAGSKYYNVEAMYCYLRCIQS 241

Query: 796 SNPILTAKESLMSLFEETKRKAEQMEKKQHEEFDLSPDQWR 836
                 A  +L  L+++  +   Q++K +  +  LSP + R
Sbjct: 242 EVSFEGAYGNLKRLYDKAAKMYHQLKKCETRK--LSPGKKR 280



 Score = 59.7 bits (143), Expect = 2e-08
 Identities = 132/577 (22%), Positives = 228/577 (39%), Gaps = 103/577 (17%)

Query: 812  ETKRKAEQMEKKQHEEFDLSPD--QWRKGKKSTF-------RH---VGDDTTRLEIWIHP 859
            E+K   E+ E+   E   ++P   + RK +K +        RH   VGDD+   E +   
Sbjct: 422  ESKEPVEKEEEPDPEPPPVTPQVGEGRKSRKFSRLSCLRRRRHPPKVGDDSDLSEGFESD 481

Query: 860  SH---PRSSQGTESGKDSEQENG---LGSLSPSDLNKRFILSFLH-AHGKLFTRIGMETF 912
            S     R+S+G++SG D   E G     + + S++N +   S L     +  TR      
Sbjct: 482  SSHDSARASEGSDSGSDKSLEGGGTAFDAETDSEMNSQESRSDLEDMEEEEGTRSPTLEP 541

Query: 913  PAVAEKVLKEFQVLLQHSPSPIGSTRMLQLMTINMFAVHNSQLKDCFSEE---CRSVIQE 969
            P    +        L  S + I S   LQ M+  MF     Q K CF         ++Q 
Sbjct: 542  PRGRSEAPDSLNGPLGPSEASIASN--LQAMSTQMF-----QTKRCFRLAPTFSNLLLQP 594

Query: 970  QAAALGLAMFSLLVRRCTCLLKESAKAQLSSPEDQD-------DQDDIKVSSFVPDLKEL 1022
                   A     V        E A  + S  E  +       ++  I+    V   + L
Sbjct: 595  TTNPHTSASHRPCVNGDVDKPSEPASEEGSESEGSESSGRSCRNERSIQEKLQVLMAEGL 654

Query: 1023 LPSVKVWSDWMLGYPDTWNPPPTSLDLPSHVAVDVWSTLADFCNILTA---VNQSEVPLY 1079
            LP+VKV+ DW+   PD        + + +  +  +W+ L+   N+L A   + +S + L 
Sbjct: 655  LPAVKVFLDWLRTNPDL-------IIVCAQSSQSLWNRLSVLLNLLPAAGELQESGLALC 707

Query: 1080 KDPDDDL---------TLLILEEDRLLSGFVPLLAAPQDPCY-VEKTSDKVIAADCKRVT 1129
             +  D L         + L+L ED  L    PL AA +   +  ++     +     R+ 
Sbjct: 708  PEVQDLLEGCELPDLPSSLLLPEDMALRNLPPLRAAHRRFNFDTDRPLLSTLEESVVRIC 767

Query: 1130 VLKYFLEALCGQEEPLLAF--KGGKYVSVAPVPDTMGKEMGSQEGTRLEDEEEDVVIEDF 1187
             ++ F   +   +  +L F  + G +VS+A                  + E+E ++    
Sbjct: 768  CIRSFGHFIARLQGSILQFNPEVGIFVSIA------------------QSEQESLL---- 805

Query: 1188 EEDSEAEGSGGEDDIRELRAKKLALARKIAEQQRRQEKIQAVLEDHSQMRQMELEIRPLF 1247
             + ++A+    +++ R  R     L R +A+ + + E  Q  LE   Q  + +  + P +
Sbjct: 806  -QQAQAQFRMAQEEARRNR-----LMRDMAQLRLQLEVSQ--LEGSLQQPKAQSAMSP-Y 856

Query: 1248 LVPDTNGFIDHLASLARLLESRKYILVVPLIVINELDGLAKGQETDHRAGGYARVVQEKA 1307
            LVPDT     HL  + +L  S ++I+++P  VI+ LD L K    +H            A
Sbjct: 857  LVPDTQALCHHLPVIRQLATSGRFIVIIPRTVIDGLDLLKK----EHPG----------A 902

Query: 1308 RKSIEFLEQRFESRDSCLRALTSRGNELESIAFRSED 1344
            R  I +LE  F+  +  +R     G   E    + +D
Sbjct: 903  RDGIRYLEAEFKKGNRYIRCQKEVGKSFERHKLKRQD 939



 Score = 33.5 bits (75), Expect = 1.5
 Identities = 44/169 (26%), Positives = 66/169 (39%), Gaps = 16/169 (9%)

Query: 162 RVEEEEVLNQVEQLR---VEEDECRGNVAKEEVANKPDRAEIEKSPGGGRVGAAKGEKGK 218
           + E EE  N V   +    +E E +  V KEE   +PD    E  P   +VG  +G K +
Sbjct: 400 QAELEEGENPVPAFQSDGTDEPESKEPVEKEE---EPDP---EPPPVTPQVG--EGRKSR 451

Query: 219 RMGKGEGVRETHDDPARGRPGSAKRYSRSDKRRNRYRTRSTSSAGSNNSAEGAGLTDNGC 278
           +  +   +R     P  G          SD   +  R    S +GS+ S EG G   +  
Sbjct: 452 KFSRLSCLRRRRHPPKVGDDSDLSEGFESDSSHDSARASEGSDSGSDKSLEGGGTAFDAE 511

Query: 279 RRRRQDRTKERPRL----KKQVSVSSTDSLDEDRIDEPDGL-GPRRSSE 322
                +  + R  L    +++ + S T      R + PD L GP   SE
Sbjct: 512 TDSEMNSQESRSDLEDMEEEEGTRSPTLEPPRGRSEAPDSLNGPLGPSE 560


>gi|157502209 hypothetical protein LOC54823 [Homo sapiens]
          Length = 900

 Score = 58.2 bits (139), Expect = 6e-08
 Identities = 50/168 (29%), Positives = 78/168 (46%), Gaps = 38/168 (22%)

Query: 1244 RPLFLVPDTNGFIDHLASLARLLESR------KYILVVPLIVINELDGLAKGQETDHRAG 1297
            R L +V DTN  ++HL    R+L++       K +L++P +V+ ELD + +G+       
Sbjct: 386  RKLLIVIDTNILMNHL-KFVRILKTTEVPGFDKLVLIIPWVVMQELDRMKEGK------- 437

Query: 1298 GYARVVQEKARKSIEFLEQRFESRDSCLRALTSRGNELESIAFRSEDITGQLG-NNDDLI 1356
               +  Q KA  ++ F+    +++D  L          +SI   S+   G    NNDD +
Sbjct: 438  -LLKRAQHKAIPAVHFINDSLKNQDRKLWG--------QSIQLASQKHYGLSDENNDDRV 488

Query: 1357 LSCCLHYCKDKAKDFMPASKEEPIRLLREVVLLTDDRNLRVKALTRNV 1404
            L CCL +     ++  P S          V+L TDDRNLR K L   V
Sbjct: 489  LKCCLQH-----QELFPCSF---------VILCTDDRNLRNKGLISGV 522


>gi|157502207 hypothetical protein LOC54823 [Homo sapiens]
          Length = 900

 Score = 58.2 bits (139), Expect = 6e-08
 Identities = 50/168 (29%), Positives = 78/168 (46%), Gaps = 38/168 (22%)

Query: 1244 RPLFLVPDTNGFIDHLASLARLLESR------KYILVVPLIVINELDGLAKGQETDHRAG 1297
            R L +V DTN  ++HL    R+L++       K +L++P +V+ ELD + +G+       
Sbjct: 386  RKLLIVIDTNILMNHL-KFVRILKTTEVPGFDKLVLIIPWVVMQELDRMKEGK------- 437

Query: 1298 GYARVVQEKARKSIEFLEQRFESRDSCLRALTSRGNELESIAFRSEDITGQLG-NNDDLI 1356
               +  Q KA  ++ F+    +++D  L          +SI   S+   G    NNDD +
Sbjct: 438  -LLKRAQHKAIPAVHFINDSLKNQDRKLWG--------QSIQLASQKHYGLSDENNDDRV 488

Query: 1357 LSCCLHYCKDKAKDFMPASKEEPIRLLREVVLLTDDRNLRVKALTRNV 1404
            L CCL +     ++  P S          V+L TDDRNLR K L   V
Sbjct: 489  LKCCLQH-----QELFPCSF---------VILCTDDRNLRNKGLISGV 522


>gi|42560244 peptidylprolyl isomerase G [Homo sapiens]
          Length = 754

 Score = 55.1 bits (131), Expect = 5e-07
 Identities = 75/403 (18%), Positives = 155/403 (38%), Gaps = 43/403 (10%)

Query: 6   ERVRISASELRGILATLAPQAGSRENMKELKEARPRKDNRRPDLEIYKPGLSRLRNKPKI 65
           +R+R+S+ E R I        G +  + E+KE      N+R  + + +  ++  RN   +
Sbjct: 370 QRMRVSSGE-RWI-------KGDKSELNEIKE------NQRSPVRVKERKITDHRN---V 412

Query: 66  KEPPGSEEFKDEIVNDRDCSAVENGTQPVKDVCKELNNQ------EQNGPIDPENNRGQE 119
            E P  +  K++ V D   ++ E   +   +   +  N+       ++     E ++ +E
Sbjct: 413 SESPNRKNEKEKKVKDHKSNSKERDIRRNSEKDDKYKNKVKKRAKSKSRSKSKEKSKSKE 472

Query: 120 SFPRTAGQEDRSLKIIKRTKKPDLQIYQPGRRLQTVSKESASRVEEEEVLNQVEQLRVEE 179
              +    E++ ++   R+K  D +  +   +      +   R   +E   Q+E    E 
Sbjct: 473 RDSKHNRNEEKRMR--SRSKGRDHENVKEKEKQSDSKGKDQERSRSKEKSKQLESKSNEH 530

Query: 180 DECRGNVAKEEVANKPDRAEIEKSPGGGRVGAAKGEKGKRMGKGEGVRETHDDPARGRPG 239
           D  +         ++    +I K  G     +   E+ +   +   VR    D  R R  
Sbjct: 531 DHSKSKEKDRRAQSRSRECDITK--GKHSYNSRTRERSRSRDRSRRVRSRTHDRDRSRSK 588

Query: 240 SAKRYSRSDKRRNRYRTRSTSSAGSNNSAEGAGLTDNGCRRRRQDRTKERPRLKKQVSVS 299
              RY     R   YR R  S +    +  G   + +  RRRR  R+ ER         S
Sbjct: 589 EYHRY-----REQEYRRRGRSRSRERRTPPGRSRSKDRRRRRRDSRSSEREE-------S 636

Query: 300 STDSLDEDRIDEPDGLGPRRSSERKRHL---ERNWSGRGEGEQKNSAKEYRGTLRVTFDA 356
            + + D+ R  E      + +SE ++ +    R+ +      +K + ++     ++   +
Sbjct: 637 QSRNKDKYRNQESKSSHRKENSESEKRMYSKSRDHNSSNNSREKKADRDQSPFSKIKQSS 696

Query: 357 EAMNKESPMVRSARDDMDRGKPDK-GLSSGGKGSEKQESKNPK 398
           +    +S M+++  D+  R   +K    S G+ ++    KN K
Sbjct: 697 QDNELKSSMLKNKEDEKIRSSVEKENQKSKGQENDHVHEKNKK 739


>gi|48255931 hepatoma-derived growth factor-related protein 2
           isoform 1 [Homo sapiens]
          Length = 671

 Score = 52.4 bits (124), Expect = 3e-06
 Identities = 63/246 (25%), Positives = 101/246 (41%), Gaps = 37/246 (15%)

Query: 169 LNQVEQLRVEEDECRGNVAKEEVANK---PDRAEIEKSPGGGRVGAAKGEKGKRMGKGEG 225
           L+Q      EE+    +   E+ +++   P++    ++P  G +G  K +K       + 
Sbjct: 177 LDQASVSPSEEENSESSSESEKTSDQDFTPEKKAAVRAPRRGPLGGRKKKKAPSASDSDS 236

Query: 226 VRETHDDPARGRPGSAKRYSRSDKRRNRYRTRSTSSAGSNNSAEGAGLTDNGCRRRRQDR 285
             ++  D A+  P +  R + S          S+SS+ S++S         G +   +  
Sbjct: 237 KADS--DGAKPEPVAMARSASS----------SSSSSSSSDSDVSVKKPPRGRKPAEKPL 284

Query: 286 TKERPRLKKQVSVSSTDSLDEDRIDEPDGLGP--RRSSERKRHLERNWSGRGEGEQKNSA 343
            K R R  K     S+ S D D  DE D +    RR   R+R LE     R   EQ+   
Sbjct: 285 PKPRGRKPKPERPPSSSSSDSDS-DEVDRISEWKRRDEARRRELE----ARRRREQEEEL 339

Query: 344 KEYRGTLRVTFDAEAMNKESPMVRSARDDMDRGKPDKGLSSGGKGSEKQESKNP--KQEL 401
           +  R       + E   KE       R+  DRG+ ++G S G  G E +E   P  K+  
Sbjct: 340 RRLR-------EQEKEEKER-----RRERADRGEAERG-SGGSSGDELREDDEPVKKRGR 386

Query: 402 RGRGRG 407
           +GRGRG
Sbjct: 387 KGRGRG 392


>gi|14249158 hepatoma-derived growth factor-related protein 2
           isoform 2 [Homo sapiens]
          Length = 670

 Score = 52.4 bits (124), Expect = 3e-06
 Identities = 63/246 (25%), Positives = 101/246 (41%), Gaps = 37/246 (15%)

Query: 169 LNQVEQLRVEEDECRGNVAKEEVANK---PDRAEIEKSPGGGRVGAAKGEKGKRMGKGEG 225
           L+Q      EE+    +   E+ +++   P++    ++P  G +G  K +K       + 
Sbjct: 177 LDQASVSPSEEENSESSSESEKTSDQDFTPEKKAAVRAPRRGPLGGRKKKKAPSASDSDS 236

Query: 226 VRETHDDPARGRPGSAKRYSRSDKRRNRYRTRSTSSAGSNNSAEGAGLTDNGCRRRRQDR 285
             ++  D A+  P +  R + S          S+SS+ S++S         G +   +  
Sbjct: 237 KADS--DGAKPEPVAMARSASS----------SSSSSSSSDSDVSVKKPPRGRKPAEKPL 284

Query: 286 TKERPRLKKQVSVSSTDSLDEDRIDEPDGLGP--RRSSERKRHLERNWSGRGEGEQKNSA 343
            K R R  K     S+ S D D  DE D +    RR   R+R LE     R   EQ+   
Sbjct: 285 PKPRGRKPKPERPPSSSSSDSDS-DEVDRISEWKRRDEARRRELE----ARRRREQEEEL 339

Query: 344 KEYRGTLRVTFDAEAMNKESPMVRSARDDMDRGKPDKGLSSGGKGSEKQESKNP--KQEL 401
           +  R       + E   KE       R+  DRG+ ++G S G  G E +E   P  K+  
Sbjct: 340 RRLR-------EQEKEEKER-----RRERADRGEAERG-SGGSSGDELREDDEPVKKRGR 386

Query: 402 RGRGRG 407
           +GRGRG
Sbjct: 387 KGRGRG 392



 Score = 36.2 bits (82), Expect = 0.23
 Identities = 58/259 (22%), Positives = 100/259 (38%), Gaps = 43/259 (16%)

Query: 25  QAGSRENMKELKEARPRKDNRRPDLEIYKPGLSRLRNKPKIKEPPGSEEFKDEIVNDRDC 84
           Q   R   +E ++A+P K  R         G S  R   K KEP   E+ +      +  
Sbjct: 429 QKEKRVRPEEKQQAKPVKVERTRKRS---EGFSMDRKVEKKKEPSVEEKLQKLHSEIKFA 485

Query: 85  SAVENGTQPVKDVCKELNNQEQNGPIDPENNRGQESFPRTAG-QEDRSLKIIKRTKKPDL 143
             V++      DV + LN  E+ G +   +   Q++    A  ++ R  K  K   +   
Sbjct: 486 LKVDS-----PDVKRCLNALEELGTLQVTSQILQKNTDVVATLKKIRRYKANKDVMEKAA 540

Query: 144 QIYQP------GRRLQTVSKESASRVEEEEVLNQVEQLRVEEDECRGNVAKEEVANKPDR 197
           ++Y        G +++ V K + + +E+E+      + ++  +E  G  A +E A     
Sbjct: 541 EVYTRLKSRVLGPKIEAVQKVNKAGMEKEKA-----EEKLAGEELAGEEAPQEKAEDKPS 595

Query: 198 AEIEKSPGGGRVGAAKGE--------------KGKRMGKGEGVRETHDDPARGRPGSAKR 243
            ++  +P  G   + KGE              +G R G  E + +  + P   RPGS   
Sbjct: 596 TDLS-APVNGEATSQKGESAEDKEHEEGRDSEEGPRCGSSEDLHDVREGPDLDRPGS--- 651

Query: 244 YSRSDKRRNRYRTRSTSSA 262
                 R+ R R R  S A
Sbjct: 652 -----DRQERERARGDSEA 665


>gi|166235169 PRP38 pre-mRNA processing factor 38 (yeast) domain
           containing B [Homo sapiens]
          Length = 546

 Score = 50.1 bits (118), Expect = 2e-05
 Identities = 63/312 (20%), Positives = 126/312 (40%), Gaps = 23/312 (7%)

Query: 29  RENMKELKEARPRKDNRRPDLEIY-KPGLSRLRNKPKIKEPPGSEEFKDEIVNDRDCSAV 87
           +E  +E+     R+ +R P   +  +    R R++   +E  GS  F  E+  +++   +
Sbjct: 245 KEGAEEIDRHVERRRSRSPRRSLSPRRSPRRSRSRSHHREGHGSSSFDRELEREKERQRL 304

Query: 88  ENGTQPVKDVCKELNNQEQ-NGPIDPENNRGQESFPRTAGQEDRSLKIIKRTKKPDLQIY 146
           E   +  K+  KE       +  ++   +R +E     +   DR      R ++ + +  
Sbjct: 305 E---REAKEREKERRRSRSIDRGLERRRSRSRERHRSRSRSRDRKGDRRDRDREREKENE 361

Query: 147 QPGRRLQTVSKESASRVEEEEVLNQVEQLRVEEDECRGNVAKEEVANKPDRAEIEKSPGG 206
           +  RR +   KE  +  E+E    +  + R +E   RG V  EE  +K D+ +       
Sbjct: 362 RGRRRDRDYDKERGNEREKER---ERSRERSKEQRSRGEV--EEKKHKEDKDDRRH---- 412

Query: 207 GRVGAAKGEKGKRMGKGEGVRETHDDPARGRPGSAKRYSRSDKRRNRYRTRSTSSAGSNN 266
            R      +K K+  +       H   +R R    +  SRS ++ ++++  S   +   +
Sbjct: 413 -RDDKRDSKKEKKHSRSRSRERKHRSRSRSRNAGKRSRSRSKEKSSKHKNESKEKSNKRS 471

Query: 267 SAEGAGLTDN--GCRRRRQDRTKERPRLKKQVSVSSTDSLDEDRIDEPDGLGPRRS---- 320
            +   G TD+    ++R    +KE+ R + +    S      D  D+ D    RRS    
Sbjct: 472 RSGSQGRTDSVEKSKKREHSPSKEKSRKRSRSKERSHKRDHSDSKDQSDKHDRRRSQSIE 531

Query: 321 --SERKRHLERN 330
             S+ K+H  ++
Sbjct: 532 QESQEKQHKNKD 543



 Score = 42.0 bits (97), Expect = 0.004
 Identities = 50/186 (26%), Positives = 68/186 (36%), Gaps = 23/186 (12%)

Query: 224 EGVRETHDDPARGRPGSAKRYSRSDKRRNRYRTRSTSSAGSNNSAEGAGLTDNGCRRRRQ 283
           EG   +  D    R    +R  R  K R + R RS S              D G  RRR 
Sbjct: 284 EGHGSSSFDRELEREKERQRLEREAKEREKERRRSRS-------------IDRGLERRRS 330

Query: 284 DRTKERPRLKKQVSVSSTDSLDEDRIDEPDGLGPRRSSERKRHLERNWSGRGEGEQKNS- 342
            R++ER R + +      D  D DR  E +     R   R R  ++      E E++ S 
Sbjct: 331 -RSRERHRSRSRSRDRKGDRRDRDREREKEN---ERGRRRDRDYDKERGNEREKERERSR 386

Query: 343 --AKEYRGTLRVTFDAEAMNKESPMVRSARDDMDRGKPDKGLSSGGKGSEKQESKNPKQE 400
             +KE R    V    E  +KE    R  RDD    K +K  S       K  S++  + 
Sbjct: 387 ERSKEQRSRGEVE---EKKHKEDKDDRRHRDDKRDSKKEKKHSRSRSRERKHRSRSRSRN 443

Query: 401 LRGRGR 406
              R R
Sbjct: 444 AGKRSR 449



 Score = 38.5 bits (88), Expect = 0.046
 Identities = 62/285 (21%), Positives = 102/285 (35%), Gaps = 35/285 (12%)

Query: 139 KKPDLQIYQPGRRLQTVSKESASRVEEEEVLNQVEQLRVEEDECRGNVAKEEVANKPDRA 198
           K  D QI    R+++   KE A     EE+   VE+ R      R    +        R+
Sbjct: 227 KNIDQQIKTRPRKIKKDGKEGA-----EEIDRHVERRRSRSPR-RSLSPRRSPRRSRSRS 280

Query: 199 EIEKSPGGGRVGAAKGEKGKRMGKGEGVRETHDDPARGRP---GSAKRYSRSDKR-RNRY 254
              +  G          + +R       +E   +  R R    G  +R SRS +R R+R 
Sbjct: 281 HHREGHGSSSFDRELEREKERQRLEREAKEREKERRRSRSIDRGLERRRSRSRERHRSRS 340

Query: 255 RTRSTSSAGSNNSAEGAGLTDNGCRR-----------RRQDRTKERPRLKKQVSVSSTDS 303
           R+R       +   E     + G RR           R ++R + R R K+Q S    + 
Sbjct: 341 RSRDRKGDRRDRDREREKENERGRRRDRDYDKERGNEREKERERSRERSKEQRSRGEVEE 400

Query: 304 L------------DEDRIDEPDGLGPRRSSERKRHLERNWSGRGEGEQKNSAKEYRGTLR 351
                        D+ R  + +    R  S  ++H  R+ S R  G++  S  + + +  
Sbjct: 401 KKHKEDKDDRRHRDDKRDSKKEKKHSRSRSRERKHRSRSRS-RNAGKRSRSRSKEKSSKH 459

Query: 352 VTFDAEAMNKESPMVRSAR-DDMDRGKPDKGLSSGGKGSEKQESK 395
                E  NK S      R D +++ K  +   S  K  ++  SK
Sbjct: 460 KNESKEKSNKRSRSGSQGRTDSVEKSKKREHSPSKEKSRKRSRSK 504


>gi|125656165 THO complex 2 [Homo sapiens]
          Length = 1593

 Score = 49.7 bits (117), Expect = 2e-05
 Identities = 69/332 (20%), Positives = 132/332 (39%), Gaps = 48/332 (14%)

Query: 29   RENMKELKEARPRKDNRRPDLEIYKPGLSRLRNKPKIKEPPGSEEFKDEIVNDRDCSAVE 88
            ++  ++ KE RP KD +  + +   P   + + K K +E    E+FK  + N    S  E
Sbjct: 1297 KDGKEKPKEERPNKDEKARETKERTPKSDKEKEKFKKEEKAKDEKFKTTVPNAESKSTQE 1356

Query: 89   NGTQP----VKDVCKELNNQEQNGPIDPENNRGQESFPRTAGQEDRSLKI-IKRTKKPDL 143
               +      +D+ KE+ ++        EN +G E  P +      SLK  + R+  P+ 
Sbjct: 1357 REREKEPSRERDIAKEMKSK--------ENVKGGEKTPVSG-----SLKSPVPRSDIPEP 1403

Query: 144  QIYQPGRRLQTVSKESASRVEEEEVLNQVE---QLRVEEDECRGNVAKEEVANKPDRAEI 200
            +  Q  R++ T    S S   ++ ++   E   +L +       + +KE    + D+ ++
Sbjct: 1404 EREQKRRKIDTHPSPSHSSTVKDSLIELKESSAKLYINHTPPPLSKSKE---REMDKKDL 1460

Query: 201  EKSPGGGRVGAAKGEKGKRMGKGEGVRETHDDPARGRPGSAKRYSRSDKRRNRYRTRSTS 260
            +KS    R    K EK ++  K +      + P    P   KR      R+    T   S
Sbjct: 1461 DKSRERSREREKKDEKDRKERKRDHSNNDREVP----PDLTKR------RKEENGTMGVS 1510

Query: 261  SAGSNNSAEGAGLTDNGCRRRRQDRTKERPRLKKQVSVSSTDSLDEDRIDEPDGLGPRRS 320
               S +  E              ++ KE+ + K       +DS   +++D+    G + S
Sbjct: 1511 KHKSESPCESP---------YPNEKDKEKNKSKSSGKEKGSDSFKSEKMDKISSGGKKES 1561

Query: 321  SERKRHLER-----NWSGRGEGEQKNSAKEYR 347
               K  +E+     +  G+ E +   S+ ++R
Sbjct: 1562 RHDKEKIEKKEKRDSSGGKEEKKHHKSSDKHR 1593



 Score = 31.6 bits (70), Expect = 5.7
 Identities = 36/198 (18%), Positives = 77/198 (38%), Gaps = 20/198 (10%)

Query: 198  AEIEKSPGGGRVGAAKGEKGKRMGKGEGVRETHDDPARGRPGSAKRYSRSDKRRNRYRTR 257
            A ++  PGGG   ++ G   K         ET     R + G  K  +++          
Sbjct: 1198 ASVQNGPGGGPSSSSIGSASK--SDESSTEETDKSRERSQCG-VKAVNKAS--------- 1245

Query: 258  STSSAGSNNSAEGAGLTDNGCRRRRQDRTKERPRLKKQVSVSSTDS---LDEDRIDEPDG 314
            ST+  G++++      ++   +   +++ KE+ + KK+ + ++T     L +D  ++P  
Sbjct: 1246 STTPKGNSSNGNSGSNSNKAVKENDKEKGKEKEKEKKEKTPATTPEARVLGKDGKEKPKE 1305

Query: 315  LGPRRSSERKRHLERNWSGRGE-----GEQKNSAKEYRGTLRVTFDAEAMNKESPMVRSA 369
              P +  + +   ER      E      E+K   ++++ T+          +E     S 
Sbjct: 1306 ERPNKDEKARETKERTPKSDKEKEKFKKEEKAKDEKFKTTVPNAESKSTQEREREKEPSR 1365

Query: 370  RDDMDRGKPDKGLSSGGK 387
              D+ +    K    GG+
Sbjct: 1366 ERDIAKEMKSKENVKGGE 1383


>gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo
           sapiens]
          Length = 600

 Score = 49.3 bits (116), Expect = 3e-05
 Identities = 94/446 (21%), Positives = 156/446 (34%), Gaps = 49/446 (10%)

Query: 29  RENMKELKEARPRKDNRRPDLEIYKPGLSRLRNKPKIKEPPGSEEFKDEIVNDRDCSA-V 87
           R+  +E KE   +K+  R      + G  R  +  + +E     E + E   DR+     
Sbjct: 113 RDRQRE-KERNRQKERERETEREGERGRDRQTDGQRERERQRDAEKERERQTDRERQRQT 171

Query: 88  ENGTQPVKDVCKELNNQEQNGPIDPENNRGQESFPRTAGQEDRSLKIIKRTKKPDLQIYQ 147
           E   Q  ++  +E N QE+      E  R +E   +T   EDR  +  +  ++      +
Sbjct: 172 ERNRQKERE--REKNRQERR-----ERERQREKENKT---EDRHSERGRERERERETETE 221

Query: 148 PGRRLQTVSKESASRVEEEEVLNQVEQLRVEEDECRGNVAKEEVANKP---DRAEIEKSP 204
             R+ QT  +    R  E E   Q E+ R  E E   +  +E   ++    DR + E+  
Sbjct: 222 TERKRQTDRERDRQRKTEREREKQAERERASERETERDKERERERDRDRDRDRRQKERER 281

Query: 205 GGGRVGAAKGEKGK-----------RMGKGEGVRETHDDPARGRPGSAKRYSRSDKRRNR 253
              R    + E+ +           R  + E  R+   +  R R    +R +  D+ + R
Sbjct: 282 QTDRKRQRRTERDRETERKRERQRERERERERNRKRERERERERERERQRETERDREKER 341

Query: 254 YRTRSTSSAGSNNSAEGAGLTDNGCRRRRQDRTKERPRLKKQVSVSSTDSLDEDRIDEPD 313
            R R   +          G        R ++R +ER R   +         D D      
Sbjct: 342 ERKRKRQTEMDRERNRQTGREGRRQAERERERERERDRQSAREREERERDRDRD------ 395

Query: 314 GLGPRRSSERKRHLERNWSGRGEGEQKNSAKEYRGTLRVTFDAEAMNKESPMVRSARDDM 373
                R  ER+R  E++  G+ E E++   ++ R + R         K+    R      
Sbjct: 396 -----RQKERERQTEKDRDGQRETEKQREREKDRESERGRERGREREKQKGRERDRERQT 450

Query: 374 DRGKPDKGLSSGGKGSEKQESKNPKQELRGRGRGILILPAHTTLSVNSAGSPES-APLGP 432
           DR        +G +        NP      R   +   P   T  +    SPE       
Sbjct: 451 DR-------QAGRQRKRSTLYVNPPPR-TARSGVVQSDPNRPTRGIRWKSSPEDPKAAST 502

Query: 433 RLLFGSGSKGSRSWGRGGTTRRLWDP 458
           R  +G  +K SR    G   RR W+P
Sbjct: 503 RFPWGRPAKASRGRVAG---RRRWEP 525



 Score = 37.0 bits (84), Expect = 0.14
 Identities = 66/322 (20%), Positives = 114/322 (35%), Gaps = 39/322 (12%)

Query: 111 DPENNRGQESFPRTAGQEDRSLKIIKRTKKPDLQIYQPGRRLQTVSKESASRVEEEEVLN 170
           D E NR +E   R   ++       KR ++ +   ++   R          R  E+E   
Sbjct: 53  DRERNRQKERERRREKRQTERETDRKRERRREKDRHRKRDR-----HRERQRDREKERER 107

Query: 171 QVEQLRVEEDECRGNVAKEEVANKPDRAEIEKSPGGGRVGAAKGEKGK-RMGKGEGVRET 229
           Q ++ R  + E      KE    K    E E+    GR     G++ + R    E  RE 
Sbjct: 108 QTDRERDRQRE------KERNRQKERERETEREGERGRDRQTDGQRERERQRDAEKERER 161

Query: 230 HDDPARGRPGSAKRYSRSDKRRNRYRTRST--------------SSAGSNNSAEGAGLTD 275
             D  R R     R    ++ +NR   R                S  G     E    T+
Sbjct: 162 QTDRERQRQTERNRQKEREREKNRQERRERERQREKENKTEDRHSERGRERERERETETE 221

Query: 276 NGCRR---------RRQDRTKERPRLKKQVSVSSTDSLDEDRIDE--PDGLGPRRSSERK 324
              +R         R+ +R +E+   +++ S   T+  D++R  E   D    RR  ER+
Sbjct: 222 TERKRQTDRERDRQRKTEREREKQAERERASERETER-DKERERERDRDRDRDRRQKERE 280

Query: 325 RHLERNWSGRGEGEQKNSAKEYRGTLRVTFDAEAMNKESPMVRSARDDMDRGKPDKGLSS 384
           R  +R    R E +++   K  R   R         +E    R    +  R + ++    
Sbjct: 281 RQTDRKRQRRTERDRETERKRERQRERERERERNRKRERERERERERERQR-ETERDREK 339

Query: 385 GGKGSEKQESKNPKQELRGRGR 406
             +   K++++  ++  R  GR
Sbjct: 340 ERERKRKRQTEMDRERNRQTGR 361


>gi|195546902 suppressor of Ty 5 homolog isoform b [Homo sapiens]
          Length = 1083

 Score = 48.9 bits (115), Expect = 3e-05
 Identities = 34/117 (29%), Positives = 52/117 (44%), Gaps = 13/117 (11%)

Query: 442 GSRSWGRGGTTRRLWDPNNPDQKPALKTQTPQLHFLDTDDEVSPTSWGDSRQAQASYYKF 501
           GSR+  + G     WDPNNP+     + +    +  D +   SP ++G +   Q   Y  
Sbjct: 807 GSRTPAQSGA----WDPNNPNTPS--RAEEEYEYAFDDEPTPSPQAYGGTPNPQTPGYPD 860

Query: 502 QNSD--NPYYYPRTPGPASQYPYTGYNPLQYPVGPTNGVYPGP----YYPGYPTPSG 552
            +S   NP Y P+TPG  + Y    ++P   P  P     P P    Y+   P+P+G
Sbjct: 861 PSSPQVNPQYNPQTPGTPAMYNTDQFSPYAAP-SPQGSYQPSPSPQSYHQVAPSPAG 916



 Score = 37.0 bits (84), Expect = 0.14
 Identities = 35/109 (32%), Positives = 49/109 (44%), Gaps = 22/109 (20%)

Query: 457 DPNNPDQKPALKTQTPQLHFLDTDDEVSPT-------SWGDSRQAQASYYK-------FQ 502
           DP++P   P    QTP    +   D+ SP        S+  S   Q SY++       +Q
Sbjct: 860 DPSSPQVNPQYNPQTPGTPAMYNTDQFSPYAAPSPQGSYQPSPSPQ-SYHQVAPSPAGYQ 918

Query: 503 NSDNPYYYPRTPGP----ASQYPY-TGYNPLQYPVGPTNGVYPGPYYPG 546
           N+ +P  Y  TP P    AS  P   GY+P+  P  P+ G Y  P+ PG
Sbjct: 919 NTHSPASYHPTPSPMAYQASPSPSPVGYSPMT-PGAPSPGGY-NPHTPG 965


>gi|195546900 suppressor of Ty 5 homolog isoform a [Homo sapiens]
          Length = 1087

 Score = 48.9 bits (115), Expect = 3e-05
 Identities = 34/117 (29%), Positives = 52/117 (44%), Gaps = 13/117 (11%)

Query: 442 GSRSWGRGGTTRRLWDPNNPDQKPALKTQTPQLHFLDTDDEVSPTSWGDSRQAQASYYKF 501
           GSR+  + G     WDPNNP+     + +    +  D +   SP ++G +   Q   Y  
Sbjct: 811 GSRTPAQSGA----WDPNNPNTPS--RAEEEYEYAFDDEPTPSPQAYGGTPNPQTPGYPD 864

Query: 502 QNSD--NPYYYPRTPGPASQYPYTGYNPLQYPVGPTNGVYPGP----YYPGYPTPSG 552
            +S   NP Y P+TPG  + Y    ++P   P  P     P P    Y+   P+P+G
Sbjct: 865 PSSPQVNPQYNPQTPGTPAMYNTDQFSPYAAP-SPQGSYQPSPSPQSYHQVAPSPAG 920



 Score = 37.0 bits (84), Expect = 0.14
 Identities = 35/109 (32%), Positives = 49/109 (44%), Gaps = 22/109 (20%)

Query: 457 DPNNPDQKPALKTQTPQLHFLDTDDEVSPT-------SWGDSRQAQASYYK-------FQ 502
           DP++P   P    QTP    +   D+ SP        S+  S   Q SY++       +Q
Sbjct: 864 DPSSPQVNPQYNPQTPGTPAMYNTDQFSPYAAPSPQGSYQPSPSPQ-SYHQVAPSPAGYQ 922

Query: 503 NSDNPYYYPRTPGP----ASQYPY-TGYNPLQYPVGPTNGVYPGPYYPG 546
           N+ +P  Y  TP P    AS  P   GY+P+  P  P+ G Y  P+ PG
Sbjct: 923 NTHSPASYHPTPSPMAYQASPSPSPVGYSPMT-PGAPSPGGY-NPHTPG 969


>gi|161169023 suppressor of Ty 5 homolog isoform a [Homo sapiens]
          Length = 1087

 Score = 48.9 bits (115), Expect = 3e-05
 Identities = 34/117 (29%), Positives = 52/117 (44%), Gaps = 13/117 (11%)

Query: 442 GSRSWGRGGTTRRLWDPNNPDQKPALKTQTPQLHFLDTDDEVSPTSWGDSRQAQASYYKF 501
           GSR+  + G     WDPNNP+     + +    +  D +   SP ++G +   Q   Y  
Sbjct: 811 GSRTPAQSGA----WDPNNPNTPS--RAEEEYEYAFDDEPTPSPQAYGGTPNPQTPGYPD 864

Query: 502 QNSD--NPYYYPRTPGPASQYPYTGYNPLQYPVGPTNGVYPGP----YYPGYPTPSG 552
            +S   NP Y P+TPG  + Y    ++P   P  P     P P    Y+   P+P+G
Sbjct: 865 PSSPQVNPQYNPQTPGTPAMYNTDQFSPYAAP-SPQGSYQPSPSPQSYHQVAPSPAG 920



 Score = 37.0 bits (84), Expect = 0.14
 Identities = 35/109 (32%), Positives = 49/109 (44%), Gaps = 22/109 (20%)

Query: 457 DPNNPDQKPALKTQTPQLHFLDTDDEVSPT-------SWGDSRQAQASYYK-------FQ 502
           DP++P   P    QTP    +   D+ SP        S+  S   Q SY++       +Q
Sbjct: 864 DPSSPQVNPQYNPQTPGTPAMYNTDQFSPYAAPSPQGSYQPSPSPQ-SYHQVAPSPAGYQ 922

Query: 503 NSDNPYYYPRTPGP----ASQYPY-TGYNPLQYPVGPTNGVYPGPYYPG 546
           N+ +P  Y  TP P    AS  P   GY+P+  P  P+ G Y  P+ PG
Sbjct: 923 NTHSPASYHPTPSPMAYQASPSPSPVGYSPMT-PGAPSPGGY-NPHTPG 969


>gi|20149524 suppressor of Ty 5 homolog isoform a [Homo sapiens]
          Length = 1087

 Score = 48.9 bits (115), Expect = 3e-05
 Identities = 34/117 (29%), Positives = 52/117 (44%), Gaps = 13/117 (11%)

Query: 442 GSRSWGRGGTTRRLWDPNNPDQKPALKTQTPQLHFLDTDDEVSPTSWGDSRQAQASYYKF 501
           GSR+  + G     WDPNNP+     + +    +  D +   SP ++G +   Q   Y  
Sbjct: 811 GSRTPAQSGA----WDPNNPNTPS--RAEEEYEYAFDDEPTPSPQAYGGTPNPQTPGYPD 864

Query: 502 QNSD--NPYYYPRTPGPASQYPYTGYNPLQYPVGPTNGVYPGP----YYPGYPTPSG 552
            +S   NP Y P+TPG  + Y    ++P   P  P     P P    Y+   P+P+G
Sbjct: 865 PSSPQVNPQYNPQTPGTPAMYNTDQFSPYAAP-SPQGSYQPSPSPQSYHQVAPSPAG 920



 Score = 37.0 bits (84), Expect = 0.14
 Identities = 35/109 (32%), Positives = 49/109 (44%), Gaps = 22/109 (20%)

Query: 457 DPNNPDQKPALKTQTPQLHFLDTDDEVSPT-------SWGDSRQAQASYYK-------FQ 502
           DP++P   P    QTP    +   D+ SP        S+  S   Q SY++       +Q
Sbjct: 864 DPSSPQVNPQYNPQTPGTPAMYNTDQFSPYAAPSPQGSYQPSPSPQ-SYHQVAPSPAGYQ 922

Query: 503 NSDNPYYYPRTPGP----ASQYPY-TGYNPLQYPVGPTNGVYPGPYYPG 546
           N+ +P  Y  TP P    AS  P   GY+P+  P  P+ G Y  P+ PG
Sbjct: 923 NTHSPASYHPTPSPMAYQASPSPSPVGYSPMT-PGAPSPGGY-NPHTPG 969


>gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Homo
            sapiens]
          Length = 1152

 Score = 47.8 bits (112), Expect = 8e-05
 Identities = 81/410 (19%), Positives = 150/410 (36%), Gaps = 44/410 (10%)

Query: 30   ENMKELKEARPRKDNRRPDLEIYKPGLSRLRNKPKIKEPPGSEEFKDEIVNDRDCSAVEN 89
            E+ ++ +  +  KD  R ++E    G   L  K + K+  G E+ + E    R+    + 
Sbjct: 667  EHWQDEEREKGEKDKGRGEMERPGEGEKELAEKEEWKKRDGEEQEQKE----REQGHQKE 722

Query: 90   GTQPVKDVCKELNNQ--EQNGPIDPENNRGQESFPRTAGQE---DRSLKIIKRTKKP--- 141
              Q +++  +E + +  E+ G  + E  +  E      G+E   +R  +  +R K+    
Sbjct: 723  RNQEMEEGGEEEHGEGEEEEGDREEEEEKEGEGKEEGEGEEVEGEREKEEGERKKEERAG 782

Query: 142  -DLQIYQPGRRLQTVSKESASRVEEEEVLNQVEQLRV-------EEDECRGNVAKEEVAN 193
             + +  + G + +   +E+  R EE+E   +VE   V       EE+E  G   +EE   
Sbjct: 783  KEEKGEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEG 842

Query: 194  KPDRAEIEKSPGGGR--------VGAAKGEKGKRMG-----------KGEGVRETHDDPA 234
            + +  E E+  G G+         G  +GE+G+  G           +GEG  E  +   
Sbjct: 843  EEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEG 902

Query: 235  RG-RPGSAKRYSRSDKRRNRYRTRSTSSAGSNNSAEGAGLTDNGCRRRRQ---DRTKERP 290
             G   G  +      + +           G     EG G    G     +   +  +E  
Sbjct: 903  EGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEG 962

Query: 291  RLKKQVSVSSTDSLDEDRIDEPDGLGPRRSSERKRHLERNWSGRGEGEQKNSAKEYRGTL 350
              + +          E   +E +G G     E +   E    G  EGE +   +E  G +
Sbjct: 963  EGEGEEEGEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEE-EGEV 1021

Query: 351  RVTFDAEAMNKESPMVRSARDDMDRGKPDKGLSSGGKGSEKQESKNPKQE 400
                + E    E        +  +R K  +G  +     E++E +   QE
Sbjct: 1022 EGEVEGEEGEGEGEEEEGEEEGEEREKEGEGEENRRNREEEEEEEGKYQE 1071



 Score = 42.7 bits (99), Expect = 0.002
 Identities = 52/274 (18%), Positives = 101/274 (36%), Gaps = 20/274 (7%)

Query: 133 KIIKRTKKPDLQIYQPGRRLQTVSKESASRVEEEEVLNQVEQLRVEEDECRGNVAKEEV- 191
           K  K+     + + QP   ++  S E     EE+E     +   +EE E   N    +V 
Sbjct: 557 KACKQHVSQGIFMTQPATTIEAFSDEEVEIPEEKEGAEDSKGNGIEEQEVEANEENVKVH 616

Query: 192 ANKPDRAEIEKSPGGGRVGAAKGEKGKRMGKGEGVRETHDDPARGRPGSAKRYSRSDKRR 251
             + ++ EI       +   ++G K K +G+ E   E   D       S   + + ++R 
Sbjct: 617 GGRKEKTEILSDDLTDKAEVSEG-KAKSVGEAEDGPEGRGDGTCEEGSSGAEHWQDEERE 675

Query: 252 NRYRTRSTSSAGSNNSAEGAGLTDNGCRRRRQDRTKERPRLKKQVSVSSTDSLDEDRIDE 311
              + +           EG          +++D  ++  + ++Q      +   E+  +E
Sbjct: 676 KGEKDKGRGE--MERPGEGEKELAEKEEWKKRDGEEQEQKEREQGHQKERNQEMEEGGEE 733

Query: 312 PDGLGPRRSSERKRHLERNWSGRGEGEQKNSAKEYRGTLRVTFDAEAMNKESPMVRSARD 371
             G G     +R+   E+     GEG+++   +E  G        E   +E    +  R 
Sbjct: 734 EHGEGEEEEGDREEEEEK----EGEGKEEGEGEEVEG--------EREKEEGERKKEER- 780

Query: 372 DMDRGKPDKGLSSGGKGSEKQESKNPKQELRGRG 405
               GK +KG   G +G  ++E    + E +  G
Sbjct: 781 ---AGKEEKGEEEGDQGEGEEEETEGRGEEKEEG 811



 Score = 38.5 bits (88), Expect = 0.046
 Identities = 73/382 (19%), Positives = 134/382 (35%), Gaps = 27/382 (7%)

Query: 30   ENMKELKEARPRKDNRRPDLEIYKPGLSRLRNKPKIKEPPGSEEFKDEIVNDRDCSAVEN 89
            E  +E +E   +K+ R    E  K      + + + +E  G  E K+E   + +   VE 
Sbjct: 765  EGEREKEEGERKKEERAGKEE--KGEEEGDQGEGEEEETEGRGEEKEE-GGEVEGGEVEE 821

Query: 90   GTQPVKDVCKELNNQEQNGPIDPENNRGQESFPRTAGQEDRSLKIIKRTKKPDLQIYQPG 149
            G    ++  +E   +E+ G  + E   G+E      G+E+      +   +      +  
Sbjct: 822  GKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEE 881

Query: 150  RRLQTVSKESASRVEEEEVLNQVEQL---RVEEDECRGNVAKEEVANKPDRAEIEKSPGG 206
                   +E     EEEE   + E+      EE+E  G   +EE        E E+  G 
Sbjct: 882  EGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGK-GEEEGEEGEGEGEEEEGEGE 940

Query: 207  GRVGAAKGEKGK-------RMGKGEGVRETHDDPARGRPGSAKRYSRSDKRRNRYRTRST 259
            G  G  +GE+ +         G+GEG  E   +   G     +     +           
Sbjct: 941  GEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEEEEGEEEGE 1000

Query: 260  SSAGSNNSAEGAGLTDNGCRRRRQDRTKERPRLKKQVSVSSTDSLDEDRIDEPDGLGPRR 319
                     EG G  +       +   +E    + +      +   E+R  E +G   RR
Sbjct: 1001 EEGEGEEEGEGEGEEEEEGEVEGEVEGEEG---EGEGEEEEGEEEGEEREKEGEGEENRR 1057

Query: 320  SSERKRHLERNWSGRGEGE-QKNSAKEYRGTLRVTFDAEAMNKESPMVRSARDDMDRGKP 378
            + E +   E  +   GE E ++   +EY+   ++    +    ++   +S  +    GK 
Sbjct: 1058 NREEEEEEEGKYQETGEEENERQDGEEYKKVSKIKGSVKYGKHKTYQKKSVTNTQGNGKE 1117

Query: 379  DKG---------LSSGGKGSEK 391
             +          L +G  GS+K
Sbjct: 1118 QRSKMPVQSKRLLKNGPSGSKK 1139



 Score = 38.1 bits (87), Expect = 0.061
 Identities = 71/351 (20%), Positives = 124/351 (35%), Gaps = 42/351 (11%)

Query: 61  NKPKIKEPPGSEEFKDEIVNDRDCSAVENGTQPVKDVCKELNNQEQNGP-IDPENNRGQE 119
           N+  +K   G +E K EI++D      E      K V +  +  E  G     E + G E
Sbjct: 609 NEENVKVHGGRKE-KTEILSDDLTDKAEVSEGKAKSVGEAEDGPEGRGDGTCEEGSSGAE 667

Query: 120 SFP---RTAGQEDRSLKIIKRTKKPDLQIYQPGRRLQTVSKESASRVEEEEVLNQVEQLR 176
            +    R  G++D+    ++R  + + ++ +         KE   + + EE     EQ  
Sbjct: 668 HWQDEEREKGEKDKGRGEMERPGEGEKELAE---------KEEWKKRDGEEQ----EQKE 714

Query: 177 VEEDECRGNVAKEEVANKPDRAEIEKSPGGGRVGAAKGEKGKRMGKGEGVRETHDDPARG 236
            E+   +    + E   + +  E E+  G       K  +GK  G+GE V    +     
Sbjct: 715 REQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEEEKEGEGKEEGEGEEVEGEREK---- 770

Query: 237 RPGSAKRYSRSDKRRNRYRTRSTSSAGSNNSAEGAGLTDNGCRRRRQDRTKERPRLKKQV 296
             G  K+  R+ K   +         G     EG G              +E    +++ 
Sbjct: 771 EEGERKKEERAGKEE-KGEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEE 829

Query: 297 SVSSTDSLDEDRIDEPDGLGPRRSSERKRHLERNWSGRGEGEQKNSAKEYRGTLRVTFDA 356
                   +E   +E +G G     E K   E      GEGE++    E  G        
Sbjct: 830 EEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGE---EGEGEEEGEEGEGEG-------- 878

Query: 357 EAMNKESPMVRSARDDMDRGKPDKGLSSGGKGSEKQESKNPKQELRGRGRG 407
               +E        +    G+ ++G    G+G E+ E +  ++E  G G+G
Sbjct: 879 ---EEEEGEGEGEEEGEGEGEEEEG---EGEGEEEGEGEGEEEE--GEGKG 921


>gi|55741709 RNA binding motif protein 25 [Homo sapiens]
          Length = 843

 Score = 47.4 bits (111), Expect = 1e-04
 Identities = 79/379 (20%), Positives = 149/379 (39%), Gaps = 51/379 (13%)

Query: 64  KIKEPPGSEEFKDEIVNDRDCSAVENGT----QPVKDVCKELNNQ---EQNGPIDPENNR 116
           K K+   +   + E V + D  A++  T    Q +K   + L  +   E N P     ++
Sbjct: 173 KAKKKASNGNARPETVTNDDEEALDEETKRRDQMIKGAIEVLIREYSSELNAP-----SQ 227

Query: 117 GQESFPRTAGQEDRSLKIIKRTKKPDLQIYQPGRRLQTVSKESASRVEEEE-----VLNQ 171
             +S PR   +E +   I +R     L  Y        ++KE  + +E EE     +  +
Sbjct: 228 ESDSHPRKKKKEKKE-DIFRRFPVAPLIPYP------LITKEDINAIEMEEDKRDLISRE 280

Query: 172 VEQLR-----VEEDECRGNVAKEEVANKPDRAEIEKSPGGGRVGAAKGEKGKRMGKGEGV 226
           + + R     +EE++ +    ++E+  +    E E+     R    +  + +R  + E  
Sbjct: 281 ISKFRDTHKKLEEEKGKKEKERQEIEKERRERERERERERERREREREREREREREKEKE 340

Query: 227 RETHDDPARGRPGSAKRYSRSDKRRNRYRTRSTSSAGSNNSAEGAGLTDNGCRRRRQDRT 286
           RE   +  R R  + +R    D+ R+R R R  SS  + + +     + +  R R ++R 
Sbjct: 341 RERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERERERERE 400

Query: 287 KERPRLKKQVSVSSTDSLDE-----------DRIDEPDGLGPRRSSERK-RHLE------ 328
           +ER R +++      +   E           DR ++ +    RR  ERK R  E      
Sbjct: 401 REREREREREREREREREREREREREKDKKRDREEDEEDAYERRKLERKLREKEAAYQER 460

Query: 329 -RNWSGRGEGEQKNSAKEYRGTLRVTFDAEAMNKESPMVRSARDDMDRGKPDKGLSSGGK 387
            +NW  R   E+K + +  +   R       M KE+  ++   +D D  + D     G  
Sbjct: 461 LKNWEIR---ERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGSA 517

Query: 388 GSEKQESKNPKQELRGRGR 406
             ++   +  + E   R R
Sbjct: 518 LQKRLRDREKEMEADERDR 536



 Score = 30.8 bits (68), Expect = 9.7
 Identities = 43/198 (21%), Positives = 83/198 (41%), Gaps = 11/198 (5%)

Query: 29  RENMKELKEARPRKDNRRPDLEIYKPGL-SRLRNKPKIKEPPGSEEFKDE--IVNDRDCS 85
           +E ++E+++    + +  PD E+ +    +  R +P+IK+ P SEE ++E     ++   
Sbjct: 540 KEELEEIRQRLLAEGHPDPDAELQRMEQEAERRRQPQIKQEPESEEEEEEKQEKEEKREE 599

Query: 86  AVENGTQPVKDVCKELNNQEQNGPIDPENNRGQESFPRTAGQEDRSLKIIKRTKKPDLQI 145
            +E   +P +  C +   +  +      +  G  + P T G E     II     PD Q 
Sbjct: 600 PMEEEEEPEQKPCLKPTLRPISSAPSVSSASGNAT-PNTPGDESPCGIIIPHENSPDQQQ 658

Query: 146 YQPGR-RLQTVSKESASRVEEEEVLNQVEQLRVE------EDECRGNVAKEEVANKPDRA 198
            +  R ++    K  AS    +    + ++L V+      EDE   +V ++      D  
Sbjct: 659 PEEHRPKIGLSLKLGASNSPGQPNSVKRKKLPVDSVFNKFEDEDSDDVPRKRKLVPLDYG 718

Query: 199 EIEKSPGGGRVGAAKGEK 216
           E +K+   G V   +  K
Sbjct: 719 EDDKNATKGTVNTEEKRK 736


>gi|21361282 splicing factor, arginine/serine-rich 4 [Homo sapiens]
          Length = 494

 Score = 47.0 bits (110), Expect = 1e-04
 Identities = 49/209 (23%), Positives = 86/209 (41%), Gaps = 31/209 (14%)

Query: 223 GEGVRETHDDPARGRPGSAKRY-----SRSDKRRNRY-RTRSTSSAGSNNSAEGAGLTDN 276
           G  +R   D P   R  S  R      SRS  R +R  R+RS SS  S++ +     + +
Sbjct: 167 GRKIRLVEDKPGSRRRRSYSRSRSHSRSRSRSRHSRKSRSRSGSSKSSHSKSRSRSRSGS 226

Query: 277 GCRRRRQDRTKERPRLKKQVSVSSTDSLD------------------EDRIDEPDGLGPR 318
             R + + R++ R R KK+ S S +                      E++I   D +G  
Sbjct: 227 RSRSKSRSRSQSRSRSKKEKSRSPSKEKSRSRSHSAGKSRSKSKDQAEEKIQNNDNVGKP 286

Query: 319 RSSERKRHLERNWSGRGEGEQKNSAKEYRGTLRVTFDAEAMNKESPMVRSARDDMDRGKP 378
           +S    RH  ++ S R   +++   +E RG++     +   ++E  + +S      +G  
Sbjct: 287 KSRSPSRHKSKSKS-RSRSQERRVEEEKRGSV-----SRGRSQEKSLRQSRSRSRSKGGS 340

Query: 379 DKGLSSGGKGSEKQES-KNPKQELRGRGR 406
                S  K  +K++  K  ++E R R R
Sbjct: 341 RSRSRSRSKSKDKRKGRKRSREESRSRSR 369



 Score = 38.1 bits (87), Expect = 0.061
 Identities = 47/222 (21%), Positives = 81/222 (36%), Gaps = 20/222 (9%)

Query: 187 AKEEVANKPDRAEIEKSPGGGRVGAAKGEKGKRMGKGEGVRETHDDPARGRPGSAKRYSR 246
           +K+E +  P +   EKS    R  +A   + K   + E   + +D+  + +  S  R+  
Sbjct: 242 SKKEKSRSPSK---EKSRS--RSHSAGKSRSKSKDQAEEKIQNNDNVGKPKSRSPSRHKS 296

Query: 247 SDKRRNRYRTRSTSSAGSNNSAEGAGLTDNGCRRRRQDRTKERPRLKKQVSVSSTDSLDE 306
             K R+R + R        + + G     +  + R + R+K   R + +    S D    
Sbjct: 297 KSKSRSRSQERRVEEEKRGSVSRGRSQEKSLRQSRSRSRSKGGSRSRSRSRSKSKDKRKG 356

Query: 307 DRIDEPDGLGPRRSSERKRHLERNWSGRGE--GEQKNSAKEYRGTLRVTFDAEAMNKESP 364
            +    +     RS  +     +  S R    G  K   KE         D +     SP
Sbjct: 357 RKRSREESRSRSRSRSKSERSRKRGSKRDSKAGSSKKKKKE---------DTDRSQSRSP 407

Query: 365 MVRSARDDMDRGKPDKGLSSGGKGSEKQESKNPKQELRGRGR 406
             RS   + +  K +   SS  +G  + E+    QE R R R
Sbjct: 408 S-RSVSKEREHAKSE---SSQREGRGESENAGTNQETRSRSR 445



 Score = 37.7 bits (86), Expect = 0.079
 Identities = 50/275 (18%), Positives = 101/275 (36%), Gaps = 16/275 (5%)

Query: 25  QAGSRENMKELKEARPRKDNRRPDLEIYKPGLSRLRNKPKIKEPPGSEEFKDEIVNDRDC 84
           ++GSR   K    ++ R  +++          SR R+    K    S++  +E + + D 
Sbjct: 223 RSGSRSRSKSRSRSQSRSRSKKEKSRSPSKEKSRSRSHSAGKSRSKSKDQAEEKIQNNDN 282

Query: 85  SAVENGTQPVKDVCKELNNQEQNGPIDPENNRGQESFPRTAGQEDRSLKIIKRTK----- 139
                   P +   K  +          E  RG  S  R+  +  R  +   R+K     
Sbjct: 283 VGKPKSRSPSRHKSKSKSRSRSQERRVEEEKRGSVSRGRSQEKSLRQSRSRSRSKGGSRS 342

Query: 140 ----KPDLQIYQPGRRLQTVSKESASRVEEEEVLNQVEQLRVEEDECRGNVAKEEVANKP 195
               +   +  + GR+       S SR   +   ++  + R  + + +   +K++     
Sbjct: 343 RSRSRSKSKDKRKGRKRSREESRSRSRSRSK---SERSRKRGSKRDSKAGSSKKKKKEDT 399

Query: 196 DRAEIEKSPG---GGRVGAAKGEKGKRMGKGEGVRETHDDPARGRPGSAKRYSRSDKRRN 252
           DR++  +SP          AK E  +R G+GE      +   R R  S  +   +    +
Sbjct: 400 DRSQ-SRSPSRSVSKEREHAKSESSQREGRGESENAGTNQETRSRSRSNSKSKPNLPSES 458

Query: 253 RYRTRSTSSAGSNNSAEGAGLTDNGCRRRRQDRTK 287
           R R++S S   S + +     + +  R R +  ++
Sbjct: 459 RSRSKSASKTRSRSKSRSRSASRSPSRSRSRSHSR 493


>gi|207113199 erythrocyte membrane protein band 4.1-like 2 isoform b
           [Homo sapiens]
          Length = 673

 Score = 46.6 bits (109), Expect = 2e-04
 Identities = 49/184 (26%), Positives = 78/184 (42%), Gaps = 34/184 (18%)

Query: 90  GTQPVKDVCKELNNQEQNGPIDPENNRGQESFPRTAGQEDRSLKIIKRTKKPD-----LQ 144
           GT   K+  KE+   +QN   DPE  +G +  P  A +   SL+  KR K+        +
Sbjct: 19  GTDATKEKPKEVAENQQNQSSDPEEEKGSQ--PPPAAESQSSLRRQKREKETSESRGISR 76

Query: 145 IYQPGRRLQTV-----------SKESASRVEEEEVLNQVEQLRVEEDECRGNVAKEEVAN 193
              P  + Q              KE    V EE+VL++ E L  E+ + +G+   EE+A 
Sbjct: 77  FIPPWLKKQKSYTLVVAKDGGDKKEPTQAVVEEQVLDKEEPLPEEQRQAKGDA--EEMAQ 134

Query: 194 KPDRAEI-----------EKSPGGGRVGAAKGEKGKRMGKGEGVRETHDDPARGRPGSAK 242
           K    ++           E+ P   +V     E   +  + E V+ET +D   G  G+AK
Sbjct: 135 KKQEIKVEVKEEKPSVSKEEKPSVSKVEMQPTELVSK-EREEKVKETQEDKLEG--GAAK 191

Query: 243 RYSR 246
           R ++
Sbjct: 192 RETK 195


>gi|207113195 erythrocyte membrane protein band 4.1-like 2 isoform b
           [Homo sapiens]
          Length = 673

 Score = 46.6 bits (109), Expect = 2e-04
 Identities = 49/184 (26%), Positives = 78/184 (42%), Gaps = 34/184 (18%)

Query: 90  GTQPVKDVCKELNNQEQNGPIDPENNRGQESFPRTAGQEDRSLKIIKRTKKPD-----LQ 144
           GT   K+  KE+   +QN   DPE  +G +  P  A +   SL+  KR K+        +
Sbjct: 19  GTDATKEKPKEVAENQQNQSSDPEEEKGSQ--PPPAAESQSSLRRQKREKETSESRGISR 76

Query: 145 IYQPGRRLQTV-----------SKESASRVEEEEVLNQVEQLRVEEDECRGNVAKEEVAN 193
              P  + Q              KE    V EE+VL++ E L  E+ + +G+   EE+A 
Sbjct: 77  FIPPWLKKQKSYTLVVAKDGGDKKEPTQAVVEEQVLDKEEPLPEEQRQAKGDA--EEMAQ 134

Query: 194 KPDRAEI-----------EKSPGGGRVGAAKGEKGKRMGKGEGVRETHDDPARGRPGSAK 242
           K    ++           E+ P   +V     E   +  + E V+ET +D   G  G+AK
Sbjct: 135 KKQEIKVEVKEEKPSVSKEEKPSVSKVEMQPTELVSK-EREEKVKETQEDKLEG--GAAK 191

Query: 243 RYSR 246
           R ++
Sbjct: 192 RETK 195


>gi|4503579 erythrocyte membrane protein band 4.1-like 2 isoform a
           [Homo sapiens]
          Length = 1005

 Score = 46.6 bits (109), Expect = 2e-04
 Identities = 49/184 (26%), Positives = 78/184 (42%), Gaps = 34/184 (18%)

Query: 90  GTQPVKDVCKELNNQEQNGPIDPENNRGQESFPRTAGQEDRSLKIIKRTKKPD-----LQ 144
           GT   K+  KE+   +QN   DPE  +G +  P  A +   SL+  KR K+        +
Sbjct: 19  GTDATKEKPKEVAENQQNQSSDPEEEKGSQ--PPPAAESQSSLRRQKREKETSESRGISR 76

Query: 145 IYQPGRRLQTV-----------SKESASRVEEEEVLNQVEQLRVEEDECRGNVAKEEVAN 193
              P  + Q              KE    V EE+VL++ E L  E+ + +G+   EE+A 
Sbjct: 77  FIPPWLKKQKSYTLVVAKDGGDKKEPTQAVVEEQVLDKEEPLPEEQRQAKGDA--EEMAQ 134

Query: 194 KPDRAEI-----------EKSPGGGRVGAAKGEKGKRMGKGEGVRETHDDPARGRPGSAK 242
           K    ++           E+ P   +V     E   +  + E V+ET +D   G  G+AK
Sbjct: 135 KKQEIKVEVKEEKPSVSKEEKPSVSKVEMQPTELVSK-EREEKVKETQEDKLEG--GAAK 191

Query: 243 RYSR 246
           R ++
Sbjct: 192 RETK 195


>gi|239754909 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 245

 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 61/232 (26%), Positives = 87/232 (37%), Gaps = 38/232 (16%)

Query: 176 RVEEDECRGNVAKE-EVANKPDRAEIEKSPGGGRVGAAKGEKGKRMGKGEGVRETHDDPA 234
           R  E E R    KE E   K +R E EK     R    K E+GK+  KGE  +E  +   
Sbjct: 41  REREIETRKEGKKERESERKKERREREKRKRE-REKERKRERGKKEKKGERKKEERERKK 99

Query: 235 RGRPGSAKRYSRSDKRRNRYRTR--STSSAGSNNSAEGAGLTDNGCRRRRQDRTKERPRL 292
           R R    K     +KR+ + +     TS  G     +           R+++  KER R 
Sbjct: 100 RRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERK---------EERKREERKERERK 150

Query: 293 KKQVSVSSTDSLDEDRIDEPDGLGPRRSSERKRHLERNWSGRGEGEQKNSAKEYRGTLRV 352
           K            E+R  E      R   ERK+  ER   G  E E+K   ++ R     
Sbjct: 151 K------------EEREKE------RERKERKKR-ERKQVGEKEEERKEKERKERK---- 187

Query: 353 TFDAEAMNKESPMVRSARDDMDRGKPDKGLSSGGKGSEKQESKNPKQELRGR 404
               E   KE    R  ++  +R K  K      K  +K    N +++ RG+
Sbjct: 188 --KRERNRKERKKERERKERRERKKERKKKEERKKERQKDRQTNWREKERGK 237



 Score = 31.2 bits (69), Expect = 7.4
 Identities = 46/216 (21%), Positives = 82/216 (37%), Gaps = 27/216 (12%)

Query: 45  RRPDLEIYKPGLSRLRNKPKIKEPPGSEEFKDEIVNDRDCSAVENGTQPVKDVCKELNNQ 104
           R  ++E  K G  + R   + KE    E+ K E   +R     E G +  K   K+   +
Sbjct: 41  REREIETRKEG-KKERESERKKERREREKRKREREKERKR---ERGKKEKKGERKKEERE 96

Query: 105 EQNGPIDPENNRGQESFPRTAGQEDRSLKIIKRTKKPDLQIYQPGRRLQTVSKESASRVE 164
            +    + EN  G+E   R            K+ KK      + GR     SKE   R  
Sbjct: 97  RKKRRREKENKEGEEKEKRK-----------KKEKK------ERGR----TSKEGKERER 135

Query: 165 EEEVLNQVEQLRVEEDECRGNVAKEEVANKPDRAEIEKSPGGGRVGAAKGEKGKRMGKGE 224
           +EE   +  + R  + E R    + +   K +R ++ +     +    K  K +   + E
Sbjct: 136 KEERKREERKERERKKEEREKERERKERKKRERKQVGEKEEERKEKERKERKKRERNRKE 195

Query: 225 GVRETHDDPARGRPGSAKRYSRSDKRRNRYRTRSTS 260
             +E      R R    +R  + ++++ R + R T+
Sbjct: 196 RKKERERKERRER--KKERKKKEERKKERQKDRQTN 229


>gi|116089325 splicing factor, arginine/serine-rich 12 isoform a
           [Homo sapiens]
          Length = 624

 Score = 45.1 bits (105), Expect = 5e-04
 Identities = 52/243 (21%), Positives = 100/243 (41%), Gaps = 16/243 (6%)

Query: 136 KRTKKPDLQIYQPGRRLQTVSKESASRVEEEEVLNQVEQLRVEEDECRGNVAKEEVANKP 195
           KR+K  + +  +     +   K++  +++E+E + + ++ +  E E      KE   NK 
Sbjct: 357 KRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKD 416

Query: 196 DRAEIEKSPGGGRVGAAKGEKGKRMGKGEGVRETHDDPARGRPGSAKRYSRSDKRRNRYR 255
              E EK     +    + E+ K   K    +E   +  + +     R    D++R + +
Sbjct: 417 RDKEREKDREKDKEKDREREREKEHEKDRD-KEKEKEQDKEKEREKDRSKEIDEKRKKDK 475

Query: 256 TRSTSSAGSNNSAEGAGLTDNGCRRRRQDRTKERPRLKKQV--------SVSSTDSLDED 307
            +S +   S N++  +  +    RRRR   +   PR  K +        S  S +  D+ 
Sbjct: 476 -KSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKK 534

Query: 308 RIDEPDGLGPRRSSERKRHLERNWSGRGEGE--QKNSA----KEYRGTLRVTFDAEAMNK 361
           R  E D +  RR  ER   + ++ + R   E  +KNS     KE+      +   E  +K
Sbjct: 535 REKERDHISERRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDK 594

Query: 362 ESP 364
           ++P
Sbjct: 595 DAP 597



 Score = 39.3 bits (90), Expect = 0.027
 Identities = 44/187 (23%), Positives = 77/187 (41%), Gaps = 15/187 (8%)

Query: 211 AAKGEKGKRMGKGEGVRETHDDPARGRPGSAKRYSRSDKRRNRYRTRSTSSAGSNNSAEG 270
           A + E GK   +  G   +H   ++ R  S+K +SR  + ++++R+RS + + S      
Sbjct: 292 AIEPESGKSNERKGGRSRSHTR-SKSR-SSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRR 349

Query: 271 AGLTDNGCRRRRQDRTKERPRLKKQVSVSSTDS--LDEDRIDEPDGLGPRRSSERKRHLE 328
              + +  R + ++R K R R   +     T     +++R+ E D     R  ER+R  E
Sbjct: 350 RSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKD-----REKEREREKE 404

Query: 329 RNWSGRGEGEQKNSAKEYRGTLRVTFDAEAMNKESPMVRSARDDMDRGKPDKGLSSGGKG 388
           R      E E++    + R   R     +   K+    R    + DR K  +      K 
Sbjct: 405 R------EKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKE 458

Query: 389 SEKQESK 395
            EK  SK
Sbjct: 459 REKDRSK 465


>gi|21040255 splicing factor, arginine/serine-rich 12 isoform b
           [Homo sapiens]
          Length = 508

 Score = 45.1 bits (105), Expect = 5e-04
 Identities = 52/243 (21%), Positives = 100/243 (41%), Gaps = 16/243 (6%)

Query: 136 KRTKKPDLQIYQPGRRLQTVSKESASRVEEEEVLNQVEQLRVEEDECRGNVAKEEVANKP 195
           KR+K  + +  +     +   K++  +++E+E + + ++ +  E E      KE   NK 
Sbjct: 241 KRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKD 300

Query: 196 DRAEIEKSPGGGRVGAAKGEKGKRMGKGEGVRETHDDPARGRPGSAKRYSRSDKRRNRYR 255
              E EK     +    + E+ K   K    +E   +  + +     R    D++R + +
Sbjct: 301 RDKEREKDREKDKEKDREREREKEHEKDRD-KEKEKEQDKEKEREKDRSKEIDEKRKKDK 359

Query: 256 TRSTSSAGSNNSAEGAGLTDNGCRRRRQDRTKERPRLKKQV--------SVSSTDSLDED 307
            +S +   S N++  +  +    RRRR   +   PR  K +        S  S +  D+ 
Sbjct: 360 -KSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKK 418

Query: 308 RIDEPDGLGPRRSSERKRHLERNWSGRGEGE--QKNSA----KEYRGTLRVTFDAEAMNK 361
           R  E D +  RR  ER   + ++ + R   E  +KNS     KE+      +   E  +K
Sbjct: 419 REKERDHISERRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDK 478

Query: 362 ESP 364
           ++P
Sbjct: 479 DAP 481



 Score = 39.3 bits (90), Expect = 0.027
 Identities = 44/187 (23%), Positives = 77/187 (41%), Gaps = 15/187 (8%)

Query: 211 AAKGEKGKRMGKGEGVRETHDDPARGRPGSAKRYSRSDKRRNRYRTRSTSSAGSNNSAEG 270
           A + E GK   +  G   +H   ++ R  S+K +SR  + ++++R+RS + + S      
Sbjct: 176 AIEPESGKSNERKGGRSRSHTR-SKSR-SSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRR 233

Query: 271 AGLTDNGCRRRRQDRTKERPRLKKQVSVSSTDS--LDEDRIDEPDGLGPRRSSERKRHLE 328
              + +  R + ++R K R R   +     T     +++R+ E D     R  ER+R  E
Sbjct: 234 RSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKD-----REKEREREKE 288

Query: 329 RNWSGRGEGEQKNSAKEYRGTLRVTFDAEAMNKESPMVRSARDDMDRGKPDKGLSSGGKG 388
           R      E E++    + R   R     +   K+    R    + DR K  +      K 
Sbjct: 289 R------EKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKE 342

Query: 389 SEKQESK 395
            EK  SK
Sbjct: 343 REKDRSK 349


>gi|188536004 zinc finger protein 469 [Homo sapiens]
          Length = 3925

 Score = 44.7 bits (104), Expect = 6e-04
 Identities = 92/374 (24%), Positives = 129/374 (34%), Gaps = 76/374 (20%)

Query: 233  PARGRPG--------------SAKRYSRSDKRRNRYRTRSTSSAGSNNSAEGAGLTDNGC 278
            PARGRP               S  R  R  K+   +R    S   +  S  G G   +G 
Sbjct: 919  PARGRPKTRSLGLAPTEADAPSQGRQQRRGKQLKLFRKDLDSGGAAEGSGSGGGGRASGL 978

Query: 279  RRRRQDRTKERP-----RLKKQVSVSSTDSLDEDRIDEPDGLGPRRSSERKRHLE----- 328
            R RR D   ERP     R + Q   S  D     R+     L     S R+R L      
Sbjct: 979  RPRRNDGLGERPPPRPRRPRTQAPGSRADPAP--RVPRAAALPEETRSSRRRRLPPRKDP 1036

Query: 329  RNWSGRGEG----------EQKNSAKEYRGTLRVTFDAEAMNKESPMVRSARDDMDRGKP 378
            R    RG            +QKN  +EY       F +E+   E P  R       RG+ 
Sbjct: 1037 RKRKARGGAWGKELILKIVQQKNRLREY------DFASESEEDEQPPPRGPGFRGRRGRG 1090

Query: 379  DKG----LSSGGKGSEKQES-KNPKQELRGRGRGILILPAHTTLSVNSAGSPESAPL--G 431
            +K     L+ G +  E Q+  K  +QE  G G      PA+      S   P  +P   G
Sbjct: 1091 EKRKEVELTQGPREDEPQKPRKAARQEAGGDGA-----PANPEEPGGSRPGPGRSPQARG 1145

Query: 432  PRLLFGSGSKGSRSWGRGGTTRRLWDPNNPDQKPALKTQTPQLHFLDTDDEVSPTSWGDS 491
            P     +G+  +R  G     R    P +P Q P   T T      +T +E  P      
Sbjct: 1146 PSRSLETGA-AAREGGPKCADRPSVAPKDPLQVP---TNT------ETSEETRP------ 1189

Query: 492  RQAQASYYKFQNSDNPYYYPRTPGPASQYPYTGYNPLQYPVGPTNGVYPGPYYPGYPTPS 551
                 S    Q +  P     +   ++++     +P     G   G  PG   P  P PS
Sbjct: 1190 -----SLDFPQEAKEPETAEESAPDSTEFTEALRSPPAACAGEM-GASPGLLIPEQPPPS 1243

Query: 552  GQYVCSPLPTSTMS 565
                 +P P+ +++
Sbjct: 1244 RHDTGTPKPSGSLA 1257



 Score = 34.3 bits (77), Expect = 0.88
 Identities = 27/100 (27%), Positives = 40/100 (40%), Gaps = 9/100 (9%)

Query: 377  KPDKGLSSGGKGSEKQESKNPKQELRGRGRGILILP----AHTTLSVNSAGSPESAPLGP 432
            +P+ G+S GG  +    + +PK  L G   G ++L     +   +S+     P  +P  P
Sbjct: 1974 QPENGVSPGGTDNHASVNASPKTALTGPTEGAVLLEKCKGSRAAMSLQEEAEPTPSPPSP 2033

Query: 433  R---LLFGSGSKGSRSWGRGGTTRRLWDPNNPDQKPALKT 469
                L     +  SRS   G T  R   P     KP L T
Sbjct: 2034 NRESLALALTAAHSRSGSEGRTPERASSPGL--NKPLLAT 2071


>gi|15149465 caldesmon 1 isoform 5 [Homo sapiens]
          Length = 532

 Score = 44.7 bits (104), Expect = 6e-04
 Identities = 89/403 (22%), Positives = 157/403 (38%), Gaps = 62/403 (15%)

Query: 11  SASELRGILATLAPQAGSRENMKELKEARPRKDNRRPDLEIYKPGLSRLRNKPKIKEPPG 70
           S S  R  LA L+  A  R +  E + AR R+   R +         RLR K +      
Sbjct: 5   SGSHGRRSLAALSQIAYQRNDDDEEEAARERRRRARQE---------RLRQKQE------ 49

Query: 71  SEEFKDEIVNDRDCSAVENGTQPVKDVCKELNNQEQNGPIDPENNRGQESFPRTAGQEDR 130
            EE   ++ +  + +A    + P ++      N +  G  D E    +    R   ++ R
Sbjct: 50  -EESLGQVTDQVEVNA--QNSVPDEEAKTTTTNTQVEG--DDEAAFLERLARREERRQKR 104

Query: 131 SLKIIKRTKK-----PDLQIYQPGRRLQTVSKESASRVEEEEVLNQVEQLRVEEDEC--- 182
             + ++R K+      D  +  P RR+Q  + E+ +  +EE+  ++ E+  +EE E    
Sbjct: 105 LQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTK 164

Query: 183 --RGNVAKEEVANKPD----RAEIEKSPGGGRVG--AAKGEKGKRMGKGEGVRETHDDPA 234
             + N  ++   NK +      E E+ P  G +G    K EK K+  + +   ++  D  
Sbjct: 165 SYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQIKDEKIKKDKEPKEEVKSFMDRK 224

Query: 235 RGRPGSAKRYSRSDKRRNRYRTRSTSSAGSNNS-----AEGAGLTDNG-----CRRRRQD 284
           +G      +       + ++   + S  G   S     AEGA   + G      RRRR +
Sbjct: 225 KGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGE 284

Query: 285 RTKERPRLKKQVSVSSTDSLDEDRIDEPDGLGPRRSSERKRHLERNWSGRGEGEQKNSAK 344
              E     KQ    +   L+E +         ++  ER++ LE       E EQ+   +
Sbjct: 285 TESEEFEKLKQKQQEAALELEELK---------KKREERRKVLE-------EEEQRRKQE 328

Query: 345 EYRGTLRVTFDAEAMNKESPMVRSARDDMDRGKPDKGLSSGGK 387
           E    LR   +   + +E    R+   +  +  P+ GLS   K
Sbjct: 329 EADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKK 371


>gi|41055989 M-phase phosphoprotein 8 [Homo sapiens]
          Length = 860

 Score = 44.3 bits (103), Expect = 8e-04
 Identities = 82/382 (21%), Positives = 143/382 (37%), Gaps = 50/382 (13%)

Query: 33  KELKEARPRKDNRRPDLEIYKPGLSRLRNKPKIKEPPGSEEFKDEIVND-RDCSAVENGT 91
           K+ K+ R R++    DL+  K    +L++K K    P  E   + +V D R    +    
Sbjct: 152 KKKKKLRQREEKSPDDLKKKKAKAGKLKDKSK----PDLESSLESLVFDLRTKKRISEAK 207

Query: 92  QPVKDVCKELNNQEQNGPIDPENNRGQESFPRTAGQEDRSLKIIKRTKKPDLQIYQPGRR 151
           + +K+  K   ++ +      +  +G+    +T  +ED   K  ++TKK           
Sbjct: 208 EELKESKKPKKDEVKETKELKKVKKGEIRDLKTKTREDP--KENRKTKK----------- 254

Query: 152 LQTVSKESASRVEEEEVLNQVEQLRVEEDECRGNVAKEEVANKPDRAEIEKSPGGGRVGA 211
                K   S+VE E  +        ++ E   + ++EE  N     E        R G 
Sbjct: 255 ----EKFVESQVESESSVLNDSPFPEDDSEGLHSDSREEKQNTKSARE--------RAGQ 302

Query: 212 AKG-EKGKRMGKGEGVRETHDDPARGRPGSAKRYSRSDKRRNRYRTRSTSSAGSNNSAEG 270
             G E G        +    D   RGR          D R NR      +        + 
Sbjct: 303 DMGLEHGFEKPLDSAMSAEEDTDVRGRRKKKTPRKAEDTRENRKLENKNAFLEKKTVPK- 361

Query: 271 AGLTDNGCRRRRQDRTKERPRLKKQVSVSSTDSLDEDRIDEPDGLGPRRSSERKRHLERN 330
                   ++R QDR+K    L+K + VS+          E  GL    S+E  +  +RN
Sbjct: 362 --------KQRNQDRSKSAAELEKLMPVSAQTPKGRRLSGEERGLWSTDSAEEDKETKRN 413

Query: 331 WSGRGEGEQKNSAKEYRG--------TLRVTFDAEAMNKESPMVRSARDDMDRGKPDKGL 382
            S     ++ +S KE +G        TL+   +A  + K +P  ++   + +R + +  L
Sbjct: 414 ESKEKYQKRHDSDKEEKGRKEPKGLKTLKEIRNAFDLFKLTPEEKNDVSENNRKREEIPL 473

Query: 383 SSGGKGSEKQESKNPKQELRGR 404
               K  +  ++K  KQ L+ R
Sbjct: 474 DF--KTIDDHKTKENKQSLKER 493


>gi|22035679 AT rich interactive domain 4B isoform 2 [Homo sapiens]
          Length = 1226

 Score = 44.3 bits (103), Expect = 8e-04
 Identities = 57/296 (19%), Positives = 112/296 (37%), Gaps = 44/296 (14%)

Query: 32  MKELKEARPRKDNRRPDLEIYKPGLSRLR--NKPKIKEPPGSEEFKDEIVNDR------- 82
           +K  K+ + + D  +   E Y P   +LR  +KP  +  P  E      + D        
Sbjct: 549 IKHRKKIKNKLDKEKDKDEKYSPKNCKLRRLSKPPFQTNPSPEMVSKLDLTDAKNSDTAH 608

Query: 83  ----DCSAVENGTQPVKDVCKELNNQEQNGPIDPENNRGQESF---------PRTAGQED 129
               + +++ NG Q  +   ++   +++ G  D +NN  +ES             + +E 
Sbjct: 609 IKSIEITSILNGLQASESSAEDSEQEDERGAQDMDNNGKEESKIDHLTNNRNDLISKEEQ 668

Query: 130 RSLKIIKRTK-KPDLQIYQPGRRLQTVSKESASRVEEEEVLNQVEQLRVEEDECRGNVAK 188
            S  +++  K   DL I +P      VSK      ++ EVL++      +E   +    K
Sbjct: 669 NSSSLLEENKVHADLVISKP------VSKSPERLRKDIEVLSEDTDYEEDEVTKKRKDVK 722

Query: 189 EEVANKPDRAEIEK---------------SPGGGRVGAAKGEKGKRMGKGEGVRETHDDP 233
           ++  +K  + +I++               SPG     A   E            +  ++ 
Sbjct: 723 KDTTDKSSKPQIKRGKRRYCNTEECLKTGSPGKKEEKAKNKESLCMENSSNSSSDEDEEE 782

Query: 234 ARGRPGSAKRYSRSDKRRNRYRTRSTSSAGSNNSAEGAGLTDNGCRRRRQDRTKER 289
            + +    K+Y+  +++R   RT    S  S  + +   L +N   R +  R K+R
Sbjct: 783 TKAKMTPTKKYNGLEEKRKSLRTTGFYSGFSEVAEKRIKLLNNSDERLQNSRAKDR 838


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.314    0.132    0.383 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 58,586,124
Number of Sequences: 37866
Number of extensions: 3046359
Number of successful extensions: 13296
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 65
Number of HSP's successfully gapped in prelim test: 363
Number of HSP's that attempted gapping in prelim test: 11622
Number of HSP's gapped (non-prelim): 1709
length of query: 1419
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1304
effective length of database: 13,892,928
effective search space: 18116378112
effective search space used: 18116378112
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.