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Search of human proteins with 115430110
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|115430110 hypothetical protein LOC153643 [Homo sapiens]
(452 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|115430110 hypothetical protein LOC153643 [Homo sapiens] 880 0.0
gi|148613880 hypothetical protein LOC145773 [Homo sapiens] 215 6e-56
gi|31982906 cingulin-like 1 [Homo sapiens] 65 2e-10
gi|83715968 sarcoma antigen NY-SAR-79 [Homo sapiens] 62 1e-09
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 61 2e-09
gi|114155142 nuclear pore complex-associated protein TPR [Homo s... 60 5e-09
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 57 4e-08
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 57 4e-08
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 56 6e-08
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 56 6e-08
gi|71061468 centromere protein E [Homo sapiens] 56 6e-08
gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens] 54 3e-07
gi|237858621 polyamine modulated factor 1 binding protein 1 isof... 54 4e-07
gi|237858619 polyamine modulated factor 1 binding protein 1 isof... 54 4e-07
gi|214010216 SMC6 protein [Homo sapiens] 54 4e-07
gi|13375848 SMC6 protein [Homo sapiens] 54 4e-07
gi|58530840 desmoplakin isoform I [Homo sapiens] 53 5e-07
gi|33188443 microfilament and actin filament cross-linker protei... 53 5e-07
gi|33188445 microfilament and actin filament cross-linker protei... 53 5e-07
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H... 53 6e-07
gi|51472437 PREDICTED: golgi autoantigen, golgin subfamily a, 6C... 52 8e-07
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 52 8e-07
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 52 8e-07
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 52 8e-07
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 52 8e-07
gi|239745127 PREDICTED: similar to Putative golgin subfamily A m... 52 1e-06
gi|223634475 golgi autoantigen, golgin subfamily a, 6D [Homo sap... 52 1e-06
gi|239745153 PREDICTED: similar to Putative golgin subfamily A m... 52 1e-06
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li... 52 1e-06
gi|109659847 filamin A interacting protein 1-like isoform 3 [Hom... 52 1e-06
>gi|115430110 hypothetical protein LOC153643 [Homo sapiens]
Length = 452
Score = 880 bits (2274), Expect = 0.0
Identities = 452/452 (100%), Positives = 452/452 (100%)
Query: 1 MQLQFLGTLASSEKRKKSQRLFFKNIKSTKNKAGKASIMSSDTNVNKSASPTATAEEQPV 60
MQLQFLGTLASSEKRKKSQRLFFKNIKSTKNKAGKASIMSSDTNVNKSASPTATAEEQPV
Sbjct: 1 MQLQFLGTLASSEKRKKSQRLFFKNIKSTKNKAGKASIMSSDTNVNKSASPTATAEEQPV 60
Query: 61 EPDGPLPGSDNNQEKKVRLSPAKMSTKNSTDLVEYVDKSHAFLPIIPNTQRGQLEDRLNN 120
EPDGPLPGSDNNQEKKVRLSPAKMSTKNSTDLVEYVDKSHAFLPIIPNTQRGQLEDRLNN
Sbjct: 61 EPDGPLPGSDNNQEKKVRLSPAKMSTKNSTDLVEYVDKSHAFLPIIPNTQRGQLEDRLNN 120
Query: 121 QARTIAFLLEQAFRIKEDISACLQGTHGFRKEESLARKLLESHIQTITSIVKKLSQNIEI 180
QARTIAFLLEQAFRIKEDISACLQGTHGFRKEESLARKLLESHIQTITSIVKKLSQNIEI
Sbjct: 121 QARTIAFLLEQAFRIKEDISACLQGTHGFRKEESLARKLLESHIQTITSIVKKLSQNIEI 180
Query: 181 LEDQIRARDQAATGTNFAVHEINIKHLQGVGDLRGRVARCDSSIVKLSGDIHLFRQEHRQ 240
LEDQIRARDQAATGTNFAVHEINIKHLQGVGDLRGRVARCDSSIVKLSGDIHLFRQEHRQ
Sbjct: 181 LEDQIRARDQAATGTNFAVHEINIKHLQGVGDLRGRVARCDSSIVKLSGDIHLFRQEHRQ 240
Query: 241 IEKAIQEFVPALETLSKNLDMKVMQLLGKIETASSEQTSNLKMVQGDYRHEMNLLEFKFH 300
IEKAIQEFVPALETLSKNLDMKVMQLLGKIETASSEQTSNLKMVQGDYRHEMNLLEFKFH
Sbjct: 241 IEKAIQEFVPALETLSKNLDMKVMQLLGKIETASSEQTSNLKMVQGDYRHEMNLLEFKFH 300
Query: 301 SLSSNLYEEVENNKKWTENQFLKYRKDHLGHINECLKVLQEKLEKSENKMEEKLLQLSSK 360
SLSSNLYEEVENNKKWTENQFLKYRKDHLGHINECLKVLQEKLEKSENKMEEKLLQLSSK
Sbjct: 301 SLSSNLYEEVENNKKWTENQFLKYRKDHLGHINECLKVLQEKLEKSENKMEEKLLQLSSK 360
Query: 361 VENFINTQKQETQLSKVKHMENKLSKKMEQMEKQIWGELETMQNEYQSGFKSIHDSLSSL 420
VENFINTQKQETQLSKVKHMENKLSKKMEQMEKQIWGELETMQNEYQSGFKSIHDSLSSL
Sbjct: 361 VENFINTQKQETQLSKVKHMENKLSKKMEQMEKQIWGELETMQNEYQSGFKSIHDSLSSL 420
Query: 421 QQIQKTKMDLEKYKVQKDLKKLQRKIVELQEV 452
QQIQKTKMDLEKYKVQKDLKKLQRKIVELQEV
Sbjct: 421 QQIQKTKMDLEKYKVQKDLKKLQRKIVELQEV 452
>gi|148613880 hypothetical protein LOC145773 [Homo sapiens]
Length = 368
Score = 215 bits (548), Expect = 6e-56
Identities = 116/332 (34%), Positives = 203/332 (61%)
Query: 113 QLEDRLNNQARTIAFLLEQAFRIKEDISACLQGTHGFRKEESLARKLLESHIQTITSIVK 172
QLEDR+ +T A L+E AFRIK+DI LQ + LAR LE HI+ IT+IVK
Sbjct: 32 QLEDRILCHEKTTAALVEHAFRIKDDIVNSLQKMQNKGGGDRLARLFLEEHIRNITAIVK 91
Query: 173 KLSQNIEILEDQIRARDQAATGTNFAVHEINIKHLQGVGDLRGRVARCDSSIVKLSGDIH 232
+L+++IE+L++QIRARD + GTN A+ + ++ L G+GDLRGRVARCD+SI +LS +
Sbjct: 92 QLNRDIEVLQEQIRARDNISYGTNSALKTLEMRQLSGLGDLRGRVARCDASIARLSAEHK 151
Query: 233 LFRQEHRQIEKAIQEFVPALETLSKNLDMKVMQLLGKIETASSEQTSNLKMVQGDYRHEM 292
+ + + K Q LET K+ + ++ QLL +++ + SEQ++ LKM D H++
Sbjct: 152 TTYEGLQHLNKEQQAAKLILETKIKDAEGQISQLLNRVDLSISEQSTKLKMSHRDSNHQL 211
Query: 293 NLLEFKFHSLSSNLYEEVENNKKWTENQFLKYRKDHLGHINECLKVLQEKLEKSENKMEE 352
LL+ KF L ++ + + W + + + K+ L I++ +++E SE ME+
Sbjct: 212 QLLDTKFKGTVEELSNQILSARSWLQQEQERIEKELLQKIDQLSLIVKENSGASERDMEK 271
Query: 353 KLLQLSSKVENFINTQKQETQLSKVKHMENKLSKKMEQMEKQIWGELETMQNEYQSGFKS 412
KL Q+S++++ QK+ + + E K+ ++ ++E Q+ ++ M+ E +GF +
Sbjct: 272 KLSQMSARLDKIEEGQKKTFDGQRTRQEEEKMHGRITKLELQMNQNIKEMKAEVNAGFTA 331
Query: 413 IHDSLSSLQQIQKTKMDLEKYKVQKDLKKLQR 444
+++S+ SL+Q+ + KM L++ ++QK ++ +Q+
Sbjct: 332 VYESIGSLRQVLEAKMKLDRDQLQKQIQLMQK 363
>gi|31982906 cingulin-like 1 [Homo sapiens]
Length = 1302
Score = 64.7 bits (156), Expect = 2e-10
Identities = 105/506 (20%), Positives = 215/506 (42%), Gaps = 85/506 (16%)
Query: 24 KNIKSTKNKAGKASIMSSDTNVNKSASPTATAEEQPVEPDGPLPGSDNNQEK--KVRLSP 81
+NIK + + +A++ + N+ +T +++ E +G L N E+ +V++
Sbjct: 638 QNIKEERERM-RANLEELRSQHNEKVEENSTLQQRLEESEGELR---KNLEELFQVKMER 693
Query: 82 AKMSTKNSTDLVEYVDKSHAFLPIIPNTQ---RGQLEDRLNNQARTIAFLL------EQA 132
+ T+ DL + + + H L ++ +G L + L + + LL E
Sbjct: 694 EQHQTE-IRDLQDQLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQEDL 752
Query: 133 FRIKEDISACLQGT-----HGFRKEESLARKLLESHIQTITSIVKKLSQNIEILEDQIRA 187
R +E L+G +E ++ ++ +Q + V++ ++N+E+L +
Sbjct: 753 LRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNT 812
Query: 188 RDQAATGTNFAVHEINIKH--LQGVGD-LRGRVARCDSSIVKLSGD-------IHLFRQE 237
+Q GT V + ++ LQG + L RVA+ I L GD + + E
Sbjct: 813 SEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGE 872
Query: 238 HRQIEKAI-------QEFVPALETLSKNLD----------MKVMQLLGKIETASSEQTSN 280
RQ+E+A+ +E V A L L+ + QL K++ SEQ
Sbjct: 873 IRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKE-ESEQKEQ 931
Query: 281 LKMVQGDYRHEMNLLEFKFHSLSSNLYEEVENNKKWT---ENQFLKYRKDHLGHINECLK 337
L+ ++ + +E L L + + VE ++ T +NQ +Y++ + + E +
Sbjct: 932 LRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQR 991
Query: 338 VLQEKLEKSEN------KMEEKLLQLSSKVENFINTQKQ---------------ETQLSK 376
L+EK ++E KM++++ + ++ ++ Q + E +L
Sbjct: 992 QLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEA 1051
Query: 377 VKHMEN---KLSKKMEQMEKQIWGELETMQNEYQSGFKSIHDSLSSLQQIQK-------T 426
H+++ +L K+ME Q+ ELE +N + I S ++Q++
Sbjct: 1052 KSHLKDDRSRLVKQMEDKVSQLEMELEEERNNSDLLSERISRSREQMEQLRNELLQERAA 1111
Query: 427 KMDLE--KYKVQKDLKKLQRKIVELQ 450
+ DLE K +++ K L+ +I+ L+
Sbjct: 1112 RQDLECDKISLERQNKDLKSRIIHLE 1137
>gi|83715968 sarcoma antigen NY-SAR-79 [Homo sapiens]
Length = 1079
Score = 61.6 bits (148), Expect = 1e-09
Identities = 71/342 (20%), Positives = 147/342 (42%), Gaps = 28/342 (8%)
Query: 115 EDRLNNQARTIAFLLEQAFRI-KEDISACLQGTHGFRKEESLARKLLESHIQTITSIVKK 173
++ L NQ T+A ++A + K+ + + + + LA ++ E I+ + +K
Sbjct: 69 KETLQNQKETLAEQHKEAMAVFKKQLQMKMCALEEEKGKYQLATEIKEKEIEGLKETLKA 128
Query: 174 LSQNIEILEDQIRARDQAATGTNFAVHEINIKHLQGVGDLRGRVARCDSSIVKLSGDIHL 233
L + L+ ++ +Q HL D +++ + ++G L
Sbjct: 129 LQVSKYSLQKKVSEMEQKVQ-----------LHLLAKEDYHKQLSEIEKYYATITGQFGL 177
Query: 234 FRQEHRQIEKAIQEFVPA---LETLSKNLDMKVMQLLGKIETASSEQTSNLKMVQ---GD 287
++ H ++E+ ++E + + L L+K + ++ L +++ A+S+ + Q G+
Sbjct: 178 VKENHEKLEQNVREAIQSNKRLSALNKKQEAEICSLKKELKKAASDLIKSKVTCQYKMGE 237
Query: 288 YRHEMNLLEFKFHSLSSNLYEEVENNKKWTE--NQFLKYRKDHLGHINECLKVLQEKLEK 345
+ + E KF L L E+E N+K E + ++D + ++L+++++
Sbjct: 238 ENINLTIKEQKFQELQERLNMELELNEKINEEITHIQEEKQDIIISFQHMQQLLRQQIQ- 296
Query: 346 SENKMEEKLLQLSSKVENFINTQKQETQLSKVKHMENKLSKKMEQMEKQIWGELETMQNE 405
+ +ME +L L K N + E Q KVK E K + EK + G + E
Sbjct: 297 ANTEMEAELKVL--KENNQTLERDNELQREKVKENEEKFLNLQNEHEKAL-GTWKRHAEE 353
Query: 406 YQSGFKSIHDSLSSLQQ----IQKTKMDLEKYKVQKDLKKLQ 443
I + LSSL++ +Q+ L K ++ KK Q
Sbjct: 354 LNGEINKIKNELSSLKETHIKLQEHYNKLCNQKTFEEDKKFQ 395
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 60.8 bits (146), Expect = 2e-09
Identities = 97/472 (20%), Positives = 196/472 (41%), Gaps = 62/472 (13%)
Query: 1 MQLQFLGTLASSEKRKKSQRLFFKNIKSTKNKAGKASIMSSDTNVNKSASPTATAEEQPV 60
++LQ G A + + K ++ K + DT + P + V
Sbjct: 576 LKLQLQGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAV 635
Query: 61 EPDGPLPGSDNNQEKKVRLSPAKMSTKNSTDLVEYVDKSHAFLPIIPNTQRGQLEDRLNN 120
E + + +++ L+ A + K++ + DKS + +P I + +LE
Sbjct: 636 EKEQASTEHQSRTSEEISLNDAGVELKSTK---QDGDKSLSAVPDIGQCHQDELE----- 687
Query: 121 QARTIAFLLEQAFRIKEDISACLQGTHGFRKEESLARKLLESHIQTITSIVKKLSQNIEI 180
R+K I L+ F K + + K L+ + I++ L+Q IE
Sbjct: 688 -------------RLKSQI---LELELNFHKAQEIYEKNLDEKAKEISN----LNQLIEE 727
Query: 181 LEDQIRARDQAATGTNFAVHEI--NIKHLQGVGDLRGRVARCDSSIVKLSGDIHLFRQEH 238
+ A T + ++ +K L V +LR +V + + ++ + L +
Sbjct: 728 FKKNADNNSSAFTALSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQRRLDYESQ 787
Query: 239 RQIEKAIQEFVPALETLSKNLDMKVMQL---LGKIETASSEQTSNLKMVQGDYRH-EMNL 294
+ + E + +L +K+ D+K+ L L ++ SEQ++ ++ +Q ++ E +
Sbjct: 788 TAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEV 847
Query: 295 LE---------FKFHSLSSNLYE-EVENNKKWTENQFLKYRKDHLGHINECLKVLQEKLE 344
LE K LS L + E+E K +Q L +K + + + ++ +++
Sbjct: 848 LEGAERVRHISSKVEELSQALSQKELEITKM---DQLLLEKKRDVETLQQTIEEKDQQVT 904
Query: 345 KSENKMEEKLLQLSSKVENFINTQKQETQLSKVKHMENKLSKKMEQMEKQIWGELETMQN 404
+ M EK++QL+ E F ++ +K N LS+ E ++Q+ + N
Sbjct: 905 EISFSMTEKMVQLNE--EKF----SLGVEIKTLKEQLNLLSRAEEAKKEQVEED-----N 953
Query: 405 EYQSGFKSIHDSLSSLQQIQKTKM----DLEKYKVQKDLKKLQRKIVELQEV 452
E SG K +D +S QI K ++ DL K + ++ +KLQ ++ +E+
Sbjct: 954 EVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALINRKEL 1005
Score = 43.9 bits (102), Expect = 3e-04
Identities = 73/380 (19%), Positives = 171/380 (45%), Gaps = 28/380 (7%)
Query: 73 QEKKVRLSPAKMSTKNSTDL-VEYVDKSHAFLPIIPNTQRG-QLEDRLNNQARTIAFLLE 130
+E+K +L K TK +++ EY++K N +L++ L + + + L +
Sbjct: 1969 EEEKQQL--VKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQK 2026
Query: 131 QAFRIKEDISACLQGTHGFRKEESLARKLLESHIQTITSIVK-KLSQNIEILEDQIRARD 189
R +E ISA + ++ ++K LE + + V+ + E+ ++ D
Sbjct: 2027 DCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLLDD 2086
Query: 190 QAATGTNFAVHEINIK-HLQGVGD-LRGRVARCDSSIVKLSGDIHLFRQEHRQIEKAIQE 247
+ + +K LQ + ++ ++ + D + + + ++H + +K +QE
Sbjct: 2087 TQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERR---LEQAEEKHLKEKKNMQE 2143
Query: 248 FVPALETLSKNLDMKVMQLLGKIETASSEQTSNLKMVQGDYRHEMNLLEFKFHSLSSNLY 307
+ AL +L+ + +G+I+ +++ ++ +Q + + L S+SS
Sbjct: 2144 KLDALRREKVHLE----ETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQD 2199
Query: 308 EE---VENNKKWTENQF---LKYRKDHLGHINECLKVLQEKLEKSENKMEEKLLQLSSKV 361
+ ++ KKW E +F ++ +++ + + VL+++L + MEE + +S ++
Sbjct: 2200 DRDRVIDEAKKW-ERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINIS-RL 2257
Query: 362 ENFINTQKQETQLSKVKHMENKLSKKMEQMEKQIWGELETMQNEY---QSGFKSIHDSLS 418
E+ + Q E++ ++ K+ ++ K++ +LE ++ Y Q+ + L
Sbjct: 2258 EH--DKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESELK 2315
Query: 419 SLQ-QIQKTKMDLEKYKVQK 437
SL+ Q+ LEK K QK
Sbjct: 2316 SLKDQLTDLSNSLEKCKEQK 2335
Score = 42.7 bits (99), Expect = 7e-04
Identities = 75/398 (18%), Positives = 163/398 (40%), Gaps = 32/398 (8%)
Query: 73 QEKKVRLSPAKMSTKNSTDLVEYVDKSHAFLPIIPNTQRGQLEDRLNNQARTIAFLLEQA 132
Q K++ ++ K S+ E KS QL++++N Q I L +
Sbjct: 1310 QLKEIEAEKVELELKVSSTTSELTKKSEEVF---------QLQEQINKQGLEIESLKTVS 1360
Query: 133 FRIKEDISACLQGTHGFRKEESLARKL--LESHIQTITSIVKKLSQNIEILEDQIRARDQ 190
+ + Q + + + L L+ + + ++ K +++ L Q+ ++
Sbjct: 1361 HEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEA 1420
Query: 191 AATGTNFAVHE----INIKHLQGVGDLRGRVARCDSSIVKLSGDIHLFRQEHRQI---EK 243
A T + E I H Q L + D I +L ++ +Q+ +I +
Sbjct: 1421 ALTKIQTEIIEQEDLIKALHTQ----LEMQAKEHDERIKQLQVELCEMKQKPEEIGEESR 1476
Query: 244 AIQEFVPALET--LSKNLDMKVMQLLGKIETASSEQTSNLKMVQGDYRHEMNLLEFKFHS 301
A Q+ L+ +S+ +K + L + + + L D +++ + +
Sbjct: 1477 AKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDT 1536
Query: 302 LSSNL-YEEVENNKKWTENQFLKYRKDHLGHINECLKVLQEKLEKSENKMEEKLLQL-SS 359
+ L + E +K TE L E LK+ E L + + K+ +++ L SS
Sbjct: 1537 VLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSS 1596
Query: 360 KVENFINTQKQETQLSKVKHMENKLSKKMEQMEKQIWGELETMQNEYQSGFKSIHDSLSS 419
K+ Q++ +L K + + + + ++I +E ++ E Q + + + ++
Sbjct: 1597 KIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEAN 1656
Query: 420 LQ----QIQKTKMDLE--KYKVQKDLKKLQRKIVELQE 451
+ Q+Q+ + ++E K K++K K Q+KI+EL+E
Sbjct: 1657 KKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEE 1694
Score = 42.7 bits (99), Expect = 7e-04
Identities = 71/408 (17%), Positives = 161/408 (39%), Gaps = 65/408 (15%)
Query: 85 STKNSTDLVEYVDKSHAFLPIIPNTQRGQLEDRL--NNQARTIAFLLEQAFRIKEDISAC 142
+ K +L++Y + + + I + Q+ LE +L N + LE+ + E+ +
Sbjct: 2526 NAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANED 2585
Query: 143 LQGTHGFRKEESLARKLLESHIQTITSIVKKLSQNIEILEDQ-----------IRARDQA 191
L+ + +EE ++ L I+++ + +L++ + L+++ ++ +
Sbjct: 2586 LRRSFNALQEE---KQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVH 2642
Query: 192 ATGTNFAVHEINIKHLQG------------VGDLRGRVARCDSSIVKLSGDIHLFRQEHR 239
F+ + I L+ VG++ ++ + + L D + R E
Sbjct: 2643 RLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKK---ELKHLHHDAGIMRNETE 2699
Query: 240 QIEKAIQEFVPALETLSKNLDMKVMQLLGKIETASS--EQTSNLKMVQGDYRHEMNLLEF 297
E+ + E L + + L M + G S S+L+ + E++ L+
Sbjct: 2700 TAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKR 2759
Query: 298 KFHSLSSNLYEEVENNKKWTENQFL---------KYRKDHLGHINECLKVLQEKLEKSEN 348
K+ + L + E E L ++ L H+ EKL +
Sbjct: 2760 KYDASLKELAQLKEQGLLNRERDALLSETAFSMNSTEENSLSHL--------EKLNQQLL 2811
Query: 349 KMEEKLLQLSSKVENFINTQKQETQLSKVKHMENKLSKKMEQMEKQIWGELETMQNEYQS 408
+E+LL LSS++E+ N + +K ++ +W ELE + +
Sbjct: 2812 SKDEQLLHLSSQLEDSYNQVQS----------FSKAMASLQNERDHLWNELEKFRKSEEG 2861
Query: 409 GFKSIHDSLSSLQQIQKTK-----MDLEKYKVQKDLKKLQRKIVELQE 451
+S +S ++Q K + ++ ++ K+LK LQ++ +++ +
Sbjct: 2862 KQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQ 2909
Score = 41.6 bits (96), Expect = 0.001
Identities = 69/377 (18%), Positives = 157/377 (41%), Gaps = 56/377 (14%)
Query: 113 QLEDRLNNQARTIAFLLEQAFRIKEDISACLQGTHGFRKEESLARKLLESHIQTITSIVK 172
Q + ++N+A I ++E + K+++ L+ T +KE + E ++ + ++
Sbjct: 1620 QSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMR 1679
Query: 173 KL--SQNIEILE-----DQIRARDQAATGTNFAVHEINIKHLQGVGDLRGRVARCDSSIV 225
K S+ +ILE D++RA A T E L ++ + R
Sbjct: 1680 KFAKSKQQKILELEEENDRLRAEVHPAGDT---AKECMETLLSSNASMKEELERVKMEYE 1736
Query: 226 KLSGDIHLFRQEHRQIEKAIQEFVPALE-TLSKNLDMKVMQLLGKIETASSEQTSNLKMV 284
LS E + + +Q+ +E +SK +++ + K + ++ + +
Sbjct: 1737 TLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATE---KHDNQTNVTEEGTQSI 1793
Query: 285 QGDYRHEMNLLEFKFHSLSSNLYEEVENN----KKWTENQFLKYRKDHLGHINECLKVLQ 340
G+ + +L + S ++ N K ++ + + + + E + L+
Sbjct: 1794 PGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLE 1853
Query: 341 EKLEKS-------ENKMEEKLLQLSSK------------VENFINTQKQETQLSKVKHME 381
E+ +K+ EN+ L Q+S+K N +N Q QE +LS+V ++
Sbjct: 1854 EEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQE-ELSRVTKLK 1912
Query: 382 NKLSKKMEQMEKQIWGELETM----------------QNE-YQSGFKSIHDSLSSLQQIQ 424
++ + +E+++ +L + +NE +S K++ +S L++ +
Sbjct: 1913 ETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEE-E 1971
Query: 425 KTKMDLEKYKVQKDLKK 441
K ++ EK KV+ +++K
Sbjct: 1972 KQQLVKEKTKVESEIRK 1988
Score = 28.9 bits (63), Expect = 10.0
Identities = 41/216 (18%), Positives = 91/216 (42%), Gaps = 9/216 (4%)
Query: 236 QEHRQIEKAIQEFVPALETLSKNLDMKVMQLLGKIETASSEQTSNLKMVQGDYRHEMNLL 295
+E +IEK I+ + E L L ++ Q + SS + M++ + + +
Sbjct: 141 EEEMEIEK-IKHKLQEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFI 199
Query: 296 EFKFHSLSSNLYEEVENNKKWTENQFLKYRKDHLGHINECLKVLQEKLEKSENKMEEKLL 355
LS E+ ++ + ++ H +E L+++ + E +M++KL
Sbjct: 200 STLQAQLSQTQAEQAA--QQVVREKDARFETQVRLHEDELLQLVTQA--DVETEMQQKLR 255
Query: 356 QLSSKVENFINTQKQETQLSKVKHMENKLSKKMEQMEKQIWGELETMQNEYQSGFKSIHD 415
L K+E + Q+ + E +++ Q+ Q +L+ M+ E+ + ++ +
Sbjct: 256 VLQRKLEEHEESLVGRAQVVDLLQQELTAAEQRNQILSQ---QLQQMEAEHNT-LRNTVE 311
Query: 416 SLSSLQQIQKTKMDLEKYKVQKDLKKLQRKIVELQE 451
+ +I KM+LE + + LQ ++ L E
Sbjct: 312 TEREESKILLEKMELEVAERKLSFHNLQEEMHHLLE 347
>gi|114155142 nuclear pore complex-associated protein TPR [Homo
sapiens]
Length = 2363
Score = 59.7 bits (143), Expect = 5e-09
Identities = 95/522 (18%), Positives = 215/522 (41%), Gaps = 88/522 (16%)
Query: 1 MQLQFLGTLASSEKRKKSQRLFFKNIKSTKNKAGKASIMSSDT-------------NVNK 47
+QL+ L E+ +KS++ + + S + I+ S T +V+
Sbjct: 579 LQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSL 638
Query: 48 SASPTATAEEQPVEPDGPLPGSDNNQEKKVRLSPAKMSTKNSTDLVEYVDKSHAFLPIIP 107
+++P + Q V P+P ++ + + AK + K ++ E K A I
Sbjct: 639 ASTPKRPSTSQTVSTPAPVPVIESTEAIE-----AKAALKQLQEIFENYKKEKAENEKIQ 693
Query: 108 NTQRGQLEDR---LNNQARTIAFLLEQAFRIKEDISACLQG-------THGFRKEESLAR 157
N Q +L+++ L +Q I+ L+ A + E + ++G H ++ +
Sbjct: 694 NEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATT 753
Query: 158 KLLESHIQTITSIVKKLSQNIEILEDQIRARDQAATGTNFAVHEINIKH----------- 206
+ E I T+T ++ ++ + + E +RA + + E+ +
Sbjct: 754 QKQEQIINTMTQDLRGANEKLAVAE--VRAENLKKEKEMLKLSEVRLSQQRESLLAEQRG 811
Query: 207 ----LQGVGDLRGRVARCDSSIV-KLSGDIHLFRQEHRQIEKAIQEFVPALETLSKNLDM 261
L + ++G + R ++ +LS I E ++K ++ V TL++NLD+
Sbjct: 812 QNLLLTNLQTIQGILERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDV 871
Query: 262 KVMQLLGKIETASS------EQTSNLKMVQGDYRHEMNLLEFKFHSLSSNLYEEVENNKK 315
+++ +++T ++ E N + + ++ +E + S SS + + + K
Sbjct: 872 QLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNK 931
Query: 316 WTENQFLKYRKDHLGHINECLKVLQEKLEKSENKMEEKLLQLSSKVENFINTQKQ----- 370
+ + + +N+ L+E+L+ S + +E+ ++S +E +N +KQ
Sbjct: 932 EDVDDLVSQLRQTEEQVND----LKERLKTSTSNVEQYQAMVTS-LEESLNKEKQVTEEV 986
Query: 371 ----ETQLSKVKHMENKLSKKMEQMEKQ---------------------IWGELETMQNE 405
E +L + + +L KK+ ++EK+ + L ++QNE
Sbjct: 987 RKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNE 1046
Query: 406 YQSGFKSIHDSLSSLQQIQKTKMDLEKYKVQKDLKKLQRKIV 447
Q + +LS+ QQ ++ + K V+ K +R+++
Sbjct: 1047 VQEALQRASTALSNEQQARRDCQEQAKIAVEAQ-NKYERELM 1087
Score = 43.9 bits (102), Expect = 3e-04
Identities = 99/499 (19%), Positives = 205/499 (41%), Gaps = 86/499 (17%)
Query: 13 EKRKKSQRLFFKNIKSTKNKAGKASIMSSDTNVNKSASPTATAEEQPVEPDGPLPGSDNN 72
E +K RL I+ +K + +N S S ++EQ +E +
Sbjct: 1150 EDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFI-----R 1204
Query: 73 QEKKV---RLSPAKMSTKNSTDLVEYVDKSHAFLPIIPNTQRGQLEDRLNNQARTIAFLL 129
+EK++ R A++ + VE +++ L N +R +++ A+T+A
Sbjct: 1205 REKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAER----EKVQVTAKTMA-QH 1259
Query: 130 EQAFRIKEDISACLQGTHGFRKEESLARKLLESHIQTITSIVKKLSQNI----------- 178
E+ + E ++ ++ R+E ++ LE +Q + + V+KL +I
Sbjct: 1260 EELMKKTETMNVVMETNKMLREE----KERLEQDLQQMQAKVRKLELDILPLQEANAELS 1315
Query: 179 ----------EILEDQIR---ARDQAATGTN-----------FAVHEINIKHLQG----V 210
++LE+ ++ AR+Q + E++ K +Q +
Sbjct: 1316 EKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEI 1375
Query: 211 GDLRGRVARCDSSIVKLSGDIHLFRQEHRQIEKAIQEFVPALETLSKNLDMKVMQLLGKI 270
G L+ +AR ++S+ I +++ ++ ET+ K+LD K++ + K+
Sbjct: 1376 GRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTE-------KETIQKDLDAKIIDIQEKV 1428
Query: 271 ETAS---------SEQTSNLKMVQGDYRHEMNLLEFKFHSLSSNLYEEVENNKKWTENQF 321
+T + Q LK Q D E + H +E++ K+ T NQ
Sbjct: 1429 KTITQVKKIGRRYKTQYEELK-AQQDKVMETSAQSSGDHQEQHVSVQEMQELKE-TLNQA 1486
Query: 322 LKYRKDHLGHINECLKVLQEKLEKSENKMEEKLLQLSSKV----ENFINTQKQETQL-SK 376
K + K L EK ++ N ++E+ +QL S++ ++ + QE QL +
Sbjct: 1487 ETKSKSLESQVENLQKTLSEKETEARN-LQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQ 1545
Query: 377 VKHMENKLSKKMEQMEKQIWGELETMQNEYQSGFKSIHDSLSSLQQIQKTKMDLE----K 432
+ E K K + + +I L ++++ + + +L Q QK ++D+ K
Sbjct: 1546 ITEKEEKTRKAIVAAKSKI-AHLAGVKDQLTKENEELKQRNGALDQ-QKDELDVRITALK 1603
Query: 433 YKVQKDLKKLQRKIVELQE 451
+ + + +L+R++ E QE
Sbjct: 1604 SQYEGRISRLERELREHQE 1622
Score = 35.8 bits (81), Expect = 0.082
Identities = 63/368 (17%), Positives = 145/368 (39%), Gaps = 46/368 (12%)
Query: 70 DNNQEKKVRLSPAKMSTKNSTD-LVEYVDKSHAFLPIIPNTQRGQLEDRLNNQART---I 125
+N +E+ RL K S + L ++V+ L Q+ +E++ +N+ +
Sbjct: 227 ENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKE-QQASMEEKFHNELNAHIKL 285
Query: 126 AFLLEQAFRIKE----DISACLQGTHGFRKEESLARKLLESHI----QTITSIVKKLSQN 177
+ L + A E +++ ++ H KE A K ++ H+ Q+ + K++ +
Sbjct: 286 SNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEK 345
Query: 178 IEILEDQIRARDQAATGTNFAVHEINIKHLQGVGDLRGRVARCDSSIVKLS--------- 228
I LE ++ + + T ++ + L + VA+ +KL+
Sbjct: 346 IGRLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVET 405
Query: 229 -GDIHLFRQEHRQIEKAIQEFVPALETLSK-----------------NLDMKVMQLLGKI 270
+ L + E+++I K + E V +E + +L +K+ Q + +I
Sbjct: 406 QDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEI 465
Query: 271 ETASSEQTSNLKMVQGDYRHEMNLLEFKFHSLSSNLYEEVENNKKWTENQFLKYRKDHLG 330
+ E T + +E + LS + + ++ N ++ +
Sbjct: 466 QRLQ-EDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSA 524
Query: 331 HINECLKVLQEKLEKSEN-----KMEEKLLQLSSKVENFINTQKQETQLSKVKHMENKLS 385
I+ +V+ + L N + ++LL ++ ++QET SK+ ++ KL
Sbjct: 525 DISSSSEVISQHLVSYRNIEELQQQNQRLLVALRELGETREREEQETTSSKITELQLKLE 584
Query: 386 KKMEQMEK 393
+ ++E+
Sbjct: 585 SALTELEQ 592
Score = 32.3 bits (72), Expect = 0.90
Identities = 58/307 (18%), Positives = 142/307 (46%), Gaps = 32/307 (10%)
Query: 151 KEESLARKLLESHIQTITSIVKKLSQNIEILEDQIR-ARDQAATGTNFAVHEINIKHLQG 209
K+E ++R LE + + + + L +++E L +++ A++Q A+ +E+N H++
Sbjct: 229 KKEEVSR--LEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNA-HIK- 284
Query: 210 VGDLRGRVA----RCDSSIVKLSGDIHLFRQEHRQIEKAIQEFVPALETLSKNLDMKVMQ 265
+ +L A + + + ++H +E + KAIQ+ + +E ++ ++++
Sbjct: 285 LSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLE 344
Query: 266 LLGKIETASSEQTSNLKMVQGDYRHEMNLLEFKFHSLSSNLYEEVENNKKWTENQFLKYR 325
+G++E E + ++ R L E + ++S + K +K
Sbjct: 345 KIGRLE---KELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPG-----MKLT 396
Query: 326 KDHLGHINECLKVLQEKLE-KSENKMEEKLLQLSSKVENFINTQKQETQLSKVKHMENKL 384
+ + ++ ++L EKLE K NK +++++ + Q++E + + + L
Sbjct: 397 ELYNAYVETQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYE--RAQKAVASL 454
Query: 385 SKKMEQMEKQIWGELETMQNEYQSGFKSIHDSLSSLQQIQKTKMDLEKYKVQKDLKKLQR 444
S K+EQ K E++ +Q + K SS+ + +M+++ + + ++ L
Sbjct: 455 SVKLEQAMK----EIQRLQEDTDKANKQ-----SSVLERDNRRMEIQVKDLSQQIRVL-- 503
Query: 445 KIVELQE 451
++EL+E
Sbjct: 504 -LMELEE 509
Score = 31.2 bits (69), Expect = 2.0
Identities = 63/340 (18%), Positives = 128/340 (37%), Gaps = 75/340 (22%)
Query: 116 DRLNNQARTIAFLLEQAFRIKEDISACLQGTHGFRKEESLARKLLESHIQTITSIVKKLS 175
++LNNQ + + ++ I +D + +Q KEE LE+ + + ++LS
Sbjct: 83 EKLNNQLKALTEKNKE-LEIAQDRNIAIQSQFTRTKEE------LEAEKRDLIRTNERLS 135
Query: 176 QNIEILEDQIRARDQAATGTNFAVHEINIKHLQGVGDLRGRVARCDSSIVKLSGDIHLFR 235
Q +E L + ++ ++ +N E+ +K + +L+ +L + L
Sbjct: 136 QELEYLTEDVKRLNEKLKESNTTKGELQLK----LDELQASDVSVKYREKRLEQEKELLH 191
Query: 236 QEHRQIEKAIQEFVPALETLSKNLDMKVMQLLGKIETASSEQTSNLKMVQGDYRHEMNLL 295
++ + ++ L L + ++++L +E E+ S L+ +MN L
Sbjct: 192 SQNTWLNTELKTKTDELLALGREKGNEILELKCNLEN-KKEEVSRLE-------EQMNGL 243
Query: 296 EFKFHSLSSNLYEEVENNKKWTENQFLKYRKDHLGHINECLKVLQEKLEKSENKMEEKLL 355
+ T N+ L+ H+ + L L+E E+ + MEEK
Sbjct: 244 K--------------------TSNEHLQK------HVEDLLTKLKEAKEQQAS-MEEKF- 275
Query: 356 QLSSKVENFINTQKQETQLSKVKHMENKLSKKMEQMEKQIWGELETMQNEYQSGFKSIHD 415
H E K+ + K + E NE + +H
Sbjct: 276 -----------------------HNELNAHIKLSNLYKSAADDSEAKSNELTRAVEELHK 312
Query: 416 SLSSL----QQIQKTKMDLEKYKVQKDLKKLQRKIVELQE 451
L + IQ +++E+ K Q + K++ KI L++
Sbjct: 313 LLKEAGEANKAIQDHLLEVEQSKDQME-KEMLEKIGRLEK 351
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 56.6 bits (135), Expect = 4e-08
Identities = 68/328 (20%), Positives = 140/328 (42%), Gaps = 37/328 (11%)
Query: 136 KEDISACLQGTHGFRKEESLARKLLESHIQTITSIVKKLSQNIEILEDQIRARDQAATGT 195
K+ + A +Q EE AR+ L+ T + +KK+ + I +LEDQ
Sbjct: 945 KKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQ----------- 993
Query: 196 NFAVHEINIKHLQGVGDLRGRVARCDSSIVKLSGDIHLFRQEHRQIEKAIQEFVPALETL 255
N K ++ + R+A C S + + + + E I + L+
Sbjct: 994 -------NSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKK- 1045
Query: 256 SKNLDMKVMQLLGKIETASSEQTSNLKMVQGDYRHEMNLLEFKFHSLSSNLYEEVENNKK 315
+ K Q L K + +T++L+ + + +++ L+ + L +
Sbjct: 1046 ----EEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDD 1101
Query: 316 WT--ENQFLKYRKDHLGHINECL------KVLQEKLEKSENKMEEKLLQLSSKVENFINT 367
T +N LK ++ I E K + K EK + + E+L L +++E+ ++T
Sbjct: 1102 ETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDT 1161
Query: 368 QKQETQLSKVKHME-NKLSKKMEQMEKQIWGELETMQNEYQSGFKSIHDSLSSLQQIQKT 426
+ +L + E +L K +E+ K +++ M+ + + + + + L+Q ++
Sbjct: 1162 TAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSE---QLEQAKRF 1218
Query: 427 KMDLEKYK--VQKDLKKLQRKIVELQEV 452
K +LEK K ++ D K+L ++ LQ+V
Sbjct: 1219 KANLEKNKQGLETDNKELACEVKVLQQV 1246
Score = 48.5 bits (114), Expect = 1e-05
Identities = 65/344 (18%), Positives = 150/344 (43%), Gaps = 34/344 (9%)
Query: 121 QARTIAFLLEQAFRIKEDISACLQGTHGFRKEESLARKLLESHIQTITSIVKKLSQNIEI 180
+A+ +A + + + D+ L+ R+E A++ L+ + + +L I+
Sbjct: 1021 KAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDE 1080
Query: 181 LEDQIRARDQA-----ATGTNFAVHEINIKHLQGVGDLRGRVARCDSSIVKLSGDIHLFR 235
L+ Q+ +++ A G + +H+ N L+ V +L+ ++A +
Sbjct: 1081 LKLQLAKKEEELQGALARGDDETLHKNNA--LKVVRELQAQIAELQEDFESEKASRNKAE 1138
Query: 236 QEHRQIEKAIQEFVPALE------TLSKNLDMKVMQLLGKIETASSEQTSNLKMVQGDYR 289
++ R + + ++ LE + L K Q + +++ A E+T N
Sbjct: 1139 KQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKN--------- 1189
Query: 290 HEMNLLEFKFHSLSS--NLYEEVENNKKWTENQFLKYRKDHLGHINECLKVLQEKLEKSE 347
HE + + + ++ L E++E K++ N L+ K L N+ L + L++ +
Sbjct: 1190 HEAQIQDMRQRHATALEELSEQLEQAKRFKAN--LEKNKQGLETDNKELACEVKVLQQVK 1247
Query: 348 NKMEEKLLQLSSKVENFINTQKQETQLSKVKHMENKLSKKMEQMEKQIWGELETMQNEYQ 407
+ E K +L ++V Q+ ++S+ + +L++K +++ ++ ++ +
Sbjct: 1248 AESEHKRKKLDAQV------QELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEK 1301
Query: 408 SGFKSIHDSLSSLQQIQKTKMDLEKYKVQKDLKKLQRKIVELQE 451
G K D+ S Q+Q T+ L++ QK L +I +L+E
Sbjct: 1302 KGIKFAKDAASLESQLQDTQELLQEETRQK--LNLSSRIRQLEE 1343
Score = 38.5 bits (88), Expect = 0.013
Identities = 85/463 (18%), Positives = 190/463 (41%), Gaps = 77/463 (16%)
Query: 13 EKRKKSQRLFFKNIKSTKNKAGKASIMSSDTNVNKSASPTATAEEQPVEPDGPLPGSDNN 72
E++ K R +++ S+K+ GK NV++ E+Q E L ++
Sbjct: 1503 ERQNKQLRADMEDLMSSKDDVGK--------NVHELEKSKRALEQQVEEMRTQLEELEDE 1554
Query: 73 ----QEKKVRL--SPAKMSTKNSTDLVEYVDKSHAFLPIIPNTQR---GQLEDRLNNQAR 123
++ K+RL + M + DL +++ ++ R +LED +A
Sbjct: 1555 LQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRAL 1614
Query: 124 TIAFLLEQAFRIKEDISACLQGTHGFRKEESLARKLLESHIQTITSIVKKLSQNIEILED 183
+A + +K D+ A ++ A K + I+ + + ++ LE+
Sbjct: 1615 AVASKKKMEIDLK-DLEAQIEA----------ANKARDEVIKQLRKLQAQMKDYQRELEE 1663
Query: 184 QIRARDQAATGTNFAVHEINIKHLQGVGDLRGRVARCDSSIVKLSGDIHLFRQEHRQIEK 243
+RD+ FA + + K L+ + ++ I++L ++ + R E+
Sbjct: 1664 ARASRDEI-----FAQSKESEKKLKSL----------EAEILQLQEELASSERARRHAEQ 1708
Query: 244 AIQEFVP----------ALETLSKNLDMKVMQLLGKIETASSEQTSNLKMVQGDYRHEMN 293
E AL + L+ ++ QL ++E E+ SN++++ +R
Sbjct: 1709 ERDELADEITNSASGKSALLDEKRRLEARIAQLEEELE----EEQSNMELLNDRFRKTT- 1763
Query: 294 LLEFKFHSLSSNLYEEVENNKKW--TENQFLKYRKDHLGHINECLKVLQEKLEKSENKME 351
+ +L++ L E +K Q + K+ + E ++ K + + + +E
Sbjct: 1764 ---LQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALE 1820
Query: 352 EKLLQLSSKVENFINTQKQETQLSKVKHMENKLSKKMEQMEKQIWGELETMQ---NEYQS 408
K+ QL ++E Q +K + NKL ++ E+ K+I+ ++E + ++Y+
Sbjct: 1821 AKIGQLEEQLE----------QEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKE 1870
Query: 409 GFKSIHDSLSSLQQIQKTKMDLEKYKVQKDLKKLQRKIVELQE 451
+ + + L++ Q + + E + +KLQR++ + E
Sbjct: 1871 QMEKANARMKQLKR-QLEEAEEEATRANASRRKLQRELDDATE 1912
Score = 36.2 bits (82), Expect = 0.063
Identities = 70/350 (20%), Positives = 149/350 (42%), Gaps = 49/350 (14%)
Query: 117 RLNNQARTIAFLLEQA----FRIKEDISAC---LQGTHGFRKEESLARKLLESHIQTITS 169
+L N+ ++ LLE+A + +D ++ LQ T +EE+ + L S I
Sbjct: 1284 KLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRI----- 1338
Query: 170 IVKKLSQNIEILEDQIRARDQAATGTNFAVHEINIKHLQGVGDLRGRVARCDSSIVKLSG 229
++L + L++Q ++A + V L+ ++A + G
Sbjct: 1339 --RQLEEEKNSLQEQQEEEEEARKNLE-----------KQVLALQSQLADTKKKVDDDLG 1385
Query: 230 DIHLFRQEHRQIEKAIQEFVPALETLSKNLDMKVMQLLGKIETASSEQTSNLKMVQGDYR 289
I +E+A ++ + E LS+ L+ K + K+E + L + D
Sbjct: 1386 TIE-------SLEEAKKKLLKDAEALSQRLEEKALAY-DKLEKTKNRLQQELDDLTVDLD 1437
Query: 290 HEMNL---LEFKFHSLSSNLYEEVENNKKWTENQF---LKYRKDHLGHINECLKVLQEKL 343
H+ + LE K L EE + ++ E + + R+ ++ + L+E L
Sbjct: 1438 HQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALS-LARALEEAL 1496
Query: 344 EKSENKMEEKLLQLSSKVENFINTQKQETQLSKVKHMENKLSKKMEQMEKQIWGELETMQ 403
E E + E + QL + +E+ ++++ + K H K + +EQ +++ +LE ++
Sbjct: 1497 EAKE-EFERQNKQLRADMEDLMSSKDD---VGKNVHELEKSKRALEQQVEEMRTQLEELE 1552
Query: 404 NEYQSGFKSIHDSLSSLQ-QIQKTKMDLEKYKVQKDLKKLQRKIVELQEV 452
+E Q + D+ L+ +Q K E+ +D + ++K + +++V
Sbjct: 1553 DELQ----ATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQV 1598
Score = 30.0 bits (66), Expect = 4.5
Identities = 26/117 (22%), Positives = 54/117 (46%), Gaps = 22/117 (18%)
Query: 354 LLQLSSKVENFINTQKQETQLSKVKHMENKLSKKMEQMEK---QIWGELETMQNEYQSGF 410
LLQ++ + E Q ++ +L KVK + K+ ++E+ME+ Q+ E + + Q+
Sbjct: 844 LLQVTRQEEEL---QAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAET 900
Query: 411 KSIHDSLSSLQQIQKTKMDLEKYK----------------VQKDLKKLQRKIVELQE 451
+ ++ ++ K +LE+ +Q + KK+Q I +L+E
Sbjct: 901 ELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEE 957
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 56.6 bits (135), Expect = 4e-08
Identities = 82/385 (21%), Positives = 173/385 (44%), Gaps = 53/385 (13%)
Query: 113 QLEDRLNNQARTIAFLLEQAFRIKEDISACLQGTHGFRKE-----ESLARKL--LESHIQ 165
QL++++ N + L++ + ++ A Q T +E E + R++ + IQ
Sbjct: 468 QLKEKVTNSTE-LQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQ 526
Query: 166 TITSIVKKLSQNIEILE---DQIRARDQAATGTNFAVHEINIKH---LQGVGDLRGRVAR 219
+ ++++K +NI +LE + + A+ QA G ++++ K+ + V L ++
Sbjct: 527 NLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKN 586
Query: 220 CDSSIVKLSGDIHLFRQEHRQIEKAIQEFVPALETLSKNLDMKV---------------- 263
S + ++H QE + +A Q+ V +LET L+ ++
Sbjct: 587 QSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKA 646
Query: 264 -MQLLGKIETASSEQTSNLKM-------VQGDYRHEMNLLEFKFHSLSSNLYEEVENNKK 315
+LL E A + Q ++L+ D + E+N + + +++ L ++ E+ +
Sbjct: 647 KTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQ 706
Query: 316 WTENQFLKYRKDHLGHINECLKVLQEKLEKSENKMEEKLLQLSSKVENFINTQKQETQLS 375
E+ +Y++ +L L+ E+LE K+E L++ + E + +Q+ QL+
Sbjct: 707 -LESHLKEYKEKYLS-----LEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLN 760
Query: 376 KVKHME-NKLSKKMEQMEKQIWGELETMQNEYQSGFKSIHDSLSSL-QQIQKTKMDLE-- 431
+ +LSK++E MEK+I + +SI L+ ++ Q K D E
Sbjct: 761 TDLELRATELSKQLE-MEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETL 819
Query: 432 --KYKVQKD--LKKLQRKIVELQEV 452
+ K+Q + ++Q + ELQ+V
Sbjct: 820 SQETKIQHEELNNRIQTTVTELQKV 844
Score = 49.7 bits (117), Expect = 5e-06
Identities = 100/487 (20%), Positives = 186/487 (38%), Gaps = 109/487 (22%)
Query: 12 SEKRKKSQRLFFKNIKSTKN--KAGKASIMSSDTNVNKSASPTATAEEQPVEPDGPLPGS 69
SE K++Q ++ K +A + ++S +T+VN+ S ++E+ + D +
Sbjct: 588 SESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKA- 646
Query: 70 DNNQEKKVRLSPAKMSTKNSTDLVEYVDKSHAFLPIIPNTQRGQLEDRLNNQARTIAFLL 129
+ ++ LS T DL ++D T + L+D+ + I L
Sbjct: 647 ----KTELLLSAEAAKTAQRADLQNHLD-----------TAQNALQDK-QQELNKITTQL 690
Query: 130 EQAFRIKEDISACLQGTHGFRKEESLARKLLESHIQTITSIVKKLSQNIEILEDQIRARD 189
+Q ++A LQ K+E ++ LESH++ L Q E LE QI+ +
Sbjct: 691 DQ-------VTAKLQD-----KQEHCSQ--LESHLKEYKEKYLSLEQKTEELEGQIKKLE 736
Query: 190 QAATGTNFAVHEINIKHLQGVGDLRGRVARCDSSIVKLSGDIHLFRQEHRQIEKAIQEFV 249
+ E+ Q + DL+ + RQ + +E E
Sbjct: 737 ADSL-------EVKASKEQALQDLQQQ------------------RQLNTDLELRATELS 771
Query: 250 PALETLSKNLDMKVMQLLGKIETASSEQTSNLKMVQGDYRHEMNLLEFKFHSLSSNL--- 306
LE + + + L K SE ++K E +L+ F +LS
Sbjct: 772 KQLEMEKEIVSSTRLDLQKK-----SEALESIKQKLTKQEEEKQILKQDFETLSQETKIQ 826
Query: 307 YEEVENNKKWTENQFLKYR-------------KDHLGHINECLKVLQEKLEKSENKMEEK 353
+EE+ N + T + K + KD L +++ LK + + EK K +
Sbjct: 827 HEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAA 886
Query: 354 LL-----------QLSSKVENFINTQKQ-ETQLSKVKHMENKLS---------------- 385
+L QL ++EN + QK+ + L K K ++L
Sbjct: 887 ILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNT 946
Query: 386 -KKMEQMEKQIWGELETMQNEYQSGFKSIHDSLSSLQQIQKTKMDLEKYKVQKDLKKLQR 444
K+ E+ E+Q+ G + ++ + K I L+ K +LE K+Q+ L + +
Sbjct: 947 LKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELEN-KLQQQLTQAAQ 1005
Query: 445 KIVELQE 451
++ +E
Sbjct: 1006 ELAAEKE 1012
Score = 48.1 bits (113), Expect = 2e-05
Identities = 98/487 (20%), Positives = 197/487 (40%), Gaps = 52/487 (10%)
Query: 1 MQLQFLGTLASSEKRKKSQRL-FFKNIKST---KNKAGKASIMSSDTNVNKSASPTATAE 56
M+ + L T S+ K K S+ KN KS +N+ GKA+I+ + +
Sbjct: 846 MEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQM 905
Query: 57 EQPVEPDGPLPGS-----DNNQEKKVRLSPAKMSTKNSTDLVEYVDKSHAFLPIIPNTQR 111
E ++ L S + + + K+ L+ + + + ++ +K L N +
Sbjct: 906 ENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELK 965
Query: 112 GQLEDRLNNQARTIAFLLEQAFRIKEDISACLQGTHGFRKEESLARKLLESHIQTITSIV 171
Q ++ Q + L+ A K ++ LQ +E A K I + +
Sbjct: 966 -QSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEK---EKISVLQNNY 1021
Query: 172 KKLSQNIEILEDQIRARDQAATGTNFAVHEINIKHLQGVGDL---RGRVARCDSSIVKLS 228
+K + + L+ R+ T + + K DL R ++ + I +L
Sbjct: 1022 EKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELK 1081
Query: 229 GDIHLFRQEHRQIEKAIQEFVPALETLSKNLDMKVMQLLGKIETASSEQTSNLKMVQGDY 288
Q+ + E+ +QE AL+ + K +K +L+ E + + +K Q
Sbjct: 1082 TAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVN--EKSKLAEIEEIKCRQEKE 1139
Query: 289 RHEMNLLEFKFHSLSSNLYEEVENNKKWTENQFLKYRKDHLGHINECLK----------- 337
++N E K H L S +E+ N K Q L +K L + LK
Sbjct: 1140 ITKLNE-ELKSHKLES--IKEITNLKD--AKQLLIQQKLELQGKADSLKAAVEQEKRNQQ 1194
Query: 338 VLQEKLEKSENKMEEKLLQLSSKVENFINTQKQETQLSKVKHMENKLSKKME-------- 389
+L+++++K E +++++ ++ +K+ + I +E ++ KH EN+ M+
Sbjct: 1195 ILKDQVKKEEEELKKEFIEKEAKLHSEI----KEKEVGMKKHEENEAKLTMQITALNENL 1250
Query: 390 QMEKQIWGELETMQNEYQSGFKSIHDSLSSLQQIQKTKMD-----LEK-YKVQKDLKKLQ 443
K+ W + +E + + ++ L+ + D LE+ K + +++KLQ
Sbjct: 1251 GTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQ 1310
Query: 444 RKIVELQ 450
K++ELQ
Sbjct: 1311 TKVLELQ 1317
Score = 40.0 bits (92), Expect = 0.004
Identities = 64/338 (18%), Positives = 143/338 (42%), Gaps = 45/338 (13%)
Query: 113 QLEDRLNNQARTIAFLLEQAFRIKEDISACLQGTHGFRKEESLARKLLESHIQTITSIVK 172
+L+ + + TI+ L + + ++++ +Q +K +S +L + + QT+T +
Sbjct: 257 KLQSQYASSEATISQLRSELAKGPQEVAVYVQE---LQKLKSSVNELTQKN-QTLTENLL 312
Query: 173 KLSQNIEILEDQIRARDQAATGTNFAVHEINIKHLQGVGDLRGRVARCDSSIVKLSGDIH 232
K Q+ LE++ + +H+ ++ Q L+ R++ ++S+ + IH
Sbjct: 313 KKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQ----LQSRLSASETSLHR----IH 364
Query: 233 LFRQEHRQIEKAIQEFVPALETLSKNLDMKVMQLLGKIETASSEQTSNLKMVQGDYRHEM 292
+ E + + ++E + +ET ++L + QL + E +H +
Sbjct: 365 VELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKE--------------QHGL 410
Query: 293 NLLEFKFHSLSSNLYEEVENNKKWTENQFLKYRKDHLGHINECLKVLQEKLEKSENKMEE 352
L + + + L S L E TE Q + G + E ++ EKL E ++ +
Sbjct: 411 QL-QSEINQLHSKLLE--------TERQLGEAH----GRLKEQRQLSSEKLMDKEQQVAD 457
Query: 353 KLLQLSSKVENFINTQKQETQLSKVKHMENKLSKKMEQMEKQIWGELETMQNEYQSGFKS 412
L+LS E T+L + ++ + +++ +L QN+ + +
Sbjct: 458 LQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQ 517
Query: 413 IHDSLSSLQQ----IQKTKMDLEKYKVQKDLKKLQRKI 446
I D +Q +QK+K ++ ++K+ + L KI
Sbjct: 518 IGDKDQKIQNLEALLQKSKENIS--LLEKEREDLYAKI 553
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 56.2 bits (134), Expect = 6e-08
Identities = 91/455 (20%), Positives = 194/455 (42%), Gaps = 31/455 (6%)
Query: 15 RKKSQRLFFKNIKSTKNKAGKASIMSSDTNVNKSASPTATAEEQPVEPDGPLPGSDNNQE 74
RKK + L +N+ T A K S M ++ + E P L G + N+
Sbjct: 402 RKKIEELMEENM--TLEMAQKQS-MDESLHLGWELEQISRTSELSEAPQKSL-GHEVNEL 457
Query: 75 KKVRLSPAKMSTKNSTDLVEYVDKSHAFLPIIPNTQRGQLEDRLNNQ--ARTIAFLLEQA 132
RL +M ++ T VE + + + + L+ NQ ++ + L +
Sbjct: 458 TSSRLLKLEMENQSLTKTVEELRTT---VDSVEGNASKILKMEKENQRLSKKVEILENEI 514
Query: 133 FRIKEDISACLQGTHGFRKEESLARKLLESHIQTITSIVKKLSQNIEILEDQI---RARD 189
+ K+ + C + KE++ K +E+ + +K L Q E L + R R
Sbjct: 515 VQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRS 574
Query: 190 QAATGTNFAVHEINIKHL-QGVGDLRGRVARCDSSIVKLSGDIHLFRQEHRQIEKAIQEF 248
Q + E K L + + + ++++ + ++ ++ ++++ + E+ E
Sbjct: 575 QISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENE- 633
Query: 249 VPALETLSKNLDMKVMQLLGKIETASSEQTSNLKMVQGDYRHEMNLLEFKFHSLSSNLYE 308
+ LE ++ L K+ L E + + N ++ + + + + L FK + E
Sbjct: 634 LHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLE 693
Query: 309 EVENNKKWTENQFLKYRKDHLGHINECLKVLQEKLEKSENKMEEKLLQLSSKVE----NF 364
+ EN++ EN L+ + L +C + +L+ ++E + QL +E +F
Sbjct: 694 K-ENSQLDEENLELRRNVESL----KCASMKMAQLQLENKELESEKEQLKKGLELLKASF 748
Query: 365 INTQKQETQLSKVKHMENKLSKKMEQMEK---QIWGELETMQNEYQSGFKSIHD---SLS 418
T++ E + +L K +E K Q+ EL+ ++ E Q+ K++ + S
Sbjct: 749 KKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSK 808
Query: 419 SLQQIQKTKMDLEK--YKVQKDLKKLQRKIVELQE 451
L+Q++K LE+ +++KD K+L+++ L++
Sbjct: 809 RLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQ 843
Score = 43.1 bits (100), Expect = 5e-04
Identities = 64/338 (18%), Positives = 139/338 (41%), Gaps = 50/338 (14%)
Query: 145 GTHGFRKEESLARKLLESHIQTITSIVKKLSQNIEILEDQIRARDQAATGTNFAVHEINI 204
G+ G ++ ES R+ L + + +++L Q +E +Q+ Q + +
Sbjct: 236 GSPGMKRTES--RQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQ 293
Query: 205 KHLQGVGDLRG----------------RVARCDSSIVKLSGDIHLFRQEHRQIEKAIQEF 248
+++ + D R RV + +S + + +H ++E+ ++
Sbjct: 294 ENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDN 353
Query: 249 VPALETLSK----------------NLDMKVMQLLGKIETASSEQTSNLKMVQGDYRHEM 292
LET + L+ + +QL K+ E+ + K ++ M
Sbjct: 354 QVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENM 413
Query: 293 NLLEFKFHSLSSNLYEEVENNKKWTENQFLKYRKDHLGH-INECLKVLQEKLEKSENKME 351
L + S+ +L+ E + ++ + + LGH +NE KLE +
Sbjct: 414 TLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLT 473
Query: 352 EKLLQLSSKVENFINTQKQETQLSKVKHMENKLSKKMEQMEKQIWGELETMQNEYQSGFK 411
+ + +L + V++ + +++ K++ +LSKK+E +E +I E +++QN
Sbjct: 474 KTVEELRTTVDS---VEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQN------- 523
Query: 412 SIHDSLSSLQQIQKTKMDLEK-YKVQKDLKKLQRKIVE 448
+LS + + K K LEK + ++ + Q KI+E
Sbjct: 524 --CQNLS--KDLMKEKAQLEKTIETLRENSERQIKILE 557
Score = 40.4 bits (93), Expect = 0.003
Identities = 89/406 (21%), Positives = 173/406 (42%), Gaps = 52/406 (12%)
Query: 56 EEQPVEPDGPLPGSDNNQEKKVRLSPAKMSTKNSTDLVEYVDKSHAFLPI---IPNTQRG 112
EE+ V+ P+ G DN E++ + + ++ K L+E V++++A L TQ
Sbjct: 1013 EERMVQSSPPISGEDNKWERESQETTREL-LKVKDRLIE-VERNNATLQAEKQALKTQLK 1070
Query: 113 QLEDRLNNQARTIAFLLEQAFRIKEDISACLQGTHGFRKEESLARKLLESHIQTITSIVK 172
QLE + NN I L Q ++E + + E S S + ++
Sbjct: 1071 QLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLI 1130
Query: 173 KLSQNIEILEDQIRARDQAATGTNFAVHEINIKHLQGVGDLRGRVARCDSSIVKLSGDIH 232
+ S E I+ R+ ++++ IK + + L R A S++ G +
Sbjct: 1131 QQSSLENENESVIKEREDLK-----SLYDSLIKDHEKLELLHERQASEYESLISKHGTL- 1184
Query: 233 LFRQEHRQIEKAIQEFVPALETLSKNLDMKVMQLLGKIETASSEQTSNLKMVQGDYRHEM 292
+ H+ LE ++L+ + QLL K + + LK+ Q E
Sbjct: 1185 --KSAHKN-----------LEVEHRDLEDRYNQLL-KQKGQLEDLEKMLKVEQ-----EK 1225
Query: 293 NLLEFKFHSLSSNLYEEV--ENNK-KWTENQFLK----YRKDH--LGHINECLKVLQEKL 343
LLE K H + Y+++ EN++ T +Q LK + DH L + K+ Q +L
Sbjct: 1226 MLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRL 1285
Query: 344 EKSENKMEEKLLQLSSKVENFINTQKQETQLSKVKHMENKLSKKMEQMEKQIWGELETMQ 403
E +K++E+ QL T+L+ + ++L +E+ + + +++T+
Sbjct: 1286 EAEFSKLKEQYQQLDI----------TSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLM 1335
Query: 404 NEYQSGFKSIHDSLSSLQQIQKTKMD-LEKYKVQKDLKKLQRKIVE 448
+ ++ + +S Q+ +D L + + QK+ KL+ KI++
Sbjct: 1336 LQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKE--KLEEKIMD 1379
Score = 36.6 bits (83), Expect = 0.048
Identities = 85/413 (20%), Positives = 161/413 (38%), Gaps = 58/413 (14%)
Query: 73 QEKKVRLSPAKMSTKNSTDLVEYVDKSHAFLPIIPNTQRGQLEDRLNNQARTIAFLLEQA 132
+ +K +L K S E ++ S+ L I + +L+ L N + I LE
Sbjct: 731 ESEKEQLKKGLELLKASFKKTERLEVSYQGLDI----ENQRLQKTLENSNKKIQ-QLESE 785
Query: 133 FRIKEDISACLQGTHGFRKEESLARKLLESHIQTITSIVKKLSQNIEILEDQIRARDQAA 192
+ E + LQ K S + LE +++ +L ++ + LE + + Q A
Sbjct: 786 LQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQA 845
Query: 193 TGTNFAVHEINIKHLQGVGDLRGRVARCDSSIVKLSGDIHLFRQEH---RQIEKAIQEFV 249
+ + E N+K +G+L + LS +I ++++ +++EK +E V
Sbjct: 846 EIKDTTLEENNVK----IGNL-------EKENKTLSKEIGIYKESCVRLKELEKENKELV 894
Query: 250 PALETLSKNLDMKVMQLLGKIETASSEQTSNLKMVQGDYRHEMNLLEFKFHSLSSNLYEE 309
+D+K + L + + +T + HE+ + L +
Sbjct: 895 KRA-----TIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQST 949
Query: 310 VENNKKWTENQFLKYRKDHLGHINECLKVLQEKLEKSEN--------------------- 348
++ K E++ K L E + L+ +LE+S N
Sbjct: 950 DDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQ 1009
Query: 349 -KMEEKLLQLSSKVENFINTQKQETQ-----LSKVKH--MENKLSKKMEQMEKQI----W 396
+ EE+++Q S + N ++E+Q L KVK +E + + Q EKQ
Sbjct: 1010 RQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQL 1069
Query: 397 GELETMQNEYQSGFKSIHDSLSSLQQIQKTKMDLEKYKVQKDLKKLQRKIVEL 449
+LET N Q+ ++ SLQ+ Q T + + K+Q + L + L
Sbjct: 1070 KQLETQNNNLQAQILALQRQTVSLQE-QNTTLQTQNAKLQVENSTLNSQSTSL 1121
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 56.2 bits (134), Expect = 6e-08
Identities = 91/455 (20%), Positives = 194/455 (42%), Gaps = 31/455 (6%)
Query: 15 RKKSQRLFFKNIKSTKNKAGKASIMSSDTNVNKSASPTATAEEQPVEPDGPLPGSDNNQE 74
RKK + L +N+ T A K S M ++ + E P L G + N+
Sbjct: 402 RKKIEELMEENM--TLEMAQKQS-MDESLHLGWELEQISRTSELSEAPQKSL-GHEVNEL 457
Query: 75 KKVRLSPAKMSTKNSTDLVEYVDKSHAFLPIIPNTQRGQLEDRLNNQ--ARTIAFLLEQA 132
RL +M ++ T VE + + + + L+ NQ ++ + L +
Sbjct: 458 TSSRLLKLEMENQSLTKTVEELRTT---VDSVEGNASKILKMEKENQRLSKKVEILENEI 514
Query: 133 FRIKEDISACLQGTHGFRKEESLARKLLESHIQTITSIVKKLSQNIEILEDQI---RARD 189
+ K+ + C + KE++ K +E+ + +K L Q E L + R R
Sbjct: 515 VQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRS 574
Query: 190 QAATGTNFAVHEINIKHL-QGVGDLRGRVARCDSSIVKLSGDIHLFRQEHRQIEKAIQEF 248
Q + E K L + + + ++++ + ++ ++ ++++ + E+ E
Sbjct: 575 QISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENE- 633
Query: 249 VPALETLSKNLDMKVMQLLGKIETASSEQTSNLKMVQGDYRHEMNLLEFKFHSLSSNLYE 308
+ LE ++ L K+ L E + + N ++ + + + + L FK + E
Sbjct: 634 LHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLE 693
Query: 309 EVENNKKWTENQFLKYRKDHLGHINECLKVLQEKLEKSENKMEEKLLQLSSKVE----NF 364
+ EN++ EN L+ + L +C + +L+ ++E + QL +E +F
Sbjct: 694 K-ENSQLDEENLELRRNVESL----KCASMKMAQLQLENKELESEKEQLKKGLELLKASF 748
Query: 365 INTQKQETQLSKVKHMENKLSKKMEQMEK---QIWGELETMQNEYQSGFKSIHD---SLS 418
T++ E + +L K +E K Q+ EL+ ++ E Q+ K++ + S
Sbjct: 749 KKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSK 808
Query: 419 SLQQIQKTKMDLEK--YKVQKDLKKLQRKIVELQE 451
L+Q++K LE+ +++KD K+L+++ L++
Sbjct: 809 RLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQ 843
Score = 43.1 bits (100), Expect = 5e-04
Identities = 64/338 (18%), Positives = 139/338 (41%), Gaps = 50/338 (14%)
Query: 145 GTHGFRKEESLARKLLESHIQTITSIVKKLSQNIEILEDQIRARDQAATGTNFAVHEINI 204
G+ G ++ ES R+ L + + +++L Q +E +Q+ Q + +
Sbjct: 236 GSPGMKRTES--RQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQ 293
Query: 205 KHLQGVGDLRG----------------RVARCDSSIVKLSGDIHLFRQEHRQIEKAIQEF 248
+++ + D R RV + +S + + +H ++E+ ++
Sbjct: 294 ENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDN 353
Query: 249 VPALETLSK----------------NLDMKVMQLLGKIETASSEQTSNLKMVQGDYRHEM 292
LET + L+ + +QL K+ E+ + K ++ M
Sbjct: 354 QVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENM 413
Query: 293 NLLEFKFHSLSSNLYEEVENNKKWTENQFLKYRKDHLGH-INECLKVLQEKLEKSENKME 351
L + S+ +L+ E + ++ + + LGH +NE KLE +
Sbjct: 414 TLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLT 473
Query: 352 EKLLQLSSKVENFINTQKQETQLSKVKHMENKLSKKMEQMEKQIWGELETMQNEYQSGFK 411
+ + +L + V++ + +++ K++ +LSKK+E +E +I E +++QN
Sbjct: 474 KTVEELRTTVDS---VEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQN------- 523
Query: 412 SIHDSLSSLQQIQKTKMDLEK-YKVQKDLKKLQRKIVE 448
+LS + + K K LEK + ++ + Q KI+E
Sbjct: 524 --CQNLS--KDLMKEKAQLEKTIETLRENSERQIKILE 557
Score = 40.4 bits (93), Expect = 0.003
Identities = 89/406 (21%), Positives = 173/406 (42%), Gaps = 52/406 (12%)
Query: 56 EEQPVEPDGPLPGSDNNQEKKVRLSPAKMSTKNSTDLVEYVDKSHAFLPI---IPNTQRG 112
EE+ V+ P+ G DN E++ + + ++ K L+E V++++A L TQ
Sbjct: 1012 EERMVQSSPPISGEDNKWERESQETTREL-LKVKDRLIE-VERNNATLQAEKQALKTQLK 1069
Query: 113 QLEDRLNNQARTIAFLLEQAFRIKEDISACLQGTHGFRKEESLARKLLESHIQTITSIVK 172
QLE + NN I L Q ++E + + E S S + ++
Sbjct: 1070 QLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLI 1129
Query: 173 KLSQNIEILEDQIRARDQAATGTNFAVHEINIKHLQGVGDLRGRVARCDSSIVKLSGDIH 232
+ S E I+ R+ ++++ IK + + L R A S++ G +
Sbjct: 1130 QQSSLENENESVIKEREDLK-----SLYDSLIKDHEKLELLHERQASEYESLISKHGTL- 1183
Query: 233 LFRQEHRQIEKAIQEFVPALETLSKNLDMKVMQLLGKIETASSEQTSNLKMVQGDYRHEM 292
+ H+ LE ++L+ + QLL K + + LK+ Q E
Sbjct: 1184 --KSAHKN-----------LEVEHRDLEDRYNQLL-KQKGQLEDLEKMLKVEQ-----EK 1224
Query: 293 NLLEFKFHSLSSNLYEEV--ENNK-KWTENQFLK----YRKDH--LGHINECLKVLQEKL 343
LLE K H + Y+++ EN++ T +Q LK + DH L + K+ Q +L
Sbjct: 1225 MLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRL 1284
Query: 344 EKSENKMEEKLLQLSSKVENFINTQKQETQLSKVKHMENKLSKKMEQMEKQIWGELETMQ 403
E +K++E+ QL T+L+ + ++L +E+ + + +++T+
Sbjct: 1285 EAEFSKLKEQYQQLDI----------TSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLM 1334
Query: 404 NEYQSGFKSIHDSLSSLQQIQKTKMD-LEKYKVQKDLKKLQRKIVE 448
+ ++ + +S Q+ +D L + + QK+ KL+ KI++
Sbjct: 1335 LQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKE--KLEEKIMD 1378
Score = 35.4 bits (80), Expect = 0.11
Identities = 77/398 (19%), Positives = 164/398 (41%), Gaps = 53/398 (13%)
Query: 73 QEKKVRLSPAKMSTKNSTDLVEYVDKSHAFLPIIPNTQRGQLEDRLNNQARTIAFLLEQA 132
+ +K +L K S E ++ S+ L I + +L+ L N + I LE
Sbjct: 731 ESEKEQLKKGLELLKASFKKTERLEVSYQGLDI----ENQRLQKTLENSNKKIQ-QLESE 785
Query: 133 FRIKEDISACLQGTHGFRKEESLARKLLESHIQTITSIVKKLSQNIEILEDQIRARDQAA 192
+ E + LQ K S + LE +++ +L ++ + LE + + Q A
Sbjct: 786 LQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQA 845
Query: 193 TGTNFAVHEINIKHLQGVGDLRGRVARCDSSIVKLSGDIHLFRQEH---RQIEKAIQEFV 249
+ + E N+K +G+L + LS +I ++++ +++EK +E V
Sbjct: 846 EIKDTTLEENNVK----IGNL-------EKENKTLSKEIGIYKESCVRLKELEKENKELV 894
Query: 250 PALETLSKNLDMKVMQLLGKIETASSEQTSNLKMVQGDYRHEMNLLEFKFHSLSSNLYEE 309
K + + L+ E SE+ +M +++ L + + N E
Sbjct: 895 -------KRATIDIKTLVTLREDLVSEKLKTQQM-----NNDLEKLTHELEKIGLNK-ER 941
Query: 310 VENNKKWTENQFLKYRKDHLGHINECLKVLQEKLEKSENKMEEKLLQLSSKVENFINTQK 369
+ ++++ T++++ + + L++ +EK+ E ++EE + ++ + T K
Sbjct: 942 LLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEEST-NYNQQLRQELKTVK 1000
Query: 370 QETQLSKVKHMENKLSKKMEQMEKQIWGELETMQNEYQSGFKSI-------------HDS 416
+ + K + E ++M Q I GE + E Q + + + +
Sbjct: 1001 KNYEALKQRQDE----ERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNAT 1056
Query: 417 LSSLQQIQKTKM---DLEKYKVQKDLKKLQRKIVELQE 451
L + +Q KT++ + + +Q + LQR+ V LQE
Sbjct: 1057 LQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQE 1094
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 56.2 bits (134), Expect = 6e-08
Identities = 60/292 (20%), Positives = 135/292 (46%), Gaps = 36/292 (12%)
Query: 171 VKKLSQNIEILEDQIRARDQAATGTNFAVHEINIKHLQGVGDLRGRVARCDSSIVKLSGD 230
+K+ + I+ L + + + + N K + + +L+ + ++ L D
Sbjct: 1783 LKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKAN----EHQLITLKKD 1838
Query: 231 IHLFRQEHRQIEKAIQEFVPALETLSK------NLDMKVMQLLGKIETASSEQTSNLKMV 284
++ +++ ++E+ ++ TLSK NL K+ + L ++++ E+ NL+ V
Sbjct: 1839 VNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKER-DNLRRV 1897
Query: 285 QGDYRHEMNLLEFKFHSLSSNLYEEVENNKKWTENQFLKYRKDHLGHINECLKV------ 338
+ + E + L+ + E + K T K K+ + + E +
Sbjct: 1898 EETLKLERDQLKESLQETKARDLEIQQELK--TARMLSKEHKETVDKLREKISEKTIQIS 1955
Query: 339 -LQEKLEKSENKMEEKLLQLSSKVENFINTQKQETQLSKVK---HMENKLSKKMEQMEKQ 394
+Q+ L+KS++++++K+ +L QK+E QL +VK +M +K +MEQ++KQ
Sbjct: 1956 DIQKDLDKSKDELQKKIQEL----------QKKELQLLRVKEDVNMSHKKINEMEQLKKQ 2005
Query: 395 IWGELETMQNEYQSGF---KSIHDSLSSLQQIQKTKMDLEKYKVQKDLKKLQ 443
+ +MQ+ F K +H+SL ++ + K + +L + K +++ Q
Sbjct: 2006 FEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKESLKMERDQ 2057
Score = 54.3 bits (129), Expect = 2e-07
Identities = 76/359 (21%), Positives = 151/359 (42%), Gaps = 63/359 (17%)
Query: 135 IKEDISACLQGTHGFRKEESLARKLLESHIQTITSIVKK------LSQNIEILEDQIR-- 186
+KE E ++L +++ + S+ K+ + + +++ DQ++
Sbjct: 1649 LKEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKEN 1708
Query: 187 -----ARDQAATGTNFAVHEINIKHLQGVGDLRGRVARCDSSIVKLSGDIHLFRQEHRQI 241
RD VH +H + + LRG V+ + I + D+ +
Sbjct: 1709 LRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQ 1768
Query: 242 EKAIQEFVPALETLSKNLDMKVMQ-LLGKIETASSEQTSNLKMVQGDYRHEMNLLEFKFH 300
+ IQE E ++ +K Q + K+ SE+T L +Q D + L+ K
Sbjct: 1769 DLKIQE-----ELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQ 1823
Query: 301 SLSSNLYEEVENNKKWTENQFLKYRKDHLGHINECLKVLQEKLEKSENKMEEKLLQLSS- 359
L +N E+Q + +KD +NE K + E +E+ + +++++ L LS
Sbjct: 1824 ELKAN------------EHQLITLKKD----VNETQKKVSE-MEQLKKQIKDQSLTLSKL 1866
Query: 360 KVENFINTQKQETQLSKVK----------HMENKLSKKMEQMEK----------QIWGEL 399
++EN QK L ++K +E L + +Q+++ +I EL
Sbjct: 1867 EIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQEL 1926
Query: 400 ET---MQNEYQSGFKSIHDSLSSLQ-QIQKTKMDLEKYK--VQKDLKKLQRKIVELQEV 452
+T + E++ + + +S QI + DL+K K +QK +++LQ+K ++L V
Sbjct: 1927 KTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRV 1985
Score = 53.5 bits (127), Expect = 4e-07
Identities = 69/312 (22%), Positives = 140/312 (44%), Gaps = 44/312 (14%)
Query: 155 LARKLLESH--IQTITS---IVKKLSQNIEILEDQIRA--RDQAATGTN----FAVHEIN 203
LA+KL E++ +++IT ++K+L ++ E D +R R+ ATG + I+
Sbjct: 1184 LAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIH 1243
Query: 204 IK-HLQGVGDLRGRVARCDSSIVKLSG--DIHLFRQEHRQIEKAIQEFVPALETLSKNLD 260
+K H + + +LR V+ + I+ H QE + QE +P ++ +S+ +
Sbjct: 1244 LKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQE 1303
Query: 261 -MKVMQLLGKIETASSEQTSNLKMVQGDYRHEMNLLEFKFHSLSSNLYEEVENNKKWTEN 319
M ++LL + T T R EM L L+ E E K T+
Sbjct: 1304 TMNELELLTEQSTTKDSTTLA--------RIEMERLR-----LNEKFQESQEEIKSLTKE 1350
Query: 320 QFLKYRKDHLGHINECLKVLQEKLEKSENKMEEKLLQLSSKVENFINTQKQETQLSKVKH 379
+ + LK ++E LE ++++E + + +K++ + Q+Q + + +
Sbjct: 1351 R-------------DNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDN 1397
Query: 380 MENKLSKKMEQMEKQIWGELETMQNEYQSGFKSIHDSLSSLQQIQKTKMDLEKYK--VQK 437
K+ +MEQ + + L ++ E K + +S ++ + K K DL++ + +Q
Sbjct: 1398 ETTKIVSEMEQFKPKD-SALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQS 1456
Query: 438 DLKKLQRKIVEL 449
+ +L+ I E+
Sbjct: 1457 ESDQLKENIKEI 1468
Score = 49.7 bits (117), Expect = 5e-06
Identities = 73/392 (18%), Positives = 165/392 (42%), Gaps = 43/392 (10%)
Query: 70 DNNQEKKVRLSPAKMSTKNSTDLVEYVDKSHAFLPIIPNTQRGQLEDRLNNQARTIAFLL 129
D Q+ K+ L + + +L + K + L + T+ L + R + L
Sbjct: 828 DFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGAL-KTELSYKTQELQEKTREVQERL 886
Query: 130 EQAFRIKEDISACLQGTHGFRKEESLARKLLESHIQTITSI------VKKLSQNIEILED 183
+ ++KE + +E++L + L+ ++ + ++ +K+L ++++I D
Sbjct: 887 NEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERD 946
Query: 184 QIRARDQAATGTNFAVHEINIKHLQGVGDLRGRVARCDSSIVK-LSGDIHL--------- 233
Q+++ N E L+ + + + S I + +S ++H+
Sbjct: 947 QLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKD 1006
Query: 234 -FRQEHRQIEKAIQEFVPALETLSKNL-DMKVMQLLGKIETASSEQTSNLKMVQGDYRHE 291
F+Q+ I+K +TL+ ++ D ++++ KI + E+ +M++ +
Sbjct: 1007 EFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEK 1066
Query: 292 MNLLEFKFHSLSSNLYEEVENNKKWT--------ENQFLKYRKDH-------LGHINECL 336
L L N+ +EN ++ + + + K+H L + L
Sbjct: 1067 EQLKT----DLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRL 1122
Query: 337 KVLQEKLEKSENKMEEKLLQLSSKVENFINTQKQETQLSKVKHMENKLSKKMEQMEKQIW 396
++EKL++ +++EK QL + E QK +++++++++N+L K +E
Sbjct: 1123 AEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQK---KINEIENLKNELKNKELTLEHMET 1179
Query: 397 GELETMQ--NEYQSGFKSIHDSLSSLQQIQKT 426
LE Q NE KSI L+++QK+
Sbjct: 1180 ERLELAQKLNENYEEVKSITKERKVLKELQKS 1211
Score = 33.5 bits (75), Expect = 0.41
Identities = 62/337 (18%), Positives = 146/337 (43%), Gaps = 62/337 (18%)
Query: 129 LEQAFRIKED-ISACLQGTHG----FRKEESLARKLLESHIQTITSIVKKLSQNIEILED 183
+E+ +++ D + LQ T ++E AR L + H +T+ + +K+S+ + D
Sbjct: 1897 VEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISD 1956
Query: 184 QIRARDQAATGTNFAVHEINIKHLQGVGDLRGRVARCDSSIVKLSGDIHLFRQEHRQIEK 243
+ D++ + E+ K LQ ++++ D+++ ++ ++E+
Sbjct: 1957 IQKDLDKSKDELQKKIQELQKKELQ---------------LLRVKEDVNMSHKKINEMEQ 2001
Query: 244 AIQEFVPALETLSKNLDMKVMQLLGKIETASSEQTSNLKMVQGDYRHEMNLLEFKFHSLS 303
++F ++NL M+ S + N ++ + HE +L E + +
Sbjct: 2002 LKKQFE------AQNLSMQ------------SVRMDNFQLTK--KLHE-SLEEIRIVAKE 2040
Query: 304 SNLYEEVENNKKWTENQFLKYRKDHLGHINECLKVLQEK--LEKSENKMEEKLLQLSSKV 361
+ ++ + K +QF+ ++ + + +V EK L + + E L + S++
Sbjct: 2041 RDELRRIKESLKMERDQFIATLREMIARDRQNHQVKPEKRLLSDGQQHLTESLREKCSRI 2100
Query: 362 ENFINTQKQETQLSKVKHMENKLSKKMEQMEKQIWGELETMQNEYQSGFKSIHDSLSSLQ 421
+ + K+ +++ N+LS +E+ E+E Q E K+ + SL LQ
Sbjct: 2101 KELL---KRYSEMDDHYECLNRLSLDLEK-------EIE-FQKELSMRVKA-NLSLPYLQ 2148
Query: 422 --QIQK-----TKMDLEKYKVQKDLKKLQRKIVELQE 451
I+K + +E +++ K LK + + +++E
Sbjct: 2149 TKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKE 2185
Score = 32.7 bits (73), Expect = 0.69
Identities = 78/403 (19%), Positives = 164/403 (40%), Gaps = 69/403 (17%)
Query: 74 EKKVRLSPAKMSTKNSTDLVEYVDKSHAFLPI-IPNTQRG--QLEDRLNNQARTIAFLLE 130
E + L A+M +K + V+ + + + I I + Q+ + +D L + + +
Sbjct: 1921 EIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKEL 1980
Query: 131 QAFRIKEDISACLQGTHGFRKEESLARKLLESHIQTITSI-------VKKLSQNIEILED 183
Q R+KED++ +H E +K E+ ++ S+ KKL +++E +
Sbjct: 1981 QLLRVKEDVNM----SHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRI 2036
Query: 184 QIRARDQAATGTNFAVHEINIKHLQGVGDLRGRVARCDSSIVKLSGDIHLFRQEHRQIEK 243
+ RD+ + ++ Q + LR +AR + H + E R +
Sbjct: 2037 VAKERDELRR----IKESLKMERDQFIATLREMIARDRQN--------HQVKPEKRLLSD 2084
Query: 244 AIQEFVPALETLSKNLDMKVMQLLGKIETASSEQTSNLKMVQGDYRHEMNLLEFKFHSLS 303
Q +L ++ +LL K + + L + D E+ + +
Sbjct: 2085 GQQHLTESLREKCS----RIKELL-KRYSEMDDHYECLNRLSLDLEKEIEFQKELSMRVK 2139
Query: 304 SNL---YEEVENNKK-WTENQ-----FLKYRKDHLGHINECLKVLQEKLEKSENKMEEKL 354
+NL Y + ++ +K +T NQ F + K L ++ + ++E+ +S NK E
Sbjct: 2140 ANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKK-LKYVLSYVTKIKEEQHESINKFEMDF 2198
Query: 355 LQLSSKVENFINTQKQETQLSKVKHMEN------------KLSKKMEQMEKQIW-----G 397
+ +KQ+ L K++H++ KL++ M+ ++I
Sbjct: 2199 ID---------EVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIEEILKDFSES 2249
Query: 398 ELETMQNEYQSGFKSIHDSLSSLQQIQKTKMDLEKYK--VQKD 438
E +++ E+Q + + L++ T+ D+EK K +QK+
Sbjct: 2250 EFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKE 2292
>gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens]
Length = 1979
Score = 53.9 bits (128), Expect = 3e-07
Identities = 82/380 (21%), Positives = 161/380 (42%), Gaps = 50/380 (13%)
Query: 113 QLEDRLNNQARTIAFLLEQAFRIKEDISACLQGTHGFRKEESLARKLLESHIQTITSIVK 172
+L L + TI L E R+ + I+A + ++ K L+ + ++K
Sbjct: 1351 ELRKSLQEKDATIRTLQENNHRLSDSIAATSELERKEHEQTDSEIKQLKEKQDVLQKLLK 1410
Query: 173 KLSQNIEILEDQIRARDQAATGTNFAVHEINIKHL--QGVGDLRGRVARCDSSIVKLSGD 230
+ I+ DQ+ + ++ T +++N L Q V +L+ R+ + I KL G+
Sbjct: 1411 EKDLLIKAKSDQLLSSNENFT------NKVNENELLRQAVTNLKERILILEMDIGKLKGE 1464
Query: 231 ----IHLFR---QEHRQIEKAIQEFVPALETLS------KNLDMKVMQLLGKIETASSEQ 277
+ +R E++ +++ +F L K + QLL + E + +
Sbjct: 1465 NEKIVETYRGKETEYQALQETNMKFSMMLREKEFECHSMKEKALAFEQLLKEKEQGKTGE 1524
Query: 278 TSNL---------KMVQGDYRHEMNLLEFKFHSLSSN-LYEEVEN--NKKWTENQFLKYR 325
+ L K V + +L K + + L EV+ +K++ NQ L+
Sbjct: 1525 LNQLLNAVKSMQEKTVVFQQERDQVMLALKQKQMENTALQNEVQRLRDKEFRSNQELERL 1584
Query: 326 KDHL-----GHINECLKV--LQEKLEKSENKMEEKLLQLSSKVENFINTQKQETQLSKVK 378
++HL + E L + KL K +EEKL+ S+ +EN + + Q+ ++
Sbjct: 1585 RNHLLESEDSYTREALAAEDREAKLRKKVTVLEEKLVSSSNAMEN--ASHQASVQVESLQ 1642
Query: 379 HMENKLSKKMEQMEKQIWGELETMQNEYQSGFKSIHDSLSSLQQIQKT--KMDLEKYKV- 435
N +SK+ ++ Q+ E ++ +Y ++ L QQ +K +LEK K
Sbjct: 1643 EQLNVVSKQRDETALQLSVSQEQVK-QYALSLANLQMVLEHFQQEEKAMYSAELEKQKQL 1701
Query: 436 ----QKDLKKLQRKIVELQE 451
+K+ + L+ K++ LQE
Sbjct: 1702 IAEWKKNAENLEGKVISLQE 1721
Score = 45.8 bits (107), Expect = 8e-05
Identities = 61/333 (18%), Positives = 142/333 (42%), Gaps = 47/333 (14%)
Query: 129 LEQAFRIKEDISAC---LQGTHGFRKEESLARKLLESHIQTITSIVKKLSQNIEILEDQI 185
+E+ FR+++ +S + ++ SLA L KL IE+LE +
Sbjct: 384 VEEVFRLQQALSDAENEIMRLSSLNQDNSLAEDNL------------KLKMRIEVLEKEK 431
Query: 186 RARDQAATGTNFAVHEINIKHLQGVGDLRGRVARCDSSIVKLSGDIHLFRQEHRQIEKAI 245
Q ++ ++N ++ ++ A D + L ++H R E+ +
Sbjct: 432 SLLSQEKEELQMSLLKLNNEY-----EVIKSTATRD---ISLDSELHDLRLNLEAKEQEL 483
Query: 246 QEFVPALETLSKNLDMKVMQLLGKIETASSEQTSNLKMVQGDYRHEMNLLEFKFHSLSSN 305
+ + ETL ++ +++ + E T ++ +++ + N + L +
Sbjct: 484 NQSISEKETLIAEIE--------ELDRQNQEATKHMILIKDQLSKQQNEGDSIISKLKQD 535
Query: 306 LYEEVENNKKWTENQF-----LKYRKDHLGHINECLKVLQEKLEKSENKMEEKLLQLSSK 360
L +E + + +++ L +K+ L L L +K E+K+E + QL+
Sbjct: 536 LNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDLHLTKQKLEDKVENLVDQLNKS 595
Query: 361 VENFINTQKQETQLSK-VKHMENKLSKKMEQMEKQIWGE-----LETMQNEYQSGFKSIH 414
E+ ++ QK+ +L + ++ E +LS+ ++ + + + +T+ E ++ +++
Sbjct: 596 QESNVSIQKENLELKEHIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRNLK 655
Query: 415 DSLSSLQQIQKTKMDLEKYKVQKDLKKLQRKIV 447
+LS L+Q+ + KV D+K K+V
Sbjct: 656 QNLSELEQLNENLK-----KVAFDVKMENEKLV 683
Score = 39.3 bits (90), Expect = 0.007
Identities = 67/372 (18%), Positives = 158/372 (42%), Gaps = 45/372 (12%)
Query: 72 NQEKKVRLSPAKMSTKN-STDLVEYVDKSHAFLPIIPNTQRGQLEDRLNNQARTIAFLLE 130
NQ+K + ++ K + + TD E D + L ++ QL +N + I L E
Sbjct: 768 NQKKDMEIAELKKNIEQMDTDHKETKDVLSSSLE-----EQKQLTQLINKKEIFIEKLKE 822
Query: 131 QAFRIKEDISACLQGTHGFRKEESLARKLLESHIQTITSIVKKLSQNIEILEDQIRARDQ 190
++ +++E++ Q RK E L R+ +E +++ S+ + +N + E+ R R++
Sbjct: 823 RSSKLQEELDKYSQA---LRKNEIL-RQTIEEKDRSLGSMKE---ENNHLQEELERLREE 875
Query: 191 AATGTNFAVHEINIKHLQGVGDLRGRVARCDSSIVKLSGDIHLFRQEHRQIEKAIQEFVP 250
+ A + K L V +L V++ ++ I++ ++E +
Sbjct: 876 QSRTAPVA----DPKTLDSVTELASEVSQLNT------------------IKEHLEEEIK 913
Query: 251 ALETLSKNLDMKVMQLLGKIETASSEQTSNLKMVQGDYRHE-MNLLEFKFHSLSSNLYEE 309
+ + ++ + MQLL ++ E M + Y+HE MN + +
Sbjct: 914 HHQKIIEDQNQSKMQLLQSLQEQKKE------MDEFRYQHEQMNATHTQLFLEKDEEIKS 967
Query: 310 VENNKKWTENQFLKYRKDHLGHINECLKVLQEKLEKSENKMEEKLLQLSSKVENFINTQK 369
++ + + Q + R+D ++ + + + EN E+ L + ++
Sbjct: 968 LQKTIEQIKTQLHEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKAETERLVKGIKE 1027
Query: 370 QETQLSKVKHMENKLSKKMEQMEKQIWGELETMQNEYQSGFKSIHDSLSS---LQQIQKT 426
+E ++ + L+K+++Q+ K G+L + + +++H +SS Q +
Sbjct: 1028 RELEIKLLNEKNISLTKQIDQLSKDEVGKLTQIIQQKDLEIQALHARISSTSHTQDVVYL 1087
Query: 427 KMDLEKYKVQKD 438
+ L+ Y ++++
Sbjct: 1088 QQQLQAYAMERE 1099
Score = 32.3 bits (72), Expect = 0.90
Identities = 48/251 (19%), Positives = 107/251 (42%), Gaps = 32/251 (12%)
Query: 224 IVKLSGDIHLFRQEHRQIEKAIQEFVPALETL-SKNLDMKVMQLLGKIETASSEQTSNLK 282
I+ +I+ E ++E + + +T ++ D + K++ E N
Sbjct: 167 IISSQQEINRLSNEVSRLESEVGHWRHIAQTSKAQGTDNSDQSEICKLQNIIKELKQNRS 226
Query: 283 MVQGDYRHEMNLLEF----KFHSLSSNLYEEVENNKKWTENQFLKYRKDHLGHINECLKV 338
D++HEM++L+ K +S EE+ + ++ E ++ G I L
Sbjct: 227 QEIDDHQHEMSVLQNAHQQKLTEISRRHREELSDYEERIEELENLLQQGGSGVIETDLSK 286
Query: 339 LQEKLEKSENKMEEKLLQLSSKVENFINTQKQETQLSKVKHMENKLS----------KKM 388
+ E +K +Q+ ++E +T+K E K+K + KLS ++
Sbjct: 287 IYEM---------QKTIQVL-QIEKVESTKKMEQLEDKIKDINKKLSSAENDRDILRREQ 336
Query: 389 EQM---EKQIWGELETMQ---NEYQSGFKSIHDSLSSLQQIQKTKMDLEK-YKVQKDLKK 441
EQ+ ++QI E E ++ ++ Q D+++ ++I +E+ +++Q+ L
Sbjct: 337 EQLNVEKRQIMEECENLKLECSKLQPSAVKQSDTMTEKERILAQSASVEEVFRLQQALSD 396
Query: 442 LQRKIVELQEV 452
+ +I+ L +
Sbjct: 397 AENEIMRLSSL 407
Score = 31.2 bits (69), Expect = 2.0
Identities = 55/282 (19%), Positives = 122/282 (43%), Gaps = 57/282 (20%)
Query: 158 KLLESHI--QTITSIVKKLSQNIEILEDQIRARDQAATGTNFAVHEINIKHLQGVGDLRG 215
KL++S + + +KL +E L DQ+ ++ N ++ + N++ + +
Sbjct: 563 KLIQSEVALNDLHLTKQKLEDKVENLVDQLNKSQES----NVSIQKENLELKEHIRQNEE 618
Query: 216 RVARCDSSIVK-LSGDIH------LFRQEHRQIEKAIQEFVPALETLSKNL-----DMKV 263
++R + +++ L+ D + L ++ ++ +++ + LE L++NL D+K+
Sbjct: 619 ELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRN-LKQNLSELEQLNENLKKVAFDVKM 677
Query: 264 MQ-----------------LLGKIETASSEQT--SNLKMVQGDYRHEM-----NLLEFKF 299
L G + + + T LKM +G+ E+ LLE
Sbjct: 678 ENEKLVLACEDVRHQLEECLAGNNQLSLEKNTIVETLKMEKGEIEAELCWAKKRLLE--- 734
Query: 300 HSLSSNLYE---EVENNKKWTENQFLKYRKDHLGHINECLKVLQEKLEKSENKMEEKLLQ 356
+N YE E +N + L+ +HL +N+ + +L+K+ +M+ +
Sbjct: 735 ---EANKYEKTIEELSNARNLNTSALQLEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKE 791
Query: 357 LSSKVENFINTQKQETQLSK-----VKHMENKLSKKMEQMEK 393
+ + + QKQ TQL ++ ++ + SK E+++K
Sbjct: 792 TKDVLSSSLEEQKQLTQLINKKEIFIEKLKERSSKLQEELDK 833
Score = 30.0 bits (66), Expect = 4.5
Identities = 83/475 (17%), Positives = 188/475 (39%), Gaps = 43/475 (9%)
Query: 2 QLQFLGTLASSEKRKKSQRLFFKNIKSTKNKAGKASIMSSDTNVNKSASPTATAEEQPVE 61
++Q L SEK S+ + +K K + + +++ K+ S T ++ +
Sbjct: 998 KVQSLNIENGSEKHDLSKAETERLVKGIKERELEIKLLNE-----KNISLTKQIDQLSKD 1052
Query: 62 PDGPLPGSDNNQEKKVRLSPAKMSTKNSTDLVEYVDKSHAFLPIIPNTQRGQLEDRLNNQ 121
G L ++ +++ A++S+ + T V Y+ + + +R ++ LN +
Sbjct: 1053 EVGKLTQIIQQKDLEIQALHARISSTSHTQDVVYLQQQLQAYAM----EREKVFAVLNEK 1108
Query: 122 ARTIAFLLEQAFRIKEDISACLQGTHGFRKE--------ESLARKLLESHIQTITSIVKK 173
R + L + ++ + ++A + E ES + + IQ ++ I+++
Sbjct: 1109 TRENSHLKTEYHKMMDIVAAKEAALIKLQDENKKLSTRFESSGQDMFRETIQNLSRIIRE 1168
Query: 174 LSQNIEILED---------QIRARDQAATGTNFAVHEINIKHLQGVGDLRGRVARCDSSI 224
I+ L Q + A G N E + LQ L+ +V + +
Sbjct: 1169 KDIEIDALSQKCQTLLAVLQTSSTGNEAGGVNSNQFE---ELLQERDKLKQQVKKMEEWK 1225
Query: 225 VKLSGDIHLFRQEHRQIEKAIQEFVPALETLSKNLDMKVMQLLGKIETASSEQTS----- 279
++ + + E Q+++ + + + S N + G I++ +T
Sbjct: 1226 QQVMTTVQNMQHESAQLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFG 1285
Query: 280 -NLKMVQ---GDYRHEMNLLEFKFHSLSSNLYEEVENNKKWTENQFLKYRKDHLGHINEC 335
L VQ G + +LL K +S L + E L+ K + ++E
Sbjct: 1286 QELAQVQHSIGQLCNTKDLLLGKLDIISPQLSSASLLTPQSAE--CLRASKSEV--LSES 1341
Query: 336 LKVLQEKLEKSENKMEEKLLQLSSKVENFINTQKQETQLSKVKHMENKLSKKMEQMEKQI 395
++LQ++LE+ ++EK + + EN S+++ E++ + + K+
Sbjct: 1342 SELLQQELEELRKSLQEKDATIRTLQENNHRLSDSIAATSELERKEHEQTDSEIKQLKEK 1401
Query: 396 WGELETMQNEYQSGFKSIHDSLSSLQQIQKTKMDLEKYKVQKDLKKLQRKIVELQ 450
L+ + E K+ D L S + K++ E +++ + L+ +I+ L+
Sbjct: 1402 QDVLQKLLKEKDLLIKAKSDQLLSSNENFTNKVN-ENELLRQAVTNLKERILILE 1455
>gi|237858621 polyamine modulated factor 1 binding protein 1 isoform
b [Homo sapiens]
Length = 882
Score = 53.5 bits (127), Expect = 4e-07
Identities = 76/368 (20%), Positives = 151/368 (41%), Gaps = 66/368 (17%)
Query: 113 QLEDRLNNQARTIAFLLEQAFRIKEDISACLQGTHGFRKEESLARKLLESHIQTITSIVK 172
+L++ L + +QA + KE+ A L G H + L + LL + T ++
Sbjct: 322 KLKNSLEEAKQQERLAAQQAAQCKEE--AALAGCHLEDTQRKLQKGLLLDKQKADT--IQ 377
Query: 173 KLSQNIEILEDQIRARDQAATGTNFAVHEINIKHLQGVGDLRGRVARCDSSIVKLSGDIH 232
+L + +++L+ + ++ T V E++++ + + L
Sbjct: 378 ELQRELQMLQKESSMAEKEQTSNRKRVEELSLELSEALRKLENS---------------- 421
Query: 233 LFRQEHRQIEKAIQEFVPALETLSKNLDMKVMQLLGKIETASSEQTSNLKMVQGDYRHEM 292
+E RQ++K + E DMK+ +L +I+ EQ S ++ D +
Sbjct: 422 --DKEKRQLQKTVAE-----------QDMKMNDMLDRIKHQHREQGSIKCKLEEDLQEAT 468
Query: 293 NLLEFKFHSLSSNLYEE---------------------VENNKKW-TENQFLKYR----- 325
LLE K L + E EN++K EN+ L+
Sbjct: 469 KLLEDKREQLKKSKEHEKLMEGELEALRQEFKKKDKTLKENSRKLEEENENLRAELQCCS 528
Query: 326 ---KDHLGHINECLKVLQEKLEKSENKMEEKLLQLSSKVENFINTQKQETQLSKVKHMEN 382
+ L N +V+Q+ L K +E L+ L ++++ + +K Q + K +
Sbjct: 529 TQLESSLNKYNTSQQVIQD-LNKEIALQKESLMSLQAQLDKALQKEKHYLQTTITKEAYD 587
Query: 383 KLSKKMEQMEKQIWGELETMQNEYQSGFKSIHDSLSSLQQIQKTKMDLEKYKVQKDLKKL 442
LS+K + + LE + N S KS+ SL+ Q+ +K +++ E ++ +KKL
Sbjct: 588 ALSRKSAACQDDLTQALEKL-NHVTSETKSLQQSLTQTQE-KKAQLEEEIIAYEERMKKL 645
Query: 443 QRKIVELQ 450
++ +L+
Sbjct: 646 NTELRKLR 653
Score = 53.1 bits (126), Expect = 5e-07
Identities = 68/341 (19%), Positives = 148/341 (43%), Gaps = 63/341 (18%)
Query: 150 RKEESLARKLLESHIQTITSIVKKLSQNIEILEDQIRARDQAATGTNFAVHEIN-----I 204
+KE S+A K S+ + + + +LS+ + LE+ + + Q ++N I
Sbjct: 387 QKESSMAEKEQTSNRKRVEELSLELSEALRKLENSDKEKRQLQKTVAEQDMKMNDMLDRI 446
Query: 205 KHL---QG----------------VGDLRGRVARCDSSIVKLSGDIHLFRQEHRQIEKAI 245
KH QG + D R ++ + + G++ RQE ++ +K +
Sbjct: 447 KHQHREQGSIKCKLEEDLQEATKLLEDKREQLKKSKEHEKLMEGELEALRQEFKKKDKTL 506
Query: 246 QEFVPALETLSKNLDMKVMQLLGKIETASSEQTSNLKMVQGDYRHEMNLLEFKFHSLSSN 305
+E LE ++NL ++ ++E++ ++ ++ +++Q D E+ L + SL +
Sbjct: 507 KENSRKLEEENENLRAELQCCSTQLESSLNKYNTSQQVIQ-DLNKEIALQKESLMSLQAQ 565
Query: 306 LYEEVENNKKWTENQFLKYRKD------------------HLGHINECLKVLQEKLEKSE 347
L + ++ K + + K D L H+ K LQ+ L +++
Sbjct: 566 LDKALQKEKHYLQTTITKEAYDALSRKSAACQDDLTQALEKLNHVTSETKSLQQSLTQTQ 625
Query: 348 NK---MEEKLLQLSSKVENFINTQKQETQLSKVK--HMENKL-----SKKMEQMEKQIWG 397
K +EE+++ ++ +K T+L K++ H E++L KK+E+M Q+
Sbjct: 626 EKKAQLEEEIIAYEERM------KKLNTELRKLRGFHQESELEVHAFDKKLEEMSCQVL- 678
Query: 398 ELETMQNEYQSGFKSIHDSLSSLQQIQKTKMDLEKYKVQKD 438
Q ++Q+ K + L++ Q+ L++ ++ D
Sbjct: 679 ---QWQKQHQNDLKMLAAKEEQLREFQEEMAALKENLLEDD 716
Score = 33.5 bits (75), Expect = 0.41
Identities = 67/314 (21%), Positives = 134/314 (42%), Gaps = 53/314 (16%)
Query: 145 GTHGFRKEESLARKLLESHIQTITSIVKKLSQNIEILEDQIRARDQAATGTNFAVHEINI 204
G H E L L + + + L +++ + D+ ++ + +N + E +
Sbjct: 2 GNHNENTGEKL--HLAQEQLALAGDKIASLERSLNLYRDKYQS-----SLSNIELLECQV 54
Query: 205 KHLQG-VGDLRGRVA--RCDSSIVKLSGDIHLFRQEHRQIEKAIQEFVPALETLSKNLDM 261
K LQG +G + G+ + D S V++ + QEH++ +K + E + +S+ D+
Sbjct: 55 KMLQGELGGIMGQEPENKGDHSKVRIYTSPCMI-QEHQETQKRLSE---VWQKVSQQDDL 110
Query: 262 KVMQLLGKIETASS---EQTSNLKMVQGDYRHEMNLLEFKFHSLSSNLYEEVENNKKWTE 318
+ +L K+ +++ E+ L +Q D+ H + EE E+ KK +
Sbjct: 111 -IQELRNKLACSNALVLEREKALIKLQADFASCTAT-----HRYPPSSSEECEDIKKILK 164
Query: 319 NQFLKYRKDHLGHINECLKVLQEKLEKSENKMEEKLLQLSSKVENFINTQKQETQLSKVK 378
+ L+ +KD ++CL V E+ +N +++ ++L + V
Sbjct: 165 H--LQEQKD-----SQCLHV-----EEYQNLVKDLRVELEA-----------------VS 195
Query: 379 HMENKLSKKMEQMEKQIWGELETMQNEYQSGFKSIHDSLSSLQQIQKTKMDLEKYKVQKD 438
+ + K M ++E + G E + K I LQ++Q + +K ++KD
Sbjct: 196 EQKRNIMKDMMKLELDLHGLREETSAHIERKDKDITILQCRLQELQLEFTETQKLTLKKD 255
Query: 439 LKKLQRKIVELQEV 452
K LQ K LQE+
Sbjct: 256 -KFLQEKDEMLQEL 268
>gi|237858619 polyamine modulated factor 1 binding protein 1 isoform
a [Homo sapiens]
Length = 1007
Score = 53.5 bits (127), Expect = 4e-07
Identities = 76/368 (20%), Positives = 151/368 (41%), Gaps = 66/368 (17%)
Query: 113 QLEDRLNNQARTIAFLLEQAFRIKEDISACLQGTHGFRKEESLARKLLESHIQTITSIVK 172
+L++ L + +QA + KE+ A L G H + L + LL + T ++
Sbjct: 467 KLKNSLEEAKQQERLAAQQAAQCKEE--AALAGCHLEDTQRKLQKGLLLDKQKADT--IQ 522
Query: 173 KLSQNIEILEDQIRARDQAATGTNFAVHEINIKHLQGVGDLRGRVARCDSSIVKLSGDIH 232
+L + +++L+ + ++ T V E++++ + + L
Sbjct: 523 ELQRELQMLQKESSMAEKEQTSNRKRVEELSLELSEALRKLENS---------------- 566
Query: 233 LFRQEHRQIEKAIQEFVPALETLSKNLDMKVMQLLGKIETASSEQTSNLKMVQGDYRHEM 292
+E RQ++K + E DMK+ +L +I+ EQ S ++ D +
Sbjct: 567 --DKEKRQLQKTVAE-----------QDMKMNDMLDRIKHQHREQGSIKCKLEEDLQEAT 613
Query: 293 NLLEFKFHSLSSNLYEE---------------------VENNKKW-TENQFLKYR----- 325
LLE K L + E EN++K EN+ L+
Sbjct: 614 KLLEDKREQLKKSKEHEKLMEGELEALRQEFKKKDKTLKENSRKLEEENENLRAELQCCS 673
Query: 326 ---KDHLGHINECLKVLQEKLEKSENKMEEKLLQLSSKVENFINTQKQETQLSKVKHMEN 382
+ L N +V+Q+ L K +E L+ L ++++ + +K Q + K +
Sbjct: 674 TQLESSLNKYNTSQQVIQD-LNKEIALQKESLMSLQAQLDKALQKEKHYLQTTITKEAYD 732
Query: 383 KLSKKMEQMEKQIWGELETMQNEYQSGFKSIHDSLSSLQQIQKTKMDLEKYKVQKDLKKL 442
LS+K + + LE + N S KS+ SL+ Q+ +K +++ E ++ +KKL
Sbjct: 733 ALSRKSAACQDDLTQALEKL-NHVTSETKSLQQSLTQTQE-KKAQLEEEIIAYEERMKKL 790
Query: 443 QRKIVELQ 450
++ +L+
Sbjct: 791 NTELRKLR 798
Score = 53.1 bits (126), Expect = 5e-07
Identities = 68/341 (19%), Positives = 148/341 (43%), Gaps = 63/341 (18%)
Query: 150 RKEESLARKLLESHIQTITSIVKKLSQNIEILEDQIRARDQAATGTNFAVHEIN-----I 204
+KE S+A K S+ + + + +LS+ + LE+ + + Q ++N I
Sbjct: 532 QKESSMAEKEQTSNRKRVEELSLELSEALRKLENSDKEKRQLQKTVAEQDMKMNDMLDRI 591
Query: 205 KHL---QG----------------VGDLRGRVARCDSSIVKLSGDIHLFRQEHRQIEKAI 245
KH QG + D R ++ + + G++ RQE ++ +K +
Sbjct: 592 KHQHREQGSIKCKLEEDLQEATKLLEDKREQLKKSKEHEKLMEGELEALRQEFKKKDKTL 651
Query: 246 QEFVPALETLSKNLDMKVMQLLGKIETASSEQTSNLKMVQGDYRHEMNLLEFKFHSLSSN 305
+E LE ++NL ++ ++E++ ++ ++ +++Q D E+ L + SL +
Sbjct: 652 KENSRKLEEENENLRAELQCCSTQLESSLNKYNTSQQVIQ-DLNKEIALQKESLMSLQAQ 710
Query: 306 LYEEVENNKKWTENQFLKYRKD------------------HLGHINECLKVLQEKLEKSE 347
L + ++ K + + K D L H+ K LQ+ L +++
Sbjct: 711 LDKALQKEKHYLQTTITKEAYDALSRKSAACQDDLTQALEKLNHVTSETKSLQQSLTQTQ 770
Query: 348 NK---MEEKLLQLSSKVENFINTQKQETQLSKVK--HMENKL-----SKKMEQMEKQIWG 397
K +EE+++ ++ +K T+L K++ H E++L KK+E+M Q+
Sbjct: 771 EKKAQLEEEIIAYEERM------KKLNTELRKLRGFHQESELEVHAFDKKLEEMSCQVL- 823
Query: 398 ELETMQNEYQSGFKSIHDSLSSLQQIQKTKMDLEKYKVQKD 438
Q ++Q+ K + L++ Q+ L++ ++ D
Sbjct: 824 ---QWQKQHQNDLKMLAAKEEQLREFQEEMAALKENLLEDD 861
Score = 35.0 bits (79), Expect = 0.14
Identities = 72/334 (21%), Positives = 142/334 (42%), Gaps = 56/334 (16%)
Query: 128 LLEQAFRIKEDISACLQ---GTHGFRKEESLARKLLESHIQTITSIVKKLSQNIEILEDQ 184
LL ++KED + G H E L L + + + L +++ + D+
Sbjct: 127 LLHHHCKLKEDEVILYEEEMGNHNENTGEKL--HLAQEQLALAGDKIASLERSLNLYRDK 184
Query: 185 IRARDQAATGTNFAVHEINIKHLQG-VGDLRGRVA--RCDSSIVKLSGDIHLFRQEHRQI 241
++ + +N + E +K LQG +G + G+ + D S V++ + QEH++
Sbjct: 185 YQS-----SLSNIELLECQVKMLQGELGGIMGQEPENKGDHSKVRIYTSPCMI-QEHQET 238
Query: 242 EKAIQEFVPALETLSKNLDMKVMQLLGKIETASS---EQTSNLKMVQGDYRHEMNLLEFK 298
+K + E + +S+ D+ + +L K+ +++ E+ L +Q D+
Sbjct: 239 QKRLSE---VWQKVSQQDDL-IQELRNKLACSNALVLEREKALIKLQADFASCTAT---- 290
Query: 299 FHSLSSNLYEEVENNKKWTENQFLKYRKDHLGHINECLKVLQEKLEKSENKMEEKLLQLS 358
H + EE E+ KK ++ L+ +KD ++CL V E+ +N +++ ++L
Sbjct: 291 -HRYPPSSSEECEDIKKILKH--LQEQKD-----SQCLHV-----EEYQNLVKDLRVELE 337
Query: 359 SKVENFINTQKQETQLSKVKHMENKLSKKMEQMEKQIWGELETMQNEYQSGFKSIHDSLS 418
+ V + + K M ++E + G E + K I
Sbjct: 338 A-----------------VSEQKRNIMKDMMKLELDLHGLREETSAHIERKDKDITILQC 380
Query: 419 SLQQIQKTKMDLEKYKVQKDLKKLQRKIVELQEV 452
LQ++Q + +K ++KD K LQ K LQE+
Sbjct: 381 RLQELQLEFTETQKLTLKKD-KFLQEKDEMLQEL 413
>gi|214010216 SMC6 protein [Homo sapiens]
Length = 1091
Score = 53.5 bits (127), Expect = 4e-07
Identities = 58/275 (21%), Positives = 123/275 (44%), Gaps = 40/275 (14%)
Query: 160 LESHIQTITSIVKKLSQNIEILEDQIRARDQAATGTNFAVHEINIKHLQGVGDLRGRVAR 219
LE+ ++ T+ + L Q++ LE I+ ++ E+ +K + + ++R
Sbjct: 671 LENEVENKTAQILNLQQHLSALEKDIKHNEELLKRCQLHYKELKMKIRKNISEIR----- 725
Query: 220 CDSSIVKLSGDIHLFRQEHRQIEKAIQEFVPALETLSKNLDMKVMQLLGKIETASSEQTS 279
+L +EH+ ++ A E A E SK M+++ + E
Sbjct: 726 ------ELENI-----EEHQSVDIATLED-EAQENKSK------MKMVEEHMEQQKENME 767
Query: 280 NLKMVQGDYRHEMNLLEFKFHSLSS---------NLYEEVENNKKWTENQFLKYRKDHLG 330
+LK ++ + ++ + ++FK + LS NL + +N+K + + + +K+HL
Sbjct: 768 HLKSLKIEAENKYDAIKFKINQLSELADPLKDELNLADSEVDNQKRGKRHYEEKQKEHLD 827
Query: 331 HINECLKVLQEKLEKSENKMEEKLLQLSSKVENFINTQKQETQLSKVKHMENKLSKKMEQ 390
+N+ + +L+ E ++EEK+ Q I +K + L K N+L +K+ Q
Sbjct: 828 TLNK----KKRELDMKEKELEEKMSQARQICPERIEVEKSASILDK---EINRLRQKI-Q 879
Query: 391 MEKQIWGELETMQNEYQSGFKSIHDSLSSLQQIQK 425
E G+ E + +YQ ++ D S ++ ++K
Sbjct: 880 AEHASHGDREEIMRQYQEARETYLDLDSKVRTLKK 914
>gi|13375848 SMC6 protein [Homo sapiens]
Length = 1091
Score = 53.5 bits (127), Expect = 4e-07
Identities = 58/275 (21%), Positives = 123/275 (44%), Gaps = 40/275 (14%)
Query: 160 LESHIQTITSIVKKLSQNIEILEDQIRARDQAATGTNFAVHEINIKHLQGVGDLRGRVAR 219
LE+ ++ T+ + L Q++ LE I+ ++ E+ +K + + ++R
Sbjct: 671 LENEVENKTAQILNLQQHLSALEKDIKHNEELLKRCQLHYKELKMKIRKNISEIR----- 725
Query: 220 CDSSIVKLSGDIHLFRQEHRQIEKAIQEFVPALETLSKNLDMKVMQLLGKIETASSEQTS 279
+L +EH+ ++ A E A E SK M+++ + E
Sbjct: 726 ------ELENI-----EEHQSVDIATLED-EAQENKSK------MKMVEEHMEQQKENME 767
Query: 280 NLKMVQGDYRHEMNLLEFKFHSLSS---------NLYEEVENNKKWTENQFLKYRKDHLG 330
+LK ++ + ++ + ++FK + LS NL + +N+K + + + +K+HL
Sbjct: 768 HLKSLKIEAENKYDAIKFKINQLSELADPLKDELNLADSEVDNQKRGKRHYEEKQKEHLD 827
Query: 331 HINECLKVLQEKLEKSENKMEEKLLQLSSKVENFINTQKQETQLSKVKHMENKLSKKMEQ 390
+N+ + +L+ E ++EEK+ Q I +K + L K N+L +K+ Q
Sbjct: 828 TLNK----KKRELDMKEKELEEKMSQARQICPERIEVEKSASILDK---EINRLRQKI-Q 879
Query: 391 MEKQIWGELETMQNEYQSGFKSIHDSLSSLQQIQK 425
E G+ E + +YQ ++ D S ++ ++K
Sbjct: 880 AEHASHGDREEIMRQYQEARETYLDLDSKVRTLKK 914
>gi|58530840 desmoplakin isoform I [Homo sapiens]
Length = 2871
Score = 53.1 bits (126), Expect = 5e-07
Identities = 66/315 (20%), Positives = 147/315 (46%), Gaps = 41/315 (13%)
Query: 110 QRGQLEDRLNNQARTIAFLLEQAFRIKEDIS-ACLQGTHGFRKEESLARKLLES--HIQT 166
++ + ++ L + + L Q + +E + A L+ H + E +R L ES I+
Sbjct: 1646 EKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNESKIEIER 1705
Query: 167 ITSIVKKLSQNIEILEDQIR----ARDQAATGTNFAVHEINIKHLQGVGDLRGRVARCDS 222
+ S+ + L++ +LE+++R D G + A + N L+ LR ++ ++
Sbjct: 1706 LQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSDKNATILE----LRSQLQISNN 1761
Query: 223 SIVKLSGDIHLFRQEHRQIEKAIQEFVP-ALETL-----SKNLDMKVMQ----LLGKIET 272
++L G I+ ++E + + I++F ALE SKN +V+Q LL KI+
Sbjct: 1762 RTLELQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQVVQERESLLVKIKV 1821
Query: 273 ASSEQTSNLKMVQGDYRHEMNLLEFKFHSLSSNLYEEVENNKKWTENQFLKYRKDHLGHI 332
++ + L+ ++ + + LE + + + + +E K+ +N +++ +
Sbjct: 1822 LEQDK-ARLQRLEDELNRAKSTLEAE-----TRVKQRLECEKQQIQNDLNQWKTQY-SRK 1874
Query: 333 NECLKVLQEKLEKSENKMEEKLLQLSSKVENFINTQKQETQLSKVKHMENKLSKKMEQME 392
E ++ ++ + EKSE + L S++E +++K +E + +K+E
Sbjct: 1875 EEAIRKIESEREKSEREKNS----LRSEIERL---------QAEIKRIEERCRRKLEDST 1921
Query: 393 KQIWGELETMQNEYQ 407
++ +LET ++ YQ
Sbjct: 1922 RETQSQLETERSRYQ 1936
Score = 35.8 bits (81), Expect = 0.082
Identities = 65/359 (18%), Positives = 152/359 (42%), Gaps = 42/359 (11%)
Query: 117 RLNNQARTIAFLLEQAFRIKEDISACLQGTHGFRKEESLARKLLESHIQTITSIVKKLSQ 176
+++N R L E+ R+K ++ Q T R+ +E IQ + ++SQ
Sbjct: 1394 QIDNLTRENRSLSEEIKRLKNTLT---QTTENLRR--------VEEDIQQQKATGSEVSQ 1442
Query: 177 NIEILEDQIRARDQAATGTNFAVHEINIKHLQGVGDLRGRVARCDSSIVKLSGDIHLFRQ 236
+ LE ++R Q T + + + + D + R I K + D
Sbjct: 1443 RKQQLEVELRQVTQMRTEESVRYKQSLDDAAKTIQDKNKEIERLKQLIDKETNDRKCLED 1502
Query: 237 EHRQIEKAIQEFVPALETLSKNL------DMKVMQLLGKIETASSEQT------------ 278
E+ ++++ + A + ++ + + ++ +L E S E+T
Sbjct: 1503 ENARLQRVQYDLQKANSSATETINKLKVQEQELTRLRIDYERVSQERTVKDQDITRFQNS 1562
Query: 279 -SNLKMVQGDYRHEMNLLEFKFHSLS---SNLYEEVENNKKWTENQFLKYRKDHLGHINE 334
L++ + E+N L+ S L EE+E ++ + Q +K + ++ +
Sbjct: 1563 LKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIK-----ITNLTQ 1617
Query: 335 CLKVLQEKLEKSENKMEEKLLQLSSKVENFINTQKQETQL-SKVKHMENKLSKKMEQMEK 393
L+ ++SE+ + ++ L + TQ++ +L S+V+ + +L ++ E + K
Sbjct: 1618 QLEQASIVKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESV-K 1676
Query: 394 QIWGELETMQNEYQSGFKSIHDSLSSLQQIQKTKMDL--EKYKVQKDLKKLQRKIVELQ 450
Q E Q + +S+++S ++++Q +L E ++++L+ L+ + +L+
Sbjct: 1677 QAHLRNEHFQKAIEDKSRSLNESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLR 1735
Score = 30.4 bits (67), Expect = 3.4
Identities = 19/68 (27%), Positives = 37/68 (54%), Gaps = 1/68 (1%)
Query: 307 YEEVENNKKWTENQFLKYRKDHLGHINECLKVLQEKLEKSENKMEEKLLQLSSKVENFIN 366
+EE ++ + + + RK + N L+ L E++++ E K EK+L+ +V+N +N
Sbjct: 382 FEEAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLEQIKELE-KEREKILEYKRQVQNLVN 440
Query: 367 TQKQETQL 374
K+ QL
Sbjct: 441 KSKKIVQL 448
>gi|33188443 microfilament and actin filament cross-linker protein
isoform b [Homo sapiens]
Length = 5938
Score = 53.1 bits (126), Expect = 5e-07
Identities = 77/347 (22%), Positives = 149/347 (42%), Gaps = 41/347 (11%)
Query: 114 LEDRLNNQARTIAFLLEQAFRIKEDISACLQGTHGFRKEESLARKLLESHIQTITSIVKK 173
++D+L + L + R+ ++ L H F+ L++ +Q + V+K
Sbjct: 2404 VKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADS----LQAWMQACEANVEK 2459
Query: 174 L-----SQNIEILEDQIRARDQAATGTNFAVHEINIKHLQGVGDLRGRVARCDSSIVKLS 228
L + + +L++Q+ Q A H++ ++ LQ +VAR I+++
Sbjct: 2460 LLSDTVASDPGVLQEQLATTKQLQE--ELAEHQVPVEKLQ-------KVAR---DIMEIE 2507
Query: 229 GDIHLFRQEHRQIEKAIQEFVPALETLSKNLDMKVMQLLGKIETASSEQTSNLKMVQGDY 288
G+ +HR +++ + ++LS +L + L I + S Q S ++Q
Sbjct: 2508 GEP---APDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIG 2564
Query: 289 RHEMNLLEFKFHSLSSNLYEE-VENNKKWTENQFLKYRKDHLGHINECLKVLQEKLEKSE 347
E NL + SLSS + +E + N K Q + +K L E + E + +
Sbjct: 2565 EVEQNLEGKQVSSLSSGVIQEALATNMKL--KQDIARQKSSLEATREMVTRFMETADSTT 2622
Query: 348 NK-MEEKLLQLSSKVENF-INTQKQETQLSKV---KHMENKLSKKMEQMEKQIWGELETM 402
++ KL ++S + E + Q++E+ L K+ M LS K++Q +E
Sbjct: 2623 AAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQF-------MENK 2675
Query: 403 QNEYQSGFKSIHDSLSSLQQIQKTKMDLEKYKVQKDLKKLQRKIVEL 449
SG + D QQIQ+ +++E Q++L L+ + EL
Sbjct: 2676 SRMLASGNQPDQDITHFFQQIQELNLEMEDQ--QENLDTLEHLVTEL 2720
Score = 37.0 bits (84), Expect = 0.037
Identities = 50/251 (19%), Positives = 105/251 (41%), Gaps = 37/251 (14%)
Query: 207 LQGVGDLRGRVARCDSSIVKLSGDIHLFRQEHRQIEKAIQEFVPALETLSKNLDMKVMQL 266
LQ DL+ +A + + L+ DI F EH Q LS + ++++L
Sbjct: 1963 LQQYEDLKQPMAERKAQLDALAFDIQFFISEHAQ-------------DLSPQQNRQMLRL 2009
Query: 267 LGKIETASS---EQT-SNLKMVQGDYRH-EMNLLEFKFHSLSSNLYEEVENNKKWTENQF 321
L +++ + EQT + + +QG + E L + ++++E+ W
Sbjct: 2010 LNELQRSFQDILEQTAAQVDALQGHLQQMEQEALVKTLQKQQNTCHQQLEDLCSWVG--- 2066
Query: 322 LKYRKDHLGHINECLKVLQEKLEKSENKMEEKLLQLSSKVENFINTQK------QETQLS 375
+ + GH + L+K+++ +++ + ++ +F K +E Q
Sbjct: 2067 -QAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTK 2125
Query: 376 KVKHMENKLSKKMEQMEKQIWGELETMQNEYQSGFKSIHDSLSSLQQIQKTKMDLEKYKV 435
L +K+ Q ++Q E +Q E + K + ++++S Q + EK K
Sbjct: 2126 LSPRELTALREKLHQAKEQ----YEALQEETRVAQKELEEAVTSALQ-----QETEKSKA 2176
Query: 436 QKDLKKLQRKI 446
K+L + ++KI
Sbjct: 2177 AKELAENKKKI 2187
Score = 35.8 bits (81), Expect = 0.082
Identities = 69/338 (20%), Positives = 139/338 (41%), Gaps = 31/338 (9%)
Query: 110 QRGQLEDRLNNQARTIAFLLEQAFRIKEDISACLQGTHGFRKEESLARKLLESHIQTITS 169
Q Q+ LN R+ +LEQ + + LQ + E+ K L+ T
Sbjct: 2002 QNRQMLRLLNELQRSFQDILEQTAAQVDALQGHLQ-----QMEQEALVKTLQKQQNTCHQ 2056
Query: 170 IVKKLSQNIEILEDQIRARDQAATGTNFAVHEINIKHLQGVGDLRGRVARCDSSIVKLSG 229
++ L + E + T + + + N L+ DL+ + +S +
Sbjct: 2057 QLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLK---DLQDDIQNRATSFATVVK 2113
Query: 230 DIHLFRQEHRQ---------IEKAIQEFVPALETLSKNLDMKVMQLLGKIETASSEQTSN 280
DI F +E++ + + + + E L + + +L + +A ++T
Sbjct: 2114 DIEGFMEENQTKLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEK 2173
Query: 281 LKMVQ--GDYRHEMNLLEFKFHSLSSNLYEEVENNKKWTENQFLKYRKDHLGHINECLKV 338
K + + + +++ L S+ S+ + + N + K L + + V
Sbjct: 2174 SKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDGYMGV 2233
Query: 339 LQ--EKLEKSENKMEEKLLQLSSKVENFI-NTQKQETQLSKVKHMENKLSKKMEQMEKQI 395
Q EKL+K M+ + +L S+ +NFI TQ + L + H L+ + +QM +Q
Sbjct: 2234 NQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGH---NLTPEEQQMLQQK 2290
Query: 396 WGELETMQNEYQSGFKSIHDSLSSLQQIQKTKMDLEKY 433
GEL + +Y + S+ S + L+Q+Q + +L+K+
Sbjct: 2291 LGEL---KEQYST---SLAQSEAELKQVQTLQDELQKF 2322
Score = 33.1 bits (74), Expect = 0.53
Identities = 97/399 (24%), Positives = 158/399 (39%), Gaps = 80/399 (20%)
Query: 113 QLEDRLNNQARTIAFLLEQAFRIKEDISACLQGTHGFRKEESLARKLLE----SHIQTIT 168
Q +DR+ N + L + ++D S+C + FRK +K L+ S T T
Sbjct: 2731 QHQDRVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTET 2790
Query: 169 SI-VKKLSQNIEILEDQIRARDQAATGTNFAVHEINIKH--------------------- 206
S+ K+L + IE L+ + D A+ GT V EIN K
Sbjct: 2791 SMSAKELEKQIEHLKSLLD--DWASKGT--LVEEINCKGTSLENLIMEITAPDSQGKTGS 2846
Query: 207 -LQGVGDLRGRV-----------ARCDSSIV-----KLSGDIHLFRQEHRQ-----IEKA 244
L VG G V +CD S V KL G +H RQE Q +E+
Sbjct: 2847 ILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHE-RQESLQAILNRMEEV 2905
Query: 245 IQEFVPALETL-SKNLDMKVMQLLG---KIETASSEQTSNLKMVQGDYRHEMNLLEFKFH 300
+E L+ L SK +K M + K ET ++ SN + ++ + + K
Sbjct: 2906 HKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVK-E 2964
Query: 301 SLSSNLY-----EEVENNKKWTENQFLKYRKDHLGHINECLKVLQEKLEKSENKMEEKLL 355
+L+ L +E EN KK E ++ + E Q +LE+S + L
Sbjct: 2965 ALAGLLVTYPNSQEAENWKKIQEELNSRWER-----ATEVTVARQRQLEESASH-----L 3014
Query: 356 QLSSKVENFINTQKQETQLSKVKHMENKLSKKMEQMEKQIWGELETMQNEYQSGFKSIHD 415
E+ + E +L + M +KQ +++ M E+++ + H+
Sbjct: 3015 ACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQ---QVQFMLKEFEAR-RQQHE 3070
Query: 416 SLSSLQQIQKT---KMDLEKYKVQKDLKKLQRKIVELQE 451
L+ Q T + L +VQK+L+ + +K VEL +
Sbjct: 3071 QLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTD 3109
>gi|33188445 microfilament and actin filament cross-linker protein
isoform a [Homo sapiens]
Length = 5430
Score = 53.1 bits (126), Expect = 5e-07
Identities = 77/347 (22%), Positives = 149/347 (42%), Gaps = 41/347 (11%)
Query: 114 LEDRLNNQARTIAFLLEQAFRIKEDISACLQGTHGFRKEESLARKLLESHIQTITSIVKK 173
++D+L + L + R+ ++ L H F+ L++ +Q + V+K
Sbjct: 1902 VKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADS----LQAWMQACEANVEK 1957
Query: 174 L-----SQNIEILEDQIRARDQAATGTNFAVHEINIKHLQGVGDLRGRVARCDSSIVKLS 228
L + + +L++Q+ Q A H++ ++ LQ +VAR I+++
Sbjct: 1958 LLSDTVASDPGVLQEQLATTKQLQE--ELAEHQVPVEKLQ-------KVAR---DIMEIE 2005
Query: 229 GDIHLFRQEHRQIEKAIQEFVPALETLSKNLDMKVMQLLGKIETASSEQTSNLKMVQGDY 288
G+ +HR +++ + ++LS +L + L I + S Q S ++Q
Sbjct: 2006 GEP---APDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIG 2062
Query: 289 RHEMNLLEFKFHSLSSNLYEE-VENNKKWTENQFLKYRKDHLGHINECLKVLQEKLEKSE 347
E NL + SLSS + +E + N K Q + +K L E + E + +
Sbjct: 2063 EVEQNLEGKQVSSLSSGVIQEALATNMKL--KQDIARQKSSLEATREMVTRFMETADSTT 2120
Query: 348 NK-MEEKLLQLSSKVENF-INTQKQETQLSKV---KHMENKLSKKMEQMEKQIWGELETM 402
++ KL ++S + E + Q++E+ L K+ M LS K++Q +E
Sbjct: 2121 AAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQF-------MENK 2173
Query: 403 QNEYQSGFKSIHDSLSSLQQIQKTKMDLEKYKVQKDLKKLQRKIVEL 449
SG + D QQIQ+ +++E Q++L L+ + EL
Sbjct: 2174 SRMLASGNQPDQDITHFFQQIQELNLEMEDQ--QENLDTLEHLVTEL 2218
Score = 34.7 bits (78), Expect = 0.18
Identities = 29/94 (30%), Positives = 52/94 (55%), Gaps = 10/94 (10%)
Query: 341 EKLEKSENKMEEKLLQLSSKVENFI-NTQKQETQLSKVKHMENKLSKKMEQMEKQIWGEL 399
EKL+K M+ + +L S+ +NFI TQ + L + H L+ + +QM +Q GEL
Sbjct: 1736 EKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGH---NLTPEEQQMLQQKLGEL 1792
Query: 400 ETMQNEYQSGFKSIHDSLSSLQQIQKTKMDLEKY 433
+ +Y + S+ S + L+Q+Q + +L+K+
Sbjct: 1793 ---KEQYST---SLAQSEAELKQVQTLQDELQKF 1820
Score = 33.9 bits (76), Expect = 0.31
Identities = 51/249 (20%), Positives = 99/249 (39%), Gaps = 48/249 (19%)
Query: 212 DLRGR----VARCDSSIVKLSGDIHLFRQEHRQIEKAIQEFVPALETLSKNLDMKVMQLL 267
DLR R V + +S + +E + +E+ QE V KV +LL
Sbjct: 1387 DLRTRYTALVTLTTQHVKYISDALRRLEEEEKVVEEEKQEHVE-----------KVKELL 1435
Query: 268 GKIETASSEQTSNLKMVQGDYRHEMNLLEFKFHSLSSNLYEEVENNKKWTENQFLKYR-K 326
G + T + + QG + SS E + K E Q L
Sbjct: 1436 GWVSTLA-------RNTQGK-------------ATSSETKESTDIEKAILEQQVLSEELT 1475
Query: 327 DHLGHINECLKVLQEKLEKSENKMEEKLLQLSSKVENFINTQKQET---QLSKVKHMENK 383
++E +K Q L K +K+ EK + S+ N +N + ++++ ++++
Sbjct: 1476 TKKEQVSEAIKTSQIFLAKHGHKLSEKEKKQISEQLNALNKAYHDLCDGSANQLQQLQSQ 1535
Query: 384 LSKKMEQMEKQIWGELETMQNEYQSGFKSIHDSLSSLQQIQKTKMDLEKYKVQKDLKKLQ 443
L+ + EQ +T+Q + + + + D S + Q ++ + Q+DL LQ
Sbjct: 1536 LAHQTEQ---------KTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQ 1586
Query: 444 RKIVELQEV 452
+ +L+++
Sbjct: 1587 KNQSDLKDL 1595
Score = 33.1 bits (74), Expect = 0.53
Identities = 97/399 (24%), Positives = 158/399 (39%), Gaps = 80/399 (20%)
Query: 113 QLEDRLNNQARTIAFLLEQAFRIKEDISACLQGTHGFRKEESLARKLLE----SHIQTIT 168
Q +DR+ N + L + ++D S+C + FRK +K L+ S T T
Sbjct: 2229 QHQDRVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTET 2288
Query: 169 SI-VKKLSQNIEILEDQIRARDQAATGTNFAVHEINIKH--------------------- 206
S+ K+L + IE L+ + D A+ GT V EIN K
Sbjct: 2289 SMSAKELEKQIEHLKSLLD--DWASKGT--LVEEINCKGTSLENLIMEITAPDSQGKTGS 2344
Query: 207 -LQGVGDLRGRV-----------ARCDSSIV-----KLSGDIHLFRQEHRQ-----IEKA 244
L VG G V +CD S V KL G +H RQE Q +E+
Sbjct: 2345 ILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHE-RQESLQAILNRMEEV 2403
Query: 245 IQEFVPALETL-SKNLDMKVMQLLG---KIETASSEQTSNLKMVQGDYRHEMNLLEFKFH 300
+E L+ L SK +K M + K ET ++ SN + ++ + + K
Sbjct: 2404 HKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVK-E 2462
Query: 301 SLSSNLY-----EEVENNKKWTENQFLKYRKDHLGHINECLKVLQEKLEKSENKMEEKLL 355
+L+ L +E EN KK E ++ + E Q +LE+S + L
Sbjct: 2463 ALAGLLVTYPNSQEAENWKKIQEELNSRWER-----ATEVTVARQRQLEESASH-----L 2512
Query: 356 QLSSKVENFINTQKQETQLSKVKHMENKLSKKMEQMEKQIWGELETMQNEYQSGFKSIHD 415
E+ + E +L + M +KQ +++ M E+++ + H+
Sbjct: 2513 ACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQ---QVQFMLKEFEAR-RQQHE 2568
Query: 416 SLSSLQQIQKT---KMDLEKYKVQKDLKKLQRKIVELQE 451
L+ Q T + L +VQK+L+ + +K VEL +
Sbjct: 2569 QLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTD 2607
>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
sapiens]
Length = 1940
Score = 52.8 bits (125), Expect = 6e-07
Identities = 80/371 (21%), Positives = 155/371 (41%), Gaps = 58/371 (15%)
Query: 115 EDRLNNQARTIAFLLEQAFRIKEDISACLQGTHGFRKEESLARKLLESHIQTITSIVKKL 174
E+++ N ++ L E ++ + A LQ H ++ A E + ++ KL
Sbjct: 973 ENKVKNLTEELSGLDETIAKLTREKKA-LQEAHQQALDDLQAE---EDKVNSLNKTKSKL 1028
Query: 175 SQNIEILEDQIRARDQAATGTNFAVHEINIKHLQGVGDLRGRVARCDSSIVKLSGDIHLF 234
Q +E LE + + E N + L+G DL+ SI+ L D
Sbjct: 1029 EQQVEDLESSLEQEKKLRVDL-----ERNKRKLEG--DLK----LAQESILDLENDKQQL 1077
Query: 235 --RQEHRQIEKA-IQEFVPALETLSKNLDMKVMQLLGKIETASSE------QTSNLKMVQ 285
R + + E +Q V +TL K+ +L +IE E + + +
Sbjct: 1078 DERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQR 1137
Query: 286 GDYRHEMNLLEFKFHSLSSNLYEEVENNKKWTENQFLKYRKD------------------ 327
DY E+ L + ++E NKK E +FLK R+D
Sbjct: 1138 SDYARELEELSERLEEAGGVTSTQIELNKK-REAEFLKLRRDLEEATLQHEAMVAALRKK 1196
Query: 328 ------HLGHINECLKVLQEKLEKSENKMEEKLLQLSSKVENFINTQKQETQLSKV-KHM 380
LG + L+ +++KLEK +++ + ++ LSS +E + K + L K+ + +
Sbjct: 1197 HADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSME---SVSKSKANLEKICRTL 1253
Query: 381 ENKLSK---KMEQMEKQIWGELETMQNEYQSGFKSIHDSLSSLQQIQKTKMDLEKYKVQK 437
E++LS+ K E++++ + EL T ++ Q+ + L + I +++ K +
Sbjct: 1254 EDQLSEARGKNEEIQRSL-SELTTQKSRLQTEAGELSRQLEEKESI-VSQLSRSKQAFTQ 1311
Query: 438 DLKKLQRKIVE 448
++L+R++ E
Sbjct: 1312 QTEELKRQLEE 1322
Score = 43.5 bits (101), Expect = 4e-04
Identities = 54/236 (22%), Positives = 108/236 (45%), Gaps = 31/236 (13%)
Query: 245 IQEFVPALETLSKNLDMKVMQLLGKIETASSE-QTSNLKMVQGDYRHEMNLLEFKFHSLS 303
I+ + + ET + MK K E A SE + L+ E N L+ + + S
Sbjct: 837 IKPLLKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAES 896
Query: 304 SNLYEEVENNKKWTENQF-LKYRKDHLGHINECLKVLQEKLEKSENKMEEKLLQLSSKVE 362
NL + E + + +F L+ + + E + + +L + K+E++ +L ++
Sbjct: 897 ENLLDAEERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDID 956
Query: 363 NF------INTQKQETQLSKVKHMENKLS-------------KKMEQMEKQIWGELETMQ 403
+ + +K T+ +KVK++ +LS K +++ +Q +L+ +
Sbjct: 957 DLELTLAKVEKEKHATE-NKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEE 1015
Query: 404 NEYQSGFKS-------IHDSLSSLQQIQKTKMDLE--KYKVQKDLKKLQRKIVELQ 450
++ S K+ + D SSL+Q +K ++DLE K K++ DLK Q I++L+
Sbjct: 1016 DKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLE 1071
Score = 42.4 bits (98), Expect = 9e-04
Identities = 35/146 (23%), Positives = 68/146 (46%), Gaps = 5/146 (3%)
Query: 309 EVENNKKWTENQFLKYRKDHLGHINECLKVLQEKLEKSENKMEEKLLQLSSKVENFINTQ 368
E E + +F K KD L K L+EKL + + LQ+ ++ EN ++ +
Sbjct: 845 ETEKEMATMKEEFQK-TKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAE 903
Query: 369 KQETQLSKVK-HMENKLSKKMEQM--EKQIWGELETMQNEYQSGFKSIHDSLSSLQQIQK 425
++ QL K K +E K+ + E+ E++I EL + + + + + L ++
Sbjct: 904 ERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDL-ELTL 962
Query: 426 TKMDLEKYKVQKDLKKLQRKIVELQE 451
K++ EK+ + +K L ++ L E
Sbjct: 963 AKVEKEKHATENKVKNLTEELSGLDE 988
Score = 40.4 bits (93), Expect = 0.003
Identities = 69/366 (18%), Positives = 146/366 (39%), Gaps = 62/366 (16%)
Query: 128 LLEQAFRIKEDISACLQGTHGFRKEESLARKLLESHIQTITSIVKKLSQNIEILEDQIRA 187
L + F++K L ++E K LE I +T + + + I LE +
Sbjct: 1478 LSTELFKLKNAYEEALDQLETVKREN----KNLEQEIADLTEQIAENGKTIHELEKSRKQ 1533
Query: 188 RDQAATGTNFAVHEIN--IKHLQGVGDLRGRVARCDSSIVKLSGDI-HLFRQEHRQIEKA 244
+ A+ E ++H + ++ R + ++ +I ++ +IE+
Sbjct: 1534 IELEKADIQLALEEAEAALEHEEA------KILRIQLELTQVKSEIDRKIAEKDEEIEQL 1587
Query: 245 IQEFVPALETLSKNLDMKV------MQLLGKIE--------------TASSEQTSNLKMV 284
+ + +ET+ LD +V ++L K+E ++E +L+ V
Sbjct: 1588 KRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSV 1647
Query: 285 QG-----------------DYRHEMNLLEFKFHSLSSNLYEEVENNKKWTENQFLKYRKD 327
QG D + ++ ++E + + L + + EE+ + TE K +
Sbjct: 1648 QGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEV-EELRATLEQTERA-RKLAEQ 1705
Query: 328 HLGHINECLKVLQEK---LEKSENKMEEKLLQLSSKVENFINTQKQETQLSKVKHMENKL 384
L NE +++L + L ++ K+E L+QL S+VE+ + + +K + +
Sbjct: 1706 ELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAM 1765
Query: 385 SKKMEQMEKQIWGELETMQNEYQSGFKSIHDSLSSLQQIQKTKMDLEKYKVQKDLKKLQR 444
+ + E+ LE M+ + K + L +Q L +K ++KL+
Sbjct: 1766 MAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQ-------LALKGGKKQIQKLET 1818
Query: 445 KIVELQ 450
+I EL+
Sbjct: 1819 RIRELE 1824
>gi|51472437 PREDICTED: golgi autoantigen, golgin subfamily a, 6C
isoform 1 [Homo sapiens]
Length = 693
Score = 52.4 bits (124), Expect = 8e-07
Identities = 69/346 (19%), Positives = 145/346 (41%), Gaps = 43/346 (12%)
Query: 121 QARTIAFLLEQAFRIKEDISACLQGTHGFRKEESLARKLLESHIQTITSIVKKLSQNIEI 180
+++ +A L+ + + +++ L ++EE + E+ +Q ++L Q I+
Sbjct: 154 ESKDLAGRLQYSLQRIQELERALSAVSTQQQEEDRSSSCREAVLQ------RRLQQTIK- 206
Query: 181 LEDQIRARDQAATGTNFAVHEINIKHLQGVGDLRGRVARCDSSIVKLSGDIHLFRQEHRQ 240
+ + T ++ ++ ++ + ++G AR + K+S + ++E ++
Sbjct: 207 ---ERALLNAHVTQVTESLKQVQLERDEYAKHIKGERARWQERMWKMSVEARTLKEEKKR 263
Query: 241 IEKAIQEFVPALETLSKNLDMKVMQLLGKIETASSEQTSNLKMVQGDYRHEMNLLEFKFH 300
IQE +L L Q+ A TS ++ +Q + +H L +
Sbjct: 264 DIHRIQELERSLSELKN-------QMAEPPSLAPPAVTSVVEQLQDEAKH----LRQEVE 312
Query: 301 SLSSNLYEEVENNKKWTENQFLKYRKDHLGHINECLKVL-------QEKLEKSENKMEEK 353
L L +VENN+ + K +K L E L+ QE+L + ++ E+
Sbjct: 313 GLEGKLQSQVENNQALS--LLSKEQKQRLQEQEEMLREQEAQRVREQERLCEQNERLREQ 370
Query: 354 LLQLSSKVENFINTQKQETQLSKVKHMENKLSKKMEQMEKQIWGELETM--------QNE 405
L + E +KQE +L K + K +++++ EK++W + E + + E
Sbjct: 371 QKTLQEQGERL---RKQEQRLRKQEERLRKEEERLQKQEKRLWDQEERLWKKEERLQKQE 427
Query: 406 YQSGFKSIHDSLSSLQQIQKTKMDLEKYKVQKDLKKLQRKIVELQE 451
+ H L + Q + DL K K +L++++ ELQE
Sbjct: 428 ERLALSQNHKLDKQLAEPQCSFEDLNNEK--KSALQLEQQVKELQE 471
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 52.4 bits (124), Expect = 8e-07
Identities = 67/348 (19%), Positives = 150/348 (43%), Gaps = 33/348 (9%)
Query: 109 TQRGQLEDRLNNQARTIAFLLEQAFRIKEDISACLQGTHGFRKEES-LARKL--LESHIQ 165
+ Q+++ A+ + L EQ + K + + KE + LA +L L Q
Sbjct: 1189 SHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQ 1248
Query: 166 TITSIVKKLSQNIEILEDQIRARDQAATGTNFAVHEINIKHLQGVGDLRGRVARCDSSIV 225
+ KKL ++ L+ + ++A N VH++ + V + G + + +
Sbjct: 1249 EVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNE----VESVTGMLNEAEGKAI 1304
Query: 226 KLSGDIHLFRQEHRQIEKAIQEFVPALETLSK-NLDMKVMQLLGKIETASSEQTSNLKMV 284
KL+ D+ + + ++ +QE ET K N+ K+ QL + + + ++
Sbjct: 1305 KLAKDVASLSSQLQDTQELLQE-----ETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAK 1359
Query: 285 QGDYRH------EMNLLEFKFHSLSSNLYEEVENNKKWTENQFLKYRKDHLGHINECLKV 338
Q RH +++ + K +S + E +E KK + + ++L E
Sbjct: 1360 QNLERHISTLNIQLSDSKKKLQDFASTV-EALEEGKKRFQKEI-----ENLTQQYEEKAA 1413
Query: 339 LQEKLEKSENKMEEKLLQLSSKVEN----FINTQKQETQLSKVKHMENKLSKKMEQMEKQ 394
+KLEK++N+++++L L ++N N +K++ + ++ E +S K +
Sbjct: 1414 AYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDR 1473
Query: 395 IWGELETMQNEYQSGFKSIHDSLSSLQQIQKT----KMDLEKYKVQKD 438
E + + S +++ ++L + +++++T K ++E KD
Sbjct: 1474 AEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKD 1521
Score = 45.8 bits (107), Expect = 8e-05
Identities = 64/300 (21%), Positives = 133/300 (44%), Gaps = 49/300 (16%)
Query: 151 KEESLARKLLESHIQTITSIVKKLSQNIEILEDQ----------IRARDQAATGTNFAVH 200
+EE AR+ L+ T + +KKL I +++DQ + R T TN A
Sbjct: 960 EEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLT-TNLAEE 1018
Query: 201 EINIKHLQGVGDLRGRVARCDSSIVKLSGDIHLFRQEHRQIEKAIQEFVPALETLSKNLD 260
E K+L + + + +S I +L ++ L ++ EK+ QE LE L + L+
Sbjct: 1019 EEKAKNLTKLKN------KHESMISEL--EVRLKKE-----EKSRQE----LEKLKRKLE 1061
Query: 261 MKVMQLLGKIETASSEQTSNLKMVQGDYRHEMNLLEFKFHSLSSNLYEEVENNKKWTENQ 320
EQ ++L+ + + ++ E + + + L +E+ +N
Sbjct: 1062 GDASDF--------HEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQ-----KNN 1108
Query: 321 FLKYRKDHLGHINECLKVL------QEKLEKSENKMEEKLLQLSSKVENFINTQKQETQL 374
LK ++ GHI++ + L + K EK + + E+L L +++E+ +++ + +L
Sbjct: 1109 ALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQEL 1168
Query: 375 SKVKHMENKLSKKMEQMEKQIWGELETMQNEYQSGFKSIHDSLSSLQQIQKTKMDLEKYK 434
+ E + KK ++++ +Q Q +++ + L+Q ++ K +L+K K
Sbjct: 1169 RAKREQEVTVLKK--ALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNK 1226
Score = 38.5 bits (88), Expect = 0.013
Identities = 70/378 (18%), Positives = 149/378 (39%), Gaps = 53/378 (14%)
Query: 121 QARTIAFLLEQAFRIKEDIS-------ACLQGTHGFRKEESLARKLLESHIQTITSIVKK 173
+A ++A LE+A KE++ A ++ + + LE + + + +++
Sbjct: 1484 KALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEE 1543
Query: 174 LSQNIEILEDQIRARDQAATGTNFAVHEINIKHLQGV--GDLRGRVARCDSSIVKLSGDI 231
+ +E LED+++A + A E+N++ L+G DL+ R + + +L +
Sbjct: 1544 MKTQLEELEDELQATEDAKLRL-----EVNMQALKGQFERDLQARDEQNEEKRRQLQRQL 1598
Query: 232 HLFRQEHRQIEKAIQEFVPALETLSKNLDMKVMQLLGKIETASSEQT-SNLKMVQGDYRH 290
H + E K Q + A D+K ++L E+ L+ +Q +
Sbjct: 1599 HEYETELEDERK--QRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKD 1656
Query: 291 EMNLLEFKFHSLSSNLYEEVENNKKWT--ENQFLKYRKDHLGH----------------- 331
LE S EN KK E ++ ++D
Sbjct: 1657 FQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEE 1716
Query: 332 ----------INECLKVLQEKLEKSENKMEEKLLQLSSKVENFINTQKQETQLSKVKHME 381
+ + + L+ ++ + E ++EE+ + + + +Q QLS E
Sbjct: 1717 LASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATE 1776
Query: 382 NKLSKK-------MEQMEKQIWGELETMQNEYQSGFKSIHDSLSSLQQIQKTKMDLEKYK 434
++K +E+ K++ +L M+ +S FKS +L + + +++ E +
Sbjct: 1777 RSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEARE 1836
Query: 435 VQKDLKKLQRKIVELQEV 452
Q K L++K +L+E+
Sbjct: 1837 KQAATKSLKQKDKKLKEI 1854
Score = 36.2 bits (82), Expect = 0.063
Identities = 42/191 (21%), Positives = 93/191 (48%), Gaps = 24/191 (12%)
Query: 276 EQTSNLKMVQGDYRHEMNLLEFKFHSLSSNLYEEVENNKKWTENQFLKYRKDHLGHINEC 335
+Q + +K++Q + + L +++ L + + ++ ++ E Q ++D L E
Sbjct: 811 QQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQA---KEDELQKTKE- 866
Query: 336 LKVLQEKLEKSENKMEEKLLQLSSKVENFINTQKQ-ETQL-SKVKHMENKLSKKMEQMEK 393
Q+K E ++E+K QL+ + +N + Q Q ET+L ++ + M +L+ K +++E
Sbjct: 867 ---RQQKAENELKELEQKHSQLTEE-KNLLQEQLQAETELYAEAEEMRVRLAAKKQELE- 921
Query: 394 QIWGELETMQNE-------YQSGFKSIHDSLSSLQQ------IQKTKMDLEKYKVQKDLK 440
+I E+E E Q+ K + + L++ + K+ LEK + +K
Sbjct: 922 EILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIK 981
Query: 441 KLQRKIVELQE 451
KL+ +I+ + +
Sbjct: 982 KLEDEILVMDD 992
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 52.4 bits (124), Expect = 8e-07
Identities = 67/348 (19%), Positives = 150/348 (43%), Gaps = 33/348 (9%)
Query: 109 TQRGQLEDRLNNQARTIAFLLEQAFRIKEDISACLQGTHGFRKEES-LARKL--LESHIQ 165
+ Q+++ A+ + L EQ + K + + KE + LA +L L Q
Sbjct: 1196 SHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQ 1255
Query: 166 TITSIVKKLSQNIEILEDQIRARDQAATGTNFAVHEINIKHLQGVGDLRGRVARCDSSIV 225
+ KKL ++ L+ + ++A N VH++ + V + G + + +
Sbjct: 1256 EVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNE----VESVTGMLNEAEGKAI 1311
Query: 226 KLSGDIHLFRQEHRQIEKAIQEFVPALETLSK-NLDMKVMQLLGKIETASSEQTSNLKMV 284
KL+ D+ + + ++ +QE ET K N+ K+ QL + + + ++
Sbjct: 1312 KLAKDVASLSSQLQDTQELLQE-----ETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAK 1366
Query: 285 QGDYRH------EMNLLEFKFHSLSSNLYEEVENNKKWTENQFLKYRKDHLGHINECLKV 338
Q RH +++ + K +S + E +E KK + + ++L E
Sbjct: 1367 QNLERHISTLNIQLSDSKKKLQDFASTV-EALEEGKKRFQKEI-----ENLTQQYEEKAA 1420
Query: 339 LQEKLEKSENKMEEKLLQLSSKVEN----FINTQKQETQLSKVKHMENKLSKKMEQMEKQ 394
+KLEK++N+++++L L ++N N +K++ + ++ E +S K +
Sbjct: 1421 AYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDR 1480
Query: 395 IWGELETMQNEYQSGFKSIHDSLSSLQQIQKT----KMDLEKYKVQKD 438
E + + S +++ ++L + +++++T K ++E KD
Sbjct: 1481 AEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKD 1528
Score = 45.8 bits (107), Expect = 8e-05
Identities = 64/300 (21%), Positives = 133/300 (44%), Gaps = 49/300 (16%)
Query: 151 KEESLARKLLESHIQTITSIVKKLSQNIEILEDQ----------IRARDQAATGTNFAVH 200
+EE AR+ L+ T + +KKL I +++DQ + R T TN A
Sbjct: 967 EEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLT-TNLAEE 1025
Query: 201 EINIKHLQGVGDLRGRVARCDSSIVKLSGDIHLFRQEHRQIEKAIQEFVPALETLSKNLD 260
E K+L + + + +S I +L ++ L ++ EK+ QE LE L + L+
Sbjct: 1026 EEKAKNLTKLKN------KHESMISEL--EVRLKKE-----EKSRQE----LEKLKRKLE 1068
Query: 261 MKVMQLLGKIETASSEQTSNLKMVQGDYRHEMNLLEFKFHSLSSNLYEEVENNKKWTENQ 320
EQ ++L+ + + ++ E + + + L +E+ +N
Sbjct: 1069 GDASDF--------HEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQ-----KNN 1115
Query: 321 FLKYRKDHLGHINECLKVL------QEKLEKSENKMEEKLLQLSSKVENFINTQKQETQL 374
LK ++ GHI++ + L + K EK + + E+L L +++E+ +++ + +L
Sbjct: 1116 ALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQEL 1175
Query: 375 SKVKHMENKLSKKMEQMEKQIWGELETMQNEYQSGFKSIHDSLSSLQQIQKTKMDLEKYK 434
+ E + KK ++++ +Q Q +++ + L+Q ++ K +L+K K
Sbjct: 1176 RAKREQEVTVLKK--ALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNK 1233
Score = 38.5 bits (88), Expect = 0.013
Identities = 70/378 (18%), Positives = 149/378 (39%), Gaps = 53/378 (14%)
Query: 121 QARTIAFLLEQAFRIKEDIS-------ACLQGTHGFRKEESLARKLLESHIQTITSIVKK 173
+A ++A LE+A KE++ A ++ + + LE + + + +++
Sbjct: 1491 KALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEE 1550
Query: 174 LSQNIEILEDQIRARDQAATGTNFAVHEINIKHLQGV--GDLRGRVARCDSSIVKLSGDI 231
+ +E LED+++A + A E+N++ L+G DL+ R + + +L +
Sbjct: 1551 MKTQLEELEDELQATEDAKLRL-----EVNMQALKGQFERDLQARDEQNEEKRRQLQRQL 1605
Query: 232 HLFRQEHRQIEKAIQEFVPALETLSKNLDMKVMQLLGKIETASSEQT-SNLKMVQGDYRH 290
H + E K Q + A D+K ++L E+ L+ +Q +
Sbjct: 1606 HEYETELEDERK--QRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKD 1663
Query: 291 EMNLLEFKFHSLSSNLYEEVENNKKWT--ENQFLKYRKDHLGH----------------- 331
LE S EN KK E ++ ++D
Sbjct: 1664 FQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEE 1723
Query: 332 ----------INECLKVLQEKLEKSENKMEEKLLQLSSKVENFINTQKQETQLSKVKHME 381
+ + + L+ ++ + E ++EE+ + + + +Q QLS E
Sbjct: 1724 LASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATE 1783
Query: 382 NKLSKK-------MEQMEKQIWGELETMQNEYQSGFKSIHDSLSSLQQIQKTKMDLEKYK 434
++K +E+ K++ +L M+ +S FKS +L + + +++ E +
Sbjct: 1784 RSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEARE 1843
Query: 435 VQKDLKKLQRKIVELQEV 452
Q K L++K +L+E+
Sbjct: 1844 KQAATKSLKQKDKKLKEI 1861
Score = 36.2 bits (82), Expect = 0.063
Identities = 42/191 (21%), Positives = 93/191 (48%), Gaps = 24/191 (12%)
Query: 276 EQTSNLKMVQGDYRHEMNLLEFKFHSLSSNLYEEVENNKKWTENQFLKYRKDHLGHINEC 335
+Q + +K++Q + + L +++ L + + ++ ++ E Q ++D L E
Sbjct: 818 QQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQA---KEDELQKTKE- 873
Query: 336 LKVLQEKLEKSENKMEEKLLQLSSKVENFINTQKQ-ETQL-SKVKHMENKLSKKMEQMEK 393
Q+K E ++E+K QL+ + +N + Q Q ET+L ++ + M +L+ K +++E
Sbjct: 874 ---RQQKAENELKELEQKHSQLTEE-KNLLQEQLQAETELYAEAEEMRVRLAAKKQELE- 928
Query: 394 QIWGELETMQNE-------YQSGFKSIHDSLSSLQQ------IQKTKMDLEKYKVQKDLK 440
+I E+E E Q+ K + + L++ + K+ LEK + +K
Sbjct: 929 EILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIK 988
Query: 441 KLQRKIVELQE 451
KL+ +I+ + +
Sbjct: 989 KLEDEILVMDD 999
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 52.4 bits (124), Expect = 8e-07
Identities = 67/348 (19%), Positives = 150/348 (43%), Gaps = 33/348 (9%)
Query: 109 TQRGQLEDRLNNQARTIAFLLEQAFRIKEDISACLQGTHGFRKEES-LARKL--LESHIQ 165
+ Q+++ A+ + L EQ + K + + KE + LA +L L Q
Sbjct: 1196 SHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQ 1255
Query: 166 TITSIVKKLSQNIEILEDQIRARDQAATGTNFAVHEINIKHLQGVGDLRGRVARCDSSIV 225
+ KKL ++ L+ + ++A N VH++ + V + G + + +
Sbjct: 1256 EVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNE----VESVTGMLNEAEGKAI 1311
Query: 226 KLSGDIHLFRQEHRQIEKAIQEFVPALETLSK-NLDMKVMQLLGKIETASSEQTSNLKMV 284
KL+ D+ + + ++ +QE ET K N+ K+ QL + + + ++
Sbjct: 1312 KLAKDVASLSSQLQDTQELLQE-----ETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAK 1366
Query: 285 QGDYRH------EMNLLEFKFHSLSSNLYEEVENNKKWTENQFLKYRKDHLGHINECLKV 338
Q RH +++ + K +S + E +E KK + + ++L E
Sbjct: 1367 QNLERHISTLNIQLSDSKKKLQDFASTV-EALEEGKKRFQKEI-----ENLTQQYEEKAA 1420
Query: 339 LQEKLEKSENKMEEKLLQLSSKVEN----FINTQKQETQLSKVKHMENKLSKKMEQMEKQ 394
+KLEK++N+++++L L ++N N +K++ + ++ E +S K +
Sbjct: 1421 AYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDR 1480
Query: 395 IWGELETMQNEYQSGFKSIHDSLSSLQQIQKT----KMDLEKYKVQKD 438
E + + S +++ ++L + +++++T K ++E KD
Sbjct: 1481 AEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKD 1528
Score = 45.8 bits (107), Expect = 8e-05
Identities = 64/300 (21%), Positives = 133/300 (44%), Gaps = 49/300 (16%)
Query: 151 KEESLARKLLESHIQTITSIVKKLSQNIEILEDQ----------IRARDQAATGTNFAVH 200
+EE AR+ L+ T + +KKL I +++DQ + R T TN A
Sbjct: 967 EEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLT-TNLAEE 1025
Query: 201 EINIKHLQGVGDLRGRVARCDSSIVKLSGDIHLFRQEHRQIEKAIQEFVPALETLSKNLD 260
E K+L + + + +S I +L ++ L ++ EK+ QE LE L + L+
Sbjct: 1026 EEKAKNLTKLKN------KHESMISEL--EVRLKKE-----EKSRQE----LEKLKRKLE 1068
Query: 261 MKVMQLLGKIETASSEQTSNLKMVQGDYRHEMNLLEFKFHSLSSNLYEEVENNKKWTENQ 320
EQ ++L+ + + ++ E + + + L +E+ +N
Sbjct: 1069 GDASDF--------HEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQ-----KNN 1115
Query: 321 FLKYRKDHLGHINECLKVL------QEKLEKSENKMEEKLLQLSSKVENFINTQKQETQL 374
LK ++ GHI++ + L + K EK + + E+L L +++E+ +++ + +L
Sbjct: 1116 ALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQEL 1175
Query: 375 SKVKHMENKLSKKMEQMEKQIWGELETMQNEYQSGFKSIHDSLSSLQQIQKTKMDLEKYK 434
+ E + KK ++++ +Q Q +++ + L+Q ++ K +L+K K
Sbjct: 1176 RAKREQEVTVLKK--ALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNK 1233
Score = 38.5 bits (88), Expect = 0.013
Identities = 70/378 (18%), Positives = 149/378 (39%), Gaps = 53/378 (14%)
Query: 121 QARTIAFLLEQAFRIKEDIS-------ACLQGTHGFRKEESLARKLLESHIQTITSIVKK 173
+A ++A LE+A KE++ A ++ + + LE + + + +++
Sbjct: 1491 KALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEE 1550
Query: 174 LSQNIEILEDQIRARDQAATGTNFAVHEINIKHLQGV--GDLRGRVARCDSSIVKLSGDI 231
+ +E LED+++A + A E+N++ L+G DL+ R + + +L +
Sbjct: 1551 MKTQLEELEDELQATEDAKLRL-----EVNMQALKGQFERDLQARDEQNEEKRRQLQRQL 1605
Query: 232 HLFRQEHRQIEKAIQEFVPALETLSKNLDMKVMQLLGKIETASSEQT-SNLKMVQGDYRH 290
H + E K Q + A D+K ++L E+ L+ +Q +
Sbjct: 1606 HEYETELEDERK--QRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKD 1663
Query: 291 EMNLLEFKFHSLSSNLYEEVENNKKWT--ENQFLKYRKDHLGH----------------- 331
LE S EN KK E ++ ++D
Sbjct: 1664 FQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEE 1723
Query: 332 ----------INECLKVLQEKLEKSENKMEEKLLQLSSKVENFINTQKQETQLSKVKHME 381
+ + + L+ ++ + E ++EE+ + + + +Q QLS E
Sbjct: 1724 LASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATE 1783
Query: 382 NKLSKK-------MEQMEKQIWGELETMQNEYQSGFKSIHDSLSSLQQIQKTKMDLEKYK 434
++K +E+ K++ +L M+ +S FKS +L + + +++ E +
Sbjct: 1784 RSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEARE 1843
Query: 435 VQKDLKKLQRKIVELQEV 452
Q K L++K +L+E+
Sbjct: 1844 KQAATKSLKQKDKKLKEI 1861
Score = 36.2 bits (82), Expect = 0.063
Identities = 42/191 (21%), Positives = 93/191 (48%), Gaps = 24/191 (12%)
Query: 276 EQTSNLKMVQGDYRHEMNLLEFKFHSLSSNLYEEVENNKKWTENQFLKYRKDHLGHINEC 335
+Q + +K++Q + + L +++ L + + ++ ++ E Q ++D L E
Sbjct: 818 QQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQA---KEDELQKTKE- 873
Query: 336 LKVLQEKLEKSENKMEEKLLQLSSKVENFINTQKQ-ETQL-SKVKHMENKLSKKMEQMEK 393
Q+K E ++E+K QL+ + +N + Q Q ET+L ++ + M +L+ K +++E
Sbjct: 874 ---RQQKAENELKELEQKHSQLTEE-KNLLQEQLQAETELYAEAEEMRVRLAAKKQELE- 928
Query: 394 QIWGELETMQNE-------YQSGFKSIHDSLSSLQQ------IQKTKMDLEKYKVQKDLK 440
+I E+E E Q+ K + + L++ + K+ LEK + +K
Sbjct: 929 EILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIK 988
Query: 441 KLQRKIVELQE 451
KL+ +I+ + +
Sbjct: 989 KLEDEILVMDD 999
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 52.4 bits (124), Expect = 8e-07
Identities = 67/348 (19%), Positives = 150/348 (43%), Gaps = 33/348 (9%)
Query: 109 TQRGQLEDRLNNQARTIAFLLEQAFRIKEDISACLQGTHGFRKEES-LARKL--LESHIQ 165
+ Q+++ A+ + L EQ + K + + KE + LA +L L Q
Sbjct: 1189 SHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQ 1248
Query: 166 TITSIVKKLSQNIEILEDQIRARDQAATGTNFAVHEINIKHLQGVGDLRGRVARCDSSIV 225
+ KKL ++ L+ + ++A N VH++ + V + G + + +
Sbjct: 1249 EVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNE----VESVTGMLNEAEGKAI 1304
Query: 226 KLSGDIHLFRQEHRQIEKAIQEFVPALETLSK-NLDMKVMQLLGKIETASSEQTSNLKMV 284
KL+ D+ + + ++ +QE ET K N+ K+ QL + + + ++
Sbjct: 1305 KLAKDVASLSSQLQDTQELLQE-----ETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAK 1359
Query: 285 QGDYRH------EMNLLEFKFHSLSSNLYEEVENNKKWTENQFLKYRKDHLGHINECLKV 338
Q RH +++ + K +S + E +E KK + + ++L E
Sbjct: 1360 QNLERHISTLNIQLSDSKKKLQDFASTV-EALEEGKKRFQKEI-----ENLTQQYEEKAA 1413
Query: 339 LQEKLEKSENKMEEKLLQLSSKVEN----FINTQKQETQLSKVKHMENKLSKKMEQMEKQ 394
+KLEK++N+++++L L ++N N +K++ + ++ E +S K +
Sbjct: 1414 AYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDR 1473
Query: 395 IWGELETMQNEYQSGFKSIHDSLSSLQQIQKT----KMDLEKYKVQKD 438
E + + S +++ ++L + +++++T K ++E KD
Sbjct: 1474 AEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKD 1521
Score = 45.8 bits (107), Expect = 8e-05
Identities = 64/300 (21%), Positives = 133/300 (44%), Gaps = 49/300 (16%)
Query: 151 KEESLARKLLESHIQTITSIVKKLSQNIEILEDQ----------IRARDQAATGTNFAVH 200
+EE AR+ L+ T + +KKL I +++DQ + R T TN A
Sbjct: 960 EEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLT-TNLAEE 1018
Query: 201 EINIKHLQGVGDLRGRVARCDSSIVKLSGDIHLFRQEHRQIEKAIQEFVPALETLSKNLD 260
E K+L + + + +S I +L ++ L ++ EK+ QE LE L + L+
Sbjct: 1019 EEKAKNLTKLKN------KHESMISEL--EVRLKKE-----EKSRQE----LEKLKRKLE 1061
Query: 261 MKVMQLLGKIETASSEQTSNLKMVQGDYRHEMNLLEFKFHSLSSNLYEEVENNKKWTENQ 320
EQ ++L+ + + ++ E + + + L +E+ +N
Sbjct: 1062 GDASDF--------HEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQ-----KNN 1108
Query: 321 FLKYRKDHLGHINECLKVL------QEKLEKSENKMEEKLLQLSSKVENFINTQKQETQL 374
LK ++ GHI++ + L + K EK + + E+L L +++E+ +++ + +L
Sbjct: 1109 ALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQEL 1168
Query: 375 SKVKHMENKLSKKMEQMEKQIWGELETMQNEYQSGFKSIHDSLSSLQQIQKTKMDLEKYK 434
+ E + KK ++++ +Q Q +++ + L+Q ++ K +L+K K
Sbjct: 1169 RAKREQEVTVLKK--ALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNK 1226
Score = 38.5 bits (88), Expect = 0.013
Identities = 70/378 (18%), Positives = 149/378 (39%), Gaps = 53/378 (14%)
Query: 121 QARTIAFLLEQAFRIKEDIS-------ACLQGTHGFRKEESLARKLLESHIQTITSIVKK 173
+A ++A LE+A KE++ A ++ + + LE + + + +++
Sbjct: 1484 KALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEE 1543
Query: 174 LSQNIEILEDQIRARDQAATGTNFAVHEINIKHLQGV--GDLRGRVARCDSSIVKLSGDI 231
+ +E LED+++A + A E+N++ L+G DL+ R + + +L +
Sbjct: 1544 MKTQLEELEDELQATEDAKLRL-----EVNMQALKGQFERDLQARDEQNEEKRRQLQRQL 1598
Query: 232 HLFRQEHRQIEKAIQEFVPALETLSKNLDMKVMQLLGKIETASSEQT-SNLKMVQGDYRH 290
H + E K Q + A D+K ++L E+ L+ +Q +
Sbjct: 1599 HEYETELEDERK--QRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKD 1656
Query: 291 EMNLLEFKFHSLSSNLYEEVENNKKWT--ENQFLKYRKDHLGH----------------- 331
LE S EN KK E ++ ++D
Sbjct: 1657 FQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEE 1716
Query: 332 ----------INECLKVLQEKLEKSENKMEEKLLQLSSKVENFINTQKQETQLSKVKHME 381
+ + + L+ ++ + E ++EE+ + + + +Q QLS E
Sbjct: 1717 LASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATE 1776
Query: 382 NKLSKK-------MEQMEKQIWGELETMQNEYQSGFKSIHDSLSSLQQIQKTKMDLEKYK 434
++K +E+ K++ +L M+ +S FKS +L + + +++ E +
Sbjct: 1777 RSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEARE 1836
Query: 435 VQKDLKKLQRKIVELQEV 452
Q K L++K +L+E+
Sbjct: 1837 KQAATKSLKQKDKKLKEI 1854
Score = 36.2 bits (82), Expect = 0.063
Identities = 42/191 (21%), Positives = 93/191 (48%), Gaps = 24/191 (12%)
Query: 276 EQTSNLKMVQGDYRHEMNLLEFKFHSLSSNLYEEVENNKKWTENQFLKYRKDHLGHINEC 335
+Q + +K++Q + + L +++ L + + ++ ++ E Q ++D L E
Sbjct: 811 QQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQA---KEDELQKTKE- 866
Query: 336 LKVLQEKLEKSENKMEEKLLQLSSKVENFINTQKQ-ETQL-SKVKHMENKLSKKMEQMEK 393
Q+K E ++E+K QL+ + +N + Q Q ET+L ++ + M +L+ K +++E
Sbjct: 867 ---RQQKAENELKELEQKHSQLTEE-KNLLQEQLQAETELYAEAEEMRVRLAAKKQELE- 921
Query: 394 QIWGELETMQNE-------YQSGFKSIHDSLSSLQQ------IQKTKMDLEKYKVQKDLK 440
+I E+E E Q+ K + + L++ + K+ LEK + +K
Sbjct: 922 EILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIK 981
Query: 441 KLQRKIVELQE 451
KL+ +I+ + +
Sbjct: 982 KLEDEILVMDD 992
>gi|239745127 PREDICTED: similar to Putative golgin subfamily A
member 6-like protein 6 [Homo sapiens]
Length = 655
Score = 52.0 bits (123), Expect = 1e-06
Identities = 63/321 (19%), Positives = 142/321 (44%), Gaps = 29/321 (9%)
Query: 150 RKEESLARKLLE-SHIQTITSIVKKLSQNIEILEDQIRARDQAATGTNFAVHEINIKHLQ 208
R E SL + L H + + ++KL++ + L ++ T T+ + E N + +
Sbjct: 170 RPENSLLEETLHFDHAVRMGTYIEKLTKERDALSLELYRN----TITDEELKEKNAELQE 225
Query: 209 GVGDLRGRVARCDSSIVKLSGDIHLFRQEHRQIEKAIQEFVPALETLSKNLDMKVMQLLG 268
+ R+ + S ++L+ + E Q+ Q+ + L K L +L
Sbjct: 226 KL-----RLVESEKSEIQLNVKDLKRKLERAQLLLPQQQLQVEADRLGKELQSVSAKLQA 280
Query: 269 KIETASSEQTSNLKMVQGDYRHEMNLLEFKFHSLSSNLYEEVENNKKWTENQFLKYRKDH 328
++E N + + +R E + E + L + K W + + + +++
Sbjct: 281 QVEENELWNLLNQQQEEKMWRQEEKIQEQEEKMCEQELKIREQEEKMWRQEEKMHEQEEK 340
Query: 329 LGHINECLKVLQEKLEKSENKM---EEKLLQLSSKV-ENFINTQKQETQL----SKVKHM 380
+ + + +EK+ + E K+ EEK+ + K+ E Q+QE ++ K++
Sbjct: 341 IREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQ 400
Query: 381 ENKLSKKMEQMEKQIWGELETMQNEYQSGFKS----------IHDSLSSLQQIQKTKMDL 430
E K +KM + EK++ + E ++ + + ++ + D L+++++ KM
Sbjct: 401 EEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEE-KMQE 459
Query: 431 EKYKVQKDLKKLQRKIVELQE 451
E+ K+Q+ +K+QR+ ++QE
Sbjct: 460 EEEKMQEQEEKIQRQEEKIQE 480
Score = 51.2 bits (121), Expect = 2e-06
Identities = 46/226 (20%), Positives = 106/226 (46%), Gaps = 22/226 (9%)
Query: 233 LFRQEHRQIEKAIQEFVPALETLSKNLDMKVMQLLGKIETASSE---QTSNLKMVQGDYR 289
++RQE + E+ +E + E + K+ + KI+ E Q ++ + +
Sbjct: 348 MWRQEEKIREQ--EEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQ 405
Query: 290 HEMNLLEFKFHSLSSNLYEEVENNKKWTENQFLKYRKDHLGHINECLKVLQEKLEKSENK 349
+M E K + E+ E + W + + ++ ++ + E L+ ++EK+++ E K
Sbjct: 406 EKMWRQEKKMREQDEKIREQEE--EMWRQEEKIRELEEMMQDQEEKLREVEEKMQEEEEK 463
Query: 350 MEEKLLQLSSKVENFINTQKQETQLSKVKHMENKL---SKKMEQMEKQIWGELETMQNEY 406
M+E+ ++ + E +++ + K+ E K+ +KM + E+++W + E MQ +
Sbjct: 464 MQEQEEKIQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEKMWEQEEKMQEQE 523
Query: 407 QSGFKSIHDSLSSLQQIQKTKMDLEKYKVQKDLKKLQRKIVELQEV 452
+ Q Q+ KM ++ ++ + +K+Q + V LQE+
Sbjct: 524 EK------------MQRQEEKMREQEVRLWQQEEKMQEQEVRLQEL 557
Score = 29.3 bits (64), Expect = 7.7
Identities = 32/215 (14%), Positives = 94/215 (43%), Gaps = 5/215 (2%)
Query: 149 FRKEESLARKLLESHIQTITSIVKKLSQNIEILEDQIRARDQAATGTNFAVHEINIKHLQ 208
+R+EE + + E I+ + + + I +++I+ +++ + E K +
Sbjct: 349 WRQEEKIREQ--EEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQE 406
Query: 209 GVGDLRGRVARCDSSIVKLSGDIHLFRQEHRQIEKAIQEFVPALETLSKNLDMKVMQLLG 268
+ ++ D I + ++ ++ R++E+ +Q+ L + + + + ++
Sbjct: 407 KMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEEEEKMQE 466
Query: 269 KIETASSEQTSNLKMVQGDYRHEMNLL-EFKFHSLSSNLYEEVENNKKWTENQFLKYRKD 327
+ E ++ + + +R E L E K ++ + E K W + + ++ +++
Sbjct: 467 QEEKIQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEE--KMWEQEEKMQEQEE 524
Query: 328 HLGHINECLKVLQEKLEKSENKMEEKLLQLSSKVE 362
+ E ++ + +L + E KM+E+ ++L E
Sbjct: 525 KMQRQEEKMREQEVRLWQQEEKMQEQEVRLQELEE 559
>gi|223634475 golgi autoantigen, golgin subfamily a, 6D [Homo
sapiens]
Length = 693
Score = 51.6 bits (122), Expect = 1e-06
Identities = 72/328 (21%), Positives = 134/328 (40%), Gaps = 62/328 (18%)
Query: 140 SACLQGTHGFRKEESLA-RKLLESHIQTITSIVKKLSQNIEILEDQIRARDQAATGTNFA 198
S+C + R ++++ R LL +H+ +T +K++ RD+ A
Sbjct: 190 SSCREAVLQRRLQQTIKERALLNAHVTQVTESLKQVQLE----------RDEYA------ 233
Query: 199 VHEINIKHLQGVGDLRGRVARCDSSIVKLSGDIHLFRQEHRQIEKAIQEFVPALETLSKN 258
KH+ +G AR + K+S + ++E ++ IQE +L L
Sbjct: 234 ------KHI------KGERARWQERMWKMSVEARTLKEEKKRDIHRIQELERSLSELKN- 280
Query: 259 LDMKVMQLLGKIETASSEQTSNLKMVQGDYRHEMNLLEFKFHSLSSNLYEEVENNKKWTE 318
Q+ A TS ++ +Q + +H L + L L +VENN+ +
Sbjct: 281 ------QMAEPPSLAPPAVTSVVEQLQDEAKH----LRQEVEGLEGKLQSQVENNQALS- 329
Query: 319 NQFLKYRKDHLGHINECLKVL-------QEKLEKSENKMEEKLLQLSSKVENFINTQKQE 371
K +K L E L+ QE+L + ++ E+ L + E +KQE
Sbjct: 330 -LLSKEQKQRLQEQEEMLREQEAQRVREQERLCEQNERLREQQKTLQEQGERL---RKQE 385
Query: 372 TQLSKVKHMENKLSKKMEQMEKQIWGELETM--------QNEYQSGFKSIHDSLSSLQQI 423
+L K + K +++++ EK++W + E + + E + H L +
Sbjct: 386 QRLRKQEERLRKEEERLQKQEKRLWDQEERLWKKEERLQKQEERLALSQNHKLDKQLAEP 445
Query: 424 QKTKMDLEKYKVQKDLKKLQRKIVELQE 451
Q + DL K K +L++++ ELQE
Sbjct: 446 QCSFEDLNNEK--KSALQLEQQVKELQE 471
>gi|239745153 PREDICTED: similar to Putative golgin subfamily A
member 6-like protein 6 [Homo sapiens]
Length = 655
Score = 51.6 bits (122), Expect = 1e-06
Identities = 50/254 (19%), Positives = 114/254 (44%), Gaps = 19/254 (7%)
Query: 216 RVARCDSSIVKLSGDIHLFRQEHRQIEKAIQEFVPALETLSKNLDMKVMQLLGKIETASS 275
R+ + S ++L+ + E Q+ Q+ + L K L +L ++E
Sbjct: 228 RLVESEKSEIQLNVKDLKRKLERAQLLLPQQQLQVEADRLGKELQSVSAKLQAQVEENEL 287
Query: 276 EQTSNLKMVQGDYRHEMNLLEFKFHSLSSNLYEEVENNKKWTENQFLKYRKDHLGHINEC 335
N + + +R E + E + L + K W + + + +++ + +
Sbjct: 288 WNLLNQQQEEKMWRQEEKIQEQEEKMCEQELKIREQEEKMWRQEEKMHEQEEKIREQEDK 347
Query: 336 LKVLQEKLEKSENKM---EEKLLQLSSKV-ENFINTQKQETQL----SKVKHMENKLSKK 387
+ +EK+ + E K+ EEK+ + K+ E Q+QE ++ K++ E K +K
Sbjct: 348 MWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEK 407
Query: 388 MEQMEKQIWGELETMQNEYQSGFKS----------IHDSLSSLQQIQKTKMDLEKYKVQK 437
M + EK++ + E ++ + + ++ + D L+++++ KM E+ K+Q+
Sbjct: 408 MWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEE-KMQEEEEKMQE 466
Query: 438 DLKKLQRKIVELQE 451
+K+QR+ ++QE
Sbjct: 467 QEEKIQRQEEKIQE 480
Score = 51.2 bits (121), Expect = 2e-06
Identities = 46/226 (20%), Positives = 106/226 (46%), Gaps = 22/226 (9%)
Query: 233 LFRQEHRQIEKAIQEFVPALETLSKNLDMKVMQLLGKIETASSE---QTSNLKMVQGDYR 289
++RQE + E+ +E + E + K+ + KI+ E Q ++ + +
Sbjct: 348 MWRQEEKIREQ--EEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQ 405
Query: 290 HEMNLLEFKFHSLSSNLYEEVENNKKWTENQFLKYRKDHLGHINECLKVLQEKLEKSENK 349
+M E K + E+ E + W + + ++ ++ + E L+ ++EK+++ E K
Sbjct: 406 EKMWRQEKKMREQDEKIREQEE--EMWRQEEKIRELEEMMQDQEEKLREVEEKMQEEEEK 463
Query: 350 MEEKLLQLSSKVENFINTQKQETQLSKVKHMENKL---SKKMEQMEKQIWGELETMQNEY 406
M+E+ ++ + E +++ + K+ E K+ +KM + E+++W + E MQ +
Sbjct: 464 MQEQEEKIQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEKMWEQEEKMQEQE 523
Query: 407 QSGFKSIHDSLSSLQQIQKTKMDLEKYKVQKDLKKLQRKIVELQEV 452
+ Q Q+ KM ++ ++ + +K+Q + V LQE+
Sbjct: 524 EK------------MQRQEEKMREQEVRLWQQEEKMQEQEVRLQEL 557
Score = 29.3 bits (64), Expect = 7.7
Identities = 32/215 (14%), Positives = 94/215 (43%), Gaps = 5/215 (2%)
Query: 149 FRKEESLARKLLESHIQTITSIVKKLSQNIEILEDQIRARDQAATGTNFAVHEINIKHLQ 208
+R+EE + + E I+ + + + I +++I+ +++ + E K +
Sbjct: 349 WRQEEKIREQ--EEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQE 406
Query: 209 GVGDLRGRVARCDSSIVKLSGDIHLFRQEHRQIEKAIQEFVPALETLSKNLDMKVMQLLG 268
+ ++ D I + ++ ++ R++E+ +Q+ L + + + + ++
Sbjct: 407 KMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEEEEKMQE 466
Query: 269 KIETASSEQTSNLKMVQGDYRHEMNLL-EFKFHSLSSNLYEEVENNKKWTENQFLKYRKD 327
+ E ++ + + +R E L E K ++ + E K W + + ++ +++
Sbjct: 467 QEEKIQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEE--KMWEQEEKMQEQEE 524
Query: 328 HLGHINECLKVLQEKLEKSENKMEEKLLQLSSKVE 362
+ E ++ + +L + E KM+E+ ++L E
Sbjct: 525 KMQRQEEKMREQEVRLWQQEEKMQEQEVRLQELEE 559
>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 828
Score = 51.6 bits (122), Expect = 1e-06
Identities = 57/310 (18%), Positives = 134/310 (43%), Gaps = 20/310 (6%)
Query: 157 RKLLESHIQTITSIVKKLSQNIEILEDQIRARDQAATGTNFAVHEINIKHLQGVGDLRGR 216
+K H + + ++ I IL Q + A + A + +L DL GR
Sbjct: 73 KKASHQHQEALRREIEAQDHTIRILTCQKTELETALYYSQDAARKFEDGNLGESKDLAGR 132
Query: 217 VARCDSSIVKLSGDIHLFRQEHRQIEKAIQEFVPALETLS----------KNLDMKVMQL 266
+ +L + H++ ++ I+E + LS + L K +L
Sbjct: 133 LHHSWHFAGELQRALSAVSTWHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAEL 192
Query: 267 LGKIETASSEQTSNLKMVQGDYRHEMNLLEFKFHSLSSNLYEEVENNKKWTENQFLKYRK 326
K+ A SE+ S +++ + + ++ +F + +N +E + W + + L+ ++
Sbjct: 193 QEKLRLAESEK-SEIQLNVKELKRKLERAKFLLPQVQTNTLQE----EMWRQEEELREQE 247
Query: 327 DHLGHINECLKVLQEKLEKSENKMEEKLLQLSSKVENFINTQKQETQLSKVKHMENKLSK 386
+ E + +E+L + E KM E+ ++ + + +K+ + K + KL +
Sbjct: 248 KKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQEKELREQEKELREQKKLRE 307
Query: 387 KMEQMEKQ---IWGELETMQNEYQSGFKSIHDSLSSLQQI--QKTKMDLEKYKVQKDLKK 441
+ EQM++Q +W + E M+ + + ++ +Q+ Q+ KM ++ ++ + ++
Sbjct: 308 QEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDER 367
Query: 442 LQRKIVELQE 451
L+ K ++E
Sbjct: 368 LREKEERMRE 377
Score = 44.7 bits (104), Expect = 2e-04
Identities = 31/142 (21%), Positives = 67/142 (47%), Gaps = 6/142 (4%)
Query: 287 DYRHEMNLLEFKFHSLSSNLYEEVENNKKWTENQFLKYRKDHLGHINECLKVLQEKLEKS 346
+ +M E K ++E+ E +K + + + +++ + E + +EK+ +
Sbjct: 599 EQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQ 658
Query: 347 ENKMEEKLLQLSSKVENFINTQ-KQETQLSKVKHMENKLSKKMEQM---EKQIWGELETM 402
E KM E+ ++ + E + K + Q K++ E K+ + E+M E+++WG+ E M
Sbjct: 659 EEKMREQEEKMQGQEEKMREQEEKMQGQEEKMREQEEKMRGQEEKMWGQEEKMWGQEEKM 718
Query: 403 --QNEYQSGFKSIHDSLSSLQQ 422
Q E + + I D +Q+
Sbjct: 719 WGQEEMREKEERIRDQKEKMQE 740
Score = 40.8 bits (94), Expect = 0.003
Identities = 36/159 (22%), Positives = 69/159 (43%), Gaps = 24/159 (15%)
Query: 311 ENNKKWTENQFLKYRKDHLGHINECLKVLQEKLEKSENKM---EEKLLQ---LSSKVENF 364
E +K E + ++ R+ + E ++ +EK++K E M EEK Q L + E
Sbjct: 383 EQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKL 442
Query: 365 INTQKQETQLSKVKHMENKL---------------SKKMEQMEKQIWGELETMQNEYQSG 409
+K + Q K+ E K+ +KM + E Q+W + E M+++ Q
Sbjct: 443 WEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQ-- 500
Query: 410 FKSIHDSLSSLQQIQKTKMDLEKYKVQKDLKKLQRKIVE 448
K +Q ++ + E+ + QK + + + K+ E
Sbjct: 501 -KMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMRE 538
Score = 37.7 bits (86), Expect = 0.022
Identities = 27/145 (18%), Positives = 69/145 (47%), Gaps = 6/145 (4%)
Query: 311 ENNKKWTENQFLKYRKDHLGHINECLKVLQEKLEKSENKMEEKLLQLSSKVENFINTQ-K 369
E K W + + K R++ E QE+ + E +M E+ ++ + E + K
Sbjct: 525 EQKKMWQQEE--KMREEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEK 582
Query: 370 QETQLSKVKHMENKL---SKKMEQMEKQIWGELETMQNEYQSGFKSIHDSLSSLQQIQKT 426
+ Q K++ E K+ +KM++ E+++W + E M + + + + Q+ +
Sbjct: 583 MQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQ 642
Query: 427 KMDLEKYKVQKDLKKLQRKIVELQE 451
+ + + ++ ++ +++ + K+ E +E
Sbjct: 643 EQEEKMWEQEEKMREQEEKMREQEE 667
Score = 35.0 bits (79), Expect = 0.14
Identities = 76/442 (17%), Positives = 175/442 (39%), Gaps = 58/442 (13%)
Query: 45 VNKSASPTATAEEQPVEPDGPLPGSDNNQEKKVRLSPAKMST-------KNSTDLVEYVD 97
+N +P T E P+ S +QE R A+ T K + Y
Sbjct: 52 INNGTNPETTTSEGCHSPEDEKKASHQHQEALRREIEAQDHTIRILTCQKTELETALYYS 111
Query: 98 KSHAFLPIIPNTQRGQLEDRLNNQARTIAFLLEQAFRIKEDISACLQGTHGFRKE----- 152
+ A + ED +++ +A L ++ ++ L + K+
Sbjct: 112 QDAA----------RKFEDGNLGESKDLAGRLHHSWHFAGELQRALSAVSTWHKKADRYI 161
Query: 153 ESLARKL----LESHIQTITSIVKKLSQNIEILEDQIRARDQAATGTNFAVHEINIKHLQ 208
E L ++ LE + TIT+ ++L + L++++R + + ++N+K L+
Sbjct: 162 EELTKERDALSLELYRNTITN--EELKKKNAELQEKLRLAESEKSEI-----QLNVKELK 214
Query: 209 GVGDLRGRVARCDSSIVKLSGDIHLFRQEHRQIEKAI---QEFVPALETLSKNLDMKVMQ 265
+ R + L ++ +E R+ EK I +E + E + + K+ +
Sbjct: 215 RKLE-RAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMRE 273
Query: 266 LLGKI---ETASSEQTSNLKMVQGDYRHEMNLLEFK--FHSLSSNLYEEVENNKK----- 315
K+ E EQ L+ + + R + L E + ++E+ E ++
Sbjct: 274 QEEKMRRQEKRLREQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKM 333
Query: 316 -------WTENQFLKYRKDHLGHINECLKVLQEKLEKSENKM--EEKLLQLSSKVENFIN 366
W + + ++ ++ + E + E+L + E +M +EK+ + K++
Sbjct: 334 WRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEER 393
Query: 367 TQKQETQLSKVKHMENKLSKKMEQMEKQIW--GELETMQNEYQSGFKSIHDSLSSLQQIQ 424
+++E ++ + + + +KM++ E+ +W E E Q + + + +Q +
Sbjct: 394 IREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEE 453
Query: 425 KTKMDLEKYKVQKDLKKLQRKI 446
K EK + Q+++ ++K+
Sbjct: 454 KIWEQEEKIRDQEEMWGQEKKM 475
Score = 34.7 bits (78), Expect = 0.18
Identities = 27/144 (18%), Positives = 70/144 (48%), Gaps = 10/144 (6%)
Query: 311 ENNKKWTENQFLKYRKDHLGHINECLKVLQEKLEKSENKM---EEKLLQLSSKVENFINT 367
+ K W + + ++ +++ G + + QEK+ + E++M EEK+ K+ +
Sbjct: 451 QEEKIWEQEEKIRDQEEMWGQEKKMWR--QEKMREQEDQMWEQEEKMRDQEQKMWDQEER 508
Query: 368 QKQETQLSKVKHMENKLSKKMEQMEKQIWGELETMQNEYQSGFKSIHDSLSSLQQIQKTK 427
++ + + K + KKM Q E+++ E +T + E K D +++ ++ +
Sbjct: 509 MWEQDERLREKEERMREQKKMWQQEEKMREEKKTQEQE-----KKTWDQEEKMREEERMR 563
Query: 428 MDLEKYKVQKDLKKLQRKIVELQE 451
+K + ++++ + Q + ++ QE
Sbjct: 564 EREKKMREEEEMMREQEEKMQEQE 587
Score = 33.1 bits (74), Expect = 0.53
Identities = 28/164 (17%), Positives = 75/164 (45%), Gaps = 13/164 (7%)
Query: 296 EFKFHSLSSNLYEEVENNKKWTENQFLKYRKDHLGHINECL----KVLQEKLEKSENK-- 349
E K ++++ E + W +++ L+ +++ + + K+ +EK + + K
Sbjct: 492 EEKMRDQEQKMWDQEE--RMWEQDERLREKEERMREQKKMWQQEEKMREEKKTQEQEKKT 549
Query: 350 --MEEKLLQLSSKVENFINTQKQETQLSKVKHMENKLSKKMEQMEKQIWGELETMQNEYQ 407
EEK+ + E +++E + + + + +KM + E+++W + E MQ + +
Sbjct: 550 WDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEE 609
Query: 408 SGFKSIHDSLSSLQQIQKTKMDLEKYKVQKDLKKLQRKIVELQE 451
K +Q ++ KM ++ + + +K+Q + ++ E
Sbjct: 610 ---KMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWE 650
>gi|109659847 filamin A interacting protein 1-like isoform 3 [Homo
sapiens]
Length = 1133
Score = 51.6 bits (122), Expect = 1e-06
Identities = 80/386 (20%), Positives = 162/386 (41%), Gaps = 42/386 (10%)
Query: 70 DNNQEKKVRLSPAKMS-TKNSTDLVEYVDKSHAFLPIIPNTQRGQLEDRLNNQARTIAFL 128
+ QEK+ R++ K TK + + VD+ + QR ++++ N T L
Sbjct: 216 EKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLTAQL-TLQRQKIQELTTNAKETHTKL 274
Query: 129 LEQAFRIKEDISACL--------QGTHGFRKEESLARKLLESHIQTITSIVKKLSQNIEI 180
R++E+ Q T + ++++ KL Q ++L Q +
Sbjct: 275 ALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQN-----RQLQQKLAA 329
Query: 181 LEDQIRARDQAATGTNFAVHEINIKHLQGVGDLRGRVARCDSSIVKLSGDIHLFRQEHRQ 240
L QI ++ A E+ D++ ++++ + + ++ R+
Sbjct: 330 LSRQIDELEETNRSLRKAEEELQ--------DIKEKISKGEYGNAGIMAEVEELRKRVLD 381
Query: 241 IEKAIQEFVPALET---LSKNLDMKVMQLLGKIETASSEQTSNLKMVQGDYRHEMNLLEF 297
+E +E + E L+K L+ + +Q K E+ S M N +
Sbjct: 382 MEGKDEELIKMEEQCRDLNKRLERETLQ--SKDFKLEVEKLSKRIMALEKLEDAFNKSKQ 439
Query: 298 KFHSLSSNLYEEVENNKKWTEN-QFLKYRKDHLGHINECLKVLQEKLEKSENKMEEKLLQ 356
+ +SL NL +E K+ ++ + LK R I E L+ ++ +LEK+E ++E L +
Sbjct: 440 ECYSLKCNLEKERMTTKQLSQELESLKVR------IKE-LEAIESRLEKTEFTLKEDLTK 492
Query: 357 LSSKVENFINTQKQETQLSKVKHMENKL---SKKMEQMEKQIWGELETMQNEYQSGFKSI 413
L + F++ +K T K+K E+KL S +++ + ++ E + E + KS
Sbjct: 493 LKTLTVMFVDERK--TMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSK 550
Query: 414 HDSLSSLQQIQKTKMDLE-KYKVQKD 438
D + + K + DL+ K K +++
Sbjct: 551 TDVEEKMYSVTKERDDLKNKLKAEEE 576
Score = 32.3 bits (72), Expect = 0.90
Identities = 65/308 (21%), Positives = 119/308 (38%), Gaps = 36/308 (11%)
Query: 86 TKNSTDLVEYVDKSHAFLPIIPNTQ------RGQLEDRLNNQARTIAFLLEQ---AFRIK 136
TK T V +VD+ + T+ QL+ N L+E+ A + K
Sbjct: 491 TKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSK 550
Query: 137 EDISACLQGTHGFRKEESLARKLLESHIQTITSIVKKLSQNIEILE----DQIRAR-DQA 191
D+ + R + K E + S V L ++ LE D ++ + +Q
Sbjct: 551 TDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQD 610
Query: 192 ATGTNFAVHEINIKHLQGVGDLRGRVARCDSSIVKLSG---DIHLFRQEHRQIEKAIQEF 248
+ + A+H+ N K + +L V R + + D+ E+ +E+
Sbjct: 611 SGKSTTALHQENNK----IKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLERRYANE 666
Query: 249 VPALETLSKNLDMKVMQLLGKIETASSEQTSNLKMVQGDYRHEMNLLEFKFHSLSSNLYE 308
+ LSK L+ M+L K + A +TS+ + + + E + S +L
Sbjct: 667 RDKAQFLSKELEHVKMEL-AKYKLAEKTETSHEQWLFKRLQEE--------EAKSGHLSR 717
Query: 309 EVENNKKWTENQFLKYRKDHLGHINECLKVLQEKLEKSENKMEEKLLQLSSKVENFINTQ 368
EV+ K+ +D + H+ VLQ+KL + EN+ + L ++EN
Sbjct: 718 EVDALKEKIHEYMAT--EDLICHLQGDHSVLQKKLNQQENRNRD----LGREIENLTKEL 771
Query: 369 KQETQLSK 376
++ SK
Sbjct: 772 ERYRHFSK 779
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.312 0.127 0.338
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 14,684,270
Number of Sequences: 37866
Number of extensions: 632566
Number of successful extensions: 5196
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 81
Number of HSP's successfully gapped in prelim test: 663
Number of HSP's that attempted gapping in prelim test: 3640
Number of HSP's gapped (non-prelim): 1691
length of query: 452
length of database: 18,247,518
effective HSP length: 106
effective length of query: 346
effective length of database: 14,233,722
effective search space: 4924867812
effective search space used: 4924867812
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.