Guide to the Human Genome
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Search of human proteins with 224548936

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|224548936 hypothetical protein LOC100170229 [Homo sapiens]
         (715 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|224548936 hypothetical protein LOC100170229 [Homo sapiens]        1411   0.0  
gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]       219   5e-57
gi|21361282 splicing factor, arginine/serine-rich 4 [Homo sapiens]    175   1e-43
gi|42560244 peptidylprolyl isomerase G [Homo sapiens]                 163   6e-40
gi|153251865 hypothetical protein LOC84226 [Homo sapiens]             158   1e-38
gi|42542379 serine/arginine repetitive matrix 1 [Homo sapiens]        157   2e-38
gi|88501738 TRIO and F-actin binding protein isoform 6 [Homo sap...   155   9e-38
gi|116008442 zinc finger CCCH-type containing 13 [Homo sapiens]       155   2e-37
gi|116089325 splicing factor, arginine/serine-rich 12 isoform a ...   151   2e-36
gi|21040255 splicing factor, arginine/serine-rich 12 isoform b [...   151   2e-36
gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo ...   143   6e-34
gi|166235169 PRP38 pre-mRNA processing factor 38 (yeast) domain ...   141   2e-33
gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]   137   5e-32
gi|50083281 KIAA1853 protein [Homo sapiens]                           125   1e-28
gi|154146223 splicing factor, arginine/serine-rich 130 [Homo sap...   123   5e-28
gi|154146193 splicing factor, arginine/serine-rich 130 [Homo sap...   123   5e-28
gi|158854042 hypothetical protein LOC222183 [Homo sapiens]            120   6e-27
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]    118   2e-26
gi|6631100 natural killer-tumor recognition sequence [Homo sapiens]   117   4e-26
gi|133922600 splicing factor, arginine/serine-rich 16 [Homo sapi...   116   6e-26
gi|38146107 arginine/serine-rich coiled-coil 2 isoform a [Homo s...   110   5e-24
gi|55741709 RNA binding motif protein 25 [Homo sapiens]               108   1e-23
gi|21040326 SON DNA-binding protein isoform F [Homo sapiens]          108   2e-23
gi|21040314 SON DNA-binding protein isoform B [Homo sapiens]          108   2e-23
gi|4759100 splicing factor, arginine/serine-rich 11 [Homo sapiens]    108   2e-23
gi|89276756 serine/threonine-protein kinase PRP4K [Homo sapiens]      105   1e-22
gi|145309302 cell division cycle 2-like 5 isoform 1 [Homo sapiens]    104   2e-22
gi|145309300 cell division cycle 2-like 5 isoform 2 [Homo sapiens]    104   2e-22
gi|239757964 PREDICTED: hypothetical protein [Homo sapiens]           103   4e-22
gi|239747174 PREDICTED: hypothetical protein XP_002343931, parti...   100   5e-21

>gi|224548936 hypothetical protein LOC100170229 [Homo sapiens]
          Length = 715

 Score = 1411 bits (3653), Expect = 0.0
 Identities = 715/715 (100%), Positives = 715/715 (100%)

Query: 1   MSSPKRSSKPSMSLAPSGSSMPTADPKPPASLKSTKSATPNRSLVPTKPATSRNSVMSPS 60
           MSSPKRSSKPSMSLAPSGSSMPTADPKPPASLKSTKSATPNRSLVPTKPATSRNSVMSPS
Sbjct: 1   MSSPKRSSKPSMSLAPSGSSMPTADPKPPASLKSTKSATPNRSLVPTKPATSRNSVMSPS 60

Query: 61  SSKSTKSTSTKRAPSNRPSSRSRVRSKARTPSRVSTDTRTSKASKASDVRCHQRRGTHSR 120
           SSKSTKSTSTKRAPSNRPSSRSRVRSKARTPSRVSTDTRTSKASKASDVRCHQRRGTHSR
Sbjct: 61  SSKSTKSTSTKRAPSNRPSSRSRVRSKARTPSRVSTDTRTSKASKASDVRCHQRRGTHSR 120

Query: 121 GRTPGRRGSRSSKRSPSRASTPGRIRTHGARPGMASRVRTPTSQQKGSRGKSYGRPRTSN 180
           GRTPGRRGSRSSKRSPSRASTPGRIRTHGARPGMASRVRTPTSQQKGSRGKSYGRPRTSN
Sbjct: 121 GRTPGRRGSRSSKRSPSRASTPGRIRTHGARPGMASRVRTPTSQQKGSRGKSYGRPRTSN 180

Query: 181 RERSDSQPRNLSKKSYRPPGGSGIGRSSELAVTPSTAKCQTPTGIPSKEKSDNPSPSSSR 240
           RERSDSQPRNLSKKSYRPPGGSGIGRSSELAVTPSTAKCQTPTGIPSKEKSDNPSPSSSR
Sbjct: 181 RERSDSQPRNLSKKSYRPPGGSGIGRSSELAVTPSTAKCQTPTGIPSKEKSDNPSPSSSR 240

Query: 241 KVKSYGQMIIPSREKSYSPTEMSSRVKSYNQASTRSRPQSHSQSRSPRRSRSGSQKRTHS 300
           KVKSYGQMIIPSREKSYSPTEMSSRVKSYNQASTRSRPQSHSQSRSPRRSRSGSQKRTHS
Sbjct: 241 KVKSYGQMIIPSREKSYSPTEMSSRVKSYNQASTRSRPQSHSQSRSPRRSRSGSQKRTHS 300

Query: 301 RVRSHSWKRNHSRARSRTRKGILSQMGRHSQSRSHSKGKSQNQSRTPRRGRSHNWSRNPS 360
           RVRSHSWKRNHSRARSRTRKGILSQMGRHSQSRSHSKGKSQNQSRTPRRGRSHNWSRNPS
Sbjct: 301 RVRSHSWKRNHSRARSRTRKGILSQMGRHSQSRSHSKGKSQNQSRTPRRGRSHNWSRNPS 360

Query: 361 KERSHSHSRSSSKERDHRGSSSPRKESGRSQSGSPNKQRDHSRSRSPNKARDRSRSRSPY 420
           KERSHSHSRSSSKERDHRGSSSPRKESGRSQSGSPNKQRDHSRSRSPNKARDRSRSRSPY
Sbjct: 361 KERSHSHSRSSSKERDHRGSSSPRKESGRSQSGSPNKQRDHSRSRSPNKARDRSRSRSPY 420

Query: 421 KARDRSRSRSPNKARDCSRSRSPYKARDRSRSRSPNKARDHSRSRSPNKARDRSRSRSPS 480
           KARDRSRSRSPNKARDCSRSRSPYKARDRSRSRSPNKARDHSRSRSPNKARDRSRSRSPS
Sbjct: 421 KARDRSRSRSPNKARDCSRSRSPYKARDRSRSRSPNKARDHSRSRSPNKARDRSRSRSPS 480

Query: 481 KERDHSQLGSPSKERDHRRSRSPSKERQCRQSRSSSKERDHRRSRSPSKERQRRQSRSPN 540
           KERDHSQLGSPSKERDHRRSRSPSKERQCRQSRSSSKERDHRRSRSPSKERQRRQSRSPN
Sbjct: 481 KERDHSQLGSPSKERDHRRSRSPSKERQCRQSRSSSKERDHRRSRSPSKERQRRQSRSPN 540

Query: 541 KERDRSQSRSPSEEREHRQSRSPSKERDRRRWRSPSKERERRQSRSSSEERDHSRSRSPN 600
           KERDRSQSRSPSEEREHRQSRSPSKERDRRRWRSPSKERERRQSRSSSEERDHSRSRSPN
Sbjct: 541 KERDRSQSRSPSEEREHRQSRSPSKERDRRRWRSPSKERERRQSRSSSEERDHSRSRSPN 600

Query: 601 KQSGYSRPRASSKEKAHSRSRTPSKEGNHSQSRTSSKESDPSQSTVPRSPDWKRSPTRTS 660
           KQSGYSRPRASSKEKAHSRSRTPSKEGNHSQSRTSSKESDPSQSTVPRSPDWKRSPTRTS
Sbjct: 601 KQSGYSRPRASSKEKAHSRSRTPSKEGNHSQSRTSSKESDPSQSTVPRSPDWKRSPTRTS 660

Query: 661 SLSQNRTPSKTSSHSPSTFPSGGQTLSQDDSQADATTSKATLPGERSSSSSSKLA 715
           SLSQNRTPSKTSSHSPSTFPSGGQTLSQDDSQADATTSKATLPGERSSSSSSKLA
Sbjct: 661 SLSQNRTPSKTSSHSPSTFPSGGQTLSQDDSQADATTSKATLPGERSSSSSSKLA 715


>gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]
          Length = 2752

 Score =  219 bits (559), Expect = 5e-57
 Identities = 224/744 (30%), Positives = 323/744 (43%), Gaps = 103/744 (13%)

Query: 17   SGSSMPTADPKPPASLKSTKSATPNRSLVPTKPATSRNSVMSPSSSKSTKSTSTKRAPSN 76
            SGSS    D     S  S   ++P    +P  P+  R+   S    K+   T     P +
Sbjct: 1441 SGSSPGLRDGSGTPSRHSLSGSSPGMKDIPRTPSRGRSECDSSPEPKALPQTPR---PRS 1497

Query: 77   RPSSRSRVRSKARTPSRVSTDTRTSKASKA---SDVRCHQRRGTHSR-----GRTPGRRG 128
            R  S   + +K  TP R  + + +S   K    + +    R G+          +P  R 
Sbjct: 1498 RSPSSPELNNKCLTPQRERSGSESSVDQKTVARTPLGQRSRSGSSQELDVKPSASPQERS 1557

Query: 129  -SRSSKRSPSRASTPGRIRTH-GARPGMASRVR-TPTSQQKGSRGKSYGRPRTSNRERSD 185
             S SS  S ++  TP R R+  G+ P + S+ R +P   + GS  +   +PR + R +S 
Sbjct: 1558 ESDSSPDSKAKTRTPLRQRSRSGSSPEVDSKSRLSPRRSRSGSSPEVKDKPRAAPRAQSG 1617

Query: 186  SQ---------PRNLSKKSYRPPGGSGIGRSSELAVTP------------------STAK 218
            S          PR L ++S       G G S E + +                   S+ +
Sbjct: 1618 SDSSPEPKAPAPRALPRRSRSGSSSKGRGPSPEGSSSTESSPEHPPKSRTARRGSRSSPE 1677

Query: 219  CQTPTGIPSKEKSDNPSPSSSRKVKSYGQMIIPSREKSYSPTEMSSRVKSYNQASTRSRP 278
             +T +  P + +S   SP  +RK +   +    SR  S SP   S     + ++ + S P
Sbjct: 1678 PKTKSRTPPRRRSSRSSPELTRKARLSRR----SRSASSSPETRSRTPPRHRRSPSVSSP 1733

Query: 279  QSHSQSRSPRRSRSGSQKRTHSRVRSHSWKRNHSRARSRTRKGILSQMGRHSQSRSHSKG 338
            +   +SRS RR RS S  RT +  R         R+ S   +G+          RS S+ 
Sbjct: 1734 EPAEKSRSSRRRRSASSPRTKTTSR-------RGRSPSPKPRGL---------QRSRSRS 1777

Query: 339  KSQNQSRTPRRGRSHNWSRNPSKERSHSHSRSSSKERDHRGSSSPRKESGRSQSGSPNKQ 398
            + +    T RR RS + S++ S+ R  S SRS    R   GS    +   R +S   + +
Sbjct: 1778 RREKTRTTRRRDRSGS-SQSTSRRRQRSRSRSRVTRRRRGGSGYHSRSPARQESSRTSSR 1836

Query: 399  RDHSRSRSPNKARDRSRSR---SPYK---------ARDRSRSRSPNKARDCSRSR-SPYK 445
            R   RSR+P  +R RSRSR   +P+K            RSRSR+P  +R  SRSR SP  
Sbjct: 1837 RRRGRSRTPPTSRKRSRSRTSPAPWKRSRSRASPATHRRSRSRTPLISRRRSRSRTSPVS 1896

Query: 446  ----------ARDRSRSRSPNKARDHSRSRSPNKARDRSRSRSPSKERDHSQLGSPSKER 495
                       R RSRSR+   +R  SRSR+P   R RSRSR+P+  R  S+  +P   R
Sbjct: 1897 RRRSRSRTSVTRRRSRSRASPVSRRRSRSRTPPVTRRRSRSRTPTTRR-RSRSRTPPVTR 1955

Query: 496  DHRRSRSPSKERQCRQSRSSSKERDHRRSRSPSKERQRRQSRSPNKERDRSQSRSPSEER 555
               RSR+P   R+  +SR+S   R   RSR+    R+R +SR+    R RS+SR+    R
Sbjct: 1956 RRSRSRTPPVTRRRSRSRTSPITRRRSRSRTSPVTRRRSRSRTSPVTRRRSRSRTSPVTR 2015

Query: 556  EHRQSRSPSKERDRRRWRSPSKERERRQSRSSSEERDHSRSRSPNKQSG----------Y 605
               +SR+P   R R R R+P   R+R +SRS    R  SRSR+P    G           
Sbjct: 2016 RRSRSRTPPAIRRRSRSRTPLLPRKRSRSRSPLAIRRRSRSRTPRTARGKRSLTRSPPAI 2075

Query: 606  SRPRASSKEKAHSRSRTPSKEGNHSQSRT------SSKESDPSQSTVPRSP-DWKRSPTR 658
             R  AS      SRS TP    NHS SRT      SS+ S  S+ ++  +P D  RSP  
Sbjct: 2076 RRRSASGSSSDRSRSATPPATRNHSGSRTPPVALNSSRMSCFSRPSMSPTPLDRCRSPGM 2135

Query: 659  TSSLSQNRTPSKTSSHSPSTFPSG 682
               L  +RTP      +  +   G
Sbjct: 2136 LEPLGSSRTPMSVLQQAGGSMMDG 2159



 Score =  219 bits (557), Expect = 9e-57
 Identities = 227/750 (30%), Positives = 346/750 (46%), Gaps = 90/750 (12%)

Query: 17  SGSSMPTADPKPPASLKSTKSATPNRSLVPTKPATSRNSVMSPSSSKSTKSTSTKRAPSN 76
           S SS P  + K  +  K  +S + ++      P        +P S + +K    KR+ S 
Sbjct: 200 SESSSPRRERKKSSKKKKHRSESESKKRKHRSP--------TPKSKRKSKDKKRKRSRST 251

Query: 77  RPSSRSRVRSKARTPSRVSTDTRTSKASKASDVRCHQRRGTHSRGRTP----GRRG---- 128
            P+ +SR   ++ +    S+   +   S+++  + H    T   GR+P    GRRG    
Sbjct: 252 TPAPKSRRAHRSTSADSASSSDTSRSRSRSAAAKTHT---TALAGRSPSPASGRRGEGDA 308

Query: 129 --SRSSKRSPSRASTPGRIRTHGARP--------GMASRVRTPTSQQKGSRGKSYGRPRT 178
             S     S  R S+P       + P           S  R   S ++ S G     P  
Sbjct: 309 PFSEPGTTSTQRPSSPETATKQPSSPYEDKDKDKKEKSATRPSPSPERSSTGPEPPAPTP 368

Query: 179 SNRERSDSQPRNLSKKSYRPPGGSGIGRSSELAVTPSTAKCQTPTGIPSKEKSDNPSPSS 238
              ER    P+ L+     P     +   SE + T   +  ++P  +P    S++  PS 
Sbjct: 369 LLAERHGGSPQPLATT---PLSQEPVNPPSEASPTRDRSPPKSPEKLPQSSSSESSPPSP 425

Query: 239 S-RKVKSYGQMIIPSREKSYSP---TEMSSRVKSYNQASTRS-RPQSHS--------QSR 285
              KV  +      S + + +P    E+SS   S N++  R+ R +SHS        +SR
Sbjct: 426 QPTKVSRHASSSPESPKPAPAPGSHREISSSPTSKNRSHGRAKRDKSHSHTPSRRMGRSR 485

Query: 286 SP---RRSRSGSQ---KRTHSRVRSHSWKRNHS-----RARSRTRKGILSQMGRHSQSRS 334
           SP   +R RS S+   KR HSR RS  W+R+ S     R+RS  R+G      R   SRS
Sbjct: 486 SPATAKRGRSRSRTPTKRGHSRSRSPQWRRSRSAQRWGRSRSPQRRGRSRSPQRPGWSRS 545

Query: 335 HSKGKSQNQSRTPRRGRSHNWSRNPSKERSHSHSRSSSKERDHRGSSSPRKESGRSQSGS 394
            +  + + +SR+ RRGRSH  SR+P+  R  S SR+ ++    R  +  R+   RS+S +
Sbjct: 546 RNTQR-RGRSRSARRGRSH--SRSPAT-RGRSRSRTPARRGRSRSRTPARR---RSRSRT 598

Query: 395 PNKQRDHSRSRSPNKARDRSRSRSPYKARDRSRSRSPNKARDCSRSRSPYKARDRSRSRS 454
           P ++R  SRSR+P + R RSRSR+P  AR RSR+RSP + R  SRSRSP +   RSRSR+
Sbjct: 599 PTRRR--SRSRTPAR-RGRSRSRTP--ARRRSRTRSPVRRR--SRSRSPARRSGRSRSRT 651

Query: 455 PNKARDHSRSRSPNKARDRSRSRSPSKERDHSQLGSPSKERDHRRSRSPSKERQ-----C 509
           P + R  SRSR+P + R RSRSR+P++    S+  +P++ R   RSR+P + R       
Sbjct: 652 PAR-RGRSRSRTPAR-RGRSRSRTPARRSGRSRSRTPAR-RGRSRSRTPRRGRSRSRSLV 708

Query: 510 RQSRSSSKERDHRRSRSPSKERQRRQSRSPNKERDRSQSRSPSEEREHRQSRSPSKERDR 569
           R+ RS S+    R     S ER+ +   S  + R  S           R+SRS S  R +
Sbjct: 709 RRGRSHSRTPQRRGRSGSSSERKNKSRTSQRRSRSNSSPEMKKSRISSRRSRSLSSPRSK 768

Query: 570 RRWRSPSKERERRQSRSSSEERDHSRSRSP--NKQSGYSRPRASSK---EKAHSRSRTPS 624
            + R        R+S S S      +S++P    +SG S+P+A S+    ++ S S  P 
Sbjct: 769 AKSR-----LSLRRSLSGSSPCPKQKSQTPPRRSRSGSSQPKAKSRTPPRRSRSSSSPPP 823

Query: 625 KEGNHSQSRTSSKESDPSQSTVPRSPDWKRSPTRTSSLSQNRTPSKTSSHSPSTFPS-GG 683
           K+ + + SR S   S P       +P  + S T   +  Q+ TP + S    S  P    
Sbjct: 824 KQKSKTPSRQSHSSSSPHPKVKSGTPPRQGSITSPQANEQSVTPQRRSCFESSPDPELKS 883

Query: 684 QTLSQDD-SQADATTSKATLPGERSSSSSS 712
           +T S+   S +     K++ P  +S S SS
Sbjct: 884 RTPSRHSCSGSSPPRVKSSTPPRQSPSRSS 913



 Score =  212 bits (540), Expect = 8e-55
 Identities = 219/732 (29%), Positives = 331/732 (45%), Gaps = 90/732 (12%)

Query: 19  SSMPTADPKPPASL----KSTKSATPNRSLVPTKPATSRNSVMSPSSSKSTKSTSTKRAP 74
           +  P  +P  P SL     S++S TP +     K    R S  S    +  KS+  K+  
Sbjct: 160 AKQPAPEPPKPYSLVRESSSSRSPTPKQKKKKKKKDRGRRSESSSPRRERKKSSKKKKHR 219

Query: 75  SNRPSSRSRVRSKARTPSRVSTDTRTSKASKASDVRCHQRRGTHSRGRTPGRRGSRSSKR 134
           S   S + + RS      R S D +  K S+++      RR   S           S  R
Sbjct: 220 SESESKKRKHRSPTPKSKRKSKDKKR-KRSRSTTPAPKSRRAHRSTSADSASSSDTSRSR 278

Query: 135 SPSRASTPGRIRTHGARPGMASRVRTPTSQQKGSRGKSYGRPRTSNRERSDSQPRNLSKK 194
           S S A+     +TH     +A R  +P S ++G     +  P T++ +R  S P   +K+
Sbjct: 279 SRSAAA-----KTHTT--ALAGRSPSPASGRRGEGDAPFSEPGTTSTQRPSS-PETATKQ 330

Query: 195 SYRPPGGSGIGRSSELAVTPSTAKCQTPTG--------IPSKEKSDNPSPSS----SRKV 242
              P       +  + A  PS +  ++ TG        + ++    +P P +    S++ 
Sbjct: 331 PSSPYEDKDKDKKEKSATRPSPSPERSSTGPEPPAPTPLLAERHGGSPQPLATTPLSQEP 390

Query: 243 KSYGQMIIPSREKSYSPTEMSSRVKSYNQASTRSRPQ----SHSQSRSPRRSRSGSQKRT 298
            +      P+R++S  P       +S +  S+   PQ    S   S SP   +      +
Sbjct: 391 VNPPSEASPTRDRS-PPKSPEKLPQSSSSESSPPSPQPTKVSRHASSSPESPKPAPAPGS 449

Query: 299 HSRVRSHSWKRNHSRARSRTRKGILSQMGRHSQSRSHSKGKSQNQSRTPRRGRSHNWSRN 358
           H  + S    +N S  R++  K        HS + S   G+S++ + T +RGRS   SR 
Sbjct: 450 HREISSSPTSKNRSHGRAKRDKS-------HSHTPSRRMGRSRSPA-TAKRGRSR--SRT 499

Query: 359 PSKERSHSHSRSS----SKERDHRGSSSPRKESGRSQS----GSPNKQRDHSRSRSPNKA 410
           P+K R HS SRS     S+     G S   +  GRS+S    G    +    R RS +  
Sbjct: 500 PTK-RGHSRSRSPQWRRSRSAQRWGRSRSPQRRGRSRSPQRPGWSRSRNTQRRGRSRSAR 558

Query: 411 RDRSRSRSPYKARDRSRSRSPNKARDCSRSRSPYKARDRSRSRSPNKARDHSRSRSPNKA 470
           R RS SRSP   R RSRSR+P + R  SRSR+P  AR RSRSR+P + R  SRSR+P + 
Sbjct: 559 RGRSHSRSP-ATRGRSRSRTPAR-RGRSRSRTP--ARRRSRSRTPTRRR--SRSRTPAR- 611

Query: 471 RDRSRSRSPSKERDHSQLGSPSKERDHRRSRSPSKERQCRQSRSSSKERDHRRSRSPSKE 530
           R RSRSR+P++ R  ++  SP + R   RSRSP++     +SR+ ++ R   RSR+P++ 
Sbjct: 612 RGRSRSRTPARRRSRTR--SPVRRRS--RSRSPARRSGRSRSRTPAR-RGRSRSRTPAR- 665

Query: 531 RQRRQSRSPNKERDRSQSRSPSEEREHRQSRSPSKERDR-----RRWRSPSKERERRQSR 585
           R R +SR+P +   RS+SR+P+  R   +SR+P + R R     RR RS S+  +RR   
Sbjct: 666 RGRSRSRTPARRSGRSRSRTPAR-RGRSRSRTPRRGRSRSRSLVRRGRSHSRTPQRRGRS 724

Query: 586 SSSEERDHSRSRSPNKQSGYSRPRASSKEKAHSRSRTPSKEGNHSQSRTSSKESDPSQST 645
            SS ER +    S  +    S P       +  RSR+ S   + ++SR S + S    S 
Sbjct: 725 GSSSERKNKSRTSQRRSRSNSSPEMKKSRISSRRSRSLSSPRSKAKSRLSLRRSLSGSSP 784

Query: 646 VPRSPDWKRSPTRTSSLS-----QNRTPSKTSSHSPSTFPSGGQTLSQDDSQADATTSKA 700
            P+    +  P R+ S S     ++RTP + S  S S  P                  K+
Sbjct: 785 CPKQKS-QTPPRRSRSGSSQPKAKSRTPPRRSRSSSSPPPK----------------QKS 827

Query: 701 TLPGERSSSSSS 712
             P  +S SSSS
Sbjct: 828 KTPSRQSHSSSS 839



 Score =  190 bits (482), Expect = 5e-48
 Identities = 212/666 (31%), Positives = 298/666 (44%), Gaps = 80/666 (12%)

Query: 2    SSPKRSSK---PSMSLAPSGSSMPTADPKPPASLKSTKSATPNRSLVPTKPATSRNSVMS 58
            SSP   +K   P    + SGSS P  D K   S + ++S +     V  KP  +  +   
Sbjct: 1561 SSPDSKAKTRTPLRQRSRSGSS-PEVDSKSRLSPRRSRSGSSPE--VKDKPRAAPRAQSG 1617

Query: 59   PSSSKSTKSTSTKRAPSNRPSSRSRVRSKARTPSRVSTDTRTSKASKASDVRCHQRRGTH 118
              SS   K+ + +  P     SRS   SK R PS   + +  S        R   RRG+ 
Sbjct: 1618 SDSSPEPKAPAPRALPRR---SRSGSSSKGRGPSPEGSSSTESSPEHPPKSRT-ARRGSR 1673

Query: 119  S------RGRTPGRRGSRSSKRSP--SRASTPGRIRTHGARPGMASRVRTPTSQQKG--- 167
            S      + RTP RR  RSS+ SP  +R +   R R+  A     +R RTP   ++    
Sbjct: 1674 SSPEPKTKSRTPPRR--RSSRSSPELTRKARLSR-RSRSASSSPETRSRTPPRHRRSPSV 1730

Query: 168  SRGKSYGRPRTSNRERSDSQPR--NLSKKSYRP-PGGSGIGRSSELAVTPSTAKCQTPTG 224
            S  +   + R+S R RS S PR    S++   P P   G+ RS       S ++ +    
Sbjct: 1731 SSPEPAEKSRSSRRRRSASSPRTKTTSRRGRSPSPKPRGLQRSR------SRSRREKTRT 1784

Query: 225  IPSKEKSDNPSPSSSRKVKSYGQMIIPSREKSYSPTEMSSRVKSYNQASTRSRPQSHSQS 284
               +++S +   +S R+ +S  +  +  R +  S     SR  +  ++S  S  +   +S
Sbjct: 1785 TRRRDRSGSSQSTSRRRQRSRSRSRVTRRRRGGS--GYHSRSPARQESSRTSSRRRRGRS 1842

Query: 285  RSPRRSRSGSQKRTHSRVRSHSWKRNHSRARSRTRKGILSQMGRHSQSRSHSKGKSQNQS 344
            R+P  SR    KR+ SR     WKR+ SRA   T         R S+SR+    + +++S
Sbjct: 1843 RTPPTSR----KRSRSRTSPAPWKRSRSRASPATH--------RRSRSRTPLISRRRSRS 1890

Query: 345  RTPRRGRSHNWSRNPSKERSHSHSRSSSKERDHRGSSSPRKESGRSQSGSPNKQRDHSRS 404
            RT    R  + SR  S  R  S SR+S   R    S +P     RS+S +P  +R  SRS
Sbjct: 1891 RTSPVSRRRSRSRT-SVTRRRSRSRASPVSRRRSRSRTPPVTRRRSRSRTPTTRR-RSRS 1948

Query: 405  RSPNKARDRSRSRSPYKARDRSRSRSPNKARDCSRSRSPYKARDRSRSRSPNKARDHSRS 464
            R+P   R RSRSR+P   R RSRSR+    R  SRSR+    R RSRSR+    R  SRS
Sbjct: 1949 RTPPVTRRRSRSRTPPVTRRRSRSRTSPITRRRSRSRTSPVTRRRSRSRTSPVTRRRSRS 2008

Query: 465  RSPNKARDRSRSRSPSKERDHSQLGSPSKERDHRRSRSPSKERQCRQSRSSSKERDHRR- 523
            R+    R RSRSR+P   R  S+  +P   R   RSRSP   R+  +SR+    R  R  
Sbjct: 2009 RTSPVTRRRSRSRTPPAIRRRSRSRTPLLPRKRSRSRSPLAIRRRSRSRTPRTARGKRSL 2068

Query: 524  SRSPSKERQRRQSRSPNKERDRSQSRSPSEEREHRQSRSPSKERDRRRWRSPSKERERRQ 583
            +RSP   R+R  S S +   DRS+S +P   R H  SR+P          + +  R    
Sbjct: 2069 TRSPPAIRRRSASGSSS---DRSRSATPPATRNHSGSRTPPV--------ALNSSRMSCF 2117

Query: 584  SRSSSEERDHSRSRSPN--KQSGYSRPRASSKEKA--------------HSRSRTPSKEG 627
            SR S       R RSP   +  G SR   S  ++A              H R+  P    
Sbjct: 2118 SRPSMSPTPLDRCRSPGMLEPLGSSRTPMSVLQQAGGSMMDGPGPRIPDHQRTSVPE--- 2174

Query: 628  NHSQSR 633
            NH+QSR
Sbjct: 2175 NHAQSR 2180



 Score =  183 bits (464), Expect = 6e-46
 Identities = 199/644 (30%), Positives = 290/644 (45%), Gaps = 67/644 (10%)

Query: 57   MSPSSSKSTKSTSTKRAP---------SNRPSSRSRVRSKARTPSRVSTDTRTSKASKAS 107
            M   S++S+  +S++ +P         SN+  S   + +  RTPSR  + + +S   K  
Sbjct: 1371 MKEQSTRSSGHSSSELSPDAVEKAGMSSNQSISSPVLDAVPRTPSRERSSSASSPEMKDG 1430

Query: 108  DVRCHQRRGTHSRGRTPGRRGSRSSKRSPSRASTPGRIRTHGARPGMASRVRTPTSQQK- 166
              R   RR     G +PG R           + TP R    G+ PGM    RTP+  +  
Sbjct: 1431 LPRTPSRRSRS--GSSPGLRDG---------SGTPSRHSLSGSSPGMKDIPRTPSRGRSE 1479

Query: 167  -GSRGKSYGRPRTSN-RERSDSQPRNLSKKSYRPPGGSGIGRSSELAVTPSTAKCQTPTG 224
              S  +    P+T   R RS S P  L+ K   P         SE +V   T   +TP G
Sbjct: 1480 CDSSPEPKALPQTPRPRSRSPSSPE-LNNKCLTPQRERS---GSESSVDQKTV-ARTPLG 1534

Query: 225  IPSKEKSDNP---SPSSSRKVKSYGQMIIPSREKSYSPTEMSSRVKSYNQASTRSRPQSH 281
              S+  S       PS+S + +S       S+ K+ +P    SR        + S P+  
Sbjct: 1535 QRSRSGSSQELDVKPSASPQERSESDSSPDSKAKTRTPLRQRSR--------SGSSPEVD 1586

Query: 282  SQSR-SPRRSRSGSQKRTHSRVRSHSWKRNHSRARSRTRKGILSQMGRHSQSRSHSKGKS 340
            S+SR SPRRSRSGS      + R+    ++ S +    +      + R S+S S SKG+ 
Sbjct: 1587 SKSRLSPRRSRSGSSPEVKDKPRAAPRAQSGSDSSPEPKAPAPRALPRRSRSGSSSKGRG 1646

Query: 341  QNQSRTPRRGRSHNWSRNPSKERSHSHSRSSSKERDHRGSSSPRKESGRSQSGSPNKQRD 400
             +   +     S     +P K R+      SS E   +  + PR+ S RS      K R 
Sbjct: 1647 PSPEGSSSTESS---PEHPPKSRTARRGSRSSPEPKTKSRTPPRRRSSRSSPELTRKARL 1703

Query: 401  HSRSRSPNKARDRSRSRSPYKARDRSRSRSPNKARDCSRSRSPYKARDRSRSRSPNKARD 460
              RSRS + + + +RSR+P + R   RS S +      +SRS  + R  S  R+   +R 
Sbjct: 1704 SRRSRSASSSPE-TRSRTPPRHR---RSPSVSSPEPAEKSRSSRRRRSASSPRTKTTSR- 1758

Query: 461  HSRSRSPN---KARDRSRSRS------PSKERDHSQLGSPSKERDHRRSRSPSKERQCRQ 511
              R RSP+   +   RSRSRS       ++ RD S   S S  R  +RSRS S+  + R+
Sbjct: 1759 --RGRSPSPKPRGLQRSRSRSRREKTRTTRRRDRSG-SSQSTSRRRQRSRSRSRVTRRRR 1815

Query: 512  SRSSSKERDHRRSRSP--SKERQRRQSRSPNKERDRSQSR-SPSEEREHRQSRSPSKERD 568
              S    R   R  S   S  R+R +SR+P   R RS+SR SP+  +  R   SP+  R 
Sbjct: 1816 GGSGYHSRSPARQESSRTSSRRRRGRSRTPPTSRKRSRSRTSPAPWKRSRSRASPATHR- 1874

Query: 569  RRRWRSPSKERERRQSRSSSEERDHSRSRSPNKQSGYSRPRASSKEKAHSRSRTPSKEGN 628
            R R R+P   R R +SR+S   R  SRSR+   +   SR RAS   +  SRSRTP     
Sbjct: 1875 RSRSRTPLISRRRSRSRTSPVSRRRSRSRTSVTRRR-SRSRASPVSRRRSRSRTPPVTRR 1933

Query: 629  HSQSRTSSKESDPSQSTVPRSPDWKRSPTRTSSLSQNRTPSKTS 672
             S+SRT +        T P +   +RS +RT  +++ R+ S+TS
Sbjct: 1934 RSRSRTPTTRRRSRSRTPPVTR--RRSRSRTPPVTRRRSRSRTS 1975



 Score =  166 bits (420), Expect = 7e-41
 Identities = 207/721 (28%), Positives = 323/721 (44%), Gaps = 115/721 (15%)

Query: 16   PSGSSMPTADPKPPASLKSTKSATPNRSLVPTKPAT--SRNSVMSPSSSKSTKSTSTKRA 73
            P   + PT D  PP S +    ++ + S  P+   T  SR++  SP S K   +  + R 
Sbjct: 393  PPSEASPTRDRSPPKSPEKLPQSSSSESSPPSPQPTKVSRHASSSPESPKPAPAPGSHRE 452

Query: 74   PSNRPSSRSRVRSKAR-------TPSRVSTDTRTSKASK--ASDVRCHQRRGTHSRGRTP 124
             S+ P+S++R   +A+       TPSR    +R+   +K   S  R   +RG HSR R+P
Sbjct: 453  ISSSPTSKNRSHGRAKRDKSHSHTPSRRMGRSRSPATAKRGRSRSRTPTKRG-HSRSRSP 511

Query: 125  GRRGSRSSKRSPSRASTPGRIRTHG-ARPGMASRVRTPTSQQKGSRGKSYGRPRTSNRER 183
              R SRS++R     S   R R+    RPG +   R+  +Q++       GR R++ R R
Sbjct: 512  QWRRSRSAQRWGRSRSPQRRGRSRSPQRPGWS---RSRNTQRR-------GRSRSARRGR 561

Query: 184  SDSQ-PRNLSKKSYRPPGGSGIGRSSELAVTPSTAKCQTPTGIPSKEKSDNPSPSSSRKV 242
            S S+ P    +   R P   G  RS     TP+  + ++ T  P++ +S + +P+     
Sbjct: 562  SHSRSPATRGRSRSRTPARRGRSRSR----TPARRRSRSRT--PTRRRSRSRTPARR--- 612

Query: 243  KSYGQMIIPSREKSYSPTEMSSRVKSYNQASTRSRPQSHSQSRSPRRSRSGSQKRTHSRV 302
                      R +S +P    SR        TRS  +  S+SRSP R    S+ RT +R 
Sbjct: 613  ---------GRSRSRTPARRRSR--------TRSPVRRRSRSRSPARRSGRSRSRTPAR- 654

Query: 303  RSHSWKRNHSRARSRTRKGILSQMGRHSQSRSHSKGKSQNQSRTPRRGRSHNWSRNPSKE 362
            R  S  R  +R R R+R    ++    S+SR+ ++ + +++SRTPRRGRS + S      
Sbjct: 655  RGRSRSRTPAR-RGRSRSRTPARRSGRSRSRTPAR-RGRSRSRTPRRGRSRSRS---LVR 709

Query: 363  RSHSHSRSSSKERDHRGSSSPRKESGRSQSGSPNKQRDHSRSRSPNKARDRSRSRSPYKA 422
            R  SHSR+  + R   GSSS RK   R+       QR    + SP   + R  SR   ++
Sbjct: 710  RGRSHSRTPQR-RGRSGSSSERKNKSRT------SQRRSRSNSSPEMKKSRISSR---RS 759

Query: 423  RDRSRSRSPNKAR-DCSRSRSPYKARDRSRSRSPNKARDHSRSRSPNKARDRSRSRSPSK 481
            R  S  RS  K+R    RS S      + +S++P +     RSRS   ++ +++SR+P +
Sbjct: 760  RSLSSPRSKAKSRLSLRRSLSGSSPCPKQKSQTPPR-----RSRS-GSSQPKAKSRTPPR 813

Query: 482  ERDHSQLGSPSKERDHRRSRSPSKERQCRQSRSSSKERDHRRSRSPSKERQRRQSRSPNK 541
             R  S    P K+    +S++PS     RQS SSS      +S +P ++     S   N+
Sbjct: 814  -RSRSSSSPPPKQ----KSKTPS-----RQSHSSSSPHPKVKSGTPPRQGS-ITSPQANE 862

Query: 542  ERDRSQSRSPSEEREHRQSRSPSKERDRRRWRSPSKERERRQSRSSSEERDHSRSRSPNK 601
            +    Q RS  E     + +S +  R      SP + +     R S      SRS SP  
Sbjct: 863  QSVTPQRRSCFESSPDPELKSRTPSRHSCSGSSPPRVKSSTPPRQSP-----SRSSSPQP 917

Query: 602  QSGYSRPRASSKEKAHSRSRTPSKEGNHS-----QSRTSSKESDPSQSTVPR-------S 649
            +    +   S ++++HS S +PS     S     +SR+ S  S+     +PR       S
Sbjct: 918  K---VKAIISPRQRSHSGSSSPSPSRVTSRTTPRRSRSVSPCSNVESRLLPRYSHSGSSS 974

Query: 650  PDWKRSPTRTSSLSQNRTPSKTSSHSPSTFPSGGQTLSQDDSQADATTSKATLPGERSSS 709
            PD K  P           P ++ S S S +P   +  +Q       + SK+  P E+S  
Sbjct: 975  PDTKVKP--------ETPPRQSHSGSISPYP---KVKAQTPPGPSLSGSKSPCPQEKSKD 1023

Query: 710  S 710
            S
Sbjct: 1024 S 1024



 Score =  144 bits (364), Expect = 2e-34
 Identities = 216/795 (27%), Positives = 311/795 (39%), Gaps = 147/795 (18%)

Query: 2    SSPKRSSKPSMS--LAPSGSSMPTADPKP-PASLKSTKSATPNRSLVPTKPATSRNSVMS 58
            +SP R   P  S    P  SS  ++ P P P  +    S++P        P + R    S
Sbjct: 397  ASPTRDRSPPKSPEKLPQSSSSESSPPSPQPTKVSRHASSSPESPKPAPAPGSHREISSS 456

Query: 59   PSSS-----KSTKSTSTKRAPSNR------PSSRSRVRSKARTP-------SRVSTDTRT 100
            P+S      ++ +  S    PS R      P++  R RS++RTP       SR     R+
Sbjct: 457  PTSKNRSHGRAKRDKSHSHTPSRRMGRSRSPATAKRGRSRSRTPTKRGHSRSRSPQWRRS 516

Query: 101  SKASKASDVRCHQRRG---------------THSRGRTPGRRGSRSSKRSPSRASTPGRI 145
              A +    R  QRRG               T  RGR+   R  RS  RSP   +T GR 
Sbjct: 517  RSAQRWGRSRSPQRRGRSRSPQRPGWSRSRNTQRRGRSRSARRGRSHSRSP---ATRGR- 572

Query: 146  RTHGARPGMASRVRTPTSQQKGSRGKSYGRPRTSNRERSDSQPRNLSKKSYRPPGGSGIG 205
                      SR RTP       RG+S  R RT  R RS S+     +   R P   G  
Sbjct: 573  ----------SRSRTP-----ARRGRS--RSRTPARRRSRSRTPTRRRSRSRTPARRGRS 615

Query: 206  RSSELAVTPSTAKCQTPTGIPSKEKSDNPSPSSSRKVKSYGQMIIPSREKSYSPTEMSSR 265
            RS     TP+  + +T + +  + +S +P+  S              R +S +P     R
Sbjct: 616  RSR----TPARRRSRTRSPVRRRSRSRSPARRS-------------GRSRSRTPAR-RGR 657

Query: 266  VKSYNQASTRSRPQSHSQSRSPRRSRSGSQKRTHSRVRSHSWKRNHSRARSRTRKGILSQ 325
             +S   A  R R +S + +R   RSRS +  R   R RS + +R  SR+RS  R+G    
Sbjct: 658  SRSRTPA-RRGRSRSRTPARRSGRSRSRTPAR-RGRSRSRTPRRGRSRSRSLVRRGRSHS 715

Query: 326  MGRHSQSRSHSKGKSQNQSRTPRRGRSHNWSRNPSKER-SHSHSRSSSKERDHRGS--SS 382
                 + RS S  + +N+SRT +R    N S    K R S   SRS S  R    S  S 
Sbjct: 716  RTPQRRGRSGSSSERKNKSRTSQRRSRSNSSPEMKKSRISSRRSRSLSSPRSKAKSRLSL 775

Query: 383  PRKESGRSQSGSPNKQRDHSRSRSPNKARDRSRSRSPYKARDRSRSRSPNKARDCSRSRS 442
             R  SG S       Q    RSRS   ++ +++SR+P + R RS S  P K     +S++
Sbjct: 776  RRSLSGSSPCPKQKSQTPPRRSRS-GSSQPKAKSRTPPR-RSRSSSSPPPK----QKSKT 829

Query: 443  PYKARDRSRSRSPNKARDHSRSRSPNKARDRSRSRSPSKERDHSQLGSPSKERDHRRSRS 502
            P +    S S  P K +  +  R  +    ++  +S + +R      SP  E    +SR+
Sbjct: 830  PSRQSHSSSSPHP-KVKSGTPPRQGSITSPQANEQSVTPQRRSCFESSPDPE---LKSRT 885

Query: 503  PSKERQCRQSRSSSKERDHRRSRSPSKERQRRQSRSPN-------KERDRSQSRSPSEER 555
            PS     R S S S     + S  P +   R  S  P        ++R  S S SPS  R
Sbjct: 886  PS-----RHSCSGSSPPRVKSSTPPRQSPSRSSSPQPKVKAIISPRQRSHSGSSSPSPSR 940

Query: 556  -----EHRQSRSPS-----KERDRRRW-RSPSKERERRQSRSSSEERDHSRSRSPNKQ-- 602
                   R+SRS S     + R   R+  S S   + +    +   + HS S SP  +  
Sbjct: 941  VTSRTTPRRSRSVSPCSNVESRLLPRYSHSGSSSPDTKVKPETPPRQSHSGSISPYPKVK 1000

Query: 603  ---------SGYSRPRASSKEK--------------AHSRSRTPSKEGNHSQSRTSSKES 639
                     SG   P    K K              A  +S TP  E     S    K  
Sbjct: 1001 AQTPPGPSLSGSKSPCPQEKSKDSLVQSCPGSLSLCAGVKSSTPPGESYFGVSSLQLKGQ 1060

Query: 640  DPSQSTVPRSPDWKRSPTRTSSLSQNRTPSKTSSHSPSTFPSGGQTLSQDDSQADATTSK 699
              +      SPD  RS T +  + Q+ + S +      T P GG+  S+  S      S+
Sbjct: 1061 SQT------SPD-HRSDTSSPEVRQSHSESPSLQSKSQTSPKGGR--SRSSSPVTELASR 1111

Query: 700  ATLPGERSSSSSSKL 714
            + +  +R   S+S +
Sbjct: 1112 SPIRQDRGEFSASPM 1126



 Score =  131 bits (329), Expect = 2e-30
 Identities = 190/727 (26%), Positives = 283/727 (38%), Gaps = 120/727 (16%)

Query: 20   SMPTADPKPPASLKSTKSATPNRSLVPTKPATSRNSVMSPSSSKSTKSTSTKRAPSNRPS 79
            S P  + +P  SL   +S +   SL   +  +  +S   P  S   K  S      N   
Sbjct: 1270 SSPEVEERPAVSLTLDQSQS-QASLEAVEVPSMASSWGGPHFSPEHKELSNSPLRENSFG 1328

Query: 80   SRSRVRSKARTPSRVSTDTRTSKASKASDVRCHQRRGTHS---RGRTPGRRGSRSSKRSP 136
            S    R+     + ++T   +      +    +Q     S   + ++    G  SS+ SP
Sbjct: 1329 SPLEFRNSGPLGTEMNTGFSSEVKEDLNGPFLNQLETDPSLDMKEQSTRSSGHSSSELSP 1388

Query: 137  SRASTPGRIRTHG-ARPGMASRVRTPTSQQKGSRGKSY---GRPRT-SNRERSDSQPRNL 191
                  G       + P + +  RTP+ ++  S        G PRT S R RS S P  L
Sbjct: 1389 DAVEKAGMSSNQSISSPVLDAVPRTPSRERSSSASSPEMKDGLPRTPSRRSRSGSSP-GL 1447

Query: 192  SKKSYRPPGGSGIGRSSELAVTPSTAKCQTPTGIPSKEKSDNPSPSSSRKVKSYGQMIIP 251
               S  P   S  G S  +   P T         PS+ +S+     SS + K+  Q    
Sbjct: 1448 RDGSGTPSRHSLSGSSPGMKDIPRT---------PSRGRSEC---DSSPEPKALPQT--- 1492

Query: 252  SREKSYSPTEMSSRVKSYNQASTRSRPQSHSQSRSPRRSRSGSQKRTHSRVRSHSWKRNH 311
             R +S SP                S P+ +++  +P+R RSGS+     +  + +     
Sbjct: 1493 PRPRSRSP----------------SSPELNNKCLTPQRERSGSESSVDQKTVARTPLGQR 1536

Query: 312  SRARSRTRKGILSQMGRHSQSRSHSKGKSQNQSRTPRRGRSHNWSRNPSKERSHSHSRSS 371
            SR+ S     +        +S S S   S+ ++RTP R RS +                S
Sbjct: 1537 SRSGSSQELDVKPSASPQERSESDSSPDSKAKTRTPLRQRSRS---------------GS 1581

Query: 372  SKERDHRGSSSPRKESGRSQSGSPNKQRDHSRSRSPNKARDRSRSRSPYKARDRSRSRSP 431
            S E D +   SPR+    S     +K R   R++S + +    ++ +P     RSRS S 
Sbjct: 1582 SPEVDSKSRLSPRRSRSGSSPEVKDKPRAAPRAQSGSDSSPEPKAPAPRALPRRSRSGSS 1641

Query: 432  NKARDCSRSRSPYKARDRSRSRSPNKARDHSRSRSPNKARDRSRSRSPSKERDHSQLGSP 491
            +K R  S   S   +   S    P K+R  +R  S +    +++SR+P + R  S   SP
Sbjct: 1642 SKGRGPSPEGS---SSTESSPEHPPKSRT-ARRGSRSSPEPKTKSRTPPRRR--SSRSSP 1695

Query: 492  S---KERDHRRSRSPSKERQCR--------QSRSSSKERDHRRSRSP------------- 527
                K R  RRSRS S   + R        +S S S      +SRS              
Sbjct: 1696 ELTRKARLSRRSRSASSSPETRSRTPPRHRRSPSVSSPEPAEKSRSSRRRRSASSPRTKT 1755

Query: 528  -----------------SKERQRRQSRSPNKERDRSQSRSPSEEREHRQSRSPSKERDRR 570
                             S+ R RR+     + RDRS S S S  R  ++SRS S+   RR
Sbjct: 1756 TSRRGRSPSPKPRGLQRSRSRSRREKTRTTRRRDRSGS-SQSTSRRRQRSRSRSRVTRRR 1814

Query: 571  RW------RSPSKE--------RERRQSRSSSEERDHSRSRSPNKQSGYSRPRASSKEKA 616
            R       RSP+++        R R +SR+    R  SRSR+       SR RAS     
Sbjct: 1815 RGGSGYHSRSPARQESSRTSSRRRRGRSRTPPTSRKRSRSRTSPAPWKRSRSRASPATHR 1874

Query: 617  HSRSRTPSKEGNHSQSRTS--SKESDPSQSTVPRSPDWKRSPTRTSSLSQNRTPSKTSSH 674
             SRSRTP      S+SRTS  S+    S+++V R     R+   +   S++RTP  T   
Sbjct: 1875 RSRSRTPLISRRRSRSRTSPVSRRRSRSRTSVTRRRSRSRASPVSRRRSRSRTPPVTRRR 1934

Query: 675  SPSTFPS 681
            S S  P+
Sbjct: 1935 SRSRTPT 1941



 Score =  130 bits (327), Expect = 4e-30
 Identities = 222/820 (27%), Positives = 320/820 (39%), Gaps = 137/820 (16%)

Query: 5    KRSSKPSMSLAPS-GSSMPTADPKP--------PASLKSTKSATPNRSLVPTKPATSRNS 55
            K    P  S   S  SS PT D            A  K   +  P      + P      
Sbjct: 1128 KSGMSPEQSRFQSDSSSYPTVDSNSLLGQSRLETAESKEKMALPPQEDATASPPRQKDKF 1187

Query: 56   VMSPSSSKSTKSTSTKRAPSNRPSSRSRVRSKARTPSRVSTDTRTSKASKASDVRCHQRR 115
               P   +   S   K      P  RS   S   T  + S    +S+  +  +V     +
Sbjct: 1188 SPFPVQDRPESSLVFKDTLRTPPRERSGAGSSPETKEQNSALPTSSQDEELMEV---VEK 1244

Query: 116  GTHSRGRTPGRRGSRSSKRSPSRASTPGRIRTHGARPGMASRVRTPTSQ------QKGSR 169
                 G+      S   + S S   +   +     RP ++  +    SQ      +  S 
Sbjct: 1245 SEEPAGQILSHLSSELKEMSTSNFESSPEVEE---RPAVSLTLDQSQSQASLEAVEVPSM 1301

Query: 170  GKSYGRPRTS--NRERSDSQPRNLSKKS---YRPPGGSGI----GRSSELAVT---PSTA 217
              S+G P  S  ++E S+S  R  S  S   +R  G  G     G SSE+      P   
Sbjct: 1302 ASSWGGPHFSPEHKELSNSPLRENSFGSPLEFRNSGPLGTEMNTGFSSEVKEDLNGPFLN 1361

Query: 218  KCQTPTGIPSKEKSDNPSPSSSRKVK---------SYGQMI----------IPSREKSYS 258
            + +T   +  KE+S   S  SS ++          S  Q I           PSRE+S S
Sbjct: 1362 QLETDPSLDMKEQSTRSSGHSSSELSPDAVEKAGMSSNQSISSPVLDAVPRTPSRERSSS 1421

Query: 259  PTEMSSRVKSYNQASTRSR----PQSHSQSRSP-RRSRSGSQKRTHSRVRSHSWKRNHSR 313
             +    +       S RSR    P     S +P R S SGS        R+ S  R  S 
Sbjct: 1422 ASSPEMKDGLPRTPSRRSRSGSSPGLRDGSGTPSRHSLSGSSPGMKDIPRTPS--RGRSE 1479

Query: 314  ARSRTRKGILSQMGRHSQSRSHSKGKSQNQSRTPRRGRSHNWS--------RNPSKERSH 365
              S      L Q  R  +SRS S  +  N+  TP+R RS + S        R P  +RS 
Sbjct: 1480 CDSSPEPKALPQTPR-PRSRSPSSPELNNKCLTPQRERSGSESSVDQKTVARTPLGQRSR 1538

Query: 366  SHSRSSSKERDHRGSSSPRKESGRSQSGSPNKQRDHSRSRSPNKARDRSRSRSPYKARDR 425
            S    SS+E D + S+SP++ S      SP+ +   +++R+P   R RSRS S  +   +
Sbjct: 1539 S---GSSQELDVKPSASPQERS--ESDSSPDSK---AKTRTP--LRQRSRSGSSPEVDSK 1588

Query: 426  SRSRSPNKARDCSRSRSPYKARDRSRSRSPNKARDHSRSRSPNKARDRSRSRSPSKERDH 485
            SR  SP ++R  S      K R   R++S + +    ++ +P     RSRS S SK R  
Sbjct: 1589 SRL-SPRRSRSGSSPEVKDKPRAAPRAQSGSDSSPEPKAPAPRALPRRSRSGSSSKGRGP 1647

Query: 486  SQLGS---------PSKERDHRR-----------SRSPSKERQCRQSRS-SSKERDHRRS 524
            S  GS         P K R  RR           SR+P + R  R S   + K R  RRS
Sbjct: 1648 SPEGSSSTESSPEHPPKSRTARRGSRSSPEPKTKSRTPPRRRSSRSSPELTRKARLSRRS 1707

Query: 525  RSPSKERQRRQSRSPNKERDRS-QSRSPSEE----REHRQSRSPSKERDRRRWRSPSKER 579
            RS S   + R    P   R  S  S  P+E+    R  R + SP  +   RR RSPS + 
Sbjct: 1708 RSASSSPETRSRTPPRHRRSPSVSSPEPAEKSRSSRRRRSASSPRTKTTSRRGRSPSPKP 1767

Query: 580  ---ERRQSRSSSEERDHSRSRSPNKQSGYSRPRASSKEKAHSRSRTPSK----EGNHSQ- 631
               +R +SRS  E+   +R R    +SG S+  +  ++++ SRSR   +     G HS+ 
Sbjct: 1768 RGLQRSRSRSRREKTRTTRRRD---RSGSSQSTSRRRQRSRSRSRVTRRRRGGSGYHSRS 1824

Query: 632  ------SRTSSKESDPSQSTVPRS----------PDWKRSPTRTSSLSQNRTPSKTSSHS 675
                  SRTSS+       T P S            WKRS +R S  +  R+ S+T   S
Sbjct: 1825 PARQESSRTSSRRRRGRSRTPPTSRKRSRSRTSPAPWKRSRSRASPATHRRSRSRTPLIS 1884

Query: 676  PSTFPSGGQTLSQDDSQADATTSKATLPGERSSSSSSKLA 715
                 S    +S+  S+     S+ ++   RS S +S ++
Sbjct: 1885 RRRSRSRTSPVSRRRSR-----SRTSVTRRRSRSRASPVS 1919



 Score =  129 bits (323), Expect = 1e-29
 Identities = 154/539 (28%), Positives = 230/539 (42%), Gaps = 95/539 (17%)

Query: 251 PSREKSYSPTEMSSRVKSYNQASTRSRPQS----HSQSRSPRRSRSGSQKRTHSRVRSHS 306
           P   K YS    SS  +S      + + +      S+S SPRR R  S K+   R  S S
Sbjct: 165 PEPPKPYSLVRESSSSRSPTPKQKKKKKKKDRGRRSESSSPRRERKKSSKKKKHRSESES 224

Query: 307 WKRNHSRARSRTRKGILSQMGRHSQSRSHSKGKSQNQSRTP-----RRGRSHNWSRNPSK 361
            KR H   RS T K         S+ +S  K + +++S TP     R  RS +     S 
Sbjct: 225 KKRKH---RSPTPK---------SKRKSKDKKRKRSRSTTPAPKSRRAHRSTSADSASSS 272

Query: 362 ERSHSHSRSSSKERDHRGSS--SPRKESGRSQSG-SPNKQRDHSRSRSPNKARDRSRS-R 417
           + S S SRS++ +      +  SP   SGR   G +P  +   + ++ P+     ++   
Sbjct: 273 DTSRSRSRSAAAKTHTTALAGRSPSPASGRRGEGDAPFSEPGTTSTQRPSSPETATKQPS 332

Query: 418 SPYKARDRSR--------SRSPNKARDCSRSRSPYKARDRSRSRSPNKARDHSRSRSP-- 467
           SPY+ +D+ +        S SP ++       +P          SP        S+ P  
Sbjct: 333 SPYEDKDKDKKEKSATRPSPSPERSSTGPEPPAPTPLLAERHGGSPQPLATTPLSQEPVN 392

Query: 468 -----NKARDRSRSRSPSKERDHSQLGS------PSKERDHRRSR--------SPSKERQ 508
                +  RDRS  +SP K    S   S      P+K   H  S         +P   R+
Sbjct: 393 PPSEASPTRDRSPPKSPEKLPQSSSSESSPPSPQPTKVSRHASSSPESPKPAPAPGSHRE 452

Query: 509 CRQSRSSSKERDHRR-----SRSPSKERQRRQSRSP-NKERDRSQSRSPSEEREHRQSRS 562
              S  +SK R H R     S S +  R+  +SRSP   +R RS+SR+P++ R H +SRS
Sbjct: 453 ISSS-PTSKNRSHGRAKRDKSHSHTPSRRMGRSRSPATAKRGRSRSRTPTK-RGHSRSRS 510

Query: 563 PSKERDR------------RRWRSPSKER--------ERRQSRSSSEERDHSRSRSPNKQ 602
           P   R R            RR RS S +R         +R+ RS S  R  S SRSP  +
Sbjct: 511 PQWRRSRSAQRWGRSRSPQRRGRSRSPQRPGWSRSRNTQRRGRSRSARRGRSHSRSPATR 570

Query: 603 SGYSRPRASSKEKAHSRSRTPSKEGNHSQSRTSSKESDPSQSTVPRSPDWKRSPTRTSS- 661
            G SR R  ++ +  SRSRTP++    S+SRT ++    S++   R     R+P R  S 
Sbjct: 571 -GRSRSRTPAR-RGRSRSRTPAR--RRSRSRTPTRRRSRSRTPARRGRSRSRTPARRRSR 626

Query: 662 -------LSQNRTPSKTSSHSPSTFPSGGQTLSQDDSQADATTSKATLPGERSSSSSSK 713
                   S++R+P++ S  S S  P+  +  S+  + A    S++  P  RS  S S+
Sbjct: 627 TRSPVRRRSRSRSPARRSGRSRSRTPA-RRGRSRSRTPARRGRSRSRTPARRSGRSRSR 684



 Score =  106 bits (264), Expect = 9e-23
 Identities = 188/773 (24%), Positives = 282/773 (36%), Gaps = 103/773 (13%)

Query: 13   SLAPSGSSMPTADPKPPASLKSTKSATPNRSLVPTKPATSRNSVMSPSSSKSTKSTSTKR 72
            SL   G S  + D +   S    + +      + +K  TS     S SSS  T+  S   
Sbjct: 1054 SLQLKGQSQTSPDHRSDTSSPEVRQSHSESPSLQSKSQTSPKGGRSRSSSPVTELASRSP 1113

Query: 73   APSNRPS-SRSRVRSKARTP--SRVSTDTRTSKASKASDVRCHQRRGTHSRGRTPGRRGS 129
               +R   S S +     +P  SR  +D+ +     ++ +    R  T            
Sbjct: 1114 IRQDRGEFSASPMLKSGMSPEQSRFQSDSSSYPTVDSNSLLGQSRLETAESKEKMALPPQ 1173

Query: 130  RSSKRSPSRASTPGRIRTHGARPGMA----SRVRTPTSQQKGSRGKSYGRPRTSNRERS- 184
              +  SP R            RP  +      +RTP  ++ G+      + + S    S 
Sbjct: 1174 EDATASPPRQKDKFSPFPVQDRPESSLVFKDTLRTPPRERSGAGSSPETKEQNSALPTSS 1233

Query: 185  -DSQPRNLSKKSYRPPGGSGIGRSSELAVTPSTAKCQTPTGIPSKEKSDNPSPS----SS 239
             D +   + +KS  P G      SSEL    ST+  ++     S E  + P+ S     S
Sbjct: 1234 QDEELMEVVEKSEEPAGQILSHLSSELKEM-STSNFES-----SPEVEERPAVSLTLDQS 1287

Query: 240  RKVKSYGQMIIPSREKSYSPTEMSSRVKSYNQASTRSRPQSHSQSRSPRRSRSGSQKRTH 299
            +   S   + +PS   S+     S   K  + +     P   +   SP   R+     T 
Sbjct: 1288 QSQASLEAVEVPSMASSWGGPHFSPEHKELSNS-----PLRENSFGSPLEFRNSGPLGTE 1342

Query: 300  SRVRSHSWKRNHSRARSRTRKGILSQMGRHSQSRSHSKGKSQNQ---SRTPRRGRSHNWS 356
                  S  +         +      +    QS + S G S ++       + G S N S
Sbjct: 1343 MNTGFSSEVKEDLNGPFLNQLETDPSLDMKEQS-TRSSGHSSSELSPDAVEKAGMSSNQS 1401

Query: 357  ----------RNPSKERSHSHSRSSSKERDHRGSSSPRKESGRSQSGSPNKQRD------ 400
                      R PS+ERS S S    K+        PR  S RS+SGS    RD      
Sbjct: 1402 ISSPVLDAVPRTPSRERSSSASSPEMKD------GLPRTPSRRSRSGSSPGLRDGSGTPS 1455

Query: 401  -HSRS----------RSPNKARD---------------RSRSRSPYKARDRSRSRSPNKA 434
             HS S          R+P++ R                R RSRSP      ++  +P + 
Sbjct: 1456 RHSLSGSSPGMKDIPRTPSRGRSECDSSPEPKALPQTPRPRSRSPSSPELNNKCLTPQRE 1515

Query: 435  RDCSRS--------RSPYKARDRSRSRSP----NKARDHSRSRSPNKARDRSRSRSPSKE 482
            R  S S        R+P   R RS S         A    RS S +    ++++R+P ++
Sbjct: 1516 RSGSESSVDQKTVARTPLGQRSRSGSSQELDVKPSASPQERSESDSSPDSKAKTRTPLRQ 1575

Query: 483  RDHSQLGSPSKERDHRRSRSPSKERQCRQSRSSSKERDHRRSRSPSKERQRRQSRSPNKE 542
            R  S     S E D +   SP + R         K R   R++S S      ++ +P   
Sbjct: 1576 RSRS---GSSPEVDSKSRLSPRRSRSGSSPEVKDKPRAAPRAQSGSDSSPEPKAPAPRAL 1632

Query: 543  RDRSQSRSPSEEREHRQSRSPSKERDRRRWRSPSKERERRQSRSSSEERDHSRSRSPNKQ 602
              RS+S S S+ R      S S E        P     RR SRSS E +  SR+  P ++
Sbjct: 1633 PRRSRSGSSSKGRGPSPEGSSSTESSPEH--PPKSRTARRGSRSSPEPKTKSRT-PPRRR 1689

Query: 603  SGYSRPRASSKEKAHSRSRTPSKEGNHSQSRTSSKESDPSQSTVPRSPDWKRSPTRTSSL 662
            S  S P  + K +   RSR+ S     ++SRT  +       + P   +  RS  R  S 
Sbjct: 1690 SSRSSPELTRKARLSRRSRSASSSPE-TRSRTPPRHRRSPSVSSPEPAEKSRSSRRRRSA 1748

Query: 663  SQNRTPSKTSSH---SPSTFPSGGQTLSQDDSQADATTSKATLPGERSSSSSS 712
            S  RT  KT+S    SPS  P G   L +  S++    ++ T   +RS SS S
Sbjct: 1749 SSPRT--KTTSRRGRSPSPKPRG---LQRSRSRSRREKTRTTRRRDRSGSSQS 1796



 Score = 99.8 bits (247), Expect = 8e-21
 Identities = 204/846 (24%), Positives = 305/846 (36%), Gaps = 180/846 (21%)

Query: 6    RSSKPSMSLAPSGSSMPTADPK-----PPASLKSTKSATP----NRSLVPTKPAT----- 51
            RS  P ++   S S  PT   +     PP + + ++S TP     RS   T P T     
Sbjct: 1924 RSRTPPVTRRRSRSRTPTTRRRSRSRTPPVTRRRSRSRTPPVTRRRSRSRTSPITRRRSR 1983

Query: 52   SRNSVMSPSSSKSTKSTSTKRAPSNRPSSRSRVRSKARTP------SRVSTDTRTSKASK 105
            SR S ++   S+S  S  T+R   +R S  +R RS++RTP      SR  T     K S+
Sbjct: 1984 SRTSPVTRRRSRSRTSPVTRRRSRSRTSPVTRRRSRSRTPPAIRRRSRSRTPLLPRKRSR 2043

Query: 106  ASDVRCHQRRGTHSRGRTPGR-RGSRSSKRSP---------------SRASTPGRIRTH- 148
            +      +RR   SR RTP   RG RS  RSP               SR++TP   R H 
Sbjct: 2044 SRSPLAIRRR---SRSRTPRTARGKRSLTRSPPAIRRRSASGSSSDRSRSATPPATRNHS 2100

Query: 149  GAR-----------------------------PGMASRV---RTPTS--QQKGSRGKSYG 174
            G+R                             PGM   +   RTP S  QQ G       
Sbjct: 2101 GSRTPPVALNSSRMSCFSRPSMSPTPLDRCRSPGMLEPLGSSRTPMSVLQQAGGSMMDGP 2160

Query: 175  RPRTSNRERSDSQPRNLSKKSYR-------------PPGGSGIGRSSELAVTPSTAKCQT 221
             PR  + +R+ S P N ++                 PP  S  G ++ ++  P+      
Sbjct: 2161 GPRIPDHQRT-SVPENHAQSRIALALTAISLGTARPPPSMSAAGLAARMSQVPA------ 2213

Query: 222  PTGIPSKEKSDNPSPSSSRKVKSYGQMIIPSREKSYSPTEMSSRVKSYNQASTRSRPQSH 281
            P  + S   +   + +S     S   M + S      PT +       N A +R+   + 
Sbjct: 2214 PVPLMSLRTAPAANLASRIPAASAAAMNLASARTPAIPTAV-------NLADSRTPAAAA 2266

Query: 282  SQS-RSPRRSRSGSQKRTHSRVRSHSWKRNHSRARSRTRKGILSQMGRHSQSRSHSKGKS 340
            + +  SPR + + S           +   N + AR+      LS  G  +   + +   S
Sbjct: 2267 AMNLASPRTAVAPSAVNLADPRTPTAPAVNLAGARTPAALAALSLTGSGTPPTAANYPSS 2326

Query: 341  QNQSRTPRRGRSHNWSRNPSKERSHSHSRSSSKERDHRGSSSPRKESGRSQSGSPNKQRD 400
               SRTP+   S N     S     +H+ +       R +++    S  S   +P     
Sbjct: 2327 ---SRTPQAPASANLVGPRS-----AHATAPVNIAGSRTAAALAPASLTSARMAPALSGA 2378

Query: 401  HSRS-RSPNKARDRSRSRSPYKARDRSRSRSPNKARDCSRSRSPYKARDRSR-SRSPNK- 457
            +  S R P  A +R   R+     DR+RSR+P  A   SR  S       SR  ++P++ 
Sbjct: 2379 NLTSPRVPLSAYERVSGRTSPPLLDRARSRTPPSAPSQSRMTSERAPSPSSRMGQAPSQS 2438

Query: 458  ----ARDHSRSRSPNKARDRSR-----------SRS----------------------PS 480
                A+D  RS  P+   D+SR           S+S                      P+
Sbjct: 2439 LLPPAQDQPRSPVPSAFSDQSRCLIAQTTPVAGSQSLSSGAVATTTSSAGDHNGMLSVPA 2498

Query: 481  KERDHSQLGSPSKE---------------RDHRRSRSPSKERQCRQSRSSSKERDHRRSR 525
                HS +G P                  ++ R S S S       S SSS         
Sbjct: 2499 PGVPHSDVGEPPASTGAQQPSALAALQPAKERRSSSSSSSSSSSSSSSSSSSSSSSSSGS 2558

Query: 526  SPSKERQRRQSRSPNKERDRSQSRSPSEEREHRQSRSPSKERDRRRWRSPSKERERRQSR 585
            S S          P     R  S +P+ +   R+ R P     +R+ RS S       S 
Sbjct: 2559 SSSDSEGSSLPVQPEVALKRVPSPTPAPKEAVREGRPPEPTPAKRKRRSSSS-----SSS 2613

Query: 586  SSSEERDHSRSRSPNKQSGYSRPRASSKEKAHSRSRTPSKEGNHSQSRTSSKESDPSQST 645
            SSS     S S S +  S  S   +SS   + S S +P+K G  +  + +S +  P    
Sbjct: 2614 SSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSPSPAKPGPQALPKPASPKKPPPGER 2673

Query: 646  VPRSPDWKRSPTRTSSLSQNRTPSKTSSHSPSTFPSGGQTLSQDDSQADATTSKATLPGE 705
              RSP   R P  +   S++ + S      PS  PS          Q  +++ + +  G+
Sbjct: 2674 RSRSP---RKPIDSLRDSRSLSYSPVERRRPSPQPS-------PRDQQSSSSERGSRRGQ 2723

Query: 706  RSSSSS 711
            R  S S
Sbjct: 2724 RGDSRS 2729



 Score = 83.6 bits (205), Expect = 6e-16
 Identities = 155/612 (25%), Positives = 238/612 (38%), Gaps = 58/612 (9%)

Query: 2    SSPKRSSKPSMSLAPSGSSMPTADPKPPAS-------LKSTKSATPNRSLVPTKPATSRN 54
            S P+  ++  ++LA +  S+ TA P P  S       +    +  P  SL  T PA +  
Sbjct: 2171 SVPENHAQSRIALALTAISLGTARPPPSMSAAGLAARMSQVPAPVPLMSL-RTAPAANLA 2229

Query: 55   SVMSPSSSKSTKSTSTKRAPS-----NRPSSRSRVRSKARTPSRVSTDTRTSKASKASDV 109
            S + P++S +  + ++ R P+     N   SR+   + A   +   T    S  + A D 
Sbjct: 2230 SRI-PAASAAAMNLASARTPAIPTAVNLADSRTPAAAAAMNLASPRTAVAPSAVNLA-DP 2287

Query: 110  RCHQRRGTHSRG-RTPGRRGSRS---SKRSPSRASTPGRIRTHGARP-----GMASRVRT 160
            R       +  G RTP    + S   S   P+ A+ P   RT  A       G  S   T
Sbjct: 2288 RTPTAPAVNLAGARTPAALAALSLTGSGTPPTAANYPSSSRTPQAPASANLVGPRSAHAT 2347

Query: 161  PTSQQKGSRGKSYGRPRTSNRERSDSQPRNLSKKSYRPPGGSGIGRSSELAVTP--STAK 218
                  GSR  +   P +    R        +  S R P  S   R S     P    A+
Sbjct: 2348 APVNIAGSRTAAALAPASLTSARMAPALSGANLTSPRVPL-SAYERVSGRTSPPLLDRAR 2406

Query: 219  CQTPTGIPSKEKSDN---PSPSSSRKVKSYGQMIIPSREKSYSPTEMSSRVKSYNQASTR 275
             +TP   PS+ +  +   PSPSS         ++ P++++  SP   +   +S      +
Sbjct: 2407 SRTPPSAPSQSRMTSERAPSPSSRMGQAPSQSLLPPAQDQPRSPVPSAFSDQS-RCLIAQ 2465

Query: 276  SRPQSHSQSRSPRRSRSGSQKRTHSRVRSHSWKRNHSRARSRTRKGILSQMGRHSQSRSH 335
            + P + SQS S     SG+   T S         +H+   S    G+         + + 
Sbjct: 2466 TTPVAGSQSLS-----SGAVATTTSSAG------DHNGMLSVPAPGVPHSDVGEPPASTG 2514

Query: 336  SKGKSQNQSRTPRRGRSHNWSRNPSKERSHSHSRSSSKERDHRGSSSPRKESGRSQSGSP 395
            ++  S   +  P + R  + S + S   S S S SSS       SSS  + S        
Sbjct: 2515 AQQPSALAALQPAKERRSSSSSSSSSSSSSSSSSSSSSSSSSGSSSSDSEGSSLPVQPEV 2574

Query: 396  NKQRDHSRSRSPNKARDRSRSRSPYKARDRSRSRSPNKARDCSRSRSPYKARDRSRSRSP 455
              +R  S + +P +A    R   P  A+ + RS S + +   S S S       S S S 
Sbjct: 2575 ALKRVPSPTPAPKEAVREGRPPEPTPAKRKRRSSSSSSSSSSSSSSS-------SSSSSS 2627

Query: 456  NKARDHSRSRSPNKARDRSRSRSPSKERDHSQLGSPSKERDHRRSRSPSKERQCRQSRSS 515
            + +   S S S + +   S S SP+K    + L  P+  +     + P  ER+ R  R  
Sbjct: 2628 SSSSSSSSSSSSSSSSSSSSSPSPAKPGPQA-LPKPASPK-----KPPPGERRSRSPRKP 2681

Query: 516  SKERDHRRSRSPSKERQRRQSRSPN-KERDRSQSRSPSEEREHRQSRSPSKERDRRRWRS 574
                   RS S S   +RR S  P+ +++  S S   S   +   SRSPS +R RR   S
Sbjct: 2682 IDSLRDSRSLSYSPVERRRPSPQPSPRDQQSSSSERGSRRGQRGDSRSPSHKR-RRETPS 2740

Query: 575  PSKERERRQSRS 586
            P   R  R SRS
Sbjct: 2741 PRPMR-HRSSRS 2751



 Score = 77.0 bits (188), Expect = 6e-14
 Identities = 171/754 (22%), Positives = 276/754 (36%), Gaps = 87/754 (11%)

Query: 3    SPKRSSKPSMSLAPSGSSMPTADPKPPASLKSTKSATPNRSLVPTKPATSRNSVMSPSSS 62
            +P  S K S S         +     PA+ + ++S TP   L+  + + SR S +S   S
Sbjct: 1844 TPPTSRKRSRSRTSPAPWKRSRSRASPATHRRSRSRTP---LISRRRSRSRTSPVSRRRS 1900

Query: 63   KSTKSTSTKRAPSNRPSSRSRVRSKARTPSRVSTDTRTSKASKASDVRCHQRRGTHSRGR 122
            +S  S + +R+ S R S  SR RS++RTP      TR    S+    R        SR R
Sbjct: 1901 RSRTSVTRRRSRS-RASPVSRRRSRSRTPPV----TRRRSRSRTPTTR------RRSRSR 1949

Query: 123  TPGRRGSRSSKRSPSRASTPGRIRTHGARPGMASRVRTPTSQQKGSRGKSYGRPRTSNRE 182
            TP     RS  R+P       R RT    P    R R+ TS     R +S   P T  R 
Sbjct: 1950 TPPVTRRRSRSRTPPVTRRRSRSRTS---PITRRRSRSRTSPVTRRRSRSRTSPVTRRRS 2006

Query: 183  RSDSQPRNLSK-KSYRPPGGSGIGRSSELAVTPSTAKCQTPTGIPSKEKSDNPSPSSSRK 241
            RS + P    + +S  PP      RS    +    ++ ++P  I  + +S  P  +  ++
Sbjct: 2007 RSRTSPVTRRRSRSRTPPAIRRRSRSRTPLLPRKRSRSRSPLAIRRRSRSRTPRTARGKR 2066

Query: 242  VKSYGQMIIPSREKSYSPTEMSSRVKSYNQASTRSRPQSHSQSRSPRRSRSGSQKRTHSR 301
              +     I  R  S S ++ S       +++T    ++HS SR+P  + + S+    SR
Sbjct: 2067 SLTRSPPAIRRRSASGSSSDRS-------RSATPPATRNHSGSRTPPVALNSSRMSCFSR 2119

Query: 302  VRSHSWKRNHSRARSRTRKGILSQMG--RHSQSRSHSKGKSQNQSRTPRRGRSHNWSRNP 359
                    +  R+      G+L  +G  R   S     G S      PR        +  
Sbjct: 2120 PSMSPTPLDRCRS-----PGMLEPLGSSRTPMSVLQQAGGSMMDGPGPRIPDH----QRT 2170

Query: 360  SKERSHSHSR--------SSSKERDHRGSSSPRKESGRSQSGSPNKQRDHSRSRSPNKAR 411
            S   +H+ SR        S    R     S+    +  SQ  +P        + + N A 
Sbjct: 2171 SVPENHAQSRIALALTAISLGTARPPPSMSAAGLAARMSQVPAPVPLMSLRTAPAANLAS 2230

Query: 412  DRSRSRSPYKARDRSRSRSPNKARDCSRSRSPYKARDRS----RSRSPNKARDHSRSRSP 467
                + +       +R+ +   A + + SR+P  A   +    R+     A + +  R+P
Sbjct: 2231 RIPAASAAAMNLASARTPAIPTAVNLADSRTPAAAAAMNLASPRTAVAPSAVNLADPRTP 2290

Query: 468  NK-ARDRSRSRSPSKERDHSQLGS---PSKERDHRRSRSPSKERQCRQSRSSSKERDHRR 523
               A + + +R+P+     S  GS   P+       SR+P            S       
Sbjct: 2291 TAPAVNLAGARTPAALAALSLTGSGTPPTAANYPSSSRTPQAPASANLVGPRSAHATAPV 2350

Query: 524  SRSPSKERQRRQSRSPNKER--------DRSQSRSPSEEREHRQSRSPSKERDRRRWRSP 575
            + + S+        S    R        + +  R P    E    R+     DR R R+P
Sbjct: 2351 NIAGSRTAAALAPASLTSARMAPALSGANLTSPRVPLSAYERVSGRTSPPLLDRARSRTP 2410

Query: 576  SKERERRQSRSSSEERDHSRSRSPNKQSGYSRPRASSKEKAHSRSRTPSKEGNHSQSRTS 635
                   QSR +SE     R+ SP+ + G + P  S    A  + R+P       QSR  
Sbjct: 2411 PSAPS--QSRMTSE-----RAPSPSSRMGQA-PSQSLLPPAQDQPRSPVPSAFSDQSRCL 2462

Query: 636  SKESDPSQSTVPRSPDWKRSPTRTSSLSQNR-----------------TPSKTSSHSPST 678
              ++ P   +   S       T TSS   +                   P+ T +  PS 
Sbjct: 2463 IAQTTPVAGSQSLSSG--AVATTTSSAGDHNGMLSVPAPGVPHSDVGEPPASTGAQQPSA 2520

Query: 679  FPSGGQTLSQDDSQADATTSKATLPGERSSSSSS 712
              +      +  S + +++S ++     SSSSSS
Sbjct: 2521 LAALQPAKERRSSSSSSSSSSSSSSSSSSSSSSS 2554



 Score = 62.4 bits (150), Expect = 1e-09
 Identities = 82/331 (24%), Positives = 129/331 (38%), Gaps = 67/331 (20%)

Query: 447 RDRSRSRSPNKARDHSRSRSPNKARDRSRSRSPSKERDHSQLGSPSKERDHRRSRSPSKE 506
           ++ +  + P     H  +    K  +R R+     +  +    S   +R  R ++ P+ E
Sbjct: 108 KEETPGQRPAVTETHQLAELNEKKNERLRAAFGISD-SYVDGSSFDPQRRAREAKQPAPE 166

Query: 507 RQ-----CRQSRSSSKERDHRRSRSPSKERQRR-QSRSPNKERDRS------QSRSPSEE 554
                   R+S SS      ++ +   K+R RR +S SP +ER +S      +S S S++
Sbjct: 167 PPKPYSLVRESSSSRSPTPKQKKKKKKKDRGRRSESSSPRRERKKSSKKKKHRSESESKK 226

Query: 555 REHR----QSRSPSKERDRRRWRS-----PSKERERRQSRSSSEERDHSRS--------- 596
           R+HR    +S+  SK++ R+R RS      S+   R  S  S+   D SRS         
Sbjct: 227 RKHRSPTPKSKRKSKDKKRKRSRSTTPAPKSRRAHRSTSADSASSSDTSRSRSRSAAAKT 286

Query: 597 -------RSPNKQSG--------YSRP------RASSKEKAHSRSRTPSKEGNHSQSRTS 635
                  RSP+  SG        +S P      R SS E A  +  +P ++ +  +   S
Sbjct: 287 HTTALAGRSPSPASGRRGEGDAPFSEPGTTSTQRPSSPETATKQPSSPYEDKDKDKKEKS 346

Query: 636 SKESDPS---QSTVPRSP----------DWKRSPTRTSSLSQN--RTPSKTSSHSPSTFP 680
           +    PS    ST P  P               P  T+ LSQ     PS+ S     + P
Sbjct: 347 ATRPSPSPERSSTGPEPPAPTPLLAERHGGSPQPLATTPLSQEPVNPPSEASPTRDRSPP 406

Query: 681 SGGQTLSQDDSQADATTSKATLPGERSSSSS 711
              + L Q  S   +  S       R +SSS
Sbjct: 407 KSPEKLPQSSSSESSPPSPQPTKVSRHASSS 437



 Score = 39.3 bits (90), Expect = 0.013
 Identities = 48/184 (26%), Positives = 83/184 (45%), Gaps = 52/184 (28%)

Query: 530 ERQRRQSRSPNKERDRSQSRSPSEEREHRQSRSPSKERDRRRWRSPSKERERRQSRSSSE 589
           +R+ R+++ P  E  +  S      RE   SRSP+ ++ +++ +   K+R RR S SSS 
Sbjct: 154 QRRAREAKQPAPEPPKPYSLV----RESSSSRSPTPKQKKKKKK---KDRGRR-SESSSP 205

Query: 590 ERDHSRSRSPNKQSGYSRPRASSKEKAHSRSRTPSKEGNHSQSRTSSKESDPSQSTVPRS 649
            R+  +S    K     R  + SK++ H RS TP      S+ ++  K+   S+ST P +
Sbjct: 206 RRERKKSSKKKKH----RSESESKKRKH-RSPTPK-----SKRKSKDKKRKRSRSTTP-A 254

Query: 650 PDWKRSPTRTSSLSQNRTPSKTSSHSPSTFPSGGQTLSQDDSQADATTSKATLPGERSSS 709
           P  +R+   TS+                            DS + + TS++     RS S
Sbjct: 255 PKSRRAHRSTSA----------------------------DSASSSDTSRS-----RSRS 281

Query: 710 SSSK 713
           +++K
Sbjct: 282 AAAK 285


>gi|21361282 splicing factor, arginine/serine-rich 4 [Homo sapiens]
          Length = 494

 Score =  175 bits (444), Expect = 1e-43
 Identities = 124/335 (37%), Positives = 179/335 (53%), Gaps = 42/335 (12%)

Query: 263 SSRVKSYNQASTRSRPQSHSQSRSPRRSRSGSQKRTHSRVRSHSWKRNHSRARSRTRKGI 322
           S R +SY+++ + SR +S S+     RSRSGS K +HS+ RS S   + SR++SR+R   
Sbjct: 179 SRRRRSYSRSRSHSRSRSRSRHSRKSRSRSGSSKSSHSKSRSRSRSGSRSRSKSRSRSQS 238

Query: 323 LSQMGRH---------SQSRSHSKGKSQNQSRTPRRGRSHN-------WSRNPSKERSHS 366
            S+  +          S+SRSHS GKS+++S+     +  N        SR+PS+ +S S
Sbjct: 239 RSRSKKEKSRSPSKEKSRSRSHSAGKSRSKSKDQAEEKIQNNDNVGKPKSRSPSRHKSKS 298

Query: 367 HSRSSSKER----DHRGSSSPRKESGRSQSGSPNKQRDHSRSRSPNKARDRSRSRSPYKA 422
            SRS S+ER    + RGS S     GRSQ  S  + R  SRS+  +++R RSRS+S  K 
Sbjct: 299 KSRSRSQERRVEEEKRGSVS----RGRSQEKSLRQSRSRSRSKGGSRSRSRSRSKSKDKR 354

Query: 423 RDRSRSRSPNKARDCSRSRSPYKARDRSRSRSPNKARDHSRSRSPNKAR---DRSRSRSP 479
           + R RSR  +++R  SRS+S        RSR     RD     S  K +   DRS+SRSP
Sbjct: 355 KGRKRSREESRSRSRSRSKS-------ERSRKRGSKRDSKAGSSKKKKKEDTDRSQSRSP 407

Query: 480 SKERDHSQLGSPSKERDHRRSRSPSKERQCRQSRSSSKERDHRRSRSPSKERQRRQSRSP 539
           S+        S SKER+H +S S  +E +     + + +    RSRS SK +    S S 
Sbjct: 408 SR--------SVSKEREHAKSESSQREGRGESENAGTNQETRSRSRSNSKSKPNLPSESR 459

Query: 540 NKERDRSQSRSPSEEREHRQSRSPSKERDRRRWRS 574
           ++ +  S++RS S+ R    SRSPS+ R R   RS
Sbjct: 460 SRSKSASKTRSRSKSRSRSASRSPSRSRSRSHSRS 494



 Score =  175 bits (443), Expect = 2e-43
 Identities = 125/355 (35%), Positives = 192/355 (54%), Gaps = 36/355 (10%)

Query: 288 RRSRSGSQKRTHSRVRSHSWKRNHSRARSRTRKGILSQMGRHSQSRSHSKGKSQNQSRTP 347
           R+ R    K    R RS+S  R+HSR+RSR+R        R S+SRS S   S ++SR+ 
Sbjct: 168 RKIRLVEDKPGSRRRRSYSRSRSHSRSRSRSRHS------RKSRSRSGSSKSSHSKSRS- 220

Query: 348 RRGRSHNWSRNPSKERSHSHSRSSSKERDHRGSSSPRKESGRSQSGSPNKQRDHSRSRSP 407
              RS + SR+ SK RS S SRS SK+   R   SP KE  RS+S S  K R  S+ ++ 
Sbjct: 221 ---RSRSGSRSRSKSRSRSQSRSRSKKEKSR---SPSKEKSRSRSHSAGKSRSKSKDQAE 274

Query: 408 NKARD-----RSRSRSPYKARDRSRSRSPNKARDCSRSRSPYKARDRSRSRSPNKARDHS 462
            K ++     + +SRSP + + +S+SRS ++ R     +    +R RS+ +S  ++R  S
Sbjct: 275 EKIQNNDNVGKPKSRSPSRHKSKSKSRSRSQERRVEEEKRGSVSRGRSQEKSLRQSRSRS 334

Query: 463 RSRSPNKARDRSRSRSPSKERDHSQLGSPSKERDHRRSRSPSKERQCRQSRSSSKERDHR 522
           RS+  +++R RSRS+S  K +   +    S+E    RSRS SK     +SR    +RD +
Sbjct: 335 RSKGGSRSRSRSRSKSKDKRKGRKR----SREESRSRSRSRSKS---ERSRKRGSKRDSK 387

Query: 523 RSRSPSKERQ---RRQSRSPNKERDRSQSRSPSEEREHRQSRSPSKERDRRRWRSPSKER 579
              S  K+++   R QSRSP        SRS S+EREH +S S  +E       + + + 
Sbjct: 388 AGSSKKKKKEDTDRSQSRSP--------SRSVSKEREHAKSESSQREGRGESENAGTNQE 439

Query: 580 ERRQSRSSSEERDHSRSRSPNKQSGYSRPRASSKEKAHSRSRTPSKEGNHSQSRT 634
            R +SRS+S+ + +  S S ++    S+ R+ SK ++ S SR+PS+  + S SR+
Sbjct: 440 TRSRSRSNSKSKPNLPSESRSRSKSASKTRSRSKSRSRSASRSPSRSRSRSHSRS 494



 Score =  165 bits (418), Expect = 1e-40
 Identities = 114/322 (35%), Positives = 164/322 (50%), Gaps = 16/322 (4%)

Query: 328 RHSQSRSHSKGKSQNQSRTPRRGRSHNWSRNPSKERSHSHSRSSSKERDH-RGSSSPRKE 386
           R S SRS S  +S+++SR  R+ RS + S   S  +S S SRS S+ R   R  S  R  
Sbjct: 182 RRSYSRSRSHSRSRSRSRHSRKSRSRSGSSKSSHSKSRSRSRSGSRSRSKSRSRSQSRSR 241

Query: 387 SGRSQSGSPNKQRDHSRSRSPNKARDRSRSRSPYKARDRSRSRSPNKARDCSRSRSPYKA 446
           S + +S SP+K++  SRS S  K+R +S+ ++  K ++      P K+R  SR +S  K+
Sbjct: 242 SKKEKSRSPSKEKSRSRSHSAGKSRSKSKDQAEEKIQNNDNVGKP-KSRSPSRHKSKSKS 300

Query: 447 RDRSRSR--SPNKARDHSRSRSPNKARDRSRSRSPSKERDHSQLGSPSKERDHRRSRSPS 504
           R RS+ R     K    SR RS  K+  +SRSRS SK    S+  S SK +D R+ R  S
Sbjct: 301 RSRSQERRVEEEKRGSVSRGRSQEKSLRQSRSRSRSKGGSRSRSRSRSKSKDKRKGRKRS 360

Query: 505 KERQCRQSRSSSKERDHRRSRSPSKERQRRQSRSPNKERDRSQSRSPSEEREHRQSRSPS 564
           +E    +SRS SK    R+  S    +     +   ++ DRSQSRSPS        RS S
Sbjct: 361 REESRSRSRSRSKSERSRKRGSKRDSKAGSSKKKKKEDTDRSQSRSPS--------RSVS 412

Query: 565 KERDRRRWRSPSKERERRQSRSSSEERDHSRSRSPNKQS----GYSRPRASSKEKAHSRS 620
           KER+  +  S  +E       + + +   SRSRS +K        SR R+ S  K  SRS
Sbjct: 413 KEREHAKSESSQREGRGESENAGTNQETRSRSRSNSKSKPNLPSESRSRSKSASKTRSRS 472

Query: 621 RTPSKEGNHSQSRTSSKESDPS 642
           ++ S+  + S SR+ S+    S
Sbjct: 473 KSRSRSASRSPSRSRSRSHSRS 494



 Score =  149 bits (377), Expect = 7e-36
 Identities = 114/340 (33%), Positives = 175/340 (51%), Gaps = 37/340 (10%)

Query: 383 PRKESGRSQSGSPNKQRDHSRSRSPNKARDRSRSRSPYKARDRSRSRSPNKARDCSRSRS 442
           P     RS S S +  R  SRSR   K+R RS S     ++ RSRSRS +++R  SRSRS
Sbjct: 177 PGSRRRRSYSRSRSHSRSRSRSRHSRKSRSRSGSSKSSHSKSRSRSRSGSRSRSKSRSRS 236

Query: 443 PYKARDRS-RSRSPNKARDHSRSRSPNKARDRSRSRSPSKERDHSQLGSPSKERDHRRSR 501
             ++R +  +SRSP+K +  SRS S  K+R +S+ ++  K +++  +G P       +SR
Sbjct: 237 QSRSRSKKEKSRSPSKEKSRSRSHSAGKSRSKSKDQAEEKIQNNDNVGKP-------KSR 289

Query: 502 SPSKERQCRQSRSSSKERDHRRSRSPSKERQRRQSRSPNKERDRSQSRSPSEEREHRQSR 561
           SPS                  R +S SK R R Q R   +E+  S SR  S+E+  RQSR
Sbjct: 290 SPS------------------RHKSKSKSRSRSQERRVEEEKRGSVSRGRSQEKSLRQSR 331

Query: 562 SPSKER--DRRRWRSPSKERERRQSRSSSEERDHSRSRSPNKQSGYSRPRASSKEKAHSR 619
           S S+ +   R R RS SK +++R+ R  S E   SRSRS +K S  SR R S ++     
Sbjct: 332 SRSRSKGGSRSRSRSRSKSKDKRKGRKRSREESRSRSRSRSK-SERSRKRGSKRDSKAGS 390

Query: 620 SRTPSKEG-----NHSQSRTSSKESDPSQSTVPRSP---DWKRSPTRTSSLSQNRTPSKT 671
           S+   KE      + S SR+ SKE + ++S   +     + + + T   + S++R+ SK+
Sbjct: 391 SKKKKKEDTDRSQSRSPSRSVSKEREHAKSESSQREGRGESENAGTNQETRSRSRSNSKS 450

Query: 672 SSHSPSTFPSGGQTLSQDDSQADATTSKATLPGERSSSSS 711
             + PS   S  ++ S+  S++ + +  A+    RS S S
Sbjct: 451 KPNLPSESRSRSKSASKTRSRSKSRSRSASRSPSRSRSRS 490



 Score =  139 bits (350), Expect = 9e-33
 Identities = 113/368 (30%), Positives = 187/368 (50%), Gaps = 52/368 (14%)

Query: 75  SNRPSSRSRVRSKARTPSRVSTDTRTSKASKASDVRCHQRRGTHSRGRTPGRRGSRSSKR 134
           S R  S SR RS +R+ SR       S+ S+ S  R    + +HS+ R+  R GSRS  +
Sbjct: 179 SRRRRSYSRSRSHSRSRSR-------SRHSRKSRSRSGSSKSSHSKSRSRSRSGSRSRSK 231

Query: 135 SPSRASTPGRIRTHGARPGMASRVRTPTSQQKGSRGKSYGRPRTSNRERSDSQPRNLSKK 194
           S SR+ +  R +          + R+P+ ++  SR  S G+ R+ ++++++ + +N    
Sbjct: 232 SRSRSQSRSRSKKE--------KSRSPSKEKSRSRSHSAGKSRSKSKDQAEEKIQN---- 279

Query: 195 SYRPPGGSGIGRSSELAVTPSTAKCQTPTGIPSKEKSDNPSPSSSRKVKSYGQMIIPSRE 254
                    +G+           K ++P+   SK KS   S S  R+V+          E
Sbjct: 280 ------NDNVGKP----------KSRSPSRHKSKSKSR--SRSQERRVEE---------E 312

Query: 255 KSYSPTEMSSRVKSYNQASTRSRPQSHSQSRSPRRSRSGSQKRTHSRVRSHSWKRNHSRA 314
           K  S +   S+ KS  Q+ +RSR +  S+SRS  RSRS S+ +   R RS    R+ SR+
Sbjct: 313 KRGSVSRGRSQEKSLRQSRSRSRSKGGSRSRS--RSRSKSKDKRKGRKRSREESRSRSRS 370

Query: 315 RSRTRKGILSQMGRHSQSRSHSKGKSQNQSRTPRRGRSHNWSRNPSKERSHSHSRSSSKE 374
           RS++ +       R S++ S  K K ++  R+    +S + SR+ SKER H+ S SS +E
Sbjct: 371 RSKSERSRKRGSKRDSKAGSSKKKKKEDTDRS----QSRSPSRSVSKEREHAKSESSQRE 426

Query: 375 RDHRGSSSPRKESGRSQSGSPNKQRDHSRSRSPNKARDRSRSRSPYKARDRSRSRSPNKA 434
                 ++   +  RS+S S +K + +  S S ++++  S++RS  K+R RS SRSP+++
Sbjct: 427 GRGESENAGTNQETRSRSRSNSKSKPNLPSESRSRSKSASKTRSRSKSRSRSASRSPSRS 486

Query: 435 RDCSRSRS 442
           R  S SRS
Sbjct: 487 RSRSHSRS 494



 Score =  138 bits (347), Expect = 2e-32
 Identities = 111/325 (34%), Positives = 175/325 (53%), Gaps = 44/325 (13%)

Query: 175 RPRTSNRERSDSQPRNLSKKSYRPPGGSGIGRSSELAVTPSTAKCQTPTGIPSKEKSDNP 234
           R R+ +R RS S+ R+ S+ S +    SG  +SS      S ++ ++ +G  S+ KS + 
Sbjct: 181 RRRSYSRSRSHSRSRSRSRHSRKSRSRSGSSKSSH-----SKSRSRSRSGSRSRSKSRSR 235

Query: 235 SPSSSRKVKSYGQMIIPSREKSYSPTEMS--SRVKSYNQASTRSRPQSH---SQSRSPRR 289
           S S SR  K   +   PS+EKS S +  +  SR KS +QA  + +   +    +SRSP R
Sbjct: 236 SQSRSRSKKEKSRS--PSKEKSRSRSHSAGKSRSKSKDQAEEKIQNNDNVGKPKSRSPSR 293

Query: 290 SRSGSQKRTHSRVRSHSWKRNHSRARSRTRKGILSQMGRHSQSRSHSKGKSQNQSRTPRR 349
            +S S+ R+ S+ R    ++  S +R R+++  L    R S+SRS SKG S+++SR+  +
Sbjct: 294 HKSKSKSRSRSQERRVEEEKRGSVSRGRSQEKSL----RQSRSRSRSKGGSRSRSRSRSK 349

Query: 350 GRSHNWSRNPSKERSHSHSRSSSK---------ERDHRGSSSPRK---ESGRSQSGSPN- 396
            +     R  S+E S S SRS SK         +RD +  SS +K   ++ RSQS SP+ 
Sbjct: 350 SKDKRKGRKRSREESRSRSRSRSKSERSRKRGSKRDSKAGSSKKKKKEDTDRSQSRSPSR 409

Query: 397 ---KQRDHSRSRSPNKA------------RDRSRSRSPYKARDRSRSRSPNKARDCSRSR 441
              K+R+H++S S  +               RSRSRS  K++    S S ++++  S++R
Sbjct: 410 SVSKEREHAKSESSQREGRGESENAGTNQETRSRSRSNSKSKPNLPSESRSRSKSASKTR 469

Query: 442 SPYKARDRSRSRSPNKARDHSRSRS 466
           S  K+R RS SRSP+++R  S SRS
Sbjct: 470 SRSKSRSRSASRSPSRSRSRSHSRS 494



 Score =  127 bits (318), Expect = 5e-29
 Identities = 92/290 (31%), Positives = 149/290 (51%), Gaps = 19/290 (6%)

Query: 438 SRSRSPYKARDRSRSRSPNKARDHSRSRS------PNKARDRSRSRSPSKERDHSQLGSP 491
           SR R  Y +R RS SRS +++R   +SRS       + ++ RSRSRS S+ R  S+  S 
Sbjct: 179 SRRRRSY-SRSRSHSRSRSRSRHSRKSRSRSGSSKSSHSKSRSRSRSGSRSRSKSRSRSQ 237

Query: 492 SKERDHR-RSRSPSKERQCRQSRSSSKERDHRRSRSPSKERQ-----RRQSRSPNKERDR 545
           S+ R  + +SRSPSKE+   +S S+ K R   + ++  K +      + +SRSP++ + +
Sbjct: 238 SRSRSKKEKSRSPSKEKSRSRSHSAGKSRSKSKDQAEEKIQNNDNVGKPKSRSPSRHKSK 297

Query: 546 SQSRSPSEEREHRQSRSPSKERDRRRWRSPSKERERRQSRSSSEERDHSRSRSPNKQSGY 605
           S+SRS S+ER   + +  S  R R + +S  + R R +S+  S  R  SRS+S +K+ G 
Sbjct: 298 SKSRSRSQERRVEEEKRGSVSRGRSQEKSLRQSRSRSRSKGGSRSRSRSRSKSKDKRKGR 357

Query: 606 SRPRASSKEKAHSRSRT--PSKEGNHSQSRTSSKESDPSQSTVPRSPDWKRSPTRTSSLS 663
            R R  S+ ++ SRS++    K G+   S+  S +    + T        RSP+R+ S  
Sbjct: 358 KRSREESRSRSRSRSKSERSRKRGSKRDSKAGSSKKKKKEDT---DRSQSRSPSRSVSKE 414

Query: 664 QNRTPSKTSSHSPSTFPSGGQTLSQDDSQADATT-SKATLPGERSSSSSS 712
           +    S++S            T  +  S++ + + SK  LP E  S S S
Sbjct: 415 REHAKSESSQREGRGESENAGTNQETRSRSRSNSKSKPNLPSESRSRSKS 464



 Score = 94.0 bits (232), Expect = 4e-19
 Identities = 100/389 (25%), Positives = 177/389 (45%), Gaps = 65/389 (16%)

Query: 2   SSPKRSSKPSMSLAPSGSSMPTADPKPPASLKSTKSATPNRSLVPTKPATSRNSVMSPSS 61
           S  KR+ +       +G  +   + KP +  + + S + + S   ++   SR S     S
Sbjct: 151 SDMKRALEKLDGTEVNGRKIRLVEDKPGSRRRRSYSRSRSHSRSRSRSRHSRKSRSRSGS 210

Query: 62  SKSTKSTSTKRAPS---NRPSSRSRVRS-------KARTPSRVSTDTRTSKA----SKAS 107
           SKS+ S S  R+ S   +R  SRSR +S       K+R+PS+  + +R+  A    SK+ 
Sbjct: 211 SKSSHSKSRSRSRSGSRSRSKSRSRSQSRSRSKKEKSRSPSKEKSRSRSHSAGKSRSKSK 270

Query: 108 DVRCHQRRGTHSRG----RTPGRRGSRSSKRSPSRASTPGRIRTHGARPGMASRVRT--P 161
           D    + +   + G    R+P R  S+S  RS S+       R    + G  SR R+   
Sbjct: 271 DQAEEKIQNNDNVGKPKSRSPSRHKSKSKSRSRSQER-----RVEEEKRGSVSRGRSQEK 325

Query: 162 TSQQKGSRGKSYGRPRTSNRERSDSQPRNLSKKSYRPPGGSGIGRSSELAVTPSTAKCQT 221
           + +Q  SR +S G  R+ +R RS S+ +   +K           RS E + + S ++ ++
Sbjct: 326 SLRQSRSRSRSKGGSRSRSRSRSKSKDKRKGRK-----------RSREESRSRSRSRSKS 374

Query: 222 PTGIPSKEKSDNPSPSSSRKVKSYGQMIIPSREKSYSPTEMSSRVKSYNQASTRSRPQSH 281
                   K D+ + SS +K K                 E + R +S + + + S+ + H
Sbjct: 375 ERSRKRGSKRDSKAGSSKKKKK-----------------EDTDRSQSRSPSRSVSKEREH 417

Query: 282 SQSRSPRRSRSGSQKRTHSRVRSHSWKRNHSRARSRTRKGILSQMGRHSQSRSHSKGKSQ 341
           ++S S +R   G  +   +   + S     SR+ S+++  + S+    S+S S ++ +S+
Sbjct: 418 AKSESSQREGRGESENAGTNQETRS----RSRSNSKSKPNLPSESRSRSKSASKTRSRSK 473

Query: 342 NQSRTPRRGRSHNWSRNPSKERSHSHSRS 370
           ++SR+         SR+PS+ RS SHSRS
Sbjct: 474 SRSRSA--------SRSPSRSRSRSHSRS 494



 Score = 92.0 bits (227), Expect = 2e-18
 Identities = 77/246 (31%), Positives = 122/246 (49%), Gaps = 31/246 (12%)

Query: 494 ERDHRRSRSPSKERQCRQSRSSSKERDHRRSRSPSKERQRRQSRSPNKE----RDRSQSR 549
           E + R+ R    +   R+ RS S+ R H RSRS S+  ++ +SRS + +    + RS+SR
Sbjct: 164 EVNGRKIRLVEDKPGSRRRRSYSRSRSHSRSRSRSRHSRKSRSRSGSSKSSHSKSRSRSR 223

Query: 550 SPSEEREHRQSRSPSKERDRR-RWRSPSKERERRQSRSSSEERDHS-------------- 594
           S S  R   +SRS S+ R ++ + RSPSKE+ R +S S+ + R  S              
Sbjct: 224 SGSRSRSKSRSRSQSRSRSKKEKSRSPSKEKSRSRSHSAGKSRSKSKDQAEEKIQNNDNV 283

Query: 595 ---RSRSPNKQSGYSRPRASS------KEKAHSRSRTPSKEGNHSQSRTSSKESDPSQST 645
              +SRSP++    S+ R+ S      +EK  S SR  S+E +  QSR+ S+    S+S 
Sbjct: 284 GKPKSRSPSRHKSKSKSRSRSQERRVEEEKRGSVSRGRSQEKSLRQSRSRSRSKGGSRS- 342

Query: 646 VPRSPDWKRSPTRTSSLSQNRTPSKTSSHSPSTFPSGGQTLSQDDSQADATTSKATLPGE 705
             RS    +S  +     ++R  S++ S S S      +  S+ DS+A ++  K     +
Sbjct: 343 --RSRSRSKSKDKRKGRKRSREESRSRSRSRSKSERSRKRGSKRDSKAGSSKKKKKEDTD 400

Query: 706 RSSSSS 711
           RS S S
Sbjct: 401 RSQSRS 406



 Score = 54.7 bits (130), Expect = 3e-07
 Identities = 44/128 (34%), Positives = 65/128 (50%), Gaps = 14/128 (10%)

Query: 587 SSEERDHSRSRSPNKQSGYSRPRASSKEKAHSRSRTPSKEGNHSQSRTSSKESDPSQSTV 646
           S   R +SRSRS      +SR R+ S+    SRSR+ S + +HS+SR+ S+    S    
Sbjct: 179 SRRRRSYSRSRS------HSRSRSRSRHSRKSRSRSGSSKSSHSKSRSRSRSGSRS---- 228

Query: 647 PRSPDWKRSPTRT-SSLSQNRTPSKTSSHSPSTFPSGGQTLSQDDSQADATTSKATLPGE 705
            RS    RS +R+ S   ++R+PSK  S S S   S G++ S+   QA+         G+
Sbjct: 229 -RSKSRSRSQSRSRSKKEKSRSPSKEKSRSRS--HSAGKSRSKSKDQAEEKIQNNDNVGK 285

Query: 706 RSSSSSSK 713
             S S S+
Sbjct: 286 PKSRSPSR 293


>gi|42560244 peptidylprolyl isomerase G [Homo sapiens]
          Length = 754

 Score =  163 bits (412), Expect = 6e-40
 Identities = 159/597 (26%), Positives = 258/597 (43%), Gaps = 60/597 (10%)

Query: 99  RTSKASKA-SDVRCHQRRGTHSRGRTPGRRGSRSSKRSPSRASTPGRIRTHGARPGMASR 157
           +T  ASK  ++VR         + +       R    S S +S+     +  ++    S 
Sbjct: 158 KTDAASKPFAEVRILSCGELIPKSKVKKEEKKRHKSSSSSSSSSSDSDSSSDSQSSSDSS 217

Query: 158 VRTPTSQQKGSRGKSYGRPRTSNRERSDSQPRNLSKKSYRPPGGSGIGRSSELAVTP-ST 216
                +++K  + K   R + S + + + + R  SKKS      S    +  L   P ST
Sbjct: 218 DSESATEEKSKKRKKKHR-KNSRKHKKEKKKRKKSKKS-----ASSESEAENLEAQPQST 271

Query: 217 AKCQTPTGIPSKEKSDNPSPSSSRKVKSYGQMIIPSREKSYSPTEMSSRVKSYNQASTRS 276
            + +    IP        SP  + + +   +     RE+       +S+  SY +    +
Sbjct: 272 VRPEEIPPIPENRFLMRKSPPKADEKERKNR----ERERERECNPPNSQPASYQRRLLVT 327

Query: 277 RPQSHSQSRSPRRSRSGSQKRTHSRVRSHS----WKRNHSRAR-------SRTRKGILSQ 325
           R     + R PRR R+ S+ R+  R R       W++   RA+        R  KG  S+
Sbjct: 328 RSGRKIKGRGPRRYRTPSRSRSRDRFRRSETPPHWRQEMQRAQRMRVSSGERWIKGDKSE 387

Query: 326 MGRHSQSRSHSKGKSQNQSRTPRRGRSHNWSRNPSKERSHSHSRSSSKERDHRGSSSPRK 385
           +    +++  S  + + +  T  R  S + +R   KE+     +S+SKERD R +S    
Sbjct: 388 LNEIKENQ-RSPVRVKERKITDHRNVSESPNRKNEKEKKVKDHKSNSKERDIRRNSE--- 443

Query: 386 ESGRSQSGSPNKQRDHSRSRSPNKARDRSRSRSPYKARDRSRSRSPNKARDCSRSRSPYK 445
                     +K ++  + R+ +K+R +S+ +S  K RD   +R+  K     R RS  K
Sbjct: 444 --------KDDKYKNKVKKRAKSKSRSKSKEKSKSKERDSKHNRNEEK-----RMRSRSK 490

Query: 446 ARDRSRSRSPNKARDHSRSRSPNKARDRSRSRSPSKERDHSQLGSPSKERDHRRS----- 500
            RD    +   K  D       +K +D+ RSRS  K +   QL S S E DH +S     
Sbjct: 491 GRDHENVKEKEKQSD-------SKGKDQERSRSKEKSK---QLESKSNEHDHSKSKEKDR 540

Query: 501 RSPSKERQCRQSRSSSKERDHRRSRSPSKERQRRQSRSPNKERDRSQSRSPSEEREH--- 557
           R+ S+ R+C  ++         R RS S++R RR  RS   +RDRS+S+     RE    
Sbjct: 541 RAQSRSRECDITKGKHSYNSRTRERSRSRDRSRRV-RSRTHDRDRSRSKEYHRYREQEYR 599

Query: 558 RQSRSPSKERDRRRWRSPSKERERRQSRSSSEERDHSRSRSPNKQSGYSRPRASSKEKAH 617
           R+ RS S+ER     RS SK+R RR+  S S ER+ S+SR+ +K        +  KE + 
Sbjct: 600 RRGRSRSRERRTPPGRSRSKDRRRRRRDSRSSEREESQSRNKDKYRNQESKSSHRKENSE 659

Query: 618 SRSRTPSKEGNHSQSRTS-SKESDPSQSTVPRSPDWKRSPTRTSSLSQNRTPSKTSS 673
           S  R  SK  +H+ S  S  K++D  QS   +     +     SS+ +N+   K  S
Sbjct: 660 SEKRMYSKSRDHNSSNNSREKKADRDQSPFSKIKQSSQDNELKSSMLKNKEDEKIRS 716



 Score =  155 bits (393), Expect = 9e-38
 Identities = 150/593 (25%), Positives = 253/593 (42%), Gaps = 47/593 (7%)

Query: 66  KSTSTKRAPSNRPSSRSRVRSKARTPSRVSTDTRTSKASKASDVRCHQRRGTHSRGRTPG 125
           K    KR  S+  SS S   S + + S+ S+D+  S++  A++ +  +R+  H +     
Sbjct: 184 KKEEKKRHKSSSSSSSSSSDSDSSSDSQSSSDSSDSES--ATEEKSKKRKKKHRKNSRKH 241

Query: 126 RRGSRSSKRSPSRASTPGRIRTHGARPGMASRVRT--PTSQQKGSRGKSYGRPRTSNRER 183
           ++  +  K+S   AS+        A+P    R     P  + +    KS   P+   +ER
Sbjct: 242 KKEKKKRKKSKKSASSESEAENLEAQPQSTVRPEEIPPIPENRFLMRKS--PPKADEKER 299

Query: 184 SDSQPRNLSKKSYRPPGGSGIGRSSELAVTPSTAKCQTPTGIPSKEKSDNPSPSSSRKVK 243
            + +     ++   PP          L VT S  K      I  +      +PS SR   
Sbjct: 300 KNRERER--ERECNPPNSQPASYQRRLLVTRSGRK------IKGRGPRRYRTPSRSRSRD 351

Query: 244 SYGQMIIPSREKSYSPTEMSSRVKS---YNQASTRSRPQSHSQSRSPRRSRSGSQKRT-H 299
            + +   P   +         RV S   + +       +     RSP R +   +K T H
Sbjct: 352 RFRRSETPPHWRQEMQRAQRMRVSSGERWIKGDKSELNEIKENQRSPVRVKE--RKITDH 409

Query: 300 SRVRSHSWKRNHSRARSRTRKGILSQMGRHSQSRSHSKGKSQNQSRTPRRGRSHNWSRNP 359
             V     ++N    + +  K    +      S    K K++ + R   + RS +  ++ 
Sbjct: 410 RNVSESPNRKNEKEKKVKDHKSNSKERDIRRNSEKDDKYKNKVKKRAKSKSRSKSKEKSK 469

Query: 360 SKERSHSHSRSSSKERDHRGSSSPRKESGRSQSGSPNKQRDHSRSRSPNKARD---RSRS 416
           SKER   H+R+  K    R      +     +  S +K +D  RSRS  K++    +S  
Sbjct: 470 SKERDSKHNRNEEKRMRSRSKGRDHENVKEKEKQSDSKGKDQERSRSKEKSKQLESKSNE 529

Query: 417 RSPYKARDRSRSRSPNKARDC--SRSRSPYKARDRSRSRSPNKARDHSRSRSPNKARDRS 474
               K++++ R R+ +++R+C  ++ +  Y +R R RSRS +++R   R RS    RDRS
Sbjct: 530 HDHSKSKEKDR-RAQSRSRECDITKGKHSYNSRTRERSRSRDRSR---RVRSRTHDRDRS 585

Query: 475 RSRSPSKERDHSQLGSPSKERDHRRSRSPSKERQCRQSRSSSKERDHRRSRSPSKERQRR 534
           RS+   + R+         +   RR RS S+ER+    RS SK+R  RR  S S ER+  
Sbjct: 586 RSKEYHRYRE---------QEYRRRGRSRSRERRTPPGRSRSKDRRRRRRDSRSSEREES 636

Query: 535 QSRSPNKERDRSQSRSPSEEREHRQSRSPSKERDRRRW-RSPSKERERRQS-----RSSS 588
           QSR+ +K R++    S  +E    + R  SK RD      S  K+ +R QS     + SS
Sbjct: 637 QSRNKDKYRNQESKSSHRKENSESEKRMYSKSRDHNSSNNSREKKADRDQSPFSKIKQSS 696

Query: 589 EERDHSRSRSPNKQSGYSRPRASSKEKAHSRSRTPSKEGNHSQSRTSSKESDP 641
           ++ +   S   NK+    R   SS EK + +S+    +  H +++    ES P
Sbjct: 697 QDNELKSSMLKNKEDEKIR---SSVEKENQKSKGQENDHVHEKNKKFDHESSP 746



 Score = 93.6 bits (231), Expect = 6e-19
 Identities = 120/493 (24%), Positives = 198/493 (40%), Gaps = 65/493 (13%)

Query: 21  MPTADPKPPASLKSTKSATPNRSLVP--TKPATSRNSVMSPSSSKSTKSTSTKRAPS-NR 77
           M  + PK     +  +     R   P  ++PA+ +  ++   S +  K    +R  + +R
Sbjct: 287 MRKSPPKADEKERKNRERERERECNPPNSQPASYQRRLLVTRSGRKIKGRGPRRYRTPSR 346

Query: 78  PSSRSRVRSKARTPS-----------RVSTDTRTSKASKA----------SDVRCHQRRG 116
             SR R R     P            RVS+  R  K  K+          S VR  +R+ 
Sbjct: 347 SRSRDRFRRSETPPHWRQEMQRAQRMRVSSGERWIKGDKSELNEIKENQRSPVRVKERKI 406

Query: 117 THSRG--RTPGRRGSRSSKRSPSRASTPGR-IRTHGARPGMASRVRTPTSQQKGSRGKSY 173
           T  R    +P R+  +  K    ++++  R IR +  +     + +    ++  S+ +S 
Sbjct: 407 TDHRNVSESPNRKNEKEKKVKDHKSNSKERDIRRNSEKD---DKYKNKVKKRAKSKSRSK 463

Query: 174 GRPRTSNRERSDSQPRNLSKKSYRPPGGSGIGRSSELAVTPSTAKCQTPTGIPSKEKSDN 233
            + ++ ++ER     RN  K+      G       E     S +K +      SKEKS  
Sbjct: 464 SKEKSKSKERDSKHNRNEEKRMRSRSKGRDHENVKEKE-KQSDSKGKDQERSRSKEKSKQ 522

Query: 234 PSPSSSRKVKSYGQMIIPSREKSYSPTEMSSRVKSYNQASTRSRPQSHSQSRSPRRSRSG 293
               S+    S  +      +      +++    SYN   +R+R +S S+ RS RR RS 
Sbjct: 523 LESKSNEHDHSKSKEKDRRAQSRSRECDITKGKHSYN---SRTRERSRSRDRS-RRVRS- 577

Query: 294 SQKRTHSRVRSHSWKRNHSRARSRTRKGILSQMGRHSQSRSHSKGKSQNQSRTPRRGRSH 353
              RTH R RS S + +  R +   R+G         +SRS  +     +SR+  R R  
Sbjct: 578 ---RTHDRDRSRSKEYHRYREQEYRRRG---------RSRSRERRTPPGRSRSKDRRRRR 625

Query: 354 NWSRNPSKERSHSHSRSSSKERDHRGSSSPRKESGRSQSGSPNKQRDHSRSRSPNKARDR 413
             SR  S ER  S SR+  K R+    SS RKE+  S+    +K RDH+ S + ++ +  
Sbjct: 626 RDSR--SSEREESQSRNKDKYRNQESKSSHRKENSESEKRMYSKSRDHNSSNN-SREKKA 682

Query: 414 SRSRSPYK-----ARDRSRSRSPNKARDCSRSRSPY-------KARDRSRSRSPNKARDH 461
            R +SP+      ++D     S  K ++  + RS         K ++       NK  DH
Sbjct: 683 DRDQSPFSKIKQSSQDNELKSSMLKNKEDEKIRSSVEKENQKSKGQENDHVHEKNKKFDH 742

Query: 462 SRSRSPNKARDRS 474
             S  P    D+S
Sbjct: 743 ESS--PGTDEDKS 753



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 57/249 (22%), Positives = 92/249 (36%), Gaps = 23/249 (9%)

Query: 58  SPSSSKSTKSTSTKRAPSNRPSSRSRVRSKAR----TPSRVSTDTRTSKASKASDVRCHQ 113
           S   SK  +S S +   S       R +S++R    T  + S ++RT + S++ D     
Sbjct: 516 SKEKSKQLESKSNEHDHSKSKEKDRRAQSRSRECDITKGKHSYNSRTRERSRSRDRSRRV 575

Query: 114 RRGTHSRGRTPGRR---------GSRSSKRSPSRASTPGRIRTHGARPGMASRVRTPTSQ 164
           R  TH R R+  +            R   RS  R + PGR R+   R     R R  +  
Sbjct: 576 RSRTHDRDRSRSKEYHRYREQEYRRRGRSRSRERRTPPGRSRSKDRR-----RRRRDSRS 630

Query: 165 QKGSRGKSYGRPRTSNRERSDSQPRNLSKKSYRPPGGSGIGRSSELAVTPSTAKCQTPTG 224
            +    +S  + +  N+E   S  +  S+   R    S    SS  +      + Q+P  
Sbjct: 631 SEREESQSRNKDKYRNQESKSSHRKENSESEKRMYSKSRDHNSSNNSREKKADRDQSPFS 690

Query: 225 IPSKEKSDNPSPSSSRKVKSYGQMIIPSREKSYSPTEMSSRVKSYNQASTRSRPQSHSQS 284
              +   DN   SS  K K   + I  S EK        S+ +  +    +++   H  S
Sbjct: 691 KIKQSSQDNELKSSMLKNKE-DEKIRSSVEKE----NQKSKGQENDHVHEKNKKFDHESS 745

Query: 285 RSPRRSRSG 293
                 +SG
Sbjct: 746 PGTDEDKSG 754


>gi|153251865 hypothetical protein LOC84226 [Homo sapiens]
          Length = 1984

 Score =  158 bits (400), Expect = 1e-38
 Identities = 198/783 (25%), Positives = 290/783 (37%), Gaps = 122/783 (15%)

Query: 8    SKPSMSLAPSGSSMPTADPKPPASLKSTKSATPNR---SLVPTKPATSRNSVMSPSSSK- 63
            S PS S AP    +       P  ++ TK+  P     + V   P +   S  +   +K 
Sbjct: 1219 SGPSQSPAPVQVYIRRGQRSRPDLVEKTKTRAPGHYEFTQVHNLPESDSESTQNEKRAKV 1278

Query: 64   STKSTSTKRAPSNRPSSRSRVRSKARTPSRVSTDTRTSKASKASDVRCHQRRGTHSRGRT 123
             TK TS  + P  R + R R   K        T++RT+  S + ++  H RR      +T
Sbjct: 1279 RTKKTSDSKYPMKRITKRLRKHRK------FYTNSRTTIESPSRELAAHLRRKRIGATQT 1332

Query: 124  PGRRGSRSSKRSPSRASTP------------------------GRIRTHGARPGM----- 154
                 + S KR P + S P                        GR    G RP       
Sbjct: 1333 ----STASLKRQPKKPSQPKFMQLLFQSLKRAFQTAHRVIASVGRKPVDGTRPDNLWASK 1388

Query: 155  -------ASRVRTPTSQQKGSRGKSYGRPRTSNRERSD------------SQPRNLSKKS 195
                   A     P+S ++  R      P  S  ++ D             QPR      
Sbjct: 1389 NYYPKQNARDYCLPSSIKRDKRSADKLTPAGSTIKQEDILWGGTVQCRSAQQPRRAYSFQ 1448

Query: 196  YRP---PGGSGIGRSSELAVTPSTAKCQTPTGIPSKEKSDNPSPSSSRKVKSYGQMIIPS 252
             RP   P  +     S+  +   TA    P     K+       SSSR  K++ +    S
Sbjct: 1449 PRPLRLPKPT----DSQSGIAFQTASVGQPLRTVQKD-------SSSRSKKNFYRNETSS 1497

Query: 253  REKSYSPTEMSSRVKSYNQASTRSRPQ-----------SHSQSRSPRRSRSGSQKRTHSR 301
            +E     T   +RV++  +    S  +           +H +   P   R  + +    R
Sbjct: 1498 QESKNLSTP-GTRVQARGRILPGSPVKRTWHRHLKDKLTHKEHNHPSFYRERTPRGPSER 1556

Query: 302  VRSHSWKRNHSRARSRTRKGILSQMGRHSQSRSHSKGKSQNQSRTPRRGRSHNWSRNPSK 361
             R +   RNH     R+++  L +       RSH     +N S    R    +W R+PS+
Sbjct: 1557 TRHNPSWRNHRSPSERSQRSSLERRHHSPSQRSHCSPSRKNHSSPSER----SW-RSPSQ 1611

Query: 362  ERSHSHSRSSSKERDHRGSSSPRKESGRSQSGSPNKQRDHSRS----RSPNKARDRSRSR 417
                S    S      RG  SP + S R     P+++R HS S    RSP++   RS S 
Sbjct: 1612 RNHCSPPERSCHSLSERGLHSPSQRSHRG----PSQRRHHSPSERSHRSPSERSHRSSSE 1667

Query: 418  SPYKARDRSRSRSPNKARDCSRSRSPYKARDRSRSRSPNKARDHSRSRSPNKARDRSRSR 477
              +++  +   R P++   CS S   +++  +   R P++ R HS S+  +++  R   R
Sbjct: 1668 RRHRSPSQRSHRGPSERSHCSPSERRHRSPSQRSHRGPSERRHHSPSKRSHRSPARRSHR 1727

Query: 478  SPSKERDHSQLGSPSKERDHRRSRSPSKERQCRQSRSSSKERDHRRSRSPSKERQRRQSR 537
            SPS+   HS           RR  SPS+   C  S  S      RR RSPS+ R    S 
Sbjct: 1728 SPSERSHHSPSERSHHSPSERRHHSPSERSHCSPSERSHCSPSERRHRSPSERRHHSPSE 1787

Query: 538  SPNKERDRSQSRSPSEEREHRQSRSPSKERDRRRWRSPSKERERRQSRSSSEERDHSRSR 597
              +         SPSE R H            R  RSPS+ R  R S   S  R   RS 
Sbjct: 1788 KSHHSPSERSHHSPSERRRHSPLERSRHSLLERSHRSPSERRSHR-SFERSHRRISERSH 1846

Query: 598  SPNKQSGYSRPRASSKEKAHSRSRTPSKEGNHSQSRTSSKESDPSQSTVPRSPDWKRSPT 657
            SP+++S  S           SR     + G+ S  +T    S+ S     RSP   R   
Sbjct: 1847 SPSEKSHLS-------PLERSRCSPSERRGHSSSGKTCHSPSERSH----RSPSGMRQ-G 1894

Query: 658  RTSSLSQNRTPSKTSSHSPSTF----PSGGQTLSQDDSQADATTS---KATLPGERSSSS 710
            RTS  S +R+  + + HSPS      PSG    S  +    +      K + PGER S S
Sbjct: 1895 RTSERS-HRSSCERTRHSPSEMRPGRPSGRNHCSPSERSRRSPLKEGLKYSFPGERPSHS 1953

Query: 711  SSK 713
             S+
Sbjct: 1954 LSR 1956



 Score =  119 bits (297), Expect = 1e-26
 Identities = 175/612 (28%), Positives = 246/612 (40%), Gaps = 62/612 (10%)

Query: 2    SSPKRSSKPSMSLAPSGSSMPTADPKPPASLKSTKSATPNRSLVPTKPATSRNSVMSPSS 61
            SS KR  + +  L P+GS++   D     +++   +  P R+    +P   R    + S 
Sbjct: 1403 SSIKRDKRSADKLTPAGSTIKQEDILWGGTVQCRSAQQPRRAY-SFQPRPLRLPKPTDSQ 1461

Query: 62   SKSTKSTSTKRAPSNRPSSRSRVRSKARTPSRVSTDTRTSKASKASDVRCHQRRGTHSRG 121
            S     T++   P       S  RSK +   R  T ++ SK       R        +RG
Sbjct: 1462 SGIAFQTASVGQPLRTVQKDSSSRSK-KNFYRNETSSQESKNLSTPGTR------VQARG 1514

Query: 122  RT-PGRRGSRSSKRSPSRASTPGRIRTHGARPGMASRVRTPTSQQKGSRGKSYGRPRTSN 180
            R  PG    R+  R      T    + H   P    R RTP    + +R     R   S 
Sbjct: 1515 RILPGSPVKRTWHRHLKDKLTH---KEHN-HPSFY-RERTPRGPSERTRHNPSWRNHRSP 1569

Query: 181  RERSDSQPRNLSKKSYRPPGGSGIGRSSELAVTPSTAKCQTPTGIPSKEKSDNPSPSSSR 240
             ERS  Q  +L ++ + P   S    S +   +PS    ++P    S+    +P   S  
Sbjct: 1570 SERS--QRSSLERRHHSPSQRSHCSPSRKNHSSPSERSWRSP----SQRNHCSPPERSCH 1623

Query: 241  KVKSYGQMIIPSREKSYSPTEMSSRVKSYNQASTRSRPQSHSQSRSPRRSRSGSQKRTHS 300
             +   G +  PS+     P++   R  S ++ S RS  +   +S S RR RS SQ R+H 
Sbjct: 1624 SLSERG-LHSPSQRSHRGPSQR--RHHSPSERSHRSPSERSHRSSSERRHRSPSQ-RSHR 1679

Query: 301  --RVRSHSW--KRNHSRARSRTRKGILSQMGRHSQSRSHSKGKSQNQSRTPRRGRSHNWS 356
                RSH    +R H     R+ +G        S+ R HS  K  +  R+P R RSH   
Sbjct: 1680 GPSERSHCSPSERRHRSPSQRSHRG-------PSERRHHSPSKRSH--RSPAR-RSH--- 1726

Query: 357  RNPSKERSHSHSRSSSKERDHRGSSSPRKESGRSQSGSPNKQRDHSRSRSPNKARDRSRS 416
            R+PS+   HS S  S      R   SP + S  S S   +      R RSP++ R  S S
Sbjct: 1727 RSPSERSHHSPSERSHHSPSERRHHSPSERSHCSPSERSHCSPSERRHRSPSERRHHSPS 1786

Query: 417  -RSPYKARDRSRSRSPNKARDCSRSRSPYKARDRSRSRSPNKARDHSRSRSPNKARDRSR 475
             +S +   +RS      + R     RS +   +RS  RSP++ R H RS   +  R   R
Sbjct: 1787 EKSHHSPSERSHHSPSERRRHSPLERSRHSLLERSH-RSPSERRSH-RSFERSHRRISER 1844

Query: 476  SRSPSKERDHSQLG----SPSKERDHRRSRSPSKERQCRQSRSSSKERDHRRSRSPSKER 531
            S SPS++   S L     SPS+ R H      S  + C     S  ER H   RSPS  R
Sbjct: 1845 SHSPSEKSHLSPLERSRCSPSERRGH-----SSSGKTCH----SPSERSH---RSPSGMR 1892

Query: 532  QRRQSRSPNKERDRSQSRSPSEEREHRQSRSPSKERDRRRWRSPSKERERRQSRSSSEER 591
            Q R S   ++        SPSE R  R S         R  RSP KE  +       E  
Sbjct: 1893 QGRTSERSHRSSCERTRHSPSEMRPGRPSGRNHCSPSERSRRSPLKEGLKYS--FPGERP 1950

Query: 592  DHSRSRSPNKQS 603
             HS SR    Q+
Sbjct: 1951 SHSLSRDFKNQT 1962


>gi|42542379 serine/arginine repetitive matrix 1 [Homo sapiens]
          Length = 904

 Score =  157 bits (398), Expect = 2e-38
 Identities = 191/731 (26%), Positives = 282/731 (38%), Gaps = 90/731 (12%)

Query: 3   SPKRSSKP-SMSLAPSGSSMPTADPKPPASLK--STKSATPNRSLVPTKPATSRNSVMSP 59
           SP+  +K  S S AP         P+P   +K  S + AT    ++             P
Sbjct: 200 SPRHRTKSRSPSPAPEKKEKTPELPEPSVKVKEPSVQEATSTSDILKVPKPEPIPEPKEP 259

Query: 60  SSSKSTKSTSTKRAPSNRPSSRSRVRSKARTPSRVSTDTRTSKASKASDVRCHQRRGTHS 119
           S  K++K    K     RP SRSR +S++RT SR  + TR  +           R  + S
Sbjct: 260 SPEKNSKKEKEKE--KTRPRSRSRSKSRSRTRSRSPSHTRPRR-----------RHRSRS 306

Query: 120 RGRTPGRRGSRSSKRSPSRASTPGRIRTHGARPGMASRVRTPTSQQKGSRGKSYGRPRTS 179
           R  +P RR S   + SP R + P R+      P    R R+P  +++ S     G   +S
Sbjct: 307 RSYSPRRRPSPRRRPSPRRRTPPRRMPP----PPRHRRSRSPVRRRRRSSASLSGSSSSS 362

Query: 180 NRERSDSQPRNLSKKSYRPPGGSGIGRSSELAVTPSTAKCQTPTGIPSKEKSDNPSPSSS 239
           +  RS S P+   K++  PP  +   R S  A  P      +P   P  +   +P+P  S
Sbjct: 363 SSSRSRSPPKKPPKRTSSPPRKTR--RLSPSASPPRRRHRPSPPATPPPKTRHSPTPQQS 420

Query: 240 RKVKSYGQMIIPSREKSYSPTEMSSRVKSYNQASTRSRPQSHSQSRSPRRSRSGSQKRTH 299
            + +            S SP   S +V  +     R  P    + R    S S   K   
Sbjct: 421 NRTRK--------SRVSVSPGRTSGKVTKHKGTEKRESPSPAPKPRKVELSESEEDKGGK 472

Query: 300 SRVRSHSWKRNHSRARSRTRKGILSQMGRHSQSRSHSKGKSQNQSRTPRRGRSHNWSRNP 359
                   +R   R +++             QS S S   S ++   P+R  SH  +   
Sbjct: 473 MAAADSVQQRRQYRRQNQ-------------QSSSDSGSSSSSEDERPKR--SHVKNGEV 517

Query: 360 SKERSHSHSRSSSKE-RDHRGSSSPRKESGRSQSGSPNKQRDHSRSRSPNKARDRSRSRS 418
            + R HS SRS+S   R  +  +SPR    RS S  P ++R     RSP+ A    R R+
Sbjct: 518 GRRRRHSPSRSASPSPRKRQKETSPRGRRRRSPSPPPTRRR-----RSPSPAPPPRRRRT 572

Query: 419 PYKA-RDRSRSRSPNKARDCSRSRSPYKARDRSRSRSPNKARDHSRSRSPNKARDRSRSR 477
           P    R R+ S  P +     R  SP   R  S S  P +     R+ SP     R  S 
Sbjct: 573 PTPPPRRRTPSPPPRRRSPSPRRYSPPIQRRYSPSPPPKR-----RTASPPPPPKRRASP 627

Query: 478 SPSKERDHSQLGSPSKERDHRRSRSPSKERQCRQSRSSSKERDHRRSRSPSKERQRRQSR 537
           SP  +R  S    P K+R    ++  S     +  + SS  R  R +RSP  +  +R S 
Sbjct: 628 SPPPKRRVSH-SPPPKQRSSPVTKRRSPSLSSKHRKGSSPSRSTREARSP--QPNKRHSP 684

Query: 538 SPNKERDRSQSRSP------SEEREHRQSRSPSKERDRRRWRSPS-KERERRQSRSSSEE 590
           SP     ++ S  P      S   + RQS SPS    RR  R+P  K+ ++  S S    
Sbjct: 685 SPRPRAPQTSSSPPPVRRGASSSPQRRQSPSPSTRPIRRVSRTPEPKKIKKAASPSPQSV 744

Query: 591 RDHSRSRSPNKQSGYSRPRASSKEKAHSRSRTPSKEGNHSQSRTSSKESDPSQS-TVPRS 649
           R  S SRS    SG   P A       S  ++ S   N S +    K   P+ S + PR+
Sbjct: 745 RRVSSSRS---VSGSPEPAAKKPPAPPSPVQSQSPSTNWSPAVPVKKAKSPTPSPSPPRN 801

Query: 650 PDW-----KRSPTRTSSLSQNRTPSKTSSH--------------SPSTFPSGGQTLSQDD 690
            D      K+   +     +++   K   H              +P+   +   TL+Q++
Sbjct: 802 SDQEGGGKKKKKKKDKKHKKDKKHKKHKKHKKEKAVAAAAAAAVTPAAIAAATTTLAQEE 861

Query: 691 SQADATTSKAT 701
             A     K T
Sbjct: 862 PVAAPEPKKET 872



 Score =  138 bits (348), Expect = 2e-32
 Identities = 178/650 (27%), Positives = 250/650 (38%), Gaps = 112/650 (17%)

Query: 115 RGTHSRGRTPGRRGSRSSKRSPSRASTP---GRIRTHGARPGMASRVRTPTSQQKGSRGK 171
           R    R R+P RR SRS   SP R S+P    R R+H   P   ++ R+P+         
Sbjct: 163 REKRERSRSPRRRKSRSP--SPRRRSSPVRRERKRSHSRSPRHRTKSRSPS--------- 211

Query: 172 SYGRPRTSNRERSDSQPRNLSKKSYRPPGGSGIGRSSELAVTPSTAKCQTPTGIPSKEKS 231
               P    +E++   P   S K   P          E   T    K   P  IP  ++ 
Sbjct: 212 ----PAPEKKEKTPELPEP-SVKVKEPS-------VQEATSTSDILKVPKPEPIPEPKE- 258

Query: 232 DNPSPSSSRKVKSYGQMIIPSREKSYSPTEMSSRVKSYNQASTRSRPQSHSQSRSPRRSR 291
             PSP  + K           +EK    T   SR +S +++ TRSR  SH++ R   RSR
Sbjct: 259 --PSPEKNSK-----------KEKEKEKTRPRSRSRSKSRSRTRSRSPSHTRPRRRHRSR 305

Query: 292 SG--SQKRTHSRVRSHSWKRNHSRARSRTRKGILSQMGRHSQSRSHSKGKSQNQSRTPRR 349
           S   S +R  S        R     R RT    +    RH +SRS  +          RR
Sbjct: 306 SRSYSPRRRPS-------PRRRPSPRRRTPPRRMPPPPRHRRSRSPVR----------RR 348

Query: 350 GRSHNWSRNPSKERSHSHSRSSSKERDHRGSSSPRKESGRSQSGSPNKQRD--------- 400
            RS       S   S S SRS  K+   R SS PRK    S S SP ++R          
Sbjct: 349 RRSSASLSGSSSSSSSSRSRSPPKKPPKRTSSPPRKTRRLSPSASPPRRRHRPSPPATPP 408

Query: 401 ----HSRS-RSPNKARDRSRSRSP---------YKARDRSRSRSP-NKARDCSRSRSPYK 445
               HS + +  N+ R    S SP         +K  ++  S SP  K R    S S   
Sbjct: 409 PKTRHSPTPQQSNRTRKSRVSVSPGRTSGKVTKHKGTEKRESPSPAPKPRKVELSESEED 468

Query: 446 ARDRSRSRSPNKARDHSRSRSPNKARDRSRSRSPSKE---RDHSQLGSPSKERDHRRSRS 502
              +  +    + R   R ++   + D   S S   E   R H + G   + R H  SRS
Sbjct: 469 KGGKMAAADSVQQRRQYRRQNQQSSSDSGSSSSSEDERPKRSHVKNGEVGRRRRHSPSRS 528

Query: 503 PSKERQCRQSRSSSKERDHRRSRSPSKERQRRQSRSPNKERDRS--------------QS 548
            S   + RQ  +S + R  R    P   R+R  S +P   R R+              + 
Sbjct: 529 ASPSPRKRQKETSPRGRRRRSPSPPPTRRRRSPSPAPPPRRRRTPTPPPRRRTPSPPPRR 588

Query: 549 RSPSEER-----EHRQSRSPSKERDRRRWRSPSKERERRQSRSSSEERDHSRSRSPNKQS 603
           RSPS  R     + R S SP     +RR  SP    +RR S S   +R  S S  P ++S
Sbjct: 589 RSPSPRRYSPPIQRRYSPSPP---PKRRTASPPPPPKRRASPSPPPKRRVSHSPPPKQRS 645

Query: 604 G-YSRPRASSKEKAHSRSRTPSKEGNHSQSRTSSKESDPSQSTVPRSPDWKRSPTRTSSL 662
              ++ R+ S    H +  +PS+    ++S   +K   PS    PR+P    SP      
Sbjct: 646 SPVTKRRSPSLSSKHRKGSSPSRSTREARSPQPNKRHSPSPR--PRAPQTSSSPPPVRR- 702

Query: 663 SQNRTPSKTSSHSPSTFPSGGQTLSQDDSQADATTSKATLPGERSSSSSS 712
             + +P +  S SPST P    + + +  +     S +     R SSS S
Sbjct: 703 GASSSPQRRQSPSPSTRPIRRVSRTPEPKKIKKAASPSPQSVRRVSSSRS 752



 Score =  128 bits (321), Expect = 2e-29
 Identities = 149/573 (26%), Positives = 232/573 (40%), Gaps = 50/573 (8%)

Query: 164 QQKGSRGKSYGRPRTSNRERSDSQPRNLSKKSYRPPGGSGIGRSSELAVTPSTAKCQTPT 223
           + K  R K         RERS S PR    +S  P       RSS +      +  ++P 
Sbjct: 149 EDKDKRDKEEKESSREKRERSRS-PRRRKSRSPSPRR-----RSSPVRRERKRSHSRSPR 202

Query: 224 GIPSKEKSDNPSPSSSRKVKSYGQMIIPSREKSYSPTEMSSRVKSYNQASTRSRPQSHSQ 283
              +K +S +P+P    K     +  +  +E S      +S +    +      P+  S 
Sbjct: 203 H-RTKSRSPSPAPEKKEKTPELPEPSVKVKEPSVQEATSTSDILKVPKPEPIPEPKEPSP 261

Query: 284 SRSPRRSRSGSQKRTHSRVRSHSWKRNHSRARSRTRKGILSQMGRHSQSRSHSKGKSQNQ 343
            ++ ++ +   + R  SR RS S  R  SR+ S TR     +    S+SRS+S  +  + 
Sbjct: 262 EKNSKKEKEKEKTRPRSRSRSKSRSRTRSRSPSHTRP----RRRHRSRSRSYSPRRRPSP 317

Query: 344 SRTPRRGRSHNWSRNPSKERSHSHSRSSSKERDHRGSSSPRKESGRSQSGSPNKQRDHSR 403
            R P   R     R P   R   H RS S  R  R SS+    S  S S S        R
Sbjct: 318 RRRPSPRRRTPPRRMPPPPR---HRRSRSPVRRRRRSSASLSGSSSSSSSS--------R 366

Query: 404 SRSPNKARDRSRSRSPYKARDRSRSRSP--NKARDCSRSRSPYKARDRSRSRSPNKARDH 461
           SRSP K   +  S  P K R  S S SP   + R    +  P K R     +  N+ R  
Sbjct: 367 SRSPPKKPPKRTSSPPRKTRRLSPSASPPRRRHRPSPPATPPPKTRHSPTPQQSNRTRKS 426

Query: 462 SRSRSP---------NKARDRSRSRSPSKERDHSQLGSPSKERDHRRSRSPSKERQCRQS 512
             S SP         +K  ++  S SP+ +    +L    +++  + + + S +++ +  
Sbjct: 427 RVSVSPGRTSGKVTKHKGTEKRESPSPAPKPRKVELSESEEDKGGKMAAADSVQQRRQYR 486

Query: 513 RSSSKERDHRRSRSPSKERQRRQSRSPNKERDRSQSRSPSEEREH--RQSRSPSKERDRR 570
           R + +      S S S++ + ++S   N E  R +  SPS       R+ +  +  R RR
Sbjct: 487 RQNQQSSSDSGSSSSSEDERPKRSHVKNGEVGRRRRHSPSRSASPSPRKRQKETSPRGRR 546

Query: 571 RWRSPSKERERRQSRSSSEERDHSRSRSPNKQSGYSRPRASSKEKAHSRSR-TPSKEGNH 629
           R RSPS    RR+ RS S      R R+P        P    + ++ S  R +P  +  +
Sbjct: 547 R-RSPSPPPTRRR-RSPSPAPPPRRRRTPTPPPRRRTPSPPPRRRSPSPRRYSPPIQRRY 604

Query: 630 SQS-----RTSSKESDPSQSTVPRSPDWKR---SPT---RTSSLSQNRTPSKTSSHSPST 678
           S S     RT+S    P +   P  P  +R   SP    R+S +++ R+PS +S H   +
Sbjct: 605 SPSPPPKRRTASPPPPPKRRASPSPPPKRRVSHSPPPKQRSSPVTKRRSPSLSSKHRKGS 664

Query: 679 FPSGGQTLSQDDSQADATTSKATLPGERSSSSS 711
            PS   T      Q +   S +  P    +SSS
Sbjct: 665 SPS-RSTREARSPQPNKRHSPSPRPRAPQTSSS 696



 Score =  113 bits (283), Expect = 5e-25
 Identities = 120/399 (30%), Positives = 172/399 (43%), Gaps = 71/399 (17%)

Query: 339 KSQNQSRTPRRGRSHNWSRNPSKERSHSHSRSSSKERDHRGSSSP-RKESGRSQSGSPNK 397
           K Q++ +  +R +    S    +ERS S  R  S+    R  SSP R+E  RS S SP  
Sbjct: 145 KKQDEDKD-KRDKEEKESSREKRERSRSPRRRKSRSPSPRRRSSPVRRERKRSHSRSP-- 201

Query: 398 QRDHSRSRSPNKARDRSRSRSP------YKARDRS--------------------RSRSP 431
            R  ++SRSP+ A ++ + ++P       K ++ S                      + P
Sbjct: 202 -RHRTKSRSPSPAPEK-KEKTPELPEPSVKVKEPSVQEATSTSDILKVPKPEPIPEPKEP 259

Query: 432 NKARDCSRSRSPYKARDRSRSRSPNKARDHSRSRSPN----KARDRSRSRSPSKERDHSQ 487
           +  ++  + +   K R RSRSRS  K+R  +RSRSP+    + R RSRSRS S  R  S 
Sbjct: 260 SPEKNSKKEKEKEKTRPRSRSRS--KSRSRTRSRSPSHTRPRRRHRSRSRSYSPRRRPSP 317

Query: 488 LGSPSKER-----------DHRRSRSPSKERQCRQSRS---SSKERDHRRSRSPSKERQR 533
              PS  R            HRRSRSP + R+ R S S   SS      RSRSP K+  +
Sbjct: 318 RRRPSPRRRTPPRRMPPPPRHRRSRSPVRRRR-RSSASLSGSSSSSSSSRSRSPPKKPPK 376

Query: 534 RQSRSPNKERDRSQSRSPSEEREHRQSRSPSKERDRRRWRSPSKERERRQS-------RS 586
           R S  P K R  S S SP   R HR S   +     R   +P +    R+S       R+
Sbjct: 377 RTSSPPRKTRRLSPSASP-PRRRHRPSPPATPPPKTRHSPTPQQSNRTRKSRVSVSPGRT 435

Query: 587 SSEERDHSRSRSPNKQSGYSRPR-----ASSKEKAHSRSRTPSKEGNHS---QSRTSSKE 638
           S +   H  +      S   +PR      S ++K    +   S +       Q++ SS +
Sbjct: 436 SGKVTKHKGTEKRESPSPAPKPRKVELSESEEDKGGKMAAADSVQQRRQYRRQNQQSSSD 495

Query: 639 SDPSQSTVPRSPDWKRSPTRTSSLSQNRTPSKTSSHSPS 677
           S  S S+    P  KRS  +   + + R  S + S SPS
Sbjct: 496 SGSSSSSEDERP--KRSHVKNGEVGRRRRHSPSRSASPS 532



 Score =  102 bits (254), Expect = 1e-21
 Identities = 101/330 (30%), Positives = 142/330 (43%), Gaps = 39/330 (11%)

Query: 397 KQRDHSRSRSPNKARDRSRSRSPYKARDRSRSRSPNKARDCSRSRSPYKARDRSRSRSPN 456
           K+    R     K     +       RD+    S  + R+  RSRSP     R +SRSP+
Sbjct: 128 KEEIKQRQIEQEKLASMKKQDEDKDKRDKEEKESSREKRE--RSRSPR----RRKSRSPS 181

Query: 457 KARDHSRSRSPNKARDRSRSRSPSKERDHSQLGSPSKERDHRRSRSPS-----KERQCRQ 511
             R   RS    + R RS SRSP + R  S+  SP+ E+  +    P      KE   ++
Sbjct: 182 PRR---RSSPVRRERKRSHSRSP-RHRTKSRSPSPAPEKKEKTPELPEPSVKVKEPSVQE 237

Query: 512 SRSSS------KERDHRRSRSPSKERQRRQSRSPNKERDRSQSRSPSEEREHRQSRSPSK 565
           + S+S      K       + PS E+  ++ +   K R RS+SRS S  R   +SRSPS 
Sbjct: 238 ATSTSDILKVPKPEPIPEPKEPSPEKNSKKEKEKEKTRPRSRSRSKS--RSRTRSRSPSH 295

Query: 566 ERDRRRWRSPSKERERRQSRSSSEERDHSRSRSPNKQSGYSRPRASSKEKAHSRSRTPSK 625
            R RRR RS S+    R+ R S   R   R R+P        PR       H RSR+P +
Sbjct: 296 TRPRRRHRSRSRSYSPRR-RPSPRRRPSPRRRTP--------PRRMPPPPRHRRSRSPVR 346

Query: 626 EGNHSQSRTSSKESDPSQSTVPRSPDWKRSPTRTSSLSQNRTPSKTSSHSPSTFPSGGQT 685
               S S + S  S  S S+  RSP  K+ P RTSS      P KT   SPS  P   + 
Sbjct: 347 RRRRS-SASLSGSSSSSSSSRSRSPP-KKPPKRTSS-----PPRKTRRLSPSASPPRRRH 399

Query: 686 LSQDDSQADATTSKATLPGERSSSSSSKLA 715
                +     T  +  P + + +  S+++
Sbjct: 400 RPSPPATPPPKTRHSPTPQQSNRTRKSRVS 429



 Score =  102 bits (254), Expect = 1e-21
 Identities = 116/394 (29%), Positives = 165/394 (41%), Gaps = 67/394 (17%)

Query: 361 KERSHSHSRSSSKERDHRGSSSPRKESGRSQSGSPNKQRDHSRSRSPNKARDRSRSRSPY 420
           K+R     + +S ++         KE    +  S  ++R+  RSRSP   R +SRS SP 
Sbjct: 132 KQRQIEQEKLASMKKQDEDKDKRDKE----EKESSREKRE--RSRSPR--RRKSRSPSP- 182

Query: 421 KARDRSRSRSPNKARDCSRSRSPYKARDRSRSRSPNKARDHSRSRSPNKARDRSRSRSPS 480
               R RS    + R  S SRSP   R R++SRSP+ A +  + ++P       + + PS
Sbjct: 183 ----RRRSSPVRRERKRSHSRSP---RHRTKSRSPSPAPE-KKEKTPELPEPSVKVKEPS 234

Query: 481 KERDHS--------------QLGSPSKERDHRRSRSPSKERQCRQSRSSSKERDHRRSRS 526
            +   S              +   PS E++ ++ +   K R   +SRS SK R   RSRS
Sbjct: 235 VQEATSTSDILKVPKPEPIPEPKEPSPEKNSKKEKEKEKTRP--RSRSRSKSRSRTRSRS 292

Query: 527 PSKERQRR----QSRSPNKERDRSQSRSPSEEREHRQSRSPSKERDRRRWRSPSKERERR 582
           PS  R RR    +SRS +  R  S  R PS  R     R P   R RR  RSP + R R 
Sbjct: 293 PSHTRPRRRHRSRSRSYSPRRRPSPRRRPSPRRRTPPRRMPPPPRHRRS-RSPVRRRRRS 351

Query: 583 QS--RSSSEERDHSRSRSPNKQSGYSRPRASSKEKAHSRSRTPSKEGNHSQSRTSSKESD 640
            +    SS     SRSRSP K+     P+ +S     +R  +PS      + R S   + 
Sbjct: 352 SASLSGSSSSSSSSRSRSPPKKP----PKRTSSPPRKTRRLSPSASPPRRRHRPSPPATP 407

Query: 641 PSQSTVPRSPDWKRSPTRTS--SLSQNRTPSKTSSH-------SPSTFP----------- 680
           P ++    +P  + + TR S  S+S  RT  K + H       SPS  P           
Sbjct: 408 PPKTRHSPTPQ-QSNRTRKSRVSVSPGRTSGKVTKHKGTEKRESPSPAPKPRKVELSESE 466

Query: 681 --SGGQTLSQDDSQADATTSKATLPGERSSSSSS 712
              GG+  + D  Q      +        S SSS
Sbjct: 467 EDKGGKMAAADSVQQRRQYRRQNQQSSSDSGSSS 500



 Score = 94.7 bits (234), Expect = 3e-19
 Identities = 129/558 (23%), Positives = 224/558 (40%), Gaps = 93/558 (16%)

Query: 2   SSPKRSSKPSMSLAPSGSSMPTADPKPPASLKSTKSATPNRSLVPTKPATSRNSVMSPSS 61
           S  +R  + S SL+ S SS  ++  + P      ++++P R      P+ S        S
Sbjct: 343 SPVRRRRRSSASLSGSSSSSSSSRSRSPPKKPPKRTSSPPRKTRRLSPSASPPRRRHRPS 402

Query: 62  SKSTKSTSTKRAPSNRPSSRSRVRSKARTPSRVSTDTRTSKASKASDVRCHQRRGTHSRG 121
             +T    T+ +P+ + S+R+R    + +P R S      K +K         +GT  R 
Sbjct: 403 PPATPPPKTRHSPTPQQSNRTRKSRVSVSPGRTS-----GKVTK--------HKGTEKR- 448

Query: 122 RTPGRRGSRSSKRSPSRASTPGRIRTHGARPGMASRVRTPTSQQKGSRGKSYGRPRTSNR 181
                        SPS A  P ++    +      ++    S Q+  + +   +  +S+ 
Sbjct: 449 ------------ESPSPAPKPRKVELSESEEDKGGKMAAADSVQQRRQYRRQNQQSSSDS 496

Query: 182 ERSDSQPRNLSKKSYRPPGGSGIGR--SSELAVTPSTAKCQTPTGIPSKEKSDNPSPSSS 239
             S S      K+S+   G  G  R  S   + +PS  K Q  T  P   +  +PSP  +
Sbjct: 497 GSSSSSEDERPKRSHVKNGEVGRRRRHSPSRSASPSPRKRQKETS-PRGRRRRSPSPPPT 555

Query: 240 RKVKSYGQMIIPSREKSYSPTEMSSRVKSYNQASTRSRPQSHSQSRSPRRSRSGSQKRTH 299
           R+ +S      P R ++ +P                  P+  + S  PRR RS S +R  
Sbjct: 556 RRRRSPSPAPPPRRRRTPTPP-----------------PRRRTPSPPPRR-RSPSPRRYS 597

Query: 300 SRVRSHSWKRNHSRARSRTRKGILSQMGRHSQSRSHSKGKSQNQSRTPRRGRSHNWSRNP 359
             +     +R +S +    R+         + S      +  + S  P+R  SH+    P
Sbjct: 598 PPI-----QRRYSPSPPPKRR---------TASPPPPPKRRASPSPPPKRRVSHS---PP 640

Query: 360 SKERSH--SHSRSSSKERDHRGSSSPRKESGRSQSGSPNKQRDHS-RSRSPNKARD---- 412
            K+RS   +  RS S    HR  SSP + +  ++S  PNK+   S R R+P  +      
Sbjct: 641 PKQRSSPVTKRRSPSLSSKHRKGSSPSRSTREARSPQPNKRHSPSPRPRAPQTSSSPPPV 700

Query: 413 -RSRSRSPYKARDRSRSRSPNKARDCSRSRSPYKARDRSRSRSPNKARDHSRSRSPNKAR 471
            R  S SP + +  S S  P   R  SR+  P K + ++ S SP   R  S SRS + + 
Sbjct: 701 RRGASSSPQRRQSPSPSTRP--IRRVSRTPEPKKIK-KAASPSPQSVRRVSSSRSVSGSP 757

Query: 472 DRSRSR-----SPSKERDHSQLGSPSKERDHRRSRSPS-------------KERQCRQSR 513
           + +  +     SP + +  S   SP+      +S +PS             K+++ ++ +
Sbjct: 758 EPAAKKPPAPPSPVQSQSPSTNWSPAVPVKKAKSPTPSPSPPRNSDQEGGGKKKKKKKDK 817

Query: 514 SSSKERDHRRSRSPSKER 531
              K++ H++ +   KE+
Sbjct: 818 KHKKDKKHKKHKKHKKEK 835


>gi|88501738 TRIO and F-actin binding protein isoform 6 [Homo
           sapiens]
          Length = 2365

 Score =  155 bits (393), Expect = 9e-38
 Identities = 175/713 (24%), Positives = 305/713 (42%), Gaps = 116/713 (16%)

Query: 39  TPNRSLVPTKPATSRNSVMSPSSSKSTKSTSTKRAPSNRPSSRSRVRSKARTPSRVSTDT 98
           T   S+ P     S  S  SP+   + ++ ST+  P  R SS  R+    R  SR S+  
Sbjct: 241 TQASSMTPHSGPRSTTSQASPAQRDTAQAASTREIP--RASSPHRITQ--RDTSRASSTQ 296

Query: 99  RTSKASKASDVRCHQRRGTHSRGRTPGRRGSRSSKRSPSRASTPGRIRTHGARPGMASRV 158
           +  + S+AS  +    R + ++  TP  R S + + +P  +ST               + 
Sbjct: 297 Q--EISRASSTQQETSRASSTQEDTP--RASSTQEDTPRASST---------------QW 337

Query: 159 RTPTSQQKGSRGKSYGRPRTSNRERSDSQPRNLSKKSYRPPGGSGIGRSSELAVTPSTAK 218
            TP +    SR      PRTS+ ++ + Q                   +S    TP    
Sbjct: 338 NTPRASSP-SRSTQLDNPRTSSTQQDNPQ-------------------TSFPTCTPQREN 377

Query: 219 CQTPTGIPSKEKSDNPSPSSSRKVK--SYGQMIIPSREKSYSPTEMSSRVKSYNQASTRS 276
            +TP       ++ +P+ ++ R+    S  Q   P   ++ SP   ++R       + R 
Sbjct: 378 PRTPCVQQDDPRASSPNRTTQRENSRTSCAQRDNPKASRTSSPNR-ATRDNPRTSCAQRD 436

Query: 277 RPQSHSQSR--------------SPRRSRSGSQKR-THSRVRSHSWKRNHSRARSRTRKG 321
            P++ S SR              +PR SR+ S  R T    R+   +R++ RA S +R  
Sbjct: 437 NPRASSPSRATRDNPTTSCAQRDNPRASRTSSPNRATRDNPRTSCAQRDNPRASSPSR-- 494

Query: 322 ILSQMGRHSQSRSHSKGKSQNQSRTPRRGRSHNWSRNPSKERSHSHSRSSSKERDHRGSS 381
                 R + + S ++  +   SRT    R+           +  + R+S  +RD+  +S
Sbjct: 495 ----ATRDNPTTSCAQRDNPRASRTSSPNRA-----------TRDNPRTSCAQRDNPRAS 539

Query: 382 SPRKESGRSQSGSPNKQRDH---SRSRSPNKARDRSRSRSPYKARDRSRSRSPNKA-RDC 437
           SP + + R    +   QRD+   SR+ SPN+A  R   R+    RD  R+ SPN+A RD 
Sbjct: 540 SPNR-AARDNPTTSCAQRDNPRASRTSSPNRA-TRDNPRTSCAQRDNPRASSPNRATRDN 597

Query: 438 SRSRSPYKARDR-SRSRSPNKA-----------RDHSRSRSPNKARDRSRSRSPSKERDH 485
             +    +   R SR+ SPN+A           RD+ R+ SPN+   +   R+    RD 
Sbjct: 598 PTTSCAQRDNPRASRTSSPNRATRDNPRTSCAQRDNPRASSPNRTTQQDSPRTSCARRDD 657

Query: 486 SQLGSPSKE------------RDHRRSRSPSKERQCRQSRSSSKERDHRRSRSPSKERQR 533
            +  SP++             RD+ R+ SPS+  Q    R+S  +RD  R+ SP++  Q+
Sbjct: 658 PRASSPNRTIQQENPRTSCALRDNPRASSPSRTIQQENPRTSCAQRDDPRASSPNRTTQQ 717

Query: 534 RQSRSPNKERDRSQSRSPSEEREHRQSRSPSKERDRRRWRSPSKERERRQSRSSSEERDH 593
              R+    RD  ++ S +   +    R+   +RD  R  SP++  ++   R+S   +D+
Sbjct: 718 ENPRTSCARRDNPRASSRNRTIQRDNPRTSCAQRDNPRASSPNRTIQQENLRTSCTRQDN 777

Query: 594 SRSRSPNKQSGYSRPRASSKEKAHSRSRTPSKEGNHSQSRTSSKESDPSQSTV----PRS 649
            R+ SPN+ +    PR S  ++ + R+ +P +       RT  +++ P  S+     P++
Sbjct: 778 PRTSSPNRAT-RDNPRTSCAQRDNLRASSPIRATQQDNPRTCIQQNIPRSSSTQQDNPKT 836

Query: 650 PDWKRSPTRTSSLSQNRTPS-KTSSHSPSTFPSGGQTLSQDDSQADATTSKAT 701
              KR   R +   ++RT S      +P T  S  Q  +Q ++   ++  ++T
Sbjct: 837 SCTKRDNLRPTCTQRDRTQSFSFQRDNPGT--SSSQCCTQKENLRPSSPHRST 887



 Score =  154 bits (390), Expect = 2e-37
 Identities = 180/678 (26%), Positives = 290/678 (42%), Gaps = 83/678 (12%)

Query: 86  SKARTPSRVSTDTRTSKASKASDVRCHQRRGTHSRGRTPGRRGSR--SSKRSPSRASTPG 143
           ++ R  S +S +   S  ++AS +  H    + +   +P +R +   +S R   RAS+P 
Sbjct: 223 ARLRGESGLSLERHRSTLTQASSMTPHSGPRSTTSQASPAQRDTAQAASTREIPRASSPH 282

Query: 144 RIR---THGARPGMASRVRTPTSQQKGSRGKSYGRPRTSNRERSDSQPRNLSKKSYRPPG 200
           RI    T  A        R  ++QQ+ SR  S            +  PR  S   +  P 
Sbjct: 283 RITQRDTSRASSTQQEISRASSTQQETSRASSTQEDTPRASSTQEDTPR-ASSTQWNTPR 341

Query: 201 GSGIGRSSELAVTPSTAKCQTPTGIPSKEKSDNPSPSSSRKVKSYGQMIIPSREKSYSPT 260
            S   RS++L   P T+  Q           DNP  S             P RE   +P 
Sbjct: 342 ASSPSRSTQLD-NPRTSSTQ----------QDNPQTSFPT--------CTPQRENPRTPC 382

Query: 261 EMSS--RVKSYNQASTRSRPQ-SHSQSRSPRRSRSGSQKR-THSRVRSHSWKRNHSRARS 316
                 R  S N+ + R   + S +Q  +P+ SR+ S  R T    R+   +R++ RA S
Sbjct: 383 VQQDDPRASSPNRTTQRENSRTSCAQRDNPKASRTSSPNRATRDNPRTSCAQRDNPRASS 442

Query: 317 RTRKGILSQMGRHSQSRSHSKGKSQNQSRT--PRRGRSHNWSRNPSKERSHSHSRSSSKE 374
            +R        R + + S ++  +   SRT  P R    N  R    +R +  + S S+ 
Sbjct: 443 PSRAT------RDNPTTSCAQRDNPRASRTSSPNRATRDN-PRTSCAQRDNPRASSPSRA 495

Query: 375 -RDHRGSSSPRKESGR-SQSGSPNK-----------QRDHSRSRSPNKA-RDRSRSRSPY 420
            RD+  +S  ++++ R S++ SPN+           QRD+ R+ SPN+A RD   +    
Sbjct: 496 TRDNPTTSCAQRDNPRASRTSSPNRATRDNPRTSCAQRDNPRASSPNRAARDNPTTSCAQ 555

Query: 421 KARDR-SRSRSPNKA-RDCSRSRSPYKARDRSRSRSPNKA-RDH-------------SRS 464
           +   R SR+ SPN+A RD    R+    RD  R+ SPN+A RD+             SR+
Sbjct: 556 RDNPRASRTSSPNRATRD--NPRTSCAQRDNPRASSPNRATRDNPTTSCAQRDNPRASRT 613

Query: 465 RSPNKA-----------RDRSRSRSPSKERDHSQLGSPSKERDHRRSRSPSKERQCRQSR 513
            SPN+A           RD  R+ SP++        +    RD  R+ SP++  Q    R
Sbjct: 614 SSPNRATRDNPRTSCAQRDNPRASSPNRTTQQDSPRTSCARRDDPRASSPNRTIQQENPR 673

Query: 514 SSSKERDHRRSRSPSKERQRRQSRSPNKERDRSQSRSPSEEREHRQSRSPSKERDRRRWR 573
           +S   RD+ R+ SPS+  Q+   R+   +RD  ++ SP+   +    R+    RD  R  
Sbjct: 674 TSCALRDNPRASSPSRTIQQENPRTSCAQRDDPRASSPNRTTQQENPRTSCARRDNPRAS 733

Query: 574 SPSKERERRQSRSSSEERDHSRSRSPNKQSGYSRPRASSKEKAHSRSRTPSKEGNHSQSR 633
           S ++  +R   R+S  +RD+ R+ SPN+       R S   + + R+ +P++       R
Sbjct: 734 SRNRTIQRDNPRTSCAQRDNPRASSPNRTIQQENLRTSCTRQDNPRTSSPNR-ATRDNPR 792

Query: 634 TSSKESDPSQSTVPRSPDWKRSPTRTSSLSQNRTPSKTSSHSPSTFPSGGQTLSQDDSQA 693
           TS  + D  +++ P     + +P RT         S T   +P T  +    L    +Q 
Sbjct: 793 TSCAQRDNLRASSPIRATQQDNP-RTCIQQNIPRSSSTQQDNPKTSCTKRDNLRPTCTQR 851

Query: 694 DATTSKATLPGERSSSSS 711
           D T S +       +SSS
Sbjct: 852 DRTQSFSFQRDNPGTSSS 869



 Score =  151 bits (381), Expect = 2e-36
 Identities = 175/740 (23%), Positives = 305/740 (41%), Gaps = 80/740 (10%)

Query: 2   SSPKRSSKPSMSLAPSGSSMPTADPKPPASL---KSTKSATPNRSLVPTKPATSRNSVMS 58
           S+ + +S+ S +   +  +  T +  P AS     + ++++P+RS     P TS     +
Sbjct: 304 STQQETSRASSTQEDTPRASSTQEDTPRASSTQWNTPRASSPSRSTQLDNPRTSSTQQDN 363

Query: 59  PSSSKST-----KSTSTKRAPSNRPSSRSRVRSKARTPSRVSTDTRTS-KASKASDVRCH 112
           P +S  T     ++  T     + P + S  R+  R  SR S   R + KAS+ S     
Sbjct: 364 PQTSFPTCTPQRENPRTPCVQQDDPRASSPNRTTQRENSRTSCAQRDNPKASRTSS---- 419

Query: 113 QRRGTHSRGRTPGRRGSRSSKRSPSRASTPGRIRTHGARPGMASRVRTPTSQQKGSRGKS 172
             R T    RT        ++R   RAS+P R          A R     S+       +
Sbjct: 420 PNRATRDNPRTS------CAQRDNPRASSPSRATRDNPTTSCAQRDNPRASRTSSPNRAT 473

Query: 173 YGRPRTSNRERSDSQPRNLSKKSYRPPGGSGIGRSSELAVTPSTAKCQTPTGIPSKEKSD 232
              PRTS  +R + +  + S+ +   P  S   R +  A         + T  P++   D
Sbjct: 474 RDNPRTSCAQRDNPRASSPSRATRDNPTTSCAQRDNPRA---------SRTSSPNRATRD 524

Query: 233 NPSPSSSRKVKSYGQMIIPSREKSYSPTEMSSRVKSYNQASTRSRPQSHSQSRSPRRSRS 292
           NP  S +++                     + R  S N+A+  +   S +Q  +PR SR+
Sbjct: 525 NPRTSCAQRD--------------------NPRASSPNRAARDNPTTSCAQRDNPRASRT 564

Query: 293 GSQKR-THSRVRSHSWKRNHSRARSRTRKG------ILSQMGRHSQSRSHSKGKS-QNQS 344
            S  R T    R+   +R++ RA S  R          +Q      SR+ S  ++ ++  
Sbjct: 565 SSPNRATRDNPRTSCAQRDNPRASSPNRATRDNPTTSCAQRDNPRASRTSSPNRATRDNP 624

Query: 345 RTPRRGRSHNWSRNPSKERSHSHSRSSSKERDHRGSSSPRKESGRSQSGSPNKQRDHSRS 404
           RT    R +  + +P++       R+S   RD   +SSP +   +    +    RD+ R+
Sbjct: 625 RTSCAQRDNPRASSPNRTTQQDSPRTSCARRDDPRASSPNRTIQQENPRTSCALRDNPRA 684

Query: 405 RSPNKARDRSRSRSPYKARDRSRSRSPNKARDCSRSRSPYKARDRSRSRSPNKARDHSRS 464
            SP++   +   R+    RD  R+ SPN+       R+    RD  R+ S N+       
Sbjct: 685 SSPSRTIQQENPRTSCAQRDDPRASSPNRTTQQENPRTSCARRDNPRASSRNRTIQRDNP 744

Query: 465 RSPNKARDRSRSRSPSKERDHSQLGSPSKERDHRRSRSPSKERQCRQSRSSSKERDHRRS 524
           R+    RD  R+ SP++      L +    +D+ R+ SP++  +    R+S  +RD+ R+
Sbjct: 745 RTSCAQRDNPRASSPNRTIQQENLRTSCTRQDNPRTSSPNRATR-DNPRTSCAQRDNLRA 803

Query: 525 RSPSKERQRRQSRS---PNKERDRS-QSRSPSEEREHRQSRSPS-KERDRRRWRSPSKER 579
            SP +  Q+   R+    N  R  S Q  +P      R +  P+  +RDR +  S  ++ 
Sbjct: 804 SSPIRATQQDNPRTCIQQNIPRSSSTQQDNPKTSCTKRDNLRPTCTQRDRTQSFSFQRDN 863

Query: 580 ERRQSRSSSEERDHSRSRSPNKQSGYSRPRASSKEK-------AHSRSRTPSKEGNHSQS 632
               S     ++++ R  SP++ + ++ PR SS  +       A    R    +G  + S
Sbjct: 864 PGTSSSQCCTQKENLRPSSPHRSTQWNNPRNSSPHRTNKDIPWASFPLRPTQSDGPRTSS 923

Query: 633 RTSSKESDPSQSTVPRSPDWKRSPTRTSSLSQNRTPSKTSSHSPSTFPSGGQTLSQDDSQ 692
            + SK+S+   +++   P     P       Q  +PS+ + H P    S G T     S+
Sbjct: 924 PSRSKQSEVPWASIALRPTQGDRP-------QTSSPSRPAQHDPPQ-SSFGPTQYNLPSR 975

Query: 693 ADATTSKATLPGERSSSSSS 712
           A   TS +  PG +S+S +S
Sbjct: 976 A---TSSSHNPGHQSTSRTS 992



 Score = 37.4 bits (85), Expect = 0.049
 Identities = 72/306 (23%), Positives = 104/306 (33%), Gaps = 38/306 (12%)

Query: 380  SSSPRKESGRSQSGSPNKQRDHSRSRSPNKARDRSRSRSPYKARDRSRSRSPNKARDCS- 438
            S SP    G   S  P + R +          D    R       R   R P     CS 
Sbjct: 1243 SPSPGSSGGSRGSAPPGETRHNLEREEYTVLADLPPPR-------RLAQRQPGPQAQCSS 1295

Query: 439  --RSRSPYKARDRSRSRSPNKARDHSRSRSPNKARDRSRSRSPSKERDHSQLGSPSKERD 496
              R+ SP +A      R   + R  S +    +A+D  RS+ PS+ +        S    
Sbjct: 1296 GGRTHSPGRAEVE---RLFGQERRKSEAAGAFQAQDEGRSQQPSQGQSQLLRRQSSPAPS 1352

Query: 497  HRRSRSPSKERQCRQSRSSSKERDHRRS--RSPSKERQRRQSRSPNKERDRSQSRSPSEE 554
             + +  P+K  Q   +R S  E  H  S  + P  +RQ + S  P     R+ +R+P  E
Sbjct: 1353 RQVTMLPAK--QAELTRRSQAEPPHPWSPEKRPEGDRQLQGSPLP----PRTSARTP--E 1404

Query: 555  REHRQSRSPSKERDRRRWRSPSKERERRQSRSSSEERDHSRSRSPNKQSGYSRPRASSKE 614
            RE R  R    E  +   R P    + ++    S+       RS + Q G   P      
Sbjct: 1405 RELRTQR--PLESGQAGPRQPLGVWQSQEEPPGSQGPHRHLERSWSSQEGGLGPGGWWGC 1462

Query: 615  KAHSRSRTPSKEGNHSQSRTSSKESDPSQSTVPRSPDWKRSPTRTSSLSQNRTPSKTSSH 674
               S     + EG    +    KES            W+  PT       +  P +    
Sbjct: 1463 GEPSLGAAKAPEGAWGGTSREYKESWGQPEA------WEEKPT-------HELPRELGKR 1509

Query: 675  SPSTFP 680
            SP T P
Sbjct: 1510 SPLTSP 1515


>gi|116008442 zinc finger CCCH-type containing 13 [Homo sapiens]
          Length = 1564

 Score =  155 bits (391), Expect = 2e-37
 Identities = 186/732 (25%), Positives = 290/732 (39%), Gaps = 100/732 (13%)

Query: 2   SSPKRSSKPSMSLAPSGSSMPTADPKPPASLKSTKSATPNRSLVPT---------KPATS 52
           SSPK SS        S  S P  D +  +    +K   P     P          K    
Sbjct: 223 SSPKSSSASKKDRKTSAVSSPLLDQQRNSKTNQSKKKGPRTPSPPPPIPEDIALGKKYKE 282

Query: 53  RNSVMSPSSSKSTKSTSTKRAPSNRPSSRSRVRSKA---RTPSRVSTDTRTSKASKASDV 109
           +  V      K+       R    +   R + RS +   +  S +S+   +S +   S +
Sbjct: 283 KYKVKDRIEEKTRDGKDRGRDFERQREKRDKPRSTSPAGQHHSPISSRHHSSSSQSGSSI 342

Query: 110 RCH----QRRGTHS----RGRTPGRRGSRS-----SKRSPSRASTPGRIRTHGARPGMAS 156
           + H    +R+ T S    R  TP  R S S     S  SP R  +P R R+     G   
Sbjct: 343 QRHSPSPRRKRTPSPSYQRTLTPPLRRSASPYPSHSLSSPQRKQSPPRHRSPMREKGRHD 402

Query: 157 RVRTPTS------QQKGSRGKSYGRPRTSNRERSDSQPRNLSKKSYRPPGGSGIGRSSEL 210
             RT  S      +++ +RGK   R + S  ER   Q ++ S + +R       GR    
Sbjct: 403 HERTSQSHDRRHERREDTRGKR-DREKDSREEREYEQDQS-SSRDHRDDREPRDGRDRRD 460

Query: 211 AVTPSTAKCQTPTGIPSKEKSDNPSPSSSRKVKSYGQMIIPSREKSYSPTEMSSRVKSYN 270
           A      +          E  D+     SR+++ Y +    SR+    P +  S   +++
Sbjct: 461 ARDTRDRR----------ELRDSRDMRDSREMRDYSRDTKESRD----PRDSRSTRDAHD 506

Query: 271 QASTRSRPQSHSQSRSPRRSRSGSQK-----------RTHSRVRSHSWKRNHSRARSRTR 319
                 R     +   P  SRS  +            R  SR  S S  RN    RSR R
Sbjct: 507 YRDREGRDTHRKEDTYPEESRSYGRNHLREESSRTEIRNESRNESRSEIRNDRMGRSRGR 566

Query: 320 KGILSQMG----RHSQSRSHSKGKS-----QNQSRTPRRGR-----SHNWSRNPSKERSH 365
              L + G    R SQ  SHS   +     + +S  P R R     + + +R+ S ER H
Sbjct: 567 VPELPEKGSRGSRGSQIDSHSSNSNYHDSWETRSSYPERDRYPERDNRDQARDSSFERRH 626

Query: 366 SH-SRSSSKERDHRGSSSPRKESGRSQSGSPNKQRDHSR-----SRSPNKARDRSRSRSP 419
               R  ++ERD R  SSP +  GR+     +++R+  R      R   +AR+R R R  
Sbjct: 627 GERDRRDNRERDQR-PSSPIRHQGRNDELERDERREERRVDRVDDRRDERARERDRERER 685

Query: 420 YKARDRSRSRSPNKARDCSRSRSPYKARDRSRSRSPNKARDHSRSRSPNKARDRSRSRSP 479
            + R+R R R  ++ R+  R     +AR+R R R   + R+  R R  ++ R+R R R  
Sbjct: 686 DRERERERERERDREREKERELERERAREREREREKERDRERDRDRDHDRERERERERDR 745

Query: 480 SKERDHSQLGSPSKERDHRRSRSPSKERQCRQSRSSSKERDHRRSRSPSKERQRRQSRSP 539
            KER+  +     +ER+  R R   +ER+        +ER+  R+R   KER+R++    
Sbjct: 746 EKERERER-----EERERERERERERERE--------RERERERARERDKERERQRDWE- 791

Query: 540 NKERDRSQSRSPSEE-REHRQSRSPSKER-DRRRWR---SPSKERERRQSRSSSEERDHS 594
           +K++ R   R   EE RE R  R    ER  ++R+R   SPS  +  ++ R  S + D  
Sbjct: 792 DKDKGRDDRREKREEIREDRNPRDGHDERKSKKRYRNEGSPSPRQSPKRRREHSPDSDAY 851

Query: 595 RSRSPNKQSGYSRPRASSKEKAHSRSRTPSKEGNHSQSRTSSKESDPSQSTVPRSPDWKR 654
            S     +    R  +       SRS +PS      Q R   ++  P +    R  + + 
Sbjct: 852 NSGDDKNEK--HRLLSQVVRPQESRSLSPSHLTEDRQGRWKEEDRKPERKESSRRYEEQE 909

Query: 655 SPTRTSSLSQNR 666
              + SS+ + R
Sbjct: 910 LKEKVSSVDKQR 921



 Score =  147 bits (370), Expect = 4e-35
 Identities = 183/713 (25%), Positives = 274/713 (38%), Gaps = 83/713 (11%)

Query: 57  MSPSSSKSTKSTSTKRAPSNRPSSRSRVRSKARTPSRVSTDTRTSKASKASDVRCHQRRG 116
           +SP   +S  S S    PS R SS+S  R  +  P   S   +  K S  S     Q+R 
Sbjct: 197 VSPEVVRSKLSPS----PSLRKSSKSPKRKSS--PKSSSASKKDRKTSAVSSPLLDQQR- 249

Query: 117 THSRGRTPGRRGSRSSKRSPSRASTPGRIRTHGARPGMASRVRTPTSQQKGSRGKSYGRP 176
            +S+     ++G R+    P         + +  +  +  R+   T   K  RG+ + R 
Sbjct: 250 -NSKTNQSKKKGPRTPSPPPPIPEDIALGKKYKEKYKVKDRIEEKTRDGK-DRGRDFERQ 307

Query: 177 RTSNRERSDSQP--RNLSKKSYRPPGGSGIGRSSELAVTPSTAKCQTP------TGIPSK 228
           R    +   + P  ++ S  S R    S    SS    +PS  + +TP      T  P  
Sbjct: 308 REKRDKPRSTSPAGQHHSPISSRHHSSSSQSGSSIQRHSPSPRRKRTPSPSYQRTLTPPL 367

Query: 229 EKSDNPSPSSS----RKVKSYGQMIIPSREKS---YSPTEMSSRVKSYNQASTRSRPQSH 281
            +S +P PS S    ++ +S  +   P REK    +  T  S   +   +  TR +    
Sbjct: 368 RRSASPYPSHSLSSPQRKQSPPRHRSPMREKGRHDHERTSQSHDRRHERREDTRGKRDRE 427

Query: 282 SQSRSPRR-SRSGSQKRTHSRVRSHSWKRNHSRAR-SRTRKGILSQMGRHSQSRSHSKGK 339
             SR  R   +  S  R H   R     R+   AR +R R+ +                +
Sbjct: 428 KDSREEREYEQDQSSSRDHRDDREPRDGRDRRDARDTRDRRELRDSRDMRDSREMRDYSR 487

Query: 340 SQNQSRTPRRGRS----HNWSRNPSKERSHSHSRSSSKERDHRGSSSPRKESGRSQSGSP 395
              +SR PR  RS    H++     ++ +H    +  +E    G +  R+ES R++    
Sbjct: 488 DTKESRDPRDSRSTRDAHDYRDREGRD-THRKEDTYPEESRSYGRNHLREESSRTEIR-- 544

Query: 396 NKQRDHSRSRSPNKARDRSRSRSPYKARDRSRSR---------SPNKARDCSRSRSPYKA 446
           N+ R+ SRS   N    RSR R P      SR           S +   D   +RS Y  
Sbjct: 545 NESRNESRSEIRNDRMGRSRGRVPELPEKGSRGSRGSQIDSHSSNSNYHDSWETRSSYPE 604

Query: 447 RDRSRSR-SPNKARDHS-------RSRSPNKARD-------RSRSRSPSKERDHSQ---- 487
           RDR   R + ++ARD S       R R  N+ RD       R + R+   ERD  +    
Sbjct: 605 RDRYPERDNRDQARDSSFERRHGERDRRDNRERDQRPSSPIRHQGRNDELERDERREERR 664

Query: 488 LGSPSKERDHR-RSRSPSKERQCRQSRSSSKERDHRR--SRSPSKERQRRQSRSPNKERD 544
           +      RD R R R   +ER   + R   +ERD  R   R   +ER R + R   KERD
Sbjct: 665 VDRVDDRRDERARERDRERERDRERERERERERDREREKERELERERAREREREREKERD 724

Query: 545 RSQSRSPSEEREHRQSRSPSKERDRRRWRSPSKERERRQSRSSSEERDHSRSRSPNKQSG 604
           R + R    +RE  + R   +E++R R R   +ERER + R    ER+  R R       
Sbjct: 725 RERDRDRDHDRERERERERDREKERERER---EERERERERERERERERERERE------ 775

Query: 605 YSRPRASSKEKAHSRSRTPSKEGNHSQSRTSSKESDPSQSTVPRSPDWKRSPTR---TSS 661
               RA  ++K   R R    +      R   +E            D ++S  R     S
Sbjct: 776 ----RARERDKERERQRDWEDKDKGRDDRREKREEIREDRNPRDGHDERKSKKRYRNEGS 831

Query: 662 LSQNRTPSKTSSHSPSTFPSGGQTLSQDDSQADATTSKATLPGERSSSSSSKL 714
            S  ++P +   HSP    S       D ++     S+   P E  S S S L
Sbjct: 832 PSPRQSPKRRREHSPD---SDAYNSGDDKNEKHRLLSQVVRPQESRSLSPSHL 881



 Score =  123 bits (308), Expect = 7e-28
 Identities = 179/825 (21%), Positives = 296/825 (35%), Gaps = 142/825 (17%)

Query: 7    SSKPSMSLAPSGSSMPTADPKPPASLKSTKSATPNRSLVPTKPATSRNSVMSPSSSKSTK 66
            SS+   S + SGSS+    P P    K T S +  R+L P    ++     SP  S S  
Sbjct: 328  SSRHHSSSSQSGSSIQRHSPSPRR--KRTPSPSYQRTLTPPLRRSA-----SPYPSHSLS 380

Query: 67   STSTKRAPSNRPSSRSRVRSKARTPSRVSTDTRTSKASKASDVRCHQRRGTHSRGRTPGR 126
            S   K++P   P  RS +R K R     ++ +   +  +  D R  + R   SR      
Sbjct: 381  SPQRKQSP---PRHRSPMREKGRHDHERTSQSHDRRHERREDTRGKRDREKDSREEREYE 437

Query: 127  RGSRSSK-RSPSRASTPGRIRTHGARPGMASRVRTPTSQQKGSRGKSYGRPRTSNRERSD 185
            +   SS+     R    GR R           +R     +     + Y R    +R+  D
Sbjct: 438  QDQSSSRDHRDDREPRDGRDRRDARDTRDRRELRDSRDMRDSREMRDYSRDTKESRDPRD 497

Query: 186  SQPRNLSKKSYRPPGGSGIGRSSELAVTPSTA-------KCQTPTGIPSKEKSDNPSP-S 237
            S+        YR   G    R  +     S +       +  + T I ++ ++++ S   
Sbjct: 498  SRSTR-DAHDYRDREGRDTHRKEDTYPEESRSYGRNHLREESSRTEIRNESRNESRSEIR 556

Query: 238  SSRKVKSYGQMIIPSREKSYSPTEMSSRVKSYNQAST-----RSRPQSHSQSRSPRRSRS 292
            + R  +S G+  +P   +  S     S++ S++  S       +R     + R P R   
Sbjct: 557  NDRMGRSRGR--VPELPEKGSRGSRGSQIDSHSSNSNYHDSWETRSSYPERDRYPERDNR 614

Query: 293  GSQKRTHSRVRSHSWK-RNHSRARSRTRKGILSQMGRHSQ--------SRSHSKGKSQNQ 343
              Q R  S  R H  + R  +R R +     +   GR+ +         R   +   +  
Sbjct: 615  -DQARDSSFERRHGERDRRDNRERDQRPSSPIRHQGRNDELERDERREERRVDRVDDRRD 673

Query: 344  SRTPRRGRSHNWSRNPSKERSHSHSRSSSKERDHRGSSSPRKESGRSQSGSP--NKQRDH 401
             R   R R     R   +ER     R   KER+     +  +E  R +      ++ RDH
Sbjct: 674  ERARERDRERERDRERERERERERDREREKERELERERAREREREREKERDRERDRDRDH 733

Query: 402  SRSRSPNKARDRSRSRSPYKA-RDRSRSRSPNKARDCSRSRSPYKARDRSRSRS-----P 455
             R R   + RDR + R   +  R+R R R   + R+  R R   + RD+ R R       
Sbjct: 734  DRERERERERDREKEREREREERERERERERERERERERERERARERDKERERQRDWEDK 793

Query: 456  NKARDHSRS--------RSPNKARDRSRSR-------------SPSKERDHSQ-----LG 489
            +K RD  R         R+P    D  +S+             SP + R+HS        
Sbjct: 794  DKGRDDRREKREEIREDRNPRDGHDERKSKKRYRNEGSPSPRQSPKRRREHSPDSDAYNS 853

Query: 490  SPSKERDHR-----------RSRSPSKERQCRQSRSSSKERDHRRSRSP----------- 527
               K   HR           RS SPS   + RQ R   ++R   R  S            
Sbjct: 854  GDDKNEKHRLLSQVVRPQESRSLSPSHLTEDRQGRWKEEDRKPERKESSRRYEEQELKEK 913

Query: 528  --SKERQRRQSRSPNKERDRSQSRSPSEEREHRQSRSPSKERDRRRWR------------ 573
              S ++QR Q+      R R+Q      + E R++   + + ++++ +            
Sbjct: 914  VSSVDKQREQTEILESSRMRAQDIIGHHQSEDRETSDRAHDENKKKAKIQKKPIKKKKED 973

Query: 574  -------------------SPSK-------ERERRQSRSSSEERDHSRSRSPNKQSGYSR 607
                               SP K       E++R++S+  S+  D   ++   K+ G   
Sbjct: 974  DVGIERGNIETTSEDGQVFSPKKGQKKKSIEKKRKKSKGDSDISDEEAAQQSKKKRGPRT 1033

Query: 608  PRASSKEKAHSRSRTPSKEGNHSQSRTSSKESDPSQSTVPRSPDWKRSPTRTSSLSQNRT 667
            P  ++KE+        +     SQ +  +  SD S   VP   +   +    ++ +   T
Sbjct: 1034 PPITTKEELVEMCNGKNGILEDSQKKEDTAFSDWSDEDVPDRTEVTEAEHTATATTPGST 1093

Query: 668  PSKTSSHSPSTFPSGGQTLSQDDSQADATTSKATLPGERSSSSSS 712
            PS  SS  P   P          + A ATT  ATL    +++++S
Sbjct: 1094 PSPLSSLLPPPPPV---------ATATATTVPATLAATTAAAATS 1129



 Score = 76.3 bits (186), Expect = 9e-14
 Identities = 159/685 (23%), Positives = 238/685 (34%), Gaps = 74/685 (10%)

Query: 53   RNSVMSPSSSKSTKSTSTKRAPSNRPSSRSRVRSKARTPSRVSTDTRTSKASKASDV-RC 111
            RN        KS K    + +PS R S + R      + +  S D +  K    S V R 
Sbjct: 811  RNPRDGHDERKSKKRYRNEGSPSPRQSPKRRREHSPDSDAYNSGDDKNEKHRLLSQVVRP 870

Query: 112  HQRRGTHSRGRTPGRRGS-RSSKRSPSRASTPGRIRTHGARPGMAS--RVRTPTSQQKGS 168
             + R       T  R+G  +   R P R  +  R      +  ++S  + R  T   + S
Sbjct: 871  QESRSLSPSHLTEDRQGRWKEEDRKPERKESSRRYEEQELKEKVSSVDKQREQTEILESS 930

Query: 169  RGKSY---GRPRTSNRERSDS-----------QPRNLSKKSYRPPG--GSGIGRSSELAV 212
            R ++    G  ++ +RE SD            Q + + KK     G     I  +SE   
Sbjct: 931  RMRAQDIIGHHQSEDRETSDRAHDENKKKAKIQKKPIKKKKEDDVGIERGNIETTSEDGQ 990

Query: 213  TPSTAKCQTPTGIPSKEK--------SDNPSPSSSRKVKSYGQMIIPSREKSYSPTEMSS 264
              S  K Q    I  K K        SD  +   S+K +      I ++E+        +
Sbjct: 991  VFSPKKGQKKKSIEKKRKKSKGDSDISDEEAAQQSKKKRGPRTPPITTKEELVEMCNGKN 1050

Query: 265  RVKSYNQASTRSRPQSHSQSRSPRRSRSGSQKRTHSRVRSHSWKRNHSR----------A 314
             +   +Q    +     S    P R+     + T +     S     S           A
Sbjct: 1051 GILEDSQKKEDTAFSDWSDEDVPDRTEVTEAEHTATATTPGSTPSPLSSLLPPPPPVATA 1110

Query: 315  RSRTRKGILSQMGRHSQSRSHSKGKSQNQSRTPRRGRSHNWSRNPSKERSHSHSRSSSKE 374
             + T    L+     + +   +   + + S TP    ++ ++   S  + H  +R    E
Sbjct: 1111 TATTVPATLAATTAAAATSFSTSAITISTSATPTNTTNNTFANEDSHRKCH-RTRVEKVE 1169

Query: 375  RDH-----RGSSSPRKESGRSQSGSPNKQRDHSRSRSPNKARDRS-RSRSPYKARDRSRS 428
              H          P  +   S  GS    R H+  R  + + D + RS      R R   
Sbjct: 1170 TPHVTIEDAQHRKPMDQKRSSSLGSNRSNRSHTSGRLRSPSNDSAHRSGDDQSGRKRVLH 1229

Query: 429  RSPNKARDCSRSRSPYKARDRSRSRSPNKARDHSRSRSPNKARDRSRSRSPSKERDHSQL 488
                 +RD  +++S     +R       K  + SRS S     DR  SRS S  R     
Sbjct: 1230 SG---SRDREKTKSLEITGERKSRIDQLKRGEPSRSTSS----DRQDSRSHSSRRS---- 1278

Query: 489  GSPSKERDHRRSRSPSKERQCRQSRSSSKERDHRRSRSPSKERQRRQSRSPNKERDRSQS 548
             SP  +R    SRS S + + R       E D  R R     RQR   R  +K+  R++ 
Sbjct: 1279 -SPESDRQVH-SRSGSFDSRDRLQERDRYEHDRERERERRDTRQREWDRDADKDWPRNRD 1336

Query: 549  RSPSEEREHRQSRSPSKERDRRRWRSPSKERERRQSRSSSEERDHSRSRSPNKQSGYSRP 608
            R    ERE        +ER+R + R   +ERER  S S   +RD  R R+       S  
Sbjct: 1337 RDRLRERE--------RERERDKRRDLDRERERLISDSVERDRDRDRDRTFESSQIESVK 1388

Query: 609  RASSK-EKAHSRSRTPSKEGNHSQSRTSSKE-SDPSQSTVPRSPDWKRSPTRTSSLSQNR 666
            R  +K E  H R      E     S    KE  D    +V    +  +S  RT SL    
Sbjct: 1389 RCEAKLEGEHER----DLESTSRDSLALDKERMDKDLGSVQGFEETNKS-ERTESLEAGD 1443

Query: 667  TPSK-TSSHSPSTFPSGGQTLSQDD 690
              SK   +HS  +    G     DD
Sbjct: 1444 DESKLDDAHSLGSGAGEGYEPISDD 1468



 Score = 62.8 bits (151), Expect = 1e-09
 Identities = 82/338 (24%), Positives = 135/338 (39%), Gaps = 30/338 (8%)

Query: 346 TPR-RGRSHNWSRNPSKERSHSHSRSSSKERDHRGSSSPRKESGRSQSGSPNKQRDHSRS 404
           +PR +G S N+ R+P +       R  +K +D    + P+K +    S    K+    R 
Sbjct: 64  SPRGKGYSSNYRRSPERPTGDLRERMKNKRQDV--DTEPQKRNTEESSSPVRKESSRGRH 121

Query: 405 RSPNKARDRSRSRSPYKARDRSRSRSPNKARDCSRSRSPYKARDRSRSRSPNKARDHSRS 464
           R     +  ++ R+P    +     +     D       Y        +     R+  + 
Sbjct: 122 REKEDIK-ITKERTPESEEENVEWETNRDDSDNGDINYDYVHELSLEMKRQKIQRELMKL 180

Query: 465 RSPN--KARDRSRSRSPSKERDHSQLGSPSKERDHRRSRSPSKERQCRQSRSSSKERDHR 522
              N  K  +    +  S E   S+L SPS     + S+SP ++   + S +S K+R   
Sbjct: 181 EQENMEKREEIIIKKEVSPEVVRSKL-SPSPSL-RKSSKSPKRKSSPKSSSASKKDRKTS 238

Query: 523 RSRSPSKERQRRQSRSPNKER-DRSQSRSPS-----------EEREHRQSRSPSKERD-R 569
              SP  ++QR    + +K++  R+ S  P            +E+   + R   K RD +
Sbjct: 239 AVSSPLLDQQRNSKTNQSKKKGPRTPSPPPPIPEDIALGKKYKEKYKVKDRIEEKTRDGK 298

Query: 570 RRWRSPSKERERR-QSRSSSEERDH-----SRSRSPNKQSGYSRPRASSKEKAHSRSRTP 623
            R R   ++RE+R + RS+S    H     SR  S + QSG S  R S   +   R RTP
Sbjct: 299 DRGRDFERQREKRDKPRSTSPAGQHHSPISSRHHSSSSQSGSSIQRHSPSPR---RKRTP 355

Query: 624 SKEGNHSQSRTSSKESDPSQSTVPRSPDWKRSPTRTSS 661
           S     + +    + + P  S    SP  K+SP R  S
Sbjct: 356 SPSYQRTLTPPLRRSASPYPSHSLSSPQRKQSPPRHRS 393



 Score = 47.0 bits (110), Expect = 6e-05
 Identities = 79/379 (20%), Positives = 129/379 (34%), Gaps = 63/379 (16%)

Query: 7    SSKPSMSLAPSGSSMPTADPKPPASLKSTKSATPNRSLVPTKPATSRNSVMSPSSSKSTK 66
            ++ P  + +P  S +P   P PP +  +  +     +      ATS ++     S+ +T 
Sbjct: 1087 ATTPGSTPSPLSSLLP---PPPPVATATATTVPATLAATTAAAATSFSTSAITISTSATP 1143

Query: 67   STSTKRAPSNRPSSRSRVRS---KARTPSRVSTDTRTSKASKASDVRCHQRRGTHSRGRT 123
            + +T    +N  S R   R+   K  TP     D +                  H +   
Sbjct: 1144 TNTTNNTFANEDSHRKCHRTRVEKVETPHVTIEDAQ------------------HRKPMD 1185

Query: 124  PGRRGSRSSKRSPSRASTPGRIRTHGARPGMASRVRTPTSQQKGSRGKSYGRPRTSNRER 183
              R  S  S RS +R+ T GR+R+    P   S  R+   Q         GR R  +   
Sbjct: 1186 QKRSSSLGSNRS-NRSHTSGRLRS----PSNDSAHRSGDDQS--------GRKRVLH--- 1229

Query: 184  SDSQPRNLSKKSYRPPGGSGIGRSSELAVTPSTAKCQTPTGIPSKEKSDNPSPSSSRKVK 243
            S S+ R  +K             S E+     +   Q   G PS+  S +   S S   +
Sbjct: 1230 SGSRDREKTK-------------SLEITGERKSRIDQLKRGEPSRSTSSDRQDSRSHSSR 1276

Query: 244  SYGQMIIPSREKSYSPTEMSSRVKSYNQASTRSRPQSHSQSRSPRRSRSGSQKRTHSRVR 303
                     R    S  ++ SR  S++          +   R   R R  +++R   R  
Sbjct: 1277 ---------RSSPESDRQVHSRSGSFDSRDRLQERDRYEHDRERERERRDTRQREWDRDA 1327

Query: 304  SHSWKRNHSRARSRTRKGILSQMGRHSQSRSHSKGKSQNQSRTPRRGRSHNWSRNPSKER 363
               W RN  R R R R+    +  R    R   +  S +  R   R R   +  +  +  
Sbjct: 1328 DKDWPRNRDRDRLRERERERERDKRRDLDRERERLISDSVERDRDRDRDRTFESSQIESV 1387

Query: 364  SHSHSR-SSSKERDHRGSS 381
                ++     ERD   +S
Sbjct: 1388 KRCEAKLEGEHERDLESTS 1406


>gi|116089325 splicing factor, arginine/serine-rich 12 isoform a
           [Homo sapiens]
          Length = 624

 Score =  151 bits (381), Expect = 2e-36
 Identities = 111/364 (30%), Positives = 176/364 (48%), Gaps = 44/364 (12%)

Query: 315 RSRTRKGILSQMGRHSQSRSHSKGKSQNQSRTPRRGRSHNWSRNPSKERSHSHSRSSSKE 374
           +S  RKG         +SRSH++ KS++ S++  R +     R+ SK RS SH+RS S++
Sbjct: 299 KSNERKG--------GRSRSHTRSKSRSSSKSHSRRK-----RSQSKHRSRSHNRSRSRQ 345

Query: 375 RDHRGSSSPRKESGRSQSGSPNKQRDHSRSRSPNKARDRSRSRSPYKARDRSRSRSPNKA 434
           +D R S SP K+  +S+    ++ R HSR +  +  R++ + +   K +DR + R   K 
Sbjct: 346 KDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKD-TREKIKEKERVKEKDREKEREREKE 404

Query: 435 RDCSRSRSPYKARDRSRSRSPNKARDHSRSRSPNKARDRSRSRSPSKERDHSQLGSPSKE 494
           R+  + R   K RD+ R +   K ++  R R   K  ++ R +   KE+D        KE
Sbjct: 405 REKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKE------KE 458

Query: 495 RDHRRSRSPSKERQCRQSRSSSKERDH---RRSRSPSKERQRRQSRSPNKERDRSQSRSP 551
           R+  RS+   ++R+ +  +S +  R +   RRSRS S+ER+RR        R RS SRSP
Sbjct: 459 REKDRSKEIDEKRK-KDKKSRTPPRSYNASRRSRSSSRERRRR--------RSRSSSRSP 509

Query: 552 --SEEREHRQSRSPSKERDRRRWRSPSKERERRQSRSSSEERDHSRSRSPNKQSGYSRPR 609
             S+  + + SRSPS     ++ +   KER+       SE R+  RS S  K S      
Sbjct: 510 RTSKTIKRKSSRSPSPRSRNKKDKKREKERDH-----ISERRERERSTSMRKSSN----D 560

Query: 610 ASSKEKAHSRSRTPSKEGNHSQSRTSSKESDPSQSTVPRSPDWKRSPTRTSSLSQNRTPS 669
              KEK    S T  KE  H++   SS   +      PR+ + K        L++    +
Sbjct: 561 RDGKEKLEKNS-TSLKEKEHNKEPDSSVSKEVDDKDAPRTEENKIQHNGNCQLNEENLST 619

Query: 670 KTSS 673
           KT +
Sbjct: 620 KTEA 623



 Score =  134 bits (338), Expect = 2e-31
 Identities = 107/357 (29%), Positives = 164/357 (45%), Gaps = 25/357 (7%)

Query: 354 NWSRNPSKERSHSHSRSSSKERDHRGSSSPRKESGRSQSGSPNKQRDHSRSRSPNKARDR 413
           N S N   +      ++++KE +         +S  S +  P   + + R    +++  R
Sbjct: 254 NHSNNAIVKPPEMTPQAAAKELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTR 313

Query: 414 SRSRSPYKARDRSRSRSPNKARDCSRSRSPYKARDRSRSRSPNKARDHSRSRSPNKARDR 473
           S+SRS  K+  R R RS +K R  S +RS  + +DR RS+SP+K R  S+SR   K+R R
Sbjct: 314 SKSRSSSKSHSR-RKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKR--SKSRERRKSRSR 370

Query: 474 SRSRSPSKE-RDHSQLGSPSKERDHRRSRSPSKERQCRQSRSSSKERDHRR--SRSPSKE 530
           S SR   K+ R+  +     KE+D  + R   KER+  + R  +K+RD  R   R   KE
Sbjct: 371 SHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDKE 430

Query: 531 RQRRQSRSPNKERDRSQSRSPSEEREHRQSRSPSKERDRRRWRS------PSKERERRQS 584
           + R + R    E+DR + +   +++E  + +  SKE D +R +       P      R+S
Sbjct: 431 KDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRS 490

Query: 585 RSSSEERDHSRSRSPNKQSGYSRPRASSKEKAHSRSRTPSKEGNHSQSRTSSKESD--PS 642
           RSSS ER   RSRS ++      PR S   K  S SR+PS    + + +   KE D    
Sbjct: 491 RSSSRERRRRRSRSSSRS-----PRTSKTIKRKS-SRSPSPRSRNKKDKKREKERDHISE 544

Query: 643 QSTVPRSPDWKRSPT---RTSSLSQNRTPSKTSSHSPSTFPSGGQTLSQDDSQADAT 696
           +    RS   ++S         L +N T  K   H+    P    +   DD  A  T
Sbjct: 545 RRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKE--PDSSVSKEVDDKDAPRT 599



 Score =  132 bits (332), Expect = 1e-30
 Identities = 97/336 (28%), Positives = 174/336 (51%), Gaps = 38/336 (11%)

Query: 380 SSSPRKESGRSQSGSPNKQRDHSRSRSPNKARDRSRSRSPYKARDRSRSRSPNKARDCSR 439
           S++   ESG+S      + R H+RS+S + ++  SR         R RS+S +++R  +R
Sbjct: 290 SAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSR---------RKRSQSKHRSRSHNR 340

Query: 440 SRSPYKARDRSRSRSPNKARDHSRSRSPNKARDRSRSRSPSKERDHSQLGSPSKERDHRR 499
           SRS  + +DR RS+SP+K R  SR R     + RSRS S  K +D       ++E+   +
Sbjct: 341 SRS--RQKDRRRSKSPHKKRSKSRERR----KSRSRSHSRDKRKD-------TREKIKEK 387

Query: 500 SRSPSKERQCRQSRSSSKERDHRRSRSPSKERQRRQSRSPNKERDRSQSRSPSEEREHRQ 559
            R   K+R+  + R   +E++  R ++  ++++R + R  +KE+DR + R    E+EH +
Sbjct: 388 ERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDRERER----EKEHEK 443

Query: 560 SRSPSKERDRRRWRSPSKERERRQSRSSSEER-DHSRSRSPNKQSGYS-RPRASSKEKAH 617
            R   KE+++ +     KERE+ +S+   E+R    +SR+P +    S R R+SS+E+  
Sbjct: 444 DRDKEKEKEQDK----EKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRR 499

Query: 618 SRSRTPSKEGNHSQSRTSSKESDPSQSTVPRSPDWKRSPTRTSSLSQNRTPSKTSSHSPS 677
            RSR+ S+  +   S+T  ++S  S S   R+   K+       +S+ R   +++S   S
Sbjct: 500 RRSRSSSR--SPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTSMRKS 557

Query: 678 TFPSGGQTLSQDDSQADATTSKATLPGERSSSSSSK 713
           +    G    ++  + ++T+ K     +   SS SK
Sbjct: 558 SNDRDG----KEKLEKNSTSLKEKEHNKEPDSSVSK 589



 Score =  127 bits (320), Expect = 3e-29
 Identities = 93/316 (29%), Positives = 150/316 (47%), Gaps = 30/316 (9%)

Query: 291 RSGSQKRTHSRVRSHSWKRNHSRARSRTRKGILSQMGRHSQSRSHSKGKSQNQSRTPRRG 350
           R G + R+H+R +S S  ++HSR     RK   S+    S +RS S+ K + +S++P + 
Sbjct: 303 RKGGRSRSHTRSKSRSSSKSHSR-----RKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKK 357

Query: 351 RSHNWSRNPSKERSHSHSRSSSKERDHRGSSSPR-KESGRSQSGSPNKQRDHSRSRSPNK 409
           RS   SR   K RS SHSR   K+   +     R KE  R +     K+R+  + R  NK
Sbjct: 358 RSK--SRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNK 415

Query: 410 ARDRSRSRSPYKARDRSRSRSPNKARDCSRSRSPYKARDRSRSRSPNKARD-------HS 462
            RD+ R +   K +++ R R   K  +  R +   K +D+ + R  +++++         
Sbjct: 416 DRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDK 475

Query: 463 RSRSPNKA-----RDRSRSRSPSKERDHSQLGSP--SKERDHRRSRSPSKERQCRQSRSS 515
           +SR+P ++     R RS SR   + R  S   SP  SK    + SRSPS   + ++ +  
Sbjct: 476 KSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKR 535

Query: 516 SKERDHRRSRSPSKERQRRQSRSPNKERDRSQSRSPSEEREHRQSRSPSKERDRRRWRSP 575
            KERDH      S+ R+R +S S  K    S  R   E+ E   +    KE ++    S 
Sbjct: 536 EKERDH-----ISERRERERSTSMRKS---SNDRDGKEKLEKNSTSLKEKEHNKEPDSSV 587

Query: 576 SKERERRQSRSSSEER 591
           SKE + + +  + E +
Sbjct: 588 SKEVDDKDAPRTEENK 603



 Score =  116 bits (290), Expect = 8e-26
 Identities = 92/325 (28%), Positives = 155/325 (47%), Gaps = 26/325 (8%)

Query: 254 EKSYSPTEMSSRVKSYNQASTRSRPQSHSQSRSPRRSRSGSQKRTHSRVRSHSWKRNHSR 313
           E   S      R +S+ ++ +RS  +SHS     RR RS S+ R+ S  RS S +++  R
Sbjct: 296 ESGKSNERKGGRSRSHTRSKSRSSSKSHS-----RRKRSQSKHRSRSHNRSRSRQKDRRR 350

Query: 314 ARSRTRKGILSQMGRHSQSRSHSKGKSQNQSRTPRRGRSHNWSRNPSKERSHSHSRSSSK 373
           ++S  +K   S+  R S+SRSHS+ K ++ +R   + +     ++  KER     R   K
Sbjct: 351 SKSPHKKRSKSRERRKSRSRSHSRDKRKD-TREKIKEKERVKEKDREKEREREKEREKEK 409

Query: 374 ERDHRGSSSPRKESGRSQSGSPNKQRDHSRSRSPNKARDRSRSRSPYKARDRSRSRS-PN 432
           ER         +E  R +    +++R+  +    ++ +++ + +   K R++ RS+    
Sbjct: 410 ERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDE 469

Query: 433 KARDCSRSRSPYKA-----RDRSRSRSPNKARDHSRSRSP--NKARDRSRSRSPSKERDH 485
           K +   +SR+P ++     R RS SR   + R  S SRSP  +K   R  SRSPS    +
Sbjct: 470 KRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRN 529

Query: 486 SQLGSPSKERDHRRSRSPSKERQCRQS-RSSSKERDHRRSRSPSKERQRRQSRSPNKERD 544
            +     KERDH   R   +ER+   S R SS +RD        KE+  + S S  KE++
Sbjct: 530 KKDKKREKERDHISER---RERERSTSMRKSSNDRD-------GKEKLEKNSTS-LKEKE 578

Query: 545 RSQSRSPSEEREHRQSRSPSKERDR 569
            ++    S  +E     +P  E ++
Sbjct: 579 HNKEPDSSVSKEVDDKDAPRTEENK 603



 Score = 72.8 bits (177), Expect = 1e-12
 Identities = 82/369 (22%), Positives = 143/369 (38%), Gaps = 62/369 (16%)

Query: 121 GRTPGRRGSRSSKRSPSRASTPGRIRTHGARPGMASRVRTPTSQQKGSRGKSYGRPRTSN 180
           G++  R+G RS  RS +R+ +    ++H  R    S+ R+ +  +  SR K   R ++ +
Sbjct: 298 GKSNERKGGRS--RSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPH 355

Query: 181 RERSDSQPRNLSKKSYRPPGGSGIGRSSELAVTPSTAKCQTPTGIPSKEKSDNPSPSSSR 240
           ++RS S+ R  S+                                 S+  S +    +  
Sbjct: 356 KKRSKSRERRKSR---------------------------------SRSHSRDKRKDTRE 382

Query: 241 KVKSYGQMIIPSREKSYSPTEMSSRVKSYNQASTRSRPQSHSQSRSPRRSRSGSQKRTHS 300
           K+K   ++    REK         R K   +   R + +   + R   R +   + R   
Sbjct: 383 KIKEKERVKEKDREKE------REREKEREKEKERGKNKDRDKEREKDREKDKEKDRERE 436

Query: 301 RVRSHSWKRNHSRARSRTRKGILSQMGRHSQSRSHSKGKSQNQSRTPRRGRSHNWSRNPS 360
           R + H   R+  + + + ++    +  +        K K   +SRTP R  S+N SR   
Sbjct: 437 REKEHEKDRDKEKEKEQDKE---KEREKDRSKEIDEKRKKDKKSRTPPR--SYNASR--- 488

Query: 361 KERSHSHSRSSSKERDHRGSSSPR--KESGRSQSGSPNKQRDHSRSRSPNKARDRSRSRS 418
             RS S SR   + R    S SPR  K   R  S SP+ +  + + +   K RD    R 
Sbjct: 489 --RSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISER- 545

Query: 419 PYKARDRSRSRSPNKARDCSRSRSPYKARDRS-RSRSPNKARDHSRSRSPNKARDRSRSR 477
               R+R RS S  K+ +    +   +    S + +  NK  D S S+   +  D+   R
Sbjct: 546 ----RERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSK---EVDDKDAPR 598

Query: 478 SPSKERDHS 486
           +   +  H+
Sbjct: 599 TEENKIQHN 607



 Score = 72.0 bits (175), Expect = 2e-12
 Identities = 86/354 (24%), Positives = 139/354 (39%), Gaps = 20/354 (5%)

Query: 44  LVPTKPATSRNSVMSPSSSKSTKSTSTKRAPSNRPSSRS--RVRSKARTPSRVSTDTRTS 101
           + P   A     VM       +  ++     S + + R   R RS  R+ SR S+ + + 
Sbjct: 266 MTPQAAAKELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSR 325

Query: 102 KASKASDVRCHQRRGTHSRGRTPGRRGSRS--SKRSPSRASTPGRIRTHGARPGMASRVR 159
           +  K S  +   R    SR R   RR S+S   KRS SR     R R+H       +R +
Sbjct: 326 R--KRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREK 383

Query: 160 TPTSQQKGSRGKSYGRPRTSNRERSDSQPRNLSKKSYRPPGGSGIGRSSELAVTPSTAKC 219
               ++   + +   R R   RE+   + +N  +   R        R  +        + 
Sbjct: 384 IKEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREK-----DREKDKEKDRERERE 438

Query: 220 QTPTGIPSKEKSDNPSPSSSRKVKSYGQMIIPSREKSYSPTEMSSRVKSYNQASTRSRPQ 279
           +       KEK         R+ K   + I   R+K     +  +  +SYN AS RSR  
Sbjct: 439 KEHEKDRDKEKEKEQDKEKERE-KDRSKEIDEKRKKD---KKSRTPPRSYN-ASRRSR-- 491

Query: 280 SHSQSRSPRRSRSGSQK-RTHSRVRSHSWKRNHSRARSRTRKGILSQMGRHSQSRSHSKG 338
           S S+ R  RRSRS S+  RT   ++  S +    R+R++  K    +    S+ R   + 
Sbjct: 492 SSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERS 551

Query: 339 KSQNQSRTPRRGRSHNWSRNPS-KERSHSHSRSSSKERDHRGSSSPRKESGRSQ 391
            S  +S   R G+      + S KE+ H+    SS  ++     +PR E  + Q
Sbjct: 552 TSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDKDAPRTEENKIQ 605


>gi|21040255 splicing factor, arginine/serine-rich 12 isoform b
           [Homo sapiens]
          Length = 508

 Score =  151 bits (381), Expect = 2e-36
 Identities = 111/364 (30%), Positives = 176/364 (48%), Gaps = 44/364 (12%)

Query: 315 RSRTRKGILSQMGRHSQSRSHSKGKSQNQSRTPRRGRSHNWSRNPSKERSHSHSRSSSKE 374
           +S  RKG         +SRSH++ KS++ S++  R +     R+ SK RS SH+RS S++
Sbjct: 183 KSNERKG--------GRSRSHTRSKSRSSSKSHSRRK-----RSQSKHRSRSHNRSRSRQ 229

Query: 375 RDHRGSSSPRKESGRSQSGSPNKQRDHSRSRSPNKARDRSRSRSPYKARDRSRSRSPNKA 434
           +D R S SP K+  +S+    ++ R HSR +  +  R++ + +   K +DR + R   K 
Sbjct: 230 KDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKD-TREKIKEKERVKEKDREKEREREKE 288

Query: 435 RDCSRSRSPYKARDRSRSRSPNKARDHSRSRSPNKARDRSRSRSPSKERDHSQLGSPSKE 494
           R+  + R   K RD+ R +   K ++  R R   K  ++ R +   KE+D        KE
Sbjct: 289 REKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKE------KE 342

Query: 495 RDHRRSRSPSKERQCRQSRSSSKERDH---RRSRSPSKERQRRQSRSPNKERDRSQSRSP 551
           R+  RS+   ++R+ +  +S +  R +   RRSRS S+ER+RR        R RS SRSP
Sbjct: 343 REKDRSKEIDEKRK-KDKKSRTPPRSYNASRRSRSSSRERRRR--------RSRSSSRSP 393

Query: 552 --SEEREHRQSRSPSKERDRRRWRSPSKERERRQSRSSSEERDHSRSRSPNKQSGYSRPR 609
             S+  + + SRSPS     ++ +   KER+       SE R+  RS S  K S      
Sbjct: 394 RTSKTIKRKSSRSPSPRSRNKKDKKREKERDH-----ISERRERERSTSMRKSSN----D 444

Query: 610 ASSKEKAHSRSRTPSKEGNHSQSRTSSKESDPSQSTVPRSPDWKRSPTRTSSLSQNRTPS 669
              KEK    S T  KE  H++   SS   +      PR+ + K        L++    +
Sbjct: 445 RDGKEKLEKNS-TSLKEKEHNKEPDSSVSKEVDDKDAPRTEENKIQHNGNCQLNEENLST 503

Query: 670 KTSS 673
           KT +
Sbjct: 504 KTEA 507



 Score =  134 bits (338), Expect = 2e-31
 Identities = 107/357 (29%), Positives = 164/357 (45%), Gaps = 25/357 (7%)

Query: 354 NWSRNPSKERSHSHSRSSSKERDHRGSSSPRKESGRSQSGSPNKQRDHSRSRSPNKARDR 413
           N S N   +      ++++KE +         +S  S +  P   + + R    +++  R
Sbjct: 138 NHSNNAIVKPPEMTPQAAAKELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTR 197

Query: 414 SRSRSPYKARDRSRSRSPNKARDCSRSRSPYKARDRSRSRSPNKARDHSRSRSPNKARDR 473
           S+SRS  K+  R R RS +K R  S +RS  + +DR RS+SP+K R  S+SR   K+R R
Sbjct: 198 SKSRSSSKSHSR-RKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKR--SKSRERRKSRSR 254

Query: 474 SRSRSPSKE-RDHSQLGSPSKERDHRRSRSPSKERQCRQSRSSSKERDHRR--SRSPSKE 530
           S SR   K+ R+  +     KE+D  + R   KER+  + R  +K+RD  R   R   KE
Sbjct: 255 SHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDKE 314

Query: 531 RQRRQSRSPNKERDRSQSRSPSEEREHRQSRSPSKERDRRRWRS------PSKERERRQS 584
           + R + R    E+DR + +   +++E  + +  SKE D +R +       P      R+S
Sbjct: 315 KDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRS 374

Query: 585 RSSSEERDHSRSRSPNKQSGYSRPRASSKEKAHSRSRTPSKEGNHSQSRTSSKESD--PS 642
           RSSS ER   RSRS ++      PR S   K  S SR+PS    + + +   KE D    
Sbjct: 375 RSSSRERRRRRSRSSSRS-----PRTSKTIKRKS-SRSPSPRSRNKKDKKREKERDHISE 428

Query: 643 QSTVPRSPDWKRSPT---RTSSLSQNRTPSKTSSHSPSTFPSGGQTLSQDDSQADAT 696
           +    RS   ++S         L +N T  K   H+    P    +   DD  A  T
Sbjct: 429 RRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKE--PDSSVSKEVDDKDAPRT 483



 Score =  132 bits (332), Expect = 1e-30
 Identities = 97/336 (28%), Positives = 174/336 (51%), Gaps = 38/336 (11%)

Query: 380 SSSPRKESGRSQSGSPNKQRDHSRSRSPNKARDRSRSRSPYKARDRSRSRSPNKARDCSR 439
           S++   ESG+S      + R H+RS+S + ++  SR         R RS+S +++R  +R
Sbjct: 174 SAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSR---------RKRSQSKHRSRSHNR 224

Query: 440 SRSPYKARDRSRSRSPNKARDHSRSRSPNKARDRSRSRSPSKERDHSQLGSPSKERDHRR 499
           SRS  + +DR RS+SP+K R  SR R     + RSRS S  K +D       ++E+   +
Sbjct: 225 SRS--RQKDRRRSKSPHKKRSKSRERR----KSRSRSHSRDKRKD-------TREKIKEK 271

Query: 500 SRSPSKERQCRQSRSSSKERDHRRSRSPSKERQRRQSRSPNKERDRSQSRSPSEEREHRQ 559
            R   K+R+  + R   +E++  R ++  ++++R + R  +KE+DR + R    E+EH +
Sbjct: 272 ERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDRERER----EKEHEK 327

Query: 560 SRSPSKERDRRRWRSPSKERERRQSRSSSEER-DHSRSRSPNKQSGYS-RPRASSKEKAH 617
            R   KE+++ +     KERE+ +S+   E+R    +SR+P +    S R R+SS+E+  
Sbjct: 328 DRDKEKEKEQDK----EKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRR 383

Query: 618 SRSRTPSKEGNHSQSRTSSKESDPSQSTVPRSPDWKRSPTRTSSLSQNRTPSKTSSHSPS 677
            RSR+ S+  +   S+T  ++S  S S   R+   K+       +S+ R   +++S   S
Sbjct: 384 RRSRSSSR--SPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTSMRKS 441

Query: 678 TFPSGGQTLSQDDSQADATTSKATLPGERSSSSSSK 713
           +    G    ++  + ++T+ K     +   SS SK
Sbjct: 442 SNDRDG----KEKLEKNSTSLKEKEHNKEPDSSVSK 473



 Score =  127 bits (320), Expect = 3e-29
 Identities = 93/316 (29%), Positives = 150/316 (47%), Gaps = 30/316 (9%)

Query: 291 RSGSQKRTHSRVRSHSWKRNHSRARSRTRKGILSQMGRHSQSRSHSKGKSQNQSRTPRRG 350
           R G + R+H+R +S S  ++HSR     RK   S+    S +RS S+ K + +S++P + 
Sbjct: 187 RKGGRSRSHTRSKSRSSSKSHSR-----RKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKK 241

Query: 351 RSHNWSRNPSKERSHSHSRSSSKERDHRGSSSPR-KESGRSQSGSPNKQRDHSRSRSPNK 409
           RS   SR   K RS SHSR   K+   +     R KE  R +     K+R+  + R  NK
Sbjct: 242 RSK--SRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNK 299

Query: 410 ARDRSRSRSPYKARDRSRSRSPNKARDCSRSRSPYKARDRSRSRSPNKARD-------HS 462
            RD+ R +   K +++ R R   K  +  R +   K +D+ + R  +++++         
Sbjct: 300 DRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDK 359

Query: 463 RSRSPNKA-----RDRSRSRSPSKERDHSQLGSP--SKERDHRRSRSPSKERQCRQSRSS 515
           +SR+P ++     R RS SR   + R  S   SP  SK    + SRSPS   + ++ +  
Sbjct: 360 KSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKR 419

Query: 516 SKERDHRRSRSPSKERQRRQSRSPNKERDRSQSRSPSEEREHRQSRSPSKERDRRRWRSP 575
            KERDH      S+ R+R +S S  K    S  R   E+ E   +    KE ++    S 
Sbjct: 420 EKERDH-----ISERRERERSTSMRKS---SNDRDGKEKLEKNSTSLKEKEHNKEPDSSV 471

Query: 576 SKERERRQSRSSSEER 591
           SKE + + +  + E +
Sbjct: 472 SKEVDDKDAPRTEENK 487



 Score =  116 bits (290), Expect = 8e-26
 Identities = 92/325 (28%), Positives = 155/325 (47%), Gaps = 26/325 (8%)

Query: 254 EKSYSPTEMSSRVKSYNQASTRSRPQSHSQSRSPRRSRSGSQKRTHSRVRSHSWKRNHSR 313
           E   S      R +S+ ++ +RS  +SHS     RR RS S+ R+ S  RS S +++  R
Sbjct: 180 ESGKSNERKGGRSRSHTRSKSRSSSKSHS-----RRKRSQSKHRSRSHNRSRSRQKDRRR 234

Query: 314 ARSRTRKGILSQMGRHSQSRSHSKGKSQNQSRTPRRGRSHNWSRNPSKERSHSHSRSSSK 373
           ++S  +K   S+  R S+SRSHS+ K ++ +R   + +     ++  KER     R   K
Sbjct: 235 SKSPHKKRSKSRERRKSRSRSHSRDKRKD-TREKIKEKERVKEKDREKEREREKEREKEK 293

Query: 374 ERDHRGSSSPRKESGRSQSGSPNKQRDHSRSRSPNKARDRSRSRSPYKARDRSRSRS-PN 432
           ER         +E  R +    +++R+  +    ++ +++ + +   K R++ RS+    
Sbjct: 294 ERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDE 353

Query: 433 KARDCSRSRSPYKA-----RDRSRSRSPNKARDHSRSRSP--NKARDRSRSRSPSKERDH 485
           K +   +SR+P ++     R RS SR   + R  S SRSP  +K   R  SRSPS    +
Sbjct: 354 KRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRN 413

Query: 486 SQLGSPSKERDHRRSRSPSKERQCRQS-RSSSKERDHRRSRSPSKERQRRQSRSPNKERD 544
            +     KERDH   R   +ER+   S R SS +RD        KE+  + S S  KE++
Sbjct: 414 KKDKKREKERDHISER---RERERSTSMRKSSNDRD-------GKEKLEKNSTS-LKEKE 462

Query: 545 RSQSRSPSEEREHRQSRSPSKERDR 569
            ++    S  +E     +P  E ++
Sbjct: 463 HNKEPDSSVSKEVDDKDAPRTEENK 487



 Score = 72.8 bits (177), Expect = 1e-12
 Identities = 82/369 (22%), Positives = 143/369 (38%), Gaps = 62/369 (16%)

Query: 121 GRTPGRRGSRSSKRSPSRASTPGRIRTHGARPGMASRVRTPTSQQKGSRGKSYGRPRTSN 180
           G++  R+G RS  RS +R+ +    ++H  R    S+ R+ +  +  SR K   R ++ +
Sbjct: 182 GKSNERKGGRS--RSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPH 239

Query: 181 RERSDSQPRNLSKKSYRPPGGSGIGRSSELAVTPSTAKCQTPTGIPSKEKSDNPSPSSSR 240
           ++RS S+ R  S+                                 S+  S +    +  
Sbjct: 240 KKRSKSRERRKSR---------------------------------SRSHSRDKRKDTRE 266

Query: 241 KVKSYGQMIIPSREKSYSPTEMSSRVKSYNQASTRSRPQSHSQSRSPRRSRSGSQKRTHS 300
           K+K   ++    REK         R K   +   R + +   + R   R +   + R   
Sbjct: 267 KIKEKERVKEKDREKE------REREKEREKEKERGKNKDRDKEREKDREKDKEKDRERE 320

Query: 301 RVRSHSWKRNHSRARSRTRKGILSQMGRHSQSRSHSKGKSQNQSRTPRRGRSHNWSRNPS 360
           R + H   R+  + + + ++    +  +        K K   +SRTP R  S+N SR   
Sbjct: 321 REKEHEKDRDKEKEKEQDKE---KEREKDRSKEIDEKRKKDKKSRTPPR--SYNASR--- 372

Query: 361 KERSHSHSRSSSKERDHRGSSSPR--KESGRSQSGSPNKQRDHSRSRSPNKARDRSRSRS 418
             RS S SR   + R    S SPR  K   R  S SP+ +  + + +   K RD    R 
Sbjct: 373 --RSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISER- 429

Query: 419 PYKARDRSRSRSPNKARDCSRSRSPYKARDRS-RSRSPNKARDHSRSRSPNKARDRSRSR 477
               R+R RS S  K+ +    +   +    S + +  NK  D S S+   +  D+   R
Sbjct: 430 ----RERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSK---EVDDKDAPR 482

Query: 478 SPSKERDHS 486
           +   +  H+
Sbjct: 483 TEENKIQHN 491



 Score = 72.0 bits (175), Expect = 2e-12
 Identities = 86/354 (24%), Positives = 139/354 (39%), Gaps = 20/354 (5%)

Query: 44  LVPTKPATSRNSVMSPSSSKSTKSTSTKRAPSNRPSSRS--RVRSKARTPSRVSTDTRTS 101
           + P   A     VM       +  ++     S + + R   R RS  R+ SR S+ + + 
Sbjct: 150 MTPQAAAKELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSR 209

Query: 102 KASKASDVRCHQRRGTHSRGRTPGRRGSRS--SKRSPSRASTPGRIRTHGARPGMASRVR 159
           +  K S  +   R    SR R   RR S+S   KRS SR     R R+H       +R +
Sbjct: 210 R--KRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREK 267

Query: 160 TPTSQQKGSRGKSYGRPRTSNRERSDSQPRNLSKKSYRPPGGSGIGRSSELAVTPSTAKC 219
               ++   + +   R R   RE+   + +N  +   R        R  +        + 
Sbjct: 268 IKEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREK-----DREKDKEKDRERERE 322

Query: 220 QTPTGIPSKEKSDNPSPSSSRKVKSYGQMIIPSREKSYSPTEMSSRVKSYNQASTRSRPQ 279
           +       KEK         R+ K   + I   R+K     +  +  +SYN AS RSR  
Sbjct: 323 KEHEKDRDKEKEKEQDKEKERE-KDRSKEIDEKRKKD---KKSRTPPRSYN-ASRRSR-- 375

Query: 280 SHSQSRSPRRSRSGSQK-RTHSRVRSHSWKRNHSRARSRTRKGILSQMGRHSQSRSHSKG 338
           S S+ R  RRSRS S+  RT   ++  S +    R+R++  K    +    S+ R   + 
Sbjct: 376 SSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERS 435

Query: 339 KSQNQSRTPRRGRSHNWSRNPS-KERSHSHSRSSSKERDHRGSSSPRKESGRSQ 391
            S  +S   R G+      + S KE+ H+    SS  ++     +PR E  + Q
Sbjct: 436 TSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDKDAPRTEENKIQ 489


>gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo
           sapiens]
          Length = 600

 Score =  143 bits (360), Expect = 6e-34
 Identities = 109/439 (24%), Positives = 174/439 (39%), Gaps = 45/439 (10%)

Query: 253 REKSYSPTEMS-SRVKSYNQASTRSRPQSHSQSRSPRRSRSGSQKRTHSRVRSHSWKRNH 311
           REK  +  E    R +   +   R R +   + R   + R     R   R R     R  
Sbjct: 66  REKRQTERETDRKRERRREKDRHRKRDRHRERQRDREKERERQTDRERDRQREKERNRQK 125

Query: 312 SRARSRTRKGILSQMGRHSQS-----RSHSKGKSQNQSRTPRRGRSHNWSRNPSKERSHS 366
            R R   R+G   + GR  Q+     R   +   + + R   R R     RN  KER   
Sbjct: 126 ERERETEREG---ERGRDRQTDGQRERERQRDAEKERERQTDRERQRQTERNRQKERERE 182

Query: 367 HSRSSSKERDHRGSSSPRKESGRSQSGSPNKQRDHSRSRSPNKARDRSRSRSPYKARDRS 426
            +R   +ER+ +     + E   S+ G     R+  R R      +R R     + R R 
Sbjct: 183 KNRQERRERERQREKENKTEDRHSERG-----RERERERETETETERKRQTDRERDRQRK 237

Query: 427 RSRSPNKARDCSRSRSPYKARDRSRSRSPNKARDHS-RSRSPNKARDRSRSRSPSKERDH 485
             R   K  +  R+      RD+ R R  ++ RD   R +   +  DR R R   ++R+ 
Sbjct: 238 TEREREKQAERERASERETERDKERERERDRDRDRDRRQKERERQTDRKRQRRTERDRET 297

Query: 486 SQLGSPSKERDHRRSRSPSKERQCRQSRSSSKERDHRRSRSPSKERQRRQSRSPNKERDR 545
            +     +ER+  R R+  +ER+  + R   ++R+  R R   +ER+R++    ++ER+R
Sbjct: 298 ERKRERQRERERERERNRKRERERERERERERQRETERDREKERERKRKRQTEMDRERNR 357

Query: 546 SQSRSPSEEREH---------RQSRSPSKERDRRRWRSPSKERERR--QSRSSSEERDHS 594
              R    + E          RQS    +ER+R R R   KERER+  + R    E +  
Sbjct: 358 QTGREGRRQAERERERERERDRQSAREREERERDRDRDRQKERERQTEKDRDGQRETEKQ 417

Query: 595 RSRSPNKQSGYSRPRASSKEKAHSRSRTPSKEGNHSQSRTSSK----------------- 637
           R R  +++S   R R   +EK   R R   ++ +    R   +                 
Sbjct: 418 REREKDRESERGRERGREREKQKGRERDRERQTDRQAGRQRKRSTLYVNPPPRTARSGVV 477

Query: 638 ESDPSQSTVPRSPDWKRSP 656
           +SDP++ T  R   WK SP
Sbjct: 478 QSDPNRPT--RGIRWKSSP 494



 Score =  139 bits (351), Expect = 7e-33
 Identities = 98/403 (24%), Positives = 161/403 (39%), Gaps = 29/403 (7%)

Query: 274 TRSRPQSHSQSRSPRRSRSGSQKRTHSRVRSHSWKRNHSRARSRTRKGILSQMGRHSQSR 333
           +R RP S     SPRR   G   + H        +RN  + R R R+    +       R
Sbjct: 27  SRRRPGSQE---SPRRRGLG---QAHKDADGDDRERNRQKERERRRE---KRQTERETDR 77

Query: 334 SHSKGKSQNQSRTPRRGRSHNWSRNPSKERSHSHSRSSSKERDHRGSSSPRKESGRSQSG 393
              + + +++ R   R R     R   +ER     R   +E++        +E+ R    
Sbjct: 78  KRERRREKDRHRKRDRHRERQRDREKERERQTDRERDRQREKERNRQKERERETEREGER 137

Query: 394 SPNKQRDHSRSRSPNKARDRSRSRSPYKARDRSRSRSPNKARDCSRSRSPYKARDRSRSR 453
             ++Q D  R R   +  ++ R R   + R R   R+  K R+  ++R   + R+R R +
Sbjct: 138 GRDRQTDGQRERERQRDAEKERERQTDRERQRQTERNRQKEREREKNRQERRERERQREK 197

Query: 454 SPNKARDHSRSRSPNKARDRS------RSRSPSKERDHSQLGSPSKERDHRRSRSPSKER 507
             NK  D    R   + R+R       R R   +ERD  +     +ER+ +  R  + ER
Sbjct: 198 E-NKTEDRHSERGRERERERETETETERKRQTDRERDRQR--KTEREREKQAERERASER 254

Query: 508 QCRQSRSSSKERDHRRSRSPSKERQRRQSRSPNKERDRSQSRSPSEEREHRQSRSPSKER 567
           +  + +   +ERD  R R     RQ+ + R  +++R R   R    ER+  + R   +ER
Sbjct: 255 ETERDKERERERDRDRDRD---RRQKERERQTDRKRQRRTERDRETERKRERQRERERER 311

Query: 568 DRRRWRSPSKERERRQSRSSSEERDHSRSRSPNKQSGYSRPRASSKEKAHSRSRTPSKEG 627
           +R R R   +ERER + R    ERD  + R         R R    E    R+R   +EG
Sbjct: 312 ERNRKRERERERERERERQRETERDREKER--------ERKRKRQTEMDRERNRQTGREG 363

Query: 628 NHSQSRTSSKESDPSQSTVPRSPDWKRSPTRTSSLSQNRTPSK 670
                R   +E +  + +     + +R   R     + R   K
Sbjct: 364 RRQAERERERERERDRQSAREREERERDRDRDRQKERERQTEK 406



 Score =  138 bits (347), Expect = 2e-32
 Identities = 97/409 (23%), Positives = 156/409 (38%), Gaps = 18/409 (4%)

Query: 271 QASTRSRPQSHSQSRSPRRSRSGSQKRTHSRVRSHSWKRNHSRARSRTRKGILSQMGRHS 330
           Q     R +     R   R R   +++   R R    +R   R + R R+    +  +  
Sbjct: 59  QKERERRREKRQTERETDRKRERRREKDRHRKRDRHRERQRDREKERERQTDRERDRQRE 118

Query: 331 QSRSHSKGKSQNQSRTPRRGRSHNWSRNPSKERSHSHSRSSSKERDHRGSSSPRKESGRS 390
           + R+  K + +   R   RGR         +ER     +   ++ D        +   + 
Sbjct: 119 KERNRQKERERETEREGERGRDRQTDGQRERERQRDAEKERERQTDRERQRQTERNRQKE 178

Query: 391 QSGSPNKQRDHSRSR---SPNKARDRSRSRSPYKARDR------SRSRSPNKARDCSR-- 439
           +    N+Q    R R     NK  DR   R   + R+R       R R  ++ RD  R  
Sbjct: 179 REREKNRQERRERERQREKENKTEDRHSERGRERERERETETETERKRQTDRERDRQRKT 238

Query: 440 SRSPYKARDRSRSRSPNKARDHSRSRSPNKARDRSRSRSPSKERDHSQLGSPSKERDHRR 499
            R   K  +R R+      RD  R R  ++ RDR R R   +ER   +      ERD   
Sbjct: 239 EREREKQAERERASERETERDKERERERDRDRDRDR-RQKERERQTDRKRQRRTERDRET 297

Query: 500 SRSPSKERQCRQSRSSSKERDHRRSRSPSKERQRRQSRSPNKERDRSQSRSPSEEREHRQ 559
            R   ++R+  + R  +++R+  R R   +ERQR   R   KER+R + R    +RE  +
Sbjct: 298 ERKRERQRERERERERNRKRERERERERERERQRETERDREKERERKRKRQTEMDRERNR 357

Query: 560 SRSPSKERDRRRWRSPSKERERRQSRSSSE-ERDHSRSRSPNKQSGYSRPRASSKEKAHS 618
                  R   R R   +ER+R+ +R   E ERD  R R   ++    + R   +E    
Sbjct: 358 QTGREGRRQAERERERERERDRQSAREREERERDRDRDRQKERERQTEKDRDGQRETEKQ 417

Query: 619 RSRTPSKEGNHSQSRTSSKESDPSQSTVPRSPDWKRSPTRTSSLSQNRT 667
           R R   +E    + R   +E         R  D +R   R +   + R+
Sbjct: 418 REREKDRESERGRERGREREKQKG-----RERDRERQTDRQAGRQRKRS 461



 Score = 77.8 bits (190), Expect = 3e-14
 Identities = 52/215 (24%), Positives = 91/215 (42%), Gaps = 9/215 (4%)

Query: 472 DRSRSRSPSKERDHSQ-LGSPSKERD---HRRSRSPSKERQCRQSRSSSKERDHRRSRSP 527
           D SR R  S+E    + LG   K+ D     R+R   +ER+ R+ R + +E D +R R  
Sbjct: 25  DFSRRRPGSQESPRRRGLGQAHKDADGDDRERNRQKERERR-REKRQTERETDRKRERRR 83

Query: 528 SKERQRRQSRSPNKERDRSQSRSPSEEREH----RQSRSPSKERDRRRWRSPSKERERRQ 583
            K+R R++ R   ++RDR + R    +RE      + R+  KER+R   R   + R+R+ 
Sbjct: 84  EKDRHRKRDRHRERQRDREKERERQTDRERDRQREKERNRQKERERETEREGERGRDRQT 143

Query: 584 SRSSSEERDHSRSRSPNKQSGYSRPRASSKEKAHSRSRTPSKEGNHSQSRTSSKESDPSQ 643
                 ER     +   +Q+   R R + + +   R R  +++    + R   KE+    
Sbjct: 144 DGQRERERQRDAEKERERQTDRERQRQTERNRQKEREREKNRQERRERERQREKENKTED 203

Query: 644 STVPRSPDWKRSPTRTSSLSQNRTPSKTSSHSPST 678
               R  + +R     +   + R   +       T
Sbjct: 204 RHSERGRERERERETETETERKRQTDRERDRQRKT 238


>gi|166235169 PRP38 pre-mRNA processing factor 38 (yeast) domain
           containing B [Homo sapiens]
          Length = 546

 Score =  141 bits (356), Expect = 2e-33
 Identities = 102/314 (32%), Positives = 154/314 (49%), Gaps = 21/314 (6%)

Query: 328 RHSQSRSHSKGKSQNQSRTPRRGRSHNWSRNPSKERSHSHSRSSSKERDHRGSSS----- 382
           R  + +   K  ++   R   R RS +  R+ S  RS   SRS S  R+  GSSS     
Sbjct: 236 RPRKIKKDGKEGAEEIDRHVERRRSRSPRRSLSPRRSPRRSRSRSHHREGHGSSSFDREL 295

Query: 383 -PRKESGRSQSGSPNKQRDHSRSRSPNKARDRSRSRSPYKARDRSRSRS-PNKARDCSRS 440
              KE  R +  +  ++++  RSRS ++  +R RSRS  + R RSRSR      RD  R 
Sbjct: 296 EREKERQRLEREAKEREKERRRSRSIDRGLERRRSRSRERHRSRSRSRDRKGDRRDRDRE 355

Query: 441 RSPYKARDRSRSRSPNKARDHSRSRSPNKARDRS---RSRSPSKERDHSQLGSPSKERDH 497
           R     R R R R  +K R + R +   ++R+RS   RSR   +E+ H +     + RD 
Sbjct: 356 REKENERGRRRDRDYDKERGNEREKERERSRERSKEQRSRGEVEEKKHKEDKDDRRHRDD 415

Query: 498 RRSRSPSKERQCRQSRSSSKERDHR---RSRSPSKERQRRQSRSPNKERDRSQSRSPSEE 554
           +R     K    + SRS S+ER HR   RSR+  K  + R     +K ++ S+ +S    
Sbjct: 416 KRDSKKEK----KHSRSRSRERKHRSRSRSRNAGKRSRSRSKEKSSKHKNESKEKSNKRS 471

Query: 555 REHRQSRSPSKERDRRRWRSPSKERERRQSRSSSEERDHSRSRSPNKQSG--YSRPRASS 612
           R   Q R+ S E+ ++R  SPSKE+ R++SR  S+ER H R  S +K     + R R+ S
Sbjct: 472 RSGSQGRTDSVEKSKKREHSPSKEKSRKRSR--SKERSHKRDHSDSKDQSDKHDRRRSQS 529

Query: 613 KEKAHSRSRTPSKE 626
            E+     +  +K+
Sbjct: 530 IEQESQEKQHKNKD 543



 Score =  138 bits (347), Expect = 2e-32
 Identities = 110/323 (34%), Positives = 160/323 (49%), Gaps = 43/323 (13%)

Query: 275 RSRPQSHSQSRSPRRSRSGSQKRTHSRV--RSHSWKRNHSRARSRTRKGILSQMGRHSQS 332
           R R +S  +S SPRRS   S+ R+H R    S S+ R   R + R R      + R ++ 
Sbjct: 257 RRRSRSPRRSLSPRRSPRRSRSRSHHREGHGSSSFDRELEREKERQR------LEREAKE 310

Query: 333 RSHSKGKSQNQSRTPRRGRSHNWSRNPSKERSHSHSRSSSKERDHRGSSSPRK---ESGR 389
           R   + +S++  R   R RS       S+ER  S SRS  ++ D R     R+   E GR
Sbjct: 311 REKERRRSRSIDRGLERRRSR------SRERHRSRSRSRDRKGDRRDRDREREKENERGR 364

Query: 390 SQSGSPNKQRDHSRSRSPNKARDRS---RSRSPYKARDRSRSRSPNKARDCSRSRSPYKA 446
            +    +K+R + R +   ++R+RS   RSR   + +     +   + RD  R     K 
Sbjct: 365 RRDRDYDKERGNEREKERERSRERSKEQRSRGEVEEKKHKEDKDDRRHRDDKRDSKKEKK 424

Query: 447 RDRSRSRSPNKARDHSRSRSPNKARDRSRSRSPSKERDHSQLGSPSKERDHRRSRSPSKE 506
             RSRSR   K R  SRSR+  K   RSRSRS  K   H    + SKE+ ++RSRS S  
Sbjct: 425 HSRSRSRE-RKHRSRSRSRNAGK---RSRSRSKEKSSKHK---NESKEKSNKRSRSGS-- 475

Query: 507 RQCRQSRSSSKERDHRRSRSPSKERQRRQSRSPNKERDRSQSRSPSEEREHRQSRSPSKE 566
               Q R+ S E+  +R  SPSKE+ R++SRS  KER        S +R+H  S+  S +
Sbjct: 476 ----QGRTDSVEKSKKREHSPSKEKSRKRSRS--KER--------SHKRDHSDSKDQSDK 521

Query: 567 RDRRRWRSPSKERERRQSRSSSE 589
            DRRR +S  +E + +Q ++  E
Sbjct: 522 HDRRRSQSIEQESQEKQHKNKDE 544



 Score =  130 bits (328), Expect = 3e-30
 Identities = 98/317 (30%), Positives = 161/317 (50%), Gaps = 20/317 (6%)

Query: 373 KERDHRGSSSPRKESGRSQSGSPNKQRDHSRSRSPNKARDRSRSRSPYKARDRSRSRSPN 432
           K  D +  + PRK     + G+    R   R RS +  R  S  RSP ++R RS  R  +
Sbjct: 227 KNIDQQIKTRPRKIKKDGKEGAEEIDRHVERRRSRSPRRSLSPRRSPRRSRSRSHHREGH 286

Query: 433 KARDCSRSRSPYKARDRSRSRSPNKARDHSRSRSPNKARDRSRSRSPSKERDHSQLGSPS 492
            +    R     K R R    +  + ++  RSRS ++  +R RSRS  + R  S+    S
Sbjct: 287 GSSSFDRELEREKERQRLEREAKEREKERRRSRSIDRGLERRRSRSRERHRSRSR----S 342

Query: 493 KERDHRRSRSPSKERQCRQSRSSSKERDHRRSRSPSKERQRRQSRSPNKERDRSQSRSPS 552
           ++R   R R   +ER+    R   ++RD+ + R   +E++R +SR  +KE+   +SR   
Sbjct: 343 RDRKGDR-RDRDREREKENERGRRRDRDYDKERGNEREKERERSRERSKEQ---RSRGEV 398

Query: 553 EEREHRQSRSPSKERDRRRWRSPSKERERRQSRSSSEERDHSRSRSPNKQSGYSRPRASS 612
           EE++H++ +   + RD +R      ++E++ SRS S ER H RSRS ++ +G  R R+ S
Sbjct: 399 EEKKHKEDKDDRRHRDDKR----DSKKEKKHSRSRSRERKH-RSRSRSRNAG-KRSRSRS 452

Query: 613 KEKAHSRSRTPSKEGNHSQSRTSSKESDPSQSTVPRSPDWKRSPTRTSSLSQNRTPSKTS 672
           KEK+ S+ +  SKE ++ +SR+ S+    S   V +S   + SP++    S+ R+ SK  
Sbjct: 453 KEKS-SKHKNESKEKSNKRSRSGSQGRTDS---VEKSKKREHSPSKEK--SRKRSRSKER 506

Query: 673 SHSPSTFPSGGQTLSQD 689
           SH      S  Q+   D
Sbjct: 507 SHKRDHSDSKDQSDKHD 523



 Score =  124 bits (311), Expect = 3e-28
 Identities = 103/319 (32%), Positives = 148/319 (46%), Gaps = 40/319 (12%)

Query: 226 PSKEKSDNPSPSSSRKVKSYGQMIIPSREKSYSPTEMSSRVKSYNQASTRSRPQSHSQSR 285
           P +  S   SP  SR           SR         SS  +   +   R R +  ++ R
Sbjct: 263 PRRSLSPRRSPRRSR-----------SRSHHREGHGSSSFDRELEREKERQRLEREAKER 311

Query: 286 SPRRSRSGSQKRTHSRVRSHSWKRNHSRARSRTRKGILSQMGRHSQSRSHSKGKSQNQSR 345
              R RS S  R   R RS S +R+ SR+RSR RKG           R   + + +   R
Sbjct: 312 EKERRRSRSIDRGLERRRSRSRERHRSRSRSRDRKG---------DRRDRDREREKENER 362

Query: 346 TPRRGRSHNWSRNPSKERSHSHSRSSSKERDHRGSSSPRKESGRSQSGSPNKQRDHSRSR 405
             RR R ++  R   +E+    SR  SKE+  RG    +K     +     + RD  R  
Sbjct: 363 GRRRDRDYDKERGNEREKERERSRERSKEQRSRGEVEEKKHK---EDKDDRRHRDDKRDS 419

Query: 406 SPNKARDRSRSRSPYKARDRSRSRSPNKARDCSRSRSPYKARDRSRSRSPNKARDHSRSR 465
              K   RSRSR   K R RSRSR+  K    SRSRS  K+     S+  N++++ S  R
Sbjct: 420 KKEKKHSRSRSRER-KHRSRSRSRNAGKR---SRSRSKEKS-----SKHKNESKEKSNKR 470

Query: 466 SPNKARDRSRSRSPSKERDHSQLGSPSKERDHRRSRSPSKERQCRQSRSSSKERD--HRR 523
           S + ++ R+ S   SK+R+HS    PSKE+  +RSR  SKER  ++  S SK++   H R
Sbjct: 471 SRSGSQGRTDSVEKSKKREHS----PSKEKSRKRSR--SKERSHKRDHSDSKDQSDKHDR 524

Query: 524 SRSPSKERQRRQSRSPNKE 542
            RS S E++ ++ +  NK+
Sbjct: 525 RRSQSIEQESQEKQHKNKD 543



 Score =  119 bits (299), Expect = 7e-27
 Identities = 90/292 (30%), Positives = 143/292 (48%), Gaps = 35/292 (11%)

Query: 373 KERDHRGSSSPRKESGRSQSGSPNKQRDHSRSRSPNKARDRSRSRSPYKARDRSRSRSPN 432
           + R  R S SPR+   RS+S S +++   S S      R++ R R   +A++R + R   
Sbjct: 259 RSRSPRRSLSPRRSPRRSRSRSHHREGHGSSSFDRELEREKERQRLEREAKEREKERR-- 316

Query: 433 KARDCSRSRSPYKARDRSRSRSPNKARDHSRSRSPNK-----ARDRSRSRSPSKE----- 482
                 RSRS  +  +R RSRS    R+  RSRS ++      RDR R R    E     
Sbjct: 317 ------RSRSIDRGLERRRSRS----RERHRSRSRSRDRKGDRRDRDREREKENERGRRR 366

Query: 483 -RDHSQLGSPSKERDHRRSRSPSKERQCR---QSRSSSKERDHRR----SRSPSKERQRR 534
            RD+ +     +E++  RSR  SKE++ R   + +   +++D RR     R   KE++  
Sbjct: 367 DRDYDKERGNEREKERERSRERSKEQRSRGEVEEKKHKEDKDDRRHRDDKRDSKKEKKHS 426

Query: 535 QSRS-PNKERDRSQSRSPSEEREHRQSRSPSKERDRRRWRSPSKERERRQSRSSSEERDH 593
           +SRS   K R RS+SR+  +    R     SK ++  + +S  + R   Q R+ S E+  
Sbjct: 427 RSRSRERKHRSRSRSRNAGKRSRSRSKEKSSKHKNESKEKSNKRSRSGSQGRTDSVEKSK 486

Query: 594 SRSRSPNKQSGYSRPRASSKEKAHSRSRTPSKE--GNHSQSRTSSKESDPSQ 643
            R  SP+K+   SR R+ SKE++H R  + SK+    H + R+ S E +  +
Sbjct: 487 KREHSPSKEK--SRKRSRSKERSHKRDHSDSKDQSDKHDRRRSQSIEQESQE 536



 Score =  111 bits (278), Expect = 2e-24
 Identities = 87/270 (32%), Positives = 137/270 (50%), Gaps = 21/270 (7%)

Query: 439 RSRSPYKARDRSRSRSPNKARDHSRSRSPNKARDRSRSRSPSKERDHSQLGSPSKERDHR 498
           RSRSP ++    RS   +++R H R    + + DR   R    E++  +L   +KER+  
Sbjct: 259 RSRSPRRSLSPRRSPRRSRSRSHHREGHGSSSFDRELER----EKERQRLEREAKEREKE 314

Query: 499 RSRSPSKERQCRQSRSSSKERDHRRSRSPSKERQRRQSRSPNKERDRSQSRSPSEEREHR 558
           R RS S +R   + RS S+ER   RSRS  ++  RR     ++ER++   R    +R++ 
Sbjct: 315 RRRSRSIDRGLERRRSRSRERHRSRSRSRDRKGDRRDR---DREREKENERGRRRDRDYD 371

Query: 559 QSRSPSKERDRRRWRSPSKERERRQSRSSSEERDHSRSRSPNKQSGYSRPRASSKEKAHS 618
           + R   +E++R R R  SKE   ++SR   EE+ H   +   +       R S KEK HS
Sbjct: 372 KERGNEREKERERSRERSKE---QRSRGEVEEKKHKEDKDDRRHR--DDKRDSKKEKKHS 426

Query: 619 RSRT-PSKEGNHSQSRTSSKES---DPSQSTVPRSPDWKRSPTRTSSLSQNRT----PSK 670
           RSR+   K  + S+SR + K S      +S+  ++   ++S  R+ S SQ RT     SK
Sbjct: 427 RSRSRERKHRSRSRSRNAGKRSRSRSKEKSSKHKNESKEKSNKRSRSGSQGRTDSVEKSK 486

Query: 671 TSSHSPSTFPSGGQTLSQDDS-QADATTSK 699
              HSPS   S  ++ S++ S + D + SK
Sbjct: 487 KREHSPSKEKSRKRSRSKERSHKRDHSDSK 516



 Score = 82.8 bits (203), Expect = 1e-15
 Identities = 75/272 (27%), Positives = 110/272 (40%), Gaps = 32/272 (11%)

Query: 472 DRSRSRSPSKERDHSQLGSPSKER--DHRRSRSPSKERQCRQSRSSSKERDHRRSRSPSK 529
           D+     P K +   + G+   +R  + RRSRSP +    R+S   S+ R H R    S 
Sbjct: 230 DQQIKTRPRKIKKDGKEGAEEIDRHVERRRSRSPRRSLSPRRSPRRSRSRSHHREGHGSS 289

Query: 530 ERQRRQSRSPNKERDRSQSRSPSEEREHRQSRSPSKERDRRRWRSPSKERERRQSRS-SS 588
              R   R   KER R +  +   E+E R+SRS  +  +RRR RS  + R R +SR    
Sbjct: 290 SFDRELERE--KERQRLEREAKEREKERRRSRSIDRGLERRRSRSRERHRSRSRSRDRKG 347

Query: 589 EERDHSRSRSPNKQSG------YSRPRASSKEKAHSRSRTPSKE---------------- 626
           + RD  R R    + G      Y + R + +EK   RSR  SKE                
Sbjct: 348 DRRDRDREREKENERGRRRDRDYDKERGNEREKERERSRERSKEQRSRGEVEEKKHKEDK 407

Query: 627 ---GNHSQSRTSSKESDPSQSTVPRSPDWKRSPTRTS-SLSQNRTPSKTSSH-SPSTFPS 681
               +    R S KE   S+S         RS +R +   S++R+  K+S H + S   S
Sbjct: 408 DDRRHRDDKRDSKKEKKHSRSRSRERKHRSRSRSRNAGKRSRSRSKEKSSKHKNESKEKS 467

Query: 682 GGQTLSQDDSQADATTSKATLPGERSSSSSSK 713
             ++ S    + D+           S   S K
Sbjct: 468 NKRSRSGSQGRTDSVEKSKKREHSPSKEKSRK 499



 Score = 82.0 bits (201), Expect = 2e-15
 Identities = 88/337 (26%), Positives = 140/337 (41%), Gaps = 34/337 (10%)

Query: 89  RTPSRVSTDTRTSKASKASDVRCHQRRGTHSRGRTPGRRGSRSSKRSPSRASTPGRIRT- 147
           R P  V  +      ++   ++   + G     R   RR SRS +RS S   +P R R+ 
Sbjct: 220 RIPVPVQKNIDQQIKTRPRKIKKDGKEGAEEIDRHVERRRSRSPRRSLSPRRSPRRSRSR 279

Query: 148 --HGARPGMASRVRTPTSQQKGSRGKSYGRPRTSNRERSDSQPRNLSKKSYRPPGGSGIG 205
             H    G +S  R    +++  R +   + R   R RS S  R L ++           
Sbjct: 280 SHHREGHGSSSFDRELEREKERQRLEREAKEREKERRRSRSIDRGLERRR---------S 330

Query: 206 RSSELAVTPSTAKCQTPTGIPSKEKSDNPSPSSSRKVKSYGQMIIPSREKSYSPT-EMSS 264
           RS E   + S ++ +         + +  +    R+ + Y +     REK    + E S 
Sbjct: 331 RSRERHRSRSRSRDRKGDRRDRDREREKENERGRRRDRDYDKERGNEREKERERSRERSK 390

Query: 265 RVKSYNQASTRSRPQSHSQSRSPRRSRSGSQKRTHSRVRSHSWKRNHSRARSRTRKGILS 324
             +S  +   +   +     R     R   +++ HSR RS   +R H R+RSR+R     
Sbjct: 391 EQRSRGEVEEKKHKEDKDDRRHRDDKRDSKKEKKHSRSRSR--ERKH-RSRSRSRNA--- 444

Query: 325 QMGRHSQSRSHSKG-KSQNQSRTPRRGRSHNWSRNPSKERSHSHSRSSSKERDHRGSSSP 383
             G+ S+SRS  K  K +N+S+     RS          RS S  R+ S E+  +   SP
Sbjct: 445 --GKRSRSRSKEKSSKHKNESKEKSNKRS----------RSGSQGRTDSVEKSKKREHSP 492

Query: 384 RKESGRSQSGSPNK--QRDHSRSRSPNKARDRSRSRS 418
            KE  R +S S  +  +RDHS S+  +   DR RS+S
Sbjct: 493 SKEKSRKRSRSKERSHKRDHSDSKDQSDKHDRRRSQS 529



 Score = 81.6 bits (200), Expect = 2e-15
 Identities = 79/326 (24%), Positives = 136/326 (41%), Gaps = 46/326 (14%)

Query: 186 SQPRNLSKKSYRPPGGSGIGRSSELAVTPSTAKCQTPTGIPSKEKSDNPSPSSSRKVKSY 245
           ++PR + K      G   I R  E   + S  +  +P   P + +S +          S+
Sbjct: 235 TRPRKIKKDGKE--GAEEIDRHVERRRSRSPRRSLSPRRSPRRSRSRSHHREGHGS-SSF 291

Query: 246 GQMIIPSREKSYSPTEMSSRVKSYNQAST--------RSRPQSHSQSRSPRRSRSGSQK- 296
            + +   +E+     E   R K   ++ +        RSR +   +SRS  R R G ++ 
Sbjct: 292 DRELEREKERQRLEREAKEREKERRRSRSIDRGLERRRSRSRERHRSRSRSRDRKGDRRD 351

Query: 297 ----------RTHSRVRSHSWKRNHSRARSRTRKGILSQMGRHS---QSRSHSKGKSQNQ 343
                     R   R R +  +R + R + R R    S+  R     + + H + K   +
Sbjct: 352 RDREREKENERGRRRDRDYDKERGNEREKERERSRERSKEQRSRGEVEEKKHKEDKDDRR 411

Query: 344 SRTPRRG--RSHNWSRNPSKERSHSHSRSSSKERDHRGSSSPRKESGRSQSGSPNKQRDH 401
            R  +R   +    SR+ S+ER H  SRS S+    R  S  +++S        +K ++ 
Sbjct: 412 HRDDKRDSKKEKKHSRSRSRERKH-RSRSRSRNAGKRSRSRSKEKS--------SKHKNE 462

Query: 402 SRSRSPNKARDRSRSRSPYKARDRSRSRSPNKARDCSRSRSPYKARDRSRSRSPNKARDH 461
           S+ +S  ++R  S+ R+    + + R  SP+K           K+R RSRS+  +  RDH
Sbjct: 463 SKEKSNKRSRSGSQGRTDSVEKSKKREHSPSKE----------KSRKRSRSKERSHKRDH 512

Query: 462 SRSRSPNKARDRSRSRSPSKERDHSQ 487
           S S+  +   DR RS+S  +E    Q
Sbjct: 513 SDSKDQSDKHDRRRSQSIEQESQEKQ 538



 Score = 51.6 bits (122), Expect = 3e-06
 Identities = 63/249 (25%), Positives = 101/249 (40%), Gaps = 26/249 (10%)

Query: 62  SKSTKSTSTKRAPSNRPSSRSRVRSKARTPSRVSTDTRTSKASKASDVRCHQRRGTHSRG 121
           S+S      +R   +R   RSR RS+ R   R   D    K ++    R   R     RG
Sbjct: 318 SRSIDRGLERRRSRSRERHRSRSRSRDRKGDRRDRDREREKENERG--RRRDRDYDKERG 375

Query: 122 RTPGRRGSRSSKRSPSRASTPGRIRTHGARPGMASRVRTPTSQQKGSRGKSYGRPRTSNR 181
               +   RS +RS  + S  G +     +     R R    ++   + K + R R+  R
Sbjct: 376 NEREKERERSRERSKEQRSR-GEVEEKKHKEDKDDR-RHRDDKRDSKKEKKHSRSRSRER 433

Query: 182 E-RSDSQPRNLSKKSYRPPGGSGIGRSSELAVTPSTAKCQTPTGIPSKEKSDNPSPSSSR 240
           + RS S+ RN  K+S          RS E +               SKEKS+  S S S 
Sbjct: 434 KHRSRSRSRNAGKRSR--------SRSKEKSSKHKN---------ESKEKSNKRSRSGS- 475

Query: 241 KVKSYGQMIIPSREKSYSPTEMSSRVKSYNQASTRSRPQSHSQSRSPRRSRSGSQK-RTH 299
             +     +  S+++ +SP++  SR +S ++  +  R  S S+ +S +  R  SQ     
Sbjct: 476 --QGRTDSVEKSKKREHSPSKEKSRKRSRSKERSHKRDHSDSKDQSDKHDRRRSQSIEQE 533

Query: 300 SRVRSHSWK 308
           S+ + H  K
Sbjct: 534 SQEKQHKNK 542



 Score = 32.0 bits (71), Expect = 2.1
 Identities = 28/116 (24%), Positives = 45/116 (38%), Gaps = 1/116 (0%)

Query: 25  DPKPPASLKSTKSATPNRSLVPTKPATSRNSVMSPSSSKSTKSTSTKRAPSNRPSSRSRV 84
           D K  +  +   S + +R       + SRN+     S    KS+  K     + + RSR 
Sbjct: 414 DDKRDSKKEKKHSRSRSRERKHRSRSRSRNAGKRSRSRSKEKSSKHKNESKEKSNKRSRS 473

Query: 85  RSKARTPSRVSTDTRTSKASK-ASDVRCHQRRGTHSRGRTPGRRGSRSSKRSPSRA 139
            S+ RT S   +  R    SK  S  R   +  +H R  +  +  S    R  S++
Sbjct: 474 GSQGRTDSVEKSKKREHSPSKEKSRKRSRSKERSHKRDHSDSKDQSDKHDRRRSQS 529


>gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]
          Length = 1301

 Score =  137 bits (344), Expect = 5e-32
 Identities = 170/713 (23%), Positives = 245/713 (34%), Gaps = 25/713 (3%)

Query: 2    SSPKRSSKPSMSLAPSGSSMPTADPKPPASLKSTKSATPNRSLVPTKPATSRNSVMSPSS 61
            SS   SS  S S   S SS   +     +S   +  +  + S       +S +S  S SS
Sbjct: 549  SSDSDSSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSS 608

Query: 62   SKSTKSTSTKRAPSNRPSSRSRVRSKARTPSRVSTDTRTSKASKASDVRCHQRRGTHSRG 121
              S  S S+  + S   SS+S   S        S+D+ +S +S  SD        + S  
Sbjct: 609  DSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSD-------SSDSSN 661

Query: 122  RTPGRRGSRSSKRSPSRASTPGRIRTHGARPGMASRVRTPTSQQKGSRGKSYGRPRTSNR 181
             +     S SS  S S +S+     +  +    +S     +     S   S     +SN 
Sbjct: 662  SSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNS 721

Query: 182  ERSDSQPRNLSKKSYRPPGGSGIGRSSELAVTPSTAKCQTPTGIPSKEKSDNPSPSSSRK 241
              SDS   N S  S           S     + S+    +     S + SD+   S S  
Sbjct: 722  NSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDS-- 779

Query: 242  VKSYGQMIIPSREKSYSPTEMSSRVKSYNQASTRSRPQSHSQSRSPRRSRSGSQKRTHSR 301
                      +   S   +  S    S N + + +   S   S S     S S   ++S 
Sbjct: 780  ---------SNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSS 830

Query: 302  VRSHSWKRNHSRARSRTRKGILSQMGRHSQS--RSHSKGKSQNQSRTPRRGRSHNWSRNP 359
              S S   + S   S +  G  S     S S   S S   S + + +     S +   + 
Sbjct: 831  DSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSN 890

Query: 360  SKERSHSHSRSSSKERDHRGSSSPRKESGRSQSGSPNKQRDHSRSRSPNKARDRSRSRSP 419
            S + S S + S S   D   SS     S  S S   +   D+S S   + + D S S   
Sbjct: 891  SSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDS 950

Query: 420  YKARDRSRSRSPNKARDCSRSRSPYKARDRSRSRSPNKARDHSRSRSPNKARDRSRSRSP 479
              + D S S   + + D S S S     D S S + + + D S S   + + D S S   
Sbjct: 951  SNSSDSSNSSDSSNSSDSSDSNS----SDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDS 1006

Query: 480  SKERDHSQLGSPSKERDHRRSRSPSKERQCRQSRSSSKERDHRRSRSPSKERQRRQSRSP 539
            S   D S   + S   +   S + S       S  SS   D   S   S       S   
Sbjct: 1007 SDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDS 1066

Query: 540  NKERDRSQSRSPSEEREHRQSRSPSKERDRRRWRSPSKERERRQSRSSSEERDHSRSRSP 599
            +   D S S   S+  E   S   S   D       S   +   S  SS+  D S S   
Sbjct: 1067 SDSSDSSDSSDSSDSSESSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDS 1126

Query: 600  NKQSGYSRPRASSKEKAHSRSRTPSKEGNHSQSRTSSKESDPSQSTVPRSPDWKRSPTRT 659
            +  S  S    SS     S S   S   + S S  SS  SD S S+   S     S +  
Sbjct: 1127 SDSSDSSDSSDSSNSSDSSDSSESSDSSDSSDSSDSSDSSDSSDSS-DSSDSSNSSDSSD 1185

Query: 660  SSLSQNRTPSKTSSHSPSTFPSGGQTLSQDDSQADATTSKATLPGERSSSSSS 712
            SS S + + S  SS S  +  S   + S D S +  ++  +       SS SS
Sbjct: 1186 SSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSNESSDSS 1238



 Score =  135 bits (340), Expect = 1e-31
 Identities = 166/710 (23%), Positives = 259/710 (36%), Gaps = 40/710 (5%)

Query: 2    SSPKRSSKPSMSLAPSGSSMPTADPKPPASLKSTKSATPNRSLVPTKPATSRNSVMSPSS 61
            SS    SK   S + S SS   +D K  +S  ++  ++ N     +  + S NS  S  S
Sbjct: 616  SSDSSDSKSDSSKSESDSS--DSDSKSDSSDSNSSDSSDNSD--SSDSSNSSNSSDSSDS 671

Query: 62   SKSTKSTSTKRAPSNRPSSRSRVRSKARTPSRVSTDTRTSKASKASDVRCHQRRGTHSRG 121
            S S+ S+S+  + ++  SS S   S + + S  S+D+  S +S +SD        + S  
Sbjct: 672  SDSSDSSSSSDSSNSSDSSDSSDSSNS-SESSDSSDSSDSDSSDSSDSSNSNSSDSDSSN 730

Query: 122  RTPGRRGSRSSKRSPSRASTPGRIRTHGARPGMASRVRTPTSQQKGSRGKSYGRPRTSNR 181
             +     S SS  S S  S+                  + +S    S   S     + + 
Sbjct: 731  SSDSSDSSNSSDSSDSSDSSNS----------------SDSSDSSDSSNSSDSSDSSDSS 774

Query: 182  ERSDSQPRNLSKKSYRPPGGSGIGRSSELAVTPSTAKCQTPTGIPSKEKSDNPSPSSSRK 241
            + SDS   + S  S      S    SS+ + +  ++     +   S   SD+ + S S  
Sbjct: 775  DSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSD 834

Query: 242  VKSYGQMIIPSREKSYSPTEMSSRVKSYNQASTRSRPQSHSQSRSPRRSRSGSQKRTHSR 301
              +       S     S ++ S+R  S N  S+ S   S S + S     S S + ++S 
Sbjct: 835  SSNSSDSSDSSDSSDGSDSDSSNRSDSSN--SSDSSDSSDSSNSSDSSDSSDSNESSNSS 892

Query: 302  VRSHSWKRNHSRARSRTRKGILSQMGRHSQSRSHSKGKSQNQSRTPRRGRSHNWSRNPSK 361
              S S   + S +         S     S   S+S   S++ + +     S + + + S 
Sbjct: 893  DSSDSSNSSDSDSSD-------SSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSS 945

Query: 362  ERSHSHSRSSSKERDHRGSSSPRKESGRSQSGSPNKQRDHSRSRSPNKARDRSRSRSPYK 421
            + S S + S S       +SS   +S  S S   +   D S S   + + D S S +   
Sbjct: 946  DSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSD 1005

Query: 422  ARDRSRSRSPNKARDCSRSRSPYKARDRSRSRSPNKARDHSRSRSPNKARDRSRSRSPSK 481
            + D S S   + + D S S     + D S S   + + D S S   + + + S S   S 
Sbjct: 1006 SSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSD 1065

Query: 482  ERDHSQLGSPSKERDHRRSRSPSKERQCRQSRSSSKERDHRRSRSPSKERQRRQSRSPNK 541
              D S     S   D   S   S       S  SS   D   S   S       S + + 
Sbjct: 1066 SSDSSDSSDSSDSSDSSESSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSD 1125

Query: 542  ERDRSQSRSPSEEREHRQSRSPSKERDRRRWRSPSKERERRQSRSSSEERDHSRSRSPNK 601
              D S S   S+      S   S+  D       S   +   S  SS+  D S S   + 
Sbjct: 1126 SSDSSDSSDSSDSSNSSDSSDSSESSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSD 1185

Query: 602  QSGYSRPRASSKEKAHSRSRTPSKEGNHSQSRTSSKESDPSQSTVPRSPDWKRSPTRTSS 661
             S  S    SS     S S   S   + S S  SS  SD S S          S +  SS
Sbjct: 1186 SSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDS----------SDSNESS 1235

Query: 662  LSQNRTPSKTSSHSPSTFPSGGQTLSQDDSQADATTSKATLPGERSSSSS 711
             S + + S  SS+S  +  S   + S  DS  ++ +   +  G  + S S
Sbjct: 1236 DSSDSSDSSDSSNSSDSSDSSDSSDSTSDSNDESDSQSKSGNGNNNGSDS 1285



 Score =  114 bits (286), Expect = 2e-25
 Identities = 157/690 (22%), Positives = 237/690 (34%), Gaps = 44/690 (6%)

Query: 54  NSVMSPSSSKSTKSTSTKRAPSNRPSSRSRVRSKARTPSRVSTDTRTSKASKASDVRCHQ 113
           N V    +SKS ++++    P +  S R     K         + R +K S+   V   Q
Sbjct: 315 NEVDGDKTSKSEENSAG--IPEDNGSQRIEDTQKLNHRESKRVENRITKESETHAVGKSQ 372

Query: 114 RRGTHSRGRTPGRRG----------SRSSKRSPSRASTPGRIRTHGARPGMASRVRTPTS 163
            +G   +G + G R            +  K         G ++T G        V     
Sbjct: 373 DKGIEIKGPSSGNRNITKEVGKGNEGKEDKGQHGMILGKGNVKTQG------EVVNIEGP 426

Query: 164 QQKGSRGKSYGRPRTSNRERSDSQPR-NLSKKSYR--PPGGSGIGRSSELAVTPS--TAK 218
            QK   G   G   T +   SD     +   KS +   P  S     ++ A + S   + 
Sbjct: 427 GQKSEPGNKVGHSNTGSDSNSDGYDSYDFDDKSMQGDDPNSSDESNGNDDANSESDNNSS 486

Query: 219 CQTPTGIPSKEKSDNPSPSSSRKVKS----------------YGQMIIPSREKSYSPTEM 262
            +      S E  DN + S S+  +                  G       +KS S    
Sbjct: 487 SRGDASYNSDESKDNGNGSDSKGAEDDDSDSTSDTNNSDSNGNGNNGNDDNDKSDSGKGK 546

Query: 263 SSRVKSYNQASTRSRPQSHSQSRSPRRSRSGSQKRTHSRVRSHSWKRNHSRARSRTRKGI 322
           S    S +  S+ S   S S       S S S   +     S S   + S + + +    
Sbjct: 547 SDSSDSDSSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSD 606

Query: 323 LSQMGRHSQSRSHSKGKSQNQSRTPRRGRSHNWSRNPSKERSHSHSRSSSKERDHRGSSS 382
            S     S S   S  KS   S       S + S++ S + + S S  +S   D   SS+
Sbjct: 607 SSDSSDSSDSSDSSDSKS--DSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSN 664

Query: 383 PRKESGRSQSGSPNKQRDHSRSRSPNKARDRSRSRSPYKARDRSRSRSPNKARDCSRSRS 442
               S  S S   +   D S S   + + D S S     + D S S S + +   + + S
Sbjct: 665 SSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSS 724

Query: 443 PYKARDRSRSRSPNKARDHSRSRSPNKARDRSRSRSPSKERDHSQLGSPSKERDHRRSRS 502
              + + S S   + + D S S   + + D S S   S   D S     S   D   S  
Sbjct: 725 DSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSD 784

Query: 503 PSKERQCRQSRSSSKERDHRRSRSPSKERQRRQSRSPNKERDRSQSRSPSEEREHRQSRS 562
            +       S  SS   D   S   S       S S N   D S S   S+      S  
Sbjct: 785 SNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSS-DSSNSSDSSDSSNSSDSSD 843

Query: 563 PSKERDRRRWRSPSKERERRQSRSS-SEERDHSRSRSPNKQSGYSRPRASSKEKAHSRSR 621
            S   D     S ++      S SS S +  +S   S +  S  S   + S + ++S   
Sbjct: 844 SSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDS 903

Query: 622 TPSKEGNHSQSRTSSKESDPSQSTVPRSPDWKRSPTRTSSLSQNRTPSKTSSHSPSTFPS 681
             S   N S S  SS  SD S+S+   S +   S +  SS S + + S  SS S ++  S
Sbjct: 904 DSSDSSNSSDSSDSSNSSDSSESS-NSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDS 962

Query: 682 GGQTLSQDDSQADATTSKATLPGERSSSSS 711
              + S D + +D++ S  +     SS SS
Sbjct: 963 SNSSDSSDSNSSDSSDSSNSSDSSDSSDSS 992



 Score =  113 bits (282), Expect = 7e-25
 Identities = 150/673 (22%), Positives = 231/673 (34%), Gaps = 36/673 (5%)

Query: 58   SPSSSKSTKSTSTKRAPSNRPSSRSRVRSKARTPSRVSTDTRTSKASKASDVRCHQRRGT 117
            S S+S +  S S     +    +      K ++ S  S  + +S +S +SD        +
Sbjct: 515  SDSTSDTNNSDSNGNGNNGNDDNDKSDSGKGKSDSSDSDSSDSSNSSDSSDSSDSDSSDS 574

Query: 118  HSRGRTPGRRGSRSSKRSPSRASTPGRIRTHGARPGMASRVRTPTSQQKGSRGKSYGRPR 177
            +S   +       S       + +     +  +     S   + +S  K    KS     
Sbjct: 575  NSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSS 634

Query: 178  TSNRERSDSQPRNLSKKSYRPPGGSGIGRSSELAVTPSTAKCQTPTGIPSKEKSDNP--- 234
             S+  +SDS   N S  S                 + S+    +     S + SD+    
Sbjct: 635  DSD-SKSDSSDSNSSDSSDN---------------SDSSDSSNSSNSSDSSDSSDSSDSS 678

Query: 235  --------SPSSSRKVKSYGQMIIPSREKSYSPTEMSSRVKSYNQASTRSRPQSHSQSRS 286
                    S SS     S       S + S S +  SS   + N + + S   S S   S
Sbjct: 679  SSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSS 738

Query: 287  PRRSRSGSQKRTHSRVRSHSWKRNHSRARSRTRKGILSQMGRHS-----QSRSHSKGKSQ 341
                 S S   ++S   S S   ++S   S +     S    +S      S S     S 
Sbjct: 739  NSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSS 798

Query: 342  NQSRTPRRGRSHNWSRNPSKERSHSHSRSSSKERDHRGSSSPRKESGRSQSGSPNKQRDH 401
            N S +     S + S +   + S+S   S+S +     +SS   +S  S  GS +   + 
Sbjct: 799  NSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNR 858

Query: 402  SRSRSPNKARDRSRSRSPYKARDRSRSRSPNKARDCSRS--RSPYKARDRSRSRSPNKAR 459
            S S + + + D S S +   + D S S   + + D S S   S   + D S S   + + 
Sbjct: 859  SDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSS 918

Query: 460  DHSRSRSPNKARDRSRSRSPSKERDHSQLGSPSKERDHRRSRSPSKERQCRQSRSSSKER 519
            + S S   + + D S S   S   D S     S   D   S   S       S SS    
Sbjct: 919  NSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSS- 977

Query: 520  DHRRSRSPSKERQRRQSRSPNKERDRSQSRSPSEEREHRQSRSPSKERDRRRWRSPSKER 579
            D   S   S       S   +   + S S   S+  +   S   S   D       S   
Sbjct: 978  DSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSS 1037

Query: 580  ERRQSRSSSEERDHSRSRSPNKQSGYSRPRASSKEKAHSRSRTPSKEGNHSQSRTSSKES 639
            +   S  SS+  D S S + +  S  S    SS     S S   S+  + S S  SS  S
Sbjct: 1038 DSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDSSNSSDSS 1097

Query: 640  DPSQSTVPRSPDWKRSPTRTSSLSQNRTPSKTSSHSPSTFPSGGQTLSQDDSQADATTSK 699
            D S S+   S     S +  SS S N + S  SS S  +  S   + S D S++  ++  
Sbjct: 1098 DSSDSS-DSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSSDSSESSDSSDS 1156

Query: 700  ATLPGERSSSSSS 712
            +       SS SS
Sbjct: 1157 SDSSDSSDSSDSS 1169



 Score = 54.3 bits (129), Expect = 4e-07
 Identities = 82/369 (22%), Positives = 136/369 (36%), Gaps = 16/369 (4%)

Query: 2    SSPKRSSKPSMSLAPSGSSMPTADPKPPASLKSTKSATPNRSLVPTKPATSRNSVMSPSS 61
            SS   +S  S + + S +S  ++D     S  S+ S+  + S   +  + S +S  S  S
Sbjct: 947  SSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDS 1006

Query: 62   SKSTKSTSTKRAPSNRPSSRSRVRSKARTPSRVSTDTRTSKASKASDVRCHQRRGTHSRG 121
            S S+ S+ +  +  +  SS S   S +   S  S  + +S +S +SD          S  
Sbjct: 1007 SDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDSSD----------SSN 1056

Query: 122  RTPGRRGSRSSKRSPSRASTPGRIRTHGARPGMASRVRTPTSQQKGSRGKSYGRPRTSNR 181
             +     S SS  S S  S+     +  +    +S     +S    S   S     + + 
Sbjct: 1057 SSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDSSN----SSDSSDSSDSSDSSDSSDSS 1112

Query: 182  ERSDSQPRNLSKKSYRPPGGSGIGRSSELAVTPSTAKCQTPTGIPSKEKSDNPSPSSSRK 241
            + SDS   + S  S      S    SS  + +  +++    +       S + S SS   
Sbjct: 1113 DSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSSDSSESSDSSDSSDSSDSSDSSDSSDSS 1172

Query: 242  VKSYGQMIIPSREKSYSPTEMSSRVKSYNQASTRSRPQSHSQSRSPRRSRSGSQKRTHSR 301
              S       S + S S     S   S +  S+ S   S S   S     S S   + S 
Sbjct: 1173 DSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSN 1232

Query: 302  VRSHSWKRNHSRARSRTRKGILSQMGRHSQSRSHSKGKSQNQSRTPRRGRSHNWSRNPSK 361
              S S   + S   S +     S     S S S S  +S +QS++     + + S + S+
Sbjct: 1233 ESSDSSDSSDSSDSSNSSDS--SDSSDSSDSTSDSNDESDSQSKSGNGNNNGSDSDSDSE 1290

Query: 362  ERSHSHSRS 370
                +HS S
Sbjct: 1291 GSDSNHSTS 1299



 Score = 38.9 bits (89), Expect = 0.017
 Identities = 71/363 (19%), Positives = 122/363 (33%), Gaps = 31/363 (8%)

Query: 370 SSSKERDHRGSSSPRKESGRSQSGSPN-KQRDHSRSRSPNKAR----DRSRSRSPYKARD 424
           S   E +  G+      + + Q G  + K+ DH  S   N       D      P+   D
Sbjct: 259 SGDDEDEEAGNGKDSSNNSKGQEGQDHGKEDDHDSSIGQNSDSKEYYDPEGKEDPHNEVD 318

Query: 425 -----RSRSRSPNKARD--CSRSRSPYKARDRSRSRSPNKARDHSRSRSPNKARDR---- 473
                +S   S     D    R     K   R   R  N+    S + +  K++D+    
Sbjct: 319 GDKTSKSEENSAGIPEDNGSQRIEDTQKLNHRESKRVENRITKESETHAVGKSQDKGIEI 378

Query: 474 ----SRSRSPSKERDHSQLGSPSKERDHRRSRSPSKERQCRQSRSSSKERDHRRSRSPSK 529
               S +R+ +KE      G+  KE   +      K     Q    + E   ++S   +K
Sbjct: 379 KGPSSGNRNITKEVGK---GNEGKEDKGQHGMILGKGNVKTQGEVVNIEGPGQKSEPGNK 435

Query: 530 ERQRRQSRSPNKER-DRSQSRSPSEEREHRQSRSPSKERDRRRWRSPSKERERRQSRSSS 588
                     N +  D       S + +   S   S   D     S +    R  +  +S
Sbjct: 436 VGHSNTGSDSNSDGYDSYDFDDKSMQGDDPNSSDESNGNDDANSESDNNSSSRGDASYNS 495

Query: 589 EERDHSRSRSPNKQSGYSRPRASSKEKAHSRSRTPSKEGNHSQSRTSSKESDPSQSTVPR 648
           +E   + + S +K +            + S +      GN +     + +SD  +     
Sbjct: 496 DESKDNGNGSDSKGA------EDDDSDSTSDTNNSDSNGNGNNGNDDNDKSDSGKGK-SD 548

Query: 649 SPDWKRSPTRTSSLSQNRTPSKTSSHSPSTFPSGGQTLSQDDSQADATTSKATLPGERSS 708
           S D   S +  SS S + + S +S  + S+      + S D S +D++ S  +     SS
Sbjct: 549 SSDSDSSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSS 608

Query: 709 SSS 711
            SS
Sbjct: 609 DSS 611


>gi|50083281 KIAA1853 protein [Homo sapiens]
          Length = 611

 Score =  125 bits (315), Expect = 1e-28
 Identities = 144/532 (27%), Positives = 216/532 (40%), Gaps = 89/532 (16%)

Query: 252 SREKSYSPTEMSSRVKSYNQASTRSRPQSHSQSRSPRRSRSGSQKRTHSRVRSHSWKRNH 311
           S +K  +P   S   K   +++ + R +S S S SP + +     + H R RS S KR H
Sbjct: 95  SHDKDLTPPPSSRGKKKKKKSTRKKRRRSSSYSPSPVKKKKKKSSKKHKRRRSFSKKRRH 154

Query: 312 SRARSRTRKGILSQMGRHSQSRSHSKGKSQNQSRTPRRGRSHNWSRNPSKERSHSHSRSS 371
           S +  ++++            R   + K Q++SR PR+   H   R PS+ +S S SR S
Sbjct: 155 SSSSPKSKR------------RDEKRHKKQSRSR-PRKSHRHRHHRCPSRSQS-SESRPS 200

Query: 372 SKERDHRGSS------SPRKESGRSQSGSPNKQRDHSRSRSPNK---------------- 409
           S E  HRG S      S R+ S R          +   SR P++                
Sbjct: 201 SCESRHRGRSPEEGQKSRRRHSRRCSKTLCKDSPEAQSSRPPSQPLQMLGYLSARGVITG 260

Query: 410 ---ARDRSRSRSPYKARDRSRSRSPNKARDCSRSRSPYKARDRSRSR---SPNKARDHSR 463
              A D     +      R RS+  +   D S   S   +  RSR +   SP+     SR
Sbjct: 261 SGSAADLFTKTASPLTTSRGRSQEYDSGNDTSSPPSTQTSSARSRGQEKGSPSGGLSKSR 320

Query: 464 SRSPNKARDRSRSRSPSKERDHS----QLGSPSKERDHRRSRSPSKE------------- 506
             +     D   S + S  ++       L   S+ R+ R  +SP  E             
Sbjct: 321 ELNSGNTSDSGNSFTTSSPQNKGAMLENLSPTSRGRESRGFQSPCLECAEVKKSSLVPST 380

Query: 507 ------RQCRQSRSSSKERDHRRS-RSPSKERQRR--QSRSPNKERDRSQSRSPSEEREH 557
                 + C +S S +  R    S RSP+     R  QSRS + E+ RS SRSPS   + 
Sbjct: 381 ARSSPMKGCSRSSSYASTRSSSHSSRSPNPRASPRYTQSRSTSSEK-RSYSRSPSYSSKS 439

Query: 558 RQSRSPSKERDRRRWRS-----PSKERERRQSRSSSEERDHSRSR------SPNKQSGYS 606
            +   PS+    RR  S     PS+ER+ + S   S++R+  R+R      SP ++    
Sbjct: 440 GKRSPPSRSSRSRRSPSYSRYSPSRERDPKYSEKDSQQRERERARRRRRSYSPMRKRRRD 499

Query: 607 RP------RASSKEKAHSRSRTPSKEGNHSQSRTSSKESDPSQSTVPRSPDWKRSPTRTS 660
            P      R +S  K       PS   + S S TSS  S  S  +  RS    RS +R+ 
Sbjct: 500 SPSHLEARRITSARKRPIPYYRPSPSSSGSLSSTSSWYSSSSSRSASRSYSRSRSRSRSR 559

Query: 661 SLSQNRTPSKTSSHSPSTFPSGGQTLSQDDSQADATTSKATLPGERSSSSSS 712
             S+ RT S +SS SPS    G ++ S+  S++ + +   +     + S SS
Sbjct: 560 RRSRTRTSSSSSSRSPS---PGSRSRSRSRSRSRSRSRSQSRSYSSADSYSS 608



 Score =  119 bits (298), Expect = 1e-26
 Identities = 174/669 (26%), Positives = 264/669 (39%), Gaps = 95/669 (14%)

Query: 1   MSSPKRSSKPSMSLAPSGSSMPTADPKPPASLKSTKSATPNRSLVPTKPATSRNSVMSPS 60
           M+S ++  K        G+    A P+P + + +  S T  + L  T+P    N V+   
Sbjct: 1   MASVQQGEKQLFEKFWRGTFKAVATPRPESIIVA--SITARKPLPRTEP--QNNPVVPAQ 56

Query: 61  SSKSTK-----------STSTKRAPSNRPSSRSRVRSKARTPSRVSTDTRTSKASKASDV 109
              S K           + S +R  + R    +R  S +         +   K  K    
Sbjct: 57  DGPSEKLGQHLATEPLGTNSWERDKTCRELGATRGHSASHDKDLTPPPSSRGKKKKKKST 116

Query: 110 RCHQRRGTHSRGRTPGRRGSRSSKRSPSRASTPGRIRTHGARPGMASRVRTPTSQQKGSR 169
           R  +RR +        ++  +SSK+   R S   + R   + P    R       +K  +
Sbjct: 117 RKKRRRSSSYSPSPVKKKKKKSSKKHKRRRSFSKKRRHSSSSPKSKRR------DEKRHK 170

Query: 170 GKSYGRPRTSNRERSDSQPRNLSKKSYRPPGGSGIGRSSELAVTPSTAKCQTPTGIPSKE 229
            +S  RPR S+R R    P        RP                  + C++     S E
Sbjct: 171 KQSRSRPRKSHRHRHHRCPSRSQSSESRP------------------SSCESRHRGRSPE 212

Query: 230 KSDNPSPSSSRKVKSYGQMIIPSREKSYSPTEMSSRVKSYNQA-----STRSRPQSHSQS 284
           +        SR+         P  + S  P++   ++  Y  A      + S     +++
Sbjct: 213 EGQKSRRRHSRRCSKTLCKDSPEAQSSRPPSQ-PLQMLGYLSARGVITGSGSAADLFTKT 271

Query: 285 RSP-RRSRSGSQKRTHSRVRSHSWKRNHSRARSRTRKGILSQMGRHSQSRSHSKGKSQNQ 343
            SP   SR  SQ+       S       S ARSR ++       + S S   SK +  N 
Sbjct: 272 ASPLTTSRGRSQEYDSGNDTSSPPSTQTSSARSRGQE-------KGSPSGGLSKSRELNS 324

Query: 344 SRTPRRGRSHNWSRNPSKERSHSHSRSSSKERDHRGSSSPRKESGRSQSGS--PNKQRDH 401
             T   G S   S   +K     +   +S+ R+ RG  SP  E    +  S  P+  R  
Sbjct: 325 GNTSDSGNSFTTSSPQNKGAMLENLSPTSRGRESRGFQSPCLECAEVKKSSLVPSTARSS 384

Query: 402 SR---SRSPNKARDRSRSRSPYKARDRSRSRSPNKARDCSRSRSPYKARDRSRSRSPNKA 458
                SRS + A  RS S S       SRS +P  +   ++SRS   +  RS SRSP+ +
Sbjct: 385 PMKGCSRSSSYASTRSSSHS-------SRSPNPRASPRYTQSRST-SSEKRSYSRSPSYS 436

Query: 459 RDHSRSRSPNKARDRSRSRSPSKERDHSQLGSPSKERDHRRSRSPSKERQCRQSRSSSKE 518
              S  RSP     RSR RSPS  R      SPS+ERD + S   S++R+  ++R     
Sbjct: 437 -SKSGKRSPPSRSSRSR-RSPSYSRY-----SPSRERDPKYSEKDSQQRERERARR---- 485

Query: 519 RDHRRSRSPSKERQRRQSRSPNKERDRSQSR---------SPS-----EEREHRQSRSPS 564
              RRS SP ++R RR S S  + R  + +R         SPS            S S S
Sbjct: 486 --RRRSYSPMRKR-RRDSPSHLEARRITSARKRPIPYYRPSPSSSGSLSSTSSWYSSSSS 542

Query: 565 KERDRRRWRSPSKERERRQSRSSSEERDHSRSRSPNKQSGYSRPRASSKEKAHSRSRTPS 624
           +   R   RS S+ R RR+SR+ +     SRS SP  +S  SR R+ S+ ++ S+SR+ S
Sbjct: 543 RSASRSYSRSRSRSRSRRRSRTRTSSSSSSRSPSPGSRS-RSRSRSRSRSRSRSQSRSYS 601

Query: 625 KEGNHSQSR 633
              ++S +R
Sbjct: 602 SADSYSSTR 610



 Score =  113 bits (283), Expect = 5e-25
 Identities = 153/515 (29%), Positives = 215/515 (41%), Gaps = 96/515 (18%)

Query: 228 KEKSDNPSPSSSRKVKSYGQ-----MIIPSREKSYSPTEMSSRVKSYNQASTRSRPQS-- 280
           +  S +PSP   +K KS  +          R  S S  +   R +  ++  +RSRP+   
Sbjct: 122 RSSSYSPSPVKKKKKKSSKKHKRRRSFSKKRRHSSSSPKSKRRDEKRHKKQSRSRPRKSH 181

Query: 281 -HSQSRSPRRSRSG--------SQKRTHSRVRSHSWKRNHSRARSRT------------- 318
            H   R P RS+S         S+ R  S       +R HSR  S+T             
Sbjct: 182 RHRHHRCPSRSQSSESRPSSCESRHRGRSPEEGQKSRRRHSRRCSKTLCKDSPEAQSSRP 241

Query: 319 ------RKGILSQMGRHSQSRSHSKGKSQNQSR-TPRRGRSHNW------SRNPSKERSH 365
                   G LS  G  + S S +   ++  S  T  RGRS  +      S  PS + S 
Sbjct: 242 PSQPLQMLGYLSARGVITGSGSAADLFTKTASPLTTSRGRSQEYDSGNDTSSPPSTQTSS 301

Query: 366 SHSRSSSKERDHRGSSSPRK-------ESGRS-QSGSPNKQRDHSRSRSPNKARDRSRS- 416
           + SR   K     G S  R+       +SG S  + SP  +     + SP      SR  
Sbjct: 302 ARSRGQEKGSPSGGLSKSRELNSGNTSDSGNSFTTSSPQNKGAMLENLSPTSRGRESRGF 361

Query: 417 RSPYK--ARDRSRSRSPNKARD-----CSRSRSPYKARDRSRS-RSPNKARD--HSRSRS 466
           +SP    A  +  S  P+ AR      CSRS S    R  S S RSPN      +++SRS
Sbjct: 362 QSPCLECAEVKKSSLVPSTARSSPMKGCSRSSSYASTRSSSHSSRSPNPRASPRYTQSRS 421

Query: 467 PNKARDRSRSRSPSKERDHSQLGSPSKERDHRRSRS-----PSKERQCRQSRSSSKERDH 521
            +  + RS SRSPS      +   PS+    RRS S     PS+ER  + S   S++R+ 
Sbjct: 422 TSSEK-RSYSRSPSYSSKSGKRSPPSRSSRSRRSPSYSRYSPSRERDPKYSEKDSQQRER 480

Query: 522 RRSRSPSKERQRRQSRSPNKERDRSQSRSPSEEREHRQSRSPSKERDRR-RWRSPSKERE 580
            R+R      +RR+S SP ++R R    SPS    H ++R  +  R R   +  PS    
Sbjct: 481 ERAR------RRRRSYSPMRKRRRD---SPS----HLEARRITSARKRPIPYYRPSPSSS 527

Query: 581 RRQSRSSSEERDHSRSRSPNKQSGYSRPRASSKEKAHSRSRTPSKEGNHSQSRTSSKESD 640
              S +SS    +S S S +    YSR R+ S+ +  SR            +RTSS  S 
Sbjct: 528 GSLSSTSSW---YSSSSSRSASRSYSRSRSRSRSRRRSR------------TRTSSSSSS 572

Query: 641 PSQSTVPRSPDWKRSPTRTSSLSQNRTPSKTSSHS 675
            S S   RS    RS +R+ S SQ+R+ S   S+S
Sbjct: 573 RSPSPGSRSRSRSRSRSRSRSRSQSRSYSSADSYS 607



 Score = 76.3 bits (186), Expect = 9e-14
 Identities = 93/319 (29%), Positives = 142/319 (44%), Gaps = 40/319 (12%)

Query: 11  SMSLAPSGSSMPTADPKPPASLKSTKSATPN--RSLVPTKP----ATSRNSVMSPSSSKS 64
           S + + SG+S  T+ P+   ++    S T     S     P    A  + S + PS+++S
Sbjct: 324 SGNTSDSGNSFTTSSPQNKGAMLENLSPTSRGRESRGFQSPCLECAEVKKSSLVPSTARS 383

Query: 65  TKSTSTKRAPSNRPSSRSRVRSKARTPSRVSTDTRTSKASKASDVRCHQRRGTHSRGRTP 124
           +      R+ S+  S+RS   S +R+P+  ++   T   S +S+ R + R  ++S     
Sbjct: 384 SPMKGCSRS-SSYASTRSSSHS-SRSPNPRASPRYTQSRSTSSEKRSYSRSPSYS----- 436

Query: 125 GRRGSRSSKRSPSRASTPGRIRTHGARPGMASRVRTPTSQQKGSRGKSYGRPRTSNRERS 184
               S+S KRSP   S+  R R+        SR R P   +K S+ +   R R   R RS
Sbjct: 437 ----SKSGKRSPPSRSSRSR-RSPSYSRYSPSRERDPKYSEKDSQQRE--RERARRRRRS 489

Query: 185 DSQPRNLSKKSYRPPGGSGIGRSSELAVTPSTAKCQTPTGIPSKEKSDNPSPSSSRKVKS 244
            S  R   + S            S L     T+  + P  IP       PSPSSS  + S
Sbjct: 490 YSPMRKRRRDS-----------PSHLEARRITSARKRP--IPYYR----PSPSSSGSLSS 532

Query: 245 YGQMIIPSREKSYSPTEMSSRVKSYNQASTRSRPQSHSQSRSPR---RSRSGSQKRTHSR 301
                  S  +S S +   SR +S ++  +R+R  S S SRSP    RSRS S+ R+ SR
Sbjct: 533 TSSWYSSSSSRSASRSYSRSRSRSRSRRRSRTRTSSSSSSRSPSPGSRSRSRSRSRSRSR 592

Query: 302 VRSHSWKRNHSRARSRTRK 320
            RS S   + + + S TR+
Sbjct: 593 SRSQSRSYSSADSYSSTRR 611



 Score = 32.7 bits (73), Expect = 1.2
 Identities = 33/99 (33%), Positives = 50/99 (50%), Gaps = 9/99 (9%)

Query: 4   PKRSSKPSMSLAPSGSSMPTADPKPPASLKSTKSATPNRSLVPTKPATSRNSVMSPSSSK 63
           P  SS  S+S   S SS  ++     AS   ++S + +RS   ++  TS     S SSS+
Sbjct: 522 PSPSSSGSLS---STSSWYSSSSSRSASRSYSRSRSRSRSRRRSRTRTS-----SSSSSR 573

Query: 64  STKSTSTKRAPSNRPSSRSRVRSKARTPSRVSTDTRTSK 102
           S    S  R+ S R  SRSR RS++R+ S   + + T +
Sbjct: 574 SPSPGSRSRSRS-RSRSRSRSRSQSRSYSSADSYSSTRR 611


>gi|154146223 splicing factor, arginine/serine-rich 130 [Homo
           sapiens]
          Length = 805

 Score =  123 bits (309), Expect = 5e-28
 Identities = 173/716 (24%), Positives = 279/716 (38%), Gaps = 80/716 (11%)

Query: 46  PTKPATSRNSVMSPSSSKSTKSTSTKRAPSNRPSSRSRVRSKARTPSRVSTDTRTSKASK 105
           P  P T     + P S  S    S + AP NR        +    P   +         +
Sbjct: 108 PWMPPTPGPMDIVPPSEDSNSQDSGEFAPDNRHIFNQNNHNFGGPPDNFAVGPVNQFDYQ 167

Query: 106 ASDVRCHQRRGTHSRGRTPG----------RRGSRSSKRSPSRASTPGRIRTHGARPGMA 155
                   + G H     PG          RR   SS R   R+     ++    +    
Sbjct: 168 HGAAFGPPQGGFHPPYWQPGPPGPPAPPQNRRERPSSFRDRQRSPIALPVKQEPPQIDAV 227

Query: 156 SRVRTPTSQQKGSRGKSYGRPRTSNRERSDSQPRNLSKKSYRPP----GGSGIG------ 205
            R   P   ++G       + +   +ER + Q   LSKK  +      GG G        
Sbjct: 228 KRRTLPAWIREGLEKMEREKQKKLEKERMEQQRSQLSKKEKKATEDAEGGDGPRLPQRSK 287

Query: 206 -------RSSELAVTPSTAKC-QTPTGIPSKEKSDNPSPSSSRKVKSYGQMIIPSREKS- 256
                    +E     S+ K  ++P+ +P +E SD   P  + + K Y  M++     + 
Sbjct: 288 FDSDEEEEDTENVEAASSGKVTRSPSPVPQEEHSD---PEMTEEEKEYQMMLLTKMLLTE 344

Query: 257 ----YSPTEMSSRVKSYNQASTRSRPQSHSQSRSPRRSR---------SGSQKRTHSRVR 303
                +  E+    K  ++ +T++  +  +QS +              SG  +   S   
Sbjct: 345 ILLDVTDEEIYYVAKDAHRKATKAPAKQLAQSSALASLTGLGGLGGYGSGDSEDERSDRG 404

Query: 304 SHSWKRNHSRARSRTR-KGILSQMGRHSQSRSHSKGKSQNQSRTPRRGRSHNW------- 355
           S S   +    R R R K          Q   H K   + + +T R  +  N        
Sbjct: 405 SESSDTDDEELRHRIRQKQEAFWRKEKEQQLLHDKQMEEEKQQTERVTKEMNEFIHKEQN 464

Query: 356 SRNPSKERSHSHSRSSSKERDHRGSSS---PRKE------SGRSQSGSPNKQRDHSRSRS 406
           S +  + R       + K+R    ++S   P+KE       GRS+SGS +     S SR+
Sbjct: 465 SLSLLEAREADGDVVNEKKRTPNETTSVLEPKKEHKEKEKQGRSRSGSSSSGSSSSNSRT 524

Query: 407 PNKARDRSRSRSPYKARDRSRSRSPNKARDCSRSRSPYKARDRSRSRSPNKARDHSRSRS 466
            + +   S S         S S S   +R  SRS SP + +  SRSRSP      SRSRS
Sbjct: 525 SSTSSTVSSS---------SYSSSSGSSRTSSRSSSPKRKKRHSRSRSPTIKARRSRSRS 575

Query: 467 PNKARDRSRSRSPSKERDHSQLGSPSKERDHRRSRSPSKERQCRQSRSSSKER-DHRRSR 525
            ++      +R+  K RD  +    S ER+ RR+RSPS+ER  R+SRS S++R  +R SR
Sbjct: 576 YSRRIKIESNRARVKIRDRRRSNRNSIERERRRNRSPSRER--RRSRSRSRDRRTNRASR 633

Query: 526 SPSKERQRRQSRSPNKERDRSQSRSPSEEREHRQSRSPSKERDRRRWRSPSKERERRQ-S 584
           S S++R++   +  N   +  + +  ++E+E ++ RS S ++DR++     KERER Q  
Sbjct: 634 SRSRDRRKIDDQRGNLSGNSHKHKGEAKEQERKKERSRSIDKDRKK---KDKEREREQDK 690

Query: 585 RSSSEERDHSRSRSPNKQSGYSRPRASSKEKAHSRSRTPSKEGNHSQSRTSSKESDPSQS 644
           R   ++R+    +  ++     R R S  E+  SRS + S +     SR  SK+S    S
Sbjct: 691 RKEKQKREEKDFKFSSQDDRLKRKRES--ERTFSRSGSISVKIIRHDSRQDSKKSTTKDS 748

Query: 645 TVPRSPDWKRSPTRTSSLSQNRTPSKTSSHSPSTFPSGGQTLSQDDSQADATTSKA 700
                 D     +  S  S     +K   HS S      Q   +  S+   + S++
Sbjct: 749 KKHSGSDSSGRSSSESPGSSKEKKAKKPKHSRSRSVEKSQRSGKKASRKHKSKSRS 804



 Score =  115 bits (287), Expect = 2e-25
 Identities = 101/349 (28%), Positives = 165/349 (47%), Gaps = 34/349 (9%)

Query: 278 PQSHSQSRSPRRSRSGSQKRTHSRVRSHSWKRNHSRARSRTRKGILSQMGRHSQSRSHSK 337
           P   +    P++     +K+  SR  S S   + S +R+ +    +S     S S S S 
Sbjct: 486 PNETTSVLEPKKEHKEKEKQGRSRSGSSSSGSSSSNSRTSSTSSTVS-----SSSYSSSS 540

Query: 338 GKSQNQSRT--PRRGRSHNWSRNPSKERSHSHSRSSSKERDHRGSSSPRKESGRSQSGSP 395
           G S+  SR+  P+R + H+ SR+P+ +   S SRS S+      + +  K   R +S   
Sbjct: 541 GSSRTSSRSSSPKRKKRHSRSRSPTIKARRSRSRSYSRRIKIESNRARVKIRDRRRSNRN 600

Query: 396 NKQRDHSRSRSPNKARDRSRSRSPYKARDRSRSRSPNKARDCSRSRSPYKARDRSRSRSP 455
           + +R+  R+RSP++ R RSRSRS    RDR  +R+       SRSR   K  D+  + S 
Sbjct: 601 SIERERRRNRSPSRERRRSRSRS----RDRRTNRASR-----SRSRDRRKIDDQRGNLSG 651

Query: 456 NKARDHSRSRSPNKARDRSRSRSPSKERDHSQLGSPSKERDHRRSRSPSKERQCRQSRS- 514
           N  +    ++   + ++RSRS    +++         K+++  R +   KE+Q R+ +  
Sbjct: 652 NSHKHKGEAKEQERKKERSRSIDKDRKK---------KDKEREREQDKRKEKQKREEKDF 702

Query: 515 SSKERDHRRSRSPSKERQRRQSRSPNKERDRSQSRSPSEEREHRQSR--SPSKERDRRRW 572
               +D R  R    ER   +S S + +  R  SR  S++   + S+  S S    R   
Sbjct: 703 KFSSQDDRLKRKRESERTFSRSGSISVKIIRHDSRQDSKKSTTKDSKKHSGSDSSGRSSS 762

Query: 573 RSPSKERERRQSRSSSEERDHSRSRSPNKQSGYSRPRASSKEKAHSRSR 621
            SP   +E++     +++  HSRSRS  K S  S  +AS K K+ SRSR
Sbjct: 763 ESPGSSKEKK-----AKKPKHSRSRSVEK-SQRSGKKASRKHKSKSRSR 805



 Score = 95.5 bits (236), Expect = 2e-19
 Identities = 101/340 (29%), Positives = 151/340 (44%), Gaps = 45/340 (13%)

Query: 226 PSKEKSDNPSPSSSRK-VKSYGQMIIPSREKSYSPTEMSSRVKSYNQASTRSRPQSHSQS 284
           P KE  +      SR    S G     SR  S S T  SS   SY+ +S  SR  + S+S
Sbjct: 495 PKKEHKEKEKQGRSRSGSSSSGSSSSNSRTSSTSSTVSSS---SYSSSSGSSR--TSSRS 549

Query: 285 RSPRRSRSGSQKRTHSRVRSHSWKRNHSRARSRTRKGILSQMGRHSQSRSHSKGKSQNQS 344
            SP+R      K+ HSR RS + K   SR+RS +R+  +       + R   +    +  
Sbjct: 550 SSPKR------KKRHSRSRSPTIKARRSRSRSYSRRIKIESNRARVKIRDRRRSNRNSIE 603

Query: 345 RTPRRGRSHNWSRNPSKERSHSHSRSSSKERDHRGSSSPRKESGR------SQSGSPNKQ 398
           R  RR RS      PS+ER  S SRS  + R +R S S  ++  +      + SG+ +K 
Sbjct: 604 RERRRNRS------PSRERRRSRSRSRDR-RTNRASRSRSRDRRKIDDQRGNLSGNSHKH 656

Query: 399 RDHSRSRSPNKARDRSRSRSPYKARDRSRSRSPNKARDCSRSRS---PYKARDRSRSRSP 455
           +  ++ +   K R RS  +   K +D+ R R  +K ++  +       + ++D    R  
Sbjct: 657 KGEAKEQERKKERSRSIDKD-RKKKDKEREREQDKRKEKQKREEKDFKFSSQDDRLKRKR 715

Query: 456 NKARDHSRSRSPNKARDRSRSRSPSKE------RDHSQLGSPSKERDHRRSRSPSKERQC 509
              R  SRS S +    R  SR  SK+      + HS  GS S  R    S   SKE++ 
Sbjct: 716 ESERTFSRSGSISVKIIRHDSRQDSKKSTTKDSKKHS--GSDSSGRSSSESPGSSKEKK- 772

Query: 510 RQSRSSSKERDHRRSRSPSKERQRRQSRSPNKERDRSQSR 549
                 +K+  H RSRS  K  QR   ++  K + +S+SR
Sbjct: 773 ------AKKPKHSRSRSVEKS-QRSGKKASRKHKSKSRSR 805



 Score = 87.8 bits (216), Expect = 3e-17
 Identities = 92/339 (27%), Positives = 143/339 (42%), Gaps = 21/339 (6%)

Query: 175 RPRTSNRERSDSQPRNLSKKSYRP----PGGSGIGRSSELAVTPSTAKCQTPTGIPSKEK 230
           + RT N   S  +P+   K+  +      G S  G SS  + T ST+   + +   S   
Sbjct: 482 KKRTPNETTSVLEPKKEHKEKEKQGRSRSGSSSSGSSSSNSRTSSTSSTVSSSSYSSSSG 541

Query: 231 SDNPSPSSSRKVKSYGQMIIPSREKSYSPTEMSSRVKSYNQASTRSRPQSHSQSRSPRRS 290
           S   S  SS   +        SR +S +     SR +SY++       ++  + R  RRS
Sbjct: 542 SSRTSSRSSSPKRKKRH----SRSRSPTIKARRSRSRSYSRRIKIESNRARVKIRDRRRS 597

Query: 291 RSGSQKRTHSRVRSHSWKRNHSRARSRTRKGILSQMGRHSQSRSHSKGKSQNQSRTPRRG 350
              S +R   R RS S +R  SR+RSR R+       R S+SRS  + K  +Q R    G
Sbjct: 598 NRNSIERERRRNRSPSRERRRSRSRSRDRR-----TNRASRSRSRDRRKIDDQ-RGNLSG 651

Query: 351 RSHNWSRNPSKERSHSHSRSSSKERDHRGSSSPRKESGRSQSGSPNKQRDHSRSRSPNKA 410
            SH   +  +KE+     RS S ++D +      KE  R Q     KQ+   +    +  
Sbjct: 652 NSHK-HKGEAKEQERKKERSRSIDKDRKKKD---KEREREQDKRKEKQKREEKDFKFSSQ 707

Query: 411 RDR-SRSRSPYKARDRSRSRSPNKARDCSRSRSPYKARDRSRSRSPNKARDHSRSRSPNK 469
            DR  R R   +   RS S S    R  SR  S       S+  S + +   S S SP  
Sbjct: 708 DDRLKRKRESERTFSRSGSISVKIIRHDSRQDSKKSTTKDSKKHSGSDSSGRSSSESPGS 767

Query: 470 ARDRSRSRSPSKERDHS-QLGSPSKERDHRRSRSPSKER 507
           ++++ +++ P   R  S +    S ++  R+ +S S+ R
Sbjct: 768 SKEK-KAKKPKHSRSRSVEKSQRSGKKASRKHKSKSRSR 805



 Score = 72.8 bits (177), Expect = 1e-12
 Identities = 93/361 (25%), Positives = 140/361 (38%), Gaps = 42/361 (11%)

Query: 36  KSATPNRSLVPTKPATSRNSVMSPSSSKSTKSTSTKRAPSNRPSSRSRVRSKARTPSRVS 95
           K  TPN +    +P            S+S  S+S   + ++R SS S   S +   S  S
Sbjct: 482 KKRTPNETTSVLEPKKEHKEKEKQGRSRSGSSSSGSSSSNSRTSSTSSTVSSSSYSSS-S 540

Query: 96  TDTRTSKASKASDVRCHQRRGTHSRGRTPGRRGSRSSKRSPSRASTPGRIRTHGARPGMA 155
             +RTS  S +      +R+  HSR R+P  +  RS  RS SR     RI+        +
Sbjct: 541 GSSRTSSRSSSP-----KRKKRHSRSRSPTIKARRSRSRSYSR-----RIKIE------S 584

Query: 156 SRVRTPTSQQKGSRGKSYGRPRTSNRERSDSQPRNLSKKSYRPPGGSGIGRSSELAVTPS 215
           +R R     ++ S   S  R R  NR  S  + R+ S+   R    +   RS +      
Sbjct: 585 NRARVKIRDRRRSNRNSIERERRRNRSPSRERRRSRSRSRDRRTNRASRSRSRD------ 638

Query: 216 TAKCQTPTGIPSKEKSDNPSPSSSRKVKSYGQMIIPSREKSYSPTEMSSRVKSYNQASTR 275
                       ++  D     S    K  G+     R+K  S +    R K   +    
Sbjct: 639 -----------RRKIDDQRGNLSGNSHKHKGEAKEQERKKERSRSIDKDRKKKDKERERE 687

Query: 276 SRPQSHSQSRSPRRSRSGSQKRTHSRVRSHSWKRNHSRARSRTRKGILSQMGRHSQSRSH 335
              +   Q R  +  +  SQ     R R    +R  SR+ S + K I+    R    +S 
Sbjct: 688 QDKRKEKQKREEKDFKFSSQDDRLKRKRES--ERTFSRSGSISVK-IIRHDSRQDSKKST 744

Query: 336 SKGKSQNQSRTPRRGRSHNWSRNPSKE---RSHSHSRSSSKERDHR-GSSSPRKESGRSQ 391
           +K  S+  S +   GRS + S   SKE   +   HSRS S E+  R G  + RK   +S+
Sbjct: 745 TK-DSKKHSGSDSSGRSSSESPGSSKEKKAKKPKHSRSRSVEKSQRSGKKASRKHKSKSR 803

Query: 392 S 392
           S
Sbjct: 804 S 804


>gi|154146193 splicing factor, arginine/serine-rich 130 [Homo
           sapiens]
          Length = 805

 Score =  123 bits (309), Expect = 5e-28
 Identities = 173/716 (24%), Positives = 279/716 (38%), Gaps = 80/716 (11%)

Query: 46  PTKPATSRNSVMSPSSSKSTKSTSTKRAPSNRPSSRSRVRSKARTPSRVSTDTRTSKASK 105
           P  P T     + P S  S    S + AP NR        +    P   +         +
Sbjct: 108 PWMPPTPGPMDIVPPSEDSNSQDSGEFAPDNRHIFNQNNHNFGGPPDNFAVGPVNQFDYQ 167

Query: 106 ASDVRCHQRRGTHSRGRTPG----------RRGSRSSKRSPSRASTPGRIRTHGARPGMA 155
                   + G H     PG          RR   SS R   R+     ++    +    
Sbjct: 168 HGAAFGPPQGGFHPPYWQPGPPGPPAPPQNRRERPSSFRDRQRSPIALPVKQEPPQIDAV 227

Query: 156 SRVRTPTSQQKGSRGKSYGRPRTSNRERSDSQPRNLSKKSYRPP----GGSGIG------ 205
            R   P   ++G       + +   +ER + Q   LSKK  +      GG G        
Sbjct: 228 KRRTLPAWIREGLEKMEREKQKKLEKERMEQQRSQLSKKEKKATEDAEGGDGPRLPQRSK 287

Query: 206 -------RSSELAVTPSTAKC-QTPTGIPSKEKSDNPSPSSSRKVKSYGQMIIPSREKS- 256
                    +E     S+ K  ++P+ +P +E SD   P  + + K Y  M++     + 
Sbjct: 288 FDSDEEEEDTENVEAASSGKVTRSPSPVPQEEHSD---PEMTEEEKEYQMMLLTKMLLTE 344

Query: 257 ----YSPTEMSSRVKSYNQASTRSRPQSHSQSRSPRRSR---------SGSQKRTHSRVR 303
                +  E+    K  ++ +T++  +  +QS +              SG  +   S   
Sbjct: 345 ILLDVTDEEIYYVAKDAHRKATKAPAKQLAQSSALASLTGLGGLGGYGSGDSEDERSDRG 404

Query: 304 SHSWKRNHSRARSRTR-KGILSQMGRHSQSRSHSKGKSQNQSRTPRRGRSHNW------- 355
           S S   +    R R R K          Q   H K   + + +T R  +  N        
Sbjct: 405 SESSDTDDEELRHRIRQKQEAFWRKEKEQQLLHDKQMEEEKQQTERVTKEMNEFIHKEQN 464

Query: 356 SRNPSKERSHSHSRSSSKERDHRGSSS---PRKE------SGRSQSGSPNKQRDHSRSRS 406
           S +  + R       + K+R    ++S   P+KE       GRS+SGS +     S SR+
Sbjct: 465 SLSLLEAREADGDVVNEKKRTPNETTSVLEPKKEHKEKEKQGRSRSGSSSSGSSSSNSRT 524

Query: 407 PNKARDRSRSRSPYKARDRSRSRSPNKARDCSRSRSPYKARDRSRSRSPNKARDHSRSRS 466
            + +   S S         S S S   +R  SRS SP + +  SRSRSP      SRSRS
Sbjct: 525 SSTSSTVSSS---------SYSSSSGSSRTSSRSSSPKRKKRHSRSRSPTIKARRSRSRS 575

Query: 467 PNKARDRSRSRSPSKERDHSQLGSPSKERDHRRSRSPSKERQCRQSRSSSKER-DHRRSR 525
            ++      +R+  K RD  +    S ER+ RR+RSPS+ER  R+SRS S++R  +R SR
Sbjct: 576 YSRRIKIESNRARVKIRDRRRSNRNSIERERRRNRSPSRER--RRSRSRSRDRRTNRASR 633

Query: 526 SPSKERQRRQSRSPNKERDRSQSRSPSEEREHRQSRSPSKERDRRRWRSPSKERERRQ-S 584
           S S++R++   +  N   +  + +  ++E+E ++ RS S ++DR++     KERER Q  
Sbjct: 634 SRSRDRRKIDDQRGNLSGNSHKHKGEAKEQERKKERSRSIDKDRKK---KDKEREREQDK 690

Query: 585 RSSSEERDHSRSRSPNKQSGYSRPRASSKEKAHSRSRTPSKEGNHSQSRTSSKESDPSQS 644
           R   ++R+    +  ++     R R S  E+  SRS + S +     SR  SK+S    S
Sbjct: 691 RKEKQKREEKDFKFSSQDDRLKRKRES--ERTFSRSGSISVKIIRHDSRQDSKKSTTKDS 748

Query: 645 TVPRSPDWKRSPTRTSSLSQNRTPSKTSSHSPSTFPSGGQTLSQDDSQADATTSKA 700
                 D     +  S  S     +K   HS S      Q   +  S+   + S++
Sbjct: 749 KKHSGSDSSGRSSSESPGSSKEKKAKKPKHSRSRSVEKSQRSGKKASRKHKSKSRS 804



 Score =  115 bits (287), Expect = 2e-25
 Identities = 101/349 (28%), Positives = 165/349 (47%), Gaps = 34/349 (9%)

Query: 278 PQSHSQSRSPRRSRSGSQKRTHSRVRSHSWKRNHSRARSRTRKGILSQMGRHSQSRSHSK 337
           P   +    P++     +K+  SR  S S   + S +R+ +    +S     S S S S 
Sbjct: 486 PNETTSVLEPKKEHKEKEKQGRSRSGSSSSGSSSSNSRTSSTSSTVS-----SSSYSSSS 540

Query: 338 GKSQNQSRT--PRRGRSHNWSRNPSKERSHSHSRSSSKERDHRGSSSPRKESGRSQSGSP 395
           G S+  SR+  P+R + H+ SR+P+ +   S SRS S+      + +  K   R +S   
Sbjct: 541 GSSRTSSRSSSPKRKKRHSRSRSPTIKARRSRSRSYSRRIKIESNRARVKIRDRRRSNRN 600

Query: 396 NKQRDHSRSRSPNKARDRSRSRSPYKARDRSRSRSPNKARDCSRSRSPYKARDRSRSRSP 455
           + +R+  R+RSP++ R RSRSRS    RDR  +R+       SRSR   K  D+  + S 
Sbjct: 601 SIERERRRNRSPSRERRRSRSRS----RDRRTNRASR-----SRSRDRRKIDDQRGNLSG 651

Query: 456 NKARDHSRSRSPNKARDRSRSRSPSKERDHSQLGSPSKERDHRRSRSPSKERQCRQSRS- 514
           N  +    ++   + ++RSRS    +++         K+++  R +   KE+Q R+ +  
Sbjct: 652 NSHKHKGEAKEQERKKERSRSIDKDRKK---------KDKEREREQDKRKEKQKREEKDF 702

Query: 515 SSKERDHRRSRSPSKERQRRQSRSPNKERDRSQSRSPSEEREHRQSR--SPSKERDRRRW 572
               +D R  R    ER   +S S + +  R  SR  S++   + S+  S S    R   
Sbjct: 703 KFSSQDDRLKRKRESERTFSRSGSISVKIIRHDSRQDSKKSTTKDSKKHSGSDSSGRSSS 762

Query: 573 RSPSKERERRQSRSSSEERDHSRSRSPNKQSGYSRPRASSKEKAHSRSR 621
            SP   +E++     +++  HSRSRS  K S  S  +AS K K+ SRSR
Sbjct: 763 ESPGSSKEKK-----AKKPKHSRSRSVEK-SQRSGKKASRKHKSKSRSR 805



 Score = 95.5 bits (236), Expect = 2e-19
 Identities = 101/340 (29%), Positives = 151/340 (44%), Gaps = 45/340 (13%)

Query: 226 PSKEKSDNPSPSSSRK-VKSYGQMIIPSREKSYSPTEMSSRVKSYNQASTRSRPQSHSQS 284
           P KE  +      SR    S G     SR  S S T  SS   SY+ +S  SR  + S+S
Sbjct: 495 PKKEHKEKEKQGRSRSGSSSSGSSSSNSRTSSTSSTVSSS---SYSSSSGSSR--TSSRS 549

Query: 285 RSPRRSRSGSQKRTHSRVRSHSWKRNHSRARSRTRKGILSQMGRHSQSRSHSKGKSQNQS 344
            SP+R      K+ HSR RS + K   SR+RS +R+  +       + R   +    +  
Sbjct: 550 SSPKR------KKRHSRSRSPTIKARRSRSRSYSRRIKIESNRARVKIRDRRRSNRNSIE 603

Query: 345 RTPRRGRSHNWSRNPSKERSHSHSRSSSKERDHRGSSSPRKESGR------SQSGSPNKQ 398
           R  RR RS      PS+ER  S SRS  + R +R S S  ++  +      + SG+ +K 
Sbjct: 604 RERRRNRS------PSRERRRSRSRSRDR-RTNRASRSRSRDRRKIDDQRGNLSGNSHKH 656

Query: 399 RDHSRSRSPNKARDRSRSRSPYKARDRSRSRSPNKARDCSRSRS---PYKARDRSRSRSP 455
           +  ++ +   K R RS  +   K +D+ R R  +K ++  +       + ++D    R  
Sbjct: 657 KGEAKEQERKKERSRSIDKD-RKKKDKEREREQDKRKEKQKREEKDFKFSSQDDRLKRKR 715

Query: 456 NKARDHSRSRSPNKARDRSRSRSPSKE------RDHSQLGSPSKERDHRRSRSPSKERQC 509
              R  SRS S +    R  SR  SK+      + HS  GS S  R    S   SKE++ 
Sbjct: 716 ESERTFSRSGSISVKIIRHDSRQDSKKSTTKDSKKHS--GSDSSGRSSSESPGSSKEKK- 772

Query: 510 RQSRSSSKERDHRRSRSPSKERQRRQSRSPNKERDRSQSR 549
                 +K+  H RSRS  K  QR   ++  K + +S+SR
Sbjct: 773 ------AKKPKHSRSRSVEKS-QRSGKKASRKHKSKSRSR 805



 Score = 87.8 bits (216), Expect = 3e-17
 Identities = 92/339 (27%), Positives = 143/339 (42%), Gaps = 21/339 (6%)

Query: 175 RPRTSNRERSDSQPRNLSKKSYRP----PGGSGIGRSSELAVTPSTAKCQTPTGIPSKEK 230
           + RT N   S  +P+   K+  +      G S  G SS  + T ST+   + +   S   
Sbjct: 482 KKRTPNETTSVLEPKKEHKEKEKQGRSRSGSSSSGSSSSNSRTSSTSSTVSSSSYSSSSG 541

Query: 231 SDNPSPSSSRKVKSYGQMIIPSREKSYSPTEMSSRVKSYNQASTRSRPQSHSQSRSPRRS 290
           S   S  SS   +        SR +S +     SR +SY++       ++  + R  RRS
Sbjct: 542 SSRTSSRSSSPKRKKRH----SRSRSPTIKARRSRSRSYSRRIKIESNRARVKIRDRRRS 597

Query: 291 RSGSQKRTHSRVRSHSWKRNHSRARSRTRKGILSQMGRHSQSRSHSKGKSQNQSRTPRRG 350
              S +R   R RS S +R  SR+RSR R+       R S+SRS  + K  +Q R    G
Sbjct: 598 NRNSIERERRRNRSPSRERRRSRSRSRDRR-----TNRASRSRSRDRRKIDDQ-RGNLSG 651

Query: 351 RSHNWSRNPSKERSHSHSRSSSKERDHRGSSSPRKESGRSQSGSPNKQRDHSRSRSPNKA 410
            SH   +  +KE+     RS S ++D +      KE  R Q     KQ+   +    +  
Sbjct: 652 NSHK-HKGEAKEQERKKERSRSIDKDRKKKD---KEREREQDKRKEKQKREEKDFKFSSQ 707

Query: 411 RDR-SRSRSPYKARDRSRSRSPNKARDCSRSRSPYKARDRSRSRSPNKARDHSRSRSPNK 469
            DR  R R   +   RS S S    R  SR  S       S+  S + +   S S SP  
Sbjct: 708 DDRLKRKRESERTFSRSGSISVKIIRHDSRQDSKKSTTKDSKKHSGSDSSGRSSSESPGS 767

Query: 470 ARDRSRSRSPSKERDHS-QLGSPSKERDHRRSRSPSKER 507
           ++++ +++ P   R  S +    S ++  R+ +S S+ R
Sbjct: 768 SKEK-KAKKPKHSRSRSVEKSQRSGKKASRKHKSKSRSR 805



 Score = 72.8 bits (177), Expect = 1e-12
 Identities = 93/361 (25%), Positives = 140/361 (38%), Gaps = 42/361 (11%)

Query: 36  KSATPNRSLVPTKPATSRNSVMSPSSSKSTKSTSTKRAPSNRPSSRSRVRSKARTPSRVS 95
           K  TPN +    +P            S+S  S+S   + ++R SS S   S +   S  S
Sbjct: 482 KKRTPNETTSVLEPKKEHKEKEKQGRSRSGSSSSGSSSSNSRTSSTSSTVSSSSYSSS-S 540

Query: 96  TDTRTSKASKASDVRCHQRRGTHSRGRTPGRRGSRSSKRSPSRASTPGRIRTHGARPGMA 155
             +RTS  S +      +R+  HSR R+P  +  RS  RS SR     RI+        +
Sbjct: 541 GSSRTSSRSSSP-----KRKKRHSRSRSPTIKARRSRSRSYSR-----RIKIE------S 584

Query: 156 SRVRTPTSQQKGSRGKSYGRPRTSNRERSDSQPRNLSKKSYRPPGGSGIGRSSELAVTPS 215
           +R R     ++ S   S  R R  NR  S  + R+ S+   R    +   RS +      
Sbjct: 585 NRARVKIRDRRRSNRNSIERERRRNRSPSRERRRSRSRSRDRRTNRASRSRSRD------ 638

Query: 216 TAKCQTPTGIPSKEKSDNPSPSSSRKVKSYGQMIIPSREKSYSPTEMSSRVKSYNQASTR 275
                       ++  D     S    K  G+     R+K  S +    R K   +    
Sbjct: 639 -----------RRKIDDQRGNLSGNSHKHKGEAKEQERKKERSRSIDKDRKKKDKERERE 687

Query: 276 SRPQSHSQSRSPRRSRSGSQKRTHSRVRSHSWKRNHSRARSRTRKGILSQMGRHSQSRSH 335
              +   Q R  +  +  SQ     R R    +R  SR+ S + K I+    R    +S 
Sbjct: 688 QDKRKEKQKREEKDFKFSSQDDRLKRKRES--ERTFSRSGSISVK-IIRHDSRQDSKKST 744

Query: 336 SKGKSQNQSRTPRRGRSHNWSRNPSKE---RSHSHSRSSSKERDHR-GSSSPRKESGRSQ 391
           +K  S+  S +   GRS + S   SKE   +   HSRS S E+  R G  + RK   +S+
Sbjct: 745 TK-DSKKHSGSDSSGRSSSESPGSSKEKKAKKPKHSRSRSVEKSQRSGKKASRKHKSKSR 803

Query: 392 S 392
           S
Sbjct: 804 S 804


>gi|158854042 hypothetical protein LOC222183 [Homo sapiens]
          Length = 653

 Score =  120 bits (300), Expect = 6e-27
 Identities = 148/521 (28%), Positives = 204/521 (39%), Gaps = 55/521 (10%)

Query: 62  SKSTKSTSTKRAPSNRPSSRSRVRSKARTPSRVSTDTRTSKASKASDVRCHQRRGTHSRG 121
           S S+ S   K+    +   R R R K R  S  S  + +    K   V+ H+R  + S  
Sbjct: 160 SSSSASPPPKKKKKKKGGHR-RSRKKRRLESECSCGSSSPLRKKKKSVKKHRRDRSDSGS 218

Query: 122 RTPGRRGSRSSK---------RSPSRASTPGRIRTHGARPGMASRVRTPTSQQKGSRGKS 172
           R   R  SRSSK         +      +PGR R+H    G +S   + +S    SR  S
Sbjct: 219 RRKRRHRSRSSKCKRKEKNKEKKRPHTESPGR-RSHRHSSG-SSHSPSLSSHYSDSRSPS 276

Query: 173 YGRPRTSNRERSDSQPRNLSKKSYRPPGGSGIGRSSELAVTPSTAKCQTPTGIPSKEKSD 232
              P+  +  R     R+   +S  P GGSG G       +   +         +    D
Sbjct: 277 RLSPKHRDEGRKTGSQRSSGSRSPSPSGGSGWGSPQRNGGSGQRSGAHGGRPGSAHSPPD 336

Query: 233 NPSPSSSRKVKSYGQMIIPSREKSYSPTEMSSRVKSYNQASTRSRPQSHSQSRSPRRSRS 292
            PS  S R         +  +  + +PT  +   +     S RS P S  +     R+  
Sbjct: 337 KPSSPSPR---------VRDKAAAAAPTPPA---RGKESPSPRSAPSSQGRG---GRAAG 381

Query: 293 GSQKRTHSRVRSHSWKRNHSRARSRTRKGILSQMGRHSQSRSHSKGKSQNQSRTPRRGRS 352
           G+ +R   R R    + + S  R R R+       R S SRS S+ +S + S + R    
Sbjct: 382 GAGRRRRRRRRRRRSRSSASAPRRRGRRRPRPAPPRGS-SRSLSRARSSSDSGSGRGAPG 440

Query: 353 HNWSRNPSKERSHSHSRSSSKERDHR---GSSSPRKESGRSQSGSPNKQRDHSRSRSPN- 408
                 P  ER H      +KER  R    S+SP   +   + G   K    S SRSP  
Sbjct: 441 P--GPEPGSERGHGGHGKRAKERPPRARPASTSPSPGAHGRRGGPEGK----SSSRSPGP 494

Query: 409 KARDRSRSRSPYKARDRSRSRSPNKARDCSRSRSPYKARDRSRSRSPNKARDHSRSRSPN 468
             R  S SRSP K+R RS  + P+     S SRSP   +  SR +       HS + +  
Sbjct: 495 HPRSWSSSRSPSKSRSRSAEKRPH-----SPSRSPSPKKPLSRDKDGEGRARHSEAEA-T 548

Query: 469 KARDRSRSRSP--SKERDHSQLGSPSKERDHRR------SRSPSKERQCRQSRSSSKERD 520
           +AR RSRS SP   + RD      P +    R+        SPS    C  S  S+  R 
Sbjct: 549 RARRRSRSYSPIRKRRRDSPSFMEPRRITSARKRPIPYYRPSPSSSSSCLSSDYST--RS 606

Query: 521 HRRSRSPSKERQRRQSRS-PNKERDRSQSRSPSEEREHRQS 560
           H RS SP        SRS   + R RS SR+PS     R S
Sbjct: 607 HSRSPSPGHSHGSYSSRSHGTRSRTRSPSRTPSPSYHSRSS 647



 Score =  119 bits (298), Expect = 1e-26
 Identities = 148/509 (29%), Positives = 204/509 (40%), Gaps = 74/509 (14%)

Query: 256 SYSPTEMSSRVKSYNQASTRSRPQSHSQ----SRSPRRSRSGSQKRTHSRVRSHSWKRNH 311
           S SP     + K      +R + +  S+    S SP R +  S K+ H R RS S  R  
Sbjct: 163 SASPPPKKKKKKKGGHRRSRKKRRLESECSCGSSSPLRKKKKSVKK-HRRDRSDSGSRRK 221

Query: 312 SRARSRTRKGILSQMGRHSQSRSHSKGKSQNQSRTPRRGRSHNWSRNPSKERSHSHSRSS 371
            R RSR+ K    +  +  + R H++   +   R    G SH+ S +     S S SR S
Sbjct: 222 RRHRSRSSKCKRKEKNKEKK-RPHTESPGRRSHRHSS-GSSHSPSLSSHYSDSRSPSRLS 279

Query: 372 SKERDH-RGSSSPRKESGRSQS-------GSPNK-----QRDHSRSRSPNKAR---DRSR 415
            K RD  R + S R    RS S       GSP +     QR  +    P  A    D+  
Sbjct: 280 PKHRDEGRKTGSQRSSGSRSPSPSGGSGWGSPQRNGGSGQRSGAHGGRPGSAHSPPDKPS 339

Query: 416 SRSPYKARDRSRSRSPNKARDCSRSRSPYKARDRSRSRSPNKARDHSRSRSPNKARDRSR 475
           S SP + RD++ + +P        S SP  A   S+ R    A    R R   + R RSR
Sbjct: 340 SPSP-RVRDKAAAAAPTPPARGKESPSPRSAPS-SQGRGGRAAGGAGRRRRRRRRRRRSR 397

Query: 476 SRSPSKERDHSQLGSPSKERDHRRSRSPSKERQCRQSRSSSKERDHRRSRSPSKER---- 531
           S + +  R   +   P+  R   RS S        ++RSSS     R +  P  E     
Sbjct: 398 SSASAPRRRGRRRPRPAPPRGSSRSLS--------RARSSSDSGSGRGAPGPGPEPGSER 449

Query: 532 ------QRRQSRSPNKERDRSQSRSPSEEREHRQSRSPSKERDR------RRW---RSPS 576
                 +R + R P   R R  S SPS     R+     K   R      R W   RSPS
Sbjct: 450 GHGGHGKRAKERPP---RARPASTSPSPGAHGRRGGPEGKSSSRSPGPHPRSWSSSRSPS 506

Query: 577 KERERRQSRSSSEERDHSRSRSPNKQS-------GYSRPRASSKEKAHSRSRTPSKEGNH 629
           K R R     S+E+R HS SRSP+ +        G  R R S  E   +R R+ S     
Sbjct: 507 KSRSR-----SAEKRPHSPSRSPSPKKPLSRDKDGEGRARHSEAEATRARRRSRSYSPIR 561

Query: 630 SQSRTSSKESDPSQSTVPRS---PDWKRSPTRTSSLSQNRTPSKTSSHSPSTFPSGGQTL 686
            + R S    +P + T  R    P ++ SP+ +SS   +   +++ S SPS   S G   
Sbjct: 562 KRRRDSPSFMEPRRITSARKRPIPYYRPSPSSSSSCLSSDYSTRSHSRSPSPGHSHGSYS 621

Query: 687 SQDDSQADATTSKATLPG----ERSSSSS 711
           S+       T S +  P      RSSS S
Sbjct: 622 SRSHGTRSRTRSPSRTPSPSYHSRSSSES 650



 Score = 98.2 bits (243), Expect = 2e-20
 Identities = 133/504 (26%), Positives = 194/504 (38%), Gaps = 67/504 (13%)

Query: 254 EKSYSPTEMSSRVKSYNQA--------STRSRPQSHSQSRSPRRSRSGSQKRTHSRVRSH 305
           E+ YS  E+  +V ++ Q         +   RP  H  + +PR +        ++     
Sbjct: 76  EQGYSEEEIRQKVGTFRQMLMEKEGVLTREDRPGGHIVAETPRLTEGAEPGLEYAPFDDD 135

Query: 306 SWKRNHSRARSRTRKGILSQMGRHSQSRSHSKGKSQNQSRTPRRGRSHNWSRNPSKERSH 365
               +     S  R       G  ++  S S      + +  ++G  H  SR   +  S 
Sbjct: 136 DGPVDCDCPASCYR----GHRGYRTKHWSSSSASPPPKKKKKKKG-GHRRSRKKRRLESE 190

Query: 366 SHSRSSSKERDHRGSSSPRKESGRSQSGSPNKQRDHSRS-----RSPNKARDRSRSRSPY 420
               SSS  R  + S    +   RS SGS  K+R  SRS     +  NK + R  + SP 
Sbjct: 191 CSCGSSSPLRKKKKSVKKHRRD-RSDSGSRRKRRHRSRSSKCKRKEKNKEKKRPHTESPG 249

Query: 421 KARDRSRSRSPNKARDCSRSRSPYKARDRSRSRSPNKARDHSRSRSPNKARDRSRSRSPS 480
           +   R  S S +     S S S + +  RS SR   K RD  R     ++   S SRSPS
Sbjct: 250 RRSHRHSSGSSH-----SPSLSSHYSDSRSPSRLSPKHRDEGRKTGSQRS---SGSRSPS 301

Query: 481 KERDHSQLGSP-----SKERDHRRSRSPSKERQ--CRQSRSSSKERDHRRSRSPSKERQR 533
                S  GSP     S +R       P        + S  S + RD   + +P+   + 
Sbjct: 302 PS-GGSGWGSPQRNGGSGQRSGAHGGRPGSAHSPPDKPSSPSPRVRDKAAAAAPTPPARG 360

Query: 534 RQSRSPNKERDRSQSRS----------PSEEREHRQSRSPSKERDRRRWRSPSKERERRQ 583
           ++S SP +    SQ R               R  R+SRS +    RR  R P     R  
Sbjct: 361 KESPSP-RSAPSSQGRGGRAAGGAGRRRRRRRRRRRSRSSASAPRRRGRRRPRPAPPRGS 419

Query: 584 SRSSSEERDHSRSRS----------PNKQSGYSRPRASSKE---KAHSRSRTPSKEGNHS 630
           SRS S  R  S S S          P  + G+      +KE   +A   S +PS   +  
Sbjct: 420 SRSLSRARSSSDSGSGRGAPGPGPEPGSERGHGGHGKRAKERPPRARPASTSPSPGAHGR 479

Query: 631 QSRTSSKESDPSQSTVPRSPDWKRSPTRTSSLSQNRTPSKTSSHSPSTFPSGGQTLSQD- 689
           +     K S  S    PRS    RSP+++ S S  + P     HSPS  PS  + LS+D 
Sbjct: 480 RGGPEGKSSSRSPGPHPRSWSSSRSPSKSRSRSAEKRP-----HSPSRSPSPKKPLSRDK 534

Query: 690 --DSQADATTSKATLPGERSSSSS 711
             + +A  + ++AT    RS S S
Sbjct: 535 DGEGRARHSEAEATRARRRSRSYS 558



 Score = 94.0 bits (232), Expect = 4e-19
 Identities = 138/531 (25%), Positives = 189/531 (35%), Gaps = 61/531 (11%)

Query: 23  TADPKPPASLKSTKSATPNRSLVPTKPATSRNSVMSPSSSKSTKSTSTKRAPSNRPSSRS 82
           ++   PP   K  K     RS    K           SS    K  S K+   +R  S S
Sbjct: 161 SSSASPPPKKKKKKKGGHRRSR--KKRRLESECSCGSSSPLRKKKKSVKKHRRDRSDSGS 218

Query: 83  RVRSKARTPSRVSTDTRTSKASKASDVRCHQRRG-THSRG--RTPGRRGSRSSKRSPSRA 139
           R + + R+ S        +K  K        RR   HS G   +P      S  RSPSR 
Sbjct: 219 RRKRRHRSRSSKCKRKEKNKEKKRPHTESPGRRSHRHSSGSSHSPSLSSHYSDSRSPSRL 278

Query: 140 STPGRI--RTHGARPGMASRVRTPTSQQKGSRGKSYGRPRTS--NRERSDS---QPRNLS 192
           S   R   R  G++    SR  +P      S G  +G P+ +  + +RS +   +P +  
Sbjct: 279 SPKHRDEGRKTGSQRSSGSRSPSP------SGGSGWGSPQRNGGSGQRSGAHGGRPGSAH 332

Query: 193 KKSYRPPGGSGIGRSSELAVTPSTAKCQTPTGIPSKEKSDNPSPSSSRKVKSYGQMIIPS 252
               +P   S   R    A  P+          P     ++PSP S+   +  G      
Sbjct: 333 SPPDKPSSPSPRVRDKAAAAAPT----------PPARGKESPSPRSAPSSQGRGGRAAGG 382

Query: 253 REKSYSPTEMSSRVKSYNQASTRSRPQSHSQSRSPRRSRSGSQKRTHSRVRSHSWKRNHS 312
             +               +   R R +S S + +PRR      +    R  S S  R  S
Sbjct: 383 AGR--------------RRRRRRRRRRSRSSASAPRRRGRRRPRPAPPRGSSRSLSRARS 428

Query: 313 RARSRTRKGILSQMGRHSQSRSHSKGKSQNQSRTPRRGRSHNWSRNPSKERSHSHSRSSS 372
            + S + +G           R H  G  +     P R R  + S +P      +H R   
Sbjct: 429 SSDSGSGRGAPGPGPEPGSERGHG-GHGKRAKERPPRARPASTSPSPG-----AHGRRGG 482

Query: 373 KERDHRGSSSPRKESGRSQSGSPNKQRDHSRSRSPNKARDRSRSRSPYKARDRSRSRSPN 432
            E    G SS R      +S S ++    SRSRS  K R  S SRSP   +  SR +   
Sbjct: 483 PE----GKSSSRSPGPHPRSWSSSRSPSKSRSRSAEK-RPHSPSRSPSPKKPLSRDKD-G 536

Query: 433 KARDCSRSRSPYKARDRSRSRSP-NKARDHSRSRSPNKARDRSRSR-----SPSKERDHS 486
           + R         +AR RSRS SP  K R  S S    +    +R R      PS     S
Sbjct: 537 EGRARHSEAEATRARRRSRSYSPIRKRRRDSPSFMEPRRITSARKRPIPYYRPSPSSSSS 596

Query: 487 QLGSPSKERDHRRSRSPSKERQCRQSRS-SSKERDHRRSRSPSKERQRRQS 536
            L S    R H RS SP        SRS  ++ R    SR+PS     R S
Sbjct: 597 CLSSDYSTRSHSRSPSPGHSHGSYSSRSHGTRSRTRSPSRTPSPSYHSRSS 647



 Score = 72.0 bits (175), Expect = 2e-12
 Identities = 109/403 (27%), Positives = 156/403 (38%), Gaps = 47/403 (11%)

Query: 3   SPKRSSKPSMSLAPSGSSMPTADP-KPPASLKSTKSATPNRSLVPTKPATSRNSVMSPSS 61
           SP  SS  S S +PS  S    D  +   S +S+ S +P+ S      +  RN      S
Sbjct: 262 SPSLSSHYSDSRSPSRLSPKHRDEGRKTGSQRSSGSRSPSPSGGSGWGSPQRNGGSGQRS 321

Query: 62  SKSTKSTSTKRAPSNRPSSRS-RVRSKA------------RTPSRVSTDTRTSKASKASD 108
                   +  +P ++PSS S RVR KA             +PS  S  +   +  +A+ 
Sbjct: 322 GAHGGRPGSAHSPPDKPSSPSPRVRDKAAAAAPTPPARGKESPSPRSAPSSQGRGGRAAG 381

Query: 109 V------RCHQRRGTHSRGRTPGRRGSRSSKRSPSRASTPGRIRTHGARPGMASRVRTPT 162
                  R  +RR + S    P RRG R  + +P R S+    R   +    + R     
Sbjct: 382 GAGRRRRRRRRRRRSRSSASAPRRRGRRRPRPAPPRGSSRSLSRARSSSDSGSGRGAPGP 441

Query: 163 SQQKGSRGKSYGRPRTSNRERSDSQPRNLSKKSYRPPGGSGIGRSSELAVTPSTAKCQTP 222
             + GS      R    + +R+  +P      S  P  G+   R       P        
Sbjct: 442 GPEPGSE-----RGHGGHGKRAKERPPRARPASTSPSPGAHGRRGG-----PEGKSSSRS 491

Query: 223 TGIPSKEKSDNPSPSSSRKVKSYGQMIIPSREKSYSPTEMSSRVKSYNQASTRSRPQSHS 282
            G   +  S + SPS SR   +  +   PSR  S SP +  SR K       R+R     
Sbjct: 492 PGPHPRSWSSSRSPSKSRSRSAEKRPHSPSR--SPSPKKPLSRDK---DGEGRARHSEAE 546

Query: 283 QSRSPRRSRSGSQKRTHSR-VRSHSWKRNHSRARSR-------TRKGILSQMGRHSQSRS 334
            +R+ RRSRS S  R   R   S    R  + AR R       +     S +     +RS
Sbjct: 547 ATRARRRSRSYSPIRKRRRDSPSFMEPRRITSARKRPIPYYRPSPSSSSSCLSSDYSTRS 606

Query: 335 HSKGKSQNQSRTPRRGRSH---NWSRNPSKERSHS-HSRSSSK 373
           HS+  S   S      RSH   + +R+PS+  S S HSRSSS+
Sbjct: 607 HSRSPSPGHSHGSYSSRSHGTRSRTRSPSRTPSPSYHSRSSSE 649


>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
          Length = 1020

 Score =  118 bits (295), Expect = 2e-26
 Identities = 104/521 (19%), Positives = 235/521 (45%), Gaps = 48/521 (9%)

Query: 223  TGIPSKEKSDNPSPSSSRKVK----SYGQMIIPSREKSYSPTEMSSRVKSYNQASTRSRP 278
            T  P  E++ +P   +   VK    S  +   P +E++ SP E+ S  K+ + A   ++ 
Sbjct: 501  TKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKS 560

Query: 279  QSHSQSRSPRRSRSGSQKRTHSRVRSHSWKRNHSRARSRTRKGILSQMGRHSQSRSHSKG 338
               ++S     ++S ++ ++  + +S + +   S A +++ +   S +   ++S + +K 
Sbjct: 561  PPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKS 620

Query: 339  KSQNQSRTPRRGRSHNWSRNPSKERSHSHSRSSSKERDHRGSSSPRKESGRSQSGSPNKQ 398
              + ++++P   +S   +++P+KE + S  ++ S E++   S    K   ++++ SP K 
Sbjct: 621  PVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEK- 679

Query: 399  RDHSRSRSPNKARDRSRSRSPYKARD--RSRSRSPNKARDCSRSRSPYKARDRSRSRSPN 456
                 ++SP KA     ++SP KA+   +  ++SP KA+  S  +   K+ ++++S    
Sbjct: 680  -----AKSPVKA----EAKSPEKAKSPVKEEAKSPEKAK--SPVKEEAKSPEKAKSPVKE 728

Query: 457  KARDHSRSRSPNK--ARDRSRSRSPSKERDHSQLGSPSKERDHRRSRSPSKERQCRQSRS 514
            +A+   +++SP K  A+   +++SP K +        +K      +RSP+ ++   +++S
Sbjct: 729  EAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPA-DKFPEKAKS 787

Query: 515  SSKE--RDHRRSRSPSKERQRRQSRS-PNKERDRSQSRSPSEEREHRQSRSPSKERDRRR 571
              KE  +   +++SP KE  +   +  P KE  +S  +   + +E +    P K  + + 
Sbjct: 788  PVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKA 847

Query: 572  WRSPSKERERRQSRSSSEERDHSRSR-SPNKQSGYSRPRAS----SKEKAHSRSRTPSKE 626
              +P  E ++   +  + +++  + +    K+    +P+ S     KE+A  + + P+ E
Sbjct: 848  PATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPE 907

Query: 627  GN-------------HSQSRTSSKESDPSQSTVPRSPDWKRSPTRTSSLSQNRTPSKTSS 673
                             ++  + KE D +++  P  P  K+      +  + +   +  +
Sbjct: 908  KEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKK-----EAAPEKKDTKEEKA 962

Query: 674  HSPSTFPSGGQTLSQDDSQADATTSKATL-PGERSSSSSSK 713
              P   P       +DD       SK      E+SSS+  K
Sbjct: 963  KKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTDQK 1003



 Score =  109 bits (273), Expect = 8e-24
 Identities = 98/498 (19%), Positives = 236/498 (47%), Gaps = 40/498 (8%)

Query: 206  RSSELAVTPSTAKCQTPTGIPSKEKSDNPSPSSSRKVKSYGQMIIPSREKSYSPTEMSSR 265
            +S   A +P   + ++P  + S EK+ +P+     + KS  +   P +E++ SP E+ S 
Sbjct: 525  KSPAEAKSPEKEEAKSPAEVKSPEKAKSPA---KEEAKSPPEAKSPEKEEAKSPAEVKSP 581

Query: 266  VKSYNQASTRSRPQSHSQSRSPRRSRSGSQKRTHSRVRSHSWKRNHSRARSRTRKGILSQ 325
             K+ + A   ++  S ++++SP +++S  ++   S   + S  +  +++ +  +    ++
Sbjct: 582  EKAKSPAKEEAK--SPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAK 639

Query: 326  MGRHSQSRSHSKGKS--QNQSRTPRRGRSHNWSRNPSKERSHSHSRSSSKERDHRGSSSP 383
                 +++S  K KS  + ++++P + +S   +   S E++ S  ++ +K  +   + SP
Sbjct: 640  SPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEK--AKSP 697

Query: 384  RKESGRS--QSGSPNKQRDHS--RSRSPNK--ARDRSRSRSPYK--ARDRSRSRSPNKAR 435
             KE  +S  ++ SP K+   S  +++SP K  A+   +++SP K  A+   +++SP KA+
Sbjct: 698  VKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAK 757

Query: 436  --DCSRSRSPYKARDRSRS---RSPNKARDHSRS--RSPNKARDRSRSRS-------PSK 481
              D     +   A++ +RS   + P KA+   +   +SP KA+   +  +       P K
Sbjct: 758  TLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKK 817

Query: 482  ERDHSQLGSPSKERDHRRSRSPSK--ERQCRQSRSSSKERDHRRSRSPSKERQR---RQS 536
            E   S +    K ++ +    P K  E +   +  + +++D ++  +P KE  +    + 
Sbjct: 818  EEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEK 877

Query: 537  RSPNKERDRSQSRSPSEEREHRQSRSPSKERDR-RRWRSPSKERERRQSRSSSEERDHSR 595
            + P  E+ +       +E    + + P+ E++   +       + + ++  + +E D ++
Sbjct: 878  KEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAK 937

Query: 596  SRSPNKQSGYSRPRASSKEKAHSRSRTPSKEGNHSQSRTSSKESDPSQSTVPRSPDWKRS 655
            ++ P+K    +  + ++ EK  ++     K     ++   +KE D + S  P  P  +++
Sbjct: 938  AKEPSKP---AEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKA 994

Query: 656  PTRTSSLSQNRTPSKTSS 673
               +S+  ++  P + ++
Sbjct: 995  EKSSSTDQKDSKPPEKAT 1012



 Score =  105 bits (263), Expect = 1e-22
 Identities = 97/551 (17%), Positives = 243/551 (44%), Gaps = 51/551 (9%)

Query: 63   KSTKSTSTKRAPSNRPSSRSRVRSKARTPSRVSTDTRTSKASKASDVRCHQRRGTHSRGR 122
            + TKS   + A S    ++S V+ +A++P+   +  +  +A   ++V+  ++       +
Sbjct: 499  EETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEK-EEAKSPAEVKSPEK------AK 551

Query: 123  TPGRRGSRS--SKRSPSR--ASTPGRIRT-HGARPGMASRVRTPTSQQKGSRGKSYGRPR 177
            +P +  ++S    +SP +  A +P  +++   A+       ++P   +   + KS     
Sbjct: 552  SPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKS----P 607

Query: 178  TSNRERSDSQPRNLSKKSYRPPGGSGIGRSSELAVTPSTAKCQTPTGIPSKEKSDNPSPS 237
                 +S ++ ++  K+  + P      +S E A +P+  + ++P    S EK +  SP 
Sbjct: 608  VKEEAKSPAEAKSPVKEEAKSPAEV---KSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPE 664

Query: 238  SSRKVKSYGQMIIPSREKSYSPTEMSSRVKSYNQASTRSRPQSHSQSRSPRRSRSGSQKR 297
             ++          P + ++ SP +  S VK+  ++  +++     +++SP +++S  ++ 
Sbjct: 665  KAKS---------PVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEE 715

Query: 298  THSRVRSHSWKRNHSRARSRTRKGILSQMGRHSQSRSHSKGKSQN----QSRTPRRGRSH 353
              S  ++ S  +  ++   + +  +  +     +++S  K K+ +    +++TP +  + 
Sbjct: 716  AKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEAR 775

Query: 354  NWS-RNPSKERSHSHSRSSSKERDHRGSSSPRKESGRS-QSGSPNKQRDHSRSRSPNKAR 411
            + + + P K +S       S E+    + SP KE  ++ +   P K+   S  +   K +
Sbjct: 776  SPADKFPEKAKSPVKEEVKSPEK----AKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQ 831

Query: 412  DRSRSRSPYKARDRSRSRSPNKARDCSRSRSPYKARDRSRSRSPNKARDHSRSRSPNKAR 471
            +      P KA +     +P      +  +   K  +  +  +P    +  +  +  K +
Sbjct: 832  EVKVKEPPKKAEEEKAPATPK-----TEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPK 886

Query: 472  DRSRSRSPSKERDHSQLGSPSKERDHR-RSRSPSKERQCRQSRSSSKERDHRRSRSPSKE 530
            +        +  D  ++ +P KE   +   +  +K ++  ++  + KE D  +++ PSK 
Sbjct: 887  ESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKE--KTEVAKKEPDDAKAKEPSKP 944

Query: 531  RQRRQSRSPNKERDRSQSRSPSEEREHRQSRSPSKERDRRRWRSPSKERERRQSRSSSEE 590
             +++++    K+    +++ P E+    ++ + +KE D+   + PSK +  +  +SSS  
Sbjct: 945  AEKKEAAPEKKDTKEEKAKKPEEK---PKTEAKAKEDDKTLSKEPSKPKAEKAEKSSS-- 999

Query: 591  RDHSRSRSPNK 601
             D   S+ P K
Sbjct: 1000 TDQKDSKPPEK 1010



 Score =  103 bits (257), Expect = 6e-22
 Identities = 85/444 (19%), Positives = 200/444 (45%), Gaps = 27/444 (6%)

Query: 222 PTGIPSKEKSDNPSPSSSRKVKSYGQMIIPSREKSYSPTEMSSRVKSYNQASTRSRPQSH 281
           P G+P       PS S+  KVKS  ++ +   EKS   T +        Q +     +  
Sbjct: 423 PEGLPKI-----PSVSTHIKVKSEEKIKVV--EKSEKETVIVEEQTEETQVTEEVTEEEE 475

Query: 282 SQSRSPRRSRSGSQKRTHSRVRSHSWKRNHSRARSRTRKGILSQMGRHSQSRSHSKGKSQ 341
            +++          +   +       K   +   +   K   S +   ++S + +K   +
Sbjct: 476 KEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEK 535

Query: 342 NQSRTPRRGRSHNWSRNPSKERSHSHSRSSSKERDHRGSSSPRKESGRSQSGSPNKQRDH 401
            ++++P   +S   +++P+KE + S   + S E++   S +  K   +++S +  + +  
Sbjct: 536 EEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSP 595

Query: 402 SRSRSPNKARD--RSRSRSPYKARD--RSRSRSPNKARDCSRSRSPYKARDRSRSRSPNK 457
           + ++SP KA+   +  ++SP +A+   +  ++SP + +   +++SP K      ++SP K
Sbjct: 596 AEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTK----EEAKSPEK 651

Query: 458 AR--DHSRSRSPNKARDRSRSRSPSKERDHSQLGSPSKERDHRRSRSPSKERQCRQSRSS 515
           A+  +   ++SP KA+   ++ + S E+  S + + +K  +  +++SP KE      ++ 
Sbjct: 652 AKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPE--KAKSPVKEEAKSPEKAK 709

Query: 516 SKERDHRRSRSPSKERQRRQSRSPNKERDRSQSRSPSEEREHRQSRSPSKERDRRRWRSP 575
           S  ++  +S   +K   + ++++P K +   +  + S E+     ++ + +      ++P
Sbjct: 710 SPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTP 769

Query: 576 SKERERRQSRSSSEERDHSRSRSPNKQSGYSRPRASSKEKAHSRS---RTPSKEGNHSQS 632
           +KE  R     S  ++   +++SP K+   S  +A S  K  +++     P KE   S  
Sbjct: 770 AKEEAR-----SPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPV 824

Query: 633 RTSSKESDPSQSTVPRSPDWKRSP 656
           +   K  +      P+  + +++P
Sbjct: 825 KEEEKPQEVKVKEPPKKAEEEKAP 848



 Score = 92.8 bits (229), Expect = 1e-18
 Identities = 96/552 (17%), Positives = 225/552 (40%), Gaps = 55/552 (9%)

Query: 33   KSTKSATPNRSLVPTKPATS--RNSVMSPSSSKSTKSTSTKRAPSNRPS---SRSRVRSK 87
            + TKS     +  P K A S  +    SP+ +KS +    K +P+   S   ++S  + +
Sbjct: 499  EETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAK-SPAEVKSPEKAKSPAKEE 557

Query: 88   ARTPSRVSTDTRTSKASKASDVRCHQRRGTHSRGRTPGRRGSRS--SKRSPSRASTPGRI 145
            A++P    +  +  +A   ++V+  ++       ++P +  ++S    +SP +A +P + 
Sbjct: 558  AKSPPEAKSPEK-EEAKSPAEVKSPEK------AKSPAKEEAKSPAEAKSPEKAKSPVKE 610

Query: 146  RTHG---ARPGMASRVRTPTSQQKGSRGKSYGRPRTSNRERSDSQPRNLSKKSYRPPGG- 201
                   A+  +    ++P   +   + KS  +    + E++ S  +  +K   +     
Sbjct: 611  EAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPV 670

Query: 202  SGIGRSSELAVTPSTAKCQTPTGIPSKEKSDNPSPSSSRKVKSYGQMIIPSREKSYSPTE 261
                +S E A +P  A+ ++P    S  K +  SP  ++          P +E++ SP +
Sbjct: 671  KAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKS---------PVKEEAKSPEK 721

Query: 262  MSSRVKSYNQASTRSRPQSHSQSRSPRRSRSGSQKRTHSRVRSHSWKRNHSRARSRTRKG 321
              S VK   +   +++     +++SP +++S  + +T       +       ARS   K 
Sbjct: 722  AKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADK- 780

Query: 322  ILSQMGRHSQSRSHSKGKSQNQSRTPRRGRSHNWSRN-PSKERSHSHSRSSSKERDHRGS 380
                    ++S    + KS  ++++P +  +    +  P KE   S  +   K ++ +  
Sbjct: 781  ----FPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVK 836

Query: 381  SSPRKESGRSQSGSPNKQRDHSRSRSPNKARDRSRSRSPYKARDRSRSRSPNKARDCSRS 440
              P+K        +P  +      +  +K  +  +  +P    +  +  +  K ++    
Sbjct: 837  EPPKKAEEEKAPATPKTEE-----KKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVE 891

Query: 441  RSPYKARDRSRSRSPNK-----------ARDHSRSRSPNKARDRSRSRSPSKERDHSQLG 489
                +A D+ +  +P K           A+   ++    K  D ++++ PSK  +  +  
Sbjct: 892  AKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAA 951

Query: 490  SPSKERDHRRSRSPSKERQCRQSRSSSKERDHRRSRSPSKERQRRQSRSPNKERDRSQSR 549
               K+    +++ P ++ +   + + +KE D   S+ PSK +  +  +S     D+  S+
Sbjct: 952  PEKKDTKEEKAKKPEEKPK---TEAKAKEDDKTLSKEPSKPKAEKAEKS--SSTDQKDSK 1006

Query: 550  SPSEEREHRQSR 561
             P +  E + ++
Sbjct: 1007 PPEKATEDKAAK 1018



 Score = 75.9 bits (185), Expect = 1e-13
 Identities = 100/552 (18%), Positives = 214/552 (38%), Gaps = 92/552 (16%)

Query: 1    MSSPKRSSKPSMSLA---PSGSSMPTADPKPPASLKSTKSATPNRSLVPTK-PATSRNSV 56
            + SP+++  P+   A   P   S    + K PA +KS     P ++  P K  A S    
Sbjct: 544  VKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKS-----PEKAKSPAKEEAKSPAEA 598

Query: 57   MSPSSSKSTKSTSTKRAPSNRPSSRSRVRSKARTPSRVSTDTRTSKASKASDVRCHQRRG 116
             SP  +KS      K    +   ++S V+ +A++P+ V +  +    +K       +   
Sbjct: 599  KSPEKAKS----PVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTK-------EEAK 647

Query: 117  THSRGRTPGRRGSRSSKRSPSRASTPGRIRTHGARPGMASRVRTPTSQQKGS--RGKSYG 174
            +  + ++P     +   +SP +A +P  ++     P    + ++P   +  S  + KS  
Sbjct: 648  SPEKAKSP----EKEEAKSPEKAKSP--VKAEAKSP---EKAKSPVKAEAKSPEKAKSPV 698

Query: 175  RPRTSNRERSDSQPRNLSKKSYRPPGGSGIGRSSELAVTPSTAKCQTPTGIPSKEKSDNP 234
            +    + E++ S  +  +K   +           E A TP  AK        S EK+ +P
Sbjct: 699  KEEAKSPEKAKSPVKEEAKSPEKAK-----SPVKEEAKTPEKAKSPVKEEAKSPEKAKSP 753

Query: 235  SPSSSRKVKSYGQMIIPSREKSYSPTEMSSRVKSYNQASTRSRPQSHSQSRSPRRSRSGS 294
              + +  VKS  +   P++E++ SP +                       + P +++S  
Sbjct: 754  EKAKTLDVKS-PEAKTPAKEEARSPAD-----------------------KFPEKAKSPV 789

Query: 295  QKRTHSRVRSHSWKRNHSRARSRTRKGILSQMGRHSQSRSHSKGKSQNQSRTPRRGRSHN 354
            ++   S  ++ S  +  ++A     K I  +    S  +   K +       P++     
Sbjct: 790  KEEVKSPEKAKSPLKEDAKA---PEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEK 846

Query: 355  WSRNPSKERSHSHSRSSSKERDHRGSSSPRKESGRSQSGSPNKQRDHSRSRSPNKARDRS 414
                P  E          +++D +   +P+KE       +P  + +  +  +  K ++  
Sbjct: 847  APATPKTE----------EKKDSKKEEAPKKE-------APKPKVEEKKEPAVEKPKESK 889

Query: 415  RSRSPYKARDRSRSRSPNKARDCSRSRSPYKARDRSRSRSPNKARDHSRSRSPNKARDRS 474
                  +A D+ +  +P K    ++      A+ + ++    K  D ++++ P+K  ++ 
Sbjct: 890  VEAKKEEAEDKKKVPTPEKEAP-AKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKK 948

Query: 475  RSRSPSKERDHSQLGSP---------SKERDHRRSRSPSKERQCRQSRSSSKERDHRRSR 525
             +    K+    +   P         +KE D   S+ PSK +  +  +SSS   D + S+
Sbjct: 949  EAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSS--TDQKDSK 1006

Query: 526  SPSKERQRRQSR 537
             P K  + + ++
Sbjct: 1007 PPEKATEDKAAK 1018



 Score = 53.5 bits (127), Expect = 7e-07
 Identities = 40/210 (19%), Positives = 94/210 (44%), Gaps = 19/210 (9%)

Query: 504 SKERQCRQSRSSSKERDHRRSRSPSKERQRRQSRSPNKERDRSQSRSPSEEREHRQSRSP 563
           ++E Q  +  +  +E++ +      +E    +     +E  +S    P+EE    +  + 
Sbjct: 461 TEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGEEETKSP---PAEEAASPEKEAK 517

Query: 564 SKERDRRRWRSPSKERERRQSRSSSEERDHSRSRSPNKQSGYSRPRASSKEKAHSRSRTP 623
           S  ++  +  + +K  E+ +++S +E +   +++SP K+   S P A S EK  ++S  P
Sbjct: 518 SPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKS--P 575

Query: 624 SKEGNHSQSRTSSKESDPSQSTVPRSPDWKRSPTRTSSLSQNRTPSKTSSHSPSTFPSGG 683
           ++  +  ++++ +KE               +SP    S  + ++P K  + SP+   S  
Sbjct: 576 AEVKSPEKAKSPAKEE-------------AKSPAEAKSPEKAKSPVKEEAKSPAEAKSPV 622

Query: 684 QTLSQDDSQADATTSKATLPGERSSSSSSK 713
           +  ++  ++   +  KA  P +  + S  K
Sbjct: 623 KEEAKSPAEV-KSPEKAKSPTKEEAKSPEK 651


>gi|6631100 natural killer-tumor recognition sequence [Homo sapiens]
          Length = 1462

 Score =  117 bits (293), Expect = 4e-26
 Identities = 201/818 (24%), Positives = 299/818 (36%), Gaps = 131/818 (16%)

Query: 2   SSPKRSSKPSMSLAPSGSSMPTADPKPPASLKSTKSATP-----NRSLVPTKPATSRNSV 56
           SS + SS+  +    S        PK   S K  K A+      N+  +  K  + R+  
Sbjct: 206 SSSESSSESELEHERSRRRKHKRRPKVKRSKKRRKEASSSEEPRNKHAMNPKGHSERSDT 265

Query: 57  MSPSSSKSTKSTSTKRAPSNRPSSRSRV---RSKARTPSRVSTDTRTSKASKASDVRCHQ 113
              +  +S  S++ +  P  RP     V   R   R    V T     K    + +   Q
Sbjct: 266 ---NEKRSVDSSAKREKPVVRPEEIPPVPENRFLLRRDMPVVTAEPEPKIPDVAPIVSDQ 322

Query: 114 RRGTHSRGRTPGRRGS-------RSSKRSPSRASTPGRIRTHGARPGMASRVRTPTSQQK 166
           +      GR    RG+       RS   S S          H        R   P S +K
Sbjct: 323 KPSVSKSGRKIKGRGTIRYHTPPRSRSCSESDDDDSSETPPHWKEEMQRLRAYRPPSGEK 382

Query: 167 GSRGKSYGRPRTSN-RERSDSQ-PRNLSKKSY-------RPPGGSGIGRSSELAVTPSTA 217
            S+G     P +S   ERS SQ  R+ S   Y       R  G     R  +        
Sbjct: 383 WSKGDKLSDPCSSRWDERSLSQRSRSWSYNGYYSDLSTARHSGHHKKRRKEKKVKHKKKG 442

Query: 218 KCQT---------------PTGIPSKEKSDNPSPSSSRKVKSYGQMIIPS-----REKSY 257
           K Q                P+ I S + S     SS  + +S     + S     R+ S 
Sbjct: 443 KKQKHCRRHKQTKKRRILIPSDIESSKSSTRRMKSSCDRERSSRSSSLSSHHSSKRDWSK 502

Query: 258 SPTEMSSRVKSYNQASTRSRPQSHSQSRSPRRSRSGSQKRTHSRVRSHSW---KRNHSRA 314
           S  ++ S +   ++ S RS+  S S SR   RSR+ S+  +HSR RS S    K  H + 
Sbjct: 503 SDKDVQSSLTHSSRDSYRSKSHSQSYSRGSSRSRTASKSSSHSRSRSKSRSSSKSGHRKR 562

Query: 315 RSRTRKGILSQMGRHSQSRSH----SKGKSQN-----------------QSRTPRRGRSH 353
            S++ +   SQ+  +   ++     +  +++N                  S  P R +  
Sbjct: 563 ASKSPRKTASQLSENKPVKTEPLRATMAQNENVVVQPVVAENIPVIPLSDSPPPSRWKPG 622

Query: 354 NWSRNPSKERSHSHSRSSSKERDHRGSSSPR--KESGRSQSGSPNKQRDHSRSRSPNKAR 411
                PS ER       ++     + + S    KE+G S S    ++   S   + +K  
Sbjct: 623 QKPWKPSYERIQEMKAKTTHLLPIQSTYSLANIKETGSSSSYHKREKNSESDQSTYSKYS 682

Query: 412 DRSRSRSPYKARDRSRSRSPNKARDCSRSRSPYKARDRSRSRSPNKARDHSRSRSPNKAR 471
           DRS   SP     RSRSRS       SRSRS      RS +RS + A  HSRSRSP+   
Sbjct: 683 DRSSESSP-----RSRSRS-------SRSRS----YSRSYTRSRSLASSHSRSRSPS--- 723

Query: 472 DRSRSRSPSKERDHSQ---------LGSPSKERDHRRSRSPSKERQCRQSRSSSKERDHR 522
             SRS S +K  DHSQ         + S    R  RR RS  K+      + SS      
Sbjct: 724 --SRSHSRNKYSDHSQCSRSSSYTSISSDDGRRAKRRLRSSGKKNSVSHKKHSSSSEKTL 781

Query: 523 RSRSPSKERQRRQSRSPNKERDRSQSRSPSEEREHRQSRS-PSKERDRRRWRSPSKERER 581
            S+      +    R  ++ R      S SE+   + ++S   KE+  +  R+ +K+ + 
Sbjct: 782 HSKYVKGRDRSSCVRKYSESRSSLDYSSDSEQSSVQATQSAQEKEKQGQMERTHNKQEKN 841

Query: 582 RQSRSSSEER---------------DHSRSRSPNKQSGYSRPRASSKEKAHSRSRTPSKE 626
           R    S  ER               DH R+ S  K+  Y+  +  S+  +       SK 
Sbjct: 842 RGEEKSKSERECPHSKKRTLKENLSDHLRNGSKPKRKNYAGSKWDSESNSERDVTKNSKN 901

Query: 627 GNHSQS------RTSSKESDPSQSTVPRSPDWKRSPTRTSSLSQNRTPSKTSSHSPSTFP 680
            +H  S       TS  ES+ S+  +   P  K S    +SL  +    K+S    ST  
Sbjct: 902 DSHPSSDKEEGEATSDSESEVSEIHIKVKPTTKSS--TNTSLPDDNGAWKSSKQRTSTSD 959

Query: 681 SGGQTLSQDDS----QADATTSKATLPGERSSSSSSKL 714
           S G   + +++    Q     SK  L  E +     KL
Sbjct: 960 SEGSCSNSENNRGKPQKHKHGSKENLKREHTKKVKEKL 997



 Score = 85.5 bits (210), Expect = 2e-16
 Identities = 150/730 (20%), Positives = 280/730 (38%), Gaps = 93/730 (12%)

Query: 29   PASLKSTKSATPNRSLVPTKPATSRNSVMSPSSS------KSTKSTSTKRAPSNRPSSRS 82
            P+ ++S+KS+T        +  +SR+S +S   S      KS K   +    S+R S RS
Sbjct: 462  PSDIESSKSSTRRMKSSCDRERSSRSSSLSSHHSSKRDWSKSDKDVQSSLTHSSRDSYRS 521

Query: 83   --------RVRSKARTPSRVSTDTRTSKASKASDVRCHQRRGTHSRGRTPGRRGSRSSKR 134
                    R  S++RT S+ S+ +R+   S++S    H++R + S  +T  +       +
Sbjct: 522  KSHSQSYSRGSSRSRTASKSSSHSRSRSKSRSSSKSGHRKRASKSPRKTASQLSENKPVK 581

Query: 135  SPSRASTPGRIRTHGARPGMASRVRT-PTSQQKG-SRGKSYGRPRTSNRERSDSQPRNLS 192
            +    +T  +      +P +A  +   P S     SR K   +P   + ER        +
Sbjct: 582  TEPLRATMAQNENVVVQPVVAENIPVIPLSDSPPPSRWKPGQKPWKPSYERIQEMKAKTT 641

Query: 193  -----KKSYRPPGGSGIGRSSELAVTPSTAKCQTPTGIPSKEKSDNPSPSS---SRKVKS 244
                 + +Y        G SS        ++    T     ++S   SP S   S + +S
Sbjct: 642  HLLPIQSTYSLANIKETGSSSSYHKREKNSESDQSTYSKYSDRSSESSPRSRSRSSRSRS 701

Query: 245  YGQMIIPSRE------KSYSPTEMSSRVKSYNQASTRSRPQSHSQ------SRSPRRSRS 292
            Y +    SR       +S SP+  S     Y+  S  SR  S++        R+ RR RS
Sbjct: 702  YSRSYTRSRSLASSHSRSRSPSSRSHSRNKYSDHSQCSRSSSYTSISSDDGRRAKRRLRS 761

Query: 293  GSQKRT--HSRVRSHSWKRNHSR-ARSRTRKGILSQMGRHSQSRSHSKGKSQN-----QS 344
              +K +  H +  S S K  HS+  + R R   + +      S  +S    Q+     QS
Sbjct: 762  SGKKNSVSHKKHSSSSEKTLHSKYVKGRDRSSCVRKYSESRSSLDYSSDSEQSSVQATQS 821

Query: 345  RTPRRGRSHNWSRNPSKERSHSHSRSSSKERDHRGSSSPRKE--SGRSQSGSPNKQRDHS 402
               +  +      +  +E++    +S S+           KE  S   ++GS  K+++++
Sbjct: 822  AQEKEKQGQMERTHNKQEKNRGEEKSKSERECPHSKKRTLKENLSDHLRNGSKPKRKNYA 881

Query: 403  RSRSPNKARDRSRSRSPYKARDRSRSRSPNKARDCSRSRSPYKARDRSRSRSPNKARDHS 462
             S+  +++             +  R  + N   D   S    +    S S S        
Sbjct: 882  GSKWDSES-------------NSERDVTKNSKNDSHPSSDKEEGEATSDSES-------E 921

Query: 463  RSRSPNKARDRSRSRSPSKERDHSQLGSPSKERDHRRSRSPSKERQCRQSRSS-SKERDH 521
             S    K +  ++S + +   D +     SK+    R+ +   E  C  S ++  K + H
Sbjct: 922  VSEIHIKVKPTTKSSTNTSLPDDNGAWKSSKQ----RTSTSDSEGSCSNSENNRGKPQKH 977

Query: 522  RRSRSPSKERQRRQSRSPNKERDRSQSRSPSEEREHRQSRSPSKERDRRRWRSPSKERER 581
            +     SKE  +R+     KE+ + +     ++++H+      K +    W+ P +  E 
Sbjct: 978  KHG---SKENLKREHTKKVKEKLKGK-----KDKKHK----APKRKQAFHWQPPLEFGEE 1025

Query: 582  RQSRSSSEERDHSRSRSPNKQSGYSRPRASSKEKAHSRSRTPSKEGNHSQSRTSSKESDP 641
             +     EE D  +    +K+   S    + K+    ++   S+E    +  T +  SD 
Sbjct: 1026 EE-----EEIDDKQVTQESKEKKVSENNETIKDNI-LKTEKSSEEDLSGKHDTVTVSSDL 1079

Query: 642  SQSTVPRSPDWKRSPTRTS-SLSQNRTPSKTSSHSPSTFPSGGQTLSQDDSQADATTSKA 700
             Q T     D K S + T+ +  +N    +   H   + P+G + + Q D   +  T   
Sbjct: 1080 DQFT---KDDSKLSISPTALNTEENVACLQNIQHVEESVPNGVEDVLQTDDNMEICTPDR 1136

Query: 701  TLPGERSSSS 710
            + P +   +S
Sbjct: 1137 SSPAKVEETS 1146



 Score = 81.3 bits (199), Expect = 3e-15
 Identities = 89/307 (28%), Positives = 129/307 (42%), Gaps = 46/307 (14%)

Query: 164  QQKGSRGKSYGRPRTSNRERSDSQPRNLSKKSYRPPGGSGIGRSSELAVTPSTAKCQTPT 223
            Q   S   +     T  +E ++    NL  K ++P  G G   ++  A T S  + +  T
Sbjct: 1194 QDSSSASLASAGESTGKKEVAEKSQINLIDKKWKPLQGVG-NLAAPNAATSSAVEVKVLT 1252

Query: 224  GIPSKEKSDNPSPSSSRKVKSYGQMIIPSREKSYSPTEMSSRVKSYNQASTRSRPQ--SH 281
             +P  +         S+     G +    R+ +     ++ R ++   +S    P     
Sbjct: 1253 TVPEMKPQGLRIEIKSKNKVRPGSLFDEVRKTA----RLNRRPRNQESSSDEQTPSRDDD 1308

Query: 282  SQSRSPRRSRSGSQKRTHSRVRSHSWKRNHSRARSRTRKGILSQMGRHSQSRSHSKGKSQ 341
            SQSRSP RSRS S+ ++  R RS S+  + SR+RS T                     S 
Sbjct: 1309 SQSRSPSRSRSKSETKSRHRTRSVSYSHSRSRSRSST---------------------SS 1347

Query: 342  NQSRTPRRGRSHNWSRNPSKERSHSHSRSSSKERDHRGSSSPRKESGRSQSGSPNKQRDH 401
             +SR+  R RS  W    S+ R+ S S S    + HR SS  R    RS S  P     H
Sbjct: 1348 YRSRSYSRSRSRGWY---SRGRTRSRSSSYRSYKSHRTSSRSR---SRSSSYDP-----H 1396

Query: 402  SRSRS----PNKARDRSRSRSPYKARDRSRSRSPNKARDCSRSRSPYKARDRSRS--RSP 455
            SRSRS       +R RSRSRS  ++    R RS N+     RS       DRS S  RSP
Sbjct: 1397 SRSRSYTYDSYYSRSRSRSRS-QRSDSYHRGRSYNRRSRSCRSYGSDSESDRSYSHHRSP 1455

Query: 456  NKARDHS 462
            +++  +S
Sbjct: 1456 SESSRYS 1462



 Score = 76.3 bits (186), Expect = 9e-14
 Identities = 71/210 (33%), Positives = 107/210 (50%), Gaps = 28/210 (13%)

Query: 360  SKERSHSHSRSSSKERDHRGSSSPRKESGRSQSGSPNKQRDHSRSRSPNKARDRSRSRSP 419
            SK +    S      +  R +  PR +   S   +P++  D S+SRSP+++R +S ++S 
Sbjct: 1268 SKNKVRPGSLFDEVRKTARLNRRPRNQESSSDEQTPSRD-DDSQSRSPSRSRSKSETKSR 1326

Query: 420  YKARD------RSRSRSPN---KARDCSRSRSP-YKARDRSRSRSPNKARDHSRSRSPNK 469
            ++ R       RSRSRS     ++R  SRSRS  + +R R+RSRS +      RS   ++
Sbjct: 1327 HRTRSVSYSHSRSRSRSSTSSYRSRSYSRSRSRGWYSRGRTRSRSSS-----YRSYKSHR 1381

Query: 470  ARDRSRSRSPSKERDHSQLGSPSKERDHRRSRSPSKERQCRQSRSSSKERDHRRSRSPSK 529
               RSRSRS S +  HS+  S + +  + RSRS S     R  RS S    + R RS ++
Sbjct: 1382 TSSRSRSRSSSYD-PHSRSRSYTYDSYYSRSRSRS-----RSQRSDS----YHRGRSYNR 1431

Query: 530  ERQRRQSRSPNKERDRSQS--RSPSEEREH 557
              +  +S   + E DRS S  RSPSE   +
Sbjct: 1432 RSRSCRSYGSDSESDRSYSHHRSPSESSRY 1461



 Score = 75.1 bits (183), Expect = 2e-13
 Identities = 64/196 (32%), Positives = 96/196 (48%), Gaps = 26/196 (13%)

Query: 416  SRSPYKARDRSRSRSPNKARDCSRSRSPYKARDRSRSRSPNKARDHSRSRSPNKARDRSR 475
            +R P      S  ++P++  D S+SRSP      SRSRS ++ +   R+RS + +  RSR
Sbjct: 1288 NRRPRNQESSSDEQTPSRDDD-SQSRSP------SRSRSKSETKSRHRTRSVSYSHSRSR 1340

Query: 476  SRSPSKERDHSQLGSPSKERDHRRSRSPSKERQCRQSRSSSKERDHRRSRSPSKERQRRQ 535
            SRS +         S  + R + RSRS     + R    SS  R ++  R+ S+ R R  
Sbjct: 1341 SRSST---------SSYRSRSYSRSRSRGWYSRGRTRSRSSSYRSYKSHRTSSRSRSRSS 1391

Query: 536  SRSPNKERDRSQSRSPSEEREHRQSRSPSK-ERDRRRWRSPSKERERRQSRS----SSEE 590
            S  P+     S+SRS + +  + +SRS S+ +R     R  S  R  R  RS    S  +
Sbjct: 1392 SYDPH-----SRSRSYTYDSYYSRSRSRSRSQRSDSYHRGRSYNRRSRSCRSYGSDSESD 1446

Query: 591  RDHSRSRSPNKQSGYS 606
            R +S  RSP++ S YS
Sbjct: 1447 RSYSHHRSPSESSRYS 1462



 Score = 67.4 bits (163), Expect = 4e-11
 Identities = 61/188 (32%), Positives = 95/188 (50%), Gaps = 21/188 (11%)

Query: 498  RRSRSPSKERQCRQSRSSSKERDHRRSRSPSKERQRRQSRSPNKERDRSQSRSPSEEREH 557
            R +R P  +      ++ S++ D  +SRSPS+ R + +++S ++ R  S S S S  R  
Sbjct: 1286 RLNRRPRNQESSSDEQTPSRD-DDSQSRSPSRSRSKSETKSRHRTRSVSYSHSRSRSRSS 1344

Query: 558  RQS-RSPSKERDRRR-WRSPSKERERRQSRSSSEERDHSRSRSPNKQSGYSRPRASSKEK 615
              S RS S  R R R W S    R R +SRSSS      RS   ++ S  SR R+SS + 
Sbjct: 1345 TSSYRSRSYSRSRSRGWYS----RGRTRSRSSSY-----RSYKSHRTSSRSRSRSSSYDP 1395

Query: 616  AHSRSRTPSKEGNHSQSRTSSKESDPSQSTVPRSPDWKRSPTRT--------SSLSQNRT 667
             HSRSR+ + +  +S+SR+ S+          RS + +    R+         S S +R+
Sbjct: 1396 -HSRSRSYTYDSYYSRSRSRSRSQRSDSYHRGRSYNRRSRSCRSYGSDSESDRSYSHHRS 1454

Query: 668  PSKTSSHS 675
            PS++S +S
Sbjct: 1455 PSESSRYS 1462



 Score = 66.2 bits (160), Expect = 1e-10
 Identities = 90/293 (30%), Positives = 136/293 (46%), Gaps = 45/293 (15%)

Query: 230  KSDNPSPSSSRKVKSYGQMIIPSR------EKSYSPTEMSSRVKSYNQASTRSRPQSHSQ 283
            K D+ S S +   +S G+  +  +      +K + P +    + + N A+T S  +    
Sbjct: 1193 KQDSSSASLASAGESTGKKEVAEKSQINLIDKKWKPLQGVGNLAAPN-AATSSAVEVKVL 1251

Query: 284  SRSPRRSRSGSQKRTHSRVRSHSWKRNHSRARSRTRKGILSQMGRHSQSRSHSKGKSQN- 342
            +  P     G +      ++S +  R  S      +   L++  R+ +S S  +  S++ 
Sbjct: 1252 TTVPEMKPQGLR----IEIKSKNKVRPGSLFDEVRKTARLNRRPRNQESSSDEQTPSRDD 1307

Query: 343  --QSRTPRRGRSHNW--SRNPSKERSHSHSRSSSKERDHRGSSSPRKESGRSQSGSPNKQ 398
              QSR+P R RS +   SR+ ++  S+SHSRS S     R S+S    S RS+S S ++ 
Sbjct: 1308 DSQSRSPSRSRSKSETKSRHRTRSVSYSHSRSRS-----RSSTS----SYRSRSYSRSRS 1358

Query: 399  RD-HSRSRSPNKARDRSRSRSPYKA-RDRSRSRSPNKARD-CSRSRS----PYKARDRSR 451
            R  +SR R+    R RS S   YK+ R  SRSRS + + D  SRSRS     Y +R RSR
Sbjct: 1359 RGWYSRGRT----RSRSSSYRSYKSHRTSSRSRSRSSSYDPHSRSRSYTYDSYYSRSRSR 1414

Query: 452  SRSPNKARDHSRSRSPNKARDRSRSRSPSKERDHSQLGSPSKERDHRRSRSPS 504
            SRS  ++  + R RS N+     RS     E D S          H RS S S
Sbjct: 1415 SRS-QRSDSYHRGRSYNRRSRSCRSYGSDSESDRSY--------SHHRSPSES 1458



 Score = 63.9 bits (154), Expect = 5e-10
 Identities = 63/187 (33%), Positives = 94/187 (50%), Gaps = 20/187 (10%)

Query: 464  SRSPNKARDRSRSRSPSKERDHSQLGSPSKERDHRRSRSPSKERQCRQSRSSSKERDHRR 523
            +R P      S  ++PS++ D SQ  SPS+ R    S+S +K R   +S S S  R   R
Sbjct: 1288 NRRPRNQESSSDEQTPSRD-DDSQSRSPSRSR----SKSETKSRHRTRSVSYSHSRSRSR 1342

Query: 524  SRSPSKERQRRQSRSPNK---ERDRSQSRSPSEEREHRQSRSPSKERDRRRWRSPSKERE 580
            S S S  R R  SRS ++    R R++SRS S  R ++  R+ S+ R R     P     
Sbjct: 1343 S-STSSYRSRSYSRSRSRGWYSRGRTRSRS-SSYRSYKSHRTSSRSRSRSSSYDP---HS 1397

Query: 581  RRQSRSSSEERDHSRSRSPNKQS-GYSRPRASSKEKAHSRSRTPSKEGNHSQS-RTSSKE 638
            R +S +       SRSRS +++S  Y R R+ ++     RSR+    G+ S+S R+ S  
Sbjct: 1398 RSRSYTYDSYYSRSRSRSRSQRSDSYHRGRSYNR-----RSRSCRSYGSDSESDRSYSHH 1452

Query: 639  SDPSQST 645
              PS+S+
Sbjct: 1453 RSPSESS 1459



 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 99/387 (25%), Positives = 139/387 (35%), Gaps = 79/387 (20%)

Query: 360 SKERSHSHSRSSSK-ERDHRGS-------------SSPRKESGRSQSGSPNKQ----RDH 401
           S   S S S SSS+ E +H  S             S  R++   S     NK     + H
Sbjct: 200 SSSNSSSSSESSSESELEHERSRRRKHKRRPKVKRSKKRRKEASSSEEPRNKHAMNPKGH 259

Query: 402 SRSRSPNKARDRSRSRSPYKARDRSRSRSPNKARDCSRSRSPYKARDRSRSRSPNKA--- 458
           S     N+ R    S    K   R     P         R           + P+ A   
Sbjct: 260 SERSDTNEKRSVDSSAKREKPVVRPEEIPPVPENRFLLRRDMPVVTAEPEPKIPDVAPIV 319

Query: 459 --RDHSRSRSPNKARDRS--------RSRSPSKERDHSQLGSPSKERDH----RRSRSPS 504
             +  S S+S  K + R         RSRS S+  D     +P   ++     R  R PS
Sbjct: 320 SDQKPSVSKSGRKIKGRGTIRYHTPPRSRSCSESDDDDSSETPPHWKEEMQRLRAYRPPS 379

Query: 505 KERQCRQSRSS---SKERDHR----RSRSPS------------KERQRRQSRSPNKERDR 545
            E+  +  + S   S   D R    RSRS S                 ++ R   K + +
Sbjct: 380 GEKWSKGDKLSDPCSSRWDERSLSQRSRSWSYNGYYSDLSTARHSGHHKKRRKEKKVKHK 439

Query: 546 SQSRSPSEEREHRQSR----------SPSKERDRRRWRSPSKERERRQSRSS---SEERD 592
            + +     R H+Q++            SK   RR   S  +ER  R S  S   S +RD
Sbjct: 440 KKGKKQKHCRRHKQTKKRRILIPSDIESSKSSTRRMKSSCDRERSSRSSSLSSHHSSKRD 499

Query: 593 HSRSRSPNKQSGYSRPRASSKEKAH--------SRSRTPSKEGNHSQSRTSSKESDPSQS 644
            S+S    + S     R S + K+H        SRSRT SK  +HS+SR+ S+ S  S  
Sbjct: 500 WSKSDKDVQSSLTHSSRDSYRSKSHSQSYSRGSSRSRTASKSSSHSRSRSKSRSSSKSGH 559

Query: 645 TVPRSPDWKRSPTRTSSLSQNRTPSKT 671
               S    +SP +T+S      P KT
Sbjct: 560 RKRAS----KSPRKTASQLSENKPVKT 582



 Score = 53.5 bits (127), Expect = 7e-07
 Identities = 76/356 (21%), Positives = 126/356 (35%), Gaps = 37/356 (10%)

Query: 373 KERDHRGSSSPRKESGRSQSGSPNKQRDHSRSRSPNKARDRSRSRSPYKARDRSRSRSPN 432
           K+  H   S     S  S   S   + +H RSR           R  +K R + + RS  
Sbjct: 190 KKPTHSEGSDSSSNSSSSSESSSESELEHERSR-----------RRKHKRRPKVK-RSKK 237

Query: 433 KARDCSRSRSPYKARDRSRSRSPNKARDHSRSRSPNKAR--DRSRSRSPSKERDHSQLGS 490
           + ++ S S  P       R++     + HS     N+ R  D S  R     R       
Sbjct: 238 RRKEASSSEEP-------RNKHAMNPKGHSERSDTNEKRSVDSSAKREKPVVRPEEIPPV 290

Query: 491 PSKERDHRRSR---SPSKERQCRQSRSSSKERDHRRSRSPSKERQRRQSRSPNKERDRSQ 547
           P      RR     +   E +         ++    S+S  K + R   R     R RS 
Sbjct: 291 PENRFLLRRDMPVVTAEPEPKIPDVAPIVSDQKPSVSKSGRKIKGRGTIRYHTPPRSRSC 350

Query: 548 SRSPSEEREHRQSRSPSKERDRRRWRSPSKERERRQSRSSS------EERDHSRSRSPNK 601
           S S  ++          + +  R +R PS E+  +  + S       +ER  S+      
Sbjct: 351 SESDDDDSSETPPHWKEEMQRLRAYRPPSGEKWSKGDKLSDPCSSRWDERSLSQRSRSWS 410

Query: 602 QSGYSRPRASSKEKAHSRSRTPSKEGNHSQSRTSSKESDPSQST------VPRSPDWKRS 655
            +GY    ++++   H + R   K+  H +     K     + T      +P   +  +S
Sbjct: 411 YNGYYSDLSTARHSGHHKKRRKEKKVKHKKKGKKQKHCRRHKQTKKRRILIPSDIESSKS 470

Query: 656 PTRTSSLSQNRTPSKTSSHSPSTFPSGGQTLSQDDSQADATTSKATLPGERSSSSS 711
            TR    S +R  S  SS S S+  S  +  S+ D    ++ + ++    RS S S
Sbjct: 471 STRRMKSSCDRERSSRSS-SLSSHHSSKRDWSKSDKDVQSSLTHSSRDSYRSKSHS 525



 Score = 50.1 bits (118), Expect = 7e-06
 Identities = 158/749 (21%), Positives = 266/749 (35%), Gaps = 108/749 (14%)

Query: 27   KPPASLKSTKSATPNRSLVPTKPATSRNSVMSPSSSKSTKSTS--TKRAPSNRPSSRSRV 84
            K   S +ST S   +RS   +  + SR+S     S   T+S S  +  + S  PSSRS  
Sbjct: 669  KNSESDQSTYSKYSDRSSESSPRSRSRSSRSRSYSRSYTRSRSLASSHSRSRSPSSRSHS 728

Query: 85   RSKARTPSRVSTDTRTSKASKASDVRCHQR-RGTHSRGRTPGRRGSRSSKRSPSRASTPG 143
            R+K    S+ S  +  +  S     R  +R R +  +     ++ S SS+++       G
Sbjct: 729  RNKYSDHSQCSRSSSYTSISSDDGRRAKRRLRSSGKKNSVSHKKHSSSSEKTLHSKYVKG 788

Query: 144  RIRTHGARPGMASRVR--------------TPTSQQKGSRG----------KSYGRPRT- 178
            R R+   R    SR                T ++Q+K  +G          K+ G  ++ 
Sbjct: 789  RDRSSCVRKYSESRSSLDYSSDSEQSSVQATQSAQEKEKQGQMERTHNKQEKNRGEEKSK 848

Query: 179  SNRERSDSQPRNLSKK-SYRPPGGS--------GIGRSSELAVTPSTAKCQTPTGIPSKE 229
            S RE   S+ R L +  S     GS        G    SE        K       PS +
Sbjct: 849  SERECPHSKKRTLKENLSDHLRNGSKPKRKNYAGSKWDSESNSERDVTKNSKNDSHPSSD 908

Query: 230  KSDNPSPSSSRKVKSYGQMIIPSREKSYSPTEMSSRVKSYNQASTRSRPQSHSQSRSPRR 289
            K +  + S S    S   + +    KS + T +       +  + +S  Q  S S S   
Sbjct: 909  KEEGEATSDSESEVSEIHIKVKPTTKSSTNTSLPD-----DNGAWKSSKQRTSTSDSEGS 963

Query: 290  SRSGSQKRTHSRVRSHSWKRNHSRARSRTRKGILSQMGRHSQSRSHSKGKSQNQSRTPRR 349
              +    R   +   H  K N  R  ++  K  L             KGK   + + P+R
Sbjct: 964  CSNSENNRGKPQKHKHGSKENLKREHTKKVKEKL-------------KGKKDKKHKAPKR 1010

Query: 350  GRSHNWSRNPSKERSHSHSRSSSKERDHRGSSSPRKESGRSQSGSPNKQRDHSRSRSPNK 409
             ++ +W   P  E          +E D +  +   KE   S++    K       +S  +
Sbjct: 1011 KQAFHWQ--PPLE----FGEEEEEEIDDKQVTQESKEKKVSENNETIKDNILKTEKSSEE 1064

Query: 410  ARDR-------SRSRSPYKARDRSRSRSPNKARDCSRSRSPYKARDRSRSRSPNKARDHS 462
                       S     +   D   S SP  A +   + +  +         PN   D  
Sbjct: 1065 DLSGKHDTVTVSSDLDQFTKDDSKLSISPT-ALNTEENVACLQNIQHVEESVPNGVEDVL 1123

Query: 463  RSRSPNKARDRSRSRSPSKERDHSQLGSPSKERDHRRSRSPSKERQCRQSRSSSKERDHR 522
            ++    +     RS SP+K  + S LG+        R  +P      +Q  ++    +H 
Sbjct: 1124 QTDDNMEICTPDRS-SPAKVEETSPLGNA-------RLDTPDINIVLKQDMAT----EHP 1171

Query: 523  RSRSPSKERQRRQSR---SPNKERDRSQSRSPSEEREHRQSRSPSKERDR--RRWR---- 573
            ++    +E    +S+      K+   S S + + E   ++  +   + +   ++W+    
Sbjct: 1172 QAEVVKQESSMSESKVLGEVGKQDSSSASLASAGESTGKKEVAEKSQINLIDKKWKPLQG 1231

Query: 574  --------SPSKERERRQSRSSSEERDHSRSRSPNKQSGYSRPRASSKE--KAHSRSRTP 623
                    + +      +  ++  E      R   K     RP +   E  K    +R P
Sbjct: 1232 VGNLAAPNAATSSAVEVKVLTTVPEMKPQGLRIEIKSKNKVRPGSLFDEVRKTARLNRRP 1291

Query: 624  SKEGNHSQSRTSSKESDPSQSTVPRSPDWKRSPTRTSSLSQNRTPSKTSSHSPSTFPSGG 683
              + + S  +T S++ D SQS   RSP   RS + T S  ++RT S + SHS S   S  
Sbjct: 1292 RNQESSSDEQTPSRDDD-SQS---RSPSRSRSKSETKS--RHRTRSVSYSHSRSR--SRS 1343

Query: 684  QTLSQDDSQADATTSKATLPGERSSSSSS 712
             T S        + S+      R+ S SS
Sbjct: 1344 STSSYRSRSYSRSRSRGWYSRGRTRSRSS 1372



 Score = 47.4 bits (111), Expect = 5e-05
 Identities = 56/195 (28%), Positives = 80/195 (41%), Gaps = 26/195 (13%)

Query: 32   LKSTKSATPNRSLVPTKPATSRNSVMSPSSSKSTKSTSTKRAPSNRPSSRSRVRSKARTP 91
            +KS     P  SL      T+R +    +   S+   +  R   ++  S SR RSK+ T 
Sbjct: 1266 IKSKNKVRPG-SLFDEVRKTARLNRRPRNQESSSDEQTPSRDDDSQSRSPSRSRSKSETK 1324

Query: 92   SRVST------DTRTSKASKASDVRCH-----QRRGTHSRGRTPGRRGS-------RSSK 133
            SR  T       +R+   S  S  R       + RG +SRGRT  R  S       R+S 
Sbjct: 1325 SRHRTRSVSYSHSRSRSRSSTSSYRSRSYSRSRSRGWYSRGRTRSRSSSYRSYKSHRTSS 1384

Query: 134  RSPSRAST---PGRIRTHGARPGMASRVRTPTSQQKGS---RGKSYGRPRTSNRERSDSQ 187
            RS SR+S+     R R++       SR R+ +  Q+     RG+SY R   S R      
Sbjct: 1385 RSRSRSSSYDPHSRSRSY-TYDSYYSRSRSRSRSQRSDSYHRGRSYNRRSRSCRSYGSDS 1443

Query: 188  PRNLSKKSYRPPGGS 202
              + S   +R P  S
Sbjct: 1444 ESDRSYSHHRSPSES 1458



 Score = 39.3 bits (90), Expect = 0.013
 Identities = 64/224 (28%), Positives = 91/224 (40%), Gaps = 59/224 (26%)

Query: 63   KSTKSTSTKRAPSNRPSSRSRVRSKARTPSRVSTDTRTSKASKASDVRCHQRRGTHSRGR 122
            ++ +S+S ++ PS    S+SR  S++R+ S   +  RT   S +           HSR R
Sbjct: 1292 RNQESSSDEQTPSRDDDSQSRSPSRSRSKSETKSRHRTRSVSYS-----------HSRSR 1340

Query: 123  TPGRRGSRSSKRSPSRASTPGRIRTHGARPGMASRVRTPTSQQKGSRGKSYGRPRTSNRE 182
            +   R S SS RS S + +  R        G  SR RT       SR  SY R   S+R 
Sbjct: 1341 S---RSSTSSYRSRSYSRSRSR--------GWYSRGRTR------SRSSSY-RSYKSHRT 1382

Query: 183  RSDSQPRNLSKKSYRPPGGSGIGRSSELAVTPSTAKCQTPTGIPSKEKSDNPSPSSSRKV 242
             S S+ R+    SY P                S ++  T     S+ +    S S S++ 
Sbjct: 1383 SSRSRSRS---SSYDP---------------HSRSRSYTYDSYYSRSR----SRSRSQRS 1420

Query: 243  KSYGQMIIPSREKSYSPTEMSSRVKSYNQASTRSRPQSHSQSRS 286
             SY       R +SY+    S R  SY   S   R  SH +S S
Sbjct: 1421 DSY------HRGRSYNRRSRSCR--SYGSDSESDRSYSHHRSPS 1456



 Score = 35.8 bits (81), Expect = 0.14
 Identities = 59/245 (24%), Positives = 86/245 (35%), Gaps = 51/245 (20%)

Query: 493 KERDHRRSRSPSKERQCRQSRSSSKERDHRRSRSPSKERQRRQSRSPNKERD--RSQSRS 550
           K+  H      S         SS  E +H RSR      +R+  R P  +R   R +  S
Sbjct: 190 KKPTHSEGSDSSSNSSSSSESSSESELEHERSR------RRKHKRRPKVKRSKKRRKEAS 243

Query: 551 PSEEREHRQSRSP---SKERDRRRWRSPSKERERRQSRSSSEE------------RD--- 592
            SEE  ++ + +P   S+  D    RS     +R +     EE            RD   
Sbjct: 244 SSEEPRNKHAMNPKGHSERSDTNEKRSVDSSAKREKPVVRPEEIPPVPENRFLLRRDMPV 303

Query: 593 ---HSRSRSPNKQSGYSRPRAS-SKEKAHSRSRTPSKEGNHSQSRTSSKESDPSQSTVPR 648
                  + P+     S  + S SK     + R   +     +SR+ S+  D   S  P 
Sbjct: 304 VTAEPEPKIPDVAPIVSDQKPSVSKSGRKIKGRGTIRYHTPPRSRSCSESDDDDSSETP- 362

Query: 649 SPDWKRSPTRTSSLSQNRTPSKTSSHSPSTFPSGGQTLSQDDSQADATTSKATLPGERSS 708
            P WK    R   L   R PS             G+  S+ D  +D  +S+     ERS 
Sbjct: 363 -PHWKEEMQR---LRAYRPPS-------------GEKWSKGDKLSDPCSSRW---DERSL 402

Query: 709 SSSSK 713
           S  S+
Sbjct: 403 SQRSR 407



 Score = 35.4 bits (80), Expect = 0.19
 Identities = 48/167 (28%), Positives = 74/167 (44%), Gaps = 35/167 (20%)

Query: 23   TADPKPPASLKSTKSATPNRSLVPTKPAT---SRNSVMSPSSSKSTKSTSTKRAPSNRPS 79
            ++D + P+    ++S +P+RS   ++  +   +R+   S S S+S  STS+ R+   R  
Sbjct: 1297 SSDEQTPSRDDDSQSRSPSRSRSKSETKSRHRTRSVSYSHSRSRSRSSTSSYRS---RSY 1353

Query: 80   SRSRVR---SKARTPSRVS---------TDTRTSKASKASDVRCHQRRGTH----SRGRT 123
            SRSR R   S+ RT SR S         T +R+   S + D     R  T+    SR R+
Sbjct: 1354 SRSRSRGWYSRGRTRSRSSSYRSYKSHRTSSRSRSRSSSYDPHSRSRSYTYDSYYSRSRS 1413

Query: 124  PGR--------RGSRSSKRSPS-----RASTPGRIRTHGARPGMASR 157
              R        RG   ++RS S       S   R  +H   P  +SR
Sbjct: 1414 RSRSQRSDSYHRGRSYNRRSRSCRSYGSDSESDRSYSHHRSPSESSR 1460



 Score = 32.7 bits (73), Expect = 1.2
 Identities = 19/87 (21%), Positives = 39/87 (44%), Gaps = 4/87 (4%)

Query: 529 KERQRRQSRSPNKERDRSQSRSPSEEREHRQSRSPSKERDRRRWRSPSKERERRQSRSSS 588
           ++++++ + S   +   + S S     E       S+ R  +R     + ++RR+  SSS
Sbjct: 186 EKKRKKPTHSEGSDSSSNSSSSSESSSESELEHERSRRRKHKRRPKVKRSKKRRKEASSS 245

Query: 589 EERDHSRSRSPNKQSGYSRPRASSKEK 615
           EE  +  + +P   S     R+ + EK
Sbjct: 246 EEPRNKHAMNPKGHS----ERSDTNEK 268


>gi|133922600 splicing factor, arginine/serine-rich 16 [Homo
           sapiens]
          Length = 674

 Score =  116 bits (291), Expect = 6e-26
 Identities = 135/459 (29%), Positives = 206/459 (44%), Gaps = 87/459 (18%)

Query: 177 RTSNRERSDSQPRNLSKKSYRPPGGSGIGRSSELAVTPSTAKCQTPTGIPSKEKSDNPSP 236
           R S R+R + + + L  +   PP               S A+  +PT  P K    +PS 
Sbjct: 265 RRSRRQRREFREKRLRGRKISPP---------------SYARRDSPTYDPYKR---SPSE 306

Query: 237 SSSRKVKSYGQMIIPSREK------SYSPTEMSSRVKSYNQAS---TRSRPQSHSQSRSP 287
           SSS   +S  +   P RE+      S+  ++  +   +   A+   T  +P +  Q   P
Sbjct: 307 SSSES-RSRSRSPTPGREEKITFITSFGGSDEEAAAAAAAAAASGVTTGKPPAPPQPGGP 365

Query: 288 RRSRSGSQKRTHSRVRSHSWKRNHSRARSRTRKGILSQMGRHSQSRSHSKGKSQNQSRTP 347
              R+ S +R  S   S S     S +RS +R          S SRS  +G    +S   
Sbjct: 366 APGRNASARRRSSSSSSSSSASRTSSSRSSSR----------SSSRSR-RGGGYYRSGRH 414

Query: 348 RRGRSHNWSRNPSKERSHSHSRSSSKERDHRGSSSPRKESGRSQSGSPNKQRDHSRSRSP 407
            R RS +WSR  S+ RS  +SRS S+ R H G  S     G   S SP ++  +   R  
Sbjct: 415 ARSRSRSWSR--SRSRSRRYSRSRSRGRRHSGGGS---RDGHRYSRSPARRGGYGPRR-- 467

Query: 408 NKARDRSRSRSPYKARDRSRSRSPNKARDCSRSRSPYKARDRSRSRSPNKARDHSRSRSP 467
              R RSRS S  + R   R    + +   SRSRS +     SRSRS  ++R HS S S 
Sbjct: 468 ---RSRSRSHSGDRYRRGGRGLRHHSS---SRSRSSWSLSP-SRSRSLTRSRSHSPSPSQ 520

Query: 468 NKARDRSRSRSPSKERDHSQLGSPSKERDHRRSRSPSKERQCRQSR-SSSKERDHRRSR- 525
           +++R RSRS+SPS         SP++E+  R + SP+   + +++  ++ KE    + + 
Sbjct: 521 SRSRSRSRSQSPSP--------SPAREKLTRPAASPAVGEKLKKTEPAAGKETGAAKPKL 572

Query: 526 SPSKERQRRQSRSPNKE--RDRSQSRSPSEEREH-RQSRSPS----------KERDRRRW 572
           +P ++ + R  ++ N++   D+  ++    ++EH RQ R             KER+RR  
Sbjct: 573 TPQEKLKLRMQKALNRQFKADKKAAQEKMIQQEHERQEREDELRAMARKIRMKERERREK 632

Query: 573 RSPSKERE-RRQSRS----------SSEERDHSRSRSPN 600
                ER+  RQSRS          SS  R  SRSRSP+
Sbjct: 633 EREEWERQYSRQSRSPSPRYSREYSSSRRRSRSRSRSPH 671



 Score =  115 bits (289), Expect = 1e-25
 Identities = 126/414 (30%), Positives = 191/414 (46%), Gaps = 52/414 (12%)

Query: 257 YSPTEMSSRVKSYNQASTRSR---PQSHSQSRSP-----RRSRSGSQKRTHSRVRSHSWK 308
           YS      + + + +   R R   P S+++  SP     +RS S S   + SR RS +  
Sbjct: 262 YSGRRSRRQRREFREKRLRGRKISPPSYARRDSPTYDPYKRSPSESSSESRSRSRSPTPG 321

Query: 309 RNHSRARSRTRKGILSQMGRHSQSRSHSKGKSQNQSRTPRRGRSHNWSRNPS-KERSHSH 367
           R   +    T  G   +    + + + + G +  +   P +       RN S + RS S 
Sbjct: 322 REE-KITFITSFGGSDEEAAAAAAAAAASGVTTGKPPAPPQPGGPAPGRNASARRRSSSS 380

Query: 368 SRSSSKERDHRGSSSPRKESGRSQSGSPNKQRDHSRSRSPNKARDRSRSRSPYKARDRSR 427
           S SSS  R     SS R  S   + G   +   H+RSRS + +R RSRSR   ++R R R
Sbjct: 381 SSSSSASRTSSSRSSSRSSSRSRRGGGYYRSGRHARSRSRSWSRSRSRSRRYSRSRSRGR 440

Query: 428 SRSPNKARDCSR-SRSPYKA-------RDRSRSRSPNKARDHSRS-RSPNKARDRSR-SR 477
             S   +RD  R SRSP +        R RSRS S ++ R   R  R  + +R RS  S 
Sbjct: 441 RHSGGGSRDGHRYSRSPARRGGYGPRRRSRSRSHSGDRYRRGGRGLRHHSSSRSRSSWSL 500

Query: 478 SPSKE----RDHSQLGSPSKERDHRRSR------SPSKERQCRQSRS------------- 514
           SPS+     R  S   SPS+ R   RSR      SP++E+  R + S             
Sbjct: 501 SPSRSRSLTRSRSHSPSPSQSRSRSRSRSQSPSPSPAREKLTRPAASPAVGEKLKKTEPA 560

Query: 515 SSKERDHRRSR-SPSKERQRRQSRSPNKE--RDRSQSRSPSEEREH-RQSRSPSKERDRR 570
           + KE    + + +P ++ + R  ++ N++   D+  ++    ++EH RQ R        R
Sbjct: 561 AGKETGAAKPKLTPQEKLKLRMQKALNRQFKADKKAAQEKMIQQEHERQEREDELRAMAR 620

Query: 571 RWRSPSKERERRQSRSSSEERDHSR-SRSPNKQSGYSRPRASSKEKAHSRSRTP 623
           + R   KERERR+      ER +SR SRSP+ +  YSR  +SS+ ++ SRSR+P
Sbjct: 621 KIR--MKERERREKEREEWERQYSRQSRSPSPR--YSREYSSSRRRSRSRSRSP 670



 Score =  102 bits (254), Expect = 1e-21
 Identities = 117/411 (28%), Positives = 172/411 (41%), Gaps = 57/411 (13%)

Query: 133 KRSPSRASTPGRIRTHGARPGMASRVRTPTSQQKGSRGKSYGRPRTSNRERSDSQPRNLS 192
           KRSPS +S+  R R+    PG   ++   T     S G S      +    + S      
Sbjct: 301 KRSPSESSSESRSRSRSPTPGREEKITFIT-----SFGGSDEEAAAAAAAAAASGVTTGK 355

Query: 193 KKSYRPPGGSGIGRSSELAVTPSTAKCQTPTGIPSKEKSDNPSPSSSRKVKSYGQMIIPS 252
             +   PGG   GR++      S++   +     S  +S + S S SR+   Y +    +
Sbjct: 356 PPAPPQPGGPAPGRNASARRRSSSSSSSSSASRTSSSRSSSRSSSRSRRGGGYYRSGRHA 415

Query: 253 REKSYSPTEMSSRVKSYNQASTRSRPQS-------HSQSRSPRRSRSGSQKRTHSRVRSH 305
           R +S S +   SR + Y+++ +R R  S       H  SRSP R R G   R  SR RSH
Sbjct: 416 RSRSRSWSRSRSRSRRYSRSRSRGRRHSGGGSRDGHRYSRSPAR-RGGYGPRRRSRSRSH 474

Query: 306 SWKRNHSRARSRTRKGILSQMGRHSQSRSHSK-GKSQNQSRTPRRGRSHNWSRNPSKERS 364
           S  R     R          +  HS SRS S    S ++SR+  R RSH  S +PS+ RS
Sbjct: 475 SGDRYRRGGRG---------LRHHSSSRSRSSWSLSPSRSRSLTRSRSH--SPSPSQSRS 523

Query: 365 HSHSRSSSKERDHRGSSSPRKESGRSQSGSPN-----KQRDHSRSRSPNKARDRSRSRSP 419
            S SRS S       S SP +E     + SP      K+ + +  +    A+ +   +  
Sbjct: 524 RSRSRSQSP------SPSPAREKLTRPAASPAVGEKLKKTEPAAGKETGAAKPKLTPQEK 577

Query: 420 YKARDRSRSRSPNKARDCSRSRSPYKARDRSRSRSPNKARDHSRSRSPNKARDRSRSRSP 479
            K R +       KA             D+  ++     ++H R    ++ R  +R +  
Sbjct: 578 LKLRMQKALNRQFKA-------------DKKAAQEKMIQQEHERQEREDELRAMAR-KIR 623

Query: 480 SKERDHSQLGSPSKERDH-RRSRSPSKERQCRQSR--SSSKERDHRRSRSP 527
            KER+  +      ER + R+SRSPS     R SR  SSS+ R   RSRSP
Sbjct: 624 MKERERREKEREEWERQYSRQSRSPSP----RYSREYSSSRRRSRSRSRSP 670



 Score = 99.8 bits (247), Expect = 8e-21
 Identities = 118/452 (26%), Positives = 183/452 (40%), Gaps = 74/452 (16%)

Query: 153 GMASRVRTPTSQQKGSRGKSYGRPRTSNRE--------RSDSQPRNLSKKSYRPPGG--- 201
           G  SR +    ++K  RG+    P  + R+        RS S+  + S+   R P     
Sbjct: 264 GRRSRRQRREFREKRLRGRKISPPSYARRDSPTYDPYKRSPSESSSESRSRSRSPTPGRE 323

Query: 202 ------SGIGRSSELAVTPSTAKCQTPTGIPSKEKSDNPSPSSSRKVKSYGQMIIPSREK 255
                 +  G S E A   + A   +  G+ + +    P P      ++       S   
Sbjct: 324 EKITFITSFGGSDEEAAAAAAAAAAS--GVTTGKPPAPPQPGGPAPGRNASARRRSSSSS 381

Query: 256 SYSPTEMSSRVKSYNQASTRSRPQS-------HSQSRSPRRSRSGSQKRTHSRVRSHSWK 308
           S S    +S  +S +++S+RSR          H++SRS   SRS S+ R +SR RS    
Sbjct: 382 SSSSASRTSSSRSSSRSSSRSRRGGGYYRSGRHARSRSRSWSRSRSRSRRYSRSRSRG-- 439

Query: 309 RNHSRARSRTRKGILSQMGRHSQSRSHSKGKSQNQSRTPRRGRSHNWSRNPSKERSHSHS 368
           R HS   SR                          SR+P R R     R  S+ RSHS  
Sbjct: 440 RRHSGGGSR---------------------DGHRYSRSPAR-RGGYGPRRRSRSRSHSGD 477

Query: 369 RSSSKERDHRGSSSPRKESGRSQSGSPNKQRDHSRSRSPNKARDRSRSRSPYKARDRSRS 428
           R     R  R  SS R  S  S S S ++    SRS SP+ ++ RSRSRS      RS+S
Sbjct: 478 RYRRGGRGLRHHSSSRSRSSWSLSPSRSRSLTRSRSHSPSPSQSRSRSRS------RSQS 531

Query: 429 RSPNKARD-CSRSRSPYKARDRSRSRSPNKARDHSRSRSPNKARDRSRSRSPSKERDHSQ 487
            SP+ AR+  +R  +     ++ +   P   ++   ++     +++ + R          
Sbjct: 532 PSPSPAREKLTRPAASPAVGEKLKKTEPAAGKETGAAKPKLTPQEKLKLRM--------- 582

Query: 488 LGSPSKERDHRRSRSPSKERQCRQSRSSSKERDHRRSRSPS---KERQRRQSRSPNKERD 544
               +  R  +  +  ++E+  +Q     +  D  R+ +     KER+RR+      ER 
Sbjct: 583 --QKALNRQFKADKKAAQEKMIQQEHERQEREDELRAMARKIRMKERERREKEREEWERQ 640

Query: 545 RS-QSRSPSEEREHRQSRSPSKERDRRRWRSP 575
            S QSRSPS    + +  S S+ R R R RSP
Sbjct: 641 YSRQSRSPSP--RYSREYSSSRRRSRSRSRSP 670



 Score = 92.8 bits (229), Expect = 1e-18
 Identities = 95/327 (29%), Positives = 138/327 (42%), Gaps = 22/327 (6%)

Query: 401 HSRSRSPNKA-----RDRSRSRSPYKARDRSRSRSP-NKARDCSRSRSPYKARDRSRSRS 454
           H+++    KA     R R + R   + R R R  SP + AR  S +  PYK     RS S
Sbjct: 251 HAKALEEEKAMYSGRRSRRQRREFREKRLRGRKISPPSYARRDSPTYDPYK-----RSPS 305

Query: 455 PNKARDHSRSRSPNKARDRSRSRSPS---KERDHSQLGSPSKERDHRRSRSPSKERQCRQ 511
            + +   SRSRSP   R+   +   S    + + +   + +        + P+  +    
Sbjct: 306 ESSSESRSRSRSPTPGREEKITFITSFGGSDEEAAAAAAAAAASGVTTGKPPAPPQPGGP 365

Query: 512 SRSSSKERDHRRSRSPSKERQRRQSRSPNKERDRSQSRSPS---EEREHRQSRSPSKERD 568
           +   +     R S S S     R S S +  R  S+SR          H +SRS S  R 
Sbjct: 366 APGRNASARRRSSSSSSSSSASRTSSSRSSSRSSSRSRRGGGYYRSGRHARSRSRSWSRS 425

Query: 569 RRRWRSPSKERERRQSRSSSEERD-HSRSRSPNKQSGYSRPRASSKEKAHSRSRTPSKEG 627
           R R R  S+ R R +  S    RD H  SRSP ++ GY  PR  S+ ++HS  R   + G
Sbjct: 426 RSRSRRYSRSRSRGRRHSGGGSRDGHRYSRSPARRGGYG-PRRRSRSRSHSGDR--YRRG 482

Query: 628 NHSQSRTSSKESDPSQSTVP-RSPDWKRSPTRTSSLSQNRTPSKTSSHSPSTFPSGGQTL 686
                  SS  S  S S  P RS    RS + + S SQ+R+ S++ S SPS  P+  +  
Sbjct: 483 GRGLRHHSSSRSRSSWSLSPSRSRSLTRSRSHSPSPSQSRSRSRSRSQSPSPSPAREKLT 542

Query: 687 SQDDSQADATTSKATLPGERSSSSSSK 713
               S A     K T P     + ++K
Sbjct: 543 RPAASPAVGEKLKKTEPAAGKETGAAK 569



 Score = 92.8 bits (229), Expect = 1e-18
 Identities = 111/349 (31%), Positives = 155/349 (44%), Gaps = 49/349 (14%)

Query: 295 QKRTHSRVRSHSWKRNHSRARSRTRKGILSQMGR--------HSQSRSHSKGKSQNQSRT 346
           +K  +S  RS   +R     R R RK       R        + +S S S  +S+++SR+
Sbjct: 258 EKAMYSGRRSRRQRREFREKRLRGRKISPPSYARRDSPTYDPYKRSPSESSSESRSRSRS 317

Query: 347 PRRGRSHNWSRNPSKERSHSHSRSSSKERDHRGSSSPRKESGRSQSGSPNKQRDHSRSRS 406
           P  GR    +   S   S   + +++      G ++  K     Q G P   R+ S    
Sbjct: 318 PTPGREEKITFITSFGGSDEEAAAAAAAAAASGVTTG-KPPAPPQPGGPAPGRNAS---- 372

Query: 407 PNKARDRSRSRSPYKARDRSRSRSPNKARDCSRSRSPYKARDRSRSRSPNKARDHSRSRS 466
              AR RS S S   +  R+ S S + +R  SRSR     R     RS   AR  SRS S
Sbjct: 373 ---ARRRSSSSSSSSSASRTSS-SRSSSRSSSRSR-----RGGGYYRSGRHARSRSRSWS 423

Query: 467 PNKARDRSRSRSPSKERDHSQLGSPSKERD-HRRSRSPSKERQCRQSRSSSKERDHRRSR 525
            +++R R  SRS S+ R HS  GS    RD HR SRSP++       R     R   RSR
Sbjct: 424 RSRSRSRRYSRSRSRGRRHSGGGS----RDGHRYSRSPAR-------RGGYGPRRRSRSR 472

Query: 526 SPSKERQRRQSRS---PNKERDRSQ-SRSPSEEREHRQSR----SPSKERDRRRWR---- 573
           S S +R RR  R     +  R RS  S SPS  R   +SR    SPS+ R R R R    
Sbjct: 473 SHSGDRYRRGGRGLRHHSSSRSRSSWSLSPSRSRSLTRSRSHSPSPSQSRSRSRSRSQSP 532

Query: 574 SPSKERERRQSRSSSE---ERDHSRSRSPNKQSGYSRPRASSKEKAHSR 619
           SPS  RE+    ++S    E+      +  K++G ++P+ + +EK   R
Sbjct: 533 SPSPAREKLTRPAASPAVGEKLKKTEPAAGKETGAAKPKLTPQEKLKLR 581



 Score = 91.3 bits (225), Expect = 3e-18
 Identities = 99/381 (25%), Positives = 152/381 (39%), Gaps = 31/381 (8%)

Query: 3   SPKRSSKPSMSLAPSGSSMPTADPKPPASLKSTKSATPNRSLVPTKPATSRNSVMSPSSS 62
           +P R  K +   +  GS    A     A+     +  P     P  PA  RN+     SS
Sbjct: 319 TPGREEKITFITSFGGSDEEAAAAAAAAAASGVTTGKPPAPPQPGGPAPGRNASARRRSS 378

Query: 63  KSTKSTSTKRAPSNRPSSRSRVRSKARTPSRVSTDTRTSKASKASDVRCHQRRGTHSRGR 122
            S+ S+S  R  S+R SSRS   S++R         R +++   S  R   R   +SR R
Sbjct: 379 SSSSSSSASRTSSSRSSSRS--SSRSRRGGGYYRSGRHARSRSRSWSRSRSRSRRYSRSR 436

Query: 123 TPGRRGSRSSKRSPSRAS-TPGRIRTHGARPGMASRVRTPTSQQKGSRGKSYGRPRTSNR 181
           + GRR S    R   R S +P R   +G R    SR  +    ++G RG           
Sbjct: 437 SRGRRHSGGGSRDGHRYSRSPARRGGYGPRRRSRSRSHSGDRYRRGGRGL---------- 486

Query: 182 ERSDSQPRNLSKKSYRPPGGSGIGRSSELAVTPSTAKCQTPTGIPSKEKSDNPSPSSSRK 241
            R  S  R+ S  S  P     + RS   + +PS ++ +      S+ +S +PSPS +R+
Sbjct: 487 -RHHSSSRSRSSWSLSPSRSRSLTRSRSHSPSPSQSRSR------SRSRSQSPSPSPARE 539

Query: 242 VKSYGQMIIPSREKSYSPTEMSSRVKSYNQASTRSRPQSHSQSRSPR---RSRSGSQKRT 298
            K       P+  +    TE ++  K    A  +  PQ   + R  +   R     +K  
Sbjct: 540 -KLTRPAASPAVGEKLKKTEPAAG-KETGAAKPKLTPQEKLKLRMQKALNRQFKADKKAA 597

Query: 299 HSRV--RSHSWKRNHSRARSRTRKGILSQMGRHSQSRSHSKGKSQNQSRTPRRGRSHNWS 356
             ++  + H  +      R+  RK  + +  R  + R   + +   QSR+P    S  +S
Sbjct: 598 QEKMIQQEHERQEREDELRAMARKIRMKERERREKEREEWERQYSRQSRSP----SPRYS 653

Query: 357 RNPSKERSHSHSRSSSKERDH 377
           R  S  R  S SRS S    H
Sbjct: 654 REYSSSRRRSRSRSRSPHYRH 674



 Score = 82.4 bits (202), Expect = 1e-15
 Identities = 118/432 (27%), Positives = 174/432 (40%), Gaps = 85/432 (19%)

Query: 71  KRAPSNRPSSRSRVRSKARTPSRVSTDTRTSKASKASDVRCHQRRGTHSRGRTPGRRGSR 130
           KR+PS   SS SR RS++ TP R    T  +    + +          + G T G+    
Sbjct: 301 KRSPSES-SSESRSRSRSPTPGREEKITFITSFGGSDEEAAAAAAAAAASGVTTGK---- 355

Query: 131 SSKRSPSRASTPGRIRTHGARPGMASRVRTPTSQQKGSRGKSYGRPRTSNRERSDSQPRN 190
                P     PG     G  PG  +  R  +S    S   S    RTS+        R+
Sbjct: 356 -----PPAPPQPG-----GPAPGRNASARRRSSSSSSSSSAS----RTSS-------SRS 394

Query: 191 LSKKSYRPPGGSGIGRSSELAVTP----STAKCQTPTGIPSKEKSDNPSPSSSRKVKSYG 246
            S+ S R   G G  RS   A +     S ++ ++     S+ +    S   SR    Y 
Sbjct: 395 SSRSSSRSRRGGGYYRSGRHARSRSRSWSRSRSRSRRYSRSRSRGRRHSGGGSRDGHRYS 454

Query: 247 QMIIPSREKSYSPTEMSSRVKSYNQASTRSRPQSHSQSRSPRRSRSGSQKRTHSRVRSHS 306
           +   P+R   Y P   S             R +SHS  R  RR   G +  + SR RS S
Sbjct: 455 RS--PARRGGYGPRRRS-------------RSRSHSGDRY-RRGGRGLRHHSSSRSRS-S 497

Query: 307 WKRNHSRARSRTRKGILSQMGRHSQSRSHSKGKSQNQSRTPRRGRSHNWSRNPS-KERSH 365
           W  + SR+RS TR    S     SQSRS S+ +SQ+ S +P R +    + +P+  E+  
Sbjct: 498 WSLSPSRSRSLTRS--RSHSPSPSQSRSRSRSRSQSPSPSPAREKLTRPAASPAVGEKLK 555

Query: 366 SHSRSSSKERDHRGSSSP----------RKESGRSQSGSPNK--------QRDHSRSRSP 407
               ++ KE    G++ P          R +   ++    +K        Q++H R    
Sbjct: 556 KTEPAAGKE---TGAAKPKLTPQEKLKLRMQKALNRQFKADKKAAQEKMIQQEHERQERE 612

Query: 408 NKARDRSRSRSPYKARDRSRSRSPNKARDCSRSRSPYKARDRSRSRSPNKARDHSRSRSP 467
           ++ R  +R     K R + R R   +  +  R  S      +SRS SP  +R++S SR  
Sbjct: 613 DELRAMAR-----KIRMKERERREKEREEWERQYS-----RQSRSPSPRYSREYSSSR-- 660

Query: 468 NKARDRSRSRSP 479
              R RSRSRSP
Sbjct: 661 --RRSRSRSRSP 670



 Score = 78.6 bits (192), Expect = 2e-14
 Identities = 83/290 (28%), Positives = 114/290 (39%), Gaps = 34/290 (11%)

Query: 370 SSSKERDHRGSSSPRKESGRSQSGSPNKQRD------HSRSRSPNKARDRSRSRSPYKAR 423
           S  + R  R     ++  GR  S     +RD      + RS S + +  RSRSRSP   R
Sbjct: 263 SGRRSRRQRREFREKRLRGRKISPPSYARRDSPTYDPYKRSPSESSSESRSRSRSPTPGR 322

Query: 424 DR------SRSRSPNKARDCSRSRSPYKARDRSRSRSPNKARDHSRSRSPNKARDRSRSR 477
           +       S   S  +A   + + +            P          +  + R  S S 
Sbjct: 323 EEKITFITSFGGSDEEAAAAAAAAAASGVTTGKPPAPPQPGGPAPGRNASARRRSSSSSS 382

Query: 478 SPSKERDHSQLGSPSKERDHRRSRSPSKERQCRQSRSSSKERDHRRSRSPSKERQRRQSR 537
           S S  R  S   S       RR     +  +  +SRS S  R   RSR  S+ R R +  
Sbjct: 383 SSSASRTSSSRSSSRSSSRSRRGGGYYRSGRHARSRSRSWSRSRSRSRRYSRSRSRGRRH 442

Query: 538 SPNKERDRSQSRSPSEEREHRQSRSPSKE-----RDRRRWRSPSKERERRQSRSSSEERD 592
           S    RD            HR SRSP++      R R R RS S +R RR  R     R 
Sbjct: 443 SGGGSRD-----------GHRYSRSPARRGGYGPRRRSRSRSHSGDRYRRGGRGL---RH 488

Query: 593 HSRSRSPNKQSGYSRPRASSKEKAHSRSRTPSKEGNHSQSRTSSKESDPS 642
           HS SRS   +S +S   + S+    SRS +PS   + S+SR+ S+   PS
Sbjct: 489 HSSSRS---RSSWSLSPSRSRSLTRSRSHSPSPSQSRSRSRSRSQSPSPS 535


>gi|38146107 arginine/serine-rich coiled-coil 2 isoform a [Homo
           sapiens]
          Length = 434

 Score =  110 bits (275), Expect = 5e-24
 Identities = 88/268 (32%), Positives = 132/268 (49%), Gaps = 12/268 (4%)

Query: 272 ASTRSRPQSHSQSRSPRRSRSGSQKRTHSRVRSHSWKRNHSRARSRTRKGILSQMGRHSQ 331
           AS   R     +  SP R +   Q       R+     + SR+RSR RK      GR  +
Sbjct: 3   ASDTERDGLAPEKTSPDRDKKKEQSEVSVSPRASKHHYSRSRSRSRERKRKSDNEGRKHR 62

Query: 332 SRSHSKGKSQNQSRTPRRGRSHNWSRNPSKERSHSHSR---SSSKERDHRGSSSPRKES- 387
           SRS SK   +++S+  +  + H    +  KE S    R   +SS+  + R     RK S 
Sbjct: 63  SRSRSKEGRRHESKD-KSSKKHKSEEHNDKEHSSDKGRERLNSSENGEDRHKRKERKSSR 121

Query: 388 GRSQSGSPNKQRDHSRSRSPNKARDRSRSRSPYKARDRSRSRSPNKARDCSRSRSPYKAR 447
           GRS S S +++R H RSRS  + + RSRSR   K+R RSR R  +++R   R R   + R
Sbjct: 122 GRSHSRSRSRERRH-RSRSRERKKSRSRSRERKKSRSRSRERKKSRSRSRERKR---RIR 177

Query: 448 DRSRSRSPNKARDHSRSRSPNKARDR-SRSRSPSK-ERDHSQLGSPSKERDHRRSRSPSK 505
            RSRSRS ++ R  SRSR+ +++RDR  R   P +  R  S+  SP   R  R +   ++
Sbjct: 178 SRSRSRSRHRHRTRSRSRTRSRSRDRKKRIEKPRRFSRSLSRTPSPPPFRG-RNTAMDAQ 236

Query: 506 ERQCRQSRSSSKERDHRRSRSPSKERQR 533
           E   R+   + K ++ R      K++Q+
Sbjct: 237 EALARRLERAKKLQEQREKEMVEKQKQQ 264



 Score =  107 bits (268), Expect = 3e-23
 Identities = 87/264 (32%), Positives = 130/264 (49%), Gaps = 17/264 (6%)

Query: 370 SSSKERDHRG--SSSPRKESGRSQSG---SPNKQRDH-SRSRSPNKARDRSRSRSPYKAR 423
           +S  ERD      +SP ++  + QS    SP   + H SRSRS ++ R R       K R
Sbjct: 3   ASDTERDGLAPEKTSPDRDKKKEQSEVSVSPRASKHHYSRSRSRSRERKRKSDNEGRKHR 62

Query: 424 DRSRSRSPNKARDCSRSRSPYKARDRS-RSRSPNKARDHSRSRSPNKARDRSRSRSPSKE 482
            RSRS+   +     +S   +K+ + + +  S +K R+   S    + R + + R  S+ 
Sbjct: 63  SRSRSKEGRRHESKDKSSKKHKSEEHNDKEHSSDKGRERLNSSENGEDRHKRKERKSSRG 122

Query: 483 RDHSQLGSPSKERDHRRSRSPSKERQCRQSRSSSKERDHRRSRSPSKERQRRQSRSPNKE 542
           R HS+  S S+ER HR     S+ R+ ++SRS S+ER  ++SRS S+ER++ +SRS  ++
Sbjct: 123 RSHSR--SRSRERRHR-----SRSRERKKSRSRSRER--KKSRSRSRERKKSRSRSRERK 173

Query: 543 RDRSQSRSPSEEREHRQSRSPSKERDRRRWRSPSKERERRQSRSSSEERDHSRSRSPNKQ 602
           R R +SRS S  R   ++RS S+ R R R R    E+ RR SRS S        R  N  
Sbjct: 174 R-RIRSRSRSRSRHRHRTRSRSRTRSRSRDRKKRIEKPRRFSRSLSRTPSPPPFRGRNTA 232

Query: 603 SGYSRPRASSKEKAHSRSRTPSKE 626
                  A   E+A        KE
Sbjct: 233 MDAQEALARRLERAKKLQEQREKE 256



 Score =  103 bits (258), Expect = 4e-22
 Identities = 80/259 (30%), Positives = 125/259 (48%), Gaps = 17/259 (6%)

Query: 332 SRSHSKGKSQNQSRTPRRGRSHNWSRNPSKERSHSHSRSSSKERDHRG---SSSPRKESG 388
           S    K K Q++     R   H++SR+ S+ R     +S ++ R HR    S   R+   
Sbjct: 17  SPDRDKKKEQSEVSVSPRASKHHYSRSRSRSRERKR-KSDNEGRKHRSRSRSKEGRRHES 75

Query: 389 RSQSGSPNKQRDHS-RSRSPNKARDRSRSRSPYKARDRSRSRSPNKARDCSRSRSPYKAR 447
           + +S   +K  +H+ +  S +K R+R  S    + R + + R  ++ R  SRSRS  + R
Sbjct: 76  KDKSSKKHKSEEHNDKEHSSDKGRERLNSSENGEDRHKRKERKSSRGRSHSRSRSRER-R 134

Query: 448 DRSRSRSPNKARDHSRSRSPNKARDRSRSRSPSKERDHSQLGSPSKERDHR-RSRSPSKE 506
            RSRSR   K+R  SRSR   K+R RSR R  S+ R        S+ER  R RSRS S+ 
Sbjct: 135 HRSRSRERKKSR--SRSRERKKSRSRSRERKKSRSR--------SRERKRRIRSRSRSRS 184

Query: 507 RQCRQSRSSSKERDHRRSRSPSKERQRRQSRSPNKERDRSQSRSPSEEREHRQSRSPSKE 566
           R   ++RS S+ R   R R    E+ RR SRS ++       R  +   + +++ +   E
Sbjct: 185 RHRHRTRSRSRTRSRSRDRKKRIEKPRRFSRSLSRTPSPPPFRGRNTAMDAQEALARRLE 244

Query: 567 RDRRRWRSPSKERERRQSR 585
           R ++      KE   +Q +
Sbjct: 245 RAKKLQEQREKEMVEKQKQ 263



 Score = 94.0 bits (232), Expect = 4e-19
 Identities = 73/228 (32%), Positives = 109/228 (47%), Gaps = 14/228 (6%)

Query: 474 SRSRSPSKERDHSQLGSPSKERDHRRSRSPSKER------QCRQSRSSSKERDHRRSRSP 527
           S  R   KE+    +   + +  + RSRS S+ER      + R+ RS S+ ++ RR  S 
Sbjct: 17  SPDRDKKKEQSEVSVSPRASKHHYSRSRSRSRERKRKSDNEGRKHRSRSRSKEGRRHESK 76

Query: 528 SKERQRRQSRSPN-KERDRSQSRSPSEEREHRQSRSPSKERDRRRWRSPSKERER-RQSR 585
            K  ++ +S   N KE    + R      E+ + R   KER   R RS S+ R R R+ R
Sbjct: 77  DKSSKKHKSEEHNDKEHSSDKGRERLNSSENGEDRHKRKERKSSRGRSHSRSRSRERRHR 136

Query: 586 SSSEERDHSRSRSPNKQSGYSRPRASSKEKAHSRSRTPSKEGNHSQSRTSSKESDPSQST 645
           S S ER  SRSRS  ++   SR R   K ++ SR R   K    S+SR+ S+    ++S 
Sbjct: 137 SRSRERKKSRSRSRERKKSRSRSRERKKSRSRSRER---KRRIRSRSRSRSRHRHRTRS- 192

Query: 646 VPRSPDWKRSPTRTSSLSQNRTPSKTSSHSPSTFPSGGQTLSQDDSQA 693
             RS    RS  R   + + R  S++ S +PS  P  G+  + D  +A
Sbjct: 193 --RSRTRSRSRDRKKRIEKPRRFSRSLSRTPSPPPFRGRNTAMDAQEA 238



 Score = 75.9 bits (185), Expect = 1e-13
 Identities = 77/287 (26%), Positives = 123/287 (42%), Gaps = 41/287 (14%)

Query: 151 RPGMASRVRTPTSQQKGSRGKSYGRPRTSNRERSDSQPRNLSKKSYRPPGGSGIGRSSEL 210
           R G+A    +P   +K  + +    PR S    S S+ R+  +K           R S+ 
Sbjct: 8   RDGLAPEKTSPDRDKKKEQSEVSVSPRASKHHYSRSRSRSRERK-----------RKSDN 56

Query: 211 AVTPSTAKCQTPTGIPSKEKSDNPSPSSSRKVKSYGQMIIPSREKSYSPTEMSSRVKSYN 270
                 ++ ++  G   + K       SS+K KS         +K +S  +   R+ S  
Sbjct: 57  EGRKHRSRSRSKEGRRHESKD-----KSSKKHKSE-----EHNDKEHSSDKGRERLNSSE 106

Query: 271 QASTRSRPQSHSQSRSPRRSRSGSQKRTHSRVRSHSWKRNHSRARSRTRKGILSQMGRHS 330
               R + +    SR    SRS S++R H   RS S +R  SR+RSR RK         S
Sbjct: 107 NGEDRHKRKERKSSRGRSHSRSRSRERRH---RSRSRERKKSRSRSRERK--------KS 155

Query: 331 QSRSHSKGKSQNQSR-TPRRGRSHNWSRNPSKERSHSHSRSSSKERDHRGSSSPRKESGR 389
           +SRS  + KS+++SR   RR RS + SR+  + R+ S SR+ S+ RD +      +   R
Sbjct: 156 RSRSRERKKSRSRSRERKRRIRSRSRSRSRHRHRTRSRSRTRSRSRDRKKRIEKPRRFSR 215

Query: 390 SQSGSPNKQRDHSRSRSPNKARDRSRSRSPYKARDRSRSRSPNKARD 436
           S S +P        S  P + R+ +       AR   R++   + R+
Sbjct: 216 SLSRTP--------SPPPFRGRNTAMDAQEALARRLERAKKLQEQRE 254



 Score = 60.5 bits (145), Expect = 5e-09
 Identities = 64/253 (25%), Positives = 106/253 (41%), Gaps = 24/253 (9%)

Query: 130 RSSKRSPSRAS-TPGRIRTHGARPGMASRVRTPTSQQKGSRGKSYGRPRTSNRERSDSQP 188
           R  K+  S  S +P   + H +R    SR R   S  +G + +S  R +   R  S    
Sbjct: 20  RDKKKEQSEVSVSPRASKHHYSRSRSRSRERKRKSDNEGRKHRSRSRSKEGRRHES---- 75

Query: 189 RNLSKKSYRPPGGSGIGRSSELAVTPSTAKCQTPTGIPSKEKSDNPSPSSSRKVKSYGQM 248
           ++ S K ++    +    SS+              G      S+N      RK +   + 
Sbjct: 76  KDKSSKKHKSEEHNDKEHSSD-------------KGRERLNSSENGEDRHKRKERKSSRG 122

Query: 249 IIPSREKSYSPTEMS-SRVKSYNQASTRSRPQSHSQSRSPRRSRSGSQKRTHSRVRSHSW 307
              SR +S      S SR +  +++ +R R +S S+SR  ++SRS S++R   R+RS S 
Sbjct: 123 RSHSRSRSRERRHRSRSRERKKSRSRSRERKKSRSRSRERKKSRSRSRERKR-RIRSRSR 181

Query: 308 KRNHSRA----RSRTRKGILSQMGRHSQSRSHSKGKSQNQSRTPRRGRSHNWSRNPSKER 363
            R+  R     RSRTR     +  R  + R  S+  S+  S  P RGR+       +  R
Sbjct: 182 SRSRHRHRTRSRSRTRSRSRDRKKRIEKPRRFSRSLSRTPSPPPFRGRNTAMDAQEALAR 241

Query: 364 SHSHSRSSSKERD 376
               ++   ++R+
Sbjct: 242 RLERAKKLQEQRE 254



 Score = 47.0 bits (110), Expect = 6e-05
 Identities = 44/200 (22%), Positives = 78/200 (39%), Gaps = 5/200 (2%)

Query: 5   KRSSKPSMSLAPSGSSMPTADPKPPASLKSTKSATPNRS-LVPTKPATSRNSVMSPSSSK 63
           K+  +  +S++P  S    +  +  +  +  KS    R     ++    R       SSK
Sbjct: 22  KKKEQSEVSVSPRASKHHYSRSRSRSRERKRKSDNEGRKHRSRSRSKEGRRHESKDKSSK 81

Query: 64  STKSTSTKRAPSNRPSSRSRVRSKARTPSRVSTDTRTSKASKASDVRCHQRRGTHSRGRT 123
             KS        +    R R+ S      R     R S   ++      + R   SR R 
Sbjct: 82  KHKSEEHNDKEHSSDKGRERLNSSENGEDRHKRKERKSSRGRSHSRSRSRERRHRSRSRE 141

Query: 124 PGRRGSRSSKRSPSRAST----PGRIRTHGARPGMASRVRTPTSQQKGSRGKSYGRPRTS 179
             +  SRS +R  SR+ +      R R+   +  + SR R+ +  +  +R +S  R R+ 
Sbjct: 142 RKKSRSRSRERKKSRSRSRERKKSRSRSRERKRRIRSRSRSRSRHRHRTRSRSRTRSRSR 201

Query: 180 NRERSDSQPRNLSKKSYRPP 199
           +R++   +PR  S+   R P
Sbjct: 202 DRKKRIEKPRRFSRSLSRTP 221



 Score = 43.1 bits (100), Expect = 9e-04
 Identities = 41/150 (27%), Positives = 59/150 (39%), Gaps = 15/150 (10%)

Query: 32  LKSTKSATPNRSLVPTKPATSRNSVMSPSSSKSTKSTSTKRAPS---NRPSSRSRVRSKA 88
           L S+++          K +  R+   S S  +  +S S +R  S   +R   +SR RS+ 
Sbjct: 102 LNSSENGEDRHKRKERKSSRGRSHSRSRSRERRHRSRSRERKKSRSRSRERKKSRSRSRE 161

Query: 89  RTPSRVSTDTRTSKASKASDVRCHQRRGTHSRGRTPGR------------RGSRSSKRSP 136
           R  SR  +  R  +    S  R   R  T SR RT  R            R SRS  R+P
Sbjct: 162 RKKSRSRSRERKRRIRSRSRSRSRHRHRTRSRSRTRSRSRDRKKRIEKPRRFSRSLSRTP 221

Query: 137 SRASTPGRIRTHGARPGMASRVRTPTSQQK 166
           S     GR     A+  +A R+      Q+
Sbjct: 222 SPPPFRGRNTAMDAQEALARRLERAKKLQE 251


>gi|55741709 RNA binding motif protein 25 [Homo sapiens]
          Length = 843

 Score =  108 bits (271), Expect = 1e-23
 Identities = 71/265 (26%), Positives = 121/265 (45%), Gaps = 7/265 (2%)

Query: 368 SRSSSKERD-HRG--SSSPRKESGRSQSGSPNKQRDHSRSRSPNKARDRSRSRSPYKARD 424
           SR  SK RD H+       +KE  R +     ++R+  R R   + R+R R R   + R+
Sbjct: 278 SREISKFRDTHKKLEEEKGKKEKERQEIEKERRERERERERERER-RERERERERERERE 336

Query: 425 RSRSRSPNKARDCSRSRSPYKARDRSRSRSPNKARDHSRSRSPNKARDRSRSRSPSKERD 484
           + + R   + RD  R R+  + RDR R R  ++ R+ S  R+ +++R R +SR   +ER+
Sbjct: 337 KEKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERERE 396

Query: 485 HSQLGSPSKERDHRRSRSPSKERQCRQSRSSSKERDHRRSRSPSKERQRRQSRSPNKERD 544
             +     +ER+  R R   +ER+  + R   K+RD       + ER++ + +   KE  
Sbjct: 397 REREREREREREREREREREREREREREREKDKKRDREEDEEDAYERRKLERKLREKEAA 456

Query: 545 RSQSRSPSEEREHRQSRSPSKERDRRRWRSPSKERERRQSRSSSEERDHSRSRSPNKQSG 604
             +     E RE +++R   KE +R   R     +E ++ +   E+ D  R      +  
Sbjct: 457 YQERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGS 516

Query: 605 YSRPRASSKEK---AHSRSRTPSKE 626
             + R   +EK   A  R R   KE
Sbjct: 517 ALQKRLRDREKEMEADERDRKREKE 541



 Score =  104 bits (260), Expect = 2e-22
 Identities = 83/378 (21%), Positives = 147/378 (38%), Gaps = 45/378 (11%)

Query: 332 SRSHSKGKSQNQSRTPRRGRSHNWSRNPSKERSHSHSRSSSKERDHRGSSSPRKESGRSQ 391
           SR  SK +  ++     +G+     +   KER     R   +ER+ R     R+      
Sbjct: 278 SREISKFRDTHKKLEEEKGKKEKERQEIEKER-RERERERERERERRERERERERE---- 332

Query: 392 SGSPNKQRDHSRSRSPNKARDRSRSRSPYKARDRSRSRSPNKARDCSRSRSPYKARDRSR 451
                ++R+  + R   + RDR R R+  + RDR R R  ++ R+ S  R+  ++R R +
Sbjct: 333 -----REREKEKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREK 387

Query: 452 SRSPNKARDHSRSRSPNKARDRSRSRSPSKERDHSQLGSPSKERDHRRSRSPSKERQCRQ 511
           SR   + R+  R R   + R+R R R   +ER+  +     K+RD       + ER+  +
Sbjct: 388 SRDREREREREREREREREREREREREREREREREREREKDKKRDREEDEEDAYERRKLE 447

Query: 512 SRSSSKERDHRRSRSPSKERQRRQSRSPNKERDRSQSRSPSEEREHRQSRSPSKERD--- 568
            +   KE  ++      + R+R+++R   KE +R + R     +E ++ +   ++ D   
Sbjct: 448 RKLREKEAAYQERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDYDDDR 507

Query: 569 -------------RRRWRSPSKERERRQSRSSSEERDHSRSR-------SPNKQSGYSRP 608
                        R R R    E + R  +   EE +  R R        P+ +      
Sbjct: 508 DDPKYYRGSALQKRLRDREKEMEADERDRKREKEELEEIRQRLLAEGHPDPDAELQRMEQ 567

Query: 609 RASSKEKAHSRSRTPSKEGNHSQSRTSSKESDPSQSTVPRSPDWK----------RSPTR 658
            A  + +   +    S+E    +     K  +P +      P+ K           S   
Sbjct: 568 EAERRRQPQIKQEPESEEEEEEKQEKEEKREEPMEE--EEEPEQKPCLKPTLRPISSAPS 625

Query: 659 TSSLSQNRTPSKTSSHSP 676
            SS S N TP+     SP
Sbjct: 626 VSSASGNATPNTPGDESP 643



 Score = 94.4 bits (233), Expect = 3e-19
 Identities = 92/431 (21%), Positives = 159/431 (36%), Gaps = 39/431 (9%)

Query: 296 KRTHSRVRSHSWKRNHSRARSRTRKGILSQMGRHSQSRSHSKGKSQNQSRTPRRGRSHNW 355
           K+   R      +R   R R R R+       R  + R   + + + + +   R R  + 
Sbjct: 297 KKEKERQEIEKERRERERERERERE-------RREREREREREREREKEKERERERERDR 349

Query: 356 SRNPSKERSHSHSRSSSKERDHRGSSSPRKESGRSQSGSPNKQRDHSRSRSPNKARDRSR 415
            R+ +KER     R   ++RD   SS   K+  RS+  S +++R+  R R   + R+R R
Sbjct: 350 DRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERERERERERERERERER 409

Query: 416 SRSPYKARDRSRSRSPNKARDCSRSRSPYKARDRSR-------------SRSPN-KARDH 461
            R   + R+R R R   K +   R      A +R +              R  N + R+ 
Sbjct: 410 EREREREREREREREREKDKKRDREEDEEDAYERRKLERKLREKEAAYQERLKNWEIRER 469

Query: 462 SRSRSPNKARDRSRSRSPSKERDHSQLGSPSKERD-------HRRSRSPSKERQCRQSRS 514
            ++R   K  +R   R     ++  +L    ++ D       + R  +  K  + R+   
Sbjct: 470 KKTREYEKEAEREEERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQKRLRDREKEM 529

Query: 515 SSKERDHRRSRSPSKERQRRQSRSPNKERDRSQSRSPSEEREHRQSR-SPSKERDRRRWR 573
            + ERD +R +   +E ++R     + + D    R   E    RQ +     E +     
Sbjct: 530 EADERDRKREKEELEEIRQRLLAEGHPDPDAELQRMEQEAERRRQPQIKQEPESEEEEEE 589

Query: 574 SPSKERERRQSRSSSEERDHSRSRSPNKQSGYSRPRASSKEKAHSRSRTPSKEGNHSQ-S 632
              KE +R +     EE +      P  +   S P  SS     S + TP+  G+ S   
Sbjct: 590 KQEKEEKREEPMEEEEEPEQKPCLKPTLRPISSAPSVSSA----SGNATPNTPGDESPCG 645

Query: 633 RTSSKESDPSQSTVPRSPDWKRSPTRTS-SLSQNRTPSKTSSHSPSTFPSGGQTLSQDDS 691
                E+ P Q    + P+  R     S  L  + +P + +S      P        +D 
Sbjct: 646 IIIPHENSPDQ----QQPEEHRPKIGLSLKLGASNSPGQPNSVKRKKLPVDSVFNKFEDE 701

Query: 692 QADATTSKATL 702
            +D    K  L
Sbjct: 702 DSDDVPRKRKL 712



 Score = 73.2 bits (178), Expect = 8e-13
 Identities = 68/336 (20%), Positives = 118/336 (35%), Gaps = 32/336 (9%)

Query: 265 RVKSYNQASTRSRPQSHSQSRSPRRSRSGSQKRTHSRVRSHSWKRNHSRARSRTRKGILS 324
           R +   +   R R +   + R+  R R   ++R   R R  S  RN  R+RSR +     
Sbjct: 333 REREKEKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREK----- 387

Query: 325 QMGRHSQSRSHSKGKSQNQSRTPRRGRSHNWSRNPSKERSHSHSRSSSKERDHRGSSSPR 384
                  SR   + + + + R   R R     R   +ER     R   K+RD        
Sbjct: 388 -------SRDREREREREREREREREREREREREREREREREREREKDKKRDREEDEEDA 440

Query: 385 KESGRSQSGSPNKQRDHSRSRSPNKARDRSRSRSPYKARDRSRSRSPNKARDCSRSRSPY 444
            E  + +     K+  +       + R+R ++R   K  +R   R    A++  R +   
Sbjct: 441 YERRKLERKLREKEAAYQERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFL 500

Query: 445 KARDRSRSRSPNKARDHSRSRSPNKARDRSRSRSPSKERDHSQLGSPSKERDHRRSRSPS 504
           +  D          RD  +    +  + R R R    E D         ERD +R +   
Sbjct: 501 EDYDDD--------RDDPKYYRGSALQKRLRDREKEMEAD---------ERDRKREKEEL 543

Query: 505 KERQCRQSRSSSKERDHRRSRSPSKERQRRQSRSPNKERDRSQSRSPSEEREHRQSRSPS 564
           +E + R       + D    R   +  +RRQ   P  +++        E++E  + R   
Sbjct: 544 EEIRQRLLAEGHPDPDAELQRMEQEAERRRQ---PQIKQEPESEEEEEEKQEKEEKREEP 600

Query: 565 KERDRRRWRSPSKERERRQSRSSSEERDHSRSRSPN 600
            E +    + P  +   R   S+      S + +PN
Sbjct: 601 MEEEEEPEQKPCLKPTLRPISSAPSVSSASGNATPN 636



 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 43/175 (24%), Positives = 73/175 (41%), Gaps = 22/175 (12%)

Query: 486 SQLGSPSKERD-HRRSRSPSKERQC-----------------RQSRSSSKERDHRR--SR 525
           S+L +PS+E D H R +   K+                        +   E D R   SR
Sbjct: 220 SELNAPSQESDSHPRKKKKEKKEDIFRRFPVAPLIPYPLITKEDINAIEMEEDKRDLISR 279

Query: 526 SPSKERQRRQSRSPNKERDRSQSRSPSEEREHRQSRSPSKERDRRRWRSPSKERERRQSR 585
             SK R   +     K +   + +   +ER  R+ R   +ER+RR  R   +ERER + +
Sbjct: 280 EISKFRDTHKKLEEEKGKKEKERQEIEKERRERE-RERERERERRE-REREREREREREK 337

Query: 586 SSSEERDHSRSRSPNKQSGYSRPRASSKEKAHSRSRTPSKEGNHSQSRTSSKESD 640
               ER+  R R  ++     R R   +++   R R+  +  + S+SR  S++ +
Sbjct: 338 EKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRE 392


>gi|21040326 SON DNA-binding protein isoform F [Homo sapiens]
          Length = 2426

 Score =  108 bits (270), Expect = 2e-23
 Identities = 123/460 (26%), Positives = 199/460 (43%), Gaps = 71/460 (15%)

Query: 221  TPTGIPSKEKSDNPSPSSSRKVKSYGQMIIPSREKSYSPTE-MSSRVKSYNQASTRSRPQ 279
            T   +P KE     +   S K  S G+  +P   K   P    S+ ++  N+A    RP 
Sbjct: 1679 TEEPLPVKESDQTLAALLSPKESSGGEKEVPPPPKETLPDSGFSANIEDINEADL-VRPL 1737

Query: 280  SHSQSRSPRRSRSGSQKRTHSRVRSHSWKRNHSRARSRTRKGILSQMGRHSQSRSHSKGK 339
                       R+G        +       +  R RS     + S   R S+S S  K  
Sbjct: 1738 LPKDMERLTSLRAG--------IEGPLLASDVGRDRSAASPVVSSMPERASESSSEEKDD 1789

Query: 340  SQNQSRTPRRGRSHNWSRNPSKERSHSHSRSSSKERDHRGSSSPRKESGRSQSGSPNKQR 399
             +   +              + E+S  +      E++ +  SS R  S RS+S     ++
Sbjct: 1790 YEIFVKV-----------KDTHEKSKKNKNRDKGEKEKKRDSSLRSRSKRSKSSEHKSRK 1838

Query: 400  DHSRSRSPNKARDRSRSRSPYKARDRSRSRSPNKARDCSRSRSPYKARDRSRSRSPNKAR 459
              S SRS  +AR RS     ++++ RSRSRS  + R          +R RS+SR      
Sbjct: 1839 RTSESRS--RARKRSSKSKSHRSQTRSRSRSRRRRRS---------SRSRSKSRGRRSVS 1887

Query: 460  DHSRSRSP-NKARDRSRSRSPSKERDHSQLGSPSKERDHRRSRSPSKERQCRQSRSSSKE 518
               R RSP ++++ R R R  S  RD+ +          RRSRS +  R+ R+SRS  + 
Sbjct: 1888 KEKRKRSPKHRSKSRERKRKRSSSRDNRKTVRARSRTPSRRSRSHTPSRR-RRSRSVGRR 1946

Query: 519  RDH-----RRSRSPSKERQ--RRQSRSPNKERDRSQSRSPSEEREHRQSRSPSKERDRRR 571
            R       RRSR+PS+  +   R+SR+P++     +SR+PS     R+SR+PS     RR
Sbjct: 1947 RSFSISPSRRSRTPSRRSRTPSRRSRTPSR-----RSRTPS-----RRSRTPS-----RR 1991

Query: 572  WRSPSKERERRQSRSSSEERDHS-------RSRSPNKQSGYSRPRASSKEKAHSRSRTPS 624
             R+PS+   RR+SRS    R  S       RSR+P ++     P    + ++  R R+P 
Sbjct: 1992 SRTPSR---RRRSRSVVRRRSFSISPVRLRRSRTPLRRRFSRSPIRRKRSRSSERGRSPK 2048

Query: 625  KEGNHSQSR-----TSSKESDPSQSTVPRSPDWKRSPTRT 659
            +  +  +++      ++  +  +++ VP  P+ K +P  T
Sbjct: 2049 RLTDLDKAQLLEIAKANAAAMCAKAGVPLPPNLKPAPPPT 2088



 Score = 90.5 bits (223), Expect = 5e-18
 Identities = 92/275 (33%), Positives = 134/275 (48%), Gaps = 43/275 (15%)

Query: 413  RSRSRSPYKARDRSRSRSPNKARDCSRSRSPYKARDRSRSRSPN-----KARDHSRSRSP 467
            R+    P  A D  R RS   A     S  P +A + S     +     K +D       
Sbjct: 1749 RAGIEGPLLASDVGRDRS---AASPVVSSMPERASESSSEEKDDYEIFVKVKDTHEKSKK 1805

Query: 468  NKARDRSRSRSPSKERDHS--QLGSPSKERDHRRSRSPSKERQCRQSRSSSKERDHR--- 522
            NK RD+       K+RD S       SK  +H+ SR  + E + R  + SSK + HR   
Sbjct: 1806 NKNRDKGEKE---KKRDSSLRSRSKRSKSSEHK-SRKRTSESRSRARKRSSKSKSHRSQT 1861

Query: 523  RSRSPSKERQRRQSRSPNKERDRSQSRSPSEEREHRQSRSPSKERDRRRWRSPSKERERR 582
            RSRS S+ R+RR SRS +K R R   RS S+E+  R  +  SK R+R+R RS S++  + 
Sbjct: 1862 RSRSRSR-RRRRSSRSRSKSRGR---RSVSKEKRKRSPKHRSKSRERKRKRSSSRDNRKT 1917

Query: 583  QSRSSSEERDHSRSRSPNKQSGYSRPRASSKEKAHS-----RSRTPSKEGNHSQSRTSSK 637
                S      SRS +P+++    R R+  + ++ S     RSRTPS+     +SRT S+
Sbjct: 1918 VRARSRTPSRRSRSHTPSRR---RRSRSVGRRRSFSISPSRRSRTPSR-----RSRTPSR 1969

Query: 638  ES-DPSQSTVPRSPDWK-RSPTRTSSLSQNRTPSK 670
             S  PS+ +  R+P  + R+P+R S     RTPS+
Sbjct: 1970 RSRTPSRRS--RTPSRRSRTPSRRS-----RTPSR 1997



 Score = 84.3 bits (207), Expect = 3e-16
 Identities = 74/240 (30%), Positives = 111/240 (46%), Gaps = 19/240 (7%)

Query: 443  PYKARDRSRSRSPNKARDHSRSRSPNKARDRSRSRSPSKE-----RDHSQLGSPSKERDH 497
            P  A D  R RS   A     S  P +A + S       E     +D  +    +K RD 
Sbjct: 1755 PLLASDVGRDRS---AASPVVSSMPERASESSSEEKDDYEIFVKVKDTHEKSKKNKNRD- 1810

Query: 498  RRSRSPSKERQCRQSRSSSKERDHRRSRSPSKERQRRQSRSPNKERDRSQSRSPSEEREH 557
            +  +   ++   R     SK  +H+  +  S+ R R + RS   +  RSQ+RS S  R  
Sbjct: 1811 KGEKEKKRDSSLRSRSKRSKSSEHKSRKRTSESRSRARKRSSKSKSHRSQTRSRSRSRRR 1870

Query: 558  RQ-SRSPSKERDRRRWRSPSKERERRQSRSSSEERDHSRSRSPNKQSGYSRPRASSKEKA 616
            R+ SRS SK R R   RS SKE+ +R  +  S+ R+  R RS ++ +  +    S     
Sbjct: 1871 RRSSRSRSKSRGR---RSVSKEKRKRSPKHRSKSRERKRKRSSSRDNRKTVRARSRTPSR 1927

Query: 617  HSRSRTPS-KEGNHSQSRTSSKESDPSQSTVPRSPDWK-RSPTRTSSL--SQNRTPSKTS 672
             SRS TPS +  + S  R  S    PS+ +  R+P  + R+P+R S     ++RTPS+ S
Sbjct: 1928 RSRSHTPSRRRRSRSVGRRRSFSISPSRRS--RTPSRRSRTPSRRSRTPSRRSRTPSRRS 1985



 Score = 77.0 bits (188), Expect = 6e-14
 Identities = 71/246 (28%), Positives = 116/246 (47%), Gaps = 16/246 (6%)

Query: 459  RDHSRSRSPNKARDRSRSRSPSKERDHSQLGSPSKERDHRRSRSPSKERQCRQSRSSSKE 518
            RD S +     +     S S S+E+D  ++    K+   +  ++ ++++  ++ +  S  
Sbjct: 1763 RDRSAASPVVSSMPERASESSSEEKDDYEIFVKVKDTHEKSKKNKNRDKGEKEKKRDSSL 1822

Query: 519  RDHRRSRSPSKERQRRQSRSPNKERDRSQSRSPSEEREHRQSRSPSKERDRRRWRSPSKE 578
            R  R  RS S E + R+  S ++ R R +S      R   +SRS S+ R RR  RS SK 
Sbjct: 1823 RS-RSKRSKSSEHKSRKRTSESRSRARKRSSKSKSHRSQTRSRSRSRRR-RRSSRSRSKS 1880

Query: 579  RERRQSRSSSEERDHSRSRSPNKQSGYSRPRASSKEK---AHSRSRTPSKEG-NHSQSRT 634
            R R   RS S+E+     +  +K     R R+SS++      +RSRTPS+   +H+ SR 
Sbjct: 1881 RGR---RSVSKEKRKRSPKHRSKSRERKRKRSSSRDNRKTVRARSRTPSRRSRSHTPSRR 1937

Query: 635  SSKESDPSQSTVPRSPDWK-RSPTRTSSLSQNRTPSKTSSHSPSTFPSGGQTLSQDDSQA 693
                S   + +   SP  + R+P+R S     RTPS+  S +PS         S+  S+ 
Sbjct: 1938 RRSRSVGRRRSFSISPSRRSRTPSRRS-----RTPSR-RSRTPSRRSRTPSRRSRTPSRR 1991

Query: 694  DATTSK 699
              T S+
Sbjct: 1992 SRTPSR 1997



 Score = 67.4 bits (163), Expect = 4e-11
 Identities = 64/216 (29%), Positives = 100/216 (46%), Gaps = 15/216 (6%)

Query: 510  RQSRSSSKERDH-------RRSRSPSKERQRRQSRSPNKERDRS-QSRSP-SEEREHRQS 560
            R S SSS+E+D        + +   SK+ + R      K+RD S +SRS  S+  EH+  
Sbjct: 1778 RASESSSEEKDDYEIFVKVKDTHEKSKKNKNRDKGEKEKKRDSSLRSRSKRSKSSEHKSR 1837

Query: 561  RSPSKERDRRRWRSPSKERERRQSRSSSEERDHSRSRSPNKQSGYSRPRASSKEKAHSRS 620
            +  S+ R R R RS   +  R Q+RS S  R   R RS   +S     R+ SKEK     
Sbjct: 1838 KRTSESRSRARKRSSKSKSHRSQTRSRSRSR--RRRRSSRSRSKSRGRRSVSKEKRKRSP 1895

Query: 621  RTPSKEGNHSQSRTSSKESDPSQSTVPRSPDWKRSPTRTSS---LSQNRTPSKTSSHSPS 677
            +  SK     + R+SS+++  +     R+P  +RS + T S    S++    ++ S SPS
Sbjct: 1896 KHRSKSRERKRKRSSSRDNRKTVRARSRTPS-RRSRSHTPSRRRRSRSVGRRRSFSISPS 1954

Query: 678  TFPSGGQTLSQDDSQADATTSKATLPGERSSSSSSK 713
                     S+  S+   T S+ +    R S + S+
Sbjct: 1955 RRSRTPSRRSRTPSRRSRTPSRRSRTPSRRSRTPSR 1990



 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 80/313 (25%), Positives = 127/313 (40%), Gaps = 47/313 (15%)

Query: 33   KSTKSATPNRSLVPTKPATSRNSVMSPSSSKSTKSTSTKRAPSNRPSSRSRVRSKARTPS 92
            +   +A+P  S +P + + S       S  K       K   ++  S +++ R K     
Sbjct: 1763 RDRSAASPVVSSMPERASESS------SEEKDDYEIFVKVKDTHEKSKKNKNRDKGEKEK 1816

Query: 93   RVSTDTRT-SKASKASDVRCHQRRGTHSRGRTPGRRGSRSSKRSPSRASTPGRIRTHGAR 151
            +  +  R+ SK SK+S+ +  ++R + SR R   R     S RS +R+ +  R R   +R
Sbjct: 1817 KRDSSLRSRSKRSKSSEHKS-RKRTSESRSRARKRSSKSKSHRSQTRSRSRSRRRRRSSR 1875

Query: 152  PGMASRVRTPTSQQKGSRG-KSYGRPRTSNRERSDSQP--------------RNLSKKSY 196
                SR R   S++K  R  K   + R   R+RS S+               R+ S    
Sbjct: 1876 SRSKSRGRRSVSKEKRKRSPKHRSKSRERKRKRSSSRDNRKTVRARSRTPSRRSRSHTPS 1935

Query: 197  RPPGGSGIGRSSELAVTPSTAKCQTPTGIPSKEKSDNPSPSSSRKVKSYGQMIIPSREKS 256
            R      +GR    +++PS  + +TP+      +S  PS  S            PSR +S
Sbjct: 1936 RRRRSRSVGRRRSFSISPS-RRSRTPS-----RRSRTPSRRSR----------TPSR-RS 1978

Query: 257  YSPTEMSSRVKSYNQASTRSR-PQSHSQSRSPRRSRSGSQKRTHSRVRSHSWKRNHSRAR 315
             +P+  S         S RSR P    +SRS  R RS S      R      +R  SR+ 
Sbjct: 1979 RTPSRRS------RTPSRRSRTPSRRRRSRSVVRRRSFSISPVRLRRSRTPLRRRFSRSP 2032

Query: 316  SRTRKGILSQMGR 328
             R ++   S+ GR
Sbjct: 2033 IRRKRSRSSERGR 2045



 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 75/274 (27%), Positives = 114/274 (41%), Gaps = 48/274 (17%)

Query: 25   DPKPPASLKSTKS---ATPNRSLVPTKPATSRNSVMSPSSSKSTKSTSTKRAPSNRPSSR 81
            + K  +SL+S      ++ ++S   T  + SR    S S SKS +S +  R+ S R    
Sbjct: 1815 EKKRDSSLRSRSKRSKSSEHKSRKRTSESRSRARKRS-SKSKSHRSQTRSRSRSRRRRRS 1873

Query: 82   SRVRSKARTPSRVSTDTRTSKASKASDVRCHQRRGTHSRGRTPGRRGSRSSKRSPSRAS- 140
            SR RSK+R    VS + R       S  R  +R+ + SR     R+  R+  R+PSR S 
Sbjct: 1874 SRSRSKSRGRRSVSKEKRKRSPKHRSKSRERKRKRSSSRDN---RKTVRARSRTPSRRSR 1930

Query: 141  --TPGRIRTHGARPGMASRVRTPTSQQKGSRGKSYGRPRTSNRERSDSQPRNLSKKSYRP 198
              TP R R                      R +S GR R+ +   S  + R  S++S  P
Sbjct: 1931 SHTPSRRR----------------------RSRSVGRRRSFSISPS-RRSRTPSRRSRTP 1967

Query: 199  PGGSGIGRSSELAVTPSTAKCQTPTGIPSKEKSDNPSPSSSRKVKSYGQMIIPSREKSYS 258
                     S  + TPS  + +TP+         + +PS  R+ +S    ++  R  S S
Sbjct: 1968 ---------SRRSRTPS-RRSRTPSRRSRTPSRRSRTPSRRRRSRS----VVRRRSFSIS 2013

Query: 259  PTEMSSRVKSYNQASTRSRPQSHSQSRSPRRSRS 292
            P  +        +  +RS P    +SRS  R RS
Sbjct: 2014 PVRLRRSRTPLRRRFSRS-PIRRKRSRSSERGRS 2046



 Score = 31.2 bits (69), Expect = 3.5
 Identities = 24/94 (25%), Positives = 42/94 (44%), Gaps = 4/94 (4%)

Query: 7    SSKPSMSLAPSGSSMPTADPKPPASLKST--KSAT--PNRSLVPTKPATSRNSVMSPSSS 62
            +S PS+ ++ +  ++P   P+P +S+  T  +SA       +VP +P T   S     S+
Sbjct: 1234 ASDPSVLVSEAAVTVPEPPPEPESSITLTPVESAVVAEEHEVVPERPVTCMVSETPAMSA 1293

Query: 63   KSTKSTSTKRAPSNRPSSRSRVRSKARTPSRVST 96
            + T   S     S    +   +R+     S VST
Sbjct: 1294 EPTVLASEPPVMSETAETFDSMRASGHVASEVST 1327


>gi|21040314 SON DNA-binding protein isoform B [Homo sapiens]
          Length = 2303

 Score =  108 bits (270), Expect = 2e-23
 Identities = 123/460 (26%), Positives = 199/460 (43%), Gaps = 71/460 (15%)

Query: 221  TPTGIPSKEKSDNPSPSSSRKVKSYGQMIIPSREKSYSPTE-MSSRVKSYNQASTRSRPQ 279
            T   +P KE     +   S K  S G+  +P   K   P    S+ ++  N+A    RP 
Sbjct: 1679 TEEPLPVKESDQTLAALLSPKESSGGEKEVPPPPKETLPDSGFSANIEDINEADL-VRPL 1737

Query: 280  SHSQSRSPRRSRSGSQKRTHSRVRSHSWKRNHSRARSRTRKGILSQMGRHSQSRSHSKGK 339
                       R+G        +       +  R RS     + S   R S+S S  K  
Sbjct: 1738 LPKDMERLTSLRAG--------IEGPLLASDVGRDRSAASPVVSSMPERASESSSEEKDD 1789

Query: 340  SQNQSRTPRRGRSHNWSRNPSKERSHSHSRSSSKERDHRGSSSPRKESGRSQSGSPNKQR 399
             +   +              + E+S  +      E++ +  SS R  S RS+S     ++
Sbjct: 1790 YEIFVKV-----------KDTHEKSKKNKNRDKGEKEKKRDSSLRSRSKRSKSSEHKSRK 1838

Query: 400  DHSRSRSPNKARDRSRSRSPYKARDRSRSRSPNKARDCSRSRSPYKARDRSRSRSPNKAR 459
              S SRS  +AR RS     ++++ RSRSRS  + R          +R RS+SR      
Sbjct: 1839 RTSESRS--RARKRSSKSKSHRSQTRSRSRSRRRRRS---------SRSRSKSRGRRSVS 1887

Query: 460  DHSRSRSP-NKARDRSRSRSPSKERDHSQLGSPSKERDHRRSRSPSKERQCRQSRSSSKE 518
               R RSP ++++ R R R  S  RD+ +          RRSRS +  R+ R+SRS  + 
Sbjct: 1888 KEKRKRSPKHRSKSRERKRKRSSSRDNRKTVRARSRTPSRRSRSHTPSRR-RRSRSVGRR 1946

Query: 519  RDH-----RRSRSPSKERQ--RRQSRSPNKERDRSQSRSPSEEREHRQSRSPSKERDRRR 571
            R       RRSR+PS+  +   R+SR+P++     +SR+PS     R+SR+PS     RR
Sbjct: 1947 RSFSISPSRRSRTPSRRSRTPSRRSRTPSR-----RSRTPS-----RRSRTPS-----RR 1991

Query: 572  WRSPSKERERRQSRSSSEERDHS-------RSRSPNKQSGYSRPRASSKEKAHSRSRTPS 624
             R+PS+   RR+SRS    R  S       RSR+P ++     P    + ++  R R+P 
Sbjct: 1992 SRTPSR---RRRSRSVVRRRSFSISPVRLRRSRTPLRRRFSRSPIRRKRSRSSERGRSPK 2048

Query: 625  KEGNHSQSR-----TSSKESDPSQSTVPRSPDWKRSPTRT 659
            +  +  +++      ++  +  +++ VP  P+ K +P  T
Sbjct: 2049 RLTDLDKAQLLEIAKANAAAMCAKAGVPLPPNLKPAPPPT 2088



 Score = 90.5 bits (223), Expect = 5e-18
 Identities = 92/275 (33%), Positives = 134/275 (48%), Gaps = 43/275 (15%)

Query: 413  RSRSRSPYKARDRSRSRSPNKARDCSRSRSPYKARDRSRSRSPN-----KARDHSRSRSP 467
            R+    P  A D  R RS   A     S  P +A + S     +     K +D       
Sbjct: 1749 RAGIEGPLLASDVGRDRS---AASPVVSSMPERASESSSEEKDDYEIFVKVKDTHEKSKK 1805

Query: 468  NKARDRSRSRSPSKERDHS--QLGSPSKERDHRRSRSPSKERQCRQSRSSSKERDHR--- 522
            NK RD+       K+RD S       SK  +H+ SR  + E + R  + SSK + HR   
Sbjct: 1806 NKNRDKGEKE---KKRDSSLRSRSKRSKSSEHK-SRKRTSESRSRARKRSSKSKSHRSQT 1861

Query: 523  RSRSPSKERQRRQSRSPNKERDRSQSRSPSEEREHRQSRSPSKERDRRRWRSPSKERERR 582
            RSRS S+ R+RR SRS +K R R   RS S+E+  R  +  SK R+R+R RS S++  + 
Sbjct: 1862 RSRSRSR-RRRRSSRSRSKSRGR---RSVSKEKRKRSPKHRSKSRERKRKRSSSRDNRKT 1917

Query: 583  QSRSSSEERDHSRSRSPNKQSGYSRPRASSKEKAHS-----RSRTPSKEGNHSQSRTSSK 637
                S      SRS +P+++    R R+  + ++ S     RSRTPS+     +SRT S+
Sbjct: 1918 VRARSRTPSRRSRSHTPSRR---RRSRSVGRRRSFSISPSRRSRTPSR-----RSRTPSR 1969

Query: 638  ES-DPSQSTVPRSPDWK-RSPTRTSSLSQNRTPSK 670
             S  PS+ +  R+P  + R+P+R S     RTPS+
Sbjct: 1970 RSRTPSRRS--RTPSRRSRTPSRRS-----RTPSR 1997



 Score = 84.3 bits (207), Expect = 3e-16
 Identities = 74/240 (30%), Positives = 111/240 (46%), Gaps = 19/240 (7%)

Query: 443  PYKARDRSRSRSPNKARDHSRSRSPNKARDRSRSRSPSKE-----RDHSQLGSPSKERDH 497
            P  A D  R RS   A     S  P +A + S       E     +D  +    +K RD 
Sbjct: 1755 PLLASDVGRDRS---AASPVVSSMPERASESSSEEKDDYEIFVKVKDTHEKSKKNKNRD- 1810

Query: 498  RRSRSPSKERQCRQSRSSSKERDHRRSRSPSKERQRRQSRSPNKERDRSQSRSPSEEREH 557
            +  +   ++   R     SK  +H+  +  S+ R R + RS   +  RSQ+RS S  R  
Sbjct: 1811 KGEKEKKRDSSLRSRSKRSKSSEHKSRKRTSESRSRARKRSSKSKSHRSQTRSRSRSRRR 1870

Query: 558  RQ-SRSPSKERDRRRWRSPSKERERRQSRSSSEERDHSRSRSPNKQSGYSRPRASSKEKA 616
            R+ SRS SK R R   RS SKE+ +R  +  S+ R+  R RS ++ +  +    S     
Sbjct: 1871 RRSSRSRSKSRGR---RSVSKEKRKRSPKHRSKSRERKRKRSSSRDNRKTVRARSRTPSR 1927

Query: 617  HSRSRTPS-KEGNHSQSRTSSKESDPSQSTVPRSPDWK-RSPTRTSSL--SQNRTPSKTS 672
             SRS TPS +  + S  R  S    PS+ +  R+P  + R+P+R S     ++RTPS+ S
Sbjct: 1928 RSRSHTPSRRRRSRSVGRRRSFSISPSRRS--RTPSRRSRTPSRRSRTPSRRSRTPSRRS 1985



 Score = 77.0 bits (188), Expect = 6e-14
 Identities = 71/246 (28%), Positives = 116/246 (47%), Gaps = 16/246 (6%)

Query: 459  RDHSRSRSPNKARDRSRSRSPSKERDHSQLGSPSKERDHRRSRSPSKERQCRQSRSSSKE 518
            RD S +     +     S S S+E+D  ++    K+   +  ++ ++++  ++ +  S  
Sbjct: 1763 RDRSAASPVVSSMPERASESSSEEKDDYEIFVKVKDTHEKSKKNKNRDKGEKEKKRDSSL 1822

Query: 519  RDHRRSRSPSKERQRRQSRSPNKERDRSQSRSPSEEREHRQSRSPSKERDRRRWRSPSKE 578
            R  R  RS S E + R+  S ++ R R +S      R   +SRS S+ R RR  RS SK 
Sbjct: 1823 RS-RSKRSKSSEHKSRKRTSESRSRARKRSSKSKSHRSQTRSRSRSRRR-RRSSRSRSKS 1880

Query: 579  RERRQSRSSSEERDHSRSRSPNKQSGYSRPRASSKEK---AHSRSRTPSKEG-NHSQSRT 634
            R R   RS S+E+     +  +K     R R+SS++      +RSRTPS+   +H+ SR 
Sbjct: 1881 RGR---RSVSKEKRKRSPKHRSKSRERKRKRSSSRDNRKTVRARSRTPSRRSRSHTPSRR 1937

Query: 635  SSKESDPSQSTVPRSPDWK-RSPTRTSSLSQNRTPSKTSSHSPSTFPSGGQTLSQDDSQA 693
                S   + +   SP  + R+P+R S     RTPS+  S +PS         S+  S+ 
Sbjct: 1938 RRSRSVGRRRSFSISPSRRSRTPSRRS-----RTPSR-RSRTPSRRSRTPSRRSRTPSRR 1991

Query: 694  DATTSK 699
              T S+
Sbjct: 1992 SRTPSR 1997



 Score = 67.4 bits (163), Expect = 4e-11
 Identities = 64/216 (29%), Positives = 100/216 (46%), Gaps = 15/216 (6%)

Query: 510  RQSRSSSKERDH-------RRSRSPSKERQRRQSRSPNKERDRS-QSRSP-SEEREHRQS 560
            R S SSS+E+D        + +   SK+ + R      K+RD S +SRS  S+  EH+  
Sbjct: 1778 RASESSSEEKDDYEIFVKVKDTHEKSKKNKNRDKGEKEKKRDSSLRSRSKRSKSSEHKSR 1837

Query: 561  RSPSKERDRRRWRSPSKERERRQSRSSSEERDHSRSRSPNKQSGYSRPRASSKEKAHSRS 620
            +  S+ R R R RS   +  R Q+RS S  R   R RS   +S     R+ SKEK     
Sbjct: 1838 KRTSESRSRARKRSSKSKSHRSQTRSRSRSR--RRRRSSRSRSKSRGRRSVSKEKRKRSP 1895

Query: 621  RTPSKEGNHSQSRTSSKESDPSQSTVPRSPDWKRSPTRTSS---LSQNRTPSKTSSHSPS 677
            +  SK     + R+SS+++  +     R+P  +RS + T S    S++    ++ S SPS
Sbjct: 1896 KHRSKSRERKRKRSSSRDNRKTVRARSRTPS-RRSRSHTPSRRRRSRSVGRRRSFSISPS 1954

Query: 678  TFPSGGQTLSQDDSQADATTSKATLPGERSSSSSSK 713
                     S+  S+   T S+ +    R S + S+
Sbjct: 1955 RRSRTPSRRSRTPSRRSRTPSRRSRTPSRRSRTPSR 1990



 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 80/313 (25%), Positives = 127/313 (40%), Gaps = 47/313 (15%)

Query: 33   KSTKSATPNRSLVPTKPATSRNSVMSPSSSKSTKSTSTKRAPSNRPSSRSRVRSKARTPS 92
            +   +A+P  S +P + + S       S  K       K   ++  S +++ R K     
Sbjct: 1763 RDRSAASPVVSSMPERASESS------SEEKDDYEIFVKVKDTHEKSKKNKNRDKGEKEK 1816

Query: 93   RVSTDTRT-SKASKASDVRCHQRRGTHSRGRTPGRRGSRSSKRSPSRASTPGRIRTHGAR 151
            +  +  R+ SK SK+S+ +  ++R + SR R   R     S RS +R+ +  R R   +R
Sbjct: 1817 KRDSSLRSRSKRSKSSEHKS-RKRTSESRSRARKRSSKSKSHRSQTRSRSRSRRRRRSSR 1875

Query: 152  PGMASRVRTPTSQQKGSRG-KSYGRPRTSNRERSDSQP--------------RNLSKKSY 196
                SR R   S++K  R  K   + R   R+RS S+               R+ S    
Sbjct: 1876 SRSKSRGRRSVSKEKRKRSPKHRSKSRERKRKRSSSRDNRKTVRARSRTPSRRSRSHTPS 1935

Query: 197  RPPGGSGIGRSSELAVTPSTAKCQTPTGIPSKEKSDNPSPSSSRKVKSYGQMIIPSREKS 256
            R      +GR    +++PS  + +TP+      +S  PS  S            PSR +S
Sbjct: 1936 RRRRSRSVGRRRSFSISPS-RRSRTPS-----RRSRTPSRRSR----------TPSR-RS 1978

Query: 257  YSPTEMSSRVKSYNQASTRSR-PQSHSQSRSPRRSRSGSQKRTHSRVRSHSWKRNHSRAR 315
             +P+  S         S RSR P    +SRS  R RS S      R      +R  SR+ 
Sbjct: 1979 RTPSRRS------RTPSRRSRTPSRRRRSRSVVRRRSFSISPVRLRRSRTPLRRRFSRSP 2032

Query: 316  SRTRKGILSQMGR 328
             R ++   S+ GR
Sbjct: 2033 IRRKRSRSSERGR 2045



 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 75/274 (27%), Positives = 114/274 (41%), Gaps = 48/274 (17%)

Query: 25   DPKPPASLKSTKS---ATPNRSLVPTKPATSRNSVMSPSSSKSTKSTSTKRAPSNRPSSR 81
            + K  +SL+S      ++ ++S   T  + SR    S S SKS +S +  R+ S R    
Sbjct: 1815 EKKRDSSLRSRSKRSKSSEHKSRKRTSESRSRARKRS-SKSKSHRSQTRSRSRSRRRRRS 1873

Query: 82   SRVRSKARTPSRVSTDTRTSKASKASDVRCHQRRGTHSRGRTPGRRGSRSSKRSPSRAS- 140
            SR RSK+R    VS + R       S  R  +R+ + SR     R+  R+  R+PSR S 
Sbjct: 1874 SRSRSKSRGRRSVSKEKRKRSPKHRSKSRERKRKRSSSRDN---RKTVRARSRTPSRRSR 1930

Query: 141  --TPGRIRTHGARPGMASRVRTPTSQQKGSRGKSYGRPRTSNRERSDSQPRNLSKKSYRP 198
              TP R R                      R +S GR R+ +   S  + R  S++S  P
Sbjct: 1931 SHTPSRRR----------------------RSRSVGRRRSFSISPS-RRSRTPSRRSRTP 1967

Query: 199  PGGSGIGRSSELAVTPSTAKCQTPTGIPSKEKSDNPSPSSSRKVKSYGQMIIPSREKSYS 258
                     S  + TPS  + +TP+         + +PS  R+ +S    ++  R  S S
Sbjct: 1968 ---------SRRSRTPS-RRSRTPSRRSRTPSRRSRTPSRRRRSRS----VVRRRSFSIS 2013

Query: 259  PTEMSSRVKSYNQASTRSRPQSHSQSRSPRRSRS 292
            P  +        +  +RS P    +SRS  R RS
Sbjct: 2014 PVRLRRSRTPLRRRFSRS-PIRRKRSRSSERGRS 2046



 Score = 31.2 bits (69), Expect = 3.5
 Identities = 24/94 (25%), Positives = 42/94 (44%), Gaps = 4/94 (4%)

Query: 7    SSKPSMSLAPSGSSMPTADPKPPASLKST--KSAT--PNRSLVPTKPATSRNSVMSPSSS 62
            +S PS+ ++ +  ++P   P+P +S+  T  +SA       +VP +P T   S     S+
Sbjct: 1234 ASDPSVLVSEAAVTVPEPPPEPESSITLTPVESAVVAEEHEVVPERPVTCMVSETPAMSA 1293

Query: 63   KSTKSTSTKRAPSNRPSSRSRVRSKARTPSRVST 96
            + T   S     S    +   +R+     S VST
Sbjct: 1294 EPTVLASEPPVMSETAETFDSMRASGHVASEVST 1327


>gi|4759100 splicing factor, arginine/serine-rich 11 [Homo sapiens]
          Length = 484

 Score =  108 bits (269), Expect = 2e-23
 Identities = 93/288 (32%), Positives = 138/288 (47%), Gaps = 30/288 (10%)

Query: 368 SRSSSKERDHRGSSSPRKESGRSQSGSPNKQ---RDHSRSRSPNKARDRSRSRSPYKARD 424
           S +SSKE +         +S  S +  P+K+   R HSRSRS ++ R    S    ++R 
Sbjct: 212 SDTSSKEIEEAMKRVREAQSLISAAIEPDKKEEKRRHSRSRSRSRRRRTPSSSRHRRSRS 271

Query: 425 RSRSRSPNKARDCSRSRSPYKARDRSRSRSPNKARDHSRSRSPNKARDRSRSRSPSKERD 484
           RSR RS +K+R   RS+SP + R  SR R         RSRS +K RD+ +     KE+ 
Sbjct: 272 RSRRRSHSKSRSRRRSKSPRRRRSHSRERG-------RRSRSTSKTRDKKKE---DKEKK 321

Query: 485 HSQLGSPSKERDHRRSRSPSKERQCRQSRSSS----KERDHRR--SRSPSKERQRRQSRS 538
            S+   P      RRSRS S+ER+ R+SRS +    K R  +R  SRSPS  R +++ + 
Sbjct: 322 RSKT-PPKSYSTARRSRSASRERRRRRSRSGTRSPKKPRSPKRKLSRSPSPRRHKKEKK- 379

Query: 539 PNKERDRSQSRSPSEEREHRQSRSPSKERDRRRWRSPSKERERRQSRSSSEERDHSRSRS 598
             K++D+ +SR   E    ++ +S  KE+DR R +S S +  ++ +R   EE     S  
Sbjct: 380 --KDKDKERSRDERERSTSKKKKSKDKEKDRER-KSESDKDVKQVTRDYDEEEQGYDSEK 436

Query: 599 PNK------QSGYSRPRASSKEKAHSRSRTPSKEGNHSQSRTSSKESD 640
             K      ++G  + +  S EK    S   SK             SD
Sbjct: 437 EKKEEKKPIETGSPKTKECSVEKGTGDSLRESKVNGDDHHEEDMDMSD 484



 Score = 97.8 bits (242), Expect = 3e-20
 Identities = 78/269 (28%), Positives = 123/269 (45%), Gaps = 32/269 (11%)

Query: 328 RHSQSRSHSKGKSQNQSRTPRRGRSHNWSRNPSKERSHSHSRSSSKERDHRGSSSPRKES 387
           RHS+SRS S+ +     RTP   R H  SR+ S+ RSHS SRS  + +  R   S  +E 
Sbjct: 247 RHSRSRSRSRRR-----RTPSSSR-HRRSRSRSRRRSHSKSRSRRRSKSPRRRRSHSRER 300

Query: 388 GRSQSGSPNKQRDHSRSRSPNKARDRSRSRSPYKARDRSRSRSPNKARDCSRSRSPYKAR 447
           GR             RSRS +K RD+ +     + +++ RS++P K+   +R RS   +R
Sbjct: 301 GR-------------RSRSTSKTRDKKK-----EDKEKKRSKTPPKSYSTAR-RSRSASR 341

Query: 448 DRSRSRSPNKARDHSRSRSPNKARDRSRSRSPSKERDHSQLGSPSKERDHRRSRSPSKER 507
           +R R RS +  R   + RSP     R  SRSPS  R   +     K++D  RSR   +  
Sbjct: 342 ERRRRRSRSGTRSPKKPRSPK----RKLSRSPSPRRHKKE---KKKDKDKERSRDERERS 394

Query: 508 QCRQSRSSSKERDHRRSRSPSKERQRRQSRSPNKERDRSQSRSPSEEREHRQSRSPSKER 567
             ++ +S  KE+D  R     K+ ++       +E+     +   EE++  ++ SP  + 
Sbjct: 395 TSKKKKSKDKEKDRERKSESDKDVKQVTRDYDEEEQGYDSEKEKKEEKKPIETGSPKTKE 454

Query: 568 DRRRWRSPSKERERRQSRSSSEERDHSRS 596
                 +    RE + +     E D   S
Sbjct: 455 CSVEKGTGDSLRESKVNGDDHHEEDMDMS 483



 Score = 97.1 bits (240), Expect = 5e-20
 Identities = 81/307 (26%), Positives = 130/307 (42%), Gaps = 34/307 (11%)

Query: 248 MIIPSREKSYSPTEMSSRVKSYNQA----STRSRPQSHSQSRSPRRSRSGSQKRTHSRVR 303
           ++ PS +   S  E+   +K   +A    S    P    + R   RSRS S++R      
Sbjct: 205 LVSPSLKSDTSSKEIEEAMKRVREAQSLISAAIEPDKKEEKRRHSRSRSRSRRRRTPSSS 264

Query: 304 SHSWKRNHSRARSRTRKGILSQMGRHSQSRSHSKGKSQNQSRTPRRGRSHNWSRNPSKER 363
            H  +R+ SR+R                 RSHSK +S+ +S++PRR RSH      S+ER
Sbjct: 265 RH--RRSRSRSR----------------RRSHSKSRSRRRSKSPRRRRSH------SRER 300

Query: 364 SHSHSRSSSKERDHRGSSSPRKESGRSQSGSPNKQRDHSRSRSPNKARDRSRSRSPYKAR 423
               SRS+SK RD +     +K S          +R  S SR   + R RS +RSP K R
Sbjct: 301 GR-RSRSTSKTRDKKKEDKEKKRSKTPPKSYSTARRSRSASRERRRRRSRSGTRSPKKPR 359

Query: 424 D--RSRSRSPNKARDCSRSRSPYKARDRSRSRSPNKARDHSRSRSPNKARDRSRSRSPSK 481
              R  SRSP+  R     +   K +D+ RSR   +     + +S +K +DR R     K
Sbjct: 360 SPKRKLSRSPSPRR---HKKEKKKDKDKERSRDERERSTSKKKKSKDKEKDRERKSESDK 416

Query: 482 ERDHSQLGSPSKERDHRRSRSPSKERQCRQSRSSSKERDHRRSRSPSKERQRRQSRSPNK 541
           +          +E+ +   +   +E++  ++ S   +       +    R+ + +   + 
Sbjct: 417 DVKQVTRDYDEEEQGYDSEKEKKEEKKPIETGSPKTKECSVEKGTGDSLRESKVNGDDHH 476

Query: 542 ERDRSQS 548
           E D   S
Sbjct: 477 EEDMDMS 483



 Score = 91.7 bits (226), Expect = 2e-18
 Identities = 72/241 (29%), Positives = 115/241 (47%), Gaps = 32/241 (13%)

Query: 445 KARDRSRSRSPNKARDHSRSRSPNKARDRSRSRSPSKERDHSQLGSPSKERDHRRSRSPS 504
           K   R  SRS +++R   R R+P+ +R R RSRS S+ R HS      K R  RRS+SP 
Sbjct: 242 KEEKRRHSRSRSRSR---RRRTPSSSRHR-RSRSRSRRRSHS------KSRSRRRSKSPR 291

Query: 505 KER-----QCRQSRSSSKERD-------HRRSRSPSK-----ERQRRQSRSPNKERDRSQ 547
           + R     + R+SRS+SK RD        +RS++P K      R R  SR   + R RS 
Sbjct: 292 RRRSHSRERGRRSRSTSKTRDKKKEDKEKKRSKTPPKSYSTARRSRSASRERRRRRSRSG 351

Query: 548 SRSPSEER--EHRQSRSPSKERDRRRWRSPSKERERRQSRSSSEERDHSRSRSPNKQSGY 605
           +RSP + R  + + SRSPS    RR  +   K++++ +SR   E     + +S +K+   
Sbjct: 352 TRSPKKPRSPKRKLSRSPS---PRRHKKEKKKDKDKERSRDERERSTSKKKKSKDKEKDR 408

Query: 606 SRPRASSKEKAHSRSRTPSKEGNHSQSRTSSKESDPSQSTVPRSPDWKRSPTRTSSLSQN 665
            R   S K+          +E  +   +   +E  P ++  P++ +         SL ++
Sbjct: 409 ERKSESDKDVKQVTRDYDEEEQGYDSEKEKKEEKKPIETGSPKTKECSVEKGTGDSLRES 468

Query: 666 R 666
           +
Sbjct: 469 K 469



 Score = 74.7 bits (182), Expect = 3e-13
 Identities = 71/231 (30%), Positives = 108/231 (46%), Gaps = 27/231 (11%)

Query: 488 LGSPSKERDHRRSRSPSKERQCRQSRS---SSKERDHRRSRSPSKERQRRQSRSPNKERD 544
           L SPS + D          ++ R+++S   ++ E D        KE +RR SRS ++ R 
Sbjct: 205 LVSPSLKSDTSSKEIEEAMKRVREAQSLISAAIEPD-------KKEEKRRHSRSRSRSRR 257

Query: 545 RSQSRSPSEEREHRQSRSPSKERDRRRWRSPSKERERRQSRSSSEERDHSRSRSPNKQSG 604
           R   R+PS  R HR+SRS      R R RS SK R RR+S+S    R HSR R    +S 
Sbjct: 258 R---RTPSSSR-HRRSRS------RSRRRSHSKSRSRRRSKSPRRRRSHSRERGRRSRST 307

Query: 605 YSRPRASSKEKAHSRSRTPSKE-GNHSQSRTSSKESDPSQS-TVPRSPDWKRSPTRTSSL 662
                   ++K   RS+TP K      +SR++S+E    +S +  RSP   RSP R   L
Sbjct: 308 SKTRDKKKEDKEKKRSKTPPKSYSTARRSRSASRERRRRRSRSGTRSPKKPRSPKR--KL 365

Query: 663 SQNRTPSKTSSHSPSTFPSGGQTLSQDDSQADATTSKATLPGERSSSSSSK 713
           S++ +P +   H         +  S+D+ +   +  K +   E+     S+
Sbjct: 366 SRSPSPRR---HKKEKKKDKDKERSRDERERSTSKKKKSKDKEKDRERKSE 413



 Score = 72.8 bits (177), Expect = 1e-12
 Identities = 73/284 (25%), Positives = 115/284 (40%), Gaps = 34/284 (11%)

Query: 240 RKVKSYGQMIIPSREKSYSPTEMSSRVKSYNQASTRSRPQSHSQSRSPRRSRSGSQKRTH 299
           R+ +S     I   +K        SR +S  + +  S     S+SRS RRS S S+ R  
Sbjct: 227 REAQSLISAAIEPDKKEEKRRHSRSRSRSRRRRTPSSSRHRRSRSRSRRRSHSKSRSRRR 286

Query: 300 SRVRSHSWKRNHSRARSRTRKGILSQMGRHSQSRSHSKGKSQNQSRTPRRGRSHNWSRNP 359
           S  +S   +R+HSR R           GR S+S S ++ K +      R       S+ P
Sbjct: 287 S--KSPRRRRSHSRER-----------GRRSRSTSKTRDKKKEDKEKKR-------SKTP 326

Query: 360 SKERSHS-HSRSSSKERDHRGSSSPRKESGRSQSGSPNKQRDHSR--SRSPNKARDRSRS 416
            K  S +  SRS+S+ER        R+   RS + SP K R   R  SRSP+  R +   
Sbjct: 327 PKSYSTARRSRSASRER--------RRRRSRSGTRSPKKPRSPKRKLSRSPSPRRHKKEK 378

Query: 417 RSPYKARDRSRSRSPNKARDCSRSRSPYKARDRSRSRSPNKARDHSRSRSPNKARDRSRS 476
           +   K +D+ RSR   +     + +S  K +DR R    +K           + +     
Sbjct: 379 K---KDKDKERSRDERERSTSKKKKSKDKEKDRERKSESDKDVKQVTRDYDEEEQGYDSE 435

Query: 477 RSPSKERDHSQLGSPSKERDHRRSRSPSKERQCRQSRSSSKERD 520
           +   +E+   + GSP  +       +    R+ + +     E D
Sbjct: 436 KEKKEEKKPIETGSPKTKECSVEKGTGDSLRESKVNGDDHHEED 479



 Score = 58.2 bits (139), Expect = 3e-08
 Identities = 65/279 (23%), Positives = 104/279 (37%), Gaps = 30/279 (10%)

Query: 22  PTADPK------PPASLKSTKSATPN----RSLVPTKPATSRNSVMSPSSSKSTKSTSTK 71
           PT DP       P A+L S   A        S V  K       ++SPS    T S   +
Sbjct: 161 PTLDPALAALGLPGANLNSQSLAADQLLKLMSTVDPKLNHVAAGLVSPSLKSDTSSKEIE 220

Query: 72  RAPSNRPSSRSRVRSKARTPSRVSTDTRTSKASKASDVRCHQRRGTHSRGRTPGRRGSRS 131
            A      ++S + S A  P +     R S++   S  R       H R R+  RR S S
Sbjct: 221 EAMKRVREAQSLI-SAAIEPDKKEEKRRHSRSRSRSRRRRTPSSSRHRRSRSRSRRRSHS 279

Query: 132 SKRSPSRASTPGRIRTHGARPGMASRVRTPTSQQKGSRGKSYGRPRTSNRERSDSQPRNL 191
             RS  R+ +P R R+H              S+++G R +S  + R   +E  + +    
Sbjct: 280 KSRSRRRSKSPRRRRSH--------------SRERGRRSRSTSKTRDKKKEDKEKKRSKT 325

Query: 192 SKKSYRPPGGS-GIGRSSELAVTPSTAKCQTPTGIPSKEKSDNPSPSSSRKVKSYGQMII 250
             KSY     S    R      + S  +       P ++ S +PSP   +K K   +   
Sbjct: 326 PPKSYSTARRSRSASRERRRRRSRSGTRSPKKPRSPKRKLSRSPSPRRHKKEKKKDK--- 382

Query: 251 PSREKSYSPTEMSSRVKSYNQASTRSRPQSHSQSRSPRR 289
             +E+S    E S+  K  ++   + R +     +  ++
Sbjct: 383 -DKERSRDERERSTSKKKKSKDKEKDRERKSESDKDVKQ 420



 Score = 47.8 bits (112), Expect = 4e-05
 Identities = 94/397 (23%), Positives = 140/397 (35%), Gaps = 95/397 (23%)

Query: 14  LAPSGSSMPTADPKPPAS---LKSTKSATPNRSLVPTK-PATSRNSVMSPSSSKSTKSTS 69
           L P G  +PT +P        L +  + T + +L     P  + NS  S ++ +  K  S
Sbjct: 134 LLPGGGLLPTPNPLTQIGAVPLAALGAPTLDPALAALGLPGANLNS-QSLAADQLLKLMS 192

Query: 70  TKRAPSNR-------PSSRSRVRSKA--RTPSRVSTDTRTSKASKASDVRCHQRRGTHSR 120
           T     N        PS +S   SK       RV        A+   D +  +RR + SR
Sbjct: 193 TVDPKLNHVAAGLVSPSLKSDTSSKEIEEAMKRVREAQSLISAAIEPDKKEEKRRHSRSR 252

Query: 121 GRTPGRRGSRSSKRSPSRASTPGRIRTHGARPGMASRVRTPTSQQKGSRGKSYGRPRTSN 180
            R+  RR   SS+   SR+ +  R R+H                   S+ +S  R ++  
Sbjct: 253 SRSRRRRTPSSSRHRRSRSRS--RRRSH-------------------SKSRSRRRSKSPR 291

Query: 181 RERSDSQPRNLSKKSYRPPGGSGIGRSSELAVTPSTAKCQTPTGIPSKEKSDNPSPSSSR 240
           R RS S+ R               GR S      ST+K +       K+K D     S  
Sbjct: 292 RRRSHSRER---------------GRRSR-----STSKTR------DKKKEDKEKKRSKT 325

Query: 241 KVKSYGQMIIPSREKSYSPTEMSSRVKSYNQASTRSRPQSHSQSRSPRRSRSG--SQKRT 298
             KSY                           ST  R +S S+ R  RRSRSG  S K+ 
Sbjct: 326 PPKSY---------------------------STARRSRSASRERRRRRSRSGTRSPKKP 358

Query: 299 HSRVRSHSWKRNHSRARSRTRKGILSQMGRHSQSRSHSKGKSQNQSRTPRRGRSHNWSRN 358
            S  R  S   +  R +   +K    +  R  + RS SK K        R  +S +    
Sbjct: 359 RSPKRKLSRSPSPRRHKKEKKKDKDKERSRDERERSTSKKKKSKDKEKDRERKSES---- 414

Query: 359 PSKERSHSHSRSSSKERDHRGSSSPRKESGRSQSGSP 395
             K+          +E+ +      ++E    ++GSP
Sbjct: 415 -DKDVKQVTRDYDEEEQGYDSEKEKKEEKKPIETGSP 450



 Score = 33.9 bits (76), Expect = 0.54
 Identities = 30/127 (23%), Positives = 47/127 (37%), Gaps = 11/127 (8%)

Query: 3   SPKRSSKPSMSLAPSGSSMPTADPKPPASLKSTKSATPNRSLVPTKPA----------TS 52
           SP+R    S        S      K     +  +S TP +S    + +           S
Sbjct: 289 SPRRRRSHSRERGRRSRSTSKTRDKKKEDKEKKRSKTPPKSYSTARRSRSASRERRRRRS 348

Query: 53  RNSVMSPSSSKSTKSTSTKRAPSNRPSSRSRVRSKARTPSRVSTDTRTSKASKASDVRCH 112
           R+   SP   +S K     R+PS R   + + + K +  SR   +  TSK  K+ D    
Sbjct: 349 RSGTRSPKKPRSPK-RKLSRSPSPRRHKKEKKKDKDKERSRDERERSTSKKKKSKDKEKD 407

Query: 113 QRRGTHS 119
           + R + S
Sbjct: 408 RERKSES 414


>gi|89276756 serine/threonine-protein kinase PRP4K [Homo sapiens]
          Length = 1007

 Score =  105 bits (262), Expect = 1e-22
 Identities = 112/380 (29%), Positives = 168/380 (44%), Gaps = 53/380 (13%)

Query: 292 SGSQKRTHSRVRSHSWKRNHSRARSRTRKGILSQMGRHSQSRSHSKGKSQNQSRTPRRGR 351
           SGS++     +   +   N S  RS + KG L  +     ++  SK +S+ ++R     +
Sbjct: 142 SGSEEE--GEIHEKARNGNRSSTRSSSTKGKLELVDNKITTKKRSKSRSKERTRHRSDKK 199

Query: 352 SHNWSRNPSKE---RSHSHSRSSSKERDHRGSSSPRKESGRSQSGSPNKQRDHSRSRSPN 408
                    KE   RS S  R  SK    R  S  +    +S +     Q    ++RSP 
Sbjct: 200 KSKGGIEIVKEKTTRSKSKERKKSKSPSKRSKSQDQARKSKSPTLRRRSQEKIGKARSPT 259

Query: 409 KARDRSRSRSPYKARDRSRSRSPNKARDCSR---SRSPYKARDRSRSR-SPNKARDHSRS 464
             + +   +S  K++DR +S   N++R   R   SRSP   R +S+ R S +K R   RS
Sbjct: 260 DDKVKIEDKS--KSKDRKKSPIINESRSRDRGKKSRSPVDLRGKSKDRRSRSKERKSKRS 317

Query: 465 ---------RSPNK-----ARDRSRSRSPSKERDHSQLGSPSKERDHRRSRSPS-KERQC 509
                    +SP+K       +RS SR P +      L SP      RRSRSP   +R+ 
Sbjct: 318 ETDKEKKPIKSPSKDASSGKENRSPSRRPGRSPKRRSL-SPKPRDKSRRSRSPLLNDRRS 376

Query: 510 RQSRSSSKERDH-RRSRSPSKERQRRQSRSPNKERDRSQSRSPSEEREHRQSRS------ 562
           +QS+S S+     RR++S S ER+RR+   P + R  S    P ++   R+ RS      
Sbjct: 377 KQSKSPSRTLSPGRRAKSRSLERKRRE---PERRRLSSPRTRPRDDILSRRERSKDASPI 433

Query: 563 ----PSKERDRRRWRSPSKERERRQSRSSSEERDHSRSRSPNKQSGYSRPRASSKEKAHS 618
               P+    RRR RSP + R R   R S   R   RSRSP ++    R R+  + ++ S
Sbjct: 434 NRWSPT----RRRSRSPIRRRSRSPLRRSRSPR--RRSRSPRRRDRGRRSRSRLRRRSRS 487

Query: 619 RSRTPSKEGNHSQSRTSSKE 638
           R       G   +SR+  KE
Sbjct: 488 RG------GRRRRSRSKVKE 501



 Score =  103 bits (257), Expect = 6e-22
 Identities = 143/465 (30%), Positives = 221/465 (47%), Gaps = 66/465 (14%)

Query: 229 EKSDNPSPSSSRKVKSYGQMI-----IPSREKSYSPTEMSSRVKSYNQAS---------- 273
           EK+ N + SS+R   + G++      I ++++S S ++  +R +S  + S          
Sbjct: 152 EKARNGNRSSTRSSSTKGKLELVDNKITTKKRSKSRSKERTRHRSDKKKSKGGIEIVKEK 211

Query: 274 -TRSRPQSHSQSRSP-RRSRSGSQKRTHSRVRSHSWKRNHSRARSRTRKGILSQMGRHSQ 331
            TRS+ +   +S+SP +RS+S  Q R   + +S + +R       + R     ++    +
Sbjct: 212 TTRSKSKERKKSKSPSKRSKSQDQAR---KSKSPTLRRRSQEKIGKARSPTDDKVKIEDK 268

Query: 332 SRSHSKGKSQ--NQSRTPRRGRSHNWSRNPSKERSHSHSRSS-SKERDHRGSSSPRKES- 387
           S+S  + KS   N+SR+  RG+    SR+P   R  S  R S SKER  + S + +++  
Sbjct: 269 SKSKDRKKSPIINESRSRDRGKK---SRSPVDLRGKSKDRRSRSKERKSKRSETDKEKKP 325

Query: 388 --GRSQSGSPNKQRDHSRSRSPNKARDRSRSRSPYKARDRSR-SRSPN-KARDCSRSRSP 443
               S+  S  K+ + S SR P ++  R RS SP K RD+SR SRSP    R   +S+SP
Sbjct: 326 IKSPSKDASSGKE-NRSPSRRPGRSPKR-RSLSP-KPRDKSRRSRSPLLNDRRSKQSKSP 382

Query: 444 YKARD---RSRSRSPNKARDHSRSRSPNKARDRSRSRSPSKERDHSQLGSPSKERD--HR 498
            +      R++SRS  + R     R  +  R R R    S+ R+ S+  SP        R
Sbjct: 383 SRTLSPGRRAKSRSLERKRREPERRRLSSPRTRPRDDILSR-RERSKDASPINRWSPTRR 441

Query: 499 RSRSPSKERQCRQSRSSSKERDHRRSRSPSKERQRRQSRSPNKERDRSQSRSPSEEREHR 558
           RSRSP +    R+SRS       RRSRSP     RR+SRSP + RDR +    S  R  R
Sbjct: 442 RSRSPIR----RRSRSPL-----RRSRSP-----RRRSRSPRR-RDRGRR---SRSRLRR 483

Query: 559 QSRSPSKERDRRRWRSPSKERERRQSRSSSEERDHSRSRSPNKQSGYSRPRASSKEKAHS 618
           +SR  S+   RRR RS  KE + + S S   + +   S   N +           E+A  
Sbjct: 484 RSR--SRGGRRRRSRSKVKEDKFKGSLSEGMKVEQESSSDDNLE---DFDVEEEDEEALI 538

Query: 619 RSRTPSKEGNHSQSRTSSKESDPSQSTVPRSPDWKRSPTRTSSLS 663
             R   ++    + +  +++S+ S   VP  P   +S TRT S S
Sbjct: 539 EQRRIQRQAIVQKYKYLAEDSNMS---VPSEPSSPQSSTRTRSPS 580



 Score = 95.5 bits (236), Expect = 2e-19
 Identities = 115/462 (24%), Positives = 193/462 (41%), Gaps = 101/462 (21%)

Query: 316 SRTRKGILSQMGRHSQSRSHSKG----KSQNQSRTPRRGRSHNWSRNPSKERSHSHSRSS 371
           + + K I  + G  S+ +S +K     K +++ R+  +   H+   +  K+  H H    
Sbjct: 18  ANSEKSINEENGEVSEDQSQNKHSRHKKKKHKHRSKHKKHKHSSEEDKDKKHKHKHKHKK 77

Query: 372 SKER------DHRGSSSPRK--------------------------------ESGRS--- 390
            K +      D  G S  ++                                +SG     
Sbjct: 78  HKRKEIIDASDKEGMSPAKRTKLDDLALLEDLEKQRALIKAELDNELMEGKVQSGMGLIL 137

Query: 391 ---QSGSPNKQRDHSRSRSPNKARDRSRSRS------PYKARDRSRSRSPNKARDCSRSR 441
              +SGS  +   H ++R+ N++  RS S          K   + RS+S +K R   RS 
Sbjct: 138 QGYESGSEEEGEIHEKARNGNRSSTRSSSTKGKLELVDNKITTKKRSKSRSKERTRHRS- 196

Query: 442 SPYKARDRSRSRSPNKARDHSRSRSPNKARDRSRSRSPSKERDHSQLGSPSKERDHRR-- 499
                 D+ +S+   +      +RS  K+++R +S+SPSK          SK    RR  
Sbjct: 197 ------DKKKSKGGIEIVKEKTTRS--KSKERKKSKSPSKRSKSQDQARKSKSPTLRRRS 248

Query: 500 ------SRSPSKERQCRQSRSSSKERDHRRSRSPSKERQR-RQSRSPNKERDRSQS-RSP 551
                 +RSP+ ++   + +S SK+R      + S+ R R ++SRSP   R +S+  RS 
Sbjct: 249 QEKIGKARSPTDDKVKIEDKSKSKDRKKSPIINESRSRDRGKKSRSPVDLRGKSKDRRSR 308

Query: 552 SEEREHRQSRSPSKERDRRRWRSPSKERERRQSRSSSEERDHSR--SRSPNKQSGYSRPR 609
           S+ER+ ++S +   +++++  +SPSK+     + S  E R  SR   RSP ++S   +PR
Sbjct: 309 SKERKSKRSET---DKEKKPIKSPSKD-----ASSGKENRSPSRRPGRSPKRRSLSPKPR 360

Query: 610 ASSKEKAHSRSRTPSKEGNHS-QSRTSSKESDPSQSTVPRSPDWKRSPTRTSSLSQNRTP 668
             S+     RSR+P      S QS++ S+   P +    RS + KR           R P
Sbjct: 361 DKSR-----RSRSPLLNDRRSKQSKSPSRTLSPGRRAKSRSLERKR-----------REP 404

Query: 669 SKTSSHSPSTFPSGGQTLSQDDSQADATTSKATLPGERSSSS 710
            +    SP T P     LS+ +   DA+      P  R S S
Sbjct: 405 ERRRLSSPRTRPR-DDILSRRERSKDASPINRWSPTRRRSRS 445



 Score = 93.6 bits (231), Expect = 6e-19
 Identities = 155/612 (25%), Positives = 235/612 (38%), Gaps = 112/612 (18%)

Query: 50  ATSRNSVMSPSSSKSTKSTSTKRAPSNRPSSRSRVRSKARTPSRVSTDTRTSKASKASDV 109
           A S  S+   +   S   +  K   S     + + RSK +     S + +  K       
Sbjct: 18  ANSEKSINEENGEVSEDQSQNKH--SRHKKKKHKHRSKHKKHKHSSEEDKDKKHKHKHKH 75

Query: 110 RCHQRR----GTHSRGRTPGRRGSRSS---------KRSPSRASTPGRIRTHGARPGMAS 156
           + H+R+     +   G +P +R              +R+  +A     +     + GM  
Sbjct: 76  KKHKRKEIIDASDKEGMSPAKRTKLDDLALLEDLEKQRALIKAELDNELMEGKVQSGMGL 135

Query: 157 RVRTPTSQQKGSRGKSYGRPRTSNRERSDSQPRNLSKKSYRPPGGSGIGRSSELAVTPST 216
            ++   S  +   G+ + + R  NR    S  R+ S K              EL     T
Sbjct: 136 ILQGYESGSE-EEGEIHEKARNGNR----SSTRSSSTKG-----------KLELVDNKIT 179

Query: 217 AKCQTPTGIPSKEKSDNPSPSSSRKVKSYGQMII----------PSREKSYSPTEMSSRV 266
            K +      SK +S   +   S K KS G + I            R+KS SP   S R 
Sbjct: 180 TKKR------SKSRSKERTRHRSDKKKSKGGIEIVKEKTTRSKSKERKKSKSP---SKRS 230

Query: 267 KSYNQASTRSRPQSHSQS-------RSPRRSRSGSQKRTHSRVRSHSWKRNHSRARSRTR 319
           KS +QA     P    +S       RSP   +   + ++ S+ R  S   N SR+R R +
Sbjct: 231 KSQDQARKSKSPTLRRRSQEKIGKARSPTDDKVKIEDKSKSKDRKKSPIINESRSRDRGK 290

Query: 320 KGI--LSQMGRHSQSRSHSKGKSQNQSRTPRRGRSHNWSRNPSKERSHSHSRSSSKERDH 377
           K    +   G+    RS SK +   +S T +  +     ++PSK+ S      S   R  
Sbjct: 291 KSRSPVDLRGKSKDRRSRSKERKSKRSETDKEKKP---IKSPSKDASSGKENRSPSRRPG 347

Query: 378 RG------SSSPRKESGRSQSGSPNKQRDHSRSRSPNKARD---RSRSRSPYKAR---DR 425
           R       S  PR +S RS+S   N +R   +S+SP++      R++SRS  + R   +R
Sbjct: 348 RSPKRRSLSPKPRDKSRRSRSPLLNDRRS-KQSKSPSRTLSPGRRAKSRSLERKRREPER 406

Query: 426 SRSRSPN--------KARDCSRSRSPYK--ARDRSRSRSPNKARDHS---RSRSPNKARD 472
            R  SP           R+ S+  SP    +  R RSRSP + R  S   RSRSP + R 
Sbjct: 407 RRLSSPRTRPRDDILSRRERSKDASPINRWSPTRRRSRSPIRRRSRSPLRRSRSPRR-RS 465

Query: 473 RSRSRSPSKERDHSQLGSPSKERD--HRRSRSPSKERQCRQSRSSSKERDHRRSRSPSKE 530
           RS  R     R  S+L   S+ R    RRSRS  KE + + S S   + +   S   + E
Sbjct: 466 RSPRRRDRGRRSRSRLRRRSRSRGGRRRRSRSKVKEDKFKGSLSEGMKVEQESSSDDNLE 525

Query: 531 -------------RQRRQSRSP--------NKERDRSQSRSPSEEREHRQSRSPSKERDR 569
                         QRR  R           ++ + S    PS  +   ++RSPS +   
Sbjct: 526 DFDVEEEDEEALIEQRRIQRQAIVQKYKYLAEDSNMSVPSEPSSPQSSTRTRSPSPDDIL 585

Query: 570 RRWRSPSKERER 581
            R  +  KE ER
Sbjct: 586 ERVAADVKEYER 597



 Score = 77.4 bits (189), Expect = 4e-14
 Identities = 135/525 (25%), Positives = 191/525 (36%), Gaps = 115/525 (21%)

Query: 19  SSMPTADPKPPASLKSTKSATPNRSLVPTKPATSRNSVMSPSSS-------KSTKSTSTK 71
           SS  ++  K    L   K  T  RS   +K  T   S    S         K+T+S S +
Sbjct: 160 SSTRSSSTKGKLELVDNKITTKKRSKSRSKERTRHRSDKKKSKGGIEIVKEKTTRSKSKE 219

Query: 72  RAPSNRPSSRSRVRSKARTPSRVSTDTRT-SKASKASDVRCHQRRGTHSRGRTPGRRGSR 130
           R  S  PS RS+ + +AR     +   R+  K  KA       R  T  + +   +  S+
Sbjct: 220 RKKSKSPSKRSKSQDQARKSKSPTLRRRSQEKIGKA-------RSPTDDKVKIEDKSKSK 272

Query: 131 SSKRSPSRASTPGRIRTHGARPGMASRVRTPTSQQKGSRGKSYGRPRTSNRERSDSQPRN 190
             K+SP    +  R R          + R+P       RGKS  R R+ ++ER       
Sbjct: 273 DRKKSPIINESRSRDR--------GKKSRSPVD----LRGKSKDR-RSRSKERK------ 313

Query: 191 LSKKSYRPPGGSGIGRSSELAVTPSTAKCQTPTGIPSKEKSDNPSPSSSRKVKSYGQMII 250
            SK+S                    T K + P   PSK+ S      S            
Sbjct: 314 -SKRS-------------------ETDKEKKPIKSPSKDASSGKENRS------------ 341

Query: 251 PSREKSYSPTEMS----SRVKSYNQASTRSRPQSHSQSRSPRRSRSGSQK---RTHSRVR 303
           PSR    SP   S     R KS    S     +   QS+SP R+ S  ++   R+  R R
Sbjct: 342 PSRRPGRSPKRRSLSPKPRDKSRRSRSPLLNDRRSKQSKSPSRTLSPGRRAKSRSLERKR 401

Query: 304 SHSWKRNHSRARSRTRKGILSQMGRHSQSRSHSKGKSQNQSRTPRRGRSHNWSRNPSKER 363
               +R  S  R+R R  ILS+       R  SK  S     +P R R    SR+P + R
Sbjct: 402 REPERRRLSSPRTRPRDDILSR-------RERSKDASPINRWSPTRRR----SRSPIRRR 450

Query: 364 SHSHSRSSSKERDHRGSSSPRKESGRSQSGSPNKQRDHSRSRSPNKARDRSRSRSPYKAR 423
           S S  R S   R  R S SPR+             RD  R RS ++ R RSRSR   + R
Sbjct: 451 SRSPLRRSRSPR--RRSRSPRR-------------RDRGR-RSRSRLRRRSRSRGGRRRR 494

Query: 424 DRSRSRSPNKARDCSRSRSPYKARDRSRSRSPNKARDHSRSRSPNKARDRSRS------- 476
            RS+ +        S        +    S S +   D        +A    R        
Sbjct: 495 SRSKVKEDKFKGSLSEG-----MKVEQESSSDDNLEDFDVEEEDEEALIEQRRIQRQAIV 549

Query: 477 ---RSPSKERDHSQLGSPSKERDHRRSRSPSKERQCRQSRSSSKE 518
              +  +++ + S    PS  +   R+RSPS +    +  +  KE
Sbjct: 550 QKYKYLAEDSNMSVPSEPSSPQSSTRTRSPSPDDILERVAADVKE 594



 Score = 43.1 bits (100), Expect = 9e-04
 Identities = 43/148 (29%), Positives = 63/148 (42%), Gaps = 17/148 (11%)

Query: 3   SPKRSSKPSMSLAPSGSSMPTADPKPPASLKSTKSATPNRSLVPTKPATSRNSVMSPSSS 62
           SPK   K   S +P  +   +   K P+   S      +RSL   +    R  + SP + 
Sbjct: 356 SPKPRDKSRRSRSPLLNDRRSKQSKSPSRTLSPGRRAKSRSLERKRREPERRRLSSPRTR 415

Query: 63  K-----STKSTSTKRAPSNRPS-----SRSRVRSKARTPSRVS-TDTRTSKASKASDVRC 111
                 S +  S   +P NR S     SRS +R ++R+P R S +  R S++ +  D   
Sbjct: 416 PRDDILSRRERSKDASPINRWSPTRRRSRSPIRRRSRSPLRRSRSPRRRSRSPRRRD--- 472

Query: 112 HQRRGTHSRGRTPGRRGSRSSKRSPSRA 139
              RG  SR R   R  SR  +R  SR+
Sbjct: 473 ---RGRRSRSRLRRRSRSRGGRRRRSRS 497


>gi|145309302 cell division cycle 2-like 5 isoform 1 [Homo sapiens]
          Length = 1512

 Score =  104 bits (260), Expect = 2e-22
 Identities = 114/417 (27%), Positives = 163/417 (39%), Gaps = 58/417 (13%)

Query: 336 SKGKSQNQSRTPRRGRSHNWSRNPSKERSHSHSRSSSKERDHR-------GSSSPRKESG 388
           S G   + S T RRG      R P ++R  S  RS  + R+HR       GS + +  S 
Sbjct: 177 SGGSPASSSGTQRRGEGSE--RRPRRDRRSSSGRSKERHREHRRRDGQRGGSEASKSRSR 234

Query: 389 RSQSGSPNKQRDHSRSRSPNKARDRSRSRSPYKARDRSRSRSPNKARDCSRSRSPYKARD 448
            S SG    +   S S S +  R +S S +       S S S  K RD    RS  K+  
Sbjct: 235 HSHSGEERAEVAKSGSSSSSGGRRKSASAT-------SSSSSSRKDRDSKAHRSRTKSSK 287

Query: 449 RSRSRSPNKARDHSRSRSPNKARDRSRSRSPSKERDHSQLGSPSKERDHRRSRSPSKERQ 508
              S      + +   ++  KA  R RS SP   RD S +        HR S+S    + 
Sbjct: 288 EPPSAYKEPPKAYREDKTEPKAYRRRRSLSPLGGRDDSPVS-------HRASQSLRSRKS 340

Query: 509 CRQSRSSSKERDHRRSRSPSKERQRRQ---SRSPNKERDRSQSRSPSEEREHRQSRSPSK 565
              +   S     R  RSPS   +RR    SR  + ER    S SP      R+SRSP  
Sbjct: 341 PSPAGGGSSPYSRRLPRSPSPYSRRRSPSYSRHSSYERGGDVSPSPYSSSSWRRSRSPYS 400

Query: 566 ERDRRRWRSPSKE-RERRQSRSSSEERDHSRSRSPNKQSGYSRPRASSKEKAHSRSRTPS 624
              RR  +S S+     R SRS S  R  SRSRS +     S     S   A       +
Sbjct: 401 PVLRRSGKSRSRSPYSSRHSRSRSRHR-LSRSRSRHSSISPSTLTLKSSLAAELNKNKKA 459

Query: 625 KEGNHSQSRTSSKESDPSQSTVPRSPDWKRSPTRTSSLSQNRTPSKTS------------ 672
           +    +++  ++K ++ +++    +   K S T T +     T +  S            
Sbjct: 460 RAAEAARAAEAAKAAEATKAAEAAAKAAKASNTSTPTKGNTETSASASQTNHVKDVKKIK 519

Query: 673 -SHSPSTFPSGGQTLSQDDSQ---------------ADATTSKATLPGERSSSSSSK 713
             H+PS  PS G TL  D ++                D  T KA + G+ S S+++K
Sbjct: 520 IEHAPS--PSSGGTLKNDKAKTKPPLQVTKVENNLIVDKATKKAVIVGKESKSAATK 574



 Score = 80.5 bits (197), Expect = 5e-15
 Identities = 91/340 (26%), Positives = 134/340 (39%), Gaps = 51/340 (15%)

Query: 388 GRSQSGSPNKQRDHSRSRSPNKARDRSRSRSPYKARDRSRSRSPNKARDCSRSRSPYKAR 447
           G   S S  ++R     R P + R  S  RS  + R+  R        + S+SRS +   
Sbjct: 179 GSPASSSGTQRRGEGSERRPRRDRRSSSGRSKERHREHRRRDGQRGGSEASKSRSRHSHS 238

Query: 448 DRSRSRSPNKARDHSRSRSPNKARDRSRSRSPSKERDHSQLGSPSKERDHRRSRSPSKER 507
              R+     A+  S S S  + +  S + S S  R         K+RD +  RS +K  
Sbjct: 239 GEERAEV---AKSGSSSSSGGRRKSASATSSSSSSR---------KDRDSKAHRSRTKSS 286

Query: 508 QCRQSRSSSKERDHRRSRSPSKERQRRQSRSPNKERDRSQ-SRSPSEEREHRQSRSP--- 563
           +   S      + +R  ++  K  +RR+S SP   RD S  S   S+    R+S SP   
Sbjct: 287 KEPPSAYKEPPKAYREDKTEPKAYRRRRSLSPLGGRDDSPVSHRASQSLRSRKSPSPAGG 346

Query: 564 -SKERDRRRWRSPSKERERRQ---SRSSSEERDHSRSRSPNKQSGYSRPRASS----KEK 615
            S    RR  RSPS    RR    SR SS ER    S SP   S + R R+      +  
Sbjct: 347 GSSPYSRRLPRSPSPYSRRRSPSYSRHSSYERGGDVSPSPYSSSSWRRSRSPYSPVLRRS 406

Query: 616 AHSRSRTPSKEGNHSQSRTSSKESDPSQSTVPRSPDWKRSPTRTSSLSQNRTPSKTSSHS 675
             SRSR+P     HS+SR+  + S                          R+ S+ SS S
Sbjct: 407 GKSRSRSPYSS-RHSRSRSRHRLS--------------------------RSRSRHSSIS 439

Query: 676 PSTFPSGGQTLSQDDSQADATTSKATLPGERSSSSSSKLA 715
           PST        ++ +    A  ++A    E + ++ +  A
Sbjct: 440 PSTLTLKSSLAAELNKNKKARAAEAARAAEAAKAAEATKA 479



 Score = 65.5 bits (158), Expect = 2e-10
 Identities = 83/370 (22%), Positives = 150/370 (40%), Gaps = 27/370 (7%)

Query: 58  SPSSSKSTKST---STKRAPSNRPSSRSRVRSKARTPSRVSTDTRTSKASKASDVRCH-- 112
           SP+SS  T+     S +R   +R SS  R + + R   R       S+ASK+     H  
Sbjct: 180 SPASSSGTQRRGEGSERRPRRDRRSSSGRSKERHREHRRRDGQRGGSEASKSRSRHSHSG 239

Query: 113 QRRGTHSRGRTPGRRGSRSSKRSPSRASTPGRIRTHGARPGMASRVRTPTSQQKGSRGKS 172
           + R   ++  +    G R    S + +S+  R      R   A R RT +S++  S   +
Sbjct: 240 EERAEVAKSGSSSSSGGRRKSASATSSSSSSR----KDRDSKAHRSRTKSSKEPPS---A 292

Query: 173 YGRPRTSNRERSDSQPRNLSKKSYRPPGGSGIGRSSELA-VTPSTAKCQTPTGIPSKEKS 231
           Y  P  + RE          ++S  P GG      S  A  +  + K  +P G  S   S
Sbjct: 293 YKEPPKAYREDKTEPKAYRRRRSLSPLGGRDDSPVSHRASQSLRSRKSPSPAGGGSSPYS 352

Query: 232 ----DNPSPSSSRKVKSYGQMIIPSR--EKSYSPTEMSSRVKSYNQASTRSRPQSHSQSR 285
                +PSP S R+  SY +     R  + S SP   SS  +S +  S   R    S+SR
Sbjct: 353 RRLPRSPSPYSRRRSPSYSRHSSYERGGDVSPSPYSSSSWRRSRSPYSPVLRRSGKSRSR 412

Query: 286 SPRRSRSGSQKRTHSRVRSHSWKRNHSRARSRTRKGILSQMGRHSQSRSHSKGKSQNQSR 345
           SP  SR    +  H   RS S   + S +    +  + +++ ++ ++R+    ++   ++
Sbjct: 413 SPYSSRHSRSRSRHRLSRSRSRHSSISPSTLTLKSSLAAELNKNKKARAAEAARAAEAAK 472

Query: 346 TPR-------RGRSHNWSRNPSKERSHSHSRSSSKERDH-RGSSSPRKESGRSQSGSPNK 397
                       ++   S   +  + ++ + +S+ + +H +     + E   S S     
Sbjct: 473 AAEATKAAEAAAKAAKASNTSTPTKGNTETSASASQTNHVKDVKKIKIEHAPSPSSGGTL 532

Query: 398 QRDHSRSRSP 407
           + D ++++ P
Sbjct: 533 KNDKAKTKPP 542



 Score = 63.9 bits (154), Expect = 5e-10
 Identities = 106/425 (24%), Positives = 165/425 (38%), Gaps = 56/425 (13%)

Query: 128 GSRSSKRSPSRASTPGRIRTHGARPGMASRVRTPTSQQKGSRGKSYGRPRTSNRERSDSQ 187
           G+  S  SP+ +S   R R  G+        R P   ++ S G+S  R R  +R R   +
Sbjct: 173 GTGGSGGSPASSSGTQR-RGEGSE-------RRPRRDRRSSSGRSKERHR-EHRRRDGQR 223

Query: 188 PRNLSKKSYRPPGGSGIGRSSELAVTPSTAKCQTPTGIPSKEKSDNPSPSSSRKVKSYGQ 247
             + + KS      SG  R+ E+A + S++     +G   K  S   S SSSRK +    
Sbjct: 224 GGSEASKSRSRHSHSGEERA-EVAKSGSSSS----SGGRRKSASATSSSSSSRKDRDSKA 278

Query: 248 MIIPSREKSYSPTEMSSRVKSYNQASTRSRPQSHSQSRSPRRSRSGSQKRTHSRVRSHSW 307
               ++     P+      K+Y +  T  +     +S SP   R  S         SH  
Sbjct: 279 HRSRTKSSKEPPSAYKEPPKAYREDKTEPKAYRRRRSLSPLGGRDDSPV-------SHR- 330

Query: 308 KRNHSRARSRTRKGILSQMGRHSQSRSHSKGKSQNQSRTPRRGRSHNWSRNPSKERSHSH 367
                           SQ  R  +S S + G S   SR   R  S       S+ RS S+
Sbjct: 331 ---------------ASQSLRSRKSPSPAGGGSSPYSRRLPRSPSPY-----SRRRSPSY 370

Query: 368 SRSSSKERDHRGSSSPRKESGRSQSGSPNKQRDHSRSRSPNKARD-RSRSRSPYKARDRS 426
           SR SS ER    S SP   S   +S SP          SP   R  +SRSRSPY +R  S
Sbjct: 371 SRHSSYERGGDVSPSPYSSSSWRRSRSP---------YSPVLRRSGKSRSRSPYSSR-HS 420

Query: 427 RSRSPNKARDCSRSRSPYKARDRSRSRSPNKARDHSRSRSPNKARDRSRSRSPSKERDHS 486
           RSRS ++    SRSRS + +   S     +            +A + +R+   +K  + +
Sbjct: 421 RSRSRHR---LSRSRSRHSSISPSTLTLKSSLAAELNKNKKARAAEAARAAEAAKAAEAT 477

Query: 487 QLGSPSKERDHRRSRSPSKERQCRQSRSSSKERDHRRSRSPSKERQRRQSRSPNKERDRS 546
           +    + +     + S   +     S S+S+    +  +    E     S     + D++
Sbjct: 478 KAAEAAAKAAKASNTSTPTKGNTETSASASQTNHVKDVKKIKIEHAPSPSSGGTLKNDKA 537

Query: 547 QSRSP 551
           +++ P
Sbjct: 538 KTKPP 542



 Score = 39.7 bits (91), Expect = 0.010
 Identities = 57/249 (22%), Positives = 94/249 (37%), Gaps = 26/249 (10%)

Query: 48  KPATSRNSVMSPSSSKSTKSTSTKRAPSNRPSSRSRVRSKARTPSRVSTDTRTSKASKAS 107
           K  +S +S     S+ +T S+S+ R   +  + RSR +S    PS      +  +  K  
Sbjct: 247 KSGSSSSSGGRRKSASATSSSSSSRKDRDSKAHRSRTKSSKEPPSAYKEPPKAYREDKTE 306

Query: 108 DVRCHQRRGTHSRGRTPGRRGSRSSKRSPSRASTPGRIRTHGARPGMASRVRTPTSQQKG 167
                +RR     G   GR  S  S R+     +       G      SR R P S    
Sbjct: 307 PKAYRRRRSLSPLG---GRDDSPVSHRASQSLRSRKSPSPAGGGSSPYSR-RLPRSPSPY 362

Query: 168 SRGKSYGRPRTSNRER-SDSQPRNLSKKSYRPPGGSGIGRSSELAVTPSTAKCQTPTGIP 226
           SR +S    R S+ ER  D  P   S  S+         R S    +P   +        
Sbjct: 363 SRRRSPSYSRHSSYERGGDVSPSPYSSSSW---------RRSRSPYSPVLRR-------- 405

Query: 227 SKEKSDNPSPSSSRKVKSYGQMIIP---SREKSYSPTEMSSRVKSYNQASTRSRPQSHSQ 283
              KS + SP SSR  +S  +  +    SR  S SP+ ++ +     + +   + ++   
Sbjct: 406 -SGKSRSRSPYSSRHSRSRSRHRLSRSRSRHSSISPSTLTLKSSLAAELNKNKKARAAEA 464

Query: 284 SRSPRRSRS 292
           +R+   +++
Sbjct: 465 ARAAEAAKA 473



 Score = 38.5 bits (88), Expect = 0.022
 Identities = 52/198 (26%), Positives = 77/198 (38%), Gaps = 24/198 (12%)

Query: 2   SSPKRSSKPSMSLAPSGSSMPTADPKPPASLKSTKSATP----NRSLVPTKPATSRNSVM 57
           S   R SK   S   S    P+A  +PP + +  K+        RSL    P   R+   
Sbjct: 270 SRKDRDSKAHRSRTKSSKEPPSAYKEPPKAYREDKTEPKAYRRRRSL---SPLGGRDD-- 324

Query: 58  SPSSSKSTKSTSTKRAPSNRPSSRSRVRSKARTPSRVSTDTRTSKASKASDVRCHQRRGT 117
           SP S ++++S  ++++PS  P+         R P   S  +R    S       + R  +
Sbjct: 325 SPVSHRASQSLRSRKSPS--PAGGGSSPYSRRLPRSPSPYSRRRSPS-------YSRHSS 375

Query: 118 HSRGRTPGRRGSRSSKRSPSRASTPGRIRTHGARPGMASRVRTPTSQQKGSRGKSYGRPR 177
           + RG         SS    SR+     +R  G      SR R+P S  + SR +S  R  
Sbjct: 376 YERGGDVSPSPYSSSSWRRSRSPYSPVLRRSG-----KSRSRSPYS-SRHSRSRSRHRLS 429

Query: 178 TSNRERSDSQPRNLSKKS 195
            S    S   P  L+ KS
Sbjct: 430 RSRSRHSSISPSTLTLKS 447


>gi|145309300 cell division cycle 2-like 5 isoform 2 [Homo sapiens]
          Length = 1452

 Score =  104 bits (260), Expect = 2e-22
 Identities = 114/417 (27%), Positives = 163/417 (39%), Gaps = 58/417 (13%)

Query: 336 SKGKSQNQSRTPRRGRSHNWSRNPSKERSHSHSRSSSKERDHR-------GSSSPRKESG 388
           S G   + S T RRG      R P ++R  S  RS  + R+HR       GS + +  S 
Sbjct: 177 SGGSPASSSGTQRRGEGSE--RRPRRDRRSSSGRSKERHREHRRRDGQRGGSEASKSRSR 234

Query: 389 RSQSGSPNKQRDHSRSRSPNKARDRSRSRSPYKARDRSRSRSPNKARDCSRSRSPYKARD 448
            S SG    +   S S S +  R +S S +       S S S  K RD    RS  K+  
Sbjct: 235 HSHSGEERAEVAKSGSSSSSGGRRKSASAT-------SSSSSSRKDRDSKAHRSRTKSSK 287

Query: 449 RSRSRSPNKARDHSRSRSPNKARDRSRSRSPSKERDHSQLGSPSKERDHRRSRSPSKERQ 508
              S      + +   ++  KA  R RS SP   RD S +        HR S+S    + 
Sbjct: 288 EPPSAYKEPPKAYREDKTEPKAYRRRRSLSPLGGRDDSPVS-------HRASQSLRSRKS 340

Query: 509 CRQSRSSSKERDHRRSRSPSKERQRRQ---SRSPNKERDRSQSRSPSEEREHRQSRSPSK 565
              +   S     R  RSPS   +RR    SR  + ER    S SP      R+SRSP  
Sbjct: 341 PSPAGGGSSPYSRRLPRSPSPYSRRRSPSYSRHSSYERGGDVSPSPYSSSSWRRSRSPYS 400

Query: 566 ERDRRRWRSPSKE-RERRQSRSSSEERDHSRSRSPNKQSGYSRPRASSKEKAHSRSRTPS 624
              RR  +S S+     R SRS S  R  SRSRS +     S     S   A       +
Sbjct: 401 PVLRRSGKSRSRSPYSSRHSRSRSRHR-LSRSRSRHSSISPSTLTLKSSLAAELNKNKKA 459

Query: 625 KEGNHSQSRTSSKESDPSQSTVPRSPDWKRSPTRTSSLSQNRTPSKTS------------ 672
           +    +++  ++K ++ +++    +   K S T T +     T +  S            
Sbjct: 460 RAAEAARAAEAAKAAEATKAAEAAAKAAKASNTSTPTKGNTETSASASQTNHVKDVKKIK 519

Query: 673 -SHSPSTFPSGGQTLSQDDSQ---------------ADATTSKATLPGERSSSSSSK 713
             H+PS  PS G TL  D ++                D  T KA + G+ S S+++K
Sbjct: 520 IEHAPS--PSSGGTLKNDKAKTKPPLQVTKVENNLIVDKATKKAVIVGKESKSAATK 574



 Score = 80.5 bits (197), Expect = 5e-15
 Identities = 91/340 (26%), Positives = 134/340 (39%), Gaps = 51/340 (15%)

Query: 388 GRSQSGSPNKQRDHSRSRSPNKARDRSRSRSPYKARDRSRSRSPNKARDCSRSRSPYKAR 447
           G   S S  ++R     R P + R  S  RS  + R+  R        + S+SRS +   
Sbjct: 179 GSPASSSGTQRRGEGSERRPRRDRRSSSGRSKERHREHRRRDGQRGGSEASKSRSRHSHS 238

Query: 448 DRSRSRSPNKARDHSRSRSPNKARDRSRSRSPSKERDHSQLGSPSKERDHRRSRSPSKER 507
              R+     A+  S S S  + +  S + S S  R         K+RD +  RS +K  
Sbjct: 239 GEERAEV---AKSGSSSSSGGRRKSASATSSSSSSR---------KDRDSKAHRSRTKSS 286

Query: 508 QCRQSRSSSKERDHRRSRSPSKERQRRQSRSPNKERDRSQ-SRSPSEEREHRQSRSP--- 563
           +   S      + +R  ++  K  +RR+S SP   RD S  S   S+    R+S SP   
Sbjct: 287 KEPPSAYKEPPKAYREDKTEPKAYRRRRSLSPLGGRDDSPVSHRASQSLRSRKSPSPAGG 346

Query: 564 -SKERDRRRWRSPSKERERRQ---SRSSSEERDHSRSRSPNKQSGYSRPRASS----KEK 615
            S    RR  RSPS    RR    SR SS ER    S SP   S + R R+      +  
Sbjct: 347 GSSPYSRRLPRSPSPYSRRRSPSYSRHSSYERGGDVSPSPYSSSSWRRSRSPYSPVLRRS 406

Query: 616 AHSRSRTPSKEGNHSQSRTSSKESDPSQSTVPRSPDWKRSPTRTSSLSQNRTPSKTSSHS 675
             SRSR+P     HS+SR+  + S                          R+ S+ SS S
Sbjct: 407 GKSRSRSPYSS-RHSRSRSRHRLS--------------------------RSRSRHSSIS 439

Query: 676 PSTFPSGGQTLSQDDSQADATTSKATLPGERSSSSSSKLA 715
           PST        ++ +    A  ++A    E + ++ +  A
Sbjct: 440 PSTLTLKSSLAAELNKNKKARAAEAARAAEAAKAAEATKA 479



 Score = 65.5 bits (158), Expect = 2e-10
 Identities = 83/370 (22%), Positives = 150/370 (40%), Gaps = 27/370 (7%)

Query: 58  SPSSSKSTKST---STKRAPSNRPSSRSRVRSKARTPSRVSTDTRTSKASKASDVRCH-- 112
           SP+SS  T+     S +R   +R SS  R + + R   R       S+ASK+     H  
Sbjct: 180 SPASSSGTQRRGEGSERRPRRDRRSSSGRSKERHREHRRRDGQRGGSEASKSRSRHSHSG 239

Query: 113 QRRGTHSRGRTPGRRGSRSSKRSPSRASTPGRIRTHGARPGMASRVRTPTSQQKGSRGKS 172
           + R   ++  +    G R    S + +S+  R      R   A R RT +S++  S   +
Sbjct: 240 EERAEVAKSGSSSSSGGRRKSASATSSSSSSR----KDRDSKAHRSRTKSSKEPPS---A 292

Query: 173 YGRPRTSNRERSDSQPRNLSKKSYRPPGGSGIGRSSELA-VTPSTAKCQTPTGIPSKEKS 231
           Y  P  + RE          ++S  P GG      S  A  +  + K  +P G  S   S
Sbjct: 293 YKEPPKAYREDKTEPKAYRRRRSLSPLGGRDDSPVSHRASQSLRSRKSPSPAGGGSSPYS 352

Query: 232 ----DNPSPSSSRKVKSYGQMIIPSR--EKSYSPTEMSSRVKSYNQASTRSRPQSHSQSR 285
                +PSP S R+  SY +     R  + S SP   SS  +S +  S   R    S+SR
Sbjct: 353 RRLPRSPSPYSRRRSPSYSRHSSYERGGDVSPSPYSSSSWRRSRSPYSPVLRRSGKSRSR 412

Query: 286 SPRRSRSGSQKRTHSRVRSHSWKRNHSRARSRTRKGILSQMGRHSQSRSHSKGKSQNQSR 345
           SP  SR    +  H   RS S   + S +    +  + +++ ++ ++R+    ++   ++
Sbjct: 413 SPYSSRHSRSRSRHRLSRSRSRHSSISPSTLTLKSSLAAELNKNKKARAAEAARAAEAAK 472

Query: 346 TPR-------RGRSHNWSRNPSKERSHSHSRSSSKERDH-RGSSSPRKESGRSQSGSPNK 397
                       ++   S   +  + ++ + +S+ + +H +     + E   S S     
Sbjct: 473 AAEATKAAEAAAKAAKASNTSTPTKGNTETSASASQTNHVKDVKKIKIEHAPSPSSGGTL 532

Query: 398 QRDHSRSRSP 407
           + D ++++ P
Sbjct: 533 KNDKAKTKPP 542



 Score = 63.9 bits (154), Expect = 5e-10
 Identities = 106/425 (24%), Positives = 165/425 (38%), Gaps = 56/425 (13%)

Query: 128 GSRSSKRSPSRASTPGRIRTHGARPGMASRVRTPTSQQKGSRGKSYGRPRTSNRERSDSQ 187
           G+  S  SP+ +S   R R  G+        R P   ++ S G+S  R R  +R R   +
Sbjct: 173 GTGGSGGSPASSSGTQR-RGEGSE-------RRPRRDRRSSSGRSKERHR-EHRRRDGQR 223

Query: 188 PRNLSKKSYRPPGGSGIGRSSELAVTPSTAKCQTPTGIPSKEKSDNPSPSSSRKVKSYGQ 247
             + + KS      SG  R+ E+A + S++     +G   K  S   S SSSRK +    
Sbjct: 224 GGSEASKSRSRHSHSGEERA-EVAKSGSSSS----SGGRRKSASATSSSSSSRKDRDSKA 278

Query: 248 MIIPSREKSYSPTEMSSRVKSYNQASTRSRPQSHSQSRSPRRSRSGSQKRTHSRVRSHSW 307
               ++     P+      K+Y +  T  +     +S SP   R  S         SH  
Sbjct: 279 HRSRTKSSKEPPSAYKEPPKAYREDKTEPKAYRRRRSLSPLGGRDDSPV-------SHR- 330

Query: 308 KRNHSRARSRTRKGILSQMGRHSQSRSHSKGKSQNQSRTPRRGRSHNWSRNPSKERSHSH 367
                           SQ  R  +S S + G S   SR   R  S       S+ RS S+
Sbjct: 331 ---------------ASQSLRSRKSPSPAGGGSSPYSRRLPRSPSPY-----SRRRSPSY 370

Query: 368 SRSSSKERDHRGSSSPRKESGRSQSGSPNKQRDHSRSRSPNKARD-RSRSRSPYKARDRS 426
           SR SS ER    S SP   S   +S SP          SP   R  +SRSRSPY +R  S
Sbjct: 371 SRHSSYERGGDVSPSPYSSSSWRRSRSP---------YSPVLRRSGKSRSRSPYSSR-HS 420

Query: 427 RSRSPNKARDCSRSRSPYKARDRSRSRSPNKARDHSRSRSPNKARDRSRSRSPSKERDHS 486
           RSRS ++    SRSRS + +   S     +            +A + +R+   +K  + +
Sbjct: 421 RSRSRHR---LSRSRSRHSSISPSTLTLKSSLAAELNKNKKARAAEAARAAEAAKAAEAT 477

Query: 487 QLGSPSKERDHRRSRSPSKERQCRQSRSSSKERDHRRSRSPSKERQRRQSRSPNKERDRS 546
           +    + +     + S   +     S S+S+    +  +    E     S     + D++
Sbjct: 478 KAAEAAAKAAKASNTSTPTKGNTETSASASQTNHVKDVKKIKIEHAPSPSSGGTLKNDKA 537

Query: 547 QSRSP 551
           +++ P
Sbjct: 538 KTKPP 542



 Score = 39.7 bits (91), Expect = 0.010
 Identities = 57/249 (22%), Positives = 94/249 (37%), Gaps = 26/249 (10%)

Query: 48  KPATSRNSVMSPSSSKSTKSTSTKRAPSNRPSSRSRVRSKARTPSRVSTDTRTSKASKAS 107
           K  +S +S     S+ +T S+S+ R   +  + RSR +S    PS      +  +  K  
Sbjct: 247 KSGSSSSSGGRRKSASATSSSSSSRKDRDSKAHRSRTKSSKEPPSAYKEPPKAYREDKTE 306

Query: 108 DVRCHQRRGTHSRGRTPGRRGSRSSKRSPSRASTPGRIRTHGARPGMASRVRTPTSQQKG 167
                +RR     G   GR  S  S R+     +       G      SR R P S    
Sbjct: 307 PKAYRRRRSLSPLG---GRDDSPVSHRASQSLRSRKSPSPAGGGSSPYSR-RLPRSPSPY 362

Query: 168 SRGKSYGRPRTSNRER-SDSQPRNLSKKSYRPPGGSGIGRSSELAVTPSTAKCQTPTGIP 226
           SR +S    R S+ ER  D  P   S  S+         R S    +P   +        
Sbjct: 363 SRRRSPSYSRHSSYERGGDVSPSPYSSSSW---------RRSRSPYSPVLRR-------- 405

Query: 227 SKEKSDNPSPSSSRKVKSYGQMIIP---SREKSYSPTEMSSRVKSYNQASTRSRPQSHSQ 283
              KS + SP SSR  +S  +  +    SR  S SP+ ++ +     + +   + ++   
Sbjct: 406 -SGKSRSRSPYSSRHSRSRSRHRLSRSRSRHSSISPSTLTLKSSLAAELNKNKKARAAEA 464

Query: 284 SRSPRRSRS 292
           +R+   +++
Sbjct: 465 ARAAEAAKA 473



 Score = 38.5 bits (88), Expect = 0.022
 Identities = 52/198 (26%), Positives = 77/198 (38%), Gaps = 24/198 (12%)

Query: 2   SSPKRSSKPSMSLAPSGSSMPTADPKPPASLKSTKSATP----NRSLVPTKPATSRNSVM 57
           S   R SK   S   S    P+A  +PP + +  K+        RSL    P   R+   
Sbjct: 270 SRKDRDSKAHRSRTKSSKEPPSAYKEPPKAYREDKTEPKAYRRRRSL---SPLGGRDD-- 324

Query: 58  SPSSSKSTKSTSTKRAPSNRPSSRSRVRSKARTPSRVSTDTRTSKASKASDVRCHQRRGT 117
           SP S ++++S  ++++PS  P+         R P   S  +R    S       + R  +
Sbjct: 325 SPVSHRASQSLRSRKSPS--PAGGGSSPYSRRLPRSPSPYSRRRSPS-------YSRHSS 375

Query: 118 HSRGRTPGRRGSRSSKRSPSRASTPGRIRTHGARPGMASRVRTPTSQQKGSRGKSYGRPR 177
           + RG         SS    SR+     +R  G      SR R+P S  + SR +S  R  
Sbjct: 376 YERGGDVSPSPYSSSSWRRSRSPYSPVLRRSG-----KSRSRSPYS-SRHSRSRSRHRLS 429

Query: 178 TSNRERSDSQPRNLSKKS 195
            S    S   P  L+ KS
Sbjct: 430 RSRSRHSSISPSTLTLKS 447


>gi|239757964 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 290

 Score =  103 bits (258), Expect = 4e-22
 Identities = 62/235 (26%), Positives = 105/235 (44%), Gaps = 10/235 (4%)

Query: 375 RDHRGSSSPRKESGRSQS----GSPNKQRDHSRSRSPN-KARDRSRSRSPYKARDRSRSR 429
           R   GS    +  G  Q+       ++QR+  R R    K RDR R R   + R   + +
Sbjct: 51  RGRLGSQESPRSWGLGQAHKDADGDDRQRERDRVREKTEKERDRDRKRDRERRR---KEK 107

Query: 430 SPNKARDCSRSRSPYKARDRSRSRSPNKARDHSRSRSPNKARDRSRSRSPSKERDHSQLG 489
             N+ RD  +     + R+R + +   + RD  R R  ++ R++ R R   K+RD  +  
Sbjct: 108 ETNRNRDREKQTEIERDREREKQKGRERERDRGRERERDRDREKERERQTEKDRDGQRET 167

Query: 490 SPSKERDHRRSRSPSKERQCRQSRSSSKERDHRRSRSPSKERQRRQSRSPNKERDRSQSR 549
              +ERD  R +   +E +  + R    E++  R     ++RQR+      +E DR   R
Sbjct: 168 ETERERDREREKQKERETERDRDRQRDTEKERERQTDRERDRQRKTQTERQRETDREGER 227

Query: 550 SPSEEREHRQSRSPSKERDRRRWRSPSKERERRQSRSS--SEERDHSRSRSPNKQ 602
                RE ++ R   KERDR R R   +++ER++ R     E++   + R   K+
Sbjct: 228 ETDRRRERQRDRDRGKERDRERDRKEERKKERKKERKKERKEKKKEEKRREDKKR 282



 Score =  101 bits (251), Expect = 3e-21
 Identities = 70/266 (26%), Positives = 115/266 (43%), Gaps = 36/266 (13%)

Query: 336 SKGK--SQNQSRTPRRGRSHNWSRNPSKERSHSHSRSSS-KERDHRGSSSPRKESGRSQS 392
           S+G+  SQ   R+   G++H  +    ++R     R  + KERD                
Sbjct: 50  SRGRLGSQESPRSWGLGQAHKDADGDDRQRERDRVREKTEKERDR--------------- 94

Query: 393 GSPNKQRDHSRSRSPNKA-RDRSRSRSPYKARDRSRSRSPNKARDCSRSRSPYKARDRSR 451
              +++RD  R R   +  R+R R +     RDR R +   + R+  R R   + RDR +
Sbjct: 95  ---DRKRDRERRRKEKETNRNRDREKQTEIERDREREKQKGRERERDRGRERERDRDREK 151

Query: 452 SRSPNKARDHSRSRSPNKARDRSRSRSPSKERDHSQLGSPSKERDHRRSRSPSKERQCRQ 511
            R     +D    R     R+R R R   KER+         ERD  R R   KER+   
Sbjct: 152 ERERQTEKDRDGQRETETERERDREREKQKERE--------TERDRDRQRDTEKERE--- 200

Query: 512 SRSSSKERDHRRSRSPSKERQRRQSRSPNKERDRSQSRSPSEEREHRQSRSPSKERDRRR 571
            R + +ERD  R R    ERQR   R   +E DR + R    +R   + R   ++ +R++
Sbjct: 201 -RQTDRERD--RQRKTQTERQRETDREGERETDRRRERQRDRDRGKERDRERDRKEERKK 257

Query: 572 WRSPSKERERRQSRSSSEERDHSRSR 597
            R   +++ER++ +   + R+  + +
Sbjct: 258 ERKKERKKERKEKKKEEKRREDKKRK 283



 Score = 94.7 bits (234), Expect = 3e-19
 Identities = 60/241 (24%), Positives = 106/241 (43%), Gaps = 10/241 (4%)

Query: 400 DHSRSRSPNKARDRSRSRSPYKARDRSRSRSPNKARDCSRSRSPYKARDRSRSRSPNKAR 459
           D SR R  ++   RS      +A   +      + RD  R ++  K RDR R R   + R
Sbjct: 48  DFSRGRLGSQESPRSWGLG--QAHKDADGDDRQRERDRVREKTE-KERDRDRKRDRERRR 104

Query: 460 DHSRSRSPNKARDRSRSRSPSKERDHSQLGSPSKERDHRRSRSPSKERQCRQSRSSSKER 519
              + +  N+ RDR +     ++R+  +     +ERD  R R   ++R+  + R + K+R
Sbjct: 105 ---KEKETNRNRDREKQTEIERDREREKQKGRERERDRGRERERDRDREKERERQTEKDR 161

Query: 520 DHRRSRSPSKERQRRQSRSPNKERDRSQSRSPSEEREHRQSRSPSKERDRRRWRSPSKER 579
           D +R     +ER R + +   +E +R + R    E+E  + R   +ERDR+  R    ER
Sbjct: 162 DGQRETETERERDREREKQKERETERDRDRQRDTEKE--RERQTDRERDRQ--RKTQTER 217

Query: 580 ERRQSRSSSEERDHSRSRSPNKQSGYSRPRASSKEKAHSRSRTPSKEGNHSQSRTSSKES 639
           +R   R    E D  R R  ++  G  R R   +++   + R   ++    + +   K  
Sbjct: 218 QRETDREGERETDRRRERQRDRDRGKERDRERDRKEERKKERKKERKKERKEKKKEEKRR 277

Query: 640 D 640
           +
Sbjct: 278 E 278



 Score = 89.7 bits (221), Expect = 8e-18
 Identities = 60/248 (24%), Positives = 104/248 (41%), Gaps = 19/248 (7%)

Query: 325 QMGRHSQSRSHSKGKSQNQSRTPRRGRSHNWSRNPS-KERSHSHSRSSSKERDHRGSSSP 383
           ++G     RS   G++   +    R R  +  R  + KER     R   + R  + ++  
Sbjct: 53  RLGSQESPRSWGLGQAHKDADGDDRQRERDRVREKTEKERDRDRKRDRERRRKEKETNRN 112

Query: 384 RK-------ESGRSQSGSPNKQRDHSRSRSPNKARDRSRSRSPYKARDRSRSRSPNKARD 436
           R        E  R +     ++R+  R R   + RDR + R     +DR   R     R+
Sbjct: 113 RDREKQTEIERDREREKQKGRERERDRGRERERDRDREKERERQTEKDRDGQRETETERE 172

Query: 437 CSRSRSPYKARDRSRSRSPNKARDHSRSRSPNKARDRSRSRSPSKERDHSQLGSPSKERD 496
             R R   K R+  R R   +  +  R R  ++ RDR R     ++R+  + G   +E D
Sbjct: 173 RDREREKQKERETERDRDRQRDTEKERERQTDRERDRQRKTQTERQRETDREGE--RETD 230

Query: 497 HRRSRSPSKERQCRQSRSSSKERDHRRSRSPSKERQRRQSR-SPNKERDRSQSRSPSEER 555
            RR R   ++R         KERD  R R   ++++R++ R    KE+ + + R   ++R
Sbjct: 231 RRRERQRDRDR--------GKERDRERDRKEERKKERKKERKKERKEKKKEEKRREDKKR 282

Query: 556 EHRQSRSP 563
           +  +  SP
Sbjct: 283 KWGEGISP 290



 Score = 87.0 bits (214), Expect = 5e-17
 Identities = 57/239 (23%), Positives = 99/239 (41%), Gaps = 6/239 (2%)

Query: 416 SRSPYKARDRSRSRSPNKARDCSRSRSPYKARDRSRSRSPNKARDHSRSRSPNKARDRSR 475
           SR    +++  RS    +A   +      + RDR R ++  K RD  R R   + R   +
Sbjct: 50  SRGRLGSQESPRSWGLGQAHKDADGDDRQRERDRVREKT-EKERDRDRKRDRERRR---K 105

Query: 476 SRSPSKERDHSQLGSPSKERDHRRSRSPSKERQCRQSRSSSKERDHRRSRSPSKERQRRQ 535
            +  ++ RD  +      ERD  R +   +ER+  + R   ++RD  + R    E+ R  
Sbjct: 106 EKETNRNRDREK--QTEIERDREREKQKGRERERDRGRERERDRDREKERERQTEKDRDG 163

Query: 536 SRSPNKERDRSQSRSPSEEREHRQSRSPSKERDRRRWRSPSKERERRQSRSSSEERDHSR 595
            R    ER+R + R   +ERE  + R   ++ ++ R R   +ER+R++   +  +R+  R
Sbjct: 164 QRETETERERDREREKQKERETERDRDRQRDTEKERERQTDRERDRQRKTQTERQRETDR 223

Query: 596 SRSPNKQSGYSRPRASSKEKAHSRSRTPSKEGNHSQSRTSSKESDPSQSTVPRSPDWKR 654
                      R R   + K   R R   +E    + +   KE    +    R  D KR
Sbjct: 224 EGERETDRRRERQRDRDRGKERDRERDRKEERKKERKKERKKERKEKKKEEKRREDKKR 282



 Score = 80.9 bits (198), Expect = 4e-15
 Identities = 65/274 (23%), Positives = 111/274 (40%), Gaps = 35/274 (12%)

Query: 268 SYNQASTRSRPQSHSQSRSPRRSRSGSQKRTHSRVRSHSWKRNHSRARSRTRKGILSQMG 327
           S  +  ++  P+S    ++ + +    ++R   RVR  + K      R R RK       
Sbjct: 50  SRGRLGSQESPRSWGLGQAHKDADGDDRQRERDRVREKTEKE-----RDRDRK------- 97

Query: 328 RHSQSRSHSKGKSQNQSRTPRRGRSHNWSRNPSKERSHSHSRSSSKERDHRGSSSPRKES 387
           R  + R   K  ++N+ R  +     +  R   K R     R   +ERD        ++ 
Sbjct: 98  RDRERRRKEKETNRNRDREKQTEIERDREREKQKGRERERDRGRERERD--------RDR 149

Query: 388 GRSQSGSPNKQRDHSRSRSPNKARDRSRSRSPYKARDRSRSRSPNKARDCSRSRSPYKAR 447
            + +     K RD  R     + RDR R +   K R+  R R   +  +  R R   + R
Sbjct: 150 EKERERQTEKDRDGQRETETERERDREREKQ--KERETERDRDRQRDTEKERERQTDRER 207

Query: 448 DRSRSRSPNKARDHSR--SRSPNKARDRSRSRSPSKERDHSQLGSPSKERDHRRSRSPSK 505
           DR R     + R+  R   R  ++ R+R R R   KERD        +ERD +  R   +
Sbjct: 208 DRQRKTQTERQRETDREGERETDRRRERQRDRDRGKERD--------RERDRKEERKKER 259

Query: 506 ERQCRQSRSSSKERDHRRSRSPSKERQRRQSRSP 539
           +++ ++ R   K+ + RR     K+R+  +  SP
Sbjct: 260 KKERKKERKEKKKEEKRRE---DKKRKWGEGISP 290



 Score = 80.1 bits (196), Expect = 7e-15
 Identities = 52/243 (21%), Positives = 101/243 (41%), Gaps = 12/243 (4%)

Query: 428 SRSPNKARDCSRSRSPYKARDRSRSRSPNKARDHSRSRSPNKARDRSRSRSPSKERDHSQ 487
           SR    +++  RS    +A   +      + RD  R ++  K RDR R R   + R    
Sbjct: 50  SRGRLGSQESPRSWGLGQAHKDADGDDRQRERDRVREKT-EKERDRDRKRDRERRR---- 104

Query: 488 LGSPSKERDHRRSRSPSKERQCRQSRSSSKERDHRRSRSPSKERQRRQSRSPNKERDRSQ 547
                KE++  R+R   K+ +  + R   K++   R R   +ER+R + R   KER+R  
Sbjct: 105 -----KEKETNRNRDREKQTEIERDREREKQKGRERERDRGRERERDRDRE--KERERQT 157

Query: 548 SRSPSEEREHRQSRSPSKERDRRRWRSPSKERERRQSRSSSEERDHSRSRSPNKQSGYSR 607
            +    +RE    R   +ER++++ R   ++R+R++      ER   R R   +++   R
Sbjct: 158 EKDRDGQRETETERERDREREKQKERETERDRDRQRDTEKERERQTDRERDRQRKTQTER 217

Query: 608 PRASSKEKAHSRSRTPSKEGNHSQSRTSSKESDPSQSTVPRSPDWKRSPTRTSSLSQNRT 667
            R + +E      R   ++ +  + +   +E D  +         ++   +     + R 
Sbjct: 218 QRETDREGERETDRRRERQRDRDRGKERDRERDRKEERKKERKKERKKERKEKKKEEKRR 277

Query: 668 PSK 670
             K
Sbjct: 278 EDK 280



 Score = 53.1 bits (126), Expect = 9e-07
 Identities = 38/181 (20%), Positives = 63/181 (34%), Gaps = 6/181 (3%)

Query: 261 EMSSRVKSYNQASTRSRPQSHSQSRSPRRSRSGSQKRTHSRVRSHSWKRNHSRARS--RT 318
           E   + K  N+   R +     + R   + +   ++R   R R     R   R R   + 
Sbjct: 101 ERRRKEKETNRNRDREKQTEIERDREREKQKGRERERDRGRERERDRDREKERERQTEKD 160

Query: 319 RKGILSQMGRHSQSRSHSKGKSQNQSRTPRRGRSHNWSRNPSKERSHSHSRSSSKERDHR 378
           R G         + R   K K +   R   R R     R    +R     R +  ER   
Sbjct: 161 RDGQRETETERERDREREKQKERETERDRDRQRDTEKERERQTDRERDRQRKTQTERQRE 220

Query: 379 GSSSPRKESGRSQSGSPNKQRDHSRSRSPNKARDRSRSRSPYKARDRSRSRSPNKARDCS 438
                 +E+ R +     +QRD  R +  ++ RDR   R   + ++R + R   K  +  
Sbjct: 221 TDREGERETDRRRE----RQRDRDRGKERDRERDRKEERKKERKKERKKERKEKKKEEKR 276

Query: 439 R 439
           R
Sbjct: 277 R 277



 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 45/187 (24%), Positives = 75/187 (40%), Gaps = 15/187 (8%)

Query: 485 HSQLGSPSKE----RDHRRSRSPSKERQCRQSRSSSKERDHRRSRSPSKERQRRQSRSPN 540
           HS LG+   E     D  R R  S+E      RS    + H+ +    ++R+R + R   
Sbjct: 33  HSSLGTLWVEVTIPLDFSRGRLGSQE----SPRSWGLGQAHKDADGDDRQRERDRVREKT 88

Query: 541 -KERDRSQSRSPSEEREHRQSRSPSKERDRRRWRSPSKERERRQSRSSSEERDHSRSRSP 599
            KERDR + R     R+ +++      R+R R +    ER+R + +    ER+  R R  
Sbjct: 89  EKERDRDRKRDRERRRKEKETN-----RNRDREKQTEIERDREREKQKGRERERDRGRER 143

Query: 600 NKQSGYSRPRASSKEKAHSRSRTPSKEGNHSQSRTSSKESDPSQSTVPRSPDWKRSPTRT 659
            +     + R    EK     R    E    + R   KE +  +    R  D ++   R 
Sbjct: 144 ERDRDREKERERQTEKDRDGQRETETERERDREREKQKERETERDR-DRQRDTEKERERQ 202

Query: 660 SSLSQNR 666
           +   ++R
Sbjct: 203 TDRERDR 209



 Score = 39.3 bits (90), Expect = 0.013
 Identities = 35/172 (20%), Positives = 62/172 (36%), Gaps = 9/172 (5%)

Query: 253 REKSYSPTEMSSRVKSYNQASTRSRPQSHSQSRSPRRSRSGSQK----RTHSRVRSHSWK 308
           R++     +   R +   +   R R +   + R   + R G ++    R   R R    +
Sbjct: 123 RDREREKQKGRERERDRGRERERDRDREKERERQTEKDRDGQRETETERERDREREKQKE 182

Query: 309 RNHSRARSRTRKGILSQMGRHSQSRSHS-KGKSQNQSRTPRRGRSHNWSRNPSKERSHSH 367
           R   R R R R     +  +  + R    K +++ Q  T R G      R   +ER    
Sbjct: 183 RETERDRDRQRDTEKERERQTDRERDRQRKTQTERQRETDREGERETDRR---RERQRDR 239

Query: 368 SRSSSKERDHRGSSSPRKESGRSQSGSPNKQRDHSRSRSPNKARDRSRSRSP 419
            R   ++R+ R     RK+  + +     K++     R  +K R      SP
Sbjct: 240 DRGKERDRE-RDRKEERKKERKKERKKERKEKKKEEKRREDKKRKWGEGISP 290


>gi|239747174 PREDICTED: hypothetical protein XP_002343931, partial
           [Homo sapiens]
          Length = 213

 Score =  100 bits (249), Expect = 5e-21
 Identities = 59/213 (27%), Positives = 98/213 (46%), Gaps = 7/213 (3%)

Query: 384 RKESGRSQSGSPNKQRDHSRSRSPNKARDR---SRSRSPYKARDRSRSRSPNKARDCSRS 440
           + E   + + +    R   R R  ++ RDR   S++   +  RDR R R  N+ RD  R 
Sbjct: 4   KTEGRHTHTETETMDRQRERRRETDRERDRAKESKTEDRHSERDRQRDRERNRERDRDRE 63

Query: 441 RSPYKARDRSRSRSPNKARDHSRSRSPNKARDRSRSRSPSKERDHSQLGSPSKERDHRRS 500
           R   K  DR   R   + RD  R R   + RD+ R      E D  +     +E +  R 
Sbjct: 64  RE--KQTDREGERQRERERDRDRQRETERERDKERETDRHTETDRERQKQKEREMERVRD 121

Query: 501 RSPSKERQCRQSRSSSKERDHRRSRSPSKERQR-RQSRSPNKERDRSQSRSPSEEREHRQ 559
           R   K+++  + R + +E D  R R   +ER+  R+ ++ ++ R+R + R    ER+ R+
Sbjct: 122 REREKQKEMGRERQTDRETDRERERQAERERETGRERKTEDRHRERERERKRERERK-RE 180

Query: 560 SRSPSKERDRRRWRSPSKERERRQSRSSSEERD 592
           ++   +  D  R R    +R+R + R S  ERD
Sbjct: 181 TKERERHTDMERERQRETDRKRDRQRESERERD 213



 Score = 98.6 bits (244), Expect = 2e-20
 Identities = 62/212 (29%), Positives = 98/212 (46%), Gaps = 13/212 (6%)

Query: 401 HSRSRSPNKARDRSRSRSPYKARDRSR-SRSPNKARDCSRSRSPYKARDRSRSRSPNKAR 459
           H+ + +    R R R R   + RDR++ S++ ++  +  R R   + R+R R R   K  
Sbjct: 9   HTHTETETMDRQRERRRETDRERDRAKESKTEDRHSERDRQRDRERNRERDRDREREKQT 68

Query: 460 DHSRSRSPNKARDRSRSRSPSKERDHSQLGSPSKERDHRRSRSPSKERQCRQSRSSSKER 519
           D    R   + RDR R R   +ERD        KER+  R     +ERQ ++ R   + R
Sbjct: 69  DREGERQRERERDRDRQRETERERD--------KERETDRHTETDRERQKQKEREMERVR 120

Query: 520 DHRRSRSPSKERQRRQSRSPNKERDRSQSRSPSEEREHR-QSRSPSKERDRRRWRS---P 575
           D  R +     R+R+  R  ++ER+R   R     RE + + R   +ER+R+R R     
Sbjct: 121 DREREKQKEMGRERQTDRETDRERERQAERERETGRERKTEDRHRERERERKRERERKRE 180

Query: 576 SKERERRQSRSSSEERDHSRSRSPNKQSGYSR 607
           +KERER        +R+  R R   ++S   R
Sbjct: 181 TKERERHTDMERERQRETDRKRDRQRESERER 212



 Score = 95.1 bits (235), Expect = 2e-19
 Identities = 58/213 (27%), Positives = 94/213 (44%), Gaps = 9/213 (4%)

Query: 362 ERSHSHSRSSSKERDH---RGSSSPRKESGRSQSGSPNKQRDHSRSRSPNKARDRSRSRS 418
           E  H+H+ + + +R     R +   R  +  S++   + +RD  R R  N+ RDR R R 
Sbjct: 6   EGRHTHTETETMDRQRERRRETDRERDRAKESKTEDRHSERDRQRDRERNRERDRDRERE 65

Query: 419 PYKARDRSRSRSPNKARDCSRSRSPYKARDRSRSRSPNKARDHSRSRSPNKARDRSRSRS 478
             K  DR   R   + RD  R R   + RD+ R    +   D  R +   +  +R R R 
Sbjct: 66  --KQTDREGERQRERERDRDRQRETERERDKERETDRHTETDRERQKQKEREMERVRDRE 123

Query: 479 PSKERDHSQLGSPSKERDHRRSRSPSKERQCRQSRSSSKERDHRRSRSPSKERQRRQSRS 538
             K+++  +     +E D  R R   +ER+  + R   K  D  R R   ++R+R + R 
Sbjct: 124 REKQKEMGRERQTDRETDRERERQAERERETGRER---KTEDRHRERERERKRERERKRE 180

Query: 539 PNKERDRSQSRSPSEEREHRQSRSPSKERDRRR 571
             KER+R        +RE  + R   +E +R R
Sbjct: 181 -TKERERHTDMERERQRETDRKRDRQRESERER 212



 Score = 90.5 bits (223), Expect = 5e-18
 Identities = 56/215 (26%), Positives = 92/215 (42%), Gaps = 6/215 (2%)

Query: 343 QSRTPRRGRSHNWSRNPSKERSHSHSRSSSKERDH-RGSSSPRKESGRSQSGSPNKQRDH 401
           +S+T  R   H  +   + +R     R + +ERD  + S +  + S R +     + R+ 
Sbjct: 2   ESKTEGR---HTHTETETMDRQRERRRETDRERDRAKESKTEDRHSERDRQRDRERNRER 58

Query: 402 SRSRSPNKARDRSRSRSPYKARDRSRSRSPNKARDCSRSRSPYKARDRSRSRSPNKARDH 461
            R R   K  DR   R   + RDR R R   + RD  R    +   DR R +   +  + 
Sbjct: 59  DRDREREKQTDREGERQRERERDRDRQRETERERDKERETDRHTETDRERQKQKEREMER 118

Query: 462 SRSRSPNKARDRSRSRSPSKERDHSQLGSPSKERDHRRSRSPSKERQCRQSRSSSKERDH 521
            R R   K ++  R R   +E D  +     +ER+  R R  +++R   + R   +ER+ 
Sbjct: 119 VRDREREKQKEMGRERQTDRETDRERERQAERERETGRERK-TEDRHRERERERKRERER 177

Query: 522 RRSRSPSKERQRRQSRSPNKERDRSQSRSPSEERE 556
           +R  +  +ER     R   +E DR + R    ERE
Sbjct: 178 KR-ETKERERHTDMERERQRETDRKRDRQRESERE 211



 Score = 85.1 bits (209), Expect = 2e-16
 Identities = 57/215 (26%), Positives = 94/215 (43%), Gaps = 11/215 (5%)

Query: 335 HSKGKSQNQSRTPRRGRSHNWSRNPSKERSHSHSRSSSKERDHRGSSSPRKESGRSQSGS 394
           H+  +++   R   R R  +  R+ +KE   S +     ERD +      +E  R +   
Sbjct: 9   HTHTETETMDRQRERRRETDRERDRAKE---SKTEDRHSERDRQRDRERNRERDRDRERE 65

Query: 395 PNKQRDHSRSRSPNKARDRSRSRSPYKARDRSRSRSPNKARDCSRSRSPYKARDRSRSRS 454
             KQ D    R   + RDR R R   + RD+ R    +   D  R +   +  +R R R 
Sbjct: 66  --KQTDREGERQRERERDRDRQRETERERDKERETDRHTETDRERQKQKEREMERVRDRE 123

Query: 455 PNKARDHSRSRSPNKARDRSRSRSPSKERDHSQLGSPSKERDHRRSRSPSKERQCRQSRS 514
             K ++  R R  ++  DR R R   +ER   + G   K  D  R R   ++R+ R+ + 
Sbjct: 124 REKQKEMGRERQTDRETDRERERQAERER---ETGRERKTEDRHRERERERKRE-RERKR 179

Query: 515 SSKERDHRRSRSPSKERQRRQSRSPNKERDRSQSR 549
            +KER+  R     +ERQR   R  +++R+  + R
Sbjct: 180 ETKERE--RHTDMERERQRETDRKRDRQRESERER 212



 Score = 82.0 bits (201), Expect = 2e-15
 Identities = 49/212 (23%), Positives = 90/212 (42%), Gaps = 11/212 (5%)

Query: 327 GRHSQSRSHSKGKSQNQSRTPRRGR-----SHNWSRNPSKERSHSHSRSSSKERDHRGSS 381
           GRH+ + + +  + + + R   R R     S    R+  ++R     R+  ++RD     
Sbjct: 7   GRHTHTETETMDRQRERRRETDRERDRAKESKTEDRHSERDRQRDRERNRERDRDREREK 66

Query: 382 SPRKESGRSQSGSPNKQRDHSRSRSPNKARDRSRSRSPYKARDRSRSRSPNKARDCSRSR 441
              +E  R +     ++RD  R R   + RD+ R    +   DR R +   +  +  R R
Sbjct: 67  QTDREGERQRE----RERDRDRQRETERERDKERETDRHTETDRERQKQKEREMERVRDR 122

Query: 442 SPYKARDRSRSRSPNKARDHSRSRSPNKARDRSRSRSPSKERDHSQLGSPSKERDHRRSR 501
              K ++  R R  ++  D  R R   + R+  R R  +++R   +     +ER+ +R  
Sbjct: 123 EREKQKEMGRERQTDRETDRERERQAERERETGRERK-TEDRHRERERERKRERERKRE- 180

Query: 502 SPSKERQCRQSRSSSKERDHRRSRSPSKERQR 533
           +  +ER     R   +E D +R R    ER+R
Sbjct: 181 TKERERHTDMERERQRETDRKRDRQRESERER 212



 Score = 79.3 bits (194), Expect = 1e-14
 Identities = 56/227 (24%), Positives = 92/227 (40%), Gaps = 16/227 (7%)

Query: 295 QKRTHSRVRSHSWKRNHSRARSRTRKGILSQMGRHSQSRSHSKGKSQNQSRTPRRGRSHN 354
           + +T  R  +H+      R R R R     +  R       SK + ++  R  +R R  N
Sbjct: 2   ESKTEGR-HTHTETETMDRQRERRR-----ETDRERDRAKESKTEDRHSERDRQRDRERN 55

Query: 355 WSRNPSKERSHSHSRSSSKERDHRGSSSPRKESGRSQSGSPNKQRDHSRSRSPNKARDRS 414
             R+  +ER         K+ D  G     +E  R +     ++RD  R    +   DR 
Sbjct: 56  RERDRDRERE--------KQTDREGERQRERERDRDRQRETERERDKERETDRHTETDRE 107

Query: 415 RSRSPYKARDRSRSRSPNKARDCSRSRSPYKARDRSRSRSPNKARDHSRSR-SPNKARDR 473
           R +   +  +R R R   K ++  R R   +  DR R R   + R+  R R + ++ R+R
Sbjct: 108 RQKQKEREMERVRDREREKQKEMGRERQTDRETDRERERQAERERETGRERKTEDRHRER 167

Query: 474 SRSRSPSKERDHSQLGSPSKERDHRRSRSPSKERQCRQSRSSSKERD 520
            R R   +ER   +     +  D  R R    +R+  + R S +ERD
Sbjct: 168 ERERKRERERKR-ETKERERHTDMERERQRETDRKRDRQRESERERD 213



 Score = 77.0 bits (188), Expect = 6e-14
 Identities = 48/205 (23%), Positives = 86/205 (41%), Gaps = 5/205 (2%)

Query: 494 ERDHRRSRSPSKERQCRQSRSSSKERDHRRSRSPS---KERQRRQSRSPNKERDRSQSRS 550
           E  H  + + + +RQ  + R + +ERD  +         ER R++ R  N+ERDR + R 
Sbjct: 6   EGRHTHTETETMDRQRERRRETDRERDRAKESKTEDRHSERDRQRDRERNRERDRDRERE 65

Query: 551 PSEEREHRQSRSPSKERDRRRWRSPSKERERRQSRSSSEERDHSRSRSPNKQSGYSRPRA 610
              +RE  + R   +ERDR R R   +ER++ +      E D  R +   ++    R R 
Sbjct: 66  KQTDREGERQRE--RERDRDRQRETERERDKERETDRHTETDRERQKQKEREMERVRDRE 123

Query: 611 SSKEKAHSRSRTPSKEGNHSQSRTSSKESDPSQSTVPRSPDWKRSPTRTSSLSQNRTPSK 670
             K+K   R R   +E +  + R + +E +  +         +R   R     + R   +
Sbjct: 124 REKQKEMGRERQTDRETDRERERQAERERETGRERKTEDRHRERERERKRERERKRETKE 183

Query: 671 TSSHSPSTFPSGGQTLSQDDSQADA 695
              H+        +T  + D Q ++
Sbjct: 184 RERHTDMERERQRETDRKRDRQRES 208



 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 41/174 (23%), Positives = 72/174 (41%), Gaps = 1/174 (0%)

Query: 482 ERDHSQLGSPSKERDHRRSRSPSKER-QCRQSRSSSKERDHRRSRSPSKERQRRQSRSPN 540
           E  H+   + + +R   R R   +ER + ++S++  +  +  R R   + R+R + R   
Sbjct: 6   EGRHTHTETETMDRQRERRRETDRERDRAKESKTEDRHSERDRQRDRERNRERDRDRERE 65

Query: 541 KERDRSQSRSPSEEREHRQSRSPSKERDRRRWRSPSKERERRQSRSSSEERDHSRSRSPN 600
           K+ DR   R    ER+  + R   +ERD+ R      E +R + +    E +  R R   
Sbjct: 66  KQTDREGERQRERERDRDRQRETERERDKERETDRHTETDRERQKQKEREMERVRDRERE 125

Query: 601 KQSGYSRPRASSKEKAHSRSRTPSKEGNHSQSRTSSKESDPSQSTVPRSPDWKR 654
           KQ    R R + +E    R R   +E    + R +       +    R  + KR
Sbjct: 126 KQKEMGRERQTDRETDRERERQAERERETGRERKTEDRHRERERERKRERERKR 179



 Score = 69.7 bits (169), Expect = 9e-12
 Identities = 56/235 (23%), Positives = 86/235 (36%), Gaps = 43/235 (18%)

Query: 275 RSRPQSHSQSRSPRRSRSGSQKRTHS-RVRSHSWKRNHSRARSRTRKGILSQMGRHSQSR 333
           R R +     R   R++    +  HS R R    +RN  R R R R              
Sbjct: 19  RQRERRRETDRERDRAKESKTEDRHSERDRQRDRERNRERDRDRER-------------- 64

Query: 334 SHSKGKSQNQSRTPRRGRSHNWSRNPSKERSHSHSRSSSKERDHRGSSSPRKESGRSQSG 393
                    + +T R G      R   +ER     R + +ERD    +    E+ R +  
Sbjct: 65  ---------EKQTDREG-----ERQRERERDRDRQRETERERDKERETDRHTETDRERQK 110

Query: 394 SPNKQRDHSRSRSPNKARDRSRSRSPYKARDRSRSRSPNKARDCSRSRSPYKARDRSRSR 453
              ++ +  R R   K ++  R R   +  DR R R   + R+  R R   K  DR R R
Sbjct: 111 QKEREMERVRDREREKQKEMGRERQTDRETDRERERQAERERETGRER---KTEDRHRER 167

Query: 454 SPNKARDHSRSRSPNKARDRSRSRSPSKERDHSQLGSPSKERDHRRSRSPSKERQ 508
              + R+  R R   + ++R R     +ER         +E D +R R    ER+
Sbjct: 168 ERERKRERERKR---ETKERERHTDMERER--------QRETDRKRDRQRESERE 211



 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 37/139 (26%), Positives = 65/139 (46%), Gaps = 13/139 (9%)

Query: 515 SSKERDHRRSRSPSKERQRRQSRSPNKERDR---SQSRSPSEEREHRQSRSPSKERDRRR 571
           S  E  H  + + + +RQR + R  ++ERDR   S++     ER+ ++ R  ++ERDR R
Sbjct: 3   SKTEGRHTHTETETMDRQRERRRETDRERDRAKESKTEDRHSERDRQRDRERNRERDRDR 62

Query: 572 WRSP----------SKERERRQSRSSSEERDHSRSRSPNKQSGYSRPRASSKEKAHSRSR 621
            R             +ER+R + R +  ERD  R    + ++   R +   +E    R R
Sbjct: 63  EREKQTDREGERQRERERDRDRQRETERERDKERETDRHTETDRERQKQKEREMERVRDR 122

Query: 622 TPSKEGNHSQSRTSSKESD 640
              K+    + R + +E+D
Sbjct: 123 EREKQKEMGRERQTDRETD 141



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 50/235 (21%), Positives = 81/235 (34%), Gaps = 48/235 (20%)

Query: 253 REKSYSPTEMSSRVKSYNQASTRSRPQSHSQSRSPRRSRSGSQKRTHSRVRSHSWKRNHS 312
           R ++    + +   K+ ++ S R R +   ++R   R R   ++      R    +R+  
Sbjct: 24  RRETDRERDRAKESKTEDRHSERDRQRDRERNRERDRDREREKQTDREGERQRERERDRD 83

Query: 313 RARSRTRKGILSQMGRHSQSRSHSKGKSQNQSRTPRRGRSHNWSRNPSKERSHSHSRSSS 372
           R R   R+                    +++ R   R    +  R   KER     R   
Sbjct: 84  RQRETERE--------------------RDKERETDRHTETDRERQKQKEREMERVRDRE 123

Query: 373 KERDHRGSSSPRKESGRSQSGSPNKQRDHSRSRSPNKARDRSRSRSPYKARDRSRSRSPN 432
           +E                      KQ++  R R  ++  DR R R   + R+  R R   
Sbjct: 124 RE----------------------KQKEMGRERQTDRETDRERERQAERERETGRER--- 158

Query: 433 KARDCSRSRSPYKARDRSRSRSPNKARDHS---RSRSPNKARDRSRSRSPSKERD 484
           K  D  R R   + R+R R R   +   H+   R R     R R R R   +ERD
Sbjct: 159 KTEDRHRERERERKRERERKRETKERERHTDMERERQRETDRKRDRQRESERERD 213


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.302    0.113    0.310 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 30,781,741
Number of Sequences: 37866
Number of extensions: 1734599
Number of successful extensions: 52838
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 644
Number of HSP's successfully gapped in prelim test: 1432
Number of HSP's that attempted gapping in prelim test: 11458
Number of HSP's gapped (non-prelim): 13121
length of query: 715
length of database: 18,247,518
effective HSP length: 109
effective length of query: 606
effective length of database: 14,120,124
effective search space: 8556795144
effective search space used: 8556795144
T: 11
A: 40
X1: 17 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (21.9 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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