Search of human proteins with 223718250

Search of human proteins with 223718250

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|223718250 plastin 1 [Homo sapiens]
         (629 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|223718250 plastin 1 [Homo sapiens]                                1246   0.0  
gi|223718246 plastin 1 [Homo sapiens]                                1246   0.0  
gi|209862851 plastin 3 [Homo sapiens]                                 984   0.0  
gi|7549809 plastin 3 [Homo sapiens]                                   984   0.0  
gi|167614506 L-plastin [Homo sapiens]                                 962   0.0  
gi|221316624 dystonin isoform 4 [Homo sapiens]                         71   3e-12
gi|221316622 dystonin isoform 3 [Homo sapiens]                         71   3e-12
gi|221316618 dystonin isoform 2 [Homo sapiens]                         71   3e-12
gi|34577047 dystonin isoform 1 [Homo sapiens]                          71   3e-12
gi|41322923 plectin 1 isoform 11 [Homo sapiens]                        69   1e-11
gi|41322912 plectin 1 isoform 2 [Homo sapiens]                         66   8e-11
gi|41322919 plectin 1 isoform 8 [Homo sapiens]                         65   1e-10
gi|41322914 plectin 1 isoform 10 [Homo sapiens]                        65   2e-10
gi|41322910 plectin 1 isoform 7 [Homo sapiens]                         65   2e-10
gi|41322916 plectin 1 isoform 6 [Homo sapiens]                         65   2e-10
gi|41322908 plectin 1 isoform 3 [Homo sapiens]                         65   2e-10
gi|47607492 plectin 1 isoform 1 [Homo sapiens]                         65   2e-10
gi|169218211 PREDICTED: similar to plectin 1, partial [Homo sapi...    62   2e-09
gi|33188445 microfilament and actin filament cross-linker protei...    61   3e-09
gi|160420317 filamin A, alpha isoform 2 [Homo sapiens]                 61   4e-09
gi|116063573 filamin A, alpha isoform 1 [Homo sapiens]                 61   4e-09
gi|67782321 spectrin beta isoform a [Homo sapiens]                     61   4e-09
gi|67782319 spectrin beta isoform b [Homo sapiens]                     61   4e-09
gi|154277116 spectrin repeat containing, nuclear envelope 1 isof...    60   6e-09
gi|12025678 actinin, alpha 4 [Homo sapiens]                            57   5e-08
gi|188595687 gamma filamin isoform b [Homo sapiens]                    55   2e-07
gi|116805322 gamma filamin isoform a [Homo sapiens]                    55   2e-07
gi|115430237 spectrin, beta, non-erythrocytic 4 isoform sigma1 [...    54   3e-07
gi|5032281 dystrophin Dp427c isoform [Homo sapiens]                    54   4e-07
gi|5032287 dystrophin Dp427p1 isoform [Homo sapiens]                   54   4e-07

>gi|223718250 plastin 1 [Homo sapiens]
          Length = 629

 Score = 1246 bits (3223), Expect = 0.0
 Identities = 629/629 (100%), Positives = 629/629 (100%)

Query: 1   MENSTTTISREELEELQEAFNKIDIDNSGYVSDYELQDLFKEASLPLPGYKVREIVEKIL 60
           MENSTTTISREELEELQEAFNKIDIDNSGYVSDYELQDLFKEASLPLPGYKVREIVEKIL
Sbjct: 1   MENSTTTISREELEELQEAFNKIDIDNSGYVSDYELQDLFKEASLPLPGYKVREIVEKIL 60

Query: 61  SVADSNKDGKISFEEFVSLMQELKSKDISKTFRKIINKREGITAIGGTSTISSEGTQHSY 120
           SVADSNKDGKISFEEFVSLMQELKSKDISKTFRKIINKREGITAIGGTSTISSEGTQHSY
Sbjct: 61  SVADSNKDGKISFEEFVSLMQELKSKDISKTFRKIINKREGITAIGGTSTISSEGTQHSY 120

Query: 121 SEEEKVAFVNWINKALENDPDCKHLIPMNPNDDSLFKSLADGILLCKMINLSEPDTIDER 180
           SEEEKVAFVNWINKALENDPDCKHLIPMNPNDDSLFKSLADGILLCKMINLSEPDTIDER
Sbjct: 121 SEEEKVAFVNWINKALENDPDCKHLIPMNPNDDSLFKSLADGILLCKMINLSEPDTIDER 180

Query: 181 AINKKKLTPFTISENLNLALNSASAIGCTVVNIGASDLKEGKPHLVLGLLWQIIKVGLFA 240
           AINKKKLTPFTISENLNLALNSASAIGCTVVNIGASDLKEGKPHLVLGLLWQIIKVGLFA
Sbjct: 181 AINKKKLTPFTISENLNLALNSASAIGCTVVNIGASDLKEGKPHLVLGLLWQIIKVGLFA 240

Query: 241 DIEISRNEALIALLNEGEELEELMKLSPEELLLRWVNYHLTNAGWHTISNFSQDIKDSRA 300
           DIEISRNEALIALLNEGEELEELMKLSPEELLLRWVNYHLTNAGWHTISNFSQDIKDSRA
Sbjct: 241 DIEISRNEALIALLNEGEELEELMKLSPEELLLRWVNYHLTNAGWHTISNFSQDIKDSRA 300

Query: 301 YFHLLNQIAPKGGEDGPAIAIDLSGINETNDLKRAGLMLQEADKLGCKQFVTPADVVSGN 360
           YFHLLNQIAPKGGEDGPAIAIDLSGINETNDLKRAGLMLQEADKLGCKQFVTPADVVSGN
Sbjct: 301 YFHLLNQIAPKGGEDGPAIAIDLSGINETNDLKRAGLMLQEADKLGCKQFVTPADVVSGN 360

Query: 361 PKLNLAFVANLFNTYPCLHKPNNNDIDMNLLEGESKEERTFRNWMNSLGVNPYINHLYSD 420
           PKLNLAFVANLFNTYPCLHKPNNNDIDMNLLEGESKEERTFRNWMNSLGVNPYINHLYSD
Sbjct: 361 PKLNLAFVANLFNTYPCLHKPNNNDIDMNLLEGESKEERTFRNWMNSLGVNPYINHLYSD 420

Query: 421 LADALVIFQLYEMIRVPVNWSHVNKPPYPALGGNMKKIENCNYAVELGKNKAKFSLVGIA 480
           LADALVIFQLYEMIRVPVNWSHVNKPPYPALGGNMKKIENCNYAVELGKNKAKFSLVGIA
Sbjct: 421 LADALVIFQLYEMIRVPVNWSHVNKPPYPALGGNMKKIENCNYAVELGKNKAKFSLVGIA 480

Query: 481 GQDLNEGNSTLTLALVWQLMRRYTLNVLSDLGEGEKVNDEIIIKWVNQTLKSANKKTSIS 540
           GQDLNEGNSTLTLALVWQLMRRYTLNVLSDLGEGEKVNDEIIIKWVNQTLKSANKKTSIS
Sbjct: 481 GQDLNEGNSTLTLALVWQLMRRYTLNVLSDLGEGEKVNDEIIIKWVNQTLKSANKKTSIS 540

Query: 541 SFKDKSISTSLPVLDLIDAIAPNAVRQEMIRRENLSDEDKLNNAKYAISVARKIGARIYA 600
           SFKDKSISTSLPVLDLIDAIAPNAVRQEMIRRENLSDEDKLNNAKYAISVARKIGARIYA
Sbjct: 541 SFKDKSISTSLPVLDLIDAIAPNAVRQEMIRRENLSDEDKLNNAKYAISVARKIGARIYA 600

Query: 601 LPDDLVEVKPKMVMTVFACLMGKGLNRIK 629
           LPDDLVEVKPKMVMTVFACLMGKGLNRIK
Sbjct: 601 LPDDLVEVKPKMVMTVFACLMGKGLNRIK 629


>gi|223718246 plastin 1 [Homo sapiens]
          Length = 629

 Score = 1246 bits (3223), Expect = 0.0
 Identities = 629/629 (100%), Positives = 629/629 (100%)

Query: 1   MENSTTTISREELEELQEAFNKIDIDNSGYVSDYELQDLFKEASLPLPGYKVREIVEKIL 60
           MENSTTTISREELEELQEAFNKIDIDNSGYVSDYELQDLFKEASLPLPGYKVREIVEKIL
Sbjct: 1   MENSTTTISREELEELQEAFNKIDIDNSGYVSDYELQDLFKEASLPLPGYKVREIVEKIL 60

Query: 61  SVADSNKDGKISFEEFVSLMQELKSKDISKTFRKIINKREGITAIGGTSTISSEGTQHSY 120
           SVADSNKDGKISFEEFVSLMQELKSKDISKTFRKIINKREGITAIGGTSTISSEGTQHSY
Sbjct: 61  SVADSNKDGKISFEEFVSLMQELKSKDISKTFRKIINKREGITAIGGTSTISSEGTQHSY 120

Query: 121 SEEEKVAFVNWINKALENDPDCKHLIPMNPNDDSLFKSLADGILLCKMINLSEPDTIDER 180
           SEEEKVAFVNWINKALENDPDCKHLIPMNPNDDSLFKSLADGILLCKMINLSEPDTIDER
Sbjct: 121 SEEEKVAFVNWINKALENDPDCKHLIPMNPNDDSLFKSLADGILLCKMINLSEPDTIDER 180

Query: 181 AINKKKLTPFTISENLNLALNSASAIGCTVVNIGASDLKEGKPHLVLGLLWQIIKVGLFA 240
           AINKKKLTPFTISENLNLALNSASAIGCTVVNIGASDLKEGKPHLVLGLLWQIIKVGLFA
Sbjct: 181 AINKKKLTPFTISENLNLALNSASAIGCTVVNIGASDLKEGKPHLVLGLLWQIIKVGLFA 240

Query: 241 DIEISRNEALIALLNEGEELEELMKLSPEELLLRWVNYHLTNAGWHTISNFSQDIKDSRA 300
           DIEISRNEALIALLNEGEELEELMKLSPEELLLRWVNYHLTNAGWHTISNFSQDIKDSRA
Sbjct: 241 DIEISRNEALIALLNEGEELEELMKLSPEELLLRWVNYHLTNAGWHTISNFSQDIKDSRA 300

Query: 301 YFHLLNQIAPKGGEDGPAIAIDLSGINETNDLKRAGLMLQEADKLGCKQFVTPADVVSGN 360
           YFHLLNQIAPKGGEDGPAIAIDLSGINETNDLKRAGLMLQEADKLGCKQFVTPADVVSGN
Sbjct: 301 YFHLLNQIAPKGGEDGPAIAIDLSGINETNDLKRAGLMLQEADKLGCKQFVTPADVVSGN 360

Query: 361 PKLNLAFVANLFNTYPCLHKPNNNDIDMNLLEGESKEERTFRNWMNSLGVNPYINHLYSD 420
           PKLNLAFVANLFNTYPCLHKPNNNDIDMNLLEGESKEERTFRNWMNSLGVNPYINHLYSD
Sbjct: 361 PKLNLAFVANLFNTYPCLHKPNNNDIDMNLLEGESKEERTFRNWMNSLGVNPYINHLYSD 420

Query: 421 LADALVIFQLYEMIRVPVNWSHVNKPPYPALGGNMKKIENCNYAVELGKNKAKFSLVGIA 480
           LADALVIFQLYEMIRVPVNWSHVNKPPYPALGGNMKKIENCNYAVELGKNKAKFSLVGIA
Sbjct: 421 LADALVIFQLYEMIRVPVNWSHVNKPPYPALGGNMKKIENCNYAVELGKNKAKFSLVGIA 480

Query: 481 GQDLNEGNSTLTLALVWQLMRRYTLNVLSDLGEGEKVNDEIIIKWVNQTLKSANKKTSIS 540
           GQDLNEGNSTLTLALVWQLMRRYTLNVLSDLGEGEKVNDEIIIKWVNQTLKSANKKTSIS
Sbjct: 481 GQDLNEGNSTLTLALVWQLMRRYTLNVLSDLGEGEKVNDEIIIKWVNQTLKSANKKTSIS 540

Query: 541 SFKDKSISTSLPVLDLIDAIAPNAVRQEMIRRENLSDEDKLNNAKYAISVARKIGARIYA 600
           SFKDKSISTSLPVLDLIDAIAPNAVRQEMIRRENLSDEDKLNNAKYAISVARKIGARIYA
Sbjct: 541 SFKDKSISTSLPVLDLIDAIAPNAVRQEMIRRENLSDEDKLNNAKYAISVARKIGARIYA 600

Query: 601 LPDDLVEVKPKMVMTVFACLMGKGLNRIK 629
           LPDDLVEVKPKMVMTVFACLMGKGLNRIK
Sbjct: 601 LPDDLVEVKPKMVMTVFACLMGKGLNRIK 629


>gi|209862851 plastin 3 [Homo sapiens]
          Length = 630

 Score =  984 bits (2545), Expect = 0.0
 Identities = 473/628 (75%), Positives = 554/628 (88%), Gaps = 1/628 (0%)

Query: 2   ENSTTTISREELEELQEAFNKIDIDNSGYVSDYELQDLFKEASLPLPGYKVREIVEKILS 61
           E +TT IS++EL+EL+EAF K+D++++G++ DYEL +LFKEA++PLPGYKVREI++K++ 
Sbjct: 3   EMATTQISKDELDELKEAFAKVDLNSNGFICDYELHELFKEANMPLPGYKVREIIQKLML 62

Query: 62  VADSNKDGKISFEEFVSLMQELKSKDISKTFRKIINKREGITAIGGTSTISSEGTQHSYS 121
             D NKDGKISF+EFV + QE+KS DI+KTFRK IN++EGI A+GGTS +SSEGTQHSYS
Sbjct: 63  DGDRNKDGKISFDEFVYIFQEVKSSDIAKTFRKAINRKEGICALGGTSELSSEGTQHSYS 122

Query: 122 EEEKVAFVNWINKALENDPDCKHLIPMNPNDDSLFKSLADGILLCKMINLSEPDTIDERA 181
           EEEK AFVNWINKALENDPDC+H+IPMNPN D LFK++ DGI+LCKMINLS PDTIDERA
Sbjct: 123 EEEKYAFVNWINKALENDPDCRHVIPMNPNTDDLFKAVGDGIVLCKMINLSVPDTIDERA 182

Query: 182 INKKKLTPFTISENLNLALNSASAIGCTVVNIGASDLKEGKPHLVLGLLWQIIKVGLFAD 241
           INKKKLTPF I ENLNLALNSASAIGC VVNIGA DL+ GKPHLVLGLLWQIIK+GLFAD
Sbjct: 183 INKKKLTPFIIQENLNLALNSASAIGCHVVNIGAEDLRAGKPHLVLGLLWQIIKIGLFAD 242

Query: 242 IEISRNEALIALLNEGEELEELMKLSPEELLLRWVNYHLTNAGWHTISNFSQDIKDSRAY 301
           IE+SRNEAL ALL +GE LEELMKLSPEELLLRW N+HL N+GW  I+NFS DIKDS+AY
Sbjct: 243 IELSRNEALAALLRDGETLEELMKLSPEELLLRWANFHLENSGWQKINNFSADIKDSKAY 302

Query: 302 FHLLNQIAPKGGEDG-PAIAIDLSGINETNDLKRAGLMLQEADKLGCKQFVTPADVVSGN 360
           FHLLNQIAPKG ++G P I I++SG NET+DLKRA  MLQ+ADKLGC+QFVTPADVVSGN
Sbjct: 303 FHLLNQIAPKGQKEGEPRIDINMSGFNETDDLKRAESMLQQADKLGCRQFVTPADVVSGN 362

Query: 361 PKLNLAFVANLFNTYPCLHKPNNNDIDMNLLEGESKEERTFRNWMNSLGVNPYINHLYSD 420
           PKLNLAFVANLFN YP L KP N DID  LLEGE++EERTFRNWMNSLGVNP++NHLY+D
Sbjct: 363 PKLNLAFVANLFNKYPALTKPENQDIDWTLLEGETREERTFRNWMNSLGVNPHVNHLYAD 422

Query: 421 LADALVIFQLYEMIRVPVNWSHVNKPPYPALGGNMKKIENCNYAVELGKNKAKFSLVGIA 480
           L DALVI QLYE I+VPV+WS VNKPPYP LG NMKK+ENCNYAVELGK+ AKFSLVGI 
Sbjct: 423 LQDALVILQLYERIKVPVDWSKVNKPPYPKLGANMKKLENCNYAVELGKHPAKFSLVGIG 482

Query: 481 GQDLNEGNSTLTLALVWQLMRRYTLNVLSDLGEGEKVNDEIIIKWVNQTLKSANKKTSIS 540
           GQDLN+GN TLTLALVWQLMRRYTLNVL DLG+G+K ND+II+ WVN+TL  A K TSI 
Sbjct: 483 GQDLNDGNQTLTLALVWQLMRRYTLNVLEDLGDGQKANDDIIVNWVNRTLSEAGKSTSIQ 542

Query: 541 SFKDKSISTSLPVLDLIDAIAPNAVRQEMIRRENLSDEDKLNNAKYAISVARKIGARIYA 600
           SFKDK+IS+SL V+DLIDAI P  +  ++++  NL+++DK NNAKYA+S+AR+IGAR+YA
Sbjct: 543 SFKDKTISSSLAVVDLIDAIQPGCINYDLVKSGNLTEDDKHNNAKYAVSMARRIGARVYA 602

Query: 601 LPDDLVEVKPKMVMTVFACLMGKGLNRI 628
           LP+DLVEVKPKMVMTVFACLMG+G+ R+
Sbjct: 603 LPEDLVEVKPKMVMTVFACLMGRGMKRV 630


>gi|7549809 plastin 3 [Homo sapiens]
          Length = 630

 Score =  984 bits (2545), Expect = 0.0
 Identities = 473/628 (75%), Positives = 554/628 (88%), Gaps = 1/628 (0%)

Query: 2   ENSTTTISREELEELQEAFNKIDIDNSGYVSDYELQDLFKEASLPLPGYKVREIVEKILS 61
           E +TT IS++EL+EL+EAF K+D++++G++ DYEL +LFKEA++PLPGYKVREI++K++ 
Sbjct: 3   EMATTQISKDELDELKEAFAKVDLNSNGFICDYELHELFKEANMPLPGYKVREIIQKLML 62

Query: 62  VADSNKDGKISFEEFVSLMQELKSKDISKTFRKIINKREGITAIGGTSTISSEGTQHSYS 121
             D NKDGKISF+EFV + QE+KS DI+KTFRK IN++EGI A+GGTS +SSEGTQHSYS
Sbjct: 63  DGDRNKDGKISFDEFVYIFQEVKSSDIAKTFRKAINRKEGICALGGTSELSSEGTQHSYS 122

Query: 122 EEEKVAFVNWINKALENDPDCKHLIPMNPNDDSLFKSLADGILLCKMINLSEPDTIDERA 181
           EEEK AFVNWINKALENDPDC+H+IPMNPN D LFK++ DGI+LCKMINLS PDTIDERA
Sbjct: 123 EEEKYAFVNWINKALENDPDCRHVIPMNPNTDDLFKAVGDGIVLCKMINLSVPDTIDERA 182

Query: 182 INKKKLTPFTISENLNLALNSASAIGCTVVNIGASDLKEGKPHLVLGLLWQIIKVGLFAD 241
           INKKKLTPF I ENLNLALNSASAIGC VVNIGA DL+ GKPHLVLGLLWQIIK+GLFAD
Sbjct: 183 INKKKLTPFIIQENLNLALNSASAIGCHVVNIGAEDLRAGKPHLVLGLLWQIIKIGLFAD 242

Query: 242 IEISRNEALIALLNEGEELEELMKLSPEELLLRWVNYHLTNAGWHTISNFSQDIKDSRAY 301
           IE+SRNEAL ALL +GE LEELMKLSPEELLLRW N+HL N+GW  I+NFS DIKDS+AY
Sbjct: 243 IELSRNEALAALLRDGETLEELMKLSPEELLLRWANFHLENSGWQKINNFSADIKDSKAY 302

Query: 302 FHLLNQIAPKGGEDG-PAIAIDLSGINETNDLKRAGLMLQEADKLGCKQFVTPADVVSGN 360
           FHLLNQIAPKG ++G P I I++SG NET+DLKRA  MLQ+ADKLGC+QFVTPADVVSGN
Sbjct: 303 FHLLNQIAPKGQKEGEPRIDINMSGFNETDDLKRAESMLQQADKLGCRQFVTPADVVSGN 362

Query: 361 PKLNLAFVANLFNTYPCLHKPNNNDIDMNLLEGESKEERTFRNWMNSLGVNPYINHLYSD 420
           PKLNLAFVANLFN YP L KP N DID  LLEGE++EERTFRNWMNSLGVNP++NHLY+D
Sbjct: 363 PKLNLAFVANLFNKYPALTKPENQDIDWTLLEGETREERTFRNWMNSLGVNPHVNHLYAD 422

Query: 421 LADALVIFQLYEMIRVPVNWSHVNKPPYPALGGNMKKIENCNYAVELGKNKAKFSLVGIA 480
           L DALVI QLYE I+VPV+WS VNKPPYP LG NMKK+ENCNYAVELGK+ AKFSLVGI 
Sbjct: 423 LQDALVILQLYERIKVPVDWSKVNKPPYPKLGANMKKLENCNYAVELGKHPAKFSLVGIG 482

Query: 481 GQDLNEGNSTLTLALVWQLMRRYTLNVLSDLGEGEKVNDEIIIKWVNQTLKSANKKTSIS 540
           GQDLN+GN TLTLALVWQLMRRYTLNVL DLG+G+K ND+II+ WVN+TL  A K TSI 
Sbjct: 483 GQDLNDGNQTLTLALVWQLMRRYTLNVLEDLGDGQKANDDIIVNWVNRTLSEAGKSTSIQ 542

Query: 541 SFKDKSISTSLPVLDLIDAIAPNAVRQEMIRRENLSDEDKLNNAKYAISVARKIGARIYA 600
           SFKDK+IS+SL V+DLIDAI P  +  ++++  NL+++DK NNAKYA+S+AR+IGAR+YA
Sbjct: 543 SFKDKTISSSLAVVDLIDAIQPGCINYDLVKSGNLTEDDKHNNAKYAVSMARRIGARVYA 602

Query: 601 LPDDLVEVKPKMVMTVFACLMGKGLNRI 628
           LP+DLVEVKPKMVMTVFACLMG+G+ R+
Sbjct: 603 LPEDLVEVKPKMVMTVFACLMGRGMKRV 630


>gi|167614506 L-plastin [Homo sapiens]
          Length = 627

 Score =  962 bits (2487), Expect = 0.0
 Identities = 461/623 (73%), Positives = 541/623 (86%), Gaps = 1/623 (0%)

Query: 7   TISREELEELQEAFNKIDIDNSGYVSDYELQDLFKEASLPLPGYKVREIVEKILSVADSN 66
           ++S EE+ EL+EAF K+D D +GY+S  EL DLFK A LPLPGY+VREI E +++  D +
Sbjct: 5   SVSDEEMMELREAFAKVDTDGNGYISFNELNDLFKAACLPLPGYRVREITENLMATGDLD 64

Query: 67  KDGKISFEEFVSLMQELKSKDISKTFRKIINKREGITAIGGTSTISSEGTQHSYSEEEKV 126
           +DG+ISF+EF+ +   LKS D++KTFRK INK+EGI AIGGTS  SS GTQHSYSEEEK 
Sbjct: 65  QDGRISFDEFIKIFHGLKSTDVAKTFRKAINKKEGICAIGGTSEQSSVGTQHSYSEEEKY 124

Query: 127 AFVNWINKALENDPDCKHLIPMNPNDDSLFKSLADGILLCKMINLSEPDTIDERAINKKK 186
           AFVNWINKALENDPDC+H+IPMNPN + LF ++ DGI+LCKMINLS PDTIDER INKKK
Sbjct: 125 AFVNWINKALENDPDCRHVIPMNPNTNDLFNAVGDGIVLCKMINLSVPDTIDERTINKKK 184

Query: 187 LTPFTISENLNLALNSASAIGCTVVNIGASDLKEGKPHLVLGLLWQIIKVGLFADIEISR 246
           LTPFTI ENLNLALNSASAIGC VVNIGA DLKEGKP+LVLGLLWQ+IK+GLFADIE+SR
Sbjct: 185 LTPFTIQENLNLALNSASAIGCHVVNIGAEDLKEGKPYLVLGLLWQVIKIGLFADIELSR 244

Query: 247 NEALIALLNEGEELEELMKLSPEELLLRWVNYHLTNAGWHTISNFSQDIKDSRAYFHLLN 306
           NEALIALL EGE LE+LMKLSPEELLLRW NYHL NAG + I NFS DIKDS+AY+HLL 
Sbjct: 245 NEALIALLREGESLEDLMKLSPEELLLRWANYHLENAGCNKIGNFSTDIKDSKAYYHLLE 304

Query: 307 QIAPKGGEDG-PAIAIDLSGINETNDLKRAGLMLQEADKLGCKQFVTPADVVSGNPKLNL 365
           Q+APKG E+G PA+ ID+SG+ E +D++RA  MLQ+A++LGC+QFVT  DVV GNPKLNL
Sbjct: 305 QVAPKGDEEGVPAVVIDMSGLREKDDIQRAECMLQQAERLGCRQFVTATDVVRGNPKLNL 364

Query: 366 AFVANLFNTYPCLHKPNNNDIDMNLLEGESKEERTFRNWMNSLGVNPYINHLYSDLADAL 425
           AF+ANLFN YP LHKP N DID   LEGE++EERTFRNWMNSLGVNP +NHLYSDL+DAL
Sbjct: 365 AFIANLFNRYPALHKPENQDIDWGALEGETREERTFRNWMNSLGVNPRVNHLYSDLSDAL 424

Query: 426 VIFQLYEMIRVPVNWSHVNKPPYPALGGNMKKIENCNYAVELGKNKAKFSLVGIAGQDLN 485
           VIFQLYE I+VPV+W+ VNKPPYP LGGNMKK+ENCNYAVELGKN+AKFSLVGI GQDLN
Sbjct: 425 VIFQLYEKIKVPVDWNRVNKPPYPKLGGNMKKLENCNYAVELGKNQAKFSLVGIGGQDLN 484

Query: 486 EGNSTLTLALVWQLMRRYTLNVLSDLGEGEKVNDEIIIKWVNQTLKSANKKTSISSFKDK 545
           EGN TLTLAL+WQLMRRYTLN+L ++G G+KVND+II+ WVN+TL+ A K +SISSFKD 
Sbjct: 485 EGNRTLTLALIWQLMRRYTLNILEEIGGGQKVNDDIIVNWVNETLREAKKSSSISSFKDP 544

Query: 546 SISTSLPVLDLIDAIAPNAVRQEMIRRENLSDEDKLNNAKYAISVARKIGARIYALPDDL 605
            ISTSLPVLDLIDAI P ++  ++++ ENL+D++KLNNAKYAIS+ARKIGAR+YALP+DL
Sbjct: 545 KISTSLPVLDLIDAIQPGSINYDLLKTENLNDDEKLNNAKYAISMARKIGARVYALPEDL 604

Query: 606 VEVKPKMVMTVFACLMGKGLNRI 628
           VEV PKMVMTVFACLMGKG+ R+
Sbjct: 605 VEVNPKMVMTVFACLMGKGMKRV 627


>gi|221316624 dystonin isoform 4 [Homo sapiens]
          Length = 5526

 Score = 70.9 bits (172), Expect = 3e-12
 Identities = 62/275 (22%), Positives = 120/275 (43%), Gaps = 42/275 (15%)

Query: 124 EKVAFVNWINKALENDPDCKHLIPMNPNDDSLFKSLADGILLCKMINLSEPDTIDERAIN 183
           +K  F  WIN+         HL+ +  + + L++ L DG  L  ++ +   DT+      
Sbjct: 66  QKKTFTKWINQ---------HLMKVRKHVNDLYEDLRDGHNLISLLEVLSGDTLPR---- 112

Query: 184 KKKLTPFTISENLNLALNSASAIGCTVVNIGASDLKEGKPHLVLGLLWQIIKVGLFADIE 243
           +K    F   +N+ +AL+        +VNI   D+ +G P L LGL+W II     +DI 
Sbjct: 113 EKGRMRFHRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIH 172

Query: 244 ISRNEALIALLNEGEELEELMKLSPEELLLRWVNYHLTNAGWHTISNFSQDIKDSRAYFH 303
           ++          E E+      +S +E LL W              NF+   +D + +  
Sbjct: 173 VT---------GESED------MSAKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNA 217

Query: 304 LLNQIAPKGGEDGPAIAIDLSGINETNDLKRAGLMLQEADKLGCKQFVTPADVVSGNP-- 361
           ++++  P          ID++ +   ++L         A+K+G  + + P DV   +P  
Sbjct: 218 IIHKYRPD--------LIDMNTVAVQSNLANLEHAFYVAEKIGVIRLLDPEDVDVSSPDE 269

Query: 362 KLNLAFVANLFNTYPCLHKPNN----NDIDMNLLE 392
           K  + +V++L++ +P + +       ND+++  +E
Sbjct: 270 KSVITYVSSLYDAFPKVPEGGEGIGANDVEVKWIE 304



 Score = 68.6 bits (166), Expect = 2e-11
 Identities = 58/236 (24%), Positives = 110/236 (46%), Gaps = 24/236 (10%)

Query: 392 EGESKEERTFRNWMNS--LGVNPYINHLYSDLADALVIFQLYEMIRVPVNWSHVNKPPYP 449
           E +  +++TF  W+N   + V  ++N LY DL D   +  L E++         +    P
Sbjct: 61  ERDKVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEVL---------SGDTLP 111

Query: 450 ALGGNMK--KIENCNYAVELGKNKAKFSLVGIAGQDLNEGNSTLTLALVWQLMRRYTLNV 507
              G M+  +++N   A++  K + +  LV I   D+ +GN  LTL L+W ++  + ++ 
Sbjct: 112 REKGRMRFHRLQNVQIALDYLKRR-QVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISD 170

Query: 508 LSDLGEGEKVN-DEIIIKWVNQTLKSANKKTSISSFKDKSISTSLPVLDLIDAIAPNAVR 566
           +   GE E ++  E ++ W  Q  +        +  + ++ +T      L +AI  +  R
Sbjct: 171 IHVTGESEDMSAKERLLLWTQQATE------GYAGIRCENFTTCWRDGKLFNAII-HKYR 223

Query: 567 QEMIRRENLSDEDKLNNAKYAISVARKIGARIYALPDDLVEVKP--KMVMTVFACL 620
            ++I    ++ +  L N ++A  VA KIG      P+D+    P  K V+T  + L
Sbjct: 224 PDLIDMNTVAVQSNLANLEHAFYVAEKIGVIRLLDPEDVDVSSPDEKSVITYVSSL 279


>gi|221316622 dystonin isoform 3 [Homo sapiens]
          Length = 5537

 Score = 70.9 bits (172), Expect = 3e-12
 Identities = 62/275 (22%), Positives = 120/275 (43%), Gaps = 42/275 (15%)

Query: 124 EKVAFVNWINKALENDPDCKHLIPMNPNDDSLFKSLADGILLCKMINLSEPDTIDERAIN 183
           +K  F  WIN+         HL+ +  + + L++ L DG  L  ++ +   DT+      
Sbjct: 77  QKKTFTKWINQ---------HLMKVRKHVNDLYEDLRDGHNLISLLEVLSGDTLPR---- 123

Query: 184 KKKLTPFTISENLNLALNSASAIGCTVVNIGASDLKEGKPHLVLGLLWQIIKVGLFADIE 243
           +K    F   +N+ +AL+        +VNI   D+ +G P L LGL+W II     +DI 
Sbjct: 124 EKGRMRFHRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIH 183

Query: 244 ISRNEALIALLNEGEELEELMKLSPEELLLRWVNYHLTNAGWHTISNFSQDIKDSRAYFH 303
           ++          E E+      +S +E LL W              NF+   +D + +  
Sbjct: 184 VT---------GESED------MSAKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNA 228

Query: 304 LLNQIAPKGGEDGPAIAIDLSGINETNDLKRAGLMLQEADKLGCKQFVTPADVVSGNP-- 361
           ++++  P          ID++ +   ++L         A+K+G  + + P DV   +P  
Sbjct: 229 IIHKYRPD--------LIDMNTVAVQSNLANLEHAFYVAEKIGVIRLLDPEDVDVSSPDE 280

Query: 362 KLNLAFVANLFNTYPCLHKPNN----NDIDMNLLE 392
           K  + +V++L++ +P + +       ND+++  +E
Sbjct: 281 KSVITYVSSLYDAFPKVPEGGEGIGANDVEVKWIE 315



 Score = 68.6 bits (166), Expect = 2e-11
 Identities = 58/236 (24%), Positives = 110/236 (46%), Gaps = 24/236 (10%)

Query: 392 EGESKEERTFRNWMNS--LGVNPYINHLYSDLADALVIFQLYEMIRVPVNWSHVNKPPYP 449
           E +  +++TF  W+N   + V  ++N LY DL D   +  L E++         +    P
Sbjct: 72  ERDKVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEVL---------SGDTLP 122

Query: 450 ALGGNMK--KIENCNYAVELGKNKAKFSLVGIAGQDLNEGNSTLTLALVWQLMRRYTLNV 507
              G M+  +++N   A++  K + +  LV I   D+ +GN  LTL L+W ++  + ++ 
Sbjct: 123 REKGRMRFHRLQNVQIALDYLKRR-QVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISD 181

Query: 508 LSDLGEGEKVN-DEIIIKWVNQTLKSANKKTSISSFKDKSISTSLPVLDLIDAIAPNAVR 566
           +   GE E ++  E ++ W  Q  +        +  + ++ +T      L +AI  +  R
Sbjct: 182 IHVTGESEDMSAKERLLLWTQQATE------GYAGIRCENFTTCWRDGKLFNAII-HKYR 234

Query: 567 QEMIRRENLSDEDKLNNAKYAISVARKIGARIYALPDDLVEVKP--KMVMTVFACL 620
            ++I    ++ +  L N ++A  VA KIG      P+D+    P  K V+T  + L
Sbjct: 235 PDLIDMNTVAVQSNLANLEHAFYVAEKIGVIRLLDPEDVDVSSPDEKSVITYVSSL 290


>gi|221316618 dystonin isoform 2 [Homo sapiens]
          Length = 5675

 Score = 70.9 bits (172), Expect = 3e-12
 Identities = 62/275 (22%), Positives = 120/275 (43%), Gaps = 42/275 (15%)

Query: 124 EKVAFVNWINKALENDPDCKHLIPMNPNDDSLFKSLADGILLCKMINLSEPDTIDERAIN 183
           +K  F  WIN+         HL+ +  + + L++ L DG  L  ++ +   DT+      
Sbjct: 215 QKKTFTKWINQ---------HLMKVRKHVNDLYEDLRDGHNLISLLEVLSGDTLPR---- 261

Query: 184 KKKLTPFTISENLNLALNSASAIGCTVVNIGASDLKEGKPHLVLGLLWQIIKVGLFADIE 243
           +K    F   +N+ +AL+        +VNI   D+ +G P L LGL+W II     +DI 
Sbjct: 262 EKGRMRFHRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIH 321

Query: 244 ISRNEALIALLNEGEELEELMKLSPEELLLRWVNYHLTNAGWHTISNFSQDIKDSRAYFH 303
           ++          E E+      +S +E LL W              NF+   +D + +  
Sbjct: 322 VT---------GESED------MSAKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNA 366

Query: 304 LLNQIAPKGGEDGPAIAIDLSGINETNDLKRAGLMLQEADKLGCKQFVTPADVVSGNP-- 361
           ++++  P          ID++ +   ++L         A+K+G  + + P DV   +P  
Sbjct: 367 IIHKYRPD--------LIDMNTVAVQSNLANLEHAFYVAEKIGVIRLLDPEDVDVSSPDE 418

Query: 362 KLNLAFVANLFNTYPCLHKPNN----NDIDMNLLE 392
           K  + +V++L++ +P + +       ND+++  +E
Sbjct: 419 KSVITYVSSLYDAFPKVPEGGEGIGANDVEVKWIE 453



 Score = 68.6 bits (166), Expect = 2e-11
 Identities = 58/236 (24%), Positives = 110/236 (46%), Gaps = 24/236 (10%)

Query: 392 EGESKEERTFRNWMNS--LGVNPYINHLYSDLADALVIFQLYEMIRVPVNWSHVNKPPYP 449
           E +  +++TF  W+N   + V  ++N LY DL D   +  L E++         +    P
Sbjct: 210 ERDKVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEVL---------SGDTLP 260

Query: 450 ALGGNMK--KIENCNYAVELGKNKAKFSLVGIAGQDLNEGNSTLTLALVWQLMRRYTLNV 507
              G M+  +++N   A++  K + +  LV I   D+ +GN  LTL L+W ++  + ++ 
Sbjct: 261 REKGRMRFHRLQNVQIALDYLKRR-QVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISD 319

Query: 508 LSDLGEGEKVN-DEIIIKWVNQTLKSANKKTSISSFKDKSISTSLPVLDLIDAIAPNAVR 566
           +   GE E ++  E ++ W  Q  +        +  + ++ +T      L +AI  +  R
Sbjct: 320 IHVTGESEDMSAKERLLLWTQQATE------GYAGIRCENFTTCWRDGKLFNAII-HKYR 372

Query: 567 QEMIRRENLSDEDKLNNAKYAISVARKIGARIYALPDDLVEVKP--KMVMTVFACL 620
            ++I    ++ +  L N ++A  VA KIG      P+D+    P  K V+T  + L
Sbjct: 373 PDLIDMNTVAVQSNLANLEHAFYVAEKIGVIRLLDPEDVDVSSPDEKSVITYVSSL 428


>gi|34577047 dystonin isoform 1 [Homo sapiens]
          Length = 5497

 Score = 70.9 bits (172), Expect = 3e-12
 Identities = 62/275 (22%), Positives = 120/275 (43%), Gaps = 42/275 (15%)

Query: 124 EKVAFVNWINKALENDPDCKHLIPMNPNDDSLFKSLADGILLCKMINLSEPDTIDERAIN 183
           +K  F  WIN+         HL+ +  + + L++ L DG  L  ++ +   DT+      
Sbjct: 37  QKKTFTKWINQ---------HLMKVRKHVNDLYEDLRDGHNLISLLEVLSGDTLPR---- 83

Query: 184 KKKLTPFTISENLNLALNSASAIGCTVVNIGASDLKEGKPHLVLGLLWQIIKVGLFADIE 243
           +K    F   +N+ +AL+        +VNI   D+ +G P L LGL+W II     +DI 
Sbjct: 84  EKGRMRFHRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIH 143

Query: 244 ISRNEALIALLNEGEELEELMKLSPEELLLRWVNYHLTNAGWHTISNFSQDIKDSRAYFH 303
           ++          E E+      +S +E LL W              NF+   +D + +  
Sbjct: 144 VT---------GESED------MSAKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNA 188

Query: 304 LLNQIAPKGGEDGPAIAIDLSGINETNDLKRAGLMLQEADKLGCKQFVTPADVVSGNP-- 361
           ++++  P          ID++ +   ++L         A+K+G  + + P DV   +P  
Sbjct: 189 IIHKYRPD--------LIDMNTVAVQSNLANLEHAFYVAEKIGVIRLLDPEDVDVSSPDE 240

Query: 362 KLNLAFVANLFNTYPCLHKPNN----NDIDMNLLE 392
           K  + +V++L++ +P + +       ND+++  +E
Sbjct: 241 KSVITYVSSLYDAFPKVPEGGEGIGANDVEVKWIE 275



 Score = 68.6 bits (166), Expect = 2e-11
 Identities = 58/236 (24%), Positives = 110/236 (46%), Gaps = 24/236 (10%)

Query: 392 EGESKEERTFRNWMNS--LGVNPYINHLYSDLADALVIFQLYEMIRVPVNWSHVNKPPYP 449
           E +  +++TF  W+N   + V  ++N LY DL D   +  L E++         +    P
Sbjct: 32  ERDKVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEVL---------SGDTLP 82

Query: 450 ALGGNMK--KIENCNYAVELGKNKAKFSLVGIAGQDLNEGNSTLTLALVWQLMRRYTLNV 507
              G M+  +++N   A++  K + +  LV I   D+ +GN  LTL L+W ++  + ++ 
Sbjct: 83  REKGRMRFHRLQNVQIALDYLKRR-QVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISD 141

Query: 508 LSDLGEGEKVN-DEIIIKWVNQTLKSANKKTSISSFKDKSISTSLPVLDLIDAIAPNAVR 566
           +   GE E ++  E ++ W  Q  +        +  + ++ +T      L +AI  +  R
Sbjct: 142 IHVTGESEDMSAKERLLLWTQQATE------GYAGIRCENFTTCWRDGKLFNAII-HKYR 194

Query: 567 QEMIRRENLSDEDKLNNAKYAISVARKIGARIYALPDDLVEVKP--KMVMTVFACL 620
            ++I    ++ +  L N ++A  VA KIG      P+D+    P  K V+T  + L
Sbjct: 195 PDLIDMNTVAVQSNLANLEHAFYVAEKIGVIRLLDPEDVDVSSPDEKSVITYVSSL 250


>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
          Length = 4547

 Score = 69.3 bits (168), Expect = 1e-11
 Identities = 62/268 (23%), Positives = 115/268 (42%), Gaps = 39/268 (14%)

Query: 112 SSEGTQHSYSEEEKVAFVNWINKALENDPDCKHLIPMNPNDDSLFKSLADGILLCKMINL 171
           +SEG +      +K  F  W+NK         HLI    +   L++ L DG  L  ++ +
Sbjct: 32  ASEGKKDERDRVQKKTFTKWVNK---------HLIKAQRHISDLYEDLRDGHNLISLLEV 82

Query: 172 SEPDTIDERAINKKKLTPFTISENLNLALNSASAIGCTVVNIGASDLKEGKPHLVLGLLW 231
              D++      +K    F   +N+ +AL+        +VNI   D+ +G P L LGL+W
Sbjct: 83  LSGDSLPR----EKGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIW 138

Query: 232 QIIKVGLFADIEISRNEALIALLNEGEELEELMKLSPEELLLRWVNYHLTNAGWHTISNF 291
            II     +DI++S          + E+      ++ +E LL W    +         NF
Sbjct: 139 TIILHFQISDIQVS---------GQSED------MTAKEKLLLWSQRMVEGYQGLRCDNF 183

Query: 292 SQDIKDSRAYFHLLNQIAPKGGEDGPAIAIDLSGINETNDLKRAGLMLQEADK-LGCKQF 350
           +   +D R +  ++++  P        + ID++ +    +L+        A++ LG  + 
Sbjct: 184 TSSWRDGRLFNAIIHRHKP--------LLIDMNKVYRQTNLENLDQAFSVAERDLGVTRL 235

Query: 351 VTPADVVSGNP--KLNLAFVANLFNTYP 376
           + P DV    P  K  + +V++L++  P
Sbjct: 236 LDPEDVDVPQPDEKSIITYVSSLYDAMP 263



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 54/240 (22%), Positives = 106/240 (44%), Gaps = 31/240 (12%)

Query: 392 EGESKEERTFRNWMNS--LGVNPYINHLYSDLADALVIFQLYEMIRVPVNWSHVNKPPYP 449
           E +  +++TF  W+N   +    +I+ LY DL D   +  L E++         +    P
Sbjct: 39  ERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVL---------SGDSLP 89

Query: 450 ALGGNMK--KIENCNYAVELGKNKAKFSLVGIAGQDLNEGNSTLTLALVWQLMRRYTLNV 507
              G M+  K++N   A++  +++ +  LV I   D+ +GN  LTL L+W ++  + ++ 
Sbjct: 90  REKGRMRFHKLQNVQIALDYLRHR-QVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISD 148

Query: 508 LSDLGEGEKVN-DEIIIKWVNQTL---KSANKKTSISSFKDKSISTSLPVLDLIDAIAPN 563
           +   G+ E +   E ++ W  + +   +        SS++D  +  +     +I    P 
Sbjct: 149 IQVSGQSEDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNA-----IIHRHKPL 203

Query: 564 AVRQEMIRRENLSDEDKLNNAKYAISVA-RKIGARIYALPDDLVEVKP--KMVMTVFACL 620
            +    + R+       L N   A SVA R +G      P+D+   +P  K ++T  + L
Sbjct: 204 LIDMNKVYRQT-----NLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSL 258



 Score = 32.0 bits (71), Expect = 1.8
 Identities = 32/128 (25%), Positives = 54/128 (42%), Gaps = 15/128 (11%)

Query: 245 SRNEALIALLNEGEELEELMKLSPEELLLRWVNYHLTNAGWHTISNFSQDIKDSRAYFHL 304
           S +   +A+L   E  ++      ++   +WVN HL  A  H IS+  +D++D      L
Sbjct: 21  SEDNLYLAVLRASEGKKDERDRVQKKTFTKWVNKHLIKAQRH-ISDLYEDLRDGHNLISL 79

Query: 305 LNQIAPKGGEDGPAIAIDLSGINETNDLKRAGLMLQEADKLGCKQF----VTPADVVSGN 360
           L  ++   G+  P       G    + L+   + L   D L  +Q     +   D+  GN
Sbjct: 80  LEVLS---GDSLPR----EKGRMRFHKLQNVQIAL---DYLRHRQVKLVNIRNDDIADGN 129

Query: 361 PKLNLAFV 368
           PKL L  +
Sbjct: 130 PKLTLGLI 137


>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
          Length = 4533

 Score = 66.2 bits (160), Expect = 8e-11
 Identities = 62/270 (22%), Positives = 115/270 (42%), Gaps = 43/270 (15%)

Query: 114 EGTQHSYSEE----EKVAFVNWINKALENDPDCKHLIPMNPNDDSLFKSLADGILLCKMI 169
           E  +  Y +E    +K  F  W+NK         HLI    +   L++ L DG  L  ++
Sbjct: 16  EEVREKYKDERDRVQKKTFTKWVNK---------HLIKAQRHISDLYEDLRDGHNLISLL 66

Query: 170 NLSEPDTIDERAINKKKLTPFTISENLNLALNSASAIGCTVVNIGASDLKEGKPHLVLGL 229
            +   D++      +K    F   +N+ +AL+        +VNI   D+ +G P L LGL
Sbjct: 67  EVLSGDSLPR----EKGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGL 122

Query: 230 LWQIIKVGLFADIEISRNEALIALLNEGEELEELMKLSPEELLLRWVNYHLTNAGWHTIS 289
           +W II     +DI++S          + E+      ++ +E LL W    +         
Sbjct: 123 IWTIILHFQISDIQVS---------GQSED------MTAKEKLLLWSQRMVEGYQGLRCD 167

Query: 290 NFSQDIKDSRAYFHLLNQIAPKGGEDGPAIAIDLSGINETNDLKRAGLMLQEADK-LGCK 348
           NF+   +D R +  ++++  P        + ID++ +    +L+        A++ LG  
Sbjct: 168 NFTSSWRDGRLFNAIIHRHKP--------LLIDMNKVYRQTNLENLDQAFSVAERDLGVT 219

Query: 349 QFVTPADVVSGNP--KLNLAFVANLFNTYP 376
           + + P DV    P  K  + +V++L++  P
Sbjct: 220 RLLDPEDVDVPQPDEKSIITYVSSLYDAMP 249



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 54/240 (22%), Positives = 106/240 (44%), Gaps = 31/240 (12%)

Query: 392 EGESKEERTFRNWMNS--LGVNPYINHLYSDLADALVIFQLYEMIRVPVNWSHVNKPPYP 449
           E +  +++TF  W+N   +    +I+ LY DL D   +  L E++         +    P
Sbjct: 25  ERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVL---------SGDSLP 75

Query: 450 ALGGNMK--KIENCNYAVELGKNKAKFSLVGIAGQDLNEGNSTLTLALVWQLMRRYTLNV 507
              G M+  K++N   A++  +++ +  LV I   D+ +GN  LTL L+W ++  + ++ 
Sbjct: 76  REKGRMRFHKLQNVQIALDYLRHR-QVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISD 134

Query: 508 LSDLGEGEKVN-DEIIIKWVNQTL---KSANKKTSISSFKDKSISTSLPVLDLIDAIAPN 563
           +   G+ E +   E ++ W  + +   +        SS++D  +  +     +I    P 
Sbjct: 135 IQVSGQSEDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNA-----IIHRHKPL 189

Query: 564 AVRQEMIRRENLSDEDKLNNAKYAISVA-RKIGARIYALPDDLVEVKP--KMVMTVFACL 620
            +    + R+       L N   A SVA R +G      P+D+   +P  K ++T  + L
Sbjct: 190 LIDMNKVYRQT-----NLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSL 244


>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
          Length = 4547

 Score = 65.5 bits (158), Expect = 1e-10
 Identities = 60/267 (22%), Positives = 113/267 (42%), Gaps = 39/267 (14%)

Query: 113 SEGTQHSYSEEEKVAFVNWINKALENDPDCKHLIPMNPNDDSLFKSLADGILLCKMINLS 172
           ++  Q      +K  F  W+NK         HLI    +   L++ L DG  L  ++ + 
Sbjct: 33  AQDEQDERDRVQKKTFTKWVNK---------HLIKAQRHISDLYEDLRDGHNLISLLEVL 83

Query: 173 EPDTIDERAINKKKLTPFTISENLNLALNSASAIGCTVVNIGASDLKEGKPHLVLGLLWQ 232
             D++      +K    F   +N+ +AL+        +VNI   D+ +G P L LGL+W 
Sbjct: 84  SGDSLPR----EKGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWT 139

Query: 233 IIKVGLFADIEISRNEALIALLNEGEELEELMKLSPEELLLRWVNYHLTNAGWHTISNFS 292
           II     +DI++S          + E+      ++ +E LL W    +         NF+
Sbjct: 140 IILHFQISDIQVS---------GQSED------MTAKEKLLLWSQRMVEGYQGLRCDNFT 184

Query: 293 QDIKDSRAYFHLLNQIAPKGGEDGPAIAIDLSGINETNDLKRAGLMLQEADK-LGCKQFV 351
              +D R +  ++++  P        + ID++ +    +L+        A++ LG  + +
Sbjct: 185 SSWRDGRLFNAIIHRHKP--------LLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLL 236

Query: 352 TPADVVSGNP--KLNLAFVANLFNTYP 376
            P DV    P  K  + +V++L++  P
Sbjct: 237 DPEDVDVPQPDEKSIITYVSSLYDAMP 263



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 54/240 (22%), Positives = 106/240 (44%), Gaps = 31/240 (12%)

Query: 392 EGESKEERTFRNWMNS--LGVNPYINHLYSDLADALVIFQLYEMIRVPVNWSHVNKPPYP 449
           E +  +++TF  W+N   +    +I+ LY DL D   +  L E++         +    P
Sbjct: 39  ERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVL---------SGDSLP 89

Query: 450 ALGGNMK--KIENCNYAVELGKNKAKFSLVGIAGQDLNEGNSTLTLALVWQLMRRYTLNV 507
              G M+  K++N   A++  +++ +  LV I   D+ +GN  LTL L+W ++  + ++ 
Sbjct: 90  REKGRMRFHKLQNVQIALDYLRHR-QVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISD 148

Query: 508 LSDLGEGEKVN-DEIIIKWVNQTL---KSANKKTSISSFKDKSISTSLPVLDLIDAIAPN 563
           +   G+ E +   E ++ W  + +   +        SS++D  +  +     +I    P 
Sbjct: 149 IQVSGQSEDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNA-----IIHRHKPL 203

Query: 564 AVRQEMIRRENLSDEDKLNNAKYAISVA-RKIGARIYALPDDLVEVKP--KMVMTVFACL 620
            +    + R+       L N   A SVA R +G      P+D+   +P  K ++T  + L
Sbjct: 204 LIDMNKVYRQT-----NLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSL 258


>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
          Length = 4551

 Score = 65.1 bits (157), Expect = 2e-10
 Identities = 59/256 (23%), Positives = 110/256 (42%), Gaps = 39/256 (15%)

Query: 124 EKVAFVNWINKALENDPDCKHLIPMNPNDDSLFKSLADGILLCKMINLSEPDTIDERAIN 183
           +K  F  W+NK         HLI    +   L++ L DG  L  ++ +   D++      
Sbjct: 48  QKKTFTKWVNK---------HLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPR---- 94

Query: 184 KKKLTPFTISENLNLALNSASAIGCTVVNIGASDLKEGKPHLVLGLLWQIIKVGLFADIE 243
           +K    F   +N+ +AL+        +VNI   D+ +G P L LGL+W II     +DI+
Sbjct: 95  EKGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQ 154

Query: 244 ISRNEALIALLNEGEELEELMKLSPEELLLRWVNYHLTNAGWHTISNFSQDIKDSRAYFH 303
           +S          + E+      ++ +E LL W    +         NF+   +D R +  
Sbjct: 155 VS---------GQSED------MTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNA 199

Query: 304 LLNQIAPKGGEDGPAIAIDLSGINETNDLKRAGLMLQEADK-LGCKQFVTPADVVSGNP- 361
           ++++  P        + ID++ +    +L+        A++ LG  + + P DV    P 
Sbjct: 200 IIHRHKP--------LLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPD 251

Query: 362 -KLNLAFVANLFNTYP 376
            K  + +V++L++  P
Sbjct: 252 EKSIITYVSSLYDAMP 267



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 54/240 (22%), Positives = 106/240 (44%), Gaps = 31/240 (12%)

Query: 392 EGESKEERTFRNWMNS--LGVNPYINHLYSDLADALVIFQLYEMIRVPVNWSHVNKPPYP 449
           E +  +++TF  W+N   +    +I+ LY DL D   +  L E++         +    P
Sbjct: 43  ERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVL---------SGDSLP 93

Query: 450 ALGGNMK--KIENCNYAVELGKNKAKFSLVGIAGQDLNEGNSTLTLALVWQLMRRYTLNV 507
              G M+  K++N   A++  +++ +  LV I   D+ +GN  LTL L+W ++  + ++ 
Sbjct: 94  REKGRMRFHKLQNVQIALDYLRHR-QVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISD 152

Query: 508 LSDLGEGEKVN-DEIIIKWVNQTL---KSANKKTSISSFKDKSISTSLPVLDLIDAIAPN 563
           +   G+ E +   E ++ W  + +   +        SS++D  +  +     +I    P 
Sbjct: 153 IQVSGQSEDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNA-----IIHRHKPL 207

Query: 564 AVRQEMIRRENLSDEDKLNNAKYAISVA-RKIGARIYALPDDLVEVKP--KMVMTVFACL 620
            +    + R+       L N   A SVA R +G      P+D+   +P  K ++T  + L
Sbjct: 208 LIDMNKVYRQT-----NLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSL 262


>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
          Length = 4515

 Score = 65.1 bits (157), Expect = 2e-10
 Identities = 59/256 (23%), Positives = 110/256 (42%), Gaps = 39/256 (15%)

Query: 124 EKVAFVNWINKALENDPDCKHLIPMNPNDDSLFKSLADGILLCKMINLSEPDTIDERAIN 183
           +K  F  W+NK         HLI    +   L++ L DG  L  ++ +   D++      
Sbjct: 12  QKKTFTKWVNK---------HLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPR---- 58

Query: 184 KKKLTPFTISENLNLALNSASAIGCTVVNIGASDLKEGKPHLVLGLLWQIIKVGLFADIE 243
           +K    F   +N+ +AL+        +VNI   D+ +G P L LGL+W II     +DI+
Sbjct: 59  EKGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQ 118

Query: 244 ISRNEALIALLNEGEELEELMKLSPEELLLRWVNYHLTNAGWHTISNFSQDIKDSRAYFH 303
           +S          + E+      ++ +E LL W    +         NF+   +D R +  
Sbjct: 119 VS---------GQSED------MTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNA 163

Query: 304 LLNQIAPKGGEDGPAIAIDLSGINETNDLKRAGLMLQEADK-LGCKQFVTPADVVSGNP- 361
           ++++  P        + ID++ +    +L+        A++ LG  + + P DV    P 
Sbjct: 164 IIHRHKP--------LLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPD 215

Query: 362 -KLNLAFVANLFNTYP 376
            K  + +V++L++  P
Sbjct: 216 EKSIITYVSSLYDAMP 231



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 54/240 (22%), Positives = 106/240 (44%), Gaps = 31/240 (12%)

Query: 392 EGESKEERTFRNWMNS--LGVNPYINHLYSDLADALVIFQLYEMIRVPVNWSHVNKPPYP 449
           E +  +++TF  W+N   +    +I+ LY DL D   +  L E++         +    P
Sbjct: 7   ERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVL---------SGDSLP 57

Query: 450 ALGGNMK--KIENCNYAVELGKNKAKFSLVGIAGQDLNEGNSTLTLALVWQLMRRYTLNV 507
              G M+  K++N   A++  +++ +  LV I   D+ +GN  LTL L+W ++  + ++ 
Sbjct: 58  REKGRMRFHKLQNVQIALDYLRHR-QVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISD 116

Query: 508 LSDLGEGEKVN-DEIIIKWVNQTL---KSANKKTSISSFKDKSISTSLPVLDLIDAIAPN 563
           +   G+ E +   E ++ W  + +   +        SS++D  +  +     +I    P 
Sbjct: 117 IQVSGQSEDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNA-----IIHRHKPL 171

Query: 564 AVRQEMIRRENLSDEDKLNNAKYAISVA-RKIGARIYALPDDLVEVKP--KMVMTVFACL 620
            +    + R+       L N   A SVA R +G      P+D+   +P  K ++T  + L
Sbjct: 172 LIDMNKVYRQT-----NLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSL 226


>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
          Length = 4684

 Score = 65.1 bits (157), Expect = 2e-10
 Identities = 59/256 (23%), Positives = 110/256 (42%), Gaps = 39/256 (15%)

Query: 124 EKVAFVNWINKALENDPDCKHLIPMNPNDDSLFKSLADGILLCKMINLSEPDTIDERAIN 183
           +K  F  W+NK         HLI    +   L++ L DG  L  ++ +   D++      
Sbjct: 181 QKKTFTKWVNK---------HLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPR---- 227

Query: 184 KKKLTPFTISENLNLALNSASAIGCTVVNIGASDLKEGKPHLVLGLLWQIIKVGLFADIE 243
           +K    F   +N+ +AL+        +VNI   D+ +G P L LGL+W II     +DI+
Sbjct: 228 EKGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQ 287

Query: 244 ISRNEALIALLNEGEELEELMKLSPEELLLRWVNYHLTNAGWHTISNFSQDIKDSRAYFH 303
           +S          + E+      ++ +E LL W    +         NF+   +D R +  
Sbjct: 288 VS---------GQSED------MTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNA 332

Query: 304 LLNQIAPKGGEDGPAIAIDLSGINETNDLKRAGLMLQEADK-LGCKQFVTPADVVSGNP- 361
           ++++  P        + ID++ +    +L+        A++ LG  + + P DV    P 
Sbjct: 333 IIHRHKP--------LLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPD 384

Query: 362 -KLNLAFVANLFNTYP 376
            K  + +V++L++  P
Sbjct: 385 EKSIITYVSSLYDAMP 400



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 54/240 (22%), Positives = 106/240 (44%), Gaps = 31/240 (12%)

Query: 392 EGESKEERTFRNWMNS--LGVNPYINHLYSDLADALVIFQLYEMIRVPVNWSHVNKPPYP 449
           E +  +++TF  W+N   +    +I+ LY DL D   +  L E++         +    P
Sbjct: 176 ERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVL---------SGDSLP 226

Query: 450 ALGGNMK--KIENCNYAVELGKNKAKFSLVGIAGQDLNEGNSTLTLALVWQLMRRYTLNV 507
              G M+  K++N   A++  +++ +  LV I   D+ +GN  LTL L+W ++  + ++ 
Sbjct: 227 REKGRMRFHKLQNVQIALDYLRHR-QVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISD 285

Query: 508 LSDLGEGEKVN-DEIIIKWVNQTL---KSANKKTSISSFKDKSISTSLPVLDLIDAIAPN 563
           +   G+ E +   E ++ W  + +   +        SS++D  +  +     +I    P 
Sbjct: 286 IQVSGQSEDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNA-----IIHRHKPL 340

Query: 564 AVRQEMIRRENLSDEDKLNNAKYAISVA-RKIGARIYALPDDLVEVKP--KMVMTVFACL 620
            +    + R+       L N   A SVA R +G      P+D+   +P  K ++T  + L
Sbjct: 341 LIDMNKVYRQT-----NLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSL 395


>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
          Length = 4525

 Score = 65.1 bits (157), Expect = 2e-10
 Identities = 59/256 (23%), Positives = 110/256 (42%), Gaps = 39/256 (15%)

Query: 124 EKVAFVNWINKALENDPDCKHLIPMNPNDDSLFKSLADGILLCKMINLSEPDTIDERAIN 183
           +K  F  W+NK         HLI    +   L++ L DG  L  ++ +   D++      
Sbjct: 22  QKKTFTKWVNK---------HLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPR---- 68

Query: 184 KKKLTPFTISENLNLALNSASAIGCTVVNIGASDLKEGKPHLVLGLLWQIIKVGLFADIE 243
           +K    F   +N+ +AL+        +VNI   D+ +G P L LGL+W II     +DI+
Sbjct: 69  EKGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQ 128

Query: 244 ISRNEALIALLNEGEELEELMKLSPEELLLRWVNYHLTNAGWHTISNFSQDIKDSRAYFH 303
           +S          + E+      ++ +E LL W    +         NF+   +D R +  
Sbjct: 129 VS---------GQSED------MTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNA 173

Query: 304 LLNQIAPKGGEDGPAIAIDLSGINETNDLKRAGLMLQEADK-LGCKQFVTPADVVSGNP- 361
           ++++  P        + ID++ +    +L+        A++ LG  + + P DV    P 
Sbjct: 174 IIHRHKP--------LLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPD 225

Query: 362 -KLNLAFVANLFNTYP 376
            K  + +V++L++  P
Sbjct: 226 EKSIITYVSSLYDAMP 241



 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 56/248 (22%), Positives = 109/248 (43%), Gaps = 31/248 (12%)

Query: 384 NDIDMNLLEGESKEERTFRNWMNS--LGVNPYINHLYSDLADALVIFQLYEMIRVPVNWS 441
           N+I     E +  +++TF  W+N   +    +I+ LY DL D   +  L E++       
Sbjct: 9   NEISSLKDERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVL------- 61

Query: 442 HVNKPPYPALGGNMK--KIENCNYAVELGKNKAKFSLVGIAGQDLNEGNSTLTLALVWQL 499
             +    P   G M+  K++N   A++  +++ +  LV I   D+ +GN  LTL L+W +
Sbjct: 62  --SGDSLPREKGRMRFHKLQNVQIALDYLRHR-QVKLVNIRNDDIADGNPKLTLGLIWTI 118

Query: 500 MRRYTLNVLSDLGEGEKVN-DEIIIKWVNQTL---KSANKKTSISSFKDKSISTSLPVLD 555
           +  + ++ +   G+ E +   E ++ W  + +   +        SS++D  +  +     
Sbjct: 119 ILHFQISDIQVSGQSEDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNA----- 173

Query: 556 LIDAIAPNAVRQEMIRRENLSDEDKLNNAKYAISVA-RKIGARIYALPDDLVEVKP--KM 612
           +I    P  +    + R+       L N   A SVA R +G      P+D+   +P  K 
Sbjct: 174 IIHRHKPLLIDMNKVYRQT-----NLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKS 228

Query: 613 VMTVFACL 620
           ++T  + L
Sbjct: 229 IITYVSSL 236



 Score = 32.3 bits (72), Expect = 1.4
 Identities = 32/121 (26%), Positives = 52/121 (42%), Gaps = 15/121 (12%)

Query: 252 ALLNEGEELEELMKLSPEELLLRWVNYHLTNAGWHTISNFSQDIKDSRAYFHLLNQIAPK 311
           A+ NE   L++      ++   +WVN HL  A  H IS+  +D++D      LL  ++  
Sbjct: 6   AIQNEISSLKDERDRVQKKTFTKWVNKHLIKAQRH-ISDLYEDLRDGHNLISLLEVLS-- 62

Query: 312 GGEDGPAIAIDLSGINETNDLKRAGLMLQEADKLGCKQF----VTPADVVSGNPKLNLAF 367
            G+  P       G    + L+   + L   D L  +Q     +   D+  GNPKL L  
Sbjct: 63  -GDSLPR----EKGRMRFHKLQNVQIAL---DYLRHRQVKLVNIRNDDIADGNPKLTLGL 114

Query: 368 V 368
           +
Sbjct: 115 I 115


>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
          Length = 4574

 Score = 65.1 bits (157), Expect = 2e-10
 Identities = 59/256 (23%), Positives = 110/256 (42%), Gaps = 39/256 (15%)

Query: 124 EKVAFVNWINKALENDPDCKHLIPMNPNDDSLFKSLADGILLCKMINLSEPDTIDERAIN 183
           +K  F  W+NK         HLI    +   L++ L DG  L  ++ +   D++      
Sbjct: 71  QKKTFTKWVNK---------HLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPR---- 117

Query: 184 KKKLTPFTISENLNLALNSASAIGCTVVNIGASDLKEGKPHLVLGLLWQIIKVGLFADIE 243
           +K    F   +N+ +AL+        +VNI   D+ +G P L LGL+W II     +DI+
Sbjct: 118 EKGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQ 177

Query: 244 ISRNEALIALLNEGEELEELMKLSPEELLLRWVNYHLTNAGWHTISNFSQDIKDSRAYFH 303
           +S          + E+      ++ +E LL W    +         NF+   +D R +  
Sbjct: 178 VS---------GQSED------MTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNA 222

Query: 304 LLNQIAPKGGEDGPAIAIDLSGINETNDLKRAGLMLQEADK-LGCKQFVTPADVVSGNP- 361
           ++++  P        + ID++ +    +L+        A++ LG  + + P DV    P 
Sbjct: 223 IIHRHKP--------LLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPD 274

Query: 362 -KLNLAFVANLFNTYP 376
            K  + +V++L++  P
Sbjct: 275 EKSIITYVSSLYDAMP 290



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 54/240 (22%), Positives = 106/240 (44%), Gaps = 31/240 (12%)

Query: 392 EGESKEERTFRNWMNS--LGVNPYINHLYSDLADALVIFQLYEMIRVPVNWSHVNKPPYP 449
           E +  +++TF  W+N   +    +I+ LY DL D   +  L E++         +    P
Sbjct: 66  ERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVL---------SGDSLP 116

Query: 450 ALGGNMK--KIENCNYAVELGKNKAKFSLVGIAGQDLNEGNSTLTLALVWQLMRRYTLNV 507
              G M+  K++N   A++  +++ +  LV I   D+ +GN  LTL L+W ++  + ++ 
Sbjct: 117 REKGRMRFHKLQNVQIALDYLRHR-QVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISD 175

Query: 508 LSDLGEGEKVN-DEIIIKWVNQTL---KSANKKTSISSFKDKSISTSLPVLDLIDAIAPN 563
           +   G+ E +   E ++ W  + +   +        SS++D  +  +     +I    P 
Sbjct: 176 IQVSGQSEDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNA-----IIHRHKPL 230

Query: 564 AVRQEMIRRENLSDEDKLNNAKYAISVA-RKIGARIYALPDDLVEVKP--KMVMTVFACL 620
            +    + R+       L N   A SVA R +G      P+D+   +P  K ++T  + L
Sbjct: 231 LIDMNKVYRQT-----NLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSL 285


>gi|169218211 PREDICTED: similar to plectin 1, partial [Homo
           sapiens]
          Length = 1369

 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 58/256 (22%), Positives = 109/256 (42%), Gaps = 39/256 (15%)

Query: 124 EKVAFVNWINKALENDPDCKHLIPMNPNDDSLFKSLADGILLCKMINLSEPDTIDERAIN 183
           +K     W+NK         HLI    +   L++ L DG  L  ++ +   D++      
Sbjct: 177 QKKTSTKWVNK---------HLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPR---- 223

Query: 184 KKKLTPFTISENLNLALNSASAIGCTVVNIGASDLKEGKPHLVLGLLWQIIKVGLFADIE 243
           +K    F   +N+ +AL+        +VNI   D+ +G P L LGL+W II     +DI+
Sbjct: 224 EKGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQ 283

Query: 244 ISRNEALIALLNEGEELEELMKLSPEELLLRWVNYHLTNAGWHTISNFSQDIKDSRAYFH 303
           +S          + E+      ++ +E LL W    +         NF+   +D R +  
Sbjct: 284 VS---------GQSED------MTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNA 328

Query: 304 LLNQIAPKGGEDGPAIAIDLSGINETNDLKRAGLMLQEADK-LGCKQFVTPADVVSGNP- 361
           ++++  P        + ID++ +    +L+        A++ LG  + + P DV    P 
Sbjct: 329 IIHRHKP--------LLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPD 380

Query: 362 -KLNLAFVANLFNTYP 376
            K  + +V++L++  P
Sbjct: 381 EKSIITYVSSLYDAMP 396



 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 53/240 (22%), Positives = 105/240 (43%), Gaps = 31/240 (12%)

Query: 392 EGESKEERTFRNWMNS--LGVNPYINHLYSDLADALVIFQLYEMIRVPVNWSHVNKPPYP 449
           E +  +++T   W+N   +    +I+ LY DL D   +  L E++         +    P
Sbjct: 172 ERDRVQKKTSTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVL---------SGDSLP 222

Query: 450 ALGGNMK--KIENCNYAVELGKNKAKFSLVGIAGQDLNEGNSTLTLALVWQLMRRYTLNV 507
              G M+  K++N   A++  +++ +  LV I   D+ +GN  LTL L+W ++  + ++ 
Sbjct: 223 REKGRMRFHKLQNVQIALDYLRHR-QVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISD 281

Query: 508 LSDLGEGEKVN-DEIIIKWVNQTL---KSANKKTSISSFKDKSISTSLPVLDLIDAIAPN 563
           +   G+ E +   E ++ W  + +   +        SS++D  +  +     +I    P 
Sbjct: 282 IQVSGQSEDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNA-----IIHRHKPL 336

Query: 564 AVRQEMIRRENLSDEDKLNNAKYAISVA-RKIGARIYALPDDLVEVKP--KMVMTVFACL 620
            +    + R+       L N   A SVA R +G      P+D+   +P  K ++T  + L
Sbjct: 337 LIDMNKVYRQT-----NLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSL 391


>gi|33188445 microfilament and actin filament cross-linker protein
           isoform a [Homo sapiens]
          Length = 5430

 Score = 61.2 bits (147), Expect = 3e-09
 Identities = 60/257 (23%), Positives = 112/257 (43%), Gaps = 42/257 (16%)

Query: 124 EKVAFVNWINKALENDPDCKHLIPMNPNDDSLFKSLADGILLCKMINLSEPDTIDERAIN 183
           +K  F  W+NK         HL+ +  + + L++ L DG  L  ++ +     +      
Sbjct: 80  QKKTFTKWVNK---------HLMKVRKHINDLYEDLRDGHNLISLLEVLSGIKLPR---- 126

Query: 184 KKKLTPFTISENLNLALNSASAIGCTVVNIGASDLKEGKPHLVLGLLWQIIKVGLFADIE 243
           +K    F   +N+ +AL+        +VNI   D+ +G P L LGL+W II     +DI 
Sbjct: 127 EKGRMRFHRLQNVQIALDFLKQRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIY 186

Query: 244 ISRNEALIALLNEGEELEELMKLSPEELLLRWVNYHLTNAGWHTI--SNFSQDIKDSRAY 301
           IS           GE  +    +S +E LL W       AG+  I  +NFS    D + +
Sbjct: 187 IS-----------GESGD----MSAKEKLLLWT--QKVTAGYTGIKCTNFSSCWSDGKMF 229

Query: 302 FHLLNQIAPKGGEDGPAIAIDLSGINETNDLKRAGLMLQEADKLGCKQFV--TPADVVSG 359
             L+++  P          +D+  +   ++ +      + A++LG  + +     DV S 
Sbjct: 230 NALIHRYRPD--------LVDMERVQIQSNRENLEQAFEVAERLGVTRLLDAEDVDVPSP 281

Query: 360 NPKLNLAFVANLFNTYP 376
           + K  + +V+++++ +P
Sbjct: 282 DEKSVITYVSSIYDAFP 298



 Score = 57.8 bits (138), Expect = 3e-08
 Identities = 47/209 (22%), Positives = 94/209 (44%), Gaps = 22/209 (10%)

Query: 392 EGESKEERTFRNWMNS--LGVNPYINHLYSDLADALVIFQLYEMIRVPVNWSHVNKPPYP 449
           E +  +++TF  W+N   + V  +IN LY DL D   +  L E++         +    P
Sbjct: 75  ERDRVQKKTFTKWVNKHLMKVRKHINDLYEDLRDGHNLISLLEVL---------SGIKLP 125

Query: 450 ALGGNMK--KIENCNYAVELGKNKAKFSLVGIAGQDLNEGNSTLTLALVWQLMRRYTLNV 507
              G M+  +++N   A++  K + +  LV I   D+ +GN  LTL L+W ++  + ++ 
Sbjct: 126 REKGRMRFHRLQNVQIALDFLKQR-QVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISD 184

Query: 508 LSDLGE-GEKVNDEIIIKWVNQTLKSANKKTSISSFKDKSISTSLPVLDLIDAIAPNAVR 566
           +   GE G+    E ++ W  +           +  K  + S+      + +A+  +  R
Sbjct: 185 IYISGESGDMSAKEKLLLWTQKV------TAGYTGIKCTNFSSCWSDGKMFNALI-HRYR 237

Query: 567 QEMIRRENLSDEDKLNNAKYAISVARKIG 595
            +++  E +  +    N + A  VA ++G
Sbjct: 238 PDLVDMERVQIQSNRENLEQAFEVAERLG 266



 Score = 29.6 bits (65), Expect = 8.8
 Identities = 18/55 (32%), Positives = 31/55 (56%), Gaps = 6/55 (10%)

Query: 253  LLNEGEELEELMKLSPEELLLRWVNYHLTNAGWHTISNFSQDIKDSRAYFHLLNQ 307
            LL +G E+    KLS EE++L   +     A W T+ ++  D+KD  + F +L++
Sbjct: 1171 LLVKGYEI----KLSQEEVVL--ADLSALEAHWSTLRHWLSDVKDKNSVFSVLDE 1219


>gi|160420317 filamin A, alpha isoform 2 [Homo sapiens]
          Length = 2647

 Score = 60.8 bits (146), Expect = 4e-09
 Identities = 61/264 (23%), Positives = 114/264 (43%), Gaps = 40/264 (15%)

Query: 106 GGTSTISSE--GTQHSYSEE------EKVAFVNWINKALENDPDCKHLIPMNPNDDSLFK 157
           GG  T  +E   T+   +E+      ++  F  W N+         HL  ++    +L  
Sbjct: 19  GGVDTRDAEMPATEKDLAEDAPWKKIQQNTFTRWCNE---------HLKCVSKRIANLQT 69

Query: 158 SLADGILLCKMINLSEPDTIDERAINKKKLTPFTISENLNLALNSASAIGCTVVNIGASD 217
            L+DG+ L  ++ +     +  +   +       + EN+++AL         +V+I +  
Sbjct: 70  DLSDGLRLIALLEVLSQKKMHRKHNQRPTFRQMQL-ENVSVALEFLDRESIKLVSIDSKA 128

Query: 218 LKEGKPHLVLGLLWQIIKVGLFADIEISRNEALIALLNEGEELEELMKLSPEELLLRWVN 277
           + +G   L+LGL+W +I            + ++   + + EE EE  K +P++ LL W+ 
Sbjct: 129 IVDGNLKLILGLIWTLI-----------LHYSISMPMWDEEEDEEAKKQTPKQRLLGWIQ 177

Query: 278 YHLTNAGWHTISNFSQDIKDSRAYFHLLNQIAPKGGEDGPAIAIDLSGINETNDLKRAGL 337
             L       I+NFS+D +  RA   L++  A       P +  D    + +  +  A  
Sbjct: 178 NKLPQL---PITNFSRDWQSGRALGALVDSCA-------PGLCPDWDSWDASKPVTNARE 227

Query: 338 MLQEADK-LGCKQFVTPADVVSGN 360
            +Q+AD  LG  Q +TP ++V  N
Sbjct: 228 AMQQADDWLGIPQVITPEEIVDPN 251



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 35/142 (24%), Positives = 71/142 (50%), Gaps = 14/142 (9%)

Query: 397 EERTFRNWMNS--LGVNPYINHLYSDLADALVIFQLYEMI-RVPVNWSHVNKPPYPALGG 453
           ++ TF  W N     V+  I +L +DL+D L +  L E++ +  ++  H  +P +  +  
Sbjct: 45  QQNTFTRWCNEHLKCVSKRIANLQTDLSDGLRLIALLEVLSQKKMHRKHNQRPTFRQM-- 102

Query: 454 NMKKIENCNYAVELGKNKAKFSLVGIAGQDLNEGNSTLTLALVWQLMRRYTLNV-LSDLG 512
              ++EN + A+E   ++    LV I  + + +GN  L L L+W L+  Y++++ + D  
Sbjct: 103 ---QLENVSVALEF-LDRESIKLVSIDSKAIVDGNLKLILGLIWTLILHYSISMPMWDEE 158

Query: 513 EGEKVNDEI----IIKWVNQTL 530
           E E+   +     ++ W+   L
Sbjct: 159 EDEEAKKQTPKQRLLGWIQNKL 180


>gi|116063573 filamin A, alpha isoform 1 [Homo sapiens]
          Length = 2639

 Score = 60.8 bits (146), Expect = 4e-09
 Identities = 61/264 (23%), Positives = 114/264 (43%), Gaps = 40/264 (15%)

Query: 106 GGTSTISSE--GTQHSYSEE------EKVAFVNWINKALENDPDCKHLIPMNPNDDSLFK 157
           GG  T  +E   T+   +E+      ++  F  W N+         HL  ++    +L  
Sbjct: 19  GGVDTRDAEMPATEKDLAEDAPWKKIQQNTFTRWCNE---------HLKCVSKRIANLQT 69

Query: 158 SLADGILLCKMINLSEPDTIDERAINKKKLTPFTISENLNLALNSASAIGCTVVNIGASD 217
            L+DG+ L  ++ +     +  +   +       + EN+++AL         +V+I +  
Sbjct: 70  DLSDGLRLIALLEVLSQKKMHRKHNQRPTFRQMQL-ENVSVALEFLDRESIKLVSIDSKA 128

Query: 218 LKEGKPHLVLGLLWQIIKVGLFADIEISRNEALIALLNEGEELEELMKLSPEELLLRWVN 277
           + +G   L+LGL+W +I            + ++   + + EE EE  K +P++ LL W+ 
Sbjct: 129 IVDGNLKLILGLIWTLI-----------LHYSISMPMWDEEEDEEAKKQTPKQRLLGWIQ 177

Query: 278 YHLTNAGWHTISNFSQDIKDSRAYFHLLNQIAPKGGEDGPAIAIDLSGINETNDLKRAGL 337
             L       I+NFS+D +  RA   L++  A       P +  D    + +  +  A  
Sbjct: 178 NKLPQL---PITNFSRDWQSGRALGALVDSCA-------PGLCPDWDSWDASKPVTNARE 227

Query: 338 MLQEADK-LGCKQFVTPADVVSGN 360
            +Q+AD  LG  Q +TP ++V  N
Sbjct: 228 AMQQADDWLGIPQVITPEEIVDPN 251



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 35/142 (24%), Positives = 71/142 (50%), Gaps = 14/142 (9%)

Query: 397 EERTFRNWMNS--LGVNPYINHLYSDLADALVIFQLYEMI-RVPVNWSHVNKPPYPALGG 453
           ++ TF  W N     V+  I +L +DL+D L +  L E++ +  ++  H  +P +  +  
Sbjct: 45  QQNTFTRWCNEHLKCVSKRIANLQTDLSDGLRLIALLEVLSQKKMHRKHNQRPTFRQM-- 102

Query: 454 NMKKIENCNYAVELGKNKAKFSLVGIAGQDLNEGNSTLTLALVWQLMRRYTLNV-LSDLG 512
              ++EN + A+E   ++    LV I  + + +GN  L L L+W L+  Y++++ + D  
Sbjct: 103 ---QLENVSVALEF-LDRESIKLVSIDSKAIVDGNLKLILGLIWTLILHYSISMPMWDEE 158

Query: 513 EGEKVNDEI----IIKWVNQTL 530
           E E+   +     ++ W+   L
Sbjct: 159 EDEEAKKQTPKQRLLGWIQNKL 180


>gi|67782321 spectrin beta isoform a [Homo sapiens]
          Length = 2328

 Score = 60.8 bits (146), Expect = 4e-09
 Identities = 57/239 (23%), Positives = 96/239 (40%), Gaps = 34/239 (14%)

Query: 124 EKVAFVNWINKALENDPDCKHLIPMNPNDDSLFKSLADGILLCKMINLSEPDTIDERAIN 183
           +K  F  W+N          HL  ++     L+K L DG +L K++ +   + + +    
Sbjct: 56  QKKTFTKWVNS---------HLARVSCRITDLYKDLRDGRMLIKLLEVLSGEMLPKPTKG 106

Query: 184 KKKLTPFTISENLNLALNSASAIGCTVVNIGASDLKEGKPHLVLGLLWQIIKVGLFADIE 243
           K ++      EN++ AL         + N+G+ D+ +G   LVLGL+W II      DI 
Sbjct: 107 KMRIHCL---ENVDKALQFLKEQRVHLENMGSHDIVDGNHRLVLGLIWTIILRFQIQDI- 162

Query: 244 ISRNEALIALLNEGEELEELMKLSPEELLLRWVNYHLTNAGWHTISNFSQDIKDSRAYFH 303
                  +    EG E       S ++ LL W            ++NF+   KD  A+  
Sbjct: 163 -------VVQTQEGRETR-----SAKDALLLWCQMKTAGYPHVNVTNFTSSWKDGLAFNA 210

Query: 304 LLNQIAPKGGEDGPAIAIDLSGINETNDLKRAGLMLQEADK-LGCKQFVTPADVVSGNP 361
           L+++  P          ID   + ++N           A++ LG    + P DV + NP
Sbjct: 211 LIHKHRPD--------LIDFDKLKDSNARHNLEHAFNVAERQLGIIPLLDPEDVFTENP 261



 Score = 53.5 bits (127), Expect = 6e-07
 Identities = 56/233 (24%), Positives = 104/233 (44%), Gaps = 36/233 (15%)

Query: 392 EGESKEERTFRNWMNS--LGVNPYINHLYSDLADALVIFQLYEMIRVPVNWSHVNKPPYP 449
           E E  +++TF  W+NS    V+  I  LY DL D  ++ +L E++   +        P P
Sbjct: 51  EREVVQKKTFTKWVNSHLARVSCRITDLYKDLRDGRMLIKLLEVLSGEML-------PKP 103

Query: 450 ALGG-NMKKIENCNYAVELGKNKAKFSLVGIAGQDLNEGNSTLTLALVWQLMRRYTL-NV 507
             G   +  +EN + A++  K + +  L  +   D+ +GN  L L L+W ++ R+ + ++
Sbjct: 104 TKGKMRIHCLENVDKALQFLKEQ-RVHLENMGSHDIVDGNHRLVLGLIWTIILRFQIQDI 162

Query: 508 LSDLGEGEKVND--EIIIKWVNQTLKS---ANKKTSISSFKDKSISTSLPVLDLIDAIAP 562
           +    EG +     + ++ W           N     SS+K              D +A 
Sbjct: 163 VVQTQEGRETRSAKDALLLWCQMKTAGYPHVNVTNFTSSWK--------------DGLAF 208

Query: 563 NAV----RQEMIRRENLSDEDKLNNAKYAISVA-RKIGARIYALPDDLVEVKP 610
           NA+    R ++I  + L D +  +N ++A +VA R++G      P+D+    P
Sbjct: 209 NALIHKHRPDLIDFDKLKDSNARHNLEHAFNVAERQLGIIPLLDPEDVFTENP 261


>gi|67782319 spectrin beta isoform b [Homo sapiens]
          Length = 2137

 Score = 60.8 bits (146), Expect = 4e-09
 Identities = 57/239 (23%), Positives = 96/239 (40%), Gaps = 34/239 (14%)

Query: 124 EKVAFVNWINKALENDPDCKHLIPMNPNDDSLFKSLADGILLCKMINLSEPDTIDERAIN 183
           +K  F  W+N          HL  ++     L+K L DG +L K++ +   + + +    
Sbjct: 56  QKKTFTKWVNS---------HLARVSCRITDLYKDLRDGRMLIKLLEVLSGEMLPKPTKG 106

Query: 184 KKKLTPFTISENLNLALNSASAIGCTVVNIGASDLKEGKPHLVLGLLWQIIKVGLFADIE 243
           K ++      EN++ AL         + N+G+ D+ +G   LVLGL+W II      DI 
Sbjct: 107 KMRIHCL---ENVDKALQFLKEQRVHLENMGSHDIVDGNHRLVLGLIWTIILRFQIQDI- 162

Query: 244 ISRNEALIALLNEGEELEELMKLSPEELLLRWVNYHLTNAGWHTISNFSQDIKDSRAYFH 303
                  +    EG E       S ++ LL W            ++NF+   KD  A+  
Sbjct: 163 -------VVQTQEGRETR-----SAKDALLLWCQMKTAGYPHVNVTNFTSSWKDGLAFNA 210

Query: 304 LLNQIAPKGGEDGPAIAIDLSGINETNDLKRAGLMLQEADK-LGCKQFVTPADVVSGNP 361
           L+++  P          ID   + ++N           A++ LG    + P DV + NP
Sbjct: 211 LIHKHRPD--------LIDFDKLKDSNARHNLEHAFNVAERQLGIIPLLDPEDVFTENP 261



 Score = 53.5 bits (127), Expect = 6e-07
 Identities = 56/233 (24%), Positives = 104/233 (44%), Gaps = 36/233 (15%)

Query: 392 EGESKEERTFRNWMNS--LGVNPYINHLYSDLADALVIFQLYEMIRVPVNWSHVNKPPYP 449
           E E  +++TF  W+NS    V+  I  LY DL D  ++ +L E++   +        P P
Sbjct: 51  EREVVQKKTFTKWVNSHLARVSCRITDLYKDLRDGRMLIKLLEVLSGEML-------PKP 103

Query: 450 ALGG-NMKKIENCNYAVELGKNKAKFSLVGIAGQDLNEGNSTLTLALVWQLMRRYTL-NV 507
             G   +  +EN + A++  K + +  L  +   D+ +GN  L L L+W ++ R+ + ++
Sbjct: 104 TKGKMRIHCLENVDKALQFLKEQ-RVHLENMGSHDIVDGNHRLVLGLIWTIILRFQIQDI 162

Query: 508 LSDLGEGEKVND--EIIIKWVNQTLKS---ANKKTSISSFKDKSISTSLPVLDLIDAIAP 562
           +    EG +     + ++ W           N     SS+K              D +A 
Sbjct: 163 VVQTQEGRETRSAKDALLLWCQMKTAGYPHVNVTNFTSSWK--------------DGLAF 208

Query: 563 NAV----RQEMIRRENLSDEDKLNNAKYAISVA-RKIGARIYALPDDLVEVKP 610
           NA+    R ++I  + L D +  +N ++A +VA R++G      P+D+    P
Sbjct: 209 NALIHKHRPDLIDFDKLKDSNARHNLEHAFNVAERQLGIIPLLDPEDVFTENP 261


>gi|154277116 spectrin repeat containing, nuclear envelope 1 isoform
           1 [Homo sapiens]
          Length = 8797

 Score = 60.1 bits (144), Expect = 6e-09
 Identities = 65/286 (22%), Positives = 120/286 (41%), Gaps = 48/286 (16%)

Query: 124 EKVAFVNWINKALENDPDCKHLIPMNPNDDSLFKSLADGILLCKMINLSEPDTID-ERAI 182
           +K  F  WIN  L      K   PM  +D  LF+ + DG+ L  ++ +     +  E+  
Sbjct: 29  QKRTFTKWINSHL-----AKRKPPMVVDD--LFEDMKDGVKLLALLEVLSGQKLPCEQGR 81

Query: 183 NKKKLTPFTISENLNLALNSASAIGCTVVNIGASDLKEGKPHLVLGLLWQIIKVGLFADI 242
             K++       N+  AL         +VNI ++D+ +G+P +VLGL+W II   L+  I
Sbjct: 82  RMKRIHAVA---NIGTALKFLEGRKIKLVNINSTDIADGRPSIVLGLMWTII---LYFQI 135

Query: 243 E--ISRNEALIALLNEGEELEELMKL-----------------SPEELLLRWVNYHLTNA 283
           E   S    L +L +    ++ ++                   + ++ LL+WV Y     
Sbjct: 136 EELTSNLPQLQSLSSSASSVDSIVSSETPSPPSKRKVTTKIQGNAKKALLKWVQYTAGKQ 195

Query: 284 GWHTISNFSQDIKDSRAYFHLLNQIAPKGGEDGPAIAIDL---SGINETNDLKRAGLMLQ 340
               + +F +  +   A+  +++ I P+         +DL    G +   +L+ A  + +
Sbjct: 196 TGIEVKDFGKSWRSGVAFHSVIHAIRPE--------LVDLETVKGRSNRENLEDAFTIAE 247

Query: 341 EADKLGCKQFVTPADVVSGNP--KLNLAFVANLFNTYPCLHKPNNN 384
              +LG  + + P DV    P  K  + +VA     YP +H  + +
Sbjct: 248 --TELGIPRLLDPEDVDVDKPDEKSIMTYVAQFLKHYPDIHNASTD 291



 Score = 43.1 bits (100), Expect = 8e-04
 Identities = 68/277 (24%), Positives = 109/277 (39%), Gaps = 74/277 (26%)

Query: 392 EGESKEERTFRNWMNSLGVN----PYINHLYSDLADALVIFQLYEMI---RVPVNWSHVN 444
           E E  ++RTF  W+NS          ++ L+ D+ D + +  L E++   ++P       
Sbjct: 24  EQEIVQKRTFTKWINSHLAKRKPPMVVDDLFEDMKDGVKLLALLEVLSGQKLPCE----- 78

Query: 445 KPPYPALGGNMKKIE---NCNYAVELGKNKAKFSLVGIAGQDLNEGNSTLTLALVWQLMR 501
                  G  MK+I    N   A++  + + K  LV I   D+ +G  ++ L L+W ++ 
Sbjct: 79  ------QGRRMKRIHAVANIGTALKFLEGR-KIKLVNINSTDIADGRPSIVLGLMWTIIL 131

Query: 502 RY-------TLNVLSDLGEGEKVNDEII-------------------------IKWVNQT 529
            +        L  L  L       D I+                         +KWV  T
Sbjct: 132 YFQIEELTSNLPQLQSLSSSASSVDSIVSSETPSPPSKRKVTTKIQGNAKKALLKWVQYT 191

Query: 530 LKSANKKTSISSFKD--KSISTSLPVLDLIDAIAPNAVRQEMIR----RENLSDEDKLNN 583
              A K+T I   KD  KS  + +    +I AI P  V  E ++    RENL  ED    
Sbjct: 192 ---AGKQTGI-EVKDFGKSWRSGVAFHSVIHAIRPELVDLETVKGRSNRENL--EDAFTI 245

Query: 584 AKYAISVARKIGARIYALPDDLVEVKP--KMVMTVFA 618
           A+  + + R +       P+D+   KP  K +MT  A
Sbjct: 246 AETELGIPRLLD------PEDVDVDKPDEKSIMTYVA 276


>gi|12025678 actinin, alpha 4 [Homo sapiens]
          Length = 911

 Score = 57.0 bits (136), Expect = 5e-08
 Identities = 56/220 (25%), Positives = 96/220 (43%), Gaps = 32/220 (14%)

Query: 384 NDIDMNLL---EGESKEERTFRNWMNS--LGVNPYINHLYSDLADALVIFQLYEMIRVPV 438
           +D D +LL     E ++ +TF  W NS        I ++  D  D L +  L E+I    
Sbjct: 36  DDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIDEDFRDGLKLMLLLEVISG-- 93

Query: 439 NWSHVNKPPYPALGG-NMKKIENCNYAVELGKNKAKFSLVGIAGQDLNEGNSTLTLALVW 497
                 + P P  G   + KI N N A++   +K    LV I  +++ +GN+ +TL ++W
Sbjct: 94  -----ERLPKPERGKMRVHKINNVNKALDFIASKG-VKLVSIGAEEIVDGNAKMTLGMIW 147

Query: 498 QLMRRYTLNVLSDLGEGEKVNDEIIIKWVNQTLKSANKKTSISSFKDKSISTSLPVLDLI 557
            ++ R+    + D+   E    E ++ W  Q   +  K  ++ +F           +   
Sbjct: 148 TIILRF---AIQDISVEETSAKEGLLLWC-QRKTAPYKNVNVQNFH----------ISWK 193

Query: 558 DAIAPNAV----RQEMIRRENLSDEDKLNNAKYAISVARK 593
           D +A NA+    R E+I  + L  +D + N   A  VA K
Sbjct: 194 DGLAFNALIHRHRPELIEYDKLRKDDPVTNLNNAFEVAEK 233



 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 63/346 (18%), Positives = 129/346 (37%), Gaps = 62/346 (17%)

Query: 119 SYSEEEKVAFVNWINKALENDPDCKHLIPMNPNDDSLFKSLADGILLCKMINLSEPDTID 178
           ++ ++++  F  W N          HL       +++ +   DG+ L  ++ +   + + 
Sbjct: 47  AWEKQQRKTFTAWCNS---------HLRKAGTQIENIDEDFRDGLKLMLLLEVISGERLP 97

Query: 179 ERAINKKKLTPFTISENLNLALNSASAIGCTVVNIGASDLKEGKPHLVLGLLWQIIKVGL 238
           +    K ++       N+N AL+  ++ G  +V+IGA ++ +G   + LG++W II    
Sbjct: 98  KPERGKMRVHKIN---NVNKALDFIASKGVKLVSIGAEEIVDGNAKMTLGMIWTIILRFA 154

Query: 239 FADIEISRNEALIALLNEGEELEELMKLSPEELLLRWVNYHLTNAGWHTISNFSQDIKDS 298
             DI +    A                   +E LL W            + NF    KD 
Sbjct: 155 IQDISVEETSA-------------------KEGLLLWCQRKTAPYKNVNVQNFHISWKDG 195

Query: 299 RAYFHLLNQIAPKGGEDGPAIAIDLSGINETNDLKRAGLMLQEADK-LGCKQFVTPADVV 357
            A+  L+++  P+         I+   + + + +       + A+K L   + +   D+V
Sbjct: 196 LAFNALIHRHRPE--------LIEYDKLRKDDPVTNLNNAFEVAEKYLDIPKMLDAEDIV 247

Query: 358 S---GNPKLNLAFVANLFNTYPCLHKPNNNDIDMNLLEGESKEERTFRNWMNSLGVNPYI 414
           +    + K  + +V++ ++ +                 G  K E         L VN   
Sbjct: 248 NTARPDEKAIMTYVSSFYHAF----------------SGAQKAETAANRICKVLAVNQEN 291

Query: 415 NHLYSDLADALVIFQLYEMIRVPVNWSHVNKPPYPALGGNMKKIEN 460
            HL  D     +   L E IR  + W   ++ P   +    +K+E+
Sbjct: 292 EHLMEDYEK--LASDLLEWIRRTIPWLE-DRVPQKTIQEMQQKLED 334


>gi|188595687 gamma filamin isoform b [Homo sapiens]
          Length = 2692

 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 55/261 (21%), Positives = 110/261 (42%), Gaps = 38/261 (14%)

Query: 107 GTSTISSEGTQHSYSEE------EKVAFVNWINKALENDPDCKHLIPMNPNDDSLFKSLA 160
           G  T     T+   +E+      ++  F  W N+         HL  +      L + L+
Sbjct: 15  GDETDEMPSTEKDLAEDAPWKKIQQNTFTRWCNE---------HLKCVGKRLTDLQRDLS 65

Query: 161 DGILLCKMINLSEPDTIDERAINKKKLTPFTISENLNLALNSASAIGCTVVNIGASDLKE 220
           DG+ L  ++ +     +  +   +       + EN+++AL         +V+I +  + +
Sbjct: 66  DGLRLIALLEVLSQKRMYRKFHPRPNFRQMKL-ENVSVALEFLEREHIKLVSIDSKAIVD 124

Query: 221 GKPHLVLGLLWQIIKVGLFADIEISRNEALIALLNEGEELEELMKLSPEELLLRWVNYHL 280
           G   L+LGL+W +I            + ++   + E E+ E+  K +P++ LL W+   +
Sbjct: 125 GNLKLILGLIWTLI-----------LHYSISMPMWEDEDDEDARKQTPKQRLLGWIQNKV 173

Query: 281 TNAGWHTISNFSQDIKDSRAYFHLLNQIAPKGGEDGPAIAIDLSGINETNDLKRAGLMLQ 340
                  I+NF++D +D +A   L++  A       P +  D    +    ++ A   +Q
Sbjct: 174 PQL---PITNFNRDWQDGKALGALVDNCA-------PGLCPDWEAWDPNQPVENAREAMQ 223

Query: 341 EADK-LGCKQFVTPADVVSGN 360
           +AD  LG  Q + P ++V  N
Sbjct: 224 QADDWLGVPQVIAPEEIVDPN 244



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 29/113 (25%), Positives = 53/113 (46%), Gaps = 7/113 (6%)

Query: 397 EERTFRNWMNS--LGVNPYINHLYSDLADALVIFQLYEMIRVPVNWSHVNKPPYPALGGN 454
           ++ TF  W N     V   +  L  DL+D L +  L E++    +   + +  +P     
Sbjct: 38  QQNTFTRWCNEHLKCVGKRLTDLQRDLSDGLRLIALLEVL----SQKRMYRKFHPRPNFR 93

Query: 455 MKKIENCNYAVELGKNKAKFSLVGIAGQDLNEGNSTLTLALVWQLMRRYTLNV 507
             K+EN + A+E    +    LV I  + + +GN  L L L+W L+  Y++++
Sbjct: 94  QMKLENVSVALEF-LEREHIKLVSIDSKAIVDGNLKLILGLIWTLILHYSISM 145


>gi|116805322 gamma filamin isoform a [Homo sapiens]
          Length = 2725

 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 55/261 (21%), Positives = 110/261 (42%), Gaps = 38/261 (14%)

Query: 107 GTSTISSEGTQHSYSEE------EKVAFVNWINKALENDPDCKHLIPMNPNDDSLFKSLA 160
           G  T     T+   +E+      ++  F  W N+         HL  +      L + L+
Sbjct: 15  GDETDEMPSTEKDLAEDAPWKKIQQNTFTRWCNE---------HLKCVGKRLTDLQRDLS 65

Query: 161 DGILLCKMINLSEPDTIDERAINKKKLTPFTISENLNLALNSASAIGCTVVNIGASDLKE 220
           DG+ L  ++ +     +  +   +       + EN+++AL         +V+I +  + +
Sbjct: 66  DGLRLIALLEVLSQKRMYRKFHPRPNFRQMKL-ENVSVALEFLEREHIKLVSIDSKAIVD 124

Query: 221 GKPHLVLGLLWQIIKVGLFADIEISRNEALIALLNEGEELEELMKLSPEELLLRWVNYHL 280
           G   L+LGL+W +I            + ++   + E E+ E+  K +P++ LL W+   +
Sbjct: 125 GNLKLILGLIWTLI-----------LHYSISMPMWEDEDDEDARKQTPKQRLLGWIQNKV 173

Query: 281 TNAGWHTISNFSQDIKDSRAYFHLLNQIAPKGGEDGPAIAIDLSGINETNDLKRAGLMLQ 340
                  I+NF++D +D +A   L++  A       P +  D    +    ++ A   +Q
Sbjct: 174 PQL---PITNFNRDWQDGKALGALVDNCA-------PGLCPDWEAWDPNQPVENAREAMQ 223

Query: 341 EADK-LGCKQFVTPADVVSGN 360
           +AD  LG  Q + P ++V  N
Sbjct: 224 QADDWLGVPQVIAPEEIVDPN 244



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 29/113 (25%), Positives = 53/113 (46%), Gaps = 7/113 (6%)

Query: 397 EERTFRNWMNS--LGVNPYINHLYSDLADALVIFQLYEMIRVPVNWSHVNKPPYPALGGN 454
           ++ TF  W N     V   +  L  DL+D L +  L E++    +   + +  +P     
Sbjct: 38  QQNTFTRWCNEHLKCVGKRLTDLQRDLSDGLRLIALLEVL----SQKRMYRKFHPRPNFR 93

Query: 455 MKKIENCNYAVELGKNKAKFSLVGIAGQDLNEGNSTLTLALVWQLMRRYTLNV 507
             K+EN + A+E    +    LV I  + + +GN  L L L+W L+  Y++++
Sbjct: 94  QMKLENVSVALEF-LEREHIKLVSIDSKAIVDGNLKLILGLIWTLILHYSISM 145


>gi|115430237 spectrin, beta, non-erythrocytic 4 isoform sigma1
           [Homo sapiens]
          Length = 2564

 Score = 54.3 bits (129), Expect = 3e-07
 Identities = 36/120 (30%), Positives = 62/120 (51%), Gaps = 11/120 (9%)

Query: 392 EGESKEERTFRNWMNS--LGVNPYINHLYSDLADALVIFQLYEMIRVPVNWSHVNKPPYP 449
           E E+ +++TF  W+NS    V  +I  LY DL D  V+ +L E++          + P P
Sbjct: 58  EREAVQKKTFTKWVNSHLARVGCHIGDLYVDLRDGFVLTRLLEVLSG-------EQLPRP 110

Query: 450 ALGG-NMKKIENCNYAVELGKNKAKFSLVGIAGQDLNEGNSTLTLALVWQLMRRYTLNVL 508
             G   +  +EN + A++  K + +  L  +   D+ +GN  LTL LVW ++ R+ + V+
Sbjct: 111 TRGRMRIHSLENVDKALQFLKEQ-RVHLENVGSHDIVDGNHRLTLGLVWTIILRFQIQVI 169



 Score = 50.1 bits (118), Expect = 6e-06
 Identities = 56/257 (21%), Positives = 107/257 (41%), Gaps = 40/257 (15%)

Query: 124 EKVAFVNWINKALENDPDCKHLIPMNPNDDSLFKSLADGILLCKMINLSEPDTIDERAIN 183
           +K  F  W+N          HL  +  +   L+  L DG +L +++ +   + +      
Sbjct: 63  QKKTFTKWVNS---------HLARVGCHIGDLYVDLRDGFVLTRLLEVLSGEQLPRPTRG 113

Query: 184 KKKLTPFTISENLNLALNSASAIGCTVVNIGASDLKEGKPHLVLGLLWQIIKVGLFADIE 243
           + ++      EN++ AL         + N+G+ D+ +G   L LGL+W II   L   I+
Sbjct: 114 RMRIHSL---ENVDKALQFLKEQRVHLENVGSHDIVDGNHRLTLGLVWTII---LRFQIQ 167

Query: 244 ISRNEALIALLNEGEELEELMKLSPEELLLRWVNYHLTNAGWHTISNFSQDIKDSRAYFH 303
           + + E         E+  E    S ++ LL W            I NF+   +D  A+  
Sbjct: 168 VIKIET--------EDNRETR--SAKDALLLWCQMKTAGYPEVNIQNFTTSWRDGLAFNA 217

Query: 304 LLNQIAPKGGEDGPAIAIDLSGINETN---DLKRAGLMLQEADKLGCKQFVTPADVVSGN 360
           L+++  P          +D S + ++N   +L+RA    ++   LG  + + P DV    
Sbjct: 218 LIHRHRPD--------LVDFSKLTKSNANYNLQRAFRTAEQ--HLGLARLLDPEDVNMEA 267

Query: 361 P--KLNLAFVANLFNTY 375
           P  K  + +V + ++ +
Sbjct: 268 PDEKSIITYVVSFYHYF 284


>gi|5032281 dystrophin Dp427c isoform [Homo sapiens]
          Length = 3677

 Score = 53.9 bits (128), Expect = 4e-07
 Identities = 41/147 (27%), Positives = 72/147 (48%), Gaps = 14/147 (9%)

Query: 392 EGESKEERTFRNWMN---SLGVNPYINHLYSDLADALVIFQLYEMIRVPVNWSHVNKPPY 448
           E E  +++TF  W+N   S     +I +L+SDL D   +  L E +          K P 
Sbjct: 4   EREDVQKKTFTKWVNAQFSKFGKQHIENLFSDLQDGRRLLDLLEGLTG-------QKLPK 56

Query: 449 PALGGNMKKIENCNYAVELGKNKAKFSLVGIAGQDLNEGNSTLTLALVWQLMRRYTL-NV 507
                 +  + N N A+ + +N     LV I   D+ +GN  LTL L+W ++  + + NV
Sbjct: 57  EKGSTRVHALNNVNKALRVLQNN-NVDLVNIGSTDIVDGNHKLTLGLIWNIILHWQVKNV 115

Query: 508 LSDLGEG-EKVNDE-IIIKWVNQTLKS 532
           + ++  G ++ N E I++ WV Q+ ++
Sbjct: 116 MKNIMAGLQQTNSEKILLSWVRQSTRN 142



 Score = 50.8 bits (120), Expect = 4e-06
 Identities = 63/260 (24%), Positives = 104/260 (40%), Gaps = 43/260 (16%)

Query: 124 EKVAFVNWINKALENDPDCKHLIPMNPNDDSLFKSLADGILLCKMINLSEPDTIDERAIN 183
           +K  F  W+N         +H+       ++LF  L DG    ++++L E  T  ++   
Sbjct: 9   QKKTFTKWVNAQFSKFGK-QHI-------ENLFSDLQDGR---RLLDLLEGLT-GQKLPK 56

Query: 184 KKKLTPFTISENLNLALNSASAIGCTVVNIGASDLKEGKPHLVLGLLWQIIKVGLFADIE 243
           +K  T      N+N AL         +VNIG++D+ +G   L LGL+W II   L   ++
Sbjct: 57  EKGSTRVHALNNVNKALRVLQNNNVDLVNIGSTDIVDGNHKLTLGLIWNII---LHWQVK 113

Query: 244 ISRNEALIALLNEGEELEELMKLSPEELLLRWVNYHLTNAGWHTISNFSQDIKDSRAYFH 303
                 +            L + + E++LL WV     N     + NF+    D  A   
Sbjct: 114 NVMKNIMAG----------LQQTNSEKILLSWVRQSTRNYPQVNVINFTTSWSDGLALNA 163

Query: 304 LLNQIAPKGGEDGPAIAIDLSGINETNDLKRAGLMLQEA-----DKLGCKQFVTPADVVS 358
           L++   P           DL   N     + A   L+ A      +LG ++ + P DV +
Sbjct: 164 LIHSHRP-----------DLFDWNSVVCQQSATQRLEHAFNIARYQLGIEKLLDPEDVDT 212

Query: 359 GNP--KLNLAFVANLFNTYP 376
             P  K  L ++ +LF   P
Sbjct: 213 TYPDKKSILMYITSLFQVLP 232


>gi|5032287 dystrophin Dp427p1 isoform [Homo sapiens]
          Length = 3681

 Score = 53.9 bits (128), Expect = 4e-07
 Identities = 41/147 (27%), Positives = 72/147 (48%), Gaps = 14/147 (9%)

Query: 392 EGESKEERTFRNWMN---SLGVNPYINHLYSDLADALVIFQLYEMIRVPVNWSHVNKPPY 448
           E E  +++TF  W+N   S     +I +L+SDL D   +  L E +          K P 
Sbjct: 8   EREDVQKKTFTKWVNAQFSKFGKQHIENLFSDLQDGRRLLDLLEGLTG-------QKLPK 60

Query: 449 PALGGNMKKIENCNYAVELGKNKAKFSLVGIAGQDLNEGNSTLTLALVWQLMRRYTL-NV 507
                 +  + N N A+ + +N     LV I   D+ +GN  LTL L+W ++  + + NV
Sbjct: 61  EKGSTRVHALNNVNKALRVLQNN-NVDLVNIGSTDIVDGNHKLTLGLIWNIILHWQVKNV 119

Query: 508 LSDLGEG-EKVNDE-IIIKWVNQTLKS 532
           + ++  G ++ N E I++ WV Q+ ++
Sbjct: 120 MKNIMAGLQQTNSEKILLSWVRQSTRN 146



 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 65/271 (23%), Positives = 108/271 (39%), Gaps = 43/271 (15%)

Query: 113 SEGTQHSYSEEEKVAFVNWINKALENDPDCKHLIPMNPNDDSLFKSLADGILLCKMINLS 172
           SE +     + +K  F  W+N         +H+       ++LF  L DG    ++++L 
Sbjct: 2   SEVSSDEREDVQKKTFTKWVNAQFSKFGK-QHI-------ENLFSDLQDGR---RLLDLL 50

Query: 173 EPDTIDERAINKKKLTPFTISENLNLALNSASAIGCTVVNIGASDLKEGKPHLVLGLLWQ 232
           E  T  ++   +K  T      N+N AL         +VNIG++D+ +G   L LGL+W 
Sbjct: 51  EGLT-GQKLPKEKGSTRVHALNNVNKALRVLQNNNVDLVNIGSTDIVDGNHKLTLGLIWN 109

Query: 233 IIKVGLFADIEISRNEALIALLNEGEELEELMKLSPEELLLRWVNYHLTNAGWHTISNFS 292
           II   L   ++      +            L + + E++LL WV     N     + NF+
Sbjct: 110 II---LHWQVKNVMKNIMAG----------LQQTNSEKILLSWVRQSTRNYPQVNVINFT 156

Query: 293 QDIKDSRAYFHLLNQIAPKGGEDGPAIAIDLSGINETNDLKRAGLMLQEA-----DKLGC 347
               D  A   L++   P           DL   N     + A   L+ A      +LG 
Sbjct: 157 TSWSDGLALNALIHSHRP-----------DLFDWNSVVCQQSATQRLEHAFNIARYQLGI 205

Query: 348 KQFVTPADVVSGNP--KLNLAFVANLFNTYP 376
           ++ + P DV +  P  K  L ++ +LF   P
Sbjct: 206 EKLLDPEDVDTTYPDKKSILMYITSLFQVLP 236


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.315    0.133    0.380 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,605,375
Number of Sequences: 37866
Number of extensions: 968919
Number of successful extensions: 2475
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 114
Number of HSP's successfully gapped in prelim test: 120
Number of HSP's that attempted gapping in prelim test: 1972
Number of HSP's gapped (non-prelim): 456
length of query: 629
length of database: 18,247,518
effective HSP length: 108
effective length of query: 521
effective length of database: 14,157,990
effective search space: 7376312790
effective search space used: 7376312790
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.