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Search of human proteins with 223718074
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|223718074 hydroxysteroid (17-beta) dehydrogenase 1 [Homo
sapiens]
(328 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|223718074 hydroxysteroid (17-beta) dehydrogenase 1 [Homo sapi... 650 0.0
gi|7657478 retinol dehydrogenase 8 (all-trans) [Homo sapiens] 219 3e-57
gi|150247226 retinol dehydrogenase 16 [Homo sapiens] 89 7e-18
gi|44680136 3-hydroxybutyrate dehydrogenase, type 1 precursor [H... 87 2e-17
gi|44680133 3-hydroxybutyrate dehydrogenase, type 1 precursor [H... 87 2e-17
gi|17738292 3-hydroxybutyrate dehydrogenase, type 1 precursor [H... 87 2e-17
gi|22507405 short chain dehydrogenase/reductase family 9C, membe... 84 2e-16
gi|7706318 dehydrogenase/reductase (SDR family) member 7 [Homo s... 81 1e-15
gi|20149619 dehydrogenase/reductase (SDR family) member 7B [Homo... 80 2e-15
gi|119392083 hydroxysteroid (11-beta) dehydrogenase 2 [Homo sapi... 77 2e-14
gi|142976729 estradiol 17-beta-dehydrogenase 11 [Homo sapiens] 77 2e-14
gi|50726952 retinol dehydrogenase 5 (11-cis and 9-cis) [Homo sap... 75 1e-13
gi|32483357 peroxisomal short-chain alcohol dehydrogenase [Homo ... 74 2e-13
gi|19743808 hydroxysteroid (17-beta) dehydrogenase 6 [Homo sapiens] 69 7e-12
gi|157739938 dehydrogenase/reductase (SDR family) member 7C [Hom... 68 1e-11
gi|33667109 dehydrogenase/reductase member 2 isoform 1 [Homo sap... 68 1e-11
gi|5031737 dehydrogenase/reductase member 2 isoform 2 [Homo sapi... 67 2e-11
gi|40548397 NADP-dependent retinol dehydrogenase/reductase [Homo... 67 3e-11
gi|214010158 NADP-dependent retinol dehydrogenase/reductase [Hom... 67 3e-11
gi|214010156 NADP-dependent retinol dehydrogenase/reductase [Hom... 67 3e-11
gi|22758144 NADP-dependent retinol dehydrogenase/reductase [Homo... 67 3e-11
gi|126723191 dehydrogenase/reductase (SDR family) member 4 like ... 67 3e-11
gi|4503817 3-ketodihydrosphingosine reductase precursor [Homo sa... 65 6e-11
gi|210032110 hydroxysteroid (17-beta) dehydrogenase 13 isoform A... 61 1e-09
gi|31542939 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform ... 60 3e-09
gi|40807363 epidermal retinal dehydrogenase 2 [Homo sapiens] 58 1e-08
gi|126723750 dehydrogenase/reductase (SDR family) member 4 like ... 57 2e-08
gi|25282469 retinol dehydrogenase 10 [Homo sapiens] 56 4e-08
gi|10190704 2,4-dienoyl CoA reductase 2 [Homo sapiens] 56 4e-08
gi|210032112 hydroxysteroid (17-beta) dehydrogenase 13 isoform B... 55 7e-08
>gi|223718074 hydroxysteroid (17-beta) dehydrogenase 1 [Homo
sapiens]
Length = 328
Score = 650 bits (1677), Expect = 0.0
Identities = 328/328 (100%), Positives = 328/328 (100%)
Query: 1 MARTVVLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARALACPPGSL 60
MARTVVLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARALACPPGSL
Sbjct: 1 MARTVVLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARALACPPGSL 60
Query: 61 ETLQLDVRDSKSVAAARERVTEGRVDVLVCNAGLGLLGPLEALGEDAVASVLDVNVVGTV 120
ETLQLDVRDSKSVAAARERVTEGRVDVLVCNAGLGLLGPLEALGEDAVASVLDVNVVGTV
Sbjct: 61 ETLQLDVRDSKSVAAARERVTEGRVDVLVCNAGLGLLGPLEALGEDAVASVLDVNVVGTV 120
Query: 121 RMLQAFLPDMKRRGSGRVLVTGSVGGLMGLPFNDVYCASKFALEGLCESLAVLLLPFGVH 180
RMLQAFLPDMKRRGSGRVLVTGSVGGLMGLPFNDVYCASKFALEGLCESLAVLLLPFGVH
Sbjct: 121 RMLQAFLPDMKRRGSGRVLVTGSVGGLMGLPFNDVYCASKFALEGLCESLAVLLLPFGVH 180
Query: 181 LSLIECGPVHTAFMEKVLGSPEEVLDRTDIHTFHRFYQYLAHSKQVFREAAQNPEEVAEV 240
LSLIECGPVHTAFMEKVLGSPEEVLDRTDIHTFHRFYQYLAHSKQVFREAAQNPEEVAEV
Sbjct: 181 LSLIECGPVHTAFMEKVLGSPEEVLDRTDIHTFHRFYQYLAHSKQVFREAAQNPEEVAEV 240
Query: 241 FLTALRAPKPTLRYFTTERFLPLLRMRLDDPSGSNYVTAMHREVFGDVPAKAEAGAEAGG 300
FLTALRAPKPTLRYFTTERFLPLLRMRLDDPSGSNYVTAMHREVFGDVPAKAEAGAEAGG
Sbjct: 241 FLTALRAPKPTLRYFTTERFLPLLRMRLDDPSGSNYVTAMHREVFGDVPAKAEAGAEAGG 300
Query: 301 GAGPGAEDEAGRGAVGDPELGDPPAAPQ 328
GAGPGAEDEAGRGAVGDPELGDPPAAPQ
Sbjct: 301 GAGPGAEDEAGRGAVGDPELGDPPAAPQ 328
>gi|7657478 retinol dehydrogenase 8 (all-trans) [Homo sapiens]
Length = 311
Score = 219 bits (557), Expect = 3e-57
Identities = 134/286 (46%), Positives = 174/286 (60%), Gaps = 5/286 (1%)
Query: 2 ARTVVLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARALACPPGSLE 61
A VLI+GCSSGIGL LAV+LA DP + ++V AT+RDL + L EAA A +L
Sbjct: 4 APRTVLISGCSSGIGLELAVQLAHDPKKRYQVVATMRDLGKKETL-EAAAGEALGQ-TLT 61
Query: 62 TLQLDVRDSKSVAAARERVTEGRVDVLVCNAGLGLLGPLEALGEDAVASVLDVNVVGTVR 121
QLDV +SVA + +G VDVLV NAG+GL+GPLE L A+ +V D N G VR
Sbjct: 62 VAQLDVCSDESVAQCLSCI-QGEVDVLVNNAGMGLVGPLEGLSLAAMQNVFDTNFFGAVR 120
Query: 122 MLQAFLPDMKRRGSGRVLVTGSVGGLMGLPFNDVYCASKFALEGLCESLAVLLLPFGVHL 181
+++A LP MKRR G ++V SV GL G+ FNDVY ASKFALEG ESLA+ LL F + +
Sbjct: 121 LVKAVLPGMKRRRQGHIVVISSVMGLQGVIFNDVYAASKFALEGFFESLAIQLLQFNIFI 180
Query: 182 SLIECGPVHTAFMEKVLGSPEEV-LDRTDIHTFHRFYQ-YLAHSKQVFREAAQNPEEVAE 239
SL+E GPV T F K+L TD T H F YL S+++F QNP++V +
Sbjct: 181 SLVEPGPVVTEFEGKLLAQVSMAEFPGTDPETLHYFRDLYLPASRKLFCSVGQNPQDVVQ 240
Query: 240 VFLTALRAPKPTLRYFTTERFLPLLRMRLDDPSGSNYVTAMHREVF 285
+ + + +P LR T R+ PL ++ D SGS YV HR +F
Sbjct: 241 AIVNVISSTRPPLRRQTNIRYSPLTTLKTVDSSGSLYVRTTHRLLF 286
>gi|150247226 retinol dehydrogenase 16 [Homo sapiens]
Length = 317
Score = 88.6 bits (218), Expect = 7e-18
Identities = 88/261 (33%), Positives = 127/261 (48%), Gaps = 23/261 (8%)
Query: 6 VLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARALACPPGSLETLQL 65
V ITGC SG G LA +L ++ +V A L +G A + LET+ L
Sbjct: 32 VFITGCDSGFGKLLARQL---DARGLRVLAAC--LTEKG----AEQLRGQTSDRLETVTL 82
Query: 66 DVRDSKSVAAARERVTEGRVDV----LVCNAGLGL-LGPLEALGEDAVASVLDVNVVGTV 120
DV ++SVAAA + V E D LV NAG+ L P E L + ++LDVN++G +
Sbjct: 83 DVTKTESVAAAAQWVKECVRDKGLWGLVNNAGISLPTAPNELLTKQDFVTILDVNLLGVI 142
Query: 121 RMLQAFLPDMKRRGSGRVLVTGSVGGLMGLPFNDVYCASKFALEGLCESLAVLLLPFGVH 180
+ + LP + RR GRV+ SV G + L F YC SK+ +E +SL L FGV
Sbjct: 143 DVTLSLLP-LVRRARGRVVNVSSVMGRVSL-FGGGYCISKYGVEAFSDSLRRELSYFGVK 200
Query: 181 LSLIECGPVHTAF--MEKVLGSPEEVLDRTDIHTFHRFYQ-----YLAHSKQVFREAAQN 233
+++IE G TA E+ L S E+ DR+ + + Y ++Q+ ++ Q+
Sbjct: 201 VAMIEPGYFKTAVTSKERFLKSFLEIWDRSSPEVKEAYGEKFVADYKKSAEQMEQKCTQD 260
Query: 234 PEEVAEVFLTALRAPKPTLRY 254
V AL A P RY
Sbjct: 261 LSLVTNCMEHALIACHPRTRY 281
>gi|44680136 3-hydroxybutyrate dehydrogenase, type 1 precursor [Homo
sapiens]
Length = 343
Score = 87.4 bits (215), Expect = 2e-17
Identities = 72/206 (34%), Positives = 101/206 (49%), Gaps = 17/206 (8%)
Query: 6 VLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARAL-ACPPGSLETLQ 64
VL+TGC SG G LA L S + F V+A +K +G + + L + L T+Q
Sbjct: 58 VLVTGCDSGFGFSLAKHLHS---KGFLVFAGCL-MKDKGH--DGVKELDSLNSDRLRTVQ 111
Query: 65 LDVRDSKSVAAARERVTEGRVDV------LVCNAGLGLLGPLEALGEDAVASVLDVNVVG 118
L+V S+ V E V D LV NAG+ G +E + V +VN+ G
Sbjct: 112 LNVCSSEEVEKVVEIVRSSLKDPEKGMWGLVNNAGISTFGEVEFTSLETYKQVAEVNLWG 171
Query: 119 TVRMLQAFLPDMKRRGSGRVLVTGSVGGLMGLPFNDVYCASKFALEGLCESLAVLLLPFG 178
TVRM ++FLP + RR GRV+ S+ G M P YC +KF +E + L + P G
Sbjct: 172 TVRMTKSFLP-LIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMYPLG 230
Query: 179 VHLSLIECGPVHTAFMEKVLGSPEEV 204
V +S++E G A L SPE +
Sbjct: 231 VKVSVVEPGNFIAA---TSLYSPESI 253
>gi|44680133 3-hydroxybutyrate dehydrogenase, type 1 precursor [Homo
sapiens]
Length = 343
Score = 87.4 bits (215), Expect = 2e-17
Identities = 72/206 (34%), Positives = 101/206 (49%), Gaps = 17/206 (8%)
Query: 6 VLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARAL-ACPPGSLETLQ 64
VL+TGC SG G LA L S + F V+A +K +G + + L + L T+Q
Sbjct: 58 VLVTGCDSGFGFSLAKHLHS---KGFLVFAGCL-MKDKGH--DGVKELDSLNSDRLRTVQ 111
Query: 65 LDVRDSKSVAAARERVTEGRVDV------LVCNAGLGLLGPLEALGEDAVASVLDVNVVG 118
L+V S+ V E V D LV NAG+ G +E + V +VN+ G
Sbjct: 112 LNVCSSEEVEKVVEIVRSSLKDPEKGMWGLVNNAGISTFGEVEFTSLETYKQVAEVNLWG 171
Query: 119 TVRMLQAFLPDMKRRGSGRVLVTGSVGGLMGLPFNDVYCASKFALEGLCESLAVLLLPFG 178
TVRM ++FLP + RR GRV+ S+ G M P YC +KF +E + L + P G
Sbjct: 172 TVRMTKSFLP-LIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMYPLG 230
Query: 179 VHLSLIECGPVHTAFMEKVLGSPEEV 204
V +S++E G A L SPE +
Sbjct: 231 VKVSVVEPGNFIAA---TSLYSPESI 253
>gi|17738292 3-hydroxybutyrate dehydrogenase, type 1 precursor [Homo
sapiens]
Length = 343
Score = 87.4 bits (215), Expect = 2e-17
Identities = 72/206 (34%), Positives = 101/206 (49%), Gaps = 17/206 (8%)
Query: 6 VLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARAL-ACPPGSLETLQ 64
VL+TGC SG G LA L S + F V+A +K +G + + L + L T+Q
Sbjct: 58 VLVTGCDSGFGFSLAKHLHS---KGFLVFAGCL-MKDKGH--DGVKELDSLNSDRLRTVQ 111
Query: 65 LDVRDSKSVAAARERVTEGRVDV------LVCNAGLGLLGPLEALGEDAVASVLDVNVVG 118
L+V S+ V E V D LV NAG+ G +E + V +VN+ G
Sbjct: 112 LNVCSSEEVEKVVEIVRSSLKDPEKGMWGLVNNAGISTFGEVEFTSLETYKQVAEVNLWG 171
Query: 119 TVRMLQAFLPDMKRRGSGRVLVTGSVGGLMGLPFNDVYCASKFALEGLCESLAVLLLPFG 178
TVRM ++FLP + RR GRV+ S+ G M P YC +KF +E + L + P G
Sbjct: 172 TVRMTKSFLP-LIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMYPLG 230
Query: 179 VHLSLIECGPVHTAFMEKVLGSPEEV 204
V +S++E G A L SPE +
Sbjct: 231 VKVSVVEPGNFIAA---TSLYSPESI 253
>gi|22507405 short chain dehydrogenase/reductase family 9C, member 7
[Homo sapiens]
Length = 313
Score = 84.0 bits (206), Expect = 2e-16
Identities = 82/267 (30%), Positives = 121/267 (45%), Gaps = 25/267 (9%)
Query: 1 MARTVVLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARALACPPG-S 59
++ V ITGC SG G LA +L Q T E ++ L
Sbjct: 23 LSEKYVFITGCDSGFGNLLAKQLVDRGMQVLAACFTE----------EGSQKLQRDTSYR 72
Query: 60 LETLQLDVRDSKSVAAA----RERVTEGRVDVLVCNAGLGL-LGPLEALGEDAVASVLDV 114
L+T LDV S+S+ AA R++V E + LV NAG+GL GP E L +D V++V
Sbjct: 73 LQTTLLDVTKSESIKAAAQWVRDKVGEQGLWALVNNAGVGLPSGPNEWLTKDDFVKVINV 132
Query: 115 NVVGTVRMLQAFLPDMKRRGSGRVLVTGSVGGLMGLPFNDVYCASKFALEGLCESLAVLL 174
N+VG + + LP M +R GRV+ S GG + + YC SKF +E +S+ L
Sbjct: 133 NLVGLIEVTLHMLP-MVKRARGRVVNMSSSGGRVAV-IGGGYCVSKFGVEAFSDSIRREL 190
Query: 175 LPFGVHLSLIECGPVHTAFM--EKVLGSPEEVLDR-----TDIHTFHRFYQYLAHSKQVF 227
FGV + +IE G TA + E + ++ +R D + F Y K +
Sbjct: 191 YYFGVKVCIIEPGNYRTAILGKENLESRMRKLWERLPQETRDSYGEDYFRIYTDKLKNIM 250
Query: 228 REAAQNPEEVAEVFLTALRAPKPTLRY 254
+ A +V A+ + P +RY
Sbjct: 251 QVAEPRVRDVINSMEHAIVSRSPRIRY 277
>gi|7706318 dehydrogenase/reductase (SDR family) member 7 [Homo
sapiens]
Length = 339
Score = 81.3 bits (199), Expect = 1e-15
Identities = 63/202 (31%), Positives = 99/202 (49%), Gaps = 15/202 (7%)
Query: 5 VVLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARALACPPGSLE--- 61
VV +TG SSGIG LA +L+ K+ +L + E + G+L+
Sbjct: 52 VVWVTGASSGIGEELAYQLS-------KLGVSLVLSARRVHELERVKRRCLENGNLKEKD 104
Query: 62 --TLQLDVRDSKSVAAARERVTE--GRVDVLVCNAGLGLLGPLEALGEDAVASVLDVNVV 117
L LD+ D+ S AA + V + GR+D+LV N G+ D ++++N +
Sbjct: 105 ILVLPLDLTDTGSHEAATKAVLQEFGRIDILVNNGGMSQRSLCMDTSLDVYRKLIELNYL 164
Query: 118 GTVRMLQAFLPDMKRRGSGRVLVTGSVGGLMGLPFNDVYCASKFALEGLCESLAVLLLPF 177
GTV + + LP M R G+++ S+ G++ +P + YCASK AL G L L +
Sbjct: 165 GTVSLTKCVLPHMIERKQGKIVTVNSILGIISVPLSIGYCASKHALRGFFNGLRTELATY 224
Query: 178 -GVHLSLIECGPVHTAFMEKVL 198
G+ +S I GPV + +E L
Sbjct: 225 PGIIVSNICPGPVQSNIVENSL 246
>gi|20149619 dehydrogenase/reductase (SDR family) member 7B [Homo
sapiens]
Length = 325
Score = 80.1 bits (196), Expect = 2e-15
Identities = 58/213 (27%), Positives = 96/213 (45%), Gaps = 5/213 (2%)
Query: 1 MARTVVLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARALACPPGSL 60
+ VV+ITG +SG+G A + ++ L+ R A+ A
Sbjct: 50 LRNAVVVITGATSGLGKECAKVFYAAGAKLVLCGRNGGALEELIRELTASHATKVQTHKP 109
Query: 61 ETLQLDVRDSKSVAAARERVTE--GRVDVLVCNAGLGLLGPLEALGEDAVASVLDVNVVG 118
+ D+ DS ++ AA + + G VD+LV NAG+ G + D V++ N G
Sbjct: 110 YLVTFDLTDSGAIVAAAAEILQCFGYVDILVNNAGISYRGTIMDTTVDVDKRVMETNYFG 169
Query: 119 TVRMLQAFLPDMKRRGSGRVLVTGSVGGLMGLPFNDVYCASKFALEGLCESLAVLLLPFG 178
V + +A LP M +R G ++ S+ G M +PF Y ASK A + + L + +
Sbjct: 170 PVALTKALLPSMIKRRQGHIVAISSIQGKMSIPFRSAYAASKHATQAFFDCLRAEMEQYE 229
Query: 179 VHLSLIECGPVHTAFMEKVL---GSPEEVLDRT 208
+ +++I G +HT + GS V+D T
Sbjct: 230 IEVTVISPGYIHTNLSVNAITADGSRYGVMDTT 262
>gi|119392083 hydroxysteroid (11-beta) dehydrogenase 2 [Homo
sapiens]
Length = 405
Score = 77.0 bits (188), Expect = 2e-14
Identities = 76/271 (28%), Positives = 112/271 (41%), Gaps = 27/271 (9%)
Query: 1 MARTVVLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARALACPPGSL 60
+A VLITGC SG G A +L S F V AT+ +L + G A C L
Sbjct: 80 VATRAVLITGCDSGFGKETAKKL---DSMGFTVLATVLELNSPG----AIELRTCCSPRL 132
Query: 61 ETLQLDVRDSKSVAAARE----RVTEGRVDVLVCNAGLG-LLGPLEALGEDAVASVLDVN 115
LQ+D+ ++ E T + LV NAG ++ E S ++VN
Sbjct: 133 RLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVN 192
Query: 116 VVGTVRMLQAFLPDMKRRGSGRVLVTGSVGGLMGLPFNDVYCASKFALEGLCESLAVLLL 175
G + + + LP + R GR++ GS G M P Y SK A+ L ++ + LL
Sbjct: 193 FFGALELTKGLLP-LLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELL 251
Query: 176 PFGVHLSLIECGPVHTAFMEKV-----------LGSPEEVLDRTDIHTFHRFYQYLAHSK 224
P+GV +S+I+ G T + V P+E+L + HS
Sbjct: 252 PWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHS- 310
Query: 225 QVFREAAQNPEEVAEVFLTALRAPKPTLRYF 255
R A + V + AL A +P RY+
Sbjct: 311 --LRLAMSDLTPVVDAITDALLAARPRRRYY 339
>gi|142976729 estradiol 17-beta-dehydrogenase 11 [Homo sapiens]
Length = 300
Score = 77.0 bits (188), Expect = 2e-14
Identities = 79/276 (28%), Positives = 120/276 (43%), Gaps = 40/276 (14%)
Query: 5 VVLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARALACPPGSLETLQ 64
+VLITG GIG RL + K L D+ G L E A + T
Sbjct: 38 IVLITGAGHGIG-----RLTAYEFAKLKSKLVLWDINKHG-LEETAAKCKGLGAKVHTFV 91
Query: 65 LDVRDSKSVAAARERVTE--GRVDVLVCNAGLGLLGPLEALGEDAVASVLDVNVVGTVRM 122
+D + + + ++ ++V G V +LV NAG+ L A + + +VNV+
Sbjct: 92 VDCSNREDIYSSAKKVKAEIGDVSILVNNAGVVYTSDLFATQDPQIEKTFEVNVLAHFWT 151
Query: 123 LQAFLPDMKRRGSGRVLVTGSVGGLMGLPFNDVYCASKFALEG----LCESLAVLLLPFG 178
+AFLP M + G ++ S G + +PF YC+SKFA G L + LA L + G
Sbjct: 152 TKAFLPAMTKNNHGHIVTVASAAGHVSVPFLLAYCSSKFAAVGFHKTLTDELAALQIT-G 210
Query: 179 VHLSLIECGPVHTAFMEKVLGS------PEEVLDRTDIHTFHRFYQYLAHSKQVFREAAQ 232
V + + V+T F++ S PEEV++R + L K +F
Sbjct: 211 VKTTCLCPNFVNTGFIKNPSTSLGPTLEPEEVVNRL-------MHGILTEQKMIF----- 258
Query: 233 NPEEVAEVFLTALRAPKPTLRYFTTERFLPLLRMRL 268
P +A FLT TL ERFL +L+ ++
Sbjct: 259 IPSSIA--FLT-------TLERILPERFLAVLKQKI 285
>gi|50726952 retinol dehydrogenase 5 (11-cis and 9-cis) [Homo
sapiens]
Length = 318
Score = 74.7 bits (182), Expect = 1e-13
Identities = 64/187 (34%), Positives = 92/187 (49%), Gaps = 16/187 (8%)
Query: 6 VLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARALACPPGSLETLQL 65
V ITGC SG G LA++L + F+V A+ L A + L T L
Sbjct: 31 VFITGCDSGFGRLLALQL---DQRGFRVLASCLTPSGAEDLQRVASS------RLHTTLL 81
Query: 66 DVRDSKSVAAARE----RVTEGRVDVLVCNAGL-GLLGPLEALGEDAVASVLDVNVVGTV 120
D+ D +SV A + V E + LV NAG+ G++GP L D VL+VN +G +
Sbjct: 82 DITDPQSVQQAAKWVEMHVKEAGLFGLVNNAGVAGIIGPTPWLTRDDFQRVLNVNTMGPI 141
Query: 121 RMLQAFLPDMKRRGSGRVLVTGSVGGLMGLPFNDVYCASKFALEGLCESLAVLLLPFGVH 180
+ A LP + ++ GRV+ SV G + YC SKF LE +SL + FG+
Sbjct: 142 GVTLALLP-LLQQARGRVINITSVLGRLAANGGG-YCVSKFGLEAFSDSLRRDVAHFGIR 199
Query: 181 LSLIECG 187
+S++E G
Sbjct: 200 VSIVEPG 206
>gi|32483357 peroxisomal short-chain alcohol dehydrogenase [Homo
sapiens]
Length = 278
Score = 73.9 bits (180), Expect = 2e-13
Identities = 56/201 (27%), Positives = 94/201 (46%), Gaps = 19/201 (9%)
Query: 1 MARTVVLITGCSSGIGLHLAVRLASDPS-------QSFKVYATLRDLKTQGRLWEAARAL 53
+A V L+T + GIG +A RLA D + + V + L+ +G +
Sbjct: 30 LANKVALVTASTDGIGFAIARRLAQDGAHVVVSSRKQQNVDQAVATLQGEGL---SVTGT 86
Query: 54 ACPPGSLETLQLDVRDSKSVAAARERVTEGRVDVLVCNAGLG-LLGPLEALGEDAVASVL 112
C G E D + + A ++ G +D+LV NA + G + + E+ L
Sbjct: 87 VCHVGKAE-------DRERLVATAVKL-HGGIDILVSNAAVNPFFGSIMDVTEEVWDKTL 138
Query: 113 DVNVVGTVRMLQAFLPDMKRRGSGRVLVTGSVGGLMGLPFNDVYCASKFALEGLCESLAV 172
D+NV M +A +P+M++RG G V++ S+ P Y SK AL GL ++LA+
Sbjct: 139 DINVKAPALMTKAVVPEMEKRGGGSVVIVSSIAAFSPSPGFSPYNVSKTALLGLTKTLAI 198
Query: 173 LLLPFGVHLSLIECGPVHTAF 193
L P + ++ + G + T+F
Sbjct: 199 ELAPRNIRVNCLAPGLIKTSF 219
>gi|19743808 hydroxysteroid (17-beta) dehydrogenase 6 [Homo sapiens]
Length = 317
Score = 68.6 bits (166), Expect = 7e-12
Identities = 77/266 (28%), Positives = 121/266 (45%), Gaps = 33/266 (12%)
Query: 6 VLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARALACPPGSLETLQL 65
V ITGC SG G LA +L ++ +V A L +G A + LET+ L
Sbjct: 32 VFITGCDSGFGNLLARQL---DARGLRVLAAC--LTEKG----AEQLRGQTSDRLETVTL 82
Query: 66 DVRDSKSVAAARERVTEGRVDV----LVCNAGLGLLGPL---EALGEDAVASVLDVNVVG 118
DV +S+AAA + V E D LV NAG+ L P+ E L + ++L VN++G
Sbjct: 83 DVTKMESIAAATQWVKEHVGDRGLWGLVNNAGI--LTPITLCEWLNTEDSMNMLKVNLIG 140
Query: 119 TVRMLQAFLPDMKRRGSGRVLVTGSVGGLMGLPFNDVYCASKFALEGLCESLAVLLLPFG 178
+++ + LP + RR GR++ S+ G + F YC SK+ +E + L + FG
Sbjct: 141 VIQVTLSMLP-LVRRARGRIVNVSSILGRVAF-FVGGYCVSKYGVEAFSDILRREIQHFG 198
Query: 179 VHLSLIECGPVHTAF------MEKVLGS----PEEVLDRTDIHTFHRFYQYLAHSKQVFR 228
V +S++E G T +E++ S P+ + + F Y + K+
Sbjct: 199 VKISIVEPGYFRTGMTNMTQSLERMKQSWKEAPKHIKETYGQQYFDALYNIM---KEGLL 255
Query: 229 EAAQNPEEVAEVFLTALRAPKPTLRY 254
+ N V + AL + P RY
Sbjct: 256 NCSTNLNLVTDCMEHALTSVHPRTRY 281
>gi|157739938 dehydrogenase/reductase (SDR family) member 7C [Homo
sapiens]
Length = 311
Score = 68.2 bits (165), Expect = 1e-11
Identities = 62/249 (24%), Positives = 113/249 (45%), Gaps = 22/249 (8%)
Query: 5 VVLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARALACPPGSL--ET 62
VV+IT SG+G A + + ++ ++ + L++A ++A P + +
Sbjct: 39 VVVITDAISGLGKECARVFHTGGA---RLVLCGKNWERLENLYDALISVADPSKTFTPKL 95
Query: 63 LQLDVRDSKSVAAARERVTE--GRVDVLVCNAGLGLLGPLEALGEDAVASVLDVNVVGTV 120
+ LD+ D V + V + G VD+L+ NA + + GP + + ++D N G +
Sbjct: 96 VLLDLSDISCVPDVAKEVLDCYGCVDILINNASVKVKGPAHKISLELDKKIMDANYFGPI 155
Query: 121 RMLQAFLPDMKRRGSGRVLVTGSVGGLMGLPFNDVYCASKFALEGLCESLAVLLLPFGVH 180
+ +A LP+M R +G++++ ++ G G+PF Y ASK A G + L + + V
Sbjct: 156 TLTKALLPNMISRRTGQIVLVNNIQGKFGIPFRTTYAASKHAALGFFDCLRAEVEEYDVV 215
Query: 181 LSLIECGPVHTAFMEKVLGSPEEVLDRTDIHTFHRFYQYLAHSKQVFREAAQNPEEVAEV 240
+S V F+ PE+ I F F++ L + +P EVAE
Sbjct: 216 IS-----TVSPTFIRSYHVYPEQGNWEASIWKF--FFRKLTY--------GVHPVEVAEE 260
Query: 241 FLTALRAPK 249
+ +R K
Sbjct: 261 VMRTVRRKK 269
>gi|33667109 dehydrogenase/reductase member 2 isoform 1 [Homo
sapiens]
Length = 300
Score = 67.8 bits (164), Expect = 1e-11
Identities = 66/203 (32%), Positives = 94/203 (46%), Gaps = 16/203 (7%)
Query: 1 MARTVVLITGCSSGIGLHLAVRLASDPS----QSFKVYATLRDL-KTQGRLWEAARALAC 55
+A V ++TG +SGIG +A RLA D + S K R + K QG A + C
Sbjct: 34 LANRVAVVTGSTSGIGFAIARRLARDGAHVVISSRKQQNVDRAMAKLQGEGLSVA-GIVC 92
Query: 56 PPGSLETLQLDVRDSKSVAAARERVTEGRVDVLVCNAGLG-LLGPLEALGEDAVASVLDV 114
G E + + VA A E G VD LVC+AG+ L+G E +L V
Sbjct: 93 HVGKAEDRE------QLVAKALEHC--GGVDFLVCSAGVNPLVGSTLGTSEQIWDKILSV 144
Query: 115 NVVGTVRMLQAFLPDMKRRGSGRVLVTGSVGGLMGLPFNDVYCASKFALEGLCESLAVLL 174
NV +L LP M+ R G V++ S+ + VY SK AL GL +LA+ L
Sbjct: 145 NVKSPALLLSQLLPYMENR-RGAVILVSSIAAYNPVVALGVYNVSKTALLGLTRTLALEL 203
Query: 175 LPFGVHLSLIECGPVHTAFMEKV 197
P + ++ + G + T F + V
Sbjct: 204 APKDIRVNCVVPGIIKTDFSKVV 226
>gi|5031737 dehydrogenase/reductase member 2 isoform 2 [Homo
sapiens]
Length = 280
Score = 67.4 bits (163), Expect = 2e-11
Identities = 66/206 (32%), Positives = 95/206 (46%), Gaps = 16/206 (7%)
Query: 1 MARTVVLITGCSSGIGLHLAVRLASDPS----QSFKVYATLRDL-KTQGRLWEAARALAC 55
+A V ++TG +SGIG +A RLA D + S K R + K QG A + C
Sbjct: 34 LANRVAVVTGSTSGIGFAIARRLARDGAHVVISSRKQQNVDRAMAKLQGEGLSVA-GIVC 92
Query: 56 PPGSLETLQLDVRDSKSVAAARERVTEGRVDVLVCNAGLG-LLGPLEALGEDAVASVLDV 114
G E + + VA A E G VD LVC+AG+ L+G E +L V
Sbjct: 93 HVGKAEDRE------QLVAKALEHC--GGVDFLVCSAGVNPLVGSTLGTSEQIWDKILSV 144
Query: 115 NVVGTVRMLQAFLPDMKRRGSGRVLVTGSVGGLMGLPFNDVYCASKFALEGLCESLAVLL 174
NV +L LP M+ R G V++ S+ + VY SK AL GL +LA+ L
Sbjct: 145 NVKSPALLLSQLLPYMENR-RGAVILVSSIAAYNPVVALGVYNVSKTALLGLTRTLALEL 203
Query: 175 LPFGVHLSLIECGPVHTAFMEKVLGS 200
P + ++ + G + T F + G+
Sbjct: 204 APKDIRVNCVVPGIIKTDFSKVFHGN 229
>gi|40548397 NADP-dependent retinol dehydrogenase/reductase [Homo
sapiens]
Length = 319
Score = 66.6 bits (161), Expect = 3e-11
Identities = 62/197 (31%), Positives = 95/197 (48%), Gaps = 16/197 (8%)
Query: 6 VLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARALACPPGSLETLQL 65
+ ITGC SG G +LA R D + A L + + E + L T+ L
Sbjct: 32 IFITGCDSGFG-NLAAR-TFDKKGFHVIAACLTESGSTALKAETSERL-------RTVLL 82
Query: 66 DVRDSKSVAAA----RERVTEGRVDVLVCNAGL-GLLGPLEALGEDAVASVLDVNVVGTV 120
DV D ++V + +V E + L+ NAG+ G+L P + L + ++VN+ G +
Sbjct: 83 DVTDPENVKRTAQWVKNQVGEKGLWGLINNAGVPGVLAPTDWLTLEDYREPIEVNLFGLI 142
Query: 121 RMLQAFLPDMKRRGSGRVLVTGSVGGLMGLPFNDVYCASKFALEGLCESLAVLLLPFGVH 180
+ LP +K+ GRV+ SVGG + + Y SK+A+EG +SL + FGVH
Sbjct: 143 SVTLNMLPLVKK-AQGRVINVSSVGGRLAI-VGGGYTPSKYAVEGFNDSLRRDMKAFGVH 200
Query: 181 LSLIECGPVHTAFMEKV 197
+S IE G T + V
Sbjct: 201 VSCIEPGLFKTNLADPV 217
>gi|214010158 NADP-dependent retinol dehydrogenase/reductase [Homo
sapiens]
Length = 319
Score = 66.6 bits (161), Expect = 3e-11
Identities = 62/197 (31%), Positives = 95/197 (48%), Gaps = 16/197 (8%)
Query: 6 VLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARALACPPGSLETLQL 65
+ ITGC SG G +LA R D + A L + + E + L T+ L
Sbjct: 32 IFITGCDSGFG-NLAAR-TFDKKGFHVIAACLTESGSTALKAETSERL-------RTVLL 82
Query: 66 DVRDSKSVAAA----RERVTEGRVDVLVCNAGL-GLLGPLEALGEDAVASVLDVNVVGTV 120
DV D ++V + +V E + L+ NAG+ G+L P + L + ++VN+ G +
Sbjct: 83 DVTDPENVKRTAQWVKNQVGEKGLWGLINNAGVPGVLAPTDWLTLEDYREPIEVNLFGLI 142
Query: 121 RMLQAFLPDMKRRGSGRVLVTGSVGGLMGLPFNDVYCASKFALEGLCESLAVLLLPFGVH 180
+ LP +K+ GRV+ SVGG + + Y SK+A+EG +SL + FGVH
Sbjct: 143 SVTLNMLPLVKK-AQGRVINVSSVGGRLAI-VGGGYTPSKYAVEGFNDSLRRDMKAFGVH 200
Query: 181 LSLIECGPVHTAFMEKV 197
+S IE G T + V
Sbjct: 201 VSCIEPGLFKTNLADPV 217
>gi|214010156 NADP-dependent retinol dehydrogenase/reductase [Homo
sapiens]
Length = 319
Score = 66.6 bits (161), Expect = 3e-11
Identities = 62/197 (31%), Positives = 95/197 (48%), Gaps = 16/197 (8%)
Query: 6 VLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARALACPPGSLETLQL 65
+ ITGC SG G +LA R D + A L + + E + L T+ L
Sbjct: 32 IFITGCDSGFG-NLAAR-TFDKKGFHVIAACLTESGSTALKAETSERL-------RTVLL 82
Query: 66 DVRDSKSVAAA----RERVTEGRVDVLVCNAGL-GLLGPLEALGEDAVASVLDVNVVGTV 120
DV D ++V + +V E + L+ NAG+ G+L P + L + ++VN+ G +
Sbjct: 83 DVTDPENVKRTAQWVKNQVGEKGLWGLINNAGVPGVLAPTDWLTLEDYREPIEVNLFGLI 142
Query: 121 RMLQAFLPDMKRRGSGRVLVTGSVGGLMGLPFNDVYCASKFALEGLCESLAVLLLPFGVH 180
+ LP +K+ GRV+ SVGG + + Y SK+A+EG +SL + FGVH
Sbjct: 143 SVTLNMLPLVKK-AQGRVINVSSVGGRLAI-VGGGYTPSKYAVEGFNDSLRRDMKAFGVH 200
Query: 181 LSLIECGPVHTAFMEKV 197
+S IE G T + V
Sbjct: 201 VSCIEPGLFKTNLADPV 217
>gi|22758144 NADP-dependent retinol dehydrogenase/reductase [Homo
sapiens]
Length = 319
Score = 66.6 bits (161), Expect = 3e-11
Identities = 62/197 (31%), Positives = 95/197 (48%), Gaps = 16/197 (8%)
Query: 6 VLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARALACPPGSLETLQL 65
+ ITGC SG G +LA R D + A L + + E + L T+ L
Sbjct: 32 IFITGCDSGFG-NLAAR-TFDKKGFHVIAACLTESGSTALKAETSERL-------RTVLL 82
Query: 66 DVRDSKSVAAA----RERVTEGRVDVLVCNAGL-GLLGPLEALGEDAVASVLDVNVVGTV 120
DV D ++V + +V E + L+ NAG+ G+L P + L + ++VN+ G +
Sbjct: 83 DVTDPENVKRTAQWVKNQVGEKGLWGLINNAGVPGVLAPTDWLTLEDYREPIEVNLFGLI 142
Query: 121 RMLQAFLPDMKRRGSGRVLVTGSVGGLMGLPFNDVYCASKFALEGLCESLAVLLLPFGVH 180
+ LP +K+ GRV+ SVGG + + Y SK+A+EG +SL + FGVH
Sbjct: 143 SVTLNMLPLVKK-AQGRVINVSSVGGRLAI-VGGGYTPSKYAVEGFNDSLRRDMKAFGVH 200
Query: 181 LSLIECGPVHTAFMEKV 197
+S IE G T + V
Sbjct: 201 VSCIEPGLFKTNLADPV 217
>gi|126723191 dehydrogenase/reductase (SDR family) member 4 like 2
[Homo sapiens]
Length = 232
Score = 66.6 bits (161), Expect = 3e-11
Identities = 53/192 (27%), Positives = 87/192 (45%), Gaps = 19/192 (9%)
Query: 1 MARTVVLITGCSSGIGLHLAVRLASDPS-------QSFKVYATLRDLKTQGRLWEAARAL 53
+ V L+T + GIG +A RLA D + + V + L+ +G +
Sbjct: 30 LTNKVALVTASTDGIGFAIARRLAQDRAHVVVSSRKQQNVDQAVATLQGEGL---SVTGT 86
Query: 54 ACPPGSLETLQLDVRDSKSVAAARERVTEGRVDVLVCNAGLG-LLGPLEALGEDAVASVL 112
C G E D + + A ++ G +D+LV NA + G L + E+ L
Sbjct: 87 VCHVGKAE-------DRERLVAMAVKL-HGGIDILVSNAAVNPFFGSLMDVTEEVWDKTL 138
Query: 113 DVNVVGTVRMLQAFLPDMKRRGSGRVLVTGSVGGLMGLPFNDVYCASKFALEGLCESLAV 172
D+NV M +A +P+M++RG G V++ S+ P Y SK AL GL +LA+
Sbjct: 139 DINVKAPALMTKAVVPEMEKRGGGSVVIVSSIAAFSPSPGFSPYNVSKTALLGLNNTLAI 198
Query: 173 LLLPFGVHLSLI 184
L P + ++ +
Sbjct: 199 ELAPRNIRVNCL 210
>gi|4503817 3-ketodihydrosphingosine reductase precursor [Homo
sapiens]
Length = 332
Score = 65.5 bits (158), Expect = 6e-11
Identities = 52/185 (28%), Positives = 93/185 (50%), Gaps = 13/185 (7%)
Query: 6 VLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARALACPPGSLETLQL 65
V++TG SSGIG +A+ + + TL + + +L +A + + + + + L
Sbjct: 35 VVVTGGSSGIGKCIAIECYKQGA-----FITLV-ARNEDKLLQAKKEIEMHSINDKQVVL 88
Query: 66 DV-----RDSKSVAAARERVTE--GRVDVLVCNAGLGLLGPLEALGEDAVASVLDVNVVG 118
+ +D V ++ E G VD+LV AG+ + G E L ++ +N +G
Sbjct: 89 CISVDVSQDYNQVENVIKQAQEKLGPVDMLVNCAGMAVSGKFEDLEVSTFERLMSINYLG 148
Query: 119 TVRMLQAFLPDMKRRGSGRVLVTGSVGGLMGLPFNDVYCASKFALEGLCESLAVLLLPFG 178
+V +A + MK R GR++ S G +GL Y ASKFA+ GL E+L + + P+
Sbjct: 149 SVYPSRAVITTMKERRVGRIVFVSSQAGQLGLFGFTAYSASKFAIRGLAEALQMEVKPYN 208
Query: 179 VHLSL 183
V++++
Sbjct: 209 VYITV 213
>gi|210032110 hydroxysteroid (17-beta) dehydrogenase 13 isoform A
[Homo sapiens]
Length = 300
Score = 61.2 bits (147), Expect = 1e-09
Identities = 49/180 (27%), Positives = 78/180 (43%), Gaps = 8/180 (4%)
Query: 1 MARTVVLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARALACPPGSL 60
+A +VLITG GIG A S L D+ +G + E A +
Sbjct: 34 VAGEIVLITGAGHGIGRQTTYEFAKRQS-----ILVLWDINKRG-VEETAAECRKLGVTA 87
Query: 61 ETLQLDVRDSKSVAAARERVTE--GRVDVLVCNAGLGLLGPLEALGEDAVASVLDVNVVG 118
+D + + + + +V + G V ++V NAG L + ++ + +VN++G
Sbjct: 88 HAYVVDCSNREEIYRSLNQVKKEVGDVTIVVNNAGTVYPADLLSTKDEEITKTFEVNILG 147
Query: 119 TVRMLQAFLPDMKRRGSGRVLVTGSVGGLMGLPFNDVYCASKFALEGLCESLAVLLLPFG 178
+ +A LP M R G ++ SV G G+P+ YC+SKFA G L L G
Sbjct: 148 HFWITKALLPSMMERNHGHIVTVASVCGHEGIPYLIPYCSSKFAAVGFHRGLTSELQALG 207
>gi|31542939 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform 1
[Homo sapiens]
Length = 266
Score = 60.1 bits (144), Expect = 3e-09
Identities = 59/200 (29%), Positives = 87/200 (43%), Gaps = 19/200 (9%)
Query: 5 VVLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARALACPPGSLETLQ 64
V L+TG + GIG A L ++ V L G +AA P +Q
Sbjct: 7 VALVTGAAQGIGRAFAEALLLKGAKVALVDWNLE----AGVQCKAALDEQFEPQKTLFIQ 62
Query: 65 LDVRDSKSVAAARERVTE--GRVDVLVCNAGLGLLGPLEALGEDAVASVLDVNVVGTVRM 122
DV D + + +V + GR+D+LV NAG+ E L +N+V +
Sbjct: 63 CDVADQQQLRDTFRKVVDHFGRLDILVNNAGVN--------NEKNWEKTLQINLVSVISG 114
Query: 123 LQAFLPDMKRRGSGR---VLVTGSVGGLMGLPFNDVYCASKFALEGLCES--LAVLLLPF 177
L M ++ G ++ S+ GLM + VYCASK + G S LA L+
Sbjct: 115 TYLGLDYMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAALAANLMNS 174
Query: 178 GVHLSLIECGPVHTAFMEKV 197
GV L+ I G V+TA +E +
Sbjct: 175 GVRLNAICPGFVNTAILESI 194
>gi|40807363 epidermal retinal dehydrogenase 2 [Homo sapiens]
Length = 309
Score = 57.8 bits (138), Expect = 1e-08
Identities = 50/174 (28%), Positives = 74/174 (42%), Gaps = 7/174 (4%)
Query: 1 MARTVVLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARALACPPGSL 60
+A +VLITG SG+G LA++ A S L D+ +G A +
Sbjct: 38 VAGEIVLITGAGSGLGRLLALQFARLGS-----VLVLWDINKEGNEETCKMAREAGATRV 92
Query: 61 ETLQLDVRDSKSVAAARERVTE--GRVDVLVCNAGLGLLGPLEALGEDAVASVLDVNVVG 118
D + V ++V + G V +L+ NAG+ ++ + DVN
Sbjct: 93 HAYTCDCSQKEGVYRVADQVKKEVGDVSILINNAGIVTGKKFLDCPDELMEKSFDVNFKA 152
Query: 119 TVRMLQAFLPDMKRRGSGRVLVTGSVGGLMGLPFNDVYCASKFALEGLCESLAV 172
+ +AFLP M G ++ S GL G+ YCASKFA G ES+ V
Sbjct: 153 HLWTYKAFLPAMIANDHGHLVCISSSAGLSGVNGLADYCASKFAAFGFAESVFV 206
>gi|126723750 dehydrogenase/reductase (SDR family) member 4 like 1
[Homo sapiens]
Length = 281
Score = 57.4 bits (137), Expect = 2e-08
Identities = 56/204 (27%), Positives = 92/204 (45%), Gaps = 22/204 (10%)
Query: 1 MARTVVLITGCSSGIGLHLAVRLASDPS-------QSFKVYATLRDLKTQGRLWEAARAL 53
+ V L+T + IG +A RLA D + + V + L+ +G +
Sbjct: 30 LTNKVALVTASTDWIGFAVAQRLAQDGAHVVVSRRKQQNVDQAVATLQGEGL---SMTGT 86
Query: 54 ACPPGSLETLQLDVRDSKSVAAARERVTEGRVDVL---VCNAGLGLLG-PLEALGEDAVA 109
C G ++ + + VA A + G +D+L + N+ GL L E+A
Sbjct: 87 VCHVGKMKDWE------RLVATAMK--LHGVIDILSLSITNSKRGLFWFTLLQTAEEAWD 138
Query: 110 SVLDVNVVGTVRMLQAFLPDMKRRGSGRVLVTGSVGGLMGLPFNDVYCASKFALEGLCES 169
LD+N M++A +P+M++RG G V SV LP Y SK AL GL ++
Sbjct: 139 RNLDINGKALALMIKAVVPEMEKRGGGSVGFLASVAAFRPLPGFSPYNVSKTALLGLNKT 198
Query: 170 LAVLLLPFGVHLSLIECGPVHTAF 193
LA+ L P + ++ + G + T+F
Sbjct: 199 LAIELAPRNIRVNCLAPGLIKTSF 222
>gi|25282469 retinol dehydrogenase 10 [Homo sapiens]
Length = 341
Score = 56.2 bits (134), Expect = 4e-08
Identities = 58/197 (29%), Positives = 79/197 (40%), Gaps = 31/197 (15%)
Query: 1 MARTVVLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQG------------RLWE 48
+A V LITG SG+G A+ A + L D+ TQ R E
Sbjct: 34 VAGQVCLITGAGSGLGRLFALEFARR-----RALLVLWDINTQSNEETAGMVRHIYRDLE 88
Query: 49 AARALACPPGSLE--------------TLQLDVRDSKSVAAARERVTEGRVDVLVCNAGL 94
AA A A G+ E T + R++ + A R R G V VLV NAG+
Sbjct: 89 AADAAALQAGNGEEEILPHCNLQVFTYTCDVGKRENVYLTAERVRKEVGEVSVLVNNAGV 148
Query: 95 GLLGPLEALGEDAVASVLDVNVVGTVRMLQAFLPDMKRRGSGRVLVTGSVGGLMGLPFND 154
L ++ + + VN +AFLP M G ++ S GL +
Sbjct: 149 VSGHHLLECPDELIERTMMVNCHAHFWTTKAFLPTMLEINHGHIVTVASSLGLFSTAGVE 208
Query: 155 VYCASKFALEGLCESLA 171
YCASKF + G ESL+
Sbjct: 209 DYCASKFGVVGFHESLS 225
>gi|10190704 2,4-dienoyl CoA reductase 2 [Homo sapiens]
Length = 292
Score = 56.2 bits (134), Expect = 4e-08
Identities = 52/203 (25%), Positives = 86/203 (42%), Gaps = 7/203 (3%)
Query: 5 VVLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARALACPPGSLETLQ 64
V ITG SGIG +A + +L + T R A C P L
Sbjct: 30 VAFITGGGSGIGFRIAEIFMRHGCHTVIASRSLPRVLTAARKLAGATGRRCLP-----LS 84
Query: 65 LDVRDSKSVAAARERVTE--GRVDVLVCNAGLGLLGPLEALGEDAVASVLDVNVVGTVRM 122
+DVR +V AA ++ + GR+D+L+ A L P AL +A +V+D++ GT +
Sbjct: 85 MDVRAPPAVMAAVDQALKEFGRIDILINCAAGNFLCPAGALSFNAFKTVMDIDTSGTFNV 144
Query: 123 LQAFLPDMKRRGSGRVLVTGSVGGLMGLPFNDVYCASKFALEGLCESLAVLLLPFGVHLS 182
+ R G ++ + G G ++K A++ + LAV P + ++
Sbjct: 145 SRVLYEKFFRDHGGVIVNITATLGNRGQALQVHAGSAKAAVDAMTRHLAVEWGPQNIRVN 204
Query: 183 LIECGPVHTAFMEKVLGSPEEVL 205
+ GP+ + LG P+ L
Sbjct: 205 SLAPGPISGTEGLRRLGGPQASL 227
>gi|210032112 hydroxysteroid (17-beta) dehydrogenase 13 isoform B
[Homo sapiens]
Length = 264
Score = 55.5 bits (132), Expect = 7e-08
Identities = 31/96 (32%), Positives = 47/96 (48%)
Query: 83 GRVDVLVCNAGLGLLGPLEALGEDAVASVLDVNVVGTVRMLQAFLPDMKRRGSGRVLVTG 142
G V ++V NAG L + ++ + +VN++G + +A LP M R G ++
Sbjct: 76 GDVTIVVNNAGTVYPADLLSTKDEEITKTFEVNILGHFWITKALLPSMMERNHGHIVTVA 135
Query: 143 SVGGLMGLPFNDVYCASKFALEGLCESLAVLLLPFG 178
SV G G+P+ YC+SKFA G L L G
Sbjct: 136 SVCGHEGIPYLIPYCSSKFAAVGFHRGLTSELQALG 171
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.137 0.403
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,172,574
Number of Sequences: 37866
Number of extensions: 617225
Number of successful extensions: 3358
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 69
Number of HSP's successfully gapped in prelim test: 47
Number of HSP's that attempted gapping in prelim test: 3159
Number of HSP's gapped (non-prelim): 160
length of query: 328
length of database: 18,247,518
effective HSP length: 103
effective length of query: 225
effective length of database: 14,347,320
effective search space: 3228147000
effective search space used: 3228147000
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.