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Search of human proteins with 223671888
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|223671888 interleukin-1 receptor-associated kinase 4 isoform
b [Homo sapiens]
(336 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|223671888 interleukin-1 receptor-associated kinase 4 isoform ... 674 0.0
gi|223671885 interleukin-1 receptor-associated kinase 4 isoform ... 674 0.0
gi|223671883 interleukin-1 receptor-associated kinase 4 isoform ... 674 0.0
gi|166795293 interleukin-1 receptor-associated kinase 4 isoform ... 674 0.0
gi|166795295 interleukin-1 receptor-associated kinase 4 isoform ... 674 0.0
gi|68800243 interleukin-1 receptor-associated kinase 1 isoform 1... 171 1e-42
gi|68800343 interleukin-1 receptor-associated kinase 1 isoform 2... 167 2e-41
gi|68800350 interleukin-1 receptor-associated kinase 1 isoform 3... 164 1e-40
gi|216547519 interleukin-1 receptor-associated kinase 3 isoform ... 144 1e-34
gi|216547504 interleukin-1 receptor-associated kinase 3 isoform ... 144 1e-34
gi|58530886 interleukin-1 receptor-associated kinase 2 [Homo sap... 134 1e-31
gi|33188459 B-Raf [Homo sapiens] 120 1e-27
gi|4506401 v-raf-1 murine leukemia viral oncogene homolog 1 [Hom... 115 7e-26
gi|112789548 lymphocyte-specific protein tyrosine kinase precurs... 106 3e-23
gi|112789546 lymphocyte-specific protein tyrosine kinase precurs... 106 3e-23
gi|162287326 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog ... 105 6e-23
gi|4505055 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog is... 105 6e-23
gi|33469982 B lymphoid tyrosine kinase [Homo sapiens] 105 7e-23
gi|21450844 megakaryocyte-associated tyrosine kinase isoform c [... 104 1e-22
gi|21450842 megakaryocyte-associated tyrosine kinase isoform b [... 104 1e-22
gi|21450846 megakaryocyte-associated tyrosine kinase isoform a [... 104 1e-22
gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo sap... 103 2e-22
gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo sapi... 103 2e-22
gi|4758696 mitogen-activated protein kinase kinase kinase 13 [Ho... 103 2e-22
gi|4885661 viral oncogene yes-1 homolog 1 [Homo sapiens] 103 3e-22
gi|4502193 v-raf murine sarcoma 3611 viral oncogene homolog [Hom... 103 3e-22
gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo... 102 4e-22
gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens] 102 5e-22
gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens] 102 5e-22
gi|21735550 mitogen-activated protein kinase kinase kinase 10 [H... 101 8e-22
>gi|223671888 interleukin-1 receptor-associated kinase 4 isoform b
[Homo sapiens]
Length = 336
Score = 674 bits (1739), Expect = 0.0
Identities = 336/336 (100%), Positives = 336/336 (100%)
Query: 1 MPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERP 60
MPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERP
Sbjct: 1 MPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERP 60
Query: 61 ISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHEN 120
ISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHEN
Sbjct: 61 ISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHEN 120
Query: 121 LVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHE 180
LVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHE
Sbjct: 121 LVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHE 180
Query: 181 NHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEI 240
NHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEI
Sbjct: 181 NHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEI 240
Query: 241 TPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADST 300
TPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADST
Sbjct: 241 TPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADST 300
Query: 301 SVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 336
SVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
Sbjct: 301 SVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 336
>gi|223671885 interleukin-1 receptor-associated kinase 4 isoform b
[Homo sapiens]
Length = 336
Score = 674 bits (1739), Expect = 0.0
Identities = 336/336 (100%), Positives = 336/336 (100%)
Query: 1 MPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERP 60
MPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERP
Sbjct: 1 MPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERP 60
Query: 61 ISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHEN 120
ISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHEN
Sbjct: 61 ISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHEN 120
Query: 121 LVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHE 180
LVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHE
Sbjct: 121 LVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHE 180
Query: 181 NHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEI 240
NHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEI
Sbjct: 181 NHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEI 240
Query: 241 TPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADST 300
TPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADST
Sbjct: 241 TPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADST 300
Query: 301 SVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 336
SVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
Sbjct: 301 SVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 336
>gi|223671883 interleukin-1 receptor-associated kinase 4 isoform b
[Homo sapiens]
Length = 336
Score = 674 bits (1739), Expect = 0.0
Identities = 336/336 (100%), Positives = 336/336 (100%)
Query: 1 MPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERP 60
MPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERP
Sbjct: 1 MPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERP 60
Query: 61 ISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHEN 120
ISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHEN
Sbjct: 61 ISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHEN 120
Query: 121 LVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHE 180
LVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHE
Sbjct: 121 LVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHE 180
Query: 181 NHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEI 240
NHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEI
Sbjct: 181 NHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEI 240
Query: 241 TPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADST 300
TPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADST
Sbjct: 241 TPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADST 300
Query: 301 SVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 336
SVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
Sbjct: 301 SVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 336
>gi|166795293 interleukin-1 receptor-associated kinase 4 isoform a
[Homo sapiens]
Length = 460
Score = 674 bits (1739), Expect = 0.0
Identities = 336/336 (100%), Positives = 336/336 (100%)
Query: 1 MPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERP 60
MPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERP
Sbjct: 125 MPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERP 184
Query: 61 ISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHEN 120
ISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHEN
Sbjct: 185 ISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHEN 244
Query: 121 LVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHE 180
LVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHE
Sbjct: 245 LVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHE 304
Query: 181 NHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEI 240
NHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEI
Sbjct: 305 NHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEI 364
Query: 241 TPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADST 300
TPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADST
Sbjct: 365 TPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADST 424
Query: 301 SVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 336
SVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
Sbjct: 425 SVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 460
>gi|166795295 interleukin-1 receptor-associated kinase 4 isoform a
[Homo sapiens]
Length = 460
Score = 674 bits (1739), Expect = 0.0
Identities = 336/336 (100%), Positives = 336/336 (100%)
Query: 1 MPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERP 60
MPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERP
Sbjct: 125 MPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERP 184
Query: 61 ISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHEN 120
ISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHEN
Sbjct: 185 ISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHEN 244
Query: 121 LVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHE 180
LVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHE
Sbjct: 245 LVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHE 304
Query: 181 NHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEI 240
NHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEI
Sbjct: 305 NHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEI 364
Query: 241 TPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADST 300
TPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADST
Sbjct: 365 TPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADST 424
Query: 301 SVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 336
SVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
Sbjct: 425 SVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 460
>gi|68800243 interleukin-1 receptor-associated kinase 1 isoform 1
[Homo sapiens]
Length = 712
Score = 171 bits (432), Expect = 1e-42
Identities = 110/326 (33%), Positives = 165/326 (50%), Gaps = 44/326 (13%)
Query: 48 ELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFD 107
E+ T+NF E K+GEGGFG VY+ + NT AVK+L D+ +KQ F
Sbjct: 204 EISRGTHNFSEEL------KIGEGGFGCVYRAVMRNTVYAVKRLKENADLEWTAVKQSFL 257
Query: 108 QEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSC-LDGTPPLSWHMRCK 166
E++ +++ +H N+V+ G+ + CLVY ++PNGSL DRL C PPLSW R
Sbjct: 258 TEVEQLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWPQRLD 317
Query: 167 IAQGAANGINFLHENHH--IHRDIKSANILLDEAFTAKISDFGLARASE-------KFAQ 217
I G A I FLH++ IH DIKS+N+LLDE T K+ DFGLAR S + +
Sbjct: 318 ILLGTARAIQFLHQDSPSLIHGDIKSSNVLLDERLTPKLGDFGLARFSRFAGSSPSQSSM 377
Query: 218 TVMTSRIVGTTAYMAPEALR-GEITPKSDIYSFGVVLLEIITGLPAVDEH-REPQLLLDI 275
T + GT AY+ E ++ G + +D +SFGVV+LE + G AV H + L D+
Sbjct: 378 VARTQTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVVVLETLAGQRAVKTHGARTKYLKDL 437
Query: 276 KEEIEDE--------EKTIE------------------DYIDKKMNDADSTSVEAMYSVA 309
EE +E + T++ ++D + + +A
Sbjct: 438 VEEEAEEAGVALRSTQSTLQAGLAADAWAAPIAMQIYKKHLDPRPGPCPPELGLGLGQLA 497
Query: 310 SQCLHEKKNKRPDIKKVQQLLQEMTA 335
CLH + +RP + +V + L+++ A
Sbjct: 498 CCCLHRRAKRRPPMTQVYERLEKLQA 523
>gi|68800343 interleukin-1 receptor-associated kinase 1 isoform 2
[Homo sapiens]
Length = 682
Score = 167 bits (422), Expect = 2e-41
Identities = 99/247 (40%), Positives = 138/247 (55%), Gaps = 18/247 (7%)
Query: 48 ELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFD 107
E+ T+NF E K+GEGGFG VY+ + NT AVK+L D+ +KQ F
Sbjct: 204 EISRGTHNFSEEL------KIGEGGFGCVYRAVMRNTVYAVKRLKENADLEWTAVKQSFL 257
Query: 108 QEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSC-LDGTPPLSWHMRCK 166
E++ +++ +H N+V+ G+ + CLVY ++PNGSL DRL C PPLSW R
Sbjct: 258 TEVEQLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWPQRLD 317
Query: 167 IAQGAANGINFLHENHH--IHRDIKSANILLDEAFTAKISDFGLARASE-------KFAQ 217
I G A I FLH++ IH DIKS+N+LLDE T K+ DFGLAR S + +
Sbjct: 318 ILLGTARAIQFLHQDSPSLIHGDIKSSNVLLDERLTPKLGDFGLARFSRFAGSSPSQSSM 377
Query: 218 TVMTSRIVGTTAYMAPEALR-GEITPKSDIYSFGVVLLEIITGLPAVDEH-REPQLLLDI 275
T + GT AY+ E ++ G + +D +SFGVV+LE + G AV H + L D+
Sbjct: 378 VARTQTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVVVLETLAGQRAVKTHGARTKYLKDL 437
Query: 276 KEEIEDE 282
EE +E
Sbjct: 438 VEEEAEE 444
>gi|68800350 interleukin-1 receptor-associated kinase 1 isoform 3
[Homo sapiens]
Length = 633
Score = 164 bits (415), Expect = 1e-40
Identities = 94/230 (40%), Positives = 130/230 (56%), Gaps = 17/230 (7%)
Query: 48 ELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFD 107
E+ T+NF E K+GEGGFG VY+ + NT AVK+L D+ +KQ F
Sbjct: 204 EISRGTHNFSEEL------KIGEGGFGCVYRAVMRNTVYAVKRLKENADLEWTAVKQSFL 257
Query: 108 QEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSC-LDGTPPLSWHMRCK 166
E++ +++ +H N+V+ G+ + CLVY ++PNGSL DRL C PPLSW R
Sbjct: 258 TEVEQLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWPQRLD 317
Query: 167 IAQGAANGINFLHENHH--IHRDIKSANILLDEAFTAKISDFGLARAS-------EKFAQ 217
I G A I FLH++ IH DIKS+N+LLDE T K+ DFGLAR S + +
Sbjct: 318 ILLGTARAIQFLHQDSPSLIHGDIKSSNVLLDERLTPKLGDFGLARFSRFAGSSPSQSSM 377
Query: 218 TVMTSRIVGTTAYMAPEALR-GEITPKSDIYSFGVVLLEIITGLPAVDEH 266
T + GT AY+ E ++ G + +D +SFGVV+LE + G AV H
Sbjct: 378 VARTQTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVVVLETLAGQRAVKTH 427
>gi|216547519 interleukin-1 receptor-associated kinase 3 isoform a
[Homo sapiens]
Length = 596
Score = 144 bits (363), Expect = 1e-34
Identities = 91/304 (29%), Positives = 155/304 (50%), Gaps = 16/304 (5%)
Query: 43 SFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEEL 102
S SF + T NF + + +GEG VY+ + N T AVK + ++
Sbjct: 152 SISFQNIIEGTRNFHKDFL------IGEGEIFEVYRVEIQNLTYAVKLFKQEKKMQCKKH 205
Query: 103 KQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWH 162
++F E++V+ H N++EL + ++ + CL+Y YM NG+L DRL C+ T PL WH
Sbjct: 206 WKRFLSELEVLLLFHHPNILELAAYFTETEKFCLIYPYMRNGTLFDRLQCVGDTAPLPWH 265
Query: 163 MRCKIAQGAANGINFLHENHH---IHRDIKSANILLDEAFTAKISDFGLARASEKFAQTV 219
+R I G + I++LH I I SANILLD+ F K++DF +A
Sbjct: 266 IRIGILIGISKAIHYLHNVQPCSVICGSISSANILLDDQFQPKLTDFAMAHFRSHLEHQS 325
Query: 220 MTSRIVGTTA----YMAPEALR-GEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLD 274
T + +++ YM E +R G+++ K+D+YSFG+V++E++TG V + + L D
Sbjct: 326 CTINMTSSSSKHLWYMPEEYIRQGKLSIKTDVYSFGIVIMEVLTGCRVVLDDPKHIQLRD 385
Query: 275 IKEEIEDEE--KTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQE 332
+ E+ ++ + ++DKK+ ++ +A +C + RP + +V L+
Sbjct: 386 LLRELMEKRGLDSCLSFLDKKVPPCPRNFSAKLFCLAGRCAATRAKLRPSMDEVLNTLES 445
Query: 333 MTAS 336
AS
Sbjct: 446 TQAS 449
>gi|216547504 interleukin-1 receptor-associated kinase 3 isoform b
[Homo sapiens]
Length = 535
Score = 144 bits (363), Expect = 1e-34
Identities = 91/304 (29%), Positives = 155/304 (50%), Gaps = 16/304 (5%)
Query: 43 SFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEEL 102
S SF + T NF + + +GEG VY+ + N T AVK + ++
Sbjct: 91 SISFQNIIEGTRNFHKDFL------IGEGEIFEVYRVEIQNLTYAVKLFKQEKKMQCKKH 144
Query: 103 KQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWH 162
++F E++V+ H N++EL + ++ + CL+Y YM NG+L DRL C+ T PL WH
Sbjct: 145 WKRFLSELEVLLLFHHPNILELAAYFTETEKFCLIYPYMRNGTLFDRLQCVGDTAPLPWH 204
Query: 163 MRCKIAQGAANGINFLHENHH---IHRDIKSANILLDEAFTAKISDFGLARASEKFAQTV 219
+R I G + I++LH I I SANILLD+ F K++DF +A
Sbjct: 205 IRIGILIGISKAIHYLHNVQPCSVICGSISSANILLDDQFQPKLTDFAMAHFRSHLEHQS 264
Query: 220 MTSRIVGTTA----YMAPEALR-GEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLD 274
T + +++ YM E +R G+++ K+D+YSFG+V++E++TG V + + L D
Sbjct: 265 CTINMTSSSSKHLWYMPEEYIRQGKLSIKTDVYSFGIVIMEVLTGCRVVLDDPKHIQLRD 324
Query: 275 IKEEIEDEE--KTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQE 332
+ E+ ++ + ++DKK+ ++ +A +C + RP + +V L+
Sbjct: 325 LLRELMEKRGLDSCLSFLDKKVPPCPRNFSAKLFCLAGRCAATRAKLRPSMDEVLNTLES 384
Query: 333 MTAS 336
AS
Sbjct: 385 TQAS 388
>gi|58530886 interleukin-1 receptor-associated kinase 2 [Homo
sapiens]
Length = 625
Score = 134 bits (336), Expect = 1e-31
Identities = 80/278 (28%), Positives = 139/278 (50%), Gaps = 21/278 (7%)
Query: 67 KMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLG 126
K+ +G F VY+G+ + KKL + +++ F E+++ +C H N++ +LG
Sbjct: 215 KISQGTFADVYRGHRHGKPFVFKKLRETACSSPGSIERFFQAELQICLRCCHPNVLPVLG 274
Query: 127 FSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHR 186
F + +Y YM NGSL DRL G+ PL W R I G + +LH IH
Sbjct: 275 FCAARQFHSFIYPYMANGSLQDRLQGQGGSDPLPWPQRVSICSGLLCAVEYLHGLEIIHS 334
Query: 187 DIKSANILLDEAFTAKISD--FGLARASEKFAQTVMTSRIVGTTAYMAPEAL--RGEITP 242
++KS+N+LLD+ T K++ L +++ T+M + ++ T+A PE G++T
Sbjct: 335 NVKSSNVLLDQNLTPKLAHPMAHLCPVNKRSKYTMMKTHLLRTSAAYLPEDFIRVGQLTK 394
Query: 243 KSDIYSFGVVLLEIITGLPAVDEHREPQLLLDI---------------KEEIED--EEKT 285
+ DI+S G+VL E++TG+PA+D +R P L D+ K +E+ ++
Sbjct: 395 RVDIFSCGIVLAEVLTGIPAMDNNRSPVYLKDLLLSDIPSSTASLCSRKTGVENVMAKEI 454
Query: 286 IEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDI 323
+ Y++K EA+ + A CL + ++
Sbjct: 455 CQKYLEKGAGRLPEDCAEALATAACLCLRRRNTSLQEV 492
>gi|33188459 B-Raf [Homo sapiens]
Length = 766
Score = 120 bits (302), Expect = 1e-27
Identities = 82/262 (31%), Positives = 135/262 (51%), Gaps = 21/262 (8%)
Query: 65 GNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVEL 124
G ++G G FG VYKG + VAVK L V T + Q F E+ V+ K +H N++
Sbjct: 460 GQRIGSGSFGTVYKGKWHGD-VAVKMLN--VTAPTPQQLQAFKNEVGVLRKTRHVNILLF 516
Query: 125 LGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHI 184
+G+S+ L +V + SL L ++ IA+ A G+++LH I
Sbjct: 517 MGYSTK-PQLAIVTQWCEGSSLYHHLHIIE--TKFEMIKLIDIARQTAQGMDYLHAKSII 573
Query: 185 HRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALR----GEI 240
HRD+KS NI L E T KI DFGLA +++ + ++ G+ +MAPE +R
Sbjct: 574 HRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPY 633
Query: 241 TPKSDIYSFGVVLLEIITG-LPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADS 299
+ +SD+Y+FG+VL E++TG LP + + Q++ + Y+ ++ S
Sbjct: 634 SFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVG----------RGYLSPDLSKVRS 683
Query: 300 TSVEAMYSVASQCLHEKKNKRP 321
+AM + ++CL +K+++RP
Sbjct: 684 NCPKAMKRLMAECLKKKRDERP 705
>gi|4506401 v-raf-1 murine leukemia viral oncogene homolog 1 [Homo
sapiens]
Length = 648
Score = 115 bits (287), Expect = 7e-26
Identities = 81/260 (31%), Positives = 131/260 (50%), Gaps = 21/260 (8%)
Query: 67 KMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLG 126
++G G FG VYKG + VAVK L +VD T E+ Q F E+ V+ K +H N++ +G
Sbjct: 354 RIGSGSFGTVYKGKWHGD-VAVKILK-VVDPTPEQF-QAFRNEVAVLRKTRHVNILLFMG 410
Query: 127 FSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHR 186
+ + D+L +V + SL L + IA+ A G+++LH + IHR
Sbjct: 411 YMTK-DNLAIVTQWCEGSSLYKHLHVQE--TKFQMFQLIDIARQTAQGMDYLHAKNIIHR 467
Query: 187 DIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALR----GEITP 242
D+KS NI L E T KI DFGLA +++ + + G+ +MAPE +R +
Sbjct: 468 DMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSF 527
Query: 243 KSDIYSFGVVLLEIITG-LPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTS 301
+SD+YS+G+VL E++TG LP + Q++ + Y ++
Sbjct: 528 QSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVG----------RGYASPDLSKLYKNC 577
Query: 302 VEAMYSVASQCLHEKKNKRP 321
+AM + + C+ + K +RP
Sbjct: 578 PKAMKRLVADCVKKVKEERP 597
>gi|112789548 lymphocyte-specific protein tyrosine kinase precursor
[Homo sapiens]
Length = 509
Score = 106 bits (264), Expect = 3e-23
Identities = 85/268 (31%), Positives = 133/268 (49%), Gaps = 23/268 (8%)
Query: 67 KMGEGGFGVVYKGYVN-NTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELL 125
++G G FG V+ GY N +T VAVK L F E +M + QH+ LV L
Sbjct: 250 RLGAGQFGEVWMGYYNGHTKVAVKSLKQ-----GSMSPDAFLAEANLMKQLQHQRLVRLY 304
Query: 126 GFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIH 185
+ + + ++ YM NGSL+D L G L+ + +A A G+ F+ E ++IH
Sbjct: 305 AVVTQ-EPIYIITEYMENGSLVDFLKTPSGIK-LTINKLLDMAAQIAEGMAFIEERNYIH 362
Query: 186 RDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALR-GEITPKS 244
RD+++ANIL+ + + KI+DFGLAR E T + APEA+ G T KS
Sbjct: 363 RDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKF-PIKWTAPEAINYGTFTIKS 421
Query: 245 DIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEA 304
D++SFG++L EI+T R P + E I++ E+ +M D+ E
Sbjct: 422 DVWSFGILLTEIVT------HGRIPYPGMTNPEVIQNLER------GYRMVRPDNCP-EE 468
Query: 305 MYSVASQCLHEKKNKRPDIKKVQQLLQE 332
+Y + C E+ RP ++ +L++
Sbjct: 469 LYQLMRLCWKERPEDRPTFDYLRSVLED 496
>gi|112789546 lymphocyte-specific protein tyrosine kinase precursor
[Homo sapiens]
Length = 509
Score = 106 bits (264), Expect = 3e-23
Identities = 85/268 (31%), Positives = 133/268 (49%), Gaps = 23/268 (8%)
Query: 67 KMGEGGFGVVYKGYVN-NTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELL 125
++G G FG V+ GY N +T VAVK L F E +M + QH+ LV L
Sbjct: 250 RLGAGQFGEVWMGYYNGHTKVAVKSLKQ-----GSMSPDAFLAEANLMKQLQHQRLVRLY 304
Query: 126 GFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIH 185
+ + + ++ YM NGSL+D L G L+ + +A A G+ F+ E ++IH
Sbjct: 305 AVVTQ-EPIYIITEYMENGSLVDFLKTPSGIK-LTINKLLDMAAQIAEGMAFIEERNYIH 362
Query: 186 RDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALR-GEITPKS 244
RD+++ANIL+ + + KI+DFGLAR E T + APEA+ G T KS
Sbjct: 363 RDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKF-PIKWTAPEAINYGTFTIKS 421
Query: 245 DIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEA 304
D++SFG++L EI+T R P + E I++ E+ +M D+ E
Sbjct: 422 DVWSFGILLTEIVT------HGRIPYPGMTNPEVIQNLER------GYRMVRPDNCP-EE 468
Query: 305 MYSVASQCLHEKKNKRPDIKKVQQLLQE 332
+Y + C E+ RP ++ +L++
Sbjct: 469 LYQLMRLCWKERPEDRPTFDYLRSVLED 496
>gi|162287326 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog
isoform B [Homo sapiens]
Length = 491
Score = 105 bits (262), Expect = 6e-23
Identities = 85/272 (31%), Positives = 127/272 (46%), Gaps = 30/272 (11%)
Query: 67 KMGEGGFGVVYKGYVNNTT-VAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELL 125
++G G FG V+ GY NN+T VAVK L Q F +E +M QH+ LV L
Sbjct: 231 RLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSV-----QAFLEEANLMKTLQHDKLVRLY 285
Query: 126 GFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIH 185
+ + + ++ YM GSLLD L +G L + AQ A G+ ++ ++IH
Sbjct: 286 AVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQ-IAEGMAYIERKNYIH 344
Query: 186 RDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALR-GEITPKS 244
RD+++AN+L+ E+ KI+DFGLAR E T + APEA+ G T KS
Sbjct: 345 RDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKF-PIKWTAPEAINFGCFTIKS 403
Query: 245 DIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVE- 303
D++SFG++L EI+T +I +T D + VE
Sbjct: 404 DVWSFGILLYEIVT-----------------YGKIPYPGRTNADVMTALSQGYRMPRVEN 446
Query: 304 ---AMYSVASQCLHEKKNKRPDIKKVQQLLQE 332
+Y + C EK +RP +Q +L +
Sbjct: 447 CPDELYDIMKMCWKEKAEERPTFDYLQSVLDD 478
>gi|4505055 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog
isoform A [Homo sapiens]
Length = 512
Score = 105 bits (262), Expect = 6e-23
Identities = 85/272 (31%), Positives = 127/272 (46%), Gaps = 30/272 (11%)
Query: 67 KMGEGGFGVVYKGYVNNTT-VAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELL 125
++G G FG V+ GY NN+T VAVK L Q F +E +M QH+ LV L
Sbjct: 252 RLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSV-----QAFLEEANLMKTLQHDKLVRLY 306
Query: 126 GFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIH 185
+ + + ++ YM GSLLD L +G L + AQ A G+ ++ ++IH
Sbjct: 307 AVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQ-IAEGMAYIERKNYIH 365
Query: 186 RDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALR-GEITPKS 244
RD+++AN+L+ E+ KI+DFGLAR E T + APEA+ G T KS
Sbjct: 366 RDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKF-PIKWTAPEAINFGCFTIKS 424
Query: 245 DIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVE- 303
D++SFG++L EI+T +I +T D + VE
Sbjct: 425 DVWSFGILLYEIVT-----------------YGKIPYPGRTNADVMTALSQGYRMPRVEN 467
Query: 304 ---AMYSVASQCLHEKKNKRPDIKKVQQLLQE 332
+Y + C EK +RP +Q +L +
Sbjct: 468 CPDELYDIMKMCWKEKAEERPTFDYLQSVLDD 499
>gi|33469982 B lymphoid tyrosine kinase [Homo sapiens]
Length = 505
Score = 105 bits (261), Expect = 7e-23
Identities = 90/270 (33%), Positives = 133/270 (49%), Gaps = 27/270 (10%)
Query: 67 KMGEGGFGVVYKGYV-NNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELL 125
K+G G FG V+ GY NN VA+K L + F E VM QHE LV L
Sbjct: 246 KLGSGQFGEVWMGYYKNNMKVAIKTLKEGT-----MSPEAFLGEANVMKALQHERLVRLY 300
Query: 126 GFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIH 185
+ + + +V YM G LLD L +G+ LS ++ A G+ ++ + IH
Sbjct: 301 AVVTK-EPIYIVTEYMARGCLLDFLKTDEGSR-LSLPRLIDMSAQIAEGMAYIERMNSIH 358
Query: 186 RDIKSANILLDEAFTAKISDFGLARA--SEKFAQTVMTSRIVGTTAYMAPEALR-GEITP 242
RD+++ANIL+ EA KI+DFGLAR SE AQ I T APEA+ G T
Sbjct: 359 RDLRAANILVSEALCCKIADFGLARIIDSEYTAQEGAKFPIKWT----APEAIHFGVFTI 414
Query: 243 KSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSV 302
K+D++SFGV+L+E++T R P + E I + E+ +M D+
Sbjct: 415 KADVWSFGVLLMEVVT------YGRVPYPGMSNPEVIRNLER------GYRMPRPDTCPP 462
Query: 303 EAMYSVASQCLHEKKNKRPDIKKVQQLLQE 332
E V ++C + +RP + +Q +L++
Sbjct: 463 ELYRGVIAECWRSRPEERPTFEFLQSVLED 492
>gi|21450844 megakaryocyte-associated tyrosine kinase isoform c
[Homo sapiens]
Length = 466
Score = 104 bits (260), Expect = 1e-22
Identities = 87/267 (32%), Positives = 133/267 (49%), Gaps = 27/267 (10%)
Query: 65 GNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVEL 124
G ++GEG FG V +G VAVK + D+T Q F E VM K QHENLV L
Sbjct: 197 GAQIGEGEFGAVLQGEYLGQKVAVKNIKC--DVTA----QAFLDETAVMTKMQHENLVRL 250
Query: 125 LGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHI 184
LG L +V ++ G+L++ L G ++ + + A G+ +L +
Sbjct: 251 LGVILH-QGLYIVMEHVSKGNLVNFLRTR-GRALVNTAQLLQFSLHVAEGMEYLESKKLV 308
Query: 185 HRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALR-GEITPK 243
HRD+ + NIL+ E AK+SDFGLA+A K + +SR+ + APEAL+ G+ T K
Sbjct: 309 HRDLAARNILVSEDLVAKVSDFGLAKAERK---GLDSSRL--PVKWTAPEALKHGKFTSK 363
Query: 244 SDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVE 303
SD++SFGV+L E+ + R P + +KE E EK +M +
Sbjct: 364 SDVWSFGVLLWEVFS------YGRAPYPKMSLKEVSEAVEK------GYRMEPPEGCP-G 410
Query: 304 AMYSVASQCLHEKKNKRPDIKKVQQLL 330
++ + S C + +RP +K+ + L
Sbjct: 411 PVHVLMSSCWEAEPARRPPFRKLAEKL 437
>gi|21450842 megakaryocyte-associated tyrosine kinase isoform b
[Homo sapiens]
Length = 508
Score = 104 bits (260), Expect = 1e-22
Identities = 87/267 (32%), Positives = 133/267 (49%), Gaps = 27/267 (10%)
Query: 65 GNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVEL 124
G ++GEG FG V +G VAVK + D+T Q F E VM K QHENLV L
Sbjct: 239 GAQIGEGEFGAVLQGEYLGQKVAVKNIKC--DVTA----QAFLDETAVMTKMQHENLVRL 292
Query: 125 LGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHI 184
LG L +V ++ G+L++ L G ++ + + A G+ +L +
Sbjct: 293 LGVILH-QGLYIVMEHVSKGNLVNFLRTR-GRALVNTAQLLQFSLHVAEGMEYLESKKLV 350
Query: 185 HRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALR-GEITPK 243
HRD+ + NIL+ E AK+SDFGLA+A K + +SR+ + APEAL+ G+ T K
Sbjct: 351 HRDLAARNILVSEDLVAKVSDFGLAKAERK---GLDSSRL--PVKWTAPEALKHGKFTSK 405
Query: 244 SDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVE 303
SD++SFGV+L E+ + R P + +KE E EK +M +
Sbjct: 406 SDVWSFGVLLWEVFS------YGRAPYPKMSLKEVSEAVEK------GYRMEPPEGCP-G 452
Query: 304 AMYSVASQCLHEKKNKRPDIKKVQQLL 330
++ + S C + +RP +K+ + L
Sbjct: 453 PVHVLMSSCWEAEPARRPPFRKLAEKL 479
>gi|21450846 megakaryocyte-associated tyrosine kinase isoform a
[Homo sapiens]
Length = 507
Score = 104 bits (260), Expect = 1e-22
Identities = 87/267 (32%), Positives = 133/267 (49%), Gaps = 27/267 (10%)
Query: 65 GNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVEL 124
G ++GEG FG V +G VAVK + D+T Q F E VM K QHENLV L
Sbjct: 238 GAQIGEGEFGAVLQGEYLGQKVAVKNIKC--DVTA----QAFLDETAVMTKMQHENLVRL 291
Query: 125 LGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHI 184
LG L +V ++ G+L++ L G ++ + + A G+ +L +
Sbjct: 292 LGVILH-QGLYIVMEHVSKGNLVNFLRTR-GRALVNTAQLLQFSLHVAEGMEYLESKKLV 349
Query: 185 HRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALR-GEITPK 243
HRD+ + NIL+ E AK+SDFGLA+A K + +SR+ + APEAL+ G+ T K
Sbjct: 350 HRDLAARNILVSEDLVAKVSDFGLAKAERK---GLDSSRL--PVKWTAPEALKHGKFTSK 404
Query: 244 SDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVE 303
SD++SFGV+L E+ + R P + +KE E EK +M +
Sbjct: 405 SDVWSFGVLLWEVFS------YGRAPYPKMSLKEVSEAVEK------GYRMEPPEGCP-G 451
Query: 304 AMYSVASQCLHEKKNKRPDIKKVQQLL 330
++ + S C + +RP +K+ + L
Sbjct: 452 PVHVLMSSCWEAEPARRPPFRKLAEKL 478
>gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo
sapiens]
Length = 536
Score = 103 bits (258), Expect = 2e-22
Identities = 85/272 (31%), Positives = 134/272 (49%), Gaps = 23/272 (8%)
Query: 67 KMGEGGFGVVYKGYVNNTT-VAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELL 125
K+G+G FG V+ G N TT VA+K L + F QE +VM K +HE LV+L
Sbjct: 275 KLGQGCFGEVWMGTWNGTTRVAIKTLKPGT-----MSPEAFLQEAQVMKKLRHEKLVQLY 329
Query: 126 GFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIH 185
S+ + + +V YM GSLLD L G L +A A+G+ ++ +++H
Sbjct: 330 AVVSE-EPIYIVTEYMSKGSLLDFLKGETGKY-LRLPQLVDMAAQIASGMAYVERMNYVH 387
Query: 186 RDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPE-ALRGEITPKS 244
RD+++ANIL+ E K++DFGLAR E T + APE AL G T KS
Sbjct: 388 RDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKF-PIKWTAPEAALYGRFTIKS 446
Query: 245 DIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEA 304
D++SFG++L E+ T + R P + +E ++ E+ E+
Sbjct: 447 DVWSFGILLTELTT------KGRVPYPGMVNREVLDQVERGYR-------MPCPPECPES 493
Query: 305 MYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 336
++ + QC ++ +RP + +Q L++ S
Sbjct: 494 LHDLMCQCWRKEPEERPTFEYLQAFLEDYFTS 525
>gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo
sapiens]
Length = 536
Score = 103 bits (258), Expect = 2e-22
Identities = 85/272 (31%), Positives = 134/272 (49%), Gaps = 23/272 (8%)
Query: 67 KMGEGGFGVVYKGYVNNTT-VAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELL 125
K+G+G FG V+ G N TT VA+K L + F QE +VM K +HE LV+L
Sbjct: 275 KLGQGCFGEVWMGTWNGTTRVAIKTLKPGT-----MSPEAFLQEAQVMKKLRHEKLVQLY 329
Query: 126 GFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIH 185
S+ + + +V YM GSLLD L G L +A A+G+ ++ +++H
Sbjct: 330 AVVSE-EPIYIVTEYMSKGSLLDFLKGETGKY-LRLPQLVDMAAQIASGMAYVERMNYVH 387
Query: 186 RDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPE-ALRGEITPKS 244
RD+++ANIL+ E K++DFGLAR E T + APE AL G T KS
Sbjct: 388 RDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKF-PIKWTAPEAALYGRFTIKS 446
Query: 245 DIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEA 304
D++SFG++L E+ T + R P + +E ++ E+ E+
Sbjct: 447 DVWSFGILLTELTT------KGRVPYPGMVNREVLDQVERGYR-------MPCPPECPES 493
Query: 305 MYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 336
++ + QC ++ +RP + +Q L++ S
Sbjct: 494 LHDLMCQCWRKEPEERPTFEYLQAFLEDYFTS 525
>gi|4758696 mitogen-activated protein kinase kinase kinase 13 [Homo
sapiens]
Length = 966
Score = 103 bits (257), Expect = 2e-22
Identities = 64/193 (33%), Positives = 100/193 (51%), Gaps = 18/193 (9%)
Query: 68 MGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGF 127
+G G G V+ G VA+KK+ ++Q + +IK + K +H N++ G
Sbjct: 174 LGSGAQGAVFLGKFRAEEVAIKKV-----------REQNETDIKHLRKLKHPNIIAFKGV 222
Query: 128 SSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRD 187
+ C++ Y +G L + L P + + G A+G+N+LH + IHRD
Sbjct: 223 CTQAPCYCIIMEYCAHGQLYEVLRAGRKITP---RLLVDWSTGIASGMNYLHLHKIIHRD 279
Query: 188 IKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGE-ITPKSDI 246
+KS N+L+ KISDFG S++ + GT A+MAPE +R E ++ K DI
Sbjct: 280 LKSPNVLVTHTDAVKISDFG---TSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDI 336
Query: 247 YSFGVVLLEIITG 259
+SFGVVL E++TG
Sbjct: 337 WSFGVVLWELLTG 349
>gi|4885661 viral oncogene yes-1 homolog 1 [Homo sapiens]
Length = 543
Score = 103 bits (256), Expect = 3e-22
Identities = 83/268 (30%), Positives = 134/268 (50%), Gaps = 23/268 (8%)
Query: 67 KMGEGGFGVVYKGYVNNTT-VAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELL 125
K+G+G FG V+ G N TT VA+K L + + F QE ++M K +H+ LV L
Sbjct: 282 KLGQGCFGEVWMGTWNGTTKVAIKTLKPGT-----MMPEAFLQEAQIMKKLRHDKLVPLY 336
Query: 126 GFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIH 185
S+ + + +V +M GSLLD L DG L +A A+G+ ++ ++IH
Sbjct: 337 AVVSE-EPIYIVTEFMSKGSLLDFLKEGDGKY-LKLPQLVDMAAQIADGMAYIERMNYIH 394
Query: 186 RDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPE-ALRGEITPKS 244
RD+++ANIL+ E KI+DFGLAR E T + APE AL G T KS
Sbjct: 395 RDLRAANILVGENLVCKIADFGLARLIEDNEYTARQGAKF-PIKWTAPEAALYGRFTIKS 453
Query: 245 DIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEA 304
D++SFG++ E++T + R P + +E +E E+ E+
Sbjct: 454 DVWSFGILQTELVT------KGRVPYPGMVNREVLEQVERGYR-------MPCPQGCPES 500
Query: 305 MYSVASQCLHEKKNKRPDIKKVQQLLQE 332
++ + + C + ++RP + +Q L++
Sbjct: 501 LHELMNLCWKKDPDERPTFEYIQSFLED 528
>gi|4502193 v-raf murine sarcoma 3611 viral oncogene homolog [Homo
sapiens]
Length = 606
Score = 103 bits (256), Expect = 3e-22
Identities = 77/260 (29%), Positives = 125/260 (48%), Gaps = 21/260 (8%)
Query: 67 KMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLG 126
++G G FG V++G + VAVK L V T E Q F E++V+ K +H N++ +G
Sbjct: 315 RIGTGSFGTVFRGRWHGD-VAVKVLK--VSQPTAEQAQAFKNEMQVLRKTRHVNILLFMG 371
Query: 127 FSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHR 186
F + ++ + SL L D +A+ A G+++LH + IHR
Sbjct: 372 FMTR-PGFAIITQWCEGSSLYHHLHVADTR--FDMVQLIDVARQTAQGMDYLHAKNIIHR 428
Query: 187 DIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALR----GEITP 242
D+KS NI L E T KI DFGLA +++ + G+ +MA E +R +
Sbjct: 429 DLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSF 488
Query: 243 KSDIYSFGVVLLEIITG-LPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTS 301
+SD+Y++GVVL E++TG LP Q++ + Y+ ++ S
Sbjct: 489 QSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVG----------RGYLSPDLSKISSNC 538
Query: 302 VEAMYSVASQCLHEKKNKRP 321
+AM + S CL ++ +RP
Sbjct: 539 PKAMRRLLSDCLKFQREERP 558
>gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo
sapiens]
Length = 416
Score = 102 bits (255), Expect = 4e-22
Identities = 74/264 (28%), Positives = 128/264 (48%), Gaps = 20/264 (7%)
Query: 42 HSFSFYELKNVTNNF-DERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTE 100
HS ++ + NN D + ++G+G FG V+KG N T +++ A+ I E
Sbjct: 3 HSPVAVQVPGMQNNIADPEELFTKLERIGKGSFGEVFKGIDNRT----QQVVAIKIIDLE 58
Query: 101 ELKQQFD---QEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTP 157
E + + + QEI V+++C + + G G L ++ Y+ GS LD L
Sbjct: 59 EAEDEIEDIQQEITVLSQCDSSYVTKYYGSYLKGSKLWIIMEYLGGGSALDLLRA----G 114
Query: 158 PLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQ 217
P + + G+++LH IHRDIK+AN+LL E K++DFG+ A +
Sbjct: 115 PFDEFQIATMLKEILKGLDYLHSEKKIHRDIKAANVLLSEQGDVKLADFGV--AGQLTDT 172
Query: 218 TVMTSRIVGTTAYMAPEAL-RGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIK 276
+ + VGT +MAPE + + K+DI+S G+ +E+ G P + ++L I
Sbjct: 173 QIKRNTFVGTPFWMAPEVIQQSAYDSKADIWSLGITAIELAKGEPPNSDMHPMRVLFLIP 232
Query: 277 EE-----IEDEEKTIEDYIDKKMN 295
+ + D K+ +++ID +N
Sbjct: 233 KNNPPTLVGDFTKSFKEFIDACLN 256
>gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens]
Length = 431
Score = 102 bits (254), Expect = 5e-22
Identities = 79/264 (29%), Positives = 129/264 (48%), Gaps = 28/264 (10%)
Query: 67 KMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFD---QEIKVMAKCQHENLVE 123
K+G+G FG V+KG N T +K+ A+ I EE + + + QEI V+++C + +
Sbjct: 29 KIGKGSFGEVFKGIDNRT----QKVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYVTK 84
Query: 124 LLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHH 183
G L ++ Y+ GS LD L PL I + G+++LH
Sbjct: 85 YYGSYLKDTKLWIIMEYLGGGSALDLLE----PGPLDETQIATILREILKGLDYLHSEKK 140
Query: 184 IHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALR-GEITP 242
IHRDIK+AN+LL E K++DFG+ A + + + VGT +MAPE ++
Sbjct: 141 IHRDIKAANVLLSEHGEVKLADFGV--AGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDS 198
Query: 243 KSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSV 302
K+DI+S G+ +E+ G P E ++L I ++ T+E K + + V
Sbjct: 199 KADIWSLGITAIELARGEPPHSELHPMKVLFLIP---KNNPPTLEGNYSKPLKE----FV 251
Query: 303 EAMYSVASQCLHEKKNKRPDIKKV 326
EA CL+++ + RP K++
Sbjct: 252 EA-------CLNKEPSFRPTAKEL 268
>gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens]
Length = 443
Score = 102 bits (254), Expect = 5e-22
Identities = 79/264 (29%), Positives = 129/264 (48%), Gaps = 28/264 (10%)
Query: 67 KMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFD---QEIKVMAKCQHENLVE 123
K+G+G FG V+KG N T +K+ A+ I EE + + + QEI V+++C + +
Sbjct: 41 KIGKGSFGEVFKGIDNRT----QKVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYVTK 96
Query: 124 LLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHH 183
G L ++ Y+ GS LD L PL I + G+++LH
Sbjct: 97 YYGSYLKDTKLWIIMEYLGGGSALDLLE----PGPLDETQIATILREILKGLDYLHSEKK 152
Query: 184 IHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALR-GEITP 242
IHRDIK+AN+LL E K++DFG+ A + + + VGT +MAPE ++
Sbjct: 153 IHRDIKAANVLLSEHGEVKLADFGV--AGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDS 210
Query: 243 KSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSV 302
K+DI+S G+ +E+ G P E ++L I ++ T+E K + + V
Sbjct: 211 KADIWSLGITAIELARGEPPHSELHPMKVLFLIP---KNNPPTLEGNYSKPLKE----FV 263
Query: 303 EAMYSVASQCLHEKKNKRPDIKKV 326
EA CL+++ + RP K++
Sbjct: 264 EA-------CLNKEPSFRPTAKEL 280
>gi|21735550 mitogen-activated protein kinase kinase kinase 10 [Homo
sapiens]
Length = 954
Score = 101 bits (252), Expect = 8e-22
Identities = 77/204 (37%), Positives = 104/204 (50%), Gaps = 20/204 (9%)
Query: 68 MGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGF 127
+G GGFG VY+ VAVK + +Q QE ++ QH N++ L G
Sbjct: 104 IGVGGFGKVYRALWRGEEVAVKAARLDPEKDPAVTAEQVCQEARLFGALQHPNIIALRGA 163
Query: 128 SSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHH---I 184
+ LCLV Y G L R+ PP H+ A A G+N+LH + I
Sbjct: 164 CLNPPHLCLVMEY-ARGGALSRVLAGRRVPP---HVLVNWAVQVARGMNYLHNDAPVPII 219
Query: 185 HRDIKSANILLDEAF--------TAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEAL 236
HRD+KS NIL+ EA KI+DFGLAR K T M++ GT A+MAPE +
Sbjct: 220 HRDLKSINILILEAIENHNLADTVLKITDFGLAREWHK--TTKMSA--AGTYAWMAPEVI 275
Query: 237 RGEITPK-SDIYSFGVVLLEIITG 259
R + K SD++SFGV+L E++TG
Sbjct: 276 RLSLFSKSSDVWSFGVLLWELLTG 299
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.132 0.378
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 12,303,060
Number of Sequences: 37866
Number of extensions: 532415
Number of successful extensions: 3784
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 633
Number of HSP's successfully gapped in prelim test: 154
Number of HSP's that attempted gapping in prelim test: 1933
Number of HSP's gapped (non-prelim): 917
length of query: 336
length of database: 18,247,518
effective HSP length: 103
effective length of query: 233
effective length of database: 14,347,320
effective search space: 3342925560
effective search space used: 3342925560
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.