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Search of human proteins with 223671872
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|223671872 inhibitor of kappa light polypeptide gene enhancer
in B-cells, kinase gamma isoform c [Homo sapiens]
(320 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|223671872 inhibitor of kappa light polypeptide gene enhancer ... 638 0.0
gi|223671870 inhibitor of kappa light polypeptide gene enhancer ... 592 e-169
gi|4504631 inhibitor of kappa light polypeptide gene enhancer in... 592 e-169
gi|153792133 inhibitor of kappa light polypeptide gene enhancer ... 592 e-169
gi|56549111 optineurin [Homo sapiens] 73 3e-13
gi|56549109 optineurin [Homo sapiens] 73 3e-13
gi|20149572 optineurin [Homo sapiens] 73 3e-13
gi|56549107 optineurin [Homo sapiens] 73 3e-13
gi|115648142 centrosomal protein 164kDa [Homo sapiens] 62 5e-10
gi|239745299 PREDICTED: hypothetical protein [Homo sapiens] 58 1e-08
gi|16262452 cingulin [Homo sapiens] 58 1e-08
gi|21735548 centrosomal protein 2 [Homo sapiens] 57 3e-08
gi|169218106 PREDICTED: hypothetical protein, partial [Homo sapi... 57 3e-08
gi|145312241 differentially expressed in FDCP 6 homolog [Homo sa... 57 3e-08
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens] 56 4e-08
gi|122937382 Fas (TNFRSF6) binding factor 1 [Homo sapiens] 55 6e-08
gi|58530840 desmoplakin isoform I [Homo sapiens] 55 1e-07
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 55 1e-07
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 55 1e-07
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 55 1e-07
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 55 1e-07
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 55 1e-07
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 55 1e-07
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 55 1e-07
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 55 1e-07
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap... 54 1e-07
gi|4503593 epidermal growth factor receptor pathway substrate 15... 54 2e-07
gi|223634475 golgi autoantigen, golgin subfamily a, 6D [Homo sap... 54 2e-07
gi|51472437 PREDICTED: golgi autoantigen, golgin subfamily a, 6C... 54 2e-07
gi|64085252 hypothetical protein LOC145508 [Homo sapiens] 54 2e-07
>gi|223671872 inhibitor of kappa light polypeptide gene enhancer in
B-cells, kinase gamma isoform c [Homo sapiens]
Length = 320
Score = 638 bits (1646), Expect = 0.0
Identities = 320/320 (100%), Positives = 320/320 (100%)
Query: 1 MNRHLWKSQLCEMVQPSGGPAADQDVLGEESPLGKPAMLHLPSEQGAPETLQRCLEENQE 60
MNRHLWKSQLCEMVQPSGGPAADQDVLGEESPLGKPAMLHLPSEQGAPETLQRCLEENQE
Sbjct: 1 MNRHLWKSQLCEMVQPSGGPAADQDVLGEESPLGKPAMLHLPSEQGAPETLQRCLEENQE 60
Query: 61 LRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGLEKLDLKRQKEQ 120
LRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGLEKLDLKRQKEQ
Sbjct: 61 LRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGLEKLDLKRQKEQ 120
Query: 121 ALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQALEGRRKLAQLQ 180
ALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQALEGRRKLAQLQ
Sbjct: 121 ALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQALEGRRKLAQLQ 180
Query: 181 VAYHQLFQEYDNHIKSSVVGSERKRADIYKADFQAERQAREKLAEKKELLQEQLEQLQRE 240
VAYHQLFQEYDNHIKSSVVGSERKRADIYKADFQAERQAREKLAEKKELLQEQLEQLQRE
Sbjct: 181 VAYHQLFQEYDNHIKSSVVGSERKRADIYKADFQAERQAREKLAEKKELLQEQLEQLQRE 240
Query: 241 YSKLKASCQESARIEDMRKRHVEVSQAPLPPAPAYLSSPLALPSQRRSPPEEPPDFCCPK 300
YSKLKASCQESARIEDMRKRHVEVSQAPLPPAPAYLSSPLALPSQRRSPPEEPPDFCCPK
Sbjct: 241 YSKLKASCQESARIEDMRKRHVEVSQAPLPPAPAYLSSPLALPSQRRSPPEEPPDFCCPK 300
Query: 301 CQYQAPDMDTLQIHVMECIE 320
CQYQAPDMDTLQIHVMECIE
Sbjct: 301 CQYQAPDMDTLQIHVMECIE 320
>gi|223671870 inhibitor of kappa light polypeptide gene enhancer in
B-cells, kinase gamma isoform b [Homo sapiens]
Length = 487
Score = 592 bits (1525), Expect = e-169
Identities = 320/419 (76%), Positives = 320/419 (76%), Gaps = 99/419 (23%)
Query: 1 MNRHLWKSQLCEMVQPSGGPAADQDVLGEESPLGKPAMLHLPSEQGAPETLQRCLEENQE 60
MNRHLWKSQLCEMVQPSGGPAADQDVLGEESPLGKPAMLHLPSEQGAPETLQRCLEENQE
Sbjct: 69 MNRHLWKSQLCEMVQPSGGPAADQDVLGEESPLGKPAMLHLPSEQGAPETLQRCLEENQE 128
Query: 61 LRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGLEKLDLKRQKEQ 120
LRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGLEKLDLKRQKEQ
Sbjct: 129 LRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGLEKLDLKRQKEQ 188
Query: 121 ALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQALEGR------- 173
ALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQALEGR
Sbjct: 189 ALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQALEGRARAASEQ 248
Query: 174 --------------------------------------------RKLAQLQVAYHQLFQE 189
RKLAQLQVAYHQLFQE
Sbjct: 249 ARQLESEREALQQQHSVQVDQLRMQGQSVEAALRMERQAASEEKRKLAQLQVAYHQLFQE 308
Query: 190 YDNHIKSSVVGSERKR-------------------------------------------- 205
YDNHIKSSVVGSERKR
Sbjct: 309 YDNHIKSSVVGSERKRGMQLEDLKQQLQQAEEALVAKQEVIDKLKEEAEQHKIVMETVPV 368
Query: 206 ----ADIYKADFQAERQAREKLAEKKELLQEQLEQLQREYSKLKASCQESARIEDMRKRH 261
ADIYKADFQAERQAREKLAEKKELLQEQLEQLQREYSKLKASCQESARIEDMRKRH
Sbjct: 369 LKAQADIYKADFQAERQAREKLAEKKELLQEQLEQLQREYSKLKASCQESARIEDMRKRH 428
Query: 262 VEVSQAPLPPAPAYLSSPLALPSQRRSPPEEPPDFCCPKCQYQAPDMDTLQIHVMECIE 320
VEVSQAPLPPAPAYLSSPLALPSQRRSPPEEPPDFCCPKCQYQAPDMDTLQIHVMECIE
Sbjct: 429 VEVSQAPLPPAPAYLSSPLALPSQRRSPPEEPPDFCCPKCQYQAPDMDTLQIHVMECIE 487
>gi|4504631 inhibitor of kappa light polypeptide gene enhancer in
B-cells, kinase gamma isoform a [Homo sapiens]
Length = 419
Score = 592 bits (1525), Expect = e-169
Identities = 320/419 (76%), Positives = 320/419 (76%), Gaps = 99/419 (23%)
Query: 1 MNRHLWKSQLCEMVQPSGGPAADQDVLGEESPLGKPAMLHLPSEQGAPETLQRCLEENQE 60
MNRHLWKSQLCEMVQPSGGPAADQDVLGEESPLGKPAMLHLPSEQGAPETLQRCLEENQE
Sbjct: 1 MNRHLWKSQLCEMVQPSGGPAADQDVLGEESPLGKPAMLHLPSEQGAPETLQRCLEENQE 60
Query: 61 LRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGLEKLDLKRQKEQ 120
LRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGLEKLDLKRQKEQ
Sbjct: 61 LRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGLEKLDLKRQKEQ 120
Query: 121 ALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQALEGR------- 173
ALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQALEGR
Sbjct: 121 ALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQALEGRARAASEQ 180
Query: 174 --------------------------------------------RKLAQLQVAYHQLFQE 189
RKLAQLQVAYHQLFQE
Sbjct: 181 ARQLESEREALQQQHSVQVDQLRMQGQSVEAALRMERQAASEEKRKLAQLQVAYHQLFQE 240
Query: 190 YDNHIKSSVVGSERKR-------------------------------------------- 205
YDNHIKSSVVGSERKR
Sbjct: 241 YDNHIKSSVVGSERKRGMQLEDLKQQLQQAEEALVAKQEVIDKLKEEAEQHKIVMETVPV 300
Query: 206 ----ADIYKADFQAERQAREKLAEKKELLQEQLEQLQREYSKLKASCQESARIEDMRKRH 261
ADIYKADFQAERQAREKLAEKKELLQEQLEQLQREYSKLKASCQESARIEDMRKRH
Sbjct: 301 LKAQADIYKADFQAERQAREKLAEKKELLQEQLEQLQREYSKLKASCQESARIEDMRKRH 360
Query: 262 VEVSQAPLPPAPAYLSSPLALPSQRRSPPEEPPDFCCPKCQYQAPDMDTLQIHVMECIE 320
VEVSQAPLPPAPAYLSSPLALPSQRRSPPEEPPDFCCPKCQYQAPDMDTLQIHVMECIE
Sbjct: 361 VEVSQAPLPPAPAYLSSPLALPSQRRSPPEEPPDFCCPKCQYQAPDMDTLQIHVMECIE 419
>gi|153792133 inhibitor of kappa light polypeptide gene enhancer in
B-cells, kinase gamma isoform a [Homo sapiens]
Length = 419
Score = 592 bits (1525), Expect = e-169
Identities = 320/419 (76%), Positives = 320/419 (76%), Gaps = 99/419 (23%)
Query: 1 MNRHLWKSQLCEMVQPSGGPAADQDVLGEESPLGKPAMLHLPSEQGAPETLQRCLEENQE 60
MNRHLWKSQLCEMVQPSGGPAADQDVLGEESPLGKPAMLHLPSEQGAPETLQRCLEENQE
Sbjct: 1 MNRHLWKSQLCEMVQPSGGPAADQDVLGEESPLGKPAMLHLPSEQGAPETLQRCLEENQE 60
Query: 61 LRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGLEKLDLKRQKEQ 120
LRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGLEKLDLKRQKEQ
Sbjct: 61 LRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGLEKLDLKRQKEQ 120
Query: 121 ALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQALEGR------- 173
ALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQALEGR
Sbjct: 121 ALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQALEGRARAASEQ 180
Query: 174 --------------------------------------------RKLAQLQVAYHQLFQE 189
RKLAQLQVAYHQLFQE
Sbjct: 181 ARQLESEREALQQQHSVQVDQLRMQGQSVEAALRMERQAASEEKRKLAQLQVAYHQLFQE 240
Query: 190 YDNHIKSSVVGSERKR-------------------------------------------- 205
YDNHIKSSVVGSERKR
Sbjct: 241 YDNHIKSSVVGSERKRGMQLEDLKQQLQQAEEALVAKQEVIDKLKEEAEQHKIVMETVPV 300
Query: 206 ----ADIYKADFQAERQAREKLAEKKELLQEQLEQLQREYSKLKASCQESARIEDMRKRH 261
ADIYKADFQAERQAREKLAEKKELLQEQLEQLQREYSKLKASCQESARIEDMRKRH
Sbjct: 301 LKAQADIYKADFQAERQAREKLAEKKELLQEQLEQLQREYSKLKASCQESARIEDMRKRH 360
Query: 262 VEVSQAPLPPAPAYLSSPLALPSQRRSPPEEPPDFCCPKCQYQAPDMDTLQIHVMECIE 320
VEVSQAPLPPAPAYLSSPLALPSQRRSPPEEPPDFCCPKCQYQAPDMDTLQIHVMECIE
Sbjct: 361 VEVSQAPLPPAPAYLSSPLALPSQRRSPPEEPPDFCCPKCQYQAPDMDTLQIHVMECIE 419
>gi|56549111 optineurin [Homo sapiens]
Length = 577
Score = 73.2 bits (178), Expect = 3e-13
Identities = 75/265 (28%), Positives = 119/265 (44%), Gaps = 36/265 (13%)
Query: 55 LEENQELRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGLEKLDL 114
L E QEL ++ + E+ QA +EK L KL++
Sbjct: 348 LNEKQELVYTNKKLELQVESMLSEIKMEQAKTEDEKSKLTVLQMTHNKLLQ--------- 398
Query: 115 KRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQALEGRR 174
+ AL+ +E L R + + + +A + L +L+ ++ L A+K+ Q E ++
Sbjct: 399 --EHNNALKTIEELTRKESEKVD-----RAVLKELSEKLELAEKAL--ASKQLQMDEMKQ 449
Query: 175 KLAQLQVAYHQLFQEYDNHIKSSVVGSERKRADIYKADFQAERQAREKLAEKKELLQEQL 234
+A+ QE D + + R + ++Y +DF AER AREK+ E+KE L QL
Sbjct: 450 TIAK---------QEEDLETMTIL----RAQMEVYCSDFHAERAAREKIHEEKEQLALQL 496
Query: 235 EQLQREYSKLKASCQESARIEDMRKRHVEVSQAPLPPAPAYLSSPLALPSQRRSPPEEPP 294
L +E + ++S + +M+ RH ++ AYL A R P
Sbjct: 497 AVLLKENDAFEDGGRQS--LMEMQSRHG--ARTSDSDQQAYLVQRGAEDRDWRQQ-RNIP 551
Query: 295 DFCCPKCQYQAPDMDTLQIHVMECI 319
CPKC PD+DTLQIHVM+CI
Sbjct: 552 IHSCPKCGEVLPDIDTLQIHVMDCI 576
Score = 53.9 bits (128), Expect = 2e-07
Identities = 46/169 (27%), Positives = 76/169 (44%), Gaps = 21/169 (12%)
Query: 15 QPSGGPAADQDVLGEESPLGKPAMLHLPSEQGAPETL----QRCLEENQELRDAIRQSNQ 70
QP +D E + G P + H + PE L + L EN +L++A++ +NQ
Sbjct: 4 QPLSCLTEKEDSPSESTGNGPPHLAHPNLDTFTPEELLQQMKELLTENHQLKEAMKLNNQ 63
Query: 71 ILRERCEELLHFQASQREEKEF-----------LMCKFQEARKLVERLGLEKLDLKRQKE 119
++ R EEL + Q+EE++F LM E KL E LG K +R E
Sbjct: 64 AMKGRFEELSAWTEKQKEERQFFEIQSKEAKERLMALSHENEKLKEELGKLKGKSERSSE 123
Query: 120 QALREVEHLKRCQQQMAEDK-----ASVKAQVTSLLGELQESQSRLEAA 163
+ L R + + +D+ ++A+ LLG + E Q +L ++
Sbjct: 124 DPTDD-SRLPRAEAEQEKDQLRTQVVRLQAEKADLLGIVSELQLKLNSS 171
>gi|56549109 optineurin [Homo sapiens]
Length = 577
Score = 73.2 bits (178), Expect = 3e-13
Identities = 75/265 (28%), Positives = 119/265 (44%), Gaps = 36/265 (13%)
Query: 55 LEENQELRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGLEKLDL 114
L E QEL ++ + E+ QA +EK L KL++
Sbjct: 348 LNEKQELVYTNKKLELQVESMLSEIKMEQAKTEDEKSKLTVLQMTHNKLLQ--------- 398
Query: 115 KRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQALEGRR 174
+ AL+ +E L R + + + +A + L +L+ ++ L A+K+ Q E ++
Sbjct: 399 --EHNNALKTIEELTRKESEKVD-----RAVLKELSEKLELAEKAL--ASKQLQMDEMKQ 449
Query: 175 KLAQLQVAYHQLFQEYDNHIKSSVVGSERKRADIYKADFQAERQAREKLAEKKELLQEQL 234
+A+ QE D + + R + ++Y +DF AER AREK+ E+KE L QL
Sbjct: 450 TIAK---------QEEDLETMTIL----RAQMEVYCSDFHAERAAREKIHEEKEQLALQL 496
Query: 235 EQLQREYSKLKASCQESARIEDMRKRHVEVSQAPLPPAPAYLSSPLALPSQRRSPPEEPP 294
L +E + ++S + +M+ RH ++ AYL A R P
Sbjct: 497 AVLLKENDAFEDGGRQS--LMEMQSRHG--ARTSDSDQQAYLVQRGAEDRDWRQQ-RNIP 551
Query: 295 DFCCPKCQYQAPDMDTLQIHVMECI 319
CPKC PD+DTLQIHVM+CI
Sbjct: 552 IHSCPKCGEVLPDIDTLQIHVMDCI 576
Score = 53.9 bits (128), Expect = 2e-07
Identities = 46/169 (27%), Positives = 76/169 (44%), Gaps = 21/169 (12%)
Query: 15 QPSGGPAADQDVLGEESPLGKPAMLHLPSEQGAPETL----QRCLEENQELRDAIRQSNQ 70
QP +D E + G P + H + PE L + L EN +L++A++ +NQ
Sbjct: 4 QPLSCLTEKEDSPSESTGNGPPHLAHPNLDTFTPEELLQQMKELLTENHQLKEAMKLNNQ 63
Query: 71 ILRERCEELLHFQASQREEKEF-----------LMCKFQEARKLVERLGLEKLDLKRQKE 119
++ R EEL + Q+EE++F LM E KL E LG K +R E
Sbjct: 64 AMKGRFEELSAWTEKQKEERQFFEIQSKEAKERLMALSHENEKLKEELGKLKGKSERSSE 123
Query: 120 QALREVEHLKRCQQQMAEDK-----ASVKAQVTSLLGELQESQSRLEAA 163
+ L R + + +D+ ++A+ LLG + E Q +L ++
Sbjct: 124 DPTDD-SRLPRAEAEQEKDQLRTQVVRLQAEKADLLGIVSELQLKLNSS 171
>gi|20149572 optineurin [Homo sapiens]
Length = 577
Score = 73.2 bits (178), Expect = 3e-13
Identities = 75/265 (28%), Positives = 119/265 (44%), Gaps = 36/265 (13%)
Query: 55 LEENQELRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGLEKLDL 114
L E QEL ++ + E+ QA +EK L KL++
Sbjct: 348 LNEKQELVYTNKKLELQVESMLSEIKMEQAKTEDEKSKLTVLQMTHNKLLQ--------- 398
Query: 115 KRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQALEGRR 174
+ AL+ +E L R + + + +A + L +L+ ++ L A+K+ Q E ++
Sbjct: 399 --EHNNALKTIEELTRKESEKVD-----RAVLKELSEKLELAEKAL--ASKQLQMDEMKQ 449
Query: 175 KLAQLQVAYHQLFQEYDNHIKSSVVGSERKRADIYKADFQAERQAREKLAEKKELLQEQL 234
+A+ QE D + + R + ++Y +DF AER AREK+ E+KE L QL
Sbjct: 450 TIAK---------QEEDLETMTIL----RAQMEVYCSDFHAERAAREKIHEEKEQLALQL 496
Query: 235 EQLQREYSKLKASCQESARIEDMRKRHVEVSQAPLPPAPAYLSSPLALPSQRRSPPEEPP 294
L +E + ++S + +M+ RH ++ AYL A R P
Sbjct: 497 AVLLKENDAFEDGGRQS--LMEMQSRHG--ARTSDSDQQAYLVQRGAEDRDWRQQ-RNIP 551
Query: 295 DFCCPKCQYQAPDMDTLQIHVMECI 319
CPKC PD+DTLQIHVM+CI
Sbjct: 552 IHSCPKCGEVLPDIDTLQIHVMDCI 576
Score = 53.9 bits (128), Expect = 2e-07
Identities = 46/169 (27%), Positives = 76/169 (44%), Gaps = 21/169 (12%)
Query: 15 QPSGGPAADQDVLGEESPLGKPAMLHLPSEQGAPETL----QRCLEENQELRDAIRQSNQ 70
QP +D E + G P + H + PE L + L EN +L++A++ +NQ
Sbjct: 4 QPLSCLTEKEDSPSESTGNGPPHLAHPNLDTFTPEELLQQMKELLTENHQLKEAMKLNNQ 63
Query: 71 ILRERCEELLHFQASQREEKEF-----------LMCKFQEARKLVERLGLEKLDLKRQKE 119
++ R EEL + Q+EE++F LM E KL E LG K +R E
Sbjct: 64 AMKGRFEELSAWTEKQKEERQFFEIQSKEAKERLMALSHENEKLKEELGKLKGKSERSSE 123
Query: 120 QALREVEHLKRCQQQMAEDK-----ASVKAQVTSLLGELQESQSRLEAA 163
+ L R + + +D+ ++A+ LLG + E Q +L ++
Sbjct: 124 DPTDD-SRLPRAEAEQEKDQLRTQVVRLQAEKADLLGIVSELQLKLNSS 171
>gi|56549107 optineurin [Homo sapiens]
Length = 577
Score = 73.2 bits (178), Expect = 3e-13
Identities = 75/265 (28%), Positives = 119/265 (44%), Gaps = 36/265 (13%)
Query: 55 LEENQELRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGLEKLDL 114
L E QEL ++ + E+ QA +EK L KL++
Sbjct: 348 LNEKQELVYTNKKLELQVESMLSEIKMEQAKTEDEKSKLTVLQMTHNKLLQ--------- 398
Query: 115 KRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQALEGRR 174
+ AL+ +E L R + + + +A + L +L+ ++ L A+K+ Q E ++
Sbjct: 399 --EHNNALKTIEELTRKESEKVD-----RAVLKELSEKLELAEKAL--ASKQLQMDEMKQ 449
Query: 175 KLAQLQVAYHQLFQEYDNHIKSSVVGSERKRADIYKADFQAERQAREKLAEKKELLQEQL 234
+A+ QE D + + R + ++Y +DF AER AREK+ E+KE L QL
Sbjct: 450 TIAK---------QEEDLETMTIL----RAQMEVYCSDFHAERAAREKIHEEKEQLALQL 496
Query: 235 EQLQREYSKLKASCQESARIEDMRKRHVEVSQAPLPPAPAYLSSPLALPSQRRSPPEEPP 294
L +E + ++S + +M+ RH ++ AYL A R P
Sbjct: 497 AVLLKENDAFEDGGRQS--LMEMQSRHG--ARTSDSDQQAYLVQRGAEDRDWRQQ-RNIP 551
Query: 295 DFCCPKCQYQAPDMDTLQIHVMECI 319
CPKC PD+DTLQIHVM+CI
Sbjct: 552 IHSCPKCGEVLPDIDTLQIHVMDCI 576
Score = 53.9 bits (128), Expect = 2e-07
Identities = 46/169 (27%), Positives = 76/169 (44%), Gaps = 21/169 (12%)
Query: 15 QPSGGPAADQDVLGEESPLGKPAMLHLPSEQGAPETL----QRCLEENQELRDAIRQSNQ 70
QP +D E + G P + H + PE L + L EN +L++A++ +NQ
Sbjct: 4 QPLSCLTEKEDSPSESTGNGPPHLAHPNLDTFTPEELLQQMKELLTENHQLKEAMKLNNQ 63
Query: 71 ILRERCEELLHFQASQREEKEF-----------LMCKFQEARKLVERLGLEKLDLKRQKE 119
++ R EEL + Q+EE++F LM E KL E LG K +R E
Sbjct: 64 AMKGRFEELSAWTEKQKEERQFFEIQSKEAKERLMALSHENEKLKEELGKLKGKSERSSE 123
Query: 120 QALREVEHLKRCQQQMAEDK-----ASVKAQVTSLLGELQESQSRLEAA 163
+ L R + + +D+ ++A+ LLG + E Q +L ++
Sbjct: 124 DPTDD-SRLPRAEAEQEKDQLRTQVVRLQAEKADLLGIVSELQLKLNSS 171
>gi|115648142 centrosomal protein 164kDa [Homo sapiens]
Length = 1460
Score = 62.4 bits (150), Expect = 5e-10
Identities = 63/237 (26%), Positives = 119/237 (50%), Gaps = 26/237 (10%)
Query: 44 EQGAPETLQRCLEENQEL-RDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARK 102
++ + + L+ LE Q+ R ++ Q N+ + E+ +E +AS++ E+ L ++A +
Sbjct: 692 QEASLQKLREELESQQKAERASLEQKNRQMLEQLKE--EIEASEKSEQAALNAAKEKALQ 749
Query: 103 LVERLGLEKLDLKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEA 162
+ E+L+ +R++ A E EH ++ + +A + V+SL ++QE+Q + EA
Sbjct: 750 QLR----EQLEGERKEAVATLEKEHSAELERLCSSLEAKHREVVSSLQKKIQEAQQKEEA 805
Query: 163 ATKECQALEGRRKLAQLQVAYHQLFQEYD-----NHIKSSVVGSERKRAD---------I 208
++C G+ + Q +YH E++ + V G +R D +
Sbjct: 806 QLQKCL---GQVEHRVHQKSYHVAGYEHELSSLLREKRQEVEGEHERRLDKMKEEHQQVM 862
Query: 209 YKADFQAERQAREKLAEKKELLQEQLEQLQREYSK-LKASCQES-ARIEDMRKRHVE 263
KA Q E + R++ AE L +LE+LQR + + L+ QE R+ED+R+RH E
Sbjct: 863 AKAREQYEAEERKQRAELLGHLTGELERLQRAHERELETVRQEQHKRLEDLRRRHRE 919
Score = 49.7 bits (117), Expect = 3e-06
Identities = 65/261 (24%), Positives = 117/261 (44%), Gaps = 26/261 (9%)
Query: 12 EMVQPSGGPAADQDVLGEESPLGKPAMLHLPSEQGAPETLQRCLEENQE-LRDAIRQSNQ 70
E V S P +V E P+ P L + + E + + LE++Q L ++ ++ Q
Sbjct: 561 EKVAVSPTPPVSPEVRSTE-PVAPPEQLSEAALKAMEEAVAQVLEQDQRHLLESKQEKMQ 619
Query: 71 ILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGLEKLDLKRQKEQALREVEHLKR 130
LRE+ Q EE+E L Q+ + L E+L ++E+A E +R
Sbjct: 620 QLREKL--------CQEEEEEILRLHQQKEQSLSSLR--ERLQKAIEEEEARMREEESQR 669
Query: 131 CQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQALEGRRKLAQLQVAYHQLFQEY 190
A+ ++S +A + E + S +L + Q E A L+ Q+ ++
Sbjct: 670 LSWLRAQVQSSTQADEDQIRAEQEASLQKLREELESQQKAE----RASLEQKNRQMLEQL 725
Query: 191 DNHIKSSVVGSERKRADIYKADFQAERQAREKL-AEKKE----LLQEQLEQLQREYSKLK 245
I++S + ++A + A +A +Q RE+L E+KE L +E +L+R S L+
Sbjct: 726 KEEIEAS---EKSEQAALNAAKEKALQQLREQLEGERKEAVATLEKEHSAELERLCSSLE 782
Query: 246 ASCQESARIEDMRKRHVEVSQ 266
A +E + ++K+ E Q
Sbjct: 783 AKHREV--VSSLQKKIQEAQQ 801
Score = 49.7 bits (117), Expect = 3e-06
Identities = 62/227 (27%), Positives = 108/227 (47%), Gaps = 34/227 (14%)
Query: 51 LQRCLEENQELRDAIRQSNQI--LRERCEELLHFQAS----QREEKEFLMCKFQEARKLV 104
L + EE+Q++ R+ + ++R E L H QR + L QE K +
Sbjct: 851 LDKMKEEHQQVMAKAREQYEAEERKQRAELLGHLTGELERLQRAHERELETVRQEQHKRL 910
Query: 105 ERLGLEKLDLKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAAT 164
E DL+R+ + R+++ L+ + A+D VKA++ L E+QE +R E
Sbjct: 911 E-------DLRRRHREQERKLQDLELDLETRAKD---VKARLALL--EVQEETARREKQ- 957
Query: 165 KECQALEGRRKLA---QLQVAYHQLFQEYDNHIKSSVVGSERKRADIYKADFQAERQARE 221
Q L+ +R++A + A HQ +E + +++ R + E QAR+
Sbjct: 958 ---QLLDVQRQVALKSEEATATHQQLEEAQKEHTHLLQSNQQLR------EILDELQARK 1008
Query: 222 -KLAEKKELLQEQLEQLQREYSKLKASCQESARIEDMRKRHVEVSQA 267
KL + +LLQ Q +QLQ+ +S L+A Q+ + +R+ VE + A
Sbjct: 1009 LKLESQVDLLQAQSQQLQKHFSSLEAEAQKKQHL--LREVTVEENNA 1053
>gi|239745299 PREDICTED: hypothetical protein [Homo sapiens]
Length = 523
Score = 57.8 bits (138), Expect = 1e-08
Identities = 62/243 (25%), Positives = 112/243 (46%), Gaps = 16/243 (6%)
Query: 7 KSQLCEMV--QPSGGPAADQDVLGEESPLGKPAMLHLPSEQGAPETLQRCLEENQELRDA 64
K+Q E + +P GP+ + + E + L K + LQ +E NQ L
Sbjct: 141 KNQTAEPLAPEPPAGPSKVEQLQDETNHLRKEL-------ESVGRQLQAEVENNQMLSLL 193
Query: 65 IRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGLEKLDLKRQKEQALRE 124
R+ + LRE+ E L + RE++E L + + R+ ERL ++ L Q+E+
Sbjct: 194 NRRQEERLREQEERLREQEERLREQEERLCEQEERLREQEERLREQEERLCEQEERLREH 253
Query: 125 VEHLKRCQQQMAEDKASVKAQVTSLLGE---LQESQSRL-EAATKECQALEGRRKLAQLQ 180
E L ++++ E + ++ Q L + L E + RL E + C+ E R+ +
Sbjct: 254 EERLCEQEERLCEQEERLREQEERLHEQEERLCEQEERLREQEERLCEQEERLREQEERL 313
Query: 181 VAYHQLFQEYDNHI--KSSVVGSERKRADIYKADFQAERQ-AREKLAEKKELLQEQLEQL 237
+ +E + + + + G ER ++ K Q RQ +E+L E++ LL+E E L
Sbjct: 314 CEQEERLREQEERLCEQEKLPGQERLLEEVEKLLEQERRQEEQERLLERERLLEEVEELL 373
Query: 238 QRE 240
++E
Sbjct: 374 EQE 376
Score = 46.6 bits (109), Expect = 3e-05
Identities = 49/215 (22%), Positives = 93/215 (43%), Gaps = 39/215 (18%)
Query: 50 TLQRCLEENQELRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGL 109
TL+ + QEL A+ S+ I+ + E + + +EEK+ + LV++LG
Sbjct: 83 TLEDLESQYQELAVALDSSSAIISQLTENINSLVRTSKEEKKHEI-------HLVQKLGR 135
Query: 110 EKLDLKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQA 169
LK Q + L A + + ++V L E + LE+ ++ QA
Sbjct: 136 SLFKLKNQTAEPL-------------APEPPAGPSKVEQLQDETNHLRKELESVGRQLQA 182
Query: 170 -LEGRRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRADIYKADFQAERQAREKLAEKKE 228
+E + L+ L + +E + ++ ER R + E+L E++E
Sbjct: 183 EVENNQMLSLLNRRQEERLREQEERLREQ---EERLR------------EQEERLCEQEE 227
Query: 229 LLQEQLEQLQREYSKLKASCQESARIEDMRKRHVE 263
L+EQ E+L+ + +L C++ R+ + +R E
Sbjct: 228 RLREQEERLREQEERL---CEQEERLREHEERLCE 259
Score = 43.5 bits (101), Expect = 2e-04
Identities = 54/252 (21%), Positives = 98/252 (38%), Gaps = 46/252 (18%)
Query: 42 PSEQGAPETLQRCLEENQELRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEAR 101
P P +++ +E LR + + L+ E R ++E L + + R
Sbjct: 150 PEPPAGPSKVEQLQDETNHLRKELESVGRQLQAEVENNQMLSLLNRRQEERLREQEERLR 209
Query: 102 KLVERLGLEKLDLKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRL- 160
+ ERL ++ L Q+E+ + E L+ ++++ E + L+E + RL
Sbjct: 210 EQEERLREQEERLCEQEERLREQEERLREQEERLCEQEE-----------RLREHEERLC 258
Query: 161 EAATKECQALEGRRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRADIYKADFQAERQAR 220
E + C+ E R+ QE H + + + +R R+
Sbjct: 259 EQEERLCEQEERLRE------------QEERLHEQEERLCEQEERL----------REQE 296
Query: 221 EKLAEKKELLQEQLEQLQREYSKLKASCQESARIEDMRKRHVEVSQAPLPPAPAYLSSPL 280
E+L E++E L+EQ E+L C++ R+ + +R E Q LP L
Sbjct: 297 ERLCEQEERLREQEERL----------CEQEERLREQEERLCE--QEKLPGQERLLEEVE 344
Query: 281 ALPSQRRSPPEE 292
L Q R E+
Sbjct: 345 KLLEQERRQEEQ 356
>gi|16262452 cingulin [Homo sapiens]
Length = 1203
Score = 57.8 bits (138), Expect = 1e-08
Identities = 55/209 (26%), Positives = 101/209 (48%), Gaps = 15/209 (7%)
Query: 49 ETLQRCLEENQELRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLG 108
+ LQR E Q+L +A+ S + + S K L + +EA++ + RLG
Sbjct: 765 DKLQRLEAEKQQLEEALNASQEE-----------EGSLAAAKRALEARLEEAQRGLARLG 813
Query: 109 LEKLDLKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQ 168
E+ L R E+ ++ E L+R + ++ E K + V L EL++ + A ++ Q
Sbjct: 814 QEQQTLNRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLNKELEKIGEDSKQALQQLQ 873
Query: 169 A-LEGRRKLAQLQVAYHQ-LFQEYDNHIKSSVVGSERKRADI--YKADFQAERQAREKLA 224
A LE ++ A+ +VA Q +++ + + + G R + +I + QA + R+
Sbjct: 874 AQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQALQASQAERDTAR 933
Query: 225 EKKELLQEQLEQLQREYSKLKASCQESAR 253
KELL ++L+ L++E K S + AR
Sbjct: 934 LDKELLAQRLQGLEQEAENKKRSQDDRAR 962
Score = 45.4 bits (106), Expect = 7e-05
Identities = 57/233 (24%), Positives = 107/233 (45%), Gaps = 26/233 (11%)
Query: 47 APETLQRCLEE-----NQELRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEAR 101
A + LQ LE+ +E+ DA RQ+ E E+ + ++E + L Q ++
Sbjct: 868 ALQQLQAQLEDYKEKARREVADAQRQAKDWASE-AEKTSGGLSRLQDEIQRLRQALQASQ 926
Query: 102 KLVERLGLEKLDLKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLE 161
+ L+K L ++ + +E E+ KR Q A ++ +V+ L EL E ++ +E
Sbjct: 927 AERDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQLKGLEEKVSRLETELDEEKNTVE 986
Query: 162 AATKECQALEGRRKLAQLQVAYHQLFQEYD--NHIKSSVVGSERKRADIY-----KADFQ 214
T GR ++ QL+ +L QE ++ + ER+ D+ FQ
Sbjct: 987 LLTDRVN--RGRDQVDQLRT---ELMQERSARQDLECDKISLERQNKDLKTRLASSEGFQ 1041
Query: 215 AERQAREKLAEKKELLQEQLEQLQREYSKLKASCQE--------SARIEDMRK 259
+ +L + +LLQE+L+ +RE + L+++ ++ S +IED R+
Sbjct: 1042 KPSASLSQLESQNQLLQERLQAEEREKTVLQSTNRKLERKVKELSIQIEDERQ 1094
Score = 45.1 bits (105), Expect = 9e-05
Identities = 50/208 (24%), Positives = 91/208 (43%), Gaps = 14/208 (6%)
Query: 56 EENQELRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGLEKLDLK 115
E + E ++R+ ++ E+ + L+ + + + E + VE L KLD +
Sbjct: 324 EGSSESETSVRRKVSLVLEKMQPLVMVSSGSTKA----VAGQGELTRKVEELQ-RKLDEE 378
Query: 116 RQKEQALREVE-HLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQALEGRR 174
+K Q L + L+R ++ E+ + ++ + GE Q+S L+ + E R
Sbjct: 379 VKKRQKLEPSQVGLERQLEEKTEECSRLQELLERRKGEAQQSNKELQNMKRLLDQGEDLR 438
Query: 175 KLAQLQVAYHQLFQEYDNHIKSSVVGSERKRADIYKADFQAERQAREKLAEKKELLQEQL 234
+ QV E N +K V G E + + K D R+ E++ E K+ ++EQL
Sbjct: 439 HGLETQV------MELQNKLKH-VQGPEPAKEVLLK-DLLETRELLEEVLEGKQRVEEQL 490
Query: 235 EQLQREYSKLKASCQESARIEDMRKRHV 262
+RE + LK + +E D HV
Sbjct: 491 RLRERELTALKGALKEEVASRDQEVEHV 518
Score = 35.8 bits (81), Expect = 0.052
Identities = 51/230 (22%), Positives = 103/230 (44%), Gaps = 21/230 (9%)
Query: 49 ETLQRCLEENQELRDAIRQ----SNQILRERCEELLHFQASQREEKEFLMCKFQEARKLV 104
E LQR LE+ + RQ ++LR + EEL QA ++ ++ + R+L
Sbjct: 608 EVLQRELEQARASAGDTRQVEVLKKELLRTQ-EELKELQAERQSQE---VAGRHRDRELE 663
Query: 105 ERLGLEKLDLKRQKEQALREVEHLKRCQQ--QMAEDKASVKAQVTSLLGELQESQSRLEA 162
++L + +++ R +E + ++ K QQ Q E+ + K + L + ++ +E
Sbjct: 664 KQLAVLRVEADRGRELEEQNLQLQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAAVET 723
Query: 163 ATKECQAL--EGRRKLAQLQVAYHQL------FQEYDNHIKSSVVGSERKRADIYKADFQ 214
+E Q E RR++ L+ + + + ++ + E ++ + +A
Sbjct: 724 TLRETQEENDEFRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEA-LN 782
Query: 215 AERQAREKLAEKKELLQEQLEQLQREYSKLKASCQESARI--EDMRKRHV 262
A ++ LA K L+ +LE+ QR ++L Q R E+ ++R V
Sbjct: 783 ASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTLNRALEEEGKQREV 832
Score = 31.6 bits (70), Expect = 0.98
Identities = 30/126 (23%), Positives = 60/126 (47%), Gaps = 19/126 (15%)
Query: 49 ETLQRCLEENQELRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLG 108
+ LQ L+ + + ++ +N+ L + +EL + Q E++ Q ++L
Sbjct: 1055 QLLQERLQAEEREKTVLQSTNRKLERKVKEL----SIQIEDER------QHVNDQKDQLS 1104
Query: 109 LEKLDLKRQKEQALREVEH---LKRCQQQMAEDKASVKAQVTSLLGELQE------SQSR 159
L LKRQ ++A E+E L++ Q+ E++ V Q+ + + L++ S+S
Sbjct: 1105 LRVKALKRQVDEAEEEIERLDGLRKKAQREVEEQHEVNEQLQARIKSLEKDSWRKASRSA 1164
Query: 160 LEAATK 165
E+A K
Sbjct: 1165 AESALK 1170
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 56.6 bits (135), Expect = 3e-08
Identities = 66/252 (26%), Positives = 107/252 (42%), Gaps = 17/252 (6%)
Query: 39 LHLPSEQGAPETLQRCLEENQELRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQ 98
L L ++ E Q + E QEL+D + Q Q L + E + + +E L + Q
Sbjct: 1729 LILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQ 1788
Query: 99 EARKLVERLGLEKLDLKRQKEQALR-------EVEHLKRCQQQMAEDKASVKAQVTSLLG 151
EAR+ E L++ L+ Q ++A R E+E L++ QQQ + VK + +L G
Sbjct: 1789 EAREQGE---LKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQG 1845
Query: 152 ELQESQSRLEAATKECQ-ALEGRRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRADIYK 210
L+++ L+ E Q E R+L + + Q + + S + +
Sbjct: 1846 ALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLA 1905
Query: 211 ADFQAERQAREKLAEKKEL----LQEQ--LEQLQREYSKLKASCQESARIEDMRKRHVEV 264
Q QA+E E + L LQ Q L++ +E L+A Q S E+ + E
Sbjct: 1906 LQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEA 1965
Query: 265 SQAPLPPAPAYL 276
Q L A A L
Sbjct: 1966 LQEALGKAHAAL 1977
Score = 48.9 bits (115), Expect = 6e-06
Identities = 53/240 (22%), Positives = 110/240 (45%), Gaps = 22/240 (9%)
Query: 44 EQGAPETLQRCLEENQELRDAIRQSNQILRERCEELL-HFQASQREEKEFLMCKFQEARK 102
++ A E L L++ + D ++ Q L E+C +L H + +E ++ L + ++ R+
Sbjct: 1454 QKAALELLSLDLKKRNQEVDLQQEQIQEL-EKCRSVLEHLPMAVQEREQKLTVQREQIRE 1512
Query: 103 LVERLGLEKLDLKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEA 162
L + ++ L+ Q + L + + + Q+ +D + L EL+E+ ++E
Sbjct: 1513 LEKDRETQRNVLEHQLLE-LEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMEC 1571
Query: 163 ATKECQALEGRRKLAQLQVAY-------------HQLFQEYDNHIKSSVVGSERKRADIY 209
K + LEG+R+ ++ + + Q Q +D S+V+ E + D
Sbjct: 1572 QQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERD-- 1629
Query: 210 KADFQAERQAREKLAEKKELLQEQLEQLQREYSKLKASCQESARIEDMRKRHVEVSQAPL 269
+ +++R+ E+L +KE L + LE+ +E K Q +ED R R ++ + L
Sbjct: 1630 -QEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQV---LEDQRTRQTKILEEDL 1685
Score = 47.4 bits (111), Expect = 2e-05
Identities = 47/158 (29%), Positives = 78/158 (49%), Gaps = 17/158 (10%)
Query: 99 EARKLVERLGLEKLDLKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQES-- 156
+ +KL ERL D + +K Q E++ L+R Q E+K+ + + SL EL E
Sbjct: 1265 QVQKLEERL----TDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHE 1320
Query: 157 -----QSRLEAATKECQALEGRRKLAQLQVAYHQLFQEYDNHIKSSVV--GSERKRADIY 209
QSRL A + +G R+L LQ A L + + H++++VV ++ A I
Sbjct: 1321 TMASLQSRLRRAELQRMEAQGEREL--LQAAKENLTAQVE-HLQAAVVEARAQASAAGIL 1377
Query: 210 KADFQAERQAREKLAEKKELLQEQLEQLQREYSKLKAS 247
+ D + R A + E+ E +E+ + LQ E +LK +
Sbjct: 1378 EEDLRTARSALKLKNEEVESERERAQALQ-EQGELKVA 1414
Score = 47.0 bits (110), Expect = 2e-05
Identities = 56/189 (29%), Positives = 89/189 (47%), Gaps = 26/189 (13%)
Query: 72 LRERCEELLHFQASQREEK---EFLMCKFQ-EARKLVERLGLEKLDLKRQKEQALREVEH 127
L+E+ E+ QA + EE+ E +C+ Q E K ER+ L + L+ QKE A +
Sbjct: 891 LKEQQTEMEAIQAQREEERTQAESALCQMQLETEK--ERVSLLETLLQTQKELADAS-QQ 947
Query: 128 LKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQALEGRRKLAQLQVAYHQLF 187
L+R +Q M K + L +LQE+Q L+ A A + R LA LQ L
Sbjct: 948 LERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEA-----ARQHRDDLAALQEESSSLL 1002
Query: 188 QE------YDNHIKSSVVGSERKRADIYKADFQAERQAREKLAEKKELLQEQLEQLQREY 241
Q+ +KS +V + + + E++ +EKL E +E + Q ++L+RE
Sbjct: 1003 QDKMDLQKQVEDLKSQLVAQDDSQRLV-------EQEVQEKLRETQEYNRIQ-KELEREK 1054
Query: 242 SKLKASCQE 250
+ L S E
Sbjct: 1055 ASLTLSLME 1063
Score = 47.0 bits (110), Expect = 2e-05
Identities = 61/237 (25%), Positives = 109/237 (45%), Gaps = 24/237 (10%)
Query: 24 QDVLGE---ESPLGKPAMLHLPSEQGAPETLQRCLEENQELRDAIRQSNQILRERCEELL 80
++VLG+ ES + A+L L +Q E Q E + L+D+ Q+ +L+ER +EL
Sbjct: 1886 EEVLGDLRAESREQEKALLAL--QQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELE 1943
Query: 81 HFQASQREEKEFLMCKFQEARKLVERLGLEKLDLKRQKEQALREVEHLKRCQQQMAEDKA 140
+A + + A L E LG L+ +++ L + E + + A +A
Sbjct: 1944 ALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQA 2003
Query: 141 SVKA------QVTSLL----GELQESQSRLEAATKEC-QALEGRRKLAQLQVAYHQLFQE 189
S+ A Q+ L GE+Q+ R + ++ QAL R + + Q QL ++
Sbjct: 2004 SLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEK 2063
Query: 190 ------YDNHIKSSV-VGSERKRADIYKADFQAERQAREKLAEKKELLQEQLEQLQR 239
+N I+ +G ER+ +I + Q+ R+ + LA+K++ + E E QR
Sbjct: 2064 SLAQRVQENMIQEKQNLGQEREEEEI-RGLHQSVRELQLTLAQKEQEILELRETQQR 2119
Score = 45.8 bits (107), Expect = 5e-05
Identities = 53/229 (23%), Positives = 102/229 (44%), Gaps = 17/229 (7%)
Query: 49 ETLQRCLEENQELRDAI-----RQSNQI-----LRERCEELLHFQASQREEKEFLMCKFQ 98
E L + E + L++ + +QS + LRE E R+E+ +
Sbjct: 512 EELHLAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALA 571
Query: 99 EARKLVERLGLEKLDLKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQS 158
A + + L + LK + L + +A DK + Q+ L E Q S
Sbjct: 572 RAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCS 631
Query: 159 RLEAATKECQALEGRRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRADIYKADFQAERQ 218
R+EAA + AL+ LA+ + L+ E + H+++ + +E A++ +AD + ++
Sbjct: 632 RMEAAEQARNALQ--VDLAEAEKRREALW-EKNTHLEAQLQKAEEAGAEL-QADLRDIQE 687
Query: 219 AREKLAEKKELLQEQLEQLQREYSKLKASCQESARIEDMRKRHVEVSQA 267
+E++ +K L E Q + ++L+ QE+ R E++ R V+ +A
Sbjct: 688 EKEEIQKK---LSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEA 733
Score = 43.1 bits (100), Expect = 3e-04
Identities = 66/264 (25%), Positives = 115/264 (43%), Gaps = 39/264 (14%)
Query: 44 EQGAPETLQRCLEENQ-ELRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARK 102
EQ LQ L+E Q EL++A RQ L A+ +EE L+ + +K
Sbjct: 962 EQETTGILQTQLQEAQRELKEAARQHRDDL-----------AALQEESSSLLQDKMDLQK 1010
Query: 103 LVERLGLEKLD-------LKRQKEQALREVEHLKRCQQQMAEDKASV------KAQVTSL 149
VE L + + ++++ ++ LRE + R Q+++ +KAS+ K Q +
Sbjct: 1011 QVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLV 1070
Query: 150 LGELQE-SQSRLEAATKECQALEGRRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRADI 208
L E Q L A ++ Q +G +K Q+ +L ++ ++ + E + +
Sbjct: 1071 LQEADSIRQQELSALRQDMQEAQGEQKELSAQM---ELLRQEVKEKEADFLAQEAQLLEE 1127
Query: 209 YKADFQAERQAREKL-AEKKELLQEQLEQLQREYSKLKASCQESARIEDMRKRHVEVSQA 267
+A E+Q R L A++ + Q QL +L+ S+L+A E ++ +QA
Sbjct: 1128 LEASHITEQQLRASLWAQEAKAAQLQL-RLRSTESQLEALAAE--------QQPGNQAQA 1178
Query: 268 PLPPAPAYLSSPLALPSQRRSPPE 291
A Y + AL S S PE
Sbjct: 1179 QAQLASLYSALQQALGSVCESRPE 1202
Score = 42.0 bits (97), Expect = 7e-04
Identities = 60/216 (27%), Positives = 98/216 (45%), Gaps = 44/216 (20%)
Query: 56 EENQELRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKF--------QEARKLVERL 107
+ QE A RQ Q +E L +A+ +E L K+ QE K +E L
Sbjct: 821 QAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESL 880
Query: 108 GLEKLDLK-RQKE--------QALREVEHLKR----CQQQMAEDKASVKAQVTSLLGELQ 154
EK++L+ R KE QA RE E + CQ Q+ +K V SLL L
Sbjct: 881 EREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERV-----SLLETLL 935
Query: 155 ESQSRLEAATKECQALEGRRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRADIYKADFQ 214
++Q L A+++ + L K+ +L+ QE +++ + ++R+ +
Sbjct: 936 QTQKELADASQQLERLRQDMKVQKLKE------QETTGILQTQLQEAQRELK-------E 982
Query: 215 AERQAREKLA----EKKELLQEQLEQLQREYSKLKA 246
A RQ R+ LA E LLQ++++ LQ++ LK+
Sbjct: 983 AARQHRDDLAALQEESSSLLQDKMD-LQKQVEDLKS 1017
Score = 41.6 bits (96), Expect = 0.001
Identities = 52/219 (23%), Positives = 95/219 (43%), Gaps = 17/219 (7%)
Query: 49 ETLQRCLEENQELRDAIRQSNQILRERCEELL----HFQASQREEKEFLMCKFQEARKLV 104
E LQ+ EE ++ + + Q LR EL Q + E++E L +E +L
Sbjct: 466 ELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQ 525
Query: 105 ERL-GLEK---------LDLKRQKEQALREVEHLKRCQQQMAEDKASVK---AQVTSLLG 151
E L GLE + L+ E + E E L++ Q ++ A + A+++S
Sbjct: 526 EMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSEN 585
Query: 152 ELQESQSRLEAATKECQALEGRRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRADIYKA 211
L+ + L AA + AL L ++ + L E +N S + + + + +
Sbjct: 586 TLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQV 645
Query: 212 DFQAERQAREKLAEKKELLQEQLEQLQREYSKLKASCQE 250
D + RE L EK L+ QL++ + ++L+A ++
Sbjct: 646 DLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRD 684
Score = 41.6 bits (96), Expect = 0.001
Identities = 47/218 (21%), Positives = 105/218 (48%), Gaps = 16/218 (7%)
Query: 56 EENQELRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGLEKLDLK 115
E +LRD I++ + ++++ E H Q + + E L + + +++ R EK L
Sbjct: 677 ELQADLRD-IQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALV 735
Query: 116 RQKEQALREVEHLKRCQQQMAED---KASVKAQVTSLLGELQESQSRLEAA----TKECQ 168
R+K ++ ++R +Q +AE +S K + S L E Q+ S +E + Q
Sbjct: 736 REKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQ 795
Query: 169 ALEGRRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRADIYKADFQAERQAREKLAEKKE 228
+ +++ Q +V +L E D +E++R + QAE++ + L ++K
Sbjct: 796 TVTQAKEVIQGEVRCLKL--ELDTERSQ----AEQERDAAARQLAQAEQEGKTALEQQKA 849
Query: 229 LLQEQLEQLQREYSKLKASCQE--SARIEDMRKRHVEV 264
++++ QL+ ++ K ++ Q+ + +E + + +E+
Sbjct: 850 AHEKEVNQLREKWEKERSWHQQELAKALESLEREKMEL 887
Score = 38.9 bits (89), Expect = 0.006
Identities = 57/268 (21%), Positives = 101/268 (37%), Gaps = 59/268 (22%)
Query: 1 MNRHLWKSQLCEMVQPSGGPAADQDVLGEESPLGKPAMLHLPSEQGAPET----LQRCLE 56
+++ LWK+Q +DVL ++ + + +E+ T LQR L
Sbjct: 1248 LHQDLWKTQ------------QTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLS 1295
Query: 57 ENQELRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGLEKLDLKR 116
+NQE + L EL AS + L + +L+R
Sbjct: 1296 QNQEEKSKWEGKQNSLESELMELHETMASLQSR-------------------LRRAELQR 1336
Query: 117 QKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQALEGRRKL 176
+ Q RE+ + K ++ AQV L + E++++ AA + L R
Sbjct: 1337 MEAQGEREL---------LQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSA 1387
Query: 177 AQLQVAYHQLFQEYDNHIKSSVVGSERKRADIYKADFQAERQAREKLAEKKELLQEQLEQ 236
+L K+ V SER+RA + + + + L E LL + L +
Sbjct: 1388 LKL---------------KNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAE 1432
Query: 237 LQREYSKLKASCQESARIEDMRKRHVEV 264
+ E L+ QE + +M+K +E+
Sbjct: 1433 REEEVETLRGQIQELEKQREMQKAALEL 1460
Score = 38.9 bits (89), Expect = 0.006
Identities = 57/249 (22%), Positives = 105/249 (42%), Gaps = 36/249 (14%)
Query: 53 RCLEENQE-----LRDAIRQ---SNQILRERCEELLHFQASQREEKEFLMCKFQEARKLV 104
+ LEE+ E LR+ R+ Q+++ER EE +QR E + ++ K V
Sbjct: 1679 KILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEV 1738
Query: 105 ERLGLEKLDLKRQKEQALREVEHLKR------------------CQQQMAEDKASVKAQV 146
E +L+ K+Q ++++ L R QQQ+ E + + +
Sbjct: 1739 ECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKE 1798
Query: 147 TSLLGELQESQSRLEAATKECQALEGRRKLAQLQ-VAYHQLFQEYDNHIKSSVVGSERKR 205
SL +L E+Q L +E +AL+ ++ AQ Q + ++ + + + +
Sbjct: 1799 QSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERH 1858
Query: 206 ADIYKADFQAERQAREKLAE--KKELLQEQLEQLQ---REYSK----LKASCQESARIED 256
++ QA R E E + + L+E L L+ RE K L+ C E A+ +
Sbjct: 1859 GELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHE 1918
Query: 257 MRKRHVEVS 265
+ R ++ S
Sbjct: 1919 VETRALQDS 1927
Score = 36.6 bits (83), Expect = 0.031
Identities = 52/233 (22%), Positives = 94/233 (40%), Gaps = 35/233 (15%)
Query: 56 EENQELRDAIRQSNQILRERCEELLHF-QASQREEKEFLMCKFQEARKLVERLGLEKLDL 114
EE + L ++R+ L ++ +E+L + QR E L + + + L L+ L+
Sbjct: 2087 EEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSLEP 2146
Query: 115 KRQKE-----QALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAAT----K 165
+ Q+E ALR+ E + ++ A+D A AQ + + LQE L+A+
Sbjct: 2147 RLQRELERLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDS 2206
Query: 166 ECQALEGRRKLAQLQVAYHQLFQ-------EYDNHIKSSVVGSERKRADIYKADFQAERQ 218
E Q L+ +L + + +L E + + V E + + E+Q
Sbjct: 2207 EQQRLQDELELTRRALEKERLHSPGATSTAELGSRGEQGVQLGEVSGVEAEPSPDGMEKQ 2266
Query: 219 A------------------REKLAEKKELLQEQLEQLQREYSKLKASCQESAR 253
+ R +L L+ LEQ++RE KLK +A+
Sbjct: 2267 SWRQRLEHLQQAVARLEIDRSRLQRHNVQLRSTLEQVERERRKLKREAMRAAQ 2319
Score = 34.3 bits (77), Expect = 0.15
Identities = 61/281 (21%), Positives = 108/281 (38%), Gaps = 44/281 (15%)
Query: 6 WKSQLCEMVQPSGGPAADQDVLGEESPLGKPAMLHLPSEQGAPETLQRCLEENQELRDAI 65
W +L + ++ +GGP P E E L R LEE Q+ +++
Sbjct: 69 WCQELEKRLEATGGPI--------------PQRWENVEEPNLDELLVR-LEEEQQRCESL 113
Query: 66 RQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGLE--------KLDLKRQ 117
+ N LR E+ + RE+ E L + AR + R + K LK +
Sbjct: 114 AEVNTQLRLHMEKADVVNKALREDVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGE 173
Query: 118 KEQAL---REV----EHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQ-- 168
+ L REV H + D +KA+ L G L RL + +
Sbjct: 174 HGRLLSLWREVVTFRRHFLEMKSATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPN 233
Query: 169 ---ALEGRRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRADIYKADFQAERQAREKLAE 225
++GR L + E + H +S + + + D+ KA+ Q +++ E
Sbjct: 234 GSGRMDGREPAQLLLLLAKTQELEKEAHERSQELIQLKSQGDLEKAELQ------DRVTE 287
Query: 226 KKELLQEQLEQLQREYSKLKASCQESARIEDMRKRHVEVSQ 266
LL + +Q +Y K+ + +E+ +E + H E+ +
Sbjct: 288 LSALLTQSQKQ-NEDYEKMIKALRET--VEILETNHTELME 325
Score = 33.1 bits (74), Expect = 0.34
Identities = 44/201 (21%), Positives = 85/201 (42%), Gaps = 13/201 (6%)
Query: 52 QRCLEENQELRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGLEK 111
Q+ E+ +++ A+R++ +IL EL+ +AS + Q+ K + ++ +E+
Sbjct: 296 QKQNEDYEKMIKALRETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEE 355
Query: 112 LDLKRQKEQALREVEHLKRCQQQM-AEDKASVKAQVTSLLGELQESQSRLEAATKECQAL 170
D Q +E Q +D V S+L +++ L Q L
Sbjct: 356 GDNIAQGSGHENSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLR------QQL 409
Query: 171 EGRRKLAQLQVAYHQLFQEYDNHIKSSV--VGSERKRADIYKADFQAE----RQAREKLA 224
G ++ L H ++E ++ + + ER D Q E + RE L
Sbjct: 410 AGCQEAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQ 469
Query: 225 EKKELLQEQLEQLQREYSKLK 245
+ +E L++QLE L++E +L+
Sbjct: 470 KAREELRQQLEVLEQEAWRLR 490
>gi|169218106 PREDICTED: hypothetical protein, partial [Homo
sapiens]
Length = 436
Score = 56.6 bits (135), Expect = 3e-08
Identities = 38/196 (19%), Positives = 104/196 (53%), Gaps = 8/196 (4%)
Query: 77 EELLHFQASQREEKEFLMCKFQEA-RKLVERLGLEKLDLKRQKEQALREVEHLKRCQQQM 135
EE + Q Q +++E M + +E RK E++G ++ +++Q+EQ ++ E +++ ++QM
Sbjct: 205 EEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQM 264
Query: 136 AEDKASVKAQVTSLLGELQESQSRLEAATKECQALEGRRKLAQLQVAYHQLFQEYDNHIK 195
E + ++ Q +L + ++++ + +E Q E ++ + + + QE +
Sbjct: 265 REQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMRE--QEEQMREQ 322
Query: 196 SSVVGSERKRADIYKADFQAERQ----AREKLAEKKELLQEQLEQLQREYSKLKASCQES 251
+G + ++ K +++ E++ E++E +Q+Q EQ++++ +++ ++
Sbjct: 323 EEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQKQEEQVRKQEEQMRKQEEQM 382
Query: 252 ARIED-MRKRHVEVSQ 266
+ E+ MRK+ ++ +
Sbjct: 383 RKQEEQMRKQEEQMGE 398
Score = 54.3 bits (129), Expect = 1e-07
Identities = 47/247 (19%), Positives = 113/247 (45%), Gaps = 17/247 (6%)
Query: 7 KSQLCEMVQPSGGPAADQDVLGEESPLGKPAMLHLPSEQGAPETLQRCLEEN-------- 58
+ Q +M + G ++ +GE+ + M + G E R EE
Sbjct: 188 REQEGQMGEQEGQMGEQEEQMGEQ----EEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQV 243
Query: 59 QELRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGLEKLDLKRQK 118
Q+ + +++ + +R++ EE + Q Q E+E M K +E + E+ G ++ ++ Q+
Sbjct: 244 QKQEEQVQKQEEQMRKQ-EEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQE 302
Query: 119 EQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQALEGRRKLAQ 178
EQ + E ++ ++QM E + + Q + + ++ + E K+ + + + + Q
Sbjct: 303 EQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQ 362
Query: 179 LQVAYHQLFQEYDNHIKSSVVGSERKRADIYKADFQAERQAREKLAEKKELLQEQLEQLQ 238
Q + ++ + ++ ++ + K + Q Q +E++ E+KE ++EQ EQ+
Sbjct: 363 KQ---EEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQ-KEQMGEQKEQMREQEEQMG 418
Query: 239 REYSKLK 245
+ +++
Sbjct: 419 EQKEQMR 425
Score = 44.7 bits (104), Expect = 1e-04
Identities = 34/186 (18%), Positives = 94/186 (50%), Gaps = 5/186 (2%)
Query: 59 QELRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGLEKLDLKRQK 118
+E +R+ +RE+ ++ + RE++ + + + R+ ++G ++ + Q+
Sbjct: 146 REQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQMGEQEGQMGEQE 205
Query: 119 EQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQALEGRRKLAQ 178
EQ + E +++ ++QM E + ++ Q +GE QE Q + + + Q + R++ Q
Sbjct: 206 EQMGEQEEQMQKQEEQMGEQEEQMRKQ-EEQMGE-QEEQVQKQEEQVQKQEEQMRKQEEQ 263
Query: 179 LQVAYHQLFQEYDNHIKSSVVGSERKRADIYKADFQAERQAREKLAEKKELLQEQLEQLQ 238
++ Q+ ++ + +K + ++ + + R+ E++ E++E ++EQ EQ++
Sbjct: 264 MREQEEQMREQEEQMLKQKEQTEQEEQTGEQE---EQMREQEEQMREQEEQMREQEEQMR 320
Query: 239 REYSKL 244
+ ++
Sbjct: 321 EQEEQM 326
Score = 36.6 bits (83), Expect = 0.031
Identities = 22/100 (22%), Positives = 54/100 (54%), Gaps = 1/100 (1%)
Query: 56 EENQELRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGLEKLDLK 115
E+ E ++ + + + + E+ E++ + R+++E + + ++ RK E++ ++ +
Sbjct: 338 EQMWEQKEQMWKQEEQMGEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMG 397
Query: 116 RQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQE 155
QKEQ + E ++ ++QM E K ++ Q +GE +E
Sbjct: 398 EQKEQMGEQKEQMREQEEQMGEQKEQMRKQ-EEHMGEQKE 436
Score = 34.7 bits (78), Expect = 0.12
Identities = 37/231 (16%), Positives = 106/231 (45%), Gaps = 14/231 (6%)
Query: 39 LHLPSEQGAPETLQRCLEENQELRDA---IRQSNQILRERCEELLHFQASQREEKEFLMC 95
LH+ + ET + L + ++R+ +R+ +RE+ ++ + RE++ +
Sbjct: 32 LHIKELKRKLETDKIPLPQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVRE 91
Query: 96 KFQEARKLVERLGLEKLDLKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQE 155
+ + R+ ++ ++ ++ Q+ Q + ++ + Q+ E + V+ Q G+++E
Sbjct: 92 QEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQE----GQVRE 147
Query: 156 SQSRLEAATKECQALEGRRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRADIYKADFQA 215
+ ++ + + EG+ + + QV +E + ++ + + + + Q
Sbjct: 148 QEGQVREQEGQVREQEGQVREQEGQV------REQEGQVREQEGQVREQEGQMGEQEGQM 201
Query: 216 ERQAREKLAEKKELLQEQLEQLQREYSKLKASCQESARIEDMRKRHVEVSQ 266
Q E++ E++E +Q+Q EQ+ + +++ ++ E+ ++ E Q
Sbjct: 202 GEQ-EEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQ 251
Score = 31.2 bits (69), Expect = 1.3
Identities = 15/71 (21%), Positives = 43/71 (60%)
Query: 49 ETLQRCLEENQELRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLG 108
E +Q+ E+ ++ + +R+ + +R++ E++ + E+KE + + ++ R+ E++G
Sbjct: 359 EQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQKEQMREQEEQMG 418
Query: 109 LEKLDLKRQKE 119
+K +++Q+E
Sbjct: 419 EQKEQMRKQEE 429
>gi|145312241 differentially expressed in FDCP 6 homolog [Homo
sapiens]
Length = 631
Score = 56.6 bits (135), Expect = 3e-08
Identities = 50/190 (26%), Positives = 92/190 (48%), Gaps = 13/190 (6%)
Query: 59 QELRDAIRQSNQILRERCEELLHFQASQREEKEFL--MCKFQEARKLVERLGLEKLDLKR 116
Q+ R+ Q + + EELL Q Q E++ L + QEA++ ERL E+ + +R
Sbjct: 327 QKRREQREQRERRRAAKEEELLRLQQLQEEKERKLQELELLQEAQRQAERLLQEEEERRR 386
Query: 117 QK--------EQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQ 168
+ E LRE E + Q E K A+ + EL+E Q RL+ A +
Sbjct: 387 SQHRELQQALEGQLREAEQARASMQAEMELKEEEAARQRQRIKELEEMQQRLQEALQ--L 444
Query: 169 ALEGRRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRADIYKADFQAERQAREKLAEKKE 228
++ RR +++A +L +E + +K + E + I +A Q + + ++++A++
Sbjct: 445 EVKARRDEESVRIAQTRLLEEEEEKLKQLMQLKEEQERYIERAQ-QEKEELQQEMAQQSR 503
Query: 229 LLQEQLEQLQ 238
LQ+ +QL+
Sbjct: 504 SLQQAQQQLE 513
Score = 33.9 bits (76), Expect = 0.20
Identities = 30/143 (20%), Positives = 69/143 (48%), Gaps = 12/143 (8%)
Query: 49 ETLQRCLEENQELRD--AIRQSNQI-----LRERCEELLHFQASQREEKEFLMCKFQEAR 101
E + ++ EL++ A RQ +I +++R +E L + R ++E + + + R
Sbjct: 404 EQARASMQAEMELKEEEAARQRQRIKELEEMQQRLQEALQLEVKARRDEESV--RIAQTR 461
Query: 102 KLVERLGLEKL-DLKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRL 160
L E EKL L + KE+ R +E ++ ++++ ++ A + +L+E +
Sbjct: 462 LLEEEE--EKLKQLMQLKEEQERYIERAQQEKEELQQEMAQQSRSLQQAQQQLEEVRQNR 519
Query: 161 EAATKECQALEGRRKLAQLQVAY 183
+ A ++ +A + + + A V +
Sbjct: 520 QRADEDVEAAQRKLRQASTNVKH 542
>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
Length = 2017
Score = 56.2 bits (134), Expect = 4e-08
Identities = 73/287 (25%), Positives = 133/287 (46%), Gaps = 46/287 (16%)
Query: 41 LPSEQGAPETLQRCLEENQELRDAIRQSNQILRERCEELLHF--QASQREEKEFLMCKFQ 98
L Q E E QE + +R ++ R+ E L QA + E++ + +
Sbjct: 769 LQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHE 828
Query: 99 EAR------KLVERLGLEKLDLKRQKEQALREVEHLKRCQQQ---MAEDKASVKAQVTSL 149
++ +L +L + +L++ + +A R+VE L+R ++ +A++ A + Q L
Sbjct: 829 RSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQ---L 885
Query: 150 LGELQESQSRLEAATK---ECQALEG-----RRKLAQLQVAYHQLFQEYDNHI--KSSVV 199
+ +E ++ E AT+ E +ALEG +R+LAQL+ QL E + K ++
Sbjct: 886 VAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLT 945
Query: 200 G----------SERKRADIYKADF-----QAERQAREKLAEKKELLQEQLEQLQRE---- 240
G + +++A + K QAER+A+ L E++ +E L++LQRE
Sbjct: 946 GELAGLRQQIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAA 1005
Query: 241 YSKLKASCQESARIEDMRKRHVEVSQAPLPPAPAYLSSPLALPSQRR 287
+ +L+A E A+++ +R E A L LS +A Q R
Sbjct: 1006 WRELEA---ERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQER 1049
Score = 54.7 bits (130), Expect = 1e-07
Identities = 70/306 (22%), Positives = 131/306 (42%), Gaps = 50/306 (16%)
Query: 51 LQRCLEENQELRDAIRQSNQILRERCEELLHFQASQR---EEKEFLMCKFQEARKLVE-- 105
L+R L E + R+A+R+SN+ LR ++ + S + E+KE + +EAR V
Sbjct: 1201 LRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKE 1260
Query: 106 ----RLGLEKLDLKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSL-----LGELQES 156
R GL++++ R + +A RE++ L+R + + + + ++ L LGE E
Sbjct: 1261 AGELRTGLQEVE--RSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEK 1318
Query: 157 QSRLEAATKECQALEGRRKL----AQLQVAYHQLFQEYDNHIKS----------SVVGSE 202
+SR E + L+G L +LQVA +L QE + ++ G+E
Sbjct: 1319 ESRRETLGLRQRLLKGEASLEVMRQELQVAQRKL-QEQEGEFRTRERRLLGSLEEARGTE 1377
Query: 203 RKRADIYKA---DFQAERQAREKLAEKKELLQEQLEQLQREYSKL----KASCQESARIE 255
+++ D + +A R +L + + + + L+ E +++ +A+ + +
Sbjct: 1378 KQQLDHARGLELKLEAARAEAAELGLRLSAAEGRAQGLEAELARVEVQRRAAEAQLGGLR 1437
Query: 256 DMRKRHVEVSQAPLPPAPAYLSSP------------LALPSQRRSPPEEPPDFCCPKCQY 303
+R + + +AP P SP L PS P P P
Sbjct: 1438 SALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPATSP 1497
Query: 304 QAPDMD 309
+PD+D
Sbjct: 1498 ASPDLD 1503
Score = 48.1 bits (113), Expect = 1e-05
Identities = 62/281 (22%), Positives = 122/281 (43%), Gaps = 42/281 (14%)
Query: 41 LPSEQGAPETLQRCLEENQEL---RDAIRQSNQILRERCEELLHFQASQREEKEFLMCKF 97
+ + + A +QR N+ L + + S Q+ +++ EEL R+E+E L
Sbjct: 581 MQAHEDAQREVQRLRSANELLSREKSNLAHSLQVAQQQAEEL-------RQEREKLQAAQ 633
Query: 98 QEARKLVERLGLEKLD-------LKRQKEQALREVEHLKRCQQQMAEDKASV-------- 142
+E R+ +RL E+ D ++R+ E++ R++E L+ + +A++ V
Sbjct: 634 EELRRQRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRAT 693
Query: 143 ---------KAQVTSLLGELQESQSRLEAATKECQALEG--RRKLAQLQVAYHQLFQEYD 191
KA+V L + + + LE + + +A E + L++L L Q+
Sbjct: 694 LQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQD-K 752
Query: 192 NHIKSSVVGSERKRADIYKADFQAERQAREKLAEKKELLQEQLEQLQREYSKLKASCQES 251
+ V E +++ + QAE++A E QE+LE+L+ E + + S
Sbjct: 753 LDLNRLVAQLEEEKSALQGRQRQAEQEATVAREE-----QERLEELRLEQEVARQGLEGS 807
Query: 252 ARIEDMRKRHVEVSQAPLPPAPAYLSSPLALPSQRRSPPEE 292
R+ + + +E L + L LA S++ S E+
Sbjct: 808 LRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQ 848
Score = 46.6 bits (109), Expect = 3e-05
Identities = 53/212 (25%), Positives = 95/212 (44%), Gaps = 21/212 (9%)
Query: 55 LEENQELRDAIRQSNQ---ILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGLEK 111
LE ++ RDA + Q + EL +A QREE QE R+L E +
Sbjct: 1090 LEMERQKRDAQSRQEQDRSTVNALTSELRDLRA-QREEAA--AAHAQEVRRLQE----QA 1142
Query: 112 LDLKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQALE 171
DL +Q++ LRE E L+ + + + + ++ ++ +L+ESQ E +E A E
Sbjct: 1143 RDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQE--AGE 1200
Query: 172 GRRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRADIYKADFQAERQAREKLAEKKELLQ 231
RR L + + + + ++S+V +E +R + + A E +K LL+
Sbjct: 1201 LRRSLGE-GAKEREALRRSNEELRSAVKKAESERISL--------KLANEDKEQKLALLE 1251
Query: 232 EQLEQLQREYSKLKASCQESARIEDMRKRHVE 263
E + +E +L+ QE R +R ++
Sbjct: 1252 EARTAVGKEAGELRTGLQEVERSRLEARRELQ 1283
Score = 45.1 bits (105), Expect = 9e-05
Identities = 53/238 (22%), Positives = 98/238 (41%), Gaps = 16/238 (6%)
Query: 8 SQLCEMVQPSGGPAADQDVLGEESPLGKPAMLHLPSEQGAPETLQRCLEENQELRDAIRQ 67
S L E VQ G AD ++ E+ +G + L+ L + QE A
Sbjct: 1785 SSLGEQVQTLRGEVADLELQRVEA-------------EGQLQQLREVLRQRQEGEAAALN 1831
Query: 68 SNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGLEKLDLKRQKEQALREVEH 127
+ Q L++ L S + L + +E + RL +++ L+R ++ RE
Sbjct: 1832 TVQKLQDERRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVALRRTLDKVEREKLR 1891
Query: 128 LKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQALEGRRKLAQLQVAYHQL- 186
+++ +K + +T EL E+Q +++ + LE AQL+V Q
Sbjct: 1892 SHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQQQQ 1951
Query: 187 --FQEYDNHIKSSVVGSERKRADIYKADFQAERQAREKLAEKKELLQEQLEQLQREYS 242
Q+ ++S+ +ER +A Q R E+++ K LQ++L + +S
Sbjct: 1952 LELQQEVERLRSAQAQTERTLEARERAHRQRVRGLEEQVSTLKGQLQQELRRSSAPFS 2009
Score = 42.7 bits (99), Expect = 4e-04
Identities = 60/273 (21%), Positives = 116/273 (42%), Gaps = 45/273 (16%)
Query: 59 QELRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGLEKLDLKRQK 118
Q+ A Q+L+ER + + R++ L + V+ L E DL+ Q+
Sbjct: 1753 QKALTACEHDRQVLQERLDAARQALSEARKQSSSL-------GEQVQTLRGEVADLELQR 1805
Query: 119 EQALREVEHLKRCQQQMAEDKASVKAQVTSL----------LGELQESQSRLEAATKECQ 168
+A +++ L+ +Q E +A+ V L LG LQ + ++LEA +E +
Sbjct: 1806 VEAEGQLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQRALAQLEAEKREVE 1865
Query: 169 ALEGRRKLAQLQVAYHQLFQEYD-----NHIKSSVVGSERKRAD--IYKADFQ---AERQ 218
+L + +VA + + + +H + + +E+ R D + A+ + A+RQ
Sbjct: 1866 --RSALRLEKDRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQ 1923
Query: 219 AREKLAEKKEL------------LQEQLEQLQREYSKLKASCQESARIEDMRKR----HV 262
++ A+ L Q+Q +LQ+E +L+++ ++ R + R+R V
Sbjct: 1924 IQQLEAQVVVLEQSHSPAQLEVDAQQQQLELQQEVERLRSAQAQTERTLEARERAHRQRV 1983
Query: 263 EVSQAPLPPAPAYLSSPLALPSQRRSPPEEPPD 295
+ + L L S SPP PP+
Sbjct: 1984 RGLEEQVSTLKGQLQQELRRSSAPFSPPSGPPE 2016
Score = 42.4 bits (98), Expect = 6e-04
Identities = 47/212 (22%), Positives = 94/212 (44%), Gaps = 24/212 (11%)
Query: 50 TLQRCLEENQELRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGL 109
TL++ L +++ R A+ + Q LR++ + + ++A++ V+RL
Sbjct: 551 TLRKQLSDSESERRALEEQLQRLRDKTDGAMQAH--------------EDAQREVQRLRS 596
Query: 110 EKLDLKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQA 169
L R+K + H + QQ AE+ + ++ + EL+ + RLE +E
Sbjct: 597 ANELLSREKS----NLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLE-EEQEDAV 651
Query: 170 LEGRRKLAQLQVAYHQLFQEYDNHIKSSVVGSE--RKRADIYKADFQAERQAREKLAEKK 227
+G R +L+ ++ QL Q K SV+ E R + +A Q + EK +
Sbjct: 652 QDGARVRRELERSHRQLEQLEG---KRSVLAKELVEVREALSRATLQRDMLQAEKAEVAE 708
Query: 228 ELLQEQLEQLQREYSKLKASCQESARIEDMRK 259
L + + +++ E S K +E++ + + K
Sbjct: 709 ALTKAEAGRVELELSMTKLRAEEASLQDSLSK 740
Score = 38.1 bits (87), Expect = 0.010
Identities = 48/250 (19%), Positives = 100/250 (40%), Gaps = 34/250 (13%)
Query: 54 CLEENQELR----------DAIR--------------QSNQILRERCEELLHFQASQREE 89
CL E +ELR D +R + ++ R+ EL +E
Sbjct: 1152 CLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAGELRRSLGEGAKE 1211
Query: 90 KEFLMCKFQEARKLVERLGLEKLDLKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSL 149
+E L +E R V++ E++ LK E +++ L+ + + ++ ++ + +
Sbjct: 1212 REALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEV 1271
Query: 150 LGELQESQSRLEAATKECQALEGR-----RKLAQLQVAYHQLFQEYDNHIKSSVVGSERK 204
E++ L+ ++ + L+ R+LA+LQ L + + + +G ++
Sbjct: 1272 ERSRLEARRELQELRRQMKMLDSENTRLGRELAELQ-GRLALGERAEKESRRETLGLRQR 1330
Query: 205 RADIYKADFQAERQAREKLAEKKELLQEQLEQLQREYSKLKASCQESARIEDMRKRHVEV 264
+ K + E R++L + LQEQ + + +L S +E+ E + H
Sbjct: 1331 ---LLKGEASLE-VMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHARG 1386
Query: 265 SQAPLPPAPA 274
+ L A A
Sbjct: 1387 LELKLEAARA 1396
Score = 37.4 bits (85), Expect = 0.018
Identities = 77/333 (23%), Positives = 123/333 (36%), Gaps = 78/333 (23%)
Query: 23 DQDVLGEESPLGKPAMLHLPSEQGAPETLQRCLEENQELRDAIRQSNQILRE-------- 74
+Q +L L + + Q L R LEE Q+ ++ Q N +LRE
Sbjct: 191 EQQLLERSGELEQQRLRDTEHSQDLESALIR-LEEEQQRSASLAQVNAMLREQLDQAGSA 249
Query: 75 ----------------RC-EELLHFQASQREEKEFLMCKFQEARKLVERLGLEKLDLKRQ 117
RC +EL H +A+ R E+E F + L + + +R
Sbjct: 250 NQALSEDIRKVTNDWTRCRKELEHREAAWRREEESFNAYFSNEHSRLLLLWRQVVGFRRL 309
Query: 118 KEQALREVEH-LKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQALEGRRKL 176
+ E L + ++A +V+ L L+ ++SR EAA ++ L+
Sbjct: 310 VSEVKMFTERDLLQLGGELARTSRAVQEAGLGLSTGLRLAESRAEAALEKQALLQ----- 364
Query: 177 AQLQVAYHQLFQEYDNHIKSSVVGSERKRADIYKADFQA------------ERQAREK-- 222
AQL+ Q D ++ + ++ ++D+ KAD A E+Q EK
Sbjct: 365 AQLEE------QLRDKVLREKDLAQQQMQSDLDKADLSARVTELGLAVKRLEKQNLEKDQ 418
Query: 223 ----LAEKKELLQ---------------EQLEQLQREYSKLKASCQESARIEDMRKRHVE 263
L EK E L+ E L+Q R+ ++ S ES +R +
Sbjct: 419 VNKDLTEKLEALESLRLQEQAALETEDGEGLQQTLRDLAQAVLSDSESGVQLSGSERTAD 478
Query: 264 VSQAPL-------PPAPAYLSSPLALPSQRRSP 289
S L P+P SSP S RR P
Sbjct: 479 ASNGSLRGLSGQRTPSPPRRSSPGRGRSPRRGP 511
Score = 37.0 bits (84), Expect = 0.023
Identities = 30/121 (24%), Positives = 54/121 (44%), Gaps = 8/121 (6%)
Query: 145 QVTSLLGELQESQSRLEAATKECQALEGRRKLAQLQVAYHQLFQEYDNHIKSSVVGSERK 204
QV + G + SQ L K+ E R+ + Q+ Q + ++ E
Sbjct: 534 QVQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQL------QRLRDKTDGAMQAHEDA 587
Query: 205 RADIYKADFQAERQAREK--LAEKKELLQEQLEQLQREYSKLKASCQESARIEDMRKRHV 262
+ ++ + E +REK LA ++ Q+Q E+L++E KL+A+ +E R D +
Sbjct: 588 QREVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQ 647
Query: 263 E 263
E
Sbjct: 648 E 648
Score = 34.7 bits (78), Expect = 0.12
Identities = 48/202 (23%), Positives = 87/202 (43%), Gaps = 14/202 (6%)
Query: 59 QELRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGLEKLDLKRQK 118
Q+L A R++ LRE + H + QR ++E K R+L + L+R++
Sbjct: 971 QKLVQAEREAQASLRE--QRAAHEEDLQRLQRE----KEAAWRELEAERAQLQSQLQREQ 1024
Query: 119 EQALREVEHLKRCQQQMAEDKASVKAQVTS--LLGELQESQSRLEAATKECQALEGRRKL 176
E+ L +E K ++++E+ A+++ + LL E E Q L E AL +
Sbjct: 1025 EELLARLEAEK---EELSEEIAALQQERDEGLLLAE-SEKQQALSLKESEKTALSEKLMG 1080
Query: 177 AQLQVAYHQLFQEYDNHIKSSVVGSERKRADIYKADFQAERQAREKLAEKKELLQEQLEQ 236
+ +A L E S +R + ++ + R RE+ A +L++
Sbjct: 1081 TRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQE 1140
Query: 237 LQREYSKLKASCQESARIEDMR 258
R+ K + SC A E++R
Sbjct: 1141 QARDLGKQRDSCLREA--EELR 1160
Score = 34.7 bits (78), Expect = 0.12
Identities = 50/226 (22%), Positives = 92/226 (40%), Gaps = 35/226 (15%)
Query: 51 LQRCLEENQELRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQ--------EARK 102
LQ+ + E++E R ++ ++ + E L ++ +R E+E Q +A +
Sbjct: 1556 LQKAVAESEEARRSV--DGRLSGVQAELALQEESVRRSERERRATLDQVATLERSLQATE 1613
Query: 103 LVERLGLEKLDLKRQKEQALR-EVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLE 161
R EK+ + E L + LK ++ Q SL GELQ S+ L
Sbjct: 1614 SELRASQEKISKMKANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLS 1673
Query: 162 AATKECQALEGRRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRADIYKADFQAERQARE 221
+ QAL+ R Q QVA D+ +K+ + +R + A
Sbjct: 1674 DREAQAQALQDRVDSLQRQVA--------DSEVKAGTLQLTVERLN----------GALA 1715
Query: 222 KLAEKKELLQEQLEQLQREYSKLKASCQESARIEDMRKRHVEVSQA 267
K+ E + L++++ L +A Q SA + R +++ + +A
Sbjct: 1716 KVEESEGALRDKVRGL------TEALAQSSASLNSTRDKNLHLQKA 1755
Score = 34.7 bits (78), Expect = 0.12
Identities = 42/164 (25%), Positives = 69/164 (42%), Gaps = 33/164 (20%)
Query: 99 EARKLVERLGLEKLDLKRQKEQALREVEHLKRCQ--QQMAEDKASVKAQV-------TSL 149
+ R L E L L +++ L + L C+ +Q+ +++ Q +S
Sbjct: 1727 KVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQSSS 1786
Query: 150 LGELQESQSRLEAATKECQALEGRRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRADIY 209
LGE Q R E A E Q +E +L QL+ Q QE + ++V
Sbjct: 1787 LGE-QVQTLRGEVADLELQRVEAEGQLQQLREVLRQR-QEGEAAALNTV----------- 1833
Query: 210 KADFQAERQAREKLAEKKELLQEQLEQLQREYSKLKASCQESAR 253
+KL +++ LLQE+L LQR ++L+A +E R
Sbjct: 1834 -----------QKLQDERRLLQERLGSLQRALAQLEAEKREVER 1866
Score = 32.3 bits (72), Expect = 0.58
Identities = 53/223 (23%), Positives = 89/223 (39%), Gaps = 26/223 (11%)
Query: 54 CLEENQELRDAIRQSNQI--LRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGLEK 111
C E+ RD + Q QI L E++ SQ E L A ++ L L++
Sbjct: 28 CQEKGLGARD-LAQDAQITSLPALIREIVTRNLSQPESPVLL-----PATEMASLLSLQE 81
Query: 112 LDLKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQ--- 168
+ Q+E L VE L Q + D+ ++K S E E RLE E Q
Sbjct: 82 ENQLLQQE--LSRVEDLL-AQSRAERDELAIKYNAVS---ERLEQALRLEPGELETQEPR 135
Query: 169 -----ALEGRRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRADIYKADFQAERQAREKL 223
++E RR+L + Q +Y + Q Y + +R + I + + ++ L
Sbjct: 136 GLVRQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQGKILQYKKRCSELEQQLL 195
Query: 224 AEKKELLQEQLEQLQREYSKLKASCQESARIEDMRKRHVEVSQ 266
EL Q++L + A R+E+ ++R ++Q
Sbjct: 196 ERSGELEQQRLRDTEHSQDLESA----LIRLEEEQQRSASLAQ 234
>gi|122937382 Fas (TNFRSF6) binding factor 1 [Homo sapiens]
Length = 1133
Score = 55.5 bits (132), Expect = 6e-08
Identities = 59/230 (25%), Positives = 105/230 (45%), Gaps = 19/230 (8%)
Query: 27 LGEESPLGKPAMLHLPSEQGAPETLQRCLEENQELRDAIRQSNQILRERCEELLHFQASQ 86
L E+S L + + +EQ E++QR LEE +++ + Q+ ER E A
Sbjct: 811 LNEQSRLLEQERWRVTAEQSKAESMQRALEEQRKVT-----AQQMAMERAELERAKSALL 865
Query: 87 REEKEFLMCKFQEARKLVERLGLEKLDLKRQKEQALREVEHLKRCQQQ-------MAEDK 139
E+K ++ +E R+L K KE+A RE E + Q +A+++
Sbjct: 866 EEQKSVMLKCGEERRRLAAEWAEFSAQQKLSKERAEREAERALQVDTQREGTLISLAKEQ 925
Query: 140 ASVKAQVTSLLGELQESQSRLEAATKECQALEGRRKLAQLQVAYHQLFQEYDNHIKSSVV 199
A +K + + L E E Q E A E + E R + ++ ++ + S V
Sbjct: 926 AELKIRASELRAE--EKQLAAERAALEQERQELRLEKERINATALRVKLRAEEVESMSKV 983
Query: 200 GSER----KRADIYKADFQAERQAR-EKLAEKKELLQEQLEQLQREYSKL 244
SE+ +RA QAE+QAR + + +++E L++Q + + +E+ L
Sbjct: 984 ASEKYEEGERALREAQQVQAEQQARLQAVQQQQERLRKQEQHMHQEHLSL 1033
Score = 38.9 bits (89), Expect = 0.006
Identities = 58/224 (25%), Positives = 100/224 (44%), Gaps = 22/224 (9%)
Query: 55 LEENQELRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEA-RKLVERLGLEKLD 113
L +QE IRQ ++ LR E L Q EE+ + QE K+ RL +
Sbjct: 762 LTTSQERELGIRQRDEQLRALQERLGQQQRDMEEERS----RQQEVIGKMEARLNEQSRL 817
Query: 114 LKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRL--EAATKECQALE 171
L++++ + E + Q+ + E + Q+ EL+ ++S L E + + E
Sbjct: 818 LEQERWRVTAEQSKAESMQRALEEQRKVTAQQMAMERAELERAKSALLEEQKSVMLKCGE 877
Query: 172 GRRKL--------AQLQVAYHQLFQEYDNHIKSSVVGSERKRADIYKADFQAERQAR--E 221
RR+L AQ +++ + +E + ++ V ++R+ I A QAE + R E
Sbjct: 878 ERRRLAAEWAEFSAQQKLSKERAEREAERALQ---VDTQREGTLISLAKEQAELKIRASE 934
Query: 222 KLAEKKELLQEQ--LEQLQREYSKLKASCQESARIEDMRKRHVE 263
AE+K+L E+ LEQ ++E K +A +R VE
Sbjct: 935 LRAEEKQLAAERAALEQERQELRLEKERINATALRVKLRAEEVE 978
Score = 33.1 bits (74), Expect = 0.34
Identities = 39/156 (25%), Positives = 65/156 (41%), Gaps = 24/156 (15%)
Query: 132 QQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQALEGRRKLAQLQVAYHQLFQEYD 191
Q+Q+ + ++ L EL SQ+RL + + LE R AQ ++ L Q++
Sbjct: 561 QKQLLAAQVQLQCSPAELQAELLHSQARLAELEAQVRKLELER--AQHELLLGSLQQQHQ 618
Query: 192 NHIKSSVVGSERKRADIYKADFQ--AERQAREK-------LAEKKELLQEQLEQLQREYS 242
++ + + R R + + +Q ER RE L++ +E Q + E +
Sbjct: 619 ADLE-LIESAHRSRIKVLETSYQQREERLRRENEELSARYLSQCQEAEQARAELTAQHQR 677
Query: 243 KLKASCQES------------ARIEDMRKRHVEVSQ 266
+L A QE A I DMR+ H E Q
Sbjct: 678 RLAAIAQEKDQEMERLRELQRASILDMRRDHEEQLQ 713
>gi|58530840 desmoplakin isoform I [Homo sapiens]
Length = 2871
Score = 54.7 bits (130), Expect = 1e-07
Identities = 57/264 (21%), Positives = 116/264 (43%), Gaps = 34/264 (12%)
Query: 40 HLPSEQGAPETLQRCLEENQELRDAIRQSNQILRERCEELLHFQASQREEKEFL---MCK 96
HL +Q E L+R E + LR + Q + +++ HFQ + ++ L +
Sbjct: 1643 HLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNESKIE 1702
Query: 97 FQEARKLVERLGLEKLDLKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTS-------- 148
+ + L E L E L L+ + E + L+R + + DK + ++ S
Sbjct: 1703 IERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSDKNATILELRSQLQISNNR 1762
Query: 149 ------LLGELQESQSRL--EAATKECQALEGRRKLAQLQVAYHQLFQEYDNH-IKSSVV 199
L+ +LQ + L E + QALE ++ + + Q+ QE ++ +K V+
Sbjct: 1763 TLELQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQVVQERESLLVKIKVL 1822
Query: 200 GSERKRADIY-------KADFQAERQAREKLAEKKELLQEQLEQLQREYS-------KLK 245
++ R K+ +AE + +++L +K+ +Q L Q + +YS K++
Sbjct: 1823 EQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIE 1882
Query: 246 ASCQESARIEDMRKRHVEVSQAPL 269
+ ++S R ++ + +E QA +
Sbjct: 1883 SEREKSEREKNSLRSEIERLQAEI 1906
Score = 42.7 bits (99), Expect = 4e-04
Identities = 48/197 (24%), Positives = 86/197 (43%), Gaps = 21/197 (10%)
Query: 65 IRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGLEKLDLKRQKEQALRE 124
+R QI R EL + E+E L + ++ +K + K Q Q ++E
Sbjct: 1752 LRSQLQISNNRTLELQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQVVQE 1811
Query: 125 VEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATK-----ECQALEGRRKLAQL 179
E L + + +DKA ++ L EL ++S LEA T+ EC+ + + L Q
Sbjct: 1812 RESLLVKIKVLEQDKARLQR----LEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQW 1867
Query: 180 QVAYHQLFQEYDNHIKSSVVGSERKR-----------ADIYKADFQAERQAREKLAEKKE 228
+ Y + +E I+S SER++ A+I + + + R+ + E +
Sbjct: 1868 KTQYSRK-EEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLEDSTRETQS 1926
Query: 229 LLQEQLEQLQREYSKLK 245
L+ + + QRE KL+
Sbjct: 1927 QLETERSRYQREIDKLR 1943
Score = 37.0 bits (84), Expect = 0.023
Identities = 47/242 (19%), Positives = 108/242 (44%), Gaps = 25/242 (10%)
Query: 49 ETLQRCLEENQELRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLG 108
+ +Q+ E+N + ++ ++ + ++++ +E+ +A +EE + E K+
Sbjct: 1297 QVMQQRSEDNARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKVRNNYD 1356
Query: 109 LEKLDLKRQKEQALREVE-HLKRCQQQMAEDKASVKAQVTSL-----------------L 150
E + LK Q E + + + + Q ED + +AQ+ +L L
Sbjct: 1357 EEIISLKNQFETEINITKTTIHQLTMQKEEDTSGYRAQIDNLTRENRSLSEEIKRLKNTL 1416
Query: 151 GELQESQSRLEAATKECQAL--EGRRKLAQLQVAYHQLFQ---EYDNHIKSSVVGSERKR 205
+ E+ R+E ++ +A E ++ QL+V Q+ Q E K S+ + +
Sbjct: 1417 TQTTENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQVTQMRTEESVRYKQSLDDAAKTI 1476
Query: 206 ADIYKADFQAERQAREKLAEKKELLQEQLEQLQR-EYSKLKASCQESARIEDMRKRHVEV 264
D K + + +Q +K ++ L+++ +LQR +Y KA+ + I ++ + E+
Sbjct: 1477 QDKNK-EIERLKQLIDKETNDRKCLEDENARLQRVQYDLQKANSSATETINKLKVQEQEL 1535
Query: 265 SQ 266
++
Sbjct: 1536 TR 1537
Score = 35.4 bits (80), Expect = 0.068
Identities = 52/253 (20%), Positives = 111/253 (43%), Gaps = 47/253 (18%)
Query: 51 LQRCLEENQELRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGLE 110
LQR + Q+ + ++ L+ + +EL + + K Q+ + L
Sbjct: 1507 LQRVQYDLQKANSSATETINKLKVQEQELTRLRIDYERVSQERTVKDQDITRFQNSLK-- 1564
Query: 111 KLDLKRQKEQALREVEHLKR------CQQQMAED-----KASVKAQ---VTSLLGELQES 156
+L+ QK++ E+ LKR C+++ E+ + S+K Q +T+L +L+++
Sbjct: 1565 --ELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQA 1622
Query: 157 ------------QSR--LEAATKECQAL--EGRRKLAQLQVAYHQLFQEYDN----HIKS 196
Q R L+ +E Q E RR ++++ QL QE ++ H+++
Sbjct: 1623 SIVKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRN 1682
Query: 197 ----SVVGSERKRADIYKADFQAERQAREKLAEKKELLQEQLEQLQREYSKLK-----AS 247
+ + + + K + + + E L ++ +L+E+L L+ EY L+ A
Sbjct: 1683 EHFQKAIEDKSRSLNESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEAD 1742
Query: 248 CQESARIEDMRKR 260
++A I ++R +
Sbjct: 1743 SDKNATILELRSQ 1755
Score = 34.7 bits (78), Expect = 0.12
Identities = 46/244 (18%), Positives = 105/244 (43%), Gaps = 31/244 (12%)
Query: 45 QGAPETLQRCLEENQELRDAIRQSNQILRE--RCEELLHFQASQREEKEFLMCKFQEARK 102
+ A + L +C + +EL + I + + + R + + + Q++ + K ++ K
Sbjct: 1091 KSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEK 1150
Query: 103 LVERLGLEKLDLKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLE- 161
E LG +KL+ ++ ++ E+E L+ Q+ K + ++ + E S L
Sbjct: 1151 --ENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYNEEMSNLRN 1208
Query: 162 ----------------AATKECQALEGRRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKR 205
+ KE + R +L +L L E S + +E++R
Sbjct: 1209 KYETEINITKTTIKEISMQKEDDSKNLRNQLDRLSRENRDLKDEIVRLNDSILQATEQRR 1268
Query: 206 ADIYKADFQA--ERQAREKLAEKKELLQEQLEQLQREYS----KLKASCQESARIEDMRK 259
+A+ A ++ ++ +KK+ L+ +L+Q+ ++ S + K S +E+A+ +
Sbjct: 1269 ----RAEENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEAAKTIQDKN 1324
Query: 260 RHVE 263
+ +E
Sbjct: 1325 KEIE 1328
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 54.7 bits (130), Expect = 1e-07
Identities = 61/235 (25%), Positives = 109/235 (46%), Gaps = 20/235 (8%)
Query: 45 QGAPETLQRCLEENQELR-DAIRQSNQILR-----ERCEELLHFQASQREEKEFLMCKFQ 98
+G E +R EE +E R A R++ Q R ER ++ QA R + + K +
Sbjct: 2080 RGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLR 2139
Query: 99 -EARKLVERLGLEKLDLKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQ 157
EA + R + RQK+ A E+E K+ +Q KA V+ ++T+L +L+E+
Sbjct: 2140 KEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD 2199
Query: 158 SRLEAATKECQALEGRRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRADIYKADFQAER 217
+ +E Q L+ A+ A Q Q + V E + KA +AE
Sbjct: 2200 HQKNLLDEELQRLK-----AEATEAARQRSQVEEELFSVRVQMEELSK---LKARIEAEN 2251
Query: 218 QA---REKLAEKKELLQ--EQLEQLQREYSKLKASCQESARIEDMRKRHVEVSQA 267
+A R+K ++ L + E+++Q+ E ++L + QE+AR+ + + + +A
Sbjct: 2252 RALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRA 2306
Score = 48.5 bits (114), Expect = 8e-06
Identities = 53/223 (23%), Positives = 90/223 (40%), Gaps = 22/223 (9%)
Query: 68 SNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGLEKLDLKRQKEQALREVEH 127
S +++E + H+ +++ + R++ E L + ++E+ L EVE
Sbjct: 1309 SESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERER-LAEVEA 1367
Query: 128 LKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQALEGRRKLAQLQVAYHQLF 187
Q+Q+AE A KAQ ELQ+ E +E A++ +++ +Q QL
Sbjct: 1368 ALEKQRQLAEAHAQAKAQAEREAKELQQRMQE-EVVRREEAAVDAQQQKRSIQEELQQLR 1426
Query: 188 QEYDNHIKSSVVGSE-------RKRADIYKADFQAERQAREK---------LAEKKELLQ 231
Q + I++ +E R +I Q E R++ L + E +
Sbjct: 1427 QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAE 1486
Query: 232 EQLEQLQREYSKLKASCQESARIEDMRKRHVEVSQAPLPPAPA 274
Q Q Q E +L+ Q+ E RKR EV A A A
Sbjct: 1487 AQKRQAQEEAERLRRQVQD----ESQRKRQAEVELASRVKAEA 1525
Score = 46.6 bits (109), Expect = 3e-05
Identities = 51/214 (23%), Positives = 94/214 (43%), Gaps = 20/214 (9%)
Query: 63 DAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGLEKLDLKRQKEQAL 122
D +R Q E + Q + EE+ + +EA + V++ + + RQ++ AL
Sbjct: 1957 DTLRSKEQAELEAARQR---QLAAEEER-----RRREAEERVQKSLAAEEEAARQRKAAL 2008
Query: 123 REVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQALEGRRKLAQLQVA 182
EVE LK ++ + + + L QE+ + A ++ A ++K +LQ
Sbjct: 2009 EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT 2068
Query: 183 YHQLFQEYDNHIKSSVVGSERKRADIYKADFQAERQAREKLAEKKELLQEQLEQLQREYS 242
Q Q + ++ + R + +A QAER+A + + +E E+L+Q E +
Sbjct: 2069 LQQ-EQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEE--AERLKQSAEEQA 2125
Query: 243 KLKASCQESARIEDMRK-------RHVEVSQAPL 269
+ +A Q +A E +RK R + QA L
Sbjct: 2126 QARAQAQAAA--EKLRKEAEQEAARRAQAEQAAL 2157
Score = 45.1 bits (105), Expect = 9e-05
Identities = 49/202 (24%), Positives = 99/202 (49%), Gaps = 33/202 (16%)
Query: 49 ETLQRCLEENQELRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLG 108
E L+ + E + ++ ++Q ++L+ + EE+ Q Q+E+ QE + L +
Sbjct: 2446 ERLREAIAELEREKEKLQQEAKLLQLKSEEM---QTVQQEQL------LQETQALQQSFL 2496
Query: 109 LEKLDLKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQ 168
EK L +++ R +E K +Q+ +D+ + KAQ +L+E Q R + ++
Sbjct: 2497 SEKDSLLQRE----RFIEQEKAKLEQLFQDEVA-KAQ------QLREEQQRQQQQMEQ-- 2543
Query: 169 ALEGRRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRADIYKADFQAERQAREKLAEKKE 228
E +R +A ++ A + + + G RK+ ++ + + Q RQ E LAE+ +
Sbjct: 2544 --ERQRLVASMEEARRRQHEAEE--------GVRRKQEELQQLE-QQRRQQEELLAEENQ 2592
Query: 229 LLQEQLEQLQREYSKLKASCQE 250
L+EQL+ L+ ++ A +E
Sbjct: 2593 RLREQLQLLEEQHRAALAHSEE 2614
Score = 43.5 bits (101), Expect = 2e-04
Identities = 72/313 (23%), Positives = 136/313 (43%), Gaps = 51/313 (16%)
Query: 12 EMVQPSGGPAADQDVLGEESPLGKPAMLHLP------SEQGAPET--LQRCLEENQELRD 63
+ VQ + A+ ++L ++ L + L ++Q A ET QR LE ++ +
Sbjct: 2317 QAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL 2376
Query: 64 AIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGL---EKLDLKR---- 116
+ + L+ R E+ QA E+ + + +E + + R L EK+ L +
Sbjct: 2377 EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2436
Query: 117 QKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQS-RLEAATKECQALEG--- 172
Q++Q+ + E L+ ++ +K ++ + L + +E Q+ + E +E QAL+
Sbjct: 2437 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2496
Query: 173 ---------RRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRADIYKADFQAERQ----- 218
R + Q + QLFQ D K+ + E++R + + ERQ
Sbjct: 2497 SEKDSLLQRERFIEQEKAKLEQLFQ--DEVAKAQQLREEQQRQ---QQQMEQERQRLVAS 2551
Query: 219 ----------AREKLAEKKELLQEQLEQLQREYSKLKASCQESARIEDMRKRHVEVSQAP 268
A E + K+E LQ QLEQ +R+ +L A +E+ R+ + + E +A
Sbjct: 2552 MEEARRRQHEAEEGVRRKQEELQ-QLEQQRRQQEELLA--EENQRLREQLQLLEEQHRAA 2608
Query: 269 LPPAPAYLSSPLA 281
L + +S +A
Sbjct: 2609 LAHSEEVTASQVA 2621
Score = 41.6 bits (96), Expect = 0.001
Identities = 45/194 (23%), Positives = 89/194 (45%), Gaps = 12/194 (6%)
Query: 56 EENQELRDAIRQSNQILRER--CEELLHFQASQREEKEFLMCKFQEARKLVERLGLEKLD 113
E +EL ++N+ LR R EE+ ++ + E E + +EA + R G +
Sbjct: 1626 EAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK---QKEEAEREARRRGKAEEQ 1682
Query: 114 LKRQKEQALREVEHLKR-----CQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQ 168
RQ+E A +E+E ++ QQ++A ++ ++ + + GE Q E A + +
Sbjct: 1683 AVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQRE 1742
Query: 169 ALEGRRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRADIYKADFQAERQAR--EKLAEK 226
A +K +L+ ++ E + + S E R+ K+ + E +A +LAE+
Sbjct: 1743 AAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE 1802
Query: 227 KELLQEQLEQLQRE 240
L+ E+ +R+
Sbjct: 1803 AARLRALAEEAKRQ 1816
Score = 41.2 bits (95), Expect = 0.001
Identities = 70/254 (27%), Positives = 114/254 (44%), Gaps = 33/254 (12%)
Query: 45 QGAPETLQRCLEENQELRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLV 104
Q E +++ EE L A +++ + LR+ EE L A QR E ++ + +A +
Sbjct: 2267 QEEAEKMKQVAEEAARLSVAAQEAAR-LRQLAEEDL---AQQRALAEKMLKEKMQAVQEA 2322
Query: 105 ERLGLEKLDLKRQKE----QALREVEHLKRCQQQMAED----------------KASVKA 144
RL E L++QKE QA R E ++ QQ+AE+ + S +A
Sbjct: 2323 TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEA 2382
Query: 145 QVTSL-LGELQESQSRLE--AATKECQALEGRRKLAQLQVAYHQ---LFQEYDNHIKSSV 198
+ L + E+ +Q+R E A QA E KL + ++A + L Q + + S
Sbjct: 2383 ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSD 2442
Query: 199 VGSERKRADIYKADFQAER-QAREKLAEKK--ELLQEQLEQLQREYSKLKASCQESARIE 255
+ER R I + + + E+ Q KL + K E+ Q EQL +E L+ S
Sbjct: 2443 HDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL 2502
Query: 256 DMRKRHVEVSQAPL 269
R+R +E +A L
Sbjct: 2503 LQRERFIEQEKAKL 2516
Score = 40.8 bits (94), Expect = 0.002
Identities = 54/252 (21%), Positives = 103/252 (40%), Gaps = 34/252 (13%)
Query: 29 EESPLGKPAMLHLPS----EQGAPETLQRCLEENQELR----DAIRQSNQILRERCEEL- 79
+ES + A + L S E A QR L+ +ELR +A R+ Q ER ++
Sbjct: 1505 DESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQ 1564
Query: 80 LHFQASQREEKEFLMCK---------------------FQEARKLVERLGLEKLDLKRQK 118
+ + +QR + L K + R+ ER ++ + +R +
Sbjct: 1565 VALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAR 1624
Query: 119 EQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQALEGRRKLAQ 178
E+A RE+E Q A + ++ Q + + +Q+ E +E + RR A+
Sbjct: 1625 EEAERELERW----QLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAE 1680
Query: 179 LQVAYHQLFQEYDNHIKSSVVGSERKRADIYKADFQAERQAREKLAEKKELLQEQLEQLQ 238
Q + E + + + ++ + + R E+ ++++LL+E+L +LQ
Sbjct: 1681 EQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQ 1740
Query: 239 REYSKLKASCQE 250
RE + QE
Sbjct: 1741 REAAAATQKRQE 1752
Score = 36.2 bits (82), Expect = 0.040
Identities = 49/216 (22%), Positives = 95/216 (43%), Gaps = 24/216 (11%)
Query: 44 EQGAPETLQRCLEENQELRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKL 103
++ A Q+ E EL + +L + +++ + K+ L + R+L
Sbjct: 1740 QREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL 1799
Query: 104 VE---RLGLEKLDLKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRL 160
E RL + KRQ++ A + +Q AE + V A+ + +GE ++
Sbjct: 1800 AEEAARLRALAEEAKRQRQLAEED------AARQRAEAE-RVLAEKLAAIGEATRLKTEA 1852
Query: 161 EAATKECQALEGR-RKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRADIYKADFQAERQA 219
E A KE +A R R+LA+ + + +E + + +ADI + Q + +
Sbjct: 1853 EIALKEKEAENERLRRLAEDEAFQRRRLEEQ----------AAQHKADIEERLAQLRKAS 1902
Query: 220 REKLAEKKELLQE---QLEQLQREYSKLKASCQESA 252
+L +K L+++ Q Q++ E LKAS +++A
Sbjct: 1903 DSELERQKGLVEDTLRQRRQVEEEILALKASFEKAA 1938
Score = 35.0 bits (79), Expect = 0.089
Identities = 39/204 (19%), Positives = 83/204 (40%), Gaps = 10/204 (4%)
Query: 56 EENQELRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEA---RKLVERLGLEKL 112
E + L + + + R + E + + + E + EA R+L E+ K
Sbjct: 1830 EAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA 1889
Query: 113 DLKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQALEG 172
D++ + Q + + Q+ + ED + QV + L+ S + A E + G
Sbjct: 1890 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 1949
Query: 173 RRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRADIYKADFQAERQAREKLAEKKELLQE 232
R + + E + + + E +R +AE + ++ LA ++E ++
Sbjct: 1950 RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRR------EAEERVQKSLAAEEEAARQ 2003
Query: 233 QLEQLQREYSKLKASCQESARIED 256
+ L+ E +LKA +E+ R+ +
Sbjct: 2004 RKAALE-EVERLKAKVEEARRLRE 2026
Score = 32.0 bits (71), Expect = 0.75
Identities = 43/204 (21%), Positives = 92/204 (45%), Gaps = 16/204 (7%)
Query: 64 AIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERL-GLEKLDLKRQKEQAL 122
A+ + + E+L RE + L Q+AR+ E++ + D + +EQ
Sbjct: 1190 AVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLR 1249
Query: 123 RE---VEHLKRCQQQMAEDKASVKAQVTSLLG---ELQESQSRLE---AATKECQALEGR 173
+E +E ++R +++ E + K + ++ +L +++LE + K+ + G
Sbjct: 1250 QEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGS 1309
Query: 174 RKLAQ----LQVAYHQLFQEYDNHIKSSVVGSERKRADIYKADFQAERQAREKLAEKKEL 229
+ Q L+ Y +L +IK + + R+ + + Q + RE+LAE +
Sbjct: 1310 ESVIQEYVDLRTHYSELTTLTSQYIK-FISETLRRMEEEERLAEQQRAEERERLAEVEAA 1368
Query: 230 LQEQLEQLQREYSKLKASCQESAR 253
L++Q QL +++ KA + A+
Sbjct: 1369 LEKQ-RQLAEAHAQAKAQAEREAK 1391
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 54.7 bits (130), Expect = 1e-07
Identities = 61/235 (25%), Positives = 109/235 (46%), Gaps = 20/235 (8%)
Query: 45 QGAPETLQRCLEENQELR-DAIRQSNQILR-----ERCEELLHFQASQREEKEFLMCKFQ 98
+G E +R EE +E R A R++ Q R ER ++ QA R + + K +
Sbjct: 2084 RGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLR 2143
Query: 99 -EARKLVERLGLEKLDLKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQ 157
EA + R + RQK+ A E+E K+ +Q KA V+ ++T+L +L+E+
Sbjct: 2144 KEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD 2203
Query: 158 SRLEAATKECQALEGRRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRADIYKADFQAER 217
+ +E Q L+ A+ A Q Q + V E + KA +AE
Sbjct: 2204 HQKNLLDEELQRLK-----AEATEAARQRSQVEEELFSVRVQMEELSK---LKARIEAEN 2255
Query: 218 QA---REKLAEKKELLQ--EQLEQLQREYSKLKASCQESARIEDMRKRHVEVSQA 267
+A R+K ++ L + E+++Q+ E ++L + QE+AR+ + + + +A
Sbjct: 2256 RALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRA 2310
Score = 48.5 bits (114), Expect = 8e-06
Identities = 53/223 (23%), Positives = 90/223 (40%), Gaps = 22/223 (9%)
Query: 68 SNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGLEKLDLKRQKEQALREVEH 127
S +++E + H+ +++ + R++ E L + ++E+ L EVE
Sbjct: 1313 SESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERER-LAEVEA 1371
Query: 128 LKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQALEGRRKLAQLQVAYHQLF 187
Q+Q+AE A KAQ ELQ+ E +E A++ +++ +Q QL
Sbjct: 1372 ALEKQRQLAEAHAQAKAQAEREAKELQQRMQE-EVVRREEAAVDAQQQKRSIQEELQQLR 1430
Query: 188 QEYDNHIKSSVVGSE-------RKRADIYKADFQAERQAREK---------LAEKKELLQ 231
Q + I++ +E R +I Q E R++ L + E +
Sbjct: 1431 QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAE 1490
Query: 232 EQLEQLQREYSKLKASCQESARIEDMRKRHVEVSQAPLPPAPA 274
Q Q Q E +L+ Q+ E RKR EV A A A
Sbjct: 1491 AQKRQAQEEAERLRRQVQD----ESQRKRQAEVELASRVKAEA 1529
Score = 46.6 bits (109), Expect = 3e-05
Identities = 51/214 (23%), Positives = 94/214 (43%), Gaps = 20/214 (9%)
Query: 63 DAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGLEKLDLKRQKEQAL 122
D +R Q E + Q + EE+ + +EA + V++ + + RQ++ AL
Sbjct: 1961 DTLRSKEQAELEAARQR---QLAAEEER-----RRREAEERVQKSLAAEEEAARQRKAAL 2012
Query: 123 REVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQALEGRRKLAQLQVA 182
EVE LK ++ + + + L QE+ + A ++ A ++K +LQ
Sbjct: 2013 EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT 2072
Query: 183 YHQLFQEYDNHIKSSVVGSERKRADIYKADFQAERQAREKLAEKKELLQEQLEQLQREYS 242
Q Q + ++ + R + +A QAER+A + + +E E+L+Q E +
Sbjct: 2073 LQQ-EQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEE--AERLKQSAEEQA 2129
Query: 243 KLKASCQESARIEDMRK-------RHVEVSQAPL 269
+ +A Q +A E +RK R + QA L
Sbjct: 2130 QARAQAQAAA--EKLRKEAEQEAARRAQAEQAAL 2161
Score = 45.1 bits (105), Expect = 9e-05
Identities = 49/202 (24%), Positives = 99/202 (49%), Gaps = 33/202 (16%)
Query: 49 ETLQRCLEENQELRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLG 108
E L+ + E + ++ ++Q ++L+ + EE+ Q Q+E+ QE + L +
Sbjct: 2450 ERLREAIAELEREKEKLQQEAKLLQLKSEEM---QTVQQEQL------LQETQALQQSFL 2500
Query: 109 LEKLDLKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQ 168
EK L +++ R +E K +Q+ +D+ + KAQ +L+E Q R + ++
Sbjct: 2501 SEKDSLLQRE----RFIEQEKAKLEQLFQDEVA-KAQ------QLREEQQRQQQQMEQ-- 2547
Query: 169 ALEGRRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRADIYKADFQAERQAREKLAEKKE 228
E +R +A ++ A + + + G RK+ ++ + + Q RQ E LAE+ +
Sbjct: 2548 --ERQRLVASMEEARRRQHEAEE--------GVRRKQEELQQLE-QQRRQQEELLAEENQ 2596
Query: 229 LLQEQLEQLQREYSKLKASCQE 250
L+EQL+ L+ ++ A +E
Sbjct: 2597 RLREQLQLLEEQHRAALAHSEE 2618
Score = 43.5 bits (101), Expect = 2e-04
Identities = 72/313 (23%), Positives = 136/313 (43%), Gaps = 51/313 (16%)
Query: 12 EMVQPSGGPAADQDVLGEESPLGKPAMLHLP------SEQGAPET--LQRCLEENQELRD 63
+ VQ + A+ ++L ++ L + L ++Q A ET QR LE ++ +
Sbjct: 2321 QAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL 2380
Query: 64 AIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGL---EKLDLKR---- 116
+ + L+ R E+ QA E+ + + +E + + R L EK+ L +
Sbjct: 2381 EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2440
Query: 117 QKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQS-RLEAATKECQALEG--- 172
Q++Q+ + E L+ ++ +K ++ + L + +E Q+ + E +E QAL+
Sbjct: 2441 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2500
Query: 173 ---------RRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRADIYKADFQAERQ----- 218
R + Q + QLFQ D K+ + E++R + + ERQ
Sbjct: 2501 SEKDSLLQRERFIEQEKAKLEQLFQ--DEVAKAQQLREEQQRQ---QQQMEQERQRLVAS 2555
Query: 219 ----------AREKLAEKKELLQEQLEQLQREYSKLKASCQESARIEDMRKRHVEVSQAP 268
A E + K+E LQ QLEQ +R+ +L A +E+ R+ + + E +A
Sbjct: 2556 MEEARRRQHEAEEGVRRKQEELQ-QLEQQRRQQEELLA--EENQRLREQLQLLEEQHRAA 2612
Query: 269 LPPAPAYLSSPLA 281
L + +S +A
Sbjct: 2613 LAHSEEVTASQVA 2625
Score = 41.6 bits (96), Expect = 0.001
Identities = 45/194 (23%), Positives = 89/194 (45%), Gaps = 12/194 (6%)
Query: 56 EENQELRDAIRQSNQILRER--CEELLHFQASQREEKEFLMCKFQEARKLVERLGLEKLD 113
E +EL ++N+ LR R EE+ ++ + E E + +EA + R G +
Sbjct: 1630 EAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK---QKEEAEREARRRGKAEEQ 1686
Query: 114 LKRQKEQALREVEHLKR-----CQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQ 168
RQ+E A +E+E ++ QQ++A ++ ++ + + GE Q E A + +
Sbjct: 1687 AVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQRE 1746
Query: 169 ALEGRRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRADIYKADFQAERQAR--EKLAEK 226
A +K +L+ ++ E + + S E R+ K+ + E +A +LAE+
Sbjct: 1747 AAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE 1806
Query: 227 KELLQEQLEQLQRE 240
L+ E+ +R+
Sbjct: 1807 AARLRALAEEAKRQ 1820
Score = 41.2 bits (95), Expect = 0.001
Identities = 70/254 (27%), Positives = 114/254 (44%), Gaps = 33/254 (12%)
Query: 45 QGAPETLQRCLEENQELRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLV 104
Q E +++ EE L A +++ + LR+ EE L A QR E ++ + +A +
Sbjct: 2271 QEEAEKMKQVAEEAARLSVAAQEAAR-LRQLAEEDL---AQQRALAEKMLKEKMQAVQEA 2326
Query: 105 ERLGLEKLDLKRQKE----QALREVEHLKRCQQQMAED----------------KASVKA 144
RL E L++QKE QA R E ++ QQ+AE+ + S +A
Sbjct: 2327 TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEA 2386
Query: 145 QVTSL-LGELQESQSRLE--AATKECQALEGRRKLAQLQVAYHQ---LFQEYDNHIKSSV 198
+ L + E+ +Q+R E A QA E KL + ++A + L Q + + S
Sbjct: 2387 ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSD 2446
Query: 199 VGSERKRADIYKADFQAER-QAREKLAEKK--ELLQEQLEQLQREYSKLKASCQESARIE 255
+ER R I + + + E+ Q KL + K E+ Q EQL +E L+ S
Sbjct: 2447 HDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL 2506
Query: 256 DMRKRHVEVSQAPL 269
R+R +E +A L
Sbjct: 2507 LQRERFIEQEKAKL 2520
Score = 40.8 bits (94), Expect = 0.002
Identities = 54/252 (21%), Positives = 103/252 (40%), Gaps = 34/252 (13%)
Query: 29 EESPLGKPAMLHLPS----EQGAPETLQRCLEENQELR----DAIRQSNQILRERCEEL- 79
+ES + A + L S E A QR L+ +ELR +A R+ Q ER ++
Sbjct: 1509 DESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQ 1568
Query: 80 LHFQASQREEKEFLMCK---------------------FQEARKLVERLGLEKLDLKRQK 118
+ + +QR + L K + R+ ER ++ + +R +
Sbjct: 1569 VALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAR 1628
Query: 119 EQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQALEGRRKLAQ 178
E+A RE+E Q A + ++ Q + + +Q+ E +E + RR A+
Sbjct: 1629 EEAERELERW----QLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAE 1684
Query: 179 LQVAYHQLFQEYDNHIKSSVVGSERKRADIYKADFQAERQAREKLAEKKELLQEQLEQLQ 238
Q + E + + + ++ + + R E+ ++++LL+E+L +LQ
Sbjct: 1685 EQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQ 1744
Query: 239 REYSKLKASCQE 250
RE + QE
Sbjct: 1745 REAAAATQKRQE 1756
Score = 36.2 bits (82), Expect = 0.040
Identities = 49/216 (22%), Positives = 95/216 (43%), Gaps = 24/216 (11%)
Query: 44 EQGAPETLQRCLEENQELRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKL 103
++ A Q+ E EL + +L + +++ + K+ L + R+L
Sbjct: 1744 QREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL 1803
Query: 104 VE---RLGLEKLDLKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRL 160
E RL + KRQ++ A + +Q AE + V A+ + +GE ++
Sbjct: 1804 AEEAARLRALAEEAKRQRQLAEED------AARQRAEAE-RVLAEKLAAIGEATRLKTEA 1856
Query: 161 EAATKECQALEGR-RKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRADIYKADFQAERQA 219
E A KE +A R R+LA+ + + +E + + +ADI + Q + +
Sbjct: 1857 EIALKEKEAENERLRRLAEDEAFQRRRLEEQ----------AAQHKADIEERLAQLRKAS 1906
Query: 220 REKLAEKKELLQE---QLEQLQREYSKLKASCQESA 252
+L +K L+++ Q Q++ E LKAS +++A
Sbjct: 1907 DSELERQKGLVEDTLRQRRQVEEEILALKASFEKAA 1942
Score = 35.0 bits (79), Expect = 0.089
Identities = 39/204 (19%), Positives = 83/204 (40%), Gaps = 10/204 (4%)
Query: 56 EENQELRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEA---RKLVERLGLEKL 112
E + L + + + R + E + + + E + EA R+L E+ K
Sbjct: 1834 EAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA 1893
Query: 113 DLKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQALEG 172
D++ + Q + + Q+ + ED + QV + L+ S + A E + G
Sbjct: 1894 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 1953
Query: 173 RRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRADIYKADFQAERQAREKLAEKKELLQE 232
R + + E + + + E +R +AE + ++ LA ++E ++
Sbjct: 1954 RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRR------EAEERVQKSLAAEEEAARQ 2007
Query: 233 QLEQLQREYSKLKASCQESARIED 256
+ L+ E +LKA +E+ R+ +
Sbjct: 2008 RKAALE-EVERLKAKVEEARRLRE 2030
Score = 32.0 bits (71), Expect = 0.75
Identities = 43/204 (21%), Positives = 92/204 (45%), Gaps = 16/204 (7%)
Query: 64 AIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERL-GLEKLDLKRQKEQAL 122
A+ + + E+L RE + L Q+AR+ E++ + D + +EQ
Sbjct: 1194 AVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLR 1253
Query: 123 RE---VEHLKRCQQQMAEDKASVKAQVTSLLG---ELQESQSRLE---AATKECQALEGR 173
+E +E ++R +++ E + K + ++ +L +++LE + K+ + G
Sbjct: 1254 QEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGS 1313
Query: 174 RKLAQ----LQVAYHQLFQEYDNHIKSSVVGSERKRADIYKADFQAERQAREKLAEKKEL 229
+ Q L+ Y +L +IK + + R+ + + Q + RE+LAE +
Sbjct: 1314 ESVIQEYVDLRTHYSELTTLTSQYIK-FISETLRRMEEEERLAEQQRAEERERLAEVEAA 1372
Query: 230 LQEQLEQLQREYSKLKASCQESAR 253
L++Q QL +++ KA + A+
Sbjct: 1373 LEKQ-RQLAEAHAQAKAQAEREAK 1395
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 54.7 bits (130), Expect = 1e-07
Identities = 61/235 (25%), Positives = 109/235 (46%), Gaps = 20/235 (8%)
Query: 45 QGAPETLQRCLEENQELR-DAIRQSNQILR-----ERCEELLHFQASQREEKEFLMCKFQ 98
+G E +R EE +E R A R++ Q R ER ++ QA R + + K +
Sbjct: 2080 RGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLR 2139
Query: 99 -EARKLVERLGLEKLDLKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQ 157
EA + R + RQK+ A E+E K+ +Q KA V+ ++T+L +L+E+
Sbjct: 2140 KEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD 2199
Query: 158 SRLEAATKECQALEGRRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRADIYKADFQAER 217
+ +E Q L+ A+ A Q Q + V E + KA +AE
Sbjct: 2200 HQKNLLDEELQRLK-----AEATEAARQRSQVEEELFSVRVQMEELSK---LKARIEAEN 2251
Query: 218 QA---REKLAEKKELLQ--EQLEQLQREYSKLKASCQESARIEDMRKRHVEVSQA 267
+A R+K ++ L + E+++Q+ E ++L + QE+AR+ + + + +A
Sbjct: 2252 RALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRA 2306
Score = 48.5 bits (114), Expect = 8e-06
Identities = 53/223 (23%), Positives = 90/223 (40%), Gaps = 22/223 (9%)
Query: 68 SNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGLEKLDLKRQKEQALREVEH 127
S +++E + H+ +++ + R++ E L + ++E+ L EVE
Sbjct: 1309 SESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERER-LAEVEA 1367
Query: 128 LKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQALEGRRKLAQLQVAYHQLF 187
Q+Q+AE A KAQ ELQ+ E +E A++ +++ +Q QL
Sbjct: 1368 ALEKQRQLAEAHAQAKAQAEREAKELQQRMQE-EVVRREEAAVDAQQQKRSIQEELQQLR 1426
Query: 188 QEYDNHIKSSVVGSE-------RKRADIYKADFQAERQAREK---------LAEKKELLQ 231
Q + I++ +E R +I Q E R++ L + E +
Sbjct: 1427 QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAE 1486
Query: 232 EQLEQLQREYSKLKASCQESARIEDMRKRHVEVSQAPLPPAPA 274
Q Q Q E +L+ Q+ E RKR EV A A A
Sbjct: 1487 AQKRQAQEEAERLRRQVQD----ESQRKRQAEVELASRVKAEA 1525
Score = 46.6 bits (109), Expect = 3e-05
Identities = 51/214 (23%), Positives = 94/214 (43%), Gaps = 20/214 (9%)
Query: 63 DAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGLEKLDLKRQKEQAL 122
D +R Q E + Q + EE+ + +EA + V++ + + RQ++ AL
Sbjct: 1957 DTLRSKEQAELEAARQR---QLAAEEER-----RRREAEERVQKSLAAEEEAARQRKAAL 2008
Query: 123 REVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQALEGRRKLAQLQVA 182
EVE LK ++ + + + L QE+ + A ++ A ++K +LQ
Sbjct: 2009 EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT 2068
Query: 183 YHQLFQEYDNHIKSSVVGSERKRADIYKADFQAERQAREKLAEKKELLQEQLEQLQREYS 242
Q Q + ++ + R + +A QAER+A + + +E E+L+Q E +
Sbjct: 2069 LQQ-EQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEE--AERLKQSAEEQA 2125
Query: 243 KLKASCQESARIEDMRK-------RHVEVSQAPL 269
+ +A Q +A E +RK R + QA L
Sbjct: 2126 QARAQAQAAA--EKLRKEAEQEAARRAQAEQAAL 2157
Score = 45.1 bits (105), Expect = 9e-05
Identities = 49/202 (24%), Positives = 99/202 (49%), Gaps = 33/202 (16%)
Query: 49 ETLQRCLEENQELRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLG 108
E L+ + E + ++ ++Q ++L+ + EE+ Q Q+E+ QE + L +
Sbjct: 2446 ERLREAIAELEREKEKLQQEAKLLQLKSEEM---QTVQQEQL------LQETQALQQSFL 2496
Query: 109 LEKLDLKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQ 168
EK L +++ R +E K +Q+ +D+ + KAQ +L+E Q R + ++
Sbjct: 2497 SEKDSLLQRE----RFIEQEKAKLEQLFQDEVA-KAQ------QLREEQQRQQQQMEQ-- 2543
Query: 169 ALEGRRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRADIYKADFQAERQAREKLAEKKE 228
E +R +A ++ A + + + G RK+ ++ + + Q RQ E LAE+ +
Sbjct: 2544 --ERQRLVASMEEARRRQHEAEE--------GVRRKQEELQQLE-QQRRQQEELLAEENQ 2592
Query: 229 LLQEQLEQLQREYSKLKASCQE 250
L+EQL+ L+ ++ A +E
Sbjct: 2593 RLREQLQLLEEQHRAALAHSEE 2614
Score = 43.5 bits (101), Expect = 2e-04
Identities = 72/313 (23%), Positives = 136/313 (43%), Gaps = 51/313 (16%)
Query: 12 EMVQPSGGPAADQDVLGEESPLGKPAMLHLP------SEQGAPET--LQRCLEENQELRD 63
+ VQ + A+ ++L ++ L + L ++Q A ET QR LE ++ +
Sbjct: 2317 QAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL 2376
Query: 64 AIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGL---EKLDLKR---- 116
+ + L+ R E+ QA E+ + + +E + + R L EK+ L +
Sbjct: 2377 EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2436
Query: 117 QKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQS-RLEAATKECQALEG--- 172
Q++Q+ + E L+ ++ +K ++ + L + +E Q+ + E +E QAL+
Sbjct: 2437 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2496
Query: 173 ---------RRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRADIYKADFQAERQ----- 218
R + Q + QLFQ D K+ + E++R + + ERQ
Sbjct: 2497 SEKDSLLQRERFIEQEKAKLEQLFQ--DEVAKAQQLREEQQRQ---QQQMEQERQRLVAS 2551
Query: 219 ----------AREKLAEKKELLQEQLEQLQREYSKLKASCQESARIEDMRKRHVEVSQAP 268
A E + K+E LQ QLEQ +R+ +L A +E+ R+ + + E +A
Sbjct: 2552 MEEARRRQHEAEEGVRRKQEELQ-QLEQQRRQQEELLA--EENQRLREQLQLLEEQHRAA 2608
Query: 269 LPPAPAYLSSPLA 281
L + +S +A
Sbjct: 2609 LAHSEEVTASQVA 2621
Score = 41.6 bits (96), Expect = 0.001
Identities = 45/194 (23%), Positives = 89/194 (45%), Gaps = 12/194 (6%)
Query: 56 EENQELRDAIRQSNQILRER--CEELLHFQASQREEKEFLMCKFQEARKLVERLGLEKLD 113
E +EL ++N+ LR R EE+ ++ + E E + +EA + R G +
Sbjct: 1626 EAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK---QKEEAEREARRRGKAEEQ 1682
Query: 114 LKRQKEQALREVEHLKR-----CQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQ 168
RQ+E A +E+E ++ QQ++A ++ ++ + + GE Q E A + +
Sbjct: 1683 AVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQRE 1742
Query: 169 ALEGRRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRADIYKADFQAERQAR--EKLAEK 226
A +K +L+ ++ E + + S E R+ K+ + E +A +LAE+
Sbjct: 1743 AAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE 1802
Query: 227 KELLQEQLEQLQRE 240
L+ E+ +R+
Sbjct: 1803 AARLRALAEEAKRQ 1816
Score = 41.2 bits (95), Expect = 0.001
Identities = 70/254 (27%), Positives = 114/254 (44%), Gaps = 33/254 (12%)
Query: 45 QGAPETLQRCLEENQELRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLV 104
Q E +++ EE L A +++ + LR+ EE L A QR E ++ + +A +
Sbjct: 2267 QEEAEKMKQVAEEAARLSVAAQEAAR-LRQLAEEDL---AQQRALAEKMLKEKMQAVQEA 2322
Query: 105 ERLGLEKLDLKRQKE----QALREVEHLKRCQQQMAED----------------KASVKA 144
RL E L++QKE QA R E ++ QQ+AE+ + S +A
Sbjct: 2323 TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEA 2382
Query: 145 QVTSL-LGELQESQSRLE--AATKECQALEGRRKLAQLQVAYHQ---LFQEYDNHIKSSV 198
+ L + E+ +Q+R E A QA E KL + ++A + L Q + + S
Sbjct: 2383 ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSD 2442
Query: 199 VGSERKRADIYKADFQAER-QAREKLAEKK--ELLQEQLEQLQREYSKLKASCQESARIE 255
+ER R I + + + E+ Q KL + K E+ Q EQL +E L+ S
Sbjct: 2443 HDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL 2502
Query: 256 DMRKRHVEVSQAPL 269
R+R +E +A L
Sbjct: 2503 LQRERFIEQEKAKL 2516
Score = 40.8 bits (94), Expect = 0.002
Identities = 54/252 (21%), Positives = 103/252 (40%), Gaps = 34/252 (13%)
Query: 29 EESPLGKPAMLHLPS----EQGAPETLQRCLEENQELR----DAIRQSNQILRERCEEL- 79
+ES + A + L S E A QR L+ +ELR +A R+ Q ER ++
Sbjct: 1505 DESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQ 1564
Query: 80 LHFQASQREEKEFLMCK---------------------FQEARKLVERLGLEKLDLKRQK 118
+ + +QR + L K + R+ ER ++ + +R +
Sbjct: 1565 VALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAR 1624
Query: 119 EQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQALEGRRKLAQ 178
E+A RE+E Q A + ++ Q + + +Q+ E +E + RR A+
Sbjct: 1625 EEAERELERW----QLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAE 1680
Query: 179 LQVAYHQLFQEYDNHIKSSVVGSERKRADIYKADFQAERQAREKLAEKKELLQEQLEQLQ 238
Q + E + + + ++ + + R E+ ++++LL+E+L +LQ
Sbjct: 1681 EQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQ 1740
Query: 239 REYSKLKASCQE 250
RE + QE
Sbjct: 1741 REAAAATQKRQE 1752
Score = 36.2 bits (82), Expect = 0.040
Identities = 49/216 (22%), Positives = 95/216 (43%), Gaps = 24/216 (11%)
Query: 44 EQGAPETLQRCLEENQELRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKL 103
++ A Q+ E EL + +L + +++ + K+ L + R+L
Sbjct: 1740 QREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL 1799
Query: 104 VE---RLGLEKLDLKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRL 160
E RL + KRQ++ A + +Q AE + V A+ + +GE ++
Sbjct: 1800 AEEAARLRALAEEAKRQRQLAEED------AARQRAEAE-RVLAEKLAAIGEATRLKTEA 1852
Query: 161 EAATKECQALEGR-RKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRADIYKADFQAERQA 219
E A KE +A R R+LA+ + + +E + + +ADI + Q + +
Sbjct: 1853 EIALKEKEAENERLRRLAEDEAFQRRRLEEQ----------AAQHKADIEERLAQLRKAS 1902
Query: 220 REKLAEKKELLQE---QLEQLQREYSKLKASCQESA 252
+L +K L+++ Q Q++ E LKAS +++A
Sbjct: 1903 DSELERQKGLVEDTLRQRRQVEEEILALKASFEKAA 1938
Score = 35.0 bits (79), Expect = 0.089
Identities = 39/204 (19%), Positives = 83/204 (40%), Gaps = 10/204 (4%)
Query: 56 EENQELRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEA---RKLVERLGLEKL 112
E + L + + + R + E + + + E + EA R+L E+ K
Sbjct: 1830 EAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA 1889
Query: 113 DLKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQALEG 172
D++ + Q + + Q+ + ED + QV + L+ S + A E + G
Sbjct: 1890 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 1949
Query: 173 RRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRADIYKADFQAERQAREKLAEKKELLQE 232
R + + E + + + E +R +AE + ++ LA ++E ++
Sbjct: 1950 RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRR------EAEERVQKSLAAEEEAARQ 2003
Query: 233 QLEQLQREYSKLKASCQESARIED 256
+ L+ E +LKA +E+ R+ +
Sbjct: 2004 RKAALE-EVERLKAKVEEARRLRE 2026
Score = 32.0 bits (71), Expect = 0.75
Identities = 43/204 (21%), Positives = 92/204 (45%), Gaps = 16/204 (7%)
Query: 64 AIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERL-GLEKLDLKRQKEQAL 122
A+ + + E+L RE + L Q+AR+ E++ + D + +EQ
Sbjct: 1190 AVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLR 1249
Query: 123 RE---VEHLKRCQQQMAEDKASVKAQVTSLLG---ELQESQSRLE---AATKECQALEGR 173
+E +E ++R +++ E + K + ++ +L +++LE + K+ + G
Sbjct: 1250 QEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGS 1309
Query: 174 RKLAQ----LQVAYHQLFQEYDNHIKSSVVGSERKRADIYKADFQAERQAREKLAEKKEL 229
+ Q L+ Y +L +IK + + R+ + + Q + RE+LAE +
Sbjct: 1310 ESVIQEYVDLRTHYSELTTLTSQYIK-FISETLRRMEEEERLAEQQRAEERERLAEVEAA 1368
Query: 230 LQEQLEQLQREYSKLKASCQESAR 253
L++Q QL +++ KA + A+
Sbjct: 1369 LEKQ-RQLAEAHAQAKAQAEREAK 1391
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 54.7 bits (130), Expect = 1e-07
Identities = 61/235 (25%), Positives = 109/235 (46%), Gaps = 20/235 (8%)
Query: 45 QGAPETLQRCLEENQELR-DAIRQSNQILR-----ERCEELLHFQASQREEKEFLMCKFQ 98
+G E +R EE +E R A R++ Q R ER ++ QA R + + K +
Sbjct: 2048 RGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLR 2107
Query: 99 -EARKLVERLGLEKLDLKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQ 157
EA + R + RQK+ A E+E K+ +Q KA V+ ++T+L +L+E+
Sbjct: 2108 KEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD 2167
Query: 158 SRLEAATKECQALEGRRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRADIYKADFQAER 217
+ +E Q L+ A+ A Q Q + V E + KA +AE
Sbjct: 2168 HQKNLLDEELQRLK-----AEATEAARQRSQVEEELFSVRVQMEELSK---LKARIEAEN 2219
Query: 218 QA---REKLAEKKELLQ--EQLEQLQREYSKLKASCQESARIEDMRKRHVEVSQA 267
+A R+K ++ L + E+++Q+ E ++L + QE+AR+ + + + +A
Sbjct: 2220 RALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRA 2274
Score = 48.5 bits (114), Expect = 8e-06
Identities = 53/223 (23%), Positives = 90/223 (40%), Gaps = 22/223 (9%)
Query: 68 SNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGLEKLDLKRQKEQALREVEH 127
S +++E + H+ +++ + R++ E L + ++E+ L EVE
Sbjct: 1277 SESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERER-LAEVEA 1335
Query: 128 LKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQALEGRRKLAQLQVAYHQLF 187
Q+Q+AE A KAQ ELQ+ E +E A++ +++ +Q QL
Sbjct: 1336 ALEKQRQLAEAHAQAKAQAEREAKELQQRMQE-EVVRREEAAVDAQQQKRSIQEELQQLR 1394
Query: 188 QEYDNHIKSSVVGSE-------RKRADIYKADFQAERQAREK---------LAEKKELLQ 231
Q + I++ +E R +I Q E R++ L + E +
Sbjct: 1395 QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAE 1454
Query: 232 EQLEQLQREYSKLKASCQESARIEDMRKRHVEVSQAPLPPAPA 274
Q Q Q E +L+ Q+ E RKR EV A A A
Sbjct: 1455 AQKRQAQEEAERLRRQVQD----ESQRKRQAEVELASRVKAEA 1493
Score = 46.6 bits (109), Expect = 3e-05
Identities = 51/214 (23%), Positives = 94/214 (43%), Gaps = 20/214 (9%)
Query: 63 DAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGLEKLDLKRQKEQAL 122
D +R Q E + Q + EE+ + +EA + V++ + + RQ++ AL
Sbjct: 1925 DTLRSKEQAELEAARQR---QLAAEEER-----RRREAEERVQKSLAAEEEAARQRKAAL 1976
Query: 123 REVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQALEGRRKLAQLQVA 182
EVE LK ++ + + + L QE+ + A ++ A ++K +LQ
Sbjct: 1977 EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT 2036
Query: 183 YHQLFQEYDNHIKSSVVGSERKRADIYKADFQAERQAREKLAEKKELLQEQLEQLQREYS 242
Q Q + ++ + R + +A QAER+A + + +E E+L+Q E +
Sbjct: 2037 LQQ-EQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEE--AERLKQSAEEQA 2093
Query: 243 KLKASCQESARIEDMRK-------RHVEVSQAPL 269
+ +A Q +A E +RK R + QA L
Sbjct: 2094 QARAQAQAAA--EKLRKEAEQEAARRAQAEQAAL 2125
Score = 45.1 bits (105), Expect = 9e-05
Identities = 49/202 (24%), Positives = 99/202 (49%), Gaps = 33/202 (16%)
Query: 49 ETLQRCLEENQELRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLG 108
E L+ + E + ++ ++Q ++L+ + EE+ Q Q+E+ QE + L +
Sbjct: 2414 ERLREAIAELEREKEKLQQEAKLLQLKSEEM---QTVQQEQL------LQETQALQQSFL 2464
Query: 109 LEKLDLKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQ 168
EK L +++ R +E K +Q+ +D+ + KAQ +L+E Q R + ++
Sbjct: 2465 SEKDSLLQRE----RFIEQEKAKLEQLFQDEVA-KAQ------QLREEQQRQQQQMEQ-- 2511
Query: 169 ALEGRRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRADIYKADFQAERQAREKLAEKKE 228
E +R +A ++ A + + + G RK+ ++ + + Q RQ E LAE+ +
Sbjct: 2512 --ERQRLVASMEEARRRQHEAEE--------GVRRKQEELQQLE-QQRRQQEELLAEENQ 2560
Query: 229 LLQEQLEQLQREYSKLKASCQE 250
L+EQL+ L+ ++ A +E
Sbjct: 2561 RLREQLQLLEEQHRAALAHSEE 2582
Score = 43.5 bits (101), Expect = 2e-04
Identities = 72/313 (23%), Positives = 136/313 (43%), Gaps = 51/313 (16%)
Query: 12 EMVQPSGGPAADQDVLGEESPLGKPAMLHLP------SEQGAPET--LQRCLEENQELRD 63
+ VQ + A+ ++L ++ L + L ++Q A ET QR LE ++ +
Sbjct: 2285 QAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL 2344
Query: 64 AIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGL---EKLDLKR---- 116
+ + L+ R E+ QA E+ + + +E + + R L EK+ L +
Sbjct: 2345 EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2404
Query: 117 QKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQS-RLEAATKECQALEG--- 172
Q++Q+ + E L+ ++ +K ++ + L + +E Q+ + E +E QAL+
Sbjct: 2405 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2464
Query: 173 ---------RRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRADIYKADFQAERQ----- 218
R + Q + QLFQ D K+ + E++R + + ERQ
Sbjct: 2465 SEKDSLLQRERFIEQEKAKLEQLFQ--DEVAKAQQLREEQQRQ---QQQMEQERQRLVAS 2519
Query: 219 ----------AREKLAEKKELLQEQLEQLQREYSKLKASCQESARIEDMRKRHVEVSQAP 268
A E + K+E LQ QLEQ +R+ +L A +E+ R+ + + E +A
Sbjct: 2520 MEEARRRQHEAEEGVRRKQEELQ-QLEQQRRQQEELLA--EENQRLREQLQLLEEQHRAA 2576
Query: 269 LPPAPAYLSSPLA 281
L + +S +A
Sbjct: 2577 LAHSEEVTASQVA 2589
Score = 41.6 bits (96), Expect = 0.001
Identities = 45/194 (23%), Positives = 89/194 (45%), Gaps = 12/194 (6%)
Query: 56 EENQELRDAIRQSNQILRER--CEELLHFQASQREEKEFLMCKFQEARKLVERLGLEKLD 113
E +EL ++N+ LR R EE+ ++ + E E + +EA + R G +
Sbjct: 1594 EAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK---QKEEAEREARRRGKAEEQ 1650
Query: 114 LKRQKEQALREVEHLKR-----CQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQ 168
RQ+E A +E+E ++ QQ++A ++ ++ + + GE Q E A + +
Sbjct: 1651 AVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQRE 1710
Query: 169 ALEGRRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRADIYKADFQAERQAR--EKLAEK 226
A +K +L+ ++ E + + S E R+ K+ + E +A +LAE+
Sbjct: 1711 AAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE 1770
Query: 227 KELLQEQLEQLQRE 240
L+ E+ +R+
Sbjct: 1771 AARLRALAEEAKRQ 1784
Score = 41.2 bits (95), Expect = 0.001
Identities = 70/254 (27%), Positives = 114/254 (44%), Gaps = 33/254 (12%)
Query: 45 QGAPETLQRCLEENQELRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLV 104
Q E +++ EE L A +++ + LR+ EE L A QR E ++ + +A +
Sbjct: 2235 QEEAEKMKQVAEEAARLSVAAQEAAR-LRQLAEEDL---AQQRALAEKMLKEKMQAVQEA 2290
Query: 105 ERLGLEKLDLKRQKE----QALREVEHLKRCQQQMAED----------------KASVKA 144
RL E L++QKE QA R E ++ QQ+AE+ + S +A
Sbjct: 2291 TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEA 2350
Query: 145 QVTSL-LGELQESQSRLE--AATKECQALEGRRKLAQLQVAYHQ---LFQEYDNHIKSSV 198
+ L + E+ +Q+R E A QA E KL + ++A + L Q + + S
Sbjct: 2351 ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSD 2410
Query: 199 VGSERKRADIYKADFQAER-QAREKLAEKK--ELLQEQLEQLQREYSKLKASCQESARIE 255
+ER R I + + + E+ Q KL + K E+ Q EQL +E L+ S
Sbjct: 2411 HDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL 2470
Query: 256 DMRKRHVEVSQAPL 269
R+R +E +A L
Sbjct: 2471 LQRERFIEQEKAKL 2484
Score = 40.8 bits (94), Expect = 0.002
Identities = 54/252 (21%), Positives = 103/252 (40%), Gaps = 34/252 (13%)
Query: 29 EESPLGKPAMLHLPS----EQGAPETLQRCLEENQELR----DAIRQSNQILRERCEEL- 79
+ES + A + L S E A QR L+ +ELR +A R+ Q ER ++
Sbjct: 1473 DESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQ 1532
Query: 80 LHFQASQREEKEFLMCK---------------------FQEARKLVERLGLEKLDLKRQK 118
+ + +QR + L K + R+ ER ++ + +R +
Sbjct: 1533 VALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAR 1592
Query: 119 EQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQALEGRRKLAQ 178
E+A RE+E Q A + ++ Q + + +Q+ E +E + RR A+
Sbjct: 1593 EEAERELERW----QLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAE 1648
Query: 179 LQVAYHQLFQEYDNHIKSSVVGSERKRADIYKADFQAERQAREKLAEKKELLQEQLEQLQ 238
Q + E + + + ++ + + R E+ ++++LL+E+L +LQ
Sbjct: 1649 EQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQ 1708
Query: 239 REYSKLKASCQE 250
RE + QE
Sbjct: 1709 REAAAATQKRQE 1720
Score = 36.2 bits (82), Expect = 0.040
Identities = 49/216 (22%), Positives = 95/216 (43%), Gaps = 24/216 (11%)
Query: 44 EQGAPETLQRCLEENQELRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKL 103
++ A Q+ E EL + +L + +++ + K+ L + R+L
Sbjct: 1708 QREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL 1767
Query: 104 VE---RLGLEKLDLKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRL 160
E RL + KRQ++ A + +Q AE + V A+ + +GE ++
Sbjct: 1768 AEEAARLRALAEEAKRQRQLAEED------AARQRAEAE-RVLAEKLAAIGEATRLKTEA 1820
Query: 161 EAATKECQALEGR-RKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRADIYKADFQAERQA 219
E A KE +A R R+LA+ + + +E + + +ADI + Q + +
Sbjct: 1821 EIALKEKEAENERLRRLAEDEAFQRRRLEEQ----------AAQHKADIEERLAQLRKAS 1870
Query: 220 REKLAEKKELLQE---QLEQLQREYSKLKASCQESA 252
+L +K L+++ Q Q++ E LKAS +++A
Sbjct: 1871 DSELERQKGLVEDTLRQRRQVEEEILALKASFEKAA 1906
Score = 35.0 bits (79), Expect = 0.089
Identities = 39/204 (19%), Positives = 83/204 (40%), Gaps = 10/204 (4%)
Query: 56 EENQELRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEA---RKLVERLGLEKL 112
E + L + + + R + E + + + E + EA R+L E+ K
Sbjct: 1798 EAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA 1857
Query: 113 DLKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQALEG 172
D++ + Q + + Q+ + ED + QV + L+ S + A E + G
Sbjct: 1858 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 1917
Query: 173 RRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRADIYKADFQAERQAREKLAEKKELLQE 232
R + + E + + + E +R +AE + ++ LA ++E ++
Sbjct: 1918 RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRR------EAEERVQKSLAAEEEAARQ 1971
Query: 233 QLEQLQREYSKLKASCQESARIED 256
+ L+ E +LKA +E+ R+ +
Sbjct: 1972 RKAALE-EVERLKAKVEEARRLRE 1994
Score = 32.0 bits (71), Expect = 0.75
Identities = 43/204 (21%), Positives = 92/204 (45%), Gaps = 16/204 (7%)
Query: 64 AIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERL-GLEKLDLKRQKEQAL 122
A+ + + E+L RE + L Q+AR+ E++ + D + +EQ
Sbjct: 1158 AVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLR 1217
Query: 123 RE---VEHLKRCQQQMAEDKASVKAQVTSLLG---ELQESQSRLE---AATKECQALEGR 173
+E +E ++R +++ E + K + ++ +L +++LE + K+ + G
Sbjct: 1218 QEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGS 1277
Query: 174 RKLAQ----LQVAYHQLFQEYDNHIKSSVVGSERKRADIYKADFQAERQAREKLAEKKEL 229
+ Q L+ Y +L +IK + + R+ + + Q + RE+LAE +
Sbjct: 1278 ESVIQEYVDLRTHYSELTTLTSQYIK-FISETLRRMEEEERLAEQQRAEERERLAEVEAA 1336
Query: 230 LQEQLEQLQREYSKLKASCQESAR 253
L++Q QL +++ KA + A+
Sbjct: 1337 LEKQ-RQLAEAHAQAKAQAEREAK 1359
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 54.7 bits (130), Expect = 1e-07
Identities = 61/235 (25%), Positives = 109/235 (46%), Gaps = 20/235 (8%)
Query: 45 QGAPETLQRCLEENQELR-DAIRQSNQILR-----ERCEELLHFQASQREEKEFLMCKFQ 98
+G E +R EE +E R A R++ Q R ER ++ QA R + + K +
Sbjct: 2217 RGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLR 2276
Query: 99 -EARKLVERLGLEKLDLKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQ 157
EA + R + RQK+ A E+E K+ +Q KA V+ ++T+L +L+E+
Sbjct: 2277 KEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD 2336
Query: 158 SRLEAATKECQALEGRRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRADIYKADFQAER 217
+ +E Q L+ A+ A Q Q + V E + KA +AE
Sbjct: 2337 HQKNLLDEELQRLK-----AEATEAARQRSQVEEELFSVRVQMEELSK---LKARIEAEN 2388
Query: 218 QA---REKLAEKKELLQ--EQLEQLQREYSKLKASCQESARIEDMRKRHVEVSQA 267
+A R+K ++ L + E+++Q+ E ++L + QE+AR+ + + + +A
Sbjct: 2389 RALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRA 2443
Score = 48.5 bits (114), Expect = 8e-06
Identities = 53/223 (23%), Positives = 90/223 (40%), Gaps = 22/223 (9%)
Query: 68 SNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGLEKLDLKRQKEQALREVEH 127
S +++E + H+ +++ + R++ E L + ++E+ L EVE
Sbjct: 1446 SESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERER-LAEVEA 1504
Query: 128 LKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQALEGRRKLAQLQVAYHQLF 187
Q+Q+AE A KAQ ELQ+ E +E A++ +++ +Q QL
Sbjct: 1505 ALEKQRQLAEAHAQAKAQAEREAKELQQRMQE-EVVRREEAAVDAQQQKRSIQEELQQLR 1563
Query: 188 QEYDNHIKSSVVGSE-------RKRADIYKADFQAERQAREK---------LAEKKELLQ 231
Q + I++ +E R +I Q E R++ L + E +
Sbjct: 1564 QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAE 1623
Query: 232 EQLEQLQREYSKLKASCQESARIEDMRKRHVEVSQAPLPPAPA 274
Q Q Q E +L+ Q+ E RKR EV A A A
Sbjct: 1624 AQKRQAQEEAERLRRQVQD----ESQRKRQAEVELASRVKAEA 1662
Score = 46.6 bits (109), Expect = 3e-05
Identities = 51/214 (23%), Positives = 94/214 (43%), Gaps = 20/214 (9%)
Query: 63 DAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGLEKLDLKRQKEQAL 122
D +R Q E + Q + EE+ + +EA + V++ + + RQ++ AL
Sbjct: 2094 DTLRSKEQAELEAARQR---QLAAEEER-----RRREAEERVQKSLAAEEEAARQRKAAL 2145
Query: 123 REVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQALEGRRKLAQLQVA 182
EVE LK ++ + + + L QE+ + A ++ A ++K +LQ
Sbjct: 2146 EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT 2205
Query: 183 YHQLFQEYDNHIKSSVVGSERKRADIYKADFQAERQAREKLAEKKELLQEQLEQLQREYS 242
Q Q + ++ + R + +A QAER+A + + +E E+L+Q E +
Sbjct: 2206 LQQ-EQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEE--AERLKQSAEEQA 2262
Query: 243 KLKASCQESARIEDMRK-------RHVEVSQAPL 269
+ +A Q +A E +RK R + QA L
Sbjct: 2263 QARAQAQAAA--EKLRKEAEQEAARRAQAEQAAL 2294
Score = 45.1 bits (105), Expect = 9e-05
Identities = 49/202 (24%), Positives = 99/202 (49%), Gaps = 33/202 (16%)
Query: 49 ETLQRCLEENQELRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLG 108
E L+ + E + ++ ++Q ++L+ + EE+ Q Q+E+ QE + L +
Sbjct: 2583 ERLREAIAELEREKEKLQQEAKLLQLKSEEM---QTVQQEQL------LQETQALQQSFL 2633
Query: 109 LEKLDLKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQ 168
EK L +++ R +E K +Q+ +D+ + KAQ +L+E Q R + ++
Sbjct: 2634 SEKDSLLQRE----RFIEQEKAKLEQLFQDEVA-KAQ------QLREEQQRQQQQMEQ-- 2680
Query: 169 ALEGRRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRADIYKADFQAERQAREKLAEKKE 228
E +R +A ++ A + + + G RK+ ++ + + Q RQ E LAE+ +
Sbjct: 2681 --ERQRLVASMEEARRRQHEAEE--------GVRRKQEELQQLE-QQRRQQEELLAEENQ 2729
Query: 229 LLQEQLEQLQREYSKLKASCQE 250
L+EQL+ L+ ++ A +E
Sbjct: 2730 RLREQLQLLEEQHRAALAHSEE 2751
Score = 43.5 bits (101), Expect = 2e-04
Identities = 72/313 (23%), Positives = 136/313 (43%), Gaps = 51/313 (16%)
Query: 12 EMVQPSGGPAADQDVLGEESPLGKPAMLHLP------SEQGAPET--LQRCLEENQELRD 63
+ VQ + A+ ++L ++ L + L ++Q A ET QR LE ++ +
Sbjct: 2454 QAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL 2513
Query: 64 AIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGL---EKLDLKR---- 116
+ + L+ R E+ QA E+ + + +E + + R L EK+ L +
Sbjct: 2514 EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2573
Query: 117 QKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQS-RLEAATKECQALEG--- 172
Q++Q+ + E L+ ++ +K ++ + L + +E Q+ + E +E QAL+
Sbjct: 2574 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2633
Query: 173 ---------RRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRADIYKADFQAERQ----- 218
R + Q + QLFQ D K+ + E++R + + ERQ
Sbjct: 2634 SEKDSLLQRERFIEQEKAKLEQLFQ--DEVAKAQQLREEQQRQ---QQQMEQERQRLVAS 2688
Query: 219 ----------AREKLAEKKELLQEQLEQLQREYSKLKASCQESARIEDMRKRHVEVSQAP 268
A E + K+E LQ QLEQ +R+ +L A +E+ R+ + + E +A
Sbjct: 2689 MEEARRRQHEAEEGVRRKQEELQ-QLEQQRRQQEELLA--EENQRLREQLQLLEEQHRAA 2745
Query: 269 LPPAPAYLSSPLA 281
L + +S +A
Sbjct: 2746 LAHSEEVTASQVA 2758
Score = 41.6 bits (96), Expect = 0.001
Identities = 45/194 (23%), Positives = 89/194 (45%), Gaps = 12/194 (6%)
Query: 56 EENQELRDAIRQSNQILRER--CEELLHFQASQREEKEFLMCKFQEARKLVERLGLEKLD 113
E +EL ++N+ LR R EE+ ++ + E E + +EA + R G +
Sbjct: 1763 EAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK---QKEEAEREARRRGKAEEQ 1819
Query: 114 LKRQKEQALREVEHLKR-----CQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQ 168
RQ+E A +E+E ++ QQ++A ++ ++ + + GE Q E A + +
Sbjct: 1820 AVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQRE 1879
Query: 169 ALEGRRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRADIYKADFQAERQAR--EKLAEK 226
A +K +L+ ++ E + + S E R+ K+ + E +A +LAE+
Sbjct: 1880 AAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE 1939
Query: 227 KELLQEQLEQLQRE 240
L+ E+ +R+
Sbjct: 1940 AARLRALAEEAKRQ 1953
Score = 41.2 bits (95), Expect = 0.001
Identities = 70/254 (27%), Positives = 114/254 (44%), Gaps = 33/254 (12%)
Query: 45 QGAPETLQRCLEENQELRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLV 104
Q E +++ EE L A +++ + LR+ EE L A QR E ++ + +A +
Sbjct: 2404 QEEAEKMKQVAEEAARLSVAAQEAAR-LRQLAEEDL---AQQRALAEKMLKEKMQAVQEA 2459
Query: 105 ERLGLEKLDLKRQKE----QALREVEHLKRCQQQMAED----------------KASVKA 144
RL E L++QKE QA R E ++ QQ+AE+ + S +A
Sbjct: 2460 TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEA 2519
Query: 145 QVTSL-LGELQESQSRLE--AATKECQALEGRRKLAQLQVAYHQ---LFQEYDNHIKSSV 198
+ L + E+ +Q+R E A QA E KL + ++A + L Q + + S
Sbjct: 2520 ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSD 2579
Query: 199 VGSERKRADIYKADFQAER-QAREKLAEKK--ELLQEQLEQLQREYSKLKASCQESARIE 255
+ER R I + + + E+ Q KL + K E+ Q EQL +E L+ S
Sbjct: 2580 HDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL 2639
Query: 256 DMRKRHVEVSQAPL 269
R+R +E +A L
Sbjct: 2640 LQRERFIEQEKAKL 2653
Score = 40.8 bits (94), Expect = 0.002
Identities = 54/252 (21%), Positives = 103/252 (40%), Gaps = 34/252 (13%)
Query: 29 EESPLGKPAMLHLPS----EQGAPETLQRCLEENQELR----DAIRQSNQILRERCEEL- 79
+ES + A + L S E A QR L+ +ELR +A R+ Q ER ++
Sbjct: 1642 DESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQ 1701
Query: 80 LHFQASQREEKEFLMCK---------------------FQEARKLVERLGLEKLDLKRQK 118
+ + +QR + L K + R+ ER ++ + +R +
Sbjct: 1702 VALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAR 1761
Query: 119 EQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQALEGRRKLAQ 178
E+A RE+E Q A + ++ Q + + +Q+ E +E + RR A+
Sbjct: 1762 EEAERELERW----QLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAE 1817
Query: 179 LQVAYHQLFQEYDNHIKSSVVGSERKRADIYKADFQAERQAREKLAEKKELLQEQLEQLQ 238
Q + E + + + ++ + + R E+ ++++LL+E+L +LQ
Sbjct: 1818 EQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQ 1877
Query: 239 REYSKLKASCQE 250
RE + QE
Sbjct: 1878 REAAAATQKRQE 1889
Score = 36.2 bits (82), Expect = 0.040
Identities = 49/216 (22%), Positives = 95/216 (43%), Gaps = 24/216 (11%)
Query: 44 EQGAPETLQRCLEENQELRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKL 103
++ A Q+ E EL + +L + +++ + K+ L + R+L
Sbjct: 1877 QREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL 1936
Query: 104 VE---RLGLEKLDLKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRL 160
E RL + KRQ++ A + +Q AE + V A+ + +GE ++
Sbjct: 1937 AEEAARLRALAEEAKRQRQLAEED------AARQRAEAE-RVLAEKLAAIGEATRLKTEA 1989
Query: 161 EAATKECQALEGR-RKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRADIYKADFQAERQA 219
E A KE +A R R+LA+ + + +E + + +ADI + Q + +
Sbjct: 1990 EIALKEKEAENERLRRLAEDEAFQRRRLEEQ----------AAQHKADIEERLAQLRKAS 2039
Query: 220 REKLAEKKELLQE---QLEQLQREYSKLKASCQESA 252
+L +K L+++ Q Q++ E LKAS +++A
Sbjct: 2040 DSELERQKGLVEDTLRQRRQVEEEILALKASFEKAA 2075
Score = 35.0 bits (79), Expect = 0.089
Identities = 39/204 (19%), Positives = 83/204 (40%), Gaps = 10/204 (4%)
Query: 56 EENQELRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEA---RKLVERLGLEKL 112
E + L + + + R + E + + + E + EA R+L E+ K
Sbjct: 1967 EAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA 2026
Query: 113 DLKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQALEG 172
D++ + Q + + Q+ + ED + QV + L+ S + A E + G
Sbjct: 2027 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 2086
Query: 173 RRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRADIYKADFQAERQAREKLAEKKELLQE 232
R + + E + + + E +R +AE + ++ LA ++E ++
Sbjct: 2087 RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRR------EAEERVQKSLAAEEEAARQ 2140
Query: 233 QLEQLQREYSKLKASCQESARIED 256
+ L+ E +LKA +E+ R+ +
Sbjct: 2141 RKAALE-EVERLKAKVEEARRLRE 2163
Score = 32.0 bits (71), Expect = 0.75
Identities = 43/204 (21%), Positives = 92/204 (45%), Gaps = 16/204 (7%)
Query: 64 AIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERL-GLEKLDLKRQKEQAL 122
A+ + + E+L RE + L Q+AR+ E++ + D + +EQ
Sbjct: 1327 AVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLR 1386
Query: 123 RE---VEHLKRCQQQMAEDKASVKAQVTSLLG---ELQESQSRLE---AATKECQALEGR 173
+E +E ++R +++ E + K + ++ +L +++LE + K+ + G
Sbjct: 1387 QEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGS 1446
Query: 174 RKLAQ----LQVAYHQLFQEYDNHIKSSVVGSERKRADIYKADFQAERQAREKLAEKKEL 229
+ Q L+ Y +L +IK + + R+ + + Q + RE+LAE +
Sbjct: 1447 ESVIQEYVDLRTHYSELTTLTSQYIK-FISETLRRMEEEERLAEQQRAEERERLAEVEAA 1505
Query: 230 LQEQLEQLQREYSKLKASCQESAR 253
L++Q QL +++ KA + A+
Sbjct: 1506 LEKQ-RQLAEAHAQAKAQAEREAK 1528
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 54.7 bits (130), Expect = 1e-07
Identities = 61/235 (25%), Positives = 109/235 (46%), Gaps = 20/235 (8%)
Query: 45 QGAPETLQRCLEENQELR-DAIRQSNQILR-----ERCEELLHFQASQREEKEFLMCKFQ 98
+G E +R EE +E R A R++ Q R ER ++ QA R + + K +
Sbjct: 2058 RGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLR 2117
Query: 99 -EARKLVERLGLEKLDLKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQ 157
EA + R + RQK+ A E+E K+ +Q KA V+ ++T+L +L+E+
Sbjct: 2118 KEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD 2177
Query: 158 SRLEAATKECQALEGRRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRADIYKADFQAER 217
+ +E Q L+ A+ A Q Q + V E + KA +AE
Sbjct: 2178 HQKNLLDEELQRLK-----AEATEAARQRSQVEEELFSVRVQMEELSK---LKARIEAEN 2229
Query: 218 QA---REKLAEKKELLQ--EQLEQLQREYSKLKASCQESARIEDMRKRHVEVSQA 267
+A R+K ++ L + E+++Q+ E ++L + QE+AR+ + + + +A
Sbjct: 2230 RALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRA 2284
Score = 48.5 bits (114), Expect = 8e-06
Identities = 53/223 (23%), Positives = 90/223 (40%), Gaps = 22/223 (9%)
Query: 68 SNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGLEKLDLKRQKEQALREVEH 127
S +++E + H+ +++ + R++ E L + ++E+ L EVE
Sbjct: 1287 SESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERER-LAEVEA 1345
Query: 128 LKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQALEGRRKLAQLQVAYHQLF 187
Q+Q+AE A KAQ ELQ+ E +E A++ +++ +Q QL
Sbjct: 1346 ALEKQRQLAEAHAQAKAQAEREAKELQQRMQE-EVVRREEAAVDAQQQKRSIQEELQQLR 1404
Query: 188 QEYDNHIKSSVVGSE-------RKRADIYKADFQAERQAREK---------LAEKKELLQ 231
Q + I++ +E R +I Q E R++ L + E +
Sbjct: 1405 QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAE 1464
Query: 232 EQLEQLQREYSKLKASCQESARIEDMRKRHVEVSQAPLPPAPA 274
Q Q Q E +L+ Q+ E RKR EV A A A
Sbjct: 1465 AQKRQAQEEAERLRRQVQD----ESQRKRQAEVELASRVKAEA 1503
Score = 46.6 bits (109), Expect = 3e-05
Identities = 51/214 (23%), Positives = 94/214 (43%), Gaps = 20/214 (9%)
Query: 63 DAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGLEKLDLKRQKEQAL 122
D +R Q E + Q + EE+ + +EA + V++ + + RQ++ AL
Sbjct: 1935 DTLRSKEQAELEAARQR---QLAAEEER-----RRREAEERVQKSLAAEEEAARQRKAAL 1986
Query: 123 REVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQALEGRRKLAQLQVA 182
EVE LK ++ + + + L QE+ + A ++ A ++K +LQ
Sbjct: 1987 EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT 2046
Query: 183 YHQLFQEYDNHIKSSVVGSERKRADIYKADFQAERQAREKLAEKKELLQEQLEQLQREYS 242
Q Q + ++ + R + +A QAER+A + + +E E+L+Q E +
Sbjct: 2047 LQQ-EQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEE--AERLKQSAEEQA 2103
Query: 243 KLKASCQESARIEDMRK-------RHVEVSQAPL 269
+ +A Q +A E +RK R + QA L
Sbjct: 2104 QARAQAQAAA--EKLRKEAEQEAARRAQAEQAAL 2135
Score = 45.1 bits (105), Expect = 9e-05
Identities = 49/202 (24%), Positives = 99/202 (49%), Gaps = 33/202 (16%)
Query: 49 ETLQRCLEENQELRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLG 108
E L+ + E + ++ ++Q ++L+ + EE+ Q Q+E+ QE + L +
Sbjct: 2424 ERLREAIAELEREKEKLQQEAKLLQLKSEEM---QTVQQEQL------LQETQALQQSFL 2474
Query: 109 LEKLDLKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQ 168
EK L +++ R +E K +Q+ +D+ + KAQ +L+E Q R + ++
Sbjct: 2475 SEKDSLLQRE----RFIEQEKAKLEQLFQDEVA-KAQ------QLREEQQRQQQQMEQ-- 2521
Query: 169 ALEGRRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRADIYKADFQAERQAREKLAEKKE 228
E +R +A ++ A + + + G RK+ ++ + + Q RQ E LAE+ +
Sbjct: 2522 --ERQRLVASMEEARRRQHEAEE--------GVRRKQEELQQLE-QQRRQQEELLAEENQ 2570
Query: 229 LLQEQLEQLQREYSKLKASCQE 250
L+EQL+ L+ ++ A +E
Sbjct: 2571 RLREQLQLLEEQHRAALAHSEE 2592
Score = 43.5 bits (101), Expect = 2e-04
Identities = 72/313 (23%), Positives = 136/313 (43%), Gaps = 51/313 (16%)
Query: 12 EMVQPSGGPAADQDVLGEESPLGKPAMLHLP------SEQGAPET--LQRCLEENQELRD 63
+ VQ + A+ ++L ++ L + L ++Q A ET QR LE ++ +
Sbjct: 2295 QAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL 2354
Query: 64 AIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGL---EKLDLKR---- 116
+ + L+ R E+ QA E+ + + +E + + R L EK+ L +
Sbjct: 2355 EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2414
Query: 117 QKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQS-RLEAATKECQALEG--- 172
Q++Q+ + E L+ ++ +K ++ + L + +E Q+ + E +E QAL+
Sbjct: 2415 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2474
Query: 173 ---------RRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRADIYKADFQAERQ----- 218
R + Q + QLFQ D K+ + E++R + + ERQ
Sbjct: 2475 SEKDSLLQRERFIEQEKAKLEQLFQ--DEVAKAQQLREEQQRQ---QQQMEQERQRLVAS 2529
Query: 219 ----------AREKLAEKKELLQEQLEQLQREYSKLKASCQESARIEDMRKRHVEVSQAP 268
A E + K+E LQ QLEQ +R+ +L A +E+ R+ + + E +A
Sbjct: 2530 MEEARRRQHEAEEGVRRKQEELQ-QLEQQRRQQEELLA--EENQRLREQLQLLEEQHRAA 2586
Query: 269 LPPAPAYLSSPLA 281
L + +S +A
Sbjct: 2587 LAHSEEVTASQVA 2599
Score = 41.6 bits (96), Expect = 0.001
Identities = 45/194 (23%), Positives = 89/194 (45%), Gaps = 12/194 (6%)
Query: 56 EENQELRDAIRQSNQILRER--CEELLHFQASQREEKEFLMCKFQEARKLVERLGLEKLD 113
E +EL ++N+ LR R EE+ ++ + E E + +EA + R G +
Sbjct: 1604 EAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK---QKEEAEREARRRGKAEEQ 1660
Query: 114 LKRQKEQALREVEHLKR-----CQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQ 168
RQ+E A +E+E ++ QQ++A ++ ++ + + GE Q E A + +
Sbjct: 1661 AVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQRE 1720
Query: 169 ALEGRRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRADIYKADFQAERQAR--EKLAEK 226
A +K +L+ ++ E + + S E R+ K+ + E +A +LAE+
Sbjct: 1721 AAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE 1780
Query: 227 KELLQEQLEQLQRE 240
L+ E+ +R+
Sbjct: 1781 AARLRALAEEAKRQ 1794
Score = 41.2 bits (95), Expect = 0.001
Identities = 70/254 (27%), Positives = 114/254 (44%), Gaps = 33/254 (12%)
Query: 45 QGAPETLQRCLEENQELRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLV 104
Q E +++ EE L A +++ + LR+ EE L A QR E ++ + +A +
Sbjct: 2245 QEEAEKMKQVAEEAARLSVAAQEAAR-LRQLAEEDL---AQQRALAEKMLKEKMQAVQEA 2300
Query: 105 ERLGLEKLDLKRQKE----QALREVEHLKRCQQQMAED----------------KASVKA 144
RL E L++QKE QA R E ++ QQ+AE+ + S +A
Sbjct: 2301 TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEA 2360
Query: 145 QVTSL-LGELQESQSRLE--AATKECQALEGRRKLAQLQVAYHQ---LFQEYDNHIKSSV 198
+ L + E+ +Q+R E A QA E KL + ++A + L Q + + S
Sbjct: 2361 ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSD 2420
Query: 199 VGSERKRADIYKADFQAER-QAREKLAEKK--ELLQEQLEQLQREYSKLKASCQESARIE 255
+ER R I + + + E+ Q KL + K E+ Q EQL +E L+ S
Sbjct: 2421 HDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL 2480
Query: 256 DMRKRHVEVSQAPL 269
R+R +E +A L
Sbjct: 2481 LQRERFIEQEKAKL 2494
Score = 40.8 bits (94), Expect = 0.002
Identities = 54/252 (21%), Positives = 103/252 (40%), Gaps = 34/252 (13%)
Query: 29 EESPLGKPAMLHLPS----EQGAPETLQRCLEENQELR----DAIRQSNQILRERCEEL- 79
+ES + A + L S E A QR L+ +ELR +A R+ Q ER ++
Sbjct: 1483 DESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQ 1542
Query: 80 LHFQASQREEKEFLMCK---------------------FQEARKLVERLGLEKLDLKRQK 118
+ + +QR + L K + R+ ER ++ + +R +
Sbjct: 1543 VALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAR 1602
Query: 119 EQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQALEGRRKLAQ 178
E+A RE+E Q A + ++ Q + + +Q+ E +E + RR A+
Sbjct: 1603 EEAERELERW----QLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAE 1658
Query: 179 LQVAYHQLFQEYDNHIKSSVVGSERKRADIYKADFQAERQAREKLAEKKELLQEQLEQLQ 238
Q + E + + + ++ + + R E+ ++++LL+E+L +LQ
Sbjct: 1659 EQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQ 1718
Query: 239 REYSKLKASCQE 250
RE + QE
Sbjct: 1719 REAAAATQKRQE 1730
Score = 36.2 bits (82), Expect = 0.040
Identities = 49/216 (22%), Positives = 95/216 (43%), Gaps = 24/216 (11%)
Query: 44 EQGAPETLQRCLEENQELRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKL 103
++ A Q+ E EL + +L + +++ + K+ L + R+L
Sbjct: 1718 QREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL 1777
Query: 104 VE---RLGLEKLDLKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRL 160
E RL + KRQ++ A + +Q AE + V A+ + +GE ++
Sbjct: 1778 AEEAARLRALAEEAKRQRQLAEED------AARQRAEAE-RVLAEKLAAIGEATRLKTEA 1830
Query: 161 EAATKECQALEGR-RKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRADIYKADFQAERQA 219
E A KE +A R R+LA+ + + +E + + +ADI + Q + +
Sbjct: 1831 EIALKEKEAENERLRRLAEDEAFQRRRLEEQ----------AAQHKADIEERLAQLRKAS 1880
Query: 220 REKLAEKKELLQE---QLEQLQREYSKLKASCQESA 252
+L +K L+++ Q Q++ E LKAS +++A
Sbjct: 1881 DSELERQKGLVEDTLRQRRQVEEEILALKASFEKAA 1916
Score = 35.0 bits (79), Expect = 0.089
Identities = 39/204 (19%), Positives = 83/204 (40%), Gaps = 10/204 (4%)
Query: 56 EENQELRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEA---RKLVERLGLEKL 112
E + L + + + R + E + + + E + EA R+L E+ K
Sbjct: 1808 EAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA 1867
Query: 113 DLKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQALEG 172
D++ + Q + + Q+ + ED + QV + L+ S + A E + G
Sbjct: 1868 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 1927
Query: 173 RRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRADIYKADFQAERQAREKLAEKKELLQE 232
R + + E + + + E +R +AE + ++ LA ++E ++
Sbjct: 1928 RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRR------EAEERVQKSLAAEEEAARQ 1981
Query: 233 QLEQLQREYSKLKASCQESARIED 256
+ L+ E +LKA +E+ R+ +
Sbjct: 1982 RKAALE-EVERLKAKVEEARRLRE 2004
Score = 32.0 bits (71), Expect = 0.75
Identities = 43/204 (21%), Positives = 92/204 (45%), Gaps = 16/204 (7%)
Query: 64 AIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERL-GLEKLDLKRQKEQAL 122
A+ + + E+L RE + L Q+AR+ E++ + D + +EQ
Sbjct: 1168 AVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLR 1227
Query: 123 RE---VEHLKRCQQQMAEDKASVKAQVTSLLG---ELQESQSRLE---AATKECQALEGR 173
+E +E ++R +++ E + K + ++ +L +++LE + K+ + G
Sbjct: 1228 QEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGS 1287
Query: 174 RKLAQ----LQVAYHQLFQEYDNHIKSSVVGSERKRADIYKADFQAERQAREKLAEKKEL 229
+ Q L+ Y +L +IK + + R+ + + Q + RE+LAE +
Sbjct: 1288 ESVIQEYVDLRTHYSELTTLTSQYIK-FISETLRRMEEEERLAEQQRAEERERLAEVEAA 1346
Query: 230 LQEQLEQLQREYSKLKASCQESAR 253
L++Q QL +++ KA + A+
Sbjct: 1347 LEKQ-RQLAEAHAQAKAQAEREAK 1369
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 54.7 bits (130), Expect = 1e-07
Identities = 61/235 (25%), Positives = 109/235 (46%), Gaps = 20/235 (8%)
Query: 45 QGAPETLQRCLEENQELR-DAIRQSNQILR-----ERCEELLHFQASQREEKEFLMCKFQ 98
+G E +R EE +E R A R++ Q R ER ++ QA R + + K +
Sbjct: 2066 RGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLR 2125
Query: 99 -EARKLVERLGLEKLDLKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQ 157
EA + R + RQK+ A E+E K+ +Q KA V+ ++T+L +L+E+
Sbjct: 2126 KEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD 2185
Query: 158 SRLEAATKECQALEGRRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRADIYKADFQAER 217
+ +E Q L+ A+ A Q Q + V E + KA +AE
Sbjct: 2186 HQKNLLDEELQRLK-----AEATEAARQRSQVEEELFSVRVQMEELSK---LKARIEAEN 2237
Query: 218 QA---REKLAEKKELLQ--EQLEQLQREYSKLKASCQESARIEDMRKRHVEVSQA 267
+A R+K ++ L + E+++Q+ E ++L + QE+AR+ + + + +A
Sbjct: 2238 RALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRA 2292
Score = 48.5 bits (114), Expect = 8e-06
Identities = 53/223 (23%), Positives = 90/223 (40%), Gaps = 22/223 (9%)
Query: 68 SNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGLEKLDLKRQKEQALREVEH 127
S +++E + H+ +++ + R++ E L + ++E+ L EVE
Sbjct: 1295 SESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERER-LAEVEA 1353
Query: 128 LKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQALEGRRKLAQLQVAYHQLF 187
Q+Q+AE A KAQ ELQ+ E +E A++ +++ +Q QL
Sbjct: 1354 ALEKQRQLAEAHAQAKAQAEREAKELQQRMQE-EVVRREEAAVDAQQQKRSIQEELQQLR 1412
Query: 188 QEYDNHIKSSVVGSE-------RKRADIYKADFQAERQAREK---------LAEKKELLQ 231
Q + I++ +E R +I Q E R++ L + E +
Sbjct: 1413 QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAE 1472
Query: 232 EQLEQLQREYSKLKASCQESARIEDMRKRHVEVSQAPLPPAPA 274
Q Q Q E +L+ Q+ E RKR EV A A A
Sbjct: 1473 AQKRQAQEEAERLRRQVQD----ESQRKRQAEVELASRVKAEA 1511
Score = 46.6 bits (109), Expect = 3e-05
Identities = 51/214 (23%), Positives = 94/214 (43%), Gaps = 20/214 (9%)
Query: 63 DAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGLEKLDLKRQKEQAL 122
D +R Q E + Q + EE+ + +EA + V++ + + RQ++ AL
Sbjct: 1943 DTLRSKEQAELEAARQR---QLAAEEER-----RRREAEERVQKSLAAEEEAARQRKAAL 1994
Query: 123 REVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQALEGRRKLAQLQVA 182
EVE LK ++ + + + L QE+ + A ++ A ++K +LQ
Sbjct: 1995 EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT 2054
Query: 183 YHQLFQEYDNHIKSSVVGSERKRADIYKADFQAERQAREKLAEKKELLQEQLEQLQREYS 242
Q Q + ++ + R + +A QAER+A + + +E E+L+Q E +
Sbjct: 2055 LQQ-EQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEE--AERLKQSAEEQA 2111
Query: 243 KLKASCQESARIEDMRK-------RHVEVSQAPL 269
+ +A Q +A E +RK R + QA L
Sbjct: 2112 QARAQAQAAA--EKLRKEAEQEAARRAQAEQAAL 2143
Score = 45.1 bits (105), Expect = 9e-05
Identities = 49/202 (24%), Positives = 99/202 (49%), Gaps = 33/202 (16%)
Query: 49 ETLQRCLEENQELRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLG 108
E L+ + E + ++ ++Q ++L+ + EE+ Q Q+E+ QE + L +
Sbjct: 2432 ERLREAIAELEREKEKLQQEAKLLQLKSEEM---QTVQQEQL------LQETQALQQSFL 2482
Query: 109 LEKLDLKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQ 168
EK L +++ R +E K +Q+ +D+ + KAQ +L+E Q R + ++
Sbjct: 2483 SEKDSLLQRE----RFIEQEKAKLEQLFQDEVA-KAQ------QLREEQQRQQQQMEQ-- 2529
Query: 169 ALEGRRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRADIYKADFQAERQAREKLAEKKE 228
E +R +A ++ A + + + G RK+ ++ + + Q RQ E LAE+ +
Sbjct: 2530 --ERQRLVASMEEARRRQHEAEE--------GVRRKQEELQQLE-QQRRQQEELLAEENQ 2578
Query: 229 LLQEQLEQLQREYSKLKASCQE 250
L+EQL+ L+ ++ A +E
Sbjct: 2579 RLREQLQLLEEQHRAALAHSEE 2600
Score = 43.5 bits (101), Expect = 2e-04
Identities = 72/313 (23%), Positives = 136/313 (43%), Gaps = 51/313 (16%)
Query: 12 EMVQPSGGPAADQDVLGEESPLGKPAMLHLP------SEQGAPET--LQRCLEENQELRD 63
+ VQ + A+ ++L ++ L + L ++Q A ET QR LE ++ +
Sbjct: 2303 QAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL 2362
Query: 64 AIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGL---EKLDLKR---- 116
+ + L+ R E+ QA E+ + + +E + + R L EK+ L +
Sbjct: 2363 EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2422
Query: 117 QKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQS-RLEAATKECQALEG--- 172
Q++Q+ + E L+ ++ +K ++ + L + +E Q+ + E +E QAL+
Sbjct: 2423 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2482
Query: 173 ---------RRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRADIYKADFQAERQ----- 218
R + Q + QLFQ D K+ + E++R + + ERQ
Sbjct: 2483 SEKDSLLQRERFIEQEKAKLEQLFQ--DEVAKAQQLREEQQRQ---QQQMEQERQRLVAS 2537
Query: 219 ----------AREKLAEKKELLQEQLEQLQREYSKLKASCQESARIEDMRKRHVEVSQAP 268
A E + K+E LQ QLEQ +R+ +L A +E+ R+ + + E +A
Sbjct: 2538 MEEARRRQHEAEEGVRRKQEELQ-QLEQQRRQQEELLA--EENQRLREQLQLLEEQHRAA 2594
Query: 269 LPPAPAYLSSPLA 281
L + +S +A
Sbjct: 2595 LAHSEEVTASQVA 2607
Score = 41.6 bits (96), Expect = 0.001
Identities = 45/194 (23%), Positives = 89/194 (45%), Gaps = 12/194 (6%)
Query: 56 EENQELRDAIRQSNQILRER--CEELLHFQASQREEKEFLMCKFQEARKLVERLGLEKLD 113
E +EL ++N+ LR R EE+ ++ + E E + +EA + R G +
Sbjct: 1612 EAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK---QKEEAEREARRRGKAEEQ 1668
Query: 114 LKRQKEQALREVEHLKR-----CQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQ 168
RQ+E A +E+E ++ QQ++A ++ ++ + + GE Q E A + +
Sbjct: 1669 AVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQRE 1728
Query: 169 ALEGRRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRADIYKADFQAERQAR--EKLAEK 226
A +K +L+ ++ E + + S E R+ K+ + E +A +LAE+
Sbjct: 1729 AAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE 1788
Query: 227 KELLQEQLEQLQRE 240
L+ E+ +R+
Sbjct: 1789 AARLRALAEEAKRQ 1802
Score = 41.2 bits (95), Expect = 0.001
Identities = 70/254 (27%), Positives = 114/254 (44%), Gaps = 33/254 (12%)
Query: 45 QGAPETLQRCLEENQELRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLV 104
Q E +++ EE L A +++ + LR+ EE L A QR E ++ + +A +
Sbjct: 2253 QEEAEKMKQVAEEAARLSVAAQEAAR-LRQLAEEDL---AQQRALAEKMLKEKMQAVQEA 2308
Query: 105 ERLGLEKLDLKRQKE----QALREVEHLKRCQQQMAED----------------KASVKA 144
RL E L++QKE QA R E ++ QQ+AE+ + S +A
Sbjct: 2309 TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEA 2368
Query: 145 QVTSL-LGELQESQSRLE--AATKECQALEGRRKLAQLQVAYHQ---LFQEYDNHIKSSV 198
+ L + E+ +Q+R E A QA E KL + ++A + L Q + + S
Sbjct: 2369 ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSD 2428
Query: 199 VGSERKRADIYKADFQAER-QAREKLAEKK--ELLQEQLEQLQREYSKLKASCQESARIE 255
+ER R I + + + E+ Q KL + K E+ Q EQL +E L+ S
Sbjct: 2429 HDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL 2488
Query: 256 DMRKRHVEVSQAPL 269
R+R +E +A L
Sbjct: 2489 LQRERFIEQEKAKL 2502
Score = 40.8 bits (94), Expect = 0.002
Identities = 54/252 (21%), Positives = 103/252 (40%), Gaps = 34/252 (13%)
Query: 29 EESPLGKPAMLHLPS----EQGAPETLQRCLEENQELR----DAIRQSNQILRERCEEL- 79
+ES + A + L S E A QR L+ +ELR +A R+ Q ER ++
Sbjct: 1491 DESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQ 1550
Query: 80 LHFQASQREEKEFLMCK---------------------FQEARKLVERLGLEKLDLKRQK 118
+ + +QR + L K + R+ ER ++ + +R +
Sbjct: 1551 VALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAR 1610
Query: 119 EQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQALEGRRKLAQ 178
E+A RE+E Q A + ++ Q + + +Q+ E +E + RR A+
Sbjct: 1611 EEAERELERW----QLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAE 1666
Query: 179 LQVAYHQLFQEYDNHIKSSVVGSERKRADIYKADFQAERQAREKLAEKKELLQEQLEQLQ 238
Q + E + + + ++ + + R E+ ++++LL+E+L +LQ
Sbjct: 1667 EQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQ 1726
Query: 239 REYSKLKASCQE 250
RE + QE
Sbjct: 1727 REAAAATQKRQE 1738
Score = 36.2 bits (82), Expect = 0.040
Identities = 49/216 (22%), Positives = 95/216 (43%), Gaps = 24/216 (11%)
Query: 44 EQGAPETLQRCLEENQELRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKL 103
++ A Q+ E EL + +L + +++ + K+ L + R+L
Sbjct: 1726 QREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL 1785
Query: 104 VE---RLGLEKLDLKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRL 160
E RL + KRQ++ A + +Q AE + V A+ + +GE ++
Sbjct: 1786 AEEAARLRALAEEAKRQRQLAEED------AARQRAEAE-RVLAEKLAAIGEATRLKTEA 1838
Query: 161 EAATKECQALEGR-RKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRADIYKADFQAERQA 219
E A KE +A R R+LA+ + + +E + + +ADI + Q + +
Sbjct: 1839 EIALKEKEAENERLRRLAEDEAFQRRRLEEQ----------AAQHKADIEERLAQLRKAS 1888
Query: 220 REKLAEKKELLQE---QLEQLQREYSKLKASCQESA 252
+L +K L+++ Q Q++ E LKAS +++A
Sbjct: 1889 DSELERQKGLVEDTLRQRRQVEEEILALKASFEKAA 1924
Score = 35.0 bits (79), Expect = 0.089
Identities = 39/204 (19%), Positives = 83/204 (40%), Gaps = 10/204 (4%)
Query: 56 EENQELRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEA---RKLVERLGLEKL 112
E + L + + + R + E + + + E + EA R+L E+ K
Sbjct: 1816 EAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA 1875
Query: 113 DLKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQALEG 172
D++ + Q + + Q+ + ED + QV + L+ S + A E + G
Sbjct: 1876 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 1935
Query: 173 RRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRADIYKADFQAERQAREKLAEKKELLQE 232
R + + E + + + E +R +AE + ++ LA ++E ++
Sbjct: 1936 RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRR------EAEERVQKSLAAEEEAARQ 1989
Query: 233 QLEQLQREYSKLKASCQESARIED 256
+ L+ E +LKA +E+ R+ +
Sbjct: 1990 RKAALE-EVERLKAKVEEARRLRE 2012
Score = 32.0 bits (71), Expect = 0.75
Identities = 43/204 (21%), Positives = 92/204 (45%), Gaps = 16/204 (7%)
Query: 64 AIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERL-GLEKLDLKRQKEQAL 122
A+ + + E+L RE + L Q+AR+ E++ + D + +EQ
Sbjct: 1176 AVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLR 1235
Query: 123 RE---VEHLKRCQQQMAEDKASVKAQVTSLLG---ELQESQSRLE---AATKECQALEGR 173
+E +E ++R +++ E + K + ++ +L +++LE + K+ + G
Sbjct: 1236 QEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGS 1295
Query: 174 RKLAQ----LQVAYHQLFQEYDNHIKSSVVGSERKRADIYKADFQAERQAREKLAEKKEL 229
+ Q L+ Y +L +IK + + R+ + + Q + RE+LAE +
Sbjct: 1296 ESVIQEYVDLRTHYSELTTLTSQYIK-FISETLRRMEEEERLAEQQRAEERERLAEVEAA 1354
Query: 230 LQEQLEQLQREYSKLKASCQESAR 253
L++Q QL +++ KA + A+
Sbjct: 1355 LEKQ-RQLAEAHAQAKAQAEREAK 1377
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 54.7 bits (130), Expect = 1e-07
Identities = 61/235 (25%), Positives = 109/235 (46%), Gaps = 20/235 (8%)
Query: 45 QGAPETLQRCLEENQELR-DAIRQSNQILR-----ERCEELLHFQASQREEKEFLMCKFQ 98
+G E +R EE +E R A R++ Q R ER ++ QA R + + K +
Sbjct: 2107 RGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLR 2166
Query: 99 -EARKLVERLGLEKLDLKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQ 157
EA + R + RQK+ A E+E K+ +Q KA V+ ++T+L +L+E+
Sbjct: 2167 KEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD 2226
Query: 158 SRLEAATKECQALEGRRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRADIYKADFQAER 217
+ +E Q L+ A+ A Q Q + V E + KA +AE
Sbjct: 2227 HQKNLLDEELQRLK-----AEATEAARQRSQVEEELFSVRVQMEELSK---LKARIEAEN 2278
Query: 218 QA---REKLAEKKELLQ--EQLEQLQREYSKLKASCQESARIEDMRKRHVEVSQA 267
+A R+K ++ L + E+++Q+ E ++L + QE+AR+ + + + +A
Sbjct: 2279 RALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRA 2333
Score = 48.5 bits (114), Expect = 8e-06
Identities = 53/223 (23%), Positives = 90/223 (40%), Gaps = 22/223 (9%)
Query: 68 SNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGLEKLDLKRQKEQALREVEH 127
S +++E + H+ +++ + R++ E L + ++E+ L EVE
Sbjct: 1336 SESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERER-LAEVEA 1394
Query: 128 LKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQALEGRRKLAQLQVAYHQLF 187
Q+Q+AE A KAQ ELQ+ E +E A++ +++ +Q QL
Sbjct: 1395 ALEKQRQLAEAHAQAKAQAEREAKELQQRMQE-EVVRREEAAVDAQQQKRSIQEELQQLR 1453
Query: 188 QEYDNHIKSSVVGSE-------RKRADIYKADFQAERQAREK---------LAEKKELLQ 231
Q + I++ +E R +I Q E R++ L + E +
Sbjct: 1454 QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAE 1513
Query: 232 EQLEQLQREYSKLKASCQESARIEDMRKRHVEVSQAPLPPAPA 274
Q Q Q E +L+ Q+ E RKR EV A A A
Sbjct: 1514 AQKRQAQEEAERLRRQVQD----ESQRKRQAEVELASRVKAEA 1552
Score = 46.6 bits (109), Expect = 3e-05
Identities = 51/214 (23%), Positives = 94/214 (43%), Gaps = 20/214 (9%)
Query: 63 DAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGLEKLDLKRQKEQAL 122
D +R Q E + Q + EE+ + +EA + V++ + + RQ++ AL
Sbjct: 1984 DTLRSKEQAELEAARQR---QLAAEEER-----RRREAEERVQKSLAAEEEAARQRKAAL 2035
Query: 123 REVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQALEGRRKLAQLQVA 182
EVE LK ++ + + + L QE+ + A ++ A ++K +LQ
Sbjct: 2036 EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT 2095
Query: 183 YHQLFQEYDNHIKSSVVGSERKRADIYKADFQAERQAREKLAEKKELLQEQLEQLQREYS 242
Q Q + ++ + R + +A QAER+A + + +E E+L+Q E +
Sbjct: 2096 LQQ-EQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEE--AERLKQSAEEQA 2152
Query: 243 KLKASCQESARIEDMRK-------RHVEVSQAPL 269
+ +A Q +A E +RK R + QA L
Sbjct: 2153 QARAQAQAAA--EKLRKEAEQEAARRAQAEQAAL 2184
Score = 45.1 bits (105), Expect = 9e-05
Identities = 49/202 (24%), Positives = 99/202 (49%), Gaps = 33/202 (16%)
Query: 49 ETLQRCLEENQELRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLG 108
E L+ + E + ++ ++Q ++L+ + EE+ Q Q+E+ QE + L +
Sbjct: 2473 ERLREAIAELEREKEKLQQEAKLLQLKSEEM---QTVQQEQL------LQETQALQQSFL 2523
Query: 109 LEKLDLKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQ 168
EK L +++ R +E K +Q+ +D+ + KAQ +L+E Q R + ++
Sbjct: 2524 SEKDSLLQRE----RFIEQEKAKLEQLFQDEVA-KAQ------QLREEQQRQQQQMEQ-- 2570
Query: 169 ALEGRRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRADIYKADFQAERQAREKLAEKKE 228
E +R +A ++ A + + + G RK+ ++ + + Q RQ E LAE+ +
Sbjct: 2571 --ERQRLVASMEEARRRQHEAEE--------GVRRKQEELQQLE-QQRRQQEELLAEENQ 2619
Query: 229 LLQEQLEQLQREYSKLKASCQE 250
L+EQL+ L+ ++ A +E
Sbjct: 2620 RLREQLQLLEEQHRAALAHSEE 2641
Score = 43.5 bits (101), Expect = 2e-04
Identities = 72/313 (23%), Positives = 136/313 (43%), Gaps = 51/313 (16%)
Query: 12 EMVQPSGGPAADQDVLGEESPLGKPAMLHLP------SEQGAPET--LQRCLEENQELRD 63
+ VQ + A+ ++L ++ L + L ++Q A ET QR LE ++ +
Sbjct: 2344 QAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL 2403
Query: 64 AIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGL---EKLDLKR---- 116
+ + L+ R E+ QA E+ + + +E + + R L EK+ L +
Sbjct: 2404 EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2463
Query: 117 QKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQS-RLEAATKECQALEG--- 172
Q++Q+ + E L+ ++ +K ++ + L + +E Q+ + E +E QAL+
Sbjct: 2464 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2523
Query: 173 ---------RRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRADIYKADFQAERQ----- 218
R + Q + QLFQ D K+ + E++R + + ERQ
Sbjct: 2524 SEKDSLLQRERFIEQEKAKLEQLFQ--DEVAKAQQLREEQQRQ---QQQMEQERQRLVAS 2578
Query: 219 ----------AREKLAEKKELLQEQLEQLQREYSKLKASCQESARIEDMRKRHVEVSQAP 268
A E + K+E LQ QLEQ +R+ +L A +E+ R+ + + E +A
Sbjct: 2579 MEEARRRQHEAEEGVRRKQEELQ-QLEQQRRQQEELLA--EENQRLREQLQLLEEQHRAA 2635
Query: 269 LPPAPAYLSSPLA 281
L + +S +A
Sbjct: 2636 LAHSEEVTASQVA 2648
Score = 41.6 bits (96), Expect = 0.001
Identities = 45/194 (23%), Positives = 89/194 (45%), Gaps = 12/194 (6%)
Query: 56 EENQELRDAIRQSNQILRER--CEELLHFQASQREEKEFLMCKFQEARKLVERLGLEKLD 113
E +EL ++N+ LR R EE+ ++ + E E + +EA + R G +
Sbjct: 1653 EAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK---QKEEAEREARRRGKAEEQ 1709
Query: 114 LKRQKEQALREVEHLKR-----CQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQ 168
RQ+E A +E+E ++ QQ++A ++ ++ + + GE Q E A + +
Sbjct: 1710 AVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQRE 1769
Query: 169 ALEGRRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRADIYKADFQAERQAR--EKLAEK 226
A +K +L+ ++ E + + S E R+ K+ + E +A +LAE+
Sbjct: 1770 AAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE 1829
Query: 227 KELLQEQLEQLQRE 240
L+ E+ +R+
Sbjct: 1830 AARLRALAEEAKRQ 1843
Score = 41.2 bits (95), Expect = 0.001
Identities = 70/254 (27%), Positives = 114/254 (44%), Gaps = 33/254 (12%)
Query: 45 QGAPETLQRCLEENQELRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLV 104
Q E +++ EE L A +++ + LR+ EE L A QR E ++ + +A +
Sbjct: 2294 QEEAEKMKQVAEEAARLSVAAQEAAR-LRQLAEEDL---AQQRALAEKMLKEKMQAVQEA 2349
Query: 105 ERLGLEKLDLKRQKE----QALREVEHLKRCQQQMAED----------------KASVKA 144
RL E L++QKE QA R E ++ QQ+AE+ + S +A
Sbjct: 2350 TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEA 2409
Query: 145 QVTSL-LGELQESQSRLE--AATKECQALEGRRKLAQLQVAYHQ---LFQEYDNHIKSSV 198
+ L + E+ +Q+R E A QA E KL + ++A + L Q + + S
Sbjct: 2410 ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSD 2469
Query: 199 VGSERKRADIYKADFQAER-QAREKLAEKK--ELLQEQLEQLQREYSKLKASCQESARIE 255
+ER R I + + + E+ Q KL + K E+ Q EQL +E L+ S
Sbjct: 2470 HDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL 2529
Query: 256 DMRKRHVEVSQAPL 269
R+R +E +A L
Sbjct: 2530 LQRERFIEQEKAKL 2543
Score = 40.8 bits (94), Expect = 0.002
Identities = 54/252 (21%), Positives = 103/252 (40%), Gaps = 34/252 (13%)
Query: 29 EESPLGKPAMLHLPS----EQGAPETLQRCLEENQELR----DAIRQSNQILRERCEEL- 79
+ES + A + L S E A QR L+ +ELR +A R+ Q ER ++
Sbjct: 1532 DESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQ 1591
Query: 80 LHFQASQREEKEFLMCK---------------------FQEARKLVERLGLEKLDLKRQK 118
+ + +QR + L K + R+ ER ++ + +R +
Sbjct: 1592 VALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAR 1651
Query: 119 EQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQALEGRRKLAQ 178
E+A RE+E Q A + ++ Q + + +Q+ E +E + RR A+
Sbjct: 1652 EEAERELERW----QLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAE 1707
Query: 179 LQVAYHQLFQEYDNHIKSSVVGSERKRADIYKADFQAERQAREKLAEKKELLQEQLEQLQ 238
Q + E + + + ++ + + R E+ ++++LL+E+L +LQ
Sbjct: 1708 EQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQ 1767
Query: 239 REYSKLKASCQE 250
RE + QE
Sbjct: 1768 REAAAATQKRQE 1779
Score = 36.2 bits (82), Expect = 0.040
Identities = 49/216 (22%), Positives = 95/216 (43%), Gaps = 24/216 (11%)
Query: 44 EQGAPETLQRCLEENQELRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKL 103
++ A Q+ E EL + +L + +++ + K+ L + R+L
Sbjct: 1767 QREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL 1826
Query: 104 VE---RLGLEKLDLKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRL 160
E RL + KRQ++ A + +Q AE + V A+ + +GE ++
Sbjct: 1827 AEEAARLRALAEEAKRQRQLAEED------AARQRAEAE-RVLAEKLAAIGEATRLKTEA 1879
Query: 161 EAATKECQALEGR-RKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRADIYKADFQAERQA 219
E A KE +A R R+LA+ + + +E + + +ADI + Q + +
Sbjct: 1880 EIALKEKEAENERLRRLAEDEAFQRRRLEEQ----------AAQHKADIEERLAQLRKAS 1929
Query: 220 REKLAEKKELLQE---QLEQLQREYSKLKASCQESA 252
+L +K L+++ Q Q++ E LKAS +++A
Sbjct: 1930 DSELERQKGLVEDTLRQRRQVEEEILALKASFEKAA 1965
Score = 35.0 bits (79), Expect = 0.089
Identities = 39/204 (19%), Positives = 83/204 (40%), Gaps = 10/204 (4%)
Query: 56 EENQELRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEA---RKLVERLGLEKL 112
E + L + + + R + E + + + E + EA R+L E+ K
Sbjct: 1857 EAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA 1916
Query: 113 DLKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQALEG 172
D++ + Q + + Q+ + ED + QV + L+ S + A E + G
Sbjct: 1917 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 1976
Query: 173 RRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRADIYKADFQAERQAREKLAEKKELLQE 232
R + + E + + + E +R +AE + ++ LA ++E ++
Sbjct: 1977 RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRR------EAEERVQKSLAAEEEAARQ 2030
Query: 233 QLEQLQREYSKLKASCQESARIED 256
+ L+ E +LKA +E+ R+ +
Sbjct: 2031 RKAALE-EVERLKAKVEEARRLRE 2053
Score = 32.0 bits (71), Expect = 0.75
Identities = 43/204 (21%), Positives = 92/204 (45%), Gaps = 16/204 (7%)
Query: 64 AIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERL-GLEKLDLKRQKEQAL 122
A+ + + E+L RE + L Q+AR+ E++ + D + +EQ
Sbjct: 1217 AVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLR 1276
Query: 123 RE---VEHLKRCQQQMAEDKASVKAQVTSLLG---ELQESQSRLE---AATKECQALEGR 173
+E +E ++R +++ E + K + ++ +L +++LE + K+ + G
Sbjct: 1277 QEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGS 1336
Query: 174 RKLAQ----LQVAYHQLFQEYDNHIKSSVVGSERKRADIYKADFQAERQAREKLAEKKEL 229
+ Q L+ Y +L +IK + + R+ + + Q + RE+LAE +
Sbjct: 1337 ESVIQEYVDLRTHYSELTTLTSQYIK-FISETLRRMEEEERLAEQQRAEERERLAEVEAA 1395
Query: 230 LQEQLEQLQREYSKLKASCQESAR 253
L++Q QL +++ KA + A+
Sbjct: 1396 LEKQ-RQLAEAHAQAKAQAEREAK 1418
>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
sapiens]
Length = 570
Score = 54.3 bits (129), Expect = 1e-07
Identities = 43/216 (19%), Positives = 100/216 (46%), Gaps = 25/216 (11%)
Query: 49 ETLQRCLEENQELRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLG 108
E +Q E+ QE + IR+ + +R + E + + R ++E + K ++ R+L E++
Sbjct: 295 EKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMH 354
Query: 109 ----LEKLDLKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAAT 164
+ + + KRQ+E+ +RE E + + +M + ++ Q +E E
Sbjct: 355 EQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQ--------EEKIREQEEMM 406
Query: 165 KECQALEGRRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRADIYKADFQAERQAREKLA 224
+E + G ++ + QE + + + K+ R+ EK+
Sbjct: 407 QEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKI----------REQEEKIR 456
Query: 225 EKKELLQEQLEQLQREYSKLKASCQESARIEDMRKR 260
E++E++QEQ E++ + K+ C++ A++++ ++
Sbjct: 457 EQEEMMQEQEEKMGEQEGKM---CEQEAKMQEQEEK 489
Score = 47.8 bits (112), Expect = 1e-05
Identities = 46/237 (19%), Positives = 112/237 (47%), Gaps = 32/237 (13%)
Query: 49 ETLQRCLEENQELRDAIRQSNQILRER------CEELLHFQASQREEKEFLMCKFQEARK 102
E ++R E E + +R+ +++ E+ EE +H Q RE++E K QE K
Sbjct: 316 EKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEE----KRQEEEK 371
Query: 103 LVERLGLEKLDLK--RQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRL 160
+ E+ ++ + K RQ+E+ + E ++ ++ M E + + Q + + +E Q +
Sbjct: 372 IREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQE 431
Query: 161 EAATKECQALEGRRKLAQLQVA----YHQLFQEYDNHI----------KSSVVGSE---R 203
E ++ + + + K + Q ++ QE + + ++ + E R
Sbjct: 432 EKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMR 491
Query: 204 KRADIYKADFQAERQAREKLAEKKELLQEQLEQLQREYSKLKASCQESARIEDMRKR 260
++ + + + R+ EK+ E++E++QEQ E++ + K+ C++ ++++ ++
Sbjct: 492 RQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKM---CEQEEKMQEQEEK 545
Score = 46.2 bits (108), Expect = 4e-05
Identities = 41/199 (20%), Positives = 94/199 (47%), Gaps = 18/199 (9%)
Query: 63 DAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGLEKLDLKRQKEQAL 122
+ IR+ + +RE+ EE++ Q + E+E M + +E + E+ + R++E+ +
Sbjct: 390 EKIREQEEKIREQ-EEMMQEQEEKMGEQEEKMWEQEEEMQ-------EQEEKMRRQEEKI 441
Query: 123 REVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQALEGRRKLAQLQVA 182
RE E R Q++ ++ + + +GE + EA +E + E R+ +
Sbjct: 442 REQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQE--EKMRRQEEKIRE 499
Query: 183 YHQLFQEYDNHIKSSVVGSERKRADIYKADFQAERQAREKLAEKKELLQEQLEQLQREYS 242
+ +E + I R++ ++ + + + EK+ E++E +QEQ E+++R+
Sbjct: 500 QEKKIREQEEKI--------REQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEE 551
Query: 243 KLKASCQESARIEDMRKRH 261
K++ + E+ + H
Sbjct: 552 KMREQEVRLRQQEEKMQEH 570
Score = 45.4 bits (106), Expect = 7e-05
Identities = 49/227 (21%), Positives = 103/227 (45%), Gaps = 15/227 (6%)
Query: 49 ETLQRCLEENQELRDAIRQSNQILRERCEELLHFQASQRE------EKEFLMCKFQ---E 99
E LQ E E++ +++ + L ER + LL Q Q E E + + K Q E
Sbjct: 216 EKLQLVESEKSEIQLNVKELKRKL-ERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVE 274
Query: 100 ARKLVERLGLEKLDLKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSR 159
+L RL ++ + ++E+ ++E E + Q++ ++ + ++ E +E R
Sbjct: 275 ENELWNRLNQQQEEKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRR 334
Query: 160 LEAATKECQALEGRRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRADIYKADFQAE--- 216
E E + E R+L + ++ ++ + + + + KR + ++ E
Sbjct: 335 QEEMMWEKE--EKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKI 392
Query: 217 RQAREKLAEKKELLQEQLEQLQREYSKLKASCQESARIEDMRKRHVE 263
R+ EK+ E++E++QEQ E++ + K+ +E E+ +R E
Sbjct: 393 REQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEE 439
Score = 44.3 bits (103), Expect = 1e-04
Identities = 50/229 (21%), Positives = 104/229 (45%), Gaps = 24/229 (10%)
Query: 40 HLPSE-QGAPETLQRCLEENQELRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQ 98
HL E Q LQ +EEN EL + + Q + R EE + +REEK Q
Sbjct: 257 HLGKELQSVSAKLQAQVEEN-ELWNRLNQQQEEKMWRQEEKIQ----EREEK------IQ 305
Query: 99 EARKLVERLGLEKLDLKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQS 158
E E++ ++ ++RQ+E + E ++R ++ M E + ++ EL+E
Sbjct: 306 EQE---EKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIR--------ELEEKMH 354
Query: 159 RLEAATKECQALEGRRKLAQLQVAYHQLFQEYDNHIKSSVVGSE-RKRADIYKADFQAER 217
E ++ + + K+ + + Q + + K + R++ ++ + +
Sbjct: 355 EQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMG 414
Query: 218 QAREKLAEKKELLQEQLEQLQREYSKLKASCQESARIEDMRKRHVEVSQ 266
+ EK+ E++E +QEQ E+++R+ K++ ++ E+ + E+ Q
Sbjct: 415 EQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQ 463
Score = 40.4 bits (93), Expect = 0.002
Identities = 35/150 (23%), Positives = 72/150 (48%), Gaps = 8/150 (5%)
Query: 45 QGAPETLQRCLEENQELRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLV 104
Q E ++R E+ +E IR+ + +RE+ EE++ Q + E+E MC+ QEA+
Sbjct: 428 QEQEEKMRRQEEKIREQEKKIREQEEKIREQ-EEMMQEQEEKMGEQEGKMCE-QEAKMQE 485
Query: 105 ERLGLEKLDLK-RQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAA 163
+ + + + K R++E+ +RE E R Q++M +++ + + E +E E
Sbjct: 486 QEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEK 545
Query: 164 TKECQALEGRRKLAQLQVAYHQLFQEYDNH 193
+ + K+ + +V Q ++ H
Sbjct: 546 MRRQE-----EKMREQEVRLRQQEEKMQEH 570
Score = 35.4 bits (80), Expect = 0.068
Identities = 41/149 (27%), Positives = 62/149 (41%), Gaps = 29/149 (19%)
Query: 131 CQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQALEGRRKLAQLQVAYHQLFQEY 190
C E KAS + Q +L EL+ + T CQ E + L Q A QL E
Sbjct: 92 CHSPEDEQKASHQHQ-EALRRELEAQVQTIRILT--CQKTELQMALYYSQHAVKQLEGEA 148
Query: 191 DNHIKS---------------SVVGSERKRADIYKADFQAERQA-----------REKLA 224
+ I S V +++K+AD Y + ER A E+L
Sbjct: 149 RDLISRLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELK 208
Query: 225 EKKELLQEQLEQLQREYSKLKASCQESAR 253
EK LQE+L+ ++ E S+++ + +E R
Sbjct: 209 EKNAKLQEKLQLVESEKSEIQLNVKELKR 237
>gi|4503593 epidermal growth factor receptor pathway substrate 15
isoform A [Homo sapiens]
Length = 896
Score = 53.9 bits (128), Expect = 2e-07
Identities = 71/287 (24%), Positives = 124/287 (43%), Gaps = 37/287 (12%)
Query: 12 EMVQPSGGPAADQDVLGEESPLGKPAMLHLPSEQGAPETLQRCLEENQELRDAIRQSNQI 71
EM+ PS + ++++G A+ L + LQR E + +++
Sbjct: 306 EMIPPSDRASLQKNIIGSSPVADFSAIKELDTLNNEIVDLQR---EKNNVEQDLKEKEDT 362
Query: 72 LRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGLEKLDLKRQKEQALREVEHLKRC 131
+++R E+ Q + E L K Q ++ V+ L E + K Q E+ L+EV K+C
Sbjct: 363 IKQRTSEVQDLQDEVQRENTNLQ-KLQAQKQQVQELLDELDEQKAQLEEQLKEVR--KKC 419
Query: 132 QQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQALEGRRKLAQLQVAYHQLFQEYD 191
++ A+ +S+KA++TS QESQ +T E + + R +L++LQ Q E +
Sbjct: 420 AEE-AQLISSLKAELTS-----QESQ----ISTYEEELAKAREELSRLQ----QETAELE 465
Query: 192 NHIKSSVVGSERKRADIYKADFQAERQARE-KLAEKKELLQEQLEQLQ------------ 238
++S E + + D Q E + + KL E K+L + QL
Sbjct: 466 ESVESGKAQLEPLQQHLQ--DSQQEISSMQMKLMEMKDL-ENHNSQLNWCSSPHSILVNG 522
Query: 239 -REYSKLKASCQESARIEDMRKRHVEVSQAPLPPAPAYLSSPLALPS 284
+Y L S E+A + + + + P+ SSP LPS
Sbjct: 523 ATDYCSLSTSSSETANLNEHVEGQSNLESEPIHQESPARSSPELLPS 569
>gi|223634475 golgi autoantigen, golgin subfamily a, 6D [Homo
sapiens]
Length = 693
Score = 53.5 bits (127), Expect = 2e-07
Identities = 53/238 (22%), Positives = 110/238 (46%), Gaps = 36/238 (15%)
Query: 47 APETLQRCLEENQELRDAI--RQSNQILRERC----------EELLHFQASQREEKEFLM 94
A T Q+ + + R+A+ R+ Q ++ER E L Q + E + +
Sbjct: 178 AVSTQQQEEDRSSSCREAVLQRRLQQTIKERALLNAHVTQVTESLKQVQLERDEYAKHIK 237
Query: 95 CKFQEARKLVERLGLEKLDLKRQKEQALREVEHLKRC----QQQMAEDKASVKAQVTSLL 150
+ ++ + ++ +E LK +K++ + ++ L+R + QMAE + VTS++
Sbjct: 238 GERARWQERMWKMSVEARTLKEEKKRDIHRIQELERSLSELKNQMAEPPSLAPPAVTSVV 297
Query: 151 GELQESQSRLEAATKECQALEGRRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRADIYK 210
+LQ+ L +E + LEG+ L + +N+ S++ E+K+ +
Sbjct: 298 EQLQDEAKHLR---QEVEGLEGK------------LQSQVENNQALSLLSKEQKQRLQEQ 342
Query: 211 ADFQAERQAR-----EKLAEKKELLQEQLEQLQREYSKLKASCQESARIEDMRKRHVE 263
+ E++A+ E+L E+ E L+EQ + LQ + +L+ Q + E+ ++ E
Sbjct: 343 EEMLREQEAQRVREQERLCEQNERLREQQKTLQEQGERLRKQEQRLRKQEERLRKEEE 400
Score = 47.4 bits (111), Expect = 2e-05
Identities = 63/256 (24%), Positives = 116/256 (45%), Gaps = 52/256 (20%)
Query: 7 KSQLCEMVQPSGGPAADQDVLGEESPLGKPAMLHLPSE-QGAPETLQRCLEENQELRDAI 65
K+Q+ E PS P A V+ + K HL E +G LQ +E NQ L
Sbjct: 279 KNQMAE--PPSLAPPAVTSVVEQLQDEAK----HLRQEVEGLEGKLQSQVENNQALSLLS 332
Query: 66 RQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGLEKLDLKRQKEQALREV 125
++ Q L+E+ EE+L Q +QR ++ +C+ ERL ++ L+ Q E+ ++
Sbjct: 333 KEQKQRLQEQ-EEMLREQEAQRVREQERLCEQN------ERLREQQKTLQEQGERLRKQE 385
Query: 126 EHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQALEGRRKLAQLQVAYHQ 185
+ L++ ++++ +++ ++ Q L + + RL + Q E R L+Q Q
Sbjct: 386 QRLRKQEERLRKEEERLQKQEK----RLWDQEERLWKKEERLQKQEERLALSQNHKLDKQ 441
Query: 186 L------FQEYDNHIKSSVVGSERKRADIYKADFQAERQAREKLAEKKELLQEQLEQLQR 239
L F++ +N KS++ Q E+Q +E LQE+L++
Sbjct: 442 LAEPQCSFEDLNNEKKSAL---------------QLEQQVKE--------LQEKLDE--- 475
Query: 240 EYSKLKASCQESARIE 255
L+A+ Q + ++E
Sbjct: 476 --EHLEAASQRNQQLE 489
Score = 33.1 bits (74), Expect = 0.34
Identities = 47/232 (20%), Positives = 93/232 (40%), Gaps = 32/232 (13%)
Query: 40 HLPSEQGAPETLQRCLEENQELRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQE 99
H P + E L LE + + + ++ + L+++ +++ H ++ + E
Sbjct: 64 HSPGDSQYQE-LAVALESSSVTINQLNENIESLKQQKKQVEHQLEEAKKTNNEIHKAQME 122
Query: 100 ARKLVERLGLEKLDLKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQE---- 155
+ + L LEK DLK + H KR + E+ + ++ L +QE
Sbjct: 123 QLETINILTLEKADLK-------TTLYHTKRAARHFEEESKDLAGRLQYSLQHIQELERA 175
Query: 156 -----SQSRLEAATKECQALEGRRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRADIYK 210
+Q + E + C+ +R+L Q + L + + S+ + +R D Y
Sbjct: 176 LCAVSTQQQEEDRSSSCREAVLQRRLQQ-TIKERALLNAHVTQVTESLKQVQLER-DEYA 233
Query: 211 ADFQAER------------QAREKLAEKKELLQEQLEQLQREYSKLKASCQE 250
+ ER +AR EKK + ++++L+R S+LK E
Sbjct: 234 KHIKGERARWQERMWKMSVEARTLKEEKKRDI-HRIQELERSLSELKNQMAE 284
>gi|51472437 PREDICTED: golgi autoantigen, golgin subfamily a, 6C
isoform 1 [Homo sapiens]
Length = 693
Score = 53.5 bits (127), Expect = 2e-07
Identities = 53/238 (22%), Positives = 110/238 (46%), Gaps = 36/238 (15%)
Query: 47 APETLQRCLEENQELRDAI--RQSNQILRERC----------EELLHFQASQREEKEFLM 94
A T Q+ + + R+A+ R+ Q ++ER E L Q + E + +
Sbjct: 178 AVSTQQQEEDRSSSCREAVLQRRLQQTIKERALLNAHVTQVTESLKQVQLERDEYAKHIK 237
Query: 95 CKFQEARKLVERLGLEKLDLKRQKEQALREVEHLKRC----QQQMAEDKASVKAQVTSLL 150
+ ++ + ++ +E LK +K++ + ++ L+R + QMAE + VTS++
Sbjct: 238 GERARWQERMWKMSVEARTLKEEKKRDIHRIQELERSLSELKNQMAEPPSLAPPAVTSVV 297
Query: 151 GELQESQSRLEAATKECQALEGRRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRADIYK 210
+LQ+ L +E + LEG+ L + +N+ S++ E+K+ +
Sbjct: 298 EQLQDEAKHLR---QEVEGLEGK------------LQSQVENNQALSLLSKEQKQRLQEQ 342
Query: 211 ADFQAERQAR-----EKLAEKKELLQEQLEQLQREYSKLKASCQESARIEDMRKRHVE 263
+ E++A+ E+L E+ E L+EQ + LQ + +L+ Q + E+ ++ E
Sbjct: 343 EEMLREQEAQRVREQERLCEQNERLREQQKTLQEQGERLRKQEQRLRKQEERLRKEEE 400
Score = 47.4 bits (111), Expect = 2e-05
Identities = 63/256 (24%), Positives = 116/256 (45%), Gaps = 52/256 (20%)
Query: 7 KSQLCEMVQPSGGPAADQDVLGEESPLGKPAMLHLPSE-QGAPETLQRCLEENQELRDAI 65
K+Q+ E PS P A V+ + K HL E +G LQ +E NQ L
Sbjct: 279 KNQMAE--PPSLAPPAVTSVVEQLQDEAK----HLRQEVEGLEGKLQSQVENNQALSLLS 332
Query: 66 RQSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGLEKLDLKRQKEQALREV 125
++ Q L+E+ EE+L Q +QR ++ +C+ ERL ++ L+ Q E+ ++
Sbjct: 333 KEQKQRLQEQ-EEMLREQEAQRVREQERLCEQN------ERLREQQKTLQEQGERLRKQE 385
Query: 126 EHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQALEGRRKLAQLQVAYHQ 185
+ L++ ++++ +++ ++ Q L + + RL + Q E R L+Q Q
Sbjct: 386 QRLRKQEERLRKEEERLQKQEK----RLWDQEERLWKKEERLQKQEERLALSQNHKLDKQ 441
Query: 186 L------FQEYDNHIKSSVVGSERKRADIYKADFQAERQAREKLAEKKELLQEQLEQLQR 239
L F++ +N KS++ Q E+Q +E LQE+L++
Sbjct: 442 LAEPQCSFEDLNNEKKSAL---------------QLEQQVKE--------LQEKLDE--- 475
Query: 240 EYSKLKASCQESARIE 255
L+A+ Q + ++E
Sbjct: 476 --EHLEAASQRNQQLE 489
Score = 33.5 bits (75), Expect = 0.26
Identities = 47/232 (20%), Positives = 93/232 (40%), Gaps = 32/232 (13%)
Query: 40 HLPSEQGAPETLQRCLEENQELRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQE 99
H P + E L LE + + + ++ + L+++ +++ H ++ + E
Sbjct: 64 HSPGDSQYQE-LAVALESSSVTINQLNENIESLKQQKKQVEHQLEEAKKTNNEIHKAQME 122
Query: 100 ARKLVERLGLEKLDLKRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSR 159
+ + L LEK DLK + H KR + E+ + ++ L +QE +
Sbjct: 123 QLETINILTLEKADLK-------TTLYHTKRAARHFEEESKDLAGRLQYSLQRIQELERA 175
Query: 160 LEAATKE---------CQALEGRRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRADIYK 210
L A + + C+ +R+L Q + L + + S+ + +R D Y
Sbjct: 176 LSAVSTQQQEEDRSSSCREAVLQRRLQQ-TIKERALLNAHVTQVTESLKQVQLER-DEYA 233
Query: 211 ADFQAER------------QAREKLAEKKELLQEQLEQLQREYSKLKASCQE 250
+ ER +AR EKK + ++++L+R S+LK E
Sbjct: 234 KHIKGERARWQERMWKMSVEARTLKEEKKRDI-HRIQELERSLSELKNQMAE 284
>gi|64085252 hypothetical protein LOC145508 [Homo sapiens]
Length = 1094
Score = 53.5 bits (127), Expect = 2e-07
Identities = 52/232 (22%), Positives = 106/232 (45%), Gaps = 30/232 (12%)
Query: 41 LPSEQGAPETLQRCLEENQELRDAIRQSNQILRERCEELLHFQASQREEKEFLMCKFQEA 100
L +G+ ETL +EE + + L+ + ++ Q++ ++E+ +
Sbjct: 295 LNQSEGSRETLLHQVEELRTQLTKAEGDRKGLQHQVSQISKQQSNYQDEQG----EDWRF 350
Query: 101 RKLVERLGLEKLDLKRQKEQA---------LREVEHLKRCQQQMAEDKASVKAQVTSLLG 151
R+ VER EK DL++Q E+E +KRC ++ ++KA + +QV +L
Sbjct: 351 RRGVER---EKQDLEKQMSDLRVQLNFSAMASELEEVKRCMERKDKEKAHLASQVENLTR 407
Query: 152 ELQESQ-------SRLEAATKECQALEGRRKLAQLQVAYHQLFQEYDNHIKSSVVGSERK 204
EL+ + RL+ E RK A LQ++ E H + + +ER
Sbjct: 408 ELENGEKQQLQMLDRLKEIQNHFDTCEAERKHADLQIS------ELTRHAEDATKQAERY 461
Query: 205 RADIYKADFQAERQAREKLAEKKELLQEQLEQLQREYSKLKASCQESARIED 256
+++ +++ E +A ++ + K QE + Q + ++ KL+ + ++ + D
Sbjct: 462 LSELQQSEALKE-EAEKRREDLKLKAQESIRQWKLKHKKLERALEKQSETVD 512
Score = 46.6 bits (109), Expect = 3e-05
Identities = 51/224 (22%), Positives = 101/224 (45%), Gaps = 28/224 (12%)
Query: 60 ELRDAIRQSNQILRERC---EELLHFQASQREEKEFLMCKFQEARKLVERLGLEKLDL-- 114
EL+ + +Q+ E+ EE+ + SQ ++K K E ++ ++ L + DL
Sbjct: 594 ELKKQSKIQSQMKVEKAHLEEEIAELKKSQAQDK----AKLLEMQESIKDLSAIRADLAN 649
Query: 115 -----KRQKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQA 169
+R K+ L+++ L + E+ A++ +T L E Q L+ T Q+
Sbjct: 650 KLAEEERAKKAVLKDLSDLTAQAKSRDEETATI---ITQLKLERDVHQRELKDLTSSLQS 706
Query: 170 LEGRRK--LAQLQVAYHQLFQEYDNHIKSSVVGS--ERKRADIYKADFQAERQAREKLAE 225
++ + + + +L + + E +NHI++ S E+ A I++ EKL
Sbjct: 707 VKTKHEQNIQELMKHFKKEKSEAENHIRTLKAESLEEKNMAKIHRGQL-------EKLKS 759
Query: 226 KKELLQEQLEQLQREYSKLKASCQESARIEDMRKRHVEVSQAPL 269
+ + L E+L Q + E KLK Q + R++H+ + + L
Sbjct: 760 QCDRLTEELTQNENENKKLKLKYQCLKDQLEEREKHISIEEEHL 803
Score = 41.6 bits (96), Expect = 0.001
Identities = 60/261 (22%), Positives = 114/261 (43%), Gaps = 29/261 (11%)
Query: 12 EMVQPSGGPAADQDVLGEESPLGKPAMLHLPSEQGAPETLQRCLEE-NQELRDAIRQSNQ 70
+M Q G + +D+ E+ LG L + +R LEE ++L +A Q +
Sbjct: 157 DMTQLHGFHQSLRDLSSEQIRLGDDFNRELSRRSRSDAETKRALEELTEKLNEA--QKQE 214
Query: 71 ILRERCE-ELLHFQASQREEKEFLMCKFQEARKLVERLGLEKLDLKRQKEQALREVEHLK 129
++ +R E L + R E+E + E R+ ++LGL L L+ E LK
Sbjct: 215 VVSDRVERRLQELEREMRTERELV-----ERRQ--DQLGLMSLQLQ----------EALK 257
Query: 130 RCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKECQALEGRRK--LAQLQVAYHQLF 187
+ + + E + ++K ++ E + + LE + + EG R+ L Q++ QL
Sbjct: 258 KQEAKADEHEGAIKNKLRQTETEKNQLEQELELSRRLLNQSEGSRETLLHQVEELRTQLT 317
Query: 188 Q-EYDNHIKSSVVGSERKRADIYKADFQAERQAREKLAEKKELLQEQLEQL--QREYSKL 244
+ E D V K+ Y+ + + + R + +K+ L++Q+ L Q +S +
Sbjct: 318 KAEGDRKGLQHQVSQISKQQSNYQDEQGEDWRFRRGVEREKQDLEKQMSDLRVQLNFSAM 377
Query: 245 KASCQESARI---EDMRKRHV 262
+ +E R +D K H+
Sbjct: 378 ASELEEVKRCMERKDKEKAHL 398
Score = 35.4 bits (80), Expect = 0.068
Identities = 55/236 (23%), Positives = 102/236 (43%), Gaps = 37/236 (15%)
Query: 51 LQRCLEENQELRDAIR-QSNQILRERCEELLHFQASQREEKEFLMCKFQEARKLVERLGL 109
L+R LE+ E D + ++NQIL+E+ E L + A + +E L
Sbjct: 500 LERALEKQSETVDELTGKNNQILKEKDE---------------LKTQLYAALQQIENLRK 544
Query: 110 EKLDL--KR--QKEQALREVEHLKRCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATK 165
E D+ KR Q+E+ + E L+ + A+ + VK + ++ RLE+ K
Sbjct: 545 ELNDVLTKRALQEEELHSKEEKLRDIKSHQADLELEVKNSLDTI--------HRLESELK 596
Query: 166 ECQALEGRRKLAQLQVAYHQLFQEYDNHIKSSVVGSERKRADIYKA--DFQAER-QAREK 222
+ ++ + K+ + + +E +K S + K ++ ++ D A R K
Sbjct: 597 KQSKIQSQMKVEKAHL------EEEIAELKKSQAQDKAKLLEMQESIKDLSAIRADLANK 650
Query: 223 LAEKKELLQEQLEQLQREYSKLKASCQESARIEDMRKRHVEVSQAPLPPAPAYLSS 278
LAE++ + L+ L ++ K+ +E+A I K +V Q L + L S
Sbjct: 651 LAEEERAKKAVLKDLSDLTAQAKSRDEETATIITQLKLERDVHQRELKDLTSSLQS 706
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.129 0.364
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,278,605
Number of Sequences: 37866
Number of extensions: 683876
Number of successful extensions: 11288
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 277
Number of HSP's successfully gapped in prelim test: 912
Number of HSP's that attempted gapping in prelim test: 6438
Number of HSP's gapped (non-prelim): 3738
length of query: 320
length of database: 18,247,518
effective HSP length: 102
effective length of query: 218
effective length of database: 14,385,186
effective search space: 3135970548
effective search space used: 3135970548
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.