Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 222537743
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|222537743 protein tyrosine phosphatase, receptor type, Q
[Homo sapiens]
(2299 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|222537743 protein tyrosine phosphatase, receptor type, Q [Hom... 4633 0.0
gi|157952215 protein tyrosine phosphatase, receptor type, B isof... 296 2e-79
gi|157952213 protein tyrosine phosphatase, receptor type, B isof... 296 2e-79
gi|13677220 receptor-type protein tyrosine phosphatase O isoform... 286 2e-76
gi|13677216 receptor-type protein tyrosine phosphatase O isoform... 286 2e-76
gi|4506323 receptor-type protein tyrosine phosphatase O isoform ... 286 2e-76
gi|13677222 receptor-type protein tyrosine phosphatase O isoform... 283 2e-75
gi|13677218 receptor-type protein tyrosine phosphatase O isoform... 283 2e-75
gi|13677214 receptor-type protein tyrosine phosphatase O isoform... 283 2e-75
gi|104487611 protein tyrosine phosphatase, receptor type, sigma ... 273 2e-72
gi|104487295 protein tyrosine phosphatase, receptor type, sigma ... 273 2e-72
gi|219842266 usherin isoform B [Homo sapiens] 269 3e-71
gi|148539860 protein tyrosine phosphatase, receptor type, T isof... 259 3e-68
gi|148728162 protein tyrosine phosphatase, receptor type, J isof... 256 1e-67
gi|109633041 protein tyrosine phosphatase, receptor type, F isof... 254 5e-67
gi|109633039 protein tyrosine phosphatase, receptor type, F isof... 254 5e-67
gi|4506309 protein tyrosine phosphatase, receptor type, D isofor... 248 4e-65
gi|18860890 protein tyrosine phosphatase, receptor type, D isofo... 248 4e-65
gi|18860892 protein tyrosine phosphatase, receptor type, D isofo... 248 4e-65
gi|18860894 protein tyrosine phosphatase, receptor type, D isofo... 248 4e-65
gi|104487002 protein tyrosine phosphatase, receptor type, D isof... 246 1e-64
gi|119220552 sidekick 1 [Homo sapiens] 245 3e-64
gi|104487297 protein tyrosine phosphatase, receptor type, sigma ... 241 5e-63
gi|104487006 protein tyrosine phosphatase, receptor type, sigma ... 241 6e-63
gi|157419150 protein tyrosine phosphatase, receptor type, M isof... 240 1e-62
gi|241896926 protein tyrosine phosphatase, receptor type, H isof... 238 5e-62
gi|241896924 protein tyrosine phosphatase, receptor type, H isof... 238 5e-62
gi|18860902 protein tyrosine phosphatase, receptor type, K isofo... 236 1e-61
gi|208431815 protein tyrosine phosphatase, receptor type, K isof... 230 1e-59
gi|148539858 protein tyrosine phosphatase, receptor type, T isof... 223 2e-57
>gi|222537743 protein tyrosine phosphatase, receptor type, Q [Homo
sapiens]
Length = 2299
Score = 4633 bits (12016), Expect = 0.0
Identities = 2299/2299 (100%), Positives = 2299/2299 (100%)
Query: 1 MDFLIIFLLLFIGTSETQVDVSNVVPGTRYDITISSISTTYTSPVTRIVTTNVTKPGPPV 60
MDFLIIFLLLFIGTSETQVDVSNVVPGTRYDITISSISTTYTSPVTRIVTTNVTKPGPPV
Sbjct: 1 MDFLIIFLLLFIGTSETQVDVSNVVPGTRYDITISSISTTYTSPVTRIVTTNVTKPGPPV 60
Query: 61 FLAGERVGSAGILLSWNTPPNPNGRIISYIVKYKEVCPWMQTVYTQVRSKPDSLEVLLTN 120
FLAGERVGSAGILLSWNTPPNPNGRIISYIVKYKEVCPWMQTVYTQVRSKPDSLEVLLTN
Sbjct: 61 FLAGERVGSAGILLSWNTPPNPNGRIISYIVKYKEVCPWMQTVYTQVRSKPDSLEVLLTN 120
Query: 121 LNPGTTYEIKVAAENSAGIGVFSDPFLFQTAESAPGKVVNLTVEAYNASAVKLIWYLPRQ 180
LNPGTTYEIKVAAENSAGIGVFSDPFLFQTAESAPGKVVNLTVEAYNASAVKLIWYLPRQ
Sbjct: 121 LNPGTTYEIKVAAENSAGIGVFSDPFLFQTAESAPGKVVNLTVEAYNASAVKLIWYLPRQ 180
Query: 181 PNGKITSFKISVKHARSGIVVKDVSIRVEDILTGKLPECNENSESFLWSTASPSPTLGRV 240
PNGKITSFKISVKHARSGIVVKDVSIRVEDILTGKLPECNENSESFLWSTASPSPTLGRV
Sbjct: 181 PNGKITSFKISVKHARSGIVVKDVSIRVEDILTGKLPECNENSESFLWSTASPSPTLGRV 240
Query: 241 TPPSRTTHSSSTLTQNEISSVWKEPISFVVTHLRPYTTYLFEVSAATTEAGYIDSTIVRT 300
TPPSRTTHSSSTLTQNEISSVWKEPISFVVTHLRPYTTYLFEVSAATTEAGYIDSTIVRT
Sbjct: 241 TPPSRTTHSSSTLTQNEISSVWKEPISFVVTHLRPYTTYLFEVSAATTEAGYIDSTIVRT 300
Query: 301 PESVPEGPPQNCVTGNITGKSFSILWDPPTIVTGKFSYRVELYGPSGRILDNSTKDLKFA 360
PESVPEGPPQNCVTGNITGKSFSILWDPPTIVTGKFSYRVELYGPSGRILDNSTKDLKFA
Sbjct: 301 PESVPEGPPQNCVTGNITGKSFSILWDPPTIVTGKFSYRVELYGPSGRILDNSTKDLKFA 360
Query: 361 FTNLTPFTMYDVYIAAETSAGTGPKSNISVFTPPDVPGAVFDLQLAEVESTQVRITWKKP 420
FTNLTPFTMYDVYIAAETSAGTGPKSNISVFTPPDVPGAVFDLQLAEVESTQVRITWKKP
Sbjct: 361 FTNLTPFTMYDVYIAAETSAGTGPKSNISVFTPPDVPGAVFDLQLAEVESTQVRITWKKP 420
Query: 421 RQPNGIINQYRVKVLVPETGIILENTLLTGNNEYINDPMAPEIVNIVEPMVGLYEGSAEM 480
RQPNGIINQYRVKVLVPETGIILENTLLTGNNEYINDPMAPEIVNIVEPMVGLYEGSAEM
Sbjct: 421 RQPNGIINQYRVKVLVPETGIILENTLLTGNNEYINDPMAPEIVNIVEPMVGLYEGSAEM 480
Query: 481 SSDLHSLATFIYNSHPDKNFPARNRAEDQTSPVVTTRNQYITDIAAEQLSYVIRRLVPFT 540
SSDLHSLATFIYNSHPDKNFPARNRAEDQTSPVVTTRNQYITDIAAEQLSYVIRRLVPFT
Sbjct: 481 SSDLHSLATFIYNSHPDKNFPARNRAEDQTSPVVTTRNQYITDIAAEQLSYVIRRLVPFT 540
Query: 541 EHMISVSAFTIMGEGPPTVLSVRTRQQVPSSIKIINYKNISSSSILLYWDPPEYPNGKIT 600
EHMISVSAFTIMGEGPPTVLSVRTRQQVPSSIKIINYKNISSSSILLYWDPPEYPNGKIT
Sbjct: 541 EHMISVSAFTIMGEGPPTVLSVRTRQQVPSSIKIINYKNISSSSILLYWDPPEYPNGKIT 600
Query: 601 HYTIYAMELDTNRAFQITTIDNSFLITGLKKYTKYKMRVAASTHVGESSLSEENDIFVRT 660
HYTIYAMELDTNRAFQITTIDNSFLITGLKKYTKYKMRVAASTHVGESSLSEENDIFVRT
Sbjct: 601 HYTIYAMELDTNRAFQITTIDNSFLITGLKKYTKYKMRVAASTHVGESSLSEENDIFVRT 660
Query: 661 SEDEPESSPQDVEVIDVTADEIRLKWSPPEKPNGIIIAYEVLYKNIDTLYMKNTSTTDII 720
SEDEPESSPQDVEVIDVTADEIRLKWSPPEKPNGIIIAYEVLYKNIDTLYMKNTSTTDII
Sbjct: 661 SEDEPESSPQDVEVIDVTADEIRLKWSPPEKPNGIIIAYEVLYKNIDTLYMKNTSTTDII 720
Query: 721 LRNLRPHTLYNISVRSYTRFGHGNQVSSLLSVRTSETVPDSAPENITYKNISSGEIELSF 780
LRNLRPHTLYNISVRSYTRFGHGNQVSSLLSVRTSETVPDSAPENITYKNISSGEIELSF
Sbjct: 721 LRNLRPHTLYNISVRSYTRFGHGNQVSSLLSVRTSETVPDSAPENITYKNISSGEIELSF 780
Query: 781 LPPSSPNGIIQKYTIYLKRSNGNEERTINTTSLTQNIKVLKKYTQYIIEVSASTLKGEGV 840
LPPSSPNGIIQKYTIYLKRSNGNEERTINTTSLTQNIKVLKKYTQYIIEVSASTLKGEGV
Sbjct: 781 LPPSSPNGIIQKYTIYLKRSNGNEERTINTTSLTQNIKVLKKYTQYIIEVSASTLKGEGV 840
Query: 841 RSAPISILTEEDAPDSPPQDFSVKQLSGVTVKLSWQPPLEPNGIILYYTVYVWNRSSLKT 900
RSAPISILTEEDAPDSPPQDFSVKQLSGVTVKLSWQPPLEPNGIILYYTVYVWNRSSLKT
Sbjct: 841 RSAPISILTEEDAPDSPPQDFSVKQLSGVTVKLSWQPPLEPNGIILYYTVYVWNRSSLKT 900
Query: 901 INVTETSLELSDLDYNVEYSAYVTASTRFGDGKTRSNIISFQTPEGAPSDPPKDVYYANL 960
INVTETSLELSDLDYNVEYSAYVTASTRFGDGKTRSNIISFQTPEGAPSDPPKDVYYANL
Sbjct: 901 INVTETSLELSDLDYNVEYSAYVTASTRFGDGKTRSNIISFQTPEGAPSDPPKDVYYANL 960
Query: 961 SSSSIILFWTPPSKPNGIIQYYSVYYRNTSGTFMQNFTLHEVTNDFDNMTVSTIIDKLTI 1020
SSSSIILFWTPPSKPNGIIQYYSVYYRNTSGTFMQNFTLHEVTNDFDNMTVSTIIDKLTI
Sbjct: 961 SSSSIILFWTPPSKPNGIIQYYSVYYRNTSGTFMQNFTLHEVTNDFDNMTVSTIIDKLTI 1020
Query: 1021 FSYYTFWLTASTSVGNGNKSSDIIEVYTDQDIPEGFVGNLTYESISSTAINVSWVPPAQP 1080
FSYYTFWLTASTSVGNGNKSSDIIEVYTDQDIPEGFVGNLTYESISSTAINVSWVPPAQP
Sbjct: 1021 FSYYTFWLTASTSVGNGNKSSDIIEVYTDQDIPEGFVGNLTYESISSTAINVSWVPPAQP 1080
Query: 1081 NGLVFYYVSLILQQTPRHVRPPLVTYERSIYFDNLEKYTDYILKITPSTEKGFSDTYTAQ 1140
NGLVFYYVSLILQQTPRHVRPPLVTYERSIYFDNLEKYTDYILKITPSTEKGFSDTYTAQ
Sbjct: 1081 NGLVFYYVSLILQQTPRHVRPPLVTYERSIYFDNLEKYTDYILKITPSTEKGFSDTYTAQ 1140
Query: 1141 LYIKTEEDVPETSPIINTFKNLSSTSVLLSWDPPVKPNGAIISYDLTLQGPNENYSFITS 1200
LYIKTEEDVPETSPIINTFKNLSSTSVLLSWDPPVKPNGAIISYDLTLQGPNENYSFITS
Sbjct: 1141 LYIKTEEDVPETSPIINTFKNLSSTSVLLSWDPPVKPNGAIISYDLTLQGPNENYSFITS 1200
Query: 1201 DNYIILEELSPFTLYSFFAAARTRKGLGPSSILFFYTDESVPLAPPQNLTLINCTSDFVW 1260
DNYIILEELSPFTLYSFFAAARTRKGLGPSSILFFYTDESVPLAPPQNLTLINCTSDFVW
Sbjct: 1201 DNYIILEELSPFTLYSFFAAARTRKGLGPSSILFFYTDESVPLAPPQNLTLINCTSDFVW 1260
Query: 1261 LKWSPSPLPGGIVKVYSFKIHEHETDTIYYKNISGFKTEAKLVGLEPVSTYSIRVSAFTK 1320
LKWSPSPLPGGIVKVYSFKIHEHETDTIYYKNISGFKTEAKLVGLEPVSTYSIRVSAFTK
Sbjct: 1261 LKWSPSPLPGGIVKVYSFKIHEHETDTIYYKNISGFKTEAKLVGLEPVSTYSIRVSAFTK 1320
Query: 1321 VGNGNQFSNVVKFTTQESVPDVVQNMQCMATSWQSVLVKWDPPKKANGIITQYMVTVERN 1380
VGNGNQFSNVVKFTTQESVPDVVQNMQCMATSWQSVLVKWDPPKKANGIITQYMVTVERN
Sbjct: 1321 VGNGNQFSNVVKFTTQESVPDVVQNMQCMATSWQSVLVKWDPPKKANGIITQYMVTVERN 1380
Query: 1381 STKVSPQDHMYTFIKLLANTSYVFKVRASTSAGEGDESTCHVSTLPETVPSVPTNIAFSD 1440
STKVSPQDHMYTFIKLLANTSYVFKVRASTSAGEGDESTCHVSTLPETVPSVPTNIAFSD
Sbjct: 1381 STKVSPQDHMYTFIKLLANTSYVFKVRASTSAGEGDESTCHVSTLPETVPSVPTNIAFSD 1440
Query: 1441 VQSTSATLTWIRPDTILGYFQNYKITTQLRAQKCKEWESEECVEYQKIQYLYEAHLTEET 1500
VQSTSATLTWIRPDTILGYFQNYKITTQLRAQKCKEWESEECVEYQKIQYLYEAHLTEET
Sbjct: 1441 VQSTSATLTWIRPDTILGYFQNYKITTQLRAQKCKEWESEECVEYQKIQYLYEAHLTEET 1500
Query: 1501 VYGLKKFRWYRFQVAASTNAGYGNASNWISTKTLPGPPDGPPENVHVVATSPFSISISWS 1560
VYGLKKFRWYRFQVAASTNAGYGNASNWISTKTLPGPPDGPPENVHVVATSPFSISISWS
Sbjct: 1501 VYGLKKFRWYRFQVAASTNAGYGNASNWISTKTLPGPPDGPPENVHVVATSPFSISISWS 1560
Query: 1561 EPAVITGPTCYLIDVKSVDNDEFNISFIKSNEENKTIEIKDLEIFTRYSVVITAFTGNIS 1620
EPAVITGPTCYLIDVKSVDNDEFNISFIKSNEENKTIEIKDLEIFTRYSVVITAFTGNIS
Sbjct: 1561 EPAVITGPTCYLIDVKSVDNDEFNISFIKSNEENKTIEIKDLEIFTRYSVVITAFTGNIS 1620
Query: 1621 AAYVEGKSSAEMIVTTLESAPKDPPNNMTFQKIPDEVTKFQLTFLPPSQPNGNIQVYQAL 1680
AAYVEGKSSAEMIVTTLESAPKDPPNNMTFQKIPDEVTKFQLTFLPPSQPNGNIQVYQAL
Sbjct: 1621 AAYVEGKSSAEMIVTTLESAPKDPPNNMTFQKIPDEVTKFQLTFLPPSQPNGNIQVYQAL 1680
Query: 1681 VYREDDPTAVQIHNLSIIQKTNTFVIAMLEGLKGGHTYNISVYAVNSAGAGPKVPMRITM 1740
VYREDDPTAVQIHNLSIIQKTNTFVIAMLEGLKGGHTYNISVYAVNSAGAGPKVPMRITM
Sbjct: 1681 VYREDDPTAVQIHNLSIIQKTNTFVIAMLEGLKGGHTYNISVYAVNSAGAGPKVPMRITM 1740
Query: 1741 DIKAPARPKTKPTPIYDATGKLLVTSTTITIRMPICYYSDDHGPIKNVQVLVTETGAQHD 1800
DIKAPARPKTKPTPIYDATGKLLVTSTTITIRMPICYYSDDHGPIKNVQVLVTETGAQHD
Sbjct: 1741 DIKAPARPKTKPTPIYDATGKLLVTSTTITIRMPICYYSDDHGPIKNVQVLVTETGAQHD 1800
Query: 1801 GNVTKWYDAYFNKARPYFTNEGFPNPPCTEGKTKFSGNEEIYIIGADNACMIPGNEDKIC 1860
GNVTKWYDAYFNKARPYFTNEGFPNPPCTEGKTKFSGNEEIYIIGADNACMIPGNEDKIC
Sbjct: 1801 GNVTKWYDAYFNKARPYFTNEGFPNPPCTEGKTKFSGNEEIYIIGADNACMIPGNEDKIC 1860
Query: 1861 NGPLKPKKQYLFKFRATNIMGQFTDSDYSDPVKTLGEGLSERTVEIILSVTLCILSIILL 1920
NGPLKPKKQYLFKFRATNIMGQFTDSDYSDPVKTLGEGLSERTVEIILSVTLCILSIILL
Sbjct: 1861 NGPLKPKKQYLFKFRATNIMGQFTDSDYSDPVKTLGEGLSERTVEIILSVTLCILSIILL 1920
Query: 1921 GTAIFAFARIRQKQKEGGTYSPQDAEIIDTKLKLDQLITVADLELKDERLTRLLSYRKSI 1980
GTAIFAFARIRQKQKEGGTYSPQDAEIIDTKLKLDQLITVADLELKDERLTRLLSYRKSI
Sbjct: 1921 GTAIFAFARIRQKQKEGGTYSPQDAEIIDTKLKLDQLITVADLELKDERLTRLLSYRKSI 1980
Query: 1981 KPISKKSFLQHVEELCTNNNLKFQEEFSELPKFLQDLSSTDADLPWNRAKNRFPNIKPYN 2040
KPISKKSFLQHVEELCTNNNLKFQEEFSELPKFLQDLSSTDADLPWNRAKNRFPNIKPYN
Sbjct: 1981 KPISKKSFLQHVEELCTNNNLKFQEEFSELPKFLQDLSSTDADLPWNRAKNRFPNIKPYN 2040
Query: 2041 NNRVKLIADASVPGSDYINASYISGYLCPNEFIATQGPLPGTVGDFWRMVWETRAKTLVM 2100
NNRVKLIADASVPGSDYINASYISGYLCPNEFIATQGPLPGTVGDFWRMVWETRAKTLVM
Sbjct: 2041 NNRVKLIADASVPGSDYINASYISGYLCPNEFIATQGPLPGTVGDFWRMVWETRAKTLVM 2100
Query: 2101 LTQCFEKGRIRCHQYWPEDNKPVTVFGDIVITKLMEDVQIDWTIRDLKIERHGDCMTVRQ 2160
LTQCFEKGRIRCHQYWPEDNKPVTVFGDIVITKLMEDVQIDWTIRDLKIERHGDCMTVRQ
Sbjct: 2101 LTQCFEKGRIRCHQYWPEDNKPVTVFGDIVITKLMEDVQIDWTIRDLKIERHGDCMTVRQ 2160
Query: 2161 CNFTAWPEHGVPENSAPLIHFVKLVRASRAHDTTPMIVHCSAGVGRTGVFIALDHLTQHI 2220
CNFTAWPEHGVPENSAPLIHFVKLVRASRAHDTTPMIVHCSAGVGRTGVFIALDHLTQHI
Sbjct: 2161 CNFTAWPEHGVPENSAPLIHFVKLVRASRAHDTTPMIVHCSAGVGRTGVFIALDHLTQHI 2220
Query: 2221 NDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLLSNKGSNQPICFVNYSALQKM 2280
NDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLLSNKGSNQPICFVNYSALQKM
Sbjct: 2221 NDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLLSNKGSNQPICFVNYSALQKM 2280
Query: 2281 DSLDAMEGDVELEWEETTM 2299
DSLDAMEGDVELEWEETTM
Sbjct: 2281 DSLDAMEGDVELEWEETTM 2299
>gi|157952215 protein tyrosine phosphatase, receptor type, B isoform a
[Homo sapiens]
Length = 2215
Score = 296 bits (758), Expect = 2e-79
Identities = 388/1552 (25%), Positives = 656/1552 (42%), Gaps = 191/1552 (12%)
Query: 761 SAPENITYKNISS-GEIELSFLPPSSPNGIIQKYTIYLKRSNGN-EERTINTTSLTQNIK 818
+ P +T ++++ G F + G ++ Y + L N + +I++ + +
Sbjct: 770 TVPAQVTDLHVANQGMTSSLFTNWTQAQGDVEFYQVLLIHENVVIKNESISSETSRYSFH 829
Query: 819 VLKKYTQYIIEVSASTLKGEGVRSAPISILTEEDAPDSPPQDFSVKQLSGVTVK------ 872
LK + Y + V+ T+ G G+ S + ++ P S +SGVTV
Sbjct: 830 SLKSGSLYSVVVT--TVSG-GISSRQV-VVEGRTVPSS---------VSGVTVNNSGRND 876
Query: 873 ---LSWQPPLEPNGIILYYTVYVWNRSSLKTINVTETSLELSDLDYNVEYSAYVTASTRF 929
+SW L P + Y + ++++ + ++ E S VT +TR
Sbjct: 877 YLSVSWL--LAPGDVDNYEVTLSHDGKVVQSLVIAKSVRECSFSSLTPGRLYTVTITTRS 934
Query: 930 GDGKTRSNIISFQTPEGAPSDPPKDVYYANLSSSSII-LFWTPPSKPNGIIQYYSVYYRN 988
G + S F P D + V +N + S + + W + G +Y V +N
Sbjct: 935 GKYENHS----FSQERTVP-DKVQGVSVSNSARSDYLRVSWVHAT---GDFDHYEVTIKN 986
Query: 989 TSGTFMQNFTLHEVTNDFDNMTVSTIIDKLTIFSYYTFWLTASTSVGNGNKSSDIIEVYT 1048
+ F+Q ++ + N+ + +L Y+ +T + N+ +
Sbjct: 987 KNN-FIQTKSIPKSENE-------CVFVQLVPGRLYSVTVTTKSGQYEANEQGN------ 1032
Query: 1049 DQDIPEGFVGNLTYESISSTAINVSWVPPAQPNGLVFYYVSLILQQTPRHVRPP--LVTY 1106
+ IPE V +LT + S+ ++V+W + NG V Y +L + V PP LV
Sbjct: 1033 GRTIPEP-VKDLTLRNRSTEDLHVTW---SGANGDVDQYEIQLLFNDMK-VFPPFHLVNT 1087
Query: 1107 ERSIYFDNLEKYTDY-ILKITPS---TEKGFSDTYTAQLYIKTEEDVPETSPIINTFKNL 1162
F +L Y IL +T S + F + +T VP I+ N
Sbjct: 1088 ATEYRFTSLTPGRQYKILVLTISGDVQQSAFIEGFT----------VPSAVKNIHISPNG 1137
Query: 1163 SSTSVLLSWDPPVKPNGAIISYDLTLQGPNENYSFITSDNYII---LEELSPFTLYSFFA 1219
++ S+ ++W P G + SY ++ ++ T ++ L Y
Sbjct: 1138 ATDSLTVNWTPG---GGDVDSYTVSAFRHSQKVDSQTIPKHVFEHTFHRLEAGEQYQIMI 1194
Query: 1220 AARTRKGLGPSSILFFYTDESVPLAPPQNLTLINCTSDF-VWLKWSPSPLPGGIVKVYSF 1278
A+ + +++ +VP A Q + N S + + + W + G+ + Y
Sbjct: 1195 ASVSGSLKNQINVV----GRTVP-ASVQGVIADNAYSSYSLIVSWQKA---AGVAERYDI 1246
Query: 1279 KIHEHETDTIYYKNISGFKTEAKLVGLEPVSTYSIRVSAFTKVGNGNQFSNVVKFTTQES 1338
+ + + + K L P Y I++ + G FS + T +
Sbjct: 1247 LLLTENGILLRNTSEPATTKQHKFEDLTPGKKYKIQILTVS----GGLFSKEAQ-TEGRT 1301
Query: 1339 VPDVVQNMQCMATSWQSVLVKWDPPKKANGIITQYMVTVERN---STKVSPQDHMYTFIK 1395
VP V +++ S + + +W + ++ + N +V P ++F
Sbjct: 1302 VPAAVTDLRITENSTRHLSFRWTASEGELSWYNIFLYNPDGNLQERAQVDPLVQSFSFQN 1361
Query: 1396 LLANTSYVFKVRASTSAGE-GDESTCHVSTLPETVPSVPTNIAFSDVQSTSATLTWIRPD 1454
LL Y K+ T +GE +ES T+P +V +++ S+ +T + W
Sbjct: 1362 LLQGRMY--KMVIVTHSGELSNESFIFGRTVPASV----SHLRGSNRNTTDSL--WFNWS 1413
Query: 1455 TILGYFQNYK-ITTQLRAQKCKEWESEECVEYQKIQYLYEAHLTEETVYGLKKFRWYRFQ 1513
G F Y+ I K + W+ ++ LTE GL R Y
Sbjct: 1414 PASGDFDFYELILYNPNGTKKENWKDKD--------------LTEWRFQGLVPGRKYVLW 1459
Query: 1514 VAASTNAGYGNASNWISTKTLPGPPDGPPENVHVVATSPFSISISWSEPAVITGPTCYLI 1573
V + G+ SN ++ ++ P PP + + S++I+W P T +
Sbjct: 1460 VVTHS----GDLSNKVTAESRTAP--SPPSLMSFADIANTSLAITWKGPPDWTDYNDF-- 1511
Query: 1574 DVKSVDNDEFNISFIKSNEENKTIEIKDLEIFTRYSVVITAFTGNISAAYVEGKSSAEMI 1633
+++ + D + +N +++ + L Y + +G+ K+ ++ I
Sbjct: 1512 ELQWLPRDALTVFNPYNNRKSEGRIVYGLRPGRSYQFNVKTVSGD------SWKTYSKPI 1565
Query: 1634 VTTLESAPKDPPNNMTFQKIPDEVTKFQLTFLPPSQPNGNIQVYQALVYREDDPTAVQIH 1693
++ + P D N+ + P T +++PP + + Y ++ R+ D V+
Sbjct: 1566 FGSVRTKP-DKIQNLHCR--PQNSTAIACSWIPP---DSDFDGY-SIECRKMDTQEVEFS 1618
Query: 1694 NLSIIQKTNTFVIAMLEGLKGGHTYNISVYAVNSAGAGPKVPMRITMDIKAPARPKTKPT 1753
++K + + M+ L Y +S+ V SAG +V T I RP P
Sbjct: 1619 RK--LEKEKSLLNIMM--LVPHKRYLVSI-KVQSAGMTSEVVEDST--ITMIDRPPPPPP 1671
Query: 1754 PIYDATGKLLVTSTTITIRMPICYYSDDHGPIKNVQVLVTETGAQHDGNVTKW-----YD 1808
I +L++ ++I + ++SD +G +K V+V E + + Y
Sbjct: 1672 HIRVNEKDVLISKSSINFTVNCSWFSDTNGAVKYFTVVVREADGSDELKPEQQHPLPSYL 1731
Query: 1809 AYFNKA--RPYFTNEGFPNPPCTEGKTKFSGNEEIYIIGADNACM---IPGNEDKICNGP 1863
Y + A R Y TN + C E S + I + GA+ + + K C+GP
Sbjct: 1732 EYRHNASIRVYQTN--YFASKCAENPNSNSKSFNIKL-GAEMESLGGKCDPTQQKFCDGP 1788
Query: 1864 LKPKKQYLFKFRA-----TNIMGQFTDSDYSD-----PVKTLGEGLSERTVEIILSVTLC 1913
LKP Y RA + +FT YSD P+ T E L + S L
Sbjct: 1789 LKPHTAYRISIRAFTQLFDEDLKEFTKPLYSDTFFSLPITTESEPLFGAIEGV--SAGLF 1846
Query: 1914 ILSIILLGTAIFAFARIRQKQKEGGTYSPQDAEIIDTKLKLDQLITVADLELKDERLTRL 1973
++ +++ A+ A RQK G ++ ++ D+ ++V L L +
Sbjct: 1847 LIGMLV---AVVALLICRQKVSHG-----RERPSARLSIRRDRPLSV-HLNLGQK----- 1892
Query: 1974 LSYRKSIKPISKKSFLQHVEELCTNNNLKFQEEFSELPKFLQDLSSTDADLPWNRAKNRF 2033
RK+ PI F H +L ++N +E+ EL ++ S A LP NR KNR+
Sbjct: 1893 -GNRKTSCPIKINQFEGHFMKLQADSNYLLSKEYEELKDVGRNQSCDIALLPENRGKNRY 1951
Query: 2034 PNIKPYNNNRVKLIADASVPGSDYINASYISGYLCPNEFIATQGPLPGTVGDFWRMVWET 2093
NI PY+ RVKL P SDYINASYI G E+I TQGPLPGT DFW+MVWE
Sbjct: 1952 NNILPYDATRVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPGTKDDFWKMVWEQ 2011
Query: 2094 RAKTLVMLTQCFEKGRIRCHQYWPEDNKPVTVFGDIVITKLMEDVQIDWTIRDLKI---E 2150
+VM+TQC EKGR++C YWP D + +GD+++ L E V +WTIR+ KI E
Sbjct: 2012 NVHNIVMVTQCVEKGRVKCDHYWPADQDSL-YYGDLILQMLSESVLPEWTIREFKICGEE 2070
Query: 2151 RHGDCMTVRQCNFTAWPEHGVPENSAPLIHFVKLVR--ASRAHDTTPMIVHCSAGVGRTG 2208
+ +R ++T WP+HGVPE + LI FV+ VR +R+ P +VHCSAGVGRTG
Sbjct: 2071 QLDAHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPGAGPTVVHCSAGVGRTG 2130
Query: 2209 VFIALDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLL 2260
FIALD + Q ++ D VDIYG V +LR R+ MVQ QY++LHQC+ D+L
Sbjct: 2131 TFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRDVL 2182
Score = 53.5 bits (127), Expect = 2e-06
Identities = 197/1029 (19%), Positives = 377/1029 (36%), Gaps = 158/1029 (15%)
Query: 17 TQVDVSNVVPGTRYDITISSISTTYTSPVTRIVTTNVTKPGPPVFLAGERVGSAGILLSW 76
T+ +VPG Y +T+S +S ++ + T K
Sbjct: 559 TETHFKELVPGRLYQVTVSCVSGELSAQKMAVGRTFPDKVA------------------- 599
Query: 77 NTPPNPNGRIISYIVKYKEVC-PWMQ---------TVYTQVRSKPDSLEVLL--TNLNPG 124
N N NGR+ S +V + W Q V + + + ++ T L PG
Sbjct: 600 NLEANNNGRMRSLVVSWSPPAGDWEQYRILLFNDSVVLLNITVGKEETQYVMDDTGLVPG 659
Query: 125 TTYEIKVAAENSAGIGVFSDPFLFQTAESAPGKVVNLTVEAYNASAVKLIWYLPRQPNGK 184
YE++V E+ G + Q + P V+ L V+ N +++ ++W + P +
Sbjct: 660 RQYEVEVIVES----GNLKNSERCQ-GRTVPLAVLQLRVKHANETSLSIMW---QTPVAE 711
Query: 185 ITSFKISVKHARSGIVVKDVS-----IRVEDILTGKLPECN--------ENSESFLWSTA 231
+ IS+ ++ K +S D++ G+ +NS S T
Sbjct: 712 WEKYIISLADRDLLLIHKSLSKDAKEFTFTDLVPGRKYMATVTSISGDLKNSSSVKGRTV 771
Query: 232 SPSPTLGRVTPPSRTTHSSSTLTQ-------------NEISSVWKEPISFVVTHLRPYTT 278
T V T+ + TQ +E + E IS + ++
Sbjct: 772 PAQVTDLHVANQGMTSSLFTNWTQAQGDVEFYQVLLIHENVVIKNESISSETSRYSFHSL 831
Query: 279 Y---LFEVSAATTEAGYIDSTIVRTPESVPEGPPQNCVTGNITGKS--FSILWDPPTIVT 333
L+ V T G +V +VP + VT N +G++ S+ W +
Sbjct: 832 KSGSLYSVVVTTVSGGISSRQVVVEGRTVPSSV--SGVTVNNSGRNDYLSVSW---LLAP 886
Query: 334 GKF-SYRVELYGPSGRILDN---STKDLKFAFTNLTPFTMYDVYIAAETSAGTGPKSNIS 389
G +Y V L G+++ + + + +F++LTP +Y V I + G N S
Sbjct: 887 GDVDNYEVTL-SHDGKVVQSLVIAKSVRECSFSSLTPGRLYTVTITTRS----GKYENHS 941
Query: 390 VFTPPDVPGAVFDLQLAE-VESTQVRITWKKPRQPNGIINQYRVKVLVPETGIILENTLL 448
VP V + ++ S +R++W G + Y V + + I ++
Sbjct: 942 FSQERTVPDKVQGVSVSNSARSDYLRVSWV---HATGDFDHYEVTIK-NKNNFIQTKSIP 997
Query: 449 TGNNEYINDPMAP-EIVNI-VEPMVGLYEGSAEMSSDLHSLATFIYNSHPDKNFPARNRA 506
NE + + P + ++ V G YE + + + P K+ RNR+
Sbjct: 998 KSENECVFVQLVPGRLYSVTVTTKSGQYEANEQGNGRTIP--------EPVKDLTLRNRS 1049
Query: 507 EDQTSPVVTTRNQYITDIAAEQLSYVIRRLVPFTEHMISVSA---FTIMGEGPPTVLSVR 563
+ + N + + L ++ PF H+++ + FT + G + V
Sbjct: 1050 TEDLHVTWSGANGDVDQYEIQLLFNDMKVFPPF--HLVNTATEYRFTSLTPGRQYKILVL 1107
Query: 564 TRQ------------QVPSSIKIINYK-NISSSSILLYWDPPEYPNGKITHYTIYAMELD 610
T VPS++K I+ N ++ S+ + W P G + YT+ A
Sbjct: 1108 TISGDVQQSAFIEGFTVPSAVKNIHISPNGATDSLTVNWTPG---GGDVDSYTVSAFRHS 1164
Query: 611 TNRAFQITTIDNSFLITGLKKYTKYKMRVAASTHVGESSLSE--ENDIFVRTSEDEPESS 668
+D+ + + ++T +++ + +S+S +N I V P S
Sbjct: 1165 QK-------VDSQTIPKHVFEHTFHRLEAGEQYQIMIASVSGSLKNQINV-VGRTVPASV 1216
Query: 669 PQDVEVIDVTADEIRLKWSPPEKPNGIIIAYEVLYKNIDTLYMKNTS----TTDIILRNL 724
+ ++ + + W +K G+ Y++L + + ++NTS T +L
Sbjct: 1217 QGVIADNAYSSYSLIVSW---QKAAGVAERYDILLLTENGILLRNTSEPATTKQHKFEDL 1273
Query: 725 RPHTLYNISVRSYTRFGHGNQVSSLLSVRTSETVPDSAPENITYKNISSGEIELSFLPPS 784
P Y I + + VS L + ++T + P +T I+ +
Sbjct: 1274 TPGKKYKIQILT---------VSGGLFSKEAQTEGRTVPAAVTDLRITENSTRHLSFRWT 1324
Query: 785 SPNGIIQKYTIYLKRSNGNEERTINTTSLTQNIKVLKKYTQYIIEVSASTLKGEGVRSAP 844
+ G + Y I+L +GN + L Q+ + ++ T GE
Sbjct: 1325 ASEGELSWYNIFLYNPDGNLQERAQVDPLVQSFSFQNLLQGRMYKMVIVTHSGELSNE-- 1382
Query: 845 ISILTEEDAPDSPPQDFSVKQLSGVTVKLSWQPPLEPNGIILYYTVYVWNRSSLKTINVT 904
S + P S + + ++ +W P +G +Y + ++N + K N
Sbjct: 1383 -SFIFGRTVPASVSHLRGSNRNTTDSLWFNWSPA---SGDFDFYELILYNPNGTKKENWK 1438
Query: 905 ETSLELSDLDYNVEYSAYVT-ASTRFGDGKTRSNIISFQTPEGAPSDPPKDVYYANLSSS 963
+ L V YV T GD SN ++ ++ APS PP + +A+++++
Sbjct: 1439 DKDLTEWRFQGLVPGRKYVLWVVTHSGD---LSNKVTAES-RTAPS-PPSLMSFADIANT 1493
Query: 964 SIILFWTPP 972
S+ + W P
Sbjct: 1494 SLAITWKGP 1502
Score = 45.4 bits (106), Expect = 6e-04
Identities = 35/167 (20%), Positives = 70/167 (41%), Gaps = 18/167 (10%)
Query: 17 TQVDVSNVVPGTRYDITISSISTTYTSPVTRIVTTNVTKPGPPVFLAGERVGSAGILLSW 76
T+ +VPG +Y + + + S ++ VT + T P PP ++ + + + ++W
Sbjct: 1443 TEWRFQGLVPGRKYVLWVVTHSGDLSNKVT---AESRTAPSPPSLMSFADIANTSLAITW 1499
Query: 77 NTPPNPNGRIISYIVKYKEV-CPWMQ----TVYTQVRSKPDSLEVLLTNLNPGTTYEIKV 131
PP+ Y + W+ TV+ ++ ++ L PG +Y+ V
Sbjct: 1500 KGPPD--------WTDYNDFELQWLPRDALTVFNPYNNRKSEGRIVY-GLRPGRSYQFNV 1550
Query: 132 AAENSAGIGVFSDPFLFQTAESAPGKVVNLTVEAYNASAVKLIWYLP 178
+ +S P +F + + P K+ NL N++A+ W P
Sbjct: 1551 KTVSGDSWKTYSKP-IFGSVRTKPDKIQNLHCRPQNSTAIACSWIPP 1596
Score = 38.9 bits (89), Expect = 0.059
Identities = 52/257 (20%), Positives = 112/257 (43%), Gaps = 37/257 (14%)
Query: 569 PSSIKIINYKNISSSSILLYWD-PPEYPNGKITHYTIYAMELDTNRAFQITTIDNSF--- 624
PS ++++ +I+++S+ + W PP++ T Y + ++ A + N+
Sbjct: 1479 PSPPSLMSFADIANTSLAITWKGPPDW-----TDYNDFELQWLPRDALTVFNPYNNRKSE 1533
Query: 625 --LITGLKKYTKYKMRVAASTHVGESSLSEENDIF--VRTSEDEPESSPQDVEVIDVTAD 680
++ GL+ Y+ V T G+S + IF VRT D+ Q++ +
Sbjct: 1534 GRIVYGLRPGRSYQFNV--KTVSGDSWKTYSKPIFGSVRTKPDKI----QNLHCRPQNST 1587
Query: 681 EIRLKWSPPEKPNGIIIAYEVLYKNIDTLYM-------KNTSTTDIILRNLRPHTLYNIS 733
I W PP+ Y + + +DT + K S +I++ L PH Y +S
Sbjct: 1588 AIACSWIPPDSD---FDGYSIECRKMDTQEVEFSRKLEKEKSLLNIMM--LVPHKRYLVS 1642
Query: 734 VRSYTRFGHGNQVSSLLSVRTSETVPDSAPE-NITYKNISSGEIELSFLPP----SSPNG 788
++ + G ++V ++ + P P + K++ + ++F S NG
Sbjct: 1643 IKVQSA-GMTSEVVEDSTITMIDRPPPPPPHIRVNEKDVLISKSSINFTVNCSWFSDTNG 1701
Query: 789 IIQKYTIYLKRSNGNEE 805
++ +T+ ++ ++G++E
Sbjct: 1702 AVKYFTVVVREADGSDE 1718
Score = 31.6 bits (70), Expect = 9.4
Identities = 56/234 (23%), Positives = 95/234 (40%), Gaps = 40/234 (17%)
Query: 1234 FFYTDESVPLAPPQ--NLTLIN--CTSDFVWLKWSPSPLPGGIVKVYSFKIHEHETDTIY 1289
F T E LA P+ N TL +S V ++W P +YS +DT+
Sbjct: 230 FSSTTEETGLAEPERCNFTLAESKASSHSVSIQWRILGSPCNFSLIYS-------SDTLG 282
Query: 1290 YKNISGFKTEAKLVG-----LEPVSTYSIRVSAFTKVGNGNQFSNVVKFTTQESVPDVVQ 1344
F+ + G L+ + Y+ R+ + ++ VV T + +P
Sbjct: 283 AALCPTFRIDNTTYGCNLQDLQAGTIYNFRIISL------DEERTVVLQT--DPLPPARF 334
Query: 1345 NMQCMATSWQSVLVKWDPPKKANGIITQYMVTV-ERNSTKV-------SPQDHMYTFIKL 1396
+ T+ S+ V W P ++G +T Y V + + N+ K+ S + YTF L
Sbjct: 335 GVSKEKTTSTSLHVWWTP---SSGKVTSYEVQLFDENNQKIQGVQIQESTSWNEYTFFNL 391
Query: 1397 LANTSYVFKVRASTSAGEGDESTCHVSTLPETVPSVPTNIAFSDVQSTSATLTW 1450
A + Y + +A G + + V T TVPS +I S ++ S ++W
Sbjct: 392 TAGSKY----NIAITAVSGGKRSFSVYTNGSTVPSPVKDIGIS-TKANSLLISW 440
>gi|157952213 protein tyrosine phosphatase, receptor type, B isoform b
precursor [Homo sapiens]
Length = 1997
Score = 296 bits (758), Expect = 2e-79
Identities = 388/1552 (25%), Positives = 656/1552 (42%), Gaps = 191/1552 (12%)
Query: 761 SAPENITYKNISS-GEIELSFLPPSSPNGIIQKYTIYLKRSNGN-EERTINTTSLTQNIK 818
+ P +T ++++ G F + G ++ Y + L N + +I++ + +
Sbjct: 552 TVPAQVTDLHVANQGMTSSLFTNWTQAQGDVEFYQVLLIHENVVIKNESISSETSRYSFH 611
Query: 819 VLKKYTQYIIEVSASTLKGEGVRSAPISILTEEDAPDSPPQDFSVKQLSGVTVK------ 872
LK + Y + V+ T+ G G+ S + ++ P S +SGVTV
Sbjct: 612 SLKSGSLYSVVVT--TVSG-GISSRQV-VVEGRTVPSS---------VSGVTVNNSGRND 658
Query: 873 ---LSWQPPLEPNGIILYYTVYVWNRSSLKTINVTETSLELSDLDYNVEYSAYVTASTRF 929
+SW L P + Y + ++++ + ++ E S VT +TR
Sbjct: 659 YLSVSWL--LAPGDVDNYEVTLSHDGKVVQSLVIAKSVRECSFSSLTPGRLYTVTITTRS 716
Query: 930 GDGKTRSNIISFQTPEGAPSDPPKDVYYANLSSSSII-LFWTPPSKPNGIIQYYSVYYRN 988
G + S F P D + V +N + S + + W + G +Y V +N
Sbjct: 717 GKYENHS----FSQERTVP-DKVQGVSVSNSARSDYLRVSWVHAT---GDFDHYEVTIKN 768
Query: 989 TSGTFMQNFTLHEVTNDFDNMTVSTIIDKLTIFSYYTFWLTASTSVGNGNKSSDIIEVYT 1048
+ F+Q ++ + N+ + +L Y+ +T + N+ +
Sbjct: 769 KNN-FIQTKSIPKSENE-------CVFVQLVPGRLYSVTVTTKSGQYEANEQGN------ 814
Query: 1049 DQDIPEGFVGNLTYESISSTAINVSWVPPAQPNGLVFYYVSLILQQTPRHVRPP--LVTY 1106
+ IPE V +LT + S+ ++V+W + NG V Y +L + V PP LV
Sbjct: 815 GRTIPEP-VKDLTLRNRSTEDLHVTW---SGANGDVDQYEIQLLFNDMK-VFPPFHLVNT 869
Query: 1107 ERSIYFDNLEKYTDY-ILKITPS---TEKGFSDTYTAQLYIKTEEDVPETSPIINTFKNL 1162
F +L Y IL +T S + F + +T VP I+ N
Sbjct: 870 ATEYRFTSLTPGRQYKILVLTISGDVQQSAFIEGFT----------VPSAVKNIHISPNG 919
Query: 1163 SSTSVLLSWDPPVKPNGAIISYDLTLQGPNENYSFITSDNYII---LEELSPFTLYSFFA 1219
++ S+ ++W P G + SY ++ ++ T ++ L Y
Sbjct: 920 ATDSLTVNWTPG---GGDVDSYTVSAFRHSQKVDSQTIPKHVFEHTFHRLEAGEQYQIMI 976
Query: 1220 AARTRKGLGPSSILFFYTDESVPLAPPQNLTLINCTSDF-VWLKWSPSPLPGGIVKVYSF 1278
A+ + +++ +VP A Q + N S + + + W + G+ + Y
Sbjct: 977 ASVSGSLKNQINVV----GRTVP-ASVQGVIADNAYSSYSLIVSWQKA---AGVAERYDI 1028
Query: 1279 KIHEHETDTIYYKNISGFKTEAKLVGLEPVSTYSIRVSAFTKVGNGNQFSNVVKFTTQES 1338
+ + + + K L P Y I++ + G FS + T +
Sbjct: 1029 LLLTENGILLRNTSEPATTKQHKFEDLTPGKKYKIQILTVS----GGLFSKEAQ-TEGRT 1083
Query: 1339 VPDVVQNMQCMATSWQSVLVKWDPPKKANGIITQYMVTVERN---STKVSPQDHMYTFIK 1395
VP V +++ S + + +W + ++ + N +V P ++F
Sbjct: 1084 VPAAVTDLRITENSTRHLSFRWTASEGELSWYNIFLYNPDGNLQERAQVDPLVQSFSFQN 1143
Query: 1396 LLANTSYVFKVRASTSAGE-GDESTCHVSTLPETVPSVPTNIAFSDVQSTSATLTWIRPD 1454
LL Y K+ T +GE +ES T+P +V +++ S+ +T + W
Sbjct: 1144 LLQGRMY--KMVIVTHSGELSNESFIFGRTVPASV----SHLRGSNRNTTDSL--WFNWS 1195
Query: 1455 TILGYFQNYK-ITTQLRAQKCKEWESEECVEYQKIQYLYEAHLTEETVYGLKKFRWYRFQ 1513
G F Y+ I K + W+ ++ LTE GL R Y
Sbjct: 1196 PASGDFDFYELILYNPNGTKKENWKDKD--------------LTEWRFQGLVPGRKYVLW 1241
Query: 1514 VAASTNAGYGNASNWISTKTLPGPPDGPPENVHVVATSPFSISISWSEPAVITGPTCYLI 1573
V + G+ SN ++ ++ P PP + + S++I+W P T +
Sbjct: 1242 VVTHS----GDLSNKVTAESRTAP--SPPSLMSFADIANTSLAITWKGPPDWTDYNDF-- 1293
Query: 1574 DVKSVDNDEFNISFIKSNEENKTIEIKDLEIFTRYSVVITAFTGNISAAYVEGKSSAEMI 1633
+++ + D + +N +++ + L Y + +G+ K+ ++ I
Sbjct: 1294 ELQWLPRDALTVFNPYNNRKSEGRIVYGLRPGRSYQFNVKTVSGD------SWKTYSKPI 1347
Query: 1634 VTTLESAPKDPPNNMTFQKIPDEVTKFQLTFLPPSQPNGNIQVYQALVYREDDPTAVQIH 1693
++ + P D N+ + P T +++PP + + Y ++ R+ D V+
Sbjct: 1348 FGSVRTKP-DKIQNLHCR--PQNSTAIACSWIPP---DSDFDGY-SIECRKMDTQEVEFS 1400
Query: 1694 NLSIIQKTNTFVIAMLEGLKGGHTYNISVYAVNSAGAGPKVPMRITMDIKAPARPKTKPT 1753
++K + + M+ L Y +S+ V SAG +V T I RP P
Sbjct: 1401 RK--LEKEKSLLNIMM--LVPHKRYLVSI-KVQSAGMTSEVVEDST--ITMIDRPPPPPP 1453
Query: 1754 PIYDATGKLLVTSTTITIRMPICYYSDDHGPIKNVQVLVTETGAQHDGNVTKW-----YD 1808
I +L++ ++I + ++SD +G +K V+V E + + Y
Sbjct: 1454 HIRVNEKDVLISKSSINFTVNCSWFSDTNGAVKYFTVVVREADGSDELKPEQQHPLPSYL 1513
Query: 1809 AYFNKA--RPYFTNEGFPNPPCTEGKTKFSGNEEIYIIGADNACM---IPGNEDKICNGP 1863
Y + A R Y TN + C E S + I + GA+ + + K C+GP
Sbjct: 1514 EYRHNASIRVYQTN--YFASKCAENPNSNSKSFNIKL-GAEMESLGGKCDPTQQKFCDGP 1570
Query: 1864 LKPKKQYLFKFRA-----TNIMGQFTDSDYSD-----PVKTLGEGLSERTVEIILSVTLC 1913
LKP Y RA + +FT YSD P+ T E L + S L
Sbjct: 1571 LKPHTAYRISIRAFTQLFDEDLKEFTKPLYSDTFFSLPITTESEPLFGAIEGV--SAGLF 1628
Query: 1914 ILSIILLGTAIFAFARIRQKQKEGGTYSPQDAEIIDTKLKLDQLITVADLELKDERLTRL 1973
++ +++ A+ A RQK G ++ ++ D+ ++V L L +
Sbjct: 1629 LIGMLV---AVVALLICRQKVSHG-----RERPSARLSIRRDRPLSV-HLNLGQK----- 1674
Query: 1974 LSYRKSIKPISKKSFLQHVEELCTNNNLKFQEEFSELPKFLQDLSSTDADLPWNRAKNRF 2033
RK+ PI F H +L ++N +E+ EL ++ S A LP NR KNR+
Sbjct: 1675 -GNRKTSCPIKINQFEGHFMKLQADSNYLLSKEYEELKDVGRNQSCDIALLPENRGKNRY 1733
Query: 2034 PNIKPYNNNRVKLIADASVPGSDYINASYISGYLCPNEFIATQGPLPGTVGDFWRMVWET 2093
NI PY+ RVKL P SDYINASYI G E+I TQGPLPGT DFW+MVWE
Sbjct: 1734 NNILPYDATRVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPGTKDDFWKMVWEQ 1793
Query: 2094 RAKTLVMLTQCFEKGRIRCHQYWPEDNKPVTVFGDIVITKLMEDVQIDWTIRDLKI---E 2150
+VM+TQC EKGR++C YWP D + +GD+++ L E V +WTIR+ KI E
Sbjct: 1794 NVHNIVMVTQCVEKGRVKCDHYWPADQDSL-YYGDLILQMLSESVLPEWTIREFKICGEE 1852
Query: 2151 RHGDCMTVRQCNFTAWPEHGVPENSAPLIHFVKLVR--ASRAHDTTPMIVHCSAGVGRTG 2208
+ +R ++T WP+HGVPE + LI FV+ VR +R+ P +VHCSAGVGRTG
Sbjct: 1853 QLDAHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPGAGPTVVHCSAGVGRTG 1912
Query: 2209 VFIALDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLL 2260
FIALD + Q ++ D VDIYG V +LR R+ MVQ QY++LHQC+ D+L
Sbjct: 1913 TFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRDVL 1964
Score = 53.5 bits (127), Expect = 2e-06
Identities = 197/1029 (19%), Positives = 377/1029 (36%), Gaps = 158/1029 (15%)
Query: 17 TQVDVSNVVPGTRYDITISSISTTYTSPVTRIVTTNVTKPGPPVFLAGERVGSAGILLSW 76
T+ +VPG Y +T+S +S ++ + T K
Sbjct: 341 TETHFKELVPGRLYQVTVSCVSGELSAQKMAVGRTFPDKVA------------------- 381
Query: 77 NTPPNPNGRIISYIVKYKEVC-PWMQ---------TVYTQVRSKPDSLEVLL--TNLNPG 124
N N NGR+ S +V + W Q V + + + ++ T L PG
Sbjct: 382 NLEANNNGRMRSLVVSWSPPAGDWEQYRILLFNDSVVLLNITVGKEETQYVMDDTGLVPG 441
Query: 125 TTYEIKVAAENSAGIGVFSDPFLFQTAESAPGKVVNLTVEAYNASAVKLIWYLPRQPNGK 184
YE++V E+ G + Q + P V+ L V+ N +++ ++W + P +
Sbjct: 442 RQYEVEVIVES----GNLKNSERCQ-GRTVPLAVLQLRVKHANETSLSIMW---QTPVAE 493
Query: 185 ITSFKISVKHARSGIVVKDVS-----IRVEDILTGKLPECN--------ENSESFLWSTA 231
+ IS+ ++ K +S D++ G+ +NS S T
Sbjct: 494 WEKYIISLADRDLLLIHKSLSKDAKEFTFTDLVPGRKYMATVTSISGDLKNSSSVKGRTV 553
Query: 232 SPSPTLGRVTPPSRTTHSSSTLTQ-------------NEISSVWKEPISFVVTHLRPYTT 278
T V T+ + TQ +E + E IS + ++
Sbjct: 554 PAQVTDLHVANQGMTSSLFTNWTQAQGDVEFYQVLLIHENVVIKNESISSETSRYSFHSL 613
Query: 279 Y---LFEVSAATTEAGYIDSTIVRTPESVPEGPPQNCVTGNITGKS--FSILWDPPTIVT 333
L+ V T G +V +VP + VT N +G++ S+ W +
Sbjct: 614 KSGSLYSVVVTTVSGGISSRQVVVEGRTVPSSV--SGVTVNNSGRNDYLSVSW---LLAP 668
Query: 334 GKF-SYRVELYGPSGRILDN---STKDLKFAFTNLTPFTMYDVYIAAETSAGTGPKSNIS 389
G +Y V L G+++ + + + +F++LTP +Y V I + G N S
Sbjct: 669 GDVDNYEVTL-SHDGKVVQSLVIAKSVRECSFSSLTPGRLYTVTITTRS----GKYENHS 723
Query: 390 VFTPPDVPGAVFDLQLAE-VESTQVRITWKKPRQPNGIINQYRVKVLVPETGIILENTLL 448
VP V + ++ S +R++W G + Y V + + I ++
Sbjct: 724 FSQERTVPDKVQGVSVSNSARSDYLRVSWV---HATGDFDHYEVTIK-NKNNFIQTKSIP 779
Query: 449 TGNNEYINDPMAP-EIVNI-VEPMVGLYEGSAEMSSDLHSLATFIYNSHPDKNFPARNRA 506
NE + + P + ++ V G YE + + + P K+ RNR+
Sbjct: 780 KSENECVFVQLVPGRLYSVTVTTKSGQYEANEQGNGRTIP--------EPVKDLTLRNRS 831
Query: 507 EDQTSPVVTTRNQYITDIAAEQLSYVIRRLVPFTEHMISVSA---FTIMGEGPPTVLSVR 563
+ + N + + L ++ PF H+++ + FT + G + V
Sbjct: 832 TEDLHVTWSGANGDVDQYEIQLLFNDMKVFPPF--HLVNTATEYRFTSLTPGRQYKILVL 889
Query: 564 TRQ------------QVPSSIKIINYK-NISSSSILLYWDPPEYPNGKITHYTIYAMELD 610
T VPS++K I+ N ++ S+ + W P G + YT+ A
Sbjct: 890 TISGDVQQSAFIEGFTVPSAVKNIHISPNGATDSLTVNWTPG---GGDVDSYTVSAFRHS 946
Query: 611 TNRAFQITTIDNSFLITGLKKYTKYKMRVAASTHVGESSLSE--ENDIFVRTSEDEPESS 668
+D+ + + ++T +++ + +S+S +N I V P S
Sbjct: 947 QK-------VDSQTIPKHVFEHTFHRLEAGEQYQIMIASVSGSLKNQINV-VGRTVPASV 998
Query: 669 PQDVEVIDVTADEIRLKWSPPEKPNGIIIAYEVLYKNIDTLYMKNTS----TTDIILRNL 724
+ ++ + + W +K G+ Y++L + + ++NTS T +L
Sbjct: 999 QGVIADNAYSSYSLIVSW---QKAAGVAERYDILLLTENGILLRNTSEPATTKQHKFEDL 1055
Query: 725 RPHTLYNISVRSYTRFGHGNQVSSLLSVRTSETVPDSAPENITYKNISSGEIELSFLPPS 784
P Y I + + VS L + ++T + P +T I+ +
Sbjct: 1056 TPGKKYKIQILT---------VSGGLFSKEAQTEGRTVPAAVTDLRITENSTRHLSFRWT 1106
Query: 785 SPNGIIQKYTIYLKRSNGNEERTINTTSLTQNIKVLKKYTQYIIEVSASTLKGEGVRSAP 844
+ G + Y I+L +GN + L Q+ + ++ T GE
Sbjct: 1107 ASEGELSWYNIFLYNPDGNLQERAQVDPLVQSFSFQNLLQGRMYKMVIVTHSGELSNE-- 1164
Query: 845 ISILTEEDAPDSPPQDFSVKQLSGVTVKLSWQPPLEPNGIILYYTVYVWNRSSLKTINVT 904
S + P S + + ++ +W P +G +Y + ++N + K N
Sbjct: 1165 -SFIFGRTVPASVSHLRGSNRNTTDSLWFNWSPA---SGDFDFYELILYNPNGTKKENWK 1220
Query: 905 ETSLELSDLDYNVEYSAYVT-ASTRFGDGKTRSNIISFQTPEGAPSDPPKDVYYANLSSS 963
+ L V YV T GD SN ++ ++ APS PP + +A+++++
Sbjct: 1221 DKDLTEWRFQGLVPGRKYVLWVVTHSGD---LSNKVTAES-RTAPS-PPSLMSFADIANT 1275
Query: 964 SIILFWTPP 972
S+ + W P
Sbjct: 1276 SLAITWKGP 1284
Score = 45.4 bits (106), Expect = 6e-04
Identities = 35/167 (20%), Positives = 70/167 (41%), Gaps = 18/167 (10%)
Query: 17 TQVDVSNVVPGTRYDITISSISTTYTSPVTRIVTTNVTKPGPPVFLAGERVGSAGILLSW 76
T+ +VPG +Y + + + S ++ VT + T P PP ++ + + + ++W
Sbjct: 1225 TEWRFQGLVPGRKYVLWVVTHSGDLSNKVT---AESRTAPSPPSLMSFADIANTSLAITW 1281
Query: 77 NTPPNPNGRIISYIVKYKEV-CPWMQ----TVYTQVRSKPDSLEVLLTNLNPGTTYEIKV 131
PP+ Y + W+ TV+ ++ ++ L PG +Y+ V
Sbjct: 1282 KGPPD--------WTDYNDFELQWLPRDALTVFNPYNNRKSEGRIVY-GLRPGRSYQFNV 1332
Query: 132 AAENSAGIGVFSDPFLFQTAESAPGKVVNLTVEAYNASAVKLIWYLP 178
+ +S P +F + + P K+ NL N++A+ W P
Sbjct: 1333 KTVSGDSWKTYSKP-IFGSVRTKPDKIQNLHCRPQNSTAIACSWIPP 1378
Score = 38.9 bits (89), Expect = 0.059
Identities = 52/257 (20%), Positives = 112/257 (43%), Gaps = 37/257 (14%)
Query: 569 PSSIKIINYKNISSSSILLYWD-PPEYPNGKITHYTIYAMELDTNRAFQITTIDNSF--- 624
PS ++++ +I+++S+ + W PP++ T Y + ++ A + N+
Sbjct: 1261 PSPPSLMSFADIANTSLAITWKGPPDW-----TDYNDFELQWLPRDALTVFNPYNNRKSE 1315
Query: 625 --LITGLKKYTKYKMRVAASTHVGESSLSEENDIF--VRTSEDEPESSPQDVEVIDVTAD 680
++ GL+ Y+ V T G+S + IF VRT D+ Q++ +
Sbjct: 1316 GRIVYGLRPGRSYQFNV--KTVSGDSWKTYSKPIFGSVRTKPDKI----QNLHCRPQNST 1369
Query: 681 EIRLKWSPPEKPNGIIIAYEVLYKNIDTLYM-------KNTSTTDIILRNLRPHTLYNIS 733
I W PP+ Y + + +DT + K S +I++ L PH Y +S
Sbjct: 1370 AIACSWIPPDSD---FDGYSIECRKMDTQEVEFSRKLEKEKSLLNIMM--LVPHKRYLVS 1424
Query: 734 VRSYTRFGHGNQVSSLLSVRTSETVPDSAPE-NITYKNISSGEIELSFLPP----SSPNG 788
++ + G ++V ++ + P P + K++ + ++F S NG
Sbjct: 1425 IKVQSA-GMTSEVVEDSTITMIDRPPPPPPHIRVNEKDVLISKSSINFTVNCSWFSDTNG 1483
Query: 789 IIQKYTIYLKRSNGNEE 805
++ +T+ ++ ++G++E
Sbjct: 1484 AVKYFTVVVREADGSDE 1500
>gi|13677220 receptor-type protein tyrosine phosphatase O isoform d
precursor [Homo sapiens]
Length = 377
Score = 286 bits (732), Expect = 2e-76
Identities = 156/388 (40%), Positives = 222/388 (57%), Gaps = 20/388 (5%)
Query: 1899 LSERTVEIILSVTLCILSIILLGTAIFAFARIRQKQKEGGTYSPQDAEIIDTKLKLDQLI 1958
++E +++ L ILS +L+G + +R+K + + + +
Sbjct: 2 VTEMNPNVVVISVLAILSTLLIGLLLVTLIILRKKHLQ-----------MARECGAGTFV 50
Query: 1959 TVADLELKDERLT-----RLLSYRKSIKPISKKSFLQHVEELCTNNNLKFQEEFSELPKF 2013
A LE +D +L L RK P+ F +++++ +++ KF +F EL
Sbjct: 51 NFASLE-RDGKLPYNWSKNGLKKRKLTNPVQLDDFDAYIKDMAKDSDYKFSLQFEELKLI 109
Query: 2014 LQDLSSTDADLPWNRAKNRFPNIKPYNNNRVKLIADASVPGSDYINASYISGYLCPNEFI 2073
D+ ADLP NR KNR+ NI PY+ +RV+L++ G+DYINA+YI GY P E+I
Sbjct: 110 GLDIPHFAADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYI 169
Query: 2074 ATQGPLPGTVGDFWRMVWETRAKTLVMLTQCFEKGRIRCHQYWPEDNKPVTVFGDIVITK 2133
ATQGPLP T DFW+MV + +++ +VMLTQC EK R++C YWP +P+ +GDI +
Sbjct: 170 ATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPI-AYGDITVEM 228
Query: 2134 LMEDVQIDWTIRDLKIERHGDCMTVRQCNFTAWPEHGVPENSA--PLIHFVKLVRASRAH 2191
+ E+ Q DW R +I + V N+TAWP+HGVP +A ++ FV +VR
Sbjct: 229 ISEEEQDDWACRHFRINYADEMQDVMHFNYTAWPDHGVPTANAAESILQFVHMVRQQATK 288
Query: 2192 DTTPMIVHCSAGVGRTGVFIALDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIF 2251
PMI+HCSAGVGRTG FIALD L QHI DH+FVDI GLV+E+RS RM MVQ QYIF
Sbjct: 289 SKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIF 348
Query: 2252 LHQCILDLLSNKGSNQPICFVNYSALQK 2279
+HQC+ + K I V Y + K
Sbjct: 349 IHQCVQLMWMKKKQQFCISDVIYENVSK 376
>gi|13677216 receptor-type protein tyrosine phosphatase O isoform d
precursor [Homo sapiens]
Length = 377
Score = 286 bits (732), Expect = 2e-76
Identities = 156/388 (40%), Positives = 222/388 (57%), Gaps = 20/388 (5%)
Query: 1899 LSERTVEIILSVTLCILSIILLGTAIFAFARIRQKQKEGGTYSPQDAEIIDTKLKLDQLI 1958
++E +++ L ILS +L+G + +R+K + + + +
Sbjct: 2 VTEMNPNVVVISVLAILSTLLIGLLLVTLIILRKKHLQ-----------MARECGAGTFV 50
Query: 1959 TVADLELKDERLT-----RLLSYRKSIKPISKKSFLQHVEELCTNNNLKFQEEFSELPKF 2013
A LE +D +L L RK P+ F +++++ +++ KF +F EL
Sbjct: 51 NFASLE-RDGKLPYNWSKNGLKKRKLTNPVQLDDFDAYIKDMAKDSDYKFSLQFEELKLI 109
Query: 2014 LQDLSSTDADLPWNRAKNRFPNIKPYNNNRVKLIADASVPGSDYINASYISGYLCPNEFI 2073
D+ ADLP NR KNR+ NI PY+ +RV+L++ G+DYINA+YI GY P E+I
Sbjct: 110 GLDIPHFAADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYI 169
Query: 2074 ATQGPLPGTVGDFWRMVWETRAKTLVMLTQCFEKGRIRCHQYWPEDNKPVTVFGDIVITK 2133
ATQGPLP T DFW+MV + +++ +VMLTQC EK R++C YWP +P+ +GDI +
Sbjct: 170 ATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPI-AYGDITVEM 228
Query: 2134 LMEDVQIDWTIRDLKIERHGDCMTVRQCNFTAWPEHGVPENSA--PLIHFVKLVRASRAH 2191
+ E+ Q DW R +I + V N+TAWP+HGVP +A ++ FV +VR
Sbjct: 229 ISEEEQDDWACRHFRINYADEMQDVMHFNYTAWPDHGVPTANAAESILQFVHMVRQQATK 288
Query: 2192 DTTPMIVHCSAGVGRTGVFIALDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIF 2251
PMI+HCSAGVGRTG FIALD L QHI DH+FVDI GLV+E+RS RM MVQ QYIF
Sbjct: 289 SKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIF 348
Query: 2252 LHQCILDLLSNKGSNQPICFVNYSALQK 2279
+HQC+ + K I V Y + K
Sbjct: 349 IHQCVQLMWMKKKQQFCISDVIYENVSK 376
>gi|4506323 receptor-type protein tyrosine phosphatase O isoform b
precursor [Homo sapiens]
Length = 1188
Score = 286 bits (732), Expect = 2e-76
Identities = 156/388 (40%), Positives = 222/388 (57%), Gaps = 20/388 (5%)
Query: 1899 LSERTVEIILSVTLCILSIILLGTAIFAFARIRQKQKEGGTYSPQDAEIIDTKLKLDQLI 1958
++E +++ L ILS +L+G + +R+K + + + +
Sbjct: 813 VTEMNPNVVVISVLAILSTLLIGLLLVTLIILRKKHLQ-----------MARECGAGTFV 861
Query: 1959 TVADLELKDERLT-----RLLSYRKSIKPISKKSFLQHVEELCTNNNLKFQEEFSELPKF 2013
A LE +D +L L RK P+ F +++++ +++ KF +F EL
Sbjct: 862 NFASLE-RDGKLPYNWSKNGLKKRKLTNPVQLDDFDAYIKDMAKDSDYKFSLQFEELKLI 920
Query: 2014 LQDLSSTDADLPWNRAKNRFPNIKPYNNNRVKLIADASVPGSDYINASYISGYLCPNEFI 2073
D+ ADLP NR KNR+ NI PY+ +RV+L++ G+DYINA+YI GY P E+I
Sbjct: 921 GLDIPHFAADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYI 980
Query: 2074 ATQGPLPGTVGDFWRMVWETRAKTLVMLTQCFEKGRIRCHQYWPEDNKPVTVFGDIVITK 2133
ATQGPLP T DFW+MV + +++ +VMLTQC EK R++C YWP +P+ +GDI +
Sbjct: 981 ATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPI-AYGDITVEM 1039
Query: 2134 LMEDVQIDWTIRDLKIERHGDCMTVRQCNFTAWPEHGVPENSA--PLIHFVKLVRASRAH 2191
+ E+ Q DW R +I + V N+TAWP+HGVP +A ++ FV +VR
Sbjct: 1040 ISEEEQDDWACRHFRINYADEMQDVMHFNYTAWPDHGVPTANAAESILQFVHMVRQQATK 1099
Query: 2192 DTTPMIVHCSAGVGRTGVFIALDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIF 2251
PMI+HCSAGVGRTG FIALD L QHI DH+FVDI GLV+E+RS RM MVQ QYIF
Sbjct: 1100 SKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIF 1159
Query: 2252 LHQCILDLLSNKGSNQPICFVNYSALQK 2279
+HQC+ + K I V Y + K
Sbjct: 1160 IHQCVQLMWMKKKQQFCISDVIYENVSK 1187
Score = 44.3 bits (103), Expect = 0.001
Identities = 88/434 (20%), Positives = 168/434 (38%), Gaps = 56/434 (12%)
Query: 585 ILLYWDPPEYPNGKITHYTIYAMELDTNRAFQITTIDNSFLITGLKKYTKYKMRVAASTH 644
++L W PP+ P + I+ + + + + + LK+ KYK+ V +
Sbjct: 345 MILTWLPPKPPTA-FDGFHIHIEREENFTEYLMVDEEAHEFVAELKEPGKYKLSVTTFSS 403
Query: 645 VG-----ESSLSEENDIFVRTSED---EPESSPQDVEVIDVTADEIRLKW-SPPEKPNGI 695
G +S ++ ++ S + E PQ V V +++ + W S E N
Sbjct: 404 SGSCETRKSQSAKSLSFYISPSGEWIEELTEKPQHVSVHVLSSTTALMSWTSSQENYNST 463
Query: 696 IIAYEVLY-------KNIDTLYMKNTSTTDIILRNLRPHTLYNISVRSYTRFGHGNQVSS 748
I++ L + ++ Y +++ I+ NL P Y + + Y R G +
Sbjct: 464 IVSVVSLTCQKQKESQRLEKQYCTQVNSSKPIIENLVPGAQYQVVI--YLR--KGPLIGP 519
Query: 749 LLSVRTSETVPDSAPENITYKNISSGEIELSFLPPSSPNGIIQKYTI---YLKRSNGNEE 805
T VP + + Y + + LS+ P G+ +KY + Y + E
Sbjct: 520 PSDPVTFAIVPTGIKDLMLYP-LGPTAVVLSWTRPYL--GVFRKYVVEMFYFNPATMTSE 576
Query: 806 RTIN-----TTSLTQNIKV--LKKYTQYIIEVSASTLKGEGVRSAPISILTEEDAPDSPP 858
T T SLT ++++ L Y V+ T + S ++ AP +P
Sbjct: 577 WTTYYEIAATVSLTASVRIANLLPAWYYNFRVTMVTWGDPELSCCDSSTISFITAPVAP- 635
Query: 859 QDFSVKQLSGVTVKLSWQPPLEPNGI----ILYYTVYVWNRSSLK---TINVTETSLELS 911
+ SV+ + + + +SW + + +L++ V + +K T NV L L
Sbjct: 636 EITSVEYFNSL-LYISWTYGDDTTDLSHSRMLHWMVVAEGKKKIKKSVTRNVMTAILSLP 694
Query: 912 DLDYNVEYSAYVTASTRFGDGKTRSNIISFQTPEGAPSDPPKDVYYANLSSSSIILFWTP 971
D Y+ VTA T G + ++ + PPK ++ N + +S+ L W
Sbjct: 695 PGDI---YNLSVTACTERGSNTSMLRLVKLEPA------PPKSLFAVNKTQTSVTLLWV- 744
Query: 972 PSKPNGIIQYYSVY 985
G+ ++ V+
Sbjct: 745 ---EEGVADFFEVF 755
Score = 36.6 bits (83), Expect = 0.29
Identities = 83/418 (19%), Positives = 153/418 (36%), Gaps = 40/418 (9%)
Query: 869 VTVKLSWQPPLEPNGIILYYTVYVWNRSSLKTINVTETSLE-LSDLDYNVEYSAYVTAST 927
V + L+W PP P ++ + + + V E + E +++L +Y VT +
Sbjct: 343 VQMILTWLPPKPPTAFDGFHIHIEREENFTEYLMVDEEAHEFVAELKEPGKYKLSVTTFS 402
Query: 928 RFGDGKTRSN-----IISFQTPEGA----PSDPPKDVYYANLSSSSIILFWTPPSKPNGI 978
G +TR + + + +P G ++ P+ V LSS++ ++ WT +
Sbjct: 403 SSGSCETRKSQSAKSLSFYISPSGEWIEELTEKPQHVSVHVLSSTTALMSWTSSQE---- 458
Query: 979 IQYYSVYYRNTSGTFMQNFTLHEVTNDFDNMTVST--IIDKLTIFSYYTFWLTASTSVGN 1036
Y S S T + + + S+ II+ L + Y +
Sbjct: 459 -NYNSTIVSVVSLTCQKQKESQRLEKQYCTQVNSSKPIIENLVPGAQYQVVIYLRKGPLI 517
Query: 1037 GNKSSDIIEVYTDQDIPEGFVGNLTYESISSTAINVSWVPPAQPNGLVFYYVSLILQQTP 1096
G S + T +P G + Y + TA+ +SW P G+ YV + P
Sbjct: 518 GPPSDPV----TFAIVPTGIKDLMLYP-LGPTAVVLSWTRPYL--GVFRKYVVEMFYFNP 570
Query: 1097 RHVRPPLVTYER---------SIYFDNLEKYTDYILKITPST--EKGFSDTYTAQLYIKT 1145
+ TY S+ NL Y ++T T + S ++ + T
Sbjct: 571 ATMTSEWTTYYEIAATVSLTASVRIANLLPAWYYNFRVTMVTWGDPELSCCDSSTISFIT 630
Query: 1146 EEDVPETSPIINTFKNLSSTSVLLSWDPPVKPNGAIISYDLTLQGPNENYSFITSDNYII 1205
PE + + F +L S D + ++ + + +G + +T +
Sbjct: 631 APVAPEITSV-EYFNSLLYISWTYGDDTTDLSHSRMLHWMVVAEGKKKIKKSVTRNVMTA 689
Query: 1206 LEELSPFTLYSFFAAARTRKGLGPSSILFFYTDESVPLAPPQNLTLINCTSDFVWLKW 1263
+ L P +Y+ A T +G S + + APP++L +N T V L W
Sbjct: 690 ILSLPPGDIYNLSVTACTERGSNTSMLRLVKLEP----APPKSLFAVNKTQTSVTLLW 743
Score = 36.6 bits (83), Expect = 0.29
Identities = 29/113 (25%), Positives = 50/113 (44%), Gaps = 4/113 (3%)
Query: 67 VGSAGILLSW-NTPPNPNGRIISYIVKYKEVCPWMQTVYTQVRSKPDSLEVLLTNLNPGT 125
+ S L+SW ++ N N I+S + + Q + Q ++ +S + ++ NL PG
Sbjct: 444 LSSTTALMSWTSSQENYNSTIVSVVSLTCQKQKESQRLEKQYCTQVNSSKPIIENLVPGA 503
Query: 126 TYEIKVAAENSAGIGVFSDPFLFQTAESAPGKVVNLTVEAYNASAVKLIWYLP 178
Y++ + IG SDP F P + +L + +AV L W P
Sbjct: 504 QYQVVIYLRKGPLIGPPSDPVTFAI---VPTGIKDLMLYPLGPTAVVLSWTRP 553
>gi|13677222 receptor-type protein tyrosine phosphatase O isoform c
precursor [Homo sapiens]
Length = 405
Score = 283 bits (723), Expect = 2e-75
Identities = 142/308 (46%), Positives = 192/308 (62%), Gaps = 3/308 (0%)
Query: 1974 LSYRKSIKPISKKSFLQHVEELCTNNNLKFQEEFSELPKFLQDLSSTDADLPWNRAKNRF 2033
L RK P+ F +++++ +++ KF +F EL D+ ADLP NR KNR+
Sbjct: 98 LKKRKLTNPVQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRY 157
Query: 2034 PNIKPYNNNRVKLIADASVPGSDYINASYISGYLCPNEFIATQGPLPGTVGDFWRMVWET 2093
NI PY+ +RV+L++ G+DYINA+YI GY P E+IATQGPLP T DFW+MV +
Sbjct: 158 TNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQ 217
Query: 2094 RAKTLVMLTQCFEKGRIRCHQYWPEDNKPVTVFGDIVITKLMEDVQIDWTIRDLKIERHG 2153
+++ +VMLTQC EK R++C YWP +P+ +GDI + + E+ Q DW R +I
Sbjct: 218 KSQIIVMLTQCNEKRRVKCDHYWPFTEEPI-AYGDITVEMISEEEQDDWACRHFRINYAD 276
Query: 2154 DCMTVRQCNFTAWPEHGVPENSA--PLIHFVKLVRASRAHDTTPMIVHCSAGVGRTGVFI 2211
+ V N+TAWP+HGVP +A ++ FV +VR PMI+HCSAGVGRTG FI
Sbjct: 277 EMQDVMHFNYTAWPDHGVPTANAAESILQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFI 336
Query: 2212 ALDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLLSNKGSNQPICF 2271
ALD L QHI DH+FVDI GLV+E+RS RM MVQ QYIF+HQC+ + K I
Sbjct: 337 ALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKKKQQFCISD 396
Query: 2272 VNYSALQK 2279
V Y + K
Sbjct: 397 VIYENVSK 404
>gi|13677218 receptor-type protein tyrosine phosphatase O isoform c
precursor [Homo sapiens]
Length = 405
Score = 283 bits (723), Expect = 2e-75
Identities = 142/308 (46%), Positives = 192/308 (62%), Gaps = 3/308 (0%)
Query: 1974 LSYRKSIKPISKKSFLQHVEELCTNNNLKFQEEFSELPKFLQDLSSTDADLPWNRAKNRF 2033
L RK P+ F +++++ +++ KF +F EL D+ ADLP NR KNR+
Sbjct: 98 LKKRKLTNPVQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRY 157
Query: 2034 PNIKPYNNNRVKLIADASVPGSDYINASYISGYLCPNEFIATQGPLPGTVGDFWRMVWET 2093
NI PY+ +RV+L++ G+DYINA+YI GY P E+IATQGPLP T DFW+MV +
Sbjct: 158 TNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQ 217
Query: 2094 RAKTLVMLTQCFEKGRIRCHQYWPEDNKPVTVFGDIVITKLMEDVQIDWTIRDLKIERHG 2153
+++ +VMLTQC EK R++C YWP +P+ +GDI + + E+ Q DW R +I
Sbjct: 218 KSQIIVMLTQCNEKRRVKCDHYWPFTEEPI-AYGDITVEMISEEEQDDWACRHFRINYAD 276
Query: 2154 DCMTVRQCNFTAWPEHGVPENSA--PLIHFVKLVRASRAHDTTPMIVHCSAGVGRTGVFI 2211
+ V N+TAWP+HGVP +A ++ FV +VR PMI+HCSAGVGRTG FI
Sbjct: 277 EMQDVMHFNYTAWPDHGVPTANAAESILQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFI 336
Query: 2212 ALDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLLSNKGSNQPICF 2271
ALD L QHI DH+FVDI GLV+E+RS RM MVQ QYIF+HQC+ + K I
Sbjct: 337 ALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKKKQQFCISD 396
Query: 2272 VNYSALQK 2279
V Y + K
Sbjct: 397 VIYENVSK 404
>gi|13677214 receptor-type protein tyrosine phosphatase O isoform a
precursor [Homo sapiens]
Length = 1216
Score = 283 bits (723), Expect = 2e-75
Identities = 142/308 (46%), Positives = 192/308 (62%), Gaps = 3/308 (0%)
Query: 1974 LSYRKSIKPISKKSFLQHVEELCTNNNLKFQEEFSELPKFLQDLSSTDADLPWNRAKNRF 2033
L RK P+ F +++++ +++ KF +F EL D+ ADLP NR KNR+
Sbjct: 909 LKKRKLTNPVQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRY 968
Query: 2034 PNIKPYNNNRVKLIADASVPGSDYINASYISGYLCPNEFIATQGPLPGTVGDFWRMVWET 2093
NI PY+ +RV+L++ G+DYINA+YI GY P E+IATQGPLP T DFW+MV +
Sbjct: 969 TNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQ 1028
Query: 2094 RAKTLVMLTQCFEKGRIRCHQYWPEDNKPVTVFGDIVITKLMEDVQIDWTIRDLKIERHG 2153
+++ +VMLTQC EK R++C YWP +P+ +GDI + + E+ Q DW R +I
Sbjct: 1029 KSQIIVMLTQCNEKRRVKCDHYWPFTEEPI-AYGDITVEMISEEEQDDWACRHFRINYAD 1087
Query: 2154 DCMTVRQCNFTAWPEHGVPENSA--PLIHFVKLVRASRAHDTTPMIVHCSAGVGRTGVFI 2211
+ V N+TAWP+HGVP +A ++ FV +VR PMI+HCSAGVGRTG FI
Sbjct: 1088 EMQDVMHFNYTAWPDHGVPTANAAESILQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFI 1147
Query: 2212 ALDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLLSNKGSNQPICF 2271
ALD L QHI DH+FVDI GLV+E+RS RM MVQ QYIF+HQC+ + K I
Sbjct: 1148 ALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKKKQQFCISD 1207
Query: 2272 VNYSALQK 2279
V Y + K
Sbjct: 1208 VIYENVSK 1215
Score = 44.3 bits (103), Expect = 0.001
Identities = 88/434 (20%), Positives = 168/434 (38%), Gaps = 56/434 (12%)
Query: 585 ILLYWDPPEYPNGKITHYTIYAMELDTNRAFQITTIDNSFLITGLKKYTKYKMRVAASTH 644
++L W PP+ P + I+ + + + + + LK+ KYK+ V +
Sbjct: 345 MILTWLPPKPPTA-FDGFHIHIEREENFTEYLMVDEEAHEFVAELKEPGKYKLSVTTFSS 403
Query: 645 VG-----ESSLSEENDIFVRTSED---EPESSPQDVEVIDVTADEIRLKW-SPPEKPNGI 695
G +S ++ ++ S + E PQ V V +++ + W S E N
Sbjct: 404 SGSCETRKSQSAKSLSFYISPSGEWIEELTEKPQHVSVHVLSSTTALMSWTSSQENYNST 463
Query: 696 IIAYEVLY-------KNIDTLYMKNTSTTDIILRNLRPHTLYNISVRSYTRFGHGNQVSS 748
I++ L + ++ Y +++ I+ NL P Y + + Y R G +
Sbjct: 464 IVSVVSLTCQKQKESQRLEKQYCTQVNSSKPIIENLVPGAQYQVVI--YLR--KGPLIGP 519
Query: 749 LLSVRTSETVPDSAPENITYKNISSGEIELSFLPPSSPNGIIQKYTI---YLKRSNGNEE 805
T VP + + Y + + LS+ P G+ +KY + Y + E
Sbjct: 520 PSDPVTFAIVPTGIKDLMLYP-LGPTAVVLSWTRPYL--GVFRKYVVEMFYFNPATMTSE 576
Query: 806 RTIN-----TTSLTQNIKV--LKKYTQYIIEVSASTLKGEGVRSAPISILTEEDAPDSPP 858
T T SLT ++++ L Y V+ T + S ++ AP +P
Sbjct: 577 WTTYYEIAATVSLTASVRIANLLPAWYYNFRVTMVTWGDPELSCCDSSTISFITAPVAP- 635
Query: 859 QDFSVKQLSGVTVKLSWQPPLEPNGI----ILYYTVYVWNRSSLK---TINVTETSLELS 911
+ SV+ + + + +SW + + +L++ V + +K T NV L L
Sbjct: 636 EITSVEYFNSL-LYISWTYGDDTTDLSHSRMLHWMVVAEGKKKIKKSVTRNVMTAILSLP 694
Query: 912 DLDYNVEYSAYVTASTRFGDGKTRSNIISFQTPEGAPSDPPKDVYYANLSSSSIILFWTP 971
D Y+ VTA T G + ++ + PPK ++ N + +S+ L W
Sbjct: 695 PGDI---YNLSVTACTERGSNTSMLRLVKLEPA------PPKSLFAVNKTQTSVTLLWV- 744
Query: 972 PSKPNGIIQYYSVY 985
G+ ++ V+
Sbjct: 745 ---EEGVADFFEVF 755
Score = 36.6 bits (83), Expect = 0.29
Identities = 83/418 (19%), Positives = 153/418 (36%), Gaps = 40/418 (9%)
Query: 869 VTVKLSWQPPLEPNGIILYYTVYVWNRSSLKTINVTETSLE-LSDLDYNVEYSAYVTAST 927
V + L+W PP P ++ + + + V E + E +++L +Y VT +
Sbjct: 343 VQMILTWLPPKPPTAFDGFHIHIEREENFTEYLMVDEEAHEFVAELKEPGKYKLSVTTFS 402
Query: 928 RFGDGKTRSN-----IISFQTPEGA----PSDPPKDVYYANLSSSSIILFWTPPSKPNGI 978
G +TR + + + +P G ++ P+ V LSS++ ++ WT +
Sbjct: 403 SSGSCETRKSQSAKSLSFYISPSGEWIEELTEKPQHVSVHVLSSTTALMSWTSSQE---- 458
Query: 979 IQYYSVYYRNTSGTFMQNFTLHEVTNDFDNMTVST--IIDKLTIFSYYTFWLTASTSVGN 1036
Y S S T + + + S+ II+ L + Y +
Sbjct: 459 -NYNSTIVSVVSLTCQKQKESQRLEKQYCTQVNSSKPIIENLVPGAQYQVVIYLRKGPLI 517
Query: 1037 GNKSSDIIEVYTDQDIPEGFVGNLTYESISSTAINVSWVPPAQPNGLVFYYVSLILQQTP 1096
G S + T +P G + Y + TA+ +SW P G+ YV + P
Sbjct: 518 GPPSDPV----TFAIVPTGIKDLMLYP-LGPTAVVLSWTRPYL--GVFRKYVVEMFYFNP 570
Query: 1097 RHVRPPLVTYER---------SIYFDNLEKYTDYILKITPST--EKGFSDTYTAQLYIKT 1145
+ TY S+ NL Y ++T T + S ++ + T
Sbjct: 571 ATMTSEWTTYYEIAATVSLTASVRIANLLPAWYYNFRVTMVTWGDPELSCCDSSTISFIT 630
Query: 1146 EEDVPETSPIINTFKNLSSTSVLLSWDPPVKPNGAIISYDLTLQGPNENYSFITSDNYII 1205
PE + + F +L S D + ++ + + +G + +T +
Sbjct: 631 APVAPEITSV-EYFNSLLYISWTYGDDTTDLSHSRMLHWMVVAEGKKKIKKSVTRNVMTA 689
Query: 1206 LEELSPFTLYSFFAAARTRKGLGPSSILFFYTDESVPLAPPQNLTLINCTSDFVWLKW 1263
+ L P +Y+ A T +G S + + APP++L +N T V L W
Sbjct: 690 ILSLPPGDIYNLSVTACTERGSNTSMLRLVKLEP----APPKSLFAVNKTQTSVTLLW 743
Score = 36.6 bits (83), Expect = 0.29
Identities = 29/113 (25%), Positives = 50/113 (44%), Gaps = 4/113 (3%)
Query: 67 VGSAGILLSW-NTPPNPNGRIISYIVKYKEVCPWMQTVYTQVRSKPDSLEVLLTNLNPGT 125
+ S L+SW ++ N N I+S + + Q + Q ++ +S + ++ NL PG
Sbjct: 444 LSSTTALMSWTSSQENYNSTIVSVVSLTCQKQKESQRLEKQYCTQVNSSKPIIENLVPGA 503
Query: 126 TYEIKVAAENSAGIGVFSDPFLFQTAESAPGKVVNLTVEAYNASAVKLIWYLP 178
Y++ + IG SDP F P + +L + +AV L W P
Sbjct: 504 QYQVVIYLRKGPLIGPPSDPVTFAI---VPTGIKDLMLYPLGPTAVVLSWTRP 553
>gi|104487611 protein tyrosine phosphatase, receptor type, sigma
isoform 4 precursor [Homo sapiens]
Length = 1505
Score = 273 bits (697), Expect = 2e-72
Identities = 267/993 (26%), Positives = 431/993 (43%), Gaps = 102/993 (10%)
Query: 1335 TQESVPDVVQNMQCMATSWQSVLVKWDP--PKKANGIITQYMVTVERNSTKVSPQ--DHM 1390
T +S+P + S+ + WD P + + +Y + ++
Sbjct: 318 TVKSLPKAPGTPMVTENTATSITITWDSGNPDPVSYYVIEYKSKSQDGPYQIKEDITTTR 377
Query: 1391 YTFIKLLANTSYVFKVRASTSAGEGDESTCHVSTLPETVP-SVPTNIAFSDVQSTSATLT 1449
Y+ L N+ Y V A S G+G S V+ E P S P N+ + +T+ +
Sbjct: 378 YSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQ 437
Query: 1450 WIRPDTILGYFQNYKITTQLRAQKCKEWESEECVEYQKIQYLYEAHLTEETVYGLKKFRW 1509
W P G + Y++ + E E V + + ++ LT TV L +
Sbjct: 438 WEEPVEPNGLIRGYRVYYTM--------EPEHPVGNWQKHNVDDSLLT--TVGSLLEDET 487
Query: 1510 YRFQVAASTNAGYGNASNWISTKTLPGPPDGPPENVHVVATSPFSISISWSEPAVITGPT 1569
Y +V A T+ G G S+ I KT G P G P N+ A S SI++SWS P +
Sbjct: 488 YTVRVLAFTSVGDGPLSDPIQVKTQQGVP-GQPMNLRAEARSETSITLSWSPPRQESIIK 546
Query: 1570 CYLIDVKSVDNDEFNISFIKSNEENKTIEIKDLEIFTRYSVVITAFTGNISAAYVEGKSS 1629
L+ + E +F + + ++DL+ T Y+ ++A +G +
Sbjct: 547 YELLFREGDHGREVGRTF----DPTTSYVVEDLKPNTEYAF-------RLAARSPQGLGA 595
Query: 1630 AEMIVT--TLESAPKDPPNNMTFQKIPDEVTKFQLTFLPPSQPNGNIQVYQALVYREDDP 1687
+V TL+S P N + I T L++ P Y P
Sbjct: 596 FTPVVRQRTLQSIS---PKNFKVKMIMK--TSVLLSWEFPDN------------YNSPTP 638
Query: 1688 TAVQIHNLSIIQKTNTFVIAMLEGLKGGHTYN-ISVYAVNSAGAGPKVPMRITMDIKAPA 1746
+Q + L++ T ++ LK YN + +S G + T
Sbjct: 639 YKIQYNGLTLDVDGRT-TKKLITHLKPHTFYNFVLTNRGSSLGGLQQTVTAWTAFNLLNG 697
Query: 1747 RPKTKPTPIYDATGKLLVTSTTITIRMPICYYSDDHGPIKNVQ--VLVTETGAQHDGNVT 1804
+P P P DA G ++V +P+ Y P++ + +T G+ D ++
Sbjct: 698 KPSVAPKP--DADGFIMVYLPDGQSPVPVQSYFIVMVPLRKSRGGQFLTPLGSPEDMDLE 755
Query: 1805 KW-------------YDAYFNKARPYFTNEGFPNPPCTEGKTKFSGNEEIYIIGADNACM 1851
+ + RPY PP T G+++ Y G DN +
Sbjct: 756 ELIQDISRLQRRSLRHSRQLEVPRPYIAARFSVLPP-----TFHPGDQKQYG-GFDNRGL 809
Query: 1852 IPGNEDKICNGPLKPKKQYLFKFRATNIMGQFTDSDYSDPVKTLGEGLSERTVEIILSVT 1911
PG+ + + K + F + Q + D P+ EGL ++
Sbjct: 810 EPGHRYVLFVLAVLQKSEPTFAASPFSDPFQLDNPD-PQPIVDGEEGLIW-----VIGPV 863
Query: 1912 LCILSIILLGTAIFAFARIRQKQKEGGTYSPQDAEIIDTKLKLDQLITVADL---ELKDE 1968
L ++ II + AI + + D++ D++ + L+ ADL KD
Sbjct: 864 LAVVFIICIVIAILLYK------------NKPDSKRKDSEPRTKCLLNNADLAPHHPKDP 911
Query: 1969 RLTRLLSYRK----SIKPISKKSFLQHVEELCTNNNLKFQEEFSELPKFLQDLSSTDADL 2024
R ++++ S PI +H E L N++LK +E+ + Q + ++L
Sbjct: 912 VEMRRINFQTPGMLSHPPIPIADMAEHTERLKANDSLKLSQEYESIDPG-QQFTWEHSNL 970
Query: 2025 PWNRAKNRFPNIKPYNNNRVKLIADASVPGSDYINASYISGYLCPNEFIATQGPLPGTVG 2084
N+ KNR+ N+ Y+++RV L + GSDYINA+Y+ GY C N +IATQGPLP T G
Sbjct: 971 EVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFG 1030
Query: 2085 DFWRMVWETRAKTLVMLTQCFEKGRIRCHQYWPEDNKPVTVFGDIVITKLMEDVQIDWTI 2144
DFWRMVWE R+ T+VM+T+ EK RI+C QYWP N+ +G I +T L + +
Sbjct: 1031 DFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWP--NRGTETYGFIQVTLLDTIELATFCV 1088
Query: 2145 RDLKIERHG--DCMTVRQCNFTAWPEHGVPENSAPLIHFVKLVRASRAHDTTPMIVHCSA 2202
R + ++G + VRQ FTAWP+HGVPE P + F++ V+ D P++VHCSA
Sbjct: 1089 RTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSA 1148
Query: 2203 GVGRTGVFIALDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLLSN 2262
GVGRTG FI +D + + I VD+YG V +RS+R MVQ QY F+H+ +L+ +
Sbjct: 1149 GVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGC 1208
Query: 2263 KGSNQPICFVNYSALQKMDSLDAMEGDVELEWE 2295
+ P + Y+ +QK+ ++ E +E E
Sbjct: 1209 GNTEVPARSL-YAYIQKLAQVEPGEHVTGMELE 1240
Score = 191 bits (486), Expect = 5e-48
Identities = 106/245 (43%), Positives = 140/245 (57%), Gaps = 6/245 (2%)
Query: 2022 ADLPWNRAKNRFPNIKPYNNNRVKLIADASVPGSDYINASYISGYLCPNEFIATQGPLPG 2081
A+LP N+ KNR NI PY + RV L V GSDYINAS+I GY +IATQGPL
Sbjct: 1257 ANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAE 1316
Query: 2082 TVGDFWRMVWETRAKTLVMLTQCFEKGRIRCHQYWPEDNKPVTVFGDIVITKLMEDVQID 2141
T DFWRM+WE + +VMLT+ E GR +CHQYWP + + V+ + E
Sbjct: 1317 TTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERS--ARYQYFVVDPMAEYNMPQ 1374
Query: 2142 WTIRDLKI--ERHGDCMTVRQCNFTAWPEHGVPENSAPLIHFVKLVRASRAH--DTTPMI 2197
+ +R+ K+ R G TVRQ FT WPE GVP++ I F+ V ++ P+
Sbjct: 1375 YILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPIS 1434
Query: 2198 VHCSAGVGRTGVFIALDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCIL 2257
VHCSAGVGRTGVFI L + + + VDI+ V LR++R MVQ +Y F +Q L
Sbjct: 1435 VHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAAL 1494
Query: 2258 DLLSN 2262
+ L +
Sbjct: 1495 EYLGS 1499
Score = 92.8 bits (229), Expect = 3e-18
Identities = 103/421 (24%), Positives = 173/421 (41%), Gaps = 47/421 (11%)
Query: 1139 AQLYIKTEEDVPETSPIINTFKNLSSTSVLLSWDP--PVKPNGAIISYDLTLQ-GPNENY 1195
AQ+ +K+ P T + ++TS+ ++WD P + +I Y Q GP +
Sbjct: 315 AQITVKSLPKAPGTPMVTEN----TATSITITWDSGNPDPVSYYVIEYKSKSQDGPYQIK 370
Query: 1196 SFITSDNYIILEELSPFTLYSFFAAARTRKGLGP-SSILFFYTDESVPLAPPQNLTLINC 1254
IT+ Y I LSP + Y + +A G GP S + T E P + P+N+
Sbjct: 371 EDITTTRYSI-GGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARML 429
Query: 1255 TSDFVWLKWSPSPLPGGIVK---VYSFKIHEHETDTIYYKNI--SGFKTEAKLVGLEPVS 1309
++ + ++W P G+++ VY EH N+ S T L+ E
Sbjct: 430 SATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDE--- 486
Query: 1310 TYSIRVSAFTKVGNGNQFSNVVKFTTQESVPDVVQNMQCMATSWQSVLVKWDPPKKANGI 1369
TY++RV AFT VG+G S+ ++ TQ+ VP N++ A S S+ + W PP++ + I
Sbjct: 487 TYTVRVLAFTSVGDG-PLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPRQESII 545
Query: 1370 ITQYMVTVERNSTKVS---PQDHMYTFIKLLANTSYVFKVRASTSAGEGDESTCHVSTLP 1426
+ + + +V Y L NT Y F++ A + G G +
Sbjct: 546 KYELLFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPV---VRQ 602
Query: 1427 ETVPSV-PTNIAFSDVQSTSATLTWIRPDTILGYFQNYKITTQLRAQKCKEWESEECVEY 1485
T+ S+ P N + TS L+W PD NY T + ++Y
Sbjct: 603 RTLQSISPKNFKVKMIMKTSVLLSWEFPD-------NYNSPTPYK------------IQY 643
Query: 1486 QKIQYLYEAHLTEETVYGLKKFRWYRFQV---AASTNAGYGNASNWISTKTLPGPPDGPP 1542
+ + T++ + LK +Y F + +S + W + L G P P
Sbjct: 644 NGLTLDVDGRTTKKLITHLKPHTFYNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSVAP 703
Query: 1543 E 1543
+
Sbjct: 704 K 704
Score = 92.4 bits (228), Expect = 4e-18
Identities = 101/370 (27%), Positives = 153/370 (41%), Gaps = 40/370 (10%)
Query: 798 KRSNGNEERTINTTSLTQNIKVLKKYTQYIIEVSASTLKGEGVRSAPISILTEEDAPDSP 857
K +G + + T+ +I L ++Y I VSA G+G S + T E AP S
Sbjct: 361 KSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASA 420
Query: 858 PQDFSVKQLSGVTVKLSWQPPLEPNGIILYYTVYV----------WNRSSLKTINVTETS 907
P++ + LS T+ + W+ P+EPNG+I Y VY W + ++ +T
Sbjct: 421 PRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVG 480
Query: 908 LELSDLDYNVEYSAYVTASTRFGDGKTRSNIISFQTPEGAPSDPPKDVYYANLSSSSIIL 967
L D Y V V A T GDG S+ I +T +G P P ++ S +SI L
Sbjct: 481 SLLEDETYTVR----VLAFTSVGDGPL-SDPIQVKTQQGVPGQ-PMNLRAEARSETSITL 534
Query: 968 FWTPPSKPNGIIQYYSVYYRNTSGTFMQNFTLHEVTNDFDNMTVSTIIDKLTIFSYYTFW 1027
W+PP + II+Y ++ G EV FD T S +++ L + Y F
Sbjct: 535 SWSPP-RQESIIKYELLFREGDHG--------REVGRTFD-PTTSYVVEDLKPNTEYAFR 584
Query: 1028 LTASTSVGNGNKSSDIIEVYTDQDIPEGFVGNLTYESISSTAINVSWVPPAQPNGLVFY- 1086
L A + G G + ++ T Q I N + I T++ +SW P N Y
Sbjct: 585 LAARSPQGLG-AFTPVVRQRTLQSISP---KNFKVKMIMKTSVLLSWEFPDNYNSPTPYK 640
Query: 1087 --YVSLILQQTPRHVRPPLVTYERSIYFDNLEKYTDYILKITPSTEKGFSDTYTAQLYIK 1144
Y L L R + L+T+ + F N ++L S+ G T TA
Sbjct: 641 IQYNGLTLDVDGRTTK-KLITHLKPHTFYN------FVLTNRGSSLGGLQQTVTAWTAFN 693
Query: 1145 TEEDVPETSP 1154
P +P
Sbjct: 694 LLNGKPSVAP 703
Score = 92.0 bits (227), Expect = 6e-18
Identities = 101/416 (24%), Positives = 183/416 (43%), Gaps = 33/416 (7%)
Query: 581 SSSSILLYWDPPEYPNGKITHYTIYAMELDTNRAFQITT--IDNSFLITGLKKYTKYKMR 638
+++SI + WD +++Y I + +QI + I GL ++Y++
Sbjct: 335 TATSITITWDSGN--PDPVSYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIW 392
Query: 639 VAASTHVGESSLSEENDIFVRTSEDEPESSPQDVEVIDVTADEIRLKWSPPEKPNGIIIA 698
V+A +G+ SE + RT E P S+P++V+ ++A + ++W P +PNG+I
Sbjct: 393 VSAVNSIGQGPPSES--VVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRG 450
Query: 699 YEVLYKNIDTLYMKNTSTTDI------ILRNLRPHTLYNISVRSYTRFGHGNQVSSLLSV 752
Y V Y + N ++ + +L Y + V ++T G G +S + V
Sbjct: 451 YRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVGDG-PLSDPIQV 509
Query: 753 RTSETVPDSAPENITYKNISSGEIELSFLPPSSPNGIIQKYTIYLKRSNGNEE--RTINT 810
+T + VP P N+ + S I LS+ PP + I KY + + + E RT +
Sbjct: 510 KTQQGVP-GQPMNLRAEARSETSITLSWSPPRQES--IIKYELLFREGDHGREVGRTFDP 566
Query: 811 TSLTQNIKVLKKYTQYIIEVSASTLKGEGVRSAPISILTEEDAPDSPPQDFSVKQLSGVT 870
T+ + ++ LK T+Y ++A + +G G A ++ + P++F VK + +
Sbjct: 567 TT-SYVVEDLKPNTEYAFRLAARSPQGLG---AFTPVVRQRTLQSISPKNFKVKMIMKTS 622
Query: 871 VKLSWQPPLEPNGIILYYTVYVWNRSSLKTINVTETSLELSDLDYNVEYSAYVT--ASTR 928
V LSW+ P N Y Y N +L T L ++ L + Y+ +T S+
Sbjct: 623 VLLSWEFPDNYNSPTPYKIQY--NGLTLDVDGRTTKKL-ITHLKPHTFYNFVLTNRGSSL 679
Query: 929 FGDGKTRSNIISFQTPEGAPSDPPKDVYYANLSSSSIILFWTPPSKPNGIIQYYSV 984
G +T + +F G PS PK + I+ + P + +Q Y +
Sbjct: 680 GGLQQTVTAWTAFNLLNGKPSVAPKP------DADGFIMVYLPDGQSPVPVQSYFI 729
Score = 90.9 bits (224), Expect = 1e-17
Identities = 80/266 (30%), Positives = 133/266 (50%), Gaps = 18/266 (6%)
Query: 531 YVIRRLVPFTEHMISVSAFTIMGEGPPTVLSV-RTRQQVPSSI-KIINYKNISSSSILLY 588
Y I L P +E+ I VSA +G+GPP+ V RT +Q P+S + + + +S++++++
Sbjct: 378 YSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQ 437
Query: 589 WDPPEYPNGKITHYTI-YAMELDTNRA-FQITTIDNSFLIT--GLKKYTKYKMRVAASTH 644
W+ P PNG I Y + Y ME + +Q +D+S L T L + Y +RV A T
Sbjct: 438 WEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTS 497
Query: 645 VGESSLSEENDIFVRTSEDEPESSPQDVEVIDVTADEIRLKWSPPEKPNGIIIAYEVLYK 704
VG+ LS+ I V+T + P P ++ + I L WSPP + + II YE+L++
Sbjct: 498 VGDGPLSD--PIQVKTQQGVP-GQPMNLRAEARSETSITLSWSPPRQES--IIKYELLFR 552
Query: 705 NID---TLYMKNTSTTDIILRNLRPHTLYNISVRSYTRFGHGNQVSSLLSVRTSETVPDS 761
D + TT ++ +L+P+T Y + + + G G + V T+
Sbjct: 553 EGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLG----AFTPVVRQRTLQSI 608
Query: 762 APENITYKNISSGEIELSFLPPSSPN 787
+P+N K I + LS+ P + N
Sbjct: 609 SPKNFKVKMIMKTSVLLSWEFPDNYN 634
Score = 84.0 bits (206), Expect = 2e-15
Identities = 76/318 (23%), Positives = 134/318 (42%), Gaps = 44/318 (13%)
Query: 17 TQVDVSNVVPGTRYDITISSISTTYTSPVTRIVTTNVTKPGP---PVFLAGERVGSAGIL 73
T+ + + P + Y+I +S++++ P + V T + P P + + + ++
Sbjct: 376 TRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMI 435
Query: 74 LSWNTPPNPNGRIISYIVKYKEVCPWMQTVYTQVRSKPDSLEVLLTNLNPGTTYEIKVAA 133
+ W P PNG I Y V Y + P Q + DSL + +L TY ++V A
Sbjct: 436 VQWEEPVEPNGLIRGYRVYYT-MEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLA 494
Query: 134 ENSAGIGVFSDPFLFQTAESAPGKVVNLTVEAYNASAVKLIWYLPRQPNGKITSFKISVK 193
S G G SDP +T + PG+ +NL EA + +++ L W PRQ + I +++ +
Sbjct: 495 FTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPRQES--IIKYELLFR 552
Query: 194 HARSGIVVKDVSIRVEDILTGKLPECNENSESFLWSTASPSPT-LGRVTPP--SRTTHSS 250
G V R D T + E + + + + A+ SP LG TP RT S
Sbjct: 553 EGDHGREVG----RTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSI 608
Query: 251 ST-------LTQNEISSVWKEPISF------------------------VVTHLRPYTTY 279
S + + + W+ P ++ ++THL+P+T Y
Sbjct: 609 SPKNFKVKMIMKTSVLLSWEFPDNYNSPTPYKIQYNGLTLDVDGRTTKKLITHLKPHTFY 668
Query: 280 LFEVSAATTEAGYIDSTI 297
F ++ + G + T+
Sbjct: 669 NFVLTNRGSSLGGLQQTV 686
Score = 70.1 bits (170), Expect = 2e-11
Identities = 93/384 (24%), Positives = 160/384 (41%), Gaps = 53/384 (13%)
Query: 286 ATTEAGYIDSTIVRTPESVPEGPPQNCVTGNITGKSFSILWD---PPTIVTGKFSYRVEL 342
A + G I++ T +S+P+ P VT N T S +I WD P + Y+ +
Sbjct: 304 AMSSLGVIEAVAQITVKSLPKAPGTPMVTEN-TATSITITWDSGNPDPVSYYVIEYKSKS 362
Query: 343 YGPSGRILDNSTKDLKFAFTNLTPFTMYDVYIAAETSAGTGPKS-NISVFTPPDVPG-AV 400
+I ++ T +++ L+P + Y+++++A S G GP S ++ T P A
Sbjct: 363 QDGPYQIKEDITTT-RYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAP 421
Query: 401 FDLQLAEVESTQVRITWKKPRQPNGIINQYRV-KVLVPETGI------ILENTLLTGNNE 453
++Q + +T + + W++P +PNG+I YRV + PE + ++++LLT
Sbjct: 422 RNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGS 481
Query: 454 YINDPMAPEIVNIVEPMVGLYEGSAEMSSDLHSLATFIYNSHPDKNFPARNRAEDQTSPV 513
+ D V + G +S + P + R A +TS
Sbjct: 482 LLEDE-----TYTVRVLAFTSVGDGPLSDPIQ---VKTQQGVPGQPMNLRAEARSETSIT 533
Query: 514 VTTRNQYITDIAAEQL-------------------SYVIRRLVPFTEHMISVSAFTIMGE 554
++ I +L SYV+ L P TE+ ++A + G
Sbjct: 534 LSWSPPRQESIIKYELLFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGL 593
Query: 555 GPPT-VLSVRTRQQV-PSSIKIINYKNISSSSILLYWDPPEYPNGKITHYTIY-AMELDT 611
G T V+ RT Q + P + K+ K I +S+LL W+ P+ N + Y + LD
Sbjct: 594 GAFTPVVRQRTLQSISPKNFKV---KMIMKTSVLLSWEFPDNYNSPTPYKIQYNGLTLDV 650
Query: 612 NRAFQITTIDNSFLITGLKKYTKY 635
+ LIT LK +T Y
Sbjct: 651 DGR------TTKKLITHLKPHTFY 668
Score = 65.1 bits (157), Expect = 8e-10
Identities = 73/288 (25%), Positives = 126/288 (43%), Gaps = 29/288 (10%)
Query: 527 EQLSYVIRRLVPFTEHMISVSAFTIMGEGP-PTVLSVRTRQQVPSSIKIINYKNISSSSI 585
+ L + L+ + + V AFT +G+GP + V+T+Q VP + + S +SI
Sbjct: 473 DSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSI 532
Query: 586 LLYWDPPEYPNGKITHYTIYAMELD----TNRAFQITTIDNSFLITGLKKYTKYKMRVAA 641
L W PP + I Y + E D R F TT S+++ LK T+Y R+AA
Sbjct: 533 TLSWSPPRQES--IIKYELLFREGDHGREVGRTFDPTT---SYVVEDLKPNTEYAFRLAA 587
Query: 642 STHVGESSLSEENDIFVRTSEDEPESSPQDVEVIDVTADEIRLKWSPPEKPNGIIIAYEV 701
+ G + + V SP++ +V + + L W P+ N Y++
Sbjct: 588 RSPQGLGAFTP-----VVRQRTLQSISPKNFKVKMIMKTSVLLSWEFPDNYNS-PTPYKI 641
Query: 702 LYKNIDTLYMKNTSTTDIILRNLRPHTLYNISVRSYTRFGHGNQVSSLLSVRTSETVPD- 760
Y + TL + + TT ++ +L+PHT YN + G+ + L T+ T +
Sbjct: 642 QYNGL-TLDV-DGRTTKKLITHLKPHTFYN-----FVLTNRGSSLGGLQQTVTAWTAFNL 694
Query: 761 -SAPENITYKNISSGEIELSFLPPSSPNGIIQKYTIY---LKRSNGNE 804
+ ++ K + G I + +LP +Q Y I L++S G +
Sbjct: 695 LNGKPSVAPKPDADGFI-MVYLPDGQSPVPVQSYFIVMVPLRKSRGGQ 741
Score = 63.2 bits (152), Expect = 3e-09
Identities = 82/390 (21%), Positives = 154/390 (39%), Gaps = 55/390 (14%)
Query: 45 VTRIVTTNVTK-PGPPVFLAGERVGSAGILLSWNTP-PNPNGRIISYIVKYKEVCPWMQT 102
V +I ++ K PG P+ + I ++W++ P+P + Y+++YK Q
Sbjct: 314 VAQITVKSLPKAPGTPMVTENT---ATSITITWDSGNPDP---VSYYVIEYKSKS---QD 364
Query: 103 VYTQVRSKPDSLEVLLTNLNPGTTYEIKVAAENSAGIGVFSDPFLFQTAESAPGKVV-NL 161
Q++ + + L+P + YEI V+A NS G G S+ + +T E AP N+
Sbjct: 365 GPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNV 424
Query: 162 TVEAYNASAVKLIWYLPRQPNGKITSFKISVKHARSGIVVKDVSIRVEDILTGKLPECNE 221
+A+ + + W P +PNG I +++ V V+D L + E
Sbjct: 425 QARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLE 484
Query: 222 NSESFLWSTASPSPTLGRVTPPSRT------------------THSSSTLTQN------- 256
+ + A S G ++ P + + +S TL+ +
Sbjct: 485 DETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPRQESI 544
Query: 257 --------------EISSVWKEPISFVVTHLRPYTTYLFEVSAATTEAGYIDSTIVRTPE 302
E+ + S+VV L+P T Y F ++A + + + +VR
Sbjct: 545 IKYELLFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVR-QR 603
Query: 303 SVPEGPPQNCVTGNITGKSFSILWDPPTIVTGKFSYRVELYGPSGRILDNSTKDLKFAFT 362
++ P+N I S + W+ P Y+++ +G LD + K T
Sbjct: 604 TLQSISPKNFKVKMIMKTSVLLSWEFPDNYNSPTPYKIQY---NGLTLDVDGRTTKKLIT 660
Query: 363 NLTPFTMYDVYIAAETSAGTGPKSNISVFT 392
+L P T Y+ + S+ G + ++ +T
Sbjct: 661 HLKPHTFYNFVLTNRGSSLGGLQQTVTAWT 690
Score = 62.0 bits (149), Expect = 7e-09
Identities = 74/311 (23%), Positives = 135/311 (43%), Gaps = 20/311 (6%)
Query: 1066 SSTAINVSWVPPAQPNGLVFYYVSLIL--QQTPRHVRPPLVTYERSIYFDNLEKYTDYIL 1123
++T+I ++W P+ + +Y + Q P ++ + T SI L ++Y +
Sbjct: 335 TATSITITW-DSGNPDPVSYYVIEYKSKSQDGPYQIKEDITTTRYSI--GGLSPNSEYEI 391
Query: 1124 KITPSTEKGFSDTYTAQLYIKTEEDVPETSPIINTFKNLSSTSVLLSWDPPVKPNGAI-- 1181
++ G + + +T E P ++P + LS+T++++ W+ PV+PNG I
Sbjct: 392 WVSAVNSIGQGPP-SESVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRG 450
Query: 1182 --ISYDLTLQGPNENYSFITSDNYII--LEELSPFTLYSFFAAARTRKGLGP-SSILFFY 1236
+ Y + + P N+ D+ ++ + L Y+ A T G GP S +
Sbjct: 451 YRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVK 510
Query: 1237 TDESVPLAPPQNLTLINCTSDFVWLKWSPSPLPGGIVKVYSFKIHEHETDTIYYKNISGF 1296
T + VP P NL + + L WSP P I+K Y E + +
Sbjct: 511 TQQGVP-GQPMNLRAEARSETSITLSWSP-PRQESIIK-YELLFREGDHGREVGRTFDP- 566
Query: 1297 KTEAKLVGLEPVSTYSIRVSAFTKVGNGNQFSNVVKFTTQESVPDVVQNMQCMATSWQSV 1356
T + L+P + Y+ R++A + G G F+ VV+ T +S+ +N + SV
Sbjct: 567 TTSYVVEDLKPNTEYAFRLAARSPQGLG-AFTPVVRQRTLQSISP--KNFKVKMIMKTSV 623
Query: 1357 LVKWDPPKKAN 1367
L+ W+ P N
Sbjct: 624 LLSWEFPDNYN 634
Score = 57.8 bits (138), Expect = 1e-07
Identities = 52/219 (23%), Positives = 86/219 (39%), Gaps = 14/219 (6%)
Query: 213 TGKLPECNENSESFLWSTASPSPTLGRVTPPSRTTHSSSTLTQNEISSVWKEPISFVVTH 272
T + E S + W + +P P V + + +I++ + +
Sbjct: 328 TPMVTENTATSITITWDSGNPDPVSYYVIEYKSKSQDGPYQIKEDITTT-----RYSIGG 382
Query: 273 LRPYTTYLFEVSAATT--EAGYIDSTIVRTPESVPEGPPQNCVTGNITGKSFSILWDPPT 330
L P + Y VSA + + +S + RT E P P+N ++ + + W+ P
Sbjct: 383 LSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPV 442
Query: 331 IVTG-----KFSYRVELYGPSGRILDNSTKD-LKFAFTNLTPFTMYDVYIAAETSAGTGP 384
G + Y +E P G ++ D L +L Y V + A TS G GP
Sbjct: 443 EPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVGDGP 502
Query: 385 KSN-ISVFTPPDVPGAVFDLQLAEVESTQVRITWKKPRQ 422
S+ I V T VPG +L+ T + ++W PRQ
Sbjct: 503 LSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPRQ 541
Score = 53.5 bits (127), Expect = 2e-06
Identities = 91/405 (22%), Positives = 159/405 (39%), Gaps = 52/405 (12%)
Query: 1335 TQESVPDVVQNMQCMATSWQSVLVKWDPPKKANGIITQYMVTVERNSTKVSPQDHMYTFI 1394
+ E +P N+ C+A VKW + A + + + V RN ++ T +
Sbjct: 244 SHEIMPGGNVNITCVAVGSPMPYVKW--MQGAEDLTPEDDMPVGRNVLEL-------TDV 294
Query: 1395 KLLANTSYVFKVRASTSAGEGDESTCHVSTLPETVPSVPTNIAFSDVQSTSATLTWI--R 1452
K AN + V A +S G E+ ++ +++P P ++ +TS T+TW
Sbjct: 295 KDSANYTCV----AMSSLGV-IEAVAQITV--KSLPKAPGTPMVTENTATSITITWDSGN 347
Query: 1453 PDTILGYFQNYKITTQLRAQKCKEWESEECVEYQKIQYLYEAHLTEETVYGLKKFRWYRF 1512
PD + Y YK +Q + KE + T ++ GL Y
Sbjct: 348 PDPVSYYVIEYKSKSQDGPYQIKE----------------DITTTRYSIGGLSPNSEYEI 391
Query: 1513 QVAASTNAGYGNASNWISTKTLPGPPDGPPENVHVVATSPFSISISWSEPAVITGPTCYL 1572
V+A + G G S + T+T P P NV S ++ + W EP G
Sbjct: 392 WVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGY 451
Query: 1573 IDVKSVDNDEFNISFIKSNEENKTI-EIKDLEIFTRYSVVITAFTGNISAAYVEGKSSAE 1631
+++ + ++ K N ++ + + L Y+V + AFT + +G S
Sbjct: 452 RVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFT-----SVGDGPLSDP 506
Query: 1632 MIVTTLESAPKDPPNNMTFQKIPDEVTKFQLTFLPPSQPNGNIQVYQALVYREDDPTAVQ 1691
+ V T + P P N + +T L++ PP Q +I Y+ L++RE D
Sbjct: 507 IQVKTQQGVPGQPMNLRAEARSETSIT---LSWSPPRQE--SIIKYE-LLFREGD----- 555
Query: 1692 IHNLSIIQKTNTFVIAMLEGLKGGHTYNISVYAVNSAGAGPKVPM 1736
H + + + ++E LK Y + A + G G P+
Sbjct: 556 -HGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPV 599
>gi|104487295 protein tyrosine phosphatase, receptor type, sigma
isoform 3 precursor [Homo sapiens]
Length = 1501
Score = 273 bits (697), Expect = 2e-72
Identities = 267/993 (26%), Positives = 431/993 (43%), Gaps = 102/993 (10%)
Query: 1335 TQESVPDVVQNMQCMATSWQSVLVKWDP--PKKANGIITQYMVTVERNSTKVSPQ--DHM 1390
T +S+P + S+ + WD P + + +Y + ++
Sbjct: 314 TVKSLPKAPGTPMVTENTATSITITWDSGNPDPVSYYVIEYKSKSQDGPYQIKEDITTTR 373
Query: 1391 YTFIKLLANTSYVFKVRASTSAGEGDESTCHVSTLPETVP-SVPTNIAFSDVQSTSATLT 1449
Y+ L N+ Y V A S G+G S V+ E P S P N+ + +T+ +
Sbjct: 374 YSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQ 433
Query: 1450 WIRPDTILGYFQNYKITTQLRAQKCKEWESEECVEYQKIQYLYEAHLTEETVYGLKKFRW 1509
W P G + Y++ + E E V + + ++ LT TV L +
Sbjct: 434 WEEPVEPNGLIRGYRVYYTM--------EPEHPVGNWQKHNVDDSLLT--TVGSLLEDET 483
Query: 1510 YRFQVAASTNAGYGNASNWISTKTLPGPPDGPPENVHVVATSPFSISISWSEPAVITGPT 1569
Y +V A T+ G G S+ I KT G P G P N+ A S SI++SWS P +
Sbjct: 484 YTVRVLAFTSVGDGPLSDPIQVKTQQGVP-GQPMNLRAEARSETSITLSWSPPRQESIIK 542
Query: 1570 CYLIDVKSVDNDEFNISFIKSNEENKTIEIKDLEIFTRYSVVITAFTGNISAAYVEGKSS 1629
L+ + E +F + + ++DL+ T Y+ ++A +G +
Sbjct: 543 YELLFREGDHGREVGRTF----DPTTSYVVEDLKPNTEYAF-------RLAARSPQGLGA 591
Query: 1630 AEMIVT--TLESAPKDPPNNMTFQKIPDEVTKFQLTFLPPSQPNGNIQVYQALVYREDDP 1687
+V TL+S P N + I T L++ P Y P
Sbjct: 592 FTPVVRQRTLQSIS---PKNFKVKMIMK--TSVLLSWEFPDN------------YNSPTP 634
Query: 1688 TAVQIHNLSIIQKTNTFVIAMLEGLKGGHTYN-ISVYAVNSAGAGPKVPMRITMDIKAPA 1746
+Q + L++ T ++ LK YN + +S G + T
Sbjct: 635 YKIQYNGLTLDVDGRT-TKKLITHLKPHTFYNFVLTNRGSSLGGLQQTVTAWTAFNLLNG 693
Query: 1747 RPKTKPTPIYDATGKLLVTSTTITIRMPICYYSDDHGPIKNVQ--VLVTETGAQHDGNVT 1804
+P P P DA G ++V +P+ Y P++ + +T G+ D ++
Sbjct: 694 KPSVAPKP--DADGFIMVYLPDGQSPVPVQSYFIVMVPLRKSRGGQFLTPLGSPEDMDLE 751
Query: 1805 KW-------------YDAYFNKARPYFTNEGFPNPPCTEGKTKFSGNEEIYIIGADNACM 1851
+ + RPY PP T G+++ Y G DN +
Sbjct: 752 ELIQDISRLQRRSLRHSRQLEVPRPYIAARFSVLPP-----TFHPGDQKQYG-GFDNRGL 805
Query: 1852 IPGNEDKICNGPLKPKKQYLFKFRATNIMGQFTDSDYSDPVKTLGEGLSERTVEIILSVT 1911
PG+ + + K + F + Q + D P+ EGL ++
Sbjct: 806 EPGHRYVLFVLAVLQKSEPTFAASPFSDPFQLDNPD-PQPIVDGEEGLIW-----VIGPV 859
Query: 1912 LCILSIILLGTAIFAFARIRQKQKEGGTYSPQDAEIIDTKLKLDQLITVADL---ELKDE 1968
L ++ II + AI + + D++ D++ + L+ ADL KD
Sbjct: 860 LAVVFIICIVIAILLYK------------NKPDSKRKDSEPRTKCLLNNADLAPHHPKDP 907
Query: 1969 RLTRLLSYRK----SIKPISKKSFLQHVEELCTNNNLKFQEEFSELPKFLQDLSSTDADL 2024
R ++++ S PI +H E L N++LK +E+ + Q + ++L
Sbjct: 908 VEMRRINFQTPGMLSHPPIPIADMAEHTERLKANDSLKLSQEYESIDPG-QQFTWEHSNL 966
Query: 2025 PWNRAKNRFPNIKPYNNNRVKLIADASVPGSDYINASYISGYLCPNEFIATQGPLPGTVG 2084
N+ KNR+ N+ Y+++RV L + GSDYINA+Y+ GY C N +IATQGPLP T G
Sbjct: 967 EVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFG 1026
Query: 2085 DFWRMVWETRAKTLVMLTQCFEKGRIRCHQYWPEDNKPVTVFGDIVITKLMEDVQIDWTI 2144
DFWRMVWE R+ T+VM+T+ EK RI+C QYWP N+ +G I +T L + +
Sbjct: 1027 DFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWP--NRGTETYGFIQVTLLDTIELATFCV 1084
Query: 2145 RDLKIERHG--DCMTVRQCNFTAWPEHGVPENSAPLIHFVKLVRASRAHDTTPMIVHCSA 2202
R + ++G + VRQ FTAWP+HGVPE P + F++ V+ D P++VHCSA
Sbjct: 1085 RTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSA 1144
Query: 2203 GVGRTGVFIALDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLLSN 2262
GVGRTG FI +D + + I VD+YG V +RS+R MVQ QY F+H+ +L+ +
Sbjct: 1145 GVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGC 1204
Query: 2263 KGSNQPICFVNYSALQKMDSLDAMEGDVELEWE 2295
+ P + Y+ +QK+ ++ E +E E
Sbjct: 1205 GNTEVPARSL-YAYIQKLAQVEPGEHVTGMELE 1236
Score = 191 bits (486), Expect = 5e-48
Identities = 106/245 (43%), Positives = 140/245 (57%), Gaps = 6/245 (2%)
Query: 2022 ADLPWNRAKNRFPNIKPYNNNRVKLIADASVPGSDYINASYISGYLCPNEFIATQGPLPG 2081
A+LP N+ KNR NI PY + RV L V GSDYINAS+I GY +IATQGPL
Sbjct: 1253 ANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAE 1312
Query: 2082 TVGDFWRMVWETRAKTLVMLTQCFEKGRIRCHQYWPEDNKPVTVFGDIVITKLMEDVQID 2141
T DFWRM+WE + +VMLT+ E GR +CHQYWP + + V+ + E
Sbjct: 1313 TTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERS--ARYQYFVVDPMAEYNMPQ 1370
Query: 2142 WTIRDLKI--ERHGDCMTVRQCNFTAWPEHGVPENSAPLIHFVKLVRASRAH--DTTPMI 2197
+ +R+ K+ R G TVRQ FT WPE GVP++ I F+ V ++ P+
Sbjct: 1371 YILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPIS 1430
Query: 2198 VHCSAGVGRTGVFIALDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCIL 2257
VHCSAGVGRTGVFI L + + + VDI+ V LR++R MVQ +Y F +Q L
Sbjct: 1431 VHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAAL 1490
Query: 2258 DLLSN 2262
+ L +
Sbjct: 1491 EYLGS 1495
Score = 92.8 bits (229), Expect = 3e-18
Identities = 103/421 (24%), Positives = 173/421 (41%), Gaps = 47/421 (11%)
Query: 1139 AQLYIKTEEDVPETSPIINTFKNLSSTSVLLSWDP--PVKPNGAIISYDLTLQ-GPNENY 1195
AQ+ +K+ P T + ++TS+ ++WD P + +I Y Q GP +
Sbjct: 311 AQITVKSLPKAPGTPMVTEN----TATSITITWDSGNPDPVSYYVIEYKSKSQDGPYQIK 366
Query: 1196 SFITSDNYIILEELSPFTLYSFFAAARTRKGLGP-SSILFFYTDESVPLAPPQNLTLINC 1254
IT+ Y I LSP + Y + +A G GP S + T E P + P+N+
Sbjct: 367 EDITTTRYSI-GGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARML 425
Query: 1255 TSDFVWLKWSPSPLPGGIVK---VYSFKIHEHETDTIYYKNI--SGFKTEAKLVGLEPVS 1309
++ + ++W P G+++ VY EH N+ S T L+ E
Sbjct: 426 SATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDE--- 482
Query: 1310 TYSIRVSAFTKVGNGNQFSNVVKFTTQESVPDVVQNMQCMATSWQSVLVKWDPPKKANGI 1369
TY++RV AFT VG+G S+ ++ TQ+ VP N++ A S S+ + W PP++ + I
Sbjct: 483 TYTVRVLAFTSVGDG-PLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPRQESII 541
Query: 1370 ITQYMVTVERNSTKVS---PQDHMYTFIKLLANTSYVFKVRASTSAGEGDESTCHVSTLP 1426
+ + + +V Y L NT Y F++ A + G G +
Sbjct: 542 KYELLFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPV---VRQ 598
Query: 1427 ETVPSV-PTNIAFSDVQSTSATLTWIRPDTILGYFQNYKITTQLRAQKCKEWESEECVEY 1485
T+ S+ P N + TS L+W PD NY T + ++Y
Sbjct: 599 RTLQSISPKNFKVKMIMKTSVLLSWEFPD-------NYNSPTPYK------------IQY 639
Query: 1486 QKIQYLYEAHLTEETVYGLKKFRWYRFQV---AASTNAGYGNASNWISTKTLPGPPDGPP 1542
+ + T++ + LK +Y F + +S + W + L G P P
Sbjct: 640 NGLTLDVDGRTTKKLITHLKPHTFYNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSVAP 699
Query: 1543 E 1543
+
Sbjct: 700 K 700
Score = 92.4 bits (228), Expect = 4e-18
Identities = 101/370 (27%), Positives = 153/370 (41%), Gaps = 40/370 (10%)
Query: 798 KRSNGNEERTINTTSLTQNIKVLKKYTQYIIEVSASTLKGEGVRSAPISILTEEDAPDSP 857
K +G + + T+ +I L ++Y I VSA G+G S + T E AP S
Sbjct: 357 KSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASA 416
Query: 858 PQDFSVKQLSGVTVKLSWQPPLEPNGIILYYTVYV----------WNRSSLKTINVTETS 907
P++ + LS T+ + W+ P+EPNG+I Y VY W + ++ +T
Sbjct: 417 PRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVG 476
Query: 908 LELSDLDYNVEYSAYVTASTRFGDGKTRSNIISFQTPEGAPSDPPKDVYYANLSSSSIIL 967
L D Y V V A T GDG S+ I +T +G P P ++ S +SI L
Sbjct: 477 SLLEDETYTVR----VLAFTSVGDGPL-SDPIQVKTQQGVPGQ-PMNLRAEARSETSITL 530
Query: 968 FWTPPSKPNGIIQYYSVYYRNTSGTFMQNFTLHEVTNDFDNMTVSTIIDKLTIFSYYTFW 1027
W+PP + II+Y ++ G EV FD T S +++ L + Y F
Sbjct: 531 SWSPP-RQESIIKYELLFREGDHG--------REVGRTFD-PTTSYVVEDLKPNTEYAFR 580
Query: 1028 LTASTSVGNGNKSSDIIEVYTDQDIPEGFVGNLTYESISSTAINVSWVPPAQPNGLVFY- 1086
L A + G G + ++ T Q I N + I T++ +SW P N Y
Sbjct: 581 LAARSPQGLG-AFTPVVRQRTLQSISP---KNFKVKMIMKTSVLLSWEFPDNYNSPTPYK 636
Query: 1087 --YVSLILQQTPRHVRPPLVTYERSIYFDNLEKYTDYILKITPSTEKGFSDTYTAQLYIK 1144
Y L L R + L+T+ + F N ++L S+ G T TA
Sbjct: 637 IQYNGLTLDVDGRTTK-KLITHLKPHTFYN------FVLTNRGSSLGGLQQTVTAWTAFN 689
Query: 1145 TEEDVPETSP 1154
P +P
Sbjct: 690 LLNGKPSVAP 699
Score = 92.0 bits (227), Expect = 6e-18
Identities = 101/416 (24%), Positives = 183/416 (43%), Gaps = 33/416 (7%)
Query: 581 SSSSILLYWDPPEYPNGKITHYTIYAMELDTNRAFQITT--IDNSFLITGLKKYTKYKMR 638
+++SI + WD +++Y I + +QI + I GL ++Y++
Sbjct: 331 TATSITITWDSGN--PDPVSYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIW 388
Query: 639 VAASTHVGESSLSEENDIFVRTSEDEPESSPQDVEVIDVTADEIRLKWSPPEKPNGIIIA 698
V+A +G+ SE + RT E P S+P++V+ ++A + ++W P +PNG+I
Sbjct: 389 VSAVNSIGQGPPSES--VVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRG 446
Query: 699 YEVLYKNIDTLYMKNTSTTDI------ILRNLRPHTLYNISVRSYTRFGHGNQVSSLLSV 752
Y V Y + N ++ + +L Y + V ++T G G +S + V
Sbjct: 447 YRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVGDG-PLSDPIQV 505
Query: 753 RTSETVPDSAPENITYKNISSGEIELSFLPPSSPNGIIQKYTIYLKRSNGNEE--RTINT 810
+T + VP P N+ + S I LS+ PP + I KY + + + E RT +
Sbjct: 506 KTQQGVP-GQPMNLRAEARSETSITLSWSPPRQES--IIKYELLFREGDHGREVGRTFDP 562
Query: 811 TSLTQNIKVLKKYTQYIIEVSASTLKGEGVRSAPISILTEEDAPDSPPQDFSVKQLSGVT 870
T+ + ++ LK T+Y ++A + +G G A ++ + P++F VK + +
Sbjct: 563 TT-SYVVEDLKPNTEYAFRLAARSPQGLG---AFTPVVRQRTLQSISPKNFKVKMIMKTS 618
Query: 871 VKLSWQPPLEPNGIILYYTVYVWNRSSLKTINVTETSLELSDLDYNVEYSAYVT--ASTR 928
V LSW+ P N Y Y N +L T L ++ L + Y+ +T S+
Sbjct: 619 VLLSWEFPDNYNSPTPYKIQY--NGLTLDVDGRTTKKL-ITHLKPHTFYNFVLTNRGSSL 675
Query: 929 FGDGKTRSNIISFQTPEGAPSDPPKDVYYANLSSSSIILFWTPPSKPNGIIQYYSV 984
G +T + +F G PS PK + I+ + P + +Q Y +
Sbjct: 676 GGLQQTVTAWTAFNLLNGKPSVAPKP------DADGFIMVYLPDGQSPVPVQSYFI 725
Score = 90.9 bits (224), Expect = 1e-17
Identities = 80/266 (30%), Positives = 133/266 (50%), Gaps = 18/266 (6%)
Query: 531 YVIRRLVPFTEHMISVSAFTIMGEGPPTVLSV-RTRQQVPSSI-KIINYKNISSSSILLY 588
Y I L P +E+ I VSA +G+GPP+ V RT +Q P+S + + + +S++++++
Sbjct: 374 YSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQ 433
Query: 589 WDPPEYPNGKITHYTI-YAMELDTNRA-FQITTIDNSFLIT--GLKKYTKYKMRVAASTH 644
W+ P PNG I Y + Y ME + +Q +D+S L T L + Y +RV A T
Sbjct: 434 WEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTS 493
Query: 645 VGESSLSEENDIFVRTSEDEPESSPQDVEVIDVTADEIRLKWSPPEKPNGIIIAYEVLYK 704
VG+ LS+ I V+T + P P ++ + I L WSPP + + II YE+L++
Sbjct: 494 VGDGPLSD--PIQVKTQQGVP-GQPMNLRAEARSETSITLSWSPPRQES--IIKYELLFR 548
Query: 705 NID---TLYMKNTSTTDIILRNLRPHTLYNISVRSYTRFGHGNQVSSLLSVRTSETVPDS 761
D + TT ++ +L+P+T Y + + + G G + V T+
Sbjct: 549 EGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLG----AFTPVVRQRTLQSI 604
Query: 762 APENITYKNISSGEIELSFLPPSSPN 787
+P+N K I + LS+ P + N
Sbjct: 605 SPKNFKVKMIMKTSVLLSWEFPDNYN 630
Score = 84.0 bits (206), Expect = 2e-15
Identities = 76/318 (23%), Positives = 134/318 (42%), Gaps = 44/318 (13%)
Query: 17 TQVDVSNVVPGTRYDITISSISTTYTSPVTRIVTTNVTKPGP---PVFLAGERVGSAGIL 73
T+ + + P + Y+I +S++++ P + V T + P P + + + ++
Sbjct: 372 TRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMI 431
Query: 74 LSWNTPPNPNGRIISYIVKYKEVCPWMQTVYTQVRSKPDSLEVLLTNLNPGTTYEIKVAA 133
+ W P PNG I Y V Y + P Q + DSL + +L TY ++V A
Sbjct: 432 VQWEEPVEPNGLIRGYRVYYT-MEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLA 490
Query: 134 ENSAGIGVFSDPFLFQTAESAPGKVVNLTVEAYNASAVKLIWYLPRQPNGKITSFKISVK 193
S G G SDP +T + PG+ +NL EA + +++ L W PRQ + I +++ +
Sbjct: 491 FTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPRQES--IIKYELLFR 548
Query: 194 HARSGIVVKDVSIRVEDILTGKLPECNENSESFLWSTASPSPT-LGRVTPP--SRTTHSS 250
G V R D T + E + + + + A+ SP LG TP RT S
Sbjct: 549 EGDHGREVG----RTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSI 604
Query: 251 ST-------LTQNEISSVWKEPISF------------------------VVTHLRPYTTY 279
S + + + W+ P ++ ++THL+P+T Y
Sbjct: 605 SPKNFKVKMIMKTSVLLSWEFPDNYNSPTPYKIQYNGLTLDVDGRTTKKLITHLKPHTFY 664
Query: 280 LFEVSAATTEAGYIDSTI 297
F ++ + G + T+
Sbjct: 665 NFVLTNRGSSLGGLQQTV 682
Score = 70.1 bits (170), Expect = 2e-11
Identities = 93/384 (24%), Positives = 160/384 (41%), Gaps = 53/384 (13%)
Query: 286 ATTEAGYIDSTIVRTPESVPEGPPQNCVTGNITGKSFSILWD---PPTIVTGKFSYRVEL 342
A + G I++ T +S+P+ P VT N T S +I WD P + Y+ +
Sbjct: 300 AMSSLGVIEAVAQITVKSLPKAPGTPMVTEN-TATSITITWDSGNPDPVSYYVIEYKSKS 358
Query: 343 YGPSGRILDNSTKDLKFAFTNLTPFTMYDVYIAAETSAGTGPKS-NISVFTPPDVPG-AV 400
+I ++ T +++ L+P + Y+++++A S G GP S ++ T P A
Sbjct: 359 QDGPYQIKEDITTT-RYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAP 417
Query: 401 FDLQLAEVESTQVRITWKKPRQPNGIINQYRV-KVLVPETGI------ILENTLLTGNNE 453
++Q + +T + + W++P +PNG+I YRV + PE + ++++LLT
Sbjct: 418 RNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGS 477
Query: 454 YINDPMAPEIVNIVEPMVGLYEGSAEMSSDLHSLATFIYNSHPDKNFPARNRAEDQTSPV 513
+ D V + G +S + P + R A +TS
Sbjct: 478 LLEDE-----TYTVRVLAFTSVGDGPLSDPIQ---VKTQQGVPGQPMNLRAEARSETSIT 529
Query: 514 VTTRNQYITDIAAEQL-------------------SYVIRRLVPFTEHMISVSAFTIMGE 554
++ I +L SYV+ L P TE+ ++A + G
Sbjct: 530 LSWSPPRQESIIKYELLFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGL 589
Query: 555 GPPT-VLSVRTRQQV-PSSIKIINYKNISSSSILLYWDPPEYPNGKITHYTIY-AMELDT 611
G T V+ RT Q + P + K+ K I +S+LL W+ P+ N + Y + LD
Sbjct: 590 GAFTPVVRQRTLQSISPKNFKV---KMIMKTSVLLSWEFPDNYNSPTPYKIQYNGLTLDV 646
Query: 612 NRAFQITTIDNSFLITGLKKYTKY 635
+ LIT LK +T Y
Sbjct: 647 DGR------TTKKLITHLKPHTFY 664
Score = 65.1 bits (157), Expect = 8e-10
Identities = 73/288 (25%), Positives = 126/288 (43%), Gaps = 29/288 (10%)
Query: 527 EQLSYVIRRLVPFTEHMISVSAFTIMGEGP-PTVLSVRTRQQVPSSIKIINYKNISSSSI 585
+ L + L+ + + V AFT +G+GP + V+T+Q VP + + S +SI
Sbjct: 469 DSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSI 528
Query: 586 LLYWDPPEYPNGKITHYTIYAMELD----TNRAFQITTIDNSFLITGLKKYTKYKMRVAA 641
L W PP + I Y + E D R F TT S+++ LK T+Y R+AA
Sbjct: 529 TLSWSPPRQES--IIKYELLFREGDHGREVGRTFDPTT---SYVVEDLKPNTEYAFRLAA 583
Query: 642 STHVGESSLSEENDIFVRTSEDEPESSPQDVEVIDVTADEIRLKWSPPEKPNGIIIAYEV 701
+ G + + V SP++ +V + + L W P+ N Y++
Sbjct: 584 RSPQGLGAFTP-----VVRQRTLQSISPKNFKVKMIMKTSVLLSWEFPDNYNS-PTPYKI 637
Query: 702 LYKNIDTLYMKNTSTTDIILRNLRPHTLYNISVRSYTRFGHGNQVSSLLSVRTSETVPD- 760
Y + TL + + TT ++ +L+PHT YN + G+ + L T+ T +
Sbjct: 638 QYNGL-TLDV-DGRTTKKLITHLKPHTFYN-----FVLTNRGSSLGGLQQTVTAWTAFNL 690
Query: 761 -SAPENITYKNISSGEIELSFLPPSSPNGIIQKYTIY---LKRSNGNE 804
+ ++ K + G I + +LP +Q Y I L++S G +
Sbjct: 691 LNGKPSVAPKPDADGFI-MVYLPDGQSPVPVQSYFIVMVPLRKSRGGQ 737
Score = 63.2 bits (152), Expect = 3e-09
Identities = 82/390 (21%), Positives = 154/390 (39%), Gaps = 55/390 (14%)
Query: 45 VTRIVTTNVTK-PGPPVFLAGERVGSAGILLSWNTP-PNPNGRIISYIVKYKEVCPWMQT 102
V +I ++ K PG P+ + I ++W++ P+P + Y+++YK Q
Sbjct: 310 VAQITVKSLPKAPGTPMVTENT---ATSITITWDSGNPDP---VSYYVIEYKSKS---QD 360
Query: 103 VYTQVRSKPDSLEVLLTNLNPGTTYEIKVAAENSAGIGVFSDPFLFQTAESAPGKVV-NL 161
Q++ + + L+P + YEI V+A NS G G S+ + +T E AP N+
Sbjct: 361 GPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNV 420
Query: 162 TVEAYNASAVKLIWYLPRQPNGKITSFKISVKHARSGIVVKDVSIRVEDILTGKLPECNE 221
+A+ + + W P +PNG I +++ V V+D L + E
Sbjct: 421 QARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLE 480
Query: 222 NSESFLWSTASPSPTLGRVTPPSRT------------------THSSSTLTQN------- 256
+ + A S G ++ P + + +S TL+ +
Sbjct: 481 DETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPRQESI 540
Query: 257 --------------EISSVWKEPISFVVTHLRPYTTYLFEVSAATTEAGYIDSTIVRTPE 302
E+ + S+VV L+P T Y F ++A + + + +VR
Sbjct: 541 IKYELLFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVR-QR 599
Query: 303 SVPEGPPQNCVTGNITGKSFSILWDPPTIVTGKFSYRVELYGPSGRILDNSTKDLKFAFT 362
++ P+N I S + W+ P Y+++ +G LD + K T
Sbjct: 600 TLQSISPKNFKVKMIMKTSVLLSWEFPDNYNSPTPYKIQY---NGLTLDVDGRTTKKLIT 656
Query: 363 NLTPFTMYDVYIAAETSAGTGPKSNISVFT 392
+L P T Y+ + S+ G + ++ +T
Sbjct: 657 HLKPHTFYNFVLTNRGSSLGGLQQTVTAWT 686
Score = 62.0 bits (149), Expect = 7e-09
Identities = 74/311 (23%), Positives = 135/311 (43%), Gaps = 20/311 (6%)
Query: 1066 SSTAINVSWVPPAQPNGLVFYYVSLIL--QQTPRHVRPPLVTYERSIYFDNLEKYTDYIL 1123
++T+I ++W P+ + +Y + Q P ++ + T SI L ++Y +
Sbjct: 331 TATSITITW-DSGNPDPVSYYVIEYKSKSQDGPYQIKEDITTTRYSI--GGLSPNSEYEI 387
Query: 1124 KITPSTEKGFSDTYTAQLYIKTEEDVPETSPIINTFKNLSSTSVLLSWDPPVKPNGAI-- 1181
++ G + + +T E P ++P + LS+T++++ W+ PV+PNG I
Sbjct: 388 WVSAVNSIGQGPP-SESVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRG 446
Query: 1182 --ISYDLTLQGPNENYSFITSDNYII--LEELSPFTLYSFFAAARTRKGLGP-SSILFFY 1236
+ Y + + P N+ D+ ++ + L Y+ A T G GP S +
Sbjct: 447 YRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVK 506
Query: 1237 TDESVPLAPPQNLTLINCTSDFVWLKWSPSPLPGGIVKVYSFKIHEHETDTIYYKNISGF 1296
T + VP P NL + + L WSP P I+K Y E + +
Sbjct: 507 TQQGVP-GQPMNLRAEARSETSITLSWSP-PRQESIIK-YELLFREGDHGREVGRTFDP- 562
Query: 1297 KTEAKLVGLEPVSTYSIRVSAFTKVGNGNQFSNVVKFTTQESVPDVVQNMQCMATSWQSV 1356
T + L+P + Y+ R++A + G G F+ VV+ T +S+ +N + SV
Sbjct: 563 TTSYVVEDLKPNTEYAFRLAARSPQGLG-AFTPVVRQRTLQSISP--KNFKVKMIMKTSV 619
Query: 1357 LVKWDPPKKAN 1367
L+ W+ P N
Sbjct: 620 LLSWEFPDNYN 630
Score = 57.8 bits (138), Expect = 1e-07
Identities = 52/219 (23%), Positives = 86/219 (39%), Gaps = 14/219 (6%)
Query: 213 TGKLPECNENSESFLWSTASPSPTLGRVTPPSRTTHSSSTLTQNEISSVWKEPISFVVTH 272
T + E S + W + +P P V + + +I++ + +
Sbjct: 324 TPMVTENTATSITITWDSGNPDPVSYYVIEYKSKSQDGPYQIKEDITTT-----RYSIGG 378
Query: 273 LRPYTTYLFEVSAATT--EAGYIDSTIVRTPESVPEGPPQNCVTGNITGKSFSILWDPPT 330
L P + Y VSA + + +S + RT E P P+N ++ + + W+ P
Sbjct: 379 LSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPV 438
Query: 331 IVTG-----KFSYRVELYGPSGRILDNSTKD-LKFAFTNLTPFTMYDVYIAAETSAGTGP 384
G + Y +E P G ++ D L +L Y V + A TS G GP
Sbjct: 439 EPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVGDGP 498
Query: 385 KSN-ISVFTPPDVPGAVFDLQLAEVESTQVRITWKKPRQ 422
S+ I V T VPG +L+ T + ++W PRQ
Sbjct: 499 LSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPRQ 537
Score = 53.5 bits (127), Expect = 2e-06
Identities = 91/405 (22%), Positives = 159/405 (39%), Gaps = 52/405 (12%)
Query: 1335 TQESVPDVVQNMQCMATSWQSVLVKWDPPKKANGIITQYMVTVERNSTKVSPQDHMYTFI 1394
+ E +P N+ C+A VKW + A + + + V RN ++ T +
Sbjct: 240 SHEIMPGGNVNITCVAVGSPMPYVKW--MQGAEDLTPEDDMPVGRNVLEL-------TDV 290
Query: 1395 KLLANTSYVFKVRASTSAGEGDESTCHVSTLPETVPSVPTNIAFSDVQSTSATLTWI--R 1452
K AN + V A +S G E+ ++ +++P P ++ +TS T+TW
Sbjct: 291 KDSANYTCV----AMSSLGV-IEAVAQITV--KSLPKAPGTPMVTENTATSITITWDSGN 343
Query: 1453 PDTILGYFQNYKITTQLRAQKCKEWESEECVEYQKIQYLYEAHLTEETVYGLKKFRWYRF 1512
PD + Y YK +Q + KE + T ++ GL Y
Sbjct: 344 PDPVSYYVIEYKSKSQDGPYQIKE----------------DITTTRYSIGGLSPNSEYEI 387
Query: 1513 QVAASTNAGYGNASNWISTKTLPGPPDGPPENVHVVATSPFSISISWSEPAVITGPTCYL 1572
V+A + G G S + T+T P P NV S ++ + W EP G
Sbjct: 388 WVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGY 447
Query: 1573 IDVKSVDNDEFNISFIKSNEENKTI-EIKDLEIFTRYSVVITAFTGNISAAYVEGKSSAE 1631
+++ + ++ K N ++ + + L Y+V + AFT + +G S
Sbjct: 448 RVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFT-----SVGDGPLSDP 502
Query: 1632 MIVTTLESAPKDPPNNMTFQKIPDEVTKFQLTFLPPSQPNGNIQVYQALVYREDDPTAVQ 1691
+ V T + P P N + +T L++ PP Q +I Y+ L++RE D
Sbjct: 503 IQVKTQQGVPGQPMNLRAEARSETSIT---LSWSPPRQE--SIIKYE-LLFREGD----- 551
Query: 1692 IHNLSIIQKTNTFVIAMLEGLKGGHTYNISVYAVNSAGAGPKVPM 1736
H + + + ++E LK Y + A + G G P+
Sbjct: 552 -HGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPV 595
>gi|219842266 usherin isoform B [Homo sapiens]
Length = 5202
Score = 269 bits (687), Expect = 3e-71
Identities = 367/1537 (23%), Positives = 609/1537 (39%), Gaps = 192/1537 (12%)
Query: 4 LIIFLLL------FIGTSETQVDVSNVVPGTRYDITISSISTTYTSPVTRIVTTNVTKPG 57
+I ++LL F GTS + D + P Y + + + + +++V T G
Sbjct: 3531 IIYYILLRNGIERFRGTSLSFSDKEGIQPFQEYSYQLKACTVAGCATSSKVVAA--TTQG 3588
Query: 58 PPVFLAGERV---GSAGILLSWNTPPNPNGRIISYIVKYKEVCPWMQTVYTQVRSKPDSL 114
P + + + + LSW+ P NG I Y ++ ++T D
Sbjct: 3589 VPESILPPSITALSAVALHLSWSVPEKSNGVIKEYQIRQVG----KGLIHTDTT---DRR 3641
Query: 115 EVLLTNLNPGTTYEIKVAAENSAGIGVFSDPFLFQTAESAP-GKVVNLTVEAYNASAVKL 173
+ +T L P T Y + A SAG S+PFL QT ++AP G V N++ V+L
Sbjct: 3642 QHTVTGLQPYTNYSFTLTACTSAGC-TSSEPFLGQTLQAAPEGVWVTPRHIIINSTTVEL 3700
Query: 174 IWYLPRQPNGKITSFKISVKHARSGIVV----------KDVSIRVEDILTGKLP--ECNE 221
W LP +PNG ++ +++S R+G ++ D ++ T KL
Sbjct: 3701 YWSLPEKPNGLVSQYQLS----RNGNLLFLGGSEEQNFTDKNLEPNSRYTYKLEVKTGGG 3756
Query: 222 NSESFLWSTASPSPTLGRVTPPSRTTHSSSTLTQNEISSVW------------------- 262
+S S + +P T + PP T + I W
Sbjct: 3757 SSASDDYIVQTPMSTPEEIYPPYNIT----VIGPYSIFVAWIPPGILIPEIPVEYNVLLN 3812
Query: 263 ---KEPISFVVTH--------LRPYTTYLFEVSAATT-EAGYIDSTIVRTPESVPEGPPQ 310
P++F V H L P+T Y + A G V+TPE+ P
Sbjct: 3813 DGSVTPLAFSVGHHQSTLLENLTPFTQYEIRIQACQNGSCGVSSRMFVKTPEAAPMDL-N 3871
Query: 311 NCVTGNITGKSFSILWDPPT----IVTGKFSYRVELYGPSGRIL---DNSTKDLKFAFTN 363
+ V + I W PP I+ F YR +L +
Sbjct: 3872 SPVLKALGSACIEIKWMPPEKPNGIIINYFIYRRPAGIEEESVLFVWSEGALEFMDEGDT 3931
Query: 364 LTPFTMYDVYIAAETSAGTGPKSNISVFTPPDVPGAVFDLQLAEVESTQ-VRITWKKPRQ 422
L PFT+Y+ + A S G+ +S S+ + P F A+ S V + W KP
Sbjct: 3932 LRPFTLYEYRVRACNSKGS-VESLWSLTQTLEAPPQDFPAPWAQATSAHSVLLNWTKPES 3990
Query: 423 PNGIINQYRVKVLV-PETGIILENTL-------------LTGNNEYINDPMAPEIVNIVE 468
PNGII+ YRV P+ T+ L G + + N
Sbjct: 3991 PNGIISHYRVVYQERPDDPTFNSPTVHAFTVKGTSHQAHLYGLEPFTTYRIGVVAANHAG 4050
Query: 469 PMVGLYEGSAEMSSDLHSLATFIYNSHPDKNFPARNRAED-QTSPVVTTRNQY---ITDI 524
++ + + S L FI + +E +T+ V+ T N + +
Sbjct: 4051 EILSPWTLIQTLESSPSGLRNFIVEQKENGRALLLQWSEPMRTNGVIKTYNIFSDGFLEY 4110
Query: 525 AAEQLSYVIRRLVPFTEHMISVSAFTIMGEGPPTVLSVRTRQQVPSSIKIINYKNISSSS 584
+ ++ RRL PFT + +++ A T G + T + P S ++ S+S
Sbjct: 4111 SGLNRQFLFRRLDPFTLYTLTLEACTRAGCAHSAPQPLWTDEAPPDSQLAPTVHSVKSTS 4170
Query: 585 ILLYWDPPEYPNGKITHYTIY------------AMELDTNRAF-QITTIDNSFLI--TGL 629
+ L W P PNGKI Y + ++ D F + T N+F+ TGL
Sbjct: 4171 VELSWSEPVNPNGKIIRYEVIRRCFEGKAWGNQTIQADEKIVFTEYNTERNTFMYNDTGL 4230
Query: 630 KKYTKYKMRVAASTHVGESSLSEENDIFVRTSEDEPES-SPQDVEVIDVTADEIRLKWSP 688
+ +T+ + ++ G + S VRT + PE SP + + + ++ + W P
Sbjct: 4231 QPWTQCEYKIYTWNSAGHTCSSWN---VVRTLQAPPEGLSPPVISYVSMNPQKLLISWIP 4287
Query: 689 PEKPNGIIIAYEVLYKNIDTLYMKNTSTTDIILRNLRPHTLYNISVRSYTRFGHGNQVSS 748
PE+ NGII +Y + + + + T + L P + Y+ ++++ T G
Sbjct: 4288 PEQSNGIIQSYRLQRNEMLYPFSFDPVTFNYTDEELLPFSTYSYALQACTSGGCST---- 4343
Query: 749 LLSVRTSETVPDSAPENITYKN---ISSGEIELSFLPPSSPNGIIQKYTIYLKRSNGNEE 805
S TS T ++AP ++ + +S+ ++ + + PP+ NG I KY + + +
Sbjct: 4344 --SKPTSITTLEAAPSEVSPPDLWAVSATQMNVCWSPPTVQNGKITKYLVRY-----DNK 4396
Query: 806 RTINTTSLTQNIKVLKKYTQYIIEVSASTLKGEGVRSAPISILTEEDAPDSPPQDFSVKQ 865
++ L + L+ Y+QY + A T G S S T E P++ D Q
Sbjct: 4397 ESLAGQGLCLLVSHLQPYSQYNFSLVACT-NGGCTASVSKSAWTMEALPEN--MDSPTLQ 4453
Query: 866 LSGV-TVKLSWQPPLEPNGIILYYTVYVWNRSSLKTINVTETSLELSDLDYNVEYSAYVT 924
++G +++++W+PP PNG I Y + R ET L VEYS VT
Sbjct: 4454 VTGSESIEITWKPPRNPNGQIRSYEL---RRDGTIVYTGLETRYRDFTLTPGVEYSYTVT 4510
Query: 925 ASTRFGDGKTRSNIISFQTPEGAPS--DPPKDVYYANLSSSSIILFWTPPSKPNGIIQYY 982
AS G S ++ +T APS +PPK I++ W PP + NG I Y
Sbjct: 4511 ASN--SQGGILSPLVKDRTSPSAPSGMEPPK---LQARGPQEILVNWDPPVRTNGDIINY 4565
Query: 983 SVYYRNTSGTFMQNFTLHEVTNDFDNMTVSTIIDKLTIFSYYTFWLTASTSVGNGNKSSD 1042
+++ R + ++ N F S I+++L F Y + A T++G +
Sbjct: 4566 TLFIRELFERETKIIHINTTHNSFGMQ--SYIVNQLKPFHRYEIRIQACTTLGCASSDWT 4623
Query: 1043 II---EVYTDQDIPEGFVGNLTYESISSTAINVSWVPPAQPNGLVFYYVSLILQ--QTPR 1097
I E+ P + T +++ W P QPNG V YY Q PR
Sbjct: 4624 FIQTPEIAPLMQPPPHLEVQMAPGGFQPT-VSLLWTGPLQPNGKVLYYELYRRQIATQPR 4682
Query: 1098 HVRPPLVTYERSIYFDNLE--KYTDYILKITPSTEKGFSDTYTAQLYIKTEEDVPE--TS 1153
P L+ S F + E +T+Y ++ G + + + + +T PE +
Sbjct: 4683 KSNPVLIYNGSSTSFIDSELLPFTEYEYQVWAVNSAGKAPS--SWTWCRTGPAPPEGLRA 4740
Query: 1154 PIINTFKNLSSTSVLLSWDPPVKPNGAIISYDLTLQGPNENYSFITSD--NYIILEELSP 1211
P TF +SST +++ P KPNG + Y L + + ++ L L
Sbjct: 4741 P---TFHVISSTQAVVNISAPGKPNGIVSLYRLFSSSAHGAETVLSEGMATQQTLHGLQA 4797
Query: 1212 FTLYSFFAAARTRKGL---GPSSILFFYTDESVPLAPPQNLTLINCTSDFVWLKWSPSPL 1268
FT YS A T GP++ L + L+ PQ TL + T+ F +WSP
Sbjct: 4798 FTNYSIGVEACTCFNCCSKGPTAELRTHPAPPSGLSSPQIGTLASRTASF---RWSPPMF 4854
Query: 1269 PGGIVKVYSFKIH------------EHETDTIYYKNISGFKTEAKLVGLEPVSTYSIRVS 1316
P G++ Y + H + +T Y +G +A L GL+P +TY +RV
Sbjct: 4855 PNGVIHSYELQFHVACPPDSALPCTPSQIETKY----TGLGQKASLGGLQPYTTYKLRVV 4910
Query: 1317 AFTKVGNGNQFSNVVKFTTQESVPDVVQNMQCMATSWQSVLVKWDPPKKANGIITQYMVT 1376
A +V G+ S + FTTQ+ +P + ++ V V W NG + +Y++T
Sbjct: 4911 AHNEV--GSTASEWISFTTQKELPQYRAPFS-VDSNLSVVCVNWSDTFLLNGQLKEYVLT 4967
Query: 1377 VERNSTKVSPQDHMYTFIKLLANTSYVFKVRASTSAG 1413
+V +I A+ ++ F+V +T G
Sbjct: 4968 --DGGRRVYSGLDTTLYIPRTADKTFFFQVICTTDEG 5002
Score = 263 bits (673), Expect = 1e-69
Identities = 331/1300 (25%), Positives = 516/1300 (39%), Gaps = 163/1300 (12%)
Query: 538 PFTEHMISVSAFTIMGEGPPTVLSVRTRQQVPSSIKIINYKNISSSSILLYWDPPEYPNG 597
PF E+ + A T+ G + + T Q VP SI + +S+ ++ L W PE NG
Sbjct: 3559 PFQEYSYQLKACTVAGCATSSKVVAATTQGVPESILPPSITALSAVALHLSWSVPEKSNG 3618
Query: 598 KITHYTIYAMELDTNRAFQITTIDNSFLITGLKKYTKYKMRVAASTHVGESSLSEENDIF 657
I Y I ++ TT +TGL+ YT Y + A T G +S
Sbjct: 3619 VIKEYQI--RQVGKGLIHTDTTDRRQHTVTGLQPYTNYSFTLTACTSAGCTS---SEPFL 3673
Query: 658 VRTSEDEPESSPQDVEVIDVTADEIRLKWSPPEKPNGIIIAYEVLYKNIDTLYMKNTSTT 717
+T + PE I + + + L WS PEKPNG++ Y+ L +N + L++ +
Sbjct: 3674 GQTLQAAPEGVWVTPRHIIINSTTVELYWSLPEKPNGLVSQYQ-LSRNGNLLFLGGSEEQ 3732
Query: 718 DIILRNLRPHTLYNISVRSYTRFGHGNQVSSLLSVRTSETVPDS--APENITYKNISSGE 775
+ +NL P++ Y + T G G+ S V+T + P+ P NIT I
Sbjct: 3733 NFTDKNLEPNSRYTYKLEVKT--GGGSSASDDYIVQTPMSTPEEIYPPYNITV--IGPYS 3788
Query: 776 IELSFLPPS--SPNGIIQKYTIYLKR--------SNGNEERTINTTSLTQNIKVLKKYTQ 825
I ++++PP P I +Y + L S G+ + T+ ++ L +TQ
Sbjct: 3789 IFVAWIPPGILIPE-IPVEYNVLLNDGSVTPLAFSVGHHQSTL--------LENLTPFTQ 3839
Query: 826 YIIEVSASTLKGEGVRSAPISILTEEDAP---DSPPQDFSVKQLSGVTVKLSWQPPLEPN 882
Y I + A GV S+ + + T E AP +SP +K L +++ W PP +PN
Sbjct: 3840 YEIRIQACQNGSCGV-SSRMFVKTPEAAPMDLNSP----VLKALGSACIEIKWMPPEKPN 3894
Query: 883 GIILYYTVY-------------VWNRSSLKTINVTETSLELSDLDYNVEYSAYVTASTRF 929
GII+ Y +Y VW+ +L+ ++ +T + +Y V
Sbjct: 3895 GIIINYFIYRRPAGIEEESVLFVWSEGALEFMDEGDTLRPFTLYEYRVRACN-------- 3946
Query: 930 GDGKTRSNIISFQTPEGAPSDPPKDVYYANLSSSSIILFWTPPSKPNGIIQYYSVYY--R 987
G S QT E P D P A S+ S++L WT P PNGII +Y V Y R
Sbjct: 3947 SKGSVESLWSLTQTLEAPPQDFPAPWAQAT-SAHSVLLNWTKPESPNGIISHYRVVYQER 4005
Query: 988 NTSGTFMQNFTLHEVTNDFDNMTVSTIIDKLTIFSYYTFWLTASTSVGNGNKSSDIIEVY 1047
TF + T+H T + + L F+ Y + A+ G +I+
Sbjct: 4006 PDDPTF-NSPTVHAFT--VKGTSHQAHLYGLEPFTTYRIGVVAANHAGEILSPWTLIQ-- 4060
Query: 1048 TDQDIPEGFVGNLTYESISSTAINVSWVPPAQPNGLVFYYVSLILQQTPRHVRPPLVTY- 1106
T + P G + + + A+ + W P + NG++ +T + Y
Sbjct: 4061 TLESSPSGLRNFIVEQKENGRALLLQWSEPMRTNGVI---------KTYNIFSDGFLEYS 4111
Query: 1107 --ERSIYFDNLEKYTDYILKITPSTEKGFSDTYTAQLYIKTEEDVPETSPIINTFKNLSS 1164
R F L+ +T Y L + T G + + L+ ++ P S + T ++ S
Sbjct: 4112 GLNRQFLFRRLDPFTLYTLTLEACTRAGCAHSAPQPLW---TDEAPPDSQLAPTVHSVKS 4168
Query: 1165 TSVLLSWDPPVKPNGAIISYDL---TLQGPNENYSFITSDNYIILEE------------- 1208
TSV LSW PV PNG II Y++ +G I +D I+ E
Sbjct: 4169 TSVELSWSEPVNPNGKIIRYEVIRRCFEGKAWGNQTIQADEKIVFTEYNTERNTFMYNDT 4228
Query: 1209 -LSPFTLYSFFAAARTRKGLGPSSILFFYTDESVP--LAPPQNLTLINCTSDFVWLKWSP 1265
L P+T + G SS T ++ P L+PP ++ ++ + + W P
Sbjct: 4229 GLQPWTQCEYKIYTWNSAGHTCSSWNVVRTLQAPPEGLSPPV-ISYVSMNPQKLLISWIP 4287
Query: 1266 SPLPGGIVKVYSFKIHEHETDTIYYKNISGFKTEAKLVGLEPVSTYSIRVSAFTKVGNGN 1325
GI++ Y + +E + + E L P STYS + A T G
Sbjct: 4288 PEQSNGIIQSYRLQRNEMLYPFSFDPVTFNYTDEELL----PFSTYSYALQACT--SGGC 4341
Query: 1326 QFSNVVKFTTQESVPDVVQNMQCMATSWQSVLVKWDPPKKANGIITQYMVTVERNSTKVS 1385
S TT E+ P V A S + V W PP NG IT+Y+V + N ++
Sbjct: 4342 STSKPTSITTLEAAPSEVSPPDLWAVSATQMNVCWSPPTVQNGKITKYLVRYD-NKESLA 4400
Query: 1386 PQDHMYTFIKLLANTSYVFKVRASTSAGEGDESTCHVSTLPETVPSVPTNIAFSDVQ--- 1442
Q L + Y F + A T+ G T VS T+ ++P N+ +Q
Sbjct: 4401 GQGLCLLVSHLQPYSQYNFSLVACTNGG----CTASVSKSAWTMEALPENMDSPTLQVTG 4456
Query: 1443 STSATLTWIRPDTILGYFQNYKITTQLRAQKCKEWESEECVEYQKIQYLYEAHLTEETVY 1502
S S +TW P G ++Y E + + Y ++ Y V
Sbjct: 4457 SESIEITWKPPRNPNGQIRSY------------ELRRDGTIVYTGLETRYRDFTLTPGVE 4504
Query: 1503 GLKKFRWYRFQVAASTNAGYGNASNWISTKTLPGPPDG--PPENVHVVATSPFSISISWS 1560
Y + V AS + G G S + +T P P G PP+ + A P I ++W
Sbjct: 4505 -------YSYTVTASNSQG-GILSPLVKDRTSPSAPSGMEPPK---LQARGPQEILVNWD 4553
Query: 1561 EPAVITGPTC-YLIDVKSVDNDEFNISFIKSNEEN---KTIEIKDLEIFTRYSVVITAFT 1616
P G Y + ++ + E I I + + ++ + L+ F RY + I A T
Sbjct: 4554 PPVRTNGDIINYTLFIRELFERETKIIHINTTHNSFGMQSYIVNQLKPFHRYEIRIQACT 4613
Query: 1617 GNISAAYVEGKSSAEMIVTTLESAP-KDPPNNMTFQKIPDEV-TKFQLTFLPPSQPNGNI 1674
+ A SS + T E AP PP ++ Q P L + P QPNG +
Sbjct: 4614 -TLGCA-----SSDWTFIQTPEIAPLMQPPPHLEVQMAPGGFQPTVSLLWTGPLQPNGKV 4667
Query: 1675 QVYQALVYREDDPTAVQIHNLSIIQKTNTFVIAMLEGLKGGHTYNISVYAVNSAGAGPKV 1734
Y+ +YR T + N +I ++ E L Y V+AVNSAG K
Sbjct: 4668 LYYE--LYRRQIATQPRKSNPVLIYNGSSTSFIDSE-LLPFTEYEYQVWAVNSAG---KA 4721
Query: 1735 PMRITMDIKAPARPKTKPTPIYDATGKLLVTSTTITIRMP 1774
P T PA P+ P + T + I P
Sbjct: 4722 PSSWTWCRTGPAPPEGLRAPTFHVISS---TQAVVNISAP 4758
Score = 255 bits (651), Expect = 4e-67
Identities = 357/1426 (25%), Positives = 554/1426 (38%), Gaps = 204/1426 (14%)
Query: 72 ILLSWNTPPNPNGRIISYIVKYKEVCPWMQTVYTQVRSKPDSLEVLLTNLNPGTTYEIKV 131
I+L+W P NG II YI+ + + T + + + P Y ++
Sbjct: 3517 IVLNWRKPIQSNGPIIYYILLRNGIERFRGTSLSFSDKE---------GIQPFQEYSYQL 3567
Query: 132 AAENSAGIGVFSDPFLFQTAESAPGKVVNLTVEAYNASAVKLIWYLPRQPNGKITSFKIS 191
A AG S + T + P ++ ++ A +A A+ L W +P + NG I ++I
Sbjct: 3568 KACTVAGCAT-SSKVVAATTQGVPESILPPSITALSAVALHLSWSVPEKSNGVIKEYQI- 3625
Query: 192 VKHARSGIVVKDVSIRVEDILTGKLPECN-------------ENSESFLWSTASPSPTLG 238
+ G++ D + R + +TG P N +SE FL T +P
Sbjct: 3626 -RQVGKGLIHTDTTDRRQHTVTGLQPYTNYSFTLTACTSAGCTSSEPFLGQTLQAAPEGV 3684
Query: 239 RVTPPSRTTHSSST-------------LTQNEISSVWK-------EPISFVVTHLRPYTT 278
VTP +S++ ++Q ++S E +F +L P +
Sbjct: 3685 WVTPRHIIINSTTVELYWSLPEKPNGLVSQYQLSRNGNLLFLGGSEEQNFTDKNLEPNSR 3744
Query: 279 YLFEVSAATTEAGYI-DSTIVRTPESVPEG--PPQNCVTGNITGKSFSILWDPPTIVTGK 335
Y +++ T D IV+TP S PE PP N I S + W PP I+ +
Sbjct: 3745 YTYKLEVKTGGGSSASDDYIVQTPMSTPEEIYPPYNITV--IGPYSIFVAWIPPGILIPE 3802
Query: 336 FSYRVELYGPSGRILDNSTKDLKFA--------FTNLTPFTMYDVYIAAETSAGTGPKSN 387
+ + D S L F+ NLTPFT Y++ I A + G S
Sbjct: 3803 IPVEYNVL-----LNDGSVTPLAFSVGHHQSTLLENLTPFTQYEIRIQACQNGSCGVSSR 3857
Query: 388 ISVFTPPDVPGAVFDLQLAEVESTQVRITWKKPRQPNGIINQYRVKVLVPETGIILENTL 447
+ V TP P + L + S + I W P +PNGII Y + GI E+ L
Sbjct: 3858 MFVKTPEAAPMDLNSPVLKALGSACIEIKWMPPEKPNGIIINY--FIYRRPAGIEEESVL 3915
Query: 448 LT---GNNEYINDPMAPEIVNIVEPMVGLYEGSAEMSSDLHSLATFIYNSHPDKNFPA-- 502
G E++++ + E V + S L SL + P ++FPA
Sbjct: 3916 FVWSEGALEFMDEGDTLRPFTLYEYRVRACNSKGSVES-LWSLTQTL--EAPPQDFPAPW 3972
Query: 503 ------------------------------RNRAEDQT--SPVVTTRNQYITDIAAEQLS 530
+ R +D T SP V T A
Sbjct: 3973 AQATSAHSVLLNWTKPESPNGIISHYRVVYQERPDDPTFNSPTVHAFTVKGTSHQAH--- 4029
Query: 531 YVIRRLVPFTEHMISVSAFTIMGEGPPTVLSVRTRQQVPSSIK--IINYKNISSSSILLY 588
+ L PFT + I V A GE ++T + PS ++ I+ K + ++LL
Sbjct: 4030 --LYGLEPFTTYRIGVVAANHAGEILSPWTLIQTLESSPSGLRNFIVEQKE-NGRALLLQ 4086
Query: 589 WDPPEYPNGKITHYTIYAMELDTNRAFQITTIDNSFLITGLKKYTKYKMRVAASTHVGES 648
W P NG I Y I+ ++ + + ++ FL L +T Y + + A T G +
Sbjct: 4087 WSEPMRTNGVIKTYNIF-----SDGFLEYSGLNRQFLFRRLDPFTLYTLTLEACTRAGCA 4141
Query: 649 SLSEENDIFVRTSEDEPESSPQDVEVIDVTADEIRLKWSPPEKPNGIIIAYEVL------ 702
+ + +++ P S V V + + L WS P PNG II YEV+
Sbjct: 4142 HSAPQ----PLWTDEAPPDSQLAPTVHSVKSTSVELSWSEPVNPNGKIIRYEVIRRCFEG 4197
Query: 703 -----------YKNIDTLYMKNTSTTDIILRNLRPHTLYNISVRSYTRFGHGNQVSSLLS 751
K + T Y +T L+P T + ++ GH SS
Sbjct: 4198 KAWGNQTIQADEKIVFTEYNTERNTFMYNDTGLQPWTQCEYKIYTWNSAGH--TCSSWNV 4255
Query: 752 VRTSETVPDS-APENITYKNISSGEIELSFLPPSSPNGIIQKYTIYLKRSNGNEERTINT 810
VRT + P+ +P I+Y +++ ++ +S++PP NGIIQ Y L+R+ + +
Sbjct: 4256 VRTLQAPPEGLSPPVISYVSMNPQKLLISWIPPEQSNGIIQSYR--LQRNEMLYPFSFDP 4313
Query: 811 TSLTQNIKVLKKYTQYIIEVSASTLKGEGVRSAPISILTEEDAPD--SPPQDFSVKQLSG 868
+ + L ++ Y + A T G S P SI T E AP SPP ++V S
Sbjct: 4314 VTFNYTDEELLPFSTYSYALQACT-SGGCSTSKPTSITTLEAAPSEVSPPDLWAV---SA 4369
Query: 869 VTVKLSWQPPLEPNGIILYYTVYVWNRSSLKTINVTETSLELSDLDYNVEYSAYVTASTR 928
+ + W PP NG I Y V N+ SL + L +S L +Y+ + A T
Sbjct: 4370 TQMNVCWSPPTVQNGKITKYLVRYDNKESLAGQGL---CLLVSHLQPYSQYNFSLVACT- 4425
Query: 929 FGDGKTRSNIISFQTPEGAPSDPPKDVYYANLSSSSIILFWTPPSKPNGIIQYYSVYYRN 988
G T S S T E P + S SI + W PP PNG I+ Y +
Sbjct: 4426 -NGGCTASVSKSAWTMEALPENMDSPTLQVT-GSESIEITWKPPRNPNGQIRSYEL---R 4480
Query: 989 TSGTFMQNFTLHEVTNDFDNMTVSTIIDKLTIFSYYTFWLTASTSVGNGNKSSDIIEVYT 1048
GT + L DF LT Y++ +TAS S G S +++ T
Sbjct: 4481 RDGTIVYT-GLETRYRDF----------TLTPGVEYSYTVTASNS--QGGILSPLVKDRT 4527
Query: 1049 DQDIPEGFVGNLTYESISSTAINVSWVPPAQPNGLVFYYVSLILQQTPR-----HVRPPL 1103
P G + ++ I V+W PP + NG + Y I + R H+
Sbjct: 4528 SPSAPSG-MEPPKLQARGPQEILVNWDPPVRTNGDIINYTLFIRELFERETKIIHINTTH 4586
Query: 1104 VTYERSIYFDN-LEKYTDYILKITPSTEKGFSDTYTAQLYIKTEEDVPETSPIINTFKNL 1162
++ Y N L+ + Y ++I T G + + +I+T E P P + +
Sbjct: 4587 NSFGMQSYIVNQLKPFHRYEIRIQACTTLGCAS--SDWTFIQTPEIAPLMQPPPHLEVQM 4644
Query: 1163 S----STSVLLSWDPPVKPNGAIISYDL-----TLQGPNENYSFI--TSDNYIILEELSP 1211
+ +V L W P++PNG ++ Y+L Q N I S I EL P
Sbjct: 4645 APGGFQPTVSLLWTGPLQPNGKVLYYELYRRQIATQPRKSNPVLIYNGSSTSFIDSELLP 4704
Query: 1212 FTLYSFFAAARTRKGLGPSSILFFYTDESVPLAPPQNL---TLINCTSDFVWLKWSPSPL 1268
FT Y + A G PSS + T APP+ L T +S + S
Sbjct: 4705 FTEYEYQVWAVNSAGKAPSSWTWCRTGP----APPEGLRAPTFHVISSTQAVVNISAPGK 4760
Query: 1269 PGGIVKVYS-FKIHEHETDTIYYKNISGFKTEAKLVGLEPVSTYSIRVSAFTKVGNGNQF 1327
P GIV +Y F H +T+ + G T+ L GL+ + YSI V A T N
Sbjct: 4761 PNGIVSLYRLFSSSAHGAETVLSE---GMATQQTLHGLQAFTNYSIGVEACT-CFNCCSK 4816
Query: 1328 SNVVKFTTQESVPDVVQNMQCMATSWQSVLVKWDPPKKANGIITQY 1373
+ T + P + + Q + ++ +W PP NG+I Y
Sbjct: 4817 GPTAELRTHPAPPSGLSSPQIGTLASRTASFRWSPPMFPNGVIHSY 4862
Score = 252 bits (644), Expect = 3e-66
Identities = 346/1480 (23%), Positives = 572/1480 (38%), Gaps = 166/1480 (11%)
Query: 333 TGKFSYRVELYGPSGRILDNSTKDLKFAFTNLTPFTMYDVYIAAETSAGTGPKSNISVFT 392
TGK S I S + NL P+ Y+ I+A S G G + T
Sbjct: 3435 TGKASIEEMCSSAEETIHTGSVNTYSYTDVNLKPYMTYEYRISAWNSYGRGLSKAVRART 3494
Query: 393 PPDVPGAVFDLQLAEVESTQ--VRITWKKPRQPNGIINQYRVKVLVPETGIILENTLLTG 450
DVP V ++++ + + + W+KP Q NG I Y +L+ T L+
Sbjct: 3495 KEDVPQGVSPPTWTKIDNLEDTIVLNWRKPIQSNGPIIYY---ILLRNGIERFRGTSLSF 3551
Query: 451 NN--------EYINDPMAPEIVNIV---EPMVGLYEGSAEMSSDLHSLATFIYNSHPDKN 499
++ EY A + + + +G E A H +
Sbjct: 3552 SDKEGIQPFQEYSYQLKACTVAGCATSSKVVAATTQGVPESILPPSITALSAVALHLSWS 3611
Query: 500 FPARNRAEDQTSPVVTTRNQYITDIAAEQLSYVIRRLVPFTEHMISVSAFTIMGEGPPTV 559
P ++ + + I ++ + + L P+T + +++A T G
Sbjct: 3612 VPEKSNGVIKEYQIRQVGKGLIHTDTTDRRQHTVTGLQPYTNYSFTLTACTSAGCTSSEP 3671
Query: 560 LSVRTRQQVPSSIKII-NYKNISSSSILLYWDPPEYPNGKITHYTIYAMELDTNRAFQIT 618
+T Q P + + + I+S+++ LYW PE PNG ++ Y + + N F
Sbjct: 3672 FLGQTLQAAPEGVWVTPRHIIINSTTVELYWSLPEKPNGLVSQ---YQLSRNGNLLFLGG 3728
Query: 619 TIDNSFLITGLKKYTKYKMRVAASTHVGESSLSEENDIFVRTSEDEPESSPQDVEVIDVT 678
+ + +F L+ ++Y ++ T G S+ +D V+T PE + +
Sbjct: 3729 SEEQNFTDKNLEPNSRYTYKLEVKTGGGSSA---SDDYIVQTPMSTPEEIYPPYNITVIG 3785
Query: 679 ADEIRLKWSPPEKPNGIII-----AYEVLYK--NIDTLYMKNTSTTDIILRNLRPHTLYN 731
I + W PP GI+I Y VL ++ L +L NL P T Y
Sbjct: 3786 PYSIFVAWIPP----GILIPEIPVEYNVLLNDGSVTPLAFSVGHHQSTLLENLTPFTQYE 3841
Query: 732 ISVRSYTRFGHGNQVSSLLSVRTSETVPDSAPENITYKNISSGEIELSFLPPSSPNGIIQ 791
I +++ G VSS + V+T E P + K + S IE+ ++PP PNGII
Sbjct: 3842 IRIQACQNGSCG--VSSRMFVKTPEAAPMDLNSPV-LKALGSACIEIKWMPPEKPNGIII 3898
Query: 792 KYTIYLKRSNGNEERTI------NTTSLTQNIKVLKKYTQYIIEVSASTLKGEGVRSAPI 845
Y IY +R G EE ++ L+ +T Y V A KG +
Sbjct: 3899 NYFIY-RRPAGIEEESVLFVWSEGALEFMDEGDTLRPFTLYEYRVRACNSKG-----SVE 3952
Query: 846 SILTEEDAPDSPPQDFS---VKQLSGVTVKLSWQPPLEPNGIILYYTVYVWNRSSLKTIN 902
S+ + ++PPQDF + S +V L+W P PNGII +Y V R T N
Sbjct: 3953 SLWSLTQTLEAPPQDFPAPWAQATSAHSVLLNWTKPESPNGIISHYRVVYQERPDDPTFN 4012
Query: 903 V----------TETSLELSDLDYNVEYSAYVTASTRFGDGKTRSNIISFQTPEGAPSDPP 952
T L L+ Y V A+ G+ + +I QT E +PS
Sbjct: 4013 SPTVHAFTVKGTSHQAHLYGLEPFTTYRIGVVAANHAGEILSPWTLI--QTLESSPSGLR 4070
Query: 953 KDVYYANLSSSSIILFWTPPSKPNGIIQYYSVYYRNTSGTFMQNFTLHEVTNDFDNMTVS 1012
+ + +++L W+ P + NG+I+ Y+++ S F+ ++ +
Sbjct: 4071 NFIVEQKENGRALLLQWSEPMRTNGVIKTYNIF----SDGFL----------EYSGLNRQ 4116
Query: 1013 TIIDKLTIFSYYTFWLTASTSVGNGNKSSDIIEVYTDQDIPEGFVGNLTYESISSTAINV 1072
+ +L F+ YT L A T G + + ++TD+ P+ + T S+ ST++ +
Sbjct: 4117 FLFRRLDPFTLYTLTLEACTRAGCAHSAPQ--PLWTDEAPPDSQLAP-TVHSVKSTSVEL 4173
Query: 1073 SWVPPAQPNGLVFYYVSL------------ILQQTPRHVRPPLVTYERSIYFDN---LEK 1117
SW P PNG + Y + +Q + V T ER+ + N L+
Sbjct: 4174 SWSEPVNPNGKIIRYEVIRRCFEGKAWGNQTIQADEKIVFTEYNT-ERNTFMYNDTGLQP 4232
Query: 1118 YTDYILKITPSTEKGFSDTYTAQLYIKTEEDVPE-TSPIINTFKNLSSTSVLLSWDPPVK 1176
+T KI G T ++ ++T + PE SP + ++ +++ +L+SW PP +
Sbjct: 4233 WTQCEYKIYTWNSAG--HTCSSWNVVRTLQAPPEGLSPPVISYVSMNPQKLLISWIPPEQ 4290
Query: 1177 PNGAIISYDLTLQGPNENYSFITSDNYIILEELSPFTLYSFFAAARTRKGLGPSSILFFY 1236
NG I SY L +SF EEL PF+ YS+ A T G S
Sbjct: 4291 SNGIIQSYRLQRNEMLYPFSFDPVTFNYTDEELLPFSTYSYALQACTSGGCSTSKPTSIT 4350
Query: 1237 TDESVPL-APPQNLTLINCTSDFVWLKWSPSPLPGGIVKVYSFKIHEHETDTIYYKNISG 1295
T E+ P P +L ++ T V WSP + G + Y + E +++G
Sbjct: 4351 TLEAAPSEVSPPDLWAVSATQMNVC--WSPPTVQNGKITKYLVRYDNKE-------SLAG 4401
Query: 1296 FKTEAKLVGLEPVSTYSIRVSAFTKVGNGNQFSNVVKFT-TQESVPDVVQNMQCMATSWQ 1354
+ L+P S Y+ + A T NG ++V K T E++P+ + + T +
Sbjct: 4402 QGLCLLVSHLQPYSQYNFSLVACT---NGGCTASVSKSAWTMEALPENMDSPTLQVTGSE 4458
Query: 1355 SVLVKWDPPKKANGIITQYMVTVERNSTKV-SPQDHMYTFIKLLANTSYVFKVRASTSAG 1413
S+ + W PP+ NG I Y + R+ T V + + Y L Y + V AS S G
Sbjct: 4459 SIEITWKPPRNPNGQIRSY--ELRRDGTIVYTGLETRYRDFTLTPGVEYSYTVTASNSQG 4516
Query: 1414 EGDESTCHVSTLPETVPSVPTNIAFSDVQS---TSATLTWIRPDTILGYFQNYKITTQLR 1470
T PS P+ + +Q+ + W P G NY + +
Sbjct: 4517 ----GILSPLVKDRTSPSAPSGMEPPKLQARGPQEILVNWDPPVRTNGDIINYTLFIR-- 4570
Query: 1471 AQKCKEWESEECVEYQKIQYLYEAH----LTEETVYGLKKFRWYRFQVAASTNAGYGNAS 1526
+ +E E KI ++ H + V LK F Y ++ A T G +S
Sbjct: 4571 ----ELFERE-----TKIIHINTTHNSFGMQSYIVNQLKPFHRYEIRIQACTTLGCA-SS 4620
Query: 1527 NWISTKTLP-GPPDGPPENVHV-VATSPF--SISISWSEPAVITGPTCY--LIDVKSVDN 1580
+W +T P PP ++ V +A F ++S+ W+ P G Y L +
Sbjct: 4621 DWTFIQTPEIAPLMQPPPHLEVQMAPGGFQPTVSLLWTGPLQPNGKVLYYELYRRQIATQ 4680
Query: 1581 DEFNISFIKSNEENKTIEIKDLEIFTRYSVVITAFTGNISAAYVEGKSSAEMIVTTLESA 1640
+ + N + + +L FT Y + A GK+ + A
Sbjct: 4681 PRKSNPVLIYNGSSTSFIDSELLPFTEYEYQVWAVNS-------AGKAPSSWTWCRTGPA 4733
Query: 1641 PKDPPNNMTFQKIPDEVTKFQLTFLPPSQPNGNIQVYQALVYREDDPTAVQIHNLSIIQK 1700
P + TF I T+ + P +PNG + +Y+ + H +
Sbjct: 4734 PPEGLRAPTFHVISS--TQAVVNISAPGKPNGIVSLYRLF--------SSSAHGAETVLS 4783
Query: 1701 TNTFVIAMLEGLKGGHTYNISVYA---VNSAGAGPKVPMR 1737
L GL+ Y+I V A N GP +R
Sbjct: 4784 EGMATQQTLHGLQAFTNYSIGVEACTCFNCCSKGPTAELR 4823
Score = 252 bits (644), Expect = 3e-66
Identities = 371/1541 (24%), Positives = 611/1541 (39%), Gaps = 160/1541 (10%)
Query: 267 SFVVTHLRPYTTYLFEVSAATTEAGYIDSTI-VRTPESVPEG--PPQNCVTGNITGKSFS 323
S+ +L+PY TY + +SA + + + RT E VP+G PP N+ +
Sbjct: 3460 SYTDVNLKPYMTYEYRISAWNSYGRGLSKAVRARTKEDVPQGVSPPTWTKIDNLED-TIV 3518
Query: 324 ILWDPPTIVTGKFSYRVELYGPSGRILDNSTKDLKFAFTN-LTPFTMYDVYIAAETSAGT 382
+ W P G Y + L R S L F+ + PF Y + A T AG
Sbjct: 3519 LNWRKPIQSNGPIIYYILLRNGIERFRGTS---LSFSDKEGIQPFQEYSYQLKACTVAGC 3575
Query: 383 GPKSNISVFTPPDVPGAVFDLQLAEVESTQVRITWKKPRQPNGIINQYRVKVLVPETGII 442
S + T VP ++ + + + + ++W P + NG+I +Y+++ + G+I
Sbjct: 3576 ATSSKVVAATTQGVPESILPPSITALSAVALHLSWSVPEKSNGVIKEYQIRQV--GKGLI 3633
Query: 443 LENT------LLTGNNEYINDPMAPEIVNIV-----EPMVGLYEGSAEMSSDLHSLATFI 491
+T +TG Y N EP +G +A + I
Sbjct: 3634 HTDTTDRRQHTVTGLQPYTNYSFTLTACTSAGCTSSEPFLGQTLQAAPEGVWVTPRHIII 3693
Query: 492 YNSHPDKNFPARNRAEDQTSPVVTTRNQYITDI-AAEQLSYVIRRLVPFTEHMISVSAFT 550
++ + + + S +RN + + +E+ ++ + L P + + + T
Sbjct: 3694 NSTTVELYWSLPEKPNGLVSQYQLSRNGNLLFLGGSEEQNFTDKNLEPNSRYTYKLEVKT 3753
Query: 551 IMGEGPPTVLSVRTRQQVPSSI-KIINYKNISSSSILLYWDPPE--YPNGKITHYTIYAM 607
G V+T P I N I SI + W PP P + + +
Sbjct: 3754 GGGSSASDDYIVQTPMSTPEEIYPPYNITVIGPYSIFVAWIPPGILIPEIPVEYNVLLND 3813
Query: 608 ELDTNRAFQITTIDNSFLITGLKKYTKYKMRVAASTHVGESSLSEENDIFVRTSEDEPES 667
T AF + S L+ L +T+Y++R+ A + S + +FV+T PE+
Sbjct: 3814 GSVTPLAFSVGH-HQSTLLENLTPFTQYEIRIQACQN---GSCGVSSRMFVKT----PEA 3865
Query: 668 SPQDVE--VIDVTADE-IRLKWSPPEKPNGIIIAYEVL-----YKNIDTLYMKNTSTTDI 719
+P D+ V+ I +KW PPEKPNGIII Y + + L++ + +
Sbjct: 3866 APMDLNSPVLKALGSACIEIKWMPPEKPNGIIINYFIYRRPAGIEEESVLFVWSEGALEF 3925
Query: 720 ILR--NLRPHTLYNISVRSYTRFGHGNQVSSLLSVRTSETVPDSAPENITYKNISSGEIE 777
+ LRP TLY VR+ G + SL +T E P P + S+ +
Sbjct: 3926 MDEGDTLRPFTLYEYRVRACNSKGSVESLWSL--TQTLEAPPQDFPAPWA-QATSAHSVL 3982
Query: 778 LSFLPPSSPNGIIQKY-TIYLKR-------SNGNEERTINTTSLTQNIKVLKKYTQYIIE 829
L++ P SPNGII Y +Y +R S T+ TS ++ L+ +T Y I
Sbjct: 3983 LNWTKPESPNGIISHYRVVYQERPDDPTFNSPTVHAFTVKGTSHQAHLYGLEPFTTYRIG 4042
Query: 830 VSASTLKGEGVRSAPISILTEEDAPDSPPQDFSVKQL-SGVTVKLSWQPPLEPNGIILYY 888
V A+ GE + +P +++ ++ S ++F V+Q +G + L W P+ NG+I Y
Sbjct: 4043 VVAANHAGEIL--SPWTLIQTLESSPSGLRNFIVEQKENGRALLLQWSEPMRTNGVIKTY 4100
Query: 889 TVYVWNRSSLKTINVTETSLELSDLDYNVEYSAYVTASTRFGDGKTRSNIISFQTPEGAP 948
++ +N LD Y+ + A TR G + + + AP
Sbjct: 4101 NIFSDGFLEYSGLN---RQFLFRRLDPFTLYTLTLEACTRAGCAHSAPQPL---WTDEAP 4154
Query: 949 SDPPKDVYYANLSSSSIILFWTPPSKPNGIIQYYSVYYRNTSGTFMQNFTLHE----VTN 1004
D ++ S+S+ L W+ P PNG I Y V R G N T+ V
Sbjct: 4155 PDSQLAPTVHSVKSTSVELSWSEPVNPNGKIIRYEVIRRCFEGKAWGNQTIQADEKIVFT 4214
Query: 1005 DFDN-----MTVSTIIDKLTIFSYYTF-WLTASTSVGNGNKSSDIIEVYTDQDIPEGFVG 1058
+++ M T + T Y + W +A G+ S V T Q PEG
Sbjct: 4215 EYNTERNTFMYNDTGLQPWTQCEYKIYTWNSA------GHTCSSWNVVRTLQAPPEGLSP 4268
Query: 1059 N-LTYESISSTAINVSWVPPAQPNGLV-FYYVSLILQQTPRHVRPPLVTYERSIYFDNLE 1116
++Y S++ + +SW+PP Q NG++ Y + P P Y + L
Sbjct: 4269 PVISYVSMNPQKLLISWIPPEQSNGIIQSYRLQRNEMLYPFSFDPVTFNYTD----EELL 4324
Query: 1117 KYTDYILKITPSTEKGFSDTYTAQLYIKTEEDVP-ETSPIINTFKNLSSTSVLLSWDPPV 1175
++ Y + T G S + I T E P E SP +S+T + + W PP
Sbjct: 4325 PFSTYSYALQACTSGGCSTSKPTS--ITTLEAAPSEVSP--PDLWAVSATQMNVCWSPPT 4380
Query: 1176 KPNGAIISYDLTLQGPNENYSFITSDNYIILEELSPFTLYSFFAAARTRKGLGPSSILFF 1235
NG I Y L + S +++ L P++ Y+F A T G S
Sbjct: 4381 VQNGKITKY---LVRYDNKESLAGQGLCLLVSHLQPYSQYNFSLVACTNGGCTASVSKSA 4437
Query: 1236 YTDESVPLAPPQNLTLINCTSDFVWLKWSPSPLPGGIVKVYSFKIHEHETDTIYYKNISG 1295
+T E++P + TL S+ + + W P P G ++ Y + TI Y +G
Sbjct: 4438 WTMEALP-ENMDSPTLQVTGSESIEITWKPPRNPNGQIRSYELR----RDGTIVY---TG 4489
Query: 1296 FKTEAKLVGLEPVSTYSIRVSAFTKVGNGNQFSNVVKFTTQESVPDVVQNMQCMATSWQS 1355
+T + L P YS V+A G S +VK T S P ++ + A Q
Sbjct: 4490 LETRYRDFTLTPGVEYSYTVTASN--SQGGILSPLVKDRTSPSAPSGMEPPKLQARGPQE 4547
Query: 1356 VLVKWDPPKKANGIITQYMVTVER-----------NSTKVSPQDHMYTFIKLLANTSYVF 1404
+LV WDPP + NG I Y + + N+T S Y +L Y
Sbjct: 4548 ILVNWDPPVRTNGDIINYTLFIRELFERETKIIHINTTHNSFGMQSYIVNQLKPFHRYEI 4607
Query: 1405 KVRASTSAGEGDE-----STCHVSTLPETVPSVPTNIAFSDVQSTSATLTW---IRPDTI 1456
+++A T+ G T ++ L + P + +A Q T +L W ++P+
Sbjct: 4608 RIQACTTLGCASSDWTFIQTPEIAPLMQPPPHLEVQMAPGGFQPT-VSLLWTGPLQPNGK 4666
Query: 1457 LGYFQNYK--ITTQLRAQKCKEWESEECVEYQKIQYLYEAHLTEETVYGLKKFRWYRFQV 1514
+ Y++ Y+ I TQ R +Y T L F Y +QV
Sbjct: 4667 VLYYELYRRQIATQPRK--------------SNPVLIYNGSSTSFIDSELLPFTEYEYQV 4712
Query: 1515 AASTNAGYGNASNWISTKTLPGPPDG-PPENVHVVATSPFSISISWSEPAVITG-PTCYL 1572
A +AG S+W +T P PP+G HV++++ ++I S P G + Y
Sbjct: 4713 WAVNSAGKA-PSSWTWCRTGPAPPEGLRAPTFHVISSTQAVVNI--SAPGKPNGIVSLYR 4769
Query: 1573 IDVKSVDNDEFNISFIKSNEENKTIEIKDLEIFTRYSVVITAFTGNISAAYVEGKSSAEM 1632
+ S E +S + ++ + L+ FT YS+ + A T ++
Sbjct: 4770 LFSSSAHGAETVLSEGMATQQT----LHGLQAFTNYSIGVEACTC--------FNCCSKG 4817
Query: 1633 IVTTLESAPKDPPNNMTFQKIPDEVTK-FQLTFLPPSQPNGNIQVYQALVYREDDPTAVQ 1691
L + P PP+ ++ +I ++ + PP PNG I Y+ + P +
Sbjct: 4818 PTAELRTHPA-PPSGLSSPQIGTLASRTASFRWSPPMFPNGVIHSYELQFHVACPPDSAL 4876
Query: 1692 IHNLSIIQKTNTFV--IAMLEGLKGGHTYNISVYAVNSAGA 1730
S I+ T + A L GL+ TY + V A N G+
Sbjct: 4877 PCTPSQIETKYTGLGQKASLGGLQPYTTYKLRVVAHNEVGS 4917
Score = 231 bits (590), Expect = 5e-60
Identities = 282/1108 (25%), Positives = 460/1108 (41%), Gaps = 126/1108 (11%)
Query: 707 DTLYMKNTSTTDIILRNLRPHTLYNISVRSYTRFGHGNQVSSLLSVRTSETVPDS-APEN 765
+T++ + +T NL+P+ Y + ++ +G G +S + RT E VP +P
Sbjct: 3449 ETIHTGSVNTYSYTDVNLKPYMTYEYRISAWNSYGRG--LSKAVRARTKEDVPQGVSPPT 3506
Query: 766 ITYKNISSGEIELSFLPPSSPNGIIQKYTIYLKRSNGNEERTINTTSLTQNIKV-LKKYT 824
T + I L++ P NG I Y+ NG E TSL+ + K ++ +
Sbjct: 3507 WTKIDNLEDTIVLNWRKPIQSNGPI---IYYILLRNGIER--FRGTSLSFSDKEGIQPFQ 3561
Query: 825 QYIIEVSASTLKGEGVRSAPISILTEEDAPDS--PPQDFSVKQLSGVTVKLSWQPPLEPN 882
+Y ++ A T+ G S+ + T + P+S PP S+ LS V + LSW P + N
Sbjct: 3562 EYSYQLKACTVAG-CATSSKVVAATTQGVPESILPP---SITALSAVALHLSWSVPEKSN 3617
Query: 883 GIILYYTVYVWNRSSLKTINVTETSLELSDLDYNVEYSAYVTASTRFGDGKTRSNIISFQ 942
G+I Y + + + T ++ L YS +TA T G T S Q
Sbjct: 3618 GVIKEYQIRQVGKGLIHTDTTDRRQHTVTGLQPYTNYSFTLTACT--SAGCTSSEPFLGQ 3675
Query: 943 TPEGAPSDPPKDVYYANLSSSSIILFWTPPSKPNGIIQYYSVYYRNT----SGTFMQNFT 998
T + AP + ++S+++ L+W+ P KPNG++ Y + G+ QNFT
Sbjct: 3676 TLQAAPEGVWVTPRHIIINSTTVELYWSLPEKPNGLVSQYQLSRNGNLLFLGGSEEQNFT 3735
Query: 999 LHEVTNDFDNMTVSTIIDK-LTIFSYYTFWLTASTSVGNGNKSSDIIEVYTDQDIPEGFV 1057
DK L S YT+ L T G G+ +SD V T PE
Sbjct: 3736 -----------------DKNLEPNSRYTYKLEVKT--GGGSSASDDYIVQTPMSTPEEIY 3776
Query: 1058 GNLTYESISSTAINVSWVPPAQPNGLVFYYVSLILQQTPRHVRPPLVTYERSIYFDNLEK 1117
I +I V+W+PP + +++L V + +S +NL
Sbjct: 3777 PPYNITVIGPYSIFVAWIPPGILIPEIPVEYNVLLNDGSVTPLAFSVGHHQSTLLENLTP 3836
Query: 1118 YTDYILKITPSTEKGFSDTYTAQLYIKTEEDVPE--TSPIINTFKNLSSTSVLLSWDPPV 1175
+T Y ++I + + G S ++++++KT E P SP++ K L S + + W PP
Sbjct: 3837 FTQYEIRI-QACQNG-SCGVSSRMFVKTPEAAPMDLNSPVL---KALGSACIEIKWMPPE 3891
Query: 1176 KPNGAIISYDLTLQG---PNENYSFITSDNYIIL----EELSPFTLYSFFAAARTRKGLG 1228
KPNG II+Y + + E+ F+ S+ + + L PFTLY + A KG
Sbjct: 3892 KPNGIIINYFIYRRPAGIEEESVLFVWSEGALEFMDEGDTLRPFTLYEYRVRACNSKG-- 3949
Query: 1229 PSSILFFYTDESVPLAPPQNLTL--INCTS-DFVWLKWSPSPLPGGIVKVYSFKIHEHET 1285
S+ ++ APPQ+ TS V L W+ P GI+ Y E
Sbjct: 3950 --SVESLWSLTQTLEAPPQDFPAPWAQATSAHSVLLNWTKPESPNGIISHYRVVYQERPD 4007
Query: 1286 D------TIYYKNISGFKTEAKLVGLEPVSTYSIRVSAFTKVGNGNQFSNVVKFTTQESV 1339
D T++ + G +A L GLEP +TY I V A G S T ES
Sbjct: 4008 DPTFNSPTVHAFTVKGTSHQAHLYGLEPFTTYRIGVVAANHA--GEILSPWTLIQTLESS 4065
Query: 1340 PDVVQNMQC-MATSWQSVLVKWDPPKKANGIITQYMVTVERNSTKVSPQDHMYTFIKLLA 1398
P ++N + +++L++W P + NG+I Y + + + S + + F +L
Sbjct: 4066 PSGLRNFIVEQKENGRALLLQWSEPMRTNGVIKTYNIFSD-GFLEYSGLNRQFLFRRLDP 4124
Query: 1399 NTSYVFKVRASTSAGEGDESTCHVSTLPETVPSVPTNIAFSDVQSTSATLTWIRPDTILG 1458
T Y + A T AG + + T E P V+STS L+W P G
Sbjct: 4125 FTLYTLTLEACTRAGCAHSAPQPLWT-DEAPPDSQLAPTVHSVKSTSVELSWSEPVNPNG 4183
Query: 1459 YFQNYKITTQLRAQKCKEWESEECVEYQKIQYLYEAHLTEETVY-----GLKKFRWYRFQ 1513
Y++ R + K W ++ +KI ++ + TE + GL+ + ++
Sbjct: 4184 KIIRYEVIR--RCFEGKAWGNQTIQADEKI--VFTEYNTERNTFMYNDTGLQPWTQCEYK 4239
Query: 1514 VAASTNAGYGNASNWISTKTLPGPPDG-PPENVHVVATSPFSISISWSEPAVITGPTCYL 1572
+ +AG+ S+W +TL PP+G P + V+ +P + ISW P G +
Sbjct: 4240 IYTWNSAGH-TCSSWNVVRTLQAPPEGLSPPVISYVSMNPQKLLISWIPPEQSNG----I 4294
Query: 1573 IDVKSVDNDEFNISFIKSNEENKTIEIKDLEI--FTRYSVVITAFT-GNISAAYVEGKSS 1629
I + +E F + + T D E+ F+ YS + A T G S +S
Sbjct: 4295 IQSYRLQRNEMLYPF---SFDPVTFNYTDEELLPFSTYSYALQACTSGGCS-------TS 4344
Query: 1630 AEMIVTTLESAPKD--PPNNMTFQKIPDEVTKFQLTFLPPSQPNGNIQVYQALVYREDDP 1687
+TTLE+AP + PP+ T+ + + PP+ NG I Y + R D+
Sbjct: 4345 KPTSITTLEAAPSEVSPPDLWAV-----SATQMNVCWSPPTVQNGKITKY---LVRYDNK 4396
Query: 1688 TAVQIHNLSIIQKTNTFVIAMLEGLKGGHTYNISVYAVNSAGAGPKVPMRI-TMDIKAPA 1746
++ L + ++ L+ YN S+ A + G V TM+ A
Sbjct: 4397 ESLAGQGLCL----------LVSHLQPYSQYNFSLVACTNGGCTASVSKSAWTME----A 4442
Query: 1747 RPKTKPTPIYDATGKLLVTSTTITIRMP 1774
P+ +P TG + T R P
Sbjct: 4443 LPENMDSPTLQVTGSESIEITWKPPRNP 4470
Score = 219 bits (558), Expect = 2e-56
Identities = 303/1227 (24%), Positives = 501/1227 (40%), Gaps = 121/1227 (9%)
Query: 536 LVPFTEHMISVSAFTIMGEGPPTVLSVRTRQQVPSSIKIIN-YKNISSSSILLYWDPPEY 594
L PFTE++ V A G RT P S+ + ++++ SI + WD P
Sbjct: 1921 LQPFTEYLYRVIASHEGGSVYSDWSRGRTTGAAPQSVPTPSRVRSLNGYSIEVTWDEPVV 1980
Query: 595 PNGKITHYTIYAMELDTNRAFQITTIDNSF--------LITGLKKYTKYKMRVAASTHVG 646
G I Y + A D+ R ++ + F ++TGL + Y + + A T G
Sbjct: 1981 -RGVIEKYILKAYSEDSTRPPRMPSASAEFVNTSNLTGILTGLLPFKNYAVTLTACTLAG 2039
Query: 647 ESSLSEENDIFVRTSEDEPESSPQDVE--VIDVTADEIRLKWSPPEKPNGIIIAYEVLYK 704
+ S +I P+ +PQ+V+ V + L W+PP+K NGII Y LY
Sbjct: 2040 CTESSHALNI------STPQEAPQEVQPPVAKSLPSSLLLSWNPPKKANGIITQY-CLYM 2092
Query: 705 NIDTLYMKNTSTTDIILRNLRPHTLYNISVRSYTRFGHGNQVSSLLSVRTSETVPDSAPE 764
+ +Y + S + + +L T + + + T G N SS + + T++ P+
Sbjct: 2093 DGRLIY--SGSEENYTVTDLAVFTPHQFLLSACTHVGCTN--SSWVLLYTAQLPPEHVDS 2148
Query: 765 NITYKNISSGEIELSFLPPSSPNGIIQKYTIYLKRSNGNEERTI-----NTTSLTQN--I 817
+ + S I + + P +GI+++Y +Y+ SN + TI N+T L Q+ +
Sbjct: 2149 PVLTV-LDSRTIHIQWKQPRKISGILERYVLYM--SNHTHDFTIWSVIYNSTELFQDHML 2205
Query: 818 KVLKKYTQYIIEVSASTLKGEGVRSAPISILTEEDAPDSPPQDFSVKQLSGVTVKLSWQP 877
+ + +Y+I++ A T G V A LT+ED P+ P S + +SW
Sbjct: 2206 QYVLPGNKYLIKLGACTGGGCTVSEAS-EALTDEDIPEGVPAP-KAHSYSPDSFNVSWTE 2263
Query: 878 PLEPNGIILYYTVYVWNRSSLKTINVTETSLELSDLDYNVEYSAYVTASTRFGDGKTRSN 937
P PNG+I Y +Y+ + N +E S +S V A T G
Sbjct: 2264 PEYPNGVITSYGLYL---DGILIHNSSELSYRAYGFAPWSLHSFRVQACT--AKGCALGP 2318
Query: 938 IISFQTPEGAPSDPPKDVYYANLSSSSIILFWTPPSKPNGIIQ----YYSVYYRNTSGTF 993
++ +T E AP + +V+ S + W P +PNG++ + ++Y + G
Sbjct: 2319 LVENRTLE-APPEGTVNVFVKTQGSRKAHVRWEAPFRPNGLLTHSVLFTGIFYVDPVGN- 2376
Query: 994 MQNFTLHEVTNDF---DNMTVSTIIDKLTIFSYYTFWLTASTSVGNGNKSSDIIEVYTDQ 1050
N+TL VT + + +ID L F+ YT + S S G+ +D I +
Sbjct: 2377 --NYTLLNVTKVMYSGEETNLWVLIDGLVPFTNYTVQVNISNS--QGSLITDPITIAMPP 2432
Query: 1051 DIPEGFVGNLTYESISSTAINVSWVPPAQPN--GLVFYYVSLILQQTPRHVRPPLVTYER 1108
P+G + S + T++ V W PA+ N G Y + + +
Sbjct: 2433 GAPDGVLPP-RLSSATPTSLQVVWSTPARNNAPGSPRYQLQMRSGDSTHGFLELFSNPSA 2491
Query: 1109 SIYFD--NLEKYTDYILKITPSTEKGFSDTYTAQLYIKTEEDVPETSPIINTFK-NLSST 1165
S+ ++ +L+ YT+Y+ ++ S GF +++ + T ED P P++ ++ S
Sbjct: 2492 SLSYEVSDLQPYTEYMFRLVASN--GFGSAHSSWIPFMTAEDKP--GPVVPPILLDVKSR 2547
Query: 1166 SVLLSWDPPVKPNGAIISYDLTLQGPNENYSFITSDNYIILEELSPFTLYSFFAAARTRK 1225
+L++W P K NG I Y++ L G + N ++ L P+T Y F A T K
Sbjct: 2548 MMLVTWQHPRKSNGVITHYNIYLHGRLYLRTPGNVTNCTVMH-LHPYTAYKFQVEACTSK 2606
Query: 1226 G--LGPSSILFFYTDESVPLAPP--QNLTLINCTSDFVWLKWSPSPLPGGIVKVYSF--- 1278
G L P S T ++P AP + L + T V + W P P G+V+ ++
Sbjct: 2607 GCSLSPES----QTVWTLPGAPEGIPSPELFSDTPTSVIISWQPPTHPNGLVENFTIERR 2662
Query: 1279 -KIHEHETDTIYYKNISGFKTEAKLVGLEPVSTYSIRVSAFTKVGNGNQFSNVVKFTTQE 1337
K E T + + K L P + Y RV T G N S V+ TT+
Sbjct: 2663 VKGKEEVTTLVTLPRSHSMRFIDKTSALSPWTKYEYRVLMSTLHGGTNS-SAWVEVTTRP 2721
Query: 1338 SVPDVVQNMQCMATSWQSVLVKWDPPKKANGIITQYMVTVER---NSTKVSPQDHMYTFI 1394
S P VQ +V V W PP NG I Y + + T V+
Sbjct: 2722 SRPAGVQPPVVTVLEPDAVQVTWKPPLIQNGDILSYEIHMPDPHITLTNVTSAVLSQKVT 2781
Query: 1395 KLLANTSYVFKVRASTSAGEGDESTCHVS--TLPETVPSVPTNIAFSDVQSTSAT---LT 1449
L+ T+Y + A S G G C S T T P+VP N+ V S + ++
Sbjct: 2782 HLIPFTNYSVTIVAC-SGGNGYLGGCTESLPTYVTTHPTVPQNVGPLSVIPLSESYVVIS 2840
Query: 1450 WIRPDTILGYFQNYKITTQLRAQKCKEWESEECVEYQKI----QYLYEAHLTEETVYGLK 1505
W P G Y++ + Q E+ + I Q+LYE GL
Sbjct: 2841 WQPPSKPNGPNLRYELLRRKIQQPLASNPPEDLNRWHNIYSGTQWLYEDK-------GLS 2893
Query: 1506 KFRWYRFQVAASTNAGYGNASNWISTKTLPGPPDGPPENVHVVATSPFSISISWSEPAV- 1564
+F Y + + + G+ S ++ TL G P+ N+ + +I + W++P V
Sbjct: 2894 RFTTYEYMLFVHNSVGF-TPSREVTVTTLAGLPERGA-NLTASVLNHTAIDVRWAKPTVQ 2951
Query: 1565 -ITGPTCY--LIDVKSVDNDEFNISFIKSNEENKTIEIKDLEIFTRYSVVITAFTGNISA 1621
+ G Y L + ND I + + I L+ T Y + I+ F G
Sbjct: 2952 DLQGEVEYYTLFWSSATSNDSLKIL-----PDVNSHVIGHLKPNTEYWIFISVFNG---- 3002
Query: 1622 AYVEGKSSAEMIVTTLESAPKD--PPNNMTFQKIPDEVTKFQLTFLPPSQPNGNIQVYQA 1679
V +SA + TT + P+ PP + T ++ + PS PNG + Y
Sbjct: 3003 --VHSINSAGLHATTCDGEPQGMLPPEVVIINS-----TAVRVIWTSPSNPNGVVTEYSI 3055
Query: 1680 LVYREDDPTAVQIHNLSIIQKTNTFVI 1706
V + T + + I++ + F I
Sbjct: 3056 YVNNKLYKTGMNVPGSFILRDLSPFTI 3082
Score = 216 bits (549), Expect = 3e-55
Identities = 292/1226 (23%), Positives = 508/1226 (41%), Gaps = 158/1226 (12%)
Query: 524 IAAEQLSYVIRRLVPFTEHMISVSAFTIMGEGPPT-VLSVRTRQQVPSSIKIINYKNISS 582
+ L+ ++ L+PF + ++++A T+ G + L++ T Q+ P ++ K++ S
Sbjct: 2010 VNTSNLTGILTGLLPFKNYAVTLTACTLAGCTESSHALNISTPQEAPQEVQPPVAKSLPS 2069
Query: 583 SSILLYWDPPEYPNGKITHYTIYAMELDTNRAFQITTIDNSFLITGLKKYTKYKMRVAAS 642
S +LL W+PP+ NG IT Y +Y +D + + + ++ +T L +T ++ ++A
Sbjct: 2070 S-LLLSWNPPKKANGIITQYCLY---MDGRLIY--SGSEENYTVTDLAVFTPHQFLLSAC 2123
Query: 643 THVGESSLSEENDIFVRTSEDEPESSPQDVEVIDVTADEIRLKWSPPEKPNGIIIAYEVL 702
THVG + + + + T++ PE V + + + I ++W P K +GI+ Y VL
Sbjct: 2124 THVG---CTNSSWVLLYTAQLPPEHVDSPVLTV-LDSRTIHIQWKQPRKISGILERY-VL 2178
Query: 703 YKNIDT--------LYMKNTSTTDIILRNLRPHTLYNISVRSYTRFGHGNQVSSLLSVRT 754
Y + T +Y D +L+ + P Y I + + T G G VS T
Sbjct: 2179 YMSNHTHDFTIWSVIYNSTELFQDHMLQYVLPGNKYLIKLGACT--GGGCTVSEASEALT 2236
Query: 755 SETVPDSAPENITYKNISSGEIELSFLPPSSPNGIIQKYTIYLKRSNGNEERTINTTSLT 814
E +P+ P + + S +S+ P PNG+I Y +YL + N++ L+
Sbjct: 2237 DEDIPEGVPAPKAH-SYSPDSFNVSWTEPEYPNGVITSYGLYL-----DGILIHNSSELS 2290
Query: 815 QNIKVLKKYTQYIIEVSASTLKGEGVRSAPISILTEEDAPDSPPQ---DFSVKQLSGVTV 871
++ + V A T KG + L E ++PP+ + VK
Sbjct: 2291 YRAYGFAPWSLHSFRVQACTAKG-----CALGPLVENRTLEAPPEGTVNVFVKTQGSRKA 2345
Query: 872 KLSWQPPLEPNGII--------LYYTVYVWNRSSLKTINVTETSLELSDL----DYNVEY 919
+ W+ P PNG++ ++Y V N +L + S E ++L D V +
Sbjct: 2346 HVRWEAPFRPNGLLTHSVLFTGIFYVDPVGNNYTLLNVTKVMYSGEETNLWVLIDGLVPF 2405
Query: 920 SAY-VTASTRFGDGKTRSNIISFQTPEGAPSD--PPKDVYYANLSSSSIILFWTPPSKPN 976
+ Y V + G ++ I+ P GAP PP+ ++ + +S+ + W+ P++ N
Sbjct: 2406 TNYTVQVNISNSQGSLITDPITIAMPPGAPDGVLPPR---LSSATPTSLQVVWSTPARNN 2462
Query: 977 GI-IQYYSVYYRNTSGTFMQNFTLHEVTNDFDN--MTVSTIIDKLTIFSYYTFWLTASTS 1033
Y + R+ T H F N ++S + L ++ Y F L AS
Sbjct: 2463 APGSPRYQLQMRSGDST-------HGFLELFSNPSASLSYEVSDLQPYTEYMFRLVASN- 2514
Query: 1034 VGNGNKSSDIIEVYTDQDIPEGFVGNLTYESISSTAINVSWVPPAQPNGLVFYY----VS 1089
G G+ S I T +D P V + + + S + V+W P + NG++ +Y
Sbjct: 2515 -GFGSAHSSWIPFMTAEDKPGPVVPPILLD-VKSRMMLVTWQHPRKSNGVITHYNIYLHG 2572
Query: 1090 LILQQTPRHVRPPLVTYERSIYFDNLEKYTDYILKITPSTEKGFSDTYTAQLYIKTEEDV 1149
+ +TP +V V + L YT Y ++ T KG S + +Q + T
Sbjct: 2573 RLYLRTPGNVTNCTVMH--------LHPYTAYKFQVEACTSKGCSLSPESQT-VWTLPGA 2623
Query: 1150 PETSPIINTFKNLSSTSVLLSWDPPVKPNGAIISYDL--TLQGPNENYSFIT---SDNYI 1204
PE P F + + TSV++SW PP PNG + ++ + ++G E + +T S +
Sbjct: 2624 PEGIPSPELFSD-TPTSVIISWQPPTHPNGLVENFTIERRVKGKEEVTTLVTLPRSHSMR 2682
Query: 1205 ILEE---LSPFTLYSFFAAARTRKGLGPSSILFFYTDESVPLAPPQNLTLINCTSDFVWL 1261
+++ LSP+T Y + T G SS T A Q + D V +
Sbjct: 2683 FIDKTSALSPWTKYEYRVLMSTLHGGTNSSAWVEVTTRPSRPAGVQPPVVTVLEPDAVQV 2742
Query: 1262 KWSPSPLPGGIVKVYSFKIHEHETDTIYYKNISGFKTEAKLVGLEPVSTYSIRVSAFTKV 1321
W P + G + S++IH + I N++ K+ L P + YS+ + A +
Sbjct: 2743 TWKPPLIQNG--DILSYEIHMPDPH-ITLTNVTSAVLSQKVTHLIPFTNYSVTIVACSG- 2798
Query: 1322 GNGN----QFSNVVKFTTQESVPDVVQNMQCMATSWQSVLVKWDPPKKANGIITQYMV-- 1375
GNG S TT +VP V + + S V++ W PP K NG +Y +
Sbjct: 2799 GNGYLGGCTESLPTYVTTHPTVPQNVGPLSVIPLSESYVVISWQPPSKPNGPNLRYELLR 2858
Query: 1376 -TVERNSTKVSPQD------------HMYTFIKLLANTSYVFKVRASTSAGEGDESTCHV 1422
+++ P+D +Y L T+Y + + S G V
Sbjct: 2859 RKIQQPLASNPPEDLNRWHNIYSGTQWLYEDKGLSRFTTYEYMLFVHNSVGFTPSREVTV 2918
Query: 1423 STLPETVPSVPTNIAFSDVQSTSATLTWIRP--DTILGYFQNYKITTQLRAQKCKEWESE 1480
+TL +P N+ S + T+ + W +P + G + Y + W S
Sbjct: 2919 TTL-AGLPERGANLTASVLNHTAIDVRWAKPTVQDLQGEVEYYTLF----------WSSA 2967
Query: 1481 ECVEYQKIQYLYEAHLTEETVYGLKKFRWYRFQVAASTNAGYGNASNWISTKTLPGPPDG 1540
+ KI +H+ + LK Y ++ N++ +T T G P G
Sbjct: 2968 TSNDSLKILPDVNSHV----IGHLKPNTEYWIFISVFNGVHSINSAGLHAT-TCDGEPQG 3022
Query: 1541 --PPENVHVVATSPFSISISWSEPA----VITGPTCYLIDVKSVDNDEFNISFIKSNEEN 1594
PPE VV + ++ + W+ P+ V+T + Y+ + SFI
Sbjct: 3023 MLPPE---VVIINSTAVRVIWTSPSNPNGVVTEYSIYVNNKLYKTGMNVPGSFI------ 3073
Query: 1595 KTIEIKDLEIFTRYSVVITAFTGNISAAYVEGKSSAEMIVTTLESAPKDPPNNMTFQKIP 1654
++DL FT Y + + + Y KS+ I TT+E P D P T + I
Sbjct: 3074 ----LRDLSPFTIYDIQV-----EVCTIYACVKSNGTQI-TTVEDTPSDIP-TPTIRGIT 3122
Query: 1655 DEVTKFQLTFLPPSQPNGNIQVYQAL 1680
Q+ ++ P +PNG I Y L
Sbjct: 3123 SR--SLQIDWVSPRKPNGIILGYDLL 3146
Score = 212 bits (540), Expect = 3e-54
Identities = 299/1309 (22%), Positives = 520/1309 (39%), Gaps = 147/1309 (11%)
Query: 273 LRPYTTYLFEVSAATTEAG--YIDSTIVRTPESVPEGPPQNCVTGNITGKSFSILWDPPT 330
L+P+T YL+ V A+ E G Y D + RT + P+ P ++ G S + WD P
Sbjct: 1921 LQPFTEYLYRV-IASHEGGSVYSDWSRGRTTGAAPQSVPTPSRVRSLNGYSIEVTWDEPV 1979
Query: 331 IVTGKFSYRVELYG---------PSGRILDNSTKDLKFAFTNLTPFTMYDVYIAAETSAG 381
+ Y ++ Y PS +T +L T L PF Y V + A T AG
Sbjct: 1980 VRGVIEKYILKAYSEDSTRPPRMPSASAEFVNTSNLTGILTGLLPFKNYAVTLTACTLAG 2039
Query: 382 TGPKSN-ISVFTPPDVPGAVFDLQLAEVESTQVRITWKKPRQPNGIINQYRVKVLVPETG 440
S+ +++ TP + P V +A+ + + ++W P++ NGII QY
Sbjct: 2040 CTESSHALNISTPQEAPQEV-QPPVAKSLPSSLLLSWNPPKKANGIITQY---------C 2089
Query: 441 IILENTLLTGNNEYINDPMAPEIVNIVEPMVGLYEGSAEMSSDLHSLATFIYNSHPDKNF 500
+ ++ L+ +E + + + P L + S P ++
Sbjct: 2090 LYMDGRLIYSGSE---ENYTVTDLAVFTPHQFLLSACTHVGCTNSSWVLLYTAQLPPEHV 2146
Query: 501 --PARNRAEDQTSPVVTTRNQYITDIAAEQLSYVIRRLVPFT------------------ 540
P + +T + + + I+ I + Y+ FT
Sbjct: 2147 DSPVLTVLDSRTIHIQWKQPRKISGILERYVLYMSNHTHDFTIWSVIYNSTELFQDHMLQ 2206
Query: 541 ------EHMISVSAFTIMGEGPPTVLSVRTRQQVPSSIKIINYKNISSSSILLYWDPPEY 594
+++I + A T G T + +P + + S S + W PEY
Sbjct: 2207 YVLPGNKYLIKLGACTGGGCTVSEASEALTDEDIPEGVPAPKAHSYSPDSFNVSWTEPEY 2266
Query: 595 PNGKITHYTIYAMELDTNRAFQITTIDNSFLITGLKKYTKYKMRVAASTHVG--ESSLSE 652
PNG IT Y +Y + + + ++ S+ G ++ + RV A T G L E
Sbjct: 2267 PNGVITSYGLYLDGILIHNSSEL-----SYRAYGFAPWSLHSFRVQACTAKGCALGPLVE 2321
Query: 653 ENDIFVRTSEDEPESSPQDVEVIDVTADEIRLKWSPPEKPNGIIIAYEVLYKNI------ 706
RT E PE + +V V + + ++W P +PNG ++ + VL+ I
Sbjct: 2322 N-----RTLEAPPEGT-VNVFVKTQGSRKAHVRWEAPFRPNG-LLTHSVLFTGIFYVDPV 2374
Query: 707 ----------DTLYMKNTSTTDIILRNLRPHTLYNISVRSYTRFGHGNQVSSLLSVRTSE 756
+Y + +++ L P T Y + V N SL++ +
Sbjct: 2375 GNNYTLLNVTKVMYSGEETNLWVLIDGLVPFTNYTVQVNI------SNSQGSLITDPITI 2428
Query: 757 TVPDSAPENITYKNISSG---EIELSFLPPSSPNGI-IQKYTIYLKRSNGN----EERTI 808
+P AP+ + +SS +++ + P+ N +Y + ++ + E +
Sbjct: 2429 AMPPGAPDGVLPPRLSSATPTSLQVVWSTPARNNAPGSPRYQLQMRSGDSTHGFLELFSN 2488
Query: 809 NTTSLTQNIKVLKKYTQYIIEVSASTLKGEGVRSAPISILTEEDAPDS--PPQDFSVKQL 866
+ SL+ + L+ YT+Y+ + AS G S+ I +T ED P PP VK
Sbjct: 2489 PSASLSYEVSDLQPYTEYMFRLVASNGFG-SAHSSWIPFMTAEDKPGPVVPPILLDVKSR 2547
Query: 867 SGVTVKLSWQPPLEPNGIILYYTVYVWNRSSLKTINVTETSLELSDLDYNVEYSAYVTAS 926
+ ++WQ P + NG+I +Y +Y+ R L+T T+ + L Y V A
Sbjct: 2548 ---MMLVTWQHPRKSNGVITHYNIYLHGRLYLRTPG-NVTNCTVMHLHPYTAYKFQVEAC 2603
Query: 927 TRFGDGKTRSNIISFQTPEGAPSDPPKDVYYANLSSSSIILFWTPPSKPNGIIQYYSVYY 986
T G + + + P GAP P +++ + +S+I+ W PP+ PNG+++ +++
Sbjct: 2604 TSKGCSLSPESQTVWTLP-GAPEGIPSPELFSD-TPTSVIISWQPPTHPNGLVENFTI-E 2660
Query: 987 RNTSGTFMQNFTLHEVTNDFDNMTVSTIIDKLTIFSYYTFWLTASTSVGNGNKSSDIIEV 1046
R G + T +M L+ ++ Y + + ST G G SS +EV
Sbjct: 2661 RRVKG--KEEVTTLVTLPRSHSMRFIDKTSALSPWTKYEYRVLMSTLHG-GTNSSAWVEV 2717
Query: 1047 YTDQDIPEGFVGNLTYESISSTAINVSWVPPAQPNGLVFYYVSLILQQTPRHVRPPLVTY 1106
T P G V + A+ V+W PP NG + Y I P + +
Sbjct: 2718 TTRPSRPAG-VQPPVVTVLEPDAVQVTWKPPLIQNGDILSYE--IHMPDPHITLTNVTSA 2774
Query: 1107 ERSIYFDNLEKYTDYILKITP-STEKGFSDTYTAQL--YIKTEEDVPETSPIINTFKNLS 1163
S +L +T+Y + I S G+ T L Y+ T VP+ ++ LS
Sbjct: 2775 VLSQKVTHLIPFTNYSVTIVACSGGNGYLGGCTESLPTYVTTHPTVPQNVGPLSVIP-LS 2833
Query: 1164 STSVLLSWDPPVKPNGAIISYDL---TLQGP---------NENYSFITSDNYIILEE-LS 1210
+ V++SW PP KPNG + Y+L +Q P N ++ + ++ ++ LS
Sbjct: 2834 ESYVVISWQPPSKPNGPNLRYELLRRKIQQPLASNPPEDLNRWHNIYSGTQWLYEDKGLS 2893
Query: 1211 PFTLYSFFAAARTRKGLGPSSILFFYTDESVPLAPPQNLT--LINCTS-DFVWLKWSPSP 1267
FT Y + G PS + T +P NLT ++N T+ D W K +
Sbjct: 2894 RFTTYEYMLFVHNSVGFTPSREVTVTTLAGLP-ERGANLTASVLNHTAIDVRWAKPTVQD 2952
Query: 1268 LPGGIVKVYSFKIHEHETDTIYYKNISGFKTEAKLVG-LEPVSTYSIRVSAFTKVGNGNQ 1326
L G + F D++ + ++G L+P + Y I +S F V + N
Sbjct: 2953 LQGEVEYYTLFWSSATSNDSLKILP----DVNSHVIGHLKPNTEYWIFISVFNGVHSIN- 3007
Query: 1327 FSNVVKFTTQESVPDVVQNMQCMATSWQSVLVKWDPPKKANGIITQYMVTVERNSTKVSP 1386
S + TT + P + + + + +V V W P NG++T+Y + V K
Sbjct: 3008 -SAGLHATTCDGEPQGMLPPEVVIINSTAVRVIWTSPSNPNGVVTEYSIYVNNKLYKTGM 3066
Query: 1387 Q-DHMYTFIKLLANTSYVFKVRASTSAGEGDESTCHVSTLPETVPSVPTNIAFSDVQSTS 1445
+ L T Y +V T + ++T+ +T +PT + S S
Sbjct: 3067 NVPGSFILRDLSPFTIYDIQVEVCTIYACVKSNGTQITTVEDTPSDIPTP-TIRGITSRS 3125
Query: 1446 ATLTWIRP----DTILGYFQNYKITTQ-LRAQKCKEWESEECVEYQKIQ 1489
+ W+ P ILGY +K + QK + +S+E + + Q
Sbjct: 3126 LQIDWVSPRKPNGIILGYDLLWKTWYPCAKTQKLVQDQSDELCKAVRCQ 3174
Score = 204 bits (519), Expect = 8e-52
Identities = 249/1037 (24%), Positives = 429/1037 (41%), Gaps = 99/1037 (9%)
Query: 753 RTSETVPDSAPENITYKNISSGEIELSFLPPSSPNGIIQKYTIYL--------KRSNGNE 804
RT+ P S P ++++ IE+++ P G+I+KY + R
Sbjct: 1948 RTTGAAPQSVPTPSRVRSLNGYSIEVTWDEPVV-RGVIEKYILKAYSEDSTRPPRMPSAS 2006
Query: 805 ERTINTTSLTQNIKVLKKYTQYIIEVSASTLKGEGVRSAPISILTEEDAPDS--PPQDFS 862
+NT++LT + L + Y + ++A TL G S ++I T ++AP PP S
Sbjct: 2007 AEFVNTSNLTGILTGLLPFKNYAVTLTACTLAGCTESSHALNISTPQEAPQEVQPPVAKS 2066
Query: 863 VKQLSGVTVKLSWQPPLEPNGIILYYTVYVWNRSSLKTINVTETSLELSDLDYNVEYSAY 922
+ ++ LSW PP + NGII Y +Y+ R + +E + ++DL +
Sbjct: 2067 LPS----SLLLSWNPPKKANGIITQYCLYMDGRL---IYSGSEENYTVTDLAVFTPHQFL 2119
Query: 923 VTASTRFGDGKTRSNIISFQTPEGAPSDPPKDVYYANLSSSSIILFWTPPSKPNGIIQYY 982
++A T G T S+ + T + P V L S +I + W P K +GI++ Y
Sbjct: 2120 LSACTHVGC--TNSSWVLLYTAQLPPEHVDSPVLTV-LDSRTIHIQWKQPRKISGILERY 2176
Query: 983 SVYYRNTSGTFMQNFTLHEVTNDFDNMTVSTIIDKLTIFSYYTFWLTASTSVGNGNKSSD 1042
+Y N + +FT+ V + + ++ + + Y L A T G G S+
Sbjct: 2177 VLYMSNHT----HDFTIWSVIYNSTELFQDHMLQYVLPGNKYLIKLGACT--GGGCTVSE 2230
Query: 1043 IIEVYTDQDIPEGFVGNLTYESISSTAINVSWVPPAQPNGLVFYYVSLILQQTPRHVRPP 1102
E TD+DIPEG + S S + NVSW P PNG++ Y L L H
Sbjct: 2231 ASEALTDEDIPEGVPAPKAH-SYSPDSFNVSWTEPEYPNGVITSY-GLYLDGILIHN--- 2285
Query: 1103 LVTYERSIYFDNLEKYTDYILKITPSTEKGFSDTYTAQLYIKTEEDVPETSPIINTF-KN 1161
+ E S ++ + ++ T KG + + +T E PE + +N F K
Sbjct: 2286 --SSELSYRAYGFAPWSLHSFRVQACTAKGCA--LGPLVENRTLEAPPEGT--VNVFVKT 2339
Query: 1162 LSSTSVLLSWDPPVKPNGAIISYDLTLQG------PNENYSFIT----------SDNYII 1205
S + W+ P +PNG ++++ + G NY+ + ++ +++
Sbjct: 2340 QGSRKAHVRWEAPFRPNG-LLTHSVLFTGIFYVDPVGNNYTLLNVTKVMYSGEETNLWVL 2398
Query: 1206 LEELSPFTLYSFFAAARTRKGLGPSSILFFYTDESVP--LAPPQNLTLINCTSDFVWLKW 1263
++ L PFT Y+ +G + + P + PP+ + + VW
Sbjct: 2399 IDGLVPFTNYTVQVNISNSQGSLITDPITIAMPPGAPDGVLPPRLSSATPTSLQVVWSTP 2458
Query: 1264 SPSPLPGGIVKVYSFKIHEHETDTIYYKNISGFKTEA--KLVGLEPVSTYSIRVSAFTKV 1321
+ + PG Y ++ ++ + + S ++ L+P + Y R+ A
Sbjct: 2459 ARNNAPGS--PRYQLQMRSGDSTHGFLELFSNPSASLSYEVSDLQPYTEYMFRLVASN-- 2514
Query: 1322 GNGNQFSNVVKFTTQESVPDVVQNMQCMATSWQSVLVKWDPPKKANGIITQYMVTVERNS 1381
G G+ S+ + F T E P V + + +LV W P+K+NG+IT Y + +
Sbjct: 2515 GFGSAHSSWIPFMTAEDKPGPVVPPILLDVKSRMMLVTWQHPRKSNGVITHYNIYLHGRL 2574
Query: 1382 TKVSPQDHMY-TFIKLLANTSYVFKVRASTSAGEG-DESTCHVSTLPETVPSVPTNIAFS 1439
+P + T + L T+Y F+V A TS G + V TLP +P+ FS
Sbjct: 2575 YLRTPGNVTNCTVMHLHPYTAYKFQVEACTSKGCSLSPESQTVWTLPGAPEGIPSPELFS 2634
Query: 1440 DVQSTSATLTWIRPDTILGYFQNYKITTQLRAQKCKEWESEECVEYQKIQYLYEAHLTEE 1499
D TS ++W P G +N+ I +++ + EE + + ++
Sbjct: 2635 DTP-TSVIISWQPPTHPNGLVENFTIERRVKGK-------EEVTTLVTLPRSHSMRFIDK 2686
Query: 1500 TVYGLKKFRWYRFQVAASTNAGYGNASNWISTKTLPGPPDGPPENVHVVATSPFSISISW 1559
T L + Y ++V ST G N+S W+ T P P G V V P ++ ++W
Sbjct: 2687 TS-ALSPWTKYEYRVLMSTLHGGTNSSAWVEVTTRPSRPAGVQPPV-VTVLEPDAVQVTW 2744
Query: 1560 SEPAVITGPTCYLIDVKS--VDNDEFNISFIKSNEENKTIEIKDLEIFTRYSVVITAFTG 1617
P + G D+ S + + +I+ + ++ L FT YSV I A +G
Sbjct: 2745 KPPLIQNG------DILSYEIHMPDPHITLTNVTSAVLSQKVTHLIPFTNYSVTIVACSG 2798
Query: 1618 NISAAYVEGKSSAEMIVTTLESAPKDPPNNMTFQKIPDEVTKFQLTFLPPSQPNGNIQVY 1677
Y+ G E + T + + P P N IP + +++ PPS+PNG Y
Sbjct: 2799 G--NGYLGG--CTESLPTYVTTHPTVPQNVGPLSVIPLSESYVVISWQPPSKPNGPNLRY 2854
Query: 1678 QALVYREDDPTAV-------QIHNLSIIQKTNTFVIAMLEGLKGGHTYNISVYAVNSAGA 1730
+ L + P A + HN+ + T + +GL TY ++ NS G
Sbjct: 2855 ELLRRKIQQPLASNPPEDLNRWHNI----YSGTQWLYEDKGLSRFTTYEYMLFVHNSVGF 2910
Query: 1731 GPKVPMRITMDIKAPAR 1747
P + +T P R
Sbjct: 2911 TPSREVTVTTLAGLPER 2927
Score = 190 bits (483), Expect = 1e-47
Identities = 290/1196 (24%), Positives = 474/1196 (39%), Gaps = 169/1196 (14%)
Query: 623 SFLITGLKKYTKYKMRVAASTHVGESSLSEENDIFVRTSEDEPES-SPQDVEVIDVTADE 681
S+ LK Y Y+ R++A G LS+ + RT ED P+ SP ID D
Sbjct: 3460 SYTDVNLKPYMTYEYRISAWNSYGRG-LSKA--VRARTKEDVPQGVSPPTWTKIDNLEDT 3516
Query: 682 IRLKWSPPEKPNGIIIAYEVLYKNIDTLYMKNTSTTDIILRNLRPHTLYNISVRSYTRFG 741
I L W P + NG II Y +L I+ + TS + ++P Y+ +++ T G
Sbjct: 3517 IVLNWRKPIQSNGPIIYYILLRNGIER--FRGTSLSFSDKEGIQPFQEYSYQLKACTVAG 3574
Query: 742 HGNQVSSLLSVRTSETVPDS-APENITYKNISSGEIELSFLPPSSPNGIIQKYTIYLKRS 800
SS + T++ VP+S P +IT +S+ + LS+ P NG+I++Y I R
Sbjct: 3575 CA--TSSKVVAATTQGVPESILPPSIT--ALSAVALHLSWSVPEKSNGVIKEYQI---RQ 3627
Query: 801 NGNEERTINTTSLTQN-IKVLKKYTQYIIEVSASTLKGEGVRSAPISILTEEDAPDSPPQ 859
G +TT Q+ + L+ YT Y ++A T G S P T + AP+
Sbjct: 3628 VGKGLIHTDTTDRRQHTVTGLQPYTNYSFTLTACTSAG-CTSSEPFLGQTLQAAPEGVWV 3686
Query: 860 DFSVKQLSGVTVKLSWQPPLEPNGIILYYTVYVWNRSSLKTINVTETSLELSDLDYNVEY 919
++ TV+L W P +PNG++ Y + N + L E + +L+ N Y
Sbjct: 3687 TPRHIIINSTTVELYWSLPEKPNGLVSQYQL-SRNGNLLFLGGSEEQNFTDKNLEPNSRY 3745
Query: 920 SAYVTASTRFGDGKTRSNIISFQTPEGAPSD--PPKDVYYANLSSSSIILFWTPPSKPNG 977
+ + T G G + S+ QTP P + PP ++ + SI + W PP G
Sbjct: 3746 TYKLEVKT--GGGSSASDDYIVQTPMSTPEEIYPPYNI--TVIGPYSIFVAWIPP----G 3797
Query: 978 II-----QYYSVYYRNTSGTFMQNFTLHEVTNDFDNMTVSTIIDKLTIFSYYTFWLTAST 1032
I+ Y+V + S T + H ST+++ LT F+ Y + A
Sbjct: 3798 ILIPEIPVEYNVLLNDGSVTPLAFSVGHH---------QSTLLENLTPFTQYEIRIQACQ 3848
Query: 1033 SVGNGNKSSDIIEVYTDQDIPEGFVGNLTYESISSTAINVSWVPPAQPNGLVFYYVSLIL 1092
+ G S ++ T + P + + +++ S I + W+PP +PNG++ Y +
Sbjct: 3849 NGSCGVSSRMFVK--TPEAAPMD-LNSPVLKALGSACIEIKWMPPEKPNGIIINY---FI 3902
Query: 1093 QQTPRHVRPPLVTY---ERSIYF----DNLEKYTDYILKITPSTEKGFSDTYTAQLYIKT 1145
+ P + V + E ++ F D L +T Y ++ KG ++ + +T
Sbjct: 3903 YRRPAGIEEESVLFVWSEGALEFMDEGDTLRPFTLYEYRVRACNSKGSVESLWS--LTQT 3960
Query: 1146 EEDVPETSPIINTFKNLSSTSVLLSWDPPVKPNGAIISYDLTLQGPNENYSFIT------ 1199
E P+ P + S+ SVLL+W P PNG I Y + Q ++ +F +
Sbjct: 3961 LEAPPQDFP-APWAQATSAHSVLLNWTKPESPNGIISHYRVVYQERPDDPTFNSPTVHAF 4019
Query: 1200 ----SDNYIILEELSPFTLYSFFAAARTRKGLGPSSILFFYTDESVPLAPPQNLTLINCT 1255
+ + L L PFT Y A G S T ES P +
Sbjct: 4020 TVKGTSHQAHLYGLEPFTTYRIGVVAANHAGEILSPWTLIQTLESSPSGLRNFIVEQKEN 4079
Query: 1256 SDFVWLKWSPSPLPGGIVKVYSFKIHEHETDTIYYKNISGFKTEAKLVGLEPVSTYSIRV 1315
+ L+WS G++K Y+ + + SG + L+P + Y++ +
Sbjct: 4080 GRALLLQWSEPMRTNGVIKTYNI-------FSDGFLEYSGLNRQFLFRRLDPFTLYTLTL 4132
Query: 1316 SAFTKVGNGNQFSNVVKFTTQESVPDVVQNMQCMATSWQSVLVKWDPPKKANGIITQYMV 1375
A T+ G + S T E+ PD + SV + W P NG I +Y V
Sbjct: 4133 EACTRAGCAH--SAPQPLWTDEAPPDSQLAPTVHSVKSTSVELSWSEPVNPNGKIIRYEV 4190
Query: 1376 -------------TVERNSTKVSPQ------DHMYTFIKLLANTSYVFKVRASTSAGEGD 1416
T++ + V + MY L T +K+ SAG
Sbjct: 4191 IRRCFEGKAWGNQTIQADEKIVFTEYNTERNTFMYNDTGLQPWTQCEYKIYTWNSAGHTC 4250
Query: 1417 ESTCHVSTL---PETVPSVPTNIAFSDVQSTSATLTWIRPDTILGYFQNYKITTQLRAQK 1473
S V TL PE + P I++ + ++WI P+ G Q+Y++
Sbjct: 4251 SSWNVVRTLQAPPEGLS--PPVISYVSMNPQKLLISWIPPEQSNGIIQSYRLQRN----- 4303
Query: 1474 CKEWESEECVEYQKIQYLYEAHLTEETVYGLKKFRWYRFQVAASTNAGYGNASNWISTKT 1533
E + + + Y T+E L F Y + + A T+ G + S S T
Sbjct: 4304 ----EMLYPFSFDPVTFNY----TDEE---LLPFSTYSYALQACTSGGC-STSKPTSITT 4351
Query: 1534 LPGPPD--GPPENVHVVATSPFSISISWSEPAVITGP-TCYLIDVKSVDNDEFNISFIKS 1590
L P PP+ + A S +++ WS P V G T YL+ DN E
Sbjct: 4352 LEAAPSEVSPPD---LWAVSATQMNVCWSPPTVQNGKITKYLV---RYDNKE------SL 4399
Query: 1591 NEENKTIEIKDLEIFTRYSVVITAFTGNISAAYVEGKSSAEMIVTTLESAPKDPPNNMTF 1650
+ + + L+ +++Y+ + A T A S T+E+ P++ ++ T
Sbjct: 4400 AGQGLCLLVSHLQPYSQYNFSLVACTNGGCTA------SVSKSAWTMEALPEN-MDSPTL 4452
Query: 1651 QKIPDEVTKFQLTFLPPSQPNGNIQVYQALVYREDDPTAVQIHNLSIIQKTNTFVIAMLE 1710
Q E ++T+ PP PNG I+ Y+ +++ T V LE
Sbjct: 4453 QVTGSE--SIEITWKPPRNPNGQIRSYE-------------------LRRDGTIVYTGLE 4491
Query: 1711 ------GLKGGHTYNISVYAVNSAGAGPKVPMRITMDIKAPARPKTKPTPIYDATG 1760
L G Y+ +V A NS G + + D +P+ P P A G
Sbjct: 4492 TRYRDFTLTPGVEYSYTVTASNSQGG---ILSPLVKDRTSPSAPSGMEPPKLQARG 4544
Score = 187 bits (476), Expect = 8e-47
Identities = 277/1188 (23%), Positives = 482/1188 (40%), Gaps = 145/1188 (12%)
Query: 269 VVTHLRPYTTYLFEVSAATTEAGYIDSTI---VRTPESVPEG--PPQNCVTGNITGKSFS 323
++T L P+ Y ++A T AG +S+ + TP+ P+ PP S
Sbjct: 2018 ILTGLLPFKNYAVTLTACTL-AGCTESSHALNISTPQEAPQEVQPP----VAKSLPSSLL 2072
Query: 324 ILWDPPTIVTGKFSYRVELYGPSGRILDNSTKDLKFAFTNLTPFTMYDVYIAAETSAGTG 383
+ W+PP G + LY GR++ + +++ + T+L FT + ++A T G
Sbjct: 2073 LSWNPPKKANGIITQYC-LY-MDGRLIYSGSEE-NYTVTDLAVFTPHQFLLSACTHVGCT 2129
Query: 384 PKSNISVFTPPDVPGAVFDLQLAEVESTQVRITWKKPRQPNGIINQYRVKVLVPETGIIL 443
S + ++T P V L ++S + I WK+PR+ +GI+ +Y V + T
Sbjct: 2130 NSSWVLLYTAQLPPEHVDSPVLTVLDSRTIHIQWKQPRKISGILERY-VLYMSNHTHDFT 2188
Query: 444 ENTLLTGNNEYINDPMAPEIVNIVEPMVGLYE---GSAEMSSDLHSL----------ATF 490
+++ + E D M ++ + ++ L G +S +L A
Sbjct: 2189 IWSVIYNSTELFQDHMLQYVLPGNKYLIKLGACTGGGCTVSEASEALTDEDIPEGVPAPK 2248
Query: 491 IYNSHPDKNFPARNRAEDQTSPVVTTRNQYITDIA---AEQLSYVIRRLVPFTEHMISVS 547
++ PD +F + + V+T+ Y+ I + +LSY P++ H V
Sbjct: 2249 AHSYSPD-SFNVSWTEPEYPNGVITSYGLYLDGILIHNSSELSYRAYGFAPWSLHSFRVQ 2307
Query: 548 AFTIMGEGPPTVLSVRTRQQVPSSIKIINYKNISSSSILLYWDPPEYPNGKITHYTIYAM 607
A T G ++ RT + P + K S + W+ P PNG +TH ++
Sbjct: 2308 ACTAKGCALGPLVENRTLEAPPEGTVNVFVKTQGSRKAHVRWEAPFRPNGLLTHSVLF-- 2365
Query: 608 ELDTNRAFQITTIDNSF-------------------LITGLKKYTKYKMRVAASTHVGES 648
F + + N++ LI GL +T Y ++V S G S
Sbjct: 2366 ----TGIFYVDPVGNNYTLLNVTKVMYSGEETNLWVLIDGLVPFTNYTVQVNISNSQG-S 2420
Query: 649 SLSEENDIFVRTSEDEPESSPQDV---EVIDVTADEIRLKWSPPEKPNGI-IIAYEVLYK 704
+++ I + P +P V + T +++ WS P + N Y++ +
Sbjct: 2421 LITDPITIAM------PPGAPDGVLPPRLSSATPTSLQVVWSTPARNNAPGSPRYQLQMR 2474
Query: 705 NIDT------LYMKNTSTTDIILRNLRPHTLYNISVRSYTRFGHGNQVSSLLSVRTSETV 758
+ D+ L+ +++ + +L+P+T Y R G G+ SS + T+E
Sbjct: 2475 SGDSTHGFLELFSNPSASLSYEVSDLQPYTEY--MFRLVASNGFGSAHSSWIPFMTAEDK 2532
Query: 759 PDSAPENITYKNISSGEIELSFLPPSSPNGIIQKYTIYLK-----RSNGNEERTINTTSL 813
P I ++ S + +++ P NG+I Y IYL R+ G N T+
Sbjct: 2533 PGPVVPPILL-DVKSRMMLVTWQHPRKSNGVITHYNIYLHGRLYLRTPG------NVTNC 2585
Query: 814 TQNIKVLKKYTQYIIEVSASTLKGEGVRSAPISILTEEDAPDSPPQDFSVKQLSGVTVKL 873
T + L YT Y +V A T KG + ++ T AP+ P + + +V +
Sbjct: 2586 T--VMHLHPYTAYKFQVEACTSKGCSLSPESQTVWTLPGAPEGIPSP-ELFSDTPTSVII 2642
Query: 874 SWQPPLEPNGIILYYTV--YVWNRSSLKTINVTETSLELSDLDYN------VEYSAYVTA 925
SWQPP PNG++ +T+ V + + T+ S + +D +Y V
Sbjct: 2643 SWQPPTHPNGLVENFTIERRVKGKEEVTTLVTLPRSHSMRFIDKTSALSPWTKYEYRVLM 2702
Query: 926 STRFGDGKTRSNIISFQTPEGAPSDPPKDVYYANLSSSSIILFWTPPSKPNGIIQYYSVY 985
ST G G S + T P+ V L ++ + W PP NG I Y ++
Sbjct: 2703 STLHG-GTNSSAWVEVTTRPSRPAGVQPPVVTV-LEPDAVQVTWKPPLIQNGDILSYEIH 2760
Query: 986 YRNTSGTFMQNFTLHEVTNDFDNMTVSTIIDKLTIFSYYTFWLTASTSVGNG--NKSSDI 1043
+ + TL VT + +S + L F+ Y+ + A S GNG ++
Sbjct: 2761 MPD------PHITLTNVT----SAVLSQKVTHLIPFTNYSVTIVA-CSGGNGYLGGCTES 2809
Query: 1044 IEVY--TDQDIPEGFVGNLTYESISSTAINVSWVPPAQPNGLVFYYVSLILQ-QTPRHVR 1100
+ Y T +P+ VG L+ +S + + +SW PP++PNG Y L + Q P
Sbjct: 2810 LPTYVTTHPTVPQN-VGPLSVIPLSESYVVISWQPPSKPNGPNLRYELLRRKIQQPLASN 2868
Query: 1101 PP--------LVTYERSIYFD-NLEKYTDYILKITPSTEKGFSDTYTAQLYIKTEEDVPE 1151
PP + + + +Y D L ++T Y + GF T + ++ + T +PE
Sbjct: 2869 PPEDLNRWHNIYSGTQWLYEDKGLSRFTTYEYMLFVHNSVGF--TPSREVTVTTLAGLPE 2926
Query: 1152 TSPIINTFKNLSSTSVLLSWDPPVKPN--GAIISYDL--TLQGPNENYSFITSDNYIILE 1207
+ T L+ T++ + W P + G + Y L + N++ + N ++
Sbjct: 2927 RGANL-TASVLNHTAIDVRWAKPTVQDLQGEVEYYTLFWSSATSNDSLKILPDVNSHVIG 2985
Query: 1208 ELSPFTLYSFFAAARTRKGLGPSSILFFYTDESVP--LAPPQNLTLINCTSDFVWLKWSP 1265
L P T Y F + S+ L T + P + PP+ + +IN T+ V + W+
Sbjct: 2986 HLKPNTEYWIFISVFNGVHSINSAGLHATTCDGEPQGMLPPE-VVIINSTA--VRVIWTS 3042
Query: 1266 SPLPGGIVKVYSFKIHEHETDTIYYKNISGFKTEAKLVGLEPVSTYSIRVSAFTKVGNGN 1325
P G+V YS ++ YK L L P + Y I+V T
Sbjct: 3043 PSNPNGVVTEYSIYVNNK-----LYKTGMNVPGSFILRDLSPFTIYDIQVEVCTIYACVK 3097
Query: 1326 QFSNVVKFTTQESVPDVVQNMQCMATSWQSVLVKWDPPKKANGIITQY 1373
SN + TT E P + + +S+ + W P+K NGII Y
Sbjct: 3098 --SNGTQITTVEDTPSDIPTPTIRGITSRSLQIDWVSPRKPNGIILGY 3143
Score = 183 bits (465), Expect = 1e-45
Identities = 294/1264 (23%), Positives = 483/1264 (38%), Gaps = 149/1264 (11%)
Query: 121 LNPGTTYEIKVAAENSAGIGVFSDPFLFQTAESAPGKVVNLT-VEAYNASAVKLIWYLPR 179
L P T Y +V A + G V+SD +T +AP V + V + N ++++ W P
Sbjct: 1921 LQPFTEYLYRVIASHEGG-SVYSDWSRGRTTGAAPQSVPTPSRVRSLNGYSIEVTWDEP- 1978
Query: 180 QPNGKITSFKISVKHARSGIVVKDVSIRVE--------DILTGKLP-------------- 217
G I + + S + S E ILTG LP
Sbjct: 1979 VVRGVIEKYILKAYSEDSTRPPRMPSASAEFVNTSNLTGILTGLLPFKNYAVTLTACTLA 2038
Query: 218 ECNENSESFLWSTASPSPTLGRVTPPSRTTHSSSTLTQNEISSVWKEPI----------- 266
C E+S + ST +P V PP + SS L W P
Sbjct: 2039 GCTESSHALNISTPQEAPQ--EVQPPVAKSLPSSLLLS------WNPPKKANGIITQYCL 2090
Query: 267 -------------SFVVTHLRPYTTYLFEVSAATTEAGYIDSTIVRTPESVPEGPPQNCV 313
++ VT L +T + F +SA T S ++ +P + V
Sbjct: 2091 YMDGRLIYSGSEENYTVTDLAVFTPHQFLLSACTHVGCTNSSWVLLYTAQLPPEHVDSPV 2150
Query: 314 TGNITGKSFSILWDPPTIVTGKFSYRVELYGPSGR-------ILDNSTKDLK-FAFTNLT 365
+ ++ I W P ++G R LY + ++ NST+ + +
Sbjct: 2151 LTVLDSRTIHIQWKQPRKISGILE-RYVLYMSNHTHDFTIWSVIYNSTELFQDHMLQYVL 2209
Query: 366 PFTMYDVYIAAETSAGTGPKSNISVFTPPDVPGAVFDLQLAEVESTQVRITWKKPRQPNG 425
P Y + + A T G T D+P V + ++W +P PNG
Sbjct: 2210 PGNKYLIKLGACTGGGCTVSEASEALTDEDIPEGVPAPKAHSYSPDSFNVSWTEPEYPNG 2269
Query: 426 IINQYRVKVLVPETGIILENTLLTGNNEYINDPMAPEIVNI---------VEPMV--GLY 474
+I Y + + GI++ N+ Y P + + + P+V
Sbjct: 2270 VITSYGLYL----DGILIHNSSELSYRAYGFAPWSLHSFRVQACTAKGCALGPLVENRTL 2325
Query: 475 EGSAEMSSDLHSLATFIYNSHPDKNFPARNRAEDQTSPVVTTRNQYITDIA--------- 525
E E + ++ +H P R T V+ T Y+ +
Sbjct: 2326 EAPPEGTVNVFVKTQGSRKAHVRWEAPFRPNGL-LTHSVLFTGIFYVDPVGNNYTLLNVT 2384
Query: 526 -------AEQLSYVIRRLVPFTEHMISVSAFTIMGEGPPTVLSVRTRQQVPSSIKIINYK 578
L +I LVPFT + + V+ G +++ P +
Sbjct: 2385 KVMYSGEETNLWVLIDGLVPFTNYTVQVNISNSQGSLITDPITIAMPPGAPDGVLPPRLS 2444
Query: 579 NISSSSILLYWDPPEYPNGK-ITHYTIYAMELDTNRA----FQITTIDNSFLITGLKKYT 633
+ + +S+ + W P N Y + D+ F + S+ ++ L+ YT
Sbjct: 2445 SATPTSLQVVWSTPARNNAPGSPRYQLQMRSGDSTHGFLELFSNPSASLSYEVSDLQPYT 2504
Query: 634 KYKMRVAASTHVGESSLSEENDIFVRTSEDEPESSPQDVEVIDVTADEIRLKWSPPEKPN 693
+Y R+ AS G + S I T+ED+P + ++DV + + + W P K N
Sbjct: 2505 EYMFRLVASNGFGSAHSSW---IPFMTAEDKPGPVVPPI-LLDVKSRMMLVTWQHPRKSN 2560
Query: 694 GIIIAYEVLYKNIDTLYMKNT-STTDIILRNLRPHTLYNISVRSYTRFGHGNQVSSLLSV 752
G+I Y + LY++ + T+ + +L P+T Y V + T G S
Sbjct: 2561 GVITHYNIYLHG--RLYLRTPGNVTNCTVMHLHPYTAYKFQVEACTSKGCSLSPES---- 2614
Query: 753 RTSETVPDSAPENITYKNISSG---EIELSFLPPSSPNGIIQKYTIYLKRSNGNEERTIN 809
+T T+P APE I + S + +S+ PP+ PNG+++ +TI + E T+
Sbjct: 2615 QTVWTLP-GAPEGIPSPELFSDTPTSVIISWQPPTHPNGLVENFTIERRVKGKEEVTTLV 2673
Query: 810 TTSLTQNIKVLKK------YTQYIIEVSASTLKGEGVRSAPISILTEEDAPDSPPQDFSV 863
T + +++ + K +T+Y V STL G SA + + T P + Q V
Sbjct: 2674 TLPRSHSMRFIDKTSALSPWTKYEYRVLMSTLHGGTNSSAWVEVTTRPSRP-AGVQPPVV 2732
Query: 864 KQLSGVTVKLSWQPPLEPNGIILYYTVYVWN-RSSLKTINVTETSLELSDLDYNVEYSAY 922
L V+++W+PPL NG IL Y +++ + +L + S +++ L YS
Sbjct: 2733 TVLEPDAVQVTWKPPLIQNGDILSYEIHMPDPHITLTNVTSAVLSQKVTHLIPFTNYSVT 2792
Query: 923 VTASTRFGDGKTRSNIISFQTPEGAPSDPPKDV---YYANLSSSSIILFWTPPSKPNGII 979
+ A + G+G S T P++V LS S +++ W PPSKPNG
Sbjct: 2793 IVACSG-GNGYLGGCTESLPTYVTTHPTVPQNVGPLSVIPLSESYVVISWQPPSKPNGPN 2851
Query: 980 QYYSVYYRNTSGTFMQNFTLHEVTNDFDNMTVST---IIDK-LTIFSYYTFWLTASTSVG 1035
Y + R N E N + N+ T DK L+ F+ Y + L SV
Sbjct: 2852 LRYELLRRKIQQPLASN--PPEDLNRWHNIYSGTQWLYEDKGLSRFTTYEYMLFVHNSV- 2908
Query: 1036 NGNKSSDIIEVYTDQDIPEGFVGNLTYESISSTAINVSWVPPAQPN--GLVFYYVSLILQ 1093
G S + V T +PE NLT ++ TAI+V W P + G V YY +L
Sbjct: 2909 -GFTPSREVTVTTLAGLPER-GANLTASVLNHTAIDVRWAKPTVQDLQGEVEYY-TLFWS 2965
Query: 1094 QTPRHVRPPLVTYERSIYFDNLEKYTDYILKITPSTEKGFSDTYTAQLYIKTEEDVPETS 1153
+ ++ S +L+ T+Y + I S G +A L+ T + P+
Sbjct: 2966 SATSNDSLKILPDVNSHVIGHLKPNTEYWIFI--SVFNGVHSINSAGLHATTCDGEPQ-G 3022
Query: 1154 PIINTFKNLSSTSVLLSWDPPVKPNGAIISYDLTLQGPNENY-SFITSDNYIILEELSPF 1212
+ ++ST+V + W P PNG + Y + + N+ Y + + IL +LSPF
Sbjct: 3023 MLPPEVVIINSTAVRVIWTSPSNPNGVVTEYSIYVN--NKLYKTGMNVPGSFILRDLSPF 3080
Query: 1213 TLYSFFAAARTRKGLGPSSILFFYTDESVPLAPPQNLTLINCTSDFVWLKWSPSPLPGGI 1272
T+Y T S+ T E P P T+ TS + + W P GI
Sbjct: 3081 TIYDIQVEVCTIYACVKSNGTQITTVEDTPSDIP-TPTIRGITSRSLQIDWVSPRKPNGI 3139
Query: 1273 VKVY 1276
+ Y
Sbjct: 3140 ILGY 3143
Score = 165 bits (418), Expect = 4e-40
Identities = 254/1197 (21%), Positives = 464/1197 (38%), Gaps = 182/1197 (15%)
Query: 11 FIGTSETQVDVSNVVPGTRYDITISSISTTYTSPVTRIVTTNVTKPGPP-VFLAGERVGS 69
F+ TS ++ ++P Y +T+++ + + + + + + P V +
Sbjct: 2009 FVNTSNLTGILTGLLPFKNYAVTLTACTLAGCTESSHALNISTPQEAPQEVQPPVAKSLP 2068
Query: 70 AGILLSWNTPPNPNGRIISYIVKYKEVCPWMQTVYTQVRSKPDSLEVLLTNLNPGTTYEI 129
+ +LLSWN P NG I Y C +M S+ + +T+L T ++
Sbjct: 2069 SSLLLSWNPPKKANGIITQY-------CLYMDGRLIYSGSEEN---YTVTDLAVFTPHQF 2118
Query: 130 KVAAENSAGIGVFSDPFLFQTAESAPGKVVNLTVEAYNASAVKLIWYLPRQPNGKITSFK 189
++A G S L TA+ P V + + ++ + + W PR+ +G + +
Sbjct: 2119 LLSACTHVGC-TNSSWVLLYTAQLPPEHVDSPVLTVLDSRTIHIQWKQPRKISGILERYV 2177
Query: 190 ISVKHARSGIVVKDVSIR---------VEDILTG-----KLPEC-------NENSESFL- 227
+ + + + V ++ +L G KL C +E SE+
Sbjct: 2178 LYMSNHTHDFTIWSVIYNSTELFQDHMLQYVLPGNKYLIKLGACTGGGCTVSEASEALTD 2237
Query: 228 --WSTASPSPTLGRVTPPSRTTHSSSTLTQNEISSVWKEPISFVVTH-----------LR 274
P+P +P S + N + + + + ++ H
Sbjct: 2238 EDIPEGVPAPKAHSYSPDSFNVSWTEPEYPNGVITSYGLYLDGILIHNSSELSYRAYGFA 2297
Query: 275 PYTTYLFEVSAATTEAGYIDSTIV-RTPESVPEGPPQNCVTGNITGKSFSILWDPPTIVT 333
P++ + F V A T + + + RT E+ PEG N + + W+ P
Sbjct: 2298 PWSLHSFRVQACTAKGCALGPLVENRTLEAPPEG-TVNVFVKTQGSRKAHVRWEAPFRPN 2356
Query: 334 GKFSYRVELYG-----PSGR--ILDNSTK--------DLKFAFTNLTPFTMYDVYIAAET 378
G ++ V G P G L N TK +L L PFT Y V +
Sbjct: 2357 GLLTHSVLFTGIFYVDPVGNNYTLLNVTKVMYSGEETNLWVLIDGLVPFTNYTVQVNISN 2416
Query: 379 SAGTGPKSNISVFTPPDVPGAVFDLQLAEVESTQVRITWKKPRQPN-------------- 424
S G+ I++ PP P V +L+ T +++ W P + N
Sbjct: 2417 SQGSLITDPITIAMPPGAPDGVLPPRLSSATPTSLQVVWSTPARNNAPGSPRYQLQMRSG 2476
Query: 425 ----GIIN---------QYRVKVLVPET----GIILENTLLTGNNEYINDPMAPEIVNIV 467
G + Y V L P T ++ N + ++ +I A + V
Sbjct: 2477 DSTHGFLELFSNPSASLSYEVSDLQPYTEYMFRLVASNGFGSAHSSWIPFMTAEDKPGPV 2536
Query: 468 EPMVGLYEGSAEMSSDLHSLATFIYNSHPDKNFPARNRAEDQTSPVVTTRNQYI-----T 522
P + L D+ S + HP K ++ V+T N Y+
Sbjct: 2537 VPPILL---------DVKSRMMLVTWQHPRK-----------SNGVITHYNIYLHGRLYL 2576
Query: 523 DIAAEQLSYVIRRLVPFTEHMISVSAFTIMG-EGPPTVLSVRTRQQVPSSIKIINYKNIS 581
+ + L P+T + V A T G P +V T P I + +
Sbjct: 2577 RTPGNVTNCTVMHLHPYTAYKFQVEACTSKGCSLSPESQTVWTLPGAPEGIPSPELFSDT 2636
Query: 582 SSSILLYWDPPEYPNGKITHYTIYAMELDTNRAFQITTIDNSFLI------TGLKKYTKY 635
+S+++ W PP +PNG + ++TI + T+ S + + L +TKY
Sbjct: 2637 PTSVIISWQPPTHPNGLVENFTIERRVKGKEEVTTLVTLPRSHSMRFIDKTSALSPWTKY 2696
Query: 636 KMRVAASTHVGESSLSEENDIFVRTSEDEPESSPQDVEVIDVTADEIRLKWSPPEKPNGI 695
+ RV ST G ++ S ++ R S + Q V + D +++ W PP NG
Sbjct: 2697 EYRVLMSTLHGGTNSSAWVEVTTRPSR---PAGVQPPVVTVLEPDAVQVTWKPPLIQNGD 2753
Query: 696 IIAYEVLYKNIDTLYMKNTSTTDIIL----RNLRPHTLYNISVRSYTRFGHGNQVSSLLS 751
I++YE+ ++ ++ T+ T +L +L P T Y++++ + + G+G S
Sbjct: 2754 ILSYEI---HMPDPHITLTNVTSAVLSQKVTHLIPFTNYSVTIVACSG-GNGYLGGCTES 2809
Query: 752 VRTSETVPDSAPENI---TYKNISSGEIELSFLPPSSPNGIIQKYTIYLKR------SNG 802
+ T T + P+N+ + +S + +S+ PPS PNG +Y + ++ SN
Sbjct: 2810 LPTYVTTHPTVPQNVGPLSVIPLSESYVVISWQPPSKPNGPNLRYELLRRKIQQPLASNP 2869
Query: 803 NEE--RTINTTSLTQNI---KVLKKYTQYIIEVSASTLKGEGVRSAPISILTEEDAPDSP 857
E+ R N S TQ + K L ++T Y + G S +++ T P+
Sbjct: 2870 PEDLNRWHNIYSGTQWLYEDKGLSRFTTYEYMLFVHNSVG-FTPSREVTVTTLAGLPER- 2927
Query: 858 PQDFSVKQLSGVTVKLSWQPPL--EPNGIILYYTVYVWNRSSLKTINVTE--TSLELSDL 913
+ + L+ + + W P + G + YYT++ + +S ++ + S + L
Sbjct: 2928 GANLTASVLNHTAIDVRWAKPTVQDLQGEVEYYTLFWSSATSNDSLKILPDVNSHVIGHL 2987
Query: 914 DYNVEYSAYVTASTRFGDGKTRSNIISFQTPEGAPSD--PPKDVYYANLSSSSIILFWTP 971
N EY +++ G S + T +G P PP+ V ++S+++ + WT
Sbjct: 2988 KPNTEYWIFISVFN--GVHSINSAGLHATTCDGEPQGMLPPEVVI---INSTAVRVIWTS 3042
Query: 972 PSKPNGIIQYYSVYYRNTSGTFMQNFTLHEVTNDFDNMTVSTI-IDKLTIFSYYTFWLTA 1030
PS PNG++ YS+Y N N + D T+ I ++ TI++
Sbjct: 3043 PSNPNGVVTEYSIYVNNKLYKTGMNVPGSFILRDLSPFTIYDIQVEVCTIYACVK----- 3097
Query: 1031 STSVGNGNKSSDIIEVYTDQDIPEGFVGNLTYESISSTAINVSWVPPAQPNGLVFYY 1087
NG + + + + T DIP T I+S ++ + WV P +PNG++ Y
Sbjct: 3098 ----SNGTQITTVED--TPSDIP-----TPTIRGITSRSLQIDWVSPRKPNGIILGY 3143
Score = 97.4 bits (241), Expect = 1e-19
Identities = 122/467 (26%), Positives = 200/467 (42%), Gaps = 81/467 (17%)
Query: 581 SSSSILLYWDPPEYPNGKITHYTIYAMELDTNRAFQITTIDNS-------FLITGLKKYT 633
SSS+I L W PP+ PN H+ Y++ D F+I T ++ FL T L YT
Sbjct: 1066 SSSAINLSWSPPDSPNA---HWLTYSLLRD---GFEIYTTEDQYPYSIQYFLDTDLLPYT 1119
Query: 634 KYKMRVAASTHVGESSLSEENDIFVRTSEDEPESSPQDVEVIDVTADEIRLKWSPPEKPN 693
KY + +T+V S+ S + +T PE + +I + +D + L W+ +
Sbjct: 1120 KYSYYIE-TTNVHGSTRSVA--VTYKTKPGVPEGNLTLSYIIPIGSDSVTLTWTTLSNQS 1176
Query: 694 GIIIAYEVLYKNI---DTLYMKNTSTTDIILRNLRPHTLYNISVRSYTRFGHGNQVSSLL 750
G I Y + + T + NL P Y+ SV++ T G L
Sbjct: 1177 GPIEKYILSCAPLAGGQPCVSYEGHETSATIWNLVPFAKYDFSVQACTSGG------CLH 1230
Query: 751 SVRTSETVPDSAPENIT---YKNISSGEIELSFLPPSSPNGIIQKYTIYLKRSNGNEERT 807
S+ + T + P+ ++ + ISS E+ + + PP+ NGII +Y +Y++R +E T
Sbjct: 1231 SLPITVTTAQAPPQRLSPPKMQKISSTELHVEWSPPAELNGIIIRYELYMRRLRSTKETT 1290
Query: 808 INTTSLTQN--------------------------IKVLKKYTQYIIEVSASTLKGEGVR 841
+ + Q+ I L+ YT+Y V A + G V
Sbjct: 1291 SEESRVFQSSGWLSPHSFVESANENALKPPQTMTTITGLEPYTKYEFRVLAVNMAG-SVS 1349
Query: 842 SAPISILTEEDAP--DSPPQDFSVKQLSGVTVKLSWQPPLE--PNGIILYYTVYVWN-RS 896
SA +S T E AP PP SV LS ++ +SW+ P + G ++ Y + + + +S
Sbjct: 1350 SAWVSERTGESAPVFMIPP---SVFPLSSYSLNISWEKPADNVTRGKVVGYDINMLSEQS 1406
Query: 897 SLKTINVTETSL----ELSDLDYNVE-------YSAYVTASTRFGDGKTRSNIISFQTPE 945
++I + + L + +L Y VE Y +T G + S + QT
Sbjct: 1407 PQQSIPMAFSQLLHTAKSQELSYTVEGLKPYRIYEFTITLCNSVGCVTSASG--AGQTLA 1464
Query: 946 GAPSD--PPKDVYYANLSSSSIILFWTPPSKPNGIIQYYSVYYRNTS 990
AP+ PP ++S++I L W PP + NG Y + R +S
Sbjct: 1465 AAPAQLRPP---LVKGINSTTIHLKWFPPEELNGPSPIYQLERRESS 1508
Score = 93.6 bits (231), Expect = 2e-18
Identities = 155/689 (22%), Positives = 265/689 (38%), Gaps = 106/689 (15%)
Query: 1107 ERSIYFDNLEKYTDYILKITPSTEKGFSDTYTAQLYIKTEEDVPETSPIINTFKNLSSTS 1166
E+S+Y L+ +T+Y+ ++ S E G Y+ +T P++ P + ++L+ S
Sbjct: 1913 EQSVYEGGLQPFTEYLYRVIASHEGG--SVYSDWSRGRTTGAAPQSVPTPSRVRSLNGYS 1970
Query: 1167 VLLSWDPPVKPNGAIISYDLTLQG---------PNENYSFITSDNYI-ILEELSPFTLYS 1216
+ ++WD PV G I Y L P+ + F+ + N IL L PF Y+
Sbjct: 1971 IEVTWDEPV-VRGVIEKYILKAYSEDSTRPPRMPSASAEFVNTSNLTGILTGLLPFKNYA 2029
Query: 1217 FFAAARTRKGLGPSSILFFYTDESVPLAPPQNL--TLINCTSDFVWLKWSPSPLPGGIVK 1274
A T G SS + S P PQ + + + L W+P GI+
Sbjct: 2030 VTLTACTLAGCTESS---HALNISTPQEAPQEVQPPVAKSLPSSLLLSWNPPKKANGIIT 2086
Query: 1275 VYSFKIHEHETDTIYYKNISGFKTEAKLVGLEPVSTYSIRVSAFTKVGNGNQFSNVVKFT 1334
Y + + IY SG + + L + + +SA T VG N S+ V
Sbjct: 2087 QYCLYM---DGRLIY----SGSEENYTVTDLAVFTPHQFLLSACTHVGCTN--SSWVLLY 2137
Query: 1335 TQESVPDVVQNMQCMATSWQSVLVKWDPPKKANGIITQYMV------------TVERNST 1382
T + P+ V + +++ ++W P+K +GI+ +Y++ +V NST
Sbjct: 2138 TAQLPPEHVDSPVLTVLDSRTIHIQWKQPRKISGILERYVLYMSNHTHDFTIWSVIYNST 2197
Query: 1383 KVSPQDHMYTFIKLLANTSYVFKVRASTSAG----EGDESTCHVSTLPETVPSVPTNIAF 1438
++ QDHM ++ L Y+ K+ A T G E E+ +PE VP+ +
Sbjct: 2198 ELF-QDHMLQYV--LPGNKYLIKLGACTGGGCTVSEASEALTD-EDIPEGVPAPKAHSYS 2253
Query: 1439 SDVQSTSATLTWIRPDTILGYFQNYKITTQLRAQKCKEWESEECVEYQKIQYLYEAHLTE 1498
D S ++W P+ G +Y + Y ++ +
Sbjct: 2254 PD----SFNVSWTEPEYPNGVITSYGL-------------------YLDGILIHNSSELS 2290
Query: 1499 ETVYGLKKFRWYRFQVAASTNAGYGNASNWISTKTLPGPPDGPPENVHVVATSPFSISIS 1558
YG + + F+V A T G + +TL PP+G NV V +
Sbjct: 2291 YRAYGFAPWSLHSFRVQACTAKGCA-LGPLVENRTLEAPPEG-TVNVFVKTQGSRKAHVR 2348
Query: 1559 WSEP----AVITGPTCY--LIDVKSVDNDEFNISFIK----SNEENKTIEIKDLEIFTRY 1608
W P ++T + + V V N+ ++ K E N + I L FT Y
Sbjct: 2349 WEAPFRPNGLLTHSVLFTGIFYVDPVGNNYTLLNVTKVMYSGEETNLWVLIDGLVPFTNY 2408
Query: 1609 SVVITAFTGNISAAYVEGKSSAEMIVTTLESAPKDPPNNMTFQKIPDEVTKFQLTFLPPS 1668
+V + NIS + +G + I T+ P P + + T Q+ + P+
Sbjct: 2409 TVQV-----NISNS--QGSLITDPI--TIAMPPGAPDGVLPPRLSSATPTSLQVVWSTPA 2459
Query: 1669 QPNGNIQVYQALVYREDD-----------PTAVQIHNLSIIQKTNTFVIAML--EGLKGG 1715
+ N L R D P+A + +S +Q ++ ++ G
Sbjct: 2460 RNNAPGSPRYQLQMRSGDSTHGFLELFSNPSASLSYEVSDLQPYTEYMFRLVASNGFGSA 2519
Query: 1716 HTYNISVYAVNSAGAGPKVPMRITMDIKA 1744
H+ I GP VP I +D+K+
Sbjct: 2520 HSSWIPFMTAEDK-PGPVVP-PILLDVKS 2546
Score = 88.6 bits (218), Expect = 6e-17
Identities = 139/628 (22%), Positives = 248/628 (39%), Gaps = 85/628 (13%)
Query: 1147 EDVPETSPIINTFKNLSSTSVLLSWDPPVKPNGAIISYDLTLQGPNENYSFITSDNYIIL 1206
+DV T + ++SS +V ++ D + + A+ +G + + + +
Sbjct: 1864 KDVKFTRGAVVNLASVSSGAVRVNLDGCLSTDSAV-----NCRGNDSILVYQGKEQSVYE 1918
Query: 1207 EELSPFTLYSFFAAARTRKGLGPSSILFFYTDESVPLAPPQNLTLINCTSDFVWLKWSPS 1266
L PFT Y + A G S T + P + P + + + + W
Sbjct: 1919 GGLQPFTEYLYRVIASHEGGSVYSDWSRGRTTGAAPQSVPTPSRVRSLNGYSIEVTWD-E 1977
Query: 1267 PLPGGIVKVYSFKIHEHET-----------DTIYYKNISGFKTEAKLVGLEPVSTYSIRV 1315
P+ G+++ Y K + ++ + + N++G L GL P Y++ +
Sbjct: 1978 PVVRGVIEKYILKAYSEDSTRPPRMPSASAEFVNTSNLTGI-----LTGLLPFKNYAVTL 2032
Query: 1316 SAFTKVGNGNQFSNVVKFTTQESVPDVVQNMQCMATSWQSVLVKWDPPKKANGIITQYMV 1375
+A T G + S+ + +T + P VQ + S+L+ W+PPKKANGIITQY +
Sbjct: 2033 TACTLAGC-TESSHALNISTPQEAPQEVQPPVAKSLP-SSLLLSWNPPKKANGIITQYCL 2090
Query: 1376 TVERNSTKVSPQDHMYTFIKLLANTSYVFKVRASTSAGEGDESTCHVSTL---PETVPSV 1432
++ S + YT L T + F + A T G + S + T PE V S
Sbjct: 2091 YMD-GRLIYSGSEENYTVTDLAVFTPHQFLLSACTHVGCTNSSWVLLYTAQLPPEHVDSP 2149
Query: 1433 PTNIAFSDVQSTSATLTWIRPDTILGYFQNYKITTQLRAQKCKEWESEECVEYQKIQYLY 1492
+ + S + + W +P I G + Y + W V Y + L+
Sbjct: 2150 VLTV----LDSRTIHIQWKQPRKISGILERYVLYMSNHTHDFTIWS----VIYNSTE-LF 2200
Query: 1493 EAHLTEETVYGLKKFRWYRFQVAASTNAG--YGNASNWISTKTLPGPPDGPPENVHVVAT 1550
+ H+ + + G K Y ++ A T G AS ++ + +P P + +
Sbjct: 2201 QDHMLQYVLPGNK----YLIKLGACTGGGCTVSEASEALTDEDIPEGVPAPKAHSY---- 2252
Query: 1551 SPFSISISWSEP----AVITGPTCYLIDVKSVDNDEFNISFIKSNEENKTIEIKDLEIFT 1606
SP S ++SW+EP VIT YL + + N + ++
Sbjct: 2253 SPDSFNVSWTEPEYPNGVITSYGLYLDGI------------LIHNSSELSYRAYGFAPWS 2300
Query: 1607 RYSVVITAFT--GNISAAYVEGKSSAEMIVTTLESAPKDPPNNMTFQKIPDEVTKFQLTF 1664
+S + A T G VE + TLE+ P+ N F K K + +
Sbjct: 2301 LHSFRVQACTAKGCALGPLVENR--------TLEAPPEGTVN--VFVKTQGS-RKAHVRW 2349
Query: 1665 LPPSQPNGNIQ---VYQALVYREDDPTAVQIHNLSII----QKTNTFVIAMLEGLKGGHT 1717
P +PNG + ++ + Y + + N++ + ++TN +V +++GL
Sbjct: 2350 EAPFRPNGLLTHSVLFTGIFYVDPVGNNYTLLNVTKVMYSGEETNLWV--LIDGLVPFTN 2407
Query: 1718 YNISVYAVNSAGAGPKVPMRITMDIKAP 1745
Y + V NS G+ P+ I M AP
Sbjct: 2408 YTVQVNISNSQGSLITDPITIAMPPGAP 2435
Score = 87.0 bits (214), Expect = 2e-16
Identities = 150/687 (21%), Positives = 253/687 (36%), Gaps = 112/687 (16%)
Query: 7 FLLLFIGTSET-QVDVSNVVPGTRYDITI---SSISTTYTSPVTRIVTTNVTKPGPPVFL 62
FL LF S + +VS++ P T Y + + + ++S + + + KPGP V
Sbjct: 2482 FLELFSNPSASLSYEVSDLQPYTEYMFRLVASNGFGSAHSSWIPFMTAED--KPGPVVPP 2539
Query: 63 AGERVGSAGILLSWNTPPNPNGRIISYIVKYKEVCPWMQTVYTQVRSKPDSLEVLLTNLN 122
V S +L++W P NG I Y + +R+ + + +L+
Sbjct: 2540 ILLDVKSRMMLVTWQHPRKSNGVITHYNIYLHG--------RLYLRTPGNVTNCTVMHLH 2591
Query: 123 PGTTYEIKVAAENSAGIGVFSDPFLFQTAESAPGKVVNLTVEAYNASAVKLIWYLPRQPN 182
P T Y+ +V A S G + + T AP + + + + ++V + W P PN
Sbjct: 2592 PYTAYKFQVEACTSKGCSLSPESQTVWTLPGAPEGIPSPELFSDTPTSVIISWQPPTHPN 2651
Query: 183 GKITSF----KISVKHARSGIVV--KDVSIRVEDILTGKLP-------------ECNENS 223
G + +F ++ K + +V + S+R D + P NS
Sbjct: 2652 GLVENFTIERRVKGKEEVTTLVTLPRSHSMRFIDKTSALSPWTKYEYRVLMSTLHGGTNS 2711
Query: 224 ESFLWSTASPSPTLGRVTPPSRTTHSSSTLTQNEISSVWKEP------------------ 265
+++ T PS G V PP T L + + WK P
Sbjct: 2712 SAWVEVTTRPSRPAG-VQPPVVT-----VLEPDAVQVTWKPPLIQNGDILSYEIHMPDPH 2765
Query: 266 ----------ISFVVTHLRPYTTYLFEVSAATTEAGYIDSTIVRTPESVPEGP--PQNCV 313
+S VTHL P+T Y + A + GY+ P V P PQN
Sbjct: 2766 ITLTNVTSAVLSQKVTHLIPFTNYSVTIVACSGGNGYLGGCTESLPTYVTTHPTVPQNVG 2825
Query: 314 TGNITGKSFS---ILWDPPTIVTG-KFSYRVELYGPSGRILDNSTKDLK----------- 358
++ S S I W PP+ G Y + + N +DL
Sbjct: 2826 PLSVIPLSESYVVISWQPPSKPNGPNLRYELLRRKIQQPLASNPPEDLNRWHNIYSGTQW 2885
Query: 359 -FAFTNLTPFTMYDVYIAAETSAGTGPKSNISVFTPPDVPGAVFDLQLAEVESTQVRITW 417
+ L+ FT Y+ + S G P ++V T +P +L + + T + + W
Sbjct: 2886 LYEDKGLSRFTTYEYMLFVHNSVGFTPSREVTVTTLAGLPERGANLTASVLNHTAIDVRW 2945
Query: 418 KKP--RQPNGIINQYRVKVLVPETGIILENTLLTGNNEYINDPMAPEIVNIVEPMVGLYE 475
KP + G + Y + + L+ +L N ++ + P + + ++
Sbjct: 2946 AKPTVQDLQGEVEYYTLFWSSATSNDSLK--ILPDVNSHVIGHLKPNTEYWI--FISVFN 3001
Query: 476 GSAEM-SSDLHSLATFIYNSHPDKNFPARNRAEDQ-------TSP-----VVTTRNQYIT 522
G + S+ LH+ + P P + TSP VVT + Y+
Sbjct: 3002 GVHSINSAGLHATTC---DGEPQGMLPPEVVIINSTAVRVIWTSPSNPNGVVTEYSIYVN 3058
Query: 523 DIAAE-----QLSYVIRRLVPFTEHMISVSAFTIMGEGPPTVLSVRTRQQVPSSIKIINY 577
+ + S+++R L PFT + I V TI + T + PS I
Sbjct: 3059 NKLYKTGMNVPGSFILRDLSPFTIYDIQVEVCTIYACVKSNGTQITTVEDTPSDIPTPTI 3118
Query: 578 KNISSSSILLYWDPPEYPNGKITHYTI 604
+ I+S S+ + W P PNG I Y +
Sbjct: 3119 RGITSRSLQIDWVSPRKPNGIILGYDL 3145
Score = 77.0 bits (188), Expect = 2e-13
Identities = 109/483 (22%), Positives = 185/483 (38%), Gaps = 67/483 (13%)
Query: 961 SSSSIILFWTPPSKPNGIIQYYSVYYRNTSGTFMQNFTLHEVTNDFDNMTVSTIIDKLTI 1020
SSS+I L W+PP PN YS+ F ++ + + + L
Sbjct: 1066 SSSAINLSWSPPDSPNAHWLTYSL--------LRDGFEIYTTEDQYPYSIQYFLDTDLLP 1117
Query: 1021 FSYYTFWLTASTSVGNGNKSSDIIEVYTDQDIPEGFVGNLTYE---SISSTAINVSWVPP 1077
++ Y++++ T+ +G+ S + T +PEG NLT I S ++ ++W
Sbjct: 1118 YTKYSYYI--ETTNVHGSTRSVAVTYKTKPGVPEG---NLTLSYIIPIGSDSVTLTWTTL 1172
Query: 1078 AQPNGLVFYYVSLILQQTPRHVRPPLVTYE---RSIYFDNLEKYTDYILKITPSTEKGFS 1134
+ +G + Y IL P P V+YE S NL + Y + T G
Sbjct: 1173 SNQSGPIEKY---ILSCAPLAGGQPCVSYEGHETSATIWNLVPFAKYDFSVQACTSGGC- 1228
Query: 1135 DTYTAQLYIKTEEDVPET-SPIINTFKNLSSTSVLLSWDPPVKPNGAIISYDLTLQ---- 1189
++ + + T + P+ SP + +SST + + W PP + NG II Y+L ++
Sbjct: 1229 -LHSLPITVTTAQAPPQRLSP--PKMQKISSTELHVEWSPPAELNGIIIRYELYMRRLRS 1285
Query: 1190 ---------------GPNENYSFITSDNYIILEE---------LSPFTLYSFFAAARTRK 1225
G +SF+ S N L+ L P+T Y F A
Sbjct: 1286 TKETTSEESRVFQSSGWLSPHSFVESANENALKPPQTMTTITGLEPYTKYEFRVLAVNMA 1345
Query: 1226 GLGPSSILFFYTDESVP--LAPPQNLTLINCTSDFVWLKWSPSPLPGGIVKVYSFKIHEH 1283
G S+ + T ES P + PP L + + + W K + + G +V + E
Sbjct: 1346 GSVSSAWVSERTGESAPVFMIPPSVFPLSSYSLNISWEKPADNVTRGKVVGYDINMLSEQ 1405
Query: 1284 ETDTIYYKNISGFKTEAK-------LVGLEPVSTYSIRVSAFTKVGNGNQFSNVVKFTTQ 1336
S AK + GL+P Y ++ VG S + T
Sbjct: 1406 SPQQSIPMAFSQLLHTAKSQELSYTVEGLKPYRIYEFTITLCNSVGCVTSASGAGQ--TL 1463
Query: 1337 ESVPDVVQNMQCMATSWQSVLVKWDPPKKANGIITQYMVTVERNSTKVSPQDHMYTFIKL 1396
+ P ++ + ++ +KW PP++ NG Y + R S+ + M I+
Sbjct: 1464 AAAPAQLRPPLVKGINSTTIHLKWFPPEELNGPSPIYQLE-RRESSLPALMTTMMKGIRF 1522
Query: 1397 LAN 1399
+ N
Sbjct: 1523 IGN 1525
Score = 71.2 bits (173), Expect = 1e-11
Identities = 98/414 (23%), Positives = 164/414 (39%), Gaps = 57/414 (13%)
Query: 513 VVTTRNQYITDIAAEQLSYVIRRLVPFTEHMISVSAFTIMGEGPPTVLSVRTRQQVPSSI 572
+ TT +QY I ++ L+P+T++ + + G ++ +T+ VP
Sbjct: 1096 IYTTEDQYPYSIQY----FLDTDLLPYTKYSYYIETTNVHGSTRSVAVTYKTKPGVPEGN 1151
Query: 573 KIINY-KNISSSSILLYWDPPEYPNGKITHYTIYAMELDTNR-AFQITTIDNSFLITGLK 630
++Y I S S+ L W +G I Y + L + + S I L
Sbjct: 1152 LTLSYIIPIGSDSVTLTWTTLSNQSGPIEKYILSCAPLAGGQPCVSYEGHETSATIWNLV 1211
Query: 631 KYTKYKMRVAASTHVGESSLSEENDIFVRTSEDEPES-SPQDVEVIDVTADEIRLKWSPP 689
+ KY V A T G I V T++ P+ SP ++ I T E+ ++WSPP
Sbjct: 1212 PFAKYDFSVQACTSGG---CLHSLPITVTTAQAPPQRLSPPKMQKISST--ELHVEWSPP 1266
Query: 690 EKPNGIIIAYEVLYKNIDTLYMKNTSTTDIILRN---LRPHTLYN--------------- 731
+ NGIII YE+ + + + + TS + ++ L PH+
Sbjct: 1267 AELNGIIIRYELYMRRLRST-KETTSEESRVFQSSGWLSPHSFVESANENALKPPQTMTT 1325
Query: 732 -ISVRSYTRFGHG----NQVSSLLSVRTSETVPDSAPENITYKNI---SSGEIELSFLPP 783
+ YT++ N S+ S SE +SAP + ++ SS + +S+ P
Sbjct: 1326 ITGLEPYTKYEFRVLAVNMAGSVSSAWVSERTGESAPVFMIPPSVFPLSSYSLNISWEKP 1385
Query: 784 SS--PNGIIQKYTIYLKRSNGNEE----------RTINTTSLTQNIKVLKKYTQYIIEVS 831
+ G + Y I + ++ T + L+ ++ LK Y Y ++
Sbjct: 1386 ADNVTRGKVVGYDINMLSEQSPQQSIPMAFSQLLHTAKSQELSYTVEGLKPYRIYEFTIT 1445
Query: 832 ASTLKGEGVRSAPISILTEEDAPDS--PPQDFSVKQLSGVTVKLSWQPPLEPNG 883
G V SA + T AP PP VK ++ T+ L W PP E NG
Sbjct: 1446 LCNSVG-CVTSASGAGQTLAAAPAQLRPP---LVKGINSTTIHLKWFPPEELNG 1495
Score = 68.9 bits (167), Expect = 5e-11
Identities = 105/455 (23%), Positives = 172/455 (37%), Gaps = 58/455 (12%)
Query: 772 SSGEIELSFLPPSSPNGIIQKYTIYLKRSNGNEERTINTTSLTQNIKV-------LKKYT 824
SS I LS+ PP SPN Y++ +G E I TT + L YT
Sbjct: 1066 SSSAINLSWSPPDSPNAHWLTYSLL---RDGFE---IYTTEDQYPYSIQYFLDTDLLPYT 1119
Query: 825 QYIIEVSASTLKGEGVRSAPISILTEEDAPDSPPQDFSVKQLSGVTVKLSWQPPLEPNGI 884
+Y + + + G RS ++ T+ P+ + + +V L+W +G
Sbjct: 1120 KYSYYIETTNVHGS-TRSVAVTYKTKPGVPEGNLTLSYIIPIGSDSVTLTWTTLSNQSGP 1178
Query: 885 ILYYTVY---VWNRSSLKTINVTETSLELSDLDYNVEYSAYVTASTRFGDGKTRSNIISF 941
I Y + + + ETS + +L +Y V A T G S I+
Sbjct: 1179 IEKYILSCAPLAGGQPCVSYEGHETSATIWNLVPFAKYDFSVQACT--SGGCLHSLPITV 1236
Query: 942 QTPEGAPS--DPPKDVYYANLSSSSIILFWTPPSKPNGIIQYYSVYYRNTSGT------- 992
T + P PPK +SS+ + + W+PP++ NGII Y +Y R T
Sbjct: 1237 TTAQAPPQRLSPPK---MQKISSTELHVEWSPPAELNGIIIRYELYMRRLRSTKETTSEE 1293
Query: 993 ----------FMQNFTLHEVTNDFDNMTVSTIIDKLTIFSYYTFWLTASTSVGNGNKSSD 1042
+F N T I L ++ Y F + A G+ SS
Sbjct: 1294 SRVFQSSGWLSPHSFVESANENALKPPQTMTTITGLEPYTKYEFRVLAVNMA--GSVSSA 1351
Query: 1043 IIEVYTDQDIPEGFVGNLTYESISSTAINVSWVPPAQ---PNGLVFYYVSLILQQTPRHV 1099
+ T + P + + +SS ++N+SW PA +V Y ++++ +Q+P+
Sbjct: 1352 WVSERTGESAPVFMIPPSVF-PLSSYSLNISWEKPADNVTRGKVVGYDINMLSEQSPQQS 1410
Query: 1100 RP--------PLVTYERSIYFDNLEKYTDYILKITPSTEKGFSDTYTAQLYIKTEEDVPE 1151
P + E S + L+ Y Y IT G + +
Sbjct: 1411 IPMAFSQLLHTAKSQELSYTVEGLKPYRIYEFTITLCNSVGCVTSASGAGQTLAAAPAQL 1470
Query: 1152 TSPIINTFKNLSSTSVLLSWDPPVKPNGAIISYDL 1186
P++ K ++ST++ L W PP + NG Y L
Sbjct: 1471 RPPLV---KGINSTTIHLKWFPPEELNGPSPIYQL 1502
Score = 67.8 bits (164), Expect = 1e-10
Identities = 120/470 (25%), Positives = 192/470 (40%), Gaps = 80/470 (17%)
Query: 1255 TSDFVWLKWSPSPLPGGIVKVYS-----FKIHEHETDTIYYKNISGFKTEAKLVGLEPVS 1309
+S + L WSP P YS F+I+ T+ Y +I F L P +
Sbjct: 1066 SSSAINLSWSPPDSPNAHWLTYSLLRDGFEIYT--TEDQYPYSIQYFLD----TDLLPYT 1119
Query: 1310 TYSIRVSAFTKVGNGNQFSNVVKFTTQESVPDVVQNMQ-CMATSWQSVLVKWDPPKKANG 1368
YS + T V +G+ S V + T+ VP+ + + SV + W +G
Sbjct: 1120 KYSYYIET-TNV-HGSTRSVAVTYKTKPGVPEGNLTLSYIIPIGSDSVTLTWTTLSNQSG 1177
Query: 1369 IITQYMVT---VERNSTKVSPQDH--MYTFIKLLANTSYVFKVRASTSAGEGDESTCHVS 1423
I +Y+++ + VS + H T L+ Y F V+A TS G C +
Sbjct: 1178 PIEKYILSCAPLAGGQPCVSYEGHETSATIWNLVPFAKYDFSVQACTSGG------C-LH 1230
Query: 1424 TLPETVPSV---PTNIAFSDVQSTSAT---LTWIRPDTILGYFQNYKITTQLRAQKCKEW 1477
+LP TV + P ++ +Q S+T + W P + G Y++ + R + KE
Sbjct: 1231 SLPITVTTAQAPPQRLSPPKMQKISSTELHVEWSPPAELNGIIIRYELYMR-RLRSTKET 1289
Query: 1478 ESEECVEYQKIQYLYEAHLTEE-------------TVYGLKKFRWYRFQVAASTNAGYGN 1524
SEE +Q +L E T+ GL+ + Y F+V A AG
Sbjct: 1290 TSEESRVFQSSGWLSPHSFVESANENALKPPQTMTTITGLEPYTKYEFRVLAVNMAG-SV 1348
Query: 1525 ASNWISTKTLPGPPDG--PPENVHVVATSPFSISISWSEPA--VITGPTC-YLIDVKSVD 1579
+S W+S +T P PP V S +S++ISW +PA V G Y I++ S
Sbjct: 1349 SSAWVSERTGESAPVFMIPPS---VFPLSSYSLNISWEKPADNVTRGKVVGYDINMLSEQ 1405
Query: 1580 NDEFNISFI--------KSNEENKTIE-IKDLEIFTRYSVVITAFTGNISAAYVEGKSSA 1630
+ + +I KS E + T+E +K I+ +++ + G +++A G+
Sbjct: 1406 SPQQSIPMAFSQLLHTAKSQELSYTVEGLKPYRIY-EFTITLCNSVGCVTSASGAGQ--- 1461
Query: 1631 EMIVTTLESAPKD--PPNNMTFQKIPDEVTKFQLTFLPPSQPNGNIQVYQ 1678
TL +AP PP T L + PP + NG +YQ
Sbjct: 1462 -----TLAAAPAQLRPPLVKGINS-----TTIHLKWFPPEELNGPSPIYQ 1501
Score = 66.2 bits (160), Expect = 3e-10
Identities = 96/427 (22%), Positives = 165/427 (38%), Gaps = 67/427 (15%)
Query: 22 SNVVPGTRYDITISSISTTYTSPVTRIVTTNVTKPGPP----VFLAGERVGSAGILLSWN 77
++++P T+Y I + T + T TKPG P +GS + L+W
Sbjct: 1113 TDLLPYTKYSYYIET--TNVHGSTRSVAVTYKTKPGVPEGNLTLSYIIPIGSDSVTLTWT 1170
Query: 78 TPPNPNGRIISYIVKYKEVCPWMQTVYTQVRSKPDSLEVLLTNLNPGTTYEIKVAAENSA 137
T N +G I YI+ C + V + + NL P Y+ V A S
Sbjct: 1171 TLSNQSGPIEKYILS----CAPLAGGQPCVSYEGHETSATIWNLVPFAKYDFSVQACTSG 1226
Query: 138 GIGVFSDPFLFQTAESAPGKVVNLTVEAYNASAVKLIWYLPRQPNGKITSFKISVKHARS 197
G + S P TA++ P ++ ++ +++ + + W P + NG I +++ ++ RS
Sbjct: 1227 GC-LHSLPITVTTAQAPPQRLSPPKMQKISSTELHVEWSPPAELNGIIIRYELYMRRLRS 1285
Query: 198 GIVVKDVSIRVEDILTGKLPECNENSESFLWSTASPSPTLGRVTPPSRTTHSSSTLTQNE 257
K+ + +E S F S G ++P S ++
Sbjct: 1286 ---TKETT--------------SEESRVFQSS--------GWLSPHS--------FVESA 1312
Query: 258 ISSVWKEPISFV-VTHLRPYTTYLFEVSAATTEAGYIDSTIV--RTPESVPEG--PPQNC 312
+ K P + +T L PYT Y F V A AG + S V RT ES P PP
Sbjct: 1313 NENALKPPQTMTTITGLEPYTKYEFRV-LAVNMAGSVSSAWVSERTGESAPVFMIPPS-- 1369
Query: 313 VTGNITGKSFSILWDPP--TIVTGK-FSYRVELYGP-----------SGRILDNSTKDLK 358
++ S +I W+ P + GK Y + + S + +++L
Sbjct: 1370 -VFPLSSYSLNISWEKPADNVTRGKVVGYDINMLSEQSPQQSIPMAFSQLLHTAKSQELS 1428
Query: 359 FAFTNLTPFTMYDVYIAAETSAGTGPKSNISVFTPPDVPGAVFDLQLAEVESTQVRITWK 418
+ L P+ +Y+ I S G ++ + T P + + + ST + + W
Sbjct: 1429 YTVEGLKPYRIYEFTITLCNSVGCVTSASGAGQTLAAAPAQLRPPLVKGINSTTIHLKWF 1488
Query: 419 KPRQPNG 425
P + NG
Sbjct: 1489 PPEELNG 1495
Score = 65.9 bits (159), Expect = 5e-10
Identities = 74/317 (23%), Positives = 123/317 (38%), Gaps = 53/317 (16%)
Query: 528 QLSYVIRRLVPFTEHMISVSAFTIMGEGPPTVLSVRTRQQVPSSIKIINYKNISSSSILL 587
+ S I LVPF ++ SV A T G ++V T Q P + + ISS+ + +
Sbjct: 1202 ETSATIWNLVPFAKYDFSVQACTSGGCLHSLPITVTTAQAPPQRLSPPKMQKISSTELHV 1261
Query: 588 YWDPPEYPNGKITHYTIYAMEL--------DTNRAFQIT--TIDNSFL------------ 625
W PP NG I Y +Y L + +R FQ + +SF+
Sbjct: 1262 EWSPPAELNGIIIRYELYMRRLRSTKETTSEESRVFQSSGWLSPHSFVESANENALKPPQ 1321
Query: 626 ----ITGLKKYTKYKMRVAASTHVGESSLSEENDIFVRTSEDEPESSPQDVEVIDVTADE 681
ITGL+ YTKY+ RV A G S + ++ RT E P V +++
Sbjct: 1322 TMTTITGLEPYTKYEFRVLAVNMAGSVSSAWVSE---RTGESAPVFMIPP-SVFPLSSYS 1377
Query: 682 IRLKWSPP--EKPNGIIIAYEVLYKNIDT------------LYMKNTSTTDIILRNLRPH 727
+ + W P G ++ Y++ + + L+ + + L+P+
Sbjct: 1378 LNISWEKPADNVTRGKVVGYDINMLSEQSPQQSIPMAFSQLLHTAKSQELSYTVEGLKPY 1437
Query: 728 TLYNISVRSYTRFGHGNQVSSLLSVRTSETVPDSAPENI---TYKNISSGEIELSFLPPS 784
+Y ++ N V + S + +AP + K I+S I L + PP
Sbjct: 1438 RIYEFTITLC------NSVGCVTSASGAGQTLAAAPAQLRPPLVKGINSTTIHLKWFPPE 1491
Query: 785 SPNGIIQKYTIYLKRSN 801
NG Y + + S+
Sbjct: 1492 ELNGPSPIYQLERRESS 1508
Score = 64.7 bits (156), Expect = 1e-09
Identities = 95/419 (22%), Positives = 159/419 (37%), Gaps = 74/419 (17%)
Query: 1352 SWQSVLVKWDPPKKANGIITQYMVTVERNSTKVSPQDHMYTF-----IKLLANTSYVFKV 1406
S ++ + W PP N Y + + + + Y+ LL T Y + +
Sbjct: 1066 SSSAINLSWSPPDSPNAHWLTYSLLRDGFEIYTTEDQYPYSIQYFLDTDLLPYTKYSYYI 1125
Query: 1407 RASTSAGEGDESTCHVSTLPETVPSVPT-NIAFS---DVQSTSATLTWIRPDTILGYFQN 1462
+ G ST V+ +T P VP N+ S + S S TLTW G +
Sbjct: 1126 ETTNVHG----STRSVAVTYKTKPGVPEGNLTLSYIIPIGSDSVTLTWTTLSNQSGPIEK 1181
Query: 1463 YKITTQLRAQKCKEWESEECVEYQKIQYLYEAHLTEETVYGLKKFRWYRFQVAASTNAGY 1522
Y ++ A + CV Y E H T T++ L F Y F V A T+ G
Sbjct: 1182 YILSCAPLAG------GQPCVSY-------EGHETSATIWNLVPFAKYDFSVQACTSGGC 1228
Query: 1523 GNASNWISTKTLPGPPD--GPPENVHVVATSPFSISISWSEPAVITGPTC-------YLI 1573
+ S I+ T PP PP+ + +T + + WS PA + G L
Sbjct: 1229 LH-SLPITVTTAQAPPQRLSPPKMQKISST---ELHVEWSPPAELNGIIIRYELYMRRLR 1284
Query: 1574 DVKSVDNDEFNI----------SFIKSNEEN------KTIEIKDLEIFTRYS--VVITAF 1615
K ++E + SF++S EN I LE +T+Y V+
Sbjct: 1285 STKETTSEESRVFQSSGWLSPHSFVESANENALKPPQTMTTITGLEPYTKYEFRVLAVNM 1344
Query: 1616 TGNISAAYVE---GKSSAEMIVTTLESAPKDPPNNMTFQKIPDEVTKFQLTFLPPSQPNG 1672
G++S+A+V G+S+ ++ N++++K D VT+ G
Sbjct: 1345 AGSVSSAWVSERTGESAPVFMIPPSVFPLSSYSLNISWEKPADNVTR------------G 1392
Query: 1673 NIQVYQALVYREDDP-TAVQIHNLSIIQKTNTFVIA-MLEGLKGGHTYNISVYAVNSAG 1729
+ Y + E P ++ + ++ + ++ +EGLK Y ++ NS G
Sbjct: 1393 KVVGYDINMLSEQSPQQSIPMAFSQLLHTAKSQELSYTVEGLKPYRIYEFTITLCNSVG 1451
Score = 59.3 bits (142), Expect = 4e-08
Identities = 94/450 (20%), Positives = 158/450 (35%), Gaps = 73/450 (16%)
Query: 268 FVVTHLRPYTTYLFEVSAATTEAGYIDSTIV-RTPESVPEGPPQNCVTGNITGKSFSILW 326
F+ T L PYT Y + + + +T VPEG I S ++ W
Sbjct: 1110 FLDTDLLPYTKYSYYIETTNVHGSTRSVAVTYKTKPGVPEGNLTLSYIIPIGSDSVTLTW 1169
Query: 327 DPPTIVTGKFSYRVELYGPSGR---ILDNSTKDLKFAFTNLTPFTMYDVYIAAETSAGTG 383
+ +G + P + + NL PF YD + A TS G
Sbjct: 1170 TTLSNQSGPIEKYILSCAPLAGGQPCVSYEGHETSATIWNLVPFAKYDFSVQACTSGGCL 1229
Query: 384 PKSNISVFTPPDVPGAVFDLQLAEVESTQVRITWKKPRQPNGIINQYRVKVLVPETGIIL 443
I+V T P + ++ ++ ST++ + W P + NGII +Y L
Sbjct: 1230 HSLPITVTTAQAPPQRLSPPKMQKISSTELHVEWSPPAELNGIIIRYE-----------L 1278
Query: 444 ENTLLTGNNEYINDPMAPEIVNIVEPMVGLYEGSAEMSSDLHSLATFIYNSHPDKNFPAR 503
L E ++ E SS S +F+ +++ + P
Sbjct: 1279 YMRRLRSTKETTSE-----------------ESRVFQSSGWLSPHSFVESANENALKP-- 1319
Query: 504 NRAEDQTSPVVTTRNQYITDIAAEQLSYVIRRLVPFTEHMISVSAFTIMGEGPPTVLSVR 563
QT +T Y T++ V A + G +S R
Sbjct: 1320 ----PQTMTTITGLEPY-------------------TKYEFRVLAVNMAGSVSSAWVSER 1356
Query: 564 TRQQVPSSIKIINYKNISSSSILLYWDPP--EYPNGKITHYTIYAMELDTNR-----AFQ 616
T + P + + +SS S+ + W+ P GK+ Y I + + + AF
Sbjct: 1357 TGESAPVFMIPPSVFPLSSYSLNISWEKPADNVTRGKVVGYDINMLSEQSPQQSIPMAFS 1416
Query: 617 -----ITTIDNSFLITGLKKYTKYKMRVAASTHVGESSLSEENDIFVRTSEDEPESSPQD 671
+ + S+ + GLK Y Y+ + VG ++ + + + P
Sbjct: 1417 QLLHTAKSQELSYTVEGLKPYRIYEFTITLCNSVG--CVTSASGAGQTLAAAPAQLRPPL 1474
Query: 672 VEVIDVTADEIRLKWSPPEKPNGIIIAYEV 701
V+ I+ T I LKW PPE+ NG Y++
Sbjct: 1475 VKGINSTT--IHLKWFPPEELNGPSPIYQL 1502
Score = 54.7 bits (130), Expect = 1e-06
Identities = 52/211 (24%), Positives = 90/211 (42%), Gaps = 35/211 (16%)
Query: 16 ETQVDVSNVVPGTRYDITISSIST---TYTSPVTRIVTTNVTKP---GPPVFLAGERVGS 69
ET + N+VP +YD ++ + ++ ++ P+T VTT P PP +++ S
Sbjct: 1202 ETSATIWNLVPFAKYDFSVQACTSGGCLHSLPIT--VTTAQAPPQRLSPPKM---QKISS 1256
Query: 70 AGILLSWNTPPNPNGRIISYIVKYKEVCPWMQTVYTQVRS-------------------- 109
+ + W+ P NG II Y + + + +T + R
Sbjct: 1257 TELHVEWSPPAELNGIIIRYELYMRRLRSTKETTSEESRVFQSSGWLSPHSFVESANENA 1316
Query: 110 -KPDSLEVLLTNLNPGTTYEIKVAAENSAGIGVFSDPFLFQTAESAPGKVVNLTVEAYNA 168
KP +T L P T YE +V A N AG V S +T ESAP ++ +V ++
Sbjct: 1317 LKPPQTMTTITGLEPYTKYEFRVLAVNMAG-SVSSAWVSERTGESAPVFMIPPSVFPLSS 1375
Query: 169 SAVKLIWYLPRQ--PNGKITSFKISVKHARS 197
++ + W P GK+ + I++ +S
Sbjct: 1376 YSLNISWEKPADNVTRGKVVGYDINMLSEQS 1406
Score = 46.6 bits (109), Expect = 3e-04
Identities = 40/178 (22%), Positives = 77/178 (43%), Gaps = 13/178 (7%)
Query: 16 ETQVDVSNVVPGTRYDITISSISTTYTSPVTRIVTTNVTKPGPPVFLAGERV---GSAGI 72
+T ++ + P T+Y+ + +++ V+ + T PVF+ V S +
Sbjct: 1321 QTMTTITGLEPYTKYEFRVLAVNMA--GSVSSAWVSERTGESAPVFMIPPSVFPLSSYSL 1378
Query: 73 LLSWNTPPN--PNGRIISYIVKYKEVCPWMQTV---YTQV--RSKPDSLEVLLTNLNPGT 125
+SW P + G+++ Y + Q++ ++Q+ +K L + L P
Sbjct: 1379 NISWEKPADNVTRGKVVGYDINMLSEQSPQQSIPMAFSQLLHTAKSQELSYTVEGLKPYR 1438
Query: 126 TYEIKVAAENSAGIGVFSDPFLFQTAESAPGKVVNLTVEAYNASAVKLIWYLPRQPNG 183
YE + NS G V S QT +AP ++ V+ N++ + L W+ P + NG
Sbjct: 1439 IYEFTITLCNSVGC-VTSASGAGQTLAAAPAQLRPPLVKGINSTTIHLKWFPPEELNG 1495
>gi|148539860 protein tyrosine phosphatase, receptor type, T isoform 2
precursor [Homo sapiens]
Length = 1441
Score = 259 bits (661), Expect = 3e-68
Identities = 248/927 (26%), Positives = 397/927 (42%), Gaps = 142/927 (15%)
Query: 1429 VPSVPTNIAFSDVQSTSATLTWIRPDT--------ILGYFQNYKITTQLRAQKCKEWESE 1480
V PT IA ++ + AT WI+P+ I+ Y+ TT W
Sbjct: 285 VKEPPTPIAPPELLAVGATYLWIKPNANSIIGDGPIILKEVEYRTTTGT-------WAET 337
Query: 1481 ECVEYQKIQYLYEAHLTEETVYGLKKFRWYRFQVAASTNAGYGNASNWISTKTLPGPPDG 1540
V+ + HL + Y + R + G G ++T+T P
Sbjct: 338 HIVDSPNYKLW---HLDPDVEYEI------RVLLTRPGEGGTGPPGPPLTTRTKCADPVH 388
Query: 1541 PPENVHVVATSPFSISISWSEPAVITGPTCYLIDVKSVDNDEFNISFIKSNEENKTIEIK 1600
P+NV +V +++ W EP C+ ++ FN ++ E +T
Sbjct: 389 GPQNVEIVDIRARQLTLQW-EPFGYAVTRCHSYNLTVQYQYVFNQQQYEAEEVIQTSSHY 447
Query: 1601 DLEIFTRYSVVITAFTGNISAAYVEGK-SSAEMIVTTLESAPKDPPNNMTFQKIPDEVTK 1659
L + + + + EG+ S E++V T E P P + Q P E K
Sbjct: 448 TLRGLRPFMTIRL----RLLLSNPEGRMESEELVVQTEEDVPGAVPLE-SIQGGPFE-EK 501
Query: 1660 FQLTFLPPSQPNGNIQVYQALVYRED---DPTAVQIHNLSIIQKTNTFVIAMLEGLKGGH 1716
+ + PP++ NG I +Y+ + Y+ DP+A + K + GL G
Sbjct: 502 IYIQWKPPNETNGVITLYE-INYKAVGSLDPSADLSSQRGKVFKLRNETHHLFVGLYPGT 560
Query: 1717 TYNISVYAVNSAGAGPKVPMRITMDIKAPARPKTKPTPIYDATGKLLVTSTTITIRMPIC 1776
TY+ ++ A + G GP V RI I AP+ P+ YD L T TTIT+ +
Sbjct: 561 TYSFTIKASTAKGFGPPVTTRIATKISAPSMPE------YDTDTPLNETDTTITVMLKPA 614
Query: 1777 YYSDDHGPIKNVQVLVTETGAQHDGNVTKWYDAY-----FNKARP-----YFTNEGFP-N 1825
P+ Q++V E Q + + + A YF E P N
Sbjct: 615 --QSRGAPVSVYQLVVKEERLQKSRRAADIIECFSVPVSYRNASSLDSLHYFAAELKPAN 672
Query: 1826 PPCTEGKTKFSGNEEIYIIGADNACMIPGNEDKICNGPLKPKKQYLFKFRATNIMGQFT- 1884
P T+ T G+ + Y + N PL P K Y F+A + T
Sbjct: 673 LPVTQPFTV--GDNKTY--------------NGYWNPPLSPLKSYSIYFQALSKANGETK 716
Query: 1885 --------------DSDYSDPVKTLGEGLSERTVEIILSVT-LCILSIILLGTAIFA--- 1926
+S+ +P K + + TV++ + L + IILLG +
Sbjct: 717 INCVRLATKGASTQNSNTVEPEKQV-----DNTVKMAGVIAGLLMFIIILLGVMLTIKRR 771
Query: 1927 --------FARIRQKQKEGGTYSPQD------AEIIDTKLKLDQ--------------LI 1958
+ ++ +KQKE + + ++ A+ TKL +
Sbjct: 772 RNAYSYSYYLKLAKKQKETQSGAQREMGPVASADKPTTKLSASRNDEGFSSSSQDVNGFT 831
Query: 1959 TVADLELKDERLTRLLSYRKSIKPISKK-------------SFLQHVEELCTNNNLKFQE 2005
+ EL LT ++ P+ LQH+ ++ F+E
Sbjct: 832 DGSRGELSQPTLTIQTHPYRTCDPVEMSYPRDQFQPAIRVADLLQHITQMKRGQGYGFKE 891
Query: 2006 EFSELPKFLQDLSSTDADLPWNRAKNRFPNIKPYNNNRVKLIADASVPGSDYINASYISG 2065
E+ LP+ Q S A NR KNR+ NI Y+++RV+L+ P SDYINA+YI G
Sbjct: 892 EYEALPEG-QTASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYIDG 950
Query: 2066 YLCPNEFIATQGPLPGTVGDFWRMVWETRAKTLVMLTQCFEKGRIRCHQYWPEDNKPVTV 2125
Y P +IATQGP+ TV DFWRM+W+ + ++VM+T E GR++C +YWP+D + V
Sbjct: 951 YHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWPDDTE---V 1007
Query: 2126 FGDIVITKLMEDVQIDWTIRDLKIERHG--DCMTVRQCNFTAWPEHGVPENSAPLIHFVK 2183
+GDI +T + + ++ IR +++ G + +R +FT+WP+HGVP + L+ FV+
Sbjct: 1008 YGDIKVTLIETEPLAEYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCYATGLLGFVR 1067
Query: 2184 LVRASRAHDTTPMIVHCSAGVGRTGVFIALDHLTQHINDHDFVDIYGLVAELRSERMCMV 2243
V+ + P++VHCSAG GRTG FIA+D + + VDI+ V ELR++R+ +V
Sbjct: 1068 QVKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLV 1127
Query: 2244 QNLAQYIFLHQCILDLLSNKGSNQPIC 2270
Q QY+F+H IL+ + P+C
Sbjct: 1128 QTEEQYVFVHDAILEACLCGNTAIPVC 1154
Score = 111 bits (277), Expect = 9e-24
Identities = 83/277 (29%), Positives = 135/277 (48%), Gaps = 20/277 (7%)
Query: 1999 NNLKFQEEFSELPKFLQDLSSTDAD---LPWNRAKNRFPNIKPYNNNRVKLIADASVPG- 2054
N+ + ++EF L + D LP N KNR ++ P + LI SV G
Sbjct: 1171 NSSQIKDEFQTLNIVTPRVRPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLI---SVDGE 1227
Query: 2055 -SDYINASYISGYLCPNEFIATQGPLPGTVGDFWRMVWETRAKTLVMLTQCFEKGRIRCH 2113
S+YINA+ + + P F+ TQ PLP TV DFWR+V++ ++VML + + + C
Sbjct: 1228 SSNYINAALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNE-MDTAQF-CM 1285
Query: 2114 QYWPEDNKPVTVFGDIVITKLMEDVQIDWTIRDLKI----ERHGDCMTVRQCNFTAWPEH 2169
QYWPE K +G I + + D+ D R +I V+ + WP +
Sbjct: 1286 QYWPE--KTSGCYGPIQVEFVSADIDEDIIHRIFRICNMARPQDGYRIVQHLQYIGWPAY 1343
Query: 2170 -GVPENSAPLIHFV-KLVRASRAHDTTP--MIVHCSAGVGRTGVFIALDHLTQHINDHDF 2225
P + L+ V +L + +D +VHC G GR+G F A+ + + I +
Sbjct: 1344 RDTPPSKRSLLKVVRRLEKWQEQYDGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNI 1403
Query: 2226 VDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLLSN 2262
+D++ +V LR+ + MV+ L QY F+++ L+ LS+
Sbjct: 1404 IDVFHIVKTLRNNKSNMVETLEQYKFVYEVALEYLSS 1440
Score = 73.9 bits (180), Expect = 2e-12
Identities = 89/404 (22%), Positives = 155/404 (38%), Gaps = 55/404 (13%)
Query: 515 TTRNQYITDIAAEQLSYVIRRLVPFTEHMISVSAFTIMGEG------PPTVLSVRTRQQV 568
TT + + +Y + L P E+ I V T GEG PP + V
Sbjct: 329 TTTGTWAETHIVDSPNYKLWHLDPDVEYEIRV-LLTRPGEGGTGPPGPPLTTRTKCADPV 387
Query: 569 --PSSIKIINYKNISSSSILLYWDPPEYPNGKITHYTI-----YAMELDTNRAFQITTID 621
P +++I++ I + + L W+P Y + Y + Y A ++
Sbjct: 388 HGPQNVEIVD---IRARQLTLQWEPFGYAVTRCHSYNLTVQYQYVFNQQQYEAEEVIQTS 444
Query: 622 NSFLITGLKKYTKYKMRVAASTHVGESSLSEENDIFVRTSEDEPESSPQDVEVIDVTADE 681
+ + + GL+ + ++R+ S G E ++ V+T ED P + P + ++
Sbjct: 445 SHYTLRGLRPFMTIRLRLLLSNPEGRM---ESEELVVQTEEDVPGAVPLESIQGGPFEEK 501
Query: 682 IRLKWSPPEKPNGIIIAYEVLYKNIDTL------------YMKNTSTTDIILRNLRPHTL 729
I ++W PP + NG+I YE+ YK + +L K + T + L P T
Sbjct: 502 IYIQWKPPNETNGVITLYEINYKAVGSLDPSADLSSQRGKVFKLRNETHHLFVGLYPGTT 561
Query: 730 YNISVRSYTRFGHGNQVSSLLSVRTSETVPDSAPE--NITYKNISSGEIELSFLPPSSPN 787
Y+ ++++ T G G V++ ++ + S S PE T N + I + P S
Sbjct: 562 YSFTIKASTAKGFGPPVTTRIATKIS---APSMPEYDTDTPLNETDTTITVMLKPAQSRG 618
Query: 788 GIIQKYTIYLKRSNGNEERTINTTSLTQNIKVLKKYTQYIIEVSASTLKGEGVRSAPISI 847
+ Y + +K EER + I+ Y S +L P ++
Sbjct: 619 APVSVYQLVVK-----EERLQKSRRAADIIECFSVPVSYRNASSLDSLHYFAAELKPANL 673
Query: 848 LTEEDAPDSPPQDFSVKQLSGVTVKLSWQPPLEPNGIILYYTVY 891
Q F+V T W PPL P + Y++Y
Sbjct: 674 --------PVTQPFTVG--DNKTYNGYWNPPLSP---LKSYSIY 704
Score = 61.2 bits (147), Expect = 1e-08
Identities = 75/309 (24%), Positives = 128/309 (41%), Gaps = 41/309 (13%)
Query: 1175 VKPN-------GAIISYDL---TLQGPNENYSFITSDNYIILEELSPFTLYSFFAAARTR 1224
+KPN G II ++ T G + S NY L L P Y TR
Sbjct: 307 IKPNANSIIGDGPIILKEVEYRTTTGTWAETHIVDSPNYK-LWHLDPDVEYEI-RVLLTR 364
Query: 1225 KGLG----PSSILFFYTDESVPLAPPQNLTLINCTSDFVWLKWSPSPLPGGIVKVYSFKI 1280
G G P L T + P+ PQN+ +++ + + L+W P + + +S+ +
Sbjct: 365 PGEGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQWEPFGY--AVTRCHSYNL 422
Query: 1281 ---HEHETDTIYYKNISGFKTEAK--LVGLEPVSTYSIRVSAFTKVGNGNQFSNVVKFTT 1335
+++ + Y+ +T + L GL P T +R+ G VV+ T
Sbjct: 423 TVQYQYVFNQQQYEAEEVIQTSSHYTLRGLRPFMTIRLRLLLSNPEGRMESEELVVQ--T 480
Query: 1336 QESVPDVVQNMQCMATSWQS-VLVKWDPPKKANGIITQYMVTVER-----NSTKVSPQ-- 1387
+E VP V ++ + ++W PP + NG+IT Y + + S +S Q
Sbjct: 481 EEDVPGAVPLESIQGGPFEEKIYIQWKPPNETNGVITLYEINYKAVGSLDPSADLSSQRG 540
Query: 1388 -------DHMYTFIKLLANTSYVFKVRASTSAGEGDESTCHVSTLPETVPSVPTNIAFSD 1440
+ + F+ L T+Y F ++AST+ G G T ++T + PS+P +
Sbjct: 541 KVFKLRNETHHLFVGLYPGTTYSFTIKASTAKGFGPPVTTRIAT-KISAPSMPEYDTDTP 599
Query: 1441 VQSTSATLT 1449
+ T T+T
Sbjct: 600 LNETDTTIT 608
Score = 57.0 bits (136), Expect = 2e-07
Identities = 42/156 (26%), Positives = 66/156 (42%), Gaps = 13/156 (8%)
Query: 1140 QLYIKTEEDVPETSPIINTFKNLSSTSVLLSWDPPVKPNGAIISYDLTLQG-----PNEN 1194
+L ++TEEDVP P+ + + + W PP + NG I Y++ + P+ +
Sbjct: 475 ELVVQTEEDVPGAVPLESIQGGPFEEKIYIQWKPPNETNGVITLYEINYKAVGSLDPSAD 534
Query: 1195 YSF-------ITSDNYIILEELSPFTLYSFFAAARTRKGLGPSSILFFYTDESVPLAPPQ 1247
S + ++ + + L P T YSF A T KG GP T S P P
Sbjct: 535 LSSQRGKVFKLRNETHHLFVGLYPGTTYSFTIKASTAKGFGPPVTTRIATKISAPSMPEY 594
Query: 1248 NL-TLINCTSDFVWLKWSPSPLPGGIVKVYSFKIHE 1282
+ T +N T + + P+ G V VY + E
Sbjct: 595 DTDTPLNETDTTITVMLKPAQSRGAPVSVYQLVVKE 630
Score = 48.1 bits (113), Expect = 1e-04
Identities = 80/370 (21%), Positives = 143/370 (38%), Gaps = 31/370 (8%)
Query: 837 GEGVRSAPISILTEEDAPDSPPQDFSVKQLSGVTVKLSWQPPLEPNGIILYYTVYVWNRS 896
G GV + I+ E P +PP+ +V + + +K + + IIL Y
Sbjct: 274 GSGVSNYAELIVKEPPTPIAPPELLAVGA-TYLWIKPNANSIIGDGPIILKEVEYRTTTG 332
Query: 897 SLKTINVTET-SLELSDLDYNVEYSAYVTASTRFGDGKTR--SNIISFQTPEGAPSDPPK 953
+ ++ ++ + +L LD +VEY V TR G+G T ++ +T P P+
Sbjct: 333 TWAETHIVDSPNYKLWHLDPDVEYEIRVLL-TRPGEGGTGPPGPPLTTRTKCADPVHGPQ 391
Query: 954 DVYYANLSSSSIILFWTPPSKPNGIIQYYSVYYRNTSGTFMQNFTLHEVTNDFDNMTVST 1013
+V ++ + + L W P Y++ + Q + EV + T+
Sbjct: 392 NVEIVDIRARQLTLQWEPFGYAVTRCHSYNLTVQYQYVFNQQQYEAEEVIQTSSHYTLRG 451
Query: 1014 IIDKLTIFSYYTFWLTASTSVGNGNKSSDIIEVYTDQDIPEGFVGNLTYESISS----TA 1069
+ +TI L S G S+ + V T++D+P G + ESI
Sbjct: 452 LRPFMTIR------LRLLLSNPEGRMESEELVVQTEEDVP----GAVPLESIQGGPFEEK 501
Query: 1070 INVSWVPPAQPNGLVFYY---------VSLILQQTPRHVRPPLVTYERSIYFDNLEKYTD 1120
I + W PP + NG++ Y + + + + + E F L T
Sbjct: 502 IYIQWKPPNETNGVITLYEINYKAVGSLDPSADLSSQRGKVFKLRNETHHLFVGLYPGTT 561
Query: 1121 YILKITPSTEKGFSDTYTAQLYIK-TEEDVPETSPIINTFKNLSSTSVLLSWDPPVKPNG 1179
Y I ST KGF T ++ K + +PE +T N + T++ + P
Sbjct: 562 YSFTIKASTAKGFGPPVTTRIATKISAPSMPEYD--TDTPLNETDTTITVMLKPAQSRGA 619
Query: 1180 AIISYDLTLQ 1189
+ Y L ++
Sbjct: 620 PVSVYQLVVK 629
Score = 46.6 bits (109), Expect = 3e-04
Identities = 51/191 (26%), Positives = 74/191 (38%), Gaps = 26/191 (13%)
Query: 255 QNEISSVWKEPISFVVTHLRPYTTYLFEVSAATTEAGYIDST--IVRTPESVPEGPPQNC 312
Q E V + + + LRP+ T + + E G ++S +V+T E VP P
Sbjct: 434 QYEAEEVIQTSSHYTLRGLRPFMTIRLRLLLSNPE-GRMESEELVVQTEEDVPGAVPLES 492
Query: 313 VTGNITGKSFSILWDPPTIVTG-----KFSYR--------VELYGPSGRI--LDNSTKDL 357
+ G + I W PP G + +Y+ +L G++ L N T L
Sbjct: 493 IQGGPFEEKIYIQWKPPNETNGVITLYEINYKAVGSLDPSADLSSQRGKVFKLRNETHHL 552
Query: 358 KFAFTNLTPFTMYDVYIAAETSAGTGPKSNISVFT---PPDVPGAVFDLQLAEVESTQVR 414
F L P T Y I A T+ G GP + T P +P D L E ++T
Sbjct: 553 ---FVGLYPGTTYSFTIKASTAKGFGPPVTTRIATKISAPSMPEYDTDTPLNETDTTIT- 608
Query: 415 ITWKKPRQPNG 425
KP Q G
Sbjct: 609 -VMLKPAQSRG 618
Score = 38.5 bits (88), Expect = 0.077
Identities = 36/146 (24%), Positives = 58/146 (39%), Gaps = 16/146 (10%)
Query: 299 RTPESVPEGPPQNCVTGNITGKSFSILWDP-PTIVTGKFSYRVELYGP---------SGR 348
RT + P PQN +I + ++ W+P VT SY + + +
Sbjct: 380 RTKCADPVHGPQNVEIVDIRARQLTLQWEPFGYAVTRCHSYNLTVQYQYVFNQQQYEAEE 439
Query: 349 ILDNSTKDLKFAFTNLTPFTMYDVYIAAETSAGTGPKSNISVFTPPDVPGAV--FDLQLA 406
++ S+ + L PF + + G + V T DVPGAV +Q
Sbjct: 440 VIQTSSH---YTLRGLRPFMTIRLRLLLSNPEGRMESEELVVQTEEDVPGAVPLESIQGG 496
Query: 407 EVESTQVRITWKKPRQPNGIINQYRV 432
E ++ I WK P + NG+I Y +
Sbjct: 497 PFEE-KIYIQWKPPNETNGVITLYEI 521
Score = 33.1 bits (74), Expect = 3.2
Identities = 21/74 (28%), Positives = 29/74 (39%), Gaps = 5/74 (6%)
Query: 72 ILLSWNTPPNPNGRIISYIVKYKEVCPW-----MQTVYTQVRSKPDSLEVLLTNLNPGTT 126
I + W P NG I Y + YK V + + +V + L L PGTT
Sbjct: 502 IYIQWKPPNETNGVITLYEINYKAVGSLDPSADLSSQRGKVFKLRNETHHLFVGLYPGTT 561
Query: 127 YEIKVAAENSAGIG 140
Y + A + G G
Sbjct: 562 YSFTIKASTAKGFG 575
>gi|148728162 protein tyrosine phosphatase, receptor type, J isoform 1
precursor [Homo sapiens]
Length = 1337
Score = 256 bits (655), Expect = 1e-67
Identities = 288/1131 (25%), Positives = 463/1131 (40%), Gaps = 147/1131 (12%)
Query: 1184 YDLTLQGPNENYSFITS-DNYIILEELSPFTLYSFFAAARTRKGL-GPSSILFFYTDESV 1241
+D +L GP + S S D ++L L P T Y+ ++ G G + F T+
Sbjct: 309 HDESLVGPVDPSSGQQSRDTEVLLVGLEPGTRYNATVYSQAANGTEGQPQAIEFRTNAIQ 368
Query: 1242 PLAPPQNLTLINCTSDFVWLKWSPSPLPGGIVKVYSFKIH-EHETDTIYYKNISGFKTEA 1300
++T +N ++ + L W S Y++KIH ETD+ N++ + A
Sbjct: 369 VF----DVTAVNISATSLTLIWKVSDNESS--SNYTYKIHVAGETDS---SNLNVSEPRA 419
Query: 1301 KLVGLEPVSTYSIRVSAFTKVGNGNQFSNVVKFTTQESVPDVVQNMQCMATSWQSVLVKW 1360
+ GL + Y+I V F + P V + + S + + W
Sbjct: 420 VIPGLRSSTFYNITVCPVL-----GDIEGTPGFLQVHTPPVPVSDFRVTVVSTTEIGLAW 474
Query: 1361 DPPKKANGIITQYMVTVER--NSTKVSPQDHMYTFIKLLANTSYVFKVRASTSAG-EGDE 1417
+ Q +T E NS + L T Y F++ G EG
Sbjct: 475 SSHDAES---FQMHITQEGAGNSRVEITTNQSIIIGGLFPGTKYCFEIVPKGPNGTEGAS 531
Query: 1418 STCHVSTLPETVPSVPTNIAFSDVQSTSATLTWIRPDTILGYFQNYKITTQLRAQKCKEW 1477
T TVPS +I V +T L W PD Y + I ++ + +
Sbjct: 532 RT----VCNRTVPSAVFDIHVVYVTTTEMWLDWKSPDGASEYVYHLVIESKHGSNHTSTY 587
Query: 1478 ESEECVEYQKIQYLYEAHLTEETVYGLKKFRWYRFQVAASTNAGYGNASNWISTKTLPGP 1537
+ T+ GL Y ++ + +G+ + ST P
Sbjct: 588 DKAI------------------TLQGLIPGTLYNITISPEVDHVWGDPN---STAQYTRP 626
Query: 1538 PDGPPENVHVVATSPFSISISWSEPAVITGPTCYLIDVKSVDNDEFNISFIKSNEENKTI 1597
+ N+ V +T+ + ++SW + Y + ++ N N + + ++
Sbjct: 627 SN--VSNIDV-STNTTAATLSWQNFDDASPTYSYCLLIEKAGNSS-NATQVVTDIGITDA 682
Query: 1598 EIKDLEIFTRYSVVITAFTGNISAAYVEGKSS-----AEMIVTTLESAPKDPPNNMTFQK 1652
+ +L + Y+V I A G+ + G+ S A M E PK+P + +
Sbjct: 683 TVTELIPGSSYTVEIFAQVGDGIKSLEPGRKSFCTDPASMASFDCEVVPKEPALVLKWTC 742
Query: 1653 IPDEVTKFQLTFLPPSQPNGNIQVYQALVYREDDPTAVQIHNLSIIQKTNTFVIAMLEGL 1712
P F+L + N H S + T + L
Sbjct: 743 PPGANAGFELEVSSGAWNNAT-------------------HLESCSSENGTEYRTEVTYL 783
Query: 1713 KGGHTYNISVYAVNSAGAGPKVPMRITMDIKAPARPKTKPTPIYDATGKLLVTSTTI-TI 1771
+YNIS+ V+ T I P P P +TS + ++
Sbjct: 784 NFSTSYNISITTVSCGKMAAPTRNTCTTGITDPPPPDGSPN----------ITSVSHNSV 833
Query: 1772 RMPICYYSDDHGPIKNVQVLVTETGAQH-DGNVTKWYDAYFNKARP--YFT------NEG 1822
++ + HGPIK V++T A H +V K+ F K Y T +G
Sbjct: 834 KVKFSGFEASHGPIKAYAVILTTGEAGHPSADVLKYTYEDFKKGASDTYVTYLIRTEEKG 893
Query: 1823 FPNPPCTEGKTKFSGNEEIYIIGADNACMIPGNEDKIC-----NGPLKPKKQYLFKFRAT 1877
K + E +G N + P + C N P+ + L +
Sbjct: 894 RSQSLSEVLKYEIDVGNESTTLGYYNGKLEPLGSYRACVAGFTNITFHPQNKGLIDGAES 953
Query: 1878 NIMGQFTDSDYSDPVKTLGEGLSERTVEIILSVTLCILSIILLGTAIFAFARIRQKQKEG 1937
+ + S YSD V L + I +V CI +++ T + F R+K+K+
Sbjct: 954 YV----SFSRYSDAVS-----LPQDPGVICGAVFGCIFGALVIVT-VGGFIFWRKKRKDA 1003
Query: 1938 GTYSPQDAEIIDTKLKLDQLITVADLELKDERLTRLLSYRKSIKPISKKSFLQHVEELCT 1997
++I K KL I ++F + ++
Sbjct: 1004 KNNEVSFSQIKPKKSKL----------------------------IRVENFEAYFKKQQA 1035
Query: 1998 NNNLKFQEEFSELPKFLQDLSSTDADLPWNRAKNRFPNIKPYNNNRVKLIADASVPGSDY 2057
++N F EE+ +L A+L NR KNR+ N+ PY+ +RVKL DY
Sbjct: 1036 DSNCGFAEEYEDLKLVGISQPKYAAELAENRGKNRYNNVLPYDISRVKLSVQTHST-DDY 1094
Query: 2058 INASYISGYLCPNEFIATQGPLPGTVGDFWRMVWETRAKTLVMLTQCFEKGRIRCHQYWP 2117
INA+Y+ GY +FIATQGPLP T+ DFWRMVWE ++MLT+C E+GR +C +YWP
Sbjct: 1095 INANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWP 1154
Query: 2118 EDNKPVTVFGDIVITKLMEDVQIDWTIRDLKIE--RHGDCMTVRQCNFTAWPEHGVPENS 2175
+K +GDI + E V +WTIRD ++ + + +RQ +FT+WP+HGVP+ +
Sbjct: 1155 --SKQAQDYGDITVAMTSEIVLPEWTIRDFTVKNIQTSESHPLRQFHFTSWPDHGVPDTT 1212
Query: 2176 APLIHFVKLVR--ASRAHDTTPMIVHCSAGVGRTGVFIALDHLTQHINDHDFVDIYGLVA 2233
LI+F LVR ++ +P++VHCSAGVGRTG FIA+D L I + + VD+YG+V
Sbjct: 1213 DLLINFRYLVRDYMKQSPPESPILVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVY 1272
Query: 2234 ELRSERMCMVQNLAQYIFLHQCILDLL-SNKGSNQPICFVNYSALQKMDSL 2283
+LR R MVQ QY+FL+QC+LD++ S K S + + N +A+ ++L
Sbjct: 1273 DLRMHRPLMVQTEDQYVFLNQCVLDIVRSQKDSKVDLIYQNTTAMTIYENL 1323
Score = 52.0 bits (123), Expect = 7e-06
Identities = 104/445 (23%), Positives = 176/445 (39%), Gaps = 48/445 (10%)
Query: 554 EGPPTVLSVRTRQQVPSSIKIINYKNISSSSILLYWDPPEYPNGKITHYTIYAMELDTNR 613
EG P L V T P + +S++ I L W + + ++ H T E N
Sbjct: 442 EGTPGFLQVHTP---PVPVSDFRVTVVSTTEIGLAWSSHDAESFQM-HIT---QEGAGNS 494
Query: 614 AFQITTIDNSFLITGLKKYTKYKMRVAASTHVGESSLSEENDIFVRTSEDEPESSPQDVE 673
+ITT + S +I GL TKY + G S + RT S+ D+
Sbjct: 495 RVEITT-NQSIIIGGLFPGTKYCFEIVPKGPNGTEGASRT--VCNRTVP----SAVFDIH 547
Query: 674 VIDVTADEIRLKWSPPEKPNGIIIAYEVLYKNIDTLYMKNTSTTD--IILRNLRPHTLYN 731
V+ VT E+ L W P+ + + + K+ +TST D I L+ L P TLYN
Sbjct: 548 VVYVTTTEMWLDWKSPDGASEYVYHLVIESKHGSN----HTSTYDKAITLQGLIPGTLYN 603
Query: 732 ISVRSYTRFGHGNQVSSLLSVRTSETVPDSAPENITYKNISSGEIELSFLPPSSPNGIIQ 791
I++ G+ S+ R S N T +S + +SP
Sbjct: 604 ITISPEVDHVWGDPNSTAQYTRPSNVSNIDVSTNTTAATLSWQNFD-----DASPT---Y 655
Query: 792 KYTIYLKRSNGNEERTINTTSL---TQNIKVLKKYTQYIIEVSASTLKGEGVRS---API 845
Y + ++++ + T T + + L + Y +E+ A G+G++S
Sbjct: 656 SYCLLIEKAGNSSNATQVVTDIGITDATVTELIPGSSYTVEIFAQV--GDGIKSLEPGRK 713
Query: 846 SILTEEDAPDSPPQDFSVKQLSGVTVKLSWQ-PPLEPNGIILYYTVYVWNRS----SLKT 900
S T+ + S + K+ + V L W PP G L + WN + S +
Sbjct: 714 SFCTDPASMASFDCEVVPKEPALV---LKWTCPPGANAGFELEVSSGAWNNATHLESCSS 770
Query: 901 INVTETSLELSDLDYNVEYS-AYVTASTRFGDGKTRSNIISFQTPEGAPSDPPKDVYYAN 959
N TE E++ L+++ Y+ + T S TR+ + T P P +
Sbjct: 771 ENGTEYRTEVTYLNFSTSYNISITTVSCGKMAAPTRNTCTTGITDPPPPDGSPN---ITS 827
Query: 960 LSSSSIILFWTPPSKPNGIIQYYSV 984
+S +S+ + ++ +G I+ Y+V
Sbjct: 828 VSHNSVKVKFSGFEASHGPIKAYAV 852
Score = 45.8 bits (107), Expect = 5e-04
Identities = 59/293 (20%), Positives = 110/293 (37%), Gaps = 20/293 (6%)
Query: 1158 TFKNLSSTSVLLSWDPPVKPNGAIISYDLTLQGPNENYSFITSDNYIILEELSPFTLYSF 1217
T N+S+TS+ L W + + +Y + + G ++ + S+ ++ L T Y+
Sbjct: 373 TAVNISATSLTLIWKVSDNESSSNYTYKIHVAGETDSSNLNVSEPRAVIPGLRSSTFYNI 432
Query: 1218 FAAARTRKGLGPSSILFFYTDESVPLAPPQNLTLINCTSDFVWLKWSPSPLPGGIVKVYS 1277
G L +T P P + + ++ + L WS S
Sbjct: 433 TVCPVLGDIEGTPGFLQVHT----PPVPVSDFRVTVVSTTEIGLAWSSHDAE-------S 481
Query: 1278 FKIHEHETDTIYYKNISGFKTEAKLVGLEPVSTYSIRVSAFTKVGNGNQFSNVVKFTTQE 1337
F++H + + + GL P + Y + K NG + ++ +
Sbjct: 482 FQMHITQEGAGNSRVEITTNQSIIIGGLFPGTKYCFEI--VPKGPNGTEGAS--RTVCNR 537
Query: 1338 SVPDVVQNMQCMATSWQSVLVKWDPPKKANGIITQYMVTVERNSTKVSPQDHMYTFIKLL 1397
+VP V ++ + + + + W P A+ + ++ + S S D T L+
Sbjct: 538 TVPSAVFDIHVVYVTTTEMWLDWKSPDGASEYVYHLVIESKHGSNHTSTYDKAITLQGLI 597
Query: 1398 ANTSYVFKVRASTSAGEGDESTCHVSTLPETVPSVPTNIAFSDVQSTSATLTW 1450
T Y + GD + ST T PS +NI S +T+ATL+W
Sbjct: 598 PGTLYNITISPEVDHVWGDPN----STAQYTRPSNVSNIDVS-TNTTAATLSW 645
Score = 40.0 bits (92), Expect = 0.026
Identities = 129/670 (19%), Positives = 243/670 (36%), Gaps = 94/670 (14%)
Query: 569 PSSIKIINYKNISSSSILLYWDPPEYPNGKITHYTIYAMELDTNRAFQITTIDNSFL-IT 627
PS + I +IS ++++L W + + + + ME + IT + + IT
Sbjct: 119 PSPVFDIKAVSISPTNVILTWKSNDTAASEYKYVVKHKMENEKT----ITVVHQPWCNIT 174
Query: 628 GLKKYTKYKMRVAASTHVGESSLSEENDIFVRTSEDEPESSPQDVEVIDVTADEIRLKWS 687
GL+ T Y + +G + + I V T E P S D+ V + L WS
Sbjct: 175 GLRPATSYVFSITPG--IGNETWGDPRVIKVIT-EPIPVS---DLRVALTGVRKAALSWS 228
Query: 688 PPEKPNGIIIAYEVLYKNIDTLYMKNTSTTDIILRNLRPHTLYNIS---VRSYTRFGHGN 744
NG +L + S + + L+P YNI+ ++S G
Sbjct: 229 ---NGNGTASCRVLLESIGSHEELTQDSRLQVNISGLKPGVQYNINPYLLQSNKTKGDPL 285
Query: 745 QVSSLLSVRTSETVPDSAPENITYKNISSGEIELSFLPPSSPNGIIQKYTIYLKRSNGNE 804
L +E +P + S + P P S+G +
Sbjct: 286 GTEGGLDASNTERSRAGSPTAPVHDE--------SLVGPVDP-------------SSGQQ 324
Query: 805 ERTINTTSLTQNIKVLKKYTQYIIEVSASTLKGEGVRSAPISILTEEDAPDSPPQDFSVK 864
R +T L ++ +Y + +A+ +G+ P +I +A D +
Sbjct: 325 SR--DTEVLLVGLEPGTRYNATVYSQAANGTEGQ-----PQAIEFRTNAIQV--FDVTAV 375
Query: 865 QLSGVTVKLSWQPPLEPNGIILYYTVYVWNRSSLKTINVTETSLELSDLDYNVEYSAYVT 924
+S ++ L W+ + Y ++V + +NV+E + L + Y+ +T
Sbjct: 376 NISATSLTLIWKVSDNESSSNYTYKIHVAGETDSSNLNVSEPRAVIPGLRSSTFYN--IT 433
Query: 925 ASTRFGDGKTRSNIISFQTPEGAPSDPPKDVYYANLSSSSIILFWTPPSKPNGIIQYYSV 984
GD + + TP P D +S++ I L W+
Sbjct: 434 VCPVLGDIEGTPGFLQVHTPPV----PVSDFRVTVVSTTEIGLAWSS------------- 476
Query: 985 YYRNTSGTFMQNFTLHEVTNDFDNMTV--STIIDKLTIFSYYTFWLTASTSVGNGNKSSD 1042
+ + +F + T N +T S II L + Y F + G S
Sbjct: 477 ---HDAESFQMHITQEGAGNSRVEITTNQSIIIGGLFPGTKYCFEIVPKGPNGTEGASRT 533
Query: 1043 IIEVYTDQDIPEGFVGNLTYESISSTAINVSWVPPAQPNGLVFYYVSLILQQTPRHVRPP 1102
+ ++ +P V ++ +++T + + W P+G Y L+++ +H
Sbjct: 534 VC----NRTVPSA-VFDIHVVYVTTTEMWLDW---KSPDGASEYVYHLVIES--KHGSNH 583
Query: 1103 LVTYERSIYFDNLEKYTDYILKITPSTEKGFSDTYTAQLYIKTEEDVPETSPIINTFKNL 1162
TY+++I L T Y + I+P + + D + Y + S + N +
Sbjct: 584 TSTYDKAITLQGLIPGTLYNITISPEVDHVWGDPNSTAQYTR-------PSNVSNIDVST 636
Query: 1163 SSTSVLLSWDPPVKPNGAIISYDLTLQ--GPNENYSFITSDNYI---ILEELSPFTLYSF 1217
++T+ LSW SY L ++ G + N + + +D I + EL P + Y+
Sbjct: 637 NTTAATLSWQ-NFDDASPTYSYCLLIEKAGNSSNATQVVTDIGITDATVTELIPGSSYTV 695
Query: 1218 FAAARTRKGL 1227
A+ G+
Sbjct: 696 EIFAQVGDGI 705
Score = 37.4 bits (85), Expect = 0.17
Identities = 44/178 (24%), Positives = 75/178 (42%), Gaps = 27/178 (15%)
Query: 15 SETQVDVSNVVPGTRYDITISSISTTYTSPVTRIVTTNVTKPGPPVFLAGERVGSAGILL 74
S QV++S + PG +Y+I ++ +N TK G+ +G+ G L
Sbjct: 253 SRLQVNISGLKPGVQYNIN------------PYLLQSNKTK--------GDPLGTEGGLD 292
Query: 75 SWNTPPNPNGRIISYIVKYKEVCPWMQTVYTQVRSKPDSLEVLLTNLNPGTTYEIKVAAE 134
+ NT + G + + V P + Q R EVLL L PGT Y V ++
Sbjct: 293 ASNTERSRAGSPTAPVHDESLVGPVDPSSGQQSRDT----EVLLVGLEPGTRYNATVYSQ 348
Query: 135 NSAGIGVFSDPFLFQTAESAPGKVVNLTVEAYNASAVKLIWYLPRQPNGKITSFKISV 192
+ G F+T +V ++T +A+++ LIW + + ++KI V
Sbjct: 349 AANGTEGQPQAIEFRTNAI---QVFDVTAVNISATSLTLIWKVSDNESSSNYTYKIHV 403
Score = 35.4 bits (80), Expect = 0.65
Identities = 40/163 (24%), Positives = 67/163 (41%), Gaps = 17/163 (10%)
Query: 14 TSETQVDVSNVVPGTRYDITISSISTTYTSPVTRIVTTNVTKPGPPVFLAGERVGSAGIL 73
T+ + + + PGT+Y I T +R V N T P + V + +
Sbjct: 499 TTNQSIIIGGLFPGTKYCFEIVPKGPNGTEGASRTVC-NRTVPSAVFDIHVVYVTTTEMW 557
Query: 74 LSWNTPPNPNGRIISYIVKYKEVCPWMQTVYTQVRSKPDSLEVLLTNLNPGTTYEIKVAA 133
L W +P + + +++ K + +T K +L+ L+ PGT Y I ++
Sbjct: 558 LDWKSPDGASEYVYHLVIESKH-----GSNHTSTYDKAITLQGLI----PGTLYNITISP 608
Query: 134 ENSAGIGVFSDPFLFQTAE-SAPGKVVNLTVEAYNASAVKLIW 175
E V+ DP TA+ + P V N+ V N +A L W
Sbjct: 609 EVD---HVWGDP--NSTAQYTRPSNVSNIDVST-NTTAATLSW 645
>gi|109633041 protein tyrosine phosphatase, receptor type, F isoform 1
precursor [Homo sapiens]
Length = 1907
Score = 254 bits (650), Expect = 5e-67
Identities = 156/442 (35%), Positives = 241/442 (54%), Gaps = 17/442 (3%)
Query: 1861 NGPLKPKKQY----LFKFRATNIMGQFTDSDYSDPVKTLGEGLSERTVEIILSVTLCILS 1916
N PL P Y L + ++ S YSD + ++ +L VT +L+
Sbjct: 1211 NRPLSPDLSYQCFVLASLKEPMDQKRYASSPYSDEIVVQVTPAQQQEEPEMLWVTGPVLA 1270
Query: 1917 IILLGTAIFAFARIRQKQKEGGTYSPQDAEIIDTKLKLDQLITVADLELKDERLTRLLSY 1976
+IL+ + A ++K+ T+SP + LK D L+ + ++ RL
Sbjct: 1271 VILIILIVIAILLFKRKR----THSPSSKDEQSIGLK-DSLLAHSSDPVEMRRLNYQTPG 1325
Query: 1977 RKSIKPISKKSFLQHVEELCTNNNLKFQEEFSELPKFLQDLSSTDADLPWNRAKNRFPNI 2036
+ PI ++E L N+ LKF +E+ + Q + +++L N+ KNR+ N+
Sbjct: 1326 MRDHPPIPITDLADNIERLKANDGLKFSQEYESIDPG-QQFTWENSNLEVNKPKNRYANV 1384
Query: 2037 KPYNNNRVKLIADASVPGSDYINASYISGYLCPNEFIATQGPLPGTVGDFWRMVWETRAK 2096
Y+++RV L + VPGSDYINA+YI GY N +IATQGPLP T+GDFWRMVWE R
Sbjct: 1385 IAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTA 1444
Query: 2097 TLVMLTQCFEKGRIRCHQYWPEDNKPVTVFGDIVITKLMEDVQI-DWTIRDLKIERHG-- 2153
T+VM+T+ EK R++C QYWP + G I +T L++ V++ +T+R + + G
Sbjct: 1445 TVVMMTRLEEKSRVKCDQYWPA--RGTETCGLIQVT-LLDTVELATYTVRTFALHKSGSS 1501
Query: 2154 DCMTVRQCNFTAWPEHGVPENSAPLIHFVKLVRASRAHDTTPMIVHCSAGVGRTGVFIAL 2213
+ +RQ F AWP+HGVPE P++ F++ V+A D PM+VHCSAGVGRTG FI +
Sbjct: 1502 EKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVI 1561
Query: 2214 DHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLLSNKGSNQPICFVN 2273
D + + + VDIYG V +RS+R MVQ QY+F+H+ +L+ + + P +
Sbjct: 1562 DAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPARNL- 1620
Query: 2274 YSALQKMDSLDAMEGDVELEWE 2295
Y+ +QK+ + E +E E
Sbjct: 1621 YAHIQKLGQVPPGESVTAMELE 1642
Score = 212 bits (540), Expect = 3e-54
Identities = 206/807 (25%), Positives = 342/807 (42%), Gaps = 61/807 (7%)
Query: 581 SSSSILLYWDPPEYPNGKITHYTIYAMELDTNRAFQIT--TIDNSFLITGLKKYTKYKMR 638
+++S+ L WD + +T+Y I T FQ + I GL +++Y R
Sbjct: 331 TATSVTLTWDSGN--SEPVTYYGIQYRAAGTEGPFQEVDGVATTRYSIGGLSPFSEYAFR 388
Query: 639 VAASTHVGESSLSEENDIFVRTSEDEPESSPQDVEVIDVTADEIRLKWSPPEKPNGIIIA 698
V A +G SE + RT E P S P+ V+ ++A + ++W PPE+PNG++
Sbjct: 389 VLAVNSIGRGPPSEA--VRARTGEQAPSSPPRRVQARMLSASTMLVQWEPPEEPNGLVRG 446
Query: 699 YEVLY----KNIDTLYMKNTSTTDII--LRNLRPHTLYNISVRSYTRFGHGNQVSSLLSV 752
Y V Y + + K+ + ++ + +L P Y++ V ++T G G S + V
Sbjct: 447 YRVYYTPDSRRPPNAWHKHNTDAGLLTTVGSLLPGITYSLRVLAFTAVGDGPP-SPTIQV 505
Query: 753 RTSETVPDSAPENITYKNISSGEIELSFLPPSSPNGIIQKYTIYLKRSNGNEERTINTTS 812
+T + VP + P + + S I+LS+L P I+ + + + + +
Sbjct: 506 KTQQGVP-AQPADFQAEVESDTRIQLSWLLPPQERIIMYELVYWAAEDEDQQHKVTFDPT 564
Query: 813 LTQNIKVLKKYTQYIIEVSASTLKGEGVRSAPISILTEEDAPDSPPQDFSVKQLSGVTVK 872
+ ++ LK T Y +++A + G GV + I T + P +PPQ + TV+
Sbjct: 565 SSYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVR 624
Query: 873 LSWQPPL--EPNGIILYYTVYV-------WNRSSLKTINVTETSLELSDLDYNVEYSAYV 923
+SW PP NG+I Y+V R + I+ +S +L L+ EY +V
Sbjct: 625 VSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISREHSSWDLVGLEKWTEYRVWV 684
Query: 924 TASTRFGDGKTRSNIISFQTPEGAPSDPPKDVYYANLSSSSIILFW--TPPSKPNGIIQY 981
A T G G S ++ +T E PS PP+ V L+S+++ ++W PSK +G I+
Sbjct: 685 RAHTDVGPGPESSPVL-VRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRG 743
Query: 982 YSV-YYRNTSG-----TFMQNFTLHEVT-NDFDNMTVSTIIDKLTIFSYYTFWLTASTSV 1034
Y V Y R +G +Q+ L E ++ T I LT + Y+ + A T+
Sbjct: 744 YQVTYVRLENGEPRGLPIIQDVMLAEAQWRPEESEDYETTISGLTPETTYSVTVAAYTTK 803
Query: 1035 GNGNKSSDIIEVYTDQDIPEGFVGNLTYESISSTAIN---VSWVPPAQ-PNGLVFYYVSL 1090
G+G +S I T G V IS+TA+N + W PP + P L+ Y +
Sbjct: 804 GDGARSKPKIVTTT------GAVPGRPTMMISTTAMNTALLQWHPPKELPGELLGYRLQY 857
Query: 1091 ILQQTPRHVRPPLVTYERSIYFDNLEKYTDYILKITPSTEKGFSDTYTAQLYIKTEEDVP 1150
R ++ L K T YI ++ G + + + I+T ED+P
Sbjct: 858 CRADEARPNTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEFEKE--IRTPEDLP 915
Query: 1151 ETSPIINTFKNLSSTSVLLSWDPPV--KPNGAIISYDLTLQGPNENYSF--ITSDNYIIL 1206
P L++++ L+WDPPV + NG IISY + + N IT+D L
Sbjct: 916 SGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRDINSQQELQNITTDTRFTL 975
Query: 1207 EELSPFTLYSFFAAARTRKGLGPSSILFFYTDESVPLAPPQNLTLINCTSDFVWLKWSPS 1266
L P T Y A T KG GP S V +N + V L W
Sbjct: 976 TGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVEQVFAKNFRVAAAMKTSVLLSWE-- 1033
Query: 1267 PLPGGIVKVYSFKIHEHETDTIYYKNISGFKTEAKLVGLEPVSTYSIRVSAFTKVGNGNQ 1326
+P FKI + + G + L+P + YS F + G+
Sbjct: 1034 -VPDSYKSAVPFKILYNGQSV----EVDGHSMRKLIADLQPNTEYS-----FVLMNRGSS 1083
Query: 1327 FSNVVKFTTQESVPDVVQNMQCMATSW 1353
+ + + PD++ + A+++
Sbjct: 1084 AGGLQHLVSIRTAPDLLPHKPLPASAY 1110
Score = 209 bits (533), Expect = 2e-53
Identities = 202/802 (25%), Positives = 328/802 (40%), Gaps = 56/802 (6%)
Query: 669 PQDVEVIDVTADEIRLKW-SPPEKPNGIIIAYEVLYKNIDT----LYMKNTSTTDIILRN 723
P D+ V + TA + L W S +P + Y + Y+ T + +TT +
Sbjct: 322 PIDLVVTETTATSVTLTWDSGNSEP---VTYYGIQYRAAGTEGPFQEVDGVATTRYSIGG 378
Query: 724 LRPHTLYNISVRSYTRFGHGNQVSSLLSVRTSETVPDSAPENITYKNISSGEIELSFLPP 783
L P + Y V + G G S + RT E P S P + + +S+ + + + PP
Sbjct: 379 LSPFSEYAFRVLAVNSIGRGPP-SEAVRARTGEQAPSSPPRRVQARMLSASTMLVQWEPP 437
Query: 784 SSPNGIIQKYTIYL---KRSNGNEERTINTTS-LTQNIKVLKKYTQYIIEVSASTLKGEG 839
PNG+++ Y +Y R N NT + L + L Y + V A T G+G
Sbjct: 438 EEPNGLVRGYRVYYTPDSRRPPNAWHKHNTDAGLLTTVGSLLPGITYSLRVLAFTAVGDG 497
Query: 840 VRSAPISILTEEDAPDSPPQDFSVKQLSGVTVKLSWQPPLEPNGIILYYTVYVWNRSSLK 899
S I + T++ P + P DF + S ++LSW P + II+Y VY +
Sbjct: 498 PPSPTIQVKTQQGVP-AQPADFQAEVESDTRIQLSWLLPPQER-IIMYELVYWAAEDEDQ 555
Query: 900 TINVT---ETSLELSDLDYNVEYSAYVTASTRFGDGKTRSNIISFQTPEGAPSDPPKDVY 956
VT +S L DL + Y + A + G G + I +T + PS PP+ V
Sbjct: 556 QHKVTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVG-VFTPTIEARTAQSTPSAPPQKVM 614
Query: 957 YANLSSSSIILFWTPP--SKPNGIIQYYSVYYRNTSGTFMQNFTLHEVTNDFDNMTVSTI 1014
++ S+++ + W PP NG+I YSV Y G + ++ + + +
Sbjct: 615 CVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISREHSSWDLVG- 673
Query: 1015 IDKLTIFSYYTFWLTASTSVGNGNKSSDIIEVYTDQDIPEGFVGNLTYESISSTAINVSW 1074
L ++ Y W+ A T VG G +SS ++ V TD+D+P G + E ++STA++V W
Sbjct: 674 ---LEKWTEYRVWVRAHTDVGPGPESSPVL-VRTDEDVPSGPPRKVEVEPLNSTAVHVYW 729
Query: 1075 ---VPPAQPNGLVFYYVSLILQQTPRHVRPPLVT----------------YERSIYFDNL 1115
VP Q + Y V+ + + P++ YE +I L
Sbjct: 730 KLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQWRPEESEDYETTI--SGL 787
Query: 1116 EKYTDYILKITPSTEKGFSDTYTAQLYIKTEEDVPETSPIINTFKNLSSTSVLLSWDPPV 1175
T Y + + T KG ++ T + +I+T + + LL W PP
Sbjct: 788 TPETTYSVTVAAYTTKGDGARSKPKIVTTTGAVPGRPTMMIST---TAMNTALLQWHPPK 844
Query: 1176 KPNGAIISYDLTLQGPNE----NYSFITSDNYIILEELSPFTLYSFFAAARTRKGLGPSS 1231
+ G ++ Y L +E F D + + L T Y F AA+ R GLG
Sbjct: 845 ELPGELLGYRLQYCRADEARPNTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEF 904
Query: 1232 ILFFYTDESVPLAPPQNLTLINCTSDFVWLKWSPSPLPGGIVKVYSFKIHEHETDTIYYK 1291
T E +P PQNL + T+ L W P L ++ S+ + + ++
Sbjct: 905 EKEIRTPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRDINSQQEL 964
Query: 1292 NISGFKTEAKLVGLEPVSTYSIRVSAFTKVGNGNQFSNVVKFTTQESVPDVVQNMQCMAT 1351
T L GL+P +TY I+V A+T G+G S ++ T +N + A
Sbjct: 965 QNITTDTRFTLTGLKPDTTYDIKVRAWTSKGSG-PLSPSIQSRTMPVEQVFAKNFRVAAA 1023
Query: 1352 SWQSVLVKWDPPKKANGIITQYMVTVERNSTKVSPQDHMYTFIKLLANTSYVFKVRASTS 1411
SVL+ W+ P + + + S +V L NT Y F + S
Sbjct: 1024 MKTSVLLSWEVPDSYKSAVP-FKILYNGQSVEVDGHSMRKLIADLQPNTEYSFVLMNRGS 1082
Query: 1412 AGEGDESTCHVSTLPETVPSVP 1433
+ G + + T P+ +P P
Sbjct: 1083 SAGGLQHLVSIRTAPDLLPHKP 1104
Score = 193 bits (491), Expect = 1e-48
Identities = 197/772 (25%), Positives = 333/772 (43%), Gaps = 86/772 (11%)
Query: 493 NSHPDKNFPARNRAEDQTSPVVTTRNQYITDIAAEQLSYVIRRLVPFTEHMISVSAFTIM 552
NS P + + RA P Q + +A + Y I L PF+E+ V A +
Sbjct: 343 NSEPVTYYGIQYRAAGTEGPF-----QEVDGVATTR--YSIGGLSPFSEYAFRVLAVNSI 395
Query: 553 GEGPPT-VLSVRTRQQVPSSI-KIINYKNISSSSILLYWDPPEYPNGKITHYTIYAMELD 610
G GPP+ + RT +Q PSS + + + +S+S++L+ W+PPE PNG + Y +Y D
Sbjct: 396 GRGPPSEAVRARTGEQAPSSPPRRVQARMLSASTMLVQWEPPEEPNGLVRGYRVYYTP-D 454
Query: 611 TNR---AFQITTIDNSFLIT--GLKKYTKYKMRVAASTHVGESSLSEENDIFVRTSEDEP 665
+ R A+ D L T L Y +RV A T VG+ S I V+T + P
Sbjct: 455 SRRPPNAWHKHNTDAGLLTTVGSLLPGITYSLRVLAFTAVGDGPPSP--TIQVKTQQGVP 512
Query: 666 ESSPQDVEVIDVTADEIRLKWSPPEKPNGIIIAYEVLYKNIDTLYMKNTSTTD----IIL 721
+ P D + + I+L W P P II YE++Y + ++ T D L
Sbjct: 513 -AQPADFQAEVESDTRIQLSWLLP--PQERIIMYELVYWAAEDEDQQHKVTFDPTSSYTL 569
Query: 722 RNLRPHTLYNISVRSYTRFGHGNQVSSLLSVRTSETVPDSAPENITYKNISSGEIELSFL 781
+L+P TLY + + + G G + + RT+++ P + P+ + ++ S + +S++
Sbjct: 570 EDLKPDTLYRFQLAARSDMGVG-VFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVRVSWV 628
Query: 782 PP--SSPNGIIQKYTIYLKRSNGNEERT-----INTTSLTQNIKVLKKYTQYIIEVSAST 834
PP S NG+I +Y++ + +G + I+ + ++ L+K+T+Y + V A T
Sbjct: 629 PPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISREHSSWDLVGLEKWTEYRVWVRAHT 688
Query: 835 LKGEGVRSAPISILTEEDAPDSPPQDFSVKQLSGVTVKLSWQPPL--------------- 879
G G S+P+ + T+ED P PP+ V+ L+ V + W+ P+
Sbjct: 689 DVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTY 748
Query: 880 ------EPNGIILYYTVYV----WNRSSLKTINVTETSLELSDLDYNVEYSAYVTASTRF 929
EP G+ + V + W + T +S L YS V A T
Sbjct: 749 VRLENGEPRGLPIIQDVMLAEAQWRPEESEDYETT-----ISGLTPETTYSVTVAAYTTK 803
Query: 930 GDGKTRSNIISFQTPEGAPSDPPKDVYYANLSSSSIILFWTPPSKPNGIIQYYSVYYRNT 989
GDG RS T P P + + + ++ +L W PP + G + Y + Y
Sbjct: 804 GDG-ARSKPKIVTTTGAVPGRP--TMMISTTAMNTALLQWHPPKELPGELLGYRLQYCRA 860
Query: 990 SGTFMQNFTLHEVTNDFDNMTVSTIIDKLTIFSYYTFWLTASTSVGNGNKSSDIIEVYTD 1049
+ D + TV+ + T Y F L A G G + E+ T
Sbjct: 861 DEARPNTI---DFGKDDQHFTVTGLHKGTT----YIFRLAAKNRAGLGEEFEK--EIRTP 911
Query: 1050 QDIPEGFVGNLTYESISSTAINVSWVPP--AQPNGLVFYYVSLILQQTPRHVRPPLVTYE 1107
+D+P GF NL ++++ ++W PP A+ NG + Y +++ + +T +
Sbjct: 912 EDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISY-TVVFRDINSQQELQNITTD 970
Query: 1108 RSIYFDNLEKYTDYILKITPSTEKGFSDTYTAQLYIKTEEDVPETSPIINTFKNLSS--T 1165
L+ T Y +K+ T KG S + + +T +P F+ ++ T
Sbjct: 971 TRFTLTGLKPDTTYDIKVRAWTSKG-SGPLSPSIQSRT---MPVEQVFAKNFRVAAAMKT 1026
Query: 1166 SVLLSWDPPVKPNGAIISYDLTLQGPNENYSFITSDNYIILEELSPFTLYSF 1217
SVLLSW+ P A + + + G + + ++ +L P T YSF
Sbjct: 1027 SVLLSWEVPDSYKSA-VPFKILYNGQSVEVDGHSMRK--LIADLQPNTEYSF 1075
Score = 183 bits (465), Expect = 1e-45
Identities = 101/245 (41%), Positives = 137/245 (55%), Gaps = 6/245 (2%)
Query: 2022 ADLPWNRAKNRFPNIKPYNNNRVKLIADASVPGSDYINASYISGYLCPNEFIATQGPLPG 2081
A+LP N+ KNR NI PY RV L V GSDYINAS++ GY +IATQGPL
Sbjct: 1659 ANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAE 1718
Query: 2082 TVGDFWRMVWETRAKTLVMLTQCFEKGRIRCHQYWPEDNKPVTVFGDIVITKLMEDVQID 2141
+ DFWRM+WE + +VMLT+ E GR +CHQYWP + + V+ + E
Sbjct: 1719 STEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAERS--ARYQYFVVDPMAEYNMPQ 1776
Query: 2142 WTIRDLKI--ERHGDCMTVRQCNFTAWPEHGVPENSAPLIHFVKLVRASRAH--DTTPMI 2197
+ +R+ K+ R G T+RQ FT WPE GVP+ I F+ V ++ P+
Sbjct: 1777 YILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPIT 1836
Query: 2198 VHCSAGVGRTGVFIALDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCIL 2257
VHCSAGVGRTGVFI L + + + VD++ V LR++R MVQ QY ++ L
Sbjct: 1837 VHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAAL 1896
Query: 2258 DLLSN 2262
+ L +
Sbjct: 1897 EYLGS 1901
Score = 174 bits (442), Expect = 7e-43
Identities = 192/680 (28%), Positives = 284/680 (41%), Gaps = 65/680 (9%)
Query: 820 LKKYTQYIIEVSASTLKGEGVRSAPISILTEEDAPDSPPQDFSVKQLSGVTVKLSWQPPL 879
L +++Y V A G G S + T E AP SPP+ + LS T+ + W+PP
Sbjct: 379 LSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSPPRRVQARMLSASTMLVQWEPPE 438
Query: 880 EPNGIILYYTVYVWNRSSLKTINV-----TETSL--ELSDLDYNVEYSAYVTASTRFGDG 932
EPNG++ Y VY + S + N T+ L + L + YS V A T GDG
Sbjct: 439 EPNGLVRGYRVY-YTPDSRRPPNAWHKHNTDAGLLTTVGSLLPGITYSLRVLAFTAVGDG 497
Query: 933 KTRSNIISFQTPEGAPSDPPKDVYYANLSSSSIILFWTPPSKPNGIIQYYSVYYRNTSGT 992
S I +T +G P+ P D S + I L W P + II Y VY+
Sbjct: 498 PP-SPTIQVKTQQGVPAQ-PADFQAEVESDTRIQLSWLLPPQER-IIMYELVYW-----A 549
Query: 993 FMQNFTLHEVTNDFDNMTVSTIIDKLTIFSYYTFWLTASTSVGNGNKSSDIIEVYTDQDI 1052
H+VT D T S ++ L + Y F L A + +G G + IE T Q
Sbjct: 550 AEDEDQQHKVTFD---PTSSYTLEDLKPDTLYRFQLAARSDMGVG-VFTPTIEARTAQST 605
Query: 1053 PEGFVGNLTYESISSTAINVSWVPPA--QPNGLV----FYYVSLILQQTPRHVRPPLVTY 1106
P + S+ ST + VSWVPP NG++ Y ++ + RHV +
Sbjct: 606 PSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISRE 665
Query: 1107 ERSIYFDNLEKYTDYILKITPSTEKGFSDTYTAQLYIKTEEDVPETSPIINTFKNLSSTS 1166
S LEK+T+Y + + T+ G ++ + ++T+EDVP P + L+ST+
Sbjct: 666 HSSWDLVGLEKWTEYRVWVRAHTDVG-PGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTA 724
Query: 1167 VLLSWDPPV--KPNGAIISYDLTL----QGPNENYSFI--------------TSDNYIIL 1206
V + W PV K +G I Y +T G I + D +
Sbjct: 725 VHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQWRPEESEDYETTI 784
Query: 1207 EELSPFTLYSFFAAARTRKGLGP-SSILFFYTDESVPLAPPQNLTLINCTSDFVWLKW-S 1264
L+P T YS AA T KG G S T +VP P + + + L+W
Sbjct: 785 SGLTPETTYSVTVAAYTTKGDGARSKPKIVTTTGAVPGRP--TMMISTTAMNTALLQWHP 842
Query: 1265 PSPLPGGIV--KVYSFKIHEHETDTIYYKNISGFKTEAKLVGLEPVSTYSIRVSAFTKVG 1322
P LPG ++ ++ + E +TI + T + GL +TY R++A + G
Sbjct: 843 PKELPGELLGYRLQYCRADEARPNTIDFGKDDQHFT---VTGLHKGTTYIFRLAAKNRAG 899
Query: 1323 NGNQFSNVVKFTTQESVPD-VVQNMQCMATSWQSVLVKWDPPKKA--NGIITQYMVTVER 1379
G +F ++ T E +P QN+ + + + WDPP A NG I Y V
Sbjct: 900 LGEEFEKEIR--TPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRD 957
Query: 1380 NSTKVSPQ----DHMYTFIKLLANTSYVFKVRASTSAGEGDESTCHVSTLPETVPSVPTN 1435
+++ Q D +T L +T+Y KVRA TS G G S S N
Sbjct: 958 INSQQELQNITTDTRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVEQVFAKN 1017
Query: 1436 IAFSDVQSTSATLTWIRPDT 1455
+ TS L+W PD+
Sbjct: 1018 FRVAAAMKTSVLLSWEVPDS 1037
Score = 173 bits (438), Expect = 2e-42
Identities = 204/799 (25%), Positives = 334/799 (41%), Gaps = 85/799 (10%)
Query: 857 PPQDFSVKQLSGVTVKLSWQPP-LEPNGIILYYTVYVWNRSS----LKTINVTETSLELS 911
PP D V + + +V L+W EP + YY + + + V T +
Sbjct: 321 PPIDLVVTETTATSVTLTWDSGNSEP---VTYYGIQYRAAGTEGPFQEVDGVATTRYSIG 377
Query: 912 DLDYNVEYSAYVTASTRFGDGKTRSNIISFQTPEGAPSDPPKDVYYANLSSSSIILFWTP 971
L EY+ V A G G S + +T E APS PP+ V LS+S++++ W P
Sbjct: 378 GLSPFSEYAFRVLAVNSIGRGPP-SEAVRARTGEQAPSSPPRRVQARMLSASTMLVQWEP 436
Query: 972 PSKPNGIIQYYSVYYRNTSGTFMQNFTLHEVTNDFDNMTVSTIIDKLTIFSYYTFWLTAS 1031
P +PNG+++ Y VYY S + H T+ TV +++ +T Y+ + A
Sbjct: 437 PEEPNGLVRGYRVYYTPDSRRPPNAWHKHN-TDAGLLTTVGSLLPGIT----YSLRVLAF 491
Query: 1032 TSVGNGNKSSDIIEVYTDQDIPEGFVGNLTYESISSTAINVSWVPPAQPNGLVFYYVSLI 1091
T+VG+G S I+V T Q +P + E S T I +SW+ P Q +++ V
Sbjct: 492 TAVGDG-PPSPTIQVKTQQGVPAQ-PADFQAEVESDTRIQLSWLLPPQERIIMYELVYWA 549
Query: 1092 LQQTPRHVRPPLVTYE--RSIYFDNLEKYTDYILKITPSTEKGFSDTYTAQLYIKTEEDV 1149
+ + + VT++ S ++L+ T Y ++ ++ G +T + +T +
Sbjct: 550 AEDEDQQHK---VTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVG-VFTPTIEARTAQST 605
Query: 1150 PETSPIINTFKNLSSTSVLLSWDPPVKP--NGAIISYDLTLQ-------GPNENYSFITS 1200
P P ++ ST+V +SW PP NG I Y + + G +
Sbjct: 606 PSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISRE 665
Query: 1201 DNYIILEELSPFTLYSFFAAARTRKGLGP-SSILFFYTDESVPLAPPQNLTLINCTSDFV 1259
+ L L +T Y + A T G GP SS + TDE VP PP+ + + S V
Sbjct: 666 HSSWDLVGLEKWTEYRVWVRAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTAV 725
Query: 1260 WLKWSPSPLPG---GIVKVYSFK--------------IHEHETDTIYYKNISGFKTEAKL 1302
+ W P+P G ++ Y I + ++ E +
Sbjct: 726 HVYWK-LPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQWRPEESEDYETTI 784
Query: 1303 VGLEPVSTYSIRVSAFTKVGNGNQFSNVVKFTTQESVPDVVQNMQCMATSWQSVLVKWDP 1362
GL P +TYS+ V+A+T G+G + + TT +VP M T+ + L++W P
Sbjct: 785 SGLTPETTYSVTVAAYTTKGDGARSKPKI-VTTTGAVPGR-PTMMISTTAMNTALLQWHP 842
Query: 1363 PKKANGIITQYMVTVER------NSTKVSPQDHMYTFIKLLANTSYVFKVRASTSAGEGD 1416
PK+ G + Y + R N+ D +T L T+Y+F++ A AG G+
Sbjct: 843 PKELPGELLGYRLQYCRADEARPNTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGLGE 902
Query: 1417 ESTCHVSTLPETVPS-VPTNIAFSDVQSTSATLTWIRPDTILGYFQNYKITTQLRAQKCK 1475
E + T PE +PS P N+ + + +++ L W P + T R
Sbjct: 903 EFEKEIRT-PEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFR----- 956
Query: 1476 EWESEECVEYQKIQYLYEAHLTEETVYGLKKFRWYRFQVAASTNAGYGNASNWISTKTLP 1535
+ Q++Q + T T+ GLK Y +V A T+ G G S I ++T+P
Sbjct: 957 -----DINSQQELQNITTD--TRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMP 1009
Query: 1536 GPPDGPPENVHVVATSPFSISISWSEPAVITG--PTCYLIDVKSVDNDEFNISFIKSNEE 1593
+N V A S+ +SW P P L + +SV+ D ++ +
Sbjct: 1010 -VEQVFAKNFRVAAAMKTSVLLSWEVPDSYKSAVPFKILYNGQSVEVDGHSMRKL----- 1063
Query: 1594 NKTIEIKDLEIFTRYSVVI 1612
I DL+ T YS V+
Sbjct: 1064 -----IADLQPNTEYSFVL 1077
Score = 137 bits (346), Expect = 9e-32
Identities = 214/896 (23%), Positives = 344/896 (38%), Gaps = 118/896 (13%)
Query: 152 ESAPGKVVNLTVEAYNASAVKLIWYLPRQPNGKITSFKISVKHARSGIVVKDVSIRVEDI 211
E PG VNLT A A + W + + K + VV+ + I
Sbjct: 242 EVMPGGSVNLTCVAVGAPMPYVKWMMGAEELTKEDEMPVGRNVLELSNVVRSANYTCVAI 301
Query: 212 LTGKLPECNENSESFLWSTASPSPTLGRVTPPSRTTHSSSTLTQNEISSVWKEPISFV-- 269
+ + E + A P P + V + TT +S TLT + +S EP+++
Sbjct: 302 SSLGMIEATAQ----VTVKALPKPPIDLVV--TETTATSVTLTWDSGNS---EPVTYYGI 352
Query: 270 -----------------------VTHLRPYTTYLFEVSAATTEAGYIDSTIVR--TPESV 304
+ L P++ Y F V A + S VR T E
Sbjct: 353 QYRAAGTEGPFQEVDGVATTRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQA 412
Query: 305 PEGPPQNCVTGNITGKSFSILWDPPTIVTGKF-SYRVELYGPSGR------ILDNSTKDL 357
P PP+ ++ + + W+PP G YRV Y P R N+ L
Sbjct: 413 PSSPPRRVQARMLSASTMLVQWEPPEEPNGLVRGYRV-YYTPDSRRPPNAWHKHNTDAGL 471
Query: 358 KFAFTNLTPFTMYDVYIAAETSAGTGPKS-NISVFTPPDVPGAVFDLQLAEVES-TQVRI 415
+L P Y + + A T+ G GP S I V T VP D Q AEVES T++++
Sbjct: 472 LTTVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPADFQ-AEVESDTRIQL 530
Query: 416 TWKKPRQPNGIINQYRVKVLVPETGIILENTLLTGNNEYINDPMAPEI------------ 463
+W P P I Y + E + Y + + P+
Sbjct: 531 SWLLP--PQERIIMYELVYWAAEDEDQQHKVTFDPTSSYTLEDLKPDTLYRFQLAARSDM 588
Query: 464 -VNIVEPMVGLYEGSAEMSSDLHSL------ATFIYNSHPDKNFPARNRAEDQTSPVVTT 516
V + P + + S+ + +T + S +RN Q S
Sbjct: 589 GVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEA 648
Query: 517 -----RNQYITD-IAAEQLSYVIRRLVPFTEHMISVSAFTIMGEGP-PTVLSVRTRQQVP 569
R +++ D I+ E S+ + L +TE+ + V A T +G GP + + VRT + VP
Sbjct: 649 VDGEDRGRHVVDGISREHSSWDLVGLEKWTEYRVWVRAHTDVGPGPESSPVLVRTDEDVP 708
Query: 570 SS-IKIINYKNISSSSILLYW--DPPEYPNGKITHYTIYAMELDTNRAFQITTIDNSFL- 625
S + + + ++S+++ +YW P +G+I Y + + L+ + I + L
Sbjct: 709 SGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLA 768
Query: 626 ---------------ITGLKKYTKYKMRVAASTHVGESSLSEENDIFVRTSEDEPESSPQ 670
I+GL T Y + VAA T G+ + S+ V T+ P +
Sbjct: 769 EAQWRPEESEDYETTISGLTPETTYSVTVAAYTTKGDGARSKPK--IVTTTGAVP---GR 823
Query: 671 DVEVIDVTA-DEIRLKWSPPEKPNGIIIAYEVLYKNIDTLYMKNT-----STTDIILRNL 724
+I TA + L+W PP++ G ++ Y + Y D NT + L
Sbjct: 824 PTMMISTTAMNTALLQWHPPKELPGELLGYRLQYCRADEA-RPNTIDFGKDDQHFTVTGL 882
Query: 725 RPHTLYNISVRSYTRFGHGNQVSSLLSVRTSETVPDSAPENITYKNISSGEIELSFLPP- 783
T Y + + R G G + +RT E +P P+N+ +++ EL++ PP
Sbjct: 883 HKGTTYIFRLAAKNRAGLGEEFEK--EIRTPEDLPSGFPQNLHVTGLTTSTTELAWDPPV 940
Query: 784 -SSPNGIIQKYTIYLKRSNGNEERTINTTSLTQNIKVLKKYTQYIIEVSASTLKGEGVRS 842
+ NG I YT+ + N +E TT + LK T Y I+V A T KG G S
Sbjct: 941 LAERNGRIISYTVVFRDINSQQELQNITTDTRFTLTGLKPDTTYDIKVRAWTSKGSGPLS 1000
Query: 843 APISILTEEDAPDSPPQDFSVKQLSGVTVKLSWQPPLEPNGIILYYTVYVWNRSSLKTIN 902
I T ++F V +V LSW+ P + + +Y N S++
Sbjct: 1001 PSIQSRT-MPVEQVFAKNFRVAAAMKTSVLLSWEVPDSYKSAVPFKILY--NGQSVEVDG 1057
Query: 903 VTETSLELSDLDYNVEYSAYVTASTRFGDGKTRSNIISFQT-PEGAPSDP-PKDVY 956
+ L ++DL N EYS R +++S +T P+ P P P Y
Sbjct: 1058 HSMRKL-IADLQPNTEYS--FVLMNRGSSAGGLQHLVSIRTAPDLLPHKPLPASAY 1110
Score = 126 bits (316), Expect = 3e-28
Identities = 126/531 (23%), Positives = 216/531 (40%), Gaps = 54/531 (10%)
Query: 1245 PPQNLTLINCTSDFVWLKW-SPSPLPGGIVKVYSFKIHEHETDTIYYKNISGFKTEAKLV 1303
PP +L + T+ V L W S + P V Y + T+ + + T +
Sbjct: 321 PPIDLVVTETTATSVTLTWDSGNSEP---VTYYGIQYRAAGTEGPFQEVDGVATTRYSIG 377
Query: 1304 GLEPVSTYSIRVSAFTKVGNGNQFSNVVKFTTQESVPDVVQNMQCMATSWQSVLVKWDPP 1363
GL P S Y+ RV A +G G V T +++ + +Q S ++LV+W+PP
Sbjct: 378 GLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSPPRRVQARMLSASTMLVQWEPP 437
Query: 1364 KKANGIITQYMVTVERNSTKVSPQDHMY--------TFIKLLANTSYVFKVRASTSAGEG 1415
++ NG++ Y V +S + H + T LL +Y +V A T+ G+G
Sbjct: 438 EEPNGLVRGYRVYYTPDSRRPPNAWHKHNTDAGLLTTVGSLLPGITYSLRVLAFTAVGDG 497
Query: 1416 DESTCHVSTLPETVPSVPTNIAFSDVQSTSATLTWIRP--DTILGYFQNYKITTQLRAQK 1473
S + VP+ P + T L+W+ P + I+ Y Y
Sbjct: 498 PPSPTIQVKTQQGVPAQPADFQAEVESDTRIQLSWLLPPQERIIMYELVY---------- 547
Query: 1474 CKEWESEECVEYQKIQYLYEAHLTEETVYGLKKFRWYRFQVAASTNAGYGNASNWISTKT 1533
W +E+ + K+ + + T+ LK YRFQ+AA ++ G G + I +T
Sbjct: 548 ---WAAEDEDQQHKVTF---DPTSSYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEART 601
Query: 1534 LPGPPDGPPENVHVVATSPFSISISWSEPAVITGP---TCYLIDVKSVDNDEFNISFIKS 1590
P PP+ V V+ ++ +SW P + T Y + ++VD ++ +
Sbjct: 602 AQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVDG 661
Query: 1591 -NEENKTIEIKDLEIFTRYSVVITAFTGNISAAYVEGKSSAEMIVTTLESAPKDPPNNMT 1649
+ E+ + ++ LE +T Y V + A T G S+ ++V T E P PP +
Sbjct: 662 ISREHSSWDLVGLEKWTEYRVWVRAHTD-----VGPGPESSPVLVRTDEDVPSGPPRKVE 716
Query: 1650 FQKIPDEVTKFQLTFLPPSQPNGNIQVYQALVYREDDPTAVQIHNLSIIQ---------- 1699
+ + PS+ +G I+ YQ R ++ + L IIQ
Sbjct: 717 VEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLENG---EPRGLPIIQDVMLAEAQWR 773
Query: 1700 -KTNTFVIAMLEGLKGGHTYNISVYAVNSAGAGPK-VPMRITMDIKAPARP 1748
+ + + GL TY+++V A + G G + P +T P RP
Sbjct: 774 PEESEDYETTISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTTGAVPGRP 824
Score = 113 bits (282), Expect = 2e-24
Identities = 122/468 (26%), Positives = 182/468 (38%), Gaps = 69/468 (14%)
Query: 21 VSNVVPGTRYDITI---SSISTTYTSPVTRIVTTNVTKPGPPVFLAGERVGSAGILLSWN 77
+ ++ P T Y + S + +P T T PP + +GS + +SW
Sbjct: 569 LEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVRVSWV 628
Query: 78 TPP--NPNGRIISYIVKYKEVCPWMQTVYTQVRSKPDSLEVLLTNLNPGTTYEIKVAAEN 135
PP + NG I Y V Y+ V + + + L L T Y + V A
Sbjct: 629 PPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISREHSSWDLVGLEKWTEYRVWVRAHT 688
Query: 136 SAGIGVFSDPFLFQTAESAP-GKVVNLTVEAYNASAVKLIWYLP--RQPNGKITSFKISV 192
G G S P L +T E P G + VE N++AV + W LP + +G+I ++++
Sbjct: 689 DVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTY 748
Query: 193 KHARSGI-----VVKDVSIR-----------VEDILTGKLPECNENSESFLWST----AS 232
+G +++DV + E ++G PE + ++T A
Sbjct: 749 VRLENGEPRGLPIIQDVMLAEAQWRPEESEDYETTISGLTPETTYSVTVAAYTTKGDGAR 808
Query: 233 PSPTLGRVTP--PSRTTHSSSTLTQNEISSVWKEPIS----------------------- 267
P + T P R T ST N W P
Sbjct: 809 SKPKIVTTTGAVPGRPTMMISTTAMNTALLQWHPPKELPGELLGYRLQYCRADEARPNTI 868
Query: 268 --------FVVTHLRPYTTYLFEVSAATTEAGYIDS--TIVRTPESVPEGPPQNCVTGNI 317
F VT L TTY+F + AA AG + +RTPE +P G PQN +
Sbjct: 869 DFGKDDQHFTVTGLHKGTTYIFRL-AAKNRAGLGEEFEKEIRTPEDLPSGFPQNLHVTGL 927
Query: 318 TGKSFSILWDPPTIVTGK---FSYRVELYG-PSGRILDNSTKDLKFAFTNLTPFTMYDVY 373
T + + WDPP + SY V S + L N T D +F T L P T YD+
Sbjct: 928 TTSTTELAWDPPVLAERNGRIISYTVVFRDINSQQELQNITTDTRFTLTGLKPDTTYDIK 987
Query: 374 IAAETSAGTGPKS-NISVFTPPDVPGAVFDLQLAEVESTQVRITWKKP 420
+ A TS G+GP S +I T P + ++A T V ++W+ P
Sbjct: 988 VRAWTSKGSGPLSPSIQSRTMPVEQVFAKNFRVAAAMKTSVLLSWEVP 1035
Score = 112 bits (280), Expect = 4e-24
Identities = 135/573 (23%), Positives = 231/573 (40%), Gaps = 63/573 (10%)
Query: 267 SFVVTHLRPYTTYLFEVSAATTEA-GYIDSTI-VRTPESVPEGPPQNCVTGNITGKSFSI 324
S+ + L+P T Y F+++A + G TI RT +S P PPQ + ++ + +
Sbjct: 566 SYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVRV 625
Query: 325 LWDPPTI-----VTGKFSYRVELYGPSGR---ILDN-STKDLKFAFTNLTPFTMYDVYIA 375
W PP V ++S E R ++D S + + L +T Y V++
Sbjct: 626 SWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISREHSSWDLVGLEKWTEYRVWVR 685
Query: 376 AETSAGTGPKSN-ISVFTPPDVP-GAVFDLQLAEVESTQVRITWK--KPRQPNGIINQYR 431
A T G GP+S+ + V T DVP G +++ + ST V + WK P + +G I Y+
Sbjct: 686 AHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQ 745
Query: 432 VKVLVPETG-----IILENTLL---------TGNNEYINDPMAPEIVNIV---------- 467
V + E G I+++ +L + + E + PE V
Sbjct: 746 VTYVRLENGEPRGLPIIQDVMLAEAQWRPEESEDYETTISGLTPETTYSVTVAAYTTKGD 805
Query: 468 ----EPMV----GLYEGSAEMSSDLHSLATFIYNSHPDKNFPARNRAEDQTSPVVTTRNQ 519
+P + G G M ++ T + HP K P
Sbjct: 806 GARSKPKIVTTTGAVPGRPTMMISTTAMNTALLQWHPPKELPGELLGYRLQYCRADEARP 865
Query: 520 YITDIAAEQLSYVIRRLVPFTEHMISVSAFTIMGEGPPTVLSVRTRQQVPSSI-KIINYK 578
D + + + L T ++ ++A G G +RT + +PS + ++
Sbjct: 866 NTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEFEKEIRTPEDLPSGFPQNLHVT 925
Query: 579 NISSSSILLYWDPPEYP--NGKITHYTIYAMELDTNRAFQITTIDNSFLITGLKKYTKYK 636
+++S+ L WDPP NG+I YT+ ++++ + Q T D F +TGLK T Y
Sbjct: 926 GLTTSTTELAWDPPVLAERNGRIISYTVVFRDINSQQELQNITTDTRFTLTGLKPDTTYD 985
Query: 637 MRVAASTHVGESSLSEENDIFVRTSEDEPESSPQDVEVIDVTADEIRLKWSPPEKPNGII 696
++V A T G LS I RT E + ++ V + L W P+
Sbjct: 986 IKVRAWTSKGSGPLSP--SIQSRTMPVE-QVFAKNFRVAAAMKTSVLLSWEVPDSYKS-A 1041
Query: 697 IAYEVLYKNIDTLYMKNTSTTDIILRNLRPHTLYNISVRSYTRFGHGNQVSSLLSVRTSE 756
+ +++LY N ++ + S +I +L+P+T Y S+ G+ L + +
Sbjct: 1042 VPFKILY-NGQSVEVDGHSMRKLI-ADLQPNTEY-----SFVLMNRGSSAGGLQHLVSIR 1094
Query: 757 TVPDSAPENITYKN--ISSGEIELSFLPPSSPN 787
T PD P + I G +LS P+
Sbjct: 1095 TAPDLLPHKPLPASAYIEDGRFDLSMPHVQDPS 1127
Score = 110 bits (275), Expect = 2e-23
Identities = 161/669 (24%), Positives = 265/669 (39%), Gaps = 94/669 (14%)
Query: 1115 LEKYTDYILKITPSTEKGFSDTYTAQLYIKTEEDVPETSPIINTFKNLSSTSVLLSWDPP 1174
L +++Y ++ G A + +T E P + P + LS++++L+ W+PP
Sbjct: 379 LSPFSEYAFRVLAVNSIGRGPPSEA-VRARTGEQAPSSPPRRVQARMLSASTMLVQWEPP 437
Query: 1175 VKPNGAIISYDL-----TLQGPNENYSFITSDNYII-LEELSPFTLYSFFAAARTRKGLG 1228
+PNG + Y + + + PN + T + + L P YS A T G G
Sbjct: 438 EEPNGLVRGYRVYYTPDSRRPPNAWHKHNTDAGLLTTVGSLLPGITYSLRVLAFTAVGDG 497
Query: 1229 PSS-ILFFYTDESVPLAPPQNLTLINCTSDFVWLKWSPSPLPGGIVK--VYSFKIHEHET 1285
P S + T + VP P + + + L W P I+ VY E +
Sbjct: 498 PPSPTIQVKTQQGVPAQPADFQAEVESDTR-IQLSWLLPPQERIIMYELVYWAAEDEDQQ 556
Query: 1286 DTIYYKNISGFKTEAKLVGLEPVSTYSIRVSAFTKVGNGNQFSNVVKFTTQESVPDVV-Q 1344
+ + S + E L+P + Y +++A + +G G F+ ++ T +S P Q
Sbjct: 557 HKVTFDPTSSYTLE----DLKPDTLYRFQLAARSDMGVG-VFTPTIEARTAQSTPSAPPQ 611
Query: 1345 NMQCMATSWQSVLVKWDPPK--KANGIITQYMVTVERNSTK---------VSPQDHMYTF 1393
+ C++ +V V W PP NG+ITQY V E + +S + +
Sbjct: 612 KVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISREHSSWDL 671
Query: 1394 IKLLANTSYVFKVRASTSAGEGDESTCHVSTLPETVPS-VPTNIAFSDVQSTSATLTWIR 1452
+ L T Y VRA T G G ES+ + E VPS P + + ST+ + W
Sbjct: 672 VGLEKWTEYRVWVRAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKL 731
Query: 1453 P--DTILGYFQNYKITTQLRAQKCK---------------EWESEECVEYQKIQYLYEAH 1495
P G + Y++T +R + + +W EE +Y
Sbjct: 732 PVPSKQHGQIRGYQVT-YVRLENGEPRGLPIIQDVMLAEAQWRPEESEDY---------- 780
Query: 1496 LTEETVYGLKKFRWYRFQVAASTNAGYGNASN---WISTKTLPGPPDGPPENVHVVATSP 1552
E T+ GL Y VAA T G G S +T +PG P + + T+
Sbjct: 781 --ETTISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTTGAVPGRP-----TMMISTTAM 833
Query: 1553 FSISISWSEPAVITGPTCYLIDVKSVDNDEFNISFIKSNEEN-KTIEI-KDLEIFTRYSV 1610
+ + W P + G + + + +++E TI+ KD + FT +
Sbjct: 834 NTALLQWHPPKELPGELL-----------GYRLQYCRADEARPNTIDFGKDDQHFTVTGL 882
Query: 1611 VI-TAFTGNISAAYVEGKSSA-EMIVTTLESAPKDPPNNMTFQKIPDEVTKFQLTFLPP- 1667
T + ++A G E + T E P P N+ + T +L + PP
Sbjct: 883 HKGTTYIFRLAAKNRAGLGEEFEKEIRTPEDLPSGFPQNLHVTGLTTSTT--ELAWDPPV 940
Query: 1668 -SQPNGNIQVYQALVYREDDPTAVQIHNLSIIQKTNTFVIAMLEGLKGGHTYNISVYAVN 1726
++ NG I Y +V+R+ I++ +Q T L GLK TY+I V A
Sbjct: 941 LAERNGRIISY-TVVFRD-------INSQQELQNITTDTRFTLTGLKPDTTYDIKVRAWT 992
Query: 1727 SAGAGPKVP 1735
S G+GP P
Sbjct: 993 SKGSGPLSP 1001
Score = 79.7 bits (195), Expect = 3e-14
Identities = 155/753 (20%), Positives = 274/753 (36%), Gaps = 124/753 (16%)
Query: 13 GTSETQVDVSNVVPGTRYD---ITISSISTTYTSPVTRIVTTNVTKPGPPVFLAGERVGS 69
G + T+ + + P + Y + ++SI S R T PP + + +
Sbjct: 368 GVATTRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSPPRRVQARMLSA 427
Query: 70 AGILLSWNTPPNPNGRIISYIVKYKEVCPWMQTVYTQVRSKPDSLEVLLTNLNPGTTYEI 129
+ +L+ W P PNG + Y V Y + + + L + +L PG TY +
Sbjct: 428 STMLVQWEPPEEPNGLVRGYRVYYTPDSRRPPNAWHK-HNTDAGLLTTVGSLLPGITYSL 486
Query: 130 KVAAENSAGIGVFSDPFLFQTAESAPGKVVNLTVEAYNASAVKLIWYLPRQPNGKITSFK 189
+V A + G G S +T + P + + E + + ++L W LP P +I ++
Sbjct: 487 RVLAFTAVGDGPPSPTIQVKTQQGVPAQPADFQAEVESDTRIQLSWLLP--PQERIIMYE 544
Query: 190 ISVKHARSGIVVKDV------SIRVEDILTGKLPECNENSESFL--------------WS 229
+ A V S +ED+ L + S + S
Sbjct: 545 LVYWAAEDEDQQHKVTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQS 604
Query: 230 TASPSP------TLGRVT-----PPSRTTHSSSTLTQNEIS---------------SVWK 263
T S P ++G T P + +TQ ++ + +
Sbjct: 605 TPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISR 664
Query: 264 EPISFVVTHLRPYTTYLFEVSAATTEAGYIDST--IVRTPESVPEGPPQNCVTGNITGKS 321
E S+ + L +T Y V A T +S+ +VRT E VP GPP+ + +
Sbjct: 665 EHSSWDLVGLEKWTEYRVWVRAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTA 724
Query: 322 FSILWDPPT-------IVTGKFSY-RVELYGPSGRIL------------DNSTKDLKFAF 361
+ W P I + +Y R+E P G + ++D +
Sbjct: 725 VHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQWRPEESEDYETTI 784
Query: 362 TNLTPFTMYDVYIAAETSAGTGPKSNISVFTPPD-VPGAVFDLQLAEVESTQVRITWKKP 420
+ LTP T Y V +AA T+ G G +S + T VPG + ++ + W P
Sbjct: 785 SGLTPETTYSVTVAAYTTKGDGARSKPKIVTTTGAVPGRP-TMMISTTAMNTALLQWHPP 843
Query: 421 RQPNGIINQYRVKVLVPETGIILENTLLTGNNE-------------YINDPMAPEIVNIV 467
++ G + YR++ + NT+ G ++ YI A +
Sbjct: 844 KELPGELLGYRLQYCRADEA--RPNTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGLG 901
Query: 468 EPMVGLYEGSAEMSSDLHSLATFIYNSHPDKNFPARNRAEDQTSPVVTTRNQYI------ 521
E +E DL S F N H PV+ RN I
Sbjct: 902 EE----FEKEIRTPEDLPS--GFPQNLHV-TGLTTSTTELAWDPPVLAERNGRIISYTVV 954
Query: 522 -TDIAAEQ--------LSYVIRRLVPFTEHMISVSAFTIMGEGPPTVLSVRTRQQVPSSI 572
DI ++Q + + L P T + I V A+T G GP + S+++R +
Sbjct: 955 FRDINSQQELQNITTDTRFTLTGLKPDTTYDIKVRAWTSKGSGPLSP-SIQSRTMPVEQV 1013
Query: 573 KIINYKNISS--SSILLYWDPPEYPNGKITHYTIYAMELDTNRAFQITTIDNSFLITGLK 630
N++ ++ +S+LL W+ P+ + +Y ++ ++ LI L+
Sbjct: 1014 FAKNFRVAAAMKTSVLLSWEVPDSYKSAVPFKILY-----NGQSVEVDGHSMRKLIADLQ 1068
Query: 631 KYTKYKMRVAASTHVGESSLSEENDIFVRTSED 663
T+Y + G S+ ++ + +RT+ D
Sbjct: 1069 PNTEYSF---VLMNRGSSAGGLQHLVSIRTAPD 1098
Score = 76.3 bits (186), Expect = 3e-13
Identities = 73/332 (21%), Positives = 136/332 (40%), Gaps = 41/332 (12%)
Query: 14 TSETQVDVSNVVPGTRYDITISSISTTYTSPVTR--IVTTNVTKPGPPVFLAGERVGSAG 71
+ + + +S + P T Y +T+++ +T ++ IVTT PG P + +
Sbjct: 777 SEDYETTISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTTGAVPGRPTMMISTTAMNTA 836
Query: 72 ILLSWNTPPNPNGRIISYIVKYKEVCPWMQTVYTQVRSKPDSLEVLLTNLNPGTTYEIKV 131
LL W+ P G ++ Y ++Y C + + D +T L+ GTTY ++
Sbjct: 837 -LLQWHPPKELPGELLGYRLQY---CRADEARPNTIDFGKDDQHFTVTGLHKGTTYIFRL 892
Query: 132 AAENSAGIGVFSDPFLFQTAESAPGKVVNLTVEAYNASAVKLIWYLP--RQPNGKITSFK 189
AA+N AG+G + + + G NL V S +L W P + NG+I S+
Sbjct: 893 AAKNRAGLGEEFEKEIRTPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYT 952
Query: 190 ISVKHARSGIVVKDVSIRVEDILTGKLPECNENSESFLWSTASP---SPTLGRVTPPSRT 246
+ + S +++++ LTG P+ + + W++ SP++ T P
Sbjct: 953 VVFRDINSQQELQNITTDTRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVEQ 1012
Query: 247 THS----------SSTLTQNEISSVWKEPISF------------------VVTHLRPYTT 278
+ +S L E+ +K + F ++ L+P T
Sbjct: 1013 VFAKNFRVAAAMKTSVLLSWEVPDSYKSAVPFKILYNGQSVEVDGHSMRKLIADLQPNTE 1072
Query: 279 YLFEVSAATTEAGYIDSTI-VRT-PESVPEGP 308
Y F + + AG + + +RT P+ +P P
Sbjct: 1073 YSFVLMNRGSSAGGLQHLVSIRTAPDLLPHKP 1104
>gi|109633039 protein tyrosine phosphatase, receptor type, F isoform 2
precursor [Homo sapiens]
Length = 1898
Score = 254 bits (650), Expect = 5e-67
Identities = 156/442 (35%), Positives = 241/442 (54%), Gaps = 17/442 (3%)
Query: 1861 NGPLKPKKQY----LFKFRATNIMGQFTDSDYSDPVKTLGEGLSERTVEIILSVTLCILS 1916
N PL P Y L + ++ S YSD + ++ +L VT +L+
Sbjct: 1202 NRPLSPDLSYQCFVLASLKEPMDQKRYASSPYSDEIVVQVTPAQQQEEPEMLWVTGPVLA 1261
Query: 1917 IILLGTAIFAFARIRQKQKEGGTYSPQDAEIIDTKLKLDQLITVADLELKDERLTRLLSY 1976
+IL+ + A ++K+ T+SP + LK D L+ + ++ RL
Sbjct: 1262 VILIILIVIAILLFKRKR----THSPSSKDEQSIGLK-DSLLAHSSDPVEMRRLNYQTPG 1316
Query: 1977 RKSIKPISKKSFLQHVEELCTNNNLKFQEEFSELPKFLQDLSSTDADLPWNRAKNRFPNI 2036
+ PI ++E L N+ LKF +E+ + Q + +++L N+ KNR+ N+
Sbjct: 1317 MRDHPPIPITDLADNIERLKANDGLKFSQEYESIDPG-QQFTWENSNLEVNKPKNRYANV 1375
Query: 2037 KPYNNNRVKLIADASVPGSDYINASYISGYLCPNEFIATQGPLPGTVGDFWRMVWETRAK 2096
Y+++RV L + VPGSDYINA+YI GY N +IATQGPLP T+GDFWRMVWE R
Sbjct: 1376 IAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTA 1435
Query: 2097 TLVMLTQCFEKGRIRCHQYWPEDNKPVTVFGDIVITKLMEDVQI-DWTIRDLKIERHG-- 2153
T+VM+T+ EK R++C QYWP + G I +T L++ V++ +T+R + + G
Sbjct: 1436 TVVMMTRLEEKSRVKCDQYWPA--RGTETCGLIQVT-LLDTVELATYTVRTFALHKSGSS 1492
Query: 2154 DCMTVRQCNFTAWPEHGVPENSAPLIHFVKLVRASRAHDTTPMIVHCSAGVGRTGVFIAL 2213
+ +RQ F AWP+HGVPE P++ F++ V+A D PM+VHCSAGVGRTG FI +
Sbjct: 1493 EKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVI 1552
Query: 2214 DHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLLSNKGSNQPICFVN 2273
D + + + VDIYG V +RS+R MVQ QY+F+H+ +L+ + + P +
Sbjct: 1553 DAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPARNL- 1611
Query: 2274 YSALQKMDSLDAMEGDVELEWE 2295
Y+ +QK+ + E +E E
Sbjct: 1612 YAHIQKLGQVPPGESVTAMELE 1633
Score = 212 bits (540), Expect = 3e-54
Identities = 200/791 (25%), Positives = 328/791 (41%), Gaps = 43/791 (5%)
Query: 669 PQDVEVIDVTADEIRLKW-SPPEKPNGIIIAYEVLYKNIDT----LYMKNTSTTDIILRN 723
P D+ V + TA + L W S +P + Y + Y+ T + +TT +
Sbjct: 322 PIDLVVTETTATSVTLTWDSGNSEP---VTYYGIQYRAAGTEGPFQEVDGVATTRYSIGG 378
Query: 724 LRPHTLYNISVRSYTRFGHGNQVSSLLSVRTSETVPDSAPENITYKNISSGEIELSFLPP 783
L P + Y V + G G S + RT E P S P + + +S+ + + + PP
Sbjct: 379 LSPFSEYAFRVLAVNSIGRGPP-SEAVRARTGEQAPSSPPRRVQARMLSASTMLVQWEPP 437
Query: 784 SSPNGIIQKYTIYL---KRSNGNEERTINTTS-LTQNIKVLKKYTQYIIEVSASTLKGEG 839
PNG+++ Y +Y R N NT + L + L Y + V A T G+G
Sbjct: 438 EEPNGLVRGYRVYYTPDSRRPPNAWHKHNTDAGLLTTVGSLLPGITYSLRVLAFTAVGDG 497
Query: 840 VRSAPISILTEEDAPDSPPQDFSVKQLSGVTVKLSWQPPLEPNGIILYYTVYVWNRSSLK 899
S I + T++ P + P DF + S ++LSW P + II+Y VY +
Sbjct: 498 PPSPTIQVKTQQGVP-AQPADFQAEVESDTRIQLSWLLPPQER-IIMYELVYWAAEDEDQ 555
Query: 900 TINVT---ETSLELSDLDYNVEYSAYVTASTRFGDGKTRSNIISFQTPEGAPSDPPKDVY 956
VT +S L DL + Y + A + G G + I +T + PS PP+ V
Sbjct: 556 QHKVTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVG-VFTPTIEARTAQSTPSAPPQKVM 614
Query: 957 YANLSSSSIILFWTPP--SKPNGIIQYYSVYYRNTSGTFMQNFTLHEVTNDFDNMTVSTI 1014
++ S+++ + W PP NG+I YSV Y G + ++ + + +
Sbjct: 615 CVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISREHSSWDLVG- 673
Query: 1015 IDKLTIFSYYTFWLTASTSVGNGNKSSDIIEVYTDQDIPEGFVGNLTYESISSTAINVSW 1074
L ++ Y W+ A T VG G +SS ++ V TD+D+P G + E ++STA++V W
Sbjct: 674 ---LEKWTEYRVWVRAHTDVGPGPESSPVL-VRTDEDVPSGPPRKVEVEPLNSTAVHVYW 729
Query: 1075 ---VPPAQPNGLVFYYVSLILQQT--PRH---VRPPLVTYERSIYFDNLEKYTDYILKIT 1126
VP Q + Y V+ + + PR ++ ++ + L T Y + +
Sbjct: 730 KLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQETTISGLTPETTYSVTVA 789
Query: 1127 PSTEKGFSDTYTAQLYIKTEEDVPETSPIINTFKNLSSTSVLLSWDPPVKPNGAIISYDL 1186
T KG ++ T + +I+T + + LL W PP + G ++ Y L
Sbjct: 790 AYTTKGDGARSKPKIVTTTGAVPGRPTMMIST---TAMNTALLQWHPPKELPGELLGYRL 846
Query: 1187 TLQGPNE----NYSFITSDNYIILEELSPFTLYSFFAAARTRKGLGPSSILFFYTDESVP 1242
+E F D + + L T Y F AA+ R GLG T E +P
Sbjct: 847 QYCRADEARPNTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEFEKEIRTPEDLP 906
Query: 1243 LAPPQNLTLINCTSDFVWLKWSPSPLPGGIVKVYSFKIHEHETDTIYYKNISGFKTEAKL 1302
PQNL + T+ L W P L ++ S+ + + ++ T L
Sbjct: 907 SGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRDINSQQELQNITTDTRFTL 966
Query: 1303 VGLEPVSTYSIRVSAFTKVGNGNQFSNVVKFTTQESVPDVVQNMQCMATSWQSVLVKWDP 1362
GL+P +TY I+V A+T G+G S ++ T +N + A SVL+ W+
Sbjct: 967 TGLKPDTTYDIKVRAWTSKGSG-PLSPSIQSRTMPVEQVFAKNFRVAAAMKTSVLLSWEV 1025
Query: 1363 PKKANGIITQYMVTVERNSTKVSPQDHMYTFIKLLANTSYVFKVRASTSAGEGDESTCHV 1422
P + + + S +V L NT Y F + S+ G + +
Sbjct: 1026 PDSYKSAVP-FKILYNGQSVEVDGHSMRKLIADLQPNTEYSFVLMNRGSSAGGLQHLVSI 1084
Query: 1423 STLPETVPSVP 1433
T P+ +P P
Sbjct: 1085 RTAPDLLPHKP 1095
Score = 211 bits (538), Expect = 5e-54
Identities = 206/806 (25%), Positives = 340/806 (42%), Gaps = 68/806 (8%)
Query: 581 SSSSILLYWDPPEYPNGKITHYTIYAMELDTNRAFQIT--TIDNSFLITGLKKYTKYKMR 638
+++S+ L WD + +T+Y I T FQ + I GL +++Y R
Sbjct: 331 TATSVTLTWDSGN--SEPVTYYGIQYRAAGTEGPFQEVDGVATTRYSIGGLSPFSEYAFR 388
Query: 639 VAASTHVGESSLSEENDIFVRTSEDEPESSPQDVEVIDVTADEIRLKWSPPEKPNGIIIA 698
V A +G SE + RT E P S P+ V+ ++A + ++W PPE+PNG++
Sbjct: 389 VLAVNSIGRGPPSEA--VRARTGEQAPSSPPRRVQARMLSASTMLVQWEPPEEPNGLVRG 446
Query: 699 YEVLY----KNIDTLYMKNTSTTDII--LRNLRPHTLYNISVRSYTRFGHGNQVSSLLSV 752
Y V Y + + K+ + ++ + +L P Y++ V ++T G G S + V
Sbjct: 447 YRVYYTPDSRRPPNAWHKHNTDAGLLTTVGSLLPGITYSLRVLAFTAVGDGPP-SPTIQV 505
Query: 753 RTSETVPDSAPENITYKNISSGEIELSFLPPSSPNGIIQKYTIYLKRSNGNEERTINTTS 812
+T + VP + P + + S I+LS+L P I+ + + + + +
Sbjct: 506 KTQQGVP-AQPADFQAEVESDTRIQLSWLLPPQERIIMYELVYWAAEDEDQQHKVTFDPT 564
Query: 813 LTQNIKVLKKYTQYIIEVSASTLKGEGVRSAPISILTEEDAPDSPPQDFSVKQLSGVTVK 872
+ ++ LK T Y +++A + G GV + I T + P +PPQ + TV+
Sbjct: 565 SSYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVR 624
Query: 873 LSWQPPL--EPNGIILYYTVYV-------WNRSSLKTINVTETSLELSDLDYNVEYSAYV 923
+SW PP NG+I Y+V R + I+ +S +L L+ EY +V
Sbjct: 625 VSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISREHSSWDLVGLEKWTEYRVWV 684
Query: 924 TASTRFGDGKTRSNIISFQTPEGAPSDPPKDVYYANLSSSSIILFW--TPPSKPNGIIQY 981
A T G G S ++ +T E PS PP+ V L+S+++ ++W PSK +G I+
Sbjct: 685 RAHTDVGPGPESSPVL-VRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRG 743
Query: 982 YSV-YYRNTSG-----TFMQNFTLHEVTNDFDNMTVSTIIDKLTIFSYYTFWLTASTSVG 1035
Y V Y R +G +Q+ L E T I LT + Y+ + A T+ G
Sbjct: 744 YQVTYVRLENGEPRGLPIIQDVMLAEAQ--------ETTISGLTPETTYSVTVAAYTTKG 795
Query: 1036 NGNKSSDIIEVYTDQDIPEGFVGNLTYESISSTAIN---VSWVPPAQ-PNGLVFYYVSLI 1091
+G +S I T G V IS+TA+N + W PP + P L+ Y +
Sbjct: 796 DGARSKPKIVTTT------GAVPGRPTMMISTTAMNTALLQWHPPKELPGELLGYRLQYC 849
Query: 1092 LQQTPRHVRPPLVTYERSIYFDNLEKYTDYILKITPSTEKGFSDTYTAQLYIKTEEDVPE 1151
R ++ L K T YI ++ G + + + I+T ED+P
Sbjct: 850 RADEARPNTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEFEKE--IRTPEDLPS 907
Query: 1152 TSPIINTFKNLSSTSVLLSWDPPV--KPNGAIISYDLTLQGPNENYSF--ITSDNYIILE 1207
P L++++ L+WDPPV + NG IISY + + N IT+D L
Sbjct: 908 GFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRDINSQQELQNITTDTRFTLT 967
Query: 1208 ELSPFTLYSFFAAARTRKGLGPSSILFFYTDESVPLAPPQNLTLINCTSDFVWLKWSPSP 1267
L P T Y A T KG GP S V +N + V L W
Sbjct: 968 GLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVEQVFAKNFRVAAAMKTSVLLSWE--- 1024
Query: 1268 LPGGIVKVYSFKIHEHETDTIYYKNISGFKTEAKLVGLEPVSTYSIRVSAFTKVGNGNQF 1327
+P FKI + + G + L+P + YS F + G+
Sbjct: 1025 VPDSYKSAVPFKILYNGQSV----EVDGHSMRKLIADLQPNTEYS-----FVLMNRGSSA 1075
Query: 1328 SNVVKFTTQESVPDVVQNMQCMATSW 1353
+ + + PD++ + A+++
Sbjct: 1076 GGLQHLVSIRTAPDLLPHKPLPASAY 1101
Score = 194 bits (494), Expect = 6e-49
Identities = 198/758 (26%), Positives = 337/758 (44%), Gaps = 67/758 (8%)
Query: 493 NSHPDKNFPARNRAEDQTSPVVTTRNQYITDIAAEQLSYVIRRLVPFTEHMISVSAFTIM 552
NS P + + RA P Q + +A + Y I L PF+E+ V A +
Sbjct: 343 NSEPVTYYGIQYRAAGTEGPF-----QEVDGVATTR--YSIGGLSPFSEYAFRVLAVNSI 395
Query: 553 GEGPPT-VLSVRTRQQVPSSI-KIINYKNISSSSILLYWDPPEYPNGKITHYTIYAMELD 610
G GPP+ + RT +Q PSS + + + +S+S++L+ W+PPE PNG + Y +Y D
Sbjct: 396 GRGPPSEAVRARTGEQAPSSPPRRVQARMLSASTMLVQWEPPEEPNGLVRGYRVYYTP-D 454
Query: 611 TNR---AFQITTIDNSFLIT--GLKKYTKYKMRVAASTHVGESSLSEENDIFVRTSEDEP 665
+ R A+ D L T L Y +RV A T VG+ S I V+T + P
Sbjct: 455 SRRPPNAWHKHNTDAGLLTTVGSLLPGITYSLRVLAFTAVGDGPPSP--TIQVKTQQGVP 512
Query: 666 ESSPQDVEVIDVTADEIRLKWSPPEKPNGIIIAYEVLYKNIDTLYMKNTSTTD----IIL 721
+ P D + + I+L W P P II YE++Y + ++ T D L
Sbjct: 513 -AQPADFQAEVESDTRIQLSWLLP--PQERIIMYELVYWAAEDEDQQHKVTFDPTSSYTL 569
Query: 722 RNLRPHTLYNISVRSYTRFGHGNQVSSLLSVRTSETVPDSAPENITYKNISSGEIELSFL 781
+L+P TLY + + + G G + + RT+++ P + P+ + ++ S + +S++
Sbjct: 570 EDLKPDTLYRFQLAARSDMGVG-VFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVRVSWV 628
Query: 782 PP--SSPNGIIQKYTIYLKRSNGNEERT-----INTTSLTQNIKVLKKYTQYIIEVSAST 834
PP S NG+I +Y++ + +G + I+ + ++ L+K+T+Y + V A T
Sbjct: 629 PPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISREHSSWDLVGLEKWTEYRVWVRAHT 688
Query: 835 LKGEGVRSAPISILTEEDAPDSPPQDFSVKQLSGVTVKLSWQPPL--EPNGIILYYTV-Y 891
G G S+P+ + T+ED P PP+ V+ L+ V + W+ P+ + +G I Y V Y
Sbjct: 689 DVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTY 748
Query: 892 VWNRSS-------LKTINVTET-SLELSDLDYNVEYSAYVTASTRFGDGKTRSNIISFQT 943
V + ++ + + E +S L YS V A T GDG RS T
Sbjct: 749 VRLENGEPRGLPIIQDVMLAEAQETTISGLTPETTYSVTVAAYTTKGDG-ARSKPKIVTT 807
Query: 944 PEGAPSDPPKDVYYANLSSSSIILFWTPPSKPNGIIQYYSVYYRNTSGTFMQNFTLHEVT 1003
P P + + + ++ +L W PP + G + Y + Y +
Sbjct: 808 TGAVPGRP--TMMISTTAMNTALLQWHPPKELPGELLGYRLQYCRADEARPNTI---DFG 862
Query: 1004 NDFDNMTVSTIIDKLTIFSYYTFWLTASTSVGNGNKSSDIIEVYTDQDIPEGFVGNLTYE 1063
D + TV+ + T Y F L A G G + E+ T +D+P GF NL
Sbjct: 863 KDDQHFTVTGLHKGTT----YIFRLAAKNRAGLGEEFEK--EIRTPEDLPSGFPQNLHVT 916
Query: 1064 SISSTAINVSWVPP--AQPNGLVFYYVSLILQQTPRHVRPPLVTYERSIYFDNLEKYTDY 1121
++++ ++W PP A+ NG + Y +++ + +T + L+ T Y
Sbjct: 917 GLTTSTTELAWDPPVLAERNGRIISY-TVVFRDINSQQELQNITTDTRFTLTGLKPDTTY 975
Query: 1122 ILKITPSTEKGFSDTYTAQLYIKTEEDVPETSPIINTFKNLSS--TSVLLSWDPPVKPNG 1179
+K+ T KG S + + +T +P F+ ++ TSVLLSW+ P
Sbjct: 976 DIKVRAWTSKG-SGPLSPSIQSRT---MPVEQVFAKNFRVAAAMKTSVLLSWEVPDSYKS 1031
Query: 1180 AIISYDLTLQGPNENYSFITSDNYIILEELSPFTLYSF 1217
A + + + G + + ++ +L P T YSF
Sbjct: 1032 A-VPFKILYNGQSVEVDGHSMRK--LIADLQPNTEYSF 1066
Score = 183 bits (465), Expect = 1e-45
Identities = 101/245 (41%), Positives = 137/245 (55%), Gaps = 6/245 (2%)
Query: 2022 ADLPWNRAKNRFPNIKPYNNNRVKLIADASVPGSDYINASYISGYLCPNEFIATQGPLPG 2081
A+LP N+ KNR NI PY RV L V GSDYINAS++ GY +IATQGPL
Sbjct: 1650 ANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAE 1709
Query: 2082 TVGDFWRMVWETRAKTLVMLTQCFEKGRIRCHQYWPEDNKPVTVFGDIVITKLMEDVQID 2141
+ DFWRM+WE + +VMLT+ E GR +CHQYWP + + V+ + E
Sbjct: 1710 STEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAERS--ARYQYFVVDPMAEYNMPQ 1767
Query: 2142 WTIRDLKI--ERHGDCMTVRQCNFTAWPEHGVPENSAPLIHFVKLVRASRAH--DTTPMI 2197
+ +R+ K+ R G T+RQ FT WPE GVP+ I F+ V ++ P+
Sbjct: 1768 YILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPIT 1827
Query: 2198 VHCSAGVGRTGVFIALDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCIL 2257
VHCSAGVGRTGVFI L + + + VD++ V LR++R MVQ QY ++ L
Sbjct: 1828 VHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAAL 1887
Query: 2258 DLLSN 2262
+ L +
Sbjct: 1888 EYLGS 1892
Score = 176 bits (447), Expect = 2e-43
Identities = 205/790 (25%), Positives = 333/790 (42%), Gaps = 76/790 (9%)
Query: 857 PPQDFSVKQLSGVTVKLSWQPP-LEPNGIILYYTVYVWNRSS----LKTINVTETSLELS 911
PP D V + + +V L+W EP + YY + + + V T +
Sbjct: 321 PPIDLVVTETTATSVTLTWDSGNSEP---VTYYGIQYRAAGTEGPFQEVDGVATTRYSIG 377
Query: 912 DLDYNVEYSAYVTASTRFGDGKTRSNIISFQTPEGAPSDPPKDVYYANLSSSSIILFWTP 971
L EY+ V A G G S + +T E APS PP+ V LS+S++++ W P
Sbjct: 378 GLSPFSEYAFRVLAVNSIGRGPP-SEAVRARTGEQAPSSPPRRVQARMLSASTMLVQWEP 436
Query: 972 PSKPNGIIQYYSVYYRNTSGTFMQNFTLHEVTNDFDNMTVSTIIDKLTIFSYYTFWLTAS 1031
P +PNG+++ Y VYY S + H T+ TV +++ +T Y+ + A
Sbjct: 437 PEEPNGLVRGYRVYYTPDSRRPPNAWHKHN-TDAGLLTTVGSLLPGIT----YSLRVLAF 491
Query: 1032 TSVGNGNKSSDIIEVYTDQDIPEGFVGNLTYESISSTAINVSWVPPAQPNGLVFYYVSLI 1091
T+VG+G S I+V T Q +P + E S T I +SW+ P Q +++ V
Sbjct: 492 TAVGDG-PPSPTIQVKTQQGVPAQ-PADFQAEVESDTRIQLSWLLPPQERIIMYELVYWA 549
Query: 1092 LQQTPRHVRPPLVTYE--RSIYFDNLEKYTDYILKITPSTEKGFSDTYTAQLYIKTEEDV 1149
+ + + VT++ S ++L+ T Y ++ ++ G +T + +T +
Sbjct: 550 AEDEDQQHK---VTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVG-VFTPTIEARTAQST 605
Query: 1150 PETSPIINTFKNLSSTSVLLSWDPPVKP--NGAIISYDLTLQ-------GPNENYSFITS 1200
P P ++ ST+V +SW PP NG I Y + + G +
Sbjct: 606 PSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISRE 665
Query: 1201 DNYIILEELSPFTLYSFFAAARTRKGLGP-SSILFFYTDESVPLAPPQNLTLINCTSDFV 1259
+ L L +T Y + A T G GP SS + TDE VP PP+ + + S V
Sbjct: 666 HSSWDLVGLEKWTEYRVWVRAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTAV 725
Query: 1260 WLKWSPSPLPG---GIVKVYSFKIHEHETDT-----IYYKNISGFKTEAKLVGLEPVSTY 1311
+ W P+P G ++ Y E I + E + GL P +TY
Sbjct: 726 HVYWK-LPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQETTISGLTPETTY 784
Query: 1312 SIRVSAFTKVGNGNQFSNVVKFTTQESVPDVVQNMQCMATSWQSVLVKWDPPKKANGIIT 1371
S+ V+A+T G+G + + TT +VP M T+ + L++W PPK+ G +
Sbjct: 785 SVTVAAYTTKGDGARSKPKI-VTTTGAVPGR-PTMMISTTAMNTALLQWHPPKELPGELL 842
Query: 1372 QYMVTVER------NSTKVSPQDHMYTFIKLLANTSYVFKVRASTSAGEGDESTCHVSTL 1425
Y + R N+ D +T L T+Y+F++ A AG G+E + T
Sbjct: 843 GYRLQYCRADEARPNTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEFEKEIRT- 901
Query: 1426 PETVPS-VPTNIAFSDVQSTSATLTWIRPDTILGYFQNYKITTQLRAQKCKEWESEECVE 1484
PE +PS P N+ + + +++ L W P + T R +
Sbjct: 902 PEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFR----------DINS 951
Query: 1485 YQKIQYLYEAHLTEETVYGLKKFRWYRFQVAASTNAGYGNASNWISTKTLPGPPDGPPEN 1544
Q++Q + T T+ GLK Y +V A T+ G G S I ++T+P +N
Sbjct: 952 QQELQNITTD--TRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMP-VEQVFAKN 1008
Query: 1545 VHVVATSPFSISISWSEPAVITG--PTCYLIDVKSVDNDEFNISFIKSNEENKTIEIKDL 1602
V A S+ +SW P P L + +SV+ D ++ + I DL
Sbjct: 1009 FRVAAAMKTSVLLSWEVPDSYKSAVPFKILYNGQSVEVDGHSMRKL----------IADL 1058
Query: 1603 EIFTRYSVVI 1612
+ T YS V+
Sbjct: 1059 QPNTEYSFVL 1068
Score = 176 bits (446), Expect = 2e-43
Identities = 192/671 (28%), Positives = 285/671 (42%), Gaps = 56/671 (8%)
Query: 820 LKKYTQYIIEVSASTLKGEGVRSAPISILTEEDAPDSPPQDFSVKQLSGVTVKLSWQPPL 879
L +++Y V A G G S + T E AP SPP+ + LS T+ + W+PP
Sbjct: 379 LSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSPPRRVQARMLSASTMLVQWEPPE 438
Query: 880 EPNGIILYYTVYVWNRSSLKTINV-----TETSL--ELSDLDYNVEYSAYVTASTRFGDG 932
EPNG++ Y VY + S + N T+ L + L + YS V A T GDG
Sbjct: 439 EPNGLVRGYRVY-YTPDSRRPPNAWHKHNTDAGLLTTVGSLLPGITYSLRVLAFTAVGDG 497
Query: 933 KTRSNIISFQTPEGAPSDPPKDVYYANLSSSSIILFWTPPSKPNGIIQYYSVYYRNTSGT 992
S I +T +G P+ P D S + I L W P + II Y VY+
Sbjct: 498 PP-SPTIQVKTQQGVPAQ-PADFQAEVESDTRIQLSWLLPPQER-IIMYELVYW-----A 549
Query: 993 FMQNFTLHEVTNDFDNMTVSTIIDKLTIFSYYTFWLTASTSVGNGNKSSDIIEVYTDQDI 1052
H+VT D T S ++ L + Y F L A + +G G + IE T Q
Sbjct: 550 AEDEDQQHKVTFD---PTSSYTLEDLKPDTLYRFQLAARSDMGVG-VFTPTIEARTAQST 605
Query: 1053 PEGFVGNLTYESISSTAINVSWVPPA--QPNGLV----FYYVSLILQQTPRHVRPPLVTY 1106
P + S+ ST + VSWVPP NG++ Y ++ + RHV +
Sbjct: 606 PSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISRE 665
Query: 1107 ERSIYFDNLEKYTDYILKITPSTEKGFSDTYTAQLYIKTEEDVPETSPIINTFKNLSSTS 1166
S LEK+T+Y + + T+ G ++ + ++T+EDVP P + L+ST+
Sbjct: 666 HSSWDLVGLEKWTEYRVWVRAHTDVG-PGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTA 724
Query: 1167 VLLSWDPPV--KPNGAIISYDLT---LQGPNENYSFITSDNYI------ILEELSPFTLY 1215
V + W PV K +G I Y +T L+ I D + + L+P T Y
Sbjct: 725 VHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQETTISGLTPETTY 784
Query: 1216 SFFAAARTRKGLGP-SSILFFYTDESVPLAPPQNLTLINCTSDFVWLKW-SPSPLPGGIV 1273
S AA T KG G S T +VP P + + + L+W P LPG ++
Sbjct: 785 SVTVAAYTTKGDGARSKPKIVTTTGAVPGRP--TMMISTTAMNTALLQWHPPKELPGELL 842
Query: 1274 --KVYSFKIHEHETDTIYYKNISGFKTEAKLVGLEPVSTYSIRVSAFTKVGNGNQFSNVV 1331
++ + E +TI + T + GL +TY R++A + G G +F +
Sbjct: 843 GYRLQYCRADEARPNTIDFGKDDQHFT---VTGLHKGTTYIFRLAAKNRAGLGEEFEKEI 899
Query: 1332 KFTTQESVPD-VVQNMQCMATSWQSVLVKWDPPKKA--NGIITQYMVTVERNSTKVSPQ- 1387
+ T E +P QN+ + + + WDPP A NG I Y V +++ Q
Sbjct: 900 R--TPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRDINSQQELQN 957
Query: 1388 ---DHMYTFIKLLANTSYVFKVRASTSAGEGDESTCHVSTLPETVPSVPTNIAFSDVQST 1444
D +T L +T+Y KVRA TS G G S S N + T
Sbjct: 958 ITTDTRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVEQVFAKNFRVAAAMKT 1017
Query: 1445 SATLTWIRPDT 1455
S L+W PD+
Sbjct: 1018 SVLLSWEVPDS 1028
Score = 141 bits (355), Expect = 8e-33
Identities = 214/887 (24%), Positives = 344/887 (38%), Gaps = 109/887 (12%)
Query: 152 ESAPGKVVNLTVEAYNASAVKLIWYLPRQPNGKITSFKISVKHARSGIVVKDVSIRVEDI 211
E PG VNLT A A + W + + K + VV+ + I
Sbjct: 242 EVMPGGSVNLTCVAVGAPMPYVKWMMGAEELTKEDEMPVGRNVLELSNVVRSANYTCVAI 301
Query: 212 LTGKLPECNENSESFLWSTASPSPTLGRVTPPSRTTHSSSTLTQNEISSVWKEPISFV-- 269
+ + E + A P P + V + TT +S TLT + +S EP+++
Sbjct: 302 SSLGMIEATAQ----VTVKALPKPPIDLVV--TETTATSVTLTWDSGNS---EPVTYYGI 352
Query: 270 -----------------------VTHLRPYTTYLFEVSAATTEAGYIDSTIVR--TPESV 304
+ L P++ Y F V A + S VR T E
Sbjct: 353 QYRAAGTEGPFQEVDGVATTRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQA 412
Query: 305 PEGPPQNCVTGNITGKSFSILWDPPTIVTGKF-SYRVELYGPSGR------ILDNSTKDL 357
P PP+ ++ + + W+PP G YRV Y P R N+ L
Sbjct: 413 PSSPPRRVQARMLSASTMLVQWEPPEEPNGLVRGYRV-YYTPDSRRPPNAWHKHNTDAGL 471
Query: 358 KFAFTNLTPFTMYDVYIAAETSAGTGPKS-NISVFTPPDVPGAVFDLQLAEVES-TQVRI 415
+L P Y + + A T+ G GP S I V T VP D Q AEVES T++++
Sbjct: 472 LTTVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPADFQ-AEVESDTRIQL 530
Query: 416 TWKKPRQPNGIINQYRVKVLVPETGIILENTLLTGNNEYINDPMAPEI------------ 463
+W P P I Y + E + Y + + P+
Sbjct: 531 SWLLP--PQERIIMYELVYWAAEDEDQQHKVTFDPTSSYTLEDLKPDTLYRFQLAARSDM 588
Query: 464 -VNIVEPMVGLYEGSAEMSSDLHSL------ATFIYNSHPDKNFPARNRAEDQTSPVVTT 516
V + P + + S+ + +T + S +RN Q S
Sbjct: 589 GVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEA 648
Query: 517 -----RNQYITD-IAAEQLSYVIRRLVPFTEHMISVSAFTIMGEGP-PTVLSVRTRQQVP 569
R +++ D I+ E S+ + L +TE+ + V A T +G GP + + VRT + VP
Sbjct: 649 VDGEDRGRHVVDGISREHSSWDLVGLEKWTEYRVWVRAHTDVGPGPESSPVLVRTDEDVP 708
Query: 570 SS-IKIINYKNISSSSILLYW--DPPEYPNGKITHYTIYAMELDTNRAFQITTIDNSFL- 625
S + + + ++S+++ +YW P +G+I Y + + L+ + I + L
Sbjct: 709 SGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLA 768
Query: 626 ------ITGLKKYTKYKMRVAASTHVGESSLSEENDIFVRTSEDEPESSPQDVEVIDVTA 679
I+GL T Y + VAA T G+ + S+ V T+ P + +I TA
Sbjct: 769 EAQETTISGLTPETTYSVTVAAYTTKGDGARSKPK--IVTTTGAVP---GRPTMMISTTA 823
Query: 680 -DEIRLKWSPPEKPNGIIIAYEVLYKNIDTLYMKNT-----STTDIILRNLRPHTLYNIS 733
+ L+W PP++ G ++ Y + Y D NT + L T Y
Sbjct: 824 MNTALLQWHPPKELPGELLGYRLQYCRADEA-RPNTIDFGKDDQHFTVTGLHKGTTYIFR 882
Query: 734 VRSYTRFGHGNQVSSLLSVRTSETVPDSAPENITYKNISSGEIELSFLPP--SSPNGIIQ 791
+ + R G G + +RT E +P P+N+ +++ EL++ PP + NG I
Sbjct: 883 LAAKNRAGLGEEFEK--EIRTPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRII 940
Query: 792 KYTIYLKRSNGNEERTINTTSLTQNIKVLKKYTQYIIEVSASTLKGEGVRSAPISILTEE 851
YT+ + N +E TT + LK T Y I+V A T KG G S I T
Sbjct: 941 SYTVVFRDINSQQELQNITTDTRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRT-M 999
Query: 852 DAPDSPPQDFSVKQLSGVTVKLSWQPPLEPNGIILYYTVYVWNRSSLKTINVTETSLELS 911
++F V +V LSW+ P + + +Y N S++ + L ++
Sbjct: 1000 PVEQVFAKNFRVAAAMKTSVLLSWEVPDSYKSAVPFKILY--NGQSVEVDGHSMRKL-IA 1056
Query: 912 DLDYNVEYSAYVTASTRFGDGKTRSNIISFQT-PEGAPSDP-PKDVY 956
DL N EYS R +++S +T P+ P P P Y
Sbjct: 1057 DLQPNTEYS--FVLMNRGSSAGGLQHLVSIRTAPDLLPHKPLPASAY 1101
Score = 129 bits (325), Expect = 3e-29
Identities = 125/522 (23%), Positives = 215/522 (41%), Gaps = 45/522 (8%)
Query: 1245 PPQNLTLINCTSDFVWLKW-SPSPLPGGIVKVYSFKIHEHETDTIYYKNISGFKTEAKLV 1303
PP +L + T+ V L W S + P V Y + T+ + + T +
Sbjct: 321 PPIDLVVTETTATSVTLTWDSGNSEP---VTYYGIQYRAAGTEGPFQEVDGVATTRYSIG 377
Query: 1304 GLEPVSTYSIRVSAFTKVGNGNQFSNVVKFTTQESVPDVVQNMQCMATSWQSVLVKWDPP 1363
GL P S Y+ RV A +G G V T +++ + +Q S ++LV+W+PP
Sbjct: 378 GLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSPPRRVQARMLSASTMLVQWEPP 437
Query: 1364 KKANGIITQYMVTVERNSTKVSPQDHMY--------TFIKLLANTSYVFKVRASTSAGEG 1415
++ NG++ Y V +S + H + T LL +Y +V A T+ G+G
Sbjct: 438 EEPNGLVRGYRVYYTPDSRRPPNAWHKHNTDAGLLTTVGSLLPGITYSLRVLAFTAVGDG 497
Query: 1416 DESTCHVSTLPETVPSVPTNIAFSDVQSTSATLTWIRP--DTILGYFQNYKITTQLRAQK 1473
S + VP+ P + T L+W+ P + I+ Y Y
Sbjct: 498 PPSPTIQVKTQQGVPAQPADFQAEVESDTRIQLSWLLPPQERIIMYELVY---------- 547
Query: 1474 CKEWESEECVEYQKIQYLYEAHLTEETVYGLKKFRWYRFQVAASTNAGYGNASNWISTKT 1533
W +E+ + K+ + + T+ LK YRFQ+AA ++ G G + I +T
Sbjct: 548 ---WAAEDEDQQHKVTF---DPTSSYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEART 601
Query: 1534 LPGPPDGPPENVHVVATSPFSISISWSEPAVITGP---TCYLIDVKSVDNDEFNISFIKS 1590
P PP+ V V+ ++ +SW P + T Y + ++VD ++ +
Sbjct: 602 AQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVDG 661
Query: 1591 -NEENKTIEIKDLEIFTRYSVVITAFTGNISAAYVEGKSSAEMIVTTLESAPKDPPNNMT 1649
+ E+ + ++ LE +T Y V + A T G S+ ++V T E P PP +
Sbjct: 662 ISREHSSWDLVGLEKWTEYRVWVRAHTD-----VGPGPESSPVLVRTDEDVPSGPPRKVE 716
Query: 1650 FQKIPDEVTKFQLTFLPPSQPNGNIQVYQALVYR--EDDPTAVQIHNLSIIQKTNTFVIA 1707
+ + PS+ +G I+ YQ R +P + I ++ + I+
Sbjct: 717 VEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQETTIS 776
Query: 1708 MLEGLKGGHTYNISVYAVNSAGAGPK-VPMRITMDIKAPARP 1748
GL TY+++V A + G G + P +T P RP
Sbjct: 777 ---GLTPETTYSVTVAAYTTKGDGARSKPKIVTTTGAVPGRP 815
Score = 119 bits (298), Expect = 3e-26
Identities = 135/564 (23%), Positives = 229/564 (40%), Gaps = 54/564 (9%)
Query: 267 SFVVTHLRPYTTYLFEVSAATTEA-GYIDSTI-VRTPESVPEGPPQNCVTGNITGKSFSI 324
S+ + L+P T Y F+++A + G TI RT +S P PPQ + ++ + +
Sbjct: 566 SYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVRV 625
Query: 325 LWDPPTI-----VTGKFSYRVELYGPSGR---ILDN-STKDLKFAFTNLTPFTMYDVYIA 375
W PP V ++S E R ++D S + + L +T Y V++
Sbjct: 626 SWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISREHSSWDLVGLEKWTEYRVWVR 685
Query: 376 AETSAGTGPKSN-ISVFTPPDVP-GAVFDLQLAEVESTQVRITWK--KPRQPNGIINQYR 431
A T G GP+S+ + V T DVP G +++ + ST V + WK P + +G I Y+
Sbjct: 686 AHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQ 745
Query: 432 VKVLVPETG-----IILENTLLTGNNEYINDPMAPEIVNIV--------------EPMV- 471
V + E G I+++ +L E + PE V +P +
Sbjct: 746 VTYVRLENGEPRGLPIIQDVMLAEAQETTISGLTPETTYSVTVAAYTTKGDGARSKPKIV 805
Query: 472 ---GLYEGSAEMSSDLHSLATFIYNSHPDKNFPARNRAEDQTSPVVTTRNQYITDIAAEQ 528
G G M ++ T + HP K P D +
Sbjct: 806 TTTGAVPGRPTMMISTTAMNTALLQWHPPKELPGELLGYRLQYCRADEARPNTIDFGKDD 865
Query: 529 LSYVIRRLVPFTEHMISVSAFTIMGEGPPTVLSVRTRQQVPSSI-KIINYKNISSSSILL 587
+ + L T ++ ++A G G +RT + +PS + ++ +++S+ L
Sbjct: 866 QHFTVTGLHKGTTYIFRLAAKNRAGLGEEFEKEIRTPEDLPSGFPQNLHVTGLTTSTTEL 925
Query: 588 YWDPPEYP--NGKITHYTIYAMELDTNRAFQITTIDNSFLITGLKKYTKYKMRVAASTHV 645
WDPP NG+I YT+ ++++ + Q T D F +TGLK T Y ++V A T
Sbjct: 926 AWDPPVLAERNGRIISYTVVFRDINSQQELQNITTDTRFTLTGLKPDTTYDIKVRAWTSK 985
Query: 646 GESSLSEENDIFVRTSEDEPESSPQDVEVIDVTADEIRLKWSPPEKPNGIIIAYEVLYKN 705
G LS I RT E + ++ V + L W P+ + +++LY N
Sbjct: 986 GSGPLSP--SIQSRTMPVE-QVFAKNFRVAAAMKTSVLLSWEVPDSYKS-AVPFKILY-N 1040
Query: 706 IDTLYMKNTSTTDIILRNLRPHTLYNISVRSYTRFGHGNQVSSLLSVRTSETVPDSAPEN 765
++ + S +I +L+P+T Y S+ G+ L + + T PD P
Sbjct: 1041 GQSVEVDGHSMRKLI-ADLQPNTEY-----SFVLMNRGSSAGGLQHLVSIRTAPDLLPHK 1094
Query: 766 ITYKN--ISSGEIELSFLPPSSPN 787
+ I G +LS P+
Sbjct: 1095 PLPASAYIEDGRFDLSMPHVQDPS 1118
Score = 116 bits (290), Expect = 3e-25
Identities = 122/459 (26%), Positives = 182/459 (39%), Gaps = 60/459 (13%)
Query: 21 VSNVVPGTRYDITI---SSISTTYTSPVTRIVTTNVTKPGPPVFLAGERVGSAGILLSWN 77
+ ++ P T Y + S + +P T T PP + +GS + +SW
Sbjct: 569 LEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVRVSWV 628
Query: 78 TPP--NPNGRIISYIVKYKEVCPWMQTVYTQVRSKPDSLEVLLTNLNPGTTYEIKVAAEN 135
PP + NG I Y V Y+ V + + + L L T Y + V A
Sbjct: 629 PPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISREHSSWDLVGLEKWTEYRVWVRAHT 688
Query: 136 SAGIGVFSDPFLFQTAESAP-GKVVNLTVEAYNASAVKLIWYLP--RQPNGKITSFKISV 192
G G S P L +T E P G + VE N++AV + W LP + +G+I ++++
Sbjct: 689 DVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTY 748
Query: 193 KHARSGI-----VVKDVSIRV--EDILTGKLPECNENSESFLWST----ASPSPTLGRVT 241
+G +++DV + E ++G PE + ++T A P + T
Sbjct: 749 VRLENGEPRGLPIIQDVMLAEAQETTISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTT 808
Query: 242 P--PSRTTHSSSTLTQNEISSVWKEPIS-------------------------------F 268
P R T ST N W P F
Sbjct: 809 GAVPGRPTMMISTTAMNTALLQWHPPKELPGELLGYRLQYCRADEARPNTIDFGKDDQHF 868
Query: 269 VVTHLRPYTTYLFEVSAATTEAGYIDS--TIVRTPESVPEGPPQNCVTGNITGKSFSILW 326
VT L TTY+F + AA AG + +RTPE +P G PQN +T + + W
Sbjct: 869 TVTGLHKGTTYIFRL-AAKNRAGLGEEFEKEIRTPEDLPSGFPQNLHVTGLTTSTTELAW 927
Query: 327 DPPTIVTGK---FSYRVELYG-PSGRILDNSTKDLKFAFTNLTPFTMYDVYIAAETSAGT 382
DPP + SY V S + L N T D +F T L P T YD+ + A TS G+
Sbjct: 928 DPPVLAERNGRIISYTVVFRDINSQQELQNITTDTRFTLTGLKPDTTYDIKVRAWTSKGS 987
Query: 383 GPKS-NISVFTPPDVPGAVFDLQLAEVESTQVRITWKKP 420
GP S +I T P + ++A T V ++W+ P
Sbjct: 988 GPLSPSIQSRTMPVEQVFAKNFRVAAAMKTSVLLSWEVP 1026
Score = 112 bits (281), Expect = 3e-24
Identities = 161/654 (24%), Positives = 262/654 (40%), Gaps = 73/654 (11%)
Query: 1115 LEKYTDYILKITPSTEKGFSDTYTAQLYIKTEEDVPETSPIINTFKNLSSTSVLLSWDPP 1174
L +++Y ++ G A + +T E P + P + LS++++L+ W+PP
Sbjct: 379 LSPFSEYAFRVLAVNSIGRGPPSEA-VRARTGEQAPSSPPRRVQARMLSASTMLVQWEPP 437
Query: 1175 VKPNGAIISYDL-----TLQGPNENYSFITSDNYII-LEELSPFTLYSFFAAARTRKGLG 1228
+PNG + Y + + + PN + T + + L P YS A T G G
Sbjct: 438 EEPNGLVRGYRVYYTPDSRRPPNAWHKHNTDAGLLTTVGSLLPGITYSLRVLAFTAVGDG 497
Query: 1229 PSS-ILFFYTDESVPLAPPQNLTLINCTSDFVWLKWSPSPLPGGIVK--VYSFKIHEHET 1285
P S + T + VP P + + + L W P I+ VY E +
Sbjct: 498 PPSPTIQVKTQQGVPAQPADFQAEVESDTR-IQLSWLLPPQERIIMYELVYWAAEDEDQQ 556
Query: 1286 DTIYYKNISGFKTEAKLVGLEPVSTYSIRVSAFTKVGNGNQFSNVVKFTTQESVPDVV-Q 1344
+ + S + E L+P + Y +++A + +G G F+ ++ T +S P Q
Sbjct: 557 HKVTFDPTSSYTLE----DLKPDTLYRFQLAARSDMGVG-VFTPTIEARTAQSTPSAPPQ 611
Query: 1345 NMQCMATSWQSVLVKWDPPK--KANGIITQYMVTVERNSTK---------VSPQDHMYTF 1393
+ C++ +V V W PP NG+ITQY V E + +S + +
Sbjct: 612 KVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISREHSSWDL 671
Query: 1394 IKLLANTSYVFKVRASTSAGEGDESTCHVSTLPETVPS-VPTNIAFSDVQSTSATLTWIR 1452
+ L T Y VRA T G G ES+ + E VPS P + + ST+ + W
Sbjct: 672 VGLEKWTEYRVWVRAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKL 731
Query: 1453 P--DTILGYFQNYKITTQLRAQKCKEWESEECVEYQKIQYLYEAHLTEETVYGLKKFRWY 1510
P G + Y++T E+ E IQ + A E T+ GL Y
Sbjct: 732 PVPSKQHGQIRGYQVTYV-------RLENGEPRGLPIIQDVMLAEAQETTISGLTPETTY 784
Query: 1511 RFQVAASTNAGYGNASN---WISTKTLPGPPDGPPENVHVVATSPFSISISWSEPAVITG 1567
VAA T G G S +T +PG P + + T+ + + W P + G
Sbjct: 785 SVTVAAYTTKGDGARSKPKIVTTTGAVPGRP-----TMMISTTAMNTALLQWHPPKELPG 839
Query: 1568 PTCYLIDVKSVDNDEFNISFIKSNEEN-KTIEI-KDLEIFTRYSVVI-TAFTGNISAAYV 1624
+ + + +++E TI+ KD + FT + T + ++A
Sbjct: 840 ELL-----------GYRLQYCRADEARPNTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNR 888
Query: 1625 EGKSSA-EMIVTTLESAPKDPPNNMTFQKIPDEVTKFQLTFLPP--SQPNGNIQVYQALV 1681
G E + T E P P N+ + T +L + PP ++ NG I Y +V
Sbjct: 889 AGLGEEFEKEIRTPEDLPSGFPQNLHVTGLTTSTT--ELAWDPPVLAERNGRIISY-TVV 945
Query: 1682 YREDDPTAVQIHNLSIIQKTNTFVIAMLEGLKGGHTYNISVYAVNSAGAGPKVP 1735
+R+ I++ +Q T L GLK TY+I V A S G+GP P
Sbjct: 946 FRD-------INSQQELQNITTDTRFTLTGLKPDTTYDIKVRAWTSKGSGPLSP 992
Score = 80.5 bits (197), Expect = 2e-14
Identities = 155/746 (20%), Positives = 273/746 (36%), Gaps = 119/746 (15%)
Query: 13 GTSETQVDVSNVVPGTRYD---ITISSISTTYTSPVTRIVTTNVTKPGPPVFLAGERVGS 69
G + T+ + + P + Y + ++SI S R T PP + + +
Sbjct: 368 GVATTRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSPPRRVQARMLSA 427
Query: 70 AGILLSWNTPPNPNGRIISYIVKYKEVCPWMQTVYTQVRSKPDSLEVLLTNLNPGTTYEI 129
+ +L+ W P PNG + Y V Y + + + L + +L PG TY +
Sbjct: 428 STMLVQWEPPEEPNGLVRGYRVYYTPDSRRPPNAWHK-HNTDAGLLTTVGSLLPGITYSL 486
Query: 130 KVAAENSAGIGVFSDPFLFQTAESAPGKVVNLTVEAYNASAVKLIWYLPRQPNGKITSFK 189
+V A + G G S +T + P + + E + + ++L W LP P +I ++
Sbjct: 487 RVLAFTAVGDGPPSPTIQVKTQQGVPAQPADFQAEVESDTRIQLSWLLP--PQERIIMYE 544
Query: 190 ISVKHARSGIVVKDV------SIRVEDILTGKLPECNENSESFL--------------WS 229
+ A V S +ED+ L + S + S
Sbjct: 545 LVYWAAEDEDQQHKVTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQS 604
Query: 230 TASPSP------TLGRVT-----PPSRTTHSSSTLTQNEIS---------------SVWK 263
T S P ++G T P + +TQ ++ + +
Sbjct: 605 TPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISR 664
Query: 264 EPISFVVTHLRPYTTYLFEVSAATTEAGYIDST--IVRTPESVPEGPPQNCVTGNITGKS 321
E S+ + L +T Y V A T +S+ +VRT E VP GPP+ + +
Sbjct: 665 EHSSWDLVGLEKWTEYRVWVRAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTA 724
Query: 322 FSILWDPPTIVTGKFSYRVELYGPSGRILDNS-------TKDLKFA------FTNLTPFT 368
+ W P V K ++ Y + L+N +D+ A + LTP T
Sbjct: 725 VHVYWKLP--VPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQETTISGLTPET 782
Query: 369 MYDVYIAAETSAGTGPKSNISVFTPPD-VPGAVFDLQLAEVESTQVRITWKKPRQPNGII 427
Y V +AA T+ G G +S + T VPG + ++ + W P++ G +
Sbjct: 783 TYSVTVAAYTTKGDGARSKPKIVTTTGAVPGRP-TMMISTTAMNTALLQWHPPKELPGEL 841
Query: 428 NQYRVKVLVPETGIILENTLLTGNNE-------------YINDPMAPEIVNIVEPMVGLY 474
YR++ + NT+ G ++ YI A + E +
Sbjct: 842 LGYRLQYCRADEA--RPNTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGLGEE----F 895
Query: 475 EGSAEMSSDLHSLATFIYNSHPDKNFPARNRAEDQTSPVVTTRNQYI-------TDIAAE 527
E DL S F N H PV+ RN I DI ++
Sbjct: 896 EKEIRTPEDLPS--GFPQNLHV-TGLTTSTTELAWDPPVLAERNGRIISYTVVFRDINSQ 952
Query: 528 Q--------LSYVIRRLVPFTEHMISVSAFTIMGEGPPTVLSVRTRQQVPSSIKIINYKN 579
Q + + L P T + I V A+T G GP + S+++R + N++
Sbjct: 953 QELQNITTDTRFTLTGLKPDTTYDIKVRAWTSKGSGPLSP-SIQSRTMPVEQVFAKNFRV 1011
Query: 580 ISS--SSILLYWDPPEYPNGKITHYTIYAMELDTNRAFQITTIDNSFLITGLKKYTKYKM 637
++ +S+LL W+ P+ + +Y ++ ++ LI L+ T+Y
Sbjct: 1012 AAAMKTSVLLSWEVPDSYKSAVPFKILY-----NGQSVEVDGHSMRKLIADLQPNTEYSF 1066
Query: 638 RVAASTHVGESSLSEENDIFVRTSED 663
+ G S+ ++ + +RT+ D
Sbjct: 1067 ---VLMNRGSSAGGLQHLVSIRTAPD 1089
Score = 75.9 bits (185), Expect = 4e-13
Identities = 73/328 (22%), Positives = 134/328 (40%), Gaps = 41/328 (12%)
Query: 18 QVDVSNVVPGTRYDITISSISTTYTSPVTR--IVTTNVTKPGPPVFLAGERVGSAGILLS 75
+ +S + P T Y +T+++ +T ++ IVTT PG P + + LL
Sbjct: 772 ETTISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTTGAVPGRPTMMISTTAMNTA-LLQ 830
Query: 76 WNTPPNPNGRIISYIVKYKEVCPWMQTVYTQVRSKPDSLEVLLTNLNPGTTYEIKVAAEN 135
W+ P G ++ Y ++Y C + + D +T L+ GTTY ++AA+N
Sbjct: 831 WHPPKELPGELLGYRLQY---CRADEARPNTIDFGKDDQHFTVTGLHKGTTYIFRLAAKN 887
Query: 136 SAGIGVFSDPFLFQTAESAPGKVVNLTVEAYNASAVKLIWYLP--RQPNGKITSFKISVK 193
AG+G + + + G NL V S +L W P + NG+I S+ + +
Sbjct: 888 RAGLGEEFEKEIRTPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFR 947
Query: 194 HARSGIVVKDVSIRVEDILTGKLPECNENSESFLWSTASP---SPTLGRVTPPSRTTHS- 249
S +++++ LTG P+ + + W++ SP++ T P +
Sbjct: 948 DINSQQELQNITTDTRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVEQVFAK 1007
Query: 250 ---------SSTLTQNEISSVWKEPISF------------------VVTHLRPYTTYLFE 282
+S L E+ +K + F ++ L+P T Y F
Sbjct: 1008 NFRVAAAMKTSVLLSWEVPDSYKSAVPFKILYNGQSVEVDGHSMRKLIADLQPNTEYSFV 1067
Query: 283 VSAATTEAGYIDSTI-VRT-PESVPEGP 308
+ + AG + + +RT P+ +P P
Sbjct: 1068 LMNRGSSAGGLQHLVSIRTAPDLLPHKP 1095
>gi|4506309 protein tyrosine phosphatase, receptor type, D isoform 1
precursor [Homo sapiens]
Length = 1912
Score = 248 bits (634), Expect = 4e-65
Identities = 155/446 (34%), Positives = 240/446 (53%), Gaps = 25/446 (5%)
Query: 1861 NGPLKPKKQYLFKFRATNIMGQ---FTDSDYSDPVKTLGEGLSERTVEI-----ILSVTL 1912
N L+ ++Y+F A + + S YSDPV ++ T E ++ L
Sbjct: 1216 NKQLQSGQEYVFFVLAVMEHAESKMYATSPYSDPVVSMDLDPQPITDEEEGLIWVVGPVL 1275
Query: 1913 CILSIILLGTAIFAFARIRQKQKEGGTYSPQDAEIIDTKLKLDQLITVADLELKDERLTR 1972
++ II + AI + R R + + P + EI +EL+ RL
Sbjct: 1276 AVVFIICIVIAILLYKRKRAESDSRKSSIPNNKEIPSHH-------PTDPVELR--RLNF 1326
Query: 1973 LLSYRKSIKPISKKSFLQHVEELCTNNNLKFQEEFSELPKFLQDLSSTDADLPWNRAKNR 2032
S PI H+E L N+NLKF +E+ + Q + ++L N+ KNR
Sbjct: 1327 QTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPG-QQFTWEHSNLEVNKPKNR 1385
Query: 2033 FPNIKPYNNNRVKLIADASVPGSDYINASYISGYLCPNEFIATQGPLPGTVGDFWRMVWE 2092
+ N+ Y+++RV L A +PGSDY+NA+YI GY N +IATQG LP T GDFWRM+WE
Sbjct: 1386 YANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWE 1445
Query: 2093 TRAKTLVMLTQCFEKGRIRCHQYWPEDNKPVTVFGDIVITKLMEDVQI-DWTIRDLKIER 2151
R+ T+VM+T+ E+ R++C QYWP ++ G + +T L++ V++ + +R + +
Sbjct: 1446 QRSATVVMMTKLEERSRVKCDQYWP--SRGTETHGLVQVT-LLDTVELATYCVRTFALYK 1502
Query: 2152 HG--DCMTVRQCNFTAWPEHGVPENSAPLIHFVKLVRASRAHDTTPMIVHCSAGVGRTGV 2209
+G + VRQ FTAWP+HGVPE+ P + F++ V+ D PM+VHCSAGVGRTG
Sbjct: 1503 NGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGC 1562
Query: 2210 FIALDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLLSNKGSNQPI 2269
FI +D + + I VDIYG V +R++R MVQ QYIF+H +L+ ++ + P
Sbjct: 1563 FIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPA 1622
Query: 2270 CFVNYSALQKMDSLDAMEGDVELEWE 2295
+ Y+ +QK+ ++ E +E E
Sbjct: 1623 RNL-YAYIQKLTQIETGENVTGMELE 1647
Score = 223 bits (567), Expect = 2e-57
Identities = 225/839 (26%), Positives = 363/839 (43%), Gaps = 71/839 (8%)
Query: 581 SSSSILLYWDP--PEYPNGKITHYTIYAMELDTNRAFQIT--TIDNSFLITGLKKYTKYK 636
+++SI L WD PE +++Y I ++ ++ + + GL Y+ Y+
Sbjct: 335 TATSITLTWDSGNPE----PVSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYE 390
Query: 637 MRVAASTHVGESSLSEENDIFVRTSEDEPESSPQDVEVIDVTADEIRLKWSPPEKPNGII 696
RV A ++G SE + +TSE P S+P+DV+ +++ I ++W PE+PNG I
Sbjct: 391 FRVVAVNNIGRGPPSEP--VLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQI 448
Query: 697 IAYEVLYKNIDTLYMKNTSTTDII------LRNLRPHTLYNISVRSYTRFGHGNQVSSLL 750
Y V Y T ++ N ++ + NL P Y++ V ++T G G +SS +
Sbjct: 449 QGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDG-PLSSDI 507
Query: 751 SVRTSETVPDSAPENITYKNISSGEIELSFLPPSSPNGIIQKYTIYLKRSNGNEERTINT 810
V T VP P N + S I LS+ PP S I +Y +G E+R
Sbjct: 508 QVITQTGVPGQ-PLNFKAEPESETSILLSWTPPRSDT-IANYELVYKDGEHGEEQRITIE 565
Query: 811 TSLTQNIKVLKKYTQYIIEVSASTLKGEGVRSAPISILTEEDAPDSPPQDFSVKQLSGVT 870
+ ++ LK + Y ++A + +G G +A IS T + P +PPQD S S +
Sbjct: 566 PGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTS 625
Query: 871 VKLSWQPP--LEPNGIILYYTVYVW-------NRSSLKTINVTETSLELSDLDYNVEYSA 921
+ +SWQPP + NGII Y++ + I T L L+ EY
Sbjct: 626 ILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRI 685
Query: 922 YVTASTRFGDGKTRSNIISFQTPEGAPSDPPKDVYYANLSSSSIILFWTP--PSKPNGII 979
VTA T G G +++ +T E PS PP+ V ++S+S+ + W P+K +G I
Sbjct: 686 TVTAHTDVGPGPESLSVL-IRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQI 744
Query: 980 QYYSVYY-RNTSG-----TFMQNFTLHEVTNDFDNMTV-STIIDKLTIFSYYTFWLTAST 1032
+ Y V+Y R +G +++ L + +FD+ T II L + Y+ +TA T
Sbjct: 745 RGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYT 804
Query: 1033 SVGNGNKSSDIIEVYTDQDIPEGFVGNLTYESISSTAINVSWVPPAQPNGLVFYYVSLIL 1092
+ G+G +S + V T +P G + + +TA+ + W PP G + Y
Sbjct: 805 TKGDGARSKPKL-VSTTGAVP-GKPRLVINHTQMNTAL-IQWHPPVDTFGPLQGY----R 857
Query: 1093 QQTPRHVRPPLVTYERSIYFD-----NLEKYTDYILKITPSTEKGFSDTYTAQLYIKTEE 1147
+ R PL T E S D ++ K Y+ +++ + GF + ++ I E
Sbjct: 858 LKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEEMVKEISI--PE 915
Query: 1148 DVPETSPIINTFKNLSSTSVLLSWDPPV--KPNGAIISYDLTLQGPN-----ENYSFITS 1200
+VP P + +STSV LSW PPV + NG I Y L + N + +
Sbjct: 916 EVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPA 975
Query: 1201 DNYIILEELSPFTLYSFFAAARTRKGLGPSSILFFYTDESVPLAPPQNLTLINCTSDFVW 1260
D + L L P T Y A T KG GP S + V +N + V
Sbjct: 976 DTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVFAKNFHVKAVMKTSVL 1035
Query: 1261 LKWSPSPLPGGIVKVYSFKIHEHETDTIYYKNISGFKTEAKLVGLEPVSTYSIRVSAFTK 1320
L W +P FKI + + + + G T+ +V L+P +YS F
Sbjct: 1036 LSWE---IPENYNSAMPFKILYDDGKMV--EEVDGRATQKLIVNLKPEKSYS-----FVL 1085
Query: 1321 VGNGNQFSNVVKFTTQESVPDVVQNMQCM--ATSWQSVLVKWDPPKKANGIITQYMVTV 1377
GN + T ++ PDV++ T+ ++ P AN I Y + +
Sbjct: 1086 TNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPANENIKGYYIII 1144
Score = 214 bits (544), Expect = 1e-54
Identities = 201/711 (28%), Positives = 328/711 (46%), Gaps = 89/711 (12%)
Query: 531 YVIRRLVPFTEHMISVSAFTIMGEGPPTV-LSVRTRQQVPSSI-KIINYKNISSSSILLY 588
Y + L P++++ V A +G GPP+ + +T +Q PSS + + + +SS++IL+
Sbjct: 378 YSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQ 437
Query: 589 WDPPEYPNGKITHYTIYAMELDTNRA----------FQITTIDNSFLITGLKKYTKYKMR 638
W PE PNG+I Y +Y T QITTI N L Y ++
Sbjct: 438 WKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGN------LVPQKTYSVK 491
Query: 639 VAASTHVGESSLSEENDIFVRTSEDEPESSPQDVEVIDVTADEIRLKWSPPEKPNGIIIA 698
V A T +G+ LS +DI V T P P + + + I L W+PP + I
Sbjct: 492 VLAFTSIGDGPLS--SDIQVITQTGVP-GQPLNFKAEPESETSILLSWTPPR--SDTIAN 546
Query: 699 YEVLYKNIDTLYMKNTST---TDIILRNLRPHTLYNISVRSYTRFGHGNQVSSLLSVRTS 755
YE++YK+ + + + T L+ L+P++LY + + + G G + +S RT
Sbjct: 547 YELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAE-ISARTM 605
Query: 756 ETVPDSAPENITYKNISSGEIELSFLPP--SSPNGIIQKYTIYLKRSNGNEERT-----I 808
++ P + P++I+ + SS I +S+ PP NGII +Y+I +G +++ I
Sbjct: 606 QSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGI 665
Query: 809 NTTSLTQNIKVLKKYTQYIIEVSASTLKGEGVRSAPISILTEEDAPDSPPQDFSVKQLSG 868
+ + ++ L+K+T+Y I V+A T G G S + I T ED P PP+ V+ ++
Sbjct: 666 PSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNS 725
Query: 869 VTVKLSWQPPL--EPNGIILYYTVYVWNRSS--------LKTI----------NVTETSL 908
+VK+SW+ P+ + +G I Y V+ + LK + + TE +
Sbjct: 726 TSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDM 785
Query: 909 ELSDLDYNVEYSAYVTASTRFGDGKTRSNIISFQTPEGAPSDPPKDVYYANLSSSSIILF 968
+S L YS VTA T GDG RS T P P + + ++++ ++
Sbjct: 786 IISGLQPETSYSLTVTAYTTKGDG-ARSKPKLVSTTGAVPGKPRLVINHTQMNTA--LIQ 842
Query: 969 WTPPSKPNGIIQYYSVYYRNTSGTFMQNFTLHEVTNDFDNMTVSTIIDKLTIFSYYTFWL 1028
W PP G +Q Y + + M+ T E + D+ T + I + Y F L
Sbjct: 843 WHPPVDTFGPLQGYRLKFGRKD---MEPLTTLEFSEKEDHFTATDIHKGAS----YVFRL 895
Query: 1029 TASTSVGNGNKSSDIIEVYTDQDIPEGFVGNLTYESISSTAINVSWVPP--AQPNGLVFY 1086
+A VG G + + E+ +++P GF NL E +ST++ +SW PP A+ NG++
Sbjct: 896 SARNKVGFGEEM--VKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITK 953
Query: 1087 YVSLILQQTPRHVRPPLVTYERSIY-------FDNLEKYTDYILKITPSTEKGFSDTYTA 1139
Y L R + PL+ E+ I L+ T Y +K+ T KG Y+
Sbjct: 954 YTLLY-----RDINIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKG-PGPYSP 1007
Query: 1140 QLYIKTEEDVPETSPIINTF--KNLSSTSVLLSWDPPVKPNGAI---ISYD 1185
+ +T +P F K + TSVLLSW+ P N A+ I YD
Sbjct: 1008 SVQFRT---LPVDQVFAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYD 1055
Score = 193 bits (490), Expect = 2e-48
Identities = 114/282 (40%), Positives = 155/282 (54%), Gaps = 8/282 (2%)
Query: 1987 SFLQHVEELCTNNNLKFQE-EFSELPKFLQDLSS-TDADLPWNRAKNRFPNIKPYNNNRV 2044
+++Q + ++ T N+ E EF L S A+LP N+ KNR NI PY + RV
Sbjct: 1627 AYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRV 1686
Query: 2045 KLIADASVPGSDYINASYISGYLCPNEFIATQGPLPGTVGDFWRMVWETRAKTLVMLTQC 2104
L V GSDYINAS+I GY +IATQGPL T DFWRM+WE + +VMLT+
Sbjct: 1687 CLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKL 1746
Query: 2105 FEKGRIRCHQYWPEDNKPVTVFGDIVITKLMEDVQIDWTIRDLKI--ERHGDCMTVRQCN 2162
E GR +CHQYWP + + V+ + E + +R+ K+ R G TVRQ
Sbjct: 1747 REMGREKCHQYWPAERS--ARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQ 1804
Query: 2163 FTAWPEHGVPENSAPLIHFVKLVRASRAH--DTTPMIVHCSAGVGRTGVFIALDHLTQHI 2220
FT WPE GVP++ I F+ V ++ P+ VHCSAGVGRTGVFI L + + +
Sbjct: 1805 FTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERM 1864
Query: 2221 NDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLLSN 2262
VDI+ V LR++R MVQ QY F ++ L+ L +
Sbjct: 1865 RYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGS 1906
Score = 191 bits (486), Expect = 5e-48
Identities = 215/776 (27%), Positives = 343/776 (44%), Gaps = 80/776 (10%)
Query: 830 VSASTLKGEGVRSAPISILTEEDAPDSPPQDFSVKQLSGVTVKLSWQPPL-EPNGIILYY 888
V+ STL GV A I+ +T + P PP V + + ++ L+W EP + YY
Sbjct: 303 VAMSTL---GVIEA-IAQITVKALP-KPPGTPVVTESTATSITLTWDSGNPEP---VSYY 354
Query: 889 TVYVWNRSS---LKTIN-VTETSLELSDLDYNVEYSAYVTASTRFGDGKTRSNIISFQTP 944
+ ++S K I+ V T ++ L +Y V A G G +++ QT
Sbjct: 355 IIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLT-QTS 413
Query: 945 EGAPSDPPKDVYYANLSSSSIILFWTPPSKPNGIIQYYSVYYRNTSGTFMQNFTLHEVTN 1004
E APS P+DV LSS++I++ W P +PNG IQ Y VYY + N+ H V
Sbjct: 414 EQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVA- 472
Query: 1005 DFDNMTVSTIIDKLTIFSYYTFWLTASTSVGNGNKSSDIIEVYTDQDIPEGFVGNLTYES 1064
D T+ ++ + T Y+ + A TS+G+G SSDI +V T +P G N E
Sbjct: 473 DSQITTIGNLVPQKT----YSVKVLAFTSIGDGPLSSDI-QVITQTGVP-GQPLNFKAEP 526
Query: 1065 ISSTAINVSWVPPAQPNGLVFYYVSLILQQTPRHVRPPLVTYE--RSIYFDNLEKYTDYI 1122
S T+I +SW PP + + + Y ++ + H +T E S L+ + Y
Sbjct: 527 ESETSILLSWTPP-RSDTIANYE---LVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYY 582
Query: 1123 LKITPSTEKGFSDTYTAQLYIKTEEDVPETSPIINTFKNLSSTSVLLSWDPPV--KPNGA 1180
++ + +G + TA++ +T + P P + + SSTS+L+SW PP K NG
Sbjct: 583 FRLAARSPQGLGAS-TAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGI 641
Query: 1181 IISYDLTLQG-------PNENYSFITSDNYIILEELSPFTLYSFFAAARTRKGLGPSSI- 1232
I Y + P+E + +LE+L +T Y A T G GP S+
Sbjct: 642 ITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLS 701
Query: 1233 LFFYTDESVPLAPPQNLTLINCTSDFVWLKWSPSPLPGGIV-KVYSFKIHEHETDTIYYK 1291
+ T+E VP PP+ + + S V + W SP+P ++ +++H + K
Sbjct: 702 VLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWR-SPVPNKQHGQIRGYQVHYVRMENGEPK 760
Query: 1292 NISGFK--------------TEAKLV--GLEPVSTYSIRVSAFTKVGNGNQFSNVVKFTT 1335
K TE ++ GL+P ++YS+ V+A+T G+G + + TT
Sbjct: 761 GQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTT 820
Query: 1336 QE--SVPDVVQNMQCMATSWQSVLVKWDPPKKANGIITQYMVTVERN------STKVSPQ 1387
P +V N M T+ L++W PP G + Y + R + + S +
Sbjct: 821 GAVPGKPRLVINHTQMNTA----LIQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEK 876
Query: 1388 DHMYTFIKLLANTSYVFKVRASTSAGEGDESTCHVSTLPETVPS-VPTNIAFSDVQSTSA 1446
+ +T + SYVF++ A G G+E +S +PE VP+ P N+ STS
Sbjct: 877 EDHFTATDIHKGASYVFRLSARNKVGFGEEMVKEIS-IPEEVPTGFPQNLHSEGTTSTSV 935
Query: 1447 TLTWIRPDTILGYFQNYKITTQLRAQKCKEWESEECVEYQKIQYLYEAHLTEETVYGLKK 1506
L+W P +L +N IT + + + ++ L T T+ GLK
Sbjct: 936 QLSWQPP--VLAE-RNGIITKYTLLYR------DINIPLLPMEQLIVPADTTMTLTGLKP 986
Query: 1507 FRWYRFQVAASTNAGYGNASNWISTKTLPGPPDGPPENVHVVATSPFSISISWSEP 1562
Y +V A T+ G G S + +TLP +N HV A S+ +SW P
Sbjct: 987 DTTYDVKVRAHTSKGPGPYSPSVQFRTLP-VDQVFAKNFHVKAVMKTSVLLSWEIP 1041
Score = 183 bits (464), Expect = 2e-45
Identities = 213/798 (26%), Positives = 326/798 (40%), Gaps = 95/798 (11%)
Query: 790 IQKYTIYLKRSNGNE-ERTINTTSLTQ-NIKVLKKYTQYIIEVSASTLKGEGVRSAPISI 847
+ Y I K N E + I+ + T+ ++ L Y+ Y V A G G S P+
Sbjct: 351 VSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLT 410
Query: 848 LTEEDAPDSPPQDFSVKQLSGVTVKLSWQPPLEPNGIILYYTVYV----------WNRSS 897
T E AP S P+D + LS T+ + W+ P EPNG I Y VY W + +
Sbjct: 411 QTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHN 470
Query: 898 LKTINVTETSLELSDLDYNVEYSAYVTASTRFGDGKTRSNIISFQTPEGAPSDPPKDVYY 957
+ +T + +L YS V A T GDG S+ I T G P P +
Sbjct: 471 VADSQIT----TIGNLVPQKTYSVKVLAFTSIGDGPLSSD-IQVITQTGVPGQ-PLNFKA 524
Query: 958 ANLSSSSIILFWTPPSKPNGIIQYYSVYYRNTSGTFMQNFTLHEVTNDFDNMTVSTIIDK 1017
S +SI+L WTPP + I Y + Y++ Q T+ T S +
Sbjct: 525 EPESETSILLSWTPPR--SDTIANYELVYKDGEHGEEQRITIEPGT--------SYRLQG 574
Query: 1018 LTIFSYYTFWLTASTSVGNGNKSSDIIEVYTDQDIPEGFVGNLTYESISSTAINVSWVPP 1077
L S Y F L A + G G +++ I T Q P +++ S SST+I VSW PP
Sbjct: 575 LKPNSLYYFRLAARSPQGLGASTAE-ISARTMQSKPSAPPQDISCTSPSSTSILVSWQPP 633
Query: 1078 --AQPNGLV----FYYVSLILQQTPRHVRPPLVTYERSIYFDNLEKYTDYILKITPSTEK 1131
+ NG++ Y ++ + H + + + LEK+T+Y + +T T+
Sbjct: 634 PVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDV 693
Query: 1132 GFSDTYTAQLYIKTEEDVPETSPIINTFKNLSSTSVLLSWDPPV---------------- 1175
G + + I+T EDVP P + ++STSV +SW PV
Sbjct: 694 G-PGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYV 752
Query: 1176 -----KPNGAIISYDLTLQGPNENYSFITSDNYIILEELSPFTLYSFFAAARTRKGLGP- 1229
+P G + D+ L + T+++ +I+ L P T YS A T KG G
Sbjct: 753 RMENGEPKGQPMLKDVMLADAQWEFD-DTTEHDMIISGLQPETSYSLTVTAYTTKGDGAR 811
Query: 1230 SSILFFYTDESVPLAPPQNLTLINCTSDFVWLKWSPSPLPGGIVKVYSFKIHEHETDTIY 1289
S T +VP P L + + + ++W P G ++ Y K + + +
Sbjct: 812 SKPKLVSTTGAVPGKP--RLVINHTQMNTALIQWHPPVDTFGPLQGYRLKFGRKDMEPLT 869
Query: 1290 YKNISGFKTEAKLVGLEPVSTYSIRVSAFTKVGNGNQFSNVVKFTTQESVP-DVVQNMQC 1348
S + + ++Y R+SA KVG G + V + + E VP QN+
Sbjct: 870 TLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEEM--VKEISIPEEVPTGFPQNLHS 927
Query: 1349 MATSWQSVLVKWDPPKKA--NGIITQYM-------VTVERNSTKVSPQDHMYTFIKLLAN 1399
T+ SV + W PP A NGIIT+Y + + + P D T L +
Sbjct: 928 EGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPADTTMTLTGLKPD 987
Query: 1400 TSYVFKVRASTSAGEGDES-TCHVSTLPETVPSV-PTNIAFSDVQSTSATLTWIRPDTIL 1457
T+Y KVRA TS G G S + TLP V V N V TS L+W P
Sbjct: 988 TTYDVKVRAHTSKGPGPYSPSVQFRTLP--VDQVFAKNFHVKAVMKTSVLLSWEIP---- 1041
Query: 1458 GYFQNYKITTQLRAQKCKEWESEECVEYQKIQYLYEAHLTEETVYGLKKFRWYRFQVAAS 1517
+NY + ++ + VE + T++ + LK + Y F +
Sbjct: 1042 ---ENYNSAMPFKIL----YDDGKMVEE------VDGRATQKLIVNLKPEKSYSFVLTNR 1088
Query: 1518 TNAGYGNASNWISTKTLP 1535
N+ G + ++ KT P
Sbjct: 1089 GNSA-GGLQHRVTAKTAP 1105
Score = 178 bits (451), Expect = 6e-44
Identities = 198/771 (25%), Positives = 338/771 (43%), Gaps = 91/771 (11%)
Query: 286 ATTEAGYIDSTIVRTPESVPEGPPQNCVTGNITGKSFSILWDPPT-------IVTGKFSY 338
A + G I++ T +++P+ PP V T S ++ WD I+ K
Sbjct: 304 AMSTLGVIEAIAQITVKALPK-PPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKN 362
Query: 339 RVELYGPSGRILDNSTKDLKFAFTNLTPFTMYDVYIAAETSAGTGPKSN-ISVFTPPDVP 397
ELY + +++ L+P++ Y+ + A + G GP S + T P
Sbjct: 363 SEELYKEIDGVATT-----RYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAP 417
Query: 398 G-AVFDLQLAEVESTQVRITWKKPRQPNGIINQYRVKVLVPETGII---LENTLLTGNNE 453
A D+Q + ST + + WK+P +PNG I YRV + T + +++ +
Sbjct: 418 SSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQIT 477
Query: 454 YINDPMAPEIVNIVEPMVGLYEGSAEMSSDLHSLATFIYNSHPDKNFPARNRAEDQTSPV 513
I + + P+ V+ + G +SSD+ + P NF A E +TS +
Sbjct: 478 TIGN-LVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQP-LNFKA--EPESETSIL 533
Query: 514 VTTRNQYITDIAAEQL-------------------SYVIRRLVPFTEHMISVSAFTIMGE 554
++ IA +L SY ++ L P + + ++A + G
Sbjct: 534 LSWTPPRSDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGL 593
Query: 555 GPPTV-LSVRTRQQVPSS-IKIINYKNISSSSILLYWDPP--EYPNGKITHYTI--YAME 608
G T +S RT Q PS+ + I+ + SS+SIL+ W PP E NG IT Y+I A++
Sbjct: 594 GASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVD 653
Query: 609 LDTNRAFQITTIDN---SFLITGLKKYTKYKMRVAASTHVGESSLSEENDIFVRTSEDEP 665
+ ++ +I I + +L+ L+K+T+Y++ V A T VG E + +RT+ED P
Sbjct: 654 GEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPG--PESLSVLIRTNEDVP 711
Query: 666 ESSPQDVEVIDVTADEIRLKW-SP-PEKPNGIIIAYEVLYKNIDTLYMK----------- 712
P+ VEV V + +++ W SP P K +G I Y+V Y ++ K
Sbjct: 712 SGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLA 771
Query: 713 -------NTSTTDIILRNLRPHTLYNISVRSYTRFGHGNQVSSLLSVRTSETVPDSAPEN 765
+T+ D+I+ L+P T Y+++V +YT G G + L V T+ VP
Sbjct: 772 DAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKL-VSTTGAVPGKPRLV 830
Query: 766 ITYKNISSGEIELSFLPPSSPNGIIQKYTIYLKRSNGNEERTINTTSLTQNIKV--LKKY 823
I + +++ I+ + PP G +Q Y + R + T+ + + + K
Sbjct: 831 INHTQMNTALIQ--WHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKG 888
Query: 824 TQYIIEVSASTLKGEGVRSAPISILTEEDAPDSPPQDFSVKQLSGVTVKLSWQPPL--EP 881
Y+ +SA G G I E+ P PQ+ + + +V+LSWQPP+ E
Sbjct: 889 ASYVFRLSARNKVGFGEEMVK-EISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAER 947
Query: 882 NGIILYYTVYVWNRS-----SLKTINVTETSLELSDLDYNVEYSAYVTASTRFGDGKTRS 936
NGII YT+ + + + I +T++ L+ L + Y V A T G G S
Sbjct: 948 NGIITKYTLLYRDINIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPG-PYS 1006
Query: 937 NIISFQTPEGAPSDP--PKDVYYANLSSSSIILFWTPPSKPNGIIQYYSVY 985
+ F+T P D K+ + + +S++L W P N + + +Y
Sbjct: 1007 PSVQFRT---LPVDQVFAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILY 1054
Score = 153 bits (387), Expect = 2e-36
Identities = 181/763 (23%), Positives = 308/763 (40%), Gaps = 93/763 (12%)
Query: 908 LELSDLDYNVEYSAYVTASTRFGDGKTRSNIISFQTPEGAPSDPPKDVYYANLSSSSIIL 967
LEL+D+ + Y+ ++ + + + + P G P +++SI L
Sbjct: 289 LELNDVRQSANYTCVAMSTLGVIEAIAQITVKALPKPPGTP-------VVTESTATSITL 341
Query: 968 FWTPPSKPNGIIQYYSVYYRNTSGTFMQNFTLHEVTNDFDNM-TVSTIIDKLTIFSYYTF 1026
W + + YY + ++ + E+ + D + T + L+ +S Y F
Sbjct: 342 TWDSGNPEP--VSYYIIQHKPKNS--------EELYKEIDGVATTRYSVAGLSPYSDYEF 391
Query: 1027 WLTASTSVGNGNKSSDIIEVYTDQDIPEGFVGNLTYESISSTAINVSWVPPAQPNGLVFY 1086
+ A ++G G S ++ T + P ++ +SST I V W P +PNG +
Sbjct: 392 RVVAVNNIGRGPPSEPVL-TQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQG 450
Query: 1087 YVSLILQQTPRHVRPPL---VTYERSIYFDNLEKYTDYILKITPSTEKGFSDTYTAQLYI 1143
Y +HV + V + NL Y +K+ T G ++ + +
Sbjct: 451 YRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIG-DGPLSSDIQV 509
Query: 1144 KTEEDVPETSPIINTFKNLSSTSVLLSWDPPVKPNGAIISYDLTLQ----GPNENYSFIT 1199
T+ VP P+ + S TS+LLSW PP + I +Y+L + G + +
Sbjct: 510 ITQTGVPG-QPLNFKAEPESETSILLSWTPP--RSDTIANYELVYKDGEHGEEQRITIEP 566
Query: 1200 SDNYIILEELSPFTLYSFFAAARTRKGLGPSSI-LFFYTDESVPLAPPQNLTLINCTSDF 1258
+Y L+ L P +LY F AAR+ +GLG S+ + T +S P APPQ+++ + +S
Sbjct: 567 GTSYR-LQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTS 625
Query: 1259 VWLKWSPSPLP--GGIVKVYSFKIHEHETDTIYYKNISGFKTEAK---LVGLEPVSTYSI 1313
+ + W P P+ GI+ YS K + + I G ++ L LE + Y I
Sbjct: 626 ILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRI 685
Query: 1314 RVSAFTKVGNGNQFSNVVKFTTQESVPDVVQNMQCMATSWQSVLVKWDPP--KKANGIIT 1371
V+A T VG G + +V+ T ++ + ++ A + SV V W P K +G I
Sbjct: 686 TVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIR 745
Query: 1372 QYMV---TVERNSTKVSPQ-----------------DHMYTFIKLLANTSYVFKVRASTS 1411
Y V +E K P +H L TSY V A T+
Sbjct: 746 GYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTT 805
Query: 1412 AGEGDESTCHVSTLPETVPSVPTNIAFSDVQSTSATLTWIRPDTILGYFQNYKITTQLRA 1471
G+G S + + VP P + + Q +A + W P G Q Y++
Sbjct: 806 KGDGARSKPKLVSTTGAVPGKP-RLVINHTQMNTALIQWHPPVDTFGPLQGYRLKFGR-- 862
Query: 1472 QKCKEWESEECVEYQKIQYLYEAHLTEETVYGLKKFRWYRFQVAASTNAGYGNASNWIST 1531
K+ E +E+ + E H T ++ K Y F+++A G+G +
Sbjct: 863 ---KDMEPLTTLEFSE----KEDHFTATDIH---KGASYVFRLSARNKVGFGE--EMVKE 910
Query: 1532 KTLPGP-PDGPPENVHVVATSPFSISISWSEP------AVITGPTCYLIDVKSVDNDEFN 1584
++P P G P+N+H T+ S+ +SW P +IT T D+ N
Sbjct: 911 ISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDI--------N 962
Query: 1585 ISFIKSNE----ENKTIEIKDLEIFTRYSVVITAFTGNISAAY 1623
I + + + T+ + L+ T Y V + A T Y
Sbjct: 963 IPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPY 1005
Score = 135 bits (340), Expect = 5e-31
Identities = 195/859 (22%), Positives = 324/859 (37%), Gaps = 147/859 (17%)
Query: 13 GTSETQVDVSNVVPGTRYDITISSISTTYTSPVTRIVTTNVTKPGP---PVFLAGERVGS 69
G + T+ V+ + P + Y+ + +++ P + V T ++ P P + + S
Sbjct: 372 GVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSS 431
Query: 70 AGILLSWNTPPNPNGRIISYIVKY-----KEVCPWMQTVYTQVRSKPDSLEVLLTNLNPG 124
IL+ W P PNG+I Y V Y + V WM+ + DS + NL P
Sbjct: 432 TTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMK------HNVADSQITTIGNLVPQ 485
Query: 125 TTYEIKVAAENSAGIGVFSDPFLFQTAESAPGKVVNLTVEAYNASAVKLIWYLPRQPNGK 184
TY +KV A S G G S T PG+ +N E + +++ L W PR +
Sbjct: 486 KTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPR--SDT 543
Query: 185 ITSFKISVKHARSGIVVKDVSIRVEDILTGKLPECNENSESFLWSTASPSPTLGRVTPPS 244
I ++++ K G ++ I +E + +L NS + A LG T
Sbjct: 544 IANYELVYKDGEHG---EEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTA-- 598
Query: 245 RTTHSSSTLTQNEISSVWKEPISFVVTHLRPYTTYLFEVSAATTEAGYIDSTIVRTPESV 304
E+SA T + S
Sbjct: 599 -------------------------------------EISARTMQ-------------SK 608
Query: 305 PEGPPQNCVTGNITGKSFSILWDPPTIVTGK---FSYRVELYGPSG------RILDNSTK 355
P PPQ+ + + S + W PP + Y ++ G IL +
Sbjct: 609 PSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSD 668
Query: 356 DLKFAFTNLTPFTMYDVYIAAETSAGTGPKS-NISVFTPPDVP-GAVFDLQLAEVESTQV 413
K+ L +T Y + + A T G GP+S ++ + T DVP G +++ V ST V
Sbjct: 669 TTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSV 728
Query: 414 RITWKK--PRQPNGIINQYRVKVLVPETG-----IILENTLL---------TGNNEYIND 457
+++W+ P + +G I Y+V + E G +L++ +L T ++ I
Sbjct: 729 KVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIIS 788
Query: 458 PMAPEIVNIVEPMVGLYEGSAEMSSDLHSLATFIYNSHPDK--NFPARNRAEDQTSPVVT 515
+ PE + +G S T P N N A Q P V
Sbjct: 789 GLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNTALIQWHPPVD 848
Query: 516 TRNQYITDIAAEQLSYVIRRLVPFT--------------------EHMISVSAFTIMGEG 555
T + +L + + + P T ++ +SA +G G
Sbjct: 849 T----FGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFG 904
Query: 556 PPTVLSVRTRQQVPSSI-KIINYKNISSSSILLYWDPPEYP--NGKITHYTIYAMELD-- 610
V + ++VP+ + ++ + +S+S+ L W PP NG IT YT+ +++
Sbjct: 905 EEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIP 964
Query: 611 -TNRAFQITTIDNSFLITGLKKYTKYKMRVAASTHVGESSLSEENDIFVRTSEDEPESSP 669
I D + +TGLK T Y ++V A T G S + RT + +
Sbjct: 965 LLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSP--SVQFRTLPVD-QVFA 1021
Query: 670 QDVEVIDVTADEIRLKWSPPEKPNGIIIAYEVLYKNIDTLYMKNTSTTDIILRNLRPHTL 729
++ V V + L W PE N + +++LY + + + T ++ NL+P
Sbjct: 1022 KNFHVKAVMKTSVLLSWEIPENYNS-AMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKS 1080
Query: 730 YNISVRSYTRFGHGNQVSSLLSVRTSETVPD---SAPENITYKNISSGEIELSFLPPSSP 786
Y S+ GN L T++T PD + P I N+ G I + LP
Sbjct: 1081 Y-----SFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNL-DGMITVQ-LPEVPA 1133
Query: 787 NGIIQKYTIY---LKRSNG 802
N I+ Y I LK+S G
Sbjct: 1134 NENIKGYYIIIVPLKKSRG 1152
Score = 131 bits (330), Expect = 7e-30
Identities = 133/535 (24%), Positives = 218/535 (40%), Gaps = 61/535 (11%)
Query: 1245 PPQNLTLINCTSDFVWLKW---SPSPLPGGIVKVYSFKIHEHETDTIYYKNISGFKTEA- 1300
PP + T+ + L W +P P+ I++ H+ + YK I G T
Sbjct: 325 PPGTPVVTESTATSITLTWDSGNPEPVSYYIIQ------HKPKNSEELYKEIDGVATTRY 378
Query: 1301 KLVGLEPVSTYSIRVSAFTKVGNGNQFSNVVKFTTQESVPDVVQNMQCMATSWQSVLVKW 1360
+ GL P S Y RV A +G G V+ T++++ +++Q S ++LV+W
Sbjct: 379 SVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQW 438
Query: 1361 DPPKKANGIITQYMVTVERNST-------KVSPQDHMYTFI-KLLANTSYVFKVRASTSA 1412
P++ NG I Y V + T K + D T I L+ +Y KV A TS
Sbjct: 439 KEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSI 498
Query: 1413 GEGDESTCHVSTLPET-VPSVPTNIAFSDVQSTSATLTWIRP--DTILGYFQNYKITTQL 1469
G+G S+ + + +T VP P N TS L+W P DTI Y YK
Sbjct: 499 GDGPLSS-DIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANYELVYKDG--- 554
Query: 1470 RAQKCKEWESEECVEYQKIQYLYEAHLTEETVYGLKKFRWYRFQVAASTNAGYGNASNWI 1529
E+ + Q + T + GLK Y F++AA + G G ++ I
Sbjct: 555 --------------EHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEI 600
Query: 1530 STKTLPGPPDGPPENVHVVATSPFSISISWSEP------AVITGPTCYLIDVKSVDNDEF 1583
S +T+ P PP+++ + S SI +SW P +IT + V D+
Sbjct: 601 SARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPH 660
Query: 1584 NISFIKSNEENKTIEIKDLEIFTRYSVVITAFTGNISAAYVEGKSSAEMIVTTLESAPKD 1643
I I S+ +E LE +T Y + +TA T G S +++ T E P
Sbjct: 661 EILGIPSDTTKYLLE--QLEKWTEYRITVTAHTD-----VGPGPESLSVLIRTNEDVPSG 713
Query: 1644 PPNNMTFQKIPDEVTKFQLTFLPPSQPNGNIQVYQALVYREDDPTA--------VQIHNL 1695
PP + + + K P++ +G I+ YQ R ++ V + +
Sbjct: 714 PPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADA 773
Query: 1696 SIIQKTNTFVIAMLEGLKGGHTYNISVYAVNSAGAGPK-VPMRITMDIKAPARPK 1749
T ++ GL+ +Y+++V A + G G + P ++ P +P+
Sbjct: 774 QWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGKPR 828
Score = 120 bits (301), Expect = 2e-26
Identities = 182/725 (25%), Positives = 269/725 (37%), Gaps = 107/725 (14%)
Query: 1066 SSTAINVSWVPPAQPNGLVFYYVSLILQQTPRHVRP------PLVTYERSIYFDNLEKYT 1119
++T+I ++W P + +Y I+Q P++ + T S+ L Y+
Sbjct: 335 TATSITLTW-DSGNPEPVSYY----IIQHKPKNSEELYKEIDGVATTRYSVA--GLSPYS 387
Query: 1120 DYILKITPSTEKGFSDTYTAQLYIKTEEDVPETSPIINTFKNLSSTSVLLSWDPPVKPNG 1179
DY ++ G + + +T E P ++P + LSST++L+ W P +PNG
Sbjct: 388 DYEFRVVAVNNIGRGPP-SEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNG 446
Query: 1180 AIISY------DLTLQGPNENYSFITSDNYIILEELSPFTLYSFFAAARTRKGLGP-SSI 1232
I Y D T N + + L P YS A T G GP SS
Sbjct: 447 QIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSD 506
Query: 1233 LFFYTDESVPLAPPQNLTLINCTSDFVWLKWSP--SPLPGGIVKVYSFKIHEHETDTIYY 1290
+ T VP P N + + L W+P S VY H E
Sbjct: 507 IQVITQTGVP-GQPLNFKAEPESETSILLSWTPPRSDTIANYELVYKDGEHGEEQRITIE 565
Query: 1291 KNISGFKTEAKLVGLEPVSTYSIRVSAFTKVGNGNQFSNVVKFTTQESVPDVVQNMQCMA 1350
T +L GL+P S Y R++A + G G + + T Q Q++ C +
Sbjct: 566 PG-----TSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTS 620
Query: 1351 TSWQSVLVKWDPP--KKANGIITQYMV---TVERNSTK------VSPQDHMYTFIKLLAN 1399
S S+LV W PP +K NGIIT+Y + V+ K + Y +L
Sbjct: 621 PSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKW 680
Query: 1400 TSYVFKVRASTSAGEGDESTCHVSTLPETVPS-VPTNIAFSDVQSTSATLTWIRP----- 1453
T Y V A T G G ES + E VPS P + V STS ++W P
Sbjct: 681 TEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQ 740
Query: 1454 -DTILGYFQNY--------KITTQLRAQKCKE--WESEECVEYQKIQYLYEAHLTEETVY 1502
I GY +Y K L+ + WE ++ E+ I +
Sbjct: 741 HGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMI------------IS 788
Query: 1503 GLKKFRWYRFQVAASTNAGYGNASNWISTKTLPGPPDGPPENVHVVATSPFSISISWSEP 1562
GL+ Y V A T G G S T P P + + T + I W P
Sbjct: 789 GLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGKP--RLVINHTQMNTALIQWHPP 846
Query: 1563 AVITGPTCYLIDVKSVDNDEFNISF-IKSNEENKTIEIKDLEIFTRYSVVITAFTGNISA 1621
GP + + F K E T+E + E TA + A
Sbjct: 847 VDTFGPL-----------QGYRLKFGRKDMEPLTTLEFSEKEDH------FTATDIHKGA 889
Query: 1622 AYVEGKSSAEMI---------VTTLESAPKDPPNNMTFQKIPDEVTKFQLTFLPP--SQP 1670
+YV S+ + ++ E P P N+ + T QL++ PP ++
Sbjct: 890 SYVFRLSARNKVGFGEEMVKEISIPEEVPTGFPQNLHSEGTTS--TSVQLSWQPPVLAER 947
Query: 1671 NGNIQVYQALVYREDDPTAVQIHNLSIIQKTNTFVIAMLEGLKGGHTYNISVYAVNSAGA 1730
NG I Y L+YR+ + + + L + T L GLK TY++ V A S G
Sbjct: 948 NGIITKY-TLLYRDINIPLLPMEQLIVPADTTM----TLTGLKPDTTYDVKVRAHTSKGP 1002
Query: 1731 GPKVP 1735
GP P
Sbjct: 1003 GPYSP 1007
Score = 53.9 bits (128), Expect = 2e-06
Identities = 103/456 (22%), Positives = 178/456 (39%), Gaps = 78/456 (17%)
Query: 9 LLFIGTSETQVDVSNVVPGTRYDITISSISTTYTSP--VTRIVTTNVTKP-GPPVFLAGE 65
+L I + T+ + + T Y IT+++ + P ++ ++ TN P GPP + E
Sbjct: 662 ILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVE 721
Query: 66 RVGSAGILLSWNTP-PNP-NGRIISYIVKYKEVC---PWMQTVYTQVRSKPDSLE----- 115
V S + +SW +P PN +G+I Y V Y + P Q + V E
Sbjct: 722 AVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDTT 781
Query: 116 ---VLLTNLNPGTTYEIKVAAENSAGIGVFSDPFLFQTAESAPGKVVNLTVEAYNASAVK 172
++++ L P T+Y + V A + G G S P L T + PGK L + +
Sbjct: 782 EHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGK-PRLVINHTQMNTAL 840
Query: 173 LIWYLP---------------RQPNGKITSFKISVKH-------------------ARSG 198
+ W+ P R+ +T+ + S K AR+
Sbjct: 841 IQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNK 900
Query: 199 I-----VVKDVSIRVEDILTGKLPECNENSESFLWSTASPSPTLGRVTPPSRTTH---SS 250
+ +VK++SI E++ TG P+ N +SE T S S L P + +
Sbjct: 901 VGFGEEMVKEISI-PEEVPTG-FPQ-NLHSE----GTTSTSVQLSWQPPVLAERNGIITK 953
Query: 251 STLTQNEIS--------SVWKEPISFVVTHLRPYTTYLFEVSAATTE--AGYIDSTIVRT 300
TL +I+ + + +T L+P TTY +V A T++ Y S RT
Sbjct: 954 YTLLYRDINIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRT 1013
Query: 301 PESVPEGPPQNCVTGNITGKSFSILWDPPTIVTGKFSYRVELYGPSGRILDNSTKDLKFA 360
V + +N + S + W+ P +++ LY + + + +
Sbjct: 1014 -LPVDQVFAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKI-LYDDGKMVEEVDGRATQKL 1071
Query: 361 FTNLTPFTMYDVYIAAETSAGTGPKSNISVFTPPDV 396
NL P Y + ++ G + ++ T PDV
Sbjct: 1072 IVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDV 1107
>gi|18860890 protein tyrosine phosphatase, receptor type, D isoform 2
precursor [Homo sapiens]
Length = 1899
Score = 248 bits (634), Expect = 4e-65
Identities = 155/446 (34%), Positives = 240/446 (53%), Gaps = 25/446 (5%)
Query: 1861 NGPLKPKKQYLFKFRATNIMGQ---FTDSDYSDPVKTLGEGLSERTVEI-----ILSVTL 1912
N L+ ++Y+F A + + S YSDPV ++ T E ++ L
Sbjct: 1203 NKQLQSGQEYVFFVLAVMEHAESKMYATSPYSDPVVSMDLDPQPITDEEEGLIWVVGPVL 1262
Query: 1913 CILSIILLGTAIFAFARIRQKQKEGGTYSPQDAEIIDTKLKLDQLITVADLELKDERLTR 1972
++ II + AI + R R + + P + EI +EL+ RL
Sbjct: 1263 AVVFIICIVIAILLYKRKRAESDSRKSSIPNNKEIPSHH-------PTDPVELR--RLNF 1313
Query: 1973 LLSYRKSIKPISKKSFLQHVEELCTNNNLKFQEEFSELPKFLQDLSSTDADLPWNRAKNR 2032
S PI H+E L N+NLKF +E+ + Q + ++L N+ KNR
Sbjct: 1314 QTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPG-QQFTWEHSNLEVNKPKNR 1372
Query: 2033 FPNIKPYNNNRVKLIADASVPGSDYINASYISGYLCPNEFIATQGPLPGTVGDFWRMVWE 2092
+ N+ Y+++RV L A +PGSDY+NA+YI GY N +IATQG LP T GDFWRM+WE
Sbjct: 1373 YANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWE 1432
Query: 2093 TRAKTLVMLTQCFEKGRIRCHQYWPEDNKPVTVFGDIVITKLMEDVQI-DWTIRDLKIER 2151
R+ T+VM+T+ E+ R++C QYWP ++ G + +T L++ V++ + +R + +
Sbjct: 1433 QRSATVVMMTKLEERSRVKCDQYWP--SRGTETHGLVQVT-LLDTVELATYCVRTFALYK 1489
Query: 2152 HG--DCMTVRQCNFTAWPEHGVPENSAPLIHFVKLVRASRAHDTTPMIVHCSAGVGRTGV 2209
+G + VRQ FTAWP+HGVPE+ P + F++ V+ D PM+VHCSAGVGRTG
Sbjct: 1490 NGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGC 1549
Query: 2210 FIALDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLLSNKGSNQPI 2269
FI +D + + I VDIYG V +R++R MVQ QYIF+H +L+ ++ + P
Sbjct: 1550 FIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPA 1609
Query: 2270 CFVNYSALQKMDSLDAMEGDVELEWE 2295
+ Y+ +QK+ ++ E +E E
Sbjct: 1610 RNL-YAYIQKLTQIETGENVTGMELE 1634
Score = 223 bits (567), Expect = 2e-57
Identities = 225/839 (26%), Positives = 363/839 (43%), Gaps = 71/839 (8%)
Query: 581 SSSSILLYWDP--PEYPNGKITHYTIYAMELDTNRAFQIT--TIDNSFLITGLKKYTKYK 636
+++SI L WD PE +++Y I ++ ++ + + GL Y+ Y+
Sbjct: 322 TATSITLTWDSGNPE----PVSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYE 377
Query: 637 MRVAASTHVGESSLSEENDIFVRTSEDEPESSPQDVEVIDVTADEIRLKWSPPEKPNGII 696
RV A ++G SE + +TSE P S+P+DV+ +++ I ++W PE+PNG I
Sbjct: 378 FRVVAVNNIGRGPPSEP--VLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQI 435
Query: 697 IAYEVLYKNIDTLYMKNTSTTDII------LRNLRPHTLYNISVRSYTRFGHGNQVSSLL 750
Y V Y T ++ N ++ + NL P Y++ V ++T G G +SS +
Sbjct: 436 QGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDG-PLSSDI 494
Query: 751 SVRTSETVPDSAPENITYKNISSGEIELSFLPPSSPNGIIQKYTIYLKRSNGNEERTINT 810
V T VP P N + S I LS+ PP S I +Y +G E+R
Sbjct: 495 QVITQTGVPGQ-PLNFKAEPESETSILLSWTPPRSDT-IANYELVYKDGEHGEEQRITIE 552
Query: 811 TSLTQNIKVLKKYTQYIIEVSASTLKGEGVRSAPISILTEEDAPDSPPQDFSVKQLSGVT 870
+ ++ LK + Y ++A + +G G +A IS T + P +PPQD S S +
Sbjct: 553 PGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTS 612
Query: 871 VKLSWQPP--LEPNGIILYYTVYVW-------NRSSLKTINVTETSLELSDLDYNVEYSA 921
+ +SWQPP + NGII Y++ + I T L L+ EY
Sbjct: 613 ILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRI 672
Query: 922 YVTASTRFGDGKTRSNIISFQTPEGAPSDPPKDVYYANLSSSSIILFWTP--PSKPNGII 979
VTA T G G +++ +T E PS PP+ V ++S+S+ + W P+K +G I
Sbjct: 673 TVTAHTDVGPGPESLSVL-IRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQI 731
Query: 980 QYYSVYY-RNTSG-----TFMQNFTLHEVTNDFDNMTV-STIIDKLTIFSYYTFWLTAST 1032
+ Y V+Y R +G +++ L + +FD+ T II L + Y+ +TA T
Sbjct: 732 RGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYT 791
Query: 1033 SVGNGNKSSDIIEVYTDQDIPEGFVGNLTYESISSTAINVSWVPPAQPNGLVFYYVSLIL 1092
+ G+G +S + V T +P G + + +TA+ + W PP G + Y
Sbjct: 792 TKGDGARSKPKL-VSTTGAVP-GKPRLVINHTQMNTAL-IQWHPPVDTFGPLQGY----R 844
Query: 1093 QQTPRHVRPPLVTYERSIYFD-----NLEKYTDYILKITPSTEKGFSDTYTAQLYIKTEE 1147
+ R PL T E S D ++ K Y+ +++ + GF + ++ I E
Sbjct: 845 LKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEEMVKEISI--PE 902
Query: 1148 DVPETSPIINTFKNLSSTSVLLSWDPPV--KPNGAIISYDLTLQGPN-----ENYSFITS 1200
+VP P + +STSV LSW PPV + NG I Y L + N + +
Sbjct: 903 EVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPA 962
Query: 1201 DNYIILEELSPFTLYSFFAAARTRKGLGPSSILFFYTDESVPLAPPQNLTLINCTSDFVW 1260
D + L L P T Y A T KG GP S + V +N + V
Sbjct: 963 DTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVFAKNFHVKAVMKTSVL 1022
Query: 1261 LKWSPSPLPGGIVKVYSFKIHEHETDTIYYKNISGFKTEAKLVGLEPVSTYSIRVSAFTK 1320
L W +P FKI + + + + G T+ +V L+P +YS F
Sbjct: 1023 LSWE---IPENYNSAMPFKILYDDGKMV--EEVDGRATQKLIVNLKPEKSYS-----FVL 1072
Query: 1321 VGNGNQFSNVVKFTTQESVPDVVQNMQCM--ATSWQSVLVKWDPPKKANGIITQYMVTV 1377
GN + T ++ PDV++ T+ ++ P AN I Y + +
Sbjct: 1073 TNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPANENIKGYYIII 1131
Score = 214 bits (544), Expect = 1e-54
Identities = 201/711 (28%), Positives = 328/711 (46%), Gaps = 89/711 (12%)
Query: 531 YVIRRLVPFTEHMISVSAFTIMGEGPPTV-LSVRTRQQVPSSI-KIINYKNISSSSILLY 588
Y + L P++++ V A +G GPP+ + +T +Q PSS + + + +SS++IL+
Sbjct: 365 YSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQ 424
Query: 589 WDPPEYPNGKITHYTIYAMELDTNRA----------FQITTIDNSFLITGLKKYTKYKMR 638
W PE PNG+I Y +Y T QITTI N L Y ++
Sbjct: 425 WKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGN------LVPQKTYSVK 478
Query: 639 VAASTHVGESSLSEENDIFVRTSEDEPESSPQDVEVIDVTADEIRLKWSPPEKPNGIIIA 698
V A T +G+ LS +DI V T P P + + + I L W+PP + I
Sbjct: 479 VLAFTSIGDGPLS--SDIQVITQTGVP-GQPLNFKAEPESETSILLSWTPPR--SDTIAN 533
Query: 699 YEVLYKNIDTLYMKNTST---TDIILRNLRPHTLYNISVRSYTRFGHGNQVSSLLSVRTS 755
YE++YK+ + + + T L+ L+P++LY + + + G G + +S RT
Sbjct: 534 YELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAE-ISARTM 592
Query: 756 ETVPDSAPENITYKNISSGEIELSFLPP--SSPNGIIQKYTIYLKRSNGNEERT-----I 808
++ P + P++I+ + SS I +S+ PP NGII +Y+I +G +++ I
Sbjct: 593 QSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGI 652
Query: 809 NTTSLTQNIKVLKKYTQYIIEVSASTLKGEGVRSAPISILTEEDAPDSPPQDFSVKQLSG 868
+ + ++ L+K+T+Y I V+A T G G S + I T ED P PP+ V+ ++
Sbjct: 653 PSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNS 712
Query: 869 VTVKLSWQPPL--EPNGIILYYTVYVWNRSS--------LKTI----------NVTETSL 908
+VK+SW+ P+ + +G I Y V+ + LK + + TE +
Sbjct: 713 TSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDM 772
Query: 909 ELSDLDYNVEYSAYVTASTRFGDGKTRSNIISFQTPEGAPSDPPKDVYYANLSSSSIILF 968
+S L YS VTA T GDG RS T P P + + ++++ ++
Sbjct: 773 IISGLQPETSYSLTVTAYTTKGDG-ARSKPKLVSTTGAVPGKPRLVINHTQMNTA--LIQ 829
Query: 969 WTPPSKPNGIIQYYSVYYRNTSGTFMQNFTLHEVTNDFDNMTVSTIIDKLTIFSYYTFWL 1028
W PP G +Q Y + + M+ T E + D+ T + I + Y F L
Sbjct: 830 WHPPVDTFGPLQGYRLKFGRKD---MEPLTTLEFSEKEDHFTATDIHKGAS----YVFRL 882
Query: 1029 TASTSVGNGNKSSDIIEVYTDQDIPEGFVGNLTYESISSTAINVSWVPP--AQPNGLVFY 1086
+A VG G + + E+ +++P GF NL E +ST++ +SW PP A+ NG++
Sbjct: 883 SARNKVGFGEEM--VKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITK 940
Query: 1087 YVSLILQQTPRHVRPPLVTYERSIY-------FDNLEKYTDYILKITPSTEKGFSDTYTA 1139
Y L R + PL+ E+ I L+ T Y +K+ T KG Y+
Sbjct: 941 YTLLY-----RDINIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKG-PGPYSP 994
Query: 1140 QLYIKTEEDVPETSPIINTF--KNLSSTSVLLSWDPPVKPNGAI---ISYD 1185
+ +T +P F K + TSVLLSW+ P N A+ I YD
Sbjct: 995 SVQFRT---LPVDQVFAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYD 1042
Score = 193 bits (490), Expect = 2e-48
Identities = 114/282 (40%), Positives = 155/282 (54%), Gaps = 8/282 (2%)
Query: 1987 SFLQHVEELCTNNNLKFQE-EFSELPKFLQDLSS-TDADLPWNRAKNRFPNIKPYNNNRV 2044
+++Q + ++ T N+ E EF L S A+LP N+ KNR NI PY + RV
Sbjct: 1614 AYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRV 1673
Query: 2045 KLIADASVPGSDYINASYISGYLCPNEFIATQGPLPGTVGDFWRMVWETRAKTLVMLTQC 2104
L V GSDYINAS+I GY +IATQGPL T DFWRM+WE + +VMLT+
Sbjct: 1674 CLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKL 1733
Query: 2105 FEKGRIRCHQYWPEDNKPVTVFGDIVITKLMEDVQIDWTIRDLKI--ERHGDCMTVRQCN 2162
E GR +CHQYWP + + V+ + E + +R+ K+ R G TVRQ
Sbjct: 1734 REMGREKCHQYWPAERS--ARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQ 1791
Query: 2163 FTAWPEHGVPENSAPLIHFVKLVRASRAH--DTTPMIVHCSAGVGRTGVFIALDHLTQHI 2220
FT WPE GVP++ I F+ V ++ P+ VHCSAGVGRTGVFI L + + +
Sbjct: 1792 FTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERM 1851
Query: 2221 NDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLLSN 2262
VDI+ V LR++R MVQ QY F ++ L+ L +
Sbjct: 1852 RYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGS 1893
Score = 192 bits (487), Expect = 4e-48
Identities = 228/857 (26%), Positives = 372/857 (43%), Gaps = 86/857 (10%)
Query: 750 LSVRTSETVPDSAPENITYKNISSGEIELSFLPPSSPNGIIQKYTIYLKRSNGNEERTIN 809
L VR P + ++ + G + ++ + SP + K+ + + ++ I
Sbjct: 214 LYVRVRRVPPRFSIPPTNHEIMPGGSVNITCVAVGSPMPYV-KWMLGAEDLTPEDDMPIG 272
Query: 810 TTSLTQN-IKVLKKYTQYIIEVSASTLKGEGVRSAPISILTEEDAPDSPPQDFSVKQLSG 868
L N ++ YT V+ STL GV A I+ +T + P PP V + +
Sbjct: 273 RNVLELNDVRQSANYTC----VAMSTL---GVIEA-IAQITVKALP-KPPGTPVVTESTA 323
Query: 869 VTVKLSWQPPL-EPNGIILYYTVYVWNRSS---LKTIN-VTETSLELSDLDYNVEYSAYV 923
++ L+W EP + YY + ++S K I+ V T ++ L +Y V
Sbjct: 324 TSITLTWDSGNPEP---VSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRV 380
Query: 924 TASTRFGDGKTRSNIISFQTPEGAPSDPPKDVYYANLSSSSIILFWTPPSKPNGIIQYYS 983
A G G +++ QT E APS P+DV LSS++I++ W P +PNG IQ Y
Sbjct: 381 VAVNNIGRGPPSEPVLT-QTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYR 439
Query: 984 VYYRNTSGTFMQNFTLHEVTNDFDNMTVSTIIDKLTIFSYYTFWLTASTSVGNGNKSSDI 1043
VYY + N+ H V D T+ ++ + T Y+ + A TS+G+G SSDI
Sbjct: 440 VYYTMDPTQHVNNWMKHNVA-DSQITTIGNLVPQKT----YSVKVLAFTSIGDGPLSSDI 494
Query: 1044 IEVYTDQDIPEGFVGNLTYESISSTAINVSWVPPAQPNGLVFYYVSLILQQTPRHVRPPL 1103
+V T +P G N E S T+I +SW PP + + + Y ++ + H
Sbjct: 495 -QVITQTGVP-GQPLNFKAEPESETSILLSWTPP-RSDTIANYE---LVYKDGEHGEEQR 548
Query: 1104 VTYE--RSIYFDNLEKYTDYILKITPSTEKGFSDTYTAQLYIKTEEDVPETSPIINTFKN 1161
+T E S L+ + Y ++ + +G + TA++ +T + P P + +
Sbjct: 549 ITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGAS-TAEISARTMQSKPSAPPQDISCTS 607
Query: 1162 LSSTSVLLSWDPPV--KPNGAIISYDLTLQG-------PNENYSFITSDNYIILEELSPF 1212
SSTS+L+SW PP K NG I Y + P+E + +LE+L +
Sbjct: 608 PSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKW 667
Query: 1213 TLYSFFAAARTRKGLGPSSI-LFFYTDESVPLAPPQNLTLINCTSDFVWLKWSPSPLPGG 1271
T Y A T G GP S+ + T+E VP PP+ + + S V + W SP+P
Sbjct: 668 TEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWR-SPVPNK 726
Query: 1272 IV-KVYSFKIHEHETDTIYYKNISGFK--------------TEAKLV--GLEPVSTYSIR 1314
++ +++H + K K TE ++ GL+P ++YS+
Sbjct: 727 QHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLT 786
Query: 1315 VSAFTKVGNGNQFSNVVKFTTQE--SVPDVVQNMQCMATSWQSVLVKWDPPKKANGIITQ 1372
V+A+T G+G + + TT P +V N M T+ L++W PP G +
Sbjct: 787 VTAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNTA----LIQWHPPVDTFGPLQG 842
Query: 1373 YMVTVERN------STKVSPQDHMYTFIKLLANTSYVFKVRASTSAGEGDESTCHVSTLP 1426
Y + R + + S ++ +T + SYVF++ A G G+E +S +P
Sbjct: 843 YRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEEMVKEIS-IP 901
Query: 1427 ETVPS-VPTNIAFSDVQSTSATLTWIRPDTILGYFQNYKITTQLRAQKCKEWESEECVEY 1485
E VP+ P N+ STS L+W P +L +N IT + + +
Sbjct: 902 EEVPTGFPQNLHSEGTTSTSVQLSWQPP--VLAE-RNGIITKYTLLYR------DINIPL 952
Query: 1486 QKIQYLYEAHLTEETVYGLKKFRWYRFQVAASTNAGYGNASNWISTKTLPGPPDGPPENV 1545
++ L T T+ GLK Y +V A T+ G G S + +TLP +N
Sbjct: 953 LPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLP-VDQVFAKNF 1011
Query: 1546 HVVATSPFSISISWSEP 1562
HV A S+ +SW P
Sbjct: 1012 HVKAVMKTSVLLSWEIP 1028
Score = 183 bits (464), Expect = 2e-45
Identities = 213/798 (26%), Positives = 326/798 (40%), Gaps = 95/798 (11%)
Query: 790 IQKYTIYLKRSNGNE-ERTINTTSLTQ-NIKVLKKYTQYIIEVSASTLKGEGVRSAPISI 847
+ Y I K N E + I+ + T+ ++ L Y+ Y V A G G S P+
Sbjct: 338 VSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLT 397
Query: 848 LTEEDAPDSPPQDFSVKQLSGVTVKLSWQPPLEPNGIILYYTVYV----------WNRSS 897
T E AP S P+D + LS T+ + W+ P EPNG I Y VY W + +
Sbjct: 398 QTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHN 457
Query: 898 LKTINVTETSLELSDLDYNVEYSAYVTASTRFGDGKTRSNIISFQTPEGAPSDPPKDVYY 957
+ +T + +L YS V A T GDG S+ I T G P P +
Sbjct: 458 VADSQIT----TIGNLVPQKTYSVKVLAFTSIGDGPLSSD-IQVITQTGVPGQ-PLNFKA 511
Query: 958 ANLSSSSIILFWTPPSKPNGIIQYYSVYYRNTSGTFMQNFTLHEVTNDFDNMTVSTIIDK 1017
S +SI+L WTPP + I Y + Y++ Q T+ T S +
Sbjct: 512 EPESETSILLSWTPPR--SDTIANYELVYKDGEHGEEQRITIEPGT--------SYRLQG 561
Query: 1018 LTIFSYYTFWLTASTSVGNGNKSSDIIEVYTDQDIPEGFVGNLTYESISSTAINVSWVPP 1077
L S Y F L A + G G +++ I T Q P +++ S SST+I VSW PP
Sbjct: 562 LKPNSLYYFRLAARSPQGLGASTAE-ISARTMQSKPSAPPQDISCTSPSSTSILVSWQPP 620
Query: 1078 --AQPNGLV----FYYVSLILQQTPRHVRPPLVTYERSIYFDNLEKYTDYILKITPSTEK 1131
+ NG++ Y ++ + H + + + LEK+T+Y + +T T+
Sbjct: 621 PVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDV 680
Query: 1132 GFSDTYTAQLYIKTEEDVPETSPIINTFKNLSSTSVLLSWDPPV---------------- 1175
G + + I+T EDVP P + ++STSV +SW PV
Sbjct: 681 G-PGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYV 739
Query: 1176 -----KPNGAIISYDLTLQGPNENYSFITSDNYIILEELSPFTLYSFFAAARTRKGLGP- 1229
+P G + D+ L + T+++ +I+ L P T YS A T KG G
Sbjct: 740 RMENGEPKGQPMLKDVMLADAQWEFD-DTTEHDMIISGLQPETSYSLTVTAYTTKGDGAR 798
Query: 1230 SSILFFYTDESVPLAPPQNLTLINCTSDFVWLKWSPSPLPGGIVKVYSFKIHEHETDTIY 1289
S T +VP P L + + + ++W P G ++ Y K + + +
Sbjct: 799 SKPKLVSTTGAVPGKP--RLVINHTQMNTALIQWHPPVDTFGPLQGYRLKFGRKDMEPLT 856
Query: 1290 YKNISGFKTEAKLVGLEPVSTYSIRVSAFTKVGNGNQFSNVVKFTTQESVP-DVVQNMQC 1348
S + + ++Y R+SA KVG G + V + + E VP QN+
Sbjct: 857 TLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEEM--VKEISIPEEVPTGFPQNLHS 914
Query: 1349 MATSWQSVLVKWDPPKKA--NGIITQYM-------VTVERNSTKVSPQDHMYTFIKLLAN 1399
T+ SV + W PP A NGIIT+Y + + + P D T L +
Sbjct: 915 EGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPADTTMTLTGLKPD 974
Query: 1400 TSYVFKVRASTSAGEGDES-TCHVSTLPETVPSV-PTNIAFSDVQSTSATLTWIRPDTIL 1457
T+Y KVRA TS G G S + TLP V V N V TS L+W P
Sbjct: 975 TTYDVKVRAHTSKGPGPYSPSVQFRTLP--VDQVFAKNFHVKAVMKTSVLLSWEIP---- 1028
Query: 1458 GYFQNYKITTQLRAQKCKEWESEECVEYQKIQYLYEAHLTEETVYGLKKFRWYRFQVAAS 1517
+NY + ++ + VE + T++ + LK + Y F +
Sbjct: 1029 ---ENYNSAMPFKIL----YDDGKMVEE------VDGRATQKLIVNLKPEKSYSFVLTNR 1075
Query: 1518 TNAGYGNASNWISTKTLP 1535
N+ G + ++ KT P
Sbjct: 1076 GNSA-GGLQHRVTAKTAP 1092
Score = 178 bits (451), Expect = 6e-44
Identities = 198/771 (25%), Positives = 338/771 (43%), Gaps = 91/771 (11%)
Query: 286 ATTEAGYIDSTIVRTPESVPEGPPQNCVTGNITGKSFSILWDPPT-------IVTGKFSY 338
A + G I++ T +++P+ PP V T S ++ WD I+ K
Sbjct: 291 AMSTLGVIEAIAQITVKALPK-PPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKN 349
Query: 339 RVELYGPSGRILDNSTKDLKFAFTNLTPFTMYDVYIAAETSAGTGPKSN-ISVFTPPDVP 397
ELY + +++ L+P++ Y+ + A + G GP S + T P
Sbjct: 350 SEELYKEIDGVATT-----RYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAP 404
Query: 398 G-AVFDLQLAEVESTQVRITWKKPRQPNGIINQYRVKVLVPETGII---LENTLLTGNNE 453
A D+Q + ST + + WK+P +PNG I YRV + T + +++ +
Sbjct: 405 SSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQIT 464
Query: 454 YINDPMAPEIVNIVEPMVGLYEGSAEMSSDLHSLATFIYNSHPDKNFPARNRAEDQTSPV 513
I + + P+ V+ + G +SSD+ + P NF A E +TS +
Sbjct: 465 TIGN-LVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQP-LNFKA--EPESETSIL 520
Query: 514 VTTRNQYITDIAAEQL-------------------SYVIRRLVPFTEHMISVSAFTIMGE 554
++ IA +L SY ++ L P + + ++A + G
Sbjct: 521 LSWTPPRSDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGL 580
Query: 555 GPPTV-LSVRTRQQVPSS-IKIINYKNISSSSILLYWDPP--EYPNGKITHYTI--YAME 608
G T +S RT Q PS+ + I+ + SS+SIL+ W PP E NG IT Y+I A++
Sbjct: 581 GASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVD 640
Query: 609 LDTNRAFQITTIDN---SFLITGLKKYTKYKMRVAASTHVGESSLSEENDIFVRTSEDEP 665
+ ++ +I I + +L+ L+K+T+Y++ V A T VG E + +RT+ED P
Sbjct: 641 GEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPG--PESLSVLIRTNEDVP 698
Query: 666 ESSPQDVEVIDVTADEIRLKW-SP-PEKPNGIIIAYEVLYKNIDTLYMK----------- 712
P+ VEV V + +++ W SP P K +G I Y+V Y ++ K
Sbjct: 699 SGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLA 758
Query: 713 -------NTSTTDIILRNLRPHTLYNISVRSYTRFGHGNQVSSLLSVRTSETVPDSAPEN 765
+T+ D+I+ L+P T Y+++V +YT G G + L V T+ VP
Sbjct: 759 DAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKL-VSTTGAVPGKPRLV 817
Query: 766 ITYKNISSGEIELSFLPPSSPNGIIQKYTIYLKRSNGNEERTINTTSLTQNIKV--LKKY 823
I + +++ I+ + PP G +Q Y + R + T+ + + + K
Sbjct: 818 INHTQMNTALIQ--WHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKG 875
Query: 824 TQYIIEVSASTLKGEGVRSAPISILTEEDAPDSPPQDFSVKQLSGVTVKLSWQPPL--EP 881
Y+ +SA G G I E+ P PQ+ + + +V+LSWQPP+ E
Sbjct: 876 ASYVFRLSARNKVGFGEEMVK-EISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAER 934
Query: 882 NGIILYYTVYVWNRS-----SLKTINVTETSLELSDLDYNVEYSAYVTASTRFGDGKTRS 936
NGII YT+ + + + I +T++ L+ L + Y V A T G G S
Sbjct: 935 NGIITKYTLLYRDINIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPG-PYS 993
Query: 937 NIISFQTPEGAPSDP--PKDVYYANLSSSSIILFWTPPSKPNGIIQYYSVY 985
+ F+T P D K+ + + +S++L W P N + + +Y
Sbjct: 994 PSVQFRT---LPVDQVFAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILY 1041
Score = 153 bits (387), Expect = 2e-36
Identities = 181/763 (23%), Positives = 308/763 (40%), Gaps = 93/763 (12%)
Query: 908 LELSDLDYNVEYSAYVTASTRFGDGKTRSNIISFQTPEGAPSDPPKDVYYANLSSSSIIL 967
LEL+D+ + Y+ ++ + + + + P G P +++SI L
Sbjct: 276 LELNDVRQSANYTCVAMSTLGVIEAIAQITVKALPKPPGTP-------VVTESTATSITL 328
Query: 968 FWTPPSKPNGIIQYYSVYYRNTSGTFMQNFTLHEVTNDFDNM-TVSTIIDKLTIFSYYTF 1026
W + + YY + ++ + E+ + D + T + L+ +S Y F
Sbjct: 329 TWDSGNPEP--VSYYIIQHKPKNS--------EELYKEIDGVATTRYSVAGLSPYSDYEF 378
Query: 1027 WLTASTSVGNGNKSSDIIEVYTDQDIPEGFVGNLTYESISSTAINVSWVPPAQPNGLVFY 1086
+ A ++G G S ++ T + P ++ +SST I V W P +PNG +
Sbjct: 379 RVVAVNNIGRGPPSEPVL-TQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQG 437
Query: 1087 YVSLILQQTPRHVRPPL---VTYERSIYFDNLEKYTDYILKITPSTEKGFSDTYTAQLYI 1143
Y +HV + V + NL Y +K+ T G ++ + +
Sbjct: 438 YRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIG-DGPLSSDIQV 496
Query: 1144 KTEEDVPETSPIINTFKNLSSTSVLLSWDPPVKPNGAIISYDLTLQ----GPNENYSFIT 1199
T+ VP P+ + S TS+LLSW PP + I +Y+L + G + +
Sbjct: 497 ITQTGVPG-QPLNFKAEPESETSILLSWTPP--RSDTIANYELVYKDGEHGEEQRITIEP 553
Query: 1200 SDNYIILEELSPFTLYSFFAAARTRKGLGPSSI-LFFYTDESVPLAPPQNLTLINCTSDF 1258
+Y L+ L P +LY F AAR+ +GLG S+ + T +S P APPQ+++ + +S
Sbjct: 554 GTSYR-LQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTS 612
Query: 1259 VWLKWSPSPLP--GGIVKVYSFKIHEHETDTIYYKNISGFKTEAK---LVGLEPVSTYSI 1313
+ + W P P+ GI+ YS K + + I G ++ L LE + Y I
Sbjct: 613 ILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRI 672
Query: 1314 RVSAFTKVGNGNQFSNVVKFTTQESVPDVVQNMQCMATSWQSVLVKWDPP--KKANGIIT 1371
V+A T VG G + +V+ T ++ + ++ A + SV V W P K +G I
Sbjct: 673 TVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIR 732
Query: 1372 QYMV---TVERNSTKVSPQ-----------------DHMYTFIKLLANTSYVFKVRASTS 1411
Y V +E K P +H L TSY V A T+
Sbjct: 733 GYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTT 792
Query: 1412 AGEGDESTCHVSTLPETVPSVPTNIAFSDVQSTSATLTWIRPDTILGYFQNYKITTQLRA 1471
G+G S + + VP P + + Q +A + W P G Q Y++
Sbjct: 793 KGDGARSKPKLVSTTGAVPGKP-RLVINHTQMNTALIQWHPPVDTFGPLQGYRLKFGR-- 849
Query: 1472 QKCKEWESEECVEYQKIQYLYEAHLTEETVYGLKKFRWYRFQVAASTNAGYGNASNWIST 1531
K+ E +E+ + E H T ++ K Y F+++A G+G +
Sbjct: 850 ---KDMEPLTTLEFSE----KEDHFTATDIH---KGASYVFRLSARNKVGFGE--EMVKE 897
Query: 1532 KTLPGP-PDGPPENVHVVATSPFSISISWSEP------AVITGPTCYLIDVKSVDNDEFN 1584
++P P G P+N+H T+ S+ +SW P +IT T D+ N
Sbjct: 898 ISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDI--------N 949
Query: 1585 ISFIKSNE----ENKTIEIKDLEIFTRYSVVITAFTGNISAAY 1623
I + + + T+ + L+ T Y V + A T Y
Sbjct: 950 IPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPY 992
Score = 135 bits (340), Expect = 5e-31
Identities = 195/859 (22%), Positives = 324/859 (37%), Gaps = 147/859 (17%)
Query: 13 GTSETQVDVSNVVPGTRYDITISSISTTYTSPVTRIVTTNVTKPGP---PVFLAGERVGS 69
G + T+ V+ + P + Y+ + +++ P + V T ++ P P + + S
Sbjct: 359 GVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSS 418
Query: 70 AGILLSWNTPPNPNGRIISYIVKY-----KEVCPWMQTVYTQVRSKPDSLEVLLTNLNPG 124
IL+ W P PNG+I Y V Y + V WM+ + DS + NL P
Sbjct: 419 TTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMK------HNVADSQITTIGNLVPQ 472
Query: 125 TTYEIKVAAENSAGIGVFSDPFLFQTAESAPGKVVNLTVEAYNASAVKLIWYLPRQPNGK 184
TY +KV A S G G S T PG+ +N E + +++ L W PR +
Sbjct: 473 KTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPR--SDT 530
Query: 185 ITSFKISVKHARSGIVVKDVSIRVEDILTGKLPECNENSESFLWSTASPSPTLGRVTPPS 244
I ++++ K G ++ I +E + +L NS + A LG T
Sbjct: 531 IANYELVYKDGEHG---EEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTA-- 585
Query: 245 RTTHSSSTLTQNEISSVWKEPISFVVTHLRPYTTYLFEVSAATTEAGYIDSTIVRTPESV 304
E+SA T + S
Sbjct: 586 -------------------------------------EISARTMQ-------------SK 595
Query: 305 PEGPPQNCVTGNITGKSFSILWDPPTIVTGK---FSYRVELYGPSG------RILDNSTK 355
P PPQ+ + + S + W PP + Y ++ G IL +
Sbjct: 596 PSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSD 655
Query: 356 DLKFAFTNLTPFTMYDVYIAAETSAGTGPKS-NISVFTPPDVP-GAVFDLQLAEVESTQV 413
K+ L +T Y + + A T G GP+S ++ + T DVP G +++ V ST V
Sbjct: 656 TTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSV 715
Query: 414 RITWKK--PRQPNGIINQYRVKVLVPETG-----IILENTLL---------TGNNEYIND 457
+++W+ P + +G I Y+V + E G +L++ +L T ++ I
Sbjct: 716 KVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIIS 775
Query: 458 PMAPEIVNIVEPMVGLYEGSAEMSSDLHSLATFIYNSHPDK--NFPARNRAEDQTSPVVT 515
+ PE + +G S T P N N A Q P V
Sbjct: 776 GLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNTALIQWHPPVD 835
Query: 516 TRNQYITDIAAEQLSYVIRRLVPFT--------------------EHMISVSAFTIMGEG 555
T + +L + + + P T ++ +SA +G G
Sbjct: 836 T----FGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFG 891
Query: 556 PPTVLSVRTRQQVPSSI-KIINYKNISSSSILLYWDPPEYP--NGKITHYTIYAMELD-- 610
V + ++VP+ + ++ + +S+S+ L W PP NG IT YT+ +++
Sbjct: 892 EEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIP 951
Query: 611 -TNRAFQITTIDNSFLITGLKKYTKYKMRVAASTHVGESSLSEENDIFVRTSEDEPESSP 669
I D + +TGLK T Y ++V A T G S + RT + +
Sbjct: 952 LLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSP--SVQFRTLPVD-QVFA 1008
Query: 670 QDVEVIDVTADEIRLKWSPPEKPNGIIIAYEVLYKNIDTLYMKNTSTTDIILRNLRPHTL 729
++ V V + L W PE N + +++LY + + + T ++ NL+P
Sbjct: 1009 KNFHVKAVMKTSVLLSWEIPENYNS-AMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKS 1067
Query: 730 YNISVRSYTRFGHGNQVSSLLSVRTSETVPD---SAPENITYKNISSGEIELSFLPPSSP 786
Y S+ GN L T++T PD + P I N+ G I + LP
Sbjct: 1068 Y-----SFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNL-DGMITVQ-LPEVPA 1120
Query: 787 NGIIQKYTIY---LKRSNG 802
N I+ Y I LK+S G
Sbjct: 1121 NENIKGYYIIIVPLKKSRG 1139
Score = 131 bits (330), Expect = 7e-30
Identities = 133/535 (24%), Positives = 218/535 (40%), Gaps = 61/535 (11%)
Query: 1245 PPQNLTLINCTSDFVWLKW---SPSPLPGGIVKVYSFKIHEHETDTIYYKNISGFKTEA- 1300
PP + T+ + L W +P P+ I++ H+ + YK I G T
Sbjct: 312 PPGTPVVTESTATSITLTWDSGNPEPVSYYIIQ------HKPKNSEELYKEIDGVATTRY 365
Query: 1301 KLVGLEPVSTYSIRVSAFTKVGNGNQFSNVVKFTTQESVPDVVQNMQCMATSWQSVLVKW 1360
+ GL P S Y RV A +G G V+ T++++ +++Q S ++LV+W
Sbjct: 366 SVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQW 425
Query: 1361 DPPKKANGIITQYMVTVERNST-------KVSPQDHMYTFI-KLLANTSYVFKVRASTSA 1412
P++ NG I Y V + T K + D T I L+ +Y KV A TS
Sbjct: 426 KEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSI 485
Query: 1413 GEGDESTCHVSTLPET-VPSVPTNIAFSDVQSTSATLTWIRP--DTILGYFQNYKITTQL 1469
G+G S+ + + +T VP P N TS L+W P DTI Y YK
Sbjct: 486 GDGPLSS-DIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANYELVYKDG--- 541
Query: 1470 RAQKCKEWESEECVEYQKIQYLYEAHLTEETVYGLKKFRWYRFQVAASTNAGYGNASNWI 1529
E+ + Q + T + GLK Y F++AA + G G ++ I
Sbjct: 542 --------------EHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEI 587
Query: 1530 STKTLPGPPDGPPENVHVVATSPFSISISWSEP------AVITGPTCYLIDVKSVDNDEF 1583
S +T+ P PP+++ + S SI +SW P +IT + V D+
Sbjct: 588 SARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPH 647
Query: 1584 NISFIKSNEENKTIEIKDLEIFTRYSVVITAFTGNISAAYVEGKSSAEMIVTTLESAPKD 1643
I I S+ +E LE +T Y + +TA T G S +++ T E P
Sbjct: 648 EILGIPSDTTKYLLE--QLEKWTEYRITVTAHTD-----VGPGPESLSVLIRTNEDVPSG 700
Query: 1644 PPNNMTFQKIPDEVTKFQLTFLPPSQPNGNIQVYQALVYREDDPTA--------VQIHNL 1695
PP + + + K P++ +G I+ YQ R ++ V + +
Sbjct: 701 PPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADA 760
Query: 1696 SIIQKTNTFVIAMLEGLKGGHTYNISVYAVNSAGAGPK-VPMRITMDIKAPARPK 1749
T ++ GL+ +Y+++V A + G G + P ++ P +P+
Sbjct: 761 QWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGKPR 815
Score = 120 bits (301), Expect = 2e-26
Identities = 182/725 (25%), Positives = 269/725 (37%), Gaps = 107/725 (14%)
Query: 1066 SSTAINVSWVPPAQPNGLVFYYVSLILQQTPRHVRP------PLVTYERSIYFDNLEKYT 1119
++T+I ++W P + +Y I+Q P++ + T S+ L Y+
Sbjct: 322 TATSITLTW-DSGNPEPVSYY----IIQHKPKNSEELYKEIDGVATTRYSVA--GLSPYS 374
Query: 1120 DYILKITPSTEKGFSDTYTAQLYIKTEEDVPETSPIINTFKNLSSTSVLLSWDPPVKPNG 1179
DY ++ G + + +T E P ++P + LSST++L+ W P +PNG
Sbjct: 375 DYEFRVVAVNNIGRGPP-SEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNG 433
Query: 1180 AIISY------DLTLQGPNENYSFITSDNYIILEELSPFTLYSFFAAARTRKGLGP-SSI 1232
I Y D T N + + L P YS A T G GP SS
Sbjct: 434 QIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSD 493
Query: 1233 LFFYTDESVPLAPPQNLTLINCTSDFVWLKWSP--SPLPGGIVKVYSFKIHEHETDTIYY 1290
+ T VP P N + + L W+P S VY H E
Sbjct: 494 IQVITQTGVP-GQPLNFKAEPESETSILLSWTPPRSDTIANYELVYKDGEHGEEQRITIE 552
Query: 1291 KNISGFKTEAKLVGLEPVSTYSIRVSAFTKVGNGNQFSNVVKFTTQESVPDVVQNMQCMA 1350
T +L GL+P S Y R++A + G G + + T Q Q++ C +
Sbjct: 553 PG-----TSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTS 607
Query: 1351 TSWQSVLVKWDPP--KKANGIITQYMV---TVERNSTK------VSPQDHMYTFIKLLAN 1399
S S+LV W PP +K NGIIT+Y + V+ K + Y +L
Sbjct: 608 PSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKW 667
Query: 1400 TSYVFKVRASTSAGEGDESTCHVSTLPETVPS-VPTNIAFSDVQSTSATLTWIRP----- 1453
T Y V A T G G ES + E VPS P + V STS ++W P
Sbjct: 668 TEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQ 727
Query: 1454 -DTILGYFQNY--------KITTQLRAQKCKE--WESEECVEYQKIQYLYEAHLTEETVY 1502
I GY +Y K L+ + WE ++ E+ I +
Sbjct: 728 HGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMI------------IS 775
Query: 1503 GLKKFRWYRFQVAASTNAGYGNASNWISTKTLPGPPDGPPENVHVVATSPFSISISWSEP 1562
GL+ Y V A T G G S T P P + + T + I W P
Sbjct: 776 GLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGKP--RLVINHTQMNTALIQWHPP 833
Query: 1563 AVITGPTCYLIDVKSVDNDEFNISF-IKSNEENKTIEIKDLEIFTRYSVVITAFTGNISA 1621
GP + + F K E T+E + E TA + A
Sbjct: 834 VDTFGPL-----------QGYRLKFGRKDMEPLTTLEFSEKEDH------FTATDIHKGA 876
Query: 1622 AYVEGKSSAEMI---------VTTLESAPKDPPNNMTFQKIPDEVTKFQLTFLPP--SQP 1670
+YV S+ + ++ E P P N+ + T QL++ PP ++
Sbjct: 877 SYVFRLSARNKVGFGEEMVKEISIPEEVPTGFPQNLHSEGTTS--TSVQLSWQPPVLAER 934
Query: 1671 NGNIQVYQALVYREDDPTAVQIHNLSIIQKTNTFVIAMLEGLKGGHTYNISVYAVNSAGA 1730
NG I Y L+YR+ + + + L + T L GLK TY++ V A S G
Sbjct: 935 NGIITKY-TLLYRDINIPLLPMEQLIVPADTTM----TLTGLKPDTTYDVKVRAHTSKGP 989
Query: 1731 GPKVP 1735
GP P
Sbjct: 990 GPYSP 994
Score = 53.9 bits (128), Expect = 2e-06
Identities = 103/456 (22%), Positives = 178/456 (39%), Gaps = 78/456 (17%)
Query: 9 LLFIGTSETQVDVSNVVPGTRYDITISSISTTYTSP--VTRIVTTNVTKP-GPPVFLAGE 65
+L I + T+ + + T Y IT+++ + P ++ ++ TN P GPP + E
Sbjct: 649 ILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVE 708
Query: 66 RVGSAGILLSWNTP-PNP-NGRIISYIVKYKEVC---PWMQTVYTQVRSKPDSLE----- 115
V S + +SW +P PN +G+I Y V Y + P Q + V E
Sbjct: 709 AVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDTT 768
Query: 116 ---VLLTNLNPGTTYEIKVAAENSAGIGVFSDPFLFQTAESAPGKVVNLTVEAYNASAVK 172
++++ L P T+Y + V A + G G S P L T + PGK L + +
Sbjct: 769 EHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGK-PRLVINHTQMNTAL 827
Query: 173 LIWYLP---------------RQPNGKITSFKISVKH-------------------ARSG 198
+ W+ P R+ +T+ + S K AR+
Sbjct: 828 IQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNK 887
Query: 199 I-----VVKDVSIRVEDILTGKLPECNENSESFLWSTASPSPTLGRVTPPSRTTH---SS 250
+ +VK++SI E++ TG P+ N +SE T S S L P + +
Sbjct: 888 VGFGEEMVKEISI-PEEVPTG-FPQ-NLHSE----GTTSTSVQLSWQPPVLAERNGIITK 940
Query: 251 STLTQNEIS--------SVWKEPISFVVTHLRPYTTYLFEVSAATTE--AGYIDSTIVRT 300
TL +I+ + + +T L+P TTY +V A T++ Y S RT
Sbjct: 941 YTLLYRDINIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRT 1000
Query: 301 PESVPEGPPQNCVTGNITGKSFSILWDPPTIVTGKFSYRVELYGPSGRILDNSTKDLKFA 360
V + +N + S + W+ P +++ LY + + + +
Sbjct: 1001 -LPVDQVFAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKI-LYDDGKMVEEVDGRATQKL 1058
Query: 361 FTNLTPFTMYDVYIAAETSAGTGPKSNISVFTPPDV 396
NL P Y + ++ G + ++ T PDV
Sbjct: 1059 IVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDV 1094
>gi|18860892 protein tyrosine phosphatase, receptor type, D isoform 3
precursor [Homo sapiens]
Length = 1903
Score = 248 bits (634), Expect = 4e-65
Identities = 155/446 (34%), Positives = 240/446 (53%), Gaps = 25/446 (5%)
Query: 1861 NGPLKPKKQYLFKFRATNIMGQ---FTDSDYSDPVKTLGEGLSERTVEI-----ILSVTL 1912
N L+ ++Y+F A + + S YSDPV ++ T E ++ L
Sbjct: 1207 NKQLQSGQEYVFFVLAVMEHAESKMYATSPYSDPVVSMDLDPQPITDEEEGLIWVVGPVL 1266
Query: 1913 CILSIILLGTAIFAFARIRQKQKEGGTYSPQDAEIIDTKLKLDQLITVADLELKDERLTR 1972
++ II + AI + R R + + P + EI +EL+ RL
Sbjct: 1267 AVVFIICIVIAILLYKRKRAESDSRKSSIPNNKEIPSHH-------PTDPVELR--RLNF 1317
Query: 1973 LLSYRKSIKPISKKSFLQHVEELCTNNNLKFQEEFSELPKFLQDLSSTDADLPWNRAKNR 2032
S PI H+E L N+NLKF +E+ + Q + ++L N+ KNR
Sbjct: 1318 QTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPG-QQFTWEHSNLEVNKPKNR 1376
Query: 2033 FPNIKPYNNNRVKLIADASVPGSDYINASYISGYLCPNEFIATQGPLPGTVGDFWRMVWE 2092
+ N+ Y+++RV L A +PGSDY+NA+YI GY N +IATQG LP T GDFWRM+WE
Sbjct: 1377 YANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWE 1436
Query: 2093 TRAKTLVMLTQCFEKGRIRCHQYWPEDNKPVTVFGDIVITKLMEDVQI-DWTIRDLKIER 2151
R+ T+VM+T+ E+ R++C QYWP ++ G + +T L++ V++ + +R + +
Sbjct: 1437 QRSATVVMMTKLEERSRVKCDQYWP--SRGTETHGLVQVT-LLDTVELATYCVRTFALYK 1493
Query: 2152 HG--DCMTVRQCNFTAWPEHGVPENSAPLIHFVKLVRASRAHDTTPMIVHCSAGVGRTGV 2209
+G + VRQ FTAWP+HGVPE+ P + F++ V+ D PM+VHCSAGVGRTG
Sbjct: 1494 NGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGC 1553
Query: 2210 FIALDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLLSNKGSNQPI 2269
FI +D + + I VDIYG V +R++R MVQ QYIF+H +L+ ++ + P
Sbjct: 1554 FIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPA 1613
Query: 2270 CFVNYSALQKMDSLDAMEGDVELEWE 2295
+ Y+ +QK+ ++ E +E E
Sbjct: 1614 RNL-YAYIQKLTQIETGENVTGMELE 1638
Score = 218 bits (556), Expect = 4e-56
Identities = 223/834 (26%), Positives = 360/834 (43%), Gaps = 70/834 (8%)
Query: 581 SSSSILLYWDP--PEYPNGKITHYTIYAMELDTNRAFQIT--TIDNSFLITGLKKYTKYK 636
+++SI L WD PE +++Y I ++ ++ + + GL Y+ Y+
Sbjct: 335 TATSITLTWDSGNPE----PVSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYE 390
Query: 637 MRVAASTHVGESSLSEENDIFVRTSEDEPESSPQDVEVIDVTADEIRLKWSPPEKPNGII 696
RV A ++G SE + +TSE P S+P+DV+ +++ I ++W PE+PNG I
Sbjct: 391 FRVVAVNNIGRGPPSEP--VLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQI 448
Query: 697 IAYEVLYKNIDTLYMKNTSTTDII------LRNLRPHTLYNISVRSYTRFGHGNQVSSLL 750
Y V Y T ++ N ++ + NL P Y++ V ++T G G +SS +
Sbjct: 449 QGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDG-PLSSDI 507
Query: 751 SVRTSETVPDSAPENITYKNISSGEIELSFLPPSSPNGIIQKYTIYLKRSNGNEERTINT 810
V T VP P N + S I LS+ PP S I +Y +G E+R
Sbjct: 508 QVITQTGVPGQ-PLNFKAEPESETSILLSWTPPRSDT-IANYELVYKDGEHGEEQRITIE 565
Query: 811 TSLTQNIKVLKKYTQYIIEVSASTLKGEGVRSAPISILTEEDAPDSPPQDFSVKQLSGVT 870
+ ++ LK + Y ++A + +G G +A IS T + P +PPQD S S +
Sbjct: 566 PGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTS 625
Query: 871 VKLSWQPP--LEPNGIILYYTVYVW-------NRSSLKTINVTETSLELSDLDYNVEYSA 921
+ +SWQPP + NGII Y++ + I T L L+ EY
Sbjct: 626 ILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRI 685
Query: 922 YVTASTRFGDGKTRSNIISFQTPEGAPSDPPKDVYYANLSSSSIILFWTP--PSKPNGII 979
VTA T G G +++ +T E PS PP+ V ++S+S+ + W P+K +G I
Sbjct: 686 TVTAHTDVGPGPESLSVL-IRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQI 744
Query: 980 QYYSVYY-RNTSGTFMQNFTLHEV-TNDFDNMTVSTIIDKLTIFSYYTFWLTASTSVGNG 1037
+ Y V+Y R +G L +V D +M +S + + + Y+ +TA T+ G+G
Sbjct: 745 RGYQVHYVRMENGEPKGQPMLKDVMLADAQDMIISGLQPETS----YSLTVTAYTTKGDG 800
Query: 1038 NKSSDIIEVYTDQDIPEGFVGNLTYESISSTAINVSWVPPAQPNGLVFYYVSLILQQTPR 1097
+S + V T +P G + + +TA+ + W PP G + Y + R
Sbjct: 801 ARSKPKL-VSTTGAVP-GKPRLVINHTQMNTAL-IQWHPPVDTFGPLQGY----RLKFGR 853
Query: 1098 HVRPPLVTYERSIYFD-----NLEKYTDYILKITPSTEKGFSDTYTAQLYIKTEEDVPET 1152
PL T E S D ++ K Y+ +++ + GF + ++ I E+VP
Sbjct: 854 KDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEEMVKEISI--PEEVPTG 911
Query: 1153 SPIINTFKNLSSTSVLLSWDPPV--KPNGAIISYDLTLQGPN-----ENYSFITSDNYII 1205
P + +STSV LSW PPV + NG I Y L + N + +D +
Sbjct: 912 FPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPADTTMT 971
Query: 1206 LEELSPFTLYSFFAAARTRKGLGPSSILFFYTDESVPLAPPQNLTLINCTSDFVWLKWSP 1265
L L P T Y A T KG GP S + V +N + V L W
Sbjct: 972 LTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVFAKNFHVKAVMKTSVLLSWE- 1030
Query: 1266 SPLPGGIVKVYSFKIHEHETDTIYYKNISGFKTEAKLVGLEPVSTYSIRVSAFTKVGNGN 1325
+P FKI + + + + G T+ +V L+P +YS F GN
Sbjct: 1031 --IPENYNSAMPFKILYDDGKMV--EEVDGRATQKLIVNLKPEKSYS-----FVLTNRGN 1081
Query: 1326 QFSNVVKFTTQESVPDVVQNMQCM--ATSWQSVLVKWDPPKKANGIITQYMVTV 1377
+ T ++ PDV++ T+ ++ P AN I Y + +
Sbjct: 1082 SAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPANENIKGYYIII 1135
Score = 214 bits (545), Expect = 8e-55
Identities = 199/702 (28%), Positives = 327/702 (46%), Gaps = 80/702 (11%)
Query: 531 YVIRRLVPFTEHMISVSAFTIMGEGPPTV-LSVRTRQQVPSSI-KIINYKNISSSSILLY 588
Y + L P++++ V A +G GPP+ + +T +Q PSS + + + +SS++IL+
Sbjct: 378 YSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQ 437
Query: 589 WDPPEYPNGKITHYTIYAMELDTNRA----------FQITTIDNSFLITGLKKYTKYKMR 638
W PE PNG+I Y +Y T QITTI N L Y ++
Sbjct: 438 WKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGN------LVPQKTYSVK 491
Query: 639 VAASTHVGESSLSEENDIFVRTSEDEPESSPQDVEVIDVTADEIRLKWSPPEKPNGIIIA 698
V A T +G+ LS +DI V T P P + + + I L W+PP + I
Sbjct: 492 VLAFTSIGDGPLS--SDIQVITQTGVP-GQPLNFKAEPESETSILLSWTPPR--SDTIAN 546
Query: 699 YEVLYKNIDTLYMKNTST---TDIILRNLRPHTLYNISVRSYTRFGHGNQVSSLLSVRTS 755
YE++YK+ + + + T L+ L+P++LY + + + G G + +S RT
Sbjct: 547 YELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAE-ISARTM 605
Query: 756 ETVPDSAPENITYKNISSGEIELSFLPP--SSPNGIIQKYTIYLKRSNGNEERT-----I 808
++ P + P++I+ + SS I +S+ PP NGII +Y+I +G +++ I
Sbjct: 606 QSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGI 665
Query: 809 NTTSLTQNIKVLKKYTQYIIEVSASTLKGEGVRSAPISILTEEDAPDSPPQDFSVKQLSG 868
+ + ++ L+K+T+Y I V+A T G G S + I T ED P PP+ V+ ++
Sbjct: 666 PSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNS 725
Query: 869 VTVKLSWQPPL--EPNGIILYYTVYVWNRSS--------LKTINVTET-SLELSDLDYNV 917
+VK+SW+ P+ + +G I Y V+ + LK + + + + +S L
Sbjct: 726 TSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQDMIISGLQPET 785
Query: 918 EYSAYVTASTRFGDGKTRSNIISFQTPEGAPSDPPKDVYYANLSSSSIILFWTPPSKPNG 977
YS VTA T GDG RS T P P + + ++++ ++ W PP G
Sbjct: 786 SYSLTVTAYTTKGDG-ARSKPKLVSTTGAVPGKPRLVINHTQMNTA--LIQWHPPVDTFG 842
Query: 978 IIQYYSVYYRNTSGTFMQNFTLHEVTNDFDNMTVSTIIDKLTIFSYYTFWLTASTSVGNG 1037
+Q Y + + M+ T E + D+ T + I + Y F L+A VG G
Sbjct: 843 PLQGYRLKFGRKD---MEPLTTLEFSEKEDHFTATDIHKGAS----YVFRLSARNKVGFG 895
Query: 1038 NKSSDIIEVYTDQDIPEGFVGNLTYESISSTAINVSWVPP--AQPNGLVFYYVSLILQQT 1095
+ + E+ +++P GF NL E +ST++ +SW PP A+ NG++ Y L
Sbjct: 896 EEM--VKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLY---- 949
Query: 1096 PRHVRPPLVTYERSIY-------FDNLEKYTDYILKITPSTEKGFSDTYTAQLYIKTEED 1148
R + PL+ E+ I L+ T Y +K+ T KG Y+ + +T
Sbjct: 950 -RDINIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKG-PGPYSPSVQFRT--- 1004
Query: 1149 VPETSPIINTF--KNLSSTSVLLSWDPPVKPNGAI---ISYD 1185
+P F K + TSVLLSW+ P N A+ I YD
Sbjct: 1005 LPVDQVFAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYD 1046
Score = 193 bits (491), Expect = 1e-48
Identities = 213/767 (27%), Positives = 341/767 (44%), Gaps = 71/767 (9%)
Query: 830 VSASTLKGEGVRSAPISILTEEDAPDSPPQDFSVKQLSGVTVKLSWQPPL-EPNGIILYY 888
V+ STL GV A I+ +T + P PP V + + ++ L+W EP + YY
Sbjct: 303 VAMSTL---GVIEA-IAQITVKALP-KPPGTPVVTESTATSITLTWDSGNPEP---VSYY 354
Query: 889 TVYVWNRSS---LKTIN-VTETSLELSDLDYNVEYSAYVTASTRFGDGKTRSNIISFQTP 944
+ ++S K I+ V T ++ L +Y V A G G +++ QT
Sbjct: 355 IIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLT-QTS 413
Query: 945 EGAPSDPPKDVYYANLSSSSIILFWTPPSKPNGIIQYYSVYYRNTSGTFMQNFTLHEVTN 1004
E APS P+DV LSS++I++ W P +PNG IQ Y VYY + N+ H V
Sbjct: 414 EQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVA- 472
Query: 1005 DFDNMTVSTIIDKLTIFSYYTFWLTASTSVGNGNKSSDIIEVYTDQDIPEGFVGNLTYES 1064
D T+ ++ + T Y+ + A TS+G+G SSDI +V T +P G N E
Sbjct: 473 DSQITTIGNLVPQKT----YSVKVLAFTSIGDGPLSSDI-QVITQTGVP-GQPLNFKAEP 526
Query: 1065 ISSTAINVSWVPPAQPNGLVFYYVSLILQQTPRHVRPPLVTYE--RSIYFDNLEKYTDYI 1122
S T+I +SW PP + + + Y ++ + H +T E S L+ + Y
Sbjct: 527 ESETSILLSWTPP-RSDTIANYE---LVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYY 582
Query: 1123 LKITPSTEKGFSDTYTAQLYIKTEEDVPETSPIINTFKNLSSTSVLLSWDPPV--KPNGA 1180
++ + +G + TA++ +T + P P + + SSTS+L+SW PP K NG
Sbjct: 583 FRLAARSPQGLGAS-TAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGI 641
Query: 1181 IISYDLTLQG-------PNENYSFITSDNYIILEELSPFTLYSFFAAARTRKGLGPSSI- 1232
I Y + P+E + +LE+L +T Y A T G GP S+
Sbjct: 642 ITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLS 701
Query: 1233 LFFYTDESVPLAPPQNLTLINCTSDFVWLKWSPSPLPGGIV-KVYSFKIHEHETDTIYYK 1291
+ T+E VP PP+ + + S V + W SP+P ++ +++H + K
Sbjct: 702 VLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWR-SPVPNKQHGQIRGYQVHYVRMENGEPK 760
Query: 1292 NISGFKT-------EAKLVGLEPVSTYSIRVSAFTKVGNGNQFSNVVKFTTQE--SVPDV 1342
K + + GL+P ++YS+ V+A+T G+G + + TT P +
Sbjct: 761 GQPMLKDVMLADAQDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGKPRL 820
Query: 1343 VQNMQCMATSWQSVLVKWDPPKKANGIITQYMVTVERN------STKVSPQDHMYTFIKL 1396
V N M T+ L++W PP G + Y + R + + S ++ +T +
Sbjct: 821 VINHTQMNTA----LIQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDI 876
Query: 1397 LANTSYVFKVRASTSAGEGDESTCHVSTLPETVPS-VPTNIAFSDVQSTSATLTWIRPDT 1455
SYVF++ A G G+E +S +PE VP+ P N+ STS L+W P
Sbjct: 877 HKGASYVFRLSARNKVGFGEEMVKEIS-IPEEVPTGFPQNLHSEGTTSTSVQLSWQPP-- 933
Query: 1456 ILGYFQNYKITTQLRAQKCKEWESEECVEYQKIQYLYEAHLTEETVYGLKKFRWYRFQVA 1515
+L +N IT + + + ++ L T T+ GLK Y +V
Sbjct: 934 VLAE-RNGIITKYTLLYR------DINIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVR 986
Query: 1516 ASTNAGYGNASNWISTKTLPGPPDGPPENVHVVATSPFSISISWSEP 1562
A T+ G G S + +TLP +N HV A S+ +SW P
Sbjct: 987 AHTSKGPGPYSPSVQFRTLP-VDQVFAKNFHVKAVMKTSVLLSWEIP 1032
Score = 193 bits (490), Expect = 2e-48
Identities = 114/282 (40%), Positives = 155/282 (54%), Gaps = 8/282 (2%)
Query: 1987 SFLQHVEELCTNNNLKFQE-EFSELPKFLQDLSS-TDADLPWNRAKNRFPNIKPYNNNRV 2044
+++Q + ++ T N+ E EF L S A+LP N+ KNR NI PY + RV
Sbjct: 1618 AYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRV 1677
Query: 2045 KLIADASVPGSDYINASYISGYLCPNEFIATQGPLPGTVGDFWRMVWETRAKTLVMLTQC 2104
L V GSDYINAS+I GY +IATQGPL T DFWRM+WE + +VMLT+
Sbjct: 1678 CLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKL 1737
Query: 2105 FEKGRIRCHQYWPEDNKPVTVFGDIVITKLMEDVQIDWTIRDLKI--ERHGDCMTVRQCN 2162
E GR +CHQYWP + + V+ + E + +R+ K+ R G TVRQ
Sbjct: 1738 REMGREKCHQYWPAERS--ARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQ 1795
Query: 2163 FTAWPEHGVPENSAPLIHFVKLVRASRAH--DTTPMIVHCSAGVGRTGVFIALDHLTQHI 2220
FT WPE GVP++ I F+ V ++ P+ VHCSAGVGRTGVFI L + + +
Sbjct: 1796 FTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERM 1855
Query: 2221 NDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLLSN 2262
VDI+ V LR++R MVQ QY F ++ L+ L +
Sbjct: 1856 RYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGS 1897
Score = 183 bits (464), Expect = 2e-45
Identities = 213/788 (27%), Positives = 322/788 (40%), Gaps = 84/788 (10%)
Query: 790 IQKYTIYLKRSNGNE-ERTINTTSLTQ-NIKVLKKYTQYIIEVSASTLKGEGVRSAPISI 847
+ Y I K N E + I+ + T+ ++ L Y+ Y V A G G S P+
Sbjct: 351 VSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLT 410
Query: 848 LTEEDAPDSPPQDFSVKQLSGVTVKLSWQPPLEPNGIILYYTVYV----------WNRSS 897
T E AP S P+D + LS T+ + W+ P EPNG I Y VY W + +
Sbjct: 411 QTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHN 470
Query: 898 LKTINVTETSLELSDLDYNVEYSAYVTASTRFGDGKTRSNIISFQTPEGAPSDPPKDVYY 957
+ +T + +L YS V A T GDG S+ I T G P P +
Sbjct: 471 VADSQIT----TIGNLVPQKTYSVKVLAFTSIGDGPLSSD-IQVITQTGVPGQ-PLNFKA 524
Query: 958 ANLSSSSIILFWTPPSKPNGIIQYYSVYYRNTSGTFMQNFTLHEVTNDFDNMTVSTIIDK 1017
S +SI+L WTPP + I Y + Y++ Q T+ T S +
Sbjct: 525 EPESETSILLSWTPPR--SDTIANYELVYKDGEHGEEQRITIEPGT--------SYRLQG 574
Query: 1018 LTIFSYYTFWLTASTSVGNGNKSSDIIEVYTDQDIPEGFVGNLTYESISSTAINVSWVPP 1077
L S Y F L A + G G +++ I T Q P +++ S SST+I VSW PP
Sbjct: 575 LKPNSLYYFRLAARSPQGLGASTAE-ISARTMQSKPSAPPQDISCTSPSSTSILVSWQPP 633
Query: 1078 --AQPNGLV----FYYVSLILQQTPRHVRPPLVTYERSIYFDNLEKYTDYILKITPSTEK 1131
+ NG++ Y ++ + H + + + LEK+T+Y + +T T+
Sbjct: 634 PVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDV 693
Query: 1132 GFSDTYTAQLYIKTEEDVPETSPIINTFKNLSSTSVLLSWDPPV--KPNGAIISYDL--- 1186
G + + I+T EDVP P + ++STSV +SW PV K +G I Y +
Sbjct: 694 G-PGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYV 752
Query: 1187 ------TLQGPNENYSFITSDNYIILEELSPFTLYSFFAAARTRKGLGP-SSILFFYTDE 1239
P + +I+ L P T YS A T KG G S T
Sbjct: 753 RMENGEPKGQPMLKDVMLADAQDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTG 812
Query: 1240 SVPLAPPQNLTLINCTSDFVWLKWSPSPLPGGIVKVYSFKIHEHETDTIYYKNISGFKTE 1299
+VP P L + + + ++W P G ++ Y K + + + S +
Sbjct: 813 AVPGKP--RLVINHTQMNTALIQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDH 870
Query: 1300 AKLVGLEPVSTYSIRVSAFTKVGNGNQFSNVVKFTTQESVP-DVVQNMQCMATSWQSVLV 1358
+ ++Y R+SA KVG G + V + + E VP QN+ T+ SV +
Sbjct: 871 FTATDIHKGASYVFRLSARNKVGFGEEM--VKEISIPEEVPTGFPQNLHSEGTTSTSVQL 928
Query: 1359 KWDPPKKA--NGIITQYM-------VTVERNSTKVSPQDHMYTFIKLLANTSYVFKVRAS 1409
W PP A NGIIT+Y + + + P D T L +T+Y KVRA
Sbjct: 929 SWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAH 988
Query: 1410 TSAGEGDES-TCHVSTLPETVPSV-PTNIAFSDVQSTSATLTWIRPDTILGYFQNYKITT 1467
TS G G S + TLP V V N V TS L+W P +NY
Sbjct: 989 TSKGPGPYSPSVQFRTLP--VDQVFAKNFHVKAVMKTSVLLSWEIP-------ENYNSAM 1039
Query: 1468 QLRAQKCKEWESEECVEYQKIQYLYEAHLTEETVYGLKKFRWYRFQVAASTNAGYGNASN 1527
+ ++ + VE + T++ + LK + Y F + N+ G +
Sbjct: 1040 PFKIL----YDDGKMVEE------VDGRATQKLIVNLKPEKSYSFVLTNRGNSA-GGLQH 1088
Query: 1528 WISTKTLP 1535
++ KT P
Sbjct: 1089 RVTAKTAP 1096
Score = 179 bits (455), Expect = 2e-44
Identities = 197/762 (25%), Positives = 335/762 (43%), Gaps = 82/762 (10%)
Query: 286 ATTEAGYIDSTIVRTPESVPEGPPQNCVTGNITGKSFSILWDPPT-------IVTGKFSY 338
A + G I++ T +++P+ PP V T S ++ WD I+ K
Sbjct: 304 AMSTLGVIEAIAQITVKALPK-PPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKN 362
Query: 339 RVELYGPSGRILDNSTKDLKFAFTNLTPFTMYDVYIAAETSAGTGPKSN-ISVFTPPDVP 397
ELY + +++ L+P++ Y+ + A + G GP S + T P
Sbjct: 363 SEELYKEIDGVATT-----RYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAP 417
Query: 398 G-AVFDLQLAEVESTQVRITWKKPRQPNGIINQYRVKVLVPETGII---LENTLLTGNNE 453
A D+Q + ST + + WK+P +PNG I YRV + T + +++ +
Sbjct: 418 SSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQIT 477
Query: 454 YINDPMAPEIVNIVEPMVGLYEGSAEMSSDLHSLATFIYNSHPDKNFPARNRAEDQTSPV 513
I + + P+ V+ + G +SSD+ + P NF A E +TS +
Sbjct: 478 TIGN-LVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQP-LNFKA--EPESETSIL 533
Query: 514 VTTRNQYITDIAAEQL-------------------SYVIRRLVPFTEHMISVSAFTIMGE 554
++ IA +L SY ++ L P + + ++A + G
Sbjct: 534 LSWTPPRSDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGL 593
Query: 555 GPPTV-LSVRTRQQVPSS-IKIINYKNISSSSILLYWDPP--EYPNGKITHYTI--YAME 608
G T +S RT Q PS+ + I+ + SS+SIL+ W PP E NG IT Y+I A++
Sbjct: 594 GASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVD 653
Query: 609 LDTNRAFQITTIDN---SFLITGLKKYTKYKMRVAASTHVGESSLSEENDIFVRTSEDEP 665
+ ++ +I I + +L+ L+K+T+Y++ V A T VG E + +RT+ED P
Sbjct: 654 GEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPG--PESLSVLIRTNEDVP 711
Query: 666 ESSPQDVEVIDVTADEIRLKW-SP-PEKPNGIIIAYEVLYKNIDTLYMKN---------T 714
P+ VEV V + +++ W SP P K +G I Y+V Y ++ K
Sbjct: 712 SGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLA 771
Query: 715 STTDIILRNLRPHTLYNISVRSYTRFGHGNQVSSLLSVRTSETVPDSAPENITYKNISSG 774
D+I+ L+P T Y+++V +YT G G + L V T+ VP I + +++
Sbjct: 772 DAQDMIISGLQPETSYSLTVTAYTTKGDGARSKPKL-VSTTGAVPGKPRLVINHTQMNTA 830
Query: 775 EIELSFLPPSSPNGIIQKYTIYLKRSNGNEERTINTTSLTQNIKV--LKKYTQYIIEVSA 832
I+ + PP G +Q Y + R + T+ + + + K Y+ +SA
Sbjct: 831 LIQ--WHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSA 888
Query: 833 STLKGEGVRSAPISILTEEDAPDSPPQDFSVKQLSGVTVKLSWQPPL--EPNGIILYYTV 890
G G I E+ P PQ+ + + +V+LSWQPP+ E NGII YT+
Sbjct: 889 RNKVGFGEEMVK-EISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTL 947
Query: 891 YVWNRS-----SLKTINVTETSLELSDLDYNVEYSAYVTASTRFGDGKTRSNIISFQTPE 945
+ + + I +T++ L+ L + Y V A T G G S + F+T
Sbjct: 948 LYRDINIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPG-PYSPSVQFRT-- 1004
Query: 946 GAPSDP--PKDVYYANLSSSSIILFWTPPSKPNGIIQYYSVY 985
P D K+ + + +S++L W P N + + +Y
Sbjct: 1005 -LPVDQVFAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILY 1045
Score = 154 bits (389), Expect = 1e-36
Identities = 182/754 (24%), Positives = 310/754 (41%), Gaps = 84/754 (11%)
Query: 908 LELSDLDYNVEYSAYVTASTRFGDGKTRSNIISFQTPEGAPSDPPKDVYYANLSSSSIIL 967
LEL+D+ + Y+ ++ + + + + P G P +++SI L
Sbjct: 289 LELNDVRQSANYTCVAMSTLGVIEAIAQITVKALPKPPGTP-------VVTESTATSITL 341
Query: 968 FWTPPSKPNGIIQYYSVYYRNTSGTFMQNFTLHEVTNDFDNM-TVSTIIDKLTIFSYYTF 1026
W + + YY + ++ + E+ + D + T + L+ +S Y F
Sbjct: 342 TWDSGNPEP--VSYYIIQHKPKNS--------EELYKEIDGVATTRYSVAGLSPYSDYEF 391
Query: 1027 WLTASTSVGNGNKSSDIIEVYTDQDIPEGFVGNLTYESISSTAINVSWVPPAQPNGLVFY 1086
+ A ++G G S ++ T + P ++ +SST I V W P +PNG +
Sbjct: 392 RVVAVNNIGRGPPSEPVL-TQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQG 450
Query: 1087 YVSLILQQTPRHVRPPL---VTYERSIYFDNLEKYTDYILKITPSTEKGFSDTYTAQLYI 1143
Y +HV + V + NL Y +K+ T G ++ + +
Sbjct: 451 YRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIG-DGPLSSDIQV 509
Query: 1144 KTEEDVPETSPIINTFKNLSSTSVLLSWDPPVKPNGAIISYDLTLQ----GPNENYSFIT 1199
T+ VP P+ + S TS+LLSW PP + I +Y+L + G + +
Sbjct: 510 ITQTGVPG-QPLNFKAEPESETSILLSWTPP--RSDTIANYELVYKDGEHGEEQRITIEP 566
Query: 1200 SDNYIILEELSPFTLYSFFAAARTRKGLGPSSI-LFFYTDESVPLAPPQNLTLINCTSDF 1258
+Y L+ L P +LY F AAR+ +GLG S+ + T +S P APPQ+++ + +S
Sbjct: 567 GTSYR-LQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTS 625
Query: 1259 VWLKWSPSPLP--GGIVKVYSFKIHEHETDTIYYKNISGFKTEAK---LVGLEPVSTYSI 1313
+ + W P P+ GI+ YS K + + I G ++ L LE + Y I
Sbjct: 626 ILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRI 685
Query: 1314 RVSAFTKVGNGNQFSNVVKFTTQESVPDVVQNMQCMATSWQSVLVKWDPP--KKANGIIT 1371
V+A T VG G + +V+ T ++ + ++ A + SV V W P K +G I
Sbjct: 686 TVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIR 745
Query: 1372 QYMV---TVERNSTKVSP--QDHMYTFIK------LLANTSYVFKVRASTSAGEGDESTC 1420
Y V +E K P +D M + L TSY V A T+ G+G S
Sbjct: 746 GYQVHYVRMENGEPKGQPMLKDVMLADAQDMIISGLQPETSYSLTVTAYTTKGDGARSKP 805
Query: 1421 HVSTLPETVPSVPTNIAFSDVQSTSATLTWIRPDTILGYFQNYKITTQLRAQKCKEWESE 1480
+ + VP P + + Q +A + W P G Q Y++ K+ E
Sbjct: 806 KLVSTTGAVPGKP-RLVINHTQMNTALIQWHPPVDTFGPLQGYRLKFGR-----KDMEPL 859
Query: 1481 ECVEYQKIQYLYEAHLTEETVYGLKKFRWYRFQVAASTNAGYGNASNWISTKTLPGP-PD 1539
+E+ + E H T ++ K Y F+++A G+G + ++P P
Sbjct: 860 TTLEFSE----KEDHFTATDIH---KGASYVFRLSARNKVGFGE--EMVKEISIPEEVPT 910
Query: 1540 GPPENVHVVATSPFSISISWSEP------AVITGPTCYLIDVKSVDNDEFNISFIKSNE- 1592
G P+N+H T+ S+ +SW P +IT T D+ NI + +
Sbjct: 911 GFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDI--------NIPLLPMEQL 962
Query: 1593 ---ENKTIEIKDLEIFTRYSVVITAFTGNISAAY 1623
+ T+ + L+ T Y V + A T Y
Sbjct: 963 IVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPY 996
Score = 140 bits (353), Expect = 1e-32
Identities = 194/850 (22%), Positives = 322/850 (37%), Gaps = 138/850 (16%)
Query: 13 GTSETQVDVSNVVPGTRYDITISSISTTYTSPVTRIVTTNVTKPGP---PVFLAGERVGS 69
G + T+ V+ + P + Y+ + +++ P + V T ++ P P + + S
Sbjct: 372 GVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSS 431
Query: 70 AGILLSWNTPPNPNGRIISYIVKY-----KEVCPWMQTVYTQVRSKPDSLEVLLTNLNPG 124
IL+ W P PNG+I Y V Y + V WM+ + DS + NL P
Sbjct: 432 TTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMK------HNVADSQITTIGNLVPQ 485
Query: 125 TTYEIKVAAENSAGIGVFSDPFLFQTAESAPGKVVNLTVEAYNASAVKLIWYLPRQPNGK 184
TY +KV A S G G S T PG+ +N E + +++ L W PR +
Sbjct: 486 KTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPR--SDT 543
Query: 185 ITSFKISVKHARSGIVVKDVSIRVEDILTGKLPECNENSESFLWSTASPSPTLGRVTPPS 244
I ++++ K G ++ I +E + +L NS + A LG T
Sbjct: 544 IANYELVYKDGEHG---EEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTA-- 598
Query: 245 RTTHSSSTLTQNEISSVWKEPISFVVTHLRPYTTYLFEVSAATTEAGYIDSTIVRTPESV 304
E+SA T + S
Sbjct: 599 -------------------------------------EISARTMQ-------------SK 608
Query: 305 PEGPPQNCVTGNITGKSFSILWDPPTIVTGK---FSYRVELYGPSG------RILDNSTK 355
P PPQ+ + + S + W PP + Y ++ G IL +
Sbjct: 609 PSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSD 668
Query: 356 DLKFAFTNLTPFTMYDVYIAAETSAGTGPKS-NISVFTPPDVP-GAVFDLQLAEVESTQV 413
K+ L +T Y + + A T G GP+S ++ + T DVP G +++ V ST V
Sbjct: 669 TTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSV 728
Query: 414 RITWKK--PRQPNGIINQYRVKVLVPETG-----IILENTLLTGNNEYINDPMAPEIVNI 466
+++W+ P + +G I Y+V + E G +L++ +L + I + PE
Sbjct: 729 KVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQDMIISGLQPETSYS 788
Query: 467 VEPMVGLYEGSAEMSSDLHSLATFIYNSHPDK--NFPARNRAEDQTSPVVTTRNQYITDI 524
+ +G S T P N N A Q P V T +
Sbjct: 789 LTVTAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNTALIQWHPPVDT----FGPL 844
Query: 525 AAEQLSYVIRRLVPFT--------------------EHMISVSAFTIMGEGPPTVLSVRT 564
+L + + + P T ++ +SA +G G V +
Sbjct: 845 QGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEEMVKEISI 904
Query: 565 RQQVPSSI-KIINYKNISSSSILLYWDPPEYP--NGKITHYTIYAMELD---TNRAFQIT 618
++VP+ + ++ + +S+S+ L W PP NG IT YT+ +++ I
Sbjct: 905 PEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIV 964
Query: 619 TIDNSFLITGLKKYTKYKMRVAASTHVGESSLSEENDIFVRTSEDEPESSPQDVEVIDVT 678
D + +TGLK T Y ++V A T G S + RT + + ++ V V
Sbjct: 965 PADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSP--SVQFRTLPVD-QVFAKNFHVKAVM 1021
Query: 679 ADEIRLKWSPPEKPNGIIIAYEVLYKNIDTLYMKNTSTTDIILRNLRPHTLYNISVRSYT 738
+ L W PE N + +++LY + + + T ++ NL+P Y S+
Sbjct: 1022 KTSVLLSWEIPENYNS-AMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKSY-----SFV 1075
Query: 739 RFGHGNQVSSLLSVRTSETVPD---SAPENITYKNISSGEIELSFLPPSSPNGIIQKYTI 795
GN L T++T PD + P I N+ G I + LP N I+ Y I
Sbjct: 1076 LTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNL-DGMITVQ-LPEVPANENIKGYYI 1133
Query: 796 Y---LKRSNG 802
LK+S G
Sbjct: 1134 IIVPLKKSRG 1143
Score = 135 bits (339), Expect = 6e-31
Identities = 133/529 (25%), Positives = 219/529 (41%), Gaps = 58/529 (10%)
Query: 1245 PPQNLTLINCTSDFVWLKW---SPSPLPGGIVKVYSFKIHEHETDTIYYKNISGFKTEA- 1300
PP + T+ + L W +P P+ I++ H+ + YK I G T
Sbjct: 325 PPGTPVVTESTATSITLTWDSGNPEPVSYYIIQ------HKPKNSEELYKEIDGVATTRY 378
Query: 1301 KLVGLEPVSTYSIRVSAFTKVGNGNQFSNVVKFTTQESVPDVVQNMQCMATSWQSVLVKW 1360
+ GL P S Y RV A +G G V+ T++++ +++Q S ++LV+W
Sbjct: 379 SVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQW 438
Query: 1361 DPPKKANGIITQYMVTVERNST-------KVSPQDHMYTFI-KLLANTSYVFKVRASTSA 1412
P++ NG I Y V + T K + D T I L+ +Y KV A TS
Sbjct: 439 KEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSI 498
Query: 1413 GEGDESTCHVSTLPET-VPSVPTNIAFSDVQSTSATLTWIRP--DTILGYFQNYKITTQL 1469
G+G S+ + + +T VP P N TS L+W P DTI Y YK
Sbjct: 499 GDGPLSS-DIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANYELVYKDG--- 554
Query: 1470 RAQKCKEWESEECVEYQKIQYLYEAHLTEETVYGLKKFRWYRFQVAASTNAGYGNASNWI 1529
E+ + Q + T + GLK Y F++AA + G G ++ I
Sbjct: 555 --------------EHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEI 600
Query: 1530 STKTLPGPPDGPPENVHVVATSPFSISISWSEP------AVITGPTCYLIDVKSVDNDEF 1583
S +T+ P PP+++ + S SI +SW P +IT + V D+
Sbjct: 601 SARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPH 660
Query: 1584 NISFIKSNEENKTIEIKDLEIFTRYSVVITAFTGNISAAYVEGKSSAEMIVTTLESAPKD 1643
I I S+ +E LE +T Y + +TA T G S +++ T E P
Sbjct: 661 EILGIPSDTTKYLLE--QLEKWTEYRITVTAHTD-----VGPGPESLSVLIRTNEDVPSG 713
Query: 1644 PPNNMTFQKIPDEVTKFQLTFLPPSQPNGNIQVYQALVYRED--DPTAVQIHNLSIIQKT 1701
PP + + + K P++ +G I+ YQ R + +P + ++
Sbjct: 714 PPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADA 773
Query: 1702 NTFVIAMLEGLKGGHTYNISVYAVNSAGAGPK-VPMRITMDIKAPARPK 1749
+I+ GL+ +Y+++V A + G G + P ++ P +P+
Sbjct: 774 QDMIIS---GLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGKPR 819
Score = 120 bits (300), Expect = 2e-26
Identities = 179/715 (25%), Positives = 266/715 (37%), Gaps = 96/715 (13%)
Query: 1066 SSTAINVSWVPPAQPNGLVFYYVSLILQQTPRHVRP------PLVTYERSIYFDNLEKYT 1119
++T+I ++W P + +Y I+Q P++ + T S+ L Y+
Sbjct: 335 TATSITLTW-DSGNPEPVSYY----IIQHKPKNSEELYKEIDGVATTRYSVA--GLSPYS 387
Query: 1120 DYILKITPSTEKGFSDTYTAQLYIKTEEDVPETSPIINTFKNLSSTSVLLSWDPPVKPNG 1179
DY ++ G + + +T E P ++P + LSST++L+ W P +PNG
Sbjct: 388 DYEFRVVAVNNIGRGPP-SEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNG 446
Query: 1180 AIISY------DLTLQGPNENYSFITSDNYIILEELSPFTLYSFFAAARTRKGLGP-SSI 1232
I Y D T N + + L P YS A T G GP SS
Sbjct: 447 QIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSD 506
Query: 1233 LFFYTDESVPLAPPQNLTLINCTSDFVWLKWSP--SPLPGGIVKVYSFKIHEHETDTIYY 1290
+ T VP P N + + L W+P S VY H E
Sbjct: 507 IQVITQTGVP-GQPLNFKAEPESETSILLSWTPPRSDTIANYELVYKDGEHGEEQRITIE 565
Query: 1291 KNISGFKTEAKLVGLEPVSTYSIRVSAFTKVGNGNQFSNVVKFTTQESVPDVVQNMQCMA 1350
T +L GL+P S Y R++A + G G + + T Q Q++ C +
Sbjct: 566 PG-----TSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTS 620
Query: 1351 TSWQSVLVKWDPP--KKANGIITQYMV---TVERNSTK------VSPQDHMYTFIKLLAN 1399
S S+LV W PP +K NGIIT+Y + V+ K + Y +L
Sbjct: 621 PSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKW 680
Query: 1400 TSYVFKVRASTSAGEGDESTCHVSTLPETVPS-VPTNIAFSDVQSTSATLTWIRP----- 1453
T Y V A T G G ES + E VPS P + V STS ++W P
Sbjct: 681 TEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQ 740
Query: 1454 -DTILGYFQNYKITTQLRAQKCKEWESEECVEYQKIQYLYEAHLTEETVYGLKKFRWYRF 1512
I GY +Y E+ E ++ + A + + GL+ Y
Sbjct: 741 HGQIRGYQVHYV-----------RMENGEPKGQPMLKDVMLADAQDMIISGLQPETSYSL 789
Query: 1513 QVAASTNAGYGNASNWISTKTLPGPPDGPPENVHVVATSPFSISISWSEPAVITGPTCYL 1572
V A T G G S T P P + + T + I W P GP
Sbjct: 790 TVTAYTTKGDGARSKPKLVSTTGAVPGKP--RLVINHTQMNTALIQWHPPVDTFGPL--- 844
Query: 1573 IDVKSVDNDEFNISF-IKSNEENKTIEIKDLEIFTRYSVVITAFTGNISAAYVEGKSSAE 1631
+ + F K E T+E + E TA + A+YV S+
Sbjct: 845 --------QGYRLKFGRKDMEPLTTLEFSEKEDH------FTATDIHKGASYVFRLSARN 890
Query: 1632 MI---------VTTLESAPKDPPNNMTFQKIPDEVTKFQLTFLPP--SQPNGNIQVYQAL 1680
+ ++ E P P N+ + T QL++ PP ++ NG I Y L
Sbjct: 891 KVGFGEEMVKEISIPEEVPTGFPQNLHSEGTTS--TSVQLSWQPPVLAERNGIITKY-TL 947
Query: 1681 VYREDDPTAVQIHNLSIIQKTNTFVIAMLEGLKGGHTYNISVYAVNSAGAGPKVP 1735
+YR+ + + + L + T L GLK TY++ V A S G GP P
Sbjct: 948 LYRDINIPLLPMEQLIVPADTTM----TLTGLKPDTTYDVKVRAHTSKGPGPYSP 998
Score = 59.3 bits (142), Expect = 4e-08
Identities = 103/448 (22%), Positives = 180/448 (40%), Gaps = 71/448 (15%)
Query: 9 LLFIGTSETQVDVSNVVPGTRYDITISSISTTYTSP--VTRIVTTNVTKP-GPPVFLAGE 65
+L I + T+ + + T Y IT+++ + P ++ ++ TN P GPP + E
Sbjct: 662 ILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVE 721
Query: 66 RVGSAGILLSWNTP-PNP-NGRIISYIVKYKEVC---PWMQTVYTQVRSKPDSLEVLLTN 120
V S + +SW +P PN +G+I Y V Y + P Q + V D+ +++++
Sbjct: 722 AVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLA-DAQDMIISG 780
Query: 121 LNPGTTYEIKVAAENSAGIGVFSDPFLFQTAESAPGKVVNLTVEAYNASAVKLIWYLP-- 178
L P T+Y + V A + G G S P L T + PGK L + + + W+ P
Sbjct: 781 LQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGK-PRLVINHTQMNTALIQWHPPVD 839
Query: 179 -------------RQPNGKITSFKISVKH-------------------ARSGI-----VV 201
R+ +T+ + S K AR+ + +V
Sbjct: 840 TFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEEMV 899
Query: 202 KDVSIRVEDILTGKLPECNENSESFLWSTASPSPTLGRVTPPSRTTH---SSSTLTQNEI 258
K++SI E++ TG P+ N +SE T S S L P + + TL +I
Sbjct: 900 KEISI-PEEVPTG-FPQ-NLHSE----GTTSTSVQLSWQPPVLAERNGIITKYTLLYRDI 952
Query: 259 S--------SVWKEPISFVVTHLRPYTTYLFEVSAATTE--AGYIDSTIVRTPESVPEGP 308
+ + + +T L+P TTY +V A T++ Y S RT V +
Sbjct: 953 NIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRT-LPVDQVF 1011
Query: 309 PQNCVTGNITGKSFSILWDPPTIVTGKFSYRVELYGPSGRILDNSTKDLKFAFTNLTPFT 368
+N + S + W+ P +++ LY + + + + NL P
Sbjct: 1012 AKNFHVKAVMKTSVLLSWEIPENYNSAMPFKI-LYDDGKMVEEVDGRATQKLIVNLKPEK 1070
Query: 369 MYDVYIAAETSAGTGPKSNISVFTPPDV 396
Y + ++ G + ++ T PDV
Sbjct: 1071 SYSFVLTNRGNSAGGLQHRVTAKTAPDV 1098
>gi|18860894 protein tyrosine phosphatase, receptor type, D isoform 4
precursor [Homo sapiens]
Length = 1501
Score = 248 bits (634), Expect = 4e-65
Identities = 155/446 (34%), Positives = 240/446 (53%), Gaps = 25/446 (5%)
Query: 1861 NGPLKPKKQYLFKFRATNIMGQ---FTDSDYSDPVKTLGEGLSERTVEI-----ILSVTL 1912
N L+ ++Y+F A + + S YSDPV ++ T E ++ L
Sbjct: 805 NKQLQSGQEYVFFVLAVMEHAESKMYATSPYSDPVVSMDLDPQPITDEEEGLIWVVGPVL 864
Query: 1913 CILSIILLGTAIFAFARIRQKQKEGGTYSPQDAEIIDTKLKLDQLITVADLELKDERLTR 1972
++ II + AI + R R + + P + EI +EL+ RL
Sbjct: 865 AVVFIICIVIAILLYKRKRAESDSRKSSIPNNKEIPSHH-------PTDPVELR--RLNF 915
Query: 1973 LLSYRKSIKPISKKSFLQHVEELCTNNNLKFQEEFSELPKFLQDLSSTDADLPWNRAKNR 2032
S PI H+E L N+NLKF +E+ + Q + ++L N+ KNR
Sbjct: 916 QTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPG-QQFTWEHSNLEVNKPKNR 974
Query: 2033 FPNIKPYNNNRVKLIADASVPGSDYINASYISGYLCPNEFIATQGPLPGTVGDFWRMVWE 2092
+ N+ Y+++RV L A +PGSDY+NA+YI GY N +IATQG LP T GDFWRM+WE
Sbjct: 975 YANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWE 1034
Query: 2093 TRAKTLVMLTQCFEKGRIRCHQYWPEDNKPVTVFGDIVITKLMEDVQI-DWTIRDLKIER 2151
R+ T+VM+T+ E+ R++C QYWP ++ G + +T L++ V++ + +R + +
Sbjct: 1035 QRSATVVMMTKLEERSRVKCDQYWP--SRGTETHGLVQVT-LLDTVELATYCVRTFALYK 1091
Query: 2152 HG--DCMTVRQCNFTAWPEHGVPENSAPLIHFVKLVRASRAHDTTPMIVHCSAGVGRTGV 2209
+G + VRQ FTAWP+HGVPE+ P + F++ V+ D PM+VHCSAGVGRTG
Sbjct: 1092 NGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGC 1151
Query: 2210 FIALDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLLSNKGSNQPI 2269
FI +D + + I VDIYG V +R++R MVQ QYIF+H +L+ ++ + P
Sbjct: 1152 FIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPA 1211
Query: 2270 CFVNYSALQKMDSLDAMEGDVELEWE 2295
+ Y+ +QK+ ++ E +E E
Sbjct: 1212 RNL-YAYIQKLTQIETGENVTGMELE 1236
Score = 193 bits (490), Expect = 2e-48
Identities = 114/282 (40%), Positives = 155/282 (54%), Gaps = 8/282 (2%)
Query: 1987 SFLQHVEELCTNNNLKFQE-EFSELPKFLQDLSS-TDADLPWNRAKNRFPNIKPYNNNRV 2044
+++Q + ++ T N+ E EF L S A+LP N+ KNR NI PY + RV
Sbjct: 1216 AYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRV 1275
Query: 2045 KLIADASVPGSDYINASYISGYLCPNEFIATQGPLPGTVGDFWRMVWETRAKTLVMLTQC 2104
L V GSDYINAS+I GY +IATQGPL T DFWRM+WE + +VMLT+
Sbjct: 1276 CLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKL 1335
Query: 2105 FEKGRIRCHQYWPEDNKPVTVFGDIVITKLMEDVQIDWTIRDLKI--ERHGDCMTVRQCN 2162
E GR +CHQYWP + + V+ + E + +R+ K+ R G TVRQ
Sbjct: 1336 REMGREKCHQYWPAERS--ARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQ 1393
Query: 2163 FTAWPEHGVPENSAPLIHFVKLVRASRAH--DTTPMIVHCSAGVGRTGVFIALDHLTQHI 2220
FT WPE GVP++ I F+ V ++ P+ VHCSAGVGRTGVFI L + + +
Sbjct: 1394 FTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERM 1453
Query: 2221 NDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLLSN 2262
VDI+ V LR++R MVQ QY F ++ L+ L +
Sbjct: 1454 RYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGS 1495
Score = 108 bits (269), Expect = 8e-23
Identities = 88/321 (27%), Positives = 150/321 (46%), Gaps = 22/321 (6%)
Query: 581 SSSSILLYWDP--PEYPNGKITHYTIYAMELDTNRAFQIT--TIDNSFLITGLKKYTKYK 636
+++SI L WD PE +++Y I ++ ++ + + GL Y+ Y+
Sbjct: 335 TATSITLTWDSGNPE----PVSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYE 390
Query: 637 MRVAASTHVGESSLSEENDIFVRTSEDEPESSPQDVEVIDVTADEIRLKWSPPEKPNGII 696
RV A ++G SE + +TSE P S+P+DV+ +++ I ++W PE+PNG I
Sbjct: 391 FRVVAVNNIGRGPPSEP--VLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQI 448
Query: 697 IAYEVLYKNIDTLYMKNTSTTDI------ILRNLRPHTLYNISVRSYTRFGHGNQVSSLL 750
Y V Y T ++ N ++ + NL P Y++ V ++T G G +SS +
Sbjct: 449 QGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDG-PLSSDI 507
Query: 751 SVRTSETVPDSAPENITYKNISSGEIELSFLPPSSPNGIIQKYTIYLKRSNGNEERTINT 810
V T VP P N + S I LS+ PP S + I +Y +G E+R
Sbjct: 508 QVITQTGVP-GQPLNFKAEPESETSILLSWTPPRS-DTIANYELVYKDGEHGEEQRITIE 565
Query: 811 TSLTQNIKVLKKYTQYIIEVSASTLKGEGVRSAPISILTEEDAPDSPPQDFSVKQLSGVT 870
+ ++ LK + Y ++A + +G G +A IS T + ++F VK + +
Sbjct: 566 PGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQ---SMFAKNFHVKAVMKTS 622
Query: 871 VKLSWQPPLEPNGIILYYTVY 891
V LSW+ P N + + +Y
Sbjct: 623 VLLSWEIPENYNSAMPFKILY 643
Score = 92.4 bits (228), Expect = 4e-18
Identities = 91/333 (27%), Positives = 139/333 (41%), Gaps = 42/333 (12%)
Query: 1245 PPQNLTLINCTSDFVWLKW---SPSPLPGGIVKVYSFKIHEHETDTIYYKNISGFKTEA- 1300
PP + T+ + L W +P P+ I++ H+ + YK I G T
Sbjct: 325 PPGTPVVTESTATSITLTWDSGNPEPVSYYIIQ------HKPKNSEELYKEIDGVATTRY 378
Query: 1301 KLVGLEPVSTYSIRVSAFTKVGNGNQFSNVVKFTTQESVPDVVQNMQCMATSWQSVLVKW 1360
+ GL P S Y RV A +G G V+ T++++ +++Q S ++LV+W
Sbjct: 379 SVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQW 438
Query: 1361 DPPKKANGIITQYMVTVERNST-------KVSPQDHMYTFI-KLLANTSYVFKVRASTSA 1412
P++ NG I Y V + T K + D T I L+ +Y KV A TS
Sbjct: 439 KEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSI 498
Query: 1413 GEGDESTCHVSTLPET-VPSVPTNIAFSDVQSTSATLTWIRP--DTILGYFQNYKITTQL 1469
G+G S+ + + +T VP P N TS L+W P DTI Y YK
Sbjct: 499 GDGPLSS-DIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANYELVYKDG--- 554
Query: 1470 RAQKCKEWESEECVEYQKIQYLYEAHLTEETVYGLKKFRWYRFQVAASTNAGYGNASNWI 1529
E+ + Q + T + GLK Y F++AA + G G ++ I
Sbjct: 555 --------------EHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEI 600
Query: 1530 STKTLPGPPDGPPENVHVVATSPFSISISWSEP 1562
S +T+ +N HV A S+ +SW P
Sbjct: 601 SARTMQSM---FAKNFHVKAVMKTSVLLSWEIP 630
Score = 91.3 bits (225), Expect = 1e-17
Identities = 102/405 (25%), Positives = 158/405 (39%), Gaps = 46/405 (11%)
Query: 790 IQKYTIYLKRSNGNE-ERTINTTSLTQ-NIKVLKKYTQYIIEVSASTLKGEGVRSAPISI 847
+ Y I K N E + I+ + T+ ++ L Y+ Y V A G G S P+
Sbjct: 351 VSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLT 410
Query: 848 LTEEDAPDSPPQDFSVKQLSGVTVKLSWQPPLEPNGIILYYTVYV----------WNRSS 897
T E AP S P+D + LS T+ + W+ P EPNG I Y VY W + +
Sbjct: 411 QTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHN 470
Query: 898 LKTINVTETSLELSDLDYNVEYSAYVTASTRFGDGKTRSNIISFQTPEGAPSDPPKDVYY 957
+ +T + +L YS V A T GDG S+ I T G P P +
Sbjct: 471 VADSQIT----TIGNLVPQKTYSVKVLAFTSIGDGPLSSD-IQVITQTGVPGQ-PLNFKA 524
Query: 958 ANLSSSSIILFWTPPSKPNGIIQYYSVYYRNTSGTFMQNFTLHEVTNDFDNMTVSTIIDK 1017
S +SI+L WTPP + I Y + Y++ Q T+ T S +
Sbjct: 525 EPESETSILLSWTPPR--SDTIANYELVYKDGEHGEEQRITIEPGT--------SYRLQG 574
Query: 1018 LTIFSYYTFWLTASTSVGNGNKSSDIIEVYTDQDIPEGFVGNLTYESISSTAINVSWVPP 1077
L S Y F L A + G G +++I + + + F N +++ T++ +SW P
Sbjct: 575 LKPNSLYYFRLAARSPQGLGASTAEI----SARTMQSMFAKNFHVKAVMKTSVLLSWEIP 630
Query: 1078 AQPNGL----VFYYVSLILQQTPRHVRPPLVTYERSIYFDNLEKYTDYILKITPSTEKGF 1133
N + Y ++++ L+ + EK ++L ++ G
Sbjct: 631 ENYNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKP------EKSYSFVLTNRGNSAGGL 684
Query: 1134 SDTYTAQLYIKTEEDVPETSPIINTFKNLSSTSVLLSWDPPVKPN 1178
TA KT DV T P NL + + P N
Sbjct: 685 QHRVTA----KTAPDVLRTKPAFIGKTNLDGMITVQLPEVPANEN 725
Score = 86.7 bits (213), Expect = 2e-16
Identities = 107/417 (25%), Positives = 182/417 (43%), Gaps = 39/417 (9%)
Query: 531 YVIRRLVPFTEHMISVSAFTIMGEGPPTV-LSVRTRQQVPSSI-KIINYKNISSSSILLY 588
Y + L P++++ V A +G GPP+ + +T +Q PSS + + + +SS++IL+
Sbjct: 378 YSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQ 437
Query: 589 WDPPEYPNGKITHYTIYAMELDTNRA----------FQITTIDNSFLITGLKKYTKYKMR 638
W PE PNG+I Y +Y T QITTI N L Y ++
Sbjct: 438 WKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGN------LVPQKTYSVK 491
Query: 639 VAASTHVGESSLSEENDIFVRTSEDEPESSPQDVEVIDVTADEIRLKWSPPEKPNGIIIA 698
V A T +G+ LS +DI V T P P + + + I L W+PP + I
Sbjct: 492 VLAFTSIGDGPLS--SDIQVITQTGVP-GQPLNFKAEPESETSILLSWTPPR--SDTIAN 546
Query: 699 YEVLYKNIDTLYMKNTST---TDIILRNLRPHTLYNISVRSYTRFGHGNQVSSLLSVRTS 755
YE++YK+ + + + T L+ L+P++LY + + + G G + + ++
Sbjct: 547 YELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEI----SA 602
Query: 756 ETVPDSAPENITYKNISSGEIELSFLPPSSPNGIIQKYTIYLKRSNGNEERTINTTSLTQ 815
T+ +N K + + LS+ P + N + +Y E T L
Sbjct: 603 RTMQSMFAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIV 662
Query: 816 NIKVLKKYTQYIIEVSASTLKGEGVRSAPISILTEEDAPDSPPQDFSVKQLSG-VTVKLS 874
N+K K Y+ +++ ++ G R ++ T D + P L G +TV+L
Sbjct: 663 NLKPEKSYS-FVLTNRGNSAGGLQHR---VTAKTAPDVLRTKPAFIGKTNLDGMITVQLP 718
Query: 875 WQPPLEPNGIILYYTVYV-WNRSSLKTINVTETSLELSDLDYNVEYSAYVTASTRFG 930
P E I YY + V +S K I E+ E+ +LD ++ + S R+G
Sbjct: 719 EVPANE--NIKGYYIIIVPLKKSRGKFIKPWESPDEM-ELDELLKEISRKRRSIRYG 772
Score = 72.4 bits (176), Expect = 5e-12
Identities = 64/263 (24%), Positives = 107/263 (40%), Gaps = 20/263 (7%)
Query: 13 GTSETQVDVSNVVPGTRYDITISSISTTYTSPVTRIVTTNVTKPGP---PVFLAGERVGS 69
G + T+ V+ + P + Y+ + +++ P + V T ++ P P + + S
Sbjct: 372 GVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSS 431
Query: 70 AGILLSWNTPPNPNGRIISYIVKY-----KEVCPWMQTVYTQVRSKPDSLEVLLTNLNPG 124
IL+ W P PNG+I Y V Y + V WM+ + DS + NL P
Sbjct: 432 TTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMK------HNVADSQITTIGNLVPQ 485
Query: 125 TTYEIKVAAENSAGIGVFSDPFLFQTAESAPGKVVNLTVEAYNASAVKLIWYLPRQPNGK 184
TY +KV A S G G S T PG+ +N E + +++ L W PR +
Sbjct: 486 KTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPR--SDT 543
Query: 185 ITSFKISVKHARSGIVVKDVSIRVEDILTGKLPECNENSESFLWSTASPSPTLGRVTPPS 244
I ++++ K G ++ I +E + +L NS + A LG T
Sbjct: 544 IANYELVYKDGEHG---EEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEI 600
Query: 245 RTTHSSSTLTQN-EISSVWKEPI 266
S +N + +V K +
Sbjct: 601 SARTMQSMFAKNFHVKAVMKTSV 623
Score = 70.5 bits (171), Expect = 2e-11
Identities = 101/444 (22%), Positives = 167/444 (37%), Gaps = 41/444 (9%)
Query: 1066 SSTAINVSWVPPAQPNGLVFYYVSLILQQTPRHVRP------PLVTYERSIYFDNLEKYT 1119
++T+I ++W P + +Y I+Q P++ + T S+ L Y+
Sbjct: 335 TATSITLTW-DSGNPEPVSYY----IIQHKPKNSEELYKEIDGVATTRYSVA--GLSPYS 387
Query: 1120 DYILKITPSTEKGFSDTYTAQLYIKTEEDVPETSPIINTFKNLSSTSVLLSWDPPVKPNG 1179
DY ++ G + + +T E P ++P + LSST++L+ W P +PNG
Sbjct: 388 DYEFRVVAVNNIGRGPP-SEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNG 446
Query: 1180 AIISY------DLTLQGPNENYSFITSDNYIILEELSPFTLYSFFAAARTRKGLGP-SSI 1232
I Y D T N + + L P YS A T G GP SS
Sbjct: 447 QIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSD 506
Query: 1233 LFFYTDESVPLAPPQNLTLINCTSDFVWLKWSP--SPLPGGIVKVYSFKIHEHETDTIYY 1290
+ T VP P N + + L W+P S VY H E
Sbjct: 507 IQVITQTGVP-GQPLNFKAEPESETSILLSWTPPRSDTIANYELVYKDGEHGEEQRITIE 565
Query: 1291 KNISGFKTEAKLVGLEPVSTYSIRVSAFTKVGNGNQFSNVVKFTTQESVPDVVQNMQCMA 1350
T +L GL+P S Y R++A + G G + + T Q +N A
Sbjct: 566 PG-----TSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSM---FAKNFHVKA 617
Query: 1351 TSWQSVLVKWDPPKKANGIIT-QYMVTVERNSTKVSPQDHMYTFIKLLANTSYVFKVRAS 1409
SVL+ W+ P+ N + + + + +V + + L SY F +
Sbjct: 618 VMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKSYSFVLTNR 677
Query: 1410 TSAGEGDESTCHVSTLPETVPSVPTNIAFSDVQSTSATLTWIRP-----DTILGYFQNYK 1464
++ G + T P+ + + P AF + +T P + I GY+
Sbjct: 678 GNSAGGLQHRVTAKTAPDVLRTKP---AFIGKTNLDGMITVQLPEVPANENIKGYYIIIV 734
Query: 1465 ITTQLRAQKCKEWESEECVEYQKI 1488
+ R + K WES + +E ++
Sbjct: 735 PLKKSRGKFIKPWESPDEMELDEL 758
Score = 69.7 bits (169), Expect = 3e-11
Identities = 94/416 (22%), Positives = 166/416 (39%), Gaps = 50/416 (12%)
Query: 286 ATTEAGYIDSTIVRTPESVPEGPPQNCVTGNITGKSFSILWDPPT-------IVTGKFSY 338
A + G I++ T +++P+ PP V T S ++ WD I+ K
Sbjct: 304 AMSTLGVIEAIAQITVKALPK-PPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKN 362
Query: 339 RVELYGPSGRILDNSTKDLKFAFTNLTPFTMYDVYIAAETSAGTGPKSN-ISVFTPPDVP 397
ELY + +++ L+P++ Y+ + A + G GP S + T P
Sbjct: 363 SEELYKEIDGVATT-----RYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAP 417
Query: 398 G-AVFDLQLAEVESTQVRITWKKPRQPNGIINQYRVKVLVPETGII---LENTLLTGNNE 453
A D+Q + ST + + WK+P +PNG I YRV + T + +++ +
Sbjct: 418 SSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQIT 477
Query: 454 YINDPMAPEIVNIVEPMVGLYEGSAEMSSDLHSLATFIYNSHPDKNFPARNRAEDQTSPV 513
I + + P+ V+ + G +SSD+ + P NF A E +TS +
Sbjct: 478 TIGN-LVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQP-LNFKA--EPESETSIL 533
Query: 514 VTTRNQYITDIAAEQL-------------------SYVIRRLVPFTEHMISVSAFTIMGE 554
++ IA +L SY ++ L P + + ++A + G
Sbjct: 534 LSWTPPRSDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGL 593
Query: 555 GPPTV-LSVRTRQQVPSSIKIINYKNISSSSILLYWDPPEYPNGKITHYTIYAMELDTNR 613
G T +S RT Q + K + K + +S+LL W+ PE N + +Y D
Sbjct: 594 GASTAEISARTMQSM--FAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYD---DGKM 648
Query: 614 AFQITTIDNSFLITGLKKYTKYKMRVAASTHVGESSLSEENDIFVRTSEDEPESSP 669
++ LI LK Y T+ G S+ ++ + +T+ D + P
Sbjct: 649 VEEVDGRATQKLIVNLKPEKSYSF---VLTNRGNSAGGLQHRVTAKTAPDVLRTKP 701
Score = 48.1 bits (113), Expect = 1e-04
Identities = 58/229 (25%), Positives = 90/229 (39%), Gaps = 34/229 (14%)
Query: 1512 FQVAASTNAGYGNASNWISTKTLPGPPDGPPENVHVVATSPFSISISWS----EPAVITG 1567
+ A + G A I+ K LP PP P V ++ SI+++W EP
Sbjct: 300 YTCVAMSTLGVIEAIAQITVKALPKPPGTPV----VTESTATSITLTWDSGNPEPV---- 351
Query: 1568 PTCYLIDVKSVDNDEFNISFIKSNEENKTIEIKDLEIFTRYSVVITAFTGNISAAYVEGK 1627
+ Y+I K +++E + L ++ Y + A NI G
Sbjct: 352 -SYYIIQHKPKNSEELYKEI--DGVATTRYSVAGLSPYSDYEFRVVA-VNNIG----RGP 403
Query: 1628 SSAEMIVTTLESAPKDPPNNMTFQKIPDEVTKFQLTFLPPSQPNGNIQVYQALVYREDDP 1687
S ++ T E AP P ++ + + T + + P +PNG IQ Y+ VY DP
Sbjct: 404 PSEPVLTQTSEQAPSSAPRDVQARMLSS--TTILVQWKEPEEPNGQIQGYR--VYYTMDP 459
Query: 1688 TAV----QIHNLSIIQKTNTFVIAMLEGLKGGHTYNISVYAVNSAGAGP 1732
T HN++ Q I + L TY++ V A S G GP
Sbjct: 460 TQHVNNWMKHNVADSQ------ITTIGNLVPQKTYSVKVLAFTSIGDGP 502
>gi|104487002 protein tyrosine phosphatase, receptor type, D isoform 5
precursor [Homo sapiens]
Length = 1502
Score = 246 bits (629), Expect = 1e-64
Identities = 151/443 (34%), Positives = 238/443 (53%), Gaps = 15/443 (3%)
Query: 1861 NGPLKPKKQYLFKFRATNIMGQ---FTDSDYSDPVKTLGEGLSERTVEI--ILSVTLCIL 1915
N L+ ++Y+F A + + S YSDPV ++ T E ++ V +L
Sbjct: 802 NKQLQSGQEYVFFVLAVMEHAESKMYATSPYSDPVVSMDLDPQPITDEEEGLIWVVGPVL 861
Query: 1916 SIILLGTAIFAFARIRQKQKEGGTYSPQDAEIIDTKLKLDQLITVADLELKDERLTRLLS 1975
+++ + + A + K S I ++ +EL+ RL
Sbjct: 862 AVVFIICIVIAILLYKSKPDRKRAESDSRKSSIPNNKEIPSHHPTDPVELR--RLNFQTP 919
Query: 1976 YRKSIKPISKKSFLQHVEELCTNNNLKFQEEFSELPKFLQDLSSTDADLPWNRAKNRFPN 2035
S PI H+E L N+NLKF +E+ + Q + ++L N+ KNR+ N
Sbjct: 920 GMASHPPIPILELADHIERLKANDNLKFSQEYESIDPG-QQFTWEHSNLEVNKPKNRYAN 978
Query: 2036 IKPYNNNRVKLIADASVPGSDYINASYISGYLCPNEFIATQGPLPGTVGDFWRMVWETRA 2095
+ Y+++RV L A +PGSDY+NA+YI GY N +IATQG LP T GDFWRM+WE R+
Sbjct: 979 VIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRS 1038
Query: 2096 KTLVMLTQCFEKGRIRCHQYWPEDNKPVTVFGDIVITKLMEDVQI-DWTIRDLKIERHG- 2153
T+VM+T+ E+ R++C QYWP ++ G + +T L++ V++ + +R + ++G
Sbjct: 1039 ATVVMMTKLEERSRVKCDQYWP--SRGTETHGLVQVT-LLDTVELATYCVRTFALYKNGS 1095
Query: 2154 -DCMTVRQCNFTAWPEHGVPENSAPLIHFVKLVRASRAHDTTPMIVHCSAGVGRTGVFIA 2212
+ VRQ FTAWP+HGVPE+ P + F++ V+ D PM+VHCSAGVGRTG FI
Sbjct: 1096 SEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIV 1155
Query: 2213 LDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLLSNKGSNQPICFV 2272
+D + + I VDIYG V +R++R MVQ QYIF+H +L+ ++ + P +
Sbjct: 1156 IDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNL 1215
Query: 2273 NYSALQKMDSLDAMEGDVELEWE 2295
Y+ +QK+ ++ E +E E
Sbjct: 1216 -YAYIQKLTQIETGENVTGMELE 1237
Score = 193 bits (490), Expect = 2e-48
Identities = 114/282 (40%), Positives = 155/282 (54%), Gaps = 8/282 (2%)
Query: 1987 SFLQHVEELCTNNNLKFQE-EFSELPKFLQDLSS-TDADLPWNRAKNRFPNIKPYNNNRV 2044
+++Q + ++ T N+ E EF L S A+LP N+ KNR NI PY + RV
Sbjct: 1217 AYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRV 1276
Query: 2045 KLIADASVPGSDYINASYISGYLCPNEFIATQGPLPGTVGDFWRMVWETRAKTLVMLTQC 2104
L V GSDYINAS+I GY +IATQGPL T DFWRM+WE + +VMLT+
Sbjct: 1277 CLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKL 1336
Query: 2105 FEKGRIRCHQYWPEDNKPVTVFGDIVITKLMEDVQIDWTIRDLKI--ERHGDCMTVRQCN 2162
E GR +CHQYWP + + V+ + E + +R+ K+ R G TVRQ
Sbjct: 1337 REMGREKCHQYWPAERS--ARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQ 1394
Query: 2163 FTAWPEHGVPENSAPLIHFVKLVRASRAH--DTTPMIVHCSAGVGRTGVFIALDHLTQHI 2220
FT WPE GVP++ I F+ V ++ P+ VHCSAGVGRTGVFI L + + +
Sbjct: 1395 FTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERM 1454
Query: 2221 NDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLLSN 2262
VDI+ V LR++R MVQ QY F ++ L+ L +
Sbjct: 1455 RYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGS 1496
Score = 108 bits (269), Expect = 8e-23
Identities = 88/321 (27%), Positives = 150/321 (46%), Gaps = 22/321 (6%)
Query: 581 SSSSILLYWDP--PEYPNGKITHYTIYAMELDTNRAFQIT--TIDNSFLITGLKKYTKYK 636
+++SI L WD PE +++Y I ++ ++ + + GL Y+ Y+
Sbjct: 332 TATSITLTWDSGNPE----PVSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYE 387
Query: 637 MRVAASTHVGESSLSEENDIFVRTSEDEPESSPQDVEVIDVTADEIRLKWSPPEKPNGII 696
RV A ++G SE + +TSE P S+P+DV+ +++ I ++W PE+PNG I
Sbjct: 388 FRVVAVNNIGRGPPSEP--VLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQI 445
Query: 697 IAYEVLYKNIDTLYMKNTSTTDI------ILRNLRPHTLYNISVRSYTRFGHGNQVSSLL 750
Y V Y T ++ N ++ + NL P Y++ V ++T G G +SS +
Sbjct: 446 QGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDG-PLSSDI 504
Query: 751 SVRTSETVPDSAPENITYKNISSGEIELSFLPPSSPNGIIQKYTIYLKRSNGNEERTINT 810
V T VP P N + S I LS+ PP S + I +Y +G E+R
Sbjct: 505 QVITQTGVP-GQPLNFKAEPESETSILLSWTPPRS-DTIANYELVYKDGEHGEEQRITIE 562
Query: 811 TSLTQNIKVLKKYTQYIIEVSASTLKGEGVRSAPISILTEEDAPDSPPQDFSVKQLSGVT 870
+ ++ LK + Y ++A + +G G +A IS T + ++F VK + +
Sbjct: 563 PGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQ---SMFAKNFHVKAVMKTS 619
Query: 871 VKLSWQPPLEPNGIILYYTVY 891
V LSW+ P N + + +Y
Sbjct: 620 VLLSWEIPENYNSAMPFKILY 640
Score = 92.4 bits (228), Expect = 4e-18
Identities = 91/333 (27%), Positives = 139/333 (41%), Gaps = 42/333 (12%)
Query: 1245 PPQNLTLINCTSDFVWLKW---SPSPLPGGIVKVYSFKIHEHETDTIYYKNISGFKTEA- 1300
PP + T+ + L W +P P+ I++ H+ + YK I G T
Sbjct: 322 PPGTPVVTESTATSITLTWDSGNPEPVSYYIIQ------HKPKNSEELYKEIDGVATTRY 375
Query: 1301 KLVGLEPVSTYSIRVSAFTKVGNGNQFSNVVKFTTQESVPDVVQNMQCMATSWQSVLVKW 1360
+ GL P S Y RV A +G G V+ T++++ +++Q S ++LV+W
Sbjct: 376 SVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQW 435
Query: 1361 DPPKKANGIITQYMVTVERNST-------KVSPQDHMYTFI-KLLANTSYVFKVRASTSA 1412
P++ NG I Y V + T K + D T I L+ +Y KV A TS
Sbjct: 436 KEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSI 495
Query: 1413 GEGDESTCHVSTLPET-VPSVPTNIAFSDVQSTSATLTWIRP--DTILGYFQNYKITTQL 1469
G+G S+ + + +T VP P N TS L+W P DTI Y YK
Sbjct: 496 GDGPLSS-DIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANYELVYKDG--- 551
Query: 1470 RAQKCKEWESEECVEYQKIQYLYEAHLTEETVYGLKKFRWYRFQVAASTNAGYGNASNWI 1529
E+ + Q + T + GLK Y F++AA + G G ++ I
Sbjct: 552 --------------EHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEI 597
Query: 1530 STKTLPGPPDGPPENVHVVATSPFSISISWSEP 1562
S +T+ +N HV A S+ +SW P
Sbjct: 598 SARTMQSM---FAKNFHVKAVMKTSVLLSWEIP 627
Score = 91.3 bits (225), Expect = 1e-17
Identities = 102/405 (25%), Positives = 158/405 (39%), Gaps = 46/405 (11%)
Query: 790 IQKYTIYLKRSNGNE-ERTINTTSLTQ-NIKVLKKYTQYIIEVSASTLKGEGVRSAPISI 847
+ Y I K N E + I+ + T+ ++ L Y+ Y V A G G S P+
Sbjct: 348 VSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLT 407
Query: 848 LTEEDAPDSPPQDFSVKQLSGVTVKLSWQPPLEPNGIILYYTVYV----------WNRSS 897
T E AP S P+D + LS T+ + W+ P EPNG I Y VY W + +
Sbjct: 408 QTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHN 467
Query: 898 LKTINVTETSLELSDLDYNVEYSAYVTASTRFGDGKTRSNIISFQTPEGAPSDPPKDVYY 957
+ +T + +L YS V A T GDG S+ I T G P P +
Sbjct: 468 VADSQIT----TIGNLVPQKTYSVKVLAFTSIGDGPLSSD-IQVITQTGVPGQ-PLNFKA 521
Query: 958 ANLSSSSIILFWTPPSKPNGIIQYYSVYYRNTSGTFMQNFTLHEVTNDFDNMTVSTIIDK 1017
S +SI+L WTPP + I Y + Y++ Q T+ T S +
Sbjct: 522 EPESETSILLSWTPPR--SDTIANYELVYKDGEHGEEQRITIEPGT--------SYRLQG 571
Query: 1018 LTIFSYYTFWLTASTSVGNGNKSSDIIEVYTDQDIPEGFVGNLTYESISSTAINVSWVPP 1077
L S Y F L A + G G +++I + + + F N +++ T++ +SW P
Sbjct: 572 LKPNSLYYFRLAARSPQGLGASTAEI----SARTMQSMFAKNFHVKAVMKTSVLLSWEIP 627
Query: 1078 AQPNGL----VFYYVSLILQQTPRHVRPPLVTYERSIYFDNLEKYTDYILKITPSTEKGF 1133
N + Y ++++ L+ + EK ++L ++ G
Sbjct: 628 ENYNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKP------EKSYSFVLTNRGNSAGGL 681
Query: 1134 SDTYTAQLYIKTEEDVPETSPIINTFKNLSSTSVLLSWDPPVKPN 1178
TA KT DV T P NL + + P N
Sbjct: 682 QHRVTA----KTAPDVLRTKPAFIGKTNLDGMITVQLPEVPANEN 722
Score = 86.7 bits (213), Expect = 2e-16
Identities = 107/417 (25%), Positives = 182/417 (43%), Gaps = 39/417 (9%)
Query: 531 YVIRRLVPFTEHMISVSAFTIMGEGPPTV-LSVRTRQQVPSSI-KIINYKNISSSSILLY 588
Y + L P++++ V A +G GPP+ + +T +Q PSS + + + +SS++IL+
Sbjct: 375 YSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQ 434
Query: 589 WDPPEYPNGKITHYTIYAMELDTNRA----------FQITTIDNSFLITGLKKYTKYKMR 638
W PE PNG+I Y +Y T QITTI N L Y ++
Sbjct: 435 WKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGN------LVPQKTYSVK 488
Query: 639 VAASTHVGESSLSEENDIFVRTSEDEPESSPQDVEVIDVTADEIRLKWSPPEKPNGIIIA 698
V A T +G+ LS +DI V T P P + + + I L W+PP + I
Sbjct: 489 VLAFTSIGDGPLS--SDIQVITQTGVP-GQPLNFKAEPESETSILLSWTPPR--SDTIAN 543
Query: 699 YEVLYKNIDTLYMKNTST---TDIILRNLRPHTLYNISVRSYTRFGHGNQVSSLLSVRTS 755
YE++YK+ + + + T L+ L+P++LY + + + G G + + ++
Sbjct: 544 YELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEI----SA 599
Query: 756 ETVPDSAPENITYKNISSGEIELSFLPPSSPNGIIQKYTIYLKRSNGNEERTINTTSLTQ 815
T+ +N K + + LS+ P + N + +Y E T L
Sbjct: 600 RTMQSMFAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIV 659
Query: 816 NIKVLKKYTQYIIEVSASTLKGEGVRSAPISILTEEDAPDSPPQDFSVKQLSG-VTVKLS 874
N+K K Y+ +++ ++ G R ++ T D + P L G +TV+L
Sbjct: 660 NLKPEKSYS-FVLTNRGNSAGGLQHR---VTAKTAPDVLRTKPAFIGKTNLDGMITVQLP 715
Query: 875 WQPPLEPNGIILYYTVYV-WNRSSLKTINVTETSLELSDLDYNVEYSAYVTASTRFG 930
P E I YY + V +S K I E+ E+ +LD ++ + S R+G
Sbjct: 716 EVPANE--NIKGYYIIIVPLKKSRGKFIKPWESPDEM-ELDELLKEISRKRRSIRYG 769
Score = 72.4 bits (176), Expect = 5e-12
Identities = 64/263 (24%), Positives = 107/263 (40%), Gaps = 20/263 (7%)
Query: 13 GTSETQVDVSNVVPGTRYDITISSISTTYTSPVTRIVTTNVTKPGP---PVFLAGERVGS 69
G + T+ V+ + P + Y+ + +++ P + V T ++ P P + + S
Sbjct: 369 GVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSS 428
Query: 70 AGILLSWNTPPNPNGRIISYIVKY-----KEVCPWMQTVYTQVRSKPDSLEVLLTNLNPG 124
IL+ W P PNG+I Y V Y + V WM+ + DS + NL P
Sbjct: 429 TTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMK------HNVADSQITTIGNLVPQ 482
Query: 125 TTYEIKVAAENSAGIGVFSDPFLFQTAESAPGKVVNLTVEAYNASAVKLIWYLPRQPNGK 184
TY +KV A S G G S T PG+ +N E + +++ L W PR +
Sbjct: 483 KTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPR--SDT 540
Query: 185 ITSFKISVKHARSGIVVKDVSIRVEDILTGKLPECNENSESFLWSTASPSPTLGRVTPPS 244
I ++++ K G ++ I +E + +L NS + A LG T
Sbjct: 541 IANYELVYKDGEHG---EEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEI 597
Query: 245 RTTHSSSTLTQN-EISSVWKEPI 266
S +N + +V K +
Sbjct: 598 SARTMQSMFAKNFHVKAVMKTSV 620
Score = 70.5 bits (171), Expect = 2e-11
Identities = 101/444 (22%), Positives = 167/444 (37%), Gaps = 41/444 (9%)
Query: 1066 SSTAINVSWVPPAQPNGLVFYYVSLILQQTPRHVRP------PLVTYERSIYFDNLEKYT 1119
++T+I ++W P + +Y I+Q P++ + T S+ L Y+
Sbjct: 332 TATSITLTW-DSGNPEPVSYY----IIQHKPKNSEELYKEIDGVATTRYSVA--GLSPYS 384
Query: 1120 DYILKITPSTEKGFSDTYTAQLYIKTEEDVPETSPIINTFKNLSSTSVLLSWDPPVKPNG 1179
DY ++ G + + +T E P ++P + LSST++L+ W P +PNG
Sbjct: 385 DYEFRVVAVNNIGRGPP-SEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNG 443
Query: 1180 AIISY------DLTLQGPNENYSFITSDNYIILEELSPFTLYSFFAAARTRKGLGP-SSI 1232
I Y D T N + + L P YS A T G GP SS
Sbjct: 444 QIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSD 503
Query: 1233 LFFYTDESVPLAPPQNLTLINCTSDFVWLKWSP--SPLPGGIVKVYSFKIHEHETDTIYY 1290
+ T VP P N + + L W+P S VY H E
Sbjct: 504 IQVITQTGVP-GQPLNFKAEPESETSILLSWTPPRSDTIANYELVYKDGEHGEEQRITIE 562
Query: 1291 KNISGFKTEAKLVGLEPVSTYSIRVSAFTKVGNGNQFSNVVKFTTQESVPDVVQNMQCMA 1350
T +L GL+P S Y R++A + G G + + T Q +N A
Sbjct: 563 PG-----TSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSM---FAKNFHVKA 614
Query: 1351 TSWQSVLVKWDPPKKANGIIT-QYMVTVERNSTKVSPQDHMYTFIKLLANTSYVFKVRAS 1409
SVL+ W+ P+ N + + + + +V + + L SY F +
Sbjct: 615 VMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKSYSFVLTNR 674
Query: 1410 TSAGEGDESTCHVSTLPETVPSVPTNIAFSDVQSTSATLTWIRP-----DTILGYFQNYK 1464
++ G + T P+ + + P AF + +T P + I GY+
Sbjct: 675 GNSAGGLQHRVTAKTAPDVLRTKP---AFIGKTNLDGMITVQLPEVPANENIKGYYIIIV 731
Query: 1465 ITTQLRAQKCKEWESEECVEYQKI 1488
+ R + K WES + +E ++
Sbjct: 732 PLKKSRGKFIKPWESPDEMELDEL 755
Score = 69.7 bits (169), Expect = 3e-11
Identities = 94/416 (22%), Positives = 166/416 (39%), Gaps = 50/416 (12%)
Query: 286 ATTEAGYIDSTIVRTPESVPEGPPQNCVTGNITGKSFSILWDPPT-------IVTGKFSY 338
A + G I++ T +++P+ PP V T S ++ WD I+ K
Sbjct: 301 AMSTLGVIEAIAQITVKALPK-PPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKN 359
Query: 339 RVELYGPSGRILDNSTKDLKFAFTNLTPFTMYDVYIAAETSAGTGPKSN-ISVFTPPDVP 397
ELY + +++ L+P++ Y+ + A + G GP S + T P
Sbjct: 360 SEELYKEIDGVATT-----RYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAP 414
Query: 398 G-AVFDLQLAEVESTQVRITWKKPRQPNGIINQYRVKVLVPETGII---LENTLLTGNNE 453
A D+Q + ST + + WK+P +PNG I YRV + T + +++ +
Sbjct: 415 SSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQIT 474
Query: 454 YINDPMAPEIVNIVEPMVGLYEGSAEMSSDLHSLATFIYNSHPDKNFPARNRAEDQTSPV 513
I + + P+ V+ + G +SSD+ + P NF A E +TS +
Sbjct: 475 TIGN-LVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQP-LNFKA--EPESETSIL 530
Query: 514 VTTRNQYITDIAAEQL-------------------SYVIRRLVPFTEHMISVSAFTIMGE 554
++ IA +L SY ++ L P + + ++A + G
Sbjct: 531 LSWTPPRSDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGL 590
Query: 555 GPPTV-LSVRTRQQVPSSIKIINYKNISSSSILLYWDPPEYPNGKITHYTIYAMELDTNR 613
G T +S RT Q + K + K + +S+LL W+ PE N + +Y D
Sbjct: 591 GASTAEISARTMQSM--FAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYD---DGKM 645
Query: 614 AFQITTIDNSFLITGLKKYTKYKMRVAASTHVGESSLSEENDIFVRTSEDEPESSP 669
++ LI LK Y T+ G S+ ++ + +T+ D + P
Sbjct: 646 VEEVDGRATQKLIVNLKPEKSYSF---VLTNRGNSAGGLQHRVTAKTAPDVLRTKP 698
Score = 48.1 bits (113), Expect = 1e-04
Identities = 58/229 (25%), Positives = 90/229 (39%), Gaps = 34/229 (14%)
Query: 1512 FQVAASTNAGYGNASNWISTKTLPGPPDGPPENVHVVATSPFSISISWS----EPAVITG 1567
+ A + G A I+ K LP PP P V ++ SI+++W EP
Sbjct: 297 YTCVAMSTLGVIEAIAQITVKALPKPPGTPV----VTESTATSITLTWDSGNPEPV---- 348
Query: 1568 PTCYLIDVKSVDNDEFNISFIKSNEENKTIEIKDLEIFTRYSVVITAFTGNISAAYVEGK 1627
+ Y+I K +++E + L ++ Y + A NI G
Sbjct: 349 -SYYIIQHKPKNSEELYKEI--DGVATTRYSVAGLSPYSDYEFRVVA-VNNIG----RGP 400
Query: 1628 SSAEMIVTTLESAPKDPPNNMTFQKIPDEVTKFQLTFLPPSQPNGNIQVYQALVYREDDP 1687
S ++ T E AP P ++ + + T + + P +PNG IQ Y+ VY DP
Sbjct: 401 PSEPVLTQTSEQAPSSAPRDVQARMLSS--TTILVQWKEPEEPNGQIQGYR--VYYTMDP 456
Query: 1688 TAV----QIHNLSIIQKTNTFVIAMLEGLKGGHTYNISVYAVNSAGAGP 1732
T HN++ Q I + L TY++ V A S G GP
Sbjct: 457 TQHVNNWMKHNVADSQ------ITTIGNLVPQKTYSVKVLAFTSIGDGP 499
>gi|119220552 sidekick 1 [Homo sapiens]
Length = 2213
Score = 245 bits (626), Expect = 3e-64
Identities = 307/1269 (24%), Positives = 510/1269 (40%), Gaps = 212/1269 (16%)
Query: 12 IGTSETQVDVSNVVPGTRYDITISSISTT----YTSPVTRIVTTNVTKPGPPVFLAGERV 67
+G T V VS + P Y + +++ Y++ +R++ PP +
Sbjct: 721 VGPEMTGVTVSGLTPARTYQFRVCAVNEVGRGQYSAETSRLMLPEEPPSAPPKNIVASGR 780
Query: 68 GSAGILLSWNTPPNP--NGRIISYIVKYKEVCPWMQTVYTQVR-SKPDSLEVLLTNLNPG 124
+ I++ W PP NG + YI++Y+ + Y Q + P+ L+T+L
Sbjct: 781 TNQSIMVQWQPPPETEHNGVLRGYILRYR--LAGLPGEYQQRNITSPEVNYCLVTDLIIW 838
Query: 125 TTYEIKVAAENSAGIGVFSDPFLFQTAESAP-GKVVNLTVEAYNASAVKLIWYLPRQPNG 183
T YEI+VAA N AG+GVFS T + P N+ EA N++ ++ +W P Q
Sbjct: 839 TQYEIQVAAYNGAGLGVFSRAVTEYTLQGVPTAPPQNVQTEAVNSTTIQFLWNPPPQ--- 895
Query: 184 KITSFKISVKHARSGIVVKDVSIRVEDILTGKLPECNENSESFLWSTASP-SPTLGRVTP 242
+ G N+ + W +P + T+ + P
Sbjct: 896 --------------------------QFING----INQGYKLLAWPADAPEAVTVVTIAP 925
Query: 243 PSRTTHSSSTLTQNEISSVWKEPISFVVTHLRPYTTYLFEVSAATTEAGYIDST--IVRT 300
H +T+L+ +T Y V TT ST +V T
Sbjct: 926 DFHGVHHGH------------------ITNLKKFTAYFTSVLCFTTPGDGPPSTPQLVWT 967
Query: 301 PESVPEGPPQNCVTGNITGKSFSILWDPPT----IVTGKFSYRVELYGPSGRILD---NS 353
E P G + I S + W P I+TG + E+YG + L NS
Sbjct: 968 QEDKP-GAVGHLSFTEILDTSLKVSWQEPLEKNGIITG-YQISWEVYGRNDSRLTHTLNS 1025
Query: 354 TKDLKFAFTNLTPFTMYDVYIAAETSAGTG--PKSNISVFTPPDVPGAVFDLQLAEVEST 411
T ++ L+ T Y + +AA T+ GTG S IS PPD+PGA +L ++ +
Sbjct: 1026 TTH-EYKIQGLSSLTTYTIDVAAVTAVGTGLVTSSTISSGVPPDLPGAPSNLVISNISPR 1084
Query: 412 QVRITWKKPRQPNGIINQYRVKVLVPETGIILE-NTLLTGNNE-------------YIND 457
+ ++ I+++ V+ V G E TL NE Y +
Sbjct: 1085 SATLQFRPGYDGKTSISRWIVEGQVGAIGDEEEWVTLYEEENEPDAQMLEIPNLTPYTHY 1144
Query: 458 PMAPEIVNIVEPMVGLYEGSAEMSSDLHS-------------------------LATFIY 492
+ VNIV P Y S+ + L + L Y
Sbjct: 1145 RFRMKQVNIVGP--SPYSPSSRVIQTLQAPPDVAPTSVTVRTASETSLRLRWVPLPDSQY 1202
Query: 493 NSHPDK-NFPARNRAEDQTSPVVTTRNQYITDIAAEQLSYVIRRLVPFTEHMISVSAFTI 551
N +P+ + + D S V Q ++D + + I L + E+ + + AF
Sbjct: 1203 NGNPESVGYRIKYWRSDLQSSAVA---QVVSDRLERE--FTIEELEEWMEYELQMQAFNA 1257
Query: 552 MGEGP-PTVLSVRTRQQVPSSI-KIINYKNISSSSILLYWD--PPEYPNGKITHYTIY-- 605
+G GP V+ RTR+ VPS+ + ++ + +SS+ ILL W P + NG I Y I
Sbjct: 1258 VGAGPWSEVVRGRTRESVPSAAPENVSAEAVSSTQILLTWTSVPEQDQNGLILGYKILFR 1317
Query: 606 AMELDTNRAFQITTIDN--SFLITGLKKYTKYKMRVAASTHVGESSLSEENDIFVRTSED 663
A +LD I ++ S L+ GL+K+ Y+++V A T +G + + I RT +D
Sbjct: 1318 AKDLDPEPRSHIVRGNHTQSALLAGLRKFVLYELQVLAFTRIG-NGVPSTPLILERTKDD 1376
Query: 664 EPESSPQDVEVIDVTADEIRLKWSPPEKPNGIIIAYEVLYK------NIDTLYMKNTSTT 717
P P + +V +R+ W PPE+PNGII+ Y++ Y+ + T +
Sbjct: 1377 AP-GPPVRLVFPEVRLTSVRIVWQPPEEPNGIILGYQIAYRLASSSPHTFTTVEVGATVR 1435
Query: 718 DIILRNLRPHTLYNISVRSYTRFGHGNQVSSLLSVRTSETVPDSAPEN---ITYKNISSG 774
+L P + Y + + TR G G + + +V T+E AP + +++
Sbjct: 1436 QFTATDLAPESAYIFRLSAKTRQGWGEPLEA--TVITTEKRERPAPPRELLVPQAEVTAR 1493
Query: 775 EIELSFLPPSSPNGIIQKYTIYLKRSNGNEERT----INTTSLTQNIKVLKKYTQYIIEV 830
+ L ++P S I+ +T+ ++ E +T I+ + + L+ +T Y + +
Sbjct: 1494 SLRLQWVPGSDGASPIRYFTMQVRELPRGEWQTYSSSISHEATACVVDRLRPFTSYKLRL 1553
Query: 831 SASTLKGEG-VRSAPISILTEEDAPDSPPQDFSVKQLSGVTVKLSWQPPLEP--NGIILY 887
A+ G+ S ++ T +D P PP S + +V + WQPP + NG++
Sbjct: 1554 KATNDIGDSDFSSETEAVTTLQDVPGEPPGSVSATPHTTSSVLIQWQPPRDESLNGLLQG 1613
Query: 888 YTVY--------------------------VWNRSSLKTINVTETS--LELSDLDYNVEY 919
Y +Y + +SS KT+N + TS EL+ L Y
Sbjct: 1614 YRIYYRELEYEAGSGTEAKTLKNPIALHAELTAQSSFKTVNSSSTSTMCELTHLKKYRRY 1673
Query: 920 SAYVTASTRFGDGKTRSNIISFQTPEGAPSDPPKDVYYANLSSSSIILFW--TPPSKPNG 977
+TA G+ + + F E AP+ P++V L++S + + W PP NG
Sbjct: 1674 EVIMTAYNIIGESPASAPVEVF-VGEAAPAMAPQNVQVTPLTASQLEVTWDPPPPESQNG 1732
Query: 978 IIQYYSVYYRNTSGTFMQNFTLHEVTNDFDNMTVSTI------IDKLTIFSYYTFWLTAS 1031
IQ Y +YY + N+ + M V + + LT + Y ++A
Sbjct: 1733 NIQGYKIYYWEA-----------DSQNETEKMKVLFLPEPVVRLKNLTSHTKYLVSISAF 1781
Query: 1032 TSVGNGNKSSDIIEVYTDQDIPEGFVGNLTYESISSTAINVSWVPPAQPNGLVFYYVSLI 1091
+ G+G K SD + T Q P G L + I+ST +NVSW PA NG++ Y +
Sbjct: 1782 NAAGDGPK-SDPQQGRTHQAAP-GAPSFLAFSEITSTTLNVSWGEPAAANGILQGYRVVY 1839
Query: 1092 LQQTPRHVRPPLVT------YERSIYFDNLEKYTDYILKITPSTEKGFSDTYTAQLYIKT 1145
P +VT ++R + +L K Y ++ T TY +L
Sbjct: 1840 EPLAPVQGVSKVVTVEVRGNWQRWLKVRDLTKGVTYFFRVQART-----ITYGPELQANI 1894
Query: 1146 EEDVPETSP 1154
E SP
Sbjct: 1895 TAGPAEGSP 1903
Score = 227 bits (578), Expect = 1e-58
Identities = 270/1167 (23%), Positives = 463/1167 (39%), Gaps = 148/1167 (12%)
Query: 668 SPQDVEVIDVTADE--IRLKWSPPEKPNGIIIAYEVLYKNIDTLYMKNTST-----TDII 720
SPQ++ V ++ + L W P N I+ Y V ++ + + S T +
Sbjct: 670 SPQNLLVSPNSSHSHAVVLSWVRPFDGNSPILYYIVELSENNSPWKVHLSNVGPEMTGVT 729
Query: 721 LRNLRPHTLYNISVRSYTRFGHGNQVSSLLSVRTSETVPDSAPENITYKNISSGEIELSF 780
+ L P Y V + G G + + E P + P+NI ++ I + +
Sbjct: 730 VSGLTPARTYQFRVCAVNEVGRGQYSAETSRLMLPEEPPSAPPKNIVASGRTNQSIMVQW 789
Query: 781 LPP--SSPNGIIQKYTI-YLKRSNGNEERTINTTSLTQN---IKVLKKYTQYIIEVSAST 834
PP + NG+++ Y + Y E + N TS N + L +TQY I+V+A
Sbjct: 790 QPPPETEHNGVLRGYILRYRLAGLPGEYQQRNITSPEVNYCLVTDLIIWTQYEIQVAAYN 849
Query: 835 LKGEGVRSAPISILTEEDAPDSPPQDFSVKQLSGVTVKLSWQPPLEP--NGIILYYTVYV 892
G GV S ++ T + P +PPQ+ + ++ T++ W PP + NGI Y +
Sbjct: 850 GAGLGVFSRAVTEYTLQGVPTAPPQNVQTEAVNSTTIQFLWNPPPQQFINGINQGYKLLA 909
Query: 893 WNRSSLKTINVTETSLELSDLDYNVEYSAYVTASTRFGDGKTRSNIISFQTPEGAPSDPP 952
W + + + V + D++ + ++T +F T +++ F TP P P
Sbjct: 910 WPADAPEAVTVVTIA-----PDFHGVHHGHITNLKKFTAYFT--SVLCFTTPGDGPPSTP 962
Query: 953 KDVY-------------YANLSSSSIILFWTPPSKPNGIIQYY----SVYYRNTSG-TFM 994
+ V+ + + +S+ + W P + NGII Y VY RN S T
Sbjct: 963 QLVWTQEDKPGAVGHLSFTEILDTSLKVSWQEPLEKNGIITGYQISWEVYGRNDSRLTHT 1022
Query: 995 QNFTLHEVTNDFDNMTVSTIIDKLTIFSYYTFWLTASTSVGNGNKSSDIIEVYTDQDIPE 1054
N T HE I L+ + YT + A T+VG G +S I D+P
Sbjct: 1023 LNSTTHEYK-----------IQGLSSLTTYTIDVAAVTAVGTGLVTSSTISSGVPPDLP- 1070
Query: 1055 GFVGNLTYESISSTAINVSWVPPAQPNGLVFYYVSLILQQTPRHVRPPLVTYE------- 1107
G NL +IS + + + P + ++ + YE
Sbjct: 1071 GAPSNLVISNISPRSATLQFRPGYDGKTSISRWIVEGQVGAIGDEEEWVTLYEEENEPDA 1130
Query: 1108 RSIYFDNLEKYTDYILKITPSTEKGFSDTYTAQLYIKTEEDVPETSPIINTFKNLSSTSV 1167
+ + NL YT Y ++ G S + I+T + P+ +P T + S TS+
Sbjct: 1131 QMLEIPNLTPYTHYRFRMKQVNIVGPSPYSPSSRVIQTLQAPPDVAPTSVTVRTASETSL 1190
Query: 1168 LLSW----DPPVKPNGAIISYDLTLQGPNENYSFITS------DNYIILEELSPFTLYSF 1217
L W D N + Y + + S + + +EEL + Y
Sbjct: 1191 RLRWVPLPDSQYNGNPESVGYRIKYWRSDLQSSAVAQVVSDRLEREFTIEELEEWMEYEL 1250
Query: 1218 FAAARTRKGLGP-SSILFFYTDESVPLAPPQNLTLINCTSDFVWLKWS--PSPLPGGIVK 1274
A G GP S ++ T ESVP A P+N++ +S + L W+ P G++
Sbjct: 1251 QMQAFNAVGAGPWSEVVRGRTRESVPSAAPENVSAEAVSSTQILLTWTSVPEQDQNGLIL 1310
Query: 1275 VYSFKIHEHETDTIYYKNI--SGFKTEAKLVGLEPVSTYSIRVSAFTKVGNGNQFSNVVK 1332
Y + D +I A L GL Y ++V AFT++GNG + ++
Sbjct: 1311 GYKILFRAKDLDPEPRSHIVRGNHTQSALLAGLRKFVLYELQVLAFTRIGNGVPSTPLIL 1370
Query: 1333 FTTQESVPDVVQNMQCMATSWQSVLVKWDPPKKANGIITQYMVTVERNST--------KV 1384
T++ P + SV + W PP++ NGII Y + S+ +V
Sbjct: 1371 ERTKDDAPGPPVRLVFPEVRLTSVRIVWQPPEEPNGIILGYQIAYRLASSSPHTFTTVEV 1430
Query: 1385 SPQDHMYTFIKLLANTSYVFKVRASTSAGEGDESTCHVSTLPETVPSVPTN---IAFSDV 1441
+T L ++Y+F++ A T G G+ V T + P + ++V
Sbjct: 1431 GATVRQFTATDLAPESAYIFRLSAKTRQGWGEPLEATVITTEKRERPAPPRELLVPQAEV 1490
Query: 1442 QSTSATLTWIRPD---TILGYFQNYKITTQLRAQKCKEWESEECVEYQKIQYLYEAHLTE 1498
+ S L W+ + + YF T Q+R EW++ Y + ++
Sbjct: 1491 TARSLRLQWVPGSDGASPIRYF-----TMQVRELPRGEWQT------------YSSSISH 1533
Query: 1499 E----TVYGLKKFRWYRFQVAASTNAGYGN-ASNWISTKTLPGPPDGPPENVHVVATSPF 1553
E V L+ F Y+ ++ A+ + G + +S + TL P PP +V +
Sbjct: 1534 EATACVVDRLRPFTSYKLRLKATNDIGDSDFSSETEAVTTLQDVPGEPPGSVSATPHTTS 1593
Query: 1554 SISISWSEP------AVITGPTCYL----------IDVKSVDND---------EFNISFI 1588
S+ I W P ++ G Y + K++ N + + +
Sbjct: 1594 SVLIQWQPPRDESLNGLLQGYRIYYRELEYEAGSGTEAKTLKNPIALHAELTAQSSFKTV 1653
Query: 1589 KSNEENKTIEIKDLEIFTRYSVVITAFTGNISAAYVEGKSSAEMIVTTLESAPKDPPNNM 1648
S+ + E+ L+ + RY V++TA+ NI E +SA + V E+AP P N+
Sbjct: 1654 NSSSTSTMCELTHLKKYRRYEVIMTAY--NIIG---ESPASAPVEVFVGEAAPAMAPQNV 1708
Query: 1649 TFQKIPDEVTKFQLTF--LPPSQPNGNIQVYQALVYREDDPTAVQIHNLSIIQKTNTFVI 1706
Q P ++ ++T+ PP NGNIQ Y+ + D + + + + +
Sbjct: 1709 --QVTPLTASQLEVTWDPPPPESQNGNIQGYKIYYWEADSQNETEKMKVLFLPEP----V 1762
Query: 1707 AMLEGLKGGHTYNISVYAVNSAGAGPK 1733
L+ L Y +S+ A N+AG GPK
Sbjct: 1763 VRLKNLTSHTKYLVSISAFNAAGDGPK 1789
Score = 216 bits (551), Expect = 2e-55
Identities = 312/1343 (23%), Positives = 537/1343 (39%), Gaps = 173/1343 (12%)
Query: 520 YITDIAAEQLSYVIRRLVPFTEHMISVSAFTIMGEGPPTVLSVRTRQQVPSSIKIINYKN 579
+++++ E + L P + V A +G G + + +R +P KN
Sbjct: 717 HLSNVGPEMTGVTVSGLTPARTYQFRVCAVNEVGRGQYSAET--SRLMLPEEPPSAPPKN 774
Query: 580 ISSS-----SILLYWDPPEYPN------GKITHYTIYAMELDTNRAFQITTIDNSFLITG 628
I +S SI++ W PP G I Y + + + + + N L+T
Sbjct: 775 IVASGRTNQSIMVQWQPPPETEHNGVLRGYILRYRLAGLPGEYQQRNITSPEVNYCLVTD 834
Query: 629 LKKYTKYKMRVAASTHVGESSLSEENDIFVRTSEDEPESSPQDVEVIDVTADEIRLKWSP 688
L +T+Y+++VAA G S + T + P + PQ+V+ V + I+ W+P
Sbjct: 835 LIIWTQYEIQVAAYNGAGLGVFSRA--VTEYTLQGVPTAPPQNVQTEAVNSTTIQFLWNP 892
Query: 689 PEKP--NGIIIAYEVLYKNID--------TLYMKNTSTTDIILRNLRPHTLYNISVRSYT 738
P + NGI Y++L D T+ + NL+ T Y SV +T
Sbjct: 893 PPQQFINGINQGYKLLAWPADAPEAVTVVTIAPDFHGVHHGHITNLKKFTAYFTSVLCFT 952
Query: 739 RFGHGNQVSSLLSVRTSETVPDSAPENITYKNISSGEIELSFLPPSSPNGIIQKYTIYLK 798
G G + L V T E P A ++++ I +++S+ P NGII Y I +
Sbjct: 953 TPGDGPPSTPQL-VWTQEDKP-GAVGHLSFTEILDTSLKVSWQEPLEKNGIITGYQISWE 1010
Query: 799 RSNGNEER---TINTTSLTQNIKVLKKYTQYIIEVSASTLKGEG-VRSAPISILTEEDAP 854
N+ R T+N+T+ I+ L T Y I+V+A T G G V S+ IS D P
Sbjct: 1011 VYGRNDSRLTHTLNSTTHEYKIQGLSSLTTYTIDVAAVTAVGTGLVTSSTISSGVPPDLP 1070
Query: 855 DSPPQDFSVKQLSGVTVKLSWQPPLEPNGIILYYTV-----YVWNRSSLKTINVTETS-- 907
+ P + + +S + L ++P + I + V + + T+ E
Sbjct: 1071 GA-PSNLVISNISPRSATLQFRPGYDGKTSISRWIVEGQVGAIGDEEEWVTLYEEENEPD 1129
Query: 908 ---LELSDLDYNVEYSAYVTASTRFGDGKTRSNIISFQTPEGAPSDPPKDVYYANLSSSS 964
LE+ +L Y + G + QT + P P V S +S
Sbjct: 1130 AQMLEIPNLTPYTHYRFRMKQVNIVGPSPYSPSSRVIQTLQAPPDVAPTSVTVRTASETS 1189
Query: 965 IILFWT--PPSKPNG---IIQYYSVYYRNTSGTFMQNFTLHEVTNDFDNMTVSTIIDKLT 1019
+ L W P S+ NG + Y Y+R+ +Q+ + +V + D + I++L
Sbjct: 1190 LRLRWVPLPDSQYNGNPESVGYRIKYWRSD----LQSSAVAQVVS--DRLEREFTIEELE 1243
Query: 1020 IFSYYTFWLTASTSVGNGNKSSDIIEVYTDQDIPEGFVGNLTYESISSTAINVSW--VPP 1077
+ Y + A +VG G S+++ T + +P N++ E++SST I ++W VP
Sbjct: 1244 EWMEYELQMQAFNAVGAG-PWSEVVRGRTRESVPSAAPENVSAEAVSSTQILLTWTSVPE 1302
Query: 1078 AQPNGLVFYYVSLI----LQQTPR-HVRPPLVTYERSIYFDNLEKYTDYILKITPSTEKG 1132
NGL+ Y L L PR H+ + +S L K+ Y L++ T G
Sbjct: 1303 QDQNGLILGYKILFRAKDLDPEPRSHI--VRGNHTQSALLAGLRKFVLYELQVLAFTRIG 1360
Query: 1133 FSDTYTAQLYIKTEEDVPETSPIINTFKNLSSTSVLLSWDPPVKPNGAIISYDLTLQ-GP 1191
T + +T++D P P+ F + TSV + W PP +PNG I+ Y + +
Sbjct: 1361 NGVPSTPLILERTKDDAP-GPPVRLVFPEVRLTSVRIVWQPPEEPNGIILGYQIAYRLAS 1419
Query: 1192 NENYSFITSD-----NYIILEELSPFTLYSFFAAARTRKGLG-PSSILFFYTDESVPLAP 1245
+ ++F T + +L+P + Y F +A+TR+G G P T++ AP
Sbjct: 1420 SSPHTFTTVEVGATVRQFTATDLAPESAYIFRLSAKTRQGWGEPLEATVITTEKRERPAP 1479
Query: 1246 PQNLTL--INCTSDFVWLKWSPSPLPGGIVKVYSFKIHE---HETDTIYYKNISGFKTEA 1300
P+ L + T+ + L+W P ++ ++ ++ E E T Y +IS T
Sbjct: 1480 PRELLVPQAEVTARSLRLQWVPGSDGASPIRYFTMQVRELPRGEWQT-YSSSISHEATAC 1538
Query: 1301 KLVGLEPVSTYSIRVSAFTKVGNGNQFSNVVKFTTQESVP-DVVQNMQCMATSWQSVLVK 1359
+ L P ++Y +R+ A +G+ + S TT + VP + ++ + SVL++
Sbjct: 1539 VVDRLRPFTSYKLRLKATNDIGDSDFSSETEAVTTLQDVPGEPPGSVSATPHTTSSVLIQ 1598
Query: 1360 WDPPK--KANGIITQYMVTVERNSTKVSPQDHMYTF-------IKLLANTSYVFKVRAST 1410
W PP+ NG++ Y + + T +L A +S+ +ST
Sbjct: 1599 WQPPRDESLNGLLQGYRIYYRELEYEAGSGTEAKTLKNPIALHAELTAQSSFKTVNSSST 1658
Query: 1411 SA-----------------------GEGDESTCHVSTLPETVPSV-PTNIAFSDVQSTSA 1446
S GE S + E P++ P N+ + + ++
Sbjct: 1659 STMCELTHLKKYRRYEVIMTAYNIIGESPASAPVEVFVGEAAPAMAPQNVQVTPLTASQL 1718
Query: 1447 TLTW--IRPDTILGYFQNYKITTQLRAQKCKEWESEECVEYQKIQYLYEAHLTEETV--Y 1502
+TW P++ G Q YKI WE++ E +K++ L+ L E V
Sbjct: 1719 EVTWDPPPPESQNGNIQGYKI---------YYWEADSQNETEKMKVLF---LPEPVVRLK 1766
Query: 1503 GLKKFRWYRFQVAASTNAGYGNASNWISTKTLPGPPDGPPENVHVVATSPFSISISWSEP 1562
L Y ++A AG G S+ +T P G P + + ++++SW EP
Sbjct: 1767 NLTSHTKYLVSISAFNAAGDGPKSDPQQGRTHQAAP-GAPSFLAFSEITSTTLNVSWGEP 1825
Query: 1563 AVITG----------PTCYLIDVKSVDNDEFNISFIKSNEENKTIEIKDLEIFTRYSVVI 1612
A G P + V V E ++ N + + ++++DL Y +
Sbjct: 1826 AAANGILQGYRVVYEPLAPVQGVSKVVTVE-----VRGNWQ-RWLKVRDLTKGVTYFFRV 1879
Query: 1613 TAFT--------GNISAAYVEGKSSAEMIVTTLESAPKDPPNNMTFQKIPDEVTKFQLTF 1664
A T NI+A EG + V +SA +LT
Sbjct: 1880 QARTITYGPELQANITAGPAEGSPGSPRDVLVTKSAS-------------------ELTL 1920
Query: 1665 LPPSQPNGNIQVYQALVYREDDPTAVQIHNLSIIQKTNTFVIAMLEGLKGGHTYNISVYA 1724
+G+ ++ + + I ++ T L+ L+ G TY V A
Sbjct: 1921 QWTEGHSGDTPTTGYVIEARPSDEGLWDMFVKDIPRSATSYTLSLDKLRQGVTYEFRVVA 1980
Query: 1725 VNSAGAG-PKVP-MRITMDIKAP 1745
VN AG G P P ++ ++AP
Sbjct: 1981 VNEAGYGEPSNPSTAVSAQVEAP 2003
Score = 134 bits (336), Expect = 1e-30
Identities = 216/992 (21%), Positives = 372/992 (37%), Gaps = 106/992 (10%)
Query: 857 PPQDFSVKQLSGVTVKLSWQPPLEPNGIILYYTVYVWNRSSLKTINVTETSLELSDLDYN 916
PP+D V + G T L +P + Y VW + ++ + + TS + + D +
Sbjct: 579 PPEDHVV--IKGTTATLHCGATHDPRVSLRY----VWKKDNV-ALTPSSTSRIVVEKDGS 631
Query: 917 VEYSAYVTASTRFGD--------GKTRSNIISFQTPEGAPSDPPKDVYYANLSSS-SIIL 967
+ S T S GD G S + + E P P + N S S +++L
Sbjct: 632 LLISQ--TWSGDIGDYSCEIVSEGGNDSRMARLEVIE-LPHSPQNLLVSPNSSHSHAVVL 688
Query: 968 FWTPPSKPNGIIQYYSVYYRNTSGTFMQNFTLHEVTNDFDNMTVSTIIDKLTIFSYYTFW 1027
W P N I YY V + + + L V + +TVS + T Y F
Sbjct: 689 SWVRPFDGNSPILYYIVELSENNSPWKVH--LSNVGPEMTGVTVSGLTPART----YQFR 742
Query: 1028 LTASTSVGNGNKSSDIIEVYTDQDIPEGFVGNLTYESISSTAINVSWVPPAQP--NGLVF 1085
+ A VG G S++ + ++ P N+ ++ +I V W PP + NG++
Sbjct: 743 VCAVNEVGRGQYSAETSRLMLPEEPPSAPPKNIVASGRTNQSIMVQWQPPPETEHNGVLR 802
Query: 1086 YYV------SLILQQTPRHVRPPLVTYERSIYFDNLEKYTDYILKITPSTEKGFSDTYTA 1139
Y+ L + R++ P V Y +L +T Y +++ G ++
Sbjct: 803 GYILRYRLAGLPGEYQQRNITSPEVNY---CLVTDLIIWTQYEIQVAAYNGAGLG-VFSR 858
Query: 1140 QLYIKTEEDVPETSPIINTFKNLSSTSVLLSWDPPVKP--NGAIISYDLTLQGPNENYSF 1197
+ T + VP P + ++ST++ W+PP + NG Y L L P +
Sbjct: 859 AVTEYTLQGVPTAPPQNVQTEAVNSTTIQFLWNPPPQQFINGINQGYKL-LAWPADAPEA 917
Query: 1198 IT---------SDNYIILEELSPFTLYSFFAAARTRKGLGPSSI-LFFYTDESVPLAPPQ 1247
+T ++ + L FT Y T G GP S +T E P A
Sbjct: 918 VTVVTIAPDFHGVHHGHITNLKKFTAYFTSVLCFTTPGDGPPSTPQLVWTQEDKPGAVG- 976
Query: 1248 NLTLINCTSDFVWLKWSPSPLPGGIVKVYSFKIHEH-ETDTIYYKNISGFKTEAKLVGLE 1306
+L+ + + W GI+ Y + D+ ++ E K+ GL
Sbjct: 977 HLSFTEILDTSLKVSWQEPLEKNGIITGYQISWEVYGRNDSRLTHTLNSTTHEYKIQGLS 1036
Query: 1307 PVSTYSIRVSAFTKVGNGNQFSNVVKFTTQESVPDVVQNMQCMATSWQSVLVKWDPPKKA 1366
++TY+I V+A T VG G S+ + +P N+ S +S +++ P
Sbjct: 1037 SLTTYTIDVAAVTAVGTGLVTSSTISSGVPPDLPGAPSNLVISNISPRSATLQFRPGYDG 1096
Query: 1367 NGIITQYMVT------------VERNSTKVSPQDHMYTFIKLLANTSYVFKVRASTSAGE 1414
I++++V V + P M L T Y F+++ G
Sbjct: 1097 KTSISRWIVEGQVGAIGDEEEWVTLYEEENEPDAQMLEIPNLTPYTHYRFRMKQVNIVGP 1156
Query: 1415 G--DESTCHVSTLPETVPSVPTNIAFSDVQSTSATLTWI-RPDTILGYFQNYKITTQLRA 1471
S+ + TL PT++ TS L W+ PD+ Y +
Sbjct: 1157 SPYSPSSRVIQTLQAPPDVAPTSVTVRTASETSLRLRWVPLPDS------QYNGNPESVG 1210
Query: 1472 QKCKEWESEECVEYQKIQYLYEAHLTEE-TVYGLKKFRWYRFQVAASTNAGYGNASNWIS 1530
+ K W S+ ++ + + L E T+ L+++ Y Q+ A G G S +
Sbjct: 1211 YRIKYWRSD--LQSSAVAQVVSDRLEREFTIEELEEWMEYELQMQAFNAVGAGPWSEVVR 1268
Query: 1531 TKTLPGPPDGPPENVHVVATSPFSISISWS------EPAVITGPTCYLIDVKSVDNDEFN 1584
+T P PENV A S I ++W+ + +I G Y I ++ D D
Sbjct: 1269 GRTRESVPSAAPENVSAEAVSSTQILLTWTSVPEQDQNGLILG---YKILFRAKDLDPEP 1325
Query: 1585 ISFIKSNEENKTIEIKDLEIFTRYSVVITAFT--GNISAAYVEGKSSAEMIVTTLESAPK 1642
S I ++ + L F Y + + AFT GN G S +I+ +
Sbjct: 1326 RSHIVRGNHTQSALLAGLRKFVLYELQVLAFTRIGN-------GVPSTPLILERTKDDAP 1378
Query: 1643 DPPNNMTFQKIPDEVTKFQLTFLPPSQPNGNIQVYQALVYREDDPTAVQIHNLSIIQKTN 1702
PP + F ++ +T ++ + PP +PNG I YQ + YR + + +
Sbjct: 1379 GPPVRLVFPEV--RLTSVRIVWQPPEEPNGIILGYQ-IAYRLASSSPHTFTTVEVGATVR 1435
Query: 1703 TFVIAMLEGLKGGHTYNISVYAVNSAGAGPKVPMRITMDIKAPARPKTKPTPIYDATGKL 1762
F L + + + +S G + + T + PA P+ P + T +
Sbjct: 1436 QFTATDL-APESAYIFRLSAKTRQGWGEPLEATVITTEKRERPAPPRELLVPQAEVTAR- 1493
Query: 1763 LVTSTTITIRMPICYYSDDHGPIKNVQVLVTE 1794
++R+ SD PI+ + V E
Sbjct: 1494 -------SLRLQWVPGSDGASPIRYFTMQVRE 1518
Score = 87.8 bits (216), Expect = 1e-16
Identities = 108/462 (23%), Positives = 188/462 (40%), Gaps = 65/462 (14%)
Query: 7 FLLLFIGTSETQVDVSNVVPGTRYDITISSISTT-YTSPV--TRIVTTNVTKPGPP--VF 61
F + +G + Q +++ P + Y +S+ + + P+ T I T +P PP +
Sbjct: 1425 FTTVEVGATVRQFTATDLAPESAYIFRLSAKTRQGWGEPLEATVITTEKRERPAPPRELL 1484
Query: 62 LAGERVGSAGILLSWNTPPNPNGRIISYIVKYKEVCPWMQTVYTQVRSKPDSLEVLLTNL 121
+ V + + L W + I + ++ +E+ Y+ S ++ ++ L
Sbjct: 1485 VPQAEVTARSLRLQWVPGSDGASPIRYFTMQVRELPRGEWQTYSSSISH-EATACVVDRL 1543
Query: 122 NPGTTYEIKVAAENSAGIGVFS-DPFLFQTAESAPGKVV-NLTVEAYNASAVKLIWYLPR 179
P T+Y++++ A N G FS + T + PG+ +++ + S+V + W PR
Sbjct: 1544 RPFTSYKLRLKATNDIGDSDFSSETEAVTTLQDVPGEPPGSVSATPHTTSSVLIQWQPPR 1603
Query: 180 QP--NGKITSFKISVKHARSGIVVKDVSIRVEDILTGKLPECNENSESFLWSTASPSPTL 237
NG + ++I + E S + + +P
Sbjct: 1604 DESLNGLLQGYRIYYREL----------------------EYEAGSGTEAKTLKNPIALH 1641
Query: 238 GRVTPPS--RTTHSSSTLTQNEISSVWKEPISFVVTHLRPYTTYLFEVSAATT--EAGYI 293
+T S +T +SSST T E+ THL+ Y Y ++A E+
Sbjct: 1642 AELTAQSSFKTVNSSSTSTMCEL------------THLKKYRRYEVIMTAYNIIGESPAS 1689
Query: 294 DSTIVRTPESVPEGPPQNCVTGNITGKSFSILWDPPTIVTGKFS---YRVELYGPSGRIL 350
V E+ P PQN +T + WDPP + + Y++ + +
Sbjct: 1690 APVEVFVGEAAPAMAPQNVQVTPLTASQLEVTWDPPPPESQNGNIQGYKIYYWEADSQ-- 1747
Query: 351 DNSTKDLKFAFT--------NLTPFTMYDVYIAAETSAGTGPKSNISVF-TPPDVPGAVF 401
N T+ +K F NLT T Y V I+A +AG GPKS+ T PGA
Sbjct: 1748 -NETEKMKVLFLPEPVVRLKNLTSHTKYLVSISAFNAAGDGPKSDPQQGRTHQAAPGAPS 1806
Query: 402 DLQLAEVESTQVRITWKKPRQPNGIINQYRV--KVLVPETGI 441
L +E+ ST + ++W +P NGI+ YRV + L P G+
Sbjct: 1807 FLAFSEITSTTLNVSWGEPAAANGILQGYRVVYEPLAPVQGV 1848
Score = 77.4 bits (189), Expect = 1e-13
Identities = 133/575 (23%), Positives = 212/575 (36%), Gaps = 110/575 (19%)
Query: 1204 IILEELSPFTLYSFFAAARTRKGLGPSSILFFYTDESVPLAPPQNLTLINCTSD------ 1257
+ +++ +T Y AA T L S+ L + S+ + PP++ +I T+
Sbjct: 543 VFIQDAGNYTCY----AANTEGSLNASATLTVWNRTSI-VHPPEDHVVIKGTTATLHCGA 597
Query: 1258 ---------FVWLKWSPSPLPGGIVKVYSFKIHEHETDTIYYKNISGFKTEAKLVGLEPV 1308
+VW K + + P ++ + E + + + SG +
Sbjct: 598 THDPRVSLRYVWKKDNVALTPSSTSRI----VVEKDGSLLISQTWSG-----------DI 642
Query: 1309 STYSIRVSAFTKVGNGNQFSNVVKFTTQESVPDVVQNMQCMATSWQS--VLVKWDPPKKA 1366
YS + V G S + + E +P QN+ S S V++ W P
Sbjct: 643 GDYSCEI-----VSEGGNDSRMARLEVIE-LPHSPQNLLVSPNSSHSHAVVLSWVRPFDG 696
Query: 1367 NGIITQYMVTVERNST-------KVSPQDHMYTFIKLLANTSYVFKVRASTSAGEGDEST 1419
N I Y+V + N++ V P+ T L +Y F+V A G G S
Sbjct: 697 NSPILYYIVELSENNSPWKVHLSNVGPEMTGVTVSGLTPARTYQFRVCAVNEVGRGQYSA 756
Query: 1420 -CHVSTLPETVPSVPT-NIAFSDVQSTSATLTWIRPD------TILGYFQNYKITTQLRA 1471
LPE PS P NI S + S + W P + GY Y++
Sbjct: 757 ETSRLMLPEEPPSAPPKNIVASGRTNQSIMVQWQPPPETEHNGVLRGYILRYRLAGLPGE 816
Query: 1472 QKCKEWESEECVEYQKIQYLYEAHLTEETVYGLKKFRWYRFQVAASTNAGYGNASNWIST 1531
+ + S E + Y L T Y + QVAA AG G S ++
Sbjct: 817 YQQRNITSPE------VNYCLVTDLIIWTQYEI--------QVAAYNGAGLGVFSRAVTE 862
Query: 1532 KTLPGPPDGPPENVHVVATSPFSISISWSEPAVITGPTCYLIDVKSVDNDEFNISFIKSN 1591
TL G P PP+NV A + +I W+ P P + + ++ +++
Sbjct: 863 YTLQGVPTAPPQNVQTEAVNSTTIQFLWNPP-----PQQF---INGINQGYKLLAWPADA 914
Query: 1592 EENKTI-------------EIKDLEIFTRYSVVITAFTGNISAAYVEGKSSAEMIVTTLE 1638
E T+ I +L+ FT Y + FT +G S +V T E
Sbjct: 915 PEAVTVVTIAPDFHGVHHGHITNLKKFTAYFTSVLCFT-----TPGDGPPSTPQLVWTQE 969
Query: 1639 SAPKDPPNNMTFQKIPDEVTKFQLTFLPPSQPNGNIQVYQAL--VYREDDPTAVQIHNLS 1696
P +++F +I D T ++++ P + NG I YQ VY +D N
Sbjct: 970 DKP-GAVGHLSFTEILD--TSLKVSWQEPLEKNGIITGYQISWEVYGRNDSRLTHTLN-- 1024
Query: 1697 IIQKTNTFVIAMLEGLKGGHTYNISVYAVNSAGAG 1731
T+ + I +GL TY I V AV + G G
Sbjct: 1025 --STTHEYKI---QGLSSLTTYTIDVAAVTAVGTG 1054
Score = 48.9 bits (115), Expect = 6e-05
Identities = 49/197 (24%), Positives = 82/197 (41%), Gaps = 10/197 (5%)
Query: 16 ETQVDVSNVVPGTRYDITISSISTTYTSPVT--RIVTTNVTKPGPPVFLAGERVGSAGIL 73
E V + N+ T+Y ++IS+ + P + + T+ PG P FLA + S +
Sbjct: 1760 EPVVRLKNLTSHTKYLVSISAFNAAGDGPKSDPQQGRTHQAAPGAPSFLAFSEITSTTLN 1819
Query: 74 LSWNTPPNPNGRIISYIVKYKEVCPWM---QTVYTQVRSKPDSLEVLLTNLNPGTTYEIK 130
+SW P NG + Y V Y+ + P + V +VR + + +L G TY +
Sbjct: 1820 VSWGEPAAANGILQGYRVVYEPLAPVQGVSKVVTVEVRGNWQRW-LKVRDLTKGVTYFFR 1878
Query: 131 VAAENSAGIGVFSDPFLFQTAESAPGKVVNLTVEAYNASAVKLIWYLPRQPNGKITSFKI 190
V A AE +PG ++ V +AS + L W + T + I
Sbjct: 1879 VQARTITYGPELQANITAGPAEGSPGSPRDVLV-TKSASELTLQWTEGHSGDTPTTGYVI 1937
Query: 191 SVKHARSGI---VVKDV 204
+ + G+ VKD+
Sbjct: 1938 EARPSDEGLWDMFVKDI 1954
Score = 35.0 bits (79), Expect = 0.85
Identities = 33/145 (22%), Positives = 60/145 (41%), Gaps = 7/145 (4%)
Query: 13 GTSETQVDVSNVVPGTRYDITISSISTTYTSPVTRIVTTNVTK--PGPPVFLAGERVGSA 70
G + + V ++ G Y + + + TY + +T + PG P + + S
Sbjct: 1858 GNWQRWLKVRDLTKGVTYFFRVQARTITYGPELQANITAGPAEGSPGSPRDVLVTKSASE 1917
Query: 71 GILLSWNTPPNPNGRIISYIVKYKEVCPWMQTVYTQ-VRSKPDSLEVLLTNLNPGTTYEI 129
+ L W + + Y+++ + + ++ + + S + L L G TYE
Sbjct: 1918 -LTLQWTEGHSGDTPTTGYVIEARPSDEGLWDMFVKDIPRSATSYTLSLDKLRQGVTYEF 1976
Query: 130 KVAAENSAGIGVFSDPFLFQTAESA 154
+V A N AG G S+P TA SA
Sbjct: 1977 RVVAVNEAGYGEPSNP---STAVSA 1998
>gi|104487297 protein tyrosine phosphatase, receptor type, sigma
isoform 2 precursor [Homo sapiens]
Length = 1910
Score = 241 bits (616), Expect = 5e-63
Identities = 137/361 (37%), Positives = 206/361 (57%), Gaps = 13/361 (3%)
Query: 1944 DAEIIDTKLKLDQLITVADL---ELKDERLTRLLSYRK----SIKPISKKSFLQHVEELC 1996
D++ D++ + L+ ADL KD R ++++ S PI +H E L
Sbjct: 1289 DSKRKDSEPRTKCLLNNADLAPHHPKDPVEMRRINFQTPGMLSHPPIPIADMAEHTERLK 1348
Query: 1997 TNNNLKFQEEFSELPKFLQDLSSTDADLPWNRAKNRFPNIKPYNNNRVKLIADASVPGSD 2056
N++LK +E+ + Q + ++L N+ KNR+ N+ Y+++RV L + GSD
Sbjct: 1349 ANDSLKLSQEYESIDPG-QQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSD 1407
Query: 2057 YINASYISGYLCPNEFIATQGPLPGTVGDFWRMVWETRAKTLVMLTQCFEKGRIRCHQYW 2116
YINA+Y+ GY C N +IATQGPLP T GDFWRMVWE R+ T+VM+T+ EK RI+C QYW
Sbjct: 1408 YINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYW 1467
Query: 2117 PEDNKPVTVFGDIVITKLMEDVQIDWTIRDLKIERHG--DCMTVRQCNFTAWPEHGVPEN 2174
P N+ +G I +T L + +R + ++G + VRQ FTAWP+HGVPE
Sbjct: 1468 P--NRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEY 1525
Query: 2175 SAPLIHFVKLVRASRAHDTTPMIVHCSAGVGRTGVFIALDHLTQHINDHDFVDIYGLVAE 2234
P + F++ V+ D P++VHCSAGVGRTG FI +D + + I VD+YG V
Sbjct: 1526 PTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTL 1585
Query: 2235 LRSERMCMVQNLAQYIFLHQCILDLLSNKGSNQPICFVNYSALQKMDSLDAMEGDVELEW 2294
+RS+R MVQ QY F+H+ +L+ + + P + Y+ +QK+ ++ E +E
Sbjct: 1586 MRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSL-YAYIQKLAQVEPGEHVTGMEL 1644
Query: 2295 E 2295
E
Sbjct: 1645 E 1645
Score = 191 bits (486), Expect = 5e-48
Identities = 106/245 (43%), Positives = 140/245 (57%), Gaps = 6/245 (2%)
Query: 2022 ADLPWNRAKNRFPNIKPYNNNRVKLIADASVPGSDYINASYISGYLCPNEFIATQGPLPG 2081
A+LP N+ KNR NI PY + RV L V GSDYINAS+I GY +IATQGPL
Sbjct: 1662 ANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAE 1721
Query: 2082 TVGDFWRMVWETRAKTLVMLTQCFEKGRIRCHQYWPEDNKPVTVFGDIVITKLMEDVQID 2141
T DFWRM+WE + +VMLT+ E GR +CHQYWP + + V+ + E
Sbjct: 1722 TTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERS--ARYQYFVVDPMAEYNMPQ 1779
Query: 2142 WTIRDLKI--ERHGDCMTVRQCNFTAWPEHGVPENSAPLIHFVKLVRASRAH--DTTPMI 2197
+ +R+ K+ R G TVRQ FT WPE GVP++ I F+ V ++ P+
Sbjct: 1780 YILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPIS 1839
Query: 2198 VHCSAGVGRTGVFIALDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCIL 2257
VHCSAGVGRTGVFI L + + + VDI+ V LR++R MVQ +Y F +Q L
Sbjct: 1840 VHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAAL 1899
Query: 2258 DLLSN 2262
+ L +
Sbjct: 1900 EYLGS 1904
Score = 173 bits (439), Expect = 2e-42
Identities = 188/735 (25%), Positives = 333/735 (45%), Gaps = 71/735 (9%)
Query: 531 YVIRRLVPFTEHMISVSAFTIMGEGPPTVLSV-RTRQQVPSSI-KIINYKNISSSSILLY 588
Y I L P +E+ I VSA +G+GPP+ V RT +Q P+S + + + +S++++++
Sbjct: 374 YSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQ 433
Query: 589 WDPPEYPNGKITHYTI-YAMELDTNRA-FQITTIDNSFLIT--GLKKYTKYKMRVAASTH 644
W+ P PNG I Y + Y ME + +Q +D+S L T L + Y +RV A T
Sbjct: 434 WEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTS 493
Query: 645 VGESSLSEENDIFVRTSEDEPESSPQDVEVIDVTADEIRLKWSPPEKPNGIIIAYEVLYK 704
VG+ LS+ I V+T + P P ++ + I L WSPP + + II YE+L++
Sbjct: 494 VGDGPLSD--PIQVKTQQGVP-GQPMNLRAEARSETSITLSWSPPRQES--IIKYELLFR 548
Query: 705 NID---TLYMKNTSTTDIILRNLRPHTLYNISVRSYTRFGHGNQVSSLLSVRTSETVPDS 761
D + TT ++ +L+P+T Y + + + G G + ++ RT ++ P +
Sbjct: 549 EGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLG-AFTPVVRQRTLQSKPSA 607
Query: 762 APENITYKNISSGEIELSFL--PPSSPNGIIQKYTIYLK--RSNGNEERTIN---TTSLT 814
P+++ ++ S I +S+ PP + NG + Y++ + S E + +N T+
Sbjct: 608 PPQDVKCVSVRSTAILVSWRPPPPETHNGALVGYSVRYRPLGSEDPEPKEVNGIPPTTTQ 667
Query: 815 QNIKVLKKYTQYIIEVSASTLKGEGVRSAPISILTEEDAPDSPPQDFSVKQLSGVTVKLS 874
++ L+K+TQY I A T G G S+P+ + T+ED P +PP+ + L+ +++
Sbjct: 668 ILLEALEKWTQYRITTVAHTEVGPGPESSPVVVRTDEDVPSAPPRKVEAEALNATAIRVL 727
Query: 875 WQPPL--EPNGIILYYTVYVWNRSS--------LKTINVTET-SLELSDLDYNVEYSAYV 923
W+ P +G I Y V+ +K + + + + +++L YS V
Sbjct: 728 WRSPAPGRQHGQIRGYQVHYVRMEGAEARGPPRIKDVMLADAQEMVITNLQPETAYSITV 787
Query: 924 TASTRFGDG-KTRSNIISFQTPEGAPSDPPKDVYYANLSSSSIILFWTPP--SKPNGIIQ 980
A T GDG +++ ++ +GA P + S++ W PP + + ++
Sbjct: 788 AAYTMKGDGARSKPKVV---VTKGAVLGRP-TLSVQQTPEGSLLARWEPPAGTAEDQVLG 843
Query: 981 YYSVYYRNTSGTFMQNFTLHEVTNDFDNMTVSTIIDKLTIFSYYTFWLTASTSVGNGNKS 1040
Y + R S TL E D T S + T Y F L A + G G ++
Sbjct: 844 YRLQFGREDSTPLA---TL-EFPPSEDRYTASGVHKGAT----YVFRLAARSRGGLGEEA 895
Query: 1041 SDIIEVYTDQDIPEGFVGNL-TYESISSTAINVSWVP--PAQPNGLVFYYVSLILQQ--- 1094
++++ + +D P G L + S+ + + W+P PA+ NG + Y + +
Sbjct: 896 AEVLSI--PEDTPRGHPQILEAAGNASAGTVLLRWLPPVPAERNGAIVKYTVAVREAGAL 953
Query: 1095 -TPRHVRPPLVT---YERSIYFDNLEKYTDYILKITPSTEKG---FSDTYTAQLYIKTEE 1147
R P E ++ L+ T Y L++ T +G FS + +++
Sbjct: 954 GPARETELPAAAEPGAENALTLQGLKPDTAYDLQVRAHTRRGPGPFSPPVRYRTFLR--- 1010
Query: 1148 DVPETSPIINTFKNLSSTSVLLSWDPPVKPNGAIISYDLTLQGPNENYSFITSDNYIILE 1207
+ SP K + TSVLLSW+ P N Y + G + T+ ++
Sbjct: 1011 --DQVSPKNFKVKMIMKTSVLLSWEFPDNYNSP-TPYKIQYNGLTLDVDGRTTKK--LIT 1065
Query: 1208 ELSPFTLYSFFAAAR 1222
L P T Y+F R
Sbjct: 1066 HLKPHTFYNFVLTNR 1080
Score = 167 bits (422), Expect = 1e-40
Identities = 183/733 (24%), Positives = 307/733 (41%), Gaps = 66/733 (9%)
Query: 581 SSSSILLYWDPPEYPNGKITHYTIYAMELDTNRAFQITT--IDNSFLITGLKKYTKYKMR 638
+++SI + WD +++Y I + +QI + I GL ++Y++
Sbjct: 331 TATSITITWDSGN--PDPVSYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIW 388
Query: 639 VAASTHVGESSLSEENDIFVRTSEDEPESSPQDVEVIDVTADEIRLKWSPPEKPNGIIIA 698
V+A +G+ SE + RT E P S+P++V+ ++A + ++W P +PNG+I
Sbjct: 389 VSAVNSIGQGPPSES--VVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRG 446
Query: 699 YEVLYKNIDTLYMKNTSTTDI------ILRNLRPHTLYNISVRSYTRFGHGNQVSSLLSV 752
Y V Y + N ++ + +L Y + V ++T G G +S + V
Sbjct: 447 YRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVGDG-PLSDPIQV 505
Query: 753 RTSETVPDSAPENITYKNISSGEIELSFLPPSSPNGIIQKYTIYLKRSNGNEE--RTINT 810
+T + VP P N+ + S I LS+ PP + I KY + + + E RT +
Sbjct: 506 KTQQGVPGQ-PMNLRAEARSETSITLSWSPPRQES--IIKYELLFREGDHGREVGRTFDP 562
Query: 811 TSLTQNIKVLKKYTQYIIEVSASTLKGEGVRSAPISILTEEDAPDSPPQDFSVKQLSGVT 870
T+ + ++ LK T+Y ++A + +G G + + T + P +PPQD +
Sbjct: 563 TT-SYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSKPSAPPQDVKCVSVRSTA 621
Query: 871 VKLSWQPPLEP--NGIILYYTVYVWNRSS-------LKTINVTETSLELSDLDYNVEYSA 921
+ +SW+PP NG ++ Y+V S + I T T + L L+ +Y
Sbjct: 622 ILVSWRPPPPETHNGALVGYSVRYRPLGSEDPEPKEVNGIPPTTTQILLEALEKWTQYRI 681
Query: 922 YVTASTRFGDGKTRSNIISFQTPEGAPSDPPKDVYYANLSSSSIILFWTPPS--KPNGII 979
A T G G S ++ +T E PS PP+ V L++++I + W P+ + +G I
Sbjct: 682 TTVAHTEVGPGPESSPVV-VRTDEDVPSAPPRKVEAEALNATAIRVLWRSPAPGRQHGQI 740
Query: 980 QYYSVYYRNTSGTFMQNFTLHEVTNDFDNMTVSTIIDKLTIFSYYTFWLTASTSVGNGNK 1039
+ Y V+Y G + + D + +I L + Y+ + A T G+G +
Sbjct: 741 RGYQVHYVRMEGAEARGPPRIKDVMLADAQEM--VITNLQPETAYSITVAAYTMKGDGAR 798
Query: 1040 SSDIIEVYTDQDIPEGFVGNLTYESISSTAINVSWVPPAQPNGLVFYYVSLILQQTPRHV 1099
S + V + L+ + ++ W PPA G V Q R
Sbjct: 799 SKPKVVVTKGAVLGR---PTLSVQQTPEGSLLARWEPPA---GTAEDQVLGYRLQFGRED 852
Query: 1100 RPPLVTYERSIYFD-----NLEKYTDYILKITPSTEKGFSDTYTAQLYIKTEEDVPETSP 1154
PL T E D + K Y+ ++ + G + L I ED P P
Sbjct: 853 STPLATLEFPPSEDRYTASGVHKGATYVFRLAARSRGGLGEEAAEVLSI--PEDTPRGHP 910
Query: 1155 -IINTFKNLSSTSVLLSWDPPV--KPNGAIISYDLTLQ-----GPNENYSFIT-----SD 1201
I+ N S+ +VLL W PPV + NGAI+ Y + ++ GP ++
Sbjct: 911 QILEAAGNASAGTVLLRWLPPVPAERNGAIVKYTVAVREAGALGPARETELPAAAEPGAE 970
Query: 1202 NYIILEELSPFTLYSFFAAARTRKGLGPSSILFFYTDESVPLAPPQNLTLINCTSDFVWL 1261
N + L+ L P T Y A TR+G GP S Y P+N + V L
Sbjct: 971 NALTLQGLKPDTAYDLQVRAHTRRGPGPFSPPVRYRTFLRDQVSPKNFKVKMIMKTSVLL 1030
Query: 1262 KW-------SPSP 1267
W SP+P
Sbjct: 1031 SWEFPDNYNSPTP 1043
Score = 166 bits (421), Expect = 2e-40
Identities = 204/802 (25%), Positives = 327/802 (40%), Gaps = 105/802 (13%)
Query: 798 KRSNGNEERTINTTSLTQNIKVLKKYTQYIIEVSASTLKGEGVRSAPISILTEEDAPDSP 857
K +G + + T+ +I L ++Y I VSA G+G S + T E AP S
Sbjct: 357 KSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASA 416
Query: 858 PQDFSVKQLSGVTVKLSWQPPLEPNGIILYYTVYV----------WNRSSLKTINVTETS 907
P++ + LS T+ + W+ P+EPNG+I Y VY W + ++ +T
Sbjct: 417 PRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVG 476
Query: 908 LELSDLDYNVEYSAYVTASTRFGDGKTRSNIISFQTPEGAPSDPPKDVYYANLSSSSIIL 967
L D Y V V A T GDG S+ I +T +G P P ++ S +SI L
Sbjct: 477 SLLEDETYTVR----VLAFTSVGDGPL-SDPIQVKTQQGVPGQ-PMNLRAEARSETSITL 530
Query: 968 FWTPPSKPNGIIQYYSVYYRNTSGTFMQNFTLHEVTNDFDNMTVSTIIDKLTIFSYYTFW 1027
W+PP + II+Y ++ G EV FD T S +++ L + Y F
Sbjct: 531 SWSPP-RQESIIKYELLFREGDHG--------REVGRTFD-PTTSYVVEDLKPNTEYAFR 580
Query: 1028 LTASTSVGNGNKSSDIIEVYTDQDIPEGFVGNLTYESISSTAINVSWVPP---AQPNGLV 1084
L A + G G + ++ T Q P ++ S+ STAI VSW PP LV
Sbjct: 581 LAARSPQGLG-AFTPVVRQRTLQSKPSAPPQDVKCVSVRSTAILVSWRPPPPETHNGALV 639
Query: 1085 FYYVSL----ILQQTPRHVR--PPLVTYERSIYFDNLEKYTDYILKITPSTEKGFSDTYT 1138
Y V P+ V PP T I + LEK+T Y + TE G +
Sbjct: 640 GYSVRYRPLGSEDPEPKEVNGIPPTTT---QILLEALEKWTQYRITTVAHTEVG-PGPES 695
Query: 1139 AQLYIKTEEDVPETSPIINTFKNLSSTSVLLSWDPPV--KPNGAIISYDL--------TL 1188
+ + ++T+EDVP P + L++T++ + W P + +G I Y +
Sbjct: 696 SPVVVRTDEDVPSAPPRKVEAEALNATAIRVLWRSPAPGRQHGQIRGYQVHYVRMEGAEA 755
Query: 1189 QGPNENYSFITSD-NYIILEELSPFTLYSFFAAARTRKGLGPSSILFFYTDESVPLAPPQ 1247
+GP + +D +++ L P T YS AA T KG G S + L P
Sbjct: 756 RGPPRIKDVMLADAQEMVITNLQPETAYSITVAAYTMKGDGARSKPKVVVTKGAVLGRP- 814
Query: 1248 NLTLINCTSDFVWLKWSPSPLPGGIV--KVYSFKIHEHETDTIYYKNISGFKTEAKLV-- 1303
L++ + +W P P G +V +++ D+ + +E +
Sbjct: 815 TLSVQQTPEGSLLARWEP---PAGTAEDQVLGYRLQFGREDSTPLATLEFPPSEDRYTAS 871
Query: 1304 GLEPVSTYSIRVSAFTKVGNGNQFSNVVKF--TTQESVPDVVQNMQCMATSWQSVLVKWD 1361
G+ +TY R++A ++ G G + + V+ T P +++ S +VL++W
Sbjct: 872 GVHKGATYVFRLAARSRGGLGEEAAEVLSIPEDTPRGHPQILE--AAGNASAGTVLLRWL 929
Query: 1362 PPKKA--NGIITQYMVTVERNSTKVSP-------------QDHMYTFIKLLANTSYVFKV 1406
PP A NG I +Y V V R + + P ++ T L +T+Y +V
Sbjct: 930 PPVPAERNGAIVKYTVAV-REAGALGPARETELPAAAEPGAENALTLQGLKPDTAYDLQV 988
Query: 1407 RASTSAGEGDES--TCHVSTLPETVPSVPTNIAFSDVQSTSATLTWIRPDTILGYFQNYK 1464
RA T G G S + + L + V P N + TS L+W PD NY
Sbjct: 989 RAHTRRGPGPFSPPVRYRTFLRDQVS--PKNFKVKMIMKTSVLLSWEFPD-------NYN 1039
Query: 1465 ITTQLRAQKCKEWESEECVEYQKIQYLYEAHLTEETVYGLKKFRWYRFQV---AASTNAG 1521
T + ++Y + + T++ + LK +Y F + +S
Sbjct: 1040 SPTPYK------------IQYNGLTLDVDGRTTKKLITHLKPHTFYNFVLTNRGSSLGGL 1087
Query: 1522 YGNASNWISTKTLPGPPDGPPE 1543
+ W + L G P P+
Sbjct: 1088 QQTVTAWTAFNLLNGKPSVAPK 1109
Score = 160 bits (406), Expect = 1e-38
Identities = 198/814 (24%), Positives = 332/814 (40%), Gaps = 105/814 (12%)
Query: 286 ATTEAGYIDSTIVRTPESVPEGPPQNCVTGNITGKSFSILWD---PPTIVTGKFSYRVEL 342
A + G I++ T +S+P+ P VT N T S +I WD P + Y+ +
Sbjct: 300 AMSSLGVIEAVAQITVKSLPKAPGTPMVTEN-TATSITITWDSGNPDPVSYYVIEYKSKS 358
Query: 343 YGPSGRILDNSTKDLKFAFTNLTPFTMYDVYIAAETSAGTGPKS-NISVFTPPDVPG-AV 400
+I ++ T +++ L+P + Y+++++A S G GP S ++ T P A
Sbjct: 359 QDGPYQIKEDITTT-RYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAP 417
Query: 401 FDLQLAEVESTQVRITWKKPRQPNGIINQYRV-KVLVPETGI------ILENTLLTGNNE 453
++Q + +T + + W++P +PNG+I YRV + PE + ++++LLT
Sbjct: 418 RNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGS 477
Query: 454 YINDPMAPEIVNIVEPMVGLYEGSAEMSSDLHSLATFIYNSHPDKNFPARNRAEDQTSPV 513
+ D V + G +S + P + R A +TS
Sbjct: 478 LLEDE-----TYTVRVLAFTSVGDGPLSDPIQ---VKTQQGVPGQPMNLRAEARSETSIT 529
Query: 514 VTTRNQYITDIAAEQL-------------------SYVIRRLVPFTEHMISVSAFTIMGE 554
++ I +L SYV+ L P TE+ ++A + G
Sbjct: 530 LSWSPPRQESIIKYELLFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGL 589
Query: 555 GPPT-VLSVRTRQQVPSS-IKIINYKNISSSSILLYW--DPPEYPNGKITHYTIYAMEL- 609
G T V+ RT Q PS+ + + ++ S++IL+ W PPE NG + Y++ L
Sbjct: 590 GAFTPVVRQRTLQSKPSAPPQDVKCVSVRSTAILVSWRPPPPETHNGALVGYSVRYRPLG 649
Query: 610 ----DTNRAFQITTIDNSFLITGLKKYTKYKMRVAASTHVGESSLSEENDIFVRTSEDEP 665
+ I L+ L+K+T+Y++ A T VG E + + VRT ED P
Sbjct: 650 SEDPEPKEVNGIPPTTTQILLEALEKWTQYRITTVAHTEVGPG--PESSPVVVRTDEDVP 707
Query: 666 ESSPQDVEVIDVTADEIRLKW-SP-PEKPNGIIIAYEVLYKNIDTLYMKN---------T 714
+ P+ VE + A IR+ W SP P + +G I Y+V Y ++ +
Sbjct: 708 SAPPRKVEAEALNATAIRVLWRSPAPGRQHGQIRGYQVHYVRMEGAEARGPPRIKDVMLA 767
Query: 715 STTDIILRNLRPHTLYNISVRSYTRFGHGNQVSSLLSVRTSETVPDSAPENITYKNISSG 774
++++ NL+P T Y+I+V +YT G G + + V + ++ + G
Sbjct: 768 DAQEMVITNLQPETAYSITVAAYTMKGDGARSKPKVVVTKGAVL---GRPTLSVQQTPEG 824
Query: 775 EIELSFLPPSSPNGIIQKYTIYLKRSNGNEERTINTT------SLTQNIKVLKKYTQYII 828
+ + PP+ G + + + G E+ T T + K Y+
Sbjct: 825 SLLARWEPPA---GTAEDQVLGYRLQFGREDSTPLATLEFPPSEDRYTASGVHKGATYVF 881
Query: 829 EVSASTLKGEGVRSAPISILTEEDAPDSPPQDF-SVKQLSGVTVKLSWQPPL--EPNGII 885
++A + G G +A + + ED P PQ + S TV L W PP+ E NG I
Sbjct: 882 RLAARSRGGLGEEAAEV-LSIPEDTPRGHPQILEAAGNASAGTVLLRWLPPVPAERNGAI 940
Query: 886 LYYTVYVWNRSSLKTINVT----------ETSLELSDLDYNVEYSAYVTASTRFGDGKTR 935
+ YTV V +L T E +L L L + Y V A TR G G
Sbjct: 941 VKYTVAVREAGALGPARETELPAAAEPGAENALTLQGLKPDTAYDLQVRAHTRRGPGPF- 999
Query: 936 SNIISFQTPEGAPSDPPKDVYYANLSSSSIILFWTPPSKPNGIIQYYSVYYRNTSGTFMQ 995
S + ++T PK+ + +S++L W P N Y Y
Sbjct: 1000 SPPVRYRT-FLRDQVSPKNFKVKMIMKTSVLLSWEFPDNYNSPTPYKIQY---------- 1048
Query: 996 NFTLHEVTNDFDNMTVSTIIDKLTIFSYYTFWLT 1029
+ +T D D T +I L ++Y F LT
Sbjct: 1049 ----NGLTLDVDGRTTKKLITHLKPHTFYNFVLT 1078
Score = 147 bits (371), Expect = 1e-34
Identities = 173/664 (26%), Positives = 281/664 (42%), Gaps = 60/664 (9%)
Query: 527 EQLSYVIRRLVPFTEHMISVSAFTIMGEGP-PTVLSVRTRQQVPSSIKIINYKNISSSSI 585
+ L + L+ + + V AFT +G+GP + V+T+Q VP + + S +SI
Sbjct: 469 DSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSI 528
Query: 586 LLYWDPPEYPNGKITHYTIYAMELD----TNRAFQITTIDNSFLITGLKKYTKYKMRVAA 641
L W PP + I Y + E D R F TT S+++ LK T+Y R+AA
Sbjct: 529 TLSWSPPRQES--IIKYELLFREGDHGREVGRTFDPTT---SYVVEDLKPNTEYAFRLAA 583
Query: 642 STHVGESSLSEENDIFVRTSEDEPESSPQDVEVIDVTADEIRLKW--SPPEKPNGIIIAY 699
+ G + + + RT + +P + PQDV+ + V + I + W PPE NG ++ Y
Sbjct: 584 RSPQGLGAFTPV--VRQRTLQSKPSAPPQDVKCVSVRSTAILVSWRPPPPETHNGALVGY 641
Query: 700 EVLYKNIDT-------LYMKNTSTTDIILRNLRPHTLYNISVRSYTRFGHGNQVSSLLSV 752
V Y+ + + + +TT I+L L T Y I+ ++T G G + SS + V
Sbjct: 642 SVRYRPLGSEDPEPKEVNGIPPTTTQILLEALEKWTQYRITTVAHTEVGPGPE-SSPVVV 700
Query: 753 RTSETVPDSAPENITYKNISSGEIELSFLPPS--SPNGIIQKYTIYLKRSNGNEER---- 806
RT E VP + P + + +++ I + + P+ +G I+ Y ++ R G E R
Sbjct: 701 RTDEDVPSAPPRKVEAEALNATAIRVLWRSPAPGRQHGQIRGYQVHYVRMEGAEARGPPR 760
Query: 807 ---TINTTSLTQNIKVLKKYTQYIIEVSASTLKGEGVRSAPISILTEEDAPDSPPQDFSV 863
+ + I L+ T Y I V+A T+KG+G RS P ++T+ P SV
Sbjct: 761 IKDVMLADAQEMVITNLQPETAYSITVAAYTMKGDGARSKPKVVVTKGAVLGRP--TLSV 818
Query: 864 KQLSGVTVKLSWQPPL-EPNGIILYYTVYVWNRSS--LKTINV--TETSLELSDLDYNVE 918
+Q ++ W+PP +L Y + S L T+ +E S +
Sbjct: 819 QQTPEGSLLARWEPPAGTAEDQVLGYRLQFGREDSTPLATLEFPPSEDRYTASGVHKGAT 878
Query: 919 YSAYVTASTRFGDGKTRSNIISFQTPEGAPSDPPKDVYYA-NLSSSSIILFWTP--PSKP 975
Y + A +R G G+ + ++S PE P P+ + A N S+ +++L W P P++
Sbjct: 879 YVFRLAARSRGGLGEEAAEVLSI--PEDTPRGHPQILEAAGNASAGTVLLRWLPPVPAER 936
Query: 976 NGIIQYYSVYYRNTSGTFMQNFTLHEVTNDFDNMTVSTIIDKLTIFSYYTFWLTASTSVG 1035
NG I Y+V R T + T + L + Y + A T G
Sbjct: 937 NGAIVKYTVAVREAGALGPARETELPAAAEPGAENALT-LQGLKPDTAYDLQVRAHTRRG 995
Query: 1036 NGNKSSDI--IEVYTDQDIPEGFVGNLTYESISSTAINVSWVPPAQPNGLVFY---YVSL 1090
G S + DQ P+ N + I T++ +SW P N Y Y L
Sbjct: 996 PGPFSPPVRYRTFLRDQVSPK----NFKVKMIMKTSVLLSWEFPDNYNSPTPYKIQYNGL 1051
Query: 1091 ILQQTPRHVRPPLVTYERSIYFDNLEKYTDYILKITPSTEKGFSDTYTAQLYIKTEEDVP 1150
L R + L+T+ + F N ++L S+ G T TA P
Sbjct: 1052 TLDVDGRTTK-KLITHLKPHTFYN------FVLTNRGSSLGGLQQTVTAWTAFNLLNGKP 1104
Query: 1151 ETSP 1154
+P
Sbjct: 1105 SVAP 1108
Score = 111 bits (278), Expect = 7e-24
Identities = 123/522 (23%), Positives = 209/522 (40%), Gaps = 48/522 (9%)
Query: 1237 TDESVPLAPPQNLTLINCTSDFV--WLKWSPSPLPGGIVKVYSFKIHEHETDTIYYKNIS 1294
T +S+P AP + N + W +P P V Y + D Y
Sbjct: 314 TVKSLPKAPGTPMVTENTATSITITWDSGNPDP-----VSYYVIEYKSKSQDGPYQIKED 368
Query: 1295 GFKTEAKLVGLEPVSTYSIRVSAFTKVGNGNQFSNVVKFTTQESVPDVVQNMQCMATSWQ 1354
T + GL P S Y I VSA +G G +VV T +++ +N+Q S
Sbjct: 369 ITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSAT 428
Query: 1355 SVLVKWDPPKKANGIITQYMV--TVER-----NSTKVSPQDHMYTFI-KLLANTSYVFKV 1406
+++V+W+ P + NG+I Y V T+E N K + D + T + LL + +Y +V
Sbjct: 429 TMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRV 488
Query: 1407 RASTSAGEGDESTCHVSTLPETVPSVPTNIAFSDVQSTSATLTWIRP--DTILGYFQNYK 1464
A TS G+G S + VP P N+ TS TL+W P ++I+ Y
Sbjct: 489 LAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPRQESIIKY----- 543
Query: 1465 ITTQLRAQKCKEWESEECVEYQKIQYLYEAHLTEETVYGLKKFRWYRFQVAASTNAGYGN 1524
E E +++ ++ T V LK Y F++AA + G G
Sbjct: 544 -----------ELLFREGDHGREVGRTFDP-TTSYVVEDLKPNTEYAFRLAARSPQGLGA 591
Query: 1525 ASNWISTKTLPGPPDGPPENVHVVATSPFSISISWSEP------AVITGPTCYLIDVKSV 1578
+ + +TL P PP++V V+ +I +SW P + G + + S
Sbjct: 592 FTPVVRQRTLQSKPSAPPQDVKCVSVRSTAILVSWRPPPPETHNGALVGYSVRYRPLGSE 651
Query: 1579 DNDEFNISFIKSNEENKTIEIKDLEIFTRYSVVITAFTGNISAAYVEGKSSAEMIVTTLE 1638
D + ++ I I ++ LE +T+Y + A T G S+ ++V T E
Sbjct: 652 DPEPKEVNGIPPT--TTQILLEALEKWTQYRITTVAHT-----EVGPGPESSPVVVRTDE 704
Query: 1639 SAPKDPPNNMTFQKIPDEVTKFQLTFLPPSQPNGNIQVYQALVYREDDPTAVQIHNLSII 1698
P PP + + + + P + +G I+ YQ R + A + +
Sbjct: 705 DVPSAPPRKVEAEALNATAIRVLWRSPAPGRQHGQIRGYQVHYVRMEGAEARGPPRIKDV 764
Query: 1699 QKTNTFVIAMLEGLKGGHTYNISVYAVNSAGAGPKVPMRITM 1740
+ + ++ L+ Y+I+V A G G + ++ +
Sbjct: 765 MLADAQEM-VITNLQPETAYSITVAAYTMKGDGARSKPKVVV 805
Score = 105 bits (261), Expect = 7e-22
Identities = 163/721 (22%), Positives = 264/721 (36%), Gaps = 121/721 (16%)
Query: 17 TQVDVSNVVPGTRYDITISSISTTYTSPVTRIVTTNVTKPGP---PVFLAGERVGSAGIL 73
T+ + + P + Y+I +S++++ P + V T + P P + + + ++
Sbjct: 372 TRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMI 431
Query: 74 LSWNTPPNPNGRIISYIVKYKEVCPWMQTVYTQVRSKPDSLEVLLTNLNPGTTYEIKVAA 133
+ W P PNG I Y V Y + P Q + DSL + +L TY ++V A
Sbjct: 432 VQWEEPVEPNGLIRGYRVYYT-MEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLA 490
Query: 134 ENSAGIGVFSDPFLFQTAESAPGKVVNLTVEAYNASAVKLIWYLPRQPNGKITSFKISVK 193
S G G SDP +T + PG+ +NL EA + +++ L W PRQ + I +++ +
Sbjct: 491 FTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPRQES--IIKYELLFR 548
Query: 194 HARSGIVVKDVSIRVEDILTGKLPECNENSESFLWSTASPSPT-LGRVTP--PSRTTHSS 250
G V R D T + E + + + + A+ SP LG TP RT S
Sbjct: 549 EGDHGREVG----RTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSK 604
Query: 251 STLTQNEISSV----------WKEP---------ISFVVTH---------------LRPY 276
+ ++ V W+ P + + V + + P
Sbjct: 605 PSAPPQDVKCVSVRSTAILVSWRPPPPETHNGALVGYSVRYRPLGSEDPEPKEVNGIPPT 664
Query: 277 TTYLF-----------EVSAATTEAG---YIDSTIVRTPESVPEGPPQNCVTGNITGKSF 322
TT + + A TE G +VRT E VP PP+ + +
Sbjct: 665 TTQILLEALEKWTQYRITTVAHTEVGPGPESSPVVVRTDEDVPSAPPRKVEAEALNATAI 724
Query: 323 SILWDPPT------IVTGKFSYRVELYGPSG----RILDNSTKDL-KFAFTNLTPFTMYD 371
+LW P + G + V + G RI D D + TNL P T Y
Sbjct: 725 RVLWRSPAPGRQHGQIRGYQVHYVRMEGAEARGPPRIKDVMLADAQEMVITNLQPETAYS 784
Query: 372 VYIAAETSAGTGPKSNISVFTPPDVPGAVFDLQLAEVEST---QVRITWKKPR-QPNGII 427
+ +AA T G G +S V GAV V+ T + W+ P +
Sbjct: 785 ITVAAYTMKGDGARSKPKVVV---TKGAVLGRPTLSVQQTPEGSLLARWEPPAGTAEDQV 841
Query: 428 NQYRVKVLVPETGIILENTLLTGNNEYINDPMAPEIVNIVEPMVGLYEGSAEMSSDLHSL 487
YR++ ++ + + Y + + G E ++++ S+
Sbjct: 842 LGYRLQFGREDSTPLATLEFPPSEDRYTASGVHKGATYVFRLAARSRGGLGEEAAEVLSI 901
Query: 488 ATFIYNSHPDKNFPARNRAEDQT-----SPVVTTRNQYI------------------TDI 524
HP A N + PV RN I T++
Sbjct: 902 PEDTPRGHPQILEAAGNASAGTVLLRWLPPVPAERNGAIVKYTVAVREAGALGPARETEL 961
Query: 525 AA-----EQLSYVIRRLVPFTEHMISVSAFTIMGEG---PPTVLSVRTRQQV-PSSIKII 575
A + + ++ L P T + + V A T G G PP R QV P + K+
Sbjct: 962 PAAAEPGAENALTLQGLKPDTAYDLQVRAHTRRGPGPFSPPVRYRTFLRDQVSPKNFKV- 1020
Query: 576 NYKNISSSSILLYWDPPEYPNGKITHYTIY-AMELDTNRAFQITTIDNSFLITGLKKYTK 634
K I +S+LL W+ P+ N + Y + LD + LIT LK +T
Sbjct: 1021 --KMIMKTSVLLSWEFPDNYNSPTPYKIQYNGLTLDVDGR------TTKKLITHLKPHTF 1072
Query: 635 Y 635
Y
Sbjct: 1073 Y 1073
Score = 95.1 bits (235), Expect = 7e-19
Identities = 182/807 (22%), Positives = 310/807 (38%), Gaps = 141/807 (17%)
Query: 45 VTRIVTTNVTK-PGPPVFLAGERVGSAGILLSWNTP-PNPNGRIISYIVKYKEVCPWMQT 102
V +I ++ K PG P+ + I ++W++ P+P + Y+++YK Q
Sbjct: 310 VAQITVKSLPKAPGTPMVTENT---ATSITITWDSGNPDP---VSYYVIEYKSKS---QD 360
Query: 103 VYTQVRSKPDSLEVLLTNLNPGTTYEIKVAAENSAGIGVFSDPFLFQTAESAPGKVVNLT 162
Q++ + + L+P + YEI V+A NS G G S+ + +T E AP
Sbjct: 361 GPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAP------- 413
Query: 163 VEAYNASAVKLIWYLPRQPNGKITSFKISVKHARSGIVVKDVSIRVEDILTGKLPECNEN 222
ASA PR ++ S A + IV + + ++ G
Sbjct: 414 -----ASA-------PRNVQARMLS-------ATTMIVQWEEPVEPNGLIRGYR------ 448
Query: 223 SESFLWSTASPSPTLGRVTPPSRTTHSSSTLTQNEISSVWKEPISFVVTHLRPYTTYLFE 282
++ T P +G + S LT V L TY
Sbjct: 449 ----VYYTMEPEHPVGNW---QKHNVDDSLLT--------------TVGSLLEDETYTVR 487
Query: 283 VSAATT--EAGYIDSTIVRTPESVPEGPPQNCVTGNITGKSFSILWDPP---TIVTGKFS 337
V A T+ + D V+T + VP G P N + S ++ W PP +I+ +
Sbjct: 488 VLAFTSVGDGPLSDPIQVKTQQGVP-GQPMNLRAEARSETSITLSWSPPRQESIIKYELL 546
Query: 338 YRVELYGPS-GRILDNSTKDLKFAFTNLTPFTMYDVYIAAETSAGTGPKSNI----SVFT 392
+R +G GR D +T + +L P T Y +AA + G G + + ++ +
Sbjct: 547 FREGDHGREVGRTFDPTTS---YVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQS 603
Query: 393 PPDVPGAVFDLQLAEVESTQVRITWKKP--RQPNGIINQYRVKV---------------L 435
P P D++ V ST + ++W+ P NG + Y V+ +
Sbjct: 604 KPSAPPQ--DVKCVSVRSTAILVSWRPPPPETHNGALVGYSVRYRPLGSEDPEPKEVNGI 661
Query: 436 VPETGIILENTL---------LTGNNEYINDP-MAPEIVNIVEPMVGLYEGSAEMSSDLH 485
P T IL L + E P +P +V E + E + L+
Sbjct: 662 PPTTTQILLEALEKWTQYRITTVAHTEVGPGPESSPVVVRTDEDVPSAPPRKVEAEA-LN 720
Query: 486 SLATFIYNSHPDKNFPARNRAEDQTSPVVTTRNQ--------YITDIA-AEQLSYVIRRL 536
+ A + P P R + + V R + I D+ A+ VI L
Sbjct: 721 ATAIRVLWRSPA---PGRQHGQIRGYQVHYVRMEGAEARGPPRIKDVMLADAQEMVITNL 777
Query: 537 VPFTEHMISVSAFTIMGEGPPTVLSVRTRQQVPSSIKIINYKNISSSSILLYWDPPE-YP 595
P T + I+V+A+T+ G+G + V + ++ + S+L W+PP
Sbjct: 778 QPETAYSITVAAYTMKGDGARSKPKVVVTKGAVLGRPTLSVQQTPEGSLLARWEPPAGTA 837
Query: 596 NGKITHYTIYAMELDTN--RAFQITTIDNSFLITGLKKYTKYKMRVAASTHVGESSLSEE 653
++ Y + D+ + ++ + +G+ K Y R+AA + G L EE
Sbjct: 838 EDQVLGYRLQFGREDSTPLATLEFPPSEDRYTASGVHKGATYVFRLAARSRGG---LGEE 894
Query: 654 NDIFVRTSEDEPESSPQDVEVI-DVTADEIRLKWSP--PEKPNGIIIAYEVLYKNIDTL- 709
+ ED P PQ +E + +A + L+W P P + NG I+ Y V + L
Sbjct: 895 AAEVLSIPEDTPRGHPQILEAAGNASAGTVLLRWLPPVPAERNGAIVKYTVAVREAGALG 954
Query: 710 ---------YMKNTSTTDIILRNLRPHTLYNISVRSYTRFGHGNQVSSLLSVRTSETVPD 760
+ + + L+ L+P T Y++ VR++TR G G S + RT
Sbjct: 955 PARETELPAAAEPGAENALTLQGLKPDTAYDLQVRAHTRRGPG-PFSPPVRYRTF-LRDQ 1012
Query: 761 SAPENITYKNISSGEIELSFLPPSSPN 787
+P+N K I + LS+ P + N
Sbjct: 1013 VSPKNFKVKMIMKTSVLLSWEFPDNYN 1039
Score = 54.7 bits (130), Expect = 1e-06
Identities = 95/420 (22%), Positives = 166/420 (39%), Gaps = 54/420 (12%)
Query: 1335 TQESVPDVVQNMQCMATSWQSVLVKWDPPKKANGIITQYMVTVERNSTKVSPQDHMYTFI 1394
+ E +P N+ C+A VKW + A + + + V RN ++ T +
Sbjct: 240 SHEIMPGGNVNITCVAVGSPMPYVKW--MQGAEDLTPEDDMPVGRNVLEL-------TDV 290
Query: 1395 KLLANTSYVFKVRASTSAGEGDESTCHVSTLPETVPSVPTNIAFSDVQSTSATLTWI--R 1452
K AN + V A +S G E+ ++ +++P P ++ +TS T+TW
Sbjct: 291 KDSANYTCV----AMSSLGV-IEAVAQITV--KSLPKAPGTPMVTENTATSITITWDSGN 343
Query: 1453 PDTILGYFQNYKITTQLRAQKCKEWESEECVEYQKIQYLYEAHLTEETVYGLKKFRWYRF 1512
PD + Y YK +Q + KE + T ++ GL Y
Sbjct: 344 PDPVSYYVIEYKSKSQDGPYQIKE----------------DITTTRYSIGGLSPNSEYEI 387
Query: 1513 QVAASTNAGYGNASNWISTKTLPGPPDGPPENVHVVATSPFSISISWSEPAVITGPTCYL 1572
V+A + G G S + T+T P P NV S ++ + W EP G
Sbjct: 388 WVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGY 447
Query: 1573 IDVKSVDNDEFNISFIKSNEENKTI-EIKDLEIFTRYSVVITAFTGNISAAYVEGKSSAE 1631
+++ + ++ K N ++ + + L Y+V + AFT + +G S
Sbjct: 448 RVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFT-----SVGDGPLSDP 502
Query: 1632 MIVTTLESAPKDPPNNMTFQKIPDEVTKFQLTFLPPSQPNGNIQVYQALVYREDDPTAVQ 1691
+ V T + P P N + +T L++ PP Q +I Y+ L++RE D
Sbjct: 503 IQVKTQQGVPGQPMNLRAEARSETSIT---LSWSPPRQE--SIIKYE-LLFREGD----- 551
Query: 1692 IHNLSIIQKTNTFVIAMLEGLKGGHTYNISVYAVNSAGAGPKVPM--RITMDIKAPARPK 1749
H + + + ++E LK Y + A + G G P+ + T+ K A P+
Sbjct: 552 -HGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSKPSAPPQ 610
Score = 53.9 bits (128), Expect = 2e-06
Identities = 96/443 (21%), Positives = 160/443 (36%), Gaps = 94/443 (21%)
Query: 12 IGTSETQVDVSNVVPGTRYDITISSISTTYTSPVTR--IVTTNVTKPG-PPVFLAGERVG 68
I + TQ+ + + T+Y IT + + P + +V T+ P PP + E +
Sbjct: 661 IPPTTTQILLEALEKWTQYRITTVAHTEVGPGPESSPVVVRTDEDVPSAPPRKVEAEALN 720
Query: 69 SAGILLSWNTPP--NPNGRIISYIVKYKEVCPWMQTVYTQVRSKP--------DSLEVLL 118
+ I + W +P +G+I Y V Y ++ + R P D+ E+++
Sbjct: 721 ATAIRVLWRSPAPGRQHGQIRGYQVHY------VRMEGAEARGPPRIKDVMLADAQEMVI 774
Query: 119 TNLNPGTTYEIKVAAENSAGIGVFSDPFLFQTAESAPGKVVNLTVEAYNASAVKLIWYLP 178
TNL P T Y I VAA G G S P + T + G+ L+V+ ++ W P
Sbjct: 775 TNLQPETAYSITVAAYTMKGDGARSKPKVVVTKGAVLGR-PTLSVQQTPEGSLLARWEPP 833
Query: 179 RQPNGKITSFKISVKHARSGIVVKDVSIRVEDILTGKLPECNENSESFLWSTASPSPTLG 238
+ +L +L E+S +P TL
Sbjct: 834 -------------------------AGTAEDQVLGYRLQFGREDS--------TPLATL- 859
Query: 239 RVTPPSRTTHSSSTLTQNEISSVWKEPISFVVTHLRPYTTYLFEVSAATTEA-GYIDSTI 297
PPS +++S + + TY+F ++A + G + +
Sbjct: 860 -EFPPSEDRYTASGVHKG--------------------ATYVFRLAARSRGGLGEEAAEV 898
Query: 298 VRTPESVPEGPPQNC-VTGNITGKSFSILWDPPTIVTG-----KFSYRVELYGPSGRILD 351
+ PE P G PQ GN + + + W PP K++ V G G +
Sbjct: 899 LSIPEDTPRGHPQILEAAGNASAGTVLLRWLPPVPAERNGAIVKYTVAVREAGALGPARE 958
Query: 352 NST-------KDLKFAFTNLTPFTMYDVYIAAETSAGTGPKS---NISVFTPPDVPGAVF 401
+ L P T YD+ + A T G GP S F V F
Sbjct: 959 TELPAAAEPGAENALTLQGLKPDTAYDLQVRAHTRRGPGPFSPPVRYRTFLRDQVSPKNF 1018
Query: 402 DLQLAEVESTQVRITWKKPRQPN 424
+++ + T V ++W+ P N
Sbjct: 1019 KVKM--IMKTSVLLSWEFPDNYN 1039
>gi|104487006 protein tyrosine phosphatase, receptor type, sigma
isoform 1 precursor [Homo sapiens]
Length = 1948
Score = 241 bits (615), Expect = 6e-63
Identities = 127/316 (40%), Positives = 186/316 (58%), Gaps = 6/316 (1%)
Query: 1982 PISKKSFLQHVEELCTNNNLKFQEEFSELPKFLQDLSSTDADLPWNRAKNRFPNIKPYNN 2041
PI +H E L N++LK +E+ + Q + ++L N+ KNR+ N+ Y++
Sbjct: 1372 PIPIADMAEHTERLKANDSLKLSQEYESIDPG-QQFTWEHSNLEVNKPKNRYANVIAYDH 1430
Query: 2042 NRVKLIADASVPGSDYINASYISGYLCPNEFIATQGPLPGTVGDFWRMVWETRAKTLVML 2101
+RV L + GSDYINA+Y+ GY C N +IATQGPLP T GDFWRMVWE R+ T+VM+
Sbjct: 1431 SRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMM 1490
Query: 2102 TQCFEKGRIRCHQYWPEDNKPVTVFGDIVITKLMEDVQIDWTIRDLKIERHG--DCMTVR 2159
T+ EK RI+C QYWP N+ +G I +T L + +R + ++G + VR
Sbjct: 1491 TRLEEKSRIKCDQYWP--NRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVR 1548
Query: 2160 QCNFTAWPEHGVPENSAPLIHFVKLVRASRAHDTTPMIVHCSAGVGRTGVFIALDHLTQH 2219
Q FTAWP+HGVPE P + F++ V+ D P++VHCSAGVGRTG FI +D + +
Sbjct: 1549 QFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLER 1608
Query: 2220 INDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLLSNKGSNQPICFVNYSALQK 2279
I VD+YG V +RS+R MVQ QY F+H+ +L+ + + P + Y+ +QK
Sbjct: 1609 IKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSL-YAYIQK 1667
Query: 2280 MDSLDAMEGDVELEWE 2295
+ ++ E +E E
Sbjct: 1668 LAQVEPGEHVTGMELE 1683
Score = 191 bits (486), Expect = 5e-48
Identities = 106/245 (43%), Positives = 140/245 (57%), Gaps = 6/245 (2%)
Query: 2022 ADLPWNRAKNRFPNIKPYNNNRVKLIADASVPGSDYINASYISGYLCPNEFIATQGPLPG 2081
A+LP N+ KNR NI PY + RV L V GSDYINAS+I GY +IATQGPL
Sbjct: 1700 ANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAE 1759
Query: 2082 TVGDFWRMVWETRAKTLVMLTQCFEKGRIRCHQYWPEDNKPVTVFGDIVITKLMEDVQID 2141
T DFWRM+WE + +VMLT+ E GR +CHQYWP + + V+ + E
Sbjct: 1760 TTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERS--ARYQYFVVDPMAEYNMPQ 1817
Query: 2142 WTIRDLKI--ERHGDCMTVRQCNFTAWPEHGVPENSAPLIHFVKLVRASRAH--DTTPMI 2197
+ +R+ K+ R G TVRQ FT WPE GVP++ I F+ V ++ P+
Sbjct: 1818 YILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPIS 1877
Query: 2198 VHCSAGVGRTGVFIALDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCIL 2257
VHCSAGVGRTGVFI L + + + VDI+ V LR++R MVQ +Y F +Q L
Sbjct: 1878 VHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAAL 1937
Query: 2258 DLLSN 2262
+ L +
Sbjct: 1938 EYLGS 1942
Score = 172 bits (437), Expect = 3e-42
Identities = 189/744 (25%), Positives = 334/744 (44%), Gaps = 80/744 (10%)
Query: 531 YVIRRLVPFTEHMISVSAFTIMGEGPPTVLSV-RTRQQVPSSI-KIINYKNISSSSILLY 588
Y I L P +E+ I VSA +G+GPP+ V RT +Q P+S + + + +S++++++
Sbjct: 387 YSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQ 446
Query: 589 WDPPEYPNGKITHYTI-YAMELDTNRA-FQITTIDNSFLIT--GLKKYTKYKMRVAASTH 644
W+ P PNG I Y + Y ME + +Q +D+S L T L + Y +RV A T
Sbjct: 447 WEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTS 506
Query: 645 VGESSLSEENDIFVRTSEDEPESSPQDVEVIDVTADEIRLKWSPPEKPNGIIIAYEVLYK 704
VG+ LS+ I V+T + P P ++ + I L WSPP + + II YE+L++
Sbjct: 507 VGDGPLSD--PIQVKTQQGVP-GQPMNLRAEARSETSITLSWSPPRQES--IIKYELLFR 561
Query: 705 NID---TLYMKNTSTTDIILRNLRPHTLYNISVRSYTRFGHGNQVSSLLSVRTSETVPDS 761
D + TT ++ +L+P+T Y + + + G G + ++ RT ++ P +
Sbjct: 562 EGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLG-AFTPVVRQRTLQSKPSA 620
Query: 762 APENITYKNISSGEIELSFL--PPSSPNGIIQKYTIYLK--RSNGNEERTIN---TTSLT 814
P+++ ++ S I +S+ PP + NG + Y++ + S E + +N T+
Sbjct: 621 PPQDVKCVSVRSTAILVSWRPPPPETHNGALVGYSVRYRPLGSEDPEPKEVNGIPPTTTQ 680
Query: 815 QNIKVLKKYTQYIIEVSASTLKGEGVRSAPISILTEEDAPDSPPQDFSVKQLSGVTVKLS 874
++ L+K+TQY I A T G G S+P+ + T+ED P +PP+ + L+ +++
Sbjct: 681 ILLEALEKWTQYRITTVAHTEVGPGPESSPVVVRTDEDVPSAPPRKVEAEALNATAIRVL 740
Query: 875 WQPPL--EPNGIILYYTVY------------------VWNRSSLKTINVTETSLELSDLD 914
W+ P +G I Y V+ + + +T + E + +++L
Sbjct: 741 WRSPAPGRQHGQIRGYQVHYVRMEGAEARGPPRIKDVMLADAQWETDDTAEYEMVITNLQ 800
Query: 915 YNVEYSAYVTASTRFGDG-KTRSNIISFQTPEGAPSDPPKDVYYANLSSSSIILFWTPP- 972
YS V A T GDG +++ ++ +GA P + S++ W PP
Sbjct: 801 PETAYSITVAAYTMKGDGARSKPKVV---VTKGAVLGRP-TLSVQQTPEGSLLARWEPPA 856
Query: 973 -SKPNGIIQYYSVYYRNTSGTFMQNFTLHEVTNDFDNMTVSTIIDKLTIFSYYTFWLTAS 1031
+ + ++ Y + R S TL E D T S + T Y F L A
Sbjct: 857 GTAEDQVLGYRLQFGREDSTPLA---TL-EFPPSEDRYTASGVHKGAT----YVFRLAAR 908
Query: 1032 TSVGNGNKSSDIIEVYTDQDIPEGFVGNL-TYESISSTAINVSWVP--PAQPNGLVFYYV 1088
+ G G ++++++ + +D P G L + S+ + + W+P PA+ NG + Y
Sbjct: 909 SRGGLGEEAAEVLSI--PEDTPRGHPQILEAAGNASAGTVLLRWLPPVPAERNGAIVKYT 966
Query: 1089 SLILQQ----TPRHVRPPLVT---YERSIYFDNLEKYTDYILKITPSTEKG---FSDTYT 1138
+ + R P E ++ L+ T Y L++ T +G FS
Sbjct: 967 VAVREAGALGPARETELPAAAEPGAENALTLQGLKPDTAYDLQVRAHTRRGPGPFSPPVR 1026
Query: 1139 AQLYIKTEEDVPETSPIINTFKNLSSTSVLLSWDPPVKPNGAIISYDLTLQGPNENYSFI 1198
+ +++ + SP K + TSVLLSW+ P N Y + G +
Sbjct: 1027 YRTFLR-----DQVSPKNFKVKMIMKTSVLLSWEFPDNYNSP-TPYKIQYNGLTLDVDGR 1080
Query: 1199 TSDNYIILEELSPFTLYSFFAAAR 1222
T+ ++ L P T Y+F R
Sbjct: 1081 TTKK--LITHLKPHTFYNFVLTNR 1102
Score = 168 bits (426), Expect = 5e-41
Identities = 184/740 (24%), Positives = 311/740 (42%), Gaps = 71/740 (9%)
Query: 581 SSSSILLYWDPPEYPNGKITHYTIYAMELDTNRAFQITT--IDNSFLITGLKKYTKYKMR 638
+++SI + WD +++Y I + +QI + I GL ++Y++
Sbjct: 344 TATSITITWDSGN--PDPVSYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIW 401
Query: 639 VAASTHVGESSLSEENDIFVRTSEDEPESSPQDVEVIDVTADEIRLKWSPPEKPNGIIIA 698
V+A +G+ SE + RT E P S+P++V+ ++A + ++W P +PNG+I
Sbjct: 402 VSAVNSIGQGPPSES--VVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRG 459
Query: 699 YEVLYKNIDTLYMKNTSTTDI------ILRNLRPHTLYNISVRSYTRFGHGNQVSSLLSV 752
Y V Y + N ++ + +L Y + V ++T G G +S + V
Sbjct: 460 YRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVGDG-PLSDPIQV 518
Query: 753 RTSETVPDSAPENITYKNISSGEIELSFLPPSSPNGIIQKYTIYLKRSNGNEE--RTINT 810
+T + VP P N+ + S I LS+ PP + I KY + + + E RT +
Sbjct: 519 KTQQGVPGQ-PMNLRAEARSETSITLSWSPPRQES--IIKYELLFREGDHGREVGRTFDP 575
Query: 811 TSLTQNIKVLKKYTQYIIEVSASTLKGEGVRSAPISILTEEDAPDSPPQDFSVKQLSGVT 870
T+ + ++ LK T+Y ++A + +G G + + T + P +PPQD +
Sbjct: 576 TT-SYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSKPSAPPQDVKCVSVRSTA 634
Query: 871 VKLSWQPPLEP--NGIILYYTVYVWNRSS-------LKTINVTETSLELSDLDYNVEYSA 921
+ +SW+PP NG ++ Y+V S + I T T + L L+ +Y
Sbjct: 635 ILVSWRPPPPETHNGALVGYSVRYRPLGSEDPEPKEVNGIPPTTTQILLEALEKWTQYRI 694
Query: 922 YVTASTRFGDGKTRSNIISFQTPEGAPSDPPKDVYYANLSSSSIILFWTPPS--KPNGII 979
A T G G S ++ +T E PS PP+ V L++++I + W P+ + +G I
Sbjct: 695 TTVAHTEVGPGPESSPVV-VRTDEDVPSAPPRKVEAEALNATAIRVLWRSPAPGRQHGQI 753
Query: 980 QYYSVYYRNTSGT------FMQNFTLHEVTNDFDNMT-VSTIIDKLTIFSYYTFWLTAST 1032
+ Y V+Y G +++ L + + D+ +I L + Y+ + A T
Sbjct: 754 RGYQVHYVRMEGAEARGPPRIKDVMLADAQWETDDTAEYEMVITNLQPETAYSITVAAYT 813
Query: 1033 SVGNGNKSSDIIEVYTDQDIPEGFVGNLTYESISSTAINVSWVPPAQPNGLVFYYVSLIL 1092
G+G +S + V + L+ + ++ W PPA G V
Sbjct: 814 MKGDGARSKPKVVVTKGAVLGR---PTLSVQQTPEGSLLARWEPPA---GTAEDQVLGYR 867
Query: 1093 QQTPRHVRPPLVTYERSIYFD-----NLEKYTDYILKITPSTEKGFSDTYTAQLYIKTEE 1147
Q R PL T E D + K Y+ ++ + G + L I E
Sbjct: 868 LQFGREDSTPLATLEFPPSEDRYTASGVHKGATYVFRLAARSRGGLGEEAAEVLSI--PE 925
Query: 1148 DVPETSP-IINTFKNLSSTSVLLSWDPPV--KPNGAIISYDLTLQ-----GPNENYSFIT 1199
D P P I+ N S+ +VLL W PPV + NGAI+ Y + ++ GP
Sbjct: 926 DTPRGHPQILEAAGNASAGTVLLRWLPPVPAERNGAIVKYTVAVREAGALGPARETELPA 985
Query: 1200 -----SDNYIILEELSPFTLYSFFAAARTRKGLGPSSILFFYTDESVPLAPPQNLTLINC 1254
++N + L+ L P T Y A TR+G GP S Y P+N +
Sbjct: 986 AAEPGAENALTLQGLKPDTAYDLQVRAHTRRGPGPFSPPVRYRTFLRDQVSPKNFKVKMI 1045
Query: 1255 TSDFVWLKW-------SPSP 1267
V L W SP+P
Sbjct: 1046 MKTSVLLSWEFPDNYNSPTP 1065
Score = 163 bits (412), Expect = 2e-39
Identities = 204/811 (25%), Positives = 328/811 (40%), Gaps = 114/811 (14%)
Query: 798 KRSNGNEERTINTTSLTQNIKVLKKYTQYIIEVSASTLKGEGVRSAPISILTEEDAPDSP 857
K +G + + T+ +I L ++Y I VSA G+G S + T E AP S
Sbjct: 370 KSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASA 429
Query: 858 PQDFSVKQLSGVTVKLSWQPPLEPNGIILYYTVYV----------WNRSSLKTINVTETS 907
P++ + LS T+ + W+ P+EPNG+I Y VY W + ++ +T
Sbjct: 430 PRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVG 489
Query: 908 LELSDLDYNVEYSAYVTASTRFGDGKTRSNIISFQTPEGAPSDPPKDVYYANLSSSSIIL 967
L D Y V V A T GDG S+ I +T +G P P ++ S +SI L
Sbjct: 490 SLLEDETYTVR----VLAFTSVGDGPL-SDPIQVKTQQGVPGQ-PMNLRAEARSETSITL 543
Query: 968 FWTPPSKPNGIIQYYSVYYRNTSGTFMQNFTLHEVTNDFDNMTVSTIIDKLTIFSYYTFW 1027
W+PP + II+Y ++ G EV FD T S +++ L + Y F
Sbjct: 544 SWSPP-RQESIIKYELLFREGDHG--------REVGRTFD-PTTSYVVEDLKPNTEYAFR 593
Query: 1028 LTASTSVGNGNKSSDIIEVYTDQDIPEGFVGNLTYESISSTAINVSWVPP---AQPNGLV 1084
L A + G G + ++ T Q P ++ S+ STAI VSW PP LV
Sbjct: 594 LAARSPQGLG-AFTPVVRQRTLQSKPSAPPQDVKCVSVRSTAILVSWRPPPPETHNGALV 652
Query: 1085 FYYVSL----ILQQTPRHVR--PPLVTYERSIYFDNLEKYTDYILKITPSTEKGFSDTYT 1138
Y V P+ V PP T I + LEK+T Y + TE G +
Sbjct: 653 GYSVRYRPLGSEDPEPKEVNGIPPTTT---QILLEALEKWTQYRITTVAHTEVG-PGPES 708
Query: 1139 AQLYIKTEEDVPETSPIINTFKNLSSTSVLLSWDPPV--KPNGAIISYDL--------TL 1188
+ + ++T+EDVP P + L++T++ + W P + +G I Y +
Sbjct: 709 SPVVVRTDEDVPSAPPRKVEAEALNATAIRVLWRSPAPGRQHGQIRGYQVHYVRMEGAEA 768
Query: 1189 QGPNENYSFI----------TSDNYIILEELSPFTLYSFFAAARTRKGLGPSSILFFYTD 1238
+GP + T++ +++ L P T YS AA T KG G S
Sbjct: 769 RGPPRIKDVMLADAQWETDDTAEYEMVITNLQPETAYSITVAAYTMKGDGARSKPKVVVT 828
Query: 1239 ESVPLAPPQNLTLINCTSDFVWLKWSPSPLPGGIV--KVYSFKIHEHETDTIYYKNISGF 1296
+ L P L++ + +W P P G +V +++ D+ +
Sbjct: 829 KGAVLGRP-TLSVQQTPEGSLLARWEP---PAGTAEDQVLGYRLQFGREDSTPLATLEFP 884
Query: 1297 KTEAKLV--GLEPVSTYSIRVSAFTKVGNGNQFSNVVKF--TTQESVPDVVQNMQCMATS 1352
+E + G+ +TY R++A ++ G G + + V+ T P +++ S
Sbjct: 885 PSEDRYTASGVHKGATYVFRLAARSRGGLGEEAAEVLSIPEDTPRGHPQILE--AAGNAS 942
Query: 1353 WQSVLVKWDPPKKA--NGIITQYMVTVERNSTKVSP-------------QDHMYTFIKLL 1397
+VL++W PP A NG I +Y V V R + + P ++ T L
Sbjct: 943 AGTVLLRWLPPVPAERNGAIVKYTVAV-REAGALGPARETELPAAAEPGAENALTLQGLK 1001
Query: 1398 ANTSYVFKVRASTSAGEGDES--TCHVSTLPETVPSVPTNIAFSDVQSTSATLTWIRPDT 1455
+T+Y +VRA T G G S + + L + V P N + TS L+W PD
Sbjct: 1002 PDTAYDLQVRAHTRRGPGPFSPPVRYRTFLRDQVS--PKNFKVKMIMKTSVLLSWEFPD- 1058
Query: 1456 ILGYFQNYKITTQLRAQKCKEWESEECVEYQKIQYLYEAHLTEETVYGLKKFRWYRFQV- 1514
NY T + ++Y + + T++ + LK +Y F +
Sbjct: 1059 ------NYNSPTPYK------------IQYNGLTLDVDGRTTKKLITHLKPHTFYNFVLT 1100
Query: 1515 --AASTNAGYGNASNWISTKTLPGPPDGPPE 1543
+S + W + L G P P+
Sbjct: 1101 NRGSSLGGLQQTVTAWTAFNLLNGKPSVAPK 1131
Score = 159 bits (402), Expect = 3e-38
Identities = 199/823 (24%), Positives = 335/823 (40%), Gaps = 114/823 (13%)
Query: 286 ATTEAGYIDSTIVRTPESVPEGPPQNCVTGNITGKSFSILWD---PPTIVTGKFSYRVEL 342
A + G I++ T +S+P+ P VT N T S +I WD P + Y+ +
Sbjct: 313 AMSSLGVIEAVAQITVKSLPKAPGTPMVTEN-TATSITITWDSGNPDPVSYYVIEYKSKS 371
Query: 343 YGPSGRILDNSTKDLKFAFTNLTPFTMYDVYIAAETSAGTGPKS-NISVFTPPDVPG-AV 400
+I ++ T +++ L+P + Y+++++A S G GP S ++ T P A
Sbjct: 372 QDGPYQIKEDITTT-RYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAP 430
Query: 401 FDLQLAEVESTQVRITWKKPRQPNGIINQYRV-KVLVPETGI------ILENTLLTGNNE 453
++Q + +T + + W++P +PNG+I YRV + PE + ++++LLT
Sbjct: 431 RNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGS 490
Query: 454 YINDPMAPEIVNIVEPMVGLYEGSAEMSSDLHSLATFIYNSHPDKNFPARNRAEDQTSPV 513
+ D V + G +S + P + R A +TS
Sbjct: 491 LLEDE-----TYTVRVLAFTSVGDGPLSDPIQ---VKTQQGVPGQPMNLRAEARSETSIT 542
Query: 514 VTTRNQYITDIAAEQL-------------------SYVIRRLVPFTEHMISVSAFTIMGE 554
++ I +L SYV+ L P TE+ ++A + G
Sbjct: 543 LSWSPPRQESIIKYELLFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGL 602
Query: 555 GPPT-VLSVRTRQQVPSS-IKIINYKNISSSSILLYW--DPPEYPNGKITHYTIYAMEL- 609
G T V+ RT Q PS+ + + ++ S++IL+ W PPE NG + Y++ L
Sbjct: 603 GAFTPVVRQRTLQSKPSAPPQDVKCVSVRSTAILVSWRPPPPETHNGALVGYSVRYRPLG 662
Query: 610 ----DTNRAFQITTIDNSFLITGLKKYTKYKMRVAASTHVGESSLSEENDIFVRTSEDEP 665
+ I L+ L+K+T+Y++ A T VG E + + VRT ED P
Sbjct: 663 SEDPEPKEVNGIPPTTTQILLEALEKWTQYRITTVAHTEVGPG--PESSPVVVRTDEDVP 720
Query: 666 ESSPQDVEVIDVTADEIRLKW-SP-PEKPNGIIIAYEVLYKNIDTLYMK----------- 712
+ P+ VE + A IR+ W SP P + +G I Y+V Y ++ +
Sbjct: 721 SAPPRKVEAEALNATAIRVLWRSPAPGRQHGQIRGYQVHYVRMEGAEARGPPRIKDVMLA 780
Query: 713 -------NTSTTDIILRNLRPHTLYNISVRSYTRFGHGNQVSSLLSVRTSETVPDSAPEN 765
+T+ ++++ NL+P T Y+I+V +YT G G + + V +
Sbjct: 781 DAQWETDDTAEYEMVITNLQPETAYSITVAAYTMKGDGARSKPKVVVTKGAVL---GRPT 837
Query: 766 ITYKNISSGEIELSFLPPSSPNGIIQKYTIYLKRSNGNEERTINTT------SLTQNIKV 819
++ + G + + PP+ G + + + G E+ T T
Sbjct: 838 LSVQQTPEGSLLARWEPPA---GTAEDQVLGYRLQFGREDSTPLATLEFPPSEDRYTASG 894
Query: 820 LKKYTQYIIEVSASTLKGEGVRSAPISILTEEDAPDSPPQDF-SVKQLSGVTVKLSWQPP 878
+ K Y+ ++A + G G +A + + ED P PQ + S TV L W PP
Sbjct: 895 VHKGATYVFRLAARSRGGLGEEAAEV-LSIPEDTPRGHPQILEAAGNASAGTVLLRWLPP 953
Query: 879 L--EPNGIILYYTVYVWNRSSLKTINVT----------ETSLELSDLDYNVEYSAYVTAS 926
+ E NG I+ YTV V +L T E +L L L + Y V A
Sbjct: 954 VPAERNGAIVKYTVAVREAGALGPARETELPAAAEPGAENALTLQGLKPDTAYDLQVRAH 1013
Query: 927 TRFGDGKTRSNIISFQTPEGAPSDPPKDVYYANLSSSSIILFWTPPSKPNGIIQYYSVYY 986
TR G G S + ++T PK+ + +S++L W P N Y Y
Sbjct: 1014 TRRGPGPF-SPPVRYRT-FLRDQVSPKNFKVKMIMKTSVLLSWEFPDNYNSPTPYKIQY- 1070
Query: 987 RNTSGTFMQNFTLHEVTNDFDNMTVSTIIDKLTIFSYYTFWLT 1029
+ +T D D T +I L ++Y F LT
Sbjct: 1071 -------------NGLTLDVDGRTTKKLITHLKPHTFYNFVLT 1100
Score = 148 bits (373), Expect = 7e-35
Identities = 175/673 (26%), Positives = 282/673 (41%), Gaps = 69/673 (10%)
Query: 527 EQLSYVIRRLVPFTEHMISVSAFTIMGEGP-PTVLSVRTRQQVPSSIKIINYKNISSSSI 585
+ L + L+ + + V AFT +G+GP + V+T+Q VP + + S +SI
Sbjct: 482 DSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSI 541
Query: 586 LLYWDPPEYPNGKITHYTIYAMELD----TNRAFQITTIDNSFLITGLKKYTKYKMRVAA 641
L W PP + I Y + E D R F TT S+++ LK T+Y R+AA
Sbjct: 542 TLSWSPPRQES--IIKYELLFREGDHGREVGRTFDPTT---SYVVEDLKPNTEYAFRLAA 596
Query: 642 STHVGESSLSEENDIFVRTSEDEPESSPQDVEVIDVTADEIRLKW--SPPEKPNGIIIAY 699
+ G + + + RT + +P + PQDV+ + V + I + W PPE NG ++ Y
Sbjct: 597 RSPQGLGAFTPV--VRQRTLQSKPSAPPQDVKCVSVRSTAILVSWRPPPPETHNGALVGY 654
Query: 700 EVLYKNIDT-------LYMKNTSTTDIILRNLRPHTLYNISVRSYTRFGHGNQVSSLLSV 752
V Y+ + + + +TT I+L L T Y I+ ++T G G + SS + V
Sbjct: 655 SVRYRPLGSEDPEPKEVNGIPPTTTQILLEALEKWTQYRITTVAHTEVGPGPE-SSPVVV 713
Query: 753 RTSETVPDSAPENITYKNISSGEIELSFLPPS--SPNGIIQKYTIYLKRSNGNEER---- 806
RT E VP + P + + +++ I + + P+ +G I+ Y ++ R G E R
Sbjct: 714 RTDEDVPSAPPRKVEAEALNATAIRVLWRSPAPGRQHGQIRGYQVHYVRMEGAEARGPPR 773
Query: 807 ------------TINTTSLTQNIKVLKKYTQYIIEVSASTLKGEGVRSAPISILTEEDAP 854
T +T I L+ T Y I V+A T+KG+G RS P ++T+
Sbjct: 774 IKDVMLADAQWETDDTAEYEMVITNLQPETAYSITVAAYTMKGDGARSKPKVVVTKGAVL 833
Query: 855 DSPPQDFSVKQLSGVTVKLSWQPPL-EPNGIILYYTVYVWNRSS--LKTINV--TETSLE 909
P SV+Q ++ W+PP +L Y + S L T+ +E
Sbjct: 834 GRP--TLSVQQTPEGSLLARWEPPAGTAEDQVLGYRLQFGREDSTPLATLEFPPSEDRYT 891
Query: 910 LSDLDYNVEYSAYVTASTRFGDGKTRSNIISFQTPEGAPSDPPKDVYYA-NLSSSSIILF 968
S + Y + A +R G G+ + ++S PE P P+ + A N S+ +++L
Sbjct: 892 ASGVHKGATYVFRLAARSRGGLGEEAAEVLSI--PEDTPRGHPQILEAAGNASAGTVLLR 949
Query: 969 WTP--PSKPNGIIQYYSVYYRNTSGTFMQNFTLHEVTNDFDNMTVSTIIDKLTIFSYYTF 1026
W P P++ NG I Y+V R T + T + L + Y
Sbjct: 950 WLPPVPAERNGAIVKYTVAVREAGALGPARETELPAAAEPGAENALT-LQGLKPDTAYDL 1008
Query: 1027 WLTASTSVGNGNKSSDI--IEVYTDQDIPEGFVGNLTYESISSTAINVSWVPPAQPNGLV 1084
+ A T G G S + DQ P+ N + I T++ +SW P N
Sbjct: 1009 QVRAHTRRGPGPFSPPVRYRTFLRDQVSPK----NFKVKMIMKTSVLLSWEFPDNYNSPT 1064
Query: 1085 FY---YVSLILQQTPRHVRPPLVTYERSIYFDNLEKYTDYILKITPSTEKGFSDTYTAQL 1141
Y Y L L R + L+T+ + F N ++L S+ G T TA
Sbjct: 1065 PYKIQYNGLTLDVDGRTTK-KLITHLKPHTFYN------FVLTNRGSSLGGLQQTVTAWT 1117
Query: 1142 YIKTEEDVPETSP 1154
P +P
Sbjct: 1118 AFNLLNGKPSVAP 1130
Score = 110 bits (274), Expect = 2e-23
Identities = 116/471 (24%), Positives = 189/471 (40%), Gaps = 47/471 (9%)
Query: 1237 TDESVPLAPPQNLTLINCTSDFV--WLKWSPSPLPGGIVKVYSFKIHEHETDTIYYKNIS 1294
T +S+P AP + N + W +P P V Y + D Y
Sbjct: 327 TVKSLPKAPGTPMVTENTATSITITWDSGNPDP-----VSYYVIEYKSKSQDGPYQIKED 381
Query: 1295 GFKTEAKLVGLEPVSTYSIRVSAFTKVGNGNQFSNVVKFTTQESVPDVVQNMQCMATSWQ 1354
T + GL P S Y I VSA +G G +VV T +++ +N+Q S
Sbjct: 382 ITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSAT 441
Query: 1355 SVLVKWDPPKKANGIITQYMV--TVER-----NSTKVSPQDHMYTFI-KLLANTSYVFKV 1406
+++V+W+ P + NG+I Y V T+E N K + D + T + LL + +Y +V
Sbjct: 442 TMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRV 501
Query: 1407 RASTSAGEGDESTCHVSTLPETVPSVPTNIAFSDVQSTSATLTWIRP--DTILGYFQNYK 1464
A TS G+G S + VP P N+ TS TL+W P ++I+ Y
Sbjct: 502 LAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPRQESIIKY----- 556
Query: 1465 ITTQLRAQKCKEWESEECVEYQKIQYLYEAHLTEETVYGLKKFRWYRFQVAASTNAGYGN 1524
E E +++ ++ T V LK Y F++AA + G G
Sbjct: 557 -----------ELLFREGDHGREVGRTFDP-TTSYVVEDLKPNTEYAFRLAARSPQGLGA 604
Query: 1525 ASNWISTKTLPGPPDGPPENVHVVATSPFSISISWSEP------AVITGPTCYLIDVKSV 1578
+ + +TL P PP++V V+ +I +SW P + G + + S
Sbjct: 605 FTPVVRQRTLQSKPSAPPQDVKCVSVRSTAILVSWRPPPPETHNGALVGYSVRYRPLGSE 664
Query: 1579 DNDEFNISFIKSNEENKTIEIKDLEIFTRYSVVITAFTGNISAAYVEGKSSAEMIVTTLE 1638
D + ++ I I ++ LE +T+Y + A T G S+ ++V T E
Sbjct: 665 DPEPKEVNGIPPT--TTQILLEALEKWTQYRITTVAHT-----EVGPGPESSPVVVRTDE 717
Query: 1639 SAPKDPPNNMTFQKIPDEVTKFQLTFLPPSQPNGNIQVYQALVYREDDPTA 1689
P PP + + + + P + +G I+ YQ R + A
Sbjct: 718 DVPSAPPRKVEAEALNATAIRVLWRSPAPGRQHGQIRGYQVHYVRMEGAEA 768
Score = 108 bits (271), Expect = 5e-23
Identities = 186/850 (21%), Positives = 330/850 (38%), Gaps = 108/850 (12%)
Query: 213 TGKLPECNENSESFLWSTASPSPTLGRVTPPSRTTHSSSTLTQNEISSVWKEPISFVVTH 272
T + E S + W + +P P V + + +I++ + +
Sbjct: 337 TPMVTENTATSITITWDSGNPDPVSYYVIEYKSKSQDGPYQIKEDITTT-----RYSIGG 391
Query: 273 LRPYTTYLFEVSAATT--EAGYIDSTIVRTPESVPEGPPQNCVTGNITGKSFSILWDPPT 330
L P + Y VSA + + +S + RT E P P+N ++ + + W+ P
Sbjct: 392 LSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPV 451
Query: 331 IVTG-----KFSYRVELYGPSGRILDNSTKD-LKFAFTNLTPFTMYDVYIAAETSAGTGP 384
G + Y +E P G ++ D L +L Y V + A TS G GP
Sbjct: 452 EPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVGDGP 511
Query: 385 KSN-ISVFTPPDVPGAVFDLQLAEVESTQVRITWKKPRQPNGIINQYRV----------- 432
S+ I V T VPG +L+ T + ++W PRQ + I +Y +
Sbjct: 512 LSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPRQES--IIKYELLFREGDHGREV 569
Query: 433 -KVLVPETGIILENTLLTGNNEYINDPMA--PEIVNIVEPMVGLYEGSAEMSS------- 482
+ P T ++E+ L N EY A P+ + P+V ++ S+
Sbjct: 570 GRTFDPTTSYVVED--LKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSKPSAPPQDVKC 627
Query: 483 -DLHSLATFIYNSHPDK--------NFPARNRAEDQTSPVVTTRNQYITDIAAEQLSYVI 533
+ S A + P + R R P + + I ++
Sbjct: 628 VSVRSTAILVSWRPPPPETHNGALVGYSVRYRPLGSEDP----EPKEVNGIPPTTTQILL 683
Query: 534 RRLVPFTEHMISVSAFTIMGEGP-PTVLSVRTRQQVPSS-IKIINYKNISSSSILLYW-- 589
L +T++ I+ A T +G GP + + VRT + VPS+ + + + +++++I + W
Sbjct: 684 EALEKWTQYRITTVAHTEVGPGPESSPVVVRTDEDVPSAPPRKVEAEALNATAIRVLWRS 743
Query: 590 DPPEYPNGKITHYTIYAMELDTNRA-------------FQITTIDNS---FLITGLKKYT 633
P +G+I Y ++ + ++ A Q T D + +IT L+ T
Sbjct: 744 PAPGRQHGQIRGYQVHYVRMEGAEARGPPRIKDVMLADAQWETDDTAEYEMVITNLQPET 803
Query: 634 KYKMRVAASTHVGESSLSEENDIFVRTSE-DEPESSPQDVEVIDVTADEIRLKWSPPE-K 691
Y + VAA T G+ + S+ + + + P S Q + A +W PP
Sbjct: 804 AYSITVAAYTMKGDGARSKPKVVVTKGAVLGRPTLSVQQTPEGSLLA-----RWEPPAGT 858
Query: 692 PNGIIIAYEVLYKNIDTLYMKN----TSTTDIILRNLRPHTLYNISVRSYTRFGHGNQVS 747
++ Y + + D+ + S + Y + + +R G G + +
Sbjct: 859 AEDQVLGYRLQFGREDSTPLATLEFPPSEDRYTASGVHKGATYVFRLAARSRGGLGEEAA 918
Query: 748 SLLSVRTSETVPDSAPENI-TYKNISSGEIELSFLP--PSSPNGIIQKYTIYLKRSNG-N 803
+LS+ E P P+ + N S+G + L +LP P+ NG I KYT+ ++ +
Sbjct: 919 EVLSI--PEDTPRGHPQILEAAGNASAGTVLLRWLPPVPAERNGAIVKYTVAVREAGALG 976
Query: 804 EERTINTTSLTQ-------NIKVLKKYTQYIIEVSASTLKGEGVRSAPISILTEEDAPDS 856
R + + ++ LK T Y ++V A T +G G S P+ T S
Sbjct: 977 PARETELPAAAEPGAENALTLQGLKPDTAYDLQVRAHTRRGPGPFSPPVRYRTFLRDQVS 1036
Query: 857 PPQDFSVKQLSGVTVKLSWQPPLEPNGIILYYTVYVWNRSSLKTINVTETSLELSDLDYN 916
P++F VK + +V LSW+ P N Y Y N +L T L ++ L +
Sbjct: 1037 -PKNFKVKMIMKTSVLLSWEFPDNYNSPTPYKIQY--NGLTLDVDGRTTKKL-ITHLKPH 1092
Query: 917 VEYSAYVT--ASTRFGDGKTRSNIISFQTPEGAPSDPPKDVYYANLSSSSIILFWTPPSK 974
Y+ +T S+ G +T + +F G PS PK + I+ + P +
Sbjct: 1093 TFYNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSVAPKP------DADGFIMVYLPDGQ 1146
Query: 975 PNGIIQYYSV 984
+Q Y +
Sbjct: 1147 SPVPVQSYFI 1156
Score = 106 bits (265), Expect = 2e-22
Identities = 193/880 (21%), Positives = 343/880 (38%), Gaps = 154/880 (17%)
Query: 45 VTRIVTTNVTK-PGPPVFLAGERVGSAGILLSWNTP-PNPNGRIISYIVKYKEVCPWMQT 102
V +I ++ K PG P+ + I ++W++ P+P + Y+++YK Q
Sbjct: 323 VAQITVKSLPKAPGTPMVTENT---ATSITITWDSGNPDP---VSYYVIEYKSKS---QD 373
Query: 103 VYTQVRSKPDSLEVLLTNLNPGTTYEIKVAAENSAGIGVFSDPFLFQTAESAPGKVV-NL 161
Q++ + + L+P + YEI V+A NS G G S+ + +T E AP N+
Sbjct: 374 GPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNV 433
Query: 162 TVEAYNASAVKLIWYLPRQPNGKITSFKISVKHARSGIVVKDVSIRVEDILTGKLPECNE 221
+A+ + + W P +PNG I +++ V V+D L + E
Sbjct: 434 QARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLE 493
Query: 222 NSESFLWSTASPSPTLGRVTPPSRT------------------THSSSTLTQN------- 256
+ + A S G ++ P + + +S TL+ +
Sbjct: 494 DETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPRQESI 553
Query: 257 --------------EISSVWKEPISFVVTHLRPYTTYLFEVSAATTEAGYIDSTIV--RT 300
E+ + S+VV L+P T Y F ++A + + + +V RT
Sbjct: 554 IKYELLFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRT 613
Query: 301 PESVPEGPPQNCVTGNITGKSFSILWDPPTIVT---GKFSYRVELYGPSGRILDNSTKDL 357
+S P PPQ+ ++ + + W PP T Y V Y P G D K++
Sbjct: 614 LQSKPSAPPQDVKCVSVRSTAILVSWRPPPPETHNGALVGYSVR-YRPLGS-EDPEPKEV 671
Query: 358 --------KFAFTNLTPFTMYDVYIAAETSAGTGPKSN-ISVFTPPDVPGA-VFDLQLAE 407
+ L +T Y + A T G GP+S+ + V T DVP A ++
Sbjct: 672 NGIPPTTTQILLEALEKWTQYRITTVAHTEVGPGPESSPVVVRTDEDVPSAPPRKVEAEA 731
Query: 408 VESTQVRITWKKPR--QPNGIINQYRVKVLVPETGII-----LENTLL---------TGN 451
+ +T +R+ W+ P + +G I Y+V + E +++ +L T
Sbjct: 732 LNATAIRVLWRSPAPGRQHGQIRGYQVHYVRMEGAEARGPPRIKDVMLADAQWETDDTAE 791
Query: 452 NEYINDPMAPEIVNIVEPMVGLYEGSAEMSSD--------LHSLATFIYNSHPDKNFPAR 503
E + + PE + +G S + T P+ + AR
Sbjct: 792 YEMVITNLQPETAYSITVAAYTMKGDGARSKPKVVVTKGAVLGRPTLSVQQTPEGSLLAR 851
Query: 504 -----NRAEDQ------------TSPVVT-----TRNQYITDIAAEQLSYVIRRLVPFTE 541
AEDQ ++P+ T + ++Y + +YV R
Sbjct: 852 WEPPAGTAEDQVLGYRLQFGREDSTPLATLEFPPSEDRYTASGVHKGATYVFR------- 904
Query: 542 HMISVSAFTIMGEGPPTVLSV--RTRQQVPSSIKIINYKNISSSSILLYWDP--PEYPNG 597
++ + +GE VLS+ T + P ++ N S+ ++LL W P P NG
Sbjct: 905 --LAARSRGGLGEEAAEVLSIPEDTPRGHPQILEAAG--NASAGTVLLRWLPPVPAERNG 960
Query: 598 KITHYTIYAMELDTNRAFQITTI--------DNSFLITGLKKYTKYKMRVAASTHVGESS 649
I YT+ E + T + +N+ + GLK T Y ++V A T G
Sbjct: 961 AIVKYTVAVREAGALGPARETELPAAAEPGAENALTLQGLKPDTAYDLQVRAHTRRGPGP 1020
Query: 650 LSEENDIFVRTSEDEPESSPQDVEVIDVTADEIRLKWSPPEKPNGIIIAYEVLYKNIDTL 709
S + RT + + SP++ +V + + L W P+ N Y++ Y + TL
Sbjct: 1021 FSP--PVRYRTFLRD-QVSPKNFKVKMIMKTSVLLSWEFPDNYNS-PTPYKIQYNGL-TL 1075
Query: 710 YMKNTSTTDIILRNLRPHTLYNISVRSYTRFGHGNQVSSLLSVRTSETVPD--SAPENIT 767
+ + TT ++ +L+PHT YN + G+ + L T+ T + + ++
Sbjct: 1076 DV-DGRTTKKLITHLKPHTFYN-----FVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSVA 1129
Query: 768 YKNISSGEIELSFLPPSSPNGIIQKYTIY---LKRSNGNE 804
K + G I + +LP +Q Y I L++S G +
Sbjct: 1130 PKPDADGFI-MVYLPDGQSPVPVQSYFIVMVPLRKSRGGQ 1168
Score = 104 bits (259), Expect = 1e-21
Identities = 163/730 (22%), Positives = 266/730 (36%), Gaps = 130/730 (17%)
Query: 17 TQVDVSNVVPGTRYDITISSISTTYTSPVTRIVTTNVTKPGP---PVFLAGERVGSAGIL 73
T+ + + P + Y+I +S++++ P + V T + P P + + + ++
Sbjct: 385 TRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMI 444
Query: 74 LSWNTPPNPNGRIISYIVKYKEVCPWMQTVYTQVRSKPDSLEVLLTNLNPGTTYEIKVAA 133
+ W P PNG I Y V Y + P Q + DSL + +L TY ++V A
Sbjct: 445 VQWEEPVEPNGLIRGYRVYYT-MEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLA 503
Query: 134 ENSAGIGVFSDPFLFQTAESAPGKVVNLTVEAYNASAVKLIWYLPRQPNGKITSFKISVK 193
S G G SDP +T + PG+ +NL EA + +++ L W PRQ + I +++ +
Sbjct: 504 FTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPRQES--IIKYELLFR 561
Query: 194 HARSGIVVKDVSIRVEDILTGKLPECNENSESFLWSTASPSPT-LGRVTP--PSRTTHSS 250
G V R D T + E + + + + A+ SP LG TP RT S
Sbjct: 562 EGDHGREVG----RTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSK 617
Query: 251 STLTQNEISSV----------WKEP---------ISFVVTH---------------LRPY 276
+ ++ V W+ P + + V + + P
Sbjct: 618 PSAPPQDVKCVSVRSTAILVSWRPPPPETHNGALVGYSVRYRPLGSEDPEPKEVNGIPPT 677
Query: 277 TTYLF-----------EVSAATTEAG---YIDSTIVRTPESVPEGPPQNCVTGNITGKSF 322
TT + + A TE G +VRT E VP PP+ + +
Sbjct: 678 TTQILLEALEKWTQYRITTVAHTEVGPGPESSPVVVRTDEDVPSAPPRKVEAEALNATAI 737
Query: 323 SILWDPPT------IVTGKFSYRVELYGPSG----RILD----------NSTKDLKFAFT 362
+LW P + G + V + G RI D + T + + T
Sbjct: 738 RVLWRSPAPGRQHGQIRGYQVHYVRMEGAEARGPPRIKDVMLADAQWETDDTAEYEMVIT 797
Query: 363 NLTPFTMYDVYIAAETSAGTGPKSNISVFTPPDVPGAVFDLQLAEVEST---QVRITWKK 419
NL P T Y + +AA T G G +S V GAV V+ T + W+
Sbjct: 798 NLQPETAYSITVAAYTMKGDGARSKPKVVV---TKGAVLGRPTLSVQQTPEGSLLARWEP 854
Query: 420 PR-QPNGIINQYRVKVLVPETGIILENTLLTGNNEYINDPMAPEIVNIVEPMVGLYEGSA 478
P + YR++ ++ + + Y + + G
Sbjct: 855 PAGTAEDQVLGYRLQFGREDSTPLATLEFPPSEDRYTASGVHKGATYVFRLAARSRGGLG 914
Query: 479 EMSSDLHSLATFIYNSHPDKNFPARNRAEDQT-----SPVVTTRNQYI------------ 521
E ++++ S+ HP A N + PV RN I
Sbjct: 915 EEAAEVLSIPEDTPRGHPQILEAAGNASAGTVLLRWLPPVPAERNGAIVKYTVAVREAGA 974
Query: 522 ------TDIAA-----EQLSYVIRRLVPFTEHMISVSAFTIMGEG---PPTVLSVRTRQQ 567
T++ A + + ++ L P T + + V A T G G PP R Q
Sbjct: 975 LGPARETELPAAAEPGAENALTLQGLKPDTAYDLQVRAHTRRGPGPFSPPVRYRTFLRDQ 1034
Query: 568 V-PSSIKIINYKNISSSSILLYWDPPEYPNGKITHYTIY-AMELDTNRAFQITTIDNSFL 625
V P + K+ K I +S+LL W+ P+ N + Y + LD + L
Sbjct: 1035 VSPKNFKV---KMIMKTSVLLSWEFPDNYNSPTPYKIQYNGLTLDVDGR------TTKKL 1085
Query: 626 ITGLKKYTKY 635
IT LK +T Y
Sbjct: 1086 ITHLKPHTFY 1095
Score = 54.7 bits (130), Expect = 1e-06
Identities = 95/420 (22%), Positives = 166/420 (39%), Gaps = 54/420 (12%)
Query: 1335 TQESVPDVVQNMQCMATSWQSVLVKWDPPKKANGIITQYMVTVERNSTKVSPQDHMYTFI 1394
+ E +P N+ C+A VKW + A + + + V RN ++ T +
Sbjct: 253 SHEIMPGGNVNITCVAVGSPMPYVKW--MQGAEDLTPEDDMPVGRNVLEL-------TDV 303
Query: 1395 KLLANTSYVFKVRASTSAGEGDESTCHVSTLPETVPSVPTNIAFSDVQSTSATLTWI--R 1452
K AN + V A +S G E+ ++ +++P P ++ +TS T+TW
Sbjct: 304 KDSANYTCV----AMSSLGV-IEAVAQITV--KSLPKAPGTPMVTENTATSITITWDSGN 356
Query: 1453 PDTILGYFQNYKITTQLRAQKCKEWESEECVEYQKIQYLYEAHLTEETVYGLKKFRWYRF 1512
PD + Y YK +Q + KE + T ++ GL Y
Sbjct: 357 PDPVSYYVIEYKSKSQDGPYQIKE----------------DITTTRYSIGGLSPNSEYEI 400
Query: 1513 QVAASTNAGYGNASNWISTKTLPGPPDGPPENVHVVATSPFSISISWSEPAVITGPTCYL 1572
V+A + G G S + T+T P P NV S ++ + W EP G
Sbjct: 401 WVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGY 460
Query: 1573 IDVKSVDNDEFNISFIKSNEENKTI-EIKDLEIFTRYSVVITAFTGNISAAYVEGKSSAE 1631
+++ + ++ K N ++ + + L Y+V + AFT + +G S
Sbjct: 461 RVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFT-----SVGDGPLSDP 515
Query: 1632 MIVTTLESAPKDPPNNMTFQKIPDEVTKFQLTFLPPSQPNGNIQVYQALVYREDDPTAVQ 1691
+ V T + P P N + +T L++ PP Q +I Y+ L++RE D
Sbjct: 516 IQVKTQQGVPGQPMNLRAEARSETSIT---LSWSPPRQE--SIIKYE-LLFREGD----- 564
Query: 1692 IHNLSIIQKTNTFVIAMLEGLKGGHTYNISVYAVNSAGAGPKVPM--RITMDIKAPARPK 1749
H + + + ++E LK Y + A + G G P+ + T+ K A P+
Sbjct: 565 -HGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSKPSAPPQ 623
Score = 48.1 bits (113), Expect = 1e-04
Identities = 96/446 (21%), Positives = 161/446 (36%), Gaps = 91/446 (20%)
Query: 12 IGTSETQVDVSNVVPGTRYDITISSISTTYTSPVTR--IVTTNVTKPG-PPVFLAGERVG 68
I + TQ+ + + T+Y IT + + P + +V T+ P PP + E +
Sbjct: 674 IPPTTTQILLEALEKWTQYRITTVAHTEVGPGPESSPVVVRTDEDVPSAPPRKVEAEALN 733
Query: 69 SAGILLSWNTPP--NPNGRIISYIVKYKEV-------CPWMQTVY-TQVRSKPDSL---E 115
+ I + W +P +G+I Y V Y + P ++ V + + D E
Sbjct: 734 ATAIRVLWRSPAPGRQHGQIRGYQVHYVRMEGAEARGPPRIKDVMLADAQWETDDTAEYE 793
Query: 116 VLLTNLNPGTTYEIKVAAENSAGIGVFSDPFLFQTAESAPGKVVNLTVEAYNASAVKLIW 175
+++TNL P T Y I VAA G G S P + T + G+ L+V+ ++ W
Sbjct: 794 MVITNLQPETAYSITVAAYTMKGDGARSKPKVVVTKGAVLGR-PTLSVQQTPEGSLLARW 852
Query: 176 YLPRQPNGKITSFKISVKHARSGIVVKDVSIRVEDILTGKLPECNENSESFLWSTASPSP 235
P + +L +L E+S +P
Sbjct: 853 EPP-------------------------AGTAEDQVLGYRLQFGREDS--------TPLA 879
Query: 236 TLGRVTPPSRTTHSSSTLTQNEISSVWKEPISFVVTHLRPYTTYLFEVSAATTEA-GYID 294
TL PPS +++S + + TY+F ++A + G
Sbjct: 880 TL--EFPPSEDRYTASGVHKG--------------------ATYVFRLAARSRGGLGEEA 917
Query: 295 STIVRTPESVPEGPPQNC-VTGNITGKSFSILWDPPTIVTG-----KFSYRVELYGPSGR 348
+ ++ PE P G PQ GN + + + W PP K++ V G G
Sbjct: 918 AEVLSIPEDTPRGHPQILEAAGNASAGTVLLRWLPPVPAERNGAIVKYTVAVREAGALGP 977
Query: 349 ILDNST-------KDLKFAFTNLTPFTMYDVYIAAETSAGTGPKS---NISVFTPPDVPG 398
+ + L P T YD+ + A T G GP S F V
Sbjct: 978 ARETELPAAAEPGAENALTLQGLKPDTAYDLQVRAHTRRGPGPFSPPVRYRTFLRDQVSP 1037
Query: 399 AVFDLQLAEVESTQVRITWKKPRQPN 424
F +++ + T V ++W+ P N
Sbjct: 1038 KNFKVKM--IMKTSVLLSWEFPDNYN 1061
Score = 45.8 bits (107), Expect = 5e-04
Identities = 78/387 (20%), Positives = 141/387 (36%), Gaps = 66/387 (17%)
Query: 14 TSETQVDVSNVVPGTRYDITISSISTTYTSPVTR--IVTTNVTKPGPPVFLAGERVGSAG 71
T+E ++ ++N+ P T Y IT+++ + ++ +V T G P L+ ++
Sbjct: 789 TAEYEMVITNLQPETAYSITVAAYTMKGDGARSKPKVVVTKGAVLGRPT-LSVQQTPEGS 847
Query: 72 ILLSWNTPPNP-NGRIISYIVKYKEVCPWMQTVYTQVRSKPDSLEVLLTNLNPGTTYEIK 130
+L W P +++ Y +++ T + P + ++ G TY +
Sbjct: 848 LLARWEPPAGTAEDQVLGYRLQFGRED---STPLATLEFPPSEDRYTASGVHKGATYVFR 904
Query: 131 VAAENSAGIGVFSDPFLFQTAESAPGKVVNLTVEAYNASA--VKLIWY--LPRQPNGKIT 186
+AA + G+G + L E P + A NASA V L W +P + NG I
Sbjct: 905 LAARSRGGLGEEAAEVL-SIPEDTPRGHPQILEAAGNASAGTVLLRWLPPVPAERNGAIV 963
Query: 187 SFKISVKHARSGIVVKDVSIRVEDILTGKLPECNENSESFLWSTASPSPTLGRVTPPSRT 246
+ ++V+ A G L E P +
Sbjct: 964 KYTVAVREA------------------GALGPARETE-----------------LPAAAE 988
Query: 247 THSSSTLTQNEISSVWKEPISFVVTHLRPYTTYLFEVSAATTEAGYIDSTIVRTPESV-P 305
+ + LT + L+P T Y +V A T S VR +
Sbjct: 989 PGAENALT---------------LQGLKPDTAYDLQVRAHTRRGPGPFSPPVRYRTFLRD 1033
Query: 306 EGPPQNCVTGNITGKSFSILWDPPTIVTGKFSYRVELYGPSGRILDNSTKDLKFAFTNLT 365
+ P+N I S + W+ P Y+++ +G LD + K T+L
Sbjct: 1034 QVSPKNFKVKMIMKTSVLLSWEFPDNYNSPTPYKIQY---NGLTLDVDGRTTKKLITHLK 1090
Query: 366 PFTMYDVYIAAETSAGTGPKSNISVFT 392
P T Y+ + S+ G + ++ +T
Sbjct: 1091 PHTFYNFVLTNRGSSLGGLQQTVTAWT 1117
>gi|157419150 protein tyrosine phosphatase, receptor type, M isoform 2
precursor [Homo sapiens]
Length = 1452
Score = 240 bits (612), Expect = 1e-62
Identities = 251/998 (25%), Positives = 395/998 (39%), Gaps = 164/998 (16%)
Query: 1404 FKVRASTSAGEGDESTCHVSTLPETVPSVPTNIAFSDVQSTSATLTWIRPDTILGYFQNY 1463
++ T G G + + VP P +A S AT WI+ +
Sbjct: 258 YRCMIRTEGGVGISNYAELVVKEPPVPIAPPQLA-----SVGATYLWIQLNANSINGDGP 312
Query: 1464 KITTQLR-AQKCKEWESEECVEYQKIQYLYEAHLTEETVYGLKKFRWYRFQVAASTNAGY 1522
+ ++ W + V+ + HL +T Y + + G
Sbjct: 313 IVAREVEYCTASGSWNDRQPVDSTSYKI---GHLDPDTEYEISVL------LTRPGEGGT 363
Query: 1523 GNASNWISTKTLPGPPDGPPENVHVVATSPFSISISWSEPAV---------ITGPTCYLI 1573
G+ + T+T P P + VV I+I W +T CY +
Sbjct: 364 GSPGPALRTRTKCADPMRGPRKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYCYQV 423
Query: 1574 DVKSVDNDEFNISFIKSNEENKTIEIKDLEIFTRYSVVITAFTGNISAAYVEG-KSSAEM 1632
+ +E + S+ ++ I +L +T SV + EG K S E+
Sbjct: 424 GGQEQVREEVSWDTENSHPQHT---ITNLSPYTNVSVKLILMNP-------EGRKESQEL 473
Query: 1633 IVTTLESAPKDPPNNMTFQKIPDEVTKFQLTFLPPSQPNGNIQVYQALVYR---EDDPTA 1689
IV T E P P +E K L + P+Q G I +Y+ + Y+ DP
Sbjct: 474 IVQTDEDLPGAVPTESIQGSTFEE--KIFLQWREPTQTYGVITLYE-ITYKAVSSFDPEI 530
Query: 1690 VQIHNLSIIQKTNTFVIAMLEGLKGGHTYNISVYAVNSAGAGPKVPMRITMDIKAPARPK 1749
+ + K + GL G TY+ ++ A + G GP + T I AP+ P
Sbjct: 531 DLSNQSGRVSKLGNETHFLFFGLYPGTTYSFTIRASTAKGFGPPATNQFTTKISAPSMPA 590
Query: 1750 TKPTPIYDATGKLLVTSTTITIRMPICYYSDDHGPIKNVQVLVTETGAQHDGNVTKWYDA 1809
Y+ L T T+T+ + + P+ Q++V E + T+
Sbjct: 591 ------YELETPLNQTDNTVTVMLKPAHSRG--APVSVYQIVVEEERPRRTKKTTEILKC 642
Query: 1810 Y-----FNKAR----PYFTNEGFPNPPCTEGKTKFSGNEEIYIIGADNACMIPGNEDKIC 1860
Y F A Y+ FP + G+ + Y +
Sbjct: 643 YPVPIHFQNASLLNSQYYFAAEFPADSLQAAQPFTIGDNKTY--------------NGYW 688
Query: 1861 NGPLKPKKQYLFKFRATNIMGQFTDSDYSDPVKTLG----------EGLSERTVEIILSV 1910
N PL P K Y F+A + T D V T G E ++ TV+I +
Sbjct: 689 NTPLLPYKSYRIYFQAASRANGETKIDCVQ-VATKGAATPKPVPEPEKQTDHTVKIAGVI 747
Query: 1911 T-LCILSIILLGTAIFAFARIRQKQK-----------------------EGGTYSPQDAE 1946
+ + II LG + R K++ E GT +
Sbjct: 748 AGILLFVIIFLGVVLVMKKRKLAKKRKETMSSTRQEMTVMVNSMDKSYAEQGTNCDEAFS 807
Query: 1947 IIDTK--------------LKLDQLIT-VADLELKDER---------LTRLLSYRK---- 1978
+DT +K + L T V + DE L + +Y+K
Sbjct: 808 FMDTHNLNGRSVSSPSSFTMKTNTLSTSVPNSYYPDETHTMASDTSSLVQSHTYKKREPA 867
Query: 1979 -------SIKP-ISKKSFLQHVEELCTNNNLKFQEEFSELPKFLQDLSSTDADLPW---- 2026
+ P I LQH+ ++ F+EE+ F + S+ PW
Sbjct: 868 DVPYQTGQLHPAIRVADLLQHITQMKCAEGYGFKEEYES---FFEGQSA-----PWDSAK 919
Query: 2027 ---NRAKNRFPNIKPYNNNRVKLIADASVPGSDYINASYISGYLCPNEFIATQGPLPGTV 2083
NR KNR+ NI Y+++RV+L SDYIN +YI GY PN +IATQGP+ T+
Sbjct: 920 KDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQETI 979
Query: 2084 GDFWRMVWETRAKTLVMLTQCFEKGRIRCHQYWPEDNKPVTVFGDIVITKLMEDVQIDWT 2143
DFWRMVW +++M+T E GR++C +YWP+D + ++ DI +T + ++ ++
Sbjct: 980 YDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDDTE---IYKDIKVTLIETELLAEYV 1036
Query: 2144 IRDLKIERHG--DCMTVRQCNFTAWPEHGVPENSAPLIHFVKLVRASRAHDTTPMIVHCS 2201
IR +E+ G + +RQ +FT WP+HGVP ++ L+ FV+ V++ P++VHCS
Sbjct: 1037 IRTFAVEKRGVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQVKSKSPPSAGPLVVHCS 1096
Query: 2202 AGVGRTGVFIALDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLLS 2261
AG GRTG FI +D + VDIY V ELRS R+ MVQ QY+F+H IL+
Sbjct: 1097 AGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEACL 1156
Query: 2262 NKGSNQPICFVNYSALQKMDSLDAMEGDVELEWEETTM 2299
++ P V S M+ LD +++ E T+
Sbjct: 1157 CGDTSVPASQVR-SLYYDMNKLDPQTNSSQIKEEFRTL 1193
Score = 104 bits (259), Expect = 1e-21
Identities = 85/277 (30%), Positives = 127/277 (45%), Gaps = 20/277 (7%)
Query: 1999 NNLKFQEEFSELPKFLQDLSSTDAD---LPWNRAKNRFPNIKPYNNNRVKLIADASVPGS 2055
N+ + +EEF L L D LP N KNR +I P + LI S
Sbjct: 1182 NSSQIKEEFRTLNMVTPTLRVEDCSIALLPRNHEKNRCMDILPPDRCLPFLIT-IDGESS 1240
Query: 2056 DYINASYISGYLCPNEFIATQGPLPGTVGDFWRMVWETRAKTLVMLTQCFEKGRIRCHQY 2115
+YINA+ + Y P+ FI TQ PLP TV DFWR+V + ++VML + ++ C QY
Sbjct: 1241 NYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLND-VDPAQL-CPQY 1298
Query: 2116 WPEDNKPVTVFGDIVITKLMEDVQIDWTIRDLKI----ERHGDCMTVRQCNFTAWPEHGV 2171
WPE+ V G I + + D++ D R +I V+Q F WP +
Sbjct: 1299 WPENG--VHRHGPIQVEFVSADLEEDIISRIFRIYNAARPQDGYRMVQQFQFLGWPMY-- 1354
Query: 2172 PENSAPLIHFVKLVRASRAHDTT------PMIVHCSAGVGRTGVFIALDHLTQHINDHDF 2225
+ F+KL+R +VHC G GR+G F A+ + + +
Sbjct: 1355 RDTPVSKRSFLKLIRQVDKWQEEYNGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRT 1414
Query: 2226 VDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLLSN 2262
VD++ V LR+ + MV L QY F ++ L+ L++
Sbjct: 1415 VDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLNS 1451
Score = 67.8 bits (164), Expect = 1e-10
Identities = 89/364 (24%), Positives = 143/364 (39%), Gaps = 54/364 (14%)
Query: 512 PVVTTRNQYITDIAA-------EQLSYVIRRLVPFTEHMISVSAFTIMGEG----PPTVL 560
P+V +Y T + + SY I L P TE+ ISV T GEG P L
Sbjct: 312 PIVAREVEYCTASGSWNDRQPVDSTSYKIGHLDPDTEYEISV-LLTRPGEGGTGSPGPAL 370
Query: 561 SVRTR----QQVPSSIKIINYKNISSSSILLYWDPPEYPNGKI------THYTIYAMELD 610
RT+ + P ++++ K S I + W+P Y + HY +
Sbjct: 371 RTRTKCADPMRGPRKLEVVEVK---SRQITIRWEPFGYNVTRCHSYNLTVHYCYQVGGQE 427
Query: 611 TNRAFQITTIDNSF---LITGLKKYTKYKMRVAASTHVGESSLSEENDIFVRTSEDEPES 667
R +NS IT L YT +++ G E ++ V+T ED P +
Sbjct: 428 QVREEVSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGRK---ESQELIVQTDEDLPGA 484
Query: 668 SPQDVEVIDVTADEIRLKWSPPEKPNGIIIAYEVLYKNIDTL------------YMKNTS 715
P + ++I L+W P + G+I YE+ YK + + K +
Sbjct: 485 VPTESIQGSTFEEKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGN 544
Query: 716 TTDIILRNLRPHTLYNISVRSYTRFGHGNQVSSLLSVRTS-ETVPDSAPENITYKNISSG 774
T + L P T Y+ ++R+ T G G ++ + + S ++P A E T N +
Sbjct: 545 ETHFLFFGLYPGTTYSFTIRASTAKGFGPPATNQFTTKISAPSMP--AYELETPLNQTDN 602
Query: 775 EIELSFLPPSSPNGIIQKYTIYLKRSNGNEERTINTTSLTQNIKVLKKYTQYIIEVSAST 834
+ + P S + Y I ++ EER T T+ +LK Y I +AS
Sbjct: 603 TVTVMLKPAHSRGAPVSVYQIVVE-----EERPRRTKKTTE---ILKCYPVPIHFQNASL 654
Query: 835 LKGE 838
L +
Sbjct: 655 LNSQ 658
Score = 65.5 bits (158), Expect = 6e-10
Identities = 49/182 (26%), Positives = 78/182 (42%), Gaps = 15/182 (8%)
Query: 1114 NLEKYTDYILKITPSTEKGFSDTYTAQLYIKTEEDVPETSPIINTFKNLSSTSVLLSWDP 1173
NL YT+ +K+ +G ++ +L ++T+ED+P P + + + L W
Sbjct: 448 NLSPYTNVSVKLILMNPEGRKESQ--ELIVQTDEDLPGAVPTESIQGSTFEEKIFLQWRE 505
Query: 1174 PVKPNGAIISYDLT------------LQGPNENYSFITSDNYIILEELSPFTLYSFFAAA 1221
P + G I Y++T L + S + ++ + + L P T YSF A
Sbjct: 506 PTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNETHFLFFGLYPGTTYSFTIRA 565
Query: 1222 RTRKGLGPSSILFFYTDESVPLAPPQNL-TLINCTSDFVWLKWSPSPLPGGIVKVYSFKI 1280
T KG GP + F T S P P L T +N T + V + P+ G V VY +
Sbjct: 566 STAKGFGPPATNQFTTKISAPSMPAYELETPLNQTDNTVTVMLKPAHSRGAPVSVYQIVV 625
Query: 1281 HE 1282
E
Sbjct: 626 EE 627
Score = 57.8 bits (138), Expect = 1e-07
Identities = 78/356 (21%), Positives = 140/356 (39%), Gaps = 49/356 (13%)
Query: 1129 TEKGFSDTYTAQLYIKTEEDVPETSPIINTFKNLSSTSVLLSWDP----PVKPNGAIISY 1184
TE G + A+L +K E VP P L+S W + +G I++
Sbjct: 264 TEGGVGISNYAELVVK-EPPVPIAPP------QLASVGATYLWIQLNANSINGDGPIVAR 316
Query: 1185 DL---TLQGPNENYSFITSDNYIILEELSPFTLYSFFAAARTRKGLG----PSSILFFYT 1237
++ T G + + S +Y I L P T Y + TR G G P L T
Sbjct: 317 EVEYCTASGSWNDRQPVDSTSYKI-GHLDPDTEYEI-SVLLTRPGEGGTGSPGPALRTRT 374
Query: 1238 DESVPLAPPQNLTLINCTSDFVWLKWSPSPLPGGIVKVYSFKIH--------EHETDTIY 1289
+ P+ P+ L ++ S + ++W P Y+ +H E + +
Sbjct: 375 KCADPMRGPRKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYCYQVGGQEQVREEVS 434
Query: 1290 YKNISGFKTEAKLVGLEPVSTYSIRVSAFTKVGNGNQFSNVVKFTTQESVPDVVQNMQCM 1349
+ + + + L P + S+++ G +V+ T E +P V
Sbjct: 435 W-DTENSHPQHTITNLSPYTNVSVKLILMNPEGRKESQELIVQ--TDEDLPGAVPTESIQ 491
Query: 1350 ATSWQS-VLVKWDPPKKANGIITQYMVTVERNST---------------KVSPQDHMYTF 1393
++++ + ++W P + G+IT Y +T + S+ K+ + H + F
Sbjct: 492 GSTFEEKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNETH-FLF 550
Query: 1394 IKLLANTSYVFKVRASTSAGEGDESTCHVSTLPETVPSVPTNIAFSDVQSTSATLT 1449
L T+Y F +RAST+ G G +T +T + PS+P + + T T+T
Sbjct: 551 FGLYPGTTYSFTIRASTAKGFGPPATNQFTT-KISAPSMPAYELETPLNQTDNTVT 605
Score = 48.1 bits (113), Expect = 1e-04
Identities = 45/184 (24%), Positives = 72/184 (39%), Gaps = 23/184 (12%)
Query: 270 VTHLRPYTTYLFEVSAATTEAGY-IDSTIVRTPESVPEGPPQNCVTGNITGKSFSILWDP 328
+T+L PYT ++ E IV+T E +P P + G+ + + W
Sbjct: 446 ITNLSPYTNVSVKLILMNPEGRKESQELIVQTDEDLPGAVPTESIQGSTFEEKIFLQWRE 505
Query: 329 PTIVTG-------------KFSYRVELYGPSGRI--LDNSTKDLKFAFTNLTPFTMYDVY 373
PT G F ++L SGR+ L N T F F L P T Y
Sbjct: 506 PTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNETH---FLFFGLYPGTTYSFT 562
Query: 374 IAAETSAGTGPKSN---ISVFTPPDVPGAVFDLQLAEVESTQVRITWKKPRQPNGIINQY 430
I A T+ G GP + + + P +P + L + ++T V + K ++ Y
Sbjct: 563 IRASTAKGFGPPATNQFTTKISAPSMPAYELETPLNQTDNT-VTVMLKPAHSRGAPVSVY 621
Query: 431 RVKV 434
++ V
Sbjct: 622 QIVV 625
Score = 47.0 bits (110), Expect = 2e-04
Identities = 85/414 (20%), Positives = 153/414 (36%), Gaps = 66/414 (15%)
Query: 267 SFVVTHLRPYTTYLFEVSAATTEAGYIDSTI------VRTPESVPEGPPQNCVTGNITGK 320
S+ + HL P T Y E+S T G + RT + P P+ + +
Sbjct: 337 SYKIGHLDPDTEY--EISVLLTRPGEGGTGSPGPALRTRTKCADPMRGPRKLEVVEVKSR 394
Query: 321 SFSILWDPPTI-VTGKFSYRVELY-----GPSGRILDNSTKDLK-----FAFTNLTPFTM 369
+I W+P VT SY + ++ G ++ + + D + TNL+P+T
Sbjct: 395 QITIRWEPFGYNVTRCHSYNLTVHYCYQVGGQEQVREEVSWDTENSHPQHTITNLSPYTN 454
Query: 370 YDVYIAAETSAGTGPKSNISVFTPPDVPGAV--FDLQLAEVESTQVRITWKKPRQPNGII 427
V + G + V T D+PGAV +Q + E ++ + W++P Q G+I
Sbjct: 455 VSVKLILMNPEGRKESQELIVQTDEDLPGAVPTESIQGSTFEE-KIFLQWREPTQTYGVI 513
Query: 428 NQYRVKVLVPETGIILENTLLTGNNEYINDPMAPEIVNIVEPMVGLYEGSAEMSSDLHSL 487
Y + + V+ +P + L S +S +
Sbjct: 514 TLYEITY---------------------------KAVSSFDPEIDLSNQSGRVSKLGNET 546
Query: 488 ATFIYNSHPDKNFPARNRAEDQTSPVVTTRNQYITDIAAEQL-SYVIRRLVPFTEHMISV 546
+ +P + RA NQ+ T I+A + +Y + + T++ ++V
Sbjct: 547 HFLFFGLYPGTTYSFTIRASTAKGFGPPATNQFTTKISAPSMPAYELETPLNQTDNTVTV 606
Query: 547 SAFTIMGEGPP-TVLSVRTRQQVPSSIKIINYKNISSSSILLYWDPPEYPNGKI---THY 602
G P +V + ++ P K ++ + Y P + N + +Y
Sbjct: 607 MLKPAHSRGAPVSVYQIVVEEERPRRTK------KTTEILKCYPVPIHFQNASLLNSQYY 660
Query: 603 TIYAMELDTNRAFQITTID-----NSFLITGLKKYTKYKMRV-AASTHVGESSL 650
D+ +A Q TI N + T L Y Y++ AAS GE+ +
Sbjct: 661 FAAEFPADSLQAAQPFTIGDNKTYNGYWNTPLLPYKSYRIYFQAASRANGETKI 714
Score = 45.8 bits (107), Expect = 5e-04
Identities = 56/238 (23%), Positives = 95/238 (39%), Gaps = 23/238 (9%)
Query: 1162 LSSTSVLLSWDPPVKPNGAIISYDLTL---------QGPNENYSFITSDNYI--ILEELS 1210
+ S + + W+P SY+LT+ + E S+ T +++ + LS
Sbjct: 391 VKSRQITIRWEPFGYNVTRCHSYNLTVHYCYQVGGQEQVREEVSWDTENSHPQHTITNLS 450
Query: 1211 PFTLYSFFAAARTRKGLGPSSILFFYTDESVPLAPPQNLTLINCTSDFVWLKWSPSPLPG 1270
P+T S +G S L TDE +P A P + + ++L+W
Sbjct: 451 PYTNVSVKLILMNPEGRKESQELIVQTDEDLPGAVPTESIQGSTFEEKIFLQWREPTQTY 510
Query: 1271 GIVKVY--SFKIHEHETDTIYYKNIS------GFKTEAKLVGLEPVSTYSIRVSAFTKVG 1322
G++ +Y ++K I N S G +T GL P +TYS + A T G
Sbjct: 511 GVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNETHFLFFGLYPGTTYSFTIRASTAKG 570
Query: 1323 NGNQFSNVVKFTTQESVPDV--VQNMQCMATSWQSVLVKWDPPKKANGIITQYMVTVE 1378
G +N +FTT+ S P + + + + +V V P ++ Y + VE
Sbjct: 571 FGPPATN--QFTTKISAPSMPAYELETPLNQTDNTVTVMLKPAHSRGAPVSVYQIVVE 626
Score = 45.4 bits (106), Expect = 6e-04
Identities = 76/325 (23%), Positives = 115/325 (35%), Gaps = 26/325 (8%)
Query: 837 GEGVRSAPISILTEEDAPDSPPQDFSVK------QLSGVTVKLSWQPPLEPNGIILYYTV 890
G G+ + ++ E P +PPQ SV QL+ ++ + P+ +
Sbjct: 267 GVGISNYAELVVKEPPVPIAPPQLASVGATYLWIQLNANSI--NGDGPIVAREVEYCTAS 324
Query: 891 YVWNRSSLKTINVTETSLELSDLDYNVEYSAYVTASTRFGDGKTRSN--IISFQTPEGAP 948
WN V TS ++ LD + EY V TR G+G T S + +T P
Sbjct: 325 GSWNDRQ----PVDSTSYKIGHLDPDTEYEISVLL-TRPGEGGTGSPGPALRTRTKCADP 379
Query: 949 SDPPKDVYYANLSSSSIILFWTPPSKPNGIIQYYSVYYRNTSGTFMQNFTLHEVTNDFDN 1008
P+ + + S I + W P Y++ Q EV+ D +N
Sbjct: 380 MRGPRKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYCYQVGGQEQVREEVSWDTEN 439
Query: 1009 MTVSTIIDKLTIFSYYTFWLTASTSVGNGNKSSDIIEVYTDQDIPEGFVGNLTYESISST 1068
I L+ ++ + L G K S + V TD+D+P S
Sbjct: 440 SHPQHTITNLSPYTNVSVKLILMNP--EGRKESQELIVQTDEDLPGAVPTESIQGSTFEE 497
Query: 1069 AINVSWVPPAQPNGLVFYY------VSLI---LQQTPRHVRPPLVTYERSIYFDNLEKYT 1119
I + W P Q G++ Y VS + + + R + E F L T
Sbjct: 498 KIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNETHFLFFGLYPGT 557
Query: 1120 DYILKITPSTEKGFSDTYTAQLYIK 1144
Y I ST KGF T Q K
Sbjct: 558 TYSFTIRASTAKGFGPPATNQFTTK 582
Score = 43.1 bits (100), Expect = 0.003
Identities = 68/329 (20%), Positives = 119/329 (36%), Gaps = 27/329 (8%)
Query: 1222 RTRKGLGPSSILFFYTDES-VPLAPPQNLTLINCTSDFVWLKWSPSPLPGGIVKVYSFKI 1280
RT G+G S+ E VP+APPQ L + + ++W++ + + + G + + ++
Sbjct: 263 RTEGGVGISNYAELVVKEPPVPIAPPQ---LASVGATYLWIQLNANSINGD-GPIVAREV 318
Query: 1281 HEHETDTIYYKNISGFKTEAKLVGLEPVSTYSIRVSAFTKVGNGNQFSNVVKFTTQESVP 1340
+ T K+ L+P + Y I V T+ G G S T+
Sbjct: 319 EYCTASGSWNDRQPVDSTSYKIGHLDPDTEYEISV-LLTRPGEGGTGSPGPALRTRTKCA 377
Query: 1341 DVVQN---MQCMATSWQSVLVKWDPPKKANGIITQYMVTV-------------ERNSTKV 1384
D ++ ++ + + + ++W+P Y +TV E S
Sbjct: 378 DPMRGPRKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYCYQVGGQEQVREEVSWDT 437
Query: 1385 SPQDHMYTFIKLLANTSYVFKVRASTSAGEGDESTCHVSTLPETVPSVPTNIAFSDVQST 1444
+T L T+ K+ G + V T + +VPT
Sbjct: 438 ENSHPQHTITNLSPYTNVSVKLILMNPEGRKESQELIVQTDEDLPGAVPTESIQGSTFEE 497
Query: 1445 SATLTWIRPDTILGYFQNYKITTQLRAQKCKEWESEECVEYQKIQYLYEAHLTEETVYGL 1504
L W P G Y+IT + ++ E + Q + + T +GL
Sbjct: 498 KIFLQWREPTQTYGVITLYEIT----YKAVSSFDPEIDLSNQSGRVSKLGNETHFLFFGL 553
Query: 1505 KKFRWYRFQVAASTNAGYG-NASNWISTK 1532
Y F + AST G+G A+N +TK
Sbjct: 554 YPGTTYSFTIRASTAKGFGPPATNQFTTK 582
Score = 41.6 bits (96), Expect = 0.009
Identities = 83/401 (20%), Positives = 148/401 (36%), Gaps = 29/401 (7%)
Query: 735 RSYTRFGHGNQVSSLLSVRTSETVPDSAPENITYKNISSGEIELSFLPPSSPNGIIQKYT 794
R R G +S+ + E AP + + I+L+ + I+ +
Sbjct: 259 RCMIRTEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWIQLNANSINGDGPIVAREV 318
Query: 795 IYLKRSNG-NEERTINTTSLTQNIKVLKKYTQYIIEVSASTLKGEGVRSAPISIL---TE 850
Y S N+ + +++TS I L T+Y I V T GEG +P L T+
Sbjct: 319 EYCTASGSWNDRQPVDSTSY--KIGHLDPDTEYEISVLL-TRPGEGGTGSPGPALRTRTK 375
Query: 851 EDAPDSPPQDFSVKQLSGVTVKLSWQP------PLEPNGIILYYTVYVWNRSSLKTINVT 904
P P+ V ++ + + W+P + ++Y V + ++
Sbjct: 376 CADPMRGPRKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYCYQVGGQEQVREEVSW 435
Query: 905 ETSLELSDLDYNV-EYSAYVTASTRF----GDGKTRSNIISFQTPEGAPSDPPKDVYYAN 959
+T E S + + S Y S + +G+ S + QT E P P + +
Sbjct: 436 DT--ENSHPQHTITNLSPYTNVSVKLILMNPEGRKESQELIVQTDEDLPGAVPTESIQGS 493
Query: 960 LSSSSIILFWTPPSKPNGIIQYYSVYYRNTSGTFMQNFTLHEVTNDFDNMTVST--IIDK 1017
I L W P++ G+I Y + Y+ S +F L + + T +
Sbjct: 494 TFEEKIFLQWREPTQTYGVITLYEITYKAVS-SFDPEIDLSNQSGRVSKLGNETHFLFFG 552
Query: 1018 LTIFSYYTFWLTASTSVGNGNKSSDIIEVYTDQDIPEGFVGNL-TYESISSTAINVSWVP 1076
L + Y+F + AST+ G G +++ + T P L T + + + V P
Sbjct: 553 LYPGTTYSFTIRASTAKGFGPPATN--QFTTKISAPSMPAYELETPLNQTDNTVTVMLKP 610
Query: 1077 PAQPNGLVFYYVSLILQQTPRHVRPP---LVTYERSIYFDN 1114
V Y ++ ++ PR + L Y I+F N
Sbjct: 611 AHSRGAPVSVYQIVVEEERPRRTKKTTEILKCYPVPIHFQN 651
Score = 36.6 bits (83), Expect = 0.29
Identities = 72/329 (21%), Positives = 110/329 (33%), Gaps = 35/329 (10%)
Query: 15 SETQVDVSNVVPGTRYDITISSISTTYTSPVTR-IVTTNVTKPG--PPVFLAGERVGSAG 71
S Q ++N+ P T + + ++ IV T+ PG P + G
Sbjct: 440 SHPQHTITNLSPYTNVSVKLILMNPEGRKESQELIVQTDEDLPGAVPTESIQGSTFEEK- 498
Query: 72 ILLSWNTPPNPNGRIISYIVKYKEVCPW-----MQTVYTQVRSKPDSLEVLLTNLNPGTT 126
I L W P G I Y + YK V + + +V + L L PGTT
Sbjct: 499 IFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNETHFLFFGLYPGTT 558
Query: 127 YEIKVAAENSAGIGVFSDPFLFQTAESAPG-KVVNLTVEAYNASAVKLIWYLPRQPNG-K 184
Y + A + G G + F T SAP L + P G
Sbjct: 559 YSFTIRASTAKGFGPPATN-QFTTKISAPSMPAYELETPLNQTDNTVTVMLKPAHSRGAP 617
Query: 185 ITSFKISVKHARSGIVVKDVSIRVEDILTGKLPECNENSESFLWSTASPSPTLGRVTPPS 244
++ ++I V+ R K I + + + + ++ P+ +L P
Sbjct: 618 VSVYQIVVEEERPRRTKKTTEILKCYPVPIHFQNASLLNSQYYFAAEFPADSLQAAQP-- 675
Query: 245 RTTHSSSTLTQNE-ISSVWKEPISFVVTHLRPYTTYLFEVSAATTEAGYIDSTIVR---- 299
T+ N+ + W P L PY +Y AA+ G V+
Sbjct: 676 ------FTIGDNKTYNGYWNTP-------LLPYKSYRIYFQAASRANGETKIDCVQVATK 722
Query: 300 ---TPESVPEGPPQNCVTGNITGKSFSIL 325
TP+ VPE Q T I G IL
Sbjct: 723 GAATPKPVPEPEKQTDHTVKIAGVIAGIL 751
>gi|241896926 protein tyrosine phosphatase, receptor type, H isoform 2
precursor [Homo sapiens]
Length = 937
Score = 238 bits (607), Expect = 5e-62
Identities = 124/282 (43%), Positives = 172/282 (60%), Gaps = 5/282 (1%)
Query: 1983 ISKKSFLQHVEELCTNNNLKFQEEFSELPKFLQDLSSTDADLPWNRAKNRFPNIKPYNNN 2042
I + F HV + ++N F +++ +L S A N AKNR+ N+ PY+ +
Sbjct: 622 IPAEDFADHVRKNERDSNCGFADKYQQLSLVGHSQSQMVASASENNAKNRYRNVLPYDWS 681
Query: 2043 RVKLIADASVPGSDYINASYISGYLCPNEFIATQGPLPGTVGDFWRMVWETRAKTLVMLT 2102
RV L PGSDYINAS++ G P EFIATQGPLP TVGDFWR+VWE ++ TLVMLT
Sbjct: 682 RVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQTVGDFWRLVWEQQSHTLVMLT 741
Query: 2103 QCFEKGRIRCHQYWPEDNKPVTVFGDIVITKLMEDVQIDWTIRDLKI--ERHGDCMTVRQ 2160
C E GR++C YWP D++P T G + +T + E+V +WT+R+L + ++VRQ
Sbjct: 742 NCMEAGRVKCEHYWPLDSQPCT-HGHLRVTLVGEEVMENWTVRELLLLQVEEQKTLSVRQ 800
Query: 2161 CNFTAWPEHGVPENSAPLIHFVKLVR--ASRAHDTTPMIVHCSAGVGRTGVFIALDHLTQ 2218
++ AWP+HGVP + L+ F +++R + + P IVHCSAGVGRTG IALD L +
Sbjct: 801 FHYQAWPDHGVPSSPDTLLAFWRMLRQWLDQTMEGGPPIVHCSAGVGRTGTLIALDVLLR 860
Query: 2219 HINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLL 2260
+ + + V ++R R MVQ AQY+FLHQCIL L
Sbjct: 861 QLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRFL 902
Score = 64.3 bits (155), Expect = 1e-09
Identities = 87/373 (23%), Positives = 136/373 (36%), Gaps = 84/373 (22%)
Query: 56 PGPPVFLAGERVGSAGILLSWNTPPNPNGRIISYIVKYKEVCPWMQTV----YTQVRSKP 111
P P L E ++ I LSW P + + +Y W+Q T+ R+
Sbjct: 30 PNPGRNLTVETQTTSSISLSWEVPDGLDSQNSNY---------WVQCTGDGGTTETRNTT 80
Query: 112 DSLEVLLTNLNPGTTYEIKVAAENSAGIGVFSDPFLFQTAESAPGKVVNLTVEAYNASAV 171
+ V + L PG+ Y V E GV S TA +AP V NLTVEA S++
Sbjct: 81 -ATNVTVDGLGPGSLYTCSVWVEKD---GVNSSVGTVTTA-TAPNPVRNLTVEAQTNSSI 135
Query: 172 KLIWYLPRQPNGKITSFKISVKHARSGIVVKDVSIRVEDILTGKLPECNENSESFLWSTA 231
L W +P P+ + +++ V++ G
Sbjct: 136 ALTWEVPDGPDPQNSTY--GVEYTGDG--------------------------------- 160
Query: 232 SPSPTLGRVTPPSRTTHSSSTLTQNEISSVWKEPISFVVTHLRPYTTYLFEVSAATTEAG 291
GR S T H++ T+ + L P Y+F V + G
Sbjct: 161 ------GRAGTRS-TAHTNITVDR-----------------LEPGCLYVFSVWVG--KNG 194
Query: 292 YIDSTIVRTPESVPEGPPQNCVTGNITGKSFSILWD-PPTIVTGKFSYRVELYGPSGRIL 350
S R + P P +N T S ++ W+ P ++Y VE G G
Sbjct: 195 INSSRETRNATTAP-NPVRNLHMETQTNSSIALCWEVPDGPYPQDYTYWVEYTGDGGGTE 253
Query: 351 DNSTKDLKFAFTNLTPFTMYDVYIAAETSAGTGPKSNISVFTPPDVPGAVFDLQLAEVES 410
+T + L P T+Y + AE + G + N+S+ T VP AV L + +
Sbjct: 254 TRNTTNTSVTAERLEPGTLYTFSVWAEKNGARGSRQNVSIST---VPNAVTSLSKQDWTN 310
Query: 411 TQVRITWKKPRQP 423
+ + + W P+ P
Sbjct: 311 STIALRWTAPQGP 323
Score = 63.5 bits (153), Expect = 2e-09
Identities = 99/432 (22%), Positives = 173/432 (40%), Gaps = 43/432 (9%)
Query: 565 RQQVPSSIKIINYKNISSSSILLYWDPPEYPNGKITHYTIYAMELDTNRAFQITTIDNSF 624
R P+ + + + ++SSI L W+ P+ + + ++Y + + TT N
Sbjct: 26 RAPAPNPGRNLTVETQTTSSISLSWEVPDGLDSQNSNYWVQCTGDGGTTETRNTTATN-V 84
Query: 625 LITGLKKYTKYKMRVAASTHVGESSLSEENDIFVRTSEDEPESSPQDVEVIDV---TADE 681
+ GL + Y V SS+ V T+ ++P V + V T
Sbjct: 85 TVDGLGPGSLYTCSVWVEKDGVNSSVGT-----VTTA-----TAPNPVRNLTVEAQTNSS 134
Query: 682 IRLKWSPPEKPNGIIIAYEVLYK-NIDTLYMKNTSTTDIILRNLRPHTLYNISVRSYTRF 740
I L W P+ P+ Y V Y + ++T+ T+I + L P LY SV +
Sbjct: 135 IALTWEVPDGPDPQNSTYGVEYTGDGGRAGTRSTAHTNITVDRLEPGCLYVFSV-----W 189
Query: 741 GHGNQVSSLLSVRTSETVPDSAPENITYKNISSGEIELSFLPPSSPNGIIQKYTIYLK-R 799
N ++S R + T P+ N+ + ++ I L + P P Q YT +++
Sbjct: 190 VGKNGINSSRETRNATTAPNPV-RNLHMETQTNSSIALCWEVPDGP--YPQDYTYWVEYT 246
Query: 800 SNGNEERTINTTSLTQNIKVLKKYTQYIIEVSASTLKGEGVRSAPISILTEEDAPDSPPQ 859
+G T NTT+ + + L+ T Y V A G R +SI T +A S
Sbjct: 247 GDGGGTETRNTTNTSVTAERLEPGTLYTFSVWAEKNGARGSRQ-NVSISTVPNAVTS--- 302
Query: 860 DFSVKQLSGVTVKLSWQPPLEPNGIILYYTVYVWNRSSL---KTINVTETSLELSDLDYN 916
S + + T+ L W P P Y V W R + +T + + T + L +L+
Sbjct: 303 -LSKQDWTNSTIALRWTAPQGPGQSSYSYWV-SWVREGMTDPRTQSTSGTDITLKELEAG 360
Query: 917 VEYSAYVTASTRFGDGKTRSNIISFQTPEGAPSDPPK--DVYYANLSSSSIILFWTPPSK 974
Y V A R+ + + + A + P + D+ + +S++L+W P
Sbjct: 361 SLYHLTVWAE--------RNEVRGYNSTLTAATAPNEVTDLQNETQTKNSVMLWWKAPGD 412
Query: 975 PNGIIQYYSVYY 986
P+ + Y V +
Sbjct: 413 PHSQLYVYWVQW 424
Score = 63.5 bits (153), Expect = 2e-09
Identities = 75/338 (22%), Positives = 140/338 (41%), Gaps = 20/338 (5%)
Query: 554 EGPPTVLSVRTRQQVPSSIKIINYKNISSSSILLYWDPPEYPNGKITHYTIYAMELDTNR 613
+G + + T P+ ++ + + ++SSI L W+ P+ P+ + + Y + D R
Sbjct: 104 DGVNSSVGTVTTATAPNPVRNLTVEAQTNSSIALTWEVPDGPDPQNSTYGVEYTG-DGGR 162
Query: 614 AFQITTIDNSFLITGLKKYTKYKMRVAASTHVGESSLSEENDIFVRTSEDEPESSPQDVE 673
A +T + + L+ Y S VG++ ++ + T+ P +++
Sbjct: 163 AGTRSTAHTNITVDRLEPGCLYVF----SVWVGKNGINSSRETRNATTAPNPV---RNLH 215
Query: 674 VIDVTADEIRLKWSPPEKPNGIIIAYEVLYKNIDT-LYMKNTSTTDIILRNLRPHTLYNI 732
+ T I L W P+ P Y V Y +NT+ T + L P TLY
Sbjct: 216 METQTNSSIALCWEVPDGPYPQDYTYWVEYTGDGGGTETRNTTNTSVTAERLEPGTLYTF 275
Query: 733 SVRSYTRFGHGNQVSSLLSVRTSETVPDSAPENITYKNISSGEIELSFLPPSSPNGIIQK 792
SV + G++ + +S TVP +A +++ ++ ++ I L + P P
Sbjct: 276 SVWAEKNGARGSRQNVSIS-----TVP-NAVTSLSKQDWTNSTIALRWTAPQGPGQSSYS 329
Query: 793 YTIYLKRSNGNEERTINTTSLTQNIKVLKKYTQYIIEVSASTLKGEGVRSAPISILTEED 852
Y + R + RT +T+ +K L+ + Y + V A + G S LT
Sbjct: 330 YWVSWVREGMTDPRTQSTSGTDITLKELEAGSLYHLTVWAERNEVRGYNST----LTAAT 385
Query: 853 APDSPPQDFSVKQLSGVTVKLSWQPPLEPNGIILYYTV 890
AP+ D + + +V L W+ P +P+ + Y V
Sbjct: 386 APNE-VTDLQNETQTKNSVMLWWKAPGDPHSQLYVYWV 422
Score = 56.6 bits (135), Expect = 3e-07
Identities = 120/553 (21%), Positives = 206/553 (37%), Gaps = 73/553 (13%)
Query: 660 TSEDEPESSP-QDVEVIDVTADEIRLKWSPPEKPNGIIIAYEVLYKNID-TLYMKNTSTT 717
T P +P +++ V T I L W P+ + Y V T +NT+ T
Sbjct: 23 TGARAPAPNPGRNLTVETQTTSSISLSWEVPDGLDSQNSNYWVQCTGDGGTTETRNTTAT 82
Query: 718 DIILRNLRPHTLYNISVRSYTRFGHGNQVSSLLSVRTSETVPDSAPENITYKNISSGEIE 777
++ + L P +LY SV + + V+S + T+ T P+ N+T + ++ I
Sbjct: 83 NVTVDGLGPGSLYTCSV-----WVEKDGVNSSVGTVTTATAPNPV-RNLTVEAQTNSSIA 136
Query: 778 LSFLPPSSPNGIIQKYTIYLKRSNGNEERTINTTSLTQNIKVLKKYTQYIIEVSASTLKG 837
L++ P P+ Y + +G T +T + L+ Y+ V
Sbjct: 137 LTWEVPDGPDPQNSTYGVEY-TGDGGRAGTRSTAHTNITVDRLEPGCLYVFSVWVGK--- 192
Query: 838 EGVRSAPISILTEEDAPDSPPQDFSVKQLSGVTVKLSWQPPLEP-NGIILYYTVYVWNRS 896
G+ S+ AP +P ++ ++ + ++ L W+ P P Y+ Y +
Sbjct: 193 NGINSSR-ETRNATTAP-NPVRNLHMETQTNSSIALCWEVPDGPYPQDYTYWVEYTGDGG 250
Query: 897 SLKTINVTETSLELSDLDYNVEYSAYVTASTRFGDGKTRSNIISFQTPEGAPSDPPKDVY 956
+T N T TS+ L+ Y+ V A G +R N+ P S +D
Sbjct: 251 GTETRNTTNTSVTAERLEPGTLYTFSVWAEKNGARG-SRQNVSISTVPNAVTSLSKQD-- 307
Query: 957 YANLSSSSIILFWTPPSKPNGIIQYYSVYY----------RNTSGTFMQNFTLHEVTNDF 1006
++S+I L WT P P Y V + ++TSGT + TL E+ +
Sbjct: 308 ---WTNSTIALRWTAPQGPGQSSYSYWVSWVREGMTDPRTQSTSGT---DITLKEL--EA 359
Query: 1007 DNMTVSTIIDKLTIFSYYTFWLTASTSVGNGNKSSDIIEVYTDQDIPEGFVGNLTYESIS 1066
++ T+ + Y LTA+T+ V +L E+ +
Sbjct: 360 GSLYHLTVWAERNEVRGYNSTLTAATAPNE--------------------VTDLQNETQT 399
Query: 1067 STAINVSWVPPAQPNG-LVFYYVSLILQQTPRHVRPPLV--------TYERSIYFDNLEK 1117
++ + W P P+ L Y+V + PR + P T E + LE
Sbjct: 400 KNSVMLWWKAPGDPHSQLYVYWVQWASKGHPRRGQDPQANWVNQTSRTNETWYKVEALEP 459
Query: 1118 YTDYILKITPSTEKGFSDTYTAQLYIKTEEDVPETSPIINTFKNLSSTSVLLSWDPPVKP 1177
T Y T E+ + T L T P+T I + + V L W P
Sbjct: 460 GTLY--NFTVWAERNDVASSTQSLCAST---YPDTVTITSCVSTSAGYGVNLIWS---CP 511
Query: 1178 NGAIISYDLTLQG 1190
G +++L + G
Sbjct: 512 QGGYEAFELEVGG 524
Score = 53.9 bits (128), Expect = 2e-06
Identities = 60/257 (23%), Positives = 95/257 (36%), Gaps = 19/257 (7%)
Query: 14 TSETQVDVSNVVPGTRYDITISSISTTYTSPVTRIVTTNVTKPGPPVFLAGERVGSAGIL 73
T+ T + V + PG Y ++ S +R T P P L E ++ I
Sbjct: 168 TAHTNITVDRLEPGCLYVFSVWVGKNGINS--SRETRNATTAPNPVRNLHMETQTNSSIA 225
Query: 74 LSWNTPPNPNGRIISYIVKYKEVCPWMQTVYTQVRSKPDSLEVLLTNLNPGTTYEIKVAA 133
L W P P + +Y V+Y +T T + V L PGT Y V A
Sbjct: 226 LCWEVPDGPYPQDYTYWVEYTGDGGGTETRNT------TNTSVTAERLEPGTLYTFSVWA 279
Query: 134 ENSAGIGVFSDPFLFQTAESAPGKVVNLTVEAYNASAVKLIWYLPRQPNGKITSFKISVK 193
E + G + + + P V +L+ + + S + L W P+ P +S+ V
Sbjct: 280 EKNGARGSRQN----VSISTVPNAVTSLSKQDWTNSTIALRWTAPQGPGQ--SSYSYWVS 333
Query: 194 HARSGIVVKDVSIRVEDILTGKLPECNENSESFLWSTASP----SPTLGRVTPPSRTTH- 248
R G+ +T K E +W+ + + TL T P+ T
Sbjct: 334 WVREGMTDPRTQSTSGTDITLKELEAGSLYHLTVWAERNEVRGYNSTLTAATAPNEVTDL 393
Query: 249 SSSTLTQNEISSVWKEP 265
+ T T+N + WK P
Sbjct: 394 QNETQTKNSVMLWWKAP 410
Score = 52.0 bits (123), Expect = 7e-06
Identities = 122/515 (23%), Positives = 198/515 (38%), Gaps = 64/515 (12%)
Query: 856 SPPQDFSVKQLSGVTVKLSWQPPLEPNGIIL----YYTVYVWNRSSLKTINVTETSLELS 911
+P ++ +V+ + ++ LSW+ P +G+ Y+ + + +T N T T++ +
Sbjct: 31 NPGRNLTVETQTTSSISLSWEVP---DGLDSQNSNYWVQCTGDGGTTETRNTTATNVTVD 87
Query: 912 DLDYNVEYSAYVTASTRFGDGKTRSNIISFQTPEGAPSDPPKDVYYANLSSSSIILFWTP 971
L Y+ V DG S + T AP+ P +++ ++SSI L W
Sbjct: 88 GLGPGSLYTCSVWVEK---DGVNSS--VGTVTTATAPN-PVRNLTVEAQTNSSIALTWEV 141
Query: 972 PSKPNGIIQYYSVYYRNTSGTFMQNFTLHEVTNDFDNMTVSTIIDKLTIFSYYTFWLTAS 1031
P P+ Y V Y G T H N+TV D+L Y F S
Sbjct: 142 PDGPDPQNSTYGVEYTGDGGRAGTRSTAH------TNITV----DRLEPGCLYVF----S 187
Query: 1032 TSVG-NGNKSSDIIEVYTDQDIPEGFVGNLTYESISSTAINVSWVPPAQPNGLVF-YYVS 1089
VG NG SS T P V NL E+ ++++I + W P P + Y+V
Sbjct: 188 VWVGKNGINSSRETRNATTAPNP---VRNLHMETQTNSSIALCWEVPDGPYPQDYTYWVE 244
Query: 1090 LILQQTPRHVRPPLVTYERSIYFDNLEKYTDYILKITPSTEKGFSDTYTAQLYIKTEEDV 1149
R T S+ + LE T Y + EK + + I T V
Sbjct: 245 YTGDGGGTETRN---TTNTSVTAERLEPGTLYTFSVW--AEKNGARGSRQNVSIST---V 296
Query: 1150 PETSPIINTFKNLSSTSVLLSWDPPVKPNGAIISY--DLTLQGPNENYSFITSDNYIILE 1207
P ++ ++ +++++ L W P P + SY +G + + TS I L+
Sbjct: 297 PNAVTSLSK-QDWTNSTIALRWTAPQGPGQSSYSYWVSWVREGMTDPRTQSTSGTDITLK 355
Query: 1208 ELSPFTLYSFFAAARTRKGLGPSSILFFYTDESVPLAPPQNLTLIN--CTSDFVWLKWSP 1265
EL +LY A + G +S L + AP + L N T + V L W
Sbjct: 356 ELEAGSLYHLTVWAERNEVRGYNSTL------TAATAPNEVTDLQNETQTKNSVMLWWKA 409
Query: 1266 SPLPGGIVKVY----SFKIHEH--ETDTIYYKNISGFKTEA--KLVGLEPVSTYSIRVSA 1317
P + VY + K H + + N + E K+ LEP + Y+
Sbjct: 410 PGDPHSQLYVYWVQWASKGHPRRGQDPQANWVNQTSRTNETWYKVEALEPGTLYN----- 464
Query: 1318 FTKVGNGNQFSNVVKFTTQESVPDVVQNMQCMATS 1352
FT N ++ + + PD V C++TS
Sbjct: 465 FTVWAERNDVASSTQSLCASTYPDTVTITSCVSTS 499
Score = 50.8 bits (120), Expect = 1e-05
Identities = 50/189 (26%), Positives = 79/189 (41%), Gaps = 16/189 (8%)
Query: 14 TSETQVDVSNVVPGTRYDITISSISTTYTSPVTRIVTTNVTKPGPPVFLAGERVGSAGIL 73
T+ T V + PGT Y T S + + +R + T P L+ + ++ I
Sbjct: 257 TTNTSVTAERLEPGTLY--TFSVWAEKNGARGSRQNVSISTVPNAVTSLSKQDWTNSTIA 314
Query: 74 LSWNTPPNPNGRIISYIVKYKEVCPWMQTVYTQVRSKPDS-LEVLLTNLNPGTTYEIKVA 132
L W P P SY V W++ T R++ S ++ L L G+ Y + V
Sbjct: 315 LRWTAPQGPGQSSYSYWVS------WVREGMTDPRTQSTSGTDITLKELEAGSLYHLTVW 368
Query: 133 AENSAGIGVFSDPFLFQTAESAPGKVVNLTVEAYNASAVKLIWYLPRQPNGKITSFKI-- 190
AE + G S TA +AP +V +L E ++V L W P P+ ++ + +
Sbjct: 369 AERNEVRGYNST----LTAATAPNEVTDLQNETQTKNSVMLWWKAPGDPHSQLYVYWVQW 424
Query: 191 -SVKHARSG 198
S H R G
Sbjct: 425 ASKGHPRRG 433
Score = 48.5 bits (114), Expect = 7e-05
Identities = 87/420 (20%), Positives = 145/420 (34%), Gaps = 75/420 (17%)
Query: 14 TSETQVDVSNVVPGTRYDITISSISTTYTSPVTRIVTTNVTKPGPPVFLAGERVGSAGIL 73
T+ T V V + PG+ Y ++ S V + T T P P L E ++ I
Sbjct: 79 TTATNVTVDGLGPGSLYTCSVWVEKDGVNSSVGTVTTA--TAPNPVRNLTVEAQTNSSIA 136
Query: 74 LSWNTPPNPNGRIISYIVKYKEVCPWMQTVYTQVRSKPDSLEVLLTNLNPGTTYEIKVAA 133
L+W P P+ + +Y V+Y T T + + L PG Y V
Sbjct: 137 LTWEVPDGPDPQNSTYGVEYTGDGGRAGTRSTA------HTNITVDRLEPGCLYVFSVWV 190
Query: 134 ENSAGIGVFSDPFLFQTAESAPGKVVNLTVEAYNASAVKLIWYLPRQPNGKITSFKISVK 193
+ GI + + A +AP V NL +E S++ L W +P P + ++ +
Sbjct: 191 GKN-GINSSRET---RNATTAPNPVRNLHMETQTNSSIALCWEVPDGPYPQDYTYWVEYT 246
Query: 194 HARSGIVVKDVSIRVEDILTGKLPECNENSESFLWSTASPSPTLGRVTPPSRTTHSSSTL 253
G + +T + S T R+ P + T
Sbjct: 247 GDGGGTETR--------------------------NTTNTSVTAERLEPGTLYTF----- 275
Query: 254 TQNEISSVWKEPISFVVTHLRPYTTYLFEVSAATTEAGYIDSTIVRTPESVPEGPPQNCV 313
SVW E + + + + ++ + +STI + P+GP Q
Sbjct: 276 ------SVWAEKNGARGSRQNVSISTVPNAVTSLSKQDWTNSTIA-LRWTAPQGPGQ--- 325
Query: 314 TGNITGKSFSILWDPPTIVTGKFSYRVELYGPSGRILDNSTKDLKFAFTNLTPFTMYDVY 373
+ S+ + W + G R + ST L ++Y +
Sbjct: 326 ----SSYSYWVSW----VREGMTDPRTQ-----------STSGTDITLKELEAGSLYHLT 366
Query: 374 IAAETSAGTGPKSNISVFTPPDVPGAVFDLQLAEVESTQVRITWKKPRQPNGIINQYRVK 433
+ AE + G S ++ T P V DLQ V + WK P P+ + Y V+
Sbjct: 367 VWAERNEVRGYNSTLTAAT---APNEVTDLQNETQTKNSVMLWWKAPGDPHSQLYVYWVQ 423
Score = 43.1 bits (100), Expect = 0.003
Identities = 74/307 (24%), Positives = 118/307 (38%), Gaps = 34/307 (11%)
Query: 1158 TFKNLSSTSVLLSWDPPVKPNGAIISY--DLTLQGPNENYSFITSDNYIILEELSPFTLY 1215
T + +++S+ LSW+ P + +Y T G T+ N + ++ L P +LY
Sbjct: 37 TVETQTTSSISLSWEVPDGLDSQNSNYWVQCTGDGGTTETRNTTATN-VTVDGLGPGSLY 95
Query: 1216 SFFAAARTRKGLGPSSILFFYTDESVPLAPPQNLTLINCTSDFVWLKWSPSPLPGGIVKV 1275
+ + K G +S + T + P P +NLT+ T+ + L W P
Sbjct: 96 T--CSVWVEKD-GVNSSVGTVTTATAP-NPVRNLTVEAQTNSSIALTWEVPDGPDPQNST 151
Query: 1276 YSFKIHEHETDTIYYKNISGFKTEAKLVGLEPVSTYSIRVSAFTKVG-NGNQFSNVVKFT 1334
Y E+ D S T + LEP Y V VG NG S +
Sbjct: 152 YGV---EYTGDGGRAGTRSTAHTNITVDRLEPGCLYVFSVW----VGKNGINSSRETRNA 204
Query: 1335 TQESVPDVVQNMQCMATSWQSVLVKWDPPKKANGIITQYMV--------TVERNSTKVSP 1386
T + P+ V+N+ + S+ + W+ P Y V T RN+T S
Sbjct: 205 T--TAPNPVRNLHMETQTNSSIALCWEVPDGPYPQDYTYWVEYTGDGGGTETRNTTNTS- 261
Query: 1387 QDHMYTFIKLLANTSYVFKVRASTSAGEGDESTCHVSTLPETVPSVPTNIAFSDVQSTSA 1446
T +L T Y F V A + G +ST+P V T+++ D +++
Sbjct: 262 ----VTAERLEPGTLYTFSVWAEKNGARGSRQNVSISTVPNAV----TSLSKQDWTNSTI 313
Query: 1447 TLTWIRP 1453
L W P
Sbjct: 314 ALRWTAP 320
>gi|241896924 protein tyrosine phosphatase, receptor type, H isoform 1
precursor [Homo sapiens]
Length = 1115
Score = 238 bits (607), Expect = 5e-62
Identities = 124/282 (43%), Positives = 172/282 (60%), Gaps = 5/282 (1%)
Query: 1983 ISKKSFLQHVEELCTNNNLKFQEEFSELPKFLQDLSSTDADLPWNRAKNRFPNIKPYNNN 2042
I + F HV + ++N F +++ +L S A N AKNR+ N+ PY+ +
Sbjct: 800 IPAEDFADHVRKNERDSNCGFADKYQQLSLVGHSQSQMVASASENNAKNRYRNVLPYDWS 859
Query: 2043 RVKLIADASVPGSDYINASYISGYLCPNEFIATQGPLPGTVGDFWRMVWETRAKTLVMLT 2102
RV L PGSDYINAS++ G P EFIATQGPLP TVGDFWR+VWE ++ TLVMLT
Sbjct: 860 RVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQTVGDFWRLVWEQQSHTLVMLT 919
Query: 2103 QCFEKGRIRCHQYWPEDNKPVTVFGDIVITKLMEDVQIDWTIRDLKI--ERHGDCMTVRQ 2160
C E GR++C YWP D++P T G + +T + E+V +WT+R+L + ++VRQ
Sbjct: 920 NCMEAGRVKCEHYWPLDSQPCT-HGHLRVTLVGEEVMENWTVRELLLLQVEEQKTLSVRQ 978
Query: 2161 CNFTAWPEHGVPENSAPLIHFVKLVR--ASRAHDTTPMIVHCSAGVGRTGVFIALDHLTQ 2218
++ AWP+HGVP + L+ F +++R + + P IVHCSAGVGRTG IALD L +
Sbjct: 979 FHYQAWPDHGVPSSPDTLLAFWRMLRQWLDQTMEGGPPIVHCSAGVGRTGTLIALDVLLR 1038
Query: 2219 HINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLL 2260
+ + + V ++R R MVQ AQY+FLHQCIL L
Sbjct: 1039 QLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRFL 1080
Score = 76.3 bits (186), Expect = 3e-13
Identities = 101/443 (22%), Positives = 163/443 (36%), Gaps = 53/443 (11%)
Query: 14 TSETQVDVSNVVPGTRYDITISSISTTYTSPVTRIVTTNVTKPGPPVFLAGERVGSAGIL 73
T+ T V V + PG+ Y ++ S V + T T P P L E ++ I
Sbjct: 79 TTATNVTVDGLGPGSLYTCSVWVEKDGVNSSVGTVTTA--TAPNPVRNLRVEAQTNSSIA 136
Query: 74 LSWNTPPNPNGRIISYIVKYKEVCPWMQTVYTQVRSKPDSLEVLLTNLNPGTTYEIKVAA 133
L+W P P+ + +Y V+Y T T + + L PG Y +
Sbjct: 137 LTWEVPDGPDPQNSTYGVEYTGDGGRAGTRSTA------HTNITVDGLEPGCLYAFSMWV 190
Query: 134 ENSAGIGVFSDPFLFQTAESAPGKVVNLTVEAYNASAVKLIWYLPRQPNGKITSFKISVK 193
+ GI + + A +A V NL VEA S++ L W +P + + +++ +
Sbjct: 191 GKN-GINSSRET---RNATTAHNPVRNLRVEAQTTSSISLSWEVPDGTDPQNSTYCVQCT 246
Query: 194 HARSGIVVK---DVSIRVEDILTGKLPECN--------ENSESFLWSTASPSPTLGRVTP 242
+ D + V+ + G L C+ +S + S +P+P R
Sbjct: 247 GDGGRTETRNTTDTRVTVDGLGPGSLYTCSVWVEKDGVNSSVEIVTSATAPNPV--RNLT 304
Query: 243 PSRTTHSSSTLT---------QNEISSVW------------KEPISFVVTHLRPYTTYLF 281
T+SS LT QN V + V L P Y+F
Sbjct: 305 VEAQTNSSIALTWEVPDGPDPQNSTYGVEYTGDGGRAGTRSTAHTNITVDRLEPGCLYVF 364
Query: 282 EVSAATTEAGYIDSTIVRTPESVPEGPPQNCVTGNITGKSFSILWDPPT-IVTGKFSYRV 340
V G S R + P P +N T S ++ W+ P ++Y V
Sbjct: 365 SVWVGKN--GINSSRETRNATTAPN-PVRNLHMETQTNSSIALCWEVPDGPYPQDYTYWV 421
Query: 341 ELYGPSGRILDNSTKDLKFAFTNLTPFTMYDVYIAAETSAGTGPKSNISVFTPPDVPGAV 400
E G G +T + L P T+Y + AE + G + N+S+ T VP AV
Sbjct: 422 EYTGDGGGTETRNTTNTSVTAERLEPGTLYTFSVWAEKNGARGSRQNVSIST---VPNAV 478
Query: 401 FDLQLAEVESTQVRITWKKPRQP 423
L + ++ + + W P+ P
Sbjct: 479 TSLSKQDWTNSTIALRWTAPQGP 501
Score = 75.5 bits (184), Expect = 6e-13
Identities = 151/711 (21%), Positives = 271/711 (38%), Gaps = 80/711 (11%)
Query: 565 RQQVPSSIKIINYKNISSSSILLYWDPPEYPNGKITHYTIYAMELDTNRAFQITTIDNSF 624
R P+ + + + ++SSI L W+ P+ + + ++Y + + TT N
Sbjct: 26 RAPAPNPGRNLTVETQTTSSISLSWEVPDGLDSQNSNYWVQCTGDGGTTETRNTTATN-V 84
Query: 625 LITGLKKYTKYKMRVAASTHVGESSLSEENDIFVRTSEDEPESSPQDVEVIDVTADEIRL 684
+ GL + Y V SS+ T+ P + +++ V T I L
Sbjct: 85 TVDGLGPGSLYTCSVWVEKDGVNSSVG------TVTTATAP-NPVRNLRVEAQTNSSIAL 137
Query: 685 KWSPPEKPNGIIIAYEVLYK-NIDTLYMKNTSTTDIILRNLRPHTLYNISVRSYTRFGHG 743
W P+ P+ Y V Y + ++T+ T+I + L P LY +++ +
Sbjct: 138 TWEVPDGPDPQNSTYGVEYTGDGGRAGTRSTAHTNITVDGLEPGCLY-----AFSMWVGK 192
Query: 744 NQVSSLLSVRTSETVPDSAPENITYKNISSGEIELSFLPPSSPNGIIQKYTIYLKRSNGN 803
N ++S R + T + N+ + ++ I LS+ P + Y + G
Sbjct: 193 NGINSSRETRNATTAHNPV-RNLRVEAQTTSSISLSWEVPDGTDPQNSTYCVQCTGDGGR 251
Query: 804 EERTINTTSLTQNIKVLKKYTQYIIEVSASTLKGEGVRSAPISILTEEDAPDSPPQDFSV 863
E T NTT + L + Y V ++ +GV S+ + I+T AP +P ++ +V
Sbjct: 252 TE-TRNTTDTRVTVDGLGPGSLYTCSV---WVEKDGVNSS-VEIVTSATAP-NPVRNLTV 305
Query: 864 KQLSGVTVKLSWQPPLEPNGIILYYTV-YVWNRSSLKTINVTETSLELSDLDYNVEYSAY 922
+ + ++ L+W+ P P+ Y V Y + T + T++ + L+ Y
Sbjct: 306 EAQTNSSIALTWEVPDGPDPQNSTYGVEYTGDGGRAGTRSTAHTNITVDRLEPGCLYVFS 365
Query: 923 VTASTRFGDGKTRSNIISFQTPEGAPSDPPKDVYYANLSSSSIILFWTPPSKPNGIIQYY 982
V GK N +P ++++ ++SSI L W P P Y
Sbjct: 366 VWV------GKNGINSSRETRNATTAPNPVRNLHMETQTNSSIALCWEVPDGPYPQDYTY 419
Query: 983 SVYYRNTSGTFMQNFTLHEVTNDFDNMTVSTIIDKLTIFSYYTFWLTASTSVGNGNKSSD 1042
V Y G T + S ++L + YTF + A + G++ +
Sbjct: 420 WVEYTGDGGG----------TETRNTTNTSVTAERLEPGTLYTFSVWAEKNGARGSRQNV 469
Query: 1043 IIEVYTDQDIPEGFVGNLTYESISSTAINVSWVPPAQPNGLVF-YYVSLILQ--QTPRHV 1099
I +P V +L+ + +++ I + W P P + Y+VS + + PR
Sbjct: 470 SIST-----VPNA-VTSLSKQDWTNSTIALRWTAPQGPGQSSYSYWVSWVREGMTDPR-- 521
Query: 1100 RPPLVTYERSIYFDNLEKYTDYILKITPSTE--KGFSDTYTAQLYIKTEEDVPETSPIIN 1157
T I LE + Y L + +G++ T TA D+ + N
Sbjct: 522 --TQSTSGTDITLKELEAGSLYHLTVWAERNEVRGYNSTLTAATAPNEVTDLQNETQTKN 579
Query: 1158 TFKNLSSTSVLLSWDPPVKPNGAIISYDLTL---------QGPNENY---SFITSDNYII 1205
SV+L W P P+ + Y + Q P N+ + T++ +
Sbjct: 580 --------SVMLWWKAPGDPHSQLYVYWVQWASKGHPRRGQDPQANWVNQTSRTNETWYK 631
Query: 1206 LEELSPFTLYSFFAAARTRKGLGPSSILFFYTDESVPLAPPQNLTLINCTS 1256
+E L P TLY+F A R + S T P +T+ +C S
Sbjct: 632 VEALEPGTLYNFTVWAE-RNDVASS------TQSLCASTYPDTVTITSCVS 675
Score = 73.2 bits (178), Expect = 3e-12
Identities = 141/658 (21%), Positives = 252/658 (38%), Gaps = 80/658 (12%)
Query: 554 EGPPTVLSVRTRQQVPSSIKIINYKNISSSSILLYWDPPEYPNGKITHYTIYAMELDTNR 613
+G + + T P+ ++ + + ++SSI L W+ P+ P+ + + Y + D R
Sbjct: 104 DGVNSSVGTVTTATAPNPVRNLRVEAQTNSSIALTWEVPDGPDPQNSTYGV-EYTGDGGR 162
Query: 614 AFQITTIDNSFLITGLKKYTKYKMRVAASTHVGESSLSEENDIFVRTSEDEPESSPQDVE 673
A +T + + GL+ Y A S VG++ ++ + T+ P +++
Sbjct: 163 AGTRSTAHTNITVDGLEPGCLY----AFSMWVGKNGINSSRETRNATTAHNP---VRNLR 215
Query: 674 VIDVTADEIRLKWSPPEKPNGIIIAYEV-LYKNIDTLYMKNTSTTDIILRNLRPHTLYNI 732
V T I L W P+ + Y V + +NT+ T + + L P +LY
Sbjct: 216 VEAQTTSSISLSWEVPDGTDPQNSTYCVQCTGDGGRTETRNTTDTRVTVDGLGPGSLYTC 275
Query: 733 SVRSYTRFGHGNQVSSLLSVRTSETVPDSAPENITYKNISSGEIELSFLPPSSPNGIIQK 792
SV + + V+S + + TS T P+ N+T + ++ I L++ P P+
Sbjct: 276 SV-----WVEKDGVNSSVEIVTSATAPNPV-RNLTVEAQTNSSIALTWEVPDGPDPQNST 329
Query: 793 YTIYLKRSNGNEERTINTTSLTQNIKVLKKYTQYIIEVSASTLKGEGVRSAPISILTEED 852
Y + +G T +T + L+ Y+ V G+ S+
Sbjct: 330 YGVEY-TGDGGRAGTRSTAHTNITVDRLEPGCLYVFSVWVGK---NGINSSR-ETRNATT 384
Query: 853 APDSPPQDFSVKQLSGVTVKLSWQPPLEP-NGIILYYTVYVWNRSSLKTINVTETSLELS 911
AP +P ++ ++ + ++ L W+ P P Y+ Y + +T N T TS+
Sbjct: 385 AP-NPVRNLHMETQTNSSIALCWEVPDGPYPQDYTYWVEYTGDGGGTETRNTTNTSVTAE 443
Query: 912 DLDYNVEYSAYVTASTRFGDGKTRSNIISFQTPEGAPSDPPKDVYYANLSSSSIILFWTP 971
L+ Y+ V A G +R N+ P S +D ++S+I L WT
Sbjct: 444 RLEPGTLYTFSVWAEKNGARG-SRQNVSISTVPNAVTSLSKQD-----WTNSTIALRWTA 497
Query: 972 PSKPNGIIQYYSVYY----------RNTSGTFMQNFTLHEVTNDFDNMTVSTIIDKLTIF 1021
P P Y V + ++TSGT + TL E+ + ++ T+ +
Sbjct: 498 PQGPGQSSYSYWVSWVREGMTDPRTQSTSGT---DITLKEL--EAGSLYHLTVWAERNEV 552
Query: 1022 SYYTFWLTASTSVGNGNKSSDIIEVYTDQDIPEGFVGNLTYESISSTAINVSWVPPAQPN 1081
Y LTA+T+ V +L E+ + ++ + W P P+
Sbjct: 553 RGYNSTLTAATAPNE--------------------VTDLQNETQTKNSVMLWWKAPGDPH 592
Query: 1082 G-LVFYYVSLILQQTPRHVRPPLV--------TYERSIYFDNLEKYTDYILKITPSTEKG 1132
L Y+V + PR + P T E + LE T Y T E+
Sbjct: 593 SQLYVYWVQWASKGHPRRGQDPQANWVNQTSRTNETWYKVEALEPGTLY--NFTVWAERN 650
Query: 1133 FSDTYTAQLYIKTEEDVPETSPIINTFKNLSSTSVLLSWDPPVKPNGAIISYDLTLQG 1190
+ T L T P+T I + + V L W P G +++L + G
Sbjct: 651 DVASSTQSLCAST---YPDTVTITSCVSTSAGYGVNLIWS---CPQGGYEAFELEVGG 702
Score = 64.7 bits (156), Expect = 1e-09
Identities = 161/711 (22%), Positives = 267/711 (37%), Gaps = 74/711 (10%)
Query: 660 TSEDEPESSP-QDVEVIDVTADEIRLKWSPPEKPNGIIIAYEVLYKNID-TLYMKNTSTT 717
T P +P +++ V T I L W P+ + Y V T +NT+ T
Sbjct: 23 TGARAPAPNPGRNLTVETQTTSSISLSWEVPDGLDSQNSNYWVQCTGDGGTTETRNTTAT 82
Query: 718 DIILRNLRPHTLYNISVRSYTRFGHGNQVSSLLSVRTSETVPDSAPENITYKNISSGEIE 777
++ + L P +LY SV + + V+S + T+ T P+ N+ + ++ I
Sbjct: 83 NVTVDGLGPGSLYTCSV-----WVEKDGVNSSVGTVTTATAPNPV-RNLRVEAQTNSSIA 136
Query: 778 LSFLPPSSPNGIIQKYTIYLKRSNGNEERTINTTSLTQNIKVLKKYTQYIIEVSASTLKG 837
L++ P P+ Y + +G T +T + L+ Y +
Sbjct: 137 LTWEVPDGPDPQNSTYGVEY-TGDGGRAGTRSTAHTNITVDGLEPGCLYAFSMWVGK--- 192
Query: 838 EGVRSAPISILTEEDAPDSPPQDFSVKQLSGVTVKLSWQPP--LEPNGIILYYTVYVWNR 895
G+ S+ + +P ++ V+ + ++ LSW+ P +P Y +
Sbjct: 193 NGINSSRET--RNATTAHNPVRNLRVEAQTTSSISLSWEVPDGTDPQN-STYCVQCTGDG 249
Query: 896 SSLKTINVTETSLELSDLDYNVEYSAYVTASTRFGDGKTRSNIISFQTPEGAPSDPPKDV 955
+T N T+T + + L Y+ V DG S + T AP +P +++
Sbjct: 250 GRTETRNTTDTRVTVDGLGPGSLYTCSVWVEK---DGVNSS--VEIVTSATAP-NPVRNL 303
Query: 956 YYANLSSSSIILFWTPPSKPNGIIQYYSVYYRNTSGTFMQNFTLHEVTNDFDNMTVSTII 1015
++SSI L W P P+ Y V Y G T H N+TV
Sbjct: 304 TVEAQTNSSIALTWEVPDGPDPQNSTYGVEYTGDGGRAGTRSTAH------TNITV---- 353
Query: 1016 DKLTIFSYYTFWLTASTSVG-NGNKSSDIIEVYTDQDIPEGFVGNLTYESISSTAINVSW 1074
D+L Y F S VG NG SS T P V NL E+ ++++I + W
Sbjct: 354 DRLEPGCLYVF----SVWVGKNGINSSRETRNATTAPNP---VRNLHMETQTNSSIALCW 406
Query: 1075 VPPAQPNGLVF-YYVSLILQQTPRHVRPPLVTYERSIYFDNLEKYTDYILKITPSTEKGF 1133
P P + Y+V R T S+ + LE T Y + EK
Sbjct: 407 EVPDGPYPQDYTYWVEYTGDGGGTETRN---TTNTSVTAERLEPGTLYTFSVW--AEKNG 461
Query: 1134 SDTYTAQLYIKTEEDVPETSPIINTFKNLSSTSVLLSWDPPVKPNGAIISY--DLTLQGP 1191
+ + I T VP ++ ++ +++++ L W P P + SY +G
Sbjct: 462 ARGSRQNVSIST---VPNAVTSLSK-QDWTNSTIALRWTAPQGPGQSSYSYWVSWVREGM 517
Query: 1192 NENYSFITSDNYIILEELSPFTLYSFFAAARTRKGLGPSSILFFYTDESVPLAPPQNLTL 1251
+ + TS I L+EL +LY A + G +S L + AP + L
Sbjct: 518 TDPRTQSTSGTDITLKELEAGSLYHLTVWAERNEVRGYNSTL------TAATAPNEVTDL 571
Query: 1252 IN--CTSDFVWLKWSPSPLPGGIVKVY----SFKIHEH--ETDTIYYKNISGFKTEA--K 1301
N T + V L W P + VY + K H + + N + E K
Sbjct: 572 QNETQTKNSVMLWWKAPGDPHSQLYVYWVQWASKGHPRRGQDPQANWVNQTSRTNETWYK 631
Query: 1302 LVGLEPVSTYSIRVSAFTKVGNGNQFSNVVKFTTQESVPDVVQNMQCMATS 1352
+ LEP + Y+ FT N ++ + + PD V C++TS
Sbjct: 632 VEALEPGTLYN-----FTVWAERNDVASSTQSLCASTYPDTVTITSCVSTS 677
Score = 58.9 bits (141), Expect = 6e-08
Identities = 106/458 (23%), Positives = 166/458 (36%), Gaps = 62/458 (13%)
Query: 14 TSETQVDVSNVVPGTRYDITISSISTTYTSPVTRIVTTNVTKPGPPVFLAGERVGSAGIL 73
T+ T + V + PG Y ++ S +R T P L E ++ I
Sbjct: 168 TAHTNITVDGLEPGCLYAFSMWVGKNGINS--SRETRNATTAHNPVRNLRVEAQTTSSIS 225
Query: 74 LSWNTPPNPNGRIISYIVKYKEVCPWMQTVYTQVRSKPDSLEVLLTNLNPGTTYEIKVAA 133
LSW P + + +Y V+ T+ R+ D+ V + L PG+ Y V
Sbjct: 226 LSWEVPDGTDPQNSTYCVQCTG-----DGGRTETRNTTDT-RVTVDGLGPGSLYTCSVWV 279
Query: 134 ENSAGIGVFSDPFLFQTAESAPGKVVNLTVEAYNASAVKLIWYLPRQPNGKITSFKISVK 193
E GV S + T+ +AP V NLTVEA S++ L W +P P+ + +++ V+
Sbjct: 280 EKD---GVNSSVEIV-TSATAPNPVRNLTVEAQTNSSIALTWEVPDGPDPQNSTY--GVE 333
Query: 194 HARSGIVVKDVSIRVEDILTGKL-PECNENSESFLWSTA--SPSPTLGRVTPPS--RTTH 248
+ G S +I +L P C ++ S T T P+ R H
Sbjct: 334 YTGDGGRAGTRSTAHTNITVDRLEPGCLYVFSVWVGKNGINSSRETRNATTAPNPVRNLH 393
Query: 249 SSSTLTQNEISSVWKEP----------------------------ISFVVTHLRPYTTYL 280
T T + I+ W+ P S L P T Y
Sbjct: 394 ME-TQTNSSIALCWEVPDGPYPQDYTYWVEYTGDGGGTETRNTTNTSVTAERLEPGTLYT 452
Query: 281 FEVSAATTEA--GYIDSTIVRTPESVPEGPPQNCVTGNITGKSFSILWDPPTIVTGKFSY 338
F V A A + +I P +V Q+ T + ++ W P G+ SY
Sbjct: 453 FSVWAEKNGARGSRQNVSISTVPNAVTSLSKQDW-----TNSTIALRWTAPQ-GPGQSSY 506
Query: 339 RVELYGPSGRILD---NSTKDLKFAFTNLTPFTMYDVYIAAETSAGTGPKSNISVFTPPD 395
+ + D ST L ++Y + + AE + G S ++ T P+
Sbjct: 507 SYWVSWVREGMTDPRTQSTSGTDITLKELEAGSLYHLTVWAERNEVRGYNSTLTAATAPN 566
Query: 396 VPGAVFDLQLAEVESTQVRITWKKPRQPNGIINQYRVK 433
V DLQ V + WK P P+ + Y V+
Sbjct: 567 ---EVTDLQNETQTKNSVMLWWKAPGDPHSQLYVYWVQ 601
Score = 51.2 bits (121), Expect = 1e-05
Identities = 89/409 (21%), Positives = 142/409 (34%), Gaps = 67/409 (16%)
Query: 56 PGPPVFLAGERVGSAGILLSWNTPPNPNGRIISYIVKYKEVCPWMQTV----YTQVRSKP 111
P P L E ++ I LSW P + + +Y W+Q T+ R+
Sbjct: 30 PNPGRNLTVETQTTSSISLSWEVPDGLDSQNSNY---------WVQCTGDGGTTETRNTT 80
Query: 112 DSLEVLLTNLNPGTTYEIKVAAENSAGIGVFSDPFLFQTAESAPGKVVNLTVEAYNASAV 171
+ V + L PG+ Y V E GV S TA +AP V NL VEA S++
Sbjct: 81 -ATNVTVDGLGPGSLYTCSVWVEKD---GVNSSVGTVTTA-TAPNPVRNLRVEAQTNSSI 135
Query: 172 KLIWYLPRQPNGKITSFKISV----------KHARSGIVVKDV----------------- 204
L W +P P+ + +++ + A + I V +
Sbjct: 136 ALTWEVPDGPDPQNSTYGVEYTGDGGRAGTRSTAHTNITVDGLEPGCLYAFSMWVGKNGI 195
Query: 205 --SIRVEDILTGKLPECNENSESFLWSTASPSPTLGRVTPPSRTTH-------SSSTLTQ 255
S + T P N E+ S+ S S + T P +T+ T T+
Sbjct: 196 NSSRETRNATTAHNPVRNLRVEAQTTSSISLSWEVPDGTDPQNSTYCVQCTGDGGRTETR 255
Query: 256 NEISSVWKEPISFVVTHLRPYTTYLFEVSAATTEAGYIDSTIVRTPESVPEGPPQNCVTG 315
N + V L P + Y V E ++S++ + P +N
Sbjct: 256 NTTDT------RVTVDGLGPGSLYTCSV---WVEKDGVNSSVEIVTSATAPNPVRNLTVE 306
Query: 316 NITGKSFSILWDPPTIVTGKFS-YRVELYGPSGRILDNSTKDLKFAFTNLTPFTMYDVYI 374
T S ++ W+ P + S Y VE G GR ST L P + Y+
Sbjct: 307 AQTNSSIALTWEVPDGPDPQNSTYGVEYTGDGGRAGTRSTAHTNITVDRLEPGCL---YV 363
Query: 375 AAETSAGTGPKSNISVFTPPDVPGAVFDLQLAEVESTQVRITWKKPRQP 423
+ G S+ P V +L + ++ + + W+ P P
Sbjct: 364 FSVWVGKNGINSSRETRNATTAPNPVRNLHMETQTNSSIALCWEVPDGP 412
Score = 50.8 bits (120), Expect = 1e-05
Identities = 50/189 (26%), Positives = 79/189 (41%), Gaps = 16/189 (8%)
Query: 14 TSETQVDVSNVVPGTRYDITISSISTTYTSPVTRIVTTNVTKPGPPVFLAGERVGSAGIL 73
T+ T V + PGT Y T S + + +R + T P L+ + ++ I
Sbjct: 435 TTNTSVTAERLEPGTLY--TFSVWAEKNGARGSRQNVSISTVPNAVTSLSKQDWTNSTIA 492
Query: 74 LSWNTPPNPNGRIISYIVKYKEVCPWMQTVYTQVRSKPDS-LEVLLTNLNPGTTYEIKVA 132
L W P P SY V W++ T R++ S ++ L L G+ Y + V
Sbjct: 493 LRWTAPQGPGQSSYSYWVS------WVREGMTDPRTQSTSGTDITLKELEAGSLYHLTVW 546
Query: 133 AENSAGIGVFSDPFLFQTAESAPGKVVNLTVEAYNASAVKLIWYLPRQPNGKITSFKI-- 190
AE + G S TA +AP +V +L E ++V L W P P+ ++ + +
Sbjct: 547 AERNEVRGYNST----LTAATAPNEVTDLQNETQTKNSVMLWWKAPGDPHSQLYVYWVQW 602
Query: 191 -SVKHARSG 198
S H R G
Sbjct: 603 ASKGHPRRG 611
Score = 48.9 bits (115), Expect = 6e-05
Identities = 120/521 (23%), Positives = 194/521 (37%), Gaps = 70/521 (13%)
Query: 950 DPPKDVYYANLSSSSIILFWTPPSKPNGIIQYYSVYYRNTSGTFMQNFTLHEVTNDFDNM 1009
+P +++ ++SSI L W P+G+ S Y+ +G T + N
Sbjct: 31 NPGRNLTVETQTTSSISLSW---EVPDGLDSQNSNYWVQCTGD--------GGTTETRNT 79
Query: 1010 TVSTI-IDKLTIFSYYTFWLTASTSVGNGNKSSDIIEVYTDQDIPEGFVGNLTYESISST 1068
T + + +D L S YT S V +S + V T P V NL E+ +++
Sbjct: 80 TATNVTVDGLGPGSLYT----CSVWVEKDGVNSSVGTV-TTATAPNP-VRNLRVEAQTNS 133
Query: 1069 AINVSWVPPAQPNGLVFYYVSLILQQTPRHVRPPLVTYERSIYFDNLEKYTDYILKITPS 1128
+I ++W P P+ Y R T +I D LE P
Sbjct: 134 SIALTWEVPDGPDPQNSTYGVEYTGDGGR--AGTRSTAHTNITVDGLE----------PG 181
Query: 1129 TEKGFSDTYTAQLYIKTEEDVPETSPIINTFKNL-----SSTSVLLSWDPP--VKPNGAI 1181
FS + + I + + + N +NL +++S+ LSW+ P P +
Sbjct: 182 CLYAFS-MWVGKNGINSSRETRNATTAHNPVRNLRVEAQTTSSISLSWEVPDGTDPQNST 240
Query: 1182 ISYDLTLQGPNENYSFITSDNYIILEELSPFTLYSFFAAARTRKGLGPSSILFFYTDESV 1241
T G + T+D + ++ L P +LY+ + K G +S + T +
Sbjct: 241 YCVQCTGDG-GRTETRNTTDTRVTVDGLGPGSLYT--CSVWVEKD-GVNSSVEIVTSATA 296
Query: 1242 PLAPPQNLTLINCTSDFVWLKWSPSPLPGGIVKVYSFKIHEHETDTIYYKNISGFKTEAK 1301
P P +NLT+ T+ + L W P Y E+ D S T
Sbjct: 297 P-NPVRNLTVEAQTNSSIALTWEVPDGPDPQNSTYGV---EYTGDGGRAGTRSTAHTNIT 352
Query: 1302 LVGLEPVSTYSIRVSAFTKVG-NGNQFSNVVKFTTQESVPDVVQNMQCMATSWQSVLVKW 1360
+ LEP Y V VG NG S + T + P+ V+N+ + S+ + W
Sbjct: 353 VDRLEPGCLYVFSVW----VGKNGINSSRETRNAT--TAPNPVRNLHMETQTNSSIALCW 406
Query: 1361 DPPKKANGIITQYMV--------TVERNSTKVSPQDHMYTFIKLLANTSYVFKVRASTSA 1412
+ P Y V T RN+T S T +L T Y F V A +
Sbjct: 407 EVPDGPYPQDYTYWVEYTGDGGGTETRNTTNTS-----VTAERLEPGTLYTFSVWAEKNG 461
Query: 1413 GEGDESTCHVSTLPETVPSVPTNIAFSDVQSTSATLTWIRP 1453
G +ST+P V T+++ D +++ L W P
Sbjct: 462 ARGSRQNVSISTVPNAV----TSLSKQDWTNSTIALRWTAP 498
Score = 34.3 bits (77), Expect = 1.5
Identities = 73/308 (23%), Positives = 118/308 (38%), Gaps = 34/308 (11%)
Query: 1158 TFKNLSSTSVLLSWDPPVKPNGAIISY--DLTLQGPNENYSFITSDNYIILEELSPFTLY 1215
T + +++S+ LSW+ P + +Y T G T+ N + ++ L P +LY
Sbjct: 37 TVETQTTSSISLSWEVPDGLDSQNSNYWVQCTGDGGTTETRNTTATN-VTVDGLGPGSLY 95
Query: 1216 SFFAAARTRKGLGPSSILFFYTDESVPLAPPQNLTLINCTSDFVWLKWSPSPLPGGIVKV 1275
+ + K G +S + T + P P +NL + T+ + L W P
Sbjct: 96 T--CSVWVEKD-GVNSSVGTVTTATAP-NPVRNLRVEAQTNSSIALTWEVPDGPDPQNST 151
Query: 1276 YSFKIHEHETDTIYYKNISGFKTEAKLVGLEPVSTYSIRVSAFTKVG-NGNQFSNVVKFT 1334
Y E+ D S T + GLEP Y+ + VG NG S +
Sbjct: 152 YGV---EYTGDGGRAGTRSTAHTNITVDGLEPGCLYAFSMW----VGKNGINSSRETRNA 204
Query: 1335 TQESVPDVVQNMQCMATSWQSVLVKWDPPKKANGIITQYMV--------TVERNSTKVSP 1386
T P V+N++ A + S+ + W+ P + + Y V T RN+T
Sbjct: 205 TTAHNP--VRNLRVEAQTTSSISLSWEVPDGTDPQNSTYCVQCTGDGGRTETRNTT---- 258
Query: 1387 QDHMYTFIKLLANTSYVFKVRASTSAGEGDESTCHVSTLPETVPSVPTNIAFSDVQSTSA 1446
D T L + Y V +G S+ + T T P+ N+ ++S
Sbjct: 259 -DTRVTVDGLGPGSLYTCSVWVEK---DGVNSSVEIVT-SATAPNPVRNLTVEAQTNSSI 313
Query: 1447 TLTWIRPD 1454
LTW PD
Sbjct: 314 ALTWEVPD 321
>gi|18860902 protein tyrosine phosphatase, receptor type, K isoform b
[Homo sapiens]
Length = 1440
Score = 236 bits (603), Expect = 1e-61
Identities = 202/710 (28%), Positives = 310/710 (43%), Gaps = 98/710 (13%)
Query: 1627 KSSAEMIVTTLESAPKDPPNNMTFQKIPDEVTKFQLTFLPPSQPNGNIQVYQALV--YRE 1684
K S E I+ T E P P + Q E K L + P PNG I Y+ R
Sbjct: 476 KESEETIIQTDEDVPGPVPVK-SLQGTSFE-NKIFLNWKEPLDPNGIITQYEISYSSIRS 533
Query: 1685 DDPTAVQIHNLSIIQKTNTFVIAMLEGLKGGHTYNISVYAVNSAGAGPKVPMRITMDIKA 1744
DP + + L G TY + A G GP + +T +I A
Sbjct: 534 FDPAVPVAGPPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPATAINVTTNISA 593
Query: 1745 PARPKTKPTPIYDATGKLLVTSTTITIRMPICYYSDDHGPIKNVQVLVTE---------T 1795
P P + DA+ L T+TTIT+ + PI Q++V E
Sbjct: 594 PTLPDYEGV---DAS--LNETATTITVLLRPAQAKG--APISAYQIVVEELHPHRTKREA 646
Query: 1796 GAQHDGNVTKWYDAYFNKARPYFTNEGFPNPPCTEGKTKFSGNEEIYIIGADNACMIPGN 1855
GA V Y + PY+ P E G+ Y
Sbjct: 647 GAMECYQVPVTYQNAMSGGAPYYFAAELPPGNLPEPAPFTVGDNRTY------------- 693
Query: 1856 EDKICNGPLKPKKQYLFKFRATNIMGQFTDSD----------------YSDPVKTLGEGL 1899
N PL P+K Y F+A + + + T + DP K
Sbjct: 694 -QGFWNPPLAPRKGYNIYFQAMSSVEKETKTQCVRIATKAAATEEPEVIPDPAKQ----- 747
Query: 1900 SERTVEI--ILSVTLCILSIILLGTAIFAFARIRQKQKE--GGT-------YSPQDAEII 1948
++R V+I I + L + ++L+ I +++ +K+K+ G T + D
Sbjct: 748 TDRVVKIAGISAGILVFILLLLVVILIVKKSKLAKKRKDAMGNTRQEMTHMVNAMDRSYA 807
Query: 1949 D-TKLKLDQLITVADLELKD-----------ERLTRLLSYRKSI--------------KP 1982
D + L + +++ ++ + +RLL + +
Sbjct: 808 DQSTLHAEDPLSITFMDQHNFSPRYENHSATAESSRLLDVPRYLCEGTESPYQTGQLHPA 867
Query: 1983 ISKKSFLQHVEELCTNNNLKFQEEFSELPKFLQDLSSTDADLPWNRAKNRFPNIKPYNNN 2042
I LQH+ + T+++ F+EE+ + Q S A NRAKNR+ NI Y+++
Sbjct: 868 IRVADLLQHINLMKTSDSYGFKEEYESFFEG-QSASWDVAKKDQNRAKNRYGNIIAYDHS 926
Query: 2043 RVKLIADASVPGSDYINASYISGYLCPNEFIATQGPLPGTVGDFWRMVWETRAKTLVMLT 2102
RV L P SDYINA+YI GY P+ +IATQGP+ TV DFWRM+W+ ++ +VM+T
Sbjct: 927 RVILQPVEDDPSSDYINANYIDGYQRPSHYIATQGPVHETVYDFWRMIWQEQSACIVMVT 986
Query: 2103 QCFEKGRIRCHQYWPEDNKPVTVFGDIVITKLMEDVQIDWTIRDLKIERHG--DCMTVRQ 2160
E GR++C++YWP+D + V+GD +T + + ++ +R +ER G + V+Q
Sbjct: 987 NLVEVGRVKCYKYWPDDTE---VYGDFKVTCVEMEPLAEYVVRTFTLERRGYNEIREVKQ 1043
Query: 2161 CNFTAWPEHGVPENSAPLIHFVKLVRASRAHDTTPMIVHCSAGVGRTGVFIALDHLTQHI 2220
+FT WP+HGVP ++ L+ F++ V+ S P++VHCSAG GRTG +I +D +
Sbjct: 1044 FHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRTGCYIVIDIMLDMA 1103
Query: 2221 NDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLLSNKGSNQPIC 2270
VDIY V LRS R+ MVQ QYIF+H IL+ + P+C
Sbjct: 1104 EREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGETAIPVC 1153
Score = 105 bits (262), Expect = 5e-22
Identities = 84/277 (30%), Positives = 131/277 (47%), Gaps = 20/277 (7%)
Query: 1999 NNLKFQEEFSELPKFLQDLSSTD---ADLPWNRAKNRFPNIKPYNNNRVKLIADASVPGS 2055
N+ ++EF L L + D A LP N KNRF ++ P + LI S
Sbjct: 1170 NSSHLKDEFQTLNSVTPRLQAEDCSIACLPRNHDKNRFMDMLPPDRCLPFLIT-IDGESS 1228
Query: 2056 DYINASYISGYLCPNEFIATQGPLPGTVGDFWRMVWETRAKTLVMLTQC-FEKGRIRCHQ 2114
+YINA+ + Y P FI TQ PLP TV DFWR+V++ ++VML + +G C Q
Sbjct: 1229 NYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVDLSQG---CPQ 1285
Query: 2115 YWPEDNKPVTVFGDIVITKLMEDVQID-----WTIRDLKIERHGDCMTVRQCNFTAWPEH 2169
YWPE+ + +G I + + + D + I +L + G M V+Q + W H
Sbjct: 1286 YWPEEG--MLRYGPIQVECMSCSMDCDVINRIFRICNLTRPQEGYLM-VQQFQYLGWASH 1342
Query: 2170 ----GVPENSAPLIHFVKLVRASRAHDTTPMIVHCSAGVGRTGVFIALDHLTQHINDHDF 2225
G + LI V+ + I+HC G GR+G+F A+ + + + +
Sbjct: 1343 REVPGSKRSFLKLILQVEKWQEECEEGEGRTIIHCLNGGGRSGMFCAIGIVVEMVKRQNV 1402
Query: 2226 VDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLLSN 2262
VD++ V LR+ + MV+ QY F + L+ L +
Sbjct: 1403 VDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLES 1439
Score = 70.9 bits (172), Expect = 1e-11
Identities = 52/194 (26%), Positives = 89/194 (45%), Gaps = 27/194 (13%)
Query: 1113 DNLEKYTDYILKITPSTEKGFSDTYTAQLYIKTEEDVPETSPIINTFKNLSSTS----VL 1168
++L YT+ LK+ + +G ++ + I+T+EDVP P+ K+L TS +
Sbjct: 455 NHLPPYTNVSLKMILTNPEGRKES--EETIIQTDEDVPGPVPV----KSLQGTSFENKIF 508
Query: 1169 LSWDPPVKPNGAIISYDLT------------LQGPNENYSFITSDNYIILEELSPFTLYS 1216
L+W P+ PNG I Y+++ + GP + S + + + + L P T Y
Sbjct: 509 LNWKEPLDPNGIITQYEISYSSIRSFDPAVPVAGPPQTVSNLWNSTHHVFMHLHPGTTYQ 568
Query: 1217 FFAAARTRKGLGPSSILFFYTDESVPLAPPQN--LTLINCTSDFVWLKWSPSPLPGGIVK 1274
FF A T KG GP++ + T+ S P P +N T+ + + P+ G +
Sbjct: 569 FFIRASTVKGFGPATAINVTTNISAPTLPDYEGVDASLNETATTITVLLRPAQAKGAPIS 628
Query: 1275 VYSF---KIHEHET 1285
Y ++H H T
Sbjct: 629 AYQIVVEELHPHRT 642
Score = 53.5 bits (127), Expect = 2e-06
Identities = 86/384 (22%), Positives = 146/384 (38%), Gaps = 51/384 (13%)
Query: 633 TKYKMRVAASTHVGESSLSEEND-IFVRTSEDEPESSPQDVEVIDVTADEIRLKWSPPEK 691
T+Y++RV T GE + RT EP +P+ +++ ++ A I + W E
Sbjct: 357 TEYEIRVLL-TRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQARRIAVDW---ES 412
Query: 692 PNGIIIAYEVLYKNIDTLYMK--NTSTTDI----------ILRNLRPHTLYNISVRSYTR 739
I I Y + N S D ++ +L P+T N+S++
Sbjct: 413 LGYNITRCHTFNVTICYHYFRGHNESKADCLDMDPKAPQHVVNHLPPYT--NVSLKMILT 470
Query: 740 FGHGNQVSSLLSVRTSETVPDSAPENITYKNISSGEIELSFLPPSSPNGIIQKYTIYLKR 799
G + S ++T E VP P +I L++ P PNGII +Y I
Sbjct: 471 NPEGRKESEETIIQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSS 530
Query: 800 SN---------GNEERTINTTSLTQNIKV-LKKYTQYIIEVSASTLKGEGVRSAPISILT 849
G + N + T ++ + L T Y + AST+KG G +A I++ T
Sbjct: 531 IRSFDPAVPVAGPPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPATA-INVTT 589
Query: 850 EEDAPDSPPQ---DFSVKQLSGVTVKLSWQPPLEPNGIILYYTVYVWNRSSLKTINVTET 906
AP P D S+ + + T+ + +P I Y + V + ++ T
Sbjct: 590 NISAPTLPDYEGVDASLNE-TATTITVLLRPAQAKGAPISAYQIVV------EELHPHRT 642
Query: 907 SLELSDLDYNVEYSAYVTASTRFGDGKTRSNIISFQTPEGAPSDPPKDVYYANLSSSSII 966
E ++ Y VT G + E P + P+ + + +
Sbjct: 643 KREAGAMEC---YQVPVTYQNAMSGGAP-----YYFAAELPPGNLPEPAPFTVGDNRTYQ 694
Query: 967 LFWTPPSKPNGIIQYYSVYYRNTS 990
FW PP P + Y++Y++ S
Sbjct: 695 GFWNPPLAPR---KGYNIYFQAMS 715
Score = 50.4 bits (119), Expect = 2e-05
Identities = 54/187 (28%), Positives = 74/187 (39%), Gaps = 26/187 (13%)
Query: 269 VVTHLRPYTTYLFEVSAATTEAGY-IDSTIVRTPESVPEGPPQNCVTGNITGKSFSILW- 326
VV HL PYT ++ E + TI++T E VP P + G + W
Sbjct: 453 VVNHLPPYTNVSLKMILTNPEGRKESEETIIQTDEDVPGPVPVKSLQGTSFENKIFLNWK 512
Query: 327 ---DPPTIVTG---------KFSYRVELYGPSGRILDNSTKDLKFAFTNLTPFTMYDVYI 374
DP I+T F V + GP + + N F +L P T Y +I
Sbjct: 513 EPLDPNGIITQYEISYSSIRSFDPAVPVAGPP-QTVSNLWNSTHHVFMHLHPGTTYQFFI 571
Query: 375 AAETSAGTGP------KSNISVFTPPDVPGAVFDLQLAEVESTQVRITWKKPRQPNGI-I 427
A T G GP +NIS T PD G D L E +T + +P Q G I
Sbjct: 572 RASTVKGFGPATAINVTTNISAPTLPDYEGV--DASLNETATTITVLL--RPAQAKGAPI 627
Query: 428 NQYRVKV 434
+ Y++ V
Sbjct: 628 SAYQIVV 634
Score = 47.8 bits (112), Expect = 1e-04
Identities = 65/275 (23%), Positives = 109/275 (39%), Gaps = 41/275 (14%)
Query: 1206 LEELSPFTLYSFFAAARTRKGLG----PSSILFFYTDESVPLAPPQNLTLINCTSDFVWL 1261
L L P T Y TR G G P L T + P+ P+ L + + + +
Sbjct: 350 LWHLDPDTEYEI-RVLLTRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQARRIAV 408
Query: 1262 KWSPSPLPGGIVKVYSFKIHEHETDTIYYKNISGF-KTEAKLVGLEPVSTYSI--RVSAF 1318
W L I + ++F + TI Y G +++A + ++P + + + +
Sbjct: 409 DWES--LGYNITRCHTFNV------TICYHYFRGHNESKADCLDMDPKAPQHVVNHLPPY 460
Query: 1319 TKVG--------NGNQFSNVVKFTTQESVPDVVQNMQCMATSWQS-VLVKWDPPKKANGI 1369
T V G + S T E VP V TS+++ + + W P NGI
Sbjct: 461 TNVSLKMILTNPEGRKESEETIIQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPLDPNGI 520
Query: 1370 ITQYMVTVE--RNSTKVSP------------QDHMYTFIKLLANTSYVFKVRASTSAGEG 1415
ITQY ++ R+ P + F+ L T+Y F +RAST G G
Sbjct: 521 ITQYEISYSSIRSFDPAVPVAGPPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFG 580
Query: 1416 DESTCHVSTLPETVPSVPTNIAF-SDVQSTSATLT 1449
+ +V+T + P++P + + T+ T+T
Sbjct: 581 PATAINVTT-NISAPTLPDYEGVDASLNETATTIT 614
Score = 46.2 bits (108), Expect = 4e-04
Identities = 85/420 (20%), Positives = 161/420 (38%), Gaps = 37/420 (8%)
Query: 795 IYLKRSNGNEERTINTTSLTQN-------IKVLKKYTQYIIEVSASTLKGEGVRSAPISI 847
++L+R NG + T ++ ++ + K Q + + +G GV + I
Sbjct: 228 LWLQRRNGEDIPVAQTKNINHRRFAASFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLI 287
Query: 848 LTEEDAPDSPPQDFSVKQLSGVTVKLSWQPPLEPNGIILYYTVY-VWNRSSLKTINVTET 906
+ E P +PPQ V + + ++L+ + IIL Y + + S +T V
Sbjct: 288 VREPPRPIAPPQLLGVGP-TYLLIQLNANSIIGDGPIILKEVEYRMTSGSWTETHAVNAP 346
Query: 907 SLELSDLDYNVEYSAYVTASTRFGDGKT--RSNIISFQTPEGAPSDPPKDVYYANLSSSS 964
+ +L LD + EY V TR G+G T + +T P PK + A + +
Sbjct: 347 TYKLWHLDPDTEYEIRVLL-TRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQARR 405
Query: 965 IILFWTPPSKPNGIIQYYSVYYRNTSGTFMQNFTLHEVTNDFDNMTVSTIIDKLTIFSYY 1024
I + W S I + ++ F + D D +++ L ++
Sbjct: 406 IAVDW--ESLGYNITRCHTFNVTICYHYFRGHNESKADCLDMDPKAPQHVVNHLPPYTNV 463
Query: 1025 TFWLTASTSVGNGNKSSDIIEVYTDQDIPEGFVGNLTYESISSTA----INVSWVPPAQP 1080
+ + + G K S+ + TD+D+P G + +S+ T+ I ++W P P
Sbjct: 464 SLKMILTNP--EGRKESEETIIQTDEDVP----GPVPVKSLQGTSFENKIFLNWKEPLDP 517
Query: 1081 NGLVFYYVSLILQQTPRHVRP--PLVTYERSI---------YFDNLEKYTDYILKITPST 1129
NG++ Y I + R P P+ +++ F +L T Y I ST
Sbjct: 518 NGIITQYE--ISYSSIRSFDPAVPVAGPPQTVSNLWNSTHHVFMHLHPGTTYQFFIRAST 575
Query: 1130 EKGFSDTYTAQLYIKTEEDVPETSPIINTFKNLSSTSVLLSWDPPVKPNGAIISYDLTLQ 1189
KGF + ++ N ++T++ + P I +Y + ++
Sbjct: 576 VKGFGPATAINVTTNISAPTLPDYEGVDASLNETATTITVLLRPAQAKGAPISAYQIVVE 635
Score = 42.7 bits (99), Expect = 0.004
Identities = 82/393 (20%), Positives = 140/393 (35%), Gaps = 50/393 (12%)
Query: 735 RSYTRFGHGNQVSSLLSVRTSETVPDSAPENITYKNISSGEIELSFLPPSSPNGIIQKYT 794
R T+ G+ VS+ + E AP + + I+L+ II K
Sbjct: 269 RCVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLLIQLNANSIIGDGPIILKEV 328
Query: 795 IYLKRSNGNEERTINTTSLTQNIKVLKKYTQYIIEVSASTLK--GEGVRSAPISILTEED 852
Y + ++G+ T + T + L T+Y I V + G G+ P+ T+
Sbjct: 329 EY-RMTSGSWTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGPPLITRTKCA 387
Query: 853 APDSPPQDFSVKQLSGVTVKLSWQPPLEPNGIILYYTVYVWNRSSLKTINVT-------- 904
P P+ + ++ + + W+ +N + T NVT
Sbjct: 388 EPMRTPKTLKIAEIQARRIAVDWES-------------LGYNITRCHTFNVTICYHYFRG 434
Query: 905 --ETSLELSDLDYNVEYSA------YVTASTRF----GDGKTRSNIISFQTPEGAPSDPP 952
E+ + D+D Y S + +G+ S QT E P P
Sbjct: 435 HNESKADCLDMDPKAPQHVVNHLPPYTNVSLKMILTNPEGRKESEETIIQTDEDVPGPVP 494
Query: 953 KDVYYANLSSSSIILFWTPPSKPNGIIQYYSVYYRNTSGTFMQNFTLHEVTNDFDNMTVS 1012
+ I L W P PNGII Y + Y ++ +F + N+ S
Sbjct: 495 VKSLQGTSFENKIFLNWKEPLDPNGIITQYEISY-SSIRSFDPAVPVAGPPQTVSNLWNS 553
Query: 1013 T--IIDKLTIFSYYTFWLTASTSVGNGNKSSDIIEVYTDQDIP-----EGFVGNLTYESI 1065
T + L + Y F++ AST G G ++ I V T+ P EG +L +
Sbjct: 554 THHVFMHLHPGTTYQFFIRASTVKGFGPATA--INVTTNISAPTLPDYEGVDASLNETAT 611
Query: 1066 SSTAINVSWVPPAQPNGLVFYYVSLILQQTPRH 1098
+ T + + PAQ G +++++ H
Sbjct: 612 TITVL----LRPAQAKGAPISAYQIVVEELHPH 640
Score = 41.2 bits (95), Expect = 0.012
Identities = 39/149 (26%), Positives = 61/149 (40%), Gaps = 19/149 (12%)
Query: 11 FIGTSETQVDVSNVVPGTRYDI-------TISSISTTYTSPVTR------IVTTNVTKPG 57
F G +E++ D ++ P + T S+ T+P R I+ T+ PG
Sbjct: 432 FRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLKMILTNPEGRKESEETIIQTDEDVPG 491
Query: 58 P-PVFLAGERVGSAGILLSWNTPPNPNGRIISYIVKYKEVCPWMQTVYT-----QVRSKP 111
P PV I L+W P +PNG I Y + Y + + V V +
Sbjct: 492 PVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSSIRSFDPAVPVAGPPQTVSNLW 551
Query: 112 DSLEVLLTNLNPGTTYEIKVAAENSAGIG 140
+S + +L+PGTTY+ + A G G
Sbjct: 552 NSTHHVFMHLHPGTTYQFFIRASTVKGFG 580
Score = 40.8 bits (94), Expect = 0.016
Identities = 26/85 (30%), Positives = 38/85 (44%), Gaps = 3/85 (3%)
Query: 350 LDNSTKDLKFAFTNLTPFTMYDVYIAAETSAGTGPKSNISVFTPPDVPGAV--FDLQLAE 407
LD K + +L P+T + + G + T DVPG V LQ
Sbjct: 443 LDMDPKAPQHVVNHLPPYTNVSLKMILTNPEGRKESEETIIQTDEDVPGPVPVKSLQGTS 502
Query: 408 VESTQVRITWKKPRQPNGIINQYRV 432
E+ ++ + WK+P PNGII QY +
Sbjct: 503 FEN-KIFLNWKEPLDPNGIITQYEI 526
Score = 38.1 bits (87), Expect = 0.10
Identities = 54/222 (24%), Positives = 83/222 (37%), Gaps = 53/222 (23%)
Query: 111 PDSLEVLLTNLNPGTTYEIKVAAENSAGIGVFSDPFLFQTAESAPGKVVNLTVEAYN-AS 169
P + + ++ +L P T +K+ N G S+ + QT E PG V +++ + +
Sbjct: 447 PKAPQHVVNHLPPYTNVSLKMILTNPEGRKE-SEETIIQTDEDVPGPVPVKSLQGTSFEN 505
Query: 170 AVKLIWYLPRQPNGKITSFKISVKHARSGIVVKDVSIRVEDILTGKLPECNENSESFLWS 229
+ L W P PNG IT ++IS RS +
Sbjct: 506 KIFLNWKEPLDPNGIITQYEISYSSIRS------------------------------FD 535
Query: 230 TASPSPTLGRVTPPSRTTHSSSTLTQNEISSVWKEPISFVVTHLRPYTTYLFEVSAATTE 289
A P V P +T +S++W V HL P TTY F + A+T +
Sbjct: 536 PAVP------VAGPPQT-----------VSNLWNS-THHVFMHLHPGTTYQFFIRASTVK 577
Query: 290 A-GYIDSTIVRTPESVPEGPPQNCVTG--NITGKSFSILWDP 328
G + V T S P P V N T + ++L P
Sbjct: 578 GFGPATAINVTTNISAPTLPDYEGVDASLNETATTITVLLRP 619
Score = 37.7 bits (86), Expect = 0.13
Identities = 62/299 (20%), Positives = 110/299 (36%), Gaps = 35/299 (11%)
Query: 523 DIAAEQLSYVIRRLVPFTEHMISVSAFTIMGEGPPTVLSVRTRQQVPSSIKIINYKNIS- 581
D+ + +V+ L P+T + + G ++T + VP + + + + S
Sbjct: 444 DMDPKAPQHVVNHLPPYTNVSLKMILTNPEGRKESEETIIQTDEDVPGPVPVKSLQGTSF 503
Query: 582 SSSILLYWDPPEYPNGKITHYTI-YAMELDTNRAFQIT----TIDNSF-----LITGLKK 631
+ I L W P PNG IT Y I Y+ + A + T+ N + + L
Sbjct: 504 ENKIFLNWKEPLDPNGIITQYEISYSSIRSFDPAVPVAGPPQTVSNLWNSTHHVFMHLHP 563
Query: 632 YTKYKMRVAASTHVGESSLSEENDIFVRTSEDEPESSPQDVEVIDVTADEIRLKWSPPEK 691
T Y+ + AST G + N ++ P+ D ++ TA I + P +
Sbjct: 564 GTTYQFFIRASTVKGFGPATAINVTTNISAPTLPDYEGVDAS-LNETATTITVLLRPAQA 622
Query: 692 PNGIIIAYEVLYKNIDTLYMKNTSTTDIILRNLRPHTLYNISVRSYTRFGHGNQ---VSS 748
I AY+++ ++ L+ T R Y + V G +
Sbjct: 623 KGAPISAYQIV---VEELHPHRTK------REAGAMECYQVPVTYQNAMSGGAPYYFAAE 673
Query: 749 LLSVRTSETVPDSAPENITYKNISSGEIELSFLPPSSPNGIIQKYTIYLKRSNGNEERT 807
L E P + +N TY+ + PP +P + Y IY + + E+ T
Sbjct: 674 LPPGNLPEPAPFTVGDNRTYQGF--------WNPPLAPR---KGYNIYFQAMSSVEKET 721
Score = 33.5 bits (75), Expect = 2.5
Identities = 41/193 (21%), Positives = 64/193 (33%), Gaps = 29/193 (15%)
Query: 1205 ILEELSPFTLYSFFAAARTRKGLGPSSILFFYTDESVPLAPPQNLTLINCTSDFVWLKWS 1264
++ L P+T S +G S TDE VP P + ++L W
Sbjct: 453 VVNHLPPYTNVSLKMILTNPEGRKESEETIIQTDEDVPGPVPVKSLQGTSFENKIFLNWK 512
Query: 1265 PSPLPGGIVKVYSFKIHEHETDTIYYKNISGFKTEAKLVG------------------LE 1306
P GI+ Y I Y +I F + G L
Sbjct: 513 EPLDPNGIITQYE----------ISYSSIRSFDPAVPVAGPPQTVSNLWNSTHHVFMHLH 562
Query: 1307 PVSTYSIRVSAFTKVGNGNQFS-NVVKFTTQESVPDVVQNMQCMATSWQSVLVKWDPPKK 1365
P +TY + A T G G + NV + ++PD + + ++ V P +
Sbjct: 563 PGTTYQFFIRASTVKGFGPATAINVTTNISAPTLPDYEGVDASLNETATTITVLLRPAQA 622
Query: 1366 ANGIITQYMVTVE 1378
I+ Y + VE
Sbjct: 623 KGAPISAYQIVVE 635
>gi|208431815 protein tyrosine phosphatase, receptor type, K isoform a
[Homo sapiens]
Length = 1446
Score = 230 bits (586), Expect = 1e-59
Identities = 202/716 (28%), Positives = 310/716 (43%), Gaps = 104/716 (14%)
Query: 1627 KSSAEMIVTTLESAPKDPPNNMTFQKIPDEVTKFQLTFLPPSQPNGNIQVYQALV--YRE 1684
K S E I+ T E P P + Q E K L + P PNG I Y+ R
Sbjct: 476 KESEETIIQTDEDVPGPVPVK-SLQGTSFE-NKIFLNWKEPLDPNGIITQYEISYSSIRS 533
Query: 1685 DDPTAVQIHNLSIIQKTNTFVIAMLEGLKGGHTYNISVYAVNSAGAGPKVPMRITMDIKA 1744
DP + + L G TY + A G GP + +T +I A
Sbjct: 534 FDPAVPVAGPPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPATAINVTTNISA 593
Query: 1745 PARPKTKPTPIYDATGKLLVTSTTITIRMPICYYSDDHGPIKNVQVLVTE---------T 1795
P P + DA+ L T+TTIT+ + PI Q++V E
Sbjct: 594 PTLPDYEGV---DAS--LNETATTITVLLRPAQAKG--APISAYQIVVEELHPHRTKREA 646
Query: 1796 GAQHDGNVTKWYDAYFNKARPYFTNEGFPNPPCTEGKTKFSGNEEIYIIGADNACMIPGN 1855
GA V Y + PY+ P E G+ Y
Sbjct: 647 GAMECYQVPVTYQNAMSGGAPYYFAAELPPGNLPEPAPFTVGDNRTY------------- 693
Query: 1856 EDKICNGPLKPKKQYLFKFRATNIMGQFTDSD----------------YSDPVKTLGEGL 1899
N PL P+K Y F+A + + + T + DP K
Sbjct: 694 -QGFWNPPLAPRKGYNIYFQAMSSVEKETKTQCVRIATKAAATEEPEVIPDPAKQ----- 747
Query: 1900 SERTVEI--ILSVTLCILSIILLGTAIFAFARIRQKQKE--GGT-------YSPQDAEII 1948
++R V+I I + L + ++L+ I +++ +K+K+ G T + D
Sbjct: 748 TDRVVKIAGISAGILVFILLLLVVILIVKKSKLAKKRKDAMGNTRQEMTHMVNAMDRSYA 807
Query: 1949 D-TKLKLDQLITVADLELKD-----------ERLTRLLSYRKSI--------------KP 1982
D + L + +++ ++ + +RLL + +
Sbjct: 808 DQSTLHAEDPLSITFMDQHNFSPRYENHSATAESSRLLDVPRYLCEGTESPYQTGQLHPA 867
Query: 1983 ISKKSFLQHVEELCTNNNLKFQEEFSELPKFLQDLSSTDADLPWNRAKNRFPNIKPYNNN 2042
I LQH+ + T+++ F+EE+ + Q S A NRAKNR+ NI Y+++
Sbjct: 868 IRVADLLQHINLMKTSDSYGFKEEYESFFEG-QSASWDVAKKDQNRAKNRYGNIIAYDHS 926
Query: 2043 RVKLIADASVPGSDYINASYIS------GYLCPNEFIATQGPLPGTVGDFWRMVWETRAK 2096
RV L P SDYINA+YI GY P+ +IATQGP+ TV DFWRM+W+ ++
Sbjct: 927 RVILQPVEDDPSSDYINANYIDIWLYRDGYQRPSHYIATQGPVHETVYDFWRMIWQEQSA 986
Query: 2097 TLVMLTQCFEKGRIRCHQYWPEDNKPVTVFGDIVITKLMEDVQIDWTIRDLKIERHG--D 2154
+VM+T E GR++C++YWP+D + V+GD +T + + ++ +R +ER G +
Sbjct: 987 CIVMVTNLVEVGRVKCYKYWPDDTE---VYGDFKVTCVEMEPLAEYVVRTFTLERRGYNE 1043
Query: 2155 CMTVRQCNFTAWPEHGVPENSAPLIHFVKLVRASRAHDTTPMIVHCSAGVGRTGVFIALD 2214
V+Q +FT WP+HGVP ++ L+ F++ V+ S P++VHCSAG GRTG +I +D
Sbjct: 1044 IREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRTGCYIVID 1103
Query: 2215 HLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLLSNKGSNQPIC 2270
+ VDIY V LRS R+ MVQ QYIF+H IL+ + P+C
Sbjct: 1104 IMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGETAIPVC 1159
Score = 105 bits (262), Expect = 5e-22
Identities = 84/277 (30%), Positives = 131/277 (47%), Gaps = 20/277 (7%)
Query: 1999 NNLKFQEEFSELPKFLQDLSSTD---ADLPWNRAKNRFPNIKPYNNNRVKLIADASVPGS 2055
N+ ++EF L L + D A LP N KNRF ++ P + LI S
Sbjct: 1176 NSSHLKDEFQTLNSVTPRLQAEDCSIACLPRNHDKNRFMDMLPPDRCLPFLIT-IDGESS 1234
Query: 2056 DYINASYISGYLCPNEFIATQGPLPGTVGDFWRMVWETRAKTLVMLTQC-FEKGRIRCHQ 2114
+YINA+ + Y P FI TQ PLP TV DFWR+V++ ++VML + +G C Q
Sbjct: 1235 NYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVDLSQG---CPQ 1291
Query: 2115 YWPEDNKPVTVFGDIVITKLMEDVQID-----WTIRDLKIERHGDCMTVRQCNFTAWPEH 2169
YWPE+ + +G I + + + D + I +L + G M V+Q + W H
Sbjct: 1292 YWPEEG--MLRYGPIQVECMSCSMDCDVINRIFRICNLTRPQEGYLM-VQQFQYLGWASH 1348
Query: 2170 ----GVPENSAPLIHFVKLVRASRAHDTTPMIVHCSAGVGRTGVFIALDHLTQHINDHDF 2225
G + LI V+ + I+HC G GR+G+F A+ + + + +
Sbjct: 1349 REVPGSKRSFLKLILQVEKWQEECEEGEGRTIIHCLNGGGRSGMFCAIGIVVEMVKRQNV 1408
Query: 2226 VDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLLSN 2262
VD++ V LR+ + MV+ QY F + L+ L +
Sbjct: 1409 VDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLES 1445
Score = 70.9 bits (172), Expect = 1e-11
Identities = 52/194 (26%), Positives = 89/194 (45%), Gaps = 27/194 (13%)
Query: 1113 DNLEKYTDYILKITPSTEKGFSDTYTAQLYIKTEEDVPETSPIINTFKNLSSTS----VL 1168
++L YT+ LK+ + +G ++ + I+T+EDVP P+ K+L TS +
Sbjct: 455 NHLPPYTNVSLKMILTNPEGRKES--EETIIQTDEDVPGPVPV----KSLQGTSFENKIF 508
Query: 1169 LSWDPPVKPNGAIISYDLT------------LQGPNENYSFITSDNYIILEELSPFTLYS 1216
L+W P+ PNG I Y+++ + GP + S + + + + L P T Y
Sbjct: 509 LNWKEPLDPNGIITQYEISYSSIRSFDPAVPVAGPPQTVSNLWNSTHHVFMHLHPGTTYQ 568
Query: 1217 FFAAARTRKGLGPSSILFFYTDESVPLAPPQN--LTLINCTSDFVWLKWSPSPLPGGIVK 1274
FF A T KG GP++ + T+ S P P +N T+ + + P+ G +
Sbjct: 569 FFIRASTVKGFGPATAINVTTNISAPTLPDYEGVDASLNETATTITVLLRPAQAKGAPIS 628
Query: 1275 VYSF---KIHEHET 1285
Y ++H H T
Sbjct: 629 AYQIVVEELHPHRT 642
Score = 53.5 bits (127), Expect = 2e-06
Identities = 86/384 (22%), Positives = 146/384 (38%), Gaps = 51/384 (13%)
Query: 633 TKYKMRVAASTHVGESSLSEEND-IFVRTSEDEPESSPQDVEVIDVTADEIRLKWSPPEK 691
T+Y++RV T GE + RT EP +P+ +++ ++ A I + W E
Sbjct: 357 TEYEIRVLL-TRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQARRIAVDW---ES 412
Query: 692 PNGIIIAYEVLYKNIDTLYMK--NTSTTDI----------ILRNLRPHTLYNISVRSYTR 739
I I Y + N S D ++ +L P+T N+S++
Sbjct: 413 LGYNITRCHTFNVTICYHYFRGHNESKADCLDMDPKAPQHVVNHLPPYT--NVSLKMILT 470
Query: 740 FGHGNQVSSLLSVRTSETVPDSAPENITYKNISSGEIELSFLPPSSPNGIIQKYTIYLKR 799
G + S ++T E VP P +I L++ P PNGII +Y I
Sbjct: 471 NPEGRKESEETIIQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSS 530
Query: 800 SN---------GNEERTINTTSLTQNIKV-LKKYTQYIIEVSASTLKGEGVRSAPISILT 849
G + N + T ++ + L T Y + AST+KG G +A I++ T
Sbjct: 531 IRSFDPAVPVAGPPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPATA-INVTT 589
Query: 850 EEDAPDSPPQ---DFSVKQLSGVTVKLSWQPPLEPNGIILYYTVYVWNRSSLKTINVTET 906
AP P D S+ + + T+ + +P I Y + V + ++ T
Sbjct: 590 NISAPTLPDYEGVDASLNE-TATTITVLLRPAQAKGAPISAYQIVV------EELHPHRT 642
Query: 907 SLELSDLDYNVEYSAYVTASTRFGDGKTRSNIISFQTPEGAPSDPPKDVYYANLSSSSII 966
E ++ Y VT G + E P + P+ + + +
Sbjct: 643 KREAGAMEC---YQVPVTYQNAMSGGAP-----YYFAAELPPGNLPEPAPFTVGDNRTYQ 694
Query: 967 LFWTPPSKPNGIIQYYSVYYRNTS 990
FW PP P + Y++Y++ S
Sbjct: 695 GFWNPPLAPR---KGYNIYFQAMS 715
Score = 50.4 bits (119), Expect = 2e-05
Identities = 54/187 (28%), Positives = 74/187 (39%), Gaps = 26/187 (13%)
Query: 269 VVTHLRPYTTYLFEVSAATTEAGY-IDSTIVRTPESVPEGPPQNCVTGNITGKSFSILW- 326
VV HL PYT ++ E + TI++T E VP P + G + W
Sbjct: 453 VVNHLPPYTNVSLKMILTNPEGRKESEETIIQTDEDVPGPVPVKSLQGTSFENKIFLNWK 512
Query: 327 ---DPPTIVTG---------KFSYRVELYGPSGRILDNSTKDLKFAFTNLTPFTMYDVYI 374
DP I+T F V + GP + + N F +L P T Y +I
Sbjct: 513 EPLDPNGIITQYEISYSSIRSFDPAVPVAGPP-QTVSNLWNSTHHVFMHLHPGTTYQFFI 571
Query: 375 AAETSAGTGP------KSNISVFTPPDVPGAVFDLQLAEVESTQVRITWKKPRQPNGI-I 427
A T G GP +NIS T PD G D L E +T + +P Q G I
Sbjct: 572 RASTVKGFGPATAINVTTNISAPTLPDYEGV--DASLNETATTITVLL--RPAQAKGAPI 627
Query: 428 NQYRVKV 434
+ Y++ V
Sbjct: 628 SAYQIVV 634
Score = 47.8 bits (112), Expect = 1e-04
Identities = 65/275 (23%), Positives = 109/275 (39%), Gaps = 41/275 (14%)
Query: 1206 LEELSPFTLYSFFAAARTRKGLG----PSSILFFYTDESVPLAPPQNLTLINCTSDFVWL 1261
L L P T Y TR G G P L T + P+ P+ L + + + +
Sbjct: 350 LWHLDPDTEYEI-RVLLTRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQARRIAV 408
Query: 1262 KWSPSPLPGGIVKVYSFKIHEHETDTIYYKNISGF-KTEAKLVGLEPVSTYSI--RVSAF 1318
W L I + ++F + TI Y G +++A + ++P + + + +
Sbjct: 409 DWES--LGYNITRCHTFNV------TICYHYFRGHNESKADCLDMDPKAPQHVVNHLPPY 460
Query: 1319 TKVG--------NGNQFSNVVKFTTQESVPDVVQNMQCMATSWQS-VLVKWDPPKKANGI 1369
T V G + S T E VP V TS+++ + + W P NGI
Sbjct: 461 TNVSLKMILTNPEGRKESEETIIQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPLDPNGI 520
Query: 1370 ITQYMVTVE--RNSTKVSP------------QDHMYTFIKLLANTSYVFKVRASTSAGEG 1415
ITQY ++ R+ P + F+ L T+Y F +RAST G G
Sbjct: 521 ITQYEISYSSIRSFDPAVPVAGPPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFG 580
Query: 1416 DESTCHVSTLPETVPSVPTNIAF-SDVQSTSATLT 1449
+ +V+T + P++P + + T+ T+T
Sbjct: 581 PATAINVTT-NISAPTLPDYEGVDASLNETATTIT 614
Score = 46.2 bits (108), Expect = 4e-04
Identities = 85/420 (20%), Positives = 161/420 (38%), Gaps = 37/420 (8%)
Query: 795 IYLKRSNGNEERTINTTSLTQN-------IKVLKKYTQYIIEVSASTLKGEGVRSAPISI 847
++L+R NG + T ++ ++ + K Q + + +G GV + I
Sbjct: 228 LWLQRRNGEDIPVAQTKNINHRRFAASFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLI 287
Query: 848 LTEEDAPDSPPQDFSVKQLSGVTVKLSWQPPLEPNGIILYYTVY-VWNRSSLKTINVTET 906
+ E P +PPQ V + + ++L+ + IIL Y + + S +T V
Sbjct: 288 VREPPRPIAPPQLLGVGP-TYLLIQLNANSIIGDGPIILKEVEYRMTSGSWTETHAVNAP 346
Query: 907 SLELSDLDYNVEYSAYVTASTRFGDGKT--RSNIISFQTPEGAPSDPPKDVYYANLSSSS 964
+ +L LD + EY V TR G+G T + +T P PK + A + +
Sbjct: 347 TYKLWHLDPDTEYEIRVLL-TRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQARR 405
Query: 965 IILFWTPPSKPNGIIQYYSVYYRNTSGTFMQNFTLHEVTNDFDNMTVSTIIDKLTIFSYY 1024
I + W S I + ++ F + D D +++ L ++
Sbjct: 406 IAVDW--ESLGYNITRCHTFNVTICYHYFRGHNESKADCLDMDPKAPQHVVNHLPPYTNV 463
Query: 1025 TFWLTASTSVGNGNKSSDIIEVYTDQDIPEGFVGNLTYESISSTA----INVSWVPPAQP 1080
+ + + G K S+ + TD+D+P G + +S+ T+ I ++W P P
Sbjct: 464 SLKMILTNP--EGRKESEETIIQTDEDVP----GPVPVKSLQGTSFENKIFLNWKEPLDP 517
Query: 1081 NGLVFYYVSLILQQTPRHVRP--PLVTYERSI---------YFDNLEKYTDYILKITPST 1129
NG++ Y I + R P P+ +++ F +L T Y I ST
Sbjct: 518 NGIITQYE--ISYSSIRSFDPAVPVAGPPQTVSNLWNSTHHVFMHLHPGTTYQFFIRAST 575
Query: 1130 EKGFSDTYTAQLYIKTEEDVPETSPIINTFKNLSSTSVLLSWDPPVKPNGAIISYDLTLQ 1189
KGF + ++ N ++T++ + P I +Y + ++
Sbjct: 576 VKGFGPATAINVTTNISAPTLPDYEGVDASLNETATTITVLLRPAQAKGAPISAYQIVVE 635
Score = 42.7 bits (99), Expect = 0.004
Identities = 82/393 (20%), Positives = 140/393 (35%), Gaps = 50/393 (12%)
Query: 735 RSYTRFGHGNQVSSLLSVRTSETVPDSAPENITYKNISSGEIELSFLPPSSPNGIIQKYT 794
R T+ G+ VS+ + E AP + + I+L+ II K
Sbjct: 269 RCVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLLIQLNANSIIGDGPIILKEV 328
Query: 795 IYLKRSNGNEERTINTTSLTQNIKVLKKYTQYIIEVSASTLK--GEGVRSAPISILTEED 852
Y + ++G+ T + T + L T+Y I V + G G+ P+ T+
Sbjct: 329 EY-RMTSGSWTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGPPLITRTKCA 387
Query: 853 APDSPPQDFSVKQLSGVTVKLSWQPPLEPNGIILYYTVYVWNRSSLKTINVT-------- 904
P P+ + ++ + + W+ +N + T NVT
Sbjct: 388 EPMRTPKTLKIAEIQARRIAVDWES-------------LGYNITRCHTFNVTICYHYFRG 434
Query: 905 --ETSLELSDLDYNVEYSA------YVTASTRF----GDGKTRSNIISFQTPEGAPSDPP 952
E+ + D+D Y S + +G+ S QT E P P
Sbjct: 435 HNESKADCLDMDPKAPQHVVNHLPPYTNVSLKMILTNPEGRKESEETIIQTDEDVPGPVP 494
Query: 953 KDVYYANLSSSSIILFWTPPSKPNGIIQYYSVYYRNTSGTFMQNFTLHEVTNDFDNMTVS 1012
+ I L W P PNGII Y + Y ++ +F + N+ S
Sbjct: 495 VKSLQGTSFENKIFLNWKEPLDPNGIITQYEISY-SSIRSFDPAVPVAGPPQTVSNLWNS 553
Query: 1013 T--IIDKLTIFSYYTFWLTASTSVGNGNKSSDIIEVYTDQDIP-----EGFVGNLTYESI 1065
T + L + Y F++ AST G G ++ I V T+ P EG +L +
Sbjct: 554 THHVFMHLHPGTTYQFFIRASTVKGFGPATA--INVTTNISAPTLPDYEGVDASLNETAT 611
Query: 1066 SSTAINVSWVPPAQPNGLVFYYVSLILQQTPRH 1098
+ T + + PAQ G +++++ H
Sbjct: 612 TITVL----LRPAQAKGAPISAYQIVVEELHPH 640
Score = 41.2 bits (95), Expect = 0.012
Identities = 39/149 (26%), Positives = 61/149 (40%), Gaps = 19/149 (12%)
Query: 11 FIGTSETQVDVSNVVPGTRYDI-------TISSISTTYTSPVTR------IVTTNVTKPG 57
F G +E++ D ++ P + T S+ T+P R I+ T+ PG
Sbjct: 432 FRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLKMILTNPEGRKESEETIIQTDEDVPG 491
Query: 58 P-PVFLAGERVGSAGILLSWNTPPNPNGRIISYIVKYKEVCPWMQTVYT-----QVRSKP 111
P PV I L+W P +PNG I Y + Y + + V V +
Sbjct: 492 PVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSSIRSFDPAVPVAGPPQTVSNLW 551
Query: 112 DSLEVLLTNLNPGTTYEIKVAAENSAGIG 140
+S + +L+PGTTY+ + A G G
Sbjct: 552 NSTHHVFMHLHPGTTYQFFIRASTVKGFG 580
Score = 40.8 bits (94), Expect = 0.016
Identities = 26/85 (30%), Positives = 38/85 (44%), Gaps = 3/85 (3%)
Query: 350 LDNSTKDLKFAFTNLTPFTMYDVYIAAETSAGTGPKSNISVFTPPDVPGAV--FDLQLAE 407
LD K + +L P+T + + G + T DVPG V LQ
Sbjct: 443 LDMDPKAPQHVVNHLPPYTNVSLKMILTNPEGRKESEETIIQTDEDVPGPVPVKSLQGTS 502
Query: 408 VESTQVRITWKKPRQPNGIINQYRV 432
E+ ++ + WK+P PNGII QY +
Sbjct: 503 FEN-KIFLNWKEPLDPNGIITQYEI 526
Score = 38.1 bits (87), Expect = 0.10
Identities = 54/222 (24%), Positives = 83/222 (37%), Gaps = 53/222 (23%)
Query: 111 PDSLEVLLTNLNPGTTYEIKVAAENSAGIGVFSDPFLFQTAESAPGKVVNLTVEAYN-AS 169
P + + ++ +L P T +K+ N G S+ + QT E PG V +++ + +
Sbjct: 447 PKAPQHVVNHLPPYTNVSLKMILTNPEGRKE-SEETIIQTDEDVPGPVPVKSLQGTSFEN 505
Query: 170 AVKLIWYLPRQPNGKITSFKISVKHARSGIVVKDVSIRVEDILTGKLPECNENSESFLWS 229
+ L W P PNG IT ++IS RS +
Sbjct: 506 KIFLNWKEPLDPNGIITQYEISYSSIRS------------------------------FD 535
Query: 230 TASPSPTLGRVTPPSRTTHSSSTLTQNEISSVWKEPISFVVTHLRPYTTYLFEVSAATTE 289
A P V P +T +S++W V HL P TTY F + A+T +
Sbjct: 536 PAVP------VAGPPQT-----------VSNLWNS-THHVFMHLHPGTTYQFFIRASTVK 577
Query: 290 A-GYIDSTIVRTPESVPEGPPQNCVTG--NITGKSFSILWDP 328
G + V T S P P V N T + ++L P
Sbjct: 578 GFGPATAINVTTNISAPTLPDYEGVDASLNETATTITVLLRP 619
Score = 37.7 bits (86), Expect = 0.13
Identities = 62/299 (20%), Positives = 110/299 (36%), Gaps = 35/299 (11%)
Query: 523 DIAAEQLSYVIRRLVPFTEHMISVSAFTIMGEGPPTVLSVRTRQQVPSSIKIINYKNIS- 581
D+ + +V+ L P+T + + G ++T + VP + + + + S
Sbjct: 444 DMDPKAPQHVVNHLPPYTNVSLKMILTNPEGRKESEETIIQTDEDVPGPVPVKSLQGTSF 503
Query: 582 SSSILLYWDPPEYPNGKITHYTI-YAMELDTNRAFQIT----TIDNSF-----LITGLKK 631
+ I L W P PNG IT Y I Y+ + A + T+ N + + L
Sbjct: 504 ENKIFLNWKEPLDPNGIITQYEISYSSIRSFDPAVPVAGPPQTVSNLWNSTHHVFMHLHP 563
Query: 632 YTKYKMRVAASTHVGESSLSEENDIFVRTSEDEPESSPQDVEVIDVTADEIRLKWSPPEK 691
T Y+ + AST G + N ++ P+ D ++ TA I + P +
Sbjct: 564 GTTYQFFIRASTVKGFGPATAINVTTNISAPTLPDYEGVDAS-LNETATTITVLLRPAQA 622
Query: 692 PNGIIIAYEVLYKNIDTLYMKNTSTTDIILRNLRPHTLYNISVRSYTRFGHGNQ---VSS 748
I AY+++ ++ L+ T R Y + V G +
Sbjct: 623 KGAPISAYQIV---VEELHPHRTK------REAGAMECYQVPVTYQNAMSGGAPYYFAAE 673
Query: 749 LLSVRTSETVPDSAPENITYKNISSGEIELSFLPPSSPNGIIQKYTIYLKRSNGNEERT 807
L E P + +N TY+ + PP +P + Y IY + + E+ T
Sbjct: 674 LPPGNLPEPAPFTVGDNRTYQGF--------WNPPLAPR---KGYNIYFQAMSSVEKET 721
Score = 33.5 bits (75), Expect = 2.5
Identities = 41/193 (21%), Positives = 64/193 (33%), Gaps = 29/193 (15%)
Query: 1205 ILEELSPFTLYSFFAAARTRKGLGPSSILFFYTDESVPLAPPQNLTLINCTSDFVWLKWS 1264
++ L P+T S +G S TDE VP P + ++L W
Sbjct: 453 VVNHLPPYTNVSLKMILTNPEGRKESEETIIQTDEDVPGPVPVKSLQGTSFENKIFLNWK 512
Query: 1265 PSPLPGGIVKVYSFKIHEHETDTIYYKNISGFKTEAKLVG------------------LE 1306
P GI+ Y I Y +I F + G L
Sbjct: 513 EPLDPNGIITQYE----------ISYSSIRSFDPAVPVAGPPQTVSNLWNSTHHVFMHLH 562
Query: 1307 PVSTYSIRVSAFTKVGNGNQFS-NVVKFTTQESVPDVVQNMQCMATSWQSVLVKWDPPKK 1365
P +TY + A T G G + NV + ++PD + + ++ V P +
Sbjct: 563 PGTTYQFFIRASTVKGFGPATAINVTTNISAPTLPDYEGVDASLNETATTITVLLRPAQA 622
Query: 1366 ANGIITQYMVTVE 1378
I+ Y + VE
Sbjct: 623 KGAPISAYQIVVE 635
>gi|148539858 protein tyrosine phosphatase, receptor type, T isoform 1
precursor [Homo sapiens]
Length = 1460
Score = 223 bits (567), Expect = 2e-57
Identities = 118/301 (39%), Positives = 180/301 (59%), Gaps = 8/301 (2%)
Query: 1974 LSY-RKSIKP-ISKKSFLQHVEELCTNNNLKFQEEFSELPKFLQDLSSTDADLPWNRAKN 2031
+SY R +P I LQH+ ++ F+EE+ LP+ Q S A NR KN
Sbjct: 877 MSYPRDQFQPAIRVADLLQHITQMKRGQGYGFKEEYEALPEG-QTASWDTAKEDENRNKN 935
Query: 2032 RFPNIKPYNNNRVKLIADASVPGSDYINASYISGYLCPNEFIATQGPLPGTVGDFWRMVW 2091
R+ NI Y+++RV+L+ P SDYINA+YI GY P +IATQGP+ TV DFWRM+W
Sbjct: 936 RYGNIISYDHSRVRLLVLDGDPHSDYINANYIDGYHRPRHYIATQGPMQETVKDFWRMIW 995
Query: 2092 ETRAKTLVMLTQCFEKGRIRCHQYWPEDNKPVTVFGDIVITKLMEDVQIDWTIRDLKIER 2151
+ + ++VM+T E GR++C +YWP+D + V+GDI +T + + ++ IR +++
Sbjct: 996 QENSASIVMVTNLVEVGRVKCVRYWPDDTE---VYGDIKVTLIETEPLAEYVIRTFTVQK 1052
Query: 2152 HG--DCMTVRQCNFTAWPEHGVPENSAPLIHFVKLVRASRAHDTTPMIVHCSAGVGRTGV 2209
G + +R +FT+WP+HGVP + L+ FV+ V+ + P++VHCSAG GRTG
Sbjct: 1053 KGYHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQVKFLNPPEAGPIVVHCSAGAGRTGC 1112
Query: 2210 FIALDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLLSNKGSNQPI 2269
FIA+D + + VDI+ V ELR++R+ +VQ QY+F+H IL+ + P+
Sbjct: 1113 FIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAILEACLCGNTAIPV 1172
Query: 2270 C 2270
C
Sbjct: 1173 C 1173
Score = 111 bits (277), Expect = 9e-24
Identities = 83/277 (29%), Positives = 135/277 (48%), Gaps = 20/277 (7%)
Query: 1999 NNLKFQEEFSELPKFLQDLSSTDAD---LPWNRAKNRFPNIKPYNNNRVKLIADASVPG- 2054
N+ + ++EF L + D LP N KNR ++ P + LI SV G
Sbjct: 1190 NSSQIKDEFQTLNIVTPRVRPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLI---SVDGE 1246
Query: 2055 -SDYINASYISGYLCPNEFIATQGPLPGTVGDFWRMVWETRAKTLVMLTQCFEKGRIRCH 2113
S+YINA+ + + P F+ TQ PLP TV DFWR+V++ ++VML + + + C
Sbjct: 1247 SSNYINAALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNE-MDTAQF-CM 1304
Query: 2114 QYWPEDNKPVTVFGDIVITKLMEDVQIDWTIRDLKI----ERHGDCMTVRQCNFTAWPEH 2169
QYWPE K +G I + + D+ D R +I V+ + WP +
Sbjct: 1305 QYWPE--KTSGCYGPIQVEFVSADIDEDIIHRIFRICNMARPQDGYRIVQHLQYIGWPAY 1362
Query: 2170 -GVPENSAPLIHFV-KLVRASRAHDTTP--MIVHCSAGVGRTGVFIALDHLTQHINDHDF 2225
P + L+ V +L + +D +VHC G GR+G F A+ + + I +
Sbjct: 1363 RDTPPSKRSLLKVVRRLEKWQEQYDGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNI 1422
Query: 2226 VDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLLSN 2262
+D++ +V LR+ + MV+ L QY F+++ L+ LS+
Sbjct: 1423 IDVFHIVKTLRNNKSNMVETLEQYKFVYEVALEYLSS 1459
Score = 73.9 bits (180), Expect = 2e-12
Identities = 89/404 (22%), Positives = 155/404 (38%), Gaps = 55/404 (13%)
Query: 515 TTRNQYITDIAAEQLSYVIRRLVPFTEHMISVSAFTIMGEG------PPTVLSVRTRQQV 568
TT + + +Y + L P E+ I V T GEG PP + V
Sbjct: 329 TTTGTWAETHIVDSPNYKLWHLDPDVEYEIRV-LLTRPGEGGTGPPGPPLTTRTKCADPV 387
Query: 569 --PSSIKIINYKNISSSSILLYWDPPEYPNGKITHYTI-----YAMELDTNRAFQITTID 621
P +++I++ I + + L W+P Y + Y + Y A ++
Sbjct: 388 HGPQNVEIVD---IRARQLTLQWEPFGYAVTRCHSYNLTVQYQYVFNQQQYEAEEVIQTS 444
Query: 622 NSFLITGLKKYTKYKMRVAASTHVGESSLSEENDIFVRTSEDEPESSPQDVEVIDVTADE 681
+ + + GL+ + ++R+ S G E ++ V+T ED P + P + ++
Sbjct: 445 SHYTLRGLRPFMTIRLRLLLSNPEGRM---ESEELVVQTEEDVPGAVPLESIQGGPFEEK 501
Query: 682 IRLKWSPPEKPNGIIIAYEVLYKNIDTL------------YMKNTSTTDIILRNLRPHTL 729
I ++W PP + NG+I YE+ YK + +L K + T + L P T
Sbjct: 502 IYIQWKPPNETNGVITLYEINYKAVGSLDPSADLSSQRGKVFKLRNETHHLFVGLYPGTT 561
Query: 730 YNISVRSYTRFGHGNQVSSLLSVRTSETVPDSAPE--NITYKNISSGEIELSFLPPSSPN 787
Y+ ++++ T G G V++ ++ + S S PE T N + I + P S
Sbjct: 562 YSFTIKASTAKGFGPPVTTRIATKIS---APSMPEYDTDTPLNETDTTITVMLKPAQSRG 618
Query: 788 GIIQKYTIYLKRSNGNEERTINTTSLTQNIKVLKKYTQYIIEVSASTLKGEGVRSAPISI 847
+ Y + +K EER + I+ Y S +L P ++
Sbjct: 619 APVSVYQLVVK-----EERLQKSRRAADIIECFSVPVSYRNASSLDSLHYFAAELKPANL 673
Query: 848 LTEEDAPDSPPQDFSVKQLSGVTVKLSWQPPLEPNGIILYYTVY 891
Q F+V T W PPL P + Y++Y
Sbjct: 674 --------PVTQPFTVG--DNKTYNGYWNPPLSP---LKSYSIY 704
Score = 65.1 bits (157), Expect = 8e-10
Identities = 91/382 (23%), Positives = 147/382 (38%), Gaps = 44/382 (11%)
Query: 1429 VPSVPTNIAFSDVQSTSATLTWIRPDT--------ILGYFQNYKITTQLRAQKCKEWESE 1480
V PT IA ++ + AT WI+P+ I+ Y+ TT W
Sbjct: 285 VKEPPTPIAPPELLAVGATYLWIKPNANSIIGDGPIILKEVEYRTTTGT-------WAET 337
Query: 1481 ECVEYQKIQYLYEAHLTEETVYGLKKFRWYRFQVAASTNAGYGNASNWISTKTLPGPPDG 1540
V+ + HL + Y + R + G G ++T+T P
Sbjct: 338 HIVDSPNYKLW---HLDPDVEYEI------RVLLTRPGEGGTGPPGPPLTTRTKCADPVH 388
Query: 1541 PPENVHVVATSPFSISISWSEPAVITGPTCYLIDVKSVDNDEFNISFIKSNEENKTIEIK 1600
P+NV +V +++ W EP C+ ++ FN ++ E +T
Sbjct: 389 GPQNVEIVDIRARQLTLQW-EPFGYAVTRCHSYNLTVQYQYVFNQQQYEAEEVIQTSSHY 447
Query: 1601 DLEIFTRYSVVITAFTGNISAAYVEGK-SSAEMIVTTLESAPKDPPNNMTFQKIPDEVTK 1659
L + + + + EG+ S E++V T E P P + Q P E K
Sbjct: 448 TLRGLRPFMTIRL----RLLLSNPEGRMESEELVVQTEEDVPGAVPLE-SIQGGPFE-EK 501
Query: 1660 FQLTFLPPSQPNGNIQVYQALVYRED---DPTAVQIHNLSIIQKTNTFVIAMLEGLKGGH 1716
+ + PP++ NG I +Y+ + Y+ DP+A + K + GL G
Sbjct: 502 IYIQWKPPNETNGVITLYE-INYKAVGSLDPSADLSSQRGKVFKLRNETHHLFVGLYPGT 560
Query: 1717 TYNISVYAVNSAGAGPKVPMRITMDIKAPARPKTKPTPIYDATGKLLVTSTTITIRMPIC 1776
TY+ ++ A + G GP V RI I AP+ P+ YD L T TTIT+ +
Sbjct: 561 TYSFTIKASTAKGFGPPVTTRIATKISAPSMPE------YDTDTPLNETDTTITVMLKPA 614
Query: 1777 YYSDDHGPIKNVQVLVTETGAQ 1798
P+ Q++V E Q
Sbjct: 615 --QSRGAPVSVYQLVVKEERLQ 634
Score = 61.2 bits (147), Expect = 1e-08
Identities = 75/309 (24%), Positives = 128/309 (41%), Gaps = 41/309 (13%)
Query: 1175 VKPN-------GAIISYDL---TLQGPNENYSFITSDNYIILEELSPFTLYSFFAAARTR 1224
+KPN G II ++ T G + S NY L L P Y TR
Sbjct: 307 IKPNANSIIGDGPIILKEVEYRTTTGTWAETHIVDSPNYK-LWHLDPDVEYEI-RVLLTR 364
Query: 1225 KGLG----PSSILFFYTDESVPLAPPQNLTLINCTSDFVWLKWSPSPLPGGIVKVYSFKI 1280
G G P L T + P+ PQN+ +++ + + L+W P + + +S+ +
Sbjct: 365 PGEGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQWEPFGY--AVTRCHSYNL 422
Query: 1281 ---HEHETDTIYYKNISGFKTEAK--LVGLEPVSTYSIRVSAFTKVGNGNQFSNVVKFTT 1335
+++ + Y+ +T + L GL P T +R+ G VV+ T
Sbjct: 423 TVQYQYVFNQQQYEAEEVIQTSSHYTLRGLRPFMTIRLRLLLSNPEGRMESEELVVQ--T 480
Query: 1336 QESVPDVVQNMQCMATSWQS-VLVKWDPPKKANGIITQYMVTVER-----NSTKVSPQ-- 1387
+E VP V ++ + ++W PP + NG+IT Y + + S +S Q
Sbjct: 481 EEDVPGAVPLESIQGGPFEEKIYIQWKPPNETNGVITLYEINYKAVGSLDPSADLSSQRG 540
Query: 1388 -------DHMYTFIKLLANTSYVFKVRASTSAGEGDESTCHVSTLPETVPSVPTNIAFSD 1440
+ + F+ L T+Y F ++AST+ G G T ++T + PS+P +
Sbjct: 541 KVFKLRNETHHLFVGLYPGTTYSFTIKASTAKGFGPPVTTRIAT-KISAPSMPEYDTDTP 599
Query: 1441 VQSTSATLT 1449
+ T T+T
Sbjct: 600 LNETDTTIT 608
Score = 57.0 bits (136), Expect = 2e-07
Identities = 42/156 (26%), Positives = 66/156 (42%), Gaps = 13/156 (8%)
Query: 1140 QLYIKTEEDVPETSPIINTFKNLSSTSVLLSWDPPVKPNGAIISYDLTLQG-----PNEN 1194
+L ++TEEDVP P+ + + + W PP + NG I Y++ + P+ +
Sbjct: 475 ELVVQTEEDVPGAVPLESIQGGPFEEKIYIQWKPPNETNGVITLYEINYKAVGSLDPSAD 534
Query: 1195 YSF-------ITSDNYIILEELSPFTLYSFFAAARTRKGLGPSSILFFYTDESVPLAPPQ 1247
S + ++ + + L P T YSF A T KG GP T S P P
Sbjct: 535 LSSQRGKVFKLRNETHHLFVGLYPGTTYSFTIKASTAKGFGPPVTTRIATKISAPSMPEY 594
Query: 1248 NL-TLINCTSDFVWLKWSPSPLPGGIVKVYSFKIHE 1282
+ T +N T + + P+ G V VY + E
Sbjct: 595 DTDTPLNETDTTITVMLKPAQSRGAPVSVYQLVVKE 630
Score = 48.1 bits (113), Expect = 1e-04
Identities = 80/370 (21%), Positives = 143/370 (38%), Gaps = 31/370 (8%)
Query: 837 GEGVRSAPISILTEEDAPDSPPQDFSVKQLSGVTVKLSWQPPLEPNGIILYYTVYVWNRS 896
G GV + I+ E P +PP+ +V + + +K + + IIL Y
Sbjct: 274 GSGVSNYAELIVKEPPTPIAPPELLAVGA-TYLWIKPNANSIIGDGPIILKEVEYRTTTG 332
Query: 897 SLKTINVTET-SLELSDLDYNVEYSAYVTASTRFGDGKTR--SNIISFQTPEGAPSDPPK 953
+ ++ ++ + +L LD +VEY V TR G+G T ++ +T P P+
Sbjct: 333 TWAETHIVDSPNYKLWHLDPDVEYEIRVLL-TRPGEGGTGPPGPPLTTRTKCADPVHGPQ 391
Query: 954 DVYYANLSSSSIILFWTPPSKPNGIIQYYSVYYRNTSGTFMQNFTLHEVTNDFDNMTVST 1013
+V ++ + + L W P Y++ + Q + EV + T+
Sbjct: 392 NVEIVDIRARQLTLQWEPFGYAVTRCHSYNLTVQYQYVFNQQQYEAEEVIQTSSHYTLRG 451
Query: 1014 IIDKLTIFSYYTFWLTASTSVGNGNKSSDIIEVYTDQDIPEGFVGNLTYESISS----TA 1069
+ +TI L S G S+ + V T++D+P G + ESI
Sbjct: 452 LRPFMTIR------LRLLLSNPEGRMESEELVVQTEEDVP----GAVPLESIQGGPFEEK 501
Query: 1070 INVSWVPPAQPNGLVFYY---------VSLILQQTPRHVRPPLVTYERSIYFDNLEKYTD 1120
I + W PP + NG++ Y + + + + + E F L T
Sbjct: 502 IYIQWKPPNETNGVITLYEINYKAVGSLDPSADLSSQRGKVFKLRNETHHLFVGLYPGTT 561
Query: 1121 YILKITPSTEKGFSDTYTAQLYIK-TEEDVPETSPIINTFKNLSSTSVLLSWDPPVKPNG 1179
Y I ST KGF T ++ K + +PE +T N + T++ + P
Sbjct: 562 YSFTIKASTAKGFGPPVTTRIATKISAPSMPEYD--TDTPLNETDTTITVMLKPAQSRGA 619
Query: 1180 AIISYDLTLQ 1189
+ Y L ++
Sbjct: 620 PVSVYQLVVK 629
Score = 46.6 bits (109), Expect = 3e-04
Identities = 51/191 (26%), Positives = 74/191 (38%), Gaps = 26/191 (13%)
Query: 255 QNEISSVWKEPISFVVTHLRPYTTYLFEVSAATTEAGYIDST--IVRTPESVPEGPPQNC 312
Q E V + + + LRP+ T + + E G ++S +V+T E VP P
Sbjct: 434 QYEAEEVIQTSSHYTLRGLRPFMTIRLRLLLSNPE-GRMESEELVVQTEEDVPGAVPLES 492
Query: 313 VTGNITGKSFSILWDPPTIVTG-----KFSYR--------VELYGPSGRI--LDNSTKDL 357
+ G + I W PP G + +Y+ +L G++ L N T L
Sbjct: 493 IQGGPFEEKIYIQWKPPNETNGVITLYEINYKAVGSLDPSADLSSQRGKVFKLRNETHHL 552
Query: 358 KFAFTNLTPFTMYDVYIAAETSAGTGPKSNISVFT---PPDVPGAVFDLQLAEVESTQVR 414
F L P T Y I A T+ G GP + T P +P D L E ++T
Sbjct: 553 ---FVGLYPGTTYSFTIKASTAKGFGPPVTTRIATKISAPSMPEYDTDTPLNETDTTIT- 608
Query: 415 ITWKKPRQPNG 425
KP Q G
Sbjct: 609 -VMLKPAQSRG 618
Score = 38.5 bits (88), Expect = 0.077
Identities = 36/146 (24%), Positives = 58/146 (39%), Gaps = 16/146 (10%)
Query: 299 RTPESVPEGPPQNCVTGNITGKSFSILWDP-PTIVTGKFSYRVELYGP---------SGR 348
RT + P PQN +I + ++ W+P VT SY + + +
Sbjct: 380 RTKCADPVHGPQNVEIVDIRARQLTLQWEPFGYAVTRCHSYNLTVQYQYVFNQQQYEAEE 439
Query: 349 ILDNSTKDLKFAFTNLTPFTMYDVYIAAETSAGTGPKSNISVFTPPDVPGAV--FDLQLA 406
++ S+ + L PF + + G + V T DVPGAV +Q
Sbjct: 440 VIQTSSH---YTLRGLRPFMTIRLRLLLSNPEGRMESEELVVQTEEDVPGAVPLESIQGG 496
Query: 407 EVESTQVRITWKKPRQPNGIINQYRV 432
E ++ I WK P + NG+I Y +
Sbjct: 497 PFEE-KIYIQWKPPNETNGVITLYEI 521
Score = 33.5 bits (75), Expect = 2.5
Identities = 60/252 (23%), Positives = 89/252 (35%), Gaps = 34/252 (13%)
Query: 72 ILLSWNTPPNPNGRIISYIVKYKEVCPW-----MQTVYTQVRSKPDSLEVLLTNLNPGTT 126
I + W P NG I Y + YK V + + +V + L L PGTT
Sbjct: 502 IYIQWKPPNETNGVITLYEINYKAVGSLDPSADLSSQRGKVFKLRNETHHLFVGLYPGTT 561
Query: 127 YEIKVAAENSAGIGVFSDPFLFQTAE--SAPGKVVNLTVEAYNASAVKL-IWYLPRQPNG 183
Y + A + G F P + A SAP T N + + + P Q G
Sbjct: 562 YSFTIKASTAKG---FGPPVTTRIATKISAPSMPEYDTDTPLNETDTTITVMLKPAQSRG 618
Query: 184 -KITSFKISVKHARSGIVVKDVSIRVEDIL-TGKLPECNENS---ESFLWSTASPSPTLG 238
++ +++ VK R S R DI+ +P N+ +S + A P
Sbjct: 619 APVSVYQLVVKEER-----LQKSRRAADIIECFSVPVSYRNASSLDSLHYFAAELKPANL 673
Query: 239 RVTPPSRTTHSSSTLTQNEISSVWKEPISFVVTHLRPYTTYLFEVSAATTEAGYIDSTIV 298
VT P + + + W P+S L+ Y+ Y +S A G V
Sbjct: 674 PVTQPFTVGDNKT------YNGYWNPPLS----PLKSYSIYFQALSKAN---GETKINCV 720
Query: 299 RTPESVPEGPPQ 310
R P G Q
Sbjct: 721 RLATKAPMGSAQ 732
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.133 0.392
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 91,751,486
Number of Sequences: 37866
Number of extensions: 4320556
Number of successful extensions: 22421
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 190
Number of HSP's successfully gapped in prelim test: 95
Number of HSP's that attempted gapping in prelim test: 10574
Number of HSP's gapped (non-prelim): 5049
length of query: 2299
length of database: 18,247,518
effective HSP length: 118
effective length of query: 2181
effective length of database: 13,779,330
effective search space: 30052718730
effective search space used: 30052718730
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 70 (31.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.