Search of human proteins with 22218341

Search of human proteins with 22218341

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|22218341 matrix metalloproteinase 21 preproprotein [Homo
sapiens]
         (569 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|22218341 matrix metalloproteinase 21 preproprotein [Homo sapi...  1204   0.0  
gi|112382270 matrix metalloproteinase 17 preproprotein [Homo sap...   170   3e-42
gi|4505213 matrix metalloproteinase 19 isoform rasi-1 preproprot...   158   1e-38
gi|4826834 matrix metalloproteinase 14 preproprotein [Homo sapiens]   147   2e-35
gi|4505217 matrix metalloproteinase 3 preproprotein [Homo sapiens]    147   2e-35
gi|4505205 matrix metalloproteinase 10 preproprotein [Homo sapiens]   147   2e-35
gi|5729929 matrix metalloproteinase 24 preproprotein [Homo sapiens]   146   4e-35
gi|73858572 matrix metalloproteinase 12 preproprotein [Homo sapi...   142   6e-34
gi|13236530 matrix metalloproteinase 28 isoform 1 preproprotein ...   138   2e-32
gi|11968059 matrix metalloproteinase 25 preproprotein [Homo sapi...   135   8e-32
gi|4505221 matrix metalloproteinase 8 preproprotein [Homo sapiens]    130   4e-30
gi|13027802 matrix metalloproteinase 16 isoform 1 preproprotein ...   130   4e-30
gi|58331148 matrix metalloproteinase 11 preproprotein [Homo sapi...   129   7e-30
gi|4505215 matrix metalloproteinase 1 isoform 1 preproprotein [H...   128   2e-29
gi|45359865 matrix metalloproteinase 20 preproprotein [Homo sapi...   127   4e-29
gi|4505209 matrix metalloproteinase 13 preproprotein [Homo sapiens]   126   5e-29
gi|225543094 matrix metalloproteinase 1 isoform 2 [Homo sapiens]      124   2e-28
gi|73808268 matrix metalloproteinase 27 [Homo sapiens]                124   2e-28
gi|4505219 matrix metalloproteinase 7 preproprotein [Homo sapiens]    108   1e-23
gi|4505211 matrix metalloproteinase 15 preproprotein [Homo sapiens]   107   3e-23
gi|149999365 matrix metalloproteinase 16 isoform 2 preproprotein...   102   9e-22
gi|189217853 matrix metalloproteinase 2 isoform b [Homo sapiens]       95   2e-19
gi|11342666 matrix metalloproteinase 2 isoform a preproprotein [...    95   2e-19
gi|73808266 matrix metalloproteinase 26 preproprotein [Homo sapi...    89   1e-17
gi|5902004 matrix metalloproteinase 23B precursor [Homo sapiens]       81   3e-15
gi|74272287 matrix metalloproteinase 9 preproprotein [Homo sapiens]    69   1e-11
gi|239750339 PREDICTED: hypothetical protein XP_002347374 [Homo ...    64   3e-10
gi|73808271 matrix metalloproteinase 28 isoform 3 [Homo sapiens]       55   2e-07
gi|88853069 vitronectin precursor [Homo sapiens]                       49   2e-05
gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapi...    44   4e-04

>gi|22218341 matrix metalloproteinase 21 preproprotein [Homo
           sapiens]
          Length = 569

 Score = 1204 bits (3116), Expect = 0.0
 Identities = 569/569 (100%), Positives = 569/569 (100%)

Query: 1   MLAASIFRPTLLLCWLAAPWPTQPESLFHSRDRSDLEPSPLRQAKPIADLHAAQRFLSRY 60
           MLAASIFRPTLLLCWLAAPWPTQPESLFHSRDRSDLEPSPLRQAKPIADLHAAQRFLSRY
Sbjct: 1   MLAASIFRPTLLLCWLAAPWPTQPESLFHSRDRSDLEPSPLRQAKPIADLHAAQRFLSRY 60

Query: 61  GWSGVWAAWGPSPEGPPETPKGAALAEAVRRFQRANALPASGELDAATLAAMNRPRCGVP 120
           GWSGVWAAWGPSPEGPPETPKGAALAEAVRRFQRANALPASGELDAATLAAMNRPRCGVP
Sbjct: 61  GWSGVWAAWGPSPEGPPETPKGAALAEAVRRFQRANALPASGELDAATLAAMNRPRCGVP 120

Query: 121 DMRPPPPSAPPSPPGPPPRARSRRSPRAPLSLSRRGWQPRGYPDGGAAQAFSKRTLSWRL 180
           DMRPPPPSAPPSPPGPPPRARSRRSPRAPLSLSRRGWQPRGYPDGGAAQAFSKRTLSWRL
Sbjct: 121 DMRPPPPSAPPSPPGPPPRARSRRSPRAPLSLSRRGWQPRGYPDGGAAQAFSKRTLSWRL 180

Query: 181 LGEALSSQLSVADQRRIVALAFRMWSEVTPLDFREDLAAPGAAVDIKLGFGRGRHLGCPR 240
           LGEALSSQLSVADQRRIVALAFRMWSEVTPLDFREDLAAPGAAVDIKLGFGRGRHLGCPR
Sbjct: 181 LGEALSSQLSVADQRRIVALAFRMWSEVTPLDFREDLAAPGAAVDIKLGFGRGRHLGCPR 240

Query: 241 AFDGSGQEFAHAWRLGDIHFDDDEHFTPPTSDTGISLLKVAVHEIGHVLGLPHTYRTGSI 300
           AFDGSGQEFAHAWRLGDIHFDDDEHFTPPTSDTGISLLKVAVHEIGHVLGLPHTYRTGSI
Sbjct: 241 AFDGSGQEFAHAWRLGDIHFDDDEHFTPPTSDTGISLLKVAVHEIGHVLGLPHTYRTGSI 300

Query: 301 MQPNYIPQEPAFELDWSDRKAIQKLYGSCEGSFDTAFDWIRKERNQYGEVMVRFSTYFFR 360
           MQPNYIPQEPAFELDWSDRKAIQKLYGSCEGSFDTAFDWIRKERNQYGEVMVRFSTYFFR
Sbjct: 301 MQPNYIPQEPAFELDWSDRKAIQKLYGSCEGSFDTAFDWIRKERNQYGEVMVRFSTYFFR 360

Query: 361 NSWYWLYENRNNRTRYGDPIQILTGWPGIPTHNIDAFVHIWTWKRDERYFFQGNQYWRYD 420
           NSWYWLYENRNNRTRYGDPIQILTGWPGIPTHNIDAFVHIWTWKRDERYFFQGNQYWRYD
Sbjct: 361 NSWYWLYENRNNRTRYGDPIQILTGWPGIPTHNIDAFVHIWTWKRDERYFFQGNQYWRYD 420

Query: 421 SDKDQALTEDEQGKSYPKLISEGFPGIPSPLDTAFYDRRQKLIYFFKESLVFAFDVNRNR 480
           SDKDQALTEDEQGKSYPKLISEGFPGIPSPLDTAFYDRRQKLIYFFKESLVFAFDVNRNR
Sbjct: 421 SDKDQALTEDEQGKSYPKLISEGFPGIPSPLDTAFYDRRQKLIYFFKESLVFAFDVNRNR 480

Query: 481 VLNSYPKRITEVFPAVIPQNHPFRNIDSAYYSYAYNSIFFFKGNAYWKVVNDKDKQQNSW 540
           VLNSYPKRITEVFPAVIPQNHPFRNIDSAYYSYAYNSIFFFKGNAYWKVVNDKDKQQNSW
Sbjct: 481 VLNSYPKRITEVFPAVIPQNHPFRNIDSAYYSYAYNSIFFFKGNAYWKVVNDKDKQQNSW 540

Query: 541 LPANGLFPKKFISEKWFDVCDVHISTLNM 569
           LPANGLFPKKFISEKWFDVCDVHISTLNM
Sbjct: 541 LPANGLFPKKFISEKWFDVCDVHISTLNM 569


>gi|112382270 matrix metalloproteinase 17 preproprotein [Homo
           sapiens]
          Length = 603

 Score =  170 bits (431), Expect = 3e-42
 Identities = 150/531 (28%), Positives = 233/531 (43%), Gaps = 104/531 (19%)

Query: 38  PSPLRQAKPIADLHAAQRFLSRYGWSGVWAAWGPSPEGPPETPKGAALAEAVRRFQRANA 97
           P+P  +A+   DL     +LSR+G+        P+     +      L++A+   Q+   
Sbjct: 40  PAPAPRAE---DLSLGVEWLSRFGYLP------PADPTTGQLQTQEELSKAITAMQQFGG 90

Query: 98  LPASGELDAATLAAMNRPRCGVPDMRPPPPSAPPSPPGPPPRARSRRSPRAPLSLSRRGW 157
           L A+G LD ATLA M  PRC +PD+              P   ++RR  +AP        
Sbjct: 91  LEATGILDEATLALMKTPRCSLPDL--------------PVLTQARRRRQAP-------- 128

Query: 158 QPRGYPDGGAAQAFSKRTLSWRLLGEALSSQLSVADQRRIVALAFRMWSEVTPLDFREDL 217
                    A   ++KR LSWR+      S L     R ++  A ++WS++ PL+F E  
Sbjct: 129 ---------APTKWNKRNLSWRVRTFPRDSPLGHDTVRALMYYALKVWSDIAPLNFHE-- 177

Query: 218 AAPGAAVDIKLGFGRGRHL-GCPRAFDGSGQEFAHAW------RLGDIHFDDDEHFTPPT 270
              G+A DI++ F +  H  G P  FDG G   AHA+        GD HFDDDE +T  +
Sbjct: 178 -VAGSAADIQIDFSKADHNDGYP--FDGPGGTVAHAFFPGHHHTAGDTHFDDDEAWTFRS 234

Query: 271 SDT-GISLLKVAVHEIGHVLGLPHTYRTGSIMQPNY---IPQEPAFELDWSDRKAIQKLY 326
           SD  G+ L  VAVHE GH +GL H     SIM+P Y   +     + L + D+  + +LY
Sbjct: 235 SDAHGMDLFAVAVHEFGHAIGLSHVAAAHSIMRPYYQGPVGDPLRYGLPYEDKVRVWQLY 294

Query: 327 GSCEGSFDTA---------------------FDWIRKERNQYGEV-MVRFSTYFFRNSWY 364
           G  E    TA                      D   +    +  V  +R   +FF+  ++
Sbjct: 295 GVRESVSPTAQPEEPPLLPEPPDNRSSAPPRKDVPHRCSTHFDAVAQIRGEAFFFKGKYF 354

Query: 365 WLYENRNNRTRYGDPIQILTGWPGIPTHNIDAFVHIWTWKRDER-YFFQGNQYWRYDSDK 423
           W    R+       P Q+   W G+P H +D+   ++    D +  FF+G++YW +   K
Sbjct: 355 WRL-TRDRHLVSLQPAQMHRFWRGLPLH-LDSVDAVYERTSDHKIVFFKGDRYWVF---K 409

Query: 424 DQALTEDEQGKSYPKLISEGFPGIPSPLDTAFYDRRQKLIYFFKESLVFAFDVNRNRVLN 483
           D  + E      YP+ +S+ F   P  +D AF        YFFK+ L + +D +   +  
Sbjct: 410 DNNVEE-----GYPRPVSD-FSLPPGGIDAAFSWAHNDRTYFFKDQLYWRYDDHTRHMDP 463

Query: 484 SYPKRITEVFPAVIPQNHPFRNIDSAY---YSYAYNSIFFFKGNAYWKVVN 531
            YP            Q+  +R + S       ++  + +FF+G  YWKV++
Sbjct: 464 GYP-----------AQSPLWRGVPSTLDDAMRWSDGASYFFRGQEYWKVLD 503


>gi|4505213 matrix metalloproteinase 19 isoform rasi-1 preproprotein
           [Homo sapiens]
          Length = 508

 Score =  158 bits (400), Expect = 1e-38
 Identities = 148/502 (29%), Positives = 215/502 (42%), Gaps = 109/502 (21%)

Query: 56  FLSRYGWSGVWAAWGPSPEGPPETPKGAALAEAVRRFQRANALPASGELDAATLAAMNRP 115
           +LS+YG+          P       K   + EA+R FQ A+ LP SG+LD AT A M +P
Sbjct: 31  YLSQYGYL-------QKPLEGSNNFKPEDITEALRAFQEASELPVSGQLDDATRARMRQP 83

Query: 116 RCGVPDMRPPPPSAPPSPPGPPPRARSRRSPRAPLSLSRRGWQPRGYPDGGAAQAFSKRT 175
           RCG+ D               P   ++ +     L L R  W+              K+ 
Sbjct: 84  RCGLED---------------PFNQKTLKY----LLLGR--WR--------------KKH 108

Query: 176 LSWRLLGEALSSQLSVADQRRIVALAFRMWSEVTPLDFREDLAAPGAAVDIKLGFGRGRH 235
           L++R+L   L S L     R  +  AF+ WS V PL F+E  A    A DI+L F   + 
Sbjct: 109 LTFRILN--LPSTLPPHTARAALRQAFQDWSNVAPLTFQEVQAG---AADIRLSFHGRQS 163

Query: 236 LGCPRAFDGSGQEFAHAW--RLGDIHFDDDEHFTPPTSDTGISLLKVAVHEIGHVLGLPH 293
             C   FDG G+  AHA    LG +HFD+DE +T  T   G++L  +A HE+GH LGL H
Sbjct: 164 SYCSNTFDGPGRVLAHADIPELGSVHFDEDEFWTEGTY-RGVNLRIIAAHEVGHALGLGH 222

Query: 294 TYRTGSIMQPNYIPQEPAFELDWSDRKAIQKLYGSCEGSFDTAFDWIRKERNQYGEVMV- 352
           +  + ++M P Y    P F+L   D   IQ LYG            IR E  +  E+   
Sbjct: 223 SRYSQALMAPVYEGYRPHFKLHPDDVAGIQALYGK-------KSPVIRDEEEEETELPTV 275

Query: 353 -------------------------RFSTYFFRNSWYWLYENRNNRTRYGDPIQILTGWP 387
                                    R  TY F+  + W   +       G   ++   W 
Sbjct: 276 PPVPTEPSPMPDPCSSELDAMMLGPRGKTYAFKGDYVWTVSDSGP----GPLFRVSALWE 331

Query: 388 GIPTHNIDAFVHIWTWKRDERYFFQGNQYWRYDSDKDQALTEDEQGKSYPKLISEGFPGI 447
           G+P  N+DA V  ++ +    +FF+G++ WRY + K            +PK ++   P  
Sbjct: 332 GLP-GNLDAAV--YSPRTQWIHFFKGDKVWRYINFK--------MSPGFPKKLNRVEPN- 379

Query: 448 PSPLDTAFYDRRQKLIYFFKESLVFAFDVNRNRVLNSYPKRITEVFPAVIPQNHPFRNID 507
              LD A Y    + ++ FK S  + +D       +SYPK I  +F  V   N P     
Sbjct: 380 ---LDAALYWPLNQKVFLFKGSGYWQWDELARTDFSSYPKPIKGLFTGV--PNQP----- 429

Query: 508 SAYYSYAYNSIFFFKGNAYWKV 529
           SA  S+    ++FFKG  YW++
Sbjct: 430 SAAMSWQDGRVYFFKGKVYWRL 451



 Score = 30.8 bits (68), Expect = 3.5
 Identities = 13/29 (44%), Positives = 18/29 (62%)

Query: 505 NIDSAYYSYAYNSIFFFKGNAYWKVVNDK 533
           N+D+A YS     I FFKG+  W+ +N K
Sbjct: 336 NLDAAVYSPRTQWIHFFKGDKVWRYINFK 364


>gi|4826834 matrix metalloproteinase 14 preproprotein [Homo sapiens]
          Length = 582

 Score =  147 bits (372), Expect = 2e-35
 Identities = 147/504 (29%), Positives = 210/504 (41%), Gaps = 123/504 (24%)

Query: 84  ALAEAVRRFQRANALPASGELDAATLAAMNRPRCGVPDMRPPPPSAPPSPPGPPPRARSR 143
           +L+ A+   Q+   L  +G+ DA T+ AM RPRCGVPD             G   +A  R
Sbjct: 60  SLSAAIAAMQKFYGLQVTGKADADTMKAMRRPRCGVPDKF-----------GAEIKANVR 108

Query: 144 RSPRAPLSLSRRGWQPRGYPDGGAAQAFSKRTLSWRLLGEALSSQLSVADQRRIVALAFR 203
           R   A   L    WQ          Q ++ +      +GE  + +         +  AFR
Sbjct: 109 RKRYAIQGLK---WQHNEITF--CIQNYTPK------VGEYATYEA--------IRKAFR 149

Query: 204 MWSEVTPLDFREDLAAPGAAV--------DIKLGFGRGRHLGCPRAFDGSGQEFAHAWRL 255
           +W   TPL FRE    P A +        DI + F  G H G    FDG G   AHA+  
Sbjct: 150 VWESATPLRFRE---VPYAYIREGHEKQADIMIFFAEGFH-GDSTPFDGEGGFLAHAYFP 205

Query: 256 G-----DIHFDDDEHFTPPTSD-TGISLLKVAVHEIGHVLGLPHTYRTGSIMQPNYIPQE 309
           G     D HFD  E +T    D  G  +  VAVHE+GH LGL H+    +IM P Y   +
Sbjct: 206 GPNIGGDTHFDSAEPWTVRNEDLNGNDIFLVAVHELGHALGLEHSSDPSAIMAPFYQWMD 265

Query: 310 PA-FELDWSDRKAIQKLYGS---------------------------------CEGSFDT 335
              F L   DR+ IQ+LYG                                  C+G+FDT
Sbjct: 266 TENFVLPDDDRRGIQQLYGGESGFPTKMPPQPRTTSRPSVPDKPKNPTYGPNICDGNFDT 325

Query: 336 AFDWIRKERNQYGEVMVRFSTYFFRNSWYWLYENRNNRTRYGDPIQILTGWPGIPTHNID 395
                          M+R   + F+  W+W    RNN+   G P+ I   W G+P     
Sbjct: 326 V-------------AMLRGEMFVFKERWFW--RVRNNQVMDGYPMPIGQFWRGLP----- 365

Query: 396 AFVHIWTWKRDERY-FFQGNQYWRYDSDKDQALTEDEQGKSYPKLISEGFPGIPS-PLDT 453
           A ++    ++D ++ FF+G+++W +D        E      YPK I E   G+P+  +D 
Sbjct: 366 ASINTAYERKDGKFVFFKGDKHWVFD--------EASLEPGYPKHIKELGRGLPTDKIDA 417

Query: 454 AFYDRRQKLIYFFKESLVFAFDVNRNRVLNSYPKRITEVFPAVIPQN--HPFRNIDSAYY 511
           A +       YFF+ +  + F+     V + YPK I +V+   IP++    F   D  + 
Sbjct: 418 ALFWMPNGKTYFFRGNKYYRFNEELRAVDSEYPKNI-KVWEG-IPESPRGSFMGSDEVF- 474

Query: 512 SYAYNSIFFFKGNAYWKVVNDKDK 535
                  +F+KGN YWK  N K K
Sbjct: 475 ------TYFYKGNKYWKFNNQKLK 492



 Score = 40.8 bits (94), Expect = 0.003
 Identities = 29/96 (30%), Positives = 47/96 (48%), Gaps = 14/96 (14%)

Query: 356 TYFFRNSWYWLY--ENRNNRTRYGDPIQILTGWPGIPTHNIDAFVHIWTWKRDERYFFQG 413
           TYFFR + Y+ +  E R   + Y   I++  G P  P  +      ++T      YF++G
Sbjct: 427 TYFFRGNKYYRFNEELRAVDSEYPKNIKVWEGIPESPRGSFMGSDEVFT------YFYKG 480

Query: 414 NQYWRYDSDKDQALTEDEQGKSYPKLISEGFPGIPS 449
           N+YW++++ K     + E G  YPK     + G PS
Sbjct: 481 NKYWKFNNQK----LKVEPG--YPKSALRDWMGCPS 510


>gi|4505217 matrix metalloproteinase 3 preproprotein [Homo sapiens]
          Length = 477

 Score =  147 bits (372), Expect = 2e-35
 Identities = 139/493 (28%), Positives = 209/493 (42%), Gaps = 113/493 (22%)

Query: 85  LAEAVRRFQRANALPASGELDAATLAAMNRPRCGVPDMRPPPPSAPPSPPGPPPRARSRR 144
           + + +R  Q+   L  +G+LD+ TL  M +PRCGVPD+                    R 
Sbjct: 60  VVKKIREMQKFLGLEVTGKLDSDTLEVMRKPRCGVPDV-----------------GHFRT 102

Query: 145 SPRAPLSLSRRGWQPRGYPDGGAAQAFSKRTLSWRLLGEALSSQLSVADQRRIVALAFRM 204
            P  P       W+              K  L++R++           D    V  A ++
Sbjct: 103 FPGIPK------WR--------------KTHLTYRIVNYTPDLPKDAVDSA--VEKALKV 140

Query: 205 WSEVTPLDFREDLAAPGAAVDIKLGFGRGRHLGCPRAFDGSGQEFAHAWRLG-----DIH 259
           W EVTPL F       G A DI + F    H G    FDG G   AHA+  G     D H
Sbjct: 141 WEEVTPLTFSR--LYEGEA-DIMISFAVREH-GDFYPFDGPGNVLAHAYAPGPGINGDAH 196

Query: 260 FDDDEHFTPPTSDTGISLLKVAVHEIGHVLGLPHTYRTGSIMQPNY--IPQEPAFELDWS 317
           FDDDE +T  T  TG +L  VA HEIGH LGL H+  T ++M P Y  +     F L   
Sbjct: 197 FDDDEQWTKDT--TGTNLFLVAAHEIGHSLGLFHSANTEALMYPLYHSLTDLTRFRLSQD 254

Query: 318 DRKAIQKLYGSCEGSFDT----------------------AFDWIRKERNQYGEVMVRFS 355
           D   IQ LYG    S +T                      +FD +   R   GE+++   
Sbjct: 255 DINGIQSLYGPPPDSPETPLVPTEPVPPEPGTPANCDPALSFDAVSTLR---GEILI--- 308

Query: 356 TYFFRNSWYWLYENRNNRTRYGDPIQILTG-WPGIPTHNIDAFVHIWTWKRDERYFFQGN 414
              F++  +W    R +  +    + +++  WP +P+  +DA   + +  +D  + F+GN
Sbjct: 309 ---FKDRHFW----RKSLRKLEPELHLISSFWPSLPS-GVDAAYEVTS--KDLVFIFKGN 358

Query: 415 QYWRYDSDKDQALTEDEQGKSYPKLISE-GFPGIPSPLDTAFYDRRQKLIYFFKESLVFA 473
           Q+W        A+  +E    YP+ I   GFP     +D A  D+ +   YFF E   + 
Sbjct: 359 QFW--------AIRGNEVRAGYPRGIHTLGFPPTVRKIDAAISDKEKNKTYFFVEDKYWR 410

Query: 474 FDVNRNRVLNSYPKRITEVFPAVIPQNHPFRNIDSAYYSYAYNSIFFFKGNAYWKVVNDK 533
           FD  RN +   +PK+I E FP +  +      ID+ +  + +   +FF G++  +   + 
Sbjct: 411 FDEKRNSMEPGFPKQIAEDFPGIDSK------IDAVFEEFGF--FYFFTGSSQLEFDPNA 462

Query: 534 DK-----QQNSWL 541
            K     + NSWL
Sbjct: 463 KKVTHTLKSNSWL 475


>gi|4505205 matrix metalloproteinase 10 preproprotein [Homo sapiens]
          Length = 476

 Score =  147 bits (372), Expect = 2e-35
 Identities = 139/487 (28%), Positives = 203/487 (41%), Gaps = 101/487 (20%)

Query: 85  LAEAVRRFQRANALPASGELDAATLAAMNRPRCGVPDMRPPPPSAPPSPPGPPPRARSRR 144
           + + ++  Q+   L  +G+LD  TL  M +PRCGVPD+         S PG P       
Sbjct: 59  IVKKIQGMQKFLGLEVTGKLDTDTLEVMRKPRCGVPDV-----GHFSSFPGMPK------ 107

Query: 145 SPRAPLSLSRRGWQPRGYPDGGAAQAFSKRTLSWRLLGEALSSQLSVADQRRIVALAFRM 204
                       W+              K  L++R++           D    +  A ++
Sbjct: 108 ------------WR--------------KTHLTYRIVNYTPDLPRDAVDSA--IEKALKV 139

Query: 205 WSEVTPLDFREDLAAPGAAVDIKLGFGRGRHLGCPRAFDGSGQEFAHAWR-----LGDIH 259
           W EVTPL F       G A DI + F    H G   +FDG G   AHA+       GDIH
Sbjct: 140 WEEVTPLTFSR--LYEGEA-DIMISFAVKEH-GDFYSFDGPGHSLAHAYPPGPGLYGDIH 195

Query: 260 FDDDEHFTPPTSDTGISLLKVAVHEIGHVLGLPHTYRTGSIMQPNY--IPQEPAFELDWS 317
           FDDDE +T   S T + L  VA HE+GH LGL H+  T ++M P Y    +   F L   
Sbjct: 196 FDDDEKWTEDASGTNLFL--VAAHELGHSLGLFHSANTEALMYPLYNSFTELAQFRLSQD 253

Query: 318 DRKAIQKLYGSCEGSFDT----------------------AFDWIRKERNQYGEVMVRFS 355
           D   IQ LYG    S +                       +FD I   R +Y        
Sbjct: 254 DVNGIQSLYGPPPASTEEPLVPTKSVPSGSEMPAKCDPALSFDAISTLRGEY-------- 305

Query: 356 TYFFRNSWYWLYENRNNRTRYGDPIQILTGWPGIPTHNIDAFVHIWTWKRDERYFFQGNQ 415
             FF++ ++W   + N    +     I   WP +P++ +DA   + +  RD  + F+GN+
Sbjct: 306 -LFFKDRYFWRRSHWNPEPEFH---LISAFWPSLPSY-LDAAYEVNS--RDTVFIFKGNE 358

Query: 416 YWRYDSDKDQALTEDEQGKSYPKLISE-GFPGIPSPLDTAFYDRRQKLIYFFKESLVFAF 474
           +W    ++ QA         YP+ I   GFP     +D A  D+ +K  YFF     + F
Sbjct: 359 FWAIRGNEVQA--------GYPRGIHTLGFPPTIRKIDAAVSDKEKKKTYFFAADKYWRF 410

Query: 475 DVNRNRVLNSYPKRITEVFPAVIPQNHPFRNIDSAYYSYAYNSIFFFKGNAYWKVVNDKD 534
           D N   +   +P+ I + FP V P+          +Y ++ +S F F  NA  ++V    
Sbjct: 411 DENSQSMEQGFPRLIADDFPGVEPKVDAVLQAFGFFYFFSGSSQFEFDPNA--RMVTHIL 468

Query: 535 KQQNSWL 541
           K  NSWL
Sbjct: 469 K-SNSWL 474


>gi|5729929 matrix metalloproteinase 24 preproprotein [Homo sapiens]
          Length = 645

 Score =  146 bits (369), Expect = 4e-35
 Identities = 146/515 (28%), Positives = 206/515 (40%), Gaps = 134/515 (26%)

Query: 84  ALAEAVRRFQRANALPASGELDAATLAAMNRPRCGVPDMRPPPPSAPPSPPGPPPRARSR 143
           AL  AV   Q+   +P +G LD  T+  M +PRCGVPD               P  +R R
Sbjct: 106 ALQSAVSTMQQFYGIPVTGVLDQTTIEWMKKPRCGVPD--------------HPHLSRRR 151

Query: 144 RSPRAPLSLSRRGWQPRGYPDGGAAQAFSKRTLSWRLLGEALSSQLSVADQRRIVALAFR 203
           R+ R  L+                 Q + ++ +++ +     + ++   D R+ +  AF 
Sbjct: 152 RNKRYALT----------------GQKWRQKHITYSI--HNYTPKVGELDTRKAIRQAFD 193

Query: 204 MWSEVTPLDFRE----DLAAPGAAVDIKLGFGRGRHLGCPRAFDGSGQEFAHAWRL---- 255
           +W +VTPL F E    ++ +     DI + F  G H G    FDG G   AHA+      
Sbjct: 194 VWQKVTPLTFEEVPYHEIKSDRKEADIMIFFASGFH-GDSSPFDGEGGFLAHAYFPGPGI 252

Query: 256 -GDIHFDDDEHFTPPTSD-TGISLLKVAVHEIGHVLGLPHTYRTGSIMQPNYIPQEP-AF 312
            GD HFD DE +T   ++  G  L  VAVHE+GH LGL H+    +IM P Y   E   F
Sbjct: 253 GGDTHFDSDEPWTLGNANHDGNDLFLVAVHELGHALGLEHSSDPSAIMAPFYQYMETHNF 312

Query: 313 ELDWSDRKAIQKLYGS-------------------------------------------- 328
           +L   D + IQK+YG                                             
Sbjct: 313 KLPQDDLQGIQKIYGPPAEPLEPTRPLPTLPVRRIHSPSERKHERQPRPPRPPLGDRPST 372

Query: 329 -------CEGSFDTAFDWIRKERNQYGEVMVRFSTYFFRNSWYWLYENRNNRTRYGDPIQ 381
                  C+G+F+T               + R   + F++ W+W    RNNR + G P+Q
Sbjct: 373 PGTKPNICDGNFNTV-------------ALFRGEMFVFKDRWFW--RLRNNRVQEGYPMQ 417

Query: 382 ILTGWPGIPTHNIDAFVHIWTWKRDERY-FFQGNQYWRYDSDKDQALTEDEQGKSYPKLI 440
           I   W G+P   IDA       + D R+ FF+G++YW           E      YP  +
Sbjct: 418 IEQFWKGLPA-RIDAAYE----RADGRFVFFKGDKYW--------VFKEVTVEPGYPHSL 464

Query: 441 SEGFPGIP-SPLDTAFYDRRQKLIYFFKESLVFAFDVNRNRVLNSYPKRITEVFPAVIPQ 499
            E    +P   +DTA         YFFK    + +   R      YPK IT V+   IPQ
Sbjct: 465 GELGSCLPREGIDTALRWEPVGKTYFFKGERYWRYSEERRATDPGYPKPIT-VWKG-IPQ 522

Query: 500 NHPFRNID-SAYYSYAYNSIFFFKGNAYWKVVNDK 533
                 I    YY+Y      F+KG  YWK  N K
Sbjct: 523 APQGAFISKEGYYTY------FYKGRDYWKFDNQK 551



 Score = 30.8 bits (68), Expect = 3.5
 Identities = 12/35 (34%), Positives = 18/35 (51%)

Query: 354 FSTYFFRNSWYWLYENRNNRTRYGDPIQILTGWPG 388
           + TYF++   YW ++N+      G P  IL  W G
Sbjct: 534 YYTYFYKGRDYWKFDNQKLSVEPGYPRNILRDWMG 568


>gi|73858572 matrix metalloproteinase 12 preproprotein [Homo
           sapiens]
          Length = 470

 Score =  142 bits (359), Expect = 6e-34
 Identities = 130/456 (28%), Positives = 203/456 (44%), Gaps = 79/456 (17%)

Query: 82  GAALAEAVRRFQRANALPASGELDAATLAAMNRPRCGVPDMRPPPPSAPPSPPGPPPRAR 141
           G  + E ++  Q    L  +G+LD +TL  M+ PRCGVPD+                   
Sbjct: 57  GNLMKEKIQEMQHFLGLKVTGQLDTSTLEMMHAPRCGVPDVH-----------------H 99

Query: 142 SRRSPRAPLSLSRRGWQPRGYPDGGAAQAFSKRTLSWRLLGEALSSQLSVADQRRIVALA 201
            R  P  P+      W+              K  +++R+     +  ++  D    +  A
Sbjct: 100 FREMPGGPV------WR--------------KHYITYRI--NNYTPDMNREDVDYAIRKA 137

Query: 202 FRMWSEVTPLDFREDLAAPGAAVDIKLGFGRGRHLGCPRAFDGSGQEFAHAWRLG----- 256
           F++WS VTPL F +         DI + F RG H G   AFDG G   AHA+  G     
Sbjct: 138 FQVWSNVTPLKFSK---INTGMADILVVFARGAH-GDFHAFDGKGGILAHAFGPGSGIGG 193

Query: 257 DIHFDDDEHFTPPTSDTGISLLKVAVHEIGHVLGLPHTYRTGSIMQPNYIPQE-PAFELD 315
           D HFD+DE +T  T   G +L   AVHEIGH LGL H+    ++M P Y   +   F L 
Sbjct: 194 DAHFDEDEFWT--THSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLS 251

Query: 316 WSDRKAIQKLYGSCEGSF-----DTAFDWIRKERNQYGEVM-VRFSTYFFRNSWYWLYEN 369
             D + IQ LYG  + +      D +   +      +  V  V    +FF++ ++WL  +
Sbjct: 252 ADDIRGIQSLYGDPKENQRLPNPDNSEPALCDPNLSFDAVTTVGNKIFFFKDRFFWLKVS 311

Query: 370 RNNRTRYGDPIQILTGWPGIPTHNIDAFVHIWTWKRDERYFFQGNQYWRYDSDKDQALTE 429
              +T       I + WP +P+  I+A   I    R++ + F+ ++YW   + + +    
Sbjct: 312 ERPKTSVN---LISSLWPTLPS-GIEAAYEIEA--RNQVFLFKDDKYWLISNLRPEP--- 362

Query: 430 DEQGKSYPKLI-SEGFPGIPSPLDTAFYDRRQKLIYFFKESLVFAFDVNRNRVLNSYPKR 488
                +YPK I S GFP     +D A ++ R    YFF ++  + +D  R  +   YPK 
Sbjct: 363 -----NYPKSIHSFGFPNFVKKIDAAVFNPRFYRTYFFVDNQYWRYDERRQMMDPGYPKL 417

Query: 489 ITEVFPAVIPQNHPFRNIDSAYYSYAYNSIFFFKGN 524
           IT+ F  + P+      ID+ +YS      +FF+G+
Sbjct: 418 ITKNFQGIGPK------IDAVFYS-KNKYYYFFQGS 446



 Score = 39.7 bits (91), Expect = 0.008
 Identities = 24/67 (35%), Positives = 33/67 (49%), Gaps = 4/67 (5%)

Query: 354 FSTYFFRNSWYWLYENRNNRTRYGDPIQILTGWPGIPTHNIDAFVHIWTWKRDERYFFQG 413
           + TYFF ++ YW Y+ R      G P  I   + GI    IDA   ++  K    YFFQG
Sbjct: 390 YRTYFFVDNQYWRYDERRQMMDPGYPKLITKNFQGIGP-KIDA---VFYSKNKYYYFFQG 445

Query: 414 NQYWRYD 420
           +  + YD
Sbjct: 446 SNQFEYD 452


>gi|13236530 matrix metalloproteinase 28 isoform 1 preproprotein
           [Homo sapiens]
          Length = 520

 Score =  138 bits (347), Expect = 2e-32
 Identities = 144/514 (28%), Positives = 206/514 (40%), Gaps = 98/514 (19%)

Query: 53  AQRFLSRYGWSGVWAAWGPSPEGPPETPKGAALAEAVRRFQRANALPASGELDAATLAAM 112
           A+ FL +YG+           E  P+ P     ++A+R FQ  + LP SG LD ATL  M
Sbjct: 36  AEAFLEKYGYLN---------EQVPKAPTSTRFSDAIRAFQWVSQLPVSGVLDRATLRQM 86

Query: 113 NRPRCGVPDMRPPPPSAPPSPPGPPPRARSRRSPRAPLSLSRRGWQPRGYPDGGAAQAFS 172
            RPRCGV D       A  +       AR R   R     +++G              + 
Sbjct: 87  TRPRCGVTDTN---SYAAWAERISDLFARHRTKMRRKKRFAKQG------------NKWY 131

Query: 173 KRTLSWRLLGEALSSQLSVADQRRIVALAFRMWSEVTPLDFREDLAAPGAAVDIKLGFGR 232
           K+ LS+RL+       L     R  V  AF++WS V+ L+F E  A      DI+L F +
Sbjct: 132 KQHLSYRLVN--WPEHLPEPAVRGAVRAAFQLWSNVSALEFWE--APATGPADIRLTFFQ 187

Query: 233 GRHL-GCPRAFDGSGQEFAHAW--RLGDIHFDDDEHFTPPTSDTGISLLKVAVHEIGHVL 289
           G H  G   AFDG G   AHA+  R G+ HFD DE ++  +   G +L  V  HEIGH L
Sbjct: 188 GDHNDGLGNAFDGPGGALAHAFLPRRGEAHFDQDERWS-LSRRRGRNLFVVLAHEIGHTL 246

Query: 290 GLPHTYRTGSIMQPNYIPQEPAFELDWSDRKAIQKLYGSCEG-------------SFDT- 335
           GL H+    ++M P Y        L W D  A+Q LYG   G              F+T 
Sbjct: 247 GLTHSPAPRALMAPYYKRLGRDALLSWDDVLAVQSLYGKPLGGSVAVQLPGKLFTDFETW 306

Query: 336 --------------------AFDWIRKERNQYGEVMVRFSTYFFRNSWYWLYENRNNRTR 375
                               +FD I  +R Q          Y F+ S +W      N   
Sbjct: 307 DSYSPQGRRPETQGPKYCHSSFDAITVDRQQ--------QLYIFKGSHFWEVAADGN--- 355

Query: 376 YGDPIQILTGWPGIPTHNIDAFVHIWTWKRDERYFFQGNQYWRYDSDKDQALTEDEQGKS 435
             +P  +   W G+P +   A V +      + YFF+G + WR+   K            
Sbjct: 356 VSEPRPLQERWVGLPPNIEAAAVSL---NDGDFYFFKGGRCWRFRGPKPV--------WG 404

Query: 436 YPKLISEGFPGIPSPLDTAFYDRRQKLIYFFKESLVFAFDVNRNRVLNSYPKRITEVFPA 495
            P+L   G  G+P   D A +    + +  FK +  +       +V   YP+ + +    
Sbjct: 405 LPQLCRAG--GLPRHPDAALFFPPLRRLILFKGARYYVLARGGLQVEPYYPRSLQDW--G 460

Query: 496 VIPQNHPFRNIDSAYYSYAYNSIFFFKGNAYWKV 529
            IP+        S        SI FF+ + YW++
Sbjct: 461 GIPEE------VSGALPRPDGSIIFFRDDRYWRL 488


>gi|11968059 matrix metalloproteinase 25 preproprotein [Homo
           sapiens]
          Length = 562

 Score =  135 bits (341), Expect = 8e-32
 Identities = 145/545 (26%), Positives = 214/545 (39%), Gaps = 115/545 (21%)

Query: 40  PLRQAKPIA-DLHAAQRFLSRYGWSGVWAAWGPSPEGPPETPKGAALAEAVRRFQRANAL 98
           P R  KP A D+     +L+RYG+        P      +      L +A++  QR   L
Sbjct: 18  PARAPKPSAQDVSLGVDWLTRYGYLP------PPHPAQAQLQSPEKLRDAIKVMQRFAGL 71

Query: 99  PASGELDAATLAAMNRPRCGVPDMRPPPPSAPPSPPGPPPRARSRRSPRAPLSLSRRGWQ 158
           P +G +D  T+A M +PRC +PD+            G     R RR      +LS   W+
Sbjct: 72  PETGRMDPGTVATMRKPRCSLPDVL-----------GVAGLVRRRRR----YALSGSVWK 116

Query: 159 PRGYPDGGAAQAFSKRTLSWRLLGEALSSQLSVADQRRIVALAFRMWSEVTPLDFREDLA 218
                         KRTL+WR+     SSQLS    R +++ A   W   + L F E  +
Sbjct: 117 --------------KRTLTWRVRSFPQSSQLSQETVRVLMSYALMAWGMESGLTFHEVDS 162

Query: 219 APGAAVDIKLGFGRGRHLGCPRAFDGSGQEFAHAW------RLGDIHFDDDEHFTPPTSD 272
             G   DI + F R  H      FDG G   AHA+        GD HFDD+E +T  + D
Sbjct: 163 PQGQEPDILIDFARAFHQD-SYPFDGLGGTLAHAFFPGEHPISGDTHFDDEETWTFGSKD 221

Query: 273 -TGISLLKVAVHEIGHVLGLPHTYRTGSIMQPNY---IPQEPAFELDWSDRKAIQKLYGS 328
             G  L  VAVHE GH LGL H+    SIM+P Y   +     + L   DR  +Q+LYG 
Sbjct: 222 GEGTDLFAVAVHEFGHALGLGHSSAPNSIMRPFYQGPVGDPDKYRLSQDDRDGLQQLYGK 281

Query: 329 -----------------------------------CEGSFDTAFDWIRKERNQYGEVMVR 353
                                              CEG+FD   +             +R
Sbjct: 282 APQTPYDKPTRKPLAPPPQPPASPTHSPSFPIPDRCEGNFDAIAN-------------IR 328

Query: 354 FSTYFFRNSWYWLYENRNNRTRYGDPIQILTGWPGIPTHNIDAFVHIWTWKRDER-YFFQ 412
             T+FF+  W+W  +  + +     P ++   W G+P   +      +   RD R   F 
Sbjct: 329 GETFFFKGPWFWRLQ-PSGQLVSPRPARLHRFWEGLPA-QVRVVQAAYARHRDGRILLFS 386

Query: 413 GNQYWRYDSDKDQALTEDEQGKSYPKLISEGFPGIPSPLDTAFYDRRQKLIYFFKESLVF 472
           G Q+W +   +D+ L    +G + P L   G P     +D  F   +    Y  +    +
Sbjct: 387 GPQFWVF---QDRQL----EGGARP-LTELGLPP-GEEVDAVFSWPQNGKTYLVRGRQYW 437

Query: 473 AFDVNRNRVLNSYPKRITEVFPAVIPQNHPFRNIDSAYYSYAYNSIFFFKGNAYWKVVND 532
            +D    R    YP+ ++ ++    P      + D    S A    +FFKG  YW+   +
Sbjct: 438 RYDEAAARPDPGYPRDLS-LWEGAPP------SPDDVTVSNA-GDTYFFKGAHYWRFPKN 489

Query: 533 KDKQQ 537
             K +
Sbjct: 490 SIKTE 494


>gi|4505221 matrix metalloproteinase 8 preproprotein [Homo sapiens]
          Length = 467

 Score =  130 bits (326), Expect = 4e-30
 Identities = 136/463 (29%), Positives = 194/463 (41%), Gaps = 102/463 (22%)

Query: 85  LAEAVRRFQRANALPASGELDAATLAAMNRPRCGVPDMRPPPPSAPPSPPGPPPRARSRR 144
           + E ++  QR   L  +G+ +  TL  M +PRCGVPD            PG P   R+  
Sbjct: 59  IVEKLKEMQRFFGLNVTGKPNEETLDMMKKPRCGVPDS-----GGFMLTPGNPKWERTNL 113

Query: 145 SPRAPLSLSRRGWQPRGYPDGGAAQAFSKRTLSWRLLGEALSSQLSVADQRRIVALAFRM 204
           + R       R + P                            QLS A+  R +  AF +
Sbjct: 114 TYRI------RNYTP----------------------------QLSEAEVERAIKDAFEL 139

Query: 205 WSEVTPLDFREDLAAPGAAVDIKLGFGRGRHLGCPRAFDGSGQEFAHAWRLG-----DIH 259
           WS  +PL F     + G A DI + F +  H G    FDG     AHA++ G     D H
Sbjct: 140 WSVASPLIFTR--ISQGEA-DINIAFYQRDH-GDNSPFDGPNGILAHAFQPGQGIGGDAH 195

Query: 260 FDDDEHFTPPTSDTGISLLKVAVHEIGHVLGLPHTYRTGSIMQPNYIPQEPA-FELDWSD 318
           FD +E +T   +    +L  VA HE GH LGL H+   G++M PNY  +E + + L   D
Sbjct: 196 FDAEETWT--NTSANYNLFLVAAHEFGHSLGLAHSSDPGALMYPNYAFRETSNYSLPQDD 253

Query: 319 RKAIQKLYG---------------SCEGSFDTAFDWIRKERNQYGEVMVRFSTYFFRNSW 363
              IQ +YG                C+ S    FD I   R   GE++      FF++ +
Sbjct: 254 IDGIQAIYGLSSNPIQPTGPSTPKPCDPSL--TFDAITTLR---GEIL------FFKDRY 302

Query: 364 YWLYENRNNRTRYGDPIQILTGWPGIPTHNIDAFVHIWTWKRDERYFFQGNQYWRYDSDK 423
           +W    R+ + +  +   I   WP +PT    A+     + RD  + F+GNQYW      
Sbjct: 303 FW---RRHPQLQRVEMNFISLFWPSLPTGIQAAYE---DFDRDLIFLFKGNQYW------ 350

Query: 424 DQALTEDEQGKSYPKLISE-GFPGIPSPLDTAFYDRRQKLIYFFKESLVFAFDVNRNRVL 482
             AL+  +  + YPK IS  GFP     +D A + R +   YFF     + +D  R  + 
Sbjct: 351 --ALSGYDILQGYPKDISNYGFPSSVQAIDAAVFYRSK--TYFFVNDQFWRYDNQRQFME 406

Query: 483 NSYPKRITEVFP-------AVIPQNHPFRNIDSAYYSYAYNSI 518
             YPK I+  FP       AV  Q H F       Y YA++ I
Sbjct: 407 PGYPKSISGAFPGIESKVDAVFQQEHFFHVFSGPRY-YAFDLI 448



 Score = 30.0 bits (66), Expect = 5.9
 Identities = 25/87 (28%), Positives = 35/87 (40%), Gaps = 13/87 (14%)

Query: 445 PGIPSPLDTAF-YDRRQKL---IYFFKESLVFAFDVNRNRVLNSYPKRITEVFPAVIPQN 500
           P  P P D +  +D    L   I FFK+   +     R+  L         +F   +P  
Sbjct: 273 PSTPKPCDPSLTFDAITTLRGEILFFKDRYFW----RRHPQLQRVEMNFISLFWPSLPTG 328

Query: 501 HPFRNIDSAYYSYAYNSIFFFKGNAYW 527
                I +AY  +  + IF FKGN YW
Sbjct: 329 -----IQAAYEDFDRDLIFLFKGNQYW 350


>gi|13027802 matrix metalloproteinase 16 isoform 1 preproprotein
           [Homo sapiens]
          Length = 607

 Score =  130 bits (326), Expect = 4e-30
 Identities = 143/526 (27%), Positives = 211/526 (40%), Gaps = 137/526 (26%)

Query: 76  PPETPKGAALAEA------VRRFQRANALPASGELDAATLAAMNRPRCGVPDMRPPPPSA 129
           PP  P+ + L  A      +   Q+   +  +G++D  T+  M +PRCGVPD        
Sbjct: 54  PPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQT------ 107

Query: 130 PPSPPGPPPRARSR-RSPRAPLSLSRRGWQPRGYPDGGAAQAFSKRTLSWRLLGEALSSQ 188
                    R  S+    R   +L+ + WQ               + +++ +  + ++ +
Sbjct: 108 ---------RGSSKFHIRRKRYALTGQKWQ--------------HKHITYSI--KNVTPK 142

Query: 189 LSVADQRRIVALAFRMWSEVTPLDFRE----DLAAPGAAVDIKLGFGRGRHLGCPRAFDG 244
           +   + R+ +  AF +W  VTPL F E    +L      VDI + F  G H G    FDG
Sbjct: 143 VGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVDITIIFASGFH-GDSSPFDG 201

Query: 245 SGQEFAHAWRLG-----DIHFDDDEHFT--PPTSDTGISLLKVAVHEIGHVLGLPHTYRT 297
            G   AHA+  G     D HFD DE +T   P  D G  L  VAVHE+GH LGL H+   
Sbjct: 202 EGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHD-GNDLFLVAVHELGHALGLEHSNDP 260

Query: 298 GSIMQPNYIPQE-PAFELDWSDRKAIQKLYGS---------------------------- 328
            +IM P Y   E   F+L   D + IQK+YG                             
Sbjct: 261 TAIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKN 320

Query: 329 ----------------------CEGSFDTAFDWIRKERNQYGEVMVRFSTYFFRNSWYWL 366
                                 C+G+F+T               ++R   + F++ W+W 
Sbjct: 321 DRPKPPRPPTGRPSYPGAKPNICDGNFNTL-------------AILRREMFVFKDQWFW- 366

Query: 367 YENRNNRTRYGDPIQILTGWPGIPTHNIDAFVHIWTWKRDERYFFQGNQYWRYDSDKDQA 426
              RNNR   G P+QI   W G+P  +IDA   ++        FF+GN+YW +   KD  
Sbjct: 367 -RVRNNRVMDGYPMQITYFWRGLPP-SIDA---VYENSDGNFVFFKGNKYWVF---KDTT 418

Query: 427 LTEDEQGKSYP-KLISEGFPGIPSPLDTAFYDRRQKLIYFFKESLVFAFDVNRNRVLNSY 485
           L        YP  LI+ G    P  +D+A +       YFFK    + +      +   Y
Sbjct: 419 LQ-----PGYPHDLITLGSGIPPHGIDSAIWWEDVGKTYFFKGDRYWRYSEEMKTMDPGY 473

Query: 486 PKRITEVFPAVIPQNHPFRNIDSAYYSYAYNSIFFFKGNAYWKVVN 531
           PK IT V+   IP++        A+        +F+KG  YWK  N
Sbjct: 474 PKPIT-VWKG-IPESP-----QGAFVHKENGFTYFYKGKEYWKFNN 512



 Score = 64.3 bits (155), Expect = 3e-10
 Identities = 43/136 (31%), Positives = 68/136 (50%), Gaps = 11/136 (8%)

Query: 358 FFRNSWYWLYENRNNRTRYGDPIQILTGWPGIPTHNIDAFVHIWTWKRDERYFFQGNQYW 417
           FF+ + YW++++   +  Y  P  ++T   GIP H ID+   IW     + YFF+G++YW
Sbjct: 405 FFKGNKYWVFKDTTLQPGY--PHDLITLGSGIPPHGIDSA--IWWEDVGKTYFFKGDRYW 460

Query: 418 RYDSDKDQALTEDEQGKSYPKLISEGFPGIPSPLDTAFYDRRQKLIYFFKESLVFAFDVN 477
           RY    ++  T D     YPK I+  + GIP     AF  +     YF+K    + F+  
Sbjct: 461 RYS---EEMKTMDP---GYPKPITV-WKGIPESPQGAFVHKENGFTYFYKGKEYWKFNNQ 513

Query: 478 RNRVLNSYPKRITEVF 493
             +V   YP+ I + F
Sbjct: 514 ILKVEPGYPRSILKDF 529


>gi|58331148 matrix metalloproteinase 11 preproprotein [Homo
           sapiens]
          Length = 488

 Score =  129 bits (324), Expect = 7e-30
 Identities = 134/453 (29%), Positives = 178/453 (39%), Gaps = 99/453 (21%)

Query: 124 PPPPSAPPSPPGPPPRARSRRSPRAPL-----SLSRRGWQPRGYPDGGAAQAFSKRTLSW 178
           P  P+  P+    P  A S R PR  +      LS R  Q R    GG    + K  L++
Sbjct: 56  PSSPAPAPATQEAPRPASSLRPPRCGVPDPSDGLSARNRQKRFVLSGGR---WEKTDLTY 112

Query: 179 RLLGEALSSQLSVADQRRIVALAFRMWSEVTPLDFREDLAAPGAAVDIKLGFGRGRHLGC 238
           R+L      QL     R+ +A A ++WS+VTPL F E         DI + F R  H G 
Sbjct: 113 RIL--RFPWQLVQEQVRQTMAEALKVWSDVTPLTFTE---VHEGRADIMIDFARYWH-GD 166

Query: 239 PRAFDGSGQEFAHAW-----RLGDIHFDDDEHFTPPTSDTGISLLKVAVHEIGHVLGLPH 293
              FDG G   AHA+     R GD+HFD DE +T    D G  LL+VA HE GHVLGL H
Sbjct: 167 DLPFDGPGGILAHAFFPKTHREGDVHFDYDETWTIG-DDQGTDLLQVAAHEFGHVLGLQH 225

Query: 294 TYRTGSIMQPNYIPQEPAFELDWSDRKAIQKLYG-------------------------- 327
           T    ++M   Y  + P   L   D + +Q LYG                          
Sbjct: 226 TTAAKALMSAFYTFRYP-LSLSPDDCRGVQHLYGQPWPTVTSRTPALGPQAGIDTNEIAP 284

Query: 328 --------SCEGSFDTAFDWIRKERNQYGEVMVRFSTYFFRNSWYWLYENRNNRTRYGDP 379
                   +CE SFD                 +R   +FF+  + W    R  + + G P
Sbjct: 285 LEPDAPPDACEASFDAV-------------STIRGELFFFKAGFVW--RLRGGQLQPGYP 329

Query: 380 IQILTGWPGIPTHNIDAFV----HIWTWKRDERYFFQGNQYWRYDSDKDQALTEDEQGKS 435
                 W G+P+    AF     HIW        FFQG QYW YD +K            
Sbjct: 330 ALASRHWQGLPSPVDAAFEDAQGHIW--------FFQGAQYWVYDGEKPVL--------G 373

Query: 436 YPKLISEGFPGIPSPLDTAFYDRRQKLIYFFKESLVFAFDVNRNRVLNSYPKRITEVFPA 495
              L   G    P      +   + K IYFF+    + F  +  RV +  P+R T+    
Sbjct: 374 PAPLTELGLVRFPVHAALVWGPEKNK-IYFFRGRDYWRFHPSTRRVDSPVPRRATDWRGV 432

Query: 496 VIPQNHPFRNIDSAYYSYAYNSIFFFKGNAYWK 528
               +  F++ D     YAY    F +G  YWK
Sbjct: 433 PSEIDAAFQDAD----GYAY----FLRGRLYWK 457


>gi|4505215 matrix metalloproteinase 1 isoform 1 preproprotein [Homo
           sapiens]
          Length = 469

 Score =  128 bits (321), Expect = 2e-29
 Identities = 126/453 (27%), Positives = 180/453 (39%), Gaps = 112/453 (24%)

Query: 85  LAEAVRRFQRANALPASGELDAATLAAMNRPRCGVPDMRPPPPSAPPSPPGPPPRARSRR 144
           + E +++ Q    L  +G+ DA TL  M +PRCGVPD+                   +  
Sbjct: 60  VVEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQ--------------FVLTEG 105

Query: 145 SPRAPLSLSRRGWQPRGYPDGGAAQAFSKRTLSWRLLGEALSSQLSVADQRRIVALAFRM 204
           +PR         W+              +  L++R+  E  +  L  AD    +  AF++
Sbjct: 106 NPR---------WE--------------QTHLTYRI--ENYTPDLPRADVDHAIEKAFQL 140

Query: 205 WSEVTPLDFREDLAAPGAAVDIKLGFGRGRHLGCPRAFDGSGQEFAHAWRLG-----DIH 259
           WS VTPL F +   + G A DI + F RG H      FDG G   AHA++ G     D H
Sbjct: 141 WSNVTPLTFTK--VSEGQA-DIMISFVRGDHRD-NSPFDGPGGNLAHAFQPGPGIGGDAH 196

Query: 260 FDDDEHFTPPTSDTGISLLKVAVHEIGHVLGLPHTYRTGSIMQPNYIPQEPAFELDWSDR 319
           FD+DE +T    +   +L +VA HE+GH LGL H+   G++M P+Y       +L   D 
Sbjct: 197 FDEDERWTNNFRE--YNLHRVAAHELGHSLGLSHSTDIGALMYPSYTFSGDV-QLAQDDI 253

Query: 320 KAIQKLYGSCEGSFD-------------TAFDWIRKERNQ---------------YGEVM 351
             IQ +YG  +                   FD I   R +               Y EV 
Sbjct: 254 DGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDRFYMRTNPFYPEVE 313

Query: 352 VRF----------------------STYFFRNSWYWLYENRNNRTRYGDPIQILTGWPGI 389
           + F                         FF+ + YW  + +N    Y   I    G+P  
Sbjct: 314 LNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGYPKDIYSSFGFPRT 373

Query: 390 PTHNIDAFVHIWTWKRDERYFFQGNQYWRYDSDKDQALTEDEQGKSYPKLISEGFPGIPS 449
             H IDA +        + YFF  N+YWRYD  K            YPK+I+  FPGI  
Sbjct: 374 VKH-IDAALS--EENTGKTYFFVANKYWRYDEYK------RSMDPGYPKMIAHDFPGIGH 424

Query: 450 PLDTAFYDRRQKLIYFFKESLVFAFDVNRNRVL 482
            +D  F   +    YFF  +  + FD    R+L
Sbjct: 425 KVDAVF--MKDGFFYFFHGTRQYKFDPKTKRIL 455


>gi|45359865 matrix metalloproteinase 20 preproprotein [Homo
           sapiens]
          Length = 483

 Score =  127 bits (318), Expect = 4e-29
 Identities = 130/494 (26%), Positives = 197/494 (39%), Gaps = 115/494 (23%)

Query: 84  ALAEAVRRFQRANALPASGELDAATLAAMNRPRCGVPDMRPPPPSAPPSPPGPPPRARSR 143
           ++   ++  Q    L  +G+LD  T+  + +PRCGVPD+                 A  R
Sbjct: 67  SMIRKIKELQAFFGLQVTGKLDQTTMNVIKKPRCGVPDV-----------------ANYR 109

Query: 144 RSPRAPLSLSRRGWQPRGYPDGGAAQAFSKRTLSWRLLGEALSSQLSVADQRRIVALAFR 203
             P  P                     + K TL++R+     +  +S  +  + V +A +
Sbjct: 110 LFPGEP--------------------KWKKNTLTYRI--SKYTPSMSSVEVDKAVEMALQ 147

Query: 204 MWSEVTPLDFREDLAAPGAAVDIKLGFGRGRHLGCPRAFDGSGQEFAHAWRLG-----DI 258
            WS   PL F   +       DI + F  G H G    FDG     AHA+  G     D 
Sbjct: 148 AWSSAVPLSF---VRINSGEADIMISFENGDH-GDSYPFDGPRGTLAHAFAPGEGLGGDT 203

Query: 259 HFDDDEHFTPPTSDTGISLLKVAVHEIGHVLGLPHTYRTGSIMQPNYIPQEP-AFELDWS 317
           HFD+ E +T  T+  G +L  VA HE GH LGL H+    ++M P Y  + P  F L   
Sbjct: 204 HFDNAEKWTMGTN--GFNLFTVAAHEFGHALGLAHSTDPSALMYPTYKYKNPYGFHLPKD 261

Query: 318 DRKAIQKLYGS-----------------------CEGSFDTAFDWIRKERNQYGEVMVRF 354
           D K IQ LYG                        C+ S  ++FD +          M+  
Sbjct: 262 DVKGIQALYGPRKVFLGKPTLPHAPHHKPSIPDLCDSS--SSFDAV---------TMLGK 310

Query: 355 STYFFRNSWYWLYENRNNRTRYG-DPIQILTGWPGIPTHNIDAFVHIWTWKRDERYFFQG 413
               F++  +W    R    R G  P  I + +P + + N+DA   +   +R   YFF+G
Sbjct: 311 ELLLFKDRIFW---RRQVHLRTGIRPSTITSSFPQLMS-NVDAAYEV--AERGTAYFFKG 364

Query: 414 NQYWRYDSDKDQALTEDEQGKSYPKLISE-GFPGIPSPLDTAFYDRRQKLIYFFKESLVF 472
             YW         +T   Q +  P+ I + GFP     +D A Y R  +   FF     +
Sbjct: 365 PHYW---------ITRGFQMQGPPRTIYDFGFPRHVQQIDAAVYLREPQKTLFFVGDEYY 415

Query: 473 AFDVNRNRVLNSYPKRITEVFPAVIPQNHPFRNIDSAYYSYAYNSIFFFKGNAYWKVVND 532
           ++D  + ++   YPK   E F  V  Q      ID+A     Y  I+FF G   +K   +
Sbjct: 416 SYDERKRKMEKDYPKNTEEEFSGVNGQ------IDAAVELNGY--IYFFSGPKTYKYDTE 467

Query: 533 KDK-----QQNSWL 541
           K+      + +SW+
Sbjct: 468 KEDVVSVVKSSSWI 481


>gi|4505209 matrix metalloproteinase 13 preproprotein [Homo sapiens]
          Length = 471

 Score =  126 bits (317), Expect = 5e-29
 Identities = 138/498 (27%), Positives = 197/498 (39%), Gaps = 128/498 (25%)

Query: 49  DLHAAQRFLSRYGWSGVWAAWGPSP-EGPPETPKGAALAEAVRRFQRANALPASGELDAA 107
           DL  A+R+L  Y        + P+   G  +    +++ E +R  Q    L  +G+LD  
Sbjct: 35  DLQFAERYLRSY--------YHPTNLAGILKENAASSMTERLREMQSFFGLEVTGKLDDN 86

Query: 108 TLAAMNRPRCGVPDMRPPPPSAPPSPPGPPPRARSRRSPRAPLSLSRRGWQPRGYPDGGA 167
           TL  M +PRCGVPD+                       PR                    
Sbjct: 87  TLDVMKKPRCGVPDV-----------------GEYNVFPRT------------------- 110

Query: 168 AQAFSKRTLSWRLLGEALSSQLSVADQRRIVALAFRMWSEVTPLDFREDLAAPGAAVDIK 227
              +SK  L++R++    +  ++ ++  +    AF++WS+VTPL+F           DI 
Sbjct: 111 -LKWSKMNLTYRIVN--YTPDMTHSEVEKAFKKAFKVWSDVTPLNFTR---LHDGIADIM 164

Query: 228 LGFGRGRHLGCPRAFDGSGQEFAHAWRLG-----DIHFDDDEHFTPPTSDTGISLLKVAV 282
           + FG   H G    FDG     AHA+  G     D HFDDDE +T  +S  G +L  VA 
Sbjct: 165 ISFGIKEH-GDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWT--SSSKGYNLFLVAA 221

Query: 283 HEIGHVLGLPHTYRTGSIMQPNY-IPQEPAFELDWSDRKAIQKLYG-------------- 327
           HE GH LGL H+   G++M P Y    +  F L   D + IQ LYG              
Sbjct: 222 HEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDDVQGIQSLYGPGDEDPNPKHPKTP 281

Query: 328 -SCEGSFDTAFDWIRKERNQYGEVMVRFSTYFFR------------NSWYW--------- 365
             C+ S   + D I   R   GE M+    +F+R               +W         
Sbjct: 282 DKCDPSL--SLDAITSLR---GETMIFKDRFFWRLHPQQVDAELFLTKSFWPELPNRIDA 336

Query: 366 LYEN---------RNNRTRYGDPIQILTGWP------GIP--THNIDAFVHIWTWKRDER 408
            YE+         R  +    +   IL G+P      G+P     I A VH       + 
Sbjct: 337 AYEHPSHDLIFIFRGRKFWALNGYDILEGYPKKISELGLPKEVKKISAAVHF--EDTGKT 394

Query: 409 YFFQGNQYWRYDSDKDQALTEDEQGKSYPKLISEGFPGIPSPLDTAFYDRRQKLIYFFKE 468
             F GNQ WRYD       T     K YP+LI E FPGI   +D  +   +   IYFF  
Sbjct: 395 LLFSGNQVWRYDD------TNHIMDKDYPRLIEEDFPGIGDKVDAVY--EKNGYIYFFNG 446

Query: 469 SLVFAFDVNRNRVLNSYP 486
            + F + +  NR++   P
Sbjct: 447 PIQFEYSIWSNRIVRVMP 464


>gi|225543094 matrix metalloproteinase 1 isoform 2 [Homo sapiens]
          Length = 403

 Score =  124 bits (312), Expect = 2e-28
 Identities = 124/440 (28%), Positives = 174/440 (39%), Gaps = 112/440 (25%)

Query: 98  LPASGELDAATLAAMNRPRCGVPDMRPPPPSAPPSPPGPPPRARSRRSPRAPLSLSRRGW 157
           L  +G+ DA TL  M +PRCGVPD+                   +  +PR         W
Sbjct: 7   LKVTGKPDAETLKVMKQPRCGVPDVAQ--------------FVLTEGNPR---------W 43

Query: 158 QPRGYPDGGAAQAFSKRTLSWRLLGEALSSQLSVADQRRIVALAFRMWSEVTPLDFREDL 217
           +              +  L++R+  E  +  L  AD    +  AF++WS VTPL F +  
Sbjct: 44  E--------------QTHLTYRI--ENYTPDLPRADVDHAIEKAFQLWSNVTPLTFTK-- 85

Query: 218 AAPGAAVDIKLGFGRGRHLGCPRAFDGSGQEFAHAWRLG-----DIHFDDDEHFTPPTSD 272
            + G A DI + F RG H      FDG G   AHA++ G     D HFD+DE +T    +
Sbjct: 86  VSEGQA-DIMISFVRGDHRD-NSPFDGPGGNLAHAFQPGPGIGGDAHFDEDERWTNNFRE 143

Query: 273 TGISLLKVAVHEIGHVLGLPHTYRTGSIMQPNYIPQEPAFELDWSDRKAIQKLYGSCEGS 332
              +L +VA HE+GH LGL H+   G++M P+Y       +L   D   IQ +YG  +  
Sbjct: 144 --YNLHRVAAHELGHSLGLSHSTDIGALMYPSYTFSGDV-QLAQDDIDGIQAIYGRSQNP 200

Query: 333 FD-------------TAFDWIRKERNQ---------------YGEVMVRF---------- 354
                            FD I   R +               Y EV + F          
Sbjct: 201 VQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDRFYMRTNPFYPEVELNFISVFWPQLPN 260

Query: 355 ------------STYFFRNSWYWLYENRNNRTRYGDPIQILTGWPGIPTHNIDAFVHIWT 402
                          FF+ + YW  + +N    Y   I    G+P    H IDA +    
Sbjct: 261 GLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGYPKDIYSSFGFPRTVKH-IDAALS--E 317

Query: 403 WKRDERYFFQGNQYWRYDSDKDQALTEDEQGKSYPKLISEGFPGIPSPLDTAFYDRRQKL 462
               + YFF  N+YWRYD  K            YPK+I+  FPGI   +D  F   +   
Sbjct: 318 ENTGKTYFFVANKYWRYDEYK------RSMDPGYPKMIAHDFPGIGHKVDAVF--MKDGF 369

Query: 463 IYFFKESLVFAFDVNRNRVL 482
            YFF  +  + FD    R+L
Sbjct: 370 FYFFHGTRQYKFDPKTKRIL 389


>gi|73808268 matrix metalloproteinase 27 [Homo sapiens]
          Length = 513

 Score =  124 bits (312), Expect = 2e-28
 Identities = 124/458 (27%), Positives = 184/458 (40%), Gaps = 104/458 (22%)

Query: 87  EAVRRFQRANALPASGELDAATLAAMNRPRCGVPDMRPPPPSAPPSPPGPPPRARSRRSP 146
           + +R  Q    L  +G+LD+ TL  M  PRCGVPD+     + P                
Sbjct: 61  DKIREMQAFFGLTVTGKLDSNTLEIMKTPRCGVPDVGQYGYTLP---------------- 104

Query: 147 RAPLSLSRRGWQPRGYPDGGAAQAFSKRTLSWRLLGEALSSQLSVADQRRIVALAFRMWS 206
                    GW+              K  L++R++        +  D+   +     +WS
Sbjct: 105 ---------GWR--------------KYNLTYRIINYTPDMARAAVDEA--IQEGLEVWS 139

Query: 207 EVTPLDFREDLAAPGAAVDIKLGFGRGRHLGCPRAFDGSGQEFAHAWRLG-----DIHFD 261
           +VTPL F +   + G A DI + F    H  CPR FDG      HA+  G     D HFD
Sbjct: 140 KVTPLKFTK--ISKGIA-DIMIAFRTRVHGRCPRYFDGPLGVLGHAFPPGPGLGGDTHFD 196

Query: 262 DDEHFTPPTSDTGISLLKVAVHEIGHVLGLPHTYRTGSIMQPNYIPQEP-AFELDWSDRK 320
           +DE++T      G +L  VA HE GH LGL H+    ++M PNY+  +P  + L   D  
Sbjct: 197 EDENWTK--DGAGFNLFLVAAHEFGHALGLSHSNDQTALMFPNYVSLDPRKYPLSQDDIN 254

Query: 321 AIQKLYG----------------SCEGSFDTAFDWIRKERNQYGEVMVRFSTYFFRNSWY 364
            IQ +YG                +C+   D  FD I   R    EVM      FF+    
Sbjct: 255 GIQSIYGGLPKEPAKPKEPTIPHACDP--DLTFDAITTFRR---EVM------FFKGRHL 303

Query: 365 WLYENRNNRTRYGDPIQILTGWPGIPTHNIDAFVHIWTWKRDERYFFQGNQYWRYDSDKD 424
           W          +     I + WP +P     A+ +     RD+   F+   +W     + 
Sbjct: 304 WRIYYDITDVEFE---LIASFWPSLPADLQAAYEN----PRDKILVFKDENFWMI---RG 353

Query: 425 QALTEDEQGKSYPKLI-SEGFPGIPSPLDTAFYDRRQKLIYFFKESLVFAFDVNRNRVLN 483
            A+  D     YPK I + GFPG    +D A  D+  +  YFF     + FD     +  
Sbjct: 354 YAVLPD-----YPKSIHTLGFPGRVKKIDAAVCDKTTRKTYFFVGIWCWRFDEMTQTMDK 408

Query: 484 SYPKRITEVFPAVIPQNHPFRNIDSAYYSYAYNSIFFF 521
            +P+R+ + FP +  +      +D+A   + Y   FFF
Sbjct: 409 GFPQRVVKHFPGISIR------VDAA---FQYKGFFFF 437


>gi|4505219 matrix metalloproteinase 7 preproprotein [Homo sapiens]
          Length = 267

 Score =  108 bits (270), Expect = 1e-23
 Identities = 80/261 (30%), Positives = 117/261 (44%), Gaps = 50/261 (19%)

Query: 78  ETPKGAALAEAVRRFQRANALPASGELDAATLAAMNRPRCGVPDMRPPPPSAPPSPPGPP 137
           ET    +L   ++  Q+   LP +G L++  +  M +PRCGVPD+               
Sbjct: 48  ETKNANSLEAKLKEMQKFFGLPITGMLNSRVIEIMQKPRCGVPDV--------------- 92

Query: 138 PRARSRRSPRAPLSLSRRGWQPRGYPDGGAAQAFSKRTLSWRLLGEALSSQLSVADQRRI 197
             A     P +P                     ++ + +++R++           D  R+
Sbjct: 93  --AEYSLFPNSP--------------------KWTSKVVTYRIVSYTRDLPHITVD--RL 128

Query: 198 VALAFRMWSEVTPLDFREDLAAPGAAVDIKLGFGRGRHLGCPRAFDGSGQEFAHAWRLG- 256
           V+ A  MW +  PL FR+ +       DI +GF RG H G    FDG G   AHA+  G 
Sbjct: 129 VSKALNMWGKEIPLHFRKVV---WGTADIMIGFARGAH-GDSYPFDGPGNTLAHAFAPGT 184

Query: 257 ----DIHFDDDEHFTPPTSDTGISLLKVAVHEIGHVLGLPHTYRTGSIMQPNYIPQEPA- 311
               D HFD+DE +T  +S  GI+ L  A HE+GH LG+ H+    ++M P Y   +P  
Sbjct: 185 GLGGDAHFDEDERWTDGSS-LGINFLYAATHELGHSLGMGHSSDPNAVMYPTYGNGDPQN 243

Query: 312 FELDWSDRKAIQKLYGSCEGS 332
           F+L   D K IQKLYG    S
Sbjct: 244 FKLSQDDIKGIQKLYGKRSNS 264


>gi|4505211 matrix metalloproteinase 15 preproprotein [Homo sapiens]
          Length = 669

 Score =  107 bits (267), Expect = 3e-23
 Identities = 102/297 (34%), Positives = 137/297 (46%), Gaps = 50/297 (16%)

Query: 48  ADLHAAQRFLSRYGWSGVWAAWGPSPEGPPETPKGAA-LAEAVRRFQRANALPASGELDA 106
           A++HA + +L  YG+        P P     T + A  LA A+   QR   +P +G LD 
Sbjct: 49  AEVHA-ENWLRLYGYL-------PQPSRHMSTMRSAQILASALAEMQRFYGIPVTGVLDE 100

Query: 107 ATLAAMNRPRCGVPDMRPPPPSAPPSPPGPPPRARSRRSPRAPLSLSRRGWQPRGYPDGG 166
            T   M RPRCGVPD             G   +A  RR  R   +L+ R W         
Sbjct: 101 ETKEWMKRPRCGVPDQF-----------GVRVKANLRRR-RKRYALTGRKWNNH------ 142

Query: 167 AAQAFSKRTLSWRLLGEALSSQLSVADQRRIVALAFRMWSEVTPLDFR----EDL-AAPG 221
                   T S +   E L    S+   RR    AFR+W + TPL F+    ED+     
Sbjct: 143 ------HLTFSIQNYTEKLGWYHSMEAVRR----AFRVWEQATPLVFQEVPYEDIRLRRQ 192

Query: 222 AAVDIKLGFGRGRHLGCPRAFDGSGQEFAHAW-----RLGDIHFDDDEHFTPPTSDT-GI 275
              DI + F  G H G    FDG+G   AHA+       GD HFD DE +T  ++D  G 
Sbjct: 193 KEADIMVLFASGFH-GDSSPFDGTGGFLAHAYFPGPGLGGDTHFDADEPWTFSSTDLHGN 251

Query: 276 SLLKVAVHEIGHVLGLPHTYRTGSIMQPNYIPQE-PAFELDWSDRKAIQKLYGSCEG 331
           +L  VAVHE+GH LGL H+    +IM P Y  ++   F+L   D + IQ+LYG+ +G
Sbjct: 252 NLFLVAVHELGHALGLEHSSNPNAIMAPFYQWKDVDNFKLPEDDLRGIQQLYGTPDG 308



 Score = 66.6 bits (161), Expect = 6e-11
 Identities = 60/238 (25%), Positives = 98/238 (41%), Gaps = 46/238 (19%)

Query: 329 CEGSFDTAFDWIRKERNQYGEVMVRFSTYFFRNSWYWLYENRNNRTRYGDPIQILTGWPG 388
           C+G FDT               M+R   + F+  W+W    R+NR     P+ I   W G
Sbjct: 370 CDGDFDTV-------------AMLRGEMFVFKGRWFWRV--RHNRVLDNYPMPIGHFWRG 414

Query: 389 IPTHNIDAFVHIWTWKRDERY-FFQGNQYWRYDSDKDQALTEDEQGKSYPKLISEGFPGI 447
           +P     A+      ++D R+ FF+G++YW +         E      YP+ ++    GI
Sbjct: 415 LPGDISAAYE-----RQDGRFVFFKGDRYWLF--------REANLEPGYPQPLTSYGLGI 461

Query: 448 P-SPLDTAFYDRRQKLIYFFKESLVFAFDVNRNRVLNSYPKRITEVFPAVIPQNHPFRNI 506
           P   +DTA +       +FF+E   + F+    R    YPK I+            F + 
Sbjct: 462 PYDRIDTAIWWEPTGHTFFFQEDRYWRFNEETQRGDPGYPKPISVWQGIPASPKGAFLSN 521

Query: 507 DSAYYSYAYNSIFFFKGNAYWKVVNDKDKQQNSWLPANGLFPKKFISEKWFDVCDVHI 564
           D+AY        +F+KG  YWK  N++ + +         +PK  + +  F  C  H+
Sbjct: 522 DAAY-------TYFYKGTKYWKFDNERLRMEPG-------YPKSILRD--FMGCQEHV 563



 Score = 35.4 bits (80), Expect = 0.14
 Identities = 21/66 (31%), Positives = 25/66 (37%)

Query: 89  VRRFQRANALPASGELDAATLAAMNRPRCGVPDMRPPPPSAPPSPPGPPPRARSRRSPRA 148
           +R  Q+    P         L  +   R G PD RPP P  PP P G P R      P  
Sbjct: 296 LRGIQQLYGTPDGQPQPTQPLPTVTPRRPGRPDHRPPRPPQPPPPGGKPERPPKPGPPVQ 355

Query: 149 PLSLSR 154
           P +  R
Sbjct: 356 PRATER 361


>gi|149999365 matrix metalloproteinase 16 isoform 2 preproprotein
           [Homo sapiens]
          Length = 457

 Score =  102 bits (254), Expect = 9e-22
 Identities = 106/390 (27%), Positives = 156/390 (40%), Gaps = 118/390 (30%)

Query: 76  PPETPKGAALAEA------VRRFQRANALPASGELDAATLAAMNRPRCGVPDMRPPPPSA 129
           PP  P+ + L  A      +   Q+   +  +G++D  T+  M +PRCGVPD        
Sbjct: 54  PPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQT------ 107

Query: 130 PPSPPGPPPRARSR-RSPRAPLSLSRRGWQPRGYPDGGAAQAFSKRTLSWRLLGEALSSQ 188
                    R  S+    R   +L+ + WQ               + +++ +  + ++ +
Sbjct: 108 ---------RGSSKFHIRRKRYALTGQKWQ--------------HKHITYSI--KNVTPK 142

Query: 189 LSVADQRRIVALAFRMWSEVTPLDFRE----DLAAPGAAVDIKLGFGRGRHLGCPRAFDG 244
           +   + R+ +  AF +W  VTPL F E    +L      VDI + F  G H G    FDG
Sbjct: 143 VGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVDITIIFASGFH-GDSSPFDG 201

Query: 245 SGQEFAHAWRLG-----DIHFDDDEHFT--PPTSDTGISLLKVAVHEIGHVLGLPHTYRT 297
            G   AHA+  G     D HFD DE +T   P  D G  L  VAVHE+GH LGL H+   
Sbjct: 202 EGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHD-GNDLFLVAVHELGHALGLEHSNDP 260

Query: 298 GSIMQPNYIPQE-PAFELDWSDRKAIQKLYGS---------------------------- 328
            +IM P Y   E   F+L   D + IQK+YG                             
Sbjct: 261 TAIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKN 320

Query: 329 ----------------------CEGSFDTAFDWIRKERNQYGEVMVRFSTYFFRNSWYWL 366
                                 C+G+F+T               ++R   + F++ W+W 
Sbjct: 321 DRPKPPRPPTGRPSYPGAKPNICDGNFNTL-------------AILRREMFVFKDQWFW- 366

Query: 367 YENRNNRTRYGDPIQILTGWPGIPTHNIDA 396
              RNNR   G P+QI   W G+P  +IDA
Sbjct: 367 -RVRNNRVMDGYPMQITYFWRGLPP-SIDA 394


>gi|189217853 matrix metalloproteinase 2 isoform b [Homo sapiens]
          Length = 610

 Score = 95.1 bits (235), Expect = 2e-19
 Identities = 85/304 (27%), Positives = 131/304 (43%), Gaps = 36/304 (11%)

Query: 245 SGQEFAHAWRLGDIHFDDDEH--FTPPTSDTGISLLKVAVHEIGHVLGLPHTYRTGSIMQ 302
           +G+     W     ++DDD    F P   D G SL  VA HE GH +GL H+   G++M 
Sbjct: 316 AGRSDGKMWCATTANYDDDRKWGFCP---DQGYSLFLVAAHEFGHAMGLEHSQDPGALMA 372

Query: 303 PNYIPQEPAFELDWSDRKAIQKLYGSCE----GSFDTAF------DWIRKERNQYGEVMV 352
           P Y      F L   D K IQ+LYG+      G+  T        +  +++    G   +
Sbjct: 373 PIY-TYTKNFRLSQDDIKGIQELYGASPDIDLGTGPTPTLGPVTPEICKQDIVFDGIAQI 431

Query: 353 RFSTYFFRNSWYWLYENRNNRTRYGDPIQILTGWPGIPTHNIDAFVHIWTWKRDERYFFQ 412
           R   +FF++ + W       R +   P+ + T WP +P   IDA       + ++  FF 
Sbjct: 432 RGEIFFFKDRFIW--RTVTPRDKPMGPLLVATFWPELP-EKIDAVYE--APQEEKAVFFA 486

Query: 413 GNQYWRYDSDKDQALTEDEQGKSYPK-LISEGFPGIPSPLDTAFYDRRQKLIYFFKESLV 471
           GN+YW Y +   +        + YPK L S G P     +D AF   + K  Y F     
Sbjct: 487 GNEYWIYSASTLE--------RGYPKPLTSLGLPPDVQRVDAAFNWSKNKKTYIFAGDKF 538

Query: 472 FAFDVNRNRVLNSYPKRITEVFPAVIPQNHPFRNIDSAYYSYAYNSIFFFKGNAYWKVVN 531
           + ++  + ++   +PK I + + A IP      N+D+          +FFKG  Y K+ N
Sbjct: 539 WRYNEVKKKMDPGFPKLIADAWNA-IPD-----NLDAVVDLQGGGHSYFFKGAYYLKLEN 592

Query: 532 DKDK 535
              K
Sbjct: 593 QSLK 596



 Score = 68.9 bits (167), Expect = 1e-11
 Identities = 57/197 (28%), Positives = 80/197 (40%), Gaps = 48/197 (24%)

Query: 76  PPETPKGAALAEAVRRFQRANALPASGELDAATLAAMNRPRCGVPDMRPPPPSAPPSPPG 135
           P E+     L + +++ Q+   LP +G+LD  T+  M +PRCG PD+             
Sbjct: 11  PKESCNLFVLKDTLKKMQKFFGLPQTGDLDQNTIETMRKPRCGNPDV------------- 57

Query: 136 PPPRARSRRSPRAPLSLSRRGWQPRGYPDGGAAQAFSKRTLSWRLLGEALSSQLSVADQR 195
               A     PR P                     + K  +++R++G          D  
Sbjct: 58  ----ANYNFFPRKP--------------------KWDKNQITYRIIGYTPDLDPETVDDA 93

Query: 196 RIVALAFRMWSEVTPLDFREDLAAPGAAVDIKLGFGRGRHLGCPRAFDGSGQEFAHAWRL 255
              A AF++WS+VTPL F           DI + FGR  H G    FDG     AHA+  
Sbjct: 94  --FARAFQVWSDVTPLRFSR---IHDGEADIMINFGRWEH-GDGYPFDGKDGLLAHAFAP 147

Query: 256 -----GDIHFDDDEHFT 267
                GD HFDDDE +T
Sbjct: 148 GTGVGGDSHFDDDELWT 164


>gi|11342666 matrix metalloproteinase 2 isoform a preproprotein
           [Homo sapiens]
          Length = 660

 Score = 95.1 bits (235), Expect = 2e-19
 Identities = 85/304 (27%), Positives = 131/304 (43%), Gaps = 36/304 (11%)

Query: 245 SGQEFAHAWRLGDIHFDDDEH--FTPPTSDTGISLLKVAVHEIGHVLGLPHTYRTGSIMQ 302
           +G+     W     ++DDD    F P   D G SL  VA HE GH +GL H+   G++M 
Sbjct: 366 AGRSDGKMWCATTANYDDDRKWGFCP---DQGYSLFLVAAHEFGHAMGLEHSQDPGALMA 422

Query: 303 PNYIPQEPAFELDWSDRKAIQKLYGSCE----GSFDTAF------DWIRKERNQYGEVMV 352
           P Y      F L   D K IQ+LYG+      G+  T        +  +++    G   +
Sbjct: 423 PIY-TYTKNFRLSQDDIKGIQELYGASPDIDLGTGPTPTLGPVTPEICKQDIVFDGIAQI 481

Query: 353 RFSTYFFRNSWYWLYENRNNRTRYGDPIQILTGWPGIPTHNIDAFVHIWTWKRDERYFFQ 412
           R   +FF++ + W       R +   P+ + T WP +P   IDA       + ++  FF 
Sbjct: 482 RGEIFFFKDRFIW--RTVTPRDKPMGPLLVATFWPELP-EKIDAVYE--APQEEKAVFFA 536

Query: 413 GNQYWRYDSDKDQALTEDEQGKSYPK-LISEGFPGIPSPLDTAFYDRRQKLIYFFKESLV 471
           GN+YW Y +   +        + YPK L S G P     +D AF   + K  Y F     
Sbjct: 537 GNEYWIYSASTLE--------RGYPKPLTSLGLPPDVQRVDAAFNWSKNKKTYIFAGDKF 588

Query: 472 FAFDVNRNRVLNSYPKRITEVFPAVIPQNHPFRNIDSAYYSYAYNSIFFFKGNAYWKVVN 531
           + ++  + ++   +PK I + + A IP      N+D+          +FFKG  Y K+ N
Sbjct: 589 WRYNEVKKKMDPGFPKLIADAWNA-IPD-----NLDAVVDLQGGGHSYFFKGAYYLKLEN 642

Query: 532 DKDK 535
              K
Sbjct: 643 QSLK 646



 Score = 68.9 bits (167), Expect = 1e-11
 Identities = 57/197 (28%), Positives = 80/197 (40%), Gaps = 48/197 (24%)

Query: 76  PPETPKGAALAEAVRRFQRANALPASGELDAATLAAMNRPRCGVPDMRPPPPSAPPSPPG 135
           P E+     L + +++ Q+   LP +G+LD  T+  M +PRCG PD+             
Sbjct: 61  PKESCNLFVLKDTLKKMQKFFGLPQTGDLDQNTIETMRKPRCGNPDV------------- 107

Query: 136 PPPRARSRRSPRAPLSLSRRGWQPRGYPDGGAAQAFSKRTLSWRLLGEALSSQLSVADQR 195
               A     PR P                     + K  +++R++G          D  
Sbjct: 108 ----ANYNFFPRKP--------------------KWDKNQITYRIIGYTPDLDPETVDDA 143

Query: 196 RIVALAFRMWSEVTPLDFREDLAAPGAAVDIKLGFGRGRHLGCPRAFDGSGQEFAHAWRL 255
              A AF++WS+VTPL F           DI + FGR  H G    FDG     AHA+  
Sbjct: 144 --FARAFQVWSDVTPLRFSR---IHDGEADIMINFGRWEH-GDGYPFDGKDGLLAHAFAP 197

Query: 256 -----GDIHFDDDEHFT 267
                GD HFDDDE +T
Sbjct: 198 GTGVGGDSHFDDDELWT 214


>gi|73808266 matrix metalloproteinase 26 preproprotein [Homo
           sapiens]
          Length = 261

 Score = 88.6 bits (218), Expect = 1e-17
 Identities = 66/180 (36%), Positives = 89/180 (49%), Gaps = 22/180 (12%)

Query: 161 GYPDGGAAQA------FSKRTLSWRLLGEALSSQLSVADQRRIVALAFRMWSEVTPLDFR 214
           G PDG           ++K TL++R++      + S       +  A  +WS VTPL F+
Sbjct: 83  GVPDGSDTSISPGRCKWNKHTLTYRIINYPHDMKPSAVKDS--IYNAVSIWSNVTPLIFQ 140

Query: 215 EDLAAPGAAVDIKLGFGRGRHL-GCPRAFDGSGQEFAHAW-----RLGDIHFDDDEHFTP 268
           +         DIK+ F +  H  G P  FDG G    HA+       G +HFD +EH++ 
Sbjct: 141 Q---VQNGDADIKVSFWQWAHEDGWP--FDGPGGILGHAFLPNSGNPGVVHFDKNEHWS- 194

Query: 269 PTSDTGISLLKVAVHEIGHVLGLPHTYRTGSIMQPNYIPQEP-AFELDWSDRKAIQKLYG 327
             SDTG +L  VA HEIGH LGL H+    SIM P Y   +P  F+L   D + IQ LYG
Sbjct: 195 -ASDTGYNLFLVATHEIGHSLGLQHSGNQSSIMYPTYWYHDPRTFQLSADDIQRIQHLYG 253


>gi|5902004 matrix metalloproteinase 23B precursor [Homo sapiens]
          Length = 390

 Score = 80.9 bits (198), Expect = 3e-15
 Identities = 76/229 (33%), Positives = 103/229 (44%), Gaps = 35/229 (15%)

Query: 128 SAPPSPPGPPPRARSRRSPRAPLSLSRRGWQPRGYPDGGAAQAFSKRTLSWRLLGEALSS 187
           SA P    P P A  RR  R  L+ +R  W                  L++R+L     +
Sbjct: 61  SAVPPTRVPGPLAPRRR--RYTLTPARLRWD--------------HFNLTYRILSFP-RN 103

Query: 188 QLSVADQRRIVALAFRMWSEVTPLDFREDLAAPGAAVDIKLGFGRGRHLGC-----PRAF 242
            LS  + RR +A AFRMWS+V+P  FRE   AP    D+++GF    H  C        F
Sbjct: 104 LLSPRETRRALAAAFRMWSDVSPFSFRE--VAPEQPSDLRIGFYPINHTDCLVSALHHCF 161

Query: 243 DGSGQEFAHAW--RLGDIHFDDDEHF----TPPTSDTGI---SLLKVAVHEIGHVLGLPH 293
           DG   E AHA+    G IHFDD E++    T  +   G+    L+ VA HEIGH LGL H
Sbjct: 162 DGPTGELAHAFFPPHGGIHFDDSEYWVLGPTRYSWKKGVWLTDLVHVAAHEIGHALGLMH 221

Query: 294 TYRTGSIMQPNYIPQEPAFELDWSDRKAIQKLYGSCEGSFDTAFDWIRK 342
           +    ++M  N         L   +   + +LYG  +  F  A  W R+
Sbjct: 222 SQHGRALMHLN-ATLRGWKALSQDELWGLHRLYGCLDRLFVCA-SWARR 268


>gi|74272287 matrix metalloproteinase 9 preproprotein [Homo sapiens]
          Length = 707

 Score = 68.9 bits (167), Expect = 1e-11
 Identities = 81/275 (29%), Positives = 104/275 (37%), Gaps = 83/275 (30%)

Query: 5   SIFRPTLLL-----CWLAAPWPTQPESLFHSRDRSDLEPSPLRQAKPIADLHAAQRFLSR 59
           S+++P +L+     C  AAP   Q   +        L P  LR    + D   A+ +L R
Sbjct: 2   SLWQPLVLVLLVLGCCFAAPRQRQSTLV--------LFPGDLRTN--LTDRQLAEEYLYR 51

Query: 60  YGWSGVWAAWGPSPEGPPETPKGAALAEAVRRFQRANALPASGELDAATLAAMNRPRCGV 119
           YG++ V    G S           +L  A+   Q+  +LP +GELD+ATL AM  PRCGV
Sbjct: 52  YGYTRVAEMRGESK----------SLGPALLLLQKQLSLPETGELDSATLKAMRTPRCGV 101

Query: 120 PDMRPPPPSAPPSPPGPPPRARSRRSPRAPLSLSRRGWQPRGYPDGGAAQAFSKRTLSWR 179
           PD+                                           G  Q F +  L W 
Sbjct: 102 PDL-------------------------------------------GRFQTF-EGDLKWH 117

Query: 180 LLGEALSSQLSVADQRRIV-----ALAFRMWSEVTPLDFREDLAAPGAAVDIKLGFGRGR 234
                   Q    D  R V     A AF +WS VTPL F    +      DI + FG   
Sbjct: 118 HHNITYWIQNYSEDLPRAVIDDAFARAFALWSAVTPLTFTRVYSRD---ADIVIQFGVAE 174

Query: 235 HLGCPRAFDGSGQEFAHAWR-----LGDIHFDDDE 264
           H G    FDG     AHA+       GD HFDDDE
Sbjct: 175 H-GDGYPFDGKDGLLAHAFPPGPGIQGDAHFDDDE 208



 Score = 42.7 bits (99), Expect = 9e-04
 Identities = 31/85 (36%), Positives = 39/85 (45%), Gaps = 8/85 (9%)

Query: 246 GQEFAHAWRLGDIHFDDDEH--FTPPTSDTGISLLKVAVHEIGHVLGLPHTYRTGSIMQP 303
           G+     W     +FD D+   F P   D G SL  VA HE GH LGL H+    ++M P
Sbjct: 365 GRGDGRLWCATTSNFDSDKKWGFCP---DQGYSLFLVAAHEFGHALGLDHSSVPEALMYP 421

Query: 304 NY-IPQEPAFELDWSDRKAIQKLYG 327
            Y   + P    D  D   I+ LYG
Sbjct: 422 MYRFTEGPPLHKD--DVNGIRHLYG 444



 Score = 40.0 bits (92), Expect = 0.006
 Identities = 20/69 (28%), Positives = 36/69 (52%), Gaps = 7/69 (10%)

Query: 406 DERYFFQGNQYWRYDSDKDQALTEDEQGKSYPKLISEGFPGIPSPLDTAFYDRRQKLIYF 465
           ++ Y F+  +YWR+   +        QG   P LI++ +P +P  LD+ F +R  K ++F
Sbjct: 529 NQLYLFKDGKYWRFSEGRGSR----PQG---PFLIADKWPALPRKLDSVFEERLSKKLFF 581

Query: 466 FKESLVFAF 474
           F    V+ +
Sbjct: 582 FSGRQVWVY 590


>gi|239750339 PREDICTED: hypothetical protein XP_002347374 [Homo
           sapiens]
          Length = 183

 Score = 64.3 bits (155), Expect = 3e-10
 Identities = 59/193 (30%), Positives = 83/193 (43%), Gaps = 47/193 (24%)

Query: 56  FLSRYGWSGVWAAWGPSPEGPPETPKGAALAEAVRRFQRANALPASGELDAATLAAMNRP 115
           +LS+YG+          P       K   + EA+R FQ A+ LP SG+LD AT A M +P
Sbjct: 31  YLSQYGYL-------QKPLEGSNNFKPEDITEALRAFQEASELPVSGQLDDATRARMRQP 83

Query: 116 RCGVPDMRPPPPSAPPSPPGPPPRARSRRSPRAPLSLSRRGWQPRGYPDGGAAQAFSKRT 175
           RCG+ D               P   ++ +     L L R  W+              K+ 
Sbjct: 84  RCGLED---------------PFNQKTLKY----LLLGR--WR--------------KKH 108

Query: 176 LSWRLLGEALSSQLSVADQRRIVALAFRMWSEVTPLDFREDLAAPGAAVDIKLGFGRGRH 235
           L++R+L   L S L     R  +  AF+ WS V PL F+E       A DI+L F   + 
Sbjct: 109 LTFRILN--LPSTLPPHTARAALRQAFQDWSNVAPLTFQE---VQAGAADIRLSFHGRQS 163

Query: 236 LGCPRAFDGSGQE 248
             C   FDG G++
Sbjct: 164 SYCSNTFDGPGRQ 176


>gi|73808271 matrix metalloproteinase 28 isoform 3 [Homo sapiens]
          Length = 130

 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 29/69 (42%), Positives = 37/69 (53%), Gaps = 9/69 (13%)

Query: 53  AQRFLSRYGWSGVWAAWGPSPEGPPETPKGAALAEAVRRFQRANALPASGELDAATLAAM 112
           A+ FL +YG+           E  P+ P     ++A+R FQ  + LP SG LD ATL  M
Sbjct: 36  AEAFLEKYGYLN---------EQVPKAPTSTRFSDAIRAFQWVSQLPVSGVLDRATLRQM 86

Query: 113 NRPRCGVPD 121
            RPRCGV D
Sbjct: 87  TRPRCGVTD 95


>gi|88853069 vitronectin precursor [Homo sapiens]
          Length = 478

 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 42/119 (35%), Positives = 56/119 (47%), Gaps = 20/119 (16%)

Query: 355 STYFFRNSWYWLYENRNNRTRYGDPIQILTGWPGIPTHNIDAFVHIWTWKRDERYFFQGN 414
           S + FR  +   YE      R G P  I   W GI      AF  I    + + Y F+G+
Sbjct: 171 SLFAFRGQY--CYELDEKAVRPGYPKLIRDVW-GIEGPIDAAFTRINC--QGKTYLFKGS 225

Query: 415 QYWRYDSDKDQALTEDEQGKSYPKLISEGFPGIPSPLDTAF------YDRRQKLIYFFK 467
           QYWR++   D  L  D     YP+ IS+GF GIP  +D A       Y  R++ +YFFK
Sbjct: 226 QYWRFE---DGVLDPD-----YPRNISDGFDGIPDNVDAALALPAHSYSGRER-VYFFK 275



 Score = 47.0 bits (110), Expect = 5e-05
 Identities = 41/119 (34%), Positives = 57/119 (47%), Gaps = 18/119 (15%)

Query: 320 KAIQKLYGSCEGSFDTAFDWIRKERNQYGEVMVRFSTYFFRNSWYWLYENRNNRTRYGDP 379
           K I+ ++G  EG  D AF  I    N  G+      TY F+ S YW +E+      Y  P
Sbjct: 194 KLIRDVWG-IEGPIDAAFTRI----NCQGK------TYLFKGSQYWRFEDGVLDPDY--P 240

Query: 380 IQILTGWPGIPTHNIDAFVHIWTWK---RDERYFFQGNQYWRYDSDKDQALTEDEQGKS 435
             I  G+ GIP  N+DA + +       R+  YFF+G QYW Y   + Q   E+ +G S
Sbjct: 241 RNISDGFDGIPD-NVDAALALPAHSYSGRERVYFFKGKQYWEYQF-QHQPSQEECEGSS 297



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 41/136 (30%), Positives = 59/136 (43%), Gaps = 18/136 (13%)

Query: 395 DAFVHIWTWKRDERYFFQGNQYWRYDSDKDQALTEDEQGKSYPKLISEGFPGIPSPLDTA 454
           DAF  +   K    + F+G   +  D        E      YPKLI + + GI  P+D A
Sbjct: 162 DAFTDL---KNGSLFAFRGQYCYELD--------EKAVRPGYPKLIRDVW-GIEGPIDAA 209

Query: 455 FYDRR-QKLIYFFKESLVFAFDVNRNRVLN-SYPKRITEVFPAVIPQNHPFRNIDSAYYS 512
           F     Q   Y FK S  + F+   + VL+  YP+ I++ F   IP N        A+  
Sbjct: 210 FTRINCQGKTYLFKGSQYWRFE---DGVLDPDYPRNISDGFDG-IPDNVDAALALPAHSY 265

Query: 513 YAYNSIFFFKGNAYWK 528
                ++FFKG  YW+
Sbjct: 266 SGRERVYFFKGKQYWE 281


>gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo
           sapiens]
          Length = 1124

 Score = 43.9 bits (102), Expect = 4e-04
 Identities = 45/149 (30%), Positives = 62/149 (41%), Gaps = 22/149 (14%)

Query: 25  ESLFHSRDRSDLEPSPLRQAKPIA----------DLHAAQRFLSRYGWSGVWAAWGPSPE 74
           +S+  + + S  EPSP  + +P A           L ++   LS    SG  A   P   
Sbjct: 207 KSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAP 266

Query: 75  GPPETPKGAALAEAVRRFQ----RANALPASGELDAATLAAMNRPRCGVPDMRPP----- 125
             P  PK   L +A+R  Q    R +A PA G L ++ LA  +        + PP     
Sbjct: 267 AHPSQPKPKGL-QALRPPQVTPPRKDAAPALGPLSSSPLATPSPSGTKARPVPPPDNAAT 325

Query: 126 --PPSAPPSPPGPPPRARSRRSPRAPLSL 152
             P + PPSPP   P   +  SP AP SL
Sbjct: 326 PLPATLPPSPPLATPLPLAPPSPSAPPSL 354



 Score = 36.2 bits (82), Expect = 0.083
 Identities = 42/145 (28%), Positives = 54/145 (37%), Gaps = 20/145 (13%)

Query: 9   PTLLLCWLAAPWPTQPESLFHSRDRSDLEP--SPLRQAKPIADLHAAQRFLSRYGWSGVW 66
           P L L  L AP P+ P S         L P  +P  QA     +H  Q   S      V 
Sbjct: 623 PXLALPPLQAP-PSPPAS-------PPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQ 674

Query: 67  AAWGPSPEGPPETPKGAALAEA-----VRRFQRANALPASGELDAATLAAMNRPRCGVPD 121
           A + P P  PP +P     ++A         Q   + PAS  +  +       P    P 
Sbjct: 675 APFSP-PASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAP----PP 729

Query: 122 MRPPPPSAPPSPPGPPPRARSRRSP 146
           +  PP   PPSPP  PP + S   P
Sbjct: 730 LAAPPLQVPPSPPASPPMSPSATPP 754



 Score = 34.3 bits (77), Expect = 0.32
 Identities = 30/87 (34%), Positives = 42/87 (48%), Gaps = 6/87 (6%)

Query: 71  PSP--EGPPETPKGAALAEAVRRFQRANALPASGELDAATLAAM-NRPRCGVPDMRPPPP 127
           PSP    PPETP  +++A    +   A A P    L +  L+ +   P    P +  PP 
Sbjct: 573 PSPLTTPPPETP--SSIATPPPQAPPALASPPLQGLPSPPLSPLATPPPQAPPXLALPPL 630

Query: 128 SAPPS-PPGPPPRARSRRSPRAPLSLS 153
            APPS P  PP    +  SP+AP +L+
Sbjct: 631 QAPPSPPASPPLSPLATPSPQAPNALA 657



 Score = 32.3 bits (72), Expect = 1.2
 Identities = 28/100 (28%), Positives = 38/100 (38%), Gaps = 18/100 (18%)

Query: 72  SPEGPPETPKGAALAE---------AVRRFQRANALPASGELDAA--------TLAAMNR 114
           +P  PP +P  + LA          AV   Q   + P S  + A            +   
Sbjct: 632 APPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATP 691

Query: 115 PRCGVPDMRPPPPSAPPSPPGPPPRARSRR-SPRAPLSLS 153
           P    P +  PP   PPSPP  PP + S    P+AP  L+
Sbjct: 692 PSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLA 731



 Score = 32.3 bits (72), Expect = 1.2
 Identities = 25/78 (32%), Positives = 28/78 (35%), Gaps = 4/78 (5%)

Query: 71  PSPEGPPE--TPKGAALAEAVRRFQRANALPASGELDAATLAAMNRPRCGVPDMRPPPPS 128
           P P+ PP   TP   AL      F        S  L  + LA    P    P +  P   
Sbjct: 784 PPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATP--PPQAPPVLAAPLLQ 841

Query: 129 APPSPPGPPPRARSRRSP 146
            PPSPP  P     RR P
Sbjct: 842 VPPSPPASPTLQAPRRPP 859



 Score = 30.8 bits (68), Expect = 3.5
 Identities = 32/104 (30%), Positives = 43/104 (41%), Gaps = 13/104 (12%)

Query: 78  ETPKGAALAEAVRRFQRANALPASGELDAATLAAMNRPRCGVPDMRPPPPSAPPSPPGPP 137
           E PK +AL+   RR   +   P +     A  +       G+P    P PSA P PP   
Sbjct: 149 EAPKRSALSAGARR-DTSGPTPGTPSPAMARRSRAAGTEVGLPR---PAPSARPRPPTEG 204

Query: 138 PR----ARSRRSPRAPLSLSRRGWQPRGYPDGGAAQAFSKRTLS 177
           PR    + S  S   P   +RR  +P     GG  Q  + R+LS
Sbjct: 205 PRKSVSSASEHSTTEPSPAARR--RPSA---GGGLQRPASRSLS 243



 Score = 30.0 bits (66), Expect = 5.9
 Identities = 28/91 (30%), Positives = 35/91 (38%), Gaps = 17/91 (18%)

Query: 71  PSPEGPPE----------TPKGAALAEAVRRFQRANALPASGELDAATLAAMNRPRCGVP 120
           PS + PP           T  G+   +A   F     L  S     A+L + +RP    P
Sbjct: 398 PSLQAPPSPLALSSLQATTSLGSPTLQATHSF-----LTMSPRQTQASLTSPSRPASTPP 452

Query: 121 DMRPPPPSAPPSPPGPPPRARSRRSPRAPLS 151
           D   PP  AP S P  PP   S     +PLS
Sbjct: 453 DS--PPLQAPLSLPASPPLQTSLSPAVSPLS 481


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.321    0.138    0.453 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,651,395
Number of Sequences: 37866
Number of extensions: 1499435
Number of successful extensions: 24654
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 355
Number of HSP's successfully gapped in prelim test: 637
Number of HSP's that attempted gapping in prelim test: 14740
Number of HSP's gapped (non-prelim): 6357
length of query: 569
length of database: 18,247,518
effective HSP length: 108
effective length of query: 461
effective length of database: 14,157,990
effective search space: 6526833390
effective search space used: 6526833390
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.