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Search of human proteins with 221316622
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|221316622 dystonin isoform 3 [Homo sapiens]
(5537 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|221316622 dystonin isoform 3 [Homo sapiens] 1.085e+04 0.0
gi|221316618 dystonin isoform 2 [Homo sapiens] 1.085e+04 0.0
gi|221316624 dystonin isoform 4 [Homo sapiens] 1.083e+04 0.0
gi|34577047 dystonin isoform 1 [Homo sapiens] 1.071e+04 0.0
gi|34577049 dystonin isoform 1eA precursor [Homo sapiens] 9997 0.0
gi|33188445 microfilament and actin filament cross-linker protei... 5941 0.0
gi|33188443 microfilament and actin filament cross-linker protei... 4237 0.0
gi|20357504 dystonin isoform 1eB precursor [Homo sapiens] 2291 0.0
gi|4502443 dystonin isoform 1e precursor [Homo sapiens] 2122 0.0
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 861 0.0
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 861 0.0
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 861 0.0
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 861 0.0
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 861 0.0
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 861 0.0
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 861 0.0
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 861 0.0
gi|169218211 PREDICTED: similar to plectin 1, partial [Homo sapi... 667 0.0
gi|58530840 desmoplakin isoform I [Homo sapiens] 609 e-173
gi|58530842 desmoplakin isoform II [Homo sapiens] 577 e-164
gi|154277116 spectrin repeat containing, nuclear envelope 1 isof... 372 e-102
gi|5032281 dystrophin Dp427c isoform [Homo sapiens] 325 1e-87
gi|5032315 dystrophin Dp427p2 isoform [Homo sapiens] 325 1e-87
gi|5032287 dystrophin Dp427p1 isoform [Homo sapiens] 325 1e-87
gi|5032285 dystrophin Dp427l isoform [Homo sapiens] 325 1e-87
gi|5032283 dystrophin Dp427m isoform [Homo sapiens] 325 1e-87
gi|23097308 spectrin repeat containing, nuclear envelope 1 isofo... 318 9e-86
gi|5902122 spectrin, beta, non-erythrocytic 2 [Homo sapiens] 315 1e-84
gi|112382252 spectrin, beta, non-erythrocytic 1 isoform 2 [Homo ... 311 9e-84
gi|45439327 periplakin [Homo sapiens] 311 9e-84
>gi|221316622 dystonin isoform 3 [Homo sapiens]
Length = 5537
Score = 1.085e+04 bits (28150), Expect = 0.0
Identities = 5537/5537 (100%), Positives = 5537/5537 (100%)
Query: 1 MSSGNASYRCSMSSSADFSDEDDFSQKSGSASPAPGDTLPWNLPKHERSKRKIQGGSVLD 60
MSSGNASYRCSMSSSADFSDEDDFSQKSGSASPAPGDTLPWNLPKHERSKRKIQGGSVLD
Sbjct: 1 MSSGNASYRCSMSSSADFSDEDDFSQKSGSASPAPGDTLPWNLPKHERSKRKIQGGSVLD 60
Query: 61 PAERAVLRIADERDKVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEVLSGDT 120
PAERAVLRIADERDKVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEVLSGDT
Sbjct: 61 PAERAVLRIADERDKVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEVLSGDT 120
Query: 121 LPREKGRMRFHRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQIS 180
LPREKGRMRFHRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQIS
Sbjct: 121 LPREKGRMRFHRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQIS 180
Query: 181 DIHVTGESEDMSAKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLIDM 240
DIHVTGESEDMSAKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLIDM
Sbjct: 181 DIHVTGESEDMSAKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLIDM 240
Query: 241 NTVAVQSNLANLEHAFYVAEKIGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAFPKVPEG 300
NTVAVQSNLANLEHAFYVAEKIGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAFPKVPEG
Sbjct: 241 NTVAVQSNLANLEHAFYVAEKIGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAFPKVPEG 300
Query: 301 GEGIGANDVEVKWIEYQNMVNYLIQWIRHHVTTMSERTFPNNPVELKALYNQYLQFKETE 360
GEGIGANDVEVKWIEYQNMVNYLIQWIRHHVTTMSERTFPNNPVELKALYNQYLQFKETE
Sbjct: 301 GEGIGANDVEVKWIEYQNMVNYLIQWIRHHVTTMSERTFPNNPVELKALYNQYLQFKETE 360
Query: 361 IPPKETEKSKIKRLYKLLEIWIEFGRIKLLQGYHPNDIEKEWGKLIIAMLEREKALRPEV 420
IPPKETEKSKIKRLYKLLEIWIEFGRIKLLQGYHPNDIEKEWGKLIIAMLEREKALRPEV
Sbjct: 361 IPPKETEKSKIKRLYKLLEIWIEFGRIKLLQGYHPNDIEKEWGKLIIAMLEREKALRPEV 420
Query: 421 ERLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENL 480
ERLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENL
Sbjct: 421 ERLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENL 480
Query: 481 LRQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMIS 540
LRQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMIS
Sbjct: 481 LRQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMIS 540
Query: 541 GITQSLNSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFP 600
GITQSLNSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFP
Sbjct: 541 GITQSLNSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFP 600
Query: 601 SGLVPNFSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQV 660
SGLVPNFSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQV
Sbjct: 601 SGLVPNFSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQV 660
Query: 661 QLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRL 720
QLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRL
Sbjct: 661 QLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRL 720
Query: 721 ESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDY 780
ESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDY
Sbjct: 721 ESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDY 780
Query: 781 HAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQH 840
HAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQH
Sbjct: 781 HAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQH 840
Query: 841 IKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQY 900
IKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQY
Sbjct: 841 IKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQY 900
Query: 901 KSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRA 960
KSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRA
Sbjct: 901 KSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRA 960
Query: 961 KWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWH 1020
KWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWH
Sbjct: 961 KWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWH 1020
Query: 1021 YLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKE 1080
YLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKE
Sbjct: 1021 YLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKE 1080
Query: 1081 VNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLH 1140
VNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLH
Sbjct: 1081 VNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLH 1140
Query: 1141 ESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQV 1200
ESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQV
Sbjct: 1141 ESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQV 1200
Query: 1201 YSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRS 1260
YSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRS
Sbjct: 1201 YSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRS 1260
Query: 1261 EVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDN 1320
EVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDN
Sbjct: 1261 EVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDN 1320
Query: 1321 RLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSE 1380
RLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSE
Sbjct: 1321 RLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSE 1380
Query: 1381 IEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEF 1440
IEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEF
Sbjct: 1381 IEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEF 1440
Query: 1441 MDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTL 1500
MDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTL
Sbjct: 1441 MDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTL 1500
Query: 1501 KDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKT 1560
KDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKT
Sbjct: 1501 KDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKT 1560
Query: 1561 LQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGH 1620
LQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGH
Sbjct: 1561 LQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGH 1620
Query: 1621 QEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALI 1680
QEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALI
Sbjct: 1621 QEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALI 1680
Query: 1681 EQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWL 1740
EQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWL
Sbjct: 1681 EQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWL 1740
Query: 1741 SNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENL 1800
SNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENL
Sbjct: 1741 SNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENL 1800
Query: 1801 NQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYET 1860
NQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYET
Sbjct: 1801 NQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYET 1860
Query: 1861 ALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQ 1920
ALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQ
Sbjct: 1861 ALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQ 1920
Query: 1921 KSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFR 1980
KSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFR
Sbjct: 1921 KSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFR 1980
Query: 1981 SLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQL 2040
SLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQL
Sbjct: 1981 SLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQL 2040
Query: 2041 EETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVN 2100
EETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVN
Sbjct: 2041 EETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVN 2100
Query: 2101 ERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQD 2160
ERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQD
Sbjct: 2101 ERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQD 2160
Query: 2161 IAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKT 2220
IAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKT
Sbjct: 2161 IAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKT 2220
Query: 2221 KVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSL 2280
KVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSL
Sbjct: 2221 KVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSL 2280
Query: 2281 LKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKS 2340
LKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKS
Sbjct: 2281 LKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKS 2340
Query: 2341 WIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVT 2400
WIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVT
Sbjct: 2341 WIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVT 2400
Query: 2401 TPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIA 2460
TPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIA
Sbjct: 2401 TPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIA 2460
Query: 2461 ELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELK 2520
ELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELK
Sbjct: 2461 ELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELK 2520
Query: 2521 QNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNN 2580
QNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNN
Sbjct: 2521 QNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNN 2580
Query: 2581 LTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLT 2640
LTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLT
Sbjct: 2581 LTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLT 2640
Query: 2641 AAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLR 2700
AAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLR
Sbjct: 2641 AAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLR 2700
Query: 2701 SLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSAL 2760
SLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSAL
Sbjct: 2701 SLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSAL 2760
Query: 2761 VKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKK 2820
VKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKK
Sbjct: 2761 VKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKK 2820
Query: 2821 EEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQ 2880
EEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQ
Sbjct: 2821 EEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQ 2880
Query: 2881 LQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLD 2940
LQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLD
Sbjct: 2881 LQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLD 2940
Query: 2941 PAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMV 3000
PAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMV
Sbjct: 2941 PAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMV 3000
Query: 3001 TEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQT 3060
TEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQT
Sbjct: 3001 TEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQT 3060
Query: 3061 QQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFL 3120
QQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFL
Sbjct: 3061 QQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFL 3120
Query: 3121 ETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMA 3180
ETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMA
Sbjct: 3121 ETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMA 3180
Query: 3181 SNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEF 3240
SNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEF
Sbjct: 3181 SNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEF 3240
Query: 3241 YSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLG 3300
YSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLG
Sbjct: 3241 YSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLG 3300
Query: 3301 QGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLS 3360
QGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLS
Sbjct: 3301 QGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLS 3360
Query: 3361 WMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPA 3420
WMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPA
Sbjct: 3361 WMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPA 3420
Query: 3421 DKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVN 3480
DKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVN
Sbjct: 3421 DKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVN 3480
Query: 3481 CEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDF 3540
CEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDF
Sbjct: 3481 CEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDF 3540
Query: 3541 SQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGL 3600
SQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGL
Sbjct: 3541 SQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGL 3600
Query: 3601 WKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKL 3660
WKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKL
Sbjct: 3601 WKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKL 3660
Query: 3661 STDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELK 3720
STDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELK
Sbjct: 3661 STDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELK 3720
Query: 3721 KEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAA 3780
KEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAA
Sbjct: 3721 KEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAA 3780
Query: 3781 ILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIID 3840
ILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIID
Sbjct: 3781 ILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIID 3840
Query: 3841 DLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETY 3900
DLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETY
Sbjct: 3841 DLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETY 3900
Query: 3901 EELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLE 3960
EELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLE
Sbjct: 3901 EELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLE 3960
Query: 3961 LSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVE 4020
LSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVE
Sbjct: 3961 LSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVE 4020
Query: 4021 RLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAK 4080
RLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAK
Sbjct: 4021 RLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAK 4080
Query: 4081 AVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLED 4140
AVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLED
Sbjct: 4081 AVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLED 4140
Query: 4141 PGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNS 4200
PGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNS
Sbjct: 4141 PGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNS 4200
Query: 4201 AWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQ 4260
AWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQ
Sbjct: 4201 AWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQ 4260
Query: 4261 IEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERII 4320
IEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERII
Sbjct: 4261 IEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERII 4320
Query: 4321 NRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQND 4380
NRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQND
Sbjct: 4321 NRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQND 4380
Query: 4381 VLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALR 4440
VLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALR
Sbjct: 4381 VLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALR 4440
Query: 4441 QAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSL 4500
QAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSL
Sbjct: 4441 QAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSL 4500
Query: 4501 MQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQD 4560
MQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQD
Sbjct: 4501 MQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQD 4560
Query: 4561 FINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFS 4620
FINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFS
Sbjct: 4561 FINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFS 4620
Query: 4621 QKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKS 4680
QKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKS
Sbjct: 4621 QKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKS 4680
Query: 4681 LDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDD 4740
LDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDD
Sbjct: 4681 LDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDD 4740
Query: 4741 MLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGD 4800
MLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGD
Sbjct: 4741 MLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGD 4800
Query: 4801 IDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETV 4860
IDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETV
Sbjct: 4801 IDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETV 4860
Query: 4861 CALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHK 4920
CALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHK
Sbjct: 4861 CALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHK 4920
Query: 4921 EFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRL 4980
EFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRL
Sbjct: 4921 EFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRL 4980
Query: 4981 ASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRK 5040
ASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRK
Sbjct: 4981 ASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRK 5040
Query: 5041 QPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETKNPRVN 5100
QPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETKNPRVN
Sbjct: 5041 QPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETKNPRVN 5100
Query: 5101 LLVSKWQQVWLLALERRRKLNDALDRLEELREFANFDFDIWRKKYMRWMNHKKSRVMDFF 5160
LLVSKWQQVWLLALERRRKLNDALDRLEELREFANFDFDIWRKKYMRWMNHKKSRVMDFF
Sbjct: 5101 LLVSKWQQVWLLALERRRKLNDALDRLEELREFANFDFDIWRKKYMRWMNHKKSRVMDFF 5160
Query: 5161 RRIDKDQDGKITRQEFIDGILSSKFPTSRLEMSAVADIFDRDGDGYIDYYEFVAALHPNK 5220
RRIDKDQDGKITRQEFIDGILSSKFPTSRLEMSAVADIFDRDGDGYIDYYEFVAALHPNK
Sbjct: 5161 RRIDKDQDGKITRQEFIDGILSSKFPTSRLEMSAVADIFDRDGDGYIDYYEFVAALHPNK 5220
Query: 5221 DAYKPITDADKIEDEVTRQVAKCKCAKRFQVEQIGDNKYRFFLGNQFGDSQQLRLVRILR 5280
DAYKPITDADKIEDEVTRQVAKCKCAKRFQVEQIGDNKYRFFLGNQFGDSQQLRLVRILR
Sbjct: 5221 DAYKPITDADKIEDEVTRQVAKCKCAKRFQVEQIGDNKYRFFLGNQFGDSQQLRLVRILR 5280
Query: 5281 STVMVRVGGGWMALDEFLVKNDPCRAKGRTNMELREKFILADGASQGMAAFRPRGRRSRP 5340
STVMVRVGGGWMALDEFLVKNDPCRAKGRTNMELREKFILADGASQGMAAFRPRGRRSRP
Sbjct: 5281 STVMVRVGGGWMALDEFLVKNDPCRAKGRTNMELREKFILADGASQGMAAFRPRGRRSRP 5340
Query: 5341 SSRGASPNRSTSVSSQAAQAASPQVPATTTPKILHPLTRNYGKPWLTNSKMSTPCKAAEC 5400
SSRGASPNRSTSVSSQAAQAASPQVPATTTPKILHPLTRNYGKPWLTNSKMSTPCKAAEC
Sbjct: 5341 SSRGASPNRSTSVSSQAAQAASPQVPATTTPKILHPLTRNYGKPWLTNSKMSTPCKAAEC 5400
Query: 5401 SDFPVPSAEGTPIQGSKLRLPGYLSGKGFHSGEDSGLITTAAARVRTQFADSKKTPSRPG 5460
SDFPVPSAEGTPIQGSKLRLPGYLSGKGFHSGEDSGLITTAAARVRTQFADSKKTPSRPG
Sbjct: 5401 SDFPVPSAEGTPIQGSKLRLPGYLSGKGFHSGEDSGLITTAAARVRTQFADSKKTPSRPG 5460
Query: 5461 SRAGSKAGSRASSRRGSDASDFDISEIQSVCSDVETVPQTHRPTPRAGSRPSTAKPSKIP 5520
SRAGSKAGSRASSRRGSDASDFDISEIQSVCSDVETVPQTHRPTPRAGSRPSTAKPSKIP
Sbjct: 5461 SRAGSKAGSRASSRRGSDASDFDISEIQSVCSDVETVPQTHRPTPRAGSRPSTAKPSKIP 5520
Query: 5521 TPQRKSPASKLDKSSKR 5537
TPQRKSPASKLDKSSKR
Sbjct: 5521 TPQRKSPASKLDKSSKR 5537
>gi|221316618 dystonin isoform 2 [Homo sapiens]
Length = 5675
Score = 1.085e+04 bits (28145), Expect = 0.0
Identities = 5536/5536 (100%), Positives = 5536/5536 (100%)
Query: 2 SSGNASYRCSMSSSADFSDEDDFSQKSGSASPAPGDTLPWNLPKHERSKRKIQGGSVLDP 61
SSGNASYRCSMSSSADFSDEDDFSQKSGSASPAPGDTLPWNLPKHERSKRKIQGGSVLDP
Sbjct: 140 SSGNASYRCSMSSSADFSDEDDFSQKSGSASPAPGDTLPWNLPKHERSKRKIQGGSVLDP 199
Query: 62 AERAVLRIADERDKVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEVLSGDTL 121
AERAVLRIADERDKVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEVLSGDTL
Sbjct: 200 AERAVLRIADERDKVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEVLSGDTL 259
Query: 122 PREKGRMRFHRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISD 181
PREKGRMRFHRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISD
Sbjct: 260 PREKGRMRFHRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISD 319
Query: 182 IHVTGESEDMSAKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLIDMN 241
IHVTGESEDMSAKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLIDMN
Sbjct: 320 IHVTGESEDMSAKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLIDMN 379
Query: 242 TVAVQSNLANLEHAFYVAEKIGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAFPKVPEGG 301
TVAVQSNLANLEHAFYVAEKIGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAFPKVPEGG
Sbjct: 380 TVAVQSNLANLEHAFYVAEKIGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAFPKVPEGG 439
Query: 302 EGIGANDVEVKWIEYQNMVNYLIQWIRHHVTTMSERTFPNNPVELKALYNQYLQFKETEI 361
EGIGANDVEVKWIEYQNMVNYLIQWIRHHVTTMSERTFPNNPVELKALYNQYLQFKETEI
Sbjct: 440 EGIGANDVEVKWIEYQNMVNYLIQWIRHHVTTMSERTFPNNPVELKALYNQYLQFKETEI 499
Query: 362 PPKETEKSKIKRLYKLLEIWIEFGRIKLLQGYHPNDIEKEWGKLIIAMLEREKALRPEVE 421
PPKETEKSKIKRLYKLLEIWIEFGRIKLLQGYHPNDIEKEWGKLIIAMLEREKALRPEVE
Sbjct: 500 PPKETEKSKIKRLYKLLEIWIEFGRIKLLQGYHPNDIEKEWGKLIIAMLEREKALRPEVE 559
Query: 422 RLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLL 481
RLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLL
Sbjct: 560 RLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLL 619
Query: 482 RQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISG 541
RQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISG
Sbjct: 620 RQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISG 679
Query: 542 ITQSLNSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPS 601
ITQSLNSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPS
Sbjct: 680 ITQSLNSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPS 739
Query: 602 GLVPNFSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQ 661
GLVPNFSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQ
Sbjct: 740 GLVPNFSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQ 799
Query: 662 LDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLE 721
LDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLE
Sbjct: 800 LDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLE 859
Query: 722 SQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYH 781
SQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYH
Sbjct: 860 SQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYH 919
Query: 782 AELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHI 841
AELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHI
Sbjct: 920 AELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHI 979
Query: 842 KENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYK 901
KENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYK
Sbjct: 980 KENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYK 1039
Query: 902 STIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAK 961
STIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAK
Sbjct: 1040 STIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAK 1099
Query: 962 WKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHY 1021
WKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHY
Sbjct: 1100 WKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHY 1159
Query: 1022 LINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEV 1081
LINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEV
Sbjct: 1160 LINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEV 1219
Query: 1082 NVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHE 1141
NVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHE
Sbjct: 1220 NVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHE 1279
Query: 1142 SVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVY 1201
SVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVY
Sbjct: 1280 SVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVY 1339
Query: 1202 SMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSE 1261
SMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSE
Sbjct: 1340 SMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSE 1399
Query: 1262 VDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNR 1321
VDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNR
Sbjct: 1400 VDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNR 1459
Query: 1322 LRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEI 1381
LRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEI
Sbjct: 1460 LRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEI 1519
Query: 1382 EMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFM 1441
EMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFM
Sbjct: 1520 EMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFM 1579
Query: 1442 DLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLK 1501
DLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLK
Sbjct: 1580 DLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLK 1639
Query: 1502 DAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTL 1561
DAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTL
Sbjct: 1640 DAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTL 1699
Query: 1562 QESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQ 1621
QESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQ
Sbjct: 1700 QESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQ 1759
Query: 1622 EAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIE 1681
EAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIE
Sbjct: 1760 EAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIE 1819
Query: 1682 QKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLS 1741
QKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLS
Sbjct: 1820 QKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLS 1879
Query: 1742 NVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLN 1801
NVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLN
Sbjct: 1880 NVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLN 1939
Query: 1802 QQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETA 1861
QQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETA
Sbjct: 1940 QQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETA 1999
Query: 1862 LAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQK 1921
LAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQK
Sbjct: 2000 LAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQK 2059
Query: 1922 SFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRS 1981
SFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRS
Sbjct: 2060 SFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRS 2119
Query: 1982 LYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLE 2041
LYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLE
Sbjct: 2120 LYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLE 2179
Query: 2042 ETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNE 2101
ETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNE
Sbjct: 2180 ETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNE 2239
Query: 2102 RNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDI 2161
RNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDI
Sbjct: 2240 RNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDI 2299
Query: 2162 AGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTK 2221
AGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTK
Sbjct: 2300 AGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTK 2359
Query: 2222 VELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLL 2281
VELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLL
Sbjct: 2360 VELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLL 2419
Query: 2282 KEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSW 2341
KEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSW
Sbjct: 2420 KEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSW 2479
Query: 2342 IKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTT 2401
IKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTT
Sbjct: 2480 IKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTT 2539
Query: 2402 PAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAE 2461
PAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAE
Sbjct: 2540 PAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAE 2599
Query: 2462 LNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQ 2521
LNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQ
Sbjct: 2600 LNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQ 2659
Query: 2522 NVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNL 2581
NVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNL
Sbjct: 2660 NVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNL 2719
Query: 2582 TQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTA 2641
TQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTA
Sbjct: 2720 TQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTA 2779
Query: 2642 AGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRS 2701
AGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRS
Sbjct: 2780 AGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRS 2839
Query: 2702 LSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALV 2761
LSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALV
Sbjct: 2840 LSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALV 2899
Query: 2762 KEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKE 2821
KEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKE
Sbjct: 2900 KEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKE 2959
Query: 2822 EQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQL 2881
EQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQL
Sbjct: 2960 EQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQL 3019
Query: 2882 QLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDP 2941
QLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDP
Sbjct: 3020 QLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDP 3079
Query: 2942 AEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVT 3001
AEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVT
Sbjct: 3080 AEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVT 3139
Query: 3002 EQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQ 3061
EQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQ
Sbjct: 3140 EQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQ 3199
Query: 3062 QKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLE 3121
QKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLE
Sbjct: 3200 QKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLE 3259
Query: 3122 TKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMAS 3181
TKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMAS
Sbjct: 3260 TKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMAS 3319
Query: 3182 NDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFY 3241
NDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFY
Sbjct: 3320 NDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFY 3379
Query: 3242 SKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQ 3301
SKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQ
Sbjct: 3380 SKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQ 3439
Query: 3302 GLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSW 3361
GLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSW
Sbjct: 3440 GLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSW 3499
Query: 3362 MVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPAD 3421
MVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPAD
Sbjct: 3500 MVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPAD 3559
Query: 3422 KVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNC 3481
KVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNC
Sbjct: 3560 KVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNC 3619
Query: 3482 EPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFS 3541
EPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFS
Sbjct: 3620 EPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFS 3679
Query: 3542 QVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLW 3601
QVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLW
Sbjct: 3680 QVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLW 3739
Query: 3602 KQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLS 3661
KQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLS
Sbjct: 3740 KQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLS 3799
Query: 3662 TDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKK 3721
TDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKK
Sbjct: 3800 TDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKK 3859
Query: 3722 EAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAI 3781
EAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAI
Sbjct: 3860 EAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAI 3919
Query: 3782 LRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDD 3841
LRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDD
Sbjct: 3920 LRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDD 3979
Query: 3842 LVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYE 3901
LVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYE
Sbjct: 3980 LVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYE 4039
Query: 3902 ELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLEL 3961
ELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLEL
Sbjct: 4040 ELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLEL 4099
Query: 3962 SPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVER 4021
SPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVER
Sbjct: 4100 SPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVER 4159
Query: 4022 LRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKA 4081
LRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKA
Sbjct: 4160 LRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKA 4219
Query: 4082 VQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDP 4141
VQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDP
Sbjct: 4220 VQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDP 4279
Query: 4142 GIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSA 4201
GIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSA
Sbjct: 4280 GIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSA 4339
Query: 4202 WDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQI 4261
WDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQI
Sbjct: 4340 WDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQI 4399
Query: 4262 EELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIIN 4321
EELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIIN
Sbjct: 4400 EELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIIN 4459
Query: 4322 RQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDV 4381
RQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDV
Sbjct: 4460 RQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDV 4519
Query: 4382 LAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQ 4441
LAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQ
Sbjct: 4520 LAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQ 4579
Query: 4442 AKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLM 4501
AKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLM
Sbjct: 4580 AKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLM 4639
Query: 4502 QKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDF 4561
QKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDF
Sbjct: 4640 QKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDF 4699
Query: 4562 INWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQ 4621
INWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQ
Sbjct: 4700 INWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQ 4759
Query: 4622 KQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSL 4681
KQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSL
Sbjct: 4760 KQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSL 4819
Query: 4682 DSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDM 4741
DSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDM
Sbjct: 4820 DSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDM 4879
Query: 4742 LSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDI 4801
LSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDI
Sbjct: 4880 LSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDI 4939
Query: 4802 DLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVC 4861
DLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVC
Sbjct: 4940 DLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVC 4999
Query: 4862 ALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKE 4921
ALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKE
Sbjct: 5000 ALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKE 5059
Query: 4922 FMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLA 4981
FMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLA
Sbjct: 5060 FMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLA 5119
Query: 4982 SALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQ 5041
SALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQ
Sbjct: 5120 SALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQ 5179
Query: 5042 PDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETKNPRVNL 5101
PDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETKNPRVNL
Sbjct: 5180 PDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETKNPRVNL 5239
Query: 5102 LVSKWQQVWLLALERRRKLNDALDRLEELREFANFDFDIWRKKYMRWMNHKKSRVMDFFR 5161
LVSKWQQVWLLALERRRKLNDALDRLEELREFANFDFDIWRKKYMRWMNHKKSRVMDFFR
Sbjct: 5240 LVSKWQQVWLLALERRRKLNDALDRLEELREFANFDFDIWRKKYMRWMNHKKSRVMDFFR 5299
Query: 5162 RIDKDQDGKITRQEFIDGILSSKFPTSRLEMSAVADIFDRDGDGYIDYYEFVAALHPNKD 5221
RIDKDQDGKITRQEFIDGILSSKFPTSRLEMSAVADIFDRDGDGYIDYYEFVAALHPNKD
Sbjct: 5300 RIDKDQDGKITRQEFIDGILSSKFPTSRLEMSAVADIFDRDGDGYIDYYEFVAALHPNKD 5359
Query: 5222 AYKPITDADKIEDEVTRQVAKCKCAKRFQVEQIGDNKYRFFLGNQFGDSQQLRLVRILRS 5281
AYKPITDADKIEDEVTRQVAKCKCAKRFQVEQIGDNKYRFFLGNQFGDSQQLRLVRILRS
Sbjct: 5360 AYKPITDADKIEDEVTRQVAKCKCAKRFQVEQIGDNKYRFFLGNQFGDSQQLRLVRILRS 5419
Query: 5282 TVMVRVGGGWMALDEFLVKNDPCRAKGRTNMELREKFILADGASQGMAAFRPRGRRSRPS 5341
TVMVRVGGGWMALDEFLVKNDPCRAKGRTNMELREKFILADGASQGMAAFRPRGRRSRPS
Sbjct: 5420 TVMVRVGGGWMALDEFLVKNDPCRAKGRTNMELREKFILADGASQGMAAFRPRGRRSRPS 5479
Query: 5342 SRGASPNRSTSVSSQAAQAASPQVPATTTPKILHPLTRNYGKPWLTNSKMSTPCKAAECS 5401
SRGASPNRSTSVSSQAAQAASPQVPATTTPKILHPLTRNYGKPWLTNSKMSTPCKAAECS
Sbjct: 5480 SRGASPNRSTSVSSQAAQAASPQVPATTTPKILHPLTRNYGKPWLTNSKMSTPCKAAECS 5539
Query: 5402 DFPVPSAEGTPIQGSKLRLPGYLSGKGFHSGEDSGLITTAAARVRTQFADSKKTPSRPGS 5461
DFPVPSAEGTPIQGSKLRLPGYLSGKGFHSGEDSGLITTAAARVRTQFADSKKTPSRPGS
Sbjct: 5540 DFPVPSAEGTPIQGSKLRLPGYLSGKGFHSGEDSGLITTAAARVRTQFADSKKTPSRPGS 5599
Query: 5462 RAGSKAGSRASSRRGSDASDFDISEIQSVCSDVETVPQTHRPTPRAGSRPSTAKPSKIPT 5521
RAGSKAGSRASSRRGSDASDFDISEIQSVCSDVETVPQTHRPTPRAGSRPSTAKPSKIPT
Sbjct: 5600 RAGSKAGSRASSRRGSDASDFDISEIQSVCSDVETVPQTHRPTPRAGSRPSTAKPSKIPT 5659
Query: 5522 PQRKSPASKLDKSSKR 5537
PQRKSPASKLDKSSKR
Sbjct: 5660 PQRKSPASKLDKSSKR 5675
>gi|221316624 dystonin isoform 4 [Homo sapiens]
Length = 5526
Score = 1.083e+04 bits (28092), Expect = 0.0
Identities = 5526/5526 (100%), Positives = 5526/5526 (100%)
Query: 12 MSSSADFSDEDDFSQKSGSASPAPGDTLPWNLPKHERSKRKIQGGSVLDPAERAVLRIAD 71
MSSSADFSDEDDFSQKSGSASPAPGDTLPWNLPKHERSKRKIQGGSVLDPAERAVLRIAD
Sbjct: 1 MSSSADFSDEDDFSQKSGSASPAPGDTLPWNLPKHERSKRKIQGGSVLDPAERAVLRIAD 60
Query: 72 ERDKVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEVLSGDTLPREKGRMRFH 131
ERDKVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEVLSGDTLPREKGRMRFH
Sbjct: 61 ERDKVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEVLSGDTLPREKGRMRFH 120
Query: 132 RLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIHVTGESEDM 191
RLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIHVTGESEDM
Sbjct: 121 RLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIHVTGESEDM 180
Query: 192 SAKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAVQSNLAN 251
SAKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAVQSNLAN
Sbjct: 181 SAKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAVQSNLAN 240
Query: 252 LEHAFYVAEKIGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAFPKVPEGGEGIGANDVEV 311
LEHAFYVAEKIGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAFPKVPEGGEGIGANDVEV
Sbjct: 241 LEHAFYVAEKIGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAFPKVPEGGEGIGANDVEV 300
Query: 312 KWIEYQNMVNYLIQWIRHHVTTMSERTFPNNPVELKALYNQYLQFKETEIPPKETEKSKI 371
KWIEYQNMVNYLIQWIRHHVTTMSERTFPNNPVELKALYNQYLQFKETEIPPKETEKSKI
Sbjct: 301 KWIEYQNMVNYLIQWIRHHVTTMSERTFPNNPVELKALYNQYLQFKETEIPPKETEKSKI 360
Query: 372 KRLYKLLEIWIEFGRIKLLQGYHPNDIEKEWGKLIIAMLEREKALRPEVERLEMLQQIAN 431
KRLYKLLEIWIEFGRIKLLQGYHPNDIEKEWGKLIIAMLEREKALRPEVERLEMLQQIAN
Sbjct: 361 KRLYKLLEIWIEFGRIKLLQGYHPNDIEKEWGKLIIAMLEREKALRPEVERLEMLQQIAN 420
Query: 432 RVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLLRQHVIDVQIL 491
RVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLLRQHVIDVQIL
Sbjct: 421 RVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLLRQHVIDVQIL 480
Query: 492 IDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISGITQSLNSGFA 551
IDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISGITQSLNSGFA
Sbjct: 481 IDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISGITQSLNSGFA 540
Query: 552 QTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPSGLVPNFSSGV 611
QTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPSGLVPNFSSGV
Sbjct: 541 QTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPSGLVPNFSSGV 600
Query: 612 EPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDL 671
EPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDL
Sbjct: 601 EPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDL 660
Query: 672 PSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAKLLNTS 731
PSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAKLLNTS
Sbjct: 661 PSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAKLLNTS 720
Query: 732 RNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQK 791
RNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQK
Sbjct: 721 RNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQK 780
Query: 792 EENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFF 851
EENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFF
Sbjct: 781 EENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFF 840
Query: 852 NDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKA 911
NDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKA
Sbjct: 841 NDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKA 900
Query: 912 KTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISPTGNE 971
KTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISPTGNE
Sbjct: 901 KTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISPTGNE 960
Query: 972 AMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRA 1031
AMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRA
Sbjct: 961 AMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRA 1020
Query: 1032 SNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQEL 1091
SNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQEL
Sbjct: 1021 SNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQEL 1080
Query: 1092 LKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEK 1151
LKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEK
Sbjct: 1081 LKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEK 1140
Query: 1152 LKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKL 1211
LKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKL
Sbjct: 1141 LKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKL 1200
Query: 1212 KTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHA 1271
KTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHA
Sbjct: 1201 KTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHA 1260
Query: 1272 LEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKS 1331
LEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKS
Sbjct: 1261 LEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKS 1320
Query: 1332 LKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDEC 1391
LKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDEC
Sbjct: 1321 LKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDEC 1380
Query: 1392 QKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALV 1451
QKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALV
Sbjct: 1381 QKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALV 1440
Query: 1452 TLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPF 1511
TLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPF
Sbjct: 1441 TLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPF 1500
Query: 1512 SKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSE 1571
SKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSE
Sbjct: 1501 SKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSE 1560
Query: 1572 SLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTV 1631
SLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTV
Sbjct: 1561 SLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTV 1620
Query: 1632 ELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKC 1691
ELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKC
Sbjct: 1621 ELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKC 1680
Query: 1692 EQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAG 1751
EQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAG
Sbjct: 1681 EQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAG 1740
Query: 1752 TKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQH 1811
TKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQH
Sbjct: 1741 TKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQH 1800
Query: 1812 EKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKL 1871
EKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKL
Sbjct: 1801 EKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKL 1860
Query: 1872 THSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHK 1931
THSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHK
Sbjct: 1861 THSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHK 1920
Query: 1932 GDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGN 1991
GDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGN
Sbjct: 1921 GDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGN 1980
Query: 1992 NLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQIS 2051
NLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQIS
Sbjct: 1981 NLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQIS 2040
Query: 2052 SQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLT 2111
SQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLT
Sbjct: 2041 SQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLT 2100
Query: 2112 RSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAM 2171
RSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAM
Sbjct: 2101 RSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAM 2160
Query: 2172 NEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEK 2231
NEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEK
Sbjct: 2161 NEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEK 2220
Query: 2232 LQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPS 2291
LQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPS
Sbjct: 2221 LQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPS 2280
Query: 2292 DKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPI 2351
DKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPI
Sbjct: 2281 DKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPI 2340
Query: 2352 VQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKS 2411
VQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKS
Sbjct: 2341 VQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKS 2400
Query: 2412 GGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQK 2471
GGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQK
Sbjct: 2401 GGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQK 2460
Query: 2472 AQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKD 2531
AQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKD
Sbjct: 2461 AQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKD 2520
Query: 2532 KLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQL 2591
KLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQL
Sbjct: 2521 KLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQL 2580
Query: 2592 KQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPG 2651
KQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPG
Sbjct: 2581 KQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPG 2640
Query: 2652 EDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDN 2711
EDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDN
Sbjct: 2641 EDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDN 2700
Query: 2712 KLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELS 2771
KLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELS
Sbjct: 2701 KLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELS 2760
Query: 2772 RQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISA 2831
RQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISA
Sbjct: 2761 RQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISA 2820
Query: 2832 KLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWD 2891
KLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWD
Sbjct: 2821 KLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWD 2880
Query: 2892 TFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKL 2951
TFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKL
Sbjct: 2881 TFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKL 2940
Query: 2952 KSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCL 3011
KSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCL
Sbjct: 2941 KSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCL 3000
Query: 3012 ENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQ 3071
ENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQ
Sbjct: 3001 ENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQ 3060
Query: 3072 VDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQ 3131
VDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQ
Sbjct: 3061 VDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQ 3120
Query: 3132 NTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKM 3191
NTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKM
Sbjct: 3121 NTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKM 3180
Query: 3192 MLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILL 3251
MLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILL
Sbjct: 3181 MLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILL 3240
Query: 3252 QKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKST 3311
QKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKST
Sbjct: 3241 QKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKST 3300
Query: 3312 STQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVAN 3371
STQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVAN
Sbjct: 3301 STQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVAN 3360
Query: 3372 QKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSL 3431
QKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSL
Sbjct: 3361 QKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSL 3420
Query: 3432 LDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKL 3491
LDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKL
Sbjct: 3421 LDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKL 3480
Query: 3492 EEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEK 3551
EEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEK
Sbjct: 3481 EEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEK 3540
Query: 3552 SHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQ 3611
SHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQ
Sbjct: 3541 SHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQ 3600
Query: 3612 EDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQA 3671
EDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQA
Sbjct: 3601 EDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQA 3660
Query: 3672 LQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLD 3731
LQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLD
Sbjct: 3661 LQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLD 3720
Query: 3732 SLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAA 3791
SLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAA
Sbjct: 3721 SLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAA 3780
Query: 3792 DAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMT 3851
DAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMT
Sbjct: 3781 DAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMT 3840
Query: 3852 ACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQ 3911
ACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQ
Sbjct: 3841 ACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQ 3900
Query: 3912 SIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQE 3971
SIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQE
Sbjct: 3901 SIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQE 3960
Query: 3972 KYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAE 4031
KYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAE
Sbjct: 3961 KYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAE 4020
Query: 4032 VEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVF 4091
VEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVF
Sbjct: 4021 VEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVF 4080
Query: 4092 IWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQ 4151
IWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQ
Sbjct: 4081 IWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQ 4140
Query: 4152 QEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKD 4211
QEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKD
Sbjct: 4141 QEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKD 4200
Query: 4212 RIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEA 4271
RIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEA
Sbjct: 4201 RIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEA 4260
Query: 4272 YQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALL 4331
YQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALL
Sbjct: 4261 YQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALL 4320
Query: 4332 ALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAV 4391
ALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAV
Sbjct: 4321 ALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAV 4380
Query: 4392 NKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIED 4451
NKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIED
Sbjct: 4381 NKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIED 4440
Query: 4452 LQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARC 4511
LQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARC
Sbjct: 4441 LQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARC 4500
Query: 4512 PKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQT 4571
PKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQT
Sbjct: 4501 PKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQT 4560
Query: 4572 LNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNL 4631
LNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNL
Sbjct: 4561 LNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNL 4620
Query: 4632 LISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDP 4691
LISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDP
Sbjct: 4621 LISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDP 4680
Query: 4692 DKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDT 4751
DKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDT
Sbjct: 4681 DKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDT 4740
Query: 4752 ICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNH 4811
ICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNH
Sbjct: 4741 ICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNH 4800
Query: 4812 KAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRL 4871
KAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRL
Sbjct: 4801 KAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRL 4860
Query: 4872 EAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRA 4931
EAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRA
Sbjct: 4861 EAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRA 4920
Query: 4932 ELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQ 4991
ELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQ
Sbjct: 4921 ELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQ 4980
Query: 4992 ELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTKTY 5051
ELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTKTY
Sbjct: 4981 ELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTKTY 5040
Query: 5052 KRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETKNPRVNLLVSKWQQVWL 5111
KRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETKNPRVNLLVSKWQQVWL
Sbjct: 5041 KRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETKNPRVNLLVSKWQQVWL 5100
Query: 5112 LALERRRKLNDALDRLEELREFANFDFDIWRKKYMRWMNHKKSRVMDFFRRIDKDQDGKI 5171
LALERRRKLNDALDRLEELREFANFDFDIWRKKYMRWMNHKKSRVMDFFRRIDKDQDGKI
Sbjct: 5101 LALERRRKLNDALDRLEELREFANFDFDIWRKKYMRWMNHKKSRVMDFFRRIDKDQDGKI 5160
Query: 5172 TRQEFIDGILSSKFPTSRLEMSAVADIFDRDGDGYIDYYEFVAALHPNKDAYKPITDADK 5231
TRQEFIDGILSSKFPTSRLEMSAVADIFDRDGDGYIDYYEFVAALHPNKDAYKPITDADK
Sbjct: 5161 TRQEFIDGILSSKFPTSRLEMSAVADIFDRDGDGYIDYYEFVAALHPNKDAYKPITDADK 5220
Query: 5232 IEDEVTRQVAKCKCAKRFQVEQIGDNKYRFFLGNQFGDSQQLRLVRILRSTVMVRVGGGW 5291
IEDEVTRQVAKCKCAKRFQVEQIGDNKYRFFLGNQFGDSQQLRLVRILRSTVMVRVGGGW
Sbjct: 5221 IEDEVTRQVAKCKCAKRFQVEQIGDNKYRFFLGNQFGDSQQLRLVRILRSTVMVRVGGGW 5280
Query: 5292 MALDEFLVKNDPCRAKGRTNMELREKFILADGASQGMAAFRPRGRRSRPSSRGASPNRST 5351
MALDEFLVKNDPCRAKGRTNMELREKFILADGASQGMAAFRPRGRRSRPSSRGASPNRST
Sbjct: 5281 MALDEFLVKNDPCRAKGRTNMELREKFILADGASQGMAAFRPRGRRSRPSSRGASPNRST 5340
Query: 5352 SVSSQAAQAASPQVPATTTPKILHPLTRNYGKPWLTNSKMSTPCKAAECSDFPVPSAEGT 5411
SVSSQAAQAASPQVPATTTPKILHPLTRNYGKPWLTNSKMSTPCKAAECSDFPVPSAEGT
Sbjct: 5341 SVSSQAAQAASPQVPATTTPKILHPLTRNYGKPWLTNSKMSTPCKAAECSDFPVPSAEGT 5400
Query: 5412 PIQGSKLRLPGYLSGKGFHSGEDSGLITTAAARVRTQFADSKKTPSRPGSRAGSKAGSRA 5471
PIQGSKLRLPGYLSGKGFHSGEDSGLITTAAARVRTQFADSKKTPSRPGSRAGSKAGSRA
Sbjct: 5401 PIQGSKLRLPGYLSGKGFHSGEDSGLITTAAARVRTQFADSKKTPSRPGSRAGSKAGSRA 5460
Query: 5472 SSRRGSDASDFDISEIQSVCSDVETVPQTHRPTPRAGSRPSTAKPSKIPTPQRKSPASKL 5531
SSRRGSDASDFDISEIQSVCSDVETVPQTHRPTPRAGSRPSTAKPSKIPTPQRKSPASKL
Sbjct: 5461 SSRRGSDASDFDISEIQSVCSDVETVPQTHRPTPRAGSRPSTAKPSKIPTPQRKSPASKL 5520
Query: 5532 DKSSKR 5537
DKSSKR
Sbjct: 5521 DKSSKR 5526
>gi|34577047 dystonin isoform 1 [Homo sapiens]
Length = 5497
Score = 1.071e+04 bits (27794), Expect = 0.0
Identities = 5470/5479 (99%), Positives = 5471/5479 (99%)
Query: 59 LDPAERAVLRIADERDKVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEVLSG 118
L E + R DERDKVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEVLSG
Sbjct: 19 LQAYEDVLERYKDERDKVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEVLSG 78
Query: 119 DTLPREKGRMRFHRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQ 178
DTLPREKGRMRFHRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQ
Sbjct: 79 DTLPREKGRMRFHRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQ 138
Query: 179 ISDIHVTGESEDMSAKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLI 238
ISDIHVTGESEDMSAKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLI
Sbjct: 139 ISDIHVTGESEDMSAKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLI 198
Query: 239 DMNTVAVQSNLANLEHAFYVAEKIGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAFPKVP 298
DMNTVAVQSNLANLEHAFYVAEKIGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAFPKVP
Sbjct: 199 DMNTVAVQSNLANLEHAFYVAEKIGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAFPKVP 258
Query: 299 EGGEGIGANDVEVKWIEYQNMVNYLIQWIRHHVTTMSERTFPNNPVELKALYNQYLQFKE 358
EGGEGIGANDVEVKWIEYQNMVNYLIQWIRHHVTTMSERTFPNNPVELKALYNQYLQFKE
Sbjct: 259 EGGEGIGANDVEVKWIEYQNMVNYLIQWIRHHVTTMSERTFPNNPVELKALYNQYLQFKE 318
Query: 359 TEIPPKETEKSKIKRLYKLLEIWIEFGRIKLLQGYHPNDIEKEWGKLIIAMLEREKALRP 418
TEIPPKETEKSKIKRLYKLLEIWIEFGRIKLLQGYHPNDIEKEWGKLIIAMLEREKALRP
Sbjct: 319 TEIPPKETEKSKIKRLYKLLEIWIEFGRIKLLQGYHPNDIEKEWGKLIIAMLEREKALRP 378
Query: 419 EVERLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECE 478
EVERLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECE
Sbjct: 379 EVERLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECE 438
Query: 479 NLLRQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLM 538
NLLRQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLM
Sbjct: 439 NLLRQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLM 498
Query: 539 ISGITQSLNSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPG 598
ISGITQSLNSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPG
Sbjct: 499 ISGITQSLNSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPG 558
Query: 599 FPSGLVPNFSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEM 658
FPSGLVPNFSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEM
Sbjct: 559 FPSGLVPNFSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEM 618
Query: 659 QVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLH 718
QVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLH
Sbjct: 619 QVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLH 678
Query: 719 RLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKK 778
RLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKK
Sbjct: 679 RLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKK 738
Query: 779 DYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVE 838
DYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVE
Sbjct: 739 DYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVE 798
Query: 839 QHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELL 898
QHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELL
Sbjct: 799 QHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELL 858
Query: 899 QYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSH 958
QYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSH
Sbjct: 859 QYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSH 918
Query: 959 RAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVS 1018
RAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVS
Sbjct: 919 RAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVS 978
Query: 1019 WHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLE 1078
WHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLE
Sbjct: 979 WHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLE 1038
Query: 1079 KEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDD 1138
KEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDD
Sbjct: 1039 KEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDD 1098
Query: 1139 LHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMN 1198
LHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMN
Sbjct: 1099 LHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMN 1158
Query: 1199 QVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQW 1258
QVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQW
Sbjct: 1159 QVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQW 1218
Query: 1259 RSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQI 1318
RSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQI
Sbjct: 1219 RSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQI 1278
Query: 1319 DNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLV 1378
DNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLV
Sbjct: 1279 DNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLV 1338
Query: 1379 SEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQ 1438
SEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQ
Sbjct: 1339 SEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQ 1398
Query: 1439 EFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISK 1498
EFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISK
Sbjct: 1399 EFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISK 1458
Query: 1499 TLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQV 1558
TLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQV
Sbjct: 1459 TLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQV 1518
Query: 1559 KTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLI 1618
KTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLI
Sbjct: 1519 KTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLI 1578
Query: 1619 GHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKA 1678
GHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKA
Sbjct: 1579 GHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKA 1638
Query: 1679 LIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLD 1738
LIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLD
Sbjct: 1639 LIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLD 1698
Query: 1739 WLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQE 1798
WLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQE
Sbjct: 1699 WLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQE 1758
Query: 1799 NLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHY 1858
NLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHY
Sbjct: 1759 NLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHY 1818
Query: 1859 ETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLK 1918
ETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLK
Sbjct: 1819 ETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLK 1878
Query: 1919 RQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDR 1978
RQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDR
Sbjct: 1879 RQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDR 1938
Query: 1979 FRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQR 2038
FRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQR
Sbjct: 1939 FRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQR 1998
Query: 2039 QLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKS 2098
QLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKS
Sbjct: 1999 QLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKS 2058
Query: 2099 VNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLE 2158
VNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLE
Sbjct: 2059 VNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLE 2118
Query: 2159 QDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEEL 2218
QDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEEL
Sbjct: 2119 QDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEEL 2178
Query: 2219 KTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLH 2278
KTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLH
Sbjct: 2179 KTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLH 2238
Query: 2279 SLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSL 2338
SLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSL
Sbjct: 2239 SLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSL 2298
Query: 2339 KSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISA 2398
KSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISA
Sbjct: 2299 KSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISA 2358
Query: 2399 VTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDK 2458
VTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDK
Sbjct: 2359 VTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDK 2418
Query: 2459 IAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAE 2518
IAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAE
Sbjct: 2419 IAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAE 2478
Query: 2519 LKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESS 2578
LKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESS
Sbjct: 2479 LKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESS 2538
Query: 2579 NNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQ 2638
NNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQ
Sbjct: 2539 NNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQ 2598
Query: 2639 LTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSL 2698
LTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSL
Sbjct: 2599 LTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSL 2658
Query: 2699 LRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLS 2758
LRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLS
Sbjct: 2659 LRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLS 2718
Query: 2759 ALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDT 2818
ALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDT
Sbjct: 2719 ALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDT 2778
Query: 2819 KKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAA 2878
KKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAA
Sbjct: 2779 KKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAA 2838
Query: 2879 LQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFC 2938
LQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFC
Sbjct: 2839 LQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFC 2898
Query: 2939 LDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVD 2998
LDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVD
Sbjct: 2899 LDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVD 2958
Query: 2999 MVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTML 3058
MVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTML
Sbjct: 2959 MVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTML 3018
Query: 3059 QTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCS 3118
QTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCS
Sbjct: 3019 QTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCS 3078
Query: 3119 FLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEAL 3178
FLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEAL
Sbjct: 3079 FLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEAL 3138
Query: 3179 MASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLE 3238
MASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLE
Sbjct: 3139 MASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLE 3198
Query: 3239 EFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNW 3298
EFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNW
Sbjct: 3199 EFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNW 3258
Query: 3299 LGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESL 3358
LGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESL
Sbjct: 3259 LGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESL 3318
Query: 3359 LSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAE 3418
LSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAE
Sbjct: 3319 LSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAE 3378
Query: 3419 PADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRL 3478
PADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRL
Sbjct: 3379 PADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRL 3438
Query: 3479 VNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKL 3538
VNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKL
Sbjct: 3439 VNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKL 3498
Query: 3539 DFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTE 3598
DFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTE
Sbjct: 3499 DFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTE 3558
Query: 3599 GLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDIT 3658
GLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDIT
Sbjct: 3559 GLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDIT 3618
Query: 3659 KLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKE 3718
KLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKE
Sbjct: 3619 KLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKE 3678
Query: 3719 LKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEID 3778
LKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEID
Sbjct: 3679 LKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEID 3738
Query: 3779 AAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDI 3838
AAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDI
Sbjct: 3739 AAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDI 3798
Query: 3839 IDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWE 3898
IDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWE
Sbjct: 3799 IDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWE 3858
Query: 3899 TYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQL 3958
TYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQL
Sbjct: 3859 TYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQL 3918
Query: 3959 LELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERI 4018
LELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERI
Sbjct: 3919 LELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERI 3978
Query: 4019 VERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDIS 4078
VERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDIS
Sbjct: 3979 VERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDIS 4038
Query: 4079 AKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDL 4138
AKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDL
Sbjct: 4039 AKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDL 4098
Query: 4139 EDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDEL 4198
EDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDEL
Sbjct: 4099 EDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDEL 4158
Query: 4199 NSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVK 4258
NSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVK
Sbjct: 4159 NSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVK 4218
Query: 4259 QQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEER 4318
QQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEER
Sbjct: 4219 QQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEER 4278
Query: 4319 IINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQ 4378
IINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQ
Sbjct: 4279 IINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQ 4338
Query: 4379 NDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGA 4438
NDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGA
Sbjct: 4339 NDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGA 4398
Query: 4439 LRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYK 4498
LRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYK
Sbjct: 4399 LRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYK 4458
Query: 4499 SLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSL 4558
SLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSL
Sbjct: 4459 SLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSL 4518
Query: 4559 QDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKY 4618
QDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKY
Sbjct: 4519 QDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKY 4578
Query: 4619 FSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESE 4678
FSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESE
Sbjct: 4579 FSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESE 4638
Query: 4679 KSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKL 4738
KSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKL
Sbjct: 4639 KSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKL 4698
Query: 4739 DDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVH 4798
DDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVH
Sbjct: 4699 DDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVH 4758
Query: 4799 GDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWE 4858
GDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWE
Sbjct: 4759 GDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWE 4818
Query: 4859 TVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQ 4918
TVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQ
Sbjct: 4819 TVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQ 4878
Query: 4919 HKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQ 4978
HKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQ
Sbjct: 4879 HKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQ 4938
Query: 4979 RLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMT 5038
RLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMT
Sbjct: 4939 RLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMT 4998
Query: 5039 RKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETKNPR 5098
RKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETKNPR
Sbjct: 4999 RKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETKNPR 5058
Query: 5099 VNLLVSKWQQVWLLALERRRKLNDALDRLEELREFANFDFDIWRKKYMRWMNHKKSRVMD 5158
VNLLVSKWQQVWLLALERRRKLNDALDRLEELREFANFDFDIWRKKYMRWMNHKKSRVMD
Sbjct: 5059 VNLLVSKWQQVWLLALERRRKLNDALDRLEELREFANFDFDIWRKKYMRWMNHKKSRVMD 5118
Query: 5159 FFRRIDKDQDGKITRQEFIDGILSSKFPTSRLEMSAVADIFDRDGDGYIDYYEFVAALHP 5218
FFRRIDKDQDGKITRQEFIDGILSSKFPTSRLEMSAVADIFDRDGDGYIDYYEFVAALHP
Sbjct: 5119 FFRRIDKDQDGKITRQEFIDGILSSKFPTSRLEMSAVADIFDRDGDGYIDYYEFVAALHP 5178
Query: 5219 NKDAYKPITDADKIEDEVTRQVAKCKCAKRFQVEQIGDNKYRFFLGNQFGDSQQLRLVRI 5278
NKDAYKPITDADKIEDEVTRQVAKCKCAKRFQVEQIGDNKYRFFLGNQFGDSQQLRLVRI
Sbjct: 5179 NKDAYKPITDADKIEDEVTRQVAKCKCAKRFQVEQIGDNKYRFFLGNQFGDSQQLRLVRI 5238
Query: 5279 LRSTVMVRVGGGWMALDEFLVKNDPCRAKGRTNMELREKFILADGASQGMAAFRPRGRRS 5338
LRSTVMVRVGGGWMALDEFLVKNDPCRAKGRTNMELREKFILADGASQGMAAFRPRGRRS
Sbjct: 5239 LRSTVMVRVGGGWMALDEFLVKNDPCRAKGRTNMELREKFILADGASQGMAAFRPRGRRS 5298
Query: 5339 RPSSRGASPNRSTSVSSQAAQAASPQVPATTTPKILHPLTRNYGKPWLTNSKMSTPCKAA 5398
RPSSRGASPNRSTSVSSQAAQAASPQVPATTTPKILHPLTRNYGKPWLTNSKMSTPCKAA
Sbjct: 5299 RPSSRGASPNRSTSVSSQAAQAASPQVPATTTPKILHPLTRNYGKPWLTNSKMSTPCKAA 5358
Query: 5399 ECSDFPVPSAEGTPIQGSKLRLPGYLSGKGFHSGEDSGLITTAAARVRTQFADSKKTPSR 5458
ECSDFPVPSAEGTPIQGSKLRLPGYLSGKGFHSGEDSGLITTAAARVRTQFADSKKTPSR
Sbjct: 5359 ECSDFPVPSAEGTPIQGSKLRLPGYLSGKGFHSGEDSGLITTAAARVRTQFADSKKTPSR 5418
Query: 5459 PGSRAGSKAGSRASSRRGSDASDFDISEIQSVCSDVETVPQTHRPTPRAGSRPSTAKPSK 5518
PGSRAGSKAGSRASSRRGSDASDFDISEIQSVCSDVETVPQTHRPTPRAGSRPSTAKPSK
Sbjct: 5419 PGSRAGSKAGSRASSRRGSDASDFDISEIQSVCSDVETVPQTHRPTPRAGSRPSTAKPSK 5478
Query: 5519 IPTPQRKSPASKLDKSSKR 5537
IPTPQRKSPASKLDKSSKR
Sbjct: 5479 IPTPQRKSPASKLDKSSKR 5497
>gi|34577049 dystonin isoform 1eA precursor [Homo sapiens]
Length = 5171
Score = 9997 bits (25942), Expect = 0.0
Identities = 5116/5116 (100%), Positives = 5116/5116 (100%)
Query: 422 RLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLL 481
RLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLL
Sbjct: 56 RLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLL 115
Query: 482 RQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISG 541
RQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISG
Sbjct: 116 RQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISG 175
Query: 542 ITQSLNSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPS 601
ITQSLNSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPS
Sbjct: 176 ITQSLNSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPS 235
Query: 602 GLVPNFSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQ 661
GLVPNFSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQ
Sbjct: 236 GLVPNFSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQ 295
Query: 662 LDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLE 721
LDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLE
Sbjct: 296 LDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLE 355
Query: 722 SQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYH 781
SQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYH
Sbjct: 356 SQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYH 415
Query: 782 AELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHI 841
AELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHI
Sbjct: 416 AELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHI 475
Query: 842 KENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYK 901
KENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYK
Sbjct: 476 KENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYK 535
Query: 902 STIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAK 961
STIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAK
Sbjct: 536 STIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAK 595
Query: 962 WKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHY 1021
WKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHY
Sbjct: 596 WKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHY 655
Query: 1022 LINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEV 1081
LINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEV
Sbjct: 656 LINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEV 715
Query: 1082 NVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHE 1141
NVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHE
Sbjct: 716 NVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHE 775
Query: 1142 SVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVY 1201
SVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVY
Sbjct: 776 SVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVY 835
Query: 1202 SMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSE 1261
SMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSE
Sbjct: 836 SMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSE 895
Query: 1262 VDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNR 1321
VDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNR
Sbjct: 896 VDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNR 955
Query: 1322 LRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEI 1381
LRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEI
Sbjct: 956 LRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEI 1015
Query: 1382 EMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFM 1441
EMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFM
Sbjct: 1016 EMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFM 1075
Query: 1442 DLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLK 1501
DLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLK
Sbjct: 1076 DLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLK 1135
Query: 1502 DAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTL 1561
DAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTL
Sbjct: 1136 DAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTL 1195
Query: 1562 QESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQ 1621
QESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQ
Sbjct: 1196 QESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQ 1255
Query: 1622 EAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIE 1681
EAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIE
Sbjct: 1256 EAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIE 1315
Query: 1682 QKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLS 1741
QKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLS
Sbjct: 1316 QKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLS 1375
Query: 1742 NVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLN 1801
NVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLN
Sbjct: 1376 NVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLN 1435
Query: 1802 QQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETA 1861
QQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETA
Sbjct: 1436 QQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETA 1495
Query: 1862 LAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQK 1921
LAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQK
Sbjct: 1496 LAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQK 1555
Query: 1922 SFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRS 1981
SFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRS
Sbjct: 1556 SFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRS 1615
Query: 1982 LYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLE 2041
LYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLE
Sbjct: 1616 LYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLE 1675
Query: 2042 ETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNE 2101
ETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNE
Sbjct: 1676 ETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNE 1735
Query: 2102 RNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDI 2161
RNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDI
Sbjct: 1736 RNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDI 1795
Query: 2162 AGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTK 2221
AGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTK
Sbjct: 1796 AGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTK 1855
Query: 2222 VELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLL 2281
VELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLL
Sbjct: 1856 VELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLL 1915
Query: 2282 KEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSW 2341
KEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSW
Sbjct: 1916 KEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSW 1975
Query: 2342 IKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTT 2401
IKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTT
Sbjct: 1976 IKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTT 2035
Query: 2402 PAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAE 2461
PAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAE
Sbjct: 2036 PAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAE 2095
Query: 2462 LNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQ 2521
LNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQ
Sbjct: 2096 LNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQ 2155
Query: 2522 NVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNL 2581
NVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNL
Sbjct: 2156 NVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNL 2215
Query: 2582 TQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTA 2641
TQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTA
Sbjct: 2216 TQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTA 2275
Query: 2642 AGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRS 2701
AGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRS
Sbjct: 2276 AGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRS 2335
Query: 2702 LSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALV 2761
LSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALV
Sbjct: 2336 LSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALV 2395
Query: 2762 KEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKE 2821
KEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKE
Sbjct: 2396 KEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKE 2455
Query: 2822 EQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQL 2881
EQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQL
Sbjct: 2456 EQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQL 2515
Query: 2882 QLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDP 2941
QLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDP
Sbjct: 2516 QLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDP 2575
Query: 2942 AEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVT 3001
AEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVT
Sbjct: 2576 AEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVT 2635
Query: 3002 EQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQ 3061
EQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQ
Sbjct: 2636 EQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQ 2695
Query: 3062 QKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLE 3121
QKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLE
Sbjct: 2696 QKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLE 2755
Query: 3122 TKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMAS 3181
TKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMAS
Sbjct: 2756 TKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMAS 2815
Query: 3182 NDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFY 3241
NDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFY
Sbjct: 2816 NDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFY 2875
Query: 3242 SKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQ 3301
SKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQ
Sbjct: 2876 SKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQ 2935
Query: 3302 GLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSW 3361
GLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSW
Sbjct: 2936 GLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSW 2995
Query: 3362 MVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPAD 3421
MVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPAD
Sbjct: 2996 MVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPAD 3055
Query: 3422 KVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNC 3481
KVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNC
Sbjct: 3056 KVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNC 3115
Query: 3482 EPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFS 3541
EPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFS
Sbjct: 3116 EPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFS 3175
Query: 3542 QVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLW 3601
QVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLW
Sbjct: 3176 QVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLW 3235
Query: 3602 KQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLS 3661
KQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLS
Sbjct: 3236 KQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLS 3295
Query: 3662 TDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKK 3721
TDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKK
Sbjct: 3296 TDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKK 3355
Query: 3722 EAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAI 3781
EAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAI
Sbjct: 3356 EAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAI 3415
Query: 3782 LRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDD 3841
LRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDD
Sbjct: 3416 LRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDD 3475
Query: 3842 LVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYE 3901
LVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYE
Sbjct: 3476 LVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYE 3535
Query: 3902 ELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLEL 3961
ELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLEL
Sbjct: 3536 ELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLEL 3595
Query: 3962 SPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVER 4021
SPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVER
Sbjct: 3596 SPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVER 3655
Query: 4022 LRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKA 4081
LRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKA
Sbjct: 3656 LRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKA 3715
Query: 4082 VQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDP 4141
VQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDP
Sbjct: 3716 VQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDP 3775
Query: 4142 GIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSA 4201
GIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSA
Sbjct: 3776 GIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSA 3835
Query: 4202 WDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQI 4261
WDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQI
Sbjct: 3836 WDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQI 3895
Query: 4262 EELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIIN 4321
EELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIIN
Sbjct: 3896 EELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIIN 3955
Query: 4322 RQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDV 4381
RQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDV
Sbjct: 3956 RQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDV 4015
Query: 4382 LAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQ 4441
LAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQ
Sbjct: 4016 LAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQ 4075
Query: 4442 AKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLM 4501
AKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLM
Sbjct: 4076 AKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLM 4135
Query: 4502 QKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDF 4561
QKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDF
Sbjct: 4136 QKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDF 4195
Query: 4562 INWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQ 4621
INWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQ
Sbjct: 4196 INWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQ 4255
Query: 4622 KQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSL 4681
KQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSL
Sbjct: 4256 KQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSL 4315
Query: 4682 DSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDM 4741
DSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDM
Sbjct: 4316 DSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDM 4375
Query: 4742 LSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDI 4801
LSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDI
Sbjct: 4376 LSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDI 4435
Query: 4802 DLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVC 4861
DLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVC
Sbjct: 4436 DLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVC 4495
Query: 4862 ALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKE 4921
ALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKE
Sbjct: 4496 ALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKE 4555
Query: 4922 FMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLA 4981
FMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLA
Sbjct: 4556 FMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLA 4615
Query: 4982 SALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQ 5041
SALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQ
Sbjct: 4616 SALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQ 4675
Query: 5042 PDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETKNPRVNL 5101
PDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETKNPRVNL
Sbjct: 4676 PDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETKNPRVNL 4735
Query: 5102 LVSKWQQVWLLALERRRKLNDALDRLEELREFANFDFDIWRKKYMRWMNHKKSRVMDFFR 5161
LVSKWQQVWLLALERRRKLNDALDRLEELREFANFDFDIWRKKYMRWMNHKKSRVMDFFR
Sbjct: 4736 LVSKWQQVWLLALERRRKLNDALDRLEELREFANFDFDIWRKKYMRWMNHKKSRVMDFFR 4795
Query: 5162 RIDKDQDGKITRQEFIDGILSSKFPTSRLEMSAVADIFDRDGDGYIDYYEFVAALHPNKD 5221
RIDKDQDGKITRQEFIDGILSSKFPTSRLEMSAVADIFDRDGDGYIDYYEFVAALHPNKD
Sbjct: 4796 RIDKDQDGKITRQEFIDGILSSKFPTSRLEMSAVADIFDRDGDGYIDYYEFVAALHPNKD 4855
Query: 5222 AYKPITDADKIEDEVTRQVAKCKCAKRFQVEQIGDNKYRFFLGNQFGDSQQLRLVRILRS 5281
AYKPITDADKIEDEVTRQVAKCKCAKRFQVEQIGDNKYRFFLGNQFGDSQQLRLVRILRS
Sbjct: 4856 AYKPITDADKIEDEVTRQVAKCKCAKRFQVEQIGDNKYRFFLGNQFGDSQQLRLVRILRS 4915
Query: 5282 TVMVRVGGGWMALDEFLVKNDPCRAKGRTNMELREKFILADGASQGMAAFRPRGRRSRPS 5341
TVMVRVGGGWMALDEFLVKNDPCRAKGRTNMELREKFILADGASQGMAAFRPRGRRSRPS
Sbjct: 4916 TVMVRVGGGWMALDEFLVKNDPCRAKGRTNMELREKFILADGASQGMAAFRPRGRRSRPS 4975
Query: 5342 SRGASPNRSTSVSSQAAQAASPQVPATTTPKILHPLTRNYGKPWLTNSKMSTPCKAAECS 5401
SRGASPNRSTSVSSQAAQAASPQVPATTTPKILHPLTRNYGKPWLTNSKMSTPCKAAECS
Sbjct: 4976 SRGASPNRSTSVSSQAAQAASPQVPATTTPKILHPLTRNYGKPWLTNSKMSTPCKAAECS 5035
Query: 5402 DFPVPSAEGTPIQGSKLRLPGYLSGKGFHSGEDSGLITTAAARVRTQFADSKKTPSRPGS 5461
DFPVPSAEGTPIQGSKLRLPGYLSGKGFHSGEDSGLITTAAARVRTQFADSKKTPSRPGS
Sbjct: 5036 DFPVPSAEGTPIQGSKLRLPGYLSGKGFHSGEDSGLITTAAARVRTQFADSKKTPSRPGS 5095
Query: 5462 RAGSKAGSRASSRRGSDASDFDISEIQSVCSDVETVPQTHRPTPRAGSRPSTAKPSKIPT 5521
RAGSKAGSRASSRRGSDASDFDISEIQSVCSDVETVPQTHRPTPRAGSRPSTAKPSKIPT
Sbjct: 5096 RAGSKAGSRASSRRGSDASDFDISEIQSVCSDVETVPQTHRPTPRAGSRPSTAKPSKIPT 5155
Query: 5522 PQRKSPASKLDKSSKR 5537
PQRKSPASKLDKSSKR
Sbjct: 5156 PQRKSPASKLDKSSKR 5171
>gi|33188445 microfilament and actin filament cross-linker protein
isoform a [Homo sapiens]
Length = 5430
Score = 5941 bits (15413), Expect = 0.0
Identities = 3039/5549 (54%), Positives = 4065/5549 (73%), Gaps = 169/5549 (3%)
Query: 7 SYRCSMSSSADFSDEDDFSQKSGSASPAP-GDTLPWNLPKHERSKRKIQGGSVLDPAERA 65
S R S + S+ S++SGS SP P GDTLPWNLP HE+ KRK Q SVLDPAERA
Sbjct: 10 SERSCRSERSCRSERSYRSERSGSLSPCPPGDTLPWNLPLHEQKKRKSQD-SVLDPAERA 68
Query: 66 VLRIADERDKVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEVLSGDTLPREK 125
V+R+ADERD+VQKKTFTKW+N+HLMKVRKH+NDLYEDLRDGHNLISLLEVLSG LPREK
Sbjct: 69 VVRVADERDRVQKKTFTKWVNKHLMKVRKHINDLYEDLRDGHNLISLLEVLSGIKLPREK 128
Query: 126 GRMRFHRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIHVT 185
GRMRFHRLQNVQIALD+LK+RQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDI+++
Sbjct: 129 GRMRFHRLQNVQIALDFLKQRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIYIS 188
Query: 186 GESEDMSAKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAV 245
GES DMSAKE+LLLWTQ+ T GY GI+C NF++CW DGK+FNA+IH+YRPDL+DM V +
Sbjct: 189 GESGDMSAKEKLLLWTQKVTAGYTGIKCTNFSSCWSDGKMFNALIHRYRPDLVDMERVQI 248
Query: 246 QSNLANLEHAFYVAEKIGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAFPKVPEGGEGIG 305
QSN NLE AF VAE++GV RLLD EDVDV SPDEKSVITYVSS+YDAFPKVPEGGEGI
Sbjct: 249 QSNRENLEQAFEVAERLGVTRLLDAEDVDVPSPDEKSVITYVSSIYDAFPKVPEGGEGIS 308
Query: 306 ANDVEVKWIEYQNMVNYLIQWIRHHVTTMSERTFPNNPVELKALYNQYLQFKETEIPPKE 365
A +V+ +W EYQ+ V+ LI WI+ H MS++TFP NPVELKALYNQY+ FKETEI KE
Sbjct: 309 ATEVDSRWQEYQSRVDSLIPWIKQHTILMSDKTFPQNPVELKALYNQYIHFKETEILAKE 368
Query: 366 TEKSKIKRLYKLLEIWIEFGRIKLLQGYHPNDIEKEWGKLIIAMLEREKALRPEVERLEM 425
EK +I+ LYKLLE+WIEFGRIKL QGYHPND+E+EWGKLII MLEREK+LRP VERLE+
Sbjct: 369 REKGRIEELYKLLEVWIEFGRIKLPQGYHPNDVEEEWGKLIIEMLEREKSLRPAVERLEL 428
Query: 426 LQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLLRQHV 485
L QIAN++Q ++ CE+KL LA N LQ+D+ LESG Q E+++ YI ECE L+RQ
Sbjct: 429 LLQIANKIQNGALNCEEKLTLAKNTLQADAAHLESGQPVQCESDVIMYIQECEGLIRQLQ 488
Query: 486 IDVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISGITQS 545
+D+QIL D YYQ ++L RV +L+DE++ LR EC T L G S
Sbjct: 489 VDLQILRDENYYQLEELAFRVMRLQDELVTLRLEC--------------TNLYRKGHFTS 534
Query: 546 LNSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPSGLVP 605
L + + PS + T L + +T S TS
Sbjct: 535 L-----ELVPPSTLT------TTHLKAEPLTKATHSSSTS-------------------- 563
Query: 606 NFSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRT 665
RKP+ ++ L+ + +E+E N++FV +LL+WV+EMQ++L+R
Sbjct: 564 -----------------WFRKPMTRAELVAISSSEDEGNLRFVYELLSWVEEMQMKLERA 606
Query: 666 EWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYA 725
EWG+DLPSVE LE +++H ++EE SS+KEA++ E +M+ +YAE L +LE+QY
Sbjct: 607 EWGNDLPSVELQLETQQHIHTSVEELGSSVKEARLYEGKMSQNFHTSYAETLGKLETQYC 666
Query: 726 KLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELM 785
KL TS + RHL +LH FVSRAT ELIWLNEKEEEE+AYDWS+ N+NI+ K++Y +EL
Sbjct: 667 KLKETSSFRMRHLQSLHKFVSRATAELIWLNEKEEEELAYDWSDNNSNISAKRNYFSELT 726
Query: 786 RELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENT 845
EL++K++ +S+Q+ AE L LENHPA+ T+EAY AA+Q+Q W+ QLC CVEQH+KENT
Sbjct: 727 MELEEKQDVFRSLQDTAELLSLENHPAKQTVEAYSAAVQSQLQWMKQLCLCVEQHVKENT 786
Query: 846 AYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIA 905
AYF+FF+DA+E +LRNL+D+I+RKYSCD ++S+ +LEDL+Q+SM+EKE+L+Q KS++A
Sbjct: 787 AYFQFFSDARELESFLRNLQDSIKRKYSCDHNTSLSRLEDLLQDSMDEKEQLIQSKSSVA 846
Query: 906 NLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVI 965
+L+G++KTI+QLKPR+ D LK +I +KA+CDYRQIEITI K+DECVL +NS R KWKVI
Sbjct: 847 SLVGRSKTIVQLKPRSPDHVLKNTISVKAVCDYRQIEITICKNDECVLEDNSQRTKWKVI 906
Query: 966 SPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINE 1025
SPTGNEAMVPSVCF +PPPNK+A+++A+R+EQ YQ V+ LWH+ H+N KS++SW+YL +
Sbjct: 907 SPTGNEAMVPSVCFLIPPPNKDAIEMASRVEQSYQKVMALWHQLHVNTKSLISWNYLRKD 966
Query: 1026 IDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCK 1085
+D ++ N+ +++ PGE Q++ NLQ+ +EDFL+DS++S +FS +D +LE+EV CK
Sbjct: 967 LDLVQTWNLEKLRSSAPGECHQIMKNLQAHYEDFLQDSRDSVLFSVADRLRLEEEVEACK 1026
Query: 1086 QYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRT----PLERDDLHE 1141
+Q L+KS E E++EE+V +YISE++NIRLRLE E R++++I++ +RD +
Sbjct: 1027 ARFQHLMKSMENEDKEETVAKMYISELKNIRLRLEEYEQRVVKRIQSLASSRTDRDAWQD 1086
Query: 1142 SVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVY 1201
+ RI EQE +++L++L+ DL ++ KC+ F Q+ +SSSVPTLRSELN++++ M+ VY
Sbjct: 1087 NALRIAEQEHTQEDLQQLRSDLDAVSMKCDSFLHQSPSSSSVPTLRSELNLLVEKMDHVY 1146
Query: 1202 SMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSE 1261
+S+ Y++KLKTV++++++ Q AE LVK YE KL +EE V+AD + +E STL+ W S+
Sbjct: 1147 GLSTVYLNKLKTVDVIVRSIQDAELLVKGYEIKLSQEEVVLADLSALEAHWSTLRHWLSD 1206
Query: 1262 VDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNR 1321
V +K VF L++E+ KAK ++++M + ER+LD + ++EK QL ERW V Q++ R
Sbjct: 1207 VKDKNSVFSVLDEEIAKAKVVAEQMSRLTPERNLDLERYQEKGSQLQERWHRVIAQLEIR 1266
Query: 1322 LRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEI 1381
+LE I + L YR + L WI++ Q ++ Q E+S+ L+ QL+QQ L +EI
Sbjct: 1267 QSELESIQEVLGDYRACHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQTALFAEI 1326
Query: 1382 EMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFM 1441
E Q+K+D+CQK+++QYS VKDYELQ MTY+A V+SQQKSP KRRRM SS+D I QEFM
Sbjct: 1327 ERNQTKLDQCQKFSQQYSTIVKDYELQLMTYKAFVESQQKSPGKRRRMLSSSDAITQEFM 1386
Query: 1442 DLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLK 1501
DLRTRYTALVTL TQ++K+ D+L+RLEEEEK +EEEK+EHVEK KEL WVS +++ +
Sbjct: 1387 DLRTRYTALVTLTTQHVKYISDALRRLEEEEKVVEEEKQEHVEKVKELLGWVSTLARNTQ 1446
Query: 1502 ------------DAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDE 1549
D EKA +Q++ SEE++TKKEQ+SEA++T Q+FLAKHG K++++
Sbjct: 1447 GKATSSETKESTDIEKA----ILEQQVLSEELTTKKEQVSEAIKTSQIFLAKHGHKLSEK 1502
Query: 1550 ERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDL 1609
E+ ++ +Q+ L ++Y+ L S QLQ+ Q+ + E+K + ++Q ++L+ +C
Sbjct: 1503 EKKQISEQLNALNKAYHDLCDGSANQLQQLQSQLAHQTEQKTLQKQQNTCHQQLEDLCSW 1562
Query: 1610 LTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENG 1669
+ Q E L GHQ D + L+K QS ++LQ D+Q A + A VVK+ E F++EN
Sbjct: 1563 VGQAERALAGHQGRTTQQDLSA-LQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQ 1621
Query: 1670 EKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEES 1729
KLS + + +KL++AK + E L + ++KEL++ VT+A+++ETEK A K+L E+
Sbjct: 1622 TKLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAEN 1681
Query: 1730 KTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDV 1789
K KI+ LLDW+++V + T + + +G ++G L+T
Sbjct: 1682 KKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKG---------------ALDT-T 1725
Query: 1790 DGQVGTTQ--ENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKL 1847
DG +G Q E L++Q + +KA+H++++SQ Q I+ATQSAQ L++ G L+PEE++ L
Sbjct: 1726 DGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQML 1785
Query: 1848 QKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGA 1907
Q+ + ELK Y T+LA+SE ++K +LQ+EL+KF D+ EFE WL++SE+ELEN+ G
Sbjct: 1786 QQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGG 1845
Query: 1908 DDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHRE 1967
L + LKRQ SFSEDVISHKGDLR++TISG +VL+ S + GK + S
Sbjct: 1846 SSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKE---GK-EPSEIGNL 1901
Query: 1968 VQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSE 2027
V+ KL AT+R+ +L+SKC LG++L L+ +Y +++++ L A +QACEA K LS+
Sbjct: 1902 VKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSD 1961
Query: 2028 PIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDD 2087
+A DP LQ QL TK LQ +++ QV VEKL+K A +++ G P +Q+T D
Sbjct: 1962 TVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDS 2021
Query: 2088 IVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTAL 2147
I+ ++ LS S+ ER+ LQ + +S SVQ+ L+ +L +G VE +L+ + L+S +
Sbjct: 2022 ILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVI 2081
Query: 2148 QDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHK 2207
Q+ ++ N+ L+QDIA ++SS+ A E V +FMET D +TA+ LQ K+ ++S RF + +
Sbjct: 2082 QEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQ 2141
Query: 2208 HKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEF 2267
+E + +++L + E+FE+LS KLQ F+E K++ L + P +D+T Q +QE E
Sbjct: 2142 QQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEM 2201
Query: 2268 LEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQ 2327
+ +++L+ L L+ E+SS G D ++ NL K F E++ T+KE+++ +SCQEQ
Sbjct: 2202 EDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREKDASSCQEQ 2261
Query: 2328 LDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNN 2387
LD F+ LV++ + W+KET +P + S A++L K +E K L + W+ K ++++N
Sbjct: 2262 LDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINC 2321
Query: 2388 SGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHG 2447
G SL NLI +T P + K+G + + + + + K LT I+ DM+D++
Sbjct: 2322 KGTSLENLIMEITAPD---SQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLK 2378
Query: 2448 YEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKT 2507
YE LG +L ++ L L+++++ +E+++++QWL+ + +PT TE VK
Sbjct: 2379 YEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKA 2438
Query: 2508 QVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLT 2567
Q E NK+F AEL+QN K+Q++K+ L LL P++ EA WK++ E++S+W+ ++T
Sbjct: 2439 QAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVT 2498
Query: 2568 IDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQ 2627
+ RQ++LEES+++L FQ E+QL+ WL+EKELM+ VLGPLSIDPNMLN Q+QQVQ +L+
Sbjct: 2499 VARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLK 2558
Query: 2628 EFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQ 2687
EF R+ Q+EQL A QGIL+ PG+ V+++L ++ QKW LT +L+ R IDQ
Sbjct: 2559 EFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQ 2618
Query: 2688 AIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQI 2747
AIVKSTQYQ LL+ LS+K+ + +LS A+ST P+A+ QQLE +++ +++Q ++
Sbjct: 2619 AIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEV 2678
Query: 2748 KVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQ 2807
K AQ LC++LS L+ E+YLK EL ++LE + + +E A + + LQ+A AS+ QFQQ
Sbjct: 2679 KEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQ 2738
Query: 2808 MSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENL 2867
M + + WLD K+ +Q K+ PISAKL+ L+S ++++++F K+L S YE +AEGE+L
Sbjct: 2739 MFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESL 2798
Query: 2868 LLKTQ-GSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWID 2926
LL G EK LQ QL +K +W+ +K+ +R+++LK+ ++KA KY+ VE L PWI+
Sbjct: 2799 LLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIE 2858
Query: 2927 KCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVV 2986
C+ + E++ LDP + E+S+ + K++ E+++ ++E+LN+ A+ L++ E D++ +
Sbjct: 2859 DCKAKMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGI 2918
Query: 2987 TDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLG 3046
DE + Q +D VTE+L +K LE MTQ+ +EFQE K +++++ AK QL+I D+LG
Sbjct: 2919 RDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALG 2978
Query: 3047 SQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEH 3106
SQA SNK L L+ QQ+ LQAL+ QVD + Q LV +A D S +L Q E QE
Sbjct: 2979 SQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEF 3038
Query: 3107 STLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKE 3166
+ Q+V+ C +E KL+GIG F +REMFSQ A+ DDELD M +GRD ++LQ Q E
Sbjct: 3039 LEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIE 3098
Query: 3167 TIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAR 3226
++ FL K+ L + + C+ ML EE + DL+G+KR+LEAL+KQC KL +R +AR
Sbjct: 3099 DVRLFLNKIHVLKLDIEASEAECRHMLE-EEGTLDLLGLKRELEALNKQCGKLTERGKAR 3157
Query: 3227 EEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEI 3286
+EQ+E T+ R+E+FY KLK + AEE E Q VG E E INQQL FK+FQKE++
Sbjct: 3158 QEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQV 3217
Query: 3287 EPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALL 3346
+PLQ K Q VN LGQGLIQSA K QGLEHD++++NARW TLNKKVAQR AQLQEALL
Sbjct: 3218 DPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALL 3277
Query: 3347 HCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVI 3406
HCG+FQDALE LLSW+ DTEEL+ANQKPPSAE+KVVKAQIQEQKLLQRLLDDRK+TV+++
Sbjct: 3278 HCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDML 3337
Query: 3407 KREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEP 3466
+ EG +IA +AE AD+ KI QL L+SRW LL+KA R +QLE I V+A+QFHET EP
Sbjct: 3338 QAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEP 3397
Query: 3467 LNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLS 3526
++++L+ EK+L N EP+GTQ +K+++QI +HKALE+DI NH +HQAV IGQSL L+
Sbjct: 3398 ISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLT 3457
Query: 3527 SREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDK 3586
S ++ ++ K+D Q Y EIQ++ ++ LL QAL NA++FGEDEVE++NWL EV DK
Sbjct: 3458 SPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDK 3517
Query: 3587 LSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDK 3646
LS + V+D+ + L +Q ++ L E+I+ RK+NVDQA+ NG LLKQTTG+EVL+IQ+K
Sbjct: 3518 LSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEK 3577
Query: 3647 LEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKG 3706
L+ IK RY DIT S+ +TLEQA QLA + ST+EEL WL +VE EL + Q G
Sbjct: 3578 LDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTG 3637
Query: 3707 EEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLV 3766
E+ Q Q R KELKKE ++ +LD++NEVS ALLELVPWRAREGL+K+V++ NE+Y+LV
Sbjct: 3638 EQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLV 3697
Query: 3767 SDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQK 3826
SDTI Q+V+EIDAAI RSQQ++QAADAEL+W+ ET++KLM+LG IRLEQDQT+AQLQVQK
Sbjct: 3698 SDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQK 3757
Query: 3827 TFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQL 3886
F+++I+RHKD +D+L +I C EE+K +++K + +++ Y+ I +NSERY +L
Sbjct: 3758 AFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARL 3817
Query: 3887 ERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKP 3946
ERAQ LVNQFWETYEEL PW+ ET+++I+QLP+PA+++E LRQQQEE RQLRE IAEHKP
Sbjct: 3818 ERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKP 3877
Query: 3947 HIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQ--- 4003
HIDK+ K GPQL EL+P EG ++EKY A+ +Y+QIKE+V++RA+ALDEA+SQSTQ
Sbjct: 3878 HIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITE 3937
Query: 4004 FHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRG 4063
FHDKI+ +LE+LE + RLR PP I AEV+KI+E IS+NK+ +V++EKLQP +E LK+RG
Sbjct: 3938 FHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRG 3997
Query: 4064 EEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMS 4123
EE+I RS G DKD++AK +QDKLDQMVF WE+I EERE K LDV+ELAEKFW D +
Sbjct: 3998 EELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAA 4057
Query: 4124 LIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAAC 4183
L+ TIKDTQD + DLE PGIDPS++KQQ EAAETI+EE DGL EEL+ + LG++LI AC
Sbjct: 4058 LLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFAC 4117
Query: 4184 GEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGK 4243
GE +KP V+KSIDE+N+AW++LNK WK+R++KLE+AMQAAVQYQD LQA+FDW+D K
Sbjct: 4118 GETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIK 4177
Query: 4244 LASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQD 4303
L +M P+GTDL TVK Q+ E+K+FK E YQQQIEME+LNHQ EL+LKK T+E+D+ +++
Sbjct: 4178 LCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIRE 4237
Query: 4304 PLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGD 4363
PL ELK +W++L E+I +RQHKLEGALLALGQFQHAL+EL++WLTHTE LL Q+P+ GD
Sbjct: 4238 PLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGD 4297
Query: 4364 PKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQN 4423
PK IE+ELAKHHVL+NDVLAHQ+TVE VNKAGN+L+ESSAG++AS+L+++LE +NQ W++
Sbjct: 4298 PKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWES 4357
Query: 4424 VLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVH 4483
VL+KTE+R+QQL L+QA+GFH EIED LT E L ASKP GGLPETA+EQL+ H
Sbjct: 4358 VLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTH 4417
Query: 4484 MEVCAAFEAKEETYKSLMQKGQQM-LARCPKSAETNIDQDINNLKEKWESVETKLNERKT 4542
ME+ + +AKEETY L+ KG+ M L+R + + +Q + L++KW V +K+ ERK+
Sbjct: 4418 MELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKS 4477
Query: 4543 KLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSH 4602
KLEEALNLA EF NSLQ+FINWLT AEQ+LN+AS PSLIL+TVL QI+EHKVFANEVN+H
Sbjct: 4478 KLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAH 4537
Query: 4603 REQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQ 4662
R+QIIELD+TG LK+ SQKQDVVLIKNLL+SVQSRWEKVVQR +ERGRSLDDARKRAKQ
Sbjct: 4538 RDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQ 4597
Query: 4663 FHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTG 4722
FHEAW KL++WLE++E LDSELEI+NDPDKIK QL++HKEFQK+LG K VYDTT RTG
Sbjct: 4598 FHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTG 4657
Query: 4723 RSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALID 4782
R+LKEKT L +D+ KLD+ L E+RDKWDT+CGKSVERQ+KLEEALLFSGQF DALQAL+D
Sbjct: 4658 RALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVD 4717
Query: 4783 WLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDD 4842
WLY+VEPQLAEDQPVHGD+DLVMNL+D HK FQKELGKRT +VQ LKRS RELIE SRDD
Sbjct: 4718 WLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDD 4777
Query: 4843 SSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFH 4902
++WVK Q+QELSTRW+TVC LS+SKQ+RLE AL+QAE F VH LLEWL+EAEQTLRF
Sbjct: 4778 TTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFR 4837
Query: 4903 GVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITII 4962
G LPDD +AL++LID HKEFMKK+EEKR ++N A MG+ +LA+CHPD ITTIKHWITII
Sbjct: 4838 GALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITII 4897
Query: 4963 RARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEE 5022
RARFEEVL WAKQHQQRL +AL+ L+A ELLE LLAW+QWAETTL +D+E IPQ I+
Sbjct: 4898 RARFEEVLTWAKQHQQRLETALSELVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDR 4957
Query: 5023 VKALIAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRA-GRKRFPAS 5081
VKALIAEHQTFMEEMTRKQPDVD+VTKTYKR+ +P +H P ++K R+ GRK
Sbjct: 4958 VKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNIEP----THAPFIEKSRSGGRKSLSQP 5013
Query: 5082 SLYPSGSQTQIETKNPRVNLLVSKWQQVWLLALERRRKLNDALDRLEELREFANFDFDIW 5141
+ P +Q E KNPR+N L ++WQQVWLLALER+RKLNDALDRLEEL+EFANFDFD+W
Sbjct: 5014 TPPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKLNDALDRLEELKEFANFDFDVW 5073
Query: 5142 RKKYMRWMNHKKSRVMDFFRRIDKDQDGKITRQEFIDGILSSKFPTSRLEMSAVADIFDR 5201
RKKYMRWMNHKKSRVMDFFRRIDKDQDGKITRQEFIDGIL+SKFPT++LEM+AVADIFDR
Sbjct: 5074 RKKYMRWMNHKKSRVMDFFRRIDKDQDGKITRQEFIDGILASKFPTTKLEMTAVADIFDR 5133
Query: 5202 DGDGYIDYYEFVAALHPNKDAYKPITDADKIEDEVTRQVAKCKCAKRFQVEQIGDNKYRF 5261
DGDGYIDYYEFVAALHPNKDAY+P TDADKIEDEVTRQVA+CKCAKRFQVEQIG+NKYR
Sbjct: 5134 DGDGYIDYYEFVAALHPNKDAYRPTTDADKIEDEVTRQVAQCKCAKRFQVEQIGENKYR- 5192
Query: 5262 FLGNQFGDSQQLRLVRILRSTVMVRVGGGWMALDEFLVKNDPCRAKGRTNMELREKFILA 5321
FGDSQQLRLVRILRSTVMVRVGGGWMALDEFLVKNDPCRA+GRTN+ELREKFIL
Sbjct: 5193 -----FGDSQQLRLVRILRSTVMVRVGGGWMALDEFLVKNDPCRARGRTNIELREKFILP 5247
Query: 5322 DGASQGMAAFRPRGRRSRPSSRGASPNRSTSVSSQAAQAAS--PQVPATTTPKILHPLTR 5379
+GASQGM FR RGRRS+PSSR ASP RS+S +SQ+ + + P PAT
Sbjct: 5248 EGASQGMTPFRSRGRRSKPSSRAASPTRSSSSASQSNHSCTSMPSSPAT----------- 5296
Query: 5380 NYGKPWLTNSKMSTPCKAAECSDFPVPSAEGTPIQGSKLR--LPGYLSGKGFHSGEDSGL 5437
P + P GSKL+ P + S + +G+ S
Sbjct: 5297 ------------------------PASGTKVIPSSGSKLKRPTPTFHSSRTSLAGDTSNS 5332
Query: 5438 ITTAAARVRTQFADSKKTPSRPGSRAGSKAGSRASSRRGSDASDFDISEIQSVCSDVETV 5497
+ A+ +T AD KK+ SRPGSRAGS+AGSRASSRRGSDASDFD+ E QS CSD
Sbjct: 5333 SSPASTGAKTNRADPKKSASRPGSRAGSRAGSRASSRRGSDASDFDLLETQSACSDTS-- 5390
Query: 5498 PQTHRPTPRAGSRPSTAKPSKIPTPQRKS 5526
++ + SR KPSKIPT +K+
Sbjct: 5391 -ESSAAGGQGNSRRGLNKPSKIPTMSKKT 5418
>gi|33188443 microfilament and actin filament cross-linker protein
isoform b [Homo sapiens]
Length = 5938
Score = 4237 bits (10988), Expect = 0.0
Identities = 2190/4089 (53%), Positives = 2948/4089 (72%), Gaps = 96/4089 (2%)
Query: 1467 RLEEEEKSLEEEK----KEHVE---KAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSE 1519
RL + ++E EK +H + + ++L+ WV N + L + + +
Sbjct: 1905 RLLHFQNAVEIEKTKVLNQHTQLEGRLQDLRAWVGNKNLILNSKGSNSEIDVDSLNLCLQ 1964
Query: 1520 E-------ISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSES 1572
+ ++ +K QL IQ F+++H ++ ++ ++ + + LQ S+ + ++
Sbjct: 1965 QYEDLKQPMAERKAQLDALAFDIQFFISEHAQDLSPQQNRQMLRLLNELQRSFQDILEQT 2024
Query: 1573 LKQLQESQTSGDVKVEEKIVAERQQEYK---EKLQGICDLLTQTENRLIGHQEAFMIGDG 1629
Q+ Q +E +V Q++ ++L+ +C + Q E L GHQ D
Sbjct: 2025 AAQVDALQGHLQQMEQEALVKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDL 2084
Query: 1630 TVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKI 1689
+ L+K QS ++LQ D+Q A + A VVK+ E F++EN KLS + + +KL++AK
Sbjct: 2085 SA-LQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKE 2143
Query: 1690 KCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSER 1749
+ E L + ++KEL++ VT+A+++ETEK A K+L E+K KI+ LLDW+++V +
Sbjct: 2144 QYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQ 2203
Query: 1750 AGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQ--ENLNQQYQKV 1807
T + + +G ++G L+T DG +G Q E L++Q + +
Sbjct: 2204 LLTNLPGMEQLSGASLEKG---------------ALDT-TDGYMGVNQAPEKLDKQCEMM 2247
Query: 1808 KAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEK 1867
KA+H++++SQ Q I+ATQSAQ L++ G L+PEE++ LQ+ + ELK Y T+LA+SE
Sbjct: 2248 KARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEA 2307
Query: 1868 KMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDV 1927
++K +LQ+EL+KF D+ EFE WL++SE+ELEN+ G L + LKRQ SFSEDV
Sbjct: 2308 ELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDV 2367
Query: 1928 ISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCN 1987
ISHKGDLR++TISG +VL+ S + GK + S V+ KL AT+R+ +L+SKC
Sbjct: 2368 ISHKGDLRFVTISGQKVLDMENSFKE---GK-EPSEIGNLVKDKLKDATERYTALHSKCT 2423
Query: 1988 VLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQ 2047
LG++L L+ +Y +++++ L A +QACEA K LS+ +A DP LQ QL TK LQ
Sbjct: 2424 RLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQ 2483
Query: 2048 GQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQ 2107
+++ QV VEKL+K A +++ G P +Q+T D I+ ++ LS S+ ER+ LQ
Sbjct: 2484 EELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQ 2543
Query: 2108 ITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSS 2167
+ +S SVQ+ L+ +L +G VE +L+ + L+S +Q+ ++ N+ L+QDIA ++SS
Sbjct: 2544 KAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSS 2603
Query: 2168 INAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFEN 2227
+ A E V +FMET D +TA+ LQ K+ ++S RF + + +E + +++L + E+FE+
Sbjct: 2604 LEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEH 2663
Query: 2228 LSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSH 2287
LS KLQ F+E K++ L + P +D+T Q +QE E + +++L+ L L+ E+SS
Sbjct: 2664 LSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSC 2723
Query: 2288 GLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTK 2347
G D ++ NL K F E++ T+KE+++ +SCQEQLD F+ LV++ + W+KET
Sbjct: 2724 GFALDLCQHQDRVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEG 2783
Query: 2348 KVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIA 2407
+P + S A++L K +E K L + W+ K ++++N G SL NLI +T P +
Sbjct: 2784 SIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPD---S 2840
Query: 2408 AVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLS 2467
K+G + + + + + K LT I+ DM+D++ YE LG +L ++ L L+
Sbjct: 2841 QGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILN 2900
Query: 2468 KLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQ 2527
++++ +E+++++QWL+ + +PT TE VK Q E NK+F AEL+QN K+Q
Sbjct: 2901 RMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQ 2960
Query: 2528 ELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTV 2587
++K+ L LL P++ EA WK++ E++S+W+ ++T+ RQ++LEES+++L FQ
Sbjct: 2961 KVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAA 3020
Query: 2588 EAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGIL 2647
E+QL+ WL+EKELM+ VLGPLSIDPNMLN Q+QQVQ +L+EF R+ Q+EQL A QGIL
Sbjct: 3021 ESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGIL 3080
Query: 2648 SRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLS 2707
+ PG+ V+++L ++ QKW LT +L+ R IDQAIVKSTQYQ LL+ LS+K+
Sbjct: 3081 TGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVR 3140
Query: 2708 DLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLK 2767
+ +LS A+ST P+A+ QQLE +++ +++Q ++K AQ LC++LS L+ E+YLK
Sbjct: 3141 AVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLK 3200
Query: 2768 AELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSH 2827
EL ++LE + + +E A + + LQ+A AS+ QFQQM + + WLD K+ +Q K+
Sbjct: 3201 DELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNC 3260
Query: 2828 PISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQ-GSEKAALQLQLNTI 2886
PISAKL+ L+S ++++++F K+L S YE +AEGE+LLL G EK LQ QL +
Sbjct: 3261 PISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVEL 3320
Query: 2887 KTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGEN 2946
K +W+ +K+ +R+++LK+ ++KA KY+ VE L PWI+ C+ + E++ LDP + E+
Sbjct: 3321 KNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLES 3380
Query: 2947 SIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHS 3006
S+ + K++ E+++ ++E+LN+ A+ L++ E D++ + DE + Q +D VTE+L +
Sbjct: 3381 SLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQA 3440
Query: 3007 KKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQ 3066
K LE MTQ+ +EFQE K +++++ AK QL+I D+LGSQA SNK L L+ QQ+ LQ
Sbjct: 3441 KTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQ 3500
Query: 3067 ALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQG 3126
AL+ QVD + Q LV +A D S +L Q E QE + Q+V+ C +E KL+G
Sbjct: 3501 ALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEG 3560
Query: 3127 IGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNAN 3186
IG F +REMFSQ A+ DDELD M +GRD ++LQ Q E ++ FL K+ L + +
Sbjct: 3561 IGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASE 3620
Query: 3187 KTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKE 3246
C+ ML EE + DL+G+KR+LEAL+KQC KL +R +AR+EQ+E T+ R+E+FY KLK
Sbjct: 3621 AECRHMLE-EEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKG 3679
Query: 3247 FSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQS 3306
+ AEE E Q VG E E INQQL FK+FQKE+++PLQ K Q VN LGQGLIQS
Sbjct: 3680 LNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQS 3739
Query: 3307 AAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTE 3366
A K QGLEHD++++NARW TLNKKVAQR AQLQEALLHCG+FQDALE LLSW+ DTE
Sbjct: 3740 AGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTE 3799
Query: 3367 ELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKIL 3426
EL+ANQKPPSAE+KVVKAQIQEQKLLQRLLDDRK+TV++++ EG +IA +AE AD+ KI
Sbjct: 3800 ELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKIT 3859
Query: 3427 KQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGT 3486
QL L+SRW LL+KA R +QLE I V+A+QFHET EP++++L+ EK+L N EP+GT
Sbjct: 3860 GQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGT 3919
Query: 3487 QASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYI 3546
Q +K+++QI +HKALE+DI NH +HQAV IGQSL L+S ++ ++ K+D Q Y
Sbjct: 3920 QTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYS 3979
Query: 3547 EIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSE 3606
EIQ++ ++ LL QAL NA++FGEDEVE++NWL EV DKLS + V+D+ + L +Q ++
Sbjct: 3980 EIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHAD 4039
Query: 3607 LRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAK 3666
L E+I+ RK+NVDQA+ NG LLKQTTG+EVL+IQ+KL+ IK RY DIT S+ +
Sbjct: 4040 HLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALR 4099
Query: 3667 TLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNN 3726
TLEQA QLA + ST+EEL WL +VE EL + Q GE+ Q Q R KELKKE +
Sbjct: 4100 TLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEH 4159
Query: 3727 KALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQ 3786
+ +LD++NEVS ALLELVPWRAREGL+K+V++ NE+Y+LVSDTI Q+V+EIDAAI RSQQ
Sbjct: 4160 RLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQ 4219
Query: 3787 FDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSG 3846
++QAADAEL+W+ ET++KLM+LG IRLEQDQT+AQLQVQK F+++I+RHKD +D+L
Sbjct: 4220 YEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHR 4279
Query: 3847 HKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPW 3906
+I C EE+K +++K + +++ Y+ I +NSERY +LERAQ LVNQFWETYEEL PW
Sbjct: 4280 SEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPW 4339
Query: 3907 LTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEG 3966
+ ET+++I+QLP+PA+++E LRQQQEE RQLRE IAEHKPHIDK+ K GPQL EL+P EG
Sbjct: 4340 IEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEG 4399
Query: 3967 FSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQ---FHDKIDQILESLERIVERLR 4023
++EKY A+ +Y+QIKE+V++RA+ALDEA+SQSTQ FHDKI+ +LE+LE + RLR
Sbjct: 4400 EMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLR 4459
Query: 4024 QPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQ 4083
PP I AEV+KI+E IS+NK+ +V++EKLQP +E LK+RGEE+I RS G DKD++AK +Q
Sbjct: 4460 MPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQ 4519
Query: 4084 DKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGI 4143
DKLDQMVF WE+I EERE K LDV+ELAEKFW D +L+ TIKDTQD + DLE PGI
Sbjct: 4520 DKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGI 4579
Query: 4144 DPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWD 4203
DPS++KQQ EAAETI+EE DGL EEL+ + LG++LI ACGE +KP V+KSIDE+N+AW+
Sbjct: 4580 DPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWE 4639
Query: 4204 SLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEE 4263
+LNK WK+R++KLE+AMQAAVQYQD LQA+FDW+D KL +M P+GTDL TVK Q+ E
Sbjct: 4640 NLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNE 4699
Query: 4264 LKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQ 4323
+K+FK E YQQQIEME+LNHQ EL+LKK T+E+D+ +++PL ELK +W++L E+I +RQ
Sbjct: 4700 MKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQ 4759
Query: 4324 HKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLA 4383
HKLEGALLALGQFQHAL+EL++WLTHTE LL Q+P+ GDPK IE+ELAKHHVL+NDVLA
Sbjct: 4760 HKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLA 4819
Query: 4384 HQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAK 4443
HQ+TVE VNKAGN+L+ESSAG++AS+L+++LE +NQ W++VL+KTE+R+QQL L+QA+
Sbjct: 4820 HQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQ 4879
Query: 4444 GFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQK 4503
GFH EIED LT E L ASKP GGLPETA+EQL+ HME+ + +AKEETY L+ K
Sbjct: 4880 GFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDK 4939
Query: 4504 GQQM-LARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFI 4562
G+ M L+R + + +Q + L++KW V +K+ ERK+KLEEALNLA EF NSLQ+FI
Sbjct: 4940 GRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFI 4999
Query: 4563 NWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQK 4622
NWLT AEQ+LN+AS PSLIL+TVL QI+EHKVFANEVN+HR+QIIELD+TG LK+ SQK
Sbjct: 5000 NWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQK 5059
Query: 4623 QDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLD 4682
QDVVLIKNLL+SVQSRWEKVVQR +ERGRSLDDARKRAKQFHEAW KL++WLE++E LD
Sbjct: 5060 QDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLD 5119
Query: 4683 SELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDML 4742
SELEI+NDPDKIK QL++HKEFQK+LG K VYDTT RTGR+LKEKT L +D+ KLD+ L
Sbjct: 5120 SELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFL 5179
Query: 4743 SELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDID 4802
E+RDKWDT+CGKSVERQ+KLEEALLFSGQF DALQAL+DWLY+VEPQLAEDQPVHGD+D
Sbjct: 5180 GEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLD 5239
Query: 4803 LVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCA 4862
LVMNL+D HK FQKELGKRT +VQ LKRS RELIE SRDD++WVK Q+QELSTRW+TVC
Sbjct: 5240 LVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVCK 5299
Query: 4863 LSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEF 4922
LS+SKQ+RLE AL+QAE F VH LLEWL+EAEQTLRF G LPDD +AL++LID HKEF
Sbjct: 5300 LSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHKEF 5359
Query: 4923 MKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLAS 4982
MKK+EEKR ++N A MG+ +LA+CHPD ITTIKHWITIIRARFEEVL WAKQHQQRL +
Sbjct: 5360 MKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITIIRARFEEVLTWAKQHQQRLET 5419
Query: 4983 ALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQP 5042
AL+ L+A ELLE LLAW+QWAETTL +D+E IPQ I+ VKALIAEHQTFMEEMTRKQP
Sbjct: 5420 ALSELVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQP 5479
Query: 5043 DVDKVTKTYKRRAADPSSLQSHIPVLDKGRA-GRKRFPASSLYPSGSQTQIETKNPRVNL 5101
DVD+VTKTYKR+ +P +H P ++K R+ GRK + P +Q E KNPR+N
Sbjct: 5480 DVDRVTKTYKRKNIEP----THAPFIEKSRSGGRKSLSQPTPPPMPILSQSEAKNPRINQ 5535
Query: 5102 LVSKWQQVWLLALERRRKLNDALDRLEELREFANFDFDIWRKKYMRWMNHKKSRVMDFFR 5161
L ++WQQVWLLALER+RKLNDALDRLEEL+EFANFDFD+WRKKYMRWMNHKKSRVMDFFR
Sbjct: 5536 LSARWQQVWLLALERQRKLNDALDRLEELKEFANFDFDVWRKKYMRWMNHKKSRVMDFFR 5595
Query: 5162 RIDKDQDGKITRQEFIDGILSSKFPTSRLEMSAVADIFDRDGDGYIDYYEFVAALHPNKD 5221
RIDKDQDGKITRQEFIDGIL+SKFPT++LEM+AVADIFDRDGDGYIDYYEFVAALHPNKD
Sbjct: 5596 RIDKDQDGKITRQEFIDGILASKFPTTKLEMTAVADIFDRDGDGYIDYYEFVAALHPNKD 5655
Query: 5222 AYKPITDADKIEDEVTRQVAKCKCAKRFQVEQIGDNKYRFFLGNQFGDSQQLRLVRILRS 5281
AY+P TDADKIEDEVTRQVA+CKCAKRFQVEQIG+NKYRFFLGNQFGDSQQLRLVRILRS
Sbjct: 5656 AYRPTTDADKIEDEVTRQVAQCKCAKRFQVEQIGENKYRFFLGNQFGDSQQLRLVRILRS 5715
Query: 5282 TVMVRVGGGWMALDEFLVKNDPCRAKGRTNMELREKFILADGASQGMAAFRPRGRRSRPS 5341
TVMVRVGGGWMALDEFLVKNDPCRA+GRTN+ELREKFIL +GASQGM FR RGRRS+PS
Sbjct: 5716 TVMVRVGGGWMALDEFLVKNDPCRARGRTNIELREKFILPEGASQGMTPFRSRGRRSKPS 5775
Query: 5342 SRGASPNRSTSVSSQAAQAAS--PQVPATTTPKILHPLTRNYGKPWLTNSKMSTPCKAAE 5399
SR ASP RS+S +SQ+ + + P PAT
Sbjct: 5776 SRAASPTRSSSSASQSNHSCTSMPSSPAT------------------------------- 5804
Query: 5400 CSDFPVPSAEGTPIQGSKLR--LPGYLSGKGFHSGEDSGLITTAAARVRTQFADSKKTPS 5457
P + P GSKL+ P + S + +G+ S + A+ +T AD KK+ S
Sbjct: 5805 ----PASGTKVIPSSGSKLKRPTPTFHSSRTSLAGDTSNSSSPASTGAKTNRADPKKSAS 5860
Query: 5458 RPGSRAGSKAGSRASSRRGSDASDFDISEIQSVCSDVETVPQTHRPTPRAGSRPSTAKPS 5517
RPGSRAGS+AGSRASSRRGSDASDFD+ E QS CSD ++ + SR KPS
Sbjct: 5861 RPGSRAGSRAGSRASSRRGSDASDFDLLETQSACSDTS---ESSAAGGQGNSRRGLNKPS 5917
Query: 5518 KIPTPQRKS 5526
KIPT +K+
Sbjct: 5918 KIPTMSKKT 5926
Score = 687 bits (1772), Expect = 0.0
Identities = 815/3917 (20%), Positives = 1653/3917 (42%), Gaps = 407/3917 (10%)
Query: 1206 TYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEV--- 1262
+Y+ L+ + + K Q E + + LC+ + + + ++ L+S + +++
Sbjct: 1812 SYLSLLRNIEMRTKQIQPLELNLAELQDLLCQAKVLERELKDLTTLVSQELECVNQIIIS 1871
Query: 1263 ---DEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQID 1319
+ Q+ ALE + + + + T+ R L F E V N H Q++
Sbjct: 1872 QPQEVPAQLLKALEKDAKNLQKSLSSVSDTWNSRLLHFQNAVEIEKTKV---LNQHTQLE 1928
Query: 1320 NRLRDL----------------------EGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQ 1357
RL+DL + + L+ Y D P+ + Q++ IQ
Sbjct: 1929 GRLQDLRAWVGNKNLILNSKGSNSEIDVDSLNLCLQQYEDLKQPMAERKAQLDALAFDIQ 1988
Query: 1358 ENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVD 1417
E+++ L+ Q N+Q ML E+++S D ++ A Q A LQ M A+V
Sbjct: 1989 FFISEHAQDLSPQQNRQ-MLRLLNELQRSFQDILEQTAAQVDAL--QGHLQQMEQEALV- 2044
Query: 1418 SQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEE 1477
+ +Q + Q+ DL + + AG + +++ +L++
Sbjct: 2045 ---------KTLQKQQNTCHQQLEDLCSWVGQAERAL------AGHQGRTTQQDLSALQK 2089
Query: 1478 EKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQL 1537
+ + + ++Q ++ + +KD E G ++ K+S E++ +E+L +A
Sbjct: 2090 NQSDLKDLQDDIQNRATSFATVVKDIE--GFMEENQTKLSPRELTALREKLHQA------ 2141
Query: 1538 FLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSG-DVKVEEKIVAERQ 1596
++Q + LQE + + K+L+E+ TS + E+ A+
Sbjct: 2142 -----------------KEQYEALQEETRV----AQKELEEAVTSALQQETEKSKAAKEL 2180
Query: 1597 QEYKEKLQGICDLLT-------QTENRLIGHQE---------AFMIGDGTVELKKYQSKQ 1640
E K+K+ + D +T Q L G ++ A DG + + + K
Sbjct: 2181 AENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKL 2240
Query: 1641 EELQKDMQGSAQALAEVVKN-------TENFLKENGEKLSQEDKALIEQKLNEAKIKCEQ 1693
++ + M+ Q L +N + FL ++G L+ E++ +++QKL E K EQ
Sbjct: 2241 DKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELK---EQ 2297
Query: 1694 LNLKAEQSKKELDKVVTTAIKEETEKVAAVKQ-----LEESKTKIENLLDWLSN---VDK 1745
+ QS+ EL +V T +++E +K + LE S+ ++EN+ S+ +
Sbjct: 2298 YSTSLAQSEAELKQVQT--LQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPS 2355
Query: 1746 DSERAGTKHKQVIEQNG-THFQEGDGKSAI--------GEEDEVNGNLLETDVDG----- 1791
+R G+ + VI G F G+ + G+E GNL++ +
Sbjct: 2356 LLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATERY 2415
Query: 1792 ----------------------QVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQ 1829
Q + ++L Q +A EK++S A Q
Sbjct: 2416 TALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQ 2475
Query: 1830 VLLEKQGQYLSPEEK---EKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADY 1886
+ KQ Q E + EKLQK +++ + + T S+ +
Sbjct: 2476 LATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSL 2535
Query: 1887 TEFEHWLQ----QSEQELENLEAGADDINGLMTKL--KRQKSFSEDVISH----KGDLRY 1936
E LQ QS+ E+LE+ I + L K+ S S VI L+
Sbjct: 2536 AERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQ 2595
Query: 1937 ITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDL 1996
LEA + R D S T +Q KL + RF L + ++LK L
Sbjct: 2596 DIARQKSSLEATREMVTRFMETAD-STTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKL 2654
Query: 1997 VDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVA 2056
+ + + +E S LQ S+ L+ D +++ ++ + L ++ QQ
Sbjct: 2655 LPQAEMFEHLS----GKLQQFMENKSRMLASGNQPD-QDITHFFQQIQELNLEMEDQQEN 2709
Query: 2057 VEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSV 2116
++ L+ L +L ++ Q + ++ + +L K+V ER + + S
Sbjct: 2710 LDTLEHLVTELSSCGFALDLCQH--QDRVQNLRKDFTELQKTVKEREKD-------ASSC 2760
Query: 2117 QDGLDEMLDWMGNVESSLKE-QGQVPLNSTA----------------LQDIISKNIMLEQ 2159
Q+ LDE + + LKE +G +P T+ L D SK ++E+
Sbjct: 2761 QEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEE 2820
Query: 2160 DIAGRQSSINAMNE--------KVKKFMETTDPSTAS-----------SLQAKMKDLSAR 2200
S N + E K + + S S +Q M D++ +
Sbjct: 2821 INCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLK 2880
Query: 2201 FSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDV-TELSQY 2259
+ + E ++ + ++E + + +LE+K + L +D TE +
Sbjct: 2881 YEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKA 2940
Query: 2260 MQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKE 2319
ES FL + +KE + GL LV + ++ +K++++ + + E
Sbjct: 2941 QAESNKAFLAELEQNSPKIQKVKEALA-GL-----LVTYPNSQEAENWKKIQEELNSRWE 2994
Query: 2320 AVTSC----QEQLD-------AFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDT 2368
T Q QL+ FQ L+ W+ E + ++ P + ++ +
Sbjct: 2995 RATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPL----SIDPNMLNA 3050
Query: 2369 KKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEF 2428
+K Q ++ LK E ++ + ++ ++ +L G G
Sbjct: 3051 QKQQVQFMLKEFEARRQQHEQLN------------------EAAQGILTGPGD------- 3085
Query: 2429 WANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMN- 2487
+ + ++K++ I+ + + L DK LN++ S++ +A +S+ + LQ ++
Sbjct: 3086 -VSLSTSQVQKELQSINQKWVE----LTDK---LNSRSSQIDQAIVKSTQYQELLQDLSE 3137
Query: 2488 KTATKWQ----QTPAPTDTEAVKTQVEQNKSFEAELKQ---NVNKVQELKDKLTELLEEN 2540
K Q Q+ T EAVK Q+E+ ++L+Q V + Q L D+L+ L+ E
Sbjct: 3138 KVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQ 3197
Query: 2541 PDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKEL 2600
E K+ L + Q L L DR +L+ + + QFQ + +L+ WL +K+
Sbjct: 3198 YLKDEL---KKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQS 3254
Query: 2601 MVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSR--PGEDPSLRG 2658
+ P+S L +Q Q+ + + YE + A G+ +L PGE+ +
Sbjct: 3255 QQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEE---KR 3311
Query: 2659 IVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLA 2718
++ QL + W+ L+ + +DR + + K+ +YQ + L + D K+ S L
Sbjct: 3312 TLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKM-SELR 3370
Query: 2719 VSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGIL 2778
V+ P + L ++ M E+++ + +++ + + L + + +GI
Sbjct: 3371 VTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADE---------DGIR 3421
Query: 2779 KSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQ-AWLDTKKEEQNKSHPISAKLDVLE 2837
+ Q + + LQ+ S + Q R+FQ ++ + +K+ + H + D L
Sbjct: 3422 DEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEI-FDALG 3480
Query: 2838 SLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQ--------GSEKAALQLQLNTIKTN 2889
S +K+ K L AQ + + + + L TQ GS+ + L Q +
Sbjct: 3481 SQACSNKNLEK-LRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQE 3539
Query: 2890 WDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIA 2949
+ +VK+R N + + ++E + + + + ++ D +G +I
Sbjct: 3540 F----LEVKQRVN------SGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIG 3589
Query: 2950 K-LKSLQKEMDQ---HFGMVELLNNTANSLLSVCE--IDKEVVTD------ENKSLIQKV 2997
+ SLQ +++ + +L + + C +++E D E ++L ++
Sbjct: 3590 RDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQC 3649
Query: 2998 DMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQA--YSNKYL 3055
+TE+ +++ LE + ++F K A+E + +G++ + +
Sbjct: 3650 GKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLA 3709
Query: 3056 TMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDE 3115
Q++ + L+ ++ L Q L+ A + +E I +TL+++V +
Sbjct: 3710 DFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQ 3769
Query: 3116 KCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKL 3175
+ + L+ L G FQ+ + + S A+ ++ + + P + + ++ Q + K + L
Sbjct: 3770 RIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLL 3829
Query: 3176 EALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIK 3235
+ A+ D + + E + D I LE+L + +LL +A AR++Q+E +
Sbjct: 3830 DDRKATVDMLQAEGGRIAQSAELA-DREKITGQLESLESRWTELLSKAAARQKQLEDILV 3888
Query: 3236 RLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQD 3295
++F+ + S L E+ + PVG +T I QQ+ K + E+IE
Sbjct: 3889 LAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALE-EDIENHATDVHQ 3947
Query: 3296 VNWLGQGLIQSAAKSTSTQG-LEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDA 3354
+GQ L S+ S + QG L +D + AR+ + + ++AA L +AL + F +
Sbjct: 3948 AVKIGQSL--SSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGED 4005
Query: 3355 LESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIA 3414
+L+W+ + E+ +++ + V+ Q + L + +RK V+ + G+ +
Sbjct: 4006 EVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALL 4065
Query: 3415 TTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTI 3474
+ + I ++L + +R+ + + R LE +A +F T E L WL +
Sbjct: 4066 KQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREV 4125
Query: 3475 EKRLVNC---EPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDK 3531
E+ L P G Q + ++ + K L+ +++ H L + ++L L +
Sbjct: 4126 EEELATSGGQSPTGEQIPQFQQ---RQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAR 4182
Query: 3532 DMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLS 3591
+ + + + Y + + R + + A+ ++ + + + W+ E KL L
Sbjct: 4183 EGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALG 4242
Query: 3592 VQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIK 3651
+ Q + DI+ K ++D+ + E+ ++ ++Q+K E++
Sbjct: 4243 PIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLI 4302
Query: 3652 ARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQ 3711
+Y+ I+ L+++ LE+A L + T+EEL W+++ + + + E+ Q
Sbjct: 4303 QQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQ 4362
Query: 3712 AQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTIT 3771
Q ++L++ +K +D L ++ L EL P E +E+ + Y + + +
Sbjct: 4363 QQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNP-EEGEMVEEKYQKAENMYAQIKEEVR 4421
Query: 3772 QKVEEIDAAILRSQQ---FDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTF 3828
Q+ +D A+ +S Q F + L + +L I E D+ + K+
Sbjct: 4422 QRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSA 4481
Query: 3829 TMEILRHKDIIDDLVKSGHKIMTACSEEEK----QSMKKKLDKVLKNYDTICQINSERYL 3884
T+E+ + + + L + G +++ +K + ++ KLD+++ ++ I ER +
Sbjct: 4482 TVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREI 4541
Query: 3885 QLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEH 3944
+ L +FW L + +TQ I+ L +P ++ ++QQ E ++E
Sbjct: 4542 KFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGL 4601
Query: 3945 KPHIDKMNKTGPQLL-ELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQ 4003
++ + G L+ E +++ + + + + K+R L++A+ + Q
Sbjct: 4602 HEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQ 4661
Query: 4004 FHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRG 4063
+ D + + + L+ V +L P + ++ +K+Q++E K V++ + Q E L +G
Sbjct: 4662 YQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQG 4721
Query: 4064 EEMIAR-SGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHM 4122
E M+ + + TD+DI +++ L ++ +WEN+ + R+ KL + +F
Sbjct: 4722 ELMLKKATDETDRDI----IREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALE 4777
Query: 4123 SLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAA 4182
L+ + T++ + DP V++ + ++ ++ Q ++ V G+EL+ +
Sbjct: 4778 ELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLES 4837
Query: 4183 CGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGG 4242
D ++ ++ +N W+S+ + ++R +L+ +Q A + ++ +
Sbjct: 4838 SAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMES 4897
Query: 4243 KLASMSPIGTDLETVKQQIE-------ELKQFKSEAYQQQIEMERLNHQAELLLKKVTEE 4295
+L++ P G ET ++Q++ +LK K E Y Q ++ RL +LL +
Sbjct: 4898 QLSASKPTGGLPETAREQLDTHMELYSQLKA-KEETYNQLLDKGRL-----MLLSRDDSG 4951
Query: 4296 SDKHTVQD-PLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLL 4354
S T Q L+E K W + ++ R+ KLE AL +FQ++L E + WLT E L
Sbjct: 4952 SGSKTEQSVALLEQK--WHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSL 5009
Query: 4355 SEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKL 4414
+ P + ++ +H V N+V AH+ + +++ GN L S ++ ++N L
Sbjct: 5010 NIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLL 5069
Query: 4415 EVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPE 4474
+ RW+ V++++ +R + LD A ++AK FH + L WL D E HL + + P+
Sbjct: 5070 VSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPD 5129
Query: 4475 TAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLAR--CPKSAETNIDQDINNLKEKWES 4532
K QL+ H E K+ Y + ++ G+ + + P+ ++ +D + +++KW++
Sbjct: 5130 KIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQ-KLDNFLGEVRDKWDT 5188
Query: 4533 VETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEH 4592
V K ER+ KLEEAL + +F ++LQ ++WL + E L LD V+ +D H
Sbjct: 5189 VCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAH 5248
Query: 4593 KVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRS 4652
KVF E+ + L ++G L + + D +K L + +RW+ V + V +
Sbjct: 5249 KVFQKELGKRTGTVQVLKRSGREL-IENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSR 5307
Query: 4653 LDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKH 4712
L+ A K+A+ F + L+EWL E+E++L + +D + +++ + HKEF K + K
Sbjct: 5308 LEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKVEEKR 5367
Query: 4713 SVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQ 4772
++ G + D + ++ +R +++ + + + Q +LE AL
Sbjct: 5368 VDVNSAVAMGEVIL-AVCHPDCITTIKHWITIIRARFEEVLTWAKQHQQRLETALSELVA 5426
Query: 4773 FTDALQALIDWLYRVEPQL--AEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKR 4830
+ L+ L+ W+ E L + +P+ +ID V LI H+ F +E+ ++ V + +
Sbjct: 5427 NAELLEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRVTK 5486
Query: 4831 SARE---------LIEGSR------------------DDSSWVKVQMQELSTRWETVCAL 4863
+ + IE SR S ++ +LS RW+ V L
Sbjct: 5487 TYKRKNIEPTHAPFIEKSRSGGRKSLSQPTPPPMPILSQSEAKNPRINQLSARWQQVWLL 5546
Query: 4864 SISKQTRLEAALRQAEE 4880
++ +Q +L AL + EE
Sbjct: 5547 ALERQRKLNDALDRLEE 5563
Score = 464 bits (1195), Expect = e-130
Identities = 690/3701 (18%), Positives = 1500/3701 (40%), Gaps = 386/3701 (10%)
Query: 625 RKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQL----DRTEWG---------SDL 671
++ L+K+ QN +++ +DL +WV + + L RT SDL
Sbjct: 2040 QEALVKTLQKQQNTCHQQL-----EDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDL 2094
Query: 672 PSVESHLENHK-NVHRAIEEFESSLKE--AKISEIQMTAPLKLTYAEKLHRLESQYAKLL 728
++ ++N + +++ E ++E K+S ++TA EKLH+ + QY L
Sbjct: 2095 KDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRELTA-----LREKLHQAKEQYEALQ 2149
Query: 729 NTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMREL 788
+R ++ L+ V+ A + E E+ + A + +E I D+ +
Sbjct: 2150 EETRVAQKELE---EAVTSALQQ-----ETEKSKAAKELAENKKKIDALLDWVTSVGSSG 2201
Query: 789 DQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYF 848
Q N+ +++++ L + A T + Y Q Q C+ ++ +E +
Sbjct: 2202 GQLLTNLPGMEQLSGASLEKG--ALDTTDGYMGVNQAPEKLDKQ-CEMMKARHQELLSQQ 2258
Query: 849 EFF----------------NDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESME 892
+ F N E L+ ++ +YS + S +L+ VQ +
Sbjct: 2259 QNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQ-VQTLQD 2317
Query: 893 EKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECV 952
E ++ LQ + + +++ ++ + P +K + + I
Sbjct: 2318 ELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVI--------- 2368
Query: 953 LANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNV---LTLWHE- 1008
SH+ + ++ +G + + F KE ++ N ++ + ++ T H
Sbjct: 2369 ----SHKGDLRFVTISGQKVLDMENSF---KEGKEPSEIGNLVKDKLKDATERYTALHSK 2421
Query: 1009 -----SHINMKSVVSWHYLINEIDRIRA---SNVASIKTML-------PGEHQQVLSNLQ 1053
SH+NM + +H N D ++A + A+++ +L PG Q+ L+ +
Sbjct: 2422 CTRLGSHLNM-LLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTK 2480
Query: 1054 SRFEDFLEDSQESQVFS--GSDITQLEKEVNVCKQYYQELLKS------------AEREE 1099
E+ E + DI ++E E ++ QE S AER
Sbjct: 2481 QLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSS 2540
Query: 1100 -------QEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKL 1152
Q +SV S +++I +N E + + + + + ++ L ++ KL
Sbjct: 2541 LLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNM-------KL 2593
Query: 1153 KKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLK 1212
K+++ R K L T + F + A S++ L+ +L V Q Q+ +K
Sbjct: 2594 KQDIARQKSSL-EATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQ---EKES 2649
Query: 1213 TVNLVLKNTQAAEALVKLYETKLCEEEAVIADKN----NIENLISTLKQWRSEVDEKRQV 1268
++ +L + E L + + + ++A N +I + +++ E++++++
Sbjct: 2650 SLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQEN 2709
Query: 1269 FHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGI 1328
LE + + + LD H+++ L + + + + R +D
Sbjct: 2710 LDTLEHLVTELSSCGFA---------LDLCQHQDRVQNLRKDFTELQKTVKEREKDASSC 2760
Query: 1329 GKSLKYYRDTYHPLDDWIQQVE--------TTQRKIQENQPENSKTLATQLNQQKMLVSE 1380
+ L +R W+++ E + K E Q E+ K+L + LV E
Sbjct: 2761 QEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEE 2820
Query: 1381 IEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEF 1440
I K + ++ T D + +T + V S S V I +
Sbjct: 2821 INCKGTSLENL-----IMEITAPDSQGKTGSILPSVGSSVGS-VNGYHTCKDLTEIQCDM 2874
Query: 1441 MDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEE-----EKKEHVEKAKELQKWVSN 1495
D+ +Y L ++ + + L R+EE K E KE V K+ + +
Sbjct: 2875 SDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTK 2934
Query: 1496 ISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELE 1555
++T+K ++ K ++ + +S +I KE L+ L T K EE N
Sbjct: 2935 -TETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRW 2993
Query: 1556 KQVKTLQESYNLLFSESLK-----QLQESQ-------------TSGDVKVEEKIVAERQQ 1597
++ + + ES Q ESQ G + ++ ++ ++Q
Sbjct: 2994 ERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQ 3053
Query: 1598 EYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEV 1657
+ + L+ + Q +L + + G G V L Q +QK++Q Q E+
Sbjct: 3054 QVQFMLKEF-EARRQQHEQLNEAAQGILTGPGDVSLSTSQ-----VQKELQSINQKWVEL 3107
Query: 1658 VKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTT---AIK 1714
+ + SQ D+A+++ + ++ ++A + + ++T A+K
Sbjct: 3108 TDKLNS-------RSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVK 3160
Query: 1715 EETEKVAAVK----QLEESKTKIENLLDWLSNV-------DKDSERAGT----------- 1752
++ E+ + ++ QL+ + + L D LS + D+ +R T
Sbjct: 3161 QQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDL 3220
Query: 1753 -----KHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENL--NQQYQ 1805
Q + FQ+ + +D+ + + ++ Q L N+++Q
Sbjct: 3221 AADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQ 3280
Query: 1806 KVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAES 1865
K QH S VI+A + +L G EEK LQ + ELK H+E ++
Sbjct: 3281 KSLNQH----SGSYEVIVAEGESLLLSVPPG-----EEKRTLQNQLVELKNHWEELSKKT 3331
Query: 1866 EKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSE 1925
+ ++ +K+ + W++ + ++ L D + L + L R K+
Sbjct: 3332 ADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQ-LESSLLRSKAMLN 3390
Query: 1926 DVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSK 1985
+V + L + + + ++ +++ + DG + + + + + +D T+ ++
Sbjct: 3391 EVEKRRSLLEILNSAADILINSSE--ADEDGIRDEKAG----INQNMDAVTEELQAKTGS 3444
Query: 1986 CNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKA 2045
+ L++ + +++ E G L+ +A S+ S + + L+ Q E +A
Sbjct: 3445 LEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNK---NLEKLRAQQEVLQA 3501
Query: 2046 LQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEK 2105
L+ Q+ + + L + A DA L A+ Q+ L ++ + VN
Sbjct: 3502 LEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFL--------EVKQRVNSGCVM 3553
Query: 2106 LQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQ 2165
++ L + EM + +++ L G + ++ +LQ I + I +
Sbjct: 3554 MENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLK 3613
Query: 2166 SSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELF 2225
I A + + +E L+ +++ L+ + + + + K A+ E+L+ +
Sbjct: 3614 LDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGK---ARQEQLELTLGRV 3670
Query: 2226 ENLSEKLQTFLETKTQAL----------TEVDVPGKDVTELSQYMQESTSEFLEHKKHLE 2275
E+ KL+ + T A TEV++ + + + + +E + +
Sbjct: 3671 EDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVN 3730
Query: 2276 -----VLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDA 2330
++ S K+ GL D + + N L+KK + I + +EA+ C +
Sbjct: 3731 GLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKK---VAQRIAQLQEALLHCGK---- 3783
Query: 2331 FQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKS-LEDTKKLQEKWSLKTPEIQKVNNSG 2389
FQ ++ L SW+ +T + + +P + K+ +++ K LQ + + + G
Sbjct: 3784 FQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEG 3843
Query: 2390 ISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWAN--KGLTSIKKDMTDISHG 2447
+ SA + I G + E W + +K + DI
Sbjct: 3844 GRIAQ--SAELADREKIT------------GQLESLESRWTELLSKAAARQKQLEDI--- 3886
Query: 2448 YEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKT 2507
L+L + E +S E+ A P T T ++
Sbjct: 3887 -----LVLAKQFHETAEPISDFLSVTEKKLA---------------NSEPVGTQTAKIQQ 3926
Query: 2508 QVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLT 2567
Q+ ++K+ E +++ + V + K+ + L E + + + +++ E+
Sbjct: 3927 QIIRHKALEEDIENHATDVHQAV-KIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRC 3985
Query: 2568 IDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQ 2627
+ L+++ +N F E ++ WL E E +S + ++L+ Q L +
Sbjct: 3986 CRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNE 4045
Query: 2628 EFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQ 2687
E RK +Q GQ +L + + L +++E+L + ++ +T S ++Q
Sbjct: 4046 EIVNRKKNVDQAIKNGQALLKQTTGEEVL--LIQEKLDGIKTRYADITVTSSKALRTLEQ 4103
Query: 2688 AIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQI 2747
A +T++QS L+ L +++ +L++S S + + Q + +++K+E+ + + +
Sbjct: 4104 ARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVL 4163
Query: 2748 KVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQ 2807
+ L LV + L + + + +K V V + +A S Q++Q
Sbjct: 4164 DTVNEVSRALLELVPWR-AREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQ 4222
Query: 2808 MSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENL 2867
+ AW+ K + PI + D + ++ K FS + ++ + +
Sbjct: 4223 AADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEI 4282
Query: 2868 LLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDK 2927
+K LQ + ++ ++ + ER +L+ + ++ E E L PWI++
Sbjct: 4283 FGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEE 4342
Query: 2928 CQNNLEEIKF-CLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVV 2986
+ + ++ +D + +++ L++ + +H ++ L L + + E+V
Sbjct: 4343 TRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMV 4402
Query: 2987 TDENKSLIQKVDMVTEQLHSKKFCLE---NMTQKFKEFQEVSKESKRQLQCAKEQLDIH- 3042
++ + + E++ + L+ + + + EF + + L+ +L +
Sbjct: 4403 EEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPP 4462
Query: 3043 ------DSLGSQAYSNKYLTM-LQTQQKSLQALKHQ----VDLAKRLAQDLVVEASDSKG 3091
D + NK T+ L+ Q S +ALK + + ++ +DL +K
Sbjct: 4463 LIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLA-----AKE 4517
Query: 3092 TSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSM 3151
D L Q+ ++ +++ + K FL+ L+ F + + + + D + +
Sbjct: 4518 IQDKLDQMVFFWEDIKARAEEREIK--FLDV-LELAEKFWYDMAALLTTIKDTQDIVHDL 4574
Query: 3152 APVGRDAETLQKQKETIKAFLKKLEALMASNDNAN-KTCKMMLATEETSPDLVGIKRDLE 3210
G D +++Q E + ++ + L + ++ A ET + +++ ++
Sbjct: 4575 ESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGET--EKPEVRKSID 4632
Query: 3211 ALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETET 3270
++ L + R E++E ++ ++ L+ L + PVG + T
Sbjct: 4633 EMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNT 4692
Query: 3271 INQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTL 3330
+ QLN K F K E+ Q + + +N G+ +++ A T + L ++ W+ L
Sbjct: 4693 VKDQLNEMKEF-KVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENL 4751
Query: 3331 NKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQK 3390
+K+A R +L+ ALL G+FQ ALE L+SW+ TEEL+ Q+P S + KV++ ++ +
Sbjct: 4752 GEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHH 4811
Query: 3391 LLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQL 3450
+L+ + ++TVE + + G ++ ++ D + +L ++ WE++L K E R +QL
Sbjct: 4812 VLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQL 4871
Query: 3451 EGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNK 3510
+ AQ FH +E LT +E +L +P G EQ+ H L + +
Sbjct: 4872 QSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEE 4931
Query: 3511 HLHQAVSIGQSLKVLSSRED----KDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNA 3566
+Q + G+ + L SR+D QS Q W++ + K R L++AL A
Sbjct: 4932 TYNQLLDKGRLM--LLSRDDSGSGSKTEQSVALLEQKWHV-VSSKMEERKSKLEEALNLA 4988
Query: 3567 KIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALL 3626
F E +NWL L+ S + Q E +V ++ + + +
Sbjct: 4989 TEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQ 5048
Query: 3627 NGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELC 3686
G +L + +V++I++ L ++++R++ + + S + ++L+ A + A++ H ++L
Sbjct: 5049 TGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLI 5108
Query: 3687 TWLDKVEVELLSYETQVLKGEEASQAQM-RPKELKKEAKNNKALLDSLNEVSSALLE--L 3743
WL+ E L S E ++ + + Q+ + KE +K + + D+ AL E L
Sbjct: 5109 DWLEDAESHLDS-ELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTL 5167
Query: 3744 VPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEK 3803
+P +++ L+ + E +++ V ++ +++ A+L S QF A A + W+ + E
Sbjct: 5168 LPEDSQK-LDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEP 5226
Query: 3804 KLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKK 3863
+L + + D + K F E+ + + L +SG +++ S ++ +K
Sbjct: 5227 QLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIEN-SRDDTTWVKG 5285
Query: 3864 KLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALE 3923
+L ++ +DT+C+++ + +LE+A F +T L WL+E + + A +
Sbjct: 5286 QLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDD 5345
Query: 3924 YETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAA-----DT 3978
E L+ + H++ + + E + ++ G +L + + + + ++ +
Sbjct: 5346 TEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITIIRARFEE 5405
Query: 3979 LYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQ 4038
+ + K+ ++ AL E ++ + + + I + +++R ++P I ++++K
Sbjct: 5406 VLTWAKQHQQRLETALSELVANAELLEELLAWIQWAETTLIQRDQEP--IPQNIDRVKAL 5463
Query: 4039 ISENKNVSVDMEKLQP----LYETLKQRGEEMI-------ARSGGTDKDIS--------- 4078
I+E++ +M + QP + +T K++ E +RSGG K +S
Sbjct: 5464 IAEHQTFMEEMTRKQPDVDRVTKTYKRKNIEPTHAPFIEKSRSGGR-KSLSQPTPPPMPI 5522
Query: 4079 ---AKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEK 4116
++A +++Q+ W+ + L ER+ KL D ++ E+
Sbjct: 5523 LSQSEAKNPRINQLSARWQQVWLLALERQRKLNDALDRLEE 5563
Score = 420 bits (1080), Expect = e-116
Identities = 582/3160 (18%), Positives = 1263/3160 (39%), Gaps = 295/3160 (9%)
Query: 2107 QITLTRSLSVQ--DGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGR 2164
Q TR L ++ + L L + N+E K+ + LN LQD++ + +LE+++
Sbjct: 1795 QNVFTRQLCLEHDEKLVSYLSLLRNIEMRTKQIQPLELNLAELQDLLCQAKVLERELKDL 1854
Query: 2165 QSSINAMNEKVKKFM----ETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEEL-- 2218
+ ++ E V + + + +L+ K+L S S L +
Sbjct: 1855 TTLVSQELECVNQIIISQPQEVPAQLLKALEKDAKNLQKSLSSVSDTWNSRLLHFQNAVE 1914
Query: 2219 --KTKV----ELFENLSEKLQTFLETKTQAL------TEVDVPGKDVTELSQYMQESTSE 2266
KTKV E + L+ ++ K L +E+DV ++ L QY ++
Sbjct: 1915 IEKTKVLNQHTQLEGRLQDLRAWVGNKNLILNSKGSNSEIDVDSLNLC-LQQY-EDLKQP 1972
Query: 2267 FLEHKKHLEVL----HSLLKEISSHGLPSDKALVLEKTNNLSKKFKE-MEDTI------- 2314
E K L+ L + E + P +L N L + F++ +E T
Sbjct: 1973 MAERKAQLDALAFDIQFFISEHAQDLSPQQNRQMLRLLNELQRSFQDILEQTAAQVDALQ 2032
Query: 2315 -----KEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLG---KSLE 2366
E++ V + Q+Q + ++ L SW+ + + + Q +DL K+
Sbjct: 2033 GHLQQMEQEALVKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQS 2092
Query: 2367 DTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTE 2426
D K LQ+ + N S ++ + EG +
Sbjct: 2093 DLKDLQD----------DIQNRATSFATVVKDI-------------------EGFMEENQ 2123
Query: 2427 EFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKL-SKLQKAQEES--------- 2476
+ + LT++++ + YE L + EL + S LQ+ E+S
Sbjct: 2124 TKLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAEN 2183
Query: 2477 ----SAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDK 2532
A++ W+ + + + T P + +E+ + VN+ E DK
Sbjct: 2184 KKKIDALLDWVTSVGSSGGQ-LLTNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDK 2242
Query: 2533 LTELLEENPD------------TPEA------------PRWKQMLTEIDSKWQELNQLTI 2568
E+++ T A P +QML Q+L +L
Sbjct: 2243 QCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQ------QKLGELKE 2296
Query: 2569 DRQQKLEESSNNLTQFQTVEAQLKQ----------WLVEKELMVSVLGPLSIDPNMLNTQ 2618
L +S L Q QT++ +L++ WL E + + P L +
Sbjct: 2297 QYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSL 2356
Query: 2619 RQQVQILLQEFATRKPQYEQLTAAGQGILS-----RPGEDPS-LRGIVKEQLAAVTQKWD 2672
++ ++ + K +T +GQ +L + G++PS + +VK++L T+++
Sbjct: 2357 LKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATERYT 2416
Query: 2673 SLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLA--VSTHPDAMNQQL 2730
+L + + ++ + + Q+Q+ SL + + + L+ V++ P + +QL
Sbjct: 2417 ALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQL 2476
Query: 2731 ETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYL-KAELSRQLEGILKSFKDVEQKAE 2789
T +++++E+ + + ++ Q + D+ + E + + IL F+ +
Sbjct: 2477 ATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLA 2536
Query: 2790 NHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKT 2849
LQ A A S Q+ + ++ S V++ + + +
Sbjct: 2537 ERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQD 2596
Query: 2850 LTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLE 2909
+ Q E T + + A LQ +L + ++ Q +E+E+ LK+ L
Sbjct: 2597 IARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLP 2656
Query: 2910 KALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGE--NSIAKLKSLQKEMDQHFGMVEL 2967
+A E E L + + N + + + + + +++ L EM+ ++
Sbjct: 2657 QA----EMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDT 2712
Query: 2968 LNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKE 3027
L + LS C ++ +++ ++N+ + F E Q+ KE
Sbjct: 2713 LEHLVTE-LSSCGFALDLCQHQDR-------------------VQNLRKDFTELQKTVKE 2752
Query: 3028 SKRQLQCAKEQLDIHDSL--GSQAYSNKYLTMLQTQQKSLQA--LKHQVDLAKRLAQD-- 3081
++ +EQLD L Q + + + + S+ A L+ Q++ K L D
Sbjct: 2753 REKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWA 2812
Query: 3082 ---LVVEASDSKGTSDVLLQVETIAQE---------------------HSTLSQQVDEKC 3117
+VE + KGTS L +E A + + T + +C
Sbjct: 2813 SKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQC 2872
Query: 3118 SFLET-----KLQGIGH-FQNTIREMFSQFAEFDDE-----------------LDSMAPV 3154
+ KL G+ H Q +++ + ++ E E +D+M+
Sbjct: 2873 DMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSP 2932
Query: 3155 GRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSK 3214
+ ET++ Q E+ KAFL +LE + +L T S + K+ E L+
Sbjct: 2933 TK-TETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNS 2991
Query: 3215 QCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQ 3274
+ + + AR+ Q+E + L F + + L + E GP+ ++ +N Q
Sbjct: 2992 RWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQ 3051
Query: 3275 LNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAK-STSTQGLEHDLDDVNARWKTLNKK 3333
+ F +E E + + + +N QG++ S ST ++ +L +N +W L K
Sbjct: 3052 KQQVQ-FMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDK 3110
Query: 3334 VAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQ 3393
+ R++Q+ +A++ ++Q+ L+ L + + ++ Q S + + VK Q++E ++
Sbjct: 3111 LNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIR 3170
Query: 3394 RLLDDRKSTVEVIKREGEKIAT-TAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEG 3452
L+ V+ + ++++ E K ++ K+L + + L + A R +L+
Sbjct: 3171 SDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQA 3230
Query: 3453 ISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHL 3512
QQF + + L WL + + PI + +L+ Q+ +++ + + H+
Sbjct: 3231 ALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSY 3290
Query: 3513 HQAVSIGQSLKV-LSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGE 3571
V+ G+SL + + E+K +Q++L + + E+ +K+ R L+ + A+ +
Sbjct: 3291 EVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQW 3350
Query: 3572 DEVELMNWLNEVHDKLSKLSV-------------QDYSTEGLWKQQSELRVLQE--DILL 3616
+L+ W+ + K+S+L V + K++S L +L DIL+
Sbjct: 3351 HVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILI 3410
Query: 3617 RKQNVDQALLN----GLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQAL 3672
D+ + G+ +E+ LE + R ++ + ++ K +E A
Sbjct: 3411 NSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAK 3470
Query: 3673 QLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMR--PKELKKEAKNNKALL 3730
+ + C+ +E L + +VL+ E +R + L ++A +
Sbjct: 3471 HQLEIFDALGSQACS---NKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDAS 3527
Query: 3731 DSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQA 3790
L++ A E + + R ++ E+ K+E I QF
Sbjct: 3528 QLLHQAEVAQQEFLEVKQRVNSGCVMMEN-------------KLEGIG-------QFHCR 3567
Query: 3791 ADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIM 3850
S + + + +L +G I + D +Q++ + F +I K I+ ++
Sbjct: 3568 VREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHML 3627
Query: 3851 TACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTET 3910
+ +K++L+ + K + + R QLE V F+ + L T
Sbjct: 3628 EEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAA 3687
Query: 3911 QSIISQLPAPALEYETLRQQQEEHRQL-RELIAEHKPHIDKMNKTGPQLLELSPGEGFSI 3969
+ + E E + QQ + + +E + + + ++N G L++ S G+ +
Sbjct: 3688 EEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQ-SAGKDCDV 3746
Query: 3970 Q---EKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPP 4026
Q + ++ + + V +R L EA+ +F D ++ +L L E +
Sbjct: 3747 QGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQK 3806
Query: 4027 SISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKL 4086
SAE + +K QI E K + ++ + + L+ G + + D++ + +L
Sbjct: 3807 PPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADRE----KITGQL 3862
Query: 4087 DQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPS 4146
+ + W + + R+ +L D++ LA++F + + T+ + + E G +
Sbjct: 3863 ESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTA 3922
Query: 4147 VVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLN 4206
++QQ + + E+I+ ++ + +G L + ++ ++ + ID L + + +
Sbjct: 3923 KIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQ 3982
Query: 4207 KAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQ 4266
+ L++A+ A + + V +W+ KL+S+ + + +Q +
Sbjct: 3983 DRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLA 4042
Query: 4267 FKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKL 4326
E ++ +++ + LLK+ T E + +Q+ L +K + + L
Sbjct: 4043 LNEEIVNRKKNVDQAIKNGQALLKQTTGE-EVLLIQEKLDGIKTRYADITVTSSKALRTL 4101
Query: 4327 EGALLALGQFQHALDELLAWLTHTEGLLSE---QKPVGGDPKAIEIELAKHHVLQNDVLA 4383
E A +FQ +EL WL E L+ Q P G + I + L+ +V+
Sbjct: 4102 EQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTG---EQIPQFQQRQKELKKEVME 4158
Query: 4384 HQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAK 4443
H+ ++ VN+ L+E L + N++++ V + QR ++D A+++++
Sbjct: 4159 HRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQ 4218
Query: 4444 GFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQK 4503
+ + W+ +T+R L+A P+ + QL V +++ L
Sbjct: 4219 QYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSH 4278
Query: 4504 GQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFIN 4563
++ C + +T + + +L +++E++ +ER +LE A L +F + ++
Sbjct: 4279 RSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSP 4338
Query: 4564 WLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQ 4623
W+ + + P++ + + Q +E + + H+ I +L K G LK + ++
Sbjct: 4339 WIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEE 4398
Query: 4624 DVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQ---FHEAWSKLMEWLEESEKS 4680
+++ ++ + ++ + + +R +LD+A ++ Q FH+ ++E LE
Sbjct: 4399 G-EMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSR 4457
Query: 4681 LDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNL---K 4737
L I + DKI+ ++ +K L ++ R G L ++ AD +L +
Sbjct: 4458 LRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKE 4517
Query: 4738 LDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPV 4797
+ D L ++ W+ I ++ ER+ K + L + +F + AL+ + + + + +
Sbjct: 4518 IQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESP 4577
Query: 4798 HGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEG-SRDDSSWVKVQMQELSTR 4856
D ++ ++ + ++E ++ ++ +LI + V+ + E++
Sbjct: 4578 GIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNA 4637
Query: 4857 WETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLI 4916
WE + + +LE A++ A ++ + A+ +WL L + D + ++ +
Sbjct: 4638 WENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQL 4697
Query: 4917 DQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDS-ITTIKHWITIIRARFEEVLAWAKQ 4975
++ KEF ++ +++ E+ K G+ +L ++ I+ +T ++ +E +
Sbjct: 4698 NEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAH 4757
Query: 4976 HQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFME 5035
Q +L AL L Q LE L++WL E L + I + + ++ +A+H
Sbjct: 4758 RQHKLEGALLALGQFQHALEELMSWLTHTEELL--DAQRPISGDPKVIEVELAKHHVLKN 4815
Query: 5036 EMTRKQPDVDKVTKT-----YKRRAADPSSLQSHIPVLDK 5070
++ Q V+ V K D SSL+S + +++
Sbjct: 4816 DVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQ 4855
Score = 40.0 bits (92), Expect = 0.064
Identities = 37/141 (26%), Positives = 63/141 (44%), Gaps = 29/141 (20%)
Query: 319 MVNYLIQWIRHHVTTMSERT---FPNNPVELKALYNQYLQFKETEIPPKETEKSKIKRLY 375
++ L+ WI+ TT+ +R P N +KAL ++ F E E+ K+ + ++ + Y
Sbjct: 5430 LLEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFME-EMTRKQPDVDRVTKTY 5488
Query: 376 KLLEI------WIEF----GRIKLLQGYHP---------------NDIEKEWGKLIIAML 410
K I +IE GR L Q P N + W ++ + L
Sbjct: 5489 KRKNIEPTHAPFIEKSRSGGRKSLSQPTPPPMPILSQSEAKNPRINQLSARWQQVWLLAL 5548
Query: 411 EREKALRPEVERLEMLQQIAN 431
ER++ L ++RLE L++ AN
Sbjct: 5549 ERQRKLNDALDRLEELKEFAN 5569
>gi|20357504 dystonin isoform 1eB precursor [Homo sapiens]
Length = 3062
Score = 2291 bits (5938), Expect = 0.0
Identities = 1169/1170 (99%), Positives = 1170/1170 (100%)
Query: 422 RLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLL 481
RLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLL
Sbjct: 56 RLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLL 115
Query: 482 RQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISG 541
RQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISG
Sbjct: 116 RQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISG 175
Query: 542 ITQSLNSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPS 601
ITQSLNSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPS
Sbjct: 176 ITQSLNSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPS 235
Query: 602 GLVPNFSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQ 661
GLVPNFSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQ
Sbjct: 236 GLVPNFSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQ 295
Query: 662 LDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLE 721
LDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLE
Sbjct: 296 LDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLE 355
Query: 722 SQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYH 781
SQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYH
Sbjct: 356 SQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYH 415
Query: 782 AELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHI 841
AELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHI
Sbjct: 416 AELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHI 475
Query: 842 KENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYK 901
KENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYK
Sbjct: 476 KENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYK 535
Query: 902 STIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAK 961
STIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAK
Sbjct: 536 STIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAK 595
Query: 962 WKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHY 1021
WKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHY
Sbjct: 596 WKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHY 655
Query: 1022 LINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEV 1081
LINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEV
Sbjct: 656 LINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEV 715
Query: 1082 NVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHE 1141
NVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHE
Sbjct: 716 NVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHE 775
Query: 1142 SVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVY 1201
SVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVY
Sbjct: 776 SVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVY 835
Query: 1202 SMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSE 1261
SMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSE
Sbjct: 836 SMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSE 895
Query: 1262 VDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNR 1321
VDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNR
Sbjct: 896 VDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNR 955
Query: 1322 LRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEI 1381
LRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEI
Sbjct: 956 LRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEI 1015
Query: 1382 EMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFM 1441
EMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFM
Sbjct: 1016 EMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFM 1075
Query: 1442 DLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLK 1501
DLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLK
Sbjct: 1076 DLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLK 1135
Query: 1502 DAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTL 1561
DAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTL
Sbjct: 1136 DAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTL 1195
Query: 1562 QESYNLLFSESLKQLQESQTSGDVKVEEKI 1591
QESYNLLFSESLKQLQESQTSGDVKVEEK+
Sbjct: 1196 QESYNLLFSESLKQLQESQTSGDVKVEEKL 1225
Score = 62.8 bits (151), Expect = 9e-09
Identities = 201/1034 (19%), Positives = 407/1034 (39%), Gaps = 152/1034 (14%)
Query: 3555 RSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDI 3614
+S LL Q L +I + +L+NW++E+ +L + W S+L + E
Sbjct: 264 KSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTE---------WG--SDLPSV-ESH 311
Query: 3615 LLRKQNVDQALLNGLELLKQTTGDEV-------LIIQDKLEAIKARYKDITKLSTDVAKT 3667
L +NV +A+ LK+ E+ L +KL ++++Y + S + +
Sbjct: 312 LENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERH 371
Query: 3668 LEQALQLARRLHSTHEELCTWLDKVEVELLSYE-----TQVLKGEEASQAQMRPKELKKE 3722
L+ R +T+E + WL++ E E ++Y+ T + + ++ MR EL ++
Sbjct: 372 LDTLHNFVSR--ATNELI--WLNEKEEEEVAYDWSERNTNIARKKDYHAELMR--ELDQK 425
Query: 3723 AKNNKALLDS----LNEVSSALLELVPWRAR------------EGLEKMVAEDNERYRLV 3766
+N K++ + L E A L + +RA + +E+ + E+ +
Sbjct: 426 EENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFF 485
Query: 3767 SDT--ITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQV 3824
+D T + + AI R D+++ + + + ++ M + L+ T A L +
Sbjct: 486 NDAKEATDYLRNLKDAIQRKYSCDRSSS--IHKLEDLVQESMEEKEELLQYKSTIANL-M 542
Query: 3825 QKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDK-VLKN------YDTICQ 3877
K T+ L+ ++ D +K+ I C + + K D+ VL N + I
Sbjct: 543 GKAKTIIQLKPRNS-DCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISP 601
Query: 3878 INSERYLQL---------ERAQSLVNQFWETYEE-LWPWLTETQSIISQLPAPALEYETL 3927
+E + + A L N+ + Y+ L W ++ S + L E
Sbjct: 602 TGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEID 661
Query: 3928 RQQQEEHRQLRELI-AEHKPHIDKMNKTGPQLLELSP------GEGFSIQEKYVAADTLY 3980
R + ++ ++ EH+ + + LE S G + EK V +
Sbjct: 662 RIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEV---NVC 718
Query: 3981 SQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKE--- 4037
Q +++ K A ++ S + ++ I LE +RL + E + + E
Sbjct: 719 KQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVF 778
Query: 4038 QISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIH 4097
+I+E + + ++E+L+ T+ + EE +++ + S ++ +L+ ++ ++
Sbjct: 779 RITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASS---SVPTLRSELNVVLQNMNQVY 835
Query: 4098 TLVEEREAKLLDV-------------MELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGID 4144
++ KL V ++L E C+ ++I + ++ I
Sbjct: 836 SMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLI--------- 886
Query: 4145 PSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIV--KKSIDELNSAW 4202
S +KQ + + R+ L++EL + E+ E D K+ D+L W
Sbjct: 887 -STLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERW 945
Query: 4203 DSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDW---VDIAGGKLASMSPIGTDLETVKQ 4259
+++ +R+ LE ++ Y+D + DW V+ K+ P + +T+
Sbjct: 946 QNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQP--ENSKTLAT 1003
Query: 4260 QIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERI 4319
Q+ + K SE +Q +M+ AE V + + M + + DS ++
Sbjct: 1004 QLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKD------YELQTMTYRAMVDSQQKSP 1057
Query: 4320 INRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGD--------PKAIEIEL 4371
+ R+ A L + +F A +T L+++ GD K++E E
Sbjct: 1058 VKRRRMQSSADLIIQEFMDLRTRYTALVT----LMTQYIKFAGDSLKRLEEEEKSLEEEK 1113
Query: 4372 AKH----HVLQNDVLAHQSTVEAVNKAGNDLI--ESSAGEEASNLQNKLEVLNQRWQNVL 4425
+H LQ V T++ KAG + + EE S + +L Q Q L
Sbjct: 1114 KEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFL 1173
Query: 4426 EK-----TEQRKQQLDGALRQAKG-----FHGEIEDLQQWLTDTE---RHLLASKPLGGL 4472
K T++ + +L+ ++ + F ++ LQ+ T + L G +
Sbjct: 1174 AKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKLDKVIAGTI 1233
Query: 4473 PETAKEQLNVHMEV 4486
+T E L+V V
Sbjct: 1234 DQTTGEVLSVFQAV 1247
Score = 58.5 bits (140), Expect = 2e-07
Identities = 156/922 (16%), Positives = 365/922 (39%), Gaps = 121/922 (13%)
Query: 996 EQQYQNVLTLWHESHINMKSVVSWHY-LINEIDRIRASNVASIKTMLPGEHQQVLSNLQS 1054
E++ + V W E + N+ +H L+ E+D+ + N+ S++ + Q +L N +
Sbjct: 391 EKEEEEVAYDWSERNTNIARKKDYHAELMRELDQ-KEENIKSVQEIA---EQLLLENHPA 446
Query: 1055 RFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRN 1114
R + + + TQ + +C+ E+ +E + Y + ++ +
Sbjct: 447 RLT--------IEAYRAAMQTQWSWILQLCQ--------CVEQHIKENTAYFEFFNDAKE 490
Query: 1115 IRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFF 1174
L N +D + R+ +H+ + E + K+EL + K + + K +
Sbjct: 491 ATDYLRNLKDAIQRKYSCD-RSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTII 549
Query: 1175 SQAAASSSVPTLRS----------ELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAA 1224
+S P S ++ + + ++ ++++ K K ++
Sbjct: 550 QLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVIS-----PTGN 604
Query: 1225 EALVK--LYETKLCEEEAVIADKNNIENLISTLKQWR-SEVDEKRQV-FHALEDELQKAK 1280
EA+V + +EAV + + L W S ++ K V +H L +E+ + +
Sbjct: 605 EAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIR 664
Query: 1281 AISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRL----RDLEGIGKSLKYYR 1336
A + KT + H++ L R+++ D+ + K + +
Sbjct: 665 ASNVASIKTMLPGE-----HQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCK 719
Query: 1337 DTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQ-KYA 1395
Y L +++ +R+ QE N + +SE+ + +++ C+ +
Sbjct: 720 QYYQEL------LKSAEREEQEESVYN------------LYISEVRNIRLRLENCEDRLI 761
Query: 1396 EQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLII---QEFMDLRTRYTALVT 1452
Q ++ +L +R + Q+K + R++ I +EF +++ T
Sbjct: 762 RQIRTPLERDDLHESVFR--ITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPT 819
Query: 1453 LMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFS 1512
L ++ L + + + +++K K V+ + K + AE K +
Sbjct: 820 LRSE--------LNVVLQNMNQVYSMSSTYIDKLKT----VNLVLKNTQAAEALVKL-YE 866
Query: 1513 KQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSES 1572
+ E + K + + T++ + ++ DE+R LQ++ + E
Sbjct: 867 TKLCEEEAVIADKNNIENLISTLKQWRSE-----VDEKRQVFHALEDELQKA-KAISDEM 920
Query: 1573 LKQLQESQTSGDVKVEEKI-VAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTV 1631
K +E D E+ + ER Q ++ L L +++ + D +
Sbjct: 921 FKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWI 980
Query: 1632 ELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKC 1691
+ + ++ Q ++Q++ +++ LA + + + E K S+ D+ + A +K
Sbjct: 981 Q--QVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKD 1038
Query: 1692 EQLNLKAEQSKKELDKVVTTAIKEETEKVAA---VKQLEESKTKIENLLDWLSNVDK--- 1745
+L ++ +D + +K + +A +++ + +T+ L+ ++ K
Sbjct: 1039 YELQTMTYRAM--VDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAG 1096
Query: 1746 DS-ERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQY 1804
DS +R + K + E+ H ++ E + N+ +T D + +
Sbjct: 1097 DSLKRLEEEEKSLEEEKKEHVEKAK------ELQKWVSNISKTLKDAEKAG-----KPPF 1145
Query: 1805 QKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAE 1864
K K E+I ++ + + A Q+ Q+ L K G ++ EE+ +L+K +K L+ Y +E
Sbjct: 1146 SKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSE 1205
Query: 1865 SEKKMKLTHS-----LQEELEK 1881
S K+++ + + ++E+L+K
Sbjct: 1206 SLKQLQESQTSGDVKVEEKLDK 1227
Score = 56.6 bits (135), Expect = 7e-07
Identities = 189/951 (19%), Positives = 370/951 (38%), Gaps = 161/951 (16%)
Query: 4188 KPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASM 4247
KP++K S+ + N + +N + +Q + + D +Q D + G L S+
Sbjct: 260 KPLLKSSLLDQNLTEEEINMKF----------VQDLLNWVDEMQVQLDRTEW-GSDLPSV 308
Query: 4248 SPIGTDLETVKQQIEELKQFKSEAYQQQIEM------------ERLNHQ-AELLLKKVTE 4294
+ + V + IEE + EA +I+M RL Q A+LL +
Sbjct: 309 ESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQ 368
Query: 4295 ESDKHTVQDPLMEL--KLIW-DSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTE 4351
E T+ + + +LIW + EE + +A + HA EL+ L E
Sbjct: 369 ERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHA--ELMRELDQKE 426
Query: 4352 GLL------SEQKPVGGDPKAIEIEL------------------AKHHVLQNDVLAH--Q 4385
+ +EQ + P + IE + H+ +N
Sbjct: 427 ENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFN 486
Query: 4386 STVEAVNKAGN--DLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAK 4443
EA + N D I+ + S+ +KLE L Q E+ Q K + + +AK
Sbjct: 487 DAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAK 546
Query: 4444 GFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHM--EVCAAFEAKEETYKSLM 4501
+Q +++ L S P+ + + + ++ ++ E A + +K +
Sbjct: 547 TI------IQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVIS 600
Query: 4502 QKGQQMLA-----RCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHN 4556
G + + P + +D N +++++++V T +E ++ +
Sbjct: 601 PTGNEAMVPSVCFTVPPPNKEAVDL-ANRIEQQYQNVLTLWHESHINMKSVV-------- 651
Query: 4557 SLQDFINWLTQAEQTLNVASRPSLI--------------LDTVLFQIDEHKVFANEVNSH 4602
S IN + + + NVAS +++ + L E +VF+ +
Sbjct: 652 SWHYLINEIDRIRAS-NVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQ 710
Query: 4603 REQIIELDKTGTH--LKYFSQKQDVVLIKNLLIS----VQSRWEKVVQRLVERGRSLDDA 4656
E+ + + K LK +++ + NL IS ++ R E RL+ + R+
Sbjct: 711 LEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRT---- 766
Query: 4657 RKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYD 4716
HE+ ++ E ++ L ELE D + T + +EF A SV
Sbjct: 767 PLERDDLHESVFRITE-----QEKLKKELERLKDD--LGTITNKCEEFFSQAAASSSV-- 817
Query: 4717 TTNRTGRSLKEKTSLADDNL-KLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTD 4775
+L+ + ++ N+ ++ M S DK T+ ++ +N T
Sbjct: 818 ------PTLRSELNVVLQNMNQVYSMSSTYIDKLKTV---NLVLKN------------TQ 856
Query: 4776 ALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQAL------- 4828
A +AL+ LY E +L E++ V D + + NLI K ++ E+ ++ AL
Sbjct: 857 AAEALVK-LY--ETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKA 913
Query: 4829 KRSARELIEGSRD---DSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVV 4885
K + E+ + ++ D W K + +L RW+ V ++ LE + + +
Sbjct: 914 KAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTY 973
Query: 4886 HALLEWLAEAEQTLR-FHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVL 4944
H L +W+ + E T R P++ L T ++Q K + ++E K++++++ +
Sbjct: 974 HPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYS 1033
Query: 4945 AICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWA 5004
A + T+ + + + V ++R + A LI QE ++ +
Sbjct: 1034 ATVKDYELQTMTYRAMVDSQQKSPV-------KRRRMQSSADLII-QEFMDLRTRYTALV 1085
Query: 5005 ETTLTDKDK---EVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYK 5052
T +T K + + + EE K+L E + +E+ Q V ++KT K
Sbjct: 1086 -TLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLK 1135
Score = 55.1 bits (131), Expect = 2e-06
Identities = 107/564 (18%), Positives = 239/564 (42%), Gaps = 48/564 (8%)
Query: 3201 DLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEES 3260
D+ +++++ + +LL A+ REEQ E + S+++ + L+ E+
Sbjct: 707 DITQLEKEVNVCKQYYQELLKSAE-REEQEESVYNL---YISEVRNIRLRLENCEDRLIR 762
Query: 3261 QGPVGMETETINQQLNMFKVFQKE----EIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGL 3316
Q +E + +++ ++F++ ++E E+E L+ + + AA S+S L
Sbjct: 763 QIRTPLERDDLHE--SVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTL 820
Query: 3317 EHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQ--DALESLLSWMVDTEELVANQKP 3374
+L+ V + + +L+ L Q +AL L + EE V K
Sbjct: 821 RSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKN 880
Query: 3375 PS----AEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLS 3430
+ K ++++ E++ + L+D + I E K + D ++
Sbjct: 881 NIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERD-LDFDWHKEKAD 939
Query: 3431 LLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASK 3490
L RW+ + + + R R LEGI + + +T PL++W+ +E + + SK
Sbjct: 940 QLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSK 999
Query: 3491 -LEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQ 3549
L Q+ Q K L +I + + + S KD + + + ++ Q
Sbjct: 1000 TLATQLNQQKMLVSEIEMKQSKMDECQKYAEQY----SATVKDYELQTMTYRAM--VDSQ 1053
Query: 3550 EKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRV 3609
+KS + +Q +A + ++ ++L + +++ ++ + L + + E +
Sbjct: 1054 QKSPVKRRRMQS---SADLIIQEFMDLRTRYTALVTLMTQYI--KFAGDSLKRLEEEEKS 1108
Query: 3610 LQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKT-- 3667
L+E+ +K++V++A + L++ + ++D +A K + K+S++ T
Sbjct: 1109 LEEE---KKEHVEKA-----KELQKWVSNISKTLKDAEKAGKPPFSK-QKISSEEISTKK 1159
Query: 3668 --LEQALQLARRLHSTHEELCTWLDKVEVE----LLSYETQVLKGEEASQAQ--MRPKEL 3719
L +ALQ + + H + T ++ E+E L +L E Q Q ++
Sbjct: 1160 EQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDV 1219
Query: 3720 KKEAKNNKALLDSLNEVSSALLEL 3743
K E K +K + ++++ + +L +
Sbjct: 1220 KVEEKLDKVIAGTIDQTTGEVLSV 1243
Score = 47.8 bits (112), Expect = 3e-04
Identities = 186/1109 (16%), Positives = 432/1109 (38%), Gaps = 198/1109 (17%)
Query: 1218 LKNTQAAEALVK--LYETKLCEEEAVIADKNNIENLISTLK------QWRSEV------- 1262
LK Q + L+K L + L EEE + ++ N + ++ +W S++
Sbjct: 253 LKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHL 312
Query: 1263 DEKRQVFHALED---ELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQID 1319
+ + V A+E+ L++AK +M K + EK +L ++ +
Sbjct: 313 ENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLT------YAEKLHRLESQYAKLLNTSR 366
Query: 1320 NRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVS 1379
N+ R L+ + + R T + W+ + E + ++ + E + +A + + L+
Sbjct: 367 NQERHLDTLHNFVS--RATNELI--WLNEKE--EEEVAYDWSERNTNIARKKDYHAELMR 420
Query: 1380 EIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQE 1439
E++ K+ + Q+ AEQ L YRA + +Q ++ + +++
Sbjct: 421 ELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQC-------VEQ 473
Query: 1440 FMDLRTRYTALVT---LMTQYIKFAGDSLKRLEEEEKS-----LEEEKKEHVEKAKELQK 1491
+ T Y T Y++ D+++R ++S LE+ +E +E+ +EL +
Sbjct: 474 HIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQ 533
Query: 1492 WVSNISKTLKDAEKAG--KPPFSKQKISSE------------EISTKKEQL--------- 1528
+ S I+ + A+ KP S + + EI+ K+
Sbjct: 534 YKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHR 593
Query: 1529 ----------SEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYN---------LLF 1569
+EA+ F +K + N +E+Q + + ++ + +
Sbjct: 594 AKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSW 653
Query: 1570 SESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDG 1629
+ ++ + S ++ + E QQ + +L ++ E+ L QE+ +
Sbjct: 654 HYLINEIDRIRASNVASIKTMLPGEHQQV-------LSNLQSRFEDFLEDSQESQVFSGS 706
Query: 1630 TVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKI 1689
+ +L+K++ Q E++K+ E ++++++ ++E +
Sbjct: 707 DIT---------QLEKEVNVCKQYYQELLKSAER---------EEQEESVYNLYISEVR- 747
Query: 1690 KCEQLNLKAEQSKKELDKVVTTAIKEET--EKVAAVKQLEESKTKIENLLDWLSNVDKDS 1747
+ L+ E + L + + T ++ + E V + + E+ K ++E L D L +
Sbjct: 748 ---NIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKC 804
Query: 1748 ERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKV 1807
E F + S++ + ++ +N+NQ Y
Sbjct: 805 EE--------------FFSQAAASSSV------------PTLRSELNVVLQNMNQVYSMS 838
Query: 1808 KAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKN-MKELKVHYETALAESE 1866
+K+ + + V+ TQ+A+ L++ L EE KN ++ L + +E +
Sbjct: 839 STYIDKLKTVN-LVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVD 897
Query: 1867 KKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSED 1926
+K ++ H+L++EL+K A E ++ + + + + AD + ++R ++
Sbjct: 898 EKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQL------VERWQNVHVQ 951
Query: 1927 VISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKC 1986
+ + DL I G + + D T R++Q ++ + ++L ++
Sbjct: 952 IDNRLRDLEGI---GKSLKYYRDTYHPLDDWIQQVETTQRKIQ---ENQPENSKTLATQL 1005
Query: 1987 NVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKAL 2046
N K LV + + + + + C+ A E + K+ + Q +A+
Sbjct: 1006 ----NQQKMLVSEIEMKQ-------SKMDECQKYA-----EQYSATVKDYELQTMTYRAM 1049
Query: 2047 QGQISSQQVAVEKLKKTAEVL----LDAR---GSLLPAKNDIQKTLDDIVGRYEDLSKSV 2099
V +++ +A+++ +D R +L+ K D + R E+ KS+
Sbjct: 1050 VDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSL 1109
Query: 2100 NERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQ 2159
E ++ + E+ W+ N+ +LK+ + + Q I S+ I ++
Sbjct: 1110 EEEKKE----------HVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKK 1159
Query: 2160 DIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELK 2219
+ ++ + + K + + L+ ++K L ++ E+L +++E +
Sbjct: 1160 E--QLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLL---FSESLKQLQESQ 1214
Query: 2220 TK--VELFENLSEKLQTFLETKTQALTEV 2246
T V++ E L + + ++ T + V
Sbjct: 1215 TSGDVKVEEKLDKVIAGTIDQTTGEVLSV 1243
Score = 46.2 bits (108), Expect = 9e-04
Identities = 178/1077 (16%), Positives = 401/1077 (37%), Gaps = 210/1077 (19%)
Query: 3683 EELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLE 3742
++L W+D+++V+L E G + + + K + + SL E + ++
Sbjct: 283 QDLLNWVDEMQVQLDRTEW----GSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQ 338
Query: 3743 LVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETE 3802
+ EK+ +++ +L++ + Q+ +D F A EL W+ E E
Sbjct: 339 MTAPLKLTYAEKLHRLESQYAKLLNTSRNQE-RHLDTL----HNFVSRATNELIWLNEKE 393
Query: 3803 KKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMK 3862
++ ++ + + + + +K + E++R
Sbjct: 394 EE-----EVAYDWSERNTNIARKKDYHAELMR---------------------------- 420
Query: 3863 KKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQ-LPAPA 3921
+LD+ +N ++ +I + L+ A+ + + + W W+ + + Q +
Sbjct: 421 -ELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENT 479
Query: 3922 LEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYS 3981
+E +E LR L +IQ KY +
Sbjct: 480 AYFEFFNDAKEATDYLRNLKD-------------------------AIQRKYSCDRSSSI 514
Query: 3982 QIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVE----------RLRQPPSISAE 4031
ED+ + ++ E + Q+ I ++ + I++ + P +
Sbjct: 515 HKLEDLVQESMEEKEEL---LQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICD 571
Query: 4032 VEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVF 4091
+I+ I ++ + + ++ + G E + S K D +++
Sbjct: 572 YRQIEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQ 631
Query: 4092 IWENIHTLVEEREAKLLDVME---LAEKFWCDHMSLIVTIK-----DTQDFIRDLEDPGI 4143
++N+ TL E + V+ L + S + +IK + Q + +L+
Sbjct: 632 QYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFE 691
Query: 4144 DPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACG--EPDKPIVKKSIDELNSA 4201
D ++ QE+ +I L++E+++ EL+ + E ++ + I E+ +
Sbjct: 692 D--FLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRN- 748
Query: 4202 WDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQI 4261
+ ++ D+L ++ ++ D ++VF T+ E +K+++
Sbjct: 749 ---IRLRLENCEDRLIRQIRTPLERDDLHESVFRI---------------TEQEKLKKEL 790
Query: 4262 EELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIIN 4321
E LK ++ + ++ E + S T++ L + + +
Sbjct: 791 ERLKD----------DLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSST 840
Query: 4322 RQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDV 4381
KL+ L L Q A E L L T+ L E++ V D IE ++ +++V
Sbjct: 841 YIDKLKTVNLVLKNTQAA--EALVKLYETK--LCEEEAVIADKNNIENLISTLKQWRSEV 896
Query: 4382 LAHQSTVEAVN------KAGNDLIESSAGEEASNL---QNKLEVLNQRWQNVLEKTEQRK 4432
+ A+ KA +D + + E + + K + L +RWQNV + + R
Sbjct: 897 DEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRL 956
Query: 4433 QQLDGALRQAKGFHGEIEDLQQWLTD---TERHLLASKPLGGLPETAKEQLNVHMEVCAA 4489
+ L+G + K + L W+ T+R + ++P +T QLN + +
Sbjct: 957 RDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENS--KTLATQLNQQKMLVSE 1014
Query: 4490 FEAKEE------------------------TYKSLMQKGQQ--MLARCPKSAETNIDQDI 4523
E K+ TY++++ Q+ + R +S+ I Q+
Sbjct: 1015 IEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEF 1074
Query: 4524 NNLKEKWESVET--------------KLNERKTKLEEALNLAMEFHNSLQDFINWLTQAE 4569
+L+ ++ ++ T +L E + LEE +E LQ +++ +++
Sbjct: 1075 MDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTL 1134
Query: 4570 QTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIK 4629
+ A +P + K+ + E+++ +EQ+ E +T ++ F K
Sbjct: 1135 KDAEKAGKP---------PFSKQKISSEEISTKKEQLSEALQT---IQLFLAKHG----D 1178
Query: 4630 NLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELE 4686
+ ++ EK V+ L E ++ +S+ ++ L+ES+ S D ++E
Sbjct: 1179 KMTDEERNELEKQVKTLQE-------------SYNLLFSESLKQLQESQTSGDVKVE 1222
Score = 45.4 bits (106), Expect = 0.002
Identities = 180/1047 (17%), Positives = 396/1047 (37%), Gaps = 200/1047 (19%)
Query: 1891 HWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKS 1950
+W+ + + +L+ E G+D + + + L+ K+ + + L+ IS ++ K
Sbjct: 287 NWVDEMQVQLDRTEWGSD-LPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLK- 344
Query: 1951 CSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGL 2010
T+ E +L+ S Y+K N + +D ++ +
Sbjct: 345 ------------LTYAEKLHRLE-------SQYAKLLNTSRNQERHLDTLHNFVSRATNE 385
Query: 2011 LAGLQACEATASKHLSEPIAVD----PKNLQRQLEETKALQGQISSQQVAVEKLKKTAEV 2066
L L E E +A D N+ R+ + L ++ ++ ++ +++ AE
Sbjct: 386 LIWLNEKE-------EEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQ 438
Query: 2067 LL----DARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDE 2122
LL AR ++ + +Q I+ + + + + E T + E
Sbjct: 439 LLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKEN--------TAYFEFFNDAKE 490
Query: 2123 MLDWMGNVESSLKEQGQVPLNSTA--LQDIISKNIMLEQDIAGRQSSINAMNEKVKKFME 2180
D++ N++ +++ + +S+ L+D++ +++ ++++ +S+I + K K ++
Sbjct: 491 ATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQ 550
Query: 2181 ----TTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFL 2236
+D +S+ K + +K E + + K ++ +
Sbjct: 551 LKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISPTGNEAMV-- 608
Query: 2237 ETKTQALTEVDVPGKDVTELSQYMQESTSEFLE--HKKHLEVL-----HSLLKEIS---S 2286
V P K+ +L+ +++ L H+ H+ + H L+ EI +
Sbjct: 609 ---PSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRA 665
Query: 2287 HGLPSDKALVL-EKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKET 2345
+ S K ++ E LS ED +++ +E+ + + V K + +E
Sbjct: 666 SNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQEL 725
Query: 2346 TKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCN----LISAVTT 2401
L+ ++ +++ S+ I +V N + L N LI + T
Sbjct: 726 -------------------LKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRT 766
Query: 2402 PAKAIAAVKSGGAVLNGE-------------GTATNT-EEFWANKGLTS----------- 2436
P + +S + E GT TN EEF++ +S
Sbjct: 767 PLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNV 826
Query: 2437 IKKDMTDI---SHGYED----LGLLLKD-KIAELNTKLSKLQKAQEESS-AMMQWLQKMN 2487
+ ++M + S Y D + L+LK+ + AE KL + + +EE+ A ++ +
Sbjct: 827 VLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLI 886
Query: 2488 KTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAP 2547
T +W +++V++ + L+ + K + + D++ + +E +
Sbjct: 887 STLKQW------------RSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFD-- 932
Query: 2548 RW-KQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKE-LMVSVL 2605
W K+ ++ +WQ ++ +R + LE +L ++ L W+ + E +
Sbjct: 933 -WHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQ 991
Query: 2606 GPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLA 2665
+ L TQ Q ++L+ E ++ + ++ EQ +
Sbjct: 992 ENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQK------------------YAEQYS 1033
Query: 2666 AVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDA 2725
A + ++ T D ++ VK + QS + + DL + ++ + +
Sbjct: 1034 ATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTL------ 1087
Query: 2726 MNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKA-ELSRQLEGILKSFKDV 2784
M Q ++ A + +++E+K ++ + KE KA EL + + I K+ KD
Sbjct: 1088 MTQYIKFAGDSLKRLEEEEKSLEEEK----------KEHVEKAKELQKWVSNISKTLKDA 1137
Query: 2785 EQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHK 2844
E+ A F + + + TKKE+ +S L ++ + H
Sbjct: 1138 EK-------------AGKPPFSKQKISSEE-ISTKKEQ------LSEALQTIQLFLAKHG 1177
Query: 2845 DFSKTLTAQSHMYE---KTIAEGENLL 2868
D K + + E KT+ E NLL
Sbjct: 1178 D--KMTDEERNELEKQVKTLQESYNLL 1202
Score = 42.4 bits (98), Expect = 0.013
Identities = 100/563 (17%), Positives = 217/563 (38%), Gaps = 89/563 (15%)
Query: 2695 YQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQ---QLETAQKMKQEIQQEKKQIKVAQ 2751
Y S +R++ +L + +++L + D +++ ++ +K+K+E+++ K +
Sbjct: 742 YISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTIT 801
Query: 2752 ALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRD 2811
CE+ + L +L +L++ V + ++ L++ + + ++
Sbjct: 802 NKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTV----NLVLKNTQA 857
Query: 2812 FQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKT 2871
+A + + + + + A + +E+LI K + + + ++
Sbjct: 858 AEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFH------------- 904
Query: 2872 QGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNN 2931
AL+ +L K D K KER+ EKA + E+ + + ID +
Sbjct: 905 ------ALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRD 958
Query: 2932 LEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENK 2991
LE I KSL+ D + + + + + + E E +K
Sbjct: 959 LEGIG---------------KSLKYYRDTYHPLDDWIQQVETTQRKIQENQPE----NSK 999
Query: 2992 SLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYS 3051
+L QL+ +K + + K + E K +++ K+ + +
Sbjct: 1000 TL-------ATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDY---------ELQT 1043
Query: 3052 NKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQ 3111
Y M+ +QQKS + A + Q+ + ++ T+ V L + I +L +
Sbjct: 1044 MTYRAMVDSQQKSPVKRRRMQSSADLIIQEFM--DLRTRYTALVTLMTQYIKFAGDSLKR 1101
Query: 3112 QVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAE-----TLQKQKE 3166
+E+ S E K +E + E + +++ +DAE KQK
Sbjct: 1102 LEEEEKSLEEEK-----------KEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKI 1150
Query: 3167 TIKAFLKKLEALMASNDNANKTCKMMLA---TEETSPDLVGIKRDLEALSKQCNKLLDRA 3223
+ + K E L A +T ++ LA + T + +++ ++ L + N L +
Sbjct: 1151 SSEEISTKKEQL----SEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSES 1206
Query: 3224 --QAREEQVEGTIKRLEEFYSKL 3244
Q +E Q G +K +EE K+
Sbjct: 1207 LKQLQESQTSGDVK-VEEKLDKV 1228
Score = 40.0 bits (92), Expect = 0.064
Identities = 147/728 (20%), Positives = 270/728 (37%), Gaps = 111/728 (15%)
Query: 4402 SAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTER 4461
S+G E ++LQ L+++ R K + LD L + + ++DL W+ + +
Sbjct: 242 SSGVEPNSLQT-LKLMQIR------KPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQV 294
Query: 4462 HLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQ 4521
L ++ LP + + L H V A E E + K QM A + +
Sbjct: 295 QLDRTEWGSDLP-SVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKL-- 351
Query: 4522 DINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLI 4581
+ ES KL E L+ F + + + WL + E+
Sbjct: 352 ------HRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE----------- 394
Query: 4582 LDTVLFQIDEHKV-FANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKN---------L 4631
+ V + E A + + H E + ELD+ ++K + + +L++N
Sbjct: 395 -EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAY 453
Query: 4632 LISVQSRWEKVVQ--RLVERG---------------------RSLDDA--RK----RAKQ 4662
++Q++W ++Q + VE+ R+L DA RK R+
Sbjct: 454 RAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSS 513
Query: 4663 FHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTG 4722
H+ + E +EE E+ L + IAN K KT + Q K K S+
Sbjct: 514 IHKLEDLVQESMEEKEELLQYKSTIANLMGKAKT-IIQLKPRNSDCPLKTSIPIKAICDY 572
Query: 4723 RSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFT--DALQAL 4780
R + E T DD L + + R KW I EA++ S FT +
Sbjct: 573 RQI-EITIYKDDECVLAN--NSHRAKWKVISPTG-------NEAMVPSVCFTVPPPNKEA 622
Query: 4781 IDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGK-RTSSVQALK---------- 4829
+D R+E Q + + + M + + E+ + R S+V ++K
Sbjct: 623 VDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQV 682
Query: 4830 -RSARELIEGSRDDSSWVKV-QMQELSTRWETVCALSISKQTRLEAALRQAEE------F 4881
+ + E +DS +V +++ + V Q L++A R+ +E +
Sbjct: 683 LSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLY 742
Query: 4882 HSVVHALLEWLAEAEQTLRFHGVLPDDEDALRT---LIDQHKEFMKKLEEKRAELNKATT 4938
S V + L E L P + D L I + ++ K+LE + +L T
Sbjct: 743 ISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITN 802
Query: 4939 MGDTVLA-ICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLAS---ALAGLIAKQELL 4994
+ + S+ T++ + ++ +V + + + +L + L A + L+
Sbjct: 803 KCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALV 862
Query: 4995 EALLAWLQWAETTLTDKDK-----EVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTK 5049
+ L E + DK+ + Q EV +E+ + + D++ K
Sbjct: 863 KLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFK 922
Query: 5050 TYKRRAAD 5057
TYK R D
Sbjct: 923 TYKERDLD 930
>gi|4502443 dystonin isoform 1e precursor [Homo sapiens]
Length = 2649
Score = 2122 bits (5499), Expect = 0.0
Identities = 1215/1987 (61%), Positives = 1414/1987 (71%), Gaps = 138/1987 (6%)
Query: 422 RLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLL 481
RLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLL
Sbjct: 56 RLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLL 115
Query: 482 RQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISG 541
RQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISG
Sbjct: 116 RQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISG 175
Query: 542 ITQSLNSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPS 601
ITQSLNSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPS
Sbjct: 176 ITQSLNSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPS 235
Query: 602 GLVPNFSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQ 661
GLVPNFSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQ
Sbjct: 236 GLVPNFSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQ 295
Query: 662 LDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLE 721
LDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLE
Sbjct: 296 LDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLE 355
Query: 722 SQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYH 781
SQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYH
Sbjct: 356 SQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYH 415
Query: 782 AELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHI 841
AELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHI
Sbjct: 416 AELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHI 475
Query: 842 KENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYK 901
KENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYK
Sbjct: 476 KENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYK 535
Query: 902 STIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAK 961
STIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAK
Sbjct: 536 STIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAK 595
Query: 962 WKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHY 1021
WKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHY
Sbjct: 596 WKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHY 655
Query: 1022 LINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEV 1081
LINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEV
Sbjct: 656 LINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEV 715
Query: 1082 NVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHE 1141
NVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHE
Sbjct: 716 NVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHE 775
Query: 1142 SVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVY 1201
SVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVY
Sbjct: 776 SVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVY 835
Query: 1202 SMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSE 1261
SMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSE
Sbjct: 836 SMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSE 895
Query: 1262 VDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNR 1321
VDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNR
Sbjct: 896 VDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNR 955
Query: 1322 LRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEI 1381
LRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEI
Sbjct: 956 LRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEI 1015
Query: 1382 EMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFM 1441
EMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFM
Sbjct: 1016 EMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFM 1075
Query: 1442 DLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLK 1501
DLRTRYTALVTLMTQYIKFAGDSLKRLEEEE +E EH + LQ+ + + L+
Sbjct: 1076 DLRTRYTALVTLMTQYIKFAGDSLKRLEEEEIKRCKETSEHGAYSDLLQRQKATV---LE 1132
Query: 1502 DAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTL 1561
+++ GK S+ + E+ +K ++ E L K+ + NEL KQ + +
Sbjct: 1133 NSKLTGK--ISELERMVAELKKQKSRVEEEL-----------PKVREAAENELRKQQRNV 1179
Query: 1562 QESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQ 1621
++ SL++++ + + E + + ++ + +L+ + L + E + +
Sbjct: 1180 EDI-------SLQKIRAESEAKQYRRELETIVREKEAAERELERVRQLTIEAEAKRAAVE 1232
Query: 1622 EAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIE 1681
E + + +L++ + L+ ++ +L ++ + ++E K E++ L
Sbjct: 1233 ENLL--NFRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRDNEEELLKL 1290
Query: 1682 QKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLS 1741
K E + L + + ++K+L + K++ E A K E T EN L
Sbjct: 1291 IKQME-----KDLAFQKQVAEKQLKE------KQKIELEARRKITEIQYTCRENALPVCP 1339
Query: 1742 NVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTT----Q 1797
S RA T +Q E D+ L+ VD Q
Sbjct: 1340 ITQATSCRAVTGLQQ-------------------EHDKQKAEELKQQVDELTAANRKAEQ 1380
Query: 1798 ENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVH 1857
+ Y+ Q EK S+ +A ++ + + + L E K++ +K
Sbjct: 1381 DMRELTYELNALQLEKTSSEEKARLLKDKLDETNNTLRCLKLELERKDQAEKG------- 1433
Query: 1858 YETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKL 1917
Y L E +++ T EE + +D + + + + ELE+L + + ++
Sbjct: 1434 YSQQLRELGRQLNQTTGKAEEAMQEASDLKKIK---RNYQLELESLNHEKGKLQREVDRI 1490
Query: 1918 KRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCS-KRDGGKVDTSATHREV------QR 1970
R + +E I H + + + LE + C K D K +H ++ ++
Sbjct: 1491 TRAHAVAEKNIQHLNS-QIHSFRDEKELERLQICQRKSDHLKEQFEKSHEQLLQNIKAEK 1549
Query: 1971 KLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIA 2030
+ + R K N LK V++ + + ++ +QA SE I
Sbjct: 1550 ENNDKIQRLNEELEKSNECAEMLKQKVEELTRQNNETKLMMQRIQA--------ESENIV 1601
Query: 2031 VDPKNLQRQLEETK----ALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLD 2086
++ + +Q++ E K + Q+ S + K KT + D Q+ +
Sbjct: 1602 LEKQTIQQRCEALKIQADGFKDQLRSTNEHLHKQTKT--------------EQDFQRKIK 1647
Query: 2087 DIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTA 2146
+ EDL+KS N +E Q +++ +Q+ E+ + + +S +E+ +
Sbjct: 1648 CL---EEDLAKSQNLVSEFKQKCDQQNIIIQNTKKEVRNLNAELNASKEEKRRG------ 1698
Query: 2147 LQDIISKNIMLEQDIAGRQSSINAMNEKVKK-----FMETTDPSTASSLQAKMKDLSARF 2201
EQ + +Q+ + +N ++KK ++T + ++ S +F
Sbjct: 1699 -----------EQKVQLQQAQVQELNNRLKKVQDELHLKTIEEQMTHRKMVLFQEESGKF 1747
Query: 2202 SEASHKHKETLAKMEELKTKVEL-FENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYM 2260
+++ + ++ + K+ E K E + + + ++A + ++ EL + +
Sbjct: 1748 KQSAEEFRKKMEKLMESKVITENDISGIRLDFVSLQQENSRAQENAKLCETNIKELERQL 1807
Query: 2261 QESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIK----- 2315
Q+ E ++ +H+E H + L + K V + ++ KE E +
Sbjct: 1808 QQ-YREQMQQGQHMEANHYQKCQKLEDELIAQKREVENLKQKMDQQIKEHEHQLVLLQCE 1866
Query: 2316 -EKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEK 2374
+KK C + D F++ VK + + +++ + P+ L + ++ + L+EK
Sbjct: 1867 IQKKSTAKDCTFKPD-FEMTVKECQHSGELSSRNTGHLHPT-PRSPLLRWTQEPQPLEEK 1924
Query: 2375 WSLKTPE 2381
W + E
Sbjct: 1925 WQHRVVE 1931
Score = 98.6 bits (244), Expect = 2e-19
Identities = 301/1713 (17%), Positives = 678/1713 (39%), Gaps = 246/1713 (14%)
Query: 1891 HWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKS 1950
+W+ + + +L+ E G+D + + + L+ K+ + + L+ IS ++ K
Sbjct: 287 NWVDEMQVQLDRTEWGSD-LPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLK- 344
Query: 1951 CSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGL 2010
T+ E +L+ S Y+K N + +D ++ +
Sbjct: 345 ------------LTYAEKLHRLE-------SQYAKLLNTSRNQERHLDTLHNFVSRATNE 385
Query: 2011 LAGLQACEATASKHLSEPIAVD----PKNLQRQLEETKALQGQISSQQVAVEKLKKTAEV 2066
L L E E +A D N+ R+ + L ++ ++ ++ +++ AE
Sbjct: 386 LIWLNEKE-------EEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQ 438
Query: 2067 LL----DARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDE 2122
LL AR ++ + +Q I+ + + + + E T + E
Sbjct: 439 LLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKEN--------TAYFEFFNDAKE 490
Query: 2123 MLDWMGNVESSLKEQGQVPLNSTA--LQDIISKNIMLEQDIAGRQSSINAMNEKVKKFME 2180
D++ N++ +++ + +S+ L+D++ +++ ++++ +S+I + K K ++
Sbjct: 491 ATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQ 550
Query: 2181 ----TTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFL 2236
+D +S+ K + +K E + + K ++ +
Sbjct: 551 LKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISPTGNEAMV-- 608
Query: 2237 ETKTQALTEVDVPGKDVTELSQYMQESTSEFLE--HKKHLEVL-----HSLLKEIS---S 2286
V P K+ +L+ +++ L H+ H+ + H L+ EI +
Sbjct: 609 ---PSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRA 665
Query: 2287 HGLPSDKALVL-EKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKET 2345
+ S K ++ E LS ED +++ +E+ + + V K + +E
Sbjct: 666 SNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQEL 725
Query: 2346 TKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCN----LISAVTT 2401
L+ ++ +++ S+ I +V N + L N LI + T
Sbjct: 726 -------------------LKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRT 766
Query: 2402 PAKAIAAVKSGGAVLNGE-------------GTATNT-EEFWANKGLTS----------- 2436
P + +S + E GT TN EEF++ +S
Sbjct: 767 PLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNV 826
Query: 2437 IKKDMTDI---SHGYED----LGLLLKD-KIAELNTKLSKLQKAQEESS-AMMQWLQKMN 2487
+ ++M + S Y D + L+LK+ + AE KL + + +EE+ A ++ +
Sbjct: 827 VLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLI 886
Query: 2488 KTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAP 2547
T +W +++V++ + L+ + K + + D++ + +E +
Sbjct: 887 STLKQW------------RSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFD-- 932
Query: 2548 RW-KQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKE-LMVSVL 2605
W K+ ++ +WQ ++ +R + LE +L ++ L W+ + E +
Sbjct: 933 -WHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQ 991
Query: 2606 GPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLA 2665
+ L TQ Q ++L+ E ++ + ++ + S +D L+ + +
Sbjct: 992 ENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQ-YSATVKDYELQTMTYRAMV 1050
Query: 2666 AVTQKWDSLTGQLSDRCDWIDQAIVK-STQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPD 2724
QK ++ D I Q + T+Y +L+ ++ + K + +
Sbjct: 1051 DSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYI-----KFAGDSLKRLEEE 1105
Query: 2725 AMNQQLETAQ--KMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFK 2782
+ + ET++ +Q++K + L +S L E + AEL +Q + +
Sbjct: 1106 EIKRCKETSEHGAYSDLLQRQKATVLENSKLTGKISEL---ERMVAELKKQKSRVEEELP 1162
Query: 2783 DVEQKAENHVQHLQ--------SACASSHQFQQMSRDFQAWLDTK---KEEQNKSHPISA 2831
V + AEN ++ Q + + +Q R+ + + K + E + ++
Sbjct: 1163 KVREAAENELRKQQRNVEDISLQKIRAESEAKQYRRELETIVREKEAAERELERVRQLTI 1222
Query: 2832 KLDVLESLIKDHKDFSKTLTAQSHMYEKTIAE---GENLLLKTQGSEKAALQLQLNTIKT 2888
+ + + ++++ + ++ +T+ + ++L L +K L +L +
Sbjct: 1223 EAEAKRAAVEENLLNFRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRD 1282
Query: 2889 NWDTFNKQVKERENKL---KESLEKALKYKEQVE-TLWPWIDKCQNNLEEIKFCLDPAEG 2944
N + K +K+ E L K+ EK LK K+++E I + Q E + P
Sbjct: 1283 NEEELLKLIKQMEKDLAFQKQVAEKQLKEKQKIELEARRKITEIQYTCRENALPVCPITQ 1342
Query: 2945 ENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQL 3004
S + LQ+E D+ E L + L T N+ Q + +T +L
Sbjct: 1343 ATSCRAVTGLQQEHDKQ--KAEELKQQVDEL-----------TAANRKAEQDMRELTYEL 1389
Query: 3005 HSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKS 3064
++ + + +K + ++ E+ L+C K +L+ D + YS +
Sbjct: 1390 NALQLEKTSSEEKARLLKDKLDETNNTLRCLKLELERKDQ-AEKGYS-----------QQ 1437
Query: 3065 LQALKHQVDLAKRLAQDLVVEASDSKGTS-DVLLQVETIAQEHSTLSQQVDEKCSFLETK 3123
L+ L Q++ A++ + EASD K + L++E++ E L ++VD T+
Sbjct: 1438 LRELGRQLNQTTGKAEEAMQEASDLKKIKRNYQLELESLNHEKGKLQREVDR-----ITR 1492
Query: 3124 LQGIGHFQNTIREMFSQFAEFDD--ELDSMAPVGRDAETLQKQKETIKAFLKKLEALMAS 3181
+ + I+ + SQ F D EL+ + R ++ L++Q E K+ + L+ + A
Sbjct: 1493 AHAVA--EKNIQHLNSQIHSFRDEKELERLQICQRKSDHLKEQFE--KSHEQLLQNIKAE 1548
Query: 3182 NDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNK---LLDRAQAREEQV---EGTI- 3234
+N +K ++ E+++ +K+ +E L++Q N+ ++ R QA E + + TI
Sbjct: 1549 KENNDKIQRLNEELEKSNECAEMLKQKVEELTRQNNETKLMMQRIQAESENIVLEKQTIQ 1608
Query: 3235 KRLEEFYSKLKEFSILLQKAEEH--------EESQGPVGMETETINQQLNMFKVFQKEEI 3286
+R E + F L+ EH ++ Q + E + + N+ F++
Sbjct: 1609 QRCEALKIQADGFKDQLRSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEFKQ--- 1665
Query: 3287 EPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALL 3346
+ QQ++ +IQ+ K + L +L+ + +KV + AQ+QE
Sbjct: 1666 ---KCDQQNI------IIQNTKK--EVRNLNAELNASKEEKRRGEQKVQLQQAQVQELNN 1714
Query: 3347 HCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVI 3406
+ QD L T + + S +FK ++ + +K +++L++ + T I
Sbjct: 1715 RLKKVQDELHLKTIEEQMTHRKMVLFQEESGKFK--QSAEEFRKKMEKLMESKVITENDI 1772
Query: 3407 KREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEP 3466
G ++ + + + + L ++ + L + + Q++ + ++ +
Sbjct: 1773 --SGIRLDFVSLQQENSRAQENAKLCETNIKELERQLQQYREQMQQGQHMEANHYQKCQK 1830
Query: 3467 LNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHK 3499
L + L ++ + N + K+++QI +H+
Sbjct: 1831 LEDELIAQKREVENLK------QKMDQQIKEHE 1857
Score = 80.9 bits (198), Expect = 3e-14
Identities = 262/1418 (18%), Positives = 538/1418 (37%), Gaps = 200/1418 (14%)
Query: 3201 DLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEES 3260
D+ +++++ + +LL A+ REEQ E + S+++ + L+ E+
Sbjct: 707 DITQLEKEVNVCKQYYQELLKSAE-REEQEESVYNL---YISEVRNIRLRLENCEDRLIR 762
Query: 3261 QGPVGMETETINQQLNMFKVFQKE----EIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGL 3316
Q +E + +++ ++F++ ++E E+E L+ + + AA S+S L
Sbjct: 763 QIRTPLERDDLHE--SVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTL 820
Query: 3317 EHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQ--DALESLLSWMVDTEELVANQKP 3374
+L+ V + + +L+ L Q +AL L + EE V K
Sbjct: 821 RSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKN 880
Query: 3375 PS----AEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLS 3430
+ K ++++ E++ + L+D + I E K + D ++
Sbjct: 881 NIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERD-LDFDWHKEKAD 939
Query: 3431 LLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASK 3490
L RW+ + + + R R LEGI + + +T PL++W+ +E + + SK
Sbjct: 940 QLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSK 999
Query: 3491 -LEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQ 3549
L Q+ Q K L +I + + + S KD + + + ++ Q
Sbjct: 1000 TLATQLNQQKMLVSEIEMKQSKMDECQKYAEQY----SATVKDYELQTMTYRAM--VDSQ 1053
Query: 3550 EKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRV 3609
+KS + +Q +A + ++ ++ L + L L Q G L+
Sbjct: 1054 QKSPVKRRRMQS---SADLIIQEFMD----LRTRYTALVTLMTQYIKFAG-----DSLKR 1101
Query: 3610 LQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLE 3669
L+E+ + R K+T+ E D L+ KA + +KL+ +++
Sbjct: 1102 LEEEEIKR--------------CKETS--EHGAYSDLLQRQKATVLENSKLTGKISELER 1145
Query: 3670 QALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKAL 3729
+L ++ EEL + E EL + V E+ S ++R + K+ +
Sbjct: 1146 MVAELKKQKSRVEEELPKVREAAENELRKQQRNV---EDISLQKIRAESEAKQYRRELET 1202
Query: 3730 LDSLNEVSSALLELVPWRAREGLEKMVAED----NERYRLVSDTITQKVEEIDAAILRSQ 3785
+ E + LE V E K A + N R +L +T T++ E
Sbjct: 1203 IVREKEAAERELERVRQLTIEAEAKRAAVEENLLNFRNQLEENTFTRRTLE--------- 1253
Query: 3786 QFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKS 3845
++K +SL D L+ QK ME LR K
Sbjct: 1254 -------------DHLKRKDLSLND-----------LEQQKNKLMEELRRK--------- 1280
Query: 3846 GHKIMTACSEEEKQSMKKKLDKVLKNYDTIC--QINSERYLQLERAQSLVNQFWETYEEL 3903
+EEE + K+++K L + Q+ ++ ++LE + + + E
Sbjct: 1281 ------RDNEEELLKLIKQMEKDLAFQKQVAEKQLKEKQKIELEARRKITEIQYTCRENA 1334
Query: 3904 WPWLTETQSIISQLPAPALEYETLRQQQEE-HRQLRELIAEHKPHIDKMNKTGPQLLELS 3962
P TQ+ S L+ E +Q+ EE +Q+ EL A ++ M + +L L
Sbjct: 1335 LPVCPITQA-TSCRAVTGLQQEHDKQKAEELKQQVDELTAANRKAEQDMRELTYELNALQ 1393
Query: 3963 PGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERL 4022
+ S ++ + D L + ++ + L+ + ++ ++ L + +
Sbjct: 1394 LEKTSSEEKARLLKDKL-DETNNTLRCLKLELERKDQAEKGYSQQLRELGRQLNQTTGKA 1452
Query: 4023 RQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAV 4082
+ +++++KIK +N +++E L +E K + E D+ A AV
Sbjct: 1453 EEAMQEASDLKKIK------RNYQLELESLN--HEKGKLQRE--------VDRITRAHAV 1496
Query: 4083 QDKLDQMVFIWENIHTLVEEREAKLLDVME-----LAEKFWCDHMSLIVTI---KDTQDF 4134
+K + + IH+ +E+E + L + + L E+F H L+ I K+ D
Sbjct: 1497 AEK--NIQHLNSQIHSFRDEKELERLQICQRKSDHLKEQFEKSHEQLLQNIKAEKENNDK 1554
Query: 4135 IRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKS 4194
I+ L + +++ E AE ++++++ L + + L + I A E + + K++
Sbjct: 1555 IQRLNEE------LEKSNECAEMLKQKVEELTRQ-NNETKLMMQRIQAESE-NIVLEKQT 1606
Query: 4195 IDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDL 4254
I + A +KD++ E + + + Q + + DL
Sbjct: 1607 IQQRCEALKIQADGFKDQLRSTNEHLHKQTKTEQDFQ-------------RKIKCLEEDL 1653
Query: 4255 ETVKQQIEELKQ--FKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIW 4312
+ + E KQ + Q + E N AEL K + + VQ +
Sbjct: 1654 AKSQNLVSEFKQKCDQQNIIIQNTKKEVRNLNAELNASKEEKRRGEQKVQ--------LQ 1705
Query: 4313 DSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELA 4372
+ + + NR K++ L L + +TH + +L +++ A E
Sbjct: 1706 QAQVQELNNRLKKVQDEL--------HLKTIEEQMTHRKMVLFQEESGKFKQSAEEFRKK 1757
Query: 4373 KHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRK 4432
++++ V+ +G L S +E S Q ++ + + + +Q +
Sbjct: 1758 MEKLMESKVITENDI------SGIRLDFVSLQQENSRAQENAKLCETNIKELERQLQQYR 1811
Query: 4433 QQLDGALRQAKGFHGEIEDLQQWLTDTERHL--LASKPLGGLPETAKEQLNVHMEVCAAF 4490
+Q+ + + + L+ L +R + L K + E + + + E+
Sbjct: 1812 EQMQQGQHMEANHYQKCQKLEDELIAQKREVENLKQKMDQQIKEHEHQLVLLQCEIQKKS 1871
Query: 4491 EAKEETYK--------------SLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETK 4536
AK+ T+K L + L P+S Q+ L+EKW+ +
Sbjct: 1872 TAKDCTFKPDFEMTVKECQHSGELSSRNTGHLHPTPRSPLLRWTQEPQPLEEKWQHRVVE 1931
Query: 4537 LNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNV 4574
++ + + +E S Q + + +Q L +
Sbjct: 1932 QIPKEVQFQPP-GAPLEKEKSQQCYSEYFSQTSTELQI 1968
Score = 77.8 bits (190), Expect = 3e-13
Identities = 229/1247 (18%), Positives = 500/1247 (40%), Gaps = 199/1247 (15%)
Query: 2695 YQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQ---QLETAQKMKQEIQQEKKQIKVAQ 2751
Y S +R++ +L + +++L + D +++ ++ +K+K+E+++ K +
Sbjct: 742 YISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTIT 801
Query: 2752 ALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRD 2811
CE+ + L +L +L++ V + ++ L++ + + ++
Sbjct: 802 NKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTV----NLVLKNTQA 857
Query: 2812 FQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYE---------KTIA 2862
+A + + + + + A + +E+LI K + + + ++ K I+
Sbjct: 858 AEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAIS 917
Query: 2863 EGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALK-YKEQVETL 2921
+ K + + + + + + W + Q+ R L E + K+LK Y++ L
Sbjct: 918 DEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDL-EGIGKSLKYYRDTYHPL 976
Query: 2922 WPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEI 2981
WI + + +I+ EN K+L +++Q L+S E+
Sbjct: 977 DDWIQQVETTQRKIQ--------ENQPENSKTLATQLNQQ-----------KMLVSEIEM 1017
Query: 2982 DKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQK-FKEFQEVSKESKRQLQCAKEQLD 3040
K+ DE + ++ K + L+ MT + + Q+ S +R++Q + + L
Sbjct: 1018 -KQSKMDECQKYAEQYSATV-----KDYELQTMTYRAMVDSQQKSPVKRRRMQSSAD-LI 1070
Query: 3041 IHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLV---VEASDSKGTSDVLL 3097
I + + + +T++ Q +K D KRL ++ + E S+ SD+L
Sbjct: 1071 IQEFMDLRTRYTALVTLM------TQYIKFAGDSLKRLEEEEIKRCKETSEHGAYSDLLQ 1124
Query: 3098 QVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRD 3157
+ + E+S L+ ++ E + + E+ Q + ++EL + +
Sbjct: 1125 RQKATVLENSKLTGKISE--------------LERMVAELKKQKSRVEEELPKVREAAEN 1170
Query: 3158 AETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKR-DLEALSKQC 3216
E ++Q+ L+K+ A + + ++ E +L +++ +EA +K+
Sbjct: 1171 -ELRKQQRNVEDISLQKIRAESEAKQYRRELETIVREKEAAERELERVRQLTIEAEAKRA 1229
Query: 3217 NKLLDRAQAREEQVEGTI-KRLEEFYSKLKEFS---ILLQKAEEHEESQGPVGMETETIN 3272
+ R + E T +R E + K K+ S + QK + EE + E E +
Sbjct: 1230 AVEENLLNFRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRDNEEELLK 1289
Query: 3273 --QQLNMFKVFQKEEIEPLQGKQQDV-----------------NWLGQGLIQSAAKSTST 3313
+Q+ FQK+ E ++Q + N L I A +
Sbjct: 1290 LIKQMEKDLAFQKQVAEKQLKEKQKIELEARRKITEIQYTCRENALPVCPITQATSCRAV 1349
Query: 3314 QGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQK 3373
GL+ + D K+ A+ Q + L R + L++ ++ +L +K
Sbjct: 1350 TGLQQEHD----------KQKAEELKQQVDELTAANRKAEQDMRELTYELNALQL---EK 1396
Query: 3374 PPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLD 3433
S E + +LL+ LD+ +T+ +K E E+ + A+K +QL L
Sbjct: 1397 TSSEE---------KARLLKDKLDETNNTLRCLKLELER----KDQAEK-GYSQQLRELG 1442
Query: 3434 SRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEE 3493
+ KAE ++ + + + + LE LN EK G +++
Sbjct: 1443 RQLNQTTGKAEEAMQEASDLKKIKRNYQLELESLNH-----EK--------GKLQREVDR 1489
Query: 3494 QIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQ-EKS 3552
H E +I + N +H S R++K++ + ++ + +++ Q EKS
Sbjct: 1490 ITRAHAVAEKNIQHLNSQIH------------SFRDEKELERLQICQRKSDHLKEQFEKS 1537
Query: 3553 HSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQE 3612
H +LLQ A+ D+++ +N E ++ +++ Q E L +Q +E +++ +
Sbjct: 1538 H--EQLLQN--IKAEKENNDKIQRLNEELEKSNECAEMLKQ--KVEELTRQNNETKLMMQ 1591
Query: 3613 DILLRKQNV---DQALLNGLELLK-QTTGDEVLIIQDKLEAIKARYKDITKLSTDV---A 3665
I +N+ Q + E LK Q G +D+L + TK D
Sbjct: 1592 RIQAESENIVLEKQTIQQRCEALKIQADG-----FKDQLRSTNEHLHKQTKTEQDFQRKI 1646
Query: 3666 KTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGE-EASQAQMRPKELKKEAK 3724
K LE+ L ++ L S ++ C + ++ E + L E AS+ + R E K + +
Sbjct: 1647 KCLEEDLAKSQNLVSEFKQKCD-QQNIIIQNTKKEVRNLNAELNASKEEKRRGEQKVQLQ 1705
Query: 3725 NNKA--LLDSLNEVSSAL-LELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAI 3781
+ L + L +V L L+ + + + E++ +++ ++ +K+E++
Sbjct: 1706 QAQVQELNNRLKKVQDELHLKTIEEQMTHRKMVLFQEESGKFKQSAEEFRKKMEKL---- 1761
Query: 3782 LRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQ--LQVQKTFTMEILRHKDII 3839
E ITE + + L + L+Q+ + AQ ++ +T E+ R
Sbjct: 1762 -----------MESKVITENDISGIRLDFVSLQQENSRAQENAKLCETNIKELERQLQQY 1810
Query: 3840 DDLVKSGHKIMT-------------ACSEEEKQSMKKKLDKVLKNYD 3873
+ ++ G + + E +++K+K+D+ +K ++
Sbjct: 1811 REQMQQGQHMEANHYQKCQKLEDELIAQKREVENLKQKMDQQIKEHE 1857
Score = 72.8 bits (177), Expect = 9e-12
Identities = 273/1451 (18%), Positives = 559/1451 (38%), Gaps = 183/1451 (12%)
Query: 3555 RSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDI 3614
+S LL Q L +I + +L+NW++E+ +L + W S+L + E
Sbjct: 264 KSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTE---------W--GSDLPSV-ESH 311
Query: 3615 LLRKQNVDQALLNGLELLKQTTGDEV-------LIIQDKLEAIKARYKDITKLSTDVAKT 3667
L +NV +A+ LK+ E+ L +KL ++++Y + S + +
Sbjct: 312 LENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERH 371
Query: 3668 LEQALQLARRLHSTHEELCTWLDKVEVELLSYE-----TQVLKGEEASQAQMRPKELKKE 3722
L+ R +T+E + WL++ E E ++Y+ T + + ++ MR EL ++
Sbjct: 372 LDTLHNFVSR--ATNELI--WLNEKEEEEVAYDWSERNTNIARKKDYHAELMR--ELDQK 425
Query: 3723 AKNNKALLD----SLNEVSSALLELVPWRAR------------EGLEKMVAEDNERYRLV 3766
+N K++ + L E A L + +RA + +E+ + E+ +
Sbjct: 426 EENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFF 485
Query: 3767 SDT--ITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQV 3824
+D T + + AI R D++ + + + + ++ M + L+ T A L +
Sbjct: 486 NDAKEATDYLRNLKDAIQRKYSCDRS--SSIHKLEDLVQESMEEKEELLQYKSTIANL-M 542
Query: 3825 QKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDK-VLKN------YDTICQ 3877
K T+ L+ ++ D +K+ I C + + K D+ VL N + I
Sbjct: 543 GKAKTIIQLKPRN-SDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISP 601
Query: 3878 INSERYLQL---------ERAQSLVNQFWETYEE-LWPWLTETQSIISQLPAPALEYETL 3927
+E + + A L N+ + Y+ L W ++ S + L E
Sbjct: 602 TGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEID 661
Query: 3928 RQQQEEHRQLRELI-AEHKPHIDKMNKTGPQLLELS------PGEGFSIQEKYVAADTLY 3980
R + ++ ++ EH+ + + LE S G + EK V +
Sbjct: 662 RIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEV---NVC 718
Query: 3981 SQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKE--- 4037
Q +++ K A ++ S + ++ I LE +RL + E + + E
Sbjct: 719 KQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVF 778
Query: 4038 QISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIH 4097
+I+E + + ++E+L+ T+ + EE +++ + S ++ +L+ ++ ++
Sbjct: 779 RITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASS---SVPTLRSELNVVLQNMNQVY 835
Query: 4098 TLVEEREAKLLDV-------------MELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGID 4144
++ KL V ++L E C+ ++I + ++ I
Sbjct: 836 SMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLI--------- 886
Query: 4145 PSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPI--VKKSIDELNSAW 4202
S +KQ + + R+ L++EL + E+ E D K+ D+L W
Sbjct: 887 -STLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERW 945
Query: 4203 DSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDW---VDIAGGKLASMSPIGTDLETVKQ 4259
+++ +R+ LE ++ Y+D + DW V+ K+ P + +T+
Sbjct: 946 QNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQP--ENSKTLAT 1003
Query: 4260 QIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERI 4319
Q+ + K SE +Q +M+ AE V + + M + + DS ++
Sbjct: 1004 QLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKD------YELQTMTYRAMVDSQQKSP 1057
Query: 4320 INRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDP-KAIEIELAK----- 4373
+ R+ A L + +F A +T L+++ GD K +E E K
Sbjct: 1058 VKRRRMQSSADLIIQEFMDLRTRYTALVT----LMTQYIKFAGDSLKRLEEEEIKRCKET 1113
Query: 4374 -HHVLQNDVLAHQ-STVEAVNKAGNDLIE-----SSAGEEASNLQNKLEVLNQRWQNVLE 4426
H +D+L Q +TV +K + E + ++ S ++ +L + + +N L
Sbjct: 1114 SEHGAYSDLLQRQKATVLENSKLTGKISELERMVAELKKQKSRVEEELPKVREAAENELR 1173
Query: 4427 KTEQRKQQLD----GALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNV 4482
K ++ + + A +AK + E+E + + ER L QL +
Sbjct: 1174 KQQRNVEDISLQKIRAESEAKQYRRELETIVREKEAAEREL-----------ERVRQLTI 1222
Query: 4483 HMEV-CAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERK 4541
E AA E +++ +++ R + D +N+L+++ + +L ++
Sbjct: 1223 EAEAKRAAVEENLLNFRNQLEE-NTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKR 1281
Query: 4542 TKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNS 4601
EE L L + +D AE+ L + L + +I ++ N +
Sbjct: 1282 DNEEELLKLIKQME---KDLAFQKQVAEKQLKEKQKIELEARRKITEI-QYTCRENALPV 1337
Query: 4602 HREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAK 4661
+ T L+ KQ +K + + + K Q + E L+ +
Sbjct: 1338 CPITQATSCRAVTGLQQEHDKQKAEELKQQVDELTAANRKAEQDMRELTYELNALQLEKT 1397
Query: 4662 QFHEAWSKLMEWLEESEKSLDS-ELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNR 4720
E L + L+E+ +L +LE+ K Q +E + L TT +
Sbjct: 1398 SSEEKARLLKDKLDETNNTLRCLKLELERKDQAEKGYSQQLRELGRQLN------QTTGK 1451
Query: 4721 TGRSLKEKTSL----ADDNLKLDDMLSE---LRDKWDTICGKSVERQNKLEEALLFSGQF 4773
+++E + L + L+L+ + E L+ + D I + ++ F
Sbjct: 1452 AEEAMQEASDLKKIKRNYQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIHSF 1511
Query: 4774 TDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNL------IDNHKAFQKELGKRTSSVQA 4827
D + + + + ++Q L+ N+ D + +EL K +
Sbjct: 1512 RDEKELERLQICQRKSDHLKEQFEKSHEQLLQNIKAEKENNDKIQRLNEELEKSNECAEM 1571
Query: 4828 LKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHA 4887
LK+ EL + + K+ MQ + E + + Q R EA QA+ F + +
Sbjct: 1572 LKQKVEELTRQNNE----TKLMMQRIQAESENIVLEKQTIQQRCEALKIQADGFKDQLRS 1627
Query: 4888 LLEWLAEAEQT 4898
E L + +T
Sbjct: 1628 TNEHLHKQTKT 1638
Score = 53.9 bits (128), Expect = 4e-06
Identities = 166/831 (19%), Positives = 325/831 (39%), Gaps = 149/831 (17%)
Query: 4188 KPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASM 4247
KP++K S+ + N + +N + +Q + + D +Q D + G L S+
Sbjct: 260 KPLLKSSLLDQNLTEEEINMKF----------VQDLLNWVDEMQVQLDRTEW-GSDLPSV 308
Query: 4248 SPIGTDLETVKQQIEELKQFKSEAYQQQIEM------------ERLNHQ-AELLLKKVTE 4294
+ + V + IEE + EA +I+M RL Q A+LL +
Sbjct: 309 ESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQ 368
Query: 4295 ESDKHTVQDPLMEL--KLIW-DSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTE 4351
E T+ + + +LIW + EE + +A + HA EL+ L E
Sbjct: 369 ERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHA--ELMRELDQKE 426
Query: 4352 GLL------SEQKPVGGDPKAIEIEL------------------AKHHVLQNDVLAH--Q 4385
+ +EQ + P + IE + H+ +N
Sbjct: 427 ENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFN 486
Query: 4386 STVEAVNKAGN--DLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAK 4443
EA + N D I+ + S+ +KLE L Q E+ Q K + + +AK
Sbjct: 487 DAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAK 546
Query: 4444 GFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHM--EVCAAFEAKEETYKSLM 4501
+Q +++ L S P+ + + + ++ ++ E A + +K +
Sbjct: 547 TI------IQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVIS 600
Query: 4502 QKGQQMLA-----RCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHN 4556
G + + P + +D N +++++++V T +E ++ +
Sbjct: 601 PTGNEAMVPSVCFTVPPPNKEAVDL-ANRIEQQYQNVLTLWHESHINMKSVV-------- 651
Query: 4557 SLQDFINWLTQAEQTLNVASRPSLI--------------LDTVLFQIDEHKVFANEVNSH 4602
S IN + + + NVAS +++ + L E +VF+ +
Sbjct: 652 SWHYLINEIDRIRAS-NVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQ 710
Query: 4603 REQIIELDKTGTH--LKYFSQKQDVVLIKNLLIS----VQSRWEKVVQRLVERGRSLDDA 4656
E+ + + K LK +++ + NL IS ++ R E RL+ + R+
Sbjct: 711 LEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRT---- 766
Query: 4657 RKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYD 4716
HE+ ++ E ++ L ELE D + T + +EF A SV
Sbjct: 767 PLERDDLHESVFRITE-----QEKLKKELERLKDD--LGTITNKCEEFFSQAAASSSV-- 817
Query: 4717 TTNRTGRSLKEKTSLADDNL-KLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTD 4775
+L+ + ++ N+ ++ M S DK T+ ++ +N T
Sbjct: 818 ------PTLRSELNVVLQNMNQVYSMSSTYIDKLKTV---NLVLKN------------TQ 856
Query: 4776 ALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQAL------- 4828
A +AL+ LY E +L E++ V D + + NLI K ++ E+ ++ AL
Sbjct: 857 AAEALVK-LY--ETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKA 913
Query: 4829 KRSARELIEGSRD---DSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVV 4885
K + E+ + ++ D W K + +L RW+ V ++ LE + + +
Sbjct: 914 KAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTY 973
Query: 4886 HALLEWLAEAEQTLR-FHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNK 4935
H L +W+ + E T R P++ L T ++Q K + ++E K++++++
Sbjct: 974 HPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDE 1024
Score = 40.8 bits (94), Expect = 0.038
Identities = 46/200 (23%), Positives = 86/200 (43%), Gaps = 16/200 (8%)
Query: 4777 LQALIDWLYRVEPQLAEDQPVHG-DIDLVMNLIDNHKAFQKELGKRTSSVQALKRSAREL 4835
+Q L++W+ ++ QL D+ G D+ V + ++NHK + + + SS++ K S ++
Sbjct: 282 VQDLLNWVDEMQVQL--DRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQM 339
Query: 4836 IEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEA 4895
++ +K+ E R E+ A ++ E L F S L WL E
Sbjct: 340 -------TAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEK 392
Query: 4896 EQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTI 4955
E+ + + + R D H E M++L++K + + + +L HP +T
Sbjct: 393 EEEEVAYDWSERNTNIARKK-DYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLT-- 449
Query: 4956 KHWITIIRARFEEVLAWAKQ 4975
I RA + +W Q
Sbjct: 450 ---IEAYRAAMQTQWSWILQ 466
Score = 40.0 bits (92), Expect = 0.064
Identities = 147/728 (20%), Positives = 270/728 (37%), Gaps = 111/728 (15%)
Query: 4402 SAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTER 4461
S+G E ++LQ L+++ R K + LD L + + ++DL W+ + +
Sbjct: 242 SSGVEPNSLQT-LKLMQIR------KPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQV 294
Query: 4462 HLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQ 4521
L ++ LP + + L H V A E E + K QM A + +
Sbjct: 295 QLDRTEWGSDLP-SVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKL-- 351
Query: 4522 DINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLI 4581
+ ES KL E L+ F + + + WL + E+
Sbjct: 352 ------HRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE----------- 394
Query: 4582 LDTVLFQIDEHKV-FANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKN---------L 4631
+ V + E A + + H E + ELD+ ++K + + +L++N
Sbjct: 395 -EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAY 453
Query: 4632 LISVQSRWEKVVQ--RLVERG---------------------RSLDDA--RK----RAKQ 4662
++Q++W ++Q + VE+ R+L DA RK R+
Sbjct: 454 RAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSS 513
Query: 4663 FHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTG 4722
H+ + E +EE E+ L + IAN K KT + Q K K S+
Sbjct: 514 IHKLEDLVQESMEEKEELLQYKSTIANLMGKAKT-IIQLKPRNSDCPLKTSIPIKAICDY 572
Query: 4723 RSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFT--DALQAL 4780
R + E T DD L + + R KW I EA++ S FT +
Sbjct: 573 RQI-EITIYKDDECVLAN--NSHRAKWKVISPTG-------NEAMVPSVCFTVPPPNKEA 622
Query: 4781 IDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGK-RTSSVQALK---------- 4829
+D R+E Q + + + M + + E+ + R S+V ++K
Sbjct: 623 VDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQV 682
Query: 4830 -RSARELIEGSRDDSSWVKV-QMQELSTRWETVCALSISKQTRLEAALRQAEE------F 4881
+ + E +DS +V +++ + V Q L++A R+ +E +
Sbjct: 683 LSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLY 742
Query: 4882 HSVVHALLEWLAEAEQTLRFHGVLPDDEDALRT---LIDQHKEFMKKLEEKRAELNKATT 4938
S V + L E L P + D L I + ++ K+LE + +L T
Sbjct: 743 ISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITN 802
Query: 4939 MGDTVLA-ICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLAS---ALAGLIAKQELL 4994
+ + S+ T++ + ++ +V + + + +L + L A + L+
Sbjct: 803 KCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALV 862
Query: 4995 EALLAWLQWAETTLTDKDK-----EVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTK 5049
+ L E + DK+ + Q EV +E+ + + D++ K
Sbjct: 863 KLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFK 922
Query: 5050 TYKRRAAD 5057
TYK R D
Sbjct: 923 TYKERDLD 930
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 861 bits (2224), Expect = 0.0
Identities = 637/2272 (28%), Positives = 1151/2272 (50%), Gaps = 200/2272 (8%)
Query: 641 EEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKI 700
E+ ++++QDLL WV+E Q ++D EWG DLPSVE+ L +H+ +H++IEEF + ++ A+
Sbjct: 518 EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS 577
Query: 701 SEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE 760
E Q++ + Y + L RL+ QYAKLLN+S+ + R L++LH+FV+ AT EL+WLNEKEE
Sbjct: 578 DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE 637
Query: 761 EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR 820
EEV +DWS+RNTN+ KK+ ++ LMREL+ KE+ IK +Q ++LL E+HPAR T+E+++
Sbjct: 638 EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 697
Query: 821 AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSI 880
AA+QTQWSW+LQLC C+E H+KEN AYF+FF+D +EA L+ L++A++RKYSCDRS+++
Sbjct: 698 AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATV 757
Query: 881 HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ 940
+LEDL+Q++ +EKE+L +YK ++ L +AK ++QLKPR+ P++ +P+ A+CDY+Q
Sbjct: 758 TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 817
Query: 941 IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ 1000
+E+T++K DEC L + + WKV+S +G+EA VPSVCF VPPPN+EA + R+E Q+Q
Sbjct: 818 VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ 877
Query: 1001 NVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFL 1060
++TLWH+ H++MKS+++W L ++ IR+ ++A+ +T+ P E +Q L +L+ ++ FL
Sbjct: 878 ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 937
Query: 1061 EDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLE 1120
DSQ++ F D E+E C +YQ+LL+S E+ QEES ISE+++IRL+LE
Sbjct: 938 RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE 997
Query: 1121 NCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAAS 1180
CE R + ++R PL+++ E RI EQ+K + E+E L + ++ + E+ + S
Sbjct: 998 ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1057
Query: 1181 SSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEA 1240
+ PTLRSEL + L + QV S+S+ Y++KLKT++LV++ TQ AE +++ +E +L E +A
Sbjct: 1058 PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1117
Query: 1241 VIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWH 1300
V A +E ++LK+ R++ + ++ F AL DEL+ A+ + + + + + ERD++ +
Sbjct: 1118 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1177
Query: 1301 KEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQ 1360
+E+ QL+ERWQ V Q D R R+LE +G+ L+YYR++ PL W+Q Q +IQ
Sbjct: 1178 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1237
Query: 1361 PENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQ 1420
+S+ + QL Q++ L+ EIE K++ECQ++A+QY +KDYELQ +TY+A ++
Sbjct: 1238 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLE-PV 1296
Query: 1421 KSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKK 1480
SP K+ ++QS ++ +IQE++DLRT Y+ L TL +QYIKF ++L+R+EEEE+ E+++
Sbjct: 1297 ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRA 1356
Query: 1481 E------HVEKAKELQKWVSNISKTLK-DAEKAGKPPFSKQKISSEEISTKKEQLSEALQ 1533
E VE A E Q+ ++ K AE+ K Q+ EE+ ++E +A Q
Sbjct: 1357 EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAK---ELQQRMQEEVVRREEAAVDAQQ 1413
Query: 1534 TIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKI-V 1592
++ ++++++ L++S +Q + ++ S +++EE+I V
Sbjct: 1414 ----------------QKRSIQEELQQLRQSSEAEIQAKARQAEAAERS-RLRIEEEIRV 1456
Query: 1593 AERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQ--EELQKDMQGS 1650
Q E E+ +G + G +A E +K Q+++ E L++ +Q
Sbjct: 1457 VRLQLEATERQRGGAE----------GELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1506
Query: 1651 AQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVT 1710
+Q + + +K E ++ +AL Q L E +++ E+ + Q++ E + V
Sbjct: 1507 SQRKRQAEVELASRVKAEAEAAREKQRAL--QALEELRLQAEEAERRLRQAEVERARQVQ 1564
Query: 1711 TAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDG 1770
A+ ET + +A +L+ + L ++ A + ++ E+ Q+ +
Sbjct: 1565 VAL--ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ--QQAEA 1620
Query: 1771 KSAIGE-EDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQ 1829
+ A E E E+ L+ + ++ E + QQ +A+ EK + A+
Sbjct: 1621 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK----------QKEEAE 1670
Query: 1830 VLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEF 1889
++G+ EE+ Q+ + E ++ + LAE + +L + ++EL + A+ +
Sbjct: 1671 REARRRGK---AEEQAVRQRELAEQELEKQRQLAEGTAQQRL--AAEQELIRLRAETEQG 1725
Query: 1890 EHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAK 1949
E Q E+EL L+ A ++++ ++ + ++ + S R E ++
Sbjct: 1726 EQQRQLLEEELARLQREA------AAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1779
Query: 1950 SCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCG 2009
S S++ +++ A R+L R R+L + ++ D + +A
Sbjct: 1780 STSEKSKQRLEAEAGR---FRELAEEAARLRALAEEAKRQRQLAEE--DAARQRAEAERV 1834
Query: 2010 LLAGLQAC-EATASKHLSEPIAVDPKNLQ----RQLEETKALQGQISSQQVAVEKLKKTA 2064
L L A EAT K +E IA+ K + R+L E +A Q + +Q A K
Sbjct: 1835 LAEKLAAIGEATRLKTEAE-IALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHK----- 1888
Query: 2065 EVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEML 2124
D L + L+ G ED + + E++ L+++ ++
Sbjct: 1889 ---ADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEI-------LALKASFEKAA 1938
Query: 2125 DWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDP 2184
G E L E G++ N+ +D + E + A RQ + A E+ ++ E
Sbjct: 1939 --AGKAELEL-ELGRIRSNA---EDTLRSKEQAELE-AARQRQLAAEEERRRREAE---- 1987
Query: 2185 STASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALT 2244
+ K L+A EA+ + K L ++E LK KVE L E+ + + Q
Sbjct: 1988 ------ERVQKSLAAE-EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ 2040
Query: 2245 EVDVPGKDVTE------LSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLE 2298
E E + Q QE + + L+ L + +++A V +
Sbjct: 2041 EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARV-Q 2099
Query: 2299 KTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGA 2358
++ +++E+ + K+ A Q + A K K +E ++ Q +
Sbjct: 2100 AEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQ 2159
Query: 2359 EDLGKS-LEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLN 2417
+ + +E KK E+ + ++++ ++ L T K + + L
Sbjct: 2160 KQAADAEMEKHKKFAEQTLRQKAQVEQ----ELTTLRLQLEETDHQKNL--LDEELQRLK 2213
Query: 2418 GEGTATNTEEFWANKGLTSIKKDMTDISH-----GYEDLGLLLKDKIAELNTKLSKLQKA 2472
E T + + L S++ M ++S E+ L+L+DK NT+ +
Sbjct: 2214 AEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKD---NTQ----RFL 2266
Query: 2473 QEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQE---L 2529
QEE+ M Q ++ + + Q+ A A + +Q E LK+ + VQE L
Sbjct: 2267 QEEAEKMKQVAEEAARLSVAAQEA-ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2325
Query: 2530 KDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQ-TVE 2588
K + ELL++ + + ++ +L D++Q ++ + FQ T+E
Sbjct: 2326 KAE-AELLQQQKELAQ---------------EQARRLQEDKEQMAQQLAEETQGFQRTLE 2369
Query: 2589 AQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILS 2648
A+ ++ L ++ + +++++ + E + + + E+ +
Sbjct: 2370 AERQRQL------------------EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE 2411
Query: 2649 RPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSD 2708
GE + ++ + Q + Q + + +AI + + + L+
Sbjct: 2412 EIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ------- 2464
Query: 2709 LDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCED----LSALVKEE 2764
+ KL + Q L+ Q ++Q EK + + E L L ++E
Sbjct: 2465 -EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDE 2523
Query: 2765 YLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQN 2824
KA+ R+ + + + +EQ+ + V ++ A H+ ++ R Q L ++++
Sbjct: 2524 VAKAQQLREEQ--QRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRR 2581
Query: 2825 KSHPISA--------KLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLL 2868
+ + A +L +LE + S+ +TA KT+ G + L
Sbjct: 2582 QQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDAL 2633
Score = 564 bits (1454), Expect = e-160
Identities = 274/460 (59%), Positives = 366/460 (79%), Gaps = 5/460 (1%)
Query: 65 AVLRIA----DERDKVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEVLSGDT 120
AVLR + DERD+VQKKTFTKW+N+HL+K ++H++DLYEDLRDGHNLISLLEVLSGD+
Sbjct: 28 AVLRASEGKKDERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDS 87
Query: 121 LPREKGRMRFHRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQIS 180
LPREKGRMRFH+LQNVQIALDYL+ RQVKLVNIRNDDI DGNPKLTLGLIWTIILHFQIS
Sbjct: 88 LPREKGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQIS 147
Query: 181 DIHVTGESEDMSAKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLIDM 240
DI V+G+SEDM+AKE+LLLW+Q+ EGY G+RC+NFT+ WRDG+LFNAIIH+++P LIDM
Sbjct: 148 DIQVSGQSEDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDM 207
Query: 241 NTVAVQSNLANLEHAFYVAEK-IGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAFPKVPE 299
N V Q+NL NL+ AF VAE+ +GV RLLDPEDVDV PDEKS+ITYVSSLYDA P+VP+
Sbjct: 208 NKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPD 267
Query: 300 GGEGIGANDVEVKWIEYQNMVNYLIQWIRHHVTTMSERTFPNNPVELKALYNQYLQFKET 359
+G+ AN+++++W EY+ +V L+QW+RHH ER FP++ E++ L++Q+L+FKE
Sbjct: 268 VQDGVRANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEM 327
Query: 360 EIPPKETEKSKIKRLYKLLEIWIEFGRIKLLQGYHPNDIEKEWGKLIIAMLEREKALRPE 419
E+P KE +K++ K +Y+ LE ++ G++K+ GYHP D+EKEWGKL +A+LEREK LR E
Sbjct: 328 ELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSE 387
Query: 420 VERLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECEN 479
ERLE LQ+I ++Q ++ +CE++L A LQSD + L +G Q E+ + + ++
Sbjct: 388 FERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADS 447
Query: 480 LLRQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNE 519
++R DVQ L DG++ Q +Q+ +RV +L + ++A+R E
Sbjct: 448 MIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTE 487
Score = 111 bits (277), Expect = 2e-23
Identities = 355/1874 (18%), Positives = 725/1874 (38%), Gaps = 306/1874 (16%)
Query: 2676 GQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQK 2735
G S + Q++ + Q +S + +L D+ +L + + H + E A++
Sbjct: 959 GSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARE 1018
Query: 2736 MKQEI-QQEKKQIKVA---------QALCEDLSALVKEEYLKAELSRQLEGILKSFKDVE 2785
Q I +Q+K Q +V A E + AL + L +LE L + V
Sbjct: 1019 CAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVR 1078
Query: 2786 QKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKD 2845
+ +++ L++ Q +A + KE Q + A L LE+ K
Sbjct: 1079 SLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQ----AVPATLPELEAT----KA 1130
Query: 2846 FSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQ----------------LNTIKTN 2889
K L AQ+ + T + L + +G+++ +LQ + +
Sbjct: 1131 SLKKLRAQAEAQQPTF---DALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLER 1187
Query: 2890 WDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFC--LDPAEGENS 2947
W Q R+ +L++ + Y+E + L W+ + E+I+ D
Sbjct: 1188 WQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQ 1247
Query: 2948 IAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSK 3007
+ + ++L +E+++H VE A ++ K
Sbjct: 1248 LRQEQALLEEIERHGEKVEECQRFAKQYINAI---------------------------K 1280
Query: 3008 KFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQA 3067
+ L+ +T K + S K ++Q E + I + + + + ++ T+ K +
Sbjct: 1281 DYELQLVTYKAQLEPVASPAKKPKVQSGSESV-IQEYVDLRTHYSELTTLTSQYIKFISE 1339
Query: 3068 LKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVET-IAQEHSTLSQQVDEKCSFLETKLQG 3126
+++ +RLA+ E + + L+ + +A+ H+ Q + + L+ ++Q
Sbjct: 1340 TLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ- 1398
Query: 3127 IGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKET-IKAFLKKLEALMASNDNA 3185
E+ + D + + + L++ E I+A ++ EA S
Sbjct: 1399 --------EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRI 1450
Query: 3186 NKTCKMM-LATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKL 3244
+ +++ L E T G + +L+AL +AR E+ E ++ +E +L
Sbjct: 1451 EEEIRVVRLQLEATERQRGGAEGELQAL-----------RARAEEAEAQKRQAQEEAERL 1499
Query: 3245 KEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLI 3304
+ + +ESQ E E ++ K E E + KQ+ + L + +
Sbjct: 1500 RR--------QVQDESQRKRQAEVELASRV--------KAEAEAAREKQRALQALEELRL 1543
Query: 3305 QSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVD 3364
Q+ + L + +RA Q+Q AL
Sbjct: 1544 QAEEAE-----------------RRLRQAEVERARQVQVAL------------------- 1567
Query: 3365 TEELVANQKPPSAEFKVVKAQIQEQKL-LQRLLDDRKSTVEVIKREGEKIATTAEPADKV 3423
Q+ AE + +A E+ L+R L + V ++ E E+ A A++
Sbjct: 1568 ----ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERA 1623
Query: 3424 KILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEP 3483
+ + L RW+ N+A Q E VAQQ + L + EK+ E
Sbjct: 1624 REEAEREL--ERWQLKANEALRLRLQAEE---VAQQ-----KSLAQ--AEAEKQKEEAER 1671
Query: 3484 IGTQASKLEEQIAQHKALEDDIINHNKHLHQAVS---IGQSLKVLSSREDKDMVQSKLDF 3540
+ K EEQ + + L + + + L + + + +++ R + + + +
Sbjct: 1672 EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL 1731
Query: 3541 SQVWYIEIQEKSHSRSELLQQALCN-AKIFGEDEVELMNWLN--EVHDKLSKLSVQDYST 3597
+ +Q ++ + ++ Q+ AK+ E EV L + E S+ S Q
Sbjct: 1732 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1791
Query: 3598 EG-----LWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKA 3652
E L ++ + LR L E+ ++Q ++ + +Q E ++ +KL AI
Sbjct: 1792 EAGRFRELAEEAARLRALAEEAKRQRQLAEE------DAARQRAEAE-RVLAEKLAAIG- 1843
Query: 3653 RYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQA 3712
+ T+L T+ L++ RL E+ ++E + ++ + E A
Sbjct: 1844 ---EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI----EERLA 1896
Query: 3713 QMRPKELKKEAKNNKALL-DSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTIT 3771
Q+R K E + K L+ D+L + E++ +A EK A E
Sbjct: 1897 QLR-KASDSELERQKGLVEDTLRQRRQVEEEILALKA--SFEKAAAGKAEL--------- 1944
Query: 3772 QKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTME 3831
E++ +RS D E + + ++ ++ + E+ + A+ +VQK+ E
Sbjct: 1945 ----ELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEE---ERRRREAEERVQKSLAAE 1997
Query: 3832 ---ILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLE- 3887
+ K ++++ + K+ EE + ++++ ++ + Q +++ LQ E
Sbjct: 1998 EEAARQRKAALEEVERLKAKV------EEARRLRERAEQESARQLQLAQEAAQKRLQAEE 2051
Query: 3888 RAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPH 3947
+A + Q E +EL L + QS++ QL A E R+ EE + R
Sbjct: 2052 KAHAFAVQQKE--QELQQTLQQEQSVLDQLRGEA---EAARRAAEEAEEARVQAEREAAQ 2106
Query: 3948 IDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQST----- 4002
+ + +L + + + + + AA+ L + +++ +RA A A+ Q
Sbjct: 2107 SRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAE 2166
Query: 4003 -QFHDK-----------IDQILESLE-RIVERLRQPPSISAEVEKIKEQISENK------ 4043
+ H K ++Q L +L ++ E Q + E++++K + +E
Sbjct: 2167 MEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQV 2226
Query: 4044 -----NVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHT 4098
+V V ME+L L ++ +I R DKD + + +Q++ ++M + E
Sbjct: 2227 EEELFSVRVQMEELSKLKARIEAENRALILR----DKDNTQRFLQEEAEKMKQVAEEAAR 2282
Query: 4099 L-VEEREAKLLDVMELAEKFWCDHMSLIVT-IKDTQDFIRDLEDPGIDPSVVKQQQEAAE 4156
L V +EA L +LAE+ +L +K+ +++ + +++QQ+E A+
Sbjct: 2283 LSVAAQEAARL--RQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ 2340
Query: 4157 TIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKL 4216
E+ LQE+ + ++ E + + E + +A + ++ ++
Sbjct: 2341 ---EQARRLQEDKE-------QMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKL-RV 2389
Query: 4217 EEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQI 4276
E +A + ++ Q + G KL + T+ Q +E I
Sbjct: 2390 AEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE-------------I 2436
Query: 4277 EMERLNHQAELLLKKVTE-ESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQ 4335
+ ++ +H AE L + + E E +K +Q E KL+ EE +Q +L AL Q
Sbjct: 2437 QRQQSDHDAERLREAIAELEREKEKLQQ---EAKLLQLKSEEMQTVQQEQLLQETQALQQ 2493
Query: 4336 FQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEI----ELAKHHVLQNDVLAHQSTVEAV 4391
++L+ + LL ++ + + +E E+AK L+ + Q +E
Sbjct: 2494 ---------SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQE 2544
Query: 4392 NKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIED 4451
+ L+ S EEA Q++ E +R Q L++ EQ+++Q + L + + + +
Sbjct: 2545 RQR---LVASM--EEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEE---NQRLRE 2596
Query: 4452 LQQWLTDTERHLLA 4465
Q L + R LA
Sbjct: 2597 QLQLLEEQHRAALA 2610
Score = 94.0 bits (232), Expect = 4e-18
Identities = 353/1847 (19%), Positives = 705/1847 (38%), Gaps = 283/1847 (15%)
Query: 3201 DLVGIKRDLEALSKQCNKLLDRAQ--AREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHE 3258
D + +R+ + S +LL + A+EE R + S+LK+ + L+ E
Sbjct: 950 DRLMAEREYGSCSHHYQQLLQSLEQGAQEES------RCQRCISELKDIRLQLEACETRT 1003
Query: 3259 ESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAK--------- 3309
+ + ++ E + + I Q Q +V LG+G+ + +A+
Sbjct: 1004 VHRLRLPLDKEPARECA--------QRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPE 1055
Query: 3310 -STSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEEL 3368
S + L +L+ + + + A +L+ L Q A E L + +E
Sbjct: 1056 PSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEA 1115
Query: 3369 VA------NQKPPSAEFKVVKAQIQ-EQKLLQRLLDDRKSTVEVIKREGEKIATTAEPAD 3421
A + A K ++AQ + +Q L D+ + EV +R ++ +
Sbjct: 1116 QAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVE 1175
Query: 3422 KVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNC 3481
+ + ++++ L RW+A+L + + R R+LE + + + E+ +PL WL +R
Sbjct: 1176 RWR--ERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQI 1233
Query: 3482 EPIGTQASK-LEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDF 3540
+ + S+ + EQ+ Q +AL ++I H + + + + + +V K
Sbjct: 1234 QAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQL 1293
Query: 3541 SQVWYIEIQEKSHSRSELLQQALCNAKI-FGEDEVELMNWLNEVHDKLSKLSVQDYSTEG 3599
V + K S SE + Q + + + E ++ + + L ++ ++ E
Sbjct: 1294 EPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE- 1352
Query: 3600 LWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITK 3659
+Q++E R R V+ AL +L + Q K +A + + +
Sbjct: 1353 --QQRAEERE-------RLAEVEAALEKQRQLAEAHA-------QAKAQAEREAKELQQR 1396
Query: 3660 LSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKEL 3719
+ +V + E A+ ++ S EEL E E+ + K +A A+ +
Sbjct: 1397 MQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQA------KARQAEAAERSRLRI 1450
Query: 3720 KKEAKNNKALLDSL-NEVSSALLELVPWRAR----EGLEKMVAEDNERYRLVSDTITQKV 3774
++E + + L++ + A EL RAR E ++ E+ ER R +Q+
Sbjct: 1451 EEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRK 1510
Query: 3775 EEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILR 3834
+ + + AE E ++ L +L ++RL+ ++ +L+ E+ R
Sbjct: 1511 RQAEV------ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR-----QAEVER 1559
Query: 3835 HKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVN 3894
+ V+ + +E E QS + +E+ QLER+
Sbjct: 1560 ARQ-----VQVALETAQRSAEAELQSKRASF--------------AEKTAQLERS----- 1595
Query: 3895 QFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKT 3954
L E ++QL E E QQQ E + RE E + +++
Sbjct: 1596 ------------LQEEHVAVAQLRE---EAERRAQQQAEAERARE---EAERELERWQLK 1637
Query: 3955 GPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILES 4014
+ L L Q+K +A Q KE+ ++ A +A Q+ + + +Q LE
Sbjct: 1638 ANEALRLRLQAEEVAQQKSLAQAEAEKQ-KEEAEREARRRGKAEEQAVRQRELAEQELEK 1696
Query: 4015 LERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTD 4074
++ E Q ++AE E I+ + + E+ + L E R + A +
Sbjct: 1697 QRQLAEGTAQ-QRLAAEQELIRLRAETEQG-----EQQRQLLEEELARLQREAAAATQKR 1750
Query: 4075 KDISAKAVQDKLDQMVFIWENIHTLVEER----------EAKLLDVMELAEKFWCDHMSL 4124
+++ A+ + + + V + E R EA+ ELAE+ +
Sbjct: 1751 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE-----AAR 1805
Query: 4125 IVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQE------ELDIVI---NL 4175
+ + + R L + +Q+ EA + E++ + E E +I +
Sbjct: 1806 LRALAEEAKRQRQL----AEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEA 1861
Query: 4176 GSELIAACGEPDKPIVKKSIDE--------LNSAWDSLNKAWKDRIDK----LEEAMQAA 4223
+E + E D+ ++ ++E + L KA +++ +E+ ++
Sbjct: 1862 ENERLRRLAE-DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQR 1920
Query: 4224 VQYQDGLQAV-FDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQ---IEME 4279
Q ++ + A+ + A GK +G + + +Q + EA +Q+ E E
Sbjct: 1921 RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE 1980
Query: 4280 RLNHQAELLLKK--VTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQ 4337
R +AE ++K EE + L E++ + +EE R+ + + L Q
Sbjct: 1981 RRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ 2040
Query: 4338 HALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAH-QSTVEAVNKAGN 4396
A + L +QK E EL + + VL + EA +A
Sbjct: 2041 EAAQKRLQAEEKAHAFAVQQK---------EQELQQTLQQEQSVLDQLRGEAEAARRAAE 2091
Query: 4397 DLIES--SAGEEASNLQNKLEVLNQRWQNVLEKTEQ-----------RKQQLDGALRQAK 4443
+ E+ A EA+ + ++E + Q+ E+ + RK+ A R+A+
Sbjct: 2092 EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQ 2151
Query: 4444 GFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEET--YKSLM 4501
+ Q + E+H ++ +T +++ V E+ EET K+L+
Sbjct: 2152 AEQAALRQKQAADAEMEKHKKFAE------QTLRQKAQVEQELTTLRLQLEETDHQKNLL 2205
Query: 4502 QKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNE---RKTKLE-EALNLAMEFHNS 4557
+ Q L K+ T + + ++E+ SV ++ E K ++E E L + ++
Sbjct: 2206 DEELQRL----KAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDN 2261
Query: 4558 LQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLK 4617
Q F+ +AE+ VA + L + + A E + + + E K
Sbjct: 2262 TQRFLQ--EEAEKMKQVAEEAAR-LSVAAQEAARLRQLAEEDLAQQRALAE--------K 2310
Query: 4618 YFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSL-DDARKRAKQFHEAWSKLMEWLEE 4676
+K V L + ++ + E+ R L +D + A+Q E LE
Sbjct: 2311 MLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA 2370
Query: 4677 SEKSLDSELEIANDPDKIKTQLAQ--------HKEFQKSLGAKHSVYDTTNRTGRSLKEK 4728
+ +LE++ + +++K ++A+ ++ Q+ + + +RT + +EK
Sbjct: 2371 ERQ---RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEK 2427
Query: 4729 TSLAD-----------DNLKLDDMLSELRDKWDTICG-------KSVERQNKLEEALLFS 4770
+L D +L + ++EL + + + KS E Q +E LL
Sbjct: 2428 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLL-- 2485
Query: 4771 GQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKR 4830
Q T ALQ +L + L ++ + + + L + A ++L + Q
Sbjct: 2486 -QETQALQQ--SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2542
Query: 4831 SARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLE 4890
R+ + S +++ + + +E R + + +LE RQ EE
Sbjct: 2543 QERQRLVASMEEARRRQHEAEEGVRRKQ-------EELQQLEQQRRQQEEL--------- 2586
Query: 4891 WLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKAT 4937
LAE Q LR + L+ L +QH+ + EE A AT
Sbjct: 2587 -LAEENQRLR---------EQLQLLEEQHRAALAHSEEVTASQVAAT 2623
Score = 85.1 bits (209), Expect = 2e-15
Identities = 295/1541 (19%), Positives = 608/1541 (39%), Gaps = 226/1541 (14%)
Query: 3708 EASQAQMRPKELKKEAKNNKALLDSLN-------EVSSAL--------LELVPWRAREGL 3752
EA++A + K+L+ +A+ + D+L EV L +E+ WR R
Sbjct: 1126 EATKASL--KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRER--- 1180
Query: 3753 EKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIR 3812
VA+ ER++ V + E++ + + + ++AD +W+ + ++ + +
Sbjct: 1181 ---VAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1237
Query: 3813 LEQDQT-SAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQ--SMKKKLDKVL 3869
L Q QL+ ++ EI RH + +++ + + + A + E Q + K +L+ V
Sbjct: 1238 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA 1297
Query: 3870 KNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQ 3929
+ + QS + Y +L +E ++ SQ ETLR+
Sbjct: 1298 SP------------AKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIK--FISETLRR 1343
Query: 3930 QQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKK 3989
+EE R + AE + + ++ + +L+ + + A L +++E+V +
Sbjct: 1344 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1403
Query: 3990 RAVALDEAISQSTQFHDKIDQILESLERIVE-RLRQPPSISAEVEKIKEQISENKNVSVD 4048
R A +A Q +++ Q+ +S E ++ + RQ + +I+E+I
Sbjct: 1404 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR-------- 1455
Query: 4049 MEKLQPLYETLKQRG----EEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEERE 4104
+ +LQ L T +QRG E R+ + + + Q++ +++ + +E +
Sbjct: 1456 VVRLQ-LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLR------RQVQDESQ 1508
Query: 4105 AKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIRE-EID 4163
K +ELA + + + ++ Q ++ LE+ + Q +EA +R+ E++
Sbjct: 1509 RKRQAEVELASRVKAEAEAA----REKQRALQALEELRL------QAEEAERRLRQAEVE 1558
Query: 4164 GLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWD-SLNKAWKDRIDKLEEAMQA 4222
++ + + E E + + S E + + SL + EEA +
Sbjct: 1559 RARQ-----VQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERR 1613
Query: 4223 AVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLN 4282
A Q + +A + A +L + ++ Q EE+ Q KS A Q E E+
Sbjct: 1614 AQQQAEAERAREE----AERELERWQLKANEALRLRLQAEEVAQQKSLA---QAEAEKQK 1666
Query: 4283 HQAELLLKKVTEESDKHTVQDPLMELKLIWD-SLEERIINRQHKLEGALLALG------- 4334
+AE ++ + ++ Q L E +L L E ++ E L+ L
Sbjct: 1667 EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1726
Query: 4335 QFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKA 4394
Q + L+E LA L ++++ + +E ELAK +LA ++ E +++
Sbjct: 1727 QQRQLLEEELARLQREAAAATQKR------QELEAELAKVRAEMEVLLASKARAEEESRS 1780
Query: 4395 GNDL----IESSAG------EEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKG 4444
++ +E+ AG EEA+ L+ E ++ Q E +++ + + L +
Sbjct: 1781 TSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLA 1840
Query: 4445 FHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKG 4504
GE L+ TE + + E E+L + AF+ + ++ K
Sbjct: 1841 AIGEATRLK-----TEAEIALKEK-----EAENERLR-RLAEDEAFQRRRLEEQAAQHKA 1889
Query: 4505 --QQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFI 4562
++ LA+ K++++ +++ VE L +R+ EE L L F +
Sbjct: 1890 DIEERLAQLRKASDSELERQKG-------LVEDTLRQRRQVEEEILALKASFEKAAAG-- 1940
Query: 4563 NWLTQAEQTLNVASRPSLILDTV-------LFQIDEHKVFANEVNSHREQIIELDKTGTH 4615
+AE L + S DT+ L + ++ A E RE + K+
Sbjct: 1941 ----KAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAA 1996
Query: 4616 LKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLE 4675
+ ++++ L + V+RL + R+RA+Q E+ +L E
Sbjct: 1997 EEEAARQRKAAL-------------EEVERLKAKVEEARRLRERAEQ--ESARQLQLAQE 2041
Query: 4676 ESEKSLDSELEIANDPDKIKTQLAQHKE--FQKSLGAKHSVYDTTNRTGRSLKEKTSLAD 4733
++K L +E +K Q KE Q++L + SV D + + A+
Sbjct: 2042 AAQKRLQAE-------EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE 2094
Query: 4734 D-NLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLA 4792
+ ++ + ++ R + VE +L+++ Q QA + L + Q A
Sbjct: 2095 EARVQAEREAAQSR--------RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2146
Query: 4793 E-----DQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVK 4847
+Q ++ HK F ++ ++ + V+ + R +E + + +
Sbjct: 2147 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2206
Query: 4848 VQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPD 4907
++Q L + L + Q EE L+ EAE ++
Sbjct: 2207 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSK-----LKARIEAEN----RALILR 2257
Query: 4908 DEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFE 4967
D+D + + + E MK++ E+ A L+ A + + D + RA E
Sbjct: 2258 DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED--------LAQQRALAE 2309
Query: 4968 EVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALI 5027
++L K+ Q + A L A+ ELL+ Q L + +++ Q EE +
Sbjct: 2310 KML---KEKMQAVQEA-TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGF- 2364
Query: 5028 AEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSG 5087
Q +E ++Q ++ + K R A+ S Q+ + A R R A +
Sbjct: 2365 ---QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA----EEDAQRFRKQAEEIGEKL 2417
Query: 5088 SQTQIETKNPRVNLLVSKWQQVWLLALERRR------KLNDALDRLEELREFANFDFDIW 5141
+T++ T+ K V L ++R++ +L +A+ LE +E + +
Sbjct: 2418 HRTELATQ--------EKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL 2469
Query: 5142 RKKYMRWMNHKKSRVMDFFRRIDK----DQDGKITRQEFID 5178
+ K ++ +++ + + + ++D + R+ FI+
Sbjct: 2470 QLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE 2510
Score = 78.6 bits (192), Expect = 2e-13
Identities = 352/1885 (18%), Positives = 731/1885 (38%), Gaps = 251/1885 (13%)
Query: 3336 QRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRL 3395
QR +L+++ L L+ LL+W+ + + V + + V+AQ+ + L +
Sbjct: 512 QRRPELEDSTLRY------LQDLLAWVEENQHRVDGAEW-GVDLPSVEAQLGSHRGLHQS 564
Query: 3396 LDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGI-S 3454
+++ ++ +E + + +++ PA + L LD ++ LLN ++ R R LE + S
Sbjct: 565 IEEFRAKIERARSDEGQLS----PATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHS 620
Query: 3455 VVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQ 3514
VA E + WL E+ V + + + + + + AL ++ K + +
Sbjct: 621 FVAAATKELM-----WLNEKEEEEVGFD-WSDRNTNMTAKKESYSALMRELELKEKKIKE 674
Query: 3515 AVSIGQSL--KVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGED 3572
+ G L + +R + Q+ L W +LQ C
Sbjct: 675 LQNAGDRLLREDHPARPTVESFQAALQTQWSW-------------MLQLCCC-------- 713
Query: 3573 EVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQ-ALLNGLEL 3631
E H K + Q +S + + + +L+ LQE L RK + D+ A + LE
Sbjct: 714 --------IEAHLKENAAYFQFFS--DVREAEGQLQKLQE-ALRRKYSCDRSATVTRLED 762
Query: 3632 LKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDK 3691
L Q DE +++L K + +AK + +QL R H H
Sbjct: 763 LLQDAQDE----KEQLNEYKGHL-------SGLAKRAKAVVQLKPR-HPAHPMRGRLPLL 810
Query: 3692 VEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVS-SALLELVPWRARE 3750
+ E V KG+E + + K L S +E + ++ LVP +E
Sbjct: 811 AVCDYKQVEVTVHKGDECQLVG------PAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQE 864
Query: 3751 GLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGD 3810
E + + + LV T+ ++ ++L Q + SW T + L
Sbjct: 865 AQEAVTRLEAQHQALV--TLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKP--- 919
Query: 3811 IRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLK 3870
EQ Q L+ L ++ + D +G E++ +++
Sbjct: 920 --EEQRQALHSLE---------LHYQAFLRDSQDAG-----GFGPEDRLMAEREYGSCSH 963
Query: 3871 NYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQ 3930
+Y + Q + + R Q +++ + +L T T + +L P
Sbjct: 964 HYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRT---VHRLRLPL--------D 1012
Query: 3931 QEEHRQLRELIAEHKPHIDKMNKTGPQLLELS--PGEGFSIQEKYVAADTLYSQIKEDVK 3988
+E R+ + IAE + ++ G + LS + ++ E AA TL S+++ +
Sbjct: 1013 KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLG 1072
Query: 3989 KRAVALDEAISQSTQFHDKIDQIL----------ESLERIVERLRQPPSISAEVEKIKEQ 4038
K L++ S S + +K+ I E L E+L++ ++ A + +++
Sbjct: 1073 K----LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEAT 1128
Query: 4039 ISENKNVSVDMEKLQPLYETLKQR-------GEEMIARSGGTDKDISAKAVQDKLDQMVF 4091
+ K + E QP ++ L+ GE + R G ++D+ + ++++ Q++
Sbjct: 1129 KASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHG--ERDVEVERWRERVAQLLE 1186
Query: 4092 IWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLED-PGIDPSVVKQ 4150
W+ + + R+ +L + + L ++D + ++ P D V++
Sbjct: 1187 RWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVRE 1246
Query: 4151 QQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIV--KKSID---------ELN 4199
Q + + EEI+ E+++ + I A + + +V K ++ ++
Sbjct: 1247 QLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQ 1306
Query: 4200 SAWDSLNKAWKDRIDKLEEAMQAAVQY----QDGLQAVFDWVDIAGGKLAS----MSPIG 4251
S +S+ + + D E QY + L+ + + +A + A ++ +
Sbjct: 1307 SGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVE 1366
Query: 4252 TDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKK---VTEESDKHTVQDPLMEL 4308
LE +Q E Q K++A ++ E+++ Q E++ ++ V + K ++Q+ L +L
Sbjct: 1367 AALEKQRQLAEAHAQAKAQAEREAKELQQ-RMQEEVVRREEAAVDAQQQKRSIQEELQQL 1425
Query: 4309 KLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIE 4368
+ S E I + + E A + + + + + L TE + GG ++
Sbjct: 1426 R---QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATE------RQRGGAEGELQ 1476
Query: 4369 IELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEE---ASNLQNKLEVLNQRWQNVL 4425
A+ + Q E + + D + E AS ++ + E ++ Q L
Sbjct: 1477 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREK-QRAL 1535
Query: 4426 EKTEQRKQQLDGALRQAKGFHGEIE---DLQQWLTDTERHL---LASKPLGGLPETAKEQ 4479
+ E+ + Q + A R+ + E+E +Q L +R L SK +TA+ +
Sbjct: 1536 QALEELRLQAEEAERRLR--QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE 1593
Query: 4480 LNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNE 4539
++ E A + +EE + Q+ + AR E E +L
Sbjct: 1594 RSLQEEHVAVAQLREEAERRAQQQAEAERAR--------------------EEAERELER 1633
Query: 4540 RKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEV 4599
+ K EAL L ++ Q +AE+ A R + Q + A +
Sbjct: 1634 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1693
Query: 4600 NSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKR 4659
+ Q+ E GT + + +Q+++ ++ + + + + + L R A ++
Sbjct: 1694 LEKQRQLAE----GTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK 1749
Query: 4660 AKQFHEAWSKL---MEWLEESEKSLDSELEIANDPDK--IKTQLAQHKEFQKSLGAKHSV 4714
++ +K+ ME L S+ + E ++ K ++ + + +E + ++
Sbjct: 1750 RQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRAL 1809
Query: 4715 YDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFT 4774
+ R R L E+ + A + + +L+E G++ + + E AL
Sbjct: 1810 AEEAKRQ-RQLAEEDA-ARQRAEAERVLAEKL----AAIGEATRLKTEAEIALKEKEAEN 1863
Query: 4775 DALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARE 4834
+ L+ L + + + E+Q D+ L KA EL ++ V+ R R+
Sbjct: 1864 ERLRRLAE-DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQ 1922
Query: 4835 L------IEGSRDDSSWVKVQMQ-ELS-TRWETVCALSISKQTRLEAALRQ---AEE--- 4880
+ ++ S + ++ K +++ EL R L +Q LEAA ++ AEE
Sbjct: 1923 VEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERR 1982
Query: 4881 FHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRA-ELNKATTM 4939
+ + LA E+ R ++ + L+ +++ + ++ E++ A +L A
Sbjct: 1983 RREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA 2042
Query: 4940 GDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQ----QRLASALAGLIAKQELLE 4995
L K ++ + +E+ +Q Q Q A A A +E E
Sbjct: 2043 AQKRLQ-------AEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2095
Query: 4996 A-LLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRR 5054
A + A + A++ ++ E + Q EE A+ Q E++ RK+ + + +R
Sbjct: 2096 ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL-RKEAEQEAA----RRA 2150
Query: 5055 AADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGS--------QTQIETKNPRVNLLVSKW 5106
A+ ++L+ D K+F +L + Q+E + + NLL +
Sbjct: 2151 QAEQAALRQK-QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEEL 2209
Query: 5107 QQVWLLALERRRKLNDALDRLEELR 5131
Q++ A E R+ + + L +R
Sbjct: 2210 QRLKAEATEAARQRSQVEEELFSVR 2234
Score = 69.3 bits (168), Expect = 1e-10
Identities = 208/1057 (19%), Positives = 422/1057 (39%), Gaps = 142/1057 (13%)
Query: 4258 KQQIEELKQFKSEAYQQQIEME-------RLNHQAELLLKKVTEESDKHTVQDPLMELKL 4310
K+ E Q +E + Q E+E RL+ +AE +L T++ EL+L
Sbjct: 1013 KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRS---ELEL 1069
Query: 4311 IWDSLEE-RIINRQH--KLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAI 4367
LE+ R ++ + KL+ L + Q A + L A E L E + V +
Sbjct: 1070 TLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAH----EEQLKEAQAVPATLPEL 1125
Query: 4368 EIELAKHHVLQNDVLAHQSTVEAVN------KAGNDLIESSAGE---EASNLQNKLEVLN 4418
E A L+ A Q T +A+ + + ++ GE E + ++ L
Sbjct: 1126 EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLL 1185
Query: 4419 QRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTER--HLLASKPLGGLPETA 4476
+RWQ VL +T+ R+++L+ RQ + + + L WL D R + + PL +
Sbjct: 1186 ERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLAD-SQAV 1244
Query: 4477 KEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETK 4536
+EQL +E+ +++ + + C + A+ Q IN +K+ E +
Sbjct: 1245 REQLR-----------QEQALLEEIERHGEKVEECQRFAK----QYINAIKD----YELQ 1285
Query: 4537 LNERKTKLEEALNLAME------FHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQID 4590
L K +LE + A + + +Q++++ T + + S+ + L +++
Sbjct: 1286 LVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRME 1345
Query: 4591 EHKVFAN-----------EVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRW 4639
E + A EV + E+ +L + K ++++ L + + V R
Sbjct: 1346 EEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRRE 1405
Query: 4640 EKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLA 4699
E V ++ RS+ + ++ +Q EA ++ ++E + S L I + ++ QL
Sbjct: 1406 EAAVDAQQQK-RSIQEELQQLRQSSEA--EIQAKARQAEAAERSRLRIEEEIRVVRLQL- 1461
Query: 4700 QHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVER 4759
+ E Q+ GA+ + R + +K ++ + + +++D+ VE
Sbjct: 1462 EATERQRG-GAEGELQALRARAEEAEAQKRQAQEE---AERLRRQVQDESQRKRQAEVEL 1517
Query: 4760 QNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDID----LVMNLIDNHKAFQ 4815
++++ + + ALQAL + R++ + AE + +++ + + L ++ +
Sbjct: 1518 ASRVKAEAEAAREKQRALQALEE--LRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1575
Query: 4816 KELGKRTSS----VQALKRSARE---LIEGSRDDSSWVKVQMQELS----------TRWE 4858
EL + +S L+RS +E + R+++ Q E RW+
Sbjct: 1576 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ 1635
Query: 4859 TVCALSISKQTRLEAALRQAEEFHSVVHALLE-WLAEAEQTLRFHGVLPDDEDALRTLID 4917
L ++ RL + + S+ A E EAE+ R G + R L +
Sbjct: 1636 ----LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAE 1691
Query: 4918 QHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQ 4977
Q E ++L E A+ A + + + + + AR + A A Q +
Sbjct: 1692 QELEKQRQLAEGTAQQRLAAEQ-ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKR 1750
Query: 4978 QRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEM 5037
Q L + LA + A+ E+L A A + + ++K K+ + E + L EE
Sbjct: 1751 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL-------AEEA 1803
Query: 5038 TRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETKNP 5097
R + ++ K ++ A + ++ Q RA +R A L G T+++T+
Sbjct: 1804 ARLRALAEE-AKRQRQLAEEDAARQ---------RAEAERVLAEKLAAIGEATRLKTEAE 1853
Query: 5098 RVNLLVSKWQQVWLLALERRRKLNDALDRLEELREFANFDFDIWRKKYMRWMNHKKSRVM 5157
+AL+ + N+ L RL E F R++ K+ +
Sbjct: 1854 --------------IALKEKEAENERLRRLAEDEAFQ-------RRRLEEQAAQHKADIE 1892
Query: 5158 DFFRRIDKDQDGKITRQE-FIDGILSSKFPTSRLEMSAVADIFDRDGDGYIDYYEFVAAL 5216
+ ++ K D ++ RQ+ ++ L + E+ A+ F++ G + + +
Sbjct: 1893 ERLAQLRKASDSELERQKGLVEDTLRQRRQVEE-EILALKASFEKAAAGKAELELELGRI 1951
Query: 5217 HPNKDAYKPITDADKIEDEVTRQVAKCKCAKRFQVEQ 5253
N + + ++E RQ+A + +R + E+
Sbjct: 1952 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEE 1988
Score = 40.0 bits (92), Expect = 0.064
Identities = 84/510 (16%), Positives = 207/510 (40%), Gaps = 52/510 (10%)
Query: 1078 EKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQI-RTPLER 1136
+ E+ K++ ++ L+ + EQE + L + E + + L+ RL + +R
Sbjct: 2164 DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR 2223
Query: 1137 DDLHESVFRITEQ----EKLKKELER----------------LKDDLGTITNKCEEFFSQ 1176
+ E +F + Q KLK +E L+++ + EE
Sbjct: 2224 SQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARL 2283
Query: 1177 AAASSSVPTLRSELNVVLQNMNQVYSMSSTYI-DKLKTVNLVLKNTQAAEALVKLYETKL 1235
+ A+ LR + +++ Q +++ + +K++ V + AE L + E
Sbjct: 2284 SVAAQEAARLRQ---LAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ 2340
Query: 1236 CEEEAVIADKNNI-ENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERD 1294
+ + DK + + L + ++ ++ +RQ + E ++ K EM + +
Sbjct: 2341 EQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAE 2400
Query: 1295 LDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQR 1354
D +++A+++ E+ + ++ ++ + + L + I ++E +
Sbjct: 2401 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKE 2460
Query: 1355 KIQ-ENQPENSKTLATQLNQQKMLVSEIE-MKQSKMDEC------QKYAEQYSATVKD-Y 1405
K+Q E + K+ Q QQ+ L+ E + ++QS + E +++ EQ A ++ +
Sbjct: 2461 KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLF 2520
Query: 1406 ELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRY--------------TALV 1451
+ + + + + QQ+ ++++M+ ++ + R R L
Sbjct: 2521 QDEVAKAQQLREEQQR---QQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE 2577
Query: 1452 TLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPF 1511
Q + + +RL E+ + LEE+ + + ++E+ +KTL + A P
Sbjct: 2578 QQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPA 2637
Query: 1512 SKQKISSEEISTKKEQLSEALQTIQLFLAK 1541
++ + +++ ++ LQ + A+
Sbjct: 2638 AEAEPEHSFDGLRRKVSAQRLQEAGILSAE 2667
Score = 35.0 bits (79), Expect = 2.1
Identities = 73/348 (20%), Positives = 135/348 (38%), Gaps = 54/348 (15%)
Query: 4633 ISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLM-------EWLEESEKSLDSEL 4685
+ V+ W K+ ++ER + L +R + +KL E L +++ L S++
Sbjct: 364 LDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDV 423
Query: 4686 -------------EIANDPDKIKTQLAQ-HKEFQKSLGAKHSVYDTTNRTGRSLKEKTSL 4731
E+ D DK + + + Q +H + R L E+
Sbjct: 424 RLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVA 483
Query: 4732 --ADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEP 4789
+ NL+L ++ + + +SV+R+ +LE++ L LQ L+ W+ E
Sbjct: 484 IRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTL------RYLQDLLAWVE--EN 535
Query: 4790 QLAEDQPVHG-DIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSR----DDSS 4844
Q D G D+ V + +H+ + + + + ++ + +L +R D
Sbjct: 536 QHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLG 595
Query: 4845 WVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHAL---LEWLAEAEQTLRF 4901
+ +Q +L L+ SK A LR E HS V A L WL E E+
Sbjct: 596 RLDLQYAKL---------LNSSK-----ARLRSLESLHSFVAAATKELMWLNEKEEE-EV 640
Query: 4902 HGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHP 4949
D + + + M++LE K ++ + GD +L HP
Sbjct: 641 GFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHP 688
Score = 35.0 bits (79), Expect = 2.1
Identities = 22/51 (43%), Positives = 26/51 (50%)
Query: 5433 EDSGLITTAAARVRTQFADSKKTPSRPGSRAGSKAGSRASSRRGSDASDFD 5483
E +GL AA T+ S + S GS AGS+ GSR SR GS FD
Sbjct: 4457 EGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTGSRTGSRAGSRRGSFD 4507
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 861 bits (2224), Expect = 0.0
Identities = 637/2272 (28%), Positives = 1151/2272 (50%), Gaps = 200/2272 (8%)
Query: 641 EEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKI 700
E+ ++++QDLL WV+E Q ++D EWG DLPSVE+ L +H+ +H++IEEF + ++ A+
Sbjct: 522 EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS 581
Query: 701 SEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE 760
E Q++ + Y + L RL+ QYAKLLN+S+ + R L++LH+FV+ AT EL+WLNEKEE
Sbjct: 582 DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE 641
Query: 761 EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR 820
EEV +DWS+RNTN+ KK+ ++ LMREL+ KE+ IK +Q ++LL E+HPAR T+E+++
Sbjct: 642 EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 701
Query: 821 AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSI 880
AA+QTQWSW+LQLC C+E H+KEN AYF+FF+D +EA L+ L++A++RKYSCDRS+++
Sbjct: 702 AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATV 761
Query: 881 HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ 940
+LEDL+Q++ +EKE+L +YK ++ L +AK ++QLKPR+ P++ +P+ A+CDY+Q
Sbjct: 762 TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 821
Query: 941 IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ 1000
+E+T++K DEC L + + WKV+S +G+EA VPSVCF VPPPN+EA + R+E Q+Q
Sbjct: 822 VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ 881
Query: 1001 NVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFL 1060
++TLWH+ H++MKS+++W L ++ IR+ ++A+ +T+ P E +Q L +L+ ++ FL
Sbjct: 882 ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 941
Query: 1061 EDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLE 1120
DSQ++ F D E+E C +YQ+LL+S E+ QEES ISE+++IRL+LE
Sbjct: 942 RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE 1001
Query: 1121 NCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAAS 1180
CE R + ++R PL+++ E RI EQ+K + E+E L + ++ + E+ + S
Sbjct: 1002 ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1061
Query: 1181 SSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEA 1240
+ PTLRSEL + L + QV S+S+ Y++KLKT++LV++ TQ AE +++ +E +L E +A
Sbjct: 1062 PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1121
Query: 1241 VIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWH 1300
V A +E ++LK+ R++ + ++ F AL DEL+ A+ + + + + + ERD++ +
Sbjct: 1122 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1181
Query: 1301 KEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQ 1360
+E+ QL+ERWQ V Q D R R+LE +G+ L+YYR++ PL W+Q Q +IQ
Sbjct: 1182 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1241
Query: 1361 PENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQ 1420
+S+ + QL Q++ L+ EIE K++ECQ++A+QY +KDYELQ +TY+A ++
Sbjct: 1242 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLE-PV 1300
Query: 1421 KSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKK 1480
SP K+ ++QS ++ +IQE++DLRT Y+ L TL +QYIKF ++L+R+EEEE+ E+++
Sbjct: 1301 ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRA 1360
Query: 1481 E------HVEKAKELQKWVSNISKTLK-DAEKAGKPPFSKQKISSEEISTKKEQLSEALQ 1533
E VE A E Q+ ++ K AE+ K Q+ EE+ ++E +A Q
Sbjct: 1361 EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAK---ELQQRMQEEVVRREEAAVDAQQ 1417
Query: 1534 TIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKI-V 1592
++ ++++++ L++S +Q + ++ S +++EE+I V
Sbjct: 1418 ----------------QKRSIQEELQQLRQSSEAEIQAKARQAEAAERS-RLRIEEEIRV 1460
Query: 1593 AERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQ--EELQKDMQGS 1650
Q E E+ +G + G +A E +K Q+++ E L++ +Q
Sbjct: 1461 VRLQLEATERQRGGAE----------GELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1510
Query: 1651 AQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVT 1710
+Q + + +K E ++ +AL Q L E +++ E+ + Q++ E + V
Sbjct: 1511 SQRKRQAEVELASRVKAEAEAAREKQRAL--QALEELRLQAEEAERRLRQAEVERARQVQ 1568
Query: 1711 TAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDG 1770
A+ ET + +A +L+ + L ++ A + ++ E+ Q+ +
Sbjct: 1569 VAL--ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ--QQAEA 1624
Query: 1771 KSAIGE-EDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQ 1829
+ A E E E+ L+ + ++ E + QQ +A+ EK + A+
Sbjct: 1625 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK----------QKEEAE 1674
Query: 1830 VLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEF 1889
++G+ EE+ Q+ + E ++ + LAE + +L + ++EL + A+ +
Sbjct: 1675 REARRRGK---AEEQAVRQRELAEQELEKQRQLAEGTAQQRL--AAEQELIRLRAETEQG 1729
Query: 1890 EHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAK 1949
E Q E+EL L+ A ++++ ++ + ++ + S R E ++
Sbjct: 1730 EQQRQLLEEELARLQREA------AAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1783
Query: 1950 SCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCG 2009
S S++ +++ A R+L R R+L + ++ D + +A
Sbjct: 1784 STSEKSKQRLEAEAGR---FRELAEEAARLRALAEEAKRQRQLAEE--DAARQRAEAERV 1838
Query: 2010 LLAGLQAC-EATASKHLSEPIAVDPKNLQ----RQLEETKALQGQISSQQVAVEKLKKTA 2064
L L A EAT K +E IA+ K + R+L E +A Q + +Q A K
Sbjct: 1839 LAEKLAAIGEATRLKTEAE-IALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHK----- 1892
Query: 2065 EVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEML 2124
D L + L+ G ED + + E++ L+++ ++
Sbjct: 1893 ---ADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEI-------LALKASFEKAA 1942
Query: 2125 DWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDP 2184
G E L E G++ N+ +D + E + A RQ + A E+ ++ E
Sbjct: 1943 --AGKAELEL-ELGRIRSNA---EDTLRSKEQAELE-AARQRQLAAEEERRRREAE---- 1991
Query: 2185 STASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALT 2244
+ K L+A EA+ + K L ++E LK KVE L E+ + + Q
Sbjct: 1992 ------ERVQKSLAAE-EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ 2044
Query: 2245 EVDVPGKDVTE------LSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLE 2298
E E + Q QE + + L+ L + +++A V +
Sbjct: 2045 EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARV-Q 2103
Query: 2299 KTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGA 2358
++ +++E+ + K+ A Q + A K K +E ++ Q +
Sbjct: 2104 AEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQ 2163
Query: 2359 EDLGKS-LEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLN 2417
+ + +E KK E+ + ++++ ++ L T K + + L
Sbjct: 2164 KQAADAEMEKHKKFAEQTLRQKAQVEQ----ELTTLRLQLEETDHQKNL--LDEELQRLK 2217
Query: 2418 GEGTATNTEEFWANKGLTSIKKDMTDISH-----GYEDLGLLLKDKIAELNTKLSKLQKA 2472
E T + + L S++ M ++S E+ L+L+DK NT+ +
Sbjct: 2218 AEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKD---NTQ----RFL 2270
Query: 2473 QEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQE---L 2529
QEE+ M Q ++ + + Q+ A A + +Q E LK+ + VQE L
Sbjct: 2271 QEEAEKMKQVAEEAARLSVAAQEA-ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2329
Query: 2530 KDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQ-TVE 2588
K + ELL++ + + ++ +L D++Q ++ + FQ T+E
Sbjct: 2330 KAE-AELLQQQKELAQ---------------EQARRLQEDKEQMAQQLAEETQGFQRTLE 2373
Query: 2589 AQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILS 2648
A+ ++ L ++ + +++++ + E + + + E+ +
Sbjct: 2374 AERQRQL------------------EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE 2415
Query: 2649 RPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSD 2708
GE + ++ + Q + Q + + +AI + + + L+
Sbjct: 2416 EIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ------- 2468
Query: 2709 LDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCED----LSALVKEE 2764
+ KL + Q L+ Q ++Q EK + + E L L ++E
Sbjct: 2469 -EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDE 2527
Query: 2765 YLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQN 2824
KA+ R+ + + + +EQ+ + V ++ A H+ ++ R Q L ++++
Sbjct: 2528 VAKAQQLREEQ--QRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRR 2585
Query: 2825 KSHPISA--------KLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLL 2868
+ + A +L +LE + S+ +TA KT+ G + L
Sbjct: 2586 QQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDAL 2637
Score = 565 bits (1455), Expect = e-160
Identities = 274/465 (58%), Positives = 366/465 (78%), Gaps = 5/465 (1%)
Query: 60 DPAERAVLR----IADERDKVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEV 115
+PA R L DERD+VQKKTFTKW+N+HL+K ++H++DLYEDLRDGHNLISLLEV
Sbjct: 27 EPARRGYLYQQLCCVDERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEV 86
Query: 116 LSGDTLPREKGRMRFHRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIIL 175
LSGD+LPREKGRMRFH+LQNVQIALDYL+ RQVKLVNIRNDDI DGNPKLTLGLIWTIIL
Sbjct: 87 LSGDSLPREKGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIIL 146
Query: 176 HFQISDIHVTGESEDMSAKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRP 235
HFQISDI V+G+SEDM+AKE+LLLW+Q+ EGY G+RC+NFT+ WRDG+LFNAIIH+++P
Sbjct: 147 HFQISDIQVSGQSEDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKP 206
Query: 236 DLIDMNTVAVQSNLANLEHAFYVAEK-IGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAF 294
LIDMN V Q+NL NL+ AF VAE+ +GV RLLDPEDVDV PDEKS+ITYVSSLYDA
Sbjct: 207 LLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAM 266
Query: 295 PKVPEGGEGIGANDVEVKWIEYQNMVNYLIQWIRHHVTTMSERTFPNNPVELKALYNQYL 354
P+VP+ +G+ AN+++++W EY+ +V L+QW+RHH ER FP++ E++ L++Q+L
Sbjct: 267 PRVPDVQDGVRANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFL 326
Query: 355 QFKETEIPPKETEKSKIKRLYKLLEIWIEFGRIKLLQGYHPNDIEKEWGKLIIAMLEREK 414
+FKE E+P KE +K++ K +Y+ LE ++ G++K+ GYHP D+EKEWGKL +A+LEREK
Sbjct: 327 KFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREK 386
Query: 415 ALRPEVERLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYI 474
LR E ERLE LQ+I ++Q ++ +CE++L A LQSD + L +G Q E+ +
Sbjct: 387 QLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDL 446
Query: 475 LECENLLRQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNE 519
+ ++++R DVQ L DG++ Q +Q+ +RV +L + ++A+R E
Sbjct: 447 DKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTE 491
Score = 111 bits (277), Expect = 2e-23
Identities = 355/1874 (18%), Positives = 725/1874 (38%), Gaps = 306/1874 (16%)
Query: 2676 GQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQK 2735
G S + Q++ + Q +S + +L D+ +L + + H + E A++
Sbjct: 963 GSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARE 1022
Query: 2736 MKQEI-QQEKKQIKVA---------QALCEDLSALVKEEYLKAELSRQLEGILKSFKDVE 2785
Q I +Q+K Q +V A E + AL + L +LE L + V
Sbjct: 1023 CAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVR 1082
Query: 2786 QKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKD 2845
+ +++ L++ Q +A + KE Q + A L LE+ K
Sbjct: 1083 SLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQ----AVPATLPELEAT----KA 1134
Query: 2846 FSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQ----------------LNTIKTN 2889
K L AQ+ + T + L + +G+++ +LQ + +
Sbjct: 1135 SLKKLRAQAEAQQPTF---DALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLER 1191
Query: 2890 WDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFC--LDPAEGENS 2947
W Q R+ +L++ + Y+E + L W+ + E+I+ D
Sbjct: 1192 WQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQ 1251
Query: 2948 IAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSK 3007
+ + ++L +E+++H VE A ++ K
Sbjct: 1252 LRQEQALLEEIERHGEKVEECQRFAKQYINAI---------------------------K 1284
Query: 3008 KFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQA 3067
+ L+ +T K + S K ++Q E + I + + + + ++ T+ K +
Sbjct: 1285 DYELQLVTYKAQLEPVASPAKKPKVQSGSESV-IQEYVDLRTHYSELTTLTSQYIKFISE 1343
Query: 3068 LKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVET-IAQEHSTLSQQVDEKCSFLETKLQG 3126
+++ +RLA+ E + + L+ + +A+ H+ Q + + L+ ++Q
Sbjct: 1344 TLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ- 1402
Query: 3127 IGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKET-IKAFLKKLEALMASNDNA 3185
E+ + D + + + L++ E I+A ++ EA S
Sbjct: 1403 --------EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRI 1454
Query: 3186 NKTCKMM-LATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKL 3244
+ +++ L E T G + +L+AL +AR E+ E ++ +E +L
Sbjct: 1455 EEEIRVVRLQLEATERQRGGAEGELQAL-----------RARAEEAEAQKRQAQEEAERL 1503
Query: 3245 KEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLI 3304
+ + +ESQ E E ++ K E E + KQ+ + L + +
Sbjct: 1504 RR--------QVQDESQRKRQAEVELASRV--------KAEAEAAREKQRALQALEELRL 1547
Query: 3305 QSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVD 3364
Q+ + L + +RA Q+Q AL
Sbjct: 1548 QAEEAE-----------------RRLRQAEVERARQVQVAL------------------- 1571
Query: 3365 TEELVANQKPPSAEFKVVKAQIQEQKL-LQRLLDDRKSTVEVIKREGEKIATTAEPADKV 3423
Q+ AE + +A E+ L+R L + V ++ E E+ A A++
Sbjct: 1572 ----ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERA 1627
Query: 3424 KILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEP 3483
+ + L RW+ N+A Q E VAQQ + L + EK+ E
Sbjct: 1628 REEAEREL--ERWQLKANEALRLRLQAEE---VAQQ-----KSLAQ--AEAEKQKEEAER 1675
Query: 3484 IGTQASKLEEQIAQHKALEDDIINHNKHLHQAVS---IGQSLKVLSSREDKDMVQSKLDF 3540
+ K EEQ + + L + + + L + + + +++ R + + + +
Sbjct: 1676 EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL 1735
Query: 3541 SQVWYIEIQEKSHSRSELLQQALCN-AKIFGEDEVELMNWLN--EVHDKLSKLSVQDYST 3597
+ +Q ++ + ++ Q+ AK+ E EV L + E S+ S Q
Sbjct: 1736 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1795
Query: 3598 EG-----LWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKA 3652
E L ++ + LR L E+ ++Q ++ + +Q E ++ +KL AI
Sbjct: 1796 EAGRFRELAEEAARLRALAEEAKRQRQLAEE------DAARQRAEAE-RVLAEKLAAIG- 1847
Query: 3653 RYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQA 3712
+ T+L T+ L++ RL E+ ++E + ++ + E A
Sbjct: 1848 ---EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI----EERLA 1900
Query: 3713 QMRPKELKKEAKNNKALL-DSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTIT 3771
Q+R K E + K L+ D+L + E++ +A EK A E
Sbjct: 1901 QLR-KASDSELERQKGLVEDTLRQRRQVEEEILALKA--SFEKAAAGKAEL--------- 1948
Query: 3772 QKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTME 3831
E++ +RS D E + + ++ ++ + E+ + A+ +VQK+ E
Sbjct: 1949 ----ELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEE---ERRRREAEERVQKSLAAE 2001
Query: 3832 ---ILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLE- 3887
+ K ++++ + K+ EE + ++++ ++ + Q +++ LQ E
Sbjct: 2002 EEAARQRKAALEEVERLKAKV------EEARRLRERAEQESARQLQLAQEAAQKRLQAEE 2055
Query: 3888 RAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPH 3947
+A + Q E +EL L + QS++ QL A E R+ EE + R
Sbjct: 2056 KAHAFAVQQKE--QELQQTLQQEQSVLDQLRGEA---EAARRAAEEAEEARVQAEREAAQ 2110
Query: 3948 IDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQST----- 4002
+ + +L + + + + + AA+ L + +++ +RA A A+ Q
Sbjct: 2111 SRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAE 2170
Query: 4003 -QFHDK-----------IDQILESLE-RIVERLRQPPSISAEVEKIKEQISENK------ 4043
+ H K ++Q L +L ++ E Q + E++++K + +E
Sbjct: 2171 MEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQV 2230
Query: 4044 -----NVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHT 4098
+V V ME+L L ++ +I R DKD + + +Q++ ++M + E
Sbjct: 2231 EEELFSVRVQMEELSKLKARIEAENRALILR----DKDNTQRFLQEEAEKMKQVAEEAAR 2286
Query: 4099 L-VEEREAKLLDVMELAEKFWCDHMSLIVT-IKDTQDFIRDLEDPGIDPSVVKQQQEAAE 4156
L V +EA L +LAE+ +L +K+ +++ + +++QQ+E A+
Sbjct: 2287 LSVAAQEAARL--RQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ 2344
Query: 4157 TIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKL 4216
E+ LQE+ + ++ E + + E + +A + ++ ++
Sbjct: 2345 ---EQARRLQEDKE-------QMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKL-RV 2393
Query: 4217 EEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQI 4276
E +A + ++ Q + G KL + T+ Q +E I
Sbjct: 2394 AEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE-------------I 2440
Query: 4277 EMERLNHQAELLLKKVTE-ESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQ 4335
+ ++ +H AE L + + E E +K +Q E KL+ EE +Q +L AL Q
Sbjct: 2441 QRQQSDHDAERLREAIAELEREKEKLQQ---EAKLLQLKSEEMQTVQQEQLLQETQALQQ 2497
Query: 4336 FQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEI----ELAKHHVLQNDVLAHQSTVEAV 4391
++L+ + LL ++ + + +E E+AK L+ + Q +E
Sbjct: 2498 ---------SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQE 2548
Query: 4392 NKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIED 4451
+ L+ S EEA Q++ E +R Q L++ EQ+++Q + L + + + +
Sbjct: 2549 RQR---LVASM--EEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEE---NQRLRE 2600
Query: 4452 LQQWLTDTERHLLA 4465
Q L + R LA
Sbjct: 2601 QLQLLEEQHRAALA 2614
Score = 94.0 bits (232), Expect = 4e-18
Identities = 353/1847 (19%), Positives = 705/1847 (38%), Gaps = 283/1847 (15%)
Query: 3201 DLVGIKRDLEALSKQCNKLLDRAQ--AREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHE 3258
D + +R+ + S +LL + A+EE R + S+LK+ + L+ E
Sbjct: 954 DRLMAEREYGSCSHHYQQLLQSLEQGAQEES------RCQRCISELKDIRLQLEACETRT 1007
Query: 3259 ESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAK--------- 3309
+ + ++ E + + I Q Q +V LG+G+ + +A+
Sbjct: 1008 VHRLRLPLDKEPARECA--------QRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPE 1059
Query: 3310 -STSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEEL 3368
S + L +L+ + + + A +L+ L Q A E L + +E
Sbjct: 1060 PSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEA 1119
Query: 3369 VA------NQKPPSAEFKVVKAQIQ-EQKLLQRLLDDRKSTVEVIKREGEKIATTAEPAD 3421
A + A K ++AQ + +Q L D+ + EV +R ++ +
Sbjct: 1120 QAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVE 1179
Query: 3422 KVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNC 3481
+ + ++++ L RW+A+L + + R R+LE + + + E+ +PL WL +R
Sbjct: 1180 RWR--ERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQI 1237
Query: 3482 EPIGTQASK-LEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDF 3540
+ + S+ + EQ+ Q +AL ++I H + + + + + +V K
Sbjct: 1238 QAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQL 1297
Query: 3541 SQVWYIEIQEKSHSRSELLQQALCNAKI-FGEDEVELMNWLNEVHDKLSKLSVQDYSTEG 3599
V + K S SE + Q + + + E ++ + + L ++ ++ E
Sbjct: 1298 EPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE- 1356
Query: 3600 LWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITK 3659
+Q++E R R V+ AL +L + Q K +A + + +
Sbjct: 1357 --QQRAEERE-------RLAEVEAALEKQRQLAEAHA-------QAKAQAEREAKELQQR 1400
Query: 3660 LSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKEL 3719
+ +V + E A+ ++ S EEL E E+ + K +A A+ +
Sbjct: 1401 MQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQA------KARQAEAAERSRLRI 1454
Query: 3720 KKEAKNNKALLDSL-NEVSSALLELVPWRAR----EGLEKMVAEDNERYRLVSDTITQKV 3774
++E + + L++ + A EL RAR E ++ E+ ER R +Q+
Sbjct: 1455 EEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRK 1514
Query: 3775 EEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILR 3834
+ + + AE E ++ L +L ++RL+ ++ +L+ E+ R
Sbjct: 1515 RQAEV------ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR-----QAEVER 1563
Query: 3835 HKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVN 3894
+ V+ + +E E QS + +E+ QLER+
Sbjct: 1564 ARQ-----VQVALETAQRSAEAELQSKRASF--------------AEKTAQLERS----- 1599
Query: 3895 QFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKT 3954
L E ++QL E E QQQ E + RE E + +++
Sbjct: 1600 ------------LQEEHVAVAQLRE---EAERRAQQQAEAERARE---EAERELERWQLK 1641
Query: 3955 GPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILES 4014
+ L L Q+K +A Q KE+ ++ A +A Q+ + + +Q LE
Sbjct: 1642 ANEALRLRLQAEEVAQQKSLAQAEAEKQ-KEEAEREARRRGKAEEQAVRQRELAEQELEK 1700
Query: 4015 LERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTD 4074
++ E Q ++AE E I+ + + E+ + L E R + A +
Sbjct: 1701 QRQLAEGTAQ-QRLAAEQELIRLRAETEQG-----EQQRQLLEEELARLQREAAAATQKR 1754
Query: 4075 KDISAKAVQDKLDQMVFIWENIHTLVEER----------EAKLLDVMELAEKFWCDHMSL 4124
+++ A+ + + + V + E R EA+ ELAE+ +
Sbjct: 1755 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE-----AAR 1809
Query: 4125 IVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQE------ELDIVI---NL 4175
+ + + R L + +Q+ EA + E++ + E E +I +
Sbjct: 1810 LRALAEEAKRQRQL----AEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEA 1865
Query: 4176 GSELIAACGEPDKPIVKKSIDE--------LNSAWDSLNKAWKDRIDK----LEEAMQAA 4223
+E + E D+ ++ ++E + L KA +++ +E+ ++
Sbjct: 1866 ENERLRRLAE-DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQR 1924
Query: 4224 VQYQDGLQAV-FDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQ---IEME 4279
Q ++ + A+ + A GK +G + + +Q + EA +Q+ E E
Sbjct: 1925 RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE 1984
Query: 4280 RLNHQAELLLKK--VTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQ 4337
R +AE ++K EE + L E++ + +EE R+ + + L Q
Sbjct: 1985 RRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ 2044
Query: 4338 HALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAH-QSTVEAVNKAGN 4396
A + L +QK E EL + + VL + EA +A
Sbjct: 2045 EAAQKRLQAEEKAHAFAVQQK---------EQELQQTLQQEQSVLDQLRGEAEAARRAAE 2095
Query: 4397 DLIES--SAGEEASNLQNKLEVLNQRWQNVLEKTEQ-----------RKQQLDGALRQAK 4443
+ E+ A EA+ + ++E + Q+ E+ + RK+ A R+A+
Sbjct: 2096 EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQ 2155
Query: 4444 GFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEET--YKSLM 4501
+ Q + E+H ++ +T +++ V E+ EET K+L+
Sbjct: 2156 AEQAALRQKQAADAEMEKHKKFAE------QTLRQKAQVEQELTTLRLQLEETDHQKNLL 2209
Query: 4502 QKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNE---RKTKLE-EALNLAMEFHNS 4557
+ Q L K+ T + + ++E+ SV ++ E K ++E E L + ++
Sbjct: 2210 DEELQRL----KAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDN 2265
Query: 4558 LQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLK 4617
Q F+ +AE+ VA + L + + A E + + + E K
Sbjct: 2266 TQRFLQ--EEAEKMKQVAEEAAR-LSVAAQEAARLRQLAEEDLAQQRALAE--------K 2314
Query: 4618 YFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSL-DDARKRAKQFHEAWSKLMEWLEE 4676
+K V L + ++ + E+ R L +D + A+Q E LE
Sbjct: 2315 MLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA 2374
Query: 4677 SEKSLDSELEIANDPDKIKTQLAQ--------HKEFQKSLGAKHSVYDTTNRTGRSLKEK 4728
+ +LE++ + +++K ++A+ ++ Q+ + + +RT + +EK
Sbjct: 2375 ERQ---RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEK 2431
Query: 4729 TSLAD-----------DNLKLDDMLSELRDKWDTICG-------KSVERQNKLEEALLFS 4770
+L D +L + ++EL + + + KS E Q +E LL
Sbjct: 2432 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLL-- 2489
Query: 4771 GQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKR 4830
Q T ALQ +L + L ++ + + + L + A ++L + Q
Sbjct: 2490 -QETQALQQ--SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2546
Query: 4831 SARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLE 4890
R+ + S +++ + + +E R + + +LE RQ EE
Sbjct: 2547 QERQRLVASMEEARRRQHEAEEGVRRKQ-------EELQQLEQQRRQQEEL--------- 2590
Query: 4891 WLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKAT 4937
LAE Q LR + L+ L +QH+ + EE A AT
Sbjct: 2591 -LAEENQRLR---------EQLQLLEEQHRAALAHSEEVTASQVAAT 2627
Score = 85.1 bits (209), Expect = 2e-15
Identities = 295/1541 (19%), Positives = 608/1541 (39%), Gaps = 226/1541 (14%)
Query: 3708 EASQAQMRPKELKKEAKNNKALLDSLN-------EVSSAL--------LELVPWRAREGL 3752
EA++A + K+L+ +A+ + D+L EV L +E+ WR R
Sbjct: 1130 EATKASL--KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRER--- 1184
Query: 3753 EKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIR 3812
VA+ ER++ V + E++ + + + ++AD +W+ + ++ + +
Sbjct: 1185 ---VAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1241
Query: 3813 LEQDQT-SAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQ--SMKKKLDKVL 3869
L Q QL+ ++ EI RH + +++ + + + A + E Q + K +L+ V
Sbjct: 1242 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA 1301
Query: 3870 KNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQ 3929
+ + QS + Y +L +E ++ SQ ETLR+
Sbjct: 1302 SP------------AKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIK--FISETLRR 1347
Query: 3930 QQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKK 3989
+EE R + AE + + ++ + +L+ + + A L +++E+V +
Sbjct: 1348 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1407
Query: 3990 RAVALDEAISQSTQFHDKIDQILESLERIVE-RLRQPPSISAEVEKIKEQISENKNVSVD 4048
R A +A Q +++ Q+ +S E ++ + RQ + +I+E+I
Sbjct: 1408 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR-------- 1459
Query: 4049 MEKLQPLYETLKQRG----EEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEERE 4104
+ +LQ L T +QRG E R+ + + + Q++ +++ + +E +
Sbjct: 1460 VVRLQ-LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLR------RQVQDESQ 1512
Query: 4105 AKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIRE-EID 4163
K +ELA + + + ++ Q ++ LE+ + Q +EA +R+ E++
Sbjct: 1513 RKRQAEVELASRVKAEAEAA----REKQRALQALEELRL------QAEEAERRLRQAEVE 1562
Query: 4164 GLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWD-SLNKAWKDRIDKLEEAMQA 4222
++ + + E E + + S E + + SL + EEA +
Sbjct: 1563 RARQ-----VQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERR 1617
Query: 4223 AVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLN 4282
A Q + +A + A +L + ++ Q EE+ Q KS A Q E E+
Sbjct: 1618 AQQQAEAERAREE----AERELERWQLKANEALRLRLQAEEVAQQKSLA---QAEAEKQK 1670
Query: 4283 HQAELLLKKVTEESDKHTVQDPLMELKLIWD-SLEERIINRQHKLEGALLALG------- 4334
+AE ++ + ++ Q L E +L L E ++ E L+ L
Sbjct: 1671 EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1730
Query: 4335 QFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKA 4394
Q + L+E LA L ++++ + +E ELAK +LA ++ E +++
Sbjct: 1731 QQRQLLEEELARLQREAAAATQKR------QELEAELAKVRAEMEVLLASKARAEEESRS 1784
Query: 4395 GNDL----IESSAG------EEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKG 4444
++ +E+ AG EEA+ L+ E ++ Q E +++ + + L +
Sbjct: 1785 TSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLA 1844
Query: 4445 FHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKG 4504
GE L+ TE + + E E+L + AF+ + ++ K
Sbjct: 1845 AIGEATRLK-----TEAEIALKEK-----EAENERLR-RLAEDEAFQRRRLEEQAAQHKA 1893
Query: 4505 --QQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFI 4562
++ LA+ K++++ +++ VE L +R+ EE L L F +
Sbjct: 1894 DIEERLAQLRKASDSELERQKG-------LVEDTLRQRRQVEEEILALKASFEKAAAG-- 1944
Query: 4563 NWLTQAEQTLNVASRPSLILDTV-------LFQIDEHKVFANEVNSHREQIIELDKTGTH 4615
+AE L + S DT+ L + ++ A E RE + K+
Sbjct: 1945 ----KAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAA 2000
Query: 4616 LKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLE 4675
+ ++++ L + V+RL + R+RA+Q E+ +L E
Sbjct: 2001 EEEAARQRKAAL-------------EEVERLKAKVEEARRLRERAEQ--ESARQLQLAQE 2045
Query: 4676 ESEKSLDSELEIANDPDKIKTQLAQHKE--FQKSLGAKHSVYDTTNRTGRSLKEKTSLAD 4733
++K L +E +K Q KE Q++L + SV D + + A+
Sbjct: 2046 AAQKRLQAE-------EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE 2098
Query: 4734 D-NLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLA 4792
+ ++ + ++ R + VE +L+++ Q QA + L + Q A
Sbjct: 2099 EARVQAEREAAQSR--------RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2150
Query: 4793 E-----DQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVK 4847
+Q ++ HK F ++ ++ + V+ + R +E + + +
Sbjct: 2151 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2210
Query: 4848 VQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPD 4907
++Q L + L + Q EE L+ EAE ++
Sbjct: 2211 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSK-----LKARIEAEN----RALILR 2261
Query: 4908 DEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFE 4967
D+D + + + E MK++ E+ A L+ A + + D + RA E
Sbjct: 2262 DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED--------LAQQRALAE 2313
Query: 4968 EVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALI 5027
++L K+ Q + A L A+ ELL+ Q L + +++ Q EE +
Sbjct: 2314 KML---KEKMQAVQEA-TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGF- 2368
Query: 5028 AEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSG 5087
Q +E ++Q ++ + K R A+ S Q+ + A R R A +
Sbjct: 2369 ---QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA----EEDAQRFRKQAEEIGEKL 2421
Query: 5088 SQTQIETKNPRVNLLVSKWQQVWLLALERRR------KLNDALDRLEELREFANFDFDIW 5141
+T++ T+ K V L ++R++ +L +A+ LE +E + +
Sbjct: 2422 HRTELATQ--------EKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL 2473
Query: 5142 RKKYMRWMNHKKSRVMDFFRRIDK----DQDGKITRQEFID 5178
+ K ++ +++ + + + ++D + R+ FI+
Sbjct: 2474 QLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE 2514
Score = 78.6 bits (192), Expect = 2e-13
Identities = 352/1885 (18%), Positives = 731/1885 (38%), Gaps = 251/1885 (13%)
Query: 3336 QRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRL 3395
QR +L+++ L L+ LL+W+ + + V + + V+AQ+ + L +
Sbjct: 516 QRRPELEDSTLRY------LQDLLAWVEENQHRVDGAEW-GVDLPSVEAQLGSHRGLHQS 568
Query: 3396 LDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGI-S 3454
+++ ++ +E + + +++ PA + L LD ++ LLN ++ R R LE + S
Sbjct: 569 IEEFRAKIERARSDEGQLS----PATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHS 624
Query: 3455 VVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQ 3514
VA E + WL E+ V + + + + + + AL ++ K + +
Sbjct: 625 FVAAATKELM-----WLNEKEEEEVGFD-WSDRNTNMTAKKESYSALMRELELKEKKIKE 678
Query: 3515 AVSIGQSL--KVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGED 3572
+ G L + +R + Q+ L W +LQ C
Sbjct: 679 LQNAGDRLLREDHPARPTVESFQAALQTQWSW-------------MLQLCCC-------- 717
Query: 3573 EVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQ-ALLNGLEL 3631
E H K + Q +S + + + +L+ LQE L RK + D+ A + LE
Sbjct: 718 --------IEAHLKENAAYFQFFS--DVREAEGQLQKLQE-ALRRKYSCDRSATVTRLED 766
Query: 3632 LKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDK 3691
L Q DE +++L K + +AK + +QL R H H
Sbjct: 767 LLQDAQDE----KEQLNEYKGHL-------SGLAKRAKAVVQLKPR-HPAHPMRGRLPLL 814
Query: 3692 VEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVS-SALLELVPWRARE 3750
+ E V KG+E + + K L S +E + ++ LVP +E
Sbjct: 815 AVCDYKQVEVTVHKGDECQLVG------PAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQE 868
Query: 3751 GLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGD 3810
E + + + LV T+ ++ ++L Q + SW T + L
Sbjct: 869 AQEAVTRLEAQHQALV--TLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKP--- 923
Query: 3811 IRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLK 3870
EQ Q L+ L ++ + D +G E++ +++
Sbjct: 924 --EEQRQALHSLE---------LHYQAFLRDSQDAG-----GFGPEDRLMAEREYGSCSH 967
Query: 3871 NYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQ 3930
+Y + Q + + R Q +++ + +L T T + +L P
Sbjct: 968 HYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRT---VHRLRLPL--------D 1016
Query: 3931 QEEHRQLRELIAEHKPHIDKMNKTGPQLLELS--PGEGFSIQEKYVAADTLYSQIKEDVK 3988
+E R+ + IAE + ++ G + LS + ++ E AA TL S+++ +
Sbjct: 1017 KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLG 1076
Query: 3989 KRAVALDEAISQSTQFHDKIDQIL----------ESLERIVERLRQPPSISAEVEKIKEQ 4038
K L++ S S + +K+ I E L E+L++ ++ A + +++
Sbjct: 1077 K----LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEAT 1132
Query: 4039 ISENKNVSVDMEKLQPLYETLKQR-------GEEMIARSGGTDKDISAKAVQDKLDQMVF 4091
+ K + E QP ++ L+ GE + R G ++D+ + ++++ Q++
Sbjct: 1133 KASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHG--ERDVEVERWRERVAQLLE 1190
Query: 4092 IWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLED-PGIDPSVVKQ 4150
W+ + + R+ +L + + L ++D + ++ P D V++
Sbjct: 1191 RWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVRE 1250
Query: 4151 QQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIV--KKSID---------ELN 4199
Q + + EEI+ E+++ + I A + + +V K ++ ++
Sbjct: 1251 QLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQ 1310
Query: 4200 SAWDSLNKAWKDRIDKLEEAMQAAVQY----QDGLQAVFDWVDIAGGKLAS----MSPIG 4251
S +S+ + + D E QY + L+ + + +A + A ++ +
Sbjct: 1311 SGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVE 1370
Query: 4252 TDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKK---VTEESDKHTVQDPLMEL 4308
LE +Q E Q K++A ++ E+++ Q E++ ++ V + K ++Q+ L +L
Sbjct: 1371 AALEKQRQLAEAHAQAKAQAEREAKELQQ-RMQEEVVRREEAAVDAQQQKRSIQEELQQL 1429
Query: 4309 KLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIE 4368
+ S E I + + E A + + + + + L TE + GG ++
Sbjct: 1430 R---QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATE------RQRGGAEGELQ 1480
Query: 4369 IELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEE---ASNLQNKLEVLNQRWQNVL 4425
A+ + Q E + + D + E AS ++ + E ++ Q L
Sbjct: 1481 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREK-QRAL 1539
Query: 4426 EKTEQRKQQLDGALRQAKGFHGEIE---DLQQWLTDTERHL---LASKPLGGLPETAKEQ 4479
+ E+ + Q + A R+ + E+E +Q L +R L SK +TA+ +
Sbjct: 1540 QALEELRLQAEEAERRLR--QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE 1597
Query: 4480 LNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNE 4539
++ E A + +EE + Q+ + AR E E +L
Sbjct: 1598 RSLQEEHVAVAQLREEAERRAQQQAEAERAR--------------------EEAERELER 1637
Query: 4540 RKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEV 4599
+ K EAL L ++ Q +AE+ A R + Q + A +
Sbjct: 1638 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1697
Query: 4600 NSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKR 4659
+ Q+ E GT + + +Q+++ ++ + + + + + L R A ++
Sbjct: 1698 LEKQRQLAE----GTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK 1753
Query: 4660 AKQFHEAWSKL---MEWLEESEKSLDSELEIANDPDK--IKTQLAQHKEFQKSLGAKHSV 4714
++ +K+ ME L S+ + E ++ K ++ + + +E + ++
Sbjct: 1754 RQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRAL 1813
Query: 4715 YDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFT 4774
+ R R L E+ + A + + +L+E G++ + + E AL
Sbjct: 1814 AEEAKRQ-RQLAEEDA-ARQRAEAERVLAEKL----AAIGEATRLKTEAEIALKEKEAEN 1867
Query: 4775 DALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARE 4834
+ L+ L + + + E+Q D+ L KA EL ++ V+ R R+
Sbjct: 1868 ERLRRLAE-DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQ 1926
Query: 4835 L------IEGSRDDSSWVKVQMQ-ELS-TRWETVCALSISKQTRLEAALRQ---AEE--- 4880
+ ++ S + ++ K +++ EL R L +Q LEAA ++ AEE
Sbjct: 1927 VEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERR 1986
Query: 4881 FHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRA-ELNKATTM 4939
+ + LA E+ R ++ + L+ +++ + ++ E++ A +L A
Sbjct: 1987 RREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA 2046
Query: 4940 GDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQ----QRLASALAGLIAKQELLE 4995
L K ++ + +E+ +Q Q Q A A A +E E
Sbjct: 2047 AQKRLQ-------AEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2099
Query: 4996 A-LLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRR 5054
A + A + A++ ++ E + Q EE A+ Q E++ RK+ + + +R
Sbjct: 2100 ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL-RKEAEQEAA----RRA 2154
Query: 5055 AADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGS--------QTQIETKNPRVNLLVSKW 5106
A+ ++L+ D K+F +L + Q+E + + NLL +
Sbjct: 2155 QAEQAALRQK-QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEEL 2213
Query: 5107 QQVWLLALERRRKLNDALDRLEELR 5131
Q++ A E R+ + + L +R
Sbjct: 2214 QRLKAEATEAARQRSQVEEELFSVR 2238
Score = 69.3 bits (168), Expect = 1e-10
Identities = 208/1057 (19%), Positives = 422/1057 (39%), Gaps = 142/1057 (13%)
Query: 4258 KQQIEELKQFKSEAYQQQIEME-------RLNHQAELLLKKVTEESDKHTVQDPLMELKL 4310
K+ E Q +E + Q E+E RL+ +AE +L T++ EL+L
Sbjct: 1017 KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRS---ELEL 1073
Query: 4311 IWDSLEE-RIINRQH--KLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAI 4367
LE+ R ++ + KL+ L + Q A + L A E L E + V +
Sbjct: 1074 TLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAH----EEQLKEAQAVPATLPEL 1129
Query: 4368 EIELAKHHVLQNDVLAHQSTVEAVN------KAGNDLIESSAGE---EASNLQNKLEVLN 4418
E A L+ A Q T +A+ + + ++ GE E + ++ L
Sbjct: 1130 EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLL 1189
Query: 4419 QRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTER--HLLASKPLGGLPETA 4476
+RWQ VL +T+ R+++L+ RQ + + + L WL D R + + PL +
Sbjct: 1190 ERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLAD-SQAV 1248
Query: 4477 KEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETK 4536
+EQL +E+ +++ + + C + A+ Q IN +K+ E +
Sbjct: 1249 REQLR-----------QEQALLEEIERHGEKVEECQRFAK----QYINAIKD----YELQ 1289
Query: 4537 LNERKTKLEEALNLAME------FHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQID 4590
L K +LE + A + + +Q++++ T + + S+ + L +++
Sbjct: 1290 LVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRME 1349
Query: 4591 EHKVFAN-----------EVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRW 4639
E + A EV + E+ +L + K ++++ L + + V R
Sbjct: 1350 EEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRRE 1409
Query: 4640 EKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLA 4699
E V ++ RS+ + ++ +Q EA ++ ++E + S L I + ++ QL
Sbjct: 1410 EAAVDAQQQK-RSIQEELQQLRQSSEA--EIQAKARQAEAAERSRLRIEEEIRVVRLQL- 1465
Query: 4700 QHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVER 4759
+ E Q+ GA+ + R + +K ++ + + +++D+ VE
Sbjct: 1466 EATERQRG-GAEGELQALRARAEEAEAQKRQAQEE---AERLRRQVQDESQRKRQAEVEL 1521
Query: 4760 QNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDID----LVMNLIDNHKAFQ 4815
++++ + + ALQAL + R++ + AE + +++ + + L ++ +
Sbjct: 1522 ASRVKAEAEAAREKQRALQALEE--LRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1579
Query: 4816 KELGKRTSS----VQALKRSARE---LIEGSRDDSSWVKVQMQELS----------TRWE 4858
EL + +S L+RS +E + R+++ Q E RW+
Sbjct: 1580 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ 1639
Query: 4859 TVCALSISKQTRLEAALRQAEEFHSVVHALLE-WLAEAEQTLRFHGVLPDDEDALRTLID 4917
L ++ RL + + S+ A E EAE+ R G + R L +
Sbjct: 1640 ----LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAE 1695
Query: 4918 QHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQ 4977
Q E ++L E A+ A + + + + + AR + A A Q +
Sbjct: 1696 QELEKQRQLAEGTAQQRLAAEQ-ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKR 1754
Query: 4978 QRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEM 5037
Q L + LA + A+ E+L A A + + ++K K+ + E + L EE
Sbjct: 1755 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL-------AEEA 1807
Query: 5038 TRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETKNP 5097
R + ++ K ++ A + ++ Q RA +R A L G T+++T+
Sbjct: 1808 ARLRALAEE-AKRQRQLAEEDAARQ---------RAEAERVLAEKLAAIGEATRLKTEAE 1857
Query: 5098 RVNLLVSKWQQVWLLALERRRKLNDALDRLEELREFANFDFDIWRKKYMRWMNHKKSRVM 5157
+AL+ + N+ L RL E F R++ K+ +
Sbjct: 1858 --------------IALKEKEAENERLRRLAEDEAFQ-------RRRLEEQAAQHKADIE 1896
Query: 5158 DFFRRIDKDQDGKITRQE-FIDGILSSKFPTSRLEMSAVADIFDRDGDGYIDYYEFVAAL 5216
+ ++ K D ++ RQ+ ++ L + E+ A+ F++ G + + +
Sbjct: 1897 ERLAQLRKASDSELERQKGLVEDTLRQRRQVEE-EILALKASFEKAAAGKAELELELGRI 1955
Query: 5217 HPNKDAYKPITDADKIEDEVTRQVAKCKCAKRFQVEQ 5253
N + + ++E RQ+A + +R + E+
Sbjct: 1956 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEE 1992
Score = 40.0 bits (92), Expect = 0.064
Identities = 84/510 (16%), Positives = 207/510 (40%), Gaps = 52/510 (10%)
Query: 1078 EKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQI-RTPLER 1136
+ E+ K++ ++ L+ + EQE + L + E + + L+ RL + +R
Sbjct: 2168 DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR 2227
Query: 1137 DDLHESVFRITEQ----EKLKKELER----------------LKDDLGTITNKCEEFFSQ 1176
+ E +F + Q KLK +E L+++ + EE
Sbjct: 2228 SQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARL 2287
Query: 1177 AAASSSVPTLRSELNVVLQNMNQVYSMSSTYI-DKLKTVNLVLKNTQAAEALVKLYETKL 1235
+ A+ LR + +++ Q +++ + +K++ V + AE L + E
Sbjct: 2288 SVAAQEAARLRQ---LAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ 2344
Query: 1236 CEEEAVIADKNNI-ENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERD 1294
+ + DK + + L + ++ ++ +RQ + E ++ K EM + +
Sbjct: 2345 EQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAE 2404
Query: 1295 LDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQR 1354
D +++A+++ E+ + ++ ++ + + L + I ++E +
Sbjct: 2405 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKE 2464
Query: 1355 KIQ-ENQPENSKTLATQLNQQKMLVSEIE-MKQSKMDEC------QKYAEQYSATVKD-Y 1405
K+Q E + K+ Q QQ+ L+ E + ++QS + E +++ EQ A ++ +
Sbjct: 2465 KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLF 2524
Query: 1406 ELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRY--------------TALV 1451
+ + + + + QQ+ ++++M+ ++ + R R L
Sbjct: 2525 QDEVAKAQQLREEQQR---QQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE 2581
Query: 1452 TLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPF 1511
Q + + +RL E+ + LEE+ + + ++E+ +KTL + A P
Sbjct: 2582 QQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPA 2641
Query: 1512 SKQKISSEEISTKKEQLSEALQTIQLFLAK 1541
++ + +++ ++ LQ + A+
Sbjct: 2642 AEAEPEHSFDGLRRKVSAQRLQEAGILSAE 2671
Score = 35.0 bits (79), Expect = 2.1
Identities = 73/348 (20%), Positives = 135/348 (38%), Gaps = 54/348 (15%)
Query: 4633 ISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLM-------EWLEESEKSLDSEL 4685
+ V+ W K+ ++ER + L +R + +KL E L +++ L S++
Sbjct: 368 LDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDV 427
Query: 4686 -------------EIANDPDKIKTQLAQ-HKEFQKSLGAKHSVYDTTNRTGRSLKEKTSL 4731
E+ D DK + + + Q +H + R L E+
Sbjct: 428 RLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVA 487
Query: 4732 --ADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEP 4789
+ NL+L ++ + + +SV+R+ +LE++ L LQ L+ W+ E
Sbjct: 488 IRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTL------RYLQDLLAWVE--EN 539
Query: 4790 QLAEDQPVHG-DIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSR----DDSS 4844
Q D G D+ V + +H+ + + + + ++ + +L +R D
Sbjct: 540 QHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLG 599
Query: 4845 WVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHAL---LEWLAEAEQTLRF 4901
+ +Q +L L+ SK A LR E HS V A L WL E E+
Sbjct: 600 RLDLQYAKL---------LNSSK-----ARLRSLESLHSFVAAATKELMWLNEKEEE-EV 644
Query: 4902 HGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHP 4949
D + + + M++LE K ++ + GD +L HP
Sbjct: 645 GFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHP 692
Score = 35.0 bits (79), Expect = 2.1
Identities = 22/51 (43%), Positives = 26/51 (50%)
Query: 5433 EDSGLITTAAARVRTQFADSKKTPSRPGSRAGSKAGSRASSRRGSDASDFD 5483
E +GL AA T+ S + S GS AGS+ GSR SR GS FD
Sbjct: 4461 EGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTGSRTGSRAGSRRGSFD 4511
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 861 bits (2224), Expect = 0.0
Identities = 637/2272 (28%), Positives = 1151/2272 (50%), Gaps = 200/2272 (8%)
Query: 641 EEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKI 700
E+ ++++QDLL WV+E Q ++D EWG DLPSVE+ L +H+ +H++IEEF + ++ A+
Sbjct: 518 EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS 577
Query: 701 SEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE 760
E Q++ + Y + L RL+ QYAKLLN+S+ + R L++LH+FV+ AT EL+WLNEKEE
Sbjct: 578 DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE 637
Query: 761 EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR 820
EEV +DWS+RNTN+ KK+ ++ LMREL+ KE+ IK +Q ++LL E+HPAR T+E+++
Sbjct: 638 EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 697
Query: 821 AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSI 880
AA+QTQWSW+LQLC C+E H+KEN AYF+FF+D +EA L+ L++A++RKYSCDRS+++
Sbjct: 698 AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATV 757
Query: 881 HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ 940
+LEDL+Q++ +EKE+L +YK ++ L +AK ++QLKPR+ P++ +P+ A+CDY+Q
Sbjct: 758 TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 817
Query: 941 IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ 1000
+E+T++K DEC L + + WKV+S +G+EA VPSVCF VPPPN+EA + R+E Q+Q
Sbjct: 818 VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ 877
Query: 1001 NVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFL 1060
++TLWH+ H++MKS+++W L ++ IR+ ++A+ +T+ P E +Q L +L+ ++ FL
Sbjct: 878 ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 937
Query: 1061 EDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLE 1120
DSQ++ F D E+E C +YQ+LL+S E+ QEES ISE+++IRL+LE
Sbjct: 938 RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE 997
Query: 1121 NCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAAS 1180
CE R + ++R PL+++ E RI EQ+K + E+E L + ++ + E+ + S
Sbjct: 998 ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1057
Query: 1181 SSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEA 1240
+ PTLRSEL + L + QV S+S+ Y++KLKT++LV++ TQ AE +++ +E +L E +A
Sbjct: 1058 PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1117
Query: 1241 VIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWH 1300
V A +E ++LK+ R++ + ++ F AL DEL+ A+ + + + + + ERD++ +
Sbjct: 1118 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1177
Query: 1301 KEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQ 1360
+E+ QL+ERWQ V Q D R R+LE +G+ L+YYR++ PL W+Q Q +IQ
Sbjct: 1178 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1237
Query: 1361 PENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQ 1420
+S+ + QL Q++ L+ EIE K++ECQ++A+QY +KDYELQ +TY+A ++
Sbjct: 1238 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLE-PV 1296
Query: 1421 KSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKK 1480
SP K+ ++QS ++ +IQE++DLRT Y+ L TL +QYIKF ++L+R+EEEE+ E+++
Sbjct: 1297 ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRA 1356
Query: 1481 E------HVEKAKELQKWVSNISKTLK-DAEKAGKPPFSKQKISSEEISTKKEQLSEALQ 1533
E VE A E Q+ ++ K AE+ K Q+ EE+ ++E +A Q
Sbjct: 1357 EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAK---ELQQRMQEEVVRREEAAVDAQQ 1413
Query: 1534 TIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKI-V 1592
++ ++++++ L++S +Q + ++ S +++EE+I V
Sbjct: 1414 ----------------QKRSIQEELQQLRQSSEAEIQAKARQAEAAERS-RLRIEEEIRV 1456
Query: 1593 AERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQ--EELQKDMQGS 1650
Q E E+ +G + G +A E +K Q+++ E L++ +Q
Sbjct: 1457 VRLQLEATERQRGGAE----------GELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1506
Query: 1651 AQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVT 1710
+Q + + +K E ++ +AL Q L E +++ E+ + Q++ E + V
Sbjct: 1507 SQRKRQAEVELASRVKAEAEAAREKQRAL--QALEELRLQAEEAERRLRQAEVERARQVQ 1564
Query: 1711 TAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDG 1770
A+ ET + +A +L+ + L ++ A + ++ E+ Q+ +
Sbjct: 1565 VAL--ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ--QQAEA 1620
Query: 1771 KSAIGE-EDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQ 1829
+ A E E E+ L+ + ++ E + QQ +A+ EK + A+
Sbjct: 1621 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK----------QKEEAE 1670
Query: 1830 VLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEF 1889
++G+ EE+ Q+ + E ++ + LAE + +L + ++EL + A+ +
Sbjct: 1671 REARRRGK---AEEQAVRQRELAEQELEKQRQLAEGTAQQRL--AAEQELIRLRAETEQG 1725
Query: 1890 EHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAK 1949
E Q E+EL L+ A ++++ ++ + ++ + S R E ++
Sbjct: 1726 EQQRQLLEEELARLQREA------AAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1779
Query: 1950 SCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCG 2009
S S++ +++ A R+L R R+L + ++ D + +A
Sbjct: 1780 STSEKSKQRLEAEAGR---FRELAEEAARLRALAEEAKRQRQLAEE--DAARQRAEAERV 1834
Query: 2010 LLAGLQAC-EATASKHLSEPIAVDPKNLQ----RQLEETKALQGQISSQQVAVEKLKKTA 2064
L L A EAT K +E IA+ K + R+L E +A Q + +Q A K
Sbjct: 1835 LAEKLAAIGEATRLKTEAE-IALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHK----- 1888
Query: 2065 EVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEML 2124
D L + L+ G ED + + E++ L+++ ++
Sbjct: 1889 ---ADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEI-------LALKASFEKAA 1938
Query: 2125 DWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDP 2184
G E L E G++ N+ +D + E + A RQ + A E+ ++ E
Sbjct: 1939 --AGKAELEL-ELGRIRSNA---EDTLRSKEQAELE-AARQRQLAAEEERRRREAE---- 1987
Query: 2185 STASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALT 2244
+ K L+A EA+ + K L ++E LK KVE L E+ + + Q
Sbjct: 1988 ------ERVQKSLAAE-EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ 2040
Query: 2245 EVDVPGKDVTE------LSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLE 2298
E E + Q QE + + L+ L + +++A V +
Sbjct: 2041 EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARV-Q 2099
Query: 2299 KTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGA 2358
++ +++E+ + K+ A Q + A K K +E ++ Q +
Sbjct: 2100 AEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQ 2159
Query: 2359 EDLGKS-LEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLN 2417
+ + +E KK E+ + ++++ ++ L T K + + L
Sbjct: 2160 KQAADAEMEKHKKFAEQTLRQKAQVEQ----ELTTLRLQLEETDHQKNL--LDEELQRLK 2213
Query: 2418 GEGTATNTEEFWANKGLTSIKKDMTDISH-----GYEDLGLLLKDKIAELNTKLSKLQKA 2472
E T + + L S++ M ++S E+ L+L+DK NT+ +
Sbjct: 2214 AEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKD---NTQ----RFL 2266
Query: 2473 QEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQE---L 2529
QEE+ M Q ++ + + Q+ A A + +Q E LK+ + VQE L
Sbjct: 2267 QEEAEKMKQVAEEAARLSVAAQEA-ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2325
Query: 2530 KDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQ-TVE 2588
K + ELL++ + + ++ +L D++Q ++ + FQ T+E
Sbjct: 2326 KAE-AELLQQQKELAQ---------------EQARRLQEDKEQMAQQLAEETQGFQRTLE 2369
Query: 2589 AQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILS 2648
A+ ++ L ++ + +++++ + E + + + E+ +
Sbjct: 2370 AERQRQL------------------EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE 2411
Query: 2649 RPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSD 2708
GE + ++ + Q + Q + + +AI + + + L+
Sbjct: 2412 EIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ------- 2464
Query: 2709 LDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCED----LSALVKEE 2764
+ KL + Q L+ Q ++Q EK + + E L L ++E
Sbjct: 2465 -EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDE 2523
Query: 2765 YLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQN 2824
KA+ R+ + + + +EQ+ + V ++ A H+ ++ R Q L ++++
Sbjct: 2524 VAKAQQLREEQ--QRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRR 2581
Query: 2825 KSHPISA--------KLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLL 2868
+ + A +L +LE + S+ +TA KT+ G + L
Sbjct: 2582 QQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDAL 2633
Score = 563 bits (1452), Expect = e-159
Identities = 270/450 (60%), Positives = 361/450 (80%), Gaps = 1/450 (0%)
Query: 71 DERDKVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEVLSGDTLPREKGRMRF 130
DERD+VQKKTFTKW+N+HL+K ++H++DLYEDLRDGHNLISLLEVLSGD+LPREKGRMRF
Sbjct: 38 DERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRF 97
Query: 131 HRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIHVTGESED 190
H+LQNVQIALDYL+ RQVKLVNIRNDDI DGNPKLTLGLIWTIILHFQISDI V+G+SED
Sbjct: 98 HKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSED 157
Query: 191 MSAKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAVQSNLA 250
M+AKE+LLLW+Q+ EGY G+RC+NFT+ WRDG+LFNAIIH+++P LIDMN V Q+NL
Sbjct: 158 MTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLE 217
Query: 251 NLEHAFYVAEK-IGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAFPKVPEGGEGIGANDV 309
NL+ AF VAE+ +GV RLLDPEDVDV PDEKS+ITYVSSLYDA P+VP+ +G+ AN++
Sbjct: 218 NLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANEL 277
Query: 310 EVKWIEYQNMVNYLIQWIRHHVTTMSERTFPNNPVELKALYNQYLQFKETEIPPKETEKS 369
+++W EY+ +V L+QW+RHH ER FP++ E++ L++Q+L+FKE E+P KE +K+
Sbjct: 278 QLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKN 337
Query: 370 KIKRLYKLLEIWIEFGRIKLLQGYHPNDIEKEWGKLIIAMLEREKALRPEVERLEMLQQI 429
+ K +Y+ LE ++ G++K+ GYHP D+EKEWGKL +A+LEREK LR E ERLE LQ+I
Sbjct: 338 RSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRI 397
Query: 430 ANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLLRQHVIDVQ 489
++Q ++ +CE++L A LQSD + L +G Q E+ + + ++++R DVQ
Sbjct: 398 VTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQ 457
Query: 490 ILIDGKYYQADQLVQRVAKLRDEIMALRNE 519
L DG++ Q +Q+ +RV +L + ++A+R E
Sbjct: 458 TLKDGRHPQGEQMYRRVYRLHERLVAIRTE 487
Score = 111 bits (277), Expect = 2e-23
Identities = 355/1874 (18%), Positives = 725/1874 (38%), Gaps = 306/1874 (16%)
Query: 2676 GQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQK 2735
G S + Q++ + Q +S + +L D+ +L + + H + E A++
Sbjct: 959 GSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARE 1018
Query: 2736 MKQEI-QQEKKQIKVA---------QALCEDLSALVKEEYLKAELSRQLEGILKSFKDVE 2785
Q I +Q+K Q +V A E + AL + L +LE L + V
Sbjct: 1019 CAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVR 1078
Query: 2786 QKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKD 2845
+ +++ L++ Q +A + KE Q + A L LE+ K
Sbjct: 1079 SLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQ----AVPATLPELEAT----KA 1130
Query: 2846 FSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQ----------------LNTIKTN 2889
K L AQ+ + T + L + +G+++ +LQ + +
Sbjct: 1131 SLKKLRAQAEAQQPTF---DALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLER 1187
Query: 2890 WDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFC--LDPAEGENS 2947
W Q R+ +L++ + Y+E + L W+ + E+I+ D
Sbjct: 1188 WQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQ 1247
Query: 2948 IAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSK 3007
+ + ++L +E+++H VE A ++ K
Sbjct: 1248 LRQEQALLEEIERHGEKVEECQRFAKQYINAI---------------------------K 1280
Query: 3008 KFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQA 3067
+ L+ +T K + S K ++Q E + I + + + + ++ T+ K +
Sbjct: 1281 DYELQLVTYKAQLEPVASPAKKPKVQSGSESV-IQEYVDLRTHYSELTTLTSQYIKFISE 1339
Query: 3068 LKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVET-IAQEHSTLSQQVDEKCSFLETKLQG 3126
+++ +RLA+ E + + L+ + +A+ H+ Q + + L+ ++Q
Sbjct: 1340 TLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ- 1398
Query: 3127 IGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKET-IKAFLKKLEALMASNDNA 3185
E+ + D + + + L++ E I+A ++ EA S
Sbjct: 1399 --------EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRI 1450
Query: 3186 NKTCKMM-LATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKL 3244
+ +++ L E T G + +L+AL +AR E+ E ++ +E +L
Sbjct: 1451 EEEIRVVRLQLEATERQRGGAEGELQAL-----------RARAEEAEAQKRQAQEEAERL 1499
Query: 3245 KEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLI 3304
+ + +ESQ E E ++ K E E + KQ+ + L + +
Sbjct: 1500 RR--------QVQDESQRKRQAEVELASRV--------KAEAEAAREKQRALQALEELRL 1543
Query: 3305 QSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVD 3364
Q+ + L + +RA Q+Q AL
Sbjct: 1544 QAEEAE-----------------RRLRQAEVERARQVQVAL------------------- 1567
Query: 3365 TEELVANQKPPSAEFKVVKAQIQEQKL-LQRLLDDRKSTVEVIKREGEKIATTAEPADKV 3423
Q+ AE + +A E+ L+R L + V ++ E E+ A A++
Sbjct: 1568 ----ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERA 1623
Query: 3424 KILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEP 3483
+ + L RW+ N+A Q E VAQQ + L + EK+ E
Sbjct: 1624 REEAEREL--ERWQLKANEALRLRLQAEE---VAQQ-----KSLAQ--AEAEKQKEEAER 1671
Query: 3484 IGTQASKLEEQIAQHKALEDDIINHNKHLHQAVS---IGQSLKVLSSREDKDMVQSKLDF 3540
+ K EEQ + + L + + + L + + + +++ R + + + +
Sbjct: 1672 EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL 1731
Query: 3541 SQVWYIEIQEKSHSRSELLQQALCN-AKIFGEDEVELMNWLN--EVHDKLSKLSVQDYST 3597
+ +Q ++ + ++ Q+ AK+ E EV L + E S+ S Q
Sbjct: 1732 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1791
Query: 3598 EG-----LWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKA 3652
E L ++ + LR L E+ ++Q ++ + +Q E ++ +KL AI
Sbjct: 1792 EAGRFRELAEEAARLRALAEEAKRQRQLAEE------DAARQRAEAE-RVLAEKLAAIG- 1843
Query: 3653 RYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQA 3712
+ T+L T+ L++ RL E+ ++E + ++ + E A
Sbjct: 1844 ---EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI----EERLA 1896
Query: 3713 QMRPKELKKEAKNNKALL-DSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTIT 3771
Q+R K E + K L+ D+L + E++ +A EK A E
Sbjct: 1897 QLR-KASDSELERQKGLVEDTLRQRRQVEEEILALKA--SFEKAAAGKAEL--------- 1944
Query: 3772 QKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTME 3831
E++ +RS D E + + ++ ++ + E+ + A+ +VQK+ E
Sbjct: 1945 ----ELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEE---ERRRREAEERVQKSLAAE 1997
Query: 3832 ---ILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLE- 3887
+ K ++++ + K+ EE + ++++ ++ + Q +++ LQ E
Sbjct: 1998 EEAARQRKAALEEVERLKAKV------EEARRLRERAEQESARQLQLAQEAAQKRLQAEE 2051
Query: 3888 RAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPH 3947
+A + Q E +EL L + QS++ QL A E R+ EE + R
Sbjct: 2052 KAHAFAVQQKE--QELQQTLQQEQSVLDQLRGEA---EAARRAAEEAEEARVQAEREAAQ 2106
Query: 3948 IDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQST----- 4002
+ + +L + + + + + AA+ L + +++ +RA A A+ Q
Sbjct: 2107 SRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAE 2166
Query: 4003 -QFHDK-----------IDQILESLE-RIVERLRQPPSISAEVEKIKEQISENK------ 4043
+ H K ++Q L +L ++ E Q + E++++K + +E
Sbjct: 2167 MEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQV 2226
Query: 4044 -----NVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHT 4098
+V V ME+L L ++ +I R DKD + + +Q++ ++M + E
Sbjct: 2227 EEELFSVRVQMEELSKLKARIEAENRALILR----DKDNTQRFLQEEAEKMKQVAEEAAR 2282
Query: 4099 L-VEEREAKLLDVMELAEKFWCDHMSLIVT-IKDTQDFIRDLEDPGIDPSVVKQQQEAAE 4156
L V +EA L +LAE+ +L +K+ +++ + +++QQ+E A+
Sbjct: 2283 LSVAAQEAARL--RQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ 2340
Query: 4157 TIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKL 4216
E+ LQE+ + ++ E + + E + +A + ++ ++
Sbjct: 2341 ---EQARRLQEDKE-------QMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKL-RV 2389
Query: 4217 EEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQI 4276
E +A + ++ Q + G KL + T+ Q +E I
Sbjct: 2390 AEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE-------------I 2436
Query: 4277 EMERLNHQAELLLKKVTE-ESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQ 4335
+ ++ +H AE L + + E E +K +Q E KL+ EE +Q +L AL Q
Sbjct: 2437 QRQQSDHDAERLREAIAELEREKEKLQQ---EAKLLQLKSEEMQTVQQEQLLQETQALQQ 2493
Query: 4336 FQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEI----ELAKHHVLQNDVLAHQSTVEAV 4391
++L+ + LL ++ + + +E E+AK L+ + Q +E
Sbjct: 2494 ---------SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQE 2544
Query: 4392 NKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIED 4451
+ L+ S EEA Q++ E +R Q L++ EQ+++Q + L + + + +
Sbjct: 2545 RQR---LVASM--EEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEE---NQRLRE 2596
Query: 4452 LQQWLTDTERHLLA 4465
Q L + R LA
Sbjct: 2597 QLQLLEEQHRAALA 2610
Score = 94.0 bits (232), Expect = 4e-18
Identities = 353/1847 (19%), Positives = 705/1847 (38%), Gaps = 283/1847 (15%)
Query: 3201 DLVGIKRDLEALSKQCNKLLDRAQ--AREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHE 3258
D + +R+ + S +LL + A+EE R + S+LK+ + L+ E
Sbjct: 950 DRLMAEREYGSCSHHYQQLLQSLEQGAQEES------RCQRCISELKDIRLQLEACETRT 1003
Query: 3259 ESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAK--------- 3309
+ + ++ E + + I Q Q +V LG+G+ + +A+
Sbjct: 1004 VHRLRLPLDKEPARECA--------QRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPE 1055
Query: 3310 -STSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEEL 3368
S + L +L+ + + + A +L+ L Q A E L + +E
Sbjct: 1056 PSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEA 1115
Query: 3369 VA------NQKPPSAEFKVVKAQIQ-EQKLLQRLLDDRKSTVEVIKREGEKIATTAEPAD 3421
A + A K ++AQ + +Q L D+ + EV +R ++ +
Sbjct: 1116 QAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVE 1175
Query: 3422 KVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNC 3481
+ + ++++ L RW+A+L + + R R+LE + + + E+ +PL WL +R
Sbjct: 1176 RWR--ERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQI 1233
Query: 3482 EPIGTQASK-LEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDF 3540
+ + S+ + EQ+ Q +AL ++I H + + + + + +V K
Sbjct: 1234 QAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQL 1293
Query: 3541 SQVWYIEIQEKSHSRSELLQQALCNAKI-FGEDEVELMNWLNEVHDKLSKLSVQDYSTEG 3599
V + K S SE + Q + + + E ++ + + L ++ ++ E
Sbjct: 1294 EPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE- 1352
Query: 3600 LWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITK 3659
+Q++E R R V+ AL +L + Q K +A + + +
Sbjct: 1353 --QQRAEERE-------RLAEVEAALEKQRQLAEAHA-------QAKAQAEREAKELQQR 1396
Query: 3660 LSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKEL 3719
+ +V + E A+ ++ S EEL E E+ + K +A A+ +
Sbjct: 1397 MQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQA------KARQAEAAERSRLRI 1450
Query: 3720 KKEAKNNKALLDSL-NEVSSALLELVPWRAR----EGLEKMVAEDNERYRLVSDTITQKV 3774
++E + + L++ + A EL RAR E ++ E+ ER R +Q+
Sbjct: 1451 EEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRK 1510
Query: 3775 EEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILR 3834
+ + + AE E ++ L +L ++RL+ ++ +L+ E+ R
Sbjct: 1511 RQAEV------ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR-----QAEVER 1559
Query: 3835 HKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVN 3894
+ V+ + +E E QS + +E+ QLER+
Sbjct: 1560 ARQ-----VQVALETAQRSAEAELQSKRASF--------------AEKTAQLERS----- 1595
Query: 3895 QFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKT 3954
L E ++QL E E QQQ E + RE E + +++
Sbjct: 1596 ------------LQEEHVAVAQLRE---EAERRAQQQAEAERARE---EAERELERWQLK 1637
Query: 3955 GPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILES 4014
+ L L Q+K +A Q KE+ ++ A +A Q+ + + +Q LE
Sbjct: 1638 ANEALRLRLQAEEVAQQKSLAQAEAEKQ-KEEAEREARRRGKAEEQAVRQRELAEQELEK 1696
Query: 4015 LERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTD 4074
++ E Q ++AE E I+ + + E+ + L E R + A +
Sbjct: 1697 QRQLAEGTAQ-QRLAAEQELIRLRAETEQG-----EQQRQLLEEELARLQREAAAATQKR 1750
Query: 4075 KDISAKAVQDKLDQMVFIWENIHTLVEER----------EAKLLDVMELAEKFWCDHMSL 4124
+++ A+ + + + V + E R EA+ ELAE+ +
Sbjct: 1751 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE-----AAR 1805
Query: 4125 IVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQE------ELDIVI---NL 4175
+ + + R L + +Q+ EA + E++ + E E +I +
Sbjct: 1806 LRALAEEAKRQRQL----AEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEA 1861
Query: 4176 GSELIAACGEPDKPIVKKSIDE--------LNSAWDSLNKAWKDRIDK----LEEAMQAA 4223
+E + E D+ ++ ++E + L KA +++ +E+ ++
Sbjct: 1862 ENERLRRLAE-DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQR 1920
Query: 4224 VQYQDGLQAV-FDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQ---IEME 4279
Q ++ + A+ + A GK +G + + +Q + EA +Q+ E E
Sbjct: 1921 RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE 1980
Query: 4280 RLNHQAELLLKK--VTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQ 4337
R +AE ++K EE + L E++ + +EE R+ + + L Q
Sbjct: 1981 RRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ 2040
Query: 4338 HALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAH-QSTVEAVNKAGN 4396
A + L +QK E EL + + VL + EA +A
Sbjct: 2041 EAAQKRLQAEEKAHAFAVQQK---------EQELQQTLQQEQSVLDQLRGEAEAARRAAE 2091
Query: 4397 DLIES--SAGEEASNLQNKLEVLNQRWQNVLEKTEQ-----------RKQQLDGALRQAK 4443
+ E+ A EA+ + ++E + Q+ E+ + RK+ A R+A+
Sbjct: 2092 EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQ 2151
Query: 4444 GFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEET--YKSLM 4501
+ Q + E+H ++ +T +++ V E+ EET K+L+
Sbjct: 2152 AEQAALRQKQAADAEMEKHKKFAE------QTLRQKAQVEQELTTLRLQLEETDHQKNLL 2205
Query: 4502 QKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNE---RKTKLE-EALNLAMEFHNS 4557
+ Q L K+ T + + ++E+ SV ++ E K ++E E L + ++
Sbjct: 2206 DEELQRL----KAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDN 2261
Query: 4558 LQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLK 4617
Q F+ +AE+ VA + L + + A E + + + E K
Sbjct: 2262 TQRFLQ--EEAEKMKQVAEEAAR-LSVAAQEAARLRQLAEEDLAQQRALAE--------K 2310
Query: 4618 YFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSL-DDARKRAKQFHEAWSKLMEWLEE 4676
+K V L + ++ + E+ R L +D + A+Q E LE
Sbjct: 2311 MLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA 2370
Query: 4677 SEKSLDSELEIANDPDKIKTQLAQ--------HKEFQKSLGAKHSVYDTTNRTGRSLKEK 4728
+ +LE++ + +++K ++A+ ++ Q+ + + +RT + +EK
Sbjct: 2371 ERQ---RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEK 2427
Query: 4729 TSLAD-----------DNLKLDDMLSELRDKWDTICG-------KSVERQNKLEEALLFS 4770
+L D +L + ++EL + + + KS E Q +E LL
Sbjct: 2428 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLL-- 2485
Query: 4771 GQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKR 4830
Q T ALQ +L + L ++ + + + L + A ++L + Q
Sbjct: 2486 -QETQALQQ--SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2542
Query: 4831 SARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLE 4890
R+ + S +++ + + +E R + + +LE RQ EE
Sbjct: 2543 QERQRLVASMEEARRRQHEAEEGVRRKQ-------EELQQLEQQRRQQEEL--------- 2586
Query: 4891 WLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKAT 4937
LAE Q LR + L+ L +QH+ + EE A AT
Sbjct: 2587 -LAEENQRLR---------EQLQLLEEQHRAALAHSEEVTASQVAAT 2623
Score = 85.1 bits (209), Expect = 2e-15
Identities = 295/1541 (19%), Positives = 608/1541 (39%), Gaps = 226/1541 (14%)
Query: 3708 EASQAQMRPKELKKEAKNNKALLDSLN-------EVSSAL--------LELVPWRAREGL 3752
EA++A + K+L+ +A+ + D+L EV L +E+ WR R
Sbjct: 1126 EATKASL--KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRER--- 1180
Query: 3753 EKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIR 3812
VA+ ER++ V + E++ + + + ++AD +W+ + ++ + +
Sbjct: 1181 ---VAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1237
Query: 3813 LEQDQT-SAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQ--SMKKKLDKVL 3869
L Q QL+ ++ EI RH + +++ + + + A + E Q + K +L+ V
Sbjct: 1238 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA 1297
Query: 3870 KNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQ 3929
+ + QS + Y +L +E ++ SQ ETLR+
Sbjct: 1298 SP------------AKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIK--FISETLRR 1343
Query: 3930 QQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKK 3989
+EE R + AE + + ++ + +L+ + + A L +++E+V +
Sbjct: 1344 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1403
Query: 3990 RAVALDEAISQSTQFHDKIDQILESLERIVE-RLRQPPSISAEVEKIKEQISENKNVSVD 4048
R A +A Q +++ Q+ +S E ++ + RQ + +I+E+I
Sbjct: 1404 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR-------- 1455
Query: 4049 MEKLQPLYETLKQRG----EEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEERE 4104
+ +LQ L T +QRG E R+ + + + Q++ +++ + +E +
Sbjct: 1456 VVRLQ-LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLR------RQVQDESQ 1508
Query: 4105 AKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIRE-EID 4163
K +ELA + + + ++ Q ++ LE+ + Q +EA +R+ E++
Sbjct: 1509 RKRQAEVELASRVKAEAEAA----REKQRALQALEELRL------QAEEAERRLRQAEVE 1558
Query: 4164 GLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWD-SLNKAWKDRIDKLEEAMQA 4222
++ + + E E + + S E + + SL + EEA +
Sbjct: 1559 RARQ-----VQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERR 1613
Query: 4223 AVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLN 4282
A Q + +A + A +L + ++ Q EE+ Q KS A Q E E+
Sbjct: 1614 AQQQAEAERAREE----AERELERWQLKANEALRLRLQAEEVAQQKSLA---QAEAEKQK 1666
Query: 4283 HQAELLLKKVTEESDKHTVQDPLMELKLIWD-SLEERIINRQHKLEGALLALG------- 4334
+AE ++ + ++ Q L E +L L E ++ E L+ L
Sbjct: 1667 EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1726
Query: 4335 QFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKA 4394
Q + L+E LA L ++++ + +E ELAK +LA ++ E +++
Sbjct: 1727 QQRQLLEEELARLQREAAAATQKR------QELEAELAKVRAEMEVLLASKARAEEESRS 1780
Query: 4395 GNDL----IESSAG------EEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKG 4444
++ +E+ AG EEA+ L+ E ++ Q E +++ + + L +
Sbjct: 1781 TSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLA 1840
Query: 4445 FHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKG 4504
GE L+ TE + + E E+L + AF+ + ++ K
Sbjct: 1841 AIGEATRLK-----TEAEIALKEK-----EAENERLR-RLAEDEAFQRRRLEEQAAQHKA 1889
Query: 4505 --QQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFI 4562
++ LA+ K++++ +++ VE L +R+ EE L L F +
Sbjct: 1890 DIEERLAQLRKASDSELERQKG-------LVEDTLRQRRQVEEEILALKASFEKAAAG-- 1940
Query: 4563 NWLTQAEQTLNVASRPSLILDTV-------LFQIDEHKVFANEVNSHREQIIELDKTGTH 4615
+AE L + S DT+ L + ++ A E RE + K+
Sbjct: 1941 ----KAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAA 1996
Query: 4616 LKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLE 4675
+ ++++ L + V+RL + R+RA+Q E+ +L E
Sbjct: 1997 EEEAARQRKAAL-------------EEVERLKAKVEEARRLRERAEQ--ESARQLQLAQE 2041
Query: 4676 ESEKSLDSELEIANDPDKIKTQLAQHKE--FQKSLGAKHSVYDTTNRTGRSLKEKTSLAD 4733
++K L +E +K Q KE Q++L + SV D + + A+
Sbjct: 2042 AAQKRLQAE-------EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE 2094
Query: 4734 D-NLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLA 4792
+ ++ + ++ R + VE +L+++ Q QA + L + Q A
Sbjct: 2095 EARVQAEREAAQSR--------RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2146
Query: 4793 E-----DQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVK 4847
+Q ++ HK F ++ ++ + V+ + R +E + + +
Sbjct: 2147 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2206
Query: 4848 VQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPD 4907
++Q L + L + Q EE L+ EAE ++
Sbjct: 2207 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSK-----LKARIEAEN----RALILR 2257
Query: 4908 DEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFE 4967
D+D + + + E MK++ E+ A L+ A + + D + RA E
Sbjct: 2258 DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED--------LAQQRALAE 2309
Query: 4968 EVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALI 5027
++L K+ Q + A L A+ ELL+ Q L + +++ Q EE +
Sbjct: 2310 KML---KEKMQAVQEA-TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGF- 2364
Query: 5028 AEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSG 5087
Q +E ++Q ++ + K R A+ S Q+ + A R R A +
Sbjct: 2365 ---QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA----EEDAQRFRKQAEEIGEKL 2417
Query: 5088 SQTQIETKNPRVNLLVSKWQQVWLLALERRR------KLNDALDRLEELREFANFDFDIW 5141
+T++ T+ K V L ++R++ +L +A+ LE +E + +
Sbjct: 2418 HRTELATQ--------EKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL 2469
Query: 5142 RKKYMRWMNHKKSRVMDFFRRIDK----DQDGKITRQEFID 5178
+ K ++ +++ + + + ++D + R+ FI+
Sbjct: 2470 QLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE 2510
Score = 78.6 bits (192), Expect = 2e-13
Identities = 352/1885 (18%), Positives = 731/1885 (38%), Gaps = 251/1885 (13%)
Query: 3336 QRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRL 3395
QR +L+++ L L+ LL+W+ + + V + + V+AQ+ + L +
Sbjct: 512 QRRPELEDSTLRY------LQDLLAWVEENQHRVDGAEW-GVDLPSVEAQLGSHRGLHQS 564
Query: 3396 LDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGI-S 3454
+++ ++ +E + + +++ PA + L LD ++ LLN ++ R R LE + S
Sbjct: 565 IEEFRAKIERARSDEGQLS----PATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHS 620
Query: 3455 VVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQ 3514
VA E + WL E+ V + + + + + + AL ++ K + +
Sbjct: 621 FVAAATKELM-----WLNEKEEEEVGFD-WSDRNTNMTAKKESYSALMRELELKEKKIKE 674
Query: 3515 AVSIGQSL--KVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGED 3572
+ G L + +R + Q+ L W +LQ C
Sbjct: 675 LQNAGDRLLREDHPARPTVESFQAALQTQWSW-------------MLQLCCC-------- 713
Query: 3573 EVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQ-ALLNGLEL 3631
E H K + Q +S + + + +L+ LQE L RK + D+ A + LE
Sbjct: 714 --------IEAHLKENAAYFQFFS--DVREAEGQLQKLQE-ALRRKYSCDRSATVTRLED 762
Query: 3632 LKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDK 3691
L Q DE +++L K + +AK + +QL R H H
Sbjct: 763 LLQDAQDE----KEQLNEYKGHL-------SGLAKRAKAVVQLKPR-HPAHPMRGRLPLL 810
Query: 3692 VEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVS-SALLELVPWRARE 3750
+ E V KG+E + + K L S +E + ++ LVP +E
Sbjct: 811 AVCDYKQVEVTVHKGDECQLVG------PAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQE 864
Query: 3751 GLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGD 3810
E + + + LV T+ ++ ++L Q + SW T + L
Sbjct: 865 AQEAVTRLEAQHQALV--TLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKP--- 919
Query: 3811 IRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLK 3870
EQ Q L+ L ++ + D +G E++ +++
Sbjct: 920 --EEQRQALHSLE---------LHYQAFLRDSQDAG-----GFGPEDRLMAEREYGSCSH 963
Query: 3871 NYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQ 3930
+Y + Q + + R Q +++ + +L T T + +L P
Sbjct: 964 HYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRT---VHRLRLPL--------D 1012
Query: 3931 QEEHRQLRELIAEHKPHIDKMNKTGPQLLELS--PGEGFSIQEKYVAADTLYSQIKEDVK 3988
+E R+ + IAE + ++ G + LS + ++ E AA TL S+++ +
Sbjct: 1013 KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLG 1072
Query: 3989 KRAVALDEAISQSTQFHDKIDQIL----------ESLERIVERLRQPPSISAEVEKIKEQ 4038
K L++ S S + +K+ I E L E+L++ ++ A + +++
Sbjct: 1073 K----LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEAT 1128
Query: 4039 ISENKNVSVDMEKLQPLYETLKQR-------GEEMIARSGGTDKDISAKAVQDKLDQMVF 4091
+ K + E QP ++ L+ GE + R G ++D+ + ++++ Q++
Sbjct: 1129 KASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHG--ERDVEVERWRERVAQLLE 1186
Query: 4092 IWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLED-PGIDPSVVKQ 4150
W+ + + R+ +L + + L ++D + ++ P D V++
Sbjct: 1187 RWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVRE 1246
Query: 4151 QQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIV--KKSID---------ELN 4199
Q + + EEI+ E+++ + I A + + +V K ++ ++
Sbjct: 1247 QLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQ 1306
Query: 4200 SAWDSLNKAWKDRIDKLEEAMQAAVQY----QDGLQAVFDWVDIAGGKLAS----MSPIG 4251
S +S+ + + D E QY + L+ + + +A + A ++ +
Sbjct: 1307 SGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVE 1366
Query: 4252 TDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKK---VTEESDKHTVQDPLMEL 4308
LE +Q E Q K++A ++ E+++ Q E++ ++ V + K ++Q+ L +L
Sbjct: 1367 AALEKQRQLAEAHAQAKAQAEREAKELQQ-RMQEEVVRREEAAVDAQQQKRSIQEELQQL 1425
Query: 4309 KLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIE 4368
+ S E I + + E A + + + + + L TE + GG ++
Sbjct: 1426 R---QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATE------RQRGGAEGELQ 1476
Query: 4369 IELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEE---ASNLQNKLEVLNQRWQNVL 4425
A+ + Q E + + D + E AS ++ + E ++ Q L
Sbjct: 1477 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREK-QRAL 1535
Query: 4426 EKTEQRKQQLDGALRQAKGFHGEIE---DLQQWLTDTERHL---LASKPLGGLPETAKEQ 4479
+ E+ + Q + A R+ + E+E +Q L +R L SK +TA+ +
Sbjct: 1536 QALEELRLQAEEAERRLR--QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE 1593
Query: 4480 LNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNE 4539
++ E A + +EE + Q+ + AR E E +L
Sbjct: 1594 RSLQEEHVAVAQLREEAERRAQQQAEAERAR--------------------EEAERELER 1633
Query: 4540 RKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEV 4599
+ K EAL L ++ Q +AE+ A R + Q + A +
Sbjct: 1634 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1693
Query: 4600 NSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKR 4659
+ Q+ E GT + + +Q+++ ++ + + + + + L R A ++
Sbjct: 1694 LEKQRQLAE----GTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK 1749
Query: 4660 AKQFHEAWSKL---MEWLEESEKSLDSELEIANDPDK--IKTQLAQHKEFQKSLGAKHSV 4714
++ +K+ ME L S+ + E ++ K ++ + + +E + ++
Sbjct: 1750 RQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRAL 1809
Query: 4715 YDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFT 4774
+ R R L E+ + A + + +L+E G++ + + E AL
Sbjct: 1810 AEEAKRQ-RQLAEEDA-ARQRAEAERVLAEKL----AAIGEATRLKTEAEIALKEKEAEN 1863
Query: 4775 DALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARE 4834
+ L+ L + + + E+Q D+ L KA EL ++ V+ R R+
Sbjct: 1864 ERLRRLAE-DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQ 1922
Query: 4835 L------IEGSRDDSSWVKVQMQ-ELS-TRWETVCALSISKQTRLEAALRQ---AEE--- 4880
+ ++ S + ++ K +++ EL R L +Q LEAA ++ AEE
Sbjct: 1923 VEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERR 1982
Query: 4881 FHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRA-ELNKATTM 4939
+ + LA E+ R ++ + L+ +++ + ++ E++ A +L A
Sbjct: 1983 RREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA 2042
Query: 4940 GDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQ----QRLASALAGLIAKQELLE 4995
L K ++ + +E+ +Q Q Q A A A +E E
Sbjct: 2043 AQKRLQ-------AEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2095
Query: 4996 A-LLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRR 5054
A + A + A++ ++ E + Q EE A+ Q E++ RK+ + + +R
Sbjct: 2096 ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL-RKEAEQEAA----RRA 2150
Query: 5055 AADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGS--------QTQIETKNPRVNLLVSKW 5106
A+ ++L+ D K+F +L + Q+E + + NLL +
Sbjct: 2151 QAEQAALRQK-QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEEL 2209
Query: 5107 QQVWLLALERRRKLNDALDRLEELR 5131
Q++ A E R+ + + L +R
Sbjct: 2210 QRLKAEATEAARQRSQVEEELFSVR 2234
Score = 69.3 bits (168), Expect = 1e-10
Identities = 208/1057 (19%), Positives = 422/1057 (39%), Gaps = 142/1057 (13%)
Query: 4258 KQQIEELKQFKSEAYQQQIEME-------RLNHQAELLLKKVTEESDKHTVQDPLMELKL 4310
K+ E Q +E + Q E+E RL+ +AE +L T++ EL+L
Sbjct: 1013 KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRS---ELEL 1069
Query: 4311 IWDSLEE-RIINRQH--KLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAI 4367
LE+ R ++ + KL+ L + Q A + L A E L E + V +
Sbjct: 1070 TLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAH----EEQLKEAQAVPATLPEL 1125
Query: 4368 EIELAKHHVLQNDVLAHQSTVEAVN------KAGNDLIESSAGE---EASNLQNKLEVLN 4418
E A L+ A Q T +A+ + + ++ GE E + ++ L
Sbjct: 1126 EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLL 1185
Query: 4419 QRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTER--HLLASKPLGGLPETA 4476
+RWQ VL +T+ R+++L+ RQ + + + L WL D R + + PL +
Sbjct: 1186 ERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLAD-SQAV 1244
Query: 4477 KEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETK 4536
+EQL +E+ +++ + + C + A+ Q IN +K+ E +
Sbjct: 1245 REQLR-----------QEQALLEEIERHGEKVEECQRFAK----QYINAIKD----YELQ 1285
Query: 4537 LNERKTKLEEALNLAME------FHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQID 4590
L K +LE + A + + +Q++++ T + + S+ + L +++
Sbjct: 1286 LVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRME 1345
Query: 4591 EHKVFAN-----------EVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRW 4639
E + A EV + E+ +L + K ++++ L + + V R
Sbjct: 1346 EEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRRE 1405
Query: 4640 EKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLA 4699
E V ++ RS+ + ++ +Q EA ++ ++E + S L I + ++ QL
Sbjct: 1406 EAAVDAQQQK-RSIQEELQQLRQSSEA--EIQAKARQAEAAERSRLRIEEEIRVVRLQL- 1461
Query: 4700 QHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVER 4759
+ E Q+ GA+ + R + +K ++ + + +++D+ VE
Sbjct: 1462 EATERQRG-GAEGELQALRARAEEAEAQKRQAQEE---AERLRRQVQDESQRKRQAEVEL 1517
Query: 4760 QNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDID----LVMNLIDNHKAFQ 4815
++++ + + ALQAL + R++ + AE + +++ + + L ++ +
Sbjct: 1518 ASRVKAEAEAAREKQRALQALEE--LRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1575
Query: 4816 KELGKRTSS----VQALKRSARE---LIEGSRDDSSWVKVQMQELS----------TRWE 4858
EL + +S L+RS +E + R+++ Q E RW+
Sbjct: 1576 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ 1635
Query: 4859 TVCALSISKQTRLEAALRQAEEFHSVVHALLE-WLAEAEQTLRFHGVLPDDEDALRTLID 4917
L ++ RL + + S+ A E EAE+ R G + R L +
Sbjct: 1636 ----LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAE 1691
Query: 4918 QHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQ 4977
Q E ++L E A+ A + + + + + AR + A A Q +
Sbjct: 1692 QELEKQRQLAEGTAQQRLAAEQ-ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKR 1750
Query: 4978 QRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEM 5037
Q L + LA + A+ E+L A A + + ++K K+ + E + L EE
Sbjct: 1751 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL-------AEEA 1803
Query: 5038 TRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETKNP 5097
R + ++ K ++ A + ++ Q RA +R A L G T+++T+
Sbjct: 1804 ARLRALAEE-AKRQRQLAEEDAARQ---------RAEAERVLAEKLAAIGEATRLKTEAE 1853
Query: 5098 RVNLLVSKWQQVWLLALERRRKLNDALDRLEELREFANFDFDIWRKKYMRWMNHKKSRVM 5157
+AL+ + N+ L RL E F R++ K+ +
Sbjct: 1854 --------------IALKEKEAENERLRRLAEDEAFQ-------RRRLEEQAAQHKADIE 1892
Query: 5158 DFFRRIDKDQDGKITRQE-FIDGILSSKFPTSRLEMSAVADIFDRDGDGYIDYYEFVAAL 5216
+ ++ K D ++ RQ+ ++ L + E+ A+ F++ G + + +
Sbjct: 1893 ERLAQLRKASDSELERQKGLVEDTLRQRRQVEE-EILALKASFEKAAAGKAELELELGRI 1951
Query: 5217 HPNKDAYKPITDADKIEDEVTRQVAKCKCAKRFQVEQ 5253
N + + ++E RQ+A + +R + E+
Sbjct: 1952 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEE 1988
Score = 40.0 bits (92), Expect = 0.064
Identities = 84/510 (16%), Positives = 207/510 (40%), Gaps = 52/510 (10%)
Query: 1078 EKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQI-RTPLER 1136
+ E+ K++ ++ L+ + EQE + L + E + + L+ RL + +R
Sbjct: 2164 DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR 2223
Query: 1137 DDLHESVFRITEQ----EKLKKELER----------------LKDDLGTITNKCEEFFSQ 1176
+ E +F + Q KLK +E L+++ + EE
Sbjct: 2224 SQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARL 2283
Query: 1177 AAASSSVPTLRSELNVVLQNMNQVYSMSSTYI-DKLKTVNLVLKNTQAAEALVKLYETKL 1235
+ A+ LR + +++ Q +++ + +K++ V + AE L + E
Sbjct: 2284 SVAAQEAARLRQ---LAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ 2340
Query: 1236 CEEEAVIADKNNI-ENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERD 1294
+ + DK + + L + ++ ++ +RQ + E ++ K EM + +
Sbjct: 2341 EQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAE 2400
Query: 1295 LDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQR 1354
D +++A+++ E+ + ++ ++ + + L + I ++E +
Sbjct: 2401 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKE 2460
Query: 1355 KIQ-ENQPENSKTLATQLNQQKMLVSEIE-MKQSKMDEC------QKYAEQYSATVKD-Y 1405
K+Q E + K+ Q QQ+ L+ E + ++QS + E +++ EQ A ++ +
Sbjct: 2461 KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLF 2520
Query: 1406 ELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRY--------------TALV 1451
+ + + + + QQ+ ++++M+ ++ + R R L
Sbjct: 2521 QDEVAKAQQLREEQQR---QQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE 2577
Query: 1452 TLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPF 1511
Q + + +RL E+ + LEE+ + + ++E+ +KTL + A P
Sbjct: 2578 QQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPA 2637
Query: 1512 SKQKISSEEISTKKEQLSEALQTIQLFLAK 1541
++ + +++ ++ LQ + A+
Sbjct: 2638 AEAEPEHSFDGLRRKVSAQRLQEAGILSAE 2667
Score = 35.0 bits (79), Expect = 2.1
Identities = 73/348 (20%), Positives = 135/348 (38%), Gaps = 54/348 (15%)
Query: 4633 ISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLM-------EWLEESEKSLDSEL 4685
+ V+ W K+ ++ER + L +R + +KL E L +++ L S++
Sbjct: 364 LDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDV 423
Query: 4686 -------------EIANDPDKIKTQLAQ-HKEFQKSLGAKHSVYDTTNRTGRSLKEKTSL 4731
E+ D DK + + + Q +H + R L E+
Sbjct: 424 RLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVA 483
Query: 4732 --ADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEP 4789
+ NL+L ++ + + +SV+R+ +LE++ L LQ L+ W+ E
Sbjct: 484 IRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTL------RYLQDLLAWVE--EN 535
Query: 4790 QLAEDQPVHG-DIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSR----DDSS 4844
Q D G D+ V + +H+ + + + + ++ + +L +R D
Sbjct: 536 QHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLG 595
Query: 4845 WVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHAL---LEWLAEAEQTLRF 4901
+ +Q +L L+ SK A LR E HS V A L WL E E+
Sbjct: 596 RLDLQYAKL---------LNSSK-----ARLRSLESLHSFVAAATKELMWLNEKEEE-EV 640
Query: 4902 HGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHP 4949
D + + + M++LE K ++ + GD +L HP
Sbjct: 641 GFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHP 688
Score = 35.0 bits (79), Expect = 2.1
Identities = 22/51 (43%), Positives = 26/51 (50%)
Query: 5433 EDSGLITTAAARVRTQFADSKKTPSRPGSRAGSKAGSRASSRRGSDASDFD 5483
E +GL AA T+ S + S GS AGS+ GSR SR GS FD
Sbjct: 4457 EGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTGSRTGSRAGSRRGSFD 4507
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 861 bits (2224), Expect = 0.0
Identities = 637/2272 (28%), Positives = 1151/2272 (50%), Gaps = 200/2272 (8%)
Query: 641 EEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKI 700
E+ ++++QDLL WV+E Q ++D EWG DLPSVE+ L +H+ +H++IEEF + ++ A+
Sbjct: 486 EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS 545
Query: 701 SEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE 760
E Q++ + Y + L RL+ QYAKLLN+S+ + R L++LH+FV+ AT EL+WLNEKEE
Sbjct: 546 DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE 605
Query: 761 EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR 820
EEV +DWS+RNTN+ KK+ ++ LMREL+ KE+ IK +Q ++LL E+HPAR T+E+++
Sbjct: 606 EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 665
Query: 821 AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSI 880
AA+QTQWSW+LQLC C+E H+KEN AYF+FF+D +EA L+ L++A++RKYSCDRS+++
Sbjct: 666 AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATV 725
Query: 881 HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ 940
+LEDL+Q++ +EKE+L +YK ++ L +AK ++QLKPR+ P++ +P+ A+CDY+Q
Sbjct: 726 TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 785
Query: 941 IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ 1000
+E+T++K DEC L + + WKV+S +G+EA VPSVCF VPPPN+EA + R+E Q+Q
Sbjct: 786 VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ 845
Query: 1001 NVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFL 1060
++TLWH+ H++MKS+++W L ++ IR+ ++A+ +T+ P E +Q L +L+ ++ FL
Sbjct: 846 ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 905
Query: 1061 EDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLE 1120
DSQ++ F D E+E C +YQ+LL+S E+ QEES ISE+++IRL+LE
Sbjct: 906 RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE 965
Query: 1121 NCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAAS 1180
CE R + ++R PL+++ E RI EQ+K + E+E L + ++ + E+ + S
Sbjct: 966 ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1025
Query: 1181 SSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEA 1240
+ PTLRSEL + L + QV S+S+ Y++KLKT++LV++ TQ AE +++ +E +L E +A
Sbjct: 1026 PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1085
Query: 1241 VIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWH 1300
V A +E ++LK+ R++ + ++ F AL DEL+ A+ + + + + + ERD++ +
Sbjct: 1086 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1145
Query: 1301 KEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQ 1360
+E+ QL+ERWQ V Q D R R+LE +G+ L+YYR++ PL W+Q Q +IQ
Sbjct: 1146 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1205
Query: 1361 PENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQ 1420
+S+ + QL Q++ L+ EIE K++ECQ++A+QY +KDYELQ +TY+A ++
Sbjct: 1206 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLE-PV 1264
Query: 1421 KSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKK 1480
SP K+ ++QS ++ +IQE++DLRT Y+ L TL +QYIKF ++L+R+EEEE+ E+++
Sbjct: 1265 ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRA 1324
Query: 1481 E------HVEKAKELQKWVSNISKTLK-DAEKAGKPPFSKQKISSEEISTKKEQLSEALQ 1533
E VE A E Q+ ++ K AE+ K Q+ EE+ ++E +A Q
Sbjct: 1325 EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAK---ELQQRMQEEVVRREEAAVDAQQ 1381
Query: 1534 TIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKI-V 1592
++ ++++++ L++S +Q + ++ S +++EE+I V
Sbjct: 1382 ----------------QKRSIQEELQQLRQSSEAEIQAKARQAEAAERS-RLRIEEEIRV 1424
Query: 1593 AERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQ--EELQKDMQGS 1650
Q E E+ +G + G +A E +K Q+++ E L++ +Q
Sbjct: 1425 VRLQLEATERQRGGAE----------GELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1474
Query: 1651 AQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVT 1710
+Q + + +K E ++ +AL Q L E +++ E+ + Q++ E + V
Sbjct: 1475 SQRKRQAEVELASRVKAEAEAAREKQRAL--QALEELRLQAEEAERRLRQAEVERARQVQ 1532
Query: 1711 TAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDG 1770
A+ ET + +A +L+ + L ++ A + ++ E+ Q+ +
Sbjct: 1533 VAL--ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ--QQAEA 1588
Query: 1771 KSAIGE-EDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQ 1829
+ A E E E+ L+ + ++ E + QQ +A+ EK + A+
Sbjct: 1589 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK----------QKEEAE 1638
Query: 1830 VLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEF 1889
++G+ EE+ Q+ + E ++ + LAE + +L + ++EL + A+ +
Sbjct: 1639 REARRRGK---AEEQAVRQRELAEQELEKQRQLAEGTAQQRL--AAEQELIRLRAETEQG 1693
Query: 1890 EHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAK 1949
E Q E+EL L+ A ++++ ++ + ++ + S R E ++
Sbjct: 1694 EQQRQLLEEELARLQREA------AAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1747
Query: 1950 SCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCG 2009
S S++ +++ A R+L R R+L + ++ D + +A
Sbjct: 1748 STSEKSKQRLEAEAGR---FRELAEEAARLRALAEEAKRQRQLAEE--DAARQRAEAERV 1802
Query: 2010 LLAGLQAC-EATASKHLSEPIAVDPKNLQ----RQLEETKALQGQISSQQVAVEKLKKTA 2064
L L A EAT K +E IA+ K + R+L E +A Q + +Q A K
Sbjct: 1803 LAEKLAAIGEATRLKTEAE-IALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHK----- 1856
Query: 2065 EVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEML 2124
D L + L+ G ED + + E++ L+++ ++
Sbjct: 1857 ---ADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEI-------LALKASFEKAA 1906
Query: 2125 DWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDP 2184
G E L E G++ N+ +D + E + A RQ + A E+ ++ E
Sbjct: 1907 --AGKAELEL-ELGRIRSNA---EDTLRSKEQAELE-AARQRQLAAEEERRRREAE---- 1955
Query: 2185 STASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALT 2244
+ K L+A EA+ + K L ++E LK KVE L E+ + + Q
Sbjct: 1956 ------ERVQKSLAAE-EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ 2008
Query: 2245 EVDVPGKDVTE------LSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLE 2298
E E + Q QE + + L+ L + +++A V +
Sbjct: 2009 EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARV-Q 2067
Query: 2299 KTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGA 2358
++ +++E+ + K+ A Q + A K K +E ++ Q +
Sbjct: 2068 AEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQ 2127
Query: 2359 EDLGKS-LEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLN 2417
+ + +E KK E+ + ++++ ++ L T K + + L
Sbjct: 2128 KQAADAEMEKHKKFAEQTLRQKAQVEQ----ELTTLRLQLEETDHQKNL--LDEELQRLK 2181
Query: 2418 GEGTATNTEEFWANKGLTSIKKDMTDISH-----GYEDLGLLLKDKIAELNTKLSKLQKA 2472
E T + + L S++ M ++S E+ L+L+DK NT+ +
Sbjct: 2182 AEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKD---NTQ----RFL 2234
Query: 2473 QEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQE---L 2529
QEE+ M Q ++ + + Q+ A A + +Q E LK+ + VQE L
Sbjct: 2235 QEEAEKMKQVAEEAARLSVAAQEA-ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2293
Query: 2530 KDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQ-TVE 2588
K + ELL++ + + ++ +L D++Q ++ + FQ T+E
Sbjct: 2294 KAE-AELLQQQKELAQ---------------EQARRLQEDKEQMAQQLAEETQGFQRTLE 2337
Query: 2589 AQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILS 2648
A+ ++ L ++ + +++++ + E + + + E+ +
Sbjct: 2338 AERQRQL------------------EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE 2379
Query: 2649 RPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSD 2708
GE + ++ + Q + Q + + +AI + + + L+
Sbjct: 2380 EIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ------- 2432
Query: 2709 LDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCED----LSALVKEE 2764
+ KL + Q L+ Q ++Q EK + + E L L ++E
Sbjct: 2433 -EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDE 2491
Query: 2765 YLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQN 2824
KA+ R+ + + + +EQ+ + V ++ A H+ ++ R Q L ++++
Sbjct: 2492 VAKAQQLREEQ--QRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRR 2549
Query: 2825 KSHPISA--------KLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLL 2868
+ + A +L +LE + S+ +TA KT+ G + L
Sbjct: 2550 QQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDAL 2601
Score = 564 bits (1454), Expect = e-160
Identities = 270/452 (59%), Positives = 362/452 (80%), Gaps = 1/452 (0%)
Query: 69 IADERDKVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEVLSGDTLPREKGRM 128
+ DERD+VQKKTFTKW+N+HL+K ++H++DLYEDLRDGHNLISLLEVLSGD+LPREKGRM
Sbjct: 4 VPDERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRM 63
Query: 129 RFHRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIHVTGES 188
RFH+LQNVQIALDYL+ RQVKLVNIRNDDI DGNPKLTLGLIWTIILHFQISDI V+G+S
Sbjct: 64 RFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQS 123
Query: 189 EDMSAKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAVQSN 248
EDM+AKE+LLLW+Q+ EGY G+RC+NFT+ WRDG+LFNAIIH+++P LIDMN V Q+N
Sbjct: 124 EDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTN 183
Query: 249 LANLEHAFYVAEK-IGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAFPKVPEGGEGIGAN 307
L NL+ AF VAE+ +GV RLLDPEDVDV PDEKS+ITYVSSLYDA P+VP+ +G+ AN
Sbjct: 184 LENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRAN 243
Query: 308 DVEVKWIEYQNMVNYLIQWIRHHVTTMSERTFPNNPVELKALYNQYLQFKETEIPPKETE 367
+++++W EY+ +V L+QW+RHH ER FP++ E++ L++Q+L+FKE E+P KE +
Sbjct: 244 ELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEAD 303
Query: 368 KSKIKRLYKLLEIWIEFGRIKLLQGYHPNDIEKEWGKLIIAMLEREKALRPEVERLEMLQ 427
K++ K +Y+ LE ++ G++K+ GYHP D+EKEWGKL +A+LEREK LR E ERLE LQ
Sbjct: 304 KNRSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQ 363
Query: 428 QIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLLRQHVID 487
+I ++Q ++ +CE++L A LQSD + L +G Q E+ + + ++++R D
Sbjct: 364 RIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFND 423
Query: 488 VQILIDGKYYQADQLVQRVAKLRDEIMALRNE 519
VQ L DG++ Q +Q+ +RV +L + ++A+R E
Sbjct: 424 VQTLKDGRHPQGEQMYRRVYRLHERLVAIRTE 455
Score = 111 bits (277), Expect = 2e-23
Identities = 355/1874 (18%), Positives = 725/1874 (38%), Gaps = 306/1874 (16%)
Query: 2676 GQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQK 2735
G S + Q++ + Q +S + +L D+ +L + + H + E A++
Sbjct: 927 GSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARE 986
Query: 2736 MKQEI-QQEKKQIKVA---------QALCEDLSALVKEEYLKAELSRQLEGILKSFKDVE 2785
Q I +Q+K Q +V A E + AL + L +LE L + V
Sbjct: 987 CAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVR 1046
Query: 2786 QKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKD 2845
+ +++ L++ Q +A + KE Q + A L LE+ K
Sbjct: 1047 SLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQ----AVPATLPELEAT----KA 1098
Query: 2846 FSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQ----------------LNTIKTN 2889
K L AQ+ + T + L + +G+++ +LQ + +
Sbjct: 1099 SLKKLRAQAEAQQPTF---DALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLER 1155
Query: 2890 WDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFC--LDPAEGENS 2947
W Q R+ +L++ + Y+E + L W+ + E+I+ D
Sbjct: 1156 WQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQ 1215
Query: 2948 IAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSK 3007
+ + ++L +E+++H VE A ++ K
Sbjct: 1216 LRQEQALLEEIERHGEKVEECQRFAKQYINAI---------------------------K 1248
Query: 3008 KFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQA 3067
+ L+ +T K + S K ++Q E + I + + + + ++ T+ K +
Sbjct: 1249 DYELQLVTYKAQLEPVASPAKKPKVQSGSESV-IQEYVDLRTHYSELTTLTSQYIKFISE 1307
Query: 3068 LKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVET-IAQEHSTLSQQVDEKCSFLETKLQG 3126
+++ +RLA+ E + + L+ + +A+ H+ Q + + L+ ++Q
Sbjct: 1308 TLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ- 1366
Query: 3127 IGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKET-IKAFLKKLEALMASNDNA 3185
E+ + D + + + L++ E I+A ++ EA S
Sbjct: 1367 --------EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRI 1418
Query: 3186 NKTCKMM-LATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKL 3244
+ +++ L E T G + +L+AL +AR E+ E ++ +E +L
Sbjct: 1419 EEEIRVVRLQLEATERQRGGAEGELQAL-----------RARAEEAEAQKRQAQEEAERL 1467
Query: 3245 KEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLI 3304
+ + +ESQ E E ++ K E E + KQ+ + L + +
Sbjct: 1468 RR--------QVQDESQRKRQAEVELASRV--------KAEAEAAREKQRALQALEELRL 1511
Query: 3305 QSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVD 3364
Q+ + L + +RA Q+Q AL
Sbjct: 1512 QAEEAE-----------------RRLRQAEVERARQVQVAL------------------- 1535
Query: 3365 TEELVANQKPPSAEFKVVKAQIQEQKL-LQRLLDDRKSTVEVIKREGEKIATTAEPADKV 3423
Q+ AE + +A E+ L+R L + V ++ E E+ A A++
Sbjct: 1536 ----ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERA 1591
Query: 3424 KILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEP 3483
+ + L RW+ N+A Q E VAQQ + L + EK+ E
Sbjct: 1592 REEAEREL--ERWQLKANEALRLRLQAEE---VAQQ-----KSLAQ--AEAEKQKEEAER 1639
Query: 3484 IGTQASKLEEQIAQHKALEDDIINHNKHLHQAVS---IGQSLKVLSSREDKDMVQSKLDF 3540
+ K EEQ + + L + + + L + + + +++ R + + + +
Sbjct: 1640 EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL 1699
Query: 3541 SQVWYIEIQEKSHSRSELLQQALCN-AKIFGEDEVELMNWLN--EVHDKLSKLSVQDYST 3597
+ +Q ++ + ++ Q+ AK+ E EV L + E S+ S Q
Sbjct: 1700 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1759
Query: 3598 EG-----LWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKA 3652
E L ++ + LR L E+ ++Q ++ + +Q E ++ +KL AI
Sbjct: 1760 EAGRFRELAEEAARLRALAEEAKRQRQLAEE------DAARQRAEAE-RVLAEKLAAIG- 1811
Query: 3653 RYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQA 3712
+ T+L T+ L++ RL E+ ++E + ++ + E A
Sbjct: 1812 ---EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI----EERLA 1864
Query: 3713 QMRPKELKKEAKNNKALL-DSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTIT 3771
Q+R K E + K L+ D+L + E++ +A EK A E
Sbjct: 1865 QLR-KASDSELERQKGLVEDTLRQRRQVEEEILALKA--SFEKAAAGKAEL--------- 1912
Query: 3772 QKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTME 3831
E++ +RS D E + + ++ ++ + E+ + A+ +VQK+ E
Sbjct: 1913 ----ELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEE---ERRRREAEERVQKSLAAE 1965
Query: 3832 ---ILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLE- 3887
+ K ++++ + K+ EE + ++++ ++ + Q +++ LQ E
Sbjct: 1966 EEAARQRKAALEEVERLKAKV------EEARRLRERAEQESARQLQLAQEAAQKRLQAEE 2019
Query: 3888 RAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPH 3947
+A + Q E +EL L + QS++ QL A E R+ EE + R
Sbjct: 2020 KAHAFAVQQKE--QELQQTLQQEQSVLDQLRGEA---EAARRAAEEAEEARVQAEREAAQ 2074
Query: 3948 IDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQST----- 4002
+ + +L + + + + + AA+ L + +++ +RA A A+ Q
Sbjct: 2075 SRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAE 2134
Query: 4003 -QFHDK-----------IDQILESLE-RIVERLRQPPSISAEVEKIKEQISENK------ 4043
+ H K ++Q L +L ++ E Q + E++++K + +E
Sbjct: 2135 MEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQV 2194
Query: 4044 -----NVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHT 4098
+V V ME+L L ++ +I R DKD + + +Q++ ++M + E
Sbjct: 2195 EEELFSVRVQMEELSKLKARIEAENRALILR----DKDNTQRFLQEEAEKMKQVAEEAAR 2250
Query: 4099 L-VEEREAKLLDVMELAEKFWCDHMSLIVT-IKDTQDFIRDLEDPGIDPSVVKQQQEAAE 4156
L V +EA L +LAE+ +L +K+ +++ + +++QQ+E A+
Sbjct: 2251 LSVAAQEAARL--RQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ 2308
Query: 4157 TIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKL 4216
E+ LQE+ + ++ E + + E + +A + ++ ++
Sbjct: 2309 ---EQARRLQEDKE-------QMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKL-RV 2357
Query: 4217 EEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQI 4276
E +A + ++ Q + G KL + T+ Q +E I
Sbjct: 2358 AEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE-------------I 2404
Query: 4277 EMERLNHQAELLLKKVTE-ESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQ 4335
+ ++ +H AE L + + E E +K +Q E KL+ EE +Q +L AL Q
Sbjct: 2405 QRQQSDHDAERLREAIAELEREKEKLQQ---EAKLLQLKSEEMQTVQQEQLLQETQALQQ 2461
Query: 4336 FQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEI----ELAKHHVLQNDVLAHQSTVEAV 4391
++L+ + LL ++ + + +E E+AK L+ + Q +E
Sbjct: 2462 ---------SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQE 2512
Query: 4392 NKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIED 4451
+ L+ S EEA Q++ E +R Q L++ EQ+++Q + L + + + +
Sbjct: 2513 RQR---LVASM--EEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEE---NQRLRE 2564
Query: 4452 LQQWLTDTERHLLA 4465
Q L + R LA
Sbjct: 2565 QLQLLEEQHRAALA 2578
Score = 94.0 bits (232), Expect = 4e-18
Identities = 353/1847 (19%), Positives = 705/1847 (38%), Gaps = 283/1847 (15%)
Query: 3201 DLVGIKRDLEALSKQCNKLLDRAQ--AREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHE 3258
D + +R+ + S +LL + A+EE R + S+LK+ + L+ E
Sbjct: 918 DRLMAEREYGSCSHHYQQLLQSLEQGAQEES------RCQRCISELKDIRLQLEACETRT 971
Query: 3259 ESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAK--------- 3309
+ + ++ E + + I Q Q +V LG+G+ + +A+
Sbjct: 972 VHRLRLPLDKEPARECA--------QRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPE 1023
Query: 3310 -STSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEEL 3368
S + L +L+ + + + A +L+ L Q A E L + +E
Sbjct: 1024 PSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEA 1083
Query: 3369 VA------NQKPPSAEFKVVKAQIQ-EQKLLQRLLDDRKSTVEVIKREGEKIATTAEPAD 3421
A + A K ++AQ + +Q L D+ + EV +R ++ +
Sbjct: 1084 QAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVE 1143
Query: 3422 KVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNC 3481
+ + ++++ L RW+A+L + + R R+LE + + + E+ +PL WL +R
Sbjct: 1144 RWR--ERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQI 1201
Query: 3482 EPIGTQASK-LEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDF 3540
+ + S+ + EQ+ Q +AL ++I H + + + + + +V K
Sbjct: 1202 QAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQL 1261
Query: 3541 SQVWYIEIQEKSHSRSELLQQALCNAKI-FGEDEVELMNWLNEVHDKLSKLSVQDYSTEG 3599
V + K S SE + Q + + + E ++ + + L ++ ++ E
Sbjct: 1262 EPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE- 1320
Query: 3600 LWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITK 3659
+Q++E R R V+ AL +L + Q K +A + + +
Sbjct: 1321 --QQRAEERE-------RLAEVEAALEKQRQLAEAHA-------QAKAQAEREAKELQQR 1364
Query: 3660 LSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKEL 3719
+ +V + E A+ ++ S EEL E E+ + K +A A+ +
Sbjct: 1365 MQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQA------KARQAEAAERSRLRI 1418
Query: 3720 KKEAKNNKALLDSL-NEVSSALLELVPWRAR----EGLEKMVAEDNERYRLVSDTITQKV 3774
++E + + L++ + A EL RAR E ++ E+ ER R +Q+
Sbjct: 1419 EEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRK 1478
Query: 3775 EEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILR 3834
+ + + AE E ++ L +L ++RL+ ++ +L+ E+ R
Sbjct: 1479 RQAEV------ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR-----QAEVER 1527
Query: 3835 HKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVN 3894
+ V+ + +E E QS + +E+ QLER+
Sbjct: 1528 ARQ-----VQVALETAQRSAEAELQSKRASF--------------AEKTAQLERS----- 1563
Query: 3895 QFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKT 3954
L E ++QL E E QQQ E + RE E + +++
Sbjct: 1564 ------------LQEEHVAVAQLRE---EAERRAQQQAEAERARE---EAERELERWQLK 1605
Query: 3955 GPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILES 4014
+ L L Q+K +A Q KE+ ++ A +A Q+ + + +Q LE
Sbjct: 1606 ANEALRLRLQAEEVAQQKSLAQAEAEKQ-KEEAEREARRRGKAEEQAVRQRELAEQELEK 1664
Query: 4015 LERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTD 4074
++ E Q ++AE E I+ + + E+ + L E R + A +
Sbjct: 1665 QRQLAEGTAQ-QRLAAEQELIRLRAETEQG-----EQQRQLLEEELARLQREAAAATQKR 1718
Query: 4075 KDISAKAVQDKLDQMVFIWENIHTLVEER----------EAKLLDVMELAEKFWCDHMSL 4124
+++ A+ + + + V + E R EA+ ELAE+ +
Sbjct: 1719 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE-----AAR 1773
Query: 4125 IVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQE------ELDIVI---NL 4175
+ + + R L + +Q+ EA + E++ + E E +I +
Sbjct: 1774 LRALAEEAKRQRQL----AEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEA 1829
Query: 4176 GSELIAACGEPDKPIVKKSIDE--------LNSAWDSLNKAWKDRIDK----LEEAMQAA 4223
+E + E D+ ++ ++E + L KA +++ +E+ ++
Sbjct: 1830 ENERLRRLAE-DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQR 1888
Query: 4224 VQYQDGLQAV-FDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQ---IEME 4279
Q ++ + A+ + A GK +G + + +Q + EA +Q+ E E
Sbjct: 1889 RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE 1948
Query: 4280 RLNHQAELLLKK--VTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQ 4337
R +AE ++K EE + L E++ + +EE R+ + + L Q
Sbjct: 1949 RRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ 2008
Query: 4338 HALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAH-QSTVEAVNKAGN 4396
A + L +QK E EL + + VL + EA +A
Sbjct: 2009 EAAQKRLQAEEKAHAFAVQQK---------EQELQQTLQQEQSVLDQLRGEAEAARRAAE 2059
Query: 4397 DLIES--SAGEEASNLQNKLEVLNQRWQNVLEKTEQ-----------RKQQLDGALRQAK 4443
+ E+ A EA+ + ++E + Q+ E+ + RK+ A R+A+
Sbjct: 2060 EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQ 2119
Query: 4444 GFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEET--YKSLM 4501
+ Q + E+H ++ +T +++ V E+ EET K+L+
Sbjct: 2120 AEQAALRQKQAADAEMEKHKKFAE------QTLRQKAQVEQELTTLRLQLEETDHQKNLL 2173
Query: 4502 QKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNE---RKTKLE-EALNLAMEFHNS 4557
+ Q L K+ T + + ++E+ SV ++ E K ++E E L + ++
Sbjct: 2174 DEELQRL----KAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDN 2229
Query: 4558 LQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLK 4617
Q F+ +AE+ VA + L + + A E + + + E K
Sbjct: 2230 TQRFLQ--EEAEKMKQVAEEAAR-LSVAAQEAARLRQLAEEDLAQQRALAE--------K 2278
Query: 4618 YFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSL-DDARKRAKQFHEAWSKLMEWLEE 4676
+K V L + ++ + E+ R L +D + A+Q E LE
Sbjct: 2279 MLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA 2338
Query: 4677 SEKSLDSELEIANDPDKIKTQLAQ--------HKEFQKSLGAKHSVYDTTNRTGRSLKEK 4728
+ +LE++ + +++K ++A+ ++ Q+ + + +RT + +EK
Sbjct: 2339 ERQ---RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEK 2395
Query: 4729 TSLAD-----------DNLKLDDMLSELRDKWDTICG-------KSVERQNKLEEALLFS 4770
+L D +L + ++EL + + + KS E Q +E LL
Sbjct: 2396 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLL-- 2453
Query: 4771 GQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKR 4830
Q T ALQ +L + L ++ + + + L + A ++L + Q
Sbjct: 2454 -QETQALQQ--SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2510
Query: 4831 SARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLE 4890
R+ + S +++ + + +E R + + +LE RQ EE
Sbjct: 2511 QERQRLVASMEEARRRQHEAEEGVRRKQ-------EELQQLEQQRRQQEEL--------- 2554
Query: 4891 WLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKAT 4937
LAE Q LR + L+ L +QH+ + EE A AT
Sbjct: 2555 -LAEENQRLR---------EQLQLLEEQHRAALAHSEEVTASQVAAT 2591
Score = 85.1 bits (209), Expect = 2e-15
Identities = 295/1541 (19%), Positives = 608/1541 (39%), Gaps = 226/1541 (14%)
Query: 3708 EASQAQMRPKELKKEAKNNKALLDSLN-------EVSSAL--------LELVPWRAREGL 3752
EA++A + K+L+ +A+ + D+L EV L +E+ WR R
Sbjct: 1094 EATKASL--KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRER--- 1148
Query: 3753 EKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIR 3812
VA+ ER++ V + E++ + + + ++AD +W+ + ++ + +
Sbjct: 1149 ---VAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1205
Query: 3813 LEQDQT-SAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQ--SMKKKLDKVL 3869
L Q QL+ ++ EI RH + +++ + + + A + E Q + K +L+ V
Sbjct: 1206 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA 1265
Query: 3870 KNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQ 3929
+ + QS + Y +L +E ++ SQ ETLR+
Sbjct: 1266 SP------------AKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIK--FISETLRR 1311
Query: 3930 QQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKK 3989
+EE R + AE + + ++ + +L+ + + A L +++E+V +
Sbjct: 1312 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1371
Query: 3990 RAVALDEAISQSTQFHDKIDQILESLERIVE-RLRQPPSISAEVEKIKEQISENKNVSVD 4048
R A +A Q +++ Q+ +S E ++ + RQ + +I+E+I
Sbjct: 1372 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR-------- 1423
Query: 4049 MEKLQPLYETLKQRG----EEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEERE 4104
+ +LQ L T +QRG E R+ + + + Q++ +++ + +E +
Sbjct: 1424 VVRLQ-LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLR------RQVQDESQ 1476
Query: 4105 AKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIRE-EID 4163
K +ELA + + + ++ Q ++ LE+ + Q +EA +R+ E++
Sbjct: 1477 RKRQAEVELASRVKAEAEAA----REKQRALQALEELRL------QAEEAERRLRQAEVE 1526
Query: 4164 GLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWD-SLNKAWKDRIDKLEEAMQA 4222
++ + + E E + + S E + + SL + EEA +
Sbjct: 1527 RARQ-----VQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERR 1581
Query: 4223 AVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLN 4282
A Q + +A + A +L + ++ Q EE+ Q KS A Q E E+
Sbjct: 1582 AQQQAEAERAREE----AERELERWQLKANEALRLRLQAEEVAQQKSLA---QAEAEKQK 1634
Query: 4283 HQAELLLKKVTEESDKHTVQDPLMELKLIWD-SLEERIINRQHKLEGALLALG------- 4334
+AE ++ + ++ Q L E +L L E ++ E L+ L
Sbjct: 1635 EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1694
Query: 4335 QFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKA 4394
Q + L+E LA L ++++ + +E ELAK +LA ++ E +++
Sbjct: 1695 QQRQLLEEELARLQREAAAATQKR------QELEAELAKVRAEMEVLLASKARAEEESRS 1748
Query: 4395 GNDL----IESSAG------EEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKG 4444
++ +E+ AG EEA+ L+ E ++ Q E +++ + + L +
Sbjct: 1749 TSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLA 1808
Query: 4445 FHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKG 4504
GE L+ TE + + E E+L + AF+ + ++ K
Sbjct: 1809 AIGEATRLK-----TEAEIALKEK-----EAENERLR-RLAEDEAFQRRRLEEQAAQHKA 1857
Query: 4505 --QQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFI 4562
++ LA+ K++++ +++ VE L +R+ EE L L F +
Sbjct: 1858 DIEERLAQLRKASDSELERQKG-------LVEDTLRQRRQVEEEILALKASFEKAAAG-- 1908
Query: 4563 NWLTQAEQTLNVASRPSLILDTV-------LFQIDEHKVFANEVNSHREQIIELDKTGTH 4615
+AE L + S DT+ L + ++ A E RE + K+
Sbjct: 1909 ----KAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAA 1964
Query: 4616 LKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLE 4675
+ ++++ L + V+RL + R+RA+Q E+ +L E
Sbjct: 1965 EEEAARQRKAAL-------------EEVERLKAKVEEARRLRERAEQ--ESARQLQLAQE 2009
Query: 4676 ESEKSLDSELEIANDPDKIKTQLAQHKE--FQKSLGAKHSVYDTTNRTGRSLKEKTSLAD 4733
++K L +E +K Q KE Q++L + SV D + + A+
Sbjct: 2010 AAQKRLQAE-------EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE 2062
Query: 4734 D-NLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLA 4792
+ ++ + ++ R + VE +L+++ Q QA + L + Q A
Sbjct: 2063 EARVQAEREAAQSR--------RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2114
Query: 4793 E-----DQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVK 4847
+Q ++ HK F ++ ++ + V+ + R +E + + +
Sbjct: 2115 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2174
Query: 4848 VQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPD 4907
++Q L + L + Q EE L+ EAE ++
Sbjct: 2175 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSK-----LKARIEAEN----RALILR 2225
Query: 4908 DEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFE 4967
D+D + + + E MK++ E+ A L+ A + + D + RA E
Sbjct: 2226 DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED--------LAQQRALAE 2277
Query: 4968 EVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALI 5027
++L K+ Q + A L A+ ELL+ Q L + +++ Q EE +
Sbjct: 2278 KML---KEKMQAVQEA-TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGF- 2332
Query: 5028 AEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSG 5087
Q +E ++Q ++ + K R A+ S Q+ + A R R A +
Sbjct: 2333 ---QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA----EEDAQRFRKQAEEIGEKL 2385
Query: 5088 SQTQIETKNPRVNLLVSKWQQVWLLALERRR------KLNDALDRLEELREFANFDFDIW 5141
+T++ T+ K V L ++R++ +L +A+ LE +E + +
Sbjct: 2386 HRTELATQ--------EKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL 2437
Query: 5142 RKKYMRWMNHKKSRVMDFFRRIDK----DQDGKITRQEFID 5178
+ K ++ +++ + + + ++D + R+ FI+
Sbjct: 2438 QLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE 2478
Score = 78.6 bits (192), Expect = 2e-13
Identities = 352/1885 (18%), Positives = 731/1885 (38%), Gaps = 251/1885 (13%)
Query: 3336 QRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRL 3395
QR +L+++ L L+ LL+W+ + + V + + V+AQ+ + L +
Sbjct: 480 QRRPELEDSTLRY------LQDLLAWVEENQHRVDGAEW-GVDLPSVEAQLGSHRGLHQS 532
Query: 3396 LDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGI-S 3454
+++ ++ +E + + +++ PA + L LD ++ LLN ++ R R LE + S
Sbjct: 533 IEEFRAKIERARSDEGQLS----PATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHS 588
Query: 3455 VVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQ 3514
VA E + WL E+ V + + + + + + AL ++ K + +
Sbjct: 589 FVAAATKELM-----WLNEKEEEEVGFD-WSDRNTNMTAKKESYSALMRELELKEKKIKE 642
Query: 3515 AVSIGQSL--KVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGED 3572
+ G L + +R + Q+ L W +LQ C
Sbjct: 643 LQNAGDRLLREDHPARPTVESFQAALQTQWSW-------------MLQLCCC-------- 681
Query: 3573 EVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQ-ALLNGLEL 3631
E H K + Q +S + + + +L+ LQE L RK + D+ A + LE
Sbjct: 682 --------IEAHLKENAAYFQFFS--DVREAEGQLQKLQE-ALRRKYSCDRSATVTRLED 730
Query: 3632 LKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDK 3691
L Q DE +++L K + +AK + +QL R H H
Sbjct: 731 LLQDAQDE----KEQLNEYKGHL-------SGLAKRAKAVVQLKPR-HPAHPMRGRLPLL 778
Query: 3692 VEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVS-SALLELVPWRARE 3750
+ E V KG+E + + K L S +E + ++ LVP +E
Sbjct: 779 AVCDYKQVEVTVHKGDECQLVG------PAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQE 832
Query: 3751 GLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGD 3810
E + + + LV T+ ++ ++L Q + SW T + L
Sbjct: 833 AQEAVTRLEAQHQALV--TLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKP--- 887
Query: 3811 IRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLK 3870
EQ Q L+ L ++ + D +G E++ +++
Sbjct: 888 --EEQRQALHSLE---------LHYQAFLRDSQDAG-----GFGPEDRLMAEREYGSCSH 931
Query: 3871 NYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQ 3930
+Y + Q + + R Q +++ + +L T T + +L P
Sbjct: 932 HYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRT---VHRLRLPL--------D 980
Query: 3931 QEEHRQLRELIAEHKPHIDKMNKTGPQLLELS--PGEGFSIQEKYVAADTLYSQIKEDVK 3988
+E R+ + IAE + ++ G + LS + ++ E AA TL S+++ +
Sbjct: 981 KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLG 1040
Query: 3989 KRAVALDEAISQSTQFHDKIDQIL----------ESLERIVERLRQPPSISAEVEKIKEQ 4038
K L++ S S + +K+ I E L E+L++ ++ A + +++
Sbjct: 1041 K----LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEAT 1096
Query: 4039 ISENKNVSVDMEKLQPLYETLKQR-------GEEMIARSGGTDKDISAKAVQDKLDQMVF 4091
+ K + E QP ++ L+ GE + R G ++D+ + ++++ Q++
Sbjct: 1097 KASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHG--ERDVEVERWRERVAQLLE 1154
Query: 4092 IWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLED-PGIDPSVVKQ 4150
W+ + + R+ +L + + L ++D + ++ P D V++
Sbjct: 1155 RWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVRE 1214
Query: 4151 QQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIV--KKSID---------ELN 4199
Q + + EEI+ E+++ + I A + + +V K ++ ++
Sbjct: 1215 QLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQ 1274
Query: 4200 SAWDSLNKAWKDRIDKLEEAMQAAVQY----QDGLQAVFDWVDIAGGKLAS----MSPIG 4251
S +S+ + + D E QY + L+ + + +A + A ++ +
Sbjct: 1275 SGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVE 1334
Query: 4252 TDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKK---VTEESDKHTVQDPLMEL 4308
LE +Q E Q K++A ++ E+++ Q E++ ++ V + K ++Q+ L +L
Sbjct: 1335 AALEKQRQLAEAHAQAKAQAEREAKELQQ-RMQEEVVRREEAAVDAQQQKRSIQEELQQL 1393
Query: 4309 KLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIE 4368
+ S E I + + E A + + + + + L TE + GG ++
Sbjct: 1394 R---QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATE------RQRGGAEGELQ 1444
Query: 4369 IELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEE---ASNLQNKLEVLNQRWQNVL 4425
A+ + Q E + + D + E AS ++ + E ++ Q L
Sbjct: 1445 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREK-QRAL 1503
Query: 4426 EKTEQRKQQLDGALRQAKGFHGEIE---DLQQWLTDTERHL---LASKPLGGLPETAKEQ 4479
+ E+ + Q + A R+ + E+E +Q L +R L SK +TA+ +
Sbjct: 1504 QALEELRLQAEEAERRLR--QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE 1561
Query: 4480 LNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNE 4539
++ E A + +EE + Q+ + AR E E +L
Sbjct: 1562 RSLQEEHVAVAQLREEAERRAQQQAEAERAR--------------------EEAERELER 1601
Query: 4540 RKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEV 4599
+ K EAL L ++ Q +AE+ A R + Q + A +
Sbjct: 1602 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1661
Query: 4600 NSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKR 4659
+ Q+ E GT + + +Q+++ ++ + + + + + L R A ++
Sbjct: 1662 LEKQRQLAE----GTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK 1717
Query: 4660 AKQFHEAWSKL---MEWLEESEKSLDSELEIANDPDK--IKTQLAQHKEFQKSLGAKHSV 4714
++ +K+ ME L S+ + E ++ K ++ + + +E + ++
Sbjct: 1718 RQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRAL 1777
Query: 4715 YDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFT 4774
+ R R L E+ + A + + +L+E G++ + + E AL
Sbjct: 1778 AEEAKRQ-RQLAEEDA-ARQRAEAERVLAEKL----AAIGEATRLKTEAEIALKEKEAEN 1831
Query: 4775 DALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARE 4834
+ L+ L + + + E+Q D+ L KA EL ++ V+ R R+
Sbjct: 1832 ERLRRLAE-DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQ 1890
Query: 4835 L------IEGSRDDSSWVKVQMQ-ELS-TRWETVCALSISKQTRLEAALRQ---AEE--- 4880
+ ++ S + ++ K +++ EL R L +Q LEAA ++ AEE
Sbjct: 1891 VEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERR 1950
Query: 4881 FHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRA-ELNKATTM 4939
+ + LA E+ R ++ + L+ +++ + ++ E++ A +L A
Sbjct: 1951 RREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA 2010
Query: 4940 GDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQ----QRLASALAGLIAKQELLE 4995
L K ++ + +E+ +Q Q Q A A A +E E
Sbjct: 2011 AQKRLQ-------AEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2063
Query: 4996 A-LLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRR 5054
A + A + A++ ++ E + Q EE A+ Q E++ RK+ + + +R
Sbjct: 2064 ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL-RKEAEQEAA----RRA 2118
Query: 5055 AADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGS--------QTQIETKNPRVNLLVSKW 5106
A+ ++L+ D K+F +L + Q+E + + NLL +
Sbjct: 2119 QAEQAALRQK-QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEEL 2177
Query: 5107 QQVWLLALERRRKLNDALDRLEELR 5131
Q++ A E R+ + + L +R
Sbjct: 2178 QRLKAEATEAARQRSQVEEELFSVR 2202
Score = 69.3 bits (168), Expect = 1e-10
Identities = 208/1057 (19%), Positives = 422/1057 (39%), Gaps = 142/1057 (13%)
Query: 4258 KQQIEELKQFKSEAYQQQIEME-------RLNHQAELLLKKVTEESDKHTVQDPLMELKL 4310
K+ E Q +E + Q E+E RL+ +AE +L T++ EL+L
Sbjct: 981 KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRS---ELEL 1037
Query: 4311 IWDSLEE-RIINRQH--KLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAI 4367
LE+ R ++ + KL+ L + Q A + L A E L E + V +
Sbjct: 1038 TLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAH----EEQLKEAQAVPATLPEL 1093
Query: 4368 EIELAKHHVLQNDVLAHQSTVEAVN------KAGNDLIESSAGE---EASNLQNKLEVLN 4418
E A L+ A Q T +A+ + + ++ GE E + ++ L
Sbjct: 1094 EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLL 1153
Query: 4419 QRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTER--HLLASKPLGGLPETA 4476
+RWQ VL +T+ R+++L+ RQ + + + L WL D R + + PL +
Sbjct: 1154 ERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLAD-SQAV 1212
Query: 4477 KEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETK 4536
+EQL +E+ +++ + + C + A+ Q IN +K+ E +
Sbjct: 1213 REQLR-----------QEQALLEEIERHGEKVEECQRFAK----QYINAIKD----YELQ 1253
Query: 4537 LNERKTKLEEALNLAME------FHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQID 4590
L K +LE + A + + +Q++++ T + + S+ + L +++
Sbjct: 1254 LVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRME 1313
Query: 4591 EHKVFAN-----------EVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRW 4639
E + A EV + E+ +L + K ++++ L + + V R
Sbjct: 1314 EEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRRE 1373
Query: 4640 EKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLA 4699
E V ++ RS+ + ++ +Q EA ++ ++E + S L I + ++ QL
Sbjct: 1374 EAAVDAQQQK-RSIQEELQQLRQSSEA--EIQAKARQAEAAERSRLRIEEEIRVVRLQL- 1429
Query: 4700 QHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVER 4759
+ E Q+ GA+ + R + +K ++ + + +++D+ VE
Sbjct: 1430 EATERQRG-GAEGELQALRARAEEAEAQKRQAQEE---AERLRRQVQDESQRKRQAEVEL 1485
Query: 4760 QNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDID----LVMNLIDNHKAFQ 4815
++++ + + ALQAL + R++ + AE + +++ + + L ++ +
Sbjct: 1486 ASRVKAEAEAAREKQRALQALEE--LRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1543
Query: 4816 KELGKRTSS----VQALKRSARE---LIEGSRDDSSWVKVQMQELS----------TRWE 4858
EL + +S L+RS +E + R+++ Q E RW+
Sbjct: 1544 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ 1603
Query: 4859 TVCALSISKQTRLEAALRQAEEFHSVVHALLE-WLAEAEQTLRFHGVLPDDEDALRTLID 4917
L ++ RL + + S+ A E EAE+ R G + R L +
Sbjct: 1604 ----LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAE 1659
Query: 4918 QHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQ 4977
Q E ++L E A+ A + + + + + AR + A A Q +
Sbjct: 1660 QELEKQRQLAEGTAQQRLAAEQ-ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKR 1718
Query: 4978 QRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEM 5037
Q L + LA + A+ E+L A A + + ++K K+ + E + L EE
Sbjct: 1719 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL-------AEEA 1771
Query: 5038 TRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETKNP 5097
R + ++ K ++ A + ++ Q RA +R A L G T+++T+
Sbjct: 1772 ARLRALAEE-AKRQRQLAEEDAARQ---------RAEAERVLAEKLAAIGEATRLKTEAE 1821
Query: 5098 RVNLLVSKWQQVWLLALERRRKLNDALDRLEELREFANFDFDIWRKKYMRWMNHKKSRVM 5157
+AL+ + N+ L RL E F R++ K+ +
Sbjct: 1822 --------------IALKEKEAENERLRRLAEDEAFQ-------RRRLEEQAAQHKADIE 1860
Query: 5158 DFFRRIDKDQDGKITRQE-FIDGILSSKFPTSRLEMSAVADIFDRDGDGYIDYYEFVAAL 5216
+ ++ K D ++ RQ+ ++ L + E+ A+ F++ G + + +
Sbjct: 1861 ERLAQLRKASDSELERQKGLVEDTLRQRRQVEE-EILALKASFEKAAAGKAELELELGRI 1919
Query: 5217 HPNKDAYKPITDADKIEDEVTRQVAKCKCAKRFQVEQ 5253
N + + ++E RQ+A + +R + E+
Sbjct: 1920 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEE 1956
Score = 40.0 bits (92), Expect = 0.064
Identities = 84/510 (16%), Positives = 207/510 (40%), Gaps = 52/510 (10%)
Query: 1078 EKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQI-RTPLER 1136
+ E+ K++ ++ L+ + EQE + L + E + + L+ RL + +R
Sbjct: 2132 DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR 2191
Query: 1137 DDLHESVFRITEQ----EKLKKELER----------------LKDDLGTITNKCEEFFSQ 1176
+ E +F + Q KLK +E L+++ + EE
Sbjct: 2192 SQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARL 2251
Query: 1177 AAASSSVPTLRSELNVVLQNMNQVYSMSSTYI-DKLKTVNLVLKNTQAAEALVKLYETKL 1235
+ A+ LR + +++ Q +++ + +K++ V + AE L + E
Sbjct: 2252 SVAAQEAARLRQ---LAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ 2308
Query: 1236 CEEEAVIADKNNI-ENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERD 1294
+ + DK + + L + ++ ++ +RQ + E ++ K EM + +
Sbjct: 2309 EQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAE 2368
Query: 1295 LDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQR 1354
D +++A+++ E+ + ++ ++ + + L + I ++E +
Sbjct: 2369 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKE 2428
Query: 1355 KIQ-ENQPENSKTLATQLNQQKMLVSEIE-MKQSKMDEC------QKYAEQYSATVKD-Y 1405
K+Q E + K+ Q QQ+ L+ E + ++QS + E +++ EQ A ++ +
Sbjct: 2429 KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLF 2488
Query: 1406 ELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRY--------------TALV 1451
+ + + + + QQ+ ++++M+ ++ + R R L
Sbjct: 2489 QDEVAKAQQLREEQQR---QQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE 2545
Query: 1452 TLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPF 1511
Q + + +RL E+ + LEE+ + + ++E+ +KTL + A P
Sbjct: 2546 QQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPA 2605
Query: 1512 SKQKISSEEISTKKEQLSEALQTIQLFLAK 1541
++ + +++ ++ LQ + A+
Sbjct: 2606 AEAEPEHSFDGLRRKVSAQRLQEAGILSAE 2635
Score = 35.0 bits (79), Expect = 2.1
Identities = 73/348 (20%), Positives = 135/348 (38%), Gaps = 54/348 (15%)
Query: 4633 ISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLM-------EWLEESEKSLDSEL 4685
+ V+ W K+ ++ER + L +R + +KL E L +++ L S++
Sbjct: 332 LDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDV 391
Query: 4686 -------------EIANDPDKIKTQLAQ-HKEFQKSLGAKHSVYDTTNRTGRSLKEKTSL 4731
E+ D DK + + + Q +H + R L E+
Sbjct: 392 RLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVA 451
Query: 4732 --ADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEP 4789
+ NL+L ++ + + +SV+R+ +LE++ L LQ L+ W+ E
Sbjct: 452 IRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTL------RYLQDLLAWVE--EN 503
Query: 4790 QLAEDQPVHG-DIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSR----DDSS 4844
Q D G D+ V + +H+ + + + + ++ + +L +R D
Sbjct: 504 QHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLG 563
Query: 4845 WVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHAL---LEWLAEAEQTLRF 4901
+ +Q +L L+ SK A LR E HS V A L WL E E+
Sbjct: 564 RLDLQYAKL---------LNSSK-----ARLRSLESLHSFVAAATKELMWLNEKEEE-EV 608
Query: 4902 HGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHP 4949
D + + + M++LE K ++ + GD +L HP
Sbjct: 609 GFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHP 656
Score = 35.0 bits (79), Expect = 2.1
Identities = 22/51 (43%), Positives = 26/51 (50%)
Query: 5433 EDSGLITTAAARVRTQFADSKKTPSRPGSRAGSKAGSRASSRRGSDASDFD 5483
E +GL AA T+ S + S GS AGS+ GSR SR GS FD
Sbjct: 4425 EGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTGSRTGSRAGSRRGSFD 4475
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 861 bits (2224), Expect = 0.0
Identities = 637/2272 (28%), Positives = 1151/2272 (50%), Gaps = 200/2272 (8%)
Query: 641 EEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKI 700
E+ ++++QDLL WV+E Q ++D EWG DLPSVE+ L +H+ +H++IEEF + ++ A+
Sbjct: 655 EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS 714
Query: 701 SEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE 760
E Q++ + Y + L RL+ QYAKLLN+S+ + R L++LH+FV+ AT EL+WLNEKEE
Sbjct: 715 DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE 774
Query: 761 EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR 820
EEV +DWS+RNTN+ KK+ ++ LMREL+ KE+ IK +Q ++LL E+HPAR T+E+++
Sbjct: 775 EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 834
Query: 821 AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSI 880
AA+QTQWSW+LQLC C+E H+KEN AYF+FF+D +EA L+ L++A++RKYSCDRS+++
Sbjct: 835 AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATV 894
Query: 881 HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ 940
+LEDL+Q++ +EKE+L +YK ++ L +AK ++QLKPR+ P++ +P+ A+CDY+Q
Sbjct: 895 TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 954
Query: 941 IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ 1000
+E+T++K DEC L + + WKV+S +G+EA VPSVCF VPPPN+EA + R+E Q+Q
Sbjct: 955 VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ 1014
Query: 1001 NVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFL 1060
++TLWH+ H++MKS+++W L ++ IR+ ++A+ +T+ P E +Q L +L+ ++ FL
Sbjct: 1015 ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 1074
Query: 1061 EDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLE 1120
DSQ++ F D E+E C +YQ+LL+S E+ QEES ISE+++IRL+LE
Sbjct: 1075 RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE 1134
Query: 1121 NCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAAS 1180
CE R + ++R PL+++ E RI EQ+K + E+E L + ++ + E+ + S
Sbjct: 1135 ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1194
Query: 1181 SSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEA 1240
+ PTLRSEL + L + QV S+S+ Y++KLKT++LV++ TQ AE +++ +E +L E +A
Sbjct: 1195 PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1254
Query: 1241 VIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWH 1300
V A +E ++LK+ R++ + ++ F AL DEL+ A+ + + + + + ERD++ +
Sbjct: 1255 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1314
Query: 1301 KEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQ 1360
+E+ QL+ERWQ V Q D R R+LE +G+ L+YYR++ PL W+Q Q +IQ
Sbjct: 1315 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1374
Query: 1361 PENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQ 1420
+S+ + QL Q++ L+ EIE K++ECQ++A+QY +KDYELQ +TY+A ++
Sbjct: 1375 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLE-PV 1433
Query: 1421 KSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKK 1480
SP K+ ++QS ++ +IQE++DLRT Y+ L TL +QYIKF ++L+R+EEEE+ E+++
Sbjct: 1434 ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRA 1493
Query: 1481 E------HVEKAKELQKWVSNISKTLK-DAEKAGKPPFSKQKISSEEISTKKEQLSEALQ 1533
E VE A E Q+ ++ K AE+ K Q+ EE+ ++E +A Q
Sbjct: 1494 EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAK---ELQQRMQEEVVRREEAAVDAQQ 1550
Query: 1534 TIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKI-V 1592
++ ++++++ L++S +Q + ++ S +++EE+I V
Sbjct: 1551 ----------------QKRSIQEELQQLRQSSEAEIQAKARQAEAAERS-RLRIEEEIRV 1593
Query: 1593 AERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQ--EELQKDMQGS 1650
Q E E+ +G + G +A E +K Q+++ E L++ +Q
Sbjct: 1594 VRLQLEATERQRGGAE----------GELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1643
Query: 1651 AQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVT 1710
+Q + + +K E ++ +AL Q L E +++ E+ + Q++ E + V
Sbjct: 1644 SQRKRQAEVELASRVKAEAEAAREKQRAL--QALEELRLQAEEAERRLRQAEVERARQVQ 1701
Query: 1711 TAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDG 1770
A+ ET + +A +L+ + L ++ A + ++ E+ Q+ +
Sbjct: 1702 VAL--ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ--QQAEA 1757
Query: 1771 KSAIGE-EDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQ 1829
+ A E E E+ L+ + ++ E + QQ +A+ EK + A+
Sbjct: 1758 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK----------QKEEAE 1807
Query: 1830 VLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEF 1889
++G+ EE+ Q+ + E ++ + LAE + +L + ++EL + A+ +
Sbjct: 1808 REARRRGK---AEEQAVRQRELAEQELEKQRQLAEGTAQQRL--AAEQELIRLRAETEQG 1862
Query: 1890 EHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAK 1949
E Q E+EL L+ A ++++ ++ + ++ + S R E ++
Sbjct: 1863 EQQRQLLEEELARLQREA------AAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1916
Query: 1950 SCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCG 2009
S S++ +++ A R+L R R+L + ++ D + +A
Sbjct: 1917 STSEKSKQRLEAEAGR---FRELAEEAARLRALAEEAKRQRQLAEE--DAARQRAEAERV 1971
Query: 2010 LLAGLQAC-EATASKHLSEPIAVDPKNLQ----RQLEETKALQGQISSQQVAVEKLKKTA 2064
L L A EAT K +E IA+ K + R+L E +A Q + +Q A K
Sbjct: 1972 LAEKLAAIGEATRLKTEAE-IALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHK----- 2025
Query: 2065 EVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEML 2124
D L + L+ G ED + + E++ L+++ ++
Sbjct: 2026 ---ADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEI-------LALKASFEKAA 2075
Query: 2125 DWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDP 2184
G E L E G++ N+ +D + E + A RQ + A E+ ++ E
Sbjct: 2076 --AGKAELEL-ELGRIRSNA---EDTLRSKEQAELE-AARQRQLAAEEERRRREAE---- 2124
Query: 2185 STASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALT 2244
+ K L+A EA+ + K L ++E LK KVE L E+ + + Q
Sbjct: 2125 ------ERVQKSLAAE-EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ 2177
Query: 2245 EVDVPGKDVTE------LSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLE 2298
E E + Q QE + + L+ L + +++A V +
Sbjct: 2178 EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARV-Q 2236
Query: 2299 KTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGA 2358
++ +++E+ + K+ A Q + A K K +E ++ Q +
Sbjct: 2237 AEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQ 2296
Query: 2359 EDLGKS-LEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLN 2417
+ + +E KK E+ + ++++ ++ L T K + + L
Sbjct: 2297 KQAADAEMEKHKKFAEQTLRQKAQVEQ----ELTTLRLQLEETDHQKNL--LDEELQRLK 2350
Query: 2418 GEGTATNTEEFWANKGLTSIKKDMTDISH-----GYEDLGLLLKDKIAELNTKLSKLQKA 2472
E T + + L S++ M ++S E+ L+L+DK NT+ +
Sbjct: 2351 AEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKD---NTQ----RFL 2403
Query: 2473 QEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQE---L 2529
QEE+ M Q ++ + + Q+ A A + +Q E LK+ + VQE L
Sbjct: 2404 QEEAEKMKQVAEEAARLSVAAQEA-ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2462
Query: 2530 KDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQ-TVE 2588
K + ELL++ + + ++ +L D++Q ++ + FQ T+E
Sbjct: 2463 KAE-AELLQQQKELAQ---------------EQARRLQEDKEQMAQQLAEETQGFQRTLE 2506
Query: 2589 AQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILS 2648
A+ ++ L ++ + +++++ + E + + + E+ +
Sbjct: 2507 AERQRQL------------------EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE 2548
Query: 2649 RPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSD 2708
GE + ++ + Q + Q + + +AI + + + L+
Sbjct: 2549 EIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ------- 2601
Query: 2709 LDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCED----LSALVKEE 2764
+ KL + Q L+ Q ++Q EK + + E L L ++E
Sbjct: 2602 -EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDE 2660
Query: 2765 YLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQN 2824
KA+ R+ + + + +EQ+ + V ++ A H+ ++ R Q L ++++
Sbjct: 2661 VAKAQQLREEQ--QRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRR 2718
Query: 2825 KSHPISA--------KLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLL 2868
+ + A +L +LE + S+ +TA KT+ G + L
Sbjct: 2719 QQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDAL 2770
Score = 563 bits (1452), Expect = e-159
Identities = 270/450 (60%), Positives = 361/450 (80%), Gaps = 1/450 (0%)
Query: 71 DERDKVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEVLSGDTLPREKGRMRF 130
DERD+VQKKTFTKW+N+HL+K ++H++DLYEDLRDGHNLISLLEVLSGD+LPREKGRMRF
Sbjct: 175 DERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRF 234
Query: 131 HRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIHVTGESED 190
H+LQNVQIALDYL+ RQVKLVNIRNDDI DGNPKLTLGLIWTIILHFQISDI V+G+SED
Sbjct: 235 HKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSED 294
Query: 191 MSAKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAVQSNLA 250
M+AKE+LLLW+Q+ EGY G+RC+NFT+ WRDG+LFNAIIH+++P LIDMN V Q+NL
Sbjct: 295 MTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLE 354
Query: 251 NLEHAFYVAEK-IGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAFPKVPEGGEGIGANDV 309
NL+ AF VAE+ +GV RLLDPEDVDV PDEKS+ITYVSSLYDA P+VP+ +G+ AN++
Sbjct: 355 NLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANEL 414
Query: 310 EVKWIEYQNMVNYLIQWIRHHVTTMSERTFPNNPVELKALYNQYLQFKETEIPPKETEKS 369
+++W EY+ +V L+QW+RHH ER FP++ E++ L++Q+L+FKE E+P KE +K+
Sbjct: 415 QLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKN 474
Query: 370 KIKRLYKLLEIWIEFGRIKLLQGYHPNDIEKEWGKLIIAMLEREKALRPEVERLEMLQQI 429
+ K +Y+ LE ++ G++K+ GYHP D+EKEWGKL +A+LEREK LR E ERLE LQ+I
Sbjct: 475 RSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRI 534
Query: 430 ANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLLRQHVIDVQ 489
++Q ++ +CE++L A LQSD + L +G Q E+ + + ++++R DVQ
Sbjct: 535 VTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQ 594
Query: 490 ILIDGKYYQADQLVQRVAKLRDEIMALRNE 519
L DG++ Q +Q+ +RV +L + ++A+R E
Sbjct: 595 TLKDGRHPQGEQMYRRVYRLHERLVAIRTE 624
Score = 111 bits (277), Expect = 2e-23
Identities = 355/1874 (18%), Positives = 725/1874 (38%), Gaps = 306/1874 (16%)
Query: 2676 GQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQK 2735
G S + Q++ + Q +S + +L D+ +L + + H + E A++
Sbjct: 1096 GSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARE 1155
Query: 2736 MKQEI-QQEKKQIKVA---------QALCEDLSALVKEEYLKAELSRQLEGILKSFKDVE 2785
Q I +Q+K Q +V A E + AL + L +LE L + V
Sbjct: 1156 CAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVR 1215
Query: 2786 QKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKD 2845
+ +++ L++ Q +A + KE Q + A L LE+ K
Sbjct: 1216 SLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQ----AVPATLPELEAT----KA 1267
Query: 2846 FSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQ----------------LNTIKTN 2889
K L AQ+ + T + L + +G+++ +LQ + +
Sbjct: 1268 SLKKLRAQAEAQQPTF---DALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLER 1324
Query: 2890 WDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFC--LDPAEGENS 2947
W Q R+ +L++ + Y+E + L W+ + E+I+ D
Sbjct: 1325 WQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQ 1384
Query: 2948 IAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSK 3007
+ + ++L +E+++H VE A ++ K
Sbjct: 1385 LRQEQALLEEIERHGEKVEECQRFAKQYINAI---------------------------K 1417
Query: 3008 KFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQA 3067
+ L+ +T K + S K ++Q E + I + + + + ++ T+ K +
Sbjct: 1418 DYELQLVTYKAQLEPVASPAKKPKVQSGSESV-IQEYVDLRTHYSELTTLTSQYIKFISE 1476
Query: 3068 LKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVET-IAQEHSTLSQQVDEKCSFLETKLQG 3126
+++ +RLA+ E + + L+ + +A+ H+ Q + + L+ ++Q
Sbjct: 1477 TLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ- 1535
Query: 3127 IGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKET-IKAFLKKLEALMASNDNA 3185
E+ + D + + + L++ E I+A ++ EA S
Sbjct: 1536 --------EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRI 1587
Query: 3186 NKTCKMM-LATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKL 3244
+ +++ L E T G + +L+AL +AR E+ E ++ +E +L
Sbjct: 1588 EEEIRVVRLQLEATERQRGGAEGELQAL-----------RARAEEAEAQKRQAQEEAERL 1636
Query: 3245 KEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLI 3304
+ + +ESQ E E ++ K E E + KQ+ + L + +
Sbjct: 1637 RR--------QVQDESQRKRQAEVELASRV--------KAEAEAAREKQRALQALEELRL 1680
Query: 3305 QSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVD 3364
Q+ + L + +RA Q+Q AL
Sbjct: 1681 QAEEAE-----------------RRLRQAEVERARQVQVAL------------------- 1704
Query: 3365 TEELVANQKPPSAEFKVVKAQIQEQKL-LQRLLDDRKSTVEVIKREGEKIATTAEPADKV 3423
Q+ AE + +A E+ L+R L + V ++ E E+ A A++
Sbjct: 1705 ----ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERA 1760
Query: 3424 KILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEP 3483
+ + L RW+ N+A Q E VAQQ + L + EK+ E
Sbjct: 1761 REEAEREL--ERWQLKANEALRLRLQAEE---VAQQ-----KSLAQ--AEAEKQKEEAER 1808
Query: 3484 IGTQASKLEEQIAQHKALEDDIINHNKHLHQAVS---IGQSLKVLSSREDKDMVQSKLDF 3540
+ K EEQ + + L + + + L + + + +++ R + + + +
Sbjct: 1809 EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL 1868
Query: 3541 SQVWYIEIQEKSHSRSELLQQALCN-AKIFGEDEVELMNWLN--EVHDKLSKLSVQDYST 3597
+ +Q ++ + ++ Q+ AK+ E EV L + E S+ S Q
Sbjct: 1869 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1928
Query: 3598 EG-----LWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKA 3652
E L ++ + LR L E+ ++Q ++ + +Q E ++ +KL AI
Sbjct: 1929 EAGRFRELAEEAARLRALAEEAKRQRQLAEE------DAARQRAEAE-RVLAEKLAAIG- 1980
Query: 3653 RYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQA 3712
+ T+L T+ L++ RL E+ ++E + ++ + E A
Sbjct: 1981 ---EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI----EERLA 2033
Query: 3713 QMRPKELKKEAKNNKALL-DSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTIT 3771
Q+R K E + K L+ D+L + E++ +A EK A E
Sbjct: 2034 QLR-KASDSELERQKGLVEDTLRQRRQVEEEILALKA--SFEKAAAGKAEL--------- 2081
Query: 3772 QKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTME 3831
E++ +RS D E + + ++ ++ + E+ + A+ +VQK+ E
Sbjct: 2082 ----ELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEE---ERRRREAEERVQKSLAAE 2134
Query: 3832 ---ILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLE- 3887
+ K ++++ + K+ EE + ++++ ++ + Q +++ LQ E
Sbjct: 2135 EEAARQRKAALEEVERLKAKV------EEARRLRERAEQESARQLQLAQEAAQKRLQAEE 2188
Query: 3888 RAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPH 3947
+A + Q E +EL L + QS++ QL A E R+ EE + R
Sbjct: 2189 KAHAFAVQQKE--QELQQTLQQEQSVLDQLRGEA---EAARRAAEEAEEARVQAEREAAQ 2243
Query: 3948 IDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQST----- 4002
+ + +L + + + + + AA+ L + +++ +RA A A+ Q
Sbjct: 2244 SRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAE 2303
Query: 4003 -QFHDK-----------IDQILESLE-RIVERLRQPPSISAEVEKIKEQISENK------ 4043
+ H K ++Q L +L ++ E Q + E++++K + +E
Sbjct: 2304 MEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQV 2363
Query: 4044 -----NVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHT 4098
+V V ME+L L ++ +I R DKD + + +Q++ ++M + E
Sbjct: 2364 EEELFSVRVQMEELSKLKARIEAENRALILR----DKDNTQRFLQEEAEKMKQVAEEAAR 2419
Query: 4099 L-VEEREAKLLDVMELAEKFWCDHMSLIVT-IKDTQDFIRDLEDPGIDPSVVKQQQEAAE 4156
L V +EA L +LAE+ +L +K+ +++ + +++QQ+E A+
Sbjct: 2420 LSVAAQEAARL--RQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ 2477
Query: 4157 TIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKL 4216
E+ LQE+ + ++ E + + E + +A + ++ ++
Sbjct: 2478 ---EQARRLQEDKE-------QMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKL-RV 2526
Query: 4217 EEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQI 4276
E +A + ++ Q + G KL + T+ Q +E I
Sbjct: 2527 AEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE-------------I 2573
Query: 4277 EMERLNHQAELLLKKVTE-ESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQ 4335
+ ++ +H AE L + + E E +K +Q E KL+ EE +Q +L AL Q
Sbjct: 2574 QRQQSDHDAERLREAIAELEREKEKLQQ---EAKLLQLKSEEMQTVQQEQLLQETQALQQ 2630
Query: 4336 FQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEI----ELAKHHVLQNDVLAHQSTVEAV 4391
++L+ + LL ++ + + +E E+AK L+ + Q +E
Sbjct: 2631 ---------SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQE 2681
Query: 4392 NKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIED 4451
+ L+ S EEA Q++ E +R Q L++ EQ+++Q + L + + + +
Sbjct: 2682 RQR---LVASM--EEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEE---NQRLRE 2733
Query: 4452 LQQWLTDTERHLLA 4465
Q L + R LA
Sbjct: 2734 QLQLLEEQHRAALA 2747
Score = 94.0 bits (232), Expect = 4e-18
Identities = 353/1847 (19%), Positives = 705/1847 (38%), Gaps = 283/1847 (15%)
Query: 3201 DLVGIKRDLEALSKQCNKLLDRAQ--AREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHE 3258
D + +R+ + S +LL + A+EE R + S+LK+ + L+ E
Sbjct: 1087 DRLMAEREYGSCSHHYQQLLQSLEQGAQEES------RCQRCISELKDIRLQLEACETRT 1140
Query: 3259 ESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAK--------- 3309
+ + ++ E + + I Q Q +V LG+G+ + +A+
Sbjct: 1141 VHRLRLPLDKEPARECA--------QRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPE 1192
Query: 3310 -STSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEEL 3368
S + L +L+ + + + A +L+ L Q A E L + +E
Sbjct: 1193 PSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEA 1252
Query: 3369 VA------NQKPPSAEFKVVKAQIQ-EQKLLQRLLDDRKSTVEVIKREGEKIATTAEPAD 3421
A + A K ++AQ + +Q L D+ + EV +R ++ +
Sbjct: 1253 QAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVE 1312
Query: 3422 KVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNC 3481
+ + ++++ L RW+A+L + + R R+LE + + + E+ +PL WL +R
Sbjct: 1313 RWR--ERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQI 1370
Query: 3482 EPIGTQASK-LEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDF 3540
+ + S+ + EQ+ Q +AL ++I H + + + + + +V K
Sbjct: 1371 QAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQL 1430
Query: 3541 SQVWYIEIQEKSHSRSELLQQALCNAKI-FGEDEVELMNWLNEVHDKLSKLSVQDYSTEG 3599
V + K S SE + Q + + + E ++ + + L ++ ++ E
Sbjct: 1431 EPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE- 1489
Query: 3600 LWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITK 3659
+Q++E R R V+ AL +L + Q K +A + + +
Sbjct: 1490 --QQRAEERE-------RLAEVEAALEKQRQLAEAHA-------QAKAQAEREAKELQQR 1533
Query: 3660 LSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKEL 3719
+ +V + E A+ ++ S EEL E E+ + K +A A+ +
Sbjct: 1534 MQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQA------KARQAEAAERSRLRI 1587
Query: 3720 KKEAKNNKALLDSL-NEVSSALLELVPWRAR----EGLEKMVAEDNERYRLVSDTITQKV 3774
++E + + L++ + A EL RAR E ++ E+ ER R +Q+
Sbjct: 1588 EEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRK 1647
Query: 3775 EEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILR 3834
+ + + AE E ++ L +L ++RL+ ++ +L+ E+ R
Sbjct: 1648 RQAEV------ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR-----QAEVER 1696
Query: 3835 HKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVN 3894
+ V+ + +E E QS + +E+ QLER+
Sbjct: 1697 ARQ-----VQVALETAQRSAEAELQSKRASF--------------AEKTAQLERS----- 1732
Query: 3895 QFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKT 3954
L E ++QL E E QQQ E + RE E + +++
Sbjct: 1733 ------------LQEEHVAVAQLRE---EAERRAQQQAEAERARE---EAERELERWQLK 1774
Query: 3955 GPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILES 4014
+ L L Q+K +A Q KE+ ++ A +A Q+ + + +Q LE
Sbjct: 1775 ANEALRLRLQAEEVAQQKSLAQAEAEKQ-KEEAEREARRRGKAEEQAVRQRELAEQELEK 1833
Query: 4015 LERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTD 4074
++ E Q ++AE E I+ + + E+ + L E R + A +
Sbjct: 1834 QRQLAEGTAQ-QRLAAEQELIRLRAETEQG-----EQQRQLLEEELARLQREAAAATQKR 1887
Query: 4075 KDISAKAVQDKLDQMVFIWENIHTLVEER----------EAKLLDVMELAEKFWCDHMSL 4124
+++ A+ + + + V + E R EA+ ELAE+ +
Sbjct: 1888 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE-----AAR 1942
Query: 4125 IVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQE------ELDIVI---NL 4175
+ + + R L + +Q+ EA + E++ + E E +I +
Sbjct: 1943 LRALAEEAKRQRQL----AEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEA 1998
Query: 4176 GSELIAACGEPDKPIVKKSIDE--------LNSAWDSLNKAWKDRIDK----LEEAMQAA 4223
+E + E D+ ++ ++E + L KA +++ +E+ ++
Sbjct: 1999 ENERLRRLAE-DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQR 2057
Query: 4224 VQYQDGLQAV-FDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQ---IEME 4279
Q ++ + A+ + A GK +G + + +Q + EA +Q+ E E
Sbjct: 2058 RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE 2117
Query: 4280 RLNHQAELLLKK--VTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQ 4337
R +AE ++K EE + L E++ + +EE R+ + + L Q
Sbjct: 2118 RRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ 2177
Query: 4338 HALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAH-QSTVEAVNKAGN 4396
A + L +QK E EL + + VL + EA +A
Sbjct: 2178 EAAQKRLQAEEKAHAFAVQQK---------EQELQQTLQQEQSVLDQLRGEAEAARRAAE 2228
Query: 4397 DLIES--SAGEEASNLQNKLEVLNQRWQNVLEKTEQ-----------RKQQLDGALRQAK 4443
+ E+ A EA+ + ++E + Q+ E+ + RK+ A R+A+
Sbjct: 2229 EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQ 2288
Query: 4444 GFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEET--YKSLM 4501
+ Q + E+H ++ +T +++ V E+ EET K+L+
Sbjct: 2289 AEQAALRQKQAADAEMEKHKKFAE------QTLRQKAQVEQELTTLRLQLEETDHQKNLL 2342
Query: 4502 QKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNE---RKTKLE-EALNLAMEFHNS 4557
+ Q L K+ T + + ++E+ SV ++ E K ++E E L + ++
Sbjct: 2343 DEELQRL----KAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDN 2398
Query: 4558 LQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLK 4617
Q F+ +AE+ VA + L + + A E + + + E K
Sbjct: 2399 TQRFLQ--EEAEKMKQVAEEAAR-LSVAAQEAARLRQLAEEDLAQQRALAE--------K 2447
Query: 4618 YFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSL-DDARKRAKQFHEAWSKLMEWLEE 4676
+K V L + ++ + E+ R L +D + A+Q E LE
Sbjct: 2448 MLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA 2507
Query: 4677 SEKSLDSELEIANDPDKIKTQLAQ--------HKEFQKSLGAKHSVYDTTNRTGRSLKEK 4728
+ +LE++ + +++K ++A+ ++ Q+ + + +RT + +EK
Sbjct: 2508 ERQ---RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEK 2564
Query: 4729 TSLAD-----------DNLKLDDMLSELRDKWDTICG-------KSVERQNKLEEALLFS 4770
+L D +L + ++EL + + + KS E Q +E LL
Sbjct: 2565 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLL-- 2622
Query: 4771 GQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKR 4830
Q T ALQ +L + L ++ + + + L + A ++L + Q
Sbjct: 2623 -QETQALQQ--SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2679
Query: 4831 SARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLE 4890
R+ + S +++ + + +E R + + +LE RQ EE
Sbjct: 2680 QERQRLVASMEEARRRQHEAEEGVRRKQ-------EELQQLEQQRRQQEEL--------- 2723
Query: 4891 WLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKAT 4937
LAE Q LR + L+ L +QH+ + EE A AT
Sbjct: 2724 -LAEENQRLR---------EQLQLLEEQHRAALAHSEEVTASQVAAT 2760
Score = 85.1 bits (209), Expect = 2e-15
Identities = 295/1541 (19%), Positives = 608/1541 (39%), Gaps = 226/1541 (14%)
Query: 3708 EASQAQMRPKELKKEAKNNKALLDSLN-------EVSSAL--------LELVPWRAREGL 3752
EA++A + K+L+ +A+ + D+L EV L +E+ WR R
Sbjct: 1263 EATKASL--KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRER--- 1317
Query: 3753 EKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIR 3812
VA+ ER++ V + E++ + + + ++AD +W+ + ++ + +
Sbjct: 1318 ---VAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1374
Query: 3813 LEQDQT-SAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQ--SMKKKLDKVL 3869
L Q QL+ ++ EI RH + +++ + + + A + E Q + K +L+ V
Sbjct: 1375 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA 1434
Query: 3870 KNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQ 3929
+ + QS + Y +L +E ++ SQ ETLR+
Sbjct: 1435 SP------------AKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIK--FISETLRR 1480
Query: 3930 QQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKK 3989
+EE R + AE + + ++ + +L+ + + A L +++E+V +
Sbjct: 1481 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1540
Query: 3990 RAVALDEAISQSTQFHDKIDQILESLERIVE-RLRQPPSISAEVEKIKEQISENKNVSVD 4048
R A +A Q +++ Q+ +S E ++ + RQ + +I+E+I
Sbjct: 1541 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR-------- 1592
Query: 4049 MEKLQPLYETLKQRG----EEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEERE 4104
+ +LQ L T +QRG E R+ + + + Q++ +++ + +E +
Sbjct: 1593 VVRLQ-LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLR------RQVQDESQ 1645
Query: 4105 AKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIRE-EID 4163
K +ELA + + + ++ Q ++ LE+ + Q +EA +R+ E++
Sbjct: 1646 RKRQAEVELASRVKAEAEAA----REKQRALQALEELRL------QAEEAERRLRQAEVE 1695
Query: 4164 GLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWD-SLNKAWKDRIDKLEEAMQA 4222
++ + + E E + + S E + + SL + EEA +
Sbjct: 1696 RARQ-----VQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERR 1750
Query: 4223 AVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLN 4282
A Q + +A + A +L + ++ Q EE+ Q KS A Q E E+
Sbjct: 1751 AQQQAEAERAREE----AERELERWQLKANEALRLRLQAEEVAQQKSLA---QAEAEKQK 1803
Query: 4283 HQAELLLKKVTEESDKHTVQDPLMELKLIWD-SLEERIINRQHKLEGALLALG------- 4334
+AE ++ + ++ Q L E +L L E ++ E L+ L
Sbjct: 1804 EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1863
Query: 4335 QFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKA 4394
Q + L+E LA L ++++ + +E ELAK +LA ++ E +++
Sbjct: 1864 QQRQLLEEELARLQREAAAATQKR------QELEAELAKVRAEMEVLLASKARAEEESRS 1917
Query: 4395 GNDL----IESSAG------EEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKG 4444
++ +E+ AG EEA+ L+ E ++ Q E +++ + + L +
Sbjct: 1918 TSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLA 1977
Query: 4445 FHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKG 4504
GE L+ TE + + E E+L + AF+ + ++ K
Sbjct: 1978 AIGEATRLK-----TEAEIALKEK-----EAENERLR-RLAEDEAFQRRRLEEQAAQHKA 2026
Query: 4505 --QQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFI 4562
++ LA+ K++++ +++ VE L +R+ EE L L F +
Sbjct: 2027 DIEERLAQLRKASDSELERQKG-------LVEDTLRQRRQVEEEILALKASFEKAAAG-- 2077
Query: 4563 NWLTQAEQTLNVASRPSLILDTV-------LFQIDEHKVFANEVNSHREQIIELDKTGTH 4615
+AE L + S DT+ L + ++ A E RE + K+
Sbjct: 2078 ----KAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAA 2133
Query: 4616 LKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLE 4675
+ ++++ L + V+RL + R+RA+Q E+ +L E
Sbjct: 2134 EEEAARQRKAAL-------------EEVERLKAKVEEARRLRERAEQ--ESARQLQLAQE 2178
Query: 4676 ESEKSLDSELEIANDPDKIKTQLAQHKE--FQKSLGAKHSVYDTTNRTGRSLKEKTSLAD 4733
++K L +E +K Q KE Q++L + SV D + + A+
Sbjct: 2179 AAQKRLQAE-------EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE 2231
Query: 4734 D-NLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLA 4792
+ ++ + ++ R + VE +L+++ Q QA + L + Q A
Sbjct: 2232 EARVQAEREAAQSR--------RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2283
Query: 4793 E-----DQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVK 4847
+Q ++ HK F ++ ++ + V+ + R +E + + +
Sbjct: 2284 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2343
Query: 4848 VQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPD 4907
++Q L + L + Q EE L+ EAE ++
Sbjct: 2344 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSK-----LKARIEAEN----RALILR 2394
Query: 4908 DEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFE 4967
D+D + + + E MK++ E+ A L+ A + + D + RA E
Sbjct: 2395 DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED--------LAQQRALAE 2446
Query: 4968 EVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALI 5027
++L K+ Q + A L A+ ELL+ Q L + +++ Q EE +
Sbjct: 2447 KML---KEKMQAVQEA-TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGF- 2501
Query: 5028 AEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSG 5087
Q +E ++Q ++ + K R A+ S Q+ + A R R A +
Sbjct: 2502 ---QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA----EEDAQRFRKQAEEIGEKL 2554
Query: 5088 SQTQIETKNPRVNLLVSKWQQVWLLALERRR------KLNDALDRLEELREFANFDFDIW 5141
+T++ T+ K V L ++R++ +L +A+ LE +E + +
Sbjct: 2555 HRTELATQ--------EKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL 2606
Query: 5142 RKKYMRWMNHKKSRVMDFFRRIDK----DQDGKITRQEFID 5178
+ K ++ +++ + + + ++D + R+ FI+
Sbjct: 2607 QLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE 2647
Score = 78.6 bits (192), Expect = 2e-13
Identities = 352/1885 (18%), Positives = 731/1885 (38%), Gaps = 251/1885 (13%)
Query: 3336 QRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRL 3395
QR +L+++ L L+ LL+W+ + + V + + V+AQ+ + L +
Sbjct: 649 QRRPELEDSTLRY------LQDLLAWVEENQHRVDGAEW-GVDLPSVEAQLGSHRGLHQS 701
Query: 3396 LDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGI-S 3454
+++ ++ +E + + +++ PA + L LD ++ LLN ++ R R LE + S
Sbjct: 702 IEEFRAKIERARSDEGQLS----PATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHS 757
Query: 3455 VVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQ 3514
VA E + WL E+ V + + + + + + AL ++ K + +
Sbjct: 758 FVAAATKELM-----WLNEKEEEEVGFD-WSDRNTNMTAKKESYSALMRELELKEKKIKE 811
Query: 3515 AVSIGQSL--KVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGED 3572
+ G L + +R + Q+ L W +LQ C
Sbjct: 812 LQNAGDRLLREDHPARPTVESFQAALQTQWSW-------------MLQLCCC-------- 850
Query: 3573 EVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQ-ALLNGLEL 3631
E H K + Q +S + + + +L+ LQE L RK + D+ A + LE
Sbjct: 851 --------IEAHLKENAAYFQFFS--DVREAEGQLQKLQE-ALRRKYSCDRSATVTRLED 899
Query: 3632 LKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDK 3691
L Q DE +++L K + +AK + +QL R H H
Sbjct: 900 LLQDAQDE----KEQLNEYKGHL-------SGLAKRAKAVVQLKPR-HPAHPMRGRLPLL 947
Query: 3692 VEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVS-SALLELVPWRARE 3750
+ E V KG+E + + K L S +E + ++ LVP +E
Sbjct: 948 AVCDYKQVEVTVHKGDECQLVG------PAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQE 1001
Query: 3751 GLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGD 3810
E + + + LV T+ ++ ++L Q + SW T + L
Sbjct: 1002 AQEAVTRLEAQHQALV--TLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKP--- 1056
Query: 3811 IRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLK 3870
EQ Q L+ L ++ + D +G E++ +++
Sbjct: 1057 --EEQRQALHSLE---------LHYQAFLRDSQDAG-----GFGPEDRLMAEREYGSCSH 1100
Query: 3871 NYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQ 3930
+Y + Q + + R Q +++ + +L T T + +L P
Sbjct: 1101 HYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRT---VHRLRLPL--------D 1149
Query: 3931 QEEHRQLRELIAEHKPHIDKMNKTGPQLLELS--PGEGFSIQEKYVAADTLYSQIKEDVK 3988
+E R+ + IAE + ++ G + LS + ++ E AA TL S+++ +
Sbjct: 1150 KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLG 1209
Query: 3989 KRAVALDEAISQSTQFHDKIDQIL----------ESLERIVERLRQPPSISAEVEKIKEQ 4038
K L++ S S + +K+ I E L E+L++ ++ A + +++
Sbjct: 1210 K----LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEAT 1265
Query: 4039 ISENKNVSVDMEKLQPLYETLKQR-------GEEMIARSGGTDKDISAKAVQDKLDQMVF 4091
+ K + E QP ++ L+ GE + R G ++D+ + ++++ Q++
Sbjct: 1266 KASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHG--ERDVEVERWRERVAQLLE 1323
Query: 4092 IWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLED-PGIDPSVVKQ 4150
W+ + + R+ +L + + L ++D + ++ P D V++
Sbjct: 1324 RWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVRE 1383
Query: 4151 QQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIV--KKSID---------ELN 4199
Q + + EEI+ E+++ + I A + + +V K ++ ++
Sbjct: 1384 QLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQ 1443
Query: 4200 SAWDSLNKAWKDRIDKLEEAMQAAVQY----QDGLQAVFDWVDIAGGKLAS----MSPIG 4251
S +S+ + + D E QY + L+ + + +A + A ++ +
Sbjct: 1444 SGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVE 1503
Query: 4252 TDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKK---VTEESDKHTVQDPLMEL 4308
LE +Q E Q K++A ++ E+++ Q E++ ++ V + K ++Q+ L +L
Sbjct: 1504 AALEKQRQLAEAHAQAKAQAEREAKELQQ-RMQEEVVRREEAAVDAQQQKRSIQEELQQL 1562
Query: 4309 KLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIE 4368
+ S E I + + E A + + + + + L TE + GG ++
Sbjct: 1563 R---QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATE------RQRGGAEGELQ 1613
Query: 4369 IELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEE---ASNLQNKLEVLNQRWQNVL 4425
A+ + Q E + + D + E AS ++ + E ++ Q L
Sbjct: 1614 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREK-QRAL 1672
Query: 4426 EKTEQRKQQLDGALRQAKGFHGEIE---DLQQWLTDTERHL---LASKPLGGLPETAKEQ 4479
+ E+ + Q + A R+ + E+E +Q L +R L SK +TA+ +
Sbjct: 1673 QALEELRLQAEEAERRLR--QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE 1730
Query: 4480 LNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNE 4539
++ E A + +EE + Q+ + AR E E +L
Sbjct: 1731 RSLQEEHVAVAQLREEAERRAQQQAEAERAR--------------------EEAERELER 1770
Query: 4540 RKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEV 4599
+ K EAL L ++ Q +AE+ A R + Q + A +
Sbjct: 1771 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1830
Query: 4600 NSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKR 4659
+ Q+ E GT + + +Q+++ ++ + + + + + L R A ++
Sbjct: 1831 LEKQRQLAE----GTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK 1886
Query: 4660 AKQFHEAWSKL---MEWLEESEKSLDSELEIANDPDK--IKTQLAQHKEFQKSLGAKHSV 4714
++ +K+ ME L S+ + E ++ K ++ + + +E + ++
Sbjct: 1887 RQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRAL 1946
Query: 4715 YDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFT 4774
+ R R L E+ + A + + +L+E G++ + + E AL
Sbjct: 1947 AEEAKRQ-RQLAEEDA-ARQRAEAERVLAEKL----AAIGEATRLKTEAEIALKEKEAEN 2000
Query: 4775 DALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARE 4834
+ L+ L + + + E+Q D+ L KA EL ++ V+ R R+
Sbjct: 2001 ERLRRLAE-DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQ 2059
Query: 4835 L------IEGSRDDSSWVKVQMQ-ELS-TRWETVCALSISKQTRLEAALRQ---AEE--- 4880
+ ++ S + ++ K +++ EL R L +Q LEAA ++ AEE
Sbjct: 2060 VEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERR 2119
Query: 4881 FHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRA-ELNKATTM 4939
+ + LA E+ R ++ + L+ +++ + ++ E++ A +L A
Sbjct: 2120 RREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA 2179
Query: 4940 GDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQ----QRLASALAGLIAKQELLE 4995
L K ++ + +E+ +Q Q Q A A A +E E
Sbjct: 2180 AQKRLQ-------AEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2232
Query: 4996 A-LLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRR 5054
A + A + A++ ++ E + Q EE A+ Q E++ RK+ + + +R
Sbjct: 2233 ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL-RKEAEQEAA----RRA 2287
Query: 5055 AADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGS--------QTQIETKNPRVNLLVSKW 5106
A+ ++L+ D K+F +L + Q+E + + NLL +
Sbjct: 2288 QAEQAALRQK-QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEEL 2346
Query: 5107 QQVWLLALERRRKLNDALDRLEELR 5131
Q++ A E R+ + + L +R
Sbjct: 2347 QRLKAEATEAARQRSQVEEELFSVR 2371
Score = 69.3 bits (168), Expect = 1e-10
Identities = 208/1057 (19%), Positives = 422/1057 (39%), Gaps = 142/1057 (13%)
Query: 4258 KQQIEELKQFKSEAYQQQIEME-------RLNHQAELLLKKVTEESDKHTVQDPLMELKL 4310
K+ E Q +E + Q E+E RL+ +AE +L T++ EL+L
Sbjct: 1150 KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRS---ELEL 1206
Query: 4311 IWDSLEE-RIINRQH--KLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAI 4367
LE+ R ++ + KL+ L + Q A + L A E L E + V +
Sbjct: 1207 TLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAH----EEQLKEAQAVPATLPEL 1262
Query: 4368 EIELAKHHVLQNDVLAHQSTVEAVN------KAGNDLIESSAGE---EASNLQNKLEVLN 4418
E A L+ A Q T +A+ + + ++ GE E + ++ L
Sbjct: 1263 EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLL 1322
Query: 4419 QRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTER--HLLASKPLGGLPETA 4476
+RWQ VL +T+ R+++L+ RQ + + + L WL D R + + PL +
Sbjct: 1323 ERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLAD-SQAV 1381
Query: 4477 KEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETK 4536
+EQL +E+ +++ + + C + A+ Q IN +K+ E +
Sbjct: 1382 REQLR-----------QEQALLEEIERHGEKVEECQRFAK----QYINAIKD----YELQ 1422
Query: 4537 LNERKTKLEEALNLAME------FHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQID 4590
L K +LE + A + + +Q++++ T + + S+ + L +++
Sbjct: 1423 LVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRME 1482
Query: 4591 EHKVFAN-----------EVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRW 4639
E + A EV + E+ +L + K ++++ L + + V R
Sbjct: 1483 EEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRRE 1542
Query: 4640 EKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLA 4699
E V ++ RS+ + ++ +Q EA ++ ++E + S L I + ++ QL
Sbjct: 1543 EAAVDAQQQK-RSIQEELQQLRQSSEA--EIQAKARQAEAAERSRLRIEEEIRVVRLQL- 1598
Query: 4700 QHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVER 4759
+ E Q+ GA+ + R + +K ++ + + +++D+ VE
Sbjct: 1599 EATERQRG-GAEGELQALRARAEEAEAQKRQAQEE---AERLRRQVQDESQRKRQAEVEL 1654
Query: 4760 QNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDID----LVMNLIDNHKAFQ 4815
++++ + + ALQAL + R++ + AE + +++ + + L ++ +
Sbjct: 1655 ASRVKAEAEAAREKQRALQALEE--LRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1712
Query: 4816 KELGKRTSS----VQALKRSARE---LIEGSRDDSSWVKVQMQELS----------TRWE 4858
EL + +S L+RS +E + R+++ Q E RW+
Sbjct: 1713 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ 1772
Query: 4859 TVCALSISKQTRLEAALRQAEEFHSVVHALLE-WLAEAEQTLRFHGVLPDDEDALRTLID 4917
L ++ RL + + S+ A E EAE+ R G + R L +
Sbjct: 1773 ----LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAE 1828
Query: 4918 QHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQ 4977
Q E ++L E A+ A + + + + + AR + A A Q +
Sbjct: 1829 QELEKQRQLAEGTAQQRLAAEQ-ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKR 1887
Query: 4978 QRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEM 5037
Q L + LA + A+ E+L A A + + ++K K+ + E + L EE
Sbjct: 1888 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL-------AEEA 1940
Query: 5038 TRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETKNP 5097
R + ++ K ++ A + ++ Q RA +R A L G T+++T+
Sbjct: 1941 ARLRALAEE-AKRQRQLAEEDAARQ---------RAEAERVLAEKLAAIGEATRLKTEAE 1990
Query: 5098 RVNLLVSKWQQVWLLALERRRKLNDALDRLEELREFANFDFDIWRKKYMRWMNHKKSRVM 5157
+AL+ + N+ L RL E F R++ K+ +
Sbjct: 1991 --------------IALKEKEAENERLRRLAEDEAFQ-------RRRLEEQAAQHKADIE 2029
Query: 5158 DFFRRIDKDQDGKITRQE-FIDGILSSKFPTSRLEMSAVADIFDRDGDGYIDYYEFVAAL 5216
+ ++ K D ++ RQ+ ++ L + E+ A+ F++ G + + +
Sbjct: 2030 ERLAQLRKASDSELERQKGLVEDTLRQRRQVEE-EILALKASFEKAAAGKAELELELGRI 2088
Query: 5217 HPNKDAYKPITDADKIEDEVTRQVAKCKCAKRFQVEQ 5253
N + + ++E RQ+A + +R + E+
Sbjct: 2089 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEE 2125
Score = 40.0 bits (92), Expect = 0.064
Identities = 84/510 (16%), Positives = 207/510 (40%), Gaps = 52/510 (10%)
Query: 1078 EKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQI-RTPLER 1136
+ E+ K++ ++ L+ + EQE + L + E + + L+ RL + +R
Sbjct: 2301 DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR 2360
Query: 1137 DDLHESVFRITEQ----EKLKKELER----------------LKDDLGTITNKCEEFFSQ 1176
+ E +F + Q KLK +E L+++ + EE
Sbjct: 2361 SQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARL 2420
Query: 1177 AAASSSVPTLRSELNVVLQNMNQVYSMSSTYI-DKLKTVNLVLKNTQAAEALVKLYETKL 1235
+ A+ LR + +++ Q +++ + +K++ V + AE L + E
Sbjct: 2421 SVAAQEAARLRQ---LAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ 2477
Query: 1236 CEEEAVIADKNNI-ENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERD 1294
+ + DK + + L + ++ ++ +RQ + E ++ K EM + +
Sbjct: 2478 EQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAE 2537
Query: 1295 LDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQR 1354
D +++A+++ E+ + ++ ++ + + L + I ++E +
Sbjct: 2538 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKE 2597
Query: 1355 KIQ-ENQPENSKTLATQLNQQKMLVSEIE-MKQSKMDEC------QKYAEQYSATVKD-Y 1405
K+Q E + K+ Q QQ+ L+ E + ++QS + E +++ EQ A ++ +
Sbjct: 2598 KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLF 2657
Query: 1406 ELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRY--------------TALV 1451
+ + + + + QQ+ ++++M+ ++ + R R L
Sbjct: 2658 QDEVAKAQQLREEQQR---QQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE 2714
Query: 1452 TLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPF 1511
Q + + +RL E+ + LEE+ + + ++E+ +KTL + A P
Sbjct: 2715 QQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPA 2774
Query: 1512 SKQKISSEEISTKKEQLSEALQTIQLFLAK 1541
++ + +++ ++ LQ + A+
Sbjct: 2775 AEAEPEHSFDGLRRKVSAQRLQEAGILSAE 2804
Score = 35.0 bits (79), Expect = 2.1
Identities = 73/348 (20%), Positives = 135/348 (38%), Gaps = 54/348 (15%)
Query: 4633 ISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLM-------EWLEESEKSLDSEL 4685
+ V+ W K+ ++ER + L +R + +KL E L +++ L S++
Sbjct: 501 LDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDV 560
Query: 4686 -------------EIANDPDKIKTQLAQ-HKEFQKSLGAKHSVYDTTNRTGRSLKEKTSL 4731
E+ D DK + + + Q +H + R L E+
Sbjct: 561 RLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVA 620
Query: 4732 --ADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEP 4789
+ NL+L ++ + + +SV+R+ +LE++ L LQ L+ W+ E
Sbjct: 621 IRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTL------RYLQDLLAWVE--EN 672
Query: 4790 QLAEDQPVHG-DIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSR----DDSS 4844
Q D G D+ V + +H+ + + + + ++ + +L +R D
Sbjct: 673 QHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLG 732
Query: 4845 WVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHAL---LEWLAEAEQTLRF 4901
+ +Q +L L+ SK A LR E HS V A L WL E E+
Sbjct: 733 RLDLQYAKL---------LNSSK-----ARLRSLESLHSFVAAATKELMWLNEKEEE-EV 777
Query: 4902 HGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHP 4949
D + + + M++LE K ++ + GD +L HP
Sbjct: 778 GFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHP 825
Score = 35.0 bits (79), Expect = 2.1
Identities = 22/51 (43%), Positives = 26/51 (50%)
Query: 5433 EDSGLITTAAARVRTQFADSKKTPSRPGSRAGSKAGSRASSRRGSDASDFD 5483
E +GL AA T+ S + S GS AGS+ GSR SR GS FD
Sbjct: 4594 EGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTGSRTGSRAGSRRGSFD 4644
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 861 bits (2224), Expect = 0.0
Identities = 637/2272 (28%), Positives = 1151/2272 (50%), Gaps = 200/2272 (8%)
Query: 641 EEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKI 700
E+ ++++QDLL WV+E Q ++D EWG DLPSVE+ L +H+ +H++IEEF + ++ A+
Sbjct: 496 EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS 555
Query: 701 SEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE 760
E Q++ + Y + L RL+ QYAKLLN+S+ + R L++LH+FV+ AT EL+WLNEKEE
Sbjct: 556 DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE 615
Query: 761 EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR 820
EEV +DWS+RNTN+ KK+ ++ LMREL+ KE+ IK +Q ++LL E+HPAR T+E+++
Sbjct: 616 EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 675
Query: 821 AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSI 880
AA+QTQWSW+LQLC C+E H+KEN AYF+FF+D +EA L+ L++A++RKYSCDRS+++
Sbjct: 676 AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATV 735
Query: 881 HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ 940
+LEDL+Q++ +EKE+L +YK ++ L +AK ++QLKPR+ P++ +P+ A+CDY+Q
Sbjct: 736 TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 795
Query: 941 IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ 1000
+E+T++K DEC L + + WKV+S +G+EA VPSVCF VPPPN+EA + R+E Q+Q
Sbjct: 796 VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ 855
Query: 1001 NVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFL 1060
++TLWH+ H++MKS+++W L ++ IR+ ++A+ +T+ P E +Q L +L+ ++ FL
Sbjct: 856 ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 915
Query: 1061 EDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLE 1120
DSQ++ F D E+E C +YQ+LL+S E+ QEES ISE+++IRL+LE
Sbjct: 916 RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE 975
Query: 1121 NCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAAS 1180
CE R + ++R PL+++ E RI EQ+K + E+E L + ++ + E+ + S
Sbjct: 976 ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1035
Query: 1181 SSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEA 1240
+ PTLRSEL + L + QV S+S+ Y++KLKT++LV++ TQ AE +++ +E +L E +A
Sbjct: 1036 PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1095
Query: 1241 VIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWH 1300
V A +E ++LK+ R++ + ++ F AL DEL+ A+ + + + + + ERD++ +
Sbjct: 1096 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1155
Query: 1301 KEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQ 1360
+E+ QL+ERWQ V Q D R R+LE +G+ L+YYR++ PL W+Q Q +IQ
Sbjct: 1156 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1215
Query: 1361 PENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQ 1420
+S+ + QL Q++ L+ EIE K++ECQ++A+QY +KDYELQ +TY+A ++
Sbjct: 1216 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLE-PV 1274
Query: 1421 KSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKK 1480
SP K+ ++QS ++ +IQE++DLRT Y+ L TL +QYIKF ++L+R+EEEE+ E+++
Sbjct: 1275 ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRA 1334
Query: 1481 E------HVEKAKELQKWVSNISKTLK-DAEKAGKPPFSKQKISSEEISTKKEQLSEALQ 1533
E VE A E Q+ ++ K AE+ K Q+ EE+ ++E +A Q
Sbjct: 1335 EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAK---ELQQRMQEEVVRREEAAVDAQQ 1391
Query: 1534 TIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKI-V 1592
++ ++++++ L++S +Q + ++ S +++EE+I V
Sbjct: 1392 ----------------QKRSIQEELQQLRQSSEAEIQAKARQAEAAERS-RLRIEEEIRV 1434
Query: 1593 AERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQ--EELQKDMQGS 1650
Q E E+ +G + G +A E +K Q+++ E L++ +Q
Sbjct: 1435 VRLQLEATERQRGGAE----------GELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1484
Query: 1651 AQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVT 1710
+Q + + +K E ++ +AL Q L E +++ E+ + Q++ E + V
Sbjct: 1485 SQRKRQAEVELASRVKAEAEAAREKQRAL--QALEELRLQAEEAERRLRQAEVERARQVQ 1542
Query: 1711 TAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDG 1770
A+ ET + +A +L+ + L ++ A + ++ E+ Q+ +
Sbjct: 1543 VAL--ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ--QQAEA 1598
Query: 1771 KSAIGE-EDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQ 1829
+ A E E E+ L+ + ++ E + QQ +A+ EK + A+
Sbjct: 1599 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK----------QKEEAE 1648
Query: 1830 VLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEF 1889
++G+ EE+ Q+ + E ++ + LAE + +L + ++EL + A+ +
Sbjct: 1649 REARRRGK---AEEQAVRQRELAEQELEKQRQLAEGTAQQRL--AAEQELIRLRAETEQG 1703
Query: 1890 EHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAK 1949
E Q E+EL L+ A ++++ ++ + ++ + S R E ++
Sbjct: 1704 EQQRQLLEEELARLQREA------AAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1757
Query: 1950 SCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCG 2009
S S++ +++ A R+L R R+L + ++ D + +A
Sbjct: 1758 STSEKSKQRLEAEAGR---FRELAEEAARLRALAEEAKRQRQLAEE--DAARQRAEAERV 1812
Query: 2010 LLAGLQAC-EATASKHLSEPIAVDPKNLQ----RQLEETKALQGQISSQQVAVEKLKKTA 2064
L L A EAT K +E IA+ K + R+L E +A Q + +Q A K
Sbjct: 1813 LAEKLAAIGEATRLKTEAE-IALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHK----- 1866
Query: 2065 EVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEML 2124
D L + L+ G ED + + E++ L+++ ++
Sbjct: 1867 ---ADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEI-------LALKASFEKAA 1916
Query: 2125 DWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDP 2184
G E L E G++ N+ +D + E + A RQ + A E+ ++ E
Sbjct: 1917 --AGKAELEL-ELGRIRSNA---EDTLRSKEQAELE-AARQRQLAAEEERRRREAE---- 1965
Query: 2185 STASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALT 2244
+ K L+A EA+ + K L ++E LK KVE L E+ + + Q
Sbjct: 1966 ------ERVQKSLAAE-EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ 2018
Query: 2245 EVDVPGKDVTE------LSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLE 2298
E E + Q QE + + L+ L + +++A V +
Sbjct: 2019 EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARV-Q 2077
Query: 2299 KTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGA 2358
++ +++E+ + K+ A Q + A K K +E ++ Q +
Sbjct: 2078 AEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQ 2137
Query: 2359 EDLGKS-LEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLN 2417
+ + +E KK E+ + ++++ ++ L T K + + L
Sbjct: 2138 KQAADAEMEKHKKFAEQTLRQKAQVEQ----ELTTLRLQLEETDHQKNL--LDEELQRLK 2191
Query: 2418 GEGTATNTEEFWANKGLTSIKKDMTDISH-----GYEDLGLLLKDKIAELNTKLSKLQKA 2472
E T + + L S++ M ++S E+ L+L+DK NT+ +
Sbjct: 2192 AEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKD---NTQ----RFL 2244
Query: 2473 QEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQE---L 2529
QEE+ M Q ++ + + Q+ A A + +Q E LK+ + VQE L
Sbjct: 2245 QEEAEKMKQVAEEAARLSVAAQEA-ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2303
Query: 2530 KDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQ-TVE 2588
K + ELL++ + + ++ +L D++Q ++ + FQ T+E
Sbjct: 2304 KAE-AELLQQQKELAQ---------------EQARRLQEDKEQMAQQLAEETQGFQRTLE 2347
Query: 2589 AQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILS 2648
A+ ++ L ++ + +++++ + E + + + E+ +
Sbjct: 2348 AERQRQL------------------EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE 2389
Query: 2649 RPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSD 2708
GE + ++ + Q + Q + + +AI + + + L+
Sbjct: 2390 EIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ------- 2442
Query: 2709 LDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCED----LSALVKEE 2764
+ KL + Q L+ Q ++Q EK + + E L L ++E
Sbjct: 2443 -EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDE 2501
Query: 2765 YLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQN 2824
KA+ R+ + + + +EQ+ + V ++ A H+ ++ R Q L ++++
Sbjct: 2502 VAKAQQLREEQ--QRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRR 2559
Query: 2825 KSHPISA--------KLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLL 2868
+ + A +L +LE + S+ +TA KT+ G + L
Sbjct: 2560 QQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDAL 2611
Score = 565 bits (1456), Expect = e-160
Identities = 272/465 (58%), Positives = 368/465 (79%), Gaps = 4/465 (0%)
Query: 59 LDPA---ERAVLRIADERDKVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEV 115
+DP+ + + + DERD+VQKKTFTKW+N+HL+K ++H++DLYEDLRDGHNLISLLEV
Sbjct: 1 MDPSRAIQNEISSLKDERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEV 60
Query: 116 LSGDTLPREKGRMRFHRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIIL 175
LSGD+LPREKGRMRFH+LQNVQIALDYL+ RQVKLVNIRNDDI DGNPKLTLGLIWTIIL
Sbjct: 61 LSGDSLPREKGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIIL 120
Query: 176 HFQISDIHVTGESEDMSAKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRP 235
HFQISDI V+G+SEDM+AKE+LLLW+Q+ EGY G+RC+NFT+ WRDG+LFNAIIH+++P
Sbjct: 121 HFQISDIQVSGQSEDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKP 180
Query: 236 DLIDMNTVAVQSNLANLEHAFYVAEK-IGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAF 294
LIDMN V Q+NL NL+ AF VAE+ +GV RLLDPEDVDV PDEKS+ITYVSSLYDA
Sbjct: 181 LLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAM 240
Query: 295 PKVPEGGEGIGANDVEVKWIEYQNMVNYLIQWIRHHVTTMSERTFPNNPVELKALYNQYL 354
P+VP+ +G+ AN+++++W EY+ +V L+QW+RHH ER FP++ E++ L++Q+L
Sbjct: 241 PRVPDVQDGVRANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFL 300
Query: 355 QFKETEIPPKETEKSKIKRLYKLLEIWIEFGRIKLLQGYHPNDIEKEWGKLIIAMLEREK 414
+FKE E+P KE +K++ K +Y+ LE ++ G++K+ GYHP D+EKEWGKL +A+LEREK
Sbjct: 301 KFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREK 360
Query: 415 ALRPEVERLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYI 474
LR E ERLE LQ+I ++Q ++ +CE++L A LQSD + L +G Q E+ +
Sbjct: 361 QLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDL 420
Query: 475 LECENLLRQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNE 519
+ ++++R DVQ L DG++ Q +Q+ +RV +L + ++A+R E
Sbjct: 421 DKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTE 465
Score = 111 bits (277), Expect = 2e-23
Identities = 355/1874 (18%), Positives = 725/1874 (38%), Gaps = 306/1874 (16%)
Query: 2676 GQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQK 2735
G S + Q++ + Q +S + +L D+ +L + + H + E A++
Sbjct: 937 GSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARE 996
Query: 2736 MKQEI-QQEKKQIKVA---------QALCEDLSALVKEEYLKAELSRQLEGILKSFKDVE 2785
Q I +Q+K Q +V A E + AL + L +LE L + V
Sbjct: 997 CAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVR 1056
Query: 2786 QKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKD 2845
+ +++ L++ Q +A + KE Q + A L LE+ K
Sbjct: 1057 SLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQ----AVPATLPELEAT----KA 1108
Query: 2846 FSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQ----------------LNTIKTN 2889
K L AQ+ + T + L + +G+++ +LQ + +
Sbjct: 1109 SLKKLRAQAEAQQPTF---DALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLER 1165
Query: 2890 WDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFC--LDPAEGENS 2947
W Q R+ +L++ + Y+E + L W+ + E+I+ D
Sbjct: 1166 WQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQ 1225
Query: 2948 IAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSK 3007
+ + ++L +E+++H VE A ++ K
Sbjct: 1226 LRQEQALLEEIERHGEKVEECQRFAKQYINAI---------------------------K 1258
Query: 3008 KFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQA 3067
+ L+ +T K + S K ++Q E + I + + + + ++ T+ K +
Sbjct: 1259 DYELQLVTYKAQLEPVASPAKKPKVQSGSESV-IQEYVDLRTHYSELTTLTSQYIKFISE 1317
Query: 3068 LKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVET-IAQEHSTLSQQVDEKCSFLETKLQG 3126
+++ +RLA+ E + + L+ + +A+ H+ Q + + L+ ++Q
Sbjct: 1318 TLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ- 1376
Query: 3127 IGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKET-IKAFLKKLEALMASNDNA 3185
E+ + D + + + L++ E I+A ++ EA S
Sbjct: 1377 --------EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRI 1428
Query: 3186 NKTCKMM-LATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKL 3244
+ +++ L E T G + +L+AL +AR E+ E ++ +E +L
Sbjct: 1429 EEEIRVVRLQLEATERQRGGAEGELQAL-----------RARAEEAEAQKRQAQEEAERL 1477
Query: 3245 KEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLI 3304
+ + +ESQ E E ++ K E E + KQ+ + L + +
Sbjct: 1478 RR--------QVQDESQRKRQAEVELASRV--------KAEAEAAREKQRALQALEELRL 1521
Query: 3305 QSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVD 3364
Q+ + L + +RA Q+Q AL
Sbjct: 1522 QAEEAE-----------------RRLRQAEVERARQVQVAL------------------- 1545
Query: 3365 TEELVANQKPPSAEFKVVKAQIQEQKL-LQRLLDDRKSTVEVIKREGEKIATTAEPADKV 3423
Q+ AE + +A E+ L+R L + V ++ E E+ A A++
Sbjct: 1546 ----ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERA 1601
Query: 3424 KILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEP 3483
+ + L RW+ N+A Q E VAQQ + L + EK+ E
Sbjct: 1602 REEAEREL--ERWQLKANEALRLRLQAEE---VAQQ-----KSLAQ--AEAEKQKEEAER 1649
Query: 3484 IGTQASKLEEQIAQHKALEDDIINHNKHLHQAVS---IGQSLKVLSSREDKDMVQSKLDF 3540
+ K EEQ + + L + + + L + + + +++ R + + + +
Sbjct: 1650 EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL 1709
Query: 3541 SQVWYIEIQEKSHSRSELLQQALCN-AKIFGEDEVELMNWLN--EVHDKLSKLSVQDYST 3597
+ +Q ++ + ++ Q+ AK+ E EV L + E S+ S Q
Sbjct: 1710 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1769
Query: 3598 EG-----LWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKA 3652
E L ++ + LR L E+ ++Q ++ + +Q E ++ +KL AI
Sbjct: 1770 EAGRFRELAEEAARLRALAEEAKRQRQLAEE------DAARQRAEAE-RVLAEKLAAIG- 1821
Query: 3653 RYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQA 3712
+ T+L T+ L++ RL E+ ++E + ++ + E A
Sbjct: 1822 ---EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI----EERLA 1874
Query: 3713 QMRPKELKKEAKNNKALL-DSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTIT 3771
Q+R K E + K L+ D+L + E++ +A EK A E
Sbjct: 1875 QLR-KASDSELERQKGLVEDTLRQRRQVEEEILALKA--SFEKAAAGKAEL--------- 1922
Query: 3772 QKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTME 3831
E++ +RS D E + + ++ ++ + E+ + A+ +VQK+ E
Sbjct: 1923 ----ELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEE---ERRRREAEERVQKSLAAE 1975
Query: 3832 ---ILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLE- 3887
+ K ++++ + K+ EE + ++++ ++ + Q +++ LQ E
Sbjct: 1976 EEAARQRKAALEEVERLKAKV------EEARRLRERAEQESARQLQLAQEAAQKRLQAEE 2029
Query: 3888 RAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPH 3947
+A + Q E +EL L + QS++ QL A E R+ EE + R
Sbjct: 2030 KAHAFAVQQKE--QELQQTLQQEQSVLDQLRGEA---EAARRAAEEAEEARVQAEREAAQ 2084
Query: 3948 IDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQST----- 4002
+ + +L + + + + + AA+ L + +++ +RA A A+ Q
Sbjct: 2085 SRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAE 2144
Query: 4003 -QFHDK-----------IDQILESLE-RIVERLRQPPSISAEVEKIKEQISENK------ 4043
+ H K ++Q L +L ++ E Q + E++++K + +E
Sbjct: 2145 MEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQV 2204
Query: 4044 -----NVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHT 4098
+V V ME+L L ++ +I R DKD + + +Q++ ++M + E
Sbjct: 2205 EEELFSVRVQMEELSKLKARIEAENRALILR----DKDNTQRFLQEEAEKMKQVAEEAAR 2260
Query: 4099 L-VEEREAKLLDVMELAEKFWCDHMSLIVT-IKDTQDFIRDLEDPGIDPSVVKQQQEAAE 4156
L V +EA L +LAE+ +L +K+ +++ + +++QQ+E A+
Sbjct: 2261 LSVAAQEAARL--RQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ 2318
Query: 4157 TIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKL 4216
E+ LQE+ + ++ E + + E + +A + ++ ++
Sbjct: 2319 ---EQARRLQEDKE-------QMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKL-RV 2367
Query: 4217 EEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQI 4276
E +A + ++ Q + G KL + T+ Q +E I
Sbjct: 2368 AEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE-------------I 2414
Query: 4277 EMERLNHQAELLLKKVTE-ESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQ 4335
+ ++ +H AE L + + E E +K +Q E KL+ EE +Q +L AL Q
Sbjct: 2415 QRQQSDHDAERLREAIAELEREKEKLQQ---EAKLLQLKSEEMQTVQQEQLLQETQALQQ 2471
Query: 4336 FQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEI----ELAKHHVLQNDVLAHQSTVEAV 4391
++L+ + LL ++ + + +E E+AK L+ + Q +E
Sbjct: 2472 ---------SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQE 2522
Query: 4392 NKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIED 4451
+ L+ S EEA Q++ E +R Q L++ EQ+++Q + L + + + +
Sbjct: 2523 RQR---LVASM--EEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEE---NQRLRE 2574
Query: 4452 LQQWLTDTERHLLA 4465
Q L + R LA
Sbjct: 2575 QLQLLEEQHRAALA 2588
Score = 94.0 bits (232), Expect = 4e-18
Identities = 353/1847 (19%), Positives = 705/1847 (38%), Gaps = 283/1847 (15%)
Query: 3201 DLVGIKRDLEALSKQCNKLLDRAQ--AREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHE 3258
D + +R+ + S +LL + A+EE R + S+LK+ + L+ E
Sbjct: 928 DRLMAEREYGSCSHHYQQLLQSLEQGAQEES------RCQRCISELKDIRLQLEACETRT 981
Query: 3259 ESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAK--------- 3309
+ + ++ E + + I Q Q +V LG+G+ + +A+
Sbjct: 982 VHRLRLPLDKEPARECA--------QRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPE 1033
Query: 3310 -STSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEEL 3368
S + L +L+ + + + A +L+ L Q A E L + +E
Sbjct: 1034 PSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEA 1093
Query: 3369 VA------NQKPPSAEFKVVKAQIQ-EQKLLQRLLDDRKSTVEVIKREGEKIATTAEPAD 3421
A + A K ++AQ + +Q L D+ + EV +R ++ +
Sbjct: 1094 QAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVE 1153
Query: 3422 KVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNC 3481
+ + ++++ L RW+A+L + + R R+LE + + + E+ +PL WL +R
Sbjct: 1154 RWR--ERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQI 1211
Query: 3482 EPIGTQASK-LEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDF 3540
+ + S+ + EQ+ Q +AL ++I H + + + + + +V K
Sbjct: 1212 QAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQL 1271
Query: 3541 SQVWYIEIQEKSHSRSELLQQALCNAKI-FGEDEVELMNWLNEVHDKLSKLSVQDYSTEG 3599
V + K S SE + Q + + + E ++ + + L ++ ++ E
Sbjct: 1272 EPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE- 1330
Query: 3600 LWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITK 3659
+Q++E R R V+ AL +L + Q K +A + + +
Sbjct: 1331 --QQRAEERE-------RLAEVEAALEKQRQLAEAHA-------QAKAQAEREAKELQQR 1374
Query: 3660 LSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKEL 3719
+ +V + E A+ ++ S EEL E E+ + K +A A+ +
Sbjct: 1375 MQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQA------KARQAEAAERSRLRI 1428
Query: 3720 KKEAKNNKALLDSL-NEVSSALLELVPWRAR----EGLEKMVAEDNERYRLVSDTITQKV 3774
++E + + L++ + A EL RAR E ++ E+ ER R +Q+
Sbjct: 1429 EEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRK 1488
Query: 3775 EEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILR 3834
+ + + AE E ++ L +L ++RL+ ++ +L+ E+ R
Sbjct: 1489 RQAEV------ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR-----QAEVER 1537
Query: 3835 HKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVN 3894
+ V+ + +E E QS + +E+ QLER+
Sbjct: 1538 ARQ-----VQVALETAQRSAEAELQSKRASF--------------AEKTAQLERS----- 1573
Query: 3895 QFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKT 3954
L E ++QL E E QQQ E + RE E + +++
Sbjct: 1574 ------------LQEEHVAVAQLRE---EAERRAQQQAEAERARE---EAERELERWQLK 1615
Query: 3955 GPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILES 4014
+ L L Q+K +A Q KE+ ++ A +A Q+ + + +Q LE
Sbjct: 1616 ANEALRLRLQAEEVAQQKSLAQAEAEKQ-KEEAEREARRRGKAEEQAVRQRELAEQELEK 1674
Query: 4015 LERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTD 4074
++ E Q ++AE E I+ + + E+ + L E R + A +
Sbjct: 1675 QRQLAEGTAQ-QRLAAEQELIRLRAETEQG-----EQQRQLLEEELARLQREAAAATQKR 1728
Query: 4075 KDISAKAVQDKLDQMVFIWENIHTLVEER----------EAKLLDVMELAEKFWCDHMSL 4124
+++ A+ + + + V + E R EA+ ELAE+ +
Sbjct: 1729 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE-----AAR 1783
Query: 4125 IVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQE------ELDIVI---NL 4175
+ + + R L + +Q+ EA + E++ + E E +I +
Sbjct: 1784 LRALAEEAKRQRQL----AEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEA 1839
Query: 4176 GSELIAACGEPDKPIVKKSIDE--------LNSAWDSLNKAWKDRIDK----LEEAMQAA 4223
+E + E D+ ++ ++E + L KA +++ +E+ ++
Sbjct: 1840 ENERLRRLAE-DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQR 1898
Query: 4224 VQYQDGLQAV-FDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQ---IEME 4279
Q ++ + A+ + A GK +G + + +Q + EA +Q+ E E
Sbjct: 1899 RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE 1958
Query: 4280 RLNHQAELLLKK--VTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQ 4337
R +AE ++K EE + L E++ + +EE R+ + + L Q
Sbjct: 1959 RRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ 2018
Query: 4338 HALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAH-QSTVEAVNKAGN 4396
A + L +QK E EL + + VL + EA +A
Sbjct: 2019 EAAQKRLQAEEKAHAFAVQQK---------EQELQQTLQQEQSVLDQLRGEAEAARRAAE 2069
Query: 4397 DLIES--SAGEEASNLQNKLEVLNQRWQNVLEKTEQ-----------RKQQLDGALRQAK 4443
+ E+ A EA+ + ++E + Q+ E+ + RK+ A R+A+
Sbjct: 2070 EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQ 2129
Query: 4444 GFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEET--YKSLM 4501
+ Q + E+H ++ +T +++ V E+ EET K+L+
Sbjct: 2130 AEQAALRQKQAADAEMEKHKKFAE------QTLRQKAQVEQELTTLRLQLEETDHQKNLL 2183
Query: 4502 QKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNE---RKTKLE-EALNLAMEFHNS 4557
+ Q L K+ T + + ++E+ SV ++ E K ++E E L + ++
Sbjct: 2184 DEELQRL----KAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDN 2239
Query: 4558 LQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLK 4617
Q F+ +AE+ VA + L + + A E + + + E K
Sbjct: 2240 TQRFLQ--EEAEKMKQVAEEAAR-LSVAAQEAARLRQLAEEDLAQQRALAE--------K 2288
Query: 4618 YFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSL-DDARKRAKQFHEAWSKLMEWLEE 4676
+K V L + ++ + E+ R L +D + A+Q E LE
Sbjct: 2289 MLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA 2348
Query: 4677 SEKSLDSELEIANDPDKIKTQLAQ--------HKEFQKSLGAKHSVYDTTNRTGRSLKEK 4728
+ +LE++ + +++K ++A+ ++ Q+ + + +RT + +EK
Sbjct: 2349 ERQ---RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEK 2405
Query: 4729 TSLAD-----------DNLKLDDMLSELRDKWDTICG-------KSVERQNKLEEALLFS 4770
+L D +L + ++EL + + + KS E Q +E LL
Sbjct: 2406 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLL-- 2463
Query: 4771 GQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKR 4830
Q T ALQ +L + L ++ + + + L + A ++L + Q
Sbjct: 2464 -QETQALQQ--SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2520
Query: 4831 SARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLE 4890
R+ + S +++ + + +E R + + +LE RQ EE
Sbjct: 2521 QERQRLVASMEEARRRQHEAEEGVRRKQ-------EELQQLEQQRRQQEEL--------- 2564
Query: 4891 WLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKAT 4937
LAE Q LR + L+ L +QH+ + EE A AT
Sbjct: 2565 -LAEENQRLR---------EQLQLLEEQHRAALAHSEEVTASQVAAT 2601
Score = 85.1 bits (209), Expect = 2e-15
Identities = 295/1541 (19%), Positives = 608/1541 (39%), Gaps = 226/1541 (14%)
Query: 3708 EASQAQMRPKELKKEAKNNKALLDSLN-------EVSSAL--------LELVPWRAREGL 3752
EA++A + K+L+ +A+ + D+L EV L +E+ WR R
Sbjct: 1104 EATKASL--KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRER--- 1158
Query: 3753 EKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIR 3812
VA+ ER++ V + E++ + + + ++AD +W+ + ++ + +
Sbjct: 1159 ---VAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1215
Query: 3813 LEQDQT-SAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQ--SMKKKLDKVL 3869
L Q QL+ ++ EI RH + +++ + + + A + E Q + K +L+ V
Sbjct: 1216 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA 1275
Query: 3870 KNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQ 3929
+ + QS + Y +L +E ++ SQ ETLR+
Sbjct: 1276 SP------------AKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIK--FISETLRR 1321
Query: 3930 QQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKK 3989
+EE R + AE + + ++ + +L+ + + A L +++E+V +
Sbjct: 1322 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1381
Query: 3990 RAVALDEAISQSTQFHDKIDQILESLERIVE-RLRQPPSISAEVEKIKEQISENKNVSVD 4048
R A +A Q +++ Q+ +S E ++ + RQ + +I+E+I
Sbjct: 1382 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR-------- 1433
Query: 4049 MEKLQPLYETLKQRG----EEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEERE 4104
+ +LQ L T +QRG E R+ + + + Q++ +++ + +E +
Sbjct: 1434 VVRLQ-LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLR------RQVQDESQ 1486
Query: 4105 AKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIRE-EID 4163
K +ELA + + + ++ Q ++ LE+ + Q +EA +R+ E++
Sbjct: 1487 RKRQAEVELASRVKAEAEAA----REKQRALQALEELRL------QAEEAERRLRQAEVE 1536
Query: 4164 GLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWD-SLNKAWKDRIDKLEEAMQA 4222
++ + + E E + + S E + + SL + EEA +
Sbjct: 1537 RARQ-----VQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERR 1591
Query: 4223 AVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLN 4282
A Q + +A + A +L + ++ Q EE+ Q KS A Q E E+
Sbjct: 1592 AQQQAEAERAREE----AERELERWQLKANEALRLRLQAEEVAQQKSLA---QAEAEKQK 1644
Query: 4283 HQAELLLKKVTEESDKHTVQDPLMELKLIWD-SLEERIINRQHKLEGALLALG------- 4334
+AE ++ + ++ Q L E +L L E ++ E L+ L
Sbjct: 1645 EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1704
Query: 4335 QFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKA 4394
Q + L+E LA L ++++ + +E ELAK +LA ++ E +++
Sbjct: 1705 QQRQLLEEELARLQREAAAATQKR------QELEAELAKVRAEMEVLLASKARAEEESRS 1758
Query: 4395 GNDL----IESSAG------EEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKG 4444
++ +E+ AG EEA+ L+ E ++ Q E +++ + + L +
Sbjct: 1759 TSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLA 1818
Query: 4445 FHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKG 4504
GE L+ TE + + E E+L + AF+ + ++ K
Sbjct: 1819 AIGEATRLK-----TEAEIALKEK-----EAENERLR-RLAEDEAFQRRRLEEQAAQHKA 1867
Query: 4505 --QQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFI 4562
++ LA+ K++++ +++ VE L +R+ EE L L F +
Sbjct: 1868 DIEERLAQLRKASDSELERQKG-------LVEDTLRQRRQVEEEILALKASFEKAAAG-- 1918
Query: 4563 NWLTQAEQTLNVASRPSLILDTV-------LFQIDEHKVFANEVNSHREQIIELDKTGTH 4615
+AE L + S DT+ L + ++ A E RE + K+
Sbjct: 1919 ----KAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAA 1974
Query: 4616 LKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLE 4675
+ ++++ L + V+RL + R+RA+Q E+ +L E
Sbjct: 1975 EEEAARQRKAAL-------------EEVERLKAKVEEARRLRERAEQ--ESARQLQLAQE 2019
Query: 4676 ESEKSLDSELEIANDPDKIKTQLAQHKE--FQKSLGAKHSVYDTTNRTGRSLKEKTSLAD 4733
++K L +E +K Q KE Q++L + SV D + + A+
Sbjct: 2020 AAQKRLQAE-------EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE 2072
Query: 4734 D-NLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLA 4792
+ ++ + ++ R + VE +L+++ Q QA + L + Q A
Sbjct: 2073 EARVQAEREAAQSR--------RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2124
Query: 4793 E-----DQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVK 4847
+Q ++ HK F ++ ++ + V+ + R +E + + +
Sbjct: 2125 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2184
Query: 4848 VQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPD 4907
++Q L + L + Q EE L+ EAE ++
Sbjct: 2185 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSK-----LKARIEAEN----RALILR 2235
Query: 4908 DEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFE 4967
D+D + + + E MK++ E+ A L+ A + + D + RA E
Sbjct: 2236 DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED--------LAQQRALAE 2287
Query: 4968 EVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALI 5027
++L K+ Q + A L A+ ELL+ Q L + +++ Q EE +
Sbjct: 2288 KML---KEKMQAVQEA-TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGF- 2342
Query: 5028 AEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSG 5087
Q +E ++Q ++ + K R A+ S Q+ + A R R A +
Sbjct: 2343 ---QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA----EEDAQRFRKQAEEIGEKL 2395
Query: 5088 SQTQIETKNPRVNLLVSKWQQVWLLALERRR------KLNDALDRLEELREFANFDFDIW 5141
+T++ T+ K V L ++R++ +L +A+ LE +E + +
Sbjct: 2396 HRTELATQ--------EKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL 2447
Query: 5142 RKKYMRWMNHKKSRVMDFFRRIDK----DQDGKITRQEFID 5178
+ K ++ +++ + + + ++D + R+ FI+
Sbjct: 2448 QLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE 2488
Score = 78.6 bits (192), Expect = 2e-13
Identities = 352/1885 (18%), Positives = 731/1885 (38%), Gaps = 251/1885 (13%)
Query: 3336 QRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRL 3395
QR +L+++ L L+ LL+W+ + + V + + V+AQ+ + L +
Sbjct: 490 QRRPELEDSTLRY------LQDLLAWVEENQHRVDGAEW-GVDLPSVEAQLGSHRGLHQS 542
Query: 3396 LDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGI-S 3454
+++ ++ +E + + +++ PA + L LD ++ LLN ++ R R LE + S
Sbjct: 543 IEEFRAKIERARSDEGQLS----PATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHS 598
Query: 3455 VVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQ 3514
VA E + WL E+ V + + + + + + AL ++ K + +
Sbjct: 599 FVAAATKELM-----WLNEKEEEEVGFD-WSDRNTNMTAKKESYSALMRELELKEKKIKE 652
Query: 3515 AVSIGQSL--KVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGED 3572
+ G L + +R + Q+ L W +LQ C
Sbjct: 653 LQNAGDRLLREDHPARPTVESFQAALQTQWSW-------------MLQLCCC-------- 691
Query: 3573 EVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQ-ALLNGLEL 3631
E H K + Q +S + + + +L+ LQE L RK + D+ A + LE
Sbjct: 692 --------IEAHLKENAAYFQFFS--DVREAEGQLQKLQE-ALRRKYSCDRSATVTRLED 740
Query: 3632 LKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDK 3691
L Q DE +++L K + +AK + +QL R H H
Sbjct: 741 LLQDAQDE----KEQLNEYKGHL-------SGLAKRAKAVVQLKPR-HPAHPMRGRLPLL 788
Query: 3692 VEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVS-SALLELVPWRARE 3750
+ E V KG+E + + K L S +E + ++ LVP +E
Sbjct: 789 AVCDYKQVEVTVHKGDECQLVG------PAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQE 842
Query: 3751 GLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGD 3810
E + + + LV T+ ++ ++L Q + SW T + L
Sbjct: 843 AQEAVTRLEAQHQALV--TLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKP--- 897
Query: 3811 IRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLK 3870
EQ Q L+ L ++ + D +G E++ +++
Sbjct: 898 --EEQRQALHSLE---------LHYQAFLRDSQDAG-----GFGPEDRLMAEREYGSCSH 941
Query: 3871 NYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQ 3930
+Y + Q + + R Q +++ + +L T T + +L P
Sbjct: 942 HYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRT---VHRLRLPL--------D 990
Query: 3931 QEEHRQLRELIAEHKPHIDKMNKTGPQLLELS--PGEGFSIQEKYVAADTLYSQIKEDVK 3988
+E R+ + IAE + ++ G + LS + ++ E AA TL S+++ +
Sbjct: 991 KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLG 1050
Query: 3989 KRAVALDEAISQSTQFHDKIDQIL----------ESLERIVERLRQPPSISAEVEKIKEQ 4038
K L++ S S + +K+ I E L E+L++ ++ A + +++
Sbjct: 1051 K----LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEAT 1106
Query: 4039 ISENKNVSVDMEKLQPLYETLKQR-------GEEMIARSGGTDKDISAKAVQDKLDQMVF 4091
+ K + E QP ++ L+ GE + R G ++D+ + ++++ Q++
Sbjct: 1107 KASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHG--ERDVEVERWRERVAQLLE 1164
Query: 4092 IWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLED-PGIDPSVVKQ 4150
W+ + + R+ +L + + L ++D + ++ P D V++
Sbjct: 1165 RWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVRE 1224
Query: 4151 QQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIV--KKSID---------ELN 4199
Q + + EEI+ E+++ + I A + + +V K ++ ++
Sbjct: 1225 QLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQ 1284
Query: 4200 SAWDSLNKAWKDRIDKLEEAMQAAVQY----QDGLQAVFDWVDIAGGKLAS----MSPIG 4251
S +S+ + + D E QY + L+ + + +A + A ++ +
Sbjct: 1285 SGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVE 1344
Query: 4252 TDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKK---VTEESDKHTVQDPLMEL 4308
LE +Q E Q K++A ++ E+++ Q E++ ++ V + K ++Q+ L +L
Sbjct: 1345 AALEKQRQLAEAHAQAKAQAEREAKELQQ-RMQEEVVRREEAAVDAQQQKRSIQEELQQL 1403
Query: 4309 KLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIE 4368
+ S E I + + E A + + + + + L TE + GG ++
Sbjct: 1404 R---QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATE------RQRGGAEGELQ 1454
Query: 4369 IELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEE---ASNLQNKLEVLNQRWQNVL 4425
A+ + Q E + + D + E AS ++ + E ++ Q L
Sbjct: 1455 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREK-QRAL 1513
Query: 4426 EKTEQRKQQLDGALRQAKGFHGEIE---DLQQWLTDTERHL---LASKPLGGLPETAKEQ 4479
+ E+ + Q + A R+ + E+E +Q L +R L SK +TA+ +
Sbjct: 1514 QALEELRLQAEEAERRLR--QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE 1571
Query: 4480 LNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNE 4539
++ E A + +EE + Q+ + AR E E +L
Sbjct: 1572 RSLQEEHVAVAQLREEAERRAQQQAEAERAR--------------------EEAERELER 1611
Query: 4540 RKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEV 4599
+ K EAL L ++ Q +AE+ A R + Q + A +
Sbjct: 1612 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1671
Query: 4600 NSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKR 4659
+ Q+ E GT + + +Q+++ ++ + + + + + L R A ++
Sbjct: 1672 LEKQRQLAE----GTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK 1727
Query: 4660 AKQFHEAWSKL---MEWLEESEKSLDSELEIANDPDK--IKTQLAQHKEFQKSLGAKHSV 4714
++ +K+ ME L S+ + E ++ K ++ + + +E + ++
Sbjct: 1728 RQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRAL 1787
Query: 4715 YDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFT 4774
+ R R L E+ + A + + +L+E G++ + + E AL
Sbjct: 1788 AEEAKRQ-RQLAEEDA-ARQRAEAERVLAEKL----AAIGEATRLKTEAEIALKEKEAEN 1841
Query: 4775 DALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARE 4834
+ L+ L + + + E+Q D+ L KA EL ++ V+ R R+
Sbjct: 1842 ERLRRLAE-DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQ 1900
Query: 4835 L------IEGSRDDSSWVKVQMQ-ELS-TRWETVCALSISKQTRLEAALRQ---AEE--- 4880
+ ++ S + ++ K +++ EL R L +Q LEAA ++ AEE
Sbjct: 1901 VEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERR 1960
Query: 4881 FHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRA-ELNKATTM 4939
+ + LA E+ R ++ + L+ +++ + ++ E++ A +L A
Sbjct: 1961 RREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA 2020
Query: 4940 GDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQ----QRLASALAGLIAKQELLE 4995
L K ++ + +E+ +Q Q Q A A A +E E
Sbjct: 2021 AQKRLQ-------AEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2073
Query: 4996 A-LLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRR 5054
A + A + A++ ++ E + Q EE A+ Q E++ RK+ + + +R
Sbjct: 2074 ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL-RKEAEQEAA----RRA 2128
Query: 5055 AADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGS--------QTQIETKNPRVNLLVSKW 5106
A+ ++L+ D K+F +L + Q+E + + NLL +
Sbjct: 2129 QAEQAALRQK-QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEEL 2187
Query: 5107 QQVWLLALERRRKLNDALDRLEELR 5131
Q++ A E R+ + + L +R
Sbjct: 2188 QRLKAEATEAARQRSQVEEELFSVR 2212
Score = 69.3 bits (168), Expect = 1e-10
Identities = 208/1057 (19%), Positives = 422/1057 (39%), Gaps = 142/1057 (13%)
Query: 4258 KQQIEELKQFKSEAYQQQIEME-------RLNHQAELLLKKVTEESDKHTVQDPLMELKL 4310
K+ E Q +E + Q E+E RL+ +AE +L T++ EL+L
Sbjct: 991 KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRS---ELEL 1047
Query: 4311 IWDSLEE-RIINRQH--KLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAI 4367
LE+ R ++ + KL+ L + Q A + L A E L E + V +
Sbjct: 1048 TLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAH----EEQLKEAQAVPATLPEL 1103
Query: 4368 EIELAKHHVLQNDVLAHQSTVEAVN------KAGNDLIESSAGE---EASNLQNKLEVLN 4418
E A L+ A Q T +A+ + + ++ GE E + ++ L
Sbjct: 1104 EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLL 1163
Query: 4419 QRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTER--HLLASKPLGGLPETA 4476
+RWQ VL +T+ R+++L+ RQ + + + L WL D R + + PL +
Sbjct: 1164 ERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLAD-SQAV 1222
Query: 4477 KEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETK 4536
+EQL +E+ +++ + + C + A+ Q IN +K+ E +
Sbjct: 1223 REQLR-----------QEQALLEEIERHGEKVEECQRFAK----QYINAIKD----YELQ 1263
Query: 4537 LNERKTKLEEALNLAME------FHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQID 4590
L K +LE + A + + +Q++++ T + + S+ + L +++
Sbjct: 1264 LVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRME 1323
Query: 4591 EHKVFAN-----------EVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRW 4639
E + A EV + E+ +L + K ++++ L + + V R
Sbjct: 1324 EEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRRE 1383
Query: 4640 EKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLA 4699
E V ++ RS+ + ++ +Q EA ++ ++E + S L I + ++ QL
Sbjct: 1384 EAAVDAQQQK-RSIQEELQQLRQSSEA--EIQAKARQAEAAERSRLRIEEEIRVVRLQL- 1439
Query: 4700 QHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVER 4759
+ E Q+ GA+ + R + +K ++ + + +++D+ VE
Sbjct: 1440 EATERQRG-GAEGELQALRARAEEAEAQKRQAQEE---AERLRRQVQDESQRKRQAEVEL 1495
Query: 4760 QNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDID----LVMNLIDNHKAFQ 4815
++++ + + ALQAL + R++ + AE + +++ + + L ++ +
Sbjct: 1496 ASRVKAEAEAAREKQRALQALEE--LRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1553
Query: 4816 KELGKRTSS----VQALKRSARE---LIEGSRDDSSWVKVQMQELS----------TRWE 4858
EL + +S L+RS +E + R+++ Q E RW+
Sbjct: 1554 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ 1613
Query: 4859 TVCALSISKQTRLEAALRQAEEFHSVVHALLE-WLAEAEQTLRFHGVLPDDEDALRTLID 4917
L ++ RL + + S+ A E EAE+ R G + R L +
Sbjct: 1614 ----LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAE 1669
Query: 4918 QHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQ 4977
Q E ++L E A+ A + + + + + AR + A A Q +
Sbjct: 1670 QELEKQRQLAEGTAQQRLAAEQ-ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKR 1728
Query: 4978 QRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEM 5037
Q L + LA + A+ E+L A A + + ++K K+ + E + L EE
Sbjct: 1729 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL-------AEEA 1781
Query: 5038 TRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETKNP 5097
R + ++ K ++ A + ++ Q RA +R A L G T+++T+
Sbjct: 1782 ARLRALAEE-AKRQRQLAEEDAARQ---------RAEAERVLAEKLAAIGEATRLKTEAE 1831
Query: 5098 RVNLLVSKWQQVWLLALERRRKLNDALDRLEELREFANFDFDIWRKKYMRWMNHKKSRVM 5157
+AL+ + N+ L RL E F R++ K+ +
Sbjct: 1832 --------------IALKEKEAENERLRRLAEDEAFQ-------RRRLEEQAAQHKADIE 1870
Query: 5158 DFFRRIDKDQDGKITRQE-FIDGILSSKFPTSRLEMSAVADIFDRDGDGYIDYYEFVAAL 5216
+ ++ K D ++ RQ+ ++ L + E+ A+ F++ G + + +
Sbjct: 1871 ERLAQLRKASDSELERQKGLVEDTLRQRRQVEE-EILALKASFEKAAAGKAELELELGRI 1929
Query: 5217 HPNKDAYKPITDADKIEDEVTRQVAKCKCAKRFQVEQ 5253
N + + ++E RQ+A + +R + E+
Sbjct: 1930 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEE 1966
Score = 40.0 bits (92), Expect = 0.064
Identities = 84/510 (16%), Positives = 207/510 (40%), Gaps = 52/510 (10%)
Query: 1078 EKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQI-RTPLER 1136
+ E+ K++ ++ L+ + EQE + L + E + + L+ RL + +R
Sbjct: 2142 DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR 2201
Query: 1137 DDLHESVFRITEQ----EKLKKELER----------------LKDDLGTITNKCEEFFSQ 1176
+ E +F + Q KLK +E L+++ + EE
Sbjct: 2202 SQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARL 2261
Query: 1177 AAASSSVPTLRSELNVVLQNMNQVYSMSSTYI-DKLKTVNLVLKNTQAAEALVKLYETKL 1235
+ A+ LR + +++ Q +++ + +K++ V + AE L + E
Sbjct: 2262 SVAAQEAARLRQ---LAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ 2318
Query: 1236 CEEEAVIADKNNI-ENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERD 1294
+ + DK + + L + ++ ++ +RQ + E ++ K EM + +
Sbjct: 2319 EQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAE 2378
Query: 1295 LDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQR 1354
D +++A+++ E+ + ++ ++ + + L + I ++E +
Sbjct: 2379 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKE 2438
Query: 1355 KIQ-ENQPENSKTLATQLNQQKMLVSEIE-MKQSKMDEC------QKYAEQYSATVKD-Y 1405
K+Q E + K+ Q QQ+ L+ E + ++QS + E +++ EQ A ++ +
Sbjct: 2439 KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLF 2498
Query: 1406 ELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRY--------------TALV 1451
+ + + + + QQ+ ++++M+ ++ + R R L
Sbjct: 2499 QDEVAKAQQLREEQQR---QQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE 2555
Query: 1452 TLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPF 1511
Q + + +RL E+ + LEE+ + + ++E+ +KTL + A P
Sbjct: 2556 QQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPA 2615
Query: 1512 SKQKISSEEISTKKEQLSEALQTIQLFLAK 1541
++ + +++ ++ LQ + A+
Sbjct: 2616 AEAEPEHSFDGLRRKVSAQRLQEAGILSAE 2645
Score = 35.0 bits (79), Expect = 2.1
Identities = 73/348 (20%), Positives = 135/348 (38%), Gaps = 54/348 (15%)
Query: 4633 ISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLM-------EWLEESEKSLDSEL 4685
+ V+ W K+ ++ER + L +R + +KL E L +++ L S++
Sbjct: 342 LDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDV 401
Query: 4686 -------------EIANDPDKIKTQLAQ-HKEFQKSLGAKHSVYDTTNRTGRSLKEKTSL 4731
E+ D DK + + + Q +H + R L E+
Sbjct: 402 RLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVA 461
Query: 4732 --ADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEP 4789
+ NL+L ++ + + +SV+R+ +LE++ L LQ L+ W+ E
Sbjct: 462 IRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTL------RYLQDLLAWVE--EN 513
Query: 4790 QLAEDQPVHG-DIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSR----DDSS 4844
Q D G D+ V + +H+ + + + + ++ + +L +R D
Sbjct: 514 QHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLG 573
Query: 4845 WVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHAL---LEWLAEAEQTLRF 4901
+ +Q +L L+ SK A LR E HS V A L WL E E+
Sbjct: 574 RLDLQYAKL---------LNSSK-----ARLRSLESLHSFVAAATKELMWLNEKEEE-EV 618
Query: 4902 HGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHP 4949
D + + + M++LE K ++ + GD +L HP
Sbjct: 619 GFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHP 666
Score = 35.0 bits (79), Expect = 2.1
Identities = 22/51 (43%), Positives = 26/51 (50%)
Query: 5433 EDSGLITTAAARVRTQFADSKKTPSRPGSRAGSKAGSRASSRRGSDASDFD 5483
E +GL AA T+ S + S GS AGS+ GSR SR GS FD
Sbjct: 4435 EGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTGSRTGSRAGSRRGSFD 4485
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 861 bits (2224), Expect = 0.0
Identities = 637/2272 (28%), Positives = 1151/2272 (50%), Gaps = 200/2272 (8%)
Query: 641 EEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKI 700
E+ ++++QDLL WV+E Q ++D EWG DLPSVE+ L +H+ +H++IEEF + ++ A+
Sbjct: 504 EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS 563
Query: 701 SEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE 760
E Q++ + Y + L RL+ QYAKLLN+S+ + R L++LH+FV+ AT EL+WLNEKEE
Sbjct: 564 DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE 623
Query: 761 EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR 820
EEV +DWS+RNTN+ KK+ ++ LMREL+ KE+ IK +Q ++LL E+HPAR T+E+++
Sbjct: 624 EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 683
Query: 821 AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSI 880
AA+QTQWSW+LQLC C+E H+KEN AYF+FF+D +EA L+ L++A++RKYSCDRS+++
Sbjct: 684 AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATV 743
Query: 881 HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ 940
+LEDL+Q++ +EKE+L +YK ++ L +AK ++QLKPR+ P++ +P+ A+CDY+Q
Sbjct: 744 TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 803
Query: 941 IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ 1000
+E+T++K DEC L + + WKV+S +G+EA VPSVCF VPPPN+EA + R+E Q+Q
Sbjct: 804 VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ 863
Query: 1001 NVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFL 1060
++TLWH+ H++MKS+++W L ++ IR+ ++A+ +T+ P E +Q L +L+ ++ FL
Sbjct: 864 ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 923
Query: 1061 EDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLE 1120
DSQ++ F D E+E C +YQ+LL+S E+ QEES ISE+++IRL+LE
Sbjct: 924 RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE 983
Query: 1121 NCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAAS 1180
CE R + ++R PL+++ E RI EQ+K + E+E L + ++ + E+ + S
Sbjct: 984 ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1043
Query: 1181 SSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEA 1240
+ PTLRSEL + L + QV S+S+ Y++KLKT++LV++ TQ AE +++ +E +L E +A
Sbjct: 1044 PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1103
Query: 1241 VIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWH 1300
V A +E ++LK+ R++ + ++ F AL DEL+ A+ + + + + + ERD++ +
Sbjct: 1104 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1163
Query: 1301 KEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQ 1360
+E+ QL+ERWQ V Q D R R+LE +G+ L+YYR++ PL W+Q Q +IQ
Sbjct: 1164 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1223
Query: 1361 PENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQ 1420
+S+ + QL Q++ L+ EIE K++ECQ++A+QY +KDYELQ +TY+A ++
Sbjct: 1224 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLE-PV 1282
Query: 1421 KSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKK 1480
SP K+ ++QS ++ +IQE++DLRT Y+ L TL +QYIKF ++L+R+EEEE+ E+++
Sbjct: 1283 ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRA 1342
Query: 1481 E------HVEKAKELQKWVSNISKTLK-DAEKAGKPPFSKQKISSEEISTKKEQLSEALQ 1533
E VE A E Q+ ++ K AE+ K Q+ EE+ ++E +A Q
Sbjct: 1343 EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAK---ELQQRMQEEVVRREEAAVDAQQ 1399
Query: 1534 TIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKI-V 1592
++ ++++++ L++S +Q + ++ S +++EE+I V
Sbjct: 1400 ----------------QKRSIQEELQQLRQSSEAEIQAKARQAEAAERS-RLRIEEEIRV 1442
Query: 1593 AERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQ--EELQKDMQGS 1650
Q E E+ +G + G +A E +K Q+++ E L++ +Q
Sbjct: 1443 VRLQLEATERQRGGAE----------GELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1492
Query: 1651 AQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVT 1710
+Q + + +K E ++ +AL Q L E +++ E+ + Q++ E + V
Sbjct: 1493 SQRKRQAEVELASRVKAEAEAAREKQRAL--QALEELRLQAEEAERRLRQAEVERARQVQ 1550
Query: 1711 TAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDG 1770
A+ ET + +A +L+ + L ++ A + ++ E+ Q+ +
Sbjct: 1551 VAL--ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ--QQAEA 1606
Query: 1771 KSAIGE-EDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQ 1829
+ A E E E+ L+ + ++ E + QQ +A+ EK + A+
Sbjct: 1607 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK----------QKEEAE 1656
Query: 1830 VLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEF 1889
++G+ EE+ Q+ + E ++ + LAE + +L + ++EL + A+ +
Sbjct: 1657 REARRRGK---AEEQAVRQRELAEQELEKQRQLAEGTAQQRL--AAEQELIRLRAETEQG 1711
Query: 1890 EHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAK 1949
E Q E+EL L+ A ++++ ++ + ++ + S R E ++
Sbjct: 1712 EQQRQLLEEELARLQREA------AAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1765
Query: 1950 SCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCG 2009
S S++ +++ A R+L R R+L + ++ D + +A
Sbjct: 1766 STSEKSKQRLEAEAGR---FRELAEEAARLRALAEEAKRQRQLAEE--DAARQRAEAERV 1820
Query: 2010 LLAGLQAC-EATASKHLSEPIAVDPKNLQ----RQLEETKALQGQISSQQVAVEKLKKTA 2064
L L A EAT K +E IA+ K + R+L E +A Q + +Q A K
Sbjct: 1821 LAEKLAAIGEATRLKTEAE-IALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHK----- 1874
Query: 2065 EVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEML 2124
D L + L+ G ED + + E++ L+++ ++
Sbjct: 1875 ---ADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEI-------LALKASFEKAA 1924
Query: 2125 DWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDP 2184
G E L E G++ N+ +D + E + A RQ + A E+ ++ E
Sbjct: 1925 --AGKAELEL-ELGRIRSNA---EDTLRSKEQAELE-AARQRQLAAEEERRRREAE---- 1973
Query: 2185 STASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALT 2244
+ K L+A EA+ + K L ++E LK KVE L E+ + + Q
Sbjct: 1974 ------ERVQKSLAAE-EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ 2026
Query: 2245 EVDVPGKDVTE------LSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLE 2298
E E + Q QE + + L+ L + +++A V +
Sbjct: 2027 EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARV-Q 2085
Query: 2299 KTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGA 2358
++ +++E+ + K+ A Q + A K K +E ++ Q +
Sbjct: 2086 AEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQ 2145
Query: 2359 EDLGKS-LEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLN 2417
+ + +E KK E+ + ++++ ++ L T K + + L
Sbjct: 2146 KQAADAEMEKHKKFAEQTLRQKAQVEQ----ELTTLRLQLEETDHQKNL--LDEELQRLK 2199
Query: 2418 GEGTATNTEEFWANKGLTSIKKDMTDISH-----GYEDLGLLLKDKIAELNTKLSKLQKA 2472
E T + + L S++ M ++S E+ L+L+DK NT+ +
Sbjct: 2200 AEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKD---NTQ----RFL 2252
Query: 2473 QEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQE---L 2529
QEE+ M Q ++ + + Q+ A A + +Q E LK+ + VQE L
Sbjct: 2253 QEEAEKMKQVAEEAARLSVAAQEA-ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2311
Query: 2530 KDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQ-TVE 2588
K + ELL++ + + ++ +L D++Q ++ + FQ T+E
Sbjct: 2312 KAE-AELLQQQKELAQ---------------EQARRLQEDKEQMAQQLAEETQGFQRTLE 2355
Query: 2589 AQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILS 2648
A+ ++ L ++ + +++++ + E + + + E+ +
Sbjct: 2356 AERQRQL------------------EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE 2397
Query: 2649 RPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSD 2708
GE + ++ + Q + Q + + +AI + + + L+
Sbjct: 2398 EIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ------- 2450
Query: 2709 LDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCED----LSALVKEE 2764
+ KL + Q L+ Q ++Q EK + + E L L ++E
Sbjct: 2451 -EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDE 2509
Query: 2765 YLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQN 2824
KA+ R+ + + + +EQ+ + V ++ A H+ ++ R Q L ++++
Sbjct: 2510 VAKAQQLREEQ--QRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRR 2567
Query: 2825 KSHPISA--------KLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLL 2868
+ + A +L +LE + S+ +TA KT+ G + L
Sbjct: 2568 QQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDAL 2619
Score = 563 bits (1452), Expect = e-159
Identities = 270/450 (60%), Positives = 361/450 (80%), Gaps = 1/450 (0%)
Query: 71 DERDKVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEVLSGDTLPREKGRMRF 130
DERD+VQKKTFTKW+N+HL+K ++H++DLYEDLRDGHNLISLLEVLSGD+LPREKGRMRF
Sbjct: 24 DERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRF 83
Query: 131 HRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIHVTGESED 190
H+LQNVQIALDYL+ RQVKLVNIRNDDI DGNPKLTLGLIWTIILHFQISDI V+G+SED
Sbjct: 84 HKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSED 143
Query: 191 MSAKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAVQSNLA 250
M+AKE+LLLW+Q+ EGY G+RC+NFT+ WRDG+LFNAIIH+++P LIDMN V Q+NL
Sbjct: 144 MTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLE 203
Query: 251 NLEHAFYVAEK-IGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAFPKVPEGGEGIGANDV 309
NL+ AF VAE+ +GV RLLDPEDVDV PDEKS+ITYVSSLYDA P+VP+ +G+ AN++
Sbjct: 204 NLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANEL 263
Query: 310 EVKWIEYQNMVNYLIQWIRHHVTTMSERTFPNNPVELKALYNQYLQFKETEIPPKETEKS 369
+++W EY+ +V L+QW+RHH ER FP++ E++ L++Q+L+FKE E+P KE +K+
Sbjct: 264 QLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKN 323
Query: 370 KIKRLYKLLEIWIEFGRIKLLQGYHPNDIEKEWGKLIIAMLEREKALRPEVERLEMLQQI 429
+ K +Y+ LE ++ G++K+ GYHP D+EKEWGKL +A+LEREK LR E ERLE LQ+I
Sbjct: 324 RSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRI 383
Query: 430 ANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLLRQHVIDVQ 489
++Q ++ +CE++L A LQSD + L +G Q E+ + + ++++R DVQ
Sbjct: 384 VTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQ 443
Query: 490 ILIDGKYYQADQLVQRVAKLRDEIMALRNE 519
L DG++ Q +Q+ +RV +L + ++A+R E
Sbjct: 444 TLKDGRHPQGEQMYRRVYRLHERLVAIRTE 473
Score = 111 bits (277), Expect = 2e-23
Identities = 355/1874 (18%), Positives = 725/1874 (38%), Gaps = 306/1874 (16%)
Query: 2676 GQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQK 2735
G S + Q++ + Q +S + +L D+ +L + + H + E A++
Sbjct: 945 GSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARE 1004
Query: 2736 MKQEI-QQEKKQIKVA---------QALCEDLSALVKEEYLKAELSRQLEGILKSFKDVE 2785
Q I +Q+K Q +V A E + AL + L +LE L + V
Sbjct: 1005 CAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVR 1064
Query: 2786 QKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKD 2845
+ +++ L++ Q +A + KE Q + A L LE+ K
Sbjct: 1065 SLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQ----AVPATLPELEAT----KA 1116
Query: 2846 FSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQ----------------LNTIKTN 2889
K L AQ+ + T + L + +G+++ +LQ + +
Sbjct: 1117 SLKKLRAQAEAQQPTF---DALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLER 1173
Query: 2890 WDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFC--LDPAEGENS 2947
W Q R+ +L++ + Y+E + L W+ + E+I+ D
Sbjct: 1174 WQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQ 1233
Query: 2948 IAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSK 3007
+ + ++L +E+++H VE A ++ K
Sbjct: 1234 LRQEQALLEEIERHGEKVEECQRFAKQYINAI---------------------------K 1266
Query: 3008 KFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQA 3067
+ L+ +T K + S K ++Q E + I + + + + ++ T+ K +
Sbjct: 1267 DYELQLVTYKAQLEPVASPAKKPKVQSGSESV-IQEYVDLRTHYSELTTLTSQYIKFISE 1325
Query: 3068 LKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVET-IAQEHSTLSQQVDEKCSFLETKLQG 3126
+++ +RLA+ E + + L+ + +A+ H+ Q + + L+ ++Q
Sbjct: 1326 TLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ- 1384
Query: 3127 IGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKET-IKAFLKKLEALMASNDNA 3185
E+ + D + + + L++ E I+A ++ EA S
Sbjct: 1385 --------EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRI 1436
Query: 3186 NKTCKMM-LATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKL 3244
+ +++ L E T G + +L+AL +AR E+ E ++ +E +L
Sbjct: 1437 EEEIRVVRLQLEATERQRGGAEGELQAL-----------RARAEEAEAQKRQAQEEAERL 1485
Query: 3245 KEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLI 3304
+ + +ESQ E E ++ K E E + KQ+ + L + +
Sbjct: 1486 RR--------QVQDESQRKRQAEVELASRV--------KAEAEAAREKQRALQALEELRL 1529
Query: 3305 QSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVD 3364
Q+ + L + +RA Q+Q AL
Sbjct: 1530 QAEEAE-----------------RRLRQAEVERARQVQVAL------------------- 1553
Query: 3365 TEELVANQKPPSAEFKVVKAQIQEQKL-LQRLLDDRKSTVEVIKREGEKIATTAEPADKV 3423
Q+ AE + +A E+ L+R L + V ++ E E+ A A++
Sbjct: 1554 ----ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERA 1609
Query: 3424 KILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEP 3483
+ + L RW+ N+A Q E VAQQ + L + EK+ E
Sbjct: 1610 REEAEREL--ERWQLKANEALRLRLQAEE---VAQQ-----KSLAQ--AEAEKQKEEAER 1657
Query: 3484 IGTQASKLEEQIAQHKALEDDIINHNKHLHQAVS---IGQSLKVLSSREDKDMVQSKLDF 3540
+ K EEQ + + L + + + L + + + +++ R + + + +
Sbjct: 1658 EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL 1717
Query: 3541 SQVWYIEIQEKSHSRSELLQQALCN-AKIFGEDEVELMNWLN--EVHDKLSKLSVQDYST 3597
+ +Q ++ + ++ Q+ AK+ E EV L + E S+ S Q
Sbjct: 1718 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1777
Query: 3598 EG-----LWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKA 3652
E L ++ + LR L E+ ++Q ++ + +Q E ++ +KL AI
Sbjct: 1778 EAGRFRELAEEAARLRALAEEAKRQRQLAEE------DAARQRAEAE-RVLAEKLAAIG- 1829
Query: 3653 RYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQA 3712
+ T+L T+ L++ RL E+ ++E + ++ + E A
Sbjct: 1830 ---EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI----EERLA 1882
Query: 3713 QMRPKELKKEAKNNKALL-DSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTIT 3771
Q+R K E + K L+ D+L + E++ +A EK A E
Sbjct: 1883 QLR-KASDSELERQKGLVEDTLRQRRQVEEEILALKA--SFEKAAAGKAEL--------- 1930
Query: 3772 QKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTME 3831
E++ +RS D E + + ++ ++ + E+ + A+ +VQK+ E
Sbjct: 1931 ----ELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEE---ERRRREAEERVQKSLAAE 1983
Query: 3832 ---ILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLE- 3887
+ K ++++ + K+ EE + ++++ ++ + Q +++ LQ E
Sbjct: 1984 EEAARQRKAALEEVERLKAKV------EEARRLRERAEQESARQLQLAQEAAQKRLQAEE 2037
Query: 3888 RAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPH 3947
+A + Q E +EL L + QS++ QL A E R+ EE + R
Sbjct: 2038 KAHAFAVQQKE--QELQQTLQQEQSVLDQLRGEA---EAARRAAEEAEEARVQAEREAAQ 2092
Query: 3948 IDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQST----- 4002
+ + +L + + + + + AA+ L + +++ +RA A A+ Q
Sbjct: 2093 SRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAE 2152
Query: 4003 -QFHDK-----------IDQILESLE-RIVERLRQPPSISAEVEKIKEQISENK------ 4043
+ H K ++Q L +L ++ E Q + E++++K + +E
Sbjct: 2153 MEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQV 2212
Query: 4044 -----NVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHT 4098
+V V ME+L L ++ +I R DKD + + +Q++ ++M + E
Sbjct: 2213 EEELFSVRVQMEELSKLKARIEAENRALILR----DKDNTQRFLQEEAEKMKQVAEEAAR 2268
Query: 4099 L-VEEREAKLLDVMELAEKFWCDHMSLIVT-IKDTQDFIRDLEDPGIDPSVVKQQQEAAE 4156
L V +EA L +LAE+ +L +K+ +++ + +++QQ+E A+
Sbjct: 2269 LSVAAQEAARL--RQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ 2326
Query: 4157 TIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKL 4216
E+ LQE+ + ++ E + + E + +A + ++ ++
Sbjct: 2327 ---EQARRLQEDKE-------QMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKL-RV 2375
Query: 4217 EEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQI 4276
E +A + ++ Q + G KL + T+ Q +E I
Sbjct: 2376 AEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE-------------I 2422
Query: 4277 EMERLNHQAELLLKKVTE-ESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQ 4335
+ ++ +H AE L + + E E +K +Q E KL+ EE +Q +L AL Q
Sbjct: 2423 QRQQSDHDAERLREAIAELEREKEKLQQ---EAKLLQLKSEEMQTVQQEQLLQETQALQQ 2479
Query: 4336 FQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEI----ELAKHHVLQNDVLAHQSTVEAV 4391
++L+ + LL ++ + + +E E+AK L+ + Q +E
Sbjct: 2480 ---------SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQE 2530
Query: 4392 NKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIED 4451
+ L+ S EEA Q++ E +R Q L++ EQ+++Q + L + + + +
Sbjct: 2531 RQR---LVASM--EEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEE---NQRLRE 2582
Query: 4452 LQQWLTDTERHLLA 4465
Q L + R LA
Sbjct: 2583 QLQLLEEQHRAALA 2596
Score = 94.0 bits (232), Expect = 4e-18
Identities = 353/1847 (19%), Positives = 705/1847 (38%), Gaps = 283/1847 (15%)
Query: 3201 DLVGIKRDLEALSKQCNKLLDRAQ--AREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHE 3258
D + +R+ + S +LL + A+EE R + S+LK+ + L+ E
Sbjct: 936 DRLMAEREYGSCSHHYQQLLQSLEQGAQEES------RCQRCISELKDIRLQLEACETRT 989
Query: 3259 ESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAK--------- 3309
+ + ++ E + + I Q Q +V LG+G+ + +A+
Sbjct: 990 VHRLRLPLDKEPARECA--------QRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPE 1041
Query: 3310 -STSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEEL 3368
S + L +L+ + + + A +L+ L Q A E L + +E
Sbjct: 1042 PSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEA 1101
Query: 3369 VA------NQKPPSAEFKVVKAQIQ-EQKLLQRLLDDRKSTVEVIKREGEKIATTAEPAD 3421
A + A K ++AQ + +Q L D+ + EV +R ++ +
Sbjct: 1102 QAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVE 1161
Query: 3422 KVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNC 3481
+ + ++++ L RW+A+L + + R R+LE + + + E+ +PL WL +R
Sbjct: 1162 RWR--ERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQI 1219
Query: 3482 EPIGTQASK-LEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDF 3540
+ + S+ + EQ+ Q +AL ++I H + + + + + +V K
Sbjct: 1220 QAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQL 1279
Query: 3541 SQVWYIEIQEKSHSRSELLQQALCNAKI-FGEDEVELMNWLNEVHDKLSKLSVQDYSTEG 3599
V + K S SE + Q + + + E ++ + + L ++ ++ E
Sbjct: 1280 EPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE- 1338
Query: 3600 LWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITK 3659
+Q++E R R V+ AL +L + Q K +A + + +
Sbjct: 1339 --QQRAEERE-------RLAEVEAALEKQRQLAEAHA-------QAKAQAEREAKELQQR 1382
Query: 3660 LSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKEL 3719
+ +V + E A+ ++ S EEL E E+ + K +A A+ +
Sbjct: 1383 MQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQA------KARQAEAAERSRLRI 1436
Query: 3720 KKEAKNNKALLDSL-NEVSSALLELVPWRAR----EGLEKMVAEDNERYRLVSDTITQKV 3774
++E + + L++ + A EL RAR E ++ E+ ER R +Q+
Sbjct: 1437 EEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRK 1496
Query: 3775 EEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILR 3834
+ + + AE E ++ L +L ++RL+ ++ +L+ E+ R
Sbjct: 1497 RQAEV------ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR-----QAEVER 1545
Query: 3835 HKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVN 3894
+ V+ + +E E QS + +E+ QLER+
Sbjct: 1546 ARQ-----VQVALETAQRSAEAELQSKRASF--------------AEKTAQLERS----- 1581
Query: 3895 QFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKT 3954
L E ++QL E E QQQ E + RE E + +++
Sbjct: 1582 ------------LQEEHVAVAQLRE---EAERRAQQQAEAERARE---EAERELERWQLK 1623
Query: 3955 GPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILES 4014
+ L L Q+K +A Q KE+ ++ A +A Q+ + + +Q LE
Sbjct: 1624 ANEALRLRLQAEEVAQQKSLAQAEAEKQ-KEEAEREARRRGKAEEQAVRQRELAEQELEK 1682
Query: 4015 LERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTD 4074
++ E Q ++AE E I+ + + E+ + L E R + A +
Sbjct: 1683 QRQLAEGTAQ-QRLAAEQELIRLRAETEQG-----EQQRQLLEEELARLQREAAAATQKR 1736
Query: 4075 KDISAKAVQDKLDQMVFIWENIHTLVEER----------EAKLLDVMELAEKFWCDHMSL 4124
+++ A+ + + + V + E R EA+ ELAE+ +
Sbjct: 1737 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE-----AAR 1791
Query: 4125 IVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQE------ELDIVI---NL 4175
+ + + R L + +Q+ EA + E++ + E E +I +
Sbjct: 1792 LRALAEEAKRQRQL----AEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEA 1847
Query: 4176 GSELIAACGEPDKPIVKKSIDE--------LNSAWDSLNKAWKDRIDK----LEEAMQAA 4223
+E + E D+ ++ ++E + L KA +++ +E+ ++
Sbjct: 1848 ENERLRRLAE-DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQR 1906
Query: 4224 VQYQDGLQAV-FDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQ---IEME 4279
Q ++ + A+ + A GK +G + + +Q + EA +Q+ E E
Sbjct: 1907 RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE 1966
Query: 4280 RLNHQAELLLKK--VTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQ 4337
R +AE ++K EE + L E++ + +EE R+ + + L Q
Sbjct: 1967 RRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ 2026
Query: 4338 HALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAH-QSTVEAVNKAGN 4396
A + L +QK E EL + + VL + EA +A
Sbjct: 2027 EAAQKRLQAEEKAHAFAVQQK---------EQELQQTLQQEQSVLDQLRGEAEAARRAAE 2077
Query: 4397 DLIES--SAGEEASNLQNKLEVLNQRWQNVLEKTEQ-----------RKQQLDGALRQAK 4443
+ E+ A EA+ + ++E + Q+ E+ + RK+ A R+A+
Sbjct: 2078 EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQ 2137
Query: 4444 GFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEET--YKSLM 4501
+ Q + E+H ++ +T +++ V E+ EET K+L+
Sbjct: 2138 AEQAALRQKQAADAEMEKHKKFAE------QTLRQKAQVEQELTTLRLQLEETDHQKNLL 2191
Query: 4502 QKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNE---RKTKLE-EALNLAMEFHNS 4557
+ Q L K+ T + + ++E+ SV ++ E K ++E E L + ++
Sbjct: 2192 DEELQRL----KAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDN 2247
Query: 4558 LQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLK 4617
Q F+ +AE+ VA + L + + A E + + + E K
Sbjct: 2248 TQRFLQ--EEAEKMKQVAEEAAR-LSVAAQEAARLRQLAEEDLAQQRALAE--------K 2296
Query: 4618 YFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSL-DDARKRAKQFHEAWSKLMEWLEE 4676
+K V L + ++ + E+ R L +D + A+Q E LE
Sbjct: 2297 MLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA 2356
Query: 4677 SEKSLDSELEIANDPDKIKTQLAQ--------HKEFQKSLGAKHSVYDTTNRTGRSLKEK 4728
+ +LE++ + +++K ++A+ ++ Q+ + + +RT + +EK
Sbjct: 2357 ERQ---RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEK 2413
Query: 4729 TSLAD-----------DNLKLDDMLSELRDKWDTICG-------KSVERQNKLEEALLFS 4770
+L D +L + ++EL + + + KS E Q +E LL
Sbjct: 2414 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLL-- 2471
Query: 4771 GQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKR 4830
Q T ALQ +L + L ++ + + + L + A ++L + Q
Sbjct: 2472 -QETQALQQ--SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2528
Query: 4831 SARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLE 4890
R+ + S +++ + + +E R + + +LE RQ EE
Sbjct: 2529 QERQRLVASMEEARRRQHEAEEGVRRKQ-------EELQQLEQQRRQQEEL--------- 2572
Query: 4891 WLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKAT 4937
LAE Q LR + L+ L +QH+ + EE A AT
Sbjct: 2573 -LAEENQRLR---------EQLQLLEEQHRAALAHSEEVTASQVAAT 2609
Score = 85.1 bits (209), Expect = 2e-15
Identities = 295/1541 (19%), Positives = 608/1541 (39%), Gaps = 226/1541 (14%)
Query: 3708 EASQAQMRPKELKKEAKNNKALLDSLN-------EVSSAL--------LELVPWRAREGL 3752
EA++A + K+L+ +A+ + D+L EV L +E+ WR R
Sbjct: 1112 EATKASL--KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRER--- 1166
Query: 3753 EKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIR 3812
VA+ ER++ V + E++ + + + ++AD +W+ + ++ + +
Sbjct: 1167 ---VAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1223
Query: 3813 LEQDQT-SAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQ--SMKKKLDKVL 3869
L Q QL+ ++ EI RH + +++ + + + A + E Q + K +L+ V
Sbjct: 1224 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA 1283
Query: 3870 KNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQ 3929
+ + QS + Y +L +E ++ SQ ETLR+
Sbjct: 1284 SP------------AKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIK--FISETLRR 1329
Query: 3930 QQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKK 3989
+EE R + AE + + ++ + +L+ + + A L +++E+V +
Sbjct: 1330 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1389
Query: 3990 RAVALDEAISQSTQFHDKIDQILESLERIVE-RLRQPPSISAEVEKIKEQISENKNVSVD 4048
R A +A Q +++ Q+ +S E ++ + RQ + +I+E+I
Sbjct: 1390 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR-------- 1441
Query: 4049 MEKLQPLYETLKQRG----EEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEERE 4104
+ +LQ L T +QRG E R+ + + + Q++ +++ + +E +
Sbjct: 1442 VVRLQ-LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLR------RQVQDESQ 1494
Query: 4105 AKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIRE-EID 4163
K +ELA + + + ++ Q ++ LE+ + Q +EA +R+ E++
Sbjct: 1495 RKRQAEVELASRVKAEAEAA----REKQRALQALEELRL------QAEEAERRLRQAEVE 1544
Query: 4164 GLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWD-SLNKAWKDRIDKLEEAMQA 4222
++ + + E E + + S E + + SL + EEA +
Sbjct: 1545 RARQ-----VQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERR 1599
Query: 4223 AVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLN 4282
A Q + +A + A +L + ++ Q EE+ Q KS A Q E E+
Sbjct: 1600 AQQQAEAERAREE----AERELERWQLKANEALRLRLQAEEVAQQKSLA---QAEAEKQK 1652
Query: 4283 HQAELLLKKVTEESDKHTVQDPLMELKLIWD-SLEERIINRQHKLEGALLALG------- 4334
+AE ++ + ++ Q L E +L L E ++ E L+ L
Sbjct: 1653 EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1712
Query: 4335 QFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKA 4394
Q + L+E LA L ++++ + +E ELAK +LA ++ E +++
Sbjct: 1713 QQRQLLEEELARLQREAAAATQKR------QELEAELAKVRAEMEVLLASKARAEEESRS 1766
Query: 4395 GNDL----IESSAG------EEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKG 4444
++ +E+ AG EEA+ L+ E ++ Q E +++ + + L +
Sbjct: 1767 TSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLA 1826
Query: 4445 FHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKG 4504
GE L+ TE + + E E+L + AF+ + ++ K
Sbjct: 1827 AIGEATRLK-----TEAEIALKEK-----EAENERLR-RLAEDEAFQRRRLEEQAAQHKA 1875
Query: 4505 --QQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFI 4562
++ LA+ K++++ +++ VE L +R+ EE L L F +
Sbjct: 1876 DIEERLAQLRKASDSELERQKG-------LVEDTLRQRRQVEEEILALKASFEKAAAG-- 1926
Query: 4563 NWLTQAEQTLNVASRPSLILDTV-------LFQIDEHKVFANEVNSHREQIIELDKTGTH 4615
+AE L + S DT+ L + ++ A E RE + K+
Sbjct: 1927 ----KAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAA 1982
Query: 4616 LKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLE 4675
+ ++++ L + V+RL + R+RA+Q E+ +L E
Sbjct: 1983 EEEAARQRKAAL-------------EEVERLKAKVEEARRLRERAEQ--ESARQLQLAQE 2027
Query: 4676 ESEKSLDSELEIANDPDKIKTQLAQHKE--FQKSLGAKHSVYDTTNRTGRSLKEKTSLAD 4733
++K L +E +K Q KE Q++L + SV D + + A+
Sbjct: 2028 AAQKRLQAE-------EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE 2080
Query: 4734 D-NLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLA 4792
+ ++ + ++ R + VE +L+++ Q QA + L + Q A
Sbjct: 2081 EARVQAEREAAQSR--------RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2132
Query: 4793 E-----DQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVK 4847
+Q ++ HK F ++ ++ + V+ + R +E + + +
Sbjct: 2133 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2192
Query: 4848 VQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPD 4907
++Q L + L + Q EE L+ EAE ++
Sbjct: 2193 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSK-----LKARIEAEN----RALILR 2243
Query: 4908 DEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFE 4967
D+D + + + E MK++ E+ A L+ A + + D + RA E
Sbjct: 2244 DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED--------LAQQRALAE 2295
Query: 4968 EVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALI 5027
++L K+ Q + A L A+ ELL+ Q L + +++ Q EE +
Sbjct: 2296 KML---KEKMQAVQEA-TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGF- 2350
Query: 5028 AEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSG 5087
Q +E ++Q ++ + K R A+ S Q+ + A R R A +
Sbjct: 2351 ---QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA----EEDAQRFRKQAEEIGEKL 2403
Query: 5088 SQTQIETKNPRVNLLVSKWQQVWLLALERRR------KLNDALDRLEELREFANFDFDIW 5141
+T++ T+ K V L ++R++ +L +A+ LE +E + +
Sbjct: 2404 HRTELATQ--------EKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL 2455
Query: 5142 RKKYMRWMNHKKSRVMDFFRRIDK----DQDGKITRQEFID 5178
+ K ++ +++ + + + ++D + R+ FI+
Sbjct: 2456 QLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE 2496
Score = 78.6 bits (192), Expect = 2e-13
Identities = 352/1885 (18%), Positives = 731/1885 (38%), Gaps = 251/1885 (13%)
Query: 3336 QRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRL 3395
QR +L+++ L L+ LL+W+ + + V + + V+AQ+ + L +
Sbjct: 498 QRRPELEDSTLRY------LQDLLAWVEENQHRVDGAEW-GVDLPSVEAQLGSHRGLHQS 550
Query: 3396 LDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGI-S 3454
+++ ++ +E + + +++ PA + L LD ++ LLN ++ R R LE + S
Sbjct: 551 IEEFRAKIERARSDEGQLS----PATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHS 606
Query: 3455 VVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQ 3514
VA E + WL E+ V + + + + + + AL ++ K + +
Sbjct: 607 FVAAATKELM-----WLNEKEEEEVGFD-WSDRNTNMTAKKESYSALMRELELKEKKIKE 660
Query: 3515 AVSIGQSL--KVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGED 3572
+ G L + +R + Q+ L W +LQ C
Sbjct: 661 LQNAGDRLLREDHPARPTVESFQAALQTQWSW-------------MLQLCCC-------- 699
Query: 3573 EVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQ-ALLNGLEL 3631
E H K + Q +S + + + +L+ LQE L RK + D+ A + LE
Sbjct: 700 --------IEAHLKENAAYFQFFS--DVREAEGQLQKLQE-ALRRKYSCDRSATVTRLED 748
Query: 3632 LKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDK 3691
L Q DE +++L K + +AK + +QL R H H
Sbjct: 749 LLQDAQDE----KEQLNEYKGHL-------SGLAKRAKAVVQLKPR-HPAHPMRGRLPLL 796
Query: 3692 VEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVS-SALLELVPWRARE 3750
+ E V KG+E + + K L S +E + ++ LVP +E
Sbjct: 797 AVCDYKQVEVTVHKGDECQLVG------PAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQE 850
Query: 3751 GLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGD 3810
E + + + LV T+ ++ ++L Q + SW T + L
Sbjct: 851 AQEAVTRLEAQHQALV--TLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKP--- 905
Query: 3811 IRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLK 3870
EQ Q L+ L ++ + D +G E++ +++
Sbjct: 906 --EEQRQALHSLE---------LHYQAFLRDSQDAG-----GFGPEDRLMAEREYGSCSH 949
Query: 3871 NYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQ 3930
+Y + Q + + R Q +++ + +L T T + +L P
Sbjct: 950 HYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRT---VHRLRLPL--------D 998
Query: 3931 QEEHRQLRELIAEHKPHIDKMNKTGPQLLELS--PGEGFSIQEKYVAADTLYSQIKEDVK 3988
+E R+ + IAE + ++ G + LS + ++ E AA TL S+++ +
Sbjct: 999 KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLG 1058
Query: 3989 KRAVALDEAISQSTQFHDKIDQIL----------ESLERIVERLRQPPSISAEVEKIKEQ 4038
K L++ S S + +K+ I E L E+L++ ++ A + +++
Sbjct: 1059 K----LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEAT 1114
Query: 4039 ISENKNVSVDMEKLQPLYETLKQR-------GEEMIARSGGTDKDISAKAVQDKLDQMVF 4091
+ K + E QP ++ L+ GE + R G ++D+ + ++++ Q++
Sbjct: 1115 KASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHG--ERDVEVERWRERVAQLLE 1172
Query: 4092 IWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLED-PGIDPSVVKQ 4150
W+ + + R+ +L + + L ++D + ++ P D V++
Sbjct: 1173 RWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVRE 1232
Query: 4151 QQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIV--KKSID---------ELN 4199
Q + + EEI+ E+++ + I A + + +V K ++ ++
Sbjct: 1233 QLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQ 1292
Query: 4200 SAWDSLNKAWKDRIDKLEEAMQAAVQY----QDGLQAVFDWVDIAGGKLAS----MSPIG 4251
S +S+ + + D E QY + L+ + + +A + A ++ +
Sbjct: 1293 SGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVE 1352
Query: 4252 TDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKK---VTEESDKHTVQDPLMEL 4308
LE +Q E Q K++A ++ E+++ Q E++ ++ V + K ++Q+ L +L
Sbjct: 1353 AALEKQRQLAEAHAQAKAQAEREAKELQQ-RMQEEVVRREEAAVDAQQQKRSIQEELQQL 1411
Query: 4309 KLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIE 4368
+ S E I + + E A + + + + + L TE + GG ++
Sbjct: 1412 R---QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATE------RQRGGAEGELQ 1462
Query: 4369 IELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEE---ASNLQNKLEVLNQRWQNVL 4425
A+ + Q E + + D + E AS ++ + E ++ Q L
Sbjct: 1463 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREK-QRAL 1521
Query: 4426 EKTEQRKQQLDGALRQAKGFHGEIE---DLQQWLTDTERHL---LASKPLGGLPETAKEQ 4479
+ E+ + Q + A R+ + E+E +Q L +R L SK +TA+ +
Sbjct: 1522 QALEELRLQAEEAERRLR--QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE 1579
Query: 4480 LNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNE 4539
++ E A + +EE + Q+ + AR E E +L
Sbjct: 1580 RSLQEEHVAVAQLREEAERRAQQQAEAERAR--------------------EEAERELER 1619
Query: 4540 RKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEV 4599
+ K EAL L ++ Q +AE+ A R + Q + A +
Sbjct: 1620 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1679
Query: 4600 NSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKR 4659
+ Q+ E GT + + +Q+++ ++ + + + + + L R A ++
Sbjct: 1680 LEKQRQLAE----GTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK 1735
Query: 4660 AKQFHEAWSKL---MEWLEESEKSLDSELEIANDPDK--IKTQLAQHKEFQKSLGAKHSV 4714
++ +K+ ME L S+ + E ++ K ++ + + +E + ++
Sbjct: 1736 RQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRAL 1795
Query: 4715 YDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFT 4774
+ R R L E+ + A + + +L+E G++ + + E AL
Sbjct: 1796 AEEAKRQ-RQLAEEDA-ARQRAEAERVLAEKL----AAIGEATRLKTEAEIALKEKEAEN 1849
Query: 4775 DALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARE 4834
+ L+ L + + + E+Q D+ L KA EL ++ V+ R R+
Sbjct: 1850 ERLRRLAE-DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQ 1908
Query: 4835 L------IEGSRDDSSWVKVQMQ-ELS-TRWETVCALSISKQTRLEAALRQ---AEE--- 4880
+ ++ S + ++ K +++ EL R L +Q LEAA ++ AEE
Sbjct: 1909 VEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERR 1968
Query: 4881 FHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRA-ELNKATTM 4939
+ + LA E+ R ++ + L+ +++ + ++ E++ A +L A
Sbjct: 1969 RREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA 2028
Query: 4940 GDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQ----QRLASALAGLIAKQELLE 4995
L K ++ + +E+ +Q Q Q A A A +E E
Sbjct: 2029 AQKRLQ-------AEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2081
Query: 4996 A-LLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRR 5054
A + A + A++ ++ E + Q EE A+ Q E++ RK+ + + +R
Sbjct: 2082 ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL-RKEAEQEAA----RRA 2136
Query: 5055 AADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGS--------QTQIETKNPRVNLLVSKW 5106
A+ ++L+ D K+F +L + Q+E + + NLL +
Sbjct: 2137 QAEQAALRQK-QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEEL 2195
Query: 5107 QQVWLLALERRRKLNDALDRLEELR 5131
Q++ A E R+ + + L +R
Sbjct: 2196 QRLKAEATEAARQRSQVEEELFSVR 2220
Score = 69.3 bits (168), Expect = 1e-10
Identities = 208/1057 (19%), Positives = 422/1057 (39%), Gaps = 142/1057 (13%)
Query: 4258 KQQIEELKQFKSEAYQQQIEME-------RLNHQAELLLKKVTEESDKHTVQDPLMELKL 4310
K+ E Q +E + Q E+E RL+ +AE +L T++ EL+L
Sbjct: 999 KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRS---ELEL 1055
Query: 4311 IWDSLEE-RIINRQH--KLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAI 4367
LE+ R ++ + KL+ L + Q A + L A E L E + V +
Sbjct: 1056 TLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAH----EEQLKEAQAVPATLPEL 1111
Query: 4368 EIELAKHHVLQNDVLAHQSTVEAVN------KAGNDLIESSAGE---EASNLQNKLEVLN 4418
E A L+ A Q T +A+ + + ++ GE E + ++ L
Sbjct: 1112 EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLL 1171
Query: 4419 QRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTER--HLLASKPLGGLPETA 4476
+RWQ VL +T+ R+++L+ RQ + + + L WL D R + + PL +
Sbjct: 1172 ERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLAD-SQAV 1230
Query: 4477 KEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETK 4536
+EQL +E+ +++ + + C + A+ Q IN +K+ E +
Sbjct: 1231 REQLR-----------QEQALLEEIERHGEKVEECQRFAK----QYINAIKD----YELQ 1271
Query: 4537 LNERKTKLEEALNLAME------FHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQID 4590
L K +LE + A + + +Q++++ T + + S+ + L +++
Sbjct: 1272 LVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRME 1331
Query: 4591 EHKVFAN-----------EVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRW 4639
E + A EV + E+ +L + K ++++ L + + V R
Sbjct: 1332 EEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRRE 1391
Query: 4640 EKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLA 4699
E V ++ RS+ + ++ +Q EA ++ ++E + S L I + ++ QL
Sbjct: 1392 EAAVDAQQQK-RSIQEELQQLRQSSEA--EIQAKARQAEAAERSRLRIEEEIRVVRLQL- 1447
Query: 4700 QHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVER 4759
+ E Q+ GA+ + R + +K ++ + + +++D+ VE
Sbjct: 1448 EATERQRG-GAEGELQALRARAEEAEAQKRQAQEE---AERLRRQVQDESQRKRQAEVEL 1503
Query: 4760 QNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDID----LVMNLIDNHKAFQ 4815
++++ + + ALQAL + R++ + AE + +++ + + L ++ +
Sbjct: 1504 ASRVKAEAEAAREKQRALQALEE--LRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1561
Query: 4816 KELGKRTSS----VQALKRSARE---LIEGSRDDSSWVKVQMQELS----------TRWE 4858
EL + +S L+RS +E + R+++ Q E RW+
Sbjct: 1562 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ 1621
Query: 4859 TVCALSISKQTRLEAALRQAEEFHSVVHALLE-WLAEAEQTLRFHGVLPDDEDALRTLID 4917
L ++ RL + + S+ A E EAE+ R G + R L +
Sbjct: 1622 ----LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAE 1677
Query: 4918 QHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQ 4977
Q E ++L E A+ A + + + + + AR + A A Q +
Sbjct: 1678 QELEKQRQLAEGTAQQRLAAEQ-ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKR 1736
Query: 4978 QRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEM 5037
Q L + LA + A+ E+L A A + + ++K K+ + E + L EE
Sbjct: 1737 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL-------AEEA 1789
Query: 5038 TRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETKNP 5097
R + ++ K ++ A + ++ Q RA +R A L G T+++T+
Sbjct: 1790 ARLRALAEE-AKRQRQLAEEDAARQ---------RAEAERVLAEKLAAIGEATRLKTEAE 1839
Query: 5098 RVNLLVSKWQQVWLLALERRRKLNDALDRLEELREFANFDFDIWRKKYMRWMNHKKSRVM 5157
+AL+ + N+ L RL E F R++ K+ +
Sbjct: 1840 --------------IALKEKEAENERLRRLAEDEAFQ-------RRRLEEQAAQHKADIE 1878
Query: 5158 DFFRRIDKDQDGKITRQE-FIDGILSSKFPTSRLEMSAVADIFDRDGDGYIDYYEFVAAL 5216
+ ++ K D ++ RQ+ ++ L + E+ A+ F++ G + + +
Sbjct: 1879 ERLAQLRKASDSELERQKGLVEDTLRQRRQVEE-EILALKASFEKAAAGKAELELELGRI 1937
Query: 5217 HPNKDAYKPITDADKIEDEVTRQVAKCKCAKRFQVEQ 5253
N + + ++E RQ+A + +R + E+
Sbjct: 1938 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEE 1974
Score = 40.0 bits (92), Expect = 0.064
Identities = 84/510 (16%), Positives = 207/510 (40%), Gaps = 52/510 (10%)
Query: 1078 EKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQI-RTPLER 1136
+ E+ K++ ++ L+ + EQE + L + E + + L+ RL + +R
Sbjct: 2150 DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR 2209
Query: 1137 DDLHESVFRITEQ----EKLKKELER----------------LKDDLGTITNKCEEFFSQ 1176
+ E +F + Q KLK +E L+++ + EE
Sbjct: 2210 SQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARL 2269
Query: 1177 AAASSSVPTLRSELNVVLQNMNQVYSMSSTYI-DKLKTVNLVLKNTQAAEALVKLYETKL 1235
+ A+ LR + +++ Q +++ + +K++ V + AE L + E
Sbjct: 2270 SVAAQEAARLRQ---LAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ 2326
Query: 1236 CEEEAVIADKNNI-ENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERD 1294
+ + DK + + L + ++ ++ +RQ + E ++ K EM + +
Sbjct: 2327 EQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAE 2386
Query: 1295 LDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQR 1354
D +++A+++ E+ + ++ ++ + + L + I ++E +
Sbjct: 2387 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKE 2446
Query: 1355 KIQ-ENQPENSKTLATQLNQQKMLVSEIE-MKQSKMDEC------QKYAEQYSATVKD-Y 1405
K+Q E + K+ Q QQ+ L+ E + ++QS + E +++ EQ A ++ +
Sbjct: 2447 KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLF 2506
Query: 1406 ELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRY--------------TALV 1451
+ + + + + QQ+ ++++M+ ++ + R R L
Sbjct: 2507 QDEVAKAQQLREEQQR---QQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE 2563
Query: 1452 TLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPF 1511
Q + + +RL E+ + LEE+ + + ++E+ +KTL + A P
Sbjct: 2564 QQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPA 2623
Query: 1512 SKQKISSEEISTKKEQLSEALQTIQLFLAK 1541
++ + +++ ++ LQ + A+
Sbjct: 2624 AEAEPEHSFDGLRRKVSAQRLQEAGILSAE 2653
Score = 35.0 bits (79), Expect = 2.1
Identities = 73/348 (20%), Positives = 135/348 (38%), Gaps = 54/348 (15%)
Query: 4633 ISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLM-------EWLEESEKSLDSEL 4685
+ V+ W K+ ++ER + L +R + +KL E L +++ L S++
Sbjct: 350 LDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDV 409
Query: 4686 -------------EIANDPDKIKTQLAQ-HKEFQKSLGAKHSVYDTTNRTGRSLKEKTSL 4731
E+ D DK + + + Q +H + R L E+
Sbjct: 410 RLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVA 469
Query: 4732 --ADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEP 4789
+ NL+L ++ + + +SV+R+ +LE++ L LQ L+ W+ E
Sbjct: 470 IRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTL------RYLQDLLAWVE--EN 521
Query: 4790 QLAEDQPVHG-DIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSR----DDSS 4844
Q D G D+ V + +H+ + + + + ++ + +L +R D
Sbjct: 522 QHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLG 581
Query: 4845 WVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHAL---LEWLAEAEQTLRF 4901
+ +Q +L L+ SK A LR E HS V A L WL E E+
Sbjct: 582 RLDLQYAKL---------LNSSK-----ARLRSLESLHSFVAAATKELMWLNEKEEE-EV 626
Query: 4902 HGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHP 4949
D + + + M++LE K ++ + GD +L HP
Sbjct: 627 GFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHP 674
Score = 35.0 bits (79), Expect = 2.1
Identities = 22/51 (43%), Positives = 26/51 (50%)
Query: 5433 EDSGLITTAAARVRTQFADSKKTPSRPGSRAGSKAGSRASSRRGSDASDFD 5483
E +GL AA T+ S + S GS AGS+ GSR SR GS FD
Sbjct: 4443 EGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTGSRTGSRAGSRRGSFD 4493
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 861 bits (2224), Expect = 0.0
Identities = 637/2272 (28%), Positives = 1151/2272 (50%), Gaps = 200/2272 (8%)
Query: 641 EEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKI 700
E+ ++++QDLL WV+E Q ++D EWG DLPSVE+ L +H+ +H++IEEF + ++ A+
Sbjct: 545 EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS 604
Query: 701 SEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE 760
E Q++ + Y + L RL+ QYAKLLN+S+ + R L++LH+FV+ AT EL+WLNEKEE
Sbjct: 605 DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE 664
Query: 761 EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR 820
EEV +DWS+RNTN+ KK+ ++ LMREL+ KE+ IK +Q ++LL E+HPAR T+E+++
Sbjct: 665 EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 724
Query: 821 AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSI 880
AA+QTQWSW+LQLC C+E H+KEN AYF+FF+D +EA L+ L++A++RKYSCDRS+++
Sbjct: 725 AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATV 784
Query: 881 HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ 940
+LEDL+Q++ +EKE+L +YK ++ L +AK ++QLKPR+ P++ +P+ A+CDY+Q
Sbjct: 785 TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 844
Query: 941 IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ 1000
+E+T++K DEC L + + WKV+S +G+EA VPSVCF VPPPN+EA + R+E Q+Q
Sbjct: 845 VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ 904
Query: 1001 NVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFL 1060
++TLWH+ H++MKS+++W L ++ IR+ ++A+ +T+ P E +Q L +L+ ++ FL
Sbjct: 905 ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 964
Query: 1061 EDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLE 1120
DSQ++ F D E+E C +YQ+LL+S E+ QEES ISE+++IRL+LE
Sbjct: 965 RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE 1024
Query: 1121 NCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAAS 1180
CE R + ++R PL+++ E RI EQ+K + E+E L + ++ + E+ + S
Sbjct: 1025 ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1084
Query: 1181 SSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEA 1240
+ PTLRSEL + L + QV S+S+ Y++KLKT++LV++ TQ AE +++ +E +L E +A
Sbjct: 1085 PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1144
Query: 1241 VIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWH 1300
V A +E ++LK+ R++ + ++ F AL DEL+ A+ + + + + + ERD++ +
Sbjct: 1145 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1204
Query: 1301 KEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQ 1360
+E+ QL+ERWQ V Q D R R+LE +G+ L+YYR++ PL W+Q Q +IQ
Sbjct: 1205 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1264
Query: 1361 PENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQ 1420
+S+ + QL Q++ L+ EIE K++ECQ++A+QY +KDYELQ +TY+A ++
Sbjct: 1265 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLE-PV 1323
Query: 1421 KSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKK 1480
SP K+ ++QS ++ +IQE++DLRT Y+ L TL +QYIKF ++L+R+EEEE+ E+++
Sbjct: 1324 ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRA 1383
Query: 1481 E------HVEKAKELQKWVSNISKTLK-DAEKAGKPPFSKQKISSEEISTKKEQLSEALQ 1533
E VE A E Q+ ++ K AE+ K Q+ EE+ ++E +A Q
Sbjct: 1384 EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAK---ELQQRMQEEVVRREEAAVDAQQ 1440
Query: 1534 TIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKI-V 1592
++ ++++++ L++S +Q + ++ S +++EE+I V
Sbjct: 1441 ----------------QKRSIQEELQQLRQSSEAEIQAKARQAEAAERS-RLRIEEEIRV 1483
Query: 1593 AERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQ--EELQKDMQGS 1650
Q E E+ +G + G +A E +K Q+++ E L++ +Q
Sbjct: 1484 VRLQLEATERQRGGAE----------GELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1533
Query: 1651 AQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVT 1710
+Q + + +K E ++ +AL Q L E +++ E+ + Q++ E + V
Sbjct: 1534 SQRKRQAEVELASRVKAEAEAAREKQRAL--QALEELRLQAEEAERRLRQAEVERARQVQ 1591
Query: 1711 TAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDG 1770
A+ ET + +A +L+ + L ++ A + ++ E+ Q+ +
Sbjct: 1592 VAL--ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ--QQAEA 1647
Query: 1771 KSAIGE-EDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQ 1829
+ A E E E+ L+ + ++ E + QQ +A+ EK + A+
Sbjct: 1648 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK----------QKEEAE 1697
Query: 1830 VLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEF 1889
++G+ EE+ Q+ + E ++ + LAE + +L + ++EL + A+ +
Sbjct: 1698 REARRRGK---AEEQAVRQRELAEQELEKQRQLAEGTAQQRL--AAEQELIRLRAETEQG 1752
Query: 1890 EHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAK 1949
E Q E+EL L+ A ++++ ++ + ++ + S R E ++
Sbjct: 1753 EQQRQLLEEELARLQREA------AAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1806
Query: 1950 SCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCG 2009
S S++ +++ A R+L R R+L + ++ D + +A
Sbjct: 1807 STSEKSKQRLEAEAGR---FRELAEEAARLRALAEEAKRQRQLAEE--DAARQRAEAERV 1861
Query: 2010 LLAGLQAC-EATASKHLSEPIAVDPKNLQ----RQLEETKALQGQISSQQVAVEKLKKTA 2064
L L A EAT K +E IA+ K + R+L E +A Q + +Q A K
Sbjct: 1862 LAEKLAAIGEATRLKTEAE-IALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHK----- 1915
Query: 2065 EVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEML 2124
D L + L+ G ED + + E++ L+++ ++
Sbjct: 1916 ---ADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEI-------LALKASFEKAA 1965
Query: 2125 DWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDP 2184
G E L E G++ N+ +D + E + A RQ + A E+ ++ E
Sbjct: 1966 --AGKAELEL-ELGRIRSNA---EDTLRSKEQAELE-AARQRQLAAEEERRRREAE---- 2014
Query: 2185 STASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALT 2244
+ K L+A EA+ + K L ++E LK KVE L E+ + + Q
Sbjct: 2015 ------ERVQKSLAAE-EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ 2067
Query: 2245 EVDVPGKDVTE------LSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLE 2298
E E + Q QE + + L+ L + +++A V +
Sbjct: 2068 EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARV-Q 2126
Query: 2299 KTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGA 2358
++ +++E+ + K+ A Q + A K K +E ++ Q +
Sbjct: 2127 AEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQ 2186
Query: 2359 EDLGKS-LEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLN 2417
+ + +E KK E+ + ++++ ++ L T K + + L
Sbjct: 2187 KQAADAEMEKHKKFAEQTLRQKAQVEQ----ELTTLRLQLEETDHQKNL--LDEELQRLK 2240
Query: 2418 GEGTATNTEEFWANKGLTSIKKDMTDISH-----GYEDLGLLLKDKIAELNTKLSKLQKA 2472
E T + + L S++ M ++S E+ L+L+DK NT+ +
Sbjct: 2241 AEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKD---NTQ----RFL 2293
Query: 2473 QEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQE---L 2529
QEE+ M Q ++ + + Q+ A A + +Q E LK+ + VQE L
Sbjct: 2294 QEEAEKMKQVAEEAARLSVAAQEA-ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2352
Query: 2530 KDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQ-TVE 2588
K + ELL++ + + ++ +L D++Q ++ + FQ T+E
Sbjct: 2353 KAE-AELLQQQKELAQ---------------EQARRLQEDKEQMAQQLAEETQGFQRTLE 2396
Query: 2589 AQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILS 2648
A+ ++ L ++ + +++++ + E + + + E+ +
Sbjct: 2397 AERQRQL------------------EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE 2438
Query: 2649 RPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSD 2708
GE + ++ + Q + Q + + +AI + + + L+
Sbjct: 2439 EIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ------- 2491
Query: 2709 LDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCED----LSALVKEE 2764
+ KL + Q L+ Q ++Q EK + + E L L ++E
Sbjct: 2492 -EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDE 2550
Query: 2765 YLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQN 2824
KA+ R+ + + + +EQ+ + V ++ A H+ ++ R Q L ++++
Sbjct: 2551 VAKAQQLREEQ--QRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRR 2608
Query: 2825 KSHPISA--------KLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLL 2868
+ + A +L +LE + S+ +TA KT+ G + L
Sbjct: 2609 QQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDAL 2660
Score = 619 bits (1597), Expect = e-176
Identities = 304/503 (60%), Positives = 400/503 (79%), Gaps = 6/503 (1%)
Query: 22 DDFSQKSGSASPAPGDTLPWNLPKHERSKRKIQG----GSVLDPAERAVLRIADERDKVQ 77
+D S S S SP+PGDTLPWNL K +RS+R G GSVLDPAERAV+RIADERD+VQ
Sbjct: 13 EDVSNGS-SGSPSPGDTLPWNLGKTQRSRRSGGGAGSNGSVLDPAERAVIRIADERDRVQ 71
Query: 78 KKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEVLSGDTLPREKGRMRFHRLQNVQ 137
KKTFTKW+N+HL+K ++H++DLYEDLRDGHNLISLLEVLSGD+LPREKGRMRFH+LQNVQ
Sbjct: 72 KKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRFHKLQNVQ 131
Query: 138 IALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIHVTGESEDMSAKERL 197
IALDYL+ RQVKLVNIRNDDI DGNPKLTLGLIWTIILHFQISDI V+G+SEDM+AKE+L
Sbjct: 132 IALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDMTAKEKL 191
Query: 198 LLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAVQSNLANLEHAFY 257
LLW+Q+ EGY G+RC+NFT+ WRDG+LFNAIIH+++P LIDMN V Q+NL NL+ AF
Sbjct: 192 LLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQAFS 251
Query: 258 VAEK-IGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAFPKVPEGGEGIGANDVEVKWIEY 316
VAE+ +GV RLLDPEDVDV PDEKS+ITYVSSLYDA P+VP+ +G+ AN+++++W EY
Sbjct: 252 VAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANELQLRWQEY 311
Query: 317 QNMVNYLIQWIRHHVTTMSERTFPNNPVELKALYNQYLQFKETEIPPKETEKSKIKRLYK 376
+ +V L+QW+RHH ER FP++ E++ L++Q+L+FKE E+P KE +K++ K +Y+
Sbjct: 312 RELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQ 371
Query: 377 LLEIWIEFGRIKLLQGYHPNDIEKEWGKLIIAMLEREKALRPEVERLEMLQQIANRVQRD 436
LE ++ G++K+ GYHP D+EKEWGKL +A+LEREK LR E ERLE LQ+I ++Q +
Sbjct: 372 SLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQME 431
Query: 437 SVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLLRQHVIDVQILIDGKY 496
+ +CE++L A LQSD + L +G Q E+ + + ++++R DVQ L DG++
Sbjct: 432 AGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRH 491
Query: 497 YQADQLVQRVAKLRDEIMALRNE 519
Q +Q+ +RV +L + ++A+R E
Sbjct: 492 PQGEQMYRRVYRLHERLVAIRTE 514
Score = 111 bits (277), Expect = 2e-23
Identities = 355/1874 (18%), Positives = 725/1874 (38%), Gaps = 306/1874 (16%)
Query: 2676 GQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQK 2735
G S + Q++ + Q +S + +L D+ +L + + H + E A++
Sbjct: 986 GSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARE 1045
Query: 2736 MKQEI-QQEKKQIKVA---------QALCEDLSALVKEEYLKAELSRQLEGILKSFKDVE 2785
Q I +Q+K Q +V A E + AL + L +LE L + V
Sbjct: 1046 CAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVR 1105
Query: 2786 QKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKD 2845
+ +++ L++ Q +A + KE Q + A L LE+ K
Sbjct: 1106 SLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQ----AVPATLPELEAT----KA 1157
Query: 2846 FSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQ----------------LNTIKTN 2889
K L AQ+ + T + L + +G+++ +LQ + +
Sbjct: 1158 SLKKLRAQAEAQQPTF---DALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLER 1214
Query: 2890 WDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFC--LDPAEGENS 2947
W Q R+ +L++ + Y+E + L W+ + E+I+ D
Sbjct: 1215 WQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQ 1274
Query: 2948 IAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSK 3007
+ + ++L +E+++H VE A ++ K
Sbjct: 1275 LRQEQALLEEIERHGEKVEECQRFAKQYINAI---------------------------K 1307
Query: 3008 KFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQA 3067
+ L+ +T K + S K ++Q E + I + + + + ++ T+ K +
Sbjct: 1308 DYELQLVTYKAQLEPVASPAKKPKVQSGSESV-IQEYVDLRTHYSELTTLTSQYIKFISE 1366
Query: 3068 LKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVET-IAQEHSTLSQQVDEKCSFLETKLQG 3126
+++ +RLA+ E + + L+ + +A+ H+ Q + + L+ ++Q
Sbjct: 1367 TLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ- 1425
Query: 3127 IGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKET-IKAFLKKLEALMASNDNA 3185
E+ + D + + + L++ E I+A ++ EA S
Sbjct: 1426 --------EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRI 1477
Query: 3186 NKTCKMM-LATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKL 3244
+ +++ L E T G + +L+AL +AR E+ E ++ +E +L
Sbjct: 1478 EEEIRVVRLQLEATERQRGGAEGELQAL-----------RARAEEAEAQKRQAQEEAERL 1526
Query: 3245 KEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLI 3304
+ + +ESQ E E ++ K E E + KQ+ + L + +
Sbjct: 1527 RR--------QVQDESQRKRQAEVELASRV--------KAEAEAAREKQRALQALEELRL 1570
Query: 3305 QSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVD 3364
Q+ + L + +RA Q+Q AL
Sbjct: 1571 QAEEAE-----------------RRLRQAEVERARQVQVAL------------------- 1594
Query: 3365 TEELVANQKPPSAEFKVVKAQIQEQKL-LQRLLDDRKSTVEVIKREGEKIATTAEPADKV 3423
Q+ AE + +A E+ L+R L + V ++ E E+ A A++
Sbjct: 1595 ----ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERA 1650
Query: 3424 KILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEP 3483
+ + L RW+ N+A Q E VAQQ + L + EK+ E
Sbjct: 1651 REEAEREL--ERWQLKANEALRLRLQAEE---VAQQ-----KSLAQ--AEAEKQKEEAER 1698
Query: 3484 IGTQASKLEEQIAQHKALEDDIINHNKHLHQAVS---IGQSLKVLSSREDKDMVQSKLDF 3540
+ K EEQ + + L + + + L + + + +++ R + + + +
Sbjct: 1699 EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL 1758
Query: 3541 SQVWYIEIQEKSHSRSELLQQALCN-AKIFGEDEVELMNWLN--EVHDKLSKLSVQDYST 3597
+ +Q ++ + ++ Q+ AK+ E EV L + E S+ S Q
Sbjct: 1759 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1818
Query: 3598 EG-----LWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKA 3652
E L ++ + LR L E+ ++Q ++ + +Q E ++ +KL AI
Sbjct: 1819 EAGRFRELAEEAARLRALAEEAKRQRQLAEE------DAARQRAEAE-RVLAEKLAAIG- 1870
Query: 3653 RYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQA 3712
+ T+L T+ L++ RL E+ ++E + ++ + E A
Sbjct: 1871 ---EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI----EERLA 1923
Query: 3713 QMRPKELKKEAKNNKALL-DSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTIT 3771
Q+R K E + K L+ D+L + E++ +A EK A E
Sbjct: 1924 QLR-KASDSELERQKGLVEDTLRQRRQVEEEILALKA--SFEKAAAGKAEL--------- 1971
Query: 3772 QKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTME 3831
E++ +RS D E + + ++ ++ + E+ + A+ +VQK+ E
Sbjct: 1972 ----ELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEE---ERRRREAEERVQKSLAAE 2024
Query: 3832 ---ILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLE- 3887
+ K ++++ + K+ EE + ++++ ++ + Q +++ LQ E
Sbjct: 2025 EEAARQRKAALEEVERLKAKV------EEARRLRERAEQESARQLQLAQEAAQKRLQAEE 2078
Query: 3888 RAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPH 3947
+A + Q E +EL L + QS++ QL A E R+ EE + R
Sbjct: 2079 KAHAFAVQQKE--QELQQTLQQEQSVLDQLRGEA---EAARRAAEEAEEARVQAEREAAQ 2133
Query: 3948 IDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQST----- 4002
+ + +L + + + + + AA+ L + +++ +RA A A+ Q
Sbjct: 2134 SRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAE 2193
Query: 4003 -QFHDK-----------IDQILESLE-RIVERLRQPPSISAEVEKIKEQISENK------ 4043
+ H K ++Q L +L ++ E Q + E++++K + +E
Sbjct: 2194 MEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQV 2253
Query: 4044 -----NVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHT 4098
+V V ME+L L ++ +I R DKD + + +Q++ ++M + E
Sbjct: 2254 EEELFSVRVQMEELSKLKARIEAENRALILR----DKDNTQRFLQEEAEKMKQVAEEAAR 2309
Query: 4099 L-VEEREAKLLDVMELAEKFWCDHMSLIVT-IKDTQDFIRDLEDPGIDPSVVKQQQEAAE 4156
L V +EA L +LAE+ +L +K+ +++ + +++QQ+E A+
Sbjct: 2310 LSVAAQEAARL--RQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ 2367
Query: 4157 TIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKL 4216
E+ LQE+ + ++ E + + E + +A + ++ ++
Sbjct: 2368 ---EQARRLQEDKE-------QMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKL-RV 2416
Query: 4217 EEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQI 4276
E +A + ++ Q + G KL + T+ Q +E I
Sbjct: 2417 AEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE-------------I 2463
Query: 4277 EMERLNHQAELLLKKVTE-ESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQ 4335
+ ++ +H AE L + + E E +K +Q E KL+ EE +Q +L AL Q
Sbjct: 2464 QRQQSDHDAERLREAIAELEREKEKLQQ---EAKLLQLKSEEMQTVQQEQLLQETQALQQ 2520
Query: 4336 FQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEI----ELAKHHVLQNDVLAHQSTVEAV 4391
++L+ + LL ++ + + +E E+AK L+ + Q +E
Sbjct: 2521 ---------SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQE 2571
Query: 4392 NKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIED 4451
+ L+ S EEA Q++ E +R Q L++ EQ+++Q + L + + + +
Sbjct: 2572 RQR---LVASM--EEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEE---NQRLRE 2623
Query: 4452 LQQWLTDTERHLLA 4465
Q L + R LA
Sbjct: 2624 QLQLLEEQHRAALA 2637
Score = 94.0 bits (232), Expect = 4e-18
Identities = 353/1847 (19%), Positives = 705/1847 (38%), Gaps = 283/1847 (15%)
Query: 3201 DLVGIKRDLEALSKQCNKLLDRAQ--AREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHE 3258
D + +R+ + S +LL + A+EE R + S+LK+ + L+ E
Sbjct: 977 DRLMAEREYGSCSHHYQQLLQSLEQGAQEES------RCQRCISELKDIRLQLEACETRT 1030
Query: 3259 ESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAK--------- 3309
+ + ++ E + + I Q Q +V LG+G+ + +A+
Sbjct: 1031 VHRLRLPLDKEPARECA--------QRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPE 1082
Query: 3310 -STSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEEL 3368
S + L +L+ + + + A +L+ L Q A E L + +E
Sbjct: 1083 PSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEA 1142
Query: 3369 VA------NQKPPSAEFKVVKAQIQ-EQKLLQRLLDDRKSTVEVIKREGEKIATTAEPAD 3421
A + A K ++AQ + +Q L D+ + EV +R ++ +
Sbjct: 1143 QAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVE 1202
Query: 3422 KVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNC 3481
+ + ++++ L RW+A+L + + R R+LE + + + E+ +PL WL +R
Sbjct: 1203 RWR--ERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQI 1260
Query: 3482 EPIGTQASK-LEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDF 3540
+ + S+ + EQ+ Q +AL ++I H + + + + + +V K
Sbjct: 1261 QAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQL 1320
Query: 3541 SQVWYIEIQEKSHSRSELLQQALCNAKI-FGEDEVELMNWLNEVHDKLSKLSVQDYSTEG 3599
V + K S SE + Q + + + E ++ + + L ++ ++ E
Sbjct: 1321 EPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE- 1379
Query: 3600 LWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITK 3659
+Q++E R R V+ AL +L + Q K +A + + +
Sbjct: 1380 --QQRAEERE-------RLAEVEAALEKQRQLAEAHA-------QAKAQAEREAKELQQR 1423
Query: 3660 LSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKEL 3719
+ +V + E A+ ++ S EEL E E+ + K +A A+ +
Sbjct: 1424 MQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQA------KARQAEAAERSRLRI 1477
Query: 3720 KKEAKNNKALLDSL-NEVSSALLELVPWRAR----EGLEKMVAEDNERYRLVSDTITQKV 3774
++E + + L++ + A EL RAR E ++ E+ ER R +Q+
Sbjct: 1478 EEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRK 1537
Query: 3775 EEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILR 3834
+ + + AE E ++ L +L ++RL+ ++ +L+ E+ R
Sbjct: 1538 RQAEV------ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR-----QAEVER 1586
Query: 3835 HKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVN 3894
+ V+ + +E E QS + +E+ QLER+
Sbjct: 1587 ARQ-----VQVALETAQRSAEAELQSKRASF--------------AEKTAQLERS----- 1622
Query: 3895 QFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKT 3954
L E ++QL E E QQQ E + RE E + +++
Sbjct: 1623 ------------LQEEHVAVAQLRE---EAERRAQQQAEAERARE---EAERELERWQLK 1664
Query: 3955 GPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILES 4014
+ L L Q+K +A Q KE+ ++ A +A Q+ + + +Q LE
Sbjct: 1665 ANEALRLRLQAEEVAQQKSLAQAEAEKQ-KEEAEREARRRGKAEEQAVRQRELAEQELEK 1723
Query: 4015 LERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTD 4074
++ E Q ++AE E I+ + + E+ + L E R + A +
Sbjct: 1724 QRQLAEGTAQ-QRLAAEQELIRLRAETEQG-----EQQRQLLEEELARLQREAAAATQKR 1777
Query: 4075 KDISAKAVQDKLDQMVFIWENIHTLVEER----------EAKLLDVMELAEKFWCDHMSL 4124
+++ A+ + + + V + E R EA+ ELAE+ +
Sbjct: 1778 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE-----AAR 1832
Query: 4125 IVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQE------ELDIVI---NL 4175
+ + + R L + +Q+ EA + E++ + E E +I +
Sbjct: 1833 LRALAEEAKRQRQL----AEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEA 1888
Query: 4176 GSELIAACGEPDKPIVKKSIDE--------LNSAWDSLNKAWKDRIDK----LEEAMQAA 4223
+E + E D+ ++ ++E + L KA +++ +E+ ++
Sbjct: 1889 ENERLRRLAE-DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQR 1947
Query: 4224 VQYQDGLQAV-FDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQ---IEME 4279
Q ++ + A+ + A GK +G + + +Q + EA +Q+ E E
Sbjct: 1948 RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE 2007
Query: 4280 RLNHQAELLLKK--VTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQ 4337
R +AE ++K EE + L E++ + +EE R+ + + L Q
Sbjct: 2008 RRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ 2067
Query: 4338 HALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAH-QSTVEAVNKAGN 4396
A + L +QK E EL + + VL + EA +A
Sbjct: 2068 EAAQKRLQAEEKAHAFAVQQK---------EQELQQTLQQEQSVLDQLRGEAEAARRAAE 2118
Query: 4397 DLIES--SAGEEASNLQNKLEVLNQRWQNVLEKTEQ-----------RKQQLDGALRQAK 4443
+ E+ A EA+ + ++E + Q+ E+ + RK+ A R+A+
Sbjct: 2119 EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQ 2178
Query: 4444 GFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEET--YKSLM 4501
+ Q + E+H ++ +T +++ V E+ EET K+L+
Sbjct: 2179 AEQAALRQKQAADAEMEKHKKFAE------QTLRQKAQVEQELTTLRLQLEETDHQKNLL 2232
Query: 4502 QKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNE---RKTKLE-EALNLAMEFHNS 4557
+ Q L K+ T + + ++E+ SV ++ E K ++E E L + ++
Sbjct: 2233 DEELQRL----KAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDN 2288
Query: 4558 LQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLK 4617
Q F+ +AE+ VA + L + + A E + + + E K
Sbjct: 2289 TQRFLQ--EEAEKMKQVAEEAAR-LSVAAQEAARLRQLAEEDLAQQRALAE--------K 2337
Query: 4618 YFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSL-DDARKRAKQFHEAWSKLMEWLEE 4676
+K V L + ++ + E+ R L +D + A+Q E LE
Sbjct: 2338 MLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA 2397
Query: 4677 SEKSLDSELEIANDPDKIKTQLAQ--------HKEFQKSLGAKHSVYDTTNRTGRSLKEK 4728
+ +LE++ + +++K ++A+ ++ Q+ + + +RT + +EK
Sbjct: 2398 ERQ---RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEK 2454
Query: 4729 TSLAD-----------DNLKLDDMLSELRDKWDTICG-------KSVERQNKLEEALLFS 4770
+L D +L + ++EL + + + KS E Q +E LL
Sbjct: 2455 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLL-- 2512
Query: 4771 GQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKR 4830
Q T ALQ +L + L ++ + + + L + A ++L + Q
Sbjct: 2513 -QETQALQQ--SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2569
Query: 4831 SARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLE 4890
R+ + S +++ + + +E R + + +LE RQ EE
Sbjct: 2570 QERQRLVASMEEARRRQHEAEEGVRRKQ-------EELQQLEQQRRQQEEL--------- 2613
Query: 4891 WLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKAT 4937
LAE Q LR + L+ L +QH+ + EE A AT
Sbjct: 2614 -LAEENQRLR---------EQLQLLEEQHRAALAHSEEVTASQVAAT 2650
Score = 85.1 bits (209), Expect = 2e-15
Identities = 295/1541 (19%), Positives = 608/1541 (39%), Gaps = 226/1541 (14%)
Query: 3708 EASQAQMRPKELKKEAKNNKALLDSLN-------EVSSAL--------LELVPWRAREGL 3752
EA++A + K+L+ +A+ + D+L EV L +E+ WR R
Sbjct: 1153 EATKASL--KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRER--- 1207
Query: 3753 EKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIR 3812
VA+ ER++ V + E++ + + + ++AD +W+ + ++ + +
Sbjct: 1208 ---VAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1264
Query: 3813 LEQDQT-SAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQ--SMKKKLDKVL 3869
L Q QL+ ++ EI RH + +++ + + + A + E Q + K +L+ V
Sbjct: 1265 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA 1324
Query: 3870 KNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQ 3929
+ + QS + Y +L +E ++ SQ ETLR+
Sbjct: 1325 SP------------AKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIK--FISETLRR 1370
Query: 3930 QQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKK 3989
+EE R + AE + + ++ + +L+ + + A L +++E+V +
Sbjct: 1371 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1430
Query: 3990 RAVALDEAISQSTQFHDKIDQILESLERIVE-RLRQPPSISAEVEKIKEQISENKNVSVD 4048
R A +A Q +++ Q+ +S E ++ + RQ + +I+E+I
Sbjct: 1431 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR-------- 1482
Query: 4049 MEKLQPLYETLKQRG----EEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEERE 4104
+ +LQ L T +QRG E R+ + + + Q++ +++ + +E +
Sbjct: 1483 VVRLQ-LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLR------RQVQDESQ 1535
Query: 4105 AKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIRE-EID 4163
K +ELA + + + ++ Q ++ LE+ + Q +EA +R+ E++
Sbjct: 1536 RKRQAEVELASRVKAEAEAA----REKQRALQALEELRL------QAEEAERRLRQAEVE 1585
Query: 4164 GLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWD-SLNKAWKDRIDKLEEAMQA 4222
++ + + E E + + S E + + SL + EEA +
Sbjct: 1586 RARQ-----VQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERR 1640
Query: 4223 AVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLN 4282
A Q + +A + A +L + ++ Q EE+ Q KS A Q E E+
Sbjct: 1641 AQQQAEAERAREE----AERELERWQLKANEALRLRLQAEEVAQQKSLA---QAEAEKQK 1693
Query: 4283 HQAELLLKKVTEESDKHTVQDPLMELKLIWD-SLEERIINRQHKLEGALLALG------- 4334
+AE ++ + ++ Q L E +L L E ++ E L+ L
Sbjct: 1694 EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1753
Query: 4335 QFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKA 4394
Q + L+E LA L ++++ + +E ELAK +LA ++ E +++
Sbjct: 1754 QQRQLLEEELARLQREAAAATQKR------QELEAELAKVRAEMEVLLASKARAEEESRS 1807
Query: 4395 GNDL----IESSAG------EEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKG 4444
++ +E+ AG EEA+ L+ E ++ Q E +++ + + L +
Sbjct: 1808 TSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLA 1867
Query: 4445 FHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKG 4504
GE L+ TE + + E E+L + AF+ + ++ K
Sbjct: 1868 AIGEATRLK-----TEAEIALKEK-----EAENERLR-RLAEDEAFQRRRLEEQAAQHKA 1916
Query: 4505 --QQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFI 4562
++ LA+ K++++ +++ VE L +R+ EE L L F +
Sbjct: 1917 DIEERLAQLRKASDSELERQKG-------LVEDTLRQRRQVEEEILALKASFEKAAAG-- 1967
Query: 4563 NWLTQAEQTLNVASRPSLILDTV-------LFQIDEHKVFANEVNSHREQIIELDKTGTH 4615
+AE L + S DT+ L + ++ A E RE + K+
Sbjct: 1968 ----KAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAA 2023
Query: 4616 LKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLE 4675
+ ++++ L + V+RL + R+RA+Q E+ +L E
Sbjct: 2024 EEEAARQRKAAL-------------EEVERLKAKVEEARRLRERAEQ--ESARQLQLAQE 2068
Query: 4676 ESEKSLDSELEIANDPDKIKTQLAQHKE--FQKSLGAKHSVYDTTNRTGRSLKEKTSLAD 4733
++K L +E +K Q KE Q++L + SV D + + A+
Sbjct: 2069 AAQKRLQAE-------EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE 2121
Query: 4734 D-NLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLA 4792
+ ++ + ++ R + VE +L+++ Q QA + L + Q A
Sbjct: 2122 EARVQAEREAAQSR--------RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2173
Query: 4793 E-----DQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVK 4847
+Q ++ HK F ++ ++ + V+ + R +E + + +
Sbjct: 2174 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2233
Query: 4848 VQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPD 4907
++Q L + L + Q EE L+ EAE ++
Sbjct: 2234 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSK-----LKARIEAEN----RALILR 2284
Query: 4908 DEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFE 4967
D+D + + + E MK++ E+ A L+ A + + D + RA E
Sbjct: 2285 DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED--------LAQQRALAE 2336
Query: 4968 EVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALI 5027
++L K+ Q + A L A+ ELL+ Q L + +++ Q EE +
Sbjct: 2337 KML---KEKMQAVQEA-TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGF- 2391
Query: 5028 AEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSG 5087
Q +E ++Q ++ + K R A+ S Q+ + A R R A +
Sbjct: 2392 ---QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA----EEDAQRFRKQAEEIGEKL 2444
Query: 5088 SQTQIETKNPRVNLLVSKWQQVWLLALERRR------KLNDALDRLEELREFANFDFDIW 5141
+T++ T+ K V L ++R++ +L +A+ LE +E + +
Sbjct: 2445 HRTELATQ--------EKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL 2496
Query: 5142 RKKYMRWMNHKKSRVMDFFRRIDK----DQDGKITRQEFID 5178
+ K ++ +++ + + + ++D + R+ FI+
Sbjct: 2497 QLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE 2537
Score = 78.6 bits (192), Expect = 2e-13
Identities = 352/1885 (18%), Positives = 731/1885 (38%), Gaps = 251/1885 (13%)
Query: 3336 QRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRL 3395
QR +L+++ L L+ LL+W+ + + V + + V+AQ+ + L +
Sbjct: 539 QRRPELEDSTLRY------LQDLLAWVEENQHRVDGAEW-GVDLPSVEAQLGSHRGLHQS 591
Query: 3396 LDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGI-S 3454
+++ ++ +E + + +++ PA + L LD ++ LLN ++ R R LE + S
Sbjct: 592 IEEFRAKIERARSDEGQLS----PATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHS 647
Query: 3455 VVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQ 3514
VA E + WL E+ V + + + + + + AL ++ K + +
Sbjct: 648 FVAAATKELM-----WLNEKEEEEVGFD-WSDRNTNMTAKKESYSALMRELELKEKKIKE 701
Query: 3515 AVSIGQSL--KVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGED 3572
+ G L + +R + Q+ L W +LQ C
Sbjct: 702 LQNAGDRLLREDHPARPTVESFQAALQTQWSW-------------MLQLCCC-------- 740
Query: 3573 EVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQ-ALLNGLEL 3631
E H K + Q +S + + + +L+ LQE L RK + D+ A + LE
Sbjct: 741 --------IEAHLKENAAYFQFFS--DVREAEGQLQKLQE-ALRRKYSCDRSATVTRLED 789
Query: 3632 LKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDK 3691
L Q DE +++L K + +AK + +QL R H H
Sbjct: 790 LLQDAQDE----KEQLNEYKGHL-------SGLAKRAKAVVQLKPR-HPAHPMRGRLPLL 837
Query: 3692 VEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVS-SALLELVPWRARE 3750
+ E V KG+E + + K L S +E + ++ LVP +E
Sbjct: 838 AVCDYKQVEVTVHKGDECQLVG------PAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQE 891
Query: 3751 GLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGD 3810
E + + + LV T+ ++ ++L Q + SW T + L
Sbjct: 892 AQEAVTRLEAQHQALV--TLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKP--- 946
Query: 3811 IRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLK 3870
EQ Q L+ L ++ + D +G E++ +++
Sbjct: 947 --EEQRQALHSLE---------LHYQAFLRDSQDAG-----GFGPEDRLMAEREYGSCSH 990
Query: 3871 NYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQ 3930
+Y + Q + + R Q +++ + +L T T + +L P
Sbjct: 991 HYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRT---VHRLRLPL--------D 1039
Query: 3931 QEEHRQLRELIAEHKPHIDKMNKTGPQLLELS--PGEGFSIQEKYVAADTLYSQIKEDVK 3988
+E R+ + IAE + ++ G + LS + ++ E AA TL S+++ +
Sbjct: 1040 KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLG 1099
Query: 3989 KRAVALDEAISQSTQFHDKIDQIL----------ESLERIVERLRQPPSISAEVEKIKEQ 4038
K L++ S S + +K+ I E L E+L++ ++ A + +++
Sbjct: 1100 K----LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEAT 1155
Query: 4039 ISENKNVSVDMEKLQPLYETLKQR-------GEEMIARSGGTDKDISAKAVQDKLDQMVF 4091
+ K + E QP ++ L+ GE + R G ++D+ + ++++ Q++
Sbjct: 1156 KASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHG--ERDVEVERWRERVAQLLE 1213
Query: 4092 IWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLED-PGIDPSVVKQ 4150
W+ + + R+ +L + + L ++D + ++ P D V++
Sbjct: 1214 RWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVRE 1273
Query: 4151 QQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIV--KKSID---------ELN 4199
Q + + EEI+ E+++ + I A + + +V K ++ ++
Sbjct: 1274 QLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQ 1333
Query: 4200 SAWDSLNKAWKDRIDKLEEAMQAAVQY----QDGLQAVFDWVDIAGGKLAS----MSPIG 4251
S +S+ + + D E QY + L+ + + +A + A ++ +
Sbjct: 1334 SGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVE 1393
Query: 4252 TDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKK---VTEESDKHTVQDPLMEL 4308
LE +Q E Q K++A ++ E+++ Q E++ ++ V + K ++Q+ L +L
Sbjct: 1394 AALEKQRQLAEAHAQAKAQAEREAKELQQ-RMQEEVVRREEAAVDAQQQKRSIQEELQQL 1452
Query: 4309 KLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIE 4368
+ S E I + + E A + + + + + L TE + GG ++
Sbjct: 1453 R---QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATE------RQRGGAEGELQ 1503
Query: 4369 IELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEE---ASNLQNKLEVLNQRWQNVL 4425
A+ + Q E + + D + E AS ++ + E ++ Q L
Sbjct: 1504 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREK-QRAL 1562
Query: 4426 EKTEQRKQQLDGALRQAKGFHGEIE---DLQQWLTDTERHL---LASKPLGGLPETAKEQ 4479
+ E+ + Q + A R+ + E+E +Q L +R L SK +TA+ +
Sbjct: 1563 QALEELRLQAEEAERRLR--QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE 1620
Query: 4480 LNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNE 4539
++ E A + +EE + Q+ + AR E E +L
Sbjct: 1621 RSLQEEHVAVAQLREEAERRAQQQAEAERAR--------------------EEAERELER 1660
Query: 4540 RKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEV 4599
+ K EAL L ++ Q +AE+ A R + Q + A +
Sbjct: 1661 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1720
Query: 4600 NSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKR 4659
+ Q+ E GT + + +Q+++ ++ + + + + + L R A ++
Sbjct: 1721 LEKQRQLAE----GTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK 1776
Query: 4660 AKQFHEAWSKL---MEWLEESEKSLDSELEIANDPDK--IKTQLAQHKEFQKSLGAKHSV 4714
++ +K+ ME L S+ + E ++ K ++ + + +E + ++
Sbjct: 1777 RQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRAL 1836
Query: 4715 YDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFT 4774
+ R R L E+ + A + + +L+E G++ + + E AL
Sbjct: 1837 AEEAKRQ-RQLAEEDA-ARQRAEAERVLAEKL----AAIGEATRLKTEAEIALKEKEAEN 1890
Query: 4775 DALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARE 4834
+ L+ L + + + E+Q D+ L KA EL ++ V+ R R+
Sbjct: 1891 ERLRRLAE-DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQ 1949
Query: 4835 L------IEGSRDDSSWVKVQMQ-ELS-TRWETVCALSISKQTRLEAALRQ---AEE--- 4880
+ ++ S + ++ K +++ EL R L +Q LEAA ++ AEE
Sbjct: 1950 VEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERR 2009
Query: 4881 FHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRA-ELNKATTM 4939
+ + LA E+ R ++ + L+ +++ + ++ E++ A +L A
Sbjct: 2010 RREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA 2069
Query: 4940 GDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQ----QRLASALAGLIAKQELLE 4995
L K ++ + +E+ +Q Q Q A A A +E E
Sbjct: 2070 AQKRLQ-------AEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2122
Query: 4996 A-LLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRR 5054
A + A + A++ ++ E + Q EE A+ Q E++ RK+ + + +R
Sbjct: 2123 ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL-RKEAEQEAA----RRA 2177
Query: 5055 AADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGS--------QTQIETKNPRVNLLVSKW 5106
A+ ++L+ D K+F +L + Q+E + + NLL +
Sbjct: 2178 QAEQAALRQK-QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEEL 2236
Query: 5107 QQVWLLALERRRKLNDALDRLEELR 5131
Q++ A E R+ + + L +R
Sbjct: 2237 QRLKAEATEAARQRSQVEEELFSVR 2261
Score = 69.3 bits (168), Expect = 1e-10
Identities = 208/1057 (19%), Positives = 422/1057 (39%), Gaps = 142/1057 (13%)
Query: 4258 KQQIEELKQFKSEAYQQQIEME-------RLNHQAELLLKKVTEESDKHTVQDPLMELKL 4310
K+ E Q +E + Q E+E RL+ +AE +L T++ EL+L
Sbjct: 1040 KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRS---ELEL 1096
Query: 4311 IWDSLEE-RIINRQH--KLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAI 4367
LE+ R ++ + KL+ L + Q A + L A E L E + V +
Sbjct: 1097 TLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAH----EEQLKEAQAVPATLPEL 1152
Query: 4368 EIELAKHHVLQNDVLAHQSTVEAVN------KAGNDLIESSAGE---EASNLQNKLEVLN 4418
E A L+ A Q T +A+ + + ++ GE E + ++ L
Sbjct: 1153 EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLL 1212
Query: 4419 QRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTER--HLLASKPLGGLPETA 4476
+RWQ VL +T+ R+++L+ RQ + + + L WL D R + + PL +
Sbjct: 1213 ERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLAD-SQAV 1271
Query: 4477 KEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETK 4536
+EQL +E+ +++ + + C + A+ Q IN +K+ E +
Sbjct: 1272 REQLR-----------QEQALLEEIERHGEKVEECQRFAK----QYINAIKD----YELQ 1312
Query: 4537 LNERKTKLEEALNLAME------FHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQID 4590
L K +LE + A + + +Q++++ T + + S+ + L +++
Sbjct: 1313 LVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRME 1372
Query: 4591 EHKVFAN-----------EVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRW 4639
E + A EV + E+ +L + K ++++ L + + V R
Sbjct: 1373 EEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRRE 1432
Query: 4640 EKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLA 4699
E V ++ RS+ + ++ +Q EA ++ ++E + S L I + ++ QL
Sbjct: 1433 EAAVDAQQQK-RSIQEELQQLRQSSEA--EIQAKARQAEAAERSRLRIEEEIRVVRLQL- 1488
Query: 4700 QHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVER 4759
+ E Q+ GA+ + R + +K ++ + + +++D+ VE
Sbjct: 1489 EATERQRG-GAEGELQALRARAEEAEAQKRQAQEE---AERLRRQVQDESQRKRQAEVEL 1544
Query: 4760 QNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDID----LVMNLIDNHKAFQ 4815
++++ + + ALQAL + R++ + AE + +++ + + L ++ +
Sbjct: 1545 ASRVKAEAEAAREKQRALQALEE--LRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1602
Query: 4816 KELGKRTSS----VQALKRSARE---LIEGSRDDSSWVKVQMQELS----------TRWE 4858
EL + +S L+RS +E + R+++ Q E RW+
Sbjct: 1603 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ 1662
Query: 4859 TVCALSISKQTRLEAALRQAEEFHSVVHALLE-WLAEAEQTLRFHGVLPDDEDALRTLID 4917
L ++ RL + + S+ A E EAE+ R G + R L +
Sbjct: 1663 ----LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAE 1718
Query: 4918 QHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQ 4977
Q E ++L E A+ A + + + + + AR + A A Q +
Sbjct: 1719 QELEKQRQLAEGTAQQRLAAEQ-ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKR 1777
Query: 4978 QRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEM 5037
Q L + LA + A+ E+L A A + + ++K K+ + E + L EE
Sbjct: 1778 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL-------AEEA 1830
Query: 5038 TRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETKNP 5097
R + ++ K ++ A + ++ Q RA +R A L G T+++T+
Sbjct: 1831 ARLRALAEE-AKRQRQLAEEDAARQ---------RAEAERVLAEKLAAIGEATRLKTEAE 1880
Query: 5098 RVNLLVSKWQQVWLLALERRRKLNDALDRLEELREFANFDFDIWRKKYMRWMNHKKSRVM 5157
+AL+ + N+ L RL E F R++ K+ +
Sbjct: 1881 --------------IALKEKEAENERLRRLAEDEAFQ-------RRRLEEQAAQHKADIE 1919
Query: 5158 DFFRRIDKDQDGKITRQE-FIDGILSSKFPTSRLEMSAVADIFDRDGDGYIDYYEFVAAL 5216
+ ++ K D ++ RQ+ ++ L + E+ A+ F++ G + + +
Sbjct: 1920 ERLAQLRKASDSELERQKGLVEDTLRQRRQVEE-EILALKASFEKAAAGKAELELELGRI 1978
Query: 5217 HPNKDAYKPITDADKIEDEVTRQVAKCKCAKRFQVEQ 5253
N + + ++E RQ+A + +R + E+
Sbjct: 1979 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEE 2015
Score = 40.0 bits (92), Expect = 0.064
Identities = 84/510 (16%), Positives = 207/510 (40%), Gaps = 52/510 (10%)
Query: 1078 EKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQI-RTPLER 1136
+ E+ K++ ++ L+ + EQE + L + E + + L+ RL + +R
Sbjct: 2191 DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR 2250
Query: 1137 DDLHESVFRITEQ----EKLKKELER----------------LKDDLGTITNKCEEFFSQ 1176
+ E +F + Q KLK +E L+++ + EE
Sbjct: 2251 SQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARL 2310
Query: 1177 AAASSSVPTLRSELNVVLQNMNQVYSMSSTYI-DKLKTVNLVLKNTQAAEALVKLYETKL 1235
+ A+ LR + +++ Q +++ + +K++ V + AE L + E
Sbjct: 2311 SVAAQEAARLRQ---LAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ 2367
Query: 1236 CEEEAVIADKNNI-ENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERD 1294
+ + DK + + L + ++ ++ +RQ + E ++ K EM + +
Sbjct: 2368 EQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAE 2427
Query: 1295 LDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQR 1354
D +++A+++ E+ + ++ ++ + + L + I ++E +
Sbjct: 2428 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKE 2487
Query: 1355 KIQ-ENQPENSKTLATQLNQQKMLVSEIE-MKQSKMDEC------QKYAEQYSATVKD-Y 1405
K+Q E + K+ Q QQ+ L+ E + ++QS + E +++ EQ A ++ +
Sbjct: 2488 KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLF 2547
Query: 1406 ELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRY--------------TALV 1451
+ + + + + QQ+ ++++M+ ++ + R R L
Sbjct: 2548 QDEVAKAQQLREEQQR---QQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE 2604
Query: 1452 TLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPF 1511
Q + + +RL E+ + LEE+ + + ++E+ +KTL + A P
Sbjct: 2605 QQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPA 2664
Query: 1512 SKQKISSEEISTKKEQLSEALQTIQLFLAK 1541
++ + +++ ++ LQ + A+
Sbjct: 2665 AEAEPEHSFDGLRRKVSAQRLQEAGILSAE 2694
Score = 35.0 bits (79), Expect = 2.1
Identities = 73/348 (20%), Positives = 135/348 (38%), Gaps = 54/348 (15%)
Query: 4633 ISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLM-------EWLEESEKSLDSEL 4685
+ V+ W K+ ++ER + L +R + +KL E L +++ L S++
Sbjct: 391 LDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDV 450
Query: 4686 -------------EIANDPDKIKTQLAQ-HKEFQKSLGAKHSVYDTTNRTGRSLKEKTSL 4731
E+ D DK + + + Q +H + R L E+
Sbjct: 451 RLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVA 510
Query: 4732 --ADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEP 4789
+ NL+L ++ + + +SV+R+ +LE++ L LQ L+ W+ E
Sbjct: 511 IRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTL------RYLQDLLAWVE--EN 562
Query: 4790 QLAEDQPVHG-DIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSR----DDSS 4844
Q D G D+ V + +H+ + + + + ++ + +L +R D
Sbjct: 563 QHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLG 622
Query: 4845 WVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHAL---LEWLAEAEQTLRF 4901
+ +Q +L L+ SK A LR E HS V A L WL E E+
Sbjct: 623 RLDLQYAKL---------LNSSK-----ARLRSLESLHSFVAAATKELMWLNEKEEE-EV 667
Query: 4902 HGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHP 4949
D + + + M++LE K ++ + GD +L HP
Sbjct: 668 GFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHP 715
Score = 35.0 bits (79), Expect = 2.1
Identities = 22/51 (43%), Positives = 26/51 (50%)
Query: 5433 EDSGLITTAAARVRTQFADSKKTPSRPGSRAGSKAGSRASSRRGSDASDFD 5483
E +GL AA T+ S + S GS AGS+ GSR SR GS FD
Sbjct: 4484 EGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTGSRTGSRAGSRRGSFD 4534
>gi|169218211 PREDICTED: similar to plectin 1, partial [Homo sapiens]
Length = 1369
Score = 667 bits (1721), Expect = 0.0
Identities = 314/717 (43%), Positives = 503/717 (70%)
Query: 641 EEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKI 700
E+ ++++QDLL WV+E Q ++D EWG DLPSVE+ L +H+ +H++IEEF++ ++ A+
Sbjct: 651 EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFQAKIERARS 710
Query: 701 SEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE 760
E Q++ + Y + L RL+ QYAKLLN+S+ + R L++LH+FV+ AT EL+WLNEKEE
Sbjct: 711 DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE 770
Query: 761 EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR 820
EEV +DWS+RNTN+ KK+ ++ LMREL+ KE+ IK +Q ++LL E+HPAR T+E+++
Sbjct: 771 EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 830
Query: 821 AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSI 880
AA+QTQWSW+LQLC C+E H+KEN AYF+FF+D +EA L+ L++A++RK SCDRS+++
Sbjct: 831 AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKNSCDRSATV 890
Query: 881 HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ 940
+LEDL+Q++ +EKE+L +YK ++ L +AK ++QLKPR+ P++ +P+ A+CDY+Q
Sbjct: 891 TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 950
Query: 941 IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ 1000
+E+T++K DEC L + + WKV+S +G+EA VPSVCF VPPPN+E + R+E Q+Q
Sbjct: 951 VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEVQEAVTRLEAQHQ 1010
Query: 1001 NVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFL 1060
++TLWH+ H++MKS+++W L ++ IR+ ++A+ +T+ P E +Q L +L+ ++ FL
Sbjct: 1011 ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 1070
Query: 1061 EDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLE 1120
DSQ++ F D E+E C +YQ+LL+S E+ QEES ISE+++IRL+LE
Sbjct: 1071 RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE 1130
Query: 1121 NCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAAS 1180
CE R + ++R PL+++ E RI EQ+K + E+E L + ++ + E+ + S
Sbjct: 1131 ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1190
Query: 1181 SSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEA 1240
+ PTLRSEL + L + QV S+S+ Y++KLKT++LV++ TQ AE +++ +E +L E +A
Sbjct: 1191 PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1250
Query: 1241 VIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWH 1300
V A +E ++LK+ R++ + ++ F AL DEL+ A+ + + + + + ERD++ +
Sbjct: 1251 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1310
Query: 1301 KEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQ 1357
+E+ QL+ERWQ V Q D R R+LE +G+ L+YYR++ PL W+Q Q +IQ
Sbjct: 1311 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1367
Score = 560 bits (1444), Expect = e-158
Identities = 269/450 (59%), Positives = 360/450 (80%), Gaps = 1/450 (0%)
Query: 71 DERDKVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEVLSGDTLPREKGRMRF 130
DERD+VQKKT TKW+N+HL+K ++H++DLYEDLRDGHNLISLLEVLSGD+LPREKGRMRF
Sbjct: 171 DERDRVQKKTSTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRF 230
Query: 131 HRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIHVTGESED 190
H+LQNVQIALDYL+ RQVKLVNIRNDDI DGNPKLTLGLIWTIILHFQISDI V+G+SED
Sbjct: 231 HKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSED 290
Query: 191 MSAKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAVQSNLA 250
M+AKE+LLLW+Q+ EGY G+RC+NFT+ WRDG+LFNAIIH+++P LIDMN V Q+NL
Sbjct: 291 MTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLE 350
Query: 251 NLEHAFYVAEK-IGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAFPKVPEGGEGIGANDV 309
NL+ AF VAE+ +GV RLLDPEDVDV PDEKS+ITYVSSLYDA P+VP+ +G+ AN++
Sbjct: 351 NLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANEL 410
Query: 310 EVKWIEYQNMVNYLIQWIRHHVTTMSERTFPNNPVELKALYNQYLQFKETEIPPKETEKS 369
+++W EY+ +V L+QW+RHH ER FP++ E++ L++Q+L+FKE E+P KE +K+
Sbjct: 411 QLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKN 470
Query: 370 KIKRLYKLLEIWIEFGRIKLLQGYHPNDIEKEWGKLIIAMLEREKALRPEVERLEMLQQI 429
+ K +Y+ LE ++ G++K+ GYHP D+EKEWGKL +A+LEREK LR E ERLE LQ+I
Sbjct: 471 RSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRI 530
Query: 430 ANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLLRQHVIDVQ 489
++Q ++ +CE++L A LQSD + L +G Q E+ + + ++++R DVQ
Sbjct: 531 VTKLQMEAGLCEEQLHQADALLQSDIRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQ 590
Query: 490 ILIDGKYYQADQLVQRVAKLRDEIMALRNE 519
L DG++ Q +Q+ +RV +L + ++A+R E
Sbjct: 591 TLKDGRHPQGEQMYRRVYRLHERLVAIRTE 620
Score = 44.7 bits (104), Expect = 0.003
Identities = 154/796 (19%), Positives = 310/796 (38%), Gaps = 129/796 (16%)
Query: 3336 QRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRL 3395
QR +L+++ L L+ LL+W+ + + V + + V+AQ+ + L +
Sbjct: 645 QRRPELEDSTLRY------LQDLLAWVEENQHRVDGAEW-GVDLPSVEAQLGSHRGLHQS 697
Query: 3396 LDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGI-S 3454
+++ ++ +E + + +++ PA + L LD ++ LLN ++ R R LE + S
Sbjct: 698 IEEFQAKIERARSDEGQLS----PATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHS 753
Query: 3455 VVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQ 3514
VA E + WL E+ V + + + + + + AL ++ K + +
Sbjct: 754 FVAAATKELM-----WLNEKEEEEVGFD-WSDRNTNMTAKKESYSALMRELELKEKKIKE 807
Query: 3515 AVSIGQSL--KVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGED 3572
+ G L + +R + Q+ L W +LQ C
Sbjct: 808 LQNAGDRLLREDHPARPTVESFQAALQTQWSW-------------MLQLCCC-------- 846
Query: 3573 EVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQ-ALLNGLEL 3631
E H K + Q +S + + + +L+ LQE L RK + D+ A + LE
Sbjct: 847 --------IEAHLKENAAYFQFFS--DVREAEGQLQKLQE-ALRRKNSCDRSATVTRLED 895
Query: 3632 LKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDK 3691
L Q DE +++L K + +AK + +QL R H H
Sbjct: 896 LLQDAQDE----KEQLNEYKGHL-------SGLAKRAKAVVQLKPR-HPAHPMRGRLPLL 943
Query: 3692 VEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVS-SALLELVPWRARE 3750
+ E V KG+E + + K L S +E + ++ LVP +E
Sbjct: 944 AVCDYKQVEVTVHKGDECQLVG------PAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQE 997
Query: 3751 GLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGD 3810
E + + + LV T+ ++ ++L Q + SW T + L
Sbjct: 998 VQEAVTRLEAQHQALV--TLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKP--- 1052
Query: 3811 IRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLK 3870
EQ Q L+ L ++ + D +G E++ +++
Sbjct: 1053 --EEQRQALHSLE---------LHYQAFLRDSQDAG-----GFGPEDRLMAEREYGSCSH 1096
Query: 3871 NYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQ 3930
+Y + Q + + R Q +++ + +L T T + +L P
Sbjct: 1097 HYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRT---VHRLRLPL--------D 1145
Query: 3931 QEEHRQLRELIAEHKPHIDKMNKTGPQLLELS--PGEGFSIQEKYVAADTLYSQIKEDVK 3988
+E R+ + IAE + ++ G + LS + ++ E AA TL S+++ +
Sbjct: 1146 KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLG 1205
Query: 3989 KRAVALDEAISQSTQFHDKIDQIL----------ESLERIVERLRQPPSISAEVEKIKEQ 4038
K L++ S S + +K+ I E L E+L++ ++ A + +++
Sbjct: 1206 K----LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEAT 1261
Query: 4039 ISENKNVSVDMEKLQPLYETLKQR-------GEEMIARSGGTDKDISAKAVQDKLDQMVF 4091
+ K + E QP ++ L+ GE + R G ++D+ + ++++ Q++
Sbjct: 1262 KASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHG--ERDVEVERWRERVAQLLE 1319
Query: 4092 IWENIHTLVEEREAKL 4107
W+ + + R+ +L
Sbjct: 1320 RWQAVLAQTDVRQREL 1335
Score = 41.6 bits (96), Expect = 0.022
Identities = 60/296 (20%), Positives = 122/296 (41%), Gaps = 35/296 (11%)
Query: 3201 DLVGIKRDLEALSKQCNKLLDRAQ--AREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHE 3258
D + +R+ + S +LL + A+EE R + S+LK+ + L+ E
Sbjct: 1083 DRLMAEREYGSCSHHYQQLLQSLEQGAQEES------RCQRCISELKDIRLQLEACETRT 1136
Query: 3259 ESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAK--------- 3309
+ + ++ E + + I Q Q +V LG+G+ + +A+
Sbjct: 1137 VHRLRLPLDKEPARECA--------QRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPE 1188
Query: 3310 -STSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEEL 3368
S + L +L+ + + + A +L+ L Q A E L + +E
Sbjct: 1189 PSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEA 1248
Query: 3369 VA------NQKPPSAEFKVVKAQIQ-EQKLLQRLLDDRKSTVEVIKREGEKIATTAEPAD 3421
A + A K ++AQ + +Q L D+ + EV +R ++ +
Sbjct: 1249 QAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVE 1308
Query: 3422 KVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKR 3477
+ + ++++ L RW+A+L + + R R+LE + + + E+ +PL WL +R
Sbjct: 1309 RWR--ERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRR 1362
Score = 40.4 bits (93), Expect = 0.049
Identities = 56/223 (25%), Positives = 95/223 (42%), Gaps = 26/223 (11%)
Query: 4258 KQQIEELKQFKSEAYQQQIEME-------RLNHQAELLLKKVTEESDKHTVQDPLMELKL 4310
K+ E Q +E + Q E+E RL+ +AE +L T++ EL+L
Sbjct: 1146 KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRS---ELEL 1202
Query: 4311 IWDSLEE-RIINRQH--KLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAI 4367
LE+ R ++ + KL+ L + Q A + L A E L E + V +
Sbjct: 1203 TLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAH----EEQLKEAQAVPATLPEL 1258
Query: 4368 EIELAKHHVLQNDVLAHQSTVEAVN------KAGNDLIESSAGE---EASNLQNKLEVLN 4418
E A L+ A Q T +A+ + + ++ GE E + ++ L
Sbjct: 1259 EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLL 1318
Query: 4419 QRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTER 4461
+RWQ VL +T+ R+++L+ RQ + + + L WL D R
Sbjct: 1319 ERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARR 1361
Score = 38.9 bits (89), Expect = 0.14
Identities = 33/147 (22%), Positives = 67/147 (45%), Gaps = 5/147 (3%)
Query: 2451 LGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKT-ATKWQQTPAPTDTEAVKTQV 2509
L + +K+ ++ + Q A+E A + L++ AT + + ++ Q
Sbjct: 1213 LSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQA 1272
Query: 2510 E-QNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTI 2568
E Q +F+A L+ + QE+ ++L + E E RW++ + ++ +WQ + T
Sbjct: 1273 EAQQPTFDA-LRDELRGAQEVGERLQQRHGERD--VEVERWRERVAQLLERWQAVLAQTD 1329
Query: 2569 DRQQKLEESSNNLTQFQTVEAQLKQWL 2595
RQ++LE+ L ++ L WL
Sbjct: 1330 VRQRELEQLGRQLRYYRESADPLGAWL 1356
Score = 35.4 bits (80), Expect = 1.6
Identities = 73/348 (20%), Positives = 135/348 (38%), Gaps = 54/348 (15%)
Query: 4633 ISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLM-------EWLEESEKSLDSEL 4685
+ V+ W K+ ++ER + L +R + +KL E L +++ L S++
Sbjct: 497 LDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLHQADALLQSDI 556
Query: 4686 -------------EIANDPDKIKTQLAQ-HKEFQKSLGAKHSVYDTTNRTGRSLKEKTSL 4731
E+ D DK + + + Q +H + R L E+
Sbjct: 557 RLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVA 616
Query: 4732 --ADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEP 4789
+ NL+L ++ + + +SV+R+ +LE++ L LQ L+ W+ E
Sbjct: 617 IRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTL------RYLQDLLAWVE--EN 668
Query: 4790 QLAEDQPVHG-DIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSR----DDSS 4844
Q D G D+ V + +H+ + + + + ++ + +L +R D
Sbjct: 669 QHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFQAKIERARSDEGQLSPATRGAYRDCLG 728
Query: 4845 WVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHAL---LEWLAEAEQTLRF 4901
+ +Q +L L+ SK A LR E HS V A L WL E E+
Sbjct: 729 RLDLQYAKL---------LNSSK-----ARLRSLESLHSFVAAATKELMWLNEKEEE-EV 773
Query: 4902 HGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHP 4949
D + + + M++LE K ++ + GD +L HP
Sbjct: 774 GFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHP 821
Score = 34.7 bits (78), Expect = 2.7
Identities = 77/390 (19%), Positives = 150/390 (38%), Gaps = 56/390 (14%)
Query: 2585 QTVEAQLKQWLVEKELMVSVLGPLSIDPNML---NTQRQQVQIL----LQEFATRKPQYE 2637
Q V+ + + + + +V++ L +D L + R+ VQ++ L F T KP+ +
Sbjct: 996 QEVQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQ 1055
Query: 2638 Q-----LTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKS 2692
+ L Q L R +D G E +++ G S + Q++ +
Sbjct: 1056 RQALHSLELHYQAFL-RDSQDAG--GFGPEDRLMAEREY----GSCSHHYQQLLQSLEQG 1108
Query: 2693 TQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEI-QQEKKQIKVA- 2750
Q +S + +L D+ +L + + H + E A++ Q I +Q+K Q +V
Sbjct: 1109 AQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEG 1168
Query: 2751 --------QALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASS 2802
A E + AL + L +LE L + V + +++ L++
Sbjct: 1169 LGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVI 1228
Query: 2803 HQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIA 2862
Q +A + KE Q + A L LE+ K K L AQ+ + T
Sbjct: 1229 RGTQGAEEVLRAHEEQLKEAQ----AVPATLPELEAT----KASLKKLRAQAEAQQPTF- 1279
Query: 2863 EGENLLLKTQGSEKAALQLQ----------------LNTIKTNWDTFNKQVKERENKLKE 2906
+ L + +G+++ +LQ + + W Q R+ +L++
Sbjct: 1280 --DALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1337
Query: 2907 SLEKALKYKEQVETLWPWIDKCQNNLEEIK 2936
+ Y+E + L W+ + E+I+
Sbjct: 1338 LGRQLRYYRESADPLGAWLQDARRRQEQIQ 1367
>gi|58530840 desmoplakin isoform I [Homo sapiens]
Length = 2871
Score = 609 bits (1571), Expect = e-173
Identities = 460/1803 (25%), Positives = 884/1803 (49%), Gaps = 168/1803 (9%)
Query: 641 EEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKI 700
+E + L W+ + + ++D WG DL SVE H+ +H+ +H +I ++ L + K
Sbjct: 181 DEFTKHVTSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKA 240
Query: 701 SEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE 760
+ +A +++LE +Y LL S + HL L N + + E++W+N+ EE
Sbjct: 241 DLREKSA---------IYQLEEEYENLLKASFERMDHLRQLQNIIQATSREIMWINDCEE 291
Query: 761 EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR 820
EE+ YDWS++NTNIA+K++ + M +L+ KE+ + +++ ++QL+L HPA IEAY
Sbjct: 292 EELLYDWSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYM 351
Query: 821 AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSI 880
+QTQWSWILQ+ +C++ H+KEN AYF+FF +A+ YL+ L+D+I++KY CD++ +
Sbjct: 352 DTLQTQWSWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPL 411
Query: 881 HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ 940
L + ++E +E+E++L+YK + NL+ K+K I+QLKPRN D I ++A+CDY+Q
Sbjct: 412 QHLLEQIKELEKEREKILEYKRQVQNLVNKSKKIVQLKPRNPDYRSNKPIILRALCDYKQ 471
Query: 941 IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ 1000
+ ++K DEC+L +N+ R+KW V P G + +VPSV +PPPN AVDL+ +IEQ Y+
Sbjct: 472 DQKIVHKGDECILKDNNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYYE 531
Query: 1001 NVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFL 1060
+L LW++ +INMKS+VSWHY + +I++IRA +A +KTM ++ + +++L+ +++F+
Sbjct: 532 AILALWNQLYINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFI 591
Query: 1061 EDSQESQVFSGSDITQLEKEVNVCKQYYQELL---------------------------- 1092
+SQ S++F D +++ + +++YQ L+
Sbjct: 592 RNSQGSEMFGDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQDVNH 651
Query: 1093 -KSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEK 1151
K E + + + E++ IR ++E+CE R+ + ++ H +I E +
Sbjct: 652 NKVIETNRENDKQETWMLMELQKIRRQIEHCEGRMTLKNLPLADQGSSHHITVKINELKS 711
Query: 1152 LKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKL 1211
++ + + + + + N+ ++ + S L++E+ + Q + + ++ Y++ L
Sbjct: 712 VQNDSQAIAE----VLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSL 767
Query: 1212 KTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHA 1271
TV +L+ E ++K+YE +L EEE V D + +E LK+ +++++ K+ +
Sbjct: 768 CTVRALLQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLAT 827
Query: 1272 LEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKS 1331
++ ELQKA+ I + + Y DLD EK QL +RWQ + QID RL DLE K
Sbjct: 828 MKTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQ 887
Query: 1332 LKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDEC 1391
L+ YRD Y W+ + Q ++ + +S T+ LN+QK L SEI K+ K +E
Sbjct: 888 LRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEV 947
Query: 1392 QKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALV 1451
QK AE + ++KDYELQ +Y + +++ P+KR +QS + +I+QE D+ RY L+
Sbjct: 948 QKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELL 1007
Query: 1452 TLMTQYIKFAGDSLKRLE------------EEE---------------KSLEEEKKEHVE 1484
T Y +F + LK LE EEE K L++ +++
Sbjct: 1008 TRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQA 1067
Query: 1485 KAKELQKWVSNISKTLKDAEKAGKPPFSKQKISS-----EEISTKKEQLSEALQTIQLFL 1539
+ + + ++++ + + AE GK +KQ + +E++ K +L+ ++ +
Sbjct: 1068 ECSQFKAKLASLEELKRQAELDGKS--AKQNLDKCYGQIKELNEKITRLTYEIED-EKRR 1124
Query: 1540 AKHGDKMTDEERNELEKQVKTLQ-ESYNLLFS--ESLKQLQESQTSGD-VKVEEKIVAER 1595
K + D+++N+ ++ K Q E NL + ES K ++E + + ++V + R
Sbjct: 1125 RKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTR 1184
Query: 1596 QQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALA 1655
++EY+ +L + + + + L E I +K+ ++E+ K+++ L+
Sbjct: 1185 KREYENELAKVRNHYNEEMSNLRNKYET-EINITKTTIKEISMQKEDDSKNLRNQLDRLS 1243
Query: 1656 --------EVVKNTENFLKENGEKLSQEDKAL--------IEQKLNEAKIKCEQL----- 1694
E+V+ ++ L+ ++ E+ AL I QK +I+ +Q+
Sbjct: 1244 RENRDLKDEIVRLNDSILQATEQRRRAEENALQQKACGSEIMQKKQHLEIELKQVMQQRS 1303
Query: 1695 --NLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGT 1752
N + +QS +E K + KE A ++ + + + EN L + N + D E
Sbjct: 1304 EDNARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKVRN-NYDEEIISL 1362
Query: 1753 KHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQEN--LNQQYQKVK-- 1808
K++ E N T + + + +E++ +G + D T+EN L+++ +++K
Sbjct: 1363 KNQFETEINIT--KTTIHQLTMQKEEDTSGYRAQID-----NLTRENRSLSEEIKRLKNT 1415
Query: 1809 -AQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEK 1867
Q + + + + I ++ + ++ Q L E ++ Q +E V Y+ +L ++ K
Sbjct: 1416 LTQTTENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQVTQMRTEE-SVRYKQSLDDAAK 1474
Query: 1868 KMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDV 1927
++ + E L++ T L+ L+ ++ N T+ + E
Sbjct: 1475 TIQDKNKEIERLKQLIDKETNDRKCLEDENARLQRVQYDLQKANSSATETINKLKVQEQ- 1533
Query: 1928 ISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQR-KLDHATDRFRSLYSKC 1986
+L + I RV + ++ +D + S ++Q+ K++ +R + S+
Sbjct: 1534 -----ELTRLRIDYERVSQ-ERTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRTASED 1587
Query: 1987 NVLGNNLKDLVDKYQHYEDASCGLLAGL--QACEATASKHLSEPIAVDPKNLQRQLEETK 2044
+ L++ ++ G+ L QA + T E ++ K + L + +
Sbjct: 1588 SCKRKKLEEELE----------GMRRSLKEQAIKITNLTQQLEQASIVKKRSEDDLRQQR 1637
Query: 2045 -ALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKT---LDDIVGRYEDLSKSVN 2100
L G + +Q E+L++ + + R LL + +++ + ED S+S+N
Sbjct: 1638 DVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLN 1697
Query: 2101 ERN---EKLQITLTRSLSVQD-GLDEMLDWMGNVESSL---KEQGQVPLNSTAL----QD 2149
E E+LQ +LT +L+ + L+E L + L + + N+T L Q
Sbjct: 1698 ESKIEIERLQ-SLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSDKNATILELRSQL 1756
Query: 2150 IISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHK 2209
IS N LE + G + + E +++ +E Q + + S R E+ ++
Sbjct: 1757 QISNNRTLE--LQGLINDLQRERENLRQEIE--------KFQKQALEASNRIQESKNQCT 1806
Query: 2210 ETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLE 2269
+ + + E L K+++ E +LQ + +A + ++ + L Q+ ++ +
Sbjct: 1807 QVVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQ 1866
Query: 2270 HKKHLEVLHSLLKEISSHGLPS--DKALVLEKTNNLSKKFKEMEDTIKEKKEAVT-SCQE 2326
K +++I S S +K + + L + K +E+ + K E T Q
Sbjct: 1867 WKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLEDSTRETQS 1926
Query: 2327 QLD 2329
QL+
Sbjct: 1927 QLE 1929
Score = 90.5 bits (223), Expect = 4e-17
Identities = 231/1243 (18%), Positives = 489/1243 (39%), Gaps = 199/1243 (16%)
Query: 3305 QSAAKSTSTQGLEHDLD---------DVNARWKTLNKKVAQRAAQLQEALLHCGRFQDAL 3355
Q TS Q +DLD + RW+ ++K++ R L++ + ++D
Sbjct: 836 QQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNY 895
Query: 3356 ESLLSWMVDTEELVAN-QKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIA 3414
++ W+ D + + + + V + EQK L + ++ E +++ E A
Sbjct: 896 QAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELCA 955
Query: 3415 TTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQ-------FHETLEPL 3467
+ + + QL+ S E LLN R V+ Q+ + E L
Sbjct: 956 NSIKDYE-----LQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLTRS 1010
Query: 3468 NEWLTTIEKRLVNCEPI---GTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKV 3524
++ + + L + E + T+ LEE++ + + N NK L
Sbjct: 1011 GDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFL------------ 1058
Query: 3525 LSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVH 3584
D+++ + + + SQ + K S EL +QA + K ++ + + E++
Sbjct: 1059 -----DQNLQKYQAECSQ-----FKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELN 1108
Query: 3585 DKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQ 3644
+K+++L+ Y E + R ED +++N L + K+ G + L
Sbjct: 1109 EKITRLT---YEIE----DEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKL--- 1158
Query: 3645 DKLEAIKARYKDITK----LSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYE 3700
+ +AIK + +I + L + + E +LA+ + +EE+ +K E E+ +
Sbjct: 1159 ESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYNEEMSNLRNKYETEINITK 1218
Query: 3701 TQV--LKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAE 3758
T + + ++ ++ +L + ++ N+ L D + ++ ++L+ R R AE
Sbjct: 1219 TTIKEISMQKEDDSKNLRNQLDRLSRENRDLKDEIVRLNDSILQATEQRRR-------AE 1271
Query: 3759 DNE-RYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQ 3817
+N + + I QK + ++ + Q Q ++ E+ ++ D E ++
Sbjct: 1272 ENALQQKACGSEIMQKKQHLEIEL--KQVMQQRSEDNARHKQSLEEAAKTIQDKNKEIER 1329
Query: 3818 TSAQLQ---------------VQKTFTMEILRHKDIID---DLVKSGHKIMTACSEEEKQ 3859
A+ Q V+ + EI+ K+ + ++ K+ +T EE+
Sbjct: 1330 LKAEFQEEAKRRWEYENELSKVRNNYDEEIISLKNQFETEINITKTTIHQLTMQKEEDTS 1389
Query: 3860 SMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPA 3919
+ ++D + + ++ + +++R ++ + Q E L + I Q A
Sbjct: 1390 GYRAQIDNLTRENRSLSE-------EIKRLKNTLTQTTEN-------LRRVEEDIQQQKA 1435
Query: 3920 PALEYETLRQQQE-EHRQLRELIAE----HKPHIDKMNKTGPQLLELSPGEGFSIQEKYV 3974
E +QQ E E RQ+ ++ E +K +D KT IQ+K
Sbjct: 1436 TGSEVSQRKQQLEVELRQVTQMRTEESVRYKQSLDDAAKT--------------IQDKNK 1481
Query: 3975 AADTLYSQIKEDVKKRAVALDE-AISQSTQFHDKIDQILESLERIVERLRQPPSISAEVE 4033
+ L I ++ R DE A Q Q+ + + S + +L+ +
Sbjct: 1482 EIERLKQLIDKETNDRKCLEDENARLQRVQY--DLQKANSSATETINKLKVQEQELTRLR 1539
Query: 4034 KIKEQISENKNV-SVDMEKLQPLYETL---KQRGEEMIARSGGTDKDISAKAVQDKLDQM 4089
E++S+ + V D+ + Q + L KQ+ EE + R T + S K + KL++
Sbjct: 1540 IDYERVSQERTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCK--RKKLEEE 1597
Query: 4090 VFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVK 4149
+ E + ++E+ K+ ++ + E+ + K ++D +R D +D + +
Sbjct: 1598 L---EGMRRSLKEQAIKITNLTQQLEQ-------ASIVKKRSEDDLRQQRDV-LDGHLRE 1646
Query: 4150 QQ--QEAAETIREEIDGLQEEL----DIV--INLGSELIAACGEPDKPIVKKSIDELNSA 4201
+Q QE + E++ L+ +L + V +L +E E + +S E+
Sbjct: 1647 KQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNESKIEIERL 1706
Query: 4202 WDSLNKAWKDRIDKLEEAMQAAVQYQD--------------GLQAVFDWVDIAGGKLASM 4247
K+ + EE ++Y D + + + I+ + +
Sbjct: 1707 QSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSDKNATILELRSQLQISNNRTLEL 1766
Query: 4248 SPIGTDLETVKQQI-EELKQFKSEAYQQQIEMERLNHQA--------ELLLKKVTEESDK 4298
+ DL+ ++ + +E+++F+ +A + ++ +Q LL+K E DK
Sbjct: 1767 QGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQVVQERESLLVKIKVLEQDK 1826
Query: 4299 HTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQK 4358
+Q EL +LE +Q +LE + Q ++L W T +
Sbjct: 1827 ARLQRLEDELNRAKSTLEAETRVKQ-RLE------CEKQQIQNDLNQWKTQYSRKEEAIR 1879
Query: 4359 PVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLN 4418
+ + + E E + L++++ Q+ ++ + + +E S E Q++LE
Sbjct: 1880 KIESEREKSERE---KNSLRSEIERLQAEIKRIEERCRRKLEDSTRE----TQSQLETER 1932
Query: 4419 QRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTER 4461
R+Q ++K QR G H E + +W DT +
Sbjct: 1933 SRYQREIDKLRQRPY----------GSHRETQTECEWTVDTSK 1965
Score = 70.9 bits (172), Expect = 3e-11
Identities = 245/1257 (19%), Positives = 493/1257 (39%), Gaps = 214/1257 (17%)
Query: 2433 GLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMM--------QWLQ 2484
GL IK D+ L K +A + T+L K Q+ ++S ++ +
Sbjct: 810 GLKKIKNDLN-----------LKKSLLATMKTELQKAQQIHSQTSQQYPLYDLDLGKFGE 858
Query: 2485 KMNKTATKWQQTPAPTDTEA--VKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEEN-P 2541
K+ + +WQ+ D ++ Q++Q +++ + + + K + L
Sbjct: 859 KVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFG 918
Query: 2542 DTPEAPRW----KQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVE 2597
D+ R+ K + +EI K + ++ QK+ E N + E QL +
Sbjct: 919 DSNTVMRFLNEQKNLHSEISGKRDKSEEV-----QKIAELCAN--SIKDYELQLASYTSG 971
Query: 2598 KELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQY-EQLTAAGQ-----GILSRPG 2651
E ++++ P + ++LQE A +Y E LT +G + +
Sbjct: 972 LETLLNI-------PIKRTMIQSPSGVILQEAADVHARYIELLTRSGDYYRFLSEMLKSL 1024
Query: 2652 EDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVK----STQYQSLLRSLSD--K 2705
ED L+ E L + + ++ ++DQ + K +Q+++ L SL + +
Sbjct: 1025 EDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEELKR 1084
Query: 2706 LSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEY 2765
++LD K S+ + + + E ++ EI+ EK++ K ED K +Y
Sbjct: 1085 QAELDGK-SAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSV----EDRFDQQKNDY 1139
Query: 2766 LKAELSRQLEGI------LKSFKDVEQKAENHVQHL----------------QSACASSH 2803
+ + +RQ E L+S K +++K E ++ L + A +H
Sbjct: 1140 DQLQKARQCEKENLGWQKLESEKAIKEK-EYEIERLRVLLQEEGTRKREYENELAKVRNH 1198
Query: 2804 QFQQMSR---DFQAWLDTKK--------EEQNKSHPISAKLDVLESLIKDHKDFSKTLTA 2852
++MS ++ ++ K ++++ S + +LD L +D KD L
Sbjct: 1199 YNEEMSNLRNKYETEINITKTTIKEISMQKEDDSKNLRNQLDRLSRENRDLKDEIVRLND 1258
Query: 2853 Q--SHMYEKTIAEGENLLLKTQGSE----KAALQLQLNTIKTNWDTFNKQVKER------ 2900
++ AE L K GSE K L+++L + N + K+
Sbjct: 1259 SILQATEQRRRAEENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEAAK 1318
Query: 2901 --ENKLKESLEKALKYKEQVETLWPW---IDKCQNNL-EEIKFCLDPAEGENSIAKLK-- 2952
++K KE +++E+ + W + + K +NN EEI + E E +I K
Sbjct: 1319 TIQDKNKEIERLKAEFQEEAKRRWEYENELSKVRNNYDEEIISLKNQFETEINITKTTIH 1378
Query: 2953 --SLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFC 3010
++QKE D ++ N +T EN+SL +++ + L
Sbjct: 1379 QLTMQKEEDTSGYRAQIDN----------------LTRENRSLSEEIKRLKNTLTQTT-- 1420
Query: 3011 LENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKH 3070
EN+ + ++ Q+ K + ++ K+QL++ +Q + + + Q+ + + ++
Sbjct: 1421 -ENLRRVEEDIQQ-QKATGSEVSQRKQQLEVELRQVTQMRTEESVRYKQSLDDAAKTIQD 1478
Query: 3071 QVDLAKRLAQDLVVEASDSKGTSDVLLQVETI-------------------AQEHSTLSQ 3111
+ +RL Q + E +D K D +++ + QE
Sbjct: 1479 KNKEIERLKQLIDKETNDRKCLEDENARLQRVQYDLQKANSSATETINKLKVQEQELTRL 1538
Query: 3112 QVD-EKCSFLET-KLQGIGHFQNTIREMFSQFAEFDDELDSM-APVGRDAETLQKQKETI 3168
++D E+ S T K Q I FQN+++E+ Q + ++EL+ + D+ +K +E +
Sbjct: 1539 RIDYERVSQERTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEEL 1598
Query: 3169 KAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRD---------------LEALS 3213
+ + L+ N + + ++ S D + +RD L LS
Sbjct: 1599 EGMRRSLKEQAIKITNLTQQLEQASIVKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLS 1658
Query: 3214 KQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEE---------SQGPV 3264
+ L + +E V+ R E F +++ S L +++ E ++ +
Sbjct: 1659 SEVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNESKIEIERLQSLTENLTKEHL 1718
Query: 3265 GMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDL---- 3320
+E E N +L + ++ E K + L L S ++ QGL +DL
Sbjct: 1719 MLEEELRNLRLE-YDDLRRGRSEADSDKNATILELRSQLQISNNRTLELQGLINDLQRER 1777
Query: 3321 DDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFK 3380
+++ + K+ + + ++QE+ C + ESLL + K
Sbjct: 1778 ENLRQEIEKFQKQALEASNRIQESKNQCTQVVQERESLL-----------------VKIK 1820
Query: 3381 VVKAQIQEQKLLQRLLDD---RKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWE 3437
V++ Q++ LQRL D+ KST+E R +++ E L Q SR E
Sbjct: 1821 VLE---QDKARLQRLEDELNRAKSTLEAETRVKQRL--ECEKQQIQNDLNQWKTQYSRKE 1875
Query: 3438 ALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQ--ASKLEEQI 3495
+ K E+ + E +E L + IE+R T+ S+LE +
Sbjct: 1876 EAIRKIESEREKSER---EKNSLRSEIERLQAEIKRIEERCRRKLEDSTRETQSQLETER 1932
Query: 3496 AQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKS 3552
++++ D + H+ V +S+ D ++ K+ Q++ ++ +K+
Sbjct: 1933 SRYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKVTAMQLYECQLIDKT 1989
Score = 70.1 bits (170), Expect = 6e-11
Identities = 302/1685 (17%), Positives = 650/1685 (38%), Gaps = 262/1685 (15%)
Query: 1090 ELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERD-DLHESVFRITE 1148
++ K + +E + Y + E ++ L+ +D + ++ P +++ L + +I E
Sbjct: 363 QITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKY--PCDKNMPLQHLLEQIKE 420
Query: 1149 QEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNM----------- 1197
EK ++++ K + + NK ++ + P RS ++L+ +
Sbjct: 421 LEKEREKILEYKRQVQNLVNKSKKIVQLKPRN---PDYRSNKPIILRALCDYKQDQKIVH 477
Query: 1198 -------------NQVYSMSSTYIDKL-KTVNLVLK--NTQAAEALVKLYETKLCEEEAV 1241
++ Y +D L +V L++ N A + K+ + EA+
Sbjct: 478 KGDECILKDNNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYY----EAI 533
Query: 1242 IADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDL-----D 1296
+A N + + +L W H +++K +A++ KT ++ D D
Sbjct: 534 LALWNQLYINMKSLVSW-----------HYCMIDIEKIRAMTIAKLKTMRQEDYMKTIAD 582
Query: 1297 FDWHKEKADQLVERWQNVHVQIDNRLRDLEG-IGKSLKYYRDTYHPLDDWIQQ--VETTQ 1353
+ H + + + Q + D+ R ++ + K+Y+ L + Q V TT+
Sbjct: 583 LELHYQ---EFIRNSQGSEMFGDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTE 639
Query: 1354 ------------RKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMD-ECQKYAEQYSA 1400
K+ E EN K L + + + +IE + +M + A+Q S+
Sbjct: 640 ITHHGTCQDVNHNKVIETNRENDKQETWMLMELQKIRRQIEHCEGRMTLKNLPLADQGSS 699
Query: 1401 ---TVKDYELQTMTYR----AMVDSQQKSPVKRRR-------MQSSADLIIQEFMDLR-- 1444
TVK EL+++ A V +Q K + R +Q+ + Q+ ++
Sbjct: 700 HHITVKINELKSVQNDSQAIAEVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGV 759
Query: 1445 ----TRYTALVTLMTQYIKFAGDSLK----RLEEEEK-SLEEEKKEHVEKAKELQKWVSN 1495
V + Q I D LK RL EEE L+ +K E + K N
Sbjct: 760 TDGYLNSLCTVRALLQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLN 819
Query: 1496 ISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTD--EERNE 1553
+ K+L + K ++ Q S+ L L K G+K+T +
Sbjct: 820 LKKSL----------LATMKTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQR 869
Query: 1554 LEKQVKTLQESYNLL-FSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQ 1612
++KQ+ + L + +KQL+ Y++ Q C L
Sbjct: 870 IDKQI-----DFRLWDLEKQIKQLRN--------------------YRDNYQAFCKWLYD 904
Query: 1613 TENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTE---NFLKENG 1669
+ R E+ GD ++ + ++Q+ L ++ G EV K E N +K+
Sbjct: 905 AKRRQ-DSLESMKFGDSNTVMR-FLNEQKNLHSEISGKRDKSEEVQKIAELCANSIKDYE 962
Query: 1670 EKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEET----------EK 1719
+L+ L + L IK + + +E V I+ T E
Sbjct: 963 LQLASYTSGL--ETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLTRSGDYYRFLSEM 1020
Query: 1720 VAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQE--GDGKSAIGEE 1777
+ +++ L+ TKIE L + L + +D+ + ++QN +Q K+ +
Sbjct: 1021 LKSLEDLKLKNTKIEVLEEEL-RLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASL 1079
Query: 1778 DEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQ 1837
+E+ + ++DG+ + ++NL++ Y ++K +EKI + + + + ++ Q
Sbjct: 1080 EELKR---QAELDGK--SAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQ 1134
Query: 1838 YLSPEEKEKLQK-------NMKELKVHYETALAESEKKM-KLTHSLQEELEKFDADYTEF 1889
+ ++LQK N+ K+ E A+ E E ++ +L LQEE + E
Sbjct: 1135 --QKNDYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENEL 1192
Query: 1890 EHWLQQSEQELENLEAGAD-DINGLMTKLKRQKSFSED-----------VISHKGDLR-Y 1936
+E+ NL + +IN T +K ED + DL+
Sbjct: 1193 AKVRNHYNEEMSNLRNKYETEINITKTTIKEISMQKEDDSKNLRNQLDRLSRENRDLKDE 1252
Query: 1937 ITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDL 1996
I + +L+A + + + + A E+ +K H + V+ +D
Sbjct: 1253 IVRLNDSILQATEQRRRAEENALQQKACGSEIMQKKQHLEIELKQ------VMQQRSEDN 1306
Query: 1997 VDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVA 2056
Q E+A+ + +K + A + +R+ E L ++
Sbjct: 1307 ARHKQSLEEAAKTI--------QDKNKEIERLKAEFQEEAKRRWEYENELSKVRNNYDEE 1358
Query: 2057 VEKLKKTAEVLLDARGSLLPAKNDIQKTLDDI-----VGRYEDLSKSVNERNEKLQITLT 2111
+ LK E ++ + + +QK D + ++S++E ++L+ TLT
Sbjct: 1359 IISLKNQFETEINITKTTIHQLT-MQKEEDTSGYRAQIDNLTRENRSLSEEIKRLKNTLT 1417
Query: 2112 RSLSVQDGLDEMLDWM---GNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSI 2168
++ ++E + G+ S K+Q +V L Q +++ +Q + +I
Sbjct: 1418 QTTENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQVT-QMRTEESVRYKQSLDDAAKTI 1476
Query: 2169 NAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENL 2228
N+++++ + D T + ++D +AR + ++ + E K+++ E
Sbjct: 1477 QDKNKEIERLKQLIDKETND--RKCLEDENARLQRVQYDLQKANSSATETINKLKVQEQE 1534
Query: 2229 SEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHG 2288
+L+ E +Q T D +D+T ++E L+ +K E L+ L + S
Sbjct: 1535 LTRLRIDYERVSQERTVKD---QDITRFQNSLKELQ---LQKQKVEEELNRLKRTASEDS 1588
Query: 2289 LPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKK 2348
K L ++ + M ++KE+ +T+ +QL+ ++ K + +++
Sbjct: 1589 C---------KRKKLEEELEGMRRSLKEQAIKITNLTQQLEQASIVKKRSEDDLRQQRDV 1639
Query: 2349 VP--IVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAI 2406
+ + + E+L + + + L+ + E + V + + + A+ ++++
Sbjct: 1640 LDGHLREKQRTQEELRRLSSEVEALRRQ---LLQEQESVKQAHLRNEHFQKAIEDKSRSL 1696
Query: 2407 AAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLG-------LLLKDKI 2459
K L E + L +++ + D+ G + L L+ ++
Sbjct: 1697 NESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSDKNATILELRSQL 1756
Query: 2460 AELNTKLSKLQ----KAQEESSAMMQWLQKMNKTA---------TKWQQTPAPTDTEAVK 2506
N + +LQ Q E + Q ++K K A +K Q T + E++
Sbjct: 1757 QISNNRTLELQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQVVQERESLL 1816
Query: 2507 TQV---EQNKSFEAELKQNVNKVQELKDKLTEL-----LEENPDTPEAPRWKQMLTEIDS 2558
++ EQ+K+ L+ +N+ + + T + E+ + +WK T+
Sbjct: 1817 VKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWK---TQYSR 1873
Query: 2559 KWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQ 2618
K + + ++ +R++ E ++ ++ + ++A++K+ +E+ + + L T+
Sbjct: 1874 KEEAIRKIESEREKSEREKNSLRSEIERLQAEIKR--IEERCRRKLEDSTRETQSQLETE 1931
Query: 2619 RQQVQ 2623
R + Q
Sbjct: 1932 RSRYQ 1936
Score = 66.6 bits (161), Expect = 6e-10
Identities = 234/1283 (18%), Positives = 498/1283 (38%), Gaps = 200/1283 (15%)
Query: 3619 QNVDQALLNGLELLKQTTG-----DEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQ 3673
QN QA+ L LK ++ +Q+++ + + ++I ++ +L
Sbjct: 713 QNDSQAIAEVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSLCTVRA 772
Query: 3674 LARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSL 3733
L + + T + L + E L ET L ++ + K++K + K+LL ++
Sbjct: 773 LLQAILQTEDMLKVY----EARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATM 828
Query: 3734 N-------EVSSALLELVPWRARE--GLEKMVAEDNERYRLVSDTITQKVEEIDAAILRS 3784
++ S + P + + V + +R++ + I ++ +++ I +
Sbjct: 829 KTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQL 888
Query: 3785 QQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQ-LQVQKTFTMEILRHKDIIDDLV 3843
+ + A W+ + +++ SL ++ T + L QK EI +D +++
Sbjct: 889 RNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQ 948
Query: 3844 KSGHKIMTACSEEEKQ--SMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYE 3901
K + + E Q S L+ +L I S + L+ A + ++ E
Sbjct: 949 KIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLT 1008
Query: 3902 ELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLEL 3961
+ ++ L L+ + +EE R R+ +E+ NK Q L+
Sbjct: 1009 RSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENC----NKNKFLDQNLQK 1064
Query: 3962 SPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLE----- 4016
E + K + + L Q + D K LD+ Q + ++KI ++ +E
Sbjct: 1065 YQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRR 1124
Query: 4017 --RIVERLRQPPSISAEVEKIKEQISEN------------KNVSVDMEKLQPLYE---TL 4059
+ +R Q + +++K ++ EN K ++E+L+ L + T
Sbjct: 1125 RKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTR 1184
Query: 4060 KQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWEN----IHTLVEEREAKLLDVMELAE 4115
K+ E +A+ + + +++K + + I + I E+ L + ++
Sbjct: 1185 KREYENELAKVRNHYNEEMSN-LRNKYETEINITKTTIKEISMQKEDDSKNLRNQLDRLS 1243
Query: 4116 KFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINL 4175
+ D IV + D+ ++ E QQ+ I ++ L+ EL V+
Sbjct: 1244 RENRDLKDEIVRLNDS--ILQATEQRRRAEENALQQKACGSEIMQKKQHLEIELKQVMQQ 1301
Query: 4176 GSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFD 4235
SE D K+S++E NK + + +E + +Y++ L V +
Sbjct: 1302 RSE--------DNARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKVRN 1353
Query: 4236 WVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSE---AYQQQIE-MERLNHQAELLLKK 4291
D ++ + T++ K I +L K E Y+ QI+ + R N +K+
Sbjct: 1354 NYDEE--IISLKNQFETEINITKTTIHQLTMQKEEDTSGYRAQIDNLTRENRSLSEEIKR 1411
Query: 4292 VTEESDKHTVQDPLMELKLIWDSLEER------IINRQHKLEGALLALGQ--------FQ 4337
+ K+T+ L+ + + ++++ + R+ +LE L + Q ++
Sbjct: 1412 L-----KNTLTQTTENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQVTQMRTEESVRYK 1466
Query: 4338 HALDELLAWLTHTEGLLSEQKPV----GGDPKAIEIELAKHHVLQNDVL-AHQSTVEAVN 4392
+LD+ + + K + D K +E E A+ +Q D+ A+ S E +N
Sbjct: 1467 QSLDDAAKTIQDKNKEIERLKQLIDKETNDRKCLEDENARLQRVQYDLQKANSSATETIN 1526
Query: 4393 KAGNDLIESSAGEEASNLQNKLEVLNQ----------RWQNVLEKTEQRKQQLDGALRQA 4442
K +E + L+ E ++Q R+QN L++ + +KQ+++ L +
Sbjct: 1527 KL------KVQEQELTRLRIDYERVSQERTVKDQDITRFQNSLKELQLQKQKVEEELNRL 1580
Query: 4443 KGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQL----NVHMEVCAAFEAKEETYK 4498
K E D+ + + L G+ + KEQ N+ ++ A K+ +
Sbjct: 1581 KRTASE---------DSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQASIVKKRSED 1631
Query: 4499 SLMQ-------------KGQQMLARCPKSAET---------------------------N 4518
L Q + Q+ L R E +
Sbjct: 1632 DLRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAIED 1691
Query: 4519 IDQDINNLK---EKWESVETKLNERKTKLEEAL-NLAMEFHNSLQ-------DFINWLTQ 4567
+ +N K E+ +S+ L + LEE L NL +E+ + + D + +
Sbjct: 1692 KSRSLNESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSDKNATILE 1751
Query: 4568 AEQTLNVASRPSLILDTVLFQID-EHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVV 4626
L +++ +L L ++ + E + E+ ++Q +E K +Q VV
Sbjct: 1752 LRSQLQISNNRTLELQGLINDLQRERENLRQEIEKFQKQALEASNRIQESK--NQCTQVV 1809
Query: 4627 LIK-NLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSEL 4685
+ +LL+ + KV+++ R + L+D RAK EA +++ + LE ++
Sbjct: 1810 QERESLLVKI-----KVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQ------ 1858
Query: 4686 EIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSEL 4745
+I ND ++ KTQ ++ +E + + ++ +S +EK SL + +L + +
Sbjct: 1859 QIQNDLNQWKTQYSRKEEAIRKIESERE---------KSEREKNSLRSEIERLQAEIKRI 1909
Query: 4746 RDKWDTICGKSVERQNKLEEALL 4768
++ C + +E + ++ L
Sbjct: 1910 EER----CRRKLEDSTRETQSQL 1928
Score = 52.4 bits (124), Expect = 1e-05
Identities = 186/959 (19%), Positives = 361/959 (37%), Gaps = 164/959 (17%)
Query: 4007 KIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEM 4066
KI + +E E + P + I +I+E K+V D + + + LK +M
Sbjct: 674 KIRRQIEHCEGRMTLKNLPLADQGSSHHITVKINELKSVQNDSQAIAEVLNQLK----DM 729
Query: 4067 IARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIV 4126
+A G++K +Q+++ + ENI+ + + L C +L+
Sbjct: 730 LANFRGSEKYCY---LQNEVFGLFQKLENINGVTDGYLNSL-----------CTVRALLQ 775
Query: 4127 TIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINL---------GS 4177
I T+D ++ E + V + E R + ++ +L++ +L +
Sbjct: 776 AILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATMKTELQKA 835
Query: 4178 ELIAACGEPDKPIVK-------KSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGL 4230
+ I + P+ + + +L W ++K R+ LE+ ++ Y+D
Sbjct: 836 QQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNY 895
Query: 4231 QAVFDWVDIAGGKLASMSPIG-TDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLL 4289
QA W+ A + S+ + D TV + + E K SE ++ + E + AEL
Sbjct: 896 QAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELC- 954
Query: 4290 KKVTEESDKHTVQDPLMELKLIWDSLEERI---INRQ--HKLEGALLALGQFQHA-LDEL 4343
++++D ++L LE + I R G +L HA EL
Sbjct: 955 --------ANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIEL 1006
Query: 4344 LAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDV-LAHQSTVEAVNKAGNDLIESS 4402
L LSE D ++++ K VL+ ++ LA + E NK N ++ +
Sbjct: 1007 LTRSGDYYRFLSEMLKSLED---LKLKNTKIEVLEEELRLARDANSENCNK--NKFLDQN 1061
Query: 4403 AGE---EASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDT 4459
+ E S + KL L + + + KQ LD Q K + +I L + D
Sbjct: 1062 LQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDE 1121
Query: 4460 ERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNI 4519
+R V F+ ++ Y L QK +Q +
Sbjct: 1122 KRR--------------------RKSVEDRFDQQKNDYDQL-QKARQCEKENLGWQKLES 1160
Query: 4520 DQDINNLKEKWESVETKLNERKTKLEEALN-LAMEFHNSLQDFINWLTQAEQTLNVASRP 4578
++ I + + E + L E T+ E N LA ++ ++ N + E +N+
Sbjct: 1161 EKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYNEEMSNLRNKYETEINITK-- 1218
Query: 4579 SLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSR 4638
T + +I K ++ + R Q+ L + L K ++V +
Sbjct: 1219 -----TTIKEISMQK--EDDSKNLRNQLDRLSRENRDL-----KDEIVRLN--------- 1257
Query: 4639 WEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQL 4698
+ ++Q +R R A + A Q S++M +K E+E+ +
Sbjct: 1258 -DSILQATEQRRR----AEENALQQKACGSEIM------QKKQHLEIELKQVMQQRSEDN 1306
Query: 4699 AQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVE 4758
A+HK+ + A ++ D R E A + ++ LS++R+ +D
Sbjct: 1307 ARHKQSLEE--AAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKVRNNYD-------- 1356
Query: 4759 RQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKEL 4818
EE + QF + ++++ Q ED G + NL +++ +E+
Sbjct: 1357 -----EEIISLKNQFETEINITKTTIHQLTMQKEED--TSGYRAQIDNLTRENRSLSEEI 1409
Query: 4819 GKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQA 4878
+ +++ + R + +D K E+S R + +LE LRQ
Sbjct: 1410 KRLKNTLTQTTENLRRV----EEDIQQQKATGSEVSQR-----------KQQLEVELRQV 1454
Query: 4879 EEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEF--MKKLEEKRAELNK 4935
+ + E+++R+ L +DA +T+ D++KE +K+L +K K
Sbjct: 1455 TQMRT------------EESVRYKQSL---DDAAKTIQDKNKEIERLKQLIDKETNDRK 1498
Score = 50.1 bits (118), Expect = 6e-05
Identities = 195/1130 (17%), Positives = 439/1130 (38%), Gaps = 192/1130 (16%)
Query: 4225 QYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQ-IEELKQFKSEAYQQQIEMERLNH 4283
QY + + A+++ + I L S D+E ++ I +LK + E Y + I L++
Sbjct: 528 QYYEAILALWNQLYINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHY 587
Query: 4284 QAELLLKKVTE---ESDKHTVQDPLMELKLIWDSL------------------------- 4315
Q + + +E + DK +Q + + + +L
Sbjct: 588 QEFIRNSQGSEMFGDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQ 647
Query: 4316 ---EERII--NRQHKLEGALLALGQFQHALDELLAWLTHTEGLLS-EQKPVG--GDPKAI 4367
++I NR++ + + + L ++ + H EG ++ + P+ G I
Sbjct: 648 DVNHNKVIETNRENDKQETWMLM-----ELQKIRRQIEHCEGRMTLKNLPLADQGSSHHI 702
Query: 4368 EIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEK 4427
+++ + +QND Q+ E +N+ + L E+ LQN++ L Q+ +N+
Sbjct: 703 TVKINELKSVQND---SQAIAEVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGV 759
Query: 4428 TE-------------QRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPE 4474
T+ Q Q + L+ + E E + L E + K +
Sbjct: 760 TDGYLNSLCTVRALLQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKI----- 814
Query: 4475 TAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAET------NIDQDINNLKE 4528
K LN+ + A T K+ +QK QQ+ ++ + + + L +
Sbjct: 815 --KNDLNLKKSLLA-------TMKTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTD 865
Query: 4529 KWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTL-NVASRPSLILDTVLF 4587
+W+ ++ +++ R LE+ + + ++ Q F WL A++ ++ S +TV+
Sbjct: 866 RWQRIDKQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMR 925
Query: 4588 QIDEHKVFANEVNSHREQIIELDKTGT---------HLKYFSQKQDVVLIKNLLIS---V 4635
++E K +E++ R++ E+ K L+ S + + N+ I +
Sbjct: 926 FLNEQKNLHSEISGKRDKSEEVQKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMI 985
Query: 4636 QSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESE------KSLDSELEIAN 4689
QS ++Q + + R+ ++ S++++ LE+ + + L+ EL +A
Sbjct: 986 QSPSGVILQEAADVHARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLAR 1045
Query: 4690 DPD------------KIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKT-----SLA 4732
D + ++ A+ +F+ L + + G+S K+ +
Sbjct: 1046 DANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIK 1105
Query: 4733 DDNLKLDDMLSELRDKWDTICGKSVERQ--------NKLEEALL-----FSGQFTDALQA 4779
+ N K+ + E+ D + KSVE + ++L++A Q ++ +A
Sbjct: 1106 ELNEKITRLTYEIED--EKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKA 1163
Query: 4780 LIDWLYRVE---PQLAEDQPVHGDIDLVMNLIDNHKAFQKEL----GKRTSSVQALKRSA 4832
+ + Y +E L E+ + + + + NH + +E+ K + + K +
Sbjct: 1164 IKEKEYEIERLRVLLQEEGTRKREYENELAKVRNH--YNEEMSNLRNKYETEINITKTTI 1221
Query: 4833 RELIEGSRDDSSWVKVQMQELSTR-----------WETVCALSISKQTRLEAALRQ---- 4877
+E+ DDS ++ Q+ LS +++ + ++ E AL+Q
Sbjct: 1222 KEISMQKEDDSKNLRNQLDRLSRENRDLKDEIVRLNDSILQATEQRRRAEENALQQKACG 1281
Query: 4878 AEEFHSVVHALLE----WLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAEL 4933
+E H +E +E R L E+A +T+ D++KE + E + E
Sbjct: 1282 SEIMQKKQHLEIELKQVMQQRSEDNARHKQSL---EEAAKTIQDKNKEIERLKAEFQEEA 1338
Query: 4934 NKATTMGDTVLAI--CHPDSITTIKHW----ITIIRARFEEVLAWAKQHQQRLASALAGL 4987
+ + + + + + I ++K+ I I + ++ ++ + + L
Sbjct: 1339 KRRWEYENELSKVRNNYDEEIISLKNQFETEINITKTTIHQLTMQKEEDTSGYRAQIDNL 1398
Query: 4988 IAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAE---------------HQT 5032
+ L + L+ T T+ + V ++I++ KA +E Q
Sbjct: 1399 TRENRSLSEEIKRLKNTLTQTTENLRRV-EEDIQQQKATGSEVSQRKQQLEVELRQVTQM 1457
Query: 5033 FMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQI 5092
EE R + +D KT + + + L+ ++DK RK + Q +
Sbjct: 1458 RTEESVRYKQSLDDAAKTIQDKNKEIERLKQ---LIDKETNDRKCLEDENARLQRVQYDL 1514
Query: 5093 ETKN----PRVNLLVSKWQQVWLLALERRRKLNDALDRLEELREFANF--DFDIWRKKYM 5146
+ N +N L + Q++ L ++ R + + +++ F N + + ++K
Sbjct: 1515 QKANSSATETINKLKVQEQELTRLRIDYERVSQERTVKDQDITRFQNSLKELQLQKQKVE 1574
Query: 5147 RWMNH-KKSRVMDFFRRIDKDQDGKITRQEFIDGILSSKFPTSRLEMSAV 5195
+N K++ D +R +++ + R+ + + T +LE +++
Sbjct: 1575 EELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQASI 1624
Score = 43.1 bits (100), Expect = 0.008
Identities = 70/325 (21%), Positives = 127/325 (39%), Gaps = 37/325 (11%)
Query: 4790 QLAEDQPVHGDIDL--VMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVK 4847
Q AE V +DL V I++H+ +G + +K RE K
Sbjct: 198 QRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKADLRE------------K 245
Query: 4848 VQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPD 4907
+ +L +E + S + L RQ + + W+ + E+ +L D
Sbjct: 246 SAIYQLEEEYENLLKASFERMDHL----RQLQNIIQATSREIMWINDCEE----EELLYD 297
Query: 4908 DEDALRTLIDQHKEF---MKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRA 4964
D + + + F M +LE K ELNK D ++ HP S I+ ++ ++
Sbjct: 298 WSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPAS-DKIEAYMDTLQT 356
Query: 4965 RFEEVLAWAKQHQQRLA--SALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQE-IE 5021
++ +L K L +A + + EA L LQ + DK + Q +E
Sbjct: 357 QWSWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLE 416
Query: 5022 EVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPAS 5081
++K L E + +E + Q V+K K + + +P +S+ P++ + K+
Sbjct: 417 QIKELEKEREKILEYKRQVQNLVNKSKKIVQLKPRNP-DYRSNKPIILRALCDYKQ--DQ 473
Query: 5082 SLYPSGSQTQIETKNPRVNLLVSKW 5106
+ G + ++ N R SKW
Sbjct: 474 KIVHKGDECILKDNNER-----SKW 493
Score = 35.8 bits (81), Expect = 1.2
Identities = 16/28 (57%), Positives = 22/28 (78%)
Query: 5450 ADSKKTPSRPGSRAGSKAGSRASSRRGS 5477
A ++ SR GSR+GS++GSR+ SRRGS
Sbjct: 2822 APGSRSGSRSGSRSGSRSGSRSGSRRGS 2849
Score = 35.4 bits (80), Expect = 1.6
Identities = 16/27 (59%), Positives = 20/27 (74%)
Query: 5457 SRPGSRAGSKAGSRASSRRGSDASDFD 5483
SR GSR+GS++GSR+ SR GS FD
Sbjct: 2825 SRSGSRSGSRSGSRSGSRSGSRRGSFD 2851
Score = 33.1 bits (74), Expect = 7.9
Identities = 20/44 (45%), Positives = 27/44 (61%), Gaps = 1/44 (2%)
Query: 5435 SGLITTAAARVRTQFADSK-KTPSRPGSRAGSKAGSRASSRRGS 5477
+GL AA V ++ S S PGSR+GS++GSR+ SR GS
Sbjct: 2798 TGLRLLEAASVSSKGLPSPYNMSSAPGSRSGSRSGSRSGSRSGS 2841
>gi|58530842 desmoplakin isoform II [Homo sapiens]
Length = 2272
Score = 577 bits (1488), Expect = e-164
Identities = 350/1260 (27%), Positives = 651/1260 (51%), Gaps = 131/1260 (10%)
Query: 641 EEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKI 700
+E + L W+ + + ++D WG DL SVE H+ +H+ +H +I ++ L + K
Sbjct: 181 DEFTKHVTSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKA 240
Query: 701 SEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE 760
+ +A +++LE +Y LL S + HL L N + + E++W+N+ EE
Sbjct: 241 DLREKSA---------IYQLEEEYENLLKASFERMDHLRQLQNIIQATSREIMWINDCEE 291
Query: 761 EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR 820
EE+ YDWS++NTNIA+K++ + M +L+ KE+ + +++ ++QL+L HPA IEAY
Sbjct: 292 EELLYDWSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYM 351
Query: 821 AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSI 880
+QTQWSWILQ+ +C++ H+KEN AYF+FF +A+ YL+ L+D+I++KY CD++ +
Sbjct: 352 DTLQTQWSWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPL 411
Query: 881 HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ 940
L + ++E +E+E++L+YK + NL+ K+K I+QLKPRN D I ++A+CDY+Q
Sbjct: 412 QHLLEQIKELEKEREKILEYKRQVQNLVNKSKKIVQLKPRNPDYRSNKPIILRALCDYKQ 471
Query: 941 IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ 1000
+ ++K DEC+L +N+ R+KW V P G + +VPSV +PPPN AVDL+ +IEQ Y+
Sbjct: 472 DQKIVHKGDECILKDNNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYYE 531
Query: 1001 NVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFL 1060
+L LW++ +INMKS+VSWHY + +I++IRA +A +KTM ++ + +++L+ +++F+
Sbjct: 532 AILALWNQLYINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFI 591
Query: 1061 EDSQESQVFSGSDITQLEKEVNVCKQYYQELL---------------------------- 1092
+SQ S++F D +++ + +++YQ L+
Sbjct: 592 RNSQGSEMFGDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQDVNH 651
Query: 1093 -KSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEK 1151
K E + + + E++ IR ++E+CE R+ + ++ H +I E +
Sbjct: 652 NKVIETNRENDKQETWMLMELQKIRRQIEHCEGRMTLKNLPLADQGSSHHITVKINELKS 711
Query: 1152 LKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKL 1211
++ + + + + + N+ ++ + S L++E+ + Q + + ++ Y++ L
Sbjct: 712 VQNDSQAIAE----VLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSL 767
Query: 1212 KTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHA 1271
TV +L+ E ++K+YE +L EEE V D + +E LK+ +++++ K+ +
Sbjct: 768 CTVRALLQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLAT 827
Query: 1272 LEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKS 1331
++ ELQKA+ I + + Y DLD EK QL +RWQ + QID RL DLE K
Sbjct: 828 MKTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQ 887
Query: 1332 LKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDEC 1391
L+ YRD Y W+ + Q ++ + +S T+ LN+QK L SEI K+ K +E
Sbjct: 888 LRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEV 947
Query: 1392 QKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALV 1451
QK AE + ++KDYELQ +Y + +++ P+KR +QS + +I+QE D+ RY L+
Sbjct: 948 QKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELL 1007
Query: 1452 TLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPF 1511
T Y +F + LK L E+ L+ K E +E + L+ A A
Sbjct: 1008 TRSGDYYRFLSEMLKSL--EDLKLKNTKIEVLE-------------EELRLARDANSENC 1052
Query: 1512 SKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSE 1571
+K K + + + + S+ F AK +E + + E K+ +++ + + +
Sbjct: 1053 NKNKFLDQNLQKYQAECSQ-------FKAKLAS--LEELKRQAELDGKSAKQNLDKCYGQ 1103
Query: 1572 SLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTV 1631
+K+L E T ++E++ K + + + D Q +N Q+A +
Sbjct: 1104 -IKELNEKITRLTYEIEDE---------KRRRKSVEDRFDQQKNDYDQLQKARQCEKENL 1153
Query: 1632 ELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIE--QKLNEAKI 1689
+K +S++ +K+ + ++ L+E G + + + L + ++ E+K
Sbjct: 1154 GWQKLESEKAIKEKEYE---------IERLRVLLQEEGTRKREYENELAKASNRIQESKN 1204
Query: 1690 KCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSER 1749
+C Q+ ++E + +K LE+ K +++ L D L N K +
Sbjct: 1205 QCTQV------------------VQERESLLVKIKVLEQDKARLQRLEDEL-NRAKSTLE 1245
Query: 1750 AGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKA 1809
A T+ KQ +E E+ ++ +L Q T + +K+++
Sbjct: 1246 AETRVKQRLE---------------CEKQQIQNDL------NQWKTQYSRKEEAIRKIES 1284
Query: 1810 QHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKM 1869
+ EK + ++ + Q +++ + + KL+ + +E + ET + ++++
Sbjct: 1285 EREKSEREKNSLRSEIERLQAEIKR----IEERCRRKLEDSTRETQSQLETERSRYQREI 1340
Score = 63.9 bits (154), Expect = 4e-09
Identities = 124/642 (19%), Positives = 249/642 (38%), Gaps = 89/642 (13%)
Query: 3305 QSAAKSTSTQGLEHDLD---------DVNARWKTLNKKVAQRAAQLQEALLHCGRFQDAL 3355
Q TS Q +DLD + RW+ ++K++ R L++ + ++D
Sbjct: 836 QQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNY 895
Query: 3356 ESLLSWMVDTEELVAN-QKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIA 3414
++ W+ D + + + + V + EQK L + ++ E +++ E A
Sbjct: 896 QAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELCA 955
Query: 3415 TTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQ-------FHETLEPL 3467
+ + + QL+ S E LLN R V+ Q+ + E L
Sbjct: 956 NSIKDYE-----LQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLTRS 1010
Query: 3468 NEWLTTIEKRLVNCEPI---GTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQ---- 3520
++ + + L + E + T+ LEE++ + + N NK L Q + Q
Sbjct: 1011 GDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECS 1070
Query: 3521 -------SLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDE 3573
SL+ L + + D +K + + Y +I+E + + L + + + K +
Sbjct: 1071 QFKAKLASLEELKRQAELDGKSAKQNLDKC-YGQIKELNEKITRLTYE-IEDEKRRRKSV 1128
Query: 3574 VELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSE------------LRVLQEDILLRKQNV 3621
+ + +D+L K + G K +SE LRVL ++ RK+
Sbjct: 1129 EDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREY 1188
Query: 3622 DQALLNGLELLKQTTGDEVLIIQDK---------LEAIKARYKDITKLSTDVAKTLEQAL 3672
+ L ++++ ++Q++ LE KAR + + TLE
Sbjct: 1189 ENELAKASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAET 1248
Query: 3673 QLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDS 3732
++ +RL ++ ++ +L ++TQ + EEA + +E + KN+ L S
Sbjct: 1249 RVKQRLECEKQQ-------IQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNS---LRS 1298
Query: 3733 LNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAAD 3792
E A ++ + R R LE E + + ++ EID R +
Sbjct: 1299 EIERLQAEIKRIEERCRRKLEDSTRETQSQ---LETERSRYQREIDKLRQRPYGSHRETQ 1355
Query: 3793 AELSWITETEKKLMSLGDIRLEQDQTSAQLQ----VQKTFTMEILRHKDIIDDLVK---- 3844
E W +T K + L + T+ QL + KT ++L+ K ++++
Sbjct: 1356 TECEWTVDTSKLVFD----GLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVASEIQP 1411
Query: 3845 ----SGHKIMTACSEEEKQSM-KKKLDKVLKNYDTICQINSE 3881
+G + S +EK S+ + K K++ T+ + ++
Sbjct: 1412 FLRGAGSIAGASASPKEKYSLVEAKRKKLISPESTVMLLEAQ 1453
Score = 53.5 bits (127), Expect = 6e-06
Identities = 145/820 (17%), Positives = 331/820 (40%), Gaps = 132/820 (16%)
Query: 4225 QYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQ-IEELKQFKSEAYQQQIEMERLNH 4283
QY + + A+++ + I L S D+E ++ I +LK + E Y + I L++
Sbjct: 528 QYYEAILALWNQLYINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHY 587
Query: 4284 QAELLLKKVTE---ESDKHTVQDPLMELKLIWDSL------------------------- 4315
Q + + +E + DK +Q + + + +L
Sbjct: 588 QEFIRNSQGSEMFGDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQ 647
Query: 4316 ---EERII--NRQHKLEGALLALGQFQHALDELLAWLTHTEGLLS-EQKPVG--GDPKAI 4367
++I NR++ + + + L ++ + H EG ++ + P+ G I
Sbjct: 648 DVNHNKVIETNRENDKQETWMLM-----ELQKIRRQIEHCEGRMTLKNLPLADQGSSHHI 702
Query: 4368 EIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEK 4427
+++ + +QND Q+ E +N+ + L E+ LQN++ L Q+ +N+
Sbjct: 703 TVKINELKSVQND---SQAIAEVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGV 759
Query: 4428 TE-------------QRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPE 4474
T+ Q Q + L+ + E E + L E + K +
Sbjct: 760 TDGYLNSLCTVRALLQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKI----- 814
Query: 4475 TAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAET------NIDQDINNLKE 4528
K LN+ + A T K+ +QK QQ+ ++ + + + L +
Sbjct: 815 --KNDLNLKKSLLA-------TMKTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTD 865
Query: 4529 KWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTL-NVASRPSLILDTVLF 4587
+W+ ++ +++ R LE+ + + ++ Q F WL A++ ++ S +TV+
Sbjct: 866 RWQRIDKQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMR 925
Query: 4588 QIDEHKVFANEVNSHREQIIELDKTGT---------HLKYFSQKQDVVLIKNLLIS---V 4635
++E K +E++ R++ E+ K L+ S + + N+ I +
Sbjct: 926 FLNEQKNLHSEISGKRDKSEEVQKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMI 985
Query: 4636 QSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESE------KSLDSELEIAN 4689
QS ++Q + + R+ ++ S++++ LE+ + + L+ EL +A
Sbjct: 986 QSPSGVILQEAADVHARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLAR 1045
Query: 4690 DPD------------KIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLK 4737
D + ++ A+ +F+ L + + G+S K+ +K
Sbjct: 1046 DANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIK 1105
Query: 4738 -LDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQA---LIDWLYRVEPQLAE 4793
L++ ++ L + + + +++ ++ Q A Q + W ++E + A
Sbjct: 1106 ELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGW-QKLESEKAI 1164
Query: 4794 DQPVHGDIDLVMNLIDNH----KAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQ 4849
+ + +I+ + L+ + ++ EL K ++ +Q K ++++ +KV
Sbjct: 1165 KEKEY-EIERLRVLLQEEGTRKREYENELAKASNRIQESKNQCTQVVQERESLLVKIKVL 1223
Query: 4850 MQELSTRWETVCALSISKQTRLEAALRQAE----EFHSVVHALLEW---LAEAEQTLR-- 4900
Q+ + L+ +K T LEA R + E + + L +W + E+ +R
Sbjct: 1224 EQDKARLQRLEDELNRAKST-LEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKI 1282
Query: 4901 --FHGVLPDDEDALRTLIDQHKEFMKKLEEK-RAELNKAT 4937
++++LR+ I++ + +K++EE+ R +L +T
Sbjct: 1283 ESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLEDST 1322
Score = 52.0 bits (123), Expect = 2e-05
Identities = 132/763 (17%), Positives = 306/763 (40%), Gaps = 86/763 (11%)
Query: 3619 QNVDQALLNGLELLKQTTG-----DEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQ 3673
QN QA+ L LK ++ +Q+++ + + ++I ++ +L
Sbjct: 713 QNDSQAIAEVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSLCTVRA 772
Query: 3674 LARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSL 3733
L + + T + L + E L ET L ++ + K++K + K+LL ++
Sbjct: 773 LLQAILQTEDMLKVY----EARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATM 828
Query: 3734 N-------EVSSALLELVPWRARE--GLEKMVAEDNERYRLVSDTITQKVEEIDAAILRS 3784
++ S + P + + V + +R++ + I ++ +++ I +
Sbjct: 829 KTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQL 888
Query: 3785 QQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQ-LQVQKTFTMEILRHKDIIDDLV 3843
+ + A W+ + +++ SL ++ T + L QK EI +D +++
Sbjct: 889 RNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQ 948
Query: 3844 KSGHKIMTACSEEEKQ--SMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYE 3901
K + + E Q S L+ +L I S + L+ A + ++ E
Sbjct: 949 KIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLT 1008
Query: 3902 ELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLEL 3961
+ ++ L L+ + +EE R R+ +E+ NK Q L+
Sbjct: 1009 RSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENC----NKNKFLDQNLQK 1064
Query: 3962 SPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVER 4021
E + K + + L Q + D K LD+ Q + ++KI ++ +E E+
Sbjct: 1065 YQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIED--EK 1122
Query: 4022 LRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKA 4081
R+ + ++++ + KN D ++LQ + K+ + G K S KA
Sbjct: 1123 RRR--------KSVEDRFDQQKN---DYDQLQKARQCEKE--------NLGWQKLESEKA 1163
Query: 4082 VQDKLDQMVFIWENIHTLVEEREAKLLDV-MELAEKFWCDHMSLIVTIKDTQDFIRDLED 4140
+++K ++ E + L++E + + ELA+ + + +++ E
Sbjct: 1164 IKEKEYEI----ERLRVLLQEEGTRKREYENELAKA----SNRIQESKNQCTQVVQERES 1215
Query: 4141 PGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNS 4200
+ V++Q + + + +E++ + L+ + L E +K ++ +++
Sbjct: 1216 LLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRL-----ECEKQQIQNDLNQ--- 1267
Query: 4201 AWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQ 4260
W + ++ I K+E + + + ++ L+ + + + +++ ++++
Sbjct: 1268 -WKTQYSRKEEAIRKIESEREKSEREKNSLR-------------SEIERLQAEIKRIEER 1313
Query: 4261 IEELKQFKSEAYQQQIEMERLNHQAEL-LLKKVTEESDKHTVQD---PLMELKLIWDSLE 4316
+ + Q Q+E ER +Q E+ L++ S + T + + KL++D L
Sbjct: 1314 CRRKLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLR 1373
Query: 4317 ERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKP 4359
+++ Q E L+ + LD+LL E + SE +P
Sbjct: 1374 KKVTAMQ-LYECQLID----KTTLDKLLKGKKSVEEVASEIQP 1411
Score = 50.1 bits (118), Expect = 6e-05
Identities = 99/551 (17%), Positives = 224/551 (40%), Gaps = 68/551 (12%)
Query: 2563 LNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQV 2622
L Q + + L+ LT+ +TV L + + + + L++ ++L T + ++
Sbjct: 773 LLQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATMKTEL 832
Query: 2623 QILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRC 2682
Q Q + QY P D L G E++ +T +W + Q+ R
Sbjct: 833 QKAQQIHSQTSQQY-------------PLYDLDL-GKFGEKVTQLTDRWQRIDKQIDFRL 878
Query: 2683 DWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVST-HPDAMNQQLETAQKMKQEIQ 2741
+++ I + Y+ ++ L D + S ++ + + + L + + EI
Sbjct: 879 WDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEIS 938
Query: 2742 QEKKQIKVAQALCEDLSALVKEEYLK-AELSRQLEGILK-----------SFKDVEQKAE 2789
++ + + Q + E + +K+ L+ A + LE +L S +++ A+
Sbjct: 939 GKRDKSEEVQKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAAD 998
Query: 2790 NHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKT 2849
H ++++ S ++ +S ++ D K + + K++VLE ++ +D +
Sbjct: 999 VHARYIELLTRSGDYYRFLSEMLKSLEDLKLK--------NTKIEVLEEELRLARDANSE 1050
Query: 2850 LTAQSHMYEKTI----AEGENLLLKTQGSEKAALQLQLN--TIKTNWDTFNKQVKERENK 2903
++ ++ + AE K E+ Q +L+ + K N D Q+KE K
Sbjct: 1051 NCNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEK 1110
Query: 2904 LKE---SLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQ 2960
+ +E + ++ VE + + L++ + C G + K++ KE +
Sbjct: 1111 ITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAI-KEKEY 1169
Query: 2961 HFGMVELL------------NNTANSLLSVCEIDKEV--VTDENKSLIQKVDMVTEQLHS 3006
+ +L N A + + E + V E +SL+ K+ V EQ +
Sbjct: 1170 EIERLRVLLQEEGTRKREYENELAKASNRIQESKNQCTQVVQERESLLVKIK-VLEQDKA 1228
Query: 3007 KKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQ 3066
+ LE+ + K E K++L+C K+Q+ Q N++ T ++++++
Sbjct: 1229 RLQRLEDELNRAKSTLEAETRVKQRLECEKQQI--------QNDLNQWKTQYSRKEEAIR 1280
Query: 3067 ALKHQVDLAKR 3077
++ + + ++R
Sbjct: 1281 KIESEREKSER 1291
Score = 48.5 bits (114), Expect = 2e-04
Identities = 140/703 (19%), Positives = 270/703 (38%), Gaps = 92/703 (13%)
Query: 4007 KIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEM 4066
KI + +E E + P + I +I+E K+V D + + + LK +M
Sbjct: 674 KIRRQIEHCEGRMTLKNLPLADQGSSHHITVKINELKSVQNDSQAIAEVLNQLK----DM 729
Query: 4067 IARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIV 4126
+A G++K +Q+++ + ENI+ + + L C +L+
Sbjct: 730 LANFRGSEKYCY---LQNEVFGLFQKLENINGVTDGYLNSL-----------CTVRALLQ 775
Query: 4127 TIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINL---------GS 4177
I T+D ++ E + V + E R + ++ +L++ +L +
Sbjct: 776 AILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATMKTELQKA 835
Query: 4178 ELIAACGEPDKPIVK-------KSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGL 4230
+ I + P+ + + +L W ++K R+ LE+ ++ Y+D
Sbjct: 836 QQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNY 895
Query: 4231 QAVFDWVDIAGGKLASMSPIG-TDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLL 4289
QA W+ A + S+ + D TV + + E K SE ++ + E + AEL
Sbjct: 896 QAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELC- 954
Query: 4290 KKVTEESDKHTVQDPLMELKLIWDSLEERI---INRQ--HKLEGALLALGQFQHA-LDEL 4343
++++D ++L LE + I R G +L HA EL
Sbjct: 955 --------ANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIEL 1006
Query: 4344 LAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDV-LAHQSTVEAVNKAGNDLIESS 4402
L LSE D ++++ K VL+ ++ LA + E NK N ++ +
Sbjct: 1007 LTRSGDYYRFLSEMLKSLED---LKLKNTKIEVLEEELRLARDANSENCNK--NKFLDQN 1061
Query: 4403 AGE---EASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDT 4459
+ E S + KL L + + + KQ LD Q K + +I L + D
Sbjct: 1062 LQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDE 1121
Query: 4460 ERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNI 4519
+R V F+ ++ Y L QK +Q +
Sbjct: 1122 KRR--------------------RKSVEDRFDQQKNDYDQL-QKARQCEKENLGWQKLES 1160
Query: 4520 DQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPS 4579
++ I + + E + L E T+ E N + N +Q+ N TQ V R S
Sbjct: 1161 EKAIKEKEYEIERLRVLLQEEGTRKREYENELAKASNRIQESKNQCTQV-----VQERES 1215
Query: 4580 LILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRW 4639
L++ + + D+ ++ E +R + +T + +KQ I+N L ++W
Sbjct: 1216 LLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQ---IQNDL----NQW 1268
Query: 4640 EKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLD 4682
+ R E R ++ R+++++ + +E L+ K ++
Sbjct: 1269 KTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIE 1311
Score = 43.1 bits (100), Expect = 0.008
Identities = 70/325 (21%), Positives = 127/325 (39%), Gaps = 37/325 (11%)
Query: 4790 QLAEDQPVHGDIDL--VMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVK 4847
Q AE V +DL V I++H+ +G + +K RE K
Sbjct: 198 QRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKADLRE------------K 245
Query: 4848 VQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPD 4907
+ +L +E + S + L RQ + + W+ + E+ +L D
Sbjct: 246 SAIYQLEEEYENLLKASFERMDHL----RQLQNIIQATSREIMWINDCEE----EELLYD 297
Query: 4908 DEDALRTLIDQHKEF---MKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRA 4964
D + + + F M +LE K ELNK D ++ HP S I+ ++ ++
Sbjct: 298 WSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPAS-DKIEAYMDTLQT 356
Query: 4965 RFEEVLAWAKQHQQRLA--SALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQE-IE 5021
++ +L K L +A + + EA L LQ + DK + Q +E
Sbjct: 357 QWSWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLE 416
Query: 5022 EVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPAS 5081
++K L E + +E + Q V+K K + + +P +S+ P++ + K+
Sbjct: 417 QIKELEKEREKILEYKRQVQNLVNKSKKIVQLKPRNP-DYRSNKPIILRALCDYKQ--DQ 473
Query: 5082 SLYPSGSQTQIETKNPRVNLLVSKW 5106
+ G + ++ N R SKW
Sbjct: 474 KIVHKGDECILKDNNER-----SKW 493
Score = 42.4 bits (98), Expect = 0.013
Identities = 102/546 (18%), Positives = 223/546 (40%), Gaps = 84/546 (15%)
Query: 2505 VKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELN 2564
+K + KS A +K + K Q++ + ++ + + ++ + +T++ +WQ ++
Sbjct: 814 IKNDLNLKKSLLATMKTELQKAQQIHSQTSQ--QYPLYDLDLGKFGEKVTQLTDRWQRID 871
Query: 2565 QLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSI-DPN----MLNTQR 2619
+ R LE+ L ++ +WL + + L + D N LN Q+
Sbjct: 872 KQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQK 931
Query: 2620 -------------QQVQILLQEFATRKPQYE----QLTAAGQGILSRPGEDPSLR---GI 2659
++VQ + + A YE T+ + +L+ P + ++ G+
Sbjct: 932 NLHSEISGKRDKSEEVQKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGV 991
Query: 2660 VKEQLAAVTQKWDSLTGQ-------LSDRCDWIDQAIVKSTQYQSL---LRSLSDKLSDL 2709
+ ++ A V ++ L + LS+ ++ +K+T+ + L LR D S+
Sbjct: 992 ILQEAADVHARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSEN 1051
Query: 2710 DNK---LSSSL-AVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEY 2765
NK L +L +L + +++K++ + + K K C + E+
Sbjct: 1052 CNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKI 1111
Query: 2766 LKAELSRQLEGILKSFKDVEQK---AENHVQHLQSACASSHQFQQMSRDFQAW--LDTKK 2820
+ L+ ++E + K VE + +N LQ A +Q ++ W L+++K
Sbjct: 1112 TR--LTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKA-------RQCEKENLGWQKLESEK 1162
Query: 2821 EEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKT-------IAEGENLLLKTQG 2873
+ K + I +L+ +++ L S+ +++ + E E+LL+K +
Sbjct: 1163 AIKEKEYEIERLRVLLQEEGTRKREYENELAKASNRIQESKNQCTQVVQERESLLVKIKV 1222
Query: 2874 SEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLE 2933
E+ +LQ ++++ N+ K +LE + K+++E I QN+L
Sbjct: 1223 LEQDKARLQ-------------RLEDELNRAKSTLEAETRVKQRLECEKQQI---QNDLN 1266
Query: 2934 EIKFCLDPAEGENSIAKLKS----LQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDE 2989
+ K + E +I K++S ++E + +E L + C E T E
Sbjct: 1267 QWK--TQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLEDSTRE 1324
Query: 2990 NKSLIQ 2995
+S ++
Sbjct: 1325 TQSQLE 1330
Score = 41.2 bits (95), Expect = 0.029
Identities = 58/293 (19%), Positives = 126/293 (43%), Gaps = 40/293 (13%)
Query: 2363 KSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNL----------ISAVTTPAKA-IAAVKS 2411
KSLED K K + E++ ++ CN A + KA +A+++
Sbjct: 1022 KSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEE 1081
Query: 2412 --GGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLK---DKIAELNTKL 2466
A L+G+ N ++ + + + + +T +++ ED K D+ +
Sbjct: 1082 LKRQAELDGKSAKQNLDKCYGQ--IKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDY 1139
Query: 2467 SKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKV 2526
+LQKA++ + W + ++ A K ++ ++ + + + +E EL + N++
Sbjct: 1140 DQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKASNRI 1199
Query: 2527 QELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQT 2586
QE K++ T++++E + +L +I Q+ +L Q+LE+ N
Sbjct: 1200 QESKNQCTQVVQER---------ESLLVKIKVLEQDKARL-----QRLEDELNRAKSTLE 1245
Query: 2587 VEAQLKQWL-VEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQ 2638
E ++KQ L EK+ + D N TQ + + +++ + + + E+
Sbjct: 1246 AETRVKQRLECEKQ-------QIQNDLNQWKTQYSRKEEAIRKIESEREKSER 1291
Score = 35.8 bits (81), Expect = 1.2
Identities = 16/28 (57%), Positives = 22/28 (78%)
Query: 5450 ADSKKTPSRPGSRAGSKAGSRASSRRGS 5477
A ++ SR GSR+GS++GSR+ SRRGS
Sbjct: 2223 APGSRSGSRSGSRSGSRSGSRSGSRRGS 2250
Score = 35.4 bits (80), Expect = 1.6
Identities = 16/27 (59%), Positives = 20/27 (74%)
Query: 5457 SRPGSRAGSKAGSRASSRRGSDASDFD 5483
SR GSR+GS++GSR+ SR GS FD
Sbjct: 2226 SRSGSRSGSRSGSRSGSRSGSRRGSFD 2252
Score = 33.1 bits (74), Expect = 7.9
Identities = 20/44 (45%), Positives = 27/44 (61%), Gaps = 1/44 (2%)
Query: 5435 SGLITTAAARVRTQFADSK-KTPSRPGSRAGSKAGSRASSRRGS 5477
+GL AA V ++ S S PGSR+GS++GSR+ SR GS
Sbjct: 2199 TGLRLLEAASVSSKGLPSPYNMSSAPGSRSGSRSGSRSGSRSGS 2242
>gi|154277116 spectrin repeat containing, nuclear envelope 1 isoform 1
[Homo sapiens]
Length = 8797
Score = 372 bits (955), Expect = e-102
Identities = 721/4028 (17%), Positives = 1590/4028 (39%), Gaps = 442/4028 (10%)
Query: 1325 LEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQL---NQQKMLVSEI 1381
L G ++Y + L++ I + Q + ++ + A QL +QQK I
Sbjct: 1228 LSNFGDCVQYKEIVKNSLEELISGSKEVQEQAEKILDTENLFEAQQLLLHHQQK--TKRI 1285
Query: 1382 EMKQSKMDECQKYAEQYSATVKDYELQTMT-YRAMVDSQQKSPVKRRRMQSSADLIIQEF 1440
K+ + + A+Q + D + + + +D ++S R R + + ++++
Sbjct: 1286 SAKKRDVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERS---RERQERRIQVTLRKW 1342
Query: 1441 MDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNIS--- 1497
T +V +Y+ G S +R SLE E +E+ KE K +I+
Sbjct: 1343 ERFETNKETVV----RYLFQTGSSHERFLSFS-SLESLSSE-LEQTKEFSKRTESIAVQA 1396
Query: 1498 -KTLKDAEKAGKPPFSKQ------KISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEE 1550
+K+A + P +KQ K E++ ++ L E ++T+++ K D
Sbjct: 1397 ENLVKEASEIPLGPQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKW-----DHF 1451
Query: 1551 RNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLL 1610
+ E + E + L L+ S ++ D+++ + + QE + KL I L
Sbjct: 1452 GSNFETLSVWITEK-----EKELNALETSSSAMDMQISQ--IKVTIQEIESKLSSIVGLE 1504
Query: 1611 TQTEN--RLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQA-LAEVVKNTENFLKE 1667
+ ++ + + E+ I ++++Y + E + ++G+ L++ K EN K
Sbjct: 1505 EEAQSFAQFVTTGESARIKAKLTQIRRYGEELREHAQCLEGTILGHLSQQQKFEENLRKI 1564
Query: 1668 NGEKLSQEDKALIEQKLNEAKI---KCEQLNLKAEQSKKELDKVVTT------------- 1711
EDK + K+ + K Q ++ Q+ + L +T
Sbjct: 1565 QQSVSEFEDKLAVPIKICSSATETYKVLQEHMDLCQALESLSSAITAFSASARKVVNRDS 1624
Query: 1712 ------AIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHF 1765
A++++ E + +++ +E +T +ENLL ++K+ + T
Sbjct: 1625 CVQEAAALQQQYEDI--LRRAKERQTALENLLAHWQRLEKE-----------LSSFLTWL 1671
Query: 1766 QEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIAT 1825
+ G+ K++ E D + + + + Q ++A +++SQ A+
Sbjct: 1672 ERGEAKASSPEMD--------------ISADRVKVEGELQLIQALQNEVVSQ------AS 1711
Query: 1826 QSAQVLLEKQGQY--LSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFD 1883
+++L K+ + S ++ + ++ ++++L + K++ S+ E ++FD
Sbjct: 1712 FYSKLLQLKESLFSVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFD 1771
Query: 1884 ADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNR 1943
F W++ EL+ I L R K + +V S KG+L+ ++ G+
Sbjct: 1772 ELLLSFSVWIKLFLSELQT--TSEISIMDHQVALTRHKDHAAEVESKKGELQ--SLQGHL 1827
Query: 1944 VLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNN---LKDLVDKY 2000
K+ + ++ A D F+ V+ L L +
Sbjct: 1828 A-------------KLGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLAEFL 1874
Query: 2001 QHYEDASCGLLAGL-QACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEK 2059
Q + S G+L L Q EAT S + +E ++ K+L L+ KAL+ S V+++
Sbjct: 1875 QSHASLS-GILRQLRQTVEATNSMNKNESDLIE-KDLNDALQNAKALE----SAAVSLDG 1928
Query: 2060 LKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDG 2119
+ A+ L S + + T D + G E + + + + + QD
Sbjct: 1929 ILSKAQYHLKIGSS--EQRTSCRATADQLCGEVERIQNLLGTKQSEADALAVLKKAFQDQ 1986
Query: 2120 LDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFM 2179
+E+L + ++E ++ ALQ + LE ++ + + + +K K+
Sbjct: 1987 KEELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHELCWLKDKAKQIA 2046
Query: 2180 ETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETK 2239
+ D + A + ++ L + + E + L + ++NL + LE
Sbjct: 2047 QK-DVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVSKVLENA 2105
Query: 2240 TQAL-TEVDVPGKDVTELS-------------QYMQESTSEFLEHKKHLEVLHSLLKEIS 2285
+ + T + KD +L Y Q+ F KHL S LK+I
Sbjct: 2106 SSVIVTRTTI--KDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLL---SELKKIH 2160
Query: 2286 SHG---LPSDKALVLEKTNNLSKKFKEMEDTIKEKK---EAVTSCQEQLDAFQVLVKSLK 2339
S + +D ++K ++S+K +E D ++ + V S +++++ +
Sbjct: 2161 SSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWS------N 2214
Query: 2340 SWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQ-KVNNSGISLCNLISA 2398
+ + + + + + AE+L K E K + +L+ E+ KVN+ L L
Sbjct: 2215 NCVPQMAENISNLDNHLRAEELLKEFESEVKNK---ALRLEELHSKVND----LKELTKN 2267
Query: 2399 VTTP----------------AKAIAAVKSGGAVLNGEGTATNTEEFWAN--KGLTSIKKD 2440
+ TP AK I V G + + +T E+F + T +++
Sbjct: 2268 LETPPDLQFIEADLMQKLEHAKEITEVAKG-TLKDFTAQSTQVEKFINDITTWFTKVEES 2326
Query: 2441 MTDISHGYEDLGLL-LKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAP 2499
+ + + L +KD EL ++ S + QE +++ + + T
Sbjct: 2327 LMNCAQNETCEALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLI 2386
Query: 2500 TDTEAV-----KTQVEQNKSFEAELKQNVNKVQE---------------------LKDKL 2533
EAV KTQ +S E +++ + QE L+ KL
Sbjct: 2387 KKHEAVSQLCSKTQASLQESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKL 2446
Query: 2534 TEL----------------LEENPDTPEAPRWKQM-------LTEIDSKWQELNQLTIDR 2570
+L + + T A KQ+ +T+ + ++Q + +
Sbjct: 2447 HDLQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKD 2506
Query: 2571 QQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSV--LGPLSIDPNMLNTQRQQVQILLQE 2628
+Q L++ ++ L F+ +L W+ E E + LG + +V++ L E
Sbjct: 2507 KQALQDCASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGE 2566
Query: 2629 FATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQA 2688
+ ++L+ GQ +LS G G + QL Q +T + C A
Sbjct: 2567 LLAARESLDKLSQRGQ-LLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQ---VA 2622
Query: 2689 IVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIK 2748
+ + + L+S+ + + ++L+ + + D + ++L Q + + + + ++K
Sbjct: 2623 LQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDIL--LMKGEGEVK 2680
Query: 2749 VAQALCEDLSAL-VKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQ 2807
+ A+ + AL + + + QLE + + + D+ + + L+S + + + +
Sbjct: 2681 LNMAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVE 2740
Query: 2808 MSRDFQAWLDTKKEEQNKSHPISAK---------LDVLESLIKDHKDFSKTLTAQSHMYE 2858
+ W+++ +Q HP+ + LD L+S++ + +D ++ L
Sbjct: 2741 RKNQLEQWMESV--DQKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRAL-------H 2791
Query: 2859 KTIAEGENLLLKTQG-SEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQ 2917
+ IA+ L KT+ S K Q +L KT ++ KE+ K++E ++ L Y +
Sbjct: 2792 RLIAKSRELYEKTEDESFKDTAQEEL---KTQFNDIMTVAKEKMRKVEEIVKDHLMYLDA 2848
Query: 2918 VETLWPWIDKC-----------------QNNLEEIKFCLDPAE-GENSIAKLKSLQKEMD 2959
V W+ Q L +IK +D E G + +++++SL E+
Sbjct: 2849 VHEFTDWLHSAKEELHRWSDMSGDSSATQKKLSKIKELIDSREIGASRLSRVESLAPEVK 2908
Query: 2960 QHFGM--VELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQK 3017
Q+ EL++ +L + + ++ V L V + + + Q
Sbjct: 2909 QNTTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQA 2968
Query: 3018 FKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKR 3077
++F + K +QL + + + + + L LQ + + LK Q++ R
Sbjct: 2969 LEQFSALLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCR 3028
Query: 3078 LAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREM 3137
++DL + G + +E++ L Q + C E LQ +
Sbjct: 3029 FSRDLSTYSGKVSG----------LIKEYNCLCLQASKGCQNKEQILQ---------QRF 3069
Query: 3138 FSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEE 3197
F +F L + + + + L+K++ ++ ++N MML+ E
Sbjct: 3070 RKAFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSKGE 3129
Query: 3198 TSPDLV------GIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILL 3251
L+ GI+ + A + +E +E ++++F + L
Sbjct: 3130 LLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWL 3189
Query: 3252 QKAEE--HEESQGPVGMETETINQQLNMFKVFQKEEIEP----LQGKQQDVNWLGQGLIQ 3305
K E+ HE S + + QQ + + EP L+ K Q + W GQ
Sbjct: 3190 SKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQL-WEGQ---- 3244
Query: 3306 SAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDT 3365
+A+KS H + +++++ L+ ++ ++L + +F ++ L WM D
Sbjct: 3245 AASKS-----FRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDA 3299
Query: 3366 EELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKI 3425
++ + P+++ V+ ++ + + L + +++ +++I GE + P I
Sbjct: 3300 IHMLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTI 3359
Query: 3426 LKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIG 3485
+QL + W +LL+ QLEG + + + + W+ ++E L E
Sbjct: 3360 QQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQH 3419
Query: 3486 TQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWY 3545
+ + + K L +++++++ L G + + + Q +L Q Y
Sbjct: 3420 AELRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMT------EHYVTQLELQDLQERY 3473
Query: 3546 IEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQS 3605
IQE++ ++ + + + D WL + +KL + SV + ++
Sbjct: 3474 RAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAH---THET 3530
Query: 3606 ELRVLQEDILLRKQNVDQALLNG-LELLKQTTGDEVLIIQDK-LEAIKARYKDITKLSTD 3663
LR LQE L QALLN L + + +D+ LE+++ ++ ++
Sbjct: 3531 TLRDLQE--LQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSE 3588
Query: 3664 VAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEA 3723
+ R + +++ WL E E +S T+ + Q+ ++KK
Sbjct: 3589 TRTQFNNVVNKLRLMEQKFQQVDEWLKTAE-EKVSPRTRRQSNRATKEIQLH--QMKKWH 3645
Query: 3724 KNNKALLDSLNEVSSALLELVPW---RAREGLEKMVAEDNERYRLVSDTITQKVEEIDAA 3780
+ A D + EV + E++ +R G + + RY+ + + ++++ ++
Sbjct: 3646 EEVTAYRDEVEEVGARAQEILDESHVNSRMGCQ--ATQLTSRYQALLLQVLEQIKFLEEE 3703
Query: 3781 ILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEIL-----RH 3835
I ++ + + + W T K + + + D+ + +K T+E+L +
Sbjct: 3704 IQSLEESESSLSSYSDWYGSTHKNFKN---VATKIDKVDTVMMGKKLKTLEVLLKDMEKG 3760
Query: 3836 KDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQ 3895
++ + G + + E E + ++K++ ++ + + ++ LE+ L +
Sbjct: 3761 HSLLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKE 3820
Query: 3896 FWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTG 3955
F + + L W+ E Q I+ P +E + Q +++ L++ + H+P + + + G
Sbjct: 3821 FSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKG 3880
Query: 3956 PQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESL 4015
LLEL + ++++K + Y + K+ +L+ + ++ ++ ++ + L
Sbjct: 3881 EALLELV--QDVTLKDKIDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWL 3938
Query: 4016 ERIVERLRQPPSI-SAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTD 4074
++ RL P + ++ +E I +Q++ +K + ++ + L+ +G+ +I +
Sbjct: 3939 LQMSGRLVAPDLLETSSLETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQC---- 3994
Query: 4075 KDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCD-------HMSLIVT 4127
A +Q KL Q N+H ++ + + A++ + H+S T
Sbjct: 3995 ----ADHLQAKLKQ------NVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDT 4044
Query: 4128 IKDTQDFIRDLEDPGIDPSVVKQQQEAAETIRE--EIDGLQEELDIVINLGSELIAACGE 4185
++ Q ++ ++ P ++PS + AE I++ LQE+ ++L L + C +
Sbjct: 4045 LQQCQAWLSAVQ-PDLEPSP-QPPLSRAEAIKQVKHFRALQEQARTYLDL---LCSMC-D 4098
Query: 4186 PDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLA 4245
VK + ++ ++ + ++ + + Q + + ++ ++ A +L
Sbjct: 4099 LSNASVKTTAKDIQQTEQTIEQ----KLVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQ 4154
Query: 4246 SMSPIGTDLET--VKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQD 4303
+M ++LE + + ++K F + +Q + + + L KK EES +H +
Sbjct: 4155 NMKRRHSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKK--EESPEHKEIN 4212
Query: 4304 PLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGD 4363
L + W L + N + E L + ++ + +L +
Sbjct: 4213 HLNDQ---WLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWDNLARSDAE 4269
Query: 4364 PKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQN 4423
A+ +E K L + + +E + +IE ++ ++ + L QRW
Sbjct: 4270 STAVHLEALKKLALA--LQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQ 4327
Query: 4424 VLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVH 4483
+ + +++ Q L + ++L +W + + ++ + P+ A+ L H
Sbjct: 4328 LEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDH 4387
Query: 4484 MEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTK 4543
+ +C+ EAK+ KSL++ +++A + I + +++ + + + +R+
Sbjct: 4388 LAICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKY 4447
Query: 4544 LEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHR 4603
L +AL+ +F ++ + + Q E+ + L+ D V Q+ K + +++
Sbjct: 4448 LNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQ 4507
Query: 4604 EQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQF 4663
++ L G L +Q+ + L +QS ++ V+Q+ R + L+ K F
Sbjct: 4508 NEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHF 4567
Query: 4664 HEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGR 4723
E + K WL++++ E+ + N+ ++ TQLA+++ + ++ T RTG+
Sbjct: 4568 KEDFDKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQ 4627
Query: 4724 SLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDW 4783
++ + D + L + L+ L +++ I + ++ K++EA+L ++ ++
Sbjct: 4628 TILPSLNEVDHSY-LSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLIELTTQS 4686
Query: 4784 LYRVEPQLAEDQPVHGD--IDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRD 4841
L +E Q V D ++ ++L D +A E+ +V L + EG R
Sbjct: 4687 LSELEAQFLRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVDELNQKK----EGFRS 4742
Query: 4842 DSS-WVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWL--AEAEQT 4898
W +M L T + + + + + LE +E + L L + EQ+
Sbjct: 4743 TGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQS 4802
Query: 4899 LRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHW 4958
LP +E + + L++ L + T + + P + +H
Sbjct: 4803 KVNEETLPAEEK-----LKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQ 4857
Query: 4959 ITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLT-----DKDK 5013
I + + + + + S + I Q + L WL+ + L+ D +
Sbjct: 4858 IQSWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELSGPVYLDLNL 4917
Query: 5014 EVIPQEIEEVKALIAEHQTFMEEMTR-KQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGR 5072
+ I +EI +++ E Q+ + M + +K TK + +AD + + LD
Sbjct: 4918 QDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELDGDI 4977
Query: 5073 AGRKRFPASSLYPSGSQTQIETKNPRVNLLVSKWQQVWLLALERRRKLNDALDRLEELRE 5132
R ++L SQ Q ++ QV+ A ND L+ +EL +
Sbjct: 4978 QEALRTRQATLTEIYSQCQ-------------RYYQVFQAA-------NDWLEDAQELLQ 5017
Query: 5133 FANFDFDI 5140
A D+
Sbjct: 5018 LAGNGLDV 5025
Score = 320 bits (820), Expect = 2e-86
Identities = 889/4830 (18%), Positives = 1871/4830 (38%), Gaps = 684/4830 (14%)
Query: 648 VQDLLNWVDEMQVQLDRTE-WGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMT 706
V+ W+D M+ L+ +E ++L + L K ++ + + S L+ ++ MT
Sbjct: 3398 VRQFSGWMDSMEANLNESERQHAELRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMT 3457
Query: 707 ----APLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNEL-IWLNEKEEE 761
L+L ++ +R + AK T + L LH R +WL +++E+
Sbjct: 3458 EHYVTQLELQDLQERYRAIQERAKEAVTKSEK---LVRLHQEYQRDLKAFEVWLGQEQEK 3514
Query: 762 EVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENH---PARLTIEA 818
Y E + + H +R+L + + + Q + +L P+ +
Sbjct: 3515 LDQYSVLEGDAHT------HETTLRDLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAE 3568
Query: 819 YRAAMQTQWSWILQLCQCVEQHIKENTAYFE--------FFNDAKEATDYLRNLKDAIQR 870
RA + W Q + + E F ++ ++L+ ++ +
Sbjct: 3569 DRALESLRQDW-----QAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVSP 3623
Query: 871 KYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSI 930
+ R S+ E + + + EE+ Y+ + + +A+ I+ NS + +
Sbjct: 3624 RTR--RQSNRATKEIQLHQMKKWHEEVTAYRDEVEEVGARAQEILDESHVNSRMGCQAT- 3680
Query: 931 PIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVD 990
+ Y+ + + + + + + + ++ S +E+ + S +K +
Sbjct: 3681 --QLTSRYQALLLQVLEQIKFL--------EEEIQSLEESESSLSSYSDWYGSTHKNFKN 3730
Query: 991 LANRIEQ-----QYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEH 1045
+A +I++ + + TL + +K + H L+ R ++K + GE
Sbjct: 3731 VATKIDKVDTVMMGKKLKTL----EVLLKDMEKGHSLLKSA---REKGERAVKYLEEGEA 3783
Query: 1046 QQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQY-------------YQELL 1092
++ L+ D +E +E + LEK +++ K++ YQE+L
Sbjct: 3784 ER----LRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEIL 3839
Query: 1093 KSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKL 1152
E + E +S+ ++++ + + E ++ +R + E++ + + L
Sbjct: 3840 HVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPS-VKSVR------EKGEALLELVQDVTL 3892
Query: 1153 KKELERLKDDLGTITNKCEEF-FSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYI--D 1209
K ++++L+ D + + +E FS A SEL V + + Q MS + D
Sbjct: 3893 KDKIDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQ---MSGRLVAPD 3949
Query: 1210 KLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADK-NNIENLISTL-KQWRSEVDEK-R 1266
L+T +L Q A + + EE A D+ NN++ TL Q + K +
Sbjct: 3950 LLETSSLETITQQLA------HHKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLK 4003
Query: 1267 QVFHA-LEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQL--VERWQNVHVQIDNR-- 1321
Q HA L+ AI + Y+ + + H + D L + W + VQ D
Sbjct: 4004 QNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSA-VQPDLEPS 4062
Query: 1322 ----LRDLEGIGKSLKYYRDTYHPLDDWIQ-----------QVETTQRKIQENQPENSKT 1366
L E I K +K++R ++ V+TT + IQ+ + +T
Sbjct: 4063 PQPPLSRAEAI-KQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTE----QT 4117
Query: 1367 LATQLNQQKMLVS---EIEMKQSKMDECQKYAEQYSATVK--DYELQTMTYRAMVDSQQK 1421
+ +L Q + L EI+ +S++ + A+Q +K EL+ + MV +
Sbjct: 4118 IEQKLVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKD 4177
Query: 1422 SPVKRRRMQSSADLIIQEFMDLRTR-----YTALVTLMTQYIKFAGDSLKRLEEEEKSLE 1476
K + Q+S + II++ L + + + L Q++ S + E+ L+
Sbjct: 4178 FVKKLQSKQASVNTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDLQ 4237
Query: 1477 EEKKEH-------VEKAKELQKWV----SNISKTLKDAEKAGKPPFSKQ--KISSEEIST 1523
+ H V K +W S+ T E K + Q K + E++
Sbjct: 4238 RTRDYHDCMNVVEVFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQERKYAIEDLKD 4297
Query: 1524 KKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVK-------TLQESYNLL---FSESL 1573
+K+++ E L L K ++ +LE +K T E N++ F E +
Sbjct: 4298 QKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELM 4357
Query: 1574 KQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTE---NRLIGHQEAFMIGDGT 1630
+ +E Q + +++ + Q IC L + LI + M G
Sbjct: 4358 EWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGL 4417
Query: 1631 VELKKYQS------------------KQEELQKDMQGSAQALAEVVKNTENFLKENGEKL 1672
E + Q +++ L K + Q L V + T + + +
Sbjct: 4418 NERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIM 4477
Query: 1673 SQEDKALIEQKLNEAKIKCE--QLNLKAEQSK--------KELDKVVTTAIKEETEKVAA 1722
+E L+ +++ C+ Q +LK Q++ +EL K VT E EK
Sbjct: 4478 FREHICLLPDDVSKQVKTCKSAQASLKTYQNEVTGLWAQGRELMKEVT-----EQEKSEV 4532
Query: 1723 VKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNG 1782
+ +L+E ++ +++L K S R K ++ + HF+E + D+
Sbjct: 4533 LGKLQELQSVYDSVLQ------KCSHRLQELEKNLVSRK--HFKE--------DFDKACH 4576
Query: 1783 NLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPE 1842
L + D+ N + + A+++ I+ Q ++ + L++ GQ + P
Sbjct: 4577 WLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEY----ENLLLTLQRTGQTILPS 4632
Query: 1843 EKEK----LQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQ 1898
E L + + L + +A ++ K + +QE + E+ ++ + Q
Sbjct: 4633 LNEVDHSYLSEKLNALPRQFNVIVALAKDKF---YKVQEAI----LARKEYASLIELTTQ 4685
Query: 1899 ELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGK 1958
L LEA ++ + T L E+ +S + R I + EA +++ G
Sbjct: 4686 SLSELEAQFLRMSKVPTDLA-----VEEALSLQDGCRAILDEVAGLGEAVDELNQKKEGF 4740
Query: 1959 VDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACE 2018
T + K+ H + L + + L+D YQ +E L L++ +
Sbjct: 4741 RSTGQPWQP--DKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVK 4798
Query: 2019 ATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLP-A 2077
SK E + + K L+ +L G + + LK+ L D L P A
Sbjct: 4799 EEQSKVNEETLPAEEK-----LKMYHSLAGSLQDSGIV---LKRVTIHLEDLAPHLDPLA 4850
Query: 2078 KNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQ 2137
+ + G + L+ ++ E + + + +S+ Q + LDW+ V++ L
Sbjct: 4851 YEKARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELSGP 4910
Query: 2138 GQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDL 2197
+ LN +Q+ I K + ++++ +NA++ K K+ ++ L+ + +L
Sbjct: 4911 VYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAEL 4970
Query: 2198 SARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTE-- 2255
S + + A + E+ ++ + + + + +LE Q L ++ G DV
Sbjct: 4971 SELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLED-AQELLQLAGNGLDVESAE 5029
Query: 2256 --LSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDT 2313
L +M+ ++E H +LE LHSL+ + P+ K + +K +L + + M
Sbjct: 5030 ENLKSHMEFFSTEDQFHS-NLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRD 5088
Query: 2314 IKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQE 2373
+ + + C Q +Q + + + +T KK+ F S E +KL E
Sbjct: 5089 SGAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLS----EFSLLKTSSSHEAEEKLSE 5144
Query: 2374 KWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKG 2433
+L +S V + + I A++ + L E T + + ++
Sbjct: 5145 HKAL------------------VSVVNSFHEKIVALEEKASQL--EKTGNDASKATLSRS 5184
Query: 2434 LTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKW 2493
+T++ + T + +D +L+D + E +K++KA E M+ LQ
Sbjct: 5185 MTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATE----MIDQLQ--------- 5231
Query: 2494 QQTPAPTDTEAVK----TQVEQNKSFEAELKQNVNKVQELKDKLTELLEEN--PDTPEAP 2547
+ P + +A K T +E + +F EL+Q + + L+ + +L++ P E P
Sbjct: 5232 DKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEP 5291
Query: 2548 RWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGP 2607
Q +T + + + + + +++ + +T +K W+ E + LG
Sbjct: 5292 PLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQETK---EYLGN 5348
Query: 2608 LSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQ----GILSRPGEDPSLRGIVKEQ 2663
+I+ ++ Q +++QILL E + E++ + G+ + + SL Q
Sbjct: 5349 PTIE---IDAQLEELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILPSELSL------Q 5399
Query: 2664 LAAVTQKWDSLTGQLSDRCDWIDQAIVKST----QYQSLLRSLSDKLSDLDNKLSSSLAV 2719
LA V + Q+ D+ ++Q+ S Q Q L + L+ L+ L K + +
Sbjct: 5400 LAEVALDL-KIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQA 5458
Query: 2720 STHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILK 2779
T + ++L+ E+ ++ L + L L++++ + +
Sbjct: 5459 KTDQKVLGEELDGCNSKLMELDAAVQKF------------LEQNGQLGKPLAKKIGKLTE 5506
Query: 2780 SFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKE------EQNKSHPISAKL 2833
+ ++AEN + L A + ++ +M W++ K N + + +
Sbjct: 5507 LHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQY 5566
Query: 2834 DVLESLIKDHKDFSKTLTAQSHMYEKTIA----EGENLLLKTQGSEKAALQLQLNTIKTN 2889
+ ++L+++ K+ L A + + + E + + G E L+ + N
Sbjct: 5567 ILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQN 5626
Query: 2890 WDTFNKQVKERENKLKE---SLEKA-----------LKYKEQV---ETLWPWIDKCQNNL 2932
K +K+ E +LK+ +LE+A L KEQ+ + L ++ + +
Sbjct: 5627 LQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKV 5686
Query: 2933 EEIKFCLDPAE-GENSIAKLK------SLQKEMD--QHFGMVELLNNTANSLLSVCEIDK 2983
+ ++ C E+ +A L LQ+E QH + + +++ +
Sbjct: 5687 QAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQC------NIMQAAVVQY 5740
Query: 2984 EVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHD 3043
E E K L Q ++ ++ K N+ QE+ + R + A++ +
Sbjct: 5741 EQYEQEMKHLQQLIEGAHREIEDKPVATSNI-------QELQAQISRHEELAQKIKGYQE 5793
Query: 3044 SLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIA 3103
+ S K LTM L + LA+ GT D+ ++
Sbjct: 5794 QIASLNSKCKMLTMKAKHATMLLTVTEVEGLAE--------------GTEDLDGELLPTP 5839
Query: 3104 QEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQK 3163
H ++ +C L + + + T E+ S A S +PV ++ +
Sbjct: 5840 SAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPA-----CRSPSPVANTDASVNQ 5894
Query: 3164 QKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLV-GIKRDLEALSKQCNKLLDR 3222
A+ + L A D A + E P L L L + L +
Sbjct: 5895 DI----AYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNV 5950
Query: 3223 AQAREEQVEGTIKRLEEFYSKLKEFS-----ILLQKAEEHEESQGPVGMETETINQQLNM 3277
++ + ++R +++ L+ S I L+ +E E + P E++ Q M
Sbjct: 5951 ISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSP---ESQMAEHQALM 6007
Query: 3278 FKVFQ-KEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQ--GLEHDLDDVNARWKTLNKKV 3334
++ ++EI LQ L + L+ + ++ + L+ L + R T+ K
Sbjct: 6008 DEILMLQDEINELQSS------LAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKA 6061
Query: 3335 AQRAAQLQEAL---LHCGRFQDALE-------SLLSWMVDTEELVANQKPPSAEFKVVKA 3384
+ + L+E L L R + AL+ L SW++ T+ + P E ++A
Sbjct: 6062 SGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEA 6121
Query: 3385 QIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAE 3444
Q L+D + VE+ KV L +LS+ + L KA
Sbjct: 6122 Q---------LMDCQNMLVEI--------------EQKVVALSELSVHNENL-LLEGKAH 6157
Query: 3445 TRN---------RQLEGISVVAQQ-FHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQ 3494
T++ R+L+G + Q+ H+ + LN T EK + + TQ+ ++E
Sbjct: 6158 TKDEAEQLAGKLRRLKGSLLELQRALHD--KQLNMQGTAQEKEESDVDLTATQSPGVQEW 6215
Query: 3495 IAQHKAL----EDDIINHNKHLHQAVSIGQSL-KVLSSREDKDMVQSKLDFSQVWYIEIQ 3549
+AQ + + K L Q ++ +SL + ++SR ++ ++Q E
Sbjct: 6216 LAQARTTWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSA-------AETS 6268
Query: 3550 EKSHSRSELLQQALC--NAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSEL 3607
+ + ++L Q L K ED++ M W +H Q++ST+ Q + L
Sbjct: 6269 GDAGEKPDVLSQELGMEGEKSSAEDQMR-MKW-ESLH--------QEFSTKQKLLQ-NVL 6317
Query: 3608 RVLQEDILLRKQNVDQALLNGLELLK-QTTGDEVLIIQDKLEAIKARYKDITKLSTDVAK 3666
QE +L + N LL+G+ L K + + L+ + +++++ S +
Sbjct: 6318 EQEQEQVLYSRPN---RLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKR 6374
Query: 3667 TLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNN 3726
Q++ L ++L+ TWLD VE L + L EE + L K+ K
Sbjct: 6375 ---QSIHLEQKLYDGVSATSTWLDDVEERL--FVATALLPEETETCLFNQEILAKDIKEM 6429
Query: 3727 KALLD-SLNEVSSALLELVPWRAREGLEKMVAEDN-----ERYRLVSDTITQKVEEIDAA 3780
+D + N S A E G + V ED R L+ + Q+ ++
Sbjct: 6430 SEEMDKNKNLFSQAFPE-------NGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKER 6482
Query: 3781 ILR--------------------------SQQFDQAADAELSWITETEKKLMSLGDIRLE 3814
+ + + F+Q ++ I + E L +E
Sbjct: 6483 LQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIE 6542
Query: 3815 QDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDT 3874
+ +LQV++ E+ + +D+ D+L+ + ++ ++K + ++ L++
Sbjct: 6543 LKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQN--LTLKSQYERALQDLAD 6600
Query: 3875 ICQINSERYL--------QLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYET 3926
+ + E+ E Q L+++ E ++ L + T+++ ++ + A++ ET
Sbjct: 6601 LLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKET 6660
Query: 3927 L----------------------------------RQQQEEHRQLRE---------LIAE 3943
QQE RQL L+ E
Sbjct: 6661 QFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEE 6720
Query: 3944 HKPHI-----------DKMNKTGPQLLE-LSPGEGFSIQEKYVAADTLYSQIKE------ 3985
++ + +N+ P+L + L G+ I ++ +Q+ E
Sbjct: 6721 NEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNT 6780
Query: 3986 -DVKKRAVALDEAISQSTQFHDKIDQILESLERIVERL----RQPPSISAEVEKIKEQIS 4040
+ K L+ + T++ + ++ L+ +RL +Q ++ E+E +++ ++
Sbjct: 6781 NKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLN 6840
Query: 4041 ENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLV 4100
S +++ L ++ G +++ K + ++ +L ++ W ++ T +
Sbjct: 6841 AFLEFSKEVDAQSSLKSSVLSTGNQLLRL-----KKVDTATLRSELSRIDSQWTDLLTNI 6895
Query: 4101 EEREAKL--LDVMELAEKFWCDH-MSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAET 4157
+ KL L + +L + MS I +++ D I + + + +
Sbjct: 6896 PAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKG 6955
Query: 4158 IREEIDGLQEELDIV----INLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRI 4213
+ +I+ Q +D V + + S+ + + DK + + +N +W L ++I
Sbjct: 6956 FKIDINCKQLTVDFVNQSVLQISSQDVES-KRSDKTDFAEQLGAMNKSWQILQGLVTEKI 7014
Query: 4214 DKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQ 4273
LE +++ +Y++ +Q + W + +L IG D +V+ +++ + +
Sbjct: 7015 QLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIG-DQASVQNALKDCQDLEDLIKA 7073
Query: 4274 QQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLAL 4333
++ E+E++ L++ E+ V L EL W +L+ + + L+ L
Sbjct: 7074 KEKEVEKIEQNGLALIQNKKEDVSS-IVMSTLRELGQTWANLDHMVGQLKILLKSVLDQW 7132
Query: 4334 GQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNK 4393
+ A D++ ++L LS + + G +A+++++ LQ+D+ + +++
Sbjct: 7133 SSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGS 7192
Query: 4394 AGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALR---QAKGFHGEIE 4450
N L++ L N L+ +N RW N+LE+ ++ Q L+ + K + +
Sbjct: 7193 ITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCA 7252
Query: 4451 DLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKS----LMQKGQQ 4506
Q D LL + + A +++ ++ C T K L + G+Q
Sbjct: 7253 STVQQQEDRTNELLKAATN---KDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQ 7309
Query: 4507 MLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLT 4566
+ + SA + I D +L + ++E L +++T L+ + F SL+ W+
Sbjct: 7310 LKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIV 7369
Query: 4567 QAEQTLNVASRP-SLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDV 4625
+AE+ L S L T+ +++E K + +S + L++ G L +++
Sbjct: 7370 EAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLPL--NDKEI 7427
Query: 4626 VLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSEL 4685
++NL W + + ER L + + F E ME+L ++E+ L +
Sbjct: 7428 KRMQNL----NRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKL--AV 7481
Query: 4686 EIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSEL 4745
EI+ + + Q H+ FQ + ++ + + G+ L E+ + DD + + L+ L
Sbjct: 7482 EISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQV-DDRDEFNLKLTLL 7540
Query: 4746 RDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEP-QLAEDQPVHGDIDLV 4804
++W + ++ +R+ ++ + ++ + + L WL V ++ V +
Sbjct: 7541 SNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQA 7600
Query: 4805 MNLIDN----HKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETV 4860
L D K F ++ G +V+A K+ L+ + ++ ++ E+ +W++
Sbjct: 7601 RTLFDEVQFKEKVFLRQQGSYILTVEAGKQL---LLSADSGAEAALQAELAEIQEKWKSA 7657
Query: 4861 CALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHK 4920
++ +L L+ E+ + LE L ++ L LPD + L + K
Sbjct: 7658 SMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQS--LPDHHEELHAEQMRCK 7715
Query: 4921 EFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRL 4980
E + +L + + + DT+ A D I+ + + +++ ++EE+ +Q++
Sbjct: 7716 ELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQI 7775
Query: 4981 ASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRK 5040
L E + L WL E+ ++ +I + IE++K + + EE+
Sbjct: 7776 GERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLK------KDYQEEIAIA 7829
Query: 5041 QPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETKNPRVN 5100
Q + ++ + +R A SH ++IE K +VN
Sbjct: 7830 QENKIQLQQMGERLAK-----ASH---------------------ESKASEIEYKLGKVN 7863
Query: 5101 LLVSKWQQVWLLALERRRKLNDALDRLEEL 5130
+WQ + L R +KL + L +++L
Sbjct: 7864 ---DRWQHLLDLIAARVKKLKETLVAVQQL 7890
Score = 317 bits (812), Expect = 2e-85
Identities = 750/4057 (18%), Positives = 1540/4057 (37%), Gaps = 494/4057 (12%)
Query: 1301 KEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQ 1360
+++A + E+ + + ++ ++ +E + ++ + L WI + E ++ +
Sbjct: 1417 QQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKELNALETS- 1475
Query: 1361 PENSKTLATQLNQQKMLVSEIEMKQSKM----DECQKYAEQY----SATVKDYELQTMTY 1412
S + Q++Q K+ + EIE K S + +E Q +A+ SA +K Q Y
Sbjct: 1476 ---SSAMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIKAKLTQIRRY 1532
Query: 1413 R---------------AMVDSQQKSPVKRRRMQSSAD--------------------LII 1437
+ QQK R++Q S ++
Sbjct: 1533 GEELREHAQCLEGTILGHLSQQQKFEENLRKIQQSVSEFEDKLAVPIKICSSATETYKVL 1592
Query: 1438 QEFMDLRTRYTALVTLMTQYIKFAGDSLKR--LEEEEKSLEEEKKEHVEKAKELQKWVSN 1495
QE MDL +L + +T + A + R +E +L+++ ++ + +AKE Q + N
Sbjct: 1593 QEHMDLCQALESLSSAITAFSASARKVVNRDSCVQEAAALQQQYEDILRRAKERQTALEN 1652
Query: 1496 ISKTLKDAEKA------------GKPPFSKQKISSEEISTKKE-QLSEALQTIQLFLAKH 1542
+ + EK K + IS++ + + E QL +ALQ + A
Sbjct: 1653 LLAHWQRLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEVVSQASF 1712
Query: 1543 GDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQT------SGDVKVEEKIVAERQ 1596
K+ + + K + L L+QL E + + + +VAE Q
Sbjct: 1713 YSKLLQLKESLFSVASKDDVKMMKL----HLEQLDERWRDLPQIINKRINFLQSVVAEHQ 1768
Query: 1597 QEYKEKLQG--------ICDLLTQTENRLIGHQEAFMIGD---GTVELKK--YQSKQEEL 1643
Q + E L + +L T +E ++ HQ A VE KK QS Q L
Sbjct: 1769 Q-FDELLLSFSVWIKLFLSELQTTSEISIMDHQVALTRHKDHAAEVESKKGELQSLQGHL 1827
Query: 1644 QKD-----------MQGSAQALAEVVKNTENFLKENGEKLSQ-----EDKALIEQKLNEA 1687
K +QG A+ ++ + ++ LS + A + L +
Sbjct: 1828 AKLGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLAEFLQSHASLSGILRQL 1887
Query: 1688 KIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDS 1747
+ E N + ++K + A++ +A L+ +K + L S+ + S
Sbjct: 1888 RQTVEATNSMNKNESDLIEKDLNDALQNAKALESAAVSLDGILSKAQYHLKIGSSEQRTS 1947
Query: 1748 ERAGTKH-----KQVIEQNGTHFQEGDG----KSAIGEEDEVNGNLLETDVDGQVGTTQE 1798
RA +++ GT E D K A ++ E LL++ D + T +E
Sbjct: 1948 CRATADQLCGEVERIQNLLGTKQSEADALAVLKKAFQDQKE---ELLKSIEDIEERTDKE 2004
Query: 1799 NLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEE---KEKLQKNMKELK 1855
L + ++ Q ++ +Q + + + + L+ + + ++ ++ ++ + + L+
Sbjct: 2005 RLKEPTRQALQQRLRVFNQLEDELNSHEHELCWLKDKAKQIAQKDVAFAPEVDREINRLE 2064
Query: 1856 VHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMT 1915
V ++ +L H Q + E+++ + LEN A + T
Sbjct: 2065 VTWDDT-------KRLIHENQGQCCGLIDLMREYQNLKSAVSKVLEN----ASSVIVTRT 2113
Query: 1916 KLKRQKSFSEDVISHKG----------DLRYITISGNRVLEAAKSCSKRDGGKVDTSATH 1965
+K Q+ H+ DL T G +L K D V T
Sbjct: 2114 TIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSELKKIHSSDFSLVKTDMES 2173
Query: 1966 R-----EVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEAT 2020
+V KL+ DR R S + D++ E S + + +
Sbjct: 2174 TVDKWLDVSEKLEENMDRLRVSLSIWD-------DVLSTRDEIEGWSNNCVPQMAENISN 2226
Query: 2021 ASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKND 2080
HL R E K + ++ ++ + +E+L L + +L D
Sbjct: 2227 LDNHL------------RAEELLKEFESEVKNKALRLEELHSKVNDLKELTKNL-ETPPD 2273
Query: 2081 IQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQV 2140
+Q D++ + E + L+ +S V+ ++++ W VE SL Q
Sbjct: 2274 LQFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCAQ- 2332
Query: 2141 PLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSAR 2200
N T + + K +++++ +QS+I++ E + + SL M L +
Sbjct: 2333 --NETC--EALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKK 2388
Query: 2201 FSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKD-VTELSQY 2259
S +T A ++E K E++ E + FL K A D G V E +
Sbjct: 2389 HEAVSQLCSKTQASLQESLEK-HFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLH 2447
Query: 2260 -MQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKK 2318
+Q + + L+ + + + +H + + E+ +++F+ + K
Sbjct: 2448 DLQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDK 2507
Query: 2319 EAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLK 2378
+A+ C +L +F+ + L WI E ++ F E+LG+S + + K
Sbjct: 2508 QALQDCASELGSFEDQHRKLNLWIHEMEER-------FNTENLGESKQHIPE-------K 2553
Query: 2379 TPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIK 2438
E+ KV + L L++A +++ + G +L+ EG E ++ LTS
Sbjct: 2554 KNEVHKVE---MFLGELLAA----RESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTS-- 2604
Query: 2439 KDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPA 2498
+++L + K+K+ L + + +E +M W++ + + T
Sbjct: 2605 ---------HQNLLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLG 2655
Query: 2499 PTDTEAVKTQVEQN---KSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTE 2555
DT + Q+ E E+K N+ + + + L +E + L
Sbjct: 2656 SKDTLEKRLSQIQDILLMKGEGEVKLNM-AIGKGEQALRSSNKEGQRVIQT-----QLET 2709
Query: 2556 IDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNML 2615
+ W ++ ++ Q LE + + + QL+QW+ + + PL P +
Sbjct: 2710 LKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKIE--HPLQPQPGLK 2767
Query: 2616 N--TQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDS 2673
+Q +L E +L A + + + ED S + +E+L TQ D
Sbjct: 2768 EKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKT-EDESFKDTAQEELK--TQFNDI 2824
Query: 2674 LTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETA 2733
+T ++ +++ + Y + +D L +L +S A ++L
Sbjct: 2825 MT-VAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDSSATQKKLS-- 2881
Query: 2734 QKMKQEIQQEKKQIKVAQ-ALCEDLSALVKE-------EYLKAELSRQLEGILKSFKDVE 2785
K+K+ I + ++I ++ + E L+ VK+ E + E+ + L K ++D
Sbjct: 2882 -KIKELI--DSREIGASRLSRVESLAPEVKQNTTASGCELMHTEM-QALRADWKQWEDSV 2937
Query: 2786 QKAENHVQHLQSACASSHQ--------FQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLE 2837
+ ++ +++L S A S Q +Q F A L T ++ L +LE
Sbjct: 2938 FQTQSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQ----------LTLLE 2987
Query: 2838 SLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQV 2897
D + Q + AE LK+Q +E L+T K+
Sbjct: 2988 GKNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSGLIKEY 3047
Query: 2898 -----------KERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGEN 2946
+ +E L++ KA + +Q W+ + + C D + +
Sbjct: 3048 NCLCLQASKGCQNKEQILQQRFRKAFRDFQQ------WLVNAKITTAK---CFDIPQNIS 3098
Query: 2947 SIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQ-KVDMVTEQ-- 3003
++ SLQK + + E + N +LS E+ ++T E IQ KV E
Sbjct: 3099 EVST--SLQK-IQEFLSESENGQHKLNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWK 3155
Query: 3004 -----LHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDS---LGSQAYSNKYL 3055
LH K+ LEN+ + K+F EVS E + E++ +H+S L +
Sbjct: 3156 NFHSNLHQKESALENLKIQMKDF-EVSAEPIQDWLSKTEKM-VHESSNRLYDLPAKRREQ 3213
Query: 3056 TMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDE 3115
LQ+ + + + Q++ K AQ L + SK +V ++ ++ LS E
Sbjct: 3214 QKLQSVLEEIHCYEPQLNRLKEKAQQLWEGQAASKSFRH---RVSQLSSQYLALSNLTKE 3270
Query: 3116 KCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKL 3175
K S L+ + F I+E+ + LDS D L + KL
Sbjct: 3271 KVSRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRT-------LKL 3323
Query: 3176 EALMASNDNANKTCKMMLATEE-----TSPD-LVGIKRDLEALSKQCNKLLDRAQAREEQ 3229
EAL++ KM++ E TSP+ + I++ L+++ LL + Q
Sbjct: 3324 EALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQ 3383
Query: 3230 VEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPL 3289
+EG + + + +++FS + E + E L K+ EE+
Sbjct: 3384 LEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHAELRDKTTMLGKAKLLN-EEVLSY 3442
Query: 3290 QGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCG 3349
+ + G G+ T + +L D+ R++ + ++ + + ++ +
Sbjct: 3443 SSLLETIEVKGAGM-------TEHYVTQLELQDLQERYRAIQERAKEAVTKSEKLVRLHQ 3495
Query: 3350 RFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKRE 3409
+Q L++ W+ +E + + + +++ + LQ + ++ + +
Sbjct: 3496 EYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVLHT 3555
Query: 3410 GEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNE 3469
E + + P + + L+ L W+A ++ Q + + + + ++E
Sbjct: 3556 REDVIPSGIPQAEDRALESLR---QDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDE 3612
Query: 3470 WLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSRE 3529
WL T E+++ + + E Q+ Q K +++ + + + + Q +
Sbjct: 3613 WLKTAEEKVSPRTRRQSNRATKEIQLHQMKKWHEEVTAYRDEVEEVGARAQEIL------ 3666
Query: 3530 DKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELM-----------N 3578
D+ V S++ + + + LL Q L K F E+E++ + +
Sbjct: 3667 DESHVNSRMG------CQATQLTSRYQALLLQVLEQIK-FLEEEIQSLEESESSLSSYSD 3719
Query: 3579 WLNEVHDKLSKLS--VQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTT 3636
W H ++ + T + K+ L VL +D+ + A G +K
Sbjct: 3720 WYGSTHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLE 3779
Query: 3637 GDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVEL 3696
E ++ ++ + K++T TLE+ L LA+ + L W+ + + L
Sbjct: 3780 EGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEIL 3839
Query: 3697 LSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMV 3756
E ++ E + K L++ +++ + S+ E ALLELV L+ +
Sbjct: 3840 HVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLELVQ---DVTLKDKI 3896
Query: 3757 AEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQD 3816
+ Y+ + + V ++A + + ++ W+ + +L++ +
Sbjct: 3897 DQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQMSGRLVAPDLLETSSL 3956
Query: 3817 QT-SAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLK----N 3871
+T + QL K EI +D +++L G ++ C++ + +K+ + L+ +
Sbjct: 3957 ETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDS 4016
Query: 3872 YDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPAL-------EY 3924
Y IC Y LE +T ++ WL+ Q + P P L +
Sbjct: 4017 YSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQV 4076
Query: 3925 ETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTL---YS 3981
+ R QE+ R +L+ + KT + ++ + +I++K V A L +
Sbjct: 4077 KHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQ---TIEQKLVQAQNLTQGWE 4133
Query: 3982 QIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISE 4041
+IK + + L +A DQ L++++R L E+ + +S+
Sbjct: 4134 EIKHLKSELWIYLQDA-----------DQQLQNMKRRHSEL--------ELNIAQNMVSQ 4174
Query: 4042 NKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVE 4101
K+ ++ Q T+ ++ ++ + + K + DQ + + + L
Sbjct: 4175 VKDFVKKLQSKQASVNTIIEKVNKLTKKEESPEH----KEINHLNDQWLDLCRQSNNLCL 4230
Query: 4102 EREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIR----DLEDPGIDPSVVKQQQEAAET 4157
+RE D+ + C ++ + K T ++ D E + +K+ A +
Sbjct: 4231 QREE---DLQRTRDYHDCMNVVEVFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQE 4287
Query: 4158 IREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLE 4217
+ I+ L+++ ++I DK +VK+ L W L K +I
Sbjct: 4288 RKYAIEDLKDQKQ-------KMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQVSV 4340
Query: 4218 EAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIE 4277
++ Q Q + +W + +A E LKQ Q +
Sbjct: 4341 TNLEELNVVQSRFQELMEWAEEQQPNIA----------------EALKQSPPPDMAQNLL 4384
Query: 4278 MERLNHQAEL-----LLKKVTEESDK----------HTVQDPLMELKLIWDSLEERIINR 4322
M+ L +EL LLK + +++D+ +Q L + + + L + + R
Sbjct: 4385 MDHLAICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQR 4444
Query: 4323 QHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVL 4382
+ L AL QF A+ + + + E + ++ + P + ++ Q +
Sbjct: 4445 RKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLK 4504
Query: 4383 AHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQA 4442
+Q+ V + G +L++ +E S + KL+ L + +VL+K R Q+L+ L
Sbjct: 4505 TYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSR 4564
Query: 4443 KGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQ 4502
K F + + WL + L QL + + E +L +
Sbjct: 4565 KHFKEDFDKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQR 4624
Query: 4503 KGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFI 4562
GQ +L + + + + +N L ++ + ++ K++EA+ E+ + ++
Sbjct: 4625 TGQTILPSLNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLIELTT 4684
Query: 4563 NWLTQAE-QTLNVASRPS-LILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFS 4620
L++ E Q L ++ P+ L ++ L D + +EV E + EL++ +
Sbjct: 4685 QSLSELEAQFLRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVDELNQKKEGFRSTG 4744
Query: 4621 QKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKS 4680
Q + ++ + + + ++ ++ +R L+D A Q HE K+ + LE KS
Sbjct: 4745 QPWQ----PDKMLHLVTLYHRLKRQTEQRVSLLEDTTS-AYQEHE---KMCQQLERQLKS 4796
Query: 4681 LDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNL---- 4736
+ E N+ +T A+ K L HS+ + +G LK T +D
Sbjct: 4797 VKEEQSKVNE----ETLPAEEK-----LKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLD 4847
Query: 4737 -----KLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQL 4791
K + + + + E + E ++ S F + +DWL RV+ +L
Sbjct: 4848 PLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAEL 4907
Query: 4792 AEDQPVHGDIDL--VMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRD-DSSWVKV 4848
+ PV+ D++L + I + Q+E+ + AL +E +++ S+ ++
Sbjct: 4908 SG--PVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEH 4965
Query: 4849 QMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDD 4908
+ ELS + ++Q L Q + ++ V A +WL +A++ L+ G D
Sbjct: 4966 SLAELSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDV 5025
Query: 4909 EDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEE 4968
E A L H EF ++ + L + ++ T+ + P + E+
Sbjct: 5026 ESAEENL-KSHMEFFSTEDQFHSNLEELHSLVATLDPLIKPTG-----------KEDLEQ 5073
Query: 4969 VLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIA 5028
+A + QR++ A+ +LL+ A QW + K +E + + + + + ++
Sbjct: 5074 KVASLELRSQRMSRDSG---AQVDLLQRCTA--QWHDY---QKAREEVIELMNDTEKKLS 5125
Query: 5029 EHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGS 5088
E F T + ++ +K + +S I L++ AS L +G+
Sbjct: 5126 E---FSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEE--------KASQLEKTGN 5174
Query: 5089 QTQIETKNPRVNLLVSKWQQVWLLALERRRKLNDALD 5125
T + + + +W ++ +A ++ + L DA+D
Sbjct: 5175 DASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVD 5211
Score = 303 bits (776), Expect = 3e-81
Identities = 735/4084 (17%), Positives = 1585/4084 (38%), Gaps = 481/4084 (11%)
Query: 1152 LKKELERLKDDLGTITNKCEEFFS--QAAASSSVPTLRSELNVVLQNMNQVYSMSSTYID 1209
++++LE+ KD L F + + + +P +L + + + V S S ++
Sbjct: 442 IQRKLEQHKDLLQNTDAHKRAFHEIYRTRSVNGIPVPPDQLEDMAERFHFVSSTSELHLM 501
Query: 1210 KLKTVNL---VLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKR 1266
K++ + L +L AE+ +K + K E+V + ++N +S + E
Sbjct: 502 KMEFLELKYRLLSLLVLAESKLKSWIIKYGRRESV---EQLLQNYVSFI--------ENS 550
Query: 1267 QVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVE-------RWQNVHVQID 1319
+ F E ++ ++ K E + D E+A+ +++ +W+N+ V++
Sbjct: 551 KFFEQYE--------VTYQILKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNLSVEVR 602
Query: 1320 NRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVS 1379
+ LE + + Y +T L W++ E NQ EN+K + N +
Sbjct: 603 SVRSMLEEVISNWDRYGNTVASLQAWLEDAEKML-----NQSENAKKDFFR-NLPHWIQQ 656
Query: 1380 EIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKS---PVKRRRMQSSADLI 1436
M + + E S +K L +++ + + VK+ D +
Sbjct: 657 HTAMNDAGNFLIETCDEMVSRDLKQQLL-------LLNGRWRELFMEVKQYAQADEMDRM 709
Query: 1437 IQEFMDLRTRYTALVT----LMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKW 1492
+E+ D +A T +++ ++ + ++K L ++ + +E+ + K + K
Sbjct: 710 KKEYTDCVVTLSAFATEAHKKLSEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQYKIITKT 769
Query: 1493 VSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERN 1552
I+K + ++ GK F+ E+++ KE S L Q L
Sbjct: 770 AHLITK--ESPQEEGKEMFATMSKLKEQLTKVKECYSPLLYESQQLLIP---------LE 818
Query: 1553 ELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQ 1612
ELEKQ+ + +S + +E+Q+S K + + + Q+ K+ L
Sbjct: 819 ELEKQMTSFYDSLGKINEIITVLEREAQSSALFKQKHQELLACQENCKKTLT-------- 870
Query: 1613 TENRLIGHQEAFMIGDGTVELKKYQSKQEELQK-DMQGSAQALAEVVKNTENFLKENGEK 1671
+I G+ ++K+ + L+ D + +A++ ++ +K+ G+
Sbjct: 871 ------------LIEKGSQSVQKFVTLSNVLKHFDQTRLQRQIADIHVAFQSMVKKTGDW 918
Query: 1672 LSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKT 1731
K +E +L K E+S+ EL+KV+ A +E E+ ++L T
Sbjct: 919 -----KKHVETN--------SRLMKKFEESRAELEKVLRIA-QEGLEEKGDPEELLRRHT 964
Query: 1732 KIENLLD------WLSNVDKDSERAGTKHKQVIEQ--NGTHFQEGDGKSAIGEEDEVNGN 1783
+ + LD +L D+ ++ + +Q +++ H Q D + E +
Sbjct: 965 EFFSQLDQRVLNAFLKACDELTDILPEQEQQGLQEAVRKLHKQWKD------LQGEAPYH 1018
Query: 1784 LLETDVDGQ----VGTTQENLNQQYQKVKAQ----HEKIISQHQAVIIATQSAQVLLEKQ 1835
LL +D + + + +E + ++ K EKII +H+ V + + L EK+
Sbjct: 1019 LLHLKIDVEKNRFLASVEECRTELDRETKLMPQEGSEKIIKEHR-VFFSDKGPHHLCEKR 1077
Query: 1836 GQYLSPEE---KEKLQKNMKELKVHYETALAESEKKMKLTH-SLQEELEKFDADYT---- 1887
Q + EE K ++ +++ L E + T+ L E+ +K+ DYT
Sbjct: 1078 LQLI--EELCVKLPVRDPVRDTPGTCHVTLKELRAAIDSTYRKLMEDPDKWK-DYTSRFS 1134
Query: 1888 EFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEA 1947
EF W+ +E +L+ ++ A D ++KR + ++ +G+ S +VL
Sbjct: 1135 EFSSWISTNETQLKGIKGEAID-TANHGEVKRAVEEIRNGVTKRGETLSWLKSRLKVLTE 1193
Query: 1948 AKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDAS 2007
S + + + KL + +L S+ + +N D V + +++
Sbjct: 1194 VSS--------ENEAQKQGDELAKLSSSFKALVTLLSEVEKMLSNFGDCVQYKEIVKNSL 1245
Query: 2008 CGLLAGLQACEATASKHL-SEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEV 2066
L++G + + A K L +E + + L ++TK + + Q + + ++
Sbjct: 1246 EELISGSKEVQEQAEKILDTENLFEAQQLLLHHQQKTKRISAKKRDVQQQIAQAQQGEGG 1305
Query: 2067 LLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDW 2126
L D L ++ TLD L +S + ++Q+TL + + + ++ +
Sbjct: 1306 LPDRGHEEL---RKLESTLD-------GLERSRERQERRIQVTLRKWERFETNKETVVRY 1355
Query: 2127 MGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEK-VKKFME-TTDP 2184
+ SS + L+ ++L+ +S + ++ + R SI E VK+ E P
Sbjct: 1356 LFQTGSSHERF----LSFSSLES-LSSELEQTKEFSKRTESIAVQAENLVKEASEIPLGP 1410
Query: 2185 STASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALT 2244
LQ + K + + + +E + ME +KTK + F + E L ++ K + L
Sbjct: 1411 QNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKELN 1470
Query: 2245 EVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLS 2304
++ + ++ + E + L + + + A + K +
Sbjct: 1471 ALETSSSAMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIKAKLTQIR 1530
Query: 2305 KKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKS 2364
+ +E+ + + + + Q F+ ++ ++ + E
Sbjct: 1531 RYGEELREHAQCLEGTILGHLSQQQKFEENLRKIQQSVSE-------------------- 1570
Query: 2365 LEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATN 2424
ED + K E KV + LC + ++++ A +A S V+N +
Sbjct: 1571 FEDKLAVPIKICSSATETYKVLQEHMDLCQALESLSSAITAFSA--SARKVVNRD----- 1623
Query: 2425 TEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQ 2484
S ++ + YED+ K++ L L+ Q+ ++E S+ + WL+
Sbjct: 1624 -----------SCVQEAAALQQQYEDILRRAKERQTALENLLAHWQRLEKELSSFLTWLE 1672
Query: 2485 KMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTP 2544
+ A+ + D A + +VE L+ V KL +L E
Sbjct: 1673 RGEAKASSPEM-----DISADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESLFSVA 1727
Query: 2545 EAPRWKQM---LTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELM 2601
K M L ++D +W++L Q+ R L+ QF + W+
Sbjct: 1728 SKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFLSE 1787
Query: 2602 VSVLGPLSIDPNMLNTQRQ-----QVQILLQEFATRKPQYEQLTAAGQG----ILSRPGE 2652
+ +SI + + R +V+ E + + +L + G+ +L E
Sbjct: 1788 LQTTSEISIMDHQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQGKAE 1847
Query: 2653 D-----------PSLRGIVKEQLAAVTQKWDSLTGQL--------------SDRCDWIDQ 2687
D R + LA Q SL+G L + D I++
Sbjct: 1848 DCFQLFEEASQVVERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEK 1907
Query: 2688 AIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQI 2747
+ + Q L S + L + +K L + + + + TA ++ E+++ + +
Sbjct: 1908 DLNDALQNAKALESAAVSLDGILSKAQYHLKIGSSEQRTSCR-ATADQLCGEVERIQNLL 1966
Query: 2748 KVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQ 2807
Q+ + L+ LK Q E +LKS +D+E++ + + L+ + QQ
Sbjct: 1967 GTKQSEADALAV------LKKAFQDQKEELLKSIEDIEERTDK--ERLKE--PTRQALQQ 2016
Query: 2808 MSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENL 2867
R F D E + H + D + + + F+ + + + E T + + L
Sbjct: 2017 RLRVFNQLED---ELNSHEHELCWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRL 2073
Query: 2868 LLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDK 2927
+ + QG + L ++E +N LK ++ K L+ V I
Sbjct: 2074 IHENQGQCCGLIDL---------------MREYQN-LKSAVSKVLENASSVIVTRTTI-- 2115
Query: 2928 CQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFG----MVELLNNTANSLLSVCEIDK 2983
+ E++K+ ++ E + K+ QK++D ++ L +S S+ + D
Sbjct: 2116 --KDQEDLKWAF--SKHETAKNKMNYKQKDLDNFTSKGKHLLSELKKIHSSDFSLVKTDM 2171
Query: 2984 EVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHD 3043
E D+ + +K++ ++L +++ E + S Q+ LD H
Sbjct: 2172 ESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLDNH- 2230
Query: 3044 SLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIA 3103
L ++ ++ + ++ + L+ L +V+ K L ++L +D++ ++E A
Sbjct: 2231 -LRAEELLKEFESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEH-A 2288
Query: 3104 QEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQK 3163
+E + +++ + + T++ + I ++ + F + ++ L + A E L+K
Sbjct: 2289 KEITEVAKGTLKDFTAQSTQV------EKFINDITTWFTKVEESLMNCAQ-NETCEALKK 2341
Query: 3164 QKETIKAFLKKLEALMASNDNANKTCKMMLATEETS--PDLVGIKRDLEALSKQCNKLLD 3221
K+ K + + ++ +N N C+ + E S + G+ + EA+S+ C+K
Sbjct: 2342 VKDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQA 2401
Query: 3222 RAQ-AREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKV 3280
Q + E+ +++ +E++ K A+E + G + ++ N+
Sbjct: 2402 SLQESLEKHFSESMQEFQEWFLGAK------AAAKESSDRTGDSKVLEAKLHDLQNIL-- 2453
Query: 3281 FQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQ 3340
+ + Q K V GQ L +K ++ + N ++ K+ +
Sbjct: 2454 ---DSVSDGQSKLDAVTQEGQTLYAHLSKQI-VSSIQEQITKANEEFQAFLKQCLKDKQA 2509
Query: 3341 LQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKL---LQRLLD 3397
LQ+ G F+D L W+ + EE + ++ + + + + K+ L LL
Sbjct: 2510 LQDCASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLA 2569
Query: 3398 DRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVA 3457
R+S ++ + + G+ ++ A + L L + + K + R+ Q VA
Sbjct: 2570 ARES-LDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQ------VA 2622
Query: 3458 QQFHETLEPLNE----WLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNK--- 3510
Q HE LE + W+ I+ RL E LE++++Q ++D ++ +
Sbjct: 2623 LQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQ---IQDILLMKGEGEV 2679
Query: 3511 HLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFG 3570
L+ A+ G+ S++E + ++Q++L+ + + +I S L+ + +
Sbjct: 2680 KLNMAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYV 2739
Query: 3571 EDEVELMNWLNEVHDKL-----------SKLSVQDYSTEGLWKQQSELRVLQEDILLRKQ 3619
E + +L W+ V K+ K + D+ L + + R L I ++
Sbjct: 2740 ERKNQLEQWMESVDQKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRE 2799
Query: 3620 NVDQALLNGLELLKQTTGDEVLI-IQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRL 3678
++ E K T +E+ D + K + + + ++ D L+ + L
Sbjct: 2800 LYEK---TEDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWL 2856
Query: 3679 HSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSS 3738
HS EEL W D + G+ ++ +K+ K L+DS E+ +
Sbjct: 2857 HSAKEELHRWSD-------------MSGDSSA--------TQKKLSKIKELIDS-REIGA 2894
Query: 3739 ALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWI 3798
+ L V A E + A E + ++ + ++ ++Q + ++++ +
Sbjct: 2895 SRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMA-L 2953
Query: 3799 TETEKKLMSLGDIRLEQ--DQTSAQLQVQKTFTME--ILRHKDIIDDLVKSGHK---IMT 3851
+E E S +LEQ +Q SA L KT+ + +L K+ +++V+ HK I+
Sbjct: 2954 SEQE---FSGQVAQLEQALEQFSALL---KTWAQQLTLLEGKNTDEEIVECWHKGQEILD 3007
Query: 3852 AC--SEEEKQSMKKKLDK-----------------VLKNYDTICQINSERYLQLERAQSL 3892
A +E + +K +L++ ++K Y+ +C + + + Q + Q L
Sbjct: 3008 ALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSGLIKEYNCLC-LQASKGCQ-NKEQIL 3065
Query: 3893 VNQFWETYEELWPWLTE---TQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHID 3949
+F + + + WL T + +P E T Q+ +E L E +E+ H
Sbjct: 3066 QQRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEF--LSE--SENGQHKL 3121
Query: 3950 KMNKTGPQLLE--LSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDK 4007
M + +LL L+ + IQ K AA + ++ ++ AL+ Q F
Sbjct: 3122 NMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVS 3181
Query: 4008 IDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMI 4067
+ I + L + + + + + ++ + + + ++V ++ +P LK++ +++
Sbjct: 3182 AEPIQDWLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQL- 3240
Query: 4068 ARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVT 4127
+ ++K+ + ++ Q+ + + L +E+ ++L ++ +H +
Sbjct: 3241 -----WEGQAASKSFRHRVSQLSSQYLALSNLTKEKVSRL-------DRIVAEHNQFSLG 3288
Query: 4128 IKDTQDFIRDLE-------DPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELI 4180
IK+ QD++ D P D SV+ + E + + ++ +++ G ++
Sbjct: 3289 IKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVL 3348
Query: 4181 AACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIA 4240
P +++ + + W SL A +LE A+ YQDG++ W+D
Sbjct: 3349 QNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSM 3408
Query: 4241 GGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHT 4300
L +L + + K E +E + K ++ +
Sbjct: 3409 EANLNESERQHAELRDKTTMLGKAKLLNEEVLSYSSLLETIE-------VKGAGMTEHYV 3461
Query: 4301 VQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPV 4360
Q L +L+ + +++ER K E + ++Q L WL + L + +
Sbjct: 3462 TQLELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVL 3521
Query: 4361 GGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQR 4420
GD E L LQ Q+ + +V D+I S + LE L Q
Sbjct: 3522 EGDAHTHETTLRDLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAE---DRALESLRQD 3578
Query: 4421 WQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQL 4480
WQ + + + Q + + + + + + + +WL E + T + QL
Sbjct: 3579 WQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVSPRTRRQSNRATKEIQL 3638
Query: 4481 NV----HMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETK 4536
+ H EV A + EE + + Q++L + + L +++++ +
Sbjct: 3639 HQMKKWHEEVTAYRDEVEE----VGARAQEILDE--SHVNSRMGCQATQLTSRYQALLLQ 3692
Query: 4537 LNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTL-NVASRPSLILDTVLF--QIDEHK 4593
+ E+ LEE + E +SL + +W + NVA++ + DTV+ ++ +
Sbjct: 3693 VLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDKV-DTVMMGKKLKTLE 3751
Query: 4594 VFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSL 4653
V ++ + + G + ++ + ++ + + +++ + + +L
Sbjct: 3752 VLLKDMEKGHSLLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTL 3811
Query: 4654 DDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHS 4713
+ AK+F + L +W+ E ++ L E + + K QL+++K Q+++ +
Sbjct: 3812 EKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSHEP 3871
Query: 4714 VYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQF 4773
+ G +L E ++ L D + +L+ + +C E LE + +
Sbjct: 3872 SVKSVREKGEALLELV----QDVTLKDKIDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDY 3927
Query: 4774 TDALQALIDWLYRVEPQL-AEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSA 4832
LQ + WL ++ +L A D ++ + + +HKA +E+ + L+
Sbjct: 3928 NSELQEVEKWLLQMSGRLVAPDLLETSSLETITQQLAHHKAMMEEIAGFEDRLNNLQMKG 3987
Query: 4833 RELIEGSRDD-----SSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHA 4887
LI D V +Q + +C+ + LE L++ +
Sbjct: 3988 DTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQ 4047
Query: 4888 LLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAIC 4947
WL+ + L P + L E +K+++ RA +A T D + ++C
Sbjct: 4048 CQAWLSAVQPDLE-----PSPQPPL-----SRAEAIKQVKHFRALQEQARTYLDLLCSMC 4097
Query: 4948 HPD--SITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAE 5005
S+ T I E+ L A+ Q G + L L +LQ A+
Sbjct: 4098 DLSNASVKTTAKDIQQTEQTIEQKLVQAQNLTQ-------GWEEIKHLKSELWIYLQDAD 4150
Query: 5006 TTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDV----DKVTKTYKRRAADPSSL 5061
L + + E+ + ++++ + F++++ KQ V +KV K K+ +
Sbjct: 4151 QQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKKEESPEHKE 4210
Query: 5062 QSHI 5065
+H+
Sbjct: 4211 INHL 4214
Score = 296 bits (759), Expect = 3e-79
Identities = 757/4370 (17%), Positives = 1680/4370 (38%), Gaps = 541/4370 (12%)
Query: 1070 SGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQ 1129
S S + ++ V Q + L S E+E + +++ + R++ + + Q
Sbjct: 1475 SSSAMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIKAK------LTQ 1528
Query: 1130 IRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSE 1189
IR E H T L ++ ++ +++L I EF + A + + +E
Sbjct: 1529 IRRYGEELREHAQCLEGTILGHLSQQ-QKFEENLRKIQQSVSEFEDKLAVPIKICSSATE 1587
Query: 1190 LNVVLQN----MNQVYSMSSTYIDKLKTVNLVLKN---TQAAEALVKLYETKLCEE---- 1238
VLQ + S+SS + V+ Q A AL + YE L
Sbjct: 1588 TYKVLQEHMDLCQALESLSSAITAFSASARKVVNRDSCVQEAAALQQQYEDILRRAKERQ 1647
Query: 1239 ---EAVIADKNNIENLISTLKQW------------------RSEVDEKRQVFHALEDEL- 1276
E ++A +E +S+ W R +V+ + Q+ AL++E+
Sbjct: 1648 TALENLLAHWQRLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEVV 1707
Query: 1277 ------QKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGK 1330
K + + +F + D+ K +QL ERW+++ I+ R+ L+ +
Sbjct: 1708 SQASFYSKLLQLKESLFSVASKDDVKM--MKLHLEQLDERWRDLPQIINKRINFLQSVVA 1765
Query: 1331 SLKYYRDTYHPLDDWIQ----QVETTQR-KIQENQPENSKTLATQLNQQKMLVSEIEMKQ 1385
+ + + WI+ +++TT I ++Q L + K +E+E K+
Sbjct: 1766 EHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQ--------VALTRHKDHAAEVESKK 1817
Query: 1386 SKMDECQKYAEQYSATVKDYELQTMTYRA----MVDSQQKSPVKRRRMQSSADLIIQEFM 1441
++ Q + + + + +L + +A + + V+RR++ S + EF+
Sbjct: 1818 GELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSH---LAEFL 1874
Query: 1442 DLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLK 1501
+ ++ + Q ++ A +S+ + E + +E++ + ++ AK L+ ++ L
Sbjct: 1875 QSHASLSGILRQLRQTVE-ATNSMNKNESD--LIEKDLNDALQNAKALESAAVSLDGILS 1931
Query: 1502 DAEKAGKPPFSKQKIS----SEEISTKKEQLSEALQTIQ-----LFLAKHG--------- 1543
A+ K S+Q+ S ++++ + E++ L T Q L + K
Sbjct: 1932 KAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQSEADALAVLKKAFQDQKEELL 1991
Query: 1544 ------DKMTDEER----------------NELEKQVKTLQESYNLLFSESLKQLQESQT 1581
++ TD+ER N+LE ++ + + L + KQ+ +
Sbjct: 1992 KSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHELCWL-KDKAKQIAQKDV 2050
Query: 1582 SGDVKVEEKI---------VAERQQEYKEKLQGICDLLTQTEN------RLIGHQEAFMI 1626
+ +V+ +I E + + G+ DL+ + +N +++ + + ++
Sbjct: 2051 AFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVSKVLENASSVIV 2110
Query: 1627 GDGTV----ELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQ 1682
T+ +LK SK E + M + L ++ L E +K+ D +L++
Sbjct: 2111 TRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSEL-KKIHSSDFSLVKT 2169
Query: 1683 KLNEAKIKCEQLNLKAEQSKKEL-------DKVVTTAIKEETEKVAAVKQLEESKTKIEN 1735
+ K ++ K E++ L D V++T + E V Q+ E+ + ++N
Sbjct: 2170 DMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLDN 2229
Query: 1736 -------LLDWLSNVDKDSERAGTKHKQVIEQN----------GTHFQEGDGKSAIGEED 1778
L ++ S V + R H +V + F E D +
Sbjct: 2230 HLRAEELLKEFESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAK 2289
Query: 1779 EVNGNLLETDVDGQVGTTQ-----ENLNQQYQKVK------AQHE------------KII 1815
E+ T D +TQ ++ + KV+ AQ+E K +
Sbjct: 2290 EITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCAQNETCEALKKVKDIQKEL 2349
Query: 1816 SQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSL 1875
Q+ I +TQ L + E E L + M L +E A S+ K SL
Sbjct: 2350 QSQQSNISSTQEN---LNSLCRKYHSAELESLGRAMTGLIKKHE---AVSQLCSKTQASL 2403
Query: 1876 QEELEK-FDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDL 1934
QE LEK F EF+ W ++ + D L KL ++ + V + L
Sbjct: 2404 QESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKL 2463
Query: 1935 RYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLK 1994
+T G + ++ +S +Q ++ A + F++ +C L+
Sbjct: 2464 DAVTQEGQTLYAHLSK-------QIVSS-----IQEQITKANEEFQAFLKQCLKDKQALQ 2511
Query: 1995 DLVDKYQHYEDASCGLLAGLQACEATAS-KHLSEPIAVDPKNLQRQLEETKALQGQISSQ 2053
D + +ED L + E + ++L E P+ + ++ + + G++ +
Sbjct: 2512 DCASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEK-KNEVHKVEMFLGELLAA 2570
Query: 2054 QVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRS 2113
+ +++KL + + LL G + ++ +++L + E+ Q+ L
Sbjct: 2571 RESLDKLSQRGQ-LLSEEGH---GAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQVALQEH 2626
Query: 2114 LSVQDGLDEMLDWMGNVESSL--------------------------KEQGQVPLN---- 2143
++++ L M W+ ++ L K +G+V LN
Sbjct: 2627 EALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAIG 2686
Query: 2144 -----------------STALQ-------DIISKNIMLEQDIAGRQSSINAMNEK---VK 2176
T L+ DI+S ++ + + S N E+ ++
Sbjct: 2687 KGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLE 2746
Query: 2177 KFMETTDPSTASSLQAK---------MKDLSARFSEASHKHK---ETLAKMEEL--KTKV 2222
++ME+ D LQ + + L + SEA + +AK EL KT+
Sbjct: 2747 QWMESVDQKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTED 2806
Query: 2223 ELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLK 2282
E F++ +++ E KTQ + V + + ++ + +++ + + LHS +
Sbjct: 2807 ESFKDTAQE-----ELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKE 2861
Query: 2283 EISSHG-LPSDKALVLEKTNNLSK----------KFKEMEDTIKEKKEAVTS--CQEQLD 2329
E+ + D + +K + + + + +E E K+ T+ C+
Sbjct: 2862 ELHRWSDMSGDSSATQKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHT 2921
Query: 2330 AFQVLVKSLKSW----------IKETTKKVPIVQPSFGAE--DLGKSLEDTKKLQEKWSL 2377
Q L K W ++ ++ + + F + L ++LE L + W+
Sbjct: 2922 EMQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQ 2981
Query: 2378 KTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNG-EGTATNTEEFWANKG-LT 2435
+ L+ T + + G +L+ + TE+ + L
Sbjct: 2982 QL--------------TLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNELC 3027
Query: 2436 SIKKDMTDISHGYEDL-----GLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTA 2490
+D++ S L L L+ N + Q+ ++ QWL +N
Sbjct: 3028 RFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQWL--VNAKI 3085
Query: 2491 TKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWK 2550
T + P + V T +++ + F +E + +K+ + K ELL +A +
Sbjct: 3086 TTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSK-GELLSTLLTKEKAKGIQ 3144
Query: 2551 QMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSI 2610
+T W+ + ++ LE + F+ ++ WL + E MV
Sbjct: 3145 AKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLSKTEKMVHESSNRLY 3204
Query: 2611 DPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQK 2670
D ++Q++Q +L+E +PQ +L Q + S R +++ ++ +
Sbjct: 3205 DLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQLWEGQAASKSFR----HRVSQLSSQ 3260
Query: 2671 WDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQL 2730
+ +L+ ++ +D+ + + Q+ ++ L D ++D + L S ++ ++ +
Sbjct: 3261 YLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRT 3320
Query: 2731 ETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAEN 2790
+ + Q+++ Q+K+ E + E + + +QL+ + + +
Sbjct: 3321 LKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPT-IQQQLQSVKDMWASLLSAGIR 3379
Query: 2791 HVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTL 2850
L+ A + +Q R F W+D+ + N+S A+L +++ K ++ +
Sbjct: 3380 CKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHAELRDKTTMLGKAKLLNEEV 3439
Query: 2851 TAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEK 2910
+ S + E +G + +E QL+L ++ + ++ KE K ++ +
Sbjct: 3440 LSYSSLLETIEVKGAGM------TEHYVTQLELQDLQERYRAIQERAKEAVTKSEKLVRL 3493
Query: 2911 ALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEG-ENSIAKLKSLQKEMDQHFGMVELLN 2969
+Y+ ++ W+ + Q L++ A E ++ L+ LQ + ++ +
Sbjct: 3494 HQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVL 3553
Query: 2970 NTANSLL--SVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKE 3027
+T ++ + + + + +SL Q +L + N+ K + ++ ++
Sbjct: 3554 HTREDVIPSGIPQAEDRAL----ESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQ 3609
Query: 3028 SKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQ-----KSLQALKHQVDLAKRLAQDL 3082
L+ A+E++ S ++ SN+ +Q Q + + A + +V+ AQ++
Sbjct: 3610 VDEWLKTAEEKV----SPRTRRQSNRATKEIQLHQMKKWHEEVTAYRDEVEEVGARAQEI 3665
Query: 3083 VVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFA 3142
+ E S S + Q + + L QV E+ FLE ++Q + ++++ +
Sbjct: 3666 LDE---SHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSYSDWYG 3722
Query: 3143 EFDDELDSMAPVGRDAETLQ--KQKETIKAFLKKLEA----LMASNDNANKTCKMMLATE 3196
++A +T+ K+ +T++ LK +E L ++ + + K + E
Sbjct: 3723 STHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGE 3782
Query: 3197 ETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEE 3256
+++++ +Q +L + +E + +EF K K + + + +E
Sbjct: 3783 AER-----LRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQE 3837
Query: 3257 HEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGL 3316
ME QL+ +K Q+ + + + V G+ L++ T L
Sbjct: 3838 ILHVPEEPKMELYEKKAQLSKYKSLQQTVLSH-EPSVKSVREKGEALLELVQDVT----L 3892
Query: 3317 EHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTE-ELVANQKPP 3375
+ +D + + ++ L + L+ + + L+ + W++ LVA
Sbjct: 3893 KDKIDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQMSGRLVAPDLLE 3952
Query: 3376 SAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKI----ATTAEPADKVKILKQLSL 3431
++ + + Q+ K + + + + ++ +G+ + A + K + L
Sbjct: 3953 TSSLETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQG 4012
Query: 3432 LDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKL 3491
+ A+ + A+ + LE +TL+ WL+ ++ L ++
Sbjct: 4013 TKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEA 4072
Query: 3492 EEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEK 3551
+Q+ +AL++ +R D++ S D S +
Sbjct: 4073 IKQVKHFRALQEQ----------------------ARTYLDLLCSMCDLSNASVKTTAKD 4110
Query: 3552 SHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELR--- 3608
+ ++Q L A+ + E+ + +E+ L D + + ++ SEL
Sbjct: 4111 IQQTEQTIEQKLVQAQNLTQGWEEIKHLKSELWIYLQDA---DQQLQNMKRRHSELELNI 4167
Query: 3609 ----VLQEDILLRKQNVDQALLNGL-ELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTD 3663
V Q ++K QA +N + E + + T E ++ + ++ D+ + S +
Sbjct: 4168 AQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNN 4227
Query: 3664 VAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEA 3723
+ E+ LQ R H C + +V +E + E L +A + + LKK A
Sbjct: 4228 LCLQREEDLQRTRDYHD-----CMNVVEVFLEKFTTEWDNLARSDAESTAVHLEALKKLA 4282
Query: 3724 ---KNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAA 3780
+ K ++ L + ++E + +E +++ + +R+ + D I +K++ +
Sbjct: 4283 LALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQ-VSVT 4341
Query: 3781 ILRSQQFDQAADAEL-SWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDII 3839
L Q+ EL W E + + D L E+ + ++
Sbjct: 4342 NLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICSELEAKQMLL 4401
Query: 3840 DDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWET 3899
L+K ++M E+Q ++K L + + + + +R L +A S QF
Sbjct: 4402 KSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQFLMA 4461
Query: 3900 YEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLL 3959
+ + + + I L + + +Q + + + + ++ + + G +L+
Sbjct: 4462 VFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQNEVTGLWAQGRELM 4521
Query: 3960 -ELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERI 4018
E++ E + K ++Y + + R L++ + F + D+ L++
Sbjct: 4522 KEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKEDFDKACHWLKQA 4581
Query: 4019 VERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDIS 4078
++ E ++ Q+++ +N+ + + L TL++ G+ ++ D
Sbjct: 4582 DIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQTILPSLNEVDHSY- 4640
Query: 4079 AKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIV-TIKDTQ-DFIR 4136
+ +KL+ + + I L +++ K+ + + LA K + + L ++ + + F+R
Sbjct: 4641 ---LSEKLNALPRQFNVIVALAKDKFYKVQEAI-LARKEYASLIELTTQSLSELEAQFLR 4696
Query: 4137 DLEDPGIDPSVVK--QQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKS 4194
+ P D +V + Q+ I +E+ GL E +D +N E + G+P +P
Sbjct: 4697 MSKVP-TDLAVEEALSLQDGCRAILDEVAGLGEAVD-ELNQKKEGFRSTGQPWQP---DK 4751
Query: 4195 IDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDL 4254
+ L + + L + + R+ LE+ A +++ Q + + + + ++
Sbjct: 4752 MLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNE----- 4806
Query: 4255 ETVKQQIEELKQFKSEAYQQQ---IEMERLNHQAELL---LKKVTEESDKHTVQDPLMEL 4308
ET+ + E+LK + S A Q I ++R+ E L L + E +H +Q EL
Sbjct: 4807 ETLPAE-EKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGEL 4865
Query: 4309 KLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIE 4368
KL+ ++ E + + ++ ++ FQ + L WL + LS + + + I+
Sbjct: 4866 KLLTSAIGETVTECESRMVQSI----DFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQ 4921
Query: 4369 IELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKT 4428
E+ K + Q +V + + A++ + + +++L++ L L++ ++ E
Sbjct: 4922 EEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELDGDIQEAL 4981
Query: 4429 EQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHL-LASKPLGGLPETAKEQLNVHMEVC 4487
R+ L Q + ++ + WL D + L LA L E+A+E L HME
Sbjct: 4982 RTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLD--VESAEENLKSHME-- 5037
Query: 4488 AAFEAKEETYKSLMQKGQQMLARCPK----SAETNIDQDINNLKEKWESVETKLNERKTK 4543
F + E+ + S +++ ++A + + +++Q + +L+ + + + +
Sbjct: 5038 --FFSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQVDL 5095
Query: 4544 LEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQ----IDEHKVFANEV 4599
L+ ++ + ++ I + E+ L S SL+ + + + EHK + V
Sbjct: 5096 LQRCTAQWHDYQKAREEVIELMNDTEKKL---SEFSLLKTSSSHEAEEKLSEHKALVSVV 5152
Query: 4600 NSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKR 4659
NS E+I+ L++ + L+ + + +V RW ++ ++ + L+DA
Sbjct: 5153 NSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDE 5212
Query: 4660 AKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTN 4719
F+ K E +++ + L ++ T L H F L + S
Sbjct: 5213 WTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLR 5272
Query: 4720 RTGRSL---------KEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFS 4770
+ S+ E+ L + + D +++K T GK V+++ K E +
Sbjct: 5273 QQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKT-NGKLVKQELKDREMV--- 5328
Query: 4771 GQFTDALQALIDWL-----YRVEPQLAEDQPVHGDIDLVMNLIDNHK---------AFQK 4816
+ ++ W+ Y P + D + ++ +++ NH+ +K
Sbjct: 5329 ---ETQINSVKCWVQETKEYLGNPTIEIDAQLE-ELQILLTEATNHRQNIEKMAEEQKEK 5384
Query: 4817 ELGKRT-----SSVQ----ALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISK 4867
LG T S+Q AL R+ I+ + K QELS + + + +
Sbjct: 5385 YLGLYTILPSELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTI 5444
Query: 4868 QTRLEAALRQ-----------AEEFHSVVHALLEWLAEAEQTLRFHGVLPDD-EDALRTL 4915
T+L+A EE L+E A ++ L +G L + L
Sbjct: 5445 LTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKL 5504
Query: 4916 IDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQ 4975
+ H++ +++ E + ++LN+A + + + + + I WI + +AW
Sbjct: 5505 TELHQQTIRQAENRLSKLNQAASHLEE-----YNEMLELILKWIEKAKVLAHGTIAWNSA 5559
Query: 4976 HQQRLASALAGLIAKQEL-----LEALLAWLQWAETT-LTDKDKEVIPQ---EIEEVKAL 5026
Q R L + ++ LEA+ LQ+ + T+K + + + E EE++ +
Sbjct: 5560 SQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQM 5619
Query: 5027 IAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRK 5076
I + ++ + D+ K K+ A Q+ + + GR K
Sbjct: 5620 I---KIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLK 5666
Score = 293 bits (751), Expect = 2e-78
Identities = 845/4654 (18%), Positives = 1779/4654 (38%), Gaps = 620/4654 (13%)
Query: 612 EPNSLQTLKLMQIRKPLLKSSLLDQNL---TEEEINMKFVQDLLNWVDEMQVQL---DRT 665
+PN + LK Q P + +LL +L +E E ++ L+ D + L +R
Sbjct: 4364 QPNIAEALK--QSPPPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNERQ 4421
Query: 666 EWGSDLPSVESHL--------ENHKNVHRAIEEFESSLKEA--KISEIQMTAPLKLTYAE 715
L +SH+ + K +++A+ E L S+IQ K+ + E
Sbjct: 4422 VIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHER-KIMFRE 4480
Query: 716 KLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIA 775
+ L +K + T ++ + L T N EV W++
Sbjct: 4481 HICLLPDDVSKQVKTCKSAQASLKTYQN------------------EVTGLWAQGR---- 4518
Query: 776 RKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQ 835
ELM+E+ ++E++ E+ +L +Q+ + +LQ C
Sbjct: 4519 -------ELMKEVTEQEKS-----EVLGKL---------------QELQSVYDSVLQKCS 4551
Query: 836 CVEQHIKENTAYFEFFN-DAKEATDYLRNLKDAIQRKYSC-DRSSSIH----KLEDLVQE 889
Q +++N + F D +A +L+ + + + SS +H K ++++++
Sbjct: 4552 HRLQELEKNLVSRKHFKEDFDKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQ 4611
Query: 890 SMEEKEELLQYKSTIANLMGKAKTIIQ--LKPRNSDCPLKTSIPIKAICDYRQIEITIYK 947
S E + LL + T ++ + L + + P + ++ + D YK
Sbjct: 4612 SPEYENLLLTLQRTGQTILPSLNEVDHSYLSEKLNALPRQFNVIVALAKD------KFYK 4665
Query: 948 DDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWH 1007
E +LA + + ++ + + +E + + P DLA + L+L
Sbjct: 4666 VQEAILARKEYASLIELTTQSLSELEAQFLRMSKVP-----TDLA------VEEALSLQD 4714
Query: 1008 ESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQ 1067
+ V ++E+++ + ++ + P + +++ L R L+ E +
Sbjct: 4715 GCRAILDEVAGLGEAVDELNQKKEGFRSTGQPWQPDKMLHLVT-LYHR----LKRQTEQR 4769
Query: 1068 VFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLE-NCEDRL 1126
V D T +E Q + LKS + E+ + + L E + L + +D
Sbjct: 4770 VSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNEETLPAEEKLKMYHSLAGSLQDSG 4829
Query: 1127 IRQIRTPLERDDLHESVFRITEQ------EKLKKELERLKDDLGTITNKCEEFFSQAAAS 1180
I R + +DL + + + + + EL+ L +G +CE Q+
Sbjct: 4830 IVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQSI-- 4887
Query: 1181 SSVPTLRSELNVVLQNMNQVYSMSS--TYID--------KLKTVNLVLKNTQAAEALVKL 1230
++E++ L + +V + S Y+D +++ + + + Q++ ++
Sbjct: 4888 ----DFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNA 4943
Query: 1231 YETKLCEE-----EAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDE 1285
K E+ E + AD +E+ ++ L + ++ E AL I +
Sbjct: 4944 LSHKEKEKFTKAKELISAD---LEHSLAELSELDGDIQE------ALRTRQATLTEIYSQ 4994
Query: 1286 MFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDW 1345
+ Y+ DW ++ + L Q+ D+E ++LK + + + D +
Sbjct: 4995 CQRYYQVFQAANDWLEDAQELL---------QLAGNGLDVESAEENLKSHMEFFSTEDQF 5045
Query: 1346 IQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDY 1405
+E + P T L Q+ V+ +E++ +M
Sbjct: 5046 HSNLEELHSLVATLDPLIKPTGKEDLEQK---VASLELRSQRMSRDSG------------ 5090
Query: 1406 ELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSL 1465
A VD Q+ + Q + + +I+ D + + L T A + L
Sbjct: 5091 --------AQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKL 5142
Query: 1466 KRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKK 1525
E K+L EK L++ S + KT DA KA S + +
Sbjct: 5143 S----EHKALVSVVNSFHEKIVALEEKASQLEKTGNDASKA------TLSRSMTTVWQRW 5192
Query: 1526 EQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDV 1585
+L Q + L D+ T N+++K + + + + L S ++ +++ +
Sbjct: 5193 TRLRAVAQDQEKILEDAVDEWTGFN-NKVKKATEMIDQLQDKLPGSSAEKASKAELLTLL 5251
Query: 1586 KVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQK 1645
+ + V E +Q+ Q+ ++ Q M+ DG ++ L +
Sbjct: 5252 EYHDTFVLELEQQ-------------QSALGMLRQQTLSMLQDGAAPTP---GEEPPLMQ 5295
Query: 1646 DMQGSAQALAEVVKNTENFLKENGEKLSQE--DKALIEQKLNEAKIKCEQLNLKAEQSKK 1703
++ A+ + N + +K NG+ + QE D+ ++E ++N K ++
Sbjct: 5296 EIT----AMQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQETKEYLGNPTI 5351
Query: 1704 ELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQV--IEQN 1761
E+D QLEE + + + N++K +E K+ + I +
Sbjct: 5352 EIDA-----------------QLEELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILPS 5394
Query: 1762 GTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAV 1821
Q + + D++ + E + Q T + L++Q QK+ I+++ +A
Sbjct: 5395 ELSLQLAEVALDLKIRDQIQDKIKEVE---QSKATSQELSRQIQKLAKDLTTILTKLKA- 5450
Query: 1822 IIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMK-LTHSLQEELE 1880
++ V+ K Q + EE + + EL + L ++ + K L + + E
Sbjct: 5451 ----KTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTE 5506
Query: 1881 KFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKG--DLRYIT 1938
+ E+ L + Q +LE + + ++ +++ K + I+ LR
Sbjct: 5507 LHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQY 5566
Query: 1939 ISGNRVLEAAKSCSKRDGGKVD-------TSATHREVQR--KLDHATDRFRSLYSKCNVL 1989
I +LE +K + T + Q+ +L T+ R + +
Sbjct: 5567 ILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIK---IR 5623
Query: 1990 GNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQ--LEETKALQ 2047
NL+D + +E L A L+ +AT + +++ + RQ L E ++L+
Sbjct: 5624 LQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEMESLK 5683
Query: 2048 GQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQ 2107
++ + Q+ L+ +V+ A L A +Q E+ S+ + ++
Sbjct: 5684 PKVQAVQLCQSALRIPEDVV--ASLPLCHAALRLQ----------EEASRLQHTAIQQCN 5731
Query: 2108 ITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDI---ISKNIMLEQDIAGR 2164
I + + EM +E + +E P+ ++ +Q++ IS++ L Q I G
Sbjct: 5732 IMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGY 5791
Query: 2165 QSSINAMNEKVKKFMETTDPST-------ASSLQAKMKDLSARFSEASHKHKE----TLA 2213
Q I ++N K K +T L +DL H T
Sbjct: 5792 QEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAG 5851
Query: 2214 KMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVT---ELSQYMQESTSEFLEH 2270
+ L + V E+ E + + + + V D + +++ Y S
Sbjct: 5852 RCHTLLSPVTE-ESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTD 5910
Query: 2271 KKHLEVLHSLLKEISSHGL-PSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLD 2329
+ S +E GL PS A K +L + ++ +++ I EK+ + E+
Sbjct: 5911 AAKIHPSTSASQEFYEPGLEPSATA----KLGDLQRSWETLKNVISEKQRTLYEALERQQ 5966
Query: 2330 AFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSG 2389
+Q ++S+ + ++ K+ P G + E + E L+ EI ++ +S
Sbjct: 5967 KYQDSLQSISTKMEAIELKLS-ESPEPGRSPESQMAEHQALMDEILMLQD-EINELQSSL 6024
Query: 2390 ISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYE 2449
S PA+ +A + LT + + M+ I
Sbjct: 6025 AEELVSESCEADPAEQLALQST----------------------LTVLAERMSTIRMKAS 6062
Query: 2450 DLGLLLKDKI---AELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPA-PTDTEAV 2505
LL++K+ E + LQ+ + E+ + WL T P P D EA
Sbjct: 6063 GKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEA- 6121
Query: 2506 KTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENP--DTPEAPRWKQMLTEIDSKWQEL 2563
Q+ ++ E++Q V + EL LL E EA + L + EL
Sbjct: 6122 --QLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLEL 6179
Query: 2564 NQLTIDRQ-------QKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLN 2616
+ D+Q Q+ EES +LT Q+ Q +WL + + S+
Sbjct: 6180 QRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQ--EWLAQARTTWTQQRQSSL------ 6231
Query: 2617 TQRQQVQILLQEFATRKPQYEQLTAAGQGILSR---------PGEDPSLR----GIVKEQ 2663
QQ + L QE A +K + + G+ IL + GE P + G+ E+
Sbjct: 6232 ---QQQKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGEK 6288
Query: 2664 LAAVTQ---KWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDL-----DNKLSS 2715
+A Q KW+SL + S + + Q +++ Q Q L + LS + D
Sbjct: 6289 SSAEDQMRMKWESLHQEFSTKQKLL-QNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQD 6347
Query: 2716 SLAVSTHPDAMNQQLETAQKM-----KQEIQQEKKQ---IKVAQALCEDL-------SAL 2760
AV++ D +NQ E +Q I E+K + +D+ +AL
Sbjct: 6348 KSAVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATAL 6407
Query: 2761 VKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWL---- 2816
+ EE ++++ + K K++ ++ + + A + + + D L
Sbjct: 6408 LPEETETCLFNQEI--LAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRL 6465
Query: 2817 -----------DTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGE 2865
KE + L VL + + D+K L ++++E+ +AE
Sbjct: 6466 SLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYI--ILQKLANVFEQPVAEQI 6523
Query: 2866 NLL----------------LKTQGS----EKAALQLQLNTIKTNWDTFNKQVKERENKLK 2905
+ LK +G E+ ++Q +L+ ++ +D + R + L
Sbjct: 6524 EAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQ-ELSKLQDMYDELMMIIGSRRSGLN 6582
Query: 2906 ESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMV 2965
++L +Y+ ++ L ++ Q + + + ++ E I +L KE Q
Sbjct: 6583 QNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEE--IQQLLDKHKEYFQGLESH 6640
Query: 2966 ELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVS 3025
+L T + + KE T + L+ + V ++ H + LE + + + E
Sbjct: 6641 MILTETLFRKIISFAVQKE--TQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQ 6698
Query: 3026 KESKRQLQCAKEQLDIHDSLGSQAYSNKYL----TMLQTQQKSLQALKHQVDLAKRLAQD 3081
+E RQL+ + + S+G + L T+ Q + SL + ++ +
Sbjct: 6699 QELSRQLEVVESSIP---SVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKR 6755
Query: 3082 LVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQF 3141
L++ S SD+ Q+ + + + + ++ ++ LET L+ +Q+ ++
Sbjct: 6756 LLISIS----CSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWL 6811
Query: 3142 AEFDDELD----SMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEE 3197
D L+ V ++ E ++ F K+++A + + T +L ++
Sbjct: 6812 QSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKK 6871
Query: 3198 TSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGT-IKRLEEFY--SKLKEFSILLQKA 3254
D ++ +L + Q LL A +E++ + +L + S++ + L++
Sbjct: 6872 V--DTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENV 6929
Query: 3255 EEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQ 3314
+ +E + + I++ L +K F+ + + KQ V+++ Q ++Q +++ ++
Sbjct: 6930 IQKDEDNIKNSIGYKAIHEYLQKYKGFKID----INCKQLTVDFVNQSVLQISSQDVESK 6985
Query: 3315 GLE-----HDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELV 3369
+ L +N W+ L V ++ L+ L +++ ++ L +W +T+E
Sbjct: 6986 RSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWF-ETQEKR 7044
Query: 3370 ANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQL 3429
Q+ + V+ +++ + L+ L+ ++ VE I++ G + + ++ L
Sbjct: 7045 LKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMSTL 7104
Query: 3430 SLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQAS 3489
L W L + L+ + + +N +L L +
Sbjct: 7105 RELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLE 7164
Query: 3490 KLEEQIAQHKALEDDIINHNKHLHQAVSI-GQSLKVLSSREDKDMVQSKLDFSQVW---Y 3545
++ Q+ + L+DD+ + L + SI Q LK + + + + + W
Sbjct: 7165 AVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLL 7224
Query: 3546 IEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQS 3605
EI E+ S LLQ + + S + Q+ T L K +
Sbjct: 7225 EEIAEQLQSSKALLQL--------------WQRYKDYSKQCASTVQQQEDRTNELLKAAT 7270
Query: 3606 ELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVA 3665
+ +++ Q+ + LL GL +K D + + + E +K + + A
Sbjct: 7271 NKDIADDEVATWIQDCND-LLKGLGTVK----DSLFFLHELGEQLKQQ------VDASAA 7319
Query: 3666 KTLEQ-ALQLARRLHSTHEELCTWLDKVEVELLSYET----------------QVLKGEE 3708
++ L L++ L + + LC ++ +L YET ++L+G++
Sbjct: 7320 SAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQD 7379
Query: 3709 ASQA------QMRPKELKKEAKNNKAL---LDSLNEVSSALLELVPWRAREGLEKMVAED 3759
S + Q R +ELK + ++ LD LNE+ L P +E K +
Sbjct: 7380 PSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRL----PLNDKE--IKRMQNL 7433
Query: 3760 NERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTS 3819
N + L+S T++ ++ + +L+ Q F + + + ++ +TE+KL +I
Sbjct: 7434 NRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAV--EISGNYQHLL 7491
Query: 3820 AQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQIN 3879
Q + + F E+ + I+ ++ G +++ +++ KL + + + +
Sbjct: 7492 EQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRA 7551
Query: 3880 SERYLQLERAQSLVNQFWETYEELWPWLTETQSI----ISQLPAPALEYETLRQQQEEHR 3935
+R ++ ++ E E+L WL E + + +P P + TL + +
Sbjct: 7552 QQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKE 7611
Query: 3936 QLRELIAEHKPHIDKMNKTGPQLLELSPG-------EGFSIQEKYVAADTLYSQIKEDVK 3988
++ + + +I + LL G E IQEK+ +A +++E K
Sbjct: 7612 KV--FLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASM---RLEEQKK 7666
Query: 3989 KRAVALDEAISQSTQFHDKIDQILESLERIVERLRQP-PSISAEVEKIKEQISENKNVSV 4047
K A L + D ++++ +++ + L + AE + KE + + +
Sbjct: 7667 KLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTD 7726
Query: 4048 DMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKL 4107
D+ +L L +TL A D I + ++++ + WE + + R ++
Sbjct: 7727 DLTQLSLLKDTLS-------AYISADDISI----LNERVELLQRQWEELCHQLSLRRQQI 7775
Query: 4108 LDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQE 4167
+ + F + L + + + D I+ + K +++ +EEI QE
Sbjct: 7776 GERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLKKD----YQEEIAIAQE 7831
Query: 4168 ELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQ 4227
+ +G L A E ++ + ++N W L R+ KL+E + A Q
Sbjct: 7832 NKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLD 7891
Query: 4228 DGLQAVFDWVDIAGGKLASMSPIGTDL---ETVKQQIEELKQFKSEAYQQQIEMERLNHQ 4284
+ ++ W+ +LA PI D E +++++ E ++ + + + + + +
Sbjct: 7892 KNMSSLRTWLAHIESELAK--PIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNL 7949
Query: 4285 AELLLKKV---TEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALD 4341
E+LL +++ ++Q L W ++ + R+ K+E +F
Sbjct: 7950 CEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYS 8009
Query: 4342 ELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIES 4401
WL +E + G + EL K Q V + +E +NK L
Sbjct: 8010 RFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARE 8069
Query: 4402 SAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTER 4461
+ + A +L+ + NQRW N+ ++ ++L + Q + F + + WLT+ +
Sbjct: 8070 NRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDL 8129
Query: 4462 HLLASKPLGGLPETAK-EQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNID 4520
L + AK +QL + + K E ++ +G+Q++ + I+
Sbjct: 8130 QLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIE---QIIAQGEQLIEKSEPLDAAIIE 8186
Query: 4521 QDINNLKEKWESV-------------------ETKLNERKTKLEEALNLA-MEFHNSLQD 4560
++++ L+ + V E L++R+ +LE++ L+ + +H+ D
Sbjct: 8187 EELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSAD 8246
Query: 4561 FINWLTQAEQTLNVASRPSL-----------ILDTVLFQIDEHKVFANEVNSHREQIIEL 4609
+ Q L+++ L +D++ + D + ++ S + +
Sbjct: 8247 SL-LSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPS 8305
Query: 4610 -DKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWS 4668
D+ G K F + V L + S E +++L G++LDD+R + +Q
Sbjct: 8306 EDEEGQDDKDFYLRGAVGLSGD-----HSALESQIRQL---GKALDDSRFQIQQ------ 8351
Query: 4669 KLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEK 4728
E + S+ EL+ + +K + K LG S D+ R LKE+
Sbjct: 8352 --TENIIRSKTPTGPELDTS------------YKGYMKLLGECSSSIDSVKRLEHKLKEE 8397
Query: 4729 TSLADDNLKL---DDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLY 4785
+ L + + + D+W+ + +++ ++ ++++ L QF L ++ WL
Sbjct: 8398 EESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLG 8457
Query: 4786 RVEPQLAEDQPVH--GDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDS 4843
E +L + Q + DI + I K QK + R + + ++ + E + +S
Sbjct: 8458 DTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKES 8517
Query: 4844 SWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHG 4903
++ ++ +++ RW+ VC+L + L+ AL Q + FH + H LL L ++ R +
Sbjct: 8518 RDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDR--RKNE 8575
Query: 4904 VLPDDEDA-LRTLIDQHKEFMK---KLEEKRAELNKATTMGDTVLAICHPDSITTIKHWI 4959
++P D + L D HK+ M+ +L E + + M +L K +
Sbjct: 8576 IVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKV 8635
Query: 4960 TIIRARFEEVLAWAKQHQQRLASALAGLIAKQEL 4993
+I R + +L +H + L L ++Q+L
Sbjct: 8636 HVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQDL 8669
Score = 266 bits (681), Expect = 3e-70
Identities = 776/4275 (18%), Positives = 1638/4275 (38%), Gaps = 517/4275 (12%)
Query: 1021 YLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQES-----QVFSGSDIT 1075
+L++E+ +I +S+ + +KT + + L ++ + E+ ++ + S V S D
Sbjct: 2151 HLLSELKKIHSSDFSLVKTDMESTVDKWL-DVSEKLEENMDRLRVSLSIWDDVLSTRD-- 2207
Query: 1076 QLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDR------LIRQ 1129
++E N C E + + + + E + + SEV+N LRLE + L +
Sbjct: 2208 EIEGWSNNCVPQMAENISNLDNHLRAEELLKEFESEVKNKALRLEELHSKVNDLKELTKN 2267
Query: 1130 IRTP-----LERDDLH--ESVFRITEQEK--------LKKELERLKDDLGTITNKCEEFF 1174
+ TP +E D + E ITE K ++E+ +D+ T K EE
Sbjct: 2268 LETPPDLQFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESL 2327
Query: 1175 SQAAASSSVPTLRSELNVVLQNMNQVYSMSST-------------------------YID 1209
A + + L+ ++ + +Q ++SST I
Sbjct: 2328 MNCAQNETCEALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIK 2387
Query: 1210 KLKTVNLVLKNTQAA--EALVKLYETKLCEEE-----AVIADKNNIENLISTLKQWRSEV 1262
K + V+ + TQA+ E+L K + + E + A A K + + K +++
Sbjct: 2388 KHEAVSQLCSKTQASLQESLEKHFSESMQEFQEWFLGAKAAAKESSDR-TGDSKVLEAKL 2446
Query: 1263 DEKRQVFHALEDELQKAKAISDEMFKTYKERDLDF-DWHKEKADQLVERWQNVHVQIDNR 1321
+ + + ++ D K A++ E Y +E+ + E +Q Q
Sbjct: 2447 HDLQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKD 2506
Query: 1322 LRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQ---QKMLV 1378
+ L+ L + D + L+ WI ++E +R EN E+ + + + N+ +M +
Sbjct: 2507 KQALQDCASELGSFEDQHRKLNLWIHEME--ERFNTENLGESKQHIPEKKNEVHKVEMFL 2564
Query: 1379 SEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQ 1438
E+ + +D+ + + S + ++ S Q + S + +Q
Sbjct: 2565 GELLAARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQVALQ 2624
Query: 1439 EFMDLRTRYTAL---VTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAK---ELQKW 1492
E L ++ V + + A +L + EK L + + + K + +L
Sbjct: 2625 EHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMA 2684
Query: 1493 VSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSE-------ALQTIQLFLAKHGDK 1545
+ + L+ + K G Q++ ++ T KE ++ A T++ +++ D
Sbjct: 2685 IGKGEQALRSSNKEG------QRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDY 2738
Query: 1546 MTDEERNELEKQVKTLQE--SYNLLFSESLKQ-------LQE--SQTSGDVKVEEKIVAE 1594
+ E +N+LE+ ++++ + + L LK+ LQ S+ + +++A+
Sbjct: 2739 V--ERKNQLEQWMESVDQKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAK 2796
Query: 1595 RQQEY-------------KEKLQGICDLLTQTENRLIGHQEA----FMIGDGTVELKKY- 1636
++ Y +E D++T + ++ +E M D E +
Sbjct: 2797 SRELYEKTEDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWL 2856
Query: 1637 QSKQEELQK--DMQGSAQALAEVVKNTENFLKE---NGEKLSQEDKALIEQKLNEAKIKC 1691
S +EEL + DM G + A + + + + +LS+ + E K N C
Sbjct: 2857 HSAKEELHRWSDMSGDSSATQKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGC 2916
Query: 1692 EQLNLKAE--------------QSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLL 1737
E ++ + + Q++ L+ +V+ E E V QLE++ + LL
Sbjct: 2917 ELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALL 2976
Query: 1738 -DWL--------SNVDKDSERAGTKHKQVIEQ-NGTHFQEGDGKSAIGE----------- 1776
W N D++ K +++++ + D KS + E
Sbjct: 2977 KTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTY 3036
Query: 1777 EDEVNG-----NLLETDVDGQVGTTQENLNQQYQKVKAQHEK-----IISQHQAVIIATQ 1826
+V+G N L ++ L Q+++K ++ I+ + I
Sbjct: 3037 SGKVSGLIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQN 3096
Query: 1827 SAQV--LLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDA 1884
++V L+K ++LS E + + NM K + L EK +Q ++
Sbjct: 3097 ISEVSTSLQKIQEFLSESENGQHKLNMMLSKGELLSTLLTKEK----AKGIQAKVTAAKE 3152
Query: 1885 DYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRV 1944
D+ F L Q E LENL+ D ++ S +E ++ + Y + R
Sbjct: 3153 DWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLSKTEKMVHESSNRLYDLPAKRRE 3212
Query: 1945 LEAAKS------CSKRDGGKVDTSATHR-EVQRKLDHATDRFRSLYSKCNVLGNNLKDLV 1997
+ +S C + ++ A E Q R L S+ L N K+ V
Sbjct: 3213 QQKLQSVLEEIHCYEPQLNRLKEKAQQLWEGQAASKSFRHRVSQLSSQYLALSNLTKEKV 3272
Query: 1998 DKYQHYEDASCGLLAGLQACE--ATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQV 2055
+ G++ + T + H+ + + T L+ +S +Q
Sbjct: 3273 SRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEALLSVKQE 3332
Query: 2056 AVEKLK----KTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLT 2111
++K + VL + +P IQ+ L + + L + +L+ L+
Sbjct: 3333 KEIQMKMIVTRGESVLQNTSPEGIPT---IQQQLQSVKDMWASLLSAGIRCKSQLEGALS 3389
Query: 2112 RSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAM 2171
+ S QDG+ + WM ++E++L E + ++ K +L +++ S + +
Sbjct: 3390 KWTSYQDGVRQFSGWMDSMEANLNESERQHAELRDKTTMLGKAKLLNEEVLSYSSLLETI 3449
Query: 2172 NEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEK 2231
K E Q +++DL R+ + KE + K E+L + ++ +
Sbjct: 3450 EVKGAGMTE------HYVTQLELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRDLKA 3503
Query: 2232 LQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLL---KEISSHG 2288
+ +L + + L + V D +++ + + +L+S+L +++ G
Sbjct: 3504 FEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVLHTREDVIPSG 3563
Query: 2289 LP--SDKAL-----------------------VLEKTNNLSKKFKEMEDTIKEKKEAV-- 2321
+P D+AL V+ K + +KF+++++ +K +E V
Sbjct: 3564 IPQAEDRALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVSP 3623
Query: 2322 -TSCQEQLDAFQVLVKSLKSWIKETT-----------KKVPIVQPSFGAEDLG-KSLEDT 2368
T Q ++ + +K W +E T + I+ S +G ++ + T
Sbjct: 3624 RTRRQSNRATKEIQLHQMKKWHEEVTAYRDEVEEVGARAQEILDESHVNSRMGCQATQLT 3683
Query: 2369 KKLQ-------EKWSLKTPEIQKVNNSGISLCNL----------ISAVTTPAKAIAAVKS 2411
+ Q E+ EIQ + S SL + V T + V
Sbjct: 3684 SRYQALLLQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDKVDTVMM 3743
Query: 2412 G---------------------GAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYED 2450
G A GE EE A + ++K++ D ++
Sbjct: 3744 GKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGEAER----LRKEIHDHMEQLKE 3799
Query: 2451 LGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAV--KTQ 2508
L ++ + L L ++ ++ A+ QW+ + + P E K Q
Sbjct: 3800 LTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEIL----HVPEEPKMELYEKKAQ 3855
Query: 2509 VEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTI 2568
+ + KS + + + V+ +++K LLE D K + ++ S +Q+L +
Sbjct: 3856 LSKYKSLQQTVLSHEPSVKSVREKGEALLELVQDV----TLKDKIDQLQSDYQDLCSIGK 3911
Query: 2569 DRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQE 2628
+ LE + + + ++++WL++ + + P++L T ++ + Q+
Sbjct: 3912 EHVFSLEAKVKDHEDYNSELQEVEKWLLQ-------MSGRLVAPDLLET--SSLETITQQ 3962
Query: 2629 FATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQA 2688
A K E++ + + + +L G + L A ++ ++ L D A
Sbjct: 3963 LAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQ--NVHAHLQGTKDSY-SA 4019
Query: 2689 IVKSTQ--YQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQ 2746
I + Q YQSL L +S D +S A+ LE + + + KQ
Sbjct: 4020 ICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLS----AVQPDLEPSPQPPLSRAEAIKQ 4075
Query: 2747 IKVAQALCEDLSALVKEEYLKAELSR-QLEGILKSFKDVEQKAENHVQHLQSACASSHQF 2805
+K +AL E + +LS ++ K + EQ E + Q+ +
Sbjct: 4076 VKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQKLVQAQNLTQGWEEI 4135
Query: 2806 QQMSRDFQAWL-DTKKEEQN-KSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAE 2863
+ + + +L D ++ QN K +L++ ++++ KDF K L ++ TI E
Sbjct: 4136 KHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQASV-NTIIE 4194
Query: 2864 GENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWP 2923
N L K E++ ++N + W +Q + +E L++ Y + + +
Sbjct: 4195 KVNKLTK---KEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVEV 4251
Query: 2924 WIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQK---EMDQHFGMVELLNNTANSLLSVCE 2980
+++K + L ++ E++ L++L+K + + +E L + ++
Sbjct: 4252 FLEKFTTEWDN----LARSDAESTAVHLEALKKLALALQERKYAIEDLKDQKQKMIEHLN 4307
Query: 2981 I-DKEVVTDENKSLIQK----VDMVTEQLHSKKFCLENMT---QKFKEFQEVSKESKRQL 3032
+ DKE+V ++ L Q+ D++ ++ LE + +F+E E ++E + +
Sbjct: 4308 LDDKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNI 4367
Query: 3033 QCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDL------VVEA 3086
A +Q D +Q +L + + LK + A R+ DL V++
Sbjct: 4368 AEALKQSPPPDM--AQNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQK 4425
Query: 3087 SDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDD 3146
+ S S V + + Q L++ + EK FL Q Q R++ F E
Sbjct: 4426 ALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKI--MFREHIC 4483
Query: 3147 ELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIK 3206
L V + +T + + ++K + ++ L A K TE+ +++G
Sbjct: 4484 LLPD--DVSKQVKTCKSAQASLKTYQNEVTGLWAQGRELMKE-----VTEQEKSEVLG-- 4534
Query: 3207 RDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGM 3266
L+ L + +L + R +++E + + F + L++A+ + +
Sbjct: 4535 -KLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKEDFDKACHWLKQADIVTFPEINLMN 4593
Query: 3267 ETETINQQLNMFK--VFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVN 3324
E+ ++ QL ++ + Q E E L Q GQ ++ S L L+ +
Sbjct: 4594 ESSELHTQLAKYQNILEQSPEYENLLLTLQRT---GQTILPS-LNEVDHSYLSEKLNALP 4649
Query: 3325 ARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKA 3384
++ + + ++QEA+L + +E + + E + V +A
Sbjct: 4650 RQFNVIVALAKDKFYKVQEAILARKEYASLIELTTQSLSELEAQFLRMSKVPTDLAVEEA 4709
Query: 3385 QIQEQKLLQRLLDD---RKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLN 3441
+ Q + +LD+ V+ + ++ E +T +P K+L ++L + L
Sbjct: 4710 -LSLQDGCRAILDEVAGLGEAVDELNQKKEGFRSTGQPWQPDKMLHLVTL----YHRLKR 4764
Query: 3442 KAETRNRQLEGISVVAQQFHETLEPLNEWLTTI--EKRLVNCEPIGTQASKLEEQIAQHK 3499
+ E R LE + Q+ + + L L ++ E+ VN E + + KL+ +
Sbjct: 4765 QTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNEETLPAE-EKLKMYHSLAG 4823
Query: 3500 ALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELL 3559
+L+D I + + L L+ + + +QS W E++ + + E +
Sbjct: 4824 SLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQS-------WQGELKLLTSAIGETV 4876
Query: 3560 QQALCNAKI-----FGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDI 3614
+ C +++ F + ++WL V +LS D + + + ++ ++++ QE++
Sbjct: 4877 TE--CESRMVQSIDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEV 4934
Query: 3615 --LLRKQNVDQALLNGLELLKQTTGDEVLI--IQDKLEAIKARYKDITKLSTDVAKTLEQ 3670
LR N L+ E K T E++ ++ L + DI + TL +
Sbjct: 4935 QSSLRIMNA----LSHKEKEKFTKAKELISADLEHSLAELSELDGDIQEALRTRQATLTE 4990
Query: 3671 ALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALL 3730
+R + + WL+ + ELL L E A + E + L
Sbjct: 4991 IYSQCQRYYQVFQAANDWLEDAQ-ELLQLAGNGLDVESAEENLKSHMEFFSTEDQFHSNL 5049
Query: 3731 DSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQA 3790
+ L+ + + L L+ +E LE+ VA R + +S +V+ + + + +A
Sbjct: 5050 EELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQKA 5109
Query: 3791 ADAELSWITETEKKLMSLGDIRLEQD-QTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKI 3849
+ + + +TEKKL ++ + +L K + + I L + ++
Sbjct: 5110 REEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQL 5169
Query: 3850 MTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTE 3909
++ K ++ + + V + + + + ++ LE A F ++ + +
Sbjct: 5170 EKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMIDQ 5229
Query: 3910 TQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLE----LSPGE 3965
Q + A L E H + + + + + + +L+ +PGE
Sbjct: 5230 LQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGE 5289
Query: 3966 GFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQP 4025
+ ++ A ++E VK + + + +I+ + ++ E L P
Sbjct: 5290 EPPLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQETKEYLGNP 5349
Query: 4026 P-SISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQD 4084
I A++E+++ ++E N ++EK+ +++ E+ + ++S + +
Sbjct: 5350 TIEIDAQLEELQILLTEATNHRQNIEKM------AEEQKEKYLGLYTILPSELSLQLAEV 5403
Query: 4085 KLDQMVFIWENIHTLVEEREAKLLDVMELA---EKFWCDHMSLIVTIKDTQDFIRDLEDP 4141
LD + I + I ++E E EL+ +K D +++ +K D
Sbjct: 5404 ALD--LKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTD-------- 5453
Query: 4142 GIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSA 4201
V Q + + + EE+DG +L + + + G+ KP+ KK I +L
Sbjct: 5454 -----NVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGKPLAKK-IGKLTEL 5507
Query: 4202 WDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVD----IAGGKLA--SMSPIGTDLE 4255
+ ++R+ KL +A +Y + L+ + W++ +A G +A S S +
Sbjct: 5508 HQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYI 5567
Query: 4256 TVKQQIEELKQFKS--EAYQQQIE-------MERLNHQAELLLKKVTE-----ESDKHTV 4301
+ +EE K+ S EA ++++ E+++ Q L ++ E + +
Sbjct: 5568 LHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNL 5627
Query: 4302 QDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVG 4361
QD ++K E + Q LE A L + L L+H + LLSE + +
Sbjct: 5628 QDAAKDMK----KFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEMESL- 5682
Query: 4362 GDPKAIEIELAKHHV-LQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQR 4420
PK ++L + + + DV+A A + EEAS LQ+
Sbjct: 5683 -KPKVQAVQLCQSALRIPEDVVASLPLCHAALR---------LQEEASRLQHTAIQQCNI 5732
Query: 4421 WQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLG-GLPETAKEQ 4479
Q + + EQ +Q++ + +G H EIED KP+ + + Q
Sbjct: 5733 MQAAVVQYEQYEQEMKHLQQLIEGAHREIED---------------KPVATSNIQELQAQ 5777
Query: 4480 LNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNE 4539
++ H E+ + +E SL K + + + + ++ L E E ++ +L
Sbjct: 5778 ISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLP 5837
Query: 4540 RKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVAS------RPSLILDTVLFQIDEHK 4593
+ + + ++L + + E T + S PS + +T +++
Sbjct: 5838 TPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPSPVANTDA-SVNQDI 5896
Query: 4594 VFANEVNSHREQ--IIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGR 4651
+ +++ R Q ++ + + + F + L +Q WE + + E+ R
Sbjct: 5897 AYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQR 5956
Query: 4652 SLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKE-FQKSLGA 4710
+L +A +R +++ ++ + +E E L E P+ +Q+A+H+ + L
Sbjct: 5957 TLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPE---SQMAEHQALMDEILML 6013
Query: 4711 KHSVYDTTNRTGRSLKEKTSLAD--DNLKLDDMLSELRDKWDTICGKSVERQNKLEEAL- 4767
+ + + + L ++ AD + L L L+ L ++ TI K+ ++ LEE L
Sbjct: 6014 QDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLN 6073
Query: 4768 --LFSGQFTDALQ-------ALIDWLYRVEPQL-AEDQPVHGDIDLVMNLIDNHKAFQKE 4817
L + ALQ L WL + L P +D+ L+D +
Sbjct: 6074 DQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEI 6133
Query: 4818 LGKRTSSVQALKRSARELIEG---SRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAA 4874
K + + + L+EG ++D++ + +++ L + KQ ++
Sbjct: 6134 EQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGT 6193
Query: 4875 LRQAEEFHSVVHA-----LLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEK 4929
++ EE + A + EWLA+A T ++ + Q KE ++L E+
Sbjct: 6194 AQEKEESDVDLTATQSPGVQEWLAQARTTW---------TQQRQSSLQQQKELEQELAEQ 6244
Query: 4930 RAELNKATTMGDTVL 4944
++ L + G+ +L
Sbjct: 6245 KSLLRSVASRGEEIL 6259
Score = 227 bits (579), Expect = 2e-58
Identities = 847/4800 (17%), Positives = 1742/4800 (36%), Gaps = 846/4800 (17%)
Query: 631 SSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSD-LPSVE---SHLENHKNVHR 686
S L++N+ +++ D+L+ DE++ W ++ +P + S+L+NH
Sbjct: 2182 SEKLEENMDRLRVSLSIWDDVLSTRDEIE------GWSNNCVPQMAENISNLDNHLRAEE 2235
Query: 687 AIEEFESSLKE---------AKISEIQ-----MTAPLKLTYAEKLHRLESQYAKLLNTSR 732
++EFES +K +K+++++ + P L + E + ++AK +
Sbjct: 2236 LLKEFESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEIT--- 2292
Query: 733 NQERHLDTLHNFVSRATNELIWLNE-----KEEEEVAYDWSERNTNIARKKDYHAELMRE 787
E TL +F +++T ++N+ + EE + ++ T A KK ++ +E
Sbjct: 2293 --EVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCAQNETCEALKKV--KDIQKE 2348
Query: 788 LDQKEENIKSVQEIAEQLLLENHPARL---------TIEAYRAAMQTQWSWILQLCQCVE 838
L ++ NI S QE L + H A L I+ + A Q L + +E
Sbjct: 2349 LQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLE 2408
Query: 839 QHIKENTAYF-EFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEEL 897
+H E+ F E+F AK A K S DR+ LE + + + +
Sbjct: 2409 KHFSESMQEFQEWFLGAKAAA------------KESSDRTGDSKVLEAKLHDLQNILDSV 2456
Query: 898 LQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNS 957
+S + + + +T+ + +I ++ AN
Sbjct: 2457 SDGQSKLDAVTQEGQTLYA---------------------HLSKQIVSSIQEQITKANEE 2495
Query: 958 HRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLW-HESHINMKSV 1016
+A K C ++ E Q++ L LW HE
Sbjct: 2496 FQAFLK-------------QCLKDKQALQDCASELGSFEDQHRK-LNLWIHEME------ 2535
Query: 1017 VSWHYLINEIDRIRASNVASIKTMLPGEHQQV------LSNLQSRFEDFLEDSQESQVFS 1070
+R N+ K +P + +V L L + E + SQ Q+ S
Sbjct: 2536 ----------ERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLS 2585
Query: 1071 GSDITQLEKEVNVCKQY---YQELLKSAEREEQEESV----YNLYISEVRNIRLRLENCE 1123
+ +E +C Q +Q LL+ + + + V + ++++ ++ +
Sbjct: 2586 -EEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAIQ 2644
Query: 1124 DRLIRQIRTPLERDDLHESVFRITEQEKLKKELE-RLKDDLGTITNKCEEFFSQAAASSS 1182
DRL T +D L + + +I + +K E E +L +G + A SS
Sbjct: 2645 DRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAIGK---------GEQALRSS 2695
Query: 1183 VPTLRSELNVVLQNMNQVYS-MSSTYIDKLKTVNLVLKN----TQAAEALVKLYETKLCE 1237
+ + L+ + +V++ + S+ + T+ V+ + L + E+ +
Sbjct: 2696 NKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQK 2755
Query: 1238 EEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAI----SDEMFKTYKER 1293
E + + ++ L +S + E AL + K++ + DE FK +
Sbjct: 2756 IEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQ- 2814
Query: 1294 DLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQ 1353
++L ++ ++ ++R +E I K Y D H DW+ +
Sbjct: 2815 -----------EELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEEL 2863
Query: 1354 RKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQ--YSATVKDYELQTMT 1411
+ + ++S T +L++ K L+ E+ S++ + A + + T EL
Sbjct: 2864 HRWSDMSGDSSAT-QKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTE 2922
Query: 1412 YRAM-------VDSQQKSPVKRRRMQSSADLIIQEFM-------DLRTRYTALVTLMTQY 1457
+A+ DS ++ + S L QEF +++AL+ Q
Sbjct: 2923 MQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQ 2982
Query: 1458 IKFAG-------------------DSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISK 1498
+ D+L++ E + L+ + E +++L + +S
Sbjct: 2983 LTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSG 3042
Query: 1499 TLKDAE----KAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGD--KMTDEERN 1552
+K+ +A K +K++I + + L ++ AK D + E
Sbjct: 3043 LIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVST 3102
Query: 1553 ELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQ 1612
L+K + L ES N +L + G++ KEK +GI +T
Sbjct: 3103 SLQKIQEFLSESEN-----GQHKLNMMLSKGELL--------STLLTKEKAKGIQAKVTA 3149
Query: 1613 TENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKL 1672
+ + +E K Q KD + SA+ + + + TE + E+ +L
Sbjct: 3150 AKEDWKNFHSNLHQKESALENLKIQ------MKDFEVSAEPIQDWLSKTEKMVHESSNRL 3203
Query: 1673 -----SQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLE 1727
+ ++ ++ L E QLN E++ ++ E AA K
Sbjct: 3204 YDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKA------------QQLWEGQAASKSFR 3251
Query: 1728 ESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLET 1787
+++ + LSN+ K E+ + V E N F G + D ++
Sbjct: 3252 HRVSQLSSQYLALSNLTK--EKVSRLDRIVAEHN--QFSLGIKELQDWMTDAIH------ 3301
Query: 1788 DVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAV---IIATQSAQVLLEKQGQYLSPEEK 1844
+D T + + +K + + Q + + +I T+ VL Q SPE
Sbjct: 3302 MLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVL-----QNTSPEGI 3356
Query: 1845 EKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLE 1904
+Q+ ++ +K + + L+ + + + +F W+ E L E
Sbjct: 3357 PTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESE 3416
Query: 1905 AGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSAT 1964
++ T L + K +E+V+S+ L I + G + E
Sbjct: 3417 RQHAELRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTE------------------ 3458
Query: 1965 HREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKH 2024
H Q +L +R+R++ + + LV +Q Y+ L+A E +
Sbjct: 3459 HYVTQLELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQ-------RDLKAFEVWLGQE 3511
Query: 2025 LSE-----PIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKN 2079
+ + D + L + + LQ + Q + + T E D S +P
Sbjct: 3512 QEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVLHTRE---DVIPSGIPQAE 3568
Query: 2080 DIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQ 2139
D + L+ + ++ ++E + + + ++ ++ +W+ E + + +
Sbjct: 3569 D--RALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVSPRTR 3626
Query: 2140 VPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSA 2199
N + + + +++ + + + + ++ ++ + ++ QA L++
Sbjct: 3627 RQSNRATKEIQLHQMKKWHEEVTAYRDEVEEVGARAQEILDESHVNSRMGCQA--TQLTS 3684
Query: 2200 RFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQY 2259
R+ + L +++ L+ +++ E L ++ + + ++
Sbjct: 3685 RYQALL---LQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDKVDTV 3741
Query: 2260 MQESTSEFLE-HKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSK-------KFKEME 2311
M + LE K +E HSLLK G + K L + L K + KE+
Sbjct: 3742 MMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELT 3801
Query: 2312 DTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPI-VQPSFGAEDLGKSLEDTKK 2370
T++++ + F K+L WI E + + + +P + L K
Sbjct: 3802 STVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKS 3861
Query: 2371 LQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWA 2430
LQ+ P ++ V G +L L+ VT
Sbjct: 3862 LQQTVLSHEPSVKSVREKGEALLELVQDVT------------------------------ 3891
Query: 2431 NKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTA 2490
+K + + Y+DL + K+ + L K+ + E + +WL +M+
Sbjct: 3892 ------LKDKIDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQMSGRL 3945
Query: 2491 TKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWK 2550
P +T +++T +Q K
Sbjct: 3946 V----APDLLETSSLETITQQ----------------------------------LAHHK 3967
Query: 2551 QMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSI 2610
M+ EI LN L + + + +++L +A+LKQ + + G
Sbjct: 3968 AMMEEIAGFEDRLNNLQMKGDTLIGQCADHL------QAKLKQ-----NVHAHLQGTKDS 4016
Query: 2611 DPNMLNTQRQQVQIL---LQEFATRKPQYEQLTA---AGQGILSRPGEDPSLRGIVKEQL 2664
+ +T ++ Q L LQ+ +R+ +Q A A Q L + P R +Q+
Sbjct: 4017 YSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQV 4076
Query: 2665 ---AAVTQKWDSLTGQLSDRCDWIDQAIVKST--QYQSLLRSLSDKLSDLDNKLSSSLAV 2719
A+ ++ + L CD + A VK+T Q +++ KL N +
Sbjct: 4077 KHFRALQEQARTYLDLLCSMCD-LSNASVKTTAKDIQQTEQTIEQKLVQAQNLTQGWEEI 4135
Query: 2720 STHPDAMNQQLETAQKMKQEIQQEKKQIK--VAQALCEDLSALVKE-EYLKAELSRQLEG 2776
+ L+ A + Q +++ +++ +AQ + + VK+ + +A ++ +E
Sbjct: 4136 KHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEK 4195
Query: 2777 ILKSFKDVEQKAENHVQHL-----------QSACASSHQFQQMSRDFQAWLDTKK---EE 2822
+ K K E + HL + C + Q +RD+ ++ + E+
Sbjct: 4196 VNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFLEK 4255
Query: 2823 QNKSHPISAKLDVLESLI--KDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQ 2880
A+ D + + + K + L + + E + + ++ +K ++
Sbjct: 4256 FTTEWDNLARSDAESTAVHLEALKKLALALQERKYAIEDLKDQKQKMIEHLNLDDKELVK 4315
Query: 2881 LQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNL-EEIKFCL 2939
Q + ++ W +K + +LE+ + + + L W ++ Q N+ E +K
Sbjct: 4316 EQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSP 4375
Query: 2940 DPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQK-VD 2998
P +N + ++ E++ +++ L A+ +++ +++ V + S Q V+
Sbjct: 4376 PPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVN 4435
Query: 2999 MVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYS-NKYLTM 3057
+++ + ++ L + +F ++ Q+Q + ++ + + +K +
Sbjct: 4436 CLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKT 4495
Query: 3058 LQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKC 3117
++ Q SL+ +++V ++L+ E ++ + S+VL +++ + + ++ Q+ +
Sbjct: 4496 CKSAQASLKTYQNEVTGLWAQGRELMKEVTEQE-KSEVLGKLQELQSVYDSVLQKCSHRL 4554
Query: 3118 SFLETKLQGIGHFQ------------------------NTIREMFSQFAEFDDELDSMAP 3153
LE L HF+ N E+ +Q A++ + L+
Sbjct: 4555 QELEKNLVSRKHFKEDFDKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPE 4614
Query: 3154 VGRDAETLQKQKETIKAFL---------KKLEAL--------MASNDNANKTCKMMLATE 3196
TLQ+ +TI L +KL AL + D K + +LA +
Sbjct: 4615 YENLLLTLQRTGQTILPSLNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILARK 4674
Query: 3197 E-------TSPDLVGIKRDL-------------EALSKQ--CNKLLDRA----------- 3223
E T+ L ++ EALS Q C +LD
Sbjct: 4675 EYASLIELTTQSLSELEAQFLRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVDELN 4734
Query: 3224 QARE-------------------------EQVEGTIKRLEEFYSKLKEFSILLQKAEEH- 3257
Q +E Q E + LE+ S +E + Q+ E
Sbjct: 4735 QKKEGFRSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQL 4794
Query: 3258 ---EESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGL---IQSAAKST 3311
+E Q V ET ++L M+ L G QD + + + ++ A
Sbjct: 4795 KSVKEEQSKVNEETLPAEEKLKMY--------HSLAGSLQDSGIVLKRVTIHLEDLAPHL 4846
Query: 3312 STQGLE---HDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEEL 3368
E H + K L + + + + ++ FQ + L W+ +
Sbjct: 4847 DPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAE 4906
Query: 3369 VANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIK-REGEKIATTAE--PADKVKI 3425
++ + ++ +I++ ++ Q + + + +E EK E AD
Sbjct: 4907 LSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHS 4966
Query: 3426 LKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIG 3485
L +LS LD + L TR L I Q++++ + N+WL ++ L+ G
Sbjct: 4967 LAELSELDGDIQEAL---RTRQATLTEIYSQCQRYYQVFQAANDWLEDAQE-LLQLAGNG 5022
Query: 3486 TQASKLEEQIAQHK---ALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQ 3542
EE + H + ED ++ + LH V+ L + +ED + + L+
Sbjct: 5023 LDVESAEENLKSHMEFFSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRS 5082
Query: 3543 VWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLS-VQDYSTEGLW 3601
+ S ++ +LLQ+ + + E++ +N+ KLS+ S ++ S+
Sbjct: 5083 Q---RMSRDSGAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAE 5139
Query: 3602 KQQSELRVL-------QEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARY 3654
++ SE + L E I+ ++ Q G + K T + + + ++A
Sbjct: 5140 EKLSEHKALVSVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVA 5199
Query: 3655 KDITKLSTD-----------VAKTLEQALQLARRL------HSTHEELCTWLDKVEVELL 3697
+D K+ D V K E QL +L ++ EL T L+ + +L
Sbjct: 5200 QDQEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVL 5259
Query: 3698 SYETQ--------------------VLKGEE-----------------ASQAQMRPKELK 3720
E Q GEE + + K +K
Sbjct: 5260 ELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVK 5319
Query: 3721 KEAKNNKALLDSLN------------------EVSSALLEL-----VPWRAREGLEKMVA 3757
+E K+ + + +N E+ + L EL R+ +EKM
Sbjct: 5320 QELKDREMVETQINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAE 5379
Query: 3758 EDNERYR-----LVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIR 3812
E E+Y L S+ Q E +R Q D+ + E S T E +S +
Sbjct: 5380 EQKEKYLGLYTILPSELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQE---LSRQIQK 5436
Query: 3813 LEQDQTSAQLQVQKTFTMEILR----HKDIIDDLVKSGHKIMTACSEEEK---------Q 3859
L +D T+ L K T +++ K + ++L K+M + +K +
Sbjct: 5437 LAKDLTTI-LTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGK 5495
Query: 3860 SMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPA 3919
+ KK+ K+ + + + R +L +A S + ++ E E + W+ E +++
Sbjct: 5496 PLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWI-EKAKVLAHGTI 5554
Query: 3920 PALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTL 3979
LR+Q H+ L E E ++ M + L + E S Q + +T
Sbjct: 5555 AWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRET- 5613
Query: 3980 YSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEK--IKE 4037
++++ +K R L +A +F ++ ++ +LE+ L P EV + +KE
Sbjct: 5614 -EELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSP-----EVGRLSLKE 5667
Query: 4038 QISENKNVSVDMEKLQP------LYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVF 4091
Q+S +++ +ME L+P L ++ + E+++A +A +Q++ ++
Sbjct: 5668 QLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVA---SLPLCHAALRLQEEASRLQ- 5723
Query: 4092 IWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQ 4151
HT +++ V++ E++ + L I+ R++ED + S +++
Sbjct: 5724 -----HTAIQQCNIMQAAVVQY-EQYEQEMKHLQQLIEGAH---REIEDKPVATSNIQEL 5774
Query: 4152 Q---EAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKA 4208
Q E + ++I G QE++ + + L + ++ L + L+
Sbjct: 5775 QAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLD-- 5832
Query: 4209 WKDRIDKLEEAMQAAVQYQDG-LQAVFDWVDIAGGK------------LASMSPIGTDLE 4255
+ A + V G + V G+ S SP+
Sbjct: 5833 --GELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPSPVANTDA 5890
Query: 4256 TVKQQIEELKQFKSEAYQQQIEMERLN------HQAELLLKKVTEESDKHTVQDPLMELK 4309
+V Q I AY Q + ERL H + ++ E + + L +L+
Sbjct: 5891 SVNQDI---------AYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQ 5941
Query: 4310 LIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEI 4369
W++L+ I +Q L AL ++Q +L + + E LSE G P E
Sbjct: 5942 RSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSP---ES 5998
Query: 4370 ELAKHHVLQNDVLAHQSTV-EAVNKAGNDLIESSAGEEASN---LQNKLEVLNQRWQNVL 4425
++A+H L +++L Q + E + +L+ S + + LQ+ L VL +R +
Sbjct: 5999 QMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIR 6058
Query: 4426 EKTEQRKQQLDGAL-------RQAKG---FHGEIEDLQQWLTDTERHLLASKPLGGLPET 4475
K ++Q L+ L RQ + + E ++L WL T+ L + P
Sbjct: 6059 MKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPMD 6118
Query: 4476 AKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQ---DINNLKEKWES 4532
+ QL + E K L + +L + +Q + LK
Sbjct: 6119 MEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLE 6178
Query: 4533 VETKLNERKTKLEEALNLAMEFHNSLQDFI--------NWLTQAEQTLNVASRPSLILDT 4584
++ L++++ ++ A E S D WL QA T + SL
Sbjct: 6179 LQRALHDKQLNMQ---GTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQQQK 6235
Query: 4585 VLFQ-IDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIK--------NLLISV 4635
L Q + E K V S E+I+ +K DV+ + + +
Sbjct: 6236 ELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAEDQM 6295
Query: 4636 QSRWEKVVQRLVERGRSLDDARKRAKQ--FHEAWSKLMEWL--------EESEKSLDSEL 4685
+ +WE + Q + + L + ++ ++ + ++L+ + + + ++ S L
Sbjct: 6296 RMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLL 6355
Query: 4686 EIANDP-DKIKTQLAQHKEFQKSLGAKHSVYDTTNRT----------------------- 4721
+ N +++ +Q K ++S+ + +YD + T
Sbjct: 6356 DGLNQAFEEVSSQSGGAK--RQSIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEETE 6413
Query: 4722 ---------GRSLKEKTSLADDNLKL--------DDMLSELRDKWDTICGK-----SVER 4759
+ +KE + D N L D + D + G+ SV
Sbjct: 6414 TCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVN 6473
Query: 4760 Q------NKLEEALLFSGQFTDALQALIDWLYRVEPQLAE--DQPVHGDIDLVMNLIDNH 4811
Q +L++ L F +L D Y + +LA +QPV I+ + D
Sbjct: 6474 QRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGL 6533
Query: 4812 KAFQK---ELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQ 4868
K F EL +R +Q + S +EL +L ++ + + S++
Sbjct: 6534 KEFDAGIIELKRRGDKLQVEQPSMQEL---------------SKLQDMYDELMMIIGSRR 6578
Query: 4869 TRLEAALRQAEEFHSVVHALLEWLAEAEQTLR-FHGVLPDDEDALRTLIDQHKEFMKKLE 4927
+ L L ++ + L + L ++ + ++ ++ ++ L+D+HKE+ + LE
Sbjct: 6579 SGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLE 6638
Score = 210 bits (535), Expect = 3e-53
Identities = 144/429 (33%), Positives = 219/429 (51%), Gaps = 65/429 (15%)
Query: 68 RIADERDKVQKKTFTKWINQHLMKVRKH--VNDLYEDLRDGHNLISLLEVLSGDTLPREK 125
R+ DE++ VQK+TFTKWIN HL K + V+DL+ED++DG L++LLEVLSG LP E+
Sbjct: 20 RLQDEQEIVQKRTFTKWINSHLAKRKPPMVVDDLFEDMKDGVKLLALLEVLSGQKLPCEQ 79
Query: 126 GRM--RFHRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIH 183
GR R H + N+ AL +L+ R++KLVNI + DI DG P + LGL+WTIIL+FQI ++
Sbjct: 80 GRRMKRIHAVANIGTALKFLEGRKIKLVNINSTDIADGRPSIVLGLMWTIILYFQIEELT 139
Query: 184 -------------------VTGESEDM------------SAKERLLLWTQQATEGYAGIR 212
V+ E+ +AK+ LL W Q GI
Sbjct: 140 SNLPQLQSLSSSASSVDSIVSSETPSPPSKRKVTTKIQGNAKKALLKWVQYTAGKQTGIE 199
Query: 213 CENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAVQSNLANLEHAFYVAE-KIGVIRLLDPE 271
++F WR G F+++IH RP+L+D+ TV +SN NLE AF +AE ++G+ RLLDPE
Sbjct: 200 VKDFGKSWRSGVAFHSVIHAIRPELVDLETVKGRSNRENLEDAFTIAETELGIPRLLDPE 259
Query: 272 DVDVSSPDEKSVITYVSSLYDAFPKVPEGG-EGIGANDVEVKWIEYQNMVNYLIQWIRHH 330
DVDV PDEKS++TYV+ +P + +G +++ + + N V + R
Sbjct: 260 DVDVDKPDEKSIMTYVAQFLKHYPDIHNASTDGQEDDEILPGFPSFANSVQNFKREDRVI 319
Query: 331 VTTMS------ERTFPNNPVELKALYNQYLQFKETEIPPKETEKSKIKRLYKLLEIWIEF 384
M ER + L ++Y FK + + K K++ L++
Sbjct: 320 FKEMKVWIEQFERDLTRAQMVESNLQDKYQSFKHFRV----QYEMKRKQIEHLIQPLHRD 375
Query: 385 GRIKLLQGYHPNDIEK------EW------------GKLIIAMLEREKALRPEVERLEML 426
G++ L Q ++ +W G + + E ALR E+ ++
Sbjct: 376 GKLSLDQALVKQSWDRVTSRLFDWHIQLDKSLPAPLGTIGAWLYRAEVALREEITVQQVH 435
Query: 427 QQIANRVQR 435
++ AN +QR
Sbjct: 436 EETANTIQR 444
Score = 162 bits (411), Expect = 7e-39
Identities = 417/2186 (19%), Positives = 829/2186 (37%), Gaps = 298/2186 (13%)
Query: 1049 LSNLQSRFEDFLEDSQESQV-FSGSDITQLEKEVNVC-KQYYQELLKSAEREEQEESVYN 1106
L+ Q + L+D + + S SD+ ++ C ++ K R E +
Sbjct: 6739 LNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWT 6798
Query: 1107 LYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTI 1166
Y SE ++ L++ +DRL F + + +ELE ++D L
Sbjct: 6799 RYQSESADLIHWLQSAKDRL----------------EFWTQQSVTVPQELEMVRDHLNAF 6842
Query: 1167 TNKCEEFFSQAAASSSV---------------PTLRSELNVVLQNMNQVYSMSSTYIDKL 1211
+E +Q++ SSV TLRSEL+ + + + +KL
Sbjct: 6843 LEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKL 6902
Query: 1212 KTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLIS---------TLKQWRSEV 1262
L + + A+ ++ E + D++NI+N I K ++ ++
Sbjct: 6903 H--QLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDI 6960
Query: 1263 DEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRL 1322
+ K+ + Q IS + ++ + DF E+ + + WQ + + ++
Sbjct: 6961 NCKQLTVDFVN---QSVLQISSQDVESKRSDKTDF---AEQLGAMNKSWQILQGLVTEKI 7014
Query: 1323 RDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIE 1382
+ LEG+ +S Y + L W + E +R Q+++ + ++ L + L I+
Sbjct: 7015 QLLEGLLESWSEYENNVQCLKTWFETQE--KRLKQQHRIGDQASVQNALKDCQDLEDLIK 7072
Query: 1383 MKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMD 1442
K+ ++++ ++ K+ ++ ++ + + Q + M ++++ +D
Sbjct: 7073 AKEKEVEKIEQNGLALIQNKKE-DVSSIVMSTLRELGQ-TWANLDHMVGQLKILLKSVLD 7130
Query: 1443 LRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKD 1502
+ + + Y+ A SL R SLE +Q V N+ D
Sbjct: 7131 QWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEA-----------VQVQVDNLQNLQDD 7179
Query: 1503 AEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQ 1562
EK + S QK S KE +T L +K +
Sbjct: 7180 LEKQER---SLQKFGSITNQLLKECHPPVTET-------------------LTNTLKEVN 7217
Query: 1563 ESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQE 1622
+N L E +QLQ S K + + Q YK+ + + Q E+R
Sbjct: 7218 MRWNNLLEEIAEQLQSS----------KALLQLWQRYKDYSKQCASTVQQQEDR------ 7261
Query: 1623 AFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEV------VKNTENFLKENGEKLSQED 1676
T EL K + ++ ++ Q ++ VK++ FL E GE+L Q+
Sbjct: 7262 -------TNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQV 7314
Query: 1677 KALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENL 1736
A + ++ Q EQ+ K++T A V E +E L
Sbjct: 7315 DASAASAIQSDQLSLSQHLCALEQA----------LCKQQTSLQAGVLDYETFAKSLEAL 7364
Query: 1737 LDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTT 1796
W+ ++ + H + T
Sbjct: 7365 EAWIVEAEEILQGQDPSHSS-----------------------------------DLSTI 7389
Query: 1797 QENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKV 1856
QE + +++K Q K S + L + G L +KE K M+ L
Sbjct: 7390 QERM----EELKGQMLKFSSMAPDLD--------RLNELGYRLPLNDKEI--KRMQNLNR 7435
Query: 1857 HYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTK 1916
H+ +++ ++ S + + F + +L Q+EQ+L +G + L+ +
Sbjct: 7436 HWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISG--NYQHLLEQ 7493
Query: 1917 LKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHAT 1976
+ + F ++ S + L I I G R+LE G+VD E KL +
Sbjct: 7494 QRAHELFQAEMFSRQQILHSIIIDGQRLLEQ---------GQVDD---RDEFNLKLTLLS 7541
Query: 1977 DRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHL-SEPIAVDPKN 2035
++++ + + + + ++Q Y + + L L L S PI +
Sbjct: 7542 NQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQAR 7601
Query: 2036 L---QRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRY 2092
+ Q +E L+ Q S + VE K ++LL A A+ +Q L +I ++
Sbjct: 7602 TLFDEVQFKEKVFLRQQ-GSYILTVEAGK---QLLLSADSG---AEAALQAELAEIQEKW 7654
Query: 2093 EDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIIS 2152
+ S + E+ +KL L + G+ + L+ + + L + +P + L
Sbjct: 7655 KSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQS--LPDHHEELHAEQM 7712
Query: 2153 KNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETL 2212
+ LE + + ++ S L +++ L ++ E H +
Sbjct: 7713 RCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCH---QLS 7769
Query: 2213 AKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTE-----LSQYMQESTSEF 2267
+ +++ ++ + SEK + E TQ ++V G + E L + QE +
Sbjct: 7770 LRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLKKDYQEEIAIA 7829
Query: 2268 LEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEM-EDTIKEKKEAVTSCQE 2326
E+K L+ + L + S S+ L K N+ + ++ +K+ KE + + Q
Sbjct: 7830 QENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQ- 7888
Query: 2327 QLDAFQVLVKSLKSWIKETTKKV--PIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQK 2384
QLD + SL++W+ ++ PIV S +E++ + L + ++LQ +I+K
Sbjct: 7889 QLDKN---MSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQR-------DIEK 7938
Query: 2385 VNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDI 2444
+ S+ NL + A A T+ E SI++ ++
Sbjct: 7939 HSTGVASVLNLCEVLLHDCDACA---------------TDAE-------CDSIQQATRNL 7976
Query: 2445 SHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEA 2504
+ ++ + ++ ++ QK ++ S WL+ +TA + + T A
Sbjct: 7977 DRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAA-FPSSSGVIYTVA 8035
Query: 2505 VKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELN 2564
K ++++ ++F+ ++ + + +++ + + L EN T A KQM+ E + +W L
Sbjct: 8036 -KEELKKFEAFQRQVHECLTQLELINKQYRRLARENR-TDSACSLKQMVHEGNQRWDNLQ 8093
Query: 2565 QLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQI 2624
+ ++L+ +F+T + WL E +L ++ + S + + +Q++
Sbjct: 8094 KRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFS--ECDVQAKIKQLKA 8151
Query: 2625 LLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDW 2684
QE + + EQ+ A G+ ++ + +P I++E+L + + + G++
Sbjct: 8152 FQQEISLNHNKIEQIIAQGEQLIEK--SEPLDAAIIEEELDELRRYCQEVFGRVERYHKK 8209
Query: 2685 IDQAIVKSTQYQSLLRSL----SDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEI 2740
+ + + ++ R L S LSDL S+ ++ + + N L AQ ++ E
Sbjct: 8210 LIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSER 8269
Query: 2741 QQEKKQIKVAQALCE-----DLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHL 2795
V E DLS ++ +A S EG + KD + +
Sbjct: 8270 SGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEG--QDDKDFYLRGAVGLSGD 8327
Query: 2796 QSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSH 2855
SA S Q +Q+ + A D++ + Q + I +K L +K + K L S
Sbjct: 8328 HSALES--QIRQLGK---ALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSS 8382
Query: 2856 MYEKTIAEGENLLLKTQGSEKAALQLQLNTIKT-----NWDTFNKQVKERENKLKESLEK 2910
+ ++ E+ L + + S + L +T W+ Q +E ++K++L+K
Sbjct: 8383 SID-SVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQK 8441
Query: 2911 ALKYKEQVETLWPWIDKCQNNLEE---IKFCLDPAEGENSIAKLKSLQKEMDQHFGMVEL 2967
++ + ++W W+ + LE+ ++ D E I KLK LQK +D ++
Sbjct: 8442 WQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILS 8501
Query: 2968 LNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKE 3027
+N + + + D + + D V L + L++ + + F E+S
Sbjct: 8502 INLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMS-- 8559
Query: 3028 SKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQV---DLAKRLAQDLVV 3084
L E +D + SN +LQ K L +KH++ L QD+
Sbjct: 8560 --HGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSC 8617
Query: 3085 E-ASDSKGTS--DVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQF 3141
+ +++GT + +V I L ++V LE KL + Q + S
Sbjct: 8618 QLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELE-KLLDVSSSQQDLSSWSSA- 8675
Query: 3142 AEFDDELDSMAPV----GRDAETLQK 3163
DELD+ V GR QK
Sbjct: 8676 ----DELDTSGSVSPTSGRSTPNRQK 8697
Score = 54.7 bits (130), Expect = 3e-06
Identities = 93/447 (20%), Positives = 181/447 (40%), Gaps = 79/447 (17%)
Query: 4640 EKVVQRLVERGR-SLDDARKRAKQFHEAWSKLMEWLEESEKSLDSEL----------EIA 4688
E ++Q L G+ SLD A + + + S+L +W + +KSL + L E+A
Sbjct: 366 EHLIQPLHRDGKLSLDQALVK-QSWDRVTSRLFDWHIQLDKSLPAPLGTIGAWLYRAEVA 424
Query: 4689 ------------NDPDKIKTQLAQHKEFQKSLGAK----HSVYDTTNRTGRSLKEKTSLA 4732
+ I+ +L QHK+ ++ A H +Y T + G +
Sbjct: 425 LREEITVQQVHEETANTIQRKLEQHKDLLQNTDAHKRAFHEIYRTRSVNGIPVP------ 478
Query: 4733 DDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLA 4792
D L ++ +++ + S E L +F + L+ L E +L
Sbjct: 479 ------PDQLEDMAERFHFVSSTS--------ELHLMKMEFLELKYRLLSLLVLAESKLK 524
Query: 4793 EDQPVHGDIDLVMNLIDNHKAF---QKELGKRTSSVQALKRSARELI--EGSRDDSSWVK 4847
+G + V L+ N+ +F K + + Q LK++A + +GS +++ V
Sbjct: 525 SWIIKYGRRESVEQLLQNYVSFIENSKFFEQYEVTYQILKQTAEMYVKADGSVEEAENVM 584
Query: 4848 VQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPD 4907
M E + +W + S ++ LE + + + + V +L WL +AE+ +L
Sbjct: 585 KFMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEK------MLNQ 638
Query: 4908 DEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFE 4967
E+A K+F + L + G+ ++ C +K + ++ R+
Sbjct: 639 SENA-------KKDFFRNLPHWIQQHTAMNDAGNFLIETCDEMVSRDLKQQLLLLNGRWR 691
Query: 4968 EVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALI 5027
E+ KQ+ Q A + + K+E + ++ +A T K E + VK LI
Sbjct: 692 ELFMEVKQYAQ--ADEMDRM--KKEYTDCVVTLSAFA-TEAHKKLSEPLEVSFMNVKLLI 746
Query: 5028 AEHQTFMEEMTRKQPDVDK----VTKT 5050
+ +E++ ++ P +D +TKT
Sbjct: 747 QD----LEDIEQRVPVMDAQYKIITKT 769
Score = 33.5 bits (75), Expect = 6.0
Identities = 72/362 (19%), Positives = 139/362 (38%), Gaps = 66/362 (18%)
Query: 4733 DDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLA 4792
D L LD L ++ WD + + + +L+++L L + WLYR E L
Sbjct: 375 DGKLSLDQAL--VKQSWDRVTSRLFDWHIQLDKSL------PAPLGTIGAWLYRAEVALR 426
Query: 4793 EDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKV-QMQ 4851
E+ V + N I K+L + T A KR+ E+ + V Q++
Sbjct: 427 EEITVQQVHEETANTIQRKLEQHKDLLQNT---DAHKRAFHEIYRTRSVNGIPVPPDQLE 483
Query: 4852 ELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDA 4911
+++ R+ V + S ++ EF + + LL L AE L+ + ++
Sbjct: 484 DMAERFHFVSSTSELHLMKM--------EFLELKYRLLSLLVLAESKLKSWIIKYGRRES 535
Query: 4912 LRTLIDQHKEF----------------MKKLEEKRAELNKATTMGDTVLAICHPDSITTI 4955
+ L+ + F +K+ E + + + + V+ + T
Sbjct: 536 VEQLLQNYVSFIENSKFFEQYEVTYQILKQTAEMYVKADGSVEEAENVMKFMN----ETT 591
Query: 4956 KHW------ITIIRARFEEVLAWAKQHQQRLASALAGL-----------IAKQELLEALL 4998
W + +R+ EEV++ ++ +AS A L AK++ L
Sbjct: 592 AQWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQSENAKKDFFRNLP 651
Query: 4999 AWLQW------AETTLTDKDKEVIPQEIEEVKALI--AEHQTFMEEMTRKQPD-VDKVTK 5049
W+Q A L + E++ +++++ L+ + FME Q D +D++ K
Sbjct: 652 HWIQQHTAMNDAGNFLIETCDEMVSRDLKQQLLLLNGRWRELFMEVKQYAQADEMDRMKK 711
Query: 5050 TY 5051
Y
Sbjct: 712 EY 713
>gi|5032281 dystrophin Dp427c isoform [Homo sapiens]
Length = 3677
Score = 325 bits (832), Expect = 1e-87
Identities = 545/2835 (19%), Positives = 1126/2835 (39%), Gaps = 316/2835 (11%)
Query: 2230 EKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHL-----------EVLH 2278
++ QT LE L + + E+S ++ +F H+ ++ +L
Sbjct: 334 DRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNILQ 393
Query: 2279 SLLKEISSHGLPSDKAL-VLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKS 2337
K I + L D+ V E+ N L+ +++ + EK+ + + +D +K
Sbjct: 394 LGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLH--RVLMDLQNQKLKE 451
Query: 2338 LKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLIS 2397
L W+ +T ++ ++ E LG LED K+ ++ + ++++ SL +++
Sbjct: 452 LNDWLTKTEERTRKMEE----EPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVV 507
Query: 2398 AVTTPA--KAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLL 2455
V + A AA++ VL WAN I ED +LL
Sbjct: 508 VVDESSGDHATAALEEQLKVLGDR---------WAN------------ICRWTEDRWVLL 546
Query: 2456 KDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSF 2515
+D L K Q+ EE WL + K T E + + +++
Sbjct: 547 QDI-------LLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSS-LQKLAVL 598
Query: 2516 EAEL---KQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEI-DSKWQELNQLTIDRQ 2571
+A+L KQ++ K+ LK L L+ T + W D+ Q+L + T
Sbjct: 599 KADLEKKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQIS 658
Query: 2572 QKLEESSNNLTQFQTVEA------------------------------------------ 2589
Q + + +LTQ +E
Sbjct: 659 QAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDV 718
Query: 2590 ---QLKQWLVEKELMV-SVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQG 2645
+L W+ E ++ S + + +++V + +E A + + + + + Q
Sbjct: 719 DITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQA 778
Query: 2646 ILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDK 2705
++ + + +K+ + +W LS+R +W++ + + L+ L
Sbjct: 779 LVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQN-NIIAFYNQLQQLEQM 837
Query: 2706 LSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEE- 2764
+ +N L + P A+ QL+ + + + QI+ + S +KE+
Sbjct: 838 TTTAENWLKIQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQ----SIALKEKG 893
Query: 2765 ----YLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKK 2820
+L A+ + F DV+ + E +Q + ++Q+ + W+ +
Sbjct: 894 QGPMFLDADFVAFTNHFKQVFSDVQAR-EKELQTIFDTLPPM-RYQETMSAIRTWVQQSE 951
Query: 2821 EEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQ 2880
+ + +++E + + + +L Q + + K Q
Sbjct: 952 TKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQ 1011
Query: 2881 LQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLD 2940
+ I+ W + Q+ E KL+E + K K + ++TL W+ + L+E
Sbjct: 1012 SEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEW---- 1067
Query: 2941 PAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTD-----------E 2989
PA G++ I L+K++ Q +V + SL SV E +++ + E
Sbjct: 1068 PALGDSEI-----LKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETE 1122
Query: 2990 NKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQA 3049
K L + D + +Q++++K L+ +K Q+ E + A+E+ D
Sbjct: 1123 LKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERD------ 1176
Query: 3050 YSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTL 3109
+ K LQ + ++ K + K L+ E+ +S + E + +E TL
Sbjct: 1177 FEYKTPDELQKAVEEMKRAKEEAQ-QKEAKVKLLTESVNSVIAQAPPVAQEALKKELETL 1235
Query: 3110 SQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIK 3169
+ C+ L K + + E+ S + + L+ + + E + E I
Sbjct: 1236 TTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEIS 1295
Query: 3170 AFLKKLEALMA-SNDNANKTCKMMLATEETSPDLVG--IKRDLEALSKQCNKLLDRAQAR 3226
L LE LM S DN N+ +LA T ++ I +LE + + +L + A R
Sbjct: 1296 EVLDSLENLMRHSEDNPNQI--RILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRR 1353
Query: 3227 EEQVEGTIKRLEEFYSKL---KEFSILLQK------AEEHEESQGPVGMETETINQQLNM 3277
++ +E +I+ +E L +E + K A++ + +Q P E + I L
Sbjct: 1354 QKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMP--QEAQKIQSDLTS 1411
Query: 3278 FKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQR 3337
++ +E + QGK+ L Q I A K L DV+ +++ L +K A
Sbjct: 1412 HEISLEEMKKHNQGKEAAQRVLSQ--IDVAQKK---------LQDVSMKFR-LFQKPANF 1459
Query: 3338 AAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLD 3397
+LQE+ + + L +L + S E +VV++Q+ L + L
Sbjct: 1460 EQRLQESKMILDEVKMHLPAL--------------ETKSVEQEVVQSQLNHCVNLYKSLS 1505
Query: 3398 DRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVA 3457
+ KS VE++ + G +I + + ++ ++++ L + L K R +QLE ++
Sbjct: 1506 EVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLS 1565
Query: 3458 QQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVS 3517
++ + + L EWL + L + S L+ ++A KA + +I HL
Sbjct: 1566 RKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITE 1625
Query: 3518 IGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELM 3577
+G++LK + +++ +V+ KL +I + ++ LL + + + F ++ +
Sbjct: 1626 VGEALKTVLGKKET-LVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHIT 1684
Query: 3578 NWLNEVHDKL--SKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQT 3635
W+ + L S+ + L + ++EL ++ + + + N + ++
Sbjct: 1685 KWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKL 1744
Query: 3636 TGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVE 3695
++ + + AI R K T ++ K LEQ ++L L+ +E E
Sbjct: 1745 VEPQISELNHRFAAISHRIK--TGKASIPLKELEQFNSDIQKL----------LEPLEAE 1792
Query: 3696 LLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKM 3755
+ + LK E+ + K++ ++ N + + L + + R RE ++
Sbjct: 1793 I--QQGVNLKEEDFN------KDMNED--NEGTVKELLQRGDNLQQRITDERKREEIKIK 1842
Query: 3756 VAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQ 3815
++ + D +Q+ ++ + Q+ + AD L + + EKKL SL + R E+
Sbjct: 1843 QQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDER 1902
Query: 3816 D--QTSAQLQVQKTFTMEILRHKDII--DDLVKSGHKIMTACSEEEKQSMKKKLDKVLKN 3871
+ +LQ +K + R + + D + S+ ++ K N
Sbjct: 1903 KIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLN 1962
Query: 3872 YDTICQINSERYLQLERAQSL-VNQFWETY----EELWPWLTETQSIISQLPAPALEYET 3926
+ I + E + + L ++ TY + L E + +++ A ++E
Sbjct: 1963 FAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFED 2022
Query: 3927 LRQQQEEHRQLRELIAEHKPHIDKMN-KTGPQLLELSPGEGFSIQEKYVAADTLYSQIKE 3985
L +Q+E + +++ + + ID ++ K L +P E +QE D + ++ +
Sbjct: 2023 LFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNK 2082
Query: 3986 DVKKRAVALDEAISQSTQFHDKI---DQILESLERIVERLRQPPSISAEVEKIKEQISEN 4042
K R D ++ + +FH I +Q L E+ + + + P + E K K + E
Sbjct: 2083 MYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENW--EHAKYKWYLKEL 2140
Query: 4043 KNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEE 4102
++ + + Q + TL GEE+I +S TD I +Q+KL + W+ + + +
Sbjct: 2141 QD---GIGQRQTVVRTLNATGEEIIQQSSKTDASI----LQEKLGSLNLRWQEVCKQLSD 2193
Query: 4103 REAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEI 4162
R+ +L + + +F D ++ +++ + +PG + + K++ E + + EE+
Sbjct: 2194 RKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQL-KEKLEQVKLLVEEL 2252
Query: 4163 DGLQEELDIVINLGSELIAACG----EPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEE 4218
Q L + G ++ + E DK ++ + + N W +++A ++ ++E
Sbjct: 2253 PLRQGILKQLNETGGPVLVSAPISPEEQDK--LENKLKQTNLQWIKVSRALPEKQGEIEA 2310
Query: 4219 AMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEE----LKQFKSEAYQQ 4274
++ Q + L+ D + L +SPI LE Q +E +++ + +
Sbjct: 2311 QIKDLGQLEKKLE---DLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAK 2367
Query: 4275 QIEMERLNHQAELLLK-KVTEESDKHTVQDPLMELKLIWDSLEER--------------- 4318
Q ++E + + + L K K + K ++D E K + L+E
Sbjct: 2368 QPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIG 2427
Query: 4319 -------------IINRQ---HKLE--GALL----ALGQFQHALDELLAWLTHTEGLLSE 4356
++ ++ KLE +L+ AL F A EL WL+ + ++
Sbjct: 2428 ASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKS 2487
Query: 4357 QKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNL-QNKLE 4415
Q+ + GD + I + K D+ + +E + A +L ++ +EA + +++E
Sbjct: 2488 QRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIE 2547
Query: 4416 VLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPET 4475
+ +W V E + R+QQL+ L+ + + E+ +Q L L + K +
Sbjct: 2548 RIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDA 2607
Query: 4476 AKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVET 4535
++++ ++ + ++L + N+ W S+
Sbjct: 2608 IQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHK 2667
Query: 4536 KLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNV---ASRPSLILDT---VLFQI 4589
+++ER+ LEE L +F L+ F+ WLT+AE T NV A+R +L+ V +
Sbjct: 2668 RVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELM 2727
Query: 4590 DEHKVFANEVNSHREQIIELDKTGTH-LKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVE 4648
+ + E+ +H + LD+ L+ D VL++ L ++ +W ++ ++ +
Sbjct: 2728 KQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLN 2787
Query: 4649 RGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSL 4708
L+ + + K+ H + +L+ WL+ + L + I D ++ Q H+ F++ L
Sbjct: 2788 IRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKREL 2847
Query: 4709 GAKHSVYDTTNRT-------------------GRSLKEKTSLADDNLKLDDMLSELRDKW 4749
K V +T T R L + + L E+ +W
Sbjct: 2848 KTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEW 2907
Query: 4750 DTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGD--IDLVMNL 4807
+ + S + Q K++E L + +A L L + E QPV GD ID + +
Sbjct: 2908 EKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPV-GDLLIDSLQDH 2966
Query: 4808 IDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISK 4867
++ KA + E+ +V + AR+L S + +++L+TRW+ +
Sbjct: 2967 LEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLL------- 3019
Query: 4868 QTRLEAALRQAEEFH 4882
Q +E +RQ E H
Sbjct: 3020 QVAVEDRVRQLHEAH 3034
Score = 316 bits (809), Expect = 5e-85
Identities = 548/2809 (19%), Positives = 1128/2809 (40%), Gaps = 353/2809 (12%)
Query: 1879 LEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYIT 1938
L+++ E WL +E L+ ++D+ + + + + D+ +H+G + I
Sbjct: 333 LDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNIL 392
Query: 1939 ISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVD 1998
G++++ K + EVQ +++ R+ L +NL ++
Sbjct: 393 QLGSKLIGTGKLSEDEE----------TEVQEQMNLLNSRWECLRVASMEKQSNLHRVLM 442
Query: 1999 KYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVE 2058
Q+ + L L E K EP+ D ++L+RQ+++ K LQ + +QV V
Sbjct: 443 DLQNQKLKE--LNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVN 500
Query: 2059 KLKKTAEVLLDARGSLLPAKNDIQ-KTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQ 2117
L V+ ++ G A + Q K L D R+ ++ + +R LQ L + +
Sbjct: 501 SLTHMVVVVDESSGDHATAALEEQLKVLGD---RWANICRWTEDRWVLLQDILLKWQRLT 557
Query: 2118 DGLDEMLDWMGNVESSLKEQGQVPLNSTALQD------IISKNIMLEQDIAGRQSSINAM 2171
+ W+ E ++ + +++T +D + K +L+ D+ ++ S+ +
Sbjct: 558 EEQCLFSAWLSEKEDAVNK-----IHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKL 612
Query: 2172 NEKVKKFMETT-DPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSE 2230
+ + T + S +A + + + + K +++ A++ + T + +L++
Sbjct: 613 YSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQ--PSLTQ 670
Query: 2231 KLQTFLETKTQALTEVDVPGKDVTEL-----SQYMQESTSEFLEHKKHLEV----LHSLL 2281
T +ET T T + K E Q ++ T + E +K L+V LHS +
Sbjct: 671 T--TVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDS-EIRKRLDVDITELHSWI 727
Query: 2282 KEISSHGLPSDKALVLEKTNNLS--------------KKFKEMEDTIKEKK--------- 2318
S L S + + K N S +KF++++D + +
Sbjct: 728 TR-SEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNE 786
Query: 2319 ----EAVTSCQEQLDA----FQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKK 2370
+++ EQL++ F L+ +W++ + E + + E+ K
Sbjct: 787 GVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLK 846
Query: 2371 LQEKWSLKTPEIQKVNNSGISLC-NLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFW 2429
+Q TP S + +C + ++ ++ I +K L +G
Sbjct: 847 IQPT----TPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKG--------- 893
Query: 2430 ANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKL--QKAQEESSAMMQWLQKMN 2487
+G + D ++ ++ + ++ + EL T L + QE SA+ W+Q+ +
Sbjct: 894 --QGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQ-S 950
Query: 2488 KTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAP 2547
+T Q TD E ++ ++ + ++ ++ L++ + + L + E+ ++ P + +
Sbjct: 951 ETKLSIPQLSV-TDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAP-SEISR 1008
Query: 2548 RWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGP 2607
+++ EI+ +W++L+ ++ QKLEE N L + Q LK+W+ E ++ + P
Sbjct: 1009 KYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWP 1068
Query: 2608 LSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAV 2667
D +L Q +Q ++L+ + T +P + GQ I + +P ++ +L +
Sbjct: 1069 ALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEA--EPEFASRLETELKEL 1126
Query: 2668 TQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMN 2727
+WD + Q+ R + + + K+ Q L + + ++ + + PD +
Sbjct: 1127 NTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQ 1186
Query: 2728 QQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAE--LSRQLEGILKSFKDVE 2785
+ +E ++ K+E QQ++ ++K+ L E +++++ + A+ L ++LE + +++ +
Sbjct: 1187 KAVEEMKRAKEEAQQKEAKVKL---LTESVNSVIAQAPPVAQEALKKELETLTTNYQWLC 1243
Query: 2786 QKAENHVQHLQSACASSHQFQQMSRDFQAWLD-------TKKEEQNKSHPISAKLDVLES 2838
+ + L+ A H+ WL+ T + + IS LD LE+
Sbjct: 1244 TRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLEN 1303
Query: 2839 LIKDHKD-------FSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQ--------- 2882
L++ +D ++TLT M E E E + + + A++ Q
Sbjct: 1304 LMRHSEDNPNQIRILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQS 1363
Query: 2883 -------LNTIKTNWDTFNKQVK-------------ERENKLKE-------SLEKALKY- 2914
L+ I+ + +KQ+ + K++ SLE+ K+
Sbjct: 1364 AQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHN 1423
Query: 2915 --KEQVETLWPWIDKCQNNLEEI--KFCL--DPAEGENSIAKLKSLQKEMDQHFGMVEL- 2967
KE + + ID Q L+++ KF L PA E + + K + E+ H +E
Sbjct: 1424 QGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETK 1483
Query: 2968 ----------LNNTANSLLSVCEIDKEV--VTDENKSLIQKVDMVTEQLHSKKFCLENMT 3015
LN+ N S+ E+ EV V + ++QK +Q + K E +T
Sbjct: 1484 SVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQK-----KQTENPKELDERVT 1538
Query: 3016 QKFKEFQEVSK---ESKRQLQ-CAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQ 3071
+ E+ E K+QL+ C K + + M T++ +++ +
Sbjct: 1539 ALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSN 1598
Query: 3072 VDL----AKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGI 3127
+D K +++ + K ++V ++T+ + TL V++K S L + +
Sbjct: 1599 LDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETL---VEDKLSLLNSNWIAV 1655
Query: 3128 G----HFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASND 3183
+ N + E FD +D + A+TL + E K K+ + L
Sbjct: 1656 TSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKE-DVLKRLKA 1714
Query: 3184 NANKTCKMMLATEETSPDLVGIKRD--LEALSKQCNKLLDRAQAREEQVEG-----TIKR 3236
N + +T + + +L+ + D + + Q ++L R A +++ +K
Sbjct: 1715 ELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKE 1774
Query: 3237 LEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDV 3296
LE+F S +++ LL+ E E Q V ++ E N+ +N E +G +++
Sbjct: 1775 LEQFNSDIQK---LLEPLEA--EIQQGVNLKEEDFNKDMN----------EDNEGTVKEL 1819
Query: 3297 NWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALE 3356
G L Q + ++ + + L +QR + E +++ +
Sbjct: 1820 LQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQAD 1879
Query: 3357 SLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKI--- 3413
LL + D E+ +A+ P E K+ K + R L +K + ++R+ E +
Sbjct: 1880 DLLKCLDDIEKKLASLPEPRDERKI--------KEIDRELQKKKEELNAVRRQAEGLSED 1931
Query: 3414 --ATTAEPADKVKILKQLSLLDSRWEAL--LNKAE------------TRNRQLEGISVVA 3457
A EP ++++ K+ ++S++ LN A+ T + LE IS V
Sbjct: 1932 GAAMAVEPT-QIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLE-ISYVP 1989
Query: 3458 QQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHL---HQ 3514
+ + +++ L +E+ L + L +Q K ++D + + + H
Sbjct: 1990 STYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHS 2049
Query: 3515 AVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEV 3574
+ R S+LDF + ++ + R +++ + F D
Sbjct: 2050 KKTAALQSATPVERVKLQEALSQLDFQ---WEKVNKMYKDRQGRFDRSVEKWRRFHYDIK 2106
Query: 3575 ELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQ 3634
WL E L K + + +K L+ LQ+ I R+ V G E+++Q
Sbjct: 2107 IFNQWLTEAEQFLRKTQIPENWEHAKYKWY--LKELQDGIGQRQTVVRTLNATGEEIIQQ 2164
Query: 3635 TTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEV 3694
++ + I+Q+KL ++ R++++ K +D K LE+ + E WL++ +
Sbjct: 2165 SSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEAD- 2223
Query: 3695 ELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREG--L 3752
+ S + K ++ + + K L +E + +L LNE +L P E L
Sbjct: 2224 NIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKL 2283
Query: 3753 EKMVAEDNERYRLVSDTITQKVEEIDAAIL-------RSQQFDQAADAELSWITETEKKL 3805
E + + N ++ VS + +K EI+A I + + ++ + L W++ +L
Sbjct: 2284 ENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQL 2343
Query: 3806 MSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKL 3865
Q VQ+T + D+ + L K H + Q +K+KL
Sbjct: 2344 EIYN-----QPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYK---EKPATQPVKRKL 2395
Query: 3866 DKVLKNYDTICQINSE-RYLQLERAQ-------------SLVNQFWETYEELWPWLTETQ 3911
+ + + + ++ E R Q + A +LV Q T E L
Sbjct: 2396 EDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPS 2455
Query: 3912 SIISQLPAPA--------------LEYETLRQQQE---EHRQLRELIAEHKPHIDKMNKT 3954
S++ ++PA A L + ++ Q+ + + E+I + K + + +
Sbjct: 2456 SLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQR 2515
Query: 3955 GPQLLEL-----------SPGEGFSI-QEKYVAADTLYSQIKEDVKKRAVALDEAISQST 4002
PQL EL S E +I ++ + +++E ++ R L+E + ST
Sbjct: 2516 RPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDST 2575
Query: 4003 QF---HDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETL 4059
Q+ ++ +Q+L +E ++ P V+ I+++I+E K ++ D+ + Q +
Sbjct: 2576 QWLEAKEEAEQVLGQARAKLESWKEGPYT---VDAIQKKITETKQLAKDLRQWQTNVDVA 2632
Query: 4060 KQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWC 4119
+++ R D + + ++ W +IH V EREA L + L ++F
Sbjct: 2633 NDLALKLL-RDYSADDTRKVHMITENINAS---WRSIHKRVSEREAALEETHRLLQQFPL 2688
Query: 4120 DHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEEL----DIVINL 4175
D + + + + L+D +++ + E +++ D LQ E+ D+ NL
Sbjct: 2689 DLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQD-LQGEIEAHTDVYHNL 2747
Query: 4176 GSE----LIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQ 4231
L + G D ++++ +D +N W L K + LE + + LQ
Sbjct: 2748 DENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQ 2807
Query: 4232 AVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAY------------------Q 4273
+ W+ + +L+ +PIG D V++Q + + FK E +
Sbjct: 2808 ELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTE 2867
Query: 4274 QQIE-MERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLA 4332
Q +E +E+L + L + ++ ++ E+ W+ L + Q K++ L
Sbjct: 2868 QPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLER 2927
Query: 4333 LGQFQHALDELLAWLTHTEGLLSEQKPVGG-DPKAIEIELAKHHVLQNDVLAHQSTVEAV 4391
L + Q A DEL L E + +PVG +++ L K L+ ++ + V V
Sbjct: 2928 LQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHV 2987
Query: 4392 NKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALR 4440
N L NL + LE LN RW+ + E R +QL A R
Sbjct: 2988 NDLARQLTTLGIQLSPYNL-STLEDLNTRWKLLQVAVEDRVRQLHEAHR 3035
Score = 313 bits (803), Expect = 2e-84
Identities = 505/2706 (18%), Positives = 1066/2706 (39%), Gaps = 308/2706 (11%)
Query: 2413 GAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKA 2472
G+ L G G + EE T +++ M ++ +E L + +K + L+ L LQ
Sbjct: 395 GSKLIGTGKLSEDEE-------TEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQN- 446
Query: 2473 QEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDK 2532
++ + WL K + K ++ P D E +K QV+Q+K + +L+Q +V L
Sbjct: 447 -QKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHM 505
Query: 2533 LTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLK 2592
+ + E + D A +Q L + +W + + T DR L++ + +
Sbjct: 506 VVVVDESSGDHATAALEEQ-LKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFS 564
Query: 2593 QWLVEKELMVSVLGPLSI-DPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPG 2651
WL EKE V+ + D N + + Q++ +L + +K +L + Q +LS
Sbjct: 565 AWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTL- 623
Query: 2652 EDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKS-----------------TQ 2694
++ S+ + L + WD+L +L I QA+ + T+
Sbjct: 624 KNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTR 683
Query: 2695 YQSLLRSLSDKLSD----------LDNKLSSSLAVS--------THPDAMNQQLETAQKM 2736
Q L++ ++L +D+++ L V T +A+ Q E A
Sbjct: 684 EQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFR 743
Query: 2737 KQ-----------EIQQEKKQ--------IKVAQALCEDL-SALVKEEYLKAELSRQLEG 2776
K+ I++EK + + AQAL E + + V + +K + S QL
Sbjct: 744 KEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIK-QASEQLNS 802
Query: 2777 ILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPIS-AKLDV 2835
F + + N +++ + A +Q QQ+ + + T E K P + ++
Sbjct: 803 RWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQ-----MTTTAENWLKIQPTTPSEPTA 857
Query: 2836 LESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNK 2895
++S +K KD L+ E+ + +++ LK +G L ++
Sbjct: 858 IKSQLKICKDEVNRLSGLQPQIERL--KIQSIALKEKGQGPMFLDADFVAFTNHFKQVFS 915
Query: 2896 QVKERENKLKESLEKA--LKYKEQVETLWPWIDKCQNNLEEIKFCLDPAE-GENSIAKLK 2952
V+ RE +L+ + ++Y+E + + W+ + + L + + E E + +L+
Sbjct: 916 DVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQ 975
Query: 2953 SLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLE 3012
+LQ + + + L+ T V E+ K+ ++ ++ + + + + L
Sbjct: 976 ALQSSLQEQQSGLYYLSTT------VKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLV 1029
Query: 3013 NMTQKFKEFQEVSKESKRQLQCAKE---QLDIH-----DSLGSQAYSNKYLTMLQTQQKS 3064
QK +E ++ + +Q K+ ++D+ +LG K L +
Sbjct: 1030 EHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSD 1089
Query: 3065 LQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKL 3124
+Q ++ ++ Q + EA + + S + +++ + + + QQV + L+ L
Sbjct: 1090 IQTIQPSLNSVNEGGQKIKNEA-EPEFASRLETELKELNTQWDHMCQQVYARKEALKGGL 1148
Query: 3125 QGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDN 3184
+ Q + EM + ++E + + LQK E +K A +
Sbjct: 1149 EKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKR---------AKEEA 1199
Query: 3185 ANKTCKMMLATEETSPDLV--------GIKRDLEALSKQCNKLLDRAQAREEQVEGTIKR 3236
K K+ L TE + + +K++LE L+ L R + + +E
Sbjct: 1200 QQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWAC 1259
Query: 3237 LEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDV 3296
E S L++ + L + E ++ + E I++ L+ + + + +
Sbjct: 1260 WHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHS----EDNPNQI 1315
Query: 3297 NWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALE 3356
L Q L + + +L+ N+RW+ L+++ +R L++++ Q A E
Sbjct: 1316 RILAQTLTDGGVMD---ELINEELETFNSRWRELHEEAVRRQKLLEQSI------QSAQE 1366
Query: 3357 SLLSWMVDTEELVANQKPPSAEF--KVVKAQI-QEQKLLQRLLDDRKSTVEVIKREGEKI 3413
+ S + E L K +A KV AQ+ QE + +Q L + ++E +K+ +
Sbjct: 1367 TEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGK 1426
Query: 3414 ATTAEPADKVKIL-KQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLT 3472
++ + K+L + ++ A R E + L+ + L
Sbjct: 1427 EAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMI--------LDEVKMHLP 1478
Query: 3473 TIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKD 3532
+E + V E + +Q L + +K+L + + + G+ + E+
Sbjct: 1479 ALETKSVEQEVVQSQ---LNHCVNLYKSLSEV----KSEVEMVIKTGRQIVQKKQTENPK 1531
Query: 3533 MVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSV 3592
+ ++ ++ Y E+ K R + L++ L ++ ++ L WL +L+K S
Sbjct: 1532 ELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSA 1591
Query: 3593 QDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKA 3652
+ L + + + Q++I +K ++ G E LK G + +++DKL + +
Sbjct: 1592 VEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVG-EALKTVLGKKETLVEDKLSLLNS 1650
Query: 3653 RYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQA 3712
+ +T + + L + + + + W+ ++ + L E++ K ++
Sbjct: 1651 NWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWI--IQADTLLDESEKKKPQQKEDV 1708
Query: 3713 QMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQ 3772
K LK E + + +DS + ++ L+ R+ +E ++E N R+ +S I
Sbjct: 1709 L---KRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRI-- 1763
Query: 3773 KVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEI 3832
K + + +QF+ +KL+ + ++Q + K +
Sbjct: 1764 KTGKASIPLKELEQFNSDI-----------QKLLEPLEAEIQQGVNLKEEDFNKDMNED- 1811
Query: 3833 LRHKDIIDDLVKSGHKIMTACSEEEK-QSMKKKLDKVLKNYDTICQINSERYLQLERAQS 3891
++ + +L++ G + ++E K + +K K + ++ + + S+R +
Sbjct: 1812 --NEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISH 1869
Query: 3892 LVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKM 3951
Q+ ++L L + + ++ LP P + R+++E+ E + +++
Sbjct: 1870 QWYQYKRQADDLLKCLDDIEKKLASLPEP-----------RDERKIKEIDRELQKKKEEL 1918
Query: 3952 NKTGPQLLELSP-GEGFSIQEKYVAADTLYSQIKE---DVKKRAVALDEAISQSTQFHDK 4007
N Q LS G +++ + + +I+ ++ A + + T
Sbjct: 1919 NAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMT 1978
Query: 4008 IDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMI 4067
D LE L + +S + ++++ ++ + D E L E+LK + +
Sbjct: 1979 EDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQ 2038
Query: 4068 ARSGGTDKDISAKA-------------VQDKLDQMVFIWENIHTLVEEREAKLLDVMELA 4114
SG D S K +Q+ L Q+ F WE ++ + ++R+ + +E
Sbjct: 2039 QSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKW 2098
Query: 4115 EKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAET---IREEIDGLQEELDI 4171
+F D + + + F+R + P + E A+ ++E DG+ + +
Sbjct: 2099 RRFHYDIKIFNQWLTEAEQFLRKTQIP--------ENWEHAKYKWYLKELQDGIGQRQTV 2150
Query: 4172 VINL---GSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQD 4228
V L G E+I + D I+++ + LN W + K DR +LEE ++Q
Sbjct: 2151 VRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQR 2210
Query: 4229 GLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELL 4288
L W++ A +AS+ + +K+++E++K E +Q +++LN +
Sbjct: 2211 DLNEFVLWLEEADN-IASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPV 2269
Query: 4289 LKKVT---EESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDEL-- 4343
L EE DK +++ L + L W + + +Q ++E + LGQ + L++L
Sbjct: 2270 LVSAPISPEEQDK--LENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEE 2327
Query: 4344 -----LAWLTHTEGLLS--EQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGN 4396
L WL+ L Q G E E+A V A Q VE + G
Sbjct: 2328 QLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIA--------VQAKQPDVEEILSKGQ 2379
Query: 4397 DLIESSAGEEASNLQNKLEVLNQRWQNV-------------------------------- 4424
L + + ++ KLE L+ W+ V
Sbjct: 2380 HLYKEKPATQP--VKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLV 2437
Query: 4425 -----LEKTEQRKQQLDGALR----QAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPET 4475
++T K ++ +L F+ +L WL+ ++ + + + + G E
Sbjct: 2438 TQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLED 2497
Query: 4476 AKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCP-KSAETNIDQDINNLKEKWESVE 4534
E + E + + L+ Q + + + A T I I ++ +W+ V+
Sbjct: 2498 INEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQ 2557
Query: 4535 TKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKV 4594
L R+ +L E L + ++ + ++ L QA L +D + +I E K
Sbjct: 2558 EHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQ 2617
Query: 4595 FANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLD 4654
A ++ + + + L D + + ++ + W + +R+ ER +L+
Sbjct: 2618 LAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALE 2677
Query: 4655 DARKRAKQFHEAWSKLMEWLEESEKSLD------SELEIANDPDKIKTQLAQHKEFQKSL 4708
+ + +QF K + WL E+E + + + + D +K + Q ++ Q +
Sbjct: 2678 ETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEI 2737
Query: 4709 GAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALL 4768
A VY + + + +DD + L L + KW + KS+ ++ LE +
Sbjct: 2738 EAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSD 2797
Query: 4769 FSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRT------ 4822
+ +LQ L+ WL + +L+ P+ GD V D H+AF++EL +
Sbjct: 2798 QWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMST 2857
Query: 4823 -------------SSVQALKRSARELI--EGSRDDSSWVKVQMQELSTRWETVCALSISK 4867
++ L + REL E +++ + ++ Q +E++T WE + S
Sbjct: 2858 LETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADW 2917
Query: 4868 QTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLE 4927
Q +++ L + +E L L +AE + D LID ++ ++K++
Sbjct: 2918 QRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGD------LLIDSLQDHLEKVK 2971
Query: 4928 EKRAEL 4933
R E+
Sbjct: 2972 ALRGEI 2977
Score = 308 bits (789), Expect = 1e-82
Identities = 502/2696 (18%), Positives = 1071/2696 (39%), Gaps = 346/2696 (12%)
Query: 2690 VKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKV 2749
V +YQ+ L + L ++ L + +S + + Q T + ++ + ++
Sbjct: 331 VNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGN 390
Query: 2750 AQALCEDLSALVK-EEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQM 2808
L L K E + E+ Q+ +L S + + A Q Q Q++
Sbjct: 391 ILQLGSKLIGTGKLSEDEETEVQEQMN-LLNSRWECLRVASMEKQSNLHRVLMDLQNQKL 449
Query: 2809 SRDFQAWLDTKKEEQNKS---HPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGE 2865
++ WL TK EE+ + P+ L+ L+ ++ HK + L Q + ++
Sbjct: 450 -KELNDWL-TKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLE-QEQVRVNSLTHMV 506
Query: 2866 NLLLKTQGSEK-AALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPW 2924
++ ++ G AAL+ QL + W + ++R L++ L K + E+ W
Sbjct: 507 VVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAW 566
Query: 2925 IDKCQNNLEEIKFC--LDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEID 2982
+ + ++ + +I D E +S+ KL L+ ++++ + L + LLS +
Sbjct: 567 LSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLST--LK 624
Query: 2983 KEVVTDENKS-----------LIQKVDMVTEQLH----------SKKFCLENMTQKFKEF 3021
+ VT + ++ L+QK++ T Q+ ++ +E +T
Sbjct: 625 NKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTRE 684
Query: 3022 QEVSK-----------ESKRQLQCAKE---QLDIHDSLGSQAYSNKYLTMLQT------- 3060
Q + K + KRQ+ E +LD+ D ++ + +LQ+
Sbjct: 685 QILVKHAQEELPPPPPQKKRQITVDSEIRKRLDV-DITELHSWITRSEAVLQSPEFAIFR 743
Query: 3061 QQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQ--------VETIAQEHSTLSQQ 3112
++ + LK +V+ +R + + D+ ++ L++ ++I Q L+ +
Sbjct: 744 KEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSR 803
Query: 3113 VDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFL 3172
E C L +L + +QN I ++Q + + + + T + IK+ L
Sbjct: 804 WIEFCQLLSERLNWL-EYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQL 862
Query: 3173 K----KLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREE 3228
K ++ L + +A +E + + D A + ++ QARE+
Sbjct: 863 KICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREK 922
Query: 3229 QVEGTIKRLE--EFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEI 3286
+++ L + + +Q++E + E + Q+L + Q
Sbjct: 923 ELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSS-- 980
Query: 3287 EPLQGKQQDVNWLGQGLIQSAAKSTS--TQGLEHDLDDVNARWKTLNKKVAQRAAQLQEA 3344
LQ +Q + +L + + + K+ S ++ + + +++ RWK L+ ++ + +L+E
Sbjct: 981 --LQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQ 1038
Query: 3345 LLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVE 3404
+ + Q+ +++L WM + + + + P + +++K Q+++ +LL + + ++
Sbjct: 1039 MNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLN 1098
Query: 3405 VIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETL 3464
+ G+KI AEP ++ +L L+++W+ + + R L+G + L
Sbjct: 1099 SVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDL 1158
Query: 3465 EPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKV 3524
++EW+T E+ + + +L++ + + K +++ + S+
Sbjct: 1159 SEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIA 1218
Query: 3525 LSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQA-LCNAKIFGEDEVELMNWLNEV 3583
+ ++ ++ +L+ Y + + + + + L++ C ++ E + WLNEV
Sbjct: 1219 QAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLE-KANKWLNEV 1277
Query: 3584 HDKLSKLSVQDYSTEGLWKQQSEL-RVLQEDILLRKQNVDQALLNGLELLKQTTGDEVL- 3641
KL +TE + E+ VL L + + D N + +L QT D +
Sbjct: 1278 EFKLK-------TTENIPGGAEEISEVLDSLENLMRHSEDNP--NQIRILAQTLTDGGVM 1328
Query: 3642 --IIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLH-STH--EELCTWLDK----- 3691
+I ++LE +R++++ + + K LEQ++Q A+ S H +E T++DK
Sbjct: 1329 DELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAY 1388
Query: 3692 ----------------VEVELLSYETQVLK------GEEASQAQM--------------- 3714
++ +L S+E + + G+EA+Q +
Sbjct: 1389 IADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSM 1448
Query: 3715 ------RPKELKKEAKNNKALLD-------------------------------SLNEVS 3737
+P ++ + +K +LD SL+EV
Sbjct: 1449 KFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVK 1508
Query: 3738 SALLELVPWRAREGLEKMVAED----NER-------YRLVSDTITQKVEEIDAAILRSQQ 3786
S + E+V R+ ++K E+ +ER Y + +T++ ++++ + S++
Sbjct: 1509 SEV-EMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRK 1567
Query: 3787 FDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSG 3846
+ + W+ T+ +L + +++ K EI + K + + + G
Sbjct: 1568 MRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVG 1627
Query: 3847 HKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPW 3906
+ T ++E ++ KL + N+ + E L Q + F + + + W
Sbjct: 1628 EALKTVLGKKETL-VEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKW 1686
Query: 3907 LTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEG 3966
+ + +++ E E + QQ+E L+ L AE K++ T Q L G
Sbjct: 1687 IIQADTLLD-------ESEKKKPQQKED-VLKRLKAELNDIRPKVDSTRDQAANLMANRG 1738
Query: 3967 FS----IQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERL 4022
++ + + ++ I +K ++ + + QF+ I ++LE LE +++
Sbjct: 1739 DHCRKLVEPQISELNHRFAAISHRIKTGKASIP--LKELEQFNSDIQKLLEPLEAEIQQ- 1795
Query: 4023 RQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAV 4082
++ + E + ++E+ +V + L QRG+ + R K K
Sbjct: 1796 ----GVNLKEEDFNKDMNEDNEGTV---------KELLQRGDNLQQRITDERKREEIKIK 1842
Query: 4083 QDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPG 4142
Q L + L +R K L++ ++ L+ + D + + L +P
Sbjct: 1843 QQLLQTK---HNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPR 1899
Query: 4143 IDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAW 4202
D +K+ + +EE++ ++ + + L + A EP + + K E+ S +
Sbjct: 1900 -DERKIKEIDRELQKKKEELNAVRRQAE---GLSEDGAAMAVEPTQIQLSKRWREIESKF 1955
Query: 4203 DSLNKAWKDRIDKL-EEAMQAAVQ------------YQDGLQAVFDWVDIAGGKLASMSP 4249
+ +I + EE M + Y + V + L +
Sbjct: 1956 AQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDL 2015
Query: 4250 IGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELK 4309
D E + +Q E LK K Q ++ ++ + L+ T ++ +Q+ L +L
Sbjct: 2016 CAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPV-ERVKLQEALSQLD 2074
Query: 4310 LIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSE-QKPVGGDPKAIE 4368
W+ + + +RQ + + ++ +F + + WLT E L + Q P + +
Sbjct: 2075 FQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYK 2134
Query: 4369 IELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKT 4428
L + LQ+ + Q+ V +N G ++I+ S+ +AS LQ KL LN RWQ V ++
Sbjct: 2135 WYLKE---LQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQL 2191
Query: 4429 EQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLG-GLPETAKEQLNVHMEVC 4487
RK++L+ F ++ + WL + + +AS PL G + KE+L +
Sbjct: 2192 SDRKKRLEEQKNILSEFQRDLNEFVLWLEEADN--IASIPLEPGKEQQLKEKLEQVKLLV 2249
Query: 4488 AAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKE---KWESVETKLNERKTKL 4544
++ K L + G +L P S E D+ N LK+ +W V L E++ ++
Sbjct: 2250 EELPLRQGILKQLNETGGPVLVSAPISPEEQ-DKLENKLKQTNLQWIKVSRALPEKQGEI 2308
Query: 4545 EEALNLAMEFHNSLQDF-------INWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFAN 4597
E + + L+D + WL+ L + ++P+ F + E ++
Sbjct: 2309 EAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPN---QEGPFDVQETEI--- 2362
Query: 4598 EVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGR------ 4651
V + + + E+ G HL + +K +K L + S W K V RL++ R
Sbjct: 2363 AVQAKQPDVEEILSKGQHL--YKEKPATQPVKRKLEDLSSEW-KAVNRLLQELRAKQPDL 2419
Query: 4652 ------------------------------------SLDDARKRAKQFHEAWSKLMEWLE 4675
SL F+ AW++L +WL
Sbjct: 2420 APGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLS 2479
Query: 4676 ESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDN 4735
++ + S+ + D + I + + K + L + + ++LK KTS +
Sbjct: 2480 LLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEAR 2539
Query: 4736 LKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQ 4795
+ D + ++++WD + R+ +L E L S Q+ +A + L + +L +
Sbjct: 2540 TIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWK 2599
Query: 4796 PVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEG-SRDDSSWVKVQMQELS 4854
+D + I K K+L + ++V A +L+ S DD+ V + + ++
Sbjct: 2600 EGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENIN 2659
Query: 4855 TRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRT 4914
W ++ ++ LE R ++F + L WL EAE T VL D R
Sbjct: 2660 ASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTAN---VLQDATRKERL 2716
Query: 4915 LIDQH--KEFMKKLEEKRAELNKATTMGDTV--------LAICHPDSITTIKHWITIIRA 4964
L D KE MK+ ++ + E+ T + + ++ D ++ + +
Sbjct: 2717 LEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNF 2776
Query: 4965 RFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVK 5024
++ E+ + + L ++ L+ LL WLQ + L+ + I + V+
Sbjct: 2777 KWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAP--IGGDFPAVQ 2834
Query: 5025 ALIAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLY 5084
H+ F E+ K+P + +T + I + ++ G ++ LY
Sbjct: 2835 KQNDVHRAFKRELKTKEPVIMSTLETVR------------IFLTEQPLEGLEK-----LY 2877
Query: 5085 PSGSQTQIETKNPRVNLLVSK--------WQQVWLLALERRRKLNDALDRLEELRE 5132
+ E + V L+ K W+++ L + + +RK+++ L+RL+EL+E
Sbjct: 2878 QEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQE 2933
Score = 295 bits (755), Expect = 9e-79
Identities = 474/2585 (18%), Positives = 1053/2585 (40%), Gaps = 294/2585 (11%)
Query: 2574 LEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRK 2633
L ES NL ++QT ++ WL+ E + G +S D ++ Q + + + +
Sbjct: 326 LMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQ 385
Query: 2634 PQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKST 2693
+ + G ++ V+EQ+ + +W+ L ++ + + ++
Sbjct: 386 GRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQ 445
Query: 2694 QYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDA--MNQQLETAQKMKQEIQQEKKQIK--V 2749
+ L+ L+D L+ + + PD + +Q++ + ++++++QE+ ++
Sbjct: 446 NQK--LKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLT 503
Query: 2750 AQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMS 2809
+ D S+ ++ A L QL+ + + ++ + E+ LQ + +
Sbjct: 504 HMVVVVDESS---GDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQ 560
Query: 2810 RDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLL 2869
F AWL K++ NK H KD + +L
Sbjct: 561 CLFSAWLSEKEDAVNKIHTTG---------FKDQNEMLSSL------------------- 592
Query: 2870 KTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWID--- 2926
+ A L+ L KQ + LK+ L LK K + W+D
Sbjct: 593 ----QKLAVLKADLEK--------KKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFA 640
Query: 2927 KCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVV 2986
+C +NL + L+ + + S A + + Q + Q M + T + V +E+
Sbjct: 641 RCWDNLVQ---KLEKSTAQISQA-VTTTQPSLTQTTVMETVTTVTTREQILVKHAQEELP 696
Query: 2987 TDE---------NKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKE 3037
+ + +++D+ +LHS E + Q EF KE KE
Sbjct: 697 PPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQS-PEFAIFRKEG--NFSDLKE 753
Query: 3038 QLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLL 3097
+++ + ++ + LQ +S QAL VE ++G +
Sbjct: 754 KVNAIEREKAEKFRK-----LQDASRSAQAL---------------VEQMVNEG-----V 788
Query: 3098 QVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRD 3157
++I Q L+ + E C L +L + +QN I ++Q + + + +
Sbjct: 789 NADSIKQASEQLNSRWIEFCQLLSERLNWL-EYQNNIIAFYNQLQQLEQMTTTAENWLKI 847
Query: 3158 AETLQKQKETIKAFLK----KLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALS 3213
T + IK+ LK ++ L + +A +E + + D A +
Sbjct: 848 QPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFT 907
Query: 3214 KQCNKLLDRAQAREEQVEGTIKRLE--EFYSKLKEFSILLQKAEEHEESQGPVGMETETI 3271
++ QARE++++ L + + +Q++E + E +
Sbjct: 908 NHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIM 967
Query: 3272 NQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTS--TQGLEHDLDDVNARWKT 3329
Q+L + Q LQ +Q + +L + + + K+ S ++ + + +++ RWK
Sbjct: 968 EQRLGELQALQSS----LQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKK 1023
Query: 3330 LNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQ 3389
L+ ++ + +L+E + + Q+ +++L WM + + + + P + +++K Q+++
Sbjct: 1024 LSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQC 1083
Query: 3390 KLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQ 3449
+LL + + ++ + G+KI AEP ++ +L L+++W+ + + R
Sbjct: 1084 RLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEA 1143
Query: 3450 LEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHN 3509
L+G + L ++EW+T E+ + + +L++ + + K +++
Sbjct: 1144 LKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKE 1203
Query: 3510 KHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQA-LCNAKI 3568
+ S+ + ++ ++ +L+ Y + + + + + L++ C ++
Sbjct: 1204 AKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHEL 1263
Query: 3569 FGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSEL-RVLQEDILLRKQNVDQALLN 3627
E + WLNEV KL +TE + E+ VL L + + D N
Sbjct: 1264 LSYLE-KANKWLNEVEFKLK-------TTENIPGGAEEISEVLDSLENLMRHSEDNP--N 1313
Query: 3628 GLELLKQTTGDEVL---IIQDKLEAIKARYKDITKLSTDVAKTLEQALQLA----RRLHS 3680
+ +L QT D + +I ++LE +R++++ + + K LEQ++Q A + LH
Sbjct: 1314 QIRILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHL 1373
Query: 3681 THEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSAL 3740
E L T++DK +L +Y + +A+Q ++++ + +++ L+ + + +
Sbjct: 1374 IQESL-TFIDK---QLAAY---IADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHN--- 1423
Query: 3741 LELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQ---FDQAADAELSW 3797
+ +E ++++++ D +K++++ Q+ F+Q
Sbjct: 1424 ------QGKEAAQRVLSQ--------IDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMI 1469
Query: 3798 ITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEE 3857
+ E + L +L +EQ+ +QL + K ++ ++K+G +I+ E
Sbjct: 1470 LDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTEN 1529
Query: 3858 KQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQL 3917
+ + +++ + +Y+ + +ER QLE+ L + + L WL T +++
Sbjct: 1530 PKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKR 1589
Query: 3918 PAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAAD 3977
A L + + ++ I + K H+ + + G L + + +++K
Sbjct: 1590 SAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKL---- 1645
Query: 3978 TLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKE 4037
+L + V RA +E ++ ++ ++ ++++ I + + Q ++ E EK K
Sbjct: 1646 SLLNSNWIAVTSRA---EEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKP 1702
Query: 4038 QISEN--KNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWEN 4095
Q E+ K + ++ ++P ++ + + ++A G D K V+ ++ ++ +
Sbjct: 1703 QQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRG----DHCRKLVEPQISELNHRFAA 1758
Query: 4096 IHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAA 4155
I ++ +A + ++ E+F D L+ ++ +L++ + + + +
Sbjct: 1759 ISHRIKTGKASI--PLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTV 1816
Query: 4156 ETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDK 4215
+ + + D LQ+ + E + +K L + ++L R K
Sbjct: 1817 KELLQRGDNLQQRI-------------TDERKREEIKIKQQLLQTKHNALKDLRSQRRKK 1863
Query: 4216 LEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQ 4275
E QY+ + +D KLAS+ P D +K+ EL++ K
Sbjct: 1864 ALEISHQWYQYKRQADDLLKCLDDIEKKLASL-PEPRDERKIKEIDRELQKKKE------ 1916
Query: 4276 IEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIIN-------RQHKL-E 4327
E+ + QAE L +E+ V+ ++L W +E + + H + E
Sbjct: 1917 -ELNAVRRQAEGL----SEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVRE 1971
Query: 4328 GALLALG-----QFQHALDELLAWLTHTEGLLSEQKPVGGDP----KAIEIELAKHHVLQ 4378
++ + + + L +TH L E + + P K E + L+
Sbjct: 1972 ETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLK 2031
Query: 4379 N--DVLAHQS-TVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQL 4435
N D L S ++ ++ ++S+ E LQ L L+ +W+ V + + R+ +
Sbjct: 2032 NIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRF 2091
Query: 4436 DGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPET---AKEQLNVHMEVCAAFEA 4492
D ++ + + FH +I+ QWLT+ E+ L ++ +PE AK + + E+
Sbjct: 2092 DRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQ----IPENWEHAKYKWYL-KELQDGIGQ 2146
Query: 4493 KEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAM 4552
++ ++L G++++ + K+ + + + + +L +W+ V +L++RK +LEE N+
Sbjct: 2147 RQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILS 2206
Query: 4553 EFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKT 4612
EF L +F+ WL +A+ ++ P + ++++ K+ E+ + + +L++T
Sbjct: 2207 EFQRDLNEFVLWLEEADNIASIPLEPGK-EQQLKEKLEQVKLLVEELPLRQGILKQLNET 2265
Query: 4613 G----THLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERG-------RSLDDARKRAK 4661
G ++QD ++N L +W KV + L E+ + L K+ +
Sbjct: 2266 GGPVLVSAPISPEEQD--KLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLE 2323
Query: 4662 QFHEAWSKLMEWLEESEKSLDSELEIANDP------DKIKTQL---AQHKEFQKSLGAKH 4712
E + L+ WL + ++LEI N P D +T++ A+ + ++ L
Sbjct: 2324 DLEEQLNHLLLWL----SPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQ 2379
Query: 4713 SVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWD------TICGKS---------- 4756
+Y T ++ L+ + ++ +L ELR K T G S
Sbjct: 2380 HLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQ 2439
Query: 4757 -----------VERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVM 4805
+E + L + F A L DWL ++ + + + GD++ +
Sbjct: 2440 PVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDIN 2499
Query: 4806 NLIDNHKAFQKELGKRTSSVQALKRSARELIE--GSRDDSSWVKVQMQELSTRWETVCAL 4863
+I KA ++L +R ++ L +A+ L +++ + + +++ + +W+ V
Sbjct: 2500 EMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEH 2559
Query: 4864 SISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFM 4923
+++ +L L+ + ++ + L +A L P DA++ I + K+
Sbjct: 2560 LQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLA 2619
Query: 4924 KKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASA 4983
K L + + ++ A + +L D + H IT E + A + +R++
Sbjct: 2620 KDLRQWQTNVDVANDLALKLLRDYSADDTRKV-HMIT------ENINASWRSIHKRVSER 2672
Query: 4984 LAGLIAKQEL-------LEALLAWLQWAETT---LTDKD-KEVIPQEIEEVKALIAEHQT 5032
A L L LE LAWL AETT L D KE + ++ + VK L+ + Q
Sbjct: 2673 EAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQD 2732
Query: 5033 FMEEM 5037
E+
Sbjct: 2733 LQGEI 2737
Score = 277 bits (708), Expect = 2e-73
Identities = 491/2725 (18%), Positives = 1089/2725 (39%), Gaps = 258/2725 (9%)
Query: 2117 QDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVK 2176
Q L+E+L W+ + E +L+ QG++ + ++D + D+ Q + + +
Sbjct: 337 QTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNILQLGS 396
Query: 2177 KFMETTDPST--ASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQT 2234
K + T S + +Q +M L++R+ E + + + ++L ++L
Sbjct: 397 KLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLH--RVLMDLQNQKLKELND 454
Query: 2235 FLETKTQALT---EVDVPGKDVTELSQYMQESTSEFLEHK---KHLEVLHSLLKEISSHG 2288
+L TKT+ T E + G D+ +L + +Q+ HK + LE + ++
Sbjct: 455 WL-TKTEERTRKMEEEPLGPDLEDLKRQVQQ-------HKVLQEDLEQEQVRVNSLTHMV 506
Query: 2289 LPSDKALVLEKTNNLSKKFKEMEDT----IKEKKEAVTSCQEQLDAFQVLVKS---LKSW 2341
+ D++ T L ++ K + D + ++ Q+ L +Q L + +W
Sbjct: 507 VVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAW 566
Query: 2342 IKETTKKVPIVQPSFGAEDLGKSLEDTKKLQ--------------EKWSLKTPEIQKVNN 2387
+ E V + + G +D + L +KL + +SLK + + N
Sbjct: 567 LSEKEDAVNKIHTT-GFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKN 625
Query: 2388 SGIS------LCNLI----SAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSI 2437
++ L N + V K+ A + AV + + T T +T+
Sbjct: 626 KSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQ--AVTTTQPSLTQTTVMETVTTVTT- 682
Query: 2438 KKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTP 2497
++ + H E+L K ++ ++ + + + W+ + Q+P
Sbjct: 683 -REQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVL----QSP 737
Query: 2498 --APTDTEAVKTQVEQN-KSFEAELKQNVNKVQELKDKLTELLEENPDTP-EAPRWKQML 2553
A E + +++ + E E + K+Q+ L+E+ + A KQ
Sbjct: 738 EFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQAS 797
Query: 2554 TEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPN 2613
+++S+W E QL +R LE NN+ F QL+Q E + + +P
Sbjct: 798 EQLNSRWIEFCQLLSERLNWLEYQ-NNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPT 856
Query: 2614 MLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDS 2673
+ +Q + + + + +PQ E+L L G+ P + A T +
Sbjct: 857 AIKSQLKICKDEVNRLSGLQPQIERLKIQSIA-LKEKGQGPMF---LDADFVAFTNHFKQ 912
Query: 2674 LTGQLSDRCDWIDQAI--VKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLE 2731
+ + R + + +YQ + ++ + + KLS T + M Q+L
Sbjct: 913 VFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLG 972
Query: 2732 TAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENH 2791
Q ++ +Q+++ + +++S E + + + E I +K + + H
Sbjct: 973 ELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSE-ISRKYQSEFEEIEGRWKKLSSQLVEH 1031
Query: 2792 VQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLT 2851
Q L+ + Q + + W+ + P ++L+ +K + +
Sbjct: 1032 CQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQ 1091
Query: 2852 AQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKA 2911
G+ + + + + L+ +L + T WD +QV R+ LK LEK
Sbjct: 1092 TIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKT 1151
Query: 2912 LKYKEQVETLWPWIDKCQNNLEEIKF-CLDPAEGENSIAKLKSLQKEMDQHFGMVELLNN 2970
+ ++ + + W+ + + E F P E + ++ ++K ++E Q V+LL
Sbjct: 1152 VSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTE 1211
Query: 2971 TANSLLSVCE-IDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESK 3029
+ NS+++ + +E + E ++L + +L+ K LE + + E +++
Sbjct: 1212 SVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKAN 1271
Query: 3030 RQLQCAKEQLDIHDSL-GSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASD 3088
+ L + +L +++ G ++ L L+ + + +Q+ + LAQ L
Sbjct: 1272 KWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRI---LAQTLT----- 1323
Query: 3089 SKGTSDVLL--QVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDD 3146
G D L+ ++ET L ++ + LE +Q + ++ + D
Sbjct: 1324 DGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDK 1383
Query: 3147 ELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIK 3206
+L + DA + ++ + I++ L E ++ EE G +
Sbjct: 1384 QLAAYIADKVDAAQMPQEAQKIQSDLTSHE----------------ISLEEMKKHNQGKE 1427
Query: 3207 RDLEALSKQCNKLLDRAQAREEQVEGTIKRLEE---FYSKLKEFSILLQKAEEHEESQGP 3263
LS+ +D AQ + + V + ++ F +L+E ++L + + H +
Sbjct: 1428 AAQRVLSQ-----IDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALET 1482
Query: 3264 VGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDV 3323
+E E + QLN K + ++ + + V G+ ++Q ++ + + L+ + +
Sbjct: 1483 KSVEQEVVQSQLNHCVNLYKS-LSEVKSEVEMVIKTGRQIVQKK-QTENPKELDERVTAL 1540
Query: 3324 NARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVK 3383
+ L KV +R QL++ L + + + L W+ T+ + + +
Sbjct: 1541 KLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLD 1600
Query: 3384 AQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKA 3443
+++ K Q+ ++ +K ++ I GE + T + + + +LSLL+S W A+ ++A
Sbjct: 1601 SEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETL-VEDKLSLLNSNWIAVTSRA 1659
Query: 3444 ETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALED 3503
E L + F + ++ + +W+ + L E Q E+ + + KA +
Sbjct: 1660 EEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQK--EDVLKRLKAELN 1717
Query: 3504 DIINHNKHLHQAVSIGQSLKVLSSRED--KDMVQSKLD-----FSQVWY-IEIQEKSHSR 3555
DI Q+ ++++R D + +V+ ++ F+ + + I+ + S
Sbjct: 1718 DIRPKVDSTRD-----QAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPL 1772
Query: 3556 SELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQ------QSELRV 3609
EL Q K+ E E+ +N + +K +D EG K+ + R+
Sbjct: 1773 KELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNED--NEGTVKELLQRGDNLQQRI 1830
Query: 3610 LQE---DILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAK 3666
E + + KQ + Q N L+ L+ + L I + K + D+ K D+ K
Sbjct: 1831 TDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEK 1890
Query: 3667 TLEQALQLA--RRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQA-QMRPKELKKEA 3723
L + R++ EL K E+ + + + L + A+ A + +L K
Sbjct: 1891 KLASLPEPRDERKIKEIDRELQK--KKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRW 1948
Query: 3724 KNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNE-RYRLVSDTITQKVEEIDAAIL 3782
+ ++ ++ A + V RE ++ ED V T ++ + A+L
Sbjct: 1949 REIESKFAQFRRLNFAQIHTV----REETMMVMTEDMPLEISYVPSTYLTEITHVSQALL 2004
Query: 3783 RSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDL 3842
+Q A D + K+ SL +I+ Q+S ++ + + L+ ++ +
Sbjct: 2005 EVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERV 2064
Query: 3843 VKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEE 3902
K+ A S+ + Q +K++K+ K+ + E++ + + NQ
Sbjct: 2065 -----KLQEALSQLDFQW--EKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQ------- 2110
Query: 3903 LWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELS 3962
WLTE + + + P E + + ++L++ I + + + +N TG ++++ S
Sbjct: 2111 ---WLTEAEQFLRKTQIP--ENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQS 2165
Query: 3963 PGEGFSI-QEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVER 4021
SI QEK + + + ++ + + R L+E + ++F +++ + LE +
Sbjct: 2166 SKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEE-ADN 2224
Query: 4022 LRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKA 4081
+ P + +++KE++ + K + ++ Q + + L + G ++ + + ++
Sbjct: 2225 IASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEE--QDK 2282
Query: 4082 VQDKLDQMVFIWENIHTLVEER----EAKLLDVMELAEKF-----WCDHMSLIVTIKDTQ 4132
+++KL Q W + + E+ EA++ D+ +L +K +H L++ + +
Sbjct: 2283 LENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNH--LLLWLSPIR 2340
Query: 4133 DFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVK 4192
+ + P + Q+ E A + Q +++ +++ G L +P VK
Sbjct: 2341 NQLEIYNQPNQEGPFDVQETEIA------VQAKQPDVEEILSKGQHLYKE--KPATQPVK 2392
Query: 4193 KSIDELNSAWDSLNKAWKD-----------------------------------RIDKLE 4217
+ +++L+S W ++N+ ++ I KLE
Sbjct: 2393 RKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLE 2452
Query: 4218 EA------MQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEA 4271
+ A + + DW+ + + S + DLE + + I + K +
Sbjct: 2453 MPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDL 2512
Query: 4272 YQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALL 4331
Q++ ++E L A+ L K + + + + D + ++ WD ++E + NR+ +L L
Sbjct: 2513 EQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLK 2572
Query: 4332 ALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAV 4391
Q+ A +E L L K AI+ ++ + L D+ Q+ V+
Sbjct: 2573 DSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVA 2632
Query: 4392 NKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIED 4451
N L+ + ++ + E +N W+++ ++ +R+ L+ R + F ++E
Sbjct: 2633 NDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEK 2692
Query: 4452 LQQWLTDTE------RHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQ 4505
WLT+ E + + L + KE + ++ EA + Y +L + Q
Sbjct: 2693 FLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQ 2752
Query: 4506 QMLARCPKSAE-TNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINW 4564
++L S + + + ++N+ KW + K ++ LE + + H SLQ+ + W
Sbjct: 2753 KILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVW 2812
Query: 4565 LTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQD 4624
L + L+ + V Q D H+ F E+ + I+ +T ++ F +Q
Sbjct: 2813 LQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLET---VRIFLTEQP 2869
Query: 4625 VVLIKNLL-----ISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKL----MEWLE 4675
+ ++ L + + R + V + L RK+A++ + W KL +W
Sbjct: 2870 LEGLEKLYQEPRELPPEERAQNVTRLL----------RKQAEEVNTEWEKLNLHSADWQR 2919
Query: 4676 ESEKSLDSELEIANDPDKIKTQLAQ 4700
+ +++L+ E+ D++ +L Q
Sbjct: 2920 KIDETLERLQELQEATDELDLKLRQ 2944
Score = 226 bits (576), Expect = 5e-58
Identities = 345/1758 (19%), Positives = 713/1758 (40%), Gaps = 172/1758 (9%)
Query: 3339 AQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDD 3398
+ L E+ ++ R+Q ALE +LSW++ E+ + Q S + +VVK Q + L
Sbjct: 324 SSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTA 383
Query: 3399 RKSTVEVIKREGEKIATTAEPA--DKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVV 3456
+ V I + G K+ T + + ++ ++ +Q++LL+SRWE L + + L + +
Sbjct: 384 HQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMD 443
Query: 3457 AQQFHETLEPLNEWLTTIEKRL--VNCEPIGTQASKLEEQIAQHKALEDDI----INHNK 3510
Q ++ L+ LN+WLT E+R + EP+G L+ Q+ QHK L++D+ + N
Sbjct: 444 LQ--NQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNS 501
Query: 3511 HLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFG 3570
H V + +S S ++ +L + I + R LLQ L +
Sbjct: 502 LTHMVVVVDES----SGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLT 557
Query: 3571 EDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLE 3630
E++ WL+E D ++K+ T G Q L LQ+ +L+ LE
Sbjct: 558 EEQCLFSAWLSEKEDAVNKI-----HTTGFKDQNEMLSSLQKLAVLKAD---------LE 603
Query: 3631 LLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLD 3690
KQ+ G + QD L +K + S ++ WLD
Sbjct: 604 KKKQSMGKLYSLKQDLLSTLKNK--------------------------SVTQKTEAWLD 637
Query: 3691 KVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRARE 3750
++ V K E+++ + + + +++++ V++ LV A+E
Sbjct: 638 NF---ARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTREQILVK-HAQE 693
Query: 3751 GLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGD 3810
L ++ ++ D+ +K ++D L SWIT +E L S
Sbjct: 694 ELPP--PPPQKKRQITVDSEIRKRLDVDITELH------------SWITRSEAVLQSPEF 739
Query: 3811 IRLEQDQTSAQLQVQKTFTMEILRHKDI--IDDLVKSGHKIMTACSEE--EKQSMKKKLD 3866
++ + L+ +K +E + + + D +S ++ E S+K+ +
Sbjct: 740 AIFRKEGNFSDLK-EKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASE 798
Query: 3867 KVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYET 3926
++ + CQ+ SER LE +++ F+ ++L T ++ + P E
Sbjct: 799 QLNSRWIEFCQLLSERLNWLEYQNNII-AFYNQLQQLEQMTTTAENWLKIQPTTPSEPTA 857
Query: 3927 LRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKED 3986
++ Q + + ++ +P I+++ L E G F + +VA + Q+ D
Sbjct: 858 IKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMF-LDADFVAFTNHFKQVFSD 916
Query: 3987 VKKRAVALDEAIS--QSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKN 4044
V+ R L ++ + + I +++ +L P + E +++++ E +
Sbjct: 917 VQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQA 976
Query: 4045 VSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEERE 4104
+ +++ Q L +EM S +IS K Q + +++ W+ + + + E
Sbjct: 977 LQSSLQEQQSGLYYLSTTVKEM---SKKAPSEISRK-YQSEFEEIEGRWKKLSSQLVEHC 1032
Query: 4105 AKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGI-DPSVVKQQQEAAETIREEID 4163
KL + M K +L + + F+++ E P + D ++K+Q + + +I
Sbjct: 1033 QKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKE-EWPALGDSEILKKQLKQCRLLVSDIQ 1091
Query: 4164 GLQEELDIVINLGSELIAACGEPD-KPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQA 4222
+Q L+ V N G + I EP+ ++ + ELN+ WD + + R + L+ ++
Sbjct: 1092 TIQPSLNSV-NEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEK 1150
Query: 4223 AVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLN 4282
V Q L + +W+ A + + +++ +EE+K+ K EA Q++ +++ L
Sbjct: 1151 TVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLT 1210
Query: 4283 HQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDE 4342
++ + + + ++ L L + L R+ + LE + L++
Sbjct: 1211 ESVNSVIAQAPPVA-QEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEK 1269
Query: 4343 LLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESS 4402
WL E L + + G + I L L+N + + + L +
Sbjct: 1270 ANKWLNEVEFKLKTTENIPGGAEEISEVLDS---LENLMRHSEDNPNQIRILAQTLTDGG 1326
Query: 4403 AGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERH 4462
+E N +LE N RW+ + E+ +R++ L+ +++ A+ + +Q+ LT ++
Sbjct: 1327 VMDELIN--EELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQ 1384
Query: 4463 LLA----SKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETN 4518
L A +P+ A++ + ++ + + EE M+K Q K A
Sbjct: 1385 LAAYIADKVDAAQMPQEAQK---IQSDLTSHEISLEE-----MKKHNQ-----GKEAAQR 1431
Query: 4519 IDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRP 4578
+ I+ ++K + V K F LQ+ L + + L
Sbjct: 1432 VLSQIDVAQKKLQDVSMKF--------RLFQKPANFEQRLQESKMILDEVKMHLPALETK 1483
Query: 4579 SLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSR 4638
S+ + V Q++ ++ + ++ + KTG + Q ++ + + +++
Sbjct: 1484 SVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLH 1543
Query: 4639 WEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQL 4698
+ ++ ++ ER + L+ K +++ + + L EWL ++ L + P + +++
Sbjct: 1544 YNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEV 1603
Query: 4699 AQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVE 4758
A K QK + + + G +L KT L ++D LS L W + ++ E
Sbjct: 1604 AWGKATQKEIEKQKVHLKSITEVGEAL--KTVLGKKETLVEDKLSLLNSNWIAVTSRAEE 1661
Query: 4759 RQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKEL 4818
N L E F + + W+ + + L E + D K + EL
Sbjct: 1662 WLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEK-----KKPQQKEDVLKRLKAEL 1716
Query: 4819 GKRTSSVQALKRSARELIEGSRDD-SSWVKVQMQELSTRWETVCALSISKQTRLEAALRQ 4877
V + + A L+ D V+ Q+ EL+ R+ + K + L++
Sbjct: 1717 NDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAIS--HRIKTGKASIPLKE 1774
Query: 4878 AEEFHSVVHALLEWL-AEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKA 4936
E+F+S + LLE L AE +Q GV +ED + + + ++ +K+L ++ L +
Sbjct: 1775 LEQFNSDIQKLLEPLEAEIQQ-----GVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQR 1829
Query: 4937 TTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIA--KQELL 4994
T R E + +Q Q +AL L + +++ L
Sbjct: 1830 IT------------------------DERKREEIKIKQQLLQTKHNALKDLRSQRRKKAL 1865
Query: 4995 EALLAWLQWAETT------LTDKDKEVI----PQEIEEVKALIAEHQTFMEEMTRKQPDV 5044
E W Q+ L D +K++ P++ ++K + E Q EE+ +
Sbjct: 1866 EISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQA 1925
Query: 5045 DKVTKTYKRRAADPSSLQ 5062
+ +++ A +P+ +Q
Sbjct: 1926 EGLSEDGAAMAVEPTQIQ 1943
Score = 221 bits (563), Expect = 2e-56
Identities = 112/231 (48%), Positives = 153/231 (66%), Gaps = 5/231 (2%)
Query: 71 DERDKVQKKTFTKWINQHLMKVRK-HVNDLYEDLRDGHNLISLLEVLSGDTLPREKGRMR 129
DER+ VQKKTFTKW+N K K H+ +L+ DL+DG L+ LLE L+G LP+EKG R
Sbjct: 3 DEREDVQKKTFTKWVNAQFSKFGKQHIENLFSDLQDGRRLLDLLEGLTGQKLPKEKGSTR 62
Query: 130 FHRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDI--HVTGE 187
H L NV AL L+ V LVNI + DI DGN KLTLGLIW IILH+Q+ ++ ++
Sbjct: 63 VHALNNVNKALRVLQNNNVDLVNIGSTDIVDGNHKLTLGLIWNIILHWQVKNVMKNIMAG 122
Query: 188 SEDMSAKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAV-Q 246
+ ++++ LL W +Q+T Y + NFTT W DG NA+IH +RPDL D N+V Q
Sbjct: 123 LQQTNSEKILLSWVRQSTRNYPQVNVINFTTSWSDGLALNALIHSHRPDLFDWNSVVCQQ 182
Query: 247 SNLANLEHAFYVAE-KIGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAFPK 296
S LEHAF +A ++G+ +LLDPEDVD + PD+KS++ Y++SL+ P+
Sbjct: 183 SATQRLEHAFNIARYQLGIEKLLDPEDVDTTYPDKKSILMYITSLFQVLPQ 233
Score = 205 bits (521), Expect = 1e-51
Identities = 284/1564 (18%), Positives = 642/1564 (41%), Gaps = 148/1564 (9%)
Query: 3506 INHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCN 3565
++H H Q +++ + + K +S ++Q Y+ + + S
Sbjct: 260 LHHQMHYSQQITVSLAQGYERTSSPKPRFKSYA-YTQAAYVTTSDPTRSPFPSQHLEAPE 318
Query: 3566 AKIFG----EDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQE--------- 3612
K FG E EV L + + + LS L + + + + +++ V+++
Sbjct: 319 DKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYM 378
Query: 3613 -DILLRKQNVDQALLNGLELLK--QTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLE 3669
D+ + V L G +L+ + + DE +Q+++ + +R++ + S + L
Sbjct: 379 MDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLH 438
Query: 3670 QALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKG--EEASQAQMRPKELKKEAKNNK 3727
+ L + + +EL WL K E E + L E+ + + K L+++ + +
Sbjct: 439 RVLMDLQ--NQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQ 496
Query: 3728 ALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQF 3787
++SL + + E A LE+ + +R+ + + + +L+ Q+
Sbjct: 497 VRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRL 556
Query: 3788 DQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGH 3847
+ +W++E E V K T +++ L K
Sbjct: 557 TEEQCLFSAWLSEKEDA-------------------VNKIHTTGFKDQNEMLSSLQKLA- 596
Query: 3848 KIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWL 3907
++ A E++KQSM K LK D + + ++ Q + ++ ++ F ++ L L
Sbjct: 597 -VLKADLEKKKQSMGKLYS--LKQ-DLLSTLKNKSVTQ--KTEAWLDNFARCWDNLVQKL 650
Query: 3908 TETQSIISQLPA---PALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPG 3964
++ + ISQ P+L T+ + +++ +H +++ PQ
Sbjct: 651 EKSTAQISQAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQ--EELPPPPPQ------- 701
Query: 3965 EGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQ 4024
+++ + D+ +++KR LD I++ + + + +L+S E + R
Sbjct: 702 -----KKRQITVDS-------EIRKR---LDVDITELHSWITRSEAVLQSPEFAIFRKE- 745
Query: 4025 PPSISAEVEKIKEQISENKNVSVD-MEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQ 4083
+KE+++ + + KLQ + + E+M+ ++ ++A +++
Sbjct: 746 -----GNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMV------NEGVNADSIK 794
Query: 4084 DKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGI 4143
+Q+ W L+ ER L+ F+ L +++++
Sbjct: 795 QASEQLNSRWIEFCQLLSER-LNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPS 853
Query: 4144 DPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWD 4203
+P+ +K Q + + + GLQ +++ L + IA + P+ +D A+
Sbjct: 854 EPTAIKSQLKICKDEVNRLSGLQPQIE---RLKIQSIALKEKGQGPMF---LDADFVAFT 907
Query: 4204 SLNKAWKDRIDKLEEAMQAA------VQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETV 4257
+ K + E+ +Q ++YQ+ + A+ WV + KL+ TD E +
Sbjct: 908 NHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIM 967
Query: 4258 KQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEE 4317
+Q++ EL+ +S +QQ + L+ + + KK E + Q E++ W L
Sbjct: 968 EQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRK-YQSEFEEIEGRWKKLSS 1026
Query: 4318 RIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVL 4377
+++ KLE + L + Q+ + L W+ + L E+ P GD + ++ +L + +L
Sbjct: 1027 QLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLL 1086
Query: 4378 QNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDG 4437
+D+ Q ++ +VN+ G + + E AS L+ +L+ LN +W ++ ++ RK+ L G
Sbjct: 1087 VSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKG 1146
Query: 4438 ALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETY 4497
L + ++ ++ +W+T E L P+ ++ + + KE
Sbjct: 1147 GLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKV 1206
Query: 4498 KSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNS 4557
K L + ++A+ P A+ + +++ L ++ + T+LN + LEE E +
Sbjct: 1207 KLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSY 1266
Query: 4558 LQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLK 4617
L+ WL + E L + + +D + + QI L +T T
Sbjct: 1267 LEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTDGG 1326
Query: 4618 YFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEES 4677
+ LI L + SRW ++ + V R + L+ + + A++ ++ + E L
Sbjct: 1327 VMDE-----LINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFI 1381
Query: 4678 EKSLDSEL-------EIANDPDKIKTQLAQH----KEFQKSLGAKHSVYDTTNRTGRSLK 4726
+K L + + ++ + KI++ L H +E +K K + ++ + K
Sbjct: 1382 DKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQK 1441
Query: 4727 EKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYR 4786
KL D+ + R + K + +L+E+ + + L AL
Sbjct: 1442 ----------KLQDVSMKFR-----LFQKPANFEQRLQESKMILDEVKMHLPAL------ 1480
Query: 4787 VEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSR-DDSSW 4845
E + E + V ++ +NL K L + S V+ + ++ R++++ + ++
Sbjct: 1481 -ETKSVEQEVVQSQLNHCVNL-------YKSLSEVKSEVEMVIKTGRQIVQKKQTENPKE 1532
Query: 4846 VKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVL 4905
+ ++ L + + A ++ +LE L+ + + ++ L EWLA + L +
Sbjct: 1533 LDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAV 1592
Query: 4906 PDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRAR 4965
L + + K K++E+++ L T +G+ + + T ++ ++++ +
Sbjct: 1593 EGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKE-TLVEDKLSLLNSN 1651
Query: 4966 FEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKA 5025
+ V + A++ L + + ++ + W+ A+T L + +K+ Q+ + +K
Sbjct: 1652 WIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKR 1711
Query: 5026 LIAE 5029
L AE
Sbjct: 1712 LKAE 1715
Score = 184 bits (467), Expect = 2e-45
Identities = 494/2698 (18%), Positives = 1056/2698 (39%), Gaps = 384/2698 (14%)
Query: 1210 KLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVF 1269
KLK +N L T+ T+ EEE + D +++ + K + ++++++
Sbjct: 448 KLKELNDWLTKTEE--------RTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRV 499
Query: 1270 HALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIG 1329
++L + + DE + L+ E+ L +RW N+ ++R L+ I
Sbjct: 500 NSLTHMV----VVVDESSGDHATAALE-----EQLKVLGDRWANICRWTEDRWVLLQDI- 549
Query: 1330 KSLKYYRDTYHP--LDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSK 1387
LK+ R T W+ + E KI ++ + + L + +L +++E K+
Sbjct: 550 -LLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQS 608
Query: 1388 MDECQKYAEQYSATVKDYELQTMT------YRAMVDSQQKSPVKRRRMQSSADLIIQEFM 1441
M + + +T+K+ + T + D+ + K S A Q +
Sbjct: 609 MGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSL 668
Query: 1442 DLRTRYTALVTLMTQ---YIKFAGDSLKRLEEEEK---SLEEEKKEHVE-KAKELQKWVS 1494
T + T+ T+ +K A + L ++K +++ E ++ ++ EL W++
Sbjct: 669 TQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWIT 728
Query: 1495 NISKTLKDAE-----KAGKPPFSKQKISS--EEISTKKEQLSEALQTIQLFLAKHGD--- 1544
L+ E K G K+K+++ E + K +L +A ++ Q + + +
Sbjct: 729 RSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGV 788
Query: 1545 -----KMTDEERNE--------LEKQVKTLQESYNLL-FSESLKQLQESQTSGD--VKV- 1587
K E+ N L +++ L+ N++ F L+QL++ T+ + +K+
Sbjct: 789 NADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQ 848
Query: 1588 -----EEKIVAERQQEYKEKLQGICDLLTQTENRLI--------GHQEAFMIGDGTVELK 1634
E + + + K+++ + L Q E I G F+ D
Sbjct: 849 PTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTN 908
Query: 1635 KY-------QSKQEELQKDM--------QGSAQALAEVVKNTENFLKENGEKLSQEDKAL 1679
+ Q++++ELQ Q + A+ V+ +E K + +LS D +
Sbjct: 909 HFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSET--KLSIPQLSVTDYEI 966
Query: 1680 IEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDW 1739
+EQ+L E ++ Q +L+ +QS ++T +KE ++K + E K ++ +
Sbjct: 967 MEQRLGE--LQALQSSLQEQQSGLYY---LSTTVKEMSKKAPS-----EISRKYQSEFEE 1016
Query: 1740 LSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQEN 1799
+ K +H Q +E+ Q + + + E DV +
Sbjct: 1017 IEGRWKKLSSQLVEHCQKLEE-----QMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALG 1071
Query: 1800 LNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYE 1859
++ +K Q ++S Q + + S +K PE +L+ +KEL ++
Sbjct: 1072 DSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWD 1131
Query: 1860 TALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKR 1919
+ + + E+ D +E W+ Q+E+E + + L ++
Sbjct: 1132 HMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEE 1191
Query: 1920 QKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRF 1979
K E+ + ++ +T S N V+ A ++ ++++L+ T +
Sbjct: 1192 MKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQ------------EALKKELETLTTNY 1239
Query: 1980 RSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQ 2039
+ L C L K L + + + + LL+ L+ A+K L+E ++ +
Sbjct: 1240 QWL---CTRLNGKCKTLEEVWACWHE----LLSYLE----KANKWLNE--------VEFK 1280
Query: 2040 LEETKALQG---QISSQQVAVEKLKKTAEVLLDARGSLLPAKND-------IQKTLDDIV 2089
L+ T+ + G +IS ++E L + +E + L D I + L+
Sbjct: 1281 LKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTDGGVMDELINEELETFN 1340
Query: 2090 GRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLK-------EQGQVPL 2142
R+ +L + R + L+ ++ + + L + + + ++ L + Q+P
Sbjct: 1341 SRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQ 1400
Query: 2143 NSTALQ-DIISKNIMLEQ---DIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLS 2198
+ +Q D+ S I LE+ G++++ +++ + D S L K +
Sbjct: 1401 EAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFE 1460
Query: 2199 ARFSEASHKHKETLAKMEELKTK--------------VELFENLSE---KLQTFLETKTQ 2241
R E+ E + L+TK V L+++LSE +++ ++T Q
Sbjct: 1461 QRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQ 1520
Query: 2242 ALTEVDVP-------------------GKDVTELSQYMQESTSEFLEHKKHLEVL----- 2277
+ + G VTE Q +++ + +K + VL
Sbjct: 1521 IVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLA 1580
Query: 2278 ---HSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVL 2334
L K + G+PS+ + K+ ++ + +K E + + L + L
Sbjct: 1581 ATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETL 1640
Query: 2335 VKSLKS-----WIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSG 2389
V+ S WI T++ AE+ L + +K E + I K
Sbjct: 1641 VEDKLSLLNSNWIAVTSR----------AEEWLNLLLEYQKHMETFDQNVDHITKWIIQA 1690
Query: 2390 ISLCNLISAVTTPAKAIAAVKSGGAVLNG-----EGTATNTEEFWANKGLTSIKKDMTDI 2444
+L + S P + +K A LN + T AN+G
Sbjct: 1691 DTLLD-ESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRG----------- 1738
Query: 2445 SHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEA 2504
+ L++ +I+ELN + + + + A + L+++ + + Q+ P + E
Sbjct: 1739 ----DHCRKLVEPQISELNHRFAAISHRIKTGKASIP-LKELEQFNSDIQKLLEPLEAEI 1793
Query: 2505 VKTQVEQNKSFEAELKQ-NVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQEL 2563
+ + + F ++ + N V+EL + L + D + K + +K L
Sbjct: 1794 QQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNAL 1853
Query: 2564 NQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQ 2623
L R++K E S+ Q++ L + L + E ++ L P D + +++Q
Sbjct: 1854 KDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASL-PEPRDERKIKEIDRELQ 1912
Query: 2624 ILLQEFATRKPQYEQLTAAGQGILSRP-------------GEDPSLRGIVKEQLAAVTQK 2670
+E + Q E L+ G + P + R + Q+ V ++
Sbjct: 1913 KKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREE 1972
Query: 2671 WDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQL 2730
T + ++ + V ST Y + + +S L +++ L++ + + + +Q
Sbjct: 1973 ----TMMVMTEDMPLEISYVPST-YLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQE 2027
Query: 2731 ETAQKMKQEIQQEKKQIKVAQALCEDLSAL--------VKEEYLKAELSRQLEGILKSFK 2782
E+ + +K +QQ +I + + + +AL VK + ++L Q E + K +K
Sbjct: 2028 ESLKNIKDSLQQSSGRIDIIHS--KKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYK 2085
Query: 2783 DVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSH-PISAKLDVLESLIK 2841
D + + + V+ + F Q + + +L + +N H L L+ I
Sbjct: 2086 DRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKELQDGIG 2145
Query: 2842 DHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERE 2901
+ +TL A GE ++ ++ ++ + LQ +L ++ W KQ+ +R+
Sbjct: 2146 QRQTVVRTLN----------ATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRK 2195
Query: 2902 NKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGE---NSIAKLKSLQKEM 2958
+L+E +++ + W+++ +N+ I L+P + + + ++K L +E+
Sbjct: 2196 KRLEEQKNILSEFQRDLNEFVLWLEEA-DNIASIP--LEPGKEQQLKEKLEQVKLLVEEL 2252
Query: 2959 DQHFGMVELLNNTANSLLSVCEIDKEVVTD-ENK-------------------------- 2991
G+++ LN T +L I E ENK
Sbjct: 2253 PLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQI 2312
Query: 2992 ----SLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKE-----SKRQLQCAKEQLDIH 3042
L +K++ + EQL+ L + + + + + ++E + ++ +Q D+
Sbjct: 2313 KDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVE 2372
Query: 3043 DSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASD---------SKGTS 3093
+ L + K Q ++ L+ L + RL Q+L + D + T
Sbjct: 2373 EILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQ 2432
Query: 3094 DVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAP 3153
V L + + + + +S+ E S L ++ + F E+ + D + S
Sbjct: 2433 TVTLVTQPVVTKETAISKL--EMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRV 2490
Query: 3154 VGRDAETLQ----KQKETIKAFLKK---LEALMASNDN-ANKTCKMMLATEETSPDLVGI 3205
+ D E + KQK T++ ++ LE L+ + N NKT T T
Sbjct: 2491 MVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITD------ 2544
Query: 3206 KRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVG 3265
+E + Q +++ + Q R +Q+ +K ++ +E +L +A ES
Sbjct: 2545 --RIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGP 2602
Query: 3266 METETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNA 3325
+ I +++ K K ++ Q N L L++ + + T+ + +++NA
Sbjct: 2603 YTVDAIQKKITETKQLAK-DLRQWQTNVDVANDLALKLLRDYS-ADDTRKVHMITENINA 2660
Query: 3326 RWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELV-----ANQKPPSAE-F 3379
W++++K+V++R A L+E +F LE L+W+ + E A +K E
Sbjct: 2661 SWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDS 2720
Query: 3380 KVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKIL-KQLSLLDSRWEA 3438
K VK +++ + LQ ++ + +KI + E +D +L ++L ++ +W
Sbjct: 2721 KGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSE 2780
Query: 3439 LLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQH 3498
L K+ LE S ++ H +L+ L WL + L PIG +++Q H
Sbjct: 2781 LRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVH 2840
Query: 3499 KALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSEL 3558
+A + ++ + +S +++++ + + + ++ + + + +E++ + + L
Sbjct: 2841 RAFKRELKTKEPVI---MSTLETVRIFLTEQPLEGLEKL--YQEPRELPPEERAQNVTRL 2895
Query: 3559 LQQALCNAKIFGED-EVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLR 3617
L++ E + +W ++ + L +L +T+ L +L++ Q +++
Sbjct: 2896 LRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDEL-----DLKLRQAEVIKG 2950
Query: 3618 K-QNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQL 3674
Q V L++ L QD LE +KA +I L +V+ + A QL
Sbjct: 2951 SWQPVGDLLIDSL--------------QDHLEKVKALRGEIAPLKENVSHVNDLARQL 2994
Score = 38.9 bits (89), Expect = 0.14
Identities = 46/168 (27%), Positives = 73/168 (43%), Gaps = 27/168 (16%)
Query: 648 VQDLLNWVDEMQVQLDR-TEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMT 706
+Q+LL W+ +L R G D P+V+ +VHRA + E KE I T
Sbjct: 2806 LQELLVWLQLKDDELSRQAPIGGDFPAVQKQ----NDVHRAFKR-ELKTKEPVIMSTLET 2860
Query: 707 APLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYD 766
+ LT + L LE Y + R L RA N + L K+ EEV +
Sbjct: 2861 VRIFLT-EQPLEGLEKLY--------QEPRELPP----EERAQN-VTRLLRKQAEEVNTE 2906
Query: 767 WSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARL 814
W + N + A+ R++D+ E ++ +QE ++L L+ A +
Sbjct: 2907 WEKLNL-------HSADWQRKIDETLERLQELQEATDELDLKLRQAEV 2947
>gi|5032315 dystrophin Dp427p2 isoform [Homo sapiens]
Length = 3562
Score = 325 bits (832), Expect = 1e-87
Identities = 545/2835 (19%), Positives = 1126/2835 (39%), Gaps = 316/2835 (11%)
Query: 2230 EKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHL-----------EVLH 2278
++ QT LE L + + E+S ++ +F H+ ++ +L
Sbjct: 219 DRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNILQ 278
Query: 2279 SLLKEISSHGLPSDKAL-VLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKS 2337
K I + L D+ V E+ N L+ +++ + EK+ + + +D +K
Sbjct: 279 LGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLH--RVLMDLQNQKLKE 336
Query: 2338 LKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLIS 2397
L W+ +T ++ ++ E LG LED K+ ++ + ++++ SL +++
Sbjct: 337 LNDWLTKTEERTRKMEE----EPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVV 392
Query: 2398 AVTTPA--KAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLL 2455
V + A AA++ VL WAN I ED +LL
Sbjct: 393 VVDESSGDHATAALEEQLKVLGDR---------WAN------------ICRWTEDRWVLL 431
Query: 2456 KDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSF 2515
+D L K Q+ EE WL + K T E + + +++
Sbjct: 432 QDI-------LLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSS-LQKLAVL 483
Query: 2516 EAEL---KQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEI-DSKWQELNQLTIDRQ 2571
+A+L KQ++ K+ LK L L+ T + W D+ Q+L + T
Sbjct: 484 KADLEKKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQIS 543
Query: 2572 QKLEESSNNLTQFQTVEA------------------------------------------ 2589
Q + + +LTQ +E
Sbjct: 544 QAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDV 603
Query: 2590 ---QLKQWLVEKELMV-SVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQG 2645
+L W+ E ++ S + + +++V + +E A + + + + + Q
Sbjct: 604 DITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQA 663
Query: 2646 ILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDK 2705
++ + + +K+ + +W LS+R +W++ + + L+ L
Sbjct: 664 LVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQN-NIIAFYNQLQQLEQM 722
Query: 2706 LSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEE- 2764
+ +N L + P A+ QL+ + + + QI+ + S +KE+
Sbjct: 723 TTTAENWLKIQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQ----SIALKEKG 778
Query: 2765 ----YLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKK 2820
+L A+ + F DV+ + E +Q + ++Q+ + W+ +
Sbjct: 779 QGPMFLDADFVAFTNHFKQVFSDVQAR-EKELQTIFDTLPPM-RYQETMSAIRTWVQQSE 836
Query: 2821 EEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQ 2880
+ + +++E + + + +L Q + + K Q
Sbjct: 837 TKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQ 896
Query: 2881 LQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLD 2940
+ I+ W + Q+ E KL+E + K K + ++TL W+ + L+E
Sbjct: 897 SEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEW---- 952
Query: 2941 PAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTD-----------E 2989
PA G++ I L+K++ Q +V + SL SV E +++ + E
Sbjct: 953 PALGDSEI-----LKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETE 1007
Query: 2990 NKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQA 3049
K L + D + +Q++++K L+ +K Q+ E + A+E+ D
Sbjct: 1008 LKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERD------ 1061
Query: 3050 YSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTL 3109
+ K LQ + ++ K + K L+ E+ +S + E + +E TL
Sbjct: 1062 FEYKTPDELQKAVEEMKRAKEEAQ-QKEAKVKLLTESVNSVIAQAPPVAQEALKKELETL 1120
Query: 3110 SQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIK 3169
+ C+ L K + + E+ S + + L+ + + E + E I
Sbjct: 1121 TTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEIS 1180
Query: 3170 AFLKKLEALMA-SNDNANKTCKMMLATEETSPDLVG--IKRDLEALSKQCNKLLDRAQAR 3226
L LE LM S DN N+ +LA T ++ I +LE + + +L + A R
Sbjct: 1181 EVLDSLENLMRHSEDNPNQI--RILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRR 1238
Query: 3227 EEQVEGTIKRLEEFYSKL---KEFSILLQK------AEEHEESQGPVGMETETINQQLNM 3277
++ +E +I+ +E L +E + K A++ + +Q P E + I L
Sbjct: 1239 QKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMP--QEAQKIQSDLTS 1296
Query: 3278 FKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQR 3337
++ +E + QGK+ L Q I A K L DV+ +++ L +K A
Sbjct: 1297 HEISLEEMKKHNQGKEAAQRVLSQ--IDVAQKK---------LQDVSMKFR-LFQKPANF 1344
Query: 3338 AAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLD 3397
+LQE+ + + L +L + S E +VV++Q+ L + L
Sbjct: 1345 EQRLQESKMILDEVKMHLPAL--------------ETKSVEQEVVQSQLNHCVNLYKSLS 1390
Query: 3398 DRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVA 3457
+ KS VE++ + G +I + + ++ ++++ L + L K R +QLE ++
Sbjct: 1391 EVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLS 1450
Query: 3458 QQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVS 3517
++ + + L EWL + L + S L+ ++A KA + +I HL
Sbjct: 1451 RKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITE 1510
Query: 3518 IGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELM 3577
+G++LK + +++ +V+ KL +I + ++ LL + + + F ++ +
Sbjct: 1511 VGEALKTVLGKKET-LVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHIT 1569
Query: 3578 NWLNEVHDKL--SKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQT 3635
W+ + L S+ + L + ++EL ++ + + + N + ++
Sbjct: 1570 KWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKL 1629
Query: 3636 TGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVE 3695
++ + + AI R K T ++ K LEQ ++L L+ +E E
Sbjct: 1630 VEPQISELNHRFAAISHRIK--TGKASIPLKELEQFNSDIQKL----------LEPLEAE 1677
Query: 3696 LLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKM 3755
+ + LK E+ + K++ ++ N + + L + + R RE ++
Sbjct: 1678 I--QQGVNLKEEDFN------KDMNED--NEGTVKELLQRGDNLQQRITDERKREEIKIK 1727
Query: 3756 VAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQ 3815
++ + D +Q+ ++ + Q+ + AD L + + EKKL SL + R E+
Sbjct: 1728 QQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDER 1787
Query: 3816 D--QTSAQLQVQKTFTMEILRHKDII--DDLVKSGHKIMTACSEEEKQSMKKKLDKVLKN 3871
+ +LQ +K + R + + D + S+ ++ K N
Sbjct: 1788 KIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLN 1847
Query: 3872 YDTICQINSERYLQLERAQSL-VNQFWETY----EELWPWLTETQSIISQLPAPALEYET 3926
+ I + E + + L ++ TY + L E + +++ A ++E
Sbjct: 1848 FAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFED 1907
Query: 3927 LRQQQEEHRQLRELIAEHKPHIDKMN-KTGPQLLELSPGEGFSIQEKYVAADTLYSQIKE 3985
L +Q+E + +++ + + ID ++ K L +P E +QE D + ++ +
Sbjct: 1908 LFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNK 1967
Query: 3986 DVKKRAVALDEAISQSTQFHDKI---DQILESLERIVERLRQPPSISAEVEKIKEQISEN 4042
K R D ++ + +FH I +Q L E+ + + + P + E K K + E
Sbjct: 1968 MYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENW--EHAKYKWYLKEL 2025
Query: 4043 KNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEE 4102
++ + + Q + TL GEE+I +S TD I +Q+KL + W+ + + +
Sbjct: 2026 QD---GIGQRQTVVRTLNATGEEIIQQSSKTDASI----LQEKLGSLNLRWQEVCKQLSD 2078
Query: 4103 REAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEI 4162
R+ +L + + +F D ++ +++ + +PG + + K++ E + + EE+
Sbjct: 2079 RKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQL-KEKLEQVKLLVEEL 2137
Query: 4163 DGLQEELDIVINLGSELIAACG----EPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEE 4218
Q L + G ++ + E DK ++ + + N W +++A ++ ++E
Sbjct: 2138 PLRQGILKQLNETGGPVLVSAPISPEEQDK--LENKLKQTNLQWIKVSRALPEKQGEIEA 2195
Query: 4219 AMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEE----LKQFKSEAYQQ 4274
++ Q + L+ D + L +SPI LE Q +E +++ + +
Sbjct: 2196 QIKDLGQLEKKLE---DLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAK 2252
Query: 4275 QIEMERLNHQAELLLK-KVTEESDKHTVQDPLMELKLIWDSLEER--------------- 4318
Q ++E + + + L K K + K ++D E K + L+E
Sbjct: 2253 QPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIG 2312
Query: 4319 -------------IINRQ---HKLE--GALL----ALGQFQHALDELLAWLTHTEGLLSE 4356
++ ++ KLE +L+ AL F A EL WL+ + ++
Sbjct: 2313 ASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKS 2372
Query: 4357 QKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNL-QNKLE 4415
Q+ + GD + I + K D+ + +E + A +L ++ +EA + +++E
Sbjct: 2373 QRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIE 2432
Query: 4416 VLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPET 4475
+ +W V E + R+QQL+ L+ + + E+ +Q L L + K +
Sbjct: 2433 RIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDA 2492
Query: 4476 AKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVET 4535
++++ ++ + ++L + N+ W S+
Sbjct: 2493 IQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHK 2552
Query: 4536 KLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNV---ASRPSLILDT---VLFQI 4589
+++ER+ LEE L +F L+ F+ WLT+AE T NV A+R +L+ V +
Sbjct: 2553 RVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELM 2612
Query: 4590 DEHKVFANEVNSHREQIIELDKTGTH-LKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVE 4648
+ + E+ +H + LD+ L+ D VL++ L ++ +W ++ ++ +
Sbjct: 2613 KQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLN 2672
Query: 4649 RGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSL 4708
L+ + + K+ H + +L+ WL+ + L + I D ++ Q H+ F++ L
Sbjct: 2673 IRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKREL 2732
Query: 4709 GAKHSVYDTTNRT-------------------GRSLKEKTSLADDNLKLDDMLSELRDKW 4749
K V +T T R L + + L E+ +W
Sbjct: 2733 KTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEW 2792
Query: 4750 DTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGD--IDLVMNL 4807
+ + S + Q K++E L + +A L L + E QPV GD ID + +
Sbjct: 2793 EKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPV-GDLLIDSLQDH 2851
Query: 4808 IDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISK 4867
++ KA + E+ +V + AR+L S + +++L+TRW+ +
Sbjct: 2852 LEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLL------- 2904
Query: 4868 QTRLEAALRQAEEFH 4882
Q +E +RQ E H
Sbjct: 2905 QVAVEDRVRQLHEAH 2919
Score = 316 bits (809), Expect = 5e-85
Identities = 548/2809 (19%), Positives = 1128/2809 (40%), Gaps = 353/2809 (12%)
Query: 1879 LEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYIT 1938
L+++ E WL +E L+ ++D+ + + + + D+ +H+G + I
Sbjct: 218 LDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNIL 277
Query: 1939 ISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVD 1998
G++++ K + EVQ +++ R+ L +NL ++
Sbjct: 278 QLGSKLIGTGKLSEDEE----------TEVQEQMNLLNSRWECLRVASMEKQSNLHRVLM 327
Query: 1999 KYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVE 2058
Q+ + L L E K EP+ D ++L+RQ+++ K LQ + +QV V
Sbjct: 328 DLQNQKLKE--LNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVN 385
Query: 2059 KLKKTAEVLLDARGSLLPAKNDIQ-KTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQ 2117
L V+ ++ G A + Q K L D R+ ++ + +R LQ L + +
Sbjct: 386 SLTHMVVVVDESSGDHATAALEEQLKVLGD---RWANICRWTEDRWVLLQDILLKWQRLT 442
Query: 2118 DGLDEMLDWMGNVESSLKEQGQVPLNSTALQD------IISKNIMLEQDIAGRQSSINAM 2171
+ W+ E ++ + +++T +D + K +L+ D+ ++ S+ +
Sbjct: 443 EEQCLFSAWLSEKEDAVNK-----IHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKL 497
Query: 2172 NEKVKKFMETT-DPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSE 2230
+ + T + S +A + + + + K +++ A++ + T + +L++
Sbjct: 498 YSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQ--PSLTQ 555
Query: 2231 KLQTFLETKTQALTEVDVPGKDVTEL-----SQYMQESTSEFLEHKKHLEV----LHSLL 2281
T +ET T T + K E Q ++ T + E +K L+V LHS +
Sbjct: 556 T--TVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDS-EIRKRLDVDITELHSWI 612
Query: 2282 KEISSHGLPSDKALVLEKTNNLS--------------KKFKEMEDTIKEKK--------- 2318
S L S + + K N S +KF++++D + +
Sbjct: 613 TR-SEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNE 671
Query: 2319 ----EAVTSCQEQLDA----FQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKK 2370
+++ EQL++ F L+ +W++ + E + + E+ K
Sbjct: 672 GVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLK 731
Query: 2371 LQEKWSLKTPEIQKVNNSGISLC-NLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFW 2429
+Q TP S + +C + ++ ++ I +K L +G
Sbjct: 732 IQPT----TPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKG--------- 778
Query: 2430 ANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKL--QKAQEESSAMMQWLQKMN 2487
+G + D ++ ++ + ++ + EL T L + QE SA+ W+Q+ +
Sbjct: 779 --QGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQ-S 835
Query: 2488 KTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAP 2547
+T Q TD E ++ ++ + ++ ++ L++ + + L + E+ ++ P + +
Sbjct: 836 ETKLSIPQLSV-TDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAP-SEISR 893
Query: 2548 RWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGP 2607
+++ EI+ +W++L+ ++ QKLEE N L + Q LK+W+ E ++ + P
Sbjct: 894 KYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWP 953
Query: 2608 LSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAV 2667
D +L Q +Q ++L+ + T +P + GQ I + +P ++ +L +
Sbjct: 954 ALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEA--EPEFASRLETELKEL 1011
Query: 2668 TQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMN 2727
+WD + Q+ R + + + K+ Q L + + ++ + + PD +
Sbjct: 1012 NTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQ 1071
Query: 2728 QQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAE--LSRQLEGILKSFKDVE 2785
+ +E ++ K+E QQ++ ++K+ L E +++++ + A+ L ++LE + +++ +
Sbjct: 1072 KAVEEMKRAKEEAQQKEAKVKL---LTESVNSVIAQAPPVAQEALKKELETLTTNYQWLC 1128
Query: 2786 QKAENHVQHLQSACASSHQFQQMSRDFQAWLD-------TKKEEQNKSHPISAKLDVLES 2838
+ + L+ A H+ WL+ T + + IS LD LE+
Sbjct: 1129 TRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLEN 1188
Query: 2839 LIKDHKD-------FSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQ--------- 2882
L++ +D ++TLT M E E E + + + A++ Q
Sbjct: 1189 LMRHSEDNPNQIRILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQS 1248
Query: 2883 -------LNTIKTNWDTFNKQVK-------------ERENKLKE-------SLEKALKY- 2914
L+ I+ + +KQ+ + K++ SLE+ K+
Sbjct: 1249 AQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHN 1308
Query: 2915 --KEQVETLWPWIDKCQNNLEEI--KFCL--DPAEGENSIAKLKSLQKEMDQHFGMVEL- 2967
KE + + ID Q L+++ KF L PA E + + K + E+ H +E
Sbjct: 1309 QGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETK 1368
Query: 2968 ----------LNNTANSLLSVCEIDKEV--VTDENKSLIQKVDMVTEQLHSKKFCLENMT 3015
LN+ N S+ E+ EV V + ++QK +Q + K E +T
Sbjct: 1369 SVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQK-----KQTENPKELDERVT 1423
Query: 3016 QKFKEFQEVSK---ESKRQLQ-CAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQ 3071
+ E+ E K+QL+ C K + + M T++ +++ +
Sbjct: 1424 ALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSN 1483
Query: 3072 VDL----AKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGI 3127
+D K +++ + K ++V ++T+ + TL V++K S L + +
Sbjct: 1484 LDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETL---VEDKLSLLNSNWIAV 1540
Query: 3128 G----HFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASND 3183
+ N + E FD +D + A+TL + E K K+ + L
Sbjct: 1541 TSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKE-DVLKRLKA 1599
Query: 3184 NANKTCKMMLATEETSPDLVGIKRD--LEALSKQCNKLLDRAQAREEQVEG-----TIKR 3236
N + +T + + +L+ + D + + Q ++L R A +++ +K
Sbjct: 1600 ELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKE 1659
Query: 3237 LEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDV 3296
LE+F S +++ LL+ E E Q V ++ E N+ +N E +G +++
Sbjct: 1660 LEQFNSDIQK---LLEPLEA--EIQQGVNLKEEDFNKDMN----------EDNEGTVKEL 1704
Query: 3297 NWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALE 3356
G L Q + ++ + + L +QR + E +++ +
Sbjct: 1705 LQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQAD 1764
Query: 3357 SLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKI--- 3413
LL + D E+ +A+ P E K+ K + R L +K + ++R+ E +
Sbjct: 1765 DLLKCLDDIEKKLASLPEPRDERKI--------KEIDRELQKKKEELNAVRRQAEGLSED 1816
Query: 3414 --ATTAEPADKVKILKQLSLLDSRWEAL--LNKAE------------TRNRQLEGISVVA 3457
A EP ++++ K+ ++S++ LN A+ T + LE IS V
Sbjct: 1817 GAAMAVEPT-QIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLE-ISYVP 1874
Query: 3458 QQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHL---HQ 3514
+ + +++ L +E+ L + L +Q K ++D + + + H
Sbjct: 1875 STYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHS 1934
Query: 3515 AVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEV 3574
+ R S+LDF + ++ + R +++ + F D
Sbjct: 1935 KKTAALQSATPVERVKLQEALSQLDFQ---WEKVNKMYKDRQGRFDRSVEKWRRFHYDIK 1991
Query: 3575 ELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQ 3634
WL E L K + + +K L+ LQ+ I R+ V G E+++Q
Sbjct: 1992 IFNQWLTEAEQFLRKTQIPENWEHAKYKWY--LKELQDGIGQRQTVVRTLNATGEEIIQQ 2049
Query: 3635 TTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEV 3694
++ + I+Q+KL ++ R++++ K +D K LE+ + E WL++ +
Sbjct: 2050 SSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEAD- 2108
Query: 3695 ELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREG--L 3752
+ S + K ++ + + K L +E + +L LNE +L P E L
Sbjct: 2109 NIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKL 2168
Query: 3753 EKMVAEDNERYRLVSDTITQKVEEIDAAIL-------RSQQFDQAADAELSWITETEKKL 3805
E + + N ++ VS + +K EI+A I + + ++ + L W++ +L
Sbjct: 2169 ENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQL 2228
Query: 3806 MSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKL 3865
Q VQ+T + D+ + L K H + Q +K+KL
Sbjct: 2229 EIYN-----QPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYK---EKPATQPVKRKL 2280
Query: 3866 DKVLKNYDTICQINSE-RYLQLERAQ-------------SLVNQFWETYEELWPWLTETQ 3911
+ + + + ++ E R Q + A +LV Q T E L
Sbjct: 2281 EDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPS 2340
Query: 3912 SIISQLPAPA--------------LEYETLRQQQE---EHRQLRELIAEHKPHIDKMNKT 3954
S++ ++PA A L + ++ Q+ + + E+I + K + + +
Sbjct: 2341 SLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQR 2400
Query: 3955 GPQLLEL-----------SPGEGFSI-QEKYVAADTLYSQIKEDVKKRAVALDEAISQST 4002
PQL EL S E +I ++ + +++E ++ R L+E + ST
Sbjct: 2401 RPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDST 2460
Query: 4003 QF---HDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETL 4059
Q+ ++ +Q+L +E ++ P V+ I+++I+E K ++ D+ + Q +
Sbjct: 2461 QWLEAKEEAEQVLGQARAKLESWKEGPYT---VDAIQKKITETKQLAKDLRQWQTNVDVA 2517
Query: 4060 KQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWC 4119
+++ R D + + ++ W +IH V EREA L + L ++F
Sbjct: 2518 NDLALKLL-RDYSADDTRKVHMITENINAS---WRSIHKRVSEREAALEETHRLLQQFPL 2573
Query: 4120 DHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEEL----DIVINL 4175
D + + + + L+D +++ + E +++ D LQ E+ D+ NL
Sbjct: 2574 DLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQD-LQGEIEAHTDVYHNL 2632
Query: 4176 GSE----LIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQ 4231
L + G D ++++ +D +N W L K + LE + + LQ
Sbjct: 2633 DENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQ 2692
Query: 4232 AVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAY------------------Q 4273
+ W+ + +L+ +PIG D V++Q + + FK E +
Sbjct: 2693 ELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTE 2752
Query: 4274 QQIE-MERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLA 4332
Q +E +E+L + L + ++ ++ E+ W+ L + Q K++ L
Sbjct: 2753 QPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLER 2812
Query: 4333 LGQFQHALDELLAWLTHTEGLLSEQKPVGG-DPKAIEIELAKHHVLQNDVLAHQSTVEAV 4391
L + Q A DEL L E + +PVG +++ L K L+ ++ + V V
Sbjct: 2813 LQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHV 2872
Query: 4392 NKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALR 4440
N L NL + LE LN RW+ + E R +QL A R
Sbjct: 2873 NDLARQLTTLGIQLSPYNL-STLEDLNTRWKLLQVAVEDRVRQLHEAHR 2920
Score = 313 bits (803), Expect = 2e-84
Identities = 505/2706 (18%), Positives = 1066/2706 (39%), Gaps = 308/2706 (11%)
Query: 2413 GAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKA 2472
G+ L G G + EE T +++ M ++ +E L + +K + L+ L LQ
Sbjct: 280 GSKLIGTGKLSEDEE-------TEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQN- 331
Query: 2473 QEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDK 2532
++ + WL K + K ++ P D E +K QV+Q+K + +L+Q +V L
Sbjct: 332 -QKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHM 390
Query: 2533 LTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLK 2592
+ + E + D A +Q L + +W + + T DR L++ + +
Sbjct: 391 VVVVDESSGDHATAALEEQ-LKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFS 449
Query: 2593 QWLVEKELMVSVLGPLSI-DPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPG 2651
WL EKE V+ + D N + + Q++ +L + +K +L + Q +LS
Sbjct: 450 AWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTL- 508
Query: 2652 EDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKS-----------------TQ 2694
++ S+ + L + WD+L +L I QA+ + T+
Sbjct: 509 KNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTR 568
Query: 2695 YQSLLRSLSDKLSD----------LDNKLSSSLAVS--------THPDAMNQQLETAQKM 2736
Q L++ ++L +D+++ L V T +A+ Q E A
Sbjct: 569 EQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFR 628
Query: 2737 KQ-----------EIQQEKKQ--------IKVAQALCEDL-SALVKEEYLKAELSRQLEG 2776
K+ I++EK + + AQAL E + + V + +K + S QL
Sbjct: 629 KEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIK-QASEQLNS 687
Query: 2777 ILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPIS-AKLDV 2835
F + + N +++ + A +Q QQ+ + + T E K P + ++
Sbjct: 688 RWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQ-----MTTTAENWLKIQPTTPSEPTA 742
Query: 2836 LESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNK 2895
++S +K KD L+ E+ + +++ LK +G L ++
Sbjct: 743 IKSQLKICKDEVNRLSGLQPQIERL--KIQSIALKEKGQGPMFLDADFVAFTNHFKQVFS 800
Query: 2896 QVKERENKLKESLEKA--LKYKEQVETLWPWIDKCQNNLEEIKFCLDPAE-GENSIAKLK 2952
V+ RE +L+ + ++Y+E + + W+ + + L + + E E + +L+
Sbjct: 801 DVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQ 860
Query: 2953 SLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLE 3012
+LQ + + + L+ T V E+ K+ ++ ++ + + + + L
Sbjct: 861 ALQSSLQEQQSGLYYLSTT------VKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLV 914
Query: 3013 NMTQKFKEFQEVSKESKRQLQCAKE---QLDIH-----DSLGSQAYSNKYLTMLQTQQKS 3064
QK +E ++ + +Q K+ ++D+ +LG K L +
Sbjct: 915 EHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSD 974
Query: 3065 LQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKL 3124
+Q ++ ++ Q + EA + + S + +++ + + + QQV + L+ L
Sbjct: 975 IQTIQPSLNSVNEGGQKIKNEA-EPEFASRLETELKELNTQWDHMCQQVYARKEALKGGL 1033
Query: 3125 QGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDN 3184
+ Q + EM + ++E + + LQK E +K A +
Sbjct: 1034 EKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKR---------AKEEA 1084
Query: 3185 ANKTCKMMLATEETSPDLV--------GIKRDLEALSKQCNKLLDRAQAREEQVEGTIKR 3236
K K+ L TE + + +K++LE L+ L R + + +E
Sbjct: 1085 QQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWAC 1144
Query: 3237 LEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDV 3296
E S L++ + L + E ++ + E I++ L+ + + + +
Sbjct: 1145 WHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHS----EDNPNQI 1200
Query: 3297 NWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALE 3356
L Q L + + +L+ N+RW+ L+++ +R L++++ Q A E
Sbjct: 1201 RILAQTLTDGGVMD---ELINEELETFNSRWRELHEEAVRRQKLLEQSI------QSAQE 1251
Query: 3357 SLLSWMVDTEELVANQKPPSAEF--KVVKAQI-QEQKLLQRLLDDRKSTVEVIKREGEKI 3413
+ S + E L K +A KV AQ+ QE + +Q L + ++E +K+ +
Sbjct: 1252 TEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGK 1311
Query: 3414 ATTAEPADKVKIL-KQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLT 3472
++ + K+L + ++ A R E + L+ + L
Sbjct: 1312 EAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMI--------LDEVKMHLP 1363
Query: 3473 TIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKD 3532
+E + V E + +Q L + +K+L + + + G+ + E+
Sbjct: 1364 ALETKSVEQEVVQSQ---LNHCVNLYKSLSEV----KSEVEMVIKTGRQIVQKKQTENPK 1416
Query: 3533 MVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSV 3592
+ ++ ++ Y E+ K R + L++ L ++ ++ L WL +L+K S
Sbjct: 1417 ELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSA 1476
Query: 3593 QDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKA 3652
+ L + + + Q++I +K ++ G E LK G + +++DKL + +
Sbjct: 1477 VEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVG-EALKTVLGKKETLVEDKLSLLNS 1535
Query: 3653 RYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQA 3712
+ +T + + L + + + + W+ ++ + L E++ K ++
Sbjct: 1536 NWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWI--IQADTLLDESEKKKPQQKEDV 1593
Query: 3713 QMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQ 3772
K LK E + + +DS + ++ L+ R+ +E ++E N R+ +S I
Sbjct: 1594 L---KRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRI-- 1648
Query: 3773 KVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEI 3832
K + + +QF+ +KL+ + ++Q + K +
Sbjct: 1649 KTGKASIPLKELEQFNSDI-----------QKLLEPLEAEIQQGVNLKEEDFNKDMNED- 1696
Query: 3833 LRHKDIIDDLVKSGHKIMTACSEEEK-QSMKKKLDKVLKNYDTICQINSERYLQLERAQS 3891
++ + +L++ G + ++E K + +K K + ++ + + S+R +
Sbjct: 1697 --NEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISH 1754
Query: 3892 LVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKM 3951
Q+ ++L L + + ++ LP P + R+++E+ E + +++
Sbjct: 1755 QWYQYKRQADDLLKCLDDIEKKLASLPEP-----------RDERKIKEIDRELQKKKEEL 1803
Query: 3952 NKTGPQLLELSP-GEGFSIQEKYVAADTLYSQIKE---DVKKRAVALDEAISQSTQFHDK 4007
N Q LS G +++ + + +I+ ++ A + + T
Sbjct: 1804 NAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMT 1863
Query: 4008 IDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMI 4067
D LE L + +S + ++++ ++ + D E L E+LK + +
Sbjct: 1864 EDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQ 1923
Query: 4068 ARSGGTDKDISAKA-------------VQDKLDQMVFIWENIHTLVEEREAKLLDVMELA 4114
SG D S K +Q+ L Q+ F WE ++ + ++R+ + +E
Sbjct: 1924 QSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKW 1983
Query: 4115 EKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAET---IREEIDGLQEELDI 4171
+F D + + + F+R + P + E A+ ++E DG+ + +
Sbjct: 1984 RRFHYDIKIFNQWLTEAEQFLRKTQIP--------ENWEHAKYKWYLKELQDGIGQRQTV 2035
Query: 4172 VINL---GSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQD 4228
V L G E+I + D I+++ + LN W + K DR +LEE ++Q
Sbjct: 2036 VRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQR 2095
Query: 4229 GLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELL 4288
L W++ A +AS+ + +K+++E++K E +Q +++LN +
Sbjct: 2096 DLNEFVLWLEEADN-IASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPV 2154
Query: 4289 LKKVT---EESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDEL-- 4343
L EE DK +++ L + L W + + +Q ++E + LGQ + L++L
Sbjct: 2155 LVSAPISPEEQDK--LENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEE 2212
Query: 4344 -----LAWLTHTEGLLS--EQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGN 4396
L WL+ L Q G E E+A V A Q VE + G
Sbjct: 2213 QLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIA--------VQAKQPDVEEILSKGQ 2264
Query: 4397 DLIESSAGEEASNLQNKLEVLNQRWQNV-------------------------------- 4424
L + + ++ KLE L+ W+ V
Sbjct: 2265 HLYKEKPATQP--VKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLV 2322
Query: 4425 -----LEKTEQRKQQLDGALR----QAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPET 4475
++T K ++ +L F+ +L WL+ ++ + + + + G E
Sbjct: 2323 TQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLED 2382
Query: 4476 AKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCP-KSAETNIDQDINNLKEKWESVE 4534
E + E + + L+ Q + + + A T I I ++ +W+ V+
Sbjct: 2383 INEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQ 2442
Query: 4535 TKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKV 4594
L R+ +L E L + ++ + ++ L QA L +D + +I E K
Sbjct: 2443 EHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQ 2502
Query: 4595 FANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLD 4654
A ++ + + + L D + + ++ + W + +R+ ER +L+
Sbjct: 2503 LAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALE 2562
Query: 4655 DARKRAKQFHEAWSKLMEWLEESEKSLD------SELEIANDPDKIKTQLAQHKEFQKSL 4708
+ + +QF K + WL E+E + + + + D +K + Q ++ Q +
Sbjct: 2563 ETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEI 2622
Query: 4709 GAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALL 4768
A VY + + + +DD + L L + KW + KS+ ++ LE +
Sbjct: 2623 EAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSD 2682
Query: 4769 FSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRT------ 4822
+ +LQ L+ WL + +L+ P+ GD V D H+AF++EL +
Sbjct: 2683 QWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMST 2742
Query: 4823 -------------SSVQALKRSARELI--EGSRDDSSWVKVQMQELSTRWETVCALSISK 4867
++ L + REL E +++ + ++ Q +E++T WE + S
Sbjct: 2743 LETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADW 2802
Query: 4868 QTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLE 4927
Q +++ L + +E L L +AE + D LID ++ ++K++
Sbjct: 2803 QRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGD------LLIDSLQDHLEKVK 2856
Query: 4928 EKRAEL 4933
R E+
Sbjct: 2857 ALRGEI 2862
Score = 308 bits (789), Expect = 1e-82
Identities = 502/2696 (18%), Positives = 1071/2696 (39%), Gaps = 346/2696 (12%)
Query: 2690 VKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKV 2749
V +YQ+ L + L ++ L + +S + + Q T + ++ + ++
Sbjct: 216 VNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGN 275
Query: 2750 AQALCEDLSALVK-EEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQM 2808
L L K E + E+ Q+ +L S + + A Q Q Q++
Sbjct: 276 ILQLGSKLIGTGKLSEDEETEVQEQMN-LLNSRWECLRVASMEKQSNLHRVLMDLQNQKL 334
Query: 2809 SRDFQAWLDTKKEEQNKS---HPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGE 2865
++ WL TK EE+ + P+ L+ L+ ++ HK + L Q + ++
Sbjct: 335 -KELNDWL-TKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLE-QEQVRVNSLTHMV 391
Query: 2866 NLLLKTQGSEK-AALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPW 2924
++ ++ G AAL+ QL + W + ++R L++ L K + E+ W
Sbjct: 392 VVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAW 451
Query: 2925 IDKCQNNLEEIKFC--LDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEID 2982
+ + ++ + +I D E +S+ KL L+ ++++ + L + LLS +
Sbjct: 452 LSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLST--LK 509
Query: 2983 KEVVTDENKS-----------LIQKVDMVTEQLH----------SKKFCLENMTQKFKEF 3021
+ VT + ++ L+QK++ T Q+ ++ +E +T
Sbjct: 510 NKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTRE 569
Query: 3022 QEVSK-----------ESKRQLQCAKE---QLDIHDSLGSQAYSNKYLTMLQT------- 3060
Q + K + KRQ+ E +LD+ D ++ + +LQ+
Sbjct: 570 QILVKHAQEELPPPPPQKKRQITVDSEIRKRLDV-DITELHSWITRSEAVLQSPEFAIFR 628
Query: 3061 QQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQ--------VETIAQEHSTLSQQ 3112
++ + LK +V+ +R + + D+ ++ L++ ++I Q L+ +
Sbjct: 629 KEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSR 688
Query: 3113 VDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFL 3172
E C L +L + +QN I ++Q + + + + T + IK+ L
Sbjct: 689 WIEFCQLLSERLNWL-EYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQL 747
Query: 3173 K----KLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREE 3228
K ++ L + +A +E + + D A + ++ QARE+
Sbjct: 748 KICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREK 807
Query: 3229 QVEGTIKRLE--EFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEI 3286
+++ L + + +Q++E + E + Q+L + Q
Sbjct: 808 ELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSS-- 865
Query: 3287 EPLQGKQQDVNWLGQGLIQSAAKSTS--TQGLEHDLDDVNARWKTLNKKVAQRAAQLQEA 3344
LQ +Q + +L + + + K+ S ++ + + +++ RWK L+ ++ + +L+E
Sbjct: 866 --LQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQ 923
Query: 3345 LLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVE 3404
+ + Q+ +++L WM + + + + P + +++K Q+++ +LL + + ++
Sbjct: 924 MNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLN 983
Query: 3405 VIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETL 3464
+ G+KI AEP ++ +L L+++W+ + + R L+G + L
Sbjct: 984 SVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDL 1043
Query: 3465 EPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKV 3524
++EW+T E+ + + +L++ + + K +++ + S+
Sbjct: 1044 SEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIA 1103
Query: 3525 LSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQA-LCNAKIFGEDEVELMNWLNEV 3583
+ ++ ++ +L+ Y + + + + + L++ C ++ E + WLNEV
Sbjct: 1104 QAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLE-KANKWLNEV 1162
Query: 3584 HDKLSKLSVQDYSTEGLWKQQSEL-RVLQEDILLRKQNVDQALLNGLELLKQTTGDEVL- 3641
KL +TE + E+ VL L + + D N + +L QT D +
Sbjct: 1163 EFKLK-------TTENIPGGAEEISEVLDSLENLMRHSEDNP--NQIRILAQTLTDGGVM 1213
Query: 3642 --IIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLH-STH--EELCTWLDK----- 3691
+I ++LE +R++++ + + K LEQ++Q A+ S H +E T++DK
Sbjct: 1214 DELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAY 1273
Query: 3692 ----------------VEVELLSYETQVLK------GEEASQAQM--------------- 3714
++ +L S+E + + G+EA+Q +
Sbjct: 1274 IADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSM 1333
Query: 3715 ------RPKELKKEAKNNKALLD-------------------------------SLNEVS 3737
+P ++ + +K +LD SL+EV
Sbjct: 1334 KFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVK 1393
Query: 3738 SALLELVPWRAREGLEKMVAED----NER-------YRLVSDTITQKVEEIDAAILRSQQ 3786
S + E+V R+ ++K E+ +ER Y + +T++ ++++ + S++
Sbjct: 1394 SEV-EMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRK 1452
Query: 3787 FDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSG 3846
+ + W+ T+ +L + +++ K EI + K + + + G
Sbjct: 1453 MRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVG 1512
Query: 3847 HKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPW 3906
+ T ++E ++ KL + N+ + E L Q + F + + + W
Sbjct: 1513 EALKTVLGKKETL-VEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKW 1571
Query: 3907 LTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEG 3966
+ + +++ E E + QQ+E L+ L AE K++ T Q L G
Sbjct: 1572 IIQADTLLD-------ESEKKKPQQKED-VLKRLKAELNDIRPKVDSTRDQAANLMANRG 1623
Query: 3967 FS----IQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERL 4022
++ + + ++ I +K ++ + + QF+ I ++LE LE +++
Sbjct: 1624 DHCRKLVEPQISELNHRFAAISHRIKTGKASIP--LKELEQFNSDIQKLLEPLEAEIQQ- 1680
Query: 4023 RQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAV 4082
++ + E + ++E+ +V + L QRG+ + R K K
Sbjct: 1681 ----GVNLKEEDFNKDMNEDNEGTV---------KELLQRGDNLQQRITDERKREEIKIK 1727
Query: 4083 QDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPG 4142
Q L + L +R K L++ ++ L+ + D + + L +P
Sbjct: 1728 QQLLQTK---HNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPR 1784
Query: 4143 IDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAW 4202
D +K+ + +EE++ ++ + + L + A EP + + K E+ S +
Sbjct: 1785 -DERKIKEIDRELQKKKEELNAVRRQAE---GLSEDGAAMAVEPTQIQLSKRWREIESKF 1840
Query: 4203 DSLNKAWKDRIDKL-EEAMQAAVQ------------YQDGLQAVFDWVDIAGGKLASMSP 4249
+ +I + EE M + Y + V + L +
Sbjct: 1841 AQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDL 1900
Query: 4250 IGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELK 4309
D E + +Q E LK K Q ++ ++ + L+ T ++ +Q+ L +L
Sbjct: 1901 CAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPV-ERVKLQEALSQLD 1959
Query: 4310 LIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSE-QKPVGGDPKAIE 4368
W+ + + +RQ + + ++ +F + + WLT E L + Q P + +
Sbjct: 1960 FQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYK 2019
Query: 4369 IELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKT 4428
L + LQ+ + Q+ V +N G ++I+ S+ +AS LQ KL LN RWQ V ++
Sbjct: 2020 WYLKE---LQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQL 2076
Query: 4429 EQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLG-GLPETAKEQLNVHMEVC 4487
RK++L+ F ++ + WL + + +AS PL G + KE+L +
Sbjct: 2077 SDRKKRLEEQKNILSEFQRDLNEFVLWLEEADN--IASIPLEPGKEQQLKEKLEQVKLLV 2134
Query: 4488 AAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKE---KWESVETKLNERKTKL 4544
++ K L + G +L P S E D+ N LK+ +W V L E++ ++
Sbjct: 2135 EELPLRQGILKQLNETGGPVLVSAPISPEEQ-DKLENKLKQTNLQWIKVSRALPEKQGEI 2193
Query: 4545 EEALNLAMEFHNSLQDF-------INWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFAN 4597
E + + L+D + WL+ L + ++P+ F + E ++
Sbjct: 2194 EAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPN---QEGPFDVQETEI--- 2247
Query: 4598 EVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGR------ 4651
V + + + E+ G HL + +K +K L + S W K V RL++ R
Sbjct: 2248 AVQAKQPDVEEILSKGQHL--YKEKPATQPVKRKLEDLSSEW-KAVNRLLQELRAKQPDL 2304
Query: 4652 ------------------------------------SLDDARKRAKQFHEAWSKLMEWLE 4675
SL F+ AW++L +WL
Sbjct: 2305 APGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLS 2364
Query: 4676 ESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDN 4735
++ + S+ + D + I + + K + L + + ++LK KTS +
Sbjct: 2365 LLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEAR 2424
Query: 4736 LKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQ 4795
+ D + ++++WD + R+ +L E L S Q+ +A + L + +L +
Sbjct: 2425 TIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWK 2484
Query: 4796 PVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEG-SRDDSSWVKVQMQELS 4854
+D + I K K+L + ++V A +L+ S DD+ V + + ++
Sbjct: 2485 EGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENIN 2544
Query: 4855 TRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRT 4914
W ++ ++ LE R ++F + L WL EAE T VL D R
Sbjct: 2545 ASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTAN---VLQDATRKERL 2601
Query: 4915 LIDQH--KEFMKKLEEKRAELNKATTMGDTV--------LAICHPDSITTIKHWITIIRA 4964
L D KE MK+ ++ + E+ T + + ++ D ++ + +
Sbjct: 2602 LEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNF 2661
Query: 4965 RFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVK 5024
++ E+ + + L ++ L+ LL WLQ + L+ + I + V+
Sbjct: 2662 KWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAP--IGGDFPAVQ 2719
Query: 5025 ALIAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLY 5084
H+ F E+ K+P + +T + I + ++ G ++ LY
Sbjct: 2720 KQNDVHRAFKRELKTKEPVIMSTLETVR------------IFLTEQPLEGLEK-----LY 2762
Query: 5085 PSGSQTQIETKNPRVNLLVSK--------WQQVWLLALERRRKLNDALDRLEELRE 5132
+ E + V L+ K W+++ L + + +RK+++ L+RL+EL+E
Sbjct: 2763 QEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQE 2818
Score = 295 bits (755), Expect = 9e-79
Identities = 474/2585 (18%), Positives = 1053/2585 (40%), Gaps = 294/2585 (11%)
Query: 2574 LEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRK 2633
L ES NL ++QT ++ WL+ E + G +S D ++ Q + + + +
Sbjct: 211 LMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQ 270
Query: 2634 PQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKST 2693
+ + G ++ V+EQ+ + +W+ L ++ + + ++
Sbjct: 271 GRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQ 330
Query: 2694 QYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDA--MNQQLETAQKMKQEIQQEKKQIK--V 2749
+ L+ L+D L+ + + PD + +Q++ + ++++++QE+ ++
Sbjct: 331 NQK--LKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLT 388
Query: 2750 AQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMS 2809
+ D S+ ++ A L QL+ + + ++ + E+ LQ + +
Sbjct: 389 HMVVVVDESS---GDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQ 445
Query: 2810 RDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLL 2869
F AWL K++ NK H KD + +L
Sbjct: 446 CLFSAWLSEKEDAVNKIHTTG---------FKDQNEMLSSL------------------- 477
Query: 2870 KTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWID--- 2926
+ A L+ L KQ + LK+ L LK K + W+D
Sbjct: 478 ----QKLAVLKADLEK--------KKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFA 525
Query: 2927 KCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVV 2986
+C +NL + L+ + + S A + + Q + Q M + T + V +E+
Sbjct: 526 RCWDNLVQ---KLEKSTAQISQA-VTTTQPSLTQTTVMETVTTVTTREQILVKHAQEELP 581
Query: 2987 TDE---------NKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKE 3037
+ + +++D+ +LHS E + Q EF KE KE
Sbjct: 582 PPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQS-PEFAIFRKEG--NFSDLKE 638
Query: 3038 QLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLL 3097
+++ + ++ + LQ +S QAL VE ++G +
Sbjct: 639 KVNAIEREKAEKFRK-----LQDASRSAQAL---------------VEQMVNEG-----V 673
Query: 3098 QVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRD 3157
++I Q L+ + E C L +L + +QN I ++Q + + + +
Sbjct: 674 NADSIKQASEQLNSRWIEFCQLLSERLNWL-EYQNNIIAFYNQLQQLEQMTTTAENWLKI 732
Query: 3158 AETLQKQKETIKAFLK----KLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALS 3213
T + IK+ LK ++ L + +A +E + + D A +
Sbjct: 733 QPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFT 792
Query: 3214 KQCNKLLDRAQAREEQVEGTIKRLE--EFYSKLKEFSILLQKAEEHEESQGPVGMETETI 3271
++ QARE++++ L + + +Q++E + E +
Sbjct: 793 NHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIM 852
Query: 3272 NQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTS--TQGLEHDLDDVNARWKT 3329
Q+L + Q LQ +Q + +L + + + K+ S ++ + + +++ RWK
Sbjct: 853 EQRLGELQALQSS----LQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKK 908
Query: 3330 LNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQ 3389
L+ ++ + +L+E + + Q+ +++L WM + + + + P + +++K Q+++
Sbjct: 909 LSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQC 968
Query: 3390 KLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQ 3449
+LL + + ++ + G+KI AEP ++ +L L+++W+ + + R
Sbjct: 969 RLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEA 1028
Query: 3450 LEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHN 3509
L+G + L ++EW+T E+ + + +L++ + + K +++
Sbjct: 1029 LKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKE 1088
Query: 3510 KHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQA-LCNAKI 3568
+ S+ + ++ ++ +L+ Y + + + + + L++ C ++
Sbjct: 1089 AKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHEL 1148
Query: 3569 FGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSEL-RVLQEDILLRKQNVDQALLN 3627
E + WLNEV KL +TE + E+ VL L + + D N
Sbjct: 1149 LSYLE-KANKWLNEVEFKLK-------TTENIPGGAEEISEVLDSLENLMRHSEDNP--N 1198
Query: 3628 GLELLKQTTGDEVL---IIQDKLEAIKARYKDITKLSTDVAKTLEQALQLA----RRLHS 3680
+ +L QT D + +I ++LE +R++++ + + K LEQ++Q A + LH
Sbjct: 1199 QIRILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHL 1258
Query: 3681 THEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSAL 3740
E L T++DK +L +Y + +A+Q ++++ + +++ L+ + + +
Sbjct: 1259 IQESL-TFIDK---QLAAY---IADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHN--- 1308
Query: 3741 LELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQ---FDQAADAELSW 3797
+ +E ++++++ D +K++++ Q+ F+Q
Sbjct: 1309 ------QGKEAAQRVLSQ--------IDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMI 1354
Query: 3798 ITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEE 3857
+ E + L +L +EQ+ +QL + K ++ ++K+G +I+ E
Sbjct: 1355 LDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTEN 1414
Query: 3858 KQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQL 3917
+ + +++ + +Y+ + +ER QLE+ L + + L WL T +++
Sbjct: 1415 PKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKR 1474
Query: 3918 PAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAAD 3977
A L + + ++ I + K H+ + + G L + + +++K
Sbjct: 1475 SAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKL---- 1530
Query: 3978 TLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKE 4037
+L + V RA +E ++ ++ ++ ++++ I + + Q ++ E EK K
Sbjct: 1531 SLLNSNWIAVTSRA---EEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKP 1587
Query: 4038 QISEN--KNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWEN 4095
Q E+ K + ++ ++P ++ + + ++A G D K V+ ++ ++ +
Sbjct: 1588 QQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRG----DHCRKLVEPQISELNHRFAA 1643
Query: 4096 IHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAA 4155
I ++ +A + ++ E+F D L+ ++ +L++ + + + +
Sbjct: 1644 ISHRIKTGKASI--PLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTV 1701
Query: 4156 ETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDK 4215
+ + + D LQ+ + E + +K L + ++L R K
Sbjct: 1702 KELLQRGDNLQQRI-------------TDERKREEIKIKQQLLQTKHNALKDLRSQRRKK 1748
Query: 4216 LEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQ 4275
E QY+ + +D KLAS+ P D +K+ EL++ K
Sbjct: 1749 ALEISHQWYQYKRQADDLLKCLDDIEKKLASL-PEPRDERKIKEIDRELQKKKE------ 1801
Query: 4276 IEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIIN-------RQHKL-E 4327
E+ + QAE L +E+ V+ ++L W +E + + H + E
Sbjct: 1802 -ELNAVRRQAEGL----SEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVRE 1856
Query: 4328 GALLALG-----QFQHALDELLAWLTHTEGLLSEQKPVGGDP----KAIEIELAKHHVLQ 4378
++ + + + L +TH L E + + P K E + L+
Sbjct: 1857 ETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLK 1916
Query: 4379 N--DVLAHQS-TVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQL 4435
N D L S ++ ++ ++S+ E LQ L L+ +W+ V + + R+ +
Sbjct: 1917 NIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRF 1976
Query: 4436 DGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPET---AKEQLNVHMEVCAAFEA 4492
D ++ + + FH +I+ QWLT+ E+ L ++ +PE AK + + E+
Sbjct: 1977 DRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQ----IPENWEHAKYKWYL-KELQDGIGQ 2031
Query: 4493 KEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAM 4552
++ ++L G++++ + K+ + + + + +L +W+ V +L++RK +LEE N+
Sbjct: 2032 RQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILS 2091
Query: 4553 EFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKT 4612
EF L +F+ WL +A+ ++ P + ++++ K+ E+ + + +L++T
Sbjct: 2092 EFQRDLNEFVLWLEEADNIASIPLEPGK-EQQLKEKLEQVKLLVEELPLRQGILKQLNET 2150
Query: 4613 G----THLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERG-------RSLDDARKRAK 4661
G ++QD ++N L +W KV + L E+ + L K+ +
Sbjct: 2151 GGPVLVSAPISPEEQD--KLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLE 2208
Query: 4662 QFHEAWSKLMEWLEESEKSLDSELEIANDP------DKIKTQL---AQHKEFQKSLGAKH 4712
E + L+ WL + ++LEI N P D +T++ A+ + ++ L
Sbjct: 2209 DLEEQLNHLLLWL----SPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQ 2264
Query: 4713 SVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWD------TICGKS---------- 4756
+Y T ++ L+ + ++ +L ELR K T G S
Sbjct: 2265 HLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQ 2324
Query: 4757 -----------VERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVM 4805
+E + L + F A L DWL ++ + + + GD++ +
Sbjct: 2325 PVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDIN 2384
Query: 4806 NLIDNHKAFQKELGKRTSSVQALKRSARELIE--GSRDDSSWVKVQMQELSTRWETVCAL 4863
+I KA ++L +R ++ L +A+ L +++ + + +++ + +W+ V
Sbjct: 2385 EMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEH 2444
Query: 4864 SISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFM 4923
+++ +L L+ + ++ + L +A L P DA++ I + K+
Sbjct: 2445 LQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLA 2504
Query: 4924 KKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASA 4983
K L + + ++ A + +L D + H IT E + A + +R++
Sbjct: 2505 KDLRQWQTNVDVANDLALKLLRDYSADDTRKV-HMIT------ENINASWRSIHKRVSER 2557
Query: 4984 LAGLIAKQEL-------LEALLAWLQWAETT---LTDKD-KEVIPQEIEEVKALIAEHQT 5032
A L L LE LAWL AETT L D KE + ++ + VK L+ + Q
Sbjct: 2558 EAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQD 2617
Query: 5033 FMEEM 5037
E+
Sbjct: 2618 LQGEI 2622
Score = 277 bits (708), Expect = 2e-73
Identities = 491/2725 (18%), Positives = 1089/2725 (39%), Gaps = 258/2725 (9%)
Query: 2117 QDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVK 2176
Q L+E+L W+ + E +L+ QG++ + ++D + D+ Q + + +
Sbjct: 222 QTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNILQLGS 281
Query: 2177 KFMETTDPST--ASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQT 2234
K + T S + +Q +M L++R+ E + + + ++L ++L
Sbjct: 282 KLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLH--RVLMDLQNQKLKELND 339
Query: 2235 FLETKTQALT---EVDVPGKDVTELSQYMQESTSEFLEHK---KHLEVLHSLLKEISSHG 2288
+L TKT+ T E + G D+ +L + +Q+ HK + LE + ++
Sbjct: 340 WL-TKTEERTRKMEEEPLGPDLEDLKRQVQQ-------HKVLQEDLEQEQVRVNSLTHMV 391
Query: 2289 LPSDKALVLEKTNNLSKKFKEMEDT----IKEKKEAVTSCQEQLDAFQVLVKS---LKSW 2341
+ D++ T L ++ K + D + ++ Q+ L +Q L + +W
Sbjct: 392 VVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAW 451
Query: 2342 IKETTKKVPIVQPSFGAEDLGKSLEDTKKLQ--------------EKWSLKTPEIQKVNN 2387
+ E V + + G +D + L +KL + +SLK + + N
Sbjct: 452 LSEKEDAVNKIHTT-GFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKN 510
Query: 2388 SGIS------LCNLI----SAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSI 2437
++ L N + V K+ A + AV + + T T +T+
Sbjct: 511 KSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQ--AVTTTQPSLTQTTVMETVTTVTT- 567
Query: 2438 KKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTP 2497
++ + H E+L K ++ ++ + + + W+ + Q+P
Sbjct: 568 -REQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVL----QSP 622
Query: 2498 --APTDTEAVKTQVEQN-KSFEAELKQNVNKVQELKDKLTELLEENPDTP-EAPRWKQML 2553
A E + +++ + E E + K+Q+ L+E+ + A KQ
Sbjct: 623 EFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQAS 682
Query: 2554 TEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPN 2613
+++S+W E QL +R LE NN+ F QL+Q E + + +P
Sbjct: 683 EQLNSRWIEFCQLLSERLNWLEYQ-NNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPT 741
Query: 2614 MLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDS 2673
+ +Q + + + + +PQ E+L L G+ P + A T +
Sbjct: 742 AIKSQLKICKDEVNRLSGLQPQIERLKIQSIA-LKEKGQGPMF---LDADFVAFTNHFKQ 797
Query: 2674 LTGQLSDRCDWIDQAI--VKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLE 2731
+ + R + + +YQ + ++ + + KLS T + M Q+L
Sbjct: 798 VFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLG 857
Query: 2732 TAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENH 2791
Q ++ +Q+++ + +++S E + + + E I +K + + H
Sbjct: 858 ELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSE-ISRKYQSEFEEIEGRWKKLSSQLVEH 916
Query: 2792 VQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLT 2851
Q L+ + Q + + W+ + P ++L+ +K + +
Sbjct: 917 CQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQ 976
Query: 2852 AQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKA 2911
G+ + + + + L+ +L + T WD +QV R+ LK LEK
Sbjct: 977 TIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKT 1036
Query: 2912 LKYKEQVETLWPWIDKCQNNLEEIKF-CLDPAEGENSIAKLKSLQKEMDQHFGMVELLNN 2970
+ ++ + + W+ + + E F P E + ++ ++K ++E Q V+LL
Sbjct: 1037 VSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTE 1096
Query: 2971 TANSLLSVCE-IDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESK 3029
+ NS+++ + +E + E ++L + +L+ K LE + + E +++
Sbjct: 1097 SVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKAN 1156
Query: 3030 RQLQCAKEQLDIHDSL-GSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASD 3088
+ L + +L +++ G ++ L L+ + + +Q+ + LAQ L
Sbjct: 1157 KWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRI---LAQTLT----- 1208
Query: 3089 SKGTSDVLL--QVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDD 3146
G D L+ ++ET L ++ + LE +Q + ++ + D
Sbjct: 1209 DGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDK 1268
Query: 3147 ELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIK 3206
+L + DA + ++ + I++ L E ++ EE G +
Sbjct: 1269 QLAAYIADKVDAAQMPQEAQKIQSDLTSHE----------------ISLEEMKKHNQGKE 1312
Query: 3207 RDLEALSKQCNKLLDRAQAREEQVEGTIKRLEE---FYSKLKEFSILLQKAEEHEESQGP 3263
LS+ +D AQ + + V + ++ F +L+E ++L + + H +
Sbjct: 1313 AAQRVLSQ-----IDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALET 1367
Query: 3264 VGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDV 3323
+E E + QLN K + ++ + + V G+ ++Q ++ + + L+ + +
Sbjct: 1368 KSVEQEVVQSQLNHCVNLYKS-LSEVKSEVEMVIKTGRQIVQKK-QTENPKELDERVTAL 1425
Query: 3324 NARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVK 3383
+ L KV +R QL++ L + + + L W+ T+ + + +
Sbjct: 1426 KLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLD 1485
Query: 3384 AQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKA 3443
+++ K Q+ ++ +K ++ I GE + T + + + +LSLL+S W A+ ++A
Sbjct: 1486 SEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETL-VEDKLSLLNSNWIAVTSRA 1544
Query: 3444 ETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALED 3503
E L + F + ++ + +W+ + L E Q E+ + + KA +
Sbjct: 1545 EEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQK--EDVLKRLKAELN 1602
Query: 3504 DIINHNKHLHQAVSIGQSLKVLSSRED--KDMVQSKLD-----FSQVWY-IEIQEKSHSR 3555
DI Q+ ++++R D + +V+ ++ F+ + + I+ + S
Sbjct: 1603 DIRPKVDSTRD-----QAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPL 1657
Query: 3556 SELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQ------QSELRV 3609
EL Q K+ E E+ +N + +K +D EG K+ + R+
Sbjct: 1658 KELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNED--NEGTVKELLQRGDNLQQRI 1715
Query: 3610 LQE---DILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAK 3666
E + + KQ + Q N L+ L+ + L I + K + D+ K D+ K
Sbjct: 1716 TDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEK 1775
Query: 3667 TLEQALQLA--RRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQA-QMRPKELKKEA 3723
L + R++ EL K E+ + + + L + A+ A + +L K
Sbjct: 1776 KLASLPEPRDERKIKEIDRELQK--KKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRW 1833
Query: 3724 KNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNE-RYRLVSDTITQKVEEIDAAIL 3782
+ ++ ++ A + V RE ++ ED V T ++ + A+L
Sbjct: 1834 REIESKFAQFRRLNFAQIHTV----REETMMVMTEDMPLEISYVPSTYLTEITHVSQALL 1889
Query: 3783 RSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDL 3842
+Q A D + K+ SL +I+ Q+S ++ + + L+ ++ +
Sbjct: 1890 EVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERV 1949
Query: 3843 VKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEE 3902
K+ A S+ + Q +K++K+ K+ + E++ + + NQ
Sbjct: 1950 -----KLQEALSQLDFQW--EKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQ------- 1995
Query: 3903 LWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELS 3962
WLTE + + + P E + + ++L++ I + + + +N TG ++++ S
Sbjct: 1996 ---WLTEAEQFLRKTQIP--ENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQS 2050
Query: 3963 PGEGFSI-QEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVER 4021
SI QEK + + + ++ + + R L+E + ++F +++ + LE +
Sbjct: 2051 SKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEE-ADN 2109
Query: 4022 LRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKA 4081
+ P + +++KE++ + K + ++ Q + + L + G ++ + + ++
Sbjct: 2110 IASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEE--QDK 2167
Query: 4082 VQDKLDQMVFIWENIHTLVEER----EAKLLDVMELAEKF-----WCDHMSLIVTIKDTQ 4132
+++KL Q W + + E+ EA++ D+ +L +K +H L++ + +
Sbjct: 2168 LENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNH--LLLWLSPIR 2225
Query: 4133 DFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVK 4192
+ + P + Q+ E A + Q +++ +++ G L +P VK
Sbjct: 2226 NQLEIYNQPNQEGPFDVQETEIA------VQAKQPDVEEILSKGQHLYKE--KPATQPVK 2277
Query: 4193 KSIDELNSAWDSLNKAWKD-----------------------------------RIDKLE 4217
+ +++L+S W ++N+ ++ I KLE
Sbjct: 2278 RKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLE 2337
Query: 4218 EA------MQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEA 4271
+ A + + DW+ + + S + DLE + + I + K +
Sbjct: 2338 MPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDL 2397
Query: 4272 YQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALL 4331
Q++ ++E L A+ L K + + + + D + ++ WD ++E + NR+ +L L
Sbjct: 2398 EQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLK 2457
Query: 4332 ALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAV 4391
Q+ A +E L L K AI+ ++ + L D+ Q+ V+
Sbjct: 2458 DSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVA 2517
Query: 4392 NKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIED 4451
N L+ + ++ + E +N W+++ ++ +R+ L+ R + F ++E
Sbjct: 2518 NDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEK 2577
Query: 4452 LQQWLTDTE------RHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQ 4505
WLT+ E + + L + KE + ++ EA + Y +L + Q
Sbjct: 2578 FLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQ 2637
Query: 4506 QMLARCPKSAE-TNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINW 4564
++L S + + + ++N+ KW + K ++ LE + + H SLQ+ + W
Sbjct: 2638 KILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVW 2697
Query: 4565 LTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQD 4624
L + L+ + V Q D H+ F E+ + I+ +T ++ F +Q
Sbjct: 2698 LQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLET---VRIFLTEQP 2754
Query: 4625 VVLIKNLL-----ISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKL----MEWLE 4675
+ ++ L + + R + V + L RK+A++ + W KL +W
Sbjct: 2755 LEGLEKLYQEPRELPPEERAQNVTRLL----------RKQAEEVNTEWEKLNLHSADWQR 2804
Query: 4676 ESEKSLDSELEIANDPDKIKTQLAQ 4700
+ +++L+ E+ D++ +L Q
Sbjct: 2805 KIDETLERLQELQEATDELDLKLRQ 2829
Score = 226 bits (576), Expect = 5e-58
Identities = 345/1758 (19%), Positives = 713/1758 (40%), Gaps = 172/1758 (9%)
Query: 3339 AQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDD 3398
+ L E+ ++ R+Q ALE +LSW++ E+ + Q S + +VVK Q + L
Sbjct: 209 SSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTA 268
Query: 3399 RKSTVEVIKREGEKIATTAEPA--DKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVV 3456
+ V I + G K+ T + + ++ ++ +Q++LL+SRWE L + + L + +
Sbjct: 269 HQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMD 328
Query: 3457 AQQFHETLEPLNEWLTTIEKRL--VNCEPIGTQASKLEEQIAQHKALEDDI----INHNK 3510
Q ++ L+ LN+WLT E+R + EP+G L+ Q+ QHK L++D+ + N
Sbjct: 329 LQ--NQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNS 386
Query: 3511 HLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFG 3570
H V + +S S ++ +L + I + R LLQ L +
Sbjct: 387 LTHMVVVVDES----SGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLT 442
Query: 3571 EDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLE 3630
E++ WL+E D ++K+ T G Q L LQ+ +L+ LE
Sbjct: 443 EEQCLFSAWLSEKEDAVNKI-----HTTGFKDQNEMLSSLQKLAVLKAD---------LE 488
Query: 3631 LLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLD 3690
KQ+ G + QD L +K + S ++ WLD
Sbjct: 489 KKKQSMGKLYSLKQDLLSTLKNK--------------------------SVTQKTEAWLD 522
Query: 3691 KVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRARE 3750
++ V K E+++ + + + +++++ V++ LV A+E
Sbjct: 523 NF---ARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTREQILVK-HAQE 578
Query: 3751 GLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGD 3810
L ++ ++ D+ +K ++D L SWIT +E L S
Sbjct: 579 ELPP--PPPQKKRQITVDSEIRKRLDVDITELH------------SWITRSEAVLQSPEF 624
Query: 3811 IRLEQDQTSAQLQVQKTFTMEILRHKDI--IDDLVKSGHKIMTACSEE--EKQSMKKKLD 3866
++ + L+ +K +E + + + D +S ++ E S+K+ +
Sbjct: 625 AIFRKEGNFSDLK-EKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASE 683
Query: 3867 KVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYET 3926
++ + CQ+ SER LE +++ F+ ++L T ++ + P E
Sbjct: 684 QLNSRWIEFCQLLSERLNWLEYQNNII-AFYNQLQQLEQMTTTAENWLKIQPTTPSEPTA 742
Query: 3927 LRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKED 3986
++ Q + + ++ +P I+++ L E G F + +VA + Q+ D
Sbjct: 743 IKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMF-LDADFVAFTNHFKQVFSD 801
Query: 3987 VKKRAVALDEAIS--QSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKN 4044
V+ R L ++ + + I +++ +L P + E +++++ E +
Sbjct: 802 VQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQA 861
Query: 4045 VSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEERE 4104
+ +++ Q L +EM S +IS K Q + +++ W+ + + + E
Sbjct: 862 LQSSLQEQQSGLYYLSTTVKEM---SKKAPSEISRK-YQSEFEEIEGRWKKLSSQLVEHC 917
Query: 4105 AKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGI-DPSVVKQQQEAAETIREEID 4163
KL + M K +L + + F+++ E P + D ++K+Q + + +I
Sbjct: 918 QKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKE-EWPALGDSEILKKQLKQCRLLVSDIQ 976
Query: 4164 GLQEELDIVINLGSELIAACGEPD-KPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQA 4222
+Q L+ V N G + I EP+ ++ + ELN+ WD + + R + L+ ++
Sbjct: 977 TIQPSLNSV-NEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEK 1035
Query: 4223 AVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLN 4282
V Q L + +W+ A + + +++ +EE+K+ K EA Q++ +++ L
Sbjct: 1036 TVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLT 1095
Query: 4283 HQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDE 4342
++ + + + ++ L L + L R+ + LE + L++
Sbjct: 1096 ESVNSVIAQAPPVA-QEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEK 1154
Query: 4343 LLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESS 4402
WL E L + + G + I L L+N + + + L +
Sbjct: 1155 ANKWLNEVEFKLKTTENIPGGAEEISEVLDS---LENLMRHSEDNPNQIRILAQTLTDGG 1211
Query: 4403 AGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERH 4462
+E N +LE N RW+ + E+ +R++ L+ +++ A+ + +Q+ LT ++
Sbjct: 1212 VMDELIN--EELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQ 1269
Query: 4463 LLA----SKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETN 4518
L A +P+ A++ + ++ + + EE M+K Q K A
Sbjct: 1270 LAAYIADKVDAAQMPQEAQK---IQSDLTSHEISLEE-----MKKHNQ-----GKEAAQR 1316
Query: 4519 IDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRP 4578
+ I+ ++K + V K F LQ+ L + + L
Sbjct: 1317 VLSQIDVAQKKLQDVSMKF--------RLFQKPANFEQRLQESKMILDEVKMHLPALETK 1368
Query: 4579 SLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSR 4638
S+ + V Q++ ++ + ++ + KTG + Q ++ + + +++
Sbjct: 1369 SVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLH 1428
Query: 4639 WEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQL 4698
+ ++ ++ ER + L+ K +++ + + L EWL ++ L + P + +++
Sbjct: 1429 YNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEV 1488
Query: 4699 AQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVE 4758
A K QK + + + G +L KT L ++D LS L W + ++ E
Sbjct: 1489 AWGKATQKEIEKQKVHLKSITEVGEAL--KTVLGKKETLVEDKLSLLNSNWIAVTSRAEE 1546
Query: 4759 RQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKEL 4818
N L E F + + W+ + + L E + D K + EL
Sbjct: 1547 WLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEK-----KKPQQKEDVLKRLKAEL 1601
Query: 4819 GKRTSSVQALKRSARELIEGSRDD-SSWVKVQMQELSTRWETVCALSISKQTRLEAALRQ 4877
V + + A L+ D V+ Q+ EL+ R+ + K + L++
Sbjct: 1602 NDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAIS--HRIKTGKASIPLKE 1659
Query: 4878 AEEFHSVVHALLEWL-AEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKA 4936
E+F+S + LLE L AE +Q GV +ED + + + ++ +K+L ++ L +
Sbjct: 1660 LEQFNSDIQKLLEPLEAEIQQ-----GVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQR 1714
Query: 4937 TTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIA--KQELL 4994
T R E + +Q Q +AL L + +++ L
Sbjct: 1715 IT------------------------DERKREEIKIKQQLLQTKHNALKDLRSQRRKKAL 1750
Query: 4995 EALLAWLQWAETT------LTDKDKEVI----PQEIEEVKALIAEHQTFMEEMTRKQPDV 5044
E W Q+ L D +K++ P++ ++K + E Q EE+ +
Sbjct: 1751 EISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQA 1810
Query: 5045 DKVTKTYKRRAADPSSLQ 5062
+ +++ A +P+ +Q
Sbjct: 1811 EGLSEDGAAMAVEPTQIQ 1828
Score = 205 bits (521), Expect = 1e-51
Identities = 284/1564 (18%), Positives = 642/1564 (41%), Gaps = 148/1564 (9%)
Query: 3506 INHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCN 3565
++H H Q +++ + + K +S ++Q Y+ + + S
Sbjct: 145 LHHQMHYSQQITVSLAQGYERTSSPKPRFKSYA-YTQAAYVTTSDPTRSPFPSQHLEAPE 203
Query: 3566 AKIFG----EDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQE--------- 3612
K FG E EV L + + + LS L + + + + +++ V+++
Sbjct: 204 DKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYM 263
Query: 3613 -DILLRKQNVDQALLNGLELLK--QTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLE 3669
D+ + V L G +L+ + + DE +Q+++ + +R++ + S + L
Sbjct: 264 MDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLH 323
Query: 3670 QALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKG--EEASQAQMRPKELKKEAKNNK 3727
+ L + + +EL WL K E E + L E+ + + K L+++ + +
Sbjct: 324 RVLMDLQ--NQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQ 381
Query: 3728 ALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQF 3787
++SL + + E A LE+ + +R+ + + + +L+ Q+
Sbjct: 382 VRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRL 441
Query: 3788 DQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGH 3847
+ +W++E E V K T +++ L K
Sbjct: 442 TEEQCLFSAWLSEKEDA-------------------VNKIHTTGFKDQNEMLSSLQKLA- 481
Query: 3848 KIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWL 3907
++ A E++KQSM K LK D + + ++ Q + ++ ++ F ++ L L
Sbjct: 482 -VLKADLEKKKQSMGKLYS--LKQ-DLLSTLKNKSVTQ--KTEAWLDNFARCWDNLVQKL 535
Query: 3908 TETQSIISQLPA---PALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPG 3964
++ + ISQ P+L T+ + +++ +H +++ PQ
Sbjct: 536 EKSTAQISQAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQ--EELPPPPPQ------- 586
Query: 3965 EGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQ 4024
+++ + D+ +++KR LD I++ + + + +L+S E + R
Sbjct: 587 -----KKRQITVDS-------EIRKR---LDVDITELHSWITRSEAVLQSPEFAIFRKE- 630
Query: 4025 PPSISAEVEKIKEQISENKNVSVD-MEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQ 4083
+KE+++ + + KLQ + + E+M+ ++ ++A +++
Sbjct: 631 -----GNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMV------NEGVNADSIK 679
Query: 4084 DKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGI 4143
+Q+ W L+ ER L+ F+ L +++++
Sbjct: 680 QASEQLNSRWIEFCQLLSER-LNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPS 738
Query: 4144 DPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWD 4203
+P+ +K Q + + + GLQ +++ L + IA + P+ +D A+
Sbjct: 739 EPTAIKSQLKICKDEVNRLSGLQPQIE---RLKIQSIALKEKGQGPMF---LDADFVAFT 792
Query: 4204 SLNKAWKDRIDKLEEAMQAA------VQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETV 4257
+ K + E+ +Q ++YQ+ + A+ WV + KL+ TD E +
Sbjct: 793 NHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIM 852
Query: 4258 KQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEE 4317
+Q++ EL+ +S +QQ + L+ + + KK E + Q E++ W L
Sbjct: 853 EQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRK-YQSEFEEIEGRWKKLSS 911
Query: 4318 RIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVL 4377
+++ KLE + L + Q+ + L W+ + L E+ P GD + ++ +L + +L
Sbjct: 912 QLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLL 971
Query: 4378 QNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDG 4437
+D+ Q ++ +VN+ G + + E AS L+ +L+ LN +W ++ ++ RK+ L G
Sbjct: 972 VSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKG 1031
Query: 4438 ALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETY 4497
L + ++ ++ +W+T E L P+ ++ + + KE
Sbjct: 1032 GLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKV 1091
Query: 4498 KSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNS 4557
K L + ++A+ P A+ + +++ L ++ + T+LN + LEE E +
Sbjct: 1092 KLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSY 1151
Query: 4558 LQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLK 4617
L+ WL + E L + + +D + + QI L +T T
Sbjct: 1152 LEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTDGG 1211
Query: 4618 YFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEES 4677
+ LI L + SRW ++ + V R + L+ + + A++ ++ + E L
Sbjct: 1212 VMDE-----LINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFI 1266
Query: 4678 EKSLDSEL-------EIANDPDKIKTQLAQH----KEFQKSLGAKHSVYDTTNRTGRSLK 4726
+K L + + ++ + KI++ L H +E +K K + ++ + K
Sbjct: 1267 DKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQK 1326
Query: 4727 EKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYR 4786
KL D+ + R + K + +L+E+ + + L AL
Sbjct: 1327 ----------KLQDVSMKFR-----LFQKPANFEQRLQESKMILDEVKMHLPAL------ 1365
Query: 4787 VEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSR-DDSSW 4845
E + E + V ++ +NL K L + S V+ + ++ R++++ + ++
Sbjct: 1366 -ETKSVEQEVVQSQLNHCVNL-------YKSLSEVKSEVEMVIKTGRQIVQKKQTENPKE 1417
Query: 4846 VKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVL 4905
+ ++ L + + A ++ +LE L+ + + ++ L EWLA + L +
Sbjct: 1418 LDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAV 1477
Query: 4906 PDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRAR 4965
L + + K K++E+++ L T +G+ + + T ++ ++++ +
Sbjct: 1478 EGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKE-TLVEDKLSLLNSN 1536
Query: 4966 FEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKA 5025
+ V + A++ L + + ++ + W+ A+T L + +K+ Q+ + +K
Sbjct: 1537 WIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKR 1596
Query: 5026 LIAE 5029
L AE
Sbjct: 1597 LKAE 1600
Score = 184 bits (467), Expect = 2e-45
Identities = 494/2698 (18%), Positives = 1056/2698 (39%), Gaps = 384/2698 (14%)
Query: 1210 KLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVF 1269
KLK +N L T+ T+ EEE + D +++ + K + ++++++
Sbjct: 333 KLKELNDWLTKTEE--------RTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRV 384
Query: 1270 HALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIG 1329
++L + + DE + L+ E+ L +RW N+ ++R L+ I
Sbjct: 385 NSLTHMV----VVVDESSGDHATAALE-----EQLKVLGDRWANICRWTEDRWVLLQDI- 434
Query: 1330 KSLKYYRDTYHP--LDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSK 1387
LK+ R T W+ + E KI ++ + + L + +L +++E K+
Sbjct: 435 -LLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQS 493
Query: 1388 MDECQKYAEQYSATVKDYELQTMT------YRAMVDSQQKSPVKRRRMQSSADLIIQEFM 1441
M + + +T+K+ + T + D+ + K S A Q +
Sbjct: 494 MGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSL 553
Query: 1442 DLRTRYTALVTLMTQ---YIKFAGDSLKRLEEEEK---SLEEEKKEHVE-KAKELQKWVS 1494
T + T+ T+ +K A + L ++K +++ E ++ ++ EL W++
Sbjct: 554 TQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWIT 613
Query: 1495 NISKTLKDAE-----KAGKPPFSKQKISS--EEISTKKEQLSEALQTIQLFLAKHGD--- 1544
L+ E K G K+K+++ E + K +L +A ++ Q + + +
Sbjct: 614 RSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGV 673
Query: 1545 -----KMTDEERNE--------LEKQVKTLQESYNLL-FSESLKQLQESQTSGD--VKV- 1587
K E+ N L +++ L+ N++ F L+QL++ T+ + +K+
Sbjct: 674 NADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQ 733
Query: 1588 -----EEKIVAERQQEYKEKLQGICDLLTQTENRLI--------GHQEAFMIGDGTVELK 1634
E + + + K+++ + L Q E I G F+ D
Sbjct: 734 PTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTN 793
Query: 1635 KY-------QSKQEELQKDM--------QGSAQALAEVVKNTENFLKENGEKLSQEDKAL 1679
+ Q++++ELQ Q + A+ V+ +E K + +LS D +
Sbjct: 794 HFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSET--KLSIPQLSVTDYEI 851
Query: 1680 IEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDW 1739
+EQ+L E ++ Q +L+ +QS ++T +KE ++K + E K ++ +
Sbjct: 852 MEQRLGE--LQALQSSLQEQQSGLYY---LSTTVKEMSKKAPS-----EISRKYQSEFEE 901
Query: 1740 LSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQEN 1799
+ K +H Q +E+ Q + + + E DV +
Sbjct: 902 IEGRWKKLSSQLVEHCQKLEE-----QMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALG 956
Query: 1800 LNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYE 1859
++ +K Q ++S Q + + S +K PE +L+ +KEL ++
Sbjct: 957 DSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWD 1016
Query: 1860 TALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKR 1919
+ + + E+ D +E W+ Q+E+E + + L ++
Sbjct: 1017 HMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEE 1076
Query: 1920 QKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRF 1979
K E+ + ++ +T S N V+ A ++ ++++L+ T +
Sbjct: 1077 MKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQ------------EALKKELETLTTNY 1124
Query: 1980 RSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQ 2039
+ L C L K L + + + + LL+ L+ A+K L+E ++ +
Sbjct: 1125 QWL---CTRLNGKCKTLEEVWACWHE----LLSYLE----KANKWLNE--------VEFK 1165
Query: 2040 LEETKALQG---QISSQQVAVEKLKKTAEVLLDARGSLLPAKND-------IQKTLDDIV 2089
L+ T+ + G +IS ++E L + +E + L D I + L+
Sbjct: 1166 LKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTDGGVMDELINEELETFN 1225
Query: 2090 GRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLK-------EQGQVPL 2142
R+ +L + R + L+ ++ + + L + + + ++ L + Q+P
Sbjct: 1226 SRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQ 1285
Query: 2143 NSTALQ-DIISKNIMLEQ---DIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLS 2198
+ +Q D+ S I LE+ G++++ +++ + D S L K +
Sbjct: 1286 EAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFE 1345
Query: 2199 ARFSEASHKHKETLAKMEELKTK--------------VELFENLSE---KLQTFLETKTQ 2241
R E+ E + L+TK V L+++LSE +++ ++T Q
Sbjct: 1346 QRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQ 1405
Query: 2242 ALTEVDVP-------------------GKDVTELSQYMQESTSEFLEHKKHLEVL----- 2277
+ + G VTE Q +++ + +K + VL
Sbjct: 1406 IVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLA 1465
Query: 2278 ---HSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVL 2334
L K + G+PS+ + K+ ++ + +K E + + L + L
Sbjct: 1466 ATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETL 1525
Query: 2335 VKSLKS-----WIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSG 2389
V+ S WI T++ AE+ L + +K E + I K
Sbjct: 1526 VEDKLSLLNSNWIAVTSR----------AEEWLNLLLEYQKHMETFDQNVDHITKWIIQA 1575
Query: 2390 ISLCNLISAVTTPAKAIAAVKSGGAVLNG-----EGTATNTEEFWANKGLTSIKKDMTDI 2444
+L + S P + +K A LN + T AN+G
Sbjct: 1576 DTLLD-ESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRG----------- 1623
Query: 2445 SHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEA 2504
+ L++ +I+ELN + + + + A + L+++ + + Q+ P + E
Sbjct: 1624 ----DHCRKLVEPQISELNHRFAAISHRIKTGKASIP-LKELEQFNSDIQKLLEPLEAEI 1678
Query: 2505 VKTQVEQNKSFEAELKQ-NVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQEL 2563
+ + + F ++ + N V+EL + L + D + K + +K L
Sbjct: 1679 QQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNAL 1738
Query: 2564 NQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQ 2623
L R++K E S+ Q++ L + L + E ++ L P D + +++Q
Sbjct: 1739 KDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASL-PEPRDERKIKEIDRELQ 1797
Query: 2624 ILLQEFATRKPQYEQLTAAGQGILSRP-------------GEDPSLRGIVKEQLAAVTQK 2670
+E + Q E L+ G + P + R + Q+ V ++
Sbjct: 1798 KKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREE 1857
Query: 2671 WDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQL 2730
T + ++ + V ST Y + + +S L +++ L++ + + + +Q
Sbjct: 1858 ----TMMVMTEDMPLEISYVPST-YLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQE 1912
Query: 2731 ETAQKMKQEIQQEKKQIKVAQALCEDLSAL--------VKEEYLKAELSRQLEGILKSFK 2782
E+ + +K +QQ +I + + + +AL VK + ++L Q E + K +K
Sbjct: 1913 ESLKNIKDSLQQSSGRIDIIHS--KKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYK 1970
Query: 2783 DVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSH-PISAKLDVLESLIK 2841
D + + + V+ + F Q + + +L + +N H L L+ I
Sbjct: 1971 DRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKELQDGIG 2030
Query: 2842 DHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERE 2901
+ +TL A GE ++ ++ ++ + LQ +L ++ W KQ+ +R+
Sbjct: 2031 QRQTVVRTLN----------ATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRK 2080
Query: 2902 NKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGE---NSIAKLKSLQKEM 2958
+L+E +++ + W+++ +N+ I L+P + + + ++K L +E+
Sbjct: 2081 KRLEEQKNILSEFQRDLNEFVLWLEEA-DNIASIP--LEPGKEQQLKEKLEQVKLLVEEL 2137
Query: 2959 DQHFGMVELLNNTANSLLSVCEIDKEVVTD-ENK-------------------------- 2991
G+++ LN T +L I E ENK
Sbjct: 2138 PLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQI 2197
Query: 2992 ----SLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKE-----SKRQLQCAKEQLDIH 3042
L +K++ + EQL+ L + + + + + ++E + ++ +Q D+
Sbjct: 2198 KDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVE 2257
Query: 3043 DSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASD---------SKGTS 3093
+ L + K Q ++ L+ L + RL Q+L + D + T
Sbjct: 2258 EILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQ 2317
Query: 3094 DVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAP 3153
V L + + + + +S+ E S L ++ + F E+ + D + S
Sbjct: 2318 TVTLVTQPVVTKETAISKL--EMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRV 2375
Query: 3154 VGRDAETLQ----KQKETIKAFLKK---LEALMASNDN-ANKTCKMMLATEETSPDLVGI 3205
+ D E + KQK T++ ++ LE L+ + N NKT T T
Sbjct: 2376 MVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITD------ 2429
Query: 3206 KRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVG 3265
+E + Q +++ + Q R +Q+ +K ++ +E +L +A ES
Sbjct: 2430 --RIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGP 2487
Query: 3266 METETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNA 3325
+ I +++ K K ++ Q N L L++ + + T+ + +++NA
Sbjct: 2488 YTVDAIQKKITETKQLAK-DLRQWQTNVDVANDLALKLLRDYS-ADDTRKVHMITENINA 2545
Query: 3326 RWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELV-----ANQKPPSAE-F 3379
W++++K+V++R A L+E +F LE L+W+ + E A +K E
Sbjct: 2546 SWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDS 2605
Query: 3380 KVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKIL-KQLSLLDSRWEA 3438
K VK +++ + LQ ++ + +KI + E +D +L ++L ++ +W
Sbjct: 2606 KGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSE 2665
Query: 3439 LLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQH 3498
L K+ LE S ++ H +L+ L WL + L PIG +++Q H
Sbjct: 2666 LRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVH 2725
Query: 3499 KALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSEL 3558
+A + ++ + +S +++++ + + + ++ + + + +E++ + + L
Sbjct: 2726 RAFKRELKTKEPVI---MSTLETVRIFLTEQPLEGLEKL--YQEPRELPPEERAQNVTRL 2780
Query: 3559 LQQALCNAKIFGED-EVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLR 3617
L++ E + +W ++ + L +L +T+ L +L++ Q +++
Sbjct: 2781 LRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDEL-----DLKLRQAEVIKG 2835
Query: 3618 K-QNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQL 3674
Q V L++ L QD LE +KA +I L +V+ + A QL
Sbjct: 2836 SWQPVGDLLIDSL--------------QDHLEKVKALRGEIAPLKENVSHVNDLARQL 2879
Score = 104 bits (259), Expect = 3e-21
Identities = 49/110 (44%), Positives = 73/110 (66%), Gaps = 2/110 (1%)
Query: 189 EDMSAKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAV-QS 247
+ ++++ LL W +Q+T Y + NFTT W DG NA+IH +RPDL D N+V QS
Sbjct: 9 QQTNSEKILLSWVRQSTRNYPQVNVINFTTSWSDGLALNALIHSHRPDLFDWNSVVCQQS 68
Query: 248 NLANLEHAFYVAE-KIGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAFPK 296
LEHAF +A ++G+ +LLDPEDVD + PD+KS++ Y++SL+ P+
Sbjct: 69 ATQRLEHAFNIARYQLGIEKLLDPEDVDTTYPDKKSILMYITSLFQVLPQ 118
Score = 38.9 bits (89), Expect = 0.14
Identities = 46/168 (27%), Positives = 73/168 (43%), Gaps = 27/168 (16%)
Query: 648 VQDLLNWVDEMQVQLDR-TEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMT 706
+Q+LL W+ +L R G D P+V+ +VHRA + E KE I T
Sbjct: 2691 LQELLVWLQLKDDELSRQAPIGGDFPAVQKQ----NDVHRAFKR-ELKTKEPVIMSTLET 2745
Query: 707 APLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYD 766
+ LT + L LE Y + R L RA N + L K+ EEV +
Sbjct: 2746 VRIFLT-EQPLEGLEKLY--------QEPRELPP----EERAQN-VTRLLRKQAEEVNTE 2791
Query: 767 WSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARL 814
W + N + A+ R++D+ E ++ +QE ++L L+ A +
Sbjct: 2792 WEKLNL-------HSADWQRKIDETLERLQELQEATDELDLKLRQAEV 2832
>gi|5032287 dystrophin Dp427p1 isoform [Homo sapiens]
Length = 3681
Score = 325 bits (832), Expect = 1e-87
Identities = 545/2835 (19%), Positives = 1126/2835 (39%), Gaps = 316/2835 (11%)
Query: 2230 EKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHL-----------EVLH 2278
++ QT LE L + + E+S ++ +F H+ ++ +L
Sbjct: 338 DRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNILQ 397
Query: 2279 SLLKEISSHGLPSDKAL-VLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKS 2337
K I + L D+ V E+ N L+ +++ + EK+ + + +D +K
Sbjct: 398 LGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLH--RVLMDLQNQKLKE 455
Query: 2338 LKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLIS 2397
L W+ +T ++ ++ E LG LED K+ ++ + ++++ SL +++
Sbjct: 456 LNDWLTKTEERTRKMEE----EPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVV 511
Query: 2398 AVTTPA--KAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLL 2455
V + A AA++ VL WAN I ED +LL
Sbjct: 512 VVDESSGDHATAALEEQLKVLGDR---------WAN------------ICRWTEDRWVLL 550
Query: 2456 KDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSF 2515
+D L K Q+ EE WL + K T E + + +++
Sbjct: 551 QDI-------LLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSS-LQKLAVL 602
Query: 2516 EAEL---KQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEI-DSKWQELNQLTIDRQ 2571
+A+L KQ++ K+ LK L L+ T + W D+ Q+L + T
Sbjct: 603 KADLEKKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQIS 662
Query: 2572 QKLEESSNNLTQFQTVEA------------------------------------------ 2589
Q + + +LTQ +E
Sbjct: 663 QAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDV 722
Query: 2590 ---QLKQWLVEKELMV-SVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQG 2645
+L W+ E ++ S + + +++V + +E A + + + + + Q
Sbjct: 723 DITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQA 782
Query: 2646 ILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDK 2705
++ + + +K+ + +W LS+R +W++ + + L+ L
Sbjct: 783 LVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQN-NIIAFYNQLQQLEQM 841
Query: 2706 LSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEE- 2764
+ +N L + P A+ QL+ + + + QI+ + S +KE+
Sbjct: 842 TTTAENWLKIQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQ----SIALKEKG 897
Query: 2765 ----YLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKK 2820
+L A+ + F DV+ + E +Q + ++Q+ + W+ +
Sbjct: 898 QGPMFLDADFVAFTNHFKQVFSDVQAR-EKELQTIFDTLPPM-RYQETMSAIRTWVQQSE 955
Query: 2821 EEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQ 2880
+ + +++E + + + +L Q + + K Q
Sbjct: 956 TKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQ 1015
Query: 2881 LQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLD 2940
+ I+ W + Q+ E KL+E + K K + ++TL W+ + L+E
Sbjct: 1016 SEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEW---- 1071
Query: 2941 PAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTD-----------E 2989
PA G++ I L+K++ Q +V + SL SV E +++ + E
Sbjct: 1072 PALGDSEI-----LKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETE 1126
Query: 2990 NKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQA 3049
K L + D + +Q++++K L+ +K Q+ E + A+E+ D
Sbjct: 1127 LKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERD------ 1180
Query: 3050 YSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTL 3109
+ K LQ + ++ K + K L+ E+ +S + E + +E TL
Sbjct: 1181 FEYKTPDELQKAVEEMKRAKEEAQ-QKEAKVKLLTESVNSVIAQAPPVAQEALKKELETL 1239
Query: 3110 SQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIK 3169
+ C+ L K + + E+ S + + L+ + + E + E I
Sbjct: 1240 TTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEIS 1299
Query: 3170 AFLKKLEALMA-SNDNANKTCKMMLATEETSPDLVG--IKRDLEALSKQCNKLLDRAQAR 3226
L LE LM S DN N+ +LA T ++ I +LE + + +L + A R
Sbjct: 1300 EVLDSLENLMRHSEDNPNQI--RILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRR 1357
Query: 3227 EEQVEGTIKRLEEFYSKL---KEFSILLQK------AEEHEESQGPVGMETETINQQLNM 3277
++ +E +I+ +E L +E + K A++ + +Q P E + I L
Sbjct: 1358 QKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMP--QEAQKIQSDLTS 1415
Query: 3278 FKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQR 3337
++ +E + QGK+ L Q I A K L DV+ +++ L +K A
Sbjct: 1416 HEISLEEMKKHNQGKEAAQRVLSQ--IDVAQKK---------LQDVSMKFR-LFQKPANF 1463
Query: 3338 AAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLD 3397
+LQE+ + + L +L + S E +VV++Q+ L + L
Sbjct: 1464 EQRLQESKMILDEVKMHLPAL--------------ETKSVEQEVVQSQLNHCVNLYKSLS 1509
Query: 3398 DRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVA 3457
+ KS VE++ + G +I + + ++ ++++ L + L K R +QLE ++
Sbjct: 1510 EVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLS 1569
Query: 3458 QQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVS 3517
++ + + L EWL + L + S L+ ++A KA + +I HL
Sbjct: 1570 RKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITE 1629
Query: 3518 IGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELM 3577
+G++LK + +++ +V+ KL +I + ++ LL + + + F ++ +
Sbjct: 1630 VGEALKTVLGKKET-LVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHIT 1688
Query: 3578 NWLNEVHDKL--SKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQT 3635
W+ + L S+ + L + ++EL ++ + + + N + ++
Sbjct: 1689 KWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKL 1748
Query: 3636 TGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVE 3695
++ + + AI R K T ++ K LEQ ++L L+ +E E
Sbjct: 1749 VEPQISELNHRFAAISHRIK--TGKASIPLKELEQFNSDIQKL----------LEPLEAE 1796
Query: 3696 LLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKM 3755
+ + LK E+ + K++ ++ N + + L + + R RE ++
Sbjct: 1797 I--QQGVNLKEEDFN------KDMNED--NEGTVKELLQRGDNLQQRITDERKREEIKIK 1846
Query: 3756 VAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQ 3815
++ + D +Q+ ++ + Q+ + AD L + + EKKL SL + R E+
Sbjct: 1847 QQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDER 1906
Query: 3816 D--QTSAQLQVQKTFTMEILRHKDII--DDLVKSGHKIMTACSEEEKQSMKKKLDKVLKN 3871
+ +LQ +K + R + + D + S+ ++ K N
Sbjct: 1907 KIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLN 1966
Query: 3872 YDTICQINSERYLQLERAQSL-VNQFWETY----EELWPWLTETQSIISQLPAPALEYET 3926
+ I + E + + L ++ TY + L E + +++ A ++E
Sbjct: 1967 FAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFED 2026
Query: 3927 LRQQQEEHRQLRELIAEHKPHIDKMN-KTGPQLLELSPGEGFSIQEKYVAADTLYSQIKE 3985
L +Q+E + +++ + + ID ++ K L +P E +QE D + ++ +
Sbjct: 2027 LFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNK 2086
Query: 3986 DVKKRAVALDEAISQSTQFHDKI---DQILESLERIVERLRQPPSISAEVEKIKEQISEN 4042
K R D ++ + +FH I +Q L E+ + + + P + E K K + E
Sbjct: 2087 MYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENW--EHAKYKWYLKEL 2144
Query: 4043 KNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEE 4102
++ + + Q + TL GEE+I +S TD I +Q+KL + W+ + + +
Sbjct: 2145 QD---GIGQRQTVVRTLNATGEEIIQQSSKTDASI----LQEKLGSLNLRWQEVCKQLSD 2197
Query: 4103 REAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEI 4162
R+ +L + + +F D ++ +++ + +PG + + K++ E + + EE+
Sbjct: 2198 RKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQL-KEKLEQVKLLVEEL 2256
Query: 4163 DGLQEELDIVINLGSELIAACG----EPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEE 4218
Q L + G ++ + E DK ++ + + N W +++A ++ ++E
Sbjct: 2257 PLRQGILKQLNETGGPVLVSAPISPEEQDK--LENKLKQTNLQWIKVSRALPEKQGEIEA 2314
Query: 4219 AMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEE----LKQFKSEAYQQ 4274
++ Q + L+ D + L +SPI LE Q +E +++ + +
Sbjct: 2315 QIKDLGQLEKKLE---DLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAK 2371
Query: 4275 QIEMERLNHQAELLLK-KVTEESDKHTVQDPLMELKLIWDSLEER--------------- 4318
Q ++E + + + L K K + K ++D E K + L+E
Sbjct: 2372 QPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIG 2431
Query: 4319 -------------IINRQ---HKLE--GALL----ALGQFQHALDELLAWLTHTEGLLSE 4356
++ ++ KLE +L+ AL F A EL WL+ + ++
Sbjct: 2432 ASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKS 2491
Query: 4357 QKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNL-QNKLE 4415
Q+ + GD + I + K D+ + +E + A +L ++ +EA + +++E
Sbjct: 2492 QRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIE 2551
Query: 4416 VLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPET 4475
+ +W V E + R+QQL+ L+ + + E+ +Q L L + K +
Sbjct: 2552 RIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDA 2611
Query: 4476 AKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVET 4535
++++ ++ + ++L + N+ W S+
Sbjct: 2612 IQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHK 2671
Query: 4536 KLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNV---ASRPSLILDT---VLFQI 4589
+++ER+ LEE L +F L+ F+ WLT+AE T NV A+R +L+ V +
Sbjct: 2672 RVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELM 2731
Query: 4590 DEHKVFANEVNSHREQIIELDKTGTH-LKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVE 4648
+ + E+ +H + LD+ L+ D VL++ L ++ +W ++ ++ +
Sbjct: 2732 KQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLN 2791
Query: 4649 RGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSL 4708
L+ + + K+ H + +L+ WL+ + L + I D ++ Q H+ F++ L
Sbjct: 2792 IRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKREL 2851
Query: 4709 GAKHSVYDTTNRT-------------------GRSLKEKTSLADDNLKLDDMLSELRDKW 4749
K V +T T R L + + L E+ +W
Sbjct: 2852 KTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEW 2911
Query: 4750 DTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGD--IDLVMNL 4807
+ + S + Q K++E L + +A L L + E QPV GD ID + +
Sbjct: 2912 EKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPV-GDLLIDSLQDH 2970
Query: 4808 IDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISK 4867
++ KA + E+ +V + AR+L S + +++L+TRW+ +
Sbjct: 2971 LEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLL------- 3023
Query: 4868 QTRLEAALRQAEEFH 4882
Q +E +RQ E H
Sbjct: 3024 QVAVEDRVRQLHEAH 3038
Score = 316 bits (809), Expect = 5e-85
Identities = 548/2809 (19%), Positives = 1128/2809 (40%), Gaps = 353/2809 (12%)
Query: 1879 LEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYIT 1938
L+++ E WL +E L+ ++D+ + + + + D+ +H+G + I
Sbjct: 337 LDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNIL 396
Query: 1939 ISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVD 1998
G++++ K + EVQ +++ R+ L +NL ++
Sbjct: 397 QLGSKLIGTGKLSEDEE----------TEVQEQMNLLNSRWECLRVASMEKQSNLHRVLM 446
Query: 1999 KYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVE 2058
Q+ + L L E K EP+ D ++L+RQ+++ K LQ + +QV V
Sbjct: 447 DLQNQKLKE--LNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVN 504
Query: 2059 KLKKTAEVLLDARGSLLPAKNDIQ-KTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQ 2117
L V+ ++ G A + Q K L D R+ ++ + +R LQ L + +
Sbjct: 505 SLTHMVVVVDESSGDHATAALEEQLKVLGD---RWANICRWTEDRWVLLQDILLKWQRLT 561
Query: 2118 DGLDEMLDWMGNVESSLKEQGQVPLNSTALQD------IISKNIMLEQDIAGRQSSINAM 2171
+ W+ E ++ + +++T +D + K +L+ D+ ++ S+ +
Sbjct: 562 EEQCLFSAWLSEKEDAVNK-----IHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKL 616
Query: 2172 NEKVKKFMETT-DPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSE 2230
+ + T + S +A + + + + K +++ A++ + T + +L++
Sbjct: 617 YSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQ--PSLTQ 674
Query: 2231 KLQTFLETKTQALTEVDVPGKDVTEL-----SQYMQESTSEFLEHKKHLEV----LHSLL 2281
T +ET T T + K E Q ++ T + E +K L+V LHS +
Sbjct: 675 T--TVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDS-EIRKRLDVDITELHSWI 731
Query: 2282 KEISSHGLPSDKALVLEKTNNLS--------------KKFKEMEDTIKEKK--------- 2318
S L S + + K N S +KF++++D + +
Sbjct: 732 TR-SEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNE 790
Query: 2319 ----EAVTSCQEQLDA----FQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKK 2370
+++ EQL++ F L+ +W++ + E + + E+ K
Sbjct: 791 GVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLK 850
Query: 2371 LQEKWSLKTPEIQKVNNSGISLC-NLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFW 2429
+Q TP S + +C + ++ ++ I +K L +G
Sbjct: 851 IQPT----TPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKG--------- 897
Query: 2430 ANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKL--QKAQEESSAMMQWLQKMN 2487
+G + D ++ ++ + ++ + EL T L + QE SA+ W+Q+ +
Sbjct: 898 --QGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQ-S 954
Query: 2488 KTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAP 2547
+T Q TD E ++ ++ + ++ ++ L++ + + L + E+ ++ P + +
Sbjct: 955 ETKLSIPQLSV-TDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAP-SEISR 1012
Query: 2548 RWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGP 2607
+++ EI+ +W++L+ ++ QKLEE N L + Q LK+W+ E ++ + P
Sbjct: 1013 KYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWP 1072
Query: 2608 LSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAV 2667
D +L Q +Q ++L+ + T +P + GQ I + +P ++ +L +
Sbjct: 1073 ALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEA--EPEFASRLETELKEL 1130
Query: 2668 TQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMN 2727
+WD + Q+ R + + + K+ Q L + + ++ + + PD +
Sbjct: 1131 NTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQ 1190
Query: 2728 QQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAE--LSRQLEGILKSFKDVE 2785
+ +E ++ K+E QQ++ ++K+ L E +++++ + A+ L ++LE + +++ +
Sbjct: 1191 KAVEEMKRAKEEAQQKEAKVKL---LTESVNSVIAQAPPVAQEALKKELETLTTNYQWLC 1247
Query: 2786 QKAENHVQHLQSACASSHQFQQMSRDFQAWLD-------TKKEEQNKSHPISAKLDVLES 2838
+ + L+ A H+ WL+ T + + IS LD LE+
Sbjct: 1248 TRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLEN 1307
Query: 2839 LIKDHKD-------FSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQ--------- 2882
L++ +D ++TLT M E E E + + + A++ Q
Sbjct: 1308 LMRHSEDNPNQIRILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQS 1367
Query: 2883 -------LNTIKTNWDTFNKQVK-------------ERENKLKE-------SLEKALKY- 2914
L+ I+ + +KQ+ + K++ SLE+ K+
Sbjct: 1368 AQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHN 1427
Query: 2915 --KEQVETLWPWIDKCQNNLEEI--KFCL--DPAEGENSIAKLKSLQKEMDQHFGMVEL- 2967
KE + + ID Q L+++ KF L PA E + + K + E+ H +E
Sbjct: 1428 QGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETK 1487
Query: 2968 ----------LNNTANSLLSVCEIDKEV--VTDENKSLIQKVDMVTEQLHSKKFCLENMT 3015
LN+ N S+ E+ EV V + ++QK +Q + K E +T
Sbjct: 1488 SVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQK-----KQTENPKELDERVT 1542
Query: 3016 QKFKEFQEVSK---ESKRQLQ-CAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQ 3071
+ E+ E K+QL+ C K + + M T++ +++ +
Sbjct: 1543 ALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSN 1602
Query: 3072 VDL----AKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGI 3127
+D K +++ + K ++V ++T+ + TL V++K S L + +
Sbjct: 1603 LDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETL---VEDKLSLLNSNWIAV 1659
Query: 3128 G----HFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASND 3183
+ N + E FD +D + A+TL + E K K+ + L
Sbjct: 1660 TSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKE-DVLKRLKA 1718
Query: 3184 NANKTCKMMLATEETSPDLVGIKRD--LEALSKQCNKLLDRAQAREEQVEG-----TIKR 3236
N + +T + + +L+ + D + + Q ++L R A +++ +K
Sbjct: 1719 ELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKE 1778
Query: 3237 LEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDV 3296
LE+F S +++ LL+ E E Q V ++ E N+ +N E +G +++
Sbjct: 1779 LEQFNSDIQK---LLEPLEA--EIQQGVNLKEEDFNKDMN----------EDNEGTVKEL 1823
Query: 3297 NWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALE 3356
G L Q + ++ + + L +QR + E +++ +
Sbjct: 1824 LQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQAD 1883
Query: 3357 SLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKI--- 3413
LL + D E+ +A+ P E K+ K + R L +K + ++R+ E +
Sbjct: 1884 DLLKCLDDIEKKLASLPEPRDERKI--------KEIDRELQKKKEELNAVRRQAEGLSED 1935
Query: 3414 --ATTAEPADKVKILKQLSLLDSRWEAL--LNKAE------------TRNRQLEGISVVA 3457
A EP ++++ K+ ++S++ LN A+ T + LE IS V
Sbjct: 1936 GAAMAVEPT-QIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLE-ISYVP 1993
Query: 3458 QQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHL---HQ 3514
+ + +++ L +E+ L + L +Q K ++D + + + H
Sbjct: 1994 STYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHS 2053
Query: 3515 AVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEV 3574
+ R S+LDF + ++ + R +++ + F D
Sbjct: 2054 KKTAALQSATPVERVKLQEALSQLDFQ---WEKVNKMYKDRQGRFDRSVEKWRRFHYDIK 2110
Query: 3575 ELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQ 3634
WL E L K + + +K L+ LQ+ I R+ V G E+++Q
Sbjct: 2111 IFNQWLTEAEQFLRKTQIPENWEHAKYKWY--LKELQDGIGQRQTVVRTLNATGEEIIQQ 2168
Query: 3635 TTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEV 3694
++ + I+Q+KL ++ R++++ K +D K LE+ + E WL++ +
Sbjct: 2169 SSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEAD- 2227
Query: 3695 ELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREG--L 3752
+ S + K ++ + + K L +E + +L LNE +L P E L
Sbjct: 2228 NIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKL 2287
Query: 3753 EKMVAEDNERYRLVSDTITQKVEEIDAAIL-------RSQQFDQAADAELSWITETEKKL 3805
E + + N ++ VS + +K EI+A I + + ++ + L W++ +L
Sbjct: 2288 ENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQL 2347
Query: 3806 MSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKL 3865
Q VQ+T + D+ + L K H + Q +K+KL
Sbjct: 2348 EIYN-----QPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYK---EKPATQPVKRKL 2399
Query: 3866 DKVLKNYDTICQINSE-RYLQLERAQ-------------SLVNQFWETYEELWPWLTETQ 3911
+ + + + ++ E R Q + A +LV Q T E L
Sbjct: 2400 EDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPS 2459
Query: 3912 SIISQLPAPA--------------LEYETLRQQQE---EHRQLRELIAEHKPHIDKMNKT 3954
S++ ++PA A L + ++ Q+ + + E+I + K + + +
Sbjct: 2460 SLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQR 2519
Query: 3955 GPQLLEL-----------SPGEGFSI-QEKYVAADTLYSQIKEDVKKRAVALDEAISQST 4002
PQL EL S E +I ++ + +++E ++ R L+E + ST
Sbjct: 2520 RPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDST 2579
Query: 4003 QF---HDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETL 4059
Q+ ++ +Q+L +E ++ P V+ I+++I+E K ++ D+ + Q +
Sbjct: 2580 QWLEAKEEAEQVLGQARAKLESWKEGPYT---VDAIQKKITETKQLAKDLRQWQTNVDVA 2636
Query: 4060 KQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWC 4119
+++ R D + + ++ W +IH V EREA L + L ++F
Sbjct: 2637 NDLALKLL-RDYSADDTRKVHMITENINAS---WRSIHKRVSEREAALEETHRLLQQFPL 2692
Query: 4120 DHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEEL----DIVINL 4175
D + + + + L+D +++ + E +++ D LQ E+ D+ NL
Sbjct: 2693 DLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQD-LQGEIEAHTDVYHNL 2751
Query: 4176 GSE----LIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQ 4231
L + G D ++++ +D +N W L K + LE + + LQ
Sbjct: 2752 DENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQ 2811
Query: 4232 AVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAY------------------Q 4273
+ W+ + +L+ +PIG D V++Q + + FK E +
Sbjct: 2812 ELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTE 2871
Query: 4274 QQIE-MERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLA 4332
Q +E +E+L + L + ++ ++ E+ W+ L + Q K++ L
Sbjct: 2872 QPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLER 2931
Query: 4333 LGQFQHALDELLAWLTHTEGLLSEQKPVGG-DPKAIEIELAKHHVLQNDVLAHQSTVEAV 4391
L + Q A DEL L E + +PVG +++ L K L+ ++ + V V
Sbjct: 2932 LQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHV 2991
Query: 4392 NKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALR 4440
N L NL + LE LN RW+ + E R +QL A R
Sbjct: 2992 NDLARQLTTLGIQLSPYNL-STLEDLNTRWKLLQVAVEDRVRQLHEAHR 3039
Score = 313 bits (803), Expect = 2e-84
Identities = 505/2706 (18%), Positives = 1066/2706 (39%), Gaps = 308/2706 (11%)
Query: 2413 GAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKA 2472
G+ L G G + EE T +++ M ++ +E L + +K + L+ L LQ
Sbjct: 399 GSKLIGTGKLSEDEE-------TEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQN- 450
Query: 2473 QEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDK 2532
++ + WL K + K ++ P D E +K QV+Q+K + +L+Q +V L
Sbjct: 451 -QKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHM 509
Query: 2533 LTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLK 2592
+ + E + D A +Q L + +W + + T DR L++ + +
Sbjct: 510 VVVVDESSGDHATAALEEQ-LKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFS 568
Query: 2593 QWLVEKELMVSVLGPLSI-DPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPG 2651
WL EKE V+ + D N + + Q++ +L + +K +L + Q +LS
Sbjct: 569 AWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTL- 627
Query: 2652 EDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKS-----------------TQ 2694
++ S+ + L + WD+L +L I QA+ + T+
Sbjct: 628 KNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTR 687
Query: 2695 YQSLLRSLSDKLSD----------LDNKLSSSLAVS--------THPDAMNQQLETAQKM 2736
Q L++ ++L +D+++ L V T +A+ Q E A
Sbjct: 688 EQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFR 747
Query: 2737 KQ-----------EIQQEKKQ--------IKVAQALCEDL-SALVKEEYLKAELSRQLEG 2776
K+ I++EK + + AQAL E + + V + +K + S QL
Sbjct: 748 KEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIK-QASEQLNS 806
Query: 2777 ILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPIS-AKLDV 2835
F + + N +++ + A +Q QQ+ + + T E K P + ++
Sbjct: 807 RWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQ-----MTTTAENWLKIQPTTPSEPTA 861
Query: 2836 LESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNK 2895
++S +K KD L+ E+ + +++ LK +G L ++
Sbjct: 862 IKSQLKICKDEVNRLSGLQPQIERL--KIQSIALKEKGQGPMFLDADFVAFTNHFKQVFS 919
Query: 2896 QVKERENKLKESLEKA--LKYKEQVETLWPWIDKCQNNLEEIKFCLDPAE-GENSIAKLK 2952
V+ RE +L+ + ++Y+E + + W+ + + L + + E E + +L+
Sbjct: 920 DVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQ 979
Query: 2953 SLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLE 3012
+LQ + + + L+ T V E+ K+ ++ ++ + + + + L
Sbjct: 980 ALQSSLQEQQSGLYYLSTT------VKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLV 1033
Query: 3013 NMTQKFKEFQEVSKESKRQLQCAKE---QLDIH-----DSLGSQAYSNKYLTMLQTQQKS 3064
QK +E ++ + +Q K+ ++D+ +LG K L +
Sbjct: 1034 EHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSD 1093
Query: 3065 LQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKL 3124
+Q ++ ++ Q + EA + + S + +++ + + + QQV + L+ L
Sbjct: 1094 IQTIQPSLNSVNEGGQKIKNEA-EPEFASRLETELKELNTQWDHMCQQVYARKEALKGGL 1152
Query: 3125 QGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDN 3184
+ Q + EM + ++E + + LQK E +K A +
Sbjct: 1153 EKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKR---------AKEEA 1203
Query: 3185 ANKTCKMMLATEETSPDLV--------GIKRDLEALSKQCNKLLDRAQAREEQVEGTIKR 3236
K K+ L TE + + +K++LE L+ L R + + +E
Sbjct: 1204 QQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWAC 1263
Query: 3237 LEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDV 3296
E S L++ + L + E ++ + E I++ L+ + + + +
Sbjct: 1264 WHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHS----EDNPNQI 1319
Query: 3297 NWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALE 3356
L Q L + + +L+ N+RW+ L+++ +R L++++ Q A E
Sbjct: 1320 RILAQTLTDGGVMD---ELINEELETFNSRWRELHEEAVRRQKLLEQSI------QSAQE 1370
Query: 3357 SLLSWMVDTEELVANQKPPSAEF--KVVKAQI-QEQKLLQRLLDDRKSTVEVIKREGEKI 3413
+ S + E L K +A KV AQ+ QE + +Q L + ++E +K+ +
Sbjct: 1371 TEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGK 1430
Query: 3414 ATTAEPADKVKIL-KQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLT 3472
++ + K+L + ++ A R E + L+ + L
Sbjct: 1431 EAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMI--------LDEVKMHLP 1482
Query: 3473 TIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKD 3532
+E + V E + +Q L + +K+L + + + G+ + E+
Sbjct: 1483 ALETKSVEQEVVQSQ---LNHCVNLYKSLSEV----KSEVEMVIKTGRQIVQKKQTENPK 1535
Query: 3533 MVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSV 3592
+ ++ ++ Y E+ K R + L++ L ++ ++ L WL +L+K S
Sbjct: 1536 ELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSA 1595
Query: 3593 QDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKA 3652
+ L + + + Q++I +K ++ G E LK G + +++DKL + +
Sbjct: 1596 VEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVG-EALKTVLGKKETLVEDKLSLLNS 1654
Query: 3653 RYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQA 3712
+ +T + + L + + + + W+ ++ + L E++ K ++
Sbjct: 1655 NWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWI--IQADTLLDESEKKKPQQKEDV 1712
Query: 3713 QMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQ 3772
K LK E + + +DS + ++ L+ R+ +E ++E N R+ +S I
Sbjct: 1713 L---KRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRI-- 1767
Query: 3773 KVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEI 3832
K + + +QF+ +KL+ + ++Q + K +
Sbjct: 1768 KTGKASIPLKELEQFNSDI-----------QKLLEPLEAEIQQGVNLKEEDFNKDMNED- 1815
Query: 3833 LRHKDIIDDLVKSGHKIMTACSEEEK-QSMKKKLDKVLKNYDTICQINSERYLQLERAQS 3891
++ + +L++ G + ++E K + +K K + ++ + + S+R +
Sbjct: 1816 --NEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISH 1873
Query: 3892 LVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKM 3951
Q+ ++L L + + ++ LP P + R+++E+ E + +++
Sbjct: 1874 QWYQYKRQADDLLKCLDDIEKKLASLPEP-----------RDERKIKEIDRELQKKKEEL 1922
Query: 3952 NKTGPQLLELSP-GEGFSIQEKYVAADTLYSQIKE---DVKKRAVALDEAISQSTQFHDK 4007
N Q LS G +++ + + +I+ ++ A + + T
Sbjct: 1923 NAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMT 1982
Query: 4008 IDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMI 4067
D LE L + +S + ++++ ++ + D E L E+LK + +
Sbjct: 1983 EDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQ 2042
Query: 4068 ARSGGTDKDISAKA-------------VQDKLDQMVFIWENIHTLVEEREAKLLDVMELA 4114
SG D S K +Q+ L Q+ F WE ++ + ++R+ + +E
Sbjct: 2043 QSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKW 2102
Query: 4115 EKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAET---IREEIDGLQEELDI 4171
+F D + + + F+R + P + E A+ ++E DG+ + +
Sbjct: 2103 RRFHYDIKIFNQWLTEAEQFLRKTQIP--------ENWEHAKYKWYLKELQDGIGQRQTV 2154
Query: 4172 VINL---GSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQD 4228
V L G E+I + D I+++ + LN W + K DR +LEE ++Q
Sbjct: 2155 VRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQR 2214
Query: 4229 GLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELL 4288
L W++ A +AS+ + +K+++E++K E +Q +++LN +
Sbjct: 2215 DLNEFVLWLEEADN-IASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPV 2273
Query: 4289 LKKVT---EESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDEL-- 4343
L EE DK +++ L + L W + + +Q ++E + LGQ + L++L
Sbjct: 2274 LVSAPISPEEQDK--LENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEE 2331
Query: 4344 -----LAWLTHTEGLLS--EQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGN 4396
L WL+ L Q G E E+A V A Q VE + G
Sbjct: 2332 QLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIA--------VQAKQPDVEEILSKGQ 2383
Query: 4397 DLIESSAGEEASNLQNKLEVLNQRWQNV-------------------------------- 4424
L + + ++ KLE L+ W+ V
Sbjct: 2384 HLYKEKPATQP--VKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLV 2441
Query: 4425 -----LEKTEQRKQQLDGALR----QAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPET 4475
++T K ++ +L F+ +L WL+ ++ + + + + G E
Sbjct: 2442 TQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLED 2501
Query: 4476 AKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCP-KSAETNIDQDINNLKEKWESVE 4534
E + E + + L+ Q + + + A T I I ++ +W+ V+
Sbjct: 2502 INEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQ 2561
Query: 4535 TKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKV 4594
L R+ +L E L + ++ + ++ L QA L +D + +I E K
Sbjct: 2562 EHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQ 2621
Query: 4595 FANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLD 4654
A ++ + + + L D + + ++ + W + +R+ ER +L+
Sbjct: 2622 LAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALE 2681
Query: 4655 DARKRAKQFHEAWSKLMEWLEESEKSLD------SELEIANDPDKIKTQLAQHKEFQKSL 4708
+ + +QF K + WL E+E + + + + D +K + Q ++ Q +
Sbjct: 2682 ETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEI 2741
Query: 4709 GAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALL 4768
A VY + + + +DD + L L + KW + KS+ ++ LE +
Sbjct: 2742 EAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSD 2801
Query: 4769 FSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRT------ 4822
+ +LQ L+ WL + +L+ P+ GD V D H+AF++EL +
Sbjct: 2802 QWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMST 2861
Query: 4823 -------------SSVQALKRSARELI--EGSRDDSSWVKVQMQELSTRWETVCALSISK 4867
++ L + REL E +++ + ++ Q +E++T WE + S
Sbjct: 2862 LETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADW 2921
Query: 4868 QTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLE 4927
Q +++ L + +E L L +AE + D LID ++ ++K++
Sbjct: 2922 QRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGD------LLIDSLQDHLEKVK 2975
Query: 4928 EKRAEL 4933
R E+
Sbjct: 2976 ALRGEI 2981
Score = 308 bits (789), Expect = 1e-82
Identities = 502/2696 (18%), Positives = 1071/2696 (39%), Gaps = 346/2696 (12%)
Query: 2690 VKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKV 2749
V +YQ+ L + L ++ L + +S + + Q T + ++ + ++
Sbjct: 335 VNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGN 394
Query: 2750 AQALCEDLSALVK-EEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQM 2808
L L K E + E+ Q+ +L S + + A Q Q Q++
Sbjct: 395 ILQLGSKLIGTGKLSEDEETEVQEQMN-LLNSRWECLRVASMEKQSNLHRVLMDLQNQKL 453
Query: 2809 SRDFQAWLDTKKEEQNKS---HPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGE 2865
++ WL TK EE+ + P+ L+ L+ ++ HK + L Q + ++
Sbjct: 454 -KELNDWL-TKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLE-QEQVRVNSLTHMV 510
Query: 2866 NLLLKTQGSEK-AALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPW 2924
++ ++ G AAL+ QL + W + ++R L++ L K + E+ W
Sbjct: 511 VVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAW 570
Query: 2925 IDKCQNNLEEIKFC--LDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEID 2982
+ + ++ + +I D E +S+ KL L+ ++++ + L + LLS +
Sbjct: 571 LSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLST--LK 628
Query: 2983 KEVVTDENKS-----------LIQKVDMVTEQLH----------SKKFCLENMTQKFKEF 3021
+ VT + ++ L+QK++ T Q+ ++ +E +T
Sbjct: 629 NKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTRE 688
Query: 3022 QEVSK-----------ESKRQLQCAKE---QLDIHDSLGSQAYSNKYLTMLQT------- 3060
Q + K + KRQ+ E +LD+ D ++ + +LQ+
Sbjct: 689 QILVKHAQEELPPPPPQKKRQITVDSEIRKRLDV-DITELHSWITRSEAVLQSPEFAIFR 747
Query: 3061 QQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQ--------VETIAQEHSTLSQQ 3112
++ + LK +V+ +R + + D+ ++ L++ ++I Q L+ +
Sbjct: 748 KEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSR 807
Query: 3113 VDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFL 3172
E C L +L + +QN I ++Q + + + + T + IK+ L
Sbjct: 808 WIEFCQLLSERLNWL-EYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQL 866
Query: 3173 K----KLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREE 3228
K ++ L + +A +E + + D A + ++ QARE+
Sbjct: 867 KICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREK 926
Query: 3229 QVEGTIKRLE--EFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEI 3286
+++ L + + +Q++E + E + Q+L + Q
Sbjct: 927 ELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSS-- 984
Query: 3287 EPLQGKQQDVNWLGQGLIQSAAKSTS--TQGLEHDLDDVNARWKTLNKKVAQRAAQLQEA 3344
LQ +Q + +L + + + K+ S ++ + + +++ RWK L+ ++ + +L+E
Sbjct: 985 --LQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQ 1042
Query: 3345 LLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVE 3404
+ + Q+ +++L WM + + + + P + +++K Q+++ +LL + + ++
Sbjct: 1043 MNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLN 1102
Query: 3405 VIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETL 3464
+ G+KI AEP ++ +L L+++W+ + + R L+G + L
Sbjct: 1103 SVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDL 1162
Query: 3465 EPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKV 3524
++EW+T E+ + + +L++ + + K +++ + S+
Sbjct: 1163 SEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIA 1222
Query: 3525 LSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQA-LCNAKIFGEDEVELMNWLNEV 3583
+ ++ ++ +L+ Y + + + + + L++ C ++ E + WLNEV
Sbjct: 1223 QAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLE-KANKWLNEV 1281
Query: 3584 HDKLSKLSVQDYSTEGLWKQQSEL-RVLQEDILLRKQNVDQALLNGLELLKQTTGDEVL- 3641
KL +TE + E+ VL L + + D N + +L QT D +
Sbjct: 1282 EFKLK-------TTENIPGGAEEISEVLDSLENLMRHSEDNP--NQIRILAQTLTDGGVM 1332
Query: 3642 --IIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLH-STH--EELCTWLDK----- 3691
+I ++LE +R++++ + + K LEQ++Q A+ S H +E T++DK
Sbjct: 1333 DELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAY 1392
Query: 3692 ----------------VEVELLSYETQVLK------GEEASQAQM--------------- 3714
++ +L S+E + + G+EA+Q +
Sbjct: 1393 IADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSM 1452
Query: 3715 ------RPKELKKEAKNNKALLD-------------------------------SLNEVS 3737
+P ++ + +K +LD SL+EV
Sbjct: 1453 KFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVK 1512
Query: 3738 SALLELVPWRAREGLEKMVAED----NER-------YRLVSDTITQKVEEIDAAILRSQQ 3786
S + E+V R+ ++K E+ +ER Y + +T++ ++++ + S++
Sbjct: 1513 SEV-EMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRK 1571
Query: 3787 FDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSG 3846
+ + W+ T+ +L + +++ K EI + K + + + G
Sbjct: 1572 MRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVG 1631
Query: 3847 HKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPW 3906
+ T ++E ++ KL + N+ + E L Q + F + + + W
Sbjct: 1632 EALKTVLGKKETL-VEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKW 1690
Query: 3907 LTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEG 3966
+ + +++ E E + QQ+E L+ L AE K++ T Q L G
Sbjct: 1691 IIQADTLLD-------ESEKKKPQQKED-VLKRLKAELNDIRPKVDSTRDQAANLMANRG 1742
Query: 3967 FS----IQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERL 4022
++ + + ++ I +K ++ + + QF+ I ++LE LE +++
Sbjct: 1743 DHCRKLVEPQISELNHRFAAISHRIKTGKASIP--LKELEQFNSDIQKLLEPLEAEIQQ- 1799
Query: 4023 RQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAV 4082
++ + E + ++E+ +V + L QRG+ + R K K
Sbjct: 1800 ----GVNLKEEDFNKDMNEDNEGTV---------KELLQRGDNLQQRITDERKREEIKIK 1846
Query: 4083 QDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPG 4142
Q L + L +R K L++ ++ L+ + D + + L +P
Sbjct: 1847 QQLLQTK---HNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPR 1903
Query: 4143 IDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAW 4202
D +K+ + +EE++ ++ + + L + A EP + + K E+ S +
Sbjct: 1904 -DERKIKEIDRELQKKKEELNAVRRQAE---GLSEDGAAMAVEPTQIQLSKRWREIESKF 1959
Query: 4203 DSLNKAWKDRIDKL-EEAMQAAVQ------------YQDGLQAVFDWVDIAGGKLASMSP 4249
+ +I + EE M + Y + V + L +
Sbjct: 1960 AQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDL 2019
Query: 4250 IGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELK 4309
D E + +Q E LK K Q ++ ++ + L+ T ++ +Q+ L +L
Sbjct: 2020 CAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPV-ERVKLQEALSQLD 2078
Query: 4310 LIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSE-QKPVGGDPKAIE 4368
W+ + + +RQ + + ++ +F + + WLT E L + Q P + +
Sbjct: 2079 FQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYK 2138
Query: 4369 IELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKT 4428
L + LQ+ + Q+ V +N G ++I+ S+ +AS LQ KL LN RWQ V ++
Sbjct: 2139 WYLKE---LQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQL 2195
Query: 4429 EQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLG-GLPETAKEQLNVHMEVC 4487
RK++L+ F ++ + WL + + +AS PL G + KE+L +
Sbjct: 2196 SDRKKRLEEQKNILSEFQRDLNEFVLWLEEADN--IASIPLEPGKEQQLKEKLEQVKLLV 2253
Query: 4488 AAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKE---KWESVETKLNERKTKL 4544
++ K L + G +L P S E D+ N LK+ +W V L E++ ++
Sbjct: 2254 EELPLRQGILKQLNETGGPVLVSAPISPEEQ-DKLENKLKQTNLQWIKVSRALPEKQGEI 2312
Query: 4545 EEALNLAMEFHNSLQDF-------INWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFAN 4597
E + + L+D + WL+ L + ++P+ F + E ++
Sbjct: 2313 EAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPN---QEGPFDVQETEI--- 2366
Query: 4598 EVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGR------ 4651
V + + + E+ G HL + +K +K L + S W K V RL++ R
Sbjct: 2367 AVQAKQPDVEEILSKGQHL--YKEKPATQPVKRKLEDLSSEW-KAVNRLLQELRAKQPDL 2423
Query: 4652 ------------------------------------SLDDARKRAKQFHEAWSKLMEWLE 4675
SL F+ AW++L +WL
Sbjct: 2424 APGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLS 2483
Query: 4676 ESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDN 4735
++ + S+ + D + I + + K + L + + ++LK KTS +
Sbjct: 2484 LLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEAR 2543
Query: 4736 LKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQ 4795
+ D + ++++WD + R+ +L E L S Q+ +A + L + +L +
Sbjct: 2544 TIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWK 2603
Query: 4796 PVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEG-SRDDSSWVKVQMQELS 4854
+D + I K K+L + ++V A +L+ S DD+ V + + ++
Sbjct: 2604 EGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENIN 2663
Query: 4855 TRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRT 4914
W ++ ++ LE R ++F + L WL EAE T VL D R
Sbjct: 2664 ASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTAN---VLQDATRKERL 2720
Query: 4915 LIDQH--KEFMKKLEEKRAELNKATTMGDTV--------LAICHPDSITTIKHWITIIRA 4964
L D KE MK+ ++ + E+ T + + ++ D ++ + +
Sbjct: 2721 LEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNF 2780
Query: 4965 RFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVK 5024
++ E+ + + L ++ L+ LL WLQ + L+ + I + V+
Sbjct: 2781 KWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAP--IGGDFPAVQ 2838
Query: 5025 ALIAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLY 5084
H+ F E+ K+P + +T + I + ++ G ++ LY
Sbjct: 2839 KQNDVHRAFKRELKTKEPVIMSTLETVR------------IFLTEQPLEGLEK-----LY 2881
Query: 5085 PSGSQTQIETKNPRVNLLVSK--------WQQVWLLALERRRKLNDALDRLEELRE 5132
+ E + V L+ K W+++ L + + +RK+++ L+RL+EL+E
Sbjct: 2882 QEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQE 2937
Score = 295 bits (755), Expect = 9e-79
Identities = 474/2585 (18%), Positives = 1053/2585 (40%), Gaps = 294/2585 (11%)
Query: 2574 LEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRK 2633
L ES NL ++QT ++ WL+ E + G +S D ++ Q + + + +
Sbjct: 330 LMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQ 389
Query: 2634 PQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKST 2693
+ + G ++ V+EQ+ + +W+ L ++ + + ++
Sbjct: 390 GRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQ 449
Query: 2694 QYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDA--MNQQLETAQKMKQEIQQEKKQIK--V 2749
+ L+ L+D L+ + + PD + +Q++ + ++++++QE+ ++
Sbjct: 450 NQK--LKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLT 507
Query: 2750 AQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMS 2809
+ D S+ ++ A L QL+ + + ++ + E+ LQ + +
Sbjct: 508 HMVVVVDESS---GDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQ 564
Query: 2810 RDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLL 2869
F AWL K++ NK H KD + +L
Sbjct: 565 CLFSAWLSEKEDAVNKIHTTG---------FKDQNEMLSSL------------------- 596
Query: 2870 KTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWID--- 2926
+ A L+ L KQ + LK+ L LK K + W+D
Sbjct: 597 ----QKLAVLKADLEK--------KKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFA 644
Query: 2927 KCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVV 2986
+C +NL + L+ + + S A + + Q + Q M + T + V +E+
Sbjct: 645 RCWDNLVQ---KLEKSTAQISQA-VTTTQPSLTQTTVMETVTTVTTREQILVKHAQEELP 700
Query: 2987 TDE---------NKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKE 3037
+ + +++D+ +LHS E + Q EF KE KE
Sbjct: 701 PPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQS-PEFAIFRKEG--NFSDLKE 757
Query: 3038 QLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLL 3097
+++ + ++ + LQ +S QAL VE ++G +
Sbjct: 758 KVNAIEREKAEKFRK-----LQDASRSAQAL---------------VEQMVNEG-----V 792
Query: 3098 QVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRD 3157
++I Q L+ + E C L +L + +QN I ++Q + + + +
Sbjct: 793 NADSIKQASEQLNSRWIEFCQLLSERLNWL-EYQNNIIAFYNQLQQLEQMTTTAENWLKI 851
Query: 3158 AETLQKQKETIKAFLK----KLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALS 3213
T + IK+ LK ++ L + +A +E + + D A +
Sbjct: 852 QPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFT 911
Query: 3214 KQCNKLLDRAQAREEQVEGTIKRLE--EFYSKLKEFSILLQKAEEHEESQGPVGMETETI 3271
++ QARE++++ L + + +Q++E + E +
Sbjct: 912 NHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIM 971
Query: 3272 NQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTS--TQGLEHDLDDVNARWKT 3329
Q+L + Q LQ +Q + +L + + + K+ S ++ + + +++ RWK
Sbjct: 972 EQRLGELQALQSS----LQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKK 1027
Query: 3330 LNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQ 3389
L+ ++ + +L+E + + Q+ +++L WM + + + + P + +++K Q+++
Sbjct: 1028 LSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQC 1087
Query: 3390 KLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQ 3449
+LL + + ++ + G+KI AEP ++ +L L+++W+ + + R
Sbjct: 1088 RLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEA 1147
Query: 3450 LEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHN 3509
L+G + L ++EW+T E+ + + +L++ + + K +++
Sbjct: 1148 LKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKE 1207
Query: 3510 KHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQA-LCNAKI 3568
+ S+ + ++ ++ +L+ Y + + + + + L++ C ++
Sbjct: 1208 AKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHEL 1267
Query: 3569 FGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSEL-RVLQEDILLRKQNVDQALLN 3627
E + WLNEV KL +TE + E+ VL L + + D N
Sbjct: 1268 LSYLE-KANKWLNEVEFKLK-------TTENIPGGAEEISEVLDSLENLMRHSEDNP--N 1317
Query: 3628 GLELLKQTTGDEVL---IIQDKLEAIKARYKDITKLSTDVAKTLEQALQLA----RRLHS 3680
+ +L QT D + +I ++LE +R++++ + + K LEQ++Q A + LH
Sbjct: 1318 QIRILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHL 1377
Query: 3681 THEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSAL 3740
E L T++DK +L +Y + +A+Q ++++ + +++ L+ + + +
Sbjct: 1378 IQESL-TFIDK---QLAAY---IADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHN--- 1427
Query: 3741 LELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQ---FDQAADAELSW 3797
+ +E ++++++ D +K++++ Q+ F+Q
Sbjct: 1428 ------QGKEAAQRVLSQ--------IDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMI 1473
Query: 3798 ITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEE 3857
+ E + L +L +EQ+ +QL + K ++ ++K+G +I+ E
Sbjct: 1474 LDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTEN 1533
Query: 3858 KQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQL 3917
+ + +++ + +Y+ + +ER QLE+ L + + L WL T +++
Sbjct: 1534 PKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKR 1593
Query: 3918 PAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAAD 3977
A L + + ++ I + K H+ + + G L + + +++K
Sbjct: 1594 SAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKL---- 1649
Query: 3978 TLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKE 4037
+L + V RA +E ++ ++ ++ ++++ I + + Q ++ E EK K
Sbjct: 1650 SLLNSNWIAVTSRA---EEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKP 1706
Query: 4038 QISEN--KNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWEN 4095
Q E+ K + ++ ++P ++ + + ++A G D K V+ ++ ++ +
Sbjct: 1707 QQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRG----DHCRKLVEPQISELNHRFAA 1762
Query: 4096 IHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAA 4155
I ++ +A + ++ E+F D L+ ++ +L++ + + + +
Sbjct: 1763 ISHRIKTGKASI--PLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTV 1820
Query: 4156 ETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDK 4215
+ + + D LQ+ + E + +K L + ++L R K
Sbjct: 1821 KELLQRGDNLQQRI-------------TDERKREEIKIKQQLLQTKHNALKDLRSQRRKK 1867
Query: 4216 LEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQ 4275
E QY+ + +D KLAS+ P D +K+ EL++ K
Sbjct: 1868 ALEISHQWYQYKRQADDLLKCLDDIEKKLASL-PEPRDERKIKEIDRELQKKKE------ 1920
Query: 4276 IEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIIN-------RQHKL-E 4327
E+ + QAE L +E+ V+ ++L W +E + + H + E
Sbjct: 1921 -ELNAVRRQAEGL----SEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVRE 1975
Query: 4328 GALLALG-----QFQHALDELLAWLTHTEGLLSEQKPVGGDP----KAIEIELAKHHVLQ 4378
++ + + + L +TH L E + + P K E + L+
Sbjct: 1976 ETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLK 2035
Query: 4379 N--DVLAHQS-TVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQL 4435
N D L S ++ ++ ++S+ E LQ L L+ +W+ V + + R+ +
Sbjct: 2036 NIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRF 2095
Query: 4436 DGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPET---AKEQLNVHMEVCAAFEA 4492
D ++ + + FH +I+ QWLT+ E+ L ++ +PE AK + + E+
Sbjct: 2096 DRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQ----IPENWEHAKYKWYL-KELQDGIGQ 2150
Query: 4493 KEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAM 4552
++ ++L G++++ + K+ + + + + +L +W+ V +L++RK +LEE N+
Sbjct: 2151 RQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILS 2210
Query: 4553 EFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKT 4612
EF L +F+ WL +A+ ++ P + ++++ K+ E+ + + +L++T
Sbjct: 2211 EFQRDLNEFVLWLEEADNIASIPLEPGK-EQQLKEKLEQVKLLVEELPLRQGILKQLNET 2269
Query: 4613 G----THLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERG-------RSLDDARKRAK 4661
G ++QD ++N L +W KV + L E+ + L K+ +
Sbjct: 2270 GGPVLVSAPISPEEQD--KLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLE 2327
Query: 4662 QFHEAWSKLMEWLEESEKSLDSELEIANDP------DKIKTQL---AQHKEFQKSLGAKH 4712
E + L+ WL + ++LEI N P D +T++ A+ + ++ L
Sbjct: 2328 DLEEQLNHLLLWL----SPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQ 2383
Query: 4713 SVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWD------TICGKS---------- 4756
+Y T ++ L+ + ++ +L ELR K T G S
Sbjct: 2384 HLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQ 2443
Query: 4757 -----------VERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVM 4805
+E + L + F A L DWL ++ + + + GD++ +
Sbjct: 2444 PVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDIN 2503
Query: 4806 NLIDNHKAFQKELGKRTSSVQALKRSARELIE--GSRDDSSWVKVQMQELSTRWETVCAL 4863
+I KA ++L +R ++ L +A+ L +++ + + +++ + +W+ V
Sbjct: 2504 EMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEH 2563
Query: 4864 SISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFM 4923
+++ +L L+ + ++ + L +A L P DA++ I + K+
Sbjct: 2564 LQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLA 2623
Query: 4924 KKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASA 4983
K L + + ++ A + +L D + H IT E + A + +R++
Sbjct: 2624 KDLRQWQTNVDVANDLALKLLRDYSADDTRKV-HMIT------ENINASWRSIHKRVSER 2676
Query: 4984 LAGLIAKQEL-------LEALLAWLQWAETT---LTDKD-KEVIPQEIEEVKALIAEHQT 5032
A L L LE LAWL AETT L D KE + ++ + VK L+ + Q
Sbjct: 2677 EAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQD 2736
Query: 5033 FMEEM 5037
E+
Sbjct: 2737 LQGEI 2741
Score = 277 bits (708), Expect = 2e-73
Identities = 491/2725 (18%), Positives = 1089/2725 (39%), Gaps = 258/2725 (9%)
Query: 2117 QDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVK 2176
Q L+E+L W+ + E +L+ QG++ + ++D + D+ Q + + +
Sbjct: 341 QTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNILQLGS 400
Query: 2177 KFMETTDPST--ASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQT 2234
K + T S + +Q +M L++R+ E + + + ++L ++L
Sbjct: 401 KLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLH--RVLMDLQNQKLKELND 458
Query: 2235 FLETKTQALT---EVDVPGKDVTELSQYMQESTSEFLEHK---KHLEVLHSLLKEISSHG 2288
+L TKT+ T E + G D+ +L + +Q+ HK + LE + ++
Sbjct: 459 WL-TKTEERTRKMEEEPLGPDLEDLKRQVQQ-------HKVLQEDLEQEQVRVNSLTHMV 510
Query: 2289 LPSDKALVLEKTNNLSKKFKEMEDT----IKEKKEAVTSCQEQLDAFQVLVKS---LKSW 2341
+ D++ T L ++ K + D + ++ Q+ L +Q L + +W
Sbjct: 511 VVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAW 570
Query: 2342 IKETTKKVPIVQPSFGAEDLGKSLEDTKKLQ--------------EKWSLKTPEIQKVNN 2387
+ E V + + G +D + L +KL + +SLK + + N
Sbjct: 571 LSEKEDAVNKIHTT-GFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKN 629
Query: 2388 SGIS------LCNLI----SAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSI 2437
++ L N + V K+ A + AV + + T T +T+
Sbjct: 630 KSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQ--AVTTTQPSLTQTTVMETVTTVTT- 686
Query: 2438 KKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTP 2497
++ + H E+L K ++ ++ + + + W+ + Q+P
Sbjct: 687 -REQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVL----QSP 741
Query: 2498 --APTDTEAVKTQVEQN-KSFEAELKQNVNKVQELKDKLTELLEENPDTP-EAPRWKQML 2553
A E + +++ + E E + K+Q+ L+E+ + A KQ
Sbjct: 742 EFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQAS 801
Query: 2554 TEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPN 2613
+++S+W E QL +R LE NN+ F QL+Q E + + +P
Sbjct: 802 EQLNSRWIEFCQLLSERLNWLEYQ-NNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPT 860
Query: 2614 MLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDS 2673
+ +Q + + + + +PQ E+L L G+ P + A T +
Sbjct: 861 AIKSQLKICKDEVNRLSGLQPQIERLKIQSIA-LKEKGQGPMF---LDADFVAFTNHFKQ 916
Query: 2674 LTGQLSDRCDWIDQAI--VKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLE 2731
+ + R + + +YQ + ++ + + KLS T + M Q+L
Sbjct: 917 VFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLG 976
Query: 2732 TAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENH 2791
Q ++ +Q+++ + +++S E + + + E I +K + + H
Sbjct: 977 ELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSE-ISRKYQSEFEEIEGRWKKLSSQLVEH 1035
Query: 2792 VQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLT 2851
Q L+ + Q + + W+ + P ++L+ +K + +
Sbjct: 1036 CQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQ 1095
Query: 2852 AQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKA 2911
G+ + + + + L+ +L + T WD +QV R+ LK LEK
Sbjct: 1096 TIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKT 1155
Query: 2912 LKYKEQVETLWPWIDKCQNNLEEIKF-CLDPAEGENSIAKLKSLQKEMDQHFGMVELLNN 2970
+ ++ + + W+ + + E F P E + ++ ++K ++E Q V+LL
Sbjct: 1156 VSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTE 1215
Query: 2971 TANSLLSVCE-IDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESK 3029
+ NS+++ + +E + E ++L + +L+ K LE + + E +++
Sbjct: 1216 SVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKAN 1275
Query: 3030 RQLQCAKEQLDIHDSL-GSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASD 3088
+ L + +L +++ G ++ L L+ + + +Q+ + LAQ L
Sbjct: 1276 KWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRI---LAQTLT----- 1327
Query: 3089 SKGTSDVLL--QVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDD 3146
G D L+ ++ET L ++ + LE +Q + ++ + D
Sbjct: 1328 DGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDK 1387
Query: 3147 ELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIK 3206
+L + DA + ++ + I++ L E ++ EE G +
Sbjct: 1388 QLAAYIADKVDAAQMPQEAQKIQSDLTSHE----------------ISLEEMKKHNQGKE 1431
Query: 3207 RDLEALSKQCNKLLDRAQAREEQVEGTIKRLEE---FYSKLKEFSILLQKAEEHEESQGP 3263
LS+ +D AQ + + V + ++ F +L+E ++L + + H +
Sbjct: 1432 AAQRVLSQ-----IDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALET 1486
Query: 3264 VGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDV 3323
+E E + QLN K + ++ + + V G+ ++Q ++ + + L+ + +
Sbjct: 1487 KSVEQEVVQSQLNHCVNLYKS-LSEVKSEVEMVIKTGRQIVQKK-QTENPKELDERVTAL 1544
Query: 3324 NARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVK 3383
+ L KV +R QL++ L + + + L W+ T+ + + +
Sbjct: 1545 KLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLD 1604
Query: 3384 AQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKA 3443
+++ K Q+ ++ +K ++ I GE + T + + + +LSLL+S W A+ ++A
Sbjct: 1605 SEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETL-VEDKLSLLNSNWIAVTSRA 1663
Query: 3444 ETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALED 3503
E L + F + ++ + +W+ + L E Q E+ + + KA +
Sbjct: 1664 EEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQK--EDVLKRLKAELN 1721
Query: 3504 DIINHNKHLHQAVSIGQSLKVLSSRED--KDMVQSKLD-----FSQVWY-IEIQEKSHSR 3555
DI Q+ ++++R D + +V+ ++ F+ + + I+ + S
Sbjct: 1722 DIRPKVDSTRD-----QAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPL 1776
Query: 3556 SELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQ------QSELRV 3609
EL Q K+ E E+ +N + +K +D EG K+ + R+
Sbjct: 1777 KELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNED--NEGTVKELLQRGDNLQQRI 1834
Query: 3610 LQE---DILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAK 3666
E + + KQ + Q N L+ L+ + L I + K + D+ K D+ K
Sbjct: 1835 TDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEK 1894
Query: 3667 TLEQALQLA--RRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQA-QMRPKELKKEA 3723
L + R++ EL K E+ + + + L + A+ A + +L K
Sbjct: 1895 KLASLPEPRDERKIKEIDRELQK--KKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRW 1952
Query: 3724 KNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNE-RYRLVSDTITQKVEEIDAAIL 3782
+ ++ ++ A + V RE ++ ED V T ++ + A+L
Sbjct: 1953 REIESKFAQFRRLNFAQIHTV----REETMMVMTEDMPLEISYVPSTYLTEITHVSQALL 2008
Query: 3783 RSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDL 3842
+Q A D + K+ SL +I+ Q+S ++ + + L+ ++ +
Sbjct: 2009 EVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERV 2068
Query: 3843 VKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEE 3902
K+ A S+ + Q +K++K+ K+ + E++ + + NQ
Sbjct: 2069 -----KLQEALSQLDFQW--EKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQ------- 2114
Query: 3903 LWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELS 3962
WLTE + + + P E + + ++L++ I + + + +N TG ++++ S
Sbjct: 2115 ---WLTEAEQFLRKTQIP--ENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQS 2169
Query: 3963 PGEGFSI-QEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVER 4021
SI QEK + + + ++ + + R L+E + ++F +++ + LE +
Sbjct: 2170 SKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEE-ADN 2228
Query: 4022 LRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKA 4081
+ P + +++KE++ + K + ++ Q + + L + G ++ + + ++
Sbjct: 2229 IASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEE--QDK 2286
Query: 4082 VQDKLDQMVFIWENIHTLVEER----EAKLLDVMELAEKF-----WCDHMSLIVTIKDTQ 4132
+++KL Q W + + E+ EA++ D+ +L +K +H L++ + +
Sbjct: 2287 LENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNH--LLLWLSPIR 2344
Query: 4133 DFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVK 4192
+ + P + Q+ E A + Q +++ +++ G L +P VK
Sbjct: 2345 NQLEIYNQPNQEGPFDVQETEIA------VQAKQPDVEEILSKGQHLYKE--KPATQPVK 2396
Query: 4193 KSIDELNSAWDSLNKAWKD-----------------------------------RIDKLE 4217
+ +++L+S W ++N+ ++ I KLE
Sbjct: 2397 RKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLE 2456
Query: 4218 EA------MQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEA 4271
+ A + + DW+ + + S + DLE + + I + K +
Sbjct: 2457 MPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDL 2516
Query: 4272 YQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALL 4331
Q++ ++E L A+ L K + + + + D + ++ WD ++E + NR+ +L L
Sbjct: 2517 EQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLK 2576
Query: 4332 ALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAV 4391
Q+ A +E L L K AI+ ++ + L D+ Q+ V+
Sbjct: 2577 DSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVA 2636
Query: 4392 NKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIED 4451
N L+ + ++ + E +N W+++ ++ +R+ L+ R + F ++E
Sbjct: 2637 NDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEK 2696
Query: 4452 LQQWLTDTE------RHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQ 4505
WLT+ E + + L + KE + ++ EA + Y +L + Q
Sbjct: 2697 FLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQ 2756
Query: 4506 QMLARCPKSAE-TNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINW 4564
++L S + + + ++N+ KW + K ++ LE + + H SLQ+ + W
Sbjct: 2757 KILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVW 2816
Query: 4565 LTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQD 4624
L + L+ + V Q D H+ F E+ + I+ +T ++ F +Q
Sbjct: 2817 LQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLET---VRIFLTEQP 2873
Query: 4625 VVLIKNLL-----ISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKL----MEWLE 4675
+ ++ L + + R + V + L RK+A++ + W KL +W
Sbjct: 2874 LEGLEKLYQEPRELPPEERAQNVTRLL----------RKQAEEVNTEWEKLNLHSADWQR 2923
Query: 4676 ESEKSLDSELEIANDPDKIKTQLAQ 4700
+ +++L+ E+ D++ +L Q
Sbjct: 2924 KIDETLERLQELQEATDELDLKLRQ 2948
Score = 226 bits (576), Expect = 5e-58
Identities = 345/1758 (19%), Positives = 713/1758 (40%), Gaps = 172/1758 (9%)
Query: 3339 AQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDD 3398
+ L E+ ++ R+Q ALE +LSW++ E+ + Q S + +VVK Q + L
Sbjct: 328 SSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTA 387
Query: 3399 RKSTVEVIKREGEKIATTAEPA--DKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVV 3456
+ V I + G K+ T + + ++ ++ +Q++LL+SRWE L + + L + +
Sbjct: 388 HQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMD 447
Query: 3457 AQQFHETLEPLNEWLTTIEKRL--VNCEPIGTQASKLEEQIAQHKALEDDI----INHNK 3510
Q ++ L+ LN+WLT E+R + EP+G L+ Q+ QHK L++D+ + N
Sbjct: 448 LQ--NQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNS 505
Query: 3511 HLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFG 3570
H V + +S S ++ +L + I + R LLQ L +
Sbjct: 506 LTHMVVVVDES----SGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLT 561
Query: 3571 EDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLE 3630
E++ WL+E D ++K+ T G Q L LQ+ +L+ LE
Sbjct: 562 EEQCLFSAWLSEKEDAVNKI-----HTTGFKDQNEMLSSLQKLAVLKAD---------LE 607
Query: 3631 LLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLD 3690
KQ+ G + QD L +K + S ++ WLD
Sbjct: 608 KKKQSMGKLYSLKQDLLSTLKNK--------------------------SVTQKTEAWLD 641
Query: 3691 KVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRARE 3750
++ V K E+++ + + + +++++ V++ LV A+E
Sbjct: 642 NF---ARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTREQILVK-HAQE 697
Query: 3751 GLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGD 3810
L ++ ++ D+ +K ++D L SWIT +E L S
Sbjct: 698 ELPP--PPPQKKRQITVDSEIRKRLDVDITELH------------SWITRSEAVLQSPEF 743
Query: 3811 IRLEQDQTSAQLQVQKTFTMEILRHKDI--IDDLVKSGHKIMTACSEE--EKQSMKKKLD 3866
++ + L+ +K +E + + + D +S ++ E S+K+ +
Sbjct: 744 AIFRKEGNFSDLK-EKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASE 802
Query: 3867 KVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYET 3926
++ + CQ+ SER LE +++ F+ ++L T ++ + P E
Sbjct: 803 QLNSRWIEFCQLLSERLNWLEYQNNII-AFYNQLQQLEQMTTTAENWLKIQPTTPSEPTA 861
Query: 3927 LRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKED 3986
++ Q + + ++ +P I+++ L E G F + +VA + Q+ D
Sbjct: 862 IKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMF-LDADFVAFTNHFKQVFSD 920
Query: 3987 VKKRAVALDEAIS--QSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKN 4044
V+ R L ++ + + I +++ +L P + E +++++ E +
Sbjct: 921 VQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQA 980
Query: 4045 VSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEERE 4104
+ +++ Q L +EM S +IS K Q + +++ W+ + + + E
Sbjct: 981 LQSSLQEQQSGLYYLSTTVKEM---SKKAPSEISRK-YQSEFEEIEGRWKKLSSQLVEHC 1036
Query: 4105 AKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGI-DPSVVKQQQEAAETIREEID 4163
KL + M K +L + + F+++ E P + D ++K+Q + + +I
Sbjct: 1037 QKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKE-EWPALGDSEILKKQLKQCRLLVSDIQ 1095
Query: 4164 GLQEELDIVINLGSELIAACGEPD-KPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQA 4222
+Q L+ V N G + I EP+ ++ + ELN+ WD + + R + L+ ++
Sbjct: 1096 TIQPSLNSV-NEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEK 1154
Query: 4223 AVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLN 4282
V Q L + +W+ A + + +++ +EE+K+ K EA Q++ +++ L
Sbjct: 1155 TVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLT 1214
Query: 4283 HQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDE 4342
++ + + + ++ L L + L R+ + LE + L++
Sbjct: 1215 ESVNSVIAQAPPVA-QEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEK 1273
Query: 4343 LLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESS 4402
WL E L + + G + I L L+N + + + L +
Sbjct: 1274 ANKWLNEVEFKLKTTENIPGGAEEISEVLDS---LENLMRHSEDNPNQIRILAQTLTDGG 1330
Query: 4403 AGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERH 4462
+E N +LE N RW+ + E+ +R++ L+ +++ A+ + +Q+ LT ++
Sbjct: 1331 VMDELIN--EELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQ 1388
Query: 4463 LLA----SKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETN 4518
L A +P+ A++ + ++ + + EE M+K Q K A
Sbjct: 1389 LAAYIADKVDAAQMPQEAQK---IQSDLTSHEISLEE-----MKKHNQ-----GKEAAQR 1435
Query: 4519 IDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRP 4578
+ I+ ++K + V K F LQ+ L + + L
Sbjct: 1436 VLSQIDVAQKKLQDVSMKF--------RLFQKPANFEQRLQESKMILDEVKMHLPALETK 1487
Query: 4579 SLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSR 4638
S+ + V Q++ ++ + ++ + KTG + Q ++ + + +++
Sbjct: 1488 SVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLH 1547
Query: 4639 WEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQL 4698
+ ++ ++ ER + L+ K +++ + + L EWL ++ L + P + +++
Sbjct: 1548 YNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEV 1607
Query: 4699 AQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVE 4758
A K QK + + + G +L KT L ++D LS L W + ++ E
Sbjct: 1608 AWGKATQKEIEKQKVHLKSITEVGEAL--KTVLGKKETLVEDKLSLLNSNWIAVTSRAEE 1665
Query: 4759 RQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKEL 4818
N L E F + + W+ + + L E + D K + EL
Sbjct: 1666 WLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEK-----KKPQQKEDVLKRLKAEL 1720
Query: 4819 GKRTSSVQALKRSARELIEGSRDD-SSWVKVQMQELSTRWETVCALSISKQTRLEAALRQ 4877
V + + A L+ D V+ Q+ EL+ R+ + K + L++
Sbjct: 1721 NDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAIS--HRIKTGKASIPLKE 1778
Query: 4878 AEEFHSVVHALLEWL-AEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKA 4936
E+F+S + LLE L AE +Q GV +ED + + + ++ +K+L ++ L +
Sbjct: 1779 LEQFNSDIQKLLEPLEAEIQQ-----GVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQR 1833
Query: 4937 TTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIA--KQELL 4994
T R E + +Q Q +AL L + +++ L
Sbjct: 1834 IT------------------------DERKREEIKIKQQLLQTKHNALKDLRSQRRKKAL 1869
Query: 4995 EALLAWLQWAETT------LTDKDKEVI----PQEIEEVKALIAEHQTFMEEMTRKQPDV 5044
E W Q+ L D +K++ P++ ++K + E Q EE+ +
Sbjct: 1870 EISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQA 1929
Query: 5045 DKVTKTYKRRAADPSSLQ 5062
+ +++ A +P+ +Q
Sbjct: 1930 EGLSEDGAAMAVEPTQIQ 1947
Score = 221 bits (564), Expect = 1e-56
Identities = 112/232 (48%), Positives = 154/232 (66%), Gaps = 5/232 (2%)
Query: 70 ADERDKVQKKTFTKWINQHLMKVRK-HVNDLYEDLRDGHNLISLLEVLSGDTLPREKGRM 128
+DER+ VQKKTFTKW+N K K H+ +L+ DL+DG L+ LLE L+G LP+EKG
Sbjct: 6 SDEREDVQKKTFTKWVNAQFSKFGKQHIENLFSDLQDGRRLLDLLEGLTGQKLPKEKGST 65
Query: 129 RFHRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDI--HVTG 186
R H L NV AL L+ V LVNI + DI DGN KLTLGLIW IILH+Q+ ++ ++
Sbjct: 66 RVHALNNVNKALRVLQNNNVDLVNIGSTDIVDGNHKLTLGLIWNIILHWQVKNVMKNIMA 125
Query: 187 ESEDMSAKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAV- 245
+ ++++ LL W +Q+T Y + NFTT W DG NA+IH +RPDL D N+V
Sbjct: 126 GLQQTNSEKILLSWVRQSTRNYPQVNVINFTTSWSDGLALNALIHSHRPDLFDWNSVVCQ 185
Query: 246 QSNLANLEHAFYVAE-KIGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAFPK 296
QS LEHAF +A ++G+ +LLDPEDVD + PD+KS++ Y++SL+ P+
Sbjct: 186 QSATQRLEHAFNIARYQLGIEKLLDPEDVDTTYPDKKSILMYITSLFQVLPQ 237
Score = 205 bits (521), Expect = 1e-51
Identities = 284/1564 (18%), Positives = 642/1564 (41%), Gaps = 148/1564 (9%)
Query: 3506 INHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCN 3565
++H H Q +++ + + K +S ++Q Y+ + + S
Sbjct: 264 LHHQMHYSQQITVSLAQGYERTSSPKPRFKSYA-YTQAAYVTTSDPTRSPFPSQHLEAPE 322
Query: 3566 AKIFG----EDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQE--------- 3612
K FG E EV L + + + LS L + + + + +++ V+++
Sbjct: 323 DKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYM 382
Query: 3613 -DILLRKQNVDQALLNGLELLK--QTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLE 3669
D+ + V L G +L+ + + DE +Q+++ + +R++ + S + L
Sbjct: 383 MDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLH 442
Query: 3670 QALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKG--EEASQAQMRPKELKKEAKNNK 3727
+ L + + +EL WL K E E + L E+ + + K L+++ + +
Sbjct: 443 RVLMDLQ--NQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQ 500
Query: 3728 ALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQF 3787
++SL + + E A LE+ + +R+ + + + +L+ Q+
Sbjct: 501 VRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRL 560
Query: 3788 DQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGH 3847
+ +W++E E V K T +++ L K
Sbjct: 561 TEEQCLFSAWLSEKEDA-------------------VNKIHTTGFKDQNEMLSSLQKLA- 600
Query: 3848 KIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWL 3907
++ A E++KQSM K LK D + + ++ Q + ++ ++ F ++ L L
Sbjct: 601 -VLKADLEKKKQSMGKLYS--LKQ-DLLSTLKNKSVTQ--KTEAWLDNFARCWDNLVQKL 654
Query: 3908 TETQSIISQLPA---PALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPG 3964
++ + ISQ P+L T+ + +++ +H +++ PQ
Sbjct: 655 EKSTAQISQAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQ--EELPPPPPQ------- 705
Query: 3965 EGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQ 4024
+++ + D+ +++KR LD I++ + + + +L+S E + R
Sbjct: 706 -----KKRQITVDS-------EIRKR---LDVDITELHSWITRSEAVLQSPEFAIFRKE- 749
Query: 4025 PPSISAEVEKIKEQISENKNVSVD-MEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQ 4083
+KE+++ + + KLQ + + E+M+ ++ ++A +++
Sbjct: 750 -----GNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMV------NEGVNADSIK 798
Query: 4084 DKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGI 4143
+Q+ W L+ ER L+ F+ L +++++
Sbjct: 799 QASEQLNSRWIEFCQLLSER-LNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPS 857
Query: 4144 DPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWD 4203
+P+ +K Q + + + GLQ +++ L + IA + P+ +D A+
Sbjct: 858 EPTAIKSQLKICKDEVNRLSGLQPQIE---RLKIQSIALKEKGQGPMF---LDADFVAFT 911
Query: 4204 SLNKAWKDRIDKLEEAMQAA------VQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETV 4257
+ K + E+ +Q ++YQ+ + A+ WV + KL+ TD E +
Sbjct: 912 NHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIM 971
Query: 4258 KQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEE 4317
+Q++ EL+ +S +QQ + L+ + + KK E + Q E++ W L
Sbjct: 972 EQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRK-YQSEFEEIEGRWKKLSS 1030
Query: 4318 RIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVL 4377
+++ KLE + L + Q+ + L W+ + L E+ P GD + ++ +L + +L
Sbjct: 1031 QLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLL 1090
Query: 4378 QNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDG 4437
+D+ Q ++ +VN+ G + + E AS L+ +L+ LN +W ++ ++ RK+ L G
Sbjct: 1091 VSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKG 1150
Query: 4438 ALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETY 4497
L + ++ ++ +W+T E L P+ ++ + + KE
Sbjct: 1151 GLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKV 1210
Query: 4498 KSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNS 4557
K L + ++A+ P A+ + +++ L ++ + T+LN + LEE E +
Sbjct: 1211 KLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSY 1270
Query: 4558 LQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLK 4617
L+ WL + E L + + +D + + QI L +T T
Sbjct: 1271 LEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTDGG 1330
Query: 4618 YFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEES 4677
+ LI L + SRW ++ + V R + L+ + + A++ ++ + E L
Sbjct: 1331 VMDE-----LINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFI 1385
Query: 4678 EKSLDSEL-------EIANDPDKIKTQLAQH----KEFQKSLGAKHSVYDTTNRTGRSLK 4726
+K L + + ++ + KI++ L H +E +K K + ++ + K
Sbjct: 1386 DKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQK 1445
Query: 4727 EKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYR 4786
KL D+ + R + K + +L+E+ + + L AL
Sbjct: 1446 ----------KLQDVSMKFR-----LFQKPANFEQRLQESKMILDEVKMHLPAL------ 1484
Query: 4787 VEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSR-DDSSW 4845
E + E + V ++ +NL K L + S V+ + ++ R++++ + ++
Sbjct: 1485 -ETKSVEQEVVQSQLNHCVNL-------YKSLSEVKSEVEMVIKTGRQIVQKKQTENPKE 1536
Query: 4846 VKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVL 4905
+ ++ L + + A ++ +LE L+ + + ++ L EWLA + L +
Sbjct: 1537 LDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAV 1596
Query: 4906 PDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRAR 4965
L + + K K++E+++ L T +G+ + + T ++ ++++ +
Sbjct: 1597 EGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKE-TLVEDKLSLLNSN 1655
Query: 4966 FEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKA 5025
+ V + A++ L + + ++ + W+ A+T L + +K+ Q+ + +K
Sbjct: 1656 WIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKR 1715
Query: 5026 LIAE 5029
L AE
Sbjct: 1716 LKAE 1719
Score = 184 bits (467), Expect = 2e-45
Identities = 494/2698 (18%), Positives = 1056/2698 (39%), Gaps = 384/2698 (14%)
Query: 1210 KLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVF 1269
KLK +N L T+ T+ EEE + D +++ + K + ++++++
Sbjct: 452 KLKELNDWLTKTEE--------RTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRV 503
Query: 1270 HALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIG 1329
++L + + DE + L+ E+ L +RW N+ ++R L+ I
Sbjct: 504 NSLTHMV----VVVDESSGDHATAALE-----EQLKVLGDRWANICRWTEDRWVLLQDI- 553
Query: 1330 KSLKYYRDTYHP--LDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSK 1387
LK+ R T W+ + E KI ++ + + L + +L +++E K+
Sbjct: 554 -LLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQS 612
Query: 1388 MDECQKYAEQYSATVKDYELQTMT------YRAMVDSQQKSPVKRRRMQSSADLIIQEFM 1441
M + + +T+K+ + T + D+ + K S A Q +
Sbjct: 613 MGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSL 672
Query: 1442 DLRTRYTALVTLMTQ---YIKFAGDSLKRLEEEEK---SLEEEKKEHVE-KAKELQKWVS 1494
T + T+ T+ +K A + L ++K +++ E ++ ++ EL W++
Sbjct: 673 TQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWIT 732
Query: 1495 NISKTLKDAE-----KAGKPPFSKQKISS--EEISTKKEQLSEALQTIQLFLAKHGD--- 1544
L+ E K G K+K+++ E + K +L +A ++ Q + + +
Sbjct: 733 RSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGV 792
Query: 1545 -----KMTDEERNE--------LEKQVKTLQESYNLL-FSESLKQLQESQTSGD--VKV- 1587
K E+ N L +++ L+ N++ F L+QL++ T+ + +K+
Sbjct: 793 NADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQ 852
Query: 1588 -----EEKIVAERQQEYKEKLQGICDLLTQTENRLI--------GHQEAFMIGDGTVELK 1634
E + + + K+++ + L Q E I G F+ D
Sbjct: 853 PTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTN 912
Query: 1635 KY-------QSKQEELQKDM--------QGSAQALAEVVKNTENFLKENGEKLSQEDKAL 1679
+ Q++++ELQ Q + A+ V+ +E K + +LS D +
Sbjct: 913 HFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSET--KLSIPQLSVTDYEI 970
Query: 1680 IEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDW 1739
+EQ+L E ++ Q +L+ +QS ++T +KE ++K + E K ++ +
Sbjct: 971 MEQRLGE--LQALQSSLQEQQSGLYY---LSTTVKEMSKKAPS-----EISRKYQSEFEE 1020
Query: 1740 LSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQEN 1799
+ K +H Q +E+ Q + + + E DV +
Sbjct: 1021 IEGRWKKLSSQLVEHCQKLEE-----QMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALG 1075
Query: 1800 LNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYE 1859
++ +K Q ++S Q + + S +K PE +L+ +KEL ++
Sbjct: 1076 DSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWD 1135
Query: 1860 TALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKR 1919
+ + + E+ D +E W+ Q+E+E + + L ++
Sbjct: 1136 HMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEE 1195
Query: 1920 QKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRF 1979
K E+ + ++ +T S N V+ A ++ ++++L+ T +
Sbjct: 1196 MKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQ------------EALKKELETLTTNY 1243
Query: 1980 RSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQ 2039
+ L C L K L + + + + LL+ L+ A+K L+E ++ +
Sbjct: 1244 QWL---CTRLNGKCKTLEEVWACWHE----LLSYLE----KANKWLNE--------VEFK 1284
Query: 2040 LEETKALQG---QISSQQVAVEKLKKTAEVLLDARGSLLPAKND-------IQKTLDDIV 2089
L+ T+ + G +IS ++E L + +E + L D I + L+
Sbjct: 1285 LKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTDGGVMDELINEELETFN 1344
Query: 2090 GRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLK-------EQGQVPL 2142
R+ +L + R + L+ ++ + + L + + + ++ L + Q+P
Sbjct: 1345 SRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQ 1404
Query: 2143 NSTALQ-DIISKNIMLEQ---DIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLS 2198
+ +Q D+ S I LE+ G++++ +++ + D S L K +
Sbjct: 1405 EAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFE 1464
Query: 2199 ARFSEASHKHKETLAKMEELKTK--------------VELFENLSE---KLQTFLETKTQ 2241
R E+ E + L+TK V L+++LSE +++ ++T Q
Sbjct: 1465 QRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQ 1524
Query: 2242 ALTEVDVP-------------------GKDVTELSQYMQESTSEFLEHKKHLEVL----- 2277
+ + G VTE Q +++ + +K + VL
Sbjct: 1525 IVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLA 1584
Query: 2278 ---HSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVL 2334
L K + G+PS+ + K+ ++ + +K E + + L + L
Sbjct: 1585 ATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETL 1644
Query: 2335 VKSLKS-----WIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSG 2389
V+ S WI T++ AE+ L + +K E + I K
Sbjct: 1645 VEDKLSLLNSNWIAVTSR----------AEEWLNLLLEYQKHMETFDQNVDHITKWIIQA 1694
Query: 2390 ISLCNLISAVTTPAKAIAAVKSGGAVLNG-----EGTATNTEEFWANKGLTSIKKDMTDI 2444
+L + S P + +K A LN + T AN+G
Sbjct: 1695 DTLLD-ESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRG----------- 1742
Query: 2445 SHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEA 2504
+ L++ +I+ELN + + + + A + L+++ + + Q+ P + E
Sbjct: 1743 ----DHCRKLVEPQISELNHRFAAISHRIKTGKASIP-LKELEQFNSDIQKLLEPLEAEI 1797
Query: 2505 VKTQVEQNKSFEAELKQ-NVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQEL 2563
+ + + F ++ + N V+EL + L + D + K + +K L
Sbjct: 1798 QQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNAL 1857
Query: 2564 NQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQ 2623
L R++K E S+ Q++ L + L + E ++ L P D + +++Q
Sbjct: 1858 KDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASL-PEPRDERKIKEIDRELQ 1916
Query: 2624 ILLQEFATRKPQYEQLTAAGQGILSRP-------------GEDPSLRGIVKEQLAAVTQK 2670
+E + Q E L+ G + P + R + Q+ V ++
Sbjct: 1917 KKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREE 1976
Query: 2671 WDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQL 2730
T + ++ + V ST Y + + +S L +++ L++ + + + +Q
Sbjct: 1977 ----TMMVMTEDMPLEISYVPST-YLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQE 2031
Query: 2731 ETAQKMKQEIQQEKKQIKVAQALCEDLSAL--------VKEEYLKAELSRQLEGILKSFK 2782
E+ + +K +QQ +I + + + +AL VK + ++L Q E + K +K
Sbjct: 2032 ESLKNIKDSLQQSSGRIDIIHS--KKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYK 2089
Query: 2783 DVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSH-PISAKLDVLESLIK 2841
D + + + V+ + F Q + + +L + +N H L L+ I
Sbjct: 2090 DRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKELQDGIG 2149
Query: 2842 DHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERE 2901
+ +TL A GE ++ ++ ++ + LQ +L ++ W KQ+ +R+
Sbjct: 2150 QRQTVVRTLN----------ATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRK 2199
Query: 2902 NKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGE---NSIAKLKSLQKEM 2958
+L+E +++ + W+++ +N+ I L+P + + + ++K L +E+
Sbjct: 2200 KRLEEQKNILSEFQRDLNEFVLWLEEA-DNIASIP--LEPGKEQQLKEKLEQVKLLVEEL 2256
Query: 2959 DQHFGMVELLNNTANSLLSVCEIDKEVVTD-ENK-------------------------- 2991
G+++ LN T +L I E ENK
Sbjct: 2257 PLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQI 2316
Query: 2992 ----SLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKE-----SKRQLQCAKEQLDIH 3042
L +K++ + EQL+ L + + + + + ++E + ++ +Q D+
Sbjct: 2317 KDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVE 2376
Query: 3043 DSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASD---------SKGTS 3093
+ L + K Q ++ L+ L + RL Q+L + D + T
Sbjct: 2377 EILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQ 2436
Query: 3094 DVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAP 3153
V L + + + + +S+ E S L ++ + F E+ + D + S
Sbjct: 2437 TVTLVTQPVVTKETAISKL--EMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRV 2494
Query: 3154 VGRDAETLQ----KQKETIKAFLKK---LEALMASNDN-ANKTCKMMLATEETSPDLVGI 3205
+ D E + KQK T++ ++ LE L+ + N NKT T T
Sbjct: 2495 MVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITD------ 2548
Query: 3206 KRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVG 3265
+E + Q +++ + Q R +Q+ +K ++ +E +L +A ES
Sbjct: 2549 --RIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGP 2606
Query: 3266 METETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNA 3325
+ I +++ K K ++ Q N L L++ + + T+ + +++NA
Sbjct: 2607 YTVDAIQKKITETKQLAK-DLRQWQTNVDVANDLALKLLRDYS-ADDTRKVHMITENINA 2664
Query: 3326 RWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELV-----ANQKPPSAE-F 3379
W++++K+V++R A L+E +F LE L+W+ + E A +K E
Sbjct: 2665 SWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDS 2724
Query: 3380 KVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKIL-KQLSLLDSRWEA 3438
K VK +++ + LQ ++ + +KI + E +D +L ++L ++ +W
Sbjct: 2725 KGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSE 2784
Query: 3439 LLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQH 3498
L K+ LE S ++ H +L+ L WL + L PIG +++Q H
Sbjct: 2785 LRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVH 2844
Query: 3499 KALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSEL 3558
+A + ++ + +S +++++ + + + ++ + + + +E++ + + L
Sbjct: 2845 RAFKRELKTKEPVI---MSTLETVRIFLTEQPLEGLEKL--YQEPRELPPEERAQNVTRL 2899
Query: 3559 LQQALCNAKIFGED-EVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLR 3617
L++ E + +W ++ + L +L +T+ L +L++ Q +++
Sbjct: 2900 LRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDEL-----DLKLRQAEVIKG 2954
Query: 3618 K-QNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQL 3674
Q V L++ L QD LE +KA +I L +V+ + A QL
Sbjct: 2955 SWQPVGDLLIDSL--------------QDHLEKVKALRGEIAPLKENVSHVNDLARQL 2998
Score = 38.9 bits (89), Expect = 0.14
Identities = 46/168 (27%), Positives = 73/168 (43%), Gaps = 27/168 (16%)
Query: 648 VQDLLNWVDEMQVQLDR-TEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMT 706
+Q+LL W+ +L R G D P+V+ +VHRA + E KE I T
Sbjct: 2810 LQELLVWLQLKDDELSRQAPIGGDFPAVQKQ----NDVHRAFKR-ELKTKEPVIMSTLET 2864
Query: 707 APLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYD 766
+ LT + L LE Y + R L RA N + L K+ EEV +
Sbjct: 2865 VRIFLT-EQPLEGLEKLY--------QEPRELPP----EERAQN-VTRLLRKQAEEVNTE 2910
Query: 767 WSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARL 814
W + N + A+ R++D+ E ++ +QE ++L L+ A +
Sbjct: 2911 WEKLNL-------HSADWQRKIDETLERLQELQEATDELDLKLRQAEV 2951
>gi|5032285 dystrophin Dp427l isoform [Homo sapiens]
Length = 3562
Score = 325 bits (832), Expect = 1e-87
Identities = 545/2835 (19%), Positives = 1126/2835 (39%), Gaps = 316/2835 (11%)
Query: 2230 EKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHL-----------EVLH 2278
++ QT LE L + + E+S ++ +F H+ ++ +L
Sbjct: 219 DRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNILQ 278
Query: 2279 SLLKEISSHGLPSDKAL-VLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKS 2337
K I + L D+ V E+ N L+ +++ + EK+ + + +D +K
Sbjct: 279 LGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLH--RVLMDLQNQKLKE 336
Query: 2338 LKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLIS 2397
L W+ +T ++ ++ E LG LED K+ ++ + ++++ SL +++
Sbjct: 337 LNDWLTKTEERTRKMEE----EPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVV 392
Query: 2398 AVTTPA--KAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLL 2455
V + A AA++ VL WAN I ED +LL
Sbjct: 393 VVDESSGDHATAALEEQLKVLGDR---------WAN------------ICRWTEDRWVLL 431
Query: 2456 KDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSF 2515
+D L K Q+ EE WL + K T E + + +++
Sbjct: 432 QDI-------LLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSS-LQKLAVL 483
Query: 2516 EAEL---KQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEI-DSKWQELNQLTIDRQ 2571
+A+L KQ++ K+ LK L L+ T + W D+ Q+L + T
Sbjct: 484 KADLEKKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQIS 543
Query: 2572 QKLEESSNNLTQFQTVEA------------------------------------------ 2589
Q + + +LTQ +E
Sbjct: 544 QAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDV 603
Query: 2590 ---QLKQWLVEKELMV-SVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQG 2645
+L W+ E ++ S + + +++V + +E A + + + + + Q
Sbjct: 604 DITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQA 663
Query: 2646 ILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDK 2705
++ + + +K+ + +W LS+R +W++ + + L+ L
Sbjct: 664 LVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQN-NIIAFYNQLQQLEQM 722
Query: 2706 LSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEE- 2764
+ +N L + P A+ QL+ + + + QI+ + S +KE+
Sbjct: 723 TTTAENWLKIQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQ----SIALKEKG 778
Query: 2765 ----YLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKK 2820
+L A+ + F DV+ + E +Q + ++Q+ + W+ +
Sbjct: 779 QGPMFLDADFVAFTNHFKQVFSDVQAR-EKELQTIFDTLPPM-RYQETMSAIRTWVQQSE 836
Query: 2821 EEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQ 2880
+ + +++E + + + +L Q + + K Q
Sbjct: 837 TKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQ 896
Query: 2881 LQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLD 2940
+ I+ W + Q+ E KL+E + K K + ++TL W+ + L+E
Sbjct: 897 SEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEW---- 952
Query: 2941 PAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTD-----------E 2989
PA G++ I L+K++ Q +V + SL SV E +++ + E
Sbjct: 953 PALGDSEI-----LKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETE 1007
Query: 2990 NKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQA 3049
K L + D + +Q++++K L+ +K Q+ E + A+E+ D
Sbjct: 1008 LKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERD------ 1061
Query: 3050 YSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTL 3109
+ K LQ + ++ K + K L+ E+ +S + E + +E TL
Sbjct: 1062 FEYKTPDELQKAVEEMKRAKEEAQ-QKEAKVKLLTESVNSVIAQAPPVAQEALKKELETL 1120
Query: 3110 SQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIK 3169
+ C+ L K + + E+ S + + L+ + + E + E I
Sbjct: 1121 TTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEIS 1180
Query: 3170 AFLKKLEALMA-SNDNANKTCKMMLATEETSPDLVG--IKRDLEALSKQCNKLLDRAQAR 3226
L LE LM S DN N+ +LA T ++ I +LE + + +L + A R
Sbjct: 1181 EVLDSLENLMRHSEDNPNQI--RILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRR 1238
Query: 3227 EEQVEGTIKRLEEFYSKL---KEFSILLQK------AEEHEESQGPVGMETETINQQLNM 3277
++ +E +I+ +E L +E + K A++ + +Q P E + I L
Sbjct: 1239 QKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMP--QEAQKIQSDLTS 1296
Query: 3278 FKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQR 3337
++ +E + QGK+ L Q I A K L DV+ +++ L +K A
Sbjct: 1297 HEISLEEMKKHNQGKEAAQRVLSQ--IDVAQKK---------LQDVSMKFR-LFQKPANF 1344
Query: 3338 AAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLD 3397
+LQE+ + + L +L + S E +VV++Q+ L + L
Sbjct: 1345 EQRLQESKMILDEVKMHLPAL--------------ETKSVEQEVVQSQLNHCVNLYKSLS 1390
Query: 3398 DRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVA 3457
+ KS VE++ + G +I + + ++ ++++ L + L K R +QLE ++
Sbjct: 1391 EVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLS 1450
Query: 3458 QQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVS 3517
++ + + L EWL + L + S L+ ++A KA + +I HL
Sbjct: 1451 RKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITE 1510
Query: 3518 IGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELM 3577
+G++LK + +++ +V+ KL +I + ++ LL + + + F ++ +
Sbjct: 1511 VGEALKTVLGKKET-LVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHIT 1569
Query: 3578 NWLNEVHDKL--SKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQT 3635
W+ + L S+ + L + ++EL ++ + + + N + ++
Sbjct: 1570 KWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKL 1629
Query: 3636 TGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVE 3695
++ + + AI R K T ++ K LEQ ++L L+ +E E
Sbjct: 1630 VEPQISELNHRFAAISHRIK--TGKASIPLKELEQFNSDIQKL----------LEPLEAE 1677
Query: 3696 LLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKM 3755
+ + LK E+ + K++ ++ N + + L + + R RE ++
Sbjct: 1678 I--QQGVNLKEEDFN------KDMNED--NEGTVKELLQRGDNLQQRITDERKREEIKIK 1727
Query: 3756 VAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQ 3815
++ + D +Q+ ++ + Q+ + AD L + + EKKL SL + R E+
Sbjct: 1728 QQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDER 1787
Query: 3816 D--QTSAQLQVQKTFTMEILRHKDII--DDLVKSGHKIMTACSEEEKQSMKKKLDKVLKN 3871
+ +LQ +K + R + + D + S+ ++ K N
Sbjct: 1788 KIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLN 1847
Query: 3872 YDTICQINSERYLQLERAQSL-VNQFWETY----EELWPWLTETQSIISQLPAPALEYET 3926
+ I + E + + L ++ TY + L E + +++ A ++E
Sbjct: 1848 FAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFED 1907
Query: 3927 LRQQQEEHRQLRELIAEHKPHIDKMN-KTGPQLLELSPGEGFSIQEKYVAADTLYSQIKE 3985
L +Q+E + +++ + + ID ++ K L +P E +QE D + ++ +
Sbjct: 1908 LFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNK 1967
Query: 3986 DVKKRAVALDEAISQSTQFHDKI---DQILESLERIVERLRQPPSISAEVEKIKEQISEN 4042
K R D ++ + +FH I +Q L E+ + + + P + E K K + E
Sbjct: 1968 MYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENW--EHAKYKWYLKEL 2025
Query: 4043 KNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEE 4102
++ + + Q + TL GEE+I +S TD I +Q+KL + W+ + + +
Sbjct: 2026 QD---GIGQRQTVVRTLNATGEEIIQQSSKTDASI----LQEKLGSLNLRWQEVCKQLSD 2078
Query: 4103 REAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEI 4162
R+ +L + + +F D ++ +++ + +PG + + K++ E + + EE+
Sbjct: 2079 RKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQL-KEKLEQVKLLVEEL 2137
Query: 4163 DGLQEELDIVINLGSELIAACG----EPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEE 4218
Q L + G ++ + E DK ++ + + N W +++A ++ ++E
Sbjct: 2138 PLRQGILKQLNETGGPVLVSAPISPEEQDK--LENKLKQTNLQWIKVSRALPEKQGEIEA 2195
Query: 4219 AMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEE----LKQFKSEAYQQ 4274
++ Q + L+ D + L +SPI LE Q +E +++ + +
Sbjct: 2196 QIKDLGQLEKKLE---DLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAK 2252
Query: 4275 QIEMERLNHQAELLLK-KVTEESDKHTVQDPLMELKLIWDSLEER--------------- 4318
Q ++E + + + L K K + K ++D E K + L+E
Sbjct: 2253 QPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIG 2312
Query: 4319 -------------IINRQ---HKLE--GALL----ALGQFQHALDELLAWLTHTEGLLSE 4356
++ ++ KLE +L+ AL F A EL WL+ + ++
Sbjct: 2313 ASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKS 2372
Query: 4357 QKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNL-QNKLE 4415
Q+ + GD + I + K D+ + +E + A +L ++ +EA + +++E
Sbjct: 2373 QRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIE 2432
Query: 4416 VLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPET 4475
+ +W V E + R+QQL+ L+ + + E+ +Q L L + K +
Sbjct: 2433 RIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDA 2492
Query: 4476 AKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVET 4535
++++ ++ + ++L + N+ W S+
Sbjct: 2493 IQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHK 2552
Query: 4536 KLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNV---ASRPSLILDT---VLFQI 4589
+++ER+ LEE L +F L+ F+ WLT+AE T NV A+R +L+ V +
Sbjct: 2553 RVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELM 2612
Query: 4590 DEHKVFANEVNSHREQIIELDKTGTH-LKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVE 4648
+ + E+ +H + LD+ L+ D VL++ L ++ +W ++ ++ +
Sbjct: 2613 KQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLN 2672
Query: 4649 RGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSL 4708
L+ + + K+ H + +L+ WL+ + L + I D ++ Q H+ F++ L
Sbjct: 2673 IRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKREL 2732
Query: 4709 GAKHSVYDTTNRT-------------------GRSLKEKTSLADDNLKLDDMLSELRDKW 4749
K V +T T R L + + L E+ +W
Sbjct: 2733 KTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEW 2792
Query: 4750 DTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGD--IDLVMNL 4807
+ + S + Q K++E L + +A L L + E QPV GD ID + +
Sbjct: 2793 EKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPV-GDLLIDSLQDH 2851
Query: 4808 IDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISK 4867
++ KA + E+ +V + AR+L S + +++L+TRW+ +
Sbjct: 2852 LEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLL------- 2904
Query: 4868 QTRLEAALRQAEEFH 4882
Q +E +RQ E H
Sbjct: 2905 QVAVEDRVRQLHEAH 2919
Score = 316 bits (809), Expect = 5e-85
Identities = 548/2809 (19%), Positives = 1128/2809 (40%), Gaps = 353/2809 (12%)
Query: 1879 LEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYIT 1938
L+++ E WL +E L+ ++D+ + + + + D+ +H+G + I
Sbjct: 218 LDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNIL 277
Query: 1939 ISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVD 1998
G++++ K + EVQ +++ R+ L +NL ++
Sbjct: 278 QLGSKLIGTGKLSEDEE----------TEVQEQMNLLNSRWECLRVASMEKQSNLHRVLM 327
Query: 1999 KYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVE 2058
Q+ + L L E K EP+ D ++L+RQ+++ K LQ + +QV V
Sbjct: 328 DLQNQKLKE--LNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVN 385
Query: 2059 KLKKTAEVLLDARGSLLPAKNDIQ-KTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQ 2117
L V+ ++ G A + Q K L D R+ ++ + +R LQ L + +
Sbjct: 386 SLTHMVVVVDESSGDHATAALEEQLKVLGD---RWANICRWTEDRWVLLQDILLKWQRLT 442
Query: 2118 DGLDEMLDWMGNVESSLKEQGQVPLNSTALQD------IISKNIMLEQDIAGRQSSINAM 2171
+ W+ E ++ + +++T +D + K +L+ D+ ++ S+ +
Sbjct: 443 EEQCLFSAWLSEKEDAVNK-----IHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKL 497
Query: 2172 NEKVKKFMETT-DPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSE 2230
+ + T + S +A + + + + K +++ A++ + T + +L++
Sbjct: 498 YSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQ--PSLTQ 555
Query: 2231 KLQTFLETKTQALTEVDVPGKDVTEL-----SQYMQESTSEFLEHKKHLEV----LHSLL 2281
T +ET T T + K E Q ++ T + E +K L+V LHS +
Sbjct: 556 T--TVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDS-EIRKRLDVDITELHSWI 612
Query: 2282 KEISSHGLPSDKALVLEKTNNLS--------------KKFKEMEDTIKEKK--------- 2318
S L S + + K N S +KF++++D + +
Sbjct: 613 TR-SEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNE 671
Query: 2319 ----EAVTSCQEQLDA----FQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKK 2370
+++ EQL++ F L+ +W++ + E + + E+ K
Sbjct: 672 GVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLK 731
Query: 2371 LQEKWSLKTPEIQKVNNSGISLC-NLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFW 2429
+Q TP S + +C + ++ ++ I +K L +G
Sbjct: 732 IQPT----TPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKG--------- 778
Query: 2430 ANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKL--QKAQEESSAMMQWLQKMN 2487
+G + D ++ ++ + ++ + EL T L + QE SA+ W+Q+ +
Sbjct: 779 --QGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQ-S 835
Query: 2488 KTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAP 2547
+T Q TD E ++ ++ + ++ ++ L++ + + L + E+ ++ P + +
Sbjct: 836 ETKLSIPQLSV-TDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAP-SEISR 893
Query: 2548 RWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGP 2607
+++ EI+ +W++L+ ++ QKLEE N L + Q LK+W+ E ++ + P
Sbjct: 894 KYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWP 953
Query: 2608 LSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAV 2667
D +L Q +Q ++L+ + T +P + GQ I + +P ++ +L +
Sbjct: 954 ALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEA--EPEFASRLETELKEL 1011
Query: 2668 TQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMN 2727
+WD + Q+ R + + + K+ Q L + + ++ + + PD +
Sbjct: 1012 NTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQ 1071
Query: 2728 QQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAE--LSRQLEGILKSFKDVE 2785
+ +E ++ K+E QQ++ ++K+ L E +++++ + A+ L ++LE + +++ +
Sbjct: 1072 KAVEEMKRAKEEAQQKEAKVKL---LTESVNSVIAQAPPVAQEALKKELETLTTNYQWLC 1128
Query: 2786 QKAENHVQHLQSACASSHQFQQMSRDFQAWLD-------TKKEEQNKSHPISAKLDVLES 2838
+ + L+ A H+ WL+ T + + IS LD LE+
Sbjct: 1129 TRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLEN 1188
Query: 2839 LIKDHKD-------FSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQ--------- 2882
L++ +D ++TLT M E E E + + + A++ Q
Sbjct: 1189 LMRHSEDNPNQIRILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQS 1248
Query: 2883 -------LNTIKTNWDTFNKQVK-------------ERENKLKE-------SLEKALKY- 2914
L+ I+ + +KQ+ + K++ SLE+ K+
Sbjct: 1249 AQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHN 1308
Query: 2915 --KEQVETLWPWIDKCQNNLEEI--KFCL--DPAEGENSIAKLKSLQKEMDQHFGMVEL- 2967
KE + + ID Q L+++ KF L PA E + + K + E+ H +E
Sbjct: 1309 QGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETK 1368
Query: 2968 ----------LNNTANSLLSVCEIDKEV--VTDENKSLIQKVDMVTEQLHSKKFCLENMT 3015
LN+ N S+ E+ EV V + ++QK +Q + K E +T
Sbjct: 1369 SVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQK-----KQTENPKELDERVT 1423
Query: 3016 QKFKEFQEVSK---ESKRQLQ-CAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQ 3071
+ E+ E K+QL+ C K + + M T++ +++ +
Sbjct: 1424 ALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSN 1483
Query: 3072 VDL----AKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGI 3127
+D K +++ + K ++V ++T+ + TL V++K S L + +
Sbjct: 1484 LDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETL---VEDKLSLLNSNWIAV 1540
Query: 3128 G----HFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASND 3183
+ N + E FD +D + A+TL + E K K+ + L
Sbjct: 1541 TSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKE-DVLKRLKA 1599
Query: 3184 NANKTCKMMLATEETSPDLVGIKRD--LEALSKQCNKLLDRAQAREEQVEG-----TIKR 3236
N + +T + + +L+ + D + + Q ++L R A +++ +K
Sbjct: 1600 ELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKE 1659
Query: 3237 LEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDV 3296
LE+F S +++ LL+ E E Q V ++ E N+ +N E +G +++
Sbjct: 1660 LEQFNSDIQK---LLEPLEA--EIQQGVNLKEEDFNKDMN----------EDNEGTVKEL 1704
Query: 3297 NWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALE 3356
G L Q + ++ + + L +QR + E +++ +
Sbjct: 1705 LQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQAD 1764
Query: 3357 SLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKI--- 3413
LL + D E+ +A+ P E K+ K + R L +K + ++R+ E +
Sbjct: 1765 DLLKCLDDIEKKLASLPEPRDERKI--------KEIDRELQKKKEELNAVRRQAEGLSED 1816
Query: 3414 --ATTAEPADKVKILKQLSLLDSRWEAL--LNKAE------------TRNRQLEGISVVA 3457
A EP ++++ K+ ++S++ LN A+ T + LE IS V
Sbjct: 1817 GAAMAVEPT-QIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLE-ISYVP 1874
Query: 3458 QQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHL---HQ 3514
+ + +++ L +E+ L + L +Q K ++D + + + H
Sbjct: 1875 STYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHS 1934
Query: 3515 AVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEV 3574
+ R S+LDF + ++ + R +++ + F D
Sbjct: 1935 KKTAALQSATPVERVKLQEALSQLDFQ---WEKVNKMYKDRQGRFDRSVEKWRRFHYDIK 1991
Query: 3575 ELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQ 3634
WL E L K + + +K L+ LQ+ I R+ V G E+++Q
Sbjct: 1992 IFNQWLTEAEQFLRKTQIPENWEHAKYKWY--LKELQDGIGQRQTVVRTLNATGEEIIQQ 2049
Query: 3635 TTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEV 3694
++ + I+Q+KL ++ R++++ K +D K LE+ + E WL++ +
Sbjct: 2050 SSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEAD- 2108
Query: 3695 ELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREG--L 3752
+ S + K ++ + + K L +E + +L LNE +L P E L
Sbjct: 2109 NIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKL 2168
Query: 3753 EKMVAEDNERYRLVSDTITQKVEEIDAAIL-------RSQQFDQAADAELSWITETEKKL 3805
E + + N ++ VS + +K EI+A I + + ++ + L W++ +L
Sbjct: 2169 ENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQL 2228
Query: 3806 MSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKL 3865
Q VQ+T + D+ + L K H + Q +K+KL
Sbjct: 2229 EIYN-----QPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYK---EKPATQPVKRKL 2280
Query: 3866 DKVLKNYDTICQINSE-RYLQLERAQ-------------SLVNQFWETYEELWPWLTETQ 3911
+ + + + ++ E R Q + A +LV Q T E L
Sbjct: 2281 EDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPS 2340
Query: 3912 SIISQLPAPA--------------LEYETLRQQQE---EHRQLRELIAEHKPHIDKMNKT 3954
S++ ++PA A L + ++ Q+ + + E+I + K + + +
Sbjct: 2341 SLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQR 2400
Query: 3955 GPQLLEL-----------SPGEGFSI-QEKYVAADTLYSQIKEDVKKRAVALDEAISQST 4002
PQL EL S E +I ++ + +++E ++ R L+E + ST
Sbjct: 2401 RPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDST 2460
Query: 4003 QF---HDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETL 4059
Q+ ++ +Q+L +E ++ P V+ I+++I+E K ++ D+ + Q +
Sbjct: 2461 QWLEAKEEAEQVLGQARAKLESWKEGPYT---VDAIQKKITETKQLAKDLRQWQTNVDVA 2517
Query: 4060 KQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWC 4119
+++ R D + + ++ W +IH V EREA L + L ++F
Sbjct: 2518 NDLALKLL-RDYSADDTRKVHMITENINAS---WRSIHKRVSEREAALEETHRLLQQFPL 2573
Query: 4120 DHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEEL----DIVINL 4175
D + + + + L+D +++ + E +++ D LQ E+ D+ NL
Sbjct: 2574 DLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQD-LQGEIEAHTDVYHNL 2632
Query: 4176 GSE----LIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQ 4231
L + G D ++++ +D +N W L K + LE + + LQ
Sbjct: 2633 DENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQ 2692
Query: 4232 AVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAY------------------Q 4273
+ W+ + +L+ +PIG D V++Q + + FK E +
Sbjct: 2693 ELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTE 2752
Query: 4274 QQIE-MERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLA 4332
Q +E +E+L + L + ++ ++ E+ W+ L + Q K++ L
Sbjct: 2753 QPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLER 2812
Query: 4333 LGQFQHALDELLAWLTHTEGLLSEQKPVGG-DPKAIEIELAKHHVLQNDVLAHQSTVEAV 4391
L + Q A DEL L E + +PVG +++ L K L+ ++ + V V
Sbjct: 2813 LQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHV 2872
Query: 4392 NKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALR 4440
N L NL + LE LN RW+ + E R +QL A R
Sbjct: 2873 NDLARQLTTLGIQLSPYNL-STLEDLNTRWKLLQVAVEDRVRQLHEAHR 2920
Score = 313 bits (803), Expect = 2e-84
Identities = 505/2706 (18%), Positives = 1066/2706 (39%), Gaps = 308/2706 (11%)
Query: 2413 GAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKA 2472
G+ L G G + EE T +++ M ++ +E L + +K + L+ L LQ
Sbjct: 280 GSKLIGTGKLSEDEE-------TEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQN- 331
Query: 2473 QEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDK 2532
++ + WL K + K ++ P D E +K QV+Q+K + +L+Q +V L
Sbjct: 332 -QKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHM 390
Query: 2533 LTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLK 2592
+ + E + D A +Q L + +W + + T DR L++ + +
Sbjct: 391 VVVVDESSGDHATAALEEQ-LKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFS 449
Query: 2593 QWLVEKELMVSVLGPLSI-DPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPG 2651
WL EKE V+ + D N + + Q++ +L + +K +L + Q +LS
Sbjct: 450 AWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTL- 508
Query: 2652 EDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKS-----------------TQ 2694
++ S+ + L + WD+L +L I QA+ + T+
Sbjct: 509 KNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTR 568
Query: 2695 YQSLLRSLSDKLSD----------LDNKLSSSLAVS--------THPDAMNQQLETAQKM 2736
Q L++ ++L +D+++ L V T +A+ Q E A
Sbjct: 569 EQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFR 628
Query: 2737 KQ-----------EIQQEKKQ--------IKVAQALCEDL-SALVKEEYLKAELSRQLEG 2776
K+ I++EK + + AQAL E + + V + +K + S QL
Sbjct: 629 KEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIK-QASEQLNS 687
Query: 2777 ILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPIS-AKLDV 2835
F + + N +++ + A +Q QQ+ + + T E K P + ++
Sbjct: 688 RWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQ-----MTTTAENWLKIQPTTPSEPTA 742
Query: 2836 LESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNK 2895
++S +K KD L+ E+ + +++ LK +G L ++
Sbjct: 743 IKSQLKICKDEVNRLSGLQPQIERL--KIQSIALKEKGQGPMFLDADFVAFTNHFKQVFS 800
Query: 2896 QVKERENKLKESLEKA--LKYKEQVETLWPWIDKCQNNLEEIKFCLDPAE-GENSIAKLK 2952
V+ RE +L+ + ++Y+E + + W+ + + L + + E E + +L+
Sbjct: 801 DVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQ 860
Query: 2953 SLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLE 3012
+LQ + + + L+ T V E+ K+ ++ ++ + + + + L
Sbjct: 861 ALQSSLQEQQSGLYYLSTT------VKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLV 914
Query: 3013 NMTQKFKEFQEVSKESKRQLQCAKE---QLDIH-----DSLGSQAYSNKYLTMLQTQQKS 3064
QK +E ++ + +Q K+ ++D+ +LG K L +
Sbjct: 915 EHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSD 974
Query: 3065 LQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKL 3124
+Q ++ ++ Q + EA + + S + +++ + + + QQV + L+ L
Sbjct: 975 IQTIQPSLNSVNEGGQKIKNEA-EPEFASRLETELKELNTQWDHMCQQVYARKEALKGGL 1033
Query: 3125 QGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDN 3184
+ Q + EM + ++E + + LQK E +K A +
Sbjct: 1034 EKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKR---------AKEEA 1084
Query: 3185 ANKTCKMMLATEETSPDLV--------GIKRDLEALSKQCNKLLDRAQAREEQVEGTIKR 3236
K K+ L TE + + +K++LE L+ L R + + +E
Sbjct: 1085 QQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWAC 1144
Query: 3237 LEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDV 3296
E S L++ + L + E ++ + E I++ L+ + + + +
Sbjct: 1145 WHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHS----EDNPNQI 1200
Query: 3297 NWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALE 3356
L Q L + + +L+ N+RW+ L+++ +R L++++ Q A E
Sbjct: 1201 RILAQTLTDGGVMD---ELINEELETFNSRWRELHEEAVRRQKLLEQSI------QSAQE 1251
Query: 3357 SLLSWMVDTEELVANQKPPSAEF--KVVKAQI-QEQKLLQRLLDDRKSTVEVIKREGEKI 3413
+ S + E L K +A KV AQ+ QE + +Q L + ++E +K+ +
Sbjct: 1252 TEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGK 1311
Query: 3414 ATTAEPADKVKIL-KQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLT 3472
++ + K+L + ++ A R E + L+ + L
Sbjct: 1312 EAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMI--------LDEVKMHLP 1363
Query: 3473 TIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKD 3532
+E + V E + +Q L + +K+L + + + G+ + E+
Sbjct: 1364 ALETKSVEQEVVQSQ---LNHCVNLYKSLSEV----KSEVEMVIKTGRQIVQKKQTENPK 1416
Query: 3533 MVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSV 3592
+ ++ ++ Y E+ K R + L++ L ++ ++ L WL +L+K S
Sbjct: 1417 ELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSA 1476
Query: 3593 QDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKA 3652
+ L + + + Q++I +K ++ G E LK G + +++DKL + +
Sbjct: 1477 VEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVG-EALKTVLGKKETLVEDKLSLLNS 1535
Query: 3653 RYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQA 3712
+ +T + + L + + + + W+ ++ + L E++ K ++
Sbjct: 1536 NWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWI--IQADTLLDESEKKKPQQKEDV 1593
Query: 3713 QMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQ 3772
K LK E + + +DS + ++ L+ R+ +E ++E N R+ +S I
Sbjct: 1594 L---KRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRI-- 1648
Query: 3773 KVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEI 3832
K + + +QF+ +KL+ + ++Q + K +
Sbjct: 1649 KTGKASIPLKELEQFNSDI-----------QKLLEPLEAEIQQGVNLKEEDFNKDMNED- 1696
Query: 3833 LRHKDIIDDLVKSGHKIMTACSEEEK-QSMKKKLDKVLKNYDTICQINSERYLQLERAQS 3891
++ + +L++ G + ++E K + +K K + ++ + + S+R +
Sbjct: 1697 --NEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISH 1754
Query: 3892 LVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKM 3951
Q+ ++L L + + ++ LP P + R+++E+ E + +++
Sbjct: 1755 QWYQYKRQADDLLKCLDDIEKKLASLPEP-----------RDERKIKEIDRELQKKKEEL 1803
Query: 3952 NKTGPQLLELSP-GEGFSIQEKYVAADTLYSQIKE---DVKKRAVALDEAISQSTQFHDK 4007
N Q LS G +++ + + +I+ ++ A + + T
Sbjct: 1804 NAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMT 1863
Query: 4008 IDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMI 4067
D LE L + +S + ++++ ++ + D E L E+LK + +
Sbjct: 1864 EDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQ 1923
Query: 4068 ARSGGTDKDISAKA-------------VQDKLDQMVFIWENIHTLVEEREAKLLDVMELA 4114
SG D S K +Q+ L Q+ F WE ++ + ++R+ + +E
Sbjct: 1924 QSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKW 1983
Query: 4115 EKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAET---IREEIDGLQEELDI 4171
+F D + + + F+R + P + E A+ ++E DG+ + +
Sbjct: 1984 RRFHYDIKIFNQWLTEAEQFLRKTQIP--------ENWEHAKYKWYLKELQDGIGQRQTV 2035
Query: 4172 VINL---GSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQD 4228
V L G E+I + D I+++ + LN W + K DR +LEE ++Q
Sbjct: 2036 VRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQR 2095
Query: 4229 GLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELL 4288
L W++ A +AS+ + +K+++E++K E +Q +++LN +
Sbjct: 2096 DLNEFVLWLEEADN-IASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPV 2154
Query: 4289 LKKVT---EESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDEL-- 4343
L EE DK +++ L + L W + + +Q ++E + LGQ + L++L
Sbjct: 2155 LVSAPISPEEQDK--LENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEE 2212
Query: 4344 -----LAWLTHTEGLLS--EQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGN 4396
L WL+ L Q G E E+A V A Q VE + G
Sbjct: 2213 QLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIA--------VQAKQPDVEEILSKGQ 2264
Query: 4397 DLIESSAGEEASNLQNKLEVLNQRWQNV-------------------------------- 4424
L + + ++ KLE L+ W+ V
Sbjct: 2265 HLYKEKPATQP--VKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLV 2322
Query: 4425 -----LEKTEQRKQQLDGALR----QAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPET 4475
++T K ++ +L F+ +L WL+ ++ + + + + G E
Sbjct: 2323 TQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLED 2382
Query: 4476 AKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCP-KSAETNIDQDINNLKEKWESVE 4534
E + E + + L+ Q + + + A T I I ++ +W+ V+
Sbjct: 2383 INEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQ 2442
Query: 4535 TKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKV 4594
L R+ +L E L + ++ + ++ L QA L +D + +I E K
Sbjct: 2443 EHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQ 2502
Query: 4595 FANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLD 4654
A ++ + + + L D + + ++ + W + +R+ ER +L+
Sbjct: 2503 LAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALE 2562
Query: 4655 DARKRAKQFHEAWSKLMEWLEESEKSLD------SELEIANDPDKIKTQLAQHKEFQKSL 4708
+ + +QF K + WL E+E + + + + D +K + Q ++ Q +
Sbjct: 2563 ETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEI 2622
Query: 4709 GAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALL 4768
A VY + + + +DD + L L + KW + KS+ ++ LE +
Sbjct: 2623 EAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSD 2682
Query: 4769 FSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRT------ 4822
+ +LQ L+ WL + +L+ P+ GD V D H+AF++EL +
Sbjct: 2683 QWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMST 2742
Query: 4823 -------------SSVQALKRSARELI--EGSRDDSSWVKVQMQELSTRWETVCALSISK 4867
++ L + REL E +++ + ++ Q +E++T WE + S
Sbjct: 2743 LETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADW 2802
Query: 4868 QTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLE 4927
Q +++ L + +E L L +AE + D LID ++ ++K++
Sbjct: 2803 QRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGD------LLIDSLQDHLEKVK 2856
Query: 4928 EKRAEL 4933
R E+
Sbjct: 2857 ALRGEI 2862
Score = 308 bits (789), Expect = 1e-82
Identities = 502/2696 (18%), Positives = 1071/2696 (39%), Gaps = 346/2696 (12%)
Query: 2690 VKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKV 2749
V +YQ+ L + L ++ L + +S + + Q T + ++ + ++
Sbjct: 216 VNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGN 275
Query: 2750 AQALCEDLSALVK-EEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQM 2808
L L K E + E+ Q+ +L S + + A Q Q Q++
Sbjct: 276 ILQLGSKLIGTGKLSEDEETEVQEQMN-LLNSRWECLRVASMEKQSNLHRVLMDLQNQKL 334
Query: 2809 SRDFQAWLDTKKEEQNKS---HPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGE 2865
++ WL TK EE+ + P+ L+ L+ ++ HK + L Q + ++
Sbjct: 335 -KELNDWL-TKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLE-QEQVRVNSLTHMV 391
Query: 2866 NLLLKTQGSEK-AALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPW 2924
++ ++ G AAL+ QL + W + ++R L++ L K + E+ W
Sbjct: 392 VVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAW 451
Query: 2925 IDKCQNNLEEIKFC--LDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEID 2982
+ + ++ + +I D E +S+ KL L+ ++++ + L + LLS +
Sbjct: 452 LSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLST--LK 509
Query: 2983 KEVVTDENKS-----------LIQKVDMVTEQLH----------SKKFCLENMTQKFKEF 3021
+ VT + ++ L+QK++ T Q+ ++ +E +T
Sbjct: 510 NKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTRE 569
Query: 3022 QEVSK-----------ESKRQLQCAKE---QLDIHDSLGSQAYSNKYLTMLQT------- 3060
Q + K + KRQ+ E +LD+ D ++ + +LQ+
Sbjct: 570 QILVKHAQEELPPPPPQKKRQITVDSEIRKRLDV-DITELHSWITRSEAVLQSPEFAIFR 628
Query: 3061 QQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQ--------VETIAQEHSTLSQQ 3112
++ + LK +V+ +R + + D+ ++ L++ ++I Q L+ +
Sbjct: 629 KEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSR 688
Query: 3113 VDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFL 3172
E C L +L + +QN I ++Q + + + + T + IK+ L
Sbjct: 689 WIEFCQLLSERLNWL-EYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQL 747
Query: 3173 K----KLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREE 3228
K ++ L + +A +E + + D A + ++ QARE+
Sbjct: 748 KICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREK 807
Query: 3229 QVEGTIKRLE--EFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEI 3286
+++ L + + +Q++E + E + Q+L + Q
Sbjct: 808 ELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSS-- 865
Query: 3287 EPLQGKQQDVNWLGQGLIQSAAKSTS--TQGLEHDLDDVNARWKTLNKKVAQRAAQLQEA 3344
LQ +Q + +L + + + K+ S ++ + + +++ RWK L+ ++ + +L+E
Sbjct: 866 --LQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQ 923
Query: 3345 LLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVE 3404
+ + Q+ +++L WM + + + + P + +++K Q+++ +LL + + ++
Sbjct: 924 MNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLN 983
Query: 3405 VIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETL 3464
+ G+KI AEP ++ +L L+++W+ + + R L+G + L
Sbjct: 984 SVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDL 1043
Query: 3465 EPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKV 3524
++EW+T E+ + + +L++ + + K +++ + S+
Sbjct: 1044 SEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIA 1103
Query: 3525 LSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQA-LCNAKIFGEDEVELMNWLNEV 3583
+ ++ ++ +L+ Y + + + + + L++ C ++ E + WLNEV
Sbjct: 1104 QAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLE-KANKWLNEV 1162
Query: 3584 HDKLSKLSVQDYSTEGLWKQQSEL-RVLQEDILLRKQNVDQALLNGLELLKQTTGDEVL- 3641
KL +TE + E+ VL L + + D N + +L QT D +
Sbjct: 1163 EFKLK-------TTENIPGGAEEISEVLDSLENLMRHSEDNP--NQIRILAQTLTDGGVM 1213
Query: 3642 --IIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLH-STH--EELCTWLDK----- 3691
+I ++LE +R++++ + + K LEQ++Q A+ S H +E T++DK
Sbjct: 1214 DELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAY 1273
Query: 3692 ----------------VEVELLSYETQVLK------GEEASQAQM--------------- 3714
++ +L S+E + + G+EA+Q +
Sbjct: 1274 IADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSM 1333
Query: 3715 ------RPKELKKEAKNNKALLD-------------------------------SLNEVS 3737
+P ++ + +K +LD SL+EV
Sbjct: 1334 KFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVK 1393
Query: 3738 SALLELVPWRAREGLEKMVAED----NER-------YRLVSDTITQKVEEIDAAILRSQQ 3786
S + E+V R+ ++K E+ +ER Y + +T++ ++++ + S++
Sbjct: 1394 SEV-EMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRK 1452
Query: 3787 FDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSG 3846
+ + W+ T+ +L + +++ K EI + K + + + G
Sbjct: 1453 MRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVG 1512
Query: 3847 HKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPW 3906
+ T ++E ++ KL + N+ + E L Q + F + + + W
Sbjct: 1513 EALKTVLGKKETL-VEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKW 1571
Query: 3907 LTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEG 3966
+ + +++ E E + QQ+E L+ L AE K++ T Q L G
Sbjct: 1572 IIQADTLLD-------ESEKKKPQQKED-VLKRLKAELNDIRPKVDSTRDQAANLMANRG 1623
Query: 3967 FS----IQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERL 4022
++ + + ++ I +K ++ + + QF+ I ++LE LE +++
Sbjct: 1624 DHCRKLVEPQISELNHRFAAISHRIKTGKASIP--LKELEQFNSDIQKLLEPLEAEIQQ- 1680
Query: 4023 RQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAV 4082
++ + E + ++E+ +V + L QRG+ + R K K
Sbjct: 1681 ----GVNLKEEDFNKDMNEDNEGTV---------KELLQRGDNLQQRITDERKREEIKIK 1727
Query: 4083 QDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPG 4142
Q L + L +R K L++ ++ L+ + D + + L +P
Sbjct: 1728 QQLLQTK---HNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPR 1784
Query: 4143 IDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAW 4202
D +K+ + +EE++ ++ + + L + A EP + + K E+ S +
Sbjct: 1785 -DERKIKEIDRELQKKKEELNAVRRQAE---GLSEDGAAMAVEPTQIQLSKRWREIESKF 1840
Query: 4203 DSLNKAWKDRIDKL-EEAMQAAVQ------------YQDGLQAVFDWVDIAGGKLASMSP 4249
+ +I + EE M + Y + V + L +
Sbjct: 1841 AQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDL 1900
Query: 4250 IGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELK 4309
D E + +Q E LK K Q ++ ++ + L+ T ++ +Q+ L +L
Sbjct: 1901 CAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPV-ERVKLQEALSQLD 1959
Query: 4310 LIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSE-QKPVGGDPKAIE 4368
W+ + + +RQ + + ++ +F + + WLT E L + Q P + +
Sbjct: 1960 FQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYK 2019
Query: 4369 IELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKT 4428
L + LQ+ + Q+ V +N G ++I+ S+ +AS LQ KL LN RWQ V ++
Sbjct: 2020 WYLKE---LQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQL 2076
Query: 4429 EQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLG-GLPETAKEQLNVHMEVC 4487
RK++L+ F ++ + WL + + +AS PL G + KE+L +
Sbjct: 2077 SDRKKRLEEQKNILSEFQRDLNEFVLWLEEADN--IASIPLEPGKEQQLKEKLEQVKLLV 2134
Query: 4488 AAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKE---KWESVETKLNERKTKL 4544
++ K L + G +L P S E D+ N LK+ +W V L E++ ++
Sbjct: 2135 EELPLRQGILKQLNETGGPVLVSAPISPEEQ-DKLENKLKQTNLQWIKVSRALPEKQGEI 2193
Query: 4545 EEALNLAMEFHNSLQDF-------INWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFAN 4597
E + + L+D + WL+ L + ++P+ F + E ++
Sbjct: 2194 EAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPN---QEGPFDVQETEI--- 2247
Query: 4598 EVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGR------ 4651
V + + + E+ G HL + +K +K L + S W K V RL++ R
Sbjct: 2248 AVQAKQPDVEEILSKGQHL--YKEKPATQPVKRKLEDLSSEW-KAVNRLLQELRAKQPDL 2304
Query: 4652 ------------------------------------SLDDARKRAKQFHEAWSKLMEWLE 4675
SL F+ AW++L +WL
Sbjct: 2305 APGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLS 2364
Query: 4676 ESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDN 4735
++ + S+ + D + I + + K + L + + ++LK KTS +
Sbjct: 2365 LLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEAR 2424
Query: 4736 LKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQ 4795
+ D + ++++WD + R+ +L E L S Q+ +A + L + +L +
Sbjct: 2425 TIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWK 2484
Query: 4796 PVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEG-SRDDSSWVKVQMQELS 4854
+D + I K K+L + ++V A +L+ S DD+ V + + ++
Sbjct: 2485 EGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENIN 2544
Query: 4855 TRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRT 4914
W ++ ++ LE R ++F + L WL EAE T VL D R
Sbjct: 2545 ASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTAN---VLQDATRKERL 2601
Query: 4915 LIDQH--KEFMKKLEEKRAELNKATTMGDTV--------LAICHPDSITTIKHWITIIRA 4964
L D KE MK+ ++ + E+ T + + ++ D ++ + +
Sbjct: 2602 LEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNF 2661
Query: 4965 RFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVK 5024
++ E+ + + L ++ L+ LL WLQ + L+ + I + V+
Sbjct: 2662 KWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAP--IGGDFPAVQ 2719
Query: 5025 ALIAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLY 5084
H+ F E+ K+P + +T + I + ++ G ++ LY
Sbjct: 2720 KQNDVHRAFKRELKTKEPVIMSTLETVR------------IFLTEQPLEGLEK-----LY 2762
Query: 5085 PSGSQTQIETKNPRVNLLVSK--------WQQVWLLALERRRKLNDALDRLEELRE 5132
+ E + V L+ K W+++ L + + +RK+++ L+RL+EL+E
Sbjct: 2763 QEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQE 2818
Score = 295 bits (755), Expect = 9e-79
Identities = 474/2585 (18%), Positives = 1053/2585 (40%), Gaps = 294/2585 (11%)
Query: 2574 LEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRK 2633
L ES NL ++QT ++ WL+ E + G +S D ++ Q + + + +
Sbjct: 211 LMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQ 270
Query: 2634 PQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKST 2693
+ + G ++ V+EQ+ + +W+ L ++ + + ++
Sbjct: 271 GRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQ 330
Query: 2694 QYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDA--MNQQLETAQKMKQEIQQEKKQIK--V 2749
+ L+ L+D L+ + + PD + +Q++ + ++++++QE+ ++
Sbjct: 331 NQK--LKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLT 388
Query: 2750 AQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMS 2809
+ D S+ ++ A L QL+ + + ++ + E+ LQ + +
Sbjct: 389 HMVVVVDESS---GDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQ 445
Query: 2810 RDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLL 2869
F AWL K++ NK H KD + +L
Sbjct: 446 CLFSAWLSEKEDAVNKIHTTG---------FKDQNEMLSSL------------------- 477
Query: 2870 KTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWID--- 2926
+ A L+ L KQ + LK+ L LK K + W+D
Sbjct: 478 ----QKLAVLKADLEK--------KKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFA 525
Query: 2927 KCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVV 2986
+C +NL + L+ + + S A + + Q + Q M + T + V +E+
Sbjct: 526 RCWDNLVQ---KLEKSTAQISQA-VTTTQPSLTQTTVMETVTTVTTREQILVKHAQEELP 581
Query: 2987 TDE---------NKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKE 3037
+ + +++D+ +LHS E + Q EF KE KE
Sbjct: 582 PPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQS-PEFAIFRKEG--NFSDLKE 638
Query: 3038 QLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLL 3097
+++ + ++ + LQ +S QAL VE ++G +
Sbjct: 639 KVNAIEREKAEKFRK-----LQDASRSAQAL---------------VEQMVNEG-----V 673
Query: 3098 QVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRD 3157
++I Q L+ + E C L +L + +QN I ++Q + + + +
Sbjct: 674 NADSIKQASEQLNSRWIEFCQLLSERLNWL-EYQNNIIAFYNQLQQLEQMTTTAENWLKI 732
Query: 3158 AETLQKQKETIKAFLK----KLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALS 3213
T + IK+ LK ++ L + +A +E + + D A +
Sbjct: 733 QPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFT 792
Query: 3214 KQCNKLLDRAQAREEQVEGTIKRLE--EFYSKLKEFSILLQKAEEHEESQGPVGMETETI 3271
++ QARE++++ L + + +Q++E + E +
Sbjct: 793 NHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIM 852
Query: 3272 NQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTS--TQGLEHDLDDVNARWKT 3329
Q+L + Q LQ +Q + +L + + + K+ S ++ + + +++ RWK
Sbjct: 853 EQRLGELQALQSS----LQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKK 908
Query: 3330 LNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQ 3389
L+ ++ + +L+E + + Q+ +++L WM + + + + P + +++K Q+++
Sbjct: 909 LSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQC 968
Query: 3390 KLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQ 3449
+LL + + ++ + G+KI AEP ++ +L L+++W+ + + R
Sbjct: 969 RLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEA 1028
Query: 3450 LEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHN 3509
L+G + L ++EW+T E+ + + +L++ + + K +++
Sbjct: 1029 LKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKE 1088
Query: 3510 KHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQA-LCNAKI 3568
+ S+ + ++ ++ +L+ Y + + + + + L++ C ++
Sbjct: 1089 AKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHEL 1148
Query: 3569 FGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSEL-RVLQEDILLRKQNVDQALLN 3627
E + WLNEV KL +TE + E+ VL L + + D N
Sbjct: 1149 LSYLE-KANKWLNEVEFKLK-------TTENIPGGAEEISEVLDSLENLMRHSEDNP--N 1198
Query: 3628 GLELLKQTTGDEVL---IIQDKLEAIKARYKDITKLSTDVAKTLEQALQLA----RRLHS 3680
+ +L QT D + +I ++LE +R++++ + + K LEQ++Q A + LH
Sbjct: 1199 QIRILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHL 1258
Query: 3681 THEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSAL 3740
E L T++DK +L +Y + +A+Q ++++ + +++ L+ + + +
Sbjct: 1259 IQESL-TFIDK---QLAAY---IADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHN--- 1308
Query: 3741 LELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQ---FDQAADAELSW 3797
+ +E ++++++ D +K++++ Q+ F+Q
Sbjct: 1309 ------QGKEAAQRVLSQ--------IDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMI 1354
Query: 3798 ITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEE 3857
+ E + L +L +EQ+ +QL + K ++ ++K+G +I+ E
Sbjct: 1355 LDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTEN 1414
Query: 3858 KQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQL 3917
+ + +++ + +Y+ + +ER QLE+ L + + L WL T +++
Sbjct: 1415 PKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKR 1474
Query: 3918 PAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAAD 3977
A L + + ++ I + K H+ + + G L + + +++K
Sbjct: 1475 SAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKL---- 1530
Query: 3978 TLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKE 4037
+L + V RA +E ++ ++ ++ ++++ I + + Q ++ E EK K
Sbjct: 1531 SLLNSNWIAVTSRA---EEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKP 1587
Query: 4038 QISEN--KNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWEN 4095
Q E+ K + ++ ++P ++ + + ++A G D K V+ ++ ++ +
Sbjct: 1588 QQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRG----DHCRKLVEPQISELNHRFAA 1643
Query: 4096 IHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAA 4155
I ++ +A + ++ E+F D L+ ++ +L++ + + + +
Sbjct: 1644 ISHRIKTGKASI--PLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTV 1701
Query: 4156 ETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDK 4215
+ + + D LQ+ + E + +K L + ++L R K
Sbjct: 1702 KELLQRGDNLQQRI-------------TDERKREEIKIKQQLLQTKHNALKDLRSQRRKK 1748
Query: 4216 LEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQ 4275
E QY+ + +D KLAS+ P D +K+ EL++ K
Sbjct: 1749 ALEISHQWYQYKRQADDLLKCLDDIEKKLASL-PEPRDERKIKEIDRELQKKKE------ 1801
Query: 4276 IEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIIN-------RQHKL-E 4327
E+ + QAE L +E+ V+ ++L W +E + + H + E
Sbjct: 1802 -ELNAVRRQAEGL----SEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVRE 1856
Query: 4328 GALLALG-----QFQHALDELLAWLTHTEGLLSEQKPVGGDP----KAIEIELAKHHVLQ 4378
++ + + + L +TH L E + + P K E + L+
Sbjct: 1857 ETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLK 1916
Query: 4379 N--DVLAHQS-TVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQL 4435
N D L S ++ ++ ++S+ E LQ L L+ +W+ V + + R+ +
Sbjct: 1917 NIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRF 1976
Query: 4436 DGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPET---AKEQLNVHMEVCAAFEA 4492
D ++ + + FH +I+ QWLT+ E+ L ++ +PE AK + + E+
Sbjct: 1977 DRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQ----IPENWEHAKYKWYL-KELQDGIGQ 2031
Query: 4493 KEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAM 4552
++ ++L G++++ + K+ + + + + +L +W+ V +L++RK +LEE N+
Sbjct: 2032 RQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILS 2091
Query: 4553 EFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKT 4612
EF L +F+ WL +A+ ++ P + ++++ K+ E+ + + +L++T
Sbjct: 2092 EFQRDLNEFVLWLEEADNIASIPLEPGK-EQQLKEKLEQVKLLVEELPLRQGILKQLNET 2150
Query: 4613 G----THLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERG-------RSLDDARKRAK 4661
G ++QD ++N L +W KV + L E+ + L K+ +
Sbjct: 2151 GGPVLVSAPISPEEQD--KLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLE 2208
Query: 4662 QFHEAWSKLMEWLEESEKSLDSELEIANDP------DKIKTQL---AQHKEFQKSLGAKH 4712
E + L+ WL + ++LEI N P D +T++ A+ + ++ L
Sbjct: 2209 DLEEQLNHLLLWL----SPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQ 2264
Query: 4713 SVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWD------TICGKS---------- 4756
+Y T ++ L+ + ++ +L ELR K T G S
Sbjct: 2265 HLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQ 2324
Query: 4757 -----------VERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVM 4805
+E + L + F A L DWL ++ + + + GD++ +
Sbjct: 2325 PVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDIN 2384
Query: 4806 NLIDNHKAFQKELGKRTSSVQALKRSARELIE--GSRDDSSWVKVQMQELSTRWETVCAL 4863
+I KA ++L +R ++ L +A+ L +++ + + +++ + +W+ V
Sbjct: 2385 EMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEH 2444
Query: 4864 SISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFM 4923
+++ +L L+ + ++ + L +A L P DA++ I + K+
Sbjct: 2445 LQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLA 2504
Query: 4924 KKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASA 4983
K L + + ++ A + +L D + H IT E + A + +R++
Sbjct: 2505 KDLRQWQTNVDVANDLALKLLRDYSADDTRKV-HMIT------ENINASWRSIHKRVSER 2557
Query: 4984 LAGLIAKQEL-------LEALLAWLQWAETT---LTDKD-KEVIPQEIEEVKALIAEHQT 5032
A L L LE LAWL AETT L D KE + ++ + VK L+ + Q
Sbjct: 2558 EAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQD 2617
Query: 5033 FMEEM 5037
E+
Sbjct: 2618 LQGEI 2622
Score = 277 bits (708), Expect = 2e-73
Identities = 491/2725 (18%), Positives = 1089/2725 (39%), Gaps = 258/2725 (9%)
Query: 2117 QDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVK 2176
Q L+E+L W+ + E +L+ QG++ + ++D + D+ Q + + +
Sbjct: 222 QTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNILQLGS 281
Query: 2177 KFMETTDPST--ASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQT 2234
K + T S + +Q +M L++R+ E + + + ++L ++L
Sbjct: 282 KLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLH--RVLMDLQNQKLKELND 339
Query: 2235 FLETKTQALT---EVDVPGKDVTELSQYMQESTSEFLEHK---KHLEVLHSLLKEISSHG 2288
+L TKT+ T E + G D+ +L + +Q+ HK + LE + ++
Sbjct: 340 WL-TKTEERTRKMEEEPLGPDLEDLKRQVQQ-------HKVLQEDLEQEQVRVNSLTHMV 391
Query: 2289 LPSDKALVLEKTNNLSKKFKEMEDT----IKEKKEAVTSCQEQLDAFQVLVKS---LKSW 2341
+ D++ T L ++ K + D + ++ Q+ L +Q L + +W
Sbjct: 392 VVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAW 451
Query: 2342 IKETTKKVPIVQPSFGAEDLGKSLEDTKKLQ--------------EKWSLKTPEIQKVNN 2387
+ E V + + G +D + L +KL + +SLK + + N
Sbjct: 452 LSEKEDAVNKIHTT-GFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKN 510
Query: 2388 SGIS------LCNLI----SAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSI 2437
++ L N + V K+ A + AV + + T T +T+
Sbjct: 511 KSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQ--AVTTTQPSLTQTTVMETVTTVTT- 567
Query: 2438 KKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTP 2497
++ + H E+L K ++ ++ + + + W+ + Q+P
Sbjct: 568 -REQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVL----QSP 622
Query: 2498 --APTDTEAVKTQVEQN-KSFEAELKQNVNKVQELKDKLTELLEENPDTP-EAPRWKQML 2553
A E + +++ + E E + K+Q+ L+E+ + A KQ
Sbjct: 623 EFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQAS 682
Query: 2554 TEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPN 2613
+++S+W E QL +R LE NN+ F QL+Q E + + +P
Sbjct: 683 EQLNSRWIEFCQLLSERLNWLEYQ-NNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPT 741
Query: 2614 MLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDS 2673
+ +Q + + + + +PQ E+L L G+ P + A T +
Sbjct: 742 AIKSQLKICKDEVNRLSGLQPQIERLKIQSIA-LKEKGQGPMF---LDADFVAFTNHFKQ 797
Query: 2674 LTGQLSDRCDWIDQAI--VKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLE 2731
+ + R + + +YQ + ++ + + KLS T + M Q+L
Sbjct: 798 VFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLG 857
Query: 2732 TAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENH 2791
Q ++ +Q+++ + +++S E + + + E I +K + + H
Sbjct: 858 ELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSE-ISRKYQSEFEEIEGRWKKLSSQLVEH 916
Query: 2792 VQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLT 2851
Q L+ + Q + + W+ + P ++L+ +K + +
Sbjct: 917 CQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQ 976
Query: 2852 AQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKA 2911
G+ + + + + L+ +L + T WD +QV R+ LK LEK
Sbjct: 977 TIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKT 1036
Query: 2912 LKYKEQVETLWPWIDKCQNNLEEIKF-CLDPAEGENSIAKLKSLQKEMDQHFGMVELLNN 2970
+ ++ + + W+ + + E F P E + ++ ++K ++E Q V+LL
Sbjct: 1037 VSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTE 1096
Query: 2971 TANSLLSVCE-IDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESK 3029
+ NS+++ + +E + E ++L + +L+ K LE + + E +++
Sbjct: 1097 SVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKAN 1156
Query: 3030 RQLQCAKEQLDIHDSL-GSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASD 3088
+ L + +L +++ G ++ L L+ + + +Q+ + LAQ L
Sbjct: 1157 KWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRI---LAQTLT----- 1208
Query: 3089 SKGTSDVLL--QVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDD 3146
G D L+ ++ET L ++ + LE +Q + ++ + D
Sbjct: 1209 DGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDK 1268
Query: 3147 ELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIK 3206
+L + DA + ++ + I++ L E ++ EE G +
Sbjct: 1269 QLAAYIADKVDAAQMPQEAQKIQSDLTSHE----------------ISLEEMKKHNQGKE 1312
Query: 3207 RDLEALSKQCNKLLDRAQAREEQVEGTIKRLEE---FYSKLKEFSILLQKAEEHEESQGP 3263
LS+ +D AQ + + V + ++ F +L+E ++L + + H +
Sbjct: 1313 AAQRVLSQ-----IDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALET 1367
Query: 3264 VGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDV 3323
+E E + QLN K + ++ + + V G+ ++Q ++ + + L+ + +
Sbjct: 1368 KSVEQEVVQSQLNHCVNLYKS-LSEVKSEVEMVIKTGRQIVQKK-QTENPKELDERVTAL 1425
Query: 3324 NARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVK 3383
+ L KV +R QL++ L + + + L W+ T+ + + +
Sbjct: 1426 KLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLD 1485
Query: 3384 AQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKA 3443
+++ K Q+ ++ +K ++ I GE + T + + + +LSLL+S W A+ ++A
Sbjct: 1486 SEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETL-VEDKLSLLNSNWIAVTSRA 1544
Query: 3444 ETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALED 3503
E L + F + ++ + +W+ + L E Q E+ + + KA +
Sbjct: 1545 EEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQK--EDVLKRLKAELN 1602
Query: 3504 DIINHNKHLHQAVSIGQSLKVLSSRED--KDMVQSKLD-----FSQVWY-IEIQEKSHSR 3555
DI Q+ ++++R D + +V+ ++ F+ + + I+ + S
Sbjct: 1603 DIRPKVDSTRD-----QAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPL 1657
Query: 3556 SELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQ------QSELRV 3609
EL Q K+ E E+ +N + +K +D EG K+ + R+
Sbjct: 1658 KELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNED--NEGTVKELLQRGDNLQQRI 1715
Query: 3610 LQE---DILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAK 3666
E + + KQ + Q N L+ L+ + L I + K + D+ K D+ K
Sbjct: 1716 TDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEK 1775
Query: 3667 TLEQALQLA--RRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQA-QMRPKELKKEA 3723
L + R++ EL K E+ + + + L + A+ A + +L K
Sbjct: 1776 KLASLPEPRDERKIKEIDRELQK--KKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRW 1833
Query: 3724 KNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNE-RYRLVSDTITQKVEEIDAAIL 3782
+ ++ ++ A + V RE ++ ED V T ++ + A+L
Sbjct: 1834 REIESKFAQFRRLNFAQIHTV----REETMMVMTEDMPLEISYVPSTYLTEITHVSQALL 1889
Query: 3783 RSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDL 3842
+Q A D + K+ SL +I+ Q+S ++ + + L+ ++ +
Sbjct: 1890 EVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERV 1949
Query: 3843 VKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEE 3902
K+ A S+ + Q +K++K+ K+ + E++ + + NQ
Sbjct: 1950 -----KLQEALSQLDFQW--EKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQ------- 1995
Query: 3903 LWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELS 3962
WLTE + + + P E + + ++L++ I + + + +N TG ++++ S
Sbjct: 1996 ---WLTEAEQFLRKTQIP--ENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQS 2050
Query: 3963 PGEGFSI-QEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVER 4021
SI QEK + + + ++ + + R L+E + ++F +++ + LE +
Sbjct: 2051 SKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEE-ADN 2109
Query: 4022 LRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKA 4081
+ P + +++KE++ + K + ++ Q + + L + G ++ + + ++
Sbjct: 2110 IASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEE--QDK 2167
Query: 4082 VQDKLDQMVFIWENIHTLVEER----EAKLLDVMELAEKF-----WCDHMSLIVTIKDTQ 4132
+++KL Q W + + E+ EA++ D+ +L +K +H L++ + +
Sbjct: 2168 LENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNH--LLLWLSPIR 2225
Query: 4133 DFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVK 4192
+ + P + Q+ E A + Q +++ +++ G L +P VK
Sbjct: 2226 NQLEIYNQPNQEGPFDVQETEIA------VQAKQPDVEEILSKGQHLYKE--KPATQPVK 2277
Query: 4193 KSIDELNSAWDSLNKAWKD-----------------------------------RIDKLE 4217
+ +++L+S W ++N+ ++ I KLE
Sbjct: 2278 RKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLE 2337
Query: 4218 EA------MQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEA 4271
+ A + + DW+ + + S + DLE + + I + K +
Sbjct: 2338 MPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDL 2397
Query: 4272 YQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALL 4331
Q++ ++E L A+ L K + + + + D + ++ WD ++E + NR+ +L L
Sbjct: 2398 EQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLK 2457
Query: 4332 ALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAV 4391
Q+ A +E L L K AI+ ++ + L D+ Q+ V+
Sbjct: 2458 DSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVA 2517
Query: 4392 NKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIED 4451
N L+ + ++ + E +N W+++ ++ +R+ L+ R + F ++E
Sbjct: 2518 NDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEK 2577
Query: 4452 LQQWLTDTE------RHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQ 4505
WLT+ E + + L + KE + ++ EA + Y +L + Q
Sbjct: 2578 FLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQ 2637
Query: 4506 QMLARCPKSAE-TNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINW 4564
++L S + + + ++N+ KW + K ++ LE + + H SLQ+ + W
Sbjct: 2638 KILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVW 2697
Query: 4565 LTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQD 4624
L + L+ + V Q D H+ F E+ + I+ +T ++ F +Q
Sbjct: 2698 LQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLET---VRIFLTEQP 2754
Query: 4625 VVLIKNLL-----ISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKL----MEWLE 4675
+ ++ L + + R + V + L RK+A++ + W KL +W
Sbjct: 2755 LEGLEKLYQEPRELPPEERAQNVTRLL----------RKQAEEVNTEWEKLNLHSADWQR 2804
Query: 4676 ESEKSLDSELEIANDPDKIKTQLAQ 4700
+ +++L+ E+ D++ +L Q
Sbjct: 2805 KIDETLERLQELQEATDELDLKLRQ 2829
Score = 226 bits (576), Expect = 5e-58
Identities = 345/1758 (19%), Positives = 713/1758 (40%), Gaps = 172/1758 (9%)
Query: 3339 AQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDD 3398
+ L E+ ++ R+Q ALE +LSW++ E+ + Q S + +VVK Q + L
Sbjct: 209 SSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTA 268
Query: 3399 RKSTVEVIKREGEKIATTAEPA--DKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVV 3456
+ V I + G K+ T + + ++ ++ +Q++LL+SRWE L + + L + +
Sbjct: 269 HQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMD 328
Query: 3457 AQQFHETLEPLNEWLTTIEKRL--VNCEPIGTQASKLEEQIAQHKALEDDI----INHNK 3510
Q ++ L+ LN+WLT E+R + EP+G L+ Q+ QHK L++D+ + N
Sbjct: 329 LQ--NQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNS 386
Query: 3511 HLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFG 3570
H V + +S S ++ +L + I + R LLQ L +
Sbjct: 387 LTHMVVVVDES----SGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLT 442
Query: 3571 EDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLE 3630
E++ WL+E D ++K+ T G Q L LQ+ +L+ LE
Sbjct: 443 EEQCLFSAWLSEKEDAVNKI-----HTTGFKDQNEMLSSLQKLAVLKAD---------LE 488
Query: 3631 LLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLD 3690
KQ+ G + QD L +K + S ++ WLD
Sbjct: 489 KKKQSMGKLYSLKQDLLSTLKNK--------------------------SVTQKTEAWLD 522
Query: 3691 KVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRARE 3750
++ V K E+++ + + + +++++ V++ LV A+E
Sbjct: 523 NF---ARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTREQILVK-HAQE 578
Query: 3751 GLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGD 3810
L ++ ++ D+ +K ++D L SWIT +E L S
Sbjct: 579 ELPP--PPPQKKRQITVDSEIRKRLDVDITELH------------SWITRSEAVLQSPEF 624
Query: 3811 IRLEQDQTSAQLQVQKTFTMEILRHKDI--IDDLVKSGHKIMTACSEE--EKQSMKKKLD 3866
++ + L+ +K +E + + + D +S ++ E S+K+ +
Sbjct: 625 AIFRKEGNFSDLK-EKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASE 683
Query: 3867 KVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYET 3926
++ + CQ+ SER LE +++ F+ ++L T ++ + P E
Sbjct: 684 QLNSRWIEFCQLLSERLNWLEYQNNII-AFYNQLQQLEQMTTTAENWLKIQPTTPSEPTA 742
Query: 3927 LRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKED 3986
++ Q + + ++ +P I+++ L E G F + +VA + Q+ D
Sbjct: 743 IKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMF-LDADFVAFTNHFKQVFSD 801
Query: 3987 VKKRAVALDEAIS--QSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKN 4044
V+ R L ++ + + I +++ +L P + E +++++ E +
Sbjct: 802 VQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQA 861
Query: 4045 VSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEERE 4104
+ +++ Q L +EM S +IS K Q + +++ W+ + + + E
Sbjct: 862 LQSSLQEQQSGLYYLSTTVKEM---SKKAPSEISRK-YQSEFEEIEGRWKKLSSQLVEHC 917
Query: 4105 AKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGI-DPSVVKQQQEAAETIREEID 4163
KL + M K +L + + F+++ E P + D ++K+Q + + +I
Sbjct: 918 QKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKE-EWPALGDSEILKKQLKQCRLLVSDIQ 976
Query: 4164 GLQEELDIVINLGSELIAACGEPD-KPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQA 4222
+Q L+ V N G + I EP+ ++ + ELN+ WD + + R + L+ ++
Sbjct: 977 TIQPSLNSV-NEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEK 1035
Query: 4223 AVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLN 4282
V Q L + +W+ A + + +++ +EE+K+ K EA Q++ +++ L
Sbjct: 1036 TVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLT 1095
Query: 4283 HQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDE 4342
++ + + + ++ L L + L R+ + LE + L++
Sbjct: 1096 ESVNSVIAQAPPVA-QEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEK 1154
Query: 4343 LLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESS 4402
WL E L + + G + I L L+N + + + L +
Sbjct: 1155 ANKWLNEVEFKLKTTENIPGGAEEISEVLDS---LENLMRHSEDNPNQIRILAQTLTDGG 1211
Query: 4403 AGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERH 4462
+E N +LE N RW+ + E+ +R++ L+ +++ A+ + +Q+ LT ++
Sbjct: 1212 VMDELIN--EELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQ 1269
Query: 4463 LLA----SKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETN 4518
L A +P+ A++ + ++ + + EE M+K Q K A
Sbjct: 1270 LAAYIADKVDAAQMPQEAQK---IQSDLTSHEISLEE-----MKKHNQ-----GKEAAQR 1316
Query: 4519 IDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRP 4578
+ I+ ++K + V K F LQ+ L + + L
Sbjct: 1317 VLSQIDVAQKKLQDVSMKF--------RLFQKPANFEQRLQESKMILDEVKMHLPALETK 1368
Query: 4579 SLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSR 4638
S+ + V Q++ ++ + ++ + KTG + Q ++ + + +++
Sbjct: 1369 SVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLH 1428
Query: 4639 WEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQL 4698
+ ++ ++ ER + L+ K +++ + + L EWL ++ L + P + +++
Sbjct: 1429 YNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEV 1488
Query: 4699 AQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVE 4758
A K QK + + + G +L KT L ++D LS L W + ++ E
Sbjct: 1489 AWGKATQKEIEKQKVHLKSITEVGEAL--KTVLGKKETLVEDKLSLLNSNWIAVTSRAEE 1546
Query: 4759 RQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKEL 4818
N L E F + + W+ + + L E + D K + EL
Sbjct: 1547 WLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEK-----KKPQQKEDVLKRLKAEL 1601
Query: 4819 GKRTSSVQALKRSARELIEGSRDD-SSWVKVQMQELSTRWETVCALSISKQTRLEAALRQ 4877
V + + A L+ D V+ Q+ EL+ R+ + K + L++
Sbjct: 1602 NDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAIS--HRIKTGKASIPLKE 1659
Query: 4878 AEEFHSVVHALLEWL-AEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKA 4936
E+F+S + LLE L AE +Q GV +ED + + + ++ +K+L ++ L +
Sbjct: 1660 LEQFNSDIQKLLEPLEAEIQQ-----GVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQR 1714
Query: 4937 TTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIA--KQELL 4994
T R E + +Q Q +AL L + +++ L
Sbjct: 1715 IT------------------------DERKREEIKIKQQLLQTKHNALKDLRSQRRKKAL 1750
Query: 4995 EALLAWLQWAETT------LTDKDKEVI----PQEIEEVKALIAEHQTFMEEMTRKQPDV 5044
E W Q+ L D +K++ P++ ++K + E Q EE+ +
Sbjct: 1751 EISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQA 1810
Query: 5045 DKVTKTYKRRAADPSSLQ 5062
+ +++ A +P+ +Q
Sbjct: 1811 EGLSEDGAAMAVEPTQIQ 1828
Score = 205 bits (521), Expect = 1e-51
Identities = 284/1564 (18%), Positives = 642/1564 (41%), Gaps = 148/1564 (9%)
Query: 3506 INHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCN 3565
++H H Q +++ + + K +S ++Q Y+ + + S
Sbjct: 145 LHHQMHYSQQITVSLAQGYERTSSPKPRFKSYA-YTQAAYVTTSDPTRSPFPSQHLEAPE 203
Query: 3566 AKIFG----EDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQE--------- 3612
K FG E EV L + + + LS L + + + + +++ V+++
Sbjct: 204 DKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYM 263
Query: 3613 -DILLRKQNVDQALLNGLELLK--QTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLE 3669
D+ + V L G +L+ + + DE +Q+++ + +R++ + S + L
Sbjct: 264 MDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLH 323
Query: 3670 QALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKG--EEASQAQMRPKELKKEAKNNK 3727
+ L + + +EL WL K E E + L E+ + + K L+++ + +
Sbjct: 324 RVLMDLQ--NQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQ 381
Query: 3728 ALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQF 3787
++SL + + E A LE+ + +R+ + + + +L+ Q+
Sbjct: 382 VRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRL 441
Query: 3788 DQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGH 3847
+ +W++E E V K T +++ L K
Sbjct: 442 TEEQCLFSAWLSEKEDA-------------------VNKIHTTGFKDQNEMLSSLQKLA- 481
Query: 3848 KIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWL 3907
++ A E++KQSM K LK D + + ++ Q + ++ ++ F ++ L L
Sbjct: 482 -VLKADLEKKKQSMGKLYS--LKQ-DLLSTLKNKSVTQ--KTEAWLDNFARCWDNLVQKL 535
Query: 3908 TETQSIISQLPA---PALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPG 3964
++ + ISQ P+L T+ + +++ +H +++ PQ
Sbjct: 536 EKSTAQISQAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQ--EELPPPPPQ------- 586
Query: 3965 EGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQ 4024
+++ + D+ +++KR LD I++ + + + +L+S E + R
Sbjct: 587 -----KKRQITVDS-------EIRKR---LDVDITELHSWITRSEAVLQSPEFAIFRKE- 630
Query: 4025 PPSISAEVEKIKEQISENKNVSVD-MEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQ 4083
+KE+++ + + KLQ + + E+M+ ++ ++A +++
Sbjct: 631 -----GNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMV------NEGVNADSIK 679
Query: 4084 DKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGI 4143
+Q+ W L+ ER L+ F+ L +++++
Sbjct: 680 QASEQLNSRWIEFCQLLSER-LNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPS 738
Query: 4144 DPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWD 4203
+P+ +K Q + + + GLQ +++ L + IA + P+ +D A+
Sbjct: 739 EPTAIKSQLKICKDEVNRLSGLQPQIE---RLKIQSIALKEKGQGPMF---LDADFVAFT 792
Query: 4204 SLNKAWKDRIDKLEEAMQAA------VQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETV 4257
+ K + E+ +Q ++YQ+ + A+ WV + KL+ TD E +
Sbjct: 793 NHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIM 852
Query: 4258 KQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEE 4317
+Q++ EL+ +S +QQ + L+ + + KK E + Q E++ W L
Sbjct: 853 EQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRK-YQSEFEEIEGRWKKLSS 911
Query: 4318 RIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVL 4377
+++ KLE + L + Q+ + L W+ + L E+ P GD + ++ +L + +L
Sbjct: 912 QLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLL 971
Query: 4378 QNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDG 4437
+D+ Q ++ +VN+ G + + E AS L+ +L+ LN +W ++ ++ RK+ L G
Sbjct: 972 VSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKG 1031
Query: 4438 ALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETY 4497
L + ++ ++ +W+T E L P+ ++ + + KE
Sbjct: 1032 GLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKV 1091
Query: 4498 KSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNS 4557
K L + ++A+ P A+ + +++ L ++ + T+LN + LEE E +
Sbjct: 1092 KLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSY 1151
Query: 4558 LQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLK 4617
L+ WL + E L + + +D + + QI L +T T
Sbjct: 1152 LEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTDGG 1211
Query: 4618 YFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEES 4677
+ LI L + SRW ++ + V R + L+ + + A++ ++ + E L
Sbjct: 1212 VMDE-----LINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFI 1266
Query: 4678 EKSLDSEL-------EIANDPDKIKTQLAQH----KEFQKSLGAKHSVYDTTNRTGRSLK 4726
+K L + + ++ + KI++ L H +E +K K + ++ + K
Sbjct: 1267 DKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQK 1326
Query: 4727 EKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYR 4786
KL D+ + R + K + +L+E+ + + L AL
Sbjct: 1327 ----------KLQDVSMKFR-----LFQKPANFEQRLQESKMILDEVKMHLPAL------ 1365
Query: 4787 VEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSR-DDSSW 4845
E + E + V ++ +NL K L + S V+ + ++ R++++ + ++
Sbjct: 1366 -ETKSVEQEVVQSQLNHCVNL-------YKSLSEVKSEVEMVIKTGRQIVQKKQTENPKE 1417
Query: 4846 VKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVL 4905
+ ++ L + + A ++ +LE L+ + + ++ L EWLA + L +
Sbjct: 1418 LDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAV 1477
Query: 4906 PDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRAR 4965
L + + K K++E+++ L T +G+ + + T ++ ++++ +
Sbjct: 1478 EGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKE-TLVEDKLSLLNSN 1536
Query: 4966 FEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKA 5025
+ V + A++ L + + ++ + W+ A+T L + +K+ Q+ + +K
Sbjct: 1537 WIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKR 1596
Query: 5026 LIAE 5029
L AE
Sbjct: 1597 LKAE 1600
Score = 184 bits (467), Expect = 2e-45
Identities = 494/2698 (18%), Positives = 1056/2698 (39%), Gaps = 384/2698 (14%)
Query: 1210 KLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVF 1269
KLK +N L T+ T+ EEE + D +++ + K + ++++++
Sbjct: 333 KLKELNDWLTKTEE--------RTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRV 384
Query: 1270 HALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIG 1329
++L + + DE + L+ E+ L +RW N+ ++R L+ I
Sbjct: 385 NSLTHMV----VVVDESSGDHATAALE-----EQLKVLGDRWANICRWTEDRWVLLQDI- 434
Query: 1330 KSLKYYRDTYHP--LDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSK 1387
LK+ R T W+ + E KI ++ + + L + +L +++E K+
Sbjct: 435 -LLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQS 493
Query: 1388 MDECQKYAEQYSATVKDYELQTMT------YRAMVDSQQKSPVKRRRMQSSADLIIQEFM 1441
M + + +T+K+ + T + D+ + K S A Q +
Sbjct: 494 MGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSL 553
Query: 1442 DLRTRYTALVTLMTQ---YIKFAGDSLKRLEEEEK---SLEEEKKEHVE-KAKELQKWVS 1494
T + T+ T+ +K A + L ++K +++ E ++ ++ EL W++
Sbjct: 554 TQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWIT 613
Query: 1495 NISKTLKDAE-----KAGKPPFSKQKISS--EEISTKKEQLSEALQTIQLFLAKHGD--- 1544
L+ E K G K+K+++ E + K +L +A ++ Q + + +
Sbjct: 614 RSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGV 673
Query: 1545 -----KMTDEERNE--------LEKQVKTLQESYNLL-FSESLKQLQESQTSGD--VKV- 1587
K E+ N L +++ L+ N++ F L+QL++ T+ + +K+
Sbjct: 674 NADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQ 733
Query: 1588 -----EEKIVAERQQEYKEKLQGICDLLTQTENRLI--------GHQEAFMIGDGTVELK 1634
E + + + K+++ + L Q E I G F+ D
Sbjct: 734 PTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTN 793
Query: 1635 KY-------QSKQEELQKDM--------QGSAQALAEVVKNTENFLKENGEKLSQEDKAL 1679
+ Q++++ELQ Q + A+ V+ +E K + +LS D +
Sbjct: 794 HFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSET--KLSIPQLSVTDYEI 851
Query: 1680 IEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDW 1739
+EQ+L E ++ Q +L+ +QS ++T +KE ++K + E K ++ +
Sbjct: 852 MEQRLGE--LQALQSSLQEQQSGLYY---LSTTVKEMSKKAPS-----EISRKYQSEFEE 901
Query: 1740 LSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQEN 1799
+ K +H Q +E+ Q + + + E DV +
Sbjct: 902 IEGRWKKLSSQLVEHCQKLEE-----QMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALG 956
Query: 1800 LNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYE 1859
++ +K Q ++S Q + + S +K PE +L+ +KEL ++
Sbjct: 957 DSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWD 1016
Query: 1860 TALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKR 1919
+ + + E+ D +E W+ Q+E+E + + L ++
Sbjct: 1017 HMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEE 1076
Query: 1920 QKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRF 1979
K E+ + ++ +T S N V+ A ++ ++++L+ T +
Sbjct: 1077 MKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQ------------EALKKELETLTTNY 1124
Query: 1980 RSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQ 2039
+ L C L K L + + + + LL+ L+ A+K L+E ++ +
Sbjct: 1125 QWL---CTRLNGKCKTLEEVWACWHE----LLSYLE----KANKWLNE--------VEFK 1165
Query: 2040 LEETKALQG---QISSQQVAVEKLKKTAEVLLDARGSLLPAKND-------IQKTLDDIV 2089
L+ T+ + G +IS ++E L + +E + L D I + L+
Sbjct: 1166 LKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTDGGVMDELINEELETFN 1225
Query: 2090 GRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLK-------EQGQVPL 2142
R+ +L + R + L+ ++ + + L + + + ++ L + Q+P
Sbjct: 1226 SRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQ 1285
Query: 2143 NSTALQ-DIISKNIMLEQ---DIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLS 2198
+ +Q D+ S I LE+ G++++ +++ + D S L K +
Sbjct: 1286 EAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFE 1345
Query: 2199 ARFSEASHKHKETLAKMEELKTK--------------VELFENLSE---KLQTFLETKTQ 2241
R E+ E + L+TK V L+++LSE +++ ++T Q
Sbjct: 1346 QRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQ 1405
Query: 2242 ALTEVDVP-------------------GKDVTELSQYMQESTSEFLEHKKHLEVL----- 2277
+ + G VTE Q +++ + +K + VL
Sbjct: 1406 IVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLA 1465
Query: 2278 ---HSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVL 2334
L K + G+PS+ + K+ ++ + +K E + + L + L
Sbjct: 1466 ATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETL 1525
Query: 2335 VKSLKS-----WIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSG 2389
V+ S WI T++ AE+ L + +K E + I K
Sbjct: 1526 VEDKLSLLNSNWIAVTSR----------AEEWLNLLLEYQKHMETFDQNVDHITKWIIQA 1575
Query: 2390 ISLCNLISAVTTPAKAIAAVKSGGAVLNG-----EGTATNTEEFWANKGLTSIKKDMTDI 2444
+L + S P + +K A LN + T AN+G
Sbjct: 1576 DTLLD-ESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRG----------- 1623
Query: 2445 SHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEA 2504
+ L++ +I+ELN + + + + A + L+++ + + Q+ P + E
Sbjct: 1624 ----DHCRKLVEPQISELNHRFAAISHRIKTGKASIP-LKELEQFNSDIQKLLEPLEAEI 1678
Query: 2505 VKTQVEQNKSFEAELKQ-NVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQEL 2563
+ + + F ++ + N V+EL + L + D + K + +K L
Sbjct: 1679 QQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNAL 1738
Query: 2564 NQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQ 2623
L R++K E S+ Q++ L + L + E ++ L P D + +++Q
Sbjct: 1739 KDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASL-PEPRDERKIKEIDRELQ 1797
Query: 2624 ILLQEFATRKPQYEQLTAAGQGILSRP-------------GEDPSLRGIVKEQLAAVTQK 2670
+E + Q E L+ G + P + R + Q+ V ++
Sbjct: 1798 KKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREE 1857
Query: 2671 WDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQL 2730
T + ++ + V ST Y + + +S L +++ L++ + + + +Q
Sbjct: 1858 ----TMMVMTEDMPLEISYVPST-YLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQE 1912
Query: 2731 ETAQKMKQEIQQEKKQIKVAQALCEDLSAL--------VKEEYLKAELSRQLEGILKSFK 2782
E+ + +K +QQ +I + + + +AL VK + ++L Q E + K +K
Sbjct: 1913 ESLKNIKDSLQQSSGRIDIIHS--KKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYK 1970
Query: 2783 DVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSH-PISAKLDVLESLIK 2841
D + + + V+ + F Q + + +L + +N H L L+ I
Sbjct: 1971 DRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKELQDGIG 2030
Query: 2842 DHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERE 2901
+ +TL A GE ++ ++ ++ + LQ +L ++ W KQ+ +R+
Sbjct: 2031 QRQTVVRTLN----------ATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRK 2080
Query: 2902 NKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGE---NSIAKLKSLQKEM 2958
+L+E +++ + W+++ +N+ I L+P + + + ++K L +E+
Sbjct: 2081 KRLEEQKNILSEFQRDLNEFVLWLEEA-DNIASIP--LEPGKEQQLKEKLEQVKLLVEEL 2137
Query: 2959 DQHFGMVELLNNTANSLLSVCEIDKEVVTD-ENK-------------------------- 2991
G+++ LN T +L I E ENK
Sbjct: 2138 PLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQI 2197
Query: 2992 ----SLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKE-----SKRQLQCAKEQLDIH 3042
L +K++ + EQL+ L + + + + + ++E + ++ +Q D+
Sbjct: 2198 KDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVE 2257
Query: 3043 DSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASD---------SKGTS 3093
+ L + K Q ++ L+ L + RL Q+L + D + T
Sbjct: 2258 EILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQ 2317
Query: 3094 DVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAP 3153
V L + + + + +S+ E S L ++ + F E+ + D + S
Sbjct: 2318 TVTLVTQPVVTKETAISKL--EMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRV 2375
Query: 3154 VGRDAETLQ----KQKETIKAFLKK---LEALMASNDN-ANKTCKMMLATEETSPDLVGI 3205
+ D E + KQK T++ ++ LE L+ + N NKT T T
Sbjct: 2376 MVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITD------ 2429
Query: 3206 KRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVG 3265
+E + Q +++ + Q R +Q+ +K ++ +E +L +A ES
Sbjct: 2430 --RIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGP 2487
Query: 3266 METETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNA 3325
+ I +++ K K ++ Q N L L++ + + T+ + +++NA
Sbjct: 2488 YTVDAIQKKITETKQLAK-DLRQWQTNVDVANDLALKLLRDYS-ADDTRKVHMITENINA 2545
Query: 3326 RWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELV-----ANQKPPSAE-F 3379
W++++K+V++R A L+E +F LE L+W+ + E A +K E
Sbjct: 2546 SWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDS 2605
Query: 3380 KVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKIL-KQLSLLDSRWEA 3438
K VK +++ + LQ ++ + +KI + E +D +L ++L ++ +W
Sbjct: 2606 KGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSE 2665
Query: 3439 LLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQH 3498
L K+ LE S ++ H +L+ L WL + L PIG +++Q H
Sbjct: 2666 LRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVH 2725
Query: 3499 KALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSEL 3558
+A + ++ + +S +++++ + + + ++ + + + +E++ + + L
Sbjct: 2726 RAFKRELKTKEPVI---MSTLETVRIFLTEQPLEGLEKL--YQEPRELPPEERAQNVTRL 2780
Query: 3559 LQQALCNAKIFGED-EVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLR 3617
L++ E + +W ++ + L +L +T+ L +L++ Q +++
Sbjct: 2781 LRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDEL-----DLKLRQAEVIKG 2835
Query: 3618 K-QNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQL 3674
Q V L++ L QD LE +KA +I L +V+ + A QL
Sbjct: 2836 SWQPVGDLLIDSL--------------QDHLEKVKALRGEIAPLKENVSHVNDLARQL 2879
Score = 104 bits (259), Expect = 3e-21
Identities = 49/110 (44%), Positives = 73/110 (66%), Gaps = 2/110 (1%)
Query: 189 EDMSAKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAV-QS 247
+ ++++ LL W +Q+T Y + NFTT W DG NA+IH +RPDL D N+V QS
Sbjct: 9 QQTNSEKILLSWVRQSTRNYPQVNVINFTTSWSDGLALNALIHSHRPDLFDWNSVVCQQS 68
Query: 248 NLANLEHAFYVAE-KIGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAFPK 296
LEHAF +A ++G+ +LLDPEDVD + PD+KS++ Y++SL+ P+
Sbjct: 69 ATQRLEHAFNIARYQLGIEKLLDPEDVDTTYPDKKSILMYITSLFQVLPQ 118
Score = 38.9 bits (89), Expect = 0.14
Identities = 46/168 (27%), Positives = 73/168 (43%), Gaps = 27/168 (16%)
Query: 648 VQDLLNWVDEMQVQLDR-TEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMT 706
+Q+LL W+ +L R G D P+V+ +VHRA + E KE I T
Sbjct: 2691 LQELLVWLQLKDDELSRQAPIGGDFPAVQKQ----NDVHRAFKR-ELKTKEPVIMSTLET 2745
Query: 707 APLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYD 766
+ LT + L LE Y + R L RA N + L K+ EEV +
Sbjct: 2746 VRIFLT-EQPLEGLEKLY--------QEPRELPP----EERAQN-VTRLLRKQAEEVNTE 2791
Query: 767 WSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARL 814
W + N + A+ R++D+ E ++ +QE ++L L+ A +
Sbjct: 2792 WEKLNL-------HSADWQRKIDETLERLQELQEATDELDLKLRQAEV 2832
>gi|5032283 dystrophin Dp427m isoform [Homo sapiens]
Length = 3685
Score = 325 bits (832), Expect = 1e-87
Identities = 545/2835 (19%), Positives = 1126/2835 (39%), Gaps = 316/2835 (11%)
Query: 2230 EKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHL-----------EVLH 2278
++ QT LE L + + E+S ++ +F H+ ++ +L
Sbjct: 342 DRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNILQ 401
Query: 2279 SLLKEISSHGLPSDKAL-VLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKS 2337
K I + L D+ V E+ N L+ +++ + EK+ + + +D +K
Sbjct: 402 LGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLH--RVLMDLQNQKLKE 459
Query: 2338 LKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLIS 2397
L W+ +T ++ ++ E LG LED K+ ++ + ++++ SL +++
Sbjct: 460 LNDWLTKTEERTRKMEE----EPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVV 515
Query: 2398 AVTTPA--KAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLL 2455
V + A AA++ VL WAN I ED +LL
Sbjct: 516 VVDESSGDHATAALEEQLKVLGDR---------WAN------------ICRWTEDRWVLL 554
Query: 2456 KDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSF 2515
+D L K Q+ EE WL + K T E + + +++
Sbjct: 555 QDI-------LLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSS-LQKLAVL 606
Query: 2516 EAEL---KQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEI-DSKWQELNQLTIDRQ 2571
+A+L KQ++ K+ LK L L+ T + W D+ Q+L + T
Sbjct: 607 KADLEKKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQIS 666
Query: 2572 QKLEESSNNLTQFQTVEA------------------------------------------ 2589
Q + + +LTQ +E
Sbjct: 667 QAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDV 726
Query: 2590 ---QLKQWLVEKELMV-SVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQG 2645
+L W+ E ++ S + + +++V + +E A + + + + + Q
Sbjct: 727 DITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQA 786
Query: 2646 ILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDK 2705
++ + + +K+ + +W LS+R +W++ + + L+ L
Sbjct: 787 LVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQN-NIIAFYNQLQQLEQM 845
Query: 2706 LSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEE- 2764
+ +N L + P A+ QL+ + + + QI+ + S +KE+
Sbjct: 846 TTTAENWLKIQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQ----SIALKEKG 901
Query: 2765 ----YLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKK 2820
+L A+ + F DV+ + E +Q + ++Q+ + W+ +
Sbjct: 902 QGPMFLDADFVAFTNHFKQVFSDVQAR-EKELQTIFDTLPPM-RYQETMSAIRTWVQQSE 959
Query: 2821 EEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQ 2880
+ + +++E + + + +L Q + + K Q
Sbjct: 960 TKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQ 1019
Query: 2881 LQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLD 2940
+ I+ W + Q+ E KL+E + K K + ++TL W+ + L+E
Sbjct: 1020 SEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEW---- 1075
Query: 2941 PAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTD-----------E 2989
PA G++ I L+K++ Q +V + SL SV E +++ + E
Sbjct: 1076 PALGDSEI-----LKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETE 1130
Query: 2990 NKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQA 3049
K L + D + +Q++++K L+ +K Q+ E + A+E+ D
Sbjct: 1131 LKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERD------ 1184
Query: 3050 YSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTL 3109
+ K LQ + ++ K + K L+ E+ +S + E + +E TL
Sbjct: 1185 FEYKTPDELQKAVEEMKRAKEEAQ-QKEAKVKLLTESVNSVIAQAPPVAQEALKKELETL 1243
Query: 3110 SQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIK 3169
+ C+ L K + + E+ S + + L+ + + E + E I
Sbjct: 1244 TTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEIS 1303
Query: 3170 AFLKKLEALMA-SNDNANKTCKMMLATEETSPDLVG--IKRDLEALSKQCNKLLDRAQAR 3226
L LE LM S DN N+ +LA T ++ I +LE + + +L + A R
Sbjct: 1304 EVLDSLENLMRHSEDNPNQI--RILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRR 1361
Query: 3227 EEQVEGTIKRLEEFYSKL---KEFSILLQK------AEEHEESQGPVGMETETINQQLNM 3277
++ +E +I+ +E L +E + K A++ + +Q P E + I L
Sbjct: 1362 QKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMP--QEAQKIQSDLTS 1419
Query: 3278 FKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQR 3337
++ +E + QGK+ L Q I A K L DV+ +++ L +K A
Sbjct: 1420 HEISLEEMKKHNQGKEAAQRVLSQ--IDVAQKK---------LQDVSMKFR-LFQKPANF 1467
Query: 3338 AAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLD 3397
+LQE+ + + L +L + S E +VV++Q+ L + L
Sbjct: 1468 EQRLQESKMILDEVKMHLPAL--------------ETKSVEQEVVQSQLNHCVNLYKSLS 1513
Query: 3398 DRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVA 3457
+ KS VE++ + G +I + + ++ ++++ L + L K R +QLE ++
Sbjct: 1514 EVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLS 1573
Query: 3458 QQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVS 3517
++ + + L EWL + L + S L+ ++A KA + +I HL
Sbjct: 1574 RKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITE 1633
Query: 3518 IGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELM 3577
+G++LK + +++ +V+ KL +I + ++ LL + + + F ++ +
Sbjct: 1634 VGEALKTVLGKKET-LVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHIT 1692
Query: 3578 NWLNEVHDKL--SKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQT 3635
W+ + L S+ + L + ++EL ++ + + + N + ++
Sbjct: 1693 KWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKL 1752
Query: 3636 TGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVE 3695
++ + + AI R K T ++ K LEQ ++L L+ +E E
Sbjct: 1753 VEPQISELNHRFAAISHRIK--TGKASIPLKELEQFNSDIQKL----------LEPLEAE 1800
Query: 3696 LLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKM 3755
+ + LK E+ + K++ ++ N + + L + + R RE ++
Sbjct: 1801 I--QQGVNLKEEDFN------KDMNED--NEGTVKELLQRGDNLQQRITDERKREEIKIK 1850
Query: 3756 VAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQ 3815
++ + D +Q+ ++ + Q+ + AD L + + EKKL SL + R E+
Sbjct: 1851 QQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDER 1910
Query: 3816 D--QTSAQLQVQKTFTMEILRHKDII--DDLVKSGHKIMTACSEEEKQSMKKKLDKVLKN 3871
+ +LQ +K + R + + D + S+ ++ K N
Sbjct: 1911 KIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLN 1970
Query: 3872 YDTICQINSERYLQLERAQSL-VNQFWETY----EELWPWLTETQSIISQLPAPALEYET 3926
+ I + E + + L ++ TY + L E + +++ A ++E
Sbjct: 1971 FAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFED 2030
Query: 3927 LRQQQEEHRQLRELIAEHKPHIDKMN-KTGPQLLELSPGEGFSIQEKYVAADTLYSQIKE 3985
L +Q+E + +++ + + ID ++ K L +P E +QE D + ++ +
Sbjct: 2031 LFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNK 2090
Query: 3986 DVKKRAVALDEAISQSTQFHDKI---DQILESLERIVERLRQPPSISAEVEKIKEQISEN 4042
K R D ++ + +FH I +Q L E+ + + + P + E K K + E
Sbjct: 2091 MYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENW--EHAKYKWYLKEL 2148
Query: 4043 KNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEE 4102
++ + + Q + TL GEE+I +S TD I +Q+KL + W+ + + +
Sbjct: 2149 QD---GIGQRQTVVRTLNATGEEIIQQSSKTDASI----LQEKLGSLNLRWQEVCKQLSD 2201
Query: 4103 REAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEI 4162
R+ +L + + +F D ++ +++ + +PG + + K++ E + + EE+
Sbjct: 2202 RKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQL-KEKLEQVKLLVEEL 2260
Query: 4163 DGLQEELDIVINLGSELIAACG----EPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEE 4218
Q L + G ++ + E DK ++ + + N W +++A ++ ++E
Sbjct: 2261 PLRQGILKQLNETGGPVLVSAPISPEEQDK--LENKLKQTNLQWIKVSRALPEKQGEIEA 2318
Query: 4219 AMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEE----LKQFKSEAYQQ 4274
++ Q + L+ D + L +SPI LE Q +E +++ + +
Sbjct: 2319 QIKDLGQLEKKLE---DLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAK 2375
Query: 4275 QIEMERLNHQAELLLK-KVTEESDKHTVQDPLMELKLIWDSLEER--------------- 4318
Q ++E + + + L K K + K ++D E K + L+E
Sbjct: 2376 QPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIG 2435
Query: 4319 -------------IINRQ---HKLE--GALL----ALGQFQHALDELLAWLTHTEGLLSE 4356
++ ++ KLE +L+ AL F A EL WL+ + ++
Sbjct: 2436 ASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKS 2495
Query: 4357 QKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNL-QNKLE 4415
Q+ + GD + I + K D+ + +E + A +L ++ +EA + +++E
Sbjct: 2496 QRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIE 2555
Query: 4416 VLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPET 4475
+ +W V E + R+QQL+ L+ + + E+ +Q L L + K +
Sbjct: 2556 RIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDA 2615
Query: 4476 AKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVET 4535
++++ ++ + ++L + N+ W S+
Sbjct: 2616 IQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHK 2675
Query: 4536 KLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNV---ASRPSLILDT---VLFQI 4589
+++ER+ LEE L +F L+ F+ WLT+AE T NV A+R +L+ V +
Sbjct: 2676 RVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELM 2735
Query: 4590 DEHKVFANEVNSHREQIIELDKTGTH-LKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVE 4648
+ + E+ +H + LD+ L+ D VL++ L ++ +W ++ ++ +
Sbjct: 2736 KQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLN 2795
Query: 4649 RGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSL 4708
L+ + + K+ H + +L+ WL+ + L + I D ++ Q H+ F++ L
Sbjct: 2796 IRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKREL 2855
Query: 4709 GAKHSVYDTTNRT-------------------GRSLKEKTSLADDNLKLDDMLSELRDKW 4749
K V +T T R L + + L E+ +W
Sbjct: 2856 KTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEW 2915
Query: 4750 DTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGD--IDLVMNL 4807
+ + S + Q K++E L + +A L L + E QPV GD ID + +
Sbjct: 2916 EKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPV-GDLLIDSLQDH 2974
Query: 4808 IDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISK 4867
++ KA + E+ +V + AR+L S + +++L+TRW+ +
Sbjct: 2975 LEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLL------- 3027
Query: 4868 QTRLEAALRQAEEFH 4882
Q +E +RQ E H
Sbjct: 3028 QVAVEDRVRQLHEAH 3042
Score = 316 bits (809), Expect = 5e-85
Identities = 548/2809 (19%), Positives = 1128/2809 (40%), Gaps = 353/2809 (12%)
Query: 1879 LEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYIT 1938
L+++ E WL +E L+ ++D+ + + + + D+ +H+G + I
Sbjct: 341 LDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNIL 400
Query: 1939 ISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVD 1998
G++++ K + EVQ +++ R+ L +NL ++
Sbjct: 401 QLGSKLIGTGKLSEDEE----------TEVQEQMNLLNSRWECLRVASMEKQSNLHRVLM 450
Query: 1999 KYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVE 2058
Q+ + L L E K EP+ D ++L+RQ+++ K LQ + +QV V
Sbjct: 451 DLQNQKLKE--LNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVN 508
Query: 2059 KLKKTAEVLLDARGSLLPAKNDIQ-KTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQ 2117
L V+ ++ G A + Q K L D R+ ++ + +R LQ L + +
Sbjct: 509 SLTHMVVVVDESSGDHATAALEEQLKVLGD---RWANICRWTEDRWVLLQDILLKWQRLT 565
Query: 2118 DGLDEMLDWMGNVESSLKEQGQVPLNSTALQD------IISKNIMLEQDIAGRQSSINAM 2171
+ W+ E ++ + +++T +D + K +L+ D+ ++ S+ +
Sbjct: 566 EEQCLFSAWLSEKEDAVNK-----IHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKL 620
Query: 2172 NEKVKKFMETT-DPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSE 2230
+ + T + S +A + + + + K +++ A++ + T + +L++
Sbjct: 621 YSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQ--PSLTQ 678
Query: 2231 KLQTFLETKTQALTEVDVPGKDVTEL-----SQYMQESTSEFLEHKKHLEV----LHSLL 2281
T +ET T T + K E Q ++ T + E +K L+V LHS +
Sbjct: 679 T--TVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDS-EIRKRLDVDITELHSWI 735
Query: 2282 KEISSHGLPSDKALVLEKTNNLS--------------KKFKEMEDTIKEKK--------- 2318
S L S + + K N S +KF++++D + +
Sbjct: 736 TR-SEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNE 794
Query: 2319 ----EAVTSCQEQLDA----FQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKK 2370
+++ EQL++ F L+ +W++ + E + + E+ K
Sbjct: 795 GVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLK 854
Query: 2371 LQEKWSLKTPEIQKVNNSGISLC-NLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFW 2429
+Q TP S + +C + ++ ++ I +K L +G
Sbjct: 855 IQPT----TPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKG--------- 901
Query: 2430 ANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKL--QKAQEESSAMMQWLQKMN 2487
+G + D ++ ++ + ++ + EL T L + QE SA+ W+Q+ +
Sbjct: 902 --QGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQ-S 958
Query: 2488 KTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAP 2547
+T Q TD E ++ ++ + ++ ++ L++ + + L + E+ ++ P + +
Sbjct: 959 ETKLSIPQLSV-TDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAP-SEISR 1016
Query: 2548 RWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGP 2607
+++ EI+ +W++L+ ++ QKLEE N L + Q LK+W+ E ++ + P
Sbjct: 1017 KYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWP 1076
Query: 2608 LSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAV 2667
D +L Q +Q ++L+ + T +P + GQ I + +P ++ +L +
Sbjct: 1077 ALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEA--EPEFASRLETELKEL 1134
Query: 2668 TQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMN 2727
+WD + Q+ R + + + K+ Q L + + ++ + + PD +
Sbjct: 1135 NTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQ 1194
Query: 2728 QQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAE--LSRQLEGILKSFKDVE 2785
+ +E ++ K+E QQ++ ++K+ L E +++++ + A+ L ++LE + +++ +
Sbjct: 1195 KAVEEMKRAKEEAQQKEAKVKL---LTESVNSVIAQAPPVAQEALKKELETLTTNYQWLC 1251
Query: 2786 QKAENHVQHLQSACASSHQFQQMSRDFQAWLD-------TKKEEQNKSHPISAKLDVLES 2838
+ + L+ A H+ WL+ T + + IS LD LE+
Sbjct: 1252 TRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLEN 1311
Query: 2839 LIKDHKD-------FSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQ--------- 2882
L++ +D ++TLT M E E E + + + A++ Q
Sbjct: 1312 LMRHSEDNPNQIRILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQS 1371
Query: 2883 -------LNTIKTNWDTFNKQVK-------------ERENKLKE-------SLEKALKY- 2914
L+ I+ + +KQ+ + K++ SLE+ K+
Sbjct: 1372 AQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHN 1431
Query: 2915 --KEQVETLWPWIDKCQNNLEEI--KFCL--DPAEGENSIAKLKSLQKEMDQHFGMVEL- 2967
KE + + ID Q L+++ KF L PA E + + K + E+ H +E
Sbjct: 1432 QGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETK 1491
Query: 2968 ----------LNNTANSLLSVCEIDKEV--VTDENKSLIQKVDMVTEQLHSKKFCLENMT 3015
LN+ N S+ E+ EV V + ++QK +Q + K E +T
Sbjct: 1492 SVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQK-----KQTENPKELDERVT 1546
Query: 3016 QKFKEFQEVSK---ESKRQLQ-CAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQ 3071
+ E+ E K+QL+ C K + + M T++ +++ +
Sbjct: 1547 ALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSN 1606
Query: 3072 VDL----AKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGI 3127
+D K +++ + K ++V ++T+ + TL V++K S L + +
Sbjct: 1607 LDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETL---VEDKLSLLNSNWIAV 1663
Query: 3128 G----HFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASND 3183
+ N + E FD +D + A+TL + E K K+ + L
Sbjct: 1664 TSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKE-DVLKRLKA 1722
Query: 3184 NANKTCKMMLATEETSPDLVGIKRD--LEALSKQCNKLLDRAQAREEQVEG-----TIKR 3236
N + +T + + +L+ + D + + Q ++L R A +++ +K
Sbjct: 1723 ELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKE 1782
Query: 3237 LEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDV 3296
LE+F S +++ LL+ E E Q V ++ E N+ +N E +G +++
Sbjct: 1783 LEQFNSDIQK---LLEPLEA--EIQQGVNLKEEDFNKDMN----------EDNEGTVKEL 1827
Query: 3297 NWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALE 3356
G L Q + ++ + + L +QR + E +++ +
Sbjct: 1828 LQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQAD 1887
Query: 3357 SLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKI--- 3413
LL + D E+ +A+ P E K+ K + R L +K + ++R+ E +
Sbjct: 1888 DLLKCLDDIEKKLASLPEPRDERKI--------KEIDRELQKKKEELNAVRRQAEGLSED 1939
Query: 3414 --ATTAEPADKVKILKQLSLLDSRWEAL--LNKAE------------TRNRQLEGISVVA 3457
A EP ++++ K+ ++S++ LN A+ T + LE IS V
Sbjct: 1940 GAAMAVEPT-QIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLE-ISYVP 1997
Query: 3458 QQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHL---HQ 3514
+ + +++ L +E+ L + L +Q K ++D + + + H
Sbjct: 1998 STYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHS 2057
Query: 3515 AVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEV 3574
+ R S+LDF + ++ + R +++ + F D
Sbjct: 2058 KKTAALQSATPVERVKLQEALSQLDFQ---WEKVNKMYKDRQGRFDRSVEKWRRFHYDIK 2114
Query: 3575 ELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQ 3634
WL E L K + + +K L+ LQ+ I R+ V G E+++Q
Sbjct: 2115 IFNQWLTEAEQFLRKTQIPENWEHAKYKWY--LKELQDGIGQRQTVVRTLNATGEEIIQQ 2172
Query: 3635 TTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEV 3694
++ + I+Q+KL ++ R++++ K +D K LE+ + E WL++ +
Sbjct: 2173 SSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEAD- 2231
Query: 3695 ELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREG--L 3752
+ S + K ++ + + K L +E + +L LNE +L P E L
Sbjct: 2232 NIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKL 2291
Query: 3753 EKMVAEDNERYRLVSDTITQKVEEIDAAIL-------RSQQFDQAADAELSWITETEKKL 3805
E + + N ++ VS + +K EI+A I + + ++ + L W++ +L
Sbjct: 2292 ENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQL 2351
Query: 3806 MSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKL 3865
Q VQ+T + D+ + L K H + Q +K+KL
Sbjct: 2352 EIYN-----QPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYK---EKPATQPVKRKL 2403
Query: 3866 DKVLKNYDTICQINSE-RYLQLERAQ-------------SLVNQFWETYEELWPWLTETQ 3911
+ + + + ++ E R Q + A +LV Q T E L
Sbjct: 2404 EDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPS 2463
Query: 3912 SIISQLPAPA--------------LEYETLRQQQE---EHRQLRELIAEHKPHIDKMNKT 3954
S++ ++PA A L + ++ Q+ + + E+I + K + + +
Sbjct: 2464 SLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQR 2523
Query: 3955 GPQLLEL-----------SPGEGFSI-QEKYVAADTLYSQIKEDVKKRAVALDEAISQST 4002
PQL EL S E +I ++ + +++E ++ R L+E + ST
Sbjct: 2524 RPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDST 2583
Query: 4003 QF---HDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETL 4059
Q+ ++ +Q+L +E ++ P V+ I+++I+E K ++ D+ + Q +
Sbjct: 2584 QWLEAKEEAEQVLGQARAKLESWKEGPYT---VDAIQKKITETKQLAKDLRQWQTNVDVA 2640
Query: 4060 KQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWC 4119
+++ R D + + ++ W +IH V EREA L + L ++F
Sbjct: 2641 NDLALKLL-RDYSADDTRKVHMITENINAS---WRSIHKRVSEREAALEETHRLLQQFPL 2696
Query: 4120 DHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEEL----DIVINL 4175
D + + + + L+D +++ + E +++ D LQ E+ D+ NL
Sbjct: 2697 DLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQD-LQGEIEAHTDVYHNL 2755
Query: 4176 GSE----LIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQ 4231
L + G D ++++ +D +N W L K + LE + + LQ
Sbjct: 2756 DENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQ 2815
Query: 4232 AVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAY------------------Q 4273
+ W+ + +L+ +PIG D V++Q + + FK E +
Sbjct: 2816 ELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTE 2875
Query: 4274 QQIE-MERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLA 4332
Q +E +E+L + L + ++ ++ E+ W+ L + Q K++ L
Sbjct: 2876 QPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLER 2935
Query: 4333 LGQFQHALDELLAWLTHTEGLLSEQKPVGG-DPKAIEIELAKHHVLQNDVLAHQSTVEAV 4391
L + Q A DEL L E + +PVG +++ L K L+ ++ + V V
Sbjct: 2936 LQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHV 2995
Query: 4392 NKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALR 4440
N L NL + LE LN RW+ + E R +QL A R
Sbjct: 2996 NDLARQLTTLGIQLSPYNL-STLEDLNTRWKLLQVAVEDRVRQLHEAHR 3043
Score = 313 bits (803), Expect = 2e-84
Identities = 505/2706 (18%), Positives = 1066/2706 (39%), Gaps = 308/2706 (11%)
Query: 2413 GAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKA 2472
G+ L G G + EE T +++ M ++ +E L + +K + L+ L LQ
Sbjct: 403 GSKLIGTGKLSEDEE-------TEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQN- 454
Query: 2473 QEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDK 2532
++ + WL K + K ++ P D E +K QV+Q+K + +L+Q +V L
Sbjct: 455 -QKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHM 513
Query: 2533 LTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLK 2592
+ + E + D A +Q L + +W + + T DR L++ + +
Sbjct: 514 VVVVDESSGDHATAALEEQ-LKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFS 572
Query: 2593 QWLVEKELMVSVLGPLSI-DPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPG 2651
WL EKE V+ + D N + + Q++ +L + +K +L + Q +LS
Sbjct: 573 AWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTL- 631
Query: 2652 EDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKS-----------------TQ 2694
++ S+ + L + WD+L +L I QA+ + T+
Sbjct: 632 KNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTR 691
Query: 2695 YQSLLRSLSDKLSD----------LDNKLSSSLAVS--------THPDAMNQQLETAQKM 2736
Q L++ ++L +D+++ L V T +A+ Q E A
Sbjct: 692 EQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFR 751
Query: 2737 KQ-----------EIQQEKKQ--------IKVAQALCEDL-SALVKEEYLKAELSRQLEG 2776
K+ I++EK + + AQAL E + + V + +K + S QL
Sbjct: 752 KEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIK-QASEQLNS 810
Query: 2777 ILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPIS-AKLDV 2835
F + + N +++ + A +Q QQ+ + + T E K P + ++
Sbjct: 811 RWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQ-----MTTTAENWLKIQPTTPSEPTA 865
Query: 2836 LESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNK 2895
++S +K KD L+ E+ + +++ LK +G L ++
Sbjct: 866 IKSQLKICKDEVNRLSGLQPQIERL--KIQSIALKEKGQGPMFLDADFVAFTNHFKQVFS 923
Query: 2896 QVKERENKLKESLEKA--LKYKEQVETLWPWIDKCQNNLEEIKFCLDPAE-GENSIAKLK 2952
V+ RE +L+ + ++Y+E + + W+ + + L + + E E + +L+
Sbjct: 924 DVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQ 983
Query: 2953 SLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLE 3012
+LQ + + + L+ T V E+ K+ ++ ++ + + + + L
Sbjct: 984 ALQSSLQEQQSGLYYLSTT------VKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLV 1037
Query: 3013 NMTQKFKEFQEVSKESKRQLQCAKE---QLDIH-----DSLGSQAYSNKYLTMLQTQQKS 3064
QK +E ++ + +Q K+ ++D+ +LG K L +
Sbjct: 1038 EHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSD 1097
Query: 3065 LQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKL 3124
+Q ++ ++ Q + EA + + S + +++ + + + QQV + L+ L
Sbjct: 1098 IQTIQPSLNSVNEGGQKIKNEA-EPEFASRLETELKELNTQWDHMCQQVYARKEALKGGL 1156
Query: 3125 QGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDN 3184
+ Q + EM + ++E + + LQK E +K A +
Sbjct: 1157 EKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKR---------AKEEA 1207
Query: 3185 ANKTCKMMLATEETSPDLV--------GIKRDLEALSKQCNKLLDRAQAREEQVEGTIKR 3236
K K+ L TE + + +K++LE L+ L R + + +E
Sbjct: 1208 QQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWAC 1267
Query: 3237 LEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDV 3296
E S L++ + L + E ++ + E I++ L+ + + + +
Sbjct: 1268 WHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHS----EDNPNQI 1323
Query: 3297 NWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALE 3356
L Q L + + +L+ N+RW+ L+++ +R L++++ Q A E
Sbjct: 1324 RILAQTLTDGGVMD---ELINEELETFNSRWRELHEEAVRRQKLLEQSI------QSAQE 1374
Query: 3357 SLLSWMVDTEELVANQKPPSAEF--KVVKAQI-QEQKLLQRLLDDRKSTVEVIKREGEKI 3413
+ S + E L K +A KV AQ+ QE + +Q L + ++E +K+ +
Sbjct: 1375 TEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGK 1434
Query: 3414 ATTAEPADKVKIL-KQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLT 3472
++ + K+L + ++ A R E + L+ + L
Sbjct: 1435 EAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMI--------LDEVKMHLP 1486
Query: 3473 TIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKD 3532
+E + V E + +Q L + +K+L + + + G+ + E+
Sbjct: 1487 ALETKSVEQEVVQSQ---LNHCVNLYKSLSEV----KSEVEMVIKTGRQIVQKKQTENPK 1539
Query: 3533 MVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSV 3592
+ ++ ++ Y E+ K R + L++ L ++ ++ L WL +L+K S
Sbjct: 1540 ELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSA 1599
Query: 3593 QDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKA 3652
+ L + + + Q++I +K ++ G E LK G + +++DKL + +
Sbjct: 1600 VEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVG-EALKTVLGKKETLVEDKLSLLNS 1658
Query: 3653 RYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQA 3712
+ +T + + L + + + + W+ ++ + L E++ K ++
Sbjct: 1659 NWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWI--IQADTLLDESEKKKPQQKEDV 1716
Query: 3713 QMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQ 3772
K LK E + + +DS + ++ L+ R+ +E ++E N R+ +S I
Sbjct: 1717 L---KRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRI-- 1771
Query: 3773 KVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEI 3832
K + + +QF+ +KL+ + ++Q + K +
Sbjct: 1772 KTGKASIPLKELEQFNSDI-----------QKLLEPLEAEIQQGVNLKEEDFNKDMNED- 1819
Query: 3833 LRHKDIIDDLVKSGHKIMTACSEEEK-QSMKKKLDKVLKNYDTICQINSERYLQLERAQS 3891
++ + +L++ G + ++E K + +K K + ++ + + S+R +
Sbjct: 1820 --NEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISH 1877
Query: 3892 LVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKM 3951
Q+ ++L L + + ++ LP P + R+++E+ E + +++
Sbjct: 1878 QWYQYKRQADDLLKCLDDIEKKLASLPEP-----------RDERKIKEIDRELQKKKEEL 1926
Query: 3952 NKTGPQLLELSP-GEGFSIQEKYVAADTLYSQIKE---DVKKRAVALDEAISQSTQFHDK 4007
N Q LS G +++ + + +I+ ++ A + + T
Sbjct: 1927 NAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMT 1986
Query: 4008 IDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMI 4067
D LE L + +S + ++++ ++ + D E L E+LK + +
Sbjct: 1987 EDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQ 2046
Query: 4068 ARSGGTDKDISAKA-------------VQDKLDQMVFIWENIHTLVEEREAKLLDVMELA 4114
SG D S K +Q+ L Q+ F WE ++ + ++R+ + +E
Sbjct: 2047 QSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKW 2106
Query: 4115 EKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAET---IREEIDGLQEELDI 4171
+F D + + + F+R + P + E A+ ++E DG+ + +
Sbjct: 2107 RRFHYDIKIFNQWLTEAEQFLRKTQIP--------ENWEHAKYKWYLKELQDGIGQRQTV 2158
Query: 4172 VINL---GSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQD 4228
V L G E+I + D I+++ + LN W + K DR +LEE ++Q
Sbjct: 2159 VRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQR 2218
Query: 4229 GLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELL 4288
L W++ A +AS+ + +K+++E++K E +Q +++LN +
Sbjct: 2219 DLNEFVLWLEEADN-IASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPV 2277
Query: 4289 LKKVT---EESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDEL-- 4343
L EE DK +++ L + L W + + +Q ++E + LGQ + L++L
Sbjct: 2278 LVSAPISPEEQDK--LENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEE 2335
Query: 4344 -----LAWLTHTEGLLS--EQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGN 4396
L WL+ L Q G E E+A V A Q VE + G
Sbjct: 2336 QLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIA--------VQAKQPDVEEILSKGQ 2387
Query: 4397 DLIESSAGEEASNLQNKLEVLNQRWQNV-------------------------------- 4424
L + + ++ KLE L+ W+ V
Sbjct: 2388 HLYKEKPATQP--VKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLV 2445
Query: 4425 -----LEKTEQRKQQLDGALR----QAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPET 4475
++T K ++ +L F+ +L WL+ ++ + + + + G E
Sbjct: 2446 TQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLED 2505
Query: 4476 AKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCP-KSAETNIDQDINNLKEKWESVE 4534
E + E + + L+ Q + + + A T I I ++ +W+ V+
Sbjct: 2506 INEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQ 2565
Query: 4535 TKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKV 4594
L R+ +L E L + ++ + ++ L QA L +D + +I E K
Sbjct: 2566 EHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQ 2625
Query: 4595 FANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLD 4654
A ++ + + + L D + + ++ + W + +R+ ER +L+
Sbjct: 2626 LAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALE 2685
Query: 4655 DARKRAKQFHEAWSKLMEWLEESEKSLD------SELEIANDPDKIKTQLAQHKEFQKSL 4708
+ + +QF K + WL E+E + + + + D +K + Q ++ Q +
Sbjct: 2686 ETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEI 2745
Query: 4709 GAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALL 4768
A VY + + + +DD + L L + KW + KS+ ++ LE +
Sbjct: 2746 EAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSD 2805
Query: 4769 FSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRT------ 4822
+ +LQ L+ WL + +L+ P+ GD V D H+AF++EL +
Sbjct: 2806 QWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMST 2865
Query: 4823 -------------SSVQALKRSARELI--EGSRDDSSWVKVQMQELSTRWETVCALSISK 4867
++ L + REL E +++ + ++ Q +E++T WE + S
Sbjct: 2866 LETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADW 2925
Query: 4868 QTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLE 4927
Q +++ L + +E L L +AE + D LID ++ ++K++
Sbjct: 2926 QRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGD------LLIDSLQDHLEKVK 2979
Query: 4928 EKRAEL 4933
R E+
Sbjct: 2980 ALRGEI 2985
Score = 308 bits (789), Expect = 1e-82
Identities = 502/2696 (18%), Positives = 1071/2696 (39%), Gaps = 346/2696 (12%)
Query: 2690 VKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKV 2749
V +YQ+ L + L ++ L + +S + + Q T + ++ + ++
Sbjct: 339 VNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGN 398
Query: 2750 AQALCEDLSALVK-EEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQM 2808
L L K E + E+ Q+ +L S + + A Q Q Q++
Sbjct: 399 ILQLGSKLIGTGKLSEDEETEVQEQMN-LLNSRWECLRVASMEKQSNLHRVLMDLQNQKL 457
Query: 2809 SRDFQAWLDTKKEEQNKS---HPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGE 2865
++ WL TK EE+ + P+ L+ L+ ++ HK + L Q + ++
Sbjct: 458 -KELNDWL-TKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLE-QEQVRVNSLTHMV 514
Query: 2866 NLLLKTQGSEK-AALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPW 2924
++ ++ G AAL+ QL + W + ++R L++ L K + E+ W
Sbjct: 515 VVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAW 574
Query: 2925 IDKCQNNLEEIKFC--LDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEID 2982
+ + ++ + +I D E +S+ KL L+ ++++ + L + LLS +
Sbjct: 575 LSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLST--LK 632
Query: 2983 KEVVTDENKS-----------LIQKVDMVTEQLH----------SKKFCLENMTQKFKEF 3021
+ VT + ++ L+QK++ T Q+ ++ +E +T
Sbjct: 633 NKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTRE 692
Query: 3022 QEVSK-----------ESKRQLQCAKE---QLDIHDSLGSQAYSNKYLTMLQT------- 3060
Q + K + KRQ+ E +LD+ D ++ + +LQ+
Sbjct: 693 QILVKHAQEELPPPPPQKKRQITVDSEIRKRLDV-DITELHSWITRSEAVLQSPEFAIFR 751
Query: 3061 QQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQ--------VETIAQEHSTLSQQ 3112
++ + LK +V+ +R + + D+ ++ L++ ++I Q L+ +
Sbjct: 752 KEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSR 811
Query: 3113 VDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFL 3172
E C L +L + +QN I ++Q + + + + T + IK+ L
Sbjct: 812 WIEFCQLLSERLNWL-EYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQL 870
Query: 3173 K----KLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREE 3228
K ++ L + +A +E + + D A + ++ QARE+
Sbjct: 871 KICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREK 930
Query: 3229 QVEGTIKRLE--EFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEI 3286
+++ L + + +Q++E + E + Q+L + Q
Sbjct: 931 ELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSS-- 988
Query: 3287 EPLQGKQQDVNWLGQGLIQSAAKSTS--TQGLEHDLDDVNARWKTLNKKVAQRAAQLQEA 3344
LQ +Q + +L + + + K+ S ++ + + +++ RWK L+ ++ + +L+E
Sbjct: 989 --LQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQ 1046
Query: 3345 LLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVE 3404
+ + Q+ +++L WM + + + + P + +++K Q+++ +LL + + ++
Sbjct: 1047 MNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLN 1106
Query: 3405 VIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETL 3464
+ G+KI AEP ++ +L L+++W+ + + R L+G + L
Sbjct: 1107 SVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDL 1166
Query: 3465 EPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKV 3524
++EW+T E+ + + +L++ + + K +++ + S+
Sbjct: 1167 SEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIA 1226
Query: 3525 LSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQA-LCNAKIFGEDEVELMNWLNEV 3583
+ ++ ++ +L+ Y + + + + + L++ C ++ E + WLNEV
Sbjct: 1227 QAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLE-KANKWLNEV 1285
Query: 3584 HDKLSKLSVQDYSTEGLWKQQSEL-RVLQEDILLRKQNVDQALLNGLELLKQTTGDEVL- 3641
KL +TE + E+ VL L + + D N + +L QT D +
Sbjct: 1286 EFKLK-------TTENIPGGAEEISEVLDSLENLMRHSEDNP--NQIRILAQTLTDGGVM 1336
Query: 3642 --IIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLH-STH--EELCTWLDK----- 3691
+I ++LE +R++++ + + K LEQ++Q A+ S H +E T++DK
Sbjct: 1337 DELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAY 1396
Query: 3692 ----------------VEVELLSYETQVLK------GEEASQAQM--------------- 3714
++ +L S+E + + G+EA+Q +
Sbjct: 1397 IADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSM 1456
Query: 3715 ------RPKELKKEAKNNKALLD-------------------------------SLNEVS 3737
+P ++ + +K +LD SL+EV
Sbjct: 1457 KFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVK 1516
Query: 3738 SALLELVPWRAREGLEKMVAED----NER-------YRLVSDTITQKVEEIDAAILRSQQ 3786
S + E+V R+ ++K E+ +ER Y + +T++ ++++ + S++
Sbjct: 1517 SEV-EMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRK 1575
Query: 3787 FDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSG 3846
+ + W+ T+ +L + +++ K EI + K + + + G
Sbjct: 1576 MRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVG 1635
Query: 3847 HKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPW 3906
+ T ++E ++ KL + N+ + E L Q + F + + + W
Sbjct: 1636 EALKTVLGKKETL-VEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKW 1694
Query: 3907 LTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEG 3966
+ + +++ E E + QQ+E L+ L AE K++ T Q L G
Sbjct: 1695 IIQADTLLD-------ESEKKKPQQKED-VLKRLKAELNDIRPKVDSTRDQAANLMANRG 1746
Query: 3967 FS----IQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERL 4022
++ + + ++ I +K ++ + + QF+ I ++LE LE +++
Sbjct: 1747 DHCRKLVEPQISELNHRFAAISHRIKTGKASIP--LKELEQFNSDIQKLLEPLEAEIQQ- 1803
Query: 4023 RQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAV 4082
++ + E + ++E+ +V + L QRG+ + R K K
Sbjct: 1804 ----GVNLKEEDFNKDMNEDNEGTV---------KELLQRGDNLQQRITDERKREEIKIK 1850
Query: 4083 QDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPG 4142
Q L + L +R K L++ ++ L+ + D + + L +P
Sbjct: 1851 QQLLQTK---HNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPR 1907
Query: 4143 IDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAW 4202
D +K+ + +EE++ ++ + + L + A EP + + K E+ S +
Sbjct: 1908 -DERKIKEIDRELQKKKEELNAVRRQAE---GLSEDGAAMAVEPTQIQLSKRWREIESKF 1963
Query: 4203 DSLNKAWKDRIDKL-EEAMQAAVQ------------YQDGLQAVFDWVDIAGGKLASMSP 4249
+ +I + EE M + Y + V + L +
Sbjct: 1964 AQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDL 2023
Query: 4250 IGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELK 4309
D E + +Q E LK K Q ++ ++ + L+ T ++ +Q+ L +L
Sbjct: 2024 CAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPV-ERVKLQEALSQLD 2082
Query: 4310 LIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSE-QKPVGGDPKAIE 4368
W+ + + +RQ + + ++ +F + + WLT E L + Q P + +
Sbjct: 2083 FQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYK 2142
Query: 4369 IELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKT 4428
L + LQ+ + Q+ V +N G ++I+ S+ +AS LQ KL LN RWQ V ++
Sbjct: 2143 WYLKE---LQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQL 2199
Query: 4429 EQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLG-GLPETAKEQLNVHMEVC 4487
RK++L+ F ++ + WL + + +AS PL G + KE+L +
Sbjct: 2200 SDRKKRLEEQKNILSEFQRDLNEFVLWLEEADN--IASIPLEPGKEQQLKEKLEQVKLLV 2257
Query: 4488 AAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKE---KWESVETKLNERKTKL 4544
++ K L + G +L P S E D+ N LK+ +W V L E++ ++
Sbjct: 2258 EELPLRQGILKQLNETGGPVLVSAPISPEEQ-DKLENKLKQTNLQWIKVSRALPEKQGEI 2316
Query: 4545 EEALNLAMEFHNSLQDF-------INWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFAN 4597
E + + L+D + WL+ L + ++P+ F + E ++
Sbjct: 2317 EAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPN---QEGPFDVQETEI--- 2370
Query: 4598 EVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGR------ 4651
V + + + E+ G HL + +K +K L + S W K V RL++ R
Sbjct: 2371 AVQAKQPDVEEILSKGQHL--YKEKPATQPVKRKLEDLSSEW-KAVNRLLQELRAKQPDL 2427
Query: 4652 ------------------------------------SLDDARKRAKQFHEAWSKLMEWLE 4675
SL F+ AW++L +WL
Sbjct: 2428 APGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLS 2487
Query: 4676 ESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDN 4735
++ + S+ + D + I + + K + L + + ++LK KTS +
Sbjct: 2488 LLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEAR 2547
Query: 4736 LKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQ 4795
+ D + ++++WD + R+ +L E L S Q+ +A + L + +L +
Sbjct: 2548 TIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWK 2607
Query: 4796 PVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEG-SRDDSSWVKVQMQELS 4854
+D + I K K+L + ++V A +L+ S DD+ V + + ++
Sbjct: 2608 EGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENIN 2667
Query: 4855 TRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRT 4914
W ++ ++ LE R ++F + L WL EAE T VL D R
Sbjct: 2668 ASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTAN---VLQDATRKERL 2724
Query: 4915 LIDQH--KEFMKKLEEKRAELNKATTMGDTV--------LAICHPDSITTIKHWITIIRA 4964
L D KE MK+ ++ + E+ T + + ++ D ++ + +
Sbjct: 2725 LEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNF 2784
Query: 4965 RFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVK 5024
++ E+ + + L ++ L+ LL WLQ + L+ + I + V+
Sbjct: 2785 KWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAP--IGGDFPAVQ 2842
Query: 5025 ALIAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLY 5084
H+ F E+ K+P + +T + I + ++ G ++ LY
Sbjct: 2843 KQNDVHRAFKRELKTKEPVIMSTLETVR------------IFLTEQPLEGLEK-----LY 2885
Query: 5085 PSGSQTQIETKNPRVNLLVSK--------WQQVWLLALERRRKLNDALDRLEELRE 5132
+ E + V L+ K W+++ L + + +RK+++ L+RL+EL+E
Sbjct: 2886 QEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQE 2941
Score = 295 bits (755), Expect = 9e-79
Identities = 474/2585 (18%), Positives = 1053/2585 (40%), Gaps = 294/2585 (11%)
Query: 2574 LEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRK 2633
L ES NL ++QT ++ WL+ E + G +S D ++ Q + + + +
Sbjct: 334 LMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQ 393
Query: 2634 PQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKST 2693
+ + G ++ V+EQ+ + +W+ L ++ + + ++
Sbjct: 394 GRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQ 453
Query: 2694 QYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDA--MNQQLETAQKMKQEIQQEKKQIK--V 2749
+ L+ L+D L+ + + PD + +Q++ + ++++++QE+ ++
Sbjct: 454 NQK--LKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLT 511
Query: 2750 AQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMS 2809
+ D S+ ++ A L QL+ + + ++ + E+ LQ + +
Sbjct: 512 HMVVVVDESS---GDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQ 568
Query: 2810 RDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLL 2869
F AWL K++ NK H KD + +L
Sbjct: 569 CLFSAWLSEKEDAVNKIHTTG---------FKDQNEMLSSL------------------- 600
Query: 2870 KTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWID--- 2926
+ A L+ L KQ + LK+ L LK K + W+D
Sbjct: 601 ----QKLAVLKADLEK--------KKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFA 648
Query: 2927 KCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVV 2986
+C +NL + L+ + + S A + + Q + Q M + T + V +E+
Sbjct: 649 RCWDNLVQ---KLEKSTAQISQA-VTTTQPSLTQTTVMETVTTVTTREQILVKHAQEELP 704
Query: 2987 TDE---------NKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKE 3037
+ + +++D+ +LHS E + Q EF KE KE
Sbjct: 705 PPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQS-PEFAIFRKEG--NFSDLKE 761
Query: 3038 QLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLL 3097
+++ + ++ + LQ +S QAL VE ++G +
Sbjct: 762 KVNAIEREKAEKFRK-----LQDASRSAQAL---------------VEQMVNEG-----V 796
Query: 3098 QVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRD 3157
++I Q L+ + E C L +L + +QN I ++Q + + + +
Sbjct: 797 NADSIKQASEQLNSRWIEFCQLLSERLNWL-EYQNNIIAFYNQLQQLEQMTTTAENWLKI 855
Query: 3158 AETLQKQKETIKAFLK----KLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALS 3213
T + IK+ LK ++ L + +A +E + + D A +
Sbjct: 856 QPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFT 915
Query: 3214 KQCNKLLDRAQAREEQVEGTIKRLE--EFYSKLKEFSILLQKAEEHEESQGPVGMETETI 3271
++ QARE++++ L + + +Q++E + E +
Sbjct: 916 NHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIM 975
Query: 3272 NQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTS--TQGLEHDLDDVNARWKT 3329
Q+L + Q LQ +Q + +L + + + K+ S ++ + + +++ RWK
Sbjct: 976 EQRLGELQALQSS----LQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKK 1031
Query: 3330 LNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQ 3389
L+ ++ + +L+E + + Q+ +++L WM + + + + P + +++K Q+++
Sbjct: 1032 LSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQC 1091
Query: 3390 KLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQ 3449
+LL + + ++ + G+KI AEP ++ +L L+++W+ + + R
Sbjct: 1092 RLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEA 1151
Query: 3450 LEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHN 3509
L+G + L ++EW+T E+ + + +L++ + + K +++
Sbjct: 1152 LKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKE 1211
Query: 3510 KHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQA-LCNAKI 3568
+ S+ + ++ ++ +L+ Y + + + + + L++ C ++
Sbjct: 1212 AKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHEL 1271
Query: 3569 FGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSEL-RVLQEDILLRKQNVDQALLN 3627
E + WLNEV KL +TE + E+ VL L + + D N
Sbjct: 1272 LSYLE-KANKWLNEVEFKLK-------TTENIPGGAEEISEVLDSLENLMRHSEDNP--N 1321
Query: 3628 GLELLKQTTGDEVL---IIQDKLEAIKARYKDITKLSTDVAKTLEQALQLA----RRLHS 3680
+ +L QT D + +I ++LE +R++++ + + K LEQ++Q A + LH
Sbjct: 1322 QIRILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHL 1381
Query: 3681 THEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSAL 3740
E L T++DK +L +Y + +A+Q ++++ + +++ L+ + + +
Sbjct: 1382 IQESL-TFIDK---QLAAY---IADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHN--- 1431
Query: 3741 LELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQ---FDQAADAELSW 3797
+ +E ++++++ D +K++++ Q+ F+Q
Sbjct: 1432 ------QGKEAAQRVLSQ--------IDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMI 1477
Query: 3798 ITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEE 3857
+ E + L +L +EQ+ +QL + K ++ ++K+G +I+ E
Sbjct: 1478 LDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTEN 1537
Query: 3858 KQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQL 3917
+ + +++ + +Y+ + +ER QLE+ L + + L WL T +++
Sbjct: 1538 PKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKR 1597
Query: 3918 PAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAAD 3977
A L + + ++ I + K H+ + + G L + + +++K
Sbjct: 1598 SAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKL---- 1653
Query: 3978 TLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKE 4037
+L + V RA +E ++ ++ ++ ++++ I + + Q ++ E EK K
Sbjct: 1654 SLLNSNWIAVTSRA---EEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKP 1710
Query: 4038 QISEN--KNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWEN 4095
Q E+ K + ++ ++P ++ + + ++A G D K V+ ++ ++ +
Sbjct: 1711 QQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRG----DHCRKLVEPQISELNHRFAA 1766
Query: 4096 IHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAA 4155
I ++ +A + ++ E+F D L+ ++ +L++ + + + +
Sbjct: 1767 ISHRIKTGKASI--PLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTV 1824
Query: 4156 ETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDK 4215
+ + + D LQ+ + E + +K L + ++L R K
Sbjct: 1825 KELLQRGDNLQQRI-------------TDERKREEIKIKQQLLQTKHNALKDLRSQRRKK 1871
Query: 4216 LEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQ 4275
E QY+ + +D KLAS+ P D +K+ EL++ K
Sbjct: 1872 ALEISHQWYQYKRQADDLLKCLDDIEKKLASL-PEPRDERKIKEIDRELQKKKE------ 1924
Query: 4276 IEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIIN-------RQHKL-E 4327
E+ + QAE L +E+ V+ ++L W +E + + H + E
Sbjct: 1925 -ELNAVRRQAEGL----SEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVRE 1979
Query: 4328 GALLALG-----QFQHALDELLAWLTHTEGLLSEQKPVGGDP----KAIEIELAKHHVLQ 4378
++ + + + L +TH L E + + P K E + L+
Sbjct: 1980 ETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLK 2039
Query: 4379 N--DVLAHQS-TVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQL 4435
N D L S ++ ++ ++S+ E LQ L L+ +W+ V + + R+ +
Sbjct: 2040 NIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRF 2099
Query: 4436 DGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPET---AKEQLNVHMEVCAAFEA 4492
D ++ + + FH +I+ QWLT+ E+ L ++ +PE AK + + E+
Sbjct: 2100 DRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQ----IPENWEHAKYKWYL-KELQDGIGQ 2154
Query: 4493 KEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAM 4552
++ ++L G++++ + K+ + + + + +L +W+ V +L++RK +LEE N+
Sbjct: 2155 RQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILS 2214
Query: 4553 EFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKT 4612
EF L +F+ WL +A+ ++ P + ++++ K+ E+ + + +L++T
Sbjct: 2215 EFQRDLNEFVLWLEEADNIASIPLEPGK-EQQLKEKLEQVKLLVEELPLRQGILKQLNET 2273
Query: 4613 G----THLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERG-------RSLDDARKRAK 4661
G ++QD ++N L +W KV + L E+ + L K+ +
Sbjct: 2274 GGPVLVSAPISPEEQD--KLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLE 2331
Query: 4662 QFHEAWSKLMEWLEESEKSLDSELEIANDP------DKIKTQL---AQHKEFQKSLGAKH 4712
E + L+ WL + ++LEI N P D +T++ A+ + ++ L
Sbjct: 2332 DLEEQLNHLLLWL----SPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQ 2387
Query: 4713 SVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWD------TICGKS---------- 4756
+Y T ++ L+ + ++ +L ELR K T G S
Sbjct: 2388 HLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQ 2447
Query: 4757 -----------VERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVM 4805
+E + L + F A L DWL ++ + + + GD++ +
Sbjct: 2448 PVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDIN 2507
Query: 4806 NLIDNHKAFQKELGKRTSSVQALKRSARELIE--GSRDDSSWVKVQMQELSTRWETVCAL 4863
+I KA ++L +R ++ L +A+ L +++ + + +++ + +W+ V
Sbjct: 2508 EMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEH 2567
Query: 4864 SISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFM 4923
+++ +L L+ + ++ + L +A L P DA++ I + K+
Sbjct: 2568 LQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLA 2627
Query: 4924 KKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASA 4983
K L + + ++ A + +L D + H IT E + A + +R++
Sbjct: 2628 KDLRQWQTNVDVANDLALKLLRDYSADDTRKV-HMIT------ENINASWRSIHKRVSER 2680
Query: 4984 LAGLIAKQEL-------LEALLAWLQWAETT---LTDKD-KEVIPQEIEEVKALIAEHQT 5032
A L L LE LAWL AETT L D KE + ++ + VK L+ + Q
Sbjct: 2681 EAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQD 2740
Query: 5033 FMEEM 5037
E+
Sbjct: 2741 LQGEI 2745
Score = 277 bits (708), Expect = 2e-73
Identities = 491/2725 (18%), Positives = 1089/2725 (39%), Gaps = 258/2725 (9%)
Query: 2117 QDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVK 2176
Q L+E+L W+ + E +L+ QG++ + ++D + D+ Q + + +
Sbjct: 345 QTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNILQLGS 404
Query: 2177 KFMETTDPST--ASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQT 2234
K + T S + +Q +M L++R+ E + + + ++L ++L
Sbjct: 405 KLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLH--RVLMDLQNQKLKELND 462
Query: 2235 FLETKTQALT---EVDVPGKDVTELSQYMQESTSEFLEHK---KHLEVLHSLLKEISSHG 2288
+L TKT+ T E + G D+ +L + +Q+ HK + LE + ++
Sbjct: 463 WL-TKTEERTRKMEEEPLGPDLEDLKRQVQQ-------HKVLQEDLEQEQVRVNSLTHMV 514
Query: 2289 LPSDKALVLEKTNNLSKKFKEMEDT----IKEKKEAVTSCQEQLDAFQVLVKS---LKSW 2341
+ D++ T L ++ K + D + ++ Q+ L +Q L + +W
Sbjct: 515 VVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAW 574
Query: 2342 IKETTKKVPIVQPSFGAEDLGKSLEDTKKLQ--------------EKWSLKTPEIQKVNN 2387
+ E V + + G +D + L +KL + +SLK + + N
Sbjct: 575 LSEKEDAVNKIHTT-GFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKN 633
Query: 2388 SGIS------LCNLI----SAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSI 2437
++ L N + V K+ A + AV + + T T +T+
Sbjct: 634 KSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQ--AVTTTQPSLTQTTVMETVTTVTT- 690
Query: 2438 KKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTP 2497
++ + H E+L K ++ ++ + + + W+ + Q+P
Sbjct: 691 -REQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVL----QSP 745
Query: 2498 --APTDTEAVKTQVEQN-KSFEAELKQNVNKVQELKDKLTELLEENPDTP-EAPRWKQML 2553
A E + +++ + E E + K+Q+ L+E+ + A KQ
Sbjct: 746 EFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQAS 805
Query: 2554 TEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPN 2613
+++S+W E QL +R LE NN+ F QL+Q E + + +P
Sbjct: 806 EQLNSRWIEFCQLLSERLNWLEYQ-NNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPT 864
Query: 2614 MLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDS 2673
+ +Q + + + + +PQ E+L L G+ P + A T +
Sbjct: 865 AIKSQLKICKDEVNRLSGLQPQIERLKIQSIA-LKEKGQGPMF---LDADFVAFTNHFKQ 920
Query: 2674 LTGQLSDRCDWIDQAI--VKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLE 2731
+ + R + + +YQ + ++ + + KLS T + M Q+L
Sbjct: 921 VFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLG 980
Query: 2732 TAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENH 2791
Q ++ +Q+++ + +++S E + + + E I +K + + H
Sbjct: 981 ELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSE-ISRKYQSEFEEIEGRWKKLSSQLVEH 1039
Query: 2792 VQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLT 2851
Q L+ + Q + + W+ + P ++L+ +K + +
Sbjct: 1040 CQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQ 1099
Query: 2852 AQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKA 2911
G+ + + + + L+ +L + T WD +QV R+ LK LEK
Sbjct: 1100 TIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKT 1159
Query: 2912 LKYKEQVETLWPWIDKCQNNLEEIKF-CLDPAEGENSIAKLKSLQKEMDQHFGMVELLNN 2970
+ ++ + + W+ + + E F P E + ++ ++K ++E Q V+LL
Sbjct: 1160 VSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTE 1219
Query: 2971 TANSLLSVCE-IDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESK 3029
+ NS+++ + +E + E ++L + +L+ K LE + + E +++
Sbjct: 1220 SVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKAN 1279
Query: 3030 RQLQCAKEQLDIHDSL-GSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASD 3088
+ L + +L +++ G ++ L L+ + + +Q+ + LAQ L
Sbjct: 1280 KWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRI---LAQTLT----- 1331
Query: 3089 SKGTSDVLL--QVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDD 3146
G D L+ ++ET L ++ + LE +Q + ++ + D
Sbjct: 1332 DGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDK 1391
Query: 3147 ELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIK 3206
+L + DA + ++ + I++ L E ++ EE G +
Sbjct: 1392 QLAAYIADKVDAAQMPQEAQKIQSDLTSHE----------------ISLEEMKKHNQGKE 1435
Query: 3207 RDLEALSKQCNKLLDRAQAREEQVEGTIKRLEE---FYSKLKEFSILLQKAEEHEESQGP 3263
LS+ +D AQ + + V + ++ F +L+E ++L + + H +
Sbjct: 1436 AAQRVLSQ-----IDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALET 1490
Query: 3264 VGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDV 3323
+E E + QLN K + ++ + + V G+ ++Q ++ + + L+ + +
Sbjct: 1491 KSVEQEVVQSQLNHCVNLYKS-LSEVKSEVEMVIKTGRQIVQKK-QTENPKELDERVTAL 1548
Query: 3324 NARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVK 3383
+ L KV +R QL++ L + + + L W+ T+ + + +
Sbjct: 1549 KLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLD 1608
Query: 3384 AQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKA 3443
+++ K Q+ ++ +K ++ I GE + T + + + +LSLL+S W A+ ++A
Sbjct: 1609 SEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETL-VEDKLSLLNSNWIAVTSRA 1667
Query: 3444 ETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALED 3503
E L + F + ++ + +W+ + L E Q E+ + + KA +
Sbjct: 1668 EEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQK--EDVLKRLKAELN 1725
Query: 3504 DIINHNKHLHQAVSIGQSLKVLSSRED--KDMVQSKLD-----FSQVWY-IEIQEKSHSR 3555
DI Q+ ++++R D + +V+ ++ F+ + + I+ + S
Sbjct: 1726 DIRPKVDSTRD-----QAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPL 1780
Query: 3556 SELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQ------QSELRV 3609
EL Q K+ E E+ +N + +K +D EG K+ + R+
Sbjct: 1781 KELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNED--NEGTVKELLQRGDNLQQRI 1838
Query: 3610 LQE---DILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAK 3666
E + + KQ + Q N L+ L+ + L I + K + D+ K D+ K
Sbjct: 1839 TDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEK 1898
Query: 3667 TLEQALQLA--RRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQA-QMRPKELKKEA 3723
L + R++ EL K E+ + + + L + A+ A + +L K
Sbjct: 1899 KLASLPEPRDERKIKEIDRELQK--KKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRW 1956
Query: 3724 KNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNE-RYRLVSDTITQKVEEIDAAIL 3782
+ ++ ++ A + V RE ++ ED V T ++ + A+L
Sbjct: 1957 REIESKFAQFRRLNFAQIHTV----REETMMVMTEDMPLEISYVPSTYLTEITHVSQALL 2012
Query: 3783 RSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDL 3842
+Q A D + K+ SL +I+ Q+S ++ + + L+ ++ +
Sbjct: 2013 EVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERV 2072
Query: 3843 VKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEE 3902
K+ A S+ + Q +K++K+ K+ + E++ + + NQ
Sbjct: 2073 -----KLQEALSQLDFQW--EKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQ------- 2118
Query: 3903 LWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELS 3962
WLTE + + + P E + + ++L++ I + + + +N TG ++++ S
Sbjct: 2119 ---WLTEAEQFLRKTQIP--ENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQS 2173
Query: 3963 PGEGFSI-QEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVER 4021
SI QEK + + + ++ + + R L+E + ++F +++ + LE +
Sbjct: 2174 SKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEE-ADN 2232
Query: 4022 LRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKA 4081
+ P + +++KE++ + K + ++ Q + + L + G ++ + + ++
Sbjct: 2233 IASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEE--QDK 2290
Query: 4082 VQDKLDQMVFIWENIHTLVEER----EAKLLDVMELAEKF-----WCDHMSLIVTIKDTQ 4132
+++KL Q W + + E+ EA++ D+ +L +K +H L++ + +
Sbjct: 2291 LENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNH--LLLWLSPIR 2348
Query: 4133 DFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVK 4192
+ + P + Q+ E A + Q +++ +++ G L +P VK
Sbjct: 2349 NQLEIYNQPNQEGPFDVQETEIA------VQAKQPDVEEILSKGQHLYKE--KPATQPVK 2400
Query: 4193 KSIDELNSAWDSLNKAWKD-----------------------------------RIDKLE 4217
+ +++L+S W ++N+ ++ I KLE
Sbjct: 2401 RKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLE 2460
Query: 4218 EA------MQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEA 4271
+ A + + DW+ + + S + DLE + + I + K +
Sbjct: 2461 MPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDL 2520
Query: 4272 YQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALL 4331
Q++ ++E L A+ L K + + + + D + ++ WD ++E + NR+ +L L
Sbjct: 2521 EQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLK 2580
Query: 4332 ALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAV 4391
Q+ A +E L L K AI+ ++ + L D+ Q+ V+
Sbjct: 2581 DSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVA 2640
Query: 4392 NKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIED 4451
N L+ + ++ + E +N W+++ ++ +R+ L+ R + F ++E
Sbjct: 2641 NDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEK 2700
Query: 4452 LQQWLTDTE------RHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQ 4505
WLT+ E + + L + KE + ++ EA + Y +L + Q
Sbjct: 2701 FLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQ 2760
Query: 4506 QMLARCPKSAE-TNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINW 4564
++L S + + + ++N+ KW + K ++ LE + + H SLQ+ + W
Sbjct: 2761 KILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVW 2820
Query: 4565 LTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQD 4624
L + L+ + V Q D H+ F E+ + I+ +T ++ F +Q
Sbjct: 2821 LQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLET---VRIFLTEQP 2877
Query: 4625 VVLIKNLL-----ISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKL----MEWLE 4675
+ ++ L + + R + V + L RK+A++ + W KL +W
Sbjct: 2878 LEGLEKLYQEPRELPPEERAQNVTRLL----------RKQAEEVNTEWEKLNLHSADWQR 2927
Query: 4676 ESEKSLDSELEIANDPDKIKTQLAQ 4700
+ +++L+ E+ D++ +L Q
Sbjct: 2928 KIDETLERLQELQEATDELDLKLRQ 2952
Score = 226 bits (576), Expect = 5e-58
Identities = 345/1758 (19%), Positives = 713/1758 (40%), Gaps = 172/1758 (9%)
Query: 3339 AQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDD 3398
+ L E+ ++ R+Q ALE +LSW++ E+ + Q S + +VVK Q + L
Sbjct: 332 SSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTA 391
Query: 3399 RKSTVEVIKREGEKIATTAEPA--DKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVV 3456
+ V I + G K+ T + + ++ ++ +Q++LL+SRWE L + + L + +
Sbjct: 392 HQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMD 451
Query: 3457 AQQFHETLEPLNEWLTTIEKRL--VNCEPIGTQASKLEEQIAQHKALEDDI----INHNK 3510
Q ++ L+ LN+WLT E+R + EP+G L+ Q+ QHK L++D+ + N
Sbjct: 452 LQ--NQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNS 509
Query: 3511 HLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFG 3570
H V + +S S ++ +L + I + R LLQ L +
Sbjct: 510 LTHMVVVVDES----SGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLT 565
Query: 3571 EDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLE 3630
E++ WL+E D ++K+ T G Q L LQ+ +L+ LE
Sbjct: 566 EEQCLFSAWLSEKEDAVNKI-----HTTGFKDQNEMLSSLQKLAVLKAD---------LE 611
Query: 3631 LLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLD 3690
KQ+ G + QD L +K + S ++ WLD
Sbjct: 612 KKKQSMGKLYSLKQDLLSTLKNK--------------------------SVTQKTEAWLD 645
Query: 3691 KVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRARE 3750
++ V K E+++ + + + +++++ V++ LV A+E
Sbjct: 646 NF---ARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTREQILVK-HAQE 701
Query: 3751 GLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGD 3810
L ++ ++ D+ +K ++D L SWIT +E L S
Sbjct: 702 ELPP--PPPQKKRQITVDSEIRKRLDVDITELH------------SWITRSEAVLQSPEF 747
Query: 3811 IRLEQDQTSAQLQVQKTFTMEILRHKDI--IDDLVKSGHKIMTACSEE--EKQSMKKKLD 3866
++ + L+ +K +E + + + D +S ++ E S+K+ +
Sbjct: 748 AIFRKEGNFSDLK-EKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASE 806
Query: 3867 KVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYET 3926
++ + CQ+ SER LE +++ F+ ++L T ++ + P E
Sbjct: 807 QLNSRWIEFCQLLSERLNWLEYQNNII-AFYNQLQQLEQMTTTAENWLKIQPTTPSEPTA 865
Query: 3927 LRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKED 3986
++ Q + + ++ +P I+++ L E G F + +VA + Q+ D
Sbjct: 866 IKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMF-LDADFVAFTNHFKQVFSD 924
Query: 3987 VKKRAVALDEAIS--QSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKN 4044
V+ R L ++ + + I +++ +L P + E +++++ E +
Sbjct: 925 VQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQA 984
Query: 4045 VSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEERE 4104
+ +++ Q L +EM S +IS K Q + +++ W+ + + + E
Sbjct: 985 LQSSLQEQQSGLYYLSTTVKEM---SKKAPSEISRK-YQSEFEEIEGRWKKLSSQLVEHC 1040
Query: 4105 AKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGI-DPSVVKQQQEAAETIREEID 4163
KL + M K +L + + F+++ E P + D ++K+Q + + +I
Sbjct: 1041 QKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKE-EWPALGDSEILKKQLKQCRLLVSDIQ 1099
Query: 4164 GLQEELDIVINLGSELIAACGEPD-KPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQA 4222
+Q L+ V N G + I EP+ ++ + ELN+ WD + + R + L+ ++
Sbjct: 1100 TIQPSLNSV-NEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEK 1158
Query: 4223 AVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLN 4282
V Q L + +W+ A + + +++ +EE+K+ K EA Q++ +++ L
Sbjct: 1159 TVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLT 1218
Query: 4283 HQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDE 4342
++ + + + ++ L L + L R+ + LE + L++
Sbjct: 1219 ESVNSVIAQAPPVA-QEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEK 1277
Query: 4343 LLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESS 4402
WL E L + + G + I L L+N + + + L +
Sbjct: 1278 ANKWLNEVEFKLKTTENIPGGAEEISEVLDS---LENLMRHSEDNPNQIRILAQTLTDGG 1334
Query: 4403 AGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERH 4462
+E N +LE N RW+ + E+ +R++ L+ +++ A+ + +Q+ LT ++
Sbjct: 1335 VMDELIN--EELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQ 1392
Query: 4463 LLA----SKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETN 4518
L A +P+ A++ + ++ + + EE M+K Q K A
Sbjct: 1393 LAAYIADKVDAAQMPQEAQK---IQSDLTSHEISLEE-----MKKHNQ-----GKEAAQR 1439
Query: 4519 IDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRP 4578
+ I+ ++K + V K F LQ+ L + + L
Sbjct: 1440 VLSQIDVAQKKLQDVSMKF--------RLFQKPANFEQRLQESKMILDEVKMHLPALETK 1491
Query: 4579 SLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSR 4638
S+ + V Q++ ++ + ++ + KTG + Q ++ + + +++
Sbjct: 1492 SVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLH 1551
Query: 4639 WEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQL 4698
+ ++ ++ ER + L+ K +++ + + L EWL ++ L + P + +++
Sbjct: 1552 YNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEV 1611
Query: 4699 AQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVE 4758
A K QK + + + G +L KT L ++D LS L W + ++ E
Sbjct: 1612 AWGKATQKEIEKQKVHLKSITEVGEAL--KTVLGKKETLVEDKLSLLNSNWIAVTSRAEE 1669
Query: 4759 RQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKEL 4818
N L E F + + W+ + + L E + D K + EL
Sbjct: 1670 WLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEK-----KKPQQKEDVLKRLKAEL 1724
Query: 4819 GKRTSSVQALKRSARELIEGSRDD-SSWVKVQMQELSTRWETVCALSISKQTRLEAALRQ 4877
V + + A L+ D V+ Q+ EL+ R+ + K + L++
Sbjct: 1725 NDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAIS--HRIKTGKASIPLKE 1782
Query: 4878 AEEFHSVVHALLEWL-AEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKA 4936
E+F+S + LLE L AE +Q GV +ED + + + ++ +K+L ++ L +
Sbjct: 1783 LEQFNSDIQKLLEPLEAEIQQ-----GVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQR 1837
Query: 4937 TTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIA--KQELL 4994
T R E + +Q Q +AL L + +++ L
Sbjct: 1838 IT------------------------DERKREEIKIKQQLLQTKHNALKDLRSQRRKKAL 1873
Query: 4995 EALLAWLQWAETT------LTDKDKEVI----PQEIEEVKALIAEHQTFMEEMTRKQPDV 5044
E W Q+ L D +K++ P++ ++K + E Q EE+ +
Sbjct: 1874 EISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQA 1933
Query: 5045 DKVTKTYKRRAADPSSLQ 5062
+ +++ A +P+ +Q
Sbjct: 1934 EGLSEDGAAMAVEPTQIQ 1951
Score = 219 bits (557), Expect = 8e-56
Identities = 111/230 (48%), Positives = 152/230 (66%), Gaps = 5/230 (2%)
Query: 72 ERDKVQKKTFTKWINQHLMKVRK-HVNDLYEDLRDGHNLISLLEVLSGDTLPREKGRMRF 130
ER+ VQKKTFTKW+N K K H+ +L+ DL+DG L+ LLE L+G LP+EKG R
Sbjct: 12 EREDVQKKTFTKWVNAQFSKFGKQHIENLFSDLQDGRRLLDLLEGLTGQKLPKEKGSTRV 71
Query: 131 HRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDI--HVTGES 188
H L NV AL L+ V LVNI + DI DGN KLTLGLIW IILH+Q+ ++ ++
Sbjct: 72 HALNNVNKALRVLQNNNVDLVNIGSTDIVDGNHKLTLGLIWNIILHWQVKNVMKNIMAGL 131
Query: 189 EDMSAKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAV-QS 247
+ ++++ LL W +Q+T Y + NFTT W DG NA+IH +RPDL D N+V QS
Sbjct: 132 QQTNSEKILLSWVRQSTRNYPQVNVINFTTSWSDGLALNALIHSHRPDLFDWNSVVCQQS 191
Query: 248 NLANLEHAFYVAE-KIGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAFPK 296
LEHAF +A ++G+ +LLDPEDVD + PD+KS++ Y++SL+ P+
Sbjct: 192 ATQRLEHAFNIARYQLGIEKLLDPEDVDTTYPDKKSILMYITSLFQVLPQ 241
Score = 205 bits (521), Expect = 1e-51
Identities = 284/1564 (18%), Positives = 642/1564 (41%), Gaps = 148/1564 (9%)
Query: 3506 INHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCN 3565
++H H Q +++ + + K +S ++Q Y+ + + S
Sbjct: 268 LHHQMHYSQQITVSLAQGYERTSSPKPRFKSYA-YTQAAYVTTSDPTRSPFPSQHLEAPE 326
Query: 3566 AKIFG----EDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQE--------- 3612
K FG E EV L + + + LS L + + + + +++ V+++
Sbjct: 327 DKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYM 386
Query: 3613 -DILLRKQNVDQALLNGLELLK--QTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLE 3669
D+ + V L G +L+ + + DE +Q+++ + +R++ + S + L
Sbjct: 387 MDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLH 446
Query: 3670 QALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKG--EEASQAQMRPKELKKEAKNNK 3727
+ L + + +EL WL K E E + L E+ + + K L+++ + +
Sbjct: 447 RVLMDLQ--NQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQ 504
Query: 3728 ALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQF 3787
++SL + + E A LE+ + +R+ + + + +L+ Q+
Sbjct: 505 VRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRL 564
Query: 3788 DQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGH 3847
+ +W++E E V K T +++ L K
Sbjct: 565 TEEQCLFSAWLSEKEDA-------------------VNKIHTTGFKDQNEMLSSLQKLA- 604
Query: 3848 KIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWL 3907
++ A E++KQSM K LK D + + ++ Q + ++ ++ F ++ L L
Sbjct: 605 -VLKADLEKKKQSMGKLYS--LKQ-DLLSTLKNKSVTQ--KTEAWLDNFARCWDNLVQKL 658
Query: 3908 TETQSIISQLPA---PALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPG 3964
++ + ISQ P+L T+ + +++ +H +++ PQ
Sbjct: 659 EKSTAQISQAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQ--EELPPPPPQ------- 709
Query: 3965 EGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQ 4024
+++ + D+ +++KR LD I++ + + + +L+S E + R
Sbjct: 710 -----KKRQITVDS-------EIRKR---LDVDITELHSWITRSEAVLQSPEFAIFRKE- 753
Query: 4025 PPSISAEVEKIKEQISENKNVSVD-MEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQ 4083
+KE+++ + + KLQ + + E+M+ ++ ++A +++
Sbjct: 754 -----GNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMV------NEGVNADSIK 802
Query: 4084 DKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGI 4143
+Q+ W L+ ER L+ F+ L +++++
Sbjct: 803 QASEQLNSRWIEFCQLLSER-LNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPS 861
Query: 4144 DPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWD 4203
+P+ +K Q + + + GLQ +++ L + IA + P+ +D A+
Sbjct: 862 EPTAIKSQLKICKDEVNRLSGLQPQIE---RLKIQSIALKEKGQGPMF---LDADFVAFT 915
Query: 4204 SLNKAWKDRIDKLEEAMQAA------VQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETV 4257
+ K + E+ +Q ++YQ+ + A+ WV + KL+ TD E +
Sbjct: 916 NHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIM 975
Query: 4258 KQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEE 4317
+Q++ EL+ +S +QQ + L+ + + KK E + Q E++ W L
Sbjct: 976 EQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRK-YQSEFEEIEGRWKKLSS 1034
Query: 4318 RIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVL 4377
+++ KLE + L + Q+ + L W+ + L E+ P GD + ++ +L + +L
Sbjct: 1035 QLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLL 1094
Query: 4378 QNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDG 4437
+D+ Q ++ +VN+ G + + E AS L+ +L+ LN +W ++ ++ RK+ L G
Sbjct: 1095 VSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKG 1154
Query: 4438 ALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETY 4497
L + ++ ++ +W+T E L P+ ++ + + KE
Sbjct: 1155 GLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKV 1214
Query: 4498 KSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNS 4557
K L + ++A+ P A+ + +++ L ++ + T+LN + LEE E +
Sbjct: 1215 KLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSY 1274
Query: 4558 LQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLK 4617
L+ WL + E L + + +D + + QI L +T T
Sbjct: 1275 LEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTDGG 1334
Query: 4618 YFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEES 4677
+ LI L + SRW ++ + V R + L+ + + A++ ++ + E L
Sbjct: 1335 VMDE-----LINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFI 1389
Query: 4678 EKSLDSEL-------EIANDPDKIKTQLAQH----KEFQKSLGAKHSVYDTTNRTGRSLK 4726
+K L + + ++ + KI++ L H +E +K K + ++ + K
Sbjct: 1390 DKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQK 1449
Query: 4727 EKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYR 4786
KL D+ + R + K + +L+E+ + + L AL
Sbjct: 1450 ----------KLQDVSMKFR-----LFQKPANFEQRLQESKMILDEVKMHLPAL------ 1488
Query: 4787 VEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSR-DDSSW 4845
E + E + V ++ +NL K L + S V+ + ++ R++++ + ++
Sbjct: 1489 -ETKSVEQEVVQSQLNHCVNL-------YKSLSEVKSEVEMVIKTGRQIVQKKQTENPKE 1540
Query: 4846 VKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVL 4905
+ ++ L + + A ++ +LE L+ + + ++ L EWLA + L +
Sbjct: 1541 LDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAV 1600
Query: 4906 PDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRAR 4965
L + + K K++E+++ L T +G+ + + T ++ ++++ +
Sbjct: 1601 EGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKE-TLVEDKLSLLNSN 1659
Query: 4966 FEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKA 5025
+ V + A++ L + + ++ + W+ A+T L + +K+ Q+ + +K
Sbjct: 1660 WIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKR 1719
Query: 5026 LIAE 5029
L AE
Sbjct: 1720 LKAE 1723
Score = 184 bits (467), Expect = 2e-45
Identities = 494/2698 (18%), Positives = 1056/2698 (39%), Gaps = 384/2698 (14%)
Query: 1210 KLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVF 1269
KLK +N L T+ T+ EEE + D +++ + K + ++++++
Sbjct: 456 KLKELNDWLTKTEE--------RTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRV 507
Query: 1270 HALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIG 1329
++L + + DE + L+ E+ L +RW N+ ++R L+ I
Sbjct: 508 NSLTHMV----VVVDESSGDHATAALE-----EQLKVLGDRWANICRWTEDRWVLLQDI- 557
Query: 1330 KSLKYYRDTYHP--LDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSK 1387
LK+ R T W+ + E KI ++ + + L + +L +++E K+
Sbjct: 558 -LLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQS 616
Query: 1388 MDECQKYAEQYSATVKDYELQTMT------YRAMVDSQQKSPVKRRRMQSSADLIIQEFM 1441
M + + +T+K+ + T + D+ + K S A Q +
Sbjct: 617 MGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSL 676
Query: 1442 DLRTRYTALVTLMTQ---YIKFAGDSLKRLEEEEK---SLEEEKKEHVE-KAKELQKWVS 1494
T + T+ T+ +K A + L ++K +++ E ++ ++ EL W++
Sbjct: 677 TQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWIT 736
Query: 1495 NISKTLKDAE-----KAGKPPFSKQKISS--EEISTKKEQLSEALQTIQLFLAKHGD--- 1544
L+ E K G K+K+++ E + K +L +A ++ Q + + +
Sbjct: 737 RSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGV 796
Query: 1545 -----KMTDEERNE--------LEKQVKTLQESYNLL-FSESLKQLQESQTSGD--VKV- 1587
K E+ N L +++ L+ N++ F L+QL++ T+ + +K+
Sbjct: 797 NADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQ 856
Query: 1588 -----EEKIVAERQQEYKEKLQGICDLLTQTENRLI--------GHQEAFMIGDGTVELK 1634
E + + + K+++ + L Q E I G F+ D
Sbjct: 857 PTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTN 916
Query: 1635 KY-------QSKQEELQKDM--------QGSAQALAEVVKNTENFLKENGEKLSQEDKAL 1679
+ Q++++ELQ Q + A+ V+ +E K + +LS D +
Sbjct: 917 HFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSET--KLSIPQLSVTDYEI 974
Query: 1680 IEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDW 1739
+EQ+L E ++ Q +L+ +QS ++T +KE ++K + E K ++ +
Sbjct: 975 MEQRLGE--LQALQSSLQEQQSGLYY---LSTTVKEMSKKAPS-----EISRKYQSEFEE 1024
Query: 1740 LSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQEN 1799
+ K +H Q +E+ Q + + + E DV +
Sbjct: 1025 IEGRWKKLSSQLVEHCQKLEE-----QMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALG 1079
Query: 1800 LNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYE 1859
++ +K Q ++S Q + + S +K PE +L+ +KEL ++
Sbjct: 1080 DSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWD 1139
Query: 1860 TALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKR 1919
+ + + E+ D +E W+ Q+E+E + + L ++
Sbjct: 1140 HMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEE 1199
Query: 1920 QKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRF 1979
K E+ + ++ +T S N V+ A ++ ++++L+ T +
Sbjct: 1200 MKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQ------------EALKKELETLTTNY 1247
Query: 1980 RSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQ 2039
+ L C L K L + + + + LL+ L+ A+K L+E ++ +
Sbjct: 1248 QWL---CTRLNGKCKTLEEVWACWHE----LLSYLE----KANKWLNE--------VEFK 1288
Query: 2040 LEETKALQG---QISSQQVAVEKLKKTAEVLLDARGSLLPAKND-------IQKTLDDIV 2089
L+ T+ + G +IS ++E L + +E + L D I + L+
Sbjct: 1289 LKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTDGGVMDELINEELETFN 1348
Query: 2090 GRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLK-------EQGQVPL 2142
R+ +L + R + L+ ++ + + L + + + ++ L + Q+P
Sbjct: 1349 SRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQ 1408
Query: 2143 NSTALQ-DIISKNIMLEQ---DIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLS 2198
+ +Q D+ S I LE+ G++++ +++ + D S L K +
Sbjct: 1409 EAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFE 1468
Query: 2199 ARFSEASHKHKETLAKMEELKTK--------------VELFENLSE---KLQTFLETKTQ 2241
R E+ E + L+TK V L+++LSE +++ ++T Q
Sbjct: 1469 QRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQ 1528
Query: 2242 ALTEVDVP-------------------GKDVTELSQYMQESTSEFLEHKKHLEVL----- 2277
+ + G VTE Q +++ + +K + VL
Sbjct: 1529 IVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLA 1588
Query: 2278 ---HSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVL 2334
L K + G+PS+ + K+ ++ + +K E + + L + L
Sbjct: 1589 ATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETL 1648
Query: 2335 VKSLKS-----WIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSG 2389
V+ S WI T++ AE+ L + +K E + I K
Sbjct: 1649 VEDKLSLLNSNWIAVTSR----------AEEWLNLLLEYQKHMETFDQNVDHITKWIIQA 1698
Query: 2390 ISLCNLISAVTTPAKAIAAVKSGGAVLNG-----EGTATNTEEFWANKGLTSIKKDMTDI 2444
+L + S P + +K A LN + T AN+G
Sbjct: 1699 DTLLD-ESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRG----------- 1746
Query: 2445 SHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEA 2504
+ L++ +I+ELN + + + + A + L+++ + + Q+ P + E
Sbjct: 1747 ----DHCRKLVEPQISELNHRFAAISHRIKTGKASIP-LKELEQFNSDIQKLLEPLEAEI 1801
Query: 2505 VKTQVEQNKSFEAELKQ-NVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQEL 2563
+ + + F ++ + N V+EL + L + D + K + +K L
Sbjct: 1802 QQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNAL 1861
Query: 2564 NQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQ 2623
L R++K E S+ Q++ L + L + E ++ L P D + +++Q
Sbjct: 1862 KDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASL-PEPRDERKIKEIDRELQ 1920
Query: 2624 ILLQEFATRKPQYEQLTAAGQGILSRP-------------GEDPSLRGIVKEQLAAVTQK 2670
+E + Q E L+ G + P + R + Q+ V ++
Sbjct: 1921 KKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREE 1980
Query: 2671 WDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQL 2730
T + ++ + V ST Y + + +S L +++ L++ + + + +Q
Sbjct: 1981 ----TMMVMTEDMPLEISYVPST-YLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQE 2035
Query: 2731 ETAQKMKQEIQQEKKQIKVAQALCEDLSAL--------VKEEYLKAELSRQLEGILKSFK 2782
E+ + +K +QQ +I + + + +AL VK + ++L Q E + K +K
Sbjct: 2036 ESLKNIKDSLQQSSGRIDIIHS--KKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYK 2093
Query: 2783 DVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSH-PISAKLDVLESLIK 2841
D + + + V+ + F Q + + +L + +N H L L+ I
Sbjct: 2094 DRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKELQDGIG 2153
Query: 2842 DHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERE 2901
+ +TL A GE ++ ++ ++ + LQ +L ++ W KQ+ +R+
Sbjct: 2154 QRQTVVRTLN----------ATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRK 2203
Query: 2902 NKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGE---NSIAKLKSLQKEM 2958
+L+E +++ + W+++ +N+ I L+P + + + ++K L +E+
Sbjct: 2204 KRLEEQKNILSEFQRDLNEFVLWLEEA-DNIASIP--LEPGKEQQLKEKLEQVKLLVEEL 2260
Query: 2959 DQHFGMVELLNNTANSLLSVCEIDKEVVTD-ENK-------------------------- 2991
G+++ LN T +L I E ENK
Sbjct: 2261 PLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQI 2320
Query: 2992 ----SLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKE-----SKRQLQCAKEQLDIH 3042
L +K++ + EQL+ L + + + + + ++E + ++ +Q D+
Sbjct: 2321 KDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVE 2380
Query: 3043 DSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASD---------SKGTS 3093
+ L + K Q ++ L+ L + RL Q+L + D + T
Sbjct: 2381 EILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQ 2440
Query: 3094 DVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAP 3153
V L + + + + +S+ E S L ++ + F E+ + D + S
Sbjct: 2441 TVTLVTQPVVTKETAISKL--EMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRV 2498
Query: 3154 VGRDAETLQ----KQKETIKAFLKK---LEALMASNDN-ANKTCKMMLATEETSPDLVGI 3205
+ D E + KQK T++ ++ LE L+ + N NKT T T
Sbjct: 2499 MVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITD------ 2552
Query: 3206 KRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVG 3265
+E + Q +++ + Q R +Q+ +K ++ +E +L +A ES
Sbjct: 2553 --RIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGP 2610
Query: 3266 METETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNA 3325
+ I +++ K K ++ Q N L L++ + + T+ + +++NA
Sbjct: 2611 YTVDAIQKKITETKQLAK-DLRQWQTNVDVANDLALKLLRDYS-ADDTRKVHMITENINA 2668
Query: 3326 RWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELV-----ANQKPPSAE-F 3379
W++++K+V++R A L+E +F LE L+W+ + E A +K E
Sbjct: 2669 SWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDS 2728
Query: 3380 KVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKIL-KQLSLLDSRWEA 3438
K VK +++ + LQ ++ + +KI + E +D +L ++L ++ +W
Sbjct: 2729 KGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSE 2788
Query: 3439 LLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQH 3498
L K+ LE S ++ H +L+ L WL + L PIG +++Q H
Sbjct: 2789 LRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVH 2848
Query: 3499 KALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSEL 3558
+A + ++ + +S +++++ + + + ++ + + + +E++ + + L
Sbjct: 2849 RAFKRELKTKEPVI---MSTLETVRIFLTEQPLEGLEKL--YQEPRELPPEERAQNVTRL 2903
Query: 3559 LQQALCNAKIFGED-EVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLR 3617
L++ E + +W ++ + L +L +T+ L +L++ Q +++
Sbjct: 2904 LRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDEL-----DLKLRQAEVIKG 2958
Query: 3618 K-QNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQL 3674
Q V L++ L QD LE +KA +I L +V+ + A QL
Sbjct: 2959 SWQPVGDLLIDSL--------------QDHLEKVKALRGEIAPLKENVSHVNDLARQL 3002
Score = 38.9 bits (89), Expect = 0.14
Identities = 46/168 (27%), Positives = 73/168 (43%), Gaps = 27/168 (16%)
Query: 648 VQDLLNWVDEMQVQLDR-TEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMT 706
+Q+LL W+ +L R G D P+V+ +VHRA + E KE I T
Sbjct: 2814 LQELLVWLQLKDDELSRQAPIGGDFPAVQKQ----NDVHRAFKR-ELKTKEPVIMSTLET 2868
Query: 707 APLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYD 766
+ LT + L LE Y + R L RA N + L K+ EEV +
Sbjct: 2869 VRIFLT-EQPLEGLEKLY--------QEPRELPP----EERAQN-VTRLLRKQAEEVNTE 2914
Query: 767 WSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARL 814
W + N + A+ R++D+ E ++ +QE ++L L+ A +
Sbjct: 2915 WEKLNL-------HSADWQRKIDETLERLQELQEATDELDLKLRQAEV 2955
>gi|23097308 spectrin repeat containing, nuclear envelope 1 isoform 2
[Homo sapiens]
Length = 8749
Score = 318 bits (815), Expect = 9e-86
Identities = 749/4090 (18%), Positives = 1600/4090 (39%), Gaps = 532/4090 (13%)
Query: 1228 VKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMF 1287
++ +E L + V ++N+++ + K +R + + KR+ L L + +S
Sbjct: 334 IEQFERDLTRAQMV---ESNLQDKYQSFKHFRVQYEMKRKQIEHLIQPLHRDGKLS---- 386
Query: 1288 KTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQ 1347
LD K+ D++ R + H+Q+D L G + Y + + +Q
Sbjct: 387 -------LDQALVKQSWDRVTSRLFDWHIQLDKSLPAPLGTIGAWLYRAEVALREEITVQ 439
Query: 1348 QVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQS------KMDECQKYAEQYSAT 1401
QV + + E K L + K EI +S D+ + AE++
Sbjct: 440 QVHEETANTIQRKLEQHKDLLQNTDAHKRAFHEIYRTRSVNGIPVPPDQLEDMAERFHFV 499
Query: 1402 VKDYELQTMT-------YR-----AMVDSQQKSPVKRRRMQSSADLIIQEFMDL------ 1443
EL M YR + +S+ KS + + + S + ++Q ++
Sbjct: 500 SSTSELHLMKMEFLELKYRLLSLLVLAESKLKSWIIKYGRRESVEQLLQNYVSFIENSKF 559
Query: 1444 ----RTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKT 1499
Y L Y+K G S++ E K + E + + E++ S + +
Sbjct: 560 FEQYEVTYQILKQTAEMYVKADG-SVEEAENVMKFMNETTAQWRNLSVEVRSVRSMLEEV 618
Query: 1500 LKDAEKAGKPPFSKQ-------KISSEEISTKKE---------QLSEALQTIQLFLAKHG 1543
+ + ++ G S Q K+ ++ + KK+ Q A+ FL +
Sbjct: 619 ISNWDRYGNTVASLQAWLEDAEKMLNQSENAKKDFFRNLPHWIQQHTAMNDAGNFLIETC 678
Query: 1544 DKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVE--------EKIVAER 1595
D+M + L++Q+ L + LF E +KQ ++ +K E E
Sbjct: 679 DEMVSRD---LKQQLLLLNGRWRELFME-VKQYAQADEMDRMKKEYTDCVVTLSAFATEA 734
Query: 1596 QQEYKEKLQG-------ICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQ 1648
++ E L+ + L E R+ + I T L +S QEE K+M
Sbjct: 735 HKKLSEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLITKESPQEE-GKEMF 793
Query: 1649 GSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKV 1708
+ L E + +KE L E + L+ I E+L + L K+
Sbjct: 794 ATMSKLKEQLTK----VKECYSPLLYESQQLL--------IPLEELEKQMTSFYDSLGKI 841
Query: 1709 --VTTAIKEETEKVAAVKQLEESKTKI-ENLLDWLSNVDKDSERAGTKHKQVIEQNGT-H 1764
+ T ++ E + A KQ + EN L+ ++K S+ K V N H
Sbjct: 842 NEIITVLEREAQSSALFKQKHQELLACQENCKKTLTLIEKGSQSV---QKFVTLSNVLKH 898
Query: 1765 FQEGDGKSAIGEEDEVNGNLLETDVDGQVGT-TQENLNQQYQKVKAQHEKIISQHQAVII 1823
F + + I + ++++ D + T L +++++ +A+ EK++ Q +
Sbjct: 899 FDQTRLQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMKKFEESRAELEKVLRIAQEGLE 958
Query: 1824 ATQSAQVLLEKQGQYLSPEEKEKLQKNMKE-------LKVHYETALAESEKKM-KLTHSL 1875
+ LL + ++ S ++ L +K L + L E+ +K+ K L
Sbjct: 959 EKGDPEELLRRHTEFFSQLDQRVLNAFLKACDELTDILPEQEQQGLQEAVRKLHKQWKDL 1018
Query: 1876 QEELE------KFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVIS 1929
Q E K D + F +++ EL+ E G +K + F D
Sbjct: 1019 QGEAPYHLLHLKIDVEKNRFLASVEECRTELDR-ETKLMPQEGSEKIIKEHRVFFSDKGP 1077
Query: 1930 HKGDLRYITISGNRVLEAAKSCSK---RDGGKVDTSATHREVQRKLDHATDRFRSLYSKC 1986
H + R+ + C K RD + DT T ++L A D S Y K
Sbjct: 1078 HH-------LCEKRLQLIEELCVKLPVRDPVR-DTPGTCHVTLKELRAAID---STYRKL 1126
Query: 1987 NVLGNNLKDLVDKYQHYED---ASCGLLAGLQACEATASKHLSEPIAVDP--KNLQRQLE 2041
+ KD ++ + + L G++ + H AV+ + ++ E
Sbjct: 1127 MEDPDKWKDYTSRFSEFSSWISTNETQLKGIKGEAIDTANHGEVKRAVEEIRNGVTKRGE 1186
Query: 2042 ETKALQG------QISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVG--RYE 2093
L+ ++SS+ A ++ + A+ L + +L+ ++++K L + +Y+
Sbjct: 1187 TLSWLKSRLKVLTEVSSENEAQKQGDELAK-LSSSFKALVTLLSEVEKMLSNFGDCVQYK 1245
Query: 2094 DLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISK 2153
++ K+ L+ ++ S VQ+ +++LD E+ + Q + + + I +K
Sbjct: 1246 EIVKN------SLEELISGSKEVQEQAEKILD----TENLFEAQQLLLHHQQKTKRISAK 1295
Query: 2154 NIMLEQDIAGRQSSINAM----NEKVKKFMETTDPSTAS-SLQAKMKDLSARFSEASHKH 2208
++Q IA Q + +E+++K T D S Q + ++ R E +
Sbjct: 1296 KRDVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERSRERQERRIQVTLRKWERFETN 1355
Query: 2209 KETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFL 2268
KET+ + LF+ S + + ++L+ +EL Q T EF
Sbjct: 1356 KETVVRY--------LFQTGSSHERFLSFSSLESLS---------SELEQ-----TKEFS 1393
Query: 2269 EHKKHLEV-LHSLLKEISSHGL-PSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQE 2326
+ + + V +L+KE S L P +K L+ ++ ++ ++ K++EDT++E + + +
Sbjct: 1394 KRTESIAVQAENLVKEASEIPLGPQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKT 1453
Query: 2327 QLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVN 2386
+ D F ++L WI E K++ A + S D + Q K +++ EI+
Sbjct: 1454 KWDHFGSNFETLSVWITEKEKEL-------NALETSSSAMDMQISQIKVTIQ--EIESKL 1504
Query: 2387 NSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISH 2446
+S + L E A + +F IK +T I
Sbjct: 1505 SSIVGL--------------------------EEEAQSFAQFVTTGESARIKAKLTQIRR 1538
Query: 2447 GYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKM-NKTATKWQQTPAPTDTEAV 2505
E+L + + LS+ QK +E + Q + + +K A + + T+T V
Sbjct: 1539 YGEELREHAQCLEGTILGHLSQQQKFEENLRKIQQSVSEFEDKLAVPIKICSSATETYKV 1598
Query: 2506 KTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQ 2565
++++ L+ + + +++ + EA +Q +I + +E
Sbjct: 1599 ---LQEHMDLCQALESLSSAITAFSASARKVVNRDSCVQEAAALQQQYEDILRRAKE--- 1652
Query: 2566 LTIDRQQKLEESSNNLTQFQTVEAQLKQ---WLVEKELMVSVLG-PLSIDPNMLNTQRQQ 2621
RQ LE N L +Q +E +L WL E S +S D + + Q
Sbjct: 1653 ----RQTALE---NLLAHWQRLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQL 1705
Query: 2622 VQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDR 2681
+Q L E ++ Y +L + + S +D ++K L + ++W L ++ R
Sbjct: 1706 IQALQNEVVSQASFYSKLLQLKESLFSVASKDDVK--MMKLHLEQLDERWRDLPQIINKR 1763
Query: 2682 CDWIDQAIVKSTQYQSLLRSLSD--KLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQE 2739
+++ + + Q+ LL S S KL + + +S +++ H A+ + + A E
Sbjct: 1764 INFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQVALTRHKDHAA----E 1819
Query: 2740 IQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENH-------V 2792
++ +K +++ Q L +L + E L L + E + F++ Q E
Sbjct: 1820 VESKKGELQSLQGHLAKLGSLGRAEDLHL-LQGKAEDCFQLFEEASQVVERRQLALSHLA 1878
Query: 2793 QHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTA 2852
+ LQS + S +Q+ + +A K E D++E + D +K L
Sbjct: 1879 EFLQSHASLSGILRQLRQTVEATNSMNKNES----------DLIEKDLNDALQNAKAL-- 1926
Query: 2853 QSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKL--KESLEK 2910
E + +L K Q K Q + + D +V+ +N L K+S
Sbjct: 1927 -----ESAAVSLDGILSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQSEAD 1981
Query: 2911 ALK-----YKEQVETLWPWIDKCQNNLEEIKFCLDPAEG-ENSIAKLKSLQKEMDQHFGM 2964
AL +++Q E L I+ + ++ + + + + L+ E++ H
Sbjct: 1982 ALAVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHE 2041
Query: 2965 VELLNNTANSLLS-----VCEIDKE-----VVTDENKSLIQK--------VDMVTEQLHS 3006
+ L + A + E+D+E V D+ K LI + +D++ E +
Sbjct: 2042 LCWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNL 2101
Query: 3007 KKFC---LENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQA-YSNKYLTMLQTQQ 3062
K LEN + V++ + + + K H++ ++ Y K L ++
Sbjct: 2102 KSAVSKVLENASSVI-----VTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKG 2156
Query: 3063 KSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQV-ETIAQEHSTLSQQVDEKCSFLE 3121
K L + +L K + D + +D + T D L V E + + L + L
Sbjct: 2157 KHLLS-----ELKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLS 2211
Query: 3122 TKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMAS 3181
T+ + G N + +M + D+ L R E L++ + +K +LE L +
Sbjct: 2212 TRDEIEGWSNNCVPQMAENISNLDNHL-------RAEELLKEFESEVKNKALRLEELHSK 2264
Query: 3182 NDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQ-------AREEQVEGTI 3234
++ + K + ET PDL I+ DL + ++ + A+ A+ QVE I
Sbjct: 2265 VNDLKELTKNL----ETPPDLQFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFI 2320
Query: 3235 KRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQ 3294
+ +++K++E L ++E + L K QKE LQ +Q
Sbjct: 2321 NDITTWFTKVEES---LMNCAQNETCEA------------LKKVKDIQKE----LQSQQS 2361
Query: 3295 DVNWLGQGLIQSAAK--STSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQ 3352
+++ + L K S + L + + + + +++ ++ A LQE+L F
Sbjct: 2362 NISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLEK--HFS 2419
Query: 3353 DALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEK 3412
++++ W + + + + KV++A++ + + + + D +S ++ + +EG+
Sbjct: 2420 ESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAVTQEGQT 2479
Query: 3413 IATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLT 3472
+ I +Q++ + ++A L + + L+ + F + LN W+
Sbjct: 2480 LYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKLNLWIH 2539
Query: 3473 TIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSR---- 3528
+E+R N E +G + E+ ++++ L + ++ +SL LS R
Sbjct: 2540 EMEERF-NTENLGESKQHIPEK-------KNEVHKVEMFLGELLAARESLDKLSQRGQLL 2591
Query: 3529 --EDKDMVQSKLDFSQVW--YIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVH 3584
E Q SQ+ + + + + Q AL + E + W+ +
Sbjct: 2592 SEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAIQ 2651
Query: 3585 DKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRK----QNVDQALLNGLELLKQTTGDEV 3640
D+L+ S + L K+ S++ +DILL K ++ A+ G + L+ + +
Sbjct: 2652 DRLACAESTLGSKDTLEKRLSQI----QDILLMKGEGEVKLNMAIGKGEQALRSSNKEGQ 2707
Query: 3641 LIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYE 3700
+IQ +LE +K + DI S TLE + +L W++ V+ ++
Sbjct: 2708 RVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKI---- 2763
Query: 3701 TQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAED- 3759
E Q Q KE + +++L + + AL L+ ++RE EK E
Sbjct: 2764 ------EHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIA-KSRELYEKTEDESF 2816
Query: 3760 --------NERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDI 3811
++ + +K+ +++ + + A W+ +++L D+
Sbjct: 2817 KDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDM 2876
Query: 3812 RLEQDQTSAQLQVQKTF--TMEILRHK---------DIIDDLVKSGHKIMTACSEEEKQS 3860
+ T +L K + EI + ++ + SG ++M + +
Sbjct: 2877 SGDSSATQKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRAD 2936
Query: 3861 MKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAP 3920
K+ D V + + + S+ L + V Q + E+ L ++ L
Sbjct: 2937 WKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQLTLLEGK 2996
Query: 3921 ALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELS------PGEGFSIQEKYV 3974
+ E + + + +++ + + + +P + + +L S G+ + ++Y
Sbjct: 2997 NTD-EEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSGLIKEY- 3054
Query: 3975 AADTLYSQIKEDVKKRAVALDEAISQS-TQFHDKIDQILESLERIVERLRQPPSISAEVE 4033
+ L Q + + + L + ++ F + + + + + +S ++
Sbjct: 3055 --NCLCLQASKGCQNKEQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQ 3112
Query: 4034 KIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIW 4093
KI+E +SE++N + + E L ++ + AK +Q K+ W
Sbjct: 3113 KIQEFLSESENGQHKLNMMLSKGELL----STLLTKE-------KAKGIQAKVTAAKEDW 3161
Query: 4094 ENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQE 4153
+N H+ + ++E+ L ++ + F + + T+ + + + D +++Q+
Sbjct: 3162 KNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLSKTEKMVHESSNRLYDLPAKRREQQ 3221
Query: 4154 AAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRI 4213
+++ EEI + +L+ + +L G+ + + +L+S + +L+ K+++
Sbjct: 3222 KLQSVLEEIHCYEPQLNRLKEKAQQLWE--GQAASKSFRHRVSQLSSQYLALSNLTKEKV 3279
Query: 4214 DKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQ 4273
+L+ + Q+ G++ + DW+ A L S +D + + +L+ S +
Sbjct: 3280 SRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEALLSVKQE 3339
Query: 4274 QQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLAL 4333
++I+M+ + + E +L+ + E T+Q L +K +W SL I + +LEGAL
Sbjct: 3340 KEIQMKMIVTRGESVLQNTSPEGIP-TIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKW 3398
Query: 4334 GQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNK 4393
+Q + + W+ E L+E + + + L K +L +VL++ S +E +
Sbjct: 3399 TSYQDGVRQFSGWMDSMEANLNESERQHAELRDKTTMLGKAKLLNEEVLSYSSLLETIEV 3458
Query: 4394 AGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQ 4453
G + E Q +L+ L +R++ + E+ ++ + + +R + + +++ +
Sbjct: 3459 KGAGMTEHYV------TQLELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRDLKAFE 3512
Query: 4454 QWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPK 4513
WL + L L G T + L E+ + S++ + ++
Sbjct: 3513 VWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVLHTREDVIPSGIP 3572
Query: 4514 SAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLN 4573
AE D+ + +L++ W++ + +L+E +T+ +N Q WL AE+
Sbjct: 3573 QAE---DRALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEE--- 3626
Query: 4574 VASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLI 4633
K + EV ++R+++ E+ + S + +
Sbjct: 3627 -------------------KKWHEEVTAYRDEVEEVGARAQEILDESHVNSRMGCQ--AT 3665
Query: 4634 SVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDK 4693
+ SR++ ++ +++E+ + L++ + ++ + S +W + K+ + +A DK
Sbjct: 3666 QLTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFKN---VATKIDK 3722
Query: 4694 IKT-----QLAQHKEFQKSLGAKHSVYDTTNRTG-RSLKEKTSLADDNLK--LDDMLSEL 4745
+ T +L + K + HS+ + G R++K + L+ + D + +L
Sbjct: 3723 VDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQL 3782
Query: 4746 RDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVM 4805
++ T+ + LE+ L + +F+D +AL W+ + L + ++
Sbjct: 3783 KELTSTV----RKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKK 3838
Query: 4806 NLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSI 4865
+ +K+ Q+ + SV++++ L+E +D + +K ++ +L + ++ +C++
Sbjct: 3839 AQLSKYKSLQQTVLSHEPSVKSVREKGEALLELVQDVT--LKDKIDQLQSDYQDLCSIGK 3896
Query: 4866 SKQTRLEAALRQAEEFHSVVHALLEWLA---EAEQTLRFHGVLPDDEDALRTLIDQHKEF 4922
+ + + L+ A +A+ H L +D+ + +
Sbjct: 3897 AMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRM 3956
Query: 4923 MKKLEEKRAELNKATTMGDTV------LAICHPD-------------SITTIKHWITI-- 4961
+ LE EL K + DT+ L+ PD +I +KH+ +
Sbjct: 3957 YQSLEH---ELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRALQE 4013
Query: 4962 -------------------IRARFEEVLAWAKQHQQRLASA---LAGLIAKQELLEALLA 4999
++ +++ + +Q+L A G + L L
Sbjct: 4014 QARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQKLVQAQNLTQGWEEIKHLKSELWI 4073
Query: 5000 WLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDV----DKVTKTYKRRA 5055
+LQ A+ L + + E+ + ++++ + F++++ KQ V +KV K K+
Sbjct: 4074 YLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKKEE 4133
Query: 5056 ADPSSLQSHI 5065
+ +H+
Sbjct: 4134 SPEHKEINHL 4143
Score = 317 bits (813), Expect = 2e-85
Identities = 710/4024 (17%), Positives = 1549/4024 (38%), Gaps = 512/4024 (12%)
Query: 1325 LEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQL---NQQKMLVSEI 1381
L G ++Y + L++ I + Q + ++ + A QL +QQK I
Sbjct: 1235 LSNFGDCVQYKEIVKNSLEELISGSKEVQEQAEKILDTENLFEAQQLLLHHQQK--TKRI 1292
Query: 1382 EMKQSKMDECQKYAEQYSATVKDYELQTMT-YRAMVDSQQKSPVKRRRMQSSADLIIQEF 1440
K+ + + A+Q + D + + + +D ++S R R + + ++++
Sbjct: 1293 SAKKRDVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERS---RERQERRIQVTLRKW 1349
Query: 1441 MDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNIS--- 1497
T +V +Y+ G S +R SLE E +E+ KE K +I+
Sbjct: 1350 ERFETNKETVV----RYLFQTGSSHERFLSFS-SLESLSSE-LEQTKEFSKRTESIAVQA 1403
Query: 1498 -KTLKDAEKAGKPPFSKQ------KISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEE 1550
+K+A + P +KQ K E++ ++ L E ++T+++ K D
Sbjct: 1404 ENLVKEASEIPLGPQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKW-----DHF 1458
Query: 1551 RNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLL 1610
+ E + E + L L+ S ++ D+++ + + QE + KL I L
Sbjct: 1459 GSNFETLSVWITEK-----EKELNALETSSSAMDMQISQ--IKVTIQEIESKLSSIVGLE 1511
Query: 1611 TQTEN--RLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQA-LAEVVKNTENFLKE 1667
+ ++ + + E+ I ++++Y + E + ++G+ L++ K EN K
Sbjct: 1512 EEAQSFAQFVTTGESARIKAKLTQIRRYGEELREHAQCLEGTILGHLSQQQKFEENLRKI 1571
Query: 1668 NGEKLSQEDKALIEQKLNEAKI---KCEQLNLKAEQSKKELDKVVTT------------- 1711
EDK + K+ + K Q ++ Q+ + L +T
Sbjct: 1572 QQSVSEFEDKLAVPIKICSSATETYKVLQEHMDLCQALESLSSAITAFSASARKVVNRDS 1631
Query: 1712 ------AIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHF 1765
A++++ E + +++ +E +T +ENLL ++K+ + T
Sbjct: 1632 CVQEAAALQQQYEDI--LRRAKERQTALENLLAHWQRLEKE-----------LSSFLTWL 1678
Query: 1766 QEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIAT 1825
+ G+ K++ E D + + + + Q ++A +++SQ A+
Sbjct: 1679 ERGEAKASSPEMD--------------ISADRVKVEGELQLIQALQNEVVSQ------AS 1718
Query: 1826 QSAQVLLEKQGQY--LSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFD 1883
+++L K+ + S ++ + ++ ++++L + K++ S+ E ++FD
Sbjct: 1719 FYSKLLQLKESLFSVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFD 1778
Query: 1884 ADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNR 1943
F W++ EL+ I L R K + +V S KG+L+ ++ G+
Sbjct: 1779 ELLLSFSVWIKLFLSELQT--TSEISIMDHQVALTRHKDHAAEVESKKGELQ--SLQGHL 1834
Query: 1944 VLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNN---LKDLVDKY 2000
K+ + ++ A D F+ V+ L L +
Sbjct: 1835 A-------------KLGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLAEFL 1881
Query: 2001 QHYEDASCGLLAGL-QACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEK 2059
Q + S G+L L Q EAT S + +E ++ K+L L+ KAL+ S V+++
Sbjct: 1882 QSHASLS-GILRQLRQTVEATNSMNKNESDLIE-KDLNDALQNAKALE----SAAVSLDG 1935
Query: 2060 LKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDG 2119
+ A+ L S + + T D + G E + + + + + QD
Sbjct: 1936 ILSKAQYHLKIGSS--EQRTSCRATADQLCGEVERIQNLLGTKQSEADALAVLKKAFQDQ 1993
Query: 2120 LDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFM 2179
+E+L + ++E ++ ALQ + LE ++ + + + +K K+
Sbjct: 1994 KEELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHELCWLKDKAKQIA 2053
Query: 2180 ETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETK 2239
+ D + A + ++ L + + E + L + ++NL + LE
Sbjct: 2054 QK-DVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVSKVLENA 2112
Query: 2240 TQAL-TEVDVPGKDVTELS-------------QYMQESTSEFLEHKKHLEVLHSLLKEIS 2285
+ + T + KD +L Y Q+ F KHL S LK+I
Sbjct: 2113 SSVIVTRTTI--KDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLL---SELKKIH 2167
Query: 2286 SHG---LPSDKALVLEKTNNLSKKFKEMEDTIKEKK---EAVTSCQEQLDAFQVLVKSLK 2339
S + +D ++K ++S+K +E D ++ + V S +++++ +
Sbjct: 2168 SSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWS------N 2221
Query: 2340 SWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQ-KVNNSGISLCNLISA 2398
+ + + + + + AE+L K E K + +L+ E+ KVN+ L L
Sbjct: 2222 NCVPQMAENISNLDNHLRAEELLKEFESEVKNK---ALRLEELHSKVND----LKELTKN 2274
Query: 2399 VTTP----------------AKAIAAVKSGGAVLNGEGTATNTEEFWAN--KGLTSIKKD 2440
+ TP AK I V G + + +T E+F + T +++
Sbjct: 2275 LETPPDLQFIEADLMQKLEHAKEITEVAKG-TLKDFTAQSTQVEKFINDITTWFTKVEES 2333
Query: 2441 MTDISHGYEDLGLL-LKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAP 2499
+ + + L +KD EL ++ S + QE +++ + + T
Sbjct: 2334 LMNCAQNETCEALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLI 2393
Query: 2500 TDTEAV-----KTQVEQNKSFEAELKQNVNKVQE---------------------LKDKL 2533
EAV KTQ +S E +++ + QE L+ KL
Sbjct: 2394 KKHEAVSQLCSKTQASLQESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKL 2453
Query: 2534 TEL----------------LEENPDTPEAPRWKQM-------LTEIDSKWQELNQLTIDR 2570
+L + + T A KQ+ +T+ + ++Q + +
Sbjct: 2454 HDLQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKD 2513
Query: 2571 QQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSV--LGPLSIDPNMLNTQRQQVQILLQE 2628
+Q L++ ++ L F+ +L W+ E E + LG + +V++ L E
Sbjct: 2514 KQALQDCASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGE 2573
Query: 2629 FATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQA 2688
+ ++L+ GQ +LS G G + QL Q +T + C A
Sbjct: 2574 LLAARESLDKLSQRGQ-LLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQ---VA 2629
Query: 2689 IVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIK 2748
+ + + L+S+ + + ++L+ + + D + ++L Q + + + + ++K
Sbjct: 2630 LQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDIL--LMKGEGEVK 2687
Query: 2749 VAQALCEDLSAL-VKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQ 2807
+ A+ + AL + + + QLE + + + D+ + + L+S + + + +
Sbjct: 2688 LNMAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVE 2747
Query: 2808 MSRDFQAWLDTKKEEQNKSHPISAK---------LDVLESLIKDHKDFSKTLTAQSHMYE 2858
+ W+++ +Q HP+ + LD L+S++ + +D ++ L
Sbjct: 2748 RKNQLEQWMESV--DQKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRAL-------H 2798
Query: 2859 KTIAEGENLLLKTQG-SEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQ 2917
+ IA+ L KT+ S K Q +L KT ++ KE+ K++E ++ L Y +
Sbjct: 2799 RLIAKSRELYEKTEDESFKDTAQEEL---KTQFNDIMTVAKEKMRKVEEIVKDHLMYLDA 2855
Query: 2918 VETLWPWIDKC-----------------QNNLEEIKFCLDPAE-GENSIAKLKSLQKEMD 2959
V W+ Q L +IK +D E G + +++++SL E+
Sbjct: 2856 VHEFTDWLHSAKEELHRWSDMSGDSSATQKKLSKIKELIDSREIGASRLSRVESLAPEVK 2915
Query: 2960 QHFGM--VELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQK 3017
Q+ EL++ +L + + ++ V L V + + + Q
Sbjct: 2916 QNTTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQA 2975
Query: 3018 FKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKR 3077
++F + K +QL + + + + + L LQ + + LK Q++ R
Sbjct: 2976 LEQFSALLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCR 3035
Query: 3078 LAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREM 3137
++DL + G + +E++ L Q + C E LQ +
Sbjct: 3036 FSRDLSTYSGKVSG----------LIKEYNCLCLQASKGCQNKEQILQ---------QRF 3076
Query: 3138 FSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEE 3197
F +F L + + + + L+K++ ++ ++N MML+ E
Sbjct: 3077 RKAFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSKGE 3136
Query: 3198 TSPDLV------GIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILL 3251
L+ GI+ + A + +E +E ++++F + L
Sbjct: 3137 LLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWL 3196
Query: 3252 QKAEE--HEESQGPVGMETETINQQLNMFKVFQKEEIEP----LQGKQQDVNWLGQGLIQ 3305
K E+ HE S + + QQ + + EP L+ K Q + W GQ
Sbjct: 3197 SKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQL-WEGQ---- 3251
Query: 3306 SAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDT 3365
+A+KS H + +++++ L+ ++ ++L + +F ++ L WM D
Sbjct: 3252 AASKS-----FRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDA 3306
Query: 3366 EELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKI 3425
++ + P+++ V+ ++ + + L + +++ +++I GE + P I
Sbjct: 3307 IHMLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTI 3366
Query: 3426 LKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIG 3485
+QL + W +LL+ QLEG + + + + W+ ++E L E
Sbjct: 3367 QQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQH 3426
Query: 3486 TQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWY 3545
+ + + K L +++++++ L G + + + Q +L Q Y
Sbjct: 3427 AELRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMT------EHYVTQLELQDLQERY 3480
Query: 3546 IEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQS 3605
IQE++ ++ + + + D WL + +KL + SV + ++
Sbjct: 3481 RAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAH---THET 3537
Query: 3606 ELRVLQEDILLRKQNVDQALLNG-LELLKQTTGDEVLIIQDK-LEAIKARYKDITKLSTD 3663
LR LQE L QALLN L + + +D+ LE+++ ++ ++
Sbjct: 3538 TLRDLQE--LQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSE 3595
Query: 3664 VAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEA 3723
+ R + +++ WL E + E + +E + R +E+ E+
Sbjct: 3596 TRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKKWHEEVTAYR-DEVEEVGARAQEILDES 3654
Query: 3724 KNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILR 3783
N + +++S RY+ + + ++++ ++ I
Sbjct: 3655 HVNSRMGCQATQLTS-----------------------RYQALLLQVLEQIKFLEEEIQS 3691
Query: 3784 SQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEIL-----RHKDI 3838
++ + + + W T K + + + D+ + +K T+E+L + +
Sbjct: 3692 LEESESSLSSYSDWYGSTHKNFKN---VATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSL 3748
Query: 3839 IDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWE 3898
+ + G + + E E + ++K++ ++ + + ++ LE+ L +F +
Sbjct: 3749 LKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSD 3808
Query: 3899 TYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQL 3958
+ L W+ EY+ + EE + + E K + K +
Sbjct: 3809 KCKALTQWIA--------------EYQEILHVPEEPKME---LYEKKAQLSKYKSLQQTV 3851
Query: 3959 LELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERI 4018
L P + V+++ AL E + Q DKIDQ+ + +
Sbjct: 3852 LSHEPSV-------------------KSVREKGEALLELV-QDVTLKDKIDQLQSDYQDL 3891
Query: 4019 VERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDIS 4078
S K + ++ + L+ +G+ +I +
Sbjct: 3892 C--------------------SIGKAMMEEIAGFEDRLNNLQMKGDTLIGQC-------- 3923
Query: 4079 AKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCD-------HMSLIVTIKDT 4131
A +Q KL Q N+H ++ + + A++ + H+S T++
Sbjct: 3924 ADHLQAKLKQ------NVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQC 3977
Query: 4132 QDFIRDLEDPGIDPSVVKQQQEAAETIRE--EIDGLQEELDIVINLGSELIAACGEPDKP 4189
Q ++ ++ P ++PS + AE I++ LQE+ ++L L + C +
Sbjct: 3978 QAWLSAVQ-PDLEPSP-QPPLSRAEAIKQVKHFRALQEQARTYLDL---LCSMC-DLSNA 4031
Query: 4190 IVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSP 4249
VK + ++ ++ + ++ + + Q + + ++ ++ A +L +M
Sbjct: 4032 SVKTTAKDIQQTEQTIEQ----KLVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNMKR 4087
Query: 4250 IGTDLET--VKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLME 4307
++LE + + ++K F + +Q + + + L KK EES +H + L +
Sbjct: 4088 RHSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKK--EESPEHKEINHLND 4145
Query: 4308 LKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAI 4367
W L + N + E L + ++ + +L + A+
Sbjct: 4146 Q---WLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWDNLARSDAESTAV 4202
Query: 4368 EIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEK 4427
+E K L + + +E + +IE ++ ++ + L QRW + +
Sbjct: 4203 HLEALKKLALA--LQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDL 4260
Query: 4428 TEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVC 4487
+++ Q L + ++L +W + + ++ + P+ A+ L H+ +C
Sbjct: 4261 IKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAIC 4320
Query: 4488 AAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEA 4547
+ EAK+ KSL++ +++A + I + +++ + + + +R+ L +A
Sbjct: 4321 SELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKA 4380
Query: 4548 LNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQII 4607
L+ +F ++ + + Q E+ + L+ D V Q+ K + +++ ++
Sbjct: 4381 LSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQNEVT 4440
Query: 4608 ELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAW 4667
L G L +Q+ + L +QS ++ V+Q+ R + L+ K F E +
Sbjct: 4441 GLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKEDF 4500
Query: 4668 SKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKE 4727
K WL++++ E+ + N+ ++ TQLA+++ + ++ T RTG+++
Sbjct: 4501 DKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQTILP 4560
Query: 4728 KTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRV 4787
+ D + L + L+ L +++ I + ++ K++EA+L ++ ++ L +
Sbjct: 4561 SLNEVDHSY-LSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLIELTTQSLSEL 4619
Query: 4788 EPQLAEDQPVHGD--IDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSS- 4844
E Q V D ++ ++L D +A E+ +V L + EG R
Sbjct: 4620 EAQFLRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVDELNQKK----EGFRSTGQP 4675
Query: 4845 WVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWL--AEAEQTLRFH 4902
W +M L T + + + + + LE +E + L L + EQ+
Sbjct: 4676 WQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNE 4735
Query: 4903 GVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITII 4962
LP +E + + L++ L + T + + P + +H I
Sbjct: 4736 ETLPAEEK-----LKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSW 4790
Query: 4963 RARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLT-----DKDKEVIP 5017
+ + + + + S + I Q + L WL+ + L+ D + + I
Sbjct: 4791 QGELKLLTSAIGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQ 4850
Query: 5018 QEIEEVKALIAEHQTFMEEMTR-KQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRK 5076
+EI +++ E Q+ + M + +K TK + +AD + + LD
Sbjct: 4851 EEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELDGDIQEAL 4910
Query: 5077 RFPASSLYPSGSQTQIETKNPRVNLLVSKWQQVWLLALERRRKLNDALDRLEELREFANF 5136
R ++L SQ Q ++ QV+ A ND L+ +EL + A
Sbjct: 4911 RTRQATLTEIYSQCQ-------------RYYQVFQAA-------NDWLEDAQELLQLAGN 4950
Query: 5137 DFDI 5140
D+
Sbjct: 4951 GLDV 4954
Score = 313 bits (801), Expect = 4e-84
Identities = 865/4757 (18%), Positives = 1840/4757 (38%), Gaps = 697/4757 (14%)
Query: 645 MKFVQDLLNWVDEMQVQLDR-TEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEI 703
+KF+++ + ++E + L ++W S +N KNV I++ ++ + K+ +
Sbjct: 3682 IKFLEEEIQSLEESESSLSSYSDWYG------STHKNFKNVATKIDKVDTVMMGKKLKTL 3735
Query: 704 QMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEV 763
++ L +E ++ L + ER + L + + I + ++ +E+
Sbjct: 3736 EVL----------LKDMEKGHSLLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKEL 3785
Query: 764 AYDWSERNTNIARKKDYH-----AELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEA 818
+ R ++ +K H ++ + L Q + + + E+ +E + + +
Sbjct: 3786 TS--TVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSK 3843
Query: 819 YRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSS 878
Y++ QT +L V+ ++ A E D L++ D +Q Y
Sbjct: 3844 YKSLQQT----VLSHEPSVKSVREKGEALLELVQDVT-----LKDKIDQLQSDY------ 3888
Query: 879 SIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSI-------- 930
+DL EE+ ++ + NL K T+I + LK ++
Sbjct: 3889 -----QDLCSIGKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTK 3943
Query: 931 -PIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAV 989
AIC Q +Y+ E L + R A+ P + + PP A
Sbjct: 3944 DSYSAICSTAQ---RMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAE 4000
Query: 990 DLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVL 1049
+ +Q ++ L ++ + + S L N AS+KT + QQ
Sbjct: 4001 AI-----KQVKHFRALQEQARTYLDLLCSMCDLSN----------ASVKTTAK-DIQQTE 4044
Query: 1050 SNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAERE--EQEESVYNL 1107
++ + +Q +I L+ E+ + Q + L++ +R E E ++
Sbjct: 4045 QTIEQKLVQAQNLTQ-----GWEEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQN 4099
Query: 1108 YISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLK--KELERLKDDLGT 1165
+S+V++ +L++ + + + + E V ++T++E+ KE+ L D
Sbjct: 4100 MVSQVKDFVKKLQSKQASV----------NTIIEKVNKLTKKEESPEHKEINHLND---- 4145
Query: 1166 ITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAE 1225
++ S+++ R E ++ + ++ +++K T L + A
Sbjct: 4146 ------QWLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWDNLARSDAES 4199
Query: 1226 ALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDE 1285
V L LK+ + E++ L+D+ QK
Sbjct: 4200 TAVHL----------------------EALKKLALALQERKYAIEDLKDQKQK------- 4230
Query: 1286 MFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDW 1345
M + D + KE+ L +RW + I +++ + L + + L +W
Sbjct: 4231 MIEHLNLDDKELV--KEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEW 4288
Query: 1346 I--QQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVK 1403
QQ + Q P+ ++ L L + SE+E KQ + K A++ A +
Sbjct: 4289 AEEQQPNIAEALKQSPPPDMAQNL---LMDHLAICSELEAKQMLLKSLIKDADRVMADLG 4345
Query: 1404 DYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGD 1463
E Q + +A+ D+Q + +DL+ Q R ++ TQ++
Sbjct: 4346 LNERQVIQ-KALSDAQS-------HVNCLSDLVGQR----RKYLNKALSEKTQFLMAVFQ 4393
Query: 1464 SLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEIST 1523
+ ++++ E+ + +EH+ L VS KT K A+ + K E++
Sbjct: 4394 ATSQIQQHERKIMF--REHICL---LPDDVSKQVKTCKSAQ-------ASLKTYQNEVTG 4441
Query: 1524 KKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSG 1583
Q E ++ + T++E++E+ +++ LQ Y+ + + +LQE
Sbjct: 4442 LWAQGRELMKEV-----------TEQEKSEVLGKLQELQSVYDSVLQKCSHRLQE----- 4485
Query: 1584 DVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEEL 1643
+E+ +V+ + +KE C L Q + ++ E ++ + + EL +K + +
Sbjct: 4486 ---LEKNLVSRKH--FKEDFDKACHWLKQAD--IVTFPEINLMNESS-ELHTQLAKYQNI 4537
Query: 1644 QKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKK 1703
+ L + + + L L++ D + + +KLN Q N+ +K
Sbjct: 4538 LEQSPEYENLLLTLQRTGQTILPS----LNEVDHSYLSEKLNALP---RQFNVIVALAKD 4590
Query: 1704 ELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGT 1763
+ KV AI E + ++ +S +++E +S V D + +
Sbjct: 4591 KFYKV-QEAILARKEYASLIELTTQSLSELEAQFLRMSKVPTD----------LAVEEAL 4639
Query: 1764 HFQEG-----DGKSAIGEE-DEVNGNLLETDVDGQVGTTQENLN--QQYQKVKAQHEKII 1815
Q+G D + +GE DE+N GQ + L+ Y ++K Q E+ +
Sbjct: 4640 SLQDGCRAILDEVAGLGEAVDELNQKKEGFRSTGQPWQPDKMLHLVTLYHRLKRQTEQRV 4699
Query: 1816 SQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSL 1875
S ++ T SA EK Q L E+ K++KE + +E+K+K+ HSL
Sbjct: 4700 S----LLEDTTSAYQEHEKMCQQL-----ERQLKSVKEEQSKVNEETLPAEEKLKMYHSL 4750
Query: 1876 QEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLR 1935
L Q S L+ + +D+ + L +K+ + S +G+L+
Sbjct: 4751 AGSL--------------QDSGIVLKRVTIHLEDLAPHLDPLAYEKA-RHQIQSWQGELK 4795
Query: 1936 YITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKD 1995
+T + + E C R +D E+ R LD R ++ S L NL+D
Sbjct: 4796 LLT---SAIGETVTECESRMVQSIDFQT---EMSRSLDWLR-RVKAELSGPVYLDLNLQD 4848
Query: 1996 LVDKYQ----HYED--ASCGLLAGLQACEATASKHLSEPIAVDPKN-----------LQR 2038
+ ++ + H E+ +S ++ L E E I+ D ++ +Q
Sbjct: 4849 IQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELDGDIQE 4908
Query: 2039 QLEETKALQGQISSQ--------QVAVEKLKKTAEVLLDARGSL---------------- 2074
L +A +I SQ Q A + L+ E+L A L
Sbjct: 4909 ALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESAEENLKSHMEFF 4968
Query: 2075 ---------LPAKNDIQKTLDDIV---GRYEDLSKSVNE---------RNEKLQITLTRS 2113
L + + TLD ++ G+ EDL + V R+ Q+ L +
Sbjct: 4969 STEDQFHSNLEELHSLVATLDPLIKPTGK-EDLEQKVASLELRSQRMSRDSGAQVDLLQR 5027
Query: 2114 LSVQ-----DGLDEMLDWMGNVESSLKEQGQVPLNST-ALQDIISKNIMLEQDIAGRQSS 2167
+ Q +E+++ M + E L E + +S+ ++ +S++ L +
Sbjct: 5028 CTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEK 5087
Query: 2168 INAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEE---------- 2217
I A+ EK + +T + ++ ++L M + R++ ++ +E+
Sbjct: 5088 IVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNN 5147
Query: 2218 -LKTKVELFENLSEKL---QTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKH 2273
+K E+ + L +KL +K + LT ++ V EL Q Q+S L +
Sbjct: 5148 KVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQ--QQSALGMLRQQTL 5205
Query: 2274 LEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQV 2333
S+L++ + P ++ ++++ + + M++ +K + V + + +
Sbjct: 5206 -----SMLQD-GAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVET 5259
Query: 2334 LVKSLKSWIKETTK----------------KVPIVQPSFGAEDLGKSLEDTKK------- 2370
+ S+K W++ET + ++ + + + +++ K E+ K+
Sbjct: 5260 QINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAEEQKEKYLGLYT 5319
Query: 2371 -LQEKWSLKTPEI------------------------QKVNNSGISLCNLISAVTTPAKA 2405
L + SL+ E+ Q+++ L ++ + T KA
Sbjct: 5320 ILPSELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKA 5379
Query: 2406 ----IAAVKSGGAVLNGEGTATNT---------EEFWANKGLTS--IKKDMTDISHGYED 2450
+ K+ VL E N+ ++F G + K + ++ ++
Sbjct: 5380 KTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQ 5439
Query: 2451 LGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTA---TKWQQTPAPTDTEAV-K 2506
++++++LN S L++ E +++W++K A W + + +
Sbjct: 5440 TIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYILHQ 5499
Query: 2507 TQVEQNKSFEAELKQNVNKVQELK-----DKLTELLEENPDTPEAPRW--KQMLTEIDSK 2559
T +E++K ++EL+ K+Q L +K+++ + E E R K L +
Sbjct: 5500 TLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNLQDA 5559
Query: 2560 WQELNQLTIDR---QQKLEESSNNLTQFQTVEAQLKQWLVEKELMVS------------- 2603
+++ + + Q LE++ LT + LK+ L ++ ++S
Sbjct: 5560 AKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQ 5619
Query: 2604 -----------VLGPLSIDPNMLNTQRQQVQI---------LLQEFATRKPQYEQ----- 2638
V+ L + L Q + ++ ++Q + QYEQ
Sbjct: 5620 LCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHL 5679
Query: 2639 ---LTAAGQGILSRPGEDPSLRGIVK-----EQLAAVTQKWDSLTGQLSDRCDWIDQAIV 2690
+ A + I +P +++ + E+LA + + L+ +C +
Sbjct: 5680 QQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAK 5739
Query: 2691 KSTQYQSL--LRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIK 2748
+T ++ + L++ DLD +L + S HP + + + +E +
Sbjct: 5740 HATMLLTVTEVEGLAEGTEDLDGELLPT--PSAHPSVVMMTAGRCHTLLSPVTEESGEEG 5797
Query: 2749 VAQAL-----CEDLSALVKEE--------YLKAELSRQLE----------GILKSFKD-- 2783
+ C S + + Y +A + +L+ + F +
Sbjct: 5798 TNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPG 5857
Query: 2784 VEQKAENHVQHLQSACAS-SHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKD 2842
+E A + LQ + + + + R L+ +++ Q+ IS K++ +E + +
Sbjct: 5858 LEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSE 5917
Query: 2843 HKDFSKTLTAQSHMYEKTIAEGENLLLKTQ--------------------GSEKAALQLQ 2882
+ ++ +S M E E L+L+ + +E+ ALQ
Sbjct: 5918 SPEPGRS--PESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQST 5975
Query: 2883 LNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPW---IDKCQNNLEEIKFCL 2939
L + T + + L+E L L+ + Q + L + D+ + L K L
Sbjct: 5976 LTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATL 6035
Query: 2940 DPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDM 2999
D A L ++ MD +++ N V + + V +EN L K
Sbjct: 6036 DTA--------LSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHT 6087
Query: 3000 V--TEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCA---KEQLDIHDSLGSQAYSNKY 3054
EQL K L + E Q + + +Q KE+ D+ + ++
Sbjct: 6088 KDEAEQLAGK---LRRLKGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEW 6144
Query: 3055 LTMLQTQ--QKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQ 3112
L +T Q+ +L+ Q +L + LA+ + S + ++L+Q HS
Sbjct: 6145 LAQARTTWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQ-------HSAAETS 6197
Query: 3113 VD--EKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKA 3170
D EK L +L G + +M ++ E + KQK
Sbjct: 6198 GDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESLHQEFST------------KQKLLQNV 6245
Query: 3171 FLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQV 3230
++ E ++ S N + + + + D + L+ L++ ++ ++ + Q
Sbjct: 6246 LEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQ- 6304
Query: 3231 EGTIKRLEEFYSKLKEFSILLQKAEEH---EESQGPVGMETETINQQLNMFKVFQKEEIE 3287
+I ++ Y + S L EE + P ET NQ+ + K+ E
Sbjct: 6305 --SIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQE-----ILAKDIKE 6357
Query: 3288 PLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLH 3347
+ ++ N Q ++ + +E L + R L+ V QR Q++E L
Sbjct: 6358 MSEEMDKNKNLFSQAFPENG---DNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQ 6414
Query: 3348 CGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIK 3407
FQ+ L+ L + + D + ++ QK + + V QI+ + + L + + + +K
Sbjct: 6415 ILNFQNDLKVLFTSLADNKYIIL-QKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELK 6473
Query: 3408 REGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPL 3467
R G+K+ +P+ +++LS L ++ L+ +R L + Q+ L+ L
Sbjct: 6474 RRGDKLQVE-QPS-----MQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDL 6527
Query: 3468 NEWLTTIEKRLVNCEPIGTQASK-LEEQIAQHKALEDDIINHNKHLHQAVSIGQSL--KV 3524
+ L T ++++ + I + + +++ + +HK + +H + + ++L K+
Sbjct: 6528 ADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESH-------MILTETLFRKI 6580
Query: 3525 LSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVH 3584
+S K+ +Q + +++H R L+ L ED+ EL L V
Sbjct: 6581 ISFAVQKETQFHTELMAQA--SAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVE 6638
Query: 3585 DKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQ 3644
+ + + + + + L + + + L+ + + + Q L +G LL + + ++
Sbjct: 6639 SSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSD---LE 6695
Query: 3645 DKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQ-V 3703
+L + + T + LE L+ R S +L WL + L + Q V
Sbjct: 6696 SQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSV 6755
Query: 3704 LKGEEASQAQMRPK---ELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDN 3760
+E + E KE +L S+ + LL L ++ D+
Sbjct: 6756 TVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELSRIDS 6815
Query: 3761 ERYRLVSD--TITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDI---RLEQ 3815
+ L+++ + +K+ ++ L S+ A +SWI+ E + D +
Sbjct: 6816 QWTDLLTNIPAVQEKLHQLQMDKLPSRH---AISEVMSWISLMENVIQKDEDNIKNSIGY 6872
Query: 3816 DQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMK----KKLDKVLKN 3871
LQ K F ++I K + D V +++ E K+S K ++L + K+
Sbjct: 6873 KAIHEYLQKYKGFKIDI-NCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKS 6931
Query: 3872 YDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQ 3931
+ + + +E+ LE +++ + L W ETQ + + +++
Sbjct: 6932 WQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWF-ETQEKRLKQQHRIGDQASVQNAL 6990
Query: 3932 EEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQ--------EKYVAADTLYSQI 3983
++ + L +LI + ++K+ + G L++ + SI + + D + Q+
Sbjct: 6991 KDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQL 7050
Query: 3984 KEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENK 4043
K +K LD+ S F DKI+ L + R R ++ +E ++ Q+ +
Sbjct: 7051 KILLKS---VLDQWSSHKVAF-DKINSYLMEARYSLSRFRL---LTGSLEAVQVQVDNLQ 7103
Query: 4044 NVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEER 4103
N+ D+EK + + +++ + + + L ++ W N+ + E+
Sbjct: 7104 NLQDDLEKQERSLQKFGSITNQLLKECHPP----VTETLTNTLKEVNMRWNNLLEEIAEQ 7159
Query: 4104 EAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQ----EAAETIR 4159
+++L +++ T++ +D +L + + + + +
Sbjct: 7160 LQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCNDLL 7219
Query: 4160 EEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEA 4219
+ + +++ L + LG +L ++ L+ +L +A + L+
Sbjct: 7220 KGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAG 7279
Query: 4220 MQAAVQYQDGLQAVFDWVDIAGGKLASMSPI-GTDLETVKQQIEELKQFKSEAYQQQIEM 4278
+ + L+A+ W+ A L P +DL T+++++EELK + ++
Sbjct: 7280 VLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDL 7339
Query: 4279 ERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQH 4338
+RLN EL + + + +Q+ L W + + R KL+ LL F
Sbjct: 7340 DRLN---ELGYRLPLNDKEIKRMQN----LNRHWSLISSQTTERFSKLQSFLLQHQTFLE 7392
Query: 4339 ALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDL 4398
+ + +L TE L+ + + G+ + + + H + Q ++ + Q + ++ G L
Sbjct: 7393 KCETWMEFLVQTEQKLAVE--ISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRL 7450
Query: 4399 IESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTD 4458
+E ++ KL +L+ +WQ V+ + +QR+ +D +RQ + + E L++WL +
Sbjct: 7451 LEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVE 7510
Query: 4459 TERHLLASKPLGGLPETAKEQLNVHMEVC---AAFEAKEETYKSLMQKGQQMLARCPKSA 4515
L LG +P ++ + EV F ++ +Y ++ G+Q+L A
Sbjct: 7511 VS--YLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGA 7568
Query: 4516 ETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVA 4575
E + ++ ++EKW+S +L E+K KL L + + D + L ++ L+
Sbjct: 7569 EAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLS-Q 7627
Query: 4576 SRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISV 4635
S P + Q+ K N V S + + +L L + D+ ++ + +
Sbjct: 7628 SLPDHHEELHAEQM-RCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELL 7686
Query: 4636 QSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLE--ESEKSLDSELEIANDPDK 4693
Q +WE++ +L R + + + F E +L EWL ES+ S + ++ I +K
Sbjct: 7687 QRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEK 7746
Query: 4694 IKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTIC 4753
+K K++Q+ + + G L K S +++ L ++ D+W +
Sbjct: 7747 LK------KDYQEEIAIAQENKIQLQQMGERLA-KASHESKASEIEYKLGKVNDRWQHLL 7799
Query: 4754 GKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDI---DLVMNLIDN 4810
R KL+E L+ Q + +L WL +E +LA+ P+ D + + ++
Sbjct: 7800 DLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAK--PIVYDSCNSEEIQRKLNE 7857
Query: 4811 HKAFQKELGKRTSSVQALKRSARELI---EGSRDDSSWVKVQM--QELSTRWETVCALSI 4865
+ Q+++ K ++ V ++ L+ + D+ +Q + L RW +CA+S+
Sbjct: 7858 QQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSM 7917
Query: 4866 SKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKK 4925
++ ++E R ++F +WL +E+T F P + T+ KE +KK
Sbjct: 7918 ERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAF----PSSSGVIYTVA---KEELKK 7970
Query: 4926 LEEKRAELNKATTMGDTV-------LAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQ 4978
E + ++++ T + + DS ++K + R++ + Q+
Sbjct: 7971 FEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNL-------QK 8023
Query: 4979 RLASALAGL---IAKQELLE----ALLAWLQWAETTLTDKDKEVIPQEIE-EVKALIAEH 5030
R+ S L L I ++E E ++L WL + LT+ I E +V+A I +
Sbjct: 8024 RVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTN-----IEHFSECDVQAKIKQL 8078
Query: 5031 QTFMEEMTRKQPDVDKV 5047
+ F +E++ ++++
Sbjct: 8079 KAFQQEISLNHNKIEQI 8095
Score = 312 bits (799), Expect = 7e-84
Identities = 772/4312 (17%), Positives = 1671/4312 (38%), Gaps = 503/4312 (11%)
Query: 1070 SGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQ 1129
S S + ++ V Q + L S E+E + +++ + R++ + + Q
Sbjct: 1482 SSSAMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIKAK------LTQ 1535
Query: 1130 IRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSE 1189
IR E H T L ++ ++ +++L I EF + A + + +E
Sbjct: 1536 IRRYGEELREHAQCLEGTILGHLSQQ-QKFEENLRKIQQSVSEFEDKLAVPIKICSSATE 1594
Query: 1190 LNVVLQN----MNQVYSMSSTYIDKLKTVNLVLKN---TQAAEALVKLYETKLCEE---- 1238
VLQ + S+SS + V+ Q A AL + YE L
Sbjct: 1595 TYKVLQEHMDLCQALESLSSAITAFSASARKVVNRDSCVQEAAALQQQYEDILRRAKERQ 1654
Query: 1239 ---EAVIADKNNIENLISTLKQW------------------RSEVDEKRQVFHALEDEL- 1276
E ++A +E +S+ W R +V+ + Q+ AL++E+
Sbjct: 1655 TALENLLAHWQRLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEVV 1714
Query: 1277 ------QKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGK 1330
K + + +F + D+ K +QL ERW+++ I+ R+ L+ +
Sbjct: 1715 SQASFYSKLLQLKESLFSVASKDDVKM--MKLHLEQLDERWRDLPQIINKRINFLQSVVA 1772
Query: 1331 SLKYYRDTYHPLDDWIQ----QVETTQR-KIQENQPENSKTLATQLNQQKMLVSEIEMKQ 1385
+ + + WI+ +++TT I ++Q L + K +E+E K+
Sbjct: 1773 EHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQ--------VALTRHKDHAAEVESKK 1824
Query: 1386 SKMDECQKYAEQYSATVKDYELQTMTYRA----MVDSQQKSPVKRRRMQSSADLIIQEFM 1441
++ Q + + + + +L + +A + + V+RR++ S + EF+
Sbjct: 1825 GELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSH---LAEFL 1881
Query: 1442 DLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLK 1501
+ ++ + Q ++ A +S+ + E + +E++ + ++ AK L+ ++ L
Sbjct: 1882 QSHASLSGILRQLRQTVE-ATNSMNKNESD--LIEKDLNDALQNAKALESAAVSLDGILS 1938
Query: 1502 DAEKAGKPPFSKQKIS----SEEISTKKEQLSEALQTIQ-----LFLAKHG--------- 1543
A+ K S+Q+ S ++++ + E++ L T Q L + K
Sbjct: 1939 KAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQSEADALAVLKKAFQDQKEELL 1998
Query: 1544 ------DKMTDEER----------------NELEKQVKTLQESYNLLFSESLKQLQESQT 1581
++ TD+ER N+LE ++ + + L + KQ+ +
Sbjct: 1999 KSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHELCWL-KDKAKQIAQKDV 2057
Query: 1582 SGDVKVEEKI---------VAERQQEYKEKLQGICDLLTQTEN------RLIGHQEAFMI 1626
+ +V+ +I E + + G+ DL+ + +N +++ + + ++
Sbjct: 2058 AFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVSKVLENASSVIV 2117
Query: 1627 GDGTV----ELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQ 1682
T+ +LK SK E + M + L ++ L E +K+ D +L++
Sbjct: 2118 TRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSEL-KKIHSSDFSLVKT 2176
Query: 1683 KLNEAKIKCEQLNLKAEQSKKEL-------DKVVTTAIKEETEKVAAVKQLEESKTKIEN 1735
+ K ++ K E++ L D V++T + E V Q+ E+ + ++N
Sbjct: 2177 DMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLDN 2236
Query: 1736 -------LLDWLSNVDKDSERAGTKHKQVIEQN----------GTHFQEGDGKSAIGEED 1778
L ++ S V + R H +V + F E D +
Sbjct: 2237 HLRAEELLKEFESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAK 2296
Query: 1779 EVNGNLLETDVDGQVGTTQ-----ENLNQQYQKVK------AQHE------------KII 1815
E+ T D +TQ ++ + KV+ AQ+E K +
Sbjct: 2297 EITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCAQNETCEALKKVKDIQKEL 2356
Query: 1816 SQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSL 1875
Q+ I +TQ L + E E L + M L +E A S+ K SL
Sbjct: 2357 QSQQSNISSTQEN---LNSLCRKYHSAELESLGRAMTGLIKKHE---AVSQLCSKTQASL 2410
Query: 1876 QEELEK-FDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDL 1934
QE LEK F EF+ W ++ + D L KL ++ + V + L
Sbjct: 2411 QESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKL 2470
Query: 1935 RYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLK 1994
+T G + ++ +S +Q ++ A + F++ +C L+
Sbjct: 2471 DAVTQEGQTLYAHLSK-------QIVSS-----IQEQITKANEEFQAFLKQCLKDKQALQ 2518
Query: 1995 DLVDKYQHYEDASCGLLAGLQACEATAS-KHLSEPIAVDPKNLQRQLEETKALQGQISSQ 2053
D + +ED L + E + ++L E P+ + ++ + + G++ +
Sbjct: 2519 DCASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEK-KNEVHKVEMFLGELLAA 2577
Query: 2054 QVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRS 2113
+ +++KL + + LL G + ++ +++L + E+ Q+ L
Sbjct: 2578 RESLDKLSQRGQ-LLSEEGH---GAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQVALQEH 2633
Query: 2114 LSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDI----AGRQSSIN 2169
++++ L M W+ ++ L ++ +D + K + QDI + +N
Sbjct: 2634 EALEEALQSMWFWVKAIQDRLA----CAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLN 2689
Query: 2170 AMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLS 2229
K ++ + +++ +Q +++ L +++ + +E + ++ +
Sbjct: 2690 MAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERK 2749
Query: 2230 EKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGL 2289
+L+ ++E+ Q + P + E + S E + H LH L+ +
Sbjct: 2750 NQLEQWMESVDQKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRE--- 2806
Query: 2290 PSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKV 2349
+ EKT + S K E+ + + +T +E++ + +VK ++
Sbjct: 2807 ------LYEKTEDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLD------ 2854
Query: 2350 PIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAV 2409
+ L K+ +WS + + + LI + A ++ V
Sbjct: 2855 -------AVHEFTDWLHSAKEELHRWSDMSGDSSATQKKLSKIKELIDSREIGASRLSRV 2907
Query: 2410 KSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIA-------EL 2462
+S + TA+ E + +++ D L++ ++ E
Sbjct: 2908 ESLAPEVKQNTTASGCELMHTE--MQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEF 2965
Query: 2463 NTKLSKLQKAQEESSAMMQ-WLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQ 2521
+ ++++L++A E+ SA+++ W Q++ K TD E V+ + + +A L++
Sbjct: 2966 SGQVAQLEQALEQFSALLKTWAQQLTLLEGK------NTDEEIVECWHKGQEILDA-LQK 3018
Query: 2522 NVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNL 2581
+ ++LK +L EL + D ++ +E N L + + + L
Sbjct: 3019 AEPRTEDLKSQLNELCRFSRDL------STYSGKVSGLIKEYNCLCLQASKGCQNKEQIL 3072
Query: 2582 TQ-FQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLT 2640
Q F+ +QWLV ++ + + + + ++T Q++Q L E + + +
Sbjct: 3073 QQRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMML 3132
Query: 2641 AAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLR 2700
+ G+ +LS +GI + ++ A + W + L + ++ ++ ++
Sbjct: 3133 SKGE-LLSTLLTKEKAKGI-QAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAE 3190
Query: 2701 SLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQI----KVAQALCED 2756
+ D LS + + S A ++ + Q + +EI + Q+ + AQ L E
Sbjct: 3191 PIQDWLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQLWEG 3250
Query: 2757 LSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWL 2816
+A + ++LS Q + K+ V L A +QF ++ Q W+
Sbjct: 3251 QAASKSFRHRVSQLSSQYLALSNLTKE-------KVSRLDRIVAEHNQFSLGIKELQDWM 3303
Query: 2817 -DTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSE 2875
D + HP S K VL+S + + + + GE++L T
Sbjct: 3304 TDAIHMLDSYCHPTSDK-SVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEG 3362
Query: 2876 KAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEI 2935
+Q QL ++K W + +++L+ +L K Y++ V W+D + NL E
Sbjct: 3363 IPTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNE- 3421
Query: 2936 KFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTA---NSLLSVCEIDKEVVTD---- 2988
E A+L+ + G +LLN +SLL E+ +T+
Sbjct: 3422 --------SERQHAELR----DKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTEHYVT 3469
Query: 2989 --ENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLG 3046
E + L ++ + E+ E + + +E+Q K + L +E+LD + L
Sbjct: 3470 QLELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLE 3529
Query: 3047 SQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEH 3106
A++++ T+ Q+ + + Q L L V S D L E++ Q+
Sbjct: 3530 GDAHTHE-TTLRDLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRAL--ESLRQDW 3586
Query: 3107 STLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKE 3166
++ E T+ Q + N +R M +F + D+ L + E + E
Sbjct: 3587 QAYQHRLSE------TRTQ-FNNVVNKLRLMEQKFQQVDEWLKTAEEKKWHEEVTAYRDE 3639
Query: 3167 TIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAR 3226
+ + E L S+ N+ C+ T L+ + ++ L ++ L
Sbjct: 3640 VEEVGARAQEILDESHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSL------- 3692
Query: 3227 EEQVEGTIKRLEEFY-SKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEE 3285
E+ E ++ ++Y S K F + K ++ ++T + ++L +V K+
Sbjct: 3693 -EESESSLSSYSDWYGSTHKNFKNVATKIDK---------VDTVMMGKKLKTLEVLLKD- 3741
Query: 3286 IEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEAL 3345
+E + G+ ++ + + + L ++ D + K L V + L++ L
Sbjct: 3742 MEKGHSLLKSAREKGERAVKYLEEGEAER-LRKEIHDHMEQLKELTSTVRKEHMTLEKGL 3800
Query: 3346 LHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEV 3405
F D ++L W+ + +E++ + P E KAQ+ + K LQ+ + + +V+
Sbjct: 3801 HLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKS 3860
Query: 3406 IKREGEKIATTAEPADKVKILKQLSLLDSRWEAL--LNKA----------ETRNRQLEGI 3453
++ +GE + E V + ++ L S ++ L + KA N Q++G
Sbjct: 3861 VREKGEALL---ELVQDVTLKDKIDQLQSDYQDLCSIGKAMMEEIAGFEDRLNNLQMKGD 3917
Query: 3454 SVVAQQFHETLEPLNEWLT-----TIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINH 3508
+++ Q L + + T + C LE ++ +H + +D +
Sbjct: 3918 TLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQC 3977
Query: 3509 NKHLHQA-----------VSIGQSLKVLS--------SREDKDMVQSKLDFSQVWYIEIQ 3549
L +S +++K + +R D++ S D S
Sbjct: 3978 QAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTA 4037
Query: 3550 EKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELR- 3608
+ + ++Q L A+ + E+ + +E+ L D + + ++ SEL
Sbjct: 4038 KDIQQTEQTIEQKLVQAQNLTQGWEEIKHLKSELWIYLQDA---DQQLQNMKRRHSELEL 4094
Query: 3609 ------VLQEDILLRKQNVDQALLNGL-ELLKQTTGDEVLIIQDKLEAIKARYKDITKLS 3661
V Q ++K QA +N + E + + T E ++ + ++ D+ + S
Sbjct: 4095 NIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQS 4154
Query: 3662 TDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKK 3721
++ E+ LQ R H C + +V +E + E L +A + + LKK
Sbjct: 4155 NNLCLQREEDLQRTRDYHD-----CMNVVEVFLEKFTTEWDNLARSDAESTAVHLEALKK 4209
Query: 3722 EA---KNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEID 3778
A + K ++ L + ++E + +E +++ + +R+ + D I +K++ +
Sbjct: 4210 LALALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQ-VS 4268
Query: 3779 AAILRSQQFDQAADAEL-SWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKD 3837
L Q+ EL W E + + D L E+ +
Sbjct: 4269 VTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICSELEAKQM 4328
Query: 3838 IIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFW 3897
++ L+K ++M E+Q ++K L + + + + +R L +A S QF
Sbjct: 4329 LLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQFL 4388
Query: 3898 ETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQ 3957
+ + + + I L + + +Q + + + + ++ + + G +
Sbjct: 4389 MAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQNEVTGLWAQGRE 4448
Query: 3958 LL-ELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLE 4016
L+ E++ E + K ++Y + + R L++ + F + D+ L+
Sbjct: 4449 LMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKEDFDKACHWLK 4508
Query: 4017 RIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKD 4076
+ ++ E ++ Q+++ +N+ + + L TL++ G+ ++ D
Sbjct: 4509 QADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQTILPSLNEVDHS 4568
Query: 4077 ISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIV-TIKDTQ-DF 4134
+ +KL+ + + I L +++ K+ + + LA K + + L ++ + + F
Sbjct: 4569 Y----LSEKLNALPRQFNVIVALAKDKFYKVQEAI-LARKEYASLIELTTQSLSELEAQF 4623
Query: 4135 IRDLEDPGIDPSVVK--QQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVK 4192
+R + P D +V + Q+ I +E+ GL E +D +N E + G+P +P
Sbjct: 4624 LRMSKVP-TDLAVEEALSLQDGCRAILDEVAGLGEAVD-ELNQKKEGFRSTGQPWQP--- 4678
Query: 4193 KSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGT 4252
+ L + + L + + R+ LE+ A +++ Q + + + + ++
Sbjct: 4679 DKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNE--- 4735
Query: 4253 DLETVKQQIEELKQFKSEAYQQQ---IEMERLNHQAELL---LKKVTEESDKHTVQDPLM 4306
ET+ + E+LK + S A Q I ++R+ E L L + E +H +Q
Sbjct: 4736 --ETLPAE-EKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQG 4792
Query: 4307 ELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKA 4366
ELKL+ ++ E + + ++ ++ FQ + L WL + LS + + +
Sbjct: 4793 ELKLLTSAIGETVTECESRMVQSI----DFQTEMSRSLDWLRRVKAELSGPVYLDLNLQD 4848
Query: 4367 IEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLE 4426
I+ E+ K + Q +V + + A++ + + +++L++ L L++ ++ E
Sbjct: 4849 IQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELDGDIQE 4908
Query: 4427 KTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHL-LASKPLGGLPETAKEQLNVHME 4485
R+ L Q + ++ + WL D + L LA L E+A+E L HME
Sbjct: 4909 ALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLD--VESAEENLKSHME 4966
Query: 4486 VCAAFEAKEETYKSLMQKGQQMLARCPK----SAETNIDQDINNLKEKWESVETKLNERK 4541
F + E+ + S +++ ++A + + +++Q + +L+ + + + +
Sbjct: 4967 ----FFSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQV 5022
Query: 4542 TKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQ----IDEHKVFAN 4597
L+ ++ + ++ I + E+ L S SL+ + + + EHK +
Sbjct: 5023 DLLQRCTAQWHDYQKAREEVIELMNDTEKKL---SEFSLLKTSSSHEAEEKLSEHKALVS 5079
Query: 4598 EVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDAR 4657
VNS E+I+ L++ + L+ + + +V RW ++ ++ + L+DA
Sbjct: 5080 VVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAV 5139
Query: 4658 KRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDT 4717
F+ K E +++ + L ++ T L H F L + S
Sbjct: 5140 DEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGM 5199
Query: 4718 TNRTGRSL---------KEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALL 4768
+ S+ E+ L + + D +++K T GK V+++ K E +
Sbjct: 5200 LRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKT-NGKLVKQELKDREMV- 5257
Query: 4769 FSGQFTDALQALIDWL-----YRVEPQLAEDQPVHGDIDLVMNLIDNHK---------AF 4814
+ ++ W+ Y P + D + ++ +++ NH+
Sbjct: 5258 -----ETQINSVKCWVQETKEYLGNPTIEIDAQLE-ELQILLTEATNHRQNIEKMAEEQK 5311
Query: 4815 QKELGKRT-----SSVQ----ALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSI 4865
+K LG T S+Q AL R+ I+ + K QELS + + +
Sbjct: 5312 EKYLGLYTILPSELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLT 5371
Query: 4866 SKQTRLEAALRQ-----------AEEFHSVVHALLEWLAEAEQTLRFHGVLPDD-EDALR 4913
+ T+L+A EE L+E A ++ L +G L +
Sbjct: 5372 TILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGKPLAKKIG 5431
Query: 4914 TLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWA 4973
L + H++ +++ E + ++LN+A + + + + + I WI + +AW
Sbjct: 5432 KLTELHQQTIRQAENRLSKLNQAASHLEE-----YNEMLELILKWIEKAKVLAHGTIAWN 5486
Query: 4974 KQHQQRLASALAGLIAKQEL-----LEALLAWLQWAETT-LTDKDKEVIPQ---EIEEVK 5024
Q R L + ++ LEA+ LQ+ + T+K + + + E EE++
Sbjct: 5487 SASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELR 5546
Query: 5025 ALIAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRK 5076
+I + ++ + D+ K K+ A Q+ + + GR K
Sbjct: 5547 QMI---KIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLK 5595
Score = 305 bits (782), Expect = 6e-82
Identities = 721/4187 (17%), Positives = 1586/4187 (37%), Gaps = 657/4187 (15%)
Query: 1350 ETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAE------------- 1396
E + + Q + L++ L+SE+E S +C +Y E
Sbjct: 1200 EVSSENEAQKQGDELAKLSSSFKALVTLLSEVEKMLSNFGDCVQYKEIVKNSLEELISGS 1259
Query: 1397 ----QYSATVKDYELQTMTYRAMVDSQQKS---PVKRRRMQSS-----------ADLIIQ 1438
+ + + D E + ++ QQK+ K+R +Q D +
Sbjct: 1260 KEVQEQAEKILDTENLFEAQQLLLHHQQKTKRISAKKRDVQQQIAQAQQGEGGLPDRGHE 1319
Query: 1439 EFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISK 1498
E L + L + + +L++ E E + E + + ++++S S
Sbjct: 1320 ELRKLESTLDGLERSRERQERRIQVTLRKWERFETNKETVVRYLFQTGSSHERFLSFSSL 1379
Query: 1499 TLKDAEKAGKPPFSKQ----KISSEEISTKKEQLSEALQTIQLF--LAKHGDKMTDEERN 1552
+E FSK+ + +E + + ++ Q QL AK + + +
Sbjct: 1380 ESLSSELEQTKEFSKRTESIAVQAENLVKEASEIPLGPQNKQLLQQQAKSIKEQVKKLED 1439
Query: 1553 ELEKQVKTLQ-------------ESYNLLFSESLKQLQESQTSG---DVKVEEKIVAERQ 1596
LE+ +KT++ E+ ++ +E K+L +TS D+++ + +
Sbjct: 1440 TLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQ--IKVTI 1497
Query: 1597 QEYKEKLQGICDLLTQTEN--RLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQA- 1653
QE + KL I L + ++ + + E+ I ++++Y + E + ++G+
Sbjct: 1498 QEIESKLSSIVGLEEEAQSFAQFVTTGESARIKAKLTQIRRYGEELREHAQCLEGTILGH 1557
Query: 1654 LAEVVKNTENFLKENGEKLSQEDKALIEQKLNEA---KIKCEQLNLKAEQSKKELDKVVT 1710
L++ K EN K EDK + K+ + K Q ++ Q+ + L +T
Sbjct: 1558 LSQQQKFEENLRKIQQSVSEFEDKLAVPIKICSSATETYKVLQEHMDLCQALESLSSAIT 1617
Query: 1711 -------------------TAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAG 1751
A++++ E + +++ +E +T +ENLL ++K+
Sbjct: 1618 AFSASARKVVNRDSCVQEAAALQQQYEDI--LRRAKERQTALENLLAHWQRLEKE----- 1670
Query: 1752 TKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQH 1811
+ T + G+ K++ E D + + + + Q ++A
Sbjct: 1671 ------LSSFLTWLERGEAKASSPEMD--------------ISADRVKVEGELQLIQALQ 1710
Query: 1812 EKIISQHQAVIIATQSAQVLLEKQGQY--LSPEEKEKLQKNMKELKVHYETALAESEKKM 1869
+++SQ A+ +++L K+ + S ++ + ++ ++++L + K++
Sbjct: 1711 NEVVSQ------ASFYSKLLQLKESLFSVASKDDVKMMKLHLEQLDERWRDLPQIINKRI 1764
Query: 1870 KLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVIS 1929
S+ E ++FD F W++ EL+ I L R K + +V S
Sbjct: 1765 NFLQSVVAEHQQFDELLLSFSVWIKLFLSELQT--TSEISIMDHQVALTRHKDHAAEVES 1822
Query: 1930 HKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVL 1989
KG+L+ ++ G+ K+ + ++ A D F+ V+
Sbjct: 1823 KKGELQ--SLQGHL-------------AKLGSLGRAEDLHLLQGKAEDCFQLFEEASQVV 1867
Query: 1990 GNN---LKDLVDKYQHYEDASCGLLAGL-QACEATASKHLSEPIAVDPKNLQRQLEETKA 2045
L L + Q + S G+L L Q EAT S + +E ++ K+L L+ KA
Sbjct: 1868 ERRQLALSHLAEFLQSHASLS-GILRQLRQTVEATNSMNKNESDLIE-KDLNDALQNAKA 1925
Query: 2046 LQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEK 2105
L+ S V+++ + A+ L S + + T D + G E + + + +
Sbjct: 1926 LE----SAAVSLDGILSKAQYHLKIGSS--EQRTSCRATADQLCGEVERIQNLLGTKQSE 1979
Query: 2106 LQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQ 2165
+ QD +E+L + ++E ++ ALQ + LE ++ +
Sbjct: 1980 ADALAVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHE 2039
Query: 2166 SSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELF 2225
+ + +K K+ + D + A + ++ L + + E + L + +
Sbjct: 2040 HELCWLKDKAKQIAQ-KDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREY 2098
Query: 2226 ENLSEKLQTFLETKTQAL-TEVDVPGKDVTELS-------------QYMQESTSEFLEHK 2271
+NL + LE + + T + KD +L Y Q+ F
Sbjct: 2099 QNLKSAVSKVLENASSVIVTRTTI--KDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKG 2156
Query: 2272 KHLEVLHSLLKEISSHG---LPSDKALVLEKTNNLSKKFKEMEDTIKEKK---EAVTSCQ 2325
KH L S LK+I S + +D ++K ++S+K +E D ++ + V S +
Sbjct: 2157 KH---LLSELKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTR 2213
Query: 2326 EQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEI-QK 2384
++++ + + + + + + + AE+L K E K + +L+ E+ K
Sbjct: 2214 DEIEGWS------NNCVPQMAENISNLDNHLRAEELLKEFESEVKNK---ALRLEELHSK 2264
Query: 2385 VNNSGISLCNLISAVTTP----------------AKAIAAVKSGGAVLNGEGTATNTEEF 2428
VN+ L L + TP AK I V + G + + +T E+F
Sbjct: 2265 VND----LKELTKNLETPPDLQFIEADLMQKLEHAKEITEV-AKGTLKDFTAQSTQVEKF 2319
Query: 2429 W--ANKGLTSIKKDMTDISHGYEDLGL-LLKDKIAELNTKLSKLQKAQEESSAMMQ---- 2481
T +++ + + + L +KD EL ++ S + QE +++ +
Sbjct: 2320 INDITTWFTKVEESLMNCAQNETCEALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHS 2379
Query: 2482 -WLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQE------------ 2528
L+ + + T + KTQ +S E +++ + QE
Sbjct: 2380 AELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLEKHFSESMQEFQEWFLGAKAAAKES 2439
Query: 2529 ---------LKDKLTEL----------------LEENPDTPEAPRWKQM-------LTEI 2556
L+ KL +L + + T A KQ+ +T+
Sbjct: 2440 SDRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQITKA 2499
Query: 2557 DSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWL--VEKELMVSVLGPLSIDPNM 2614
+ ++Q + + +Q L++ ++ L F+ +L W+ +E+ LG
Sbjct: 2500 NEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPE 2559
Query: 2615 LNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSL 2674
+ +V++ L E + ++L+ GQ +LS G G + QL Q +
Sbjct: 2560 KKNEVHKVEMFLGELLAARESLDKLSQRGQ-LLSEEGHGAGQEGRLCSQLLTSHQNLLRM 2618
Query: 2675 TGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQ 2734
T + C A+ + + L+S+ + + ++L+ + + D + ++L Q
Sbjct: 2619 TKEKLRSC---QVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQ 2675
Query: 2735 KMKQEIQQEKKQIKVAQALCEDLSAL-VKEEYLKAELSRQLEGILKSFKDVEQKAENHVQ 2793
+ + + + ++K+ A+ + AL + + + QLE + + + D+ + +
Sbjct: 2676 DIL--LMKGEGEVKLNMAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQS 2733
Query: 2794 HLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAK---------LDVLESLIKDHK 2844
L+S + + + + + W+++ +Q HP+ + LD L+S++ + +
Sbjct: 2734 TLESVISQWNDYVERKNQLEQWMES--VDQKIEHPLQPQPGLKEKFVLLDHLQSILSEAE 2791
Query: 2845 DFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKL 2904
D ++ L + IA+ L KT+ +++ +KT ++ KE+ K+
Sbjct: 2792 DHTRAL-------HRLIAKSRELYEKTE--DESFKDTAQEELKTQFNDIMTVAKEKMRKV 2842
Query: 2905 KESLEKALKYKEQVETLWPWIDKC-----------------QNNLEEIKFCLDPAE-GEN 2946
+E ++ L Y + V W+ Q L +IK +D E G +
Sbjct: 2843 EEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDSSATQKKLSKIKELIDSREIGAS 2902
Query: 2947 SIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHS 3006
+++++SL E+ Q N+ S CE+ + E ++L + +
Sbjct: 2903 RLSRVESLAPEVKQ------------NTTASGCEL----MHTEMQALRADWKQWEDSVFQ 2946
Query: 3007 KKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQ----- 3061
+ CLEN+ + ++ QL+ A EQ +Q LT+L+ +
Sbjct: 2947 TQSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQ-----QLTLLEGKNTDEE 3001
Query: 3062 --------QKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQV 3113
Q+ L AL+ + L L S+ S +V + +E++ L Q
Sbjct: 3002 IVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQA 3061
Query: 3114 DEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLK 3173
+ C E LQ + F +F L + + + + L+
Sbjct: 3062 SKGCQNKEQILQ---------QRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQ 3112
Query: 3174 KLEALMASNDNANKTCKMMLATEE------TSPDLVGIKRDLEALSKQCNKLLDRAQARE 3227
K++ ++ ++N MML+ E T GI+ + A + +E
Sbjct: 3113 KIQEFLSESENGQHKLNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKE 3172
Query: 3228 EQVEGTIKRLEEFYSKLKEFSILLQKAEE--HEESQGPVGMETETINQQLNMFKVFQKEE 3285
+E ++++F + L K E+ HE S + + QQ +
Sbjct: 3173 SALENLKIQMKDFEVSAEPIQDWLSKTEKMVHESSNRLYDLPAKRREQQK------LQSV 3226
Query: 3286 IEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEAL 3345
+E + + +N L + Q +++ H + +++++ L+ ++ ++L +
Sbjct: 3227 LEEIHCYEPQLNRLKEKAQQLWEGQAASKSFRHRVSQLSSQYLALSNLTKEKVSRLDRIV 3286
Query: 3346 LHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEV 3405
+F ++ L WM D ++ + P+++ V+ ++ + + L + +++ +++
Sbjct: 3287 AEHNQFSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKM 3346
Query: 3406 IKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLE 3465
I GE + P I +QL + W +LL+ QLEG + + +
Sbjct: 3347 IVTRGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVR 3406
Query: 3466 PLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVL 3525
+ W+ ++E L E + + + K L +++++++ L G +
Sbjct: 3407 QFSGWMDSMEANLNESERQHAELRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGM--- 3463
Query: 3526 SSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHD 3585
+ + Q +L Q Y IQE++ ++ + + + D WL + +
Sbjct: 3464 ---TEHYVTQLELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQE 3520
Query: 3586 KLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNG-LELLKQTTGDEVLIIQ 3644
KL + SV + ++ LR LQE L QALLN L + + +
Sbjct: 3521 KLDQYSVLEGDAH---THETTLRDLQE--LQVHCAEGQALLNSVLHTREDVIPSGIPQAE 3575
Query: 3645 DK-LEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQV 3703
D+ LE+++ ++ ++ + R + +++ WL E E +E
Sbjct: 3576 DRALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAE-EKKWHEEVT 3634
Query: 3704 LKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERY 3763
+E + R +E+ E+ N + +++S RY
Sbjct: 3635 AYRDEVEEVGARAQEILDESHVNSRMGCQATQLTS-----------------------RY 3671
Query: 3764 RLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQ 3823
+ + + ++++ ++ I ++ + + + W T K + ++ + D+ +
Sbjct: 3672 QALLLQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHK---NFKNVATKIDKVDTVMM 3728
Query: 3824 VQKTFTMEIL-----RHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQI 3878
+K T+E+L + ++ + G + + E E + ++K++ ++ +
Sbjct: 3729 GKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELTST 3788
Query: 3879 NSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLR 3938
+ ++ LE+ L +F + + L W+ E Q I+ P +E + Q +++ L+
Sbjct: 3789 VRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQ 3848
Query: 3939 ELIAEHKPHIDKMNKTGPQLLEL---------------------SPGE-------GF--- 3967
+ + H+P + + + G LLEL S G+ GF
Sbjct: 3849 QTVLSHEPSVKSVREKGEALLELVQDVTLKDKIDQLQSDYQDLCSIGKAMMEEIAGFEDR 3908
Query: 3968 --SIQEK-----YVAADTLYSQIKEDV------------------KKRAVALDEAISQST 4002
++Q K AD L +++K++V ++ +L+ + +
Sbjct: 3909 LNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHV 3968
Query: 4003 QFHDKIDQI---LESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETL 4059
D + Q L +++ +E QPP AE I + K+ E+ + + L
Sbjct: 3969 SRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEA------IKQVKHFRALQEQARTYLDLL 4022
Query: 4060 KQRGEEMIARSGGTDKDI--SAKAVQDKLDQMVFI---WENIHTLVEEREAKLLDVMELA 4114
+ A T KDI + + ++ KL Q + WE I L E L D +
Sbjct: 4023 CSMCDLSNASVKTTAKDIQQTEQTIEQKLVQAQNLTQGWEEIKHLKSELWIYLQDADQQL 4082
Query: 4115 EKFWCDHMSLIVTI-----KDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEEL 4169
+ H L + I +DF++ L+ +Q + TI E+++ L ++
Sbjct: 4083 QNMKRRHSELELNIAQNMVSQVKDFVKKLQ----------SKQASVNTIIEKVNKLTKK- 4131
Query: 4170 DIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDG 4229
++ K I+ LN W L + + + EE +Q Y D
Sbjct: 4132 -----------------EESPEHKEINHLNDQWLDLCRQSNNLCLQREEDLQRTRDYHDC 4174
Query: 4230 LQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLL 4289
+ V +++ + +++ +D E+ +E LK+ +++ +E L Q + ++
Sbjct: 4175 MNVVEVFLEKFTTEWDNLA--RSDAESTAVHLEALKKLALALQERKYAIEDLKDQKQKMI 4232
Query: 4290 KKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTH 4349
+ + + DK V++ L+ W LE+ I + L L Q EL+ W
Sbjct: 4233 EHLNLD-DKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEE 4291
Query: 4350 TEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASN 4409
+ ++E P + L H + +++ A Q ++++ K + ++ E
Sbjct: 4292 QQPNIAEALKQSPPPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNERQV 4351
Query: 4410 LQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPL 4469
+Q L + + QR++ L+ AL + F + + ER ++ + +
Sbjct: 4352 IQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHI 4411
Query: 4470 GGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEK 4529
LP+ +Q+ A+ + + L +G++++ + ++ + + L+
Sbjct: 4412 CLLPDDVSKQVKTCKSAQASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSV 4471
Query: 4530 WESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLIL----DTV 4585
++SV K + R +LE+ L F +WL QA+ + + P + L +
Sbjct: 4472 YDSVLQKCSHRLQELEKNLVSRKHFKEDFDKACHWLKQAD----IVTFPEINLMNESSEL 4527
Query: 4586 LFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQR 4645
Q+ +++ + + ++ L +TG + + D + L ++ ++ +V
Sbjct: 4528 HTQLAKYQNILEQSPEYENLLLTLQRTGQTILPSLNEVDHSYLSEKLNALPRQFNVIVAL 4587
Query: 4646 LVERGRSLDD---ARKRAKQFHEAWSKLMEWLE---------ESEKSLDSELEIANDPDK 4693
++ + + ARK E ++ + LE ++ +++ L + +
Sbjct: 4588 AKDKFYKVQEAILARKEYASLIELTTQSLSELEAQFLRMSKVPTDLAVEEALSLQDGCRA 4647
Query: 4694 IKTQLAQHKEFQKSLGAKHSVYDTT----------------NRTGRSLKEKTSLADDNL- 4736
I ++A E L K + +T +R R +++ SL +D
Sbjct: 4648 ILDEVAGLGEAVDELNQKKEGFRSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTS 4707
Query: 4737 ----------KLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDA---LQALIDW 4783
+L+ L ++++ + +++ + KL+ +G D+ L+ +
Sbjct: 4708 AYQEHEKMCQQLERQLKSVKEEQSKVNEETLPAEEKLKMYHSLAGSLQDSGIVLKRVTIH 4767
Query: 4784 LYRVEPQL---------AEDQPVHGDIDLVMNLIDNHKA-----------FQKELGKRTS 4823
L + P L + Q G++ L+ + I FQ E+ +
Sbjct: 4768 LEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSR--- 4824
Query: 4824 SVQALKRSAREL---------IEGSRDDSSWVKVQMQELSTRWETVCALSISKQTR---- 4870
S+ L+R EL ++ +++ +++ +E+ + + ALS ++ +
Sbjct: 4825 SLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKA 4884
Query: 4871 -------LEAALRQAEE-------------------------FHSVVHALLEWLAEAEQT 4898
LE +L + E ++ V A +WL +A++
Sbjct: 4885 KELISADLEHSLAELSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQEL 4944
Query: 4899 LRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHW 4958
L+ G D E A L H EF ++ + L + ++ T+ + P
Sbjct: 4945 LQLAGNGLDVESAEENL-KSHMEFFSTEDQFHSNLEELHSLVATLDPLIKPTG------- 4996
Query: 4959 ITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQ 5018
+ E+ +A + QR++ A+ +LL+ A QW + K +E + +
Sbjct: 4997 ----KEDLEQKVASLELRSQRMSRDSG---AQVDLLQRCTA--QWHD---YQKAREEVIE 5044
Query: 5019 EIEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRF 5078
+ + + ++E F T + ++ +K + +S I L++
Sbjct: 5045 LMNDTEKKLSE---FSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEE-------- 5093
Query: 5079 PASSLYPSGSQTQIETKNPRVNLLVSKWQQVWLLALERRRKLNDALD 5125
AS L +G+ T + + + +W ++ +A ++ + L DA+D
Sbjct: 5094 KASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVD 5140
Score = 295 bits (754), Expect = 1e-78
Identities = 742/3922 (18%), Positives = 1500/3922 (38%), Gaps = 500/3922 (12%)
Query: 1148 EQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTY 1207
E+EK K E + DL S A S ++ L + ++YS Y
Sbjct: 4877 EKEKFTKAKELISADLE---------HSLAELSELDGDIQEALRTRQATLTEIYSQCQRY 4927
Query: 1208 IDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQ 1267
+ N L++ A+ L++L L E A ENL S ++ + +E
Sbjct: 4928 YQVFQAANDWLED---AQELLQLAGNGLDVESAE-------ENLKSHMEFFSTE-----D 4972
Query: 1268 VFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEG 1327
FH+ +EL A D + K + DL+ +K L R Q + ++ L+
Sbjct: 4973 QFHSNLEELHSLVATLDPLIKPTGKEDLE-----QKVASLELRSQRMSRDSGAQVDLLQ- 5026
Query: 1328 IGKSLKYYRDTYHPLDDWIQQVETTQRKIQEN---QPENSKTLATQLNQQKMLVSEIEMK 1384
+ + D ++ I+ + T++K+ E + +S +L++ K LVS +
Sbjct: 5027 --RCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSF 5084
Query: 1385 QSKMDECQKYAEQYSATVKDYELQTMT------------YRAMVDSQQKS---------- 1422
K+ ++ A Q T D T++ RA+ Q+K
Sbjct: 5085 HEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTG 5144
Query: 1423 -------------------PVKRRRMQSSADLI-IQEFMD-----LRTRYTALVTLMTQY 1457
P S A+L+ + E+ D L + +AL L Q
Sbjct: 5145 FNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQT 5204
Query: 1458 IKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSN----ISKTLKDAEKAGKPPFSK 1513
+ D EE L +E ++ +Q+ V + + LKD E S
Sbjct: 5205 LSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSV 5264
Query: 1514 Q---KISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFS 1570
+ + + E + ++ L+ +Q+ L + R +EK + +E Y L++
Sbjct: 5265 KCWVQETKEYLGNPTIEIDAQLEELQILLTE-----ATNHRQNIEKMAEEQKEKYLGLYT 5319
Query: 1571 --ESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGD 1628
S LQ ++ + D+K+ ++I Q + KE Q ++ ++ + Q + D
Sbjct: 5320 ILPSELSLQLAEVALDLKIRDQI----QDKIKEVEQ------SKATSQELSRQIQKLAKD 5369
Query: 1629 GTVELKKYQSK----------QEELQKDMQGSAQALAEVVKNTENFLKENGE-------- 1670
T L K ++K Q+ L +++ G L E+ + FL++NG+
Sbjct: 5370 LTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGKPLAKK 5429
Query: 1671 --KLSQEDKALIEQ------KLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAA 1722
KL++ + I Q KLN+A E+ N E K ++K A T +
Sbjct: 5430 IGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLA--HGTIAWNS 5487
Query: 1723 VKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNG 1782
QL E + LL+ +D + E A T+ Q + + + +G E E
Sbjct: 5488 ASQLREQYILHQTLLEESKEIDSELE-AMTEKLQYLTSVYCTEKMSQQVAELGRETEELR 5546
Query: 1783 NLLETDVDGQVGTTQENLNQQYQKVKAQHEKI---ISQHQAVIIATQSAQVLLEKQGQYL 1839
+++ + ++ + +K +A+ +K+ + Q QA + + + ++ L++Q +
Sbjct: 5547 QMIKIRLQNL-----QDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSHR 5601
Query: 1840 SP--EEKEKLQKNMKELKVHYET----------------ALAESEKKMKLTHSLQEELEK 1881
E E L+ ++ +++ AL E+ +L H+ ++
Sbjct: 5602 QHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNI 5661
Query: 1882 FDADYTEFEHWLQQ----------SEQELENLEAGADDINGLMTKLKRQ-------KSFS 1924
A ++E + Q+ + +E+E+ +I L ++ R K +
Sbjct: 5662 MQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQ 5721
Query: 1925 EDVISHKGDLRYITISGNR---------VLEAAKSCSKRDGGKVDTSATHREVQRKLDHA 1975
E + S + +T+ V A+ DG + T + H V
Sbjct: 5722 EQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSV------- 5774
Query: 1976 TDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKN 2035
+C+ L + + + + E+ + ++ AC + + P+A +
Sbjct: 5775 ---VMMTAGRCHTLLSPVTE-----ESGEEGTNSEISSPPACRSPS------PVANTDAS 5820
Query: 2036 LQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDL 2095
+ + + +AL + A +A G L P+ L D+ +E L
Sbjct: 5821 VNQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPG-LEPSAT---AKLGDLQRSWETL 5876
Query: 2096 SKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQ---GQVPLNSTAL-QDII 2151
++E+ L L R QD L + M +E L E G+ P + A Q ++
Sbjct: 5877 KNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPESQMAEHQALM 5936
Query: 2152 SKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKET 2211
+ +ML+ +I QSS+ E V + E DP+ +LQ+ + L+ R S K
Sbjct: 5937 DEILMLQDEINELQSSL--AEELVSESCEA-DPAEQLALQSTLTVLAERMSTIRMKASGK 5993
Query: 2212 LAKMEELKTKVELFENLSEK-----------LQTFLETKTQALTEVDVPGKDVTELSQYM 2260
+EE K +L E E+ L ++L + L P K+ ++ +
Sbjct: 5994 RQLLEE-KLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEAQL 6052
Query: 2261 QESTSEFLEHKKHLEVLHSLLKEISSHG---LPSDKALVLEKTNNLSKKFKEMEDTIKEK 2317
+ + +E ++ + L E+S H L KA ++ L+ K + ++ ++ E
Sbjct: 6053 MDCQNMLVEIEQKVVAL----SELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLEL 6108
Query: 2318 KEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFG------AEDLGKSLEDTKKL 2371
+ A+ +QL+ + +S + T + P VQ + SL+ K+L
Sbjct: 6109 QRALHD--KQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQQQKEL 6166
Query: 2372 QEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWAN 2431
+++ + + ++ V + G + SA T A L EG ++ E+
Sbjct: 6167 EQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAEDQMRM 6226
Query: 2432 KGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKA--QEESSAMMQWLQKMNKT 2489
K +E L E +TK LQ QE+ + ++
Sbjct: 6227 K---------------WESLH-------QEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSG 6264
Query: 2490 ATKWQQTPAPTDTEAVKTQVEQ-NKSFE-------AELKQNVNKVQELKDKLTELLEENP 2541
++ D AV + ++ N++FE +Q+++ Q+L D ++
Sbjct: 6265 VPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLD 6324
Query: 2542 DTPEAPRWKQMLTEIDSKWQELNQ--LTIDRQQKLEESSNNLTQF-QTVEAQLKQWLVEK 2598
D E L +++ NQ L D ++ EE N F Q V +
Sbjct: 6325 DVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIE 6384
Query: 2599 ELMVSVLGPLSIDPNMLNTQRQQVQ-------------------------ILLQEFAT-- 2631
+ + +LG LS+ +++N + Q++ I+LQ+ A
Sbjct: 6385 DTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQKLANVF 6444
Query: 2632 RKPQYEQLTAAGQ----------GI--LSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLS 2679
+P EQ+ A Q GI L R G+ + ++L+ + +D L +
Sbjct: 6445 EQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSKLQDMYDELMMIIG 6504
Query: 2680 DRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQE 2739
R ++Q + +QY+ L+ L+D L K++ + QQL K K+
Sbjct: 6505 SRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQL--LDKHKEY 6562
Query: 2740 IQQEKKQIKVAQALCEDLS--ALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQS 2797
Q + + + + L + A+ KE EL Q +LK +A L+
Sbjct: 6563 FQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLK-------RAHKRGVELEY 6615
Query: 2798 ACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMY 2857
+ + ++ L+ + + D L I ++ +L
Sbjct: 6616 ILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKL 6675
Query: 2858 EKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQ 2917
+ + +G+ LL+ S+ L+ QLN + W + ++ + ++L+ L+ +Y+ +
Sbjct: 6676 YQVLDDGKRLLISISCSD---LESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSE 6732
Query: 2918 VETLWPWIDKCQNNLE--EIKFCLDPAEGE---NSIAKLKSLQKEMDQHFGMVELLNNTA 2972
L W+ ++ LE + P E E + + KE+D + + +T
Sbjct: 6733 SADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTG 6792
Query: 2973 NSLLSVCEIDKEVVTDENK-------SLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVS 3025
N LL + ++D + E L+ + V E+LH + ++ + + + +S
Sbjct: 6793 NQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQ--MDKLPSRHAISEVMS 6850
Query: 3026 KESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVE 3085
S + K++ +I +S+G +A ++YL + + + + VD + + +
Sbjct: 6851 WISLMENVIQKDEDNIKNSIGYKAI-HEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQ 6909
Query: 3086 ASDSKGT--SDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAE 3143
+SK + +D Q+ + + L V EK LE L+ ++N ++ + + F
Sbjct: 6910 DVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFET 6969
Query: 3144 FDDELDSMAPVGRDAET------LQKQKETIKAFLKKLEAL------MASNDNANKTCKM 3191
+ L +G A Q ++ IKA K++E + + N + + +
Sbjct: 6970 QEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIV 7029
Query: 3192 MLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILL 3251
M E + + L +LD+ + + + L E L F +L
Sbjct: 7030 MSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLT 7089
Query: 3252 QKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKST 3311
E + Q++ + Q +++E + Q + L++
Sbjct: 7090 GSLE--------------AVQVQVDNLQNLQ-DDLEKQERSLQKFGSITNQLLKECHPPV 7134
Query: 3312 STQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVD----TEE 3367
T+ L + L +VN RW L +++A++ + L R++D + S + T E
Sbjct: 7135 -TETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNE 7193
Query: 3368 LVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTV-------EVIKREGEKIATTAEPA 3420
L+ V IQ+ L + L K ++ E +K++ + A +A +
Sbjct: 7194 LLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQS 7253
Query: 3421 DKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVN 3480
D++ + + L L E L K +T L+ + + F ++LE L W+ E+ L
Sbjct: 7254 DQLSLSQHLCAL----EQALCKQQT---SLQAGVLDYETFAKSLEALEAWIVEAEEILQG 7306
Query: 3481 CEPI-GTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLD 3539
+P + S ++E++ + K + L + +G L L+ +E K M +
Sbjct: 7307 QDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLP-LNDKEIKRMQ----N 7361
Query: 3540 FSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEG 3599
++ W + I ++ R LQ L + F E M +L + KL+ +Y +
Sbjct: 7362 LNRHWSL-ISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNY--QH 7418
Query: 3600 LWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITK 3659
L +QQ + Q ++ R+Q + +++G LL+Q D+ KL + +++ + +
Sbjct: 7419 LLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIR 7478
Query: 3660 LSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKEL 3719
+ ++ ++ +R E+L WL VEV L QA+ E+
Sbjct: 7479 RAQQRRGIIDSQIRQWQRYREMAEKLRKWL--VEVSYLPMSGLGSVPIPLQQARTLFDEV 7536
Query: 3720 KKEAK---NNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEE 3776
+ + K + E LL A L+ +AE E+++ S + ++ ++
Sbjct: 7537 QFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKK 7596
Query: 3777 IDAAILRSQQFDQAADAELSWITETEKKL-MSLGDIRLEQDQTSAQLQVQKTFTMEILRH 3835
+ + ++ ++ L + +KKL SL D ++ A+ K +
Sbjct: 7597 LAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPD---HHEELHAEQMRCKELENAVGSW 7653
Query: 3836 KDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQ 3895
D + L + S ++ + ++++ + + ++ +C S R Q+ +
Sbjct: 7654 TDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAV 7713
Query: 3896 FWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTG 3955
F E +EL WLT+ +S +SQ +E E + + ++++++ + E+K + +M G
Sbjct: 7714 FSEKNKELCEWLTQMESKVSQNGDILIE-EMIEKLKKDYQEEIAIAQENKIQLQQM---G 7769
Query: 3956 PQLLELS-PGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILES 4014
+L + S + I+ K + + + + + R L E + Q + +
Sbjct: 7770 ERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTW 7829
Query: 4015 LERIVERLRQPPSI-SAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGT 4073
L I L +P S E+I+ +++E + + D+EK ++ E ++
Sbjct: 7830 LAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDAC 7889
Query: 4074 DKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQD 4133
D ++Q + W NI + ER K+ + L +KF D+ +K ++
Sbjct: 7890 ATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSER 7949
Query: 4134 FIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKK 4193
G+ +V K++ + E + ++ +L+++ L +K+
Sbjct: 7950 TAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQ 8009
Query: 4194 SIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTD 4253
+ E N WD+L K + +L+ + +++ ++ W+ +L ++
Sbjct: 8010 MVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSEC 8069
Query: 4254 LETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWD 4313
V+ +I++LK F+ E ++E++ Q E L++K +E D +++ L EL+
Sbjct: 8070 --DVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEK-SEPLDAAIIEEELDELRRYCQ 8126
Query: 4314 SL-------------------EERIINRQHKLE--GALLALGQFQHALDELLAWLTHTEG 4352
+ E + +R+ +LE AL L + D LL+ +
Sbjct: 8127 EVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNL 8186
Query: 4353 LLSEQKPV-----GGDPKA----IEIELAKHHVLQNDVLAHQS-TVEAVNKAGND----L 4398
LS +P+ G D A I +E + L D+ + S + + ++ G D
Sbjct: 8187 SLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFY 8246
Query: 4399 IESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTD 4458
+ + G + E + +N ++ T L+ +RQ ++D + +
Sbjct: 8247 LRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQ---LGKALDDSRFQIQQ 8303
Query: 4459 TERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETN 4518
TE + + P G +T+ + +M++ + ++ K L K ++ P +
Sbjct: 8304 TENIIRSKTPTGPELDTSYKG---YMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLH 8360
Query: 4519 -IDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASR 4577
+ + ++WE ++ + ++ ++++ L +F++ L WL E+ L R
Sbjct: 8361 STETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQR 8420
Query: 4578 PSLILD--TVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISV 4635
L D T+ QI + K V+ + I+ ++ K+ L ++ L +
Sbjct: 8421 LELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDL-QDRLSQM 8479
Query: 4636 QSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKS--------------- 4680
RW++V L E L DA + + FHE L+ LE ++
Sbjct: 8480 NGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEI 8539
Query: 4681 ---------------LDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSL 4725
L+S+L +A+ D + QL + E L AK V+ NR L
Sbjct: 8540 LQDHHKQLMQIKHELLESQLRVASLQD-MSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLL 8598
Query: 4726 KEKTSLADDNLKLDDMLSELRD 4747
KE + + KL D+ S +D
Sbjct: 8599 KEVSRHIKELEKLLDVSSSQQD 8620
Score = 294 bits (752), Expect = 2e-78
Identities = 839/4655 (18%), Positives = 1777/4655 (38%), Gaps = 599/4655 (12%)
Query: 612 EPNSLQTLKLMQIRKPLLKSSLLDQNL---TEEEINMKFVQDLLNWVDEMQVQL---DRT 665
+PN + LK Q P + +LL +L +E E ++ L+ D + L +R
Sbjct: 4293 QPNIAEALK--QSPPPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNERQ 4350
Query: 666 EWGSDLPSVESHL--------ENHKNVHRAIEEFESSLKEA--KISEIQMTAPLKLTYAE 715
L +SH+ + K +++A+ E L S+IQ K+ + E
Sbjct: 4351 VIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHER-KIMFRE 4409
Query: 716 KLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIA 775
+ L +K + T ++ + L T N EV W++
Sbjct: 4410 HICLLPDDVSKQVKTCKSAQASLKTYQN------------------EVTGLWAQGR---- 4447
Query: 776 RKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQ 835
ELM+E+ ++E++ E+ +L +Q+ + +LQ C
Sbjct: 4448 -------ELMKEVTEQEKS-----EVLGKL---------------QELQSVYDSVLQKCS 4480
Query: 836 CVEQHIKENTAYFEFFN-DAKEATDYLRNLKDAIQRKYSC-DRSSSIH----KLEDLVQE 889
Q +++N + F D +A +L+ + + + SS +H K ++++++
Sbjct: 4481 HRLQELEKNLVSRKHFKEDFDKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQ 4540
Query: 890 SMEEKEELLQYKSTIANLMGKAKTIIQ--LKPRNSDCPLKTSIPIKAICDYRQIEITIYK 947
S E + LL + T ++ + L + + P + ++ + D YK
Sbjct: 4541 SPEYENLLLTLQRTGQTILPSLNEVDHSYLSEKLNALPRQFNVIVALAKD------KFYK 4594
Query: 948 DDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWH 1007
E +LA + + ++ + + +E + + P DLA + L+L
Sbjct: 4595 VQEAILARKEYASLIELTTQSLSELEAQFLRMSKVP-----TDLA------VEEALSLQD 4643
Query: 1008 ESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQ 1067
+ V ++E+++ + ++ + P + +++ L R L+ E +
Sbjct: 4644 GCRAILDEVAGLGEAVDELNQKKEGFRSTGQPWQPDKMLHLVT-LYHR----LKRQTEQR 4698
Query: 1068 VFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLE-NCEDRL 1126
V D T +E Q + LKS + E+ + + L E + L + +D
Sbjct: 4699 VSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNEETLPAEEKLKMYHSLAGSLQDSG 4758
Query: 1127 IRQIRTPLERDDLHESVFRITEQ------EKLKKELERLKDDLGTITNKCEEFFSQAAAS 1180
I R + +DL + + + + + EL+ L +G +CE Q+
Sbjct: 4759 IVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQSI-- 4816
Query: 1181 SSVPTLRSELNVVLQNMNQVYSMSS--TYID--------KLKTVNLVLKNTQAAEALVKL 1230
++E++ L + +V + S Y+D +++ + + + Q++ ++
Sbjct: 4817 ----DFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNA 4872
Query: 1231 YETKLCEE-----EAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDE 1285
K E+ E + AD +E+ ++ L + ++ E AL I +
Sbjct: 4873 LSHKEKEKFTKAKELISAD---LEHSLAELSELDGDIQE------ALRTRQATLTEIYSQ 4923
Query: 1286 MFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDW 1345
+ Y+ DW ++ + L Q+ D+E ++LK + + + D +
Sbjct: 4924 CQRYYQVFQAANDWLEDAQELL---------QLAGNGLDVESAEENLKSHMEFFSTEDQF 4974
Query: 1346 IQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDY 1405
+E + P T L Q+ V+ +E++ +M
Sbjct: 4975 HSNLEELHSLVATLDPLIKPTGKEDLEQK---VASLELRSQRMSRDSG------------ 5019
Query: 1406 ELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSL 1465
A VD Q+ + Q + + +I+ D + + L T A + L
Sbjct: 5020 --------AQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKL 5071
Query: 1466 KRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKK 1525
E K+L EK L++ S + KT DA KA S + +
Sbjct: 5072 S----EHKALVSVVNSFHEKIVALEEKASQLEKTGNDASKA------TLSRSMTTVWQRW 5121
Query: 1526 EQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDV 1585
+L Q + L D+ T N+++K + + + + L S ++ +++ +
Sbjct: 5122 TRLRAVAQDQEKILEDAVDEWTGFN-NKVKKATEMIDQLQDKLPGSSAEKASKAELLTLL 5180
Query: 1586 KVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQK 1645
+ + V E +Q+ Q+ ++ Q M+ DG ++ L +
Sbjct: 5181 EYHDTFVLELEQQ-------------QSALGMLRQQTLSMLQDGAAPTP---GEEPPLMQ 5224
Query: 1646 DMQGSAQALAEVVKNTENFLKENGEKLSQE--DKALIEQKLNEAKIKCEQLNLKAEQSKK 1703
++ A+ + N + +K NG+ + QE D+ ++E ++N K ++
Sbjct: 5225 EIT----AMQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQETKEYLGNPTI 5280
Query: 1704 ELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQV--IEQN 1761
E+D QLEE + + + N++K +E K+ + I +
Sbjct: 5281 EIDA-----------------QLEELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILPS 5323
Query: 1762 GTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAV 1821
Q + + D++ + E + Q T + L++Q QK+ I+++ +A
Sbjct: 5324 ELSLQLAEVALDLKIRDQIQDKIKEVE---QSKATSQELSRQIQKLAKDLTTILTKLKA- 5379
Query: 1822 IIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMK-LTHSLQEELE 1880
++ V+ K Q + EE + + EL + L ++ + K L + + E
Sbjct: 5380 ----KTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTE 5435
Query: 1881 KFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKG--DLRYIT 1938
+ E+ L + Q +LE + + ++ +++ K + I+ LR
Sbjct: 5436 LHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQY 5495
Query: 1939 ISGNRVLEAAKSCSKRDGGKVD-------TSATHREVQR--KLDHATDRFRSLYSKCNVL 1989
I +LE +K + T + Q+ +L T+ R + +
Sbjct: 5496 ILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIK---IR 5552
Query: 1990 GNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQ--LEETKALQ 2047
NL+D + +E L A L+ +AT + +++ + RQ L E ++L+
Sbjct: 5553 LQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEMESLK 5612
Query: 2048 GQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQ 2107
++ + Q+ L+ +V+ A L A +Q E+ S+ + ++
Sbjct: 5613 PKVQAVQLCQSALRIPEDVV--ASLPLCHAALRLQ----------EEASRLQHTAIQQCN 5660
Query: 2108 ITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDI---ISKNIMLEQDIAGR 2164
I + + EM +E + +E P+ ++ +Q++ IS++ L Q I G
Sbjct: 5661 IMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGY 5720
Query: 2165 QSSINAMNEKVKKFMETTDPST-------ASSLQAKMKDLSARFSEASHKHKE----TLA 2213
Q I ++N K K +T L +DL H T
Sbjct: 5721 QEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAG 5780
Query: 2214 KMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVT---ELSQYMQESTSEFLEH 2270
+ L + V E+ E + + + + V D + +++ Y S
Sbjct: 5781 RCHTLLSPVTE-ESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTD 5839
Query: 2271 KKHLEVLHSLLKEISSHGL-PSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLD 2329
+ S +E GL PS A K +L + ++ +++ I EK+ + E+
Sbjct: 5840 AAKIHPSTSASQEFYEPGLEPSATA----KLGDLQRSWETLKNVISEKQRTLYEALERQQ 5895
Query: 2330 AFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSG 2389
+Q ++S+ + ++ K+ P G + E + E L+ EI ++ +S
Sbjct: 5896 KYQDSLQSISTKMEAIELKLS-ESPEPGRSPESQMAEHQALMDEILMLQD-EINELQSSL 5953
Query: 2390 ISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYE 2449
S PA+ +A + LT + + M+ I
Sbjct: 5954 AEELVSESCEADPAEQLALQST----------------------LTVLAERMSTIRMKAS 5991
Query: 2450 DLGLLLKDKI---AELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPA-PTDTEAV 2505
LL++K+ E + LQ+ + E+ + WL T P P D EA
Sbjct: 5992 GKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEA- 6050
Query: 2506 KTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENP--DTPEAPRWKQMLTEIDSKWQEL 2563
Q+ ++ E++Q V + EL LL E EA + L + EL
Sbjct: 6051 --QLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLEL 6108
Query: 2564 NQLTIDRQ-------QKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLN 2616
+ D+Q Q+ EES +LT Q+ Q +WL + + S+
Sbjct: 6109 QRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQ--EWLAQARTTWTQQRQSSL------ 6160
Query: 2617 TQRQQVQILLQEFATRKPQYEQLTAAGQGILSR---------PGEDPSLR----GIVKEQ 2663
QQ + L QE A +K + + G+ IL + GE P + G+ E+
Sbjct: 6161 ---QQQKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGEK 6217
Query: 2664 LAAVTQ---KWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDL-----DNKLSS 2715
+A Q KW+SL + S + + Q +++ Q Q L + LS + D
Sbjct: 6218 SSAEDQMRMKWESLHQEFSTKQKLL-QNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQD 6276
Query: 2716 SLAVSTHPDAMNQQLETAQKM-----KQEIQQEKKQ---IKVAQALCEDL-------SAL 2760
AV++ D +NQ E +Q I E+K + +D+ +AL
Sbjct: 6277 KSAVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATAL 6336
Query: 2761 VKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWL---- 2816
+ EE ++++ + K K++ ++ + + A + + + D L
Sbjct: 6337 LPEETETCLFNQEI--LAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRL 6394
Query: 2817 -----------DTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGE 2865
KE + L VL + + D+K L ++++E+ +AE
Sbjct: 6395 SLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYI--ILQKLANVFEQPVAEQI 6452
Query: 2866 NLL----------------LKTQGS----EKAALQLQLNTIKTNWDTFNKQVKERENKLK 2905
+ LK +G E+ ++Q +L+ ++ +D + R + L
Sbjct: 6453 EAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQ-ELSKLQDMYDELMMIIGSRRSGLN 6511
Query: 2906 ESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMV 2965
++L +Y+ ++ L ++ Q + + + ++ E I +L KE Q
Sbjct: 6512 QNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEE--IQQLLDKHKEYFQGLESH 6569
Query: 2966 ELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVS 3025
+L T + + KE T + L+ + V ++ H + LE + + + E
Sbjct: 6570 MILTETLFRKIISFAVQKE--TQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQ 6627
Query: 3026 KESKRQLQCAKEQLDIHDSLGSQAYSNKYL----TMLQTQQKSLQALKHQVDLAKRLAQD 3081
+E RQL+ + + S+G + L T+ Q + SL + ++ +
Sbjct: 6628 QELSRQLEVVESSIP---SVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKR 6684
Query: 3082 LVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQF 3141
L++ S SD+ Q+ + + + + ++ ++ LET L+ +Q+ ++
Sbjct: 6685 LLISIS----CSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWL 6740
Query: 3142 AEFDDELD----SMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEE 3197
D L+ V ++ E ++ F K+++A + + T +L ++
Sbjct: 6741 QSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKK 6800
Query: 3198 TSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGT-IKRLEEFY--SKLKEFSILLQKA 3254
D ++ +L + Q LL A +E++ + +L + S++ + L++
Sbjct: 6801 V--DTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENV 6858
Query: 3255 EEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQ 3314
+ +E + + I++ L +K F+ + + KQ V+++ Q ++Q +++ ++
Sbjct: 6859 IQKDEDNIKNSIGYKAIHEYLQKYKGFKID----INCKQLTVDFVNQSVLQISSQDVESK 6914
Query: 3315 GLE-----HDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELV 3369
+ L +N W+ L V ++ L+ L +++ ++ L +W +T+E
Sbjct: 6915 RSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWF-ETQEKR 6973
Query: 3370 ANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQL 3429
Q+ + V+ +++ + L+ L+ ++ VE I++ G + + ++ L
Sbjct: 6974 LKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMSTL 7033
Query: 3430 SLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQAS 3489
L W L + L+ + + +N +L L +
Sbjct: 7034 RELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLE 7093
Query: 3490 KLEEQIAQHKALEDDIINHNKHLHQAVSI-GQSLKVLSSREDKDMVQSKLDFSQVW---Y 3545
++ Q+ + L+DD+ + L + SI Q LK + + + + + W
Sbjct: 7094 AVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLL 7153
Query: 3546 IEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQS 3605
EI E+ S LLQ + + S + Q+ T L K +
Sbjct: 7154 EEIAEQLQSSKALLQL--------------WQRYKDYSKQCASTVQQQEDRTNELLKAAT 7199
Query: 3606 ELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVA 3665
+ +++ Q+ + LL GL +K D + + + E +K + + A
Sbjct: 7200 NKDIADDEVATWIQDCND-LLKGLGTVK----DSLFFLHELGEQLKQQ------VDASAA 7248
Query: 3666 KTLEQ-ALQLARRLHSTHEELCTWLDKVEVELLSYET----------------QVLKGEE 3708
++ L L++ L + + LC ++ +L YET ++L+G++
Sbjct: 7249 SAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQD 7308
Query: 3709 ASQA------QMRPKELKKEAKNNKAL---LDSLNEVSSALLELVPWRAREGLEKMVAED 3759
S + Q R +ELK + ++ LD LNE+ L P +E K +
Sbjct: 7309 PSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRL----PLNDKE--IKRMQNL 7362
Query: 3760 NERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTS 3819
N + L+S T++ ++ + +L+ Q F + + + ++ +TE+KL +I
Sbjct: 7363 NRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAV--EISGNYQHLL 7420
Query: 3820 AQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQIN 3879
Q + + F E+ + I+ ++ G +++ +++ KL + + + +
Sbjct: 7421 EQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRA 7480
Query: 3880 SERYLQLERAQSLVNQFWETYEELWPWLTETQSI----ISQLPAPALEYETLRQQQEEHR 3935
+R ++ ++ E E+L WL E + + +P P + TL + +
Sbjct: 7481 QQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKE 7540
Query: 3936 QLRELIAEHKPHIDKMNKTGPQLLELSPG-------EGFSIQEKYVAADTLYSQIKEDVK 3988
++ + + +I + LL G E IQEK+ +A +++E K
Sbjct: 7541 KV--FLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASM---RLEEQKK 7595
Query: 3989 KRAVALDEAISQSTQFHDKIDQILESLERIVERLRQP-PSISAEVEKIKEQISENKNVSV 4047
K A L + D ++++ +++ + L + AE + KE + + +
Sbjct: 7596 KLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTD 7655
Query: 4048 DMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKL 4107
D+ +L L +TL A D I + ++++ + WE + + R ++
Sbjct: 7656 DLTQLSLLKDTLS-------AYISADDISI----LNERVELLQRQWEELCHQLSLRRQQI 7704
Query: 4108 LDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQE 4167
+ + F + L + + + D I+ + K +++ +EEI QE
Sbjct: 7705 GERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLKKD----YQEEIAIAQE 7760
Query: 4168 ELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQ 4227
+ +G L A E ++ + ++N W L R+ KL+E + A Q
Sbjct: 7761 NKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLD 7820
Query: 4228 DGLQAVFDWVDIAGGKLASMSPIGTDL---ETVKQQIEELKQFKSEAYQQQIEMERLNHQ 4284
+ ++ W+ +LA PI D E +++++ E ++ + + + + + +
Sbjct: 7821 KNMSSLRTWLAHIESELAK--PIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNL 7878
Query: 4285 AELLLKKV---TEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALD 4341
E+LL +++ ++Q L W ++ + R+ K+E +F
Sbjct: 7879 CEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYS 7938
Query: 4342 ELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIES 4401
WL +E + G + EL K Q V + +E +NK L
Sbjct: 7939 RFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARE 7998
Query: 4402 SAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTER 4461
+ + A +L+ + NQRW N+ ++ ++L + Q + F + + WLT+ +
Sbjct: 7999 NRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDL 8058
Query: 4462 HLLASKPLGGLPETAK-EQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNID 4520
L + AK +QL + + K E ++ +G+Q++ + I+
Sbjct: 8059 QLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIE---QIIAQGEQLIEKSEPLDAAIIE 8115
Query: 4521 QDINNLKEKWESV-------------------ETKLNERKTKLEEALNLA-MEFHNSLQD 4560
++++ L+ + V E L++R+ +LE++ L+ + +H+ D
Sbjct: 8116 EELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSAD 8175
Query: 4561 FINWLTQAEQTLNVASRPSL-----------ILDTVLFQIDEHKVFANEVNSHREQIIEL 4609
+ Q L+++ L +D++ + D + ++ S + +
Sbjct: 8176 SL-LSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPS 8234
Query: 4610 -DKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDA-RKRAKQFHEAW 4667
D+ G K F + V L ++ + K+ + ++ A + +Q +A
Sbjct: 8235 EDEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKAL 8294
Query: 4668 SKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKE 4727
++++E + S+ + D +K + K LG S D+ R LKE
Sbjct: 8295 DDSRFQIQQTENIIRSKTPTGPELD------TSYKGYMKLLGECSSSIDSVKRLEHKLKE 8348
Query: 4728 KTSLADDNLKL---DDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWL 4784
+ + L + + + D+W+ + +++ ++ ++++ L QF L ++ WL
Sbjct: 8349 EEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWL 8408
Query: 4785 YRVEPQLAEDQPVH--GDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDD 4842
E +L + Q + DI + I K QK + R + + ++ + E + +
Sbjct: 8409 GDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKE 8468
Query: 4843 SSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFH 4902
S ++ ++ +++ RW+ VC+L + L+ AL Q + FH + H LL L ++ R +
Sbjct: 8469 SRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDR--RKN 8526
Query: 4903 GVLPDDEDA-LRTLIDQHKEFMK---KLEEKRAELNKATTMGDTVLAICHPDSITTIKHW 4958
++P D + L D HK+ M+ +L E + + M +L K
Sbjct: 8527 EIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEK 8586
Query: 4959 ITIIRARFEEVLAWAKQHQQRLASALAGLIAKQEL 4993
+ +I R + +L +H + L L ++Q+L
Sbjct: 8587 VHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQDL 8621
Score = 286 bits (731), Expect = 5e-76
Identities = 864/4710 (18%), Positives = 1776/4710 (37%), Gaps = 672/4710 (14%)
Query: 400 KEWGKLIIAMLEREKA--LRPEV-ERLEMLQQIANRVQRDSVICEDKLILAGNALQSDSK 456
+E G+ + LE +A LR E+ + +E L+++ + V+++ + E L LA K
Sbjct: 3753 REKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLA-KEFSDKCK 3811
Query: 457 RLESGVQ----------------FQNEAEIAGYILECENLLRQHVIDVQILIDGKYYQAD 500
L + ++ +A+++ Y L+Q V+ + + + +
Sbjct: 3812 ALTQWIAEYQEILHVPEEPKMELYEKKAQLSKY-----KSLQQTVLSHEPSVKSVREKGE 3866
Query: 501 QLVQRV--AKLRDEIMALRNECSSVYSKGRILTTE-------------QTKLMISGITQS 545
L++ V L+D+I L+++ + S G+ + E + +I
Sbjct: 3867 ALLELVQDVTLKDKIDQLQSDYQDLCSIGKAMMEEIAGFEDRLNNLQMKGDTLIGQCADH 3926
Query: 546 LNSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPSGLVP 605
L + Q +H L T+ M L + ++ T + S + P
Sbjct: 3927 LQAKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQP 3986
Query: 606 NFSSGVEPNSLQTLKLMQIR-----------------------KPLLKSSLLDQNLTEEE 642
+ +P + + Q++ +K++ D TE+
Sbjct: 3987 DLEPSPQPPLSRAEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQT 4046
Query: 643 INMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISE 702
I K VQ +++ ++E L + L+N K H E E ++ + +S+
Sbjct: 4047 IEQKLVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNMKRRH---SELELNIAQNMVSQ 4103
Query: 703 IQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEE 762
++ + + +L+S+ A + N + N+L +KEE
Sbjct: 4104 VK----------DFVKKLQSKQASV---------------NTIIEKVNKL---TKKEE-- 4133
Query: 763 VAYDWSERNTNIARKKDYHAELMRELD----QKEENIKSVQEIAEQLLLENHPARLTIEA 818
S + I D +L R+ + Q+EE+++ ++ H +E
Sbjct: 4134 -----SPEHKEINHLNDQWLDLCRQSNNLCLQREEDLQRTRDY--------HDCMNVVEV 4180
Query: 819 YRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKD---AIQRKYSCD 875
+ T+W + + +DA+ +L LK A+Q +
Sbjct: 4181 FLEKFTTEWDNLAR-------------------SDAESTAVHLEALKKLALALQ-----E 4216
Query: 876 RSSSIHKLEDLVQESME-----EKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSI 930
R +I L+D Q+ +E +KE + + S + + + +I+ K
Sbjct: 4217 RKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKI----------- 4265
Query: 931 PIKAICDYRQIEITIYKDDECVLANNSHRAKW-KVISPTGNEAMVPSVCFTVPPPNKEAV 989
Q+ +T ++ V + +W + P EA+ S PPP
Sbjct: 4266 ---------QVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQS-----PPP----- 4306
Query: 990 DLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPG------ 1043
D+A + + + + + +KS LI + DR+ A + + ++
Sbjct: 4307 DMAQNLLMDHLAICSELEAKQMLLKS------LIKDADRVMADLGLNERQVIQKALSDAQ 4360
Query: 1044 EHQQVLSNLQSRFEDFLED--SQESQ----VFSGSDITQ------------------LEK 1079
H LS+L + +L S+++Q VF + Q + K
Sbjct: 4361 SHVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSK 4420
Query: 1080 EVNVCK------QYYQ-----------ELLKSAEREEQEE------SVYNLYISEVRNIR 1116
+V CK + YQ EL+K +E+ E + ++Y S ++
Sbjct: 4421 QVKTCKSAQASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCS 4480
Query: 1117 LRLENCEDRLIRQIRTPLERDD----LHESVFRITEQEKLKKELERLKDDLGTITNKCEE 1172
RL+ E L+ + + D L ++ + L E L L N E+
Sbjct: 4481 HRLQELEKNLVSRKHFKEDFDKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQ 4540
Query: 1173 --------FFSQAAASSSVPTLRS--------ELNVVLQNMNQVYSMSSTYIDKLKTVNL 1216
Q + +P+L +LN + + N + +++ DK V
Sbjct: 4541 SPEYENLLLTLQRTGQTILPSLNEVDHSYLSEKLNALPRQFNVIVALAK---DKFYKVQE 4597
Query: 1217 VLKNTQAAEALVKLYETKLCEEEAVIADKNNI------ENLISTLKQWRSEVDEKRQVFH 1270
+ + +L++L L E EA + + E +S R+ +DE +
Sbjct: 4598 AILARKEYASLIELTTQSLSELEAQFLRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGE 4657
Query: 1271 ALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGK 1330
A+++ QK + R W +K LV + + Q + R+ LE
Sbjct: 4658 AVDELNQKKEGF----------RSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTS 4707
Query: 1331 SLKYYRDTYHPLDDWIQQVETTQRKI-QENQPENSK-----TLATQLNQQKMLVSEIEMK 1384
+ + + L+ ++ V+ Q K+ +E P K +LA L +++ + +
Sbjct: 4708 AYQEHEKMCQQLERQLKSVKEEQSKVNEETLPAEEKLKMYHSLAGSLQDSGIVLKRVTIH 4767
Query: 1385 QSKMDE------CQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQ 1438
+ +K Q + + +L T V + V+ Q+ +
Sbjct: 4768 LEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSRSLD 4827
Query: 1439 EFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISK 1498
++ + V L +L+ ++EE + ++ ++E V+ + + +S+
Sbjct: 4828 WLRRVKAELSGPVYLDL--------NLQDIQEEIRKIQIHQEE-VQSSLRIMNALSH--- 4875
Query: 1499 TLKDAEKAGKPPFSKQKISSE------EISTKKEQLSEALQTIQLFLAKHGDKMTDEERN 1552
K+ EK K +K+ IS++ E+S + EAL+T Q L E +
Sbjct: 4876 --KEKEKFTK---AKELISADLEHSLAELSELDGDIQEALRTRQATLT--------EIYS 4922
Query: 1553 ELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQ 1612
+ ++ + Q + + L ++ + LQ + DV+ E+ + + + + Q +L +
Sbjct: 4923 QCQRYYQVFQAANDWL-EDAQELLQLAGNGLDVESAEENLKSHMEFFSTEDQFHSNL--E 4979
Query: 1613 TENRLIGHQEAFMIGDGTVELKK----YQSKQEELQKDMQGSAQALAEVVKNTENFLKEN 1668
+ L+ + + G +L++ + + + + +D L ++ K
Sbjct: 4980 ELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQKAR 5039
Query: 1669 GEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEE 1728
E + + E+KL+E + + +AE+ E K + + + EK+ A LEE
Sbjct: 5040 EEVIELMNDT--EKKLSEFSLLKTSSSHEAEEKLSE-HKALVSVVNSFHEKIVA---LEE 5093
Query: 1729 SKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETD 1788
+++E D+ +A T +Q A+ ++ E +LE
Sbjct: 5094 KASQLEK-------TGNDASKATLSRSMT-----TVWQRWTRLRAVAQDQE---KILEDA 5138
Query: 1789 VD------GQVGTTQENLNQQYQKV---------KAQHEKIISQHQAVIIAT---QSAQV 1830
VD +V E ++Q K+ KA+ ++ H ++ QSA
Sbjct: 5139 VDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALG 5198
Query: 1831 LLEKQ-------GQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEEL---E 1880
+L +Q G +P E+ L M+E+ + L EK +++EL E
Sbjct: 5199 MLRQQTLSMLQDGAAPTPGEEPPL---MQEITAMQDRCLNMQEKVKTNGKLVKQELKDRE 5255
Query: 1881 KFDADYTEFEHWLQQSEQELEN----LEAGADDINGLMTKLKRQKSFSEDVISHKGD--L 1934
+ + W+Q++++ L N ++A +++ L+T+ + E + + + L
Sbjct: 5256 MVETQINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAEEQKEKYL 5315
Query: 1935 RYITISGN----RVLEAAKSCSKRDG-----GKVDTS-ATHREVQRKLDHATDRFRSLYS 1984
TI + ++ E A RD +V+ S AT +E+ R++ ++ +
Sbjct: 5316 GLYTILPSELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILT 5375
Query: 1985 KCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETK 2044
K +N+ + + G + L +A K L + + ++ + T+
Sbjct: 5376 KLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTE 5435
Query: 2045 ALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKS-VNERN 2103
Q I + + KL + A L + L I+K G S S + E+
Sbjct: 5436 LHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQY 5495
Query: 2104 EKLQITLTRSLSVQDGLDEM---LDWMGNVESSLKEQGQVP---LNSTALQDIISKNIML 2157
Q L S + L+ M L ++ +V + K QV + L+ +I +
Sbjct: 5496 ILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQN 5555
Query: 2158 EQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEE 2217
QD A A +K++ +E +T +S + L + S H L++ME
Sbjct: 5556 LQDAAKDMKKFEAELKKLQAALEQAQ-ATLTSPEVGRLSLKEQLSHRQH----LLSEMES 5610
Query: 2218 LKTKVELFE------NLSEKLQTFLETKTQALT-EVDVPGKDVTELSQ--YMQESTSEFL 2268
LK KV+ + + E + L AL + + T + Q MQ + ++
Sbjct: 5611 LKPKVQAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYE 5670
Query: 2269 EHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQL 2328
++++ ++ L L++ +H DK + L + E E + + QEQ+
Sbjct: 5671 QYEQEMKHLQQLIE--GAHREIEDKPVATSNIQELQAQISRHE----ELAQKIKGYQEQI 5724
Query: 2329 DAFQVLVKSLKSWIKETTKKVPIVQP---SFGAEDLGKSLEDTKKLQEKWSLKTP----- 2380
+ K L K T + + + + G EDL L T + T
Sbjct: 5725 ASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHT 5784
Query: 2381 --------EIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGA---VLNGEGTATN----- 2424
++ NS IS + + A A+V A L+ E T+
Sbjct: 5785 LLSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIH 5844
Query: 2425 -----TEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAM 2479
++EF+ S + D+ +E L ++ +K L L + QK Q+ ++
Sbjct: 5845 PSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSI 5904
Query: 2480 MQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTE-LLE 2538
KM K ++P P + ++Q+ ++++ E+ +++ EL+ L E L+
Sbjct: 5905 ST---KMEAIELKLSESPEPG--RSPESQMAEHQALMDEILMLQDEINELQSSLAEELVS 5959
Query: 2539 EN--PDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQ--- 2593
E+ D E + LT + + + ++Q LEE N+ + Q E L++
Sbjct: 5960 ESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRC 6019
Query: 2594 -------WLVE-KELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQG 2645
WL+ K + + L P +P + Q Q +L E + +L+ +
Sbjct: 6020 EADELDSWLLSTKATLDTALSPPK-EPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNEN 6078
Query: 2646 ILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDK 2705
+L + K++ + K L G L + Q + Q + +
Sbjct: 6079 LLLEG------KAHTKDEAEQLAGKLRRLKGSLLEL-----QRALHDKQLNMQGTAQEKE 6127
Query: 2706 LSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEY 2765
SD+D + S V + + Q T + +Q Q++K+++ Q L E S L
Sbjct: 6128 ESDVDLTATQSPGVQ---EWLAQARTTWTQQRQSSLQQQKELE--QELAEQKSLLRSVAS 6182
Query: 2766 LKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNK 2825
E+ Q ++ D +K + Q L S QM W +E
Sbjct: 6183 RGEEILIQ-HSAAETSGDAGEKPDVLSQELGMEGEKSSAEDQMR---MKWESLHQE---- 6234
Query: 2826 SHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNT 2885
S K +L+++++ + E+ + N LL K + Q +
Sbjct: 6235 ---FSTKQKLLQNVLEQEQ-------------EQVLYSRPNRLLSGVPLYKGDVPTQDKS 6278
Query: 2886 IKTNW-DTFNKQVKERENKL----KESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLD 2940
T+ D N+ +E ++ ++S+ K + V W+D + L + L
Sbjct: 6279 AVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLF-VATALL 6337
Query: 2941 PAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMV 3000
P E E + + L K++ + ++ N + +++V+ D L+ ++ ++
Sbjct: 6338 PEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLL 6397
Query: 3001 TEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQT 3060
++ + ++ Q+ FQ K L + NKY+ + +
Sbjct: 6398 DSVVNQRCHQMKERLQQILNFQNDLKV-----------------LFTSLADNKYIILQKL 6440
Query: 3061 QQKSLQALKHQVDLAKRLAQDLVVEAS----DSKGTSDVLLQVETIAQEHSTLSQQVDEK 3116
Q + Q++ ++ A+D + E + K D L + QE S L DE
Sbjct: 6441 ANVFEQPVAEQIEAIQQ-AEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSKLQDMYDEL 6499
Query: 3117 CSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGR-----DAETLQKQKETIKAF 3171
+ ++ G+ N + SQ+ +L + G+ D + + KE I+
Sbjct: 6500 MMIIGSRRSGL----NQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQL 6555
Query: 3172 LKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEA-----LSKQCNKLLDRAQAR 3226
L K + ++ M+ TE ++ E L Q + +L RA R
Sbjct: 6556 LDKHKEYFQGLESH------MILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKR 6609
Query: 3227 EEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGP-VGMETETINQQLNMFKVFQ--K 3283
++E + E +S L E L + E ES P VG+ E ++ ++ ++Q K
Sbjct: 6610 GVELEYIL----ETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLK 6665
Query: 3284 EEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQE 3343
+ Q K V G+ L+ S S LE L+ + W + K+++ +L+
Sbjct: 6666 SSLNEYQPKLYQVLDDGKRLLISI----SCSDLESQLNQLGECWLSNTNKMSKELHRLET 6721
Query: 3344 ALLHCGRFQDALESLLSWMVDTEELVANQKPPSA----EFKVVKAQIQEQKLLQRLLDDR 3399
L H R+Q L+ W+ ++ + S E ++V+ + + +D +
Sbjct: 6722 ILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQ 6781
Query: 3400 KSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQ 3459
S + G ++ + D + +LS +DS+W LL +L + +
Sbjct: 6782 SSLKSSVLSTGNQLLRLKK-VDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLP 6840
Query: 3460 FHETLEPLNEWLTTIEKRLVNCEP-----IGTQASKLEEQIAQHKALEDDIINHNKHLHQ 3514
+ + W++ +E + E IG +A + E + ++K + DI N
Sbjct: 6841 SRHAISEVMSWISLMENVIQKDEDNIKNSIGYKA--IHEYLQKYKGFKIDI---NCKQLT 6895
Query: 3515 AVSIGQSLKVLSSREDKDMVQSKLDFSQV-------WYIEIQEKSHSRSELLQQALCNAK 3567
+ QS+ +SS++ + K DF++ W I +Q + +LL+ L +
Sbjct: 6896 VDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQI-LQGLVTEKIQLLEGLLESWS 6954
Query: 3568 IFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLN 3627
+ E+ V+ + E +K K + + + + L++ I +++ V++ N
Sbjct: 6955 EY-ENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQN 7013
Query: 3628 GLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCT 3687
GL L++ D I+ L + + ++ + + L+ L +++ +
Sbjct: 7014 GLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINS 7073
Query: 3688 WLDKVEVELLSYETQVLKGE-EASQAQM-RPKELKKEAKNNKALLDSLNEVSSALLELVP 3745
+L + L + ++L G EA Q Q+ + L+ + + + L +++ LL+
Sbjct: 7074 YLMEARYSLSRF--RLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECH 7131
Query: 3746 WRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKL 3805
E L + E N R+ + + I ++++ A + Q++ + S + + E +
Sbjct: 7132 PPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRT 7191
Query: 3806 MSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKL 3865
L +D ++ ++L+ + D + H++ ++ S +
Sbjct: 7192 NELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAI 7251
Query: 3866 DK-VLKNYDTICQINSERYLQLERAQSLV---NQFWETYEELWPWLTETQSIIS-QLPAP 3920
L +C + Q Q+ V F ++ E L W+ E + I+ Q P+
Sbjct: 7252 QSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSH 7311
Query: 3921 ALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLY 3980
+ + T++++ EE + + P +D++N+ G +L L+ E +Q + +
Sbjct: 7312 SSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRL-PLNDKEIKRMQN----LNRHW 7366
Query: 3981 SQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQIS 4040
S I +R L + Q F +K + +E L + ++L IS + + EQ
Sbjct: 7367 SLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAV--EISGNYQHLLEQQR 7424
Query: 4041 ENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLV 4100
++ +M Q + ++ G+ ++ + D+D KL + W+ +
Sbjct: 7425 AHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRD----EFNLKLTLLSNQWQGVIRRA 7480
Query: 4101 EEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIRE 4160
++R +++ + W + + ++ + L G+ + QQ A T+ +
Sbjct: 7481 QQRRG----IIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQ--ARTLFD 7534
Query: 4161 EID-------GLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRI 4213
E+ Q + + G +L+ + + ++ + E+ W S + +++
Sbjct: 7535 EVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQK 7594
Query: 4214 DKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQ 4273
KL ++ DW G S+ + T + + Q + + + E +
Sbjct: 7595 KKLAFLLK-------------DWEKCEKGIADSLEKLRTFKKKLSQSLPDHHE---ELHA 7638
Query: 4274 QQIEMERLNH----------QAELL---LKKVTEESDKHTVQDPLMELKLIWDSLEERII 4320
+Q+ + L + Q LL L D + + + L+ W+ L ++
Sbjct: 7639 EQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLS 7698
Query: 4321 NRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIE-IELAKHHVLQN 4379
R+ ++ L F EL WLT E +S+ GD E IE K +
Sbjct: 7699 LRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQN----GDILIEEMIEKLKKDYQEE 7754
Query: 4380 DVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGAL 4439
+A ++ ++ + + G L ++S +AS ++ KL +N RWQ++L+ R ++L L
Sbjct: 7755 IAIAQENKIQ-LQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETL 7813
Query: 4440 RQAKGFHGEIEDLQQWLTDTERHLLASKPL---GGLPETAKEQLNVHMEVCAAFEAKEET 4496
+ + L+ WL E L +KP+ E + +LN E+ E
Sbjct: 7814 VAVQQLDKNMSSLRTWLAHIESEL--AKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTG 7871
Query: 4497 YKSLMQKGQQMLARCPKSAET----NIDQDINNLKEKWESVETKLNERKTKLEEALNLAM 4552
S++ + +L C A +I Q NL +W ++ ER+ K+EE L
Sbjct: 7872 VASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQ 7931
Query: 4553 EFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKT 4612
+F + F +WL +E+T S +I ++ + + F +V+ Q+ ++K
Sbjct: 7932 KFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQ 7991
Query: 4613 GTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLME 4672
L ++ +K ++ RW+ + +R+ R L + ++F A ++
Sbjct: 7992 YRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILV 8051
Query: 4673 WLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLA 4732
WL E + L + +E ++ D ++ ++ Q K FQ+ + H+ + G L EK+
Sbjct: 8052 WLTEMDLQL-TNIEHFSECD-VQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPL 8109
Query: 4733 DDNLKLDDMLSELRDKWDTICGKSVERQNK 4762
D + +++ L ELR + G+ VER +K
Sbjct: 8110 DAAI-IEEELDELRRYCQEVFGR-VERYHK 8137
Score = 281 bits (719), Expect = 1e-74
Identities = 768/4289 (17%), Positives = 1651/4289 (38%), Gaps = 539/4289 (12%)
Query: 1045 HQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESV 1104
HQQ + ++ D + ++Q G + +E+ + L +S ER+E+ V
Sbjct: 1285 HQQKTKRISAKKRDVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERSRERQERRIQV 1344
Query: 1105 YNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKD--- 1161
+R R E ++ ++R + + HE + E L ELE+ K+
Sbjct: 1345 ------TLRKWE-RFETNKETVVRYL---FQTGSSHERFLSFSSLESLSSELEQTKEFSK 1394
Query: 1162 DLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMN-QVYSMSSTYIDKLKTVNLVLKN 1220
+I + E +A+ P + L +++ QV + T + +KT+ +V
Sbjct: 1395 RTESIAVQAENLVKEASEIPLGPQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTK 1454
Query: 1221 TQAAEALVKLYETKLCEEE----AVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDEL 1276
+ + + E+E A+ + ++ IS +K E++ K LE+E
Sbjct: 1455 WDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIKVTIQEIESKLSSIVGLEEEA 1514
Query: 1277 QKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYR 1336
Q S F T E +I +L + G+ L+ +
Sbjct: 1515 Q-----SFAQFVTTGES----------------------ARIKAKLTQIRRYGEELREHA 1547
Query: 1337 DTYHPLDDWI-------QQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMD 1389
L+ I Q+ E RKIQ++ E LA + ++ Q MD
Sbjct: 1548 QC---LEGTILGHLSQQQKFEENLRKIQQSVSEFEDKLAVPIKICSSATETYKVLQEHMD 1604
Query: 1390 ECQKYAEQYSATV-------KDYELQTMTYRAMVDSQQKSPVKRR--RMQSSADLIIQEF 1440
CQ SA K + A QQ + RR Q++ + ++ +
Sbjct: 1605 LCQALESLSSAITAFSASARKVVNRDSCVQEAAALQQQYEDILRRAKERQTALENLLAHW 1664
Query: 1441 MDLRTRYTALVTLM--------TQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKA----KE 1488
L ++ +T + + + + D +K +E E + ++ + E V +A K
Sbjct: 1665 QRLEKELSSFLTWLERGEAKASSPEMDISADRVK-VEGELQLIQALQNEVVSQASFYSKL 1723
Query: 1489 LQKWVSNISKTLKDAEKAGK-------------PPFSKQKIS-SEEISTKKEQLSEALQT 1534
LQ S S KD K K P ++I+ + + + +Q E L +
Sbjct: 1724 LQLKESLFSVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLS 1783
Query: 1535 ----IQLFLA------------------KHGDKMTDEE--RNELEKQVKTLQESYNLLFS 1570
I+LFL+ +H D + E + EL+ L + +L +
Sbjct: 1784 FSVWIKLFLSELQTTSEISIMDHQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRA 1843
Query: 1571 ESLKQLQ-ESQTSGDVKVEEKIVAERQQ----------EYKEKLQGICDLLTQT------ 1613
E L LQ +++ + E V ER+Q + L GI L QT
Sbjct: 1844 EDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNS 1903
Query: 1614 ----ENRLI------------GHQEAFMIGDGTVELKKYQSK--QEELQKDMQGSAQALA 1655
E+ LI + A + DG + +Y K E + + +A L
Sbjct: 1904 MNKNESDLIEKDLNDALQNAKALESAAVSLDGILSKAQYHLKIGSSEQRTSCRATADQLC 1963
Query: 1656 EVVKNTENFLKENGEKLSQEDK-ALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIK 1714
V+ +N L G K S+ D A++++ + K E+L E ++ DK +K
Sbjct: 1964 GEVERIQNLL---GTKQSEADALAVLKKAFQDQK---EELLKSIEDIEERTDK---ERLK 2014
Query: 1715 EET-----EKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGD 1769
E T +++ QLE+ E+ L WL + K KQ+ +++
Sbjct: 2015 EPTRQALQQRLRVFNQLEDELNSHEHELCWLKD----------KAKQIAQKD-------- 2056
Query: 1770 GKSAIGEEDEVNGNLLETDVDGQVGTTQEN---------LNQQYQKVKAQHEKIISQHQA 1820
A E + N LE D EN L ++YQ +K+ K++ +
Sbjct: 2057 --VAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVSKVLENASS 2114
Query: 1821 VIIATQSAQVLLEKQGQYLSPE-EKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEEL 1879
VI+ + + + + + E K K+ K+L ++ + ++K HS L
Sbjct: 2115 VIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLD-NFTSKGKHLLSELKKIHSSDFSL 2173
Query: 1880 EKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITI 1939
K D + T + WL SE+ EN M +L+ S +DV+S + ++
Sbjct: 2174 VKTDMEST-VDKWLDVSEKLEEN-----------MDRLRVSLSIWDDVLSTRDEIE--GW 2219
Query: 1940 SGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLK----- 1994
S N V + A++ S D + +E + ++ + R L+SK N L K
Sbjct: 2220 SNNCVPQMAENISNLD-NHLRAEELLKEFESEVKNKALRLEELHSKVNDLKELTKNLETP 2278
Query: 1995 --------DLVDKYQHYE---DASCGLLAGLQACEATASKHLSEPIAVDPK--------- 2034
DL+ K +H + + + G L A K +++ K
Sbjct: 2279 PDLQFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCA 2338
Query: 2035 --NLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRY 2092
L++ K +Q ++ SQQ + ++ L R + + + ++ ++
Sbjct: 2339 QNETCEALKKVKDIQKELQSQQSNISSTQENLNSL--CRKYHSAELESLGRAMTGLIKKH 2396
Query: 2093 EDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIIS 2152
E +S+ ++ LQ +L + S + + E +W +++ KE +S L+ +
Sbjct: 2397 EAVSQLCSKTQASLQESLEKHFS--ESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLH 2454
Query: 2153 KNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETL 2212
+ ++ QS ++A+ ++ + SS+Q ++ + F + +
Sbjct: 2455 DLQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDK 2514
Query: 2213 AKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKK 2272
+++ +++ FE+ KL ++ + +++ E Q++ E +E HK
Sbjct: 2515 QALQDCASELGSFEDQHRKLNLWIHEMEERFNT-----ENLGESKQHIPEKKNEV--HKV 2567
Query: 2273 HLEVLHSLLKEISSHGLPSDKALVLEKTNN--------LSKKFKEMEDTIKEKKEAVTSC 2324
+ L LL S S + +L + + S+ ++ ++ KE + SC
Sbjct: 2568 EM-FLGELLAARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSC 2626
Query: 2325 QEQLDAFQVLVKSLKS---WIKETTKKVPIVQPSFGAED-LGKSLEDTKKLQEKWSLKTP 2380
Q L + L ++L+S W+K ++ + + G++D L K L ++Q+ +K
Sbjct: 2627 QVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRL---SQIQDILLMKGE 2683
Query: 2381 EIQKVNNSGISLCNLISAVTTPAKAI-AAVKSGGAVLNGEGTATNTEEFWANKGLTSIKK 2439
K+N A+ +A+ ++ K G V+ + +E WA+ +S+
Sbjct: 2684 GEVKLN----------MAIGKGEQALRSSNKEGQRVIQTQ--LETLKEVWADIMSSSVHA 2731
Query: 2440 DMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAP 2499
T L + +S+ E + + QW++ +++ Q P P
Sbjct: 2732 QST-------------------LESVISQWNDYVERKNQLEQWMESVDQKIEHPLQ-PQP 2771
Query: 2500 TDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSK 2559
E ++ +S +E + + + L K EL E+ D ++ E+ ++
Sbjct: 2772 GLKEKF-VLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQE---ELKTQ 2827
Query: 2560 WQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQR 2619
+ ++ + ++ +K+EE + + + WL + + +S D + +
Sbjct: 2828 FNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDSSATQKKL 2887
Query: 2620 QQVQIL----------LQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQ 2669
+++ L L + P+ +Q T A G E +LR K+ +V Q
Sbjct: 2888 SKIKELIDSREIGASRLSRVESLAPEVKQNTTA-SGCELMHTEMQALRADWKQWEDSVFQ 2946
Query: 2670 KWDSLTG----------QLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAV 2719
L + S + ++QA+ Q+ +LL++ + +L+ L+ K + V
Sbjct: 2947 TQSCLENLVSQMALSEQEFSGQVAQLEQAL---EQFSALLKTWAQQLTLLEGKNTDEEIV 3003
Query: 2720 STHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILK 2779
+ L+ QK + + K Q+ DLS S ++ G++K
Sbjct: 3004 ECWHKG-QEILDALQKAEPRTEDLKSQLNELCRFSRDLST----------YSGKVSGLIK 3052
Query: 2780 SFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESL 2839
+ + +A Q+ + +F++ RDFQ WL K K I + + +
Sbjct: 3053 EYNCLCLQASKGCQNKEQIL--QQRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVSTS 3110
Query: 2840 IKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKE 2899
++ ++F H +++GE L + +Q ++ K +W F+ + +
Sbjct: 3111 LQKIQEFLSESENGQHKLNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQ 3170
Query: 2900 RENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCL-DPAEGENSIAKLKSLQKEM 2958
+E+ L+ + ++ E + W+ K + + E L D KL+S+ +E+
Sbjct: 3171 KESALENLKIQMKDFEVSAEPIQDWLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEI 3230
Query: 2959 DQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMT-QK 3017
+ + L A L E ++ + QL S+ L N+T +K
Sbjct: 3231 HCYEPQLNRLKEKAQQLW------------EGQAASKSFRHRVSQLSSQYLALSNLTKEK 3278
Query: 3018 FKEFQEVSKESKRQLQCAKEQLD-----IHDSLGSQAYSNKYLTMLQTQQKSLQALKHQV 3072
+ E + KE D IH L S + ++L ++ L+AL V
Sbjct: 3279 VSRLDRIVAEHNQFSLGIKELQDWMTDAIH-MLDSYCHPTSDKSVLDSRTLKLEALL-SV 3336
Query: 3073 DLAKRLAQDLVVEASDS-------KGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQ 3125
K + ++V +S +G + Q++++ ++L S LE L
Sbjct: 3337 KQEKEIQMKMIVTRGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEGALS 3396
Query: 3126 GIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNA 3185
+Q+ +R QF+ + D +++ + K T+ K L + S +
Sbjct: 3397 KWTSYQDGVR----QFSGWMDSMEANLNESERQHAELRDKTTMLGKAKLLNEEVLSYSSL 3452
Query: 3186 NKTCKMMLA--TEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSK 3243
+T ++ A TE L +L+ L ++ + +RA+ + E ++ +E+
Sbjct: 3453 LETIEVKGAGMTEHYVTQL-----ELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRD 3507
Query: 3244 LKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGL 3303
LK F + L + +E + + + T L + Q E GQ L
Sbjct: 3508 LKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAE------------GQAL 3555
Query: 3304 IQS-------AAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALE 3356
+ S S Q + L+ + W+ ++++ Q + + +
Sbjct: 3556 LNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQ 3615
Query: 3357 SLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATT 3416
+ W+ EE +++ + +V + + Q++L + + + + A
Sbjct: 3616 QVDEWLKTAEEKKWHEEVTAYRDEVEEVGARAQEILDESHVNSRMGCQATQLTSRYQALL 3675
Query: 3417 AEPADKVKIL-KQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFH-----------ETL 3464
+ +++K L +++ L+ +L + ++ + VA + +TL
Sbjct: 3676 LQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKTL 3735
Query: 3465 EPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHL----------HQ 3514
E L + + L + G +A K E+ + + L +I +H + L H
Sbjct: 3736 EVLLKDMEKGHSLLKSAREKGERAVKYLEE-GEAERLRKEIHDHMEQLKELTSTVRKEHM 3794
Query: 3515 AVSIGQSLKVLSSREDKDMVQSKLDFSQVWYI------EIQEKSH--SRSELLQQALC-- 3564
+ G L S + K + Q ++ ++ ++ E+ EK S+ + LQQ +
Sbjct: 3795 TLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSH 3854
Query: 3565 --NAKIFGEDEVELMNWLNEV--HDKLSKL--SVQDYSTEGLWKQQSELRVLQEDILLRK 3618
+ K E L+ + +V DK+ +L QD + G + + E+I +
Sbjct: 3855 EPSVKSVREKGEALLELVQDVTLKDKIDQLQSDYQDLCSIG--------KAMMEEIAGFE 3906
Query: 3619 QNVDQALLNGLELLKQTTGDEVLIIQDK----LEAIKARYKDITKLSTDVAKTLEQALQL 3674
++ + G L+ Q ++ L+ K Y I + + ++LE LQ
Sbjct: 3907 DRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQK 3966
Query: 3675 ARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLN 3734
T ++ WL V+ +L L EA + + L+++A+ LL S+
Sbjct: 3967 HVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRALQEQARTYLDLLCSMC 4026
Query: 3735 EVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAE 3794
++S+A ++ ++ + E+ + + +TQ EEI + Q AD +
Sbjct: 4027 DLSNASVKTTAKDIQQ-----TEQTIEQKLVQAQNLTQGWEEIKHLKSELWIYLQDADQQ 4081
Query: 3795 LSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACS 3854
L + K+ S ++ + Q+ S QV K F ++ + ++ +++ +K+ +
Sbjct: 4082 L----QNMKRRHSELELNIAQNMVS---QV-KDFVKKLQSKQASVNTIIEKVNKL----T 4129
Query: 3855 EEEKQSMKKKLDKVLKNYDTICQINSERYLQLER----------AQSLVNQFWETYEELW 3904
++E+ K+++ + + +C+ ++ LQ E ++V F E + W
Sbjct: 4130 KKEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFLEKFTTEW 4189
Query: 3905 PWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPG 3964
L + + + + AL+ L Q+ ++ + +L + + I+ +N +L++
Sbjct: 4190 DNLARSDAESTAVHLEALKKLALALQERKY-AIEDLKDQKQKMIEHLNLDDKELVKEQTS 4248
Query: 3965 EGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQ 4024
+++++ + L IK ++ L+E ++F + ++ E I E L+Q
Sbjct: 4249 H---LEQRWFQLEDL---IKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQ 4302
Query: 4025 PPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQD 4084
P + + + ++ + ++E Q L ++L + + ++A G ++ + KA+ D
Sbjct: 4303 SP----PPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSD 4358
Query: 4085 KLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGID 4144
+ + LV +R L + +F I+ + I E +
Sbjct: 4359 AQSHV----NCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLL 4414
Query: 4145 PSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDS 4204
P V +Q + ++ + + Q E+ + G EL+ E +K V + EL S +DS
Sbjct: 4415 PDDVSKQVKTCKSAQASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDS 4474
Query: 4205 LNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWV---DIAGGKLASMSPIGTDLETVKQQI 4261
+ + R+ +LE+ + + +++ W+ DI ++ ++L T Q+
Sbjct: 4475 VLQKCSHRLQELEKNLVSRKHFKEDFDKACHWLKQADIVTFPEINLMNESSELHT---QL 4531
Query: 4262 EELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIIN 4321
+ + ++ + + + L + +L + E D + + L L ++ + +
Sbjct: 4532 AKYQNILEQSPEYENLLLTLQRTGQTILPSL-NEVDHSYLSEKLNALPRQFNVIVALAKD 4590
Query: 4322 RQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDV 4381
+ +K++ A+LA ++ ++ L+ E V D A+E L+ LQ+
Sbjct: 4591 KFYKVQEAILARKEYASLIELTTQSLSELEAQFLRMSKVPTD-LAVEEALS----LQDGC 4645
Query: 4382 LAHQSTVEAVNKAGNDLIESSAGEEASN---LQNKLEVLNQRWQNVLEKTEQRKQQLDGA 4438
A V + +A ++L + G ++ +K+ L + + +TEQR L+
Sbjct: 4646 RAILDEVAGLGEAVDELNQKKEGFRSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDT 4705
Query: 4439 LRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYK 4498
+ + L++ L + + A+E+L ++ + + + K
Sbjct: 4706 TSAYQEHEKMCQQLERQLKSVKEE---QSKVNEETLPAEEKLKMYHSLAGSLQDSGIVLK 4762
Query: 4499 SLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSL 4558
+ + + A I + + + + + + + E T+ E + +++F +
Sbjct: 4763 RVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQTEM 4822
Query: 4559 QDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKY 4618
++WL + + L+ L L + +I + ++ EV S + L + +
Sbjct: 4823 SRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNAL--SHKEKEK 4880
Query: 4619 FSQKQDVVL--IKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEE 4676
F++ ++++ +++ L + + + L R +L + + +++++ + +WLE+
Sbjct: 4881 FTKAKELISADLEHSLAELSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLED 4940
Query: 4677 SEKSLD---SELEIANDPDKIKTQL---AQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTS 4730
+++ L + L++ + + +K+ + + +F +L HS+ T + L + T
Sbjct: 4941 AQELLQLAGNGLDVESAEENLKSHMEFFSTEDQFHSNLEELHSLVATLD----PLIKPTG 4996
Query: 4731 LADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQ 4790
D L+ ++ L + + S + + L+ + A + +I+ + E +
Sbjct: 4997 KED----LEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKK 5052
Query: 4791 LAEDQPVH-GDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDS-SWVKV 4848
L+E + + HKA + + AL+ A +L + D S + +
Sbjct: 5053 LSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLEKTGNDASKATLSR 5112
Query: 4849 QMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDD 4908
M + RW + A++ ++ LE A+ + F++ V E + + + L
Sbjct: 5113 SMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKAS 5172
Query: 4909 EDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVL---AICHPDSITTIKHWITIIRAR 4965
+ L TL++ H F+ +LE++++ L ++L A P + IT ++ R
Sbjct: 5173 KAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDR 5232
Query: 4966 FEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKA 5025
+ K + + + L + + ++ W+Q + KE + E+ A
Sbjct: 5233 CLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQ--------ETKEYLGNPTIEIDA 5284
Query: 5026 LIAEHQTFMEEMTRKQPDVDKVTKTYKRR 5054
+ E Q + E T + +++K+ + K +
Sbjct: 5285 QLEELQILLTEATNHRQNIEKMAEEQKEK 5313
Score = 281 bits (718), Expect = 2e-74
Identities = 693/4177 (16%), Positives = 1601/4177 (38%), Gaps = 553/4177 (13%)
Query: 1152 LKKELERLKDDLGTITNKCEEFFS--QAAASSSVPTLRSELNVVLQNMNQVYSMSSTYID 1209
++++LE+ KD L F + + + +P +L + + + V S S ++
Sbjct: 449 IQRKLEQHKDLLQNTDAHKRAFHEIYRTRSVNGIPVPPDQLEDMAERFHFVSSTSELHLM 508
Query: 1210 KLKTVNL---VLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSE----- 1261
K++ + L +L AE+ +K + K E+V N + I K +
Sbjct: 509 KMEFLELKYRLLSLLVLAESKLKSWIIKYGRRESVEQLLQNYVSFIENSKFFEQYEVTYQ 568
Query: 1262 -VDEKRQVFHALEDELQKAKAISDEMFKTYKE-RDLDFDWHKEKA--DQLVERWQ---NV 1314
+ + +++ + +++A+ + M +T + R+L + ++ ++++ W N
Sbjct: 569 ILKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNT 628
Query: 1315 HVQIDNRLRDLEG-IGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQ 1373
+ L D E + +S +D + L WIQQ + ++ L Q
Sbjct: 629 VASLQAWLEDAEKMLNQSENAKKDFFRNLPHWIQQHTAMNDAGNFLIETCDEMVSRDLKQ 688
Query: 1374 QKMLVSE------IEMKQ-SKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKR 1426
Q +L++ +E+KQ ++ DE + ++Y+ D + + + P++
Sbjct: 689 QLLLLNGRWRELFMEVKQYAQADEMDRMKKEYT----DCVVTLSAFATEAHKKLSEPLEV 744
Query: 1427 RRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKA 1486
M + L+IQ+ D+ R V +M K + + +E S +EE KE
Sbjct: 745 SFM--NVKLLIQDLEDIEQR----VPVMDAQYKIITKTAHLITKE--SPQEEGKEMFATM 796
Query: 1487 KELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKM 1546
+L++ ++ + K +S S+++ E+L + + + L K + +
Sbjct: 797 SKLKEQLTKV-----------KECYSPLLYESQQLLIPLEELEKQMTSFYDSLGKINEII 845
Query: 1547 TDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGI 1606
T ER + + L E+ K+ G V++ + ++ ++
Sbjct: 846 TVLEREAQSSALFKQKHQELLACQENCKKTLTLIEKGSQSVQKFVTLSNVLKHFDQ---- 901
Query: 1607 CDLLTQTENRLIGHQEAFM-IGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFL 1665
T+ + ++ AF + T + KK+ L K + S L +V++ + L
Sbjct: 902 ----TRLQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMKKFEESRAELEKVLRIAQEGL 957
Query: 1666 KENGE-----KLSQEDKALIEQKLNEAKIK-CEQL-NLKAEQSKKELDKVVTTA------ 1712
+E G+ + E + ++Q++ A +K C++L ++ EQ ++ L + V
Sbjct: 958 EEKGDPEELLRRHTEFFSQLDQRVLNAFLKACDELTDILPEQEQQGLQEAVRKLHKQWKD 1017
Query: 1713 -----------IKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQN 1761
+K + EK + +EE +T+++ + + SE+ +H+
Sbjct: 1018 LQGEAPYHLLHLKIDVEKNRFLASVEECRTELDRETKLMP--QEGSEKIIKEHRVFFSDK 1075
Query: 1762 GTHFQEGDGKSAIGE-------EDEVNG-----NLLETDVDGQVGTTQENLNQQYQKVK- 1808
G H I E D V ++ ++ + +T L + K K
Sbjct: 1076 GPHHLCEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLKELRAAIDSTYRKLMEDPDKWKD 1135
Query: 1809 -----AQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEK---------EKLQKNMKEL 1854
++ IS ++ + + + G+ E+ E L L
Sbjct: 1136 YTSRFSEFSSWISTNETQLKGIKGEAIDTANHGEVKRAVEEIRNGVTKRGETLSWLKSRL 1195
Query: 1855 KVHYETA-----------LAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENL 1903
KV E + LA+ K +L E+EK +++ + + + + LE L
Sbjct: 1196 KVLTEVSSENEAQKQGDELAKLSSSFKALVTLLSEVEKMLSNFGDCVQYKEIVKNSLEEL 1255
Query: 1904 EAGADDINGLMTKLKRQKSFSED---VISHKGDLRYITISGNRVLEAAKSCSKRDGGKVD 1960
+G+ ++ K+ ++ E ++ H+ + I+ V + + +GG D
Sbjct: 1256 ISGSKEVQEQAEKILDTENLFEAQQLLLHHQQKTKRISAKKRDVQQQIAQAQQGEGGLPD 1315
Query: 1961 TSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEAT 2020
H E+ RKL+ D + ++ + K++ +E ++ L ++
Sbjct: 1316 RG--HEEL-RKLESTLDGLERSRERQE---RRIQVTLRKWERFETNKETVVRYLFQTGSS 1369
Query: 2021 ASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKL-KKTAEVLLDARGSLLPAKN 2079
+ LS ++L +LE+TK + S V E L K+ +E+ L + L
Sbjct: 1370 HERFLS---FSSLESLSSELEQTKEFSKRTESIAVQAENLVKEASEIPLGPQNKQL---- 1422
Query: 2080 DIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGN--------VE 2131
+ +KS+ E+ +KL+ TL + + + D G+ +
Sbjct: 1423 ------------LQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWIT 1470
Query: 2132 SSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQ 2191
KE + +S+A+ IS+ + Q+I + SSI + E+ + F + ++ ++
Sbjct: 1471 EKEKELNALETSSSAMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIK 1530
Query: 2192 AKMKDLSARFSEASHKHKETL--AKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVP 2249
AK+ + R+ E +H + L + L + + ENL + Q+ E + + + +
Sbjct: 1531 AKLTQI-RRYGEELREHAQCLEGTILGHLSQQQKFEENLRKIQQSVSEFEDKLAVPIKI- 1588
Query: 2250 GKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEK-TNNLSKKFK 2308
TE + +Q EH + L SL I++ + K + + + +
Sbjct: 1589 CSSATETYKVLQ-------EHMDLCQALESLSSAITAFSASARKVVNRDSCVQEAAALQQ 1641
Query: 2309 EMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKS---WIKETTKKVPIVQPSFGAEDLGKSL 2365
+ ED ++ KE T+ + L +Q L K L S W++ K + A
Sbjct: 1642 QYEDILRRAKERQTALENLLAHWQRLEKELSSFLTWLERGEAKASSPEMDISA------- 1694
Query: 2366 EDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNT 2425
D K++ + L IQ + N +S + S + +++ +V S
Sbjct: 1695 -DRVKVEGELQL----IQALQNEVVSQASFYSKLLQLKESLFSVAS-------------- 1735
Query: 2426 EEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQK 2485
+ +K + + + DL ++ +I L + +++ Q+ E + W+
Sbjct: 1736 -----KDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWI-- 1788
Query: 2486 MNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTEL--LEENPDT 2543
K QT + + + ++K AE++ ++Q L+ L +L L D
Sbjct: 1789 --KLFLSELQTTSEISIMDHQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAED- 1845
Query: 2544 PEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEE---SSNNLTQFQTVEAQLKQWLVEKEL 2600
L + K ++ QL + Q +E + ++L +F A L L ++L
Sbjct: 1846 ---------LHLLQGKAEDCFQLFEEASQVVERRQLALSHLAEFLQSHASLSGIL--RQL 1894
Query: 2601 MVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSR--------PGE 2652
+V S++ N + + + LQ E + GILS+ E
Sbjct: 1895 RQTVEATNSMNKNESDLIEKDLNDALQ----NAKALESAAVSLDGILSKAQYHLKIGSSE 1950
Query: 2653 DPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNK 2712
+ +QL ++ +L G D + A++K +Q L + D++ +
Sbjct: 1951 QRTSCRATADQLCGEVERIQNLLGTKQSEADAL--AVLKKA-FQDQKEELLKSIEDIEER 2007
Query: 2713 LSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSR 2772
A+ Q+L +++ E+ + ++ + + ++ K+ E+ R
Sbjct: 2008 TDKERLKEPTRQALQQRLRVFNQLEDELNSHEHELCWLKDKAKQIAQ--KDVAFAPEVDR 2065
Query: 2773 QLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAK 2832
++ + ++ D ++ + Q C +D +E QN +S
Sbjct: 2066 EINRLEVTWDDTKRL----IHENQGQCC-------------GLIDLMREYQNLKSAVSKV 2108
Query: 2833 LD------VLESLIKDHKD----FSKTLTAQSHMYEKT------IAEGENL---LLKTQG 2873
L+ V + IKD +D FSK TA++ M K ++G++L L K
Sbjct: 2109 LENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSELKKIHS 2168
Query: 2874 SEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLE 2933
S+ + ++ + + W +++++E ++L+ SL ++W +
Sbjct: 2169 SDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSL-----------SIW----------D 2207
Query: 2934 EIKFCLDPAEG--ENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENK 2991
++ D EG N + ++ +D H ELL E + EV +NK
Sbjct: 2208 DVLSTRDEIEGWSNNCVPQMAENISNLDNHLRAEELLK----------EFESEV---KNK 2254
Query: 2992 SLIQKVDMVTEQLHSKKFCLENMTQKFK---EFQEVSKESKRQLQCAKEQLDI-----HD 3043
+L E+LHSK L+ +T+ + + Q + + ++L+ AKE ++ D
Sbjct: 2255 AL------RLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEITEVAKGTLKD 2308
Query: 3044 SLGSQAYSNKYLTMLQT-------------QQKSLQALKHQVDLAKRLAQDLVVEASDSK 3090
K++ + T Q ++ +ALK D+ K L +S +
Sbjct: 2309 FTAQSTQVEKFINDITTWFTKVEESLMNCAQNETCEALKKVKDIQKELQSQQSNISSTQE 2368
Query: 3091 GTSDVLLQVET------------IAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMF 3138
+ + + + + ++H +SQ + + L+ L+ HF +++E
Sbjct: 2369 NLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLE--KHFSESMQEFQ 2426
Query: 3139 SQF-------AEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDN--ANKTC 3189
F E D + LQ +++ KL+A+ A+ +
Sbjct: 2427 EWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAVTQEGQTLYAHLSK 2486
Query: 3190 KMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSI 3249
+++ + +E + + +A KQC K ++ ++ L F + ++ ++
Sbjct: 2487 QIVSSIQE---QITKANEEFQAFLKQCLK-------DKQALQDCASELGSFEDQHRKLNL 2536
Query: 3250 LLQKAEE--HEESQGPVGMETETINQQLNMFKVF------QKEEIEPLQGKQQDVNWLGQ 3301
+ + EE + E+ G +++ ++F +E ++ L + Q ++ G
Sbjct: 2537 WIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLSEEGH 2596
Query: 3302 GLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSW 3361
G Q + +L R + Q A Q EAL ++AL+S+ W
Sbjct: 2597 GAGQEGRLCSQLLTSHQNL----LRMTKEKLRSCQVALQEHEAL------EEALQSMWFW 2646
Query: 3362 MVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPAD 3421
+ ++ +A + ++ ++ + + + + + + + + +GE+ ++
Sbjct: 2647 VKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAIGKGEQALRSSNKEG 2706
Query: 3422 KVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNC 3481
+ I QL L W +++ + LE + + E L +W+ ++++++ +
Sbjct: 2707 QRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKIEH- 2765
Query: 3482 EPIGTQASKLEEQIA--QHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLD 3539
P+ Q E+ + +++ + +H + LH+ I +S ++ ED+ + +
Sbjct: 2766 -PLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRL--IAKSRELYEKTEDESFKDTAQE 2822
Query: 3540 FSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEG 3599
+ + +I + + +++ + + ++ + E +WL+ ++L + S +
Sbjct: 2823 ELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDSSA 2882
Query: 3600 LWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKD--- 3656
K+ S+++ L + + + + E+ + TT ++ +++A++A +K
Sbjct: 2883 TQKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWED 2942
Query: 3657 ------------ITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVE-VELLSYETQV 3703
+++++ + Q QL + L L TW ++ +E + + ++
Sbjct: 2943 SVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQLTLLEGKNTDEEI 3002
Query: 3704 L----KGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAED 3759
+ KG+E A L+K + L LNE+ +L + + + ++ E
Sbjct: 3003 VECWHKGQEILDA------LQKAEPRTEDLKSQLNELCRFSRDLSTYSGK--VSGLIKEY 3054
Query: 3760 NERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTS 3819
N S K + + Q+F +A W+ + DI + S
Sbjct: 3055 NCLCLQASKGCQNKEQ------ILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVS 3108
Query: 3820 AQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQIN 3879
LQ + F E + ++ ++ G + T ++E+ + ++ K+ +++
Sbjct: 3109 TSLQKIQEFLSESENGQHKLNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNL 3168
Query: 3880 SERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRE 3939
++ LE + + F + E + WL++T+ ++ + + R++Q++ + + E
Sbjct: 3169 HQKESALENLKIQMKDFEVSAEPIQDWLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLE 3228
Query: 3940 LIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAIS 3999
I ++P ++++ + QL E S + + + Y + K++ LD ++
Sbjct: 3229 EIHCYEPQLNRLKEKAQQLWE-GQAASKSFRHRVSQLSSQYLALSNLTKEKVSRLDRIVA 3287
Query: 4000 QSTQF-------HDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKL 4052
+ QF D + + L+ + + K++ +S + + M
Sbjct: 3288 EHNQFSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQM--- 3344
Query: 4053 QPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENI-------HTLVEEREA 4105
+ + RGE ++ + +Q +L + +W ++ + +E +
Sbjct: 3345 ----KMIVTRGESVLQNTSPE----GIPTIQQQLQSVKDMWASLLSAGIRCKSQLEGALS 3396
Query: 4106 KLLDVMELAEKF--WCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEID 4163
K + +F W D M + +++ +L D A+ + EE+
Sbjct: 3397 KWTSYQDGVRQFSGWMDSME--ANLNESERQHAELRDK-------TTMLGKAKLLNEEVL 3447
Query: 4164 GLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAA 4223
L+ + + G + + + + +L + ++ + K+ + K E+ ++
Sbjct: 3448 SYSSLLETI------EVKGAGMTEHYVTQLELQDLQERYRAIQERAKEAVTKSEKLVRLH 3501
Query: 4224 VQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNH 4283
+YQ L+A W+ KL S + D T + + +L++ + + Q + + H
Sbjct: 3502 QEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVLH 3561
Query: 4284 QAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDEL 4343
E ++ +++ ++ L+ W + + R+ + + + L + ++
Sbjct: 3562 TREDVIPSGIPQAEDRALE----SLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQV 3617
Query: 4344 LAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSA 4403
WL + A+ +V A++ VE V ++++ S
Sbjct: 3618 DEWL----------------------KTAEEKKWHEEVTAYRDEVEEVGARAQEILDES- 3654
Query: 4404 GEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHL 4463
S + + L R+Q +L + ++ + L+ ++ + + W T ++
Sbjct: 3655 -HVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNF 3713
Query: 4464 --LASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQ 4521
+A+K ++L + E KS +KG++ + + + +
Sbjct: 3714 KNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGEAERLRK 3773
Query: 4522 DINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLI 4581
+I++ E+ + + + + + LE+ L+LA EF + + W+ + ++ L+V P +
Sbjct: 3774 EIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKME 3833
Query: 4582 LDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHL--------------KYFSQKQDVVL 4627
L Q+ ++K V SH + + + G L + S QD+
Sbjct: 3834 LYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLELVQDVTLKDKIDQLQSDYQDLCS 3893
Query: 4628 IKNLLISVQSRWEKVVQRLVERGRSL-----DDARKRAKQ--------FHEAWSKLMEWL 4674
I ++ + +E + L +G +L D + + KQ +++S +
Sbjct: 3894 IGKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTA 3953
Query: 4675 EESEKSLDSELE-IANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLAD 4733
+ +SL+ EL+ + D ++ A Q L + + +K +L +
Sbjct: 3954 QRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRALQE 4013
Query: 4734 DNLKLDDMLSELRD----KWDTICGKSVERQNKLEEALLFSGQFTDALQALID-----WL 4784
D+L + D T + + +E+ L+ + T + + W+
Sbjct: 4014 QARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQKLVQAQNLTQGWEEIKHLKSELWI 4073
Query: 4785 Y--RVEPQLAEDQPVHGDIDL--VMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSR 4840
Y + QL + H +++L N++ K F K+L + +SV + +L ++
Sbjct: 4074 YLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKL---TK 4130
Query: 4841 DDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLR 4900
+ S ++ L+ +W +C S + + E L++ ++H ++ + +L + T
Sbjct: 4131 KEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFLEKF--TTE 4188
Query: 4901 FHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWIT 4960
+ + D ++ ++ K+ L+E++ + ++ + D +K +
Sbjct: 4189 WDNLARSDAESTAVHLEALKKLALALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTS 4248
Query: 4961 IIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEI 5020
+ R+ ++ K+ Q + L L Q + L+ W + + + + K+ P ++
Sbjct: 4249 HLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDM 4308
Query: 5021 EEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRRAAD 5057
+ L+ +H E+ KQ + + K R AD
Sbjct: 4309 --AQNLLMDHLAICSELEAKQMLLKSLIKDADRVMAD 4343
Score = 271 bits (694), Expect = 1e-71
Identities = 876/4843 (18%), Positives = 1865/4843 (38%), Gaps = 750/4843 (15%)
Query: 723 QYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHA 782
Q A+ ++ N R + L F S N+ + L E + D E N+ D
Sbjct: 2226 QMAENISNLDNHLRAEELLKEFESEVKNKALRLEELHSK--VNDLKELTKNLETPPDLQF 2283
Query: 783 ELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQ-LCQCVEQHI 841
+ +L QK E+ K + E+A+ L + +E + + T ++ + + L C +
Sbjct: 2284 -IEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCAQ--- 2339
Query: 842 KENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYK 901
N+ EA +++++ +Q + S + SS+ L L ++ Y
Sbjct: 2340 ----------NETCEALKKVKDIQKELQSQQS-NISSTQENLNSLCRK----------YH 2378
Query: 902 STIANLMGKAKT-IIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRA 960
S +G+A T +I+ S KT ++ + + ++ + E L + A
Sbjct: 2379 SAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLE-KHFSESMQEFQEWFLGAKA--A 2435
Query: 961 KWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWH 1020
+ TG+ ++ + + D ++++ Q TL+ +H++ + V S
Sbjct: 2436 AKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAVTQEGQTLY--AHLSKQIVSS-- 2491
Query: 1021 YLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVF----------- 1069
+ +I + A +K L + +Q L + S F + ++ ++
Sbjct: 2492 -IQEQITKANEEFQAFLKQCL--KDKQALQDCASELGSFEDQHRKLNLWIHEMEERFNTE 2548
Query: 1070 ----SGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDR 1125
S I + + EV+ + + ELL + E ++ L E E R
Sbjct: 2549 NLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLSEEGHGA-----GQEGR 2603
Query: 1126 LIRQIRTPLERDDLHESVFRITEQEKLK------KELERLKDDLGTITNKCEEFFSQAAA 1179
L Q+ T H+++ R+T+ EKL+ +E E L++ L ++ + + A
Sbjct: 2604 LCSQLLTS------HQNLLRMTK-EKLRSCQVALQEHEALEEALQSMWFWVKAIQDRLAC 2656
Query: 1180 SSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVK----LYETKL 1235
+ S + L L + + M KL + K QA + K + +T+L
Sbjct: 2657 AESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMA--IGKGEQALRSSNKEGQRVIQTQL 2714
Query: 1236 CEEEAVIAD--------KNNIENLIST----------LKQWRSEVDEKRQVFHALE---- 1273
+ V AD ++ +E++IS L+QW VD+K + H L+
Sbjct: 2715 ETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQK--IEHPLQPQPG 2772
Query: 1274 --------DELQKAKAISDEMFKTY-----KERDL-----DFDWHKEKADQLVERWQNVH 1315
D LQ + +++ + K R+L D + ++L ++ ++
Sbjct: 2773 LKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQEELKTQFNDIM 2832
Query: 1316 VQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKT------LAT 1369
++R +E I K Y D H DW+ + + + ++S T +
Sbjct: 2833 TVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDSSATQKKLSKIKE 2892
Query: 1370 QLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMT--YRAMVDSQQKSPVKRR 1427
++ +++ S + +S E ++ + E+Q + ++ DS ++
Sbjct: 2893 LIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQSCLE 2952
Query: 1428 RMQSSADLIIQEFM-------DLRTRYTALVTLMTQYIKFAG------------------ 1462
+ S L QEF +++AL+ Q +
Sbjct: 2953 NLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQLTLLEGKNTDEEIVECWHKGQEI 3012
Query: 1463 -DSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAE----KAGKPPFSKQKIS 1517
D+L++ E + L+ + E +++L + +S +K+ +A K +K++I
Sbjct: 3013 LDALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQIL 3072
Query: 1518 SE----------------EISTKK--------EQLSEALQTIQLFLAKHGDK-------- 1545
+ +I+T K ++S +LQ IQ FL++ +
Sbjct: 3073 QQRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMML 3132
Query: 1546 ---------MTDEERNELEKQVKTLQESYNLLFS---------ESLK-QLQESQTSGD-- 1584
+T E+ ++ +V +E + S E+LK Q+++ + S +
Sbjct: 3133 SKGELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPI 3192
Query: 1585 ---VKVEEKIVAER---------QQEYKEKLQGICDLLTQTE---NRLIGHQEAFMIGDG 1629
+ EK+V E ++ ++KLQ + + + E NRL ++A + +G
Sbjct: 3193 QDWLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRL--KEKAQQLWEG 3250
Query: 1630 TVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKEN-----GEKLSQE--------- 1675
K ++ + +L + E V + + E+ G K Q+
Sbjct: 3251 QAASKSFRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAIHML 3310
Query: 1676 --------DKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVA--AVKQ 1725
DK++++ + +K E L L +Q K+ K++ T + + + +
Sbjct: 3311 DSYCHPTSDKSVLDSRT----LKLEAL-LSVKQEKEIQMKMIVTRGESVLQNTSPEGIPT 3365
Query: 1726 LEESKTKIENLLDWLSNVDKDSERAGTKHKQVIE---QNGTHFQEGDGKSAIGEEDEVNG 1782
+++ ++++ W S + AG + K +E T +Q+G + + G D +
Sbjct: 3366 IQQQLQSVKDM--WASLLS-----AGIRCKSQLEGALSKWTSYQDGVRQFS-GWMDSMEA 3417
Query: 1783 NLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPE 1842
NL E++ + + K K +E+++S + + E Y++
Sbjct: 3418 NLNESE---RQHAELRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTE---HYVTQL 3471
Query: 1843 EKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELEN 1902
E + LQ+ + ++ + A+ +SEK ++L Q +L+ F+ WL Q +++L+
Sbjct: 3472 ELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEV-------WLGQEQEKLDQ 3524
Query: 1903 ---LEAGAD-------DINGLMTKLKRQKSFSEDVISHKGDL--RYITISGNRVLEAAKS 1950
LE A D+ L ++ V+ + D+ I + +R LE+ +
Sbjct: 3525 YSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALESLRQ 3584
Query: 1951 CSKRDGGKVDTSA-THR--EVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDAS 2007
D A HR E + + ++ ++ R + K + LK +K H E +
Sbjct: 3585 ---------DWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKKWHEEVTA 3635
Query: 2008 CG---LLAGLQACEATASKHLSEPIAVDPKNLQRQ--------LEETKALQGQISSQQ-- 2054
G +A E H++ + L + LE+ K L+ +I S +
Sbjct: 3636 YRDEVEEVGARAQEILDESHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEES 3695
Query: 2055 ------------------------------VAVEKLKKTAEVLL---DARGSLLPAKND- 2080
V + K KT EVLL + SLL + +
Sbjct: 3696 ESSLSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREK 3755
Query: 2081 ---------------IQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLD 2125
++K + D + + ++L+ +V + + L+ L + D +
Sbjct: 3756 GERAVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQ 3815
Query: 2126 WMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPS 2185
W+ + L + + + +SK L+Q + + S+ ++ EK + +E
Sbjct: 3816 WIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLELVQDV 3875
Query: 2186 TASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTF-------LET 2238
T L+ K+ L + + + K A MEE+ + NL K T L+
Sbjct: 3876 T---LKDKIDQLQSDYQDLCSIGK---AMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQA 3929
Query: 2239 KTQALTEVDVPG-KD----VTELSQYMQESTSEFLEHK--KH------LEVLHSLLKEIS 2285
K + + G KD + +Q M +S LEH+ KH L+ + L +
Sbjct: 3930 KLKQNVHAHLQGTKDSYSAICSTAQRMYQS----LEHELQKHVSRQDTLQQCQAWLSAVQ 3985
Query: 2286 SHGLPSDKA-LVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKE 2344
PS + L + K F+ +++ + + + S D VK+ I++
Sbjct: 3986 PDLEPSPQPPLSRAEAIKQVKHFRALQEQARTYLDLLCS---MCDLSNASVKTTAKDIQQ 4042
Query: 2345 TTKKVPIVQPSFGAEDLGKSLEDTKKLQ-EKWSLKTPEIQKVNN-----SGISLC---NL 2395
T + + Q A++L + E+ K L+ E W Q++ N S + L N+
Sbjct: 4043 TEQTIE--QKLVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNM 4100
Query: 2396 ISAVTTPAKAIAAVKSG-GAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLL 2454
+S V K + + ++ ++ T EE +K + + D+ +L L
Sbjct: 4101 VSQVKDFVKKLQSKQASVNTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCLQ 4160
Query: 2455 LKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKS 2514
++ LQ+ ++ M + K T+W A +D E+ +E K
Sbjct: 4161 REED----------LQRTRDYHDCMNVVEVFLEKFTTEWDNL-ARSDAESTAVHLEALKK 4209
Query: 2515 FEAELKQNVNKVQELKDKLTELLEE-NPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQK 2573
L++ +++LKD+ +++E N D E K+ + ++ +W +L L ++K
Sbjct: 4210 LALALQERKYAIEDLKDQKQKMIEHLNLDDKELV--KEQTSHLEQRWFQLEDLI---KRK 4264
Query: 2574 LEESSNNLTQFQTVEA---QLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFA 2630
++ S NL + V++ +L +W E++ ++ S P+M + E
Sbjct: 4265 IQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICSELE 4324
Query: 2631 TRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIV 2690
++ + L +++ G + R ++++ L+ + L+ + R ++++A+
Sbjct: 4325 AKQMLLKSLIKDADRVMADLGLNE--RQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALS 4382
Query: 2691 KSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVA 2750
+ TQ+ + + ++ + K+ + PD +++Q++T + + ++ + ++
Sbjct: 4383 EKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQNEVTGL 4442
Query: 2751 QALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSR 2810
A +L V E+ K+E+ +L+ + + V QK + +Q L+ S F++
Sbjct: 4443 WAQGRELMKEVTEQE-KSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKE--- 4498
Query: 2811 DFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSK--TLTAQSHMYEKTI----AEG 2864
DF K+ + P +++++ + H +K + QS YE + G
Sbjct: 4499 DFDKACHWLKQADIVTFP---EINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTG 4555
Query: 2865 ENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPW 2924
+ +L + + L +LN + ++ K++ K++E++ +Y +E
Sbjct: 4556 QTILPSLNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLIELTTQS 4615
Query: 2925 IDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKE 2984
+ + + + E +++ + +D+ G+ E ++ +
Sbjct: 4616 LSELEAQFLRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVDELNQKKEGFRSTGQP 4675
Query: 2985 VVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLD--IH 3042
D+ L+ + Q + LE+ T ++E +++ ++ +RQL+ KE+
Sbjct: 4676 WQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNE 4735
Query: 3043 DSLGSQAYSNKYLTMLQTQQKSLQALK----HQVDLAKRLAQDLVVEASDSKGTSDVLLQ 3098
++L ++ Y ++ + Q S LK H DLA L D Q
Sbjct: 4736 ETLPAEEKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHL---------DPLAYEKARHQ 4786
Query: 3099 VETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELD-------SM 3151
+++ E L+ + E + E+++ FQ + EL ++
Sbjct: 4787 IQSWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELSGPVYLDLNL 4846
Query: 3152 APVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEA 3211
+ + +Q +E +++ L+ + AL S+ K K A E S DL + L
Sbjct: 4847 QDIQEEIRKIQIHQEEVQSSLRIMNAL--SHKEKEKFTK---AKELISADL---EHSLAE 4898
Query: 3212 LSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETI 3271
LS+ + + + R+ + + + +Y + + L+ A+E + G G++ E+
Sbjct: 4899 LSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGN-GLDVESA 4957
Query: 3272 NQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLN 3331
+ L F E + ++++ L + K T + LE + + R + ++
Sbjct: 4958 EENLKSHMEFFSTE-DQFHSNLEELHSL-VATLDPLIKPTGKEDLEQKVASLELRSQRMS 5015
Query: 3332 KKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKA------- 3384
+ + LQ +Q A E ++ M DTE+ + +EF ++K
Sbjct: 5016 RDSGAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKL-------SEFSLLKTSSSHEAE 5068
Query: 3385 -QIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKA 3443
++ E K L +++ + ++ + ++ T A K + + ++ + RW L A
Sbjct: 5069 EKLSEHKALVSVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVA 5128
Query: 3444 ETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALED 3503
+ + + LE F+ ++ E + ++ +L ++L + H
Sbjct: 5129 QDQEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVL 5188
Query: 3504 DIINHNKHL----HQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELL 3559
++ L Q +S+ Q + E+ ++Q ++ Q + +QEK + +L+
Sbjct: 5189 ELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQ-EITAMQDRCLNMQEKVKTNGKLV 5247
Query: 3560 QQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQ 3619
+Q L + ++ + W+ E + L +++ + Q EL++L + +Q
Sbjct: 5248 KQELKDREMVETQINSVKCWVQETKEYLGNPTIE------IDAQLEELQILLTEATNHRQ 5301
Query: 3620 NVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLH 3679
N+++ E K+ I+ +L A L + ++ ++ +
Sbjct: 5302 NIEKM----AEEQKEKYLGLYTILPSELSLQLAE----VALDLKIRDQIQDKIKEVEQSK 5353
Query: 3680 STHEELCTWLDKVEVELLSYETQV-LKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSS 3738
+T +EL + K+ +L + T++ K + QA+ K L +E + L L+
Sbjct: 5354 ATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQ 5413
Query: 3739 ALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWI 3798
LE + + L K + + E ++ ++ +++ A +++++ + L WI
Sbjct: 5414 KFLE-QNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWI 5472
Query: 3799 TETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRH-KDIIDDLVKSGHKIMTACSEEE 3857
+ K+++ G I +++QL+ Q +L K+I +L K+ S
Sbjct: 5473 EKA--KVLAHGTIAW---NSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVYC 5527
Query: 3858 KQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQL 3917
+ M +++ ++ + + + Q+ R L+ A + +F ++L L + Q + L
Sbjct: 5528 TEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQ---ATL 5584
Query: 3918 PAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAAD 3977
+P + +L++Q + L + KP + + QL + I E VA+
Sbjct: 5585 TSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAV-----QLCQ----SALRIPEDVVASL 5635
Query: 3978 TL----------YSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPS 4027
L S+++ ++ + A+ Q Q+ ++ + + +E + P
Sbjct: 5636 PLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPV 5695
Query: 4028 ISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLD 4087
++ +++++ QIS ++ ++ ++ Q E IA K ++ KA +
Sbjct: 5696 ATSNIQELQAQISRHEELAQKIKGYQ-----------EQIASLNSKCKMLTMKAKHATML 5744
Query: 4088 QMVFIWENIHTLVEEREAKLLD--------VMELAEKFWCDHMSLIVTIKDTQDFIR-DL 4138
V E + E+ + +LL VM A + C + VT + ++ ++
Sbjct: 5745 LTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGR--CHTLLSPVTEESGEEGTNSEI 5802
Query: 4139 EDPGI--DPSVVKQ-----QQEAAETIREEIDGLQEELDIVINLGSELIAACGEPD-KPI 4190
P PS V Q+ A + LQ + I+ + EP +P
Sbjct: 5803 SSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDA-AKIHPSTSASQEFYEPGLEPS 5861
Query: 4191 VKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPI 4250
+ +L +W++L ++ L EA++ +YQD LQ++ ++ KL+
Sbjct: 5862 ATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEP 5921
Query: 4251 GTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQ-AELLLKKVTE--ESDKHTVQDPLME 4307
G E+ Q+ E + E Q E+ L AE L+ + E +++ +Q L
Sbjct: 5922 GRSPES---QMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTV 5978
Query: 4308 LKLIWDSLEERIINRQHKLEGAL----------LALGQFQHALDELLAWLTHTEGLLSEQ 4357
L ++ + ++ LE L AL +++ DEL +WL T+ L
Sbjct: 5979 LAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTA 6038
Query: 4358 KPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAG----NDLIESSA--GEEASNLQ 4411
+P +E +L QN ++ + V A+++ N L+E A +EA L
Sbjct: 6039 LSPPKEPMDMEAQLMD---CQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLA 6095
Query: 4412 NKLEVLN------QR----WQNVLEKTEQRK---------------------------QQ 4434
KL L QR Q ++ T Q K QQ
Sbjct: 6096 GKLRRLKGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQ 6155
Query: 4435 LDGALRQAKGFHGEIEDLQQWLTDT---------------------ERHLLASKPLG--G 4471
+L+Q K E+ + + L E+ + S+ LG G
Sbjct: 6156 RQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEG 6215
Query: 4472 LPETAKEQLNVHME-VCAAFEAKEETYKSLMQKGQQ---------MLARCP--------- 4512
+A++Q+ + E + F K++ ++++++ Q+ +L+ P
Sbjct: 6216 EKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQ 6275
Query: 4513 -KSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQT 4571
KSA T++ ++ L + +E V ++ K ++++L + ++ + WL E+
Sbjct: 6276 DKSAVTSL---LDGLNQAFEEVSSQSGGAK---RQSIHLEQKLYDGVSATSTWLDDVEER 6329
Query: 4572 LNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQ-------KQD 4624
L VA+ +L+ + + ++ A ++ +E E+DK + FSQ +D
Sbjct: 6330 LFVAT--ALLPEETETCLFNQEILAKDI---KEMSEEMDK---NKNLFSQAFPENGDNRD 6381
Query: 4625 VVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSE 4684
V I++ L + R + + +R + + ++ F L L +++ + +
Sbjct: 6382 V--IEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQK 6439
Query: 4685 L------EIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKL 4738
L +A + I+ KEF + + R + E+ S+ +
Sbjct: 6440 LANVFEQPVAEQIEAIQQAEDGLKEFDA------GIIELKRRGDKLQVEQPSMQE----- 6488
Query: 4739 DDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQP-V 4797
LS+L+D +D + R++ L + L Q+ ALQ L D L + ++A DQ +
Sbjct: 6489 ---LSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKII 6545
Query: 4798 HGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRW 4857
+ + L+D HK + + L + L R++I + + EL +
Sbjct: 6546 VSSKEEIQQLLDKHKEYFQGLESHMILTETL---FRKIISFAVQKETQFHT---ELMAQA 6599
Query: 4858 ETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLID 4917
V + + LE L L L E ++ G++ ++ED L I
Sbjct: 6600 SAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRIT 6659
Query: 4918 QHKEFMKKLEEKRAELNKATTMGDTVL-AICHPDSITTIKH----WITIIRARFEEVLAW 4972
++ L E + +L + G +L +I D + + W++ +E+
Sbjct: 6660 LYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKEL--- 6716
Query: 4973 AKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLT--DKDKEVIPQEIEEVKALIAEH 5030
RL + L Q L+ WLQ A+ L + +PQE+E V+ +
Sbjct: 6717 -----HRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAF 6771
Query: 5031 QTFMEEMTRKQPDVDKVTKT----YKRRAADPSSLQSHIPVLD 5069
F +E+ + V T + + D ++L+S + +D
Sbjct: 6772 LEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELSRID 6814
Score = 270 bits (691), Expect = 2e-71
Identities = 771/4190 (18%), Positives = 1619/4190 (38%), Gaps = 553/4190 (13%)
Query: 671 LPSVESHLENHKNVHRAIEEFESSLKE--AKISEIQMTAPLKLT-YAEKLHRLESQYAKL 727
L S + H+ + + +E S+KE +K++E + A KL Y L+ L
Sbjct: 4702 LEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNEETLPAEEKLKMYHSLAGSLQDSGIVL 4761
Query: 728 LNTSRNQER---HLDTLHNFVSRATNEL-IWLNEKE--EEEVAYDWSERNTNIARKKDYH 781
+ + E HLD L +A +++ W E + + +E + + + D+
Sbjct: 4762 KRVTIHLEDLAPHLDPLA--YEKARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQ 4819
Query: 782 AELMRELDQKEE-------------NIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWS 828
E+ R LD N++ +QE ++ + + ++ A +
Sbjct: 4820 TEMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKE 4879
Query: 829 WILQLCQCVEQHIKENTAYF-EFFNDAKEATDYLRNLKDAIQRKYS-CDRSSSIHKLEDL 886
+ + + ++ + A E D +EA LR + + YS C R +++
Sbjct: 4880 KFTKAKELISADLEHSLAELSELDGDIQEA---LRTRQATLTEIYSQCQR---YYQVFQA 4933
Query: 887 VQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIY 946
+ +E+ +ELLQ L G L +++ LK+ + + D Q +
Sbjct: 4934 ANDWLEDAQELLQ-------LAGNG-----LDVESAEENLKSHMEFFSTED--QFHSNLE 4979
Query: 947 KDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLW 1006
+ V + +I PTG E + V + + D +++ Q W
Sbjct: 4980 ELHSLVATLDP------LIKPTGKEDLEQKVASLELRSQRMSRDSGAQVDL-LQRCTAQW 5032
Query: 1007 HESHINMKSVVSWHYLINEIDRIRASNVASIKTMLP-------GEHQQVLSNLQSRFEDF 1059
H+ + V+ L+N+ ++ + S + +KT EH+ ++S + S E
Sbjct: 5033 HDYQKAREEVIE---LMNDTEK-KLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKI 5088
Query: 1060 --LEDSQESQVFSGSDITQ--LEKEVNVCKQYYQELLKSAEREEQ--EESV--YNLYISE 1111
LE+ +G+D ++ L + + Q + L A+ +E+ E++V + + ++
Sbjct: 5089 VALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNK 5148
Query: 1112 VRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCE 1171
V+ ++ +D+L + E+ E + + + ELE+ + LG + +
Sbjct: 5149 VKKATEMIDQLQDKLPG---SSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTL 5205
Query: 1172 EFFSQAAASS--SVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVK 1229
AA + P L E+ + ++ +M K V LK+ + E +
Sbjct: 5206 SMLQDGAAPTPGEEPPLMQEITAM---QDRCLNMQEKVKTNGKLVKQELKDREMVETQIN 5262
Query: 1230 LYETKLCEEEAVIADKN-NIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAIS----- 1283
+ + E + + + I+ + L+ +E RQ + +E QK K +
Sbjct: 5263 SVKCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAEE-QKEKYLGLYTIL 5321
Query: 1284 -DEMFKTYKERDLDFDWHKEKADQLVE------RWQNVHVQIDNRLRDLEGIGKSLKYYR 1336
E+ E LD + D++ E Q + QI +DL I LK
Sbjct: 5322 PSELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKT 5381
Query: 1337 DTYHPLDDWIQQVETTQRKIQENQPE-NSKTLATQLNQQKMLVSEIEMKQSKMDECQKYA 1395
D + Q +T Q+ + E NSK + QK L ++ + + K
Sbjct: 5382 DN-------VVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLT 5434
Query: 1396 EQYSATVKDYELQTMT----------YRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRT 1445
E + T++ E + Y M++ K +++ ++ + + LR
Sbjct: 5435 ELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKW-IEKAKVLAHGTIAWNSASQLRE 5493
Query: 1446 RYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEK 1505
+Y TL+ EE K ++ E + EK + L + + AE
Sbjct: 5494 QYILHQTLL---------------EESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAEL 5538
Query: 1506 AGKPPFSKQKI-----SSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKT 1560
+ +Q I + ++ + ++ L+ +Q L + +T E L + +
Sbjct: 5539 GRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQL 5598
Query: 1561 LQESYNLLFSESLK-QLQESQT-SGDVKVEEKIVAERQQEYKEKLQGICD--LLTQTENR 1616
+ L ESLK ++Q Q +++ E +VA +C L Q E
Sbjct: 5599 SHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLP---------LCHAALRLQEEAS 5649
Query: 1617 LIGH---QEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLK-----EN 1668
+ H Q+ ++ V+ ++Y+ + + LQ+ ++G+ + + + T N +
Sbjct: 5650 RLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQISR 5709
Query: 1669 GEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEE 1728
E+L+Q+ K EQ + KC+ L +KA+ + L + E TE +
Sbjct: 5710 HEELAQKIKGYQEQ-IASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTP 5768
Query: 1729 SKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETD 1788
S S V + R T V E++G +EG S I
Sbjct: 5769 SAHP--------SVVMMTAGRCHTLLSPVTEESG---EEGTN-SEISSPPACRS------ 5810
Query: 1789 VDGQVGTTQENLNQQ---YQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKE 1845
V T ++NQ YQ + A E++ + + +T ++Q E + + +
Sbjct: 5811 -PSPVANTDASVNQDIAYYQALSA--ERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLG 5867
Query: 1846 KLQKNMKELK--------VHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSE 1897
LQ++ + LK YE AL +K S+ ++E + +E + E
Sbjct: 5868 DLQRSWETLKNVISEKQRTLYE-ALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPE 5926
Query: 1898 QELENLEAGADDINGLMTKLKR-QKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDG 1956
++ +A D+I L ++ Q S +E+++S +SC
Sbjct: 5927 SQMAEHQALMDEILMLQDEINELQSSLAEELVS-------------------ESCEADPA 5967
Query: 1957 GKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKY------QHYEDASCGL 2010
++ +T + ++ +T R ++ K +L L D +++ Q Y + L
Sbjct: 5968 EQLALQSTLTVLAERM--STIRMKAS-GKRQLLEEKLNDQLEEQRQEQALQRYRCEADEL 6024
Query: 2011 LAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAE-VLLD 2069
+ L + +AT LS P +P +++ QL + + + +I + VA+ +L E +LL+
Sbjct: 6025 DSWLLSTKATLDTALSPP--KEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLE 6082
Query: 2070 ARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQ------------ITLTRSLSVQ 2117
+ + L + G +L ++++++ +Q +T T+S VQ
Sbjct: 6083 GKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQ 6142
Query: 2118 DGLDEM-LDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVK 2176
+ L + W +SSL++Q + L+ +++ L + +A R I + +
Sbjct: 6143 EWLAQARTTWTQQRQSSLQQQKE-------LEQELAEQKSLLRSVASRGEEILIQHSAAE 6195
Query: 2177 KFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENL--SEKLQT 2234
+ + S + M+ + + E+L +E TK +L +N+ E+ Q
Sbjct: 6196 TSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESLH--QEFSTKQKLLQNVLEQEQEQV 6253
Query: 2235 FLETKTQALTEV-----DVPGKDVTE-------LSQYMQESTSEFLEHKKHLEVLHSLLK 2282
+ L+ V DVP +D + L+Q +E +S+ K+ L L
Sbjct: 6254 LYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLY 6313
Query: 2283 E-----------------ISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSC- 2324
+ +++ LP + L L+K KEM + + + K +
Sbjct: 6314 DGVSATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAF 6373
Query: 2325 QEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQK 2384
E D V+ +L + + +V + + L+ Q LK
Sbjct: 6374 PENGDNRDVIEDTLGCLLGRLSLLDSVVNQR--CHQMKERLQQILNFQN--DLKVLFTSL 6429
Query: 2385 VNNSGISLCNLISAVTTP-AKAIAAVK----------SGGAVLNGEGTATNTEEFWANKG 2433
+N I L L + P A+ I A++ +G L G E+
Sbjct: 6430 ADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQ------ 6483
Query: 2434 LTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKW 2493
++++ + Y++L +++ + + LN L+ L+ E + + L + +
Sbjct: 6484 --PSMQELSKLQDMYDELMMIIGSRRSGLNQNLT-LKSQYERALQDLADLLETGQEKMAG 6540
Query: 2494 QQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQML 2553
Q + E ++ ++++K + L+ ++ + L K+ + Q
Sbjct: 6541 DQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKET--------QFH 6592
Query: 2554 TEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPN 2613
TE+ ++ + + R +LE + + +L + L E + +G + + +
Sbjct: 6593 TELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENED 6652
Query: 2614 MLNTQRQQVQILLQEFATRKPQYEQLTAAGQGIL-SRPGEDPSLRGIVKEQLAAVTQKWD 2672
L + Q L +P+ Q+ G+ +L S D ++ QL + + W
Sbjct: 6653 RLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSD------LESQLNQLGECWL 6706
Query: 2673 SLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLS----SSLAVSTHPDAMNQ 2728
S T ++S ++ + T+YQS L L ++L S+ V + +
Sbjct: 6707 SNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRD 6766
Query: 2729 QLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEY--LKAELSR---QLEGILKSFKD 2783
L + +E+ + + L L K + L++ELSR Q +L +
Sbjct: 6767 HLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPA 6826
Query: 2784 VEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDT-----KKEEQNKSHPISAKLDVLES 2838
V++K Q S H ++ +W+ +K+E N + I K +
Sbjct: 6827 VQEKLH---QLQMDKLPSRHAISEV----MSWISLMENVIQKDEDNIKNSIGYK--AIHE 6877
Query: 2839 LIKDHKDFSKTLTAQS---HMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNK 2895
++ +K F + + +++ + + ++++ S+K QL + +W
Sbjct: 6878 YLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQG 6937
Query: 2896 QVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQ 2955
V E+ L+ LE +Y+ V+ L W + + L++ D A +N++ + L+
Sbjct: 6938 LVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLE 6997
Query: 2956 KEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQ-KVDMVTEQLHSKKFCLENM 3014
L+ E + E + +LIQ K + V+ + S L +
Sbjct: 6998 ------------------DLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMST---LREL 7036
Query: 3015 TQKFKEFQEVSKESKRQLQCAKEQLDIH----DSLGSQAYSNKY-LTMLQTQQKSLQALK 3069
Q + + + K L+ +Q H D + S +Y L+ + SL+A++
Sbjct: 7037 GQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQ 7096
Query: 3070 HQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKC-----SFLETKL 3124
QVD + L DL + E Q+ +++ Q+ ++C L L
Sbjct: 7097 VQVDNLQNLQDDLEKQ--------------ERSLQKFGSITNQLLKECHPPVTETLTNTL 7142
Query: 3125 QGIGHFQNTIREMFSQFAEFDDELDSMAPVGRD-----AETLQKQKETIKAFLKKLEALM 3179
+ + N + E ++ + L + +D A T+Q+Q++ LK
Sbjct: 7143 KEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKD 7202
Query: 3180 ASNDNAN---KTCKMMLATEETSPDLV--------------------GIKRDLEALSKQC 3216
++D + C +L T D + I+ D +LS+
Sbjct: 7203 IADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHL 7262
Query: 3217 NKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPV-GMETETINQQL 3275
L ++ ++ + E F L+ + +AEE + Q P + TI +++
Sbjct: 7263 CALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERM 7322
Query: 3276 NMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVA 3335
K Q + + +N LG L + + Q L N W ++ +
Sbjct: 7323 EELKG-QMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNL-------NRHWSLISSQTT 7374
Query: 3336 QRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRL 3395
+R ++LQ LL F + E+ + ++V TE+ +A + S ++ + Q + +L Q
Sbjct: 7375 ERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEI--SGNYQHLLEQQRAHELFQAE 7432
Query: 3396 LDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISV 3455
+ R+ + I +G+++ + D+ + +L+LL ++W+ ++ +A+ R ++
Sbjct: 7433 MFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIR 7492
Query: 3456 VAQQFHETLEPLNEWLTTIEKRLVN---CEPIGTQASKLEEQIAQHKALEDDIINHNKHL 3512
Q++ E E L +WL + ++ PI Q ++ Q K E +
Sbjct: 7493 QWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFK--EKVFLRQQGSY 7550
Query: 3513 HQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGED 3572
V G+ L + + + +Q++L EIQEK S S L++ +D
Sbjct: 7551 ILTVEAGKQLLLSADSGAEAALQAEL-------AEIQEKWKSASMRLEEQKKKLAFLLKD 7603
Query: 3573 EVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQAL------L 3626
+ + + +KL + ++ L EL Q +R + ++ A+ L
Sbjct: 7604 WEKCEKGIADSLEKLRTFKKK--LSQSLPDHHEELHAEQ----MRCKELENAVGSWTDDL 7657
Query: 3627 NGLELLKQT-----TGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHST 3681
L LLK T + D++ I+ +++E ++ +++++ + + + + L
Sbjct: 7658 TQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEK 7717
Query: 3682 HEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALL 3741
++ELC WL ++E ++ S +L E + + +E A+ NK L + E L
Sbjct: 7718 NKELCEWLTQMESKV-SQNGDILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGE---RLA 7773
Query: 3742 ELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITET 3801
+ +E + + N+R++ + D I +V+++ ++ QQ D+ + +W+
Sbjct: 7774 KASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHI 7833
Query: 3802 EKKLMS-LGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTAC----SEE 3856
E +L + ++ +L Q+ +I +H + ++ ++ C ++
Sbjct: 7834 ESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDA 7893
Query: 3857 EKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQ 3916
E S+++ + + + IC ++ ER L++E L +F + Y WL ++ +
Sbjct: 7894 ECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAF 7953
Query: 3917 LPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLL-ELSPGEGFSIQEKYVA 3975
+ + Y +++ ++ + + E ++ +NK +L E S+++
Sbjct: 7954 PSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHE 8013
Query: 3976 ADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSIS-AEVE- 4033
+ + +++ V L I Q +F D IL L + +L S +V+
Sbjct: 8014 GNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQA 8073
Query: 4034 KIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIW 4093
KIK+ + + +S++ K+ E + +GE++I +S + + A ++++LD++
Sbjct: 8074 KIKQLKAFQQEISLNHNKI----EQIIAQGEQLIEKS----EPLDAAIIEEELDELRRYC 8125
Query: 4094 ENIHTLVE-------------------EREAKLLDVMELAEKFWCDHMS-LIVTIKDTQD 4133
+ + VE +RE +L D L++ W D + +++ + + +
Sbjct: 8126 QEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSN 8185
Query: 4134 FIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAAC---------- 4183
L P ++ ++ +T +D + E D +L +L +A
Sbjct: 8186 LSLSLAQP------LRSERSGRDT-PASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEE 8238
Query: 4184 GEPDKPIVKKS--------IDELNSAWDSLNKAWKDRIDKLEEAMQAAV-QYQDGLQAVF 4234
G+ DK + I E A+ L + A+++ + Q L
Sbjct: 8239 GQDDKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSR 8298
Query: 4235 DWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTE 4294
+ + S +P G +L+T + +L E ++RL H+ + + +
Sbjct: 8299 FQIQQTENIIRSKTPTGPELDTSYKGYMKLL---GECSSSIDSVKRLEHKLKEEEESLPG 8355
Query: 4295 ESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLL 4354
+ H+ + + W+ L+ + ++++ +++ L QF L+ + AWL TE L
Sbjct: 8356 FVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEEL 8415
Query: 4355 SEQK--PVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQN 4412
+ + + D + IE+++ K LQ V ++ + ++N + ++ + +E+ +LQ+
Sbjct: 8416 EQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADS-KESRDLQD 8474
Query: 4413 KLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGL 4472
+L +N RW V E+ + L AL Q +GFH L L + +R P+
Sbjct: 8475 RLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDS- 8533
Query: 4473 PETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQML-------ARCPKSAETNIDQDINN 4525
N+ E+ ++ +K LMQ ++L + S + ++ + +
Sbjct: 8534 --------NLDAEIL------QDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTD 8579
Query: 4526 LKEKWESVETKLNERKTKLEEA------LNLAMEFHNSLQDFINWLTQAE 4569
E E V N K L+E L ++ +S QD +W + E
Sbjct: 8580 CLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQDLSSWSSADE 8629
Score = 264 bits (674), Expect = 2e-69
Identities = 859/4708 (18%), Positives = 1825/4708 (38%), Gaps = 698/4708 (14%)
Query: 621 LMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLEN 680
L+++ K L+S + L E E + +Q + WV +Q DR L ES L +
Sbjct: 2615 LLRMTKEKLRSCQVA--LQEHEALEEALQSMWFWVKAIQ---DR------LACAESTLGS 2663
Query: 681 HKNVHRAIEEFESSLKEAKISEIQMTAPL--------------KLTYAEKLHRLESQYAK 726
+ + + + + L E+++ + + +L L+ +A
Sbjct: 2664 KDTLEKRLSQIQDILLMKGEGEVKLNMAIGKGEQALRSSNKEGQRVIQTQLETLKEVWAD 2723
Query: 727 LLNTSRNQERHLDTL----HNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHA 782
++++S + + L+++ +++V R W+ E ++++ + + + K
Sbjct: 2724 IMSSSVHAQSTLESVISQWNDYVERKNQLEQWM-ESVDQKIEHPLQPQ-PGLKEKFVLLD 2781
Query: 783 ELMRELDQKEENIKSVQEIAEQL--LLENHPARLTIEAYRAAMQTQWSWILQLCQ----C 836
L L + E++ +++ + + L E + + ++TQ++ I+ + +
Sbjct: 2782 HLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQEELKTQFNDIMTVAKEKMRK 2841
Query: 837 VEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEE 896
VE+ +K++ Y + + E TD+L + K+ + R SS Q+ + + +E
Sbjct: 2842 VEEIVKDHLMYLDAVH---EFTDWLHSAKEELHRWSDMSGDSSA------TQKKLSKIKE 2892
Query: 897 LLQYKSTIANLMGKAKTIIQLKPRN---SDCPLKTSIPIKAICDYRQIEITIYKDDECVL 953
L+ + A+ + + +++ +N S C L + D++Q E ++++ C L
Sbjct: 2893 LIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQSC-L 2951
Query: 954 ANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINM 1013
N + +G A + ++A++ + + + + LTL + +
Sbjct: 2952 ENLVSQMALSEQEFSGQVAQL-----------EQALEQFSALLKTWAQQLTLLEGKNTDE 3000
Query: 1014 KSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSD 1073
+ V WH +D ++ + + +L+S+ + S++ +SG
Sbjct: 3001 EIVECWHKGQEILDALQKAEPRT-------------EDLKSQLNELCRFSRDLSTYSGK- 3046
Query: 1074 ITQLEKEVN-VCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRT 1132
++ L KE N +C Q S + +E+ + + R+ + L N + +
Sbjct: 3047 VSGLIKEYNCLCLQ------ASKGCQNKEQILQQRFRKAFRDFQQWLVNAKITTAKCFDI 3100
Query: 1133 PLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNV 1192
P ++ S+ +I E E E + L + +K E S +++++
Sbjct: 3101 PQNISEVSTSLQKIQE---FLSESENGQHKLNMMLSK-GELLSTLLTKEKAKGIQAKVTA 3156
Query: 1193 VLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLI 1252
++ +S L+ + + +K+ + + ++ + +K E+ V N + +L
Sbjct: 3157 AKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLSKT--EKMVHESSNRLYDLP 3214
Query: 1253 STLKQWRSEVDEKRQVFHALEDELQKAKAISDEMF------KTYKERDLDFDWH------ 1300
+ ++ + ++ + H E +L + K + +++ K+++ R
Sbjct: 3215 AKRRE-QQKLQSVLEEIHCYEPQLNRLKEKAQQLWEGQAASKSFRHRVSQLSSQYLALSN 3273
Query: 1301 --KEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTY-HPLDDW------------ 1345
KEK +L +R H Q +++L+ + D+Y HP D
Sbjct: 3274 LTKEKVSRL-DRIVAEHNQFSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEA 3332
Query: 1346 ---IQQVETTQRK---------IQENQPENSKTLATQLNQQK-----MLVSEIEMKQSKM 1388
++Q + Q K +Q PE T+ QL K +L + I K
Sbjct: 3333 LLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLE 3392
Query: 1389 DECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRR---RMQSSADLIIQEFMDLRT 1445
K+ Y V+ + + A ++ ++ + R M A L+ +E +
Sbjct: 3393 GALSKWTS-YQDGVRQFSGWMDSMEANLNESERQHAELRDKTTMLGKAKLLNEEVLS--- 3448
Query: 1446 RYTALVTLMTQYIKFAGDS--------LKRLEEEEKSLEEEKKEHVEKAKELQKWVSNIS 1497
Y++L L T +K AG + L+ L+E ++++E KE V K+++L +
Sbjct: 3449 -YSSL--LETIEVKGAGMTEHYVTQLELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQ 3505
Query: 1498 KTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQ 1557
+ LK E L + + + + GD T E ++
Sbjct: 3506 RDLKAFEV---------------------WLGQEQEKLDQYSVLEGDAHTHETTLRDLQE 3544
Query: 1558 VKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRL 1617
++ L + L ++ SG + E++ + +Q+++ + + TQ N
Sbjct: 3545 LQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSETRTQFNN-- 3602
Query: 1618 IGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFL--KENGEKLSQE 1675
++ + +K+Q E L+ AE K E ++ E++
Sbjct: 3603 -------VVNKLRLMEQKFQQVDEWLKT---------AEEKKWHEEVTAYRDEVEEVGAR 3646
Query: 1676 DKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIEN 1735
+ ++++ +++ C+ L + L + EE ++ LEES++ + +
Sbjct: 3647 AQEILDESHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEE-----IQSLEESESSLSS 3701
Query: 1736 LLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGT 1795
DW + K+ + TK +V +T + G+
Sbjct: 3702 YSDWYGSTHKNFKNVATKIDKV----------------------------DTVMMGKKLK 3733
Query: 1796 TQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQK----NM 1851
T E L + +K + +SA+ E+ +YL E E+L+K +M
Sbjct: 3734 TLEVLLKDMEKGHS--------------LLKSAREKGERAVKYLEEGEAERLRKEIHDHM 3779
Query: 1852 KELKVHYETALAES---EKKMKLTHSLQEE---LEKFDADYTEFEHWLQQSEQELENLEA 1905
++LK T E EK + L ++ L ++ A+Y E H ++ + EL +A
Sbjct: 3780 EQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKA 3839
Query: 1906 GADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRD------GGKV 1959
+L + KS + V+SH+ ++ + G +LE + + +D
Sbjct: 3840 ----------QLSKYKSLQQTVLSHEPSVKSVREKGEALLELVQDVTLKDKIDQLQSDYQ 3889
Query: 1960 DTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDK------YQHYE------DAS 2007
D + + + ++ DR +L K + L D + + H + A
Sbjct: 3890 DLCSIGKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAI 3949
Query: 2008 CGLLAGL-QACEATASKHLSEPIAVDP-----KNLQRQLE---ETKALQGQISSQQVAVE 2058
C + Q+ E KH+S + +Q LE + + + Q
Sbjct: 3950 CSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFR 4009
Query: 2059 KLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQD 2118
L++ A LD S+ N KT +K + + + ++ L ++ ++
Sbjct: 4010 ALQEQARTYLDLLCSMCDLSNASVKTT----------AKDIQQTEQTIEQKLVQAQNLTQ 4059
Query: 2119 GLDEMLDWMGNVESSLKEQGQV---------PLNSTALQDIISKNIMLEQDIAGRQSSIN 2169
G +E+ + L++ Q L Q+++S+ + + +Q+S+N
Sbjct: 4060 GWEEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQASVN 4119
Query: 2170 AMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLS 2229
+ EKV K + + S ++ L+ ++ + + + EE + + +
Sbjct: 4120 TIIEKVNKLTKKEE----SPEHKEINHLNDQWLDLCRQSNNLCLQREEDLQRTRDYHDCM 4175
Query: 2230 EKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFL----EHKKHLEVLHSLLKEIS 2285
++ FLE T TE D + E + E+ + E K +E L +++
Sbjct: 4176 NVVEVFLEKFT---TEWDNLARSDAESTAVHLEALKKLALALQERKYAIEDLKDQKQKMI 4232
Query: 2286 SHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKET 2345
H DK LV E+T++L +++ ++ED IK K + + E+L+ Q + L W +E
Sbjct: 4233 EHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQ 4292
Query: 2346 TKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKA 2405
QP+ AE L K S Q + +++C+ + A K+
Sbjct: 4293 -------QPNI-AEAL------------KQSPPPDMAQNLLMDHLAICSELEAKQMLLKS 4332
Query: 2406 IAAVKSGGAVLNGEGTATNTEEFWANKGLTS---IKKDMTDISHGYEDLGLLLKDKIAEL 2462
+ +K V+ A+ GL I+K ++D L L+ + L
Sbjct: 4333 L--IKDADRVM-------------ADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYL 4377
Query: 2463 NTKLS-KLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQ 2521
N LS K Q A Q Q K + P D V QV+ KS +A LK
Sbjct: 4378 NKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDD---VSKQVKTCKSAQASLKT 4434
Query: 2522 NVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNL 2581
N+V L + EL++E + E L E+ S + + Q R Q+LE++ +
Sbjct: 4435 YQNEVTGLWAQGRELMKEVTE-QEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSR 4493
Query: 2582 TQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTA 2641
F+ + WL + +++ L + + L+TQ + Q +L++ P+YE L
Sbjct: 4494 KHFKEDFDKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQ----SPEYENLLL 4549
Query: 2642 AGQGILSRPGED--PSLRGI----VKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQY 2695
L R G+ PSL + + E+L A+ ++++ + D+ + +AI+ +Y
Sbjct: 4550 T----LQRTGQTILPSLNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEY 4605
Query: 2696 QSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCE 2755
SL+ + LS+L+ + V T + +E A ++ + ++ +
Sbjct: 4606 ASLIELTTQSLSELEAQFLRMSKVPT-----DLAVEEALSLQDGCRAILDEVAGLGEAVD 4660
Query: 2756 DLSALVKEEYLKAELSRQLEGIL---KSFKDVEQKAENHVQHLQSACASSHQFQQMSRDF 2812
+L+ KE + Q + +L + ++++ E V L+ ++ + ++M +
Sbjct: 4661 ELNQ-KKEGFRSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQL 4719
Query: 2813 QAWLDTKKEEQNKSH----PISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLL 2868
+ L + KEEQ+K + P KL + SL +D L + E
Sbjct: 4720 ERQLKSVKEEQSKVNEETLPAEEKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPH----- 4774
Query: 2869 LKTQGSEKAALQLQ--LNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWID 2926
L EKA Q+Q +K + V E E+++ +S++ ++ ++ W+
Sbjct: 4775 LDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQSID----FQTEMSRSLDWLR 4830
Query: 2927 KCQNNLE-EIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEV 2985
+ + L + L+ + + I K++ Q+E+ ++ L++ + KE+
Sbjct: 4831 RVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKA---KEL 4887
Query: 2986 VT-DENKSLIQKVDM---VTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDI 3041
++ D SL + ++ + E L +++ L + + + + +V + + L+ A+E L +
Sbjct: 4888 ISADLEHSLAELSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQL 4947
Query: 3042 H----DSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLL 3097
D ++ ++ T+ + L+ L L D +++ + G D+
Sbjct: 4948 AGNGLDVESAEENLKSHMEFFSTEDQFHSNLEELHSLVATL--DPLIKPT---GKEDLEQ 5002
Query: 3098 QVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRD 3157
+V ++ +S+ + L+ +Q E+ + + +L + +
Sbjct: 5003 KVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTS 5062
Query: 3158 A-----ETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDL--VGIKRDLE 3210
+ E L + K + E ++A + A++ E+T D + R +
Sbjct: 5063 SSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQ-------LEKTGNDASKATLSRSMT 5115
Query: 3211 ALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEH---EESQGPVGME 3267
+ ++ +L AQ +E+ +E + F +K+K+ + ++ + ++ ++ E
Sbjct: 5116 TVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAE 5175
Query: 3268 TETINQQLNMFKVFQKEEIEPLQG--KQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNA 3325
T+ + + F V + E+ + G +QQ ++ L G +A L ++ +
Sbjct: 5176 LLTLLEYHDTF-VLELEQQQSALGMLRQQTLSMLQDG---AAPTPGEEPPLMQEITAMQD 5231
Query: 3326 RWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQ 3385
R + +KV +++ L + + S+ W+ +T+E + N P+ E + AQ
Sbjct: 5232 RCLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQETKEYLGN---PTIE---IDAQ 5285
Query: 3386 IQE-QKLLQRLLDDRKSTVEVIKREGEKI--ATTAEPADKVKILKQLSLLDSRWEALLNK 3442
++E Q LL + R++ ++ + + EK T P++ L +++ LD + + ++
Sbjct: 5286 LEELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILPSELSLQLAEVA-LDLK---IRDQ 5341
Query: 3443 AETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALE 3502
+ + +++E +Q+ ++ L + LTTI +L + + + K L
Sbjct: 5342 IQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKL------KAKTDNVVQAKTDQKVLG 5395
Query: 3503 DDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQA 3562
+++ N L + + Q + + K + + +++ I++ + +R L QA
Sbjct: 5396 EELDGCNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQ-AENRLSKLNQA 5454
Query: 3563 LCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELR---VLQEDILLRKQ 3619
+ + + E ++ W + K V + T W S+LR +L + +L +
Sbjct: 5455 ASHLEEYNEMLELILKW-------IEKAKVLAHGTIA-WNSASQLREQYILHQTLLEESK 5506
Query: 3620 NVDQALLNGLELLKQTT--------GDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQA 3671
+D L E L+ T +V + + E ++ K + D AK +++
Sbjct: 5507 EIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKF 5566
Query: 3672 LQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLD 3731
++L + E+ L EV LS + Q+ + L E ++ K +
Sbjct: 5567 EAELKKLQAALEQAQATLTSPEVGRLSLKEQL----------SHRQHLLSEMESLKPKVQ 5616
Query: 3732 SLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAA 3791
++ SAL A L E + T Q+ + AA+++ +Q++Q
Sbjct: 5617 AVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEM 5676
Query: 3792 DAELSWITETEKKLMSL--GDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKI 3849
K L L G R +D+ A +Q+ +I RH+++ + +I
Sbjct: 5677 -----------KHLQQLIEGAHREIEDKPVATSNIQE-LQAQISRHEELAQKIKGYQEQI 5724
Query: 3850 MTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTE 3909
+ S+ + +MK K ++ L + + L + EL P +
Sbjct: 5725 ASLNSKCKMLTMKAK--------------HATMLLTVTEVEGLAEGTEDLDGELLPTPSA 5770
Query: 3910 TQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSI 3969
S++ H L P ++ + G SP +
Sbjct: 5771 HPSVVMMTAGRC------------HTLL-------SPVTEESGEEGTNSEISSPP---AC 5808
Query: 3970 QEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSIS 4029
+ A+T S ++ +A++ + + + + H E E +E PS +
Sbjct: 5809 RSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLE-----PSAT 5863
Query: 4030 AEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQM 4089
A++ ++ KNV EK + LYE L+++ + QD L
Sbjct: 5864 AKLGDLQRSWETLKNVI--SEKQRTLYEALERQ-----------------QKYQDSL--- 5901
Query: 4090 VFIWENIHTLVEEREAKLLDVME---LAEKFWCDHMSLIVTIKDTQDFIRDL-------- 4138
++I T +E E KL + E E +H +L+ I QD I +L
Sbjct: 5902 ----QSISTKMEAIELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEEL 5957
Query: 4139 --EDPGIDP-------SVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKP 4189
E DP S + E TIR + G ++ L+ +N +L E
Sbjct: 5958 VSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLN--DQLEEQRQEQALQ 6015
Query: 4190 IVKKSIDELNSAWDSLNKAWKD-RIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMS 4248
+ DEL+S W KA D + +E M Q D + + K+ ++S
Sbjct: 6016 RYRCEADELDS-WLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVE----IEQKVVALS 6070
Query: 4249 PIGTDLETV--------KQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHT 4300
+ E + K + E+L +E++R H +L ++ +E ++
Sbjct: 6071 ELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQEKEESD 6130
Query: 4301 ----------VQDPLMELKLIWDSLEERIINRQHKLEGAL----------LALGQ---FQ 4337
VQ+ L + + W + + +Q +LE L + G+ Q
Sbjct: 6131 VDLTATQSPGVQEWLAQARTTWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQ 6190
Query: 4338 HALDELLAWLTHTEGLLSEQKPVGGDPKAIEIEL------------AKHHVLQNDVLAHQ 4385
H+ E +LS++ + G+ + E ++ K +LQN + Q
Sbjct: 6191 HSAAETSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQKLLQN--VLEQ 6248
Query: 4386 STVEAVNKAGNDLIE-------SSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGA 4438
+ + N L+ ++ S + + L+ LNQ ++ V ++ K+Q +
Sbjct: 6249 EQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQ---S 6305
Query: 4439 LRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYK 4498
+ + + + WL D E L + L LPE + L + E+ A + KE + +
Sbjct: 6306 IHLEQKLYDGVSATSTWLDDVEERLFVATAL--LPEETETCL-FNQEILAK-DIKEMSEE 6361
Query: 4499 SLMQKGQQMLARC-PKSAETN--IDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFH 4555
M K + + ++ P++ + I+ + L + +++ +N+R +++E L + F
Sbjct: 6362 --MDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQ 6419
Query: 4556 NSLQDFINWLTQ-----AEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELD 4610
N L+ L ++ NV +P V QI+ + + + IIEL
Sbjct: 6420 NDLKVLFTSLADNKYIILQKLANVFEQP------VAEQIEAIQQAEDGLKEFDAGIIELK 6473
Query: 4611 KTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKL 4670
+ G L+ L +Q +++++ + R L+ Q+ A L
Sbjct: 6474 RRGDKLQVEQPSMQE------LSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDL 6527
Query: 4671 MEWLEE-SEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKT 4729
+ LE EK + I + ++I+ L +HKE+ + L + + +T R S +
Sbjct: 6528 ADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQ- 6586
Query: 4730 SLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEP 4789
K +EL + + ++ +R +LE L + Q L L VE
Sbjct: 6587 -------KETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVES 6639
Query: 4790 QLAEDQPVHGDIDLVMNLIDNHKAFQKELGK-RTSSVQALKRSARELIEGSRDDSSWVKV 4848
+ V + D +++ I ++ + L + + Q L R LI S D ++
Sbjct: 6640 SIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSD---LES 6696
Query: 4849 QMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRF----HGV 4904
Q+ +L W + + RLE L+ + S L+ WL A+ L F
Sbjct: 6697 QLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVT 6756
Query: 4905 LPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRA 4964
+P + + +R ++ EF K+++ + + + + G+ +L + D+ T++ ++ I +
Sbjct: 6757 VPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDT-ATLRSELSRIDS 6815
Query: 4965 RFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEI--EE 5022
++ ++L Q++L + + + +++W+ E + KD++ I I +
Sbjct: 6816 QWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVI-QKDEDNIKNSIGYKA 6874
Query: 5023 VKALIAEHQTFMEEMTRKQPDVDKVTKT 5050
+ + +++ F ++ KQ VD V ++
Sbjct: 6875 IHEYLQKYKGFKIDINCKQLTVDFVNQS 6902
Score = 244 bits (624), Expect = 1e-63
Identities = 745/4103 (18%), Positives = 1582/4103 (38%), Gaps = 573/4103 (13%)
Query: 1074 ITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTP 1133
+T LE E+NV + +QEL++ AE ++ I+E + ++ L+ +
Sbjct: 4269 VTNLE-ELNVVQSRFQELMEWAEEQQPN-------IAEALKQSPPPDMAQNLLMDHLAIC 4320
Query: 1134 LERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVV 1193
E + + + L K+ +R+ DLG E Q A S + +S +N
Sbjct: 4321 SELEAKQMLL------KSLIKDADRVMADLGLN----ERQVIQKALSDA----QSHVNC- 4365
Query: 1194 LQNMNQVYSMSSTYIDK-LKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLI 1252
++ + Y++K L L A + ++ +E K+ E + +++ +
Sbjct: 4366 ---LSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQV 4422
Query: 1253 STLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQ 1312
T K ++ + ++E+ A E+ K E++ K + Q V +
Sbjct: 4423 KTCKSAQASLK-------TYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSV--YD 4473
Query: 1313 NVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLN 1372
+V + +RL++LE S K++++ + W++Q + + N S L TQL
Sbjct: 4474 SVLQKCSHRLQELEKNLVSRKHFKEDFDKACHWLKQADIVTFP-EINLMNESSELHTQLA 4532
Query: 1373 QQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSS 1432
+ + ++ + ++ + Q+ + ++ + + ++ + +Q + + +
Sbjct: 4533 KYQNILEQSPEYENLLLTLQRTGQTILPSLNEVDHSYLSEKLNALPRQFNVIVA--LAKD 4590
Query: 1433 ADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLE--------EEEKSLEEEKKEHVE 1484
+QE + R Y +L+ L TQ + R+ EE SL++ + ++
Sbjct: 4591 KFYKVQEAILARKEYASLIELTTQSLSELEAQFLRMSKVPTDLAVEEALSLQDGCRAILD 4650
Query: 1485 KAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGD 1544
+ L + V +++ + G+P Q + L + L+ H
Sbjct: 4651 EVAGLGEAVDELNQKKEGFRSTGQP----------------WQPDKMLHLVTLY---HRL 4691
Query: 1545 KMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQ 1604
K E+R L + + + + + + +QL+ + EE + AE + + L
Sbjct: 4692 KRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNEETLPAEEKLKMYHSLA 4751
Query: 1605 GICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENF 1664
G R+ H E + +K + + + Q +++ A+ E V E+
Sbjct: 4752 GSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESR 4811
Query: 1665 LKENGEKLSQEDKAL---------------IEQKLNEAKIKCEQLNLKAEQSKKELDKVV 1709
+ ++ + ++ ++L ++ L + + + ++ + E+ + L +++
Sbjct: 4812 MVQSIDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSL-RIM 4870
Query: 1710 TTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHK----QVIEQNGTHF 1765
+E EK K+L + +E+ L LS +D D + A + ++ Q ++
Sbjct: 4871 NALSHKEKEKFTKAKELISAD--LEHSLAELSELDGDIQEALRTRQATLTEIYSQCQRYY 4928
Query: 1766 QEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIAT 1825
Q + E+ + L +D V + +ENL H + S
Sbjct: 4929 QVFQAANDWLEDAQELLQLAGNGLD--VESAEENLKS--------HMEFFSTEDQFHSNL 4978
Query: 1826 QSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDAD 1885
+ L+ + P KE L++ + L++ + +S ++ L + +
Sbjct: 4979 EELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQKA 5038
Query: 1886 YTEFEHWLQQSEQELENLEA-GADDINGLMTKLKRQK-------SFSEDVISHKGDLRYI 1937
E + +E++L + KL K SF E +++ + +
Sbjct: 5039 REEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQL 5098
Query: 1938 TISGNRVLEAAKSCSKRDGGKVDTS--ATHREVQRKLDHATDRFRSLYSKCNVLGNNLKD 1995
+GN +A S S + T A ++ ++ L+ A D + +K +
Sbjct: 5099 EKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMIDQ 5158
Query: 1996 LVDKYQ----------------HYEDASCGLLAGLQAC---------------------- 2017
L DK Y D L Q+
Sbjct: 5159 LQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGE 5218
Query: 2018 ------EATASK----HLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKK---TA 2064
E TA + ++ E + + K ++++L++ + ++ QI+S + V++ K+
Sbjct: 5219 EPPLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQETKEYLGNP 5278
Query: 2065 EVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEK---LQITLTRSLSVQDGLD 2121
+ +DA+ ++Q L + +++ K E+ EK L L LS+Q L
Sbjct: 5279 TIEIDAQ------LEELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILPSELSLQ--LA 5330
Query: 2122 EM---LDWMGNVESSLKEQGQVPLNSTALQDIISK-----------------NIM----- 2156
E+ L ++ +KE Q S L I K N++
Sbjct: 5331 EVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTD 5390
Query: 2157 ---LEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLA 2213
L +++ G S + ++ V+KF+E L K+ L+ + + + L+
Sbjct: 5391 QKVLGEELDGCNSKLMELDAAVQKFLEQNG-QLGKPLAKKIGKLTELHQQTIRQAENRLS 5449
Query: 2214 KMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTEL-SQYMQEST--SEFLEH 2270
K+ + + +E + + E + ++E K + L + ++L QY+ T E E
Sbjct: 5450 KLNQAASHLEEYNEMLELILKWIE-KAKVLAHGTIAWNSASQLREQYILHQTLLEESKEI 5508
Query: 2271 KKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDA 2330
LE + L+ ++S + ++ L ++ +E+ IK + + + + +
Sbjct: 5509 DSELEAMTEKLQYLTSVYCTEKMS---QQVAELGRETEELRQMIKIRLQNLQDAAKDMKK 5565
Query: 2331 FQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGI 2390
F+ +K L++ +++ + + P G L + L + L + P++Q V
Sbjct: 5566 FEAELKKLQAALEQA--QATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQ---- 5619
Query: 2391 SLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKG--LTSIKKDMTDISHGY 2448
LC SA+ P +A++ A L + A+ + + + +
Sbjct: 5620 -LCQ--SALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEM 5676
Query: 2449 EDLGLLLKDKIAELNTK---LSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAV 2505
+ L L++ E+ K S +Q+ Q + S + QK+ +Q+ A ++
Sbjct: 5677 KHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKG----YQEQIASLNS--- 5729
Query: 2506 KTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQ 2565
K ++ K+ A + V +V+ L + +L E TP A M+T + L
Sbjct: 5730 KCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTA--GRCHTL-- 5785
Query: 2566 LTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQIL 2625
L+ ++ EE +N+ + P++ +N Q L
Sbjct: 5786 LSPVTEESGEEGTNSE--------------ISSPPACRSPSPVANTDASVNQDIAYYQAL 5831
Query: 2626 LQE-FATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDW 2684
E T + T+A Q PG +PS +L + + W++L +S++
Sbjct: 5832 SAERLQTDAAKIHPSTSASQEFYE-PGLEPSATA----KLGDLQRSWETLKNVISEKQRT 5886
Query: 2685 IDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEK 2744
+ +A+ + +YQ L+S+S K+ ++ KLS S P++ Q+ Q + EI +
Sbjct: 5887 LYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPES---QMAEHQALMDEILMLQ 5943
Query: 2745 KQIKVAQ-ALCEDLSALVKEEYLKAELSRQ--LEGILKSFKDVEQKAENHVQHLQSACAS 2801
+I Q +L E+L + E +L+ Q L + + + KA Q L+
Sbjct: 5944 DEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLND 6003
Query: 2802 SHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMY---- 2857
+ Q+ + Q + E + A LD S K+ D L +M
Sbjct: 6004 QLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIE 6063
Query: 2858 EKTIA------EGENLLLKTQGSEK-----------------AALQLQLNTIKTNWDTFN 2894
+K +A ENLLL+ + K LQ L+ + N
Sbjct: 6064 QKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTA 6123
Query: 2895 KQVKERENKLKESLEKAL-KYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKS 2953
++ +E + L + + ++ Q T W + Q++L++ K E E +A+ KS
Sbjct: 6124 QEKEESDVDLTATQSPGVQEWLAQART--TWTQQRQSSLQQQK------ELEQELAEQKS 6175
Query: 2954 LQKE---------------------------MDQHFGMV--------------ELLN--- 2969
L + + Q GM E L+
Sbjct: 6176 LLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESLHQEF 6235
Query: 2970 NTANSLL-SVCEIDKEVV--TDENKSL----IQKVDMVTEQLHSKKFCLENMTQKFKEFQ 3022
+T LL +V E ++E V + N+ L + K D+ T+ + L+ + Q F+E
Sbjct: 6236 STKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVS 6295
Query: 3023 EVSKESKRQLQCAKEQL------------DIHDSL--GSQAYSNKYLTMLQTQQ---KSL 3065
S +KRQ +++L D+ + L + + T L Q+ K +
Sbjct: 6296 SQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDI 6355
Query: 3066 QALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQ 3125
+ + ++D K L E D++ + L + S L V+++C ++ +LQ
Sbjct: 6356 KEMSEEMDKNKNLFSQAFPENGDNRDVIEDTL--GCLLGRLSLLDSVVNQRCHQMKERLQ 6413
Query: 3126 GIGHFQNTIREMFSQFAEFDDE---LDSMA-----PVGRDAETLQKQKETIKAF------ 3171
I +FQN ++ +F+ A D++ L +A PV E +Q+ ++ +K F
Sbjct: 6414 QILNFQNDLKVLFTSLA--DNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIE 6471
Query: 3172 -LKKLEALMASNDNANKTCKMMLATEETSPDL----VGIKRDLEALSKQCNKLLDRAQAR 3226
++ + L + + K+ +E + G+ ++L S+ L D A
Sbjct: 6472 LKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLL 6531
Query: 3227 EEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEI 3286
E E + S +E LL K +E+ + + TET+ +++ F V
Sbjct: 6532 ETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAV------ 6585
Query: 3287 EPLQGKQQDVNWLGQGLIQSAA--KSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEA 3344
Q++ + + + Q++A K +G+E L+ + W L++ + + QL
Sbjct: 6586 ------QKETQFHTELMAQASAVLKRAHKRGVE--LEYILETWSHLDEDQQELSRQL--- 6634
Query: 3345 LLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQE-QKLLQRLLDDRKSTV 3403
+ +ES + + EE ++ +K+ + E Q L ++LDD
Sbjct: 6635 --------EVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDD----- 6681
Query: 3404 EVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHET 3463
G+++ + +D + QL+ L W + NK +LE I ++
Sbjct: 6682 ------GKRLLISISCSD---LESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSE 6732
Query: 3464 LEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLK 3523
L WL + + RL TQ S + Q + D +N + V SLK
Sbjct: 6733 SADLIHWLQSAKDRL----EFWTQQS---VTVPQELEMVRDHLNAFLEFSKEVDAQSSLK 6785
Query: 3524 --VLSS--------REDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDE 3573
VLS+ + D ++S+L + ++ + E L Q +
Sbjct: 6786 SSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAI 6845
Query: 3574 VELMNWLNEVHDKLSKLSVQDYSTEG---LWKQQSELRVLQEDILLRKQNVDQALLNGLE 3630
E+M+W++ + + + K ++ G + + + + + DI ++ VD + L+
Sbjct: 6846 SEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQ 6905
Query: 3631 LLKQ---TTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCT 3687
+ Q + + ++L A+ ++ + L T+ + LE L+ + + L T
Sbjct: 6906 ISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKT 6965
Query: 3688 WLDKVEVELLSYETQVLKGEEAS-------------QAQMRPKELKKEAKNNKALLDSLN 3734
W + E L + Q G++AS + + KE++K +N AL+ +
Sbjct: 6966 WFETQEKRL---KQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKK 7022
Query: 3735 E-----VSSALLELVPWRAR--------EGLEKMVAEDNERYRLVSDTITQKVEEIDAAI 3781
E V S L EL A + L K V + +++ D I + E ++
Sbjct: 7023 EDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSL 7082
Query: 3782 LRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDD 3841
R + + +A + L +L D LE+ + S Q + I +
Sbjct: 7083 SRFRLLTGSLEA----VQVQVDNLQNLQD-DLEKQERSLQ------------KFGSITNQ 7125
Query: 3842 LVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYE 3901
L+K H +T +++ L +V ++ + + +E QL+ +++L+ Q W+ Y+
Sbjct: 7126 LLKECHPPVT-------ETLTNTLKEVNMRWNNLLEEIAE---QLQSSKALL-QLWQRYK 7174
Query: 3902 ELWPWLTETQSIISQLPAPALEYETLRQQQEEH--------RQLRELIAEHKPHIDKMNK 3953
+ T L+ T + ++ L + + K + +++
Sbjct: 7175 DYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHE 7234
Query: 3954 TGPQL-LELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQIL 4012
G QL ++ +IQ ++ +++ + K+ +L + F ++ +
Sbjct: 7235 LGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALE 7294
Query: 4013 ESLERIVERLR-QPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSG 4071
+ E L+ Q PS S+++ I+E++ E K + + P + L + G +
Sbjct: 7295 AWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLPL--- 7351
Query: 4072 GTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDT 4131
DK+I ++ + W I + ER +KL + F H + + +
Sbjct: 7352 -NDKEIK------RMQNLNRHWSLISSQTTERFSKL-------QSFLLQHQTFLEKCETW 7397
Query: 4132 QDFIRDLEDP-GIDPS----VVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEP 4186
+F+ E ++ S + +QQ A E + E+ Q+ L +I G L+
Sbjct: 7398 MEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVD 7457
Query: 4187 DKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDW-VDIAGGKLA 4245
D+ + L++ W + + + R ++ ++ +Y++ + + W V+++ ++
Sbjct: 7458 DRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMS 7517
Query: 4246 SMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPL 4305
+ + L+ + +E+ QFK + + +Q L +A L + + +Q L
Sbjct: 7518 GLGSVPIPLQQARTLFDEV-QFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAEL 7576
Query: 4306 MELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPK 4365
E++ W S R+ ++ KL L + + + + L L + LS+ P +
Sbjct: 7577 AEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLP--DHHE 7634
Query: 4366 AIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVL 4425
+ E + L+N V + + ++ + L + ++ S L ++E+L ++W+ +
Sbjct: 7635 ELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELC 7694
Query: 4426 EKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHME 4485
+ R+QQ+ L + F + ++L +WLT E + + + K + + E
Sbjct: 7695 HQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLKKDYQEE 7754
Query: 4486 VCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLE 4545
+ A E K + L Q G+++ +S + I+ + + ++W+ + + R KL+
Sbjct: 7755 IAIAQENKIQ----LQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLK 7810
Query: 4546 EALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQ 4605
E L + ++ WL E L ++P +++ + ++N +E
Sbjct: 7811 ETLVAVQQLDKNMSSLRTWLAHIESEL---AKP------IVYDSCNSEEIQRKLNEQQEL 7861
Query: 4606 IIELDKTGTHLKYFSQKQDVVL--------------IKNLLISVQSRWEKVVQRLVERGR 4651
+++K T + +V+L I+ ++ RW + +ER
Sbjct: 7862 QRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRL 7921
Query: 4652 SLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAK 4711
+++ + ++F + +S+ +WL+ SE++ K +L + + FQ+ +
Sbjct: 7922 KIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHEC 7981
Query: 4712 HSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSG 4771
+ + N+ R L + + D L M+ E +WD + + +L+ +
Sbjct: 7982 LTQLELINKQYRRL-ARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQRE 8040
Query: 4772 QFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRS 4831
+F A +++ WL ++ QL + H V I KAFQ+E+ + ++ +
Sbjct: 8041 EFETARDSILVWLTEMDLQLTNIE--HFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQ 8098
Query: 4832 ARELIEGSRD-DSSWVKVQMQEL 4853
+LIE S D++ ++ ++ EL
Sbjct: 8099 GEQLIEKSEPLDAAIIEEELDEL 8121
Score = 243 bits (621), Expect = 3e-63
Identities = 877/4762 (18%), Positives = 1749/4762 (36%), Gaps = 848/4762 (17%)
Query: 631 SSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSD-LPSVE---SHLENHKNVHR 686
S L++N+ +++ D+L+ DE++ W ++ +P + S+L+NH
Sbjct: 2189 SEKLEENMDRLRVSLSIWDDVLSTRDEIE------GWSNNCVPQMAENISNLDNHLRAEE 2242
Query: 687 AIEEFESSLKE---------AKISEIQ-----MTAPLKLTYAEKLHRLESQYAKLLNTSR 732
++EFES +K +K+++++ + P L + E + ++AK +
Sbjct: 2243 LLKEFESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEIT--- 2299
Query: 733 NQERHLDTLHNFVSRATNELIWLNE-----KEEEEVAYDWSERNTNIARKKDYHAELMRE 787
E TL +F +++T ++N+ + EE + ++ T A KK ++ +E
Sbjct: 2300 --EVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCAQNETCEALKKV--KDIQKE 2355
Query: 788 LDQKEENIKSVQEIAEQLLLENHPARL---------TIEAYRAAMQTQWSWILQLCQCVE 838
L ++ NI S QE L + H A L I+ + A Q L + +E
Sbjct: 2356 LQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLE 2415
Query: 839 QHIKENTAYF-EFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEEL 897
+H E+ F E+F AK A K S DR+ LE + + + +
Sbjct: 2416 KHFSESMQEFQEWFLGAKAAA------------KESSDRTGDSKVLEAKLHDLQNILDSV 2463
Query: 898 LQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNS 957
+S + + + +T+ + +I ++ AN
Sbjct: 2464 SDGQSKLDAVTQEGQTLYA---------------------HLSKQIVSSIQEQITKANEE 2502
Query: 958 HRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLW-HESHINMKSV 1016
+A K C ++ E Q++ L LW HE
Sbjct: 2503 FQAFLK-------------QCLKDKQALQDCASELGSFEDQHRK-LNLWIHEME------ 2542
Query: 1017 VSWHYLINEIDRIRASNVASIKTMLPGEHQQV------LSNLQSRFEDFLEDSQESQVFS 1070
+R N+ K +P + +V L L + E + SQ Q+ S
Sbjct: 2543 ----------ERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLS 2592
Query: 1071 GSDITQLEKEVNVCKQY---YQELLKSAEREEQEESV----YNLYISEVRNIRLRLENCE 1123
+ +E +C Q +Q LL+ + + + V + ++++ ++ +
Sbjct: 2593 -EEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAIQ 2651
Query: 1124 DRLIRQIRTPLERDDLHESVFRITEQEKLKKELE-RLKDDLGTITNKCEEFFSQAAASSS 1182
DRL T +D L + + +I + +K E E +L +G + A SS
Sbjct: 2652 DRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAIGK---------GEQALRSS 2702
Query: 1183 VPTLRSELNVVLQNMNQVYS-MSSTYIDKLKTVNLVLKN----TQAAEALVKLYETKLCE 1237
+ + L+ + +V++ + S+ + T+ V+ + L + E+ +
Sbjct: 2703 NKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQK 2762
Query: 1238 EEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAI----SDEMFKTYKER 1293
E + + ++ L +S + E AL + K++ + DE FK +
Sbjct: 2763 IEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQ- 2821
Query: 1294 DLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQ 1353
++L ++ ++ ++R +E I K Y D H DW+ +
Sbjct: 2822 -----------EELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEEL 2870
Query: 1354 RKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQ--YSATVKDYELQTMT 1411
+ + ++S T +L++ K L+ E+ S++ + A + + T EL
Sbjct: 2871 HRWSDMSGDSSAT-QKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTE 2929
Query: 1412 YRAM-------VDSQQKSPVKRRRMQSSADLIIQEFM-------DLRTRYTALVTLMTQY 1457
+A+ DS ++ + S L QEF +++AL+ Q
Sbjct: 2930 MQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQ 2989
Query: 1458 IKFAG-------------------DSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISK 1498
+ D+L++ E + L+ + E +++L + +S
Sbjct: 2990 LTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSG 3049
Query: 1499 TLKDAE----KAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGD--KMTDEERN 1552
+K+ +A K +K++I + + L ++ AK D + E
Sbjct: 3050 LIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVST 3109
Query: 1553 ELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQ 1612
L+K + L ES N +L + G++ KEK +GI +T
Sbjct: 3110 SLQKIQEFLSESEN-----GQHKLNMMLSKGELL--------STLLTKEKAKGIQAKVTA 3156
Query: 1613 TENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKL 1672
+ + +E K Q KD + SA+ + + + TE + E+ +L
Sbjct: 3157 AKEDWKNFHSNLHQKESALENLKIQ------MKDFEVSAEPIQDWLSKTEKMVHESSNRL 3210
Query: 1673 -----SQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLE 1727
+ ++ ++ L E QLN E++ ++ E AA K
Sbjct: 3211 YDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKA------------QQLWEGQAASKSFR 3258
Query: 1728 ESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLET 1787
+++ + LSN+ K E+ + V E N F G + D ++
Sbjct: 3259 HRVSQLSSQYLALSNLTK--EKVSRLDRIVAEHN--QFSLGIKELQDWMTDAIH------ 3308
Query: 1788 DVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAV---IIATQSAQVLLEKQGQYLSPEEK 1844
+D T + + +K + + Q + + +I T+ VL Q SPE
Sbjct: 3309 MLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVL-----QNTSPEGI 3363
Query: 1845 EKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLE 1904
+Q+ ++ +K + + L+ + + + +F W+ E L E
Sbjct: 3364 PTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESE 3423
Query: 1905 AGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSAT 1964
++ T L + K +E+V+S+ L I + G + E
Sbjct: 3424 RQHAELRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTE------------------ 3465
Query: 1965 HREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKH 2024
H Q +L +R+R++ + + LV +Q Y+ L+A E +
Sbjct: 3466 HYVTQLELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQ-------RDLKAFEVWLGQE 3518
Query: 2025 LSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKT 2084
Q +L++ L+G + + + L++ + + L N + T
Sbjct: 3519 ------------QEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQALL----NSVLHT 3562
Query: 2085 LDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNS 2144
+D++ + + ++ +L + DW Q ++
Sbjct: 3563 REDVI------PSGIPQAEDRALESLRQ------------DWQA-------YQHRLSETR 3597
Query: 2145 TALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSE- 2203
T ++++K ++EQ ++E +K E ++ + +++++ AR E
Sbjct: 3598 TQFNNVVNKLRLMEQ-------KFQQVDEWLKTAEEKKWHEEVTAYRDEVEEVGARAQEI 3650
Query: 2204 --ASHKHKETLAKMEELKTK--------VELFENLSEKLQTFLETKTQALTEVDVPG--- 2250
SH + + +L ++ +E + L E++Q+ E+++ + D G
Sbjct: 3651 LDESHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTH 3710
Query: 2251 KDVTELSQYMQESTSEFLEHK-KHLEVL-------HSLLKEISSHGLPSDKALVLEKTNN 2302
K+ ++ + + + + K K LEVL HSLLK G + K L +
Sbjct: 3711 KNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGEAER 3770
Query: 2303 LSK-------KFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPI-VQP 2354
L K + KE+ T++++ + F K+L WI E + + + +P
Sbjct: 3771 LRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEP 3830
Query: 2355 SFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGA 2414
+ L K LQ+ P ++ V G +L L+ VT K I ++S
Sbjct: 3831 KMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLELVQDVTLKDK-IDQLQSDYQ 3889
Query: 2415 VLNGEGTATNTEEFWANKGLTSIK-KDMTDISHGYEDLGLLLKDKI-------------- 2459
L G A E L +++ K T I + L LK +
Sbjct: 3890 DLCSIGKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAI 3949
Query: 2460 --------AELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQ 2511
L +L K Q+ WL +A + P+P + ++Q
Sbjct: 3950 CSTAQRMYQSLEHELQKHVSRQDTLQQCQAWL-----SAVQPDLEPSPQPPLSRAEAIKQ 4004
Query: 2512 NKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSK----------WQ 2561
K F A L++ +L + +L + T A +Q I+ K W+
Sbjct: 4005 VKHFRA-LQEQARTYLDLLCSMCDLSNASVKT-TAKDIQQTEQTIEQKLVQAQNLTQGWE 4062
Query: 2562 ELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQ 2621
E+ L + L+++ L + ++L+ L+I NM++ +
Sbjct: 4063 EIKHLKSELWIYLQDADQQLQNMKRRHSELE---------------LNIAQNMVSQVKDF 4107
Query: 2622 VQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDR 2681
V+ L + A+ E++ L++ E P +++ + +W L Q ++
Sbjct: 4108 VKKLQSKQASVNTIIEKVNK-----LTKKEESPE-----HKEINHLNDQWLDLCRQSNNL 4157
Query: 2682 CDWIDQAIVKSTQYQSLLRSLS---DKLSDLDNKLSSSLAVST--HPDAMNQQLETAQKM 2736
C ++ + ++ Y + + +K + + L+ S A ST H +A+ + Q+
Sbjct: 4158 CLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQER 4217
Query: 2737 KQEIQQEKKQ-IKVAQALCEDLSALVKEEYLKAELS-RQLEGILKSFKDVEQKAENHVQH 2794
K I+ K Q K+ + L D LVKE+ E QLE ++K +K + V +
Sbjct: 4218 KYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIK------RKIQVSVTN 4271
Query: 2795 LQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQS 2854
L+ +FQ++ W + ++ ++ S D+ ++L+ DH L A+
Sbjct: 4272 LEELNVVQSRFQEL----MEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICSELEAKQ 4327
Query: 2855 HMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKY 2914
+ + I + + ++ +E+ +Q L+ +++ + + V +R ++ L KAL
Sbjct: 4328 MLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQR----RKYLNKALSE 4383
Query: 2915 KEQ-VETLWPWIDKCQNNLEEIKF----CLDPAEGENSIAKLKSLQKEMDQHFGMVELLN 2969
K Q + ++ + Q + +I F CL P + + KS Q + + V L
Sbjct: 4384 KTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQNEVTGLW 4443
Query: 2970 NTANSLL-SVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKES 3028
L+ V E +K V + + L D V ++ + LE K F+E ++
Sbjct: 4444 AQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKEDFDKA 4503
Query: 3029 KRQLQCA-----------KEQLDIHDSLG--------SQAYSNKYLTMLQTQQ------- 3062
L+ A E ++H L S Y N LT+ +T Q
Sbjct: 4504 CHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQTILPSLN 4563
Query: 3063 --------KSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVD 3114
+ L AL Q ++ LA+D + ++ +L + +E+++L +
Sbjct: 4564 EVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEA-----ILAR-----KEYASLIELTT 4613
Query: 3115 EKCSFLETKLQGIGHFQN--TIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFL 3172
+ S LE + + + E S LD +A +G + L ++KE +
Sbjct: 4614 QSLSELEAQFLRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVDELNQKKEGFR--- 4670
Query: 3173 KKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEG 3232
S + KM+ LV + L+ ++Q LL+ + ++ E
Sbjct: 4671 --------STGQPWQPDKML--------HLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEK 4714
Query: 3233 TIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGK 3292
++LE +K E Q V ET ++L M+ L G
Sbjct: 4715 MCQQLERQLKSVK-------------EEQSKVNEETLPAEEKLKMY--------HSLAGS 4753
Query: 3293 QQDVNWLGQGL---IQSAAKSTSTQGLE---HDLDDVNARWKTLNKKVAQRAAQLQEALL 3346
QD + + + ++ A E H + K L + + + + ++
Sbjct: 4754 LQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMV 4813
Query: 3347 HCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVI 3406
FQ + L W+ + ++ + ++ +I++ ++ Q + + +
Sbjct: 4814 QSIDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNAL 4873
Query: 3407 K-REGEKIATTAE--PADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHET 3463
+E EK E AD L +LS LD + L TR L I Q++++
Sbjct: 4874 SHKEKEKFTKAKELISADLEHSLAELSELDGDIQEAL---RTRQATLTEIYSQCQRYYQV 4930
Query: 3464 LEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHK---ALEDDIINHNKHLHQAVSIGQ 3520
+ N+WL ++ L+ G EE + H + ED ++ + LH V+
Sbjct: 4931 FQAANDWLEDAQE-LLQLAGNGLDVESAEENLKSHMEFFSTEDQFHSNLEELHSLVATLD 4989
Query: 3521 SLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWL 3580
L + +ED + + L+ + S ++ +LLQ+ + + E++ +
Sbjct: 4990 PLIKPTGKEDLEQKVASLELRSQ---RMSRDSGAQVDLLQRCTAQWHDYQKAREEVIELM 5046
Query: 3581 NEVHDKLSKLS-VQDYSTEGLWKQQSELRVL-------QEDILLRKQNVDQALLNGLELL 3632
N+ KLS+ S ++ S+ ++ SE + L E I+ ++ Q G +
Sbjct: 5047 NDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLEKTGNDAS 5106
Query: 3633 KQTTGDEVLIIQDKLEAIKARYKDITKLSTD-----------VAKTLEQALQLARRL--- 3678
K T + + + ++A +D K+ D V K E QL +L
Sbjct: 5107 KATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGS 5166
Query: 3679 ---HSTHEELCTWLDKVEVELLSYETQ--------------------VLKGEE------- 3708
++ EL T L+ + +L E Q GEE
Sbjct: 5167 SAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEI 5226
Query: 3709 ----------ASQAQMRPKELKKEAKNNKALLDSLN------------------EVSSAL 3740
+ + K +K+E K+ + + +N E+ + L
Sbjct: 5227 TAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQETKEYLGNPTIEIDAQL 5286
Query: 3741 LEL-----VPWRAREGLEKMVAEDNERYR-----LVSDTITQKVEEIDAAILRSQQFDQA 3790
EL R+ +EKM E E+Y L S+ Q E +R Q D+
Sbjct: 5287 EELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILPSELSLQLAEVALDLKIRDQIQDKI 5346
Query: 3791 ADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILR----HKDIIDDLVKSG 3846
+ E S T E +S +L +D T+ L K T +++ K + ++L
Sbjct: 5347 KEVEQSKATSQE---LSRQIQKLAKDLTTI-LTKLKAKTDNVVQAKTDQKVLGEELDGCN 5402
Query: 3847 HKIMTACSEEEK---------QSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFW 3897
K+M + +K + + KK+ K+ + + + R +L +A S + ++
Sbjct: 5403 SKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYN 5462
Query: 3898 ETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQ 3957
E E + W+ E +++ LR+Q H+ L E E ++ M +
Sbjct: 5463 EMLELILKWI-EKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQY 5521
Query: 3958 LLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLER 4017
L + E S Q + +T ++++ +K R L +A +F ++ ++ +LE+
Sbjct: 5522 LTSVYCTEKMSQQVAELGRET--EELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQ 5579
Query: 4018 IVERLRQPPSISAEVEK--IKEQISENKNVSVDMEKLQP------LYETLKQRGEEMIAR 4069
L P EV + +KEQ+S +++ +ME L+P L ++ + E+++A
Sbjct: 5580 AQATLTSP-----EVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVA- 5633
Query: 4070 SGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIK 4129
+A +Q++ ++ HT +++ V++ E++ + L I+
Sbjct: 5634 --SLPLCHAALRLQEEASRLQ------HTAIQQCNIMQAAVVQY-EQYEQEMKHLQQLIE 5684
Query: 4130 DTQDFIRDLEDPGIDPSVVKQQQ---EAAETIREEIDGLQEELDIVINLGSELIAACGEP 4186
R++ED + S +++ Q E + ++I G QE++ + + L
Sbjct: 5685 GAH---REIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHA 5741
Query: 4187 DKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDG-LQAVFDWVDIAGGK-- 4243
+ ++ L + L+ + A + V G + V G+
Sbjct: 5742 TMLLTVTEVEGLAEGTEDLD----GELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEG 5797
Query: 4244 ----------LASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLN------HQAEL 4287
S SP+ +V Q I AY Q + ERL H +
Sbjct: 5798 TNSEISSPPACRSPSPVANTDASVNQDI---------AYYQALSAERLQTDAAKIHPSTS 5848
Query: 4288 LLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWL 4347
++ E + + L +L+ W++L+ I +Q L AL ++Q +L + +
Sbjct: 5849 ASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKM 5908
Query: 4348 THTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTV-EAVNKAGNDLIESSAGEE 4406
E LSE G P E ++A+H L +++L Q + E + +L+ S +
Sbjct: 5909 EAIELKLSESPEPGRSP---ESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEAD 5965
Query: 4407 ASN---LQNKLEVLNQRWQNVLEKTEQRKQQLDGAL-------RQAKG---FHGEIEDLQ 4453
+ LQ+ L VL +R + K ++Q L+ L RQ + + E ++L
Sbjct: 5966 PAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELD 6025
Query: 4454 QWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPK 4513
WL T+ L + P + QL + E K L + +L
Sbjct: 6026 SWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKA 6085
Query: 4514 SAETNIDQ---DINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFI-------- 4562
+ +Q + LK ++ L++++ ++ A E S D
Sbjct: 6086 HTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQ---GTAQEKEESDVDLTATQSPGVQ 6142
Query: 4563 NWLTQAEQTLNVASRPSLILDTVLFQ-IDEHKVFANEVNSHREQIIELDKTGTHLKYFSQ 4621
WL QA T + SL L Q + E K V S E+I+ +
Sbjct: 6143 EWLAQARTTWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGE 6202
Query: 4622 KQDVVLIK--------NLLISVQSRWEKVVQRLVERGRSLDDARKRAKQ--FHEAWSKLM 4671
K DV+ + + ++ +WE + Q + + L + ++ ++ + ++L+
Sbjct: 6203 KPDVLSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLL 6262
Query: 4672 EWL--------EESEKSLDSELEIANDP-DKIKTQLAQHKEFQKSLGAKHSVYDTTNRT- 4721
+ + + ++ S L+ N +++ +Q K ++S+ + +YD + T
Sbjct: 6263 SGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAK--RQSIHLEQKLYDGVSATS 6320
Query: 4722 -------------------------------GRSLKEKTSLADDNLKL--------DDML 4742
+ +KE + D N L D
Sbjct: 6321 TWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNR 6380
Query: 4743 SELRDKWDTICGK-----SVERQ------NKLEEALLFSGQFTDALQALIDWLYRVEPQL 4791
+ D + G+ SV Q +L++ L F +L D Y + +L
Sbjct: 6381 DVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQKL 6440
Query: 4792 AE--DQPVHGDIDLVMNLIDNHKAFQK---ELGKRTSSVQALKRSARELIEGSRDDSSWV 4846
A +QPV I+ + D K F EL +R +Q + S +EL
Sbjct: 6441 ANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQEL----------- 6489
Query: 4847 KVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLR-FHGVL 4905
+L ++ + + S+++ L L ++ + L + L ++ + ++
Sbjct: 6490 ----SKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKII 6545
Query: 4906 PDDEDALRTLIDQHKEFMKKLE 4927
++ ++ L+D+HKE+ + LE
Sbjct: 6546 VSSKEEIQQLLDKHKEYFQGLE 6567
Score = 203 bits (517), Expect = 3e-51
Identities = 144/436 (33%), Positives = 219/436 (50%), Gaps = 72/436 (16%)
Query: 68 RIADERDKVQKKTFTKWINQHLMKVRKH--VNDLYEDLRDGHNLISLLEVLSGDTLPREK 125
R+ DE++ VQK+TFTKWIN HL K + V+DL+ED++DG L++LLEVLSG LP E+
Sbjct: 20 RLQDEQEIVQKRTFTKWINSHLAKRKPPMVVDDLFEDMKDGVKLLALLEVLSGQKLPCEQ 79
Query: 126 GRM--RFHRLQNVQIALDYLKRRQ-------VKLVNIRNDDITDGNPKLTLGLIWTIILH 176
GR R H + N+ AL +L+ R+ +KLVNI + DI DG P + LGL+WTIIL+
Sbjct: 80 GRRMKRIHAVANIGTALKFLEGRKSMHRGSPIKLVNINSTDIADGRPSIVLGLMWTIILY 139
Query: 177 FQISDIH-------------------VTGESEDM------------SAKERLLLWTQQAT 205
FQI ++ V+ E+ +AK+ LL W Q
Sbjct: 140 FQIEELTSNLPQLQSLSSSASSVDSIVSSETPSPPSKRKVTTKIQGNAKKALLKWVQYTA 199
Query: 206 EGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAVQSNLANLEHAFYVAE-KIGV 264
GI ++F WR G F+++IH RP+L+D+ TV +SN NLE AF +AE ++G+
Sbjct: 200 GKQTGIEVKDFGKSWRSGVAFHSVIHAIRPELVDLETVKGRSNRENLEDAFTIAETELGI 259
Query: 265 IRLLDPEDVDVSSPDEKSVITYVSSLYDAFPKVPEGG-EGIGANDVEVKWIEYQNMVNYL 323
RLLDPEDVDV PDEKS++TYV+ +P + +G +++ + + N V
Sbjct: 260 PRLLDPEDVDVDKPDEKSIMTYVAQFLKHYPDIHNASTDGQEDDEILPGFPSFANSVQNF 319
Query: 324 IQWIRHHVTTMS------ERTFPNNPVELKALYNQYLQFKETEIPPKETEKSKIKRLYKL 377
+ R M ER + L ++Y FK + + K K++ L
Sbjct: 320 KREDRVIFKEMKVWIEQFERDLTRAQMVESNLQDKYQSFKHFRV----QYEMKRKQIEHL 375
Query: 378 LEIWIEFGRIKLLQGYHPNDIEK------EW------------GKLIIAMLEREKALRPE 419
++ G++ L Q ++ +W G + + E ALR E
Sbjct: 376 IQPLHRDGKLSLDQALVKQSWDRVTSRLFDWHIQLDKSLPAPLGTIGAWLYRAEVALREE 435
Query: 420 VERLEMLQQIANRVQR 435
+ ++ ++ AN +QR
Sbjct: 436 ITVQQVHEETANTIQR 451
Score = 159 bits (401), Expect = 1e-37
Identities = 417/2207 (18%), Positives = 833/2207 (37%), Gaps = 317/2207 (14%)
Query: 1049 LSNLQSRFEDFLEDSQESQV-FSGSDITQLEKEVNVC-KQYYQELLKSAEREEQEESVYN 1106
L+ Q + L+D + + S SD+ ++ C ++ K R E +
Sbjct: 6668 LNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWT 6727
Query: 1107 LYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTI 1166
Y SE ++ L++ +DRL F + + +ELE ++D L
Sbjct: 6728 RYQSESADLIHWLQSAKDRL----------------EFWTQQSVTVPQELEMVRDHLNAF 6771
Query: 1167 TNKCEEFFSQAAASSSV---------------PTLRSELNVVLQNMNQVYSMSSTYIDKL 1211
+E +Q++ SSV TLRSEL+ + + + +KL
Sbjct: 6772 LEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKL 6831
Query: 1212 KTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLIS---------TLKQWRSEV 1262
L + + A+ ++ E + D++NI+N I K ++ ++
Sbjct: 6832 H--QLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDI 6889
Query: 1263 DEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRL 1322
+ K+ + Q IS + ++ + DF E+ + + WQ + + ++
Sbjct: 6890 NCKQLTVDFVN---QSVLQISSQDVESKRSDKTDF---AEQLGAMNKSWQILQGLVTEKI 6943
Query: 1323 RDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIE 1382
+ LEG+ +S Y + L W + E +R Q+++ + ++ L + L I+
Sbjct: 6944 QLLEGLLESWSEYENNVQCLKTWFETQE--KRLKQQHRIGDQASVQNALKDCQDLEDLIK 7001
Query: 1383 MKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMD 1442
K+ ++++ ++ K+ ++ ++ + + Q + M ++++ +D
Sbjct: 7002 AKEKEVEKIEQNGLALIQNKKE-DVSSIVMSTLRELGQ-TWANLDHMVGQLKILLKSVLD 7059
Query: 1443 LRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKD 1502
+ + + Y+ A SL R SLE +Q V N+ D
Sbjct: 7060 QWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEA-----------VQVQVDNLQNLQDD 7108
Query: 1503 AEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQ 1562
EK + S QK S KE +T L +K +
Sbjct: 7109 LEKQER---SLQKFGSITNQLLKECHPPVTET-------------------LTNTLKEVN 7146
Query: 1563 ESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQE 1622
+N L E +QLQ S K + + Q YK+ + + Q E+R
Sbjct: 7147 MRWNNLLEEIAEQLQSS----------KALLQLWQRYKDYSKQCASTVQQQEDR------ 7190
Query: 1623 AFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEV------VKNTENFLKENGEKLSQED 1676
T EL K + ++ ++ Q ++ VK++ FL E GE+L Q+
Sbjct: 7191 -------TNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQV 7243
Query: 1677 KALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENL 1736
A + ++ Q EQ+ K++T A V E +E L
Sbjct: 7244 DASAASAIQSDQLSLSQHLCALEQA----------LCKQQTSLQAGVLDYETFAKSLEAL 7293
Query: 1737 LDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTT 1796
W+ ++ + H + T
Sbjct: 7294 EAWIVEAEEILQGQDPSHSS-----------------------------------DLSTI 7318
Query: 1797 QENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKV 1856
QE + +++K Q K S + L + G L +KE K M+ L
Sbjct: 7319 QERM----EELKGQMLKFSSMAPDLD--------RLNELGYRLPLNDKEI--KRMQNLNR 7364
Query: 1857 HYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTK 1916
H+ +++ ++ S + + F + +L Q+EQ+L +G + L+ +
Sbjct: 7365 HWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISG--NYQHLLEQ 7422
Query: 1917 LKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHAT 1976
+ + F ++ S + L I I G R+LE G+VD E KL +
Sbjct: 7423 QRAHELFQAEMFSRQQILHSIIIDGQRLLEQ---------GQVDD---RDEFNLKLTLLS 7470
Query: 1977 DRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHL-SEPIAVDPKN 2035
++++ + + + + ++Q Y + + L L L S PI +
Sbjct: 7471 NQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQAR 7530
Query: 2036 L---QRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRY 2092
+ Q +E L+ Q S + VE K ++LL A A+ +Q L +I ++
Sbjct: 7531 TLFDEVQFKEKVFLRQQ-GSYILTVEAGK---QLLLSADSG---AEAALQAELAEIQEKW 7583
Query: 2093 EDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIIS 2152
+ S + E+ +KL L + G+ + L+ + + L + +P + L
Sbjct: 7584 KSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQS--LPDHHEELHAEQM 7641
Query: 2153 KNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETL 2212
+ LE + + ++ S L +++ L ++ E H +
Sbjct: 7642 RCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCH---QLS 7698
Query: 2213 AKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTE-----LSQYMQESTSEF 2267
+ +++ ++ + SEK + E TQ ++V G + E L + QE +
Sbjct: 7699 LRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLKKDYQEEIAIA 7758
Query: 2268 LEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEM-EDTIKEKKEAVTSCQE 2326
E+K L+ + L + S S+ L K N+ + ++ +K+ KE + + Q
Sbjct: 7759 QENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQ- 7817
Query: 2327 QLDAFQVLVKSLKSWIKETTKKV--PIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQK 2384
QLD + SL++W+ ++ PIV S +E++ + L + ++LQ +I+K
Sbjct: 7818 QLDKN---MSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQR-------DIEK 7867
Query: 2385 VNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDI 2444
+ S+ NL + A A T+ E SI++ ++
Sbjct: 7868 HSTGVASVLNLCEVLLHDCDACA---------------TDAE-------CDSIQQATRNL 7905
Query: 2445 SHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEA 2504
+ ++ + ++ ++ QK ++ S WL+ +TA + + T A
Sbjct: 7906 DRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAA-FPSSSGVIYTVA 7964
Query: 2505 VKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELN 2564
K ++++ ++F+ ++ + + +++ + + L EN T A KQM+ E + +W L
Sbjct: 7965 -KEELKKFEAFQRQVHECLTQLELINKQYRRLARENR-TDSACSLKQMVHEGNQRWDNLQ 8022
Query: 2565 QLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQI 2624
+ ++L+ +F+T + WL E +L ++ + S + + +Q++
Sbjct: 8023 KRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECD--VQAKIKQLKA 8080
Query: 2625 LLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDW 2684
QE + + EQ+ A G+ ++ + +P I++E+L + + + G++
Sbjct: 8081 FQQEISLNHNKIEQIIAQGEQLIEK--SEPLDAAIIEEELDELRRYCQEVFGRVERYHKK 8138
Query: 2685 IDQAIVKSTQYQSLLRSL----SDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEI 2740
+ + + ++ R L S LSDL S+ ++ + + N L AQ ++ E
Sbjct: 8139 LIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSER 8198
Query: 2741 QQEKKQIKVAQALCE-----DLSALVKEEYLKAELSRQLEGILKSFKD------------ 2783
V E DLS ++ +A S EG + KD
Sbjct: 8199 SGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEG--QDDKDFYLRGAVGLSDV 8256
Query: 2784 -VEQKAENHVQHLQSAC--------ASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLD 2834
+ + E +V+ ++A A Q +Q+ + D++ + Q + I +K
Sbjct: 8257 MIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALD---DSRFQIQQTENIIRSKTP 8313
Query: 2835 VLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKT-----N 2889
L +K + K L S + ++ E+ L + + S + L +T
Sbjct: 8314 TGPELDTSYKGYMKLLGECSSSID-SVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDR 8372
Query: 2890 WDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEE---IKFCLDPAEGEN 2946
W+ Q +E ++K++L+K ++ + ++W W+ + LE+ ++ D E
Sbjct: 8373 WELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIEL 8432
Query: 2947 SIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHS 3006
I KLK LQK +D ++ +N + + + D + + D V L
Sbjct: 8433 QIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEE 8492
Query: 3007 KKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQ 3066
+ L++ + + F E+S L E +D + SN +LQ K L
Sbjct: 8493 WRGLLQDALMQCQGFHEMS----HGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLM 8548
Query: 3067 ALKHQV---DLAKRLAQDLVVE-ASDSKGTS--DVLLQVETIAQEHSTLSQQVDEKCSFL 3120
+KH++ L QD+ + +++GT + +V I L ++V L
Sbjct: 8549 QIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKEL 8608
Query: 3121 ETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPV----GRDAETLQK 3163
E KL + Q + S DELD+ V GR QK
Sbjct: 8609 E-KLLDVSSSQQDLSSWSSA-----DELDTSGSVSPTSGRSTPNRQK 8649
>gi|5902122 spectrin, beta, non-erythrocytic 2 [Homo sapiens]
Length = 2390
Score = 315 bits (806), Expect = 1e-84
Identities = 182/406 (44%), Positives = 250/406 (61%), Gaps = 15/406 (3%)
Query: 69 IADERDKVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEVLSGDTLPRE-KGR 127
+ADER+ VQKKTFTKW+N HL +V V DLY DLRDG NL+ LLEVLSG+ LP+ KGR
Sbjct: 51 LADEREAVQKKTFTKWVNSHLARVTCRVGDLYSDLRDGRNLLRLLEVLSGEILPKPTKGR 110
Query: 128 MRFHRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIHVTGE 187
MR H L+NV AL +LK ++V L N+ + DI DGN +LTLGL+WTIIL FQI DI V E
Sbjct: 111 MRIHCLENVDKALQFLKEQKVHLENMGSHDIVDGNHRLTLGLVWTIILRFQIQDISVETE 170
Query: 188 S--EDMSAKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAV 245
E SAK+ LLLW Q T GY + NFTT WRDG FNAI+HK+RPDL+D ++
Sbjct: 171 DNKEKKSAKDALLLWCQMKTAGYPNVNVHNFTTSWRDGLAFNAIVHKHRPDLLDFESLKK 230
Query: 246 QSNLANLEHAFYVAEK-IGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAFPKVPE---GG 301
+ NL++AF +AEK +G+ +LLDPEDV+V PDEKS+ITYV++ Y F K+ G
Sbjct: 231 CNAHYNLQNAFNLAEKELGLTKLLDPEDVNVDQPDEKSIITYVATYYHYFSKMKALAVEG 290
Query: 302 EGIG-----ANDVEVKWIEYQNMVNYLIQWIRHHVTTMSERTFPNNPVELKALYNQYLQF 356
+ IG A + E +Y+++ + L+QWI + T+++R N+ ++ + +
Sbjct: 291 KRIGKVLDHAMEAERLVEKYESLASELLQWIEQTIVTLNDRQLANSLSGVQNQLQSFNSY 350
Query: 357 KETEIPPKETEKSKIKRLYKLLEIWIEFGRIKLL---QGYHPNDIEKEWGKLIIAMLERE 413
+ E PPK TEK ++ L ++ + K+ +G +DI K W +L A ERE
Sbjct: 351 RTVEKPPKFTEKGNLEVLLFTIQSKLRANNQKVYTPREGRLISDINKAWERLEKAEHERE 410
Query: 414 KALRPEVERLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLE 459
ALR E+ R E L+Q+A R R + + E L + D+ LE
Sbjct: 411 LALRTELIRQEKLEQLAARFDRKAAMRETWLSENQRLVSQDNFGLE 456
Score = 159 bits (403), Expect = 6e-38
Identities = 343/1769 (19%), Positives = 687/1769 (38%), Gaps = 166/1769 (9%)
Query: 3332 KKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKL 3391
K++ + EA +++ LL W+ T + N + + V+ Q+Q
Sbjct: 291 KRIGKVLDHAMEAERLVEKYESLASELLQWIEQTI-VTLNDRQLANSLSGVQNQLQSFNS 349
Query: 3392 LQRLLDDRKST----VEVI--------KREGEKIATTAEP---ADKVKILKQLSLLDSRW 3436
+ + K T +EV+ + +K+ T E +D K ++L +
Sbjct: 350 YRTVEKPPKFTEKGNLEVLLFTIQSKLRANNQKVYTPREGRLISDINKAWERLEKAEHER 409
Query: 3437 EALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIA 3496
E L R +LE + A +F WL+ +RLV+ + G + + +E +
Sbjct: 410 ELALRTELIRQEKLEQL---AARFDRKAAMRETWLSE-NQRLVSQDNFGLELAAVEAAVR 465
Query: 3497 QHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRS 3556
+H+A+E DI+ ++ + ++ L + K + + + +++W +++ +R
Sbjct: 466 KHEAIETDIVAYSGRVQAVDAVAAELAAERYHDIKRIAARQHNVARLWDF-LRQMVAARR 524
Query: 3557 ELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILL 3616
E L L K+F +D + LM+W+ E+ +L + + G+ +++ DI +
Sbjct: 525 ERLLLNLELQKVF-QDLLYLMDWMEEMKGRLQSQDLGRHLA-GVEDLLQLHELVEADIAV 582
Query: 3617 RKQNVDQALLNGLELL---KQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQ 3673
+ + V + L K+ + ++ +++ ++ Y+ + +L+ LE++ +
Sbjct: 583 QAERVRAVSASALRFCNPGKEYRPCDPQLVSERVAKLEQSYEALCELAAARRARLEESRR 642
Query: 3674 LARRLHSTHEELCTWLDKVEVELLSYET--------QVLKGEEASQAQM--RPKELKKEA 3723
L R L E W+ + + L S +T ++L A + +M R LK
Sbjct: 643 LWRFLWEVGEAEA-WVREQQHLLASADTGRDLTGALRLLNKHTALRGEMSGRLGPLKLTL 701
Query: 3724 KNNKALL----DSLNEVSSALLEL-VPWRAREGLEKMVAEDNERYRLVSDTITQKVEEID 3778
+ + L+ ++ S+ EL W E LE + E +R
Sbjct: 702 EQGQQLVAEGHPGASQASARAAELQAQW---ERLEALAEERAQRLA-------------Q 745
Query: 3779 AAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDI 3838
AA L Q D A D E +W+ + +L+S ++ ++ T A + + EI H+
Sbjct: 746 AASLYQFQAD-ANDME-AWLVDA-LRLVSSPELGHDEFSTQALARQHRALEEEIRSHRPT 802
Query: 3839 IDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWE 3898
+D L + + S + ++ ++ + ++Y+ + ER LE A +L E
Sbjct: 803 LDALREQAAALPPTLSRTPE--VQGRVPTLERHYEELQARAGERARALEAALALYTMLSE 860
Query: 3899 TYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQL 3958
W+ E + ++ L P E L Q+ L + I +N QL
Sbjct: 861 A-GACGLWVEEKEQWLNGLALPE-RLEDLEVVQQRFETLEPEMNTLAAQITAVNDIAEQL 918
Query: 3959 LELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQI---LESL 4015
L+ +P I + + Q + + AL A+S +H + + +
Sbjct: 919 LKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALTSALSIQN-YHLECTETQAWMREK 977
Query: 4016 ERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDK 4075
+++E + + A V ++ +++ + D+E + L + + A
Sbjct: 978 TKVIESTQGLGNDLAGVLALQRKLAGTER---DLEAIAARVGELTREANALAA-----GH 1029
Query: 4076 DISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFI 4135
A A+ +L ++ WE++ + RE L + L + F + TQ +
Sbjct: 1030 PAQAVAINARLREVQTGWEDLRATMRRREESLGEARRLQD-FLRSLDDFQAWLGRTQTAV 1088
Query: 4136 RDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSI 4195
E P P + A +R E++ Q E + LG E+ +P +++ +
Sbjct: 1089 ASEEGPATLPEAEALLAQHA-ALRGEVERAQSEYSRLRALGEEVTRDQADPQCLFLRQRL 1147
Query: 4196 DELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLE 4255
+ L + W+ L + W+ R +L +A +D QA + V + + S + + L+
Sbjct: 1148 EALGTGWEELGRMWESRQGRLAQAHGFQGFLRDARQA--EGVLSSQEYVLSHTEMPGTLQ 1205
Query: 4256 TVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSL 4315
I++L+ F S + L L+ + +DK ++ DS+
Sbjct: 1206 AADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSEGNIHADK---------IREKADSI 1256
Query: 4316 EERIINRQHKLE---GALLALGQFQHALD---ELLAWLTHTEGLLSEQKPVGGDPKAIEI 4369
E R Q + G L + QH L EL W+ E +L+ Q + + +
Sbjct: 1257 ERRHKKNQDAAQQFLGRLRDNREQQHFLQDCHELKLWI--DEKMLTAQDVSYDEARNLHT 1314
Query: 4370 ELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTE 4429
+ KH ++ A++ ++ V+K G +L E + + KL L++RW LE T
Sbjct: 1315 KWQKHQAFMAELAANKDWLDKVDKEGRELTLEKP-ELKALVSEKLRDLHRRWDE-LETTT 1372
Query: 4430 QRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLA---SKPLGGLPETAKEQLNVHMEV 4486
Q K + +A+ F L+ WL + L + K L + K+Q + E+
Sbjct: 1373 QAKARSLFDANRAELFAQSCCALESWLESLQAQLHSDDYGKDLTSVNILLKKQQMLEWEM 1432
Query: 4487 CA---AFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTK 4543
EA + K+L Q+ Q +++ ++EK+ ++ + ER +
Sbjct: 1433 AVREKEVEAIQAQAKALAQEDQ---------GAGEVERTSRAVEEKFRALCQPMRERCRR 1483
Query: 4544 LEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHR 4603
L +A +FH ++D I W+T+ + + L +V + +++ E+ H
Sbjct: 1484 L-QASREQHQFHRDVEDEILWVTE-RLPMASSMEHGKDLPSVQLLMKKNQTLQKEIQGHE 1541
Query: 4604 EQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQF 4663
+I +L + L + + L +Q W+++ L RG+ L+DA RA+QF
Sbjct: 1542 PRIADLRERQRALGAAAAGPE-------LAELQEMWKRLGHELELRGKRLEDA-LRAQQF 1593
Query: 4664 HEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGR 4723
+ ++ W+ E E + + E A D + ++ +H+ +++L + +
Sbjct: 1594 YRDAAEAEAWMGEQELHMMGQ-EKAKDELSAQAEVKKHQVLEQALADYAQTIHQLAASSQ 1652
Query: 4724 SL-----KEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQ 4778
+ E T ++ ++D + + L++ + G ER+ +L+E L Q L
Sbjct: 1653 DMIDHEHPESTRISIRQAQVDKLYAGLKE----LAG---ERRERLQEHLRLC-QLRRELD 1704
Query: 4779 ALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELG----KRTSSVQALKRSARE 4834
L W+ E +A + D + V L D + F ++ +R S AL A
Sbjct: 1705 DLEQWIQERE-VVAASHELGQDYEHVTMLRDKFREFSRDTSTIGQERVDSANAL---ANG 1760
Query: 4835 LIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAE 4894
LI G + V L+ W + L ++ L AA H AL +
Sbjct: 1761 LIAGGHAARATVAEWKDSLNEAWADLLELLDTRGQVLAAAYELQRFLHGARQALARVQHK 1820
Query: 4895 AEQTLRFHGVLPD----DEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPD 4950
+Q LPD D +A L +H + ++ ++ + G + D
Sbjct: 1821 QQQ-------LPDGTGRDLNAAEALQRRHCAYEHDIQALSPQVQQVQDDGHRLQKAYAGD 1873
Query: 4951 SITTIKHWITIIRARFEEVLAWAKQHQQRLA--SALAGLIAKQELLEALLAWLQWAETTL 5008
I + + AWA+ A L K +A+ + W +
Sbjct: 1874 KAEEIGRHMQAVAE------AWAQLQGSSAARRQLLLDTTDKFRFFKAVRELMLWMDEVN 1927
Query: 5009 TDKDKEVIPQEIEEVKALIAEHQTFMEEM 5037
D + P+++ +I Q E+
Sbjct: 1928 LQMDAQERPRDVSSADLVIKNQQGIKAEI 1956
Score = 137 bits (346), Expect = 2e-31
Identities = 334/1869 (17%), Positives = 710/1869 (37%), Gaps = 224/1869 (11%)
Query: 3214 KQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQ 3273
K+ K+LD A E VE E +++ + L + + + G++ + Q
Sbjct: 291 KRIGKVLDHAMEAERLVEKYESLASELLQWIEQTIVTLN---DRQLANSLSGVQNQL--Q 345
Query: 3274 QLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKK 3333
N ++ +K +G + + + Q +++ + T + D+N W+ L K
Sbjct: 346 SFNSYRTVEKPPKFTEKGNLEVLLFTIQSKLRANNQKVYTPREGRLISDINKAWERLEKA 405
Query: 3334 VAQRAAQLQEALLH-------CGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQI 3386
+R L+ L+ RF +W+ + + LV +Q E V+A +
Sbjct: 406 EHERELALRTELIRQEKLEQLAARFDRKAAMRETWLSENQRLV-SQDNFGLELAAVEAAV 464
Query: 3387 QEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVK-ILKQLSLLDSRWEALLNKAET 3445
++ + ++ + V+ + ++A AE +K I + + W+ L
Sbjct: 465 RKHEAIETDIVAYSGRVQAVDAVAAELA--AERYHDIKRIAARQHNVARLWDFLRQMVAA 522
Query: 3446 RNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDI 3505
R +L +++ Q+ + L L +W+ ++ RL + +G + +E+ + H+ +E DI
Sbjct: 523 RRERLL-LNLELQKVFQDLLYLMDWMEEMKGRL-QSQDLGRHLAGVEDLLQLHELVEADI 580
Query: 3506 INHNKHLHQAVSIGQSLKVLSSRE----DKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQ 3561
+ + +AVS +E D +V ++ + Y + E + +R L++
Sbjct: 581 AVQAERV-RAVSASALRFCNPGKEYRPCDPQLVSERVAKLEQSYEALCELAAARRARLEE 639
Query: 3562 ALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNV 3621
+ + E E W+ E L+ T LR+L + LR +
Sbjct: 640 SRRLWRFLWE-VGEAEAWVREQQHLLASADTGRDLT-------GALRLLNKHTALRGE-- 689
Query: 3622 DQALLNGLELLKQTTGDEVLIIQD----------KLEAIKARYKDITKLSTDVAKTLEQA 3671
+ L LK T ++ + + ++A+++ + L+ + A+ L QA
Sbjct: 690 ---MSGRLGPLKLTLEQGQQLVAEGHPGASQASARAAELQAQWERLEALAEERAQRLAQA 746
Query: 3672 LQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRP-KELKKEAKNNKALL 3730
L + + ++ WL V+ L ++ E ++QA R + L++E ++++ L
Sbjct: 747 ASL-YQFQADANDMEAWL--VDALRLVSSPELGHDEFSTQALARQHRALEEEIRSHRPTL 803
Query: 3731 DSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQA 3790
D+L E ++AL + R E ++ V Y + ++ ++AA+ +A
Sbjct: 804 DALREQAAALPPTLS-RTPE-VQGRVPTLERHYEELQARAGERARALEAALALYTMLSEA 861
Query: 3791 ADAELSWITETEKKLMSLG------DIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVK 3844
L W+ E E+ L L D+ + Q + T +I DI + L+K
Sbjct: 862 GACGL-WVEEKEQWLNGLALPERLEDLEVVQQRFETLEPEMNTLAAQITAVNDIAEQLLK 920
Query: 3845 SGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELW 3904
+ + K + +++ + ++ + L A S+ N E E
Sbjct: 921 A--------NPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALTSALSIQNYHLEC-TETQ 971
Query: 3905 PWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPG 3964
W+ E +I + + Q + + + ++ + L P
Sbjct: 972 AWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGELTREANALAAGHPA 1031
Query: 3965 EGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERL-- 4022
+ +I + T + ++ +++R +L EA + F +D L R +
Sbjct: 1032 QAVAINARLREVQTGWEDLRATMRRREESLGEA-RRLQDFLRSLDDFQAWLGRTQTAVAS 1090
Query: 4023 RQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAV 4082
+ P+ E E + ++++ + ++E+ Q Y L+ GEE+ D +
Sbjct: 1091 EEGPATLPEAEAL---LAQHAALRGEVERAQSEYSRLRALGEEVTR----DQADPQCLFL 1143
Query: 4083 QDKLDQMVFIWENIHTLVEEREAKLLDV---------------MELAEKFWCDHMSLIVT 4127
+ +L+ + WE + + E R+ +L + ++++ H + T
Sbjct: 1144 RQRLEALGTGWEELGRMWESRQGRLAQAHGFQGFLRDARQAEGVLSSQEYVLSHTEMPGT 1203
Query: 4128 -------IKDTQDFIRDLEDPG--------IDPSVVKQQQEAAETIREEIDGLQEELDIV 4172
IK +DF+ ++ G +V + A+ IRE+ D ++
Sbjct: 1204 LQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSEGNIHADKIREKADSIERRHKKN 1263
Query: 4173 INLGSELIAACGE--------PDKPIVKKSIDE---------------LNSAWD------ 4203
+ + + + D +K IDE L++ W
Sbjct: 1264 QDAAQQFLGRLRDNREQQHFLQDCHELKLWIDEKMLTAQDVSYDEARNLHTKWQKHQAFM 1323
Query: 4204 ---SLNKAWKDRIDK-----------------------------LEEAMQA--------- 4222
+ NK W D++DK LE QA
Sbjct: 1324 AELAANKDWLDKVDKEGRELTLEKPELKALVSEKLRDLHRRWDELETTTQAKARSLFDAN 1383
Query: 4223 -AVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERL 4281
A + A+ W++ +L S G DL +V +++ + + E ++ E+E +
Sbjct: 1384 RAELFAQSCCALESWLESLQAQLHS-DDYGKDLTSVNILLKKQQMLEWEMAVREKEVEAI 1442
Query: 4282 NHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALD 4341
QA+ L + E+ V+ ++ + +L + + R +L+ A QF ++
Sbjct: 1443 QAQAKALAQ---EDQGAGEVERTSRAVEEKFRALCQPMRERCRRLQ-ASREQHQFHRDVE 1498
Query: 4342 ELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIES 4401
+ + W+T + S + G D ++++ + K+ LQ ++ H+ + + + L +
Sbjct: 1499 DEILWVTERLPMASSMEH-GKDLPSVQLLMKKNQTLQKEIQGHEPRIADLRERQRALGAA 1557
Query: 4402 SAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTER 4461
+AG E + LQ + W+ + + E R ++L+ ALR A+ F+ + + + W+ + E
Sbjct: 1558 AAGPELAELQ-------EMWKRLGHELELRGKRLEDALR-AQQFYRDAAEAEAWMGEQEL 1609
Query: 4462 HLLASKPLGGLPETAKEQLNVHMEVC------AAFEAKEETYKSLMQKGQQML-ARCPKS 4514
H++ E AK++L+ EV A +T L Q M+ P+S
Sbjct: 1610 HMMGQ-------EKAKDELSAQAEVKKHQVLEQALADYAQTIHQLAASSQDMIDHEHPES 1662
Query: 4515 AETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNV 4574
+I Q + + + ++ ER+ +L+E L L + L D W+ Q + +
Sbjct: 1663 TRISIRQ--AQVDKLYAGLKELAGERRERLQEHLRLC-QLRRELDDLEQWI-QEREVVAA 1718
Query: 4575 ASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLIS 4634
+ + V D+ + F+ + ++ ++ ++ + + S
Sbjct: 1719 SHELGQDYEHVTMLRDKFREFSRDTSTIGQERVDSANALANGLIAGGHAARATVAEWKDS 1778
Query: 4635 VQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKI 4694
+ W +++ L RG+ L A + + H A L + ++ D D +
Sbjct: 1779 LNEAWADLLELLDTRGQVLAAAYELQRFLHGARQALARVQHKQQQLPDG---TGRDLNAA 1835
Query: 4695 KTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICG 4754
+ +H ++ + A G L +K D ++ + + + W + G
Sbjct: 1836 EALQRRHCAYEHDIQALSPQVQQVQDDGHRL-QKAYAGDKAEEIGRHMQAVAEAWAQLQG 1894
Query: 4755 KSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQL-AEDQPVHGDIDLVMNLIDNHKA 4813
S R+ L + +F A++ L+ W+ V Q+ A+++P D+ +I N +
Sbjct: 1895 SSAARRQLLLDT-TDKFRFFKAVRELMLWMDEVNLQMDAQERP--RDVSSADLVIKNQQG 1951
Query: 4814 FQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEA 4873
+ E+ R + +EL+ S + + ++ +L R + K L+
Sbjct: 1952 IKAEIEARADRFSSCIDMGKELLARSHYAAEEISEKLSQLQARRQETAEKWQEKMDWLQL 2011
Query: 4874 ALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKL---EEKR 4930
L + F WL E +R L D + +LI +H+ F K EE+
Sbjct: 2012 VL-EVLVFGRDAGMAEAWLCSQEPLVR-SAELGCTVDEVESLIKRHEAFQKSAVAWEERF 2069
Query: 4931 AELNKATTM 4939
L K T +
Sbjct: 2070 CALEKLTAL 2078
Score = 118 bits (296), Expect = 1e-25
Identities = 204/1007 (20%), Positives = 402/1007 (39%), Gaps = 89/1007 (8%)
Query: 4093 WENIHTLVEEREAKLLDVM-------ELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDP 4145
WE + ERE L + +LA +F + + Q + ++ G++
Sbjct: 399 WERLEKAEHERELALRTELIRQEKLEQLAARFDRKAAMRETWLSENQRLVSQ-DNFGLEL 457
Query: 4146 SVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSL 4205
+ V+ E I +I + V + +EL A K I + + WD L
Sbjct: 458 AAVEAAVRKHEAIETDIVAYSGRVQAVDAVAAELAAERYHDIKRIAARQ-HNVARLWDFL 516
Query: 4206 NKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELK 4265
+ R ++L ++ +QD L + DW++ G+L S +G L V+ ++ +
Sbjct: 517 RQMVAARRERLLLNLELQKVFQD-LLYLMDWMEEMKGRLQSQD-LGRHLAGVEDLLQLHE 574
Query: 4266 QFKSEAYQQQIEMERLNHQAELLLK-----KVTEESDKHTVQDPLMELKLIWDSLEERII 4320
+++ ++ ER+ + L+ K D V + + +L+ +++L E
Sbjct: 575 LVEADI---AVQAERVRAVSASALRFCNPGKEYRPCDPQLVSERVAKLEQSYEALCELAA 631
Query: 4321 NRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQND 4380
R+ +LE + L +F + E AW+ + LL+ G D L KH L+ +
Sbjct: 632 ARRARLEESR-RLWRFLWEVGEAEAWVREQQHLLASAD-TGRDLTGALRLLNKHTALRGE 689
Query: 4381 VLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALR 4440
+ ++ + G L+ + AS + L +W+ + E+R Q+L A
Sbjct: 690 MSGRLGPLKLTLEQGQQLV-AEGHPGASQASARAAELQAQWERLEALAEERAQRLAQAAS 748
Query: 4441 QAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSL 4500
+ F + D++ WL D R L++S LG + + H + + T +L
Sbjct: 749 LYQ-FQADANDMEAWLVDALR-LVSSPELGHDEFSTQALARQHRALEEEIRSHRPTLDAL 806
Query: 4501 MQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQD 4560
++ + ++ E + + L+ +E ++ + ER LE AL L +
Sbjct: 807 REQAAALPPTLSRTPE--VQGRVPTLERHYEELQARAGERARALEAALALYTMLSEAGAC 864
Query: 4561 FINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHL-KYF 4619
+ W+ + EQ LN + P + D + Q + E+N+ QI ++ L K
Sbjct: 865 GL-WVEEKEQWLNGLALPERLEDLEVVQ-QRFETLEPEMNTLAAQITAVNDIAEQLLKAN 922
Query: 4620 SQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEK 4679
+D ++ N + RW++ +RL + ++ + + +H ++ W+ E K
Sbjct: 923 PPGKDRIV--NTQEQLNHRWQQF-RRLADGKKAALTSALSIQNYHLECTETQAWMREKTK 979
Query: 4680 SLDSELEIANDPDKIKTQLAQHKEFQKSL-GAKHSVYDTTNRTGRSLKEKTSLADDN--- 4735
++S + ND LA Q+ L G + + R G +E +LA +
Sbjct: 980 VIESTQGLGND-------LAGVLALQRKLAGTERDLEAIAARVGELTREANALAAGHPAQ 1032
Query: 4736 -LKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALID---WLYRVEPQL 4791
+ ++ L E++ W+ + R+ L EA + D L++L D WL R + +
Sbjct: 1033 AVAINARLREVQTGWEDLRATMRRREESLGEAR----RLQDFLRSLDDFQAWLGRTQTAV 1088
Query: 4792 AEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSS-WVKVQM 4850
A ++ + L+ H A + E+ + S L+ E+ D +++ ++
Sbjct: 1089 ASEEGP-ATLPEAEALLAQHAALRGEVERAQSEYSRLRALGEEVTRDQADPQCLFLRQRL 1147
Query: 4851 QELSTRWETVCALSISKQTRLEAA------LRQAEEFHSVVHALLEWLAEAEQTLRFHGV 4904
+ L T WE + + S+Q RL A LR A + V+ +++ + H
Sbjct: 1148 EALGTGWEELGRMWESRQGRLAQAHGFQGFLRDARQAEGVL--------SSQEYVLSHTE 1199
Query: 4905 LPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAI--CHPDSITTIKHWITII 4962
+P A I + ++FM ++ ++ G +++ H D I
Sbjct: 1200 MPGTLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSEGNIHADKI---------- 1249
Query: 4963 RARFEEVLAWAKQHQ---QRLASALAGLIAKQELLE---ALLAWLQWAETTLTDKDKEVI 5016
R + + + K++Q Q+ L +Q L+ L W+ E LT +D V
Sbjct: 1250 REKADSIERRHKKNQDAAQQFLGRLRDNREQQHFLQDCHELKLWID--EKMLTAQD--VS 1305
Query: 5017 PQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQS 5063
E + +HQ FM E+ + +DKV K + + L++
Sbjct: 1306 YDEARNLHTKWQKHQAFMAELAANKDWLDKVDKEGRELTLEKPELKA 1352
Score = 110 bits (275), Expect = 4e-23
Identities = 360/1904 (18%), Positives = 717/1904 (37%), Gaps = 276/1904 (14%)
Query: 2061 KKTAEVLLDARGSLLPAKNDIQKT------LDDIVGRYEDLSKSVNERNEKLQITLTRSL 2114
K EVLL S L A N T + DI +E L K+ +ER L+ L R
Sbjct: 362 KGNLEVLLFTIQSKLRANNQKVYTPREGRLISDINKAWERLEKAEHERELALRTELIRQE 421
Query: 2115 SVQ------DGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSI 2168
++ D M + + L Q L A++ + K+ +E DI +
Sbjct: 422 KLEQLAARFDRKAAMRETWLSENQRLVSQDNFGLELAAVEAAVRKHEAIETDIVAYSGRV 481
Query: 2169 NAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHK----HKETLAKMEELKTKVEL 2224
A++ + A+ +K ++AR + + A+ E L +EL
Sbjct: 482 QAVDAVAAEL--------AAERYHDIKRIAARQHNVARLWDFLRQMVAARRERLLLNLEL 533
Query: 2225 ---FENLSEKLQTFLETK----TQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVL 2277
F++L + E K +Q L +D+ +L + ++ + E + +
Sbjct: 534 QKVFQDLLYLMDWMEEMKGRLQSQDLGRHLAGVEDLLQLHELVEADIAVQAERVRAVSAS 593
Query: 2278 HSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKS 2337
P D LV E+ L + ++ + + ++ + + +L F V
Sbjct: 594 ALRFCNPGKEYRPCDPQLVSERVAKLEQSYEALCELAAARRARLEESR-RLWRFLWEVGE 652
Query: 2338 LKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLIS 2397
++W++E Q + D G+ L +L K + E+ S
Sbjct: 653 AEAWVREQ-------QHLLASADTGRDLTGALRLLNKHTALRGEM--------------S 691
Query: 2398 AVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKD 2457
P K G L EG + G + ++ +E L L ++
Sbjct: 692 GRLGPLKLTL---EQGQQLVAEG----------HPGASQASARAAELQAQWERLEALAEE 738
Query: 2458 KIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEA 2517
+ L + + L + Q +++ M WL + + + T+A+ Q+++ E
Sbjct: 739 RAQRL-AQAASLYQFQADANDMEAWLVDALRLVSSPELGHDEFSTQAL---ARQHRALEE 794
Query: 2518 ELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEES 2577
E++ + + L+++ L TPE + + ++ ++EL +R + LE +
Sbjct: 795 EIRSHRPTLDALREQAAALPPTLSRTPEV---QGRVPTLERHYEELQARAGERARALEAA 851
Query: 2578 SNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYE 2637
T A W+ EKE ++ L L + + ++++ Q F T +P+
Sbjct: 852 LALYTMLSEAGA-CGLWVEEKEQWLNGLA--------LPERLEDLEVVQQRFETLEPEMN 902
Query: 2638 QLTAAGQGI---------LSRPGEDPSLRGIVKEQLAAVTQKWD--------SLTGQLSD 2680
L A + + PG+D + +EQL Q++ +LT LS
Sbjct: 903 TLAAQITAVNDIAEQLLKANPPGKDRIVN--TQEQLNHRWQQFRRLADGKKAALTSALS- 959
Query: 2681 RCDWIDQAIVKSTQYQSLLRSLS---DKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMK 2737
I ++ T+ Q+ +R + + L N L+ LA+ + LE
Sbjct: 960 ----IQNYHLECTETQAWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARV 1015
Query: 2738 QEIQQEKKQIKV---AQALCEDLSALVKE-----EYLKAELSRQLEGILKSFKDVEQKAE 2789
E+ +E + AQA+ ++A ++E E L+A + R+ E +
Sbjct: 1016 GELTREANALAAGHPAQAVA--INARLREVQTGWEDLRATMRRREESL------------ 1061
Query: 2790 NHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKT 2849
+ LQ F + DFQAWL + + S A L E+L+ H
Sbjct: 1062 GEARRLQD-------FLRSLDDFQAWLG-RTQTAVASEEGPATLPEAEALLAQHAALRGE 1113
Query: 2850 LTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKES-- 2907
+ Y + A GE + + L+ +L + T W+ + + R+ +L ++
Sbjct: 1114 VERAQSEYSRLRALGEEVTRDQADPQCLFLRQRLEALGTGWEELGRMWESRQGRLAQAHG 1173
Query: 2908 LEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVEL 2967
+ L+ Q E + L ++ L E ++ + K+++ ++
Sbjct: 1174 FQGFLRDARQAEGV----------LSSQEYVLSHTEMPGTLQAADAAIKKLEDFMSTMDA 1223
Query: 2968 LNNTANSLLSVCEIDKEVVTDEN---KSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEV 3024
+ LL E +++V++ N + +K D + E+ H K ++ Q+F
Sbjct: 1224 NGERIHGLL---EAGRQLVSEGNIHADKIREKADSI-ERRHKKN---QDAAQQFLGRLRD 1276
Query: 3025 SKESKRQLQ-CAKEQLDIHDS-LGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDL 3082
++E + LQ C + +L I + L +Q S L T+ + KHQ +A+ A
Sbjct: 1277 NREQQHFLQDCHELKLWIDEKMLTAQDVSYDEARNLHTKWQ-----KHQAFMAELAANKD 1331
Query: 3083 VVEASDSKGTSDVLLQVE---TIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFS 3139
++ D +G L + E ++++ L ++ DE LET Q R +F
Sbjct: 1332 WLDKVDKEGRELTLEKPELKALVSEKLRDLHRRWDE----LETTTQA------KARSLFD 1381
Query: 3140 QFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETS 3199
AE + ++++L+ L+A + S+D + + ++
Sbjct: 1382 ---------------ANRAELFAQSCCALESWLESLQAQLHSDDYGKDLTSVNILLKKQQ 1426
Query: 3200 P---DLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKL----KEFSILLQ 3252
++ ++++EA+ Q L Q E VE T + +EE + L +E LQ
Sbjct: 1427 MLEWEMAVREKEVEAIQAQAKALAQEDQGAGE-VERTSRAVEEKFRALCQPMRERCRRLQ 1485
Query: 3253 KAEEHEESQGPVGMETETINQQLNMFKVFQK----EEIEPLQGKQQDVNWLGQGL----- 3303
+ E + V E + ++L M + ++ L K Q + QG
Sbjct: 1486 ASREQHQFHRDVEDEILWVTERLPMASSMEHGKDLPSVQLLMKKNQTLQKEIQGHEPRIA 1545
Query: 3304 -IQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWM 3362
++ ++ +L ++ WK L ++ R +L++AL ++DA E+ +WM
Sbjct: 1546 DLRERQRALGAAAAGPELAELQEMWKRLGHELELRGKRLEDALRAQQFYRDAAEA-EAWM 1604
Query: 3363 VDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADK 3422
+ E + Q+ E +A++++ ++L++ L D T+ + + + P +
Sbjct: 1605 GEQELHMMGQEKAKDELS-AQAEVKKHQVLEQALADYAQTIHQLAASSQDMIDHEHP-ES 1662
Query: 3423 VKILKQLSLLDSRWEALLNKA-ETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLV-- 3479
+I + + +D + L A E R R E + + Q L+ L +W+ E+ +V
Sbjct: 1663 TRISIRQAQVDKLYAGLKELAGERRERLQEHLRLC--QLRRELDDLEQWIQ--EREVVAA 1718
Query: 3480 ------NCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDM 3533
+ E + K E + + ++ L + G + E KD
Sbjct: 1719 SHELGQDYEHVTMLRDKFREFSRDTSTIGQERVDSANALANGLIAGGHAARATVAEWKD- 1777
Query: 3534 VQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLS-V 3592
++ W ++ E +R ++L A EL +L+ L+++
Sbjct: 1778 -----SLNEAW-ADLLELLDTRGQVLAAA-----------YELQRFLHGARQALARVQHK 1820
Query: 3593 QDYSTEGLWKQQSELRVLQ-------EDILLRKQNVDQALLNGLELLKQTTGDEVLIIQD 3645
Q +G + + LQ DI V Q +G L K GD+ I
Sbjct: 1821 QQQLPDGTGRDLNAAEALQRRHCAYEHDIQALSPQVQQVQDDGHRLQKAYAGDKAEEIGR 1880
Query: 3646 KLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLK 3705
++A+ + + S + L R + EL W+D+V +++ + E +
Sbjct: 1881 HMQAVAEAWAQLQGSSAARRQLLLDTTDKFRFFKAV-RELMLWMDEVNLQMDAQE----R 1935
Query: 3706 GEEASQAQMRPKE---LKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNER 3762
+ S A + K +K E + S ++ LL + A E EK+ R
Sbjct: 1936 PRDVSSADLVIKNQQGIKAEIEARADRFSSCIDMGKELLARSHYAAEEISEKLSQLQARR 1995
Query: 3763 YRLVSDTITQKVEEID--AAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSA 3820
+T + E++D +L F + A +W+ +++ L+ ++ D+ +
Sbjct: 1996 ----QETAEKWQEKMDWLQLVLEVLVFGRDAGMAEAWLC-SQEPLVRSAELGCTVDEVES 2050
Query: 3821 QLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKK 3864
++ + F + ++ L K +TA E EK+ +K+
Sbjct: 2051 LIKRHEAFQKSAVAWEERFCALEK-----LTALEEREKERKRKR 2089
Score = 108 bits (269), Expect = 2e-22
Identities = 343/1970 (17%), Positives = 756/1970 (38%), Gaps = 251/1970 (12%)
Query: 1466 KRLEEEEKSLEE-EKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTK 1524
K L+ E+ ++++ ++K + + S + + ++ GK + +E + K
Sbjct: 252 KLLDPEDVNVDQPDEKSIITYVATYYHYFSKMKALAVEGKRIGK--VLDHAMEAERLVEK 309
Query: 1525 KEQL-SEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSG 1583
E L SE LQ I+ + D+ + ++ Q+++ SY ++++ + G
Sbjct: 310 YESLASELLQWIEQTIVTLNDRQLANSLSGVQNQLQSFN-SYR-----TVEKPPKFTEKG 363
Query: 1584 DVKV-----EEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQS 1638
+++V + K+ A Q+ Y T E RLI I L+K +
Sbjct: 364 NLEVLLFTIQSKLRANNQKVY-----------TPREGRLISD-----INKAWERLEKAEH 407
Query: 1639 KQE-----EL--QKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKC 1691
++E EL Q+ ++ A E +L EN +SQ++ L + A K
Sbjct: 408 ERELALRTELIRQEKLEQLAARFDRKAAMRETWLSENQRLVSQDNFGLELAAVEAAVRKH 467
Query: 1692 EQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAG 1751
E + + V A + E+ +K++ + + L D+L +
Sbjct: 468 EAIETDIVAYSGRVQAVDAVAAELAAERYHDIKRIAARQHNVARLWDFL------RQMVA 521
Query: 1752 TKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQH 1811
+ ++++ D + +E+ G L D+ G+ E+L Q ++ V+A
Sbjct: 522 ARRERLLLNLELQKVFQDLLYLMDWMEEMKGRLQSQDL-GRHLAGVEDLLQLHELVEAD- 579
Query: 1812 EKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKL 1871
I+ + A ++ + G+ P + + + + + +L+ YE AL E +
Sbjct: 580 ---IAVQAERVRAVSASALRFCNPGKEYRPCDPQLVSERVAKLEQSYE-ALCELAAARRA 635
Query: 1872 THSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHK 1931
L +F + E E W+++ + L + + G D+ G + L + + ++
Sbjct: 636 RLEESRRLWRFLWEVGEAEAWVREQQHLLASADTGR-DLTGALRLLNKHTALRGEMSGRL 694
Query: 1932 GDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGN 1991
G L+ G +++ ++ G SA E+Q ++ L +
Sbjct: 695 GPLKLTLEQGQQLV------AEGHPGASQASARAAELQA-------QWERLEALAEERAQ 741
Query: 1992 NLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEP-IAVDPKNLQRQLEETKALQGQI 2050
L YQ DA+ ++A A + +S P + D + Q + +AL+ +I
Sbjct: 742 RLAQAASLYQFQADAN-----DMEAWLVDALRLVSSPELGHDEFSTQALARQHRALEEEI 796
Query: 2051 SSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITL 2110
S + ++ L++ A L L ++Q + + YE+L ER L+ L
Sbjct: 797 RSHRPTLDALREQAAAL----PPTLSRTPEVQGRVPTLERHYEELQARAGERARALEAAL 852
Query: 2111 TRSLSVQDG------LDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGR 2164
+ + ++E W+ + +P L+ + + LE ++
Sbjct: 853 ALYTMLSEAGACGLWVEEKEQWLNGL--------ALPERLEDLEVVQQRFETLEPEMNTL 904
Query: 2165 QSSINAMNEKVKKFMETTDP--STASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKV 2222
+ I A+N+ ++ ++ P + Q ++ +F + K L +
Sbjct: 905 AAQITAVNDIAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALTS----ALSI 960
Query: 2223 ELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLK 2282
+ + + Q ++ KT+ + G D+ + ++ ++ LE + + +
Sbjct: 961 QNYHLECTETQAWMREKTKVIESTQGLGNDLAGVLALQRKLAGT----ERDLEAIAARVG 1016
Query: 2283 EIS------SHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVK 2336
E++ + G P+ + + + ++++ T++ ++E++ + +L F +
Sbjct: 1017 ELTREANALAAGHPAQAVAINARLREVQTGWEDLRATMRRREESLGEAR-RLQDFLRSLD 1075
Query: 2337 SLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLI 2396
++W+ T Q + +E+ +L + + L + + E+++ + L L
Sbjct: 1076 DFQAWLGRT-------QTAVASEEGPATLPEAEALLAQHAALRGEVERAQSEYSRLRALG 1128
Query: 2397 SAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLK 2456
VT A+ +++ + + G+E+LG + +
Sbjct: 1129 EEVTRDQ--------------------------ADPQCLFLRQRLEALGTGWEELGRMWE 1162
Query: 2457 D---KIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNK 2513
++A+ + L+ A++ + ++ T P +A +++ +
Sbjct: 1163 SRQGRLAQAHGFQGFLRDARQAEGVLSSQEYVLS-------HTEMPGTLQAADAAIKKLE 1215
Query: 2514 SFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWK-QMLTEIDSKWQELNQLTIDRQQ 2572
F + + N ++ L + +L+ E + R K + K Q+ Q + R +
Sbjct: 1216 DFMSTMDANGERIHGLLEAGRQLVSEGNIHADKIREKADSIERRHKKNQDAAQQFLGRLR 1275
Query: 2573 KLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATR 2632
E + L +LK W+ EK M++ + L+T+ Q+ Q + E A
Sbjct: 1276 DNREQQHFLQDCH----ELKLWIDEK--MLTAQDVSYDEARNLHTKWQKHQAFMAELAAN 1329
Query: 2633 KPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKS 2692
K +++ G+ + E P L+ +V E+L + ++WD L + QA +S
Sbjct: 1330 KDWLDKVDKEGRELTL---EKPELKALVSEKLRDLHRRWDEL--------ETTTQAKARS 1378
Query: 2693 TQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPD-------AMNQQLETAQKMKQEIQQEKK 2745
+ + L++ L SL H D ++N L+ Q ++ E+ +K
Sbjct: 1379 LFDANRAELFAQSCCALESWL-ESLQAQLHSDDYGKDLTSVNILLKKQQMLEWEMAVREK 1437
Query: 2746 QIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQF 2805
+++ QA AL +E+ E+ R + + F+ + Q + LQ A HQF
Sbjct: 1438 EVEAIQA---QAKALAQEDQGAGEVERTSRAVEEKFRALCQPMRERCRRLQ-ASREQHQF 1493
Query: 2806 QQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGE 2865
+ D W+ T++ S L ++ L+K ++ K + Q H E IA+
Sbjct: 1494 HRDVEDEILWV-TERLPMASSMEHGKDLPSVQLLMKKNQTLQKEI--QGH--EPRIAD-- 1546
Query: 2866 NLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWI 2925
L + + AA +L ++ W +++ R +L+++L Y++ E W+
Sbjct: 1547 -LRERQRALGAAAAGPELAELQEMWKRLGHELELRGKRLEDALRAQQFYRDAAEA-EAWM 1604
Query: 2926 DKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEV 2985
+ + ++ G+ S Q E+ +H + + L + A ++ + +++
Sbjct: 1605 GEQELHM----------MGQEKAKDELSAQAEVKKHQVLEQALADYAQTIHQLAASSQDM 1654
Query: 2986 VTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSL 3045
+ E+ + + Q K + + E +E +E R Q +E D+ +
Sbjct: 1655 IDHEHP---ESTRISIRQAQVDKL-YAGLKELAGERRERLQEHLRLCQLRRELDDLEQWI 1710
Query: 3046 GSQ---------AYSNKYLTMLQTQQKSLQ-----ALKHQVDLAKRLAQDLVVEASDSKG 3091
+ +++TML+ + + + +VD A LA L+ ++
Sbjct: 1711 QEREVVAASHELGQDYEHVTMLRDKFREFSRDTSTIGQERVDSANALANGLIAGGHAARA 1770
Query: 3092 TSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSM 3151
T V +++ + + L + +D + L + + F + R+ ++ +L
Sbjct: 1771 T--VAEWKDSLNEAWADLLELLDTRGQVLAAAYE-LQRFLHGARQALARVQHKQQQLPD- 1826
Query: 3152 APVGRD---AETLQKQ----KETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVG 3204
GRD AE LQ++ + I+A +++ + K A E
Sbjct: 1827 -GTGRDLNAAEALQRRHCAYEHDIQALSPQVQQVQDDGHRLQKAYAGDKAEE-------- 1877
Query: 3205 IKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAE---EHEESQ 3261
I R ++A+++ +L + AR + + T + F+ ++E + + + + +E
Sbjct: 1878 IGRHMQAVAEAWAQLQGSSAARRQLLLDTTDKF-RFFKAVRELMLWMDEVNLQMDAQERP 1936
Query: 3262 GPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLD 3321
V I Q + K EIE + +G+ L+ A + + + L
Sbjct: 1937 RDVSSADLVIKNQQGI-----KAEIEARADRFSSCIDMGKELL--ARSHYAAEEISEKLS 1989
Query: 3322 DVNARWKTLNKKVAQRAAQLQEAL--LHCGRFQDALESLLSWMVDTEELV 3369
+ AR + +K ++ LQ L L GR E +W+ E LV
Sbjct: 1990 QLQARRQETAEKWQEKMDWLQLVLEVLVFGRDAGMAE---AWLCSQEPLV 2036
Score = 106 bits (264), Expect = 7e-22
Identities = 329/1810 (18%), Positives = 700/1810 (38%), Gaps = 208/1810 (11%)
Query: 2883 LNTIKTNWDTFNKQVKERENKLK------ESLEK-ALKYKEQVETLWPWIDKCQNNLEEI 2935
++ I W+ K ERE L+ E LE+ A ++ + W+ + Q + +
Sbjct: 392 ISDINKAWERLEKAEHERELALRTELIRQEKLEQLAARFDRKAAMRETWLSENQRLVSQD 451
Query: 2936 KFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQ 2995
F L+ A E ++ K ++++ ++ + G V+ ++ A L + D + + ++ +
Sbjct: 452 NFGLELAAVEAAVRKHEAIETDIVAYSGRVQAVDAVAAELAAERYHDIKRIAARQHNVAR 511
Query: 2996 KVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYL 3055
D + + + +++ L + K FQ D L + +
Sbjct: 512 LWDFLRQMVAARRERLLLNLELQKVFQ--------------------DLLYLMDWMEEMK 551
Query: 3056 TMLQTQQ--KSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQ- 3112
LQ+Q + L ++ + L + + D+ V+A + S L+ +E+ Q
Sbjct: 552 GRLQSQDLGRHLAGVEDLLQLHELVEADIAVQAERVRAVSASALRFCNPGKEYRPCDPQL 611
Query: 3113 VDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFL 3172
V E+ + LE + + R + R + +A++
Sbjct: 612 VSERVAKLEQSYEALCELAAARRARLEE--------------SRRLWRFLWEVGEAEAWV 657
Query: 3173 KKLEALMASNDNANK-TCKMMLATEETS--PDLVGIKRDLEALSKQCNKLL-------DR 3222
++ + L+AS D T + L + T+ ++ G L+ +Q +L+ +
Sbjct: 658 REQQHLLASADTGRDLTGALRLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEGHPGASQ 717
Query: 3223 AQAREEQVEGTIKRLE----EFYSKLKEFSILLQKAEEHEESQG-----------PVGME 3267
A AR +++ +RLE E +L + + L Q + + + P
Sbjct: 718 ASARAAELQAQWERLEALAEERAQRLAQAASLYQFQADANDMEAWLVDALRLVSSPELGH 777
Query: 3268 TETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARW 3327
E Q L +EEI + + L + +++ QG L+ +
Sbjct: 778 DEFSTQALARQHRALEEEIRSHRPTLDALREQAAALPPTLSRTPEVQGRVPTLE---RHY 834
Query: 3328 KTLNKKVAQRAAQLQEALLHCGRFQDALESLLS-------WMVDTEELVANQKPPSA--E 3378
+ L + +RA L+ AL AL ++LS W+ + E+ + P +
Sbjct: 835 EELQARAGERARALEAAL--------ALYTMLSEAGACGLWVEEKEQWLNGLALPERLED 886
Query: 3379 FKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEA 3438
+VV+ Q + L+ ++ + + + E++ A P K +I+ L+ RW+
Sbjct: 887 LEVVQ---QRFETLEPEMNTLAAQITAVNDIAEQLLK-ANPPGKDRIVNTQEQLNHRWQQ 942
Query: 3439 LLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQH 3498
A+ + L ++ Q +H W+ K + + + +G + + +
Sbjct: 943 FRRLADGKKAALTS-ALSIQNYHLECTETQAWMREKTKVIESTQGLGNDLAGVLALQRKL 1001
Query: 3499 KALEDDI------INHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKS 3552
E D+ + A++ G + ++ + ++L Q + +++
Sbjct: 1002 AGTERDLEAIAARVGELTREANALAAGHPAQAVA-------INARLREVQTGWEDLRATM 1054
Query: 3553 HSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYST----EGLWKQQSELR 3608
R E L +A + F + WL ++ S + +T E L Q + LR
Sbjct: 1055 RRREESLGEAR-RLQDFLRSLDDFQAWLGRTQTAVA--SEEGPATLPEAEALLAQHAALR 1111
Query: 3609 VLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTL 3668
++ + + G E+ + + L ++ +LEA+ ++++ ++ L
Sbjct: 1112 ---GEVERAQSEYSRLRALGEEVTRDQADPQCLFLRQRLEALGTGWEELGRMWESRQGRL 1168
Query: 3669 EQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKA 3728
QA L + +LS + VL E K+ ++ +
Sbjct: 1169 AQAHGFQGFLRDARQA---------EGVLSSQEYVLSHTEMPGTLQAADAAIKKLEDFMS 1219
Query: 3729 LLDSLNEVSSALLELVPWRAREGLEKMVAEDN---ERYRLVSDTITQKVEEIDAAILR-- 3783
+D+ E LLE ++V+E N ++ R +D+I ++ ++ A +
Sbjct: 1220 TMDANGERIHGLLEAG--------RQLVSEGNIHADKIREKADSIERRHKKNQDAAQQFL 1271
Query: 3784 --------SQQFDQAADAELSWITETEKKLMSLGDIRLEQDQT-SAQLQVQKTFTMEILR 3834
Q F Q WI E K+++ D+ ++ + + Q + F E+
Sbjct: 1272 GRLRDNREQQHFLQDCHELKLWIDE---KMLTAQDVSYDEARNLHTKWQKHQAFMAELAA 1328
Query: 3835 HKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYD---TICQINSERYLQLERAQS 3891
+KD +D + K G ++ T E K + +KL + + +D T Q + RA+
Sbjct: 1329 NKDWLDKVDKEGREL-TLEKPELKALVSEKLRDLHRRWDELETTTQAKARSLFDANRAEL 1387
Query: 3892 LVNQFWETYEELWPWLTETQSIISQLPAP--ALEYETLRQQQEEHRQLRELIAEHKPHID 3949
F ++ L WL +S+ +QL + + ++ ++ + L +A + ++
Sbjct: 1388 ----FAQSCCALESWL---ESLQAQLHSDDYGKDLTSVNILLKKQQMLEWEMAVREKEVE 1440
Query: 3950 KMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFH-DKI 4008
+ L + G G ++ A + + + + +++R L +A + QFH D
Sbjct: 1441 AIQAQAKALAQEDQGAG-EVERTSRAVEEKFRALCQPMRERCRRL-QASREQHQFHRDVE 1498
Query: 4009 DQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIA 4068
D+IL ER+ P + S E K + +V + M+K Q L + + Q E IA
Sbjct: 1499 DEILWVTERL------PMASSMEHGK------DLPSVQLLMKKNQTLQKEI-QGHEPRIA 1545
Query: 4069 RSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTI 4128
+ + A A +L ++ +W+ + +E R +L D + A++F+ D +
Sbjct: 1546 DLRERQRALGAAAAGPELAELQEMWKRLGHELELRGKRLEDALR-AQQFYRDAAEAEAWM 1604
Query: 4129 KDTQDFIRDLEDPGIDPSV---VKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGE 4185
+ + + E + S VK+ Q + + + + + + S+ +
Sbjct: 1605 GEQELHMMGQEKAKDELSAQAEVKKHQVLEQALADYAQTIHQ-----LAASSQDMIDHEH 1659
Query: 4186 PDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLA 4245
P+ + +++ + L + +R ++L+E ++ Q + L + W+ +A
Sbjct: 1660 PESTRISIRQAQVDKLYAGLKELAGERRERLQEHLRLC-QLRRELDDLEQWIQ-EREVVA 1717
Query: 4246 SMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTE-ESDKHTVQDP 4304
+ +G D E V ++ ++F + I ER++ L + + + TV +
Sbjct: 1718 ASHELGQDYEHVTMLRDKFREFSRDT--STIGQERVDSANALANGLIAGGHAARATVAEW 1775
Query: 4305 LMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDP 4364
L W L E + R L A L +F H + LA + H + L + G D
Sbjct: 1776 KDSLNEAWADLLELLDTRGQVLAAAY-ELQRFLHGARQALARVQHKQQQLPDG--TGRDL 1832
Query: 4365 KAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNV 4424
A E +H ++D+ A V+ V G+ L ++ AG++A + ++ + + W +
Sbjct: 1833 NAAEALQRRHCAYEHDIQALSPQVQQVQDDGHRLQKAYAGDKAEEIGRHMQAVAEAWAQL 1892
Query: 4425 LEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLAS---KPLGGLPETAKEQLN 4481
+ R+Q L + + F + +L W+ + + A + + K Q
Sbjct: 1893 QGSSAARRQLLLDTTDKFRFFKA-VRELMLWMDEVNLQMDAQERPRDVSSADLVIKNQQG 1951
Query: 4482 VHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERK 4541
+ E+ EA+ + + S + G+++LAR +AE I + ++ L+ + + K E+
Sbjct: 1952 IKAEI----EARADRFSSCIDMGKELLARSHYAAE-EISEKLSQLQARRQETAEKWQEKM 2006
Query: 4542 TKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNS 4601
L+ L + + F WL E + A +D V I H+ F +
Sbjct: 2007 DWLQLVLEV-LVFGRDAGMAEAWLCSQEPLVRSAEL-GCTVDEVESLIKRHEAFQKSAVA 2064
Query: 4602 HREQIIELDK 4611
E+ L+K
Sbjct: 2065 WEERFCALEK 2074
Score = 68.9 bits (167), Expect = 1e-10
Identities = 63/282 (22%), Positives = 116/282 (41%), Gaps = 16/282 (5%)
Query: 646 KFVQDLL---NWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISE 702
K QDLL +W++EM+ +L + G L VE L+ H+ V I ++ S
Sbjct: 535 KVFQDLLYLMDWMEEMKGRLQSQDLGRHLAGVEDLLQLHELVEADIAVQAERVRAVSASA 594
Query: 703 IQMTAPLK-------LTYAEKLHRLESQYAKLLNTSRNQERHLDT---LHNFVSRATNEL 752
++ P K +E++ +LE Y L + + L+ L F+
Sbjct: 595 LRFCNPGKEYRPCDPQLVSERVAKLEQSYEALCELAAARRARLEESRRLWRFLWEVGEAE 654
Query: 753 IWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPA 812
W+ E++ + D T R + H L E+ + +K E +QL+ E HP
Sbjct: 655 AWVREQQHLLASADTGRDLTGALRLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEGHPG 714
Query: 813 RLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKY 872
A A +Q QW + L + Q + + + ++F DA + + L DA++
Sbjct: 715 ASQASARAAELQAQWERLEALAEERAQRLAQAASLYQFQADANDMEAW---LVDALRLVS 771
Query: 873 SCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTI 914
S + + L ++ +EE+ ++ T+ L +A +
Sbjct: 772 SPELGHDEFSTQALARQHRALEEEIRSHRPTLDALREQAAAL 813
Score = 51.2 bits (121), Expect = 3e-05
Identities = 48/266 (18%), Positives = 109/266 (40%), Gaps = 24/266 (9%)
Query: 654 WVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTA---PLK 710
W+ E ++ + E D S ++ ++ H+ + +A+ ++ ++ + S M P
Sbjct: 1603 WMGEQELHMMGQEKAKDELSAQAEVKKHQVLEQALADYAQTIHQLAASSQDMIDHEHPES 1662
Query: 711 LTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELI----WLNEKEEEEVAYD 766
+ + +++ YA L + + L H + + EL W+ E+E +++
Sbjct: 1663 TRISIRQAQVDKLYAGLKELAGERRERLQE-HLRLCQLRRELDDLEQWIQEREVVAASHE 1721
Query: 767 WSERNTNIARKKDYHAELMRELDQ-KEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQT 825
+ ++ +D E R+ +E + S +A L+ H AR T+ ++ ++
Sbjct: 1722 LGQDYEHVTMLRDKFREFSRDTSTIGQERVDSANALANGLIAGGHAARATVAEWKDSLNE 1781
Query: 826 QWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLR--------------NLKDAIQRK 871
W+ +L+L Q + F + A++A ++ N +A+QR+
Sbjct: 1782 AWADLLELLDTRGQVLAAAYELQRFLHGARQALARVQHKQQQLPDGTGRDLNAAEALQRR 1841
Query: 872 YSCDRSSSIHKLEDLVQESMEEKEEL 897
+ C I L VQ+ ++ L
Sbjct: 1842 H-CAYEHDIQALSPQVQQVQDDGHRL 1866
Score = 45.8 bits (107), Expect = 0.001
Identities = 52/280 (18%), Positives = 110/280 (39%), Gaps = 28/280 (10%)
Query: 633 LLDQNLTEEEINMKF---VQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIE 689
+LD + E + K+ +LL W+++ V L+ + + L V++ L++ N +R +E
Sbjct: 296 VLDHAMEAERLVEKYESLASELLQWIEQTIVTLNDRQLANSLSGVQNQLQSF-NSYRTVE 354
Query: 690 EFESSLKEAKISEIQMTAPLKL------TYA--------------EKLHRLESQYAKLLN 729
+ ++ + + T KL Y E+L + E + L
Sbjct: 355 KPPKFTEKGNLEVLLFTIQSKLRANNQKVYTPREGRLISDINKAWERLEKAEHERELALR 414
Query: 730 TSRNQERHLDTLH-NFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMREL 788
T ++ L+ L F +A WL+E + ++ + H + ++
Sbjct: 415 TELIRQEKLEQLAARFDRKAAMRETWLSENQRLVSQDNFGLELAAVEAAVRKHEAIETDI 474
Query: 789 DQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYF 848
+++V +A +L E + I A + + W ++ Q+ + + N
Sbjct: 475 VAYSGRVQAVDAVAAELAAERYHDIKRIAARQHNVARLWDFLRQMVAARRERLLLNLELQ 534
Query: 849 EFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQ 888
+ F D D++ +K +Q S D + +EDL+Q
Sbjct: 535 KVFQDLLYLMDWMEEMKGRLQ---SQDLGRHLAGVEDLLQ 571
Score = 45.8 bits (107), Expect = 0.001
Identities = 205/1138 (18%), Positives = 417/1138 (36%), Gaps = 193/1138 (16%)
Query: 1153 KKELERLKDDLGTITNKCEEFFSQAAASSSVPTLR-SELNVVLQNMNQVYSMSSTYIDKL 1211
+++LE + +G +T + + A + R E+ +++ + +
Sbjct: 1005 ERDLEAIAARVGELTREANALAAGHPAQAVAINARLREVQTGWEDLRATMRRREESLGEA 1064
Query: 1212 KTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVF-- 1269
+ + L++ +A + +T + EE A E L++ R EV+ + +
Sbjct: 1065 RRLQDFLRSLDDFQAWLGRTQTAVASEEGP-ATLPEAEALLAQHAALRGEVERAQSEYSR 1123
Query: 1270 -HALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNR------- 1321
AL +E+ + +A +F + L W ++L W++ ++
Sbjct: 1124 LRALGEEVTRDQADPQCLFLRQRLEALGTGW-----EELGRMWESRQGRLAQAHGFQGFL 1178
Query: 1322 --LRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQE---NQPENSKTLATQLNQQKM 1376
R EG+ S +Y ++ + +Q + +K+++ N + + L +
Sbjct: 1179 RDARQAEGVLSSQEYVL-SHTEMPGTLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQ 1237
Query: 1377 LVSEIEMKQSKMDEC-----------QKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVK 1425
LVSE + K+ E Q A+Q+ ++D Q + D +
Sbjct: 1238 LVSEGNIHADKIREKADSIERRHKKNQDAAQQFLGRLRDNREQQ---HFLQDCHELKLWI 1294
Query: 1426 RRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHV-- 1483
+M ++ D+ E +L T++ M + + D L ++++E + L EK E
Sbjct: 1295 DEKMLTAQDVSYDEARNLHTKWQKHQAFMAE-LAANKDWLDKVDKEGRELTLEKPELKAL 1353
Query: 1484 --EKAKELQKWVSNISKT-------LKDAEKAGKPPFS----KQKISSEEISTKKEQLSE 1530
EK ++L + + T L DA +A S + + S + + +
Sbjct: 1354 VSEKLRDLHRRWDELETTTQAKARSLFDANRAELFAQSCCALESWLESLQAQLHSDDYGK 1413
Query: 1531 ALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEK 1590
L ++ + L K +M + E EK+V+ +Q L QE Q +G+V+ +
Sbjct: 1414 DLTSVNILLKKQ--QMLEWEMAVREKEVEAIQAQAKAL-------AQEDQGAGEVERTSR 1464
Query: 1591 IVAERQQEYKEKLQGICDLLTQTENRLIGHQE----------------AFMIGDGTVELK 1634
V E+ + + ++ C L + + H++ + G ++
Sbjct: 1465 AVEEKFRALCQPMRERCRRLQASREQHQFHRDVEDEILWVTERLPMASSMEHGKDLPSVQ 1524
Query: 1635 KYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQL 1694
K + LQK++QG +A+ L+E L A +L E + ++L
Sbjct: 1525 LLMKKNQTLQKEIQGHEPRIAD--------LRERQRALG---AAAAGPELAELQEMWKRL 1573
Query: 1695 NLKAEQSKKELDKVVTTA--IKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGT 1752
+ E K L+ + ++ E A + + E E D L S +A
Sbjct: 1574 GHELELRGKRLEDALRAQQFYRDAAEAEAWMGEQELHMMGQEKAKDEL------SAQAEV 1627
Query: 1753 KHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHE 1812
K QV+EQ + + + A +D ++ E+ ++ Q +++ Y +K
Sbjct: 1628 KKHQVLEQALADYAQTIHQLAASSQDMIDHEHPEST---RISIRQAQVDKLYAGLKE--- 1681
Query: 1813 KIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLT 1872
L+ E +E+LQ++++ +
Sbjct: 1682 --------------------------LAGERRERLQEHLRLCQ----------------- 1698
Query: 1873 HSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKG 1932
L+ EL+ + E W+Q+ E + E G D + M + + + FS D
Sbjct: 1699 --LRRELD-------DLEQWIQEREVVAASHELGQDYEHVTMLR-DKFREFSRDT----- 1743
Query: 1933 DLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHA-TDRFRSLYSKCNVLGN 1991
TI RV A + G AT E + L+ A D L ++ VL
Sbjct: 1744 ----STIGQERVDSANALANGLIAGGHAARATVAEWKDSLNEAWADLLELLDTRGQVLA- 1798
Query: 1992 NLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQIS 2051
+ Q + + LA +Q H + + P R L +ALQ +
Sbjct: 1799 ----AAYELQRFLHGARQALARVQ--------HKQQQL---PDGTGRDLNAAEALQRRHC 1843
Query: 2052 SQQVAVEKLKKTAEVLLDARGSLLPA-----KNDIQKTLDDIVGRYEDLSKSVNERNEKL 2106
+ + ++ L + + D L A +I + + + + L S R + L
Sbjct: 1844 AYEHDIQALSPQVQQVQDDGHRLQKAYAGDKAEEIGRHMQAVAEAWAQLQGSSAARRQ-L 1902
Query: 2107 QITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQS 2166
+ T + E++ WM V + Q + P + ++ +I ++ +I R
Sbjct: 1903 LLDTTDKFRFFKAVRELMLWMDEVNLQMDAQ-ERPRDVSSADLVIKNQQGIKAEIEARAD 1961
Query: 2167 SINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVEL 2224
++ + K+ + + A + K+ L AR E + K +E KM+ L+ +E+
Sbjct: 1962 RFSSCIDMGKELLARSH-YAAEEISEKLSQLQARRQETAEKWQE---KMDWLQLVLEV 2015
Score = 43.1 bits (100), Expect = 0.008
Identities = 62/299 (20%), Positives = 118/299 (39%), Gaps = 36/299 (12%)
Query: 632 SLLDQNLTEEEINMKFVQD---LLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAI 688
SL D N E F Q L +W++ +Q QL ++G DL SV L+ + +
Sbjct: 1378 SLFDANRAE-----LFAQSCCALESWLESLQAQLHSDDYGKDLTSVNILLKKQQML---- 1428
Query: 689 EEFESSLKEAKISEIQMTAPLKLT------YAEKLHR-LESQYAKLLNTSRNQERHLDT- 740
E+E +++E ++ IQ A E+ R +E ++ L R + R L
Sbjct: 1429 -EWEMAVREKEVEAIQAQAKALAQEDQGAGEVERTSRAVEEKFRALCQPMRERCRRLQAS 1487
Query: 741 --LHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSV 798
H F +E++W+ E+ + + + ++ + L +E+ E I +
Sbjct: 1488 REQHQFHRDVEDEILWVTERLPMASSMEHGKDLPSVQLLMKKNQTLQKEIQGHEPRIADL 1547
Query: 799 QEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEAT 858
+E L L A +Q W + + + +++ +F+ DA EA
Sbjct: 1548 RERQRALGAAAAGPEL------AELQEMWKRLGHELELRGKRLEDALRAQQFYRDAAEAE 1601
Query: 859 DYL--RNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTII 915
++ + L Q K + S+ V++ ++ L Y TI L ++ +I
Sbjct: 1602 AWMGEQELHMMGQEKAKDELSAQAE-----VKKHQVLEQALADYAQTIHQLAASSQDMI 1655
Score = 40.8 bits (94), Expect = 0.038
Identities = 37/205 (18%), Positives = 84/205 (40%), Gaps = 16/205 (7%)
Query: 648 VQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQM-- 705
V+D + WV E E G DLPSV+ ++ ++ + + I+ E + + + + +
Sbjct: 1497 VEDEILWVTERLPMASSMEHGKDLPSVQLLMKKNQTLQKEIQGHEPRIADLRERQRALGA 1556
Query: 706 ------TAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKE 759
A L+ + H LE + +L + R Q+ + D A W+ E+E
Sbjct: 1557 AAAGPELAELQEMWKRLGHELELRGKRLEDALRAQQFYRD--------AAEAEAWMGEQE 1608
Query: 760 EEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAY 819
+ + ++ + + H L + L + I + ++ ++ HP I
Sbjct: 1609 LHMMGQEKAKDELSAQAEVKKHQVLEQALADYAQTIHQLAASSQDMIDHEHPESTRISIR 1668
Query: 820 RAAMQTQWSWILQLCQCVEQHIKEN 844
+A + ++ + +L + ++E+
Sbjct: 1669 QAQVDKLYAGLKELAGERRERLQEH 1693
Score = 40.4 bits (93), Expect = 0.049
Identities = 44/225 (19%), Positives = 86/225 (38%), Gaps = 5/225 (2%)
Query: 650 DLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPL 709
D+ W+ + + E G D S ++ H+ + I +L + + L
Sbjct: 758 DMEAWLVDALRLVSSPELGHDEFSTQALARQHRALEEEIRSHRPTLDALREQAAALPPTL 817
Query: 710 KLT--YAEKLHRLESQYAKLLNTSRNQERHLDT---LHNFVSRATNELIWLNEKEEEEVA 764
T ++ LE Y +L + + R L+ L+ +S A +W+ EKE+
Sbjct: 818 SRTPEVQGRVPTLERHYEELQARAGERARALEAALALYTMLSEAGACGLWVEEKEQWLNG 877
Query: 765 YDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQ 824
ER ++ + L E++ I +V +IAEQLL N P + I + +
Sbjct: 878 LALPERLEDLEVVQQRFETLEPEMNTLAAQITAVNDIAEQLLKANPPGKDRIVNTQEQLN 937
Query: 825 TQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQ 869
+W +L + + + + + E ++R I+
Sbjct: 938 HRWQQFRRLADGKKAALTSALSIQNYHLECTETQAWMREKTKVIE 982
Score = 38.5 bits (88), Expect = 0.19
Identities = 59/307 (19%), Positives = 124/307 (40%), Gaps = 44/307 (14%)
Query: 1304 ADQLVERWQNVHVQI-DNRLRDL---EGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQEN 1359
A Q + R Q+ Q+ D RDL E + + Y L +QQV+ ++Q+
Sbjct: 1810 ARQALARVQHKQQQLPDGTGRDLNAAEALQRRHCAYEHDIQALSPQVQQVQDDGHRLQKA 1869
Query: 1360 QPENSKTLATQLNQQKMLVSEI---------EMKQSKMDECQKYAEQYSATVKDYELQTM 1410
+ A ++ + V+E +Q +D K+ ++ V++ L
Sbjct: 1870 YAGDK---AEEIGRHMQAVAEAWAQLQGSSAARRQLLLDTTDKF--RFFKAVRELMLWMD 1924
Query: 1411 TYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRT-------RYTALVTLMTQYIKFAGD 1463
+D+Q+ R R SSADL+I+ ++ R+++ + + + + +
Sbjct: 1925 EVNLQMDAQE-----RPRDVSSADLVIKNQQGIKAEIEARADRFSSCIDMGKELLARSHY 1979
Query: 1464 SLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEIST 1523
+ + + E+ L+ ++E EK +E W+ + + L AG ++ + S+E
Sbjct: 1980 AAEEISEKLSQLQARRQETAEKWQEKMDWLQLVLEVLVFGRDAG---MAEAWLCSQEPLV 2036
Query: 1524 KKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSG 1583
+ +L + ++ + +H +K +E + L E L L+E +
Sbjct: 2037 RSAELGCTVDEVESLIKRH---------EAFQKSAVAWEERFCAL--EKLTALEEREKER 2085
Query: 1584 DVKVEEK 1590
K EE+
Sbjct: 2086 KRKREEE 2092
Score = 33.5 bits (75), Expect = 6.0
Identities = 24/100 (24%), Positives = 45/100 (45%), Gaps = 8/100 (8%)
Query: 646 KFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIE----EFESSLKEAKIS 701
K V++L+ W+DE+ +Q+D E D+ S + ++N + + IE F S + K
Sbjct: 1914 KAVRELMLWMDEVNLQMDAQERPRDVSSADLVIKNQQGIKAEIEARADRFSSCIDMGK-- 1971
Query: 702 EIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTL 741
++ A E +L A+ T+ + +D L
Sbjct: 1972 --ELLARSHYAAEEISEKLSQLQARRQETAEKWQEKMDWL 2009
>gi|112382252 spectrin, beta, non-erythrocytic 1 isoform 2 [Homo
sapiens]
Length = 2155
Score = 311 bits (798), Expect = 9e-84
Identities = 195/455 (42%), Positives = 266/455 (58%), Gaps = 39/455 (8%)
Query: 25 SQKSGSASPAPGDTLPWNLPKHERSKRKIQGGSVLDPAERAVLRIADERDKVQKKTFTKW 84
S SG SPA +P+N + E +++Q DER+ VQKKTFTKW
Sbjct: 7 SSISGPLSPAYTGQVPYNYNQLEGRFKQLQ----------------DEREAVQKKTFTKW 50
Query: 85 INQHLMKVRKHVNDLYEDLRDGHNLISLLEVLSGDTLPRE-KGRMRFHRLQNVQIALDYL 143
+N HL +V + DLY DLRDG LI LLEVLSG+ LP+ KGRMR H L+NV AL +L
Sbjct: 51 VNSHLARVSCRITDLYTDLRDGRMLIKLLEVLSGERLPKPTKGRMRIHCLENVDKALQFL 110
Query: 144 KRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIHVTGES--EDMSAKERLLLWT 201
K ++V L N+ + DI DGN +LTLGLIWTIIL FQI DI V E E SAK+ LLLW
Sbjct: 111 KEQRVHLENMGSHDIVDGNHRLTLGLIWTIILRFQIQDISVETEDNKEKKSAKDALLLWC 170
Query: 202 QQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAVQSNLANLEHAFYVAEK 261
Q T GY + NFTT WRDG FNA+IHK+RPDLID + + + NL++AF +AE+
Sbjct: 171 QMKTAGYPNVNIHNFTTSWRDGMAFNALIHKHRPDLIDFDKLKKSNAHYNLQNAFNLAEQ 230
Query: 262 -IGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAFPKVPE---GGEGIGA---NDVEV-KW 313
+G+ +LLDPED+ V PDEKS+ITYV + Y F K+ G+ IG N +E K
Sbjct: 231 HLGLTKLLDPEDISVDHPDEKSIITYVVTYYHYFSKMKALAVEGKRIGKVLDNAIETEKM 290
Query: 314 IE-YQNMVNYLIQWIRHHVTTMSERTFPNNPVELKALYNQYLQFKETEIPPKETEKSKIK 372
IE Y+++ + L++WI + ++ R F N+ V ++ + ++ E PPK TEK ++
Sbjct: 291 IEKYESLASDLLEWIEQTIIILNNRKFANSLVGVQQQLQAFNTYRTVEKPPKFTEKGNLE 350
Query: 373 RLYKLLEIWIEFGRIKLL---QGYHPNDIEKEWGKLIIAMLEREKALRPEVERLEMLQQI 429
L ++ + K+ +G +DI K W +L A ERE ALR E+ R E L+Q+
Sbjct: 351 VLLFTIQSKMRANNQKVYMPREGKLISDINKAWERLEKAEHERELALRNELIRQEKLEQL 410
Query: 430 ANRVQRDSVICEDKLILAGNALQSDSKRLESGVQF 464
A R R + + E L S+++RL S F
Sbjct: 411 ARRFDRKAAMRETWL--------SENQRLVSQDNF 437
Score = 232 bits (592), Expect = 7e-60
Identities = 339/1666 (20%), Positives = 713/1666 (42%), Gaps = 121/1666 (7%)
Query: 3318 HDLDDVNAR-------WKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVA 3370
HD+ + AR W+ L + + R +L+ L FQ+ L ++ WM + + LV
Sbjct: 481 HDIKRITARKDNVIRLWEYLLELLRARRQRLEMNLGLQKIFQEMLY-IMDWMDEMKVLVL 539
Query: 3371 NQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAE---PADKVKILK 3427
+Q V+ +Q+ L++ + + V + +K AT E P D I
Sbjct: 540 SQDY-GKHLLGVEDLLQKHTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRD 598
Query: 3428 QLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQ 3487
+++ ++ ++ L A R +LE + + F E E W+ EK +++ + G
Sbjct: 599 RVAHMEFCYQELCQLAAERRARLEESRRLWKFFWEMAEE-EGWIREKEK-ILSSDDYGKD 656
Query: 3488 ASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIE 3547
+ + +++H+A ED++ + H QA+ G+ + + + ++ ++ + + +
Sbjct: 657 LTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDM-IAEEHFGSEKIRERIIYIREQWAN 715
Query: 3548 IQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSV--QDYSTEGLWKQQS 3605
+++ S R + L++A + F D ++ W+ ++ +S V +YST+ L K+
Sbjct: 716 LEQLSAIRKKRLEEASLLHQ-FQADADDIDAWMLDILKIVSSSDVGHDEYSTQSLVKKHK 774
Query: 3606 ELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVA 3665
++ E+I + +D L ++ E ++ +L I+ RYK++ +L+
Sbjct: 775 DVA---EEIANYRPTLDTLHEQASALPQEHA--ESPDVRGRLSGIEERYKEVAELTRLRK 829
Query: 3666 KTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKN 3725
+ L+ L L + + S + W+D+ E L + + K E+ Q R + L+ E N
Sbjct: 830 QALQDTLALYK-MFSEADACELWIDEKEQWLNNMQIPE-KLEDLEVIQHRFESLEPEMNN 887
Query: 3726 NKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQ 3785
+ + +N+++ L+ +E ++ + N R+ + + +K + + +A L Q
Sbjct: 888 QASRVAVVNQIARQLMHSGHPSEKE-IKAQQDKLNTRWSQFRELVDRKKDALLSA-LSIQ 945
Query: 3786 QFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKS 3845
+ + SWI E K + S D+ + A + +++ + + DL K
Sbjct: 946 NYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKE 1005
Query: 3846 GHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWP 3905
K+ + ++ Q++ +L ++ ++ + R L A L QF ++
Sbjct: 1006 AEKLESE-HPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKL-QQFLRDLDDFQS 1063
Query: 3906 WLTETQSIISQ--LPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLE-LS 3962
WL+ TQ+ I+ +P E E L Q H ++ I ++ KM G + + +
Sbjct: 1064 WLSRTQTAIASEDMPNTLTEAEKLLTQ---HENIKNEIDNYEEDYQKMRDMGEMVTQGQT 1120
Query: 3963 PGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHD--KIDQILESLERIVE 4020
+ ++++ A DT ++++ + + R L ++ + D + + L + E ++
Sbjct: 1121 DAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLA 1180
Query: 4021 RLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAK 4080
P ++ IK+Q + + EK+ + ET G +++ D +I++
Sbjct: 1181 HTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVET----GRRLVS-----DGNINSD 1231
Query: 4081 AVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFW--CDHMSLIVTIK--DTQDFIR 4136
+Q+K+D + E +L D +L +KF C +SL + K QD
Sbjct: 1232 RIQEKVDSIDDRHRKNRETASELLMRLKDNRDL-QKFLQDCQELSLWINEKMLTAQDMSY 1290
Query: 4137 DLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSID 4196
D E + +K Q AE + E LD + G +LI+ E + +VK+ +
Sbjct: 1291 D-EARNLHSKWLKHQAFMAELASNK-----EWLDKIEKEGMQLISEKPETEA-VVKEKLT 1343
Query: 4197 ELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLET 4256
L+ W+ L + + +L +A +A + + + W+ ++ S G DL +
Sbjct: 1344 GLHKMWEVLESTTQTKAQRLFDANKAEL-FTQSCADLDKWLHGLESQIQS-DDYGKDLTS 1401
Query: 4257 VKQQIEELKQFKSEAYQQQIEMERLNHQAELLLK--KVTEESDKH--TVQDPLMELKLIW 4312
V +++ + +++ ++ E+E L QA+ L + K T+E D TVQ MEL
Sbjct: 1402 VNILLKKQQMLENQMEVRKKEIEELQSQAQALSQEGKSTDEVDSKRLTVQTKFMELL--- 1458
Query: 4313 DSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELA 4372
E + R+H L A + QF +++ + W+ L + G + + +++ +
Sbjct: 1459 ----EPLNERKHNLL-ASKEIHQFNRDVEDEILWVGERMPLATSTDH-GHNLQTVQLLIK 1512
Query: 4373 KHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRK 4432
K+ LQ ++ HQ ++ + + +++ S+ A ++ +L L Q W ++E+TE+R
Sbjct: 1513 KNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEETEKRH 1572
Query: 4433 QQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEA 4492
++L+ A R A+ ++ + + + W+++ E ++++ + ++A L H + A E
Sbjct: 1573 RRLEEAHR-AQQYYFDAAEAEAWMSEQELYMMSEEKAKD-EQSAVSMLKKHQILEQAVED 1630
Query: 4493 KEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAM 4552
ET L + + ++A +E I + + + + ++ ER+ KL+E L
Sbjct: 1631 YAETVHQLSKTSRALVADSHPESE-RISMRQSKVDKLYAGLKDLAEERRGKLDERHRL-F 1688
Query: 4553 EFHNSLQDFINWLTQAEQTLNVASRPSLILD--TVLFQIDEHKVFANEV-NSHREQIIEL 4609
+ + + D W+ + E VA L D V + + FA + N +E++ +
Sbjct: 1689 QLNREVDDLEQWIAEREV---VAGSHELGQDYEHVTMLQERFREFARDTGNIGQERVDTV 1745
Query: 4610 DKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSK 4669
+ L S D I + W +++ + R + L + + K +H+A +
Sbjct: 1746 NHLADEL-INSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDA-KE 1803
Query: 4670 LMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKT 4729
+ +++ K L EL D + ++T H F+ + A + L+
Sbjct: 1804 IFGRIQDKHKKLPEEL--GRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAARLQAAY 1861
Query: 4730 S--LADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRV 4787
+ ADD K + +E+ + W ++ R+ +L + +F ++ L+ W+ V
Sbjct: 1862 AGDKADDIQKRE---NEVLEAWKSLLDACESRRVRLVDT-GDKFRFFSMVRDLMLWMEDV 1917
Query: 4788 EPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVK 4847
Q+ E Q D+ V L++NH+ + E+ R S + L+ S +K
Sbjct: 1918 IRQI-EAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARKHYASEEIK 1976
Query: 4848 VQMQELS-----------TRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAE 4896
++ +L+ RWE + RL + Q SV A WL E
Sbjct: 1977 EKLLQLTEKRKEMIDKWEDRWEWL---------RLILEVHQFSRDASVAEA---WLLGQE 2024
Query: 4897 QTLRFHGVLPDDEDALRTLIDQHKEFMKKL---EEKRAELNKATTM 4939
L + D + LI +H+ F K +E+ + L + TT+
Sbjct: 2025 PYLSSREI-GQSVDEVEKLIKRHEAFEKSAATWDERFSALERLTTL 2069
Score = 214 bits (546), Expect = 1e-54
Identities = 360/1878 (19%), Positives = 769/1878 (40%), Gaps = 161/1878 (8%)
Query: 3214 KQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQ 3273
K+ K+LD A E+ +E + +++ I+L + G + Q
Sbjct: 275 KRIGKVLDNAIETEKMIEKYESLASDLLEWIEQTIIILNNRKFANSLVG--------VQQ 326
Query: 3274 QLNMFKVFQKEEIEPL---QGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTL 3330
QL F ++ E P +G + + + Q +++ + + D+N W+ L
Sbjct: 327 QLQAFNTYRTVEKPPKFTEKGNLEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWERL 386
Query: 3331 NKKVAQRAAQLQEALLHCGRFQDALESLL-----------SWMVDTEELVANQKPPSAEF 3379
K +R L+ L+ Q+ LE L +W+ + + LV +Q +
Sbjct: 387 EKAEHERELALRNELIR----QEKLEQLARRFDRKAAMRETWLSENQRLV-SQDNFGFDL 441
Query: 3380 KVVKAQIQEQKLLQ---RLLDDRKSTVEVIKREGEKIATTAEPADKVK-ILKQLSLLDSR 3435
V+A ++ + ++ ++R V + RE E AE +K I + +
Sbjct: 442 PAVEAATKKHEAIETDIAAYEERVQAVVAVARELE-----AENYHDIKRITARKDNVIRL 496
Query: 3436 WEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQI 3495
WE LL R ++LE +++ Q+ + + + +W+ + K LV + G +E+ +
Sbjct: 497 WEYLLELLRARRQRLE-MNLGLQKIFQEMLYIMDWMDEM-KVLVLSQDYGKHLLGVEDLL 554
Query: 3496 AQHKALEDDI-------INHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEI 3548
+H +E DI N + + G+ K D +++ ++ + Y E+
Sbjct: 555 QKHTLVEADIGIQAERVRGVNASAQKFATDGEGYKPC----DPQVIRDRVAHMEFCYQEL 610
Query: 3549 QEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTE--GLWKQQSE 3606
+ + R L+++ K F E E W+ E K LS DY + + + S+
Sbjct: 611 CQLAAERRARLEESRRLWKFFWE-MAEEEGWIRE---KEKILSSDDYGKDLTSVMRLLSK 666
Query: 3607 LRVLQEDILLRKQNVDQALLNGLELL-KQTTGDEVLIIQDKLEAIKARYKDITKLSTDVA 3665
R ++++ R + +QA+ G +++ ++ G E I++++ I+ ++ ++ +LS
Sbjct: 667 HRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEK--IRERIIYIREQWANLEQLSAIRK 724
Query: 3666 KTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRP-KELKKEAK 3724
K LE+A L + + +++ W+ +++ + + V E ++Q+ ++ K++ +E
Sbjct: 725 KRLEEA-SLLHQFQADADDIDAWM--LDILKIVSSSDVGHDEYSTQSLVKKHKDVAEEIA 781
Query: 3725 NNKALLDSLNEVSSALLELVPWRAREG--LEKMVAEDNERYRLVSDTITQKVEEIDAAIL 3782
N + LD+L+E +SAL P E + ++ ERY+ V++ + + + +
Sbjct: 782 NYRPTLDTLHEQASAL----PQEHAESPDVRGRLSGIEERYKEVAELTRLRKQALQDTLA 837
Query: 3783 RSQQFDQAADAELSWITETEKKLMS------LGDIRLEQDQTSAQLQVQKTFTMEILRHK 3836
+ F +A EL WI E E+ L + L D+ + Q + + +
Sbjct: 838 LYKMFSEADACEL-WIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVN 896
Query: 3837 DIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQF 3896
I L+ SGH SE+E +K + DK+ + ++ + L A S+ N
Sbjct: 897 QIARQLMHSGHP-----SEKE---IKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYH 948
Query: 3897 WETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGP 3956
E E W+ E +I + + Q + + + + + + K
Sbjct: 949 LEC-NETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAE 1007
Query: 3957 QLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLE 4016
+L P + +I + ++ ++K +K R +L EA S+ QF +D L
Sbjct: 1008 KLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEA-SKLQQFLRDLDDFQSWLS 1066
Query: 4017 RIVERL--RQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTD 4074
R + P+ E EK+ +++++N+ +++ + Y+ ++ GE + G TD
Sbjct: 1067 RTQTAIASEDMPNTLTEAEKL---LTQHENIKNEIDNYEEDYQKMRDMGE--MVTQGQTD 1121
Query: 4075 KDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDF 4134
++ +L + W +H + E R+ LL ++F D + + +
Sbjct: 1122 AQY--MFLRQRLQALDTGWNELHKMWENRQ-NLLSQSHAYQQFLRDTKQAEAFLNNQEYV 1178
Query: 4135 IRDLEDP----GIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPI 4190
+ E P G + ++ KQ E +D +E+++ V+ G L++ G +
Sbjct: 1179 LAHTEMPTTLEGAEAAIKKQ-----EDFMTTMDANEEKINAVVETGRRLVSD-GNINSDR 1232
Query: 4191 VKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPI 4250
+++ +D ++ + + + +L++ QD Q + W++ K+ + +
Sbjct: 1233 IQEKVDSIDDRHRKNRETASELLMRLKDNRDLQKFLQD-CQELSLWIN---EKMLTAQDM 1288
Query: 4251 GTD-LETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELK 4309
D + + + + F +E + ++++ + L+ + E + V++ L L
Sbjct: 1289 SYDEARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQLISEKPE--TEAVVKEKLTGLH 1346
Query: 4310 LIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEI 4369
+W+ LE + +L A A F + +L WL E + + G D ++ I
Sbjct: 1347 KMWEVLESTTQTKAQRLFDANKA-ELFTQSCADLDKWLHGLESQI-QSDDYGKDLTSVNI 1404
Query: 4370 ELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTE 4429
L K +L+N + + +E + L S G+ + +K + ++ +LE
Sbjct: 1405 LLKKQQMLENQMEVRKKEIEELQSQAQAL--SQEGKSTDEVDSKRLTVQTKFMELLEPLN 1462
Query: 4430 QRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAA 4489
+RK L A ++ F+ ++ED W+ + L S G +T + + + +
Sbjct: 1463 ERKHNL-LASKEIHQFNRDVEDEILWVGE-RMPLATSTDHGHNLQTVQLLIKKNQTLQKE 1520
Query: 4490 FEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALN 4549
+ + + ++ Q ++ + I Q + +LK+ W + + +R +LEEA +
Sbjct: 1521 IQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEETEKRHRRLEEA-H 1579
Query: 4550 LAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIEL 4609
A +++ + W+++ E + ++ + + + + +H++ V + E + +L
Sbjct: 1580 RAQQYYFDAAEAEAWMSEQELYM-MSEEKAKDEQSAVSMLKKHQILEQAVEDYAETVHQL 1638
Query: 4610 DKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKV---VQRLVERGRSLDDARKRAKQFHEA 4666
KT L S + + QS+ +K+ ++ L E R D R R Q +
Sbjct: 1639 SKTSRALVADSHPE-----SERISMRQSKVDKLYAGLKDLAEERRGKLDERHRLFQLNRE 1693
Query: 4667 WSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLG-AKHSVYDTTNRTGRSL 4725
L +W+ E E S E+ D + + + +EF + G DT N L
Sbjct: 1694 VDDLEQWIAEREVVAGSH-ELGQDYEHVTMLQERFREFARDTGNIGQERVDTVNHLADEL 1752
Query: 4726 -----KEKTSLADDNLKLDDMLSELRDKWDT---ICGKSVERQNKLEEALLFSGQFTDAL 4777
+ ++A+ L++ ++L + DT I S E +A G+ D
Sbjct: 1753 INSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDAKEIFGRIQDKH 1812
Query: 4778 QALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIE 4837
+ L + L R D + V L H F+ ++ + V+ L+ A L
Sbjct: 1813 KKLPEELGR-------------DQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAARLQA 1859
Query: 4838 G-SRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAE 4896
+ D + ++ + E+ W+++ S++ RL F S+V L+ W+ +
Sbjct: 1860 AYAGDKADDIQKRENEVLEAWKSLLDACESRRVRL-VDTGDKFRFFSMVRDLMLWMEDVI 1918
Query: 4897 QTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIK 4956
+ + P D ++ L++ H+ +++ + +G ++LA H S +
Sbjct: 1919 RQIEAQ-EKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARKHYASEEIKE 1977
Query: 4957 HWITIIRARFEEVLAWAKQHQ-QRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEV 5015
+ + R E + W + + RL + + E AWL E L+ ++
Sbjct: 1978 KLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAE---AWLLGQEPYLSSRE--- 2031
Query: 5016 IPQEIEEVKALIAEHQTF 5033
I Q ++EV+ LI H+ F
Sbjct: 2032 IGQSVDEVEKLIKRHEAF 2049
Score = 209 bits (533), Expect = 5e-53
Identities = 320/1645 (19%), Positives = 687/1645 (41%), Gaps = 105/1645 (6%)
Query: 3427 KQLSLLDSRWEALLNKAETRNRQL-------EGISVVAQQFHETLEPLNEWLTTIEKRLV 3479
K +S ++ WE L R L E + +A++F WL+ +RLV
Sbjct: 374 KLISDINKAWERLEKAEHERELALRNELIRQEKLEQLARRFDRKAAMRETWLSE-NQRLV 432
Query: 3480 NCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLD 3539
+ + G +E +H+A+E DI + + + V++ + L+ + + K + K +
Sbjct: 433 SQDNFGFDLPAVEAATKKHEAIETDIAAYEERVQAVVAVARELEAENYHDIKRITARKDN 492
Query: 3540 FSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTE- 3598
++W + E +R + L+ L KIF ++ + +M+W++E+ K+ LS QDY
Sbjct: 493 VIRLWEY-LLELLRARRQRLEMNLGLQKIF-QEMLYIMDWMDEM--KVLVLS-QDYGKHL 547
Query: 3599 -GLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTG---DEVLIIQDKLEAIKARY 3654
G+ + +++ DI ++ + V + + G + +I+D++ ++ Y
Sbjct: 548 LGVEDLLQKHTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCY 607
Query: 3655 KDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQM 3714
+++ +L+ + LE++ +L + EE W+ + E ++LS + +
Sbjct: 608 QELCQLAAERRARLEESRRLWKFFWEMAEEE-GWIREKE-KILSSDDYGKDLTSVMRLLS 665
Query: 3715 RPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKV 3774
+ + + E + + ++ + + + E+++ + L + +K
Sbjct: 666 KHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKK 725
Query: 3775 EEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILR 3834
+A++L QF AD +W+ + K++S D+ ++ T + ++ K EI
Sbjct: 726 RLEEASLL--HQFQADADDIDAWMLDI-LKIVSSSDVGHDEYSTQSLVKKHKDVAEEIAN 782
Query: 3835 HKDIIDDLVKSGHKIMTACSEEEKQS--MKKKLDKVLKNYDTICQINSERYLQLERAQSL 3892
++ +D L H+ +A +E +S ++ +L + + Y + ++ R L+ +L
Sbjct: 783 YRPTLDTL----HEQASALPQEHAESPDVRGRLSGIEERYKEVAELTRLRKQALQDTLAL 838
Query: 3893 VNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMN 3952
F E + W+ E + ++ + P + E L Q L + + +N
Sbjct: 839 YKMFSEA-DACELWIDEKEQWLNNMQIPE-KLEDLEVIQHRFESLEPEMNNQASRVAVVN 896
Query: 3953 KTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQIL 4012
+ QL+ I+ + +T +SQ +E V ++ AL A+S +H + ++
Sbjct: 897 QIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRELVDRKKDALLSALS-IQNYHLECNETK 955
Query: 4013 ESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGG 4072
+ + + + ++ + + + D+ ++ L++ E++
Sbjct: 956 SWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKL-----E 1010
Query: 4073 TDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQ 4132
++ A+A+ +L ++ +WE + T ++ REA L + +L ++F D + TQ
Sbjct: 1011 SEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKL-QQFLRDLDDFQSWLSRTQ 1069
Query: 4133 DFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVK 4192
I + P K + E I+ EID +E+ + ++G + + ++
Sbjct: 1070 TAIASEDMPNTLTEAEKLLTQ-HENIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLR 1128
Query: 4193 KSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGT 4252
+ + L++ W+ L+K W++R + L ++ A Q+ + +++ LA + + T
Sbjct: 1129 QRLQALDTGWNELHKMWENRQNLLSQS-HAYQQFLRDTKQAEAFLNNQEYVLAH-TEMPT 1186
Query: 4253 DLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIW 4312
LE + I++ + F + E++N E + V SD + D + E
Sbjct: 1187 TLEGAEAAIKKQEDFMT---TMDANEEKINAVVETGRRLV---SDGNINSDRIQEKV--- 1237
Query: 4313 DSLEERIINRQHKLEGALLA------LGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKA 4366
DS+++R + L+ L +F EL W+ E +L+ Q + +
Sbjct: 1238 DSIDDRHRKNRETASELLMRLKDNRDLQKFLQDCQELSLWI--NEKMLTAQDMSYDEARN 1295
Query: 4367 IEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLE 4426
+ + KH ++ +++ ++ + K G LI EA ++ KL L++ W+ VLE
Sbjct: 1296 LHSKWLKHQAFMAELASNKEWLDKIEKEGMQLISEKPETEAV-VKEKLTGLHKMWE-VLE 1353
Query: 4427 KTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLA---SKPLGGLPETAKEQLNVH 4483
T Q K Q +A+ F DL +WL E + + K L + K+Q +
Sbjct: 1354 STTQTKAQRLFDANKAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQMLE 1413
Query: 4484 MEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTK 4543
++ + EE +Q Q L++ KS + +D ++ K+ + LNERK
Sbjct: 1414 NQMEVRKKEIEE-----LQSQAQALSQEGKSTD-EVDSKRLTVQTKFMELLEPLNERKHN 1467
Query: 4544 LEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHR 4603
L + + +F+ ++D I W+ + L ++ L TV I +++ E+ H+
Sbjct: 1468 LLASKEI-HQFNRDVEDEILWVGE-RMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQ 1525
Query: 4604 EQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQF 4663
+I ++ + ++ S I+ L ++ W +++ +R R L++A RA+Q+
Sbjct: 1526 PRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEETEKRHRRLEEAH-RAQQY 1584
Query: 4664 HEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGR 4723
+ ++ W+ E E + SE E A D + L +H+ ++++ ++T R
Sbjct: 1585 YFDAAEAEAWMSEQELYMMSE-EKAKDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSR 1643
Query: 4724 SL-----KEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEA-LLFSGQFTDAL 4777
+L E ++ K+D + + L+D + ER+ KL+E LF Q +
Sbjct: 1644 ALVADSHPESERISMRQSKVDKLYAGLKD-------LAEERRGKLDERHRLF--QLNREV 1694
Query: 4778 QALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGK-RTSSVQALKRSARELI 4836
L W+ E +A + D + V L + + F ++ G V + A ELI
Sbjct: 1695 DDLEQWIAERE-VVAGSHELGQDYEHVTMLQERFREFARDTGNIGQERVDTVNHLADELI 1753
Query: 4837 EGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAE 4896
D++ + L+ W + L I +T++ AA + E H H E +
Sbjct: 1754 NSGHSDAATIAEWKDGLNEAWADLLEL-IDTRTQILAA---SYELHKFYHDAKEIFGRIQ 1809
Query: 4897 QTLRFHGVLPD----DEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSI 4952
H LP+ D++ + TL H F ++ ++ + + A D
Sbjct: 1810 DK---HKKLPEELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAARLQAAYAGDKA 1866
Query: 4953 TTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKD 5012
I+ + ++ +L + + RL K + + W E + +
Sbjct: 1867 DDIQKRENEVLEAWKSLLDACESRRVRLVDT----GDKFRFFSMVRDLMLWMEDVIRQIE 1922
Query: 5013 KEVIPQEIEEVKALIAEHQTFMEEM 5037
+ P+++ V+ L+ HQ E+
Sbjct: 1923 AQEKPRDVSSVELLMNNHQGIKAEI 1947
Score = 162 bits (409), Expect = 1e-38
Identities = 251/1319 (19%), Positives = 543/1319 (41%), Gaps = 103/1319 (7%)
Query: 3785 QQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILR------HKDI 3838
++++ A L WI +T ++ L + + Q Q+Q T + K
Sbjct: 292 EKYESLASDLLEWIEQT---IIILNNRKFANSLVGVQQQLQAFNTYRTVEKPPKFTEKGN 348
Query: 3839 IDDLVKSGHKIMTACSEEEKQSMKKKL-DKVLKNYDTICQINSERYLQL-------ERAQ 3890
++ L+ + M A +++ + KL + K ++ + + ER L L E+ +
Sbjct: 349 LEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWERLEKAEHERELALRNELIRQEKLE 408
Query: 3891 SLVNQFWETYEELWPWLTETQSIISQ----LPAPALEYETLRQQQEEHRQLRELIAEHKP 3946
L +F WL+E Q ++SQ PA+E T ++H + IA ++
Sbjct: 409 QLARRFDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAAT-----KKHEAIETDIAAYEE 463
Query: 3947 HIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHD 4006
+ + +L + + I + L+ + E ++ R L+ + F +
Sbjct: 464 RVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEMNLGLQKIFQE 523
Query: 4007 KIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEM 4066
+ I++ ++ + + L + +++ + ++ V D+ + + RG
Sbjct: 524 ML-YIMDWMDEM-KVLVLSQDYGKHLLGVEDLLQKHTLVEADIG-----IQAERVRGVNA 576
Query: 4067 IARSGGTD----KDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHM 4122
A+ TD K + ++D++ M F ++ + L ER A+L + L + FW
Sbjct: 577 SAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQELCQLAAERRARLEESRRLWKFFW---- 632
Query: 4123 SLIVTIKDTQDFIRDLE------DPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLG 4176
+ + + +IR+ E D G D + V + +E+ G + I G
Sbjct: 633 ----EMAEEEGWIREKEKILSSDDYGKDLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEG 688
Query: 4177 SELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDW 4236
++IA + I ++ I + W +L + R +LEEA Q+Q + W
Sbjct: 689 EDMIAEEHFGSEKI-RERIIYIREQWANLEQLSAIRKKRLEEA-SLLHQFQADADDIDAW 746
Query: 4237 V-DIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEE 4295
+ DI K+ S S +G D + + +++ K E + ++ L+ QA L ++ E
Sbjct: 747 MLDIL--KIVSSSDVGHDEYSTQSLVKKHKDVAEEIANYRPTLDTLHEQASALPQEHAES 804
Query: 4296 SDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLS 4355
D V+ L ++ + + E R+ L+ L F A D W+ E L+
Sbjct: 805 PD---VRGRLSGIEERYKEVAELTRLRKQALQDTLALYKMFSEA-DACELWIDEKEQWLN 860
Query: 4356 EQKPVGGDPKAIE-IELAKHHV--LQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQN 4412
+ P+ +E +E+ +H L+ ++ S V VN+ L+ S E ++
Sbjct: 861 NMQI----PEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQLMHSGHPSE-KEIKA 915
Query: 4413 KLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLG-- 4470
+ + LN RW E +++K L AL + +H E + + W+ + + + +++ LG
Sbjct: 916 QQDKLNTRWSQFRELVDRKKDALLSAL-SIQNYHLECNETKSWIREKTKVIESTQDLGND 974
Query: 4471 --GLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKE 4528
G+ ++ + ++ A EAK L ++ +++ + P A+ + + + + +
Sbjct: 975 LAGVMALQRKLTGMERDL-VAIEAK---LSDLQKEAEKLESEHPDQAQAILSR-LAEISD 1029
Query: 4529 KWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQ 4588
WE ++T L R+ L EA L +F L DF +WL++ + + P+ + +
Sbjct: 1030 VWEEMKTTLKNREASLGEASKL-QQFLRDLDDFQSWLSRTQTAIASEDMPNTLTEAEKL- 1087
Query: 4589 IDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVE 4648
+ +H+ NE++++ E ++ G + + ++ L ++ + W ++ ++ E
Sbjct: 1088 LTQHENIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLRQRLQALDTGWNEL-HKMWE 1146
Query: 4649 RGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSL 4708
++L +QF + +L E L + E+ + + + + ++F ++
Sbjct: 1147 NRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVL-AHTEMPTTLEGAEAAIKKQEDFMTTM 1205
Query: 4709 GAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALL 4768
A + TGR L ++D N+ D +++K D+I + + + E L+
Sbjct: 1206 DANEEKINAVVETGRRL-----VSDGNINSD----RIQEKVDSIDDRHRKNRETASELLM 1256
Query: 4769 FSGQFTDALQALIDW----LYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSS 4824
D + L D L+ E L + + + + H+AF EL
Sbjct: 1257 RLKDNRDLQKFLQDCQELSLWINEKMLTAQDMSYDEARNLHSKWLKHQAFMAELASNKEW 1316
Query: 4825 VQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSV 4884
+ +++ +LI + + VK ++ L WE + + + +K RL A +AE F
Sbjct: 1317 LDKIEKEGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDA-NKAELFTQS 1375
Query: 4885 VHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVL 4944
L +WL E ++ D ++ L+ + + ++E ++ E+ + + +
Sbjct: 1376 CADLDKWLHGLESQIQSDDY-GKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQAQALS 1434
Query: 4945 AICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWA 5004
S + ++ +F E+L + + L ++ +++ + +L W+
Sbjct: 1435 Q--EGKSTDEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEIL-WVGER 1491
Query: 5005 ETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQS 5063
T D ++ V+ LI ++QT +E+ QP +D + + + D SSL +
Sbjct: 1492 MPLATSTDHG---HNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSA 1547
Score = 149 bits (375), Expect = 1e-34
Identities = 333/1806 (18%), Positives = 719/1806 (39%), Gaps = 200/1806 (11%)
Query: 1511 FSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFS 1570
FSK K + E + L A++T ++ +K + LE +T+ N F+
Sbjct: 264 FSKMKALAVEGKRIGKVLDNAIETEKMI-----EKYESLASDLLEWIEQTIIILNNRKFA 318
Query: 1571 ESL----KQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMI 1626
SL +QLQ T V E+ ++ EK L T +Q+ +M
Sbjct: 319 NSLVGVQQQLQAFNTYRTV--------EKPPKFTEKGNLEVLLFTIQSKMRANNQKVYMP 370
Query: 1627 GDGTV---------ELKKYQSKQE-----EL--QKDMQGSAQALAEVVKNTENFLKENGE 1670
+G + L+K + ++E EL Q+ ++ A+ E +L EN
Sbjct: 371 REGKLISDINKAWERLEKAEHERELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQR 430
Query: 1671 KLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESK 1730
+SQ++ + A K E + ++ + VV A + E E +K++ K
Sbjct: 431 LVSQDNFGFDLPAVEAATKKHEAIETDIAAYEERVQAVVAVARELEAENYHDIKRITARK 490
Query: 1731 TKIENLLDWLSNVDKDSERAGTKHKQVIEQN-GTHFQEGDGKSAIGEEDEVNGNLLETDV 1789
+ L ++L + + +Q +E N G + + DE+ +L D
Sbjct: 491 DNVIRLWEYLLELLR-------ARRQRLEMNLGLQKIFQEMLYIMDWMDEMKVLVLSQDY 543
Query: 1790 DGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQK 1849
G+ E+L Q++ V+A I Q + V SAQ G+ P + + ++
Sbjct: 544 -GKHLLGVEDLLQKHTLVEAD---IGIQAERVRGVNASAQ-KFATDGEGYKPCDPQVIRD 598
Query: 1850 NMKELKVHY-ETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGAD 1908
+ ++ Y E +E++ +L S L KF + E E W+++ E+ L + + G
Sbjct: 599 RVAHMEFCYQELCQLAAERRARLEES--RRLWKFFWEMAEEEGWIREKEKILSSDDYG-K 655
Query: 1909 DINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREV 1968
D+ +M L + ++F +++ G G ++ S++ +
Sbjct: 656 DLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEK-------------I 702
Query: 1969 QRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHL-SE 2027
+ ++ + +++ +L + L++ +Q DA + A K + S
Sbjct: 703 RERIIYIREQWANLEQLSAIRKKRLEEASLLHQFQADAD-----DIDAWMLDILKIVSSS 757
Query: 2028 PIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDD 2087
+ D + Q +++ K + +I++ + ++ L + A L D++ L
Sbjct: 758 DVGHDEYSTQSLVKKHKDVAEEIANYRPTLDTLHEQASALPQEHAE----SPDVRGRLSG 813
Query: 2088 IVGRYEDLSKSVNERNEKLQITLT--RSLSVQDG----LDEMLDWMGNVESSLKEQGQVP 2141
I RY+++++ R + LQ TL + S D +DE W+ N+ Q+P
Sbjct: 814 IEERYKEVAELTRLRKQALQDTLALYKMFSEADACELWIDEKEQWLNNM--------QIP 865
Query: 2142 LNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPS--TASSLQAKMKDLSA 2199
L+ I + LE ++ + S + +N+ ++ M + PS + Q K+ +
Sbjct: 866 EKLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWS 925
Query: 2200 RFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQY 2259
+F E + K+ L ++ + + ++++ KT+ + G D+ +
Sbjct: 926 QFRELVDRKKDALLS----ALSIQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMAL 981
Query: 2260 MQESTS---EFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKE 2316
++ T + + + L L +++ S P +L + +S ++EM+ T+K
Sbjct: 982 QRKLTGMERDLVAIEAKLSDLQKEAEKLESEH-PDQAQAILSRLAEISDVWEEMKTTLK- 1039
Query: 2317 KKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWS 2376
+EA +L F + +SW+ T Q + +ED+ +L + +KL +
Sbjct: 1040 NREASLGEASKLQQFLRDLDDFQSWLSRT-------QTAIASEDMPNTLTEAEKLLTQHE 1092
Query: 2377 LKTPEI-------QKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFW 2429
EI QK+ + G +++ T A+ + + A+ G + W
Sbjct: 1093 NIKNEIDNYEEDYQKMRDMG----EMVTQGQTDAQYMFLRQRLQALDTG---WNELHKMW 1145
Query: 2430 ANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKT 2489
N ++++ SH Y+ K A LN + L
Sbjct: 1146 EN------RQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVL-------------------- 1179
Query: 2490 ATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRW 2549
T PT E + +++ + F + N K+ + + L+ + + R
Sbjct: 1180 ----AHTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDG--NINSDRI 1233
Query: 2550 KQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLS 2609
++ + ID + ++ + + +L++ + +L +F +L W+ EK L +S
Sbjct: 1234 QEKVDSIDDRHRKNRETASELLMRLKD-NRDLQKFLQDCQELSLWINEKMLTAQ---DMS 1289
Query: 2610 ID-PNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVT 2668
D L+++ + Q + E A+ K +++ G ++S E P +VKE+L +
Sbjct: 1290 YDEARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQLIS---EKPETEAVVKEKLTGLH 1346
Query: 2669 QKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQ 2728
+ W+ L + + A K+ + L L L++++ S ++N
Sbjct: 1347 KMWEVLESTTQTKAQRLFDA-NKAELFTQSCADLDKWLHGLESQIQSD-DYGKDLTSVNI 1404
Query: 2729 QLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKA 2788
L+ Q ++ +++ KK+I+ Q+ + AL +E E+ + + F ++ +
Sbjct: 1405 LLKKQQMLENQMEVRKKEIEELQSQAQ---ALSQEGKSTDEVDSKRLTVQTKFMELLEPL 1461
Query: 2789 ENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSK 2848
N +H A HQF + D W+ ++ S L ++ LIK ++ K
Sbjct: 1462 -NERKHNLLASKEIHQFNRDVEDEILWVG-ERMPLATSTDHGHNLQTVQLLIKKNQTLQK 1519
Query: 2849 TLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESL 2908
+ + +N++ + A++ +L +K W ++ ++R +L+E+
Sbjct: 1520 EIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEETEKRHRRLEEA- 1578
Query: 2909 EKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELL 2968
+A +Y W+ + + + + D + + K + L++ ++ + V L
Sbjct: 1579 HRAQQYYFDAAEAEAWMSEQELYMMSEEKAKDEQSAVSMLKKHQILEQAVEDYAETVHQL 1638
Query: 2969 NNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKES 3028
+ T+ +L++ + E ++ + + + + ++ L+ + F+ +EV +
Sbjct: 1639 SKTSRALVADSHPESERISMRQSKVDKLYAGLKDLAEERRGKLDERHRLFQLNREV--DD 1696
Query: 3029 KRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSL-----QALKHQVDLAKRLAQDLV 3083
Q +E + LG Q Y +++TMLQ + + + +VD LA +L+
Sbjct: 1697 LEQWIAEREVVAGSHELG-QDY--EHVTMLQERFREFARDTGNIGQERVDTVNHLADELI 1753
Query: 3084 VEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQ------GIGHFQNTIREM 3137
+ G SD TIA+ L++ + ++T+ Q + F + +E+
Sbjct: 1754 -----NSGHSD----AATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDAKEI 1804
Query: 3138 FSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLA--T 3195
F + + +L +GRD T++ + F ++AL + + A
Sbjct: 1805 FGRIQDKHKKLPE--ELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAARLQAAYA 1862
Query: 3196 EETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAE 3255
+ + D+ KR+ E L + LLD ++R ++ T + F+S +++ + ++
Sbjct: 1863 GDKADDIQ--KRENEVL-EAWKSLLDACESRRVRLVDTGDKF-RFFSMVRDLMLWMEDVI 1918
Query: 3256 EHEESQ 3261
E+Q
Sbjct: 1919 RQIEAQ 1924
Score = 137 bits (345), Expect = 3e-31
Identities = 280/1593 (17%), Positives = 637/1593 (39%), Gaps = 158/1593 (9%)
Query: 3542 QVWYIEIQEKSHSRSELLQQAL---CNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTE 3598
Q+ I ++ + + + + AL C K G V + N+ D ++ ++
Sbjct: 145 QIQDISVETEDNKEKKSAKDALLLWCQMKTAGYPNVNIHNFTTSWRDGMAFNAL------ 198
Query: 3599 GLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEA--------- 3649
+ K + +L + L+K N L N L +Q G L+ + +
Sbjct: 199 -IHKHRPDLIDFDK---LKKSNAHYNLQNAFNLAEQHLGLTKLLDPEDISVDHPDEKSII 254
Query: 3650 --IKARYKDITKLST------DVAKTLEQALQ---LARRLHSTHEELCTWLDKVEVELLS 3698
+ Y +K+ + K L+ A++ + + S +L W+++ + L +
Sbjct: 255 TYVVTYYHYFSKMKALAVEGKRIGKVLDNAIETEKMIEKYESLASDLLEWIEQTIIILNN 314
Query: 3699 --YETQVLKGEEASQAQMRPKELKKEAK-----NNKALLDSLNEVSSALLELVPWRAREG 3751
+ ++ ++ QA + ++K K N + LL ++ A + V + REG
Sbjct: 315 RKFANSLVGVQQQLQAFNTYRTVEKPPKFTEKGNLEVLLFTIQSKMRANNQKV-YMPREG 373
Query: 3752 LEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQ-------FDQAADAELSWITETEKK 3804
K++++ N+ + + ++ + ++R ++ FD+ A +W++E ++
Sbjct: 374 --KLISDINKAWERLEKAEHERELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQR- 430
Query: 3805 LMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKK 3864
L+S + + A + + +I +++ + +V ++ + K+ +K
Sbjct: 431 LVSQDNFGFDLPAVEAATKKHEAIETDIAAYEERVQAVVAVARELEAENYHDIKRITARK 490
Query: 3865 LDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSII--SQLPAPAL 3922
D V++ ++ + ++ R +LE L F E + W+ E + ++ L
Sbjct: 491 -DNVIRLWEYLLELLRARRQRLEMNLGLQKIFQEMLY-IMDWMDEMKVLVLSQDYGKHLL 548
Query: 3923 EYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFS------IQEKYVAA 3976
E L Q+ H + I + +N + + + GEG+ I+++
Sbjct: 549 GVEDLLQK---HTLVEADIGIQAERVRGVNASAQKFA--TDGEGYKPCDPQVIRDRVAHM 603
Query: 3977 DTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIK 4036
+ Y ++ + +R L+E+ F + ++ E R E++ ++ +
Sbjct: 604 EFCYQELCQLAAERRARLEESRRLWKFFWEMAEE--EGWIREKEKILSSDDYGKDLTSVM 661
Query: 4037 EQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENI 4096
+S+++ +M +E + GE+MIA ++ ++ +++++ + W N+
Sbjct: 662 RLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIA-----EEHFGSEKIRERIIYIREQWANL 716
Query: 4097 HTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAE 4156
L R+ K L+ L +F D + + D + D G D + + +
Sbjct: 717 EQLSAIRK-KRLEEASLLHQFQADADDIDAWMLDILKIVSS-SDVGHDEYSTQSLVKKHK 774
Query: 4157 TIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKL 4216
+ EEI + LD + S L E P V+ + + + + + + R L
Sbjct: 775 DVAEEIANYRPTLDTLHEQASALPQEHAE--SPDVRGRLSGIEERYKEVAELTRLRKQAL 832
Query: 4217 EEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGT--DLETVKQQIEELK-----QFKS 4269
++ + + + A W+D L +M DLE ++ + E L+ Q
Sbjct: 833 QDTLALYKMFSEA-DACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASR 891
Query: 4270 EAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGA 4329
A QI + L H K++ + DK L W E + ++ L A
Sbjct: 892 VAVVNQIARQ-LMHSGHPSEKEIKAQQDK---------LNTRWSQFRELVDRKKDALLSA 941
Query: 4330 LLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVE 4389
L ++ + +E +W+ ++ + +G D + K ++ D++A ++ +
Sbjct: 942 L-SIQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLS 1000
Query: 4390 AVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEI 4449
+ K L ES ++A + ++L ++ W+ + + R+ L G + + F ++
Sbjct: 1001 DLQKEAEKL-ESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASL-GEASKLQQFLRDL 1058
Query: 4450 EDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLA 4509
+D Q WL+ T+ +AS+ + A++ L H + + EE Y+ + G+ +
Sbjct: 1059 DDFQSWLSRTQT-AIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMV-- 1115
Query: 4510 RCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAE 4569
+ D L+++ ++++T NE E NL + H + Q F+ QAE
Sbjct: 1116 -----TQGQTDAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSH-AYQQFLRDTKQAE 1169
Query: 4570 QTLN------VASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQ 4623
LN + L+ I + + F ++++ E+I + +TG L
Sbjct: 1170 AFLNNQEYVLAHTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRL-VSDGNI 1228
Query: 4624 DVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDS 4683
+ I+ + S+ R K + E L D R K F + +L W+ +EK L +
Sbjct: 1229 NSDRIQEKVDSIDDRHRKNRETASELLMRLKDNRDLQK-FLQDCQELSLWI--NEKMLTA 1285
Query: 4684 ELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLS 4743
+ ++ + ++ +H+ F L + D + G L + + +K + L+
Sbjct: 1286 QDMSYDEARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQLISEKPETEAVVK--EKLT 1343
Query: 4744 ELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHG-DID 4802
L W+ + + + +L +A + FT + L WL+ +E Q+ D +G D+
Sbjct: 1344 GLHKMWEVLESTTQTKAQRLFDANK-AELFTQSCADLDKWLHGLESQIQSDD--YGKDLT 1400
Query: 4803 LVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCA 4862
V L+ + + ++ R ++ L+ A+ L S++ S +V + L+ + + +
Sbjct: 1401 SVNILLKKQQMLENQMEVRKKEIEELQSQAQAL---SQEGKSTDEVDSKRLTVQTKFMEL 1457
Query: 4863 LS-ISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQ--TLRFHGVLPDDEDALRTLIDQH 4919
L ++++ A ++ +F+ V + W+ E T HG + ++ LI ++
Sbjct: 1458 LEPLNERKHNLLASKEIHQFNRDVEDEILWVGERMPLATSTDHG---HNLQTVQLLIKKN 1514
Query: 4920 KEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQR 4979
+ K+++ + ++ ++ S I+ + ++ + ++ ++ +R
Sbjct: 1515 QTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEETEKRHRR 1574
Query: 4980 LASALAGLIAKQELLEALLAWLQWAETTLTDKDK--------------EVIPQEIEEV-- 5023
L A + EA AW+ E + ++K +++ Q +E+
Sbjct: 1575 LEEAHRAQQYYFDAAEAE-AWMSEQELYMMSEEKAKDEQSAVSMLKKHQILEQAVEDYAE 1633
Query: 5024 ---------KALIAEHQTFMEEMTRKQPDVDKV 5047
+AL+A+ E ++ +Q VDK+
Sbjct: 1634 TVHQLSKTSRALVADSHPESERISMRQSKVDKL 1666
Score = 130 bits (326), Expect = 5e-29
Identities = 345/1826 (18%), Positives = 720/1826 (39%), Gaps = 221/1826 (12%)
Query: 2061 KKTAEVLLDARGSLLPAKNDIQ------KTLDDIVGRYEDLSKSVNERNEKLQITLTRSL 2114
K EVLL S + A N K + DI +E L K+ +ER L+ L R
Sbjct: 346 KGNLEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWERLEKAEHERELALRNELIRQE 405
Query: 2115 SVQ------DGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSI 2168
++ D M + + L Q + A++ K+ +E DIA + +
Sbjct: 406 KLEQLARRFDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAATKKHEAIETDIAAYEERV 465
Query: 2169 NAMNEKVKKFMETTDPSTASSLQAK----MKDLSARFSEASHKHKETLAKMEELKTKVEL 2224
A+ + A L+A+ +K ++AR + L + + ++E+
Sbjct: 466 QAV------------VAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEM 513
Query: 2225 FENLSEKLQTFL-------ETKTQALTEVDVPGKDVTELSQYMQEST---SEFLEHKKHL 2274
L + Q L E K L++ GK + + +Q+ T ++ + +
Sbjct: 514 NLGLQKIFQEMLYIMDWMDEMKVLVLSQDY--GKHLLGVEDLLQKHTLVEADIGIQAERV 571
Query: 2275 EVLHSLLKEISSHG---LPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAF 2331
+++ ++ ++ G P D ++ ++ ++ ++E+ E++ + + F
Sbjct: 572 RGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQELCQLAAERRARLEESRRLWKFF 631
Query: 2332 QVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGIS 2391
+ + + WI+E K + ++D GK L +L K E+ SG
Sbjct: 632 WEMAEE-EGWIREKEKIL-------SSDDYGKDLTSVMRLLSKHRAFEDEMS--GRSG-- 679
Query: 2392 LCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDL 2451
+ A+ IA G + E WAN E L
Sbjct: 680 --HFEQAIKEGEDMIAEEHFGSEKIRER--IIYIREQWAN----------------LEQL 719
Query: 2452 GLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQ 2511
+ K ++ E S L + Q ++ + W+ + K + + D + ++ V++
Sbjct: 720 SAIRKKRLEEA----SLLHQFQADADDIDAWMLDILKIVSS---SDVGHDEYSTQSLVKK 772
Query: 2512 NKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQ 2571
+K E+ + L ++ + L +E+ ++P+ + L+ I+ +++E+ +LT R+
Sbjct: 773 HKDVAEEIANYRPTLDTLHEQASALPQEHAESPDV---RGRLSGIEERYKEVAELTRLRK 829
Query: 2572 QKLEESSNNLTQFQTVEAQLKQWLVEKELMVS------VLGPL--------SIDPNMLNT 2617
Q L+++ F +A + W+ EKE ++ L L S++P M N
Sbjct: 830 QALQDTLALYKMFSEADA-CELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEM-NN 887
Query: 2618 QRQQV----QILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDS 2673
Q +V QI Q + P +++ A + +R + L V +K D+
Sbjct: 888 QASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFREL----------VDRKKDA 937
Query: 2674 LTGQLSDRCDWIDQAIVKSTQYQSLLRSLS---DKLSDLDNKLSSSLAVSTHPDAMNQQL 2730
L LS I ++ + +S +R + + DL N L+ +A+ M + L
Sbjct: 938 LLSALS-----IQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDL 992
Query: 2731 ETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAEN 2790
+ ++Q+E ++++ + +A LSR L DV ++ +
Sbjct: 993 VAIEAKLSDLQKEAEKLESEHP-----------DQAQAILSR-----LAEISDVWEEMKT 1036
Query: 2791 HVQHLQSACASSHQFQQMSRD---FQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFS 2847
+++ +++ + + QQ RD FQ+WL ++ + S + L E L+ H++
Sbjct: 1037 TLKNREASLGEASKLQQFLRDLDDFQSWL-SRTQTAIASEDMPNTLTEAEKLLTQHENIK 1095
Query: 2848 KTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKES 2907
+ Y+K GE + ++ L+ +L + T W+ +K + R+N L +S
Sbjct: 1096 NEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQS 1155
Query: 2908 --LEKALKYKEQVETLWPWIDKCQNNLE------EIKFCLDPAEGENSIAKLKSLQKEMD 2959
++ L+ +Q E NN E E+ L+ AE +I K + MD
Sbjct: 1156 HAYQQFLRDTKQAEAF-------LNNQEYVLAHTEMPTTLEGAEA--AIKKQEDFMTTMD 1206
Query: 2960 QHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFK 3019
+ + + T L+S I+ + + +KVD + ++ + + + K
Sbjct: 1207 ANEEKINAVVETGRRLVSDGNINSDRIQ-------EKVDSIDDRHRKNRETASELLMRLK 1259
Query: 3020 EFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLA 3079
+ +++ K + C + L I++ + + + ++ + + + LKHQ +A+ +
Sbjct: 1260 DNRDLQKFLQ---DCQELSLWINEKM----LTAQDMSYDEARNLHSKWLKHQAFMAELAS 1312
Query: 3080 QDLVVEASDSKGTSDVLLQVET---IAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIRE 3136
++ + +G + + ET + ++ + L + + S +TK Q + F E
Sbjct: 1313 NKEWLDKIEKEGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRL--FDANKAE 1370
Query: 3137 MFSQ-FAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMM--- 3192
+F+Q A+ D L + ++ K ++ LKK + L + K + +
Sbjct: 1371 LFTQSCADLDKWLHGLES-QIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQ 1429
Query: 3193 ---LATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSI 3249
L+ E S D V KR + + +LL+ R+ + + K + +F +++ I
Sbjct: 1430 AQALSQEGKSTDEVDSKR--LTVQTKFMELLEPLNERKHNLLAS-KEIHQFNRDVED-EI 1485
Query: 3250 LLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAK 3309
L + G +T+ + + QK EI+ Q + D+ Q ++ ++
Sbjct: 1486 LWVGERMPLATSTDHGHNLQTVQLLIKKNQTLQK-EIQGHQPRIDDIFERSQNIVTDSS- 1543
Query: 3310 STSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELV 3369
S S + + L D+ W L ++ +R +L+EA + DA E+ +WM + E +
Sbjct: 1544 SLSAEAIRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEA-EAWMSEQELYM 1602
Query: 3370 ANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQL 3429
+++ E V + +++ ++L++ ++D TV + + + + P + +I +
Sbjct: 1603 MSEEKAKDEQSAV-SMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHP-ESERISMRQ 1660
Query: 3430 SLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQAS 3489
S +D + L + AE R +L+ + Q + ++ L +W+ E + +G
Sbjct: 1661 SKVDKLYAGLKDLAEERRGKLDERHRLF-QLNREVDDLEQWIAEREV-VAGSHELGQDYE 1718
Query: 3490 KLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQ 3549
+ + + D N + V+ + S D + D + ++
Sbjct: 1719 HVTMLQERFREFARDTGNIGQERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLL 1778
Query: 3550 EKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYST-EGLWKQQSELR 3608
E +R+++L A F D E+ + + H KL + +D +T E L + +
Sbjct: 1779 ELIDTRTQIL-AASYELHKFYHDAKEIFGRIQDKHKKLPEELGRDQNTVETLQRMHT--- 1834
Query: 3609 VLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTL 3668
+ DI V Q + L GD+ IQ + + +K + L
Sbjct: 1835 TFEHDIQALGTQVRQLQEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRL 1894
Query: 3669 EQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKA 3728
R S +L W++ V ++ + E K + S ++ L + KA
Sbjct: 1895 VDTGD-KFRFFSMVRDLMLWMEDVIRQIEAQE----KPRDVSSVEL----LMNNHQGIKA 1945
Query: 3729 LLDSLN-------EVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAI 3781
+D+ N E+ +LL + + E EK++ +R ++ D + E + I
Sbjct: 1946 EIDARNDSFTTCIELGKSLLARKHYASEEIKEKLLQLTEKRKEMI-DKWEDRWEWL-RLI 2003
Query: 3782 LRSQQFDQAADAELSWITETEKKLMS 3807
L QF + A +W+ E L S
Sbjct: 2004 LEVHQFSRDASVAEAWLLGQEPYLSS 2029
Score = 104 bits (259), Expect = 3e-21
Identities = 314/1692 (18%), Positives = 646/1692 (38%), Gaps = 220/1692 (13%)
Query: 1223 AAEALVKLYETK--------LCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALED 1274
AAE +L E++ + EEE I +K I + K S V A ED
Sbjct: 614 AAERRARLEESRRLWKFFWEMAEEEGWIREKEKILSSDDYGKDLTS-VMRLLSKHRAFED 672
Query: 1275 ELQKAKAISDEMFKTYKERDLDFDWHKEKADQLV----ERWQNVHVQIDNRLRDLEGIGK 1330
E+ ++ K ++ + + EK + + E+W N+ R + LE
Sbjct: 673 EMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKKRLEEASL 732
Query: 1331 SLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQ--LNQQKMLVSEIEMKQSKM 1388
++ D +D W+ + KI + +TQ + + K + EI + +
Sbjct: 733 LHQFQADA-DDIDAWMLDI----LKIVSSSDVGHDEYSTQSLVKKHKDVAEEIANYRPTL 787
Query: 1389 DECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYT 1448
D + A A+ +SP R R+ + + R R
Sbjct: 788 DTLHEQAS-----------------ALPQEHAESPDVRGRLSGIEERYKEVAELTRLRKQ 830
Query: 1449 ALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGK 1508
AL + Y F+ L +EK + EK ++L+ ++ ++ +
Sbjct: 831 ALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLE--------VIQHRFESLE 882
Query: 1509 PPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLL 1568
P + Q ++ QL + + + DK+ + ++ + V +++
Sbjct: 883 PEMNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQDKL-NTRWSQFRELVDRKKDALLSA 941
Query: 1569 FSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGD 1628
S L+ ++T ++ + K++ E Q+ L G+ L + +L G + + +
Sbjct: 942 LSIQNYHLECNETKSWIREKTKVI-ESTQDLGNDLAGVMAL----QRKLTGMERDLVAIE 996
Query: 1629 GTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAK 1688
+L Q + E+L+ + AQA+ + + +E L + +L E
Sbjct: 997 A--KLSDLQKEAEKLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEAS----- 1049
Query: 1689 IKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSE 1748
K +Q + + L + T E+ + + E+ T+ EN+ + + N ++D +
Sbjct: 1050 -KLQQFLRDLDDFQSWLSRTQTAIASEDMPNT--LTEAEKLLTQHENIKNEIDNYEEDYQ 1106
Query: 1749 RAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVK 1808
+ +++ Q T Q + + D L + + Q +Q + QQ+ +
Sbjct: 1107 KMRDMG-EMVTQGQTDAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDT 1165
Query: 1809 AQHEKIISQHQAVIIATQ------SAQVLLEKQGQYLSP----EEK-------------- 1844
Q E ++ + V+ T+ A+ ++KQ +++ EEK
Sbjct: 1166 KQAEAFLNNQEYVLAHTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSD 1225
Query: 1845 -----EKLQKNMKELKV-HYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQ 1898
+++Q+ + + H + SE M+L + +L+KF D E W+ +E+
Sbjct: 1226 GNINSDRIQEKVDSIDDRHRKNRETASELLMRLKDN--RDLQKFLQDCQELSLWI--NEK 1281
Query: 1899 ELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGK 1958
L + D+ L +K + ++F ++ S+K L I G +++ K
Sbjct: 1282 MLTAQDMSYDEARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQLISE----------K 1331
Query: 1959 VDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACE 2018
+T A V+ KL + L S L D +K + + + L L E
Sbjct: 1332 PETEAV---VKEKLTGLHKMWEVLESTTQTKAQRLFD-ANKAELFTQSCADLDKWLHGLE 1387
Query: 2019 ATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAK 2078
S+ S+ D ++ L++ + L+ Q+ ++ +E+L+ A+ L S
Sbjct: 1388 ---SQIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQAQALSQEGKST---- 1440
Query: 2079 NDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQG 2138
+++ + ++ +L + +NER L + +D DE+L W+G L
Sbjct: 1441 DEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEIL-WVGE-RMPLATST 1498
Query: 2139 QVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLS 2198
N +Q +I KN L+++I G Q I+ + E+ + + + +A +++ ++ DL
Sbjct: 1499 DHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLK 1558
Query: 2199 ARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQ 2258
+ + ++ ++EE + + + +E E + ++E K E S
Sbjct: 1559 QLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSE----EKAKDEQSA 1614
Query: 2259 YMQESTSEFLEH--KKHLEVLHSLLKEISSHGLPSD----KALVLEKTNNLSKKFKEMED 2312
+ LE + + E +H L K +S L +D + + + + K + ++D
Sbjct: 1615 VSMLKKHQILEQAVEDYAETVHQLSK--TSRALVADSHPESERISMRQSKVDKLYAGLKD 1672
Query: 2313 TIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQ 2372
+E++ + + +L V L+ WI E + G+ +LG+ E LQ
Sbjct: 1673 LAEERRGKLDE-RHRLFQLNREVDDLEQWIAER-------EVVAGSHELGQDYEHVTMLQ 1724
Query: 2373 EKWSLKTPEIQKVNNSGISLCN-----LISAVTTPAKAIAAVKSGGAVLNGEGTATNTEE 2427
E++ + + + N LI++ + A IA K G LN E A E
Sbjct: 1725 ERFREFARDTGNIGQERVDTVNHLADELINSGHSDAATIAEWKDG---LN-EAWADLLEL 1780
Query: 2428 FWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMN 2487
+ + ++ H +++ ++DK +L +L + Q E LQ+M+
Sbjct: 1781 IDTRTQILAASYELHKFYHDAKEIFGRIQDKHKKLPEELGRDQNTVET-------LQRMH 1833
Query: 2488 KTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNV--NKVQELKDKLTELLEENPDTPE 2545
T D +A+ TQV Q + A L+ +K +++ + E+LE
Sbjct: 1834 TTFEH--------DIQALGTQVRQLQEDAARLQAAYAGDKADDIQKRENEVLE------- 1878
Query: 2546 APRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVL 2605
WK +L +S R+ +L ++ + F V L W+ E +
Sbjct: 1879 --AWKSLLDACES-----------RRVRLVDTGDKFRFFSMVR-DLMLWM-EDVIRQIEA 1923
Query: 2606 GPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLA 2665
D + + Q + E R + G+ +L+R +KE+L
Sbjct: 1924 QEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARKHYASE---EIKEKLL 1980
Query: 2666 AVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDA 2725
+T+K + + DR +W+ + I++ Q+ D ++ + + P
Sbjct: 1981 QLTEKRKEMIDKWEDRWEWL-RLILEVHQFSR------------DASVAEAWLLGQEP-- 2025
Query: 2726 MNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVE 2785
+++++ Q + + +K IK +A E +A E + E LE +
Sbjct: 2026 ----YLSSREIGQSVDEVEKLIKRHEAF-EKSAATWDERFSALERLTTLE----LLEVRR 2076
Query: 2786 QKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPI-----SAKLDVLESLI 2840
Q+ E + + S + + + Q W DT K EQ + + S ++
Sbjct: 2077 QQEEEERKRRPPSPEPSTKVSEEAESQQQW-DTSKGEQVSQNGLPAEQGSPRVSYRSQTY 2135
Query: 2841 KDHKDFSKTLTA 2852
+++K+F+ TA
Sbjct: 2136 QNYKNFNSRRTA 2147
Score = 95.9 bits (237), Expect = 1e-18
Identities = 277/1494 (18%), Positives = 572/1494 (38%), Gaps = 238/1494 (15%)
Query: 619 LKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHL 678
L+L++ R+ L+ +L Q + +E M ++ D W+DEM+V + ++G L VE L
Sbjct: 501 LELLRARRQRLEMNLGLQKIFQE---MLYIMD---WMDEMKVLVLSQDYGKHLLGVEDLL 554
Query: 679 ENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAE------------KLHRLESQYAK 726
+ H V E + ++ ++ + +A T E ++ +E Y +
Sbjct: 555 QKHTLV-----EADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQE 609
Query: 727 LLNTSRNQERHLDT---LHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAE 783
L + + L+ L F E W+ EKE+ + D+ + T++ R H
Sbjct: 610 LCQLAAERRARLEESRRLWKFFWEMAEEEGWIREKEKILSSDDYGKDLTSVMRLLSKHRA 669
Query: 784 LMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKE 843
E+ + + + + E ++ E H I ++ QW+ + QL ++ ++E
Sbjct: 670 FEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKKRLEE 729
Query: 844 NTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKST 903
+ +F DA + ++ ++ + S D + + LV++ + EE+ Y+ T
Sbjct: 730 ASLLHQFQADADDIDAWMLDILKIVS---SSDVGHDEYSTQSLVKKHKDVAEEIANYRPT 786
Query: 904 IANLMGKAKTIIQ--------------LKPRNSDCPLKTSIPIKAICDYRQIEITIYKDD 949
+ L +A + Q ++ R + T + +A+ D + + D
Sbjct: 787 LDTLHEQASALPQEHAESPDVRGRLSGIEERYKEVAELTRLRKQALQDTLALYKMFSEAD 846
Query: 950 ECVL--------ANNSH-----------RAKWKVISPTGNE-----AMVPSVC----FTV 981
C L NN + +++ + P N A+V + +
Sbjct: 847 ACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQLMHSG 906
Query: 982 PPPNKE---AVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDR-IRASNVASI 1037
P KE D N Q++ ++ ++ ++ S+ ++H NE IR
Sbjct: 907 HPSEKEIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECNETKSWIREKTKVIE 966
Query: 1038 KTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQE-----LL 1092
T G + LQ + L + V + ++ L+KE + + + L
Sbjct: 967 STQDLGNDLAGVMALQRK----LTGMERDLVAIEAKLSDLQKEAEKLESEHPDQAQAILS 1022
Query: 1093 KSAE----REEQEESVYN--LYISEVRNIRLRLENCED--RLIRQIRTPLERDD----LH 1140
+ AE EE + ++ N + E ++ L + +D + + +T + +D L
Sbjct: 1023 RLAEISDVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLSRTQTAIASEDMPNTLT 1082
Query: 1141 ESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQV 1200
E+ +T+ E +K E++ ++D + + E +Q + LR L + N++
Sbjct: 1083 EAEKLLTQHENIKNEIDNYEEDYQKMRD-MGEMVTQGQTDAQYMFLRQRLQALDTGWNEL 1141
Query: 1201 YSM---SSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQ 1257
+ M + + L++T+ AEA + E L E + +TL+
Sbjct: 1142 HKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTE-----------MPTTLEG 1190
Query: 1258 WRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQ 1317
+ + ++ ++ +K A+ + + + +++ D +EK D + +R +
Sbjct: 1191 AEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQEKVDSIDDRHRKNRET 1250
Query: 1318 IDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKML 1377
L L+ + L+ + L WI + T Q+ + ++ L ++ + +
Sbjct: 1251 ASELLMRLKD-NRDLQKFLQDCQELSLWINEKMLT---AQDMSYDEARNLHSKWLKHQAF 1306
Query: 1378 VSEIEMKQSKMDECQKYAEQY-------SATVKDYELQTMTYRAMVDSQQKSPVKRRRMQ 1430
++E+ + +D+ +K Q A VK+ +++S ++ +R
Sbjct: 1307 MAELASNKEWLDKIEKEGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDA 1366
Query: 1431 SSADLIIQEFMDLRTRYTALVTLMTQYIKFAGD--SLKRLEEEEKSLEEEKKEHVEKAKE 1488
+ A+L Q DL ++ + Q + D S+ L ++++ LE + + ++ +E
Sbjct: 1367 NKAELFTQSCADL-DKWLHGLESQIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEE 1425
Query: 1489 LQKWVSNISKTLKDAEKAGK-------------PPFSKQK---ISSEEISTKKEQLSEA- 1531
LQ +S+ K ++ P +++K ++S+EI + +
Sbjct: 1426 LQSQAQALSQEGKSTDEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEI 1485
Query: 1532 ------------------LQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESL 1573
LQT+QL + K+ L+K+++ Q + +F S
Sbjct: 1486 LWVGERMPLATSTDHGHNLQTVQLLIKKN---------QTLQKEIQGHQPRIDDIFERSQ 1536
Query: 1574 KQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGD---GT 1630
+ +S + + +++ +Q L G+ L+ +TE R +EA
Sbjct: 1537 NIVTDSSSLSAEAIRQRLADLKQ------LWGL--LIEETEKRHRRLEEAHRAQQYYFDA 1588
Query: 1631 VELKKYQSKQ------EELQKDMQGSAQALA--EVVKNTENFLKENGEKLSQEDKALIEQ 1682
E + + S+Q EE KD Q + L ++++ E +LS+ +AL+
Sbjct: 1589 AEAEAWMSEQELYMMSEEKAKDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVAD 1648
Query: 1683 KLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLS- 1741
E+ E+++++ + K L + +E K+ +L + ++++L W++
Sbjct: 1649 SHPES----ERISMRQSKVDK-LYAGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAE 1703
Query: 1742 -NVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENL 1800
V S G ++ V T QE E GN+ + VD E +
Sbjct: 1704 REVVAGSHELGQDYEHV-----TMLQE-----RFREFARDTGNIGQERVDTVNHLADELI 1753
Query: 1801 NQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPE-EKEKLQKNMKELKVHYE 1859
N + I + A L++ + Q L+ E K + KE+ +
Sbjct: 1754 NSGHSDAAT----IAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDAKEIFGRIQ 1809
Query: 1860 TALAESEKKMKLTHSL---QEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTK 1916
+K KL L Q +E +T FEH +Q ++ L+ A
Sbjct: 1810 ------DKHKKLPEELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDA--------- 1854
Query: 1917 LKRQKSFSEDVISHKGDLRYITISGNRVLEAAKS----CSKRDGGKVDTSATHR 1966
+ Q +++ D K D I N VLEA KS C R VDT R
Sbjct: 1855 ARLQAAYAGD----KAD--DIQKRENEVLEAWKSLLDACESRRVRLVDTGDKFR 1902
Score = 53.1 bits (126), Expect = 7e-06
Identities = 52/281 (18%), Positives = 116/281 (41%), Gaps = 28/281 (9%)
Query: 633 LLDQNLTEEEINMKF---VQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIE 689
+LD + E++ K+ DLL W+++ + L+ ++ + L V+ L+ N +R +E
Sbjct: 280 VLDNAIETEKMIEKYESLASDLLEWIEQTIIILNNRKFANSLVGVQQQLQAF-NTYRTVE 338
Query: 690 EFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRAT 749
+ ++ + + T K+ + + + + + ++ ER H
Sbjct: 339 KPPKFTEKGNLEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWERLEKAEHERELALR 398
Query: 750 NELIWLNEKEEEEVAYD--------WSERNTNIARKKDY-------------HAELMREL 788
NELI + E+ +D W N + + ++ H + ++
Sbjct: 399 NELIRQEKLEQLARRFDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAATKKHEAIETDI 458
Query: 789 DQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYF 848
EE +++V +A +L EN+ I A + + W ++L+L + Q ++ N
Sbjct: 459 AAYEERVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEMNLGLQ 518
Query: 849 EFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQE 889
+ F + D++ +K + S D + +EDL+Q+
Sbjct: 519 KIFQEMLYIMDWMDEMKVLV---LSQDYGKHLLGVEDLLQK 556
>gi|45439327 periplakin [Homo sapiens]
Length = 1756
Score = 311 bits (798), Expect = 9e-84
Identities = 356/1658 (21%), Positives = 728/1658 (43%), Gaps = 226/1658 (13%)
Query: 645 MKFVQDLLNW---VDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKIS 701
+K V +NW V+E +L+ +G+DLP V+ +E H H ++ L AK
Sbjct: 129 VKEVDPQVNWAALVEEKLDKLNNQSFGTDLPLVDHQVEEHNIFHNEVKAIGPHL--AKDG 186
Query: 702 EIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEE 761
+ + + L+ ++Y KLL S+ +++HL +L +++ R TNEL WL+++ +
Sbjct: 187 DKEQNSELR-----------AKYQKLLAASQARQQHLSSLQDYMQRCTNELYWLDQQAKG 235
Query: 762 EVAYDWSERNTNI-ARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR 820
+ YDWS+RN + +R++ Y + R L+ KEE I + +QLL HP R +IEA+
Sbjct: 236 RMQYDWSDRNLDYPSRRRQYENFINRNLEAKEERINKLHSEGDQLLAAEHPGRNSIEAHM 295
Query: 821 AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSI 880
A+ W L L C E H+K Y +F D K+A + LR + + +KY D
Sbjct: 296 EAVHADWKEYLNLLICEESHLKYMEDYHQFHEDVKDAQELLRKVDSDLNQKYGPDFKDR- 354
Query: 881 HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ 940
+++E L++E ++++ L +Y+ + L + + ++ LK R + PLK IP++A+CD+
Sbjct: 355 YQIELLLRELDDQEKVLDKYEDVVQGLQKRGQQVVPLKYRR-ETPLK-PIPVEALCDFEG 412
Query: 941 IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ 1000
+ I + L N+ + W+++ GN+ + P+VCF +PP + EA+ LA+ + QY+
Sbjct: 413 EQGLISRGYSYTLQKNNGES-WELMDSAGNKLIAPAVCFVIPPTDPEALALADSLGSQYR 471
Query: 1001 NVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFL 1060
+V + K + Y + +KT PG+ S+LQ R
Sbjct: 472 SV----RQKAAGSKRTLQQRYEV-------------LKTENPGD----ASDLQGR----- 505
Query: 1061 EDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLE 1120
Q+ +G D +++ + QE+++ +
Sbjct: 506 ------QLLAGLDKV------------------ASDLDRQEKAITGI------------- 528
Query: 1121 NCEDRLIRQIRTPLERD-DLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAA 1179
+R PLE+ + +S R + + + EL R++ + T + E F
Sbjct: 529 ---------LRPPLEQGRAVQDSAERAKDLKNITNELLRIEPEKTRSTAEGEAFIQALPG 579
Query: 1180 SSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEE 1239
S + P LR+ + + + + +K+ N + K+ Q + L+ +E L +++
Sbjct: 580 SGTTPLLRTRVEDTNRKYEHLLQLLDLAQEKVDVANRLEKSLQQSWELLATHENHLNQDD 639
Query: 1240 AVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDW 1299
V +++ L E+ ++ + +E LQ AK S + ++E D +
Sbjct: 640 TVPESSRVLDSKGQELAAMACELQAQKSLLGEVEQNLQAAKQCSSTLASRFQEHCPDLER 699
Query: 1300 HKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQEN 1359
+ + +L +R+ N+ Q++ R + L+ S K + +H D + Q + +
Sbjct: 700 QEAEVHKLGQRFNNLRQQVERRAQSLQ----SAKAAYEHFHRGHDHVLQFLVSIPSYEPQ 755
Query: 1360 QPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVD-- 1417
+ ++ + T+L QK L+ EI ++ ++ + ++QY VKDYEL+ R+++D
Sbjct: 756 ETDSLSQMETKLKNQKNLLDEIASREQEVQKICANSQQYQQAVKDYELEAEKLRSLLDLE 815
Query: 1418 -SQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTL---MTQYIKFAGDSLKRLEEEEK 1473
+ KR R+QS A + +E L ++T + + Q ++FA + L++ E E
Sbjct: 816 NGRSSHVSKRARLQSPATKVKEEEAALAAKFTEVYAINRQRLQNLEFALNLLRQQPEVEV 875
Query: 1474 SLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQ------ 1527
+ E ++ + E + W I K L + + + ++ K + EEI T + Q
Sbjct: 876 THETLQRNRPDSGVE-EAW--KIRKELDEETERRRQLENEVKSTQEEIWTLRNQGPQESV 932
Query: 1528 -------------LSEALQTIQLFLA--KHGDKMTDEERNELEKQVKTLQE-----SYNL 1567
L E+ Q +Q LA +H +++ EE L+ Q++ L++
Sbjct: 933 VRKEVLKKVPDPVLEESFQQLQRTLAEEQHKNQLLQEELEALQLQLRALEQETRDGGQEY 992
Query: 1568 LFSESLK-QLQESQTSGDVKVEEKIVAERQQE---------YKEKLQGICDLLTQTENRL 1617
+ E L+ + +Q +++ E++ A R+Q+ ++++ + + ++ + ++
Sbjct: 993 VVKEVLRIEPDRAQADEVLQLREELEALRRQKGAREAEVLLLQQRVAALAEEKSRAQEKV 1052
Query: 1618 IGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDK 1677
+ + D +E +YQ QE+ Q+ Q L E + +FL++ ++L +E +
Sbjct: 1053 TEKEVVKLQNDPQLE-AEYQQLQEDHQRQDQ-----LREKQEEELSFLQDKLKRLEKE-R 1105
Query: 1678 ALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLL 1737
A+ E K+ ++ LK E+ ++ V+ ++ ++ A + + KT++ +
Sbjct: 1106 AMAEGKITVKEV------LKVEKD-AATEREVSDLTRQYEDEAAKARASQREKTELLRKI 1158
Query: 1738 DWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQ 1797
W + E A K V+++ D K+ E + N L + + + +
Sbjct: 1159 -WA----LEEENA----KVVVQEKVREIVRPDPKA---ESEVANLRLELVEQERKYRGAE 1206
Query: 1798 ENLNQQYQKVKAQHEK---IISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQK----N 1850
E L +++A + + + + +EK+ Q L E +K + +
Sbjct: 1207 EQLRSYQSELEALRRRGPQVEVKEVTKEVIKYKTDPEMEKELQRLREEIVDKTRLIERCD 1266
Query: 1851 MKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDI 1910
++ ++ E + K T + +E+ +F D Q+++E+ +L A +
Sbjct: 1267 LEIYQLKKEIQALKDTKPQVQTKEVVQEILQFQED--------PQTKEEVASLRAKLSEE 1318
Query: 1911 NGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQ- 1969
L+R+++ E+ I+ K + + V + + G + + SA +
Sbjct: 1319 QKKQVDLERERASQEEQIARKEE-ELSRVKERVVQQEVVRYEEEPGLRAEASAFAESIDV 1377
Query: 1970 --RKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGL------LAGLQACEATA 2021
R++D R L + L L++L + Q +A + LA L+ EA A
Sbjct: 1378 ELRQIDKLRAELRRLQRRRTELERQLEELERERQARREAEREVQRLQQRLAALEQEEAEA 1437
Query: 2022 SKHLSEPIAV----DPKN------LQRQLEE----TKALQGQISS---QQVAVEKLKKTA 2064
+ ++ V DP+ L+ QLEE + L+G++ + + A+EK +
Sbjct: 1438 REKVTHTQKVVLQQDPQQAREHALLRLQLEEEQHRRQLLEGELETLRRKLAALEKAEVKE 1497
Query: 2065 EVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEML 2124
+V+L S+ K D ++ + + E+ S+S E L + ++R ++ L E+
Sbjct: 1498 KVVLSE--SVQVEKGDTEQEIQRLKSSLEEESRSKRE----LDVEVSR---LEARLSEL- 1547
Query: 2125 DWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDP 2184
N +SS KE + + LQ + +N+ LE QS IN + + T
Sbjct: 1548 -EFHNSKSS-KELDFLREENHKLQ-LERQNLQLE--TRRLQSEINMAATETRDLRNMTVA 1602
Query: 2185 STASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKV 2222
+ ++ +++ L + K+ +++EL+ ++
Sbjct: 1603 DSGTNHDSRLWSLERELDDLKRLSKDKDLEIDELQKRL 1640
Score = 84.0 bits (206), Expect = 4e-15
Identities = 326/1767 (18%), Positives = 699/1767 (39%), Gaps = 272/1767 (15%)
Query: 1630 TVELKKYQSKQ-EELQKDMQGSAQALAEVVKNTENFLKENGEKLSQ----EDKALIEQKL 1684
TV+ + +K+ EL + +Q +A + + + +TE ++ + +L + E + + QK+
Sbjct: 16 TVQTRSISNKELSELIEQLQKNADQVEKNIVDTEAKMQSDLARLQEGRQPEHRDVTLQKV 75
Query: 1685 NEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAA--VKQLEESKTKIENLLDWLSN 1742
+++ L E D + +K + A ++QL+E T +
Sbjct: 76 LDSEKLLYVL---------EADAAIAKHMKHPQGDMIAEDIRQLKERVTNLRG------- 119
Query: 1743 VDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEE--DEVNGNLLETD---VDGQVGTTQ 1797
KHKQ+ +A+ EE D++N TD VD QV
Sbjct: 120 ----------KHKQIYRLAVKEVDPQVNWAALVEEKLDKLNNQSFGTDLPLVDHQV---- 165
Query: 1798 ENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVH 1857
E N + +VKA I H A K+ ++ EL+
Sbjct: 166 EEHNIFHNEVKA-----IGPHLA-----------------------KDGDKEQNSELRAK 197
Query: 1858 YETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKL 1917
Y+ LA S+ + + SLQ+ +++ T +WL Q + + +++ +
Sbjct: 198 YQKLLAASQARQQHLSSLQDYMQRC----TNELYWLDQQAKGRMQYDWSDRNLDYPSRRR 253
Query: 1918 KRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATD 1977
+ + + ++ + + + + G+++L A R+ + A H + + L+
Sbjct: 254 QYENFINRNLEAKEERINKLHSEGDQLLAAEHP--GRNSIEAHMEAVHADWKEYLNLLI- 310
Query: 1978 RFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQ 2037
C ++LK + D +Q +ED Q L++ D K+ +
Sbjct: 311 --------CEE--SHLKYMEDYHQFHEDVK-----DAQELLRKVDSDLNQKYGPDFKD-R 354
Query: 2038 RQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSK 2097
Q+E L ++ Q+ ++K + + L ++P K + L I +
Sbjct: 355 YQIE---LLLRELDDQEKVLDKYEDVVQGLQKRGQQVVPLKYRRETPLKPI-----PVEA 406
Query: 2098 SVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQV----PLNSTAL---QDI 2150
+ E+ I+ S ++Q E + M + + L P + AL +
Sbjct: 407 LCDFEGEQGLISRGYSYTLQKNNGESWELMDSAGNKLIAPAVCFVIPPTDPEALALADSL 466
Query: 2151 ISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAK--MKDLSARFSEASHKH 2208
S+ + Q AG + ++ E +K T +P AS LQ + + L S+ +
Sbjct: 467 GSQYRSVRQKAAGSKRTLQQRYEVLK----TENPGDASDLQGRQLLAGLDKVASDLDRQE 522
Query: 2209 K----------ETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVD-----VPGKDV 2253
K E +++ + + +N++ +L KT++ E + +PG
Sbjct: 523 KAITGILRPPLEQGRAVQDSAERAKDLKNITNELLRIEPEKTRSTAEGEAFIQALPGSGT 582
Query: 2254 TELSQYMQESTSEFLEHKKHLEVLHSLLKEISSH---GLPSDKALVLEKTNNLSKKFKEM 2310
T L + E T+ EH L L ++++ L L+ N+L++
Sbjct: 583 TPLLRTRVEDTNRKYEHLLQLLDLAQEKVDVANRLEKSLQQSWELLATHENHLNQ----- 637
Query: 2311 EDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKK 2370
+DT+ E + S ++L A +++ KS + E ++L + + +
Sbjct: 638 DDTVPESSRVLDSKGQELAAMACELQAQKSLLGEVE------------QNLQAAKQCSST 685
Query: 2371 LQEKWSLKTPEIQK----VNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTE 2426
L ++ P++++ V+ G NL V A+++ + K+ E
Sbjct: 686 LASRFQEHCPDLERQEAEVHKLGQRFNNLRQQVERRAQSLQSAKAA------------YE 733
Query: 2427 EFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKM 2486
F ++G + + + I YE D ++++ TKL + +E ++ Q +QK+
Sbjct: 734 HF--HRGHDHVLQFLVSIP-SYEPQET---DSLSQMETKLKNQKNLLDEIASREQEVQKI 787
Query: 2487 NKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEA 2546
+ ++QQ + EA K + E +V+K L+ T++ EE + A
Sbjct: 788 CANSQQYQQAVKDYELEAEK--LRSLLDLENGRSSHVSKRARLQSPATKVKEE--EAALA 843
Query: 2547 PRWKQMLTEIDSKWQELN-QLTIDRQQKLEESSNNLTQFQTVEAQLKQ-WLVEKELMVSV 2604
++ ++ + Q L L + RQQ E ++ Q ++ +++ W + KEL
Sbjct: 844 AKFTEVYAINRQRLQNLEFALNLLRQQPEVEVTHETLQRNRPDSGVEEAWKIRKELDEET 903
Query: 2605 LGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQL 2664
++ + +TQ +E T + Q Q + + +L + DP L ++
Sbjct: 904 ERRRQLENEVKSTQ--------EEIWTLRNQGPQESVVRKEVLKKV-PDPVLEESFQQLQ 954
Query: 2665 AAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPD 2724
+ ++ + + Q +++ Q Q LR+L + D + + PD
Sbjct: 955 RTLAEE---------QHKNQLLQEELEALQLQ--LRALEQETRDGGQEYVVKEVLRIEPD 1003
Query: 2725 AMNQQLETAQKMKQEIQQEKKQIKVAQA---LCEDLSALVKEEYLKAELSRQLEGILKSF 2781
Q + ++++E++ ++Q +A L + A + EE +A+ + ++K
Sbjct: 1004 --RAQADEVLQLREELEALRRQKGAREAEVLLLQQRVAALAEEKSRAQEKVTEKEVVKLQ 1061
Query: 2782 KDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIK 2841
D + +AE Q LQ Q ++ + ++L K + K ++ ++ ++K
Sbjct: 1062 NDPQLEAE--YQQLQEDHQRQDQLREKQEEELSFLQDKLKRLEKERAMAEGKITVKEVLK 1119
Query: 2842 DHKDFS--KTLTAQSHMYEKTIA-------EGENLLLKTQGSE----KAALQLQLNTI-- 2886
KD + + ++ + YE A E LL K E K +Q ++ I
Sbjct: 1120 VEKDAATEREVSDLTRQYEDEAAKARASQREKTELLRKIWALEEENAKVVVQEKVREIVR 1179
Query: 2887 ---KTNWDTFNKQVK--ERENKLKESLEKALKYKEQVETL---WPWIDKCQNNLEEIKFC 2938
K + N +++ E+E K + + E+ Y+ ++E L P ++ + E IK+
Sbjct: 1180 PDPKAESEVANLRLELVEQERKYRGAEEQLRSYQSELEALRRRGPQVEVKEVTKEVIKYK 1239
Query: 2939 LDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEV-VTDENKSLIQKV 2997
DP + +L+ L++E+ ++E + L + ++ KE+ + K +Q
Sbjct: 1240 TDPEMEK----ELQRLREEIVDKTRLIERCD------LEIYQLKKEIQALKDTKPQVQTK 1289
Query: 2998 DMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTM 3057
++V E L ++ + + ++S+E K+Q+ +E+ + + A + L+
Sbjct: 1290 EVVQEILQFQE-DPQTKEEVASLRAKLSEEQKKQVDLERERASQEEQI---ARKEEELSR 1345
Query: 3058 LQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKC 3117
++ + + ++++ + R E+ D + L Q++ + E L ++ E
Sbjct: 1346 VKERVVQQEVVRYEEEPGLRAEASAFAESIDVE-----LRQIDKLRAELRRLQRRRTE-- 1398
Query: 3118 SFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEA 3177
LE +L+ + + RE + L ++ +AE +K T K L++
Sbjct: 1399 --LERQLEELERERQARREAEREVQRLQQRLAALEQ--EEAEAREKVTHTQKVVLQQ--- 1451
Query: 3178 LMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRL 3237
A + + L EE ++ +LE L ++ L++A+ +E+ V ++
Sbjct: 1452 ---DPQQAREHALLRLQLEEEQHRRQLLEGELETLRRKL-AALEKAEVKEKVVLSESVQV 1507
Query: 3238 EEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKV----------FQKEEIE 3287
E+ ++ +E L EE S+ + +E + +L+ + F +EE
Sbjct: 1508 EKGDTE-QEIQRLKSSLEEESRSKRELDVEVSRLEARLSELEFHNSKSSKELDFLREENH 1566
Query: 3288 PLQGKQQDVNWLGQGLIQSAAKSTSTQ 3314
LQ ++Q++ L +QS +T+
Sbjct: 1567 KLQLERQNLQ-LETRRLQSEINMAATE 1592
Score = 80.5 bits (197), Expect = 4e-14
Identities = 170/848 (20%), Positives = 339/848 (39%), Gaps = 150/848 (17%)
Query: 3300 GQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLL 3359
G+ IQ+ S +T L ++D N +++ L Q QE + R + +L+
Sbjct: 570 GEAFIQALPGSGTTPLLRTRVEDTNRKYEHL----LQLLDLAQEKVDVANRLEKSLQQ-- 623
Query: 3360 SW-MVDTEELVANQK---PPSA--------EFKVVKAQIQEQKLLQRLLDDRKSTVEVIK 3407
SW ++ T E NQ P S+ E + ++Q QK LL + + ++ K
Sbjct: 624 SWELLATHENHLNQDDTVPESSRVLDSKGQELAAMACELQAQK---SLLGEVEQNLQAAK 680
Query: 3408 REGEKIATTAEP--ADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLE 3465
+ +A+ + D + ++ L R+ L + E R + L+ + FH +
Sbjct: 681 QCSSTLASRFQEHCPDLERQEAEVHKLGQRFNNLRQQVERRAQSLQSAKAAYEHFHRGHD 740
Query: 3466 PLNEWLTTIEKRLVNCEPIGTQA-SKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLK- 3523
+ ++L +I + EP T + S++E ++ K L D+I + + + + + Q +
Sbjct: 741 HVLQFLVSIP----SYEPQETDSLSQMETKLKNQKNLLDEIASREQEVQKICANSQQYQQ 796
Query: 3524 -VLSSREDKDMVQSKLDFSQVWYIEIQEKSH-SRSELLQQALCNAKIFGEDEVELMNWLN 3581
V + + ++S LD +E SH S+ LQ K E+E L
Sbjct: 797 AVKDYELEAEKLRSLLD------LENGRSSHVSKRARLQSPATKVK---EEEAALAAKFT 847
Query: 3582 EVHDKLSKLSVQDYSTE-GLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEV 3640
EV+ +++ +Q+ L +QQ E+ V E + + + +G+E
Sbjct: 848 EVY-AINRQRLQNLEFALNLLRQQPEVEVTHETLQRNRPD------SGVE---------- 890
Query: 3641 LIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDK------VEV 3694
+ K+ ++ + E+ QL + ST EE+ T ++ V
Sbjct: 891 ---------------EAWKIRKELDEETERRRQLENEVKSTQEEIWTLRNQGPQESVVRK 935
Query: 3695 ELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEK 3754
E+L + E Q Q + L +E N+ L + L E L + R+G ++
Sbjct: 936 EVLKKVPDPVLEESFQQLQ---RTLAEEQHKNQLLQEEL-EALQLQLRALEQETRDGGQE 991
Query: 3755 MVAEDNERY---RLVSDTITQKVEEIDAA----------ILRSQQFDQAADAELSWITE- 3800
V ++ R R +D + Q EE++A +L QQ A E S E
Sbjct: 992 YVVKEVLRIEPDRAQADEVLQLREELEALRRQKGAREAEVLLLQQRVAALAEEKSRAQEK 1051
Query: 3801 -TEKKLMSL-GDIRLE------------QDQTSAQLQVQKTFTMEILRHKDIIDDLVKSG 3846
TEK+++ L D +LE QDQ + + + +F + L+ + + +
Sbjct: 1052 VTEKEVVKLQNDPQLEAEYQQLQEDHQRQDQLREKQEEELSFLQDKLKRLEKERAMAEGK 1111
Query: 3847 HKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPW 3906
+ E+ + ++++ + + Y+ + R Q E+ + L+ + W EE
Sbjct: 1112 ITVKEVLKVEKDAATEREVSDLTRQYED--EAAKARASQREKTE-LLRKIWALEEENAKV 1168
Query: 3907 LTETQSIISQLPAPALEYET------LRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLE 3960
+ + + P P E E L +Q+ ++R E + ++ ++ + + GPQ
Sbjct: 1169 VVQEKVREIVRPDPKAESEVANLRLELVEQERKYRGAEEQLRSYQSELEALRRRGPQ--- 1225
Query: 3961 LSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVE 4020
++ K V + + + +++K L E I T+ ++ D + L++ ++
Sbjct: 1226 --------VEVKEVTKEVIKYKTDPEMEKELQRLREEIVDKTRLIERCDLEIYQLKKEIQ 1277
Query: 4021 RLR-------------------QPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQ 4061
L+ + P EV ++ ++SE + VD+E+ + E
Sbjct: 1278 ALKDTKPQVQTKEVVQEILQFQEDPQTKEEVASLRAKLSEEQKKQVDLERERASQEEQIA 1337
Query: 4062 RGEEMIAR 4069
R EE ++R
Sbjct: 1338 RKEEELSR 1345
Score = 71.2 bits (173), Expect = 3e-11
Identities = 264/1303 (20%), Positives = 495/1303 (37%), Gaps = 209/1303 (16%)
Query: 3954 TGPQLLELSPGEGF---SIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQ 4010
T P+ L L+ G S+++K + Q + +V K D + Q Q +D+
Sbjct: 455 TDPEALALADSLGSQYRSVRQKAAGSKRTLQQ-RYEVLKTENPGDASDLQGRQLLAGLDK 513
Query: 4011 ILESLER----IVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEM 4066
+ L+R I LR P V+ E+ + KN++ ++ +++P GE
Sbjct: 514 VASDLDRQEKAITGILRPPLEQGRAVQDSAERAKDLKNITNELLRIEPEKTRSTAEGEAF 573
Query: 4067 IARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIV 4126
I G+ + ++ +++ +E++ L++ + K +DV EK L+
Sbjct: 574 IQALPGSG---TTPLLRTRVEDTNRKYEHLLQLLDLAQEK-VDVANRLEKSLQQSWELLA 629
Query: 4127 TIKD-------TQDFIRDLEDPGIDPSVVKQQQEAAETIREEID-GLQEELDIVINLGSE 4178
T ++ + R L+ G + + + + +A +++ E++ LQ L S
Sbjct: 630 THENHLNQDDTVPESSRVLDSKGQELAAMACELQAQKSLLGEVEQNLQAAKQCSSTLASR 689
Query: 4179 LIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDG----LQAVF 4234
C PD + + +L +++L + + R L+ A A + G LQ +
Sbjct: 690 FQEHC--PDLERQEAEVHKLGQRFNNLRQQVERRAQSLQSAKAAYEHFHRGHDHVLQFLV 747
Query: 4235 DWVDIAGGKLASMSPIGTDLETVKQQIEELKQ---------FKSEAYQQ-----QIEMER 4280
+ S+S + T L+ K ++E+ S+ YQQ ++E E+
Sbjct: 748 SIPSYEPQETDSLSQMETKLKNQKNLLDEIASREQEVQKICANSQQYQQAVKDYELEAEK 807
Query: 4281 LNHQAELLLKKVTEESDKHTVQDPLMELK-----LIWDSLEERIINRQ--HKLEGALLAL 4333
L +L + + S + +Q P ++K L E INRQ LE AL L
Sbjct: 808 LRSLLDLENGRSSHVSKRARLQSPATKVKEEEAALAAKFTEVYAINRQRLQNLEFALNLL 867
Query: 4334 GQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEI------ELAKHHVLQNDVLAHQST 4387
Q + T L +P G +A +I E + L+N+V + Q
Sbjct: 868 RQQPE--------VEVTHETLQRNRPDSGVEEAWKIRKELDEETERRRQLENEVKSTQEE 919
Query: 4388 VEAVNKAGNDLIESSAGEEASNL--QNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGF 4445
+ + G ES +E LE Q+ Q L + EQ K QL
Sbjct: 920 IWTLRNQGPQ--ESVVRKEVLKKVPDPVLEESFQQLQRTLAE-EQHKNQL---------L 967
Query: 4446 HGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEA---KEETYKSLMQ 4502
E+E LQ L E+ GG KE L + + A E +EE Q
Sbjct: 968 QEELEALQLQLRALEQETRD----GGQEYVVKEVLRIEPDRAQADEVLQLREELEALRRQ 1023
Query: 4503 KGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERK-TKLEEALNLAMEFHNSLQDF 4561
KG + ++ + Q + L E+ + K+ E++ KL+ L E+ +D
Sbjct: 1024 KGAR------EAEVLLLQQRVAALAEEKSRAQEKVTEKEVVKLQNDPQLEAEYQQLQEDH 1077
Query: 4562 INWLTQAEQTLNVASRPSL-ILDTVLFQID------EHKVFANEV-NSHREQIIELDKTG 4613
Q + L L L L +++ E K+ EV ++ E + +
Sbjct: 1078 -----QRQDQLREKQEEELSFLQDKLKRLEKERAMAEGKITVKEVLKVEKDAATEREVSD 1132
Query: 4614 THLKY--------FSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHE 4665
+Y SQ++ L++ + + + VVQ V + R K E
Sbjct: 1133 LTRQYEDEAAKARASQREKTELLRKIWALEEENAKVVVQEKVR-----EIVRPDPKAESE 1187
Query: 4666 AWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSL 4725
+ +E +E+ K +E QL ++ ++L + + T +
Sbjct: 1188 VANLRLELVEQERKYRGAE-----------EQLRSYQSELEALRRRGPQVEVKEVTKEVI 1236
Query: 4726 KEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLY 4785
K KT + +++ L LR+ + V++ +E L Q +QAL D
Sbjct: 1237 KYKT-----DPEMEKELQRLRE-------EIVDKTRLIERCDLEIYQLKKEIQALKDTKP 1284
Query: 4786 RVEPQLAEDQPVHGDID-LVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSS 4844
+V+ + + + D + + +A E K+ ++ + S E I ++ S
Sbjct: 1285 QVQTKEVVQEILQFQEDPQTKEEVASLRAKLSEEQKKQVDLERERASQEEQIARKEEELS 1344
Query: 4845 WVKVQ-MQELSTRWETVCALSISKQT---RLEAALRQAEEFHSVVHALLEWLAEAEQTLR 4900
VK + +Q+ R+E L ++ LRQ ++ + + L E E+ L
Sbjct: 1345 RVKERVVQQEVVRYEEEPGLRAEASAFAESIDVELRQIDKLRAELRRLQRRRTELERQLE 1404
Query: 4901 FHGVLPDDEDALRTL---IDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKH 4957
L + A R + + ++ + LE++ AE + T T + D +H
Sbjct: 1405 ---ELERERQARREAEREVQRLQQRLAALEQEEAEAREKVT--HTQKVVLQQDPQQAREH 1459
Query: 4958 WITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIP 5017
++R + EE +QH+++L L + E L LA L+ AE K+K V+
Sbjct: 1460 --ALLRLQLEE-----EQHRRQL------LEGELETLRRKLAALEKAEV----KEKVVLS 1502
Query: 5018 QEIEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKR 5077
+ ++ E +E+ R + +++ +++ + + S L++ + L+ + +
Sbjct: 1503 ESVQ------VEKGDTEQEIQRLKSSLEEESRSKRELDVEVSRLEARLSELEFHNSKSSK 1556
Query: 5078 FPASSLYPSGSQTQIETKNPRVNLLVSKWQQVWLLALERRR---KLNDALDRLEELREF- 5133
L + Q+E +N L LE RR ++N A +LR
Sbjct: 1557 -ELDFLREENHKLQLERQN---------------LQLETRRLQSEINMAATETRDLRNMT 1600
Query: 5134 -----ANFDFDIWRKKYMRWMNHKKSRVMDFFRRIDKDQDGKI 5171
N D +W R +D +R+ KD+D +I
Sbjct: 1601 VADSGTNHDSRLW----------SLERELDDLKRLSKDKDLEI 1633
Score = 66.6 bits (161), Expect = 6e-10
Identities = 250/1287 (19%), Positives = 495/1287 (38%), Gaps = 203/1287 (15%)
Query: 2499 PTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDS 2558
PTD EA+ + + ++ + L+ + L ENP + +Q+L +D
Sbjct: 454 PTDPEALALADSLGSQYRSVRQKAAGSKRTLQQRYEVLKTENPGDASDLQGRQLLAGLDK 513
Query: 2559 KWQELNQ-----------------LTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELM 2601
+L++ D ++ ++ N + +E + + E E
Sbjct: 514 VASDLDRQEKAITGILRPPLEQGRAVQDSAERAKDLKNITNELLRIEPEKTRSTAEGEAF 573
Query: 2602 VSVLGPLSIDP----NMLNTQRQQVQIL-LQEFATRK-----------PQYEQLTAAGQG 2645
+ L P + +T R+ +L L + A K Q +L A +
Sbjct: 574 IQALPGSGTTPLLRTRVEDTNRKYEHLLQLLDLAQEKVDVANRLEKSLQQSWELLATHEN 633
Query: 2646 ILSRPGEDPSLRGIVK---EQLAAVT---QKWDSLTGQLSDRCDWIDQAIVKSTQYQSLL 2699
L++ P ++ ++LAA+ Q SL G+ ++Q + + Q S L
Sbjct: 634 HLNQDDTVPESSRVLDSKGQELAAMACELQAQKSLLGE-------VEQNLQAAKQCSSTL 686
Query: 2700 RS-LSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQI-KVAQALCEDL 2757
S + DL+ + + + + + QQ+E + Q + + + + + L
Sbjct: 687 ASRFQEHCPDLERQEAEVHKLGQRFNNLRQQVERRAQSLQSAKAAYEHFHRGHDHVLQFL 746
Query: 2758 SALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLD 2817
++ E + + Q+E LK+ K++ + + Q +Q CA+S Q+QQ +D++ L+
Sbjct: 747 VSIPSYEPQETDSLSQMETKLKNQKNLLDEIASREQEVQKICANSQQYQQAVKDYE--LE 804
Query: 2818 TKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKA 2877
+K L SL+ S SH+ ++ + +K E+A
Sbjct: 805 AEK---------------LRSLLDLENGRS------SHVSKRARLQSPATKVK---EEEA 840
Query: 2878 ALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKF 2937
AL + + N+Q ++LE AL Q Q +E
Sbjct: 841 ALAAKFTEVY----AINRQ-------RLQNLEFALNLLRQ-----------QPEVEVTHE 878
Query: 2938 CLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDEN------- 2990
L ++ + + ++KE+D+ L N S +E+ T N
Sbjct: 879 TLQRNRPDSGVEEAWKIRKELDEETERRRQLENEVKS------TQEEIWTLRNQGPQESV 932
Query: 2991 --KSLIQKV-DMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGS 3047
K +++KV D V E+ + L+ + + ++ +E LQ L+ G
Sbjct: 933 VRKEVLKKVPDPVLEESFQQ---LQRTLAEEQHKNQLLQEELEALQLQLRALEQETRDGG 989
Query: 3048 QAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDL-VVEASDSKGTSDVLL---QVETIA 3103
Q Y K + ++ + Q D +L ++L + ++VLL +V +A
Sbjct: 990 QEYVVKEVLRIEPD-------RAQADEVLQLREELEALRRQKGAREAEVLLLQQRVAALA 1042
Query: 3104 QEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQK 3163
+E S ++V EK KLQ + + Q E D + +K
Sbjct: 1043 EEKSRAQEKVTEK---EVVKLQN----DPQLEAEYQQLQEDHQRQDQLR---------EK 1086
Query: 3164 QKETIKAFLKKLEALMASNDNANK--TCKMMLATEETSPDLVGIKRDLEALSKQCNKLLD 3221
Q+E + KL+ L A T K +L E+ + +R++ L++Q +
Sbjct: 1087 QEEELSFLQDKLKRLEKERAMAEGKITVKEVLKVEKDA----ATEREVSDLTRQYED--E 1140
Query: 3222 RAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVF 3281
A+AR Q E T + L + ++ +E + ++ + + E + E+E N +L + +
Sbjct: 1141 AAKARASQREKT-ELLRKIWALEEENAKVVVQEKVREIVRPDPKAESEVANLRLELVEQE 1199
Query: 3282 QKEE--IEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLD-DVNARWKTLNKKVAQRA 3338
+K E L+ Q ++ L + Q K + + +++ D ++ + L +++ +
Sbjct: 1200 RKYRGAEEQLRSYQSELEALRRRGPQVEVKEVTKEVIKYKTDPEMEKELQRLREEIVDKT 1259
Query: 3339 AQLQEALLHCGRFQDALESLLSW--MVDTEELVAN----QKPPSAEFKVVKAQI---QEQ 3389
++ L + + +++L V T+E+V Q+ P + +V + +EQ
Sbjct: 1260 RLIERCDLEIYQLKKEIQALKDTKPQVQTKEVVQEILQFQEDPQTKEEVASLRAKLSEEQ 1319
Query: 3390 KLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKI-----------------------L 3426
K L +R S E I R+ E+++ E + ++ L
Sbjct: 1320 KKQVDLERERASQEEQIARKEEELSRVKERVVQQEVVRYEEEPGLRAEASAFAESIDVEL 1379
Query: 3427 KQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHET---LEPLNEWLTTIEKRLVNCEP 3483
+Q+ L + L + RQLE + Q E ++ L + L +E+
Sbjct: 1380 RQIDKLRAELRRLQRRRTELERQLEELERERQARREAEREVQRLQQRLAALEQEEAEARE 1439
Query: 3484 IGTQASKL----EEQIAQHKALEDDIINHNKHLHQAVSIG-QSLKVLSSREDKDMVQSKL 3538
T K+ + Q A+ AL + +H Q + ++L+ + +K V+ K+
Sbjct: 1440 KVTHTQKVVLQQDPQQAREHALLRLQLEEEQHRRQLLEGELETLRRKLAALEKAEVKEKV 1499
Query: 3539 DFSQVWYIE----IQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQ- 3593
S+ +E QE +S L +++ ++ E L L+E+ SK S +
Sbjct: 1500 VLSESVQVEKGDTEQEIQRLKSSLEEESRSKRELDVEVS-RLEARLSELEFHNSKSSKEL 1558
Query: 3594 DYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKAR 3653
D+ E K Q E + LQ + + ++ A +L T D +L +++
Sbjct: 1559 DFLREENHKLQLERQNLQLETRRLQSEINMAATETRDLRNMTVADSGTNHDSRLWSLERE 1618
Query: 3654 YKDITKLSTDVAKTLEQALQLARRLHS 3680
D+ +LS D K LE +L +RL S
Sbjct: 1619 LDDLKRLSKD--KDLE-IDELQKRLGS 1642
Score = 64.3 bits (155), Expect = 3e-09
Identities = 213/1162 (18%), Positives = 459/1162 (39%), Gaps = 155/1162 (13%)
Query: 3642 IIQDKLEAIKARYK------DITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVE 3695
+++ ++E +Y+ D+ + DVA LE++LQ + L +THE D V
Sbjct: 585 LLRTRVEDTNRKYEHLLQLLDLAQEKVDVANRLEKSLQQSWELLATHENHLNQDDTVPES 644
Query: 3696 LLSYETQVLKGEE----ASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREG 3751
++ KG+E A + Q + L + +N +A + ++S E P R+
Sbjct: 645 SRVLDS---KGQELAAMACELQAQKSLLGEVEQNLQAAKQCSSTLASRFQEHCPDLERQ- 700
Query: 3752 LEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDI 3811
E V + +R+ + + ++ + + +A + F + D L + L+S+
Sbjct: 701 -EAEVHKLGQRFNNLRQQVERRAQSLQSAKAAYEHFHRGHDHVLQF-------LVSIPSY 752
Query: 3812 RLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEK-QSMKKKLDKVLK 3870
++ + +Q++ ++ K+++D++ ++ C+ ++ Q K + +
Sbjct: 753 EPQETDSLSQMET------KLKNQKNLLDEIASREQEVQKICANSQQYQQAVKDYELEAE 806
Query: 3871 NYDTICQINSERYLQLE---RAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYE-T 3926
++ + + R + R QS + E L TE +I Q LE+
Sbjct: 807 KLRSLLDLENGRSSHVSKRARLQSPATKVKEEEAALAAKFTEVYAINRQ-RLQNLEFALN 865
Query: 3927 LRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKED 3986
L +QQ E E + ++P + E + I+++ Q++ +
Sbjct: 866 LLRQQPEVEVTHETLQRNRP-------------DSGVEEAWKIRKELDEETERRRQLENE 912
Query: 3987 VKKRAVALDEAISQSTQFHDKIDQILESL-ERIVERLRQPPSISAEVEKIKEQISENKNV 4045
VK + +Q Q ++L+ + + ++E Q + E+ K Q+ + +
Sbjct: 913 VKSTQEEIWTLRNQGPQESVVRKEVLKKVPDPVLEESFQQLQRTLAEEQHKNQLLQEELE 972
Query: 4046 SVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREA 4105
++ ++ L+ L + + G+E + + + + + + + D+++ + E + L ++ A
Sbjct: 973 ALQLQ-LRALEQETRDGGQEYVVK-----EVLRIEPDRAQADEVLQLREELEALRRQKGA 1026
Query: 4106 KLLDVMELAEKF--WCDHMSLIVTIKDTQDFIRDLEDPGIDPSVV------KQQQEAAET 4157
+ +V+ L ++ + S ++ ++ DP ++ ++Q + E
Sbjct: 1027 REAEVLLLQQRVAALAEEKSRAQEKVTEKEVVKLQNDPQLEAEYQQLQEDHQRQDQLREK 1086
Query: 4158 IREEIDGLQEELDIVINLGSELIAACG----------EPDKPIVKKSIDELNSAWDSLNK 4207
EE+ LQ++L L E A G E D ++ D D K
Sbjct: 1087 QEEELSFLQDKLK---RLEKERAMAEGKITVKEVLKVEKDAATEREVSDLTRQYEDEAAK 1143
Query: 4208 AWKDRIDKLE--------EAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQ 4259
A + +K E E A V Q+ ++ + A ++A++ LE V+Q
Sbjct: 1144 ARASQREKTELLRKIWALEEENAKVVVQEKVREIVRPDPKAESEVANLR-----LELVEQ 1198
Query: 4260 QIEELKQFKSEAYQQQIEMERLNHQA-ELLLKKVTEESDKHTVQDPLMELKLIWDSLEER 4318
+ + + + + Q E+E L + ++ +K+VT+E K+ DP ME +L L E
Sbjct: 1199 E-RKYRGAEEQLRSYQSELEALRRRGPQVEVKEVTKEVIKYKT-DPEMEKEL--QRLREE 1254
Query: 4319 IINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIE--IELAKHHV 4376
I+++ +E L + Q + + L + KP + ++ ++ +
Sbjct: 1255 IVDKTRLIERCDLEIYQLKKEIQ-----------ALKDTKPQVQTKEVVQEILQFQEDPQ 1303
Query: 4377 LQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQ-- 4434
+ +V + ++ + K DL A +E + K E L++ + V+++ R ++
Sbjct: 1304 TKEEVASLRAKLSEEQKKQVDLERERASQE-EQIARKEEELSRVKERVVQQEVVRYEEEP 1362
Query: 4435 ------------LDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNV 4482
+D LRQ E+ LQ+ T+ ER L + A+ ++
Sbjct: 1363 GLRAEASAFAESIDVELRQIDKLRAELRRLQRRRTELERQLEELERERQARREAEREVQR 1422
Query: 4483 HMEVCAAFEAKE--------ETYKSLMQKGQQM-----LARCPKSAETN----IDQDINN 4525
+ AA E +E T K ++Q+ Q L R E + ++ ++
Sbjct: 1423 LQQRLAALEQEEAEAREKVTHTQKVVLQQDPQQAREHALLRLQLEEEQHRRQLLEGELET 1482
Query: 4526 LKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTV 4585
L+ K ++E K +++E + L+ D + + + +L SR LD
Sbjct: 1483 LRRKLAALE------KAEVKEKVVLSESVQVEKGDTEQEIQRLKSSLEEESRSKRELDVE 1536
Query: 4586 LFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQR 4645
+ +++ NS + ++ + H K ++Q++ L L S + +
Sbjct: 1537 VSRLEARLSELEFHNSKSSKELDFLREENH-KLQLERQNLQLETRRLQSEINMAATETRD 1595
Query: 4646 LVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQ--HKE 4703
L R++ A WS E + S D +LEI D+++ +L K
Sbjct: 1596 L----RNMTVADSGTNHDSRLWSLERELDDLKRLSKDKDLEI----DELQKRLGSVAVKR 1647
Query: 4704 FQKSLGAKHSVYDTTNRTGRSL 4725
Q+ + S+ TGR L
Sbjct: 1648 EQRENHLRRSIVVIHPDTGREL 1669
Score = 61.6 bits (148), Expect = 2e-08
Identities = 196/1134 (17%), Positives = 447/1134 (39%), Gaps = 143/1134 (12%)
Query: 1857 HYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELEN---LEAGADDINGL 1913
H L +++K+ + + L++ L++ E+ L Q + E+ L++ ++ +
Sbjct: 599 HLLQLLDLAQEKVDVANRLEKSLQQSWELLATHENHLNQDDTVPESSRVLDSKGQELAAM 658
Query: 1914 MTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLD 1973
+L+ QKS +V + L+AAK CS + E Q
Sbjct: 659 ACELQAQKSLLGEVEQN--------------LQAAKQCSSTLASRFQEHCPDLERQEAEV 704
Query: 1974 HAT-DRFRSLYSKCNVLGNNLKDLVDKYQHYE---DASCGLLAGLQACEATASKHLSEPI 2029
H RF +L + +L+ Y+H+ D L + + E + LS+
Sbjct: 705 HKLGQRFNNLRQQVERRAQSLQSAKAAYEHFHRGHDHVLQFLVSIPSYEPQETDSLSQ-- 762
Query: 2030 AVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIV 2089
++ +L+ K L +I+S++ V+K+ ++ A ++ LD
Sbjct: 763 ------METKLKNQKNLLDEIASREQEVQKICANSQQYQQAVKDYELEAEKLRSLLDLEN 816
Query: 2090 GRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQD 2149
GR +SK +LQ T+ + L + K +N LQ
Sbjct: 817 GRSSHVSKRA-----RLQSPATKVKEEEAAL------------AAKFTEVYAINRQRLQ- 858
Query: 2150 IISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHK 2209
N+ ++ +Q + +E +++ + A ++ ++ + + R + ++ K
Sbjct: 859 ----NLEFALNLLRQQPEVEVTHETLQRNRPDSGVEEAWKIRKELDEETERRRQLENEVK 914
Query: 2210 ETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLE 2269
T ++ L+ Q E+ + VP + E Q +Q + +E +
Sbjct: 915 STQEEIWTLRN------------QGPQESVVRKEVLKKVPDPVLEESFQQLQRTLAEE-Q 961
Query: 2270 HK-----KHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSC 2324
HK + LE L L+ + + V+++ + + D + + +E + +
Sbjct: 962 HKNQLLQEELEALQLQLRALEQETRDGGQEYVVKEVLRIEPD-RAQADEVLQLREELEAL 1020
Query: 2325 QEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQK 2384
+ Q A + V L+ + ++ Q +++ K L++ +L+ ++ + Q+
Sbjct: 1021 RRQKGAREAEVLLLQQRVAALAEEKSRAQEKVTEKEVVK-LQNDPQLEAEYQQLQEDHQR 1079
Query: 2385 VNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDI 2444
+ +S + K + ++ EG T E K + +++++D+
Sbjct: 1080 QDQLREKQEEELSFLQDKLKRLEKERA-----MAEGKITVKEVLKVEKDAAT-EREVSDL 1133
Query: 2445 SHGYEDLGLLLKDKIAELNTKLSKLQKAQEESS--AMMQWLQKMNKTATKWQQTPAPTDT 2502
+ YED + E L K+ +EE++ + + ++++ + K + A
Sbjct: 1134 TRQYEDEAAKARASQREKTELLRKIWALEEENAKVVVQEKVREIVRPDPKAESEVANLRL 1193
Query: 2503 EAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQE 2562
E V+ Q + + E +L+ ++++ L+ + + +E T E ++K E++ + Q
Sbjct: 1194 ELVE-QERKYRGAEEQLRSYQSELEALRRRGPQ-VEVKEVTKEVIKYKTD-PEMEKELQR 1250
Query: 2563 LNQLTIDRQQKLEESSNNLTQFQTVEAQLKQW--LVEKELMVSVLGPLSIDPNMLNTQRQ 2620
L + +D+ + +E + Q + LK V+ + +V + DP +
Sbjct: 1251 LREEIVDKTRLIERCDLEIYQLKKEIQALKDTKPQVQTKEVVQEILQFQEDP-QTKEEVA 1309
Query: 2621 QVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPS-LRGIVKEQLAAVTQKWDSLTGQLS 2679
++ L E ++ E+ A+ + ++R E+ S ++ V +Q ++ L + S
Sbjct: 1310 SLRAKLSEEQKKQVDLERERASQEEQIARKEEELSRVKERVVQQEVVRYEEEPGLRAEAS 1369
Query: 2680 DRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQE 2739
+ ID + + + ++ LR L + ++L+ +L ++LE ++ ++E
Sbjct: 1370 AFAESIDVELRQIDKLRAELRRLQRRRTELERQL--------------EELERERQARRE 1415
Query: 2740 IQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSAC 2799
++E Q L + L+AL +E E +A V H Q
Sbjct: 1416 AERE------VQRLQQRLAALEQE---------------------EAEAREKVTHTQKVV 1448
Query: 2800 ASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLE---SLIKDHKDFSKTLTAQSHM 2856
Q Q +R+ +EEQ++ + +L+ L + ++ + K + ++S
Sbjct: 1449 L--QQDPQQAREHALLRLQLEEEQHRRQLLEGELETLRRKLAALEKAEVKEKVVLSESVQ 1506
Query: 2857 YEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLE--KALKY 2914
EK E E LK+ E++ + +L+ + + +++ +K + L+ + +
Sbjct: 1507 VEKGDTEQEIQRLKSSLEEESRSKRELDVEVSRLEARLSELEFHNSKSSKELDFLREENH 1566
Query: 2915 KEQVE---------TLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMD 2959
K Q+E L I+ +++ G N ++L SL++E+D
Sbjct: 1567 KLQLERQNLQLETRRLQSEINMAATETRDLRNMTVADSGTNHDSRLWSLERELD 1620
Score = 53.1 bits (126), Expect = 7e-06
Identities = 146/848 (17%), Positives = 343/848 (40%), Gaps = 107/848 (12%)
Query: 991 LANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEH----- 1045
L N ++ + + TL ++ +SVV L D + + ++ L E
Sbjct: 909 LENEVKSTQEEIWTLRNQGP--QESVVRKEVLKKVPDPVLEESFQQLQRTLAEEQHKNQL 966
Query: 1046 -QQVLSNLQSRFEDFLEDSQES-QVFSGSDITQLEKE---VNVCKQYYQELLKSAEREEQ 1100
Q+ L LQ + +++++ Q + ++ ++E + + Q +EL ++
Sbjct: 967 LQEELEALQLQLRALEQETRDGGQEYVVKEVLRIEPDRAQADEVLQLREELEALRRQKGA 1026
Query: 1101 EESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKEL--ER 1158
E+ L V + ++++ + L+ D E+ ++ +++ +++ E+
Sbjct: 1027 REAEVLLLQQRVAALAEEKSRAQEKVTEKEVVKLQNDPQLEAEYQQLQEDHQRQDQLREK 1086
Query: 1159 LKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQ--NMNQVYSMSSTYIDKLKTVNL 1216
+++L + +K + + A + T++ L V +V ++ Y D+
Sbjct: 1087 QEEELSFLQDKLKRLEKERAMAEGKITVKEVLKVEKDAATEREVSDLTRQYEDEAAKARA 1146
Query: 1217 VLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLI-------STLKQWRSEVDEKRQVF 1269
+ E L K++ + EE A + + + ++ S + R E+ E+ + +
Sbjct: 1147 --SQREKTELLRKIWALE--EENAKVVVQEKVREIVRPDPKAESEVANLRLELVEQERKY 1202
Query: 1270 HALEDELQKAKAISDEMFKTYKE---RDLDFDWHKEKADQLVER-WQNVHVQIDNRLRDL 1325
E++L+ ++ + + + + +++ + K K D +E+ Q + +I ++ R +
Sbjct: 1203 RGAEEQLRSYQSELEALRRRGPQVEVKEVTKEVIKYKTDPEMEKELQRLREEIVDKTRLI 1262
Query: 1326 EGIGKSLKYYRDTYHPLDDWIQQVET---TQRKIQENQPENSK----TLATQLNQQKMLV 1378
E + + L D QV+T Q +Q + +K +L +L++++
Sbjct: 1263 ERCDLEIYQLKKEIQALKDTKPQVQTKEVVQEILQFQEDPQTKEEVASLRAKLSEEQKKQ 1322
Query: 1379 SEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQ 1438
++E +++ +E E+ + VK+ +Q R + + + S D+ ++
Sbjct: 1323 VDLERERASQEEQIARKEEELSRVKERVVQQEVVR--YEEEPGLRAEASAFAESIDVELR 1380
Query: 1439 EFMDLRTRYTALVTLMT-------------QYIKFAGDSLKRLEEEEKSLEEEKKEHVEK 1485
+ LR L T Q + A ++RL++ +LE+E+ E EK
Sbjct: 1381 QIDKLRAELRRLQRRRTELERQLEELERERQARREAEREVQRLQQRLAALEQEEAEAREK 1440
Query: 1486 AKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDK 1545
QK V +D ++A + + ++ EE +++ L L+T++ K
Sbjct: 1441 VTHTQKVVLQ-----QDPQQARE--HALLRLQLEEEQHRRQLLEGELETLR-------RK 1486
Query: 1546 MTDEERNELEKQVKTLQESYNLLFSESLKQLQ--------ESQTSGDVKVEEKIVAERQQ 1597
+ E+ E++++V L ES + ++ +++Q ES++ ++ VE + R
Sbjct: 1487 LAALEKAEVKEKV-VLSESVQVEKGDTEQEIQRLKSSLEEESRSKRELDVEVSRLEARLS 1545
Query: 1598 E---YKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQAL 1654
E + K D L + ++L +E + Q + LQ ++ +A
Sbjct: 1546 ELEFHNSKSSKELDFLREENHKL------------QLERQNLQLETRRLQSEINMAATET 1593
Query: 1655 AEVVKNTENFLKENGEKLSQEDKAL--IEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTA 1712
++ T + ++G + D L +E++L++ K + +L+ ++ +K L V
Sbjct: 1594 RDLRNMT---VADSG---TNHDSRLWSLERELDDLKRLSKDKDLEIDELQKRLGSVAVKR 1647
Query: 1713 IKEETEKVAAV--------KQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTH 1764
+ E ++ ++L + L+DW V S+ + V NG
Sbjct: 1648 EQRENHLRRSIVVIHPDTGRELSPEEAHRAGLIDWNMFVKLRSQECDWEEISVKGPNGES 1707
Query: 1765 FQEGDGKS 1772
D KS
Sbjct: 1708 SVIHDRKS 1715
Score = 35.4 bits (80), Expect = 1.6
Identities = 67/320 (20%), Positives = 133/320 (41%), Gaps = 57/320 (17%)
Query: 4669 KLMEWLEESEKSLDS-ELEIANDPDKIKTQLAQHKE----------FQKSLGAKHSVY-- 4715
+L E +E+ +K+ D E I + K+++ LA+ +E QK L ++ +Y
Sbjct: 26 ELSELIEQLQKNADQVEKNIVDTEAKMQSDLARLQEGRQPEHRDVTLQKVLDSEKLLYVL 85
Query: 4716 --DTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQF 4773
D + +A+D +L + ++ LR K I +V+
Sbjct: 86 EADAAIAKHMKHPQGDMIAEDIRQLKERVTNLRGKHKQIYRLAVKE-------------- 131
Query: 4774 TDALQALIDWLYRVEPQLAE--DQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRS 4831
+ ++W VE +L + +Q D+ LV + ++ H F E V+A+
Sbjct: 132 ---VDPQVNWAALVEEKLDKLNNQSFGTDLPLVDHQVEEHNIFHNE-------VKAIGPH 181
Query: 4832 ARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEW 4891
+ +G ++ +S EL +++ + A S ++Q L + +++ L W
Sbjct: 182 LAK--DGDKEQNS-------ELRAKYQKLLAASQARQQHLSSL----QDYMQRCTNELYW 228
Query: 4892 LAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKK-LEEKRAELNKATTMGDTVLAICHPD 4950
L + + R D + Q++ F+ + LE K +NK + GD +LA HP
Sbjct: 229 LDQQAKG-RMQYDWSDRNLDYPSRRRQYENFINRNLEAKEERINKLHSEGDQLLAAEHPG 287
Query: 4951 SITTIKHWITIIRARFEEVL 4970
+I+ + + A ++E L
Sbjct: 288 R-NSIEAHMEAVHADWKEYL 306
Score = 33.1 bits (74), Expect = 7.9
Identities = 70/347 (20%), Positives = 138/347 (39%), Gaps = 43/347 (12%)
Query: 4315 LEERIINRQHKLEGAL-LALGQFQHALDELLAWLTHTEGLLSE--QKPVGGDPKAIEIEL 4371
L+ER+ N + K + LA+ + +D + W E L + + G D ++ ++
Sbjct: 110 LKERVTNLRGKHKQIYRLAVKE----VDPQVNWAALVEEKLDKLNNQSFGTDLPLVDHQV 165
Query: 4372 AKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQR 4431
+H++ N+V A G L + E+ S L+ K +Q +L ++ R
Sbjct: 166 EEHNIFHNEVKA----------IGPHLAKDGDKEQNSELRAK-------YQKLLAASQAR 208
Query: 4432 KQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFE 4491
+Q L + E+ L Q ++ + + L P ++ N + E
Sbjct: 209 QQHLSSLQDYMQRCTNELYWLDQQAKGRMQYDWSDRNLD-YPSRRRQYENF---INRNLE 264
Query: 4492 AKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKL--NERKTKLEEALN 4549
AKEE L +G Q+LA +I+ + + W+ L E K E +
Sbjct: 265 AKEERINKLHSEGDQLLA-AEHPGRNSIEAHMEAVHADWKEYLNLLICEESHLKYMEDYH 323
Query: 4550 LAMEFHNSLQDFINWLTQAEQTLNVASRPSL----ILDTVLFQIDEHKVFANEVNSHREQ 4605
+FH ++D L + + LN P ++ +L ++D+ + ++ + +
Sbjct: 324 ---QFHEDVKDAQELLRKVDSDLNQKYGPDFKDRYQIELLLRELDDQE---KVLDKYEDV 377
Query: 4606 IIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRS 4652
+ L K G + +++ L K + + +E Q L+ RG S
Sbjct: 378 VQGLQKRGQQVVPLKYRRETPL-KPIPVEALCDFEG-EQGLISRGYS 422
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.312 0.128 0.354
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 191,482,153
Number of Sequences: 37866
Number of extensions: 8460573
Number of successful extensions: 64046
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 208
Number of HSP's successfully gapped in prelim test: 1270
Number of HSP's that attempted gapping in prelim test: 33226
Number of HSP's gapped (non-prelim): 15758
length of query: 5537
length of database: 18,247,518
effective HSP length: 125
effective length of query: 5412
effective length of database: 13,514,268
effective search space: 73139218416
effective search space used: 73139218416
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 74 (33.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.