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Search of human proteins with 221307566
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|221307566 DENN/MADD domain containing 4A isoform 2 [Homo
sapiens]
(1863 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|221307566 DENN/MADD domain containing 4A isoform 2 [Homo sapi... 3770 0.0
gi|221307568 DENN/MADD domain containing 4A isoform 1 [Homo sapi... 3749 0.0
gi|94818781 DENN/MADD domain containing 4C [Homo sapiens] 1316 0.0
gi|148922920 DENN/MADD domain containing 4B [Homo sapiens] 1041 0.0
gi|29788755 SET binding factor 2 [Homo sapiens] 137 1e-31
gi|122891862 DENN/MADD domain containing 5B [Homo sapiens] 133 1e-30
gi|44889475 RAB6 interacting protein 1 [Homo sapiens] 127 1e-28
gi|239735519 SET binding factor 1 [Homo sapiens] 125 5e-28
gi|21361991 DENN/MADD domain containing 2D [Homo sapiens] 91 1e-17
gi|209863002 MAP-kinase activating death domain-containing prote... 90 2e-17
gi|209862998 MAP-kinase activating death domain-containing prote... 90 2e-17
gi|209862994 MAP-kinase activating death domain-containing prote... 90 2e-17
gi|18860873 MAP-kinase activating death domain-containing protei... 90 2e-17
gi|209862987 MAP-kinase activating death domain-containing prote... 90 2e-17
gi|209862983 MAP-kinase activating death domain-containing prote... 90 2e-17
gi|209862979 MAP-kinase activating death domain-containing prote... 90 2e-17
gi|209862975 MAP-kinase activating death domain-containing prote... 90 2e-17
gi|209862971 MAP-kinase activating death domain-containing prote... 90 2e-17
gi|209571517 MAP-kinase activating death domain-containing prote... 90 2e-17
gi|154813195 DENN/MADD domain containing 2A [Homo sapiens] 86 4e-16
gi|218563726 DENN/MADD domain containing 1B isoform 1 [Homo sapi... 83 2e-15
gi|47132529 suppression of tumorigenicity 5 isoform 1 [Homo sapi... 80 2e-14
gi|47132532 suppression of tumorigenicity 5 isoform 1 [Homo sapi... 80 2e-14
gi|21264614 suppression of tumorigenicity 5 isoform 2 [Homo sapi... 80 2e-14
gi|121949817 DENN/MADD domain containing 2C [Homo sapiens] 79 3e-14
gi|55749789 DENN/MADD domain containing 1A isoform 2 [Homo sapiens] 78 7e-14
gi|55749779 DENN/MADD domain containing 1A isoform 1 [Homo sapiens] 78 7e-14
gi|50345870 DENN/MADD domain containing 3 [Homo sapiens] 76 3e-13
gi|188219541 DENN/MADD domain containing 1B isoform 2 [Homo sapi... 75 5e-13
gi|113205087 DENN/MADD domain containing 1C [Homo sapiens] 64 2e-09
>gi|221307566 DENN/MADD domain containing 4A isoform 2 [Homo sapiens]
Length = 1863
Score = 3770 bits (9777), Expect = 0.0
Identities = 1863/1863 (100%), Positives = 1863/1863 (100%)
Query: 1 MIEDKGPRVADYFVVAGLTDVSKPLEEEIHFNDACHKVAKPKEPITDVSVIIKSLGEEVP 60
MIEDKGPRVADYFVVAGLTDVSKPLEEEIHFNDACHKVAKPKEPITDVSVIIKSLGEEVP
Sbjct: 1 MIEDKGPRVADYFVVAGLTDVSKPLEEEIHFNDACHKVAKPKEPITDVSVIIKSLGEEVP 60
Query: 61 QDYICIDVTPTGLSADLNNGSLVGPQIYLCYRRGRDKPPLTDLGVLYDWKERLKQGCEII 120
QDYICIDVTPTGLSADLNNGSLVGPQIYLCYRRGRDKPPLTDLGVLYDWKERLKQGCEII
Sbjct: 61 QDYICIDVTPTGLSADLNNGSLVGPQIYLCYRRGRDKPPLTDLGVLYDWKERLKQGCEII 120
Query: 121 QSTPYGRPANISGSTSSQRIYITYRRASENMTQNTLAVTDICIIIPSKGESPPHTFCKVD 180
QSTPYGRPANISGSTSSQRIYITYRRASENMTQNTLAVTDICIIIPSKGESPPHTFCKVD
Sbjct: 121 QSTPYGRPANISGSTSSQRIYITYRRASENMTQNTLAVTDICIIIPSKGESPPHTFCKVD 180
Query: 181 KNLNNSMWGSAVYLCYKKSVAKTNTVSYKAGLICRYPQEDYESFSLPESVPLFCLPMGAT 240
KNLNNSMWGSAVYLCYKKSVAKTNTVSYKAGLICRYPQEDYESFSLPESVPLFCLPMGAT
Sbjct: 181 KNLNNSMWGSAVYLCYKKSVAKTNTVSYKAGLICRYPQEDYESFSLPESVPLFCLPMGAT 240
Query: 241 IECWPSNSKYPLPVFSTFVLTGASAEKVYGAAIQFYEPYSEENLTEKQRLLLGLTSADGK 300
IECWPSNSKYPLPVFSTFVLTGASAEKVYGAAIQFYEPYSEENLTEKQRLLLGLTSADGK
Sbjct: 241 IECWPSNSKYPLPVFSTFVLTGASAEKVYGAAIQFYEPYSEENLTEKQRLLLGLTSADGK 300
Query: 301 SDSSKTIHTNKCICLLSHWPFFDAFRKFLTFLYRYSISGPHVLPIEKHISHFMHKVPFPS 360
SDSSKTIHTNKCICLLSHWPFFDAFRKFLTFLYRYSISGPHVLPIEKHISHFMHKVPFPS
Sbjct: 301 SDSSKTIHTNKCICLLSHWPFFDAFRKFLTFLYRYSISGPHVLPIEKHISHFMHKVPFPS 360
Query: 361 PQRPRILVQLSPHDNLILSQPVSSPLPLSGGKFSTLLQNLGPENAVTLLVFAVTEHKILI 420
PQRPRILVQLSPHDNLILSQPVSSPLPLSGGKFSTLLQNLGPENAVTLLVFAVTEHKILI
Sbjct: 361 PQRPRILVQLSPHDNLILSQPVSSPLPLSGGKFSTLLQNLGPENAVTLLVFAVTEHKILI 420
Query: 421 HSLRPSVLTSVTEALVSMIFPFHWPCPYVPLCPLALADVLSAPCPFIVGIDSRYFDLYDP 480
HSLRPSVLTSVTEALVSMIFPFHWPCPYVPLCPLALADVLSAPCPFIVGIDSRYFDLYDP
Sbjct: 421 HSLRPSVLTSVTEALVSMIFPFHWPCPYVPLCPLALADVLSAPCPFIVGIDSRYFDLYDP 480
Query: 481 PPDVSCVDVDTNTISQIGDKKNVAWKILPKKPCKNLMNTLNNLHQQLAKLQQRPRDDGLM 540
PPDVSCVDVDTNTISQIGDKKNVAWKILPKKPCKNLMNTLNNLHQQLAKLQQRPRDDGLM
Sbjct: 481 PPDVSCVDVDTNTISQIGDKKNVAWKILPKKPCKNLMNTLNNLHQQLAKLQQRPRDDGLM 540
Query: 541 DLAINDYDFNSGKRLHMIDLEIQEAFLFFMASILKGYRSYLRPITQAPSETATDAASLFA 600
DLAINDYDFNSGKRLHMIDLEIQEAFLFFMASILKGYRSYLRPITQAPSETATDAASLFA
Sbjct: 541 DLAINDYDFNSGKRLHMIDLEIQEAFLFFMASILKGYRSYLRPITQAPSETATDAASLFA 600
Query: 601 LQAFLRSRDRSHQKFYNMMTKTQMFIRFIEECSFVSDKDASLAFFDDCVDKVDMDKSGEV 660
LQAFLRSRDRSHQKFYNMMTKTQMFIRFIEECSFVSDKDASLAFFDDCVDKVDMDKSGEV
Sbjct: 601 LQAFLRSRDRSHQKFYNMMTKTQMFIRFIEECSFVSDKDASLAFFDDCVDKVDMDKSGEV 660
Query: 661 RLIELDESFKSEHTVFVTPPEIPHLPNGEEPPLQYSYNGFPVLRNNLFERPEGFLQAKKN 720
RLIELDESFKSEHTVFVTPPEIPHLPNGEEPPLQYSYNGFPVLRNNLFERPEGFLQAKKN
Sbjct: 661 RLIELDESFKSEHTVFVTPPEIPHLPNGEEPPLQYSYNGFPVLRNNLFERPEGFLQAKKN 720
Query: 721 KLPSKSSSPNSPLPMFRRTKQEIKSAHKIAKRYSSIPQMWSRCLLRHCYGLWFICLPAYV 780
KLPSKSSSPNSPLPMFRRTKQEIKSAHKIAKRYSSIPQMWSRCLLRHCYGLWFICLPAYV
Sbjct: 721 KLPSKSSSPNSPLPMFRRTKQEIKSAHKIAKRYSSIPQMWSRCLLRHCYGLWFICLPAYV 780
Query: 781 KVCHSKVRALKTAYDVLKKMQSKKMDPPDEVCYRILMQLCGQYDQPVLAVRVLFEMQKAG 840
KVCHSKVRALKTAYDVLKKMQSKKMDPPDEVCYRILMQLCGQYDQPVLAVRVLFEMQKAG
Sbjct: 781 KVCHSKVRALKTAYDVLKKMQSKKMDPPDEVCYRILMQLCGQYDQPVLAVRVLFEMQKAG 840
Query: 841 IDPNAITYGYYNKAVLESTWPSRSRSGYFLWTKVRNVVLGVTQFKRALKKHAHLSQTTLS 900
IDPNAITYGYYNKAVLESTWPSRSRSGYFLWTKVRNVVLGVTQFKRALKKHAHLSQTTLS
Sbjct: 841 IDPNAITYGYYNKAVLESTWPSRSRSGYFLWTKVRNVVLGVTQFKRALKKHAHLSQTTLS 900
Query: 901 GGQSDLGYNSLSKDEVRRGDTSTEDIQEEKDKKGSDCSSLSESESTKGSADCLPKLSYQN 960
GGQSDLGYNSLSKDEVRRGDTSTEDIQEEKDKKGSDCSSLSESESTKGSADCLPKLSYQN
Sbjct: 901 GGQSDLGYNSLSKDEVRRGDTSTEDIQEEKDKKGSDCSSLSESESTKGSADCLPKLSYQN 960
Query: 961 SSSIVRLTGTSNNSAGKISGESMESTPELLLISSLEDTNETRNIQSRCFRKRHKSDNETN 1020
SSSIVRLTGTSNNSAGKISGESMESTPELLLISSLEDTNETRNIQSRCFRKRHKSDNETN
Sbjct: 961 SSSIVRLTGTSNNSAGKISGESMESTPELLLISSLEDTNETRNIQSRCFRKRHKSDNETN 1020
Query: 1021 LQQQVVWGNRNRNLSGGVLMGFMLNRINQEATPGDIVEKLGADAKILSNVISKSTRPNTL 1080
LQQQVVWGNRNRNLSGGVLMGFMLNRINQEATPGDIVEKLGADAKILSNVISKSTRPNTL
Sbjct: 1021 LQQQVVWGNRNRNLSGGVLMGFMLNRINQEATPGDIVEKLGADAKILSNVISKSTRPNTL 1080
Query: 1081 DIGKPPLRSKRDSLEKESSDDDTPFDGSNYLADKVDSPVIFDLEDLDSETDVSKAGCVAT 1140
DIGKPPLRSKRDSLEKESSDDDTPFDGSNYLADKVDSPVIFDLEDLDSETDVSKAGCVAT
Sbjct: 1081 DIGKPPLRSKRDSLEKESSDDDTPFDGSNYLADKVDSPVIFDLEDLDSETDVSKAGCVAT 1140
Query: 1141 QNPKRIQRMNSSFSVKPFEKTDVATGFDPLSLLVAETEQQQKEEEEEDEDDSKSISTPSA 1200
QNPKRIQRMNSSFSVKPFEKTDVATGFDPLSLLVAETEQQQKEEEEEDEDDSKSISTPSA
Sbjct: 1141 QNPKRIQRMNSSFSVKPFEKTDVATGFDPLSLLVAETEQQQKEEEEEDEDDSKSISTPSA 1200
Query: 1201 RRDLAEEIVMYMNNMSSPLTSRTPSIDLQRACDDKLNKKSPPLVKACRRSSLPPNSPKPV 1260
RRDLAEEIVMYMNNMSSPLTSRTPSIDLQRACDDKLNKKSPPLVKACRRSSLPPNSPKPV
Sbjct: 1201 RRDLAEEIVMYMNNMSSPLTSRTPSIDLQRACDDKLNKKSPPLVKACRRSSLPPNSPKPV 1260
Query: 1261 RLTKSKSYTKSEEKPRDRLWSSPAFSPTCPFREESQDTLTHSSPSFNLDTLLVPKLDVLR 1320
RLTKSKSYTKSEEKPRDRLWSSPAFSPTCPFREESQDTLTHSSPSFNLDTLLVPKLDVLR
Sbjct: 1261 RLTKSKSYTKSEEKPRDRLWSSPAFSPTCPFREESQDTLTHSSPSFNLDTLLVPKLDVLR 1320
Query: 1321 NSMFTAGKGVAEKASKWYSRFTMYTTSSKDQSSDRTSLSSVGAQDSESTSLTDEDVCHEL 1380
NSMFTAGKGVAEKASKWYSRFTMYTTSSKDQSSDRTSLSSVGAQDSESTSLTDEDVCHEL
Sbjct: 1321 NSMFTAGKGVAEKASKWYSRFTMYTTSSKDQSSDRTSLSSVGAQDSESTSLTDEDVCHEL 1380
Query: 1381 EGPISSQETSATSGTKRIDLSRISLESSASLEGSLSKFALPGKSEVTSSFNASNTNIFQN 1440
EGPISSQETSATSGTKRIDLSRISLESSASLEGSLSKFALPGKSEVTSSFNASNTNIFQN
Sbjct: 1381 EGPISSQETSATSGTKRIDLSRISLESSASLEGSLSKFALPGKSEVTSSFNASNTNIFQN 1440
Query: 1441 YAMEVLISSCSRCRTCDCLVHDEEIMAGWTADDSNLNTTCPFCGNIFLPFLNIEIRDLRR 1500
YAMEVLISSCSRCRTCDCLVHDEEIMAGWTADDSNLNTTCPFCGNIFLPFLNIEIRDLRR
Sbjct: 1441 YAMEVLISSCSRCRTCDCLVHDEEIMAGWTADDSNLNTTCPFCGNIFLPFLNIEIRDLRR 1500
Query: 1501 PGRYFLKSSPSTENMHFPSSISSQTRQSCISTSASGLDTSALSVQGNFDLNSKSKLQENF 1560
PGRYFLKSSPSTENMHFPSSISSQTRQSCISTSASGLDTSALSVQGNFDLNSKSKLQENF
Sbjct: 1501 PGRYFLKSSPSTENMHFPSSISSQTRQSCISTSASGLDTSALSVQGNFDLNSKSKLQENF 1560
Query: 1561 CTRSIQIPANRSKTAMSKCPIFPMARSISTSGPLDKEDTGRQKLISTGSLPATLQGATDS 1620
CTRSIQIPANRSKTAMSKCPIFPMARSISTSGPLDKEDTGRQKLISTGSLPATLQGATDS
Sbjct: 1561 CTRSIQIPANRSKTAMSKCPIFPMARSISTSGPLDKEDTGRQKLISTGSLPATLQGATDS 1620
Query: 1621 LGLEWHLPSPDPVTVPYLSPLVVWKELESLLENEGDHAITVADFVDHHPIVFWNLVWYFR 1680
LGLEWHLPSPDPVTVPYLSPLVVWKELESLLENEGDHAITVADFVDHHPIVFWNLVWYFR
Sbjct: 1621 LGLEWHLPSPDPVTVPYLSPLVVWKELESLLENEGDHAITVADFVDHHPIVFWNLVWYFR 1680
Query: 1681 RLDLPSNLPGLILSSEHCNKYSKIPRHCMSEDSKYVLIQMLWDNMKLHQDPGQPLYILWN 1740
RLDLPSNLPGLILSSEHCNKYSKIPRHCMSEDSKYVLIQMLWDNMKLHQDPGQPLYILWN
Sbjct: 1681 RLDLPSNLPGLILSSEHCNKYSKIPRHCMSEDSKYVLIQMLWDNMKLHQDPGQPLYILWN 1740
Query: 1741 AHTQKYPMVHLLQKSDNSFNQELLKSMVKSIKMNDVYGPMSQILETLNKCPHFKRQRSLY 1800
AHTQKYPMVHLLQKSDNSFNQELLKSMVKSIKMNDVYGPMSQILETLNKCPHFKRQRSLY
Sbjct: 1741 AHTQKYPMVHLLQKSDNSFNQELLKSMVKSIKMNDVYGPMSQILETLNKCPHFKRQRSLY 1800
Query: 1801 REILFLSLVALGRENIDIDAFDKEYKMAYDRLTPSQVKSTHNCDRPPSTGVMECRKTFGE 1860
REILFLSLVALGRENIDIDAFDKEYKMAYDRLTPSQVKSTHNCDRPPSTGVMECRKTFGE
Sbjct: 1801 REILFLSLVALGRENIDIDAFDKEYKMAYDRLTPSQVKSTHNCDRPPSTGVMECRKTFGE 1860
Query: 1861 PYL 1863
PYL
Sbjct: 1861 PYL 1863
>gi|221307568 DENN/MADD domain containing 4A isoform 1 [Homo sapiens]
Length = 1906
Score = 3749 bits (9723), Expect = 0.0
Identities = 1863/1906 (97%), Positives = 1863/1906 (97%), Gaps = 43/1906 (2%)
Query: 1 MIEDKGPRVADYFVVAGLTDVSKPLEEEIHFNDACHKVAKPKEPITDVSVIIKSLGEEVP 60
MIEDKGPRVADYFVVAGLTDVSKPLEEEIHFNDACHKVAKPKEPITDVSVIIKSLGEEVP
Sbjct: 1 MIEDKGPRVADYFVVAGLTDVSKPLEEEIHFNDACHKVAKPKEPITDVSVIIKSLGEEVP 60
Query: 61 QDYICIDVTPTGLSADLNNGSLVGPQIYLCYRRGRDKPPLTDLGVLYDWKERLKQGCEII 120
QDYICIDVTPTGLSADLNNGSLVGPQIYLCYRRGRDKPPLTDLGVLYDWKERLKQGCEII
Sbjct: 61 QDYICIDVTPTGLSADLNNGSLVGPQIYLCYRRGRDKPPLTDLGVLYDWKERLKQGCEII 120
Query: 121 QSTPYGRPANISGSTSSQRIYITYRRASENMTQNTLAVTDICIIIPSKGESPPHTFCKVD 180
QSTPYGRPANISGSTSSQRIYITYRRASENMTQNTLAVTDICIIIPSKGESPPHTFCKVD
Sbjct: 121 QSTPYGRPANISGSTSSQRIYITYRRASENMTQNTLAVTDICIIIPSKGESPPHTFCKVD 180
Query: 181 KNLNNSMWGSAVYLCYKKSVAKTNTVSYKAGLICRYPQEDYESFSLPESVPLFCLPMGAT 240
KNLNNSMWGSAVYLCYKKSVAKTNTVSYKAGLICRYPQEDYESFSLPESVPLFCLPMGAT
Sbjct: 181 KNLNNSMWGSAVYLCYKKSVAKTNTVSYKAGLICRYPQEDYESFSLPESVPLFCLPMGAT 240
Query: 241 IECWPSNSKYPLPVFSTFVLTGASAEKVYGAAIQFYEPYSEENLTEKQRLLLGLTSADGK 300
IECWPSNSKYPLPVFSTFVLTGASAEKVYGAAIQFYEPYSEENLTEKQRLLLGLTSADGK
Sbjct: 241 IECWPSNSKYPLPVFSTFVLTGASAEKVYGAAIQFYEPYSEENLTEKQRLLLGLTSADGK 300
Query: 301 SDSSKTIHTNKCICLLSHWPFFDAFRKFLTFLYRYSISGPHVLPIEKHISHFMHKVPFPS 360
SDSSKTIHTNKCICLLSHWPFFDAFRKFLTFLYRYSISGPHVLPIEKHISHFMHKVPFPS
Sbjct: 301 SDSSKTIHTNKCICLLSHWPFFDAFRKFLTFLYRYSISGPHVLPIEKHISHFMHKVPFPS 360
Query: 361 PQRPRILVQLSPHDNLILSQPVSSPLPLSGGKFSTLLQNLGPENAVTLLVFAVTEHKILI 420
PQRPRILVQLSPHDNLILSQPVSSPLPLSGGKFSTLLQNLGPENAVTLLVFAVTEHKILI
Sbjct: 361 PQRPRILVQLSPHDNLILSQPVSSPLPLSGGKFSTLLQNLGPENAVTLLVFAVTEHKILI 420
Query: 421 HSLRPSVLTSVTEALVSMIFPFHWPCPYVPLCPLALADVLSAPCPFIVGIDSRYFDLYDP 480
HSLRPSVLTSVTEALVSMIFPFHWPCPYVPLCPLALADVLSAPCPFIVGIDSRYFDLYDP
Sbjct: 421 HSLRPSVLTSVTEALVSMIFPFHWPCPYVPLCPLALADVLSAPCPFIVGIDSRYFDLYDP 480
Query: 481 PPDVSCVDVDTNTISQIGDKKNVAWKILPKKPCKNLMNTLNNLHQQLAKLQQRPRDDGLM 540
PPDVSCVDVDTNTISQIGDKKNVAWKILPKKPCKNLMNTLNNLHQQLAKLQQRPRDDGLM
Sbjct: 481 PPDVSCVDVDTNTISQIGDKKNVAWKILPKKPCKNLMNTLNNLHQQLAKLQQRPRDDGLM 540
Query: 541 DLAINDYDFNSGKRLHMIDLEIQEAFLFFMASILKGYRSYLRPITQAPSETATDAASLFA 600
DLAINDYDFNSGKRLHMIDLEIQEAFLFFMASILKGYRSYLRPITQAPSETATDAASLFA
Sbjct: 541 DLAINDYDFNSGKRLHMIDLEIQEAFLFFMASILKGYRSYLRPITQAPSETATDAASLFA 600
Query: 601 LQAFLRSRDRSHQKFYNMMTKTQMFIRFIEECSFVSDKDASLAFFDDCVDKVDMDKSGEV 660
LQAFLRSRDRSHQKFYNMMTKTQMFIRFIEECSFVSDKDASLAFFDDCVDKVDMDKSGEV
Sbjct: 601 LQAFLRSRDRSHQKFYNMMTKTQMFIRFIEECSFVSDKDASLAFFDDCVDKVDMDKSGEV 660
Query: 661 RLIELDESFKSEHTVFVTPPEIPHLPNGEEPPLQYSYNGFPVLRNNLFERPEGFLQAKKN 720
RLIELDESFKSEHTVFVTPPEIPHLPNGEEPPLQYSYNGFPVLRNNLFERPEGFLQAKKN
Sbjct: 661 RLIELDESFKSEHTVFVTPPEIPHLPNGEEPPLQYSYNGFPVLRNNLFERPEGFLQAKKN 720
Query: 721 KLPSKSSSPNSPLPMFRRTKQEIKSAHKIAKRYSSIPQMWSRCLLRHCYGLWFICLPAYV 780
KLPSKSSSPNSPLPMFRRTKQEIKSAHKIAKRYSSIPQMWSRCLLRHCYGLWFICLPAYV
Sbjct: 721 KLPSKSSSPNSPLPMFRRTKQEIKSAHKIAKRYSSIPQMWSRCLLRHCYGLWFICLPAYV 780
Query: 781 KVCHSKVRALKTAYDVLKKMQSKKMDPPDEVCYRILMQLCGQYDQPVLAVRVLFEMQKAG 840
KVCHSKVRALKTAYDVLKKMQSKKMDPPDEVCYRILMQLCGQYDQPVLAVRVLFEMQKAG
Sbjct: 781 KVCHSKVRALKTAYDVLKKMQSKKMDPPDEVCYRILMQLCGQYDQPVLAVRVLFEMQKAG 840
Query: 841 IDPNAITYGYYNKAVLESTWPSRSRSGYFLWTKVRNVVLGVTQFKRALKKHAHLSQTTLS 900
IDPNAITYGYYNKAVLESTWPSRSRSGYFLWTKVRNVVLGVTQFKRALKKHAHLSQTTLS
Sbjct: 841 IDPNAITYGYYNKAVLESTWPSRSRSGYFLWTKVRNVVLGVTQFKRALKKHAHLSQTTLS 900
Query: 901 -------------------------------------------GGQSDLGYNSLSKDEVR 917
GGQSDLGYNSLSKDEVR
Sbjct: 901 DGSDLDAVSHGSMDSGHGTHTVEQAPFNTGLIKVYATDDRSSTGGQSDLGYNSLSKDEVR 960
Query: 918 RGDTSTEDIQEEKDKKGSDCSSLSESESTKGSADCLPKLSYQNSSSIVRLTGTSNNSAGK 977
RGDTSTEDIQEEKDKKGSDCSSLSESESTKGSADCLPKLSYQNSSSIVRLTGTSNNSAGK
Sbjct: 961 RGDTSTEDIQEEKDKKGSDCSSLSESESTKGSADCLPKLSYQNSSSIVRLTGTSNNSAGK 1020
Query: 978 ISGESMESTPELLLISSLEDTNETRNIQSRCFRKRHKSDNETNLQQQVVWGNRNRNLSGG 1037
ISGESMESTPELLLISSLEDTNETRNIQSRCFRKRHKSDNETNLQQQVVWGNRNRNLSGG
Sbjct: 1021 ISGESMESTPELLLISSLEDTNETRNIQSRCFRKRHKSDNETNLQQQVVWGNRNRNLSGG 1080
Query: 1038 VLMGFMLNRINQEATPGDIVEKLGADAKILSNVISKSTRPNTLDIGKPPLRSKRDSLEKE 1097
VLMGFMLNRINQEATPGDIVEKLGADAKILSNVISKSTRPNTLDIGKPPLRSKRDSLEKE
Sbjct: 1081 VLMGFMLNRINQEATPGDIVEKLGADAKILSNVISKSTRPNTLDIGKPPLRSKRDSLEKE 1140
Query: 1098 SSDDDTPFDGSNYLADKVDSPVIFDLEDLDSETDVSKAGCVATQNPKRIQRMNSSFSVKP 1157
SSDDDTPFDGSNYLADKVDSPVIFDLEDLDSETDVSKAGCVATQNPKRIQRMNSSFSVKP
Sbjct: 1141 SSDDDTPFDGSNYLADKVDSPVIFDLEDLDSETDVSKAGCVATQNPKRIQRMNSSFSVKP 1200
Query: 1158 FEKTDVATGFDPLSLLVAETEQQQKEEEEEDEDDSKSISTPSARRDLAEEIVMYMNNMSS 1217
FEKTDVATGFDPLSLLVAETEQQQKEEEEEDEDDSKSISTPSARRDLAEEIVMYMNNMSS
Sbjct: 1201 FEKTDVATGFDPLSLLVAETEQQQKEEEEEDEDDSKSISTPSARRDLAEEIVMYMNNMSS 1260
Query: 1218 PLTSRTPSIDLQRACDDKLNKKSPPLVKACRRSSLPPNSPKPVRLTKSKSYTKSEEKPRD 1277
PLTSRTPSIDLQRACDDKLNKKSPPLVKACRRSSLPPNSPKPVRLTKSKSYTKSEEKPRD
Sbjct: 1261 PLTSRTPSIDLQRACDDKLNKKSPPLVKACRRSSLPPNSPKPVRLTKSKSYTKSEEKPRD 1320
Query: 1278 RLWSSPAFSPTCPFREESQDTLTHSSPSFNLDTLLVPKLDVLRNSMFTAGKGVAEKASKW 1337
RLWSSPAFSPTCPFREESQDTLTHSSPSFNLDTLLVPKLDVLRNSMFTAGKGVAEKASKW
Sbjct: 1321 RLWSSPAFSPTCPFREESQDTLTHSSPSFNLDTLLVPKLDVLRNSMFTAGKGVAEKASKW 1380
Query: 1338 YSRFTMYTTSSKDQSSDRTSLSSVGAQDSESTSLTDEDVCHELEGPISSQETSATSGTKR 1397
YSRFTMYTTSSKDQSSDRTSLSSVGAQDSESTSLTDEDVCHELEGPISSQETSATSGTKR
Sbjct: 1381 YSRFTMYTTSSKDQSSDRTSLSSVGAQDSESTSLTDEDVCHELEGPISSQETSATSGTKR 1440
Query: 1398 IDLSRISLESSASLEGSLSKFALPGKSEVTSSFNASNTNIFQNYAMEVLISSCSRCRTCD 1457
IDLSRISLESSASLEGSLSKFALPGKSEVTSSFNASNTNIFQNYAMEVLISSCSRCRTCD
Sbjct: 1441 IDLSRISLESSASLEGSLSKFALPGKSEVTSSFNASNTNIFQNYAMEVLISSCSRCRTCD 1500
Query: 1458 CLVHDEEIMAGWTADDSNLNTTCPFCGNIFLPFLNIEIRDLRRPGRYFLKSSPSTENMHF 1517
CLVHDEEIMAGWTADDSNLNTTCPFCGNIFLPFLNIEIRDLRRPGRYFLKSSPSTENMHF
Sbjct: 1501 CLVHDEEIMAGWTADDSNLNTTCPFCGNIFLPFLNIEIRDLRRPGRYFLKSSPSTENMHF 1560
Query: 1518 PSSISSQTRQSCISTSASGLDTSALSVQGNFDLNSKSKLQENFCTRSIQIPANRSKTAMS 1577
PSSISSQTRQSCISTSASGLDTSALSVQGNFDLNSKSKLQENFCTRSIQIPANRSKTAMS
Sbjct: 1561 PSSISSQTRQSCISTSASGLDTSALSVQGNFDLNSKSKLQENFCTRSIQIPANRSKTAMS 1620
Query: 1578 KCPIFPMARSISTSGPLDKEDTGRQKLISTGSLPATLQGATDSLGLEWHLPSPDPVTVPY 1637
KCPIFPMARSISTSGPLDKEDTGRQKLISTGSLPATLQGATDSLGLEWHLPSPDPVTVPY
Sbjct: 1621 KCPIFPMARSISTSGPLDKEDTGRQKLISTGSLPATLQGATDSLGLEWHLPSPDPVTVPY 1680
Query: 1638 LSPLVVWKELESLLENEGDHAITVADFVDHHPIVFWNLVWYFRRLDLPSNLPGLILSSEH 1697
LSPLVVWKELESLLENEGDHAITVADFVDHHPIVFWNLVWYFRRLDLPSNLPGLILSSEH
Sbjct: 1681 LSPLVVWKELESLLENEGDHAITVADFVDHHPIVFWNLVWYFRRLDLPSNLPGLILSSEH 1740
Query: 1698 CNKYSKIPRHCMSEDSKYVLIQMLWDNMKLHQDPGQPLYILWNAHTQKYPMVHLLQKSDN 1757
CNKYSKIPRHCMSEDSKYVLIQMLWDNMKLHQDPGQPLYILWNAHTQKYPMVHLLQKSDN
Sbjct: 1741 CNKYSKIPRHCMSEDSKYVLIQMLWDNMKLHQDPGQPLYILWNAHTQKYPMVHLLQKSDN 1800
Query: 1758 SFNQELLKSMVKSIKMNDVYGPMSQILETLNKCPHFKRQRSLYREILFLSLVALGRENID 1817
SFNQELLKSMVKSIKMNDVYGPMSQILETLNKCPHFKRQRSLYREILFLSLVALGRENID
Sbjct: 1801 SFNQELLKSMVKSIKMNDVYGPMSQILETLNKCPHFKRQRSLYREILFLSLVALGRENID 1860
Query: 1818 IDAFDKEYKMAYDRLTPSQVKSTHNCDRPPSTGVMECRKTFGEPYL 1863
IDAFDKEYKMAYDRLTPSQVKSTHNCDRPPSTGVMECRKTFGEPYL
Sbjct: 1861 IDAFDKEYKMAYDRLTPSQVKSTHNCDRPPSTGVMECRKTFGEPYL 1906
>gi|94818781 DENN/MADD domain containing 4C [Homo sapiens]
Length = 1673
Score = 1316 bits (3406), Expect = 0.0
Identities = 788/1725 (45%), Positives = 1059/1725 (61%), Gaps = 150/1725 (8%)
Query: 237 MGATIECWPSNSKYPLPVFSTFVLTGASAEKVYGAAIQFYEPYSEENLTEKQRLLLGLTS 296
MGATIECW +KYPLPVFSTFVLTG+SA+KVYGAAIQFYEPYS E L+EKQ + LGL +
Sbjct: 1 MGATIECWDPETKYPLPVFSTFVLTGSSAKKVYGAAIQFYEPYSRELLSEKQLMHLGLLT 60
Query: 297 ADGKSDSSKTIHTNKCICLLSHWPFFDAFRKFLTFLYRYSISGPHVLPIEKHISHFMHKV 356
+ SK+I+TNKCICLLSHWPFF+AFRKFL F+Y+ S+SGPH LPIEKHISHFM +
Sbjct: 61 PVERKMVSKSINTNKCICLLSHWPFFEAFRKFLMFIYKLSVSGPHPLPIEKHISHFMQNI 120
Query: 357 PFPSPQRPRILVQLSPHDNLILSQPVSSPLPLSGGKFSTLLQNLGPENAVTLLVFAVTEH 416
PFPSPQRPRILVQLS HD LILSQPVS+PLPLSG FSTLL NLGPEN TLL+F + E
Sbjct: 121 PFPSPQRPRILVQLSVHDALILSQPVSTPLPLSGANFSTLLMNLGPENCATLLLFVLLES 180
Query: 417 KILIHSLRPSVLTSVTEALVSMIFPFHWPCPYVPLCPLALADVLSAPCPFIVGIDSRYFD 476
KIL+HSLRP+VLT V EA+V+MIFPF W CPY+PLCPL+LA VLSAP PFIVG+DSRYFD
Sbjct: 181 KILLHSLRPAVLTGVAEAVVAMIFPFQWQCPYIPLCPLSLAAVLSAPLPFIVGVDSRYFD 240
Query: 477 LYDPPPDVSCVDVDTNTISQIGDKKNVAWKILPKKPCKNLMNTLNNLHQQLAKLQQRPRD 536
L+DPP DV C+D+DTN + +KKN+ WK LPKKPCKNL++TL L+ QL+ + Q+ ++
Sbjct: 241 LHDPPQDVVCIDLDTNMLYVSDEKKNMNWKQLPKKPCKNLLSTLKKLYPQLSSVHQKTQE 300
Query: 537 DGLMDLAINDYDFNSGKRLHMIDLEIQEAFLFFMASILKGYRSYLRPITQAPSETATDAA 596
+D+ + DF+ K++ +++EIQEAFL FMASILKGYR+YLRPIT+APS AT A
Sbjct: 301 GSAIDMTPIEADFSWQKKMTQLEMEIQEAFLRFMASILKGYRTYLRPITEAPSNKATAAD 360
Query: 597 SLFALQAFLRSRDRSHQKFYNMMTKTQMFIRFIEECSFVSDKDASLAFFDDCV------- 649
SLF Q FL+SRDR++ KFY +++KTQ+FIRFIEECSFVSDKD LAFFDDC+
Sbjct: 361 SLFDRQGFLKSRDRAYAKFYTLLSKTQIFIRFIEECSFVSDKDTGLAFFDDCIEKLFPDK 420
Query: 650 -----DKVDMDKSGEVRLIELDESFKSEHTVFVTPPEIPHLPNGEEPPLQYSYNGFPVLR 704
DKVD D + + RLIELD+S KSEHTVF+ PPE P +G++ +YSY FP L
Sbjct: 421 GTEKTDKVDFDSAEDTRLIELDDSQKSEHTVFIMPPE-PPPDDGKDLSPKYSYKYFPRLD 479
Query: 705 NNLFERPEGFLQAKKNKLPSKSSSPNSPLPMFRRTKQEIKSAHKIAKRYSSIPQMWSRCL 764
LF+RP+ L+ ++ P+ +S SP M +RTKQEIK+AHK+AKR + P W++CL
Sbjct: 480 LKLFDRPQE-LKLCFSRHPTGNSITKSPPLMAKRTKQEIKTAHKLAKRCYTNPPQWAKCL 538
Query: 765 LRHCYGLWFICLPAYVKVCHSKVRALKTAYDVLKKMQSKKMDPPDEVCYRILMQLCGQYD 824
HCY LWFICLPAYV+V H KVRAL+ AYDVL KM+ +DP DEVCYR++MQLCG +
Sbjct: 539 FSHCYSLWFICLPAYVRVSHPKVRALQQAYDVLIKMRKTDVDPLDEVCYRVVMQLCGLWG 598
Query: 825 QPVLAVRVLFEMQKAGIDPNAITYGYYNKAVLESTWPSRSRSGYFLWTKVRNVVLGVTQF 884
PVLAVRVLFEM+ A I PNAITYGYYNK VLES WPS +RSG FLWTKVRNVV G+ QF
Sbjct: 599 HPVLAVRVLFEMKTARIKPNAITYGYYNKVVLESPWPSSTRSGIFLWTKVRNVVRGLAQF 658
Query: 885 KRALKKHAHLSQ-TTLSGGQSDLGYNSLSKDEVRRGDTSTEDIQEE-----------KDK 932
++ LKK SQ +++SGGQSD GY SKDE+ + D +E+ + +
Sbjct: 659 RQPLKKTVQRSQVSSISGGQSDQGYG--SKDELIKDDAEIHVPEEQAARELITKTKMQTE 716
Query: 933 KGSDCSSLSESESTKGSADCLPKLSYQNSSSIVRL-TGTSNNSAGKISGESMESTPELLL 991
+ D S++ S P SSIV++ +G + ++ K S S+ + +
Sbjct: 717 EVCDASAIVAKHSQPSPEPHSPTEPPAWGSSIVKVPSGIFDVNSRKSSTGSISN-----V 771
Query: 992 ISSLEDTNETRNIQSRCFRKRHKSDNETNLQQQVVWGNRNRNLSGGVLMGFMLNRINQEA 1051
+ S +D E K++ E ++Q + R+ + S G +L + + ++
Sbjct: 772 LFSTQDPVEDAVFGEATNLKKNGDRGE---KRQKHFPERSCSFSSESRAGMLLKKSSLDS 828
Query: 1052 TPGDIVEKLGADAKILSNVISKSTRPNTLDIGK-----------PPLRSKRDSLEKESSD 1100
++ +GADAKIL+ ++ + + L I + P R+
Sbjct: 829 NSSEMAIMMGADAKILTAALT-CPKTSLLHIARTHSFENVSCHLPDSRTCMSESTWNPEH 887
Query: 1101 DDTPFDGSNYLADKVDSPVIFDL----------EDLDSETDVSKAGCVATQNPKRIQRMN 1150
+P + ++ PV+ D+ E L S+++ +++ + T + + +
Sbjct: 888 RSSPVPEMLEESQELLEPVVDDVPKTTATVDTYESLLSDSNSNQSRDLKTVSKDLRNKRS 947
Query: 1151 SSFSV-KPFEKTDVATGFDPLSLLVAETEQQQKEEEEEDEDDSKSISTPSARRDLAEEIV 1209
S + + K ++ DV TG DPLSLL E + + E+ + +P R+LA+EI
Sbjct: 948 SLYGIAKVVQREDVETGLDPLSLLATECTGGKTPDSED------KLFSPVIARNLADEIE 1001
Query: 1210 MYMNNMSSPLTSRTPSIDLQRACDDKLNKKSPPLVKACRRSSLPPNSPKPVR-------- 1261
YM N+ SPL S++ S++L R + + + + RRSSLP + P +
Sbjct: 1002 SYM-NLKSPLGSKSSSMELHREENRESGMTTAFIHALERRSSLPLDHGSPAQENPESEKS 1060
Query: 1262 ---LTKSKSYTK--SEEKP----RDRLWSSPAFSPTCPFREESQDTLTHSSPSFNLDTLL 1312
+++SK++T ++ P ++R S A + P S ++ +S LD +L
Sbjct: 1061 SPAVSRSKTFTGRFKQQTPSRTHKERSTSLSALVRSSP--HGSLGSVVNSLSGLKLDNIL 1118
Query: 1313 V-PKLDVLRNSMFTAGKGVAEKASK-WYSRFTMYTTSSKDQSSDRTSLSSVGAQDSESTS 1370
PK+DVL++ M K A ASK W + + Y+ S ++ ++R G +D
Sbjct: 1119 SGPKIDVLKSGM----KQAATVASKMWVAVASAYSYSDDEEETNRDYSFPAGLED----- 1169
Query: 1371 LTDEDVCHELEGPISSQETSATSGTKRIDLSRISLESSASLEGSLSKFALP--------- 1421
H L IS + + + S SL SS+S G + K P
Sbjct: 1170 -------HILGENISPNTSISGLVPSELTQSNTSLGSSSS-SGDVGKLHYPTGEVPFPRG 1221
Query: 1422 ------GKSEVTSSFNASNTNIFQNYAMEVLISSCSRCRTCDCLVHDEEIMAGWTADDSN 1475
KS+ SS N S ++I+QN AMEVL+SSCS+CR C LV+DEEIMAGWTADDSN
Sbjct: 1222 MKGQDFEKSDHGSSQNTSMSSIYQNCAMEVLMSSCSQCRACGALVYDEEIMAGWTADDSN 1281
Query: 1476 LNTTCPFCGNIFLPFLNIEIRDLRRPGRYFLKSSPSTENMHFPSSISSQTRQSCISTSAS 1535
LNT CPFC + FLP LNIE +DLR +FLK PST S +S S
Sbjct: 1282 LNTACPFCKSNFLPLLNIEFKDLRGSASFFLK--PSTSGDSLQSGSIPLANESLEHKPVS 1339
Query: 1536 GLDTSALSVQGNFDLNSKSKLQENFCTRSIQIPANRSKTA--------MSKCP------I 1581
L L +F +++ +E T S P++ K A +S P
Sbjct: 1340 SLAEPDLINFMDFPKHNQIITEE---TGSAVEPSDEIKRASGDVQTMKISSVPNSLSKRN 1396
Query: 1582 FPMARSISTSGPLDKEDTGRQKL--ISTGSLPATLQGATDSLGLEWHLPSPDPVTVPYLS 1639
+ RS S GPL D ++ IST SLP +LQ D LG P+P PV+VPYLS
Sbjct: 1397 VSLTRSHSVGGPLQNIDFTQRPFHGISTVSLPNSLQEVVDPLGKR---PNPPPVSVPYLS 1453
Query: 1640 PLVVWKELESLLENEGDHAITVADFVDHHPIVFWNLVWYFRRLDLPSNLPGLILSSEHCN 1699
PLV+ KELESLLENEGD I + F++ HPI+FWNLVWYFRRLDLPSNLPGLIL+SEHCN
Sbjct: 1454 PLVLRKELESLLENEGDQVIHTSSFINQHPIIFWNLVWYFRRLDLPSNLPGLILTSEHCN 1513
Query: 1700 KYSKIPRHCMSEDSKYVLIQMLWDNMKLHQDPGQPLYILW-NAHTQKYPMVHLLQKSDNS 1758
+ ++P +S+DSK V IQ+LWDN+ LHQ+P +PLY+ W N +++K + ++ + S
Sbjct: 1514 EGVQLPLSSLSQDSKLVYIQLLWDNINLHQEPREPLYVSWRNFNSEKKSSLLSEEQQETS 1573
Query: 1759 FNQELLKSMVKSIKMNDVYGPMSQILETLNKCPHFKRQRSLYREILFLSLVALGRENIDI 1818
L++++ +SI+ N+V P++ + + + P KRQRSLYREILFLSLV+LGRENIDI
Sbjct: 1574 ---TLVETIRQSIQHNNVLKPINLLSQQMK--PGMKRQRSLYREILFLSLVSLGRENIDI 1628
Query: 1819 DAFDKEYKMAYDRLTPSQVKSTHNCDRPPSTGVMECRKTFGEPYL 1863
+AFD EY +AY+ L+ ++ D PPS V CRK FG P +
Sbjct: 1629 EAFDNEYGIAYNSLSSEILERLQKIDAPPSASVEWCRKCFGAPLI 1673
>gi|148922920 DENN/MADD domain containing 4B [Homo sapiens]
Length = 1496
Score = 1041 bits (2691), Expect = 0.0
Identities = 516/906 (56%), Positives = 660/906 (72%), Gaps = 17/906 (1%)
Query: 1 MIEDKGPRVADYFVVAGLTDVSKPLEEEIHFNDACHKVAKPK--EPITDVSVIIKSLGEE 58
M E++ PR+ DYFVVAGL P+ EE + + P+ EPITDV+VI ++LGEE
Sbjct: 1 MAEERPPRLVDYFVVAGLAGNGAPIPEETWVPEPSGPLRPPRPAEPITDVAVIARALGEE 60
Query: 59 VPQDYICIDVTPTGLSADLNNGSLVGPQIYLCYRRGRDKPPLTDLGVLYDWKERLKQGCE 118
VPQ Y CI + G +L+ G L G Q +CYRRGRDKPPL +LGVLY+ KER K G +
Sbjct: 61 VPQGYTCIQASAGGHPLELSAGLLGGTQPVICYRRGRDKPPLVELGVLYEGKERPKPGFQ 120
Query: 119 IIQSTPYGRPANISG-STSSQRIYITYRRASENMTQNTLAVTDICIIIPSKGESPPHTFC 177
++ +TPY AN++ R Y+TYRRA+E + L +TD+C+++PSKGE PHT+C
Sbjct: 121 VLDTTPYSHSANLAPPGPGHPRTYLTYRRAAEGAGLHALGITDLCLVLPSKGEGTPHTYC 180
Query: 178 KVDKNLNNSMWGSAVYLCYKKSVAKTNTVSYKAGLICRYPQEDYESFSLPESVPLFCLPM 237
++ +NLN MWG AVYLCYK +AK NT+ Y+A L+ RYP+ED E+F LPESVP+FCLPM
Sbjct: 181 RLPRNLNPGMWGPAVYLCYKVGLAKANTLVYEAELLGRYPEEDNEAFPLPESVPVFCLPM 240
Query: 238 GATIECWPSNSKYPLPVFSTFVLTGASAEKVYGAAIQFYEPYSEENLTEKQRLLLGLTSA 297
GATIECWP+ +KYP+PVFSTFVLTGA+ +KVYGAA+QFYE + L+E+Q LGL SA
Sbjct: 241 GATIECWPAQTKYPVPVFSTFVLTGAAGDKVYGAALQFYEAFPRARLSERQARALGLLSA 300
Query: 298 --DGKSDSSKTIHTNKCICLLSHWPFFDAFRKFLTFLYRYSISGPHVLPIEKHISHFMHK 355
G++ + + + + I +LS WP F AFR FLTFLYRYS+SGPH LP+E HISHF+H
Sbjct: 301 VERGRALGGRAVRSRRAIAVLSRWPAFPAFRAFLTFLYRYSVSGPHRLPLEAHISHFIHN 360
Query: 356 VPFPSPQRPRILVQLSPHDNLILSQPVSSPLPLSGGKFSTLLQNLGPENAVTLLVFAVTE 415
VPFPSPQRPRILVQ+SP+DNL+L QPVSSPLPLSG F LLQ+LGPE A+TLL+ +TE
Sbjct: 361 VPFPSPQRPRILVQMSPYDNLLLCQPVSSPLPLSGASFLQLLQSLGPELAITLLLAVLTE 420
Query: 416 HKILIHSLRPSVLTSVTEALVSMIFPFHWPCPYVPLCPLALADVLSAPCPFIVGIDSRYF 475
HK+L+HSLRP +LTSV EALVSMIFP HW CPY+PLCPL LADVLSAP PFIVGI S YF
Sbjct: 421 HKLLVHSLRPDLLTSVCEALVSMIFPLHWQCPYIPLCPLVLADVLSAPVPFIVGIHSSYF 480
Query: 476 DLYDPPPDVSCVDVDTNTISQIGDKKNVAWKILPKKPCKNLMNTLNNLHQQLAKLQQRPR 535
DL+DPP DV CVD+DTNT+ Q +KK ++ + LP++P K L+ TL NL+QQL + P
Sbjct: 481 DLHDPPADVICVDLDTNTLFQTEEKKLLSPRTLPRRPYKVLLATLTNLYQQLDQTYTGPE 540
Query: 536 DDGLMDLAINDYDFNSGKRLHMIDLEIQEAFLFFMASILKGYRSYLRPITQAPSETATDA 595
++ ++ + DY+ G+R ++ E+Q AFL FMA +LKGYR +LRP+TQAPSE A D
Sbjct: 541 EEASLEFLLTDYEAVCGRRAR-LEREVQGAFLRFMACLLKGYRVFLRPLTQAPSEGARDV 599
Query: 596 ASLFALQAFLRSRDRSHQKFYNMMTKTQMFIRFIEECSFVSDKDASLAFFDDCVDKV--D 653
+LF LQ FL+SR+RS K Y+ + TQMF +FIEECSF S + A+L FFD CV+KV +
Sbjct: 600 DNLFFLQGFLKSRERSSHKLYSQLLHTQMFSQFIEECSFGSARHAALEFFDSCVEKVHPE 659
Query: 654 MDKSGEVRLIELDESFKSEHTVFVTPPEIPHLPNGEEPPLQYSYNGFPVLRNNLFERPEG 713
+K L+EL+E SE TVF+TPPE P LP G E QY Y+GFP LR LFE
Sbjct: 660 QEKPEPTPLVELEELSGSELTVFITPPEEPALPEGSESTPQYCYDGFPELRAELFES--- 716
Query: 714 FLQAKKNKLP---SKSSSPNSPLPMFRRTKQEIKSAHKIAKRYSSIPQMWSRCLLRHCYG 770
LQ + LP S+P+SP P RRTKQE+K A ++A++ +++P++W+RCLL HCYG
Sbjct: 717 -LQEQPGALPVPGPSRSAPSSPAP--RRTKQEMKVAQRMAQKSAAVPELWARCLLGHCYG 773
Query: 771 LWFICLPAYVKVCHSKVRALKTAYDVLKKMQSKKMDPPDEVCYRILMQLCGQYDQPVLAV 830
LWF+CLPAYV+ S+V+AL TAY VL++M+S K+ PDEVCYR+LMQLC Y QPVL+V
Sbjct: 774 LWFLCLPAYVRSAPSRVQALHTAYHVLRQMESGKVVLPDEVCYRVLMQLCSHYGQPVLSV 833
Query: 831 RVLFEMQKAGIDPNAITYGYYNKAVLESTWPSRSRSGYFLWTKVRNVVLGVTQFKRALKK 890
RV+ EM++AGI PN ITYGYYNKAVLES WPS + G W K+RNVVLG QF++ L++
Sbjct: 834 RVMLEMRQAGIVPNTITYGYYNKAVLESKWPSGTPGGRLRWAKLRNVVLGAAQFRQPLRE 893
Query: 891 HAHLSQ 896
Q
Sbjct: 894 RQQQQQ 899
Score = 179 bits (455), Expect = 2e-44
Identities = 95/228 (41%), Positives = 142/228 (62%), Gaps = 3/228 (1%)
Query: 1637 YLSPLVVWKELESLLENEGDHAITVADFVDHHPIVFWNLVWYFRRLDLPSNLPGLILSSE 1696
YLSPLV+ KELESL+ENEG + + + HPI+FWNL+WYF+RL LPS LPGL+L+S
Sbjct: 1266 YLSPLVLRKELESLVENEGSEVLALPELPSAHPIIFWNLLWYFQRLRLPSILPGLVLASC 1325
Query: 1697 HCNKYSKIPRHCMSEDSKYVLIQMLWDNMKLHQDPGQPLYILWNAHTQKYPMVHLLQKSD 1756
+S+ P ++ D V +++LWD + + PLY+LW H+Q V
Sbjct: 1326 DGPSHSQAPSPWLTPDPASVQVRLLWDVLTPDPNSCPPLYVLWRVHSQIPQRVVWPGPVP 1385
Query: 1757 NSFNQELLKSMVKSIKMNDVYGPMSQILETLNKCP-HFKRQRSLYREILFLSLVALGREN 1815
S + LL+S+++ + +N+V+ + +LETL P QR +YREILFL++ ALG+++
Sbjct: 1386 ASLSLALLESVLRHVGLNEVHKAVGLLLETLGPPPTGLHLQRGIYREILFLTMAALGKDH 1445
Query: 1816 IDIDAFDKEYKMAYDRLTPSQVKS--THNCDRPPSTGVMECRKTFGEP 1861
+DI AFDK+YK A+++L S K H + P+ ++CRK FG P
Sbjct: 1446 VDIVAFDKKYKSAFNKLASSMGKEELRHRRAQMPTPKAIDCRKCFGAP 1493
Score = 99.4 bits (246), Expect = 3e-20
Identities = 54/97 (55%), Positives = 67/97 (69%), Gaps = 3/97 (3%)
Query: 1406 ESSASL--EGSLSKFALPGKSEVTSSFNASNT-NIFQNYAMEVLISSCSRCRTCDCLVHD 1462
ESSASL E LS+ +L S SS S+T FQ+ ++E+L+SSCS CR CD LV+D
Sbjct: 1110 ESSASLGSEWDLSESSLSNLSLRRSSERLSDTPGSFQSPSLEILLSSCSLCRACDSLVYD 1169
Query: 1463 EEIMAGWTADDSNLNTTCPFCGNIFLPFLNIEIRDLR 1499
EEIMAGW DDSNLNTTCPFC F+P L+++ D R
Sbjct: 1170 EEIMAGWAPDDSNLNTTCPFCACPFVPLLSVQTLDSR 1206
>gi|29788755 SET binding factor 2 [Homo sapiens]
Length = 1849
Score = 137 bits (345), Expect = 1e-31
Identities = 122/475 (25%), Positives = 208/475 (43%), Gaps = 47/475 (9%)
Query: 212 LICRYPQEDYESFSLPESVPLFCLPMGATIECWPSNSKYPLPVFSTFVLTGASAEKVYGA 271
+I R+PQ+D++ P+ + LFC P G W + + P F VLT +++ Y +
Sbjct: 27 IIQRFPQKDWDDTPFPQGIELFCQPGG-----WQLSRERKQPTFFVVVLTDIDSDRHYCS 81
Query: 272 AIQFYEPYSEENLTEKQRLLLGLTSADGKSDSSKTIHTNKCICLLSHWPFFDAFRKFLTF 331
+ FYE T+K+ + G G ++ + K + L+S + + FR L
Sbjct: 82 CLTFYEAEINLQGTKKEEIE-GEAKVSGLIQPAE-VFAPKSLVLVSRLYYPEIFRACLGL 139
Query: 332 LYRYSISGPHVLPIEKHISHFMHKVPFPSPQRPRILVQLSPHDNLILSQPVSSPLPLSGG 391
+Y + +V +E I++ + P+ + L L D ++ P+ LP++G
Sbjct: 140 IYTVYVDSLNV-SLESLIANLCACL-VPAAGGSQKLFSLGAGDRQLIQTPLHDSLPITGT 197
Query: 392 KFSTLLQNLGPENAVTLLVFAVTEHKILIHSLRPSVLTSVTEALVSMIFPFHWPCPYVPL 451
+ L Q LG +N ++L +TE+K+L HS L+ AL S++FP + PY+P+
Sbjct: 198 SVALLFQQLGIQNVLSLFCAVLTENKVLFHSASFQRLSDACRALESLMFPLKYSYPYIPI 257
Query: 452 CPLALADVLSAPCPFIVGIDSRYFDLYDPPPDVSCVDVDTNTISQIGDKKNVAWKILPKK 511
P L +VLS+P PFI+G+ S + DV D+D TI KI
Sbjct: 258 LPAQLLEVLSSPTPFIIGVHSVFKTDVHELLDVIIADLDGGTI-----------KIPECI 306
Query: 512 PCKNLMNTLNNLHQQLAKLQQRPRDDGLMDLAINDYDF----NSGKRLHMIDLEIQEAFL 567
+L L + Q L P DL + D+ F + M+D E++ FL
Sbjct: 307 HLSSLPEPLLHQTQSALSLILHP------DLEVADHAFPPPRTALSHSKMLDKEVRAVFL 360
Query: 568 FFMASILKGYRSYLRPITQAPSETATDAASLFALQAFLRSRDRSHQKFYNMMTKTQMFIR 627
A + +GYRS L+ I + F AFL R F + F
Sbjct: 361 RLFAQLFQGYRSCLQLI-----RIHAEPVIHFHKTAFLGQRGLVENDFLTKVLSGMAFAG 415
Query: 628 FIEECSFVSDKDASLAFFDDC----VDKVDMDKSGEVRLIE-----LDESFKSEH 673
F+ E S FD+ V+++ ++++ V++I+ ++ FK+E+
Sbjct: 416 FVSE---RGPPYRSCDLFDELVAFEVERIKVEENNPVKMIKHVRELAEQLFKNEN 467
>gi|122891862 DENN/MADD domain containing 5B [Homo sapiens]
Length = 1274
Score = 133 bits (335), Expect = 1e-30
Identities = 128/550 (23%), Positives = 226/550 (41%), Gaps = 111/550 (20%)
Query: 207 SYKAGLICRYPQE-DYESFSLPESVPLFCLPMGATIECWPSNSKYPLPVFSTFVLTGASA 265
++K+ ++ YPQ ++ F ++V + C+P G + N P F +F++T
Sbjct: 54 TFKSKVLAHYPQNIEWNPFD-QDAVNMLCMPKGLSFRTQTDNKD---PQFHSFIITREDG 109
Query: 266 EKVYGAAIQFYEPYSEENLTEKQRLLLGLTSADGKSD----------------------- 302
+ YG + FYE + + + + L + +A+ S
Sbjct: 110 SRTYGFVLTFYEEVTSKQICTAMQTLYQMHNAEHYSSVYASSSCSMDSLASSLDEGDTTS 169
Query: 303 ------------SSKTIHTNKCICLLSHWPFFDAFRKFLTFLYRYSISG-PHVLPIEKHI 349
S T++ +K ICL++ PF A +KFL LY+ S P LP+E +I
Sbjct: 170 LLKLQRYNSYDISRDTLYVSKSICLITPLPFMQACKKFLIQLYKAVTSQQPPPLPLESYI 229
Query: 350 SHFMHKVPFPSPQRPRILVQLSPHDNLILSQPVSSPLPLSGGKFSTLLQNLGPENAVTLL 409
+ +++VP P P R L ++ +I +P S LPLS + LG EN V +
Sbjct: 230 HNILYEVPLPPPGRS--LKFYGVYEPVICQRPGPSELPLSDYPLREAFELLGLENLVQVF 287
Query: 410 VFAVTEHKILIHSLRPSVLTSVTEALVSMIFPFHWPCPYVPLCPLALADVLSAPCPFIVG 469
+ E +IL++S L +V E + +++FPF W YVP+ P +L L AP P+++G
Sbjct: 288 TCVLLEMQILLYSQDYQRLMTVAEGITTLLFPFQWQHVYVPILPASLLHFLDAPVPYLMG 347
Query: 470 ------------------------IDSRYFDLYDP----PPDVSCVDVDTNTISQIG--- 498
ID+ + +L + P V + + + Q G
Sbjct: 348 LQSKEGTDRSKLELPQEANLCFVDIDNHFIELPEEFPQFPNKVDFIQELSEVLVQFGIPP 407
Query: 499 -----------DKKNVAWKILPKKPCKNLMNTLNNL--------HQQLAKLQQRPRDDGL 539
KN+ K L KN NN+ ++ +A+LQ + G+
Sbjct: 408 EGSLHCSESTSKLKNMVLKDLVNDK-KNGNVCTNNISMYELLKGNETIARLQALAKRTGV 466
Query: 540 ----MDLAINDYDFNSGKRLH---------MIDLEIQEAFLFFMASILKGYRSYLRPITQ 586
MDL+ + + + +LH ++++++E F + Y +++ Q
Sbjct: 467 AVEKMDLSASLGEKDKDLKLHCEEAELRDYQLNVQLREVFANRFTQMFADYEAFVIQTAQ 526
Query: 587 APSETATDAASL--FALQAFLRSRDRSHQKFYNMMTKTQMFIRFIEE--CSFVSDKDASL 642
T+ + F +FL + + F + +TQMF FI+ S +KD L
Sbjct: 527 DMESWLTNREQMQNFDKASFLSDQPEPYLPFLSRFIETQMFATFIDNKIMSQWEEKDPLL 586
Query: 643 AFFDDCVDKV 652
FD +DK+
Sbjct: 587 RVFDTRIDKI 596
>gi|44889475 RAB6 interacting protein 1 [Homo sapiens]
Length = 1287
Score = 127 bits (319), Expect = 1e-28
Identities = 151/664 (22%), Positives = 263/664 (39%), Gaps = 150/664 (22%)
Query: 207 SYKAGLICRYPQE-DYESFSLPESVPLFCLPMGATIECWPSNSKYPLPVFSTFVLTGASA 265
++K+ ++ RYP+ ++ F ++V + C+P G + + P F F++T
Sbjct: 72 TFKSKVLARYPENVEWNPFD-QDAVGMLCMPKGLAFKTQADPRE---PQFHAFIITREDG 127
Query: 266 EKVYGAAIQFYEPYSEENLTEKQRLL----------LGLTSADGKSDSSK---------- 305
+ +G A+ FYE + + + + L L AD + SS
Sbjct: 128 SRTFGFALTFYEEVTSKQICSAMQTLYHMHNAEYDVLHAPPADDRDQSSMEDGEDTPVTK 187
Query: 306 ------------TIHTNKCICLLSHWPFFDAFRKFLTFLYRYSISG-PHVLPIEKHISHF 352
T++ +KCICL++ F A R L L++ S P LP+E +I +
Sbjct: 188 LQRFNSYDISRDTLYVSKCICLITPMSFMKACRSVLEQLHQAVTSPQPPPLPLESYIYNV 247
Query: 353 MHKVPFPSPQRPRILVQLSPHDNLILSQPVSSPLPLSGGKFSTLLQNLGPENAVTLLVFA 412
+++VP P P R L + +I +P ++ LPL + + LG EN L A
Sbjct: 248 LYEVPLPPPGRS--LKFSGVYGPIICQRPSTNELPLFDFPVKEVFELLGVENVFQLFTCA 305
Query: 413 VTEHKILIHSLRPSVLTSVTEALVSMIFPFHWPCPYVPLCPLALADVLSAPCPFIVGIDS 472
+ E +IL++S L +V E + +++FPF W YVP+ P +L L AP P+++G+ S
Sbjct: 306 LLEFQILLYSQHYQRLMTVAETITALMFPFQWQHVYVPILPASLLHFLDAPVPYLMGLHS 365
Query: 473 RYFD----LYDPPPDVSC-VDVDTNTISQIGDKKN---------------VAWKILPK-- 510
D L P C VD+D + I D +A+ I P+
Sbjct: 366 NGLDDRSKLELPQEANLCFVDIDNHFIELPEDLPQFPNKLEFVQEVSEILMAFGIPPEGN 425
Query: 511 KPCKNLMNTLNNL---------------------------HQQLAKLQQRPRDDG--LMD 541
C + L L ++ +A+LQ + G L
Sbjct: 426 LHCSESASKLKRLRASELVSDKRNGNIAGSPLHSYELLKENETIARLQALVKRTGVSLEK 485
Query: 542 LAINDYDFNSGKRL-----------HMIDLEIQEAFLFFMASILKGYRSYLRPITQAPSE 590
L + + D +S K L + ++++I+E F + Y ++ +Q
Sbjct: 486 LEVRE-DPSSNKDLKVQCDEEELRIYQLNIQIREVFANRFTQMFADYEVFVIQPSQDKES 544
Query: 591 TATDAASL--FALQAFLRSRDRSHQKFYNMMTKTQMFIRFIEE---CSFVSDKDASLAFF 645
T+ + F +FL + + F + +TQMF FI+ C DKD L F
Sbjct: 545 WFTNREQMQNFDKASFLSDQPEPYLPFLSRFLETQMFASFIDNKIMCHDDDDKDPVLRVF 604
Query: 646 DDCVDKV----------------------DMDKSGEVRLIELDESFKSEHTVFVTPPEIP 683
D VDK+ + +K+ E+RL ++D HT P
Sbjct: 605 DSRVDKIRLLNVRTPTLRTSMYQKCTTVDEAEKAIELRLAKID------HTAI-----HP 653
Query: 684 HLPNGEEPPLQYSYNGFPVLRNNLFERPEGFLQAKKNKLPSKSSSPNSPLPMFRRTKQEI 743
HL + + +Y FP L++++ +K + N+P R+ +Q+
Sbjct: 654 HLLDMKIGQGKYEPGFFPKLQSDVL---------STGPASNKWTKRNAPAQWRRKDRQKQ 704
Query: 744 KSAH 747
+ H
Sbjct: 705 HTEH 708
>gi|239735519 SET binding factor 1 [Homo sapiens]
Length = 1893
Score = 125 bits (313), Expect = 5e-28
Identities = 109/437 (24%), Positives = 180/437 (41%), Gaps = 49/437 (11%)
Query: 212 LICRYPQEDYESFSLPESVPLFCLPMGATIECWPSNSKYPLPVFSTFVLTGASAEKVYGA 271
++ R+P++D+E P+ + LFC P G W + P F VLT ++E+ Y A
Sbjct: 27 ILQRFPEKDWEDNPFPQGIELFCQPSG-----WQLCPERNPPTFFVAVLTDINSERHYCA 81
Query: 272 AIQFYEPYSEENLTEKQRLLLGLTSADGKSDSSKTIHTN-------------KCICLLSH 318
+ F+EP T + T + + D H + K + L+S
Sbjct: 82 CLTFWEPAEPSQETTRVE---DATEREEEGDEGGQTHLSPTAPAPSAQLFAPKTLVLVSR 138
Query: 319 WPFFDAFRKFLTFLYRYSISGPHVLPIEKHISHFMHKVPFPSPQRPRILVQLSPHDNLIL 378
+ FR L +Y + G +V +E I + + P + + L D ++
Sbjct: 139 LDHTEVFRNSLGLIYAIHVEGLNVC-LENVIGNLL-TCTVPLAGGSQRTISLGAGDRQVI 196
Query: 379 SQPVSSPLPLSGGKFSTLLQNLGPENAVTLLVFAVTEHKILIHSLRPSVLTSVTEALVSM 438
P++ LP+S + L + LG N ++L A+TEHK+L S L L+++
Sbjct: 197 QTPLADSLPVSRCSVALLFRQLGITNVLSLFCAALTEHKVLFLSRSYQRLADACRGLLAL 256
Query: 439 IFPFHWPCPYVPLCPLALADVLSAPCPFIVGIDSRYFDLYDPPPDVSCVDVDTNTISQIG 498
+FP + YVP+ P L +VLS P PFI+G+++ + DV D+D T++
Sbjct: 257 LFPLRYSFTYVPILPAQLLEVLSTPTPFIIGVNAAFQAETQELLDVIVADLDGGTVT--- 313
Query: 499 DKKNVAWKILPKKPCKNLMNTLNNLHQQLAKLQQRPRDDGLMDLAINDYDF----NSGKR 554
+P+ C ++ L Q + D +L + D F S
Sbjct: 314 ---------IPE--CVHIPPLPEPLQSQTHSVLSMVLDP---ELELADLAFPPPTTSTSS 359
Query: 555 LHMIDLEIQEAFLFFMASILKGYRSYLRPITQAPSETATDAASLFALQAFLRSRDRSHQK 614
L M D E++ FL A +L+GYR L + P + F AFL R
Sbjct: 360 LKMQDKELRAVFLRLFAQLLQGYRWCLHVVRIHP-----EPVIRFHKAAFLGQRGLVEDD 414
Query: 615 FYNMMTKTQMFIRFIEE 631
F + + F F+ E
Sbjct: 415 FLMKVLEGMAFAGFVSE 431
>gi|21361991 DENN/MADD domain containing 2D [Homo sapiens]
Length = 471
Score = 90.5 bits (223), Expect = 1e-17
Identities = 103/427 (24%), Positives = 175/427 (40%), Gaps = 82/427 (19%)
Query: 213 ICRYPQEDYESFSLPESVPLFCLPMGATIECWPSNSKYPLPVFSTFVLTGASAEKVYGAA 272
+ R QE+ E L +++PLFC P G W S ++YP FS FVLT + G
Sbjct: 85 LLRGQQEEEER--LLKAIPLFCFPDGNE---WASLTEYPRETFS-FVLTNVDGSRKIGYC 138
Query: 273 IQFYEPYSEENLTEKQRLLLGLTSADGKSDSSKTIHTNKCICLLSHWPFFDAFRKFLTFL 332
+RLL + K C++S F F K L +
Sbjct: 139 ---------------RRLL----------PAGPGPRLPKVYCIISCIGCFGLFSKILDEV 173
Query: 333 Y-RYSISGPHVLPIEKHISHFMHKVPFPSPQRPRILVQLSPHDN---LILSQPVSSPLPL 388
R+ IS + P + + + FP+P + L P + L++P+ S L
Sbjct: 174 EKRHQISMAVIYPFMQGL----REAAFPAPGKTVTLKSFIPDSGTEFISLTRPLDSHL-- 227
Query: 389 SGGKFSTLLQNLGPENAVTLLVFAVTEHKILIHSLRPSVLTSVTEALVSMIFPFHWPCPY 448
FS+LL L E + + AV E KI+ + S L+ A ++++PF W Y
Sbjct: 228 EHVDFSSLLHCLSFEQILQIFASAVLERKIIFLAEGLSTLSQCIHAAAALLYPFSWAHTY 287
Query: 449 VPLCPLALADVLSAPCPFIVGIDSRYFD--LYDPPPDVSCVDVDTNT-ISQIGDKKNVAW 505
+P+ P +L + P PF+VG+ R+ + P +V V++ T + +GD+K+
Sbjct: 288 IPVVPESLLATVCCPTPFMVGVQMRFQQEVMDSPMEEVLLVNLCEGTFLMSVGDEKD--- 344
Query: 506 KILPKKPCKNLMNTLNNLHQQLAKLQQRPRDDGLMDLAINDYDFNSGKRLHMIDLEIQEA 565
ILP K +++++L N K I+ +
Sbjct: 345 -ILPPKLQDDILDSLGQ-------------------------GINELKTAEQINEHVSGP 378
Query: 566 FLFFMASILKGYRSYLRPITQAPSETATDAASLFALQAFLRS-RDRSHQKFYNMMTKTQM 624
F+ F I+ Y SY++ + F ++F ++ +++++F KTQ+
Sbjct: 379 FVQFFVKIVGHYASYIK--------REANGQGHFQERSFCKALTSKTNRRFVKKFVKTQL 430
Query: 625 FIRFIEE 631
F FI+E
Sbjct: 431 FSLFIQE 437
>gi|209863002 MAP-kinase activating death domain-containing protein
isoform j [Homo sapiens]
Length = 1541
Score = 89.7 bits (221), Expect = 2e-17
Identities = 125/533 (23%), Positives = 203/533 (38%), Gaps = 123/533 (23%)
Query: 203 TNTVSYKAGLICRYPQEDYESFSLPESVPLFCLPMGATIECWPSNSKYPLPVFSTFVLTG 262
+++V+ L+ RYP ED+ F LP V FC P G + L ++FV T
Sbjct: 25 SDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEGCLSV---RQRRMSLRDDTSFVFTL 81
Query: 263 ASAEKV---YGAAIQFYEPY--------------------------SEENLTEKQRLLLG 293
+ YG + FY + SEE TE
Sbjct: 82 TDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKEGTHATCASEEGGTESSESGSS 141
Query: 294 LT--SADG--------------KSDSSKTIHTNKCICLLSHWPFFDAFRKFLTFLYRY-- 335
L SAD K+ S T +C+LSH+PFF FR+ L L R
Sbjct: 142 LQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVLSHYPFFSTFRECLYTLKRLVD 201
Query: 336 ----SISGPHV------------------LPIEKHISHFMHKV-------------PFPS 360
+ G + L +E+ S +H + P P
Sbjct: 202 CCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSALLHDLREIEAWIYRLLRSPVPV 261
Query: 361 PQRPRILVQLSPHD---NLILSQPVSSPLPLSGGKFSTLLQNLGPENAVTLLVFAVTEHK 417
+ R+ +++ P + L + P S L L+ LG + + +L + EHK
Sbjct: 262 SGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVLTCILLEHK 321
Query: 418 ILIHSLRPSVLTSVTEALVSMIFPFHWPCPYVPLCPLALA---DVLSAPCPFIVGIDSRY 474
+++ S + L+ A V+MI+P + P +PL P +A +L AP P+I+G+ + +
Sbjct: 322 VVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASF 381
Query: 475 FDL---YDPPPDVSCVDVDTNTISQIGDKKNVAWKILP-------KKPCKNLMNTLN--- 521
F + P DV VD+D+N + I ILP KK K + +++
Sbjct: 382 FLYKLDFKMPDDVWLVDLDSNRV--IAPTNAEVLPILPEPESLELKKHLKQALASMSLNT 439
Query: 522 ----NLH-----QQLAKLQQRPRDDGLMDLAINDYDFNSGKRLHMIDLEIQEAFLFFM-- 570
NL Q++ L RP +D + G + +D+ + A + F
Sbjct: 440 QPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGNDVDSVDVATRVAMVRFFNS 499
Query: 571 ASILKGYRSYLRPITQAPSETATDAASLFALQAFLRSRDRSHQKFYNMMTKTQ 623
A++L+G++ + R + P F +FL SR R F + +TQ
Sbjct: 500 ANVLQGFQMHTRTLRLFPRPVVA-----FQAGSFLASRPR-QTPFAEKLARTQ 546
>gi|209862998 MAP-kinase activating death domain-containing protein
isoform i [Homo sapiens]
Length = 1544
Score = 89.7 bits (221), Expect = 2e-17
Identities = 125/533 (23%), Positives = 203/533 (38%), Gaps = 123/533 (23%)
Query: 203 TNTVSYKAGLICRYPQEDYESFSLPESVPLFCLPMGATIECWPSNSKYPLPVFSTFVLTG 262
+++V+ L+ RYP ED+ F LP V FC P G + L ++FV T
Sbjct: 25 SDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEGCLSV---RQRRMSLRDDTSFVFTL 81
Query: 263 ASAEKV---YGAAIQFYEPY--------------------------SEENLTEKQRLLLG 293
+ YG + FY + SEE TE
Sbjct: 82 TDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKEGTHATCASEEGGTESSESGSS 141
Query: 294 LT--SADG--------------KSDSSKTIHTNKCICLLSHWPFFDAFRKFLTFLYRY-- 335
L SAD K+ S T +C+LSH+PFF FR+ L L R
Sbjct: 142 LQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVLSHYPFFSTFRECLYTLKRLVD 201
Query: 336 ----SISGPHV------------------LPIEKHISHFMHKV-------------PFPS 360
+ G + L +E+ S +H + P P
Sbjct: 202 CCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSALLHDLREIEAWIYRLLRSPVPV 261
Query: 361 PQRPRILVQLSPHD---NLILSQPVSSPLPLSGGKFSTLLQNLGPENAVTLLVFAVTEHK 417
+ R+ +++ P + L + P S L L+ LG + + +L + EHK
Sbjct: 262 SGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVLTCILLEHK 321
Query: 418 ILIHSLRPSVLTSVTEALVSMIFPFHWPCPYVPLCPLALA---DVLSAPCPFIVGIDSRY 474
+++ S + L+ A V+MI+P + P +PL P +A +L AP P+I+G+ + +
Sbjct: 322 VVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASF 381
Query: 475 FDL---YDPPPDVSCVDVDTNTISQIGDKKNVAWKILP-------KKPCKNLMNTLN--- 521
F + P DV VD+D+N + I ILP KK K + +++
Sbjct: 382 FLYKLDFKMPDDVWLVDLDSNRV--IAPTNAEVLPILPEPESLELKKHLKQALASMSLNT 439
Query: 522 ----NLH-----QQLAKLQQRPRDDGLMDLAINDYDFNSGKRLHMIDLEIQEAFLFFM-- 570
NL Q++ L RP +D + G + +D+ + A + F
Sbjct: 440 QPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGNDVDSVDVATRVAMVRFFNS 499
Query: 571 ASILKGYRSYLRPITQAPSETATDAASLFALQAFLRSRDRSHQKFYNMMTKTQ 623
A++L+G++ + R + P F +FL SR R F + +TQ
Sbjct: 500 ANVLQGFQMHTRTLRLFPRPVVA-----FQAGSFLASRPR-QTPFAEKLARTQ 546
>gi|209862994 MAP-kinase activating death domain-containing protein
isoform d [Homo sapiens]
Length = 1647
Score = 89.7 bits (221), Expect = 2e-17
Identities = 125/533 (23%), Positives = 203/533 (38%), Gaps = 123/533 (23%)
Query: 203 TNTVSYKAGLICRYPQEDYESFSLPESVPLFCLPMGATIECWPSNSKYPLPVFSTFVLTG 262
+++V+ L+ RYP ED+ F LP V FC P G + L ++FV T
Sbjct: 25 SDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEGCLSV---RQRRMSLRDDTSFVFTL 81
Query: 263 ASAEKV---YGAAIQFYEPY--------------------------SEENLTEKQRLLLG 293
+ YG + FY + SEE TE
Sbjct: 82 TDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKEGTHATCASEEGGTESSESGSS 141
Query: 294 LT--SADG--------------KSDSSKTIHTNKCICLLSHWPFFDAFRKFLTFLYRY-- 335
L SAD K+ S T +C+LSH+PFF FR+ L L R
Sbjct: 142 LQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVLSHYPFFSTFRECLYTLKRLVD 201
Query: 336 ----SISGPHV------------------LPIEKHISHFMHKV-------------PFPS 360
+ G + L +E+ S +H + P P
Sbjct: 202 CCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSALLHDLREIEAWIYRLLRSPVPV 261
Query: 361 PQRPRILVQLSPHD---NLILSQPVSSPLPLSGGKFSTLLQNLGPENAVTLLVFAVTEHK 417
+ R+ +++ P + L + P S L L+ LG + + +L + EHK
Sbjct: 262 SGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVLTCILLEHK 321
Query: 418 ILIHSLRPSVLTSVTEALVSMIFPFHWPCPYVPLCPLALA---DVLSAPCPFIVGIDSRY 474
+++ S + L+ A V+MI+P + P +PL P +A +L AP P+I+G+ + +
Sbjct: 322 VVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASF 381
Query: 475 FDL---YDPPPDVSCVDVDTNTISQIGDKKNVAWKILP-------KKPCKNLMNTLN--- 521
F + P DV VD+D+N + I ILP KK K + +++
Sbjct: 382 FLYKLDFKMPDDVWLVDLDSNRV--IAPTNAEVLPILPEPESLELKKHLKQALASMSLNT 439
Query: 522 ----NLH-----QQLAKLQQRPRDDGLMDLAINDYDFNSGKRLHMIDLEIQEAFLFFM-- 570
NL Q++ L RP +D + G + +D+ + A + F
Sbjct: 440 QPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGNDVDSVDVATRVAMVRFFNS 499
Query: 571 ASILKGYRSYLRPITQAPSETATDAASLFALQAFLRSRDRSHQKFYNMMTKTQ 623
A++L+G++ + R + P F +FL SR R F + +TQ
Sbjct: 500 ANVLQGFQMHTRTLRLFPRPVVA-----FQAGSFLASRPR-QTPFAEKLARTQ 546
>gi|18860873 MAP-kinase activating death domain-containing protein
isoform g [Homo sapiens]
Length = 1581
Score = 89.7 bits (221), Expect = 2e-17
Identities = 125/533 (23%), Positives = 203/533 (38%), Gaps = 123/533 (23%)
Query: 203 TNTVSYKAGLICRYPQEDYESFSLPESVPLFCLPMGATIECWPSNSKYPLPVFSTFVLTG 262
+++V+ L+ RYP ED+ F LP V FC P G + L ++FV T
Sbjct: 25 SDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEGCLSV---RQRRMSLRDDTSFVFTL 81
Query: 263 ASAEKV---YGAAIQFYEPY--------------------------SEENLTEKQRLLLG 293
+ YG + FY + SEE TE
Sbjct: 82 TDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKEGTHATCASEEGGTESSESGSS 141
Query: 294 LT--SADG--------------KSDSSKTIHTNKCICLLSHWPFFDAFRKFLTFLYRY-- 335
L SAD K+ S T +C+LSH+PFF FR+ L L R
Sbjct: 142 LQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVLSHYPFFSTFRECLYTLKRLVD 201
Query: 336 ----SISGPHV------------------LPIEKHISHFMHKV-------------PFPS 360
+ G + L +E+ S +H + P P
Sbjct: 202 CCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSALLHDLREIEAWIYRLLRSPVPV 261
Query: 361 PQRPRILVQLSPHD---NLILSQPVSSPLPLSGGKFSTLLQNLGPENAVTLLVFAVTEHK 417
+ R+ +++ P + L + P S L L+ LG + + +L + EHK
Sbjct: 262 SGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVLTCILLEHK 321
Query: 418 ILIHSLRPSVLTSVTEALVSMIFPFHWPCPYVPLCPLALA---DVLSAPCPFIVGIDSRY 474
+++ S + L+ A V+MI+P + P +PL P +A +L AP P+I+G+ + +
Sbjct: 322 VVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASF 381
Query: 475 FDL---YDPPPDVSCVDVDTNTISQIGDKKNVAWKILP-------KKPCKNLMNTLN--- 521
F + P DV VD+D+N + I ILP KK K + +++
Sbjct: 382 FLYKLDFKMPDDVWLVDLDSNRV--IAPTNAEVLPILPEPESLELKKHLKQALASMSLNT 439
Query: 522 ----NLH-----QQLAKLQQRPRDDGLMDLAINDYDFNSGKRLHMIDLEIQEAFLFFM-- 570
NL Q++ L RP +D + G + +D+ + A + F
Sbjct: 440 QPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGNDVDSVDVATRVAMVRFFNS 499
Query: 571 ASILKGYRSYLRPITQAPSETATDAASLFALQAFLRSRDRSHQKFYNMMTKTQ 623
A++L+G++ + R + P F +FL SR R F + +TQ
Sbjct: 500 ANVLQGFQMHTRTLRLFPRPVVA-----FQAGSFLASRPR-QTPFAEKLARTQ 546
>gi|209862987 MAP-kinase activating death domain-containing protein
isoform f [Homo sapiens]
Length = 1479
Score = 89.7 bits (221), Expect = 2e-17
Identities = 125/533 (23%), Positives = 203/533 (38%), Gaps = 123/533 (23%)
Query: 203 TNTVSYKAGLICRYPQEDYESFSLPESVPLFCLPMGATIECWPSNSKYPLPVFSTFVLTG 262
+++V+ L+ RYP ED+ F LP V FC P G + L ++FV T
Sbjct: 25 SDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEGCLSV---RQRRMSLRDDTSFVFTL 81
Query: 263 ASAEKV---YGAAIQFYEPY--------------------------SEENLTEKQRLLLG 293
+ YG + FY + SEE TE
Sbjct: 82 TDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKEGTHATCASEEGGTESSESGSS 141
Query: 294 LT--SADG--------------KSDSSKTIHTNKCICLLSHWPFFDAFRKFLTFLYRY-- 335
L SAD K+ S T +C+LSH+PFF FR+ L L R
Sbjct: 142 LQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVLSHYPFFSTFRECLYTLKRLVD 201
Query: 336 ----SISGPHV------------------LPIEKHISHFMHKV-------------PFPS 360
+ G + L +E+ S +H + P P
Sbjct: 202 CCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSALLHDLREIEAWIYRLLRSPVPV 261
Query: 361 PQRPRILVQLSPHD---NLILSQPVSSPLPLSGGKFSTLLQNLGPENAVTLLVFAVTEHK 417
+ R+ +++ P + L + P S L L+ LG + + +L + EHK
Sbjct: 262 SGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVLTCILLEHK 321
Query: 418 ILIHSLRPSVLTSVTEALVSMIFPFHWPCPYVPLCPLALA---DVLSAPCPFIVGIDSRY 474
+++ S + L+ A V+MI+P + P +PL P +A +L AP P+I+G+ + +
Sbjct: 322 VVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASF 381
Query: 475 FDL---YDPPPDVSCVDVDTNTISQIGDKKNVAWKILP-------KKPCKNLMNTLN--- 521
F + P DV VD+D+N + I ILP KK K + +++
Sbjct: 382 FLYKLDFKMPDDVWLVDLDSNRV--IAPTNAEVLPILPEPESLELKKHLKQALASMSLNT 439
Query: 522 ----NLH-----QQLAKLQQRPRDDGLMDLAINDYDFNSGKRLHMIDLEIQEAFLFFM-- 570
NL Q++ L RP +D + G + +D+ + A + F
Sbjct: 440 QPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGNDVDSVDVATRVAMVRFFNS 499
Query: 571 ASILKGYRSYLRPITQAPSETATDAASLFALQAFLRSRDRSHQKFYNMMTKTQ 623
A++L+G++ + R + P F +FL SR R F + +TQ
Sbjct: 500 ANVLQGFQMHTRTLRLFPRPVVA-----FQAGSFLASRPR-QTPFAEKLARTQ 546
>gi|209862983 MAP-kinase activating death domain-containing protein
isoform e [Homo sapiens]
Length = 1608
Score = 89.7 bits (221), Expect = 2e-17
Identities = 125/533 (23%), Positives = 203/533 (38%), Gaps = 123/533 (23%)
Query: 203 TNTVSYKAGLICRYPQEDYESFSLPESVPLFCLPMGATIECWPSNSKYPLPVFSTFVLTG 262
+++V+ L+ RYP ED+ F LP V FC P G + L ++FV T
Sbjct: 25 SDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEGCLSV---RQRRMSLRDDTSFVFTL 81
Query: 263 ASAEKV---YGAAIQFYEPY--------------------------SEENLTEKQRLLLG 293
+ YG + FY + SEE TE
Sbjct: 82 TDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKEGTHATCASEEGGTESSESGSS 141
Query: 294 LT--SADG--------------KSDSSKTIHTNKCICLLSHWPFFDAFRKFLTFLYRY-- 335
L SAD K+ S T +C+LSH+PFF FR+ L L R
Sbjct: 142 LQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVLSHYPFFSTFRECLYTLKRLVD 201
Query: 336 ----SISGPHV------------------LPIEKHISHFMHKV-------------PFPS 360
+ G + L +E+ S +H + P P
Sbjct: 202 CCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSALLHDLREIEAWIYRLLRSPVPV 261
Query: 361 PQRPRILVQLSPHD---NLILSQPVSSPLPLSGGKFSTLLQNLGPENAVTLLVFAVTEHK 417
+ R+ +++ P + L + P S L L+ LG + + +L + EHK
Sbjct: 262 SGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVLTCILLEHK 321
Query: 418 ILIHSLRPSVLTSVTEALVSMIFPFHWPCPYVPLCPLALA---DVLSAPCPFIVGIDSRY 474
+++ S + L+ A V+MI+P + P +PL P +A +L AP P+I+G+ + +
Sbjct: 322 VVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASF 381
Query: 475 FDL---YDPPPDVSCVDVDTNTISQIGDKKNVAWKILP-------KKPCKNLMNTLN--- 521
F + P DV VD+D+N + I ILP KK K + +++
Sbjct: 382 FLYKLDFKMPDDVWLVDLDSNRV--IAPTNAEVLPILPEPESLELKKHLKQALASMSLNT 439
Query: 522 ----NLH-----QQLAKLQQRPRDDGLMDLAINDYDFNSGKRLHMIDLEIQEAFLFFM-- 570
NL Q++ L RP +D + G + +D+ + A + F
Sbjct: 440 QPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGNDVDSVDVATRVAMVRFFNS 499
Query: 571 ASILKGYRSYLRPITQAPSETATDAASLFALQAFLRSRDRSHQKFYNMMTKTQ 623
A++L+G++ + R + P F +FL SR R F + +TQ
Sbjct: 500 ANVLQGFQMHTRTLRLFPRPVVA-----FQAGSFLASRPR-QTPFAEKLARTQ 546
>gi|209862979 MAP-kinase activating death domain-containing protein
isoform c [Homo sapiens]
Length = 1545
Score = 89.7 bits (221), Expect = 2e-17
Identities = 125/533 (23%), Positives = 203/533 (38%), Gaps = 123/533 (23%)
Query: 203 TNTVSYKAGLICRYPQEDYESFSLPESVPLFCLPMGATIECWPSNSKYPLPVFSTFVLTG 262
+++V+ L+ RYP ED+ F LP V FC P G + L ++FV T
Sbjct: 25 SDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEGCLSV---RQRRMSLRDDTSFVFTL 81
Query: 263 ASAEKV---YGAAIQFYEPY--------------------------SEENLTEKQRLLLG 293
+ YG + FY + SEE TE
Sbjct: 82 TDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKEGTHATCASEEGGTESSESGSS 141
Query: 294 LT--SADG--------------KSDSSKTIHTNKCICLLSHWPFFDAFRKFLTFLYRY-- 335
L SAD K+ S T +C+LSH+PFF FR+ L L R
Sbjct: 142 LQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVLSHYPFFSTFRECLYTLKRLVD 201
Query: 336 ----SISGPHV------------------LPIEKHISHFMHKV-------------PFPS 360
+ G + L +E+ S +H + P P
Sbjct: 202 CCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSALLHDLREIEAWIYRLLRSPVPV 261
Query: 361 PQRPRILVQLSPHD---NLILSQPVSSPLPLSGGKFSTLLQNLGPENAVTLLVFAVTEHK 417
+ R+ +++ P + L + P S L L+ LG + + +L + EHK
Sbjct: 262 SGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVLTCILLEHK 321
Query: 418 ILIHSLRPSVLTSVTEALVSMIFPFHWPCPYVPLCPLALA---DVLSAPCPFIVGIDSRY 474
+++ S + L+ A V+MI+P + P +PL P +A +L AP P+I+G+ + +
Sbjct: 322 VVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASF 381
Query: 475 FDL---YDPPPDVSCVDVDTNTISQIGDKKNVAWKILP-------KKPCKNLMNTLN--- 521
F + P DV VD+D+N + I ILP KK K + +++
Sbjct: 382 FLYKLDFKMPDDVWLVDLDSNRV--IAPTNAEVLPILPEPESLELKKHLKQALASMSLNT 439
Query: 522 ----NLH-----QQLAKLQQRPRDDGLMDLAINDYDFNSGKRLHMIDLEIQEAFLFFM-- 570
NL Q++ L RP +D + G + +D+ + A + F
Sbjct: 440 QPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGNDVDSVDVATRVAMVRFFNS 499
Query: 571 ASILKGYRSYLRPITQAPSETATDAASLFALQAFLRSRDRSHQKFYNMMTKTQ 623
A++L+G++ + R + P F +FL SR R F + +TQ
Sbjct: 500 ANVLQGFQMHTRTLRLFPRPVVA-----FQAGSFLASRPR-QTPFAEKLARTQ 546
>gi|209862975 MAP-kinase activating death domain-containing protein
isoform b [Homo sapiens]
Length = 1565
Score = 89.7 bits (221), Expect = 2e-17
Identities = 125/533 (23%), Positives = 203/533 (38%), Gaps = 123/533 (23%)
Query: 203 TNTVSYKAGLICRYPQEDYESFSLPESVPLFCLPMGATIECWPSNSKYPLPVFSTFVLTG 262
+++V+ L+ RYP ED+ F LP V FC P G + L ++FV T
Sbjct: 25 SDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEGCLSV---RQRRMSLRDDTSFVFTL 81
Query: 263 ASAEKV---YGAAIQFYEPY--------------------------SEENLTEKQRLLLG 293
+ YG + FY + SEE TE
Sbjct: 82 TDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKEGTHATCASEEGGTESSESGSS 141
Query: 294 LT--SADG--------------KSDSSKTIHTNKCICLLSHWPFFDAFRKFLTFLYRY-- 335
L SAD K+ S T +C+LSH+PFF FR+ L L R
Sbjct: 142 LQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVLSHYPFFSTFRECLYTLKRLVD 201
Query: 336 ----SISGPHV------------------LPIEKHISHFMHKV-------------PFPS 360
+ G + L +E+ S +H + P P
Sbjct: 202 CCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSALLHDLREIEAWIYRLLRSPVPV 261
Query: 361 PQRPRILVQLSPHD---NLILSQPVSSPLPLSGGKFSTLLQNLGPENAVTLLVFAVTEHK 417
+ R+ +++ P + L + P S L L+ LG + + +L + EHK
Sbjct: 262 SGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVLTCILLEHK 321
Query: 418 ILIHSLRPSVLTSVTEALVSMIFPFHWPCPYVPLCPLALA---DVLSAPCPFIVGIDSRY 474
+++ S + L+ A V+MI+P + P +PL P +A +L AP P+I+G+ + +
Sbjct: 322 VVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASF 381
Query: 475 FDL---YDPPPDVSCVDVDTNTISQIGDKKNVAWKILP-------KKPCKNLMNTLN--- 521
F + P DV VD+D+N + I ILP KK K + +++
Sbjct: 382 FLYKLDFKMPDDVWLVDLDSNRV--IAPTNAEVLPILPEPESLELKKHLKQALASMSLNT 439
Query: 522 ----NLH-----QQLAKLQQRPRDDGLMDLAINDYDFNSGKRLHMIDLEIQEAFLFFM-- 570
NL Q++ L RP +D + G + +D+ + A + F
Sbjct: 440 QPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGNDVDSVDVATRVAMVRFFNS 499
Query: 571 ASILKGYRSYLRPITQAPSETATDAASLFALQAFLRSRDRSHQKFYNMMTKTQ 623
A++L+G++ + R + P F +FL SR R F + +TQ
Sbjct: 500 ANVLQGFQMHTRTLRLFPRPVVA-----FQAGSFLASRPR-QTPFAEKLARTQ 546
>gi|209862971 MAP-kinase activating death domain-containing protein
isoform a [Homo sapiens]
Length = 1588
Score = 89.7 bits (221), Expect = 2e-17
Identities = 125/533 (23%), Positives = 203/533 (38%), Gaps = 123/533 (23%)
Query: 203 TNTVSYKAGLICRYPQEDYESFSLPESVPLFCLPMGATIECWPSNSKYPLPVFSTFVLTG 262
+++V+ L+ RYP ED+ F LP V FC P G + L ++FV T
Sbjct: 25 SDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEGCLSV---RQRRMSLRDDTSFVFTL 81
Query: 263 ASAEKV---YGAAIQFYEPY--------------------------SEENLTEKQRLLLG 293
+ YG + FY + SEE TE
Sbjct: 82 TDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKEGTHATCASEEGGTESSESGSS 141
Query: 294 LT--SADG--------------KSDSSKTIHTNKCICLLSHWPFFDAFRKFLTFLYRY-- 335
L SAD K+ S T +C+LSH+PFF FR+ L L R
Sbjct: 142 LQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVLSHYPFFSTFRECLYTLKRLVD 201
Query: 336 ----SISGPHV------------------LPIEKHISHFMHKV-------------PFPS 360
+ G + L +E+ S +H + P P
Sbjct: 202 CCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSALLHDLREIEAWIYRLLRSPVPV 261
Query: 361 PQRPRILVQLSPHD---NLILSQPVSSPLPLSGGKFSTLLQNLGPENAVTLLVFAVTEHK 417
+ R+ +++ P + L + P S L L+ LG + + +L + EHK
Sbjct: 262 SGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVLTCILLEHK 321
Query: 418 ILIHSLRPSVLTSVTEALVSMIFPFHWPCPYVPLCPLALA---DVLSAPCPFIVGIDSRY 474
+++ S + L+ A V+MI+P + P +PL P +A +L AP P+I+G+ + +
Sbjct: 322 VVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASF 381
Query: 475 FDL---YDPPPDVSCVDVDTNTISQIGDKKNVAWKILP-------KKPCKNLMNTLN--- 521
F + P DV VD+D+N + I ILP KK K + +++
Sbjct: 382 FLYKLDFKMPDDVWLVDLDSNRV--IAPTNAEVLPILPEPESLELKKHLKQALASMSLNT 439
Query: 522 ----NLH-----QQLAKLQQRPRDDGLMDLAINDYDFNSGKRLHMIDLEIQEAFLFFM-- 570
NL Q++ L RP +D + G + +D+ + A + F
Sbjct: 440 QPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGNDVDSVDVATRVAMVRFFNS 499
Query: 571 ASILKGYRSYLRPITQAPSETATDAASLFALQAFLRSRDRSHQKFYNMMTKTQ 623
A++L+G++ + R + P F +FL SR R F + +TQ
Sbjct: 500 ANVLQGFQMHTRTLRLFPRPVVA-----FQAGSFLASRPR-QTPFAEKLARTQ 546
>gi|209571517 MAP-kinase activating death domain-containing protein
isoform h [Homo sapiens]
Length = 1587
Score = 89.7 bits (221), Expect = 2e-17
Identities = 125/533 (23%), Positives = 203/533 (38%), Gaps = 123/533 (23%)
Query: 203 TNTVSYKAGLICRYPQEDYESFSLPESVPLFCLPMGATIECWPSNSKYPLPVFSTFVLTG 262
+++V+ L+ RYP ED+ F LP V FC P G + L ++FV T
Sbjct: 25 SDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEGCLSV---RQRRMSLRDDTSFVFTL 81
Query: 263 ASAEKV---YGAAIQFYEPY--------------------------SEENLTEKQRLLLG 293
+ YG + FY + SEE TE
Sbjct: 82 TDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKEGTHATCASEEGGTESSESGSS 141
Query: 294 LT--SADG--------------KSDSSKTIHTNKCICLLSHWPFFDAFRKFLTFLYRY-- 335
L SAD K+ S T +C+LSH+PFF FR+ L L R
Sbjct: 142 LQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVLSHYPFFSTFRECLYTLKRLVD 201
Query: 336 ----SISGPHV------------------LPIEKHISHFMHKV-------------PFPS 360
+ G + L +E+ S +H + P P
Sbjct: 202 CCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSALLHDLREIEAWIYRLLRSPVPV 261
Query: 361 PQRPRILVQLSPHD---NLILSQPVSSPLPLSGGKFSTLLQNLGPENAVTLLVFAVTEHK 417
+ R+ +++ P + L + P S L L+ LG + + +L + EHK
Sbjct: 262 SGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVLTCILLEHK 321
Query: 418 ILIHSLRPSVLTSVTEALVSMIFPFHWPCPYVPLCPLALA---DVLSAPCPFIVGIDSRY 474
+++ S + L+ A V+MI+P + P +PL P +A +L AP P+I+G+ + +
Sbjct: 322 VVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASF 381
Query: 475 FDL---YDPPPDVSCVDVDTNTISQIGDKKNVAWKILP-------KKPCKNLMNTLN--- 521
F + P DV VD+D+N + I ILP KK K + +++
Sbjct: 382 FLYKLDFKMPDDVWLVDLDSNRV--IAPTNAEVLPILPEPESLELKKHLKQALASMSLNT 439
Query: 522 ----NLH-----QQLAKLQQRPRDDGLMDLAINDYDFNSGKRLHMIDLEIQEAFLFFM-- 570
NL Q++ L RP +D + G + +D+ + A + F
Sbjct: 440 QPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGNDVDSVDVATRVAMVRFFNS 499
Query: 571 ASILKGYRSYLRPITQAPSETATDAASLFALQAFLRSRDRSHQKFYNMMTKTQ 623
A++L+G++ + R + P F +FL SR R F + +TQ
Sbjct: 500 ANVLQGFQMHTRTLRLFPRPVVA-----FQAGSFLASRPR-QTPFAEKLARTQ 546
>gi|154813195 DENN/MADD domain containing 2A [Homo sapiens]
Length = 1009
Score = 85.5 bits (210), Expect = 4e-16
Identities = 101/412 (24%), Positives = 181/412 (43%), Gaps = 67/412 (16%)
Query: 228 ESVPLFCLPMGATIECWPSNSKYPLPVFSTFVLTGASAEKVYGAAIQFYEPYSEENLTEK 287
+++P FC P + W ++ FS FVLTG + +G
Sbjct: 609 KAIPQFCFP---DAKDWVPVQQFTSETFS-FVLTGEDGSRRFGYC--------------- 649
Query: 288 QRLLLGLTSADGKSDSSKTIHTNKCICLLSHWPFFDAFRKFLTFLY-RYSISGPHVLPIE 346
+RLL G GK ++ C++S F F + L + R IS V P+
Sbjct: 650 RRLLPG-----GKGKRLPEVY-----CIVSRLGCFSLFSRILDEVEKRRGISPALVQPLM 699
Query: 347 KHISHFMHKVPFPSPQRPRILVQLSPHDN---LILSQPVSSPLPLSGGKFSTLLQNLGPE 403
+ + + PFP+ + ++ P + L +P+ S L F +L +L
Sbjct: 700 RSVM----EAPFPALGKTILVKNFLPGSGTEVIELCRPLDSRL--EHVDFESLFSSLSVR 753
Query: 404 NAVTLLVFAVTEHKILIHSLRPSVLTSVTEALVSMIFPFHWPCPYVPLCPLALADVLSAP 463
+ V + + E +++ + + S+L+ A+V++I+PF W Y+P+ P A+ D++ +P
Sbjct: 754 HLVCVFASLLLERRVIFIADKLSILSKCCHAMVALIYPFAWQHTYIPVLPPAMVDIVCSP 813
Query: 464 CPFIVGIDSRYFDLYD--PPPDVSCVD-VDTNTISQIGDKKNVAWKILPKKPCKNLMNTL 520
PF++G+ S L P +V VD V++ + Q+ D+ + ILP+K L L
Sbjct: 814 TPFLIGLLSSSLPLLRELPLEEVLVVDLVNSRFLRQMDDEDS----ILPRK----LQVAL 865
Query: 521 NNLHQQLAKLQQRPRDDGLMDLAINDYDFNSGKRLHMIDLEIQEAFLFFMASILKGYRSY 580
++ +Q +L +D+G + D G ++ + EAF+ F I+ Y +
Sbjct: 866 EHILEQRNELACE-QDEGPL-------DGRHGPESSPLNEVVSEAFVRFFVEIVGHYSLF 917
Query: 581 LRPITQAPSETATDAASLFALQAFLRS-RDRSHQKFYNMMTKTQMFIRFIEE 631
L T E T +AF ++ +S + F + +TQMF FI+E
Sbjct: 918 L---TSGEREERT-----LQREAFRKAVSSKSLRHFLEVFMETQMFRGFIQE 961
>gi|218563726 DENN/MADD domain containing 1B isoform 1 [Homo
sapiens]
Length = 755
Score = 83.2 bits (204), Expect = 2e-15
Identities = 100/425 (23%), Positives = 158/425 (37%), Gaps = 95/425 (22%)
Query: 212 LICRYPQEDYESFSLPESVPLFCLPMGATIECWPSNSKYPLPVFSTFVLTGASAEKVYGA 271
++ ++P ED+ + +SVP FC P S+ + TFVLT +++ +G
Sbjct: 31 VLWKFP-EDFGDQEILQSVPKFCFPFDVE-----RVSQNQVGQHFTFVLTDIESKQRFGF 84
Query: 272 AIQFYEPYSEENLTEKQRLLLGLTSADGKSDSSKTIHTNKCICLLSHWPFFDAFRKFLTF 331
RL G T C+C+LS+ P+F+ + K L
Sbjct: 85 C----------------RLTSGGTI---------------CLCILSYLPWFEVYYKLLNT 113
Query: 332 LYRYSISGPHVLPIEKHISHFMHKV---PFPSPQRPRILVQLSPHDNLILSQPVSSPLPL 388
L Y +E ++ + + P P P V LS H I P
Sbjct: 114 LADYLAK-----ELENDLNETLRSLYNHPVPKANTP---VNLSVHSYFIAPDVTGLPTIP 165
Query: 389 SGGKFSTLLQNLGPENAVTLLVFAVTEHKILIHSLRPSVLTSVTEALVSMIFPFHWPCPY 448
+ + N + L + E +I+I S + S LT+ ++++P +W Y
Sbjct: 166 ESRNLTEYFVAVDVNNMLQLYASMLHERRIVIISSKLSTLTACIHGSAALLYPMYWQHIY 225
Query: 449 VPLCPLALADVLSAPCPFIVGIDSRYFDLYDPP--PDVSCVDVDTNTI-SQIGDKKNVAW 505
+P+ P L D AP P+++GI S + DV ++VDTNT+ S D N
Sbjct: 226 IPVLPPHLLDYCCAPMPYLIGIHSSLIERVKNKSLEDVVMLNVDTNTLESPFSDLNN--- 282
Query: 506 KILPKKPCKNLMNTLNNLHQQLAKLQQRPRDDGLMDLAINDYDFNSGKRLHMIDLEIQEA 565
LP L N L K Q DG + A
Sbjct: 283 --LPSDVVSALKNKL--------KKQSTATGDG-----------------------VARA 309
Query: 566 FLFFMASILKGYRSYLRPITQAPSETATDAASLFALQAFLRSRDRSHQKFYNMMTKTQMF 625
FL A++ YR LR P E T F ++F++ R ++F Q+F
Sbjct: 310 FLRAQAALFGSYRDALR---YKPGEPIT-----FCEESFVKHRSSVMKQFLETAINLQLF 361
Query: 626 IRFIE 630
+FI+
Sbjct: 362 KQFID 366
>gi|47132529 suppression of tumorigenicity 5 isoform 1 [Homo sapiens]
Length = 1137
Score = 79.7 bits (195), Expect = 2e-14
Identities = 100/434 (23%), Positives = 180/434 (41%), Gaps = 71/434 (16%)
Query: 206 VSYKAGLICRYPQEDYESFSLPESVPLFCLPMGATIECWPSNSKYPLPVFSTFVLTGASA 265
VSY+ + R ++ E+ +++P FC P + W S+Y FS F+LTG
Sbjct: 718 VSYQFPKLDRPTKQMREAEERLKAIPQFCFP---DAKDWLPVSEYSSETFS-FMLTGEDG 773
Query: 266 EKVYGAAIQFYEPYSEENLTEKQRLLLGLTSADGKSDSSKTIHTNKCICLLSHWPFFDAF 325
+ +G +RLL S K + C++S F F
Sbjct: 774 SRRFGYC---------------RRLL----------PSGKGPRLPEVYCVISRLGCFGLF 808
Query: 326 RKFLTFLYRY-SISGPHVLPIEKHISHFMHKVPFPSPQRPRILVQLSP---HDNLILSQP 381
K L + R IS V P + + + PFP+P + + P ++ L L +P
Sbjct: 809 SKVLDEVERRRGISAALVYPFMRSLM----ESPFPAPGKTIKVKTFLPGAGNEVLELRRP 864
Query: 382 VSSPLPLSGGKFSTLLQNLGPENAVTLLVFAVTEHKILIHSLRPSVLTSVTEALVSMIFP 441
+ S L F L L + + + E +++ + + S L+S + A+V++++P
Sbjct: 865 MDSRL--EHVDFECLFTCLSVRQLIRIFASLLLERRVIFVADKLSTLSSCSHAVVALLYP 922
Query: 442 FHWPCPYVPLCPLALADVLSAPCPFIVGIDSRYFDLYDPPPDVSCVDVDTNT---ISQIG 498
F W ++P+ P ++ D++ P PF+VG+ S P + V+ + I Q+
Sbjct: 923 FSWQHTFIPVLPASMIDIVCCPTPFLVGLLSSSLPKLKELPVEEALMVNLGSDRFIRQMD 982
Query: 499 DKKNVAWKILPKKPCKNLMNTLNNLHQQLAKLQQRPRDDGLMDLAINDYDFNSGKRLHMI 558
D+ +LP+K L L + +R +L D D +S + +
Sbjct: 983 DEDT----LLPRK-----------LQAALEQALERKN-----ELISQDSDSDSDDECNTL 1022
Query: 559 DLEIQEAFLFFMASILKGYRSYLRPITQAPSETATDAASLFALQAFLRS-RDRSHQKFYN 617
+ + E F+ F + Y +L SE A F +AF +S +S ++F
Sbjct: 1023 NGLVSEVFIRFFVETVGHYSLFL-----TQSEKGERA---FQREAFRKSVASKSIRRFLE 1074
Query: 618 MMTKTQMFIRFIEE 631
+ ++QMF FI++
Sbjct: 1075 VFMESQMFAGFIQD 1088
>gi|47132532 suppression of tumorigenicity 5 isoform 1 [Homo sapiens]
Length = 1137
Score = 79.7 bits (195), Expect = 2e-14
Identities = 100/434 (23%), Positives = 180/434 (41%), Gaps = 71/434 (16%)
Query: 206 VSYKAGLICRYPQEDYESFSLPESVPLFCLPMGATIECWPSNSKYPLPVFSTFVLTGASA 265
VSY+ + R ++ E+ +++P FC P + W S+Y FS F+LTG
Sbjct: 718 VSYQFPKLDRPTKQMREAEERLKAIPQFCFP---DAKDWLPVSEYSSETFS-FMLTGEDG 773
Query: 266 EKVYGAAIQFYEPYSEENLTEKQRLLLGLTSADGKSDSSKTIHTNKCICLLSHWPFFDAF 325
+ +G +RLL S K + C++S F F
Sbjct: 774 SRRFGYC---------------RRLL----------PSGKGPRLPEVYCVISRLGCFGLF 808
Query: 326 RKFLTFLYRY-SISGPHVLPIEKHISHFMHKVPFPSPQRPRILVQLSP---HDNLILSQP 381
K L + R IS V P + + + PFP+P + + P ++ L L +P
Sbjct: 809 SKVLDEVERRRGISAALVYPFMRSLM----ESPFPAPGKTIKVKTFLPGAGNEVLELRRP 864
Query: 382 VSSPLPLSGGKFSTLLQNLGPENAVTLLVFAVTEHKILIHSLRPSVLTSVTEALVSMIFP 441
+ S L F L L + + + E +++ + + S L+S + A+V++++P
Sbjct: 865 MDSRL--EHVDFECLFTCLSVRQLIRIFASLLLERRVIFVADKLSTLSSCSHAVVALLYP 922
Query: 442 FHWPCPYVPLCPLALADVLSAPCPFIVGIDSRYFDLYDPPPDVSCVDVDTNT---ISQIG 498
F W ++P+ P ++ D++ P PF+VG+ S P + V+ + I Q+
Sbjct: 923 FSWQHTFIPVLPASMIDIVCCPTPFLVGLLSSSLPKLKELPVEEALMVNLGSDRFIRQMD 982
Query: 499 DKKNVAWKILPKKPCKNLMNTLNNLHQQLAKLQQRPRDDGLMDLAINDYDFNSGKRLHMI 558
D+ +LP+K L L + +R +L D D +S + +
Sbjct: 983 DEDT----LLPRK-----------LQAALEQALERKN-----ELISQDSDSDSDDECNTL 1022
Query: 559 DLEIQEAFLFFMASILKGYRSYLRPITQAPSETATDAASLFALQAFLRS-RDRSHQKFYN 617
+ + E F+ F + Y +L SE A F +AF +S +S ++F
Sbjct: 1023 NGLVSEVFIRFFVETVGHYSLFL-----TQSEKGERA---FQREAFRKSVASKSIRRFLE 1074
Query: 618 MMTKTQMFIRFIEE 631
+ ++QMF FI++
Sbjct: 1075 VFMESQMFAGFIQD 1088
>gi|21264614 suppression of tumorigenicity 5 isoform 2 [Homo
sapiens]
Length = 717
Score = 79.7 bits (195), Expect = 2e-14
Identities = 100/434 (23%), Positives = 180/434 (41%), Gaps = 71/434 (16%)
Query: 206 VSYKAGLICRYPQEDYESFSLPESVPLFCLPMGATIECWPSNSKYPLPVFSTFVLTGASA 265
VSY+ + R ++ E+ +++P FC P + W S+Y FS F+LTG
Sbjct: 298 VSYQFPKLDRPTKQMREAEERLKAIPQFCFP---DAKDWLPVSEYSSETFS-FMLTGEDG 353
Query: 266 EKVYGAAIQFYEPYSEENLTEKQRLLLGLTSADGKSDSSKTIHTNKCICLLSHWPFFDAF 325
+ +G +RLL S K + C++S F F
Sbjct: 354 SRRFGYC---------------RRLL----------PSGKGPRLPEVYCVISRLGCFGLF 388
Query: 326 RKFLTFLYRY-SISGPHVLPIEKHISHFMHKVPFPSPQRPRILVQLSP---HDNLILSQP 381
K L + R IS V P + + + PFP+P + + P ++ L L +P
Sbjct: 389 SKVLDEVERRRGISAALVYPFMRSLM----ESPFPAPGKTIKVKTFLPGAGNEVLELRRP 444
Query: 382 VSSPLPLSGGKFSTLLQNLGPENAVTLLVFAVTEHKILIHSLRPSVLTSVTEALVSMIFP 441
+ S L F L L + + + E +++ + + S L+S + A+V++++P
Sbjct: 445 MDSRL--EHVDFECLFTCLSVRQLIRIFASLLLERRVIFVADKLSTLSSCSHAVVALLYP 502
Query: 442 FHWPCPYVPLCPLALADVLSAPCPFIVGIDSRYFDLYDPPPDVSCVDVDTNT---ISQIG 498
F W ++P+ P ++ D++ P PF+VG+ S P + V+ + I Q+
Sbjct: 503 FSWQHTFIPVLPASMIDIVCCPTPFLVGLLSSSLPKLKELPVEEALMVNLGSDRFIRQMD 562
Query: 499 DKKNVAWKILPKKPCKNLMNTLNNLHQQLAKLQQRPRDDGLMDLAINDYDFNSGKRLHMI 558
D+ +LP+K L L + +R +L D D +S + +
Sbjct: 563 DEDT----LLPRK-----------LQAALEQALERKN-----ELISQDSDSDSDDECNTL 602
Query: 559 DLEIQEAFLFFMASILKGYRSYLRPITQAPSETATDAASLFALQAFLRS-RDRSHQKFYN 617
+ + E F+ F + Y +L SE A F +AF +S +S ++F
Sbjct: 603 NGLVSEVFIRFFVETVGHYSLFL-----TQSEKGERA---FQREAFRKSVASKSIRRFLE 654
Query: 618 MMTKTQMFIRFIEE 631
+ ++QMF FI++
Sbjct: 655 VFMESQMFAGFIQD 668
>gi|121949817 DENN/MADD domain containing 2C [Homo sapiens]
Length = 871
Score = 79.3 bits (194), Expect = 3e-14
Identities = 103/445 (23%), Positives = 184/445 (41%), Gaps = 81/445 (18%)
Query: 202 KTNTVSYKAGLICRYPQEDYESFSLPES-------VPLFCLPMGATIECWPSNSKYPLPV 254
K + +SY +I ++P +D + + +P FC P W S+
Sbjct: 445 KPSGISYIPQVIQQFPGKDDHGYKQSKDMEERLKVIPKFCFPDSKD---WMPTSELKSET 501
Query: 255 FSTFVLTGASAEKVYGAAIQFYEPYSEENLTEKQRLLLGLTSADGKSDSSKTIHTNKCIC 314
FS FVLTG + +G K+ L +G K + C
Sbjct: 502 FS-FVLTGEDGSRWFGYC--------------KKLLPVG-----------KGKRLPEVYC 535
Query: 315 LLSHWPFFDAFRKFLTFLY-RYSISGPHVLPIEKHISHFMHKVPFPSPQRPRILVQLSP- 372
++S F+ F K L + R +S V P + + + PFP+P R + P
Sbjct: 536 MVSRLGCFNLFSKILDEVEKRREMSPALVYPFMRSVM----EAPFPAPGRTITVKSYLPG 591
Query: 373 --HDNLILSQPVSSPLPLSGGKFSTLLQNLGPENAVTLLVFAVTEHKILIHSLRPSVLTS 430
+++ L +P+ S L F L + L + + + + E +++ + S L+
Sbjct: 592 AGDESIELCRPLDSRL--EHVDFKCLFKCLSVCHLIRVCASLLLERRVIFVANSLSTLSK 649
Query: 431 VTEALVSMIFPFHWPCPYVPLCPLALADVLSAPCPFIVGIDSRYF-DLYD-PPPDVSCVD 488
A+V+ ++PF W Y+P+ P ++ D++ +P PF++GI S L D P +V VD
Sbjct: 650 CGHAVVATLYPFTWQHTYIPVLPASMIDIVCSPTPFLIGILSCSLPQLQDLPIEEVLIVD 709
Query: 489 VDTNT-ISQIGDKKNVAWKILPKKPCKNLMNTLNNLHQQLAKLQQRPRDDGLMDLAINDY 547
+ + + ++ D+ +ILP K LM L ++ L + Q +D L L
Sbjct: 710 LCADKFLQEVSDED----EILPPKLQAALMQILEERNEILTQEQNFSQDVTLNSL----- 760
Query: 548 DFNSGKRLHMIDLEIQEAFLFFMASILKGYRSYLRPITQAPSETATDAASLFALQAFLRS 607
+ EAF+ F ++ G+ S +T+ +F + F +S
Sbjct: 761 --------------VSEAFVRFFVELV-GHYSLNMTVTER-------GERVFQREPFRKS 798
Query: 608 R-DRSHQKFYNMMTKTQMFIRFIEE 631
RS + F ++ +TQMF FI++
Sbjct: 799 HTSRSVRHFLDLFMETQMFAGFIQD 823
>gi|55749789 DENN/MADD domain containing 1A isoform 2 [Homo sapiens]
Length = 559
Score = 78.2 bits (191), Expect = 7e-14
Identities = 89/377 (23%), Positives = 146/377 (38%), Gaps = 59/377 (15%)
Query: 264 SAEKVYGAAIQFYEPYSEENLTEKQ---RLLLGLTSADGKSDSS---KTIHTNKCICLLS 317
S ++V +F P+ ++LT Q LT D K + C C+LS
Sbjct: 42 SDQEVLQTLTKFCFPFYVDSLTVSQVGQNFTFVLTDIDSKQRFGFCRLSSGAKSCFCILS 101
Query: 318 HWPFFDAFRKFLTFLYRYSISGPHVLPIEKHISHFMHKVPFPSPQRPRILVQLSPHDNLI 377
+ P+F+ F K L L Y+ E + +HK+P P P + V LS H
Sbjct: 102 YLPWFEVFYKLLNILADYTTKRQENQWNE--LLETLHKLPIPDPG---VSVHLSVHSYFT 156
Query: 378 LSQPVSSPLPLSGGKFSTLLQNLGPENAVTLLVFAVTEHKILIHSLRPSVLTSVTEALVS 437
+ P + + N + L + E +ILI + S LT+ +
Sbjct: 157 VPDTRELPSIPENRNLTEYFVAVDVNNMLHLYASMLYERRILIICSKLSTLTACIHGSAA 216
Query: 438 MIFPFHWPCPYVPLCPLALADVLSAPCPFIVGIDSRYFDLYD--PPPDVSCVDVDTNTIS 495
M++P +W Y+P+ P L D AP P+++GI + DV ++VDTNT+
Sbjct: 217 MLYPMYWQHVYIPVLPPHLLDYCCAPMPYLIGIHLSLMEKVRNMALDDVVILNVDTNTLE 276
Query: 496 QIGDKKNVAWKILPKKPCKNLMN-TLNNLHQQLAKLQQRPRDDGLMDLAINDYDFNSGKR 554
P ++L N +++L +L K+ D
Sbjct: 277 ------------TPFDDLQSLPNDVISSLKNRLKKVSTTTGDG----------------- 307
Query: 555 LHMIDLEIQEAFLFFMASILKGYRSYLRPITQAPSETATDAASLFALQAFL-RSRDRSHQ 613
+ AFL A+ YR+ L+ P E T F +AF+ R + +
Sbjct: 308 -------VARAFLKAQAAFFGSYRNALK---IEPEEPIT-----FCEEAFVSHYRSGAMR 352
Query: 614 KFYNMMTKTQMFIRFIE 630
+F T+ Q+F +FI+
Sbjct: 353 QFLQNATQLQLFKQFID 369
>gi|55749779 DENN/MADD domain containing 1A isoform 1 [Homo sapiens]
Length = 1009
Score = 78.2 bits (191), Expect = 7e-14
Identities = 89/377 (23%), Positives = 146/377 (38%), Gaps = 59/377 (15%)
Query: 264 SAEKVYGAAIQFYEPYSEENLTEKQ---RLLLGLTSADGKSDSS---KTIHTNKCICLLS 317
S ++V +F P+ ++LT Q LT D K + C C+LS
Sbjct: 42 SDQEVLQTLTKFCFPFYVDSLTVSQVGQNFTFVLTDIDSKQRFGFCRLSSGAKSCFCILS 101
Query: 318 HWPFFDAFRKFLTFLYRYSISGPHVLPIEKHISHFMHKVPFPSPQRPRILVQLSPHDNLI 377
+ P+F+ F K L L Y+ E + +HK+P P P + V LS H
Sbjct: 102 YLPWFEVFYKLLNILADYTTKRQENQWNE--LLETLHKLPIPDPG---VSVHLSVHSYFT 156
Query: 378 LSQPVSSPLPLSGGKFSTLLQNLGPENAVTLLVFAVTEHKILIHSLRPSVLTSVTEALVS 437
+ P + + N + L + E +ILI + S LT+ +
Sbjct: 157 VPDTRELPSIPENRNLTEYFVAVDVNNMLHLYASMLYERRILIICSKLSTLTACIHGSAA 216
Query: 438 MIFPFHWPCPYVPLCPLALADVLSAPCPFIVGIDSRYFDLYD--PPPDVSCVDVDTNTIS 495
M++P +W Y+P+ P L D AP P+++GI + DV ++VDTNT+
Sbjct: 217 MLYPMYWQHVYIPVLPPHLLDYCCAPMPYLIGIHLSLMEKVRNMALDDVVILNVDTNTLE 276
Query: 496 QIGDKKNVAWKILPKKPCKNLMN-TLNNLHQQLAKLQQRPRDDGLMDLAINDYDFNSGKR 554
P ++L N +++L +L K+ D
Sbjct: 277 ------------TPFDDLQSLPNDVISSLKNRLKKVSTTTGDG----------------- 307
Query: 555 LHMIDLEIQEAFLFFMASILKGYRSYLRPITQAPSETATDAASLFALQAFL-RSRDRSHQ 613
+ AFL A+ YR+ L+ P E T F +AF+ R + +
Sbjct: 308 -------VARAFLKAQAAFFGSYRNALK---IEPEEPIT-----FCEEAFVSHYRSGAMR 352
Query: 614 KFYNMMTKTQMFIRFIE 630
+F T+ Q+F +FI+
Sbjct: 353 QFLQNATQLQLFKQFID 369
>gi|50345870 DENN/MADD domain containing 3 [Homo sapiens]
Length = 1198
Score = 76.3 bits (186), Expect = 3e-13
Identities = 84/415 (20%), Positives = 160/415 (38%), Gaps = 53/415 (12%)
Query: 229 SVPLFCLPMGATIECWPSNSKYPLPVFSTFVLTGASAEKVYGAAIQFYEPYSEENLTEKQ 288
++P C P G + P VLT + YG Q+Y P +E
Sbjct: 41 TLPQLCFPGGVCVATEPKED-----CVHFLVLTDVCGNRTYGVVAQYYRPLHDE------ 89
Query: 289 RLLLGLTSADGKSDSS-KTIHTNKCICLLSHWPFFDAFRKFLTFLYRYSISGPHVLPIEK 347
+GK+ +C++S +P++++ + L+ L + ++
Sbjct: 90 -----YCFYNGKTHRECPGCFVPFAVCVVSRFPYYNSLKDCLSCLLAL-LKPCKDFEVDS 143
Query: 348 HISHFMHK---VPFPSPQRPRILVQLSPHDNLILSQPVSSPLPLSGGKFSTLLQNLGPEN 404
HI F K +P P P P LV ++L P+ L PE
Sbjct: 144 HIKDFAAKLSLIPSPPPG-PLHLVFNMKSLQIVLPARADPESPILDLDLHLPLLCFRPEK 202
Query: 405 AVTLLVFAVTEHKILIHSLRPSVLTSVTEALVSMIFPFHWPCPYVPLCPLALADVLSAPC 464
+ +L +TE +I+ S ++LT VTE ++ ++P W P+VP+ + D + AP
Sbjct: 203 VLQILTCILTEQRIVFFSSDWALLTLVTECFMAYLYPLQWQHPFVPILSDQMLDFVMAPT 262
Query: 465 PFIVGIDSRYFDLYDPPPD-VSCVDVDTNTIS-QIGDKKNVAWKILPKKPCKNLMNTLNN 522
F++G +F+ D + +++D +I+ NV +P + + + +
Sbjct: 263 SFLMGCHLDHFEEVSKEADGLVLINIDHGSITYSKSTDDNVDIPDVPLLAAQTFIQRVQS 322
Query: 523 --LHQQLAKLQQRPRDDGLMDLAINDYDFNSGKR-----LHMIDLEIQEAFLFFMASILK 575
LH +L ++ D G+ ++ +IQ+ L + SI +
Sbjct: 323 LQLHHELHAAH-----------LLSSTDLKEGRAHRRSWQQKLNCQIQQTTLQLLVSIFR 371
Query: 576 GYRSYLRPITQAPSETATDAASLFALQAFLRSRDRSHQKFYNMMTKTQMFIRFIE 630
+++L +F + FL++R +FY + T MF F++
Sbjct: 372 DVKNHL-----------NYEHRVFNSEEFLKTRAPGDHQFYKQVLDTYMFHSFLK 415
>gi|188219541 DENN/MADD domain containing 1B isoform 2 [Homo
sapiens]
Length = 426
Score = 75.5 bits (184), Expect = 5e-13
Identities = 101/437 (23%), Positives = 156/437 (35%), Gaps = 99/437 (22%)
Query: 212 LICRYPQEDYESFSLPESVPLFCLPMGATIECWPSNSKYPLPVFSTFVLTGASAEKVYGA 271
++ ++P ED+ + +SVP FC P S+ + TFVLT +++ +G
Sbjct: 31 VLWKFP-EDFGDQEILQSVPKFCFPFDVE-----RVSQNQVGQHFTFVLTDIESKQRFGF 84
Query: 272 AIQFYEPYSEENLTEKQRLLLGLTSADGKSDSSKTIHTNKCICLLSHWPFFDAFRKFLTF 331
RL G T C+C+LS+ P+F+ + K L
Sbjct: 85 C----------------RLTSGGTI---------------CLCILSYLPWFEVYYKLLNT 113
Query: 332 LYRYSISGPHVLPIEKHISHFMHKVP---------------FPSPQRPRILVQLSPHDNL 376
L Y E S + H VP Q + L PH
Sbjct: 114 LADYLAKELENDLNETLRSLYNHPVPKANTPVNLSVNQEIFIACEQVLKDQPALVPHSYF 173
Query: 377 ILSQPVSSPLPLSGGKFSTLLQNLGPENAVTLLVFAVTEHKILIHSLRPSVLTSVTEALV 436
I P + + N + L + E +I+I S + S LT+
Sbjct: 174 IAPDVTGLPTIPESRNLTEYFVAVDVNNMLQLYASMLHERRIVIISSKLSTLTACIHGSA 233
Query: 437 SMIFPFHWPCPYVPLCPLALADVLSAPCPFIVGIDSRYFDLYDPP--PDVSCVDVDTNTI 494
++++P +W Y+P+ P L D AP P+++GI S + DV ++VDTNT+
Sbjct: 234 ALLYPMYWQHIYIPVLPPHLLDYCCAPMPYLIGIHSSLIERVKNKSLEDVVMLNVDTNTL 293
Query: 495 -SQIGDKKNVAWKILPKKPCKNLMNTLNNLHQQLAKLQQRPRDDGLMDLAINDYDFNSGK 553
S D N LP L N L K Q DG
Sbjct: 294 ESPFSDLNN-----LPSDVVSALKNKL--------KKQSTATGDG--------------- 325
Query: 554 RLHMIDLEIQEAFLFFMASILKGYRSYLRPITQAPSETATDAASLFALQAFLRSRDRSHQ 613
+ AFL A++ YR LR P E T F ++F++ R +
Sbjct: 326 --------VARAFLRAQAALFGSYRDALR---YKPGEPIT-----FCEESFVKHRSSVMK 369
Query: 614 KFYNMMTKTQMFIRFIE 630
+F Q+F +FI+
Sbjct: 370 QFLETAINLQLFKQFID 386
>gi|113205087 DENN/MADD domain containing 1C [Homo sapiens]
Length = 801
Score = 63.5 bits (153), Expect = 2e-09
Identities = 50/210 (23%), Positives = 89/210 (42%), Gaps = 29/210 (13%)
Query: 309 TNKCICLLSHWPFFDAFRKFLTFLYRYSISGPHVLPIEKHISHFMHKVPFPSPQRPRILV 368
T C+C+LSH P+F+ F K L + ++ V E+ + + + S P+ V
Sbjct: 91 TQSCLCILSHLPWFEVFYKLLNTVGDL-LAQDQVTEAEELLQNLFQQ----SLSGPQASV 145
Query: 369 QLSPHDNLILSQPVSSPLPLSG-------------GKFSTLLQN---------LGPENAV 406
L + +S P P G G+ ++ +N + EN V
Sbjct: 146 GLELGSGVTVSSGQGIPPPTRGNSKPLSCFVAPDSGRLPSIPENRNLTELVVAVTDENIV 205
Query: 407 TLLVFAVTEHKILIHSLRPSVLTSVTEALVSMIFPFHWPCPYVPLCPLALADVLSAPCPF 466
L + E ++L+ + + S LTS A ++++P W +P P L D AP P+
Sbjct: 206 GLFAALLAERRVLLTASKLSTLTSCVHASCALLYPMRWEHVLIPTLPPHLLDYCCAPMPY 265
Query: 467 IVGIDSRYFDLYDPP--PDVSCVDVDTNTI 494
++G+ + + DV ++VD NT+
Sbjct: 266 LIGVHASLAERVREKALEDVVVLNVDANTL 295
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.132 0.393
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 74,295,153
Number of Sequences: 37866
Number of extensions: 3564999
Number of successful extensions: 16592
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 46
Number of HSP's successfully gapped in prelim test: 119
Number of HSP's that attempted gapping in prelim test: 15867
Number of HSP's gapped (non-prelim): 647
length of query: 1863
length of database: 18,247,518
effective HSP length: 117
effective length of query: 1746
effective length of database: 13,817,196
effective search space: 24124824216
effective search space used: 24124824216
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.