Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 22095367
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|22095367 centrosomal protein 63 isoform a [Homo sapiens]
(703 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|22095367 centrosomal protein 63 isoform a [Homo sapiens] 1362 0.0
gi|109255239 centrosomal protein 63 isoform b [Homo sapiens] 940 0.0
gi|109255226 centrosomal protein 63 isoform c [Homo sapiens] 828 0.0
gi|109255236 centrosomal protein 63 isoform d [Homo sapiens] 828 0.0
gi|116812628 coiled-coil domain containing 67 [Homo sapiens] 228 2e-59
gi|87298937 centrosomal protein 110kDa [Homo sapiens] 106 8e-23
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa... 102 2e-21
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 102 2e-21
gi|109659847 filamin A interacting protein 1-like isoform 3 [Hom... 100 8e-21
gi|109659845 filamin A interacting protein 1-like isoform 1 [Hom... 100 8e-21
gi|21735548 centrosomal protein 2 [Homo sapiens] 99 1e-20
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 98 2e-20
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 98 3e-20
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 98 3e-20
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 98 3e-20
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 98 3e-20
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H... 97 4e-20
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens] 97 5e-20
gi|38044112 restin isoform b [Homo sapiens] 96 9e-20
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 96 1e-19
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 95 2e-19
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 95 3e-19
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo... 94 4e-19
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo... 94 4e-19
gi|4506751 restin isoform a [Homo sapiens] 93 1e-18
gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens] 93 1e-18
gi|31982906 cingulin-like 1 [Homo sapiens] 92 2e-18
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [... 91 4e-18
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ... 91 4e-18
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo... 91 5e-18
>gi|22095367 centrosomal protein 63 isoform a [Homo sapiens]
Length = 703
Score = 1362 bits (3526), Expect = 0.0
Identities = 703/703 (100%), Positives = 703/703 (100%)
Query: 1 MEALLEGIQNRGHGGGFLTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQE 60
MEALLEGIQNRGHGGGFLTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQE
Sbjct: 1 MEALLEGIQNRGHGGGFLTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQE 60
Query: 61 LKSLRSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKK 120
LKSLRSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKK
Sbjct: 61 LKSLRSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKK 120
Query: 121 QMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQ 180
QMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQ
Sbjct: 121 QMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQ 180
Query: 181 SEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGT 240
SEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGT
Sbjct: 181 SEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGT 240
Query: 241 SMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKAT 300
SMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKAT
Sbjct: 241 SMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKAT 300
Query: 301 NTQHAVEAIRPREESLAEKKYTSQGQGDLDSVLSQLNFTHTSEDLLQAEVTCLEGSLESV 360
NTQHAVEAIRPREESLAEKKYTSQGQGDLDSVLSQLNFTHTSEDLLQAEVTCLEGSLESV
Sbjct: 301 NTQHAVEAIRPREESLAEKKYTSQGQGDLDSVLSQLNFTHTSEDLLQAEVTCLEGSLESV 360
Query: 361 SATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHL 420
SATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHL
Sbjct: 361 SATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHL 420
Query: 421 TQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMV 480
TQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMV
Sbjct: 421 TQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMV 480
Query: 481 MKLELGLHEAKEISLADLQENYIEALNKLVSENQQLQKDLMNTKSQLEISTQMCKKQNDR 540
MKLELGLHEAKEISLADLQENYIEALNKLVSENQQLQKDLMNTKSQLEISTQMCKKQNDR
Sbjct: 481 MKLELGLHEAKEISLADLQENYIEALNKLVSENQQLQKDLMNTKSQLEISTQMCKKQNDR 540
Query: 541 IFKPTHSRTTEFKNTEFKPTHGQHRHDGIKTEHYKTDLHSPRGQASDSINPMSRVLSPLS 600
IFKPTHSRTTEFKNTEFKPTHGQHRHDGIKTEHYKTDLHSPRGQASDSINPMSRVLSPLS
Sbjct: 541 IFKPTHSRTTEFKNTEFKPTHGQHRHDGIKTEHYKTDLHSPRGQASDSINPMSRVLSPLS 600
Query: 601 PQISPCSSTRSLTSYSLCKTHSLPSALDTNEANFSDTMSESMNDQEEFISSCSLPVSPLG 660
PQISPCSSTRSLTSYSLCKTHSLPSALDTNEANFSDTMSESMNDQEEFISSCSLPVSPLG
Sbjct: 601 PQISPCSSTRSLTSYSLCKTHSLPSALDTNEANFSDTMSESMNDQEEFISSCSLPVSPLG 660
Query: 661 SIATRFLEEEELRSHHILERLDAHIEELKRESEKTVRQFTALK 703
SIATRFLEEEELRSHHILERLDAHIEELKRESEKTVRQFTALK
Sbjct: 661 SIATRFLEEEELRSHHILERLDAHIEELKRESEKTVRQFTALK 703
>gi|109255239 centrosomal protein 63 isoform b [Homo sapiens]
Length = 541
Score = 940 bits (2429), Expect = 0.0
Identities = 497/536 (92%), Positives = 508/536 (94%), Gaps = 10/536 (1%)
Query: 1 MEALLEGIQNRGHGGGFLTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQE 60
MEALLEGIQNRGHGGGFLTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQE
Sbjct: 1 MEALLEGIQNRGHGGGFLTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQE 60
Query: 61 LKSLRSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKK 120
LKSLRSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKK
Sbjct: 61 LKSLRSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKK 120
Query: 121 QMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQ 180
QMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQ
Sbjct: 121 QMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQ 180
Query: 181 SEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGT 240
SEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGT
Sbjct: 181 SEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGT 240
Query: 241 SMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKAT 300
SMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKAT
Sbjct: 241 SMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKAT 300
Query: 301 NTQHAVEAIRPREESLAEKKYTSQGQGDLDSVLSQLNFTHTSEDLLQAEVTCLEGSLESV 360
NTQHAVEAIRPREESLAEKKYTSQGQGDLDSVLSQLNFTHTSEDLLQAEVTCLEGSLESV
Sbjct: 301 NTQHAVEAIRPREESLAEKKYTSQGQGDLDSVLSQLNFTHTSEDLLQAEVTCLEGSLESV 360
Query: 361 SATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHL 420
SATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHL
Sbjct: 361 SATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHL 420
Query: 421 TQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMV 480
TQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMV
Sbjct: 421 TQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMV 480
Query: 481 MKLELGLHEAK-------EISLADLQENYIEA---LNKLVSENQQLQKDLMNTKSQ 526
MKLELGLHE I+ L+E + + L +L + ++L+++ T Q
Sbjct: 481 MKLELGLHECSLPVSPLGSIATRFLEEEELRSHHILERLDAHIEELKRESEKTVRQ 536
Score = 143 bits (360), Expect = 6e-34
Identities = 146/573 (25%), Positives = 253/573 (44%), Gaps = 60/573 (10%)
Query: 137 SEIERLTAKIEEF-RQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKL 195
+E++ L +I+ K +WE + + + E + K+L Q ++ ++ Q++
Sbjct: 23 AELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQV 82
Query: 196 ESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKL 255
E E Q +L++ ++ +C + E+L + M + + +
Sbjct: 83 EEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKK-------QMREFRGNTKNHRED 135
Query: 256 RESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAIRPREES 315
R + L A EE R+ K+ ++ LI++ ++ + Q K A ++ + R++
Sbjct: 136 RSEIERLTAKIEEFRQ-KSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQK 194
Query: 316 LAEKKYTSQGQ-GDLDSVLSQLNFTHTSEDLLQAEVTCLEGSLESVSATCKQLSQELMEK 374
L + +SQ + L S L + N T + +L +T L S T Q Q+ EK
Sbjct: 195 LESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEK 254
Query: 375 YEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHLTQELHQRDITIAST 434
E +++ E K E+K LQ +++ K ++ + + + A
Sbjct: 255 LRESEKLLEALQEEKRELKAA----LQSQENLIHEARIQKEKLQEKVKATNTQHAVEAIR 310
Query: 435 KGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMVMKLELGLHEAKEIS 494
S EK+ ++ Q D + +L H SE +++ E+ E S
Sbjct: 311 PREESLAEKKYTSQGQGDLDSVLS-----------QLNFTHTSEDLLQAEVTCLEG---S 356
Query: 495 LADLQENYIEALNKLVSENQQLQK-DLMNTKSQLEISTQMCKKQNDRIFKPTHSRTTEFK 553
L + + +L+ + ++L++ + N + + EI KK ++I + S ++ +
Sbjct: 357 LESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEI-----KKLKEQILQGEQSYSSALE 411
Query: 554 NTEFKPTHGQHRHDGIKTEHYKTDLH--SPRGQASDSINPMSRVLSPLSPQ-ISPCSSTR 610
+ + +H + E ++ D+ S +G +SD + + + +
Sbjct: 412 GMKMEISH-------LTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILD 464
Query: 611 SLTSYSLCKTHSLPSALDTNEANFSDTMSESMNDQEEFISSCSLPVSPLGSIATRFLEEE 670
L S L H +SE + E + CSLPVSPLGSIATRFLEEE
Sbjct: 465 QLESLKLENRH----------------LSEMVMKLELGLHECSLPVSPLGSIATRFLEEE 508
Query: 671 ELRSHHILERLDAHIEELKRESEKTVRQFTALK 703
ELRSHHILERLDAHIEELKRESEKTVRQFTALK
Sbjct: 509 ELRSHHILERLDAHIEELKRESEKTVRQFTALK 541
>gi|109255226 centrosomal protein 63 isoform c [Homo sapiens]
Length = 495
Score = 828 bits (2139), Expect = 0.0
Identities = 451/536 (84%), Positives = 462/536 (86%), Gaps = 56/536 (10%)
Query: 1 MEALLEGIQNRGHGGGFLTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQE 60
MEALLEGIQNRGHGGGFLTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQE
Sbjct: 1 MEALLEGIQNRGHGGGFLTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQE 60
Query: 61 LKSLRSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKK 120
LKSLRSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKK
Sbjct: 61 LKSLRSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKK 120
Query: 121 QMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQ 180
QMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQ
Sbjct: 121 QMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQ 180
Query: 181 SEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGT 240
SEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGT
Sbjct: 181 SEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGT 240
Query: 241 SMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKAT 300
SMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKAT
Sbjct: 241 SMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKAT 300
Query: 301 NTQHAVEAIRPREESLAEKKYTSQGQGDLDSVLSQLNFTHTSEDLLQAEVTCLEGSLESV 360
NTQHAVEAI SLESV
Sbjct: 301 NTQHAVEAI----------------------------------------------SLESV 314
Query: 361 SATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHL 420
SATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHL
Sbjct: 315 SATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHL 374
Query: 421 TQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMV 480
TQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMV
Sbjct: 375 TQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMV 434
Query: 481 MKLELGLHEAK-------EISLADLQENYIEA---LNKLVSENQQLQKDLMNTKSQ 526
MKLELGLHE I+ L+E + + L +L + ++L+++ T Q
Sbjct: 435 MKLELGLHECSLPVSPLGSIATRFLEEEELRSHHILERLDAHIEELKRESEKTVRQ 490
Score = 138 bits (347), Expect = 2e-32
Identities = 136/512 (26%), Positives = 228/512 (44%), Gaps = 70/512 (13%)
Query: 224 ELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQ---SQE 280
E E++ L +++ +V ++ + E + E L+ ++E + L++ L +
Sbjct: 22 EAELQELMKQIDIMVA------HKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEV 75
Query: 281 NLIHEARIQKEKLQEKVKATNTQ-----HAVEAIRPREESLAEKKYTSQGQGDLDSVLSQ 335
++H+ + EK+++++ Q H I R +KK + +G
Sbjct: 76 GMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRG-------- 127
Query: 336 LNFTHTSEDLLQAEVTCLEGSLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKL 395
N + ED ++E+ L +E ++ + +++ +EA + + +
Sbjct: 128 -NTKNHRED--RSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEII 184
Query: 396 KEQILQGEQSYSSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLR--------- 446
+ Q++ +Q S + EI HL+ +L + + TI + + + R+
Sbjct: 185 QAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTV 244
Query: 447 -AEMQKAEDKAVEHKEILDQLESLKLENRHLSEMVMKLELGLHEAKEISLADLQENYIEA 505
E Q+ E+K E +++L E+L+ E R L + E +HEA+ I LQE ++A
Sbjct: 245 LQEQQQKEEKLRESEKLL---EALQEEKRELKAALQSQENLIHEAR-IQKEKLQEK-VKA 299
Query: 506 LNKLVSENQQLQKDLMNTKSQLEISTQMCKKQNDRIFKPTHSRTTEFKNTEFKPTHGQHR 565
N + + + T QL ++ R+ + E K + + G+
Sbjct: 300 TNTQHAVEAISLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQS 359
Query: 566 H----DGIKTE--HYKTDLH-------SPRGQASDSINPMSRVLSPLSPQ-ISPCSSTRS 611
+ +G+K E H +LH S +G +SD + + + +
Sbjct: 360 YSSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQ 419
Query: 612 LTSYSLCKTHSLPSALDTNEANFSDTMSESMNDQEEFISSCSLPVSPLGSIATRFLEEEE 671
L S L H +SE + E + CSLPVSPLGSIATRFLEEEE
Sbjct: 420 LESLKLENRH----------------LSEMVMKLELGLHECSLPVSPLGSIATRFLEEEE 463
Query: 672 LRSHHILERLDAHIEELKRESEKTVRQFTALK 703
LRSHHILERLDAHIEELKRESEKTVRQFTALK
Sbjct: 464 LRSHHILERLDAHIEELKRESEKTVRQFTALK 495
>gi|109255236 centrosomal protein 63 isoform d [Homo sapiens]
Length = 475
Score = 828 bits (2138), Expect = 0.0
Identities = 443/489 (90%), Positives = 443/489 (90%), Gaps = 46/489 (9%)
Query: 1 MEALLEGIQNRGHGGGFLTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQE 60
MEALLEGIQNRGHGGGFLTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQE
Sbjct: 1 MEALLEGIQNRGHGGGFLTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQE 60
Query: 61 LKSLRSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKK 120
LKSLRSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKK
Sbjct: 61 LKSLRSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKK 120
Query: 121 QMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQ 180
QMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQ
Sbjct: 121 QMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQ 180
Query: 181 SEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGT 240
SEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGT
Sbjct: 181 SEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGT 240
Query: 241 SMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKAT 300
SMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKAT
Sbjct: 241 SMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKAT 300
Query: 301 NTQHAVEAIRPREESLAEKKYTSQGQGDLDSVLSQLNFTHTSEDLLQAEVTCLEGSLESV 360
NTQHAVEAI SLESV
Sbjct: 301 NTQHAVEAI----------------------------------------------SLESV 314
Query: 361 SATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHL 420
SATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHL
Sbjct: 315 SATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHL 374
Query: 421 TQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMV 480
TQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMV
Sbjct: 375 TQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMV 434
Query: 481 MKLELGLHE 489
MKLELGLHE
Sbjct: 435 MKLELGLHE 443
>gi|116812628 coiled-coil domain containing 67 [Homo sapiens]
Length = 604
Score = 228 bits (580), Expect = 2e-59
Identities = 196/707 (27%), Positives = 329/707 (46%), Gaps = 119/707 (16%)
Query: 8 IQNRGHGGGFLTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQ 67
++N+ H + CEAELQELM+QIDIMV++KK +WE + ALET L +R+QEL + ++
Sbjct: 1 MENQAHNTMGTSPCEAELQELMEQIDIMVSNKKMDWERKMRALETRLDLRDQELANAQTC 60
Query: 68 LDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRG 127
LD +EVG+L Q+++ EK MT Y+ +L+ L + L ++EKL+ QM++ +
Sbjct: 61 LDQKGQEVGLLRQKLDSLEKCNLAMTQNYEGQLQSLKAQFSKLTNNFEKLRLHQMKQNKV 120
Query: 128 NTKN----HREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAE---- 179
K E E+ L K+EEFR KS +W+KQ ++YQ + SL+AQ+K L+E
Sbjct: 121 PRKELPHLKEEIPFELSNLNQKLEEFRAKSREWDKQEILYQTHLISLDAQQKLLSEKCNQ 180
Query: 180 ---QSEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVND 236
Q++ Q QL +KQ LE S SEI L + + +E IE+L VN+
Sbjct: 181 FQKQAQSYQTQLNGKKQCLED----SSSEIPRLICDPDPNCEINERDEFIIEKLKSAVNE 236
Query: 237 LVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEK 296
+ S LQ+ E++KLL+ L+ +R+ +A
Sbjct: 237 -IALSRNKLQD---------ENQKLLQELKMYQRQCQAM--------------------- 265
Query: 297 VKATNTQHAVEAIRPREESLAEKKYTSQGQGDLDSVLSQLNFTHTSEDLLQAEVTCLEGS 356
E L+E K Q + DL ++ E L E +G+
Sbjct: 266 ----------------EAGLSEVKSELQSRDDLLRIIEMERLQLHRELLKIGECQNAQGN 309
Query: 357 LESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKME 416
+ ++ +E K +EL + ++ E+ K++ Q+ Q E+ ++S E M+ E
Sbjct: 310 KTRLESSYLPSIKEPERKIKELFSVMQDQPNHEKELNKIRSQLQQVEEYHNSEQERMRNE 369
Query: 417 ISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHL 476
IS LT+ELHQ++ITIA+ ++ +EK+L+ E++ E + K + ++++ EN HL
Sbjct: 370 ISDLTEELHQKEITIATVTKKAALLEKQLKMELEIKEKMLAKQKVSDMKYKAVRTENTHL 429
Query: 477 SEMVMKLELGLHEAKEISLADLQENYIEALNKLVSENQQLQKDLMNTKSQLEISTQMCKK 536
M+ L+ G E + + +++ ++NKL EN++L+ DL ++L +
Sbjct: 430 KGMMGDLDPG--EYMSMDFTNREQSRHTSINKLQYENERLRNDL----AKLHV------- 476
Query: 537 QNDRIFKPTHSRTTEFKNTEFKPTHGQHRHDGIKTEHYKTDLHSPRGQASDSINPMSRVL 596
+ ++T ++ T IK E + L S P +
Sbjct: 477 ---------NGKSTWTNQNTYEETGRYAYQSQIKVEQNEERL-------SHDCEPNRSTM 520
Query: 597 SPLSPQISPCSSTRSLTSYSLCKTHSLPSALDTNEANFSDTMSESMNDQEEFISSCSLPV 656
PL P T +A + S ++D + F S
Sbjct: 521 PPLPP--------------------------STFQA--KEMTSPLVSDDDVFPLSPPDMS 552
Query: 657 SPLGSIATRFLEEEELRSHHILERLDAHIEELKRESEKTVRQFTALK 703
P A FL EEE R+ + + L+ HI+EL+R +E T+ +++ LK
Sbjct: 553 FPASLAAQHFLLEEEKRAKELEKLLNTHIDELQRHTEFTLNKYSKLK 599
>gi|87298937 centrosomal protein 110kDa [Homo sapiens]
Length = 2325
Score = 106 bits (264), Expect = 8e-23
Identities = 144/604 (23%), Positives = 271/604 (44%), Gaps = 69/604 (11%)
Query: 24 ELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLH---- 79
++ E Q+ ++ + E E L K + ELK++ L + + E+ L
Sbjct: 1662 QISERKTQLTLIKQEIEKEEENLQVVLRQMSK-HKTELKNILDMLQLENHELQGLKLQHD 1720
Query: 80 QQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYE---KLQKKQMREFRGNTKNHREDR 136
Q+V E EK Q +E K EL+ L + K E +L ++ RE T R +
Sbjct: 1721 QRVSELEKT-QVAVLEEKLELENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQ 1779
Query: 137 SEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRK--QK 194
S +E L+ + E+ ++K WEK+ ++ +++ E K EQS + + +L RK Q+
Sbjct: 1780 SCVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKM--EQSNLEKLELNVRKLQQE 1837
Query: 195 LESV---ELSSQSEIQHLSSKLERANDTICANELEI----ERLTMRVNDLVGTSM---TV 244
L+ + +LS ++I + +L+ + + + + E+ + L + DL+ T+ +
Sbjct: 1838 LDQLNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVL 1897
Query: 245 LQEQQ----------------QKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARI 288
L EQ QKEE+ ++ + L+ LQ E E K L QE + R+
Sbjct: 1898 LSEQTRLQKDISEWANRFEDCQKEEETKQQQ--LQVLQNEIEENKLKLVQQEMMFQ--RL 1953
Query: 289 QKEKLQEKVKATNTQHAVEAIRPREESLAEKKYTSQGQGDLDSVLSQLNFTHTSEDLLQA 348
QKE+ E+ K ++ ++ ++ EK+ T Q + LD VLS++ LQ
Sbjct: 1954 QKERESEESKLETSKVTLK----EQQHQLEKELTDQ-KSKLDQVLSKVLAAEERVRTLQE 2008
Query: 349 EVTCLEGSLESVSATCKQLS---QELMEKYEELKRMEAHNNEYKAEIKKLKEQIL----Q 401
E E +++S T +QLS Q+L+EK EL ++ + +A+ L+ Q L +
Sbjct: 2009 EERWCESLEKTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRADFSLLRNQFLTERKK 2068
Query: 402 GEQSYSSALEGMKMEISHLTQELHQR-------DITIASTKGSSSDMEKRLRAEMQKAED 454
E+ +S E +K++ S L + L ++ +A+ + + D +R R M++
Sbjct: 2069 AEKQVASLKEALKIQRSQLEKNLLEQKQENSCIQKEMATIELVAQDNHERARRLMKELNQ 2128
Query: 455 KAVEHKEILDQLESLK-LENR--HLSEMVMKLELGLHEAKEISLADLQENYIEA---LNK 508
E+ E+ Q+ + K LE R +S+ + L+ + + SL +L + E L
Sbjct: 2129 MQYEYTELKKQMANQKDLERRQMEISDAMRTLKSEVKDEIRTSLKNLNQFLPELPADLEA 2188
Query: 509 LVSENQQLQKDLMNTKSQLEISTQMCKKQNDRIFKPTHSRTTEFKNTEFKPTHGQHRHDG 568
++ N+ L+ +L + K L + + F H ++ + +HR D
Sbjct: 2189 ILERNENLEGELESLKENLPFTMNEGPFEEKLNFSQVHIMDEHWRGEALREKL-RHREDR 2247
Query: 569 IKTE 572
+K +
Sbjct: 2248 LKAQ 2251
Score = 83.2 bits (204), Expect = 8e-16
Identities = 119/555 (21%), Positives = 240/555 (43%), Gaps = 76/555 (13%)
Query: 22 EAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQ 81
E E++EL ID ++ KKS E L ++ R+Q+ + ++ E+ + +
Sbjct: 1353 EKEMEELHHNIDDLLQEKKS-LECEVEELHRTVQKRQQQKDFIDGNVESLMTEL-EIEKS 1410
Query: 82 VEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREF---RGNTKNHREDRSE 138
++ HE I E+ K LK+ E R ++L + E + TKN E ++
Sbjct: 1411 LKHHEDIVDEIECIEKTLLKRRSE-----LREADRLLAEAESELSCTKEKTKNAVEKFTD 1465
Query: 139 IER----LTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQK 194
+R + EE +++ + + QQ+ SL+A K L EQ +I Q +++ ++
Sbjct: 1466 AKRSLLQTESDAEELERRAQETAVNLVKADQQLRSLQADAKDL-EQHKIKQEEIL---KE 1521
Query: 195 LESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEK 254
+ + + S+ Q LS K E+ + + + +IE + + +
Sbjct: 1522 INKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAE--------------RNEDHHLQV 1567
Query: 255 LRESEKLLEALQEEKRELKAALQSQE-----------------NLIHEARIQ-KEKLQEK 296
L+ESE LL+A + E +LK+ + SQ+ +L+ + +Q K LQE
Sbjct: 1568 LKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEA 1627
Query: 297 VKATNTQHAVEAIRPRE-ESLAEKKYTSQGQGDLDSVLSQLNFTHTSEDLLQAEVTCLEG 355
++ T+ + RE +SL E+ +G+ ++ Q++ T L++ E+ E
Sbjct: 1628 LRLGETEVTEKCNHIREVKSLLEELSFQKGELNV-----QISERKTQLTLIKQEI---EK 1679
Query: 356 SLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKM 415
E++ +Q+S+ E L ++ N+E + + +++ + E++ + LE K+
Sbjct: 1680 EEENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQRVSELEKTQVAVLE-EKL 1738
Query: 416 EISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRH 475
E+ +L Q Q+ KG ++ L + ++ E E + + +E L E
Sbjct: 1739 ELENLQQISQQQ-------KGEIEWQKQLLERDKREIERMTAESRALQSCVECLSKEKED 1791
Query: 476 LSEMVMKLELGLHEAKEISLADLQENYIEALN---------KLVSENQQLQKDLMNTKSQ 526
L E E L + K + A + + +E N KL E QL +D ++ +
Sbjct: 1792 LQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHND 1851
Query: 527 LEISTQMCKKQNDRI 541
+ Q +++ + +
Sbjct: 1852 ISAMQQQLQEKREAV 1866
Score = 82.8 bits (203), Expect = 1e-15
Identities = 108/495 (21%), Positives = 215/495 (43%), Gaps = 54/495 (10%)
Query: 75 VGMLHQQVEEHEKIKQEMTM--EYKQELK-KLHEELCILKRSYEKLQKKQMREFRGNTKN 131
+G+LH V EH ++ E++ + Q LK K EE + R+ ++ +K+M E N +
Sbjct: 1308 MGVLHCNVPEHHNLENEVSRLEDIMQHLKSKKREERWM--RASKRQSEKEMEELHHNIDD 1365
Query: 132 HREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNR 191
+++ +E ++EE + ++Q+ V SL + + E+S +V+
Sbjct: 1366 LLQEKKSLE---CEVEELHRTVQKRQQQKDFIDGNVESLMTELE--IEKSLKHHEDIVDE 1420
Query: 192 KQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQK 251
+ +E L +SE++ L A + + E+ V ++LQ +
Sbjct: 1421 IECIEKTLLKRRSELREADRLLAEAESELSCTK---EKTKNAVEKFTDAKRSLLQTESDA 1477
Query: 252 EEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVK--ATNTQHAVEAI 309
EE R +++ L + ++L+ +LQ+ + + +I++E++ +++ + +
Sbjct: 1478 EELERRAQETAVNLVKADQQLR-SLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCL 1536
Query: 310 RPREESLAEKKYTSQGQGDLDSVLSQLNFTH------TSEDLLQ---AEVTCLEGSLESV 360
++E L E+ Q D +++ N H SE LLQ AE+ L+ + S
Sbjct: 1537 SKKKEKLTEELQKLQ----KDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQ 1592
Query: 361 SATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGE----------QSYSSAL 410
L ++L K EEL ++ + KA+ L+E + GE + S L
Sbjct: 1593 QQEMAVLDRQLGHKKEELHLLQGSMVQAKAD---LQEALRLGETEVTEKCNHIREVKSLL 1649
Query: 411 EGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLK 470
E + + L ++ +R + K E+ L+ +++ E K ILD L+
Sbjct: 1650 EELSFQKGELNVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNILDMLQ--- 1706
Query: 471 LENRHLSEMVMKLELGLHEAKEISLADLQENYIEALNKLVSENQQLQKDLMNTKSQLEIS 530
LEN L + ++ + + E ++ +A L+E KL EN LQ+ K ++E
Sbjct: 1707 LENHELQGLKLQHDQRVSELEKTQVAVLEE-------KLELEN--LQQISQQQKGEIEWQ 1757
Query: 531 TQMCKKQNDRIFKPT 545
Q+ ++ I + T
Sbjct: 1758 KQLLERDKREIERMT 1772
Score = 73.2 bits (178), Expect = 8e-13
Identities = 115/510 (22%), Positives = 209/510 (40%), Gaps = 90/510 (17%)
Query: 50 LETCLKIREQELKSLRSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCI 109
L+T L+ +E+++ + +++L H E+ QQ+ + +E K+L EE
Sbjct: 435 LDTQLEDKEKKISAAQTRLSELHDEIEKAEQQI-----------LRATEEFKQL-EEAIQ 482
Query: 110 LKRSYEKLQKKQMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSS 169
LK+ E + ++ G + + R E L ++E+ +Q+ +K+ Q + S
Sbjct: 483 LKKISEAGKDLLYKQLSGRLQLVNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAIDS 542
Query: 170 LE----------AQRKALAEQSEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERAND- 218
L+ AQ+ +Q +I+ Q + +L+ + E + + E+ +
Sbjct: 543 LDSKDPKHSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEG 602
Query: 219 TICANEL---EIERLTMRVNDLVGTSMTVLQEQQQKEEKLR-ESEKLLEAL---QEEKRE 271
I ANE ++E + + + +GT + Q + KLR E E LL+ L ++E+ +
Sbjct: 603 QIAANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQ 662
Query: 272 LKAALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAIRPREESLAEKKYTSQGQGDLDS 331
L+ EN+ +++L E A QH V A Q QGDL +
Sbjct: 663 LEIVAMDAENM-------RKELAELESALQEQHEVNA------------SLQQTQGDLSA 703
Query: 332 VLSQLNFTHTSEDLLQAEVTCLEGSLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAE 391
++L +L AE L+ LE V+ QL Q ++ E +R N KA+
Sbjct: 704 YEAEL---EARLNLRDAEANQLKEELEKVT-RLTQLEQSALQAELEKERQALKNALGKAQ 759
Query: 392 IKKLKEQILQGEQSYSSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQK 451
+ KEQ E S ELH + + K + +
Sbjct: 760 FSEEKEQ----ENS-----------------ELHAKLKHLQDDNNLLKQQLKDFQNHLNH 798
Query: 452 AEDKAVEHKEILDQLESLKLENRHLSEMVMKL---ELGLHEAKEI---SLADLQENYIEA 505
D V +E+ +++ L+ + +KL E+ +H ++ SLADLQ+ + E
Sbjct: 799 VVDGLVRPEEVAARVDELRRK--------LKLGTGEMNIHSPSDVLGKSLADLQKQFSEI 850
Query: 506 LNKLVSENQQLQKDLMNTKSQLEISTQMCK 535
L + E + Q + K Q E++ Q K
Sbjct: 851 LARSKWERDEAQ--VRERKLQEEMALQQEK 878
Score = 68.9 bits (167), Expect = 1e-11
Identities = 116/566 (20%), Positives = 246/566 (43%), Gaps = 68/566 (12%)
Query: 56 IREQELKSLRSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYE 115
I +ELKS +++ K L++ ++E ++++ E K +L +E +LK+
Sbjct: 284 IETEELKSKQTRFLEEIKNQDKLNKSLKEEAMLQKQSCEELKSDLNTKNE---LLKQKTI 340
Query: 116 KLQKKQMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQ--VSSLEAQ 173
+L + +++ E ++ AK E ++ + + + +
Sbjct: 341 ELTRACQKQYE------LEQELAFYKIDAKFEPLNYYPSEYAEIDKAPDESPYIGKSRYK 394
Query: 174 RKALAEQSEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMR 233
R A +S II + + +K+E E Q H++ + DT ++E +
Sbjct: 395 RNMFATESYIIDSAQAVQIKKMEPDE---QLRNDHMNLRGHTPLDT------QLEDKEKK 445
Query: 234 VNDLVGTSMTVLQEQQQKEEK--LRESEKLLEALQEEKRELKAALQSQENLIHEARIQKE 291
++ T ++ L ++ +K E+ LR +E+ + EE +LK ++ ++L+++ +
Sbjct: 446 IS-AAQTRLSELHDEIEKAEQQILRATEEFKQL--EEAIQLKKISEAGKDLLYKQLSGRL 502
Query: 292 KLQEKVKATNTQHAVEAIRPREESLAEKKYTSQGQGDLDSVLSQLNFTHTSEDLLQAEVT 351
+L K++ ++ + ++E ++K DL + L+ ++A+ +
Sbjct: 503 QLVNKLRQEALDLELQMEKQKQEIAGKQKEIK----DLQIAIDSLDSKDPKHSHMKAQKS 558
Query: 352 CLEGSLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALE 411
E L+ ++ +QL L +E+ A E EIK L+EQ+ +G+ +A E
Sbjct: 559 GKEQQLDIMNKQYQQLESRL----DEILSRIAKETE---EIKDLEEQLTEGQ---IAANE 608
Query: 412 GMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKL 471
+K ++ + L + TI + + ++LR E + + E ++ DQLE + +
Sbjct: 609 ALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVAM 668
Query: 472 ENRHLSEMVMKLELGLHEAKEISLADLQ---------ENYIEA-LNKLVSENQQLQKDL- 520
+ ++ + + +LE L E E++ A LQ E +EA LN +E QL+++L
Sbjct: 669 DAENMRKELAELESALQEQHEVN-ASLQQTQGDLSAYEAELEARLNLRDAEANQLKEELE 727
Query: 521 -MNTKSQLEISTQMCKKQNDR------IFKPTHSRTTEFKNTEFKPTHGQHRHDGIKTEH 573
+ +QLE S + + +R + K S E +N+E K +H
Sbjct: 728 KVTRLTQLEQSALQAELEKERQALKNALGKAQFSEEKEQENSELH----------AKLKH 777
Query: 574 YKTDLHSPRGQASDSINPMSRVLSPL 599
+ D + + Q D N ++ V+ L
Sbjct: 778 LQDDNNLLKQQLKDFQNHLNHVVDGL 803
Score = 68.6 bits (166), Expect = 2e-11
Identities = 77/399 (19%), Positives = 175/399 (43%), Gaps = 49/399 (12%)
Query: 18 LTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLD----VTHK 73
L E+ LQE +++ + + + LE L +R+ E L+ +L+ +T
Sbjct: 677 LAELESALQE-QHEVNASLQQTQGDLSAYEAELEARLNLRDAEANQLKEELEKVTRLTQL 735
Query: 74 EVGMLHQQVEEHEKI------KQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRG 127
E L ++E+ + K + + E +QE +LH +L L+ L K+Q+++F+
Sbjct: 736 EQSALQAELEKERQALKNALGKAQFSEEKEQENSELHAKLKHLQDD-NNLLKQQLKDFQN 794
Query: 128 NTKNHREDRSEIERLTAKIEEFRQK------SLDWEKQRLIYQQQVSSLEAQRKALAEQS 181
+ + + E + A+++E R+K ++ + + ++ L+ Q + +S
Sbjct: 795 HLNHVVDGLVRPEEVAARVDELRRKLKLGTGEMNIHSPSDVLGKSLADLQKQFSEILARS 854
Query: 182 EIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTS 241
+ + + R++KL+ Q ++ + +A C LE R+N
Sbjct: 855 KWERDEAQVRERKLQEEMALQQEKLATGQEEFRQA----CERALEA-----RMNF----- 900
Query: 242 MTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATN 301
+++Q E ++++ E + LQE + ++ + + EA +KE++ +++
Sbjct: 901 -----DKRQHEARIQQMENEIHYLQENLKSMEEIQGLTDLQLQEADEEKERILAQLRELE 955
Query: 302 TQHAVEAIRPREESLAEKKYTSQGQGDLDSVLSQLN-FTHTSEDLLQAEVTCLEGSLESV 360
+ +E + +E+ LD L +L TS+ L AE+T + L+S+
Sbjct: 956 KKKKLEDAKSQEQVFG-----------LDKELKKLKKAVATSDKLATAELTIAKDQLKSL 1004
Query: 361 SATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQI 399
T +++QE E+ +E +R + ++ + + +I
Sbjct: 1005 HGTVMKINQERAEELQEAERFSRKAAQAARDLTRAEAEI 1043
Score = 63.5 bits (153), Expect = 6e-10
Identities = 82/354 (23%), Positives = 153/354 (43%), Gaps = 33/354 (9%)
Query: 39 KKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQ 98
+ E R L LK+ E+ ++ S DV K + L +Q E + E +
Sbjct: 805 RPEEVAARVDELRRKLKLGTGEM-NIHSPSDVLGKSLADLQKQFSEILARSKWERDEAQV 863
Query: 99 ELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDRSEIERLT--AKIEEFRQKSLDW 156
+KL EE+ + + EKL Q EFR + E R ++ A+I++ + + +
Sbjct: 864 RERKLQEEMALQQ---EKLATGQ-EEFRQACERALEARMNFDKRQHEARIQQM-ENEIHY 918
Query: 157 EKQRLIYQQQVSSL-EAQRKALAEQSEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLER 215
++ L +++ L + Q + E+ E I AQL ++K + + SQ ++ L +L++
Sbjct: 919 LQENLKSMEEIQGLTDLQLQEADEEKERILAQLRELEKKKKLEDAKSQEQVFGLDKELKK 978
Query: 216 ANDTICANE-LEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKA 274
+ ++ L LT+ + L TV++ Q++ E+L+E+E+ + R+L
Sbjct: 979 LKKAVATSDKLATAELTIAKDQLKSLHGTVMKINQERAEELQEAERFSRKAAQAARDLTR 1038
Query: 275 ALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAIRPREESLAEKKYTSQGQGDLDSVLS 334
A EA I E LQ ++ Q + E + T G G VL
Sbjct: 1039 A---------EAEI--ELLQNLLRQKGEQFRL-----------EMEKTGVGTGANSQVLE 1076
Query: 335 QLNFTHTSEDLLQAEVTCLEGSLESVSATCKQLSQELMEKYEELKRMEAHNNEY 388
T E + E+ L+ L+ + K + ++E+ EL+R ++ N+Y
Sbjct: 1077 IEKLNETME-RQRTEIARLQNVLDLTGSDNKGGFENVLEEIAELRREVSYQNDY 1129
Score = 61.2 bits (147), Expect = 3e-09
Identities = 97/492 (19%), Positives = 205/492 (41%), Gaps = 61/492 (12%)
Query: 22 EAELQELMKQIDIMVAH--KKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLH 79
+ E+++L ID + + K S + + E L I ++ + L S+LD +
Sbjct: 530 QKEIKDLQIAIDSLDSKDPKHSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKET 589
Query: 80 QQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNH-REDRSE 138
+++++ E+ E + + LKK E + ++E+ G K + ++E
Sbjct: 590 EEIKDLEEQLTEGQIAANEALKKDLEGVI-----------SGLQEYLGTIKGQATQAQNE 638
Query: 139 IERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESV 198
+L + E Q+ + E++R + E RK LAE +Q Q ++ +
Sbjct: 639 CRKLRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKELAELESALQEQ-----HEVNAS 693
Query: 199 ELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRES 258
+Q ++ ++LE + A +++ +V L + LQ + +KE + ++
Sbjct: 694 LQQTQGDLSAYEAELEARLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKERQALKN 753
Query: 259 EKLLEALQEEKRELKAALQSQ-ENLIHEARIQKEKLQEKVKATNTQHAVEAIRPREESLA 317
EEK + + L ++ ++L + + K++L++ N H V+ + EE A
Sbjct: 754 ALGKAQFSEEKEQENSELHAKLKHLQDDNNLLKQQLKDFQNHLN--HVVDGLVRPEEVAA 811
Query: 318 E----KKYTSQGQGDLDSVLSQLNFTHTSEDLLQAEVTCLEGSLESVSATCKQLSQELME 373
++ G G+++ H+ D+L + L+ + A K E
Sbjct: 812 RVDELRRKLKLGTGEMN--------IHSPSDVLGKSLADLQKQFSEILARSKWERDEAQV 863
Query: 374 KYEELKRMEAHNNEYKA----EIKKLKEQILQG-----EQSYSSALEGMKMEISHLTQEL 424
+ +L+ A E A E ++ E+ L+ ++ + + ++ M+ EI +L + L
Sbjct: 864 RERKLQEEMALQQEKLATGQEEFRQACERALEARMNFDKRQHEARIQQMENEIHYLQENL 923
Query: 425 HQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESL----KLENRHLSEMV 480
S +++ ++Q+A++ E + IL QL L KLE+ E V
Sbjct: 924 K-----------SMEEIQGLTDLQLQEADE---EKERILAQLRELEKKKKLEDAKSQEQV 969
Query: 481 MKLELGLHEAKE 492
L+ L + K+
Sbjct: 970 FGLDKELKKLKK 981
Score = 61.2 bits (147), Expect = 3e-09
Identities = 80/401 (19%), Positives = 161/401 (40%), Gaps = 56/401 (13%)
Query: 227 IERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQ-------EEKRELKAALQSQ 279
+E R+ D++ + +E++ R+SEK +E L +EK+ L+ ++
Sbjct: 1321 LENEVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEEL 1380
Query: 280 ENLIHEARIQKEKLQEKVKATNTQHAVE-------------------AIRPREESLAEKK 320
+ + + QK+ + V++ T+ +E ++ R E +
Sbjct: 1381 HRTVQKRQQQKDFIDGNVESLMTELEIEKSLKHHEDIVDEIECIEKTLLKRRSELREADR 1440
Query: 321 YTSQGQGDLDSVLSQL-----NFTHTSEDLLQAEVTC--LEGSLESVSATCKQLSQELME 373
++ + +L + FT LLQ E LE + + + Q+L
Sbjct: 1441 LLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVKADQQLRS 1500
Query: 374 KYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHLTQELHQRDITIAS 433
+ K +E H + + EI K +I+ + S L K +++ Q+L Q+DI +A
Sbjct: 1501 LQADAKDLEQHKIK-QEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKL-QKDIEMAE 1558
Query: 434 TK--------GSSSDMEKRLRAEMQKAEDKAVEHKE---ILDQLESLKLENRHLSE-MVM 481
S + + RAE++K + + ++ +LD+ K E HL + ++
Sbjct: 1559 RNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMV 1618
Query: 482 KLELGLHEAKEISLADLQE--NYIEALNKLVSE----NQQLQKDLMNTKSQLEISTQMCK 535
+ + L EA + ++ E N+I + L+ E +L + K+QL + Q +
Sbjct: 1619 QAKADLQEALRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQISERKTQLTLIKQEIE 1678
Query: 536 KQNDR---IFKPTHSRTTEFKNTEFKPTHGQHRHDGIKTEH 573
K+ + + + TE KN H G+K +H
Sbjct: 1679 KEEENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQH 1719
Score = 42.7 bits (99), Expect = 0.001
Identities = 120/577 (20%), Positives = 236/577 (40%), Gaps = 120/577 (20%)
Query: 55 KIREQELKSLRSQLDVT-HKEVGMLHQQVEEHEK-IKQEMT---------MEYKQELKKL 103
K+ +Q+ +L L+++ K+ G + +E EK +K E+ +E +L KL
Sbjct: 90 KLTKQDNLALIKSLNLSLSKDGGKKFKYIENLEKCVKLEVLNLSYNLIGKIEKLDKLLKL 149
Query: 104 HEELCILKRSYEKLQKKQMREFRGNTKNHREDRSEIERLTA----KIEEFRQKSLDWEKQ 159
E L SY K+ K + E N + +EIE + K++ R +L K
Sbjct: 150 RE----LNLSYNKISKIEGIENMCNLQKLNLAGNEIEHIPVWLGKKLKSLRVLNLKGNK- 204
Query: 160 RLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESVELSSQSEIQHLSS--KLERAN 217
+SSL+ K L ++I LV + + ++ Q I HL S LE
Sbjct: 205 -------ISSLQDISK-LKPLQDLISLILV--ENPVVTLPHYLQFTIFHLRSLESLEGQP 254
Query: 218 DTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQ 277
T + ER ++ V + ++ E+K+ E+E+L E+K +
Sbjct: 255 VTTQDRQEAFERFSLE---------EVERLERDLEKKMIETEELKSKQTRFLEEIKNQDK 305
Query: 278 SQENLIHEARIQKEKLQEKVKATNTQHAVEAIRPREESLA-EKKYTSQGQ---GDLDSVL 333
++L EA +QK+ +E NT++ + + E + A +K+Y + + +D+
Sbjct: 306 LNKSLKEEAMLQKQSCEELKSDLNTKNELLKQKTIELTRACQKQYELEQELAFYKIDAKF 365
Query: 334 SQLNF--------------------THTSEDLLQAEVTCLEGSLESVSATCKQ------- 366
LN+ + ++ E ++ S ++V +
Sbjct: 366 EPLNYYPSEYAEIDKAPDESPYIGKSRYKRNMFATESYIID-SAQAVQIKKMEPDEQLRN 424
Query: 367 ----------LSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKM- 415
L +L +K +++ + +E EI+K ++QIL+ + + E +++
Sbjct: 425 DHMNLRGHTPLDTQLEDKEKKISAAQTRLSELHDEIEKAEQQILRATEEFKQLEEAIQLK 484
Query: 416 EISHLTQELHQRDIT-----IASTKGSSSDMEKRLRAEMQKAEDKAVEHKEI---LDQLE 467
+IS ++L + ++ + + + D+E ++ + Q+ K E K++ +D L+
Sbjct: 485 KISEAGKDLLYKQLSGRLQLVNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAIDSLD 544
Query: 468 SLKLENRH--------------LSEMVMKLELGLHE-----AKEI-SLADLQENYIEALN 507
S ++ H +++ +LE L E AKE + DL+E E
Sbjct: 545 SKDPKHSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEG-- 602
Query: 508 KLVSENQQLQKDLMNTKSQLE-----ISTQMCKKQND 539
++ N+ L+KDL S L+ I Q + QN+
Sbjct: 603 -QIAANEALKKDLEGVISGLQEYLGTIKGQATQAQNE 638
Score = 33.1 bits (74), Expect = 0.90
Identities = 52/235 (22%), Positives = 90/235 (38%), Gaps = 26/235 (11%)
Query: 2 EALLEGIQNRGHGGGFLTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQEL 61
EA ++ ++N H +L ++E+ D+ + E E L K ++ E
Sbjct: 906 EARIQQMENEIH---YLQENLKSMEEIQGLTDLQLQEADEEKERILAQLRELEKKKKLED 962
Query: 62 KSLRSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLH-------EELCILKRSY 114
+ Q+ KE+ L + V +K+ K +LK LH +E +
Sbjct: 963 AKSQEQVFGLDKELKKLKKAVATSDKLATAELTIAKDQLKSLHGTVMKINQERAEELQEA 1022
Query: 115 EKLQKKQMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEK---------QRLIYQQ 165
E+ +K + R T+ E L K E+FR L+ EK Q L ++
Sbjct: 1023 ERFSRKAAQAARDLTRAEAEIELLQNLLRQKGEQFR---LEMEKTGVGTGANSQVLEIEK 1079
Query: 166 QVSSLEAQRKALAEQSEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTI 220
++E QR +A ++ + K E+V EI L ++ ND I
Sbjct: 1080 LNETMERQRTEIARLQNVLDLTGSDNKGGFENV----LEEIAELRREVSYQNDYI 1130
>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 668
Score = 102 bits (253), Expect = 2e-21
Identities = 93/385 (24%), Positives = 188/385 (48%), Gaps = 37/385 (9%)
Query: 39 KKSEWEGRTHALETCL-----KIREQELKSLRSQLDVTHKEVGMLHQQV---EEHEKIK- 89
K EWE + E + KIREQE K R + + KE M Q+ E+ EK++
Sbjct: 308 KIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRR 367
Query: 90 -QEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDRSEIERLTAKIEE 148
+EM E ++++++L E++ ++ E+ +K+Q E + +E +++ R KI E
Sbjct: 368 LEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIRE 427
Query: 149 FRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKL-ESVELSSQSEIQ 207
+K + EK+ +Q + Q K E+ Q ++ +++K+ E E+ Q E
Sbjct: 428 QEEKIREQEKK---MWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKM 484
Query: 208 HLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQ--QKEEKLRESEKLLEAL 265
H K+ + + + E ++ ++ + QE++ ++EEK+RE E+ +
Sbjct: 485 HEQEKIRKQEEKVWRQEEKMHDQEEKIRE---------QEEKMWRQEEKIREQEEKIREQ 535
Query: 266 QEEKRELKAALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAIRPREESLAEKKYTSQG 325
+E+ RE + +Q QE + E Q+EK+QE+ K + E IR +EE + E+K +
Sbjct: 536 EEKIREQEEMMQEQEEKMGE---QEEKMQEQEKMRRQE---EKIREQEEKIREQKEKIRE 589
Query: 326 QGDLDSVLSQLNFTHTSEDLLQAEVTCLEGSLESVSATCKQLSQELMEKYEELKRMEAHN 385
Q + + Q E+++Q + E E C+Q +++ E+ E+++R E
Sbjct: 590 QE--EKIWEQEEKIREQEEMMQEQE---EKMWEQEEKMCEQ-EEKMQEQEEKMRRQEEKM 643
Query: 386 NEYKAEIKKLKEQILQGEQSYSSAL 410
E + +++ +E++ + ++ +A+
Sbjct: 644 WEQEVRLRQQEEKMQEHQEHLEAAI 668
Score = 72.0 bits (175), Expect = 2e-12
Identities = 101/535 (18%), Positives = 232/535 (43%), Gaps = 55/535 (10%)
Query: 45 GRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQVEE-------HEKIKQEMTMEYK 97
G H+ E K Q ++LR +L+ + +L Q E + +++ E +
Sbjct: 102 GGCHSPEDEQKASHQHQEALRRELEAQVHTIRILTCQKTELQMALYYSQHAVKQLEGEAR 161
Query: 98 QELKKLHE------ELCILKRSYEKLQKKQMREFRGNTKNHREDRSEIERLTAKIEEFRQ 151
+ +LH+ EL + +KK R TK E+ R T EE ++
Sbjct: 162 DLISRLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKE 221
Query: 152 KSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESVELSSQSEIQHLSS 211
K+ +++ + + + S ++ K L + E +A+L+ +Q+L++ E+Q +S+
Sbjct: 222 KNAKLQEKLQLVESEKSEIQLNVKELKRKLE--RAKLLLPQQQLQAEADHLGKELQSVSA 279
Query: 212 KLE-RANDTICANEL--EIERLTMRVNDLVGTSMTVLQEQQQK----EEKLRESEKLLEA 264
KL+ + + N L + E R + + +QEQ++K EEK+RE E+ +
Sbjct: 280 KLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRR 339
Query: 265 LQEEKRELKAALQSQENLIHEARIQKEKLQEKV--------KATNTQHAVEAIRPREESL 316
+E E + ++ QE ++ E + +L+E + + H E IR +EE
Sbjct: 340 QEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQEEKR 399
Query: 317 AEKKYTSQGQGDLDSVLSQLNFTHTSEDLLQAEVTCLEGSLESVSATCKQLSQELMEKYE 376
E++ + + + + E + + E E + K++ ++ + +E
Sbjct: 400 QEEEKIREQEKRQEQ---EAKMWRQEEKIREQE--------EKIREQEKKMWRQEEKIHE 448
Query: 377 ELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHLTQELHQRDITIASTKG 436
+ K E + + E+ + +E+I + E+ + + E H +++ +++ + +
Sbjct: 449 QEKIREEEKRQEQEEMWRQEEKIREQEEIWR------QKEKMHEQEKIRKQEEKVWRQEE 502
Query: 437 SSSDMEKRLRAE---MQKAEDKAVEHKE-ILDQLESLKLENRHLSEMVMKLELGLHEAKE 492
D E+++R + M + E+K E +E I +Q E ++ + + E K+ + +E
Sbjct: 503 KMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQE 562
Query: 493 ISLADLQENYIEALNKLVSEN----QQLQKDLMNTKSQLEISTQMCKKQNDRIFK 543
QE I + + E ++ ++ + + ++ +M ++Q +++++
Sbjct: 563 QEKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQEEKIREQEEMMQEQEEKMWE 617
Score = 69.7 bits (169), Expect = 9e-12
Identities = 75/306 (24%), Positives = 143/306 (46%), Gaps = 34/306 (11%)
Query: 2 EALLEGIQNRGHGGGFLTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQEL 61
E + ++ + H + E + QE K I K+ E E + E KIREQE
Sbjct: 376 EEKIRELEEKMHEQEKIREQEEKRQEEEK---IREQEKRQEQEAKMWRQEE--KIREQEE 430
Query: 62 KSLRSQLDVTHKEVGMLHQQ--VEEHEKIKQEMTMEYKQELKKLHEELCILK---RSYEK 116
K +R Q ++ +H+Q + E EK +++ M ++E + EE+ K EK
Sbjct: 431 K-IREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEK 489
Query: 117 LQKKQMREFRGNTKNHRED---RSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQ 173
++K++ + +R K H ++ R + E++ + E+ R++ +Q ++Q ++ Q
Sbjct: 490 IRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQ 549
Query: 174 RKALAEQSEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMR 233
+ + EQ E +Q Q R+Q+ + E + +I+ K+ + I E +I
Sbjct: 550 EEKMGEQEEKMQEQEKMRRQEEKIRE--QEEKIREQKEKIREQEEKIWEQEEKIRE---- 603
Query: 234 VNDLVGTSMTVLQEQQQK----EEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQ 289
++QEQ++K EEK+ E E+ ++ +E+ R + + QE + R Q
Sbjct: 604 -------QEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRL---RQQ 653
Query: 290 KEKLQE 295
+EK+QE
Sbjct: 654 EEKMQE 659
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 102 bits (253), Expect = 2e-21
Identities = 145/723 (20%), Positives = 317/723 (43%), Gaps = 99/723 (13%)
Query: 2 EALLEGIQNRGHGGGFLTSCEAELQELMKQI--DIMVAHKKSEW--EGRTHALETCLKIR 57
EA+ + + GHGG + + + L++Q D+ + K+ +W E LE ++
Sbjct: 61 EAVHDAGNDSGHGGESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQ 120
Query: 58 EQELKSLRSQLDVTHKEVGMLHQQVEEHE----KIKQEMTMEYKQELKKLHEELCILKRS 113
+QE K D + E+ L QQ+EE + IKQ + ++Q+ +L E+ +K
Sbjct: 121 QQEAKPDGLVTD-SSAELQSLEQQLEEAQTENFNIKQMKDL-FEQKAAQLATEIADIKSK 178
Query: 114 YEKLQKKQMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQ 173
Y+ +++ +RE ++ RLT ++ + D K L+ + + +
Sbjct: 179 YD--EERSLREAA---------EQKVTRLTEELNKEATVIQDL-KTELLQRPGIEDVAVL 226
Query: 174 RKALAEQSEIIQAQLVNRKQ----------KLESVELSSQSEIQHLSSKLERANDTICAN 223
+K L + ++ + R++ KL+S SS++ I L S+L + +
Sbjct: 227 KKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVY 286
Query: 224 ELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLI 283
E+++L VN+L Q+ Q E L + E+ L+E+ E + ++ + +
Sbjct: 287 VQELQKLKSSVNELT-------QKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATL 339
Query: 284 HEARIQKEKLQEKVKATNTQ-HAVEAIRPREESLAEKKYTSQGQGDLDSVLSQLNFTHTS 342
H+ + ++LQ ++ A+ T H + L+EK +Q
Sbjct: 340 HQKDLDCQQLQSRLSASETSLHRIHV------ELSEKGEATQ------------------ 375
Query: 343 EDLLQAEVTCLEGSLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQG 402
L+ E++ +E + + A KQL Q+ EK E H + ++EI +L ++L+
Sbjct: 376 --KLKEELSEVETKYQHLKAEFKQLQQQREEK-------EQHGLQLQSEINQLHSKLLET 426
Query: 403 EQSYSSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLR------AEMQKAEDKA 456
E+ A +K + +++L ++ +A + S +E++L+ E+Q DK
Sbjct: 427 ERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKT 486
Query: 457 V---EHKEILDQLESLKL-ENRHLSEMVMKLELGLHEAKEISLADLQENYIEALNKLVSE 512
+ ++ L Q + KL E ++ E V++ ++G + K +L L + E ++ L E
Sbjct: 487 KQQHQEQQALQQSTTAKLREAQNDLEQVLR-QIGDKDQKIQNLEALLQKSKENISLLEKE 545
Query: 513 NQQLQKDLMNTKSQLEISTQMCKKQNDRIFKPTHSRTTEFKN-TEFKPTHGQHRHDGIKT 571
+ L + + + + Q+ +++N + + T + KN +E ++ HD ++
Sbjct: 546 REDLYAKIQAGEGETAVLNQL-QEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQE 604
Query: 572 EHYKTDLHSPRGQA---SDSINPMSRVLSPLSPQISPCSSTRSLTSYSLCKTHSLPSALD 628
+ K L + + + S+N ++ L+ ++S + L + +A
Sbjct: 605 Q--KAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQR 662
Query: 629 TNEANFSDTMSESMNDQEEFISSCSLPVSPLGSIATRFLEEEELRSHHILERLDAHIEEL 688
+ N DT ++ D+++ ++ + + L + + +++E S +L++H++E
Sbjct: 663 ADLQNHLDTAQNALQDKQQELNKIT---TQLDQVTAKLQDKQEHCS-----QLESHLKEY 714
Query: 689 KRE 691
K +
Sbjct: 715 KEK 717
Score = 92.8 bits (229), Expect = 1e-18
Identities = 112/515 (21%), Positives = 239/515 (46%), Gaps = 56/515 (10%)
Query: 25 LQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQVEE 84
+++ + ++ + + KSE+E + + E+ K L+ QL V + +++++
Sbjct: 858 VKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKK 917
Query: 85 HEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNT----KNHREDRSEIE 140
+ ++E + + K EL + E+L I ++ K +K+ ++ +GN ++ + + +IE
Sbjct: 918 SLEKEKEASHQLKLELNSMQEQL-IQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIE 976
Query: 141 RLTA--KIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALA------EQSEIIQAQLVNRK 192
L KI ++ L+ + Q+ + Q L A+++ ++ E+S+ QL +
Sbjct: 977 ALQGELKIAVLQKTELENKLQQQL-TQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDF 1035
Query: 193 QKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKE 252
ES L+++ +++ + KL A + + +N +I + +L T+ Q+ +KE
Sbjct: 1036 YGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKE 1095
Query: 253 EKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAIRPR 312
++L+E K L+ +Q+EK LK ++ L++E K KL E +E I+ R
Sbjct: 1096 QQLQERCKALQDIQKEK-SLK-----EKELVNE----KSKLAE----------IEEIKCR 1135
Query: 313 EESLAEKKYTSQGQGDLDSVLSQLNFTHTSEDLLQAEVTCLEGSLESVSATCKQLSQELM 372
+E K L+S+ N + L+Q ++ L+G +S+ A +Q
Sbjct: 1136 QEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLE-LQGKADSLKAAVEQ------ 1188
Query: 373 EKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALE----GMKMEISH---LTQELH 425
E + + ++ K E ++LK++ ++ E S ++ GMK + LT ++
Sbjct: 1189 ----EKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQIT 1244
Query: 426 QRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMVMKLEL 485
+ + + K ++R+ ++ +D E + +++ + E R L E +K E
Sbjct: 1245 ALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGE- 1303
Query: 486 GLHEAKEISLADLQ---ENYIEALNKLVSENQQLQ 517
G E + + +LQ +N A+ +L ENQ LQ
Sbjct: 1304 GEIEKLQTKVLELQRKLDNTTAAVQELGRENQSLQ 1338
Score = 90.5 bits (223), Expect = 5e-18
Identities = 148/726 (20%), Positives = 309/726 (42%), Gaps = 98/726 (13%)
Query: 27 ELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQVEEHE 86
EL+ + ++++ + + L+ ++QEL + +QLD +V Q +EH
Sbjct: 649 ELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLD----QVTAKLQDKQEHC 704
Query: 87 KIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDRSEIERLTAKI 146
+ EYK++ L ++ L+ +KL+ + E + + + +D + +L +
Sbjct: 705 SQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSL-EVKASKEQALQDLQQQRQLNTDL 763
Query: 147 E---EFRQKSLDWEKQ-----RLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESV 198
E K L+ EK+ RL Q++ +LE+ ++ L +Q E + Q++ KQ E+
Sbjct: 764 ELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEE--EKQIL--KQDFET- 818
Query: 199 ELSSQSEIQHLSSKLERANDTICANELEIERLTM-----------------RVNDLVGTS 241
LS +++IQH E N+ I E++++ M +V+D + S
Sbjct: 819 -LSQETKIQH-----EELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNS 872
Query: 242 MTVLQEQQQK--------EEKLRESEKLLEALQE----EKRELKAALQSQENLIHEARIQ 289
+ +++ QK E+ +E + L+ E E++ELK +L+ ++ H+ +++
Sbjct: 873 KSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLE 932
Query: 290 KEKLQEK-VKATNTQHAVEAIRP---------REESLAEKKYTSQGQGDLDSVLSQLNFT 339
+QE+ ++A NT E ++ S +KK QG+L + Q
Sbjct: 933 LNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKT-- 990
Query: 340 HTSEDLLQAEVTCLEGSLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQI 399
E+ LQ ++T L + L + E K++++ ++E+ ++ +
Sbjct: 991 -ELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDL 1049
Query: 400 LQGEQSYSSALEGM---KMEISH---LTQELHQRDITIASTKG-SSSDMEKRLRAEMQKA 452
E+ S A E + + +I + L QEL T+ +++R +A
Sbjct: 1050 KSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQ 1109
Query: 453 EDKAVEHKEILDQLESL----KLENRHLSEMVMKLELGLHEAKEISLADLQENYIEALNK 508
++K+++ KE++++ L +++ R E + KL L K S+ ++ N +A
Sbjct: 1110 KEKSLKEKELVNEKSKLAEIEEIKCRQEKE-ITKLNEELKSHKLESIKEI-TNLKDAKQL 1167
Query: 509 LVSENQQLQKDLMNTKSQLEISTQMCKKQNDRIFKPTHSRTTEFKNTEFKPTHGQHRHDG 568
L+ + +LQ + K+ +E +K+N +I K + E EF + H
Sbjct: 1168 LIQQKLELQGKADSLKAAVE-----QEKRNQQILKDQVKKEEEELKKEFIEKEAK-LHSE 1221
Query: 569 IKTEHYKTDLHSP-RGQASDSINPMSRVLSPLSPQISPCSSTRSLTSYSLCKTHSLPSAL 627
IK + H + + I ++ L + + SS R ++ +T L +
Sbjct: 1222 IKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQ--SSQRRVSELEK-QTDDLRGEI 1278
Query: 628 DTNEANFSDTMSESMNDQEEFISSCSLPVSPLGSIATRFLEEEELRSHHILERLDAHIEE 687
EA T+ + +++ + C + + T+ LE + L+ A ++E
Sbjct: 1279 AVLEA----TVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRK-----LDNTTAAVQE 1329
Query: 688 LKRESE 693
L RE++
Sbjct: 1330 LGRENQ 1335
Score = 85.1 bits (209), Expect = 2e-16
Identities = 110/529 (20%), Positives = 231/529 (43%), Gaps = 50/529 (9%)
Query: 27 ELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQVEEHE 86
EL Q+D K+ E + T K+RE + + L+ +++G Q+++ E
Sbjct: 478 ELQHQLD---KTKQQHQEQQALQQSTTAKLREAQ-----NDLEQVLRQIGDKDQKIQNLE 529
Query: 87 KIKQEMTMEYKQELKKLHEEL-----------CILKRSYEKLQ--KKQMREFRGNTKNHR 133
+ Q+ + E L+K E+L +L + EK ++Q+ + KN
Sbjct: 530 ALLQK-SKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQS 588
Query: 134 EDRSEI-ERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRK 192
E + E L +++E + + + L + V+ L +Q E+ + Q+ +
Sbjct: 589 ESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKT 648
Query: 193 QKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKE 252
+ L S E + ++ L + L+ A + + + E+ ++T +++ + + Q E
Sbjct: 649 ELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLE 708
Query: 253 EKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEK-LQ--EKVKATNTQHAVEAI 309
L+E ++ +L+++ EL+ ++ E E + KE+ LQ ++ + NT + A
Sbjct: 709 SHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRAT 768
Query: 310 RPREESLAEKKYTSQGQGDLDSVLSQLNFTHTSEDLLQAEVTCLEGSLESVSATCKQLSQ 369
++ EK+ S + DL L + ++ ++T E + + + LSQ
Sbjct: 769 ELSKQLEMEKEIVSSTRLDLQKKSEAL-------ESIKQKLTKQEEEKQILKQDFETLSQ 821
Query: 370 ELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHLTQELHQRDI 429
E ++EEL NN + + +L Q E + E+S + +L +
Sbjct: 822 ETKIQHEEL------NNRIQTTVTEL--------QKVKMEKEALMTELSTVKDKLSKVSD 867
Query: 430 TIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILD-QLESLKLENRHLSEMVMKLELGLH 488
++ ++K ++ +A + E E K L Q+E+ E + L + + K + H
Sbjct: 868 SLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASH 927
Query: 489 EAKEISLADLQENYIEALNKLVSENQQLQKDLMNTKSQLEISTQMCKKQ 537
+ K + L +QE I+A N L +N++ ++ L ++L+ S++ KKQ
Sbjct: 928 QLK-LELNSMQEQLIQAQNTL-KQNEKEEQQLQGNINELKQSSEQKKKQ 974
Score = 73.9 bits (180), Expect = 5e-13
Identities = 115/554 (20%), Positives = 228/554 (41%), Gaps = 73/554 (13%)
Query: 162 IYQQQVSSLEAQRKALAEQSEIIQAQLVN------RKQKLESVELSSQSEIQHLSSKLER 215
+ +Q+V L+A K SE ++ +L ++ K + + S +E+Q L +LE
Sbjct: 87 LLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQLEE 146
Query: 216 ANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESE-----KLLEALQEEK- 269
A T N +++ L + + T + ++ + +E LRE+ +L E L +E
Sbjct: 147 AQ-TENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEAT 205
Query: 270 --RELKAALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAIRPREESLAEKKYTSQGQG 327
++LK L + + A ++KE +Q + N +E R E+ E K
Sbjct: 206 VIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNM--TLERERESEKLKDECKK------ 257
Query: 328 DLDSVLSQLNFTHTSEDLLQAEVTCLEGSLESVSATCKQLSQELMEKYEELKRMEAHNNE 387
LQ++ E ++ + + + QE+ +EL+++++ NE
Sbjct: 258 ------------------LQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNE 299
Query: 388 YKAEIKKLKEQILQGEQSYSSALEGMKMEI---SHLTQELHQRDITIASTKGSSSDMEKR 444
+ + L E +L+ EQ Y+ E E ++ LHQ+D+ + S E
Sbjct: 300 LTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETS 359
Query: 445 LRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMVMKLELGLHEAKEISLADLQENYIE 504
L + +K +++ ++L ++ + +HL +L+ E ++ L LQ +
Sbjct: 360 LHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGL-QLQSEINQ 418
Query: 505 ALNKLVSENQQLQKDLMNTKSQLEISTQ--MCKKQNDRIFKPTHSRTTE-FKNTEFKPTH 561
+KL+ +QL + K Q ++S++ M K+Q + SR E K T
Sbjct: 419 LHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTE 478
Query: 562 GQHRHDGIKTEHYKTDL--HSPRGQASDSINPMSRVLSPLSPQISPCSSTRSLTSYSLCK 619
QH+ D K +H + S + ++ N + +VL + + K
Sbjct: 479 LQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQ--------------K 524
Query: 620 THSLPSALDTNEANFSDTMSESMNDQEEFISSCSLPVSPLGSIATRFLEEEELRSHHILE 679
+L + L ++ N S E +E+ + G T L + + ++H + E
Sbjct: 525 IQNLEALLQKSKENISLLEKE----REDLYAKIQA-----GEGETAVLNQLQEKNHTLQE 575
Query: 680 RLDAHIEELKRESE 693
++ E+LK +SE
Sbjct: 576 QVTQLTEKLKNQSE 589
Score = 64.3 bits (155), Expect = 4e-10
Identities = 74/417 (17%), Positives = 180/417 (43%), Gaps = 49/417 (11%)
Query: 39 KKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQ 98
++ + +G + L+ + +++++++L+ +L + + Q+ E K++Q++T + Q
Sbjct: 953 EEQQLQGNINELKQSSEQKKKQIEALQGELKIA------VLQKTELENKLQQQLT-QAAQ 1005
Query: 99 ELKKLHEELCILKRSYEKLQK--KQMR-EFRGNTKNHREDRSEIERLTAKIEEFRQKSLD 155
EL E++ +L+ +YEK Q+ KQ++ +F G R +++ + K+ ++ +
Sbjct: 1006 ELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLIS 1065
Query: 156 WEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESVELSS---QSEIQHLSSK 212
Q + + L+ + L + S + QL R + L+ ++ + E+ + SK
Sbjct: 1066 NRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSK 1125
Query: 213 LERANDTICANELEIERLT-----------MRVNDLVGTSMTVLQEQQQK---------- 251
L + C E EI +L + +L ++Q++ +
Sbjct: 1126 LAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAA 1185
Query: 252 -EEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAIR 310
E++ R + L + +++E+ ELK +E +H +KE +K + + ++
Sbjct: 1186 VEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITA 1245
Query: 311 PREESLAEKKYTSQGQGDLDSVLSQLNFTHTSEDLLQAEVTCLEGSLESVSATCKQLSQE 370
E KK Q + + Q D L+ E+ LE ++++ + L +
Sbjct: 1246 LNENLGTVKKEWQSSQRRVSELEKQ-------TDDLRGEIAVLEATVQNNQDERRALLER 1298
Query: 371 LMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHLTQELHQR 427
++ E+++++ E + ++ + + E ++I H TQ L+++
Sbjct: 1299 CLKGEGEIEKLQTKVLELQRKLDNTTAAVQE------LGRENQSLQIKH-TQALNRK 1348
>gi|109659847 filamin A interacting protein 1-like isoform 3 [Homo
sapiens]
Length = 1133
Score = 99.8 bits (247), Expect = 8e-21
Identities = 100/437 (22%), Positives = 204/437 (46%), Gaps = 44/437 (10%)
Query: 147 EEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESVELSSQSEI 206
+ F+ KS W++ IY++ ++ L+ + E I QL+ ++ L + E
Sbjct: 122 DAFQAKSTPWQED--IYEKPMNELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEK 179
Query: 207 QHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQ 266
+ +E++++ IC E E ERL ++ QE + +EEK +E EK + L+
Sbjct: 180 RKHKEYMEKSDEFICLLEQECERLKKLID----------QEIKSQEEKEQEKEKRVTTLK 229
Query: 267 EEKRELKA----ALQSQENLIHEARIQKEKLQE---KVKATNTQHAVEAIRPREE----S 315
EE +LK+ + Q+ L + +Q++K+QE K T+T+ A+ R +EE +
Sbjct: 230 EELTKLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKAT 289
Query: 316 LAEKK---YTSQGQGDLDSVLSQLNFTHTSEDLLQAEVTCLE---GSLESVSATCKQLSQ 369
EK+ T++ D D+++++L + LQ ++ L LE + + ++ +
Sbjct: 290 RLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEE 349
Query: 370 ELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHLTQELHQRDI 429
EL + E++ + E N AE+++L++++L E ++ M+ + L + L + +
Sbjct: 350 ELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIK-MEEQCRDLNKRLERETL 408
Query: 430 TIASTKGSSSDMEKRLRAEMQKAEDKAVEHKE----ILDQLESLKLENRHLSEMVMKLEL 485
K + KR+ A ++K ED + K+ + LE ++ + LS+ + L++
Sbjct: 409 QSKDFKLEVEKLSKRIMA-LEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKV 467
Query: 486 GLH--EAKEISLADLQENYIEALNKL-------VSENQQLQKDLMNTKSQLEISTQMCKK 536
+ EA E L + E L KL V E + + + L T+ +L+ ++ +
Sbjct: 468 RIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQV 527
Query: 537 QNDRIFKPTHSRTTEFK 553
+ +++ T E K
Sbjct: 528 EQNKVTTVTEKLIEETK 544
Score = 83.6 bits (205), Expect = 6e-16
Identities = 117/564 (20%), Positives = 247/564 (43%), Gaps = 69/564 (12%)
Query: 18 LTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGM 77
+T+ + EL +L K +MV ++ L L ++ Q+++ L + TH ++ +
Sbjct: 225 VTTLKEELTKL-KSFALMVVDEQQR-------LTAQLTLQRQKIQELTTNAKETHTKLAL 276
Query: 78 LHQQVEEHEKIKQEMTMEYKQELKKLHEE---------------------LCILKRSYEK 116
+V+E E+ + E + + K H++ L L R ++
Sbjct: 277 AEARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDE 336
Query: 117 LQK--KQMREFRGNTKNHREDRSEIER----LTAKIEEFRQKSLDWE---KQRLIYQQQV 167
L++ + +R+ ++ +E S+ E + A++EE R++ LD E ++ + ++Q
Sbjct: 337 LEETNRSLRKAEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQC 396
Query: 168 SSLEA--QRKALAEQSEIIQAQLVNRK----QKLESVELSSQSEIQHLSSKLERANDTIC 221
L +R+ L + ++ + ++++ +KLE S+ E L LE+ T
Sbjct: 397 RDLNKRLERETLQSKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTK 456
Query: 222 ANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQEN 281
E+E L +R+ +L + + + +E L + + L +E++ + L+ E+
Sbjct: 457 QLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTED 516
Query: 282 LIHEARIQKEKLQEKVKATNTQHAVEAIRPREES---LAEKKYTSQGQGDLDSVLSQLNF 338
+ A Q + Q KV T T+ +E + +S + EK Y+ + D + ++L
Sbjct: 517 KLQAASSQLQVEQNKV-TTVTEKLIEETKRALKSKTDVEEKMYSV--TKERDDLKNKLKA 573
Query: 339 THTSEDLLQAEVTCLEGSLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQ 398
+ L + V L+ L+S+ A K + + + H K IK+L ++
Sbjct: 574 EEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQENNK--IKELSQE 631
Query: 399 I--LQGEQSYSSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRL-RAEMQKAEDK 455
+ L+ + A+E M+ + L +R A+ + + + K L +M+ A+ K
Sbjct: 632 VERLKLKLKDMKAIEDDLMKTEDEYETLERR---YANERDKAQFLSKELEHVKMELAKYK 688
Query: 456 AVEHKE------ILDQLESLKLENRHLSEMVMKLELGLHE--AKEISLADLQENYI---E 504
E E + +L+ + ++ HLS V L+ +HE A E + LQ ++ +
Sbjct: 689 LAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMATEDLICHLQGDHSVLQK 748
Query: 505 ALNKLVSENQQLQKDLMNTKSQLE 528
LN+ + N+ L +++ N +LE
Sbjct: 749 KLNQQENRNRDLGREIENLTKELE 772
Score = 82.0 bits (201), Expect = 2e-15
Identities = 114/554 (20%), Positives = 238/554 (42%), Gaps = 82/554 (14%)
Query: 60 ELKSLRSQLDVTHKEVGMLHQQVEEH--------------EKIKQEMTMEYKQE------ 99
+ KS Q D+ K + L + VE+H EK +++ +E ++E
Sbjct: 125 QAKSTPWQEDIYEKPMNELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKRKHKE 184
Query: 100 -LKKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDRSEIERL---TAKIEEFRQKSLD 155
++K E +C+L++ E+L+K +E + + +E + L K++ F +D
Sbjct: 185 YMEKSDEFICLLEQECERLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVD 244
Query: 156 WEKQRL-----IYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESVELSSQSEIQHLS 210
E+QRL + +Q++ L K + + +A++ +QK +E E+Q +
Sbjct: 245 -EQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLE----KELQTQT 299
Query: 211 SKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEE-- 268
+K + DTI A + ++ + + E ++ LR++E+ L+ ++E+
Sbjct: 300 TKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKIS 359
Query: 269 KREL-KAALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAIRPREESLAEKKYTSQGQG 327
K E A + ++ + + + E E++ Q R E+L K + + +
Sbjct: 360 KGEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVE- 418
Query: 328 DLDSVLSQLNFTHTSEDLLQAEVTCLEGSLESVSATCKQLSQELMEKYEELKRMEAHNNE 387
L + L + + + E L+ +LE T KQLSQEL +K +EA +
Sbjct: 419 KLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESR 478
Query: 388 -------YKAEIKKLK--------------EQILQGE---QSYSSALEGMKMEISHLTQE 423
K ++ KLK E++ + E Q+ SS L+ + +++ +T++
Sbjct: 479 LEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEK 538
Query: 424 LHQR-----------DITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLK-- 470
L + + + S D++ +L+AE +K D + ++L+SL+
Sbjct: 539 LIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAI 598
Query: 471 ----LENRHLSEMVMKLELGLHEAKEISLADLQENYIEALNKLVSENQQLQKDLMNTKSQ 526
L+N+ L++ K LH+ + +L + +E L + + + ++ DLM T+ +
Sbjct: 599 EKDFLKNK-LNQDSGKSTTALHQENN-KIKELSQE-VERLKLKLKDMKAIEDDLMKTEDE 655
Query: 527 LEISTQMCKKQNDR 540
E + + D+
Sbjct: 656 YETLERRYANERDK 669
>gi|109659845 filamin A interacting protein 1-like isoform 1 [Homo
sapiens]
Length = 1135
Score = 99.8 bits (247), Expect = 8e-21
Identities = 100/437 (22%), Positives = 204/437 (46%), Gaps = 44/437 (10%)
Query: 147 EEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESVELSSQSEI 206
+ F+ KS W++ IY++ ++ L+ + E I QL+ ++ L + E
Sbjct: 122 DAFQAKSTPWQED--IYEKPMNELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEK 179
Query: 207 QHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQ 266
+ +E++++ IC E E ERL ++ QE + +EEK +E EK + L+
Sbjct: 180 RKHKEYMEKSDEFICLLEQECERLKKLID----------QEIKSQEEKEQEKEKRVTTLK 229
Query: 267 EEKRELKA----ALQSQENLIHEARIQKEKLQE---KVKATNTQHAVEAIRPREE----S 315
EE +LK+ + Q+ L + +Q++K+QE K T+T+ A+ R +EE +
Sbjct: 230 EELTKLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKAT 289
Query: 316 LAEKK---YTSQGQGDLDSVLSQLNFTHTSEDLLQAEVTCLE---GSLESVSATCKQLSQ 369
EK+ T++ D D+++++L + LQ ++ L LE + + ++ +
Sbjct: 290 RLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEE 349
Query: 370 ELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHLTQELHQRDI 429
EL + E++ + E N AE+++L++++L E ++ M+ + L + L + +
Sbjct: 350 ELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIK-MEEQCRDLNKRLERETL 408
Query: 430 TIASTKGSSSDMEKRLRAEMQKAEDKAVEHKE----ILDQLESLKLENRHLSEMVMKLEL 485
K + KR+ A ++K ED + K+ + LE ++ + LS+ + L++
Sbjct: 409 QSKDFKLEVEKLSKRIMA-LEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKV 467
Query: 486 GLH--EAKEISLADLQENYIEALNKL-------VSENQQLQKDLMNTKSQLEISTQMCKK 536
+ EA E L + E L KL V E + + + L T+ +L+ ++ +
Sbjct: 468 RIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQV 527
Query: 537 QNDRIFKPTHSRTTEFK 553
+ +++ T E K
Sbjct: 528 EQNKVTTVTEKLIEETK 544
Score = 83.6 bits (205), Expect = 6e-16
Identities = 117/564 (20%), Positives = 247/564 (43%), Gaps = 69/564 (12%)
Query: 18 LTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGM 77
+T+ + EL +L K +MV ++ L L ++ Q+++ L + TH ++ +
Sbjct: 225 VTTLKEELTKL-KSFALMVVDEQQR-------LTAQLTLQRQKIQELTTNAKETHTKLAL 276
Query: 78 LHQQVEEHEKIKQEMTMEYKQELKKLHEE---------------------LCILKRSYEK 116
+V+E E+ + E + + K H++ L L R ++
Sbjct: 277 AEARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDE 336
Query: 117 LQK--KQMREFRGNTKNHREDRSEIER----LTAKIEEFRQKSLDWE---KQRLIYQQQV 167
L++ + +R+ ++ +E S+ E + A++EE R++ LD E ++ + ++Q
Sbjct: 337 LEETNRSLRKAEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQC 396
Query: 168 SSLEA--QRKALAEQSEIIQAQLVNRK----QKLESVELSSQSEIQHLSSKLERANDTIC 221
L +R+ L + ++ + ++++ +KLE S+ E L LE+ T
Sbjct: 397 RDLNKRLERETLQSKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTK 456
Query: 222 ANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQEN 281
E+E L +R+ +L + + + +E L + + L +E++ + L+ E+
Sbjct: 457 QLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTED 516
Query: 282 LIHEARIQKEKLQEKVKATNTQHAVEAIRPREES---LAEKKYTSQGQGDLDSVLSQLNF 338
+ A Q + Q KV T T+ +E + +S + EK Y+ + D + ++L
Sbjct: 517 KLQAASSQLQVEQNKV-TTVTEKLIEETKRALKSKTDVEEKMYSV--TKERDDLKNKLKA 573
Query: 339 THTSEDLLQAEVTCLEGSLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQ 398
+ L + V L+ L+S+ A K + + + H K IK+L ++
Sbjct: 574 EEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQENNK--IKELSQE 631
Query: 399 I--LQGEQSYSSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRL-RAEMQKAEDK 455
+ L+ + A+E M+ + L +R A+ + + + K L +M+ A+ K
Sbjct: 632 VERLKLKLKDMKAIEDDLMKTEDEYETLERR---YANERDKAQFLSKELEHVKMELAKYK 688
Query: 456 AVEHKE------ILDQLESLKLENRHLSEMVMKLELGLHE--AKEISLADLQENYI---E 504
E E + +L+ + ++ HLS V L+ +HE A E + LQ ++ +
Sbjct: 689 LAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMATEDLICHLQGDHSVLQK 748
Query: 505 ALNKLVSENQQLQKDLMNTKSQLE 528
LN+ + N+ L +++ N +LE
Sbjct: 749 KLNQQENRNRDLGREIENLTKELE 772
Score = 82.0 bits (201), Expect = 2e-15
Identities = 114/554 (20%), Positives = 238/554 (42%), Gaps = 82/554 (14%)
Query: 60 ELKSLRSQLDVTHKEVGMLHQQVEEH--------------EKIKQEMTMEYKQE------ 99
+ KS Q D+ K + L + VE+H EK +++ +E ++E
Sbjct: 125 QAKSTPWQEDIYEKPMNELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKRKHKE 184
Query: 100 -LKKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDRSEIERL---TAKIEEFRQKSLD 155
++K E +C+L++ E+L+K +E + + +E + L K++ F +D
Sbjct: 185 YMEKSDEFICLLEQECERLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVD 244
Query: 156 WEKQRL-----IYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESVELSSQSEIQHLS 210
E+QRL + +Q++ L K + + +A++ +QK +E E+Q +
Sbjct: 245 -EQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLE----KELQTQT 299
Query: 211 SKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEE-- 268
+K + DTI A + ++ + + E ++ LR++E+ L+ ++E+
Sbjct: 300 TKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKIS 359
Query: 269 KREL-KAALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAIRPREESLAEKKYTSQGQG 327
K E A + ++ + + + E E++ Q R E+L K + + +
Sbjct: 360 KGEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVE- 418
Query: 328 DLDSVLSQLNFTHTSEDLLQAEVTCLEGSLESVSATCKQLSQELMEKYEELKRMEAHNNE 387
L + L + + + E L+ +LE T KQLSQEL +K +EA +
Sbjct: 419 KLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESR 478
Query: 388 -------YKAEIKKLK--------------EQILQGE---QSYSSALEGMKMEISHLTQE 423
K ++ KLK E++ + E Q+ SS L+ + +++ +T++
Sbjct: 479 LEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEK 538
Query: 424 LHQR-----------DITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLK-- 470
L + + + S D++ +L+AE +K D + ++L+SL+
Sbjct: 539 LIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAI 598
Query: 471 ----LENRHLSEMVMKLELGLHEAKEISLADLQENYIEALNKLVSENQQLQKDLMNTKSQ 526
L+N+ L++ K LH+ + +L + +E L + + + ++ DLM T+ +
Sbjct: 599 EKDFLKNK-LNQDSGKSTTALHQENN-KIKELSQE-VERLKLKLKDMKAIEDDLMKTEDE 655
Query: 527 LEISTQMCKKQNDR 540
E + + D+
Sbjct: 656 YETLERRYANERDK 669
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 99.4 bits (246), Expect = 1e-20
Identities = 155/740 (20%), Positives = 305/740 (41%), Gaps = 125/740 (16%)
Query: 24 ELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQVE 83
ELQ+L +Q+ +KS+WEG+ ++LE+ L + + SL+S+L E+ + Q E
Sbjct: 1286 ELQDLQRQLS-QNQEEKSKWEGKQNSLESELMELHETMASLQSRL--RRAELQRMEAQGE 1342
Query: 84 EH--EKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDRSEIER 141
+ K+ +T + + H + +++ + + E + R RS ++
Sbjct: 1343 RELLQAAKENLTAQVE------HLQAAVVEARAQASAAGILEE------DLRTARSALKL 1390
Query: 142 LTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESVELS 201
++E R+++ Q L Q+Q AQ KAL E ++ L R++++E++
Sbjct: 1391 KNEEVESERERA-----QAL--QEQGELKVAQGKALQENLALLTQTLAEREEEVETL--- 1440
Query: 202 SQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLR----- 256
+ +IQ L + E + L++++ V+ + QEQ Q+ EK R
Sbjct: 1441 -RGQIQELEKQREMQKAALELLSLDLKKRNQEVD--------LQQEQIQELEKCRSVLEH 1491
Query: 257 ------ESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAIR 310
E E+ L +E+ REL+ ++Q N++ ++ EK + +E+ R
Sbjct: 1492 LPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQ---------MIESQR 1542
Query: 311 PREESLAEKKYTSQGQGDLDSVLSQLNFTHTSEDLLQAEVTCLEGSLESVSATCKQLSQE 370
+ + L ++ T L+ + +L H + Q + LEG E+ L+ +
Sbjct: 1543 GQVQDLKKQLVT------LECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLD 1596
Query: 371 LMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSS---ALEGMKMEISHLTQELHQR 427
L E+ +EL+ + ++ ++ L ++ + +Q S +E ++ + HLTQ+L +R
Sbjct: 1597 LEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERR 1656
Query: 428 DITI---------------ASTKGSSSDME----------KRLRAEMQKAEDKAVE---- 458
D + TK D+E + L + Q +++A E
Sbjct: 1657 DQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGP 1716
Query: 459 HKEILDQLESLKLENRHLSEMVMKLELGLHEAKEISLADLQENYIEALNK-------LVS 511
K LE +KL R + V + +HE +E L D E ++ L++ L+S
Sbjct: 1717 SKAQRGSLEHMKLILRDKEKEVECQQEHIHELQE--LKDQLEQQLQGLHRKVGETSLLLS 1774
Query: 512 ENQQ----LQKDLMNTKSQLEISTQMCKKQNDRIFKPTHSRTTEFKNTEFKPTHGQHRHD 567
+ +Q LQ+ L + Q E+ Q + Q D + R E + + + Q + +
Sbjct: 1775 QREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEE 1834
Query: 568 GIKTEHYKTD-LHSPRGQASDSINPMSRVLSPLSPQISPCSSTRSLTSYSLCKTHSLPSA 626
+K K D L QA ++ L Q ++
Sbjct: 1835 RVKE---KADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEG----------RR 1881
Query: 627 LDTNEANFSDTMSESMNDQEEFIS---SCSLPVSPLGSIATRFLEEEELRSHHILERLDA 683
+ E D +ES ++ ++ C+ + TR L++ L++ +L+ D
Sbjct: 1882 VQALEEVLGDLRAESREQEKALLALQQQCAEQAQE-HEVETRALQDSWLQAQAVLKERDQ 1940
Query: 684 HIEELKRESEKTVRQFTALK 703
+E L+ ES+ + Q A +
Sbjct: 1941 ELEALRAESQSSRHQEEAAR 1960
Score = 96.3 bits (238), Expect = 9e-20
Identities = 119/532 (22%), Positives = 236/532 (44%), Gaps = 45/532 (8%)
Query: 31 QIDIMVAHKKSE--WEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQVEEHEKI 88
Q+D+ A K+ E WE TH LE L+ E+ L++ L +E + +++ E
Sbjct: 644 QVDLAEAEKRREALWEKNTH-LEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQ 702
Query: 89 KQEMTMEYKQ---ELKKLHEELCILKRSYEKL-QKKQMREFRGNT-KNHREDRSEIERLT 143
++ T + +Q E K+ E L + E L ++K E R + R+D +E +
Sbjct: 703 QEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGL 762
Query: 144 AKIEEFRQKSL-DWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESVELSS 202
+ +E + SL + ++Q + + LE Q + + + E+IQ ++ K +L++ +
Sbjct: 763 SSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQA 822
Query: 203 QSEIQHLSSKLERAN-DTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESE-- 259
+ E + +L +A + A E + VN L +E+ +KE + E
Sbjct: 823 EQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQL--------REKWEKERSWHQQELA 874
Query: 260 KLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAIRPREESLAEK 319
K LE+L+ EK EL+ L+ Q+ + + Q+E+ + + ++ Q +E + R L
Sbjct: 875 KALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETL 934
Query: 320 KYTSQGQGDLDSVLSQLNFTHTSEDLLQAEVTCLE----------------------GSL 357
T + D L +L + L + E T + +L
Sbjct: 935 LQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAAL 994
Query: 358 ESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEI 417
+ S++ Q +L ++ E+LK ++ + +++ ++ L+ Q Y+ + ++ E
Sbjct: 995 QEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREK 1054
Query: 418 SHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLS 477
+ LT L +++ + + + S ++ L A Q ++ E KE+ Q+E L+ E +
Sbjct: 1055 ASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKE 1114
Query: 478 EMVMKLELGLHEAKEISLADLQENYIEA-LNKLVSENQQLQKDLMNTKSQLE 528
+ E L E E+ + + E + A L ++ QLQ L +T+SQLE
Sbjct: 1115 ADFLAQEAQLLE--ELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLE 1164
Score = 84.7 bits (208), Expect = 3e-16
Identities = 128/604 (21%), Positives = 261/604 (43%), Gaps = 76/604 (12%)
Query: 18 LTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGM 77
L C+ + L +Q D +WE AL L+ E +L Q EV
Sbjct: 409 LAGCQEAVNLLQQQHD--------QWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDS 460
Query: 78 LHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDRS 137
L ++ E +K ++E+ +Q+L+ L +E L+R +LQ Q +G + +E+
Sbjct: 461 LSKERELLQKAREEL----RQQLEVLEQEAWRLRRVNVELQL-QGDSAQGQKEEQQEELH 515
Query: 138 ----EIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQ 193
E ERL + K + + + ++ + S + + L ++ + A L +Q
Sbjct: 516 LAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALARAEQ 575
Query: 194 ---KLESVELSSQSEIQHLSS---KLERANDTICANELEIERLTMRVNDLVGTSMTVLQE 247
+L S E + ++E+ L + KL N+ + +++ + + +++ + + + ++
Sbjct: 576 SIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEA 635
Query: 248 QQQKEEKLR----ESEKLLEALQEEKRELKAALQSQENLIHEAR-----IQKEKLQEKVK 298
+Q L+ E+EK EAL E+ L+A LQ E E + IQ+EK + + K
Sbjct: 636 AEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKK 695
Query: 299 ATNTQHAVEAIRPR-----EESLAEKKYTSQGQGDLDSVLSQLNFTHTSEDLLQAEVTCL 353
+ ++H EA + +E+ +++ ++ + ++++ + ++ + L
Sbjct: 696 LSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDL 755
Query: 354 EGSLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKE--QILQGEQSYSSALE 411
L+ +S+ + L L E ++ +E + + +I+ + + +++QGE +
Sbjct: 756 AEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGE------VR 809
Query: 412 GMKMEI-SHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKA--------------EDKA 456
+K+E+ + +Q +RD A+ + + ++ E + E QKA ++++
Sbjct: 810 CLKLELDTERSQAEQERD--AAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERS 867
Query: 457 VEHKEILDQLESLKLENRHLSEMVMKLELGLHEA-----------KEISLADLQENYIEA 505
+E+ LESL+ E L EM +K + EA E +L +Q +
Sbjct: 868 WHQQELAKALESLEREKMEL-EMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKE 926
Query: 506 LNKLVSENQQLQKDLMNTKSQLEISTQMCKKQNDRIFKPTHSRTTEFKNT--EFKPTHGQ 563
L+ Q QK+L + QLE Q K Q + + T T+ + E K Q
Sbjct: 927 RVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQ 986
Query: 564 HRHD 567
HR D
Sbjct: 987 HRDD 990
Score = 79.3 bits (194), Expect = 1e-14
Identities = 158/744 (21%), Positives = 293/744 (39%), Gaps = 110/744 (14%)
Query: 50 LETCLKIREQELKSLRSQLDVTHKEV----GMLHQQVEEHEKIKQEMTMEYKQELKKLHE 105
L ++ REQ+L R Q+ K+ +L Q+ E EK K +M + +++ L +
Sbjct: 1492 LPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEK-KDQMIESQRGQVQDLKK 1550
Query: 106 EL----CI---LKRSYEKL--QKKQMREFRGNTKNHR----------EDRS-EIERLTAK 145
+L C+ L+ ++ K+ Q+K ++E G + R E+RS E++ +++
Sbjct: 1551 QLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQ 1610
Query: 146 IEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESVELSSQSE 205
I + S ++ Q+V S Q + L Q E + L R Q+L + +
Sbjct: 1611 IHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQEL----MLQKER 1666
Query: 206 IQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEK----------- 254
IQ L + R I +LE +L++R T+ L +++ +E K
Sbjct: 1667 IQVLEDQRTRQTK-ILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLE 1725
Query: 255 -----LRESEKLLEALQE---EKRELKAALQSQENLIHE-----ARIQKEKLQE-KVKAT 300
LR+ EK +E QE E +ELK L+ Q +H + + ++ QE V
Sbjct: 1726 HMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQ 1785
Query: 301 NTQHAVEAIRPREESLAEK-----KYTSQGQGDLDSVLSQLNFTHTSEDLLQAEVTCLEG 355
Q A E +E+SL + + +Q +L+++ + E+ ++ + L+G
Sbjct: 1786 QLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQG 1845
Query: 356 SLESVSATCKQLSQELMEKYEELKRME---------------------AHNNEYKAEIKK 394
+LE T K+ EL + E+ +R+E A + E + +
Sbjct: 1846 ALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLA 1905
Query: 395 LKEQILQGEQSY---SSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQK 451
L++Q + Q + + AL+ ++ + +E Q + + SS E+ RA +
Sbjct: 1906 LQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEA 1965
Query: 452 AEDKAVEHKEILDQLESLKLENRHLSEMV------MKLELGLHEAKEISLAD---LQENY 502
++ + L E LE LS + ++ L +A L + +QE
Sbjct: 1966 LQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGE 2025
Query: 503 IEALNKLVSEN-QQLQKDLMNTKSQLE--------ISTQMCKKQNDRIFKPTHSRTTEFK 553
I+ + E+ QQLQ+ L +L + + ++ + + + + E +
Sbjct: 2026 IQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQERE 2085
Query: 554 NTEFKPTHGQHRHDGI---KTEHYKTDLHSPRGQASDSINPMSRVLSPLSPQISPCSSTR 610
E + H R + + E +L + + + P S SP+ Q S
Sbjct: 2086 EEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSLE 2145
Query: 611 SLTSYSLCKTHSLPSALDTNEANFSDTMSESMNDQEEFISSCSLPVSPLGSIATRFLEEE 670
L L +AL EA + E D ++ VS L +A FL+
Sbjct: 2146 PRLQREL---ERLQAALRQTEAREIE-WREKAQDLALSLAQTKASVSSLQEVA-MFLQAS 2200
Query: 671 ELRSHHILERLDAHIEELKRESEK 694
L +RL +E +R EK
Sbjct: 2201 VLERDSEQQRLQDELELTRRALEK 2224
Score = 72.4 bits (176), Expect = 1e-12
Identities = 117/529 (22%), Positives = 225/529 (42%), Gaps = 68/529 (12%)
Query: 46 RTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQVEEHEKI---KQEMTMEYKQELKK 102
+T LE R QEL L+SQ D+ E L +V E + Q+ +Y++ +K
Sbjct: 252 KTQELEKEAHERSQELIQLKSQGDLEKAE---LQDRVTELSALLTQSQKQNEDYEKMIKA 308
Query: 103 LHEELCILKRSYEKLQKKQMREFRGNTKNHREDRSEIERLTAKIEEF------------- 149
L E + IL+ ++ +L M ++N +E++ ++++ I +
Sbjct: 309 LRETVEILETNHTEL----MEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSG 364
Query: 150 RQKSLDWEK---QRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESVELSSQ--- 203
+ SL+ + + YQ +L R L + + +Q E+V L Q
Sbjct: 365 HENSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHD 424
Query: 204 ---SEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEK 260
E + L +L++ E + L + DL G ++ +E++ ++ E +
Sbjct: 425 QWEEEGKALRQRLQKLTG-------ERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQ 477
Query: 261 LLEALQEEK---RELKAALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAIRPREESLA 317
LE L++E R + LQ Q + A+ QKE+ QE++ E R +E +
Sbjct: 478 QLEVLEQEAWRLRRVNVELQLQGD---SAQGQKEEQQEELHLA----VRERERLQEMLMG 530
Query: 318 EKKYTSQGQGDLDSVLSQLNFTHTSEDLL---QAEVTC----LEGSLESVSATCKQLSQE 370
+ S+ +L ++ L +H +LL Q EVT E S+ +S++ L E
Sbjct: 531 LEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTE 590
Query: 371 LMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHLTQELHQRDIT 430
+ + ++ A N + L +Q+LQ E+ S +ME + + Q D+
Sbjct: 591 VADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCS--RMEAAEQARNALQVDLA 648
Query: 431 IASTKGSSS-DMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMVMKLELGLHE 489
A + + + L A++QKAE+ E + L ++ K E+ KL H+
Sbjct: 649 EAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEK------EEIQKKLSESRHQ 702
Query: 490 AKEISLADLQENYIEA--LNKLVSENQQLQKDLMNTKSQLEISTQMCKK 536
+E + L++ + EA ++++ Q ++ L+ K+ LE+ Q ++
Sbjct: 703 -QEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVER 750
Score = 56.6 bits (135), Expect = 8e-08
Identities = 122/601 (20%), Positives = 231/601 (38%), Gaps = 74/601 (12%)
Query: 42 EWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELK 101
E E R L+ IR+QEL +LR + E L Q+E + +E ++ +
Sbjct: 1063 EKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEA 1122
Query: 102 KLHEELCILKRSYEKLQKK---QMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEK 158
+L EEL + ++L+ Q + R S++E L A+ + Q +
Sbjct: 1123 QLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQL 1182
Query: 159 QRLI--YQQQVSSLEAQRKALA------------EQSEIIQAQLVNRKQKLESVELSSQS 204
L QQ + S+ R L+ E + L R L ++ + +
Sbjct: 1183 ASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVA 1242
Query: 205 EIQH-LSSKLERANDTICANELEIERLTMRVNDL------VGTSMTVLQEQ-QQKEEKLR 256
H L L + T ++++L R+ D V T + LQ Q Q +E+
Sbjct: 1243 SALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKS 1302
Query: 257 ESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAIRPREESL 316
+ E +L+ E EL + S ++ + A +Q+ + Q + + Q A E + + E L
Sbjct: 1303 KWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELL--QAAKENLTAQVEHL 1360
Query: 317 AEKKYTSQGQGDLDSVLSQ----------LNFTHTSEDLLQAEVTCLEGSLESVSATCKQ 366
++ Q +L + L + +A+ +G L+ Q
Sbjct: 1361 QAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQ 1420
Query: 367 -----LSQELMEKYEE-------LKRMEAHNNEYKAEIK------KLKEQILQGEQSYSS 408
L+Q L E+ EE ++ +E KA ++ K + Q + +Q
Sbjct: 1421 ENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQ 1480
Query: 409 ALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLES 468
LE + + HL + +R+ + + ++EK + E + +E ++ +ES
Sbjct: 1481 ELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIES 1540
Query: 469 LKLENRHLSEMVMKLELGLHEAKEISLADLQENY--IEALNKLVSE----NQQLQKDLMN 522
+ + + L + ++ L E +L+EN+ +E KL+ E + + L +
Sbjct: 1541 QRGQVQDLKKQLVTL--------ECLALELEENHHKMECQQKLIKELEGQRETQRVALTH 1592
Query: 523 TKSQLEISTQMCKKQNDRIFK-PTHS----RTTEFKNTEFKPTHGQHRHDGIKTEHYKTD 577
LE +Q + Q+ +I +HS R + ++ E K Q + EH D
Sbjct: 1593 LTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQD 1652
Query: 578 L 578
L
Sbjct: 1653 L 1653
Score = 45.4 bits (106), Expect = 2e-04
Identities = 86/461 (18%), Positives = 190/461 (41%), Gaps = 76/461 (16%)
Query: 16 GFLTSCEAELQELMKQIDIMVAHKKSEWEGRTHALE-------TCLKIREQELKSLRSQL 68
G L + E ++ + + A + E E T AL+ LK R+QEL++LR++
Sbjct: 1890 GDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAES 1949
Query: 69 DVT-HKE-------------VGMLH---QQVEEHEKIKQEMTMEYKQELKKLHEELCILK 111
+ H+E +G H Q E+H + E++ + L L +
Sbjct: 1950 QSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQ 2009
Query: 112 ---RSYEKLQKKQMREFRGNTKNHREDRSEIER-LTAKIEEFR----------------- 150
R E+ + Q E + ++ED ++++ L + EE R
Sbjct: 2010 AHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRV 2069
Query: 151 QKSLDWEKQRLIYQQQVSSLEAQRKALAE--------QSEIIQAQLVNRKQKLESVELSS 202
Q+++ EKQ L +++ + +++ E + EI++ + ++ LE++ S
Sbjct: 2070 QENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHSH 2129
Query: 203 Q-SEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKL 261
+ S ++ S KL+ + + E+ERL + + ++ Q L +++
Sbjct: 2130 KTSPMEEQSLKLDSLEPRL---QRELERLQAALRQTEAREIEWREKAQDLALSLAQTKAS 2186
Query: 262 LEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAIR-PREESLAEKK 320
+ +LQE L+A++ +++ ++++LQ++++ T E + P S AE
Sbjct: 2187 VSSLQEVAMFLQASVLERDS-------EQQRLQDELELTRRALEKERLHSPGATSTAELG 2239
Query: 321 YTSQGQGDLDSVLSQLNFTHTSEDLLQAEVTCLEGSLESVSATCKQLSQELMEKYEELKR 380
+ L V ++AE + +S + L Q + + R
Sbjct: 2240 SRGEQGVQLGEVSG-----------VEAEPSPDGMEKQSWRQRLEHLQQAVARLEIDRSR 2288
Query: 381 MEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHLT 421
++ HN + ++ +++++ + + ++ A + +EIS T
Sbjct: 2289 LQRHNVQLRSTLEQVERERRKLKREAMRAAQAGSLEISKAT 2329
Score = 44.3 bits (103), Expect = 4e-04
Identities = 94/411 (22%), Positives = 164/411 (39%), Gaps = 65/411 (15%)
Query: 157 EKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERA 216
E+Q L QQQ++ +A + S+ Q + +KL++ L +S Q L +LE
Sbjct: 21 EEQVLALQQQMAENQAASWRKLKNSQEAQQRQATLVRKLQAKVLQYRSWCQELEKRLEAT 80
Query: 217 NDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAAL 276
I +E + + L+E+QQ+ E L E L E+ + AL
Sbjct: 81 GGPIPQRWENVEEPNL------DELLVRLEEEQQRCESLAEVNTQLRLHMEKADVVNKAL 134
Query: 277 QSQENLIHEARIQKEKLQEKVKATNTQHAVEAIRPREESLAEKKYTSQGQGDLDSVLSQL 336
R EKL V+ R R+E + ++ SQ Q + + L
Sbjct: 135 ----------REDVEKL-----------TVDWSRARDELMRKE---SQWQMEQEFFKGYL 170
Query: 337 NFTH-TSEDLLQAEVTCLEGSLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKL 395
H L + VT LE SAT ++LME E R+ + +L
Sbjct: 171 KGEHGRLLSLWREVVTFRRHFLEMKSAT----DRDLMELKAEHVRL---SGSLLTCCLRL 223
Query: 396 KEQILQGEQSYSSALEG--------MKMEISHLTQELHQRDITIASTKGSSSDMEKRLRA 447
E + S ++G + + L +E H+R + K S D+EK A
Sbjct: 224 TVGAQSREPNGSGRMDGREPAQLLLLLAKTQELEKEAHERSQELIQLK-SQGDLEK---A 279
Query: 448 EMQKAEDKAVEHKEILDQLESLKLENRHLSEMVMKLELGLHEAKEISLADLQENYIEALN 507
E+Q D+ E L +L +++ +E K+ L E EI L+ N+ E +
Sbjct: 280 ELQ---DRVTE-------LSALLTQSQKQNEDYEKMIKALRETVEI----LETNHTELME 325
Query: 508 KLVSENQQLQKDLMNTKSQLEISTQMCKKQNDRIFKPT-HSRTTEFKNTEF 557
S ++ Q++ ++ + ++ TQ+ ++ D I + + H + E ++ F
Sbjct: 326 HEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGHENSLELDSSIF 376
Score = 37.0 bits (84), Expect = 0.063
Identities = 98/482 (20%), Positives = 183/482 (37%), Gaps = 69/482 (14%)
Query: 103 LHEELCILKRSYEKLQKKQMREFRGNTKNHREDRSEIERLTAKIEEFR------QKSLD- 155
L E++ L++ + Q R+ + + + + + + +L AK+ ++R +K L+
Sbjct: 20 LEEQVLALQQQMAENQAASWRKLKNSQEAQQRQATLVRKLQAKVLQYRSWCQELEKRLEA 79
Query: 156 --------WEK-QRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESVELSSQSEI 206
WE + + + LE +++ +E + QL +K + V + + ++
Sbjct: 80 TGGPIPQRWENVEEPNLDELLVRLEEEQQRCESLAE-VNTQLRLHMEKADVVNKALREDV 138
Query: 207 QHLSSKLERANDTICANE-----------------------LEIERLTMRVNDLVGTSMT 243
+ L+ RA D + E L E +T R + L S T
Sbjct: 139 EKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLLSLWREVVTFRRHFLEMKSAT 198
Query: 244 VLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATNTQ 303
+ K E +R S LL L QS+E +E Q + TQ
Sbjct: 199 DRDLMELKAEHVRLSGSLLTCC----LRLTVGAQSREPNGSGRMDGREPAQLLLLLAKTQ 254
Query: 304 HAVEAIRPREESLAEKKYTSQGQGDLDSVLSQLNFTHTSEDLLQAEV--TCLEGSLESVS 361
+ R + L + K QGDL+ Q T S L Q++ E ++++
Sbjct: 255 ELEKEAHERSQELIQLK----SQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALR 310
Query: 362 ATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQ-----GEQSYSSALEGMKME 416
T + L E E + + E K ++++ + I Q G+ + +E
Sbjct: 311 ETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGHENSLE 370
Query: 417 I-SHLTQELHQRDITIASTKGSSSDMEKR-----LRAEMQKAEDKAVEHKEILDQLESLK 470
+ S + + +D A T S +R LR ++ ++ ++ DQ E
Sbjct: 371 LDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEE-- 428
Query: 471 LENRHLSEMVMKLELGLHEAKEISLADLQENYIEALNKLVSENQQLQKDLMNTKSQLEIS 530
E + L + + KL G + DLQ +++L+K E + LQK + QLE+
Sbjct: 429 -EGKALRQRLQKL-TGERDTLAGQTVDLQ-GEVDSLSK---ERELLQKAREELRQQLEVL 482
Query: 531 TQ 532
Q
Sbjct: 483 EQ 484
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 98.2 bits (243), Expect = 2e-20
Identities = 130/577 (22%), Positives = 248/577 (42%), Gaps = 74/577 (12%)
Query: 25 LQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRS-QLDVTHKEVGMLHQQVE 83
L+EL +Q++ K+ E LET K E+K L+ + + HK + Q E
Sbjct: 1205 LEELSEQLE-QAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQE 1263
Query: 84 EHEKIKQ--EMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFR--GNTKNHREDRSEI 139
H K+ + + +E ++ KL EL + E+ +KK ++ + + ++ +D E+
Sbjct: 1264 LHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQEL 1323
Query: 140 ERLTAKIEEFRQK--------SLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNR 191
+ EE RQK L+ EK L Q+Q E RK L +Q +Q+QL +
Sbjct: 1324 LQ-----EETRQKLNLSSRIRQLEEEKNSL--QEQQEEEEEARKNLEKQVLALQSQLADT 1376
Query: 192 KQK-------LESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTV 244
K+K +ES+E + + ++ + +R + A + ++E+ R+ +
Sbjct: 1377 KKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYD-KLEKTKNRLQQELDDLTVD 1435
Query: 245 LQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATNTQH 304
L Q+Q L + +K + L E++ + A + + R + E +++ KA +
Sbjct: 1436 LDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERD-----RAEAEAREKETKALSLAR 1490
Query: 305 AVE-AIRPREESLAEKKYTSQGQGDLDSVLSQLNFTHTSEDLLQAEVTCLEGSLESVSAT 363
A+E A+ +EE + K Q + D++ ++S + + L+ LE +E +
Sbjct: 1491 ALEEALEAKEEFERQNK---QLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQ 1547
Query: 364 CKQLSQELMEKYEELKRMEAHNNEYKAEIKK-LKEQILQGEQSYSSALEGMKMEISHLTQ 422
++L EL + R+E + KA+ ++ L+ + Q E+ ++ ++ + L
Sbjct: 1548 LEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELED 1607
Query: 423 ELHQRDITIASTKGSSSDMEKRLRAEMQ---KAEDKAVEH-------------------- 459
E QR + +AS K D+ K L A+++ KA D+ ++
Sbjct: 1608 ERKQRALAVASKKKMEIDL-KDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARA 1666
Query: 460 ---------KEILDQLESLKLENRHLSEMVMKLELGLHEAKEI--SLADLQENYIEALNK 508
KE +L+SL+ E L E + E A++ LAD N +
Sbjct: 1667 SRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSA 1726
Query: 509 LVSENQQLQKDLMNTKSQLEISTQMCKKQNDRIFKPT 545
L+ E ++L+ + + +LE + NDR K T
Sbjct: 1727 LLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTT 1763
Score = 92.4 bits (228), Expect = 1e-18
Identities = 116/533 (21%), Positives = 224/533 (42%), Gaps = 76/533 (14%)
Query: 22 EAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQ 81
E EL +++ +A KK E E H LE+ ++ E+ + L+++ + L +Q
Sbjct: 899 ETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQ 958
Query: 82 VEEHEKIKQEMTMEY---KQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDRSE 138
++E E +Q++ +E + ++KK+ EE+ +L+ K K+ K EDR
Sbjct: 959 LDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKE---------KKLMEDR-- 1007
Query: 139 IERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESV 198
I ++++ E +K+ + K R + +S LE + K + E + +L K+KL+
Sbjct: 1008 IAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLK----KEEKTRQELEKAKRKLDGE 1063
Query: 199 ELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRES 258
Q +I L ++++ + E E++ R +D L+ ++ + ++ E
Sbjct: 1064 TTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAE- 1122
Query: 259 EKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAIRPREESLAE 318
L E + EK A + + +L E K +L++ + T Q + RE+ +AE
Sbjct: 1123 --LQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRT--KREQEVAE 1178
Query: 319 KKYTSQGQGDLDSVLSQLNFTHTSEDLLQAEVTCLEGSLESVSATCKQLSQELMEKYEEL 378
K + + N +D+ Q T LE EL E+ E+
Sbjct: 1179 LKKALEEETK--------NHEAQIQDMRQRHATALE---------------ELSEQLEQA 1215
Query: 379 KRMEAHNNEYKAEIKKLKEQILQGEQSYS---SALEGMKMEISH-------LTQELHQR- 427
KR +KA ++K K+ + + + L+ +K E H QELH +
Sbjct: 1216 KR-------FKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKV 1268
Query: 428 ------DITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMVM 481
+ +A + + +++AE K ++ + LES + + L +
Sbjct: 1269 SEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEET 1328
Query: 482 KLELGLH------EAKEISLADLQENYIEALNKLVSENQQLQKDLMNTKSQLE 528
+ +L L E ++ SL + QE EA L + LQ L +TK +++
Sbjct: 1329 RQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVD 1381
Score = 89.7 bits (221), Expect = 8e-18
Identities = 121/543 (22%), Positives = 231/543 (42%), Gaps = 65/543 (11%)
Query: 58 EQELKSLRSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKL 117
+QEL++ R Q K+ L ++ + HE Q+M + L++L E+L KR L
Sbjct: 1165 QQELRTKREQEVAELKKA--LEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANL 1222
Query: 118 QKKQMREFRGNTKNHREDRSEIERLT-AKIE-EFRQKSLDWEKQRLIYQQQVSSLEAQRK 175
+K + +G +++E E++ L K E E ++K LD + Q L +VS + R
Sbjct: 1223 EKNK----QGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQEL--HAKVSEGDRLRV 1276
Query: 176 ALAEQSEIIQAQLVNRKQKLESVE---LSSQSEIQHLSSKLERANDTICANELEIERLTM 232
LAE++ +Q +L N LE E + + L S+L+ + + + L+
Sbjct: 1277 ELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSS 1336
Query: 233 RVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEK 292
R+ L ++ ++Q+++EE + EK + ALQ + + K + I K+K
Sbjct: 1337 RIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKK 1396
Query: 293 LQEKVKATNTQHAVEAIRPREESLAEKKYTSQGQ-----GDLD---SVLSQLNFTHTSED 344
L + +A + + +A+ + L + K Q + DLD V S L D
Sbjct: 1397 LLKDAEALSQRLEEKAL--AYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFD 1454
Query: 345 LLQAEVTCL-----------EGSLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIK 393
L AE + E L++ L E E + E N + +A+++
Sbjct: 1455 QLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADME 1514
Query: 394 KL---KEQILQGEQSYSSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQ 450
L K+ + + + ++ ++ + +L + + + +T+ + +LR E+
Sbjct: 1515 DLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATE------DAKLRLEVN 1568
Query: 451 KAEDKAVEHKEILDQLESLKLENRHLSEMVMKLELGLHEAK-------------EISLAD 497
KA +++ + E + + R L + V +LE L + + EI L D
Sbjct: 1569 MQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKD 1628
Query: 498 LQENYIEALNK----LVSENQQLQKDLMNTKSQLEISTQMCKKQNDRIFKPTHSRTTEFK 553
L E IEA NK ++ + ++LQ + + + +LE + D IF + + K
Sbjct: 1629 L-EAQIEAANKARDEVIKQLRKLQAQMKDYQRELE----EARASRDEIFAQSKESEKKLK 1683
Query: 554 NTE 556
+ E
Sbjct: 1684 SLE 1686
Score = 80.9 bits (198), Expect = 4e-15
Identities = 107/464 (23%), Positives = 200/464 (43%), Gaps = 59/464 (12%)
Query: 23 AELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQV 82
A++++LM K + H LE + EQ+++ +R+QL+ E+
Sbjct: 1511 ADMEDLMSS--------KDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAK 1562
Query: 83 EEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDRSEIERL 142
E Q M +++++L+ E+ ++L KQ+RE ++ R+ R+ +
Sbjct: 1563 LRLEVNMQAMKAQFERDLQTRDEQ----NEEKKRLLIKQVRELEAELEDERKQRA-LAVA 1617
Query: 143 TAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESVELSS 202
+ K E K L+ Q+ + R + +Q +QAQ+ + +++LE +S
Sbjct: 1618 SKKKMEIDLKDLE---------AQIEAANKARDEVIKQLRKLQAQMKDYQRELEEAR-AS 1667
Query: 203 QSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLL 262
+ EI S + E+ ++ E EI +L + QE+ + +++ S
Sbjct: 1668 RDEIFAQSKESEKKLKSL---EAEILQLQEELASSERARRHAEQERDELADEITNSASGK 1724
Query: 263 EALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATNTQ-HAVEAIRPREESLAEKKY 321
AL +EKR L+A + E + E + E L ++ + T Q + A E S A+K
Sbjct: 1725 SALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKS- 1783
Query: 322 TSQGQGDLDSVLSQLNFTHTSEDLLQAEVTCLEGSLES-----VSATCKQLSQELMEKYE 376
D+ QL + L+A++ LEG+++S +SA ++ Q + +
Sbjct: 1784 --------DNARQQLERQNKE---LKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQ 1832
Query: 377 ELKRMEAHNNEYKAEIKKLKEQILQGE------QSYSSALEGMKMEISHLTQELHQRDIT 430
E K A N + KKLKE +Q E Y +E + L ++L + +
Sbjct: 1833 EAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAE-- 1890
Query: 431 IASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENR 474
+T+ ++S R ++Q+ D A E E L + E L+NR
Sbjct: 1891 EEATRANAS------RRKLQRELDDATEANEGLSR-EVSTLKNR 1927
Score = 75.1 bits (183), Expect = 2e-13
Identities = 101/517 (19%), Positives = 227/517 (43%), Gaps = 59/517 (11%)
Query: 20 SCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQ---ELKSLRSQLD---VTHK 73
S A E + + K+++ ALE L+ +E+ + K LR+ ++ +
Sbjct: 1462 SISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKD 1521
Query: 74 EVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHR 133
+VG ++E+ ++ ++ E + +L++L +EL + + +L+ N +
Sbjct: 1522 DVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEV-----------NMQ 1570
Query: 134 EDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQ 193
+++ ER +E + EK+RL+ +Q V LEA+ + +Q +A V K+
Sbjct: 1571 AMKAQFERDLQTRDEQNE-----EKKRLLIKQ-VRELEAELEDERKQ----RALAVASKK 1620
Query: 194 KLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEE 253
K+E +++ L +++E AN ++ +L ++ D + +
Sbjct: 1621 KMEI-------DLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFA 1673
Query: 254 KLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKV--KATNTQHAVEAIRP 311
+ +ESEK L++L+ E +L+ L S E A ++++L +++ A+ ++ R
Sbjct: 1674 QSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRR 1733
Query: 312 REESLAE-KKYTSQGQGDLDSVLSQLNFTHTSEDLLQAEVTCLEGSLESVSATCKQLSQE 370
E +A+ ++ + Q +++ + + T D L AE+ E S S +Q
Sbjct: 1734 LEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAA-ERSAAQKSDNARQ---- 1788
Query: 371 LMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHLTQELHQRDIT 430
++E N E KA++++L+ + + + + + ++ +I L ++L Q
Sbjct: 1789 ---------QLERQNKELKAKLQELEGAV---KSKFKATISALEAKIGQLEEQLEQEAKE 1836
Query: 431 IASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMVMKLELGLHEA 490
A+ EK+L+ + ED+ + +Q+E N + ++ +LE EA
Sbjct: 1837 RAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEK---ANARMKQLKRQLEEAEEEA 1893
Query: 491 KEISLADLQENYIEALNKLVSENQQLQKDLMNTKSQL 527
+ + + L+ N+ L +++ K++L
Sbjct: 1894 TRANAS--RRKLQRELDDATEANEGLSREVSTLKNRL 1928
Score = 63.5 bits (153), Expect = 6e-10
Identities = 87/410 (21%), Positives = 168/410 (40%), Gaps = 25/410 (6%)
Query: 164 QQQVSSLEAQRKALAEQSEIIQAQL--VNRKQKLESVELSSQSEIQHLSSKLERANDTIC 221
QQQ+S+L+ ++ A ++ Q V K K + E+Q +L + +
Sbjct: 810 QQQLSALKVLQRNCAAYLKLRHWQWWRVFTKVKPLLQVTRQEEELQAKDEELLKVKEKQT 869
Query: 222 ANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQEN 281
E E+E + + L+ + ++ Q + E E+E++ L +K+EL+ L E+
Sbjct: 870 KVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLES 929
Query: 282 LIHEARIQKEKLQEKVKATNTQHAVEAIRPREESLAEKKYTSQGQGDLDSVLSQLNFTHT 341
+ E + + LQ + K I+ EE L E++ Q + L+ V ++
Sbjct: 930 RVEEEEERNQILQNEKKKMQAH-----IQDLEEQLDEEEGARQ-KLQLEKVTAEAKIKKM 983
Query: 342 SEDLLQAEVTCLEGSLES--VSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQI 399
E++L E + E + + S +L E+ E+ K + N+ + I L+E++
Sbjct: 984 EEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERL 1043
Query: 400 LQGE---QSYSSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKA 456
+ E Q A + E + L ++ + I K + E+ L+ + + +D+
Sbjct: 1044 KKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDET 1103
Query: 457 VEHKEILDQLESLKLENRHLSEMVMKLELGLHEAKEISLADLQENYIEALNKLVSENQQL 516
+ L + L+ + L E + E E DL E +EAL +L
Sbjct: 1104 LHKNNALKVVRELQAQIAELQE-DFESEKASRNKAEKQKRDLSEE-LEAL------KTEL 1155
Query: 517 QKDLMNTKSQLEISTQMCKKQNDRIFKPTHSRTTEFKNTEFKPTHGQHRH 566
+ L T +Q E+ T K+ + + + E KN E + + RH
Sbjct: 1156 EDTLDTTAAQQELRT----KREQEVAELKKALEEETKNHEAQIQDMRQRH 1201
Score = 60.1 bits (144), Expect = 7e-09
Identities = 102/475 (21%), Positives = 194/475 (40%), Gaps = 84/475 (17%)
Query: 244 VLQEQQQKEEKLRESEKLLEALQEEKR---ELKAALQSQENLIHEARIQKEKLQEKVKAT 300
+LQ +Q+EE + E+LL+ +++ + EL+ + + L+ E I E+LQ +
Sbjct: 844 LLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAE---- 899
Query: 301 NTQHAVEAIRPREESLAEKKYTSQGQGDLDSVLSQLNFTHTSEDLLQAEVTCLEGSLESV 360
T+ EA R A+K+ + DL+S + + E+ Q L+ + +
Sbjct: 900 -TELFAEAEEMRARLAAKKQELEEILHDLESRVEE------EEERNQI----LQNEKKKM 948
Query: 361 SATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKM----- 415
A + L ++L E+ ++++ +A+IKK++E+IL E S ++ K+
Sbjct: 949 QAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRI 1008
Query: 416 -EISHLTQELHQRDITIASTKGSS----SDMEKRL------RAEMQKAEDKAV-EHKEIL 463
E S E ++ +A + SD+E+RL R E++KA+ K E ++
Sbjct: 1009 AECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQ 1068
Query: 464 DQLESLKLENRHLSEMVMKLELGLHEAKEISLADL--QENYIEALNKLVSENQQLQKDLM 521
DQ+ L+ + L + K E L A + + N ++ + +L ++ +LQ+D
Sbjct: 1069 DQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFE 1128
Query: 522 NTKSQLEISTQMCKKQNDRIFKPTHSRTTEFKNT--------EFKPTHGQHRHDGIKTEH 573
+ K+ S +KQ + + + TE ++T E + Q + K
Sbjct: 1129 SEKA----SRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALE 1184
Query: 574 YKTDLHSPRGQASDSINPMSRVLSPLSPQISPCSSTRSLTSYSLCKTHSLPSALDTNEAN 633
+T H Q D + L LS Q+ + AN
Sbjct: 1185 EETKNHE--AQIQDMRQRHATALEELSEQLEQAKRFK---------------------AN 1221
Query: 634 FSDTMSESMNDQEEFISSCSLPVSPLGSIATRFLEEEELRSHHILERLDAHIEEL 688
D +E +C + V L++ + S H ++LDA ++EL
Sbjct: 1222 LEKNKQGLETDNKEL--ACEVKV----------LQQVKAESEHKRKKLDAQVQEL 1264
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 97.8 bits (242), Expect = 3e-20
Identities = 128/544 (23%), Positives = 240/544 (44%), Gaps = 53/544 (9%)
Query: 22 EAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQ 81
E EL +++ + KK E E H LE ++ E+ + L+++ + + L +Q
Sbjct: 892 ETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQ 951
Query: 82 VEEHEKIKQEMTMEY---KQELKKLHEELCILKRSYEKLQKKQ------MREFRGNTKNH 132
+EE E +Q++ +E + +LKKL EE IL+ KL K++ + EF N
Sbjct: 952 LEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEE 1011
Query: 133 REDRSEIERLTAK----IEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQL 188
E + +L K I + ++ EKQR ++ LE L++Q +QAQ+
Sbjct: 1012 EEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQI 1071
Query: 189 VNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQ 248
K +L E Q+ + + + + N + +I L ++++L + +
Sbjct: 1072 AELKMQLAKKEEELQAALARVEEEAAQKNMAL----KKIRELESQISELQEDLESERASR 1127
Query: 249 QQKEEKLRESEKLLEALQEEKRELKAALQSQENL----IHEARIQKEKLQEKVKATNTQH 304
+ E++ R+ + LEAL+ E + + +Q+ L E I K+ L+E+ K Q
Sbjct: 1128 NKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQ- 1186
Query: 305 AVEAIRPRE----ESLAEK-KYTSQGQGDLDSVLSQLNFTHTSEDLLQAEVTCL---EGS 356
++ +R + E LAE+ + T + + +L+ L L EV L +G
Sbjct: 1187 -IQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTL---ENERGELANEVKVLLQGKGD 1242
Query: 357 LESVSATCKQLSQELMEKYEELKRMEAH----NNEYKAEIKKLKEQILQGEQSYS----- 407
E + QEL K+ E +R+ + + E+ + + Q + S
Sbjct: 1243 SEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKD 1302
Query: 408 -SALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQL 466
SALE + L QE +++ +++ STK + EK E + E++A + E Q+
Sbjct: 1303 FSALESQLQDTQELLQEENRQKLSL-STKLKQVEDEKNSFREQLEEEEEAKHNLE--KQI 1359
Query: 467 ESLKLENRHLSEMVMKLE--LGLHEAKEISLADLQENYIEALNKLVSENQQLQKDLMNTK 524
+L + +++M K+E +G E E LQ++ +E L++ E L TK
Sbjct: 1360 ATL---HAQVADMKKKMEDSVGCLETAEEVKRKLQKD-LEGLSQRHEEKVAAYDKLEKTK 1415
Query: 525 SQLE 528
++L+
Sbjct: 1416 TRLQ 1419
Score = 73.2 bits (178), Expect = 8e-13
Identities = 105/570 (18%), Positives = 247/570 (43%), Gaps = 38/570 (6%)
Query: 152 KSLDWEKQRLIYQQ----QVSSLEAQRKALAEQS-EIIQAQLV--NRKQKLESVELSSQS 204
K +W+ RL + QVS E + A E+ ++ + QL NR ++E+++ +
Sbjct: 821 KLRNWQWWRLFTKVKPLLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMA 880
Query: 205 EIQHLSSKLERANDTICANELEIE-RLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLE 263
E L +L+ A +CA E+ RLT + +L + +++EE+ + + +
Sbjct: 881 EKLQLQEQLQ-AETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKK 939
Query: 264 ALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAIRPREESLAEKKYTS 323
+Q+ +EL+ L+ +E+ + +++K + K+K + + + + LA++K
Sbjct: 940 KMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQII--LEDQNCKLAKEKKL- 996
Query: 324 QGQGDLDSVLSQLNFTHTSEDLLQAEVTCLEGSLESVSATCKQLSQELMEKYEEL----K 379
L+ +++ T E+ + L+ E++ ++ + ++ +EL +
Sbjct: 997 -----LEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRR 1051
Query: 380 RMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHLTQELHQRDIT---IASTKG 436
++E + + +I +L+ QI + + + E ++ ++ + +E Q+++ I +
Sbjct: 1052 KLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELES 1111
Query: 437 SSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLE-NRHLSEMVMKLELGLHEAKEISL 495
S++++ L +E + +++ ++LE+LK E L + EL +E+++
Sbjct: 1112 QISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNI 1171
Query: 496 ADLQENYIEALNKLVSENQQLQKDLMNTKSQLEISTQMCKKQNDRIFKPTHSRTTEFKNT 555
L++ E ++ Q++++ +L + K+ + K +T E +
Sbjct: 1172 --LKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKA--KQTLENERG 1227
Query: 556 EFKPTHGQHRHDGIKTEHYKTDLHSPRGQASDSINPMSRVLSPLSPQIS----PCSSTRS 611
E +EH + + + + N RV + L+ +++ +
Sbjct: 1228 ELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTG 1287
Query: 612 LTSYSLCKTHSLPSALDTNEANFSDT--MSESMNDQEEFISSCSLPVSPLGSIATRFLEE 669
L S S K+ L E+ DT + + N Q+ +S+ V + LEE
Sbjct: 1288 LLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEE 1347
Query: 670 EELRSHHI---LERLDAHIEELKRESEKTV 696
EE H++ + L A + ++K++ E +V
Sbjct: 1348 EEEAKHNLEKQIATLHAQVADMKKKMEDSV 1377
Score = 70.5 bits (171), Expect = 5e-12
Identities = 97/455 (21%), Positives = 182/455 (40%), Gaps = 93/455 (20%)
Query: 22 EAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQ 81
E + ++L++Q+ M A + E + R+ A+ K+ E +LK L + +D +K
Sbjct: 1581 EEKKKQLVRQVREMEAELEDERKQRSMAVAARKKL-EMDLKDLEAHIDSANKN------- 1632
Query: 82 VEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDRSEIER 141
E IKQ L+KL ++ K MRE + R+ E
Sbjct: 1633 --RDEAIKQ---------LRKLQAQM-----------KDCMRELD-------DTRASREE 1663
Query: 142 LTAKIEEFRQKSLDWEKQRLIYQQQVSSLE-AQRKALAEQSEIIQ---------AQLVNR 191
+ A+ +E +K E + + Q+++++ E A+R+A E+ E+ A +
Sbjct: 1664 ILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEE 1723
Query: 192 KQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQK 251
K++LE+ + E++ E ND + L+I D + T + + + QK
Sbjct: 1724 KRRLEARIAQLEEELEEEQGNTELINDRLKKANLQI--------DQINTDLNLERSHAQK 1775
Query: 252 EEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATNTQHAV---EA 308
E R+ L+ + +ELK LQ E + K K + + A + A +
Sbjct: 1776 NENARQQ------LERQNKELKVKLQEMEGTV------KSKYKASITALEAKIAQLEEQL 1823
Query: 309 IRPREESLAEKKYTSQGQGDLDSVLSQLNFTHTSEDLLQAEVTCLEGSLESVSATCKQLS 368
+E A K + + L VL Q++ + + + + + S KQL
Sbjct: 1824 DNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQA-------DKASTRLKQLK 1876
Query: 369 QELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHLTQELHQRD 428
++L E EE +R A + + E++ E + M E+S L +L + D
Sbjct: 1877 RQLEEAEEEAQRANASRRKLQRELEDATE-----------TADAMNREVSSLKNKLRRGD 1925
Query: 429 ITIA-----STKGSSSDMEKRLRAEMQKAEDKAVE 458
+ + KG+ ++ + + AE K E
Sbjct: 1926 LPFVVPRRMARKGAGDGSDEEVDGKADGAEAKPAE 1960
Score = 66.2 bits (160), Expect = 1e-10
Identities = 108/558 (19%), Positives = 239/558 (42%), Gaps = 78/558 (13%)
Query: 16 GFLTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEV 75
G L + E ++L K ++ + + + E LE +QEL L LD +
Sbjct: 1378 GCLETAEEVKRKLQKDLEGL-SQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSA 1436
Query: 76 GMLHQQVEEHEKIKQE---MTMEYKQELKKLHEE--------LCILKRSYEKLQKKQMRE 124
L ++ ++ +++ E ++ +Y +E + E L + + E +++K E
Sbjct: 1437 CNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELE 1496
Query: 125 FRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALA------ 178
+ +++ R+E+E L + ++ + + EK + +QQV ++ Q + L
Sbjct: 1497 -----RLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQAT 1551
Query: 179 --------------------------EQSEIIQAQLVNRKQKLE----------SVELSS 202
EQSE + QLV + +++E S+ +++
Sbjct: 1552 EDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAA 1611
Query: 203 QSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKL----RES 258
+ +++ LE D+ N E + ++ + M L + + E++ +E+
Sbjct: 1612 RKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKEN 1671
Query: 259 EKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATNTQH--AVEAIRPREESL 316
EK L++++ E +L+ L + E +A+ ++++L +++ ++ + A+E R E +
Sbjct: 1672 EKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARI 1731
Query: 317 AE-KKYTSQGQGDLDSVLSQLNFTHTSEDLLQAEVTCLEGSLESVSATCKQLSQELMEKY 375
A+ ++ + QG+ + + +L + D + ++ + +QL ++ E
Sbjct: 1732 AQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELK 1791
Query: 376 EELKRMEAH-NNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHLTQ-ELHQRDITIAS 433
+L+ ME ++YKA I L+ +I Q E+ + + + + + E +D+ +
Sbjct: 1792 VKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLL-- 1849
Query: 434 TKGSSSDMEKRLRAEMQKAEDKA-VEHKEILDQLESLKLENRHLSEMVMKLELGLHEAKE 492
D E+R + + DKA K++ QLE + E + + KL+ L +A E
Sbjct: 1850 ----QVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATE 1905
Query: 493 ISLADLQENYIEAL-NKL 509
AD + +L NKL
Sbjct: 1906 --TADAMNREVSSLKNKL 1921
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 97.8 bits (242), Expect = 3e-20
Identities = 128/583 (21%), Positives = 242/583 (41%), Gaps = 97/583 (16%)
Query: 22 EAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQ--ELKS-----------LRSQL 68
E E EL +ID M ++ ++ + +++ TC + +Q E+K+ L Q
Sbjct: 1222 EKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQK 1281
Query: 69 DVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGN 128
+ G L +VEE E + ++T KQ L + EEL K+QM E
Sbjct: 1282 ARLQTQNGELSHRVEEKESLISQLTKS-KQALTQQLEEL-----------KRQMEE---- 1325
Query: 129 TKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQ-QVSSLEAQRKALAEQSEIIQ-- 185
E + A + D + R Y++ Q + E QR SE+ Q
Sbjct: 1326 ---------ETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWR 1376
Query: 186 ----AQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVG-- 239
+ R ++LE + +Q E AN + E +RL V DL+
Sbjct: 1377 TKYETDAIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDL 1436
Query: 240 ----TSMTVLQEQQQK--------EEKLRESEKLLEALQEEKRELKAALQSQENLIHEA- 286
T+ L ++Q+ ++KL ES+ LEA Q+E R L L N E
Sbjct: 1437 ERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVV 1496
Query: 287 ------RIQKEKLQEKVKATNTQHAVEAIRPREESLAEKKYTSQGQGDLDSVLSQL--NF 338
R + + LQE++ T+ E + +E+ KK Q + DL L ++ +
Sbjct: 1497 DQLETLRRENKNLQEEISDL-TEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSL 1555
Query: 339 THTSEDLLQAEVTCLEGSLESVSATCKQLSQELMEKYEELKRM--------EAHNNEYKA 390
H +L+ ++ +S +L ++++EK EE++++ EA + A
Sbjct: 1556 EHEESKILRVQL--------ELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDA 1607
Query: 391 EIKKLKEQILQGEQSYSSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQ 450
EI+ + L+ ++ L M++++ H +++ + + + +G D + L
Sbjct: 1608 EIRS-RNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHL----- 1661
Query: 451 KAEDKAVEHKEILDQLESLKLENRHLSEMVMKLELGLHEAKEISLADLQENYIEALNKLV 510
+D ++++ +QL ++ N L E + ++++ L + + QE ++A +++
Sbjct: 1662 --DDALRSNEDLKEQLAIVERRNGLLLEELEEMKVALEQTERTRRLSEQE-LLDASDRVQ 1718
Query: 511 SENQQLQKDLMNTKSQLEISTQMCKKQNDRIFKPTHSRTTEFK 553
+ Q L+NTK +LE C+ + + + SR E K
Sbjct: 1719 LLHSQ-NTSLINTKKKLEADIAQCQAEVENSIQ--ESRNAEEK 1758
Score = 80.5 bits (197), Expect = 5e-15
Identities = 137/721 (19%), Positives = 281/721 (38%), Gaps = 107/721 (14%)
Query: 22 EAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQ 81
E + +L ++++ ++ + E G T A K RE E + +R L+ +
Sbjct: 1137 EKQRSDLARELE-EISERLEEASGATSAQIEMNKKREAEFQKMRRDLE----------EA 1185
Query: 82 VEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDRSEIER 141
+HE + + + +L E++ L+R +KL+K++ E + EI+
Sbjct: 1186 TLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEK-----------SELKMEIDD 1234
Query: 142 LTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESVELS 201
+ + IE + + E+ + Q S ++A+ + +Q+++I L +K +L
Sbjct: 1235 MASNIEALSKSKSNIERTCRTVEDQFSEIKAKDE---QQTQLIH-DLNMQKARL------ 1284
Query: 202 SQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKL 261
Q++ LS ++E I + LT ++ +L ++Q EE+ + +
Sbjct: 1285 -QTQNGELSHRVEEKESLISQLTKSKQALTQQLEEL----------KRQMEEETKAKNAM 1333
Query: 262 LEALQEEKRE---LKAALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAIRPREESLAE 318
ALQ + + L+ + ++ E + K +V T++ +AI+ EE
Sbjct: 1334 AHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEA 1393
Query: 319 KKYTSQ----GQGDLDSVLSQLNFTHTSEDLLQAEVTCLEGSLESVSATCKQLSQE---- 370
KK +Q + + ++ S+ ++ LQ EV L LE C L ++
Sbjct: 1394 KKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRNF 1453
Query: 371 ---LMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSA---LEGMKMEISHLTQEL 424
L E ++L +A + E + L ++ + +Y LE ++ E +L +E+
Sbjct: 1454 DKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEI 1513
Query: 425 HQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMVMKLE 484
IA T + + EK + Q+ D V +E+ LE H +++++
Sbjct: 1514 SDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLE-------HEESKILRVQ 1566
Query: 485 LGLHEA----------KEISLADLQEN---YIEALNKLVSENQQLQKDLMNTKSQL---- 527
L L + K+ + L+ N EAL ++ + + D + K ++
Sbjct: 1567 LELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKMEGDL 1626
Query: 528 -EISTQMCKKQNDRIFKPTHSRTT--EFKNTEFKPTHGQHRHDGIKTEHYKTDLHSPRGQ 584
E+ Q+ H RT + K+++ H D +++ DL
Sbjct: 1627 NEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQL------HLDDALRSNE---DLKEQLAI 1677
Query: 585 ASDSINPMSRVLSPLSPQISPCSSTRSLTSYSLCKT-------HSLPSALDTNEANFSDT 637
+ L + + TR L+ L HS ++L +
Sbjct: 1678 VERRNGLLLEELEEMKVALEQTERTRRLSEQELLDASDRVQLLHSQNTSLINTKKKLEAD 1737
Query: 638 MSESMNDQEEFI-SSCSLPVSPLGSIATRFLEEEELRSHHILERLDAHIEELKRESEKTV 696
+++ + E I S + +I + EEL+ + AH+E +K+ E+TV
Sbjct: 1738 IAQCQAEVENSIQESRNAEEKAKKAITDAAMMAEELKKE---QDTSAHLERMKKNLEQTV 1794
Query: 697 R 697
+
Sbjct: 1795 K 1795
Score = 76.6 bits (187), Expect = 7e-14
Identities = 128/674 (18%), Positives = 270/674 (40%), Gaps = 69/674 (10%)
Query: 83 EEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFR----------GNTKNH 132
E+ E+ K+E+ + K+L E++ L + LQ + E G K+
Sbjct: 858 EDFERTKEELARSEARR-KELEEKMVSLLQEKNDLQLQVQSETENLMDAEERCEGLIKSK 916
Query: 133 REDRSEIERLTAKIEEFRQ-------KSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQ 185
++++ LT ++EE + K + E + ++ + LE + ++ +
Sbjct: 917 ILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTLTKVEKEKHATE 976
Query: 186 AQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVL 245
++ N +++ ++E + + S E T+ ++L++E +VN L+ + +
Sbjct: 977 NKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTL--DDLQVEE--DKVNGLIKINAKLE 1032
Query: 246 QEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATN---T 302
Q+ E L + +KL L+ KR+L+ L+ + I + K++++EK+K +
Sbjct: 1033 QQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELS 1092
Query: 303 QHAVEAIRPREESLAEKKYTSQGQGDLDSVLSQLNFTHTSEDLLQAEVTCLEGSLESVSA 362
Q + + SL +K + Q ++ + ++ HT ++ + + L LE +S
Sbjct: 1093 QLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISE 1152
Query: 363 TCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQ-------------------GE 403
++ S + E K+ EA E++ + L+E LQ GE
Sbjct: 1153 RLEEASGATSAQIEMNKKREA---EFQKMRRDLEEATLQHEATAATLRKKQADSVAELGE 1209
Query: 404 Q--SYSSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLR-AEMQKAEDKAVEHK 460
Q + + ++ E S L E+ I + S S++E+ R E Q +E KA + +
Sbjct: 1210 QIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQ 1269
Query: 461 ------EILDQLESLKLENRHLSEMVMKLELGLHEAKEISLADLQENYIEALNKLVSENQ 514
++ Q L+ +N LS V + E + + + A Q+ +E L + + E
Sbjct: 1270 QTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQ--LEELKRQMEEET 1327
Query: 515 QLQKDLMNTKSQLEISTQMCKKQ--NDRIFKPTHSRTTEFKNTEFKPTHGQHRHDGI--- 569
+ + + + + ++Q ++ K R N+E ++ D I
Sbjct: 1328 KAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRT 1387
Query: 570 -KTEHYKTDLHSPRGQASDSINPMSRVLSPLSPQISPCSSTRSLTSYSLCKTHSLPSALD 628
+ E K L +A ++ + + L L ++H+ + LD
Sbjct: 1388 EELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATLD 1447
Query: 629 TNEANFSDTMSESMNDQEEFISSCSLPVSPLGSIATRFLEEEELRSHHILERLDAHIEEL 688
+ NF ++E +E S L + S R L E + + E + +E L
Sbjct: 1448 KKQRNFDKVLAEWKQKLDE--SQAELEAAQKES---RSLSTELFKMRNAYEEVVDQLETL 1502
Query: 689 KRESEKTVRQFTAL 702
+RE++ + + L
Sbjct: 1503 RRENKNLQEEISDL 1516
Score = 57.4 bits (137), Expect = 4e-08
Identities = 93/469 (19%), Positives = 181/469 (38%), Gaps = 63/469 (13%)
Query: 192 KQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQK 251
K L+S E ++ E+ + ER + + +E + L ++ L+ + + Q +
Sbjct: 841 KPLLKSAE--AEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSE 898
Query: 252 EEKLRESEKLLEALQEEK-------RELKAALQSQENLIHEARIQKEKLQEKVKA----- 299
E L ++E+ E L + K +EL L+ +E + E +K L++K +
Sbjct: 899 TENLMDAEERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDI 958
Query: 300 -------TNTQHAVEAIRPREESLAEKKYT-SQGQGDLDSVLSQLNFTHTSE-DLLQAEV 350
T + A + ++L+E+ + L L H D LQ E
Sbjct: 959 DDLELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEE 1018
Query: 351 TCLEGSLESVSATCKQLSQELMEKYEELKRMEAH----NNEYKAEIKKLKEQILQGE--- 403
+ G L ++A +Q + +L E+ K++ A + + ++K +E I+ E
Sbjct: 1019 DKVNG-LIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDK 1077
Query: 404 QSYSSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKR-------------LRAEMQ 450
Q L+ + E+S L ++ + + +++ R LRA+++
Sbjct: 1078 QQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIE 1137
Query: 451 K-AEDKAVEHKEILDQLESLKLENRHLSEMVMKLELGL-------------HEAKEISLA 496
K D A E +EI ++LE EM K E HEA +L
Sbjct: 1138 KQRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLR 1197
Query: 497 DLQENYIEALNKLVSENQQLQKDLMNTKSQLEISTQMCKKQNDRIFKPTHS-----RTTE 551
Q + + L + + Q++++ L KS+L++ + + K + RT E
Sbjct: 1198 KKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVE 1257
Query: 552 FKNTEFKPTHGQHRHDGIKTEHYKTDLHSPRGQASDSINPMSRVLSPLS 600
+ +E K Q K L + G+ S + ++S L+
Sbjct: 1258 DQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLT 1306
Score = 50.8 bits (120), Expect = 4e-06
Identities = 85/407 (20%), Positives = 166/407 (40%), Gaps = 62/407 (15%)
Query: 22 EAELQELMKQIDIMVAHKKSEWE----GRTHALETCLKIREQELKSLRSQL--------D 69
+ EL ++ ++D V K E E A E + + E++S L D
Sbjct: 1566 QLELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKMEGD 1625
Query: 70 VTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNT 129
+ E+ + H + E K T++ + + +LH + + RS E L K+Q+
Sbjct: 1626 LNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDAL--RSNEDL-KEQLAIVERRN 1682
Query: 130 KNHREDRSEIERLTAKIEEFR----QKSLDW-EKQRLIYQQQVSSLEAQRKALAEQSEII 184
E+ E++ + E R Q+ LD ++ +L++ Q S + ++K A+ ++
Sbjct: 1683 GLLLEELEEMKVALEQTERTRRLSEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQC- 1741
Query: 185 QAQLVNRKQKLESVELSSQSEIQH---LSSKLERANDTICANELEIERLTMRVNDLVGTS 241
QA++ N Q+ + E ++ I ++ +L++ DT +ER+ + V
Sbjct: 1742 QAEVENSIQESRNAEEKAKKAITDAAMMAEELKKEQDT----SAHLERMKKNLEQTVKDL 1797
Query: 242 MTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATN 301
L E +Q L+ +K ++ L+ REL+ L ++ EA K + KV
Sbjct: 1798 QHRLDEAEQLA--LKGGKKQIQKLENRVRELENELDVEQKRGAEALKGAHKYERKV---- 1851
Query: 302 TQHAVEAIRPREESLAEKKYTSQGQGDLDSVLSQLNFTHTSEDLLQAEVTCLEGSLESVS 361
K+ T Q + D ++L + D LQA+V + E
Sbjct: 1852 -----------------KEMTYQAEEDHKNILRLQDLV----DKLQAKVKSYKRQAEEAE 1890
Query: 362 -------ATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQ 401
+ C+++ EL E E E+ N+ +A+ + + Q ++
Sbjct: 1891 EQANTQLSRCRRVQHELEEAAERADIAESQVNKLRAKSRDVGSQKME 1937
Score = 43.1 bits (100), Expect = 9e-04
Identities = 42/195 (21%), Positives = 93/195 (47%), Gaps = 25/195 (12%)
Query: 20 SCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTH------- 72
+ E + ++ + +M K E + H LE K EQ +K L+ +LD
Sbjct: 1754 NAEEKAKKAITDAAMMAEELKKEQDTSAH-LERMKKNLEQTVKDLQHRLDEAEQLALKGG 1812
Query: 73 -KEVGMLHQQVEEHEKIKQEMTMEYK---QELKKLHEELCILKRSYEKLQKKQMREFRGN 128
K++ L +V E ++ E+ +E K + LK H+ YE+ K+ + +
Sbjct: 1813 KKQIQKLENRVRE---LENELDVEQKRGAEALKGAHK--------YERKVKEMTYQAEED 1861
Query: 129 TKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQL 188
KN + +++L AK++ +++++ + E+Q + ++ + + AE+++I ++Q+
Sbjct: 1862 HKNILRLQDLVDKLQAKVKSYKRQAEEAEEQANTQLSRCRRVQHELEEAAERADIAESQV 1921
Query: 189 VNRKQKLESVELSSQ 203
K + +S ++ SQ
Sbjct: 1922 --NKLRAKSRDVGSQ 1934
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 97.8 bits (242), Expect = 3e-20
Identities = 139/568 (24%), Positives = 259/568 (45%), Gaps = 89/568 (15%)
Query: 41 SEWEGRTHALETCLKIREQELKS-----------LRSQLDVTHKEVGMLHQQVEEHEKIK 89
S ++ R H +E K R +ELK L QL+ T LH+ +E+ ++K
Sbjct: 330 SRYKERLHDIEF-YKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLK 388
Query: 90 ---QEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDRSEIERLTAKI 146
+M ME + KK+ EEL + E QK+ M E + + + +I R T+++
Sbjct: 389 AKLHDMEMERDMDRKKI-EELMEENMTLEMAQKQSMDE----SLHLGWELEQISR-TSEL 442
Query: 147 EEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESVELSSQSEI 206
E QKSL E L ++ LE + ++L + E ++ + + + + L + E
Sbjct: 443 SEAPQKSLGHEVNELT-SSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKI-LKMEKEN 500
Query: 207 QHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKE---EKLRE-SEKLL 262
Q LS K+E I NE+ E+ +++ + S +++E+ Q E E LRE SE+ +
Sbjct: 501 QRLSKKVE-----ILENEIVQEKQSLQ--NCQNLSKDLMKEKAQLEKTIETLRENSERQI 553
Query: 263 EALQEEKRELK---AALQSQENLIHEAR---IQKEK--LQEKVKATNTQHAVEAIRPREE 314
+ L++E L ++L+ + + EAR I+KE L E +K T+++ + R+
Sbjct: 554 KILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQI 613
Query: 315 SLAEKKYTSQGQGDLDSVLSQLNFTHTSEDLLQAEVTCLEGSLESVSATCKQLSQELMEK 374
+ Y +G+ + + ++L+ +LLQ ++T ++ TC
Sbjct: 614 KKELEHYKEKGE-RAEELENELHHLEKENELLQKKIT-------NLKITC---------- 655
Query: 375 YEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHLTQELHQRDITIAST 434
E+++ +E N+E + E +KLK + L ++ + LE ++ E S L +E + + S
Sbjct: 656 -EKIEALEQENSELERENRKLK-KTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESL 713
Query: 435 KGSSSDM------EKRLRAEMQ---------KAEDKAVEHKEILDQLESLKLENRHL--- 476
K +S M K L +E + KA K E E+ + L +EN+ L
Sbjct: 714 KCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEV--SYQGLDIENQRLQKT 771
Query: 477 ----SEMVMKLELGLHEAKEISLADLQENY--IEALNKLVSENQQLQKDLMNTKSQLEIS 530
++ + +LE L + E+ LQ+N ++ +K + + ++ K L SQLE
Sbjct: 772 LENSNKKIQQLESELQDL-EMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKD 830
Query: 531 TQMCKKQNDRIFKPTHSRTTEFKNTEFK 558
+ +K+N R+ + + T + K
Sbjct: 831 KKQLEKENKRLRQQAEIKDTTLEENNVK 858
Score = 90.5 bits (223), Expect = 5e-18
Identities = 112/514 (21%), Positives = 242/514 (47%), Gaps = 73/514 (14%)
Query: 24 ELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKS-LRSQLDVTHKEVGMLHQQV 82
+L++L +++ + +K+ ++ K+ E +L+S L+ L++ +++ L ++
Sbjct: 924 DLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARL 983
Query: 83 EEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMRE--FRGNTKNHREDRS--- 137
EE + Y Q+L+ +EL +K++YE L+++Q E + + ED
Sbjct: 984 EE--------STNYNQQLR---QELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWER 1032
Query: 138 EIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLES 197
E + T ++ + + + ++ E+ Q + +L+ Q K L Q+ +QAQ++ +++ S
Sbjct: 1033 ESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVS 1092
Query: 198 VELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRE 257
++ + +Q ++KL+ N T+ + + M N + + L+ + + K RE
Sbjct: 1093 LQ-EQNTTLQTQNAKLQVENSTLNSQSTSL----MNQNAQLLIQQSSLENENESVIKERE 1147
Query: 258 SEK-LLEALQEEKRELKAALQSQENLIHEARIQK-EKLQEKVKATNTQHAVEAIRPRE-E 314
K L ++L ++ +L+ L+HE + + E L K + H + R+ E
Sbjct: 1148 DLKSLYDSLIKDHEKLE--------LLHERQASEYESLISKHGTLKSAHKNLEVEHRDLE 1199
Query: 315 SLAEKKYTSQGQ-GDLDSVLS----QLNFTHTSEDLLQAEVTCLEGSLESVSATCKQLSQ 369
+ +GQ DL+ +L ++ + + + + AE L G + ++ T QL +
Sbjct: 1200 DRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLK 1259
Query: 370 ELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHLTQELHQRDI 429
E + K +++ N K E +L+ E S L ++ Q DI
Sbjct: 1260 ETEVLQTDHKNLKSLLNNSKLEQTRLEA------------------EFSKLKEQYQQLDI 1301
Query: 430 TIASTK-GSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMVMKLELGLH 488
T STK + ++ +L+ +++ E++ +LDQ+++L L+NR L E M
Sbjct: 1302 T--STKLNNQCELLSQLKGNLEE------ENRHLLDQIQTLMLQNRTLLEQNM------- 1346
Query: 489 EAKEISLADLQENYIEALNKLVSENQQLQKDLMN 522
E+K++ + Q YI+ LN+L + ++L++ +M+
Sbjct: 1347 ESKDLFHVE-QRQYIDKLNELRRQKEKLEEKIMD 1379
Score = 81.3 bits (199), Expect = 3e-15
Identities = 134/565 (23%), Positives = 238/565 (42%), Gaps = 83/565 (14%)
Query: 18 LTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGM 77
L E E Q L K ++ + K R LE K EQE L KE
Sbjct: 786 LQDLEMENQTLQKNLEELKISSK-----RLEQLEKENKSLEQETSQLEKDKKQLEKENKR 840
Query: 78 LHQQVEEHEKIKQEMTMEY---KQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHRE 134
L QQ E + +E ++ ++E K L +E+ I K S +L++ + +E
Sbjct: 841 LRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELE-----------KE 889
Query: 135 DRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQK 194
++ ++R T I+ D ++L QQ + LE L + E I +N+++
Sbjct: 890 NKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEK----LTHELEKIG---LNKERL 942
Query: 195 LESVELSSQSEIQHLSSKLERA--------NDTICANELEIERLTMRVNDLVGTSMTVLQ 246
L + + S + L SKLE + I A E +E T L TV +
Sbjct: 943 LHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKK 1002
Query: 247 -----EQQQKEEKLRESE--------KLLEALQEEKRELKAALQSQENLIHEAR------ 287
+Q+Q EE++ +S K QE REL L+ ++ LI R
Sbjct: 1003 NYEALKQRQDEERMVQSSPPISGEDNKWERESQETTREL---LKVKDRLIEVERNNATLQ 1059
Query: 288 IQKEKLQEKVKATNTQH-----AVEAIRPREESLAEKKYTSQGQG-DLDSVLSQLNFTHT 341
+K+ L+ ++K TQ+ + A++ + SL E+ T Q Q L S LN T
Sbjct: 1060 AEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQST 1119
Query: 342 SEDLLQAEVTCLEGSLESVSATCKQLSQELMEKYEEL----KRMEAHNNEYKAEIKKLKE 397
S A++ + SLE+ + + + ++L Y+ L +++E + +E E
Sbjct: 1120 SLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEY----E 1175
Query: 398 QILQGEQSYSSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAV 457
++ + SA + +++E L +Q + KG D+EK L+ E +K +
Sbjct: 1176 SLISKHGTLKSAHKNLEVEHRDLEDRYNQ----LLKQKGQLEDLEKMLKVEQEKMLLENK 1231
Query: 458 EHKEILDQLESLKLENRHL----SEMVMKLELGLHEAKE----ISLADLQENYIEA-LNK 508
H+ + + + L EN L S+++ + E+ + K ++ + L++ +EA +K
Sbjct: 1232 NHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSK 1291
Query: 509 LVSENQQLQKDLMNTKSQLEISTQM 533
L + QQL +Q E+ +Q+
Sbjct: 1292 LKEQYQQLDITSTKLNNQCELLSQL 1316
Score = 69.7 bits (169), Expect = 9e-12
Identities = 109/496 (21%), Positives = 213/496 (42%), Gaps = 53/496 (10%)
Query: 69 DVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEE---LCILKRSYEKLQKKQMREF 125
D++ +++ L + + H K + E+ + + +L EE L L + Q
Sbjct: 180 DMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPG 239
Query: 126 RGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQ 185
T++ + E+ AKI RQ+ + +Q L +Q++ +E + K L +++
Sbjct: 240 MKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQEN---- 295
Query: 186 AQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVL 245
+N S + + E+ L K R + E E+ R R++D+ V
Sbjct: 296 ---MNLLSDARSARM-YRDELDALREKAVRVDKL----ESEVSRYKERLHDIEFYKARV- 346
Query: 246 QEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATNTQHA 305
+E ++ + L E++ +LE E R ++ + +HE ++KE LQ K K + +
Sbjct: 347 EELKEDNQVLLETKTMLEDQLEGTR-------ARSDKLHE--LEKENLQLKAKLHDMEME 397
Query: 306 VEAIRPREESLAEKKYTSQGQGDLDSVLSQLNFTHTSEDLLQAEVTCLEGSLESVSATCK 365
+ R + E L E+ T ++ S H +L Q T E A K
Sbjct: 398 RDMDRKKIEELMEENMTL----EMAQKQSMDESLHLGWELEQISRTS-----ELSEAPQK 448
Query: 366 QLSQELME-KYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSAL------EGMKMEIS 418
L E+ E L ++E N +++L+ + E + S L + + ++
Sbjct: 449 SLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVE 508
Query: 419 HLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSE 478
L E+ Q ++ + + S D+ K +A+++K + E+ E Q++ L+ EN HL++
Sbjct: 509 ILENEIVQEKQSLQNCQNLSKDLMKE-KAQLEKTIETLRENSE--RQIKILEQENEHLNQ 565
Query: 479 MVMKLELGLHEAKEISLADLQENYIEALNKLVSENQQLQKDLMNTKSQLEISTQMCKKQN 538
V L + +IS A+ + IE NK++ E+ K+ + S++E + KK+
Sbjct: 566 TVS----SLRQRSQIS-AEARVKDIEKENKILHES---IKETSSKLSKIEFEKRQIKKEL 617
Query: 539 DRIFKPTHSRTTEFKN 554
+ +K R E +N
Sbjct: 618 EH-YKEKGERAEELEN 632
Score = 59.7 bits (143), Expect = 9e-09
Identities = 81/400 (20%), Positives = 175/400 (43%), Gaps = 59/400 (14%)
Query: 228 ERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEAR 287
+ L++ + D + QE ++K E+L + ++ LE ++ E + L+ Q NL+ +AR
Sbjct: 247 QHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQ---QENMNLLSDAR 303
Query: 288 ----------------IQKEKLQEKVKATNTQ-HAVEAIRPREESLAEKKYT-----SQG 325
++ +KL+ +V + H +E + R E L E +
Sbjct: 304 SARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTML 363
Query: 326 QGDLDSVLSQLNFTHTSE-----------------DLLQAEVTCLEGSLESVSATCKQLS 368
+ L+ ++ + H E D+ + ++ L ++ KQ
Sbjct: 364 EDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSM 423
Query: 369 QELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHLTQELHQRD 428
E + EL+++ + +A K L ++ + SS L ++ME LT+ + +
Sbjct: 424 DESLHLGWELEQISRTSELSEAPQKSLGHEV---NELTSSRLLKLEMENQSLTKTVEELR 480
Query: 429 ITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMVMKLELGLH 488
T+ S +G++S + K + + ++ + EI+ + +SL+ ++LS+ +MK + L
Sbjct: 481 TTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQ-NCQNLSKDLMKEKAQL- 538
Query: 489 EAKEISLADLQENYIEALNKLVSENQQLQKDLMNTKSQLEISTQM----CKKQNDRI--- 541
E ++ L+EN + L EN+ L + + + + + +IS + +K+N +
Sbjct: 539 ---EKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHES 595
Query: 542 FKPTHSRTT--EFKNTEFKPTHGQHRHDGIKTEHYKTDLH 579
K T S+ + EF+ + K ++ G + E + +LH
Sbjct: 596 IKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELH 635
Score = 40.8 bits (94), Expect = 0.004
Identities = 69/361 (19%), Positives = 133/361 (36%), Gaps = 39/361 (10%)
Query: 353 LEGSLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQIL------QGEQSY 406
L L A ++L QEL EK E+L + + + E+K+L+++ + + + Y
Sbjct: 249 LSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMY 308
Query: 407 SSALEGMK----------MEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKA 456
L+ ++ E+S + LH + A + D + L + ED+
Sbjct: 309 RDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTM-LEDQL 367
Query: 457 VEHKEILDQLESLKLENRHLSEMV--MKLELGLHEAKEISLADLQENYIEALNKLVSENQ 514
+ D+L L+ EN L + M++E + K L + A + + E+
Sbjct: 368 EGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESL 427
Query: 515 QLQKDLMNTKSQLEISTQMCKKQNDRIFKPTHSR--TTEFKNTEFKPTHGQHRHDGIKTE 572
L +L E+S K + + T SR E +N T E
Sbjct: 428 HLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKT----------VE 477
Query: 573 HYKTDLHSPRGQASDSINPMSRVLSPLSPQISPCSSTRSLTSYSLCKTHSLPSALDTNEA 632
+T + S G AS I M + LS ++ + SL +L L +A
Sbjct: 478 ELRTTVDSVEGNAS-KILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKA 536
Query: 633 NFSDTMSESMNDQEEFISSCSLPVSPLGSIATRFLEEEELRSHHILERLDAHIEELKRES 692
T+ + E I L + + ++ + +A ++++++E+
Sbjct: 537 QLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISA-------EARVKDIEKEN 589
Query: 693 E 693
+
Sbjct: 590 K 590
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 97.8 bits (242), Expect = 3e-20
Identities = 139/568 (24%), Positives = 259/568 (45%), Gaps = 89/568 (15%)
Query: 41 SEWEGRTHALETCLKIREQELKS-----------LRSQLDVTHKEVGMLHQQVEEHEKIK 89
S ++ R H +E K R +ELK L QL+ T LH+ +E+ ++K
Sbjct: 330 SRYKERLHDIEF-YKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLK 388
Query: 90 ---QEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDRSEIERLTAKI 146
+M ME + KK+ EEL + E QK+ M E + + + +I R T+++
Sbjct: 389 AKLHDMEMERDMDRKKI-EELMEENMTLEMAQKQSMDE----SLHLGWELEQISR-TSEL 442
Query: 147 EEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESVELSSQSEI 206
E QKSL E L ++ LE + ++L + E ++ + + + + L + E
Sbjct: 443 SEAPQKSLGHEVNELT-SSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKI-LKMEKEN 500
Query: 207 QHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKE---EKLRE-SEKLL 262
Q LS K+E I NE+ E+ +++ + S +++E+ Q E E LRE SE+ +
Sbjct: 501 QRLSKKVE-----ILENEIVQEKQSLQ--NCQNLSKDLMKEKAQLEKTIETLRENSERQI 553
Query: 263 EALQEEKRELK---AALQSQENLIHEAR---IQKEK--LQEKVKATNTQHAVEAIRPREE 314
+ L++E L ++L+ + + EAR I+KE L E +K T+++ + R+
Sbjct: 554 KILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQI 613
Query: 315 SLAEKKYTSQGQGDLDSVLSQLNFTHTSEDLLQAEVTCLEGSLESVSATCKQLSQELMEK 374
+ Y +G+ + + ++L+ +LLQ ++T ++ TC
Sbjct: 614 KKELEHYKEKGE-RAEELENELHHLEKENELLQKKIT-------NLKITC---------- 655
Query: 375 YEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHLTQELHQRDITIAST 434
E+++ +E N+E + E +KLK + L ++ + LE ++ E S L +E + + S
Sbjct: 656 -EKIEALEQENSELERENRKLK-KTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESL 713
Query: 435 KGSSSDM------EKRLRAEMQ---------KAEDKAVEHKEILDQLESLKLENRHL--- 476
K +S M K L +E + KA K E E+ + L +EN+ L
Sbjct: 714 KCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEV--SYQGLDIENQRLQKT 771
Query: 477 ----SEMVMKLELGLHEAKEISLADLQENY--IEALNKLVSENQQLQKDLMNTKSQLEIS 530
++ + +LE L + E+ LQ+N ++ +K + + ++ K L SQLE
Sbjct: 772 LENSNKKIQQLESELQDL-EMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKD 830
Query: 531 TQMCKKQNDRIFKPTHSRTTEFKNTEFK 558
+ +K+N R+ + + T + K
Sbjct: 831 KKQLEKENKRLRQQAEIKDTTLEENNVK 858
Score = 89.0 bits (219), Expect = 1e-17
Identities = 109/483 (22%), Positives = 228/483 (47%), Gaps = 73/483 (15%)
Query: 55 KIREQELKS-LRSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRS 113
K+ E +L+S L+ L++ +++ L ++EE + Y Q+L+ +EL +K++
Sbjct: 954 KLLESKLESTLKKSLEIKEEKIAALEARLEE--------STNYNQQLR---QELKTVKKN 1002
Query: 114 YEKLQKKQMRE--FRGNTKNHREDRS---EIERLTAKIEEFRQKSLDWEKQRLIYQQQVS 168
YE L+++Q E + + ED E + T ++ + + + ++ E+ Q +
Sbjct: 1003 YEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQ 1062
Query: 169 SLEAQRKALAEQSEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIE 228
+L+ Q K L Q+ +QAQ++ +++ S++ + +Q ++KL+ N T+ + +
Sbjct: 1063 ALKTQLKQLETQNNNLQAQILALQRQTVSLQ-EQNTTLQTQNAKLQVENSTLNSQSTSL- 1120
Query: 229 RLTMRVNDLVGTSMTVLQEQQQKEEKLRESEK-LLEALQEEKRELKAALQSQENLIHEAR 287
M N + + L+ + + K RE K L ++L ++ +L+ L+HE +
Sbjct: 1121 ---MNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLE--------LLHERQ 1169
Query: 288 IQK-EKLQEKVKATNTQHAVEAIRPRE-ESLAEKKYTSQGQ-GDLDSVLS----QLNFTH 340
+ E L K + H + R+ E + +GQ DL+ +L ++ +
Sbjct: 1170 ASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLEN 1229
Query: 341 TSEDLLQAEVTCLEGSLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQIL 400
+ + + AE L G + ++ T QL +E + K +++ N K E +L+
Sbjct: 1230 KNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEA--- 1286
Query: 401 QGEQSYSSALEGMKMEISHLTQELHQRDITIASTK-GSSSDMEKRLRAEMQKAEDKAVEH 459
E S L ++ Q DIT STK + ++ +L+ +++ E+
Sbjct: 1287 ---------------EFSKLKEQYQQLDIT--STKLNNQCELLSQLKGNLEE------EN 1323
Query: 460 KEILDQLESLKLENRHLSEMVMKLELGLHEAKEISLADLQENYIEALNKLVSENQQLQKD 519
+ +LDQ+++L L+NR L E M E+K++ + Q YI+ LN+L + ++L++
Sbjct: 1324 RHLLDQIQTLMLQNRTLLEQNM-------ESKDLFHVE-QRQYIDKLNELRRQKEKLEEK 1375
Query: 520 LMN 522
+M+
Sbjct: 1376 IMD 1378
Score = 82.0 bits (201), Expect = 2e-15
Identities = 131/558 (23%), Positives = 239/558 (42%), Gaps = 70/558 (12%)
Query: 18 LTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGM 77
L E E Q L K ++ + K R LE K EQE L KE
Sbjct: 786 LQDLEMENQTLQKNLEELKISSK-----RLEQLEKENKSLEQETSQLEKDKKQLEKENKR 840
Query: 78 LHQQVEEHEKIKQEMTMEY---KQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHRE 134
L QQ E + +E ++ ++E K L +E+ I K S +L++ + +E
Sbjct: 841 LRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELE-----------KE 889
Query: 135 DRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQK 194
++ ++R T I+ D ++L QQ + LE L E+ + + +L++ +Q
Sbjct: 890 NKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHEL-EKIGLNKERLLHDEQS 948
Query: 195 LESVELSSQSEIQH-LSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQ-----EQ 248
+ +S+++ L LE + I A E +E T L TV + +Q
Sbjct: 949 TDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQ 1008
Query: 249 QQKEEKLRESE--------KLLEALQEEKRELKAALQSQENLIHEAR------IQKEKLQ 294
+Q EE++ +S K QE REL L+ ++ LI R +K+ L+
Sbjct: 1009 RQDEERMVQSSPPISGEDNKWERESQETTREL---LKVKDRLIEVERNNATLQAEKQALK 1065
Query: 295 EKVKATNTQH-----AVEAIRPREESLAEKKYTSQGQG-DLDSVLSQLNFTHTSEDLLQA 348
++K TQ+ + A++ + SL E+ T Q Q L S LN TS A
Sbjct: 1066 TQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNA 1125
Query: 349 EVTCLEGSLESVSATCKQLSQELMEKYEEL----KRMEAHNNEYKAEIKKLKEQILQGEQ 404
++ + SLE+ + + + ++L Y+ L +++E + +E E ++
Sbjct: 1126 QLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEY----ESLISKHG 1181
Query: 405 SYSSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILD 464
+ SA + +++E L +Q + KG D+EK L+ E +K + H+ +
Sbjct: 1182 TLKSAHKNLEVEHRDLEDRYNQ----LLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAA 1237
Query: 465 QLESLKLENRHL----SEMVMKLELGLHEAKE----ISLADLQENYIEA-LNKLVSENQQ 515
+ + L EN L S+++ + E+ + K ++ + L++ +EA +KL + QQ
Sbjct: 1238 EYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQ 1297
Query: 516 LQKDLMNTKSQLEISTQM 533
L +Q E+ +Q+
Sbjct: 1298 LDITSTKLNNQCELLSQL 1315
Score = 69.7 bits (169), Expect = 9e-12
Identities = 109/496 (21%), Positives = 213/496 (42%), Gaps = 53/496 (10%)
Query: 69 DVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEE---LCILKRSYEKLQKKQMREF 125
D++ +++ L + + H K + E+ + + +L EE L L + Q
Sbjct: 180 DMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPG 239
Query: 126 RGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQ 185
T++ + E+ AKI RQ+ + +Q L +Q++ +E + K L +++
Sbjct: 240 MKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQEN---- 295
Query: 186 AQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVL 245
+N S + + E+ L K R + E E+ R R++D+ V
Sbjct: 296 ---MNLLSDARSARM-YRDELDALREKAVRVDKL----ESEVSRYKERLHDIEFYKARV- 346
Query: 246 QEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATNTQHA 305
+E ++ + L E++ +LE E R ++ + +HE ++KE LQ K K + +
Sbjct: 347 EELKEDNQVLLETKTMLEDQLEGTR-------ARSDKLHE--LEKENLQLKAKLHDMEME 397
Query: 306 VEAIRPREESLAEKKYTSQGQGDLDSVLSQLNFTHTSEDLLQAEVTCLEGSLESVSATCK 365
+ R + E L E+ T ++ S H +L Q T E A K
Sbjct: 398 RDMDRKKIEELMEENMTL----EMAQKQSMDESLHLGWELEQISRTS-----ELSEAPQK 448
Query: 366 QLSQELME-KYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSAL------EGMKMEIS 418
L E+ E L ++E N +++L+ + E + S L + + ++
Sbjct: 449 SLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVE 508
Query: 419 HLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSE 478
L E+ Q ++ + + S D+ K +A+++K + E+ E Q++ L+ EN HL++
Sbjct: 509 ILENEIVQEKQSLQNCQNLSKDLMKE-KAQLEKTIETLRENSE--RQIKILEQENEHLNQ 565
Query: 479 MVMKLELGLHEAKEISLADLQENYIEALNKLVSENQQLQKDLMNTKSQLEISTQMCKKQN 538
V L + +IS A+ + IE NK++ E+ K+ + S++E + KK+
Sbjct: 566 TVS----SLRQRSQIS-AEARVKDIEKENKILHES---IKETSSKLSKIEFEKRQIKKEL 617
Query: 539 DRIFKPTHSRTTEFKN 554
+ +K R E +N
Sbjct: 618 EH-YKEKGERAEELEN 632
Score = 59.7 bits (143), Expect = 9e-09
Identities = 81/400 (20%), Positives = 175/400 (43%), Gaps = 59/400 (14%)
Query: 228 ERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEAR 287
+ L++ + D + QE ++K E+L + ++ LE ++ E + L+ Q NL+ +AR
Sbjct: 247 QHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQ---QENMNLLSDAR 303
Query: 288 ----------------IQKEKLQEKVKATNTQ-HAVEAIRPREESLAEKKYT-----SQG 325
++ +KL+ +V + H +E + R E L E +
Sbjct: 304 SARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTML 363
Query: 326 QGDLDSVLSQLNFTHTSE-----------------DLLQAEVTCLEGSLESVSATCKQLS 368
+ L+ ++ + H E D+ + ++ L ++ KQ
Sbjct: 364 EDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSM 423
Query: 369 QELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHLTQELHQRD 428
E + EL+++ + +A K L ++ + SS L ++ME LT+ + +
Sbjct: 424 DESLHLGWELEQISRTSELSEAPQKSLGHEV---NELTSSRLLKLEMENQSLTKTVEELR 480
Query: 429 ITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMVMKLELGLH 488
T+ S +G++S + K + + ++ + EI+ + +SL+ ++LS+ +MK + L
Sbjct: 481 TTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQ-NCQNLSKDLMKEKAQL- 538
Query: 489 EAKEISLADLQENYIEALNKLVSENQQLQKDLMNTKSQLEISTQM----CKKQNDRI--- 541
E ++ L+EN + L EN+ L + + + + + +IS + +K+N +
Sbjct: 539 ---EKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHES 595
Query: 542 FKPTHSRTT--EFKNTEFKPTHGQHRHDGIKTEHYKTDLH 579
K T S+ + EF+ + K ++ G + E + +LH
Sbjct: 596 IKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELH 635
Score = 40.8 bits (94), Expect = 0.004
Identities = 69/361 (19%), Positives = 133/361 (36%), Gaps = 39/361 (10%)
Query: 353 LEGSLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQIL------QGEQSY 406
L L A ++L QEL EK E+L + + + E+K+L+++ + + + Y
Sbjct: 249 LSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMY 308
Query: 407 SSALEGMK----------MEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKA 456
L+ ++ E+S + LH + A + D + L + ED+
Sbjct: 309 RDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTM-LEDQL 367
Query: 457 VEHKEILDQLESLKLENRHLSEMV--MKLELGLHEAKEISLADLQENYIEALNKLVSENQ 514
+ D+L L+ EN L + M++E + K L + A + + E+
Sbjct: 368 EGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESL 427
Query: 515 QLQKDLMNTKSQLEISTQMCKKQNDRIFKPTHSR--TTEFKNTEFKPTHGQHRHDGIKTE 572
L +L E+S K + + T SR E +N T E
Sbjct: 428 HLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKT----------VE 477
Query: 573 HYKTDLHSPRGQASDSINPMSRVLSPLSPQISPCSSTRSLTSYSLCKTHSLPSALDTNEA 632
+T + S G AS I M + LS ++ + SL +L L +A
Sbjct: 478 ELRTTVDSVEGNAS-KILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKA 536
Query: 633 NFSDTMSESMNDQEEFISSCSLPVSPLGSIATRFLEEEELRSHHILERLDAHIEELKRES 692
T+ + E I L + + ++ + +A ++++++E+
Sbjct: 537 QLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISA-------EARVKDIEKEN 589
Query: 693 E 693
+
Sbjct: 590 K 590
>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
sapiens]
Length = 1940
Score = 97.4 bits (241), Expect = 4e-20
Identities = 162/789 (20%), Positives = 325/789 (41%), Gaps = 126/789 (15%)
Query: 18 LTSCEAELQELMKQIDIMVAHKKS---EWEGRTHALETCLKIREQELKSL---RSQLDVT 71
L +++L++ ++ ++ + +K + E LE LK+ ++ + L + QLD
Sbjct: 1021 LNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDER 1080
Query: 72 HKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTKN 131
K+ + Q++ + +Q + +++++++K+L + L+ E R R T+
Sbjct: 1081 LKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEA-----ERATRAKTEK 1135
Query: 132 HREDRS-EIERLTAKIEE------------------FRQKSLDWEKQRLIYQQQVSSLEA 172
R D + E+E L+ ++EE F + D E+ L ++ V++L
Sbjct: 1136 QRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVAALRK 1195
Query: 173 QRK-ALAEQSEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLT 231
+ ++AE E I L KQKLE + + EI LSS +E ++ ++ +E++
Sbjct: 1196 KHADSVAELGEQID-NLQRVKQKLEKEKSEFKLEIDDLSSSME----SVSKSKANLEKIC 1250
Query: 232 MRVNDLVGTSMTVLQEQQ--------QKEEKLRESEKLLEALQEEKRELKAALQSQENLI 283
+ D + + +E Q QK E+ +L L+E++ + +S++
Sbjct: 1251 RTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFT 1310
Query: 284 HEARIQKEKLQEKVKATNT-QHAVEAIRPREESLAEKKYTSQ-GQGDLDSVLSQLNFTHT 341
+ K +L+E+ KA N HA+++ R + L E+ Q G+ +L LS+ N +
Sbjct: 1311 QQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKAN-SEV 1369
Query: 342 SEDLLQAEVTCLEGSLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQ 401
++ + E ++ + E + K+L+Q L + E+++ + A A ++K K++ LQ
Sbjct: 1370 AQWRTKYETDAIQRT-EELEEAKKKLAQRLQDSEEQVEAVNAKC----ASLEKTKQR-LQ 1423
Query: 402 GE-QSYSSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVE-- 458
GE + +E + L ++ D +A K + + L A ++++ + E
Sbjct: 1424 GEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELF 1483
Query: 459 -----HKEILDQLESLKLENRHLSEMVMKL-----ELG--LHEAK------EISLADLQE 500
++E LDQLE++K EN++L + + L E G +HE + E+ AD+Q
Sbjct: 1484 KLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQL 1543
Query: 501 NYIEALNKLVSENQQLQK-DLMNTKSQLEISTQMCKKQND-RIFKPTHSRTTEFKNTEF- 557
EA L E ++ + L T+ + EI ++ +K + K + RT E +
Sbjct: 1544 ALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALD 1603
Query: 558 -------------KPTHGQHRHDGIKTEHYKTD-------LHSPRGQASDS--------- 588
K G I+ H L S +GQ D+
Sbjct: 1604 AEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALR 1663
Query: 589 ---------------INPMSRVLSPLSPQISPCSSTRSLTSYSLCKTHSLPSALDTNEAN 633
N + + L + R L L ++ L T +
Sbjct: 1664 GQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTS 1723
Query: 634 FSDTMSESMNDQEEF---ISSCSLPVSPLGSIATRFLEEEELRSHHILERLD--AHIEEL 688
T + D + + S A + + + + + + + D AH+E +
Sbjct: 1724 LIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERM 1783
Query: 689 KRESEKTVR 697
K+ E+TV+
Sbjct: 1784 KKNLEQTVK 1792
Score = 88.2 bits (217), Expect = 2e-17
Identities = 109/579 (18%), Positives = 250/579 (43%), Gaps = 54/579 (9%)
Query: 22 EAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQ 81
+AELQ + + + VA ++++E T A++ ++ E + K L +L + ++V ++ +
Sbjct: 1355 KAELQRALSKANSEVAQWRTKYE--TDAIQRTEELEEAK-KKLAQRLQDSEEQVEAVNAK 1411
Query: 82 VEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDRSEIER 141
EK KQ + E + + + E L + +K Q+ + E ++E+E
Sbjct: 1412 CASLEKTKQRLQGEVEDLMVDV-ERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELE- 1469
Query: 142 LTAKIEEFRQKSLDWEKQRLIYQQQVSSLEA---QRKALAEQSEIIQAQLVNRKQKLESV 198
A ++E R S + K + Y++ + LE + K L ++ + Q+ + + +
Sbjct: 1470 --ASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHEL 1527
Query: 199 ELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRES 258
E S+ +I+ LE+A+ + E E L ++ + + Q + + + K+ E
Sbjct: 1528 E-KSRKQIE-----LEKADIQLALEEAEAA-LEHEEAKILRIQLELTQVKSEIDRKIAEK 1580
Query: 259 EKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAIRPREESLAE 318
++ +E L+ + +QS + +R + +L++K++ + ++ ++
Sbjct: 1581 DEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAET 1640
Query: 319 KKYTSQGQGDL--------------DSVLSQLNFTHTSEDLLQAEVTCLEGSLESVSATC 364
K+ QG L + + QL +LLQAEV L +LE
Sbjct: 1641 LKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERAR 1700
Query: 365 KQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHLTQEL 424
K QEL++ E ++ + N KKL+ ++Q + A + +E
Sbjct: 1701 KLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARN-----AEEK 1755
Query: 425 HQRDITIASTKGSSSDMEKRLRAEMQKAED------KAVEHKEILDQLESLKLEN----- 473
++ IT A+ E+ A +++ + K ++H+ LD+ E L L+
Sbjct: 1756 AKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHR--LDEAEQLALKGGKKQI 1813
Query: 474 RHLSEMVMKLELGLHEAKEISLADLQ--ENYIEALNKLVSENQQLQKDLMNTK---SQLE 528
+ L + +LE L ++ + ++ Y + +L ++++ +K+++ + +L+
Sbjct: 1814 QKLETRIRELEFELEGEQKKNTESVKGLRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQ 1873
Query: 529 ISTQMCKKQNDRIFKPTHSRTTEFKNTEFKPTHGQHRHD 567
+ + K+Q + + ++ T+F+ + + + R D
Sbjct: 1874 VKVKSYKRQAEEADEQANAHLTKFRKAQHELEEAEERAD 1912
Score = 72.0 bits (175), Expect = 2e-12
Identities = 135/702 (19%), Positives = 294/702 (41%), Gaps = 104/702 (14%)
Query: 71 THKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTK 130
T KE+ + EE +K K E+ + + K+L E+L L + LQ + E N
Sbjct: 846 TEKEMATMK---EEFQKTKDELAKS-EAKRKELEEKLVTLVQEKNDLQLQVQAESE-NLL 900
Query: 131 NHREDRSEIER----LTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQA 186
+ E ++ + L AKI+E +++ D E+ + LE + L + + ++
Sbjct: 901 DAEERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLEL 960
Query: 187 QLVNRKQKLESVELSSQSEIQHLSSKLERANDTIC-----------ANELEIERLTM--- 232
L K+E + ++++++++L+ +L ++TI A++ ++ L
Sbjct: 961 TLA----KVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEED 1016
Query: 233 RVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEK 292
+VN L T + Q+ + E L + +KL L+ KR+L+ L+ + I + K++
Sbjct: 1017 KVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQ 1076
Query: 293 LQEKVKATNTQHAVEAIRPREESLAEKKYTSQGQGDLDSVLSQLNFTHTSEDLLQAEVTC 352
L E++K + ++ + +E ++ + + +L + + +L E+ ++AE
Sbjct: 1077 LDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIK-ELQARIEEL------EEEIEAERAT 1129
Query: 353 LEGSLESVSATCKQLSQELMEKYEELKRMEAH----NNEYKAEIKKLKEQILQGEQSYSS 408
+ + S ++L +EL E+ EE + + N + +AE KL+ + + + +
Sbjct: 1130 RAKTEKQRSDYAREL-EELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEA 1188
Query: 409 ALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDK-AVEHKEILDQLE 467
+ ++ + + EL G D +R++ +++K + + +E ++ +E
Sbjct: 1189 MVAALRKKHADSVAEL-----------GEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSME 1237
Query: 468 SLKLENRHLSEMVMKLELGLHEAK------EISLADL--QENYIEA----LNKLVSENQQ 515
S+ +L ++ LE L EA+ + SL++L Q++ ++ L++ + E +
Sbjct: 1238 SVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKES 1297
Query: 516 LQKDLMNTKSQLEISTQMCKKQNDRIFKP----THSRTTEFKNTEFKPTHGQHRHDGIKT 571
+ L +K T+ K+Q + K H+ + + + + +G K
Sbjct: 1298 IVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEG-KA 1356
Query: 572 E-----------------HYKTDLHSPRGQASDSINPMSRVLSPLSPQI----SPCSSTR 610
E Y+TD + ++ +++ L Q+ + C+S
Sbjct: 1357 ELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLE 1416
Query: 611 SLTS----------YSLCKTHSLPSALDTNEANFSDTMSESMNDQEEFISSCSLPVSPLG 660
+ + +SL +ALD + NF ++E EE S L S
Sbjct: 1417 KTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEE--SQAELEASLKE 1474
Query: 661 SIATRFLEEEELRSHHILERLDAHIEELKRESEKTVRQFTAL 702
S R L E + + E +E +KRE++ ++ L
Sbjct: 1475 S---RSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADL 1513
>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
Length = 1684
Score = 97.1 bits (240), Expect = 5e-20
Identities = 139/689 (20%), Positives = 310/689 (44%), Gaps = 80/689 (11%)
Query: 25 LQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQVEE 84
+ +L K++ +MV + + L L+ + + +++QL KE+G + E
Sbjct: 724 ITQLEKKLQLMVEEQDN--------LNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSE 775
Query: 85 HEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDRSEIERLTA 144
EK + + L K++EE C L ++++ +K E +E + E
Sbjct: 776 -EKDVVNVLQAVGESLAKINEEKCNL--AFQRDEKVLELE--------KEIKCLQEESVV 824
Query: 145 KIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESVELSSQS 204
+ EE + D+E+++++ ++++ ++++++AL QS++++ + N K +LE+
Sbjct: 825 QCEELKSLLRDYEQEKVLLRKELEEIQSEKEAL--QSDLLEMKNANEKTRLEN------- 875
Query: 205 EIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEA 264
Q+L ++E + T +E+ E+ + + ++ L EQ++ ++ E L ++
Sbjct: 876 --QNLLIQVEEVSQTCSKSEIHNEKEKCFIKE--HENLKPLLEQKELRDRRAELILLKDS 931
Query: 265 LQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAIRPREESLAEKKYTSQ 324
L + L S + L + +++ +EK + N V A++ ++E + +K T
Sbjct: 932 LAKSPSVKNDPLSSVKELEEKIENLEKECKEKEEKINKIKLV-AVKAKKELDSSRKETQT 990
Query: 325 GQGDLDSVLSQLNFTHTSEDLLQAEVTCLEGSLESVSATCKQLSQELMEKYEEL--KRME 382
+ +L+S+ S+ +D L A + L ES K L E ++ E+L ++
Sbjct: 991 VKEELESLRSE-------KDQLSASMRDLIQGAESY----KNLLLEYEKQSEQLDVEKER 1039
Query: 383 AHNNEYKAE--IKKLKEQILQGEQSYSSALEGMKMEISHLTQELHQRDITIASTKGSSSD 440
A+N E++ E ++L+ LQ E + +S E + I L ++ I + + +
Sbjct: 1040 ANNFEHRIEDLTRQLRNSTLQCE-TINSDNEDLLARIETLQSNAKLLEVQILEVQRAKAM 1098
Query: 441 MEKRLRAEMQKAEDKAVEHKEILDQLESLKL----ENRHLSEMVMKLELGLHEAKEISLA 496
++K L AE + E K EH +++LE L++ E + L + + +LEL +A++ +L
Sbjct: 1099 VDKELEAEKLQKEQKIKEHATTVNELEELQVQLQKEKKQLQKTMQELELVKKDAQQTTLM 1158
Query: 497 DLQ----ENYIEALN-KLVSENQQLQKDLMNTKSQLEISTQMCKKQNDRIFKPTHS-RTT 550
+++ E ++ LN KL ++N +++ + + +++I Q + + I S +
Sbjct: 1159 NMEIADYERLMKELNQKLTNKNNKIE----DLEQEIKIQKQKQETLQEEITSLQSSVQQY 1214
Query: 551 EFKNTEFKPTHGQHRHDGIKTEHYKTDLHSPRGQASDSINPMSRVLSPLSPQISPCSSTR 610
E KNT+ K + + + ++ +TD + + + + Q++ +S +
Sbjct: 1215 EEKNTKIKQLLVKTKKELADSKQAETDHLILQASLKGELEASQQQVEVYKIQLAEITSEK 1274
Query: 611 SLTSYSLCKTHSLPSALDTNEANFSDTMSESMNDQEEFISSCSLPVSPLGSIATRFLEEE 670
H + L T+ T+S C + ++ + F E
Sbjct: 1275 ----------HKIHEHLKTSAEQHQRTLSAYQQRVTALQEECRAAKAEQATVTSEF-ESY 1323
Query: 671 ELRSHHILER------LDAHIEELKRESE 693
++R H++L++ A E K+E E
Sbjct: 1324 KVRVHNVLKQQKNKSMSQAETEGAKQERE 1352
Score = 88.2 bits (217), Expect = 2e-17
Identities = 131/549 (23%), Positives = 235/549 (42%), Gaps = 105/549 (19%)
Query: 58 EQELKSLRSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKL 117
E+++ L+ QLD T E + V + + I + + Y++ + L EEL LK +++
Sbjct: 195 EEQILYLQKQLDATTDEK---KETVTQLQNIIEANSQHYQKNINSLQEELLQLKAIHQEE 251
Query: 118 QKKQMREFRGNTKNHREDRSEIERLTAKI-------EEFRQKSLDWEKQRL--------- 161
K+ M + + K H + +++ L + E+ QK + E + L
Sbjct: 252 VKELMCQIEASAKEHEAEINKLNELKENLVKQCEASEKNIQKKYECELENLRKATSNANQ 311
Query: 162 -----------------IYQQQVSSLEAQRKALAEQSEIIQAQLV---NRKQKLESVELS 201
+ ++V LE K L Q I++ ++ N K KLE
Sbjct: 312 DNQICSILLQENTFVEQVVNEKVKHLEDTLKELESQHSILKDEVTYMNNLKLKLEMDAQH 371
Query: 202 SQSEIQHLSSKLE-RANDTICANELE---IERLTMRVNDL----------VGTSMTVLQE 247
+ E H LE + N+ + A E + IE+L + L + L+E
Sbjct: 372 IKDEFFHEREDLEFKINELLLAKEEQGCVIEKLKSELAGLNKQFCYTVEQHNREVQSLKE 431
Query: 248 QQQKEEK------LRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATN 301
Q QKE L +SEK L E + LK ++ + EA + E L+E ++
Sbjct: 432 QHQKEISELNETFLSDSEKEKLTLMFEIQGLKEQCENLQQEKQEAILNYESLREIMEILQ 491
Query: 302 TQHAVEAIRPREESLAEKKYTSQGQGDLDSVLSQLNFTHTSEDLLQAEVTCLEGSLESVS 361
T+ A + +E + K+ Q D+ + +L T +D L V L+G E +
Sbjct: 492 TELGESAGKISQEFESMKQ---QQASDVHELQQKLRTAFTEKDALLETVNRLQGENEKLL 548
Query: 362 ATCKQLSQELMEKYEE-LKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHL 420
+ QEL+ + E +K ++ N Y + + + + LEG +I+ L
Sbjct: 549 S-----QQELVPELENTIKNLQEKNGVYLLSLSQRDTMLKE--------LEG---KINSL 592
Query: 421 TQELHQRDITIASTKGSSSDM---------EKRLRAEMQKAEDKAVEHKEILDQL----- 466
T+E +D I K S +M E+RL E+ K ++ +++ L+Q
Sbjct: 593 TEE---KDDFINKLKNSHEEMDNFHKKCEREERLILELGKKVEQTIQYNSELEQKVNELT 649
Query: 467 ----ESLKLENRH---LSEMVMKLELGLHEAKEISLADLQENYIEALNKLVSENQQLQKD 519
E+LK ++++ L ++++++++ L E KE+ A+++ Y E NKL SE +QL +D
Sbjct: 650 GGLEETLKEKDQNDQKLEKLMVQMKV-LSEDKEVLSAEVKSLY-EENNKLSSEKKQLSRD 707
Query: 520 LMNTKSQLE 528
L SQ E
Sbjct: 708 LEVFLSQKE 716
Score = 73.9 bits (180), Expect = 5e-13
Identities = 109/471 (23%), Positives = 200/471 (42%), Gaps = 93/471 (19%)
Query: 23 AELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQV 82
A+ + LMK+++ + +K ++ E LE +KI++Q+ ++L+ ++ V Q
Sbjct: 1163 ADYERLMKELNQKLTNKNNKIED----LEQEIKIQKQKQETLQEEITSLQSSV---QQYE 1215
Query: 83 EEHEKIKQEMTMEYKQEL---KKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDRSEI 139
E++ KIKQ + ++ K+EL K+ + IL+ S K ++ + + ++ +EI
Sbjct: 1216 EKNTKIKQ-LLVKTKKELADSKQAETDHLILQASL----KGELEASQQQVEVYKIQLAEI 1270
Query: 140 ERLTAKIEEFRQKSLDWEKQRL-IYQQQVSSLEAQ-RKALAEQSEII------------- 184
KI E + S + ++ L YQQ+V++L+ + R A AEQ+ +
Sbjct: 1271 TSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEECRAAKAEQATVTSEFESYKVRVHNV 1330
Query: 185 ----------QAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRV 234
QA+ KQ+ E +E+ I L KL+ + + + N E++ L
Sbjct: 1331 LKQQKNKSMSQAETEGAKQEREHLEML----IDQLKIKLQDSQNNLQINVSELQTLQSEH 1386
Query: 235 NDLVGTSMTVLQEQQQKEEKLRE------SEKLL-------------------------- 262
+ L+ +LQE KE +LRE SE ++
Sbjct: 1387 DTLLERHNKMLQETVSKEAELREKLCSIQSENMMMKSEHTQTVSQLTSQNEVLRNSFRDQ 1446
Query: 263 -EALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAIRPREES---LAE 318
LQEE R+ LQ Q + + Q + ++Q +++ +R R + L +
Sbjct: 1447 VRHLQEEHRKTVETLQQQLSKMEAQLFQLKNEPTTRSPVSSQQSLKNLRERRNTDLPLLD 1506
Query: 319 KKYTSQGQG------DLDSVLSQLNFTHTSEDLLQAEVTCLEGSLESVSATCKQLSQELM 372
++ +G D +SV S +T + E LL + T LE L T ++L Q+L
Sbjct: 1507 MHTVTREEGEGMETTDTESVSSASTYTQSLEQLLNSPETKLEPPLWHAEFTKEELVQKLS 1566
Query: 373 EKYEE-------LKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKME 416
+ L+ EA N +IK LK +I + E++ +E
Sbjct: 1567 STTKSADHLNGLLRETEATNAILMEQIKLLKSEIRRLERNQEREKSAANLE 1617
Score = 72.4 bits (176), Expect = 1e-12
Identities = 110/547 (20%), Positives = 233/547 (42%), Gaps = 76/547 (13%)
Query: 37 AHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEY 96
AHK+ E + E ++ + EL ++RS+ ++ L +Q+EE + E++ +
Sbjct: 116 AHKELEQSHINYVKE--IENLKNELMAVRSKYS---EDKANLQKQLEEAMNTQLELSEQL 170
Query: 97 K------QELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDRSEIERLTAKIEEFR 150
K +KKL EE+ ++ +E+ ++ T +E ++++ + +
Sbjct: 171 KFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQKQLDATTDEKKETVTQLQNIIEANSQHY 230
Query: 151 QKSLDWEKQRL-----IYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKL--------ES 197
QK+++ ++ L I+Q++V L Q +A A++ E +L K+ L ++
Sbjct: 231 QKNINSLQEELLQLKAIHQEEVKELMCQIEASAKEHEAEINKLNELKENLVKQCEASEKN 290
Query: 198 VELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRE 257
++ + E+++L AN + +I + ++ N V V ++ + E+ L+E
Sbjct: 291 IQKKYECELENLRKATSNAN-----QDNQICSILLQENTFV--EQVVNEKVKHLEDTLKE 343
Query: 258 SEKLLEALQEE-----KRELKAALQSQ---ENLIHEARIQKEKLQEKVKATNTQHAVEAI 309
E L++E +LK + +Q + HE + K+ E + A Q V
Sbjct: 344 LESQHSILKDEVTYMNNLKLKLEMDAQHIKDEFFHEREDLEFKINELLLAKEEQGCVIEK 403
Query: 310 RPREESLAEKKY---TSQGQGDLDSV-------LSQLNFTHTSEDLLQAEVTCLEGSLES 359
E + K++ Q ++ S+ +S+LN T S+ + E L ++
Sbjct: 404 LKSELAGLNKQFCYTVEQHNREVQSLKEQHQKEISELNETFLSDS--EKEKLTLMFEIQG 461
Query: 360 VSATCKQLSQELME---KYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKME 416
+ C+ L QE E YE L+ + ++ L+ ++ + S E MK +
Sbjct: 462 LKEQCENLQQEKQEAILNYESLREI----------MEILQTELGESAGKISQEFESMKQQ 511
Query: 417 ISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHL 476
+ EL Q+ T + K + + RL+ E +K + +E++ +LE+ ++N
Sbjct: 512 QASDVHELQQKLRTAFTEKDALLETVNRLQGE----NEKLLSQQELVPELEN-TIKNLQE 566
Query: 477 SEMVMKLELGLHEAKEISLADLQENYIEALNKLVSENQQLQKDLMNTKSQLEISTQMCKK 536
V L L ++ L +L+ +N L E L N+ +++ + C++
Sbjct: 567 KNGVYLLSL---SQRDTMLKELEGK----INSLTEEKDDFINKLKNSHEEMDNFHKKCER 619
Query: 537 QNDRIFK 543
+ I +
Sbjct: 620 EERLILE 626
Score = 68.9 bits (167), Expect = 1e-11
Identities = 139/718 (19%), Positives = 290/718 (40%), Gaps = 114/718 (15%)
Query: 74 EVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHR 133
E+ L +Q E ++ KQE + Y+ L E + IL+ + K +EF +
Sbjct: 458 EIQGLKEQCENLQQEKQEAILNYES----LREIMEILQTELGESAGKISQEFESMKQQQA 513
Query: 134 EDRSEIERLTAKIEEFRQKS--------LDWEKQRLIYQQQ-VSSLEAQRKALAEQSEII 184
D E+++ F +K L E ++L+ QQ+ V LE K L E++ +
Sbjct: 514 SDVHELQQKLRTA--FTEKDALLETVNRLQGENEKLLSQQELVPELENTIKNLQEKNGVY 571
Query: 185 QAQLVNRKQKLESVE-----------------LSSQSEIQHLSSKLERANDTICANELEI 227
L R L+ +E +S E+ + K ER I ++
Sbjct: 572 LLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEEMDNFHKKCEREERLILELGKKV 631
Query: 228 ER-------LTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQS-- 278
E+ L +VN+L G L+E+ Q ++KL + ++ L E+K L A ++S
Sbjct: 632 EQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSLY 691
Query: 279 ---------QENLIHEARI---QKEKLQEKVKATNTQHAVEAIRPREESLAEKKYTSQGQ 326
++ L + + QKE + K T + ++ + +++L + Q Q
Sbjct: 692 EENNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQLMVEEQDNLNKLLENEQVQ 751
Query: 327 ---------GDLDSVLSQLNFTHTSED---LLQAEVTCLEGSLESVSATCKQLSQELMEK 374
G L + S+++ +D +LQA L E Q ++++E
Sbjct: 752 KLFVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAKINEEKCNLAFQRDEKVLEL 811
Query: 375 YEELKRMEAHNNEYKAEIKKL-----KEQI-----LQGEQSYSSALEGMKMEISHLTQE- 423
+E+K ++ + E+K L +E++ L+ QS AL+ +E+ + ++
Sbjct: 812 EKEIKCLQEESVVQCEELKSLLRDYEQEKVLLRKELEEIQSEKEALQSDLLEMKNANEKT 871
Query: 424 -LHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMVMK 482
L +++ I + S + + + E +K K EH+ + LE +L +R +++K
Sbjct: 872 RLENQNLLIQVEEVSQTCSKSEIHNEKEKCFIK--EHENLKPLLEQKELRDRRAELILLK 929
Query: 483 LELGLHEAKEISLADLQENYIEALNKLVSENQQLQKDLMNTKSQLEISTQMCKKQNDRIF 542
L AK S+ + + ++ L + + ++ K+ +++++ KK+ D
Sbjct: 930 DSL----AKSPSVKNDPLSSVKELEEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSR 985
Query: 543 KPTHSRTTEFKNTEFKP----------THGQHRHDGIKTEHYK--TDLHSPRGQASDSIN 590
K T + E ++ + G + + E+ K L + +A++ +
Sbjct: 986 KETQTVKEELESLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKERANNFEH 1045
Query: 591 PMSRVLSPLSPQISPCSSTRSLTSYSLCKTHSLPSALDTNEANFSDTM-SESMNDQEEFI 649
+ + L C + S L + +L S E + +++M D+E
Sbjct: 1046 RIEDLTRQLRNSTLQCETINSDNEDLLARIETLQSNAKLLEVQILEVQRAKAMVDKE--- 1102
Query: 650 SSCSLPVSPLGSIATRFLEEEELRSH----HILERLDAHIEELKRESEKTVRQFTALK 703
A + +E++++ H + LE L +++ K++ +KT+++ +K
Sbjct: 1103 -----------LEAEKLQKEQKIKEHATTVNELEELQVQLQKEKKQLQKTMQELELVK 1149
Score = 50.4 bits (119), Expect = 5e-06
Identities = 90/489 (18%), Positives = 188/489 (38%), Gaps = 44/489 (8%)
Query: 231 TMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQ-----EEKRELKAALQSQENLIHE 285
T+ DL+ + + Q+ + + E EK +E L+ E ++ AL + + +
Sbjct: 24 TLPKEDLIKFAKKQMMLIQKAKSRCTELEKEIEELRSKPVTEGTGDIIKALTERLDALLL 83
Query: 286 ARIQKEKLQEKVKATNTQHAVEAIRPREESLAEKKYTSQGQGDLDSVLSQLNFTHTSEDL 345
+ + E+ +K N I+ ++E E T G + S +N+ E+L
Sbjct: 84 EKAETEQQCLSLKKEN-------IKMKQE--VEDSVTKMGDAHKELEQSHINYVKEIENL 134
Query: 346 LQAEVTCLEGSLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQS 405
+ E+ + A ++ +E M EL N + +KKL+E+I
Sbjct: 135 -KNELMAVRSKYSEDKANLQKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEI------ 187
Query: 406 YSSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQ 465
G + +I +L ++L D T K + + ++ + A Q + +E L Q
Sbjct: 188 -EKIRPGFEEQILYLQKQL---DATTDEKKETVTQLQNIIEANSQHYQKNINSLQEELLQ 243
Query: 466 LESLKLENRHLSEMVMKLELGL--HEAKEISLADLQENYI---EALNKLVSENQQLQ-KD 519
L+++ E + E++ ++E HEA+ L +L+EN + EA K + + + + ++
Sbjct: 244 LKAIHQE--EVKELMCQIEASAKEHEAEINKLNELKENLVKQCEASEKNIQKKYECELEN 301
Query: 520 LMNTKSQLEISTQMCK---KQNDRIFKPTHSRTTEFKNT--EFKPTHGQHRHDGIKTEHY 574
L S Q+C ++N + + + + ++T E + H + + +
Sbjct: 302 LRKATSNANQDNQICSILLQENTFVEQVVNEKVKHLEDTLKELESQHSILKDEVTYMNNL 361
Query: 575 KTDLHSPRGQASDSINPMSRVLSPLSPQISPCSSTRSLTSYSLCKTHSLPSALDTNEANF 634
K L D L ++ + C L S L F
Sbjct: 362 KLKLEMDAQHIKDEFFHEREDLEFKINELLLAKEEQG------CVIEKLKSELAGLNKQF 415
Query: 635 SDTMSESMNDQEEFISSCSLPVSPLGSIATRFLEEEELRSHHILERLDAHIEELKRESEK 694
T+ + + + +S L E+E+L ++ L E L++E ++
Sbjct: 416 CYTVEQHNREVQSLKEQHQKEISELNETFLSDSEKEKLTLMFEIQGLKEQCENLQQEKQE 475
Query: 695 TVRQFTALK 703
+ + +L+
Sbjct: 476 AILNYESLR 484
>gi|38044112 restin isoform b [Homo sapiens]
Length = 1392
Score = 96.3 bits (238), Expect = 9e-20
Identities = 148/759 (19%), Positives = 309/759 (40%), Gaps = 130/759 (17%)
Query: 42 EWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQVEEHEKIKQEM---TMEYKQ 98
E E + L T ++ ++E L +QL+ ++V L +VEE K ++ T+ K
Sbjct: 405 ELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLEVATVSEKS 464
Query: 99 ELKKLHEELCILKRSYEKLQKK-QMREFRGNTKNHREDRSEIERLTAKIEEFR---QKSL 154
+ +L ++L + + +L+++ + + G+ EI L K+E R Q+ +
Sbjct: 465 RIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREI 524
Query: 155 DWEKQRL-----IYQQQVSSLEAQRKALAEQSEIIQAQLVNR-----------KQKLESV 198
K+ +Q+++ +L + L++++E ++++L + K KLE+
Sbjct: 525 TSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETA 584
Query: 199 ELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRES 258
S Q ++ L + T A E++ ++ + LQ QQ E
Sbjct: 585 IASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAK 644
Query: 259 E------KLLEALQEEKRELKA--------------ALQSQENLIHEARIQKEKLQEKVK 298
E KL++ ++E++ L+A ++ N + EA I+ ++L+
Sbjct: 645 EMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQA 704
Query: 299 ATNTQHAV-----EAIRPREESL----AEKKYTSQGQGDLDSVLSQLNFTHTSEDLLQAE 349
N Q V ++ EE L A +K +S+G+ ++ + QL L+ E
Sbjct: 705 KCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIE 764
Query: 350 VTCLEGSLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSA 409
S++ + +L E L + + E++ LKE+ + + S
Sbjct: 765 KNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSV 824
Query: 410 LEGMKMEISHLTQELHQRDI---TIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILD-- 464
M+ ++ L Q+ Q ++ + + + +DME + R E + E++ ++ KE L+
Sbjct: 825 QRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFR-EKDEREEQLIKAKEKLEND 883
Query: 465 -------------QL----ESLKLENRHLSEMVMKLELGLHEAK--EISLADL----QEN 501
QL + L+L+ R + E+ +KL A + S+ D+ +++
Sbjct: 884 IAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQS 943
Query: 502 YIEALNKLVSENQQLQKDLMNTKSQLEISTQMCKKQNDRIFKPTHSRTTEFK-------- 553
EA K E ++L++ L + + ++E S C++ R + T T+ +
Sbjct: 944 QQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQK 1003
Query: 554 ---NTEFKPTHGQHRHDGIKTEHYKTDLHSPRGQASDSINPMSRVLSPLSPQISPCSSTR 610
+TE K + + G+ E + + + +A+ + +++ ++ +
Sbjct: 1004 TLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKE-------- 1055
Query: 611 SLTSYSLCKTHSLPSALDTNEANFS-----DTMSE-SMNDQEEFISSCSLPVSPLGSIAT 664
KT +L S DT + N DT+ E ++ + EE S L +
Sbjct: 1056 --------KTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKEL-------LTV 1100
Query: 665 RFLEEEELRSHHILERLDAHIEELKRESEKTVRQFTALK 703
+ EE R IE LK+ + + +Q +AL+
Sbjct: 1101 ENQKMEEFRK---------EIETLKQAAAQKSQQLSALQ 1130
Score = 88.6 bits (218), Expect = 2e-17
Identities = 153/723 (21%), Positives = 304/723 (42%), Gaps = 130/723 (17%)
Query: 23 AELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQV 82
AE EL QI+ M + E E + ++ +E+++LR++L + ++ ++
Sbjct: 608 AEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKL------MKVIKEKE 661
Query: 83 EEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDRSEIERL 142
E I+ ++ Q L ++ + L L+ + K+++ ++ + + N E I+
Sbjct: 662 NSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCN-----EQTKVIDNF 716
Query: 143 TAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAE-QSEI--IQAQLVNRKQKLESVE 199
T++++ +K LD L+A RKA +E +SE+ ++ QL +++++ +E
Sbjct: 717 TSQLKATEEKLLD--------------LDALRKASSEGKSEMKKLRQQLEAAEKQIKHLE 762
Query: 200 LSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESE 259
+ +E SSK + EL++ L ++++ T+ +E Q +EK E+
Sbjct: 763 IEKNAE----SSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEAS 818
Query: 260 KLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKV---------KATNTQHAVEAIR 310
+ ++Q +E L +E + EKL+E + K + ++A
Sbjct: 819 EEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKE 878
Query: 311 PREESLAE-KKYTSQGQGDLDSVLSQLNFTHTSEDLLQAEVT-------CLEGSLESVSA 362
E +AE K + L + +L + LQ ++T L+ S+E ++
Sbjct: 879 KLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTV 938
Query: 363 TCKQLSQELMEKYEE------------LKRMEAHNNEYK----------AEIKKLKEQIL 400
+Q QE +K+EE K+ME +N+ + +E K E+IL
Sbjct: 939 KAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEIL 998
Query: 401 QGEQ----SYSSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKA 456
Q Q L+G + E S L QEL E R +A+ KA A
Sbjct: 999 QNLQKTLLDTEDKLKGAREENSGLLQELE----------------ELRKQADKAKAAQTA 1042
Query: 457 VEHKEILDQLESLKLEN----RHLSEMVMKLELGLHEAKEISLADLQENYIEALNK---- 508
+ +I++Q+ K E + KL+ L KE +L +++E LNK
Sbjct: 1043 EDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEE-----LNKSKEL 1097
Query: 509 LVSENQQLQKDLMNTKSQLEISTQMCKKQNDRIFKPTHSRTTEFKNTEFKPTHGQHRHDG 568
L ENQ++++ + ++E Q +++ ++ + +N + G+ R +
Sbjct: 1098 LTVENQKMEE----FRKEIETLKQAAAQKSQQL------SALQEENVKLAEELGRSRDE- 1146
Query: 569 IKTEHYKTDLHSPRGQASDSINPMSRVLSPLSPQISPCSSTRSLTSYSLCKTHSLPSALD 628
T H K L R ++ + M + S I ++ SL K+ S+ SAL
Sbjct: 1147 -VTSHQK--LEEERSVLNNQLLEMKKRESKF---IKDADEEKA----SLQKSISITSALL 1196
Query: 629 TNEANFSDTMSESMNDQEEFISSCSLPVSPLGSIATRFLEEEELRSHHILERLDAHIEEL 688
T + D E + ++ + + L S+ + LE ++++ ++ L+ ++E
Sbjct: 1197 TEK----DAELEKLRNEVTVLRGENASAKSLHSV-VQTLESDKVKLELKVKNLELQLKEN 1251
Query: 689 KRE 691
KR+
Sbjct: 1252 KRQ 1254
Score = 68.2 bits (165), Expect = 3e-11
Identities = 104/530 (19%), Positives = 224/530 (42%), Gaps = 58/530 (10%)
Query: 57 REQELKSLRSQLDVTHKEVGMLH-------QQVEEHEKIKQEMTMEYKQELKKLHEELCI 109
RE++L + +L+ E+ + ++ + ++K+ E + +L K +E
Sbjct: 869 REEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASF 928
Query: 110 LKRSYEKLQKKQMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLD-WEKQRLIYQQQVS 168
L++S E + K + + K H E++ E+ER + +E+ + S + ++ + Y++ S
Sbjct: 929 LQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATS 988
Query: 169 SLEAQRKALAEQSEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELE-- 226
+ + + + + +Q L++ + KL+ + +Q L ++A+ A E
Sbjct: 989 ETKTKHEEILQN---LQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDA 1045
Query: 227 ---IERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLI 283
+E++T + ++ L++ +Q KL+ L+ L+E + L + L+
Sbjct: 1046 MQIMEQMTKEKTE----TLASLEDTKQTNAKLQNE---LDTLKENNLKNVEELNKSKELL 1098
Query: 284 HEARIQKEKLQEKVKATNTQHAVEAIRPREESLAEKKYTSQGQGDLDSVLSQLNFTHTSE 343
++ +K++E K T A + ++ S +++ L L + TS
Sbjct: 1099 ---TVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVK-----LAEELGRSRDEVTSH 1150
Query: 344 DLLQAEVTCLEGSL----ESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQ- 398
L+ E + L L + S K +E + + A E AE++KL+ +
Sbjct: 1151 QKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNEV 1210
Query: 399 -ILQGEQSYSSALEGM--KMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDK 455
+L+GE + + +L + +E + EL +++ + + + Q ED+
Sbjct: 1211 TVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDE 1270
Query: 456 AVEHKEILDQLESLKLE-NRHLSEMVMKLELGLHEAKEISLADLQENYIEALNKLVSENQ 514
+ +I D L S+ ++ R ++ MK+E+ +S A L N + LN S++Q
Sbjct: 1271 RAQESQI-DFLNSVIVDLQRKNQDLKMKVEM-------MSEAALNGNG-DDLNNYDSDDQ 1321
Query: 515 QLQKDLMNTKSQLEISTQMCKKQNDRIFKPTHSRTTEFKNTEFKPTHGQH 564
+ Q K +L C +D PT ++ +E P H H
Sbjct: 1322 EKQS---KKKPRLFCDICDCFDLHDTEDCPTQAQMSE------DPPHSTH 1362
Score = 40.0 bits (92), Expect = 0.007
Identities = 41/216 (18%), Positives = 97/216 (44%), Gaps = 11/216 (5%)
Query: 25 LQELMKQIDIMVAH--KKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQV 82
++EL K +++ K E+ L+ + Q+L +L+ + +E+G +V
Sbjct: 1088 VEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEV 1147
Query: 83 EEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDRSEIERL 142
H+K+++E ++ Q L+ E +K + E+ Q + + E +E+E+L
Sbjct: 1148 TSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQ-KSISITSALLTEKDAELEKL 1206
Query: 143 TAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLES----V 198
++ R ++ + + V +LE+ + L + + ++ QL K++L S
Sbjct: 1207 RNEVTVLRGENASAKSLHSV----VQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNT 1262
Query: 199 ELSSQSEIQHLSSKLERANDTICANELEIERLTMRV 234
+ + + + S+++ N I + + + L M+V
Sbjct: 1263 DTQADEDERAQESQIDFLNSVIVDLQRKNQDLKMKV 1298
>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
sapiens]
Length = 1935
Score = 95.9 bits (237), Expect = 1e-19
Identities = 157/734 (21%), Positives = 317/734 (43%), Gaps = 103/734 (14%)
Query: 23 AELQELMKQIDIMVAHKKSEWEGRTHALETCLKIRE---QELKSLRSQLD----VTHKEV 75
++LQ+ +K++ + + E E A K+R +EL+ + +L+ T ++
Sbjct: 1102 SQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQI 1161
Query: 76 GMLHQQVEEHEKIK---QEMTMEYKQE---LKKLH-EELCILKRSYEKLQK-KQMREFRG 127
M ++ E +K++ +E T++++ L+K H + + L + LQ+ KQ E
Sbjct: 1162 EMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLE--- 1218
Query: 128 NTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQ 187
K E + E++ +T+ +E+ + + EK + Q++ + ++ AE+++
Sbjct: 1219 --KEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMN----EHRSKAEETQRSVND 1272
Query: 188 LVNRKQKL--ESVELSSQ-SEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTV 244
L +++ KL E+ ELS Q E + L S+L R T T ++ DL
Sbjct: 1273 LTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTY----------TQQLEDL------- 1315
Query: 245 LQEQQQKEEKLRESEKLLEALQEEKRELKAAL-QSQENLIHEARIQK--EKLQEKVKATN 301
++Q EE+++ L ALQ + + Q +E +A +Q+ K +V
Sbjct: 1316 ---KRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWR 1372
Query: 302 TQHAVEAIRPREESLAEKKYTSQGQGDLDSVLSQLNFTHTS----EDLLQAEVTCLEGSL 357
T++ +AI+ EE KK +Q + + + +N +S + LQ E+ L +
Sbjct: 1373 TKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDV 1432
Query: 358 ESVSATCKQLSQ----------ELMEKYEELK-RMEAHNNEYKA---EIKKLK---EQIL 400
E +A L + E +KYEE + +E+ E ++ E+ KLK E+ L
Sbjct: 1433 ERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESL 1492
Query: 401 QGEQSYSSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKA---V 457
+ +++ + ++ EIS LT++L TI + +E + E+Q A ++A +
Sbjct: 1493 EHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAE-KMELQSALEEAEASL 1551
Query: 458 EHKE---ILDQLE--SLKLE-NRHLSEMVMKLELGLHEAKEISLADLQENYIEALNKLVS 511
EH+E + QLE +K E R L+E ++E + + + D + ++A + +
Sbjct: 1552 EHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQA--KRNHLRVVDSLQTSLDAETRSRN 1609
Query: 512 ENQQLQKDLMNTKSQLEISTQMCKKQNDRIFKPTHSRTTEFKNTEFKPTHGQHRHDGIKT 571
E +++K + +++EI + K S + K+T+ + +D +K
Sbjct: 1610 EALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKE 1669
Query: 572 EHYKTDLHSPRGQASDSINPMSRVLSPLSPQISPCSSTRSLTSYSLCKT-------HSLP 624
+ + N + L L + +R L L +T HS
Sbjct: 1670 NIAIVERRN---------NLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQN 1720
Query: 625 SALDTNEANFSDTMSESMNDQEEFISSC-SLPVSPLGSIATRFLEEEELRSHHILERLDA 683
++L + +S+ + EE + C + +I + EEL+ + A
Sbjct: 1721 TSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKE---QDTSA 1777
Query: 684 HIEELKRESEKTVR 697
H+E +K+ E+T++
Sbjct: 1778 HLERMKKNMEQTIK 1791
Score = 92.4 bits (228), Expect = 1e-18
Identities = 148/718 (20%), Positives = 289/718 (40%), Gaps = 116/718 (16%)
Query: 22 EAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQ 81
E ++ L+++ + + ++E + A E C +Q +K+ + QL+ KE ++++
Sbjct: 874 EEKMVSLLQEKNDLQLQVQAEQDNLADAEERC----DQLIKN-KIQLEAKVKE---MNER 925
Query: 82 VEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQ------KKQMREFRGNTKNHRED 135
+E+ E++ E+T + + KL +E LKR + L+ +K+ KN E+
Sbjct: 926 LEDEEEMNAELTAKKR----KLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEE 981
Query: 136 RSEIERLTAK-------IEEFRQKSLD-----------WEKQRLIYQQQVSSLEAQRKAL 177
+ ++ + AK ++E Q++LD K ++ +QQV LE
Sbjct: 982 MAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGS---- 1037
Query: 178 AEQSEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDL 237
EQ + ++ L K+KLE +Q I L + ++ ++ + + E+ L R+ D
Sbjct: 1038 LEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIED- 1096
Query: 238 VGTSMTVLQEQQQKEEKLRESEKLLEALQEE---KRELKAALQS-QENLIHEARIQKEKL 293
L Q QK KL+E + +E L+EE +R +A ++ + +L E E+L
Sbjct: 1097 ----EQALGSQLQK--KLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERL 1150
Query: 294 QEKVKATNTQHAVEAIRPREESLAEKKYTSQGQGDLDSVLSQLNFTHTSEDLLQAEVTCL 353
+E AT+ Q +E + RE + + DL+ E LQ E T
Sbjct: 1151 EEAGGATSVQ--IEMNKKREAEFQKMR------RDLE------------EATLQHEATAA 1190
Query: 354 EGSLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGM 413
+ + EL E+ + L+R++ + K+E
Sbjct: 1191 ALRKKHADSVA-----ELGEQIDNLQRVKQKLEKEKSE---------------------F 1224
Query: 414 KMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLEN 473
K+E+ +T + Q A+ + +E ++ KAE+ ++ Q L+ EN
Sbjct: 1225 KLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTEN 1284
Query: 474 RHLSEMVMKLELGLHEAKEISLADLQ---------ENYIEALNKLVSENQQLQKDLMNTK 524
LS + + E + + L Q E ++A N L Q + D +
Sbjct: 1285 GELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLR 1344
Query: 525 SQLEISTQMCKKQNDRIFKPTHSRTTEFKNTEFKPTHGQHRHDGIKTEHYKTDLHSPRGQ 584
Q E T+ K + R+ +S +++ T+++ Q + E K L +
Sbjct: 1345 EQYEEETE-AKAELQRVLSKANSEVAQWR-TKYETDAIQRTEE---LEEAKKKLAQRLQE 1399
Query: 585 ASDSINPMSRVLSPLSPQISPCSSTRSLTSYSLCKTHSLPSALDTNEANFSDTMSESMND 644
A +++ ++ S L + + ++++ +ALD + NF ++E
Sbjct: 1400 AEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQK 1459
Query: 645 QEEFISSCSLPVSPLGSIATRFLEEEELRSHHILERLDAHIEELKRESEKTVRQFTAL 702
EE S S++T E + + E H+E KRE++ + + L
Sbjct: 1460 YEESQSELESSQKEARSLST-----ELFKLKNAYEESLEHLETFKRENKNLQEEISDL 1512
Score = 90.9 bits (224), Expect = 4e-18
Identities = 128/616 (20%), Positives = 263/616 (42%), Gaps = 83/616 (13%)
Query: 3 ALLEGIQNRGHGGGFL-------TSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLK 55
AL +Q+ H L T +AELQ ++ + + VA ++++E T A++ +
Sbjct: 1328 ALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYE--TDAIQRTEE 1385
Query: 56 IREQELKSLRSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQ---ELKKLHEELCIL-- 110
+ E + K L +L + V ++ + EK K + E + ++++ + L
Sbjct: 1386 LEEAK-KKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDK 1444
Query: 111 -KRSYEKL-------QKKQMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLI 162
+R+++K+ ++ E + K R +E+ +L EE + ++++
Sbjct: 1445 KQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKN 1504
Query: 163 YQQQVSSLEAQRKALAE---QSEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDT 219
Q+++S L Q + + + E ++ QL K +L+S +++ ++H K+ RA
Sbjct: 1505 LQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLE 1564
Query: 220 ICANELEIERLT--------------MRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEAL 265
+ EIER +RV D + TS+ E + + E LR +K+
Sbjct: 1565 FNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDA--ETRSRNEALRVKKKM---- 1618
Query: 266 QEEKRELKAALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAIRPREESLAEKKYTSQG 325
+ + E++ L + EA+ Q + LQ +K T Q +A+R
Sbjct: 1619 EGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQ-LDDAVRAN------------- 1664
Query: 326 QGDLDSVLSQLNFTHTSEDLLQAEVTCLEGSLESVSATCKQLSQELMEKYEELKRMEAHN 385
D + + +LLQAE+ L +E + K QEL+E E ++ + + N
Sbjct: 1665 ----DDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQN 1720
Query: 386 ----NEYK---AEIKKLKEQILQGEQSYSSALEGMKMEISH---LTQELHQRDITIASTK 435
N+ K A++ +L+ ++ + Q +A E K I+ + +EL + T A +
Sbjct: 1721 TSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLE 1780
Query: 436 GSSSDME---KRLRAEMQKAEDKAVE-HKEILDQLESLKLENRHLSEMVMKLELGLHEAK 491
+ME K L+ + +AE A++ K+ L +LE+ E + E K A+
Sbjct: 1781 RMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELEAEQK-----RNAE 1835
Query: 492 EISLADLQENYIEALNKLVSENQQLQKDLMNTKSQLEISTQMCKKQNDRIFKPTHSRTTE 551
+ E I+ L E+++ L + +L++ + K+Q + + ++ ++
Sbjct: 1836 SVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSK 1895
Query: 552 FKNTEFKPTHGQHRHD 567
F+ + + + R D
Sbjct: 1896 FRKVQHELDEAEERAD 1911
Score = 31.6 bits (70), Expect = 2.6
Identities = 65/335 (19%), Positives = 125/335 (37%), Gaps = 52/335 (15%)
Query: 371 LMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHLTQELHQRDIT 430
L++ E K M + K E +LKE + + E E M L QE + +
Sbjct: 839 LLKSAEREKEMAS----MKEEFTRLKEALEKSEARRKELEEKMVS----LLQEKNDLQLQ 890
Query: 431 IASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMVMKLELGLHEA 490
+ + + + +D E+R ++ + KE+ ++LE + N L+ KLE E
Sbjct: 891 VQAEQDNLADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSEL 950
Query: 491 KEISLADLQENYIEALNKLVSENQQLQKDLMNTKSQL----EISTQMCKKQNDRIFKPTH 546
K + DL+ L K+ E + + N ++ EI ++ K++ + + H
Sbjct: 951 KR-DIDDLE----LTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEK--KALQEAH 1003
Query: 547 SRTTEFKNTEFKPTHGQHRHDGIKTEHYKTDLHSPRGQASDSINPMSRVLSPLSPQISPC 606
Q D ++ E D +N +++ L Q+
Sbjct: 1004 ----------------QQALDDLQAE-------------EDKVNTLTKAKVKLEQQVDDL 1034
Query: 607 SSTRSLTSYSLCKTHSLPSALDTNEANFSDTMSESMNDQEEFISSCSLPVSPLGSIATRF 666
+ L+ + +++ + ND+++ L ++ R
Sbjct: 1035 EGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARI 1094
Query: 667 LEEEELRS--HHILERLDAHIEELKR--ESEKTVR 697
+E+ L S L+ L A IEEL+ E+E+T R
Sbjct: 1095 EDEQALGSQLQKKLKELQARIEELEEELEAERTAR 1129
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 95.1 bits (235), Expect = 2e-19
Identities = 107/486 (22%), Positives = 225/486 (46%), Gaps = 46/486 (9%)
Query: 18 LTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGM 77
L+ + EL++ + + + + L ++ ++QEL L+ Q ++
Sbjct: 478 LSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQ---AKEKQAQ 534
Query: 78 LHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDRS 137
L Q +++ E+ Q + + +Q L K +++Q++E + R+D +
Sbjct: 535 LAQTLQQQEQASQGLRHQVEQLSSSL------------KQKEQQLKEVAEKQEATRQDHA 582
Query: 138 EIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLES 197
++L EE R+ SL ++R + LEA K A + EI+Q QL + +S
Sbjct: 583 --QQLATAAEE-REASL---RER---DAALKQLEALEKEKAAKLEILQQQLQVANEARDS 633
Query: 198 VELS---SQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEK 254
+ S +Q E LS K+E + E +V +L + Q+ +KE
Sbjct: 634 AQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERV 693
Query: 255 LRESEKL---LEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAIRP 311
+E ++L L+AL+E + K +L+ ++ +A ++++ ++KA T+ VE +
Sbjct: 694 AQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKA-ETRSLVEQHKR 752
Query: 312 REESLAEKKYTSQGQGDLDSVLSQLNFTHTSE-DLLQAEVTCLEGSLESVSATCKQLSQE 370
+ L E++ G+ L++ L QL H +E ++L+ E+ + + + C+QL +E
Sbjct: 753 ERKELEEER---AGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKE 809
Query: 371 L---MEKYEELKRMEA-HNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHLTQELHQ 426
+ E+YE+ ++ EA + ++ ++ LKE+ + Q A E + SH
Sbjct: 810 VAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESH------- 862
Query: 427 RDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMVMKLELG 486
++ I+ + +++ L +Q+ ++K V +++ D L +L+ + S+ V +LE
Sbjct: 863 SELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETL 922
Query: 487 LHEAKE 492
+ +A E
Sbjct: 923 VRKAGE 928
Score = 90.1 bits (222), Expect = 6e-18
Identities = 115/501 (22%), Positives = 225/501 (44%), Gaps = 65/501 (12%)
Query: 78 LHQQVEEHEKIKQEMTMEYKQELKK-----LHEELCILKRSYEKLQKK--QMREFRGNTK 130
L++ EEH K QE +E + +L+K L ++ C+ +++ E LQ K Q+ E +
Sbjct: 341 LNELTEEHSKATQEW-LEKQAQLEKELSAALQDKKCLEEKN-EILQGKLSQLEEHLSQLQ 398
Query: 131 -NHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQR-----KALAEQSEI- 183
N +++ E+ ++E +Q++ Q +V LE +R K LAE+
Sbjct: 399 DNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAERGHFE 458
Query: 184 ------------IQAQLVNRKQKLESVELSSQS-------EIQHLSSKLERANDTICANE 224
+Q+ + N Q E +E +SQ+ ++ L+S+L N TI +
Sbjct: 459 EEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQD 518
Query: 225 LEIERLTMRVNDLVGTSMTVLQEQQQKEEKLR-ESEKLLEALQEEKRELKAALQSQENLI 283
E+ L + + LQ+Q+Q + LR + E+L +L++++++LK + QE
Sbjct: 519 QELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQE--- 575
Query: 284 HEARIQKEKLQEKVKATNTQHAVEAIRPREESLAE-KKYTSQGQGDLDSVLSQLNFTHTS 342
+++ Q+ A + A ++R R+ +L + + + L+ + QL + +
Sbjct: 576 ---ATRQDHAQQLATAAEEREA--SLRERDAALKQLEALEKEKAAKLEILQQQLQVANEA 630
Query: 343 EDLLQAEVTCLEGSLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQG 402
D Q VT + +S ++L + E R E H E +A++ +L+ Q L+
Sbjct: 631 RDSAQTSVTQAQREKAELSRKVEEL-----QACVETARQEQH--EAQAQVAELELQ-LRS 682
Query: 403 EQSYSSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQ---------KAE 453
EQ ++ E + E L ++L ++ TKGS + ++R ++ KAE
Sbjct: 683 EQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAE 742
Query: 454 DKAV--EHKEILDQLESLKLENRHLSEMVMKLELGLHEAKEISLADLQENYIEALNKLVS 511
+++ +HK +LE + + L + +L E+ +L E + A + S
Sbjct: 743 TRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAE-AMAAQHTAES 801
Query: 512 ENQQLQKDLMNTKSQLEISTQ 532
E +QL K++ + + E S Q
Sbjct: 802 ECEQLVKEVAAWRERYEDSQQ 822
Score = 84.7 bits (208), Expect = 3e-16
Identities = 113/505 (22%), Positives = 223/505 (44%), Gaps = 78/505 (15%)
Query: 80 QQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKK--QMREFRGNTK-NHREDR 136
+++EE + +TM + LK+ + LK ++ +K Q+ E G+ RE
Sbjct: 276 KELEELRDKNESLTMRLHETLKQCQD----LKTEKSQMDRKINQLSEENGDLSFKLREFA 331
Query: 137 SEIERLTAKI----EEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRK 192
S +++L + EE + + +W +++ ++++S+ +K L E++EI+Q +L +
Sbjct: 332 SHLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLE 391
Query: 193 QKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKE 252
+ L ++ + E K E D + L+ E T+ N+ T + E + E
Sbjct: 392 EHLSQLQDNPPQE------KGEVLGDVLQLETLKQEAATLAANN---TQLQARVEMLETE 442
Query: 253 EKLRESEKLLEA--LQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATNTQHAVE--- 307
+E++ L E +EEK++L + + ++ I KE+L++ +A + +
Sbjct: 443 RGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVAS 502
Query: 308 ----------AIRPREESLAE-KKYTSQGQGDLDSVLSQ-----LNFTHTSEDL---LQA 348
I+ +++ LA K+ + Q L L Q H E L L+
Sbjct: 503 LTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQ 562
Query: 349 EVTCLEGSLESVSATCKQLSQELMEKYEE-----------LKRMEAHNNEYKAEIKKLKE 397
+ L+ E AT + +Q+L EE LK++EA E A+++ L++
Sbjct: 563 KEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQ 622
Query: 398 QILQGEQSYSSALEGM------KMEISHLTQELHQRDITIA-----STKGSSSDMEKRLR 446
Q+ ++ SA + K E+S +EL Q + A + +++E +LR
Sbjct: 623 QLQVANEARDSAQTSVTQAQREKAELSRKVEEL-QACVETARQEQHEAQAQVAELELQLR 681
Query: 447 AEMQKAEDK---AVEHKEILDQLESLKLENRHLSEMVMKLELGLHEAKEISLADLQENYI 503
+E QKA +K A E ++ +QL++LK +K+ G E ++ AD E
Sbjct: 682 SEQQKATEKERVAQEKDQLQEQLQALKES--------LKVTKGSLEEEKRRAADALEEQQ 733
Query: 504 EALNKLVSENQQLQKDLMNTKSQLE 528
+++L +E + L + + +LE
Sbjct: 734 RCISELKAETRSLVEQHKRERKELE 758
Score = 78.2 bits (191), Expect = 2e-14
Identities = 153/753 (20%), Positives = 300/753 (39%), Gaps = 104/753 (13%)
Query: 39 KKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQ 98
+K+E + L+ C++ QE ++Q+ ++ Q+ E E++ QE + ++
Sbjct: 644 EKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKD-QLQE 702
Query: 99 ELKKLHEELCILKRSYEKLQKK-------QMR-------EFRGNTKNHREDRSEIE--RL 142
+L+ L E L + K S E+ +++ Q R E R + H+ +R E+E R
Sbjct: 703 QLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEERA 762
Query: 143 TAKIEEFRQKSLDWEKQ---RLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESVE 199
K E R + L Q ++ ++ ++ AQ A +E ++++ R++ +S +
Sbjct: 763 GRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQ 822
Query: 200 LSSQ-------------SEIQHLSSKLERANDTICA----NELEIERLTMRVNDLVGTSM 242
+Q E + +L+ A + + +EL+I R + +L
Sbjct: 823 EEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQNELAELHANLA 882
Query: 243 TVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQ-----KEKLQEKV 297
LQ+ Q+KE + ++ L LQE+ + E L+ +A Q +E ++E
Sbjct: 883 RALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPA 942
Query: 298 KA----------------TNTQHAVEAIRPREESLAEK-------KYTSQGQGDLDSVLS 334
+A +TQ A++A+ E + + SQGQ +
Sbjct: 943 RAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEERGQQ 1002
Query: 335 QLNFTHTSED--LLQAEVTCLEGSLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEI 392
+ +++ QA++ + + + + E ++ L+ AH K E
Sbjct: 1003 EREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEK-EG 1061
Query: 393 KKLKEQILQG-EQSYSSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKR------- 444
K + L+G E + LE ++ + L ++L +++ AS G+ S+ R
Sbjct: 1062 KDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPK 1121
Query: 445 ---LRAEMQKAEDKAVEHKEILDQLE-SLKLENRHLSEMVMKLEL--GLHEAKEISLADL 498
LRAE+ K E + + +E D LE SL+ E +E LE G E K L
Sbjct: 1122 LEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHS 1181
Query: 499 QENYIEALNKLVSENQQLQ---KDLMNTKSQLEISTQMCKKQNDRIFKPTH-----SRTT 550
Q A +L + ++Q K K+Q+ Q +++N I +R
Sbjct: 1182 QSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQV 1241
Query: 551 EFKNTEFKPTHGQHRHDGIKTEHYKTDLHSPRGQASDSINPMSRVLSPLSPQISPCSSTR 610
K E K + K++ + L + + + + + S L ++ S R
Sbjct: 1242 LEKEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAAERSSALREEV---QSLR 1298
Query: 611 SLTSYSLCKTHSLPSALDTNEANFSDTMSESMNDQEE--FISSCSLPVSPLGSIATRFLE 668
+ +L L T++A ++ + + + +E F +L L +T+ L
Sbjct: 1299 EEAEKQRVASENLRQEL-TSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALV 1357
Query: 669 EEELRSHHILERLDA--------HIEELKRESE 693
E L + H+ ++L A H EEL++ +
Sbjct: 1358 SELLPAKHLCQQLQAEQAAAEKRHREELEQSKQ 1390
Score = 71.6 bits (174), Expect = 2e-12
Identities = 105/552 (19%), Positives = 232/552 (42%), Gaps = 56/552 (10%)
Query: 4 LLEGIQNRGHGGGFLTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKS 63
L E Q GH L S + EL ++ H K+E E + QE +
Sbjct: 1171 LEEKAQELGHSQSALASAQRELAAFRTKVQ---DHSKAEDEWKAQVARG-----RQEAER 1222
Query: 64 LRSQLDVTHKEVGMLHQQVEEHEKIKQEM---TMEYKQELKKLHEELCILK--------R 112
S + +EV +L++QV E E +E+ M ++ +KL E L +L+ R
Sbjct: 1223 KNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSAR 1282
Query: 113 SYEKLQ--KKQMREFRGNTKNHRED----RSEIERLTAKIEEFRQKSLDWEKQRLIYQQQ 166
+ E+ +++++ R + R R E+ + EE Q+ W+++ +Q
Sbjct: 1283 AAERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQA 1342
Query: 167 VSSLEAQRKALAEQSEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELE 226
+S+L+ + + ++ + ++L+ K + ++ + + +LE++ E
Sbjct: 1343 LSTLQLEHTS----TQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAE 1398
Query: 227 IERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEA 286
+ R + +L+ V ++++ ++ E E L K+ + L A
Sbjct: 1399 LLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERA 1458
Query: 287 RIQKEKLQEKVKATNTQHAVEAIRPR---EESLAEKKYTSQGQGDLDSVLSQLNFTHTSE 343
+ ++ L+ ++ ++ E R E LAE + +Q V++ +
Sbjct: 1459 NLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQREAQSTARELEVMTA-KYEGAKV 1517
Query: 344 DLLQAEVTCLEGSLESVSATCKQLS---QELMEKYEELKRMEAHNNEY-KAEIKKLKEQI 399
+L+ E + + ++A +QL +E ++ EEL + A +++ K + +KLK
Sbjct: 1518 KVLE-ERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQ 1576
Query: 400 LQGEQSYSSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAED----K 455
QG +S A + ++ +++ L +L Q++ + + +M+KA+ K
Sbjct: 1577 AQGGESQQEA-QRLQAQLNELQAQLSQKE-----------QAAEHYKLQMEKAKTHYDAK 1624
Query: 456 AVEHKEILDQLESLKLENRHLSEMVMKLELGLHEAKEISLADLQENYIEALNKLVSENQQ 515
+++E+ +QL SL+ + E+ + E HE ++ L + + L ++ +
Sbjct: 1625 KQQNQELQEQLRSLEQLQKENKELRAEAERLGHELQQAGLKTKEAE--QTCRHLTAQVRS 1682
Query: 516 LQKDLMNTKSQL 527
L+ + + QL
Sbjct: 1683 LEAQVAHADQQL 1694
Score = 67.4 bits (163), Expect = 4e-11
Identities = 98/452 (21%), Positives = 184/452 (40%), Gaps = 70/452 (15%)
Query: 121 QMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQ 180
QMR + + R +R E+E ++ E R+ + + Q + QQ++ L
Sbjct: 215 QMRRLKKQLADERSNRDELE---LELAENRKLLTEKDAQIAMMQQRIDRLA--------- 262
Query: 181 SEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGT 240
L+N KQ +E E++ L K E LTMR+++ +
Sbjct: 263 -------LLNEKQAASPLE---PKELEELRDKNES--------------LTMRLHETLKQ 298
Query: 241 SMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEK--VK 298
+ E+ Q + K+ + + L + RE + LQ ++ ++E + K ++ K
Sbjct: 299 CQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQLQDALNELTEEHSKATQEWLEK 358
Query: 299 ATNTQHAVEAIRPREESLAEKKYTSQGQ-GDLDSVLSQLNFTHTSE------DLLQAEVT 351
+ + A ++ L EK QG+ L+ LSQL E D+LQ E
Sbjct: 359 QAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETL 418
Query: 352 CLEGSLESVSATCKQLSQELMEK---YEELKRM--EAHNNEYKAEIKKL----------- 395
E + + + T Q E++E +E K + H E K ++ L
Sbjct: 419 KQEAATLAANNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNL 478
Query: 396 ---KEQILQGEQSYSSALEG----MKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAE 448
KE++ Q Q++ + L + E++ L + Q+D +A K + + + +L
Sbjct: 479 SQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQT 538
Query: 449 MQKAEDKAVEHKEILDQL-ESLKLENRHLSEMVMKLELGLHEAKEISLADLQENYIEALN 507
+Q+ E + + ++QL SLK + + L E+ K E + + LA E +L
Sbjct: 539 LQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQ-QLATAAEEREASLR 597
Query: 508 KLVSENQQLQKDLMNTKSQLEISTQMCKKQND 539
+ + +QL+ ++LEI Q + N+
Sbjct: 598 ERDAALKQLEALEKEKAAKLEILQQQLQVANE 629
Score = 63.2 bits (152), Expect = 8e-10
Identities = 83/389 (21%), Positives = 160/389 (41%), Gaps = 44/389 (11%)
Query: 66 SQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREF 125
S L + H L ++ + + Q++ E K+ EEL K++ L+ + +R
Sbjct: 1344 STLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQ 1403
Query: 126 RGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQ 185
R + E+ L K+ E + + ++ Y +Q+S L+ LAE++ +
Sbjct: 1404 R--------ELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLG 1455
Query: 186 AQLVNRKQKLESVELSSQSE--IQHLSSKLERANDTICANELEIERLTMRVNDLV----G 239
+ +Q LE VEL E +Q L++ A + + E + + + G
Sbjct: 1456 ERANLGRQFLE-VELDQAREKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEG 1514
Query: 240 TSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKA 299
+ VL+E+Q+ QEE+++L A ++ E E Q E+L +K+
Sbjct: 1515 AKVKVLEERQR--------------FQEERQKLTAQVEQLEVFQREQTKQVEELSKKLAD 1560
Query: 300 TNTQHAVEAIRPREESLAEKKYTSQGQGDLDSVLSQLNFTHTSEDLLQAEVTCLEGSLES 359
++ V+ +++ A + + Q + + +QLN L Q E L+
Sbjct: 1561 SDQASKVQ----QQKLKAVQAQGGESQQEAQRLQAQLN--ELQAQLSQKEQAAEHYKLQM 1614
Query: 360 VSATC-----KQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMK 414
A KQ +QEL E+ L++++ N E +AE ++L ++ Q A +
Sbjct: 1615 EKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHELQQAGLKTKEA----E 1670
Query: 415 MEISHLTQELHQRDITIASTKGSSSDMEK 443
HLT ++ + +A D+ K
Sbjct: 1671 QTCRHLTAQVRSLEAQVAHADQQLRDLGK 1699
Score = 60.1 bits (144), Expect = 7e-09
Identities = 89/382 (23%), Positives = 159/382 (41%), Gaps = 61/382 (15%)
Query: 9 QNRGHGGGF---LTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLR 65
Q++ GG L + EL EL I + K +E E L E S
Sbjct: 1387 QSKQAAGGLRAELLRAQRELGEL-----IPLRQKVAEQERTAQQLRA-------EKASYA 1434
Query: 66 SQLDVTHKEVGMLHQQV----EEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQ 121
QL + K G+L ++ E +Q + +E Q +K +EL ++ E +
Sbjct: 1435 EQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEV 1494
Query: 122 MREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQS 181
RE + + E+E +TAK E + K L+ E+QR +Q++ L AQ EQ
Sbjct: 1495 QREAQSTAR-------ELEVMTAKYEGAKVKVLE-ERQR--FQEERQKLTAQ----VEQL 1540
Query: 182 EIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDL---- 237
E+ Q + + ++L S + KL+ ++ E +RL ++N+L
Sbjct: 1541 EVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQL 1600
Query: 238 -------------VGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIH 284
+ + T ++Q+ ++L+E + LE LQ+E +EL+A E L H
Sbjct: 1601 SQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRA---EAERLGH 1657
Query: 285 EARIQKEKLQEKVKATNTQHAVEAIRPREESLAEKKYTSQGQGDLDSVLSQLNFTHTSED 344
E +Q+ L+ K +H +R E +A + Q DL + + E
Sbjct: 1658 E--LQQAGLKTKEAEQTCRHLTAQVRSLEAQVA---HADQQLRDLGKFQVATDALKSREP 1712
Query: 345 LLQAEVTCLEGSLESVSATCKQ 366
+ + L+ S++S+ +C++
Sbjct: 1713 QAKPQ---LDLSIDSLDLSCEE 1731
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 94.7 bits (234), Expect = 3e-19
Identities = 139/640 (21%), Positives = 280/640 (43%), Gaps = 117/640 (18%)
Query: 21 CEAELQELMKQIDIMV-AH--------------KKSEWEGRTHALETCLKIR---EQELK 62
CE E + L+K +I+ AH K++E E + L LK R E+EL
Sbjct: 649 CEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELS 708
Query: 63 SLRSQLDVTHKEV-GMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQK-- 119
L+ Q D +E+ + +Q H++ + E++ +++ + L E L K
Sbjct: 709 VLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKER 768
Query: 120 -KQMREFRGNTKNHRED----RSEIERLTAKIEEFR---------------------QKS 153
K ++E + + +N D E+++ +AK++ F+ QK
Sbjct: 769 DKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKL 828
Query: 154 LDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESVELSSQSEIQHLS--- 210
LD E +R++ +QV+ +EAQ+K + + + + Q+ + Q+LE + +++ L+
Sbjct: 829 LDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVY 888
Query: 211 -SKLERANDTICANE---LEIERLTMRVNDLVGTSMTVLQEQ------------QQKEEK 254
SKLE N + +E E + +++ + + +L ++ ++ E K
Sbjct: 889 ESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETK 948
Query: 255 LRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAIRPREE 314
+ EK +E ++++ +E+ QE L + Q+ KL+++++ T + + + + +
Sbjct: 949 FKNQEKKMEKVKQKAKEM------QETLKKKLLDQEAKLKKELENTALELSQKEKQFNAK 1002
Query: 315 SLAEKKYTSQGQGDLDSVLSQLNFTHTSEDLLQAEVTCLEGSLESVSATCKQLSQELMEK 374
L + S G D S L + N E L + L + Q ++EL E
Sbjct: 1003 MLEMAQANSAGISDAVSRL-ETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEI 1061
Query: 375 YEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHLTQELHQRDITI--- 431
+ E E + E+ +LK++IL + E M EI+ L +E ++D T+
Sbjct: 1062 H------EIQLQEKEQEVAELKQKIL----LFGCEKEEMNKEITWLKEEGVKQDTTLNEL 1111
Query: 432 -------ASTKGSSSDMEKRLRAEMQKAE---DKAVEHKEIL-DQLESLKL----ENRHL 476
++ S + E +L+A ++K E +K+++ L +QL LK+ + R +
Sbjct: 1112 QEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKV 1171
Query: 477 SEMVMKLEL------GLHEAKEISLADLQENYIEALNKLVSENQQLQKDLMNTKSQLEIS 530
SE+ KL+ L + E S L++ +E K +SE +Q D+ K++
Sbjct: 1172 SELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEF--KKLSEELAIQLDICCKKTE---- 1225
Query: 531 TQMCKKQNDRIFKPTHSRTTEFKNTEFKPTHGQHRHDGIK 570
+ + + + + + S+T + + +H QHR +K
Sbjct: 1226 -ALLEAKTNELINISSSKTNAILS---RISHCQHRTTKVK 1261
Score = 83.2 bits (204), Expect = 8e-16
Identities = 165/836 (19%), Positives = 337/836 (40%), Gaps = 155/836 (18%)
Query: 5 LEGIQNR-GHGGGFLTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIRE----- 58
LE +Q R L C+ +Q +Q ++ + K++ E L+ KI++
Sbjct: 281 LETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAE 340
Query: 59 -----QELKSLRSQLDVTHKEVGML----HQQVEEHEKIKQEMTMEYKQELKKLHEELCI 109
+L+ ++ ++ ++ GM+ +Q+ E ++K+E + + +K++ +
Sbjct: 341 KTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEE 400
Query: 110 LKRSYEKLQKKQMREFRGNTKNHREDRSEIERLTAKI-EEFRQKSLDWEKQRLIYQQQVS 168
L+ EK ++ E ++ +L A++ E+ + E++R+ QQ++S
Sbjct: 401 LREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELS 460
Query: 169 SL---------EAQRKALAEQSEIIQAQLVNRKQKLESVELSSQSEIQH---------LS 210
+ ++ + +A+ ++ + +L ++Q+L + + E Q S
Sbjct: 461 RVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQS 520
Query: 211 SKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLR----ESEKLLE-AL 265
L+ + + L +E L ++ ++ S L++ QQ+ E R E E LE +L
Sbjct: 521 EYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSL 580
Query: 266 QEEK---RELKAALQSQEN--------LIHEARIQKEKLQ--------EKVKATNTQHAV 306
QE K ++L L++++N ++ + + + E L+ EK++ Q+
Sbjct: 581 QENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQT 640
Query: 307 EAIRPREESLAEKK---------YTSQGQGDLDSVLSQLNFTHTSEDLLQAEVT------ 351
E + RE+ EK+ + + + + L +L+ T + L +E++
Sbjct: 641 EMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKAR 700
Query: 352 -CLEGSLESVSATCKQLSQELMEKYEELKR---------MEAHNNEYKAEIKKLKEQILQ 401
LE L + ++ QEL K +E K ++ H + K LK+QI Q
Sbjct: 701 HKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQ 760
Query: 402 GE----------QSYSSALEGMKMEISHLTQELHQRDITI-------ASTKGSSSDMEKR 444
E + + + +E ++ +I EL Q + ++T + E++
Sbjct: 761 LELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQ 820
Query: 445 LRAEMQKAEDKAVEH--------------KEILDQLESLKLENRHLSEMVMKLELGLHEA 490
L QK D E K++ +L++ K++ + L + + K + E
Sbjct: 821 LAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEM-EQ 879
Query: 491 KEISLADLQENYIEALNKLVSENQQL--QKDLM------NTKSQLEISTQMCKKQNDRIF 542
K SL + E+ +E NK + +Q+ +K+ M K ++EI TQ + D I
Sbjct: 880 KVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIH 939
Query: 543 KPTHSRTTEFKNTEFKPTHGQHRHDGIKTEHYKTDLHSPRGQASDSINPMSRVLSPLSPQ 602
T+FKN E K + + ++ E K L + + + LS Q
Sbjct: 940 ILNEEYETKFKNQEKKMEKVKQKAKEMQ-ETLKKKLLDQEAKLKKELENTALELSQKEKQ 998
Query: 603 ISPCSSTRSLTSYSLCKTHSLPSALDTNEANFSDTMSESMNDQEEFISSCS----LPVSP 658
+ + N A SD +S +Q+E I S + ++
Sbjct: 999 FNA----------------KMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELND 1042
Query: 659 LGSIATRFLEE--EELRSHH--ILERLDAHIEELKR-------ESEKTVRQFTALK 703
+ SI + L + EEL+ H L+ + + ELK+ E E+ ++ T LK
Sbjct: 1043 VISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLK 1098
Score = 82.8 bits (203), Expect = 1e-15
Identities = 122/569 (21%), Positives = 242/569 (42%), Gaps = 84/569 (14%)
Query: 29 MKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQVEEHEKI 88
++Q+D ++K SEW+ + + T + +K L+ QL++ KE +++ E+ +
Sbjct: 1432 LEQVDDW-SNKFSEWKKKAQSRFTQ---HQNTVKELQIQLELKSKEA---YEKDEQINLL 1484
Query: 89 KQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDRSEIERLTAKIEE 148
K+E+ + K+ L E+ K EK + E + T E I + T +IE
Sbjct: 1485 KEELDQQNKR-FDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIES 1543
Query: 149 FRQKSLDWEKQRLI-YQQQVSSL---------------EAQRKALAEQSEI--IQAQLVN 190
+ ++ +Q+ I +++ V L EA+ K L ++++ ++A+L
Sbjct: 1544 LNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELET 1603
Query: 191 RKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQ 250
+K++LE V LS +S+ + L + +R A E++R + + +L + ++
Sbjct: 1604 KKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQ--KIAAIKKQLLSQMEE 1661
Query: 251 KEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAIR 310
KEE+ ++ + EL LQ +E +H L+EK+K+ + + I
Sbjct: 1662 KEEQYKKGT------ESHLSELNTKLQEREREVHI-------LEEKLKSVESSQSETLIV 1708
Query: 311 PREESLAEKKYTSQGQGDLDSVLSQLNFTHTSEDLLQAEVTCLEGSLESVSATCKQLSQE 370
PR YT Q + D + + S +LQ +T E L+ V ++
Sbjct: 1709 PRSAKNVAA-YTEQEEADSQGCVQKTYEEKIS--VLQRNLTEKEKLLQRVGQEKEETVSS 1765
Query: 371 LME---KYEE----LKRMEAHNNEYKAEIKKLKEQILQGEQSYS---------------- 407
E +Y+E L+ EA +E ++ I L+E++ + + YS
Sbjct: 1766 HFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNI 1825
Query: 408 SALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRL-------RAEMQKAEDKAVEHK 460
A + ++ + + L ++++T + +++ L R EM++ K E
Sbjct: 1826 QAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSK-YEKL 1884
Query: 461 EILDQLESLKLENRHLSEMVM-KLELGLHEAKEISLADLQENYIE--------ALNKLVS 511
+ L Q++ L E K + L + K +S + Q N +E KL
Sbjct: 1885 QALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGK 1944
Query: 512 ENQQLQKDLMNTKSQLEISTQMCKKQNDR 540
E +LQKDL + + + ++ KK+ D+
Sbjct: 1945 EIVRLQKDLRMLRKEHQQELEILKKEYDQ 1973
Score = 73.6 bits (179), Expect = 6e-13
Identities = 117/581 (20%), Positives = 245/581 (42%), Gaps = 124/581 (21%)
Query: 41 SEWEGRTHALETCLKIREQELKSLRSQL----DVTHKEVGMLHQQVEEHEKIKQEMTMEY 96
S + G+ L T ++ ++E K L+ L D + + + L ++++ ++ K+ + E+
Sbjct: 151 SSYRGKYSELVTAYQMLQREKKKLQGILSQSQDKSLRRIAELREELQMDQQAKKHLQEEF 210
Query: 97 KQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDW 156
L++ + + +L+ L K+++R N + + + +L + E F ++
Sbjct: 211 DASLEEKDQYISVLQTQVSLL-KQRLR----NGPMNVDVLKPLPQLEPQAEVFTKEE--- 262
Query: 157 EKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERA 216
+ E+ + + E ++ LE++ Q ++ + L+R
Sbjct: 263 ------------NPESDGEPVVEDGTSVKT--------LETL----QQRVKRQENLLKRC 298
Query: 217 NDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAAL 276
+TI +++ + LT L Q+Q +E+L+E EK+ + EK +L L
Sbjct: 299 KETIQSHKEQCTLLTSEKEAL----------QEQLDERLQELEKIKDLHMAEKTKLITQL 348
Query: 277 QSQENLIHEARIQKEKLQEKVKATNTQHAVEAIRPREESLAE-----KKYTSQGQ----- 326
+ +NLI Q E+ + V A + E + +EE +A+ K+ T+QG+
Sbjct: 349 RDAKNLIE----QLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQ 404
Query: 327 ---------GDLDSVLSQLNFTHTSEDLLQAEVTCLEGSLESVSATCKQ----LSQELME 373
+L+ LS T + L+AE ++ ++++ T ++ L QEL
Sbjct: 405 KEKSERAAFEELEKALSTAQKTEEARRKLKAE---MDEQIKTIEKTSEEERISLQQELSR 461
Query: 374 -KYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHLTQELHQRDITIA 432
K E + M+ + E A+++KL E+ L ++ LT++L R+
Sbjct: 462 VKQEVVDVMKKSSEEQIAKLQKLHEKELARKE-------------QELTKKLQTRE---- 504
Query: 433 STKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMVMKLELGLHEAKE 492
+ +++++ ++K++ + ++ + +Q ESL LE L + + E E
Sbjct: 505 ------REFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTE------SE 552
Query: 493 ISLADLQENYIEALNKLVSENQQLQKDLMNTKSQ---LEISTQMCK-KQNDRIFKPTHSR 548
L DLQ+ +++ L+K L K+Q L + + K K N I
Sbjct: 553 NKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKH 612
Query: 549 TTEFKNTEFKPTHGQHRHDGIKTE-------HYKTDLHSPR 582
TE ++ +H+ D + TE Y+T++ R
Sbjct: 613 KTELESL-------KHQQDALWTEKLQVLKQQYQTEMEKLR 646
Score = 70.1 bits (170), Expect = 7e-12
Identities = 139/692 (20%), Positives = 272/692 (39%), Gaps = 140/692 (20%)
Query: 18 LTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSL----RSQLDVTHK 73
LT AE++ K + + K + + LE EQ++KSL S+L+ +K
Sbjct: 838 LTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNK 897
Query: 74 EVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELC-------ILKRSYE---KLQKKQMR 123
E Q + E E + +M K+E++ L ++L IL YE K Q+K+M
Sbjct: 898 EQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKME 957
Query: 124 EFRGNTKNHRED------------RSEIE----RLTAKIEEFRQKSLDW----------- 156
+ + K +E + E+E L+ K ++F K L+
Sbjct: 958 KVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDA 1017
Query: 157 -EKQRLIYQQQVSSL-EAQRKALAEQSEIIQAQLVNRKQKLESVE----LSSQSEIQHLS 210
+ ++Q+ SL E R+ L + I + +L + ++L+ + + E+ L
Sbjct: 1018 VSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELK 1077
Query: 211 SKL-------------------ERANDTICANEL--EIERLTMRVNDLVGTSMTVLQEQQ 249
K+ E NEL ++++ + VN L + +
Sbjct: 1078 QKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLE 1137
Query: 250 QKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAI 309
+ E L +S K LQE+ ELK + + + E + + E+ ++ + H
Sbjct: 1138 KLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNK 1197
Query: 310 RPREESLAEKKYTSQGQGDLD--------------------------SVLSQLNF----- 338
++SL KK + + LD ++LS+++
Sbjct: 1198 SLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRT 1257
Query: 339 THTSEDLL---------QAEVTCLEGSLESVSATCKQLSQELMEKYEELKRMEAHNNEYK 389
T E LL +A++ L +++ + +Q + +L EK ++K M+A
Sbjct: 1258 TKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLV 1317
Query: 390 AEIKKLKEQILQGEQSYS---SALEGMKMEISH-------LTQELHQRDITIASTKGSSS 439
E + L+++ +Q+ S S + +K E+S + +EL ++ + I+S +
Sbjct: 1318 TEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLT 1377
Query: 440 DMEKRLRAEMQKAEDKAV----------EHKEILDQLESLKLENRHLS-EMVMKLELGLH 488
D+ +L+ + +E +A E E+LDQ++ L + LS E + LE
Sbjct: 1378 DLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALE---- 1433
Query: 489 EAKEISLADLQENYIEALNKLVSENQQLQKDLMNTKSQLEISTQMCKKQNDRIFKPTHSR 548
+ D + E K S Q Q + + QLE+ ++ +++++I
Sbjct: 1434 -----QVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQI--NLLKE 1486
Query: 549 TTEFKNTEFKPTHGQHRHDGIKTEHYKTDLHS 580
+ +N F G+ D K E +++L +
Sbjct: 1487 ELDQQNKRFDCLKGEMEDDKSKMEKKESNLET 1518
Score = 70.1 bits (170), Expect = 7e-12
Identities = 98/486 (20%), Positives = 212/486 (43%), Gaps = 55/486 (11%)
Query: 18 LTSCEAELQELMKQIDIMVAHKKSEWEGRTHAL------ETCLKIREQELKSLRSQLDVT 71
L+ +LQE +++ I+ KS ++ L + EQE + + T
Sbjct: 1674 LSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKT 1733
Query: 72 HKE-VGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTK 130
++E + +L + + E EK+ Q + E ++ + E C + KL+ + ++
Sbjct: 1734 YEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQ------ 1787
Query: 131 NHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVN 190
ED+S I L ++EE +K LI Q V + A+Q+ ++ +
Sbjct: 1788 --HEDQSMIGHLQEELEEKNKK------YSLIVAQHVEKEGGKNNIQAKQN--LENVFDD 1837
Query: 191 RKQKLESVELSSQ---SEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMT---- 243
++ L+ EL+ Q +I+ L S L R + + +E+E LT + L
Sbjct: 1838 VQKTLQEKELTCQILEQKIKELDSCLVRQKEV---HRVEMEELTSKYEKLQALQQMDGRN 1894
Query: 244 ----VLQEQQQKEEKLRESE-KLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVK 298
+L+E +++ K + KLL ++ + +L+ L E + + +LQ+ ++
Sbjct: 1895 KPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLR 1954
Query: 299 ATNTQHAVEA-IRPREESLAEKKYTSQGQGDLD----SVLSQLNFTHTSEDLLQAEVTCL 353
+H E I +E ++ Q Q DL+ S L QL + L Q E L
Sbjct: 1955 MLRKEHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQL-MREFNTQLAQKEQE-L 2012
Query: 354 EGSLESVSATCKQLSQELMEKYEE-----LKRMEAHNNEYKAEIKKLKEQILQGEQSYSS 408
E +++ +++ EL+E ++E LK++ +++ K K+ +E + E+ ++
Sbjct: 2013 EMTIKETINKAQEVEAELLESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTA 2072
Query: 409 ALEGMKMEISHLTQELHQRDITIASTKGSSS----DMEKRLRAEMQKAEDKAVEHKEILD 464
+ ++ ++ L Q+ +Q+ + G+ + +++ +L + D ++ +E +
Sbjct: 2073 KVRDLQTQLEEL-QKKYQQKLEQEENPGNDNVTIMELQTQLAQKTTLISDSKLKEQEFRE 2131
Query: 465 QLESLK 470
Q+ +L+
Sbjct: 2132 QIHNLE 2137
Score = 68.6 bits (166), Expect = 2e-11
Identities = 126/648 (19%), Positives = 273/648 (42%), Gaps = 123/648 (18%)
Query: 18 LTSCEAELQELMKQIDIMVAHKKSEWEGRTHALE---TCLKIREQELKSLRSQLDVTHKE 74
++ EA+L++L ++ + + ++ TH LE +K + +++SL ++ + KE
Sbjct: 1271 VSELEAQLRQLTEEQNTL----NISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKE 1326
Query: 75 VGMLHQQVEEHE----KIKQEMTMEY------KQELKKLHEELCILKRSYEKLQ------ 118
G Q E E ++K+E++ K+ELK+ E+ L + L
Sbjct: 1327 GGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNS 1386
Query: 119 ---KKQMREFRGNTKNHREDRSEI----------------ERLTA--KIEEFRQKSLDWE 157
++ K + E++ E+ E+++A +++++ K +W+
Sbjct: 1387 ISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWK 1446
Query: 158 KQ-------------RLIYQQQVSSLEAQRK---------ALAEQS---EIIQAQLVNRK 192
K+ L Q ++ S EA K L +Q+ + ++ ++ + K
Sbjct: 1447 KKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDK 1506
Query: 193 QKLESVELSSQSEIQHLSSKLERANDTICANELEIERLT-----------MRVNDLVGTS 241
K+E E + ++E++ ++++ D I +EIE L + +LV
Sbjct: 1507 SKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKL 1566
Query: 242 MTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKA-- 299
+ ++K+ +++E+E+ + L+ + +KA L++++ + + + +E++KA
Sbjct: 1567 QHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALE 1626
Query: 300 ---------------TNTQHAVEAIRPREESLAEKKYTSQGQGDLDSVLSQLNFTHTSED 344
+ + AI+ + S E+K +G +S LS+LN T
Sbjct: 1627 DRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKG-TESHLSELN---TKLQ 1682
Query: 345 LLQAEVTCLEGSLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQ 404
+ EV LE L+SV ++ E + K + A+ + +A+ + ++ + +
Sbjct: 1683 EREREVHILEEKLKSVESS----QSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEK- 1737
Query: 405 SYSSALEGMKMEISHLTQELHQ-RDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEIL 463
S L+ E L Q + Q ++ T++S ++RL +++ AE K E + ++
Sbjct: 1738 --ISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERL-IKLEHAEAKQHEDQSMI 1794
Query: 464 DQL-ESLKLENRHLSEMVMKLELGLHEAKEISLADLQENYIEALNKLVSENQQLQKDLMN 522
L E L+ +N+ S +V + H KE +N I+A L + +QK L
Sbjct: 1795 GHLQEELEEKNKKYSLIVAQ-----HVEKEGG-----KNNIQAKQNLENVFDDVQKTLQE 1844
Query: 523 TKSQLEISTQMCKKQNDRIF--KPTHSRTTEFKNTEFKPTHGQHRHDG 568
+ +I Q K+ + + K H E ++++ + DG
Sbjct: 1845 KELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDG 1892
Score = 48.9 bits (115), Expect = 2e-05
Identities = 123/619 (19%), Positives = 239/619 (38%), Gaps = 69/619 (11%)
Query: 86 EKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDRSEIERLTAK 145
+K+KQ+++ E +Q L + L + S +MR R ++ + D R +
Sbjct: 3 KKLKQKISEEQQQ----LQQALAPAQASSNSSTPTRMRS-RTSSFTEQLDEGTPNRESGD 57
Query: 146 IEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESVELSSQSE 205
+ F QK Q +V S+E+ ++ ++S L K V SS+
Sbjct: 58 TQSFAQK----------LQLRVPSVESLFRSPIKES------LFRSSSKESLVRTSSRES 101
Query: 206 IQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEAL 265
+ L D+ A+ + DLVG S ++ +EQ ++LR E+ L +
Sbjct: 102 LNRLDL------DSSTASFDPPSDMDSEAEDLVGNSDSLNKEQLI--QRLRRMERSLSSY 153
Query: 266 QEEKRELKAALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAIRPREESLAEKKYTSQG 325
+ + EL A Q + +K+KLQ + + + REE +++
Sbjct: 154 RGKYSELVTAYQMLQR-------EKKKLQGILSQSQDKSLRRIAELREELQMDQQAKKHL 206
Query: 326 QGDLDSVLSQLNFTHTSEDLLQAEVTCLEGSLESVSATCKQLSQELMEKYEELK-RMEAH 384
Q + D+ L + + +LQ +V+ L+ L + ++ ++++ +L+ + E
Sbjct: 207 QEEFDASLEEKD---QYISVLQTQVSLLKQRLRN-----GPMNVDVLKPLPQLEPQAEVF 258
Query: 385 NNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKR 444
E E E +++ S + LE ++ + L + TI S K + +
Sbjct: 259 TKEENPESDG--EPVVEDGTSVKT-LETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSE 315
Query: 445 LRAEMQKAEDKAVEHKEILD--QLESLKL--ENRHLSEMVMKLELGLHEAKEISLADLQE 500
A ++ +++ E ++I D E KL + R ++ +LE + K + +A+ +
Sbjct: 316 KEALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLE----QDKGMVIAETKR 371
Query: 501 NYIEALNKLVSENQQLQKDLMNTKSQLEISTQMCKKQNDRIFKPTHSRTTEFKNTEFKPT 560
E L E QL+ + +Q E + +K F+ + + TE
Sbjct: 372 QMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTE---- 427
Query: 561 HGQHRHDGIKTEHYKTDLHSPRGQASDSINPMSRVLSPLSPQISPCSSTRSLTSYSLC-- 618
+ + E KT + + +SRV + + S + L
Sbjct: 428 EARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEK 487
Query: 619 ----KTHSLPSALDTNEANFSDTMSESMNDQEEFISSCSLPVSPLGSIATRFLEEEELRS 674
K L L T E F + M ++ + S S+A LEE EL+
Sbjct: 488 ELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLA---LEELELQK 544
Query: 675 HHILERLDAHIEELKRESE 693
IL + + +L++E+E
Sbjct: 545 KAILTESENKLRDLQQEAE 563
>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 94.0 bits (232), Expect = 4e-19
Identities = 150/762 (19%), Positives = 320/762 (41%), Gaps = 108/762 (14%)
Query: 22 EAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQ 81
E ++ L+K+ + + ++E EG A E C +L + QL+ KEV ++
Sbjct: 880 EEKMVTLLKEKNDLQLQVQAEAEGLADAEERC-----DQLIKTKIQLEAKIKEVT---ER 931
Query: 82 VEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQ------KKQMREFRGNTKNHRED 135
E+ E+I E+T + + KL +E LK+ + L+ +K+ KN E+
Sbjct: 932 AEDEEEINAELTAKKR----KLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEE 987
Query: 136 RSEIERLTAKI-------EEFRQKSLD-----------WEKQRLIYQQQVSSLEA---QR 174
+ ++ AK+ +E Q++LD K ++ +QQV LE Q
Sbjct: 988 MAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQE 1047
Query: 175 KALAEQSEIIQAQLV--------------NRKQKLESVELSSQSEIQHLSSKLERANDTI 220
K L E + +L N KQ+L+ + EI +L SK+E
Sbjct: 1048 KKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALG 1107
Query: 221 CANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQE 280
+ +I+ L R+ +L + + E++ + + LE + E E A +Q
Sbjct: 1108 IQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQI 1167
Query: 281 NLIHEARIQKEKLQEKVKATNTQHAVEAIRPRE---ESLAE---------------KKYT 322
+ + + +K++ ++ QH A R+ +S+AE +K
Sbjct: 1168 EMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEK 1227
Query: 323 SQGQGDLDSVLSQLNFTHTSEDLLQAEVTCLEGSLESVSATCKQLSQELMEKYEELKRME 382
S+ + ++D + S + ++ L+ LE L + + ++ + + + + R++
Sbjct: 1228 SEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQ 1287
Query: 383 AHNNEYKAEI---KKLKEQILQGEQSYSSALEGMKMEISHLTQELHQRDITIASTKGSSS 439
+ E+ ++ + L Q+ +G+Q+++ +E +K + L +E+ ++ + + S
Sbjct: 1288 TESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQ---LEEEIKAKNALAHALQSSRH 1344
Query: 440 DMEKRLRAEMQKAEDKAVEHKEILDQ--LESLKLENRHLSEMVMKLELGLHEAKEISLAD 497
D + LR + ++ ++ E + L + E + ++ ++ + + E L EAK+
Sbjct: 1345 DCD-LLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTE-ELEEAKKKLAQR 1402
Query: 498 LQ--ENYIEALN----KLVSENQQLQKDLMNTKSQLEISTQMC----KKQN--DRIFKPT 545
LQ E ++EA+N L Q+LQ ++ + +E + C KKQ D+I
Sbjct: 1403 LQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEW 1462
Query: 546 HSRTTEFKNTEFKPTHGQHRHDGIKTEHYKTDLHSPRGQASDSINPMSRVLSPLSPQISP 605
+ E + E + + + R G TE +K + + ++ D + + R L +IS
Sbjct: 1463 KQKCEE-THAELEASQKEARSLG--TELFK--IKNAYEESLDQLETLKRENKNLQQEISD 1517
Query: 606 CSSTRSLTSYSLCKTHSLPSALDTNEANFSDTMSE---SMNDQEEFISSCSLPVSPLGS- 661
+ + + + + ++ + + E S+ +E I L ++ + S
Sbjct: 1518 LTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSE 1577
Query: 662 ----IATRFLEEEELRSHH--ILERLDAHIEELKRESEKTVR 697
IA + E ++L+ +H I+E + + ++ R +R
Sbjct: 1578 VDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIR 1619
Score = 90.5 bits (223), Expect = 5e-18
Identities = 142/719 (19%), Positives = 293/719 (40%), Gaps = 103/719 (14%)
Query: 22 EAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQ 81
E + +L ++++ ++ + E G T A K RE E + +R L+ +
Sbjct: 1139 EKQRSDLSRELE-EISERLEEAGGATSAQIEMNKKREAEFQKMRRDLE----------EA 1187
Query: 82 VEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDRSEIER 141
+HE + ++ + +L E++ L+R +KL+K++ E + EI+
Sbjct: 1188 TLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKS-----------EMKMEIDD 1236
Query: 142 LTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNR-KQKLESVEL 200
L + +E + + EK + Q+S L+++ + EQ +I R + + ES E
Sbjct: 1237 LASNVETVSKAKGNLEKMCRTLEDQLSELKSKEE---EQQRLINDLTAQRGRLQTESGEF 1293
Query: 201 SSQ-SEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESE 259
S Q E + L S+L R + T ++ +L ++Q EE+++
Sbjct: 1294 SRQLDEKEALVSQLSRGK----------QAFTQQIEEL----------KRQLEEEIKAKN 1333
Query: 260 KLLEALQEEKRELKAAL-QSQENLIHEARIQK--EKLQEKVKATNTQHAVEAIRPREESL 316
L ALQ + + Q +E +A +Q+ K +V T++ +AI+ EE
Sbjct: 1334 ALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELE 1393
Query: 317 AEKKYTSQ----GQGDLDSVLSQLNFTHTSEDLLQAEVTCLEGSLESVSATCKQLSQE-- 370
KK +Q + +++V ++ ++ LQ EV L +E +A C L ++
Sbjct: 1394 EAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQR 1453
Query: 371 -----LMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSAL---EGMKMEISHLTQ 422
L E ++ + A + E + L ++ + + +Y +L E +K E +L Q
Sbjct: 1454 NFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQ 1513
Query: 423 ELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHK-EILDQLESLKLENRHLSEMVM 481
E+ D+T +G KR+ E++K + + + K E+ LE + H ++
Sbjct: 1514 EIS--DLTEQIAEGG-----KRIH-ELEKIKKQVEQEKCELQAALEEAEASLEHEEGKIL 1565
Query: 482 KLELGLHEAK----------EISLADLQENYI---EALNKLVSENQQLQKDLMNTKSQLE 528
+++L L++ K + + L+ N+I E++ + + + D + K ++E
Sbjct: 1566 RIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKME 1625
Query: 529 ISTQMCKKQNDRIFKPTHSRTTEFKNTE--FKPTHGQHRHDGIKTEHYKTDLHSPRGQAS 586
+ Q + + ++NT+ K T H D ++++ DL
Sbjct: 1626 GDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQ-IHLDDALRSQE---DLKEQLAMVE 1681
Query: 587 DSINPMSRVLSPLSPQISPCSSTRSLTSYSLCKTHSLPSALDTNEANFSDT-------MS 639
N + + L + +R + L L T + +T +S
Sbjct: 1682 RRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDIS 1741
Query: 640 ESMNDQEEFISSC-SLPVSPLGSIATRFLEEEELRSHHILERLDAHIEELKRESEKTVR 697
+ + E+ + + +I + EEL+ + AH+E +K+ E+TV+
Sbjct: 1742 QMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKE---QDTSAHLERMKKNMEQTVK 1797
Score = 86.3 bits (212), Expect = 9e-17
Identities = 114/552 (20%), Positives = 243/552 (44%), Gaps = 64/552 (11%)
Query: 22 EAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQ 81
+AELQ + + + VA ++++E T A++ ++ E + K L +L + V ++ +
Sbjct: 1360 KAELQRALSKANTEVAQWRTKYE--TDAIQRTEELEEAK-KKLAQRLQAAEEHVEAVNAK 1416
Query: 82 VEEHEKIKQEMTMEYKQ---ELKKLHEELCIL---KRSYEKLQ---KKQMREFRGNTKNH 132
EK KQ + E + ++++ + L +R+++K+ K++ E +
Sbjct: 1417 CASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEAS 1476
Query: 133 REDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVN-- 190
+++ + KI+ ++SLD Q+ +L+ + K L ++ + Q+
Sbjct: 1477 QKEARSLGTELFKIKNAYEESLD----------QLETLKRENKNLQQEISDLTEQIAEGG 1526
Query: 191 -RKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQ 249
R +LE ++ + E L + LE A ++ E +I R+ + +N + + E+
Sbjct: 1527 KRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKD 1586
Query: 250 QKEEKLRESE-KLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATN--TQHAV 306
++ ++L+ + +++E++Q L A ++S+ + I + + L E N + A
Sbjct: 1587 EEIDQLKRNHIRIVESMQST---LDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAA 1643
Query: 307 EAIRPREESLAEKKYTSQGQGDL----DSVLSQLNFTHTSEDLLQAEVTCLEGSLESVSA 362
EA+R + K T D + + QL +LLQAE+ L +LE
Sbjct: 1644 EALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTER 1703
Query: 363 TCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHLTQ 422
+ K QEL++ E ++ + N KKL+ I Q M+ E+ + Q
Sbjct: 1704 SRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQ-----------MQGEMEDILQ 1752
Query: 423 ELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMVMK 482
E A K + + + AE K E H LE +K +++ + V
Sbjct: 1753 EARN-----AEEKAKKAITDAAMMAEELKKEQDTSAH------LERMK---KNMEQTVKD 1798
Query: 483 LELGLHEAKEISLADLQENYIEALNKLVSENQQLQKDLMNTKSQLEISTQMCKKQNDRIF 542
L+L L EA++++L ++ + KL + ++L+ ++ + + + + + +K R+
Sbjct: 1799 LQLRLDEAEQLALKGGKKQ----IQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVK 1854
Query: 543 KPTHSRTTEFKN 554
+ T+ + KN
Sbjct: 1855 ELTYQTEEDRKN 1866
Score = 62.4 bits (150), Expect = 1e-09
Identities = 98/489 (20%), Positives = 197/489 (40%), Gaps = 60/489 (12%)
Query: 152 KSLDWEKQRLIYQQQVSSLEAQ-RKALAEQSEIIQAQLVNRKQKLESVELSSQSEIQHLS 210
KS + EK+ +++ ++ + K+ A++ E+ + + K+K ++L Q+E + L+
Sbjct: 847 KSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEK-NDLQLQVQAEAEGLA 905
Query: 211 SKLERANDTICAN---ELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQE 267
ER + I E +I+ +T R D E++ E + KL ++
Sbjct: 906 DAEERCDQLIKTKIQLEAKIKEVTERAED----------EEEINAELTAKKRKL----ED 951
Query: 268 EKRELKAALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAI-----RPREESLAEKKYT 322
E ELK + E + A+++KEK + K N + + + +E A ++
Sbjct: 952 ECSELKKDIDDLELTL--AKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAH 1009
Query: 323 SQGQGDLDSVLSQLNFTHTSEDLLQAEVTCLEGSLE-------SVSATCKQLSQELMEKY 375
Q DL + ++N ++ L+ +V LEGSLE + ++L +L
Sbjct: 1010 QQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQ 1069
Query: 376 EELKRMEAHNNEYKAEIKKLKEQI------LQGEQSYSSALE----GMKMEISHLTQELH 425
E + +E + ++KK + +I ++ EQ+ L+ ++ I L +E+
Sbjct: 1070 ESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIE 1129
Query: 426 QRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMVMKLEL 485
+ A + SD+ + L ++ E+ Q+E K +M LE
Sbjct: 1130 AERASRAKAEKQRSDLSRELEEISERLEEAGGATSA---QIEMNKKREAEFQKMRRDLEE 1186
Query: 486 GL--HEAKEISLADLQENYIEALNKLVSENQQLQKDLMNTKSQLEISTQMCKKQNDRIFK 543
HEA +L + + L + + Q++++ L KS++++ + + K
Sbjct: 1187 ATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSK 1246
Query: 544 PTHS-----RTTEFKNTEFKPTHGQHRHDGIKTEHYKTDLHSPRGQASDSINPMSRVLSP 598
+ RT E + +E K + + DL + RG+ SR L
Sbjct: 1247 AKGNLEKMCRTLEDQLSELKSKEEEQ-------QRLINDLTAQRGRLQTESGEFSRQLDE 1299
Query: 599 LSPQISPCS 607
+S S
Sbjct: 1300 KEALVSQLS 1308
Score = 53.9 bits (128), Expect = 5e-07
Identities = 87/363 (23%), Positives = 156/363 (42%), Gaps = 57/363 (15%)
Query: 3 ALLEGIQNRGHGGGFLTSCEAELQELMKQIDIMVAHKKSEWEG--RTHA--LETCLKIRE 58
AL E + H G + + EL ++ ++D +A K E + R H +E+ +
Sbjct: 1549 ALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLD 1608
Query: 59 QELKSLRSQLDVTHKEVGMLHQ---QVEEHEKIKQEMTMEYKQE---LKKLHEELCILKR 112
E++S + + K G L++ Q+ ++ E Y+ LK L R
Sbjct: 1609 AEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALR 1668
Query: 113 SYEKLQKK-QMREFRGNTKNHREDRSEIERLTAKIEEFR-------QKSLDW-EKQRLIY 163
S E L+++ M E R N ++EIE L A +E+ Q+ LD E+ +L++
Sbjct: 1669 SQEDLKEQLAMVERRANLL-----QAEIEELRATLEQTERSRKIAEQELLDASERVQLLH 1723
Query: 164 QQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESVELSSQSEI-------------QHLS 210
Q S + ++K + S++ Q ++ + Q+ + E ++ I Q S
Sbjct: 1724 TQNTSLINTKKKLETDISQM-QGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTS 1782
Query: 211 SKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQK-EEKLRESEKLLEALQEEK 269
+ LER + E ++ L +R+++ ++ ++Q QK E ++RE E +E+ Q+
Sbjct: 1783 AHLERMKKNM---EQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRN 1839
Query: 270 RELKAALQSQENLIHEARIQKE--------------KLQEKVKATNTQHAVEAIRPREES 315
E L+ E + E Q E KLQ KVK+ Q A EA +
Sbjct: 1840 AEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQ-AEEAEEQSNTN 1898
Query: 316 LAE 318
LA+
Sbjct: 1899 LAK 1901
Score = 42.0 bits (97), Expect = 0.002
Identities = 40/187 (21%), Positives = 90/187 (48%), Gaps = 3/187 (1%)
Query: 20 SCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHK-EVGML 78
+ E + ++ + +M K E + H LE K EQ +K L+ +LD + +
Sbjct: 1756 NAEEKAKKAITDAAMMAEELKKEQDTSAH-LERMKKNMEQTVKDLQLRLDEAEQLALKGG 1814
Query: 79 HQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDRSE 138
+Q+++ E +E+ E + E K+ E + L R +E+ K+ + + KN +
Sbjct: 1815 KKQIQKLEARVRELEGEVESEQKRNAEAVKGL-RKHERRVKELTYQTEEDRKNILRLQDL 1873
Query: 139 IERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESV 198
+++L AK++ +++++ + E+Q + L+ + + E+++I ++Q+ + K V
Sbjct: 1874 VDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQVNKLRVKSREV 1933
Query: 199 ELSSQSE 205
SE
Sbjct: 1934 HTKVISE 1940
>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 94.0 bits (232), Expect = 4e-19
Identities = 150/762 (19%), Positives = 320/762 (41%), Gaps = 108/762 (14%)
Query: 22 EAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQ 81
E ++ L+K+ + + ++E EG A E C +L + QL+ KEV ++
Sbjct: 880 EEKMVTLLKEKNDLQLQVQAEAEGLADAEERC-----DQLIKTKIQLEAKIKEVT---ER 931
Query: 82 VEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQ------KKQMREFRGNTKNHRED 135
E+ E+I E+T + + KL +E LK+ + L+ +K+ KN E+
Sbjct: 932 AEDEEEINAELTAKKR----KLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEE 987
Query: 136 RSEIERLTAKI-------EEFRQKSLD-----------WEKQRLIYQQQVSSLEA---QR 174
+ ++ AK+ +E Q++LD K ++ +QQV LE Q
Sbjct: 988 MAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQE 1047
Query: 175 KALAEQSEIIQAQLV--------------NRKQKLESVELSSQSEIQHLSSKLERANDTI 220
K L E + +L N KQ+L+ + EI +L SK+E
Sbjct: 1048 KKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALG 1107
Query: 221 CANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQE 280
+ +I+ L R+ +L + + E++ + + LE + E E A +Q
Sbjct: 1108 IQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQI 1167
Query: 281 NLIHEARIQKEKLQEKVKATNTQHAVEAIRPRE---ESLAE---------------KKYT 322
+ + + +K++ ++ QH A R+ +S+AE +K
Sbjct: 1168 EMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEK 1227
Query: 323 SQGQGDLDSVLSQLNFTHTSEDLLQAEVTCLEGSLESVSATCKQLSQELMEKYEELKRME 382
S+ + ++D + S + ++ L+ LE L + + ++ + + + + R++
Sbjct: 1228 SEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQ 1287
Query: 383 AHNNEYKAEI---KKLKEQILQGEQSYSSALEGMKMEISHLTQELHQRDITIASTKGSSS 439
+ E+ ++ + L Q+ +G+Q+++ +E +K + L +E+ ++ + + S
Sbjct: 1288 TESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQ---LEEEIKAKNALAHALQSSRH 1344
Query: 440 DMEKRLRAEMQKAEDKAVEHKEILDQ--LESLKLENRHLSEMVMKLELGLHEAKEISLAD 497
D + LR + ++ ++ E + L + E + ++ ++ + + E L EAK+
Sbjct: 1345 DCD-LLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTE-ELEEAKKKLAQR 1402
Query: 498 LQ--ENYIEALN----KLVSENQQLQKDLMNTKSQLEISTQMC----KKQN--DRIFKPT 545
LQ E ++EA+N L Q+LQ ++ + +E + C KKQ D+I
Sbjct: 1403 LQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEW 1462
Query: 546 HSRTTEFKNTEFKPTHGQHRHDGIKTEHYKTDLHSPRGQASDSINPMSRVLSPLSPQISP 605
+ E + E + + + R G TE +K + + ++ D + + R L +IS
Sbjct: 1463 KQKCEE-THAELEASQKEARSLG--TELFK--IKNAYEESLDQLETLKRENKNLQQEISD 1517
Query: 606 CSSTRSLTSYSLCKTHSLPSALDTNEANFSDTMSE---SMNDQEEFISSCSLPVSPLGS- 661
+ + + + + ++ + + E S+ +E I L ++ + S
Sbjct: 1518 LTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSE 1577
Query: 662 ----IATRFLEEEELRSHH--ILERLDAHIEELKRESEKTVR 697
IA + E ++L+ +H I+E + + ++ R +R
Sbjct: 1578 VDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIR 1619
Score = 90.5 bits (223), Expect = 5e-18
Identities = 142/719 (19%), Positives = 293/719 (40%), Gaps = 103/719 (14%)
Query: 22 EAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQ 81
E + +L ++++ ++ + E G T A K RE E + +R L+ +
Sbjct: 1139 EKQRSDLSRELE-EISERLEEAGGATSAQIEMNKKREAEFQKMRRDLE----------EA 1187
Query: 82 VEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDRSEIER 141
+HE + ++ + +L E++ L+R +KL+K++ E + EI+
Sbjct: 1188 TLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKS-----------EMKMEIDD 1236
Query: 142 LTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNR-KQKLESVEL 200
L + +E + + EK + Q+S L+++ + EQ +I R + + ES E
Sbjct: 1237 LASNVETVSKAKGNLEKMCRTLEDQLSELKSKEE---EQQRLINDLTAQRGRLQTESGEF 1293
Query: 201 SSQ-SEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESE 259
S Q E + L S+L R + T ++ +L ++Q EE+++
Sbjct: 1294 SRQLDEKEALVSQLSRGK----------QAFTQQIEEL----------KRQLEEEIKAKN 1333
Query: 260 KLLEALQEEKRELKAAL-QSQENLIHEARIQK--EKLQEKVKATNTQHAVEAIRPREESL 316
L ALQ + + Q +E +A +Q+ K +V T++ +AI+ EE
Sbjct: 1334 ALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELE 1393
Query: 317 AEKKYTSQ----GQGDLDSVLSQLNFTHTSEDLLQAEVTCLEGSLESVSATCKQLSQE-- 370
KK +Q + +++V ++ ++ LQ EV L +E +A C L ++
Sbjct: 1394 EAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQR 1453
Query: 371 -----LMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSAL---EGMKMEISHLTQ 422
L E ++ + A + E + L ++ + + +Y +L E +K E +L Q
Sbjct: 1454 NFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQ 1513
Query: 423 ELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHK-EILDQLESLKLENRHLSEMVM 481
E+ D+T +G KR+ E++K + + + K E+ LE + H ++
Sbjct: 1514 EIS--DLTEQIAEGG-----KRIH-ELEKIKKQVEQEKCELQAALEEAEASLEHEEGKIL 1565
Query: 482 KLELGLHEAK----------EISLADLQENYI---EALNKLVSENQQLQKDLMNTKSQLE 528
+++L L++ K + + L+ N+I E++ + + + D + K ++E
Sbjct: 1566 RIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKME 1625
Query: 529 ISTQMCKKQNDRIFKPTHSRTTEFKNTE--FKPTHGQHRHDGIKTEHYKTDLHSPRGQAS 586
+ Q + + ++NT+ K T H D ++++ DL
Sbjct: 1626 GDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQ-IHLDDALRSQE---DLKEQLAMVE 1681
Query: 587 DSINPMSRVLSPLSPQISPCSSTRSLTSYSLCKTHSLPSALDTNEANFSDT-------MS 639
N + + L + +R + L L T + +T +S
Sbjct: 1682 RRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDIS 1741
Query: 640 ESMNDQEEFISSC-SLPVSPLGSIATRFLEEEELRSHHILERLDAHIEELKRESEKTVR 697
+ + E+ + + +I + EEL+ + AH+E +K+ E+TV+
Sbjct: 1742 QMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKE---QDTSAHLERMKKNMEQTVK 1797
Score = 86.3 bits (212), Expect = 9e-17
Identities = 114/552 (20%), Positives = 243/552 (44%), Gaps = 64/552 (11%)
Query: 22 EAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQ 81
+AELQ + + + VA ++++E T A++ ++ E + K L +L + V ++ +
Sbjct: 1360 KAELQRALSKANTEVAQWRTKYE--TDAIQRTEELEEAK-KKLAQRLQAAEEHVEAVNAK 1416
Query: 82 VEEHEKIKQEMTMEYKQ---ELKKLHEELCIL---KRSYEKLQ---KKQMREFRGNTKNH 132
EK KQ + E + ++++ + L +R+++K+ K++ E +
Sbjct: 1417 CASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEAS 1476
Query: 133 REDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVN-- 190
+++ + KI+ ++SLD Q+ +L+ + K L ++ + Q+
Sbjct: 1477 QKEARSLGTELFKIKNAYEESLD----------QLETLKRENKNLQQEISDLTEQIAEGG 1526
Query: 191 -RKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQ 249
R +LE ++ + E L + LE A ++ E +I R+ + +N + + E+
Sbjct: 1527 KRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKD 1586
Query: 250 QKEEKLRESE-KLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATN--TQHAV 306
++ ++L+ + +++E++Q L A ++S+ + I + + L E N + A
Sbjct: 1587 EEIDQLKRNHIRIVESMQST---LDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAA 1643
Query: 307 EAIRPREESLAEKKYTSQGQGDL----DSVLSQLNFTHTSEDLLQAEVTCLEGSLESVSA 362
EA+R + K T D + + QL +LLQAE+ L +LE
Sbjct: 1644 EALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTER 1703
Query: 363 TCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHLTQ 422
+ K QEL++ E ++ + N KKL+ I Q M+ E+ + Q
Sbjct: 1704 SRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQ-----------MQGEMEDILQ 1752
Query: 423 ELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMVMK 482
E A K + + + AE K E H LE +K +++ + V
Sbjct: 1753 EARN-----AEEKAKKAITDAAMMAEELKKEQDTSAH------LERMK---KNMEQTVKD 1798
Query: 483 LELGLHEAKEISLADLQENYIEALNKLVSENQQLQKDLMNTKSQLEISTQMCKKQNDRIF 542
L+L L EA++++L ++ + KL + ++L+ ++ + + + + + +K R+
Sbjct: 1799 LQLRLDEAEQLALKGGKKQ----IQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVK 1854
Query: 543 KPTHSRTTEFKN 554
+ T+ + KN
Sbjct: 1855 ELTYQTEEDRKN 1866
Score = 62.4 bits (150), Expect = 1e-09
Identities = 98/489 (20%), Positives = 197/489 (40%), Gaps = 60/489 (12%)
Query: 152 KSLDWEKQRLIYQQQVSSLEAQ-RKALAEQSEIIQAQLVNRKQKLESVELSSQSEIQHLS 210
KS + EK+ +++ ++ + K+ A++ E+ + + K+K ++L Q+E + L+
Sbjct: 847 KSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEK-NDLQLQVQAEAEGLA 905
Query: 211 SKLERANDTICAN---ELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQE 267
ER + I E +I+ +T R D E++ E + KL ++
Sbjct: 906 DAEERCDQLIKTKIQLEAKIKEVTERAED----------EEEINAELTAKKRKL----ED 951
Query: 268 EKRELKAALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAI-----RPREESLAEKKYT 322
E ELK + E + A+++KEK + K N + + + +E A ++
Sbjct: 952 ECSELKKDIDDLELTL--AKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAH 1009
Query: 323 SQGQGDLDSVLSQLNFTHTSEDLLQAEVTCLEGSLE-------SVSATCKQLSQELMEKY 375
Q DL + ++N ++ L+ +V LEGSLE + ++L +L
Sbjct: 1010 QQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQ 1069
Query: 376 EELKRMEAHNNEYKAEIKKLKEQI------LQGEQSYSSALE----GMKMEISHLTQELH 425
E + +E + ++KK + +I ++ EQ+ L+ ++ I L +E+
Sbjct: 1070 ESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIE 1129
Query: 426 QRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMVMKLEL 485
+ A + SD+ + L ++ E+ Q+E K +M LE
Sbjct: 1130 AERASRAKAEKQRSDLSRELEEISERLEEAGGATSA---QIEMNKKREAEFQKMRRDLEE 1186
Query: 486 GL--HEAKEISLADLQENYIEALNKLVSENQQLQKDLMNTKSQLEISTQMCKKQNDRIFK 543
HEA +L + + L + + Q++++ L KS++++ + + K
Sbjct: 1187 ATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSK 1246
Query: 544 PTHS-----RTTEFKNTEFKPTHGQHRHDGIKTEHYKTDLHSPRGQASDSINPMSRVLSP 598
+ RT E + +E K + + DL + RG+ SR L
Sbjct: 1247 AKGNLEKMCRTLEDQLSELKSKEEEQ-------QRLINDLTAQRGRLQTESGEFSRQLDE 1299
Query: 599 LSPQISPCS 607
+S S
Sbjct: 1300 KEALVSQLS 1308
Score = 53.9 bits (128), Expect = 5e-07
Identities = 87/363 (23%), Positives = 156/363 (42%), Gaps = 57/363 (15%)
Query: 3 ALLEGIQNRGHGGGFLTSCEAELQELMKQIDIMVAHKKSEWEG--RTHA--LETCLKIRE 58
AL E + H G + + EL ++ ++D +A K E + R H +E+ +
Sbjct: 1549 ALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLD 1608
Query: 59 QELKSLRSQLDVTHKEVGMLHQ---QVEEHEKIKQEMTMEYKQE---LKKLHEELCILKR 112
E++S + + K G L++ Q+ ++ E Y+ LK L R
Sbjct: 1609 AEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALR 1668
Query: 113 SYEKLQKK-QMREFRGNTKNHREDRSEIERLTAKIEEFR-------QKSLDW-EKQRLIY 163
S E L+++ M E R N ++EIE L A +E+ Q+ LD E+ +L++
Sbjct: 1669 SQEDLKEQLAMVERRANLL-----QAEIEELRATLEQTERSRKIAEQELLDASERVQLLH 1723
Query: 164 QQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESVELSSQSEI-------------QHLS 210
Q S + ++K + S++ Q ++ + Q+ + E ++ I Q S
Sbjct: 1724 TQNTSLINTKKKLETDISQM-QGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTS 1782
Query: 211 SKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQK-EEKLRESEKLLEALQEEK 269
+ LER + E ++ L +R+++ ++ ++Q QK E ++RE E +E+ Q+
Sbjct: 1783 AHLERMKKNM---EQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRN 1839
Query: 270 RELKAALQSQENLIHEARIQKE--------------KLQEKVKATNTQHAVEAIRPREES 315
E L+ E + E Q E KLQ KVK+ Q A EA +
Sbjct: 1840 AEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQ-AEEAEEQSNTN 1898
Query: 316 LAE 318
LA+
Sbjct: 1899 LAK 1901
Score = 42.0 bits (97), Expect = 0.002
Identities = 40/187 (21%), Positives = 90/187 (48%), Gaps = 3/187 (1%)
Query: 20 SCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHK-EVGML 78
+ E + ++ + +M K E + H LE K EQ +K L+ +LD + +
Sbjct: 1756 NAEEKAKKAITDAAMMAEELKKEQDTSAH-LERMKKNMEQTVKDLQLRLDEAEQLALKGG 1814
Query: 79 HQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDRSE 138
+Q+++ E +E+ E + E K+ E + L R +E+ K+ + + KN +
Sbjct: 1815 KKQIQKLEARVRELEGEVESEQKRNAEAVKGL-RKHERRVKELTYQTEEDRKNILRLQDL 1873
Query: 139 IERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESV 198
+++L AK++ +++++ + E+Q + L+ + + E+++I ++Q+ + K V
Sbjct: 1874 VDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQVNKLRVKSREV 1933
Query: 199 ELSSQSE 205
SE
Sbjct: 1934 HTKVISE 1940
>gi|4506751 restin isoform a [Homo sapiens]
Length = 1427
Score = 92.8 bits (229), Expect = 1e-18
Identities = 159/795 (20%), Positives = 319/795 (40%), Gaps = 167/795 (21%)
Query: 42 EWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQE-- 99
E E + L T ++ ++E L +QL+ ++V L +VEE K ++ + K E
Sbjct: 405 ELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLETQTKLEHA 464
Query: 100 -LKKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDRSEIER-LTAKIEEFRQKSLDWE 157
+K+L + L K +KLQ +++ + R T + + E+E+ L +++E + E
Sbjct: 465 RIKELEQSLLFEKTKADKLQ-RELEDTRVATVSEKSRIMELEKDLALRVQEVAELRRRLE 523
Query: 158 KQRLIYQQQVS-SLEAQRKALAEQSEII----QAQLVNRKQKLESVELSSQSEI------ 206
+ +S SL + +L E+ E+ Q ++ + K+ + E + Q EI
Sbjct: 524 SNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTA 583
Query: 207 --------QHLSSKLERAN---------------DTICANELEIERLTMRVNDLVGTSMT 243
+ L SKLE AN I +++ +E L + + +GT
Sbjct: 584 TEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETA 643
Query: 244 VLQEQQQKEEKLR--------------ESE-------------KLLEALQEEKRELKA-- 274
E + + EK+R +SE KL++ ++E++ L+A
Sbjct: 644 EFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIR 703
Query: 275 ------------ALQSQENLIHEARIQKEKLQEKVKATNTQHAV-----EAIRPREESL- 316
++ N + EA I+ ++L+ N Q V ++ EE L
Sbjct: 704 SKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLL 763
Query: 317 ---AEKKYTSQGQGDLDSVLSQLNFTHTSEDLLQAEVTCLEGSLESVSATCKQLSQELME 373
A +K +S+G+ ++ + QL L+ E S++ + +L
Sbjct: 764 DLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTN 823
Query: 374 KYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHLTQELHQRDI---T 430
E L + + E++ LKE+ + + S M+ ++ L Q+ Q ++
Sbjct: 824 LQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSD 883
Query: 431 IASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILD---------------QL----ESLKL 471
+ + + +DME + R E + E++ ++ KE L+ QL + L+L
Sbjct: 884 LEKLRENLADMEAKFR-EKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRL 942
Query: 472 ENRHLSEMVMKLELGLHEAK--EISLADL----QENYIEALNKLVSENQQLQKDLMNTKS 525
+ R + E+ +KL A + S+ D+ +++ EA K E ++L++ L + +
Sbjct: 943 KERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEK 1002
Query: 526 QLEISTQMCKKQNDRIFKPTHSRTTEFK-----------NTEFKPTHGQHRHDGIKTEHY 574
++E S C++ R + T T+ + +TE K + + G+ E
Sbjct: 1003 KMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELE 1062
Query: 575 KTDLHSPRGQASDSINPMSRVLSPLSPQISPCSSTRSLTSYSLCKTHSLPSALDTNEANF 634
+ + + +A+ + +++ ++ + KT +L S DT + N
Sbjct: 1063 ELRKQADKAKAAQTAEDAMQIMEQMTKE----------------KTETLASLEDTKQTNA 1106
Query: 635 S-----DTMSE-SMNDQEEFISSCSLPVSPLGSIATRFLEEEELRSHHILERLDAHIEEL 688
DT+ E ++ + EE S L + + EE R IE L
Sbjct: 1107 KLQNELDTLKENNLKNVEELNKSKEL-------LTVENQKMEEFRK---------EIETL 1150
Query: 689 KRESEKTVRQFTALK 703
K+ + + +Q +AL+
Sbjct: 1151 KQAAAQKSQQLSALQ 1165
Score = 88.6 bits (218), Expect = 2e-17
Identities = 153/723 (21%), Positives = 304/723 (42%), Gaps = 130/723 (17%)
Query: 23 AELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQV 82
AE EL QI+ M + E E + ++ +E+++LR++L + ++ ++
Sbjct: 643 AEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKL------MKVIKEKE 696
Query: 83 EEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDRSEIERL 142
E I+ ++ Q L ++ + L L+ + K+++ ++ + + N E I+
Sbjct: 697 NSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCN-----EQTKVIDNF 751
Query: 143 TAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAE-QSEI--IQAQLVNRKQKLESVE 199
T++++ +K LD L+A RKA +E +SE+ ++ QL +++++ +E
Sbjct: 752 TSQLKATEEKLLD--------------LDALRKASSEGKSEMKKLRQQLEAAEKQIKHLE 797
Query: 200 LSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESE 259
+ +E SSK + EL++ L ++++ T+ +E Q +EK E+
Sbjct: 798 IEKNAE----SSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEAS 853
Query: 260 KLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKV---------KATNTQHAVEAIR 310
+ ++Q +E L +E + EKL+E + K + ++A
Sbjct: 854 EEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKE 913
Query: 311 PREESLAE-KKYTSQGQGDLDSVLSQLNFTHTSEDLLQAEVT-------CLEGSLESVSA 362
E +AE K + L + +L + LQ ++T L+ S+E ++
Sbjct: 914 KLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTV 973
Query: 363 TCKQLSQELMEKYEE------------LKRMEAHNNEYK----------AEIKKLKEQIL 400
+Q QE +K+EE K+ME +N+ + +E K E+IL
Sbjct: 974 KAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEIL 1033
Query: 401 QGEQ----SYSSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKA 456
Q Q L+G + E S L QEL E R +A+ KA A
Sbjct: 1034 QNLQKTLLDTEDKLKGAREENSGLLQELE----------------ELRKQADKAKAAQTA 1077
Query: 457 VEHKEILDQLESLKLEN----RHLSEMVMKLELGLHEAKEISLADLQENYIEALNK---- 508
+ +I++Q+ K E + KL+ L KE +L +++E LNK
Sbjct: 1078 EDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEE-----LNKSKEL 1132
Query: 509 LVSENQQLQKDLMNTKSQLEISTQMCKKQNDRIFKPTHSRTTEFKNTEFKPTHGQHRHDG 568
L ENQ++++ + ++E Q +++ ++ + +N + G+ R +
Sbjct: 1133 LTVENQKMEE----FRKEIETLKQAAAQKSQQL------SALQEENVKLAEELGRSRDE- 1181
Query: 569 IKTEHYKTDLHSPRGQASDSINPMSRVLSPLSPQISPCSSTRSLTSYSLCKTHSLPSALD 628
T H K L R ++ + M + S I ++ SL K+ S+ SAL
Sbjct: 1182 -VTSHQK--LEEERSVLNNQLLEMKKRESKF---IKDADEEKA----SLQKSISITSALL 1231
Query: 629 TNEANFSDTMSESMNDQEEFISSCSLPVSPLGSIATRFLEEEELRSHHILERLDAHIEEL 688
T + D E + ++ + + L S+ + LE ++++ ++ L+ ++E
Sbjct: 1232 TEK----DAELEKLRNEVTVLRGENASAKSLHSV-VQTLESDKVKLELKVKNLELQLKEN 1286
Query: 689 KRE 691
KR+
Sbjct: 1287 KRQ 1289
Score = 68.2 bits (165), Expect = 3e-11
Identities = 104/530 (19%), Positives = 224/530 (42%), Gaps = 58/530 (10%)
Query: 57 REQELKSLRSQLDVTHKEVGMLH-------QQVEEHEKIKQEMTMEYKQELKKLHEELCI 109
RE++L + +L+ E+ + ++ + ++K+ E + +L K +E
Sbjct: 904 REEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASF 963
Query: 110 LKRSYEKLQKKQMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLD-WEKQRLIYQQQVS 168
L++S E + K + + K H E++ E+ER + +E+ + S + ++ + Y++ S
Sbjct: 964 LQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATS 1023
Query: 169 SLEAQRKALAEQSEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELE-- 226
+ + + + + +Q L++ + KL+ + +Q L ++A+ A E
Sbjct: 1024 ETKTKHEEILQN---LQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDA 1080
Query: 227 ---IERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLI 283
+E++T + ++ L++ +Q KL+ L+ L+E + L + L+
Sbjct: 1081 MQIMEQMTKEKTE----TLASLEDTKQTNAKLQNE---LDTLKENNLKNVEELNKSKELL 1133
Query: 284 HEARIQKEKLQEKVKATNTQHAVEAIRPREESLAEKKYTSQGQGDLDSVLSQLNFTHTSE 343
++ +K++E K T A + ++ S +++ L L + TS
Sbjct: 1134 ---TVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVK-----LAEELGRSRDEVTSH 1185
Query: 344 DLLQAEVTCLEGSL----ESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQ- 398
L+ E + L L + S K +E + + A E AE++KL+ +
Sbjct: 1186 QKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNEV 1245
Query: 399 -ILQGEQSYSSALEGM--KMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDK 455
+L+GE + + +L + +E + EL +++ + + + Q ED+
Sbjct: 1246 TVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDE 1305
Query: 456 AVEHKEILDQLESLKLE-NRHLSEMVMKLELGLHEAKEISLADLQENYIEALNKLVSENQ 514
+ +I D L S+ ++ R ++ MK+E+ +S A L N + LN S++Q
Sbjct: 1306 RAQESQI-DFLNSVIVDLQRKNQDLKMKVEM-------MSEAALNGNG-DDLNNYDSDDQ 1356
Query: 515 QLQKDLMNTKSQLEISTQMCKKQNDRIFKPTHSRTTEFKNTEFKPTHGQH 564
+ Q K +L C +D PT ++ +E P H H
Sbjct: 1357 EKQS---KKKPRLFCDICDCFDLHDTEDCPTQAQMSE------DPPHSTH 1397
Score = 40.0 bits (92), Expect = 0.007
Identities = 41/216 (18%), Positives = 97/216 (44%), Gaps = 11/216 (5%)
Query: 25 LQELMKQIDIMVAH--KKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQV 82
++EL K +++ K E+ L+ + Q+L +L+ + +E+G +V
Sbjct: 1123 VEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEV 1182
Query: 83 EEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDRSEIERL 142
H+K+++E ++ Q L+ E +K + E+ Q + + E +E+E+L
Sbjct: 1183 TSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQ-KSISITSALLTEKDAELEKL 1241
Query: 143 TAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLES----V 198
++ R ++ + + V +LE+ + L + + ++ QL K++L S
Sbjct: 1242 RNEVTVLRGENASAKSLHSV----VQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNT 1297
Query: 199 ELSSQSEIQHLSSKLERANDTICANELEIERLTMRV 234
+ + + + S+++ N I + + + L M+V
Sbjct: 1298 DTQADEDERAQESQIDFLNSVIVDLQRKNQDLKMKV 1333
>gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens]
Length = 1417
Score = 92.8 bits (229), Expect = 1e-18
Identities = 143/727 (19%), Positives = 303/727 (41%), Gaps = 90/727 (12%)
Query: 18 LTSCEAELQELMKQIDIMVAHKKSEWE----------GRTHALETCLKIREQELKSLRSQ 67
L EAE +L + +AH+ S+++ + LE+ + + +L +L Q
Sbjct: 650 LIQIEAENSDLK----VNMAHRTSQFQLIQEELLEKASNSSKLESEMTKKCSQLLTLEKQ 705
Query: 68 LD---VTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMRE 124
L+ V + + + ++E+ K E + + HE++C+ ++EK +K + +
Sbjct: 706 LEEKIVAYSSIAAKNAELEQELMEKNEKIRSLETNINTEHEKICL---AFEKAKKIHLEQ 762
Query: 125 FRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQV----SSLEAQRKALAEQ 180
H+E +IERL A++E+ Q+ + EK + QQ + LE+ + L E
Sbjct: 763 -------HKEMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQDIICKQHHLESLDRLLTES 815
Query: 181 SEIIQAQLVNRKQKLESVELSSQSE---IQHLSSKLERANDTICANELEIERLTMRVNDL 237
++ + + + + L++++ E ++ L S LE IC E L + +N L
Sbjct: 816 KGEMKKENMKKDEALKALQNQVSEETIKVRQLDSALE-----ICK-----EELVLHLNQL 865
Query: 238 VGTSMTVLQEQQQKEEKLRESEKLLE----ALQEEKRE---LKAALQSQENLIHEARIQK 290
G ++ ++K E++ +K L+ +LQE + L+ LQ Q+ ++ + I+
Sbjct: 866 EGNKEKFEKQLKKKSEEVYCLQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRN 925
Query: 291 EKLQEKVKATNTQHAVEAIRPREESLAEKKYTSQGQGDLDSVLSQLNFTHTSEDLLQAEV 350
+L++ TQ +E + E +K+ S + L + + DL + +V
Sbjct: 926 GELED------TQTKLEKQVSKLEQELQKQRESSAE-KLRKMEEKCESAAHEADLKRQKV 978
Query: 351 TCLEGSLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQIL-----QGEQS 405
L G+ V Q +EL + +E+ ++ + E KA + IL + E+
Sbjct: 979 IELTGTARQVKIEMDQYKEELSKMEKEIMHLK-RDGENKAMHLSQLDMILDQTKTELEKK 1037
Query: 406 YSSALEGMKMEIS---HLTQELHQRDITIASTKGSSSDME------KRLRAEMQKA---- 452
++ E K++ S LT+ L +R++ + + +++ + LR +QKA
Sbjct: 1038 TNAVKELEKLQHSTETELTEALQKREVLETELQNAHGELKSTLRQLQELRDVLQKAQLSL 1097
Query: 453 EDKAVEHKEILDQLESLKLENRHLSEMVMKLELGLHEAK-EISLADLQENYIE-ALNKLV 510
E+K K++ +L K+E + +++++ L E E+ Q +++ + +
Sbjct: 1098 EEKYTTIKDLTAELRECKMEIEDKKQELLEMDQALKERNWELKQRAAQVTHLDMTIREHR 1157
Query: 511 SENQQLQKDLMNTKSQLEISTQMCKKQNDRIFKPTHSRTTEFKNTEFKPTHGQHRHDGIK 570
E +Q L T + E+ + C KQ + + + + + EF + +K
Sbjct: 1158 GEMEQKIIKLEGTLEKSELELKECNKQIESLNDKLQNAKEQLREKEFIMLQNEQEISQLK 1217
Query: 571 TEHYKTDLHSPRGQASDSINPMSRVLSPLSPQISPCSSTRSLTSYSLCKTHSLPSALDTN 630
E +T + + + ++ + LT + +H+ +
Sbjct: 1218 KEIERTQQRMK--EMESVMKEQEQYIATQYKEAIDLGQELRLTREQVQNSHT-----ELA 1270
Query: 631 EANFSDTMS----ESMNDQEEFISSCSLPVSPLGSIATRFLEEEELRSHHILERLDAHIE 686
EA + E ++ + E + S G+ L ++R H+ R+ A I+
Sbjct: 1271 EARHQQVQAQREIERLSSELEDMKQLSKEKDAHGNHLAEELGASKVREAHLEARMQAEIK 1330
Query: 687 ELKRESE 693
+L E E
Sbjct: 1331 KLSAEVE 1337
Score = 77.0 bits (188), Expect = 5e-14
Identities = 98/501 (19%), Positives = 216/501 (43%), Gaps = 56/501 (11%)
Query: 24 ELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQVE 83
EL++ +++ V+ + E + + + L+ E++ +S + D+ ++V L
Sbjct: 927 ELEDTQTKLEKQVSKLEQELQKQRESSAEKLRKMEEKCESAAHEADLKRQKVIELTGTAR 986
Query: 84 EHEKIKQEMTMEYKQELKKLHEELCILKRSYEK--LQKKQMREFRGNTKNHREDRSEIER 141
+ +K EM +YK+EL K+ +E+ LKR E + Q+ TK +E+E+
Sbjct: 987 Q---VKIEMD-QYKEELSKMEKEIMHLKRDGENKAMHLSQLDMILDQTK------TELEK 1036
Query: 142 LTAKIEEFR--QKSLDWEKQRLIYQQQVSSLEAQR---------KALAEQSEIIQAQLVN 190
T ++E Q S + E + +++V E Q + L E +++Q ++
Sbjct: 1037 KTNAVKELEKLQHSTETELTEALQKREVLETELQNAHGELKSTLRQLQELRDVLQKAQLS 1096
Query: 191 RKQKLESVE------LSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTV 244
++K +++ + EI+ +L + + E+++ +V L MT+
Sbjct: 1097 LEEKYTTIKDLTAELRECKMEIEDKKQELLEMDQALKERNWELKQRAAQVTHL---DMTI 1153
Query: 245 LQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQ-KEK----LQEKVKA 299
+ + + E+K+ + E LE + E +E ++S + + A+ Q +EK LQ + +
Sbjct: 1154 REHRGEMEQKIIKLEGTLEKSELELKECNKQIESLNDKLQNAKEQLREKEFIMLQNEQEI 1213
Query: 300 TNTQHAVEAIRPREESLA-----EKKYTSQGQGDLDSVLSQLNFTHTSEDLLQAEVTCLE 354
+ + +E + R + + +++Y + + + +L T E + + E
Sbjct: 1214 SQLKKEIERTQQRMKEMESVMKEQEQYIATQYKEAIDLGQELRLTR--EQVQNSHTELAE 1271
Query: 355 GSLESVSAT--CKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEG 412
+ V A ++LS EL + + K +AH N E+ K + E + ++
Sbjct: 1272 ARHQQVQAQREIERLSSELEDMKQLSKEKDAHGNHLAEELGASKVREAHLEARMQAEIKK 1331
Query: 413 MKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLE 472
+ E+ L + H I+ + + ++ A+ QK+ + ++ +QLE KLE
Sbjct: 1332 LSAEVESLKEAYHMEMIS-----HQENHAKWKISADSQKSSVQ-----QLNEQLEKAKLE 1381
Query: 473 NRHLSEMVMKLELGLHEAKEI 493
+ V L + + E+
Sbjct: 1382 LEEAQDTVSNLHQQVQDRNEV 1402
Score = 73.9 bits (180), Expect = 5e-13
Identities = 128/697 (18%), Positives = 294/697 (42%), Gaps = 79/697 (11%)
Query: 56 IREQELKSLRSQLDVTHKEVGMLHQQVEEHEKI---KQEMTMEYKQELKKLHEELCILKR 112
I E+++ +L +++ K + ++E+ +K+ K++ E K+E KL +L + +
Sbjct: 288 ILEEQIINLEAEVSAQDKVLREAENKLEQSQKMVIEKEQSLQESKEECIKLKVDL-LEQT 346
Query: 113 SYEKLQKKQMREFRGNTKN--------HREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQ 164
K ++Q E N + ++ ++E++ A+ E + + EK+ Q
Sbjct: 347 KQGKRAERQRNEALYNAEELSKAFQQYKKKVAEKLEKVQAEEEILERNLTNCEKENKRLQ 406
Query: 165 QQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANE 224
++ +++ + L E+ ++ + N K+KL + + + SE+ ++L + +I E
Sbjct: 407 ERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAVKN-SEVM---AQLTESRQSILKLE 462
Query: 225 LEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIH 284
E+E ++++ +++ E ++ + ++ + L+ Q+E + L+S E +I
Sbjct: 463 SELE----NKDEILRDKFSLMNENRELKVRVAAQNERLDLCQQEIESSRVELRSLEKIIS 518
Query: 285 EARIQKEKLQEKVKATNTQHAVEAIRPREESL-----AEKKYTSQGQGDL---DSVLSQL 336
+ +++E K+ +++ + + +E+ A K S+ + L ++ + +L
Sbjct: 519 QLPLKRELF--GFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISELRIKLAIKEAEIQKL 576
Query: 337 NFTHTSEDLLQAEVTCLEGSLESVSATCKQLSQEL--MEKYEELKRMEAH--NNEYKAE- 391
+ T+ L Q+ +TC + S ++ + +L + E +K H N +Y+ E
Sbjct: 577 HANLTANQLSQSLITCNDSQESSKLSSLETEPVKLGGHQVAESVKDQNQHTMNKQYEKER 636
Query: 392 ------IKKLKEQILQGEQSYSSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRL 445
I++L+ +++Q E S +K+ ++H T + + +SS +E +
Sbjct: 637 QRLVTGIEELRTKLIQIEAENSD----LKVNMAHRTSQFQLIQEELLEKASNSSKLESEM 692
Query: 446 RAEM-------QKAEDKAVEHKEILDQLESLKLENRHLSEMVMKLE-----------LGL 487
+ ++ E+K V + I + L+ E +E + LE L
Sbjct: 693 TKKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQELMEKNEKIRSLETNINTEHEKICLAF 752
Query: 488 HEAKEISLADLQ--ENYIEALNKLVSENQQLQKDLMNTKSQLEISTQMCKKQN----DRI 541
+AK+I L + E IE L + + Q K+ T S L+ +CK+ + DR+
Sbjct: 753 EKAKKIHLEQHKEMEKQIERLEAQLEKKDQQFKEQEKTMSMLQ-QDIICKQHHLESLDRL 811
Query: 542 F---KPTHSRTTEFKNTEFKPTHGQHRHDGIKTEHYKTDLHSPRGQASDSINPMSRVLSP 598
K + K+ K Q + IK + L + + +N +
Sbjct: 812 LTESKGEMKKENMKKDEALKALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEK 871
Query: 599 LSPQISPCS-STRSLTSYSLCKTHSLPSALDTNEANFSDTMSESMNDQEEFISSCSLPVS 657
Q+ S L K HSL +T+E N + ++ Q++ + ++
Sbjct: 872 FEKQLKKKSEEVYCLQKELKIKNHSLQ---ETSEQNV--ILQHTLQQQQQMLQQETIRNG 926
Query: 658 PLGSIATRFLEEEELRSHHILERLDAHIEELKRESEK 694
L T+ ++ + ++ ++ E+L++ EK
Sbjct: 927 ELEDTQTKLEKQVSKLEQELQKQRESSAEKLRKMEEK 963
Score = 46.2 bits (108), Expect = 1e-04
Identities = 114/553 (20%), Positives = 225/553 (40%), Gaps = 80/553 (14%)
Query: 180 QSEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRV----- 234
+ E + A + + + +L+ E S QS + LSS N N E+L + V
Sbjct: 132 EEESLLANVASLRHELKITEWSLQSLGEELSSVSPSENSDYAPNPSRSEKLILDVQPSHP 191
Query: 235 --------NDLVGTSMTVLQEQQQKEEKLRES----EKLLEALQEEKRELK---AALQSQ 279
++ S + Q++ +K+ S ++ +++L+E+ +L+ A L +Q
Sbjct: 192 GLLNYSPYENVCKISGSSTDFQKKPRDKMFSSSAPVDQEIKSLREKLNKLRQQNACLVTQ 251
Query: 280 EN--LIHEARIQKEKLQEKVKAT---NTQHAVEAIRPREESLAEKKYTSQGQGDLDSVLS 334
+ + I E Q + K + + Q ++ EE + + Q D VL
Sbjct: 252 NHSLMTKFESIHFELTQSRAKVSMLESAQQQAASVPILEEQIINLEAEVSAQ---DKVLR 308
Query: 335 QLNFTHTSEDLLQAEVTCLEGSLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKK 394
+ + Q V E SL+ C +L +L+E+ ++ KR E NE ++
Sbjct: 309 E---AENKLEQSQKMVIEKEQSLQESKEECIKLKVDLLEQTKQGKRAERQRNEALYNAEE 365
Query: 395 LKEQILQGEQSYSSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRL--RAEMQKA 452
L + Q ++ + LE ++ E +E+ +R++T + KRL R + K+
Sbjct: 366 LSKAFQQYKKKVAEKLEKVQAE-----EEILERNLT------NCEKENKRLQERCGLYKS 414
Query: 453 EDKAVEHKEILDQLESLKLENRHLSEMVMKLELGLHEAKEI--SLADLQENYIEALNKLV 510
E + ++ K L LK EN + E KL + + E+ L + +++ ++ ++L
Sbjct: 415 ELEILKEK-----LRQLKEENNNGKE---KLRIMAVKNSEVMAQLTESRQSILKLESELE 466
Query: 511 SENQQLQK--DLMNTKSQLEISTQMCKKQNDRIFKPTHSRTTEFKNTEFKPTHGQHRHDG 568
++++ L+ LMN +L++ QN+R+ + E E +
Sbjct: 467 NKDEILRDKFSLMNENRELKVRV---AAQNERL--DLCQQEIESSRVELRSLEKIISQLP 521
Query: 569 IKTEHYKTDLHSPRGQASDSINPMSRVLSPLSPQISPCSSTRSLTSYSLCKTHSLPSALD 628
+K E + + + Q S N R I C + + + S K + +
Sbjct: 522 LKRELFGFKSYLSKYQMSSFSNKEDRC-------IGCCEANKLVISELRIKLAIKEAEIQ 574
Query: 629 TNEANF-SDTMSESM---NDQEEFISSCSLPVSPLGSIATRFLEEEELRSHHIL------ 678
AN ++ +S+S+ ND +E SL P+ + E + ++ H +
Sbjct: 575 KLHANLTANQLSQSLITCNDSQESSKLSSLETEPVKLGGHQVAESVKDQNQHTMNKQYEK 634
Query: 679 --ERLDAHIEELK 689
+RL IEEL+
Sbjct: 635 ERQRLVTGIEELR 647
>gi|31982906 cingulin-like 1 [Homo sapiens]
Length = 1302
Score = 91.7 bits (226), Expect = 2e-18
Identities = 108/501 (21%), Positives = 217/501 (43%), Gaps = 48/501 (9%)
Query: 58 EQELKSLRSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKL 117
+Q +K R ++ +E+ H + E Q+ E + EL+K EEL +K E+
Sbjct: 637 QQNIKEERERMRANLEELRSQHNEKVEENSTLQQRLEESEGELRKNLEELFQVKMEREQH 696
Query: 118 QKKQMREFRGNTKNHRED-----RSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEA 172
Q ++R+ + ++ RSE A IEE Q D + + ++Q L
Sbjct: 697 QT-EIRDLQDQLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRK 755
Query: 173 QRKALAEQSEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTM 232
+ + L ++ ++ + Q+++ ++ +E+Q L +E A + E+ R
Sbjct: 756 RERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNV---EVLASRSNT 812
Query: 233 RVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEK 292
D GT M V + LQEE +L+ + E + + + Q E
Sbjct: 813 SEQDQAGTEMRV------------------KLLQEENEKLQGRSEELERRVAQLQRQIED 854
Query: 293 LQ-EKVKATNTQHAVEA-IRPREESLAEKKYTSQGQGDLDSVLSQLNFTHTSEDLLQAEV 350
L+ ++ KA T E IR EE+L + + + ++V ++ L+ E+
Sbjct: 855 LKGDEAKAKETLKKYEGEIRQLEEALVHAR-----KEEKEAV--------SARRALENEL 901
Query: 351 TCLEGSLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSAL 410
+G+L + KQLS++L E+ E+ +++ NE + E L + I + ++ + +
Sbjct: 902 EAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIV 961
Query: 411 EGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLK 470
E + L +L D + ++M+++L+ + +AE + ++ D++ ++
Sbjct: 962 EASRTSTLELQNQL---DEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLME 1018
Query: 471 LENRHLSEMVMKLELGLHEAKEISLADLQENYIEALNKLVSENQQLQKDLMNTKSQLEIS 530
E R + L + E +L DL E +EA + L + +L K + + SQLE+
Sbjct: 1019 EELRDY-QRAQDEALTKRQLLEQTLKDL-EYELEAKSHLKDDRSRLVKQMEDKVSQLEME 1076
Query: 531 TQMCKKQNDRIFKPTHSRTTE 551
+ ++ N + SR+ E
Sbjct: 1077 LEE-ERNNSDLLSERISRSRE 1096
Score = 84.3 bits (207), Expect = 3e-16
Identities = 111/452 (24%), Positives = 192/452 (42%), Gaps = 54/452 (11%)
Query: 99 ELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEK 158
E+K L E+ L +LQ++ E + N +N +E+R ER+ A +EE R + + +
Sbjct: 608 EVKDLLEQKSKLTIEVAELQRQLQLEVK-NQQNIKEER---ERMRANLEELRSQHNEKVE 663
Query: 159 QRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESVELSSQ-SEIQHLSSKLERAN 217
+ QQ++ E + + E E+ Q ++ + + E +L Q SE+ +R+
Sbjct: 664 ENSTLQQRLEESEGELRKNLE--ELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSE 721
Query: 218 DTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQ 277
D IE L DL +L ++++E+ LR+ E+ L A LK AL+
Sbjct: 722 DR--EKGALIEELLQAKQDL----QDLLIAKEEQEDLLRKRERELTA-------LKGALK 768
Query: 278 SQENLIHEARIQKEKLQEKVKATNTQHAVEAIRPREESLAEKKYTSQGQGDLDSVLSQLN 337
+E H+ + K K Q + + +VE E LA + TS+
Sbjct: 769 -EEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSE---------QDQA 818
Query: 338 FTHTSEDLLQAEVTCLEGSLESVSATCKQLSQELMEKYEELKRMEAHNNE----YKAEIK 393
T LLQ E L+G E + QL +++ E+LK EA E Y+ EI+
Sbjct: 819 GTEMRVKLLQEENEKLQGRSEELERRVAQLQRQI----EDLKGDEAKAKETLKKYEGEIR 874
Query: 394 KLKEQILQGEQSYSSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAE 453
+L+E ++ + A+ + L EL ++ T + ++L+ E
Sbjct: 875 QLEEALVHARKEEKEAVSARRA----LENELEAAQGNLSQTTQEQKQLSEKLKEES---- 926
Query: 454 DKAVEHKEILDQLES-LKLENRHLSEMVMKLE---LGLHEAKEISLADLQENYIEALNKL 509
E KE L +L++ ++ E HL + + KL+ + EA S +LQ E K
Sbjct: 927 ----EQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKN 982
Query: 510 VSENQQLQKDLMNTKSQLEISTQMCKKQNDRI 541
E ++Q+ L + E S K D +
Sbjct: 983 RRELAEMQRQLKEKTLEAEKSRLTAMKMQDEM 1014
Score = 80.1 bits (196), Expect = 6e-15
Identities = 134/617 (21%), Positives = 254/617 (41%), Gaps = 114/617 (18%)
Query: 18 LTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGM 77
L E EL++ ++++ V ++ + + L+ L EL S + D +E G
Sbjct: 672 LEESEGELRKNLEEL-FQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSED---REKGA 727
Query: 78 LHQQV--------------EEHEKI----KQEMT----------MEYKQELKKLHE---- 105
L +++ EE E + ++E+T + QE+ KL E
Sbjct: 728 LIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDA 787
Query: 106 ELCILKRSYEKLQKK-QMREFRGNTKNHREDRSE--IERLTAKIEEFRQKSLDWEKQRLI 162
EL L+ S E+ K ++ R NT + +E ++ L + E+ + +S + E++
Sbjct: 788 ELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQ 847
Query: 163 YQQQVSSL--------EAQRKALAEQSEIIQAQLVNRKQKLESVEL-------------- 200
Q+Q+ L E +K E ++ +A + RK++ E+V
Sbjct: 848 LQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGN 907
Query: 201 --SSQSEIQHLSSKLERAND-----TICANELE---------IERLTMRVNDLVGTSMTV 244
+ E + LS KL+ ++ NE+E IE+L + D+V S T
Sbjct: 908 LSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTS 967
Query: 245 LQEQQQ-----KEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKA 299
E Q KE+ RE ++ L+E+ E + + + + E R+ +E+L++ +A
Sbjct: 968 TLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRA 1027
Query: 300 -----TNTQHAVEAIRPREESLAEKKYTSQGQG----DLDSVLSQLNF----THTSEDLL 346
T Q + ++ E L K + + ++ +SQL + DLL
Sbjct: 1028 QDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEERNNSDLL 1087
Query: 347 QAEVTCLEGSLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSY 406
++ +E QL EL+++ + +E + + K LK +I+ E SY
Sbjct: 1088 SERISRSREQME-------QLRNELLQERAARQDLECDKISLERQNKDLKSRIIHLEGSY 1140
Query: 407 SSALEG----MKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEI 462
S+ EG M+ I+ L L + A+ + S+ +E++++ + + +D EH +
Sbjct: 1141 RSSKEGLVVQMEARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDD---EHLSL 1197
Query: 463 LDQLESLKLENRHLSEMVMKLELGLHEAKEISLADLQENYIEALNKLVSENQQLQKDLMN 522
DQ + L L + + V + E + + E S LQ L + + N+ LQ L +
Sbjct: 1198 TDQKDQLSLRLKAMKRQVEEAEEEI-DRLESSKKKLQRE----LEEQMDMNEHLQGQLNS 1252
Query: 523 TKSQLEISTQMCKKQND 539
K L + K +D
Sbjct: 1253 MKKDLRLKKLPSKVLDD 1269
Score = 68.6 bits (166), Expect = 2e-11
Identities = 86/401 (21%), Positives = 181/401 (45%), Gaps = 49/401 (12%)
Query: 150 RQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKL--ESVELSSQSEIQ 207
R+ +L +EK + + + S + +A SE+ L+ +K KL E EL Q +++
Sbjct: 576 RKVNLVFEKIQTLKSRAAGSAQGNNQACNSTSEV--KDLLEQKSKLTIEVAELQRQLQLE 633
Query: 208 HLSSK-LERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQ 266
+ + ++ + + AN +E L + N+ V + T+ Q ++ E +LR++ + L ++
Sbjct: 634 VKNQQNIKEERERMRAN---LEELRSQHNEKVEENSTLQQRLEESEGELRKNLEELFQVK 690
Query: 267 EEKRELKAA---LQSQENLIHEARIQKEKLQEKVKATNTQHAVEAIRPREESLAEKKYTS 323
E+ + + LQ Q + +H+ ++ +++ K + ++A + ++ L K+
Sbjct: 691 MEREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQDLLIAKE--- 747
Query: 324 QGQGDLDSVLSQLNFTHTSEDLL---QAEVTCLEGSLESVSATCKQLSQELMEKYE-ELK 379
EDLL + E+T L+G+L+ ++ Q +L E+Y+ EL+
Sbjct: 748 -----------------EQEDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQ 790
Query: 380 RMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHLTQELHQRDITIASTKGSSS 439
+ E ++ L + EQ + G +M + L +E + +G S
Sbjct: 791 ALRESVEEATKNVEVLASRSNTSEQDQA----GTEMRVKLLQEENEK-------LQGRSE 839
Query: 440 DMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMVMKLELGLHEAKEISLADLQ 499
++E+R+ ++ ED + + + L+ + E R L E ++ E + +S
Sbjct: 840 ELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHAR--KEEKEAVSARRAL 897
Query: 500 ENYIEALNKLVSENQQLQKDLM-NTKSQLEISTQMCKKQND 539
EN +EA +S+ Q QK L K + E Q+ + +N+
Sbjct: 898 ENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNE 938
>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
sapiens]
Length = 1937
Score = 90.9 bits (224), Expect = 4e-18
Identities = 159/759 (20%), Positives = 311/759 (40%), Gaps = 122/759 (16%)
Query: 22 EAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQ 81
E ++ L+K+ + + +SE + A E C EQ +K+ + QL+ KEV ++
Sbjct: 877 EEKMVTLLKEKNDLQLQVQSEADSLADAEERC----EQLIKN-KIQLEAKIKEVT---ER 928
Query: 82 VEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQ------KKQMREFRGNTKNHRED 135
EE E+I E+T + + KL +E LK+ + L+ +K+ KN E+
Sbjct: 929 AEEEEEINAELTAKKR----KLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEE 984
Query: 136 RSEIERLTAKI-------EEFRQKSLD-----------WEKQRLIYQQQVSSLE------ 171
+ ++ AK+ +E Q++LD K + +QQV LE
Sbjct: 985 MAGLDETIAKLSKEKKALQETHQQTLDDLQAEEDKVNILTKAKTKLEQQVDDLEGSLEQE 1044
Query: 172 ---------AQRKA-----LAEQSEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERAN 217
A+RK LA++S + + N KQ+L+ + EI +L SK+E
Sbjct: 1045 KKLRMDLERAKRKLEGDLKLAQESTM---DMENDKQQLDEKLEKKEFEISNLISKIEDEQ 1101
Query: 218 DTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLR-ESEKLLEALQEEKRELKAAL 276
+ +I+ L R+ +L G + + + K EK R + + LE + E E A
Sbjct: 1102 AVEIQLQKKIKELQARIEEL-GEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGAT 1160
Query: 277 QSQENLIHEARIQKEKLQEKVKATNTQH--AVEAIRPRE-ESLAEK----KYTSQGQGDL 329
+Q L + + +KL+ ++ QH V A+R + +S+AE + + L
Sbjct: 1161 SAQVELNKKREAEFQKLRRDLEEATLQHEAMVAALRKKHADSMAELGEQIDNLQRVKQKL 1220
Query: 330 DSVLSQLNFTHTSEDLLQAEVTCLEGSLESVSATCKQLSQELMEKYEELK---------- 379
+ S+L ++ +G+LE + + + EL K EE +
Sbjct: 1221 EKEKSELKMETDDLSSNAEAISKAKGNLEKMCRSLEDQVSELKTKEEEQQRLINDLTAQR 1280
Query: 380 -RMEAHNNEYKAEIKK---LKEQILQGEQSYSSALEGMKMEISHLTQELHQRDITIASTK 435
R++ EY ++ + L Q+ + +Q+ + +E +K ++ T+ + + S++
Sbjct: 1281 ARLQTEAGEYSRQLDEKDALVSQLSRSKQASTQQIEELKHQLEEETKAKNALAHALQSSR 1340
Query: 436 GSSS------DMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMVMKLELGLHE 489
+ E+ +AE+Q+A KA E + ++ ++ + + E L E
Sbjct: 1341 HDCDLLREQYEEEQEGKAELQRALSKA--------NSEVAQWRTKYETDAIQRTE-ELEE 1391
Query: 490 AKEISLADLQ--ENYIEALN----KLVSENQQLQKDLMNTKSQLEISTQMC---KKQNDR 540
AK+ LQ E ++EA+N L Q+LQ ++ + +E S C K+
Sbjct: 1392 AKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSNAACAALDKKQRN 1451
Query: 541 IFKPTHSRTTEFKNTEFKPTHGQHRHDGIKTEHYKTDLHSPRGQASDSINPMSRVLSPLS 600
K +++ T+ + Q + TE +K + + ++ D + + R L
Sbjct: 1452 FDKVLSEWKQKYEETQAELEASQKESRSLSTELFK--VKNVYEESLDQLETLRRENKNLQ 1509
Query: 601 PQISPCSSTRSLTSYSLCKTHSLPSALDTNEANFSDTMSE---SMNDQEEFISSCSLPVS 657
+IS + + + + + ++ + + E S+ +E I L ++
Sbjct: 1510 QEISDLTEQIAEGGKQIHELEKIKKQVEQEKCEIQAALEEAEASLEHEEGKILRIQLELN 1569
Query: 658 PLGSIATRFLEEEELRSHHILERLDAHIEELKRESEKTV 696
+ S R + E+ D I++LKR + V
Sbjct: 1570 QVKSEVDRKIAEK-----------DEEIDQLKRNHTRVV 1597
Score = 87.0 bits (214), Expect = 5e-17
Identities = 160/765 (20%), Positives = 309/765 (40%), Gaps = 106/765 (13%)
Query: 27 ELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQVEEHE 86
E K++ + + K + EG + E + + L +L+ E+ L ++E+ +
Sbjct: 1042 EQEKKLRMDLERAKRKLEGDLKLAQESTMDMENDKQQLDEKLEKKEFEISNLISKIEDEQ 1101
Query: 87 KIK---QEMTMEYKQELKKLHEELCILKRSYEKLQKKQM---REFRGNTKNHRE----DR 136
++ Q+ E + +++L EE+ + S K +K++ RE ++ E
Sbjct: 1102 AVEIQLQKKIKELQARIEELGEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATS 1161
Query: 137 SEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRK-ALAEQSEIIQAQLVNRKQKL 195
+++E + EF++ D E+ L ++ V++L + ++AE E I L KQKL
Sbjct: 1162 AQVELNKKREAEFQKLRRDLEEATLQHEAMVAALRKKHADSMAELGEQID-NLQRVKQKL 1220
Query: 196 ESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKL 255
E + + E LSS E I + +E++ + D V T +EQQ+ L
Sbjct: 1221 EKEKSELKMETDDLSSNAE----AISKAKGNLEKMCRSLEDQVSELKTKEEEQQRLINDL 1276
Query: 256 RESEKLLEA-LQEEKREL--KAALQSQENLIHEARIQ-----KEKLQEKVKATNT-QHAV 306
L+ E R+L K AL SQ + +A Q K +L+E+ KA N HA+
Sbjct: 1277 TAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQASTQQIEELKHQLEEETKAKNALAHAL 1336
Query: 307 EAIRPREESLAEKKYTSQ-GQGDLDSVLSQLNFTHTSEDLLQAEVTCLEGSLESVSATCK 365
++ R + L E+ Q G+ +L LS+ N + ++ + E ++ + E + K
Sbjct: 1337 QSSRHDCDLLREQYEEEQEGKAELQRALSKAN-SEVAQWRTKYETDAIQRT-EELEEAKK 1394
Query: 366 QLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHLTQELH 425
+L+Q L E E ++ + A A ++K K+++ + +E + L ++
Sbjct: 1395 KLAQRLQEAEEHVEAVNAKC----ASLEKTKQRLQNEVEDLMLDVERSNAACAALDKKQR 1450
Query: 426 QRDITIASTKGSSSDMEKRLRAEMQKAEDKAVE-------HKEILDQLESLKLENRHLSE 478
D ++ K + + L A +++ + E ++E LDQLE+L+ EN++L +
Sbjct: 1451 NFDKVLSEWKQKYEETQAELEASQKESRSLSTELFKVKNVYEESLDQLETLRRENKNLQQ 1510
Query: 479 MVMKL-----ELG--LHEAKEISL------ADLQENYIEALNKLVSENQQL---QKDLMN 522
+ L E G +HE ++I ++Q EA L E ++ Q +L
Sbjct: 1511 EISDLTEQIAEGGKQIHELEKIKKQVEQEKCEIQAALEEAEASLEHEEGKILRIQLELNQ 1570
Query: 523 TKSQLEISTQMCKKQNDRIFKPTHSRTTEFKNTEF--------------KPTHGQHRHDG 568
KS+++ ++ D++ K H+R E + K G
Sbjct: 1571 VKSEVDRKIAEKDEEIDQL-KRNHTRVVETMQSTLDAEIRSRNDALRVKKKMEGDLNEME 1629
Query: 569 IKTEHY-------------------KTDLH---SPRGQ---------ASDSINPMSRVLS 597
I+ H +T LH + RGQ N + +
Sbjct: 1630 IQLNHANRLAAESLRNYRNTQGILKETQLHLDDALRGQEDLKEQLAIVERRANLLQAEIE 1689
Query: 598 PLSPQISPCSSTRSLTSYSLCKTHSLPSALDTNEANFSDTMSESMNDQEEFISSCSLPVS 657
L + +R + L L T + +T + ND + S +
Sbjct: 1690 ELWATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLENDVSQLQSEVEEVIQ 1749
Query: 658 PLGSI---ATRFLEEEELRSHHILERLD--AHIEELKRESEKTVR 697
+ A + + + + + + + D AH+E +K+ E+TV+
Sbjct: 1750 ESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVK 1794
Score = 85.5 bits (210), Expect = 2e-16
Identities = 114/551 (20%), Positives = 242/551 (43%), Gaps = 62/551 (11%)
Query: 22 EAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQ 81
+AELQ + + + VA ++++E T A++ ++ E + K L +L + V ++ +
Sbjct: 1357 KAELQRALSKANSEVAQWRTKYE--TDAIQRTEELEEAK-KKLAQRLQEAEEHVEAVNAK 1413
Query: 82 VEEHEKIKQEMTMEYKQELKKLHEE--LCILKRSYEKLQKKQMREFRGNTKNHREDRSEI 139
EK KQ + E + + + C ++ K + E++ + + E ++E+
Sbjct: 1414 CASLEKTKQRLQNEVEDLMLDVERSNAACAALDKKQRNFDKVLSEWK---QKYEETQAEL 1470
Query: 140 ERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKA----LAEQSEIIQAQLVNRKQ-- 193
E A +E R S + K + +Y++ + LE R+ E S++ + KQ
Sbjct: 1471 E---ASQKESRSLSTELFKVKNVYEESLDQLETLRRENKNLQQEISDLTEQIAEGGKQIH 1527
Query: 194 KLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEE 253
+LE ++ + E + + LE A ++ E +I R+ + +N + + E+ ++ +
Sbjct: 1528 ELEKIKKQVEQEKCEIQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEID 1587
Query: 254 KLRESE-KLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATNTQH--AVEAIR 310
+L+ + +++E +Q L A ++S+ + + + + L E N + A E++R
Sbjct: 1588 QLKRNHTRVVETMQST---LDAEIRSRNDALRVKKKMEGDLNEMEIQLNHANRLAAESLR 1644
Query: 311 PREESLAEKKYTS-------QGQGDLDSVLSQLNFTHTSEDLLQAEVTCLEGSLESVSAT 363
+ K T +GQ DL QL +LLQAE+ L +LE +
Sbjct: 1645 NYRNTQGILKETQLHLDDALRGQEDLKE---QLAIVERRANLLQAEIEELWATLEQTERS 1701
Query: 364 CKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHLTQE 423
K QEL++ E ++ + N KKL+ + Q ++ E+ + QE
Sbjct: 1702 RKIAEQELLDASERVQLLHTQNTSLINTKKKLENDVSQ-----------LQSEVEEVIQE 1750
Query: 424 LHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMVMKL 483
S + E++ + + A A E K+ D L+ ++L + V L
Sbjct: 1751 --------------SRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDL 1796
Query: 484 ELGLHEAKEISLADLQENYIEALNKLVSENQQLQKDLMNTKSQLEISTQMCKKQNDRIFK 543
+ L EA++++L ++ + KL + ++L+ ++ N + + + + +K R+ +
Sbjct: 1797 QHRLDEAEQLALKGGKKQ----IQKLEARVRELEGEVENEQKRNAEAVKGLRKHERRVKE 1852
Query: 544 PTHSRTTEFKN 554
T+ + KN
Sbjct: 1853 LTYQTEEDRKN 1863
Score = 68.2 bits (165), Expect = 3e-11
Identities = 104/506 (20%), Positives = 214/506 (42%), Gaps = 61/506 (12%)
Query: 137 SEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLE 196
+E E+ A ++E QK+ D +++ EA+RK L E+ +V ++
Sbjct: 846 AETEKEMATMKEEFQKTKD----------ELAKSEAKRKELEEK-------MVTLLKEKN 888
Query: 197 SVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLR 256
++L QSE L+ ER I N++++E V + + E K+ KL
Sbjct: 889 DLQLQVQSEADSLADAEERCEQLI-KNKIQLEAKIKEVTERAEEEEEINAELTAKKRKL- 946
Query: 257 ESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAIRPREESL 316
++E ELK + E + A+++KEK + K N + + L
Sbjct: 947 ---------EDECSELKKDIDDLELTL--AKVEKEKHATENKVKNLTEEMAGLDETIAKL 995
Query: 317 AEKKYT-----SQGQGDLDSVLSQLNFTHTSEDLLQAEVTCLEGSLESVSATCKQLSQEL 371
+++K Q DL + ++N ++ L+ +V LEGSLE L +
Sbjct: 996 SKEKKALQETHQQTLDDLQAEEDKVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAK 1055
Query: 372 MEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSAL------EGMKMEISHLTQELH 425
+ +LK + + + + ++L E++ + E S+ + + +++++ +EL
Sbjct: 1056 RKLEGDLKLAQESTMDMENDKQQLDEKLEKKEFEISNLISKIEDEQAVEIQLQKKIKELQ 1115
Query: 426 QRDITIASTKGSSSDMEKRLRAEMQK-AEDKAVEHKEILDQLE------SLKLE-NRHLS 477
R G + E+ RA+ +K D + E +EI ++LE S ++E N+
Sbjct: 1116 AR----IEELGEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQVELNKKRE 1171
Query: 478 EMVMKLELGLHEA---KEISLADLQENYIEALNKL---VSENQQLQKDLMNTKSQLEIST 531
KL L EA E +A L++ + +++ +L + Q++++ L KS+L++ T
Sbjct: 1172 AEFQKLRRDLEEATLQHEAMVAALRKKHADSMAELGEQIDNLQRVKQKLEKEKSELKMET 1231
Query: 532 QMCKKQNDRIFKPTHSRTTEFKNTEFKPTHGQHRHDGIKTEHYKTDLHSPRGQASDSINP 591
+ I K + ++ E + + + + + + + DL + R +
Sbjct: 1232 DDLSSNAEAISKAKGNLEKMCRSLEDQVSELKTKEE--EQQRLINDLTAQRARLQTEAGE 1289
Query: 592 MSRVLSPLSPQISPCSSTRSLTSYSL 617
SR L +S S ++ ++ +
Sbjct: 1290 YSRQLDEKDALVSQLSRSKQASTQQI 1315
Score = 55.1 bits (131), Expect = 2e-07
Identities = 83/355 (23%), Positives = 139/355 (39%), Gaps = 70/355 (19%)
Query: 3 ALLEGIQNRGHGGGFLTSCEAELQELMKQIDIMVAHKKSEWE----GRTHALETCLKIRE 58
AL E + H G + + EL ++ ++D +A K E + T +ET +
Sbjct: 1546 ALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQSTLD 1605
Query: 59 QELKSLRSQLDVTHKEVGMLHQ---QVEEHEKIKQEMTMEYKQE---LKKLHEELCILKR 112
E++S L V K G L++ Q+ ++ E Y+ LK+ L R
Sbjct: 1606 AEIRSRNDALRVKKKMEGDLNEMEIQLNHANRLAAESLRNYRNTQGILKETQLHLDDALR 1665
Query: 113 SYEKLQKK-QMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLE 171
E L+++ + E R N ++EIE L A +E+ E+ R I +Q++
Sbjct: 1666 GQEDLKEQLAIVERRANLL-----QAEIEELWATLEQT-------ERSRKIAEQELLDAS 1713
Query: 172 AQRKALAEQSEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERAND---------TICA 222
+ + L Q+ L+N K+KLE+ QSE++ + + A + + A
Sbjct: 1714 ERVQLLHTQN----TSLINTKKKLENDVSQLQSEVEEVIQESRNAEEKAKKAITDAAMMA 1769
Query: 223 NELE--------IERLTMRVNDLVGTSMTVLQEQQQK------------EEKLRESEKLL 262
EL+ +ER+ + V L E +Q E ++RE E +
Sbjct: 1770 EELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEV 1829
Query: 263 EALQEEKRELKAALQSQENLIHEARIQKE--------------KLQEKVKATNTQ 303
E Q+ E L+ E + E Q E KLQ KVK+ Q
Sbjct: 1830 ENEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNVLRLQDLVDKLQAKVKSYKRQ 1884
Score = 42.4 bits (98), Expect = 0.001
Identities = 39/187 (20%), Positives = 90/187 (48%), Gaps = 3/187 (1%)
Query: 20 SCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHK-EVGML 78
+ E + ++ + +M K E + H LE K EQ +K L+ +LD + +
Sbjct: 1753 NAEEKAKKAITDAAMMAEELKKEQDTSAH-LERMKKNLEQTVKDLQHRLDEAEQLALKGG 1811
Query: 79 HQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDRSE 138
+Q+++ E +E+ E + E K+ E + L R +E+ K+ + + KN +
Sbjct: 1812 KKQIQKLEARVRELEGEVENEQKRNAEAVKGL-RKHERRVKELTYQTEEDRKNVLRLQDL 1870
Query: 139 IERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESV 198
+++L AK++ +++++ + E+Q + L+ + + E+++I ++Q+ + K V
Sbjct: 1871 VDKLQAKVKSYKRQAEEAEEQSNANLSKFRKLQHELEEAEERADIAESQVNKLRVKSREV 1930
Query: 199 ELSSQSE 205
+E
Sbjct: 1931 HTKISAE 1937
>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
sapiens]
Length = 1939
Score = 90.9 bits (224), Expect = 4e-18
Identities = 150/719 (20%), Positives = 281/719 (39%), Gaps = 103/719 (14%)
Query: 22 EAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQ 81
E + +L ++++ ++ + E G T A K RE E + +R L+ +
Sbjct: 1137 EKQRSDLSRELE-EISERLEEAGGATSAQIEMNKKREAEFQKMRRDLE----------ES 1185
Query: 82 VEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDRSEIER 141
+HE + ++ + +L E++ L+R +KL+K++ E + EI
Sbjct: 1186 TLQHEATAAALRKKHADSVAELGEQIDSLQRVKQKLEKEKS-----------ELKMEIND 1234
Query: 142 LTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKL--ESVE 199
L + +E + ++EK + Q+S ++ + + EQ +I +L +K +L ES E
Sbjct: 1235 LASNMETVSKAKANFEKMCRTLEDQLSEIKTKEE---EQQRLIN-ELSAQKARLHTESGE 1290
Query: 200 LSSQ-SEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRES 258
S Q E + S+L R E++R T LQ + + LRE
Sbjct: 1291 FSRQLDEKDAMVSQLSRGKQAFTQQIEELKRQLEEETKAKSTLAHALQSARHDCDLLREQ 1350
Query: 259 EKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAIRPREESLAE 318
EE++E KA LQ + K +V T++ +AI+ EE
Sbjct: 1351 -------YEEEQEAKAELQRGMS----------KANSEVAQWRTKYETDAIQRTEELEEA 1393
Query: 319 KKYTSQGQGD----LDSVLSQLNFTHTSEDLLQAEVTCLEGSLESVSATCKQLSQ----- 369
KK +Q D +++V S+ ++ LQ EV L +E +A C L +
Sbjct: 1394 KKKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLMIDVERSNAACIALDKKQRNF 1453
Query: 370 -----ELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSAL---EGMKMEISHLT 421
E +KYEE +A + E + L ++ + + +Y +L E +K E +L
Sbjct: 1454 DKVLAEWKQKYEET---QAELEASQKESRSLSTELFKVKNAYEESLDHLETLKRENKNLQ 1510
Query: 422 QELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMVM 481
QE+ IA ++EK ++K D E E+ LE + H ++
Sbjct: 1511 QEISDLTEQIAEGGKHIHELEK-----VKKQLDH--EKSELQTSLEEAEASLEHEEGKIL 1563
Query: 482 KLELGLHEAK----------EISLADLQENY---IEALNKLVSENQQLQKDLMNTKSQLE 528
+++L L++ K + L L+ N+ +E++ + + + D + K ++E
Sbjct: 1564 RIQLELNQVKSEIDRKIAEKDEELDQLKRNHLRVVESMQSTLDAEIRSRNDALRIKKKME 1623
Query: 529 ISTQMCKKQNDRIFKPTHSRTTEFKNTE--FKPTHGQHRHDGIKTEHYKTDLHSPRGQAS 586
+ Q + + +NT+ K T H D I+ + DL
Sbjct: 1624 GDLNEMEIQLNHANRQAAEALRNLRNTQGILKDTQ-LHLDDAIRGQD---DLKEQLAMVE 1679
Query: 587 DSINPMSRVLSPLSPQISPCSSTRSLTSYSLCKTHSLPSALDTNEANFSDT-------MS 639
N M + L + R + L L T + +T +S
Sbjct: 1680 RRANLMQAEVEELRASLERTERGRKMAEQELLDASERVQLLHTQNTSLINTKKKLETDIS 1739
Query: 640 ESMNDQEEFISSC-SLPVSPLGSIATRFLEEEELRSHHILERLDAHIEELKRESEKTVR 697
+ + E+ + + +I + EEL+ + AH+E +K+ E+TV+
Sbjct: 1740 QIQGEMEDIVQEARNAEEKAKKAITDAAMMAEELKKE---QDTSAHLERMKKNMEQTVK 1795
Score = 90.9 bits (224), Expect = 4e-18
Identities = 123/573 (21%), Positives = 245/573 (42%), Gaps = 42/573 (7%)
Query: 22 EAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQ 81
+AELQ M + + VA ++++E T A++ ++ E + K L +L + V ++ +
Sbjct: 1358 KAELQRGMSKANSEVAQWRTKYE--TDAIQRTEELEEAK-KKLAQRLQDAEEHVEAVNSK 1414
Query: 82 VEEHEKIKQEMTMEYKQELKKLHEE--LCILKRSYEKLQKKQMREFRGNTKNHREDRSEI 139
EK KQ + E + + + CI ++ K + E++ + + E ++E+
Sbjct: 1415 CASLEKTKQRLQNEVEDLMIDVERSNAACIALDKKQRNFDKVLAEWK---QKYEETQAEL 1471
Query: 140 ERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEA---QRKALAEQSEIIQAQLVNRKQ--- 193
E A +E R S + K + Y++ + LE + K L ++ + Q+ +
Sbjct: 1472 E---ASQKESRSLSTELFKVKNAYEESLDHLETLKRENKNLQQEISDLTEQIAEGGKHIH 1528
Query: 194 KLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEE 253
+LE V+ E L + LE A ++ E +I R+ + +N + + E+ ++ +
Sbjct: 1529 ELEKVKKQLDHEKSELQTSLEEAEASLEHEEGKILRIQLELNQVKSEIDRKIAEKDEELD 1588
Query: 254 KLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATN--TQHAVEAIRP 311
+L+ + L ++ + L A ++S+ + + + + L E N + A EA+R
Sbjct: 1589 QLKRNH--LRVVESMQSTLDAEIRSRNDALRIKKKMEGDLNEMEIQLNHANRQAAEALRN 1646
Query: 312 REESLAEKKYTSQGQGDL----DSVLSQLNFTHTSEDLLQAEVTCLEGSLESVSATCKQL 367
+ K T D D + QL +L+QAEV L SLE K
Sbjct: 1647 LRNTQGILKDTQLHLDDAIRGQDDLKEQLAMVERRANLMQAEVEELRASLERTERGRKMA 1706
Query: 368 SQELMEKYEELKRMEAHNNEYKAEIKKLKEQI--LQGE-----QSYSSALEGMKMEISH- 419
QEL++ E ++ + N KKL+ I +QGE Q +A E K I+
Sbjct: 1707 EQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIVQEARNAEEKAKKAITDA 1766
Query: 420 --LTQELHQRDITIASTKGSSSDME---KRLRAEMQKAEDKAVEHKEILDQLESLKLENR 474
+ +EL + T A + +ME K L+ + +AE A++ + Q++ L+ R
Sbjct: 1767 AMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGK--KQIQKLEARVR 1824
Query: 475 HLSEMVMKLELGLHEAKEISLADLQENYIEALNKLVSENQQLQKDLMNTKSQLEISTQMC 534
L V + H + + E ++ L E+++ L + +L+ +
Sbjct: 1825 ELESEVESEQ--KHNVEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQTKVKAY 1882
Query: 535 KKQNDRIFKPTHSRTTEFKNTEFKPTHGQHRHD 567
K+Q + + ++ +F+ + + + R D
Sbjct: 1883 KRQAEEAEEQSNVNLAKFRKLQHELEEAKERAD 1915
Score = 86.7 bits (213), Expect = 7e-17
Identities = 147/744 (19%), Positives = 298/744 (40%), Gaps = 114/744 (15%)
Query: 22 EAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQ 81
E ++ LM++ + + ++E + A E C +L + QL+ KEV ++
Sbjct: 878 EEKMVTLMQEKNDLQLQVQAEADALADAEERC-----DQLIKTKIQLEAKIKEVT---ER 929
Query: 82 VEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQ------KKQMREFRGNTKNHRED 135
E+ E+I E+T + + KL +E LK+ + L+ +K+ KN E+
Sbjct: 930 AEDEEEINAELTAKKR----KLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEE 985
Query: 136 RSEIERLTAKI-------EEFRQKSLD-----------WEKQRLIYQQQVSSLEA---QR 174
+ ++ AK+ +E Q++LD K + +QQV LE Q
Sbjct: 986 MAGLDETIAKLTKEKKALQEAHQQTLDDLQMEEDKVNTLTKAKTKLEQQVDDLEGSLEQE 1045
Query: 175 KALAEQSEIIQAQLV--------------NRKQKLESVELSSQSEIQHLSSKLERANDTI 220
K L E + +L N KQ+L + E+ +L K+E
Sbjct: 1046 KKLCMDLERAKRKLEGDLKLAQESTMDTENDKQQLNEKLKKKEFEMSNLQGKIEDEQALA 1105
Query: 221 CANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQE 280
+ +I+ L R+ +L + + E++ + + LE + E E A +Q
Sbjct: 1106 IQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQI 1165
Query: 281 NLIHEARIQKEKLQEKVKATNTQHAVEAIRPREESLAEKKYTSQGQGDLDSVLSQLNFTH 340
+ + + +K++ ++ + QH A R++ + L V +L
Sbjct: 1166 EMNKKREAEFQKMRRDLEESTLQHEATAAALRKKHADSVAELGEQIDSLQRVKQKL---E 1222
Query: 341 TSEDLLQAEVTCLEGSLESVSAT-------CKQLSQELME---KYEELKRMEAHNNEYKA 390
+ L+ E+ L ++E+VS C+ L +L E K EE +R+ + KA
Sbjct: 1223 KEKSELKMEINDLASNMETVSKAKANFEKMCRTLEDQLSEIKTKEEEQQRLINELSAQKA 1282
Query: 391 EI--------KKLKE------QILQGEQSYSSALEGMKMEISHLTQELHQRDITIASTKG 436
+ ++L E Q+ +G+Q+++ +E +K ++ T+ + S +
Sbjct: 1283 RLHTESGEFSRQLDEKDAMVSQLSRGKQAFTQQIEELKRQLEEETKAKSTLAHALQSARH 1342
Query: 437 SSS------DMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMVMKLELGLHEA 490
+ E+ +AE+Q+ KA E + ++ ++ + + E L EA
Sbjct: 1343 DCDLLREQYEEEQEAKAELQRGMSKA--------NSEVAQWRTKYETDAIQRTE-ELEEA 1393
Query: 491 KEISLADLQ--ENYIEALN----KLVSENQQLQKDLMNTKSQLEISTQMC---KKQNDRI 541
K+ LQ E ++EA+N L Q+LQ ++ + +E S C K+
Sbjct: 1394 KKKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLMIDVERSNAACIALDKKQRNF 1453
Query: 542 FKPTHSRTTEFKNTEFKPTHGQHRHDGIKTEHYKTDLHSPRGQASDSINPMSRVLSPLSP 601
K +++ T+ + Q + TE +K + + ++ D + + R L
Sbjct: 1454 DKVLAEWKQKYEETQAELEASQKESRSLSTELFK--VKNAYEESLDHLETLKRENKNLQQ 1511
Query: 602 QISPCSSTRSLTSYSLCKTHSLPSALDTNEANFSDTMSE---SMNDQEEFISSCSLPVSP 658
+IS + + + + + LD ++ ++ E S+ +E I L ++
Sbjct: 1512 EISDLTEQIAEGGKHIHELEKVKKQLDHEKSELQTSLEEAEASLEHEEGKILRIQLELNQ 1571
Query: 659 LGS-----IATRFLEEEELRSHHI 677
+ S IA + E ++L+ +H+
Sbjct: 1572 VKSEIDRKIAEKDEELDQLKRNHL 1595
Score = 72.4 bits (176), Expect = 1e-12
Identities = 100/467 (21%), Positives = 196/467 (41%), Gaps = 54/467 (11%)
Query: 164 QQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICAN 223
+++++ EA+RK L E+ +V Q+ ++L Q+E L+ ER + I
Sbjct: 864 KEELAKTEAKRKELEEK-------MVTLMQEKNDLQLQVQAEADALADAEERCDQLIKTK 916
Query: 224 ---ELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQE 280
E +I+ +T R D E++ E + KL ++E ELK + E
Sbjct: 917 IQLEAKIKEVTERAED----------EEEINAELTAKKRKL----EDECSELKKDIDDLE 962
Query: 281 NLIHEARIQKEKLQEKVKATNTQHAVEAI-----RPREESLAEKKYTSQGQGDLDSVLSQ 335
+ A+++KEK + K N + + + +E A ++ Q DL +
Sbjct: 963 LTL--AKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQMEEDK 1020
Query: 336 LNFTHTSEDLLQAEVTCLEGSLESVSATCKQLSQELMEKYEELK-----RMEAHNNEYKA 390
+N ++ L+ +V LEGSLE C L + + +LK M+ N++ +
Sbjct: 1021 VNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKLAQESTMDTENDKQQL 1080
Query: 391 EIKKLKEQI----LQGEQSYSSALE-GMKMEISHLTQELHQRDITIASTKGSSSDMEKRL 445
K K++ LQG+ AL ++ +I L + + + I + + S + EK+
Sbjct: 1081 NEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEELEEEIEAERASRAKAEKQ- 1139
Query: 446 RAEMQKAEDKAVEHKEILDQLESLKLE-NRHLSEMVMKLELGL------HEAKEISLADL 498
R+++ + ++ E E S ++E N+ K+ L HEA +L
Sbjct: 1140 RSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEESTLQHEATAAALRKK 1199
Query: 499 QENYIEALNKLVSENQQLQKDLMNTKSQLEISTQMCKKQNDRIFKPTHS-----RTTEFK 553
+ + L + + Q++++ L KS+L++ + + K + RT E +
Sbjct: 1200 HADSVAELGEQIDSLQRVKQKLEKEKSELKMEINDLASNMETVSKAKANFEKMCRTLEDQ 1259
Query: 554 NTEFKPTHGQHRHDGIKTEHYKTDLHSPRGQASDSINPMSRVLSPLS 600
+E K + + + K LH+ G+ S ++ ++S LS
Sbjct: 1260 LSEIKTKEEEQQRLINELSAQKARLHTESGEFSRQLDEKDAMVSQLS 1306
>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
sapiens]
Length = 1939
Score = 90.5 bits (223), Expect = 5e-18
Identities = 150/772 (19%), Positives = 317/772 (41%), Gaps = 128/772 (16%)
Query: 22 EAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQ 81
E ++ LM++ + + ++E + A E C +L + QL+ KEV ++
Sbjct: 878 EEKMVTLMQEKNDLQLQVQAEADSLADAEERC-----DQLIKTKIQLEAKIKEVT---ER 929
Query: 82 VEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQ------KKQMREFRGNTKNHRED 135
E+ E+I E+T + + KL +E LK+ + L+ +K+ KN E+
Sbjct: 930 AEDEEEINAELTAKKR----KLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEE 985
Query: 136 RSEIERLTAKI-------EEFRQKSLD-----------WEKQRLIYQQQVSSLE------ 171
+ ++ AK+ +E Q++LD K ++ +QQV LE
Sbjct: 986 MAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQE 1045
Query: 172 ---------AQRKA-----LAEQSEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERAN 217
A+RK LA++S + + N KQ+L+ + E+ L SK+E
Sbjct: 1046 KKIRMDLERAKRKLEGDLKLAQESTM---DIENDKQQLDEKLKKKEFEMSGLQSKIEDEQ 1102
Query: 218 DTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQ 277
+ +I+ L R+ +L + + E++ + + LE + E E A
Sbjct: 1103 ALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATS 1162
Query: 278 SQENLIHEARIQKEKLQEKVKATNTQHAVEAIRPRE---ESLAE---------------K 319
+Q + + + +K++ ++ QH A R+ +S+AE +
Sbjct: 1163 AQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLE 1222
Query: 320 KYTSQGQGDLDSVLSQLNFTHTSEDLLQAEVTCLEGSLESVSATCKQLSQELMEKYEELK 379
K S+ + ++D + S + ++ L+ LE L + ++ + + + +
Sbjct: 1223 KEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRA 1282
Query: 380 RMEAHNNEYKAEIKK---LKEQILQGEQSYSSALEGMKMEISHLTQELHQRDITIASTKG 436
R++ + EY ++ + L Q+ +G+Q+++ +E +K + L +E+ + + +
Sbjct: 1283 RLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEELKRQ---LEEEIKAKSALAHALQS 1339
Query: 437 SSSDM---------EKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMVMKLELGL 487
S D E+ +AE+Q+A KA E + ++ ++ + + E L
Sbjct: 1340 SRHDCDLLREQYEEEQEAKAELQRAMSKA--------NSEVAQWRTKYETDAIQRTE-EL 1390
Query: 488 HEAKEISLADLQ--ENYIEALN----KLVSENQQLQKDLMNTKSQLEISTQMC----KKQ 537
EAK+ LQ E ++EA+N L Q+LQ ++ + +E + C KKQ
Sbjct: 1391 EEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQ 1450
Query: 538 N--DRIFKPTHSRTTEFKNTEFKPTHGQHRHDGIKTEHYKTDLHSPRGQASDSINPMSRV 595
D+I + E T + Q + TE +K + + ++ D + + R
Sbjct: 1451 RNFDKILAEWKQKCEE---THAELEASQKESRSLSTELFK--IKNAYEESLDQLETLKRE 1505
Query: 596 LSPLSPQISPCSSTRSLTSYSLCKTHSLPSALDTNEANFSDTMSE---SMNDQEEFISSC 652
L +IS + + + + + ++ ++ + E S+ +E I
Sbjct: 1506 NKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAALEEAEASLEHEEGKILRI 1565
Query: 653 SLPVSPLGS-----IATRFLEEEELRSHH--ILERLDAHIEELKRESEKTVR 697
L ++ + S IA + E ++++ +H I+E + + ++ R +R
Sbjct: 1566 QLELNQVKSEVDRKIAEKDEEIDQMKRNHIRIVESMQSTLDAEIRSRNDAIR 1617
Score = 90.1 bits (222), Expect = 6e-18
Identities = 140/719 (19%), Positives = 291/719 (40%), Gaps = 103/719 (14%)
Query: 22 EAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQ 81
E + +L ++++ ++ + E G T A K RE E + +R L+ +
Sbjct: 1137 EKQRSDLSRELE-EISERLEEAGGATSAQIEMNKKREAEFQKMRRDLE----------EA 1185
Query: 82 VEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDRSEIER 141
+HE + ++ + +L E++ L+R +KL+K++ E + EI+
Sbjct: 1186 TLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKS-----------EMKMEIDD 1234
Query: 142 LTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQ-KLESVEL 200
L + +E + + EK + Q+S ++ + + EQ +I R + + ES E
Sbjct: 1235 LASNMETVSKAKGNLEKMCRALEDQLSEIKTKEE---EQQRLINDLTAQRARLQTESGEY 1291
Query: 201 SSQ-SEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESE 259
S Q E L S+L R + T ++ +L ++Q EE+++
Sbjct: 1292 SRQLDEKDTLVSQLSRGK----------QAFTQQIEEL----------KRQLEEEIKAKS 1331
Query: 260 KLLEALQEEKRE---LKAALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAIRPREESL 316
L ALQ + + L+ + ++ E + K +V T++ +AI+ EE
Sbjct: 1332 ALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQRTEELE 1391
Query: 317 AEKKYTSQGQGDLDSVLSQLNFTHTS----EDLLQAEVTCLEGSLESVSATCKQLS---- 368
KK +Q D + + +N S + LQ EV L +E +A C L
Sbjct: 1392 EAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQR 1451
Query: 369 ----------QELMEKYEELKRMEAHNNEYKAEIKKLK---EQILQGEQSYSSALEGMKM 415
Q+ E + EL+ + + E+ K+K E+ L ++ + ++
Sbjct: 1452 NFDKILAEWKQKCEETHAELEASQKESRSLSTELFKIKNAYEESLDQLETLKRENKNLQQ 1511
Query: 416 EISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKA---VEHKEILDQLESLKLE 472
EIS LT+++ + I + +E+ ++E+Q A ++A +EH+E ++ ++LE
Sbjct: 1512 EISDLTEQIAEGGKRIHELEKIKKQVEQE-KSELQAALEEAEASLEHEE--GKILRIQLE 1568
Query: 473 -NRHLSEMVMKL-----ELGLHEAKEISLADLQENYIEALNKLVSENQQLQKDLMNTKSQ 526
N+ SE+ K+ E+ + I + + ++ ++A + ++ +L+K + ++
Sbjct: 1569 LNQVKSEVDRKIAEKDEEIDQMKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNE 1628
Query: 527 LEISTQMCKKQNDRIFKPTHSRTTEFKNTEFKPTHGQHRHDGIKTEHYKTDLHSPRGQAS 586
+EI + + + K+T+ H D ++++ DL
Sbjct: 1629 MEIQLNHANRMAAEALRNYRNTQAILKDTQL------HLDDALRSQE---DLKEQLAMVE 1679
Query: 587 DSINPMSRVLSPLSPQISPCSSTRSLTSYSLCKTHSLPSALDTNEANFSDT-------MS 639
N + + L + +R + L L T + +T +S
Sbjct: 1680 RRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDIS 1739
Query: 640 ESMNDQEEFISSC-SLPVSPLGSIATRFLEEEELRSHHILERLDAHIEELKRESEKTVR 697
+ + E+ I + +I + EEL+ + AH+E +K+ E+TV+
Sbjct: 1740 QIQGEMEDIIQEARNAEEKAKKAITDAAMMAEELKKE---QDTSAHLERMKKNLEQTVK 1795
Score = 87.8 bits (216), Expect = 3e-17
Identities = 127/586 (21%), Positives = 260/586 (44%), Gaps = 68/586 (11%)
Query: 22 EAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQ 81
+AELQ M + + VA ++++E T A++ ++ E + K L +L + V ++ +
Sbjct: 1358 KAELQRAMSKANSEVAQWRTKYE--TDAIQRTEELEEAK-KKLAQRLQDAEEHVEAVNAK 1414
Query: 82 VEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDRSEIER 141
EK KQ + + E++ L ++ + L KKQ R K E + + E
Sbjct: 1415 CASLEKTKQRL----QNEVEDLMIDVERTNAACAALDKKQ----RNFDKILAEWKQKCEE 1466
Query: 142 LTAKIE----EFRQKSLDWEKQRLIYQQ---QVSSLEAQRKALAEQSEIIQAQLVN---R 191
A++E E R S + K + Y++ Q+ +L+ + K L ++ + Q+ R
Sbjct: 1467 THAELEASQKESRSLSTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKR 1526
Query: 192 KQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQK 251
+LE ++ + E L + LE A ++ E +I R+ + +N + + E+ ++
Sbjct: 1527 IHELEKIKKQVEQEKSELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEE 1586
Query: 252 EEKLRESE-KLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATN--TQHAVEA 308
++++ + +++E++Q L A ++S+ + I + + L E N + A EA
Sbjct: 1587 IDQMKRNHIRIVESMQST---LDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEA 1643
Query: 309 IRPREESLAEKKYTSQGQGDL----DSVLSQLNFTHTSEDLLQAEVTCLEGSLESVSATC 364
+R + A K T D + + QL +LLQAE+ L +LE +
Sbjct: 1644 LRNYRNTQAILKDTQLHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSR 1703
Query: 365 KQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQI--LQGE-----QSYSSALEGMKMEI 417
K QEL++ E ++ + N KKL+ I +QGE Q +A E K I
Sbjct: 1704 KIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIIQEARNAEEKAKKAI 1763
Query: 418 SH---LTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENR 474
+ + +EL + T A + ++E+ + K ++H+ LD+ E L L+
Sbjct: 1764 TDAAMMAEELKKEQDTSAHLERMKKNLEQTV---------KDLQHR--LDEAEQLALKGG 1812
Query: 475 HLSEMVMKLELGLHEAKEISLADLQENYIEA----------LNKLVSENQQLQKDLMNTK 524
+ + KLE + E E + Q+ +EA + +L + ++ +K+++ +
Sbjct: 1813 --KKQIQKLEARVREL-EGEVESEQKRNVEAVKGLRKHERKVKELTYQTEEDRKNILRLQ 1869
Query: 525 ---SQLEISTQMCKKQNDRIFKPTHSRTTEFKNTEFKPTHGQHRHD 567
+L+ + K+Q + + ++ ++F+ + + + R D
Sbjct: 1870 DLVDKLQAKVKSYKRQAEEAEEQSNVNLSKFRRIQHELEEAEERAD 1915
Score = 62.8 bits (151), Expect = 1e-09
Identities = 114/540 (21%), Positives = 220/540 (40%), Gaps = 73/540 (13%)
Query: 164 QQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICAN 223
+++++ EA+RK L E+ +V Q+ ++L Q+E L+ ER + I
Sbjct: 864 KEELAKTEAKRKELEEK-------MVTLMQEKNDLQLQVQAEADSLADAEERCDQLIKTK 916
Query: 224 ---ELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQE 280
E +I+ +T R D E++ E + KL ++E ELK + E
Sbjct: 917 IQLEAKIKEVTERAED----------EEEINAELTAKKRKL----EDECSELKKDIDDLE 962
Query: 281 NLIHEARIQKEKLQEKVKATNTQHAVEAI-----RPREESLAEKKYTSQGQGDLDSVLSQ 335
+ A+++KEK + K N + + + +E A ++ Q DL + +
Sbjct: 963 LTL--AKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDK 1020
Query: 336 LNFTHTSEDLLQAEVTCLEGSLESVSATCKQLSQELMEKYEELK-----RMEAHNNEYKA 390
+N ++ L+ +V LEGSLE L + + +LK M+ N++ +
Sbjct: 1021 VNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQL 1080
Query: 391 EIK-KLKEQILQGEQSYSSALEGMKMEISHLTQELHQR----DITIASTKGSSSDMEKRL 445
+ K K KE + G QS + + M++ +EL R + I + + S + EK+
Sbjct: 1081 DEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQ- 1139
Query: 446 RAEMQKAEDKAVEHKEILDQLESLKLE-NRHLSEMVMKLELGLHEA---KEISLADLQEN 501
R+++ + ++ E E S ++E N+ K+ L EA E + A L++
Sbjct: 1140 RSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKK 1199
Query: 502 YIEALNKLVSENQQLQKDLMNTKSQLEISTQMCKKQNDRIFKPTHSRTTEFKNTEFKPTH 561
+ +++ +L + LQ+ K +LE K + D + + + N E
Sbjct: 1200 HADSVAELGEQIDNLQR----VKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRA 1255
Query: 562 GQHRHDGIKTEHYKTDLHSPRGQASDSINPMSRVLSPLSPQISPCSSTRSLTSYSLCKTH 621
+ + IKT+ R+++ L+ Q + + S L +
Sbjct: 1256 LEDQLSEIKTKE----------------EEQQRLINDLTAQRARLQTESGEYSRQLDEKD 1299
Query: 622 SLPSALDTNEANFSDTMSESMNDQEEFISSCSLPVSPLGS-------IATRFLEEEELRS 674
+L S L + F+ + E EE I + S L S + ++ EE+E ++
Sbjct: 1300 TLVSQLSRGKQAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKA 1359
Score = 42.4 bits (98), Expect = 0.001
Identities = 39/187 (20%), Positives = 91/187 (48%), Gaps = 3/187 (1%)
Query: 20 SCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHK-EVGML 78
+ E + ++ + +M K E + H LE K EQ +K L+ +LD + +
Sbjct: 1754 NAEEKAKKAITDAAMMAEELKKEQDTSAH-LERMKKNLEQTVKDLQHRLDEAEQLALKGG 1812
Query: 79 HQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDRSE 138
+Q+++ E +E+ E + E K+ E + L R +E+ K+ + + KN +
Sbjct: 1813 KKQIQKLEARVRELEGEVESEQKRNVEAVKGL-RKHERKVKELTYQTEEDRKNILRLQDL 1871
Query: 139 IERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESV 198
+++L AK++ +++++ + E+Q + + ++ + + E+++I ++Q+ + K V
Sbjct: 1872 VDKLQAKVKSYKRQAEEAEEQSNVNLSKFRRIQHELEEAEERADIAESQVNKLRVKSREV 1931
Query: 199 ELSSQSE 205
SE
Sbjct: 1932 HTKIISE 1938
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.309 0.124 0.325
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,939,599
Number of Sequences: 37866
Number of extensions: 1086240
Number of successful extensions: 18284
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 442
Number of HSP's successfully gapped in prelim test: 1257
Number of HSP's that attempted gapping in prelim test: 6756
Number of HSP's gapped (non-prelim): 5776
length of query: 703
length of database: 18,247,518
effective HSP length: 109
effective length of query: 594
effective length of database: 14,120,124
effective search space: 8387353656
effective search space used: 8387353656
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.