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Search of human proteins with 22035616
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|22035616 oxysterol-binding protein-like protein 7 [Homo
sapiens]
(842 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|22035616 oxysterol-binding protein-like protein 7 [Homo sapiens] 1727 0.0
gi|14210532 oxysterol-binding protein-like protein 6 isoform a [... 839 0.0
gi|22035612 oxysterol-binding protein-like protein 6 isoform b [... 831 0.0
gi|14149704 oxysterol-binding protein-like protein 3 isoform a [... 808 0.0
gi|21735582 oxysterol-binding protein-like protein 3 isoform c [... 802 0.0
gi|21735580 oxysterol-binding protein-like protein 3 isoform b [... 788 0.0
gi|21735584 oxysterol-binding protein-like protein 3 isoform d [... 782 0.0
gi|19718741 oxysterol-binding protein-like 1A isoform B [Homo sa... 286 6e-77
gi|19718746 oxysterol-binding protein-like 1A isoform A [Homo sa... 279 7e-75
gi|21450853 oxysterol-binding protein-like protein 2 isoform 2 [... 278 1e-74
gi|7662298 oxysterol-binding protein-like protein 2 isoform 1 [H... 273 6e-73
gi|4505531 oxysterol binding protein [Homo sapiens] 257 3e-68
gi|13540513 oxysterol binding protein 2 isoform a [Homo sapiens] 253 5e-67
gi|14149740 oxysterol-binding protein-like protein 5 isoform a [... 96 1e-19
gi|221136766 oxysterol-binding protein-like protein 5 isoform b ... 96 1e-19
gi|22035609 oxysterol-binding protein-like protein 5 isoform b [... 96 1e-19
gi|19923812 oxysterol-binding protein-like protein 10 [Homo sapi... 96 2e-19
gi|51243032 oxysterol-binding protein-like protein 8 isoform b [... 94 4e-19
gi|18079218 oxysterol-binding protein-like protein 8 isoform a [... 94 4e-19
gi|20070331 oxysterol binding protein-like 9 isoform e [Homo sap... 86 1e-16
gi|22547176 oxysterol binding protein-like 9 isoform f [Homo sap... 86 1e-16
gi|22547173 oxysterol binding protein-like 9 isoform d [Homo sap... 86 1e-16
gi|22547171 oxysterol binding protein-like 9 isoform c [Homo sap... 86 1e-16
gi|22547169 oxysterol binding protein-like 9 isoform b [Homo sap... 86 1e-16
gi|22547167 oxysterol binding protein-like 9 isoform a [Homo sap... 86 1e-16
gi|22547165 oxysterol binding protein-like 9 isoform a [Homo sap... 86 1e-16
gi|19923592 oxysterol binding protein-like 11 [Homo sapiens] 82 2e-15
gi|217416392 pleckstrin homology domain containing, family H (wi... 47 6e-05
gi|55741447 pleckstrin homology domain containing, family H (wit... 42 0.003
gi|14165452 alpha 3 type IV collagen binding protein isoform 2 [... 41 0.005
>gi|22035616 oxysterol-binding protein-like protein 7 [Homo sapiens]
Length = 842
Score = 1727 bits (4473), Expect = 0.0
Identities = 842/842 (100%), Positives = 842/842 (100%)
Query: 1 MDFQERDPPFLPESAQSSKPSSAQQASELWEVVEEPRVRLGTEGVMPERQEGHLLKKRKW 60
MDFQERDPPFLPESAQSSKPSSAQQASELWEVVEEPRVRLGTEGVMPERQEGHLLKKRKW
Sbjct: 1 MDFQERDPPFLPESAQSSKPSSAQQASELWEVVEEPRVRLGTEGVMPERQEGHLLKKRKW 60
Query: 61 PLKGWHKRYFVLEDGILHYATTRQDITKGKLHGSIDVRLSVMSINKKAQRIDLDTEDNIY 120
PLKGWHKRYFVLEDGILHYATTRQDITKGKLHGSIDVRLSVMSINKKAQRIDLDTEDNIY
Sbjct: 61 PLKGWHKRYFVLEDGILHYATTRQDITKGKLHGSIDVRLSVMSINKKAQRIDLDTEDNIY 120
Query: 121 HLKIKSQDLFQSWVAQLRAHRLAHRLDMPRGSLPSTAHRKVPGAQLPTAATASALPGLGP 180
HLKIKSQDLFQSWVAQLRAHRLAHRLDMPRGSLPSTAHRKVPGAQLPTAATASALPGLGP
Sbjct: 121 HLKIKSQDLFQSWVAQLRAHRLAHRLDMPRGSLPSTAHRKVPGAQLPTAATASALPGLGP 180
Query: 181 REKVSSWLRDSDGLDRCSHELSECQGKLQELHRLLQSLESLHRIPSAPVIPTHQASVTTE 240
REKVSSWLRDSDGLDRCSHELSECQGKLQELHRLLQSLESLHRIPSAPVIPTHQASVTTE
Sbjct: 181 REKVSSWLRDSDGLDRCSHELSECQGKLQELHRLLQSLESLHRIPSAPVIPTHQASVTTE 240
Query: 241 RPKKGKRTSRMWCTQSFAKDDTIGRVGRLHGSVPNLSRYLESRDSSGTRGLPPTDYAHLQ 300
RPKKGKRTSRMWCTQSFAKDDTIGRVGRLHGSVPNLSRYLESRDSSGTRGLPPTDYAHLQ
Sbjct: 241 RPKKGKRTSRMWCTQSFAKDDTIGRVGRLHGSVPNLSRYLESRDSSGTRGLPPTDYAHLQ 300
Query: 301 RSFWALAQKVHSSLSSVLAALTMERDQLRDMHQGSELSRMGVSEASTGQRRLHSLSTSSD 360
RSFWALAQKVHSSLSSVLAALTMERDQLRDMHQGSELSRMGVSEASTGQRRLHSLSTSSD
Sbjct: 301 RSFWALAQKVHSSLSSVLAALTMERDQLRDMHQGSELSRMGVSEASTGQRRLHSLSTSSD 360
Query: 361 TTADSFSSLNPEEQEALYMKGRELTPQLSQTSILSLADSHTEFFDACEVLLSASSSENEG 420
TTADSFSSLNPEEQEALYMKGRELTPQLSQTSILSLADSHTEFFDACEVLLSASSSENEG
Sbjct: 361 TTADSFSSLNPEEQEALYMKGRELTPQLSQTSILSLADSHTEFFDACEVLLSASSSENEG 420
Query: 421 SEEEESCTSEITTSLSEEMLDLRGAERCQKGGCVPGRPMGPPRRRCLPAASGPGADVSLW 480
SEEEESCTSEITTSLSEEMLDLRGAERCQKGGCVPGRPMGPPRRRCLPAASGPGADVSLW
Sbjct: 421 SEEEESCTSEITTSLSEEMLDLRGAERCQKGGCVPGRPMGPPRRRCLPAASGPGADVSLW 480
Query: 481 NILRNNIGKDLSKVSMPVQLNEPLNTLQRLCEELEYSSLLDQASRIADPCERMVYIAAFA 540
NILRNNIGKDLSKVSMPVQLNEPLNTLQRLCEELEYSSLLDQASRIADPCERMVYIAAFA
Sbjct: 481 NILRNNIGKDLSKVSMPVQLNEPLNTLQRLCEELEYSSLLDQASRIADPCERMVYIAAFA 540
Query: 541 VSAYSSTYHRAGCKPFNPVLGETYECERPDRGFRFISEQVSHHPPISACHAESENFAFWQ 600
VSAYSSTYHRAGCKPFNPVLGETYECERPDRGFRFISEQVSHHPPISACHAESENFAFWQ
Sbjct: 541 VSAYSSTYHRAGCKPFNPVLGETYECERPDRGFRFISEQVSHHPPISACHAESENFAFWQ 600
Query: 601 DMKWKNKFWGKSLEIVPVGTVNVSLPRFGDHFEWNKVTSCIHNVLSGQRWIEHYGEVLIR 660
DMKWKNKFWGKSLEIVPVGTVNVSLPRFGDHFEWNKVTSCIHNVLSGQRWIEHYGEVLIR
Sbjct: 601 DMKWKNKFWGKSLEIVPVGTVNVSLPRFGDHFEWNKVTSCIHNVLSGQRWIEHYGEVLIR 660
Query: 661 NTQDSSCHCKITFCKAKYWSSNVHEVQGAVLSRSGRVLHRLFGKWHEGLYRGPTPGGQCI 720
NTQDSSCHCKITFCKAKYWSSNVHEVQGAVLSRSGRVLHRLFGKWHEGLYRGPTPGGQCI
Sbjct: 661 NTQDSSCHCKITFCKAKYWSSNVHEVQGAVLSRSGRVLHRLFGKWHEGLYRGPTPGGQCI 720
Query: 721 WKPNSMPPDHERNFGFTQFALELNELTAELKRSLPSTDTRLRPDQRYLEEGNIQAAEAQK 780
WKPNSMPPDHERNFGFTQFALELNELTAELKRSLPSTDTRLRPDQRYLEEGNIQAAEAQK
Sbjct: 721 WKPNSMPPDHERNFGFTQFALELNELTAELKRSLPSTDTRLRPDQRYLEEGNIQAAEAQK 780
Query: 781 RRIEQLQRDRRKVMEENNIVHQARFFRRQTDSSGKEWWVTNNTYWRLRAEPGYGNMDGAV 840
RRIEQLQRDRRKVMEENNIVHQARFFRRQTDSSGKEWWVTNNTYWRLRAEPGYGNMDGAV
Sbjct: 781 RRIEQLQRDRRKVMEENNIVHQARFFRRQTDSSGKEWWVTNNTYWRLRAEPGYGNMDGAV 840
Query: 841 LW 842
LW
Sbjct: 841 LW 842
>gi|14210532 oxysterol-binding protein-like protein 6 isoform a
[Homo sapiens]
Length = 934
Score = 839 bits (2168), Expect = 0.0
Identities = 441/890 (49%), Positives = 583/890 (65%), Gaps = 60/890 (6%)
Query: 9 PFLPESAQSSKPSSAQQASELWEVVEEPRVRLGTEGVM-PERQEGHLLKKRKWPLKGWHK 67
P + +P + ++ WE++E +++G V P++ EG +LKKRKWPLKGWHK
Sbjct: 49 PSVSRQLLEPEPVPLSKEADSWEIIEG--LKIGQTNVQKPDKHEGFMLKKRKWPLKGWHK 106
Query: 68 RYFVLEDGILHYATTRQDITKGKLHGSIDVRLSVMSINKKAQRIDLDTEDNIYHLKIKSQ 127
R+FVL++G+L Y+ DI KGK+HGSIDV LSVMSI KKA+RIDLDTE++IYHLK+KSQ
Sbjct: 107 RFFVLDNGMLKYSKAPLDIQKGKVHGSIDVGLSVMSIKKKARRIDLDTEEHIYHLKVKSQ 166
Query: 128 DLFQSWVAQLRAHRLAHRLDMPRGSLPSTAH--RKVPGAQLPTAATASALPG-LGP---- 180
D F +WV++LR HRL + ++ R ++ H A+ AA S + G + P
Sbjct: 167 DWFDAWVSKLRHHRLYRQNEIVRSPRDASFHIFPSTSTAESSPAANVSVMDGKMQPNSFP 226
Query: 181 ------------------REKVSSWLRDSDGLDRCSHELSECQGKLQELHRLLQSLESLH 222
+ KV++WL+DS+ +DRC+ +L+ CQ L EL +LLQ+LE L
Sbjct: 227 WQSPLPCSNSLPATCTTGQSKVAAWLQDSEEMDRCAEDLAHCQSNLVELSKLLQNLEILQ 286
Query: 223 RIPSAPVIPTHQASVTTERPKKGKRTSRMWCTQSFAKDDTIG---------RVGRLHGSV 273
R SAP QA+ + KK KR +R W T+S +KD I RLH S
Sbjct: 287 RTQSAPNFTDMQANCV-DISKKDKRVTRRWRTKSVSKDTKIQLQVPFSATMSPVRLHSSN 345
Query: 274 PNLSRYLESRDSSGTRGLP---PTDYAHLQRSFWALAQKVHSSLSSVLAALTMERDQLRD 330
PNL +E + P TDY LQ F +AQKVHS L S ++ +E+++L+
Sbjct: 346 PNLCADIEFQTPPSHLTDPLESSTDYTKLQEEFCLIAQKVHSLLKSAFNSIAIEKEKLKQ 405
Query: 331 M-----HQGSELSRMGVSEASTGQ------------RRLHSLSTSSDTTADSFSSLNPEE 373
M H ++M S Q R+HS S D +P+E
Sbjct: 406 MVSEQDHSKGHSTQMARLRQSLSQALNQNAELRSRLNRIHSESIICDQVVSVNIIPSPDE 465
Query: 374 QEALYMKGRELTPQLSQTSILSLADSHTEFFDACEVLLSASSSENEGSEEEESCTSEITT 433
L+ Q++ S LS+++S +EFFDA EVLLSASSSENE S++E S S+++
Sbjct: 466 AGEQIHVSLPLSQQVANESRLSMSESVSEFFDAQEVLLSASSSENEASDDE-SYISDVSD 524
Query: 434 SLSEEMLDLR-GAERCQKGGCVPGRPMGPPRRRCLPAASGPGADVSLWNILRNNIGKDLS 492
++SE+ + R G + G RR CLPA ++++LWNILRNNIGKDLS
Sbjct: 525 NISEDNTSVADNISRQILNGELTGGAFRNGRRACLPAPCPDTSNINLWNILRNNIGKDLS 584
Query: 493 KVSMPVQLNEPLNTLQRLCEELEYSSLLDQASRIADPCERMVYIAAFAVSAYSSTYHRAG 552
KVSMPV+LNEPLNTLQ LCEE+EYS LLD+AS DP ERMV +AAFAVS Y STY RAG
Sbjct: 585 KVSMPVELNEPLNTLQHLCEEMEYSELLDKASETDDPYERMVLVAAFAVSGYCSTYFRAG 644
Query: 553 CKPFNPVLGETYECERPDRGFRFISEQVSHHPPISACHAESENFAFWQDMKWKNKFWGKS 612
KPFNPVLGETYEC R D+GFRF SEQVSHHPPISACH ES+NF FWQD++WKNKFWGKS
Sbjct: 645 SKPFNPVLGETYECIREDKGFRFFSEQVSHHPPISACHCESKNFVFWQDIRWKNKFWGKS 704
Query: 613 LEIVPVGTVNVSLPRFGDHFEWNKVTSCIHNVLSGQRWIEHYGEVLIRNTQDSSCHCKIT 672
+EI+PVGT+NV LP++GD++ WNKVT+CIHN+LSG+RWIEHYGEV IRNT+ S C CK+T
Sbjct: 705 MEILPVGTLNVMLPKYGDYYVWNKVTTCIHNILSGRRWIEHYGEVTIRNTKSSVCICKLT 764
Query: 673 FCKAKYWSSNVHEVQGAVLSRSGRVLHRLFGKWHEGLYRGPTPGGQCIWKPNSMPPDHER 732
F K YW+SN++EVQG V+ + G+ ++RLFGKWHEGLY G P +CIW+P SMP ++E
Sbjct: 765 FVKVNYWNSNMNEVQGVVIDQEGKAVYRLFGKWHEGLYCGVAPSAKCIWRPGSMPTNYEL 824
Query: 733 NFGFTQFALELNELTAELKRSLPSTDTRLRPDQRYLEEGNIQAAEAQKRRIEQLQRDRRK 792
+GFT+FA+ELNEL LK LP TD R RPDQR+LEEGN++AA ++K+R+E+LQR RR+
Sbjct: 825 YYGFTRFAIELNELDPVLKDLLPPTDARFRPDQRFLEEGNLEAAASEKQRVEELQRSRRR 884
Query: 793 VMEENNIVHQARFFRRQTDSSGKEWWVTNNTYWRLRAEPGYGNMDGAVLW 842
MEENN+ H +FF++ D++ +E WV+N+TYW LR +PG+ +D VLW
Sbjct: 885 YMEENNLEHIPKFFKKVIDANQREAWVSNDTYWELRKDPGFSKVDSPVLW 934
>gi|22035612 oxysterol-binding protein-like protein 6 isoform b
[Homo sapiens]
Length = 938
Score = 831 bits (2146), Expect = 0.0
Identities = 442/915 (48%), Positives = 585/915 (63%), Gaps = 85/915 (9%)
Query: 9 PFLPESAQSSKPSSAQQASELWEVVEEPRVRLGTEGVM-PERQEGHLLKKRKWPLKGWHK 67
P + +P + ++ WE++E +++G V P++ EG +LKKRKWPLKGWHK
Sbjct: 28 PSVSRQLLEPEPVPLSKEADSWEIIEG--LKIGQTNVQKPDKHEGFMLKKRKWPLKGWHK 85
Query: 68 RYFVLEDGILHYATTRQDITKGKLHGSIDVRLSVMSINKKAQRIDLDTEDNIYHLKIKSQ 127
R+FVL++G+L Y+ DI KGK+HGSIDV LSVMSI KKA+RIDLDTE++IYHLK+KSQ
Sbjct: 86 RFFVLDNGMLKYSKAPLDIQKGKVHGSIDVGLSVMSIKKKARRIDLDTEEHIYHLKVKSQ 145
Query: 128 DLFQSWVAQLRAHRLAHRLDMPRGSLPSTAH--RKVPGAQLPTAATASALPG-LGP---- 180
D F +WV++LR HRL + ++ R ++ H A+ AA S + G + P
Sbjct: 146 DWFDAWVSKLRHHRLYRQNEIVRSPRDASFHIFPSTSTAESSPAANVSVMDGKMQPNSFP 205
Query: 181 ------------------REKVSSWLRDSDGLDRCSHELSECQGKLQELHRLLQSLESLH 222
+ KV++WL+DS+ +DRC+ +L+ CQ L EL +LLQ+LE L
Sbjct: 206 WQSPLPCSNSLPATCTTGQSKVAAWLQDSEEMDRCAEDLAHCQSNLVELSKLLQNLEILQ 265
Query: 223 RIPSAPVIPTHQASVTTERPKKGKRTSRMWCTQSFAKDDTI---------GRVG------ 267
R SAP QA+ + KK KR +R W T+S +KD I G+
Sbjct: 266 RTQSAPNFTDMQANCV-DISKKDKRVTRRWRTKSVSKDTKIQLQEGPPAKGQFSTTRRRQ 324
Query: 268 -------------------RLHGSVPNLSRYLESRDSSGTRGLP---PTDYAHLQRSFWA 305
RLH S PNL +E + P TDY LQ F
Sbjct: 325 RLAAAVATTVPFSATMSPVRLHSSNPNLCADIEFQTPPSHLTDPLESSTDYTKLQEEFCL 384
Query: 306 LAQKVHSSLSSVLAALTMERDQLRDM-----HQGSELSRMGVSEASTGQ----------- 349
+AQKVHS L S ++ +E+++L+ M H ++M S Q
Sbjct: 385 IAQKVHSLLKSAFNSIAIEKEKLKQMVSEQDHSKGHSTQMARLRQSLSQALNQNAELRSR 444
Query: 350 -RRLHSLSTSSDTTADSFSSLNPEEQEALYMKGRELTPQLSQTSILSLADSHTEFFDACE 408
R+HS S D +P+E L+ Q++ S LS+++S +EFFDA E
Sbjct: 445 LNRIHSESIICDQVVSVNIIPSPDEAGEQIHVSLPLSQQVANESRLSMSESVSEFFDAQE 504
Query: 409 VLLSASSSENEGSEEEESCTSEITTSLSEEMLDLR-GAERCQKGGCVPGRPMGPPRRRCL 467
VLLSASSSENE S++E S S+++ ++SE+ + R G + G RR CL
Sbjct: 505 VLLSASSSENEASDDE-SYISDVSDNISEDNTSVADNISRQILNGELTGGAFRNGRRACL 563
Query: 468 PAASGPGADVSLWNILRNNIGKDLSKVSMPVQLNEPLNTLQRLCEELEYSSLLDQASRIA 527
PA ++++LWNILRNNIGKDLSKVSMPV+LNEPLNTLQ LCEE+EYS LLD+AS
Sbjct: 564 PAPCPDTSNINLWNILRNNIGKDLSKVSMPVELNEPLNTLQHLCEEMEYSELLDKASETD 623
Query: 528 DPCERMVYIAAFAVSAYSSTYHRAGCKPFNPVLGETYECERPDRGFRFISEQVSHHPPIS 587
DP ERMV +AAFAVS Y STY RAG KPFNPVLGETYEC R D+GFRF SEQVSHHPPIS
Sbjct: 624 DPYERMVLVAAFAVSGYCSTYFRAGSKPFNPVLGETYECIREDKGFRFFSEQVSHHPPIS 683
Query: 588 ACHAESENFAFWQDMKWKNKFWGKSLEIVPVGTVNVSLPRFGDHFEWNKVTSCIHNVLSG 647
ACH ES+NF FWQD++WKNKFWGKS+EI+PVGT+NV LP++GD++ WNKVT+CIHN+LSG
Sbjct: 684 ACHCESKNFVFWQDIRWKNKFWGKSMEILPVGTLNVMLPKYGDYYVWNKVTTCIHNILSG 743
Query: 648 QRWIEHYGEVLIRNTQDSSCHCKITFCKAKYWSSNVHEVQGAVLSRSGRVLHRLFGKWHE 707
+RWIEHYGEV IRNT+ S C CK+TF K YW+SN++EVQG V+ + G+ ++RLFGKWHE
Sbjct: 744 RRWIEHYGEVTIRNTKSSVCICKLTFVKVNYWNSNMNEVQGVVIDQEGKAVYRLFGKWHE 803
Query: 708 GLYRGPTPGGQCIWKPNSMPPDHERNFGFTQFALELNELTAELKRSLPSTDTRLRPDQRY 767
GLY G P +CIW+P SMP ++E +GFT+FA+ELNEL LK LP TD R RPDQR+
Sbjct: 804 GLYCGVAPSAKCIWRPGSMPTNYELYYGFTRFAIELNELDPVLKDLLPPTDARFRPDQRF 863
Query: 768 LEEGNIQAAEAQKRRIEQLQRDRRKVMEENNIVHQARFFRRQTDSSGKEWWVTNNTYWRL 827
LEEGN++AA ++K+R+E+LQR RR+ MEENN+ H +FF++ D++ +E WV+N+TYW L
Sbjct: 864 LEEGNLEAAASEKQRVEELQRSRRRYMEENNLEHIPKFFKKVIDANQREAWVSNDTYWEL 923
Query: 828 RAEPGYGNMDGAVLW 842
R +PG+ +D VLW
Sbjct: 924 RKDPGFSKVDSPVLW 938
>gi|14149704 oxysterol-binding protein-like protein 3 isoform a
[Homo sapiens]
Length = 887
Score = 808 bits (2086), Expect = 0.0
Identities = 436/886 (49%), Positives = 567/886 (63%), Gaps = 70/886 (7%)
Query: 12 PESAQSSKPSSAQQASELWEVVEEPRVRLGTEGVM-----PERQEGHLLKKRKWPLKGWH 66
P + SS S + WEVVE G G M P Q+G LLKKRKWPLKGWH
Sbjct: 17 PSRSTSSCSSKQGSRQDSWEVVE------GLRGEMNYTQEPPVQKGFLLKKRKWPLKGWH 70
Query: 67 KRYFVLEDGILHYATTRQDITKGKLHGSIDVRLSVMSINKKAQRIDLDTEDNIYHLKIKS 126
KR+F L+ GIL YA ++ DI + KLHG IDV LSVMS+ K ++ IDLDTE++IYHLK+KS
Sbjct: 71 KRFFYLDKGILKYAKSQTDIEREKLHGCIDVGLSVMSVKKSSKCIDLDTEEHIYHLKVKS 130
Query: 127 QDLFQSWVAQLRAHRLAHR-------------------LDMPRGSLPSTAHRKVPGAQ-- 165
+++F WV++LR HR+ + D G S + RK
Sbjct: 131 EEVFDEWVSKLRHHRMYRQNEIAMFPHEVNHFFSGSTITDSSSGVFDSISSRKRSSISKQ 190
Query: 166 --LPTAATASALPGLGPREKVSSWLRDSDGLDRCSHELSECQGKLQELHRLLQSLESLHR 223
T + S G +V WL+ S+ +++CS +L+ C L E+ +LLQS++ LHR
Sbjct: 191 NLFQTGSNVSF--SCGGETRVPLWLQSSEDMEKCSKDLAHCHAYLVEMSQLLQSMDVLHR 248
Query: 224 IPSAPVIPTHQASVTTERPKKGKRTSRMWCTQSFAKD--------DTIGRVGRLHGSVPN 275
SAP I Q + E PKK KR+ R W +++ KD RLH S PN
Sbjct: 249 TYSAPAINAIQGG-SFESPKKEKRSHRRWRSRAIGKDAKGTLQVPKPFSGPVRLHSSNPN 307
Query: 276 LSRYLESRDSSGTRGLPPT-DYAHLQRSFWALAQKVHSSLSSVLAALTMERDQLRDMHQG 334
LS + + + G + +++ +Q +A KV+ +L S ++ ER++L+ + +
Sbjct: 308 LSTLDFGEEKNYSDGSETSSEFSKMQEDLCHIAHKVYFTLRSAFNIMSAEREKLKQLMEQ 367
Query: 335 SELSR-----MGVSEASTGQ-----------RRLHSLSTSSDTTADSFSSLNPEEQEALY 378
S +G+ A + RR+H+ S D+ A + S N E+ +
Sbjct: 368 DASSSPSAQVIGLKNALSSALAQNTDLKERLRRIHAESLLLDSPAVAKSGDNLAEENSRD 427
Query: 379 MKGRELTPQLSQTSILSLADSHTEFFDACEVLLSASSSENEGSEEEESCTSEITTSLSEE 438
+ R L QLS S LS+ DS +EFFDA EVLLS SSSENE S+++ S S+I+ +LS +
Sbjct: 428 -ENRALVHQLSNESRLSITDSLSEFFDAQEVLLSPSSSENEISDDD-SYVSDISDNLSLD 485
Query: 439 ML--DLRGAERCQKGGCVPGRPMGPPRRRCLPAASGPGADVSLWNILRNNIGKDLSKVSM 496
L DL + GR RR CLPA +++SLWNILRNNIGKDLSKV+M
Sbjct: 486 NLSNDLDNERQTLGPVLDSGREAKSRRRTCLPAPCPSSSNISLWNILRNNIGKDLSKVAM 545
Query: 497 PVQLNEPLNTLQRLCEELEYSSLLDQASRIADPCERMVYIAAFAVSAYSSTYHRAGCKPF 556
PV+LNEPLNTLQRLCEELEYS LLD+A++I P ERMVY+AAFA+SAY+S+Y+RAG KPF
Sbjct: 546 PVELNEPLNTLQRLCEELEYSELLDKAAQIPSPLERMVYVAAFAISAYASSYYRAGSKPF 605
Query: 557 NPVLGETYECERPDRGFRFISEQVSHHPPISACHAESENFAFWQDMKWKNKFWGKSLEIV 616
NPVLGETYEC R D+GF+F SEQVSHHPPISACHAES NF FWQD++WKNKFWGKS+EIV
Sbjct: 606 NPVLGETYECIREDKGFQFFSEQVSHHPPISACHAESRNFVFWQDVRWKNKFWGKSMEIV 665
Query: 617 PVGTVNVSLPRFGDHFEWNKVTSCIHNVLSGQRWIEHYGEVLIRNTQDSSCHCKITFCKA 676
P+GT +V+LP FGDHFEWNKVTSCIHN+LSGQRWIEHYGE++I+N D SC+CK+ F KA
Sbjct: 666 PIGTTHVTLPVFGDHFEWNKVTSCIHNILSGQRWIEHYGEIVIKNLHDDSCYCKVNFIKA 725
Query: 677 KYWSSNVHEVQGAVLSRSGRVLHRLFGKWHEGLYRGPTPGGQCIWKPNSMPPDHERNFGF 736
KYWS+N HE++G V RSG+ +HRLFGKWHE +Y G C+W+ N MP +E+ + F
Sbjct: 726 KYWSTNAHEIEGTVFDRSGKAVHRLFGKWHESIYCGGGSSSACVWRANPMPKGYEQYYSF 785
Query: 737 TQFALELNELTAELKRSLPSTDTRLRPDQRYLEEGNIQAAEAQKRRIEQLQRDRRKVMEE 796
TQFALELNE+ K LP TDTR RPDQR+LEEGN++ AE QK+RIEQLQR+RR+V+EE
Sbjct: 786 TQFALELNEMDPSSKSLLPPTDTRFRPDQRFLEEGNLEEAEIQKQRIEQLQRERRRVLEE 845
Query: 797 NNIVHQARFFRRQTDSSGKEWWVTNNTYWRLRAEPGYGNMDGAVLW 842
N++ HQ RFFR+ D S WV+N TY LR + G+ +D VLW
Sbjct: 846 NHVEHQPRFFRKSDDDS----WVSNGTYLELRKDLGFSKLDHPVLW 887
>gi|21735582 oxysterol-binding protein-like protein 3 isoform c
[Homo sapiens]
Length = 851
Score = 802 bits (2072), Expect = 0.0
Identities = 430/870 (49%), Positives = 552/870 (63%), Gaps = 74/870 (8%)
Query: 12 PESAQSSKPSSAQQASELWEVVEEPRVRLGTEGVM-----PERQEGHLLKKRKWPLKGWH 66
P + SS S + WEVVE G G M P Q+G LLKKRKWPLKGWH
Sbjct: 17 PSRSTSSCSSKQGSRQDSWEVVE------GLRGEMNYTQEPPVQKGFLLKKRKWPLKGWH 70
Query: 67 KRYFVLEDGILHYATTRQDITKGKLHGSIDVRLSVMSINKKAQRIDLDTEDNIYHLKIKS 126
KR+F L+ GIL YA ++ DI + KLHG IDV LSVMS+ K ++ IDLDTE++IYHLK+KS
Sbjct: 71 KRFFYLDKGILKYAKSQTDIEREKLHGCIDVGLSVMSVKKSSKCIDLDTEEHIYHLKVKS 130
Query: 127 QDLFQSWVAQLRAHRLAHR-------------------LDMPRGSLPSTAHRKVPGAQ-- 165
+++F WV++LR HR+ + D G S + RK
Sbjct: 131 EEVFDEWVSKLRHHRMYRQNEIAMFPHEVNHFFSGSTITDSSSGVFDSISSRKRSSISKQ 190
Query: 166 --LPTAATASALPGLGPREKVSSWLRDSDGLDRCSHELSECQGKLQELHRLLQSLESLHR 223
T + S G +V WL+ S+ +++CS +L+ C L E+ +LLQS++ LHR
Sbjct: 191 NLFQTGSNVSF--SCGGETRVPLWLQSSEDMEKCSKDLAHCHAYLVEMSQLLQSMDVLHR 248
Query: 224 IPSAPVIPTHQASVTTERPKKGKRTSRMWCTQSFAKD--------DTIGRVGRLHGSVPN 275
SAP I Q + E PKK KR+ R W +++ KD RLH S PN
Sbjct: 249 TYSAPAINAIQGG-SFESPKKEKRSHRRWRSRAIGKDAKGTLQVPKPFSGPVRLHSSNPN 307
Query: 276 LSRYLESRDSSGTRGLPPT-DYAHLQRSFWALAQKVHSSLSSVLAALTMERDQLRDMHQG 334
LS + + + G + +++ +Q +A KV+ +L S ++ ER++L+
Sbjct: 308 LSTLDFGEEKNYSDGSETSSEFSKMQEDLCHIAHKVYFTLRSAFNIMSAEREKLK----- 362
Query: 335 SELSRMGVSEASTGQRRLHSLSTSSDTTADSFSSLNPEEQEALYMKGRELTPQLSQTSIL 394
+L SS +A N E + R L QLS S L
Sbjct: 363 ----------------QLMEQDASSSPSAQVIGLKNALSSENSRDENRALVHQLSNESRL 406
Query: 395 SLADSHTEFFDACEVLLSASSSENEGSEEEESCTSEITTSLSEEML--DLRGAERCQKGG 452
S+ DS +EFFDA EVLLS SSSENE S+++ S S+I+ +LS + L DL +
Sbjct: 407 SITDSLSEFFDAQEVLLSPSSSENEISDDD-SYVSDISDNLSLDNLSNDLDNERQTLGPV 465
Query: 453 CVPGRPMGPPRRRCLPAASGPGADVSLWNILRNNIGKDLSKVSMPVQLNEPLNTLQRLCE 512
GR RR CLPA +++SLWNILRNNIGKDLSKV+MPV+LNEPLNTLQRLCE
Sbjct: 466 LDSGREAKSRRRTCLPAPCPSSSNISLWNILRNNIGKDLSKVAMPVELNEPLNTLQRLCE 525
Query: 513 ELEYSSLLDQASRIADPCERMVYIAAFAVSAYSSTYHRAGCKPFNPVLGETYECERPDRG 572
ELEYS LLD+A++I P ERMVY+AAFA+SAY+S+Y+RAG KPFNPVLGETYEC R D+G
Sbjct: 526 ELEYSELLDKAAQIPSPLERMVYVAAFAISAYASSYYRAGSKPFNPVLGETYECIREDKG 585
Query: 573 FRFISEQVSHHPPISACHAESENFAFWQDMKWKNKFWGKSLEIVPVGTVNVSLPRFGDHF 632
F+F SEQVSHHPPISACHAES NF FWQD++WKNKFWGKS+EIVP+GT +V+LP FGDHF
Sbjct: 586 FQFFSEQVSHHPPISACHAESRNFVFWQDVRWKNKFWGKSMEIVPIGTTHVTLPVFGDHF 645
Query: 633 EWNKVTSCIHNVLSGQRWIEHYGEVLIRNTQDSSCHCKITFCKAKYWSSNVHEVQGAVLS 692
EWNKVTSCIHN+LSGQRWIEHYGE++I+N D SC+CK+ F KAKYWS+N HE++G V
Sbjct: 646 EWNKVTSCIHNILSGQRWIEHYGEIVIKNLHDDSCYCKVNFIKAKYWSTNAHEIEGTVFD 705
Query: 693 RSGRVLHRLFGKWHEGLYRGPTPGGQCIWKPNSMPPDHERNFGFTQFALELNELTAELKR 752
RSG+ +HRLFGKWHE +Y G C+W+ N MP +E+ + FTQFALELNE+ K
Sbjct: 706 RSGKAVHRLFGKWHESIYCGGGSSSACVWRANPMPKGYEQYYSFTQFALELNEMDPSSKS 765
Query: 753 SLPSTDTRLRPDQRYLEEGNIQAAEAQKRRIEQLQRDRRKVMEENNIVHQARFFRRQTDS 812
LP TDTR RPDQR+LEEGN++ AE QK+RIEQLQR+RR+V+EEN++ HQ RFFR+ D
Sbjct: 766 LLPPTDTRFRPDQRFLEEGNLEEAEIQKQRIEQLQRERRRVLEENHVEHQPRFFRKSDDD 825
Query: 813 SGKEWWVTNNTYWRLRAEPGYGNMDGAVLW 842
S WV+N TY LR + G+ +D VLW
Sbjct: 826 S----WVSNGTYLELRKDLGFSKLDHPVLW 851
>gi|21735580 oxysterol-binding protein-like protein 3 isoform b
[Homo sapiens]
Length = 856
Score = 788 bits (2034), Expect = 0.0
Identities = 427/878 (48%), Positives = 553/878 (62%), Gaps = 85/878 (9%)
Query: 12 PESAQSSKPSSAQQASELWEVVEEPRVRLGTEGVM-----PERQEGHLLKKRKWPLKGWH 66
P + SS S + WEVVE G G M P Q+G LLKKRKWPLKGWH
Sbjct: 17 PSRSTSSCSSKQGSRQDSWEVVE------GLRGEMNYTQEPPVQKGFLLKKRKWPLKGWH 70
Query: 67 KRYFVLEDGILHYATTRQDITKGKLHGSIDVRLSVMSINKKAQRIDLDTEDNIYHLKIKS 126
KR+F L+ GIL YA ++ DI + KLHG IDV LSVMS+ K ++ IDLDTE++IYHLK+KS
Sbjct: 71 KRFFYLDKGILKYAKSQTDIEREKLHGCIDVGLSVMSVKKSSKCIDLDTEEHIYHLKVKS 130
Query: 127 QDLFQSWVAQLRAHRLAHR-------------------LDMPRGSLPSTAHRKVPGAQ-- 165
+++F WV++LR HR+ + D G S + RK
Sbjct: 131 EEVFDEWVSKLRHHRMYRQNEIAMFPHEVNHFFSGSTITDSSSGVFDSISSRKRSSISKQ 190
Query: 166 --LPTAATASALPGLGPREKVSSWLRDSDGLDRCSHELSECQGKLQELHRLLQSLESLHR 223
T + S G +V WL+ S+ +++CS +L+ C L E+ +LLQS++ LHR
Sbjct: 191 NLFQTGSNVSF--SCGGETRVPLWLQSSEDMEKCSKDLAHCHAYLVEMSQLLQSMDVLHR 248
Query: 224 IPSAPVIPTHQASVTTERPKKGKRTSRMWCTQSFAKDDTIGRVGRLHGSVPNLSRYLESR 283
SAP I Q P RLH S PNLS
Sbjct: 249 TYSAPAINAIQVPKPFSGPV------------------------RLHSSNPNLSTLDFGE 284
Query: 284 DSSGTRGLPPT-DYAHLQRSFWALAQKVHSSLSSVLAALTMERDQLRDMHQGSELSR--- 339
+ + + G + +++ +Q +A KV+ +L S ++ ER++L+ + + S
Sbjct: 285 EKNYSDGSETSSEFSKMQEDLCHIAHKVYFTLRSAFNIMSAEREKLKQLMEQDASSSPSA 344
Query: 340 --MGVSEASTGQ-----------RRLHSLSTSSDTTADSFSSLNPEEQEALYMKGRELTP 386
+G+ A + RR+H+ S D+ A + S N E+ + + R L
Sbjct: 345 QVIGLKNALSSALAQNTDLKERLRRIHAESLLLDSPAVAKSGDNLAEENSRD-ENRALVH 403
Query: 387 QLSQTSILSLADSHTEFFDACEVLLSASSSENEGSEEEESCTSEITTSLSEEML--DLRG 444
QLS S LS+ DS +EFFDA EVLLS SSSENE S+++ S S+I+ +LS + L DL
Sbjct: 404 QLSNESRLSITDSLSEFFDAQEVLLSPSSSENEISDDD-SYVSDISDNLSLDNLSNDLDN 462
Query: 445 AERCQKGGCVPGRPMGPPRRRCLPAASGPGADVSLWNILRNNIGKDLSKVSMPVQLNEPL 504
+ GR RR CLPA +++SLWNILRNNIGKDLSKV+MPV+LNEPL
Sbjct: 463 ERQTLGPVLDSGREAKSRRRTCLPAPCPSSSNISLWNILRNNIGKDLSKVAMPVELNEPL 522
Query: 505 NTLQRLCEELEYSSLLDQASRIADPCERMVYIAAFAVSAYSSTYHRAGCKPFNPVLGETY 564
NTLQRLCEELEYS LLD+A++I P ERMVY+AAFA+SAY+S+Y+RAG KPFNPVLGETY
Sbjct: 523 NTLQRLCEELEYSELLDKAAQIPSPLERMVYVAAFAISAYASSYYRAGSKPFNPVLGETY 582
Query: 565 ECERPDRGFRFISEQVSHHPPISACHAESENFAFWQDMKWKNKFWGKSLEIVPVGTVNVS 624
EC R D+GF+F SEQVSHHPPISACHAES NF FWQD++WKNKFWGKS+EIVP+GT +V+
Sbjct: 583 ECIREDKGFQFFSEQVSHHPPISACHAESRNFVFWQDVRWKNKFWGKSMEIVPIGTTHVT 642
Query: 625 LPRFGDHFEWNKVTSCIHNVLSGQRWIEHYGEVLIRNTQDSSCHCKITFCKAKYWSSNVH 684
LP FGDHFEWNKVTSCIHN+LSGQRWIEHYGE++I+N D SC+CK+ F KAKYWS+N H
Sbjct: 643 LPVFGDHFEWNKVTSCIHNILSGQRWIEHYGEIVIKNLHDDSCYCKVNFIKAKYWSTNAH 702
Query: 685 EVQGAVLSRSGRVLHRLFGKWHEGLYRGPTPGGQCIWKPNSMPPDHERNFGFTQFALELN 744
E++G V RSG+ +HRLFGKWHE +Y G C+W+ N MP +E+ + FTQFALELN
Sbjct: 703 EIEGTVFDRSGKAVHRLFGKWHESIYCGGGSSSACVWRANPMPKGYEQYYSFTQFALELN 762
Query: 745 ELTAELKRSLPSTDTRLRPDQRYLEEGNIQAAEAQKRRIEQLQRDRRKVMEENNIVHQAR 804
E+ K LP TDTR RPDQR+LEEGN++ AE QK+RIEQLQR+RR+V+EEN++ HQ R
Sbjct: 763 EMDPSSKSLLPPTDTRFRPDQRFLEEGNLEEAEIQKQRIEQLQRERRRVLEENHVEHQPR 822
Query: 805 FFRRQTDSSGKEWWVTNNTYWRLRAEPGYGNMDGAVLW 842
FFR+ D S WV+N TY LR + G+ +D VLW
Sbjct: 823 FFRKSDDDS----WVSNGTYLELRKDLGFSKLDHPVLW 856
>gi|21735584 oxysterol-binding protein-like protein 3 isoform d
[Homo sapiens]
Length = 820
Score = 782 bits (2020), Expect = 0.0
Identities = 421/862 (48%), Positives = 538/862 (62%), Gaps = 89/862 (10%)
Query: 12 PESAQSSKPSSAQQASELWEVVEEPRVRLGTEGVM-----PERQEGHLLKKRKWPLKGWH 66
P + SS S + WEVVE G G M P Q+G LLKKRKWPLKGWH
Sbjct: 17 PSRSTSSCSSKQGSRQDSWEVVE------GLRGEMNYTQEPPVQKGFLLKKRKWPLKGWH 70
Query: 67 KRYFVLEDGILHYATTRQDITKGKLHGSIDVRLSVMSINKKAQRIDLDTEDNIYHLKIKS 126
KR+F L+ GIL YA ++ DI + KLHG IDV LSVMS+ K ++ IDLDTE++IYHLK+KS
Sbjct: 71 KRFFYLDKGILKYAKSQTDIEREKLHGCIDVGLSVMSVKKSSKCIDLDTEEHIYHLKVKS 130
Query: 127 QDLFQSWVAQLRAHRLAHR-------------------LDMPRGSLPSTAHRKVPGAQ-- 165
+++F WV++LR HR+ + D G S + RK
Sbjct: 131 EEVFDEWVSKLRHHRMYRQNEIAMFPHEVNHFFSGSTITDSSSGVFDSISSRKRSSISKQ 190
Query: 166 --LPTAATASALPGLGPREKVSSWLRDSDGLDRCSHELSECQGKLQELHRLLQSLESLHR 223
T + S G +V WL+ S+ +++CS +L+ C L E+ +LLQS++ LHR
Sbjct: 191 NLFQTGSNVSF--SCGGETRVPLWLQSSEDMEKCSKDLAHCHAYLVEMSQLLQSMDVLHR 248
Query: 224 IPSAPVIPTHQASVTTERPKKGKRTSRMWCTQSFAKDDTIGRVGRLHGSVPNLSRYLESR 283
SAP I Q P RLH S PNLS
Sbjct: 249 TYSAPAINAIQVPKPFSGPV------------------------RLHSSNPNLSTLDFGE 284
Query: 284 DSSGTRGLPPT-DYAHLQRSFWALAQKVHSSLSSVLAALTMERDQLRDMHQGSELSRMGV 342
+ + + G + +++ +Q +A KV+ +L S ++ ER++L+
Sbjct: 285 EKNYSDGSETSSEFSKMQEDLCHIAHKVYFTLRSAFNIMSAEREKLK------------- 331
Query: 343 SEASTGQRRLHSLSTSSDTTADSFSSLNPEEQEALYMKGRELTPQLSQTSILSLADSHTE 402
+L SS +A N E + R L QLS S LS+ DS +E
Sbjct: 332 --------QLMEQDASSSPSAQVIGLKNALSSENSRDENRALVHQLSNESRLSITDSLSE 383
Query: 403 FFDACEVLLSASSSENEGSEEEESCTSEITTSLSEEML--DLRGAERCQKGGCVPGRPMG 460
FFDA EVLLS SSSENE S+++ S S+I+ +LS + L DL + GR
Sbjct: 384 FFDAQEVLLSPSSSENEISDDD-SYVSDISDNLSLDNLSNDLDNERQTLGPVLDSGREAK 442
Query: 461 PPRRRCLPAASGPGADVSLWNILRNNIGKDLSKVSMPVQLNEPLNTLQRLCEELEYSSLL 520
RR CLPA +++SLWNILRNNIGKDLSKV+MPV+LNEPLNTLQRLCEELEYS LL
Sbjct: 443 SRRRTCLPAPCPSSSNISLWNILRNNIGKDLSKVAMPVELNEPLNTLQRLCEELEYSELL 502
Query: 521 DQASRIADPCERMVYIAAFAVSAYSSTYHRAGCKPFNPVLGETYECERPDRGFRFISEQV 580
D+A++I P ERMVY+AAFA+SAY+S+Y+RAG KPFNPVLGETYEC R D+GF+F SEQV
Sbjct: 503 DKAAQIPSPLERMVYVAAFAISAYASSYYRAGSKPFNPVLGETYECIREDKGFQFFSEQV 562
Query: 581 SHHPPISACHAESENFAFWQDMKWKNKFWGKSLEIVPVGTVNVSLPRFGDHFEWNKVTSC 640
SHHPPISACHAES NF FWQD++WKNKFWGKS+EIVP+GT +V+LP FGDHFEWNKVTSC
Sbjct: 563 SHHPPISACHAESRNFVFWQDVRWKNKFWGKSMEIVPIGTTHVTLPVFGDHFEWNKVTSC 622
Query: 641 IHNVLSGQRWIEHYGEVLIRNTQDSSCHCKITFCKAKYWSSNVHEVQGAVLSRSGRVLHR 700
IHN+LSGQRWIEHYGE++I+N D SC+CK+ F KAKYWS+N HE++G V RSG+ +HR
Sbjct: 623 IHNILSGQRWIEHYGEIVIKNLHDDSCYCKVNFIKAKYWSTNAHEIEGTVFDRSGKAVHR 682
Query: 701 LFGKWHEGLYRGPTPGGQCIWKPNSMPPDHERNFGFTQFALELNELTAELKRSLPSTDTR 760
LFGKWHE +Y G C+W+ N MP +E+ + FTQFALELNE+ K LP TDTR
Sbjct: 683 LFGKWHESIYCGGGSSSACVWRANPMPKGYEQYYSFTQFALELNEMDPSSKSLLPPTDTR 742
Query: 761 LRPDQRYLEEGNIQAAEAQKRRIEQLQRDRRKVMEENNIVHQARFFRRQTDSSGKEWWVT 820
RPDQR+LEEGN++ AE QK+RIEQLQR+RR+V+EEN++ HQ RFFR+ D S WV+
Sbjct: 743 FRPDQRFLEEGNLEEAEIQKQRIEQLQRERRRVLEENHVEHQPRFFRKSDDDS----WVS 798
Query: 821 NNTYWRLRAEPGYGNMDGAVLW 842
N TY LR + G+ +D VLW
Sbjct: 799 NGTYLELRKDLGFSKLDHPVLW 820
>gi|19718741 oxysterol-binding protein-like 1A isoform B [Homo
sapiens]
Length = 950
Score = 286 bits (732), Expect = 6e-77
Identities = 180/503 (35%), Positives = 255/503 (50%), Gaps = 57/503 (11%)
Query: 372 EEQEALYMKGRELTPQLSQTSILSLADSHTEFFDACEVLLSASSSENEGSEEEESCTSEI 431
E E L + EL L + S + S EF+DA S SE+E S +
Sbjct: 445 EALETLATEHHELEQSLVKGSPPASILSEDEFYDAL------SDSESERSLSRLEAVTAR 498
Query: 432 TTSLSEEMLDLRGAERCQKGGCVPGRPMG---PPRRRCLPAASGPGADVSLWNILRNNIG 488
+ E L R ++ C G + R LP+ D S+W+ILR IG
Sbjct: 499 SFEEEGEHLGSRKHRMSEEKDCGGGDALSNGIKKHRTSLPSPMFSRNDFSIWSILRKCIG 558
Query: 489 KDLSKVSMPVQLNEPLNTLQRLCEELEYSSLLDQASRIADPCERMVYIAAFAVSAYSSTY 548
+LSK++MPV NEPL+ LQRL E +E++ L+ +AS ++DP ERM +AAFAVSA +S +
Sbjct: 559 MELSKITMPVIFNEPLSFLQRLTEYMEHTYLIHKASSLSDPVERMQCVAAFAVSAVASQW 618
Query: 549 HRAGCKPFNPVLGETYECERPDRGFRFISEQVSHHPPISACHAESEN--FAFWQDMKWKN 606
R G KPFNP+LGETYE R D GFR ISEQVSHHPPISA HAE N F F + K
Sbjct: 619 ERTG-KPFNPLLGETYELVRDDLGFRLISEQVSHHPPISAFHAEGLNNDFIFHGSIYPKL 677
Query: 607 KFWGKSLEIVPVGTVNVSLPRFGDHFEWNKVTSCIHNVLSGQRWIEHYGEVLIRNTQDSS 666
KFWGKS+E P GT+ + L + + W T C+HN++ G+ WIE YG V I N +
Sbjct: 678 KFWGKSVEAEPKGTITLELLEHNEAYTWTNPTCCVHNIIVGKLWIEQYGNVEIINHKTGD 737
Query: 667 CHCKITFCKAKYWSSNVHEVQGAVLSRSGRVLHRLFGKWHEGLYRGP------------- 713
C + F + +H+V+G + +S + L L+GKW E LY
Sbjct: 738 -KCVLNFKPCGLFGKELHKVEGYIQDKSKKKLCALYGKWTECLYSVDPATFDAYKKNDKK 796
Query: 714 ------------------------------TPGGQCIWKPNSMPPDHERNFGFTQFALEL 743
PG +W+ PP+ + + FT FA+ L
Sbjct: 797 NTEEKKNSKQMSTSEELDEMPVPDSESVFIIPGSVLLWRIAPRPPNSAQMYNFTSFAMVL 856
Query: 744 NELTAELKRSLPSTDTRLRPDQRYLEEGNIQAAEAQKRRIEQLQRDRRKVMEENNIVHQA 803
NE+ +++ +P TD RLRPD R +E G I A +K+R+E+ QR RK ++ +
Sbjct: 857 NEVDKDMESVIPKTDCRLRPDIRAMENGEIDQASEEKKRLEEKQRAARKNRSKSEEDWKT 916
Query: 804 RFFRRQTDS-SGKEWWVTNNTYW 825
R+F + + +G + W+ + +YW
Sbjct: 917 RWFHQGPNPYNGAQDWIYSGSYW 939
>gi|19718746 oxysterol-binding protein-like 1A isoform A [Homo
sapiens]
Length = 437
Score = 279 bits (714), Expect = 7e-75
Identities = 158/408 (38%), Positives = 223/408 (54%), Gaps = 48/408 (11%)
Query: 464 RRCLPAASGPGADVSLWNILRNNIGKDLSKVSMPVQLNEPLNTLQRLCEELEYSSLLDQA 523
R LP+ D S+W+ILR IG +LSK++MPV NEPL+ LQRL E +E++ L+ +A
Sbjct: 21 RTSLPSPMFSRNDFSIWSILRKCIGMELSKITMPVIFNEPLSFLQRLTEYMEHTYLIHKA 80
Query: 524 SRIADPCERMVYIAAFAVSAYSSTYHRAGCKPFNPVLGETYECERPDRGFRFISEQVSHH 583
S ++DP ERM +AAFAVSA +S + R G KPFNP+LGETYE R D GFR ISEQVSHH
Sbjct: 81 SSLSDPVERMQCVAAFAVSAVASQWERTG-KPFNPLLGETYELVRDDLGFRLISEQVSHH 139
Query: 584 PPISACHAESEN--FAFWQDMKWKNKFWGKSLEIVPVGTVNVSLPRFGDHFEWNKVTSCI 641
PPISA HAE N F F + K KFWGKS+E P GT+ + L + + W T C+
Sbjct: 140 PPISAFHAEGLNNDFIFHGSIYPKLKFWGKSVEAEPKGTITLELLEHNEAYTWTNPTCCV 199
Query: 642 HNVLSGQRWIEHYGEVLIRNTQDSSCHCKITFCKAKYWSSNVHEVQGAVLSRSGRVLHRL 701
HN++ G+ WIE YG V I N + C + F + +H+V+G + +S + L L
Sbjct: 200 HNIIVGKLWIEQYGNVEIINHKTGD-KCVLNFKPCGLFGKELHKVEGYIQDKSKKKLCAL 258
Query: 702 FGKWHEGLYRGP-------------------------------------------TPGGQ 718
+GKW E LY PG
Sbjct: 259 YGKWTECLYSVDPATFDAYKKNDKKNTEEKKNSKQMSTSEELDEMPVPDSESVFIIPGSV 318
Query: 719 CIWKPNSMPPDHERNFGFTQFALELNELTAELKRSLPSTDTRLRPDQRYLEEGNIQAAEA 778
+W+ PP+ + + FT FA+ LNE+ +++ +P TD RLRPD R +E G I A
Sbjct: 319 LLWRIAPRPPNSAQMYNFTSFAMVLNEVDKDMESVIPKTDCRLRPDIRAMENGEIDQASE 378
Query: 779 QKRRIEQLQRDRRKVMEENNIVHQARFFRRQTDS-SGKEWWVTNNTYW 825
+K+R+E+ QR RK ++ + R+F + + +G + W+ + +YW
Sbjct: 379 EKKRLEEKQRAARKNRSKSEEDWKTRWFHQGPNPYNGAQDWIYSGSYW 426
>gi|21450853 oxysterol-binding protein-like protein 2 isoform 2
[Homo sapiens]
Length = 480
Score = 278 bits (712), Expect = 1e-74
Identities = 172/454 (37%), Positives = 240/454 (52%), Gaps = 59/454 (12%)
Query: 402 EFFDACEVLLSASSSENEGSEEEESCTSEITTSLSEEMLDLRGAERCQKGGCVPGRPMGP 461
EFFDA S +SS E SE + T I LD R K G P + G
Sbjct: 6 EFFDAVTGFDSDNSS-GEFSEANQKVTGMID-------LDTSKNNRIGKTGERPSQENGI 57
Query: 462 PRRRC-LPAASGPGADVSLWNILRNNIGKDLSKVSMPVQLNEPLNTLQRLCEELEYSSLL 520
+ R LPA +D S+W IL+ +G +LSK++MP+ NEPL+ LQR+ E +E+ L+
Sbjct: 58 QKHRTSLPAPMFSRSDFSVWTILKKCVGLELSKITMPIAFNEPLSFLQRITEYMEHVYLI 117
Query: 521 DQASRIADPCERMVYIAAFAVSAYSSTYHRAGCKPFNPVLGETYECERPDRGFRFISEQV 580
+AS P ERM +AAFAVSA +S + R G KPFNP+LGETYE R D GFRFISEQV
Sbjct: 118 HRASCQPQPLERMQSVAAFAVSAVASQWERTG-KPFNPLLGETYELIREDLGFRFISEQV 176
Query: 581 SHHPPISACHAESEN--FAFWQDMKWKNKFWGKSLEIVPVGTVNVSLPRFGDHFEWNKVT 638
SHHPPISA H+E N F F + K KFWGKS+E P GT+ + L + + + W T
Sbjct: 177 SHHPPISAFHSEGLNHDFLFHGSIYPKLKFWGKSVEAEPRGTITLELLKHNEAYTWTNPT 236
Query: 639 SCIHNVLSGQRWIEHYGEVLIRNTQDSSCHCKITFCKAKYWSSNVHEVQGAVLSRSGRVL 698
C+HNV+ G+ WIE YG V I N + + C + F + +H+V+G + ++ + L
Sbjct: 237 CCVHNVIIGKLWIEQYGTVEILNHR-TGHKCVLHFKPCGLFGKELHKVEGHIQDKNKKKL 295
Query: 699 HRLFGKWHEGLY---------------RGP------------------------------ 713
++GKW E L+ RG
Sbjct: 296 FMIYGKWTECLWGIDPVSYESFKKQERRGDHLRKAKLDEDSGKADSDVADDVPVAQETVQ 355
Query: 714 -TPGGQCIWKPNSMPPDHERNFGFTQFALELNELTAELKRSLPSTDTRLRPDQRYLEEGN 772
PG + +W+ N+ PP+ + + FT F + LNEL ++++LP TD RLRPD R +E GN
Sbjct: 356 VIPGSKLLWRINTRPPNSAQMYNFTSFTVSLNELETGMEKTLPPTDCRLRPDIRGMENGN 415
Query: 773 IQAAEAQKRRIEQLQRDRRKVMEENNIVHQARFF 806
+ A +K R+E+ QR+ R+ + Q R+F
Sbjct: 416 MDLASQEKERLEEKQREARRERAKEEAEWQTRWF 449
>gi|7662298 oxysterol-binding protein-like protein 2 isoform 1 [Homo
sapiens]
Length = 468
Score = 273 bits (697), Expect = 6e-73
Identities = 163/437 (37%), Positives = 233/437 (53%), Gaps = 52/437 (11%)
Query: 420 GSEEEESCTSEITTSLSEEM-LDLRGAERCQKGGCVPGRPMGPPRRRC-LPAASGPGADV 477
G EE +E ++ + LD R K G P + G + R LPA +D
Sbjct: 3 GEEEFFDAVTEANQKVTGMIDLDTSKNNRIGKTGERPSQENGIQKHRTSLPAPMFSRSDF 62
Query: 478 SLWNILRNNIGKDLSKVSMPVQLNEPLNTLQRLCEELEYSSLLDQASRIADPCERMVYIA 537
S+W IL+ +G +LSK++MP+ NEPL+ LQR+ E +E+ L+ +AS P ERM +A
Sbjct: 63 SVWTILKKCVGLELSKITMPIAFNEPLSFLQRITEYMEHVYLIHRASCQPQPLERMQSVA 122
Query: 538 AFAVSAYSSTYHRAGCKPFNPVLGETYECERPDRGFRFISEQVSHHPPISACHAESEN-- 595
AFAVSA +S + R G KPFNP+LGETYE R D GFRFISEQVSHHPPISA H+E N
Sbjct: 123 AFAVSAVASQWERTG-KPFNPLLGETYELIREDLGFRFISEQVSHHPPISAFHSEGLNHD 181
Query: 596 FAFWQDMKWKNKFWGKSLEIVPVGTVNVSLPRFGDHFEWNKVTSCIHNVLSGQRWIEHYG 655
F F + K KFWGKS+E P GT+ + L + + + W T C+HNV+ G+ WIE YG
Sbjct: 182 FLFHGSIYPKLKFWGKSVEAEPRGTITLELLKHNEAYTWTNPTCCVHNVIIGKLWIEQYG 241
Query: 656 EVLIRNTQDSSCHCKITFCKAKYWSSNVHEVQGAVLSRSGRVLHRLFGKWHEGLY----- 710
V I N + + C + F + +H+V+G + ++ + L ++GKW E L+
Sbjct: 242 TVEILNHR-TGHKCVLHFKPCGLFGKELHKVEGHIQDKNKKKLFMIYGKWTECLWGIDPV 300
Query: 711 ----------RGP-------------------------------TPGGQCIWKPNSMPPD 729
RG PG + +W+ N+ PP+
Sbjct: 301 SYESFKKQERRGDHLRKAKLDEDSGKADSDVADDVPVAQETVQVIPGSKLLWRINTRPPN 360
Query: 730 HERNFGFTQFALELNELTAELKRSLPSTDTRLRPDQRYLEEGNIQAAEAQKRRIEQLQRD 789
+ + FT F + LNEL ++++LP TD RLRPD R +E GN+ A +K R+E+ QR+
Sbjct: 361 SAQMYNFTSFTVSLNELETGMEKTLPPTDCRLRPDIRGMENGNMDLASQEKERLEEKQRE 420
Query: 790 RRKVMEENNIVHQARFF 806
R+ + Q R+F
Sbjct: 421 ARRERAKEEAEWQTRWF 437
>gi|4505531 oxysterol binding protein [Homo sapiens]
Length = 807
Score = 257 bits (657), Expect = 3e-68
Identities = 168/475 (35%), Positives = 252/475 (53%), Gaps = 55/475 (11%)
Query: 394 LSLADSHTEFFDACEVLLSASSSENEGSEEEESCTSEITTSLSEEMLDLRGAERCQKGGC 453
+S D EFFDA E++ + EN G + S S ++ +S + E +K
Sbjct: 350 MSDEDDENEFFDAPEII---TMPENLGHKRTGSNISGASSDISLDEQYKHQLEETKK--- 403
Query: 454 VPGRPMGPPRRRCLPAASGPGADVSLWNILRNNIGKDLSKVSMPVQLNEPLNTLQRLCEE 513
+R +P P ++LW+I++N IGK+LSK+ MPV NEPL+ LQRL E+
Sbjct: 404 --------EKRTRIPYK--PNYSLNLWSIMKNCIGKELSKIPMPVNFNEPLSMLQRLTED 453
Query: 514 LEYSSLLDQASRIADPCERMVYIAAFAVSAYSSTYHRAGCKPFNPVLGETYECER-PDRG 572
LEY LLD+A++ + E++ Y+AAF VS+YS+T R KPFNP+LGET+E +R + G
Sbjct: 454 LEYHELLDRAAKCENSLEQLCYVAAFTVSSYSTTVFRTS-KPFNPLLGETFELDRLEENG 512
Query: 573 FRFISEQVSHHPPISACHAESEN-FAFWQDMKWKNKFWGKSLEIVPVGTVNVSLPRFGDH 631
+R + EQVSHHPP +A HAES+N + Q++K +KF GK L I+P+GT++ G H
Sbjct: 513 YRSLCEQVSHHPPAAAHHAESKNGWTLRQEIKITSKFRGKYLSIMPLGTIHCIFHATGHH 572
Query: 632 FEWNKVTSCIHNVLSGQRWIEHYGEVLIRNTQDSSCHCKITFCKAKYWSSNV-HEVQGAV 690
+ W KVT+ +HN++ G+ WI+ GE+ I N + C + F Y+S +V +V G V
Sbjct: 573 YTWKKVTTTVHNIIVGKLWIDQSGEIDIVNHKTGD-KCNLKFVPYSYFSRDVARKVTGEV 631
Query: 691 LSRSGRVLHRLFGKWHEGL-----------------YRG--PTPGGQCIWKPNSMPPDHE 731
SG+V L G W E + RG +WK N +P + E
Sbjct: 632 TDPSGKVHFALLGTWDEKMECFKVQPVIGENGGDARQRGHEAEESRVMLWKRNPLPKNAE 691
Query: 732 RNFGFTQFALELNELTAELKRSLPSTDTRLRPDQRYLEEGNIQAAEAQKRRIEQLQRDRR 791
+ F++ AL LN + TD+RLRPDQR +E G A A+K+R+E+ QR R
Sbjct: 692 NMYYFSELALTLN----AWESGTAPTDSRLRPDQRLMENGRWDEANAEKQRLEEKQRLSR 747
Query: 792 KVMEENNI----------VHQARFFRRQTDSSGKE-WWVTNNTYWRLRAEPGYGN 835
K E + ++A +F R+ D KE + YW + + + +
Sbjct: 748 KKREAEAMKATEDGTPYDPYKALWFERKKDPVTKELTHIYRGEYWECKEKQDWSS 802
Score = 41.2 bits (95), Expect = 0.004
Identities = 25/88 (28%), Positives = 47/88 (53%), Gaps = 2/88 (2%)
Query: 50 QEGHLLKKRKWPLKGWHKRYFVLEDGILHYATTRQDITKGKLHGSIDVRLSVMSINKKAQ 109
+EG L K + +KG+ +R+FVL +G+L Y ++ ++ + G+I++ + +++
Sbjct: 91 REGWLFKWTNY-IKGYQRRWFVLSNGLLSYYRSKAEM-RHTCRGTINLATANITVEDSCN 148
Query: 110 RIDLDTEDNIYHLKIKSQDLFQSWVAQL 137
I + YHLK S+ Q WV L
Sbjct: 149 FIISNGGAQTYHLKASSEVERQRWVTAL 176
>gi|13540513 oxysterol binding protein 2 isoform a [Homo sapiens]
Length = 916
Score = 253 bits (646), Expect = 5e-67
Identities = 156/454 (34%), Positives = 246/454 (54%), Gaps = 49/454 (10%)
Query: 371 PEEQEALYMKGRELTPQLSQTSILSLADSHTEFFDACE-----VLLSASSSENEGSEEEE 425
P +++G LTP+ + D TE+FDA E + + + E+ E
Sbjct: 424 PANPSKSFIEGSLLTPKGEDSE----EDEDTEYFDAMEDSTSFITVITEAKEDSRKAEGS 479
Query: 426 SCTSEITTSLSEEMLDLRGAERCQKGGCVPGRPMGPPRRRCLPAASGPGADVSLWNILRN 485
+ TS + S ++ +LD GA KG R + P + P ++LW+I++N
Sbjct: 480 TGTSSVDWSSADNVLD--GASLVPKGSSKVKRRVRIPNK--------PNYSLNLWSIMKN 529
Query: 486 NIGKDLSKVSMPVQLNEPLNTLQRLCEELEYSSLLDQASRIADPCERMVYIAAFAVSAYS 545
IG++LS++ MPV NEPL+ LQRL E+LEY LLD+A E+M +AAF+VS+YS
Sbjct: 530 CIGRELSRIPMPVNFNEPLSMLQRLTEDLEYHHLLDKAVHCTSSVEQMCLVAAFSVSSYS 589
Query: 546 STYHRAGCKPFNPVLGETYECER-PDRGFRFISEQVSHHPPISACHAESEN-FAFWQDMK 603
+T HR KPFNP+LGET+E +R D G R + EQVSHHPP +A + S++ ++ WQ++
Sbjct: 590 TTVHRI-AKPFNPMLGETFELDRLDDMGLRSLCEQVSHHPPSAAHYVFSKHGWSLWQEIT 648
Query: 604 WKNKFWGKSLEIVPVGTVNVSLPRFGDHFEWNKVTSCIHNVLSGQRWIEHYGEVLIRNTQ 663
+KF GK + I+P+G +++ G+H+ W K TS +HN++ G+ WI+ G++ I N +
Sbjct: 649 ISSKFRGKYISIMPLGAIHLEFQASGNHYVWRKSTSTVHNIIVGKLWIDQSGDIEIVNHK 708
Query: 664 DSSCHCKITFCKAKYWSSN-VHEVQGAVLSRSGRVLHRLFGKWHEG------LYRGP--- 713
+ C++ F Y+S +V G V G+ + L G W E ++ P
Sbjct: 709 TND-RCQLKFLPYSYFSKEAARKVTGVVSDSQGKAHYVLSGSWDEQMECSKVMHSSPSSP 767
Query: 714 -----------TPGGQCIWKPNSMPPDHERNFGFTQFALELNELTAELKRSLPSTDTRLR 762
T + +WK +P + E + F++ AL LN E + + TD+RLR
Sbjct: 768 SSDGKQKTVYQTLSAKLLWKKYPLPENAENMYYFSELALTLN----EHEEGVAPTDSRLR 823
Query: 763 PDQRYLEEGNIQAAEAQKRRIEQLQR-DRRKVME 795
PDQR +E+G A +K+R+E+ QR RR+ +E
Sbjct: 824 PDQRLMEKGRWDEANTEKQRLEEKQRLSRRRRLE 857
Score = 36.2 bits (82), Expect = 0.13
Identities = 27/87 (31%), Positives = 46/87 (52%), Gaps = 3/87 (3%)
Query: 51 EGHLLKKRKWPLKGWHKRYFVLEDGILHYATTRQDITKGKLHGSIDVRLSVMSINKKAQR 110
EG LLK + LKG+ +R+FVL +G+L Y + ++ G+I++ + + + +
Sbjct: 186 EGWLLKWTNY-LKGYQRRWFVLGNGLLSYYRNQGEMAH-TCRGTINLSTAHID-TEDSCG 242
Query: 111 IDLDTEDNIYHLKIKSQDLFQSWVAQL 137
I L + YHLK S+ Q W+ L
Sbjct: 243 ILLTSGARSYHLKASSEVDRQQWITAL 269
>gi|14149740 oxysterol-binding protein-like protein 5 isoform a
[Homo sapiens]
Length = 879
Score = 95.9 bits (237), Expect = 1e-19
Identities = 86/350 (24%), Positives = 157/350 (44%), Gaps = 26/350 (7%)
Query: 479 LWNILRN-NIGKDLSKVSMPVQLNEPLNTLQRLCEELEYSSLLDQASRIADPCERMVYIA 537
+W +L+ G DLS+V +P + EP + L +L + ++ LL +A+ D RM +
Sbjct: 371 MWTLLKQLRPGMDLSRVVLPTFVLEPRSFLNKLSDYYYHADLLSRAAVEEDAYSRMKLVL 430
Query: 538 AFAVSAYSSTYHRAGCKPFNPVLGETYEC----ERPDRGFRFISEQVSHHPPISACHAES 593
+ +S + + KP+NP+LGET+ C + D +I+EQVSHHPP+SA H +
Sbjct: 431 RWYLSGFYKK-PKGIKKPYNPILGETFRCCWFHPQTDSRTFYIAEQVSHHPPVSAFHVSN 489
Query: 594 --ENFAFWQDMKWKNKFWGKSLEIVPVGTVNVSLPRFGDHFEWNKVTSCIHNVLSGQRWI 651
+ F + K++F+G SL + G ++ + + + +L G +
Sbjct: 490 RKDGFCISGSITAKSRFYGNSLSALLDGKATLTFLNRAEDYTLTMPYAHCKGILYGTMTL 549
Query: 652 EHYGEVLIRNTQDSSCHCKITFCKAKYW--SSNVHEVQGAVLSRSGRVLHRLFGKWHEGL 709
E G+V I + ++ ++ F ++ S++++++ G + S VL L G W +
Sbjct: 550 ELGGKVTIECAK-NNFQAQLEFKLKPFFGGSTSINQISGKITS-GEEVLASLSGHWDRDV 607
Query: 710 YRGPTPGGQ--CIWKPNSMPPDHERNFGFTQFALELNELTAELKRSLPSTDTRLRPDQRY 767
+ G W P+ R Q + L E T L TR
Sbjct: 608 FIKEEGSGSSALFWTPSG----EVRRQRLRQHTVPLEEQTELESERLWQHVTRA------ 657
Query: 768 LEEGNIQAAEAQKRRIEQLQRDRRKVMEENNIVHQARFFRRQTDSSGKEW 817
+ +G+ A +K +E+ QR R + +E+ + + + F D +EW
Sbjct: 658 ISKGDQHRATQEKFALEEAQRQRARERQESLMPWKPQLF--HLDPITQEW 705
>gi|221136766 oxysterol-binding protein-like protein 5 isoform b
[Homo sapiens]
Length = 811
Score = 95.9 bits (237), Expect = 1e-19
Identities = 86/350 (24%), Positives = 157/350 (44%), Gaps = 26/350 (7%)
Query: 479 LWNILRN-NIGKDLSKVSMPVQLNEPLNTLQRLCEELEYSSLLDQASRIADPCERMVYIA 537
+W +L+ G DLS+V +P + EP + L +L + ++ LL +A+ D RM +
Sbjct: 303 MWTLLKQLRPGMDLSRVVLPTFVLEPRSFLNKLSDYYYHADLLSRAAVEEDAYSRMKLVL 362
Query: 538 AFAVSAYSSTYHRAGCKPFNPVLGETYEC----ERPDRGFRFISEQVSHHPPISACHAES 593
+ +S + + KP+NP+LGET+ C + D +I+EQVSHHPP+SA H +
Sbjct: 363 RWYLSGFYKK-PKGIKKPYNPILGETFRCCWFHPQTDSRTFYIAEQVSHHPPVSAFHVSN 421
Query: 594 --ENFAFWQDMKWKNKFWGKSLEIVPVGTVNVSLPRFGDHFEWNKVTSCIHNVLSGQRWI 651
+ F + K++F+G SL + G ++ + + + +L G +
Sbjct: 422 RKDGFCISGSITAKSRFYGNSLSALLDGKATLTFLNRAEDYTLTMPYAHCKGILYGTMTL 481
Query: 652 EHYGEVLIRNTQDSSCHCKITFCKAKYW--SSNVHEVQGAVLSRSGRVLHRLFGKWHEGL 709
E G+V I + ++ ++ F ++ S++++++ G + S VL L G W +
Sbjct: 482 ELGGKVTIECAK-NNFQAQLEFKLKPFFGGSTSINQISGKITS-GEEVLASLSGHWDRDV 539
Query: 710 YRGPTPGGQ--CIWKPNSMPPDHERNFGFTQFALELNELTAELKRSLPSTDTRLRPDQRY 767
+ G W P+ R Q + L E T L TR
Sbjct: 540 FIKEEGSGSSALFWTPSG----EVRRQRLRQHTVPLEEQTELESERLWQHVTRA------ 589
Query: 768 LEEGNIQAAEAQKRRIEQLQRDRRKVMEENNIVHQARFFRRQTDSSGKEW 817
+ +G+ A +K +E+ QR R + +E+ + + + F D +EW
Sbjct: 590 ISKGDQHRATQEKFALEEAQRQRARERQESLMPWKPQLF--HLDPITQEW 637
>gi|22035609 oxysterol-binding protein-like protein 5 isoform b
[Homo sapiens]
Length = 811
Score = 95.9 bits (237), Expect = 1e-19
Identities = 86/350 (24%), Positives = 157/350 (44%), Gaps = 26/350 (7%)
Query: 479 LWNILRN-NIGKDLSKVSMPVQLNEPLNTLQRLCEELEYSSLLDQASRIADPCERMVYIA 537
+W +L+ G DLS+V +P + EP + L +L + ++ LL +A+ D RM +
Sbjct: 303 MWTLLKQLRPGMDLSRVVLPTFVLEPRSFLNKLSDYYYHADLLSRAAVEEDAYSRMKLVL 362
Query: 538 AFAVSAYSSTYHRAGCKPFNPVLGETYEC----ERPDRGFRFISEQVSHHPPISACHAES 593
+ +S + + KP+NP+LGET+ C + D +I+EQVSHHPP+SA H +
Sbjct: 363 RWYLSGFYKK-PKGIKKPYNPILGETFRCCWFHPQTDSRTFYIAEQVSHHPPVSAFHVSN 421
Query: 594 --ENFAFWQDMKWKNKFWGKSLEIVPVGTVNVSLPRFGDHFEWNKVTSCIHNVLSGQRWI 651
+ F + K++F+G SL + G ++ + + + +L G +
Sbjct: 422 RKDGFCISGSITAKSRFYGNSLSALLDGKATLTFLNRAEDYTLTMPYAHCKGILYGTMTL 481
Query: 652 EHYGEVLIRNTQDSSCHCKITFCKAKYW--SSNVHEVQGAVLSRSGRVLHRLFGKWHEGL 709
E G+V I + ++ ++ F ++ S++++++ G + S VL L G W +
Sbjct: 482 ELGGKVTIECAK-NNFQAQLEFKLKPFFGGSTSINQISGKITS-GEEVLASLSGHWDRDV 539
Query: 710 YRGPTPGGQ--CIWKPNSMPPDHERNFGFTQFALELNELTAELKRSLPSTDTRLRPDQRY 767
+ G W P+ R Q + L E T L TR
Sbjct: 540 FIKEEGSGSSALFWTPSG----EVRRQRLRQHTVPLEEQTELESERLWQHVTRA------ 589
Query: 768 LEEGNIQAAEAQKRRIEQLQRDRRKVMEENNIVHQARFFRRQTDSSGKEW 817
+ +G+ A +K +E+ QR R + +E+ + + + F D +EW
Sbjct: 590 ISKGDQHRATQEKFALEEAQRQRARERQESLMPWKPQLF--HLDPITQEW 637
>gi|19923812 oxysterol-binding protein-like protein 10 [Homo
sapiens]
Length = 764
Score = 95.5 bits (236), Expect = 2e-19
Identities = 88/375 (23%), Positives = 158/375 (42%), Gaps = 56/375 (14%)
Query: 487 IGKDLSKVSMPVQLNEPLNTLQRLCEELEYSSLLDQASRIADPCERMVYIAAFAVSAYSS 546
+G DL+KV +P + E + L+ + + + LL + A P ER++ + ++A+
Sbjct: 409 LGMDLTKVVLPTFILEKRSLLEMYADFMAHPDLLLAITAGATPEERVICFVEYYLTAFHE 468
Query: 547 TYHRA-GCKPFNPVLGETYEC----------------------------ERPDRGF--RF 575
A KP+NP++GET+ C + P + + RF
Sbjct: 469 GRKGALAKKPYNPIIGETFHCSWEVPKDRVKPKRTASRSPASCHEHPMADDPSKSYKLRF 528
Query: 576 ISEQVSHHPPISA--CHAESENFAFWQDMKWKNKFWGKSLEIVPVGTVNVSLPRFGDHFE 633
++EQVSHHPPIS C E + + K+KF G S+ + +G + L G+ +
Sbjct: 529 VAEQVSHHPPISCFYCECEEKRLCVNTHVWTKSKFMGMSVGVSMIGEGVLRLLEHGEEYV 588
Query: 634 WNKVTSCIHNVLSGQRWIEHYGEVLIRNTQDSSCHCKITFCKAKYWSSNVHEVQGAVL-S 692
+ ++ ++L+ W+E G+V I N + + F ++ VH V V +
Sbjct: 589 FTLPSAYARSILT-IPWVELGGKVSI-NCAKTGYSATVIFHTKPFYGGKVHRVTAEVKHN 646
Query: 693 RSGRVLHRLFGKWHEGLYRGPTPGGQCIWKPNSMPPDHERNFGFTQFALELNELTAELKR 752
+ ++ + G+W+ L G + ++P ++ L++
Sbjct: 647 PTNTIVCKAHGEWNGTLEFTYNNGETKVIDTTTLPVYPKK--------------IRPLEK 692
Query: 753 SLPSTDTRL-RPDQRYLEEGNIQAAEAQKRRIEQLQRDRRKVMEENNIVHQARFFRRQTD 811
P L R RYL G+I AA QKR +E+ QR + E + ++F ++ D
Sbjct: 693 QGPMESRNLWREVTRYLRLGDIDAATEQKRHLEEKQRVEERKRENLRTPWKPKYFIQEGD 752
Query: 812 SSGKEWWVTNNTYWR 826
WV N W+
Sbjct: 753 G-----WVYFNPLWK 762
Score = 46.2 bits (108), Expect = 1e-04
Identities = 52/182 (28%), Positives = 79/182 (43%), Gaps = 21/182 (11%)
Query: 62 LKGWHKRYFVL--EDGILHYATTRQDITKGKLHGSIDVRLSVMSINKKAQRIDLDTEDNI 119
L+GW RYFVL E GIL Y Q K G + + +++S++ +A + + N
Sbjct: 88 LQGWQNRYFVLDFEAGILQYFVNEQS-KHQKPRGVLSLSGAIVSLSDEAPHMLVVYSANG 146
Query: 120 YHLKIKSQDL--FQSWVAQLRAHRLAHRLDMPRGSLPSTAHRKVPGAQLPTAATASALP- 176
K+++ D Q WV QLRA H ++M S PS+ R + LP SA P
Sbjct: 147 EMFKLRAADAKEKQFWVTQLRACAKYH-MEMNSKSAPSSRSRSL--TLLPHGTPNSASPC 203
Query: 177 -----GLGPREKVSSWLRDSDGLDRCSHELSECQGKLQELHRLLQSLES-----LHRIPS 226
+G V+ S R S+ G+L E+ ++ +E +H I S
Sbjct: 204 SQRHLSVGAPGVVTITHHKSPAAAR--RAKSQYSGQLHEVREMMNQVEGQQKNLVHAIES 261
Query: 227 AP 228
P
Sbjct: 262 LP 263
>gi|51243032 oxysterol-binding protein-like protein 8 isoform b
[Homo sapiens]
Length = 847
Score = 94.4 bits (233), Expect = 4e-19
Identities = 117/470 (24%), Positives = 190/470 (40%), Gaps = 61/470 (12%)
Query: 353 HSLSTSSDTTADSFSSLNPEEQEALYMKGRELTPQLSQTSILSLADSHTEFFDACEVLLS 412
H LS SSD+T +F L L L DS E + +
Sbjct: 239 HDLSVSSDSTHVTFYGLLRANN-------------LHSGDNFQLNDSEIERQHFKDQDMY 285
Query: 413 ASSSENEGSEEEESCTSEITTSLSEEMLDLRGAERCQKGGCVPGRPMGPPRRRCLPAAS- 471
+ S+ E +E + +E+ E D +ER Q + P+ P + S
Sbjct: 286 SDKSDKENDQEHDESDNEVMGKSEESDTDT--SER-QDDSYIEPEPVEPLKETTYTEQSH 342
Query: 472 ---GPGADVS------------LWNILRN-NIGKDLSKVSMPVQLNEPLNTLQRLCEELE 515
G + S +W +L+ G DLSKV +P + EP + L +L +
Sbjct: 343 EELGEAGEASQTETVSEENKSLIWTLLKQVRPGMDLSKVVLPTFILEPRSFLDKLSDYYY 402
Query: 516 YSSLLDQASRIADPCERMVYIAAFAVSAYSSTYHRAGCKPFNPVLGETYEC----ERPDR 571
++ L +A+ +P R+ + + +S + + KP+NP+LGET+ C R +
Sbjct: 403 HADFLSEAALEENPYFRLKKVVKWYLSGFYKK-PKGLKKPYNPILGETFRCLWIHPRTNS 461
Query: 572 GFRFISEQVSHHPPISACHAES--ENFAFWQDMKWKNKFWGKSLEIVPVGTVNVSLPRFG 629
+I+EQVSHHPPISA + + + F + K+KF+G SL + G ++ G
Sbjct: 462 KTFYIAEQVSHHPPISAFYVSNRKDGFCLSGSILAKSKFYGNSLSAILEGEARLTFLNRG 521
Query: 630 DHFEWNKVTSCIHNVLSGQRWIEHYGEVLIRNTQDSSCHCKITFCKAKYW---SSNVHEV 686
+ + + +L G +E G V I T + + I K K + S V+++
Sbjct: 522 EDYVMTMPYAHCKGILYGTMTLELGGTVNI--TCQKTGYSAILEFKLKPFLGSSDCVNQI 579
Query: 687 QGAVLSRSGRVLHRLFGKWHEGLY--RGPTPGGQCIWKPNSMPPD--------HERNFGF 736
G L VL L G W ++ T + W P PD H F
Sbjct: 580 SGK-LKLGKEVLATLEGHWDSEVFITDKKTDNSEVFWNPT---PDIKQWRLIRHTVKFE- 634
Query: 737 TQFALELNELTAELKRSLPSTDTRLRPDQRY-LEEGNIQAAEAQKRRIEQ 785
Q E +L + R++ + D ++Y LEE QAA +K + E+
Sbjct: 635 EQGDFESEKLWQRVTRAINAKDQTEATQEKYVLEEAQRQAARDRKTKNEE 684
>gi|18079218 oxysterol-binding protein-like protein 8 isoform a
[Homo sapiens]
Length = 889
Score = 94.4 bits (233), Expect = 4e-19
Identities = 117/470 (24%), Positives = 190/470 (40%), Gaps = 61/470 (12%)
Query: 353 HSLSTSSDTTADSFSSLNPEEQEALYMKGRELTPQLSQTSILSLADSHTEFFDACEVLLS 412
H LS SSD+T +F L L L DS E + +
Sbjct: 281 HDLSVSSDSTHVTFYGLLRANN-------------LHSGDNFQLNDSEIERQHFKDQDMY 327
Query: 413 ASSSENEGSEEEESCTSEITTSLSEEMLDLRGAERCQKGGCVPGRPMGPPRRRCLPAAS- 471
+ S+ E +E + +E+ E D +ER Q + P+ P + S
Sbjct: 328 SDKSDKENDQEHDESDNEVMGKSEESDTDT--SER-QDDSYIEPEPVEPLKETTYTEQSH 384
Query: 472 ---GPGADVS------------LWNILRN-NIGKDLSKVSMPVQLNEPLNTLQRLCEELE 515
G + S +W +L+ G DLSKV +P + EP + L +L +
Sbjct: 385 EELGEAGEASQTETVSEENKSLIWTLLKQVRPGMDLSKVVLPTFILEPRSFLDKLSDYYY 444
Query: 516 YSSLLDQASRIADPCERMVYIAAFAVSAYSSTYHRAGCKPFNPVLGETYEC----ERPDR 571
++ L +A+ +P R+ + + +S + + KP+NP+LGET+ C R +
Sbjct: 445 HADFLSEAALEENPYFRLKKVVKWYLSGFYKK-PKGLKKPYNPILGETFRCLWIHPRTNS 503
Query: 572 GFRFISEQVSHHPPISACHAES--ENFAFWQDMKWKNKFWGKSLEIVPVGTVNVSLPRFG 629
+I+EQVSHHPPISA + + + F + K+KF+G SL + G ++ G
Sbjct: 504 KTFYIAEQVSHHPPISAFYVSNRKDGFCLSGSILAKSKFYGNSLSAILEGEARLTFLNRG 563
Query: 630 DHFEWNKVTSCIHNVLSGQRWIEHYGEVLIRNTQDSSCHCKITFCKAKYW---SSNVHEV 686
+ + + +L G +E G V I T + + I K K + S V+++
Sbjct: 564 EDYVMTMPYAHCKGILYGTMTLELGGTVNI--TCQKTGYSAILEFKLKPFLGSSDCVNQI 621
Query: 687 QGAVLSRSGRVLHRLFGKWHEGLY--RGPTPGGQCIWKPNSMPPD--------HERNFGF 736
G L VL L G W ++ T + W P PD H F
Sbjct: 622 SGK-LKLGKEVLATLEGHWDSEVFITDKKTDNSEVFWNPT---PDIKQWRLIRHTVKFE- 676
Query: 737 TQFALELNELTAELKRSLPSTDTRLRPDQRY-LEEGNIQAAEAQKRRIEQ 785
Q E +L + R++ + D ++Y LEE QAA +K + E+
Sbjct: 677 EQGDFESEKLWQRVTRAINAKDQTEATQEKYVLEEAQRQAARDRKTKNEE 726
>gi|20070331 oxysterol binding protein-like 9 isoform e [Homo
sapiens]
Length = 736
Score = 85.9 bits (211), Expect = 1e-16
Identities = 87/347 (25%), Positives = 145/347 (41%), Gaps = 43/347 (12%)
Query: 487 IGKDLSKVSMPVQLNEPLNTLQRLCEELEYSSLLDQASRIADPCERMVYIAAFAVSAYSS 546
+G DL+KV +P + E + L+ + + L S DP +RMV + + +SA+ +
Sbjct: 384 LGMDLTKVVLPTFILERRSLLEMYADFFAHPDLFVSISDQKDPKDRMVQVVKWYLSAFHA 443
Query: 547 TYHRAGC---KPFNPVLGETYEC----------------ERP-----DRGFRFISEQVSH 582
R G KP+NP+LGE ++C E P F++EQVSH
Sbjct: 444 G--RKGSVAKKPYNPILGEIFQCHWTLPNDTEENTELVSEGPVPWVSKNSVTFVAEQVSH 501
Query: 583 HPPISACHAE--SENFAFWQDMKWKNKFWGKSLEIVPVGTVNVSLPRFGDHFEWNKVTSC 640
HPPISA +AE ++ F + K+KF G S+ + +G VS + +H+
Sbjct: 502 HPPISAFYAECFNKKIQFNAHIWTKSKFLGMSIGVHNIGQGCVSCLDYDEHYILTFPNGY 561
Query: 641 IHNVLSGQRWIEHYGEVLIRNTQDSSCHCKITFCKAKYWSSNVHEVQGAVLS-RSGRVLH 699
++L+ W+E GE I N + I F ++ H + + S +
Sbjct: 562 GRSILT-VPWVELGGECNI-NCSKTGYSANIIFHTKPFYGGKKHRITAEIFSPNDKKSFC 619
Query: 700 RLFGKWHEGLYRGPTPGGQCIWKPNSMPPDHERNFGFTQFALELNELTAELKRSLPSTDT 759
+ G+W+ +Y G ++ P ++ +L + RSL T
Sbjct: 620 SIEGEWNGVMYAKYATGENTVFVDTKKLPIIKKK------VRKLEDQNEYESRSLWKDVT 673
Query: 760 RLRPDQRYLEEGNIQAAEAQKRRIEQLQRDRRKVMEENNIVHQARFF 806
L+ +I AA K R+E+ QR + +E I + R F
Sbjct: 674 ------FNLKIRDIDAATEAKHRLEERQRAEARERKEKEIQWETRLF 714
Score = 45.1 bits (105), Expect = 3e-04
Identities = 25/95 (26%), Positives = 47/95 (49%), Gaps = 5/95 (5%)
Query: 59 KWP--LKGWHKRYFVLE--DGILHYATTRQDITKGKLHGSIDVRLSVMSI-NKKAQRIDL 113
KW +KGW R+FVL+ G+L Y T++ + +G G + +R +V+ I ++ +
Sbjct: 11 KWTNVMKGWQYRWFVLDYNAGLLSYYTSKDKMMRGSRRGCVRLRGAVIGIDDEDDSTFTI 70
Query: 114 DTEDNIYHLKIKSQDLFQSWVAQLRAHRLAHRLDM 148
+ +H + + D + W+ L L H L +
Sbjct: 71 TVDQKTFHFQARDADEREKWIHALEETILRHTLQL 105
>gi|22547176 oxysterol binding protein-like 9 isoform f [Homo
sapiens]
Length = 746
Score = 85.9 bits (211), Expect = 1e-16
Identities = 87/347 (25%), Positives = 145/347 (41%), Gaps = 43/347 (12%)
Query: 487 IGKDLSKVSMPVQLNEPLNTLQRLCEELEYSSLLDQASRIADPCERMVYIAAFAVSAYSS 546
+G DL+KV +P + E + L+ + + L S DP +RMV + + +SA+ +
Sbjct: 394 LGMDLTKVVLPTFILERRSLLEMYADFFAHPDLFVSISDQKDPKDRMVQVVKWYLSAFHA 453
Query: 547 TYHRAGC---KPFNPVLGETYEC----------------ERP-----DRGFRFISEQVSH 582
R G KP+NP+LGE ++C E P F++EQVSH
Sbjct: 454 G--RKGSVAKKPYNPILGEIFQCHWTLPNDTEENTELVSEGPVPWVSKNSVTFVAEQVSH 511
Query: 583 HPPISACHAE--SENFAFWQDMKWKNKFWGKSLEIVPVGTVNVSLPRFGDHFEWNKVTSC 640
HPPISA +AE ++ F + K+KF G S+ + +G VS + +H+
Sbjct: 512 HPPISAFYAECFNKKIQFNAHIWTKSKFLGMSIGVHNIGQGCVSCLDYDEHYILTFPNGY 571
Query: 641 IHNVLSGQRWIEHYGEVLIRNTQDSSCHCKITFCKAKYWSSNVHEVQGAVLS-RSGRVLH 699
++L+ W+E GE I N + I F ++ H + + S +
Sbjct: 572 GRSILT-VPWVELGGECNI-NCSKTGYSANIIFHTKPFYGGKKHRITAEIFSPNDKKSFC 629
Query: 700 RLFGKWHEGLYRGPTPGGQCIWKPNSMPPDHERNFGFTQFALELNELTAELKRSLPSTDT 759
+ G+W+ +Y G ++ P ++ +L + RSL T
Sbjct: 630 SIEGEWNGVMYAKYATGENTVFVDTKKLPIIKKK------VRKLEDQNEYESRSLWKDVT 683
Query: 760 RLRPDQRYLEEGNIQAAEAQKRRIEQLQRDRRKVMEENNIVHQARFF 806
L+ +I AA K R+E+ QR + +E I + R F
Sbjct: 684 ------FNLKIRDIDAATEAKHRLEERQRAEARERKEKEIQWETRLF 724
Score = 45.1 bits (105), Expect = 3e-04
Identities = 25/95 (26%), Positives = 47/95 (49%), Gaps = 5/95 (5%)
Query: 59 KWP--LKGWHKRYFVLE--DGILHYATTRQDITKGKLHGSIDVRLSVMSI-NKKAQRIDL 113
KW +KGW R+FVL+ G+L Y T++ + +G G + +R +V+ I ++ +
Sbjct: 11 KWTNVMKGWQYRWFVLDYNAGLLSYYTSKDKMMRGSRRGCVRLRGAVIGIDDEDDSTFTI 70
Query: 114 DTEDNIYHLKIKSQDLFQSWVAQLRAHRLAHRLDM 148
+ +H + + D + W+ L L H L +
Sbjct: 71 TVDQKTFHFQARDADEREKWIHALEETILRHTLQL 105
>gi|22547173 oxysterol binding protein-like 9 isoform d [Homo
sapiens]
Length = 723
Score = 85.9 bits (211), Expect = 1e-16
Identities = 87/347 (25%), Positives = 145/347 (41%), Gaps = 43/347 (12%)
Query: 487 IGKDLSKVSMPVQLNEPLNTLQRLCEELEYSSLLDQASRIADPCERMVYIAAFAVSAYSS 546
+G DL+KV +P + E + L+ + + L S DP +RMV + + +SA+ +
Sbjct: 371 LGMDLTKVVLPTFILERRSLLEMYADFFAHPDLFVSISDQKDPKDRMVQVVKWYLSAFHA 430
Query: 547 TYHRAGC---KPFNPVLGETYEC----------------ERP-----DRGFRFISEQVSH 582
R G KP+NP+LGE ++C E P F++EQVSH
Sbjct: 431 G--RKGSVAKKPYNPILGEIFQCHWTLPNDTEENTELVSEGPVPWVSKNSVTFVAEQVSH 488
Query: 583 HPPISACHAE--SENFAFWQDMKWKNKFWGKSLEIVPVGTVNVSLPRFGDHFEWNKVTSC 640
HPPISA +AE ++ F + K+KF G S+ + +G VS + +H+
Sbjct: 489 HPPISAFYAECFNKKIQFNAHIWTKSKFLGMSIGVHNIGQGCVSCLDYDEHYILTFPNGY 548
Query: 641 IHNVLSGQRWIEHYGEVLIRNTQDSSCHCKITFCKAKYWSSNVHEVQGAVLS-RSGRVLH 699
++L+ W+E GE I N + I F ++ H + + S +
Sbjct: 549 GRSILT-VPWVELGGECNI-NCSKTGYSANIIFHTKPFYGGKKHRITAEIFSPNDKKSFC 606
Query: 700 RLFGKWHEGLYRGPTPGGQCIWKPNSMPPDHERNFGFTQFALELNELTAELKRSLPSTDT 759
+ G+W+ +Y G ++ P ++ +L + RSL T
Sbjct: 607 SIEGEWNGVMYAKYATGENTVFVDTKKLPIIKKK------VRKLEDQNEYESRSLWKDVT 660
Query: 760 RLRPDQRYLEEGNIQAAEAQKRRIEQLQRDRRKVMEENNIVHQARFF 806
L+ +I AA K R+E+ QR + +E I + R F
Sbjct: 661 ------FNLKIRDIDAATEAKHRLEERQRAEARERKEKEIQWETRLF 701
Score = 45.1 bits (105), Expect = 3e-04
Identities = 25/95 (26%), Positives = 47/95 (49%), Gaps = 5/95 (5%)
Query: 59 KWP--LKGWHKRYFVLE--DGILHYATTRQDITKGKLHGSIDVRLSVMSI-NKKAQRIDL 113
KW +KGW R+FVL+ G+L Y T++ + +G G + +R +V+ I ++ +
Sbjct: 11 KWTNVMKGWQYRWFVLDYNAGLLSYYTSKDKMMRGSRRGCVRLRGAVIGIDDEDDSTFTI 70
Query: 114 DTEDNIYHLKIKSQDLFQSWVAQLRAHRLAHRLDM 148
+ +H + + D + W+ L L H L +
Sbjct: 71 TVDQKTFHFQARDADEREKWIHALEETILRHTLQL 105
>gi|22547171 oxysterol binding protein-like 9 isoform c [Homo
sapiens]
Length = 626
Score = 85.9 bits (211), Expect = 1e-16
Identities = 87/347 (25%), Positives = 145/347 (41%), Gaps = 43/347 (12%)
Query: 487 IGKDLSKVSMPVQLNEPLNTLQRLCEELEYSSLLDQASRIADPCERMVYIAAFAVSAYSS 546
+G DL+KV +P + E + L+ + + L S DP +RMV + + +SA+ +
Sbjct: 274 LGMDLTKVVLPTFILERRSLLEMYADFFAHPDLFVSISDQKDPKDRMVQVVKWYLSAFHA 333
Query: 547 TYHRAGC---KPFNPVLGETYEC----------------ERP-----DRGFRFISEQVSH 582
R G KP+NP+LGE ++C E P F++EQVSH
Sbjct: 334 G--RKGSVAKKPYNPILGEIFQCHWTLPNDTEENTELVSEGPVPWVSKNSVTFVAEQVSH 391
Query: 583 HPPISACHAE--SENFAFWQDMKWKNKFWGKSLEIVPVGTVNVSLPRFGDHFEWNKVTSC 640
HPPISA +AE ++ F + K+KF G S+ + +G VS + +H+
Sbjct: 392 HPPISAFYAECFNKKIQFNAHIWTKSKFLGMSIGVHNIGQGCVSCLDYDEHYILTFPNGY 451
Query: 641 IHNVLSGQRWIEHYGEVLIRNTQDSSCHCKITFCKAKYWSSNVHEVQGAVLS-RSGRVLH 699
++L+ W+E GE I N + I F ++ H + + S +
Sbjct: 452 GRSILT-VPWVELGGECNI-NCSKTGYSANIIFHTKPFYGGKKHRITAEIFSPNDKKSFC 509
Query: 700 RLFGKWHEGLYRGPTPGGQCIWKPNSMPPDHERNFGFTQFALELNELTAELKRSLPSTDT 759
+ G+W+ +Y G ++ P ++ +L + RSL T
Sbjct: 510 SIEGEWNGVMYAKYATGENTVFVDTKKLPIIKKK------VRKLEDQNEYESRSLWKDVT 563
Query: 760 RLRPDQRYLEEGNIQAAEAQKRRIEQLQRDRRKVMEENNIVHQARFF 806
L+ +I AA K R+E+ QR + +E I + R F
Sbjct: 564 ------FNLKIRDIDAATEAKHRLEERQRAEARERKEKEIQWETRLF 604
>gi|22547169 oxysterol binding protein-like 9 isoform b [Homo
sapiens]
Length = 571
Score = 85.9 bits (211), Expect = 1e-16
Identities = 87/347 (25%), Positives = 145/347 (41%), Gaps = 43/347 (12%)
Query: 487 IGKDLSKVSMPVQLNEPLNTLQRLCEELEYSSLLDQASRIADPCERMVYIAAFAVSAYSS 546
+G DL+KV +P + E + L+ + + L S DP +RMV + + +SA+ +
Sbjct: 219 LGMDLTKVVLPTFILERRSLLEMYADFFAHPDLFVSISDQKDPKDRMVQVVKWYLSAFHA 278
Query: 547 TYHRAGC---KPFNPVLGETYEC----------------ERP-----DRGFRFISEQVSH 582
R G KP+NP+LGE ++C E P F++EQVSH
Sbjct: 279 G--RKGSVAKKPYNPILGEIFQCHWTLPNDTEENTELVSEGPVPWVSKNSVTFVAEQVSH 336
Query: 583 HPPISACHAE--SENFAFWQDMKWKNKFWGKSLEIVPVGTVNVSLPRFGDHFEWNKVTSC 640
HPPISA +AE ++ F + K+KF G S+ + +G VS + +H+
Sbjct: 337 HPPISAFYAECFNKKIQFNAHIWTKSKFLGMSIGVHNIGQGCVSCLDYDEHYILTFPNGY 396
Query: 641 IHNVLSGQRWIEHYGEVLIRNTQDSSCHCKITFCKAKYWSSNVHEVQGAVLS-RSGRVLH 699
++L+ W+E GE I N + I F ++ H + + S +
Sbjct: 397 GRSILT-VPWVELGGECNI-NCSKTGYSANIIFHTKPFYGGKKHRITAEIFSPNDKKSFC 454
Query: 700 RLFGKWHEGLYRGPTPGGQCIWKPNSMPPDHERNFGFTQFALELNELTAELKRSLPSTDT 759
+ G+W+ +Y G ++ P ++ +L + RSL T
Sbjct: 455 SIEGEWNGVMYAKYATGENTVFVDTKKLPIIKKK------VRKLEDQNEYESRSLWKDVT 508
Query: 760 RLRPDQRYLEEGNIQAAEAQKRRIEQLQRDRRKVMEENNIVHQARFF 806
L+ +I AA K R+E+ QR + +E I + R F
Sbjct: 509 ------FNLKIRDIDAATEAKHRLEERQRAEARERKEKEIQWETRLF 549
>gi|22547167 oxysterol binding protein-like 9 isoform a [Homo
sapiens]
Length = 558
Score = 85.9 bits (211), Expect = 1e-16
Identities = 87/347 (25%), Positives = 145/347 (41%), Gaps = 43/347 (12%)
Query: 487 IGKDLSKVSMPVQLNEPLNTLQRLCEELEYSSLLDQASRIADPCERMVYIAAFAVSAYSS 546
+G DL+KV +P + E + L+ + + L S DP +RMV + + +SA+ +
Sbjct: 206 LGMDLTKVVLPTFILERRSLLEMYADFFAHPDLFVSISDQKDPKDRMVQVVKWYLSAFHA 265
Query: 547 TYHRAGC---KPFNPVLGETYEC----------------ERP-----DRGFRFISEQVSH 582
R G KP+NP+LGE ++C E P F++EQVSH
Sbjct: 266 G--RKGSVAKKPYNPILGEIFQCHWTLPNDTEENTELVSEGPVPWVSKNSVTFVAEQVSH 323
Query: 583 HPPISACHAE--SENFAFWQDMKWKNKFWGKSLEIVPVGTVNVSLPRFGDHFEWNKVTSC 640
HPPISA +AE ++ F + K+KF G S+ + +G VS + +H+
Sbjct: 324 HPPISAFYAECFNKKIQFNAHIWTKSKFLGMSIGVHNIGQGCVSCLDYDEHYILTFPNGY 383
Query: 641 IHNVLSGQRWIEHYGEVLIRNTQDSSCHCKITFCKAKYWSSNVHEVQGAVLS-RSGRVLH 699
++L+ W+E GE I N + I F ++ H + + S +
Sbjct: 384 GRSILT-VPWVELGGECNI-NCSKTGYSANIIFHTKPFYGGKKHRITAEIFSPNDKKSFC 441
Query: 700 RLFGKWHEGLYRGPTPGGQCIWKPNSMPPDHERNFGFTQFALELNELTAELKRSLPSTDT 759
+ G+W+ +Y G ++ P ++ +L + RSL T
Sbjct: 442 SIEGEWNGVMYAKYATGENTVFVDTKKLPIIKKK------VRKLEDQNEYESRSLWKDVT 495
Query: 760 RLRPDQRYLEEGNIQAAEAQKRRIEQLQRDRRKVMEENNIVHQARFF 806
L+ +I AA K R+E+ QR + +E I + R F
Sbjct: 496 ------FNLKIRDIDAATEAKHRLEERQRAEARERKEKEIQWETRLF 536
>gi|22547165 oxysterol binding protein-like 9 isoform a [Homo
sapiens]
Length = 558
Score = 85.9 bits (211), Expect = 1e-16
Identities = 87/347 (25%), Positives = 145/347 (41%), Gaps = 43/347 (12%)
Query: 487 IGKDLSKVSMPVQLNEPLNTLQRLCEELEYSSLLDQASRIADPCERMVYIAAFAVSAYSS 546
+G DL+KV +P + E + L+ + + L S DP +RMV + + +SA+ +
Sbjct: 206 LGMDLTKVVLPTFILERRSLLEMYADFFAHPDLFVSISDQKDPKDRMVQVVKWYLSAFHA 265
Query: 547 TYHRAGC---KPFNPVLGETYEC----------------ERP-----DRGFRFISEQVSH 582
R G KP+NP+LGE ++C E P F++EQVSH
Sbjct: 266 G--RKGSVAKKPYNPILGEIFQCHWTLPNDTEENTELVSEGPVPWVSKNSVTFVAEQVSH 323
Query: 583 HPPISACHAE--SENFAFWQDMKWKNKFWGKSLEIVPVGTVNVSLPRFGDHFEWNKVTSC 640
HPPISA +AE ++ F + K+KF G S+ + +G VS + +H+
Sbjct: 324 HPPISAFYAECFNKKIQFNAHIWTKSKFLGMSIGVHNIGQGCVSCLDYDEHYILTFPNGY 383
Query: 641 IHNVLSGQRWIEHYGEVLIRNTQDSSCHCKITFCKAKYWSSNVHEVQGAVLS-RSGRVLH 699
++L+ W+E GE I N + I F ++ H + + S +
Sbjct: 384 GRSILT-VPWVELGGECNI-NCSKTGYSANIIFHTKPFYGGKKHRITAEIFSPNDKKSFC 441
Query: 700 RLFGKWHEGLYRGPTPGGQCIWKPNSMPPDHERNFGFTQFALELNELTAELKRSLPSTDT 759
+ G+W+ +Y G ++ P ++ +L + RSL T
Sbjct: 442 SIEGEWNGVMYAKYATGENTVFVDTKKLPIIKKK------VRKLEDQNEYESRSLWKDVT 495
Query: 760 RLRPDQRYLEEGNIQAAEAQKRRIEQLQRDRRKVMEENNIVHQARFF 806
L+ +I AA K R+E+ QR + +E I + R F
Sbjct: 496 ------FNLKIRDIDAATEAKHRLEERQRAEARERKEKEIQWETRLF 536
>gi|19923592 oxysterol binding protein-like 11 [Homo sapiens]
Length = 747
Score = 82.0 bits (201), Expect = 2e-15
Identities = 86/388 (22%), Positives = 155/388 (39%), Gaps = 74/388 (19%)
Query: 487 IGKDLSKVSMPVQLNEPLNTLQRLCEELEYSSLLDQASRIADPCERMV-YIAAFAVSAYS 545
+G DL++V +P + E + L+ + + + L + A +RM+ ++ + S +
Sbjct: 379 LGMDLTRVVLPTFILEKRSLLEMYADFMSHPDLFIAITNGATAEDRMIRFVEYYLTSFHE 438
Query: 546 STYHRAGCKPFNPVLGETYECE------------------------RPDRG--------- 572
KP+NP++GET+ C P G
Sbjct: 439 GRKGAIAKKPYNPIIGETFHCSWKMPKSEVASSVFSSSSTQGVTNHAPLSGESLTQVGSD 498
Query: 573 ---FRFISEQVSHHPPISACHAE-SENFAFWQDMKW-KNKFWGKSLEIVPVGTVNVSLPR 627
RF++EQVSHHPP+S +AE +E W K+KF G S+ + VG +SL
Sbjct: 499 CYTVRFVAEQVSHHPPVSGFYAECTERKMCVNAHVWTKSKFLGMSIGVTMVGEGILSLLE 558
Query: 628 FGDHFEWNKVTSCIHNVLSGQRWIEHYGEVLIRNTQDSSCHCKITFCKAKYWSSNVHEVQ 687
G+ + ++ + ++L+ W+E G+V + N + ITF ++ +H V
Sbjct: 559 HGEEYTFSLPCAYARSILT-VPWVELGGKVSV-NCAKTGYSASITFHTKPFYGGKLHRVT 616
Query: 688 GAVLSR-SGRVLHRLFGKWHEGLYRGPTPGGQCIWKPNSMPPDHERNFGFTQFALELNEL 746
V + V+ R+ G+W+ L + + G T++ ++L +L
Sbjct: 617 AEVKHNITNTVVCRVQGEWNSVL-------------------EFTYSNGETKY-VDLTKL 656
Query: 747 TAELKRSLPSTDTRLRPDQRY-------LEEGNIQAAEAQKRRIEQLQRDRRKVMEENNI 799
KR P +R L E I A K +E+ QR + E
Sbjct: 657 AVTKKRVRPLEKQDPFESRRLWKNVTDSLRESEIDKATEHKHTLEERQRTEERHRTETGT 716
Query: 800 VHQARFFRRQTDSSGKEWWVTNNTYWRL 827
+ ++F ++ D WV + W++
Sbjct: 717 PWKTKYFIKEGDG-----WVYHKPLWKI 739
>gi|217416392 pleckstrin homology domain containing, family H (with
MyTH4 domain) member 2 [Homo sapiens]
Length = 1493
Score = 47.4 bits (111), Expect = 6e-05
Identities = 28/93 (30%), Positives = 50/93 (53%), Gaps = 3/93 (3%)
Query: 47 PERQEGHLLKKRKWPLKGWHKRYFVLEDG-ILHYATTRQDITKGKLHGSIDVRLSVMSIN 105
P + G+LLK +K W +R+FVL+ G +L+Y + I K + H + S++ +
Sbjct: 703 PLEKSGYLLKM-SGKVKSWKRRWFVLKGGELLYYKSPSDVIRKPQGHIELSASCSILRGD 761
Query: 106 KKAQRIDLDTEDNIYHLKIKSQDLFQSWVAQLR 138
K Q + L TE + Y+L S ++ + W+ L+
Sbjct: 762 NK-QTVQLTTEKHTYYLTADSPNILEEWIKVLQ 793
>gi|55741447 pleckstrin homology domain containing, family H (with
MyTH4 domain) member 1 [Homo sapiens]
Length = 1364
Score = 41.6 bits (96), Expect = 0.003
Identities = 29/101 (28%), Positives = 49/101 (48%), Gaps = 4/101 (3%)
Query: 40 LGTEGVMPERQEGHLLKKRKWPLKGWHKRYFVLEDGILHYATTRQDITKGKLHGSIDVRL 99
LG G E+ G+LLK +K W +R+FVL G + Y + D+ + K G +D+
Sbjct: 572 LGLGGESLEKS-GYLLKMGS-QVKTWKRRWFVLRQGQIMYYKSPSDVIR-KPQGQVDLNS 628
Query: 100 SVMSI-NKKAQRIDLDTEDNIYHLKIKSQDLFQSWVAQLRA 139
+ + +Q L +E Y+L S L + W+ L++
Sbjct: 629 RCQIVRGEGSQTFQLISEKKTYYLTADSPSLLEEWIRVLQS 669
>gi|14165452 alpha 3 type IV collagen binding protein isoform 2
[Homo sapiens]
Length = 598
Score = 40.8 bits (94), Expect = 0.005
Identities = 26/102 (25%), Positives = 53/102 (51%), Gaps = 8/102 (7%)
Query: 47 PERQEGHLLKK----RKWP--LKGWHKRYFVLEDGILHYATTRQDITKGKLHGSIDVRLS 100
PE + G +++ KW + GW R+ VL++ L Y + +D T+ GSI + +
Sbjct: 16 PETESGPPVERCGVLSKWTNYIHGWQDRWVVLKNNALSYYKS-EDETEYGCRGSICLSKA 74
Query: 101 VMSINKKAQ-RIDLDTEDNIYHLKIKSQDLFQSWVAQLRAHR 141
V++ + + R D+ D++++L+ + D Q W+ + H+
Sbjct: 75 VITPHDFDECRFDISVNDSVWYLRAQDPDHRQQWIDAIEQHK 116
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.131 0.402
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 35,110,760
Number of Sequences: 37866
Number of extensions: 1662286
Number of successful extensions: 6877
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 36
Number of HSP's successfully gapped in prelim test: 95
Number of HSP's that attempted gapping in prelim test: 6589
Number of HSP's gapped (non-prelim): 265
length of query: 842
length of database: 18,247,518
effective HSP length: 111
effective length of query: 731
effective length of database: 14,044,392
effective search space: 10266450552
effective search space used: 10266450552
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.